id	sid	tid	token	lemma	pos
dti-1351	1	1	1drug	1drug	NUM
dti-1351	1	2	target	target	NOUN
dti-1351	1	3	insights	insight	VERB
dti-1351	1	4	2014:8	2014:8	NUM
dti-1351	1	5	open	open	ADJ
dti-1351	1	6	access	access	NOUN
dti-1351	1	7	:	:	PUNCT
dti-1351	1	8	full	full	ADJ
dti-1351	1	9	open	open	ADJ
dti-1351	1	10	access	access	NOUN
dti-1351	1	11	to	to	ADP
dti-1351	1	12	this	this	PRON
dti-1351	1	13	and	and	CCONJ
dti-1351	1	14	thousands	thousand	NOUN
dti-1351	1	15	of	of	ADP
dti-1351	1	16	other	other	ADJ
dti-1351	1	17	papers	paper	NOUN
dti-1351	1	18	at	at	ADP
dti-1351	1	19	http://www.la-press.com	http://www.la-press.com	X
dti-1351	1	20	.	.	PUNCT
dti-1351	2	1	drug	drug	NOUN
dti-1351	2	2	target	target	NOUN
dti-1351	2	3	insights	insight	NOUN
dti-1351	2	4	introduction	introduction	NOUN
dti-1351	2	5	plague	plague	NOUN
dti-1351	2	6	,	,	PUNCT
dti-1351	2	7	a	a	DET
dti-1351	2	8	disease	disease	NOUN
dti-1351	2	9	that	that	PRON
dti-1351	2	10	can	can	AUX
dti-1351	2	11	affect	affect	VERB
dti-1351	2	12	humans	human	NOUN
dti-1351	2	13	as	as	ADV
dti-1351	2	14	well	well	ADV
dti-1351	2	15	as	as	ADP
dti-1351	2	16	other	other	ADJ
dti-1351	2	17	mammals	mammal	NOUN
dti-1351	2	18	,	,	PUNCT
dti-1351	2	19	is	be	AUX
dti-1351	2	20	caused	cause	VERB
dti-1351	2	21	by	by	ADP
dti-1351	2	22	yersinia	yersinia	NOUN
dti-1351	2	23	pestis	pestis	PROPN
dti-1351	2	24	and	and	CCONJ
dti-1351	2	25	classified	classify	VERB
dti-1351	2	26	as	as	ADP
dti-1351	2	27	a	a	DET
dti-1351	2	28	cate­	cate­	PROPN
dti-1351	2	29	gory	gory	NOUN
dti-1351	2	30	a	a	DET
dti-1351	2	31	agent	agent	NOUN
dti-1351	2	32	of	of	ADP
dti-1351	2	33	bioterrorism.1	bioterrorism.1	PROPN
dti-1351	2	34	in	in	ADP
dti-1351	2	35	large	large	ADJ
dti-1351	2	36	historic	historic	ADJ
dti-1351	2	37	pandemics	pandemic	NOUN
dti-1351	2	38	,	,	PUNCT
dti-1351	2	39	this	this	DET
dti-1351	2	40	infectious	infectious	ADJ
dti-1351	2	41	disease	disease	NOUN
dti-1351	2	42	caused	cause	VERB
dti-1351	2	43	the	the	DET
dti-1351	2	44	death	death	NOUN
dti-1351	2	45	of	of	ADP
dti-1351	2	46	millions	million	NOUN
dti-1351	2	47	of	of	ADP
dti-1351	2	48	people	people	NOUN
dti-1351	2	49	,	,	PUNCT
dti-1351	2	50	and	and	CCONJ
dti-1351	2	51	there	there	PRON
dti-1351	2	52	have	have	AUX
dti-1351	2	53	been	be	AUX
dti-1351	2	54	numerous	numerous	ADJ
dti-1351	2	55	other	other	ADJ
dti-1351	2	56	deadly	deadly	ADJ
dti-1351	2	57	but	but	CCONJ
dti-1351	2	58	localized	localized	ADJ
dti-1351	2	59	outbreaks.2	outbreaks.2	PROPN
dti-1351	2	60	usually	usually	ADV
dti-1351	2	61	,	,	PUNCT
dti-1351	2	62	plague	plague	NOUN
dti-1351	2	63	is	be	AUX
dti-1351	2	64	transmitted	transmit	VERB
dti-1351	2	65	subcutaneously	subcutaneously	ADV
dti-1351	2	66	to	to	ADP
dti-1351	2	67	humans	human	NOUN
dti-1351	2	68	by	by	ADP
dti-1351	2	69	the	the	DET
dti-1351	2	70	bite	bite	NOUN
dti-1351	2	71	of	of	ADP
dti-1351	2	72	an	an	DET
dti-1351	2	73	infected	infected	ADJ
dti-1351	2	74	flea	flea	NOUN
dti-1351	2	75	.	.	PUNCT
dti-1351	3	1	but	but	CCONJ
dti-1351	3	2	especially	especially	ADV
dti-1351	3	3	during	during	ADP
dti-1351	3	4	pandemics	pandemic	NOUN
dti-1351	3	5	of	of	ADP
dti-1351	3	6	the	the	DET
dti-1351	3	7	disease	disease	NOUN
dti-1351	3	8	,	,	PUNCT
dti-1351	3	9	it	it	PRON
dti-1351	3	10	can	can	AUX
dti-1351	3	11	also	also	ADV
dti-1351	3	12	be	be	AUX
dti-1351	3	13	transmitted	transmit	VERB
dti-1351	3	14	by	by	ADP
dti-1351	3	15	air	air	NOUN
dti-1351	3	16	.	.	PUNCT
dti-1351	4	1	the	the	DET
dti-1351	4	2	disease	disease	NOUN
dti-1351	4	3	has	have	AUX
dti-1351	4	4	recently	recently	ADV
dti-1351	4	5	been	be	AUX
dti-1351	4	6	recognized	recognize	VERB
dti-1351	4	7	as	as	ADP
dti-1351	4	8	a	a	DET
dti-1351	4	9	re­emerging	re­emerging	NOUN
dti-1351	4	10	disease	disease	NOUN
dti-1351	4	11	by	by	ADP
dti-1351	4	12	the	the	DET
dti-1351	4	13	world	world	PROPN
dti-1351	4	14	health	health	PROPN
dti-1351	4	15	organization.3	organization.3	PROPN
dti-1351	4	16	currently	currently	ADV
dti-1351	4	17	there	there	PRON
dti-1351	4	18	is	be	VERB
dti-1351	4	19	no	no	DET
dti-1351	4	20	available	available	ADJ
dti-1351	4	21	fda­licensed	fda­license	VERB
dti-1351	4	22	plague	plague	NOUN
dti-1351	4	23	vaccine	vaccine	NOUN
dti-1351	4	24	in	in	ADP
dti-1351	4	25	the	the	DET
dti-1351	4	26	usa	usa	PROPN
dti-1351	4	27	.	.	PROPN
dti-1351	4	28	subunit	subunit	NOUN
dti-1351	4	29	vaccine	vaccine	NOUN
dti-1351	4	30	processing	processing	NOUN
dti-1351	4	31	is	be	AUX
dti-1351	4	32	a	a	DET
dti-1351	4	33	current	current	ADJ
dti-1351	4	34	research	research	NOUN
dti-1351	4	35	focus	focus	NOUN
dti-1351	4	36	,	,	PUNCT
dti-1351	4	37	followed	follow	VERB
dti-1351	4	38	by	by	ADP
dti-1351	4	39	the	the	DET
dti-1351	4	40	search	search	NOUN
dti-1351	4	41	for	for	ADP
dti-1351	4	42	different	different	ADJ
dti-1351	4	43	hybrid	hybrid	ADJ
dti-1351	4	44	vaccines	vaccine	NOUN
dti-1351	4	45	.	.	PUNCT
dti-1351	5	1	upon	upon	SCONJ
dti-1351	5	2	immunization	immunization	NOUN
dti-1351	5	3	with	with	ADP
dti-1351	5	4	these	these	DET
dti-1351	5	5	vaccines	vaccine	NOUN
dti-1351	5	6	,	,	PUNCT
dti-1351	5	7	there	there	PRON
dti-1351	5	8	is	be	VERB
dti-1351	5	9	no	no	DET
dti-1351	5	10	significant	significant	ADJ
dti-1351	5	11	difference	difference	NOUN
dti-1351	5	12	obtained	obtain	VERB
dti-1351	5	13	for	for	ADP
dti-1351	5	14	host	host	NOUN
dti-1351	5	15	plague	plague	NOUN
dti-1351	5	16	protection.4	protection.4	VERB
dti-1351	5	17	in	in	ADP
dti-1351	5	18	another	another	DET
dti-1351	5	19	report	report	NOUN
dti-1351	5	20	it	it	PRON
dti-1351	5	21	has	have	AUX
dti-1351	5	22	been	be	AUX
dti-1351	5	23	found	find	VERB
dti-1351	5	24	that	that	SCONJ
dti-1351	5	25	effective	effective	ADJ
dti-1351	5	26	antibiotics	antibiotic	NOUN
dti-1351	5	27	have	have	VERB
dti-1351	5	28	to	to	PART
dti-1351	5	29	be	be	AUX
dti-1351	5	30	given	give	VERB
dti-1351	5	31	within	within	ADP
dti-1351	5	32	24	24	NUM
dti-1351	5	33	hours	hour	NOUN
dti-1351	5	34	after	after	ADP
dti-1351	5	35	exposure	exposure	NOUN
dti-1351	5	36	to	to	ADP
dti-1351	5	37	the	the	DET
dti-1351	5	38	aerosolized	aerosolize	VERB
dti-1351	5	39	form	form	NOUN
dti-1351	5	40	of	of	ADP
dti-1351	5	41	pathogen.5	pathogen.5	PROPN
dti-1351	5	42	there	there	PRON
dti-1351	5	43	are	be	VERB
dti-1351	5	44	three	three	NUM
dti-1351	5	45	types	type	NOUN
dti-1351	5	46	of	of	ADP
dti-1351	5	47	plague	plague	NOUN
dti-1351	5	48	:	:	PUNCT
dti-1351	5	49	pneumonic	pneumonic	ADJ
dti-1351	5	50	,	,	PUNCT
dti-1351	5	51	septicemic	septicemic	ADJ
dti-1351	5	52	and	and	CCONJ
dti-1351	5	53	bubonic	bubonic	NOUN
dti-1351	5	54	plagues	plague	NOUN
dti-1351	5	55	.	.	PUNCT
dti-1351	6	1	all	all	DET
dti-1351	6	2	these	these	DET
dti-1351	6	3	forms	form	NOUN
dti-1351	6	4	are	be	AUX
dti-1351	6	5	also	also	ADV
dti-1351	6	6	responsible	responsible	ADJ
dti-1351	6	7	for	for	ADP
dti-1351	6	8	numerous	numerous	ADJ
dti-1351	6	9	epidemics	epidemic	NOUN
dti-1351	6	10	in	in	ADP
dti-1351	6	11	human	human	ADJ
dti-1351	6	12	history	history	NOUN
dti-1351	6	13	,	,	PUNCT
dti-1351	6	14	as	as	ADV
dti-1351	6	15	well	well	ADV
dti-1351	6	16	as	as	ADP
dti-1351	6	17	three	three	NUM
dti-1351	6	18	catastrophic	catastrophic	ADJ
dti-1351	6	19	pandemics	pandemic	NOUN
dti-1351	6	20	.	.	PUNCT
dti-1351	7	1	first	first	ADV
dti-1351	7	2	,	,	PUNCT
dti-1351	7	3	justinian	justinian	PROPN
dti-1351	7	4	’s	’s	PART
dti-1351	7	5	plague	plague	NOUN
dti-1351	7	6	(	(	PUNCT
dti-1351	7	7	6th–8th	6th–8th	ADJ
dti-1351	7	8	centuries	century	NOUN
dti-1351	7	9	)	)	PUNCT
dti-1351	7	10	spread	spread	VERB
dti-1351	7	11	from	from	ADP
dti-1351	7	12	egypt	egypt	PROPN
dti-1351	7	13	to	to	ADP
dti-1351	7	14	areas	area	NOUN
dti-1351	7	15	surrounding	surround	VERB
dti-1351	7	16	the	the	DET
dti-1351	7	17	mediterranean.6	mediterranean.6	PROPN
dti-1351	7	18	second	second	NOUN
dti-1351	7	19	,	,	PUNCT
dti-1351	7	20	the	the	DET
dti-1351	7	21	“	"	PUNCT
dti-1351	7	22	black	black	ADJ
dti-1351	7	23	death	death	NOUN
dti-1351	7	24	”	"	PUNCT
dti-1351	7	25	spread	spread	VERB
dti-1351	7	26	from	from	ADP
dti-1351	7	27	the	the	DET
dti-1351	7	28	caspian	caspian	PROPN
dti-1351	7	29	sea	sea	NOUN
dti-1351	7	30	to	to	ADP
dti-1351	7	31	almost	almost	ADV
dti-1351	7	32	all	all	PRON
dti-1351	7	33	european	european	ADJ
dti-1351	7	34	countries	country	NOUN
dti-1351	7	35	,	,	PUNCT
dti-1351	7	36	causing	cause	VERB
dti-1351	7	37	the	the	DET
dti-1351	7	38	demise	demise	NOUN
dti-1351	7	39	of	of	ADP
dti-1351	7	40	one	one	NUM
dti-1351	7	41	third	third	NOUN
dti-1351	7	42	of	of	ADP
dti-1351	7	43	the	the	DET
dti-1351	7	44	european	european	ADJ
dti-1351	7	45	population	population	NOUN
dti-1351	7	46	over	over	ADP
dti-1351	7	47	the	the	DET
dti-1351	7	48	period	period	NOUN
dti-1351	7	49	of	of	ADP
dti-1351	7	50	just	just	ADV
dti-1351	7	51	a	a	DET
dti-1351	7	52	few	few	ADJ
dti-1351	7	53	years	year	NOUN
dti-1351	7	54	in	in	ADP
dti-1351	7	55	the	the	DET
dti-1351	7	56	mid­14th	mid­14th	ADJ
dti-1351	7	57	century	century	NOUN
dti-1351	7	58	.	.	PUNCT
dti-1351	8	1	the	the	DET
dti-1351	8	2	third	third	ADJ
dti-1351	8	3	one	one	NOUN
dti-1351	8	4	is	be	AUX
dti-1351	8	5	a	a	DET
dti-1351	8	6	modern	modern	ADJ
dti-1351	8	7	plague	plague	NOUN
dti-1351	8	8	pandemic	pandemic	NOUN
dti-1351	8	9	,	,	PUNCT
dti-1351	8	10	which	which	PRON
dti-1351	8	11	began	begin	VERB
dti-1351	8	12	in	in	ADP
dti-1351	8	13	the	the	DET
dti-1351	8	14	yunnan	yunnan	NOUN
dti-1351	8	15	region	region	NOUN
dti-1351	8	16	of	of	ADP
dti-1351	8	17	china	china	PROPN
dti-1351	8	18	in	in	ADP
dti-1351	8	19	the	the	DET
dti-1351	8	20	mid­19th	mid­19th	ADJ
dti-1351	8	21	century	century	NOUN
dti-1351	8	22	,	,	PUNCT
dti-1351	8	23	in	in	ADP
dti-1351	8	24	silico	silico	NOUN
dti-1351	8	25	molecular	molecular	ADJ
dti-1351	8	26	characterization	characterization	NOUN
dti-1351	8	27	of	of	ADP
dti-1351	8	28	cysteine	cysteine	NOUN
dti-1351	8	29	protease	protease	NOUN
dti-1351	8	30	yopt	yopt	PROPN
dti-1351	8	31	from	from	ADP
dti-1351	8	32	yersinia	yersinia	PROPN
dti-1351	8	33	pestis	pestis	PROPN
dti-1351	8	34	by	by	ADP
dti-1351	8	35	homology	homology	NOUN
dti-1351	8	36	modeling	modeling	NOUN
dti-1351	8	37	and	and	CCONJ
dti-1351	8	38	binding	bind	VERB
dti-1351	8	39	site	site	NOUN
dti-1351	8	40	identification	identification	NOUN
dti-1351	8	41	md	md	PROPN
dti-1351	8	42	.	.	PROPN
dti-1351	9	1	anayet	anayet	PROPN
dti-1351	9	2	hasan	hasan	PROPN
dti-1351	9	3	,	,	PUNCT
dti-1351	9	4	s.	s.	PROPN
dti-1351	9	5	m.	m.	PROPN
dti-1351	9	6	alauddin	alauddin	PROPN
dti-1351	9	7	,	,	PUNCT
dti-1351	9	8	mohammad	mohammad	PROPN
dti-1351	9	9	al	al	PROPN
dti-1351	9	10	amin	amin	PROPN
dti-1351	9	11	,	,	PUNCT
dti-1351	9	12	suza	suza	PROPN
dti-1351	9	13	mohammad	mohammad	PROPN
dti-1351	9	14	nur	nur	PROPN
dti-1351	9	15	and	and	CCONJ
dti-1351	9	16	adnan	adnan	PROPN
dti-1351	9	17	mannan	mannan	PROPN
dti-1351	9	18	department	department	PROPN
dti-1351	9	19	of	of	ADP
dti-1351	9	20	genetic	genetic	ADJ
dti-1351	9	21	engineering	engineering	NOUN
dti-1351	9	22	and	and	CCONJ
dti-1351	9	23	biotechnology	biotechnology	NOUN
dti-1351	9	24	,	,	PUNCT
dti-1351	9	25	faculty	faculty	NOUN
dti-1351	9	26	of	of	ADP
dti-1351	9	27	biological	biological	ADJ
dti-1351	9	28	sciences	science	NOUN
dti-1351	9	29	,	,	PUNCT
dti-1351	9	30	university	university	PROPN
dti-1351	9	31	of	of	ADP
dti-1351	9	32	chittagong	chittagong	PROPN
dti-1351	9	33	,	,	PUNCT
dti-1351	9	34	chittagong-4331	chittagong-4331	ADJ
dti-1351	9	35	,	,	PUNCT
dti-1351	9	36	bangladesh	bangladesh	NOUN
dti-1351	9	37	.	.	PUNCT
dti-1351	10	1	abstract	abstract	ADJ
dti-1351	10	2	:	:	PUNCT
dti-1351	11	1	plague	plague	NOUN
dti-1351	11	2	is	be	AUX
dti-1351	11	3	a	a	DET
dti-1351	11	4	major	major	ADJ
dti-1351	11	5	health	health	NOUN
dti-1351	11	6	concern	concern	NOUN
dti-1351	11	7	and	and	CCONJ
dti-1351	11	8	yersinia	yersinia	PROPN
dti-1351	11	9	pestis	pestis	PROPN
dti-1351	11	10	plays	play	VERB
dti-1351	11	11	the	the	DET
dti-1351	11	12	central	central	ADJ
dti-1351	11	13	causal	causal	ADJ
dti-1351	11	14	role	role	NOUN
dti-1351	11	15	in	in	ADP
dti-1351	11	16	this	this	DET
dti-1351	11	17	disease	disease	NOUN
dti-1351	11	18	.	.	PUNCT
dti-1351	12	1	yersinia	yersinia	PROPN
dti-1351	12	2	pestis	pestis	PROPN
dti-1351	12	3	has	have	AUX
dti-1351	12	4	developed	develop	VERB
dti-1351	12	5	resistance	resistance	NOUN
dti-1351	12	6	against	against	ADP
dti-1351	12	7	the	the	DET
dti-1351	12	8	commonly	commonly	ADV
dti-1351	12	9	available	available	ADJ
dti-1351	12	10	drugs	drug	NOUN
dti-1351	12	11	.	.	PUNCT
dti-1351	13	1	so	so	ADV
dti-1351	13	2	,	,	PUNCT
dti-1351	13	3	it	it	PRON
dti-1351	13	4	is	be	AUX
dti-1351	13	5	now	now	ADV
dti-1351	13	6	a	a	DET
dti-1351	13	7	key	key	ADJ
dti-1351	13	8	concern	concern	NOUN
dti-1351	13	9	to	to	PART
dti-1351	13	10	find	find	VERB
dti-1351	13	11	a	a	DET
dti-1351	13	12	new	new	ADJ
dti-1351	13	13	drug	drug	NOUN
dti-1351	13	14	target	target	NOUN
dti-1351	13	15	.	.	PUNCT
dti-1351	14	1	cysteine	cysteine	NOUN
dti-1351	14	2	protease	protease	NOUN
dti-1351	14	3	yopt	yopt	NOUN
dti-1351	14	4	enzyme	enzyme	NOUN
dti-1351	14	5	is	be	AUX
dti-1351	14	6	an	an	DET
dti-1351	14	7	important	important	ADJ
dti-1351	14	8	factor	factor	NOUN
dti-1351	14	9	used	use	VERB
dti-1351	14	10	by	by	ADP
dti-1351	14	11	yersinia	yersinia	PROPN
dti-1351	14	12	pestis	pestis	PROPN
dti-1351	14	13	for	for	ADP
dti-1351	14	14	pathogenesis	pathogenesis	NOUN
dti-1351	14	15	in	in	ADP
dti-1351	14	16	its	its	PRON
dti-1351	14	17	host	host	NOUN
dti-1351	14	18	and	and	CCONJ
dti-1351	14	19	it	it	PRON
dti-1351	14	20	has	have	VERB
dti-1351	14	21	the	the	DET
dti-1351	14	22	anti­phagocytic	anti­phagocytic	ADJ
dti-1351	14	23	function	function	NOUN
dti-1351	14	24	of	of	ADP
dti-1351	14	25	removal	removal	NOUN
dti-1351	14	26	of	of	ADP
dti-1351	14	27	c­termini	c­termini	ADJ
dti-1351	14	28	lipid	lipid	NOUN
dti-1351	14	29	modification	modification	NOUN
dti-1351	14	30	.	.	PUNCT
dti-1351	15	1	the	the	DET
dti-1351	15	2	3d	3d	PROPN
dti-1351	15	3	structure	structure	NOUN
dti-1351	15	4	of	of	ADP
dti-1351	15	5	cysteine	cysteine	NOUN
dti-1351	15	6	protease	protease	NOUN
dti-1351	15	7	yopt	yopt	NOUN
dti-1351	15	8	of	of	ADP
dti-1351	15	9	yersinia	yersinia	PROPN
dti-1351	15	10	pestis	pestis	PROPN
dti-1351	15	11	was	be	AUX
dti-1351	15	12	determined	determine	VERB
dti-1351	15	13	by	by	ADP
dti-1351	15	14	means	mean	NOUN
dti-1351	15	15	of	of	ADP
dti-1351	15	16	homology	homology	NOUN
dti-1351	15	17	modeling	modeling	NOUN
dti-1351	15	18	through	through	ADP
dti-1351	15	19	multiple	multiple	ADJ
dti-1351	15	20	alignments	alignment	NOUN
dti-1351	15	21	followed	follow	VERB
dti-1351	15	22	by	by	ADP
dti-1351	15	23	intensive	intensive	ADJ
dti-1351	15	24	optimization	optimization	NOUN
dti-1351	15	25	and	and	CCONJ
dti-1351	15	26	validation	validation	NOUN
dti-1351	15	27	.	.	PUNCT
dti-1351	16	1	the	the	DET
dti-1351	16	2	modeling	modeling	NOUN
dti-1351	16	3	was	be	AUX
dti-1351	16	4	done	do	VERB
dti-1351	16	5	by	by	ADP
dti-1351	16	6	phyre	phyre	PROPN
dti-1351	16	7	2	2	NUM
dti-1351	16	8	and	and	CCONJ
dti-1351	16	9	refined	refine	VERB
dti-1351	16	10	by	by	ADP
dti-1351	16	11	modrefiner	modrefiner	PROPN
dti-1351	16	12	.	.	PUNCT
dti-1351	17	1	the	the	DET
dti-1351	17	2	obtained	obtain	VERB
dti-1351	17	3	model	model	NOUN
dti-1351	17	4	was	be	AUX
dti-1351	17	5	verified	verify	VERB
dti-1351	17	6	with	with	ADP
dti-1351	17	7	structure	structure	NOUN
dti-1351	17	8	validation	validation	NOUN
dti-1351	17	9	programs	program	NOUN
dti-1351	17	10	such	such	ADJ
dti-1351	17	11	as	as	ADP
dti-1351	17	12	procheck	procheck	NOUN
dti-1351	17	13	,	,	PUNCT
dti-1351	17	14	verify	verify	VERB
dti-1351	17	15	3d	3d	NOUN
dti-1351	17	16	and	and	CCONJ
dti-1351	17	17	errat	errat	NOUN
dti-1351	17	18	for	for	ADP
dti-1351	17	19	reliability	reliability	NOUN
dti-1351	17	20	.	.	PUNCT
dti-1351	18	1	interacting	interact	VERB
dti-1351	18	2	partners	partner	NOUN
dti-1351	18	3	and	and	CCONJ
dti-1351	18	4	active	active	ADJ
dti-1351	18	5	sites	site	NOUN
dti-1351	18	6	were	be	AUX
dti-1351	18	7	also	also	ADV
dti-1351	18	8	determined	determine	VERB
dti-1351	18	9	.	.	PUNCT
dti-1351	19	1	procheck	procheck	NOUN
dti-1351	19	2	analysis	analysis	NOUN
dti-1351	19	3	showed	show	VERB
dti-1351	19	4	that	that	SCONJ
dti-1351	19	5	93	93	NUM
dti-1351	19	6	%	%	NOUN
dti-1351	19	7	of	of	ADP
dti-1351	19	8	the	the	DET
dti-1351	19	9	residues	residue	NOUN
dti-1351	19	10	are	be	AUX
dti-1351	19	11	in	in	ADP
dti-1351	19	12	the	the	DET
dti-1351	19	13	most	most	ADV
dti-1351	19	14	favored	favor	VERB
dti-1351	19	15	region	region	NOUN
dti-1351	19	16	,	,	PUNCT
dti-1351	19	17	5.9	5.9	NUM
dti-1351	19	18	%	%	NOUN
dti-1351	19	19	are	be	AUX
dti-1351	19	20	in	in	ADP
dti-1351	19	21	the	the	DET
dti-1351	19	22	additional	additional	ADJ
dti-1351	19	23	allowed	allow	VERB
dti-1351	19	24	region	region	NOUN
dti-1351	19	25	and	and	CCONJ
dti-1351	19	26	1.1	1.1	NUM
dti-1351	19	27	%	%	NOUN
dti-1351	19	28	are	be	AUX
dti-1351	19	29	in	in	ADP
dti-1351	19	30	the	the	DET
dti-1351	19	31	generously	generously	ADV
dti-1351	19	32	allowed	allow	VERB
dti-1351	19	33	region	region	NOUN
dti-1351	19	34	of	of	ADP
dti-1351	19	35	the	the	DET
dti-1351	19	36	ramachandran	ramachandran	PROPN
dti-1351	19	37	plot	plot	NOUN
dti-1351	19	38	.	.	PUNCT
dti-1351	20	1	the	the	DET
dti-1351	20	2	verify	verify	NOUN
dti-1351	20	3	3d	3d	NUM
dti-1351	20	4	value	value	NOUN
dti-1351	20	5	of	of	ADP
dti-1351	20	6	0.78	0.78	NUM
dti-1351	20	7	indicates	indicate	VERB
dti-1351	20	8	that	that	SCONJ
dti-1351	20	9	the	the	DET
dti-1351	20	10	environmental	environmental	ADJ
dti-1351	20	11	profile	profile	NOUN
dti-1351	20	12	of	of	ADP
dti-1351	20	13	the	the	DET
dti-1351	20	14	model	model	NOUN
dti-1351	20	15	is	be	AUX
dti-1351	20	16	good	good	ADJ
dti-1351	20	17	.	.	PUNCT
dti-1351	21	1	sopma	sopma	PROPN
dti-1351	21	2	is	be	AUX
dti-1351	21	3	employed	employ	VERB
dti-1351	21	4	for	for	ADP
dti-1351	21	5	calculation	calculation	NOUN
dti-1351	21	6	of	of	ADP
dti-1351	21	7	the	the	DET
dti-1351	21	8	secondary	secondary	ADJ
dti-1351	21	9	structural	structural	ADJ
dti-1351	21	10	features	feature	NOUN
dti-1351	21	11	of	of	ADP
dti-1351	21	12	cysteine	cysteine	NOUN
dti-1351	21	13	protease	protease	NOUN
dti-1351	21	14	yopt	yopt	NOUN
dti-1351	21	15	.	.	PUNCT
dti-1351	22	1	active	active	ADJ
dti-1351	22	2	site	site	NOUN
dti-1351	22	3	determination	determination	NOUN
dti-1351	22	4	through	through	ADP
dti-1351	22	5	castp	castp	ADJ
dti-1351	22	6	proposes	propose	VERB
dti-1351	22	7	that	that	SCONJ
dti-1351	22	8	this	this	DET
dti-1351	22	9	protein	protein	NOUN
dti-1351	22	10	can	can	AUX
dti-1351	22	11	be	be	AUX
dti-1351	22	12	utilized	utilize	VERB
dti-1351	22	13	as	as	ADP
dti-1351	22	14	a	a	DET
dti-1351	22	15	potential	potential	ADJ
dti-1351	22	16	drug	drug	NOUN
dti-1351	22	17	target	target	NOUN
dti-1351	22	18	.	.	PUNCT
dti-1351	23	1	however	however	ADV
dti-1351	23	2	,	,	PUNCT
dti-1351	23	3	these	these	DET
dti-1351	23	4	findings	finding	NOUN
dti-1351	23	5	should	should	AUX
dti-1351	23	6	further	far	ADV
dti-1351	23	7	be	be	AUX
dti-1351	23	8	confirmed	confirm	VERB
dti-1351	23	9	by	by	ADP
dti-1351	23	10	wet	wet	ADJ
dti-1351	23	11	lab	lab	NOUN
dti-1351	23	12	studies	study	NOUN
dti-1351	23	13	for	for	ADP
dti-1351	23	14	a	a	DET
dti-1351	23	15	targeted	target	VERB
dti-1351	23	16	therapeutic	therapeutic	ADJ
dti-1351	23	17	agent	agent	NOUN
dti-1351	23	18	design	design	NOUN
dti-1351	23	19	against	against	ADP
dti-1351	23	20	yersinia	yersinia	NOUN
dti-1351	23	21	pestis	pestis	PROPN
dti-1351	23	22	.	.	PUNCT
dti-1351	24	1	keywords	keyword	NOUN
dti-1351	24	2	:	:	PUNCT
dti-1351	25	1	plague	plague	NOUN
dti-1351	25	2	,	,	PUNCT
dti-1351	25	3	yersinia	yersinia	PROPN
dti-1351	25	4	pestis	pestis	PROPN
dti-1351	25	5	,	,	PUNCT
dti-1351	25	6	homology	homology	NOUN
dti-1351	25	7	modeling	modeling	NOUN
dti-1351	25	8	,	,	PUNCT
dti-1351	25	9	active	active	ADJ
dti-1351	25	10	site	site	NOUN
dti-1351	25	11	,	,	PUNCT
dti-1351	25	12	potential	potential	ADJ
dti-1351	25	13	drug	drug	NOUN
dti-1351	25	14	citation	citation	NOUN
dti-1351	25	15	:	:	PUNCT
dti-1351	25	16	hasan	hasan	PROPN
dti-1351	25	17	et	et	PROPN
dti-1351	25	18	al	al	PROPN
dti-1351	25	19	.	.	PROPN
dti-1351	26	1	in	in	ADP
dti-1351	26	2	silico	silico	NOUN
dti-1351	26	3	molecular	molecular	ADJ
dti-1351	26	4	characterization	characterization	NOUN
dti-1351	26	5	of	of	ADP
dti-1351	26	6	cysteine	cysteine	NOUN
dti-1351	26	7	protease	protease	NOUN
dti-1351	26	8	yopt	yopt	PROPN
dti-1351	26	9	from	from	ADP
dti-1351	26	10	yersinia	yersinia	PROPN
dti-1351	26	11	pestis	pestis	PROPN
dti-1351	26	12	by	by	ADP
dti-1351	26	13	homology	homology	NOUN
dti-1351	26	14	modeling	modeling	NOUN
dti-1351	26	15	and	and	CCONJ
dti-1351	26	16	binding	bind	VERB
dti-1351	26	17	site	site	NOUN
dti-1351	26	18	identification	identification	NOUN
dti-1351	26	19	.	.	PUNCT
dti-1351	27	1	drug	drug	NOUN
dti-1351	27	2	target	target	NOUN
dti-1351	27	3	insights	insight	VERB
dti-1351	27	4	2014:8	2014:8	NUM
dti-1351	27	5	1–9	1–9	NUM
dti-1351	27	6	doi	doi	NOUN
dti-1351	27	7	:	:	PUNCT
dti-1351	27	8	10.4137	10.4137	NUM
dti-1351	27	9	/	/	SYM
dti-1351	27	10	dti.s13529	dti.s13529	NOUN
dti-1351	27	11	.	.	PUNCT
dti-1351	28	1	received	receive	VERB
dti-1351	28	2	:	:	PUNCT
dti-1351	28	3	october	october	PROPN
dti-1351	28	4	30	30	NUM
dti-1351	28	5	,	,	PUNCT
dti-1351	28	6	2013	2013	NUM
dti-1351	28	7	.	.	PUNCT
dti-1351	29	1	resubmitted	resubmitte	VERB
dti-1351	29	2	:	:	PUNCT
dti-1351	29	3	december	december	PROPN
dti-1351	29	4	18	18	NUM
dti-1351	29	5	,	,	PUNCT
dti-1351	29	6	2013	2013	NUM
dti-1351	29	7	.	.	PUNCT
dti-1351	30	1	accepted	accept	VERB
dti-1351	30	2	for	for	ADP
dti-1351	30	3	publication	publication	NOUN
dti-1351	30	4	:	:	PUNCT
dti-1351	30	5	december	december	PROPN
dti-1351	30	6	19	19	NUM
dti-1351	30	7	,	,	PUNCT
dti-1351	30	8	2013	2013	NUM
dti-1351	30	9	.	.	PUNCT
dti-1351	31	1	academic	academic	ADJ
dti-1351	31	2	editor	editor	NOUN
dti-1351	31	3	:	:	PUNCT
dti-1351	31	4	prithviraj	prithviraj	PROPN
dti-1351	31	5	bose	bose	PROPN
dti-1351	31	6	,	,	PUNCT
dti-1351	31	7	editor	editor	NOUN
dti-1351	31	8	in	in	ADP
dti-1351	31	9	chief	chief	ADJ
dti-1351	31	10	type	type	NOUN
dti-1351	31	11	:	:	PUNCT
dti-1351	31	12	original	original	ADJ
dti-1351	31	13	research	research	NOUN
dti-1351	31	14	funding	funding	NOUN
dti-1351	31	15	:	:	PUNCT
dti-1351	32	1	author(s	author(s	NOUN
dti-1351	32	2	)	)	PUNCT
dti-1351	32	3	disclose	disclose	VERB
dti-1351	32	4	no	no	DET
dti-1351	32	5	funding	funding	NOUN
dti-1351	32	6	sources	source	NOUN
dti-1351	32	7	.	.	PUNCT
dti-1351	33	1	competing	compete	VERB
dti-1351	33	2	interests	interest	NOUN
dti-1351	33	3	:	:	PUNCT
dti-1351	33	4	author(s	author(s	NOUN
dti-1351	33	5	)	)	PUNCT
dti-1351	33	6	disclose	disclose	VERB
dti-1351	33	7	no	no	DET
dti-1351	33	8	potential	potential	ADJ
dti-1351	33	9	conflicts	conflict	NOUN
dti-1351	33	10	of	of	ADP
dti-1351	33	11	interest	interest	NOUN
dti-1351	33	12	.	.	PUNCT
dti-1351	34	1	copyright	copyright	NOUN
dti-1351	34	2	:	:	PUNCT
dti-1351	34	3	©	©	PROPN
dti-1351	34	4	the	the	DET
dti-1351	34	5	authors	author	NOUN
dti-1351	34	6	,	,	PUNCT
dti-1351	34	7	publisher	publisher	NOUN
dti-1351	34	8	and	and	CCONJ
dti-1351	34	9	licensee	licensee	NOUN
dti-1351	34	10	libertas	liberta	NOUN
dti-1351	34	11	academica	academica	PROPN
dti-1351	34	12	limited	limit	VERB
dti-1351	34	13	.	.	PUNCT
dti-1351	35	1	this	this	PRON
dti-1351	35	2	is	be	AUX
dti-1351	35	3	an	an	DET
dti-1351	35	4	open	open	ADJ
dti-1351	35	5	-	-	PUNCT
dti-1351	35	6	access	access	NOUN
dti-1351	35	7	article	article	NOUN
dti-1351	35	8	distributed	distribute	VERB
dti-1351	35	9	under	under	ADP
dti-1351	35	10	the	the	DET
dti-1351	35	11	terms	term	NOUN
dti-1351	35	12	of	of	ADP
dti-1351	35	13	the	the	DET
dti-1351	35	14	creative	creative	ADJ
dti-1351	35	15	commons	common	NOUN
dti-1351	35	16	ccby	ccby	PROPN
dti-1351	35	17	-	-	PUNCT
dti-1351	35	18	nc	nc	PROPN
dti-1351	35	19	3.0	3.0	NUM
dti-1351	35	20	license	license	NOUN
dti-1351	35	21	.	.	PUNCT
dti-1351	36	1	correspondence	correspondence	NOUN
dti-1351	36	2	:	:	PUNCT
dti-1351	36	3	adnan.mannan@cu.ac.bd	adnan.mannan@cu.ac.bd	VERB
dti-1351	36	4	http://www.la-press.com	http://www.la-press.com	X
dti-1351	36	5	http://www.la-press.com	http://www.la-press.com	X
dti-1351	37	1	http://dx.doi.org/10.4137/dti.s13529	http://dx.doi.org/10.4137/dti.s13529	ADP
dti-1351	37	2	mailto:adnan.mannan@cu.ac.bd	mailto:adnan.mannan@cu.ac.bd	PROPN
dti-1351	37	3	hasan	hasan	PROPN
dti-1351	37	4	et	et	PROPN
dti-1351	37	5	al	al	PROPN
dti-1351	37	6	2	2	NUM
dti-1351	37	7	drug	drug	NOUN
dti-1351	37	8	target	target	NOUN
dti-1351	37	9	insights	insight	NOUN
dti-1351	37	10	2014:8	2014:8	NUM
dti-1351	37	11	and	and	CCONJ
dti-1351	37	12	spread	spread	VERB
dti-1351	37	13	globally	globally	ADV
dti-1351	37	14	via	via	ADP
dti-1351	37	15	shipping	shipping	NOUN
dti-1351	37	16	from	from	ADP
dti-1351	37	17	hong	hong	PROPN
dti-1351	37	18	kong	kong	PROPN
dti-1351	37	19	in	in	ADP
dti-1351	37	20	1894	1894	NUM
dti-1351	37	21	.	.	PUNCT
dti-1351	38	1	the	the	DET
dti-1351	38	2	etiological	etiological	ADJ
dti-1351	38	3	cause	cause	NOUN
dti-1351	38	4	of	of	ADP
dti-1351	38	5	plague	plague	NOUN
dti-1351	38	6	was	be	AUX
dti-1351	38	7	identified	identify	VERB
dti-1351	38	8	as	as	ADP
dti-1351	38	9	yersinia	yersinia	NOUN
dti-1351	38	10	pestis	pestis	PROPN
dti-1351	38	11	during	during	ADP
dti-1351	38	12	this	this	DET
dti-1351	38	13	last	last	ADJ
dti-1351	38	14	pandemic.7	pandemic.7	PROPN
dti-1351	38	15	clinically	clinically	ADV
dti-1351	38	16	,	,	PUNCT
dti-1351	38	17	plague	plague	NOUN
dti-1351	38	18	is	be	AUX
dti-1351	38	19	characterized	characterize	VERB
dti-1351	38	20	by	by	ADP
dti-1351	38	21	swollen	swollen	ADJ
dti-1351	38	22	lymph	lymph	NOUN
dti-1351	38	23	nodes	node	NOUN
dti-1351	38	24	(	(	PUNCT
dti-1351	38	25	bubonic	bubonic	NOUN
dti-1351	38	26	plagues	plague	NOUN
dti-1351	38	27	)	)	PUNCT
dti-1351	38	28	,	,	PUNCT
dti-1351	38	29	fever	fever	NOUN
dti-1351	38	30	,	,	PUNCT
dti-1351	38	31	chills	chill	NOUN
dti-1351	38	32	,	,	PUNCT
dti-1351	38	33	headaches	headache	NOUN
dti-1351	38	34	,	,	PUNCT
dti-1351	38	35	body	body	NOUN
dti-1351	38	36	aches	ache	VERB
dti-1351	38	37	(	(	PUNCT
dti-1351	38	38	septicemic	septicemic	ADJ
dti-1351	38	39	plague	plague	NOUN
dti-1351	38	40	)	)	PUNCT
dti-1351	38	41	,	,	PUNCT
dti-1351	38	42	weakness	weakness	NOUN
dti-1351	38	43	,	,	PUNCT
dti-1351	38	44	vomit­	vomit­	PROPN
dti-1351	38	45	ing	ing	NOUN
dti-1351	38	46	,	,	PUNCT
dti-1351	38	47	and	and	CCONJ
dti-1351	38	48	nausea	nausea	NOUN
dti-1351	38	49	(	(	PUNCT
dti-1351	38	50	pneumonic	pneumonic	ADJ
dti-1351	38	51	plague).8	plague).8	NOUN
dti-1351	38	52	yersinia	yersinia	NOUN
dti-1351	38	53	pestis	pestis	PROPN
dti-1351	38	54	,	,	PUNCT
dti-1351	38	55	is	be	AUX
dti-1351	38	56	a	a	DET
dti-1351	38	57	rod­shaped	rod­shaped	NOUN
dti-1351	38	58	,	,	PUNCT
dti-1351	38	59	coccobacillus	coccobacillus	NOUN
dti-1351	38	60	,	,	PUNCT
dti-1351	38	61	gram	gram	PROPN
dti-1351	38	62	nega­	nega­	PUNCT
dti-1351	38	63	tive	tive	PROPN
dti-1351	38	64	bacterium	bacterium	NOUN
dti-1351	38	65	and	and	CCONJ
dti-1351	38	66	facultative	facultative	ADJ
dti-1351	38	67	anaerobe	anaerobe	NOUN
dti-1351	38	68	that	that	PRON
dti-1351	38	69	infects	infect	VERB
dti-1351	38	70	humans	human	NOUN
dti-1351	38	71	and	and	CCONJ
dti-1351	38	72	animals.9	animals.9	PROPN
dti-1351	38	73	there	there	PRON
dti-1351	38	74	are	be	VERB
dti-1351	38	75	two	two	NUM
dti-1351	38	76	complete	complete	ADJ
dti-1351	38	77	genome	genome	NOUN
dti-1351	38	78	sequences	sequence	NOUN
dti-1351	38	79	for	for	ADP
dti-1351	38	80	two	two	NUM
dti-1351	38	81	of	of	ADP
dti-1351	38	82	three	three	NUM
dti-1351	38	83	subspecies	subspecie	NOUN
dti-1351	38	84	of	of	ADP
dti-1351	38	85	yersinia	yersinia	PROPN
dti-1351	38	86	pestis	pestis	PROPN
dti-1351	38	87	,	,	PUNCT
dti-1351	38	88	strains	strain	VERB
dti-1351	38	89	kim	kim	PROPN
dti-1351	38	90	and	and	CCONJ
dti-1351	38	91	co92	co92	PROPN
dti-1351	38	92	.	.	PUNCT
dti-1351	39	1	the	the	DET
dti-1351	39	2	total	total	ADJ
dti-1351	39	3	size	size	NOUN
dti-1351	39	4	of	of	ADP
dti-1351	39	5	chromosome	chromosome	NOUN
dti-1351	39	6	of	of	ADP
dti-1351	39	7	yersinia	yersinia	PROPN
dti-1351	39	8	pestis	pestis	PROPN
dti-1351	39	9	is	be	AUX
dti-1351	39	10	4,653,728	4,653,728	NUM
dti-1351	39	11	bp	bp	NOUN
dti-1351	39	12	.	.	PUNCT
dti-1351	40	1	gene	gene	NOUN
dti-1351	40	2	acquisition	acquisition	NOUN
dti-1351	40	3	has	have	AUX
dti-1351	40	4	been	be	AUX
dti-1351	40	5	important	important	ADJ
dti-1351	40	6	in	in	ADP
dti-1351	40	7	the	the	DET
dti-1351	40	8	evolution	evolution	NOUN
dti-1351	40	9	of	of	ADP
dti-1351	40	10	yersinia	yersinia	PROPN
dti-1351	40	11	pestis	pestis	PROPN
dti-1351	40	12	.	.	PUNCT
dti-1351	41	1	in	in	ADP
dti-1351	41	2	all	all	DET
dti-1351	41	3	pathogenic	pathogenic	ADJ
dti-1351	41	4	yersinia	yersinia	NOUN
dti-1351	41	5	,	,	PUNCT
dti-1351	41	6	a	a	DET
dti-1351	41	7	70	70	NUM
dti-1351	41	8	kb	kb	PROPN
dti-1351	41	9	virulence	virulence	NOUN
dti-1351	41	10	plasmid	plasmid	NOUN
dti-1351	41	11	(	(	PUNCT
dti-1351	41	12	pyv	pyv	NOUN
dti-1351	41	13	/	/	SYM
dti-1351	41	14	pcd1	pcd1	NOUN
dti-1351	41	15	)	)	PUNCT
dti-1351	41	16	is	be	AUX
dti-1351	41	17	present	present	ADJ
dti-1351	41	18	,	,	PUNCT
dti-1351	41	19	but	but	CCONJ
dti-1351	41	20	yersinia	yersinia	PROPN
dti-1351	41	21	pestis	pestis	PROPN
dti-1351	41	22	has	have	AUX
dti-1351	41	23	acquired	acquire	VERB
dti-1351	41	24	two	two	NUM
dti-1351	41	25	unique	unique	ADJ
dti-1351	41	26	plasmids	plasmid	NOUN
dti-1351	41	27	that	that	PRON
dti-1351	41	28	encode	encode	VERB
dti-1351	41	29	a	a	DET
dti-1351	41	30	variety	variety	NOUN
dti-1351	41	31	of	of	ADP
dti-1351	41	32	virulence	virulence	NOUN
dti-1351	41	33	deter­	deter­	PROPN
dti-1351	41	34	minants.10	minants.10	VERB
dti-1351	41	35	a	a	DET
dti-1351	41	36	9.5	9.5	NUM
dti-1351	41	37	kb	kb	NOUN
dti-1351	41	38	plasmid	plasmid	NOUN
dti-1351	41	39	(	(	PUNCT
dti-1351	41	40	ppst	ppst	VERB
dti-1351	41	41	/	/	SYM
dti-1351	41	42	ppcp1	ppcp1	VERB
dti-1351	41	43	)	)	PUNCT
dti-1351	42	1	encodes	encode	VERB
dti-1351	42	2	the	the	DET
dti-1351	42	3	plas­	plas­	NOUN
dti-1351	42	4	minogen	minogen	ADJ
dti-1351	42	5	activator	activator	NOUN
dti-1351	42	6	pla	pla	NOUN
dti-1351	42	7	and	and	CCONJ
dti-1351	42	8	100–110	100–110	NUM
dti-1351	42	9	kb	kb	PROPN
dti-1351	42	10	plasmid	plasmid	NOUN
dti-1351	42	11	(	(	PUNCT
dti-1351	42	12	pfra	pfra	NOUN
dti-1351	42	13	/	/	SYM
dti-1351	42	14	pmt1	pmt1	NOUN
dti-1351	42	15	)	)	PUNCT
dti-1351	42	16	encodes	encode	NOUN
dti-1351	42	17	murine	murine	ADJ
dti-1351	42	18	toxin	toxin	NOUN
dti-1351	42	19	ymt	ymt	NOUN
dti-1351	43	1	and	and	CCONJ
dti-1351	43	2	the	the	DET
dti-1351	43	3	f1	f1	PROPN
dti-1351	43	4	capsular	capsular	NOUN
dti-1351	43	5	protein.11	protein.11	VERB
dti-1351	43	6	yersinia	yersinia	NOUN
dti-1351	43	7	pestis	pestis	PROPN
dti-1351	43	8	harbors	harbor	VERB
dti-1351	43	9	a	a	DET
dti-1351	43	10	70	70	NUM
dti-1351	43	11	kb	kb	NOUN
dti-1351	43	12	extra	extra	ADJ
dti-1351	43	13	chromosomal	chromosomal	ADJ
dti-1351	43	14	plas­	plas­	NOUN
dti-1351	43	15	mid	mid	ADJ
dti-1351	43	16	dna	dna	NOUN
dti-1351	43	17	that	that	PRON
dti-1351	43	18	encodes	encode	VERB
dti-1351	43	19	type	type	NOUN
dti-1351	43	20	iii	iii	NUM
dti-1351	43	21	secretion	secretion	NOUN
dti-1351	43	22	system	system	NOUN
dti-1351	43	23	(	(	PUNCT
dti-1351	43	24	t3ss	t3ss	NOUN
dti-1351	43	25	)	)	PUNCT
dti-1351	43	26	,	,	PUNCT
dti-1351	43	27	which	which	PRON
dti-1351	43	28	is	be	AUX
dti-1351	43	29	one	one	NUM
dti-1351	43	30	of	of	ADP
dti-1351	43	31	the	the	DET
dti-1351	43	32	most	most	ADV
dti-1351	43	33	important	important	ADJ
dti-1351	43	34	virulence	virulence	NOUN
dti-1351	43	35	mechanisms	mechanism	NOUN
dti-1351	43	36	of	of	ADP
dti-1351	43	37	the	the	DET
dti-1351	43	38	lethal	lethal	ADJ
dti-1351	43	39	plague	plague	NOUN
dti-1351	43	40	pathogen.12	pathogen.12	NOUN
dti-1351	43	41	this	this	PRON
dti-1351	43	42	t3ss	t3ss	PUNCT
dti-1351	43	43	consists	consist	VERB
dti-1351	43	44	of	of	ADP
dti-1351	43	45	a	a	DET
dti-1351	43	46	sophisti­	sophisti­	ADJ
dti-1351	43	47	cated	cat	VERB
dti-1351	43	48	translocation	translocation	NOUN
dti-1351	43	49	apparatus	apparatus	NOUN
dti-1351	43	50	that	that	PRON
dti-1351	43	51	is	be	AUX
dti-1351	43	52	highly	highly	ADV
dti-1351	43	53	conserved	conserved	ADJ
dti-1351	43	54	among	among	ADP
dti-1351	43	55	a	a	DET
dti-1351	43	56	number	number	NOUN
dti-1351	43	57	of	of	ADP
dti-1351	43	58	gram­negative	gram­negative	ADJ
dti-1351	43	59	pathogenic	pathogenic	ADJ
dti-1351	43	60	bacteria.13	bacteria.13	NOUN
dti-1351	43	61	to	to	PART
dti-1351	43	62	contact	contact	VERB
dti-1351	43	63	with	with	ADP
dti-1351	43	64	the	the	DET
dti-1351	43	65	host	host	NOUN
dti-1351	43	66	cell	cell	NOUN
dti-1351	43	67	’s	’s	PART
dti-1351	43	68	receptor	receptor	NOUN
dti-1351	43	69	,	,	PUNCT
dti-1351	43	70	the	the	DET
dti-1351	43	71	type	type	NOUN
dti-1351	43	72	iii	iii	NUM
dti-1351	43	73	secretion	secretion	NOUN
dti-1351	43	74	system	system	NOUN
dti-1351	43	75	of	of	ADP
dti-1351	43	76	yersinia	yersinia	NOUN
dti-1351	43	77	delivers	deliver	VERB
dti-1351	43	78	a	a	DET
dti-1351	43	79	set	set	NOUN
dti-1351	43	80	of	of	ADP
dti-1351	43	81	effector	effector	NOUN
dti-1351	43	82	proteins	protein	NOUN
dti-1351	43	83	termed	term	VERB
dti-1351	43	84	yops	yop	NOUN
dti-1351	43	85	(	(	PUNCT
dti-1351	43	86	yersinia	yersinia	NOUN
dti-1351	43	87	outer	outer	ADJ
dti-1351	43	88	proteins	protein	NOUN
dti-1351	43	89	)	)	PUNCT
dti-1351	43	90	into	into	ADP
dti-1351	43	91	the	the	DET
dti-1351	43	92	host	host	NOUN
dti-1351	43	93	cell	cell	NOUN
dti-1351	43	94	.	.	PUNCT
dti-1351	44	1	to	to	ADP
dti-1351	44	2	date	date	NOUN
dti-1351	44	3	,	,	PUNCT
dti-1351	44	4	six	six	NUM
dti-1351	44	5	yop	yop	NOUN
dti-1351	44	6	effectors	effector	NOUN
dti-1351	44	7	(	(	PUNCT
dti-1351	44	8	yoph	yoph	PROPN
dti-1351	44	9	,	,	PUNCT
dti-1351	44	10	yope	yope	NOUN
dti-1351	44	11	,	,	PUNCT
dti-1351	44	12	yopj	yopj	NOUN
dti-1351	44	13	/	/	SYM
dti-1351	44	14	p	p	NOUN
dti-1351	44	15	,	,	PUNCT
dti-1351	44	16	ypka	ypka	PROPN
dti-1351	44	17	/	/	SYM
dti-1351	44	18	yopo	yopo	NOUN
dti-1351	44	19	,	,	PUNCT
dti-1351	44	20	yopt	yopt	VERB
dti-1351	44	21	,	,	PUNCT
dti-1351	44	22	and	and	CCONJ
dti-1351	44	23	yopm	yopm	NOUN
dti-1351	44	24	)	)	PUNCT
dti-1351	44	25	have	have	AUX
dti-1351	44	26	been	be	AUX
dti-1351	44	27	identified	identify	VERB
dti-1351	44	28	.	.	PUNCT
dti-1351	45	1	they	they	PRON
dti-1351	45	2	function	function	VERB
dti-1351	45	3	to	to	PART
dti-1351	45	4	attenuate	attenuate	VERB
dti-1351	45	5	the	the	DET
dti-1351	45	6	host	host	NOUN
dti-1351	45	7	’s	’s	PART
dti-1351	45	8	immune	immune	ADJ
dti-1351	45	9	response	response	NOUN
dti-1351	45	10	during	during	ADP
dti-1351	45	11	infection	infection	NOUN
dti-1351	45	12	,	,	PUNCT
dti-1351	45	13	and	and	CCONJ
dti-1351	45	14	phagocytes	phagocyte	NOUN
dti-1351	45	15	are	be	AUX
dti-1351	45	16	the	the	DET
dti-1351	45	17	main	main	ADJ
dti-1351	45	18	tar­	tar­	NOUN
dti-1351	45	19	get	get	NOUN
dti-1351	45	20	of	of	ADP
dti-1351	45	21	t3ss	t3ss	PUNCT
dti-1351	45	22	for	for	ADP
dti-1351	45	23	these	these	DET
dti-1351	45	24	yops	yop	NOUN
dti-1351	45	25	effector	effector	NOUN
dti-1351	45	26	injections.14	injections.14	VERB
dti-1351	45	27	at	at	ADV
dti-1351	45	28	least	least	ADV
dti-1351	45	29	four	four	NUM
dti-1351	45	30	yops­yoph	yops­yoph	NOUN
dti-1351	45	31	,	,	PUNCT
dti-1351	45	32	yope	yope	NOUN
dti-1351	45	33	,	,	PUNCT
dti-1351	45	34	yopo	yopo	NOUN
dti-1351	45	35	and	and	CCONJ
dti-1351	45	36	yopt	yopt	VERB
dti-1351	45	37	,	,	PUNCT
dti-1351	45	38	are	be	AUX
dti-1351	45	39	involved	involve	VERB
dti-1351	45	40	in	in	ADP
dti-1351	45	41	inhib­	inhib­	NOUN
dti-1351	45	42	iting	iting	NOUN
dti-1351	45	43	phagocytosis	phagocytosis	NOUN
dti-1351	45	44	,	,	PUNCT
dti-1351	45	45	either	either	CCONJ
dti-1351	45	46	by	by	ADP
dti-1351	45	47	targeting	target	VERB
dti-1351	45	48	the	the	DET
dti-1351	45	49	host	host	NOUN
dti-1351	45	50	cell	cell	NOUN
dti-1351	45	51	’s	’s	PART
dti-1351	45	52	actin	actin	NOUN
dti-1351	45	53	regulation	regulation	NOUN
dti-1351	45	54	of	of	ADP
dti-1351	45	55	rho	rho	ADJ
dti-1351	45	56	gtpase	gtpase	NOUN
dti-1351	45	57	(	(	PUNCT
dti-1351	45	58	yopt	yopt	PROPN
dti-1351	45	59	,	,	PUNCT
dti-1351	45	60	yope	yope	NOUN
dti-1351	45	61	,	,	PUNCT
dti-1351	45	62	yopo	yopo	NOUN
dti-1351	45	63	)	)	PUNCT
dti-1351	45	64	or	or	CCONJ
dti-1351	45	65	by	by	ADP
dti-1351	45	66	rapidly	rapidly	ADV
dti-1351	45	67	and	and	CCONJ
dti-1351	45	68	specifically	specifically	ADV
dti-1351	45	69	targeting	target	VERB
dti-1351	45	70	host	host	NOUN
dti-1351	45	71	proteins	protein	NOUN
dti-1351	45	72	associated	associate	VERB
dti-1351	45	73	with	with	ADP
dti-1351	45	74	sig­	sig­	PROPN
dti-1351	45	75	nal	nal	PROPN
dti-1351	45	76	transducing	transducing	NOUN
dti-1351	45	77	from	from	ADP
dti-1351	45	78	receptor	receptor	NOUN
dti-1351	45	79	to	to	ADP
dti-1351	45	80	actin	actin	NOUN
dti-1351	45	81	(	(	PUNCT
dti-1351	45	82	yoph	yoph	PROPN
dti-1351	45	83	)	)	PUNCT
dti-1351	45	84	,	,	PUNCT
dti-1351	45	85	which	which	PRON
dti-1351	45	86	is	be	AUX
dti-1351	45	87	also	also	ADV
dti-1351	45	88	responsible	responsible	ADJ
dti-1351	45	89	for	for	ADP
dti-1351	45	90	suppressing	suppress	VERB
dti-1351	45	91	reactive	reactive	ADJ
dti-1351	45	92	oxygen	oxygen	NOUN
dti-1351	45	93	intermediates	intermediate	NOUN
dti-1351	45	94	pro­	pro­	VERB
dti-1351	45	95	duction	duction	NOUN
dti-1351	45	96	by	by	ADP
dti-1351	45	97	macrophages	macrophage	NOUN
dti-1351	45	98	and	and	CCONJ
dti-1351	45	99	pmns.15,16	pmns.15,16	VERB
dti-1351	45	100	our	our	PRON
dti-1351	45	101	targeted	target	VERB
dti-1351	45	102	study	study	NOUN
dti-1351	45	103	is	be	AUX
dti-1351	45	104	on	on	ADP
dti-1351	45	105	yopt	yopt	NOUN
dti-1351	45	106	,	,	PUNCT
dti-1351	45	107	also	also	ADV
dti-1351	45	108	known	know	VERB
dti-1351	45	109	as	as	ADP
dti-1351	45	110	cysteine	cysteine	NOUN
dti-1351	45	111	protease	protease	NOUN
dti-1351	45	112	,	,	PUNCT
dti-1351	45	113	which	which	PRON
dti-1351	45	114	induces	induce	VERB
dti-1351	45	115	cytotoxicity	cytotoxicity	NOUN
dti-1351	45	116	in	in	ADP
dti-1351	45	117	mammalian	mammalian	ADJ
dti-1351	45	118	cells	cell	NOUN
dti-1351	45	119	.	.	PUNCT
dti-1351	46	1	this	this	DET
dti-1351	46	2	cytotoxicity	cytotoxicity	NOUN
dti-1351	46	3	is	be	AUX
dti-1351	46	4	charac­	charac­	VERB
dti-1351	46	5	terized	terize	VERB
dti-1351	46	6	by	by	ADP
dti-1351	46	7	disruption	disruption	NOUN
dti-1351	46	8	of	of	ADP
dti-1351	46	9	the	the	DET
dti-1351	46	10	cytoskeleton	cytoskeleton	PROPN
dti-1351	46	11	as	as	ADV
dti-1351	46	12	well	well	ADV
dti-1351	46	13	as	as	ADP
dti-1351	46	14	rounding	round	VERB
dti-1351	46	15	up	up	ADP
dti-1351	46	16	cells.17	cells.17	PROPN
dti-1351	46	17	disruption	disruption	NOUN
dti-1351	46	18	of	of	ADP
dti-1351	46	19	the	the	DET
dti-1351	46	20	host	host	NOUN
dti-1351	46	21	cell	cell	NOUN
dti-1351	46	22	cytoskeleton	cytoskeleton	NOUN
dti-1351	46	23	by	by	ADP
dti-1351	46	24	cysteine	cysteine	NOUN
dti-1351	46	25	protease	protease	NOUN
dti-1351	46	26	yopt	yopt	PROPN
dti-1351	46	27	contributes	contribute	VERB
dti-1351	46	28	to	to	ADP
dti-1351	46	29	the	the	DET
dti-1351	46	30	antiphagocytic	antiphagocytic	ADJ
dti-1351	46	31	effect	effect	NOUN
dti-1351	46	32	of	of	ADP
dti-1351	46	33	yersinia	yersinia	NOUN
dti-1351	46	34	.	.	PUNCT
dti-1351	47	1	though	though	SCONJ
dti-1351	47	2	biochemical	biochemical	ADJ
dti-1351	47	3	function	function	NOUN
dti-1351	47	4	of	of	ADP
dti-1351	47	5	cysteine	cysteine	NOUN
dti-1351	47	6	protease	protease	NOUN
dti-1351	47	7	yopt	yopt	NOUN
dti-1351	47	8	is	be	AUX
dti-1351	47	9	poorly	poorly	ADV
dti-1351	47	10	understood	understand	VERB
dti-1351	47	11	,	,	PUNCT
dti-1351	47	12	it	it	PRON
dti-1351	47	13	is	be	AUX
dti-1351	47	14	conserved	conserve	VERB
dti-1351	47	15	in	in	ADP
dti-1351	47	16	all	all	DET
dti-1351	47	17	yersinia	yersinia	NOUN
dti-1351	47	18	spe­	spe­	NOUN
dti-1351	47	19	cies	cie	NOUN
dti-1351	47	20	,	,	PUNCT
dti-1351	47	21	suggesting	suggest	VERB
dti-1351	47	22	that	that	SCONJ
dti-1351	47	23	it	it	PRON
dti-1351	47	24	is	be	AUX
dti-1351	47	25	important	important	ADJ
dti-1351	47	26	in	in	ADP
dti-1351	47	27	pathogenesis.18	pathogenesis.18	ADJ
dti-1351	47	28	cysteine	cysteine	NOUN
dti-1351	47	29	protease	protease	NOUN
dti-1351	47	30	yopt	yopt	PROPN
dti-1351	47	31	also	also	ADV
dti-1351	47	32	induces	induce	VERB
dti-1351	47	33	an	an	DET
dti-1351	47	34	isoelectric	isoelectric	ADJ
dti-1351	47	35	point	point	NOUN
dti-1351	47	36	shift	shift	NOUN
dti-1351	47	37	of	of	ADP
dti-1351	47	38	rhoa	rhoa	PROPN
dti-1351	47	39	,	,	PUNCT
dti-1351	47	40	a	a	DET
dti-1351	47	41	small	small	ADJ
dti-1351	47	42	gtpase	gtpase	NOUN
dti-1351	47	43	known	know	VERB
dti-1351	47	44	to	to	PART
dti-1351	47	45	regulate	regulate	VERB
dti-1351	47	46	the	the	DET
dti-1351	47	47	actin	actin	NOUN
dti-1351	47	48	cytoskeleton.19	cytoskeleton.19	PROPN
dti-1351	47	49	yopt	yopt	PROPN
dti-1351	47	50	causes	cause	VERB
dti-1351	47	51	the	the	DET
dti-1351	47	52	release	release	NOUN
dti-1351	47	53	of	of	ADP
dti-1351	47	54	rhoa	rhoa	PROPN
dti-1351	47	55	from	from	ADP
dti-1351	47	56	cell	cell	NOUN
dti-1351	47	57	membranes	membrane	NOUN
dti-1351	47	58	or	or	CCONJ
dti-1351	47	59	arti­	arti­	NOUN
dti-1351	47	60	ficial	ficial	ADJ
dti-1351	47	61	vesicles	vesicle	NOUN
dti-1351	47	62	.	.	PUNCT
dti-1351	48	1	additional	additional	ADJ
dti-1351	48	2	insights	insight	NOUN
dti-1351	48	3	into	into	ADP
dti-1351	48	4	the	the	DET
dti-1351	48	5	function	function	NOUN
dti-1351	48	6	of	of	ADP
dti-1351	48	7	cysteine	cysteine	NOUN
dti-1351	48	8	protease	protease	NOUN
dti-1351	48	9	yopt	yopt	PROPN
dti-1351	48	10	were	be	AUX
dti-1351	48	11	obtained	obtain	VERB
dti-1351	48	12	from	from	ADP
dti-1351	48	13	the	the	DET
dti-1351	48	14	observation	observation	NOUN
dti-1351	48	15	that	that	SCONJ
dti-1351	48	16	rho	rho	ADJ
dti-1351	48	17	family	family	NOUN
dti-1351	48	18	gtpases	gtpase	NOUN
dti-1351	48	19	,	,	PUNCT
dti-1351	48	20	including	include	VERB
dti-1351	48	21	rac	rac	PROPN
dti-1351	48	22	,	,	PUNCT
dti-1351	48	23	rhoa	rhoa	PROPN
dti-1351	48	24	,	,	PUNCT
dti-1351	48	25	and	and	CCONJ
dti-1351	48	26	cdc42	cdc42	PROPN
dti-1351	48	27	,	,	PUNCT
dti-1351	48	28	are	be	AUX
dti-1351	48	29	all	all	PRON
dti-1351	48	30	known	known	ADJ
dti-1351	48	31	to	to	PART
dti-1351	48	32	undergo	undergo	VERB
dti-1351	48	33	post­translational	post­translational	ADJ
dti-1351	48	34	modifications	modification	NOUN
dti-1351	48	35	in	in	ADP
dti-1351	48	36	a	a	DET
dti-1351	48	37	sequen­	sequen­	PROPN
dti-1351	48	38	tial	tial	ADJ
dti-1351	48	39	manner	manner	NOUN
dti-1351	48	40	at	at	ADP
dti-1351	48	41	their	their	PRON
dti-1351	48	42	c­terminal	c­terminal	ADJ
dti-1351	48	43	caax	caax	PROPN
dti-1351	48	44	box	box	PROPN
dti-1351	48	45	(	(	PUNCT
dti-1351	48	46	c	c	PROPN
dti-1351	48	47	,	,	PUNCT
dti-1351	48	48	cysteine	cysteine	NOUN
dti-1351	48	49	;	;	PUNCT
dti-1351	48	50	a	a	DET
dti-1351	48	51	,	,	PUNCT
dti-1351	48	52	aliphatic	aliphatic	ADJ
dti-1351	48	53	residue	residue	NOUN
dti-1351	48	54	;	;	PUNCT
dti-1351	48	55	x	x	X
dti-1351	48	56	,	,	PUNCT
dti-1351	48	57	any	any	DET
dti-1351	48	58	residue).20	residue).20	PROPN
dti-1351	48	59	the	the	DET
dti-1351	48	60	caax	caax	PROPN
dti-1351	48	61	box	box	PROPN
dti-1351	48	62	provides	provide	VERB
dti-1351	48	63	the	the	DET
dti-1351	48	64	recognition	recognition	NOUN
dti-1351	48	65	elements	element	NOUN
dti-1351	48	66	for	for	ADP
dti-1351	48	67	prenylation	prenylation	NOUN
dti-1351	48	68	of	of	ADP
dti-1351	48	69	the	the	DET
dti-1351	48	70	cysteine.21	cysteine.21	PROPN
dti-1351	48	71	cysteine	cysteine	NOUN
dti-1351	48	72	protease	protease	NOUN
dti-1351	48	73	yopt	yopt	PROPN
dti-1351	48	74	carries	carry	VERB
dti-1351	48	75	out	out	ADP
dti-1351	48	76	a	a	DET
dti-1351	48	77	proteolytic	proteolytic	ADJ
dti-1351	48	78	cleavage	cleavage	NOUN
dti-1351	48	79	near	near	ADP
dti-1351	48	80	the	the	DET
dti-1351	48	81	c	c	PROPN
dti-1351	48	82	termini	termini	NOUN
dti-1351	48	83	of	of	ADP
dti-1351	48	84	rhoa	rhoa	PROPN
dti-1351	48	85	,	,	PUNCT
dti-1351	48	86	rac1	rac1	PROPN
dti-1351	48	87	,	,	PUNCT
dti-1351	48	88	cdc42	cdc42	PROPN
dti-1351	48	89	.	.	PUNCT
dti-1351	49	1	this	this	DET
dti-1351	49	2	cleavage	cleavage	NOUN
dti-1351	49	3	results	result	NOUN
dti-1351	49	4	in	in	ADP
dti-1351	49	5	the	the	DET
dti-1351	49	6	removal	removal	NOUN
dti-1351	49	7	of	of	ADP
dti-1351	49	8	the	the	DET
dti-1351	49	9	lipid	lipid	NOUN
dti-1351	49	10	modification	modification	NOUN
dti-1351	49	11	(	(	PUNCT
dti-1351	49	12	by	by	ADP
dti-1351	49	13	removal	removal	NOUN
dti-1351	49	14	of	of	ADP
dti-1351	49	15	prenylated	prenylate	VERB
dti-1351	49	16	group	group	NOUN
dti-1351	49	17	)	)	PUNCT
dti-1351	49	18	from	from	ADP
dti-1351	49	19	the	the	DET
dti-1351	49	20	gtpase	gtpase	NOUN
dti-1351	49	21	at	at	ADP
dti-1351	49	22	their	their	PRON
dti-1351	49	23	c­termini	c­termini	NOUN
dti-1351	49	24	,	,	PUNCT
dti-1351	49	25	which	which	PRON
dti-1351	49	26	leads	lead	VERB
dti-1351	49	27	to	to	ADP
dti-1351	49	28	their	their	PRON
dti-1351	49	29	subsequent	subsequent	ADJ
dti-1351	49	30	membrane	membrane	NOUN
dti-1351	49	31	detachment	detachment	NOUN
dti-1351	49	32	.	.	PUNCT
dti-1351	50	1	by	by	ADP
dti-1351	50	2	this	this	DET
dti-1351	50	3	mechanism	mechanism	NOUN
dti-1351	50	4	yopt	yopt	PROPN
dti-1351	50	5	impairs	impair	VERB
dti-1351	50	6	the	the	DET
dti-1351	50	7	ability	ability	NOUN
dti-1351	50	8	of	of	ADP
dti-1351	50	9	host	host	NOUN
dti-1351	50	10	cell	cell	NOUN
dti-1351	50	11	to	to	PART
dti-1351	50	12	execute	execute	VERB
dti-1351	50	13	phagocytosis	phagocytosis	NOUN
dti-1351	50	14	and	and	CCONJ
dti-1351	50	15	bacterial	bacterial	ADJ
dti-1351	50	16	cell	cell	NOUN
dti-1351	50	17	internalization	internalization	NOUN
dti-1351	50	18	by	by	ADP
dti-1351	50	19	causing	cause	VERB
dti-1351	50	20	cytoskeletal	cytoskeletal	ADJ
dti-1351	50	21	rear­	rear­	ADJ
dti-1351	50	22	rangement	rangement	NOUN
dti-1351	50	23	of	of	ADP
dti-1351	50	24	phagocytic	phagocytic	ADJ
dti-1351	50	25	cell	cell	NOUN
dti-1351	50	26	.	.	PUNCT
dti-1351	51	1	cleavage	cleavage	NOUN
dti-1351	51	2	of	of	ADP
dti-1351	51	3	the	the	DET
dti-1351	51	4	rho	rho	ADJ
dti-1351	51	5	gtpase	gtpase	NOUN
dti-1351	51	6	by	by	ADP
dti-1351	51	7	yopt	yopt	PROPN
dti-1351	51	8	is	be	AUX
dti-1351	51	9	responsible	responsible	ADJ
dti-1351	51	10	for	for	ADP
dti-1351	51	11	the	the	DET
dti-1351	51	12	disruption	disruption	NOUN
dti-1351	51	13	of	of	ADP
dti-1351	51	14	actin	actin	NOUN
dti-1351	51	15	cytoskeleton	cytoskeleton	PROPN
dti-1351	51	16	as	as	ADV
dti-1351	51	17	well	well	ADV
dti-1351	51	18	as	as	ADP
dti-1351	51	19	the	the	DET
dti-1351	51	20	proteolytic	proteolytic	ADJ
dti-1351	51	21	activity	activity	NOUN
dti-1351	51	22	of	of	ADP
dti-1351	51	23	cysteine	cysteine	NOUN
dti-1351	51	24	protease	protease	NOUN
dti-1351	51	25	yopt	yopt	NOUN
dti-1351	51	26	,	,	PUNCT
dti-1351	51	27	which	which	PRON
dti-1351	51	28	is	be	AUX
dti-1351	51	29	dependent	dependent	ADJ
dti-1351	51	30	upon	upon	SCONJ
dti-1351	51	31	the	the	DET
dti-1351	51	32	invariant	invariant	PROPN
dti-1351	51	33	cys	cys	PROPN
dti-1351	51	34	,	,	PUNCT
dti-1351	51	35	his	his	PRON
dti-1351	51	36	,	,	PUNCT
dti-1351	51	37	asp	asp	PROPN
dti-1351	51	38	resi­	resi­	PROPN
dti-1351	51	39	dues	due	NOUN
dti-1351	51	40	that	that	PRON
dti-1351	51	41	are	be	AUX
dti-1351	51	42	conserved	conserve	VERB
dti-1351	51	43	in	in	ADP
dti-1351	51	44	a	a	DET
dti-1351	51	45	novel	novel	ADJ
dti-1351	51	46	family	family	NOUN
dti-1351	51	47	of	of	ADP
dti-1351	51	48	cysteine	cysteine	NOUN
dti-1351	51	49	proteases	protease	NOUN
dti-1351	51	50	involved	involve	VERB
dti-1351	51	51	in	in	ADP
dti-1351	51	52	both	both	CCONJ
dti-1351	51	53	animal	animal	NOUN
dti-1351	51	54	and	and	CCONJ
dti-1351	51	55	plant	plant	VERB
dti-1351	51	56	bacterial	bacterial	ADJ
dti-1351	51	57	pathogenesis.19	pathogenesis.19	NOUN
dti-1351	51	58	our	our	PRON
dti-1351	51	59	present	present	ADJ
dti-1351	51	60	study	study	NOUN
dti-1351	51	61	aims	aim	VERB
dti-1351	51	62	to	to	PART
dti-1351	51	63	predict	predict	VERB
dti-1351	51	64	the	the	DET
dti-1351	51	65	3d	3d	NUM
dti-1351	51	66	structure	structure	NOUN
dti-1351	51	67	of	of	ADP
dti-1351	51	68	cysteine	cysteine	NOUN
dti-1351	51	69	protease	protease	NOUN
dti-1351	51	70	yopt	yopt	NOUN
dti-1351	51	71	,	,	PUNCT
dti-1351	51	72	finding	find	VERB
dti-1351	51	73	out	out	ADP
dti-1351	51	74	its	its	PRON
dti-1351	51	75	interacting	interact	VERB
dti-1351	51	76	networks	network	NOUN
dti-1351	51	77	,	,	PUNCT
dti-1351	51	78	and	and	CCONJ
dti-1351	51	79	also	also	ADV
dti-1351	51	80	to	to	PART
dti-1351	51	81	predict	predict	VERB
dti-1351	51	82	the	the	DET
dti-1351	51	83	active	active	ADJ
dti-1351	51	84	sites	site	NOUN
dti-1351	51	85	of	of	ADP
dti-1351	51	86	cysteine	cysteine	NOUN
dti-1351	51	87	protease	protease	NOUN
dti-1351	51	88	yopt	yopt	NOUN
dti-1351	51	89	for	for	ADP
dti-1351	51	90	pos­	pos­	ADJ
dti-1351	51	91	sible	sible	ADJ
dti-1351	51	92	drug	drug	NOUN
dti-1351	51	93	target	target	NOUN
dti-1351	51	94	by	by	ADP
dti-1351	51	95	computer	computer	NOUN
dti-1351	51	96	simulation	simulation	NOUN
dti-1351	51	97	.	.	PUNCT
dti-1351	52	1	materials	material	NOUN
dti-1351	52	2	and	and	CCONJ
dti-1351	52	3	methods	method	NOUN
dti-1351	52	4	sequence	sequence	NOUN
dti-1351	52	5	retrieval	retrieval	NOUN
dti-1351	52	6	.	.	PUNCT
dti-1351	53	1	a	a	DET
dti-1351	53	2	sequence	sequence	NOUN
dti-1351	53	3	of	of	ADP
dti-1351	53	4	cysteine	cysteine	NOUN
dti-1351	53	5	protease	protease	NOUN
dti-1351	53	6	yopt	yopt	PROPN
dti-1351	53	7	in	in	ADP
dti-1351	53	8	yersinia	yersinia	PROPN
dti-1351	53	9	pestis	pestis	PROPN
dti-1351	53	10	was	be	AUX
dti-1351	53	11	retrieved	retrieve	VERB
dti-1351	53	12	from	from	ADP
dti-1351	53	13	the	the	DET
dti-1351	53	14	uniprot	uniprot	ADJ
dti-1351	53	15	knowledge	knowledge	NOUN
dti-1351	53	16	base	base	NOUN
dti-1351	53	17	(	(	PUNCT
dti-1351	53	18	uniprotkb	uniprotkb	NOUN
dti-1351	53	19	)	)	PUNCT
dti-1351	53	20	,	,	PUNCT
dti-1351	53	21	which	which	PRON
dti-1351	53	22	is	be	AUX
dti-1351	53	23	the	the	DET
dti-1351	53	24	central	central	ADJ
dti-1351	53	25	hub	hub	NOUN
dti-1351	53	26	for	for	ADP
dti-1351	53	27	the	the	DET
dti-1351	53	28	collection	collection	NOUN
dti-1351	53	29	of	of	ADP
dti-1351	53	30	functional	functional	ADJ
dti-1351	53	31	information	information	NOUN
dti-1351	53	32	on	on	ADP
dti-1351	53	33	proteins	protein	NOUN
dti-1351	53	34	,	,	PUNCT
dti-1351	53	35	with	with	ADP
dti-1351	53	36	consistent	consistent	ADJ
dti-1351	53	37	,	,	PUNCT
dti-1351	53	38	accu­	accu­	NOUN
dti-1351	53	39	rate	rate	NOUN
dti-1351	53	40	and	and	CCONJ
dti-1351	53	41	rich	rich	ADJ
dti-1351	53	42	annotation	annotation	NOUN
dti-1351	53	43	.	.	PUNCT
dti-1351	54	1	the	the	DET
dti-1351	54	2	accession	accession	NOUN
dti-1351	54	3	i	i	PROPN
dti-1351	54	4	d	d	PROPN
dti-1351	54	5	of	of	ADP
dti-1351	54	6	cysteine	cysteine	NOUN
dti-1351	54	7	protease	protease	NOUN
dti-1351	54	8	is	be	AUX
dti-1351	54	9	o68703	o68703	ADJ
dti-1351	54	10	[	[	X
dti-1351	54	11	uniparc	uniparc	NOUN
dti-1351	54	12	]	]	PUNCT
dti-1351	54	13	and	and	CCONJ
dti-1351	54	14	it	it	PRON
dti-1351	54	15	contains	contain	VERB
dti-1351	54	16	322	322	NUM
dti-1351	54	17	amino	amino	NOUN
dti-1351	54	18	acids	acid	NOUN
dti-1351	54	19	.	.	PUNCT
dti-1351	55	1	physiochemical	physiochemical	ADJ
dti-1351	55	2	properties	property	NOUN
dti-1351	55	3	analysis	analysis	VERB
dti-1351	55	4	.	.	PUNCT
dti-1351	56	1	the	the	DET
dti-1351	56	2	amino	amino	NOUN
dti-1351	56	3	acid	acid	NOUN
dti-1351	56	4	composition	composition	NOUN
dti-1351	56	5	,	,	PUNCT
dti-1351	56	6	theoretical	theoretical	ADJ
dti-1351	56	7	isoelectric	isoelectric	ADJ
dti-1351	56	8	point	point	NOUN
dti-1351	56	9	(	(	PUNCT
dti-1351	56	10	pi	pi	NOUN
dti-1351	56	11	)	)	PUNCT
dti-1351	56	12	,	,	PUNCT
dti-1351	56	13	molecular	molecular	ADJ
dti-1351	56	14	weight	weight	NOUN
dti-1351	56	15	,	,	PUNCT
dti-1351	56	16	number	number	NOUN
dti-1351	56	17	of	of	ADP
dti-1351	56	18	positively	positively	ADV
dti-1351	56	19	and	and	CCONJ
dti-1351	56	20	negatively	negatively	ADV
dti-1351	56	21	charged	charge	VERB
dti-1351	56	22	resi­	resi­	NOUN
dti-1351	56	23	dues	due	NOUN
dti-1351	56	24	,	,	PUNCT
dti-1351	56	25	instability	instability	NOUN
dti-1351	56	26	and	and	CCONJ
dti-1351	56	27	aliphatic	aliphatic	ADJ
dti-1351	56	28	index	index	NOUN
dti-1351	56	29	,	,	PUNCT
dti-1351	56	30	extinction	extinction	NOUN
dti-1351	56	31	coefficient	coefficient	NOUN
dti-1351	56	32	and	and	CCONJ
dti-1351	56	33	grand	grand	ADJ
dti-1351	56	34	average	average	NOUN
dti-1351	56	35	of	of	ADP
dti-1351	56	36	hydropathy	hydropathy	ADJ
dti-1351	56	37	(	(	PUNCT
dti-1351	56	38	gravy	gravy	NOUN
dti-1351	56	39	)	)	PUNCT
dti-1351	56	40	was	be	AUX
dti-1351	56	41	assessed	assess	VERB
dti-1351	56	42	by	by	ADP
dti-1351	56	43	protparam	protparam	PROPN
dti-1351	56	44	[	[	X
dti-1351	56	45	http://web.expasy.org/protparam/	http://web.expasy.org/protparam/	X
dti-1351	56	46	]	]	X
dti-1351	56	47	.	.	PUNCT
dti-1351	57	1	functional	functional	ADJ
dti-1351	57	2	properties	property	NOUN
dti-1351	57	3	analysis	analysis	NOUN
dti-1351	57	4	.	.	PUNCT
dti-1351	58	1	for	for	ADP
dti-1351	58	2	functional	functional	ADJ
dti-1351	58	3	analysis	analysis	NOUN
dti-1351	58	4	of	of	ADP
dti-1351	58	5	this	this	DET
dti-1351	58	6	protein	protein	NOUN
dti-1351	58	7	,	,	PUNCT
dti-1351	58	8	a	a	DET
dti-1351	58	9	specialized	specialized	ADJ
dti-1351	58	10	tool	tool	NOUN
dti-1351	58	11	pfp	pfp	PROPN
dti-1351	58	12	from	from	ADP
dti-1351	58	13	kihara	kihara	PROPN
dti-1351	58	14	bioin­	bioin­	PROPN
dti-1351	58	15	formatics	formatics	PROPN
dti-1351	58	16	laboratory	laboratory	NOUN
dti-1351	58	17	(	(	PUNCT
dti-1351	58	18	http://kiharalab.org/web/pfp.php	http://kiharalab.org/web/pfp.php	PROPN
dti-1351	58	19	)	)	PUNCT
dti-1351	58	20	was	be	AUX
dti-1351	58	21	used	use	VERB
dti-1351	58	22	.	.	PUNCT
dti-1351	59	1	the	the	DET
dti-1351	59	2	retrieved	retrieve	VERB
dti-1351	59	3	amino	amino	NOUN
dti-1351	59	4	acid	acid	NOUN
dti-1351	59	5	sequence	sequence	NOUN
dti-1351	59	6	in	in	ADP
dti-1351	59	7	fasta	fasta	PROPN
dti-1351	59	8	format	format	NOUN
dti-1351	59	9	was	be	AUX
dti-1351	59	10	used	use	VERB
dti-1351	59	11	as	as	ADP
dti-1351	59	12	input	input	NOUN
dti-1351	59	13	data	datum	NOUN
dti-1351	59	14	.	.	PUNCT
dti-1351	60	1	prediction	prediction	NOUN
dti-1351	60	2	of	of	ADP
dti-1351	60	3	disease	disease	NOUN
dti-1351	60	4	causing	cause	VERB
dti-1351	60	5	regions	region	NOUN
dti-1351	60	6	and	and	CCONJ
dti-1351	60	7	proteolytic	proteolytic	ADJ
dti-1351	60	8	cleavage	cleavage	NOUN
dti-1351	60	9	sites	site	NOUN
dti-1351	60	10	.	.	PUNCT
dti-1351	61	1	globplot	globplot	ADP
dti-1351	61	2	2.322	2.322	NUM
dti-1351	61	3	was	be	AUX
dti-1351	61	4	used	use	VERB
dti-1351	61	5	for	for	ADP
dti-1351	61	6	the	the	DET
dti-1351	61	7	prediction	prediction	NOUN
dti-1351	61	8	of	of	ADP
dti-1351	61	9	disease	disease	NOUN
dti-1351	61	10	causing	cause	VERB
dti-1351	61	11	regions	region	NOUN
dti-1351	61	12	.	.	PUNCT
dti-1351	62	1	proteolytic	proteolytic	ADJ
dti-1351	62	2	cleavage	cleavage	NOUN
dti-1351	62	3	sites	site	NOUN
dti-1351	62	4	were	be	AUX
dti-1351	62	5	iden­	iden­	NOUN
dti-1351	62	6	tified	tifie	VERB
dti-1351	62	7	by	by	ADP
dti-1351	62	8	using	use	VERB
dti-1351	62	9	a	a	DET
dti-1351	62	10	web­based	web­base	VERB
dti-1351	62	11	tool	tool	NOUN
dti-1351	62	12	peptide	peptide	NOUN
dti-1351	62	13	cutter	cutter	NOUN
dti-1351	62	14	(	(	PUNCT
dti-1351	62	15	http://web	http://web	PROPN
dti-1351	62	16	.	.	PROPN
dti-1351	62	17	expasy.org/peptide_cutter/	expasy.org/peptide_cutter/	NOUN
dti-1351	62	18	)	)	PUNCT
dti-1351	62	19	,	,	PUNCT
dti-1351	62	20	which	which	PRON
dti-1351	62	21	predicts	predict	VERB
dti-1351	62	22	the	the	DET
dti-1351	62	23	proteolytic	proteolytic	ADJ
dti-1351	62	24	cleavage	cleavage	NOUN
dti-1351	62	25	sites	site	NOUN
dti-1351	62	26	and	and	CCONJ
dti-1351	62	27	sites	site	NOUN
dti-1351	62	28	cleaved	cleave	VERB
dti-1351	62	29	by	by	ADP
dti-1351	62	30	chemicals	chemical	NOUN
dti-1351	62	31	in	in	ADP
dti-1351	62	32	a	a	DET
dti-1351	62	33	given	give	VERB
dti-1351	62	34	protein	protein	NOUN
dti-1351	62	35	sequence	sequence	NOUN
dti-1351	62	36	.	.	PUNCT
dti-1351	63	1	analysis	analysis	NOUN
dti-1351	63	2	of	of	ADP
dti-1351	63	3	interacting	interact	VERB
dti-1351	63	4	networks	network	NOUN
dti-1351	63	5	.	.	PUNCT
dti-1351	64	1	alibaba23	alibaba23	NOUN
dti-1351	64	2	and	and	CCONJ
dti-1351	64	3	search	search	NOUN
dti-1351	64	4	tool	tool	NOUN
dti-1351	64	5	for	for	ADP
dti-1351	64	6	the	the	DET
dti-1351	64	7	retrieval	retrieval	NOUN
dti-1351	64	8	of	of	ADP
dti-1351	64	9	interacting	interact	VERB
dti-1351	64	10	genes	gene	NOUN
dti-1351	64	11	/	/	SYM
dti-1351	64	12	proteins	protein	NOUN
dti-1351	64	13	(	(	PUNCT
dti-1351	64	14	string)24	string)24	NOUN
dti-1351	64	15	were	be	AUX
dti-1351	64	16	used	use	VERB
dti-1351	64	17	to	to	PART
dti-1351	64	18	identify	identify	VERB
dti-1351	64	19	the	the	DET
dti-1351	64	20	networking	network	VERB
dti-1351	64	21	partners	partner	NOUN
dti-1351	64	22	of	of	ADP
dti-1351	64	23	cysteine	cysteine	NOUN
dti-1351	64	24	protease	protease	NOUN
dti-1351	64	25	yopt	yopt	NOUN
dti-1351	64	26	.	.	PUNCT
dti-1351	65	1	alibaba	alibaba	PROPN
dti-1351	65	2	can	can	AUX
dti-1351	65	3	be	be	AUX
dti-1351	65	4	used	use	VERB
dti-1351	65	5	to	to	PART
dti-1351	65	6	fit	fit	VERB
dti-1351	65	7	unstruc­	unstruc­	NOUN
dti-1351	65	8	tured	ture	VERB
dti-1351	65	9	text	text	NOUN
dti-1351	65	10	into	into	ADP
dti-1351	65	11	structured	structured	ADJ
dti-1351	65	12	data	datum	NOUN
dti-1351	65	13	records	record	NOUN
dti-1351	65	14	.	.	PUNCT
dti-1351	66	1	it	it	PRON
dti-1351	66	2	can	can	AUX
dti-1351	66	3	be	be	AUX
dti-1351	66	4	used	use	VERB
dti-1351	66	5	spe­	spe­	NOUN
dti-1351	66	6	cifically	cifically	ADV
dti-1351	66	7	for	for	ADP
dti-1351	66	8	increasing	increase	VERB
dti-1351	66	9	accuracy	accuracy	NOUN
dti-1351	66	10	and	and	CCONJ
dti-1351	66	11	efficiency	efficiency	NOUN
dti-1351	66	12	in	in	ADP
dti-1351	66	13	the	the	DET
dti-1351	66	14	process	process	NOUN
dti-1351	66	15	of	of	ADP
dti-1351	66	16	discovering	discover	VERB
dti-1351	66	17	relationships	relationship	NOUN
dti-1351	66	18	between	between	ADP
dti-1351	66	19	important	important	ADJ
dti-1351	66	20	biological	biological	ADJ
dti-1351	66	21	objects	object	NOUN
dti-1351	66	22	,	,	PUNCT
dti-1351	66	23	eg	eg	NOUN
dti-1351	66	24	,	,	PUNCT
dti-1351	66	25	protein­to­disease	protein­to­disease	PROPN
dti-1351	66	26	associations	association	NOUN
dti-1351	66	27	.	.	PUNCT
dti-1351	67	1	string	string	NOUN
dti-1351	67	2	quan­	quan­	PROPN
dti-1351	67	3	titatively	titatively	ADV
dti-1351	67	4	assimilates	assimilate	VERB
dti-1351	67	5	interaction	interaction	NOUN
dti-1351	67	6	data	datum	NOUN
dti-1351	67	7	from	from	ADP
dti-1351	67	8	these	these	DET
dti-1351	67	9	sources	source	NOUN
dti-1351	67	10	for	for	ADP
dti-1351	67	11	a	a	DET
dti-1351	67	12	http://www.la-press.com	http://www.la-press.com	X
dti-1351	67	13	http://web.expasy.org/protparam/	http://web.expasy.org/protparam/	PRON
dti-1351	67	14	http://kiharalab.org/web/pfp.php	http://kiharalab.org/web/pfp.php	NOUN
dti-1351	67	15	http://web.expasy.org/peptide_cutter/	http://web.expasy.org/peptide_cutter/	ADJ
dti-1351	67	16	http://web.expasy.org/peptide_cutter/	http://web.expasy.org/peptide_cutter/	ADJ
dti-1351	67	17	molecular	molecular	ADJ
dti-1351	67	18	characterization	characterization	NOUN
dti-1351	67	19	of	of	ADP
dti-1351	67	20	cysteine	cysteine	NOUN
dti-1351	67	21	protease	protease	NOUN
dti-1351	67	22	yopt	yopt	NOUN
dti-1351	67	23	3drug	3drug	NUM
dti-1351	67	24	target	target	NOUN
dti-1351	67	25	insights	insight	VERB
dti-1351	67	26	2014:8	2014:8	NUM
dti-1351	67	27	large	large	ADJ
dti-1351	67	28	number	number	NOUN
dti-1351	67	29	of	of	ADP
dti-1351	67	30	organisms	organism	NOUN
dti-1351	67	31	,	,	PUNCT
dti-1351	67	32	and	and	CCONJ
dti-1351	67	33	transfers	transfer	VERB
dti-1351	67	34	information	information	NOUN
dti-1351	67	35	among	among	ADP
dti-1351	67	36	these	these	DET
dti-1351	67	37	organisms	organism	NOUN
dti-1351	67	38	where	where	SCONJ
dti-1351	67	39	applicable	applicable	ADJ
dti-1351	67	40	.	.	PUNCT
dti-1351	68	1	the	the	DET
dti-1351	68	2	database	database	NOUN
dti-1351	68	3	presently	presently	ADV
dti-1351	68	4	covers	cover	VERB
dti-1351	68	5	5,214,234	5,214,234	NUM
dti-1351	68	6	proteins	protein	NOUN
dti-1351	68	7	from	from	ADP
dti-1351	68	8	1133	1133	NUM
dti-1351	68	9	organisms	organism	NOUN
dti-1351	68	10	.	.	PUNCT
dti-1351	69	1	model	model	NOUN
dti-1351	69	2	building	building	NOUN
dti-1351	69	3	and	and	CCONJ
dti-1351	69	4	refinement	refinement	NOUN
dti-1351	69	5	.	.	PUNCT
dti-1351	70	1	to	to	PART
dti-1351	70	2	predict	predict	VERB
dti-1351	70	3	the	the	DET
dti-1351	70	4	3d	3d	PROPN
dti-1351	70	5	homology	homology	NOUN
dti-1351	70	6	model	model	NOUN
dti-1351	70	7	of	of	ADP
dti-1351	70	8	cysteine	cysteine	NOUN
dti-1351	70	9	protease	protease	NOUN
dti-1351	70	10	yopt	yopt	NOUN
dti-1351	70	11	,	,	PUNCT
dti-1351	70	12	the	the	DET
dti-1351	70	13	most	most	ADV
dti-1351	70	14	popu­	popu­	NOUN
dti-1351	70	15	lar	lar	ADJ
dti-1351	70	16	online	online	ADJ
dti-1351	70	17	protein	protein	NOUN
dti-1351	70	18	fold	fold	ADJ
dti-1351	70	19	recognition	recognition	NOUN
dti-1351	70	20	server	server	NOUN
dti-1351	70	21	phyre225	phyre225	PROPN
dti-1351	70	22	(	(	PUNCT
dti-1351	70	23	protein	protein	NOUN
dti-1351	70	24	homology	homology	NOUN
dti-1351	70	25	/	/	SYM
dti-1351	70	26	analogy	analogy	NOUN
dti-1351	70	27	recognition	recognition	NOUN
dti-1351	70	28	engine	engine	NOUN
dti-1351	70	29	)	)	PUNCT
dti-1351	70	30	was	be	AUX
dti-1351	70	31	used	use	VERB
dti-1351	70	32	.	.	PUNCT
dti-1351	71	1	the	the	DET
dti-1351	71	2	input	input	NOUN
dti-1351	71	3	data	datum	NOUN
dti-1351	71	4	was	be	AUX
dti-1351	71	5	in	in	ADP
dti-1351	71	6	fasta	fasta	PROPN
dti-1351	71	7	format	format	NOUN
dti-1351	71	8	.	.	PUNCT
dti-1351	72	1	modrefiner26	modrefiner26	NOUN
dti-1351	72	2	was	be	AUX
dti-1351	72	3	used	use	VERB
dti-1351	72	4	to	to	PART
dti-1351	72	5	refine	refine	VERB
dti-1351	72	6	the	the	DET
dti-1351	72	7	predicted	predict	VERB
dti-1351	72	8	model	model	NOUN
dti-1351	72	9	.	.	PUNCT
dti-1351	73	1	evaluation	evaluation	NOUN
dti-1351	73	2	and	and	CCONJ
dti-1351	73	3	validation	validation	NOUN
dti-1351	73	4	of	of	ADP
dti-1351	73	5	model	model	NOUN
dti-1351	73	6	.	.	PUNCT
dti-1351	74	1	the	the	DET
dti-1351	74	2	accuracy	accuracy	NOUN
dti-1351	74	3	and	and	CCONJ
dti-1351	74	4	stereo	stereo	ADJ
dti-1351	74	5	chemical	chemical	NOUN
dti-1351	74	6	quality	quality	NOUN
dti-1351	74	7	of	of	ADP
dti-1351	74	8	the	the	DET
dti-1351	74	9	predicted	predict	VERB
dti-1351	74	10	model	model	NOUN
dti-1351	74	11	was	be	AUX
dti-1351	74	12	evaluated	evaluate	VERB
dti-1351	74	13	with	with	ADP
dti-1351	74	14	procheck27	procheck27	NOUN
dti-1351	74	15	by	by	ADP
dti-1351	74	16	ramachandran	ramachandran	PROPN
dti-1351	74	17	plot	plot	PROPN
dti-1351	74	18	analysis.28	analysis.28	PROPN
dti-1351	74	19	the	the	DET
dti-1351	74	20	best	good	ADJ
dti-1351	74	21	model	model	NOUN
dti-1351	74	22	was	be	AUX
dti-1351	74	23	selected	select	VERB
dti-1351	74	24	on	on	ADP
dti-1351	74	25	the	the	DET
dti-1351	74	26	basis	basis	NOUN
dti-1351	74	27	of	of	ADP
dti-1351	74	28	overall	overall	ADJ
dti-1351	74	29	g­factor	g­factor	NOUN
dti-1351	74	30	,	,	PUNCT
dti-1351	74	31	num­	num­	ADJ
dti-1351	74	32	ber	ber	NOUN
dti-1351	74	33	of	of	ADP
dti-1351	74	34	residues	residue	NOUN
dti-1351	74	35	in	in	ADP
dti-1351	74	36	core	core	NOUN
dti-1351	74	37	,	,	PUNCT
dti-1351	74	38	allowed	allow	VERB
dti-1351	74	39	,	,	PUNCT
dti-1351	74	40	additional	additional	ADJ
dti-1351	74	41	allowed	allow	VERB
dti-1351	74	42	,	,	PUNCT
dti-1351	74	43	gener­	gener­	PROPN
dti-1351	74	44	ously	ously	ADV
dti-1351	74	45	allowed	allow	VERB
dti-1351	74	46	and	and	CCONJ
dti-1351	74	47	disallowed	disallow	VERB
dti-1351	74	48	regions	region	NOUN
dti-1351	74	49	.	.	PUNCT
dti-1351	75	1	the	the	DET
dti-1351	75	2	selected	select	VERB
dti-1351	75	3	model	model	NOUN
dti-1351	75	4	was	be	AUX
dti-1351	75	5	further	far	ADV
dti-1351	75	6	analyzed	analyze	VERB
dti-1351	75	7	with	with	ADP
dti-1351	75	8	verify	verify	VERB
dti-1351	75	9	3d,29	3d,29	NUM
dti-1351	75	10	errat30	errat30	NOUN
dti-1351	75	11	and	and	CCONJ
dti-1351	75	12	3d	3d	NUM
dti-1351	75	13	match	match	NOUN
dti-1351	75	14	from	from	ADP
dti-1351	75	15	softberry	softberry	PROPN
dti-1351	75	16	(	(	PUNCT
dti-1351	75	17	http://linux1.softberry.com/	http://linux1.softberry.com/	PROPN
dti-1351	75	18	)	)	PUNCT
dti-1351	75	19	.	.	PUNCT
dti-1351	76	1	finally	finally	ADV
dti-1351	76	2	,	,	PUNCT
dti-1351	76	3	the	the	DET
dti-1351	76	4	protein	protein	NOUN
dti-1351	76	5	was	be	AUX
dti-1351	76	6	visualized	visualize	VERB
dti-1351	76	7	with	with	ADP
dti-1351	76	8	swiss­pdb	swiss­pdb	ADJ
dti-1351	76	9	viewer.31	viewer.31	ADJ
dti-1351	76	10	secondary	secondary	ADJ
dti-1351	76	11	structure	structure	NOUN
dti-1351	76	12	analysis	analysis	NOUN
dti-1351	76	13	.	.	PUNCT
dti-1351	77	1	secondary	secondary	ADJ
dti-1351	77	2	structural	structural	ADJ
dti-1351	77	3	properties	property	NOUN
dti-1351	77	4	of	of	ADP
dti-1351	77	5	the	the	DET
dti-1351	77	6	protein	protein	NOUN
dti-1351	77	7	including	include	VERB
dti-1351	77	8	alpha	alpha	NOUN
dti-1351	77	9	helix	helix	NOUN
dti-1351	77	10	,	,	PUNCT
dti-1351	77	11	310	310	NUM
dti-1351	77	12	helix	helix	NOUN
dti-1351	77	13	,	,	PUNCT
dti-1351	77	14	pi	pi	NOUN
dti-1351	77	15	helix	helix	NOUN
dti-1351	77	16	,	,	PUNCT
dti-1351	77	17	beta	beta	ADJ
dti-1351	77	18	bridge	bridge	NOUN
dti-1351	77	19	,	,	PUNCT
dti-1351	77	20	extended	extended	ADJ
dti-1351	77	21	strand	strand	NOUN
dti-1351	77	22	,	,	PUNCT
dti-1351	77	23	beta	beta	ADJ
dti-1351	77	24	turns	turn	NOUN
dti-1351	77	25	,	,	PUNCT
dti-1351	77	26	bend	bend	NOUN
dti-1351	77	27	region	region	NOUN
dti-1351	77	28	,	,	PUNCT
dti-1351	77	29	random	random	ADJ
dti-1351	77	30	coil	coil	NOUN
dti-1351	77	31	,	,	PUNCT
dti-1351	77	32	ambiguous	ambiguous	ADJ
dti-1351	77	33	states	state	NOUN
dti-1351	77	34	and	and	CCONJ
dti-1351	77	35	other	other	ADJ
dti-1351	77	36	states	state	NOUN
dti-1351	77	37	were	be	AUX
dti-1351	77	38	calcu­	calcu­	NUM
dti-1351	77	39	lated	late	VERB
dti-1351	77	40	by	by	ADP
dti-1351	77	41	the	the	DET
dti-1351	77	42	use	use	NOUN
dti-1351	77	43	of	of	ADP
dti-1351	77	44	the	the	DET
dti-1351	77	45	self­optimized	self­optimize	VERB
dti-1351	77	46	prediction	prediction	NOUN
dti-1351	77	47	method	method	NOUN
dti-1351	77	48	with	with	ADP
dti-1351	77	49	alignment	alignment	NOUN
dti-1351	77	50	(	(	PUNCT
dti-1351	77	51	sopma).32	sopma).32	VERB
dti-1351	77	52	active	active	ADJ
dti-1351	77	53	site	site	NOUN
dti-1351	77	54	analysis	analysis	NOUN
dti-1351	77	55	.	.	PUNCT
dti-1351	78	1	active	active	ADJ
dti-1351	78	2	site	site	NOUN
dti-1351	78	3	analysis	analysis	NOUN
dti-1351	78	4	was	be	AUX
dti-1351	78	5	done	do	VERB
dti-1351	78	6	with	with	ADP
dti-1351	78	7	the	the	DET
dti-1351	78	8	help	help	NOUN
dti-1351	78	9	of	of	ADP
dti-1351	78	10	computed	compute	VERB
dti-1351	78	11	atlas	atlas	PROPN
dti-1351	78	12	of	of	ADP
dti-1351	78	13	surface	surface	NOUN
dti-1351	78	14	topography	topography	NOUN
dti-1351	78	15	of	of	ADP
dti-1351	78	16	protein	protein	NOUN
dti-1351	78	17	(	(	PUNCT
dti-1351	78	18	castp).33	castp).33	NOUN
dti-1351	78	19	analysis	analysis	NOUN
dti-1351	78	20	of	of	ADP
dti-1351	78	21	active	active	ADJ
dti-1351	78	22	sites	site	NOUN
dti-1351	78	23	is	be	AUX
dti-1351	78	24	important	important	ADJ
dti-1351	78	25	for	for	ADP
dti-1351	78	26	the	the	DET
dti-1351	78	27	mode­	mode­	NOUN
dti-1351	78	28	led	lead	VERB
dti-1351	78	29	protein	protein	NOUN
dti-1351	78	30	as	as	ADP
dti-1351	78	31	a	a	DET
dti-1351	78	32	precursor	precursor	NOUN
dti-1351	78	33	to	to	PART
dti-1351	78	34	further	further	ADJ
dti-1351	78	35	work	work	VERB
dti-1351	78	36	on	on	ADP
dti-1351	78	37	its	its	PRON
dti-1351	78	38	docking	docking	NOUN
dti-1351	78	39	stud­	stud­	PROPN
dti-1351	78	40	ies	ie	NOUN
dti-1351	78	41	,	,	PUNCT
dti-1351	78	42	and	and	CCONJ
dti-1351	78	43	to	to	PART
dti-1351	78	44	shape	shape	VERB
dti-1351	78	45	the	the	DET
dti-1351	78	46	process	process	NOUN
dti-1351	78	47	of	of	ADP
dti-1351	78	48	making	make	VERB
dti-1351	78	49	a	a	DET
dti-1351	78	50	grid	grid	NOUN
dti-1351	78	51	before	before	ADP
dti-1351	78	52	docking	docking	NOUN
dti-1351	78	53	.	.	PUNCT
dti-1351	79	1	results	result	VERB
dti-1351	79	2	physicochemical	physicochemical	ADJ
dti-1351	79	3	properties	property	NOUN
dti-1351	79	4	.	.	PUNCT
dti-1351	80	1	analysis	analysis	NOUN
dti-1351	80	2	of	of	ADP
dti-1351	80	3	physicochemical	physicochemical	ADJ
dti-1351	80	4	properties	property	NOUN
dti-1351	80	5	using	use	VERB
dti-1351	80	6	protparam	protparam	PROPN
dti-1351	80	7	reveals	reveal	VERB
dti-1351	80	8	that	that	SCONJ
dti-1351	80	9	the	the	DET
dti-1351	80	10	protein	protein	NOUN
dti-1351	80	11	has	have	VERB
dti-1351	80	12	38640	38640	NUM
dti-1351	80	13	extinction	extinction	NOUN
dti-1351	80	14	coefficient	coefficient	NOUN
dti-1351	80	15	,	,	PUNCT
dti-1351	80	16	31.1	31.1	NUM
dti-1351	80	17	instability	instability	NOUN
dti-1351	80	18	index	index	NOUN
dti-1351	80	19	,	,	PUNCT
dti-1351	80	20	75.71	75.71	NUM
dti-1351	80	21	aliphatic	aliphatic	ADJ
dti-1351	80	22	index	index	NOUN
dti-1351	80	23	,	,	PUNCT
dti-1351	80	24	−0.390	−0.390	NUM
dti-1351	80	25	grand	grand	ADJ
dti-1351	80	26	average	average	NOUN
dti-1351	80	27	of	of	ADP
dti-1351	80	28	hydrophobicity	hydrophobicity	NOUN
dti-1351	80	29	with	with	ADP
dti-1351	80	30	more	more	ADV
dti-1351	80	31	positively	positively	ADV
dti-1351	80	32	charged	charge	VERB
dti-1351	80	33	residue	residue	NOUN
dti-1351	80	34	than	than	ADP
dti-1351	80	35	those	those	PRON
dti-1351	80	36	of	of	ADP
dti-1351	80	37	negatively	negatively	ADV
dti-1351	80	38	charged	charge	VERB
dti-1351	80	39	amino	amino	NOUN
dti-1351	80	40	acids	acid	NOUN
dti-1351	80	41	.	.	PUNCT
dti-1351	81	1	function	function	NOUN
dti-1351	81	2	prediction	prediction	NOUN
dti-1351	81	3	.	.	PUNCT
dti-1351	82	1	the	the	DET
dti-1351	82	2	functions	function	NOUN
dti-1351	82	3	of	of	ADP
dti-1351	82	4	protein	protein	NOUN
dti-1351	82	5	under	under	ADP
dti-1351	82	6	study	study	NOUN
dti-1351	82	7	were	be	AUX
dti-1351	82	8	predicted	predict	VERB
dti-1351	82	9	by	by	ADP
dti-1351	82	10	pfp	pfp	PROPN
dti-1351	82	11	from	from	ADP
dti-1351	82	12	kihara	kihara	PROPN
dti-1351	82	13	bioinformatics	bioinformatics	NOUN
dti-1351	82	14	laboratory	laboratory	NOUN
dti-1351	82	15	,	,	PUNCT
dti-1351	82	16	which	which	PRON
dti-1351	82	17	uses	use	VERB
dti-1351	82	18	references	reference	NOUN
dti-1351	82	19	from	from	ADP
dti-1351	82	20	gene	gene	NOUN
dti-1351	82	21	ontology	ontology	NOUN
dti-1351	82	22	.	.	PUNCT
dti-1351	83	1	these	these	PRON
dti-1351	83	2	are	be	AUX
dti-1351	83	3	shown	show	VERB
dti-1351	83	4	in	in	ADP
dti-1351	83	5	table	table	NOUN
dti-1351	83	6	1	1	NUM
dti-1351	83	7	.	.	PUNCT
dti-1351	84	1	disease	disease	NOUN
dti-1351	84	2	causing	cause	VERB
dti-1351	84	3	region	region	NOUN
dti-1351	84	4	and	and	CCONJ
dti-1351	84	5	cleavage	cleavage	NOUN
dti-1351	84	6	site	site	NOUN
dti-1351	84	7	prediction	prediction	NOUN
dti-1351	84	8	.	.	PUNCT
dti-1351	85	1	the	the	DET
dti-1351	85	2	result	result	NOUN
dti-1351	85	3	from	from	ADP
dti-1351	85	4	globplot	globplot	NOUN
dti-1351	85	5	2.3	2.3	NUM
dti-1351	85	6	was	be	AUX
dti-1351	85	7	used	use	VERB
dti-1351	85	8	to	to	PART
dti-1351	85	9	identify	identify	VERB
dti-1351	85	10	three	three	NUM
dti-1351	85	11	dis­	dis­	ADJ
dti-1351	85	12	ease	ease	NOUN
dti-1351	85	13	causing	cause	VERB
dti-1351	85	14	regions	region	NOUN
dti-1351	85	15	(	(	PUNCT
dti-1351	85	16	see	see	VERB
dti-1351	85	17	fig	fig	NOUN
dti-1351	85	18	.	.	PUNCT
dti-1351	86	1	1	1	NUM
dti-1351	86	2	)	)	PUNCT
dti-1351	86	3	.	.	PUNCT
dti-1351	87	1	protease	protease	NOUN
dti-1351	87	2	digestion	digestion	NOUN
dti-1351	87	3	is	be	AUX
dti-1351	87	4	a	a	DET
dti-1351	87	5	useful	useful	ADJ
dti-1351	87	6	table	table	NOUN
dti-1351	87	7	1	1	NUM
dti-1351	87	8	.	.	PUNCT
dti-1351	87	9	predicted	predict	VERB
dti-1351	87	10	functions	function	NOUN
dti-1351	87	11	of	of	ADP
dti-1351	87	12	cysteine	cysteine	NOUN
dti-1351	87	13	protease	protease	NOUN
dti-1351	87	14	yopt	yopt	NOUN
dti-1351	87	15	.	.	PUNCT
dti-1351	88	1	molecular	molecular	ADJ
dti-1351	88	2	function	function	NOUN
dti-1351	88	3	biological	biological	ADJ
dti-1351	88	4	process	process	NOUN
dti-1351	88	5	cellular	cellular	ADJ
dti-1351	88	6	component	component	NOUN
dti-1351	88	7	1	1	NUM
dti-1351	88	8	.	.	PUNCT
dti-1351	88	9	cysteine	cysteine	NOUN
dti-1351	88	10	type	type	NOUN
dti-1351	88	11	endopeptidase	endopeptidase	ADJ
dti-1351	88	12	activity	activity	NOUN
dti-1351	88	13	1	1	NUM
dti-1351	88	14	.	.	PUNCT
dti-1351	88	15	cellular	cellular	ADJ
dti-1351	88	16	protein	protein	NOUN
dti-1351	88	17	metabolism	metabolism	NOUN
dti-1351	88	18	1	1	NUM
dti-1351	88	19	.	.	PUNCT
dti-1351	89	1	cell	cell	NOUN
dti-1351	89	2	2	2	NUM
dti-1351	89	3	.	.	PUNCT
dti-1351	89	4	catalytic	catalytic	ADJ
dti-1351	89	5	activity	activity	NOUN
dti-1351	89	6	2	2	NUM
dti-1351	89	7	.	.	PUNCT
dti-1351	89	8	drug	drug	NOUN
dti-1351	89	9	metabolism	metabolism	NOUN
dti-1351	89	10	2	2	NUM
dti-1351	89	11	.	.	PUNCT
dti-1351	90	1	inner	inner	ADJ
dti-1351	90	2	membrane	membrane	NOUN
dti-1351	90	3	3	3	NUM
dti-1351	90	4	.	.	PUNCT
dti-1351	90	5	binding	bind	VERB
dti-1351	90	6	3	3	NUM
dti-1351	90	7	.	.	PUNCT
dti-1351	90	8	regulation	regulation	NOUN
dti-1351	90	9	of	of	ADP
dti-1351	90	10	physiological	physiological	ADJ
dti-1351	90	11	process	process	NOUN
dti-1351	90	12	3	3	NUM
dti-1351	90	13	.	.	PUNCT
dti-1351	90	14	external	external	ADJ
dti-1351	90	15	encapsulating	encapsulate	VERB
dti-1351	90	16	structure	structure	NOUN
dti-1351	90	17	4	4	NUM
dti-1351	90	18	.	.	PUNCT
dti-1351	90	19	purine	purine	NOUN
dti-1351	90	20	nucleotide	nucleotide	NOUN
dti-1351	90	21	binding	bind	VERB
dti-1351	90	22	4	4	NUM
dti-1351	90	23	.	.	NOUN
dti-1351	90	24	immune	immune	ADJ
dti-1351	90	25	cell	cell	NOUN
dti-1351	90	26	mediated	mediate	VERB
dti-1351	90	27	cytotoxicity	cytotoxicity	NOUN
dti-1351	90	28	4	4	NUM
dti-1351	90	29	.	.	PUNCT
dti-1351	90	30	intracellular	intracellular	ADJ
dti-1351	90	31	5	5	NUM
dti-1351	90	32	.	.	PUNCT
dti-1351	91	1	antigen	antigen	ADV
dti-1351	91	2	binding	bind	VERB
dti-1351	91	3	5	5	NUM
dti-1351	91	4	.	.	PUNCT
dti-1351	92	1	regulation	regulation	NOUN
dti-1351	92	2	of	of	ADP
dti-1351	92	3	type	type	NOUN
dti-1351	92	4	i	i	PRON
dti-1351	92	5	hypersensitivity	hypersensitivity	NOUN
dti-1351	92	6	5	5	NUM
dti-1351	92	7	.	.	PUNCT
dti-1351	92	8	organelle	organelle	NOUN
dti-1351	92	9	membrane	membrane	NOUN
dti-1351	92	10	curves	curve	NOUN
dti-1351	92	11	:	:	PUNCT
dti-1351	92	12	none	none	NOUN
dti-1351	92	13	1.2	1.2	NUM
dti-1351	92	14	−4.0	−4.0	NOUN
dti-1351	92	15	−9.1	−9.1	PROPN
dti-1351	92	16	−14.3	−14.3	VERB
dti-1351	92	17	−19.5	−19.5	NOUN
dti-1351	92	18	−24.6	−24.6	NOUN
dti-1351	92	19	0	0	NUM
dti-1351	92	20	20	20	NUM
dti-1351	92	21	40	40	NUM
dti-1351	92	22	60	60	NUM
dti-1351	92	23	80	80	NUM
dti-1351	92	24	100	100	NUM
dti-1351	92	25	120	120	NUM
dti-1351	92	26	140	140	NUM
dti-1351	92	27	residue	residue	NOUN
dti-1351	92	28	d	d	NOUN
dti-1351	92	29	is	be	AUX
dti-1351	92	30	o	o	PROPN
dti-1351	92	31	rd	rd	NOUN
dti-1351	93	1	er	er	INTJ
dti-1351	93	2	p	p	X
dti-1351	93	3	ro	ro	X
dti-1351	93	4	p	p	X
dti-1351	93	5	en	en	INTJ
dti-1351	93	6	si	si	X
dti-1351	94	1	ty	ty	INTJ
dti-1351	94	2	s	s	VERB
dti-1351	94	3	u	u	NOUN
dti-1351	94	4	m	m	PROPN
dti-1351	94	5	160	160	NUM
dti-1351	94	6	180	180	NUM
dti-1351	94	7	200	200	NUM
dti-1351	94	8	220	220	NUM
dti-1351	94	9	240	240	NUM
dti-1351	94	10	260	260	NUM
dti-1351	94	11	280	280	NUM
dti-1351	94	12	300	300	NUM
dti-1351	94	13	320	320	NUM
dti-1351	94	14	russell	russell	NOUN
dti-1351	94	15	linding	linding	ADJ
dti-1351	94	16	disorder	disorder	NOUN
dti-1351	94	17	globdom	globdom	ADJ
dti-1351	94	18	figure	figure	NOUN
dti-1351	94	19	1	1	NUM
dti-1351	94	20	.	.	PUNCT
dti-1351	94	21	globplot	globplot	NOUN
dti-1351	94	22	result	result	NOUN
dti-1351	94	23	shows	show	VERB
dti-1351	94	24	the	the	DET
dti-1351	94	25	disease	disease	NOUN
dti-1351	94	26	causing	cause	VERB
dti-1351	94	27	regions	region	NOUN
dti-1351	94	28	of	of	ADP
dti-1351	94	29	this	this	DET
dti-1351	94	30	protein	protein	NOUN
dti-1351	94	31	.	.	PUNCT
dti-1351	95	1	http://www.la-press.com	http://www.la-press.com	X
dti-1351	95	2	http://linux1.softberry.com/	http://linux1.softberry.com/	PROPN
dti-1351	95	3	hasan	hasan	PROPN
dti-1351	95	4	et	et	PROPN
dti-1351	95	5	al	al	PROPN
dti-1351	95	6	4	4	NUM
dti-1351	95	7	drug	drug	NOUN
dti-1351	95	8	target	target	NOUN
dti-1351	95	9	insights	insight	VERB
dti-1351	95	10	2014:8	2014:8	NUM
dti-1351	95	11	table	table	NOUN
dti-1351	95	12	2	2	NUM
dti-1351	95	13	.	.	PUNCT
dti-1351	95	14	result	result	VERB
dti-1351	95	15	from	from	ADP
dti-1351	95	16	peptide	peptide	ADJ
dti-1351	95	17	cutter	cutter	NOUN
dti-1351	95	18	.	.	PUNCT
dti-1351	96	1	name	name	NOUN
dti-1351	96	2	of	of	ADP
dti-1351	96	3	enzyme	enzyme	NOUN
dti-1351	96	4	no	no	NOUN
dti-1351	96	5	.	.	PUNCT
dti-1351	96	6	of	of	ADP
dti-1351	96	7	cleavages	cleavage	NOUN
dti-1351	96	8	positions	position	NOUN
dti-1351	96	9	of	of	ADP
dti-1351	96	10	cleavage	cleavage	NOUN
dti-1351	96	11	site	site	NOUN
dti-1351	96	12	arg	arg	PROPN
dti-1351	96	13	-	-	PUNCT
dti-1351	96	14	c	c	PROPN
dti-1351	96	15	proteinase	proteinase	NOUN
dti-1351	96	16	15	15	NUM
dti-1351	96	17	35	35	NUM
dti-1351	96	18	62	62	NUM
dti-1351	96	19	67	67	NUM
dti-1351	96	20	78	78	NUM
dti-1351	96	21	89	89	NUM
dti-1351	96	22	98	98	NUM
dti-1351	96	23	103	103	NUM
dti-1351	96	24	148	148	NUM
dti-1351	96	25	165	165	NUM
dti-1351	96	26	207	207	NUM
dti-1351	96	27	211	211	NUM
dti-1351	96	28	216	216	NUM
dti-1351	96	29	289	289	NUM
dti-1351	96	30	311	311	NUM
dti-1351	96	31	313	313	NUM
dti-1351	96	32	asp	asp	NOUN
dti-1351	96	33	-	-	PUNCT
dti-1351	96	34	n	n	NOUN
dti-1351	96	35	endopeptidase	endopeptidase	NOUN
dti-1351	96	36	16	16	NUM
dti-1351	96	37	65	65	NUM
dti-1351	96	38	71	71	NUM
dti-1351	96	39	132	132	NUM
dti-1351	96	40	157	157	NUM
dti-1351	96	41	171	171	NUM
dti-1351	96	42	182	182	NUM
dti-1351	96	43	187	187	NUM
dti-1351	96	44	189	189	NUM
dti-1351	96	45	191	191	NUM
dti-1351	96	46	196	196	NUM
dti-1351	96	47	218	218	NUM
dti-1351	96	48	229	229	NUM
dti-1351	96	49	237	237	NUM
dti-1351	96	50	273	273	NUM
dti-1351	96	51	283	283	NUM
dti-1351	96	52	317	317	NUM
dti-1351	96	53	asp	asp	NOUN
dti-1351	96	54	-	-	PUNCT
dti-1351	96	55	n	n	NOUN
dti-1351	96	56	endopeptidase	endopeptidase	NOUN
dti-1351	96	57	+	+	CCONJ
dti-1351	96	58	n	n	CCONJ
dti-1351	96	59	-	-	PUNCT
dti-1351	96	60	terminal	terminal	ADJ
dti-1351	96	61	glu	glu	NOUN
dti-1351	96	62	30	30	NUM
dti-1351	96	63	18	18	NUM
dti-1351	96	64	27	27	NUM
dti-1351	96	65	38	38	NUM
dti-1351	96	66	65	65	NUM
dti-1351	96	67	71	71	NUM
dti-1351	96	68	103	103	NUM
dti-1351	96	69	132	132	NUM
dti-1351	96	70	139	139	NUM
dti-1351	96	71	157	157	NUM
dti-1351	96	72	171	171	NUM
dti-1351	96	73	182	182	NUM
dti-1351	96	74	187	187	NUM
dti-1351	96	75	189	189	NUM
dti-1351	96	76	191	191	NUM
dti-1351	96	77	192	192	NUM
dti-1351	96	78	196	196	NUM
dti-1351	96	79	205	205	NUM
dti-1351	96	80	209	209	NUM
dti-1351	96	81	218	218	NUM
dti-1351	96	82	224	224	NUM
dti-1351	96	83	226	226	NUM
dti-1351	96	84	229	229	NUM
dti-1351	96	85	237	237	NUM
dti-1351	96	86	265	265	NUM
dti-1351	96	87	273	273	NUM
dti-1351	96	88	278	278	NUM
dti-1351	96	89	283	283	NUM
dti-1351	96	90	285	285	NUM
dti-1351	96	91	317	317	NUM
dti-1351	96	92	320	320	NUM
dti-1351	96	93	bnps	bnps	ADV
dti-1351	96	94	-	-	PUNCT
dti-1351	96	95	skatole	skatole	NOUN
dti-1351	96	96	4	4	NUM
dti-1351	96	97	146	146	NUM
dti-1351	96	98	198	198	NUM
dti-1351	96	99	291	291	NUM
dti-1351	96	100	297	297	NUM
dti-1351	96	101	cnbr	cnbr	NOUN
dti-1351	96	102	8	8	NUM
dti-1351	96	103	1	1	NUM
dti-1351	96	104	64	64	NUM
dti-1351	96	105	85	85	NUM
dti-1351	96	106	87	87	NUM
dti-1351	96	107	90	90	NUM
dti-1351	96	108	208	208	NUM
dti-1351	96	109	255	255	NUM
dti-1351	96	110	301	301	NUM
dti-1351	96	111	chymotrypsin	chymotrypsin	NOUN
dti-1351	96	112	-	-	PUNCT
dti-1351	96	113	high	high	ADJ
dti-1351	96	114	specificity	specificity	NOUN
dti-1351	96	115	33	33	NUM
dti-1351	96	116	8	8	NUM
dti-1351	96	117	15	15	NUM
dti-1351	96	118	81	81	NUM
dti-1351	96	119	83	83	NUM
dti-1351	96	120	88	88	NUM
dti-1351	96	121	93	93	NUM
dti-1351	96	122	109	109	NUM
dti-1351	96	123	115	115	NUM
dti-1351	96	124	117	117	NUM
dti-1351	96	125	124	124	NUM
dti-1351	96	126	146	146	NUM
dti-1351	96	127	157	157	NUM
dti-1351	96	128	161	161	NUM
dti-1351	96	129	169	169	NUM
dti-1351	96	130	175	175	NUM
dti-1351	96	131	198	198	NUM
dti-1351	96	132	199	199	NUM
dti-1351	96	133	244	244	NUM
dti-1351	96	134	246	246	NUM
dti-1351	96	135	263	263	NUM
dti-1351	96	136	272	272	NUM
dti-1351	96	137	273	273	NUM
dti-1351	96	138	277	277	NUM
dti-1351	96	139	280	280	NUM
dti-1351	96	140	282	282	NUM
dti-1351	96	141	288	288	NUM
dti-1351	96	142	291	291	NUM
dti-1351	96	143	292	292	NUM
dti-1351	96	144	296	296	NUM
dti-1351	96	145	297	297	NUM
dti-1351	96	146	302	302	NUM
dti-1351	96	147	312	312	NUM
dti-1351	96	148	317	317	NUM
dti-1351	96	149	chymotrypsin	chymotrypsin	NOUN
dti-1351	96	150	-	-	PUNCT
dti-1351	96	151	low	low	ADJ
dti-1351	96	152	specificity	specificity	NOUN
dti-1351	96	153	80	80	NUM
dti-1351	96	154	1	1	NUM
dti-1351	96	155	5	5	NUM
dti-1351	96	156	7	7	NUM
dti-1351	96	157	8	8	NUM
dti-1351	96	158	9	9	NUM
dti-1351	96	159	12	12	NUM
dti-1351	96	160	15	15	NUM
dti-1351	96	161	21	21	NUM
dti-1351	96	162	26	26	NUM
dti-1351	96	163	34	34	NUM
dti-1351	96	164	42	42	NUM
dti-1351	96	165	44	44	NUM
dti-1351	96	166	47	47	NUM
dti-1351	96	167	51	51	NUM
dti-1351	96	168	57	57	NUM
dti-1351	96	169	64	64	NUM
dti-1351	96	170	65	65	NUM
dti-1351	96	171	69	69	NUM
dti-1351	96	172	81	81	NUM
dti-1351	96	173	83	83	NUM
dti-1351	96	174	85	85	NUM
dti-1351	96	175	88	88	NUM
dti-1351	96	176	90	90	NUM
dti-1351	96	177	92	92	NUM
dti-1351	96	178	93	93	NUM
dti-1351	96	179	95	95	NUM
dti-1351	96	180	109	109	NUM
dti-1351	96	181	115	115	NUM
dti-1351	96	182	117	117	NUM
dti-1351	96	183	124	124	NUM
dti-1351	96	184	125	125	NUM
dti-1351	96	185	126	126	NUM
dti-1351	96	186	131	131	NUM
dti-1351	96	187	142	142	NUM
dti-1351	96	188	146	146	NUM
dti-1351	96	189	150	150	NUM
dti-1351	96	190	156	156	NUM
dti-1351	96	191	157	157	NUM
dti-1351	96	192	160	160	NUM
dti-1351	96	193	161	161	NUM
dti-1351	96	194	169	169	NUM
dti-1351	96	195	174	174	NUM
dti-1351	96	196	175	175	NUM
dti-1351	96	197	180	180	NUM
dti-1351	96	198	196	196	NUM
dti-1351	96	199	198	198	NUM
dti-1351	96	200	199	199	NUM
dti-1351	96	201	208	208	NUM
dti-1351	96	202	212	212	NUM
dti-1351	96	203	214	214	NUM
dti-1351	96	204	215	215	NUM
dti-1351	96	205	229	229	NUM
dti-1351	96	206	232	232	NUM
dti-1351	96	207	233	233	NUM
dti-1351	96	208	237	237	NUM
dti-1351	96	209	240	240	NUM
dti-1351	96	210	244	244	NUM
dti-1351	96	211	246	246	NUM
dti-1351	96	212	250	250	NUM
dti-1351	96	213	251	251	NUM
dti-1351	96	214	255	255	NUM
dti-1351	96	215	258	258	NUM
dti-1351	96	216	263	263	NUM
dti-1351	96	217	272	272	NUM
dti-1351	96	218	273	273	NUM
dti-1351	96	219	277	277	NUM
dti-1351	96	220	280	280	NUM
dti-1351	96	221	281	281	NUM
dti-1351	96	222	282	282	NUM
dti-1351	96	223	288	288	NUM
dti-1351	96	224	291	291	NUM
dti-1351	96	225	292	292	NUM
dti-1351	96	226	296	296	NUM
dti-1351	96	227	297	297	NUM
dti-1351	96	228	302	302	NUM
dti-1351	96	229	303	303	NUM
dti-1351	96	230	306	306	NUM
dti-1351	96	231	312	312	NUM
dti-1351	96	232	315	315	NUM
dti-1351	96	233	317	317	NUM
dti-1351	96	234	clostripain	clostripain	NOUN
dti-1351	96	235	15	15	NUM
dti-1351	96	236	35	35	NUM
dti-1351	96	237	62	62	NUM
dti-1351	96	238	67	67	NUM
dti-1351	96	239	78	78	NUM
dti-1351	96	240	89	89	NUM
dti-1351	96	241	98	98	NUM
dti-1351	96	242	103	103	NUM
dti-1351	96	243	148	148	NUM
dti-1351	96	244	165	165	NUM
dti-1351	96	245	207	207	NUM
dti-1351	96	246	211	211	NUM
dti-1351	96	247	216	216	NUM
dti-1351	96	248	289	289	NUM
dti-1351	96	249	311	311	NUM
dti-1351	96	250	313	313	NUM
dti-1351	96	251	formic	formic	NOUN
dti-1351	96	252	acid	acid	NOUN
dti-1351	96	253	16	16	NUM
dti-1351	96	254	66	66	NUM
dti-1351	96	255	72	72	NUM
dti-1351	96	256	133	133	NUM
dti-1351	96	257	158	158	NUM
dti-1351	96	258	172	172	NUM
dti-1351	96	259	183	183	NUM
dti-1351	96	260	188	188	NUM
dti-1351	96	261	190	190	NUM
dti-1351	96	262	192	192	NUM
dti-1351	96	263	197	197	NUM
dti-1351	96	264	219	219	NUM
dti-1351	96	265	230	230	NUM
dti-1351	96	266	238	238	NUM
dti-1351	96	267	274	274	NUM
dti-1351	96	268	284	284	NUM
dti-1351	96	269	318	318	NUM
dti-1351	96	270	glutamyl	glutamyl	NOUN
dti-1351	96	271	endopeptidase	endopeptidase	NOUN
dti-1351	96	272	14	14	NUM
dti-1351	96	273	19	19	NUM
dti-1351	96	274	28	28	NUM
dti-1351	96	275	39	39	NUM
dti-1351	96	276	104	104	NUM
dti-1351	96	277	140	140	NUM
dti-1351	96	278	193	193	NUM
dti-1351	96	279	206	206	NUM
dti-1351	96	280	210	210	NUM
dti-1351	96	281	225	225	NUM
dti-1351	96	282	227	227	NUM
dti-1351	96	283	266	266	NUM
dti-1351	96	284	279	279	NUM
dti-1351	96	285	286	286	NUM
dti-1351	96	286	321	321	NUM
dti-1351	96	287	hydroxylamine	hydroxylamine	NOUN
dti-1351	96	288	1	1	NUM
dti-1351	96	289	202	202	NUM
dti-1351	96	290	iodosobenzoic	iodosobenzoic	ADJ
dti-1351	96	291	acid	acid	NOUN
dti-1351	96	292	4	4	NUM
dti-1351	96	293	146	146	NUM
dti-1351	96	294	198	198	NUM
dti-1351	96	295	291	291	NUM
dti-1351	96	296	297	297	NUM
dti-1351	96	297	lysc	lysc	NOUN
dti-1351	96	298	23	23	NUM
dti-1351	96	299	37	37	NUM
dti-1351	96	300	49	49	NUM
dti-1351	96	301	50	50	NUM
dti-1351	96	302	56	56	NUM
dti-1351	96	303	68	68	NUM
dti-1351	96	304	74	74	NUM
dti-1351	96	305	116	116	NUM
dti-1351	96	306	121	121	NUM
dti-1351	96	307	127	127	NUM
dti-1351	96	308	130	130	NUM
dti-1351	96	309	166	166	NUM
dti-1351	96	310	168	168	NUM
dti-1351	96	311	178	178	NUM
dti-1351	96	312	186	186	NUM
dti-1351	96	313	200	200	NUM
dti-1351	96	314	201	201	NUM
dti-1351	96	315	247	247	NUM
dti-1351	96	316	248	248	NUM
dti-1351	96	317	267	267	NUM
dti-1351	96	318	285	285	NUM
dti-1351	96	319	287	287	NUM
dti-1351	96	320	290	290	NUM
dti-1351	96	321	320	320	NUM
dti-1351	96	322	lysn	lysn	ADJ
dti-1351	96	323	23	23	NUM
dti-1351	96	324	36	36	NUM
dti-1351	96	325	48	48	NUM
dti-1351	96	326	49	49	NUM
dti-1351	96	327	55	55	NUM
dti-1351	96	328	67	67	NUM
dti-1351	96	329	73	73	NUM
dti-1351	96	330	115	115	NUM
dti-1351	96	331	120	120	NUM
dti-1351	96	332	126	126	NUM
dti-1351	96	333	129	129	NUM
dti-1351	96	334	165	165	NUM
dti-1351	96	335	167	167	NUM
dti-1351	96	336	177	177	NUM
dti-1351	96	337	185	185	NUM
dti-1351	96	338	199	199	NUM
dti-1351	96	339	200	200	NUM
dti-1351	96	340	246	246	NUM
dti-1351	96	341	247	247	NUM
dti-1351	96	342	266	266	NUM
dti-1351	96	343	284	284	NUM
dti-1351	96	344	286	286	NUM
dti-1351	96	345	289	289	NUM
dti-1351	96	346	319	319	NUM
dti-1351	96	347	ntcb	ntcb	NOUN
dti-1351	97	1	[	[	X
dti-1351	97	2	2	2	NUM
dti-1351	97	3	-	-	PUNCT
dti-1351	97	4	nitro-5	nitro-5	NUM
dti-1351	97	5	thiocyanobenzoic	thiocyanobenzoic	ADJ
dti-1351	97	6	acid	acid	NOUN
dti-1351	97	7	]	]	PUNCT
dti-1351	97	8	4	4	NUM
dti-1351	97	9	138	138	NUM
dti-1351	97	10	142	142	NUM
dti-1351	97	11	184	184	NUM
dti-1351	97	12	212	212	NUM
dti-1351	97	13	pepsin	pepsin	NOUN
dti-1351	97	14	[	[	X
dti-1351	97	15	ph	ph	NOUN
dti-1351	97	16	1.3	1.3	NUM
dti-1351	97	17	]	]	SYM
dti-1351	97	18	91	91	NUM
dti-1351	97	19	8	8	NUM
dti-1351	97	20	12	12	NUM
dti-1351	97	21	14	14	NUM
dti-1351	97	22	15	15	NUM
dti-1351	97	23	20	20	NUM
dti-1351	97	24	21	21	NUM
dti-1351	97	25	25	25	NUM
dti-1351	97	26	26	26	NUM
dti-1351	97	27	41	41	NUM
dti-1351	97	28	42	42	NUM
dti-1351	97	29	47	47	NUM
dti-1351	97	30	50	50	NUM
dti-1351	97	31	65	65	NUM
dti-1351	97	32	68	68	NUM
dti-1351	97	33	81	81	NUM
dti-1351	97	34	82	82	NUM
dti-1351	97	35	83	83	NUM
dti-1351	97	36	87	87	NUM
dti-1351	97	37	88	88	NUM
dti-1351	97	38	92	92	NUM
dti-1351	97	39	93	93	NUM
dti-1351	97	40	95	95	NUM
dti-1351	97	41	108	108	NUM
dti-1351	97	42	109	109	NUM
dti-1351	97	43	114	114	NUM
dti-1351	97	44	115	115	NUM
dti-1351	97	45	116	116	NUM
dti-1351	97	46	117	117	NUM
dti-1351	97	47	124	124	NUM
dti-1351	97	48	124	124	NUM
dti-1351	97	49	125	125	NUM
dti-1351	97	50	141	141	NUM
dti-1351	97	51	142	142	NUM
dti-1351	97	52	145	145	NUM
dti-1351	97	53	146	146	NUM
dti-1351	97	54	155	155	NUM
dti-1351	97	55	156	156	NUM
dti-1351	97	56	156	156	NUM
dti-1351	97	57	157	157	NUM
dti-1351	97	58	159	159	NUM
dti-1351	97	59	160	160	NUM
dti-1351	97	60	160	160	NUM
dti-1351	97	61	161	161	NUM
dti-1351	97	62	169	169	NUM
dti-1351	97	63	173	173	NUM
dti-1351	97	64	174	174	NUM
dti-1351	97	65	174	174	NUM
dti-1351	97	66	175	175	NUM
dti-1351	97	67	179	179	NUM
dti-1351	97	68	195	195	NUM
dti-1351	97	69	196	196	NUM
dti-1351	97	70	197	197	NUM
dti-1351	97	71	198	198	NUM
dti-1351	97	72	198	198	NUM
dti-1351	97	73	199	199	NUM
dti-1351	97	74	228	228	NUM
dti-1351	97	75	229	229	NUM
dti-1351	97	76	231	231	NUM
dti-1351	97	77	232	232	NUM
dti-1351	97	78	232	232	NUM
dti-1351	97	79	233	233	NUM
dti-1351	97	80	236	236	NUM
dti-1351	97	81	237	237	NUM
dti-1351	97	82	243	243	NUM
dti-1351	97	83	244	244	NUM
dti-1351	97	84	245	245	NUM
dti-1351	97	85	246	246	NUM
dti-1351	97	86	251	251	NUM
dti-1351	97	87	262	262	NUM
dti-1351	97	88	263	263	NUM
dti-1351	97	89	271	271	NUM
dti-1351	97	90	272	272	NUM
dti-1351	97	91	272	272	NUM
dti-1351	97	92	277	277	NUM
dti-1351	97	93	279	279	NUM
dti-1351	97	94	280	280	NUM
dti-1351	97	95	281	281	NUM
dti-1351	97	96	282	282	NUM
dti-1351	97	97	288	288	NUM
dti-1351	97	98	290	290	NUM
dti-1351	97	99	295	295	NUM
dti-1351	97	100	296	296	NUM
dti-1351	97	101	296	296	NUM
dti-1351	97	102	297	297	NUM
dti-1351	97	103	301	301	NUM
dti-1351	97	104	302	302	NUM
dti-1351	97	105	304	304	NUM
dti-1351	97	106	312	312	NUM
dti-1351	97	107	314	314	NUM
dti-1351	97	108	316	316	NUM
dti-1351	97	109	317	317	NUM
dti-1351	97	110	pepsin	pepsin	NOUN
dti-1351	97	111	[	[	X
dti-1351	97	112	ph	ph	NOUN
dti-1351	97	113	.	.	PUNCT
dti-1351	98	1	2	2	NUM
dti-1351	98	2	]	]	SYM
dti-1351	98	3	64	64	NUM
dti-1351	98	4	12	12	NUM
dti-1351	98	5	20	20	NUM
dti-1351	98	6	21	21	NUM
dti-1351	98	7	25	25	NUM
dti-1351	98	8	26	26	NUM
dti-1351	98	9	41	41	NUM
dti-1351	98	10	42	42	NUM
dti-1351	98	11	47	47	NUM
dti-1351	98	12	50	50	NUM
dti-1351	98	13	65	65	NUM
dti-1351	98	14	68	68	NUM
dti-1351	98	15	81	81	NUM
dti-1351	98	16	82	82	NUM
dti-1351	98	17	83	83	NUM
dti-1351	98	18	92	92	NUM
dti-1351	98	19	93	93	NUM
dti-1351	98	20	95	95	NUM
dti-1351	98	21	114	114	NUM
dti-1351	98	22	115	115	NUM
dti-1351	98	23	116	116	NUM
dti-1351	98	24	117	117	NUM
dti-1351	98	25	124	124	NUM
dti-1351	98	26	124	124	NUM
dti-1351	98	27	125	125	NUM
dti-1351	98	28	141	141	NUM
dti-1351	98	29	142	142	NUM
dti-1351	98	30	155	155	NUM
dti-1351	98	31	156	156	NUM
dti-1351	98	32	156	156	NUM
dti-1351	98	33	157	157	NUM
dti-1351	98	34	159	159	NUM
dti-1351	98	35	160	160	NUM
dti-1351	98	36	169	169	NUM
dti-1351	98	37	173	173	NUM
dti-1351	98	38	174	174	NUM
dti-1351	98	39	179	179	NUM
dti-1351	98	40	195	195	NUM
dti-1351	98	41	196	196	NUM
dti-1351	98	42	198	198	NUM
dti-1351	98	43	199	199	NUM
dti-1351	98	44	228	228	NUM
dti-1351	98	45	229	229	NUM
dti-1351	98	46	231	231	NUM
dti-1351	98	47	232	232	NUM
dti-1351	98	48	232	232	NUM
dti-1351	98	49	233	233	NUM
dti-1351	98	50	236	236	NUM
dti-1351	98	51	237	237	NUM
dti-1351	98	52	251	251	NUM
dti-1351	98	53	271	271	NUM
dti-1351	98	54	272	272	NUM
dti-1351	98	55	272	272	NUM
dti-1351	98	56	277	277	NUM
dti-1351	98	57	279	279	NUM
dti-1351	98	58	280	280	NUM
dti-1351	98	59	281	281	NUM
dti-1351	98	60	282	282	NUM
dti-1351	98	61	288	288	NUM
dti-1351	98	62	295	295	NUM
dti-1351	98	63	296	296	NUM
dti-1351	98	64	312	312	NUM
dti-1351	98	65	314	314	NUM
dti-1351	98	66	316	316	NUM
dti-1351	98	67	317	317	NUM
dti-1351	98	68	proline	proline	NOUN
dti-1351	98	69	-	-	PUNCT
dti-1351	98	70	endopeptidase	endopeptidase	NOUN
dti-1351	98	71	1	1	NUM
dti-1351	98	72	217	217	NUM
dti-1351	98	73	proteinase	proteinase	NOUN
dti-1351	98	74	k	k	NOUN
dti-1351	98	75	148	148	NUM
dti-1351	98	76	4	4	NUM
dti-1351	98	77	8	8	NUM
dti-1351	98	78	10	10	NUM
dti-1351	98	79	12	12	NUM
dti-1351	98	80	15	15	NUM
dti-1351	98	81	17	17	NUM
dti-1351	98	82	19	19	NUM
dti-1351	98	83	21	21	NUM
dti-1351	98	84	24	24	NUM
dti-1351	98	85	25	25	NUM
dti-1351	98	86	26	26	NUM
dti-1351	98	87	27	27	NUM
dti-1351	98	88	28	28	NUM
dti-1351	98	89	30	30	NUM
dti-1351	98	90	31	31	NUM
dti-1351	98	91	33	33	NUM
dti-1351	98	92	36	36	NUM
dti-1351	98	93	38	38	NUM
dti-1351	98	94	39	39	NUM
dti-1351	98	95	40	40	NUM
dti-1351	98	96	41	41	NUM
dti-1351	98	97	42	42	NUM
dti-1351	98	98	47	47	NUM
dti-1351	98	99	51	51	NUM
dti-1351	98	100	53	53	NUM
dti-1351	98	101	54	54	NUM
dti-1351	98	102	55	55	NUM
dti-1351	98	103	65	65	NUM
dti-1351	98	104	69	69	NUM
dti-1351	98	105	70	70	NUM
dti-1351	98	106	75	75	NUM
dti-1351	98	107	81	81	NUM
dti-1351	98	108	82	82	NUM
dti-1351	98	109	83	83	NUM
dti-1351	98	110	86	86	NUM
dti-1351	98	111	88	88	NUM
dti-1351	98	112	91	91	NUM
dti-1351	98	113	93	93	NUM
dti-1351	98	114	94	94	NUM
dti-1351	98	115	95	95	NUM
dti-1351	98	116	97	97	NUM
dti-1351	98	117	99	99	NUM
dti-1351	98	118	101	101	NUM
dti-1351	98	119	102	102	NUM
dti-1351	98	120	104	104	NUM
dti-1351	98	121	106	106	NUM
dti-1351	98	122	107	107	NUM
dti-1351	98	123	109	109	NUM
dti-1351	98	124	113	113	NUM
dti-1351	98	125	115	115	NUM
dti-1351	98	126	117	117	NUM
dti-1351	98	127	118	118	NUM
dti-1351	98	128	120	120	NUM
dti-1351	98	129	123	123	NUM
dti-1351	98	130	124	124	NUM
dti-1351	98	131	125	125	NUM
dti-1351	98	132	128	128	NUM
dti-1351	98	133	129	129	NUM
dti-1351	98	134	134	134	NUM
dti-1351	98	135	135	135	NUM
dti-1351	98	136	138	138	NUM
dti-1351	98	137	140	140	NUM
dti-1351	98	138	141	141	NUM
dti-1351	98	139	142	142	NUM
dti-1351	98	140	144	144	NUM
dti-1351	98	141	146	146	NUM
dti-1351	98	142	147	147	NUM
dti-1351	98	143	151	151	NUM
dti-1351	98	144	156	156	NUM
dti-1351	98	145	157	157	NUM
dti-1351	98	146	160	160	NUM
dti-1351	98	147	161	161	NUM
dti-1351	98	148	162	162	NUM
dti-1351	98	149	169	169	NUM
dti-1351	98	150	171	171	NUM
dti-1351	98	151	173	173	NUM
dti-1351	98	152	174	174	NUM
dti-1351	98	153	175	175	NUM
dti-1351	98	154	177	177	NUM
dti-1351	98	155	180	180	NUM
dti-1351	98	156	182	182	NUM
dti-1351	98	157	187	187	NUM
dti-1351	98	158	189	189	NUM
dti-1351	98	159	193	193	NUM
dti-1351	98	160	194	194	NUM
dti-1351	98	161	195	195	NUM
dti-1351	98	162	196	196	NUM
dti-1351	98	163	198	198	NUM
dti-1351	98	164	199	199	NUM
dti-1351	98	165	204	204	NUM
dti-1351	98	166	206	206	NUM
dti-1351	98	167	209	209	NUM
dti-1351	98	168	210	210	NUM
dti-1351	98	169	214	214	NUM
dti-1351	98	170	215	215	NUM
dti-1351	98	171	218	218	NUM
dti-1351	98	172	220	220	NUM
dti-1351	98	173	221	221	NUM
dti-1351	98	174	223	223	NUM
dti-1351	98	175	224	224	NUM
dti-1351	98	176	225	225	NUM
dti-1351	98	177	227	227	NUM
dti-1351	98	178	229	229	NUM
dti-1351	98	179	232	232	NUM
dti-1351	98	180	233	233	NUM
dti-1351	98	181	235	235	NUM
dti-1351	98	182	236	236	NUM
dti-1351	98	183	237	237	NUM
dti-1351	98	184	239	239	NUM
dti-1351	98	185	242	242	NUM
dti-1351	98	186	244	244	NUM
dti-1351	98	187	246	246	NUM
dti-1351	98	188	249	249	NUM
dti-1351	98	189	251	251	NUM
dti-1351	98	190	257	257	NUM
dti-1351	98	191	259	259	NUM
dti-1351	98	192	260	260	NUM
dti-1351	98	193	261	261	NUM
dti-1351	98	194	262	262	NUM
dti-1351	98	195	263	263	NUM
dti-1351	98	196	264	264	NUM
dti-1351	98	197	266	266	NUM
dti-1351	98	198	270	270	NUM
dti-1351	98	199	271	271	NUM
dti-1351	98	200	272	272	NUM
dti-1351	98	201	273	273	NUM
dti-1351	98	202	277	277	NUM
dti-1351	98	203	279	279	NUM
dti-1351	98	204	280	280	NUM
dti-1351	98	205	282	282	NUM
dti-1351	98	206	286	286	NUM
dti-1351	98	207	288	288	NUM
dti-1351	98	208	291	291	NUM
dti-1351	98	209	292	292	NUM
dti-1351	98	210	293	293	NUM
dti-1351	98	211	296	296	NUM
dti-1351	98	212	297	297	NUM
dti-1351	98	213	302	302	NUM
dti-1351	98	214	304	304	NUM
dti-1351	98	215	306	306	NUM
dti-1351	98	216	308	308	NUM
dti-1351	98	217	312	312	NUM
dti-1351	98	218	314	314	NUM
dti-1351	98	219	315	315	NUM
dti-1351	98	220	316	316	NUM
dti-1351	98	221	317	317	NUM
dti-1351	98	222	321	321	NUM
dti-1351	98	223	322	322	NUM
dti-1351	98	224	staphylococcal	staphylococcal	ADJ
dti-1351	98	225	peptidase	peptidase	NOUN
dti-1351	99	1	i	i	PRON
dti-1351	99	2	14	14	NUM
dti-1351	99	3	19	19	NUM
dti-1351	99	4	28	28	NUM
dti-1351	99	5	39	39	NUM
dti-1351	99	6	104	104	NUM
dti-1351	99	7	140	140	NUM
dti-1351	99	8	193	193	NUM
dti-1351	99	9	206	206	NUM
dti-1351	99	10	210	210	NUM
dti-1351	99	11	225	225	NUM
dti-1351	99	12	227	227	NUM
dti-1351	99	13	266	266	NUM
dti-1351	99	14	279	279	NUM
dti-1351	99	15	286	286	NUM
dti-1351	99	16	321	321	NUM
dti-1351	99	17	thermolysin	thermolysin	NOUN
dti-1351	99	18	101	101	NUM
dti-1351	99	19	3	3	NUM
dti-1351	99	20	9	9	NUM
dti-1351	99	21	11	11	NUM
dti-1351	99	22	16	16	NUM
dti-1351	99	23	20	20	NUM
dti-1351	99	24	23	23	NUM
dti-1351	99	25	25	25	NUM
dti-1351	99	26	29	29	NUM
dti-1351	99	27	30	30	NUM
dti-1351	99	28	32	32	NUM
dti-1351	99	29	35	35	NUM
dti-1351	99	30	37	37	NUM
dti-1351	99	31	40	40	NUM
dti-1351	99	32	41	41	NUM
dti-1351	99	33	46	46	NUM
dti-1351	99	34	50	50	NUM
dti-1351	99	35	52	52	NUM
dti-1351	99	36	54	54	NUM
dti-1351	99	37	63	63	NUM
dti-1351	99	38	64	64	NUM
dti-1351	99	39	68	68	NUM
dti-1351	99	40	74	74	NUM
dti-1351	99	41	80	80	NUM
dti-1351	99	42	82	82	NUM
dti-1351	99	43	84	84	NUM
dti-1351	99	44	85	85	NUM
dti-1351	99	45	86	86	NUM
dti-1351	99	46	89	89	NUM
dti-1351	99	47	90	90	NUM
dti-1351	99	48	92	92	NUM
dti-1351	99	49	93	93	NUM
dti-1351	99	50	94	94	NUM
dti-1351	99	51	100	100	NUM
dti-1351	99	52	101	101	NUM
dti-1351	99	53	105	105	NUM
dti-1351	99	54	106	106	NUM
dti-1351	99	55	112	112	NUM
dti-1351	99	56	114	114	NUM
dti-1351	99	57	116	116	NUM
dti-1351	99	58	117	117	NUM
dti-1351	99	59	122	122	NUM
dti-1351	99	60	123	123	NUM
dti-1351	99	61	124	124	NUM
dti-1351	99	62	127	127	NUM
dti-1351	99	63	128	128	NUM
dti-1351	99	64	134	134	NUM
dti-1351	99	65	137	137	NUM
dti-1351	99	66	141	141	NUM
dti-1351	99	67	143	143	NUM
dti-1351	99	68	146	146	NUM
dti-1351	99	69	150	150	NUM
dti-1351	99	70	155	155	NUM
dti-1351	99	71	156	156	NUM
dti-1351	99	72	159	159	NUM
dti-1351	99	73	161	161	NUM
dti-1351	99	74	168	168	NUM
dti-1351	99	75	170	170	NUM
dti-1351	99	76	173	173	NUM
dti-1351	99	77	176	176	NUM
dti-1351	99	78	179	179	NUM
dti-1351	99	79	181	181	NUM
dti-1351	99	80	186	186	NUM
dti-1351	99	81	195	195	NUM
dti-1351	99	82	198	198	NUM
dti-1351	99	83	203	203	NUM
dti-1351	99	84	207	207	NUM
dti-1351	99	85	208	208	NUM
dti-1351	99	86	213	213	NUM
dti-1351	99	87	214	214	NUM
dti-1351	99	88	217	217	NUM
dti-1351	99	89	228	228	NUM
dti-1351	99	90	231	231	NUM
dti-1351	99	91	232	232	NUM
dti-1351	99	92	234	234	NUM
dti-1351	99	93	235	235	NUM
dti-1351	99	94	236	236	NUM
dti-1351	99	95	241	241	NUM
dti-1351	99	96	248	248	NUM
dti-1351	99	97	250	250	NUM
dti-1351	99	98	254	254	NUM
dti-1351	99	99	256	256	NUM
dti-1351	99	100	258	258	NUM
dti-1351	99	101	259	259	NUM
dti-1351	99	102	260	260	NUM
dti-1351	99	103	261	261	NUM
dti-1351	99	104	263	263	NUM
dti-1351	99	105	269	269	NUM
dti-1351	99	106	271	271	NUM
dti-1351	99	107	272	272	NUM
dti-1351	99	108	276	276	NUM
dti-1351	99	109	281	281	NUM
dti-1351	99	110	287	287	NUM
dti-1351	99	111	291	291	NUM
dti-1351	99	112	295	295	NUM
dti-1351	99	113	300	300	NUM
dti-1351	99	114	305	305	NUM
dti-1351	99	115	307	307	NUM
dti-1351	99	116	311	311	NUM
dti-1351	99	117	313	313	NUM
dti-1351	99	118	314	314	NUM
dti-1351	99	119	316	316	NUM
dti-1351	99	120	trypsin	trypsin	NOUN
dti-1351	99	121	37	37	NUM
dti-1351	99	122	35	35	NUM
dti-1351	99	123	37	37	NUM
dti-1351	99	124	49	49	NUM
dti-1351	99	125	50	50	NUM
dti-1351	99	126	56	56	NUM
dti-1351	99	127	62	62	NUM
dti-1351	99	128	67	67	NUM
dti-1351	99	129	68	68	NUM
dti-1351	99	130	74	74	NUM
dti-1351	99	131	78	78	NUM
dti-1351	99	132	89	89	NUM
dti-1351	99	133	98	98	NUM
dti-1351	99	134	103	103	NUM
dti-1351	99	135	116	116	NUM
dti-1351	99	136	121	121	NUM
dti-1351	99	137	127	127	NUM
dti-1351	99	138	130	130	NUM
dti-1351	99	139	148	148	NUM
dti-1351	99	140	165	165	NUM
dti-1351	99	141	166	166	NUM
dti-1351	99	142	168	168	NUM
dti-1351	99	143	178	178	NUM
dti-1351	99	144	186	186	NUM
dti-1351	99	145	200	200	NUM
dti-1351	99	146	201	201	NUM
dti-1351	99	147	207	207	NUM
dti-1351	99	148	211	211	NUM
dti-1351	99	149	247	247	NUM
dti-1351	99	150	248	248	NUM
dti-1351	99	151	267	267	NUM
dti-1351	99	152	285	285	NUM
dti-1351	99	153	287	287	NUM
dti-1351	99	154	289	289	NUM
dti-1351	99	155	290	290	NUM
dti-1351	99	156	311	311	NUM
dti-1351	99	157	313	313	NUM
dti-1351	99	158	320	320	NUM
dti-1351	99	159	process	process	NOUN
dti-1351	99	160	that	that	PRON
dti-1351	99	161	is	be	AUX
dti-1351	99	162	used	use	VERB
dti-1351	99	163	to	to	PART
dti-1351	99	164	identify	identify	VERB
dti-1351	99	165	the	the	DET
dti-1351	99	166	presence	presence	NOUN
dti-1351	99	167	of	of	ADP
dti-1351	99	168	any	any	DET
dti-1351	99	169	cutting	cut	VERB
dti-1351	99	170	site	site	NOUN
dti-1351	99	171	in	in	ADP
dti-1351	99	172	protein	protein	NOUN
dti-1351	99	173	sequence	sequence	NOUN
dti-1351	99	174	.	.	PUNCT
dti-1351	100	1	a	a	DET
dti-1351	100	2	tool	tool	NOUN
dti-1351	100	3	from	from	ADP
dti-1351	100	4	expasy	expasy	NOUN
dti-1351	100	5	was	be	AUX
dti-1351	100	6	used	use	VERB
dti-1351	100	7	here	here	ADV
dti-1351	100	8	to	to	PART
dti-1351	100	9	determine	determine	VERB
dti-1351	100	10	the	the	DET
dti-1351	100	11	proteolytic	proteolytic	ADJ
dti-1351	100	12	cleavage	cleavage	NOUN
dti-1351	100	13	site	site	NOUN
dti-1351	100	14	.	.	PUNCT
dti-1351	101	1	according	accord	VERB
dti-1351	101	2	to	to	ADP
dti-1351	101	3	results	result	NOUN
dti-1351	101	4	from	from	ADP
dti-1351	101	5	peptide	peptide	ADJ
dti-1351	101	6	cutter	cutter	NOUN
dti-1351	101	7	there	there	PRON
dti-1351	101	8	are	be	VERB
dti-1351	101	9	several	several	ADJ
dti-1351	101	10	cleavage	cleavage	NOUN
dti-1351	101	11	sites	site	NOUN
dti-1351	101	12	for	for	ADP
dti-1351	101	13	22	22	NUM
dti-1351	101	14	dif­	dif­	NOUN
dti-1351	101	15	ferent	ferent	NOUN
dti-1351	101	16	enzymes	enzyme	NOUN
dti-1351	101	17	(	(	PUNCT
dti-1351	101	18	see	see	VERB
dti-1351	101	19	table	table	NOUN
dti-1351	101	20	2	2	NUM
dti-1351	101	21	)	)	PUNCT
dti-1351	101	22	.	.	PUNCT
dti-1351	102	1	interacting	interact	VERB
dti-1351	102	2	network	network	NOUN
dti-1351	102	3	.	.	PUNCT
dti-1351	103	1	the	the	DET
dti-1351	103	2	interacting	interact	VERB
dti-1351	103	3	partners	partner	NOUN
dti-1351	103	4	of	of	ADP
dti-1351	103	5	protein	protein	NOUN
dti-1351	103	6	under	under	ADP
dti-1351	103	7	investigation	investigation	NOUN
dti-1351	103	8	were	be	AUX
dti-1351	103	9	determined	determine	VERB
dti-1351	103	10	by	by	ADP
dti-1351	103	11	string	string	NOUN
dti-1351	103	12	(	(	PUNCT
dti-1351	103	13	see	see	VERB
dti-1351	103	14	fig	fig	NOUN
dti-1351	103	15	.	.	PUNCT
dti-1351	104	1	2a	2a	NUM
dti-1351	104	2	)	)	PUNCT
dti-1351	104	3	.	.	PUNCT
dti-1351	105	1	alibaba	alibaba	PROPN
dti-1351	105	2	was	be	AUX
dti-1351	105	3	also	also	ADV
dti-1351	105	4	used	use	VERB
dti-1351	105	5	to	to	PART
dti-1351	105	6	find	find	VERB
dti-1351	105	7	the	the	DET
dti-1351	105	8	interacting	interact	VERB
dti-1351	105	9	pro­	pro­	NOUN
dti-1351	105	10	teins	tein	NOUN
dti-1351	105	11	,	,	PUNCT
dti-1351	105	12	related	related	ADJ
dti-1351	105	13	diseases	disease	NOUN
dti-1351	105	14	,	,	PUNCT
dti-1351	105	15	species	specie	NOUN
dti-1351	105	16	and	and	CCONJ
dti-1351	105	17	types	type	NOUN
dti-1351	105	18	of	of	ADP
dti-1351	105	19	cell	cell	NOUN
dti-1351	105	20	where	where	SCONJ
dti-1351	105	21	yopt	yopt	PROPN
dti-1351	105	22	was	be	AUX
dti-1351	105	23	found	find	VERB
dti-1351	105	24	(	(	PUNCT
dti-1351	105	25	see	see	VERB
dti-1351	105	26	fig	fig	NOUN
dti-1351	105	27	.	.	PUNCT
dti-1351	106	1	2b	2b	NUM
dti-1351	106	2	)	)	PUNCT
dti-1351	106	3	.	.	PUNCT
dti-1351	107	1	http://www.la-press.com	http://www.la-press.com	X
dti-1351	108	1	molecular	molecular	ADJ
dti-1351	108	2	characterization	characterization	NOUN
dti-1351	108	3	of	of	ADP
dti-1351	108	4	cysteine	cysteine	NOUN
dti-1351	108	5	protease	protease	NOUN
dti-1351	108	6	yopt	yopt	ADJ
dti-1351	108	7	5drug	5drug	NUM
dti-1351	108	8	target	target	NOUN
dti-1351	108	9	insights	insight	VERB
dti-1351	108	10	2014:8	2014:8	NUM
dti-1351	108	11	model	model	NOUN
dti-1351	108	12	building	building	NOUN
dti-1351	108	13	and	and	CCONJ
dti-1351	108	14	refining	refining	NOUN
dti-1351	108	15	.	.	PUNCT
dti-1351	109	1	three­dimensional	three­dimensional	ADJ
dti-1351	109	2	(	(	PUNCT
dti-1351	109	3	3d	3d	NUM
dti-1351	109	4	)	)	PUNCT
dti-1351	109	5	protein	protein	NOUN
dti-1351	109	6	structures	structure	NOUN
dti-1351	109	7	provide	provide	VERB
dti-1351	109	8	valuable	valuable	ADJ
dti-1351	109	9	insights	insight	NOUN
dti-1351	109	10	into	into	ADP
dti-1351	109	11	the	the	DET
dti-1351	109	12	molecu­	molecu­	NOUN
dti-1351	109	13	lar	lar	ADJ
dti-1351	109	14	basis	basis	NOUN
dti-1351	109	15	of	of	ADP
dti-1351	109	16	protein	protein	NOUN
dti-1351	109	17	function	function	NOUN
dti-1351	109	18	.	.	PUNCT
dti-1351	110	1	the	the	DET
dti-1351	110	2	3d	3d	NUM
dti-1351	110	3	structure	structure	NOUN
dti-1351	110	4	of	of	ADP
dti-1351	110	5	the	the	DET
dti-1351	110	6	protein	protein	NOUN
dti-1351	110	7	being	be	AUX
dti-1351	110	8	investigated	investigate	VERB
dti-1351	110	9	was	be	AUX
dti-1351	110	10	determined	determine	VERB
dti-1351	110	11	by	by	ADP
dti-1351	110	12	phyre	phyre	PROPN
dti-1351	110	13	2	2	NUM
dti-1351	110	14	.	.	PUNCT
dti-1351	111	1	for	for	ADP
dti-1351	111	2	further	further	ADJ
dti-1351	111	3	refinement	refinement	NOUN
dti-1351	111	4	to	to	PART
dti-1351	111	5	determine	determine	VERB
dti-1351	111	6	the	the	DET
dti-1351	111	7	high	high	ADJ
dti-1351	111	8	resolution	resolution	NOUN
dti-1351	111	9	structure	structure	NOUN
dti-1351	111	10	of	of	ADP
dti-1351	111	11	the	the	DET
dti-1351	111	12	protein	protein	NOUN
dti-1351	111	13	,	,	PUNCT
dti-1351	111	14	modrefiner	modrefiner	X
dti-1351	111	15	was	be	AUX
dti-1351	111	16	used	use	VERB
dti-1351	111	17	.	.	PUNCT
dti-1351	112	1	model	model	NOUN
dti-1351	112	2	validation	validation	NOUN
dti-1351	112	3	.	.	PUNCT
dti-1351	113	1	for	for	ADP
dti-1351	113	2	validation	validation	NOUN
dti-1351	113	3	of	of	ADP
dti-1351	113	4	the	the	DET
dti-1351	113	5	predicted	predict	VERB
dti-1351	113	6	struc­	struc­	PROPN
dti-1351	113	7	ture	ture	NOUN
dti-1351	113	8	.	.	PUNCT
dti-1351	114	1	ramachandran	ramachandran	PROPN
dti-1351	114	2	plot	plot	PROPN
dti-1351	114	3	analysis	analysis	NOUN
dti-1351	114	4	was	be	AUX
dti-1351	114	5	done	do	VERB
dti-1351	114	6	by	by	ADP
dti-1351	114	7	procheck	procheck	NOUN
dti-1351	114	8	server	server	NOUN
dti-1351	114	9	.	.	PUNCT
dti-1351	115	1	the	the	DET
dti-1351	115	2	results	result	NOUN
dti-1351	115	3	of	of	ADP
dti-1351	115	4	this	this	DET
dti-1351	115	5	analysis	analysis	NOUN
dti-1351	115	6	are	be	AUX
dti-1351	115	7	depicted	depict	VERB
dti-1351	115	8	in	in	ADP
dti-1351	115	9	figure	figure	NOUN
dti-1351	115	10	3	3	NUM
dti-1351	115	11	and	and	CCONJ
dti-1351	115	12	table	table	NOUN
dti-1351	115	13	3	3	NUM
dti-1351	115	14	.	.	PUNCT
dti-1351	116	1	the	the	DET
dti-1351	116	2	selected	select	VERB
dti-1351	116	3	model	model	NOUN
dti-1351	116	4	was	be	AUX
dti-1351	116	5	then	then	ADV
dti-1351	116	6	verified	verify	VERB
dti-1351	116	7	by	by	ADP
dti-1351	116	8	using	use	VERB
dti-1351	116	9	errat	errat	NOUN
dti-1351	116	10	,	,	PUNCT
dti-1351	116	11	verify	verify	VERB
dti-1351	116	12	3d	3d	NUM
dti-1351	116	13	,	,	PUNCT
dti-1351	116	14	and	and	CCONJ
dti-1351	116	15	3d	3d	NUM
dti-1351	116	16	match	match	NOUN
dti-1351	116	17	from	from	ADP
dti-1351	116	18	softberry	softberry	NOUN
dti-1351	116	19	.	.	PUNCT
dti-1351	117	1	validated	validate	VERB
dti-1351	117	2	3d	3d	NUM
dti-1351	117	3	structure	structure	NOUN
dti-1351	117	4	of	of	ADP
dti-1351	117	5	cysteine	cysteine	NOUN
dti-1351	117	6	protease	protease	NOUN
dti-1351	117	7	yopt	yopt	PROPN
dti-1351	117	8	was	be	AUX
dti-1351	117	9	determined	determine	VERB
dti-1351	117	10	by	by	ADP
dti-1351	117	11	swiss­pdb	swiss­pdb	ADJ
dti-1351	117	12	(	(	PUNCT
dti-1351	117	13	see	see	VERB
dti-1351	117	14	fig	fig	NOUN
dti-1351	117	15	.	.	PUNCT
dti-1351	118	1	4	4	NUM
dti-1351	118	2	)	)	PUNCT
dti-1351	118	3	.	.	PUNCT
dti-1351	119	1	secondary	secondary	ADJ
dti-1351	119	2	structure	structure	NOUN
dti-1351	119	3	analysis	analysis	NOUN
dti-1351	119	4	.	.	PUNCT
dti-1351	120	1	secondary	secondary	ADJ
dti-1351	120	2	structure	structure	NOUN
dti-1351	120	3	pre­	pre­	PROPN
dti-1351	120	4	dictions	diction	NOUN
dti-1351	120	5	are	be	AUX
dti-1351	120	6	increasingly	increasingly	ADV
dti-1351	120	7	becoming	become	VERB
dti-1351	120	8	the	the	DET
dti-1351	120	9	work	work	NOUN
dti-1351	120	10	horse	horse	NOUN
dti-1351	120	11	for	for	ADP
dti-1351	120	12	numerous	numerous	ADJ
dti-1351	120	13	methods	method	NOUN
dti-1351	120	14	aimed	aim	VERB
dti-1351	120	15	at	at	ADP
dti-1351	120	16	predicting	predict	VERB
dti-1351	120	17	protein	protein	NOUN
dti-1351	120	18	structure	structure	NOUN
dti-1351	120	19	and	and	CCONJ
dti-1351	120	20	function	function	NOUN
dti-1351	120	21	.	.	PUNCT
dti-1351	121	1	sopma	sopma	PROPN
dti-1351	121	2	was	be	AUX
dti-1351	121	3	used	use	VERB
dti-1351	121	4	to	to	PART
dti-1351	121	5	analyze	analyze	VERB
dti-1351	121	6	the	the	DET
dti-1351	121	7	secondary	secondary	ADJ
dti-1351	121	8	structure	structure	NOUN
dti-1351	121	9	.	.	PUNCT
dti-1351	122	1	the	the	DET
dti-1351	122	2	result	result	NOUN
dti-1351	122	3	was	be	AUX
dti-1351	122	4	found	find	VERB
dti-1351	122	5	by	by	ADP
dti-1351	122	6	using	use	VERB
dti-1351	122	7	standard	standard	ADJ
dti-1351	122	8	parameters	parameter	NOUN
dti-1351	122	9	,	,	PUNCT
dti-1351	122	10	given	give	VERB
dti-1351	122	11	in	in	ADP
dti-1351	122	12	table	table	NOUN
dti-1351	122	13	4	4	NUM
dti-1351	122	14	.	.	PUNCT
dti-1351	122	15	active	active	ADJ
dti-1351	122	16	site	site	NOUN
dti-1351	122	17	prediction	prediction	NOUN
dti-1351	122	18	.	.	PUNCT
dti-1351	123	1	the	the	DET
dti-1351	123	2	active	active	ADJ
dti-1351	123	3	site	site	NOUN
dti-1351	123	4	of	of	ADP
dti-1351	123	5	cysteine	cysteine	NOUN
dti-1351	123	6	protease	protease	NOUN
dti-1351	123	7	yopt	yopt	PROPN
dti-1351	123	8	was	be	AUX
dti-1351	123	9	predicted	predict	VERB
dti-1351	123	10	using	use	VERB
dti-1351	123	11	castp	castp	ADJ
dti-1351	123	12	server	server	NOUN
dti-1351	123	13	.	.	PUNCT
dti-1351	124	1	further	far	ADV
dti-1351	124	2	,	,	PUNCT
dti-1351	124	3	in	in	ADP
dti-1351	124	4	this	this	DET
dti-1351	124	5	study	study	NOUN
dti-1351	124	6	we	we	PRON
dti-1351	124	7	have	have	AUX
dti-1351	124	8	also	also	ADV
dti-1351	124	9	reported	report	VERB
dti-1351	124	10	the	the	DET
dti-1351	124	11	best	well	ADV
dti-1351	124	12	active	active	ADJ
dti-1351	124	13	site	site	NOUN
dti-1351	124	14	area	area	NOUN
dti-1351	124	15	of	of	ADP
dti-1351	124	16	the	the	DET
dti-1351	124	17	experimental	experimental	ADJ
dti-1351	124	18	enzyme	enzyme	NOUN
dti-1351	124	19	as	as	ADV
dti-1351	124	20	well	well	ADV
dti-1351	124	21	as	as	ADP
dti-1351	124	22	the	the	DET
dti-1351	124	23	number	number	NOUN
dti-1351	124	24	of	of	ADP
dti-1351	124	25	amino	amino	NOUN
dti-1351	124	26	acid	acid	NOUN
dti-1351	124	27	involved	involve	VERB
dti-1351	124	28	in	in	ADP
dti-1351	124	29	it	it	PRON
dti-1351	124	30	.	.	PUNCT
dti-1351	125	1	[	[	X
dti-1351	125	2	fig	fig	NOUN
dti-1351	125	3	.	.	PUNCT
dti-1351	126	1	5	5	NUM
dti-1351	126	2	]	]	PUNCT
dti-1351	126	3	shows	show	VERB
dti-1351	126	4	the	the	DET
dti-1351	126	5	number	number	NOUN
dti-1351	126	6	of	of	ADP
dti-1351	126	7	pockets	pocket	NOUN
dti-1351	126	8	,	,	PUNCT
dti-1351	126	9	with	with	ADP
dti-1351	126	10	their	their	PRON
dti-1351	126	11	area	area	NOUN
dti-1351	126	12	and	and	CCONJ
dti-1351	126	13	volume	volume	NOUN
dti-1351	126	14	.	.	PUNCT
dti-1351	127	1	the	the	DET
dti-1351	127	2	best	well	ADV
dti-1351	127	3	active	active	ADJ
dti-1351	127	4	site	site	NOUN
dti-1351	127	5	is	be	AUX
dti-1351	127	6	marked	mark	VERB
dti-1351	127	7	with	with	ADP
dti-1351	127	8	1677.7	1677.7	NUM
dti-1351	127	9	areas	area	NOUN
dti-1351	127	10	and	and	CCONJ
dti-1351	127	11	a	a	DET
dti-1351	127	12	volume	volume	NOUN
dti-1351	127	13	of	of	ADP
dti-1351	127	14	2009.1	2009.1	NUM
dti-1351	127	15	.	.	PUNCT
dti-1351	128	1	discussion	discussion	NOUN
dti-1351	128	2	the	the	DET
dti-1351	128	3	uniprot	uniprot	ADJ
dti-1351	128	4	knowledge	knowledge	NOUN
dti-1351	128	5	base	base	NOUN
dti-1351	128	6	[	[	X
dti-1351	128	7	uniprotkb	uniprotkb	X
dti-1351	128	8	]	]	PUNCT
dti-1351	128	9	delivers	deliver	VERB
dti-1351	128	10	a	a	DET
dti-1351	128	11	single	single	ADJ
dti-1351	128	12	,	,	PUNCT
dti-1351	128	13	centralized	centralized	ADJ
dti-1351	128	14	,	,	PUNCT
dti-1351	128	15	authoritative	authoritative	ADJ
dti-1351	128	16	resource	resource	NOUN
dti-1351	128	17	for	for	ADP
dti-1351	128	18	protein	protein	NOUN
dti-1351	128	19	sequences	sequence	NOUN
dti-1351	128	20	and	and	CCONJ
dti-1351	128	21	functional	functional	ADJ
dti-1351	128	22	information.34	information.34	NOUN
dti-1351	128	23	sequence	sequence	NOUN
dti-1351	128	24	of	of	ADP
dti-1351	128	25	cysteine	cysteine	NOUN
dti-1351	128	26	protease	protease	NOUN
dti-1351	128	27	yopt	yopt	NOUN
dti-1351	128	28	of	of	ADP
dti-1351	128	29	yersinia	yersinia	PROPN
dti-1351	128	30	pestis	pestis	PROPN
dti-1351	128	31	was	be	AUX
dti-1351	128	32	obtained	obtain	VERB
dti-1351	128	33	from	from	ADP
dti-1351	128	34	uniprotkb	uniprotkb	NOUN
dti-1351	128	35	.	.	PUNCT
dti-1351	129	1	manual	manual	ADJ
dti-1351	129	2	annotation	annotation	NOUN
dti-1351	129	3	is	be	AUX
dti-1351	129	4	one	one	NUM
dti-1351	129	5	of	of	ADP
dti-1351	129	6	the	the	DET
dti-1351	129	7	landmarks	landmark	NOUN
dti-1351	129	8	of	of	ADP
dti-1351	129	9	the	the	DET
dti-1351	129	10	swiss­prot	swiss­prot	ADJ
dti-1351	129	11	section	section	NOUN
dti-1351	129	12	of	of	ADP
dti-1351	129	13	uniprotkb	uniprotkb	NOUN
dti-1351	129	14	.	.	PUNCT
dti-1351	130	1	physicochemical	physicochemical	ADJ
dti-1351	130	2	properties	property	NOUN
dti-1351	130	3	of	of	ADP
dti-1351	130	4	protein	protein	NOUN
dti-1351	130	5	under	under	ADP
dti-1351	130	6	this	this	DET
dti-1351	130	7	study	study	NOUN
dti-1351	130	8	were	be	AUX
dti-1351	130	9	analyzed	analyze	VERB
dti-1351	130	10	through	through	ADP
dti-1351	130	11	protparam	protparam	PROPN
dti-1351	130	12	in	in	ADP
dti-1351	130	13	respect	respect	NOUN
dti-1351	130	14	of	of	ADP
dti-1351	130	15	different	different	ADJ
dti-1351	130	16	parameters	parameter	NOUN
dti-1351	130	17	.	.	PUNCT
dti-1351	131	1	according	accord	VERB
dti-1351	131	2	to	to	ADP
dti-1351	131	3	the	the	DET
dti-1351	131	4	result	result	NOUN
dti-1351	131	5	,	,	PUNCT
dti-1351	131	6	this	this	DET
dti-1351	131	7	protein	protein	NOUN
dti-1351	131	8	has	have	VERB
dti-1351	131	9	a	a	DET
dti-1351	131	10	high	high	ADJ
dti-1351	131	11	extinction	extinction	NOUN
dti-1351	131	12	coefficient	coefficient	NOUN
dti-1351	131	13	(	(	PUNCT
dti-1351	131	14	at	at	ADP
dti-1351	131	15	280	280	NUM
dti-1351	131	16	nm	nm	NOUN
dti-1351	131	17	and	and	CCONJ
dti-1351	131	18	in	in	ADP
dti-1351	131	19	water	water	NOUN
dti-1351	131	20	)	)	PUNCT
dti-1351	131	21	,	,	PUNCT
dti-1351	131	22	low	low	ADJ
dti-1351	131	23	human	human	ADJ
dti-1351	131	24	interferon	interferon	PROPN
dti-1351	131	25	-	-	PUNCT
dti-1351	131	26	al	al	PROPN
dti-1351	131	27	...	...	PUNCT
dti-1351	131	28	interleukin-1	interleukin-1	NUM
dti-1351	131	29	...	...	PUNCT
dti-1351	131	30	interleukin-18	interleukin-18	PROPN
dti-1351	131	31	dna	dna	PROPN
dti-1351	131	32	damagemapk	damagemapk	NOUN
dti-1351	131	33	kinases	kinases	PROPN
dti-1351	131	34	acetyltransfe	acetyltransfe	PROPN
dti-1351	131	35	...	...	PUNCT
dti-1351	131	36	tumor	tumor	NOUN
dti-1351	131	37	necrosi	necrosi	NOUN
dti-1351	131	38	...	...	PUNCT
dti-1351	131	39	caspase-3	caspase-3	NUM
dti-1351	131	40	caspase-12	caspase-12	NOUN
dti-1351	131	41	fusion	fusion	NOUN
dti-1351	131	42	proteins	protein	NOUN
dti-1351	131	43	avrpphb	avrpphb	NOUN
dti-1351	131	44	qlutathione	qlutathione	NOUN
dti-1351	131	45	s	s	PART
dti-1351	131	46	...	...	PUNCT
dti-1351	131	47	lac	lac	PROPN
dti-1351	131	48	icre	icre	PROPN
dti-1351	131	49	gfp	gfp	PROPN
dti-1351	131	50	pip	pip	PROPN
dti-1351	131	51	2	2	NUM
dti-1351	131	52	vscn	vscn	NOUN
dti-1351	131	53	rhoa	rhoa	PROPN
dti-1351	131	54	rho	rho	ADJ
dti-1351	131	55	rhotekin	rhotekin	ADJ
dti-1351	131	56	yope	yope	NOUN
dti-1351	131	57	ypka	ypka	PROPN
dti-1351	131	58	yoph	yoph	PROPN
dti-1351	131	59	parp	parp	PROPN
dti-1351	131	60	asc	asc	PROPN
dti-1351	131	61	yopt	yopt	PROPN
dti-1351	131	62	mapks	mapks	NOUN
dti-1351	131	63	plague	plague	NOUN
dti-1351	131	64	yersinia	yersinia	PROPN
dti-1351	131	65	pestis	pestis	PROPN
dti-1351	131	66	death	death	NOUN
dti-1351	131	67	yersinia	yersinia	PROPN
dti-1351	131	68	ente	ente	PROPN
dti-1351	131	69	...	...	PUNCT
dti-1351	131	70	yersinia	yersinia	PROPN
dti-1351	131	71	pseu	pseu	PROPN
dti-1351	131	72	...	...	PUNCT
dti-1351	132	1	bcl-2	bcl-2	VERB
dti-1351	132	2	caspase	caspase	NOUN
dti-1351	132	3	leukemia	leukemia	PROPN
dti-1351	132	4	cd3eap	cd3eap	PROPN
dti-1351	132	5	a1	a1	NOUN
dti-1351	132	6	actin	actin	NOUN
dti-1351	132	7	il6	il6	PROPN
dti-1351	132	8	yopj	yopj	NOUN
dti-1351	132	9	bacteria	bacteria	NOUN
dti-1351	132	10	murine	murine	VERB
dti-1351	132	11	nfkb1	nfkb1	X
dti-1351	133	1	b	b	X
dti-1351	133	2	a	a	DET
dti-1351	133	3	figure	figure	NOUN
dti-1351	133	4	2	2	NUM
dti-1351	133	5	.	.	NOUN
dti-1351	133	6	string	string	NOUN
dti-1351	133	7	(	(	PUNCT
dti-1351	133	8	2a	2a	NUM
dti-1351	133	9	)	)	PUNCT
dti-1351	133	10	and	and	CCONJ
dti-1351	133	11	alibaba	alibaba	PROPN
dti-1351	133	12	(	(	PUNCT
dti-1351	133	13	2b	2b	NUM
dti-1351	133	14	)	)	PUNCT
dti-1351	133	15	shows	show	VERB
dti-1351	133	16	the	the	DET
dti-1351	133	17	interacting	interact	VERB
dti-1351	133	18	networks	network	NOUN
dti-1351	133	19	of	of	ADP
dti-1351	133	20	cysteine	cysteine	NOUN
dti-1351	133	21	protease	protease	NOUN
dti-1351	133	22	yopt	yopt	NOUN
dti-1351	133	23	.	.	PUNCT
dti-1351	134	1	http://www.la-press.com	http://www.la-press.com	X
dti-1351	135	1	hasan	hasan	PROPN
dti-1351	135	2	et	et	PROPN
dti-1351	135	3	al	al	PROPN
dti-1351	135	4	6	6	NUM
dti-1351	135	5	drug	drug	NOUN
dti-1351	135	6	target	target	NOUN
dti-1351	135	7	insights	insight	VERB
dti-1351	135	8	2014:8	2014:8	NUM
dti-1351	135	9	process	process	NOUN
dti-1351	135	10	(	(	PUNCT
dti-1351	135	11	see	see	VERB
dti-1351	135	12	table	table	NOUN
dti-1351	135	13	1	1	NUM
dti-1351	135	14	)	)	PUNCT
dti-1351	135	15	.	.	PUNCT
dti-1351	136	1	aberrant	aberrant	ADJ
dti-1351	136	2	function	function	NOUN
dti-1351	136	3	of	of	ADP
dti-1351	136	4	protein	protein	NOUN
dti-1351	136	5	is	be	AUX
dti-1351	136	6	due	due	ADJ
dti-1351	136	7	to	to	ADP
dti-1351	136	8	the	the	DET
dti-1351	136	9	disordered	disordered	ADJ
dti-1351	136	10	regions	region	NOUN
dti-1351	136	11	in	in	ADP
dti-1351	136	12	it	it	PRON
dti-1351	136	13	.	.	PUNCT
dti-1351	137	1	lack	lack	NOUN
dti-1351	137	2	of	of	ADP
dti-1351	137	3	regular	regular	ADJ
dti-1351	137	4	secondary	secondary	ADJ
dti-1351	137	5	structure	structure	NOUN
dti-1351	137	6	can	can	AUX
dti-1351	137	7	be	be	AUX
dti-1351	137	8	described	describe	VERB
dti-1351	137	9	as	as	ADP
dti-1351	137	10	protein	protein	NOUN
dti-1351	137	11	disorder.38	disorder.38	PROPN
dti-1351	137	12	globplot	globplot	NOUN
dti-1351	137	13	2.3	2.3	NUM
dti-1351	137	14	was	be	AUX
dti-1351	137	15	used	use	VERB
dti-1351	137	16	to	to	PART
dti-1351	137	17	identify	identify	VERB
dti-1351	137	18	disor­	disor­	NOUN
dti-1351	137	19	dered	dere	VERB
dti-1351	137	20	region	region	NOUN
dti-1351	137	21	within	within	ADP
dti-1351	137	22	protein	protein	NOUN
dti-1351	137	23	based	base	VERB
dti-1351	137	24	on	on	ADP
dti-1351	137	25	a	a	DET
dti-1351	137	26	running	running	NOUN
dti-1351	137	27	sum	sum	NOUN
dti-1351	137	28	of	of	ADP
dti-1351	137	29	the	the	DET
dti-1351	137	30	propensity	propensity	NOUN
dti-1351	137	31	for	for	ADP
dti-1351	137	32	amino	amino	ADJ
dti-1351	137	33	acids	acid	NOUN
dti-1351	137	34	to	to	PART
dti-1351	137	35	be	be	AUX
dti-1351	137	36	in	in	ADP
dti-1351	137	37	an	an	DET
dti-1351	137	38	ordered	order	VERB
dti-1351	137	39	or	or	CCONJ
dti-1351	137	40	disordered	disordered	ADJ
dti-1351	137	41	state	state	NOUN
dti-1351	137	42	.	.	PUNCT
dti-1351	138	1	this	this	DET
dti-1351	138	2	tool	tool	NOUN
dti-1351	138	3	can	can	AUX
dti-1351	138	4	identify	identify	VERB
dti-1351	138	5	such	such	ADJ
dti-1351	138	6	regions	region	NOUN
dti-1351	138	7	by	by	ADP
dti-1351	138	8	searching	search	VERB
dti-1351	138	9	domain	domain	NOUN
dti-1351	138	10	databases	database	NOUN
dti-1351	138	11	and	and	CCONJ
dti-1351	138	12	known	know	VERB
dti-1351	138	13	disordered	disorder	VERB
dti-1351	138	14	proteins.22	proteins.22	NOUN
dti-1351	138	15	cysteine	cysteine	NOUN
dti-1351	138	16	pro­	pro­	PROPN
dti-1351	138	17	tease	tease	NOUN
dti-1351	138	18	yopt	yopt	PROPN
dti-1351	138	19	contains	contain	VERB
dti-1351	138	20	three	three	NUM
dti-1351	138	21	disease	disease	NOUN
dti-1351	138	22	causing	cause	VERB
dti-1351	138	23	regions	region	NOUN
dti-1351	138	24	in	in	ADP
dti-1351	138	25	it	it	PRON
dti-1351	138	26	from	from	ADP
dti-1351	138	27	sequence	sequence	NOUN
dti-1351	138	28	1	1	NUM
dti-1351	138	29	to	to	ADP
dti-1351	138	30	5	5	NUM
dti-1351	138	31	,	,	PUNCT
dti-1351	138	32	271	271	NUM
dti-1351	138	33	to	to	ADP
dti-1351	138	34	279	279	NUM
dti-1351	138	35	and	and	CCONJ
dti-1351	138	36	298	298	NUM
dti-1351	138	37	to	to	ADP
dti-1351	138	38	303	303	NUM
dti-1351	138	39	respectively	respectively	ADV
dti-1351	138	40	with	with	ADP
dti-1351	138	41	decreasing	decrease	VERB
dti-1351	138	42	propensity	propensity	NOUN
dti-1351	138	43	sum	sum	NOUN
dti-1351	139	1	[	[	X
dti-1351	139	2	fig	fig	NOUN
dti-1351	139	3	.	.	PUNCT
dti-1351	140	1	1	1	NUM
dti-1351	140	2	]	]	PUNCT
dti-1351	140	3	.	.	PUNCT
dti-1351	141	1	protease	protease	NOUN
dti-1351	141	2	digestion	digestion	NOUN
dti-1351	141	3	can	can	AUX
dti-1351	141	4	be	be	AUX
dti-1351	141	5	useful	useful	ADJ
dti-1351	141	6	if	if	SCONJ
dti-1351	141	7	one	one	PRON
dti-1351	141	8	wants	want	VERB
dti-1351	141	9	to	to	PART
dti-1351	141	10	carry	carry	VERB
dti-1351	141	11	out	out	ADP
dti-1351	141	12	experiments	experiment	NOUN
dti-1351	141	13	on	on	ADP
dti-1351	141	14	a	a	DET
dti-1351	141	15	portion	portion	NOUN
dti-1351	141	16	of	of	ADP
dti-1351	141	17	a	a	DET
dti-1351	141	18	protein	protein	NOUN
dti-1351	141	19	,	,	PUNCT
dti-1351	141	20	separates	separate	VERB
dti-1351	141	21	the	the	DET
dti-1351	141	22	domains	domain	NOUN
dti-1351	141	23	in	in	ADP
dti-1351	141	24	a	a	DET
dti-1351	141	25	protein	protein	NOUN
dti-1351	141	26	,	,	PUNCT
dti-1351	141	27	removes	remove	VERB
dti-1351	141	28	a	a	DET
dti-1351	141	29	tag	tag	NOUN
dti-1351	141	30	protein	protein	NOUN
dti-1351	141	31	when	when	SCONJ
dti-1351	141	32	expressing	express	VERB
dti-1351	141	33	a	a	DET
dti-1351	141	34	fusion	fusion	NOUN
dti-1351	141	35	protein	protein	NOUN
dti-1351	141	36	,	,	PUNCT
dti-1351	141	37	or	or	CCONJ
dti-1351	141	38	makes	make	VERB
dti-1351	141	39	sure	sure	ADJ
dti-1351	141	40	that	that	SCONJ
dti-1351	141	41	the	the	DET
dti-1351	141	42	protein	protein	NOUN
dti-1351	141	43	under	under	ADP
dti-1351	141	44	investigation	investigation	NOUN
dti-1351	141	45	is	be	AUX
dti-1351	141	46	not	not	PART
dti-1351	141	47	sensitive	sensitive	ADJ
dti-1351	141	48	to	to	ADP
dti-1351	141	49	endoge­	endoge­	NOUN
dti-1351	141	50	nous	nous	ADJ
dti-1351	141	51	proteases.39	proteases.39	NOUN
dti-1351	141	52	according	accord	VERB
dti-1351	141	53	to	to	ADP
dti-1351	141	54	results	result	NOUN
dti-1351	141	55	from	from	ADP
dti-1351	141	56	peptide	peptide	ADJ
dti-1351	141	57	cutter	cutter	NOUN
dti-1351	141	58	,	,	PUNCT
dti-1351	141	59	there	there	PRON
dti-1351	141	60	are	be	VERB
dti-1351	141	61	several	several	ADJ
dti-1351	141	62	cleavage	cleavage	NOUN
dti-1351	141	63	sites	site	NOUN
dti-1351	141	64	for	for	ADP
dti-1351	141	65	22	22	NUM
dti-1351	141	66	different	different	ADJ
dti-1351	141	67	enzymes	enzyme	NOUN
dti-1351	141	68	in	in	ADP
dti-1351	141	69	our	our	PRON
dti-1351	141	70	target	target	NOUN
dti-1351	141	71	and	and	CCONJ
dti-1351	141	72	most	most	ADJ
dti-1351	141	73	of	of	ADP
dti-1351	141	74	the	the	DET
dti-1351	141	75	enzymes	enzyme	NOUN
dti-1351	141	76	are	be	AUX
dti-1351	141	77	with	with	ADP
dti-1351	141	78	several	several	ADJ
dti-1351	141	79	cutting	cutting	NOUN
dti-1351	141	80	sites	site	NOUN
dti-1351	142	1	[	[	X
dti-1351	142	2	table	table	NOUN
dti-1351	142	3	2	2	NUM
dti-1351	142	4	]	]	PUNCT
dti-1351	142	5	.	.	PUNCT
dti-1351	143	1	so	so	ADV
dti-1351	143	2	,	,	PUNCT
dti-1351	143	3	for	for	ADP
dti-1351	143	4	any	any	DET
dti-1351	143	5	type	type	NOUN
dti-1351	143	6	of	of	ADP
dti-1351	143	7	alteration	alteration	NOUN
dti-1351	143	8	in	in	ADP
dti-1351	143	9	its	its	PRON
dti-1351	143	10	sequences	sequence	NOUN
dti-1351	143	11	,	,	PUNCT
dti-1351	143	12	these	these	DET
dti-1351	143	13	cleavage	cleavage	NOUN
dti-1351	143	14	sites	site	NOUN
dti-1351	143	15	are	be	AUX
dti-1351	143	16	the	the	DET
dti-1351	143	17	potential	potential	ADJ
dti-1351	143	18	target	target	NOUN
dti-1351	143	19	.	.	PUNCT
dti-1351	144	1	proper	proper	ADJ
dti-1351	144	2	functioning	functioning	NOUN
dti-1351	144	3	of	of	ADP
dti-1351	144	4	a	a	DET
dti-1351	144	5	protein	protein	NOUN
dti-1351	144	6	generally	generally	ADV
dti-1351	144	7	requires	require	VERB
dti-1351	144	8	inter­	inter­	NUM
dti-1351	144	9	action	action	NOUN
dti-1351	144	10	with	with	ADP
dti-1351	144	11	other	other	ADJ
dti-1351	144	12	proteins	protein	NOUN
dti-1351	144	13	.	.	PUNCT
dti-1351	145	1	protein	protein	NOUN
dti-1351	145	2	–	–	PUNCT
dti-1351	145	3	protein	protein	NOUN
dti-1351	145	4	interactions	interaction	NOUN
dti-1351	145	5	have	have	VERB
dti-1351	145	6	a	a	DET
dti-1351	145	7	table	table	NOUN
dti-1351	145	8	3	3	NUM
dti-1351	145	9	.	.	PUNCT
dti-1351	145	10	ramachandran	ramachandran	PROPN
dti-1351	145	11	plot	plot	PROPN
dti-1351	145	12	statistics	statistic	NOUN
dti-1351	145	13	of	of	ADP
dti-1351	145	14	cysteine	cysteine	NOUN
dti-1351	145	15	protease	protease	NOUN
dti-1351	145	16	yopt	yopt	PROPN
dti-1351	145	17	from	from	ADP
dti-1351	145	18	yersinia	yersinia	PROPN
dti-1351	145	19	pestis	pestis	PROPN
dti-1351	145	20	.	.	PUNCT
dti-1351	146	1	ramachandran	ramachandran	PROPN
dti-1351	146	2	plot	plot	PROPN
dti-1351	146	3	statistics	statistic	NOUN
dti-1351	146	4	no	no	INTJ
dti-1351	146	5	.	.	PUNCT
dti-1351	147	1	of	of	ADP
dti-1351	147	2	residue	residue	NOUN
dti-1351	147	3	%	%	NOUN
dti-1351	147	4	residues	residue	NOUN
dti-1351	147	5	in	in	ADP
dti-1351	147	6	the	the	DET
dti-1351	147	7	most	most	ADV
dti-1351	147	8	favored	favor	VERB
dti-1351	147	9	regions	region	NOUN
dti-1351	147	10	[	[	X
dti-1351	147	11	a	a	X
dti-1351	147	12	,	,	PUNCT
dti-1351	147	13	b	b	NOUN
dti-1351	147	14	,	,	PUNCT
dti-1351	147	15	l	l	NOUN
dti-1351	147	16	]	]	X
dti-1351	147	17	269	269	NUM
dti-1351	147	18	93	93	NUM
dti-1351	147	19	residues	residue	NOUN
dti-1351	147	20	in	in	ADP
dti-1351	147	21	the	the	DET
dti-1351	147	22	additional	additional	ADJ
dti-1351	147	23	allowed	allow	VERB
dti-1351	147	24	regions	region	NOUN
dti-1351	147	25	[	[	X
dti-1351	147	26	a	a	X
dti-1351	147	27	,	,	PUNCT
dti-1351	147	28	b	b	NOUN
dti-1351	147	29	,	,	PUNCT
dti-1351	147	30	l	l	NOUN
dti-1351	147	31	,	,	PUNCT
dti-1351	147	32	p	p	X
dti-1351	147	33	]	]	X
dti-1351	147	34	17	17	NUM
dti-1351	147	35	5.9	5.9	NUM
dti-1351	147	36	residues	residue	NOUN
dti-1351	147	37	in	in	ADP
dti-1351	147	38	the	the	DET
dti-1351	147	39	generously	generously	ADV
dti-1351	147	40	allowed	allow	VERB
dti-1351	147	41	regions	region	NOUN
dti-1351	147	42	[	[	X
dti-1351	147	43	a	a	X
dti-1351	147	44	,	,	PUNCT
dti-1351	147	45	b	b	NOUN
dti-1351	147	46	,	,	PUNCT
dti-1351	147	47	l	l	NOUN
dti-1351	147	48	,	,	PUNCT
dti-1351	147	49	p	p	X
dti-1351	147	50	]	]	X
dti-1351	147	51	3	3	NUM
dti-1351	147	52	1	1	NUM
dti-1351	147	53	residues	residue	NOUN
dti-1351	147	54	in	in	ADP
dti-1351	147	55	the	the	DET
dti-1351	147	56	disallowed	disallow	VERB
dti-1351	147	57	regions	region	NOUN
dti-1351	147	58	0	0	NUM
dti-1351	147	59	0	0	NUM
dti-1351	147	60	number	number	NOUN
dti-1351	147	61	of	of	ADP
dti-1351	147	62	non	non	ADJ
dti-1351	147	63	-	-	ADJ
dti-1351	147	64	glycine	glycine	ADJ
dti-1351	147	65	and	and	CCONJ
dti-1351	147	66	non	non	ADJ
dti-1351	147	67	-	-	ADJ
dti-1351	147	68	proline	proline	ADJ
dti-1351	147	69	residues	residue	NOUN
dti-1351	147	70	289	289	NUM
dti-1351	147	71	100	100	NUM
dti-1351	147	72	number	number	NOUN
dti-1351	147	73	of	of	ADP
dti-1351	147	74	end	end	NOUN
dti-1351	147	75	-	-	PUNCT
dti-1351	147	76	residues	residue	NOUN
dti-1351	147	77	[	[	X
dti-1351	147	78	excl	excl	NOUN
dti-1351	147	79	.	.	PUNCT
dti-1351	148	1	gly	gly	PROPN
dti-1351	148	2	and	and	CCONJ
dti-1351	148	3	pro	pro	ADJ
dti-1351	148	4	]	]	X
dti-1351	148	5	2	2	NUM
dti-1351	148	6	number	number	NOUN
dti-1351	148	7	of	of	ADP
dti-1351	148	8	glycine	glycine	NOUN
dti-1351	148	9	residues	residue	NOUN
dti-1351	148	10	[	[	PUNCT
dti-1351	148	11	shown	show	VERB
dti-1351	148	12	in	in	ADP
dti-1351	148	13	triangles	triangle	NOUN
dti-1351	148	14	]	]	PUNCT
dti-1351	148	15	27	27	NUM
dti-1351	148	16	number	number	NOUN
dti-1351	148	17	of	of	ADP
dti-1351	148	18	proline	proline	NOUN
dti-1351	148	19	residues	residue	NOUN
dti-1351	148	20	4	4	NUM
dti-1351	148	21	total	total	ADJ
dti-1351	148	22	number	number	NOUN
dti-1351	148	23	of	of	ADP
dti-1351	148	24	residues	residue	NOUN
dti-1351	148	25	322	322	NUM
dti-1351	148	26	table	table	NOUN
dti-1351	148	27	4	4	NUM
dti-1351	148	28	.	.	PUNCT
dti-1351	148	29	computed	compute	VERB
dti-1351	148	30	secondary	secondary	ADJ
dti-1351	148	31	structure	structure	NOUN
dti-1351	148	32	elements	element	NOUN
dti-1351	148	33	of	of	ADP
dti-1351	148	34	cysteine	cysteine	NOUN
dti-1351	148	35	protease	protease	NOUN
dti-1351	148	36	yopt	yopt	NOUN
dti-1351	148	37	of	of	ADP
dti-1351	148	38	yersinia	yersinia	PROPN
dti-1351	148	39	pestis	pestis	PROPN
dti-1351	148	40	by	by	ADP
dti-1351	148	41	sopma	sopma	PROPN
dti-1351	148	42	.	.	PUNCT
dti-1351	149	1	structure	structure	NOUN
dti-1351	149	2	no	no	PRON
dti-1351	149	3	of	of	ADP
dti-1351	149	4	residue	residue	NOUN
dti-1351	149	5	%	%	NOUN
dti-1351	149	6	alpha	alpha	NOUN
dti-1351	149	7	helix	helix	NOUN
dti-1351	149	8	[	[	X
dti-1351	149	9	hh	hh	X
dti-1351	149	10	]	]	X
dti-1351	149	11	:	:	PUNCT
dti-1351	149	12	145	145	NUM
dti-1351	149	13	45.03	45.03	NUM
dti-1351	149	14	%	%	NOUN
dti-1351	149	15	310	310	NUM
dti-1351	149	16	helix	helix	NOUN
dti-1351	149	17	[	[	X
dti-1351	149	18	gg	gg	X
dti-1351	149	19	]	]	X
dti-1351	149	20	:	:	PUNCT
dti-1351	149	21	0	0	NUM
dti-1351	149	22	0.00	0.00	NUM
dti-1351	149	23	%	%	NOUN
dti-1351	149	24	pi	pi	NOUN
dti-1351	149	25	helix	helix	NOUN
dti-1351	149	26	[	[	X
dti-1351	149	27	ii	ii	X
dti-1351	149	28	]	]	X
dti-1351	149	29	:	:	PUNCT
dti-1351	149	30	0	0	NUM
dti-1351	149	31	0.00	0.00	NUM
dti-1351	149	32	%	%	NOUN
dti-1351	149	33	beta	beta	NOUN
dti-1351	149	34	bridge	bridge	NOUN
dti-1351	149	35	[	[	X
dti-1351	149	36	bb	bb	X
dti-1351	149	37	]	]	X
dti-1351	149	38	:	:	PUNCT
dti-1351	149	39	0	0	NUM
dti-1351	149	40	0.00	0.00	NUM
dti-1351	149	41	%	%	NOUN
dti-1351	149	42	extended	extended	ADJ
dti-1351	149	43	strand	strand	NOUN
dti-1351	150	1	[	[	X
dti-1351	150	2	ee	ee	X
dti-1351	150	3	]	]	X
dti-1351	150	4	:	:	PUNCT
dti-1351	150	5	39	39	NUM
dti-1351	150	6	12.11	12.11	NUM
dti-1351	150	7	%	%	NOUN
dti-1351	150	8	beta	beta	NOUN
dti-1351	150	9	turn	turn	NOUN
dti-1351	151	1	[	[	X
dti-1351	151	2	tt	tt	X
dti-1351	151	3	]	]	X
dti-1351	151	4	:	:	PUNCT
dti-1351	151	5	30	30	NUM
dti-1351	151	6	9.32	9.32	NUM
dti-1351	151	7	%	%	NOUN
dti-1351	151	8	bend	bend	NOUN
dti-1351	151	9	region	region	NOUN
dti-1351	152	1	[	[	X
dti-1351	152	2	ss	ss	X
dti-1351	152	3	]	]	X
dti-1351	152	4	:	:	PUNCT
dti-1351	152	5	0	0	NUM
dti-1351	152	6	0.00	0.00	NUM
dti-1351	152	7	%	%	NOUN
dti-1351	152	8	random	random	ADJ
dti-1351	152	9	coil	coil	NOUN
dti-1351	153	1	[	[	X
dti-1351	153	2	cc	cc	NOUN
dti-1351	153	3	]	]	X
dti-1351	153	4	:	:	PUNCT
dti-1351	153	5	108	108	NUM
dti-1351	153	6	33.54	33.54	NUM
dti-1351	153	7	%	%	NOUN
dti-1351	153	8	ambigous	ambigous	ADJ
dti-1351	153	9	states	state	NOUN
dti-1351	153	10	[	[	X
dti-1351	153	11	?	?	X
dti-1351	153	12	]	]	X
dti-1351	153	13	:	:	PUNCT
dti-1351	153	14	0	0	NUM
dti-1351	153	15	0.00	0.00	NUM
dti-1351	153	16	%	%	NOUN
dti-1351	153	17	other	other	ADJ
dti-1351	153	18	states	state	NOUN
dti-1351	153	19	:	:	PUNCT
dti-1351	153	20	0	0	NUM
dti-1351	153	21	0.00	0.00	NUM
dti-1351	153	22	%	%	NOUN
dti-1351	153	23	−180	−180	NOUN
dti-1351	153	24	b	b	PROPN
dti-1351	154	1	a	a	DET
dti-1351	154	2	ile	ile	PROPN
dti-1351	154	3	129	129	NUM
dti-1351	154	4	his	his	PRON
dti-1351	154	5	57	57	NUM
dti-1351	154	6	asn	asn	NOUN
dti-1351	154	7	294	294	NUM
dti-1351	154	8	b	b	PROPN
dti-1351	154	9	b	b	DET
dti-1351	154	10	a	a	PRON
dti-1351	154	11	~a	~a	NUM
dti-1351	154	12	~b	~b	X
dti-1351	154	13	~b	~b	NUM
dti-1351	154	14	~p	~p	PUNCT
dti-1351	154	15	p	p	X
dti-1351	154	16	~b	~b	NUM
dti-1351	154	17	~b	~b	PUNCT
dti-1351	154	18	b	b	NUM
dti-1351	154	19	~1	~1	ADJ
dti-1351	154	20	−135	−135	NOUN
dti-1351	154	21	−90	−90	NOUN
dti-1351	154	22	−45	−45	ADV
dti-1351	154	23	0	0	NUM
dti-1351	154	24	45	45	NUM
dti-1351	154	25	90	90	NUM
dti-1351	154	26	135	135	NUM
dti-1351	154	27	180	180	NUM
dti-1351	154	28	−135	−135	NOUN
dti-1351	154	29	−90	−90	NOUN
dti-1351	154	30	−45	−45	ADV
dti-1351	154	31	0	0	NUM
dti-1351	154	32	phi	phi	NOUN
dti-1351	154	33	(	(	PUNCT
dti-1351	154	34	degrees	degree	NOUN
dti-1351	154	35	)	)	PUNCT
dti-1351	154	36	p	p	NOUN
dti-1351	154	37	si	si	X
dti-1351	154	38	(	(	PUNCT
dti-1351	154	39	d	d	PROPN
dti-1351	154	40	eg	eg	NOUN
dti-1351	154	41	re	re	NOUN
dti-1351	154	42	es	es	NOUN
dti-1351	154	43	)	)	PUNCT
dti-1351	154	44	45	45	NUM
dti-1351	154	45	90	90	NUM
dti-1351	154	46	135	135	NUM
dti-1351	154	47	180	180	NUM
dti-1351	154	48	figure	figure	NOUN
dti-1351	154	49	3	3	NUM
dti-1351	154	50	.	.	PUNCT
dti-1351	155	1	ramachandran	ramachandran	PROPN
dti-1351	155	2	plot	plot	NOUN
dti-1351	155	3	of	of	ADP
dti-1351	155	4	cysteine	cysteine	NOUN
dti-1351	155	5	protease	protease	NOUN
dti-1351	155	6	yopt	yopt	PROPN
dti-1351	155	7	from	from	ADP
dti-1351	155	8	yersinia	yersinia	PROPN
dti-1351	155	9	pestis	pestis	PROPN
dti-1351	155	10	obtained	obtain	VERB
dti-1351	155	11	through	through	ADP
dti-1351	155	12	the	the	DET
dti-1351	155	13	modeling	modeling	NOUN
dti-1351	155	14	tool	tool	NOUN
dti-1351	155	15	.	.	PUNCT
dti-1351	156	1	figure	figure	VERB
dti-1351	156	2	4	4	NUM
dti-1351	156	3	.	.	PUNCT
dti-1351	156	4	final	final	ADJ
dti-1351	156	5	model	model	NOUN
dti-1351	156	6	of	of	ADP
dti-1351	156	7	cysteine	cysteine	NOUN
dti-1351	156	8	protease	protease	NOUN
dti-1351	156	9	yopt	yopt	PROPN
dti-1351	156	10	from	from	ADP
dti-1351	156	11	yersinia	yersinia	PROPN
dti-1351	156	12	pestis	pestis	PROPN
dti-1351	156	13	.	.	PUNCT
dti-1351	157	1	instability	instability	NOUN
dti-1351	157	2	index	index	NOUN
dti-1351	157	3	,	,	PUNCT
dti-1351	157	4	high	high	ADJ
dti-1351	157	5	aliphatic	aliphatic	ADJ
dti-1351	157	6	index	index	NOUN
dti-1351	157	7	,	,	PUNCT
dti-1351	157	8	which	which	PRON
dti-1351	157	9	is	be	AUX
dti-1351	157	10	the	the	DET
dti-1351	157	11	volume	volume	NOUN
dti-1351	157	12	of	of	ADP
dti-1351	157	13	protein	protein	NOUN
dti-1351	157	14	occupied	occupy	VERB
dti-1351	157	15	by	by	ADP
dti-1351	157	16	side	side	NOUN
dti-1351	157	17	chains	chain	NOUN
dti-1351	157	18	,	,	PUNCT
dti-1351	157	19	is	be	AUX
dti-1351	157	20	a	a	DET
dti-1351	157	21	positive	positive	ADJ
dti-1351	157	22	factor	factor	NOUN
dti-1351	157	23	for	for	ADP
dti-1351	157	24	increasing	increase	VERB
dti-1351	157	25	thermo	thermo	NOUN
dti-1351	157	26	stability	stability	NOUN
dti-1351	157	27	,	,	PUNCT
dti-1351	157	28	and	and	CCONJ
dti-1351	157	29	has	have	VERB
dti-1351	157	30	negative	negative	ADJ
dti-1351	157	31	gravy	gravy	NOUN
dti-1351	157	32	with	with	ADP
dti-1351	157	33	molecular	molecular	ADJ
dti-1351	157	34	weight	weight	NOUN
dti-1351	157	35	36308.1	36308.1	NUM
dti-1351	157	36	and	and	CCONJ
dti-1351	157	37	pi	pi	PROPN
dti-1351	157	38	9.19	9.19	NUM
dti-1351	157	39	.	.	PUNCT
dti-1351	158	1	the	the	DET
dti-1351	158	2	magnitudes	magnitude	NOUN
dti-1351	158	3	of	of	ADP
dti-1351	158	4	all	all	DET
dti-1351	158	5	parameters	parameter	NOUN
dti-1351	158	6	indicate	indicate	VERB
dti-1351	158	7	the	the	DET
dti-1351	158	8	stability	stability	NOUN
dti-1351	158	9	of	of	ADP
dti-1351	158	10	the	the	DET
dti-1351	158	11	protein	protein	NOUN
dti-1351	158	12	.	.	PUNCT
dti-1351	159	1	pro­	pro­	PROPN
dti-1351	159	2	tein	tein	PROPN
dti-1351	159	3	stability	stability	NOUN
dti-1351	159	4	is	be	AUX
dti-1351	159	5	related	relate	VERB
dti-1351	159	6	to	to	ADP
dti-1351	159	7	its	its	PRON
dti-1351	159	8	function.35	function.35	NOUN
dti-1351	159	9	a	a	DET
dti-1351	159	10	major	major	ADJ
dti-1351	159	11	hurdle	hurdle	NOUN
dti-1351	159	12	to	to	ADP
dti-1351	159	13	annotating	annotate	VERB
dti-1351	159	14	function	function	NOUN
dti-1351	159	15	of	of	ADP
dti-1351	159	16	genomes	genome	NOUN
dti-1351	159	17	of	of	ADP
dti-1351	159	18	different	different	ADJ
dti-1351	159	19	organisms	organism	NOUN
dti-1351	159	20	is	be	AUX
dti-1351	159	21	a	a	DET
dti-1351	159	22	lack	lack	NOUN
dti-1351	159	23	of	of	ADP
dti-1351	159	24	coherence	coherence	NOUN
dti-1351	159	25	in	in	ADP
dti-1351	159	26	functional	functional	ADJ
dti-1351	159	27	annotation.36	annotation.36	NOUN
dti-1351	159	28	a	a	DET
dti-1351	159	29	novel	novel	ADJ
dti-1351	159	30	algo­	algo­	NOUN
dti-1351	159	31	rithm	rithm	NOUN
dti-1351	159	32	,	,	PUNCT
dti-1351	159	33	named	name	VERB
dti-1351	159	34	pfp	pfp	PROPN
dti-1351	159	35	from	from	ADP
dti-1351	159	36	kihara	kihara	PROPN
dti-1351	159	37	bioinformatics	bioinformatics	NOUN
dti-1351	159	38	laboratory	laboratory	NOUN
dti-1351	159	39	,	,	PUNCT
dti-1351	159	40	which	which	PRON
dti-1351	159	41	extends	extend	VERB
dti-1351	159	42	a	a	DET
dti-1351	159	43	psi­blast	psi­blast	NOUN
dti-1351	159	44	search	search	NOUN
dti-1351	159	45	and	and	CCONJ
dti-1351	159	46	extracts	extract	NOUN
dti-1351	159	47	and	and	CCONJ
dti-1351	159	48	scores	score	NOUN
dti-1351	159	49	go	go	VERB
dti-1351	159	50	annotations	annotation	NOUN
dti-1351	159	51	based	base	VERB
dti-1351	159	52	on	on	ADP
dti-1351	159	53	the	the	DET
dti-1351	159	54	frequency	frequency	NOUN
dti-1351	159	55	of	of	ADP
dti-1351	159	56	their	their	PRON
dti-1351	159	57	occurrence	occurrence	NOUN
dti-1351	159	58	in	in	ADP
dti-1351	159	59	retrieved	retrieve	VERB
dti-1351	159	60	sequences	sequence	NOUN
dti-1351	159	61	,	,	PUNCT
dti-1351	159	62	was	be	AUX
dti-1351	159	63	used	use	VERB
dti-1351	159	64	to	to	PART
dti-1351	159	65	predict	predict	VERB
dti-1351	159	66	the	the	DET
dti-1351	159	67	functions	function	NOUN
dti-1351	159	68	of	of	ADP
dti-1351	159	69	target	target	NOUN
dti-1351	159	70	protein.37	protein.37	PROPN
dti-1351	159	71	function	function	NOUN
dti-1351	159	72	prediction	prediction	NOUN
dti-1351	159	73	was	be	AUX
dti-1351	159	74	done	do	VERB
dti-1351	159	75	in	in	ADP
dti-1351	159	76	terms	term	NOUN
dti-1351	159	77	of	of	ADP
dti-1351	159	78	molecular	molecular	ADJ
dti-1351	159	79	function	function	NOUN
dti-1351	159	80	,	,	PUNCT
dti-1351	159	81	cellular	cellular	ADJ
dti-1351	159	82	components	component	NOUN
dti-1351	159	83	and	and	CCONJ
dti-1351	159	84	biological	biological	ADJ
dti-1351	159	85	http://www.la-press.com	http://www.la-press.com	X
dti-1351	159	86	molecular	molecular	ADJ
dti-1351	159	87	characterization	characterization	NOUN
dti-1351	159	88	of	of	ADP
dti-1351	159	89	cysteine	cysteine	NOUN
dti-1351	159	90	protease	protease	NOUN
dti-1351	160	1	yopt	yopt	VERB
dti-1351	160	2	7drug	7drug	NUM
dti-1351	160	3	target	target	NOUN
dti-1351	160	4	insights	insight	VERB
dti-1351	160	5	2014:8	2014:8	NUM
dti-1351	160	6	vital	vital	ADJ
dti-1351	160	7	role	role	NOUN
dti-1351	160	8	in	in	ADP
dti-1351	160	9	functions	function	NOUN
dti-1351	160	10	and	and	CCONJ
dti-1351	160	11	the	the	DET
dti-1351	160	12	structural	structural	ADJ
dti-1351	160	13	organization	organization	NOUN
dti-1351	160	14	of	of	ADP
dti-1351	160	15	a	a	DET
dti-1351	160	16	cell	cell	NOUN
dti-1351	160	17	.	.	PUNCT
dti-1351	161	1	detailed	detailed	ADJ
dti-1351	161	2	view	view	NOUN
dti-1351	161	3	of	of	ADP
dti-1351	161	4	these	these	DET
dti-1351	161	5	interactions	interaction	NOUN
dti-1351	161	6	helps	help	VERB
dti-1351	161	7	in	in	ADP
dti-1351	161	8	elucidation	elucidation	NOUN
dti-1351	161	9	of	of	ADP
dti-1351	161	10	cel­	cel­	ADJ
dti-1351	161	11	lular	lular	ADJ
dti-1351	161	12	activities	activity	NOUN
dti-1351	161	13	,	,	PUNCT
dti-1351	161	14	drug	drug	NOUN
dti-1351	161	15	target	target	NOUN
dti-1351	161	16	and	and	CCONJ
dti-1351	161	17	whole	whole	ADJ
dti-1351	161	18	cell	cell	NOUN
dti-1351	161	19	engineering.40	engineering.40	PROPN
dti-1351	161	20	interaction	interaction	NOUN
dti-1351	161	21	of	of	ADP
dti-1351	161	22	cysteine	cysteine	NOUN
dti-1351	161	23	protease	protease	NOUN
dti-1351	161	24	yopt	yopt	NOUN
dti-1351	161	25	with	with	ADP
dti-1351	161	26	its	its	PRON
dti-1351	161	27	part­	part­	NOUN
dti-1351	161	28	ner	ner	NOUN
dti-1351	161	29	determined	determine	VERB
dti-1351	161	30	through	through	ADP
dti-1351	161	31	string	string	NOUN
dti-1351	161	32	is	be	AUX
dti-1351	161	33	given	give	VERB
dti-1351	161	34	in	in	ADP
dti-1351	161	35	[	[	X
dti-1351	161	36	fig	fig	NOUN
dti-1351	161	37	.	.	PUNCT
dti-1351	162	1	2a	2a	NUM
dti-1351	162	2	]	]	PUNCT
dti-1351	162	3	.	.	PUNCT
dti-1351	163	1	string	string	NOUN
dti-1351	163	2	predicts	predict	NOUN
dti-1351	163	3	results	result	VERB
dti-1351	163	4	with	with	ADP
dti-1351	163	5	a	a	DET
dti-1351	163	6	confidence	confidence	NOUN
dti-1351	163	7	score	score	NOUN
dti-1351	163	8	,	,	PUNCT
dti-1351	163	9	protein	protein	NOUN
dti-1351	163	10	domains	domain	NOUN
dti-1351	163	11	and	and	CCONJ
dti-1351	163	12	3d	3d	NUM
dti-1351	163	13	structures	structure	NOUN
dti-1351	163	14	.	.	PUNCT
dti-1351	164	1	predicting	predict	VERB
dti-1351	164	2	functions	function	NOUN
dti-1351	164	3	of	of	ADP
dti-1351	164	4	inter­	inter­	NUM
dti-1351	164	5	acting	act	VERB
dti-1351	164	6	protein	protein	NOUN
dti-1351	164	7	is	be	AUX
dti-1351	164	8	also	also	ADV
dti-1351	164	9	possible	possible	ADJ
dti-1351	164	10	from	from	ADP
dti-1351	164	11	string	string	NOUN
dti-1351	164	12	that	that	PRON
dti-1351	164	13	uses	use	VERB
dti-1351	164	14	ref­	ref­	PROPN
dti-1351	164	15	erences	erence	NOUN
dti-1351	164	16	from	from	ADP
dti-1351	164	17	uniprot	uniprot	ADJ
dti-1351	164	18	.	.	PUNCT
dti-1351	165	1	network	network	NOUN
dti-1351	165	2	shows	show	VERB
dti-1351	165	3	that	that	SCONJ
dti-1351	165	4	cysteine	cysteine	NOUN
dti-1351	165	5	protease	protease	NOUN
dti-1351	165	6	yopt	yopt	PROPN
dti-1351	165	7	interacts	interact	VERB
dti-1351	165	8	with	with	ADP
dti-1351	165	9	nine	nine	NUM
dti-1351	165	10	other	other	ADJ
dti-1351	165	11	proteins	protein	NOUN
dti-1351	165	12	among	among	ADP
dti-1351	165	13	which	which	PRON
dti-1351	165	14	yscb	yscb	NOUN
dti-1351	165	15	is	be	AUX
dti-1351	165	16	a	a	DET
dti-1351	165	17	hypothetical	hypothetical	ADJ
dti-1351	165	18	protein	protein	NOUN
dti-1351	165	19	;	;	PUNCT
dti-1351	165	20	yoph	yoph	PROPN
dti-1351	165	21	and	and	CCONJ
dti-1351	165	22	ypka	ypka	NOUN
dti-1351	165	23	both	both	PRON
dti-1351	165	24	are	be	AUX
dti-1351	165	25	viru­	viru­	PROPN
dti-1351	165	26	lence	lence	NOUN
dti-1351	165	27	determinant	determinant	ADJ
dti-1351	165	28	.	.	PUNCT
dti-1351	166	1	syct	syct	PROPN
dti-1351	166	2	is	be	AUX
dti-1351	166	3	a	a	DET
dti-1351	166	4	membrane	membrane	NOUN
dti-1351	166	5	bound	bind	VERB
dti-1351	166	6	protein	protein	NOUN
dti-1351	166	7	that	that	PRON
dti-1351	166	8	plays	play	VERB
dti-1351	166	9	a	a	DET
dti-1351	166	10	role	role	NOUN
dti-1351	166	11	in	in	ADP
dti-1351	166	12	regulating	regulate	VERB
dti-1351	166	13	calcium	calcium	NOUN
dti-1351	166	14	concentration.41	concentration.41	NOUN
dti-1351	166	15	analysis	analysis	NOUN
dti-1351	166	16	of	of	ADP
dti-1351	166	17	the	the	DET
dti-1351	166	18	protein	protein	NOUN
dti-1351	166	19	with	with	ADP
dti-1351	166	20	alibaba	alibaba	PROPN
dti-1351	167	1	[	[	X
dti-1351	167	2	fig	fig	NOUN
dti-1351	167	3	.	.	PUNCT
dti-1351	168	1	2b	2b	NOUN
dti-1351	168	2	]	]	PUNCT
dti-1351	168	3	entails	entail	VERB
dti-1351	168	4	that	that	SCONJ
dti-1351	168	5	it	it	PRON
dti-1351	168	6	is	be	AUX
dti-1351	168	7	linked	link	VERB
dti-1351	168	8	with	with	ADP
dti-1351	168	9	62	62	NUM
dti-1351	168	10	proteins	protein	NOUN
dti-1351	168	11	,	,	PUNCT
dti-1351	168	12	present	present	ADJ
dti-1351	168	13	in	in	ADP
dti-1351	168	14	22	22	NUM
dti-1351	168	15	species	specie	NOUN
dti-1351	168	16	in	in	ADP
dti-1351	168	17	14	14	NUM
dti-1351	168	18	different	different	ADJ
dti-1351	168	19	cell	cell	NOUN
dti-1351	168	20	types	type	NOUN
dti-1351	168	21	and	and	CCONJ
dti-1351	168	22	causes	cause	VERB
dti-1351	168	23	7	7	NUM
dti-1351	168	24	different	different	ADJ
dti-1351	168	25	diseases	disease	NOUN
dti-1351	168	26	.	.	PUNCT
dti-1351	169	1	red	red	ADJ
dti-1351	169	2	path	path	NOUN
dti-1351	169	3	indicates	indicate	VERB
dti-1351	169	4	the	the	DET
dti-1351	169	5	direct	direct	ADJ
dti-1351	169	6	link	link	NOUN
dti-1351	169	7	of	of	ADP
dti-1351	169	8	protein	protein	NOUN
dti-1351	169	9	with	with	ADP
dti-1351	169	10	objects	object	NOUN
dti-1351	169	11	.	.	PUNCT
dti-1351	170	1	the	the	DET
dti-1351	170	2	protein	protein	NOUN
dti-1351	170	3	is	be	AUX
dti-1351	170	4	present	present	ADJ
dti-1351	170	5	in	in	ADP
dti-1351	170	6	three	three	NUM
dti-1351	170	7	species	specie	NOUN
dti-1351	170	8	of	of	ADP
dti-1351	170	9	yersinia	yersinia	NOUN
dti-1351	170	10	.	.	PUNCT
dti-1351	171	1	according	accord	VERB
dti-1351	171	2	to	to	ADP
dti-1351	171	3	network	network	NOUN
dti-1351	171	4	generated	generate	VERB
dti-1351	171	5	by	by	ADP
dti-1351	171	6	alibaba	alibaba	PROPN
dti-1351	171	7	,	,	PUNCT
dti-1351	171	8	yopt	yopt	PROPN
dti-1351	171	9	is	be	AUX
dti-1351	171	10	responsible	responsible	ADJ
dti-1351	171	11	for	for	ADP
dti-1351	171	12	plague	plague	NOUN
dti-1351	171	13	,	,	PUNCT
dti-1351	171	14	black	black	ADJ
dti-1351	171	15	death	death	NOUN
dti-1351	171	16	,	,	PUNCT
dti-1351	171	17	dna	dna	NOUN
dti-1351	171	18	damage	damage	NOUN
dti-1351	171	19	and	and	CCONJ
dti-1351	171	20	leukemia	leukemia	NOUN
dti-1351	171	21	.	.	PUNCT
dti-1351	172	1	yopt	yopt	PROPN
dti-1351	172	2	is	be	AUX
dti-1351	172	3	directly	directly	ADV
dti-1351	172	4	linked	link	VERB
dti-1351	172	5	with	with	ADP
dti-1351	172	6	actin	actin	NOUN
dti-1351	172	7	and	and	CCONJ
dti-1351	172	8	rho	rho	ADJ
dti-1351	172	9	family	family	NOUN
dti-1351	172	10	because	because	SCONJ
dti-1351	172	11	it	it	PRON
dti-1351	172	12	disrupts	disrupt	VERB
dti-1351	172	13	cytoskeleton	cytoskeleton	NOUN
dti-1351	172	14	by	by	ADP
dti-1351	172	15	cleaving	cleave	VERB
dti-1351	172	16	rho	rho	ADJ
dti-1351	172	17	gtpases	gtpase	NOUN
dti-1351	172	18	protein	protein	NOUN
dti-1351	172	19	to	to	PART
dti-1351	172	20	produce	produce	VERB
dti-1351	172	21	disorders	disorder	NOUN
dti-1351	172	22	as	as	SCONJ
dti-1351	172	23	rho	rho	ADJ
dti-1351	172	24	family	family	NOUN
dti-1351	172	25	involves	involve	VERB
dti-1351	172	26	in	in	ADP
dti-1351	172	27	organization	organization	NOUN
dti-1351	172	28	of	of	ADP
dti-1351	172	29	actin	actin	NOUN
dti-1351	172	30	filament	filament	NOUN
dti-1351	172	31	and	and	CCONJ
dti-1351	172	32	in	in	ADP
dti-1351	172	33	different	different	ADJ
dti-1351	172	34	signaling	signal	VERB
dti-1351	172	35	processes.19,20	processes.19,20	ADJ
dti-1351	172	36	3d	3d	NOUN
dti-1351	172	37	structure	structure	NOUN
dti-1351	172	38	determination	determination	NOUN
dti-1351	172	39	is	be	AUX
dti-1351	172	40	the	the	DET
dti-1351	172	41	most	most	ADV
dti-1351	172	42	important	important	ADJ
dti-1351	172	43	part	part	NOUN
dti-1351	172	44	of	of	ADP
dti-1351	172	45	proteomics	proteomic	NOUN
dti-1351	172	46	.	.	PUNCT
dti-1351	173	1	three­dimensional	three­dimensional	ADJ
dti-1351	173	2	[	[	X
dti-1351	173	3	3d	3d	NOUN
dti-1351	173	4	]	]	PUNCT
dti-1351	173	5	protein	protein	NOUN
dti-1351	173	6	structures	structure	NOUN
dti-1351	173	7	provide	provide	VERB
dti-1351	173	8	valuable	valuable	ADJ
dti-1351	173	9	insights	insight	NOUN
dti-1351	173	10	into	into	ADP
dti-1351	173	11	the	the	DET
dti-1351	173	12	molecular	molecular	ADJ
dti-1351	173	13	basis	basis	NOUN
dti-1351	173	14	of	of	ADP
dti-1351	173	15	protein	protein	NOUN
dti-1351	173	16	function	function	NOUN
dti-1351	173	17	,	,	PUNCT
dti-1351	173	18	permitting	permit	VERB
dti-1351	173	19	an	an	DET
dti-1351	173	20	effective	effective	ADJ
dti-1351	173	21	design	design	NOUN
dti-1351	173	22	of	of	ADP
dti-1351	173	23	experiments	experiment	NOUN
dti-1351	173	24	,	,	PUNCT
dti-1351	173	25	such	such	ADJ
dti-1351	173	26	as	as	ADP
dti-1351	173	27	site­directed	site­directe	VERB
dti-1351	173	28	mutagenesis	mutagenesis	NOUN
dti-1351	173	29	,	,	PUNCT
dti-1351	173	30	studies	study	NOUN
dti-1351	173	31	of	of	ADP
dti-1351	173	32	disease­associated	disease­associate	VERB
dti-1351	173	33	mutations	mutation	NOUN
dti-1351	173	34	or	or	CCONJ
dti-1351	173	35	the	the	DET
dti-1351	173	36	structure	structure	NOUN
dti-1351	173	37	based	base	VERB
dti-1351	173	38	design	design	NOUN
dti-1351	173	39	of	of	ADP
dti-1351	173	40	specific	specific	ADJ
dti-1351	173	41	inhibitors.42	inhibitors.42	NOUN
dti-1351	173	42	therefore	therefore	ADV
dti-1351	173	43	,	,	PUNCT
dti-1351	173	44	the	the	DET
dti-1351	173	45	high	high	ADJ
dti-1351	173	46	resolution	resolution	NOUN
dti-1351	173	47	3d	3d	NUM
dti-1351	173	48	structure	structure	NOUN
dti-1351	173	49	of	of	ADP
dti-1351	173	50	a	a	DET
dti-1351	173	51	protein	protein	NOUN
dti-1351	173	52	is	be	AUX
dti-1351	173	53	the	the	DET
dti-1351	173	54	key	key	NOUN
dti-1351	173	55	to	to	PART
dti-1351	173	56	understand	understand	VERB
dti-1351	173	57	and	and	CCONJ
dti-1351	173	58	manipulate	manipulate	VERB
dti-1351	173	59	of	of	ADP
dti-1351	173	60	its	its	PRON
dti-1351	173	61	biochemical	biochemical	ADJ
dti-1351	173	62	and	and	CCONJ
dti-1351	173	63	cel­	cel­	NOUN
dti-1351	173	64	lular	lular	ADJ
dti-1351	173	65	functions.43	functions.43	NOUN
dti-1351	173	66	the	the	DET
dti-1351	173	67	theoretical	theoretical	ADJ
dti-1351	173	68	structure	structure	NOUN
dti-1351	173	69	of	of	ADP
dti-1351	173	70	cysteine	cysteine	NOUN
dti-1351	173	71	protease	protease	NOUN
dti-1351	173	72	yopt	yopt	PROPN
dti-1351	173	73	from	from	ADP
dti-1351	173	74	yersinia	yersinia	PROPN
dti-1351	173	75	pestis	pestis	PROPN
dti-1351	173	76	is	be	AUX
dti-1351	173	77	generated	generate	VERB
dti-1351	173	78	using	use	VERB
dti-1351	173	79	phyre	phyre	PROPN
dti-1351	173	80	2	2	NUM
dti-1351	173	81	.	.	NOUN
dti-1351	173	82	100	100	NUM
dti-1351	173	83	%	%	NOUN
dti-1351	173	84	confidence	confidence	NOUN
dti-1351	173	85	match	match	NOUN
dti-1351	173	86	was	be	AUX
dti-1351	173	87	obtained	obtain	VERB
dti-1351	173	88	,	,	PUNCT
dti-1351	173	89	which	which	PRON
dti-1351	173	90	is	be	AUX
dti-1351	173	91	a	a	DET
dti-1351	173	92	high	high	ADJ
dti-1351	173	93	confidence	confidence	NOUN
dti-1351	173	94	match	match	NOUN
dti-1351	173	95	.	.	PUNCT
dti-1351	174	1	this	this	PRON
dti-1351	174	2	implies	imply	VERB
dti-1351	174	3	that	that	SCONJ
dti-1351	174	4	,	,	PUNCT
dti-1351	174	5	overall	overall	ADJ
dti-1351	174	6	fold	fold	NOUN
dti-1351	174	7	of	of	ADP
dti-1351	174	8	the	the	DET
dti-1351	174	9	model	model	NOUN
dti-1351	174	10	was	be	AUX
dti-1351	174	11	almost	almost	ADV
dti-1351	174	12	certainly	certainly	ADV
dti-1351	174	13	correct	correct	ADJ
dti-1351	174	14	and	and	CCONJ
dti-1351	174	15	the	the	DET
dti-1351	174	16	central	central	ADJ
dti-1351	174	17	core	core	NOUN
dti-1351	174	18	of	of	ADP
dti-1351	174	19	the	the	DET
dti-1351	174	20	model	model	NOUN
dti-1351	174	21	tends	tend	VERB
dti-1351	174	22	to	to	PART
dti-1351	174	23	be	be	AUX
dti-1351	174	24	accurate.44	accurate.44	NOUN
dti-1351	174	25	according	accord	VERB
dti-1351	174	26	to	to	ADP
dti-1351	174	27	results	result	NOUN
dti-1351	174	28	from	from	ADP
dti-1351	174	29	phyre	phyre	PROPN
dti-1351	174	30	2	2	NUM
dti-1351	174	31	,	,	PUNCT
dti-1351	174	32	the	the	DET
dti-1351	174	33	protein	protein	NOUN
dti-1351	174	34	contains	contain	VERB
dti-1351	174	35	37	37	NUM
dti-1351	174	36	%	%	NOUN
dti-1351	174	37	disorder	disorder	NOUN
dti-1351	174	38	,	,	PUNCT
dti-1351	174	39	43	43	NUM
dti-1351	174	40	%	%	NOUN
dti-1351	174	41	alpha	alpha	NOUN
dti-1351	174	42	helix	helix	NOUN
dti-1351	174	43	and	and	CCONJ
dti-1351	174	44	15	15	NUM
dti-1351	174	45	%	%	NOUN
dti-1351	174	46	beta	beta	NOUN
dti-1351	174	47	strand	strand	NOUN
dti-1351	174	48	.	.	PUNCT
dti-1351	175	1	in	in	ADP
dti-1351	175	2	protein	protein	NOUN
dti-1351	175	3	structure	structure	NOUN
dti-1351	175	4	prediction	prediction	NOUN
dti-1351	175	5	,	,	PUNCT
dti-1351	175	6	refinement	refinement	NOUN
dti-1351	175	7	for	for	ADP
dti-1351	175	8	finding	find	VERB
dti-1351	175	9	struc­	struc­	ADP
dti-1351	175	10	tures	ture	NOUN
dti-1351	175	11	that	that	PRON
dti-1351	175	12	are	be	AUX
dti-1351	175	13	close	close	ADJ
dti-1351	175	14	to	to	ADP
dti-1351	175	15	the	the	DET
dti-1351	175	16	native	native	ADJ
dti-1351	175	17	state	state	NOUN
dti-1351	175	18	is	be	AUX
dti-1351	175	19	a	a	DET
dti-1351	175	20	great	great	ADJ
dti-1351	175	21	challenge	challenge	NOUN
dti-1351	175	22	.	.	PUNCT
dti-1351	176	1	commonly	commonly	ADV
dti-1351	176	2	used	use	VERB
dti-1351	176	3	structure	structure	NOUN
dti-1351	176	4	prediction	prediction	NOUN
dti-1351	176	5	methods	method	NOUN
dti-1351	176	6	can	can	AUX
dti-1351	176	7	predict	predict	VERB
dti-1351	176	8	the	the	DET
dti-1351	176	9	correct	correct	ADJ
dti-1351	176	10	topology	topology	NOUN
dti-1351	176	11	but	but	CCONJ
dti-1351	176	12	such	such	ADJ
dti-1351	176	13	approximate	approximate	ADJ
dti-1351	176	14	models	model	NOUN
dti-1351	176	15	are	be	AUX
dti-1351	176	16	often	often	ADV
dti-1351	176	17	not	not	PART
dti-1351	176	18	with	with	SCONJ
dti-1351	176	19	resolution	resolution	NOUN
dti-1351	176	20	required	require	VERB
dti-1351	176	21	for	for	ADP
dti-1351	176	22	many	many	ADJ
dti-1351	176	23	important	important	ADJ
dti-1351	176	24	applications	application	NOUN
dti-1351	176	25	,	,	PUNCT
dti-1351	176	26	including	include	VERB
dti-1351	176	27	virtual	virtual	ADJ
dti-1351	176	28	ligand	ligand	NOUN
dti-1351	176	29	screening	screening	NOUN
dti-1351	176	30	and	and	CCONJ
dti-1351	176	31	studies	study	NOUN
dti-1351	176	32	of	of	ADP
dti-1351	176	33	reaction	reaction	NOUN
dti-1351	176	34	mech­	mech­	PROPN
dti-1351	176	35	anisms.45	anisms.45	PROPN
dti-1351	176	36	structural	structural	ADJ
dti-1351	176	37	validation	validation	NOUN
dti-1351	176	38	of	of	ADP
dti-1351	176	39	target	target	NOUN
dti-1351	176	40	model	model	NOUN
dti-1351	176	41	was	be	AUX
dti-1351	176	42	performed	perform	VERB
dti-1351	176	43	by	by	ADP
dti-1351	176	44	procheck	procheck	NOUN
dti-1351	176	45	,	,	PUNCT
dti-1351	176	46	errat	errat	NOUN
dti-1351	176	47	and	and	CCONJ
dti-1351	176	48	verify	verify	VERB
dti-1351	176	49	3d	3d	NUM
dti-1351	176	50	.	.	PUNCT
dti-1351	177	1	procheck	procheck	PROPN
dti-1351	177	2	gen­	gen­	PROPN
dti-1351	177	3	erated	erate	VERB
dti-1351	177	4	ramachandran	ramachandran	PROPN
dti-1351	177	5	plot	plot	NOUN
dti-1351	177	6	shows	show	VERB
dti-1351	177	7	the	the	DET
dti-1351	177	8	distribution	distribution	NOUN
dti-1351	177	9	of	of	ADP
dti-1351	177	10	φ	φ	PROPN
dti-1351	177	11	and	and	CCONJ
dti-1351	177	12	ψ	ψ	PROPN
dti-1351	177	13	angle	angle	NOUN
dti-1351	177	14	in	in	ADP
dti-1351	177	15	the	the	DET
dti-1351	177	16	model	model	NOUN
dti-1351	178	1	[	[	X
dti-1351	178	2	fig	fig	NOUN
dti-1351	178	3	.	.	PUNCT
dti-1351	179	1	3	3	NUM
dti-1351	179	2	]	]	PUNCT
dti-1351	179	3	.	.	PUNCT
dti-1351	180	1	according	accord	VERB
dti-1351	180	2	to	to	ADP
dti-1351	180	3	plot	plot	NOUN
dti-1351	180	4	statistics	statistic	NOUN
dti-1351	180	5	,	,	PUNCT
dti-1351	180	6	93.0	93.0	NUM
dti-1351	180	7	%	%	NOUN
dti-1351	180	8	of	of	ADP
dti-1351	180	9	the	the	DET
dti-1351	180	10	residues	residue	NOUN
dti-1351	180	11	are	be	AUX
dti-1351	180	12	located	locate	VERB
dti-1351	180	13	in	in	ADP
dti-1351	180	14	the	the	DET
dti-1351	180	15	most	most	ADV
dti-1351	180	16	favored	favor	VERB
dti-1351	180	17	region	region	NOUN
dti-1351	180	18	,	,	PUNCT
dti-1351	180	19	5.9	5.9	NUM
dti-1351	180	20	%	%	NOUN
dti-1351	180	21	in	in	ADP
dti-1351	180	22	additional	additional	ADJ
dti-1351	180	23	region	region	NOUN
dti-1351	180	24	and	and	CCONJ
dti-1351	180	25	1.1	1.1	NUM
dti-1351	180	26	%	%	NOUN
dti-1351	180	27	generously	generously	ADV
dti-1351	180	28	allowed	allow	VERB
dti-1351	180	29	region	region	NOUN
dti-1351	180	30	[	[	X
dti-1351	180	31	table	table	NOUN
dti-1351	180	32	3	3	NUM
dti-1351	180	33	]	]	PUNCT
dti-1351	180	34	and	and	CCONJ
dti-1351	180	35	all	all	DET
dti-1351	180	36	non­glycine	non­glycine	NOUN
dti-1351	180	37	and	and	CCONJ
dti-1351	180	38	non­proline	non­proline	NOUN
dti-1351	180	39	residues	residue	NOUN
dti-1351	180	40	are	be	AUX
dti-1351	180	41	in	in	ADP
dti-1351	180	42	the	the	DET
dti-1351	180	43	allowed	allow	VERB
dti-1351	180	44	region	region	NOUN
dti-1351	180	45	of	of	ADP
dti-1351	180	46	plot	plot	NOUN
dti-1351	180	47	.	.	PUNCT
dti-1351	181	1	verification	verification	NOUN
dti-1351	181	2	was	be	AUX
dti-1351	181	3	also	also	ADV
dti-1351	181	4	done	do	VERB
dti-1351	181	5	with	with	ADP
dti-1351	181	6	verify	verify	VERB
dti-1351	181	7	3d	3d	NUM
dti-1351	181	8	model	model	NOUN
dti-1351	181	9	,	,	PUNCT
dti-1351	181	10	errat	errat	NOUN
dti-1351	181	11	,	,	PUNCT
dti-1351	181	12	3d	3d	PROPN
dti-1351	181	13	match	match	NOUN
dti-1351	181	14	program	program	NOUN
dti-1351	181	15	from	from	ADP
dti-1351	181	16	softberry	softberry	NOUN
dti-1351	181	17	.	.	PUNCT
dti-1351	182	1	figure	figure	NOUN
dti-1351	182	2	5	5	NUM
dti-1351	182	3	.	.	PUNCT
dti-1351	183	1	(	(	PUNCT
dti-1351	183	2	a	a	X
dti-1351	183	3	)	)	PUNCT
dti-1351	183	4	active	active	ADJ
dti-1351	183	5	site	site	NOUN
dti-1351	183	6	information	information	NOUN
dti-1351	183	7	by	by	ADP
dti-1351	183	8	castp	castp	PROPN
dti-1351	183	9	.	.	PUNCT
dti-1351	184	1	green	green	ADJ
dti-1351	184	2	color	color	NOUN
dti-1351	184	3	shows	show	VERB
dti-1351	184	4	the	the	DET
dti-1351	184	5	active	active	ADJ
dti-1351	184	6	site	site	NOUN
dti-1351	184	7	position	position	NOUN
dti-1351	184	8	from	from	ADP
dti-1351	184	9	33	33	NUM
dti-1351	184	10	to	to	ADP
dti-1351	184	11	321	321	NUM
dti-1351	184	12	with	with	ADP
dti-1351	184	13	the	the	DET
dti-1351	184	14	beta	beta	NOUN
dti-1351	184	15	-	-	PUNCT
dti-1351	184	16	sheet	sheet	NOUN
dti-1351	184	17	in	in	ADP
dti-1351	184	18	between	between	ADP
dti-1351	184	19	them	they	PRON
dti-1351	184	20	.	.	PUNCT
dti-1351	185	1	(	(	PUNCT
dti-1351	185	2	b	b	X
dti-1351	185	3	)	)	PUNCT
dti-1351	185	4	the	the	DET
dti-1351	185	5	table	table	NOUN
dti-1351	185	6	shows	show	VERB
dti-1351	185	7	the	the	DET
dti-1351	185	8	area	area	NOUN
dti-1351	185	9	and	and	CCONJ
dti-1351	185	10	the	the	DET
dti-1351	185	11	volume	volume	NOUN
dti-1351	185	12	for	for	ADP
dti-1351	185	13	different	different	ADJ
dti-1351	185	14	active	active	ADJ
dti-1351	185	15	sites	site	NOUN
dti-1351	185	16	of	of	ADP
dti-1351	185	17	cysteine	cysteine	NOUN
dti-1351	185	18	protease	protease	NOUN
dti-1351	185	19	yopt	yopt	NOUN
dti-1351	185	20	and	and	CCONJ
dti-1351	185	21	the	the	DET
dti-1351	185	22	best	good	ADJ
dti-1351	185	23	active	active	ADJ
dti-1351	185	24	site	site	NOUN
dti-1351	185	25	remains	remain	VERB
dti-1351	185	26	in	in	ADP
dti-1351	185	27	an	an	DET
dti-1351	185	28	area	area	NOUN
dti-1351	185	29	of	of	ADP
dti-1351	185	30	1677.7	1677.7	NUM
dti-1351	185	31	and	and	CCONJ
dti-1351	185	32	a	a	DET
dti-1351	185	33	volume	volume	NOUN
dti-1351	185	34	of	of	ADP
dti-1351	185	35	2009.1	2009.1	NUM
dti-1351	185	36	amino	amino	NOUN
dti-1351	185	37	acid	acid	NOUN
dti-1351	185	38	.	.	PUNCT
dti-1351	186	1	(	(	PUNCT
dti-1351	186	2	c	c	X
dti-1351	186	3	)	)	PUNCT
dti-1351	186	4	the	the	DET
dti-1351	186	5	3d	3d	NOUN
dti-1351	186	6	structure	structure	NOUN
dti-1351	186	7	of	of	ADP
dti-1351	186	8	best	good	ADJ
dti-1351	186	9	active	active	ADJ
dti-1351	186	10	site	site	NOUN
dti-1351	186	11	.	.	PUNCT
dti-1351	187	1	http://www.la-press.com	http://www.la-press.com	X
dti-1351	188	1	hasan	hasan	PROPN
dti-1351	188	2	et	et	PROPN
dti-1351	188	3	al	al	PROPN
dti-1351	188	4	8	8	NUM
dti-1351	188	5	drug	drug	NOUN
dti-1351	188	6	target	target	NOUN
dti-1351	188	7	insights	insight	VERB
dti-1351	188	8	2014:8	2014:8	NUM
dti-1351	188	9	findings	finding	NOUN
dti-1351	188	10	of	of	ADP
dti-1351	188	11	verify	verify	VERB
dti-1351	188	12	3d	3d	PROPN
dti-1351	188	13	model	model	NOUN
dti-1351	188	14	,	,	PUNCT
dti-1351	188	15	errat	errat	NOUN
dti-1351	188	16	,	,	PUNCT
dti-1351	188	17	3d	3d	PROPN
dti-1351	188	18	match	match	NOUN
dti-1351	188	19	program	program	NOUN
dti-1351	188	20	and	and	CCONJ
dti-1351	188	21	ramachandran	ramachandran	PROPN
dti-1351	188	22	plot	plot	NOUN
dti-1351	188	23	from	from	ADP
dti-1351	188	24	procheck	procheck	NOUN
dti-1351	188	25	reveals	reveal	VERB
dti-1351	188	26	that	that	SCONJ
dti-1351	188	27	all	all	DET
dti-1351	188	28	residues	residue	NOUN
dti-1351	188	29	are	be	AUX
dti-1351	188	30	within	within	ADP
dti-1351	188	31	the	the	DET
dti-1351	188	32	limits	limit	NOUN
dti-1351	188	33	of	of	ADP
dti-1351	188	34	the	the	DET
dti-1351	188	35	ramachandran	ramachandran	PROPN
dti-1351	188	36	plot	plot	NOUN
dti-1351	188	37	and	and	CCONJ
dti-1351	188	38	hence	hence	ADV
dti-1351	188	39	it	it	PRON
dti-1351	188	40	can	can	AUX
dti-1351	188	41	be	be	AUX
dti-1351	188	42	considered	consider	VERB
dti-1351	188	43	as	as	ADP
dti-1351	188	44	a	a	DET
dti-1351	188	45	good	good	ADJ
dti-1351	188	46	model	model	NOUN
dti-1351	188	47	.	.	PUNCT
dti-1351	189	1	the	the	DET
dti-1351	189	2	high	high	ADJ
dti-1351	189	3	score	score	NOUN
dti-1351	189	4	of	of	ADP
dti-1351	189	5	0.78	0.78	NUM
dti-1351	189	6	in	in	ADP
dti-1351	189	7	the	the	DET
dti-1351	189	8	verify	verify	NOUN
dti-1351	189	9	3d	3d	NOUN
dti-1351	189	10	graph	graph	NOUN
dti-1351	189	11	indicates	indicate	VERB
dti-1351	189	12	that	that	SCONJ
dti-1351	189	13	the	the	DET
dti-1351	189	14	environment	environment	NOUN
dti-1351	189	15	profile	profile	NOUN
dti-1351	189	16	of	of	ADP
dti-1351	189	17	the	the	DET
dti-1351	189	18	model	model	NOUN
dti-1351	189	19	is	be	AUX
dti-1351	189	20	good	good	ADJ
dti-1351	189	21	and	and	CCONJ
dti-1351	189	22	the	the	DET
dti-1351	189	23	overall	overall	ADJ
dti-1351	189	24	quality	quality	NOUN
dti-1351	189	25	of	of	ADP
dti-1351	189	26	model	model	NOUN
dti-1351	189	27	in	in	ADP
dti-1351	189	28	errat	errat	NOUN
dti-1351	189	29	analysis	analysis	NOUN
dti-1351	189	30	was	be	AUX
dti-1351	189	31	85.357	85.357	NUM
dti-1351	189	32	,	,	PUNCT
dti-1351	189	33	expressed	express	VERB
dti-1351	189	34	as	as	ADP
dti-1351	189	35	the	the	DET
dti-1351	189	36	percentage	percentage	NOUN
dti-1351	189	37	of	of	ADP
dti-1351	189	38	the	the	DET
dti-1351	189	39	protein	protein	NOUN
dti-1351	189	40	for	for	ADP
dti-1351	189	41	which	which	PRON
dti-1351	189	42	the	the	DET
dti-1351	189	43	calculated	calculate	VERB
dti-1351	189	44	error	error	NOUN
dti-1351	189	45	value	value	NOUN
dti-1351	189	46	falls	fall	VERB
dti-1351	189	47	below	below	ADP
dti-1351	189	48	95	95	NUM
dti-1351	189	49	%	%	NOUN
dti-1351	189	50	rejection	rejection	NOUN
dti-1351	189	51	limit	limit	NOUN
dti-1351	189	52	.	.	PUNCT
dti-1351	190	1	the	the	DET
dti-1351	190	2	final	final	ADJ
dti-1351	190	3	model	model	NOUN
dti-1351	190	4	of	of	ADP
dti-1351	190	5	target	target	NOUN
dti-1351	190	6	protein	protein	NOUN
dti-1351	190	7	determined	determine	VERB
dti-1351	190	8	through	through	ADP
dti-1351	190	9	swiss	swiss	ADJ
dti-1351	190	10	pdb	pdb	PROPN
dti-1351	190	11	viewer	viewer	NOUN
dti-1351	190	12	is	be	AUX
dti-1351	190	13	shown	show	VERB
dti-1351	190	14	in	in	ADP
dti-1351	190	15	[	[	X
dti-1351	190	16	fig	fig	NOUN
dti-1351	190	17	.	.	PUNCT
dti-1351	191	1	4	4	NUM
dti-1351	191	2	]	]	PUNCT
dti-1351	191	3	.	.	PUNCT
dti-1351	192	1	secondary	secondary	ADJ
dti-1351	192	2	structure	structure	NOUN
dti-1351	192	3	analysis	analysis	NOUN
dti-1351	192	4	of	of	ADP
dti-1351	192	5	the	the	DET
dti-1351	192	6	modeled	model	VERB
dti-1351	192	7	protein	protein	NOUN
dti-1351	192	8	with	with	ADP
dti-1351	192	9	sopma	sopma	NOUN
dti-1351	192	10	reveals	reveal	VERB
dti-1351	192	11	that	that	SCONJ
dti-1351	192	12	it	it	PRON
dti-1351	192	13	contains	contain	VERB
dti-1351	192	14	45.03	45.03	NUM
dti-1351	192	15	%	%	NOUN
dti-1351	192	16	alpha	alpha	NOUN
dti-1351	192	17	helix	helix	NOUN
dti-1351	192	18	,	,	PUNCT
dti-1351	192	19	12.54	12.54	NUM
dti-1351	192	20	%	%	NOUN
dti-1351	192	21	extended	extended	ADJ
dti-1351	192	22	strand	strand	NOUN
dti-1351	192	23	and	and	CCONJ
dti-1351	192	24	33.54	33.54	NUM
dti-1351	192	25	%	%	NOUN
dti-1351	192	26	random	random	ADJ
dti-1351	192	27	coil	coil	NOUN
dti-1351	193	1	[	[	X
dti-1351	193	2	table	table	NOUN
dti-1351	193	3	4	4	NUM
dti-1351	193	4	]	]	PUNCT
dti-1351	193	5	.	.	PUNCT
dti-1351	194	1	the	the	DET
dti-1351	194	2	identification	identification	NOUN
dti-1351	194	3	and	and	CCONJ
dti-1351	194	4	characterization	characterization	NOUN
dti-1351	194	5	of	of	ADP
dti-1351	194	6	functional	functional	ADJ
dti-1351	194	7	sites	site	NOUN
dti-1351	194	8	on	on	ADP
dti-1351	194	9	proteins	protein	NOUN
dti-1351	194	10	has	have	AUX
dti-1351	194	11	increasingly	increasingly	ADV
dti-1351	194	12	become	become	VERB
dti-1351	194	13	an	an	DET
dti-1351	194	14	area	area	NOUN
dti-1351	194	15	of	of	ADP
dti-1351	194	16	interest	interest	NOUN
dti-1351	194	17	.	.	PUNCT
dti-1351	195	1	analysis	analysis	NOUN
dti-1351	195	2	of	of	ADP
dti-1351	195	3	the	the	DET
dti-1351	195	4	active	active	ADJ
dti-1351	195	5	site	site	NOUN
dti-1351	195	6	residues	residue	NOUN
dti-1351	195	7	for	for	ADP
dti-1351	195	8	the	the	DET
dti-1351	195	9	binding	binding	NOUN
dti-1351	195	10	of	of	ADP
dti-1351	195	11	ligands	ligand	NOUN
dti-1351	195	12	provides	provide	VERB
dti-1351	195	13	insight	insight	NOUN
dti-1351	195	14	into	into	ADP
dti-1351	195	15	towards	towards	ADP
dti-1351	195	16	the	the	DET
dti-1351	195	17	design	design	NOUN
dti-1351	195	18	of	of	ADP
dti-1351	195	19	inhibitors	inhibitor	NOUN
dti-1351	195	20	of	of	ADP
dti-1351	195	21	an	an	DET
dti-1351	195	22	enzyme	enzyme	NOUN
dti-1351	195	23	.	.	PUNCT
dti-1351	196	1	in	in	ADP
dti-1351	196	2	this	this	DET
dti-1351	196	3	study	study	NOUN
dti-1351	196	4	,	,	PUNCT
dti-1351	196	5	we	we	PRON
dti-1351	196	6	have	have	AUX
dti-1351	196	7	also	also	ADV
dti-1351	196	8	reported	report	VERB
dti-1351	196	9	the	the	DET
dti-1351	196	10	best	well	ADV
dti-1351	196	11	active	active	ADJ
dti-1351	196	12	site	site	NOUN
dti-1351	196	13	area	area	NOUN
dti-1351	196	14	of	of	ADP
dti-1351	196	15	the	the	DET
dti-1351	196	16	experimental	experimental	ADJ
dti-1351	196	17	enzyme	enzyme	NOUN
dti-1351	196	18	as	as	ADV
dti-1351	196	19	well	well	ADV
dti-1351	196	20	as	as	ADP
dti-1351	196	21	the	the	DET
dti-1351	196	22	number	number	NOUN
dti-1351	196	23	of	of	ADP
dti-1351	196	24	amino	amino	ADJ
dti-1351	196	25	acids	acid	NOUN
dti-1351	196	26	involved	involve	VERB
dti-1351	196	27	in	in	ADP
dti-1351	196	28	it	it	PRON
dti-1351	196	29	.	.	PUNCT
dti-1351	197	1	[	[	X
dti-1351	197	2	fig	fig	NOUN
dti-1351	197	3	.	.	PUNCT
dti-1351	198	1	5	5	NUM
dti-1351	198	2	]	]	PUNCT
dti-1351	198	3	shows	show	VERB
dti-1351	198	4	the	the	DET
dti-1351	198	5	area	area	NOUN
dti-1351	198	6	and	and	CCONJ
dti-1351	198	7	the	the	DET
dti-1351	198	8	volume	volume	NOUN
dti-1351	198	9	for	for	ADP
dti-1351	198	10	different	different	ADJ
dti-1351	198	11	active	active	ADJ
dti-1351	198	12	sites	site	NOUN
dti-1351	198	13	of	of	ADP
dti-1351	198	14	cysteine	cysteine	NOUN
dti-1351	198	15	protease	protease	NOUN
dti-1351	198	16	yopt	yopt	NOUN
dti-1351	198	17	and	and	CCONJ
dti-1351	198	18	the	the	DET
dti-1351	198	19	best	good	ADJ
dti-1351	198	20	active	active	ADJ
dti-1351	198	21	site	site	NOUN
dti-1351	198	22	remains	remain	VERB
dti-1351	198	23	in	in	ADP
dti-1351	198	24	an	an	DET
dti-1351	198	25	area	area	NOUN
dti-1351	198	26	of	of	ADP
dti-1351	198	27	1677.7	1677.7	NUM
dti-1351	198	28	and	and	CCONJ
dti-1351	198	29	a	a	DET
dti-1351	198	30	volume	volume	NOUN
dti-1351	198	31	of	of	ADP
dti-1351	198	32	2009.1	2009.1	NUM
dti-1351	198	33	amino	amino	NOUN
dti-1351	198	34	acids	acid	NOUN
dti-1351	198	35	.	.	PUNCT
dti-1351	199	1	in	in	ADP
dti-1351	199	2	addition	addition	NOUN
dti-1351	199	3	,	,	PUNCT
dti-1351	199	4	it	it	PRON
dti-1351	199	5	is	be	AUX
dti-1351	199	6	desirable	desirable	ADJ
dti-1351	199	7	to	to	PART
dti-1351	199	8	identify	identify	VERB
dti-1351	199	9	which	which	PRON
dti-1351	199	10	properties	property	NOUN
dti-1351	199	11	of	of	ADP
dti-1351	199	12	active	active	ADJ
dti-1351	199	13	residues	residue	NOUN
dti-1351	199	14	are	be	AUX
dti-1351	199	15	required	require	VERB
dti-1351	199	16	for	for	ADP
dti-1351	199	17	catalysis	catalysis	NOUN
dti-1351	199	18	and/or	and/or	CCONJ
dti-1351	199	19	recognition	recognition	NOUN
dti-1351	199	20	,	,	PUNCT
dti-1351	199	21	in	in	ADP
dti-1351	199	22	order	order	NOUN
dti-1351	199	23	to	to	PART
dti-1351	199	24	understand	understand	VERB
dti-1351	199	25	how	how	SCONJ
dti-1351	199	26	one	one	PRON
dti-1351	199	27	might	might	AUX
dti-1351	199	28	engineer	engineer	VERB
dti-1351	199	29	these	these	DET
dti-1351	199	30	properties	property	NOUN
dti-1351	199	31	into	into	ADP
dti-1351	199	32	a	a	DET
dti-1351	199	33	protein	protein	NOUN
dti-1351	199	34	scaffold	scaffold	NOUN
dti-1351	199	35	to	to	PART
dti-1351	199	36	design	design	VERB
dti-1351	199	37	an	an	DET
dti-1351	199	38	enzymatic	enzymatic	ADJ
dti-1351	199	39	species	specie	NOUN
dti-1351	199	40	with	with	ADP
dti-1351	199	41	a	a	DET
dti-1351	199	42	specified	specified	ADJ
dti-1351	199	43	type	type	NOUN
dti-1351	199	44	of	of	ADP
dti-1351	199	45	reactivity.46	reactivity.46	PROPN
dti-1351	199	46	conclusion	conclusion	NOUN
dti-1351	199	47	in	in	ADP
dti-1351	199	48	this	this	DET
dti-1351	199	49	study	study	NOUN
dti-1351	199	50	,	,	PUNCT
dti-1351	199	51	the	the	DET
dti-1351	199	52	3d	3d	NUM
dti-1351	199	53	structure	structure	NOUN
dti-1351	199	54	of	of	ADP
dti-1351	199	55	cysteine	cysteine	NOUN
dti-1351	199	56	protease	protease	NOUN
dti-1351	199	57	yopt	yopt	PROPN
dti-1351	199	58	from	from	ADP
dti-1351	199	59	yersinia	yersinia	PROPN
dti-1351	199	60	pestis	pestis	PROPN
dti-1351	199	61	was	be	AUX
dti-1351	199	62	predicted	predict	VERB
dti-1351	199	63	and	and	CCONJ
dti-1351	199	64	validated	validate	VERB
dti-1351	199	65	by	by	ADP
dti-1351	199	66	various	various	ADJ
dti-1351	199	67	bioinfor­	bioinfor­	NOUN
dti-1351	199	68	matics	matic	NOUN
dti-1351	199	69	tools	tool	NOUN
dti-1351	199	70	and	and	CCONJ
dti-1351	199	71	software	software	NOUN
dti-1351	199	72	.	.	PUNCT
dti-1351	200	1	it	it	PRON
dti-1351	200	2	is	be	AUX
dti-1351	200	3	obvious	obvious	ADJ
dti-1351	200	4	that	that	SCONJ
dti-1351	200	5	this	this	DET
dti-1351	200	6	enzyme	enzyme	NOUN
dti-1351	200	7	is	be	AUX
dti-1351	200	8	the	the	DET
dti-1351	200	9	most	most	ADV
dti-1351	200	10	important	important	ADJ
dti-1351	200	11	factor	factor	NOUN
dti-1351	200	12	used	use	VERB
dti-1351	200	13	by	by	ADP
dti-1351	200	14	yersinia	yersinia	PROPN
dti-1351	200	15	pestis	pestis	PROPN
dti-1351	200	16	for	for	ADP
dti-1351	200	17	its	its	PRON
dti-1351	200	18	pathogene­	pathogene­	PROPN
dti-1351	200	19	sis	sis	NOUN
dti-1351	200	20	in	in	ADP
dti-1351	200	21	host	host	NOUN
dti-1351	200	22	.	.	PUNCT
dti-1351	201	1	on	on	ADP
dti-1351	201	2	the	the	DET
dti-1351	201	3	basis	basis	NOUN
dti-1351	201	4	of	of	ADP
dti-1351	201	5	our	our	PRON
dti-1351	201	6	findings	finding	NOUN
dti-1351	201	7	,	,	PUNCT
dti-1351	201	8	it	it	PRON
dti-1351	201	9	could	could	AUX
dti-1351	201	10	be	be	AUX
dti-1351	201	11	concluded	conclude	VERB
dti-1351	201	12	that	that	SCONJ
dti-1351	201	13	advance	advance	NOUN
dti-1351	201	14	characterization	characterization	NOUN
dti-1351	201	15	of	of	ADP
dti-1351	201	16	cysteine	cysteine	NOUN
dti-1351	201	17	protease	protease	NOUN
dti-1351	201	18	yopt	yopt	PROPN
dti-1351	201	19	from	from	ADP
dti-1351	201	20	yersinia	yersinia	PROPN
dti-1351	201	21	pestis	pestis	PROPN
dti-1351	201	22	will	will	AUX
dti-1351	201	23	be	be	AUX
dti-1351	201	24	important	important	ADJ
dti-1351	201	25	for	for	ADP
dti-1351	201	26	the	the	DET
dti-1351	201	27	regulation	regulation	NOUN
dti-1351	201	28	of	of	ADP
dti-1351	201	29	plague	plague	NOUN
dti-1351	201	30	.	.	PUNCT
dti-1351	202	1	further	further	ADJ
dti-1351	202	2	broad	broad	ADJ
dti-1351	202	3	screening	screen	VERB
dti-1351	202	4	inhibitors	inhibitor	NOUN
dti-1351	202	5	against	against	ADP
dti-1351	202	6	this	this	DET
dti-1351	202	7	enzyme	enzyme	NOUN
dti-1351	202	8	will	will	AUX
dti-1351	202	9	help	help	VERB
dti-1351	202	10	for	for	ADP
dti-1351	202	11	effective	effective	ADJ
dti-1351	202	12	drug	drug	NOUN
dti-1351	202	13	designing	design	VERB
dti-1351	202	14	in	in	ADP
dti-1351	202	15	future	future	NOUN
dti-1351	202	16	.	.	PUNCT
dti-1351	203	1	author	author	NOUN
dti-1351	203	2	contributions	contribution	NOUN
dti-1351	203	3	conceived	conceive	VERB
dti-1351	203	4	and	and	CCONJ
dti-1351	203	5	designed	design	VERB
dti-1351	203	6	the	the	DET
dti-1351	203	7	experiments	experiment	NOUN
dti-1351	203	8	:	:	PUNCT
dti-1351	203	9	mah	mah	PROPN
dti-1351	203	10	.	.	PROPN
dti-1351	203	11	analyzed	analyze	VERB
dti-1351	203	12	the	the	DET
dti-1351	203	13	data	datum	NOUN
dti-1351	203	14	:	:	PUNCT
dti-1351	203	15	mah	mah	PROPN
dti-1351	203	16	,	,	PUNCT
dti-1351	203	17	sma	sma	PROPN
dti-1351	203	18	.	.	PROPN
dti-1351	203	19	wrote	write	VERB
dti-1351	203	20	the	the	DET
dti-1351	203	21	first	first	ADJ
dti-1351	203	22	draft	draft	NOUN
dti-1351	203	23	of	of	ADP
dti-1351	203	24	the	the	DET
dti-1351	203	25	manu­	manu­	PROPN
dti-1351	203	26	script	script	NOUN
dti-1351	203	27	:	:	PUNCT
dti-1351	203	28	mah	mah	PROPN
dti-1351	203	29	,	,	PUNCT
dti-1351	203	30	maa	maa	PROPN
dti-1351	203	31	,	,	PUNCT
dti-1351	203	32	smn	smn	PROPN
dti-1351	203	33	.	.	PROPN
dti-1351	203	34	contributed	contribute	VERB
dti-1351	203	35	to	to	ADP
dti-1351	203	36	the	the	DET
dti-1351	203	37	writing	writing	NOUN
dti-1351	203	38	of	of	ADP
dti-1351	203	39	the	the	DET
dti-1351	203	40	manuscript	manuscript	NOUN
dti-1351	203	41	:	:	PUNCT
dti-1351	203	42	mah	mah	PROPN
dti-1351	203	43	,	,	PUNCT
dti-1351	203	44	maa	maa	PROPN
dti-1351	203	45	,	,	PUNCT
dti-1351	203	46	am	be	AUX
dti-1351	203	47	.	.	PUNCT
dti-1351	204	1	agree	agree	VERB
dti-1351	204	2	with	with	ADP
dti-1351	204	3	manuscript	manuscript	NOUN
dti-1351	204	4	results	result	NOUN
dti-1351	204	5	and	and	CCONJ
dti-1351	204	6	conclusions	conclusion	NOUN
dti-1351	204	7	:	:	PUNCT
dti-1351	204	8	mah	mah	PROPN
dti-1351	204	9	,	,	PUNCT
dti-1351	204	10	maa	maa	PROPN
dti-1351	204	11	,	,	PUNCT
dti-1351	204	12	smn	smn	PROPN
dti-1351	204	13	,	,	PUNCT
dti-1351	204	14	sma	sma	PROPN
dti-1351	204	15	,	,	PUNCT
dti-1351	204	16	am	be	AUX
dti-1351	204	17	.	.	PUNCT
dti-1351	205	1	jointly	jointly	ADV
dti-1351	205	2	devel	devel	NOUN
dti-1351	205	3	oped	ope	VERB
dti-1351	205	4	the	the	DET
dti-1351	205	5	structure	structure	NOUN
dti-1351	205	6	and	and	CCONJ
dti-1351	205	7	arguments	argument	NOUN
dti-1351	205	8	for	for	ADP
dti-1351	205	9	the	the	DET
dti-1351	205	10	paper	paper	NOUN
dti-1351	205	11	:	:	PUNCT
dti-1351	205	12	mah	mah	PROPN
dti-1351	205	13	,	,	PUNCT
dti-1351	205	14	smn	smn	PROPN
dti-1351	205	15	,	,	PUNCT
dti-1351	205	16	am	be	AUX
dti-1351	205	17	.	.	PUNCT
dti-1351	206	1	made	make	VERB
dti-1351	206	2	critical	critical	ADJ
dti-1351	206	3	revisions	revision	NOUN
dti-1351	206	4	and	and	CCONJ
dti-1351	206	5	approved	approve	VERB
dti-1351	206	6	in	in	ADP
dti-1351	206	7	all	all	DET
dti-1351	206	8	version	version	NOUN
dti-1351	206	9	:	:	PUNCT
dti-1351	206	10	mah	mah	PROPN
dti-1351	206	11	.	.	PUNCT
dti-1351	207	1	all	all	DET
dti-1351	207	2	authors	author	NOUN
dti-1351	207	3	reviewed	review	VERB
dti-1351	207	4	and	and	CCONJ
dti-1351	207	5	approved	approve	VERB
dti-1351	207	6	of	of	ADP
dti-1351	207	7	the	the	PRON
dti-1351	207	8	in	in	ADP
dti-1351	207	9	all	all	DET
dti-1351	207	10	manuscript	manuscript	NOUN
dti-1351	207	11	.	.	PUNCT
dti-1351	208	1	disclosures	disclosure	NOUN
dti-1351	208	2	and	and	CCONJ
dti-1351	208	3	ethics	ethic	NOUN
dti-1351	208	4	as	as	ADP
dti-1351	208	5	a	a	DET
dti-1351	208	6	requirement	requirement	NOUN
dti-1351	208	7	of	of	ADP
dti-1351	208	8	publication	publication	NOUN
dti-1351	208	9	the	the	DET
dti-1351	208	10	authors	author	NOUN
dti-1351	208	11	have	have	AUX
dti-1351	208	12	provided	provide	VERB
dti-1351	208	13	signed	sign	VERB
dti-1351	208	14	confirmation	confirmation	NOUN
dti-1351	208	15	of	of	ADP
dti-1351	208	16	their	their	PRON
dti-1351	208	17	compliance	compliance	NOUN
dti-1351	208	18	with	with	ADP
dti-1351	208	19	ethical	ethical	ADJ
dti-1351	208	20	and	and	CCONJ
dti-1351	208	21	legal	legal	ADJ
dti-1351	208	22	obligations	obligation	NOUN
dti-1351	208	23	including	include	VERB
dti-1351	208	24	but	but	CCONJ
dti-1351	208	25	not	not	PART
dti-1351	208	26	limited	limit	VERB
dti-1351	208	27	to	to	ADP
dti-1351	208	28	compliance	compliance	NOUN
dti-1351	208	29	with	with	ADP
dti-1351	208	30	icmje	icmje	NOUN
dti-1351	208	31	authorship	authorship	NOUN
dti-1351	208	32	and	and	CCONJ
dti-1351	208	33	competing	compete	VERB
dti-1351	208	34	interests	interest	NOUN
dti-1351	208	35	guidelines	guideline	NOUN
dti-1351	208	36	,	,	PUNCT
dti-1351	208	37	that	that	SCONJ
dti-1351	208	38	the	the	DET
dti-1351	208	39	article	article	NOUN
dti-1351	208	40	is	be	AUX
dti-1351	208	41	neither	neither	CCONJ
dti-1351	208	42	under	under	ADP
dti-1351	208	43	consideration	consideration	NOUN
dti-1351	208	44	for	for	ADP
dti-1351	208	45	publication	publication	NOUN
dti-1351	208	46	nor	nor	CCONJ
dti-1351	208	47	published	publish	VERB
dti-1351	208	48	elsewhere	elsewhere	ADV
dti-1351	208	49	,	,	PUNCT
dti-1351	208	50	of	of	ADP
dti-1351	208	51	their	their	PRON
dti-1351	208	52	compliance	compliance	NOUN
dti-1351	208	53	with	with	ADP
dti-1351	208	54	legal	legal	ADJ
dti-1351	208	55	and	and	CCONJ
dti-1351	208	56	ethical	ethical	ADJ
dti-1351	208	57	guidelines	guideline	NOUN
dti-1351	208	58	concerning	concern	VERB
dti-1351	208	59	human	human	ADJ
dti-1351	208	60	and	and	CCONJ
dti-1351	208	61	animal	animal	NOUN
dti-1351	208	62	research	research	NOUN
dti-1351	208	63	participants	participant	NOUN
dti-1351	208	64	(	(	PUNCT
dti-1351	208	65	if	if	SCONJ
dti-1351	208	66	applicable	applicable	ADJ
dti-1351	208	67	)	)	PUNCT
dti-1351	208	68	,	,	PUNCT
dti-1351	208	69	and	and	CCONJ
dti-1351	208	70	that	that	DET
dti-1351	208	71	permission	permission	NOUN
dti-1351	208	72	has	have	AUX
dti-1351	208	73	been	be	AUX
dti-1351	208	74	obtained	obtain	VERB
dti-1351	208	75	for	for	ADP
dti-1351	208	76	reproduction	reproduction	NOUN
dti-1351	208	77	of	of	ADP
dti-1351	208	78	any	any	DET
dti-1351	208	79	copyrighted	copyright	VERB
dti-1351	208	80	material	material	NOUN
dti-1351	208	81	.	.	PUNCT
dti-1351	209	1	this	this	DET
dti-1351	209	2	article	article	NOUN
dti-1351	209	3	was	be	AUX
dti-1351	209	4	subject	subject	ADJ
dti-1351	209	5	to	to	ADP
dti-1351	209	6	blind	blind	ADJ
dti-1351	209	7	,	,	PUNCT
dti-1351	209	8	independent	independent	ADJ
dti-1351	209	9	,	,	PUNCT
dti-1351	209	10	expert	expert	ADJ
dti-1351	209	11	peer	peer	NOUN
dti-1351	209	12	review	review	NOUN
dti-1351	209	13	.	.	PUNCT
dti-1351	210	1	the	the	DET
dti-1351	210	2	reviewers	reviewer	NOUN
dti-1351	210	3	reported	report	VERB
dti-1351	210	4	no	no	DET
dti-1351	210	5	competing	compete	VERB
dti-1351	210	6	interests	interest	NOUN
dti-1351	210	7	.	.	PUNCT
dti-1351	211	1	references	reference	NOUN
dti-1351	211	2	1	1	NUM
dti-1351	211	3	.	.	PUNCT
dti-1351	211	4	riedel	riedel	PROPN
dti-1351	211	5	s.	s.	PROPN
dti-1351	211	6	plague	plague	PROPN
dti-1351	211	7	:	:	PUNCT
dti-1351	211	8	from	from	ADP
dti-1351	211	9	natural	natural	ADJ
dti-1351	211	10	disease	disease	NOUN
dti-1351	211	11	to	to	ADP
dti-1351	211	12	bioterrorism	bioterrorism	NOUN
dti-1351	211	13	.	.	PUNCT
dti-1351	212	1	proc	proc	NOUN
dti-1351	212	2	(	(	PUNCT
dti-1351	212	3	bayl	bayl	PROPN
dti-1351	212	4	univ	univ	PROPN
dti-1351	212	5	med	med	PROPN
dti-1351	212	6	cent	cent	NOUN
dti-1351	212	7	)	)	PUNCT
dti-1351	212	8	.	.	PUNCT
dti-1351	213	1	2005;18:116–124	2005;18:116–124	NOUN
dti-1351	213	2	.	.	PUNCT
dti-1351	214	1	2	2	X
dti-1351	214	2	.	.	X
dti-1351	214	3	stenseth	stenseth	PROPN
dti-1351	214	4	nc	nc	PROPN
dti-1351	214	5	,	,	PUNCT
dti-1351	214	6	atshabar	atshabar	PROPN
dti-1351	214	7	bb	bb	PROPN
dti-1351	214	8	,	,	PUNCT
dti-1351	214	9	begon	begon	PROPN
dti-1351	214	10	m	m	PROPN
dti-1351	214	11	,	,	PUNCT
dti-1351	214	12	et	et	PROPN
dti-1351	214	13	al	al	PROPN
dti-1351	214	14	.	.	PUNCT
dti-1351	214	15	plague	plague	PROPN
dti-1351	214	16	:	:	PUNCT
dti-1351	214	17	past	past	ADJ
dti-1351	214	18	,	,	PUNCT
dti-1351	214	19	present	present	ADJ
dti-1351	214	20	and	and	CCONJ
dti-1351	214	21	future	future	NOUN
dti-1351	214	22	.	.	PUNCT
dti-1351	215	1	plos	plos	PROPN
dti-1351	215	2	med	med	PROPN
dti-1351	215	3	.	.	PUNCT
dti-1351	216	1	2008;5	2008;5	X
dti-1351	216	2	:	:	PUNCT
dti-1351	216	3	e3	e3	NOUN
dti-1351	216	4	.	.	PUNCT
dti-1351	217	1	3	3	X
dti-1351	217	2	.	.	X
dti-1351	217	3	parkhill	parkhill	PROPN
dti-1351	217	4	j	j	PROPN
dti-1351	217	5	,	,	PUNCT
dti-1351	217	6	wren	wren	PROPN
dti-1351	217	7	bw	bw	PROPN
dti-1351	217	8	,	,	PUNCT
dti-1351	217	9	thomson	thomson	PROPN
dti-1351	217	10	nr	nr	PROPN
dti-1351	217	11	,	,	PUNCT
dti-1351	217	12	et	et	PROPN
dti-1351	217	13	al	al	PROPN
dti-1351	217	14	.	.	PROPN
dti-1351	217	15	genome	genome	NOUN
dti-1351	217	16	sequence	sequence	NOUN
dti-1351	217	17	of	of	ADP
dti-1351	217	18	yersinia	yersinia	PROPN
dti-1351	217	19	pestis	pestis	PROPN
dti-1351	217	20	,	,	PUNCT
dti-1351	217	21	the	the	DET
dti-1351	217	22	causative	causative	ADJ
dti-1351	217	23	agent	agent	NOUN
dti-1351	217	24	of	of	ADP
dti-1351	217	25	plague	plague	NOUN
dti-1351	217	26	.	.	PUNCT
dti-1351	218	1	nature	nature	NOUN
dti-1351	218	2	.	.	PUNCT
dti-1351	219	1	2001;413:523–27	2001;413:523–27	X
dti-1351	219	2	.	.	PROPN
dti-1351	219	3	4	4	NUM
dti-1351	219	4	.	.	X
dti-1351	219	5	quenee	quenee	PROPN
dti-1351	219	6	le	le	PROPN
dti-1351	219	7	,	,	PUNCT
dti-1351	219	8	ciletti	ciletti	PROPN
dti-1351	219	9	na	na	PROPN
dti-1351	219	10	,	,	PUNCT
dti-1351	219	11	elli	elli	PROPN
dti-1351	219	12	d	d	PROPN
dti-1351	219	13	,	,	PUNCT
dti-1351	219	14	hermanas	hermanas	PROPN
dti-1351	219	15	tm	tm	PROPN
dti-1351	219	16	,	,	PUNCT
dti-1351	219	17	schneewind	schneewind	ADJ
dti-1351	219	18	o.	o.	PROPN
dti-1351	219	19	prevention	prevention	NOUN
dti-1351	219	20	of	of	ADP
dti-1351	219	21	pneumonic	pneumonic	ADJ
dti-1351	219	22	plague	plague	NOUN
dti-1351	219	23	in	in	ADP
dti-1351	219	24	mice	mouse	NOUN
dti-1351	219	25	,	,	PUNCT
dti-1351	219	26	rats	rat	NOUN
dti-1351	219	27	,	,	PUNCT
dti-1351	219	28	guinea	guinea	NOUN
dti-1351	219	29	pigs	pig	NOUN
dti-1351	219	30	and	and	CCONJ
dti-1351	219	31	non­human	non­human	NOUN
dti-1351	219	32	primates	primate	NOUN
dti-1351	219	33	with	with	ADP
dti-1351	219	34	clini­	clini­	NOUN
dti-1351	219	35	cal	cal	ADJ
dti-1351	219	36	grade	grade	NOUN
dti-1351	219	37	rv10	rv10	PROPN
dti-1351	219	38	,	,	PUNCT
dti-1351	219	39	rv10–2	rv10–2	PROPN
dti-1351	219	40	or	or	CCONJ
dti-1351	219	41	f1­vvaccines	f1­vvaccine	NOUN
dti-1351	219	42	.	.	PUNCT
dti-1351	219	43	vaccine	vaccine	NOUN
dti-1351	219	44	.	.	PUNCT
dti-1351	220	1	2011;29:6572–83	2011;29:6572–83	NUM
dti-1351	220	2	.	.	NOUN
dti-1351	220	3	5	5	NUM
dti-1351	220	4	.	.	X
dti-1351	220	5	swietnicki	swietnicki	PROPN
dti-1351	220	6	w	w	PROPN
dti-1351	220	7	,	,	PUNCT
dti-1351	220	8	carmany	carmany	NOUN
dti-1351	220	9	d	d	NOUN
dti-1351	220	10	,	,	PUNCT
dti-1351	220	11	retford	retford	NOUN
dti-1351	220	12	m	m	PROPN
dti-1351	220	13	,	,	PUNCT
dti-1351	220	14	et	et	PROPN
dti-1351	220	15	al	al	PROPN
dti-1351	220	16	.	.	PUNCT
dti-1351	220	17	identification	identification	NOUN
dti-1351	220	18	of	of	ADP
dti-1351	220	19	small­molecule	small­molecule	ADJ
dti-1351	220	20	inhibitors	inhibitor	NOUN
dti-1351	220	21	of	of	ADP
dti-1351	220	22	yersinia	yersinia	PROPN
dti-1351	220	23	pestis	pestis	PROPN
dti-1351	220	24	type	type	NOUN
dti-1351	220	25	iii	iii	NUM
dti-1351	220	26	secretion	secretion	NOUN
dti-1351	220	27	system	system	NOUN
dti-1351	220	28	yscn	yscn	PROPN
dti-1351	220	29	atpase	atpase	PROPN
dti-1351	220	30	.	.	PUNCT
dti-1351	221	1	plos	plos	PROPN
dti-1351	221	2	one	one	NUM
dti-1351	221	3	.	.	PUNCT
dti-1351	222	1	2011;6	2011;6	NUM
dti-1351	222	2	:	:	PUNCT
dti-1351	222	3	e19716	e19716	NOUN
dti-1351	222	4	.	.	NOUN
dti-1351	223	1	6	6	NUM
dti-1351	223	2	.	.	X
dti-1351	223	3	ryan	ryan	PROPN
dti-1351	223	4	kj	kj	PROPN
dti-1351	223	5	,	,	PUNCT
dti-1351	223	6	ray	ray	PROPN
dti-1351	223	7	cg	cg	PROPN
dti-1351	223	8	(	(	PUNCT
dti-1351	223	9	eds	ed	NOUN
dti-1351	223	10	)	)	PUNCT
dti-1351	223	11	.	.	PUNCT
dti-1351	224	1	sherris	sherris	PROPN
dti-1351	224	2	medical	medical	ADJ
dti-1351	224	3	microbiology	microbiology	NOUN
dti-1351	224	4	.	.	PUNCT
dti-1351	225	1	4th	4th	ADJ
dti-1351	225	2	edition	edition	PROPN
dti-1351	225	3	.	.	PUNCT
dti-1351	226	1	mcgraw	mcgraw	PROPN
dti-1351	226	2	hill	hill	PROPN
dti-1351	226	3	.	.	PUNCT
dti-1351	227	1	2004;484–8	2004;484–8	NOUN
dti-1351	227	2	.	.	PUNCT
dti-1351	228	1	isbn	isbn	PROPN
dti-1351	228	2	0–8385–8529–9	0–8385–8529–9	PROPN
dti-1351	228	3	.	.	PUNCT
dti-1351	229	1	7	7	X
dti-1351	229	2	.	.	X
dti-1351	229	3	yersin	yersin	PROPN
dti-1351	229	4	a.	a.	PROPN
dti-1351	229	5	la	la	PROPN
dti-1351	229	6	peste	peste	PROPN
dti-1351	229	7	bubonique	bubonique	PROPN
dti-1351	229	8	a	a	DET
dti-1351	229	9	`	`	PUNCT
dti-1351	229	10	hong	hong	PROPN
dti-1351	229	11	kong	kong	PROPN
dti-1351	229	12	.	.	PUNCT
dti-1351	230	1	ann	ann	PROPN
dti-1351	230	2	inst	inst	PROPN
dti-1351	230	3	pasteur	pasteur	PROPN
dti-1351	230	4	paris	paris	PROPN
dti-1351	230	5	.	.	PUNCT
dti-1351	231	1	1894;8	1894;8	NUM
dti-1351	231	2	:	:	PUNCT
dti-1351	232	1	662–7	662–7	NUM
dti-1351	232	2	.	.	NOUN
dti-1351	232	3	8	8	NUM
dti-1351	232	4	.	.	PUNCT
dti-1351	232	5	yersin	yersin	PROPN
dti-1351	232	6	a	a	PRON
dti-1351	232	7	.	.	PUNCT
dti-1351	233	1	la	la	PROPN
dti-1351	233	2	peste	peste	PROPN
dti-1351	233	3	bubonique	bubonique	PROPN
dti-1351	233	4	à	à	PROPN
dti-1351	233	5	hong	hong	PROPN
dti-1351	233	6	kong	kong	PROPN
dti-1351	233	7	.	.	PUNCT
dti-1351	234	1	archives	archive	NOUN
dti-1351	234	2	de	de	PROPN
dti-1351	234	3	me´decine	me´decine	NOUN
dti-1351	234	4	navales.1894;62	navales.1894;62	NOUN
dti-1351	234	5	:	:	PUNCT
dti-1351	234	6	256–61	256–61	NUM
dti-1351	234	7	.	.	X
dti-1351	235	1	9	9	NUM
dti-1351	235	2	.	.	X
dti-1351	235	3	perry	perry	PROPN
dti-1351	235	4	rd	rd	PROPN
dti-1351	235	5	,	,	PUNCT
dti-1351	235	6	fetherston	fetherston	PROPN
dti-1351	235	7	jd	jd	PROPN
dti-1351	235	8	.	.	PROPN
dti-1351	235	9	yersinia	yersinia	PROPN
dti-1351	235	10	pestis	pestis	PROPN
dti-1351	235	11	etiologic	etiologic	ADJ
dti-1351	235	12	agent	agent	NOUN
dti-1351	235	13	of	of	ADP
dti-1351	235	14	plague	plague	NOUN
dti-1351	235	15	.	.	PUNCT
dti-1351	236	1	clin	clin	PROPN
dti-1351	236	2	microbiol	microbiol	PROPN
dti-1351	236	3	rev	rev	VERB
dti-1351	236	4	.	.	PROPN
dti-1351	236	5	1997;10:35–66	1997;10:35–66	NUM
dti-1351	236	6	.	.	PROPN
dti-1351	236	7	10	10	NUM
dti-1351	236	8	.	.	PUNCT
dti-1351	237	1	deng	deng	PROPN
dti-1351	237	2	w	w	PROPN
dti-1351	237	3	,	,	PUNCT
dti-1351	237	4	et	et	PROPN
dti-1351	237	5	al	al	PROPN
dti-1351	237	6	.	.	PROPN
dti-1351	237	7	genome	genome	NOUN
dti-1351	237	8	sequence	sequence	NOUN
dti-1351	237	9	of	of	ADP
dti-1351	237	10	yersinia	yersinia	PROPN
dti-1351	237	11	pestis	pestis	PROPN
dti-1351	237	12	kim	kim	PROPN
dti-1351	237	13	.	.	PROPN
dti-1351	238	1	journal	journal	PROPN
dti-1351	238	2	of	of	ADP
dti-1351	238	3	bacteriology	bacteriology	NOUN
dti-1351	238	4	.	.	PUNCT
dti-1351	239	1	2002;184:4601–11	2002;184:4601–11	X
dti-1351	239	2	.	.	PROPN
dti-1351	239	3	11	11	NUM
dti-1351	239	4	.	.	PUNCT
dti-1351	240	1	cowan	cowan	PROPN
dti-1351	240	2	c	c	PROPN
dti-1351	240	3	,	,	PUNCT
dti-1351	240	4	jones	jones	PROPN
dti-1351	240	5	ha	ha	PROPN
dti-1351	240	6	,	,	PUNCT
dti-1351	240	7	kaya	kaya	PROPN
dti-1351	240	8	yh	yh	PROPN
dti-1351	240	9	,	,	PUNCT
dti-1351	240	10	perry	perry	PROPN
dti-1351	240	11	rd	rd	PROPN
dti-1351	240	12	,	,	PUNCT
dti-1351	240	13	straley	straley	PROPN
dti-1351	240	14	sc	sc	PROPN
dti-1351	240	15	.	.	PROPN
dti-1351	240	16	invasion	invasion	NOUN
dti-1351	240	17	of	of	ADP
dti-1351	240	18	epithelial	epithelial	ADJ
dti-1351	240	19	cells	cell	NOUN
dti-1351	240	20	by	by	ADP
dti-1351	240	21	yersinia	yersinia	PROPN
dti-1351	240	22	pestis	pestis	PROPN
dti-1351	240	23	:	:	PUNCT
dti-1351	240	24	evidence	evidence	NOUN
dti-1351	240	25	for	for	ADP
dti-1351	240	26	a	a	DET
dti-1351	240	27	y.	y.	PROPN
dti-1351	240	28	pestis­specific	pestis­specific	PROPN
dti-1351	240	29	invasion	invasion	NOUN
dti-1351	240	30	.	.	PUNCT
dti-1351	241	1	infect	infect	VERB
dti-1351	241	2	.	.	PUNCT
dti-1351	242	1	immun	immun	PROPN
dti-1351	242	2	.	.	PUNCT
dti-1351	243	1	2000;68	2000;68	NUM
dti-1351	243	2	:	:	PUNCT
dti-1351	243	3	4523–30	4523–30	NUM
dti-1351	243	4	.	.	PUNCT
dti-1351	244	1	12	12	NUM
dti-1351	244	2	.	.	PUNCT
dti-1351	245	1	cornelis	cornelis	PROPN
dti-1351	245	2	gr	gr	PROPN
dti-1351	245	3	,	,	PUNCT
dti-1351	245	4	boland	boland	PROPN
dti-1351	245	5	a	a	X
dti-1351	245	6	,	,	PUNCT
dti-1351	245	7	boyd	boyd	PROPN
dti-1351	245	8	ap	ap	PROPN
dti-1351	245	9	,	,	PUNCT
dti-1351	245	10	et	et	PROPN
dti-1351	245	11	al	al	PROPN
dti-1351	245	12	.	.	PUNCT
dti-1351	246	1	the	the	DET
dti-1351	246	2	virulence	virulence	NOUN
dti-1351	246	3	plasmid	plasmid	NOUN
dti-1351	246	4	of	of	ADP
dti-1351	246	5	yersinia	yersinia	NOUN
dti-1351	246	6	,	,	PUNCT
dti-1351	246	7	an	an	DET
dti-1351	246	8	antihost	antihost	NOUN
dti-1351	246	9	genome	genome	NOUN
dti-1351	246	10	.	.	PUNCT
dti-1351	247	1	microbiol	microbiol	PROPN
dti-1351	247	2	mol	mol	ADP
dti-1351	247	3	biol	biol	PROPN
dti-1351	247	4	rev	rev	VERB
dti-1351	247	5	.	.	PROPN
dti-1351	248	1	1998;62:1315–52	1998;62:1315–52	NUM
dti-1351	248	2	.	.	NOUN
dti-1351	249	1	13	13	NUM
dti-1351	249	2	.	.	PUNCT
dti-1351	250	1	hueck	hueck	PROPN
dti-1351	250	2	cj	cj	PROPN
dti-1351	250	3	.	.	PUNCT
dti-1351	250	4	type	type	NOUN
dti-1351	250	5	iii	iii	NUM
dti-1351	250	6	protein	protein	NOUN
dti-1351	250	7	secretion	secretion	NOUN
dti-1351	250	8	systems	system	NOUN
dti-1351	250	9	in	in	ADP
dti-1351	250	10	bacterial	bacterial	ADJ
dti-1351	250	11	pathogens	pathogen	NOUN
dti-1351	250	12	of	of	ADP
dti-1351	250	13	animals	animal	NOUN
dti-1351	250	14	and	and	CCONJ
dti-1351	250	15	plants	plant	NOUN
dti-1351	250	16	.	.	PUNCT
dti-1351	251	1	microbiol	microbiol	PROPN
dti-1351	251	2	mol	mol	ADP
dti-1351	251	3	biol	biol	PROPN
dti-1351	251	4	rev	rev	PROPN
dti-1351	251	5	.	.	PUNCT
dti-1351	252	1	1998;62:379–433	1998;62:379–433	NUM
dti-1351	252	2	.	.	PROPN
dti-1351	253	1	14	14	NUM
dti-1351	253	2	.	.	PUNCT
dti-1351	254	1	cornelis	cornelis	PROPN
dti-1351	254	2	gr	gr	PROPN
dti-1351	254	3	.	.	PUNCT
dti-1351	255	1	the	the	DET
dti-1351	255	2	yersinia	yersinia	PROPN
dti-1351	255	3	ysc­yop	ysc­yop	PROPN
dti-1351	255	4	‘	'	PUNCT
dti-1351	255	5	type	type	NOUN
dti-1351	255	6	iii	iii	NOUN
dti-1351	255	7	’	'	PUNCT
dti-1351	255	8	weaponry	weaponry	NOUN
dti-1351	255	9	.	.	PUNCT
dti-1351	256	1	nat	nat	PROPN
dti-1351	256	2	rev	rev	VERB
dti-1351	256	3	mol	mol	ADP
dti-1351	256	4	cell	cell	NOUN
dti-1351	256	5	biol	biol	PROPN
dti-1351	256	6	2002;3:742–54	2002;3:742–54	NUM
dti-1351	256	7	.	.	PROPN
dti-1351	257	1	15	15	NUM
dti-1351	257	2	.	.	X
dti-1351	257	3	aepfelbacher	aepfelbacher	PROPN
dti-1351	257	4	m	m	PROPN
dti-1351	257	5	,	,	PUNCT
dti-1351	257	6	zumbihl	zumbihl	PROPN
dti-1351	257	7	r	r	X
dti-1351	257	8	,	,	PUNCT
dti-1351	257	9	heesemann	heesemann	NOUN
dti-1351	257	10	j.	j.	PROPN
dti-1351	257	11	modulation	modulation	NOUN
dti-1351	257	12	of	of	ADP
dti-1351	257	13	rho	rho	ADJ
dti-1351	257	14	gtpases	gtpase	NOUN
dti-1351	257	15	and	and	CCONJ
dti-1351	257	16	the	the	DET
dti-1351	257	17	actin	actin	NOUN
dti-1351	257	18	cytoskeleton	cytoskeleton	NOUN
dti-1351	257	19	by	by	ADP
dti-1351	257	20	yopt	yopt	PROPN
dti-1351	257	21	of	of	ADP
dti-1351	257	22	yersinia	yersinia	NOUN
dti-1351	257	23	.	.	PUNCT
dti-1351	258	1	curr	curr	PROPN
dti-1351	258	2	top	top	PROPN
dti-1351	258	3	microbiol	microbiol	PROPN
dti-1351	258	4	immunol	immunol	NOUN
dti-1351	258	5	.	.	PUNCT
dti-1351	259	1	2005;291	2005;291	NUM
dti-1351	259	2	:	:	PUNCT
dti-1351	260	1	167–75	167–75	X
dti-1351	260	2	.	.	X
dti-1351	260	3	16	16	NUM
dti-1351	260	4	.	.	PUNCT
dti-1351	261	1	iriarte	iriarte	NOUN
dti-1351	261	2	m	m	PROPN
dti-1351	261	3	,	,	PUNCT
dti-1351	261	4	cornelis	cornelis	PROPN
dti-1351	261	5	gr	gr	PROPN
dti-1351	261	6	.	.	PROPN
dti-1351	261	7	yopt	yopt	PROPN
dti-1351	261	8	,	,	PUNCT
dti-1351	261	9	a	a	DET
dti-1351	261	10	new	new	ADJ
dti-1351	261	11	yersinia	yersinia	NOUN
dti-1351	261	12	yop	yop	PROPN
dti-1351	261	13	effector	effector	NOUN
dti-1351	261	14	protein	protein	NOUN
dti-1351	261	15	,	,	PUNCT
dti-1351	261	16	affects	affect	VERB
dti-1351	261	17	the	the	DET
dti-1351	261	18	cytoskeleton	cytoskeleton	NOUN
dti-1351	261	19	of	of	ADP
dti-1351	261	20	host	host	NOUN
dti-1351	261	21	cells	cell	NOUN
dti-1351	261	22	.	.	PUNCT
dti-1351	262	1	mol	mol	ADP
dti-1351	262	2	microbiol	microbiol	PROPN
dti-1351	262	3	.	.	PUNCT
dti-1351	263	1	1998;9:915–29	1998;9:915–29	X
dti-1351	263	2	.	.	PUNCT
dti-1351	264	1	17	17	NUM
dti-1351	264	2	.	.	PUNCT
dti-1351	264	3	green	green	PROPN
dti-1351	264	4	sp	sp	PROPN
dti-1351	264	5	,	,	PUNCT
dti-1351	264	6	hartland	hartland	PROPN
dti-1351	264	7	el	el	PROPN
dti-1351	264	8	,	,	PUNCT
dti-1351	264	9	robins­browne	robins­browne	PROPN
dti-1351	264	10	rm	rm	PROPN
dti-1351	264	11	,	,	PUNCT
dti-1351	264	12	phillips	phillips	PROPN
dti-1351	264	13	wa	wa	PROPN
dti-1351	264	14	.	.	PROPN
dti-1351	265	1	role	role	NOUN
dti-1351	265	2	of	of	ADP
dti-1351	265	3	yoph	yoph	NOUN
dti-1351	265	4	in	in	ADP
dti-1351	265	5	the	the	DET
dti-1351	265	6	suppression	suppression	NOUN
dti-1351	265	7	of	of	ADP
dti-1351	265	8	tyrosine	tyrosine	NOUN
dti-1351	265	9	phosphorylation	phosphorylation	NOUN
dti-1351	265	10	and	and	CCONJ
dti-1351	265	11	respiratory	respiratory	ADJ
dti-1351	265	12	burst	burst	ADJ
dti-1351	265	13	activity	activity	NOUN
dti-1351	265	14	in	in	ADP
dti-1351	265	15	murine	murine	ADJ
dti-1351	265	16	macrophages	macrophage	NOUN
dti-1351	265	17	infected	infect	VERB
dti-1351	265	18	with	with	ADP
dti-1351	265	19	yersinia	yersinia	PROPN
dti-1351	265	20	enterocolitica	enterocolitica	PROPN
dti-1351	265	21	.	.	PUNCT
dti-1351	266	1	j	j	PROPN
dti-1351	266	2	leukoc	leukoc	VERB
dti-1351	266	3	biol	biol	PROPN
dti-1351	266	4	.	.	PUNCT
dti-1351	267	1	1995;57	1995;57	NUM
dti-1351	267	2	:	:	PUNCT
dti-1351	268	1	972–7	972–7	NOUN
dti-1351	268	2	.	.	PUNCT
dti-1351	268	3	18	18	NUM
dti-1351	268	4	.	.	PUNCT
dti-1351	269	1	shao	shao	PROPN
dti-1351	269	2	f	f	PROPN
dti-1351	269	3	,	,	PUNCT
dti-1351	269	4	dixon	dixon	PROPN
dti-1351	269	5	je	je	PROPN
dti-1351	269	6	.	.	PUNCT
dti-1351	270	1	yopt	yopt	PROPN
dti-1351	270	2	is	be	AUX
dti-1351	270	3	a	a	DET
dti-1351	270	4	cysteine	cysteine	NOUN
dti-1351	270	5	protease	protease	NOUN
dti-1351	270	6	cleaving	cleave	VERB
dti-1351	270	7	rho	rho	ADJ
dti-1351	270	8	family	family	NOUN
dti-1351	270	9	gtpases	gtpase	NOUN
dti-1351	270	10	.	.	PUNCT
dti-1351	271	1	adv	adv	PROPN
dti-1351	271	2	exp	exp	NUM
dti-1351	271	3	med	med	ADJ
dti-1351	271	4	biol	biol	NOUN
dti-1351	271	5	.	.	PUNCT
dti-1351	272	1	2003;529:79–84	2003;529:79–84	NUM
dti-1351	272	2	.	.	NOUN
dti-1351	272	3	19	19	NUM
dti-1351	272	4	.	.	PUNCT
dti-1351	273	1	shao	shao	PROPN
dti-1351	273	2	f	f	PROPN
dti-1351	273	3	,	,	PUNCT
dti-1351	273	4	merritt	merritt	PROPN
dti-1351	273	5	pm	pm	PROPN
dti-1351	273	6	,	,	PUNCT
dti-1351	273	7	bao	bao	PROPN
dti-1351	273	8	z	z	PROPN
dti-1351	273	9	,	,	PUNCT
dti-1351	273	10	innes	innes	PROPN
dti-1351	273	11	rw	rw	PROPN
dti-1351	273	12	,	,	PUNCT
dti-1351	273	13	dixon	dixon	PROPN
dti-1351	273	14	je	je	PROPN
dti-1351	273	15	.	.	PUNCT
dti-1351	274	1	a	a	DET
dti-1351	274	2	yersinia	yersinia	NOUN
dti-1351	274	3	effector	effector	NOUN
dti-1351	274	4	and	and	CCONJ
dti-1351	274	5	a	a	DET
dti-1351	274	6	pseudomonas	pseudomona	NOUN
dti-1351	274	7	avirulence	avirulence	NOUN
dti-1351	274	8	protein	protein	NOUN
dti-1351	274	9	define	define	VERB
dti-1351	274	10	a	a	DET
dti-1351	274	11	family	family	NOUN
dti-1351	274	12	of	of	ADP
dti-1351	274	13	cysteine	cysteine	NOUN
dti-1351	274	14	proteases	protease	NOUN
dti-1351	274	15	functioning	function	VERB
dti-1351	274	16	in	in	ADP
dti-1351	274	17	bacterial	bacterial	ADJ
dti-1351	274	18	pathogenesis	pathogenesis	NOUN
dti-1351	274	19	.	.	PUNCT
dti-1351	275	1	cell	cell	NOUN
dti-1351	275	2	.	.	PUNCT
dti-1351	276	1	2002;109:575–88	2002;109:575–88	NOUN
dti-1351	276	2	.	.	PUNCT
dti-1351	277	1	20	20	NUM
dti-1351	277	2	.	.	PUNCT
dti-1351	278	1	sorg	sorg	PROPN
dti-1351	278	2	i	i	PROPN
dti-1351	278	3	,	,	PUNCT
dti-1351	278	4	goehring	goehre	VERB
dti-1351	278	5	um	um	INTJ
dti-1351	278	6	,	,	PUNCT
dti-1351	278	7	aktories	aktorie	VERB
dti-1351	278	8	k	k	PROPN
dti-1351	278	9	,	,	PUNCT
dti-1351	278	10	schmidt	schmidt	PROPN
dti-1351	278	11	g.	g.	PROPN
dti-1351	278	12	recombinant	recombinant	PROPN
dti-1351	278	13	yersinia	yersinia	PROPN
dti-1351	278	14	yopt	yopt	PROPN
dti-1351	278	15	leads	lead	VERB
dti-1351	278	16	to	to	ADP
dti-1351	278	17	uncoupling	uncouple	VERB
dti-1351	278	18	of	of	ADP
dti-1351	278	19	rhoa­effector	rhoa­effector	NOUN
dti-1351	278	20	interaction	interaction	NOUN
dti-1351	278	21	.	.	PUNCT
dti-1351	279	1	infect	infect	VERB
dti-1351	279	2	immun	immun	PROPN
dti-1351	279	3	.	.	PUNCT
dti-1351	280	1	2001;69:7535–43	2001;69:7535–43	NUM
dti-1351	280	2	.	.	PUNCT
dti-1351	281	1	21	21	NUM
dti-1351	281	2	.	.	PUNCT
dti-1351	282	1	zhang	zhang	PROPN
dti-1351	282	2	fl	fl	PROPN
dti-1351	282	3	,	,	PUNCT
dti-1351	282	4	casey	casey	PROPN
dti-1351	282	5	pj	pj	PROPN
dti-1351	282	6	.	.	PUNCT
dti-1351	283	1	protein	protein	NOUN
dti-1351	283	2	prenylation	prenylation	NOUN
dti-1351	283	3	:	:	PUNCT
dti-1351	283	4	molecular	molecular	ADJ
dti-1351	283	5	mechanisms	mechanism	NOUN
dti-1351	283	6	and	and	CCONJ
dti-1351	283	7	functional	functional	ADJ
dti-1351	283	8	consequences	consequence	NOUN
dti-1351	283	9	.	.	PUNCT
dti-1351	284	1	annu	annu	PROPN
dti-1351	284	2	rev	rev	VERB
dti-1351	284	3	biochem	biochem	PROPN
dti-1351	284	4	.	.	PUNCT
dti-1351	285	1	1996;65:241–69	1996;65:241–69	X
dti-1351	285	2	.	.	PUNCT
dti-1351	286	1	22	22	NUM
dti-1351	286	2	.	.	PUNCT
dti-1351	287	1	linding	linde	VERB
dti-1351	287	2	r	r	NOUN
dti-1351	287	3	,	,	PUNCT
dti-1351	287	4	russell	russell	PROPN
dti-1351	287	5	rb	rb	PROPN
dti-1351	287	6	,	,	PUNCT
dti-1351	287	7	neduva	neduva	PROPN
dti-1351	287	8	v	v	NOUN
dti-1351	287	9	,	,	PUNCT
dti-1351	287	10	gibson	gibson	PROPN
dti-1351	287	11	tj	tj	PROPN
dti-1351	287	12	.	.	PROPN
dti-1351	287	13	globplot	globplot	PROPN
dti-1351	287	14	:	:	PUNCT
dti-1351	287	15	exploring	explore	VERB
dti-1351	287	16	protein	protein	NOUN
dti-1351	287	17	sequences	sequence	NOUN
dti-1351	287	18	for	for	ADP
dti-1351	287	19	globularity	globularity	NOUN
dti-1351	287	20	and	and	CCONJ
dti-1351	287	21	disorder	disorder	NOUN
dti-1351	287	22	.	.	PUNCT
dti-1351	288	1	nucleic	nucleic	ADJ
dti-1351	288	2	acids	acid	NOUN
dti-1351	288	3	res	re	NOUN
dti-1351	288	4	.	.	PUNCT
dti-1351	289	1	2003;31:3701–08	2003;31:3701–08	NUM
dti-1351	289	2	.	.	PUNCT
dti-1351	290	1	23	23	NUM
dti-1351	290	2	.	.	PUNCT
dti-1351	291	1	plake	plake	NOUN
dti-1351	291	2	c	c	PROPN
dti-1351	291	3	,	,	PUNCT
dti-1351	291	4	schiemann	schiemann	PROPN
dti-1351	291	5	t	t	PROPN
dti-1351	291	6	,	,	PUNCT
dti-1351	291	7	pankalla	pankalla	NOUN
dti-1351	291	8	m	m	PROPN
dti-1351	291	9	,	,	PUNCT
dti-1351	291	10	hakenberg	hakenberg	PROPN
dti-1351	291	11	j	j	PROPN
dti-1351	291	12	,	,	PUNCT
dti-1351	291	13	leser	leser	PROPN
dti-1351	291	14	u.	u.	PROPN
dti-1351	291	15	alibaba	alibaba	PROPN
dti-1351	291	16	:	:	PUNCT
dti-1351	291	17	pubmed	pubmed	VERB
dti-1351	291	18	as	as	ADP
dti-1351	291	19	a	a	DET
dti-1351	291	20	graph	graph	NOUN
dti-1351	291	21	.	.	PUNCT
dti-1351	292	1	bioinformatics	bioinformatics	NOUN
dti-1351	292	2	.	.	PUNCT
dti-1351	293	1	2007;22:2444–45	2007;22:2444–45	NUM
dti-1351	293	2	.	.	X
dti-1351	294	1	24	24	NUM
dti-1351	294	2	.	.	PUNCT
dti-1351	295	1	franceschini	franceschini	PROPN
dti-1351	295	2	a	a	PRON
dti-1351	295	3	,	,	PUNCT
dti-1351	295	4	szklarczyk	szklarczyk	ADJ
dti-1351	295	5	d	d	NOUN
dti-1351	295	6	,	,	PUNCT
dti-1351	295	7	frankild	frankild	PROPN
dti-1351	295	8	s	s	PROPN
dti-1351	295	9	,	,	PUNCT
dti-1351	295	10	et	et	PROPN
dti-1351	295	11	al	al	PROPN
dti-1351	295	12	.	.	PROPN
dti-1351	295	13	string	string	PROPN
dti-1351	296	1	v9.1	v9.1	NOUN
dti-1351	296	2	:	:	PUNCT
dti-1351	296	3	protein­protein	protein­protein	ADJ
dti-1351	296	4	interaction	interaction	NOUN
dti-1351	296	5	networks	network	NOUN
dti-1351	296	6	,	,	PUNCT
dti-1351	296	7	with	with	ADP
dti-1351	296	8	increased	increase	VERB
dti-1351	296	9	coverage	coverage	NOUN
dti-1351	296	10	and	and	CCONJ
dti-1351	296	11	integration	integration	NOUN
dti-1351	296	12	.	.	PUNCT
dti-1351	297	1	nucleic	nucleic	ADJ
dti-1351	297	2	acids	acid	NOUN
dti-1351	297	3	res	re	NOUN
dti-1351	297	4	.	.	PUNCT
dti-1351	298	1	2013;41:808–15	2013;41:808–15	X
dti-1351	298	2	.	.	PROPN
dti-1351	298	3	25	25	NUM
dti-1351	298	4	.	.	PUNCT
dti-1351	298	5	kelley	kelley	PROPN
dti-1351	298	6	la	la	PROPN
dti-1351	298	7	,	,	PUNCT
dti-1351	298	8	sternberg	sternberg	PROPN
dti-1351	298	9	mj	mj	PROPN
dti-1351	298	10	.	.	PUNCT
dti-1351	298	11	protein	protein	NOUN
dti-1351	298	12	structure	structure	NOUN
dti-1351	298	13	prediction	prediction	NOUN
dti-1351	298	14	on	on	ADP
dti-1351	298	15	the	the	DET
dti-1351	298	16	web	web	NOUN
dti-1351	298	17	:	:	PUNCT
dti-1351	298	18	a	a	DET
dti-1351	298	19	case	case	NOUN
dti-1351	298	20	study	study	NOUN
dti-1351	298	21	using	use	VERB
dti-1351	298	22	the	the	DET
dti-1351	298	23	phyre	phyre	PROPN
dti-1351	298	24	server	server	NOUN
dti-1351	298	25	.	.	PUNCT
dti-1351	299	1	nat	nat	PROPN
dti-1351	299	2	protoc	protoc	NOUN
dti-1351	299	3	.	.	PUNCT
dti-1351	300	1	2009;4:363–71	2009;4:363–71	NOUN
dti-1351	300	2	.	.	PROPN
dti-1351	301	1	26	26	NUM
dti-1351	301	2	.	.	PUNCT
dti-1351	302	1	xu	xu	PROPN
dti-1351	303	1	d	d	PROPN
dti-1351	303	2	,	,	PUNCT
dti-1351	303	3	zhang	zhang	PROPN
dti-1351	303	4	y.	y.	PROPN
dti-1351	303	5	improving	improve	VERB
dti-1351	303	6	the	the	DET
dti-1351	303	7	physical	physical	ADJ
dti-1351	303	8	realism	realism	NOUN
dti-1351	303	9	and	and	CCONJ
dti-1351	303	10	structural	structural	ADJ
dti-1351	303	11	accuracy	accuracy	NOUN
dti-1351	303	12	of	of	ADP
dti-1351	303	13	protein	protein	NOUN
dti-1351	303	14	models	model	NOUN
dti-1351	303	15	by	by	ADP
dti-1351	303	16	a	a	DET
dti-1351	303	17	two­step	two­step	ADJ
dti-1351	303	18	atomic­level	atomic­level	NOUN
dti-1351	303	19	energy	energy	NOUN
dti-1351	303	20	minimization	minimization	NOUN
dti-1351	303	21	.	.	PUNCT
dti-1351	304	1	biophys	biophys	PROPN
dti-1351	304	2	j.	j.	PROPN
dti-1351	304	3	2011;101:2525–34	2011;101:2525–34	PROPN
dti-1351	304	4	.	.	PROPN
dti-1351	305	1	27	27	NUM
dti-1351	305	2	.	.	PUNCT
dti-1351	306	1	laskowski	laskowski	PROPN
dti-1351	306	2	ra	ra	PROPN
dti-1351	306	3	,	,	PUNCT
dti-1351	306	4	rullmannn	rullmannn	VERB
dti-1351	306	5	ja	ja	PROPN
dti-1351	306	6	,	,	PUNCT
dti-1351	306	7	macarthur	macarthur	PROPN
dti-1351	306	8	mw	mw	PROPN
dti-1351	306	9	,	,	PUNCT
dti-1351	306	10	kaptein	kaptein	PROPN
dti-1351	306	11	r	r	NOUN
dti-1351	306	12	,	,	PUNCT
dti-1351	306	13	thornton	thornton	PROPN
dti-1351	306	14	jm	jm	PROPN
dti-1351	306	15	.	.	PROPN
dti-1351	306	16	aqua	aqua	PROPN
dti-1351	306	17	and	and	CCONJ
dti-1351	306	18	procheck­nmr	procheck­nmr	ADJ
dti-1351	306	19	:	:	PUNCT
dti-1351	306	20	programs	program	NOUN
dti-1351	306	21	for	for	ADP
dti-1351	306	22	checking	check	VERB
dti-1351	306	23	the	the	DET
dti-1351	306	24	quality	quality	NOUN
dti-1351	306	25	of	of	ADP
dti-1351	306	26	protein	protein	NOUN
dti-1351	306	27	structures	structure	NOUN
dti-1351	306	28	solved	solve	VERB
dti-1351	306	29	by	by	ADP
dti-1351	306	30	nmr	nmr	NOUN
dti-1351	306	31	.	.	PUNCT
dti-1351	307	1	j	j	PROPN
dti-1351	307	2	biomol	biomol	PROPN
dti-1351	307	3	nmr	nmr	PROPN
dti-1351	307	4	.	.	PUNCT
dti-1351	308	1	1996;8:477–86	1996;8:477–86	NUM
dti-1351	308	2	.	.	PUNCT
dti-1351	309	1	28	28	NUM
dti-1351	309	2	.	.	PUNCT
dti-1351	310	1	ramachandran	ramachandran	PROPN
dti-1351	310	2	gn	gn	PROPN
dti-1351	310	3	,	,	PUNCT
dti-1351	310	4	ramakrishnan	ramakrishnan	PROPN
dti-1351	310	5	c	c	PROPN
dti-1351	310	6	,	,	PUNCT
dti-1351	310	7	sasisekharan	sasisekharan	VERB
dti-1351	310	8	v.	v.	ADP
dti-1351	310	9	stereochemistry	stereochemistry	NOUN
dti-1351	310	10	of	of	ADP
dti-1351	310	11	poly­	poly­	PROPN
dti-1351	310	12	peptide	peptide	ADJ
dti-1351	310	13	chain	chain	NOUN
dti-1351	310	14	configurations	configuration	NOUN
dti-1351	310	15	.	.	PUNCT
dti-1351	311	1	j	j	PROPN
dti-1351	311	2	mol	mol	ADP
dti-1351	311	3	biol	biol	PROPN
dti-1351	311	4	.	.	PUNCT
dti-1351	312	1	1963;7:95–9	1963;7:95–9	NOUN
dti-1351	312	2	.	.	PUNCT
dti-1351	313	1	29	29	NUM
dti-1351	313	2	.	.	PUNCT
dti-1351	314	1	eisenberg	eisenberg	PROPN
dti-1351	314	2	d	d	PROPN
dti-1351	314	3	,	,	PUNCT
dti-1351	314	4	lüthy	lüthy	ADJ
dti-1351	314	5	r	r	NOUN
dti-1351	314	6	,	,	PUNCT
dti-1351	314	7	bowie	bowie	PROPN
dti-1351	314	8	ju	ju	PROPN
dti-1351	314	9	.	.	PUNCT
dti-1351	315	1	verify3d	verify3d	NOUN
dti-1351	315	2	:	:	PUNCT
dti-1351	315	3	assessment	assessment	NOUN
dti-1351	315	4	of	of	ADP
dti-1351	315	5	protein	protein	NOUN
dti-1351	315	6	models	model	NOUN
dti-1351	315	7	with	with	ADP
dti-1351	315	8	three­dimensional	three­dimensional	ADJ
dti-1351	315	9	profiles	profile	NOUN
dti-1351	315	10	.	.	PUNCT
dti-1351	316	1	methods	method	NOUN
dti-1351	316	2	enzymol	enzymol	PROPN
dti-1351	316	3	.	.	PUNCT
dti-1351	317	1	1997;277:396–404	1997;277:396–404	NUM
dti-1351	317	2	.	.	PUNCT
dti-1351	318	1	http://www.la-press.com	http://www.la-press.com	X
dti-1351	319	1	molecular	molecular	ADJ
dti-1351	319	2	characterization	characterization	NOUN
dti-1351	319	3	of	of	ADP
dti-1351	319	4	cysteine	cysteine	NOUN
dti-1351	319	5	protease	protease	NOUN
dti-1351	319	6	yopt	yopt	NOUN
dti-1351	319	7	9drug	9drug	NUM
dti-1351	319	8	target	target	NOUN
dti-1351	319	9	insights	insight	NOUN
dti-1351	319	10	2014:8	2014:8	NUM
dti-1351	319	11	30	30	NUM
dti-1351	319	12	.	.	PUNCT
dti-1351	320	1	colovos	colovos	PROPN
dti-1351	321	1	c	c	X
dti-1351	321	2	,	,	PUNCT
dti-1351	321	3	yeates	yeate	NOUN
dti-1351	321	4	to	to	ADP
dti-1351	321	5	.	.	PUNCT
dti-1351	322	1	verification	verification	NOUN
dti-1351	322	2	of	of	ADP
dti-1351	322	3	protein	protein	NOUN
dti-1351	322	4	structures	structure	NOUN
dti-1351	322	5	:	:	PUNCT
dti-1351	322	6	patterns	pattern	NOUN
dti-1351	322	7	of	of	ADP
dti-1351	322	8	nonbonded	nonbonde	VERB
dti-1351	322	9	atomic	atomic	ADJ
dti-1351	322	10	interactions	interaction	NOUN
dti-1351	322	11	.	.	PUNCT
dti-1351	323	1	protein	protein	NOUN
dti-1351	323	2	sciences	science	NOUN
dti-1351	323	3	.	.	PUNCT
dti-1351	324	1	1993;2:1511–19	1993;2:1511–19	NUM
dti-1351	324	2	.	.	PUNCT
dti-1351	325	1	31	31	NUM
dti-1351	325	2	.	.	PUNCT
dti-1351	326	1	guex	guex	PROPN
dti-1351	326	2	n	n	CCONJ
dti-1351	326	3	,	,	PUNCT
dti-1351	326	4	peitsch	peitsch	PROPN
dti-1351	326	5	mc	mc	PROPN
dti-1351	326	6	.	.	PROPN
dti-1351	326	7	swiss­model	swiss­model	PROPN
dti-1351	326	8	and	and	CCONJ
dti-1351	326	9	the	the	DET
dti-1351	326	10	swiss­pdbviewer	swiss­pdbviewer	NOUN
dti-1351	326	11	:	:	PUNCT
dti-1351	326	12	an	an	DET
dti-1351	326	13	environ­	environ­	X
dti-1351	326	14	ment	ment	NOUN
dti-1351	326	15	for	for	ADP
dti-1351	326	16	comparative	comparative	ADJ
dti-1351	326	17	protein	protein	NOUN
dti-1351	326	18	modeling	modeling	NOUN
dti-1351	326	19	.	.	PUNCT
dti-1351	327	1	electrophoresis.1997;18:2714–23	electrophoresis.1997;18:2714–23	PROPN
dti-1351	327	2	.	.	PROPN
dti-1351	327	3	32	32	NUM
dti-1351	327	4	.	.	PUNCT
dti-1351	328	1	geourjon	geourjon	NOUN
dti-1351	328	2	c	c	NOUN
dti-1351	328	3	,	,	PUNCT
dti-1351	328	4	deléage	deléage	NOUN
dti-1351	328	5	g.	g.	PROPN
dti-1351	328	6	sopma	sopma	PROPN
dti-1351	328	7	:	:	PUNCT
dti-1351	328	8	significant	significant	ADJ
dti-1351	328	9	improvements	improvement	NOUN
dti-1351	328	10	in	in	ADP
dti-1351	328	11	protein	protein	NOUN
dti-1351	328	12	secondary	secondary	ADJ
dti-1351	328	13	structure	structure	NOUN
dti-1351	328	14	prediction	prediction	NOUN
dti-1351	328	15	by	by	ADP
dti-1351	328	16	consensus	consensus	NOUN
dti-1351	328	17	prediction	prediction	NOUN
dti-1351	328	18	from	from	ADP
dti-1351	328	19	multiple	multiple	ADJ
dti-1351	328	20	alignments	alignment	NOUN
dti-1351	328	21	.	.	PUNCT
dti-1351	329	1	comput	comput	PROPN
dti-1351	329	2	appl	appl	PROPN
dti-1351	329	3	biosci	biosci	PROPN
dti-1351	329	4	.	.	PUNCT
dti-1351	330	1	1995;11:681–4	1995;11:681–4	NUM
dti-1351	330	2	.	.	PUNCT
dti-1351	331	1	33	33	NUM
dti-1351	331	2	.	.	PUNCT
dti-1351	332	1	dundas	dundas	PROPN
dti-1351	332	2	j	j	PROPN
dti-1351	332	3	,	,	PUNCT
dti-1351	332	4	ouyang	ouyang	PROPN
dti-1351	332	5	z	z	PROPN
dti-1351	332	6	,	,	PUNCT
dti-1351	332	7	tseng	tseng	PROPN
dti-1351	332	8	j	j	PROPN
dti-1351	332	9	,	,	PUNCT
dti-1351	332	10	binkowski	binkowski	VERB
dti-1351	332	11	a	a	PRON
dti-1351	332	12	,	,	PUNCT
dti-1351	332	13	turpaz	turpaz	PROPN
dti-1351	332	14	y	y	PROPN
dti-1351	332	15	,	,	PUNCT
dti-1351	332	16	liang	liang	PROPN
dti-1351	332	17	j.	j.	PROPN
dti-1351	332	18	castp	castp	PROPN
dti-1351	332	19	:	:	PUNCT
dti-1351	332	20	com­	com­	PROPN
dti-1351	332	21	puted	put	VERB
dti-1351	332	22	atlas	atlas	PROPN
dti-1351	332	23	of	of	ADP
dti-1351	332	24	surface	surface	NOUN
dti-1351	332	25	topography	topography	NOUN
dti-1351	332	26	of	of	ADP
dti-1351	332	27	proteins	protein	NOUN
dti-1351	332	28	with	with	ADP
dti-1351	332	29	structural	structural	ADJ
dti-1351	332	30	and	and	CCONJ
dti-1351	332	31	topographical	topographical	ADJ
dti-1351	332	32	mapping	mapping	NOUN
dti-1351	332	33	of	of	ADP
dti-1351	332	34	functionally	functionally	ADV
dti-1351	332	35	annotated	annotate	VERB
dti-1351	332	36	residues	residue	NOUN
dti-1351	332	37	.	.	PUNCT
dti-1351	333	1	nucleic	nucleic	ADJ
dti-1351	333	2	acids	acid	NOUN
dti-1351	333	3	res	re	NOUN
dti-1351	333	4	.	.	PUNCT
dti-1351	334	1	2006;34:116–8	2006;34:116–8	NUM
dti-1351	334	2	.	.	PUNCT
dti-1351	335	1	34	34	NUM
dti-1351	335	2	.	.	PUNCT
dti-1351	336	1	schneider	schneider	PROPN
dti-1351	336	2	m	m	PROPN
dti-1351	336	3	,	,	PUNCT
dti-1351	336	4	uniprot	uniprot	ADJ
dti-1351	336	5	consortium	consortium	NOUN
dti-1351	336	6	,	,	PUNCT
dti-1351	336	7	poux	poux	NOUN
dti-1351	336	8	s.	s.	PROPN
dti-1351	336	9	uniprotkb	uniprotkb	PROPN
dti-1351	336	10	amid	amid	ADP
dti-1351	336	11	the	the	DET
dti-1351	336	12	turmoil	turmoil	NOUN
dti-1351	336	13	of	of	ADP
dti-1351	336	14	plant	plant	NOUN
dti-1351	336	15	proteomics	proteomic	NOUN
dti-1351	336	16	research	research	NOUN
dti-1351	336	17	.	.	PUNCT
dti-1351	337	1	front	front	ADJ
dti-1351	337	2	plant	plant	NOUN
dti-1351	337	3	sci	sci	PROPN
dti-1351	337	4	.	.	PUNCT
dti-1351	338	1	2012;3:270–7	2012;3:270–7	PROPN
dti-1351	338	2	.	.	PUNCT
dti-1351	339	1	35	35	NUM
dti-1351	339	2	.	.	PUNCT
dti-1351	340	1	shoichet	shoichet	PROPN
dti-1351	340	2	bk	bk	PROPN
dti-1351	340	3	,	,	PUNCT
dti-1351	340	4	baase	baase	PROPN
dti-1351	340	5	wa	wa	PROPN
dti-1351	340	6	,	,	PUNCT
dti-1351	340	7	kuroki	kuroki	PROPN
dti-1351	340	8	r	r	PROPN
dti-1351	340	9	,	,	PUNCT
dti-1351	340	10	matthews	matthews	PROPN
dti-1351	340	11	bw	bw	PROPN
dti-1351	340	12	.	.	PUNCT
dti-1351	341	1	a	a	DET
dti-1351	341	2	relationship	relationship	NOUN
dti-1351	341	3	between	between	ADP
dti-1351	341	4	pro­	pro­	PROPN
dti-1351	341	5	tein	tein	NOUN
dti-1351	341	6	stability	stability	NOUN
dti-1351	341	7	and	and	CCONJ
dti-1351	341	8	protein	protein	NOUN
dti-1351	341	9	function	function	NOUN
dti-1351	341	10	.	.	PUNCT
dti-1351	342	1	proc	proc	PROPN
dti-1351	342	2	natl	natl	PROPN
dti-1351	342	3	acad	acad	PROPN
dti-1351	342	4	sci	sci	PROPN
dti-1351	342	5	u	u	PROPN
dti-1351	342	6	s	s	PROPN
dti-1351	342	7	a.	a.	NOUN
dti-1351	342	8	1995;92:452–6	1995;92:452–6	NUM
dti-1351	342	9	.	.	PUNCT
dti-1351	343	1	36	36	NUM
dti-1351	343	2	.	.	PUNCT
dti-1351	344	1	dobson	dobson	PROPN
dti-1351	344	2	pd	pd	PROPN
dti-1351	344	3	,	,	PUNCT
dti-1351	344	4	cai	cai	PROPN
dti-1351	344	5	yd	yd	PROPN
dti-1351	344	6	,	,	PUNCT
dti-1351	344	7	stapley	stapley	ADJ
dti-1351	344	8	bj	bj	VERB
dti-1351	344	9	,	,	PUNCT
dti-1351	344	10	doig	doig	PROPN
dti-1351	344	11	aj	aj	PROPN
dti-1351	344	12	.	.	PROPN
dti-1351	344	13	prediction	prediction	NOUN
dti-1351	344	14	of	of	ADP
dti-1351	344	15	protein	protein	NOUN
dti-1351	344	16	function	function	NOUN
dti-1351	344	17	in	in	ADP
dti-1351	344	18	the	the	DET
dti-1351	344	19	absence	absence	NOUN
dti-1351	344	20	of	of	ADP
dti-1351	344	21	significant	significant	ADJ
dti-1351	344	22	sequence	sequence	NOUN
dti-1351	344	23	similarity	similarity	NOUN
dti-1351	344	24	.	.	PUNCT
dti-1351	345	1	curr	curr	PROPN
dti-1351	345	2	med	med	PROPN
dti-1351	345	3	chem	chem	NOUN
dti-1351	345	4	.	.	PUNCT
dti-1351	346	1	2004;11:2135–42	2004;11:2135–42	NUM
dti-1351	346	2	.	.	PUNCT
dti-1351	347	1	37	37	NUM
dti-1351	347	2	.	.	PUNCT
dti-1351	348	1	hawkins	hawkins	PROPN
dti-1351	348	2	t	t	PROPN
dti-1351	348	3	,	,	PUNCT
dti-1351	348	4	kihara	kihara	PROPN
dti-1351	348	5	d.	d.	PROPN
dti-1351	348	6	function	function	PROPN
dti-1351	348	7	prediction	prediction	NOUN
dti-1351	348	8	of	of	ADP
dti-1351	348	9	uncharacterized	uncharacterized	ADJ
dti-1351	348	10	proteins	protein	NOUN
dti-1351	348	11	.	.	PUNCT
dti-1351	349	1	journal	journal	NOUN
dti-1351	349	2	of	of	ADP
dti-1351	349	3	bioinformatics	bioinformatics	NOUN
dti-1351	349	4	and	and	CCONJ
dti-1351	349	5	computational	computational	ADJ
dti-1351	349	6	biology	biology	NOUN
dti-1351	349	7	.	.	PUNCT
dti-1351	350	1	2007;5:1–30	2007;5:1–30	X
dti-1351	350	2	.	.	PUNCT
dti-1351	351	1	38	38	NUM
dti-1351	351	2	.	.	PUNCT
dti-1351	352	1	wright	wright	PROPN
dti-1351	352	2	pe	pe	PROPN
dti-1351	352	3	,	,	PUNCT
dti-1351	352	4	dyson	dyson	PROPN
dti-1351	352	5	hj	hj	PROPN
dti-1351	352	6	.	.	PROPN
dti-1351	352	7	intrinsically	intrinsically	ADV
dti-1351	352	8	unstructured	unstructured	ADJ
dti-1351	352	9	proteins	protein	NOUN
dti-1351	352	10	:	:	PUNCT
dti-1351	352	11	re­assessing	re­assesse	VERB
dti-1351	352	12	the	the	DET
dti-1351	352	13	pro­	pro­	PROPN
dti-1351	352	14	tein	tein	NOUN
dti-1351	352	15	structure­function	structure­function	NOUN
dti-1351	352	16	paradigm	paradigm	NOUN
dti-1351	352	17	.	.	PUNCT
dti-1351	353	1	j	j	PROPN
dti-1351	353	2	mol	mol	ADP
dti-1351	353	3	biol	biol	PROPN
dti-1351	353	4	.	.	PUNCT
dti-1351	354	1	1999;293:321–31	1999;293:321–31	NOUN
dti-1351	354	2	.	.	NOUN
dti-1351	354	3	39	39	NUM
dti-1351	354	4	.	.	PUNCT
dti-1351	355	1	stein	stein	PROPN
dti-1351	355	2	l.	l.	PROPN
dti-1351	355	3	genome	genome	PROPN
dti-1351	355	4	annotation	annotation	NOUN
dti-1351	355	5	:	:	PUNCT
dti-1351	355	6	from	from	ADP
dti-1351	355	7	sequence	sequence	NOUN
dti-1351	355	8	to	to	ADP
dti-1351	355	9	biology	biology	NOUN
dti-1351	355	10	.	.	PUNCT
dti-1351	356	1	nat	nat	PROPN
dti-1351	356	2	rev	rev	PROPN
dti-1351	356	3	genet	genet	PROPN
dti-1351	356	4	.	.	PUNCT
dti-1351	357	1	2001;2:493–503	2001;2:493–503	NUM
dti-1351	357	2	.	.	PROPN
dti-1351	357	3	40	40	NUM
dti-1351	357	4	.	.	PUNCT
dti-1351	358	1	arifuzzaman	arifuzzaman	PROPN
dti-1351	358	2	m	m	PROPN
dti-1351	358	3	,	,	PUNCT
dti-1351	358	4	maeda	maeda	PROPN
dti-1351	358	5	m	m	PROPN
dti-1351	358	6	,	,	PUNCT
dti-1351	358	7	itoh	itoh	PROPN
dti-1351	358	8	a	a	X
dti-1351	358	9	,	,	PUNCT
dti-1351	358	10	et	et	PROPN
dti-1351	358	11	al	al	PROPN
dti-1351	358	12	.	.	PROPN
dti-1351	358	13	large­scale	large­scale	ADJ
dti-1351	358	14	identification	identification	NOUN
dti-1351	358	15	of	of	ADP
dti-1351	358	16	protein	protein	NOUN
dti-1351	358	17	–	–	PUNCT
dti-1351	358	18	protein	protein	NOUN
dti-1351	358	19	interaction	interaction	NOUN
dti-1351	358	20	of	of	ADP
dti-1351	358	21	escherichia	escherichia	NOUN
dti-1351	358	22	coli	coli	NOUN
dti-1351	358	23	k­12	k­12	PROPN
dti-1351	358	24	.	.	PUNCT
dti-1351	359	1	genome	genome	NOUN
dti-1351	359	2	res	re	NOUN
dti-1351	359	3	.	.	PUNCT
dti-1351	360	1	2006;16:686–91	2006;16:686–91	NUM
dti-1351	360	2	.	.	NOUN
dti-1351	360	3	41	41	NUM
dti-1351	360	4	.	.	PUNCT
dti-1351	361	1	szklarczyk	szklarczyk	PROPN
dti-1351	361	2	d	d	X
dti-1351	361	3	,	,	PUNCT
dti-1351	361	4	franceschini	franceschini	PROPN
dti-1351	361	5	a	a	PRON
dti-1351	361	6	,	,	PUNCT
dti-1351	361	7	kuhn	kuhn	PROPN
dti-1351	361	8	m	m	PROPN
dti-1351	361	9	,	,	PUNCT
dti-1351	361	10	et	et	PROPN
dti-1351	361	11	al	al	PROPN
dti-1351	361	12	.	.	PUNCT
dti-1351	362	1	the	the	DET
dti-1351	362	2	string	string	NOUN
dti-1351	362	3	database	database	NOUN
dti-1351	362	4	in	in	ADP
dti-1351	362	5	2011	2011	NUM
dti-1351	362	6	:	:	PUNCT
dti-1351	362	7	functional	functional	ADJ
dti-1351	362	8	interaction	interaction	NOUN
dti-1351	362	9	networks	network	NOUN
dti-1351	362	10	of	of	ADP
dti-1351	362	11	proteins	protein	NOUN
dti-1351	362	12	,	,	PUNCT
dti-1351	362	13	globally	globally	ADV
dti-1351	362	14	integrated	integrate	VERB
dti-1351	362	15	and	and	CCONJ
dti-1351	362	16	scored	score	VERB
dti-1351	362	17	.	.	PUNCT
dti-1351	363	1	nucleic	nucleic	ADJ
dti-1351	363	2	acids	acid	NOUN
dti-1351	363	3	res	re	NOUN
dti-1351	363	4	.	.	PUNCT
dti-1351	363	5	2011;39:561–8	2011;39:561–8	NUM
dti-1351	363	6	.	.	PUNCT
dti-1351	364	1	42	42	NUM
dti-1351	364	2	.	.	PUNCT
dti-1351	365	1	fidanova	fidanova	PROPN
dti-1351	365	2	s	s	PROPN
dti-1351	365	3	,	,	PUNCT
dti-1351	365	4	lirkov	lirkov	PROPN
dti-1351	365	5	i.	i.	PROPN
dti-1351	365	6	3d	3d	PROPN
dti-1351	365	7	protein	protein	NOUN
dti-1351	365	8	structure	structure	NOUN
dti-1351	365	9	prediction	prediction	NOUN
dti-1351	365	10	.	.	PUNCT
dti-1351	366	1	seria	seria	PROPN
dti-1351	366	2	matematica	matematica	PROPN
dti-1351	366	3	-	-	PROPN
dti-1351	366	4	informatica	informatica	PROPN
dti-1351	366	5	.	.	PUNCT
dti-1351	367	1	2009;xlvii:33–46	2009;xlvii:33–46	NUM
dti-1351	367	2	.	.	PUNCT
dti-1351	368	1	43	43	NUM
dti-1351	368	2	.	.	PUNCT
dti-1351	369	1	kelley	kelley	PROPN
dti-1351	369	2	la	la	PROPN
dti-1351	369	3	,	,	PUNCT
dti-1351	369	4	sternberg	sternberg	PROPN
dti-1351	369	5	mje	mje	PROPN
dti-1351	369	6	.	.	PUNCT
dti-1351	370	1	protein	protein	NOUN
dti-1351	370	2	structure	structure	NOUN
dti-1351	370	3	prediction	prediction	NOUN
dti-1351	370	4	on	on	ADP
dti-1351	370	5	the	the	DET
dti-1351	370	6	web	web	NOUN
dti-1351	370	7	:	:	PUNCT
dti-1351	370	8	a	a	DET
dti-1351	370	9	case	case	NOUN
dti-1351	370	10	study	study	NOUN
dti-1351	370	11	using	use	VERB
dti-1351	370	12	the	the	DET
dti-1351	370	13	phyre	phyre	PROPN
dti-1351	370	14	server	server	NOUN
dti-1351	370	15	.	.	PUNCT
dti-1351	371	1	nat	nat	PROPN
dti-1351	371	2	protoc	protoc	NOUN
dti-1351	371	3	.	.	PUNCT
dti-1351	372	1	2009;4:363–71	2009;4:363–71	NOUN
dti-1351	372	2	.	.	PROPN
dti-1351	373	1	44	44	NUM
dti-1351	373	2	.	.	PUNCT
dti-1351	374	1	laurie	laurie	PROPN
dti-1351	374	2	at	at	ADP
dti-1351	374	3	,	,	PUNCT
dti-1351	374	4	jackson	jackson	PROPN
dti-1351	374	5	rm	rm	PROPN
dti-1351	374	6	.	.	PUNCT
dti-1351	375	1	methods	method	NOUN
dti-1351	375	2	for	for	ADP
dti-1351	375	3	the	the	DET
dti-1351	375	4	prediction	prediction	NOUN
dti-1351	375	5	of	of	ADP
dti-1351	375	6	protein­ligand	protein­ligand	ADJ
dti-1351	375	7	binding	bind	VERB
dti-1351	375	8	sites	site	NOUN
dti-1351	375	9	for	for	ADP
dti-1351	375	10	structure­based	structure­based	ADJ
dti-1351	375	11	drug	drug	NOUN
dti-1351	375	12	design	design	NOUN
dti-1351	375	13	and	and	CCONJ
dti-1351	375	14	virtual	virtual	ADJ
dti-1351	375	15	ligand	ligand	NOUN
dti-1351	375	16	screening	screening	NOUN
dti-1351	375	17	.	.	PUNCT
dti-1351	376	1	curr	curr	PROPN
dti-1351	376	2	protein	protein	PROPN
dti-1351	376	3	pept	pept	PROPN
dti-1351	376	4	sci	sci	PROPN
dti-1351	376	5	.	.	PUNCT
dti-1351	377	1	2006;7:395–406	2006;7:395–406	NUM
dti-1351	377	2	.	.	PROPN
dti-1351	377	3	45	45	NUM
dti-1351	377	4	.	.	PUNCT
dti-1351	378	1	jagielska	jagielska	PROPN
dti-1351	378	2	a	a	PRON
dti-1351	378	3	,	,	PUNCT
dti-1351	378	4	wroblewska	wroblewska	PROPN
dti-1351	378	5	l	l	PROPN
dti-1351	378	6	,	,	PUNCT
dti-1351	378	7	skolnick	skolnick	PROPN
dti-1351	378	8	j.	j.	PROPN
dti-1351	378	9	protein	protein	PROPN
dti-1351	378	10	model	model	PROPN
dti-1351	378	11	refinement	refinement	NOUN
dti-1351	378	12	using	use	VERB
dti-1351	378	13	an	an	DET
dti-1351	378	14	opti­	opti­	NOUN
dti-1351	378	15	mized	mize	VERB
dti-1351	378	16	physics­based	physics­base	VERB
dti-1351	378	17	all­atom	all­atom	PROPN
dti-1351	378	18	force	force	NOUN
dti-1351	378	19	field	field	NOUN
dti-1351	378	20	.	.	PUNCT
dti-1351	379	1	proc	proc	PROPN
dti-1351	379	2	natl	natl	PROPN
dti-1351	379	3	acad	acad	PROPN
dti-1351	379	4	sci	sci	PROPN
dti-1351	379	5	u	u	PROPN
dti-1351	379	6	s	s	NOUN
dti-1351	379	7	a.	a.	NOUN
dti-1351	379	8	2008;105	2008;105	NUM
dti-1351	379	9	:	:	PUNCT
dti-1351	380	1	8268–73	8268–73	NUM
dti-1351	380	2	.	.	PUNCT
dti-1351	381	1	46	46	NUM
dti-1351	381	2	.	.	PUNCT
dti-1351	382	1	ko	ko	PROPN
dti-1351	382	2	j	j	PROPN
dti-1351	382	3	,	,	PUNCT
dti-1351	382	4	murga	murga	PROPN
dti-1351	382	5	lf	lf	PROPN
dti-1351	382	6	,	,	PUNCT
dti-1351	382	7	wei	wei	PROPN
dti-1351	382	8	y	y	PROPN
dti-1351	382	9	,	,	PUNCT
dti-1351	382	10	ondrechen	ondrechen	ADV
dti-1351	382	11	mj	mj	PROPN
dti-1351	382	12	.	.	PROPN
dti-1351	382	13	prediction	prediction	NOUN
dti-1351	382	14	of	of	ADP
dti-1351	382	15	active	active	ADJ
dti-1351	382	16	sites	site	NOUN
dti-1351	382	17	for	for	ADP
dti-1351	382	18	protein	protein	NOUN
dti-1351	382	19	structures	structure	NOUN
dti-1351	382	20	from	from	ADP
dti-1351	382	21	computed	compute	VERB
dti-1351	382	22	chemical	chemical	ADJ
dti-1351	382	23	properties	property	NOUN
dti-1351	382	24	.	.	PUNCT
dti-1351	383	1	bioinformatics	bioinformatic	NOUN
dti-1351	383	2	.	.	PUNCT
dti-1351	384	1	2005;21:258–65	2005;21:258–65	PROPN
dti-1351	384	2	.	.	PUNCT
dti-1351	384	3	http://www.la-press.com	http://www.la-press.com	X