id sid tid token lemma pos dti-1355 1 1 39drug 39drug PRON dti-1355 1 2 target target NOUN dti-1355 1 3 insights insight VERB dti-1355 1 4 2014:8 2014:8 NUM dti-1355 1 5 open open ADJ dti-1355 1 6 access access NOUN dti-1355 1 7 : : PUNCT dti-1355 1 8 full full ADJ dti-1355 1 9 open open ADJ dti-1355 1 10 access access NOUN dti-1355 1 11 to to ADP dti-1355 1 12 this this PRON dti-1355 1 13 and and CCONJ dti-1355 1 14 thousands thousand NOUN dti-1355 1 15 of of ADP dti-1355 1 16 other other ADJ dti-1355 1 17 papers paper NOUN dti-1355 1 18 at at ADP dti-1355 1 19 http://www.la-press.com http://www.la-press.com X dti-1355 1 20 . . PUNCT dti-1355 2 1 drug drug NOUN dti-1355 2 2 target target NOUN dti-1355 2 3 insights insight NOUN dti-1355 2 4 febuxostat febuxostat VERB dti-1355 2 5 for for ADP dti-1355 2 6 hyperuricemia hyperuricemia NOUN dti-1355 2 7 in in ADP dti-1355 2 8 patients patient NOUN dti-1355 2 9 with with ADP dti-1355 2 10 advanced advanced ADJ dti-1355 2 11 chronic chronic ADJ dti-1355 2 12 kidney kidney NOUN dti-1355 2 13 disease disease NOUN dti-1355 2 14 tetsu tetsu PROPN dti-1355 2 15 akimoto1,2 akimoto1,2 PROPN dti-1355 2 16 , , PUNCT dti-1355 2 17 yoshiyuki yoshiyuki PROPN dti-1355 2 18 morishita1,3,4 morishita1,3,4 ADJ dti-1355 2 19 , , PUNCT dti-1355 2 20 chiharu chiharu PROPN dti-1355 2 21 ito1,3,4 ito1,3,4 PROPN dti-1355 2 22 , , PUNCT dti-1355 2 23 osamu osamu PROPN dti-1355 2 24 iimura3 iimura3 PROPN dti-1355 2 25 , , PUNCT dti-1355 2 26 sadao sadao NOUN dti-1355 2 27 tsunematsu4 tsunematsu4 NOUN dti-1355 2 28 , , PUNCT dti-1355 2 29 yuko yuko PROPN dti-1355 2 30 watanabe1 watanabe1 PROPN dti-1355 2 31 , , PUNCT dti-1355 2 32 eiji eiji PROPN dti-1355 2 33 kusano1 kusano1 PROPN dti-1355 2 34 and and CCONJ dti-1355 2 35 daisuke daisuke PROPN dti-1355 2 36 nagata1 nagata1 PROPN dti-1355 2 37 1division 1division NUM dti-1355 2 38 of of ADP dti-1355 2 39 nephrology nephrology NOUN dti-1355 2 40 , , PUNCT dti-1355 2 41 department department NOUN dti-1355 2 42 of of ADP dti-1355 2 43 internal internal ADJ dti-1355 2 44 medicine medicine NOUN dti-1355 2 45 , , PUNCT dti-1355 2 46 jichi jichi PROPN dti-1355 2 47 medical medical PROPN dti-1355 2 48 university university PROPN dti-1355 2 49 , , PUNCT dti-1355 2 50 tochigi tochigi PROPN dti-1355 2 51 , , PUNCT dti-1355 2 52 japan japan PROPN dti-1355 2 53 . . PUNCT dti-1355 3 1 2green 2green NUM dti-1355 3 2 town town NOUN dti-1355 3 3 clinic clinic NOUN dti-1355 3 4 , , PUNCT dti-1355 3 5 tochigi tochigi PROPN dti-1355 3 6 , , PUNCT dti-1355 3 7 japan japan PROPN dti-1355 3 8 . . PUNCT dti-1355 4 1 3kumakura 3kumakura NUM dti-1355 4 2 clinic clinic NOUN dti-1355 4 3 , , PUNCT dti-1355 4 4 tochigi tochigi PROPN dti-1355 4 5 , , PUNCT dti-1355 4 6 japan japan PROPN dti-1355 4 7 . . PUNCT dti-1355 5 1 4yuki 4yuki NUM dti-1355 5 2 clinic clinic NOUN dti-1355 5 3 , , PUNCT dti-1355 5 4 ibaraki ibaraki NOUN dti-1355 5 5 , , PUNCT dti-1355 5 6 japan japan PROPN dti-1355 5 7 . . PUNCT dti-1355 6 1 abstr abstr PROPN dti-1355 6 2 act act PROPN dti-1355 6 3 : : PUNCT dti-1355 6 4 febuxostat febuxostat NOUN dti-1355 6 5 is be AUX dti-1355 6 6 a a DET dti-1355 6 7 nonpurine nonpurine ADJ dti-1355 6 8 xanthine xanthine NOUN dti-1355 6 9 oxidase oxidase NOUN dti-1355 6 10 ( ( PUNCT dti-1355 6 11 xo xo NOUN dti-1355 6 12 ) ) PUNCT dti-1355 6 13 inhibitor inhibitor NOUN dti-1355 6 14 , , PUNCT dti-1355 6 15 which which PRON dti-1355 6 16 recently recently ADV dti-1355 6 17 received receive VERB dti-1355 6 18 marketing marketing NOUN dti-1355 6 19 approval approval NOUN dti-1355 6 20 . . PUNCT dti-1355 7 1 however however ADV dti-1355 7 2 , , PUNCT dti-1355 7 3 information information NOUN dti-1355 7 4 regarding regard VERB dti-1355 7 5 the the DET dti-1355 7 6 experience experience NOUN dti-1355 7 7 with with ADP dti-1355 7 8 this this DET dti-1355 7 9 agent agent NOUN dti-1355 7 10 among among ADP dti-1355 7 11 advanced advanced ADJ dti-1355 7 12 chronic chronic ADJ dti-1355 7 13 kidney kidney NOUN dti-1355 7 14 disease disease NOUN dti-1355 7 15 ( ( PUNCT dti-1355 7 16 ckd ckd NOUN dti-1355 7 17 ) ) PUNCT dti-1355 7 18 patients patient NOUN dti-1355 7 19 is be AUX dti-1355 7 20 limited limited ADJ dti-1355 7 21 . . PUNCT dti-1355 8 1 in in ADP dti-1355 8 2 the the DET dti-1355 8 3 current current ADJ dti-1355 8 4 study study NOUN dti-1355 8 5 , , PUNCT dti-1355 8 6 we we PRON dti-1355 8 7 investigated investigate VERB dti-1355 8 8 the the DET dti-1355 8 9 effects effect NOUN dti-1355 8 10 of of ADP dti-1355 8 11 oral oral ADJ dti-1355 8 12 febuxostat febuxostat NOUN dti-1355 8 13 in in ADP dti-1355 8 14 patients patient NOUN dti-1355 8 15 with with ADP dti-1355 8 16 advanced advanced ADJ dti-1355 8 17 ckd ckd PROPN dti-1355 8 18 with with ADP dti-1355 8 19 asymptomatic asymptomatic ADJ dti-1355 8 20 hyperuricemia hyperuricemia NOUN dti-1355 8 21 . . PUNCT dti-1355 9 1 we we PRON dti-1355 9 2 demonstrated demonstrate VERB dti-1355 9 3 , , PUNCT dti-1355 9 4 for for ADP dti-1355 9 5 the the DET dti-1355 9 6 first first ADJ dti-1355 9 7 time time NOUN dti-1355 9 8 , , PUNCT dti-1355 9 9 that that SCONJ dti-1355 9 10 not not PART dti-1355 9 11 only only ADV dti-1355 9 12 the the DET dti-1355 9 13 serum serum NOUN dti-1355 9 14 levels level NOUN dti-1355 9 15 of of ADP dti-1355 9 16 uric uric ADJ dti-1355 9 17 acid acid NOUN dti-1355 9 18 ( ( PUNCT dti-1355 9 19 ua ua PROPN dti-1355 9 20 ) ) PUNCT dti-1355 9 21 but but CCONJ dti-1355 9 22 also also ADV dti-1355 9 23 those those PRON dti-1355 9 24 of of ADP dti-1355 9 25 8 8 NUM dti-1355 9 26 - - PUNCT dti-1355 9 27 hydroxydeoxyguanosine hydroxydeoxyguanosine NOUN dti-1355 9 28 , , PUNCT dti-1355 9 29 an an DET dti-1355 9 30 oxidative oxidative ADJ dti-1355 9 31 stress stress NOUN dti-1355 9 32 marker marker NOUN dti-1355 9 33 , , PUNCT dti-1355 9 34 were be AUX dti-1355 9 35 significantly significantly ADV dti-1355 9 36 reduced reduce VERB dti-1355 9 37 after after ADP dti-1355 9 38 six six NUM dti-1355 9 39 months month NOUN dti-1355 9 40 of of ADP dti-1355 9 41 febuxostat febuxostat NOUN dti-1355 9 42 treatment treatment NOUN dti-1355 9 43 , , PUNCT dti-1355 9 44 with with ADP dti-1355 9 45 no no DET dti-1355 9 46 adverse adverse ADJ dti-1355 9 47 events event NOUN dti-1355 9 48 . . PUNCT dti-1355 10 1 these these DET dti-1355 10 2 results result NOUN dti-1355 10 3 encouraged encourage VERB dti-1355 10 4 us we PRON dti-1355 10 5 to to PART dti-1355 10 6 pursue pursue VERB dti-1355 10 7 further further ADJ dti-1355 10 8 investigations investigation NOUN dti-1355 10 9 regarding regard VERB dti-1355 10 10 the the DET dti-1355 10 11 clinical clinical ADJ dti-1355 10 12 impact impact NOUN dti-1355 10 13 of of ADP dti-1355 10 14 lowering lower VERB dti-1355 10 15 the the DET dti-1355 10 16 serum serum NOUN dti-1355 10 17 ua ua PROPN dti-1355 10 18 levels level NOUN dti-1355 10 19 with with ADP dti-1355 10 20 febuxostat febuxostat NOUN dti-1355 10 21 in in ADP dti-1355 10 22 advanced advanced ADJ dti-1355 10 23 ckd ckd NOUN dti-1355 10 24 patients patient NOUN dti-1355 10 25 in in ADP dti-1355 10 26 terms term NOUN dti-1355 10 27 of of ADP dti-1355 10 28 concomitantly concomitantly ADV dti-1355 10 29 reducing reduce VERB dti-1355 10 30 oxidative oxidative ADJ dti-1355 10 31 stress stress NOUN dti-1355 10 32 via via ADP dti-1355 10 33 the the DET dti-1355 10 34 blockade blockade NOUN dti-1355 10 35 of of ADP dti-1355 10 36 xo xo PROPN dti-1355 10 37 . . PUNCT dti-1355 11 1 more more ADV dti-1355 11 2 detailed detailed ADJ dti-1355 11 3 studies study NOUN dti-1355 11 4 with with ADP dti-1355 11 5 a a DET dti-1355 11 6 larger large ADJ dti-1355 11 7 number number NOUN dti-1355 11 8 of of ADP dti-1355 11 9 subjects subject NOUN dti-1355 11 10 and and CCONJ dti-1355 11 11 assessments assessment NOUN dti-1355 11 12 of of ADP dti-1355 11 13 the the DET dti-1355 11 14 effects effect NOUN dti-1355 11 15 of of ADP dti-1355 11 16 multiple multiple ADJ dti-1355 11 17 factors factor NOUN dti-1355 11 18 affecting affect VERB dti-1355 11 19 hyperuricemia hyperuricemia ADV dti-1355 11 20 , , PUNCT dti-1355 11 21 such such ADJ dti-1355 11 22 as as ADP dti-1355 11 23 age age NOUN dti-1355 11 24 , , PUNCT dti-1355 11 25 sex sex NOUN dti-1355 11 26 , , PUNCT dti-1355 11 27 and and CCONJ dti-1355 11 28 dietary dietary ADJ dti-1355 11 29 habits habit NOUN dti-1355 11 30 , , PUNCT dti-1355 11 31 would would AUX dti-1355 11 32 shed shed VERB dti-1355 11 33 light light NOUN dti-1355 11 34 on on ADP dti-1355 11 35 the the DET dti-1355 11 36 therapeutic therapeutic ADJ dti-1355 11 37 challenges challenge NOUN dti-1355 11 38 of of ADP dti-1355 11 39 treating treat VERB dti-1355 11 40 asymptomatic asymptomatic ADJ dti-1355 11 41 hyperuricemia hyperuricemia NOUN dti-1355 11 42 in in ADP dti-1355 11 43 patients patient NOUN dti-1355 11 44 with with ADP dti-1355 11 45 various various ADJ dti-1355 11 46 stages stage NOUN dti-1355 11 47 of of ADP dti-1355 11 48 ckd ckd PROPN dti-1355 11 49 . . PUNCT dti-1355 12 1 key key ADJ dti-1355 12 2 words word NOUN dti-1355 12 3 : : PUNCT dti-1355 12 4 febuxostat febuxostat NOUN dti-1355 12 5 , , PUNCT dti-1355 12 6 chronic chronic ADJ dti-1355 12 7 kidney kidney NOUN dti-1355 12 8 disease disease NOUN dti-1355 12 9 , , PUNCT dti-1355 12 10 hemodialysis hemodialysis NOUN dti-1355 12 11 , , PUNCT dti-1355 12 12 uric uric ADJ dti-1355 12 13 acid acid NOUN dti-1355 12 14 , , PUNCT dti-1355 12 15 oxidative oxidative ADJ dti-1355 12 16 stress stress NOUN dti-1355 12 17 citation citation NOUN dti-1355 12 18 : : PUNCT dti-1355 12 19 akimoto akimoto PROPN dti-1355 12 20 et et PROPN dti-1355 12 21 al al PROPN dti-1355 12 22 . . PROPN dti-1355 12 23 febuxostat febuxostat NOUN dti-1355 12 24 for for ADP dti-1355 12 25 hyperuricemia hyperuricemia NOUN dti-1355 12 26 in in ADP dti-1355 12 27 patients patient NOUN dti-1355 12 28 with with ADP dti-1355 12 29 advanced advanced ADJ dti-1355 12 30 chronic chronic ADJ dti-1355 12 31 kidney kidney NOUN dti-1355 12 32 disease disease NOUN dti-1355 12 33 . . PUNCT dti-1355 13 1 drug drug NOUN dti-1355 13 2 target target NOUN dti-1355 13 3 insights insight VERB dti-1355 13 4 2014:8 2014:8 NUM dti-1355 13 5 39–43 39–43 NUM dti-1355 13 6 doi:10.4137 doi:10.4137 NOUN dti-1355 13 7 / / SYM dti-1355 13 8 dti.s16524 dti.s16524 NOUN dti-1355 13 9 . . PUNCT dti-1355 14 1 received receive VERB dti-1355 14 2 : : PUNCT dti-1355 14 3 april april PROPN dti-1355 14 4 28 28 NUM dti-1355 14 5 , , PUNCT dti-1355 14 6 2014 2014 NUM dti-1355 14 7 . . PUNCT dti-1355 15 1 resubmitted resubmitte VERB dti-1355 15 2 : : PUNCT dti-1355 15 3 june june PROPN dti-1355 15 4 27 27 NUM dti-1355 15 5 , , PUNCT dti-1355 15 6 2014 2014 NUM dti-1355 15 7 . . PUNCT dti-1355 16 1 accepted accept VERB dti-1355 16 2 for for ADP dti-1355 16 3 publication publication NOUN dti-1355 16 4 : : PUNCT dti-1355 16 5 july july PROPN dti-1355 16 6 1 1 NUM dti-1355 16 7 , , PUNCT dti-1355 16 8 2014 2014 NUM dti-1355 16 9 . . PUNCT dti-1355 17 1 academic academic ADJ dti-1355 17 2 editor editor NOUN dti-1355 17 3 : : PUNCT dti-1355 17 4 anuj anuj PROPN dti-1355 17 5 chauhan chauhan PROPN dti-1355 17 6 , , PUNCT dti-1355 17 7 editor editor NOUN dti-1355 17 8 in in ADP dti-1355 17 9 chief chief ADJ dti-1355 17 10 type type NOUN dti-1355 17 11 : : PUNCT dti-1355 17 12 rapid rapid ADJ dti-1355 17 13 communication communication NOUN dti-1355 17 14 funding funding NOUN dti-1355 17 15 : : PUNCT dti-1355 17 16 authors author NOUN dti-1355 17 17 disclose disclose VERB dti-1355 17 18 no no DET dti-1355 17 19 funding funding NOUN dti-1355 17 20 sources source NOUN dti-1355 17 21 . . PUNCT dti-1355 18 1 competing compete VERB dti-1355 18 2 interests interest NOUN dti-1355 18 3 : : PUNCT dti-1355 18 4 authors author NOUN dti-1355 18 5 disclose disclose VERB dti-1355 18 6 no no DET dti-1355 18 7 potential potential ADJ dti-1355 18 8 conflicts conflict NOUN dti-1355 18 9 of of ADP dti-1355 18 10 interest interest NOUN dti-1355 18 11 . . PUNCT dti-1355 19 1 copyright copyright NOUN dti-1355 19 2 : : PUNCT dti-1355 19 3 © © PROPN dti-1355 19 4 the the DET dti-1355 19 5 authors author NOUN dti-1355 19 6 , , PUNCT dti-1355 19 7 publisher publisher NOUN dti-1355 19 8 and and CCONJ dti-1355 19 9 licensee licensee NOUN dti-1355 19 10 libertas liberta NOUN dti-1355 19 11 academica academica PROPN dti-1355 19 12 limited limit VERB dti-1355 19 13 . . PUNCT dti-1355 20 1 this this PRON dti-1355 20 2 is be AUX dti-1355 20 3 an an DET dti-1355 20 4 open open ADJ dti-1355 20 5 - - PUNCT dti-1355 20 6 access access NOUN dti-1355 20 7 article article NOUN dti-1355 20 8 distributed distribute VERB dti-1355 20 9 under under ADP dti-1355 20 10 the the DET dti-1355 20 11 terms term NOUN dti-1355 20 12 of of ADP dti-1355 20 13 the the DET dti-1355 20 14 creative creative ADJ dti-1355 20 15 commons common NOUN dti-1355 20 16 cc cc NOUN dti-1355 20 17 - - PUNCT dti-1355 20 18 by by ADP dti-1355 20 19 - - PUNCT dti-1355 20 20 nc nc PROPN dti-1355 20 21 3.0 3.0 NUM dti-1355 20 22 license license NOUN dti-1355 20 23 . . PUNCT dti-1355 21 1 correspondence correspondence NOUN dti-1355 21 2 : : PUNCT dti-1355 21 3 tetsu-a@jichi.ac.jp tetsu-a@jichi.ac.jp NOUN dti-1355 21 4 this this DET dti-1355 21 5 paper paper NOUN dti-1355 21 6 was be AUX dti-1355 21 7 subject subject ADJ dti-1355 21 8 to to ADP dti-1355 21 9 independent independent ADJ dti-1355 21 10 , , PUNCT dti-1355 21 11 expert expert ADJ dti-1355 21 12 peer peer NOUN dti-1355 21 13 review review NOUN dti-1355 21 14 by by ADP dti-1355 21 15 a a DET dti-1355 21 16 minimum minimum NOUN dti-1355 21 17 of of ADP dti-1355 21 18 two two NUM dti-1355 21 19 blind blind ADJ dti-1355 21 20 peer peer NOUN dti-1355 21 21 reviewers reviewer NOUN dti-1355 21 22 . . PUNCT dti-1355 22 1 all all DET dti-1355 22 2 editorial editorial ADJ dti-1355 22 3 decisions decision NOUN dti-1355 22 4 were be AUX dti-1355 22 5 made make VERB dti-1355 22 6 by by ADP dti-1355 22 7 the the DET dti-1355 22 8 independent independent ADJ dti-1355 22 9 academic academic ADJ dti-1355 22 10 editor editor NOUN dti-1355 22 11 . . PUNCT dti-1355 23 1 all all DET dti-1355 23 2 authors author NOUN dti-1355 23 3 have have AUX dti-1355 23 4 provided provide VERB dti-1355 23 5 signed sign VERB dti-1355 23 6 confirmation confirmation NOUN dti-1355 23 7 of of ADP dti-1355 23 8 their their PRON dti-1355 23 9 compliance compliance NOUN dti-1355 23 10 with with ADP dti-1355 23 11 ethical ethical ADJ dti-1355 23 12 and and CCONJ dti-1355 23 13 legal legal ADJ dti-1355 23 14 obligations obligation NOUN dti-1355 23 15 including include VERB dti-1355 23 16 ( ( PUNCT dti-1355 23 17 but but CCONJ dti-1355 23 18 not not PART dti-1355 23 19 limited limit VERB dti-1355 23 20 to to ADP dti-1355 23 21 ) ) PUNCT dti-1355 23 22 use use NOUN dti-1355 23 23 of of ADP dti-1355 23 24 any any DET dti-1355 23 25 copyrighted copyright VERB dti-1355 23 26 material material NOUN dti-1355 23 27 , , PUNCT dti-1355 23 28 compliance compliance NOUN dti-1355 23 29 with with ADP dti-1355 23 30 icmje icmje NOUN dti-1355 23 31 authorship authorship NOUN dti-1355 23 32 and and CCONJ dti-1355 23 33 competing compete VERB dti-1355 23 34 interests interest NOUN dti-1355 23 35 disclosure disclosure NOUN dti-1355 23 36 guidelines guideline NOUN dti-1355 23 37 and and CCONJ dti-1355 23 38 , , PUNCT dti-1355 23 39 where where SCONJ dti-1355 23 40 applicable applicable ADJ dti-1355 23 41 , , PUNCT dti-1355 23 42 compliance compliance NOUN dti-1355 23 43 with with ADP dti-1355 23 44 legal legal ADJ dti-1355 23 45 and and CCONJ dti-1355 23 46 ethical ethical ADJ dti-1355 23 47 guidelines guideline NOUN dti-1355 23 48 on on ADP dti-1355 23 49 human human ADJ dti-1355 23 50 and and CCONJ dti-1355 23 51 animal animal NOUN dti-1355 23 52 research research NOUN dti-1355 23 53 participants participant NOUN dti-1355 23 54 . . PUNCT dti-1355 24 1 introduction introduction NOUN dti-1355 24 2 hyperuricemia hyperuricemia ADV dti-1355 24 3 , , PUNCT dti-1355 24 4 defined define VERB dti-1355 24 5 as as ADP dti-1355 24 6 a a DET dti-1355 24 7 serum serum NOUN dti-1355 24 8 urate urate NOUN dti-1355 24 9 level level NOUN dti-1355 24 10 exceeding exceed VERB dti-1355 24 11 the the DET dti-1355 24 12 limit limit NOUN dti-1355 24 13 of of ADP dti-1355 24 14 solubility solubility NOUN dti-1355 24 15 , , PUNCT dti-1355 24 16 mirrors mirror NOUN dti-1355 24 17 supersaturation supersaturation NOUN dti-1355 24 18 of of ADP dti-1355 24 19 the the DET dti-1355 24 20 extracellular extracellular ADJ dti-1355 24 21 fluid fluid NOUN dti-1355 24 22 with with ADP dti-1355 24 23 urate urate NOUN dti-1355 24 24 , , PUNCT dti-1355 24 25 and and CCONJ dti-1355 24 26 predisposes predispose NOUN dti-1355 24 27 affected affect VERB dti-1355 24 28 subjects subject NOUN dti-1355 24 29 to to ADP dti-1355 24 30 gout gout NOUN dti-1355 24 31 , , PUNCT dti-1355 24 32 which which PRON dti-1355 24 33 is be AUX dti-1355 24 34 characterized characterize VERB dti-1355 24 35 by by ADP dti-1355 24 36 the the DET dti-1355 24 37 tissue tissue NOUN dti-1355 24 38 deposition deposition NOUN dti-1355 24 39 of of ADP dti-1355 24 40 monosodium monosodium NOUN dti-1355 24 41 urate urate NOUN dti-1355 24 42 crystals crystal NOUN dti-1355 24 43 , , PUNCT dti-1355 24 44 although although SCONJ dti-1355 24 45 it it PRON dti-1355 24 46 is be AUX dti-1355 24 47 a a DET dti-1355 24 48 necessary necessary ADJ dti-1355 24 49 but but CCONJ dti-1355 24 50 not not PART dti-1355 24 51 a a DET dti-1355 24 52 substantial substantial ADJ dti-1355 24 53 factor factor NOUN dti-1355 24 54 for for ADP dti-1355 24 55 the the DET dti-1355 24 56 development development NOUN dti-1355 24 57 of of ADP dti-1355 24 58 the the DET dti-1355 24 59 disease.1 disease.1 PROPN dti-1355 24 60     SPACE dti-1355 24 61 the the DET dti-1355 24 62 current current ADJ dti-1355 24 63 uratelowering uratelowere VERB dti-1355 24 64 strategies strategy NOUN dti-1355 24 65 include include VERB dti-1355 24 66 reducing reduce VERB dti-1355 24 67 the the DET dti-1355 24 68 urate urate NOUN dti-1355 24 69 production production NOUN dti-1355 24 70 with with ADP dti-1355 24 71 xanthine xanthine NOUN dti-1355 24 72 oxidase oxidase PROPN dti-1355 24 73 ( ( PUNCT dti-1355 24 74 xo xo NOUN dti-1355 24 75 ) ) PUNCT dti-1355 24 76 inhibitors inhibitor NOUN dti-1355 24 77 and and CCONJ dti-1355 24 78 accelerating accelerate VERB dti-1355 24 79 the the DET dti-1355 24 80 urinary urinary ADJ dti-1355 24 81 excretion excretion NOUN dti-1355 24 82 of of ADP dti-1355 24 83 uric uric ADJ dti-1355 24 84 acid acid NOUN dti-1355 24 85 ( ( PUNCT dti-1355 24 86 ua ua PROPN dti-1355 24 87 ) ) PUNCT dti-1355 24 88 with with ADP dti-1355 24 89 uricosuric uricosuric ADJ dti-1355 24 90 agents.2,3 agents.2,3 ADJ dti-1355 24 91 uricosuric uricosuric ADJ dti-1355 24 92 agents agent NOUN dti-1355 24 93 , , PUNCT dti-1355 24 94 such such ADJ dti-1355 24 95 as as ADP dti-1355 24 96 probenecid probenecid PROPN dti-1355 24 97 and and CCONJ dti-1355 24 98 benzbromarone benzbromarone NOUN dti-1355 24 99 , , PUNCT dti-1355 24 100 may may AUX dti-1355 24 101 have have VERB dti-1355 24 102 limited limit VERB dti-1355 24 103 effectiveness effectiveness NOUN dti-1355 24 104 in in ADP dti-1355 24 105 patients patient NOUN dti-1355 24 106 with with ADP dti-1355 24 107 reduced reduced ADJ dti-1355 24 108 renal renal ADJ dti-1355 24 109 function.3,4 function.3,4 ADJ dti-1355 24 110     SPACE dti-1355 24 111 the the DET dti-1355 24 112 purine purine NOUN dti-1355 24 113 analog analog NOUN dti-1355 24 114 xo xo PROPN dti-1355 24 115 inhibitor inhibitor PROPN dti-1355 24 116 , , PUNCT dti-1355 24 117 allopurinol allopurinol NOUN dti-1355 24 118 , , PUNCT dti-1355 24 119 has have AUX dti-1355 24 120 remained remained AUX dti-1355 24 121 widely widely ADV dti-1355 24 122 prescribed prescribe VERB dti-1355 24 123 for for ADP dti-1355 24 124 the the DET dti-1355 24 125 treatment treatment NOUN dti-1355 24 126 of of ADP dti-1355 24 127 hyperuricemia hyperuricemia NOUN dti-1355 24 128 , , PUNCT dti-1355 24 129 but but CCONJ dti-1355 24 130 requires require VERB dti-1355 24 131 dose dose NOUN dti-1355 24 132 adjustment adjustment NOUN dti-1355 24 133 in in ADP dti-1355 24 134 subjects subject NOUN dti-1355 24 135 with with ADP dti-1355 24 136 renal renal ADJ dti-1355 24 137 impairment impairment NOUN dti-1355 24 138 , , PUNCT dti-1355 24 139 which which PRON dti-1355 24 140 may may AUX dti-1355 24 141 lead lead VERB dti-1355 24 142 to to ADP dti-1355 24 143 a a DET dti-1355 24 144 reduced reduce VERB dti-1355 24 145 benefit.2,3,5,6 benefit.2,3,5,6 ADJ dti-1355 24 146 febuxostat febuxostat NOUN dti-1355 24 147 , , PUNCT dti-1355 24 148 a a DET dti-1355 24 149 nonpurine nonpurine ADJ dti-1355 24 150 xo xo PROPN dti-1355 24 151 inhibitor inhibitor NOUN dti-1355 24 152 that that PRON dti-1355 24 153 recently recently ADV dti-1355 24 154 received receive VERB dti-1355 24 155 marketing marketing NOUN dti-1355 24 156 approval approval NOUN dti-1355 24 157 , , PUNCT dti-1355 24 158 has have AUX dti-1355 24 159 been be AUX dti-1355 24 160 focused focus VERB dti-1355 24 161 on on ADP dti-1355 24 162 as as ADP dti-1355 24 163 an an DET dti-1355 24 164 alternative alternative ADJ dti-1355 24 165 option option NOUN dti-1355 24 166 for for ADP dti-1355 24 167 the the DET dti-1355 24 168 treatment treatment NOUN dti-1355 24 169 of of ADP dti-1355 24 170 hyperuricemia hyperuricemia NOUN dti-1355 24 171 in in ADP dti-1355 24 172 patients patient NOUN dti-1355 24 173 with with ADP dti-1355 24 174 chronic chronic ADJ dti-1355 24 175 kidney kidney NOUN dti-1355 24 176 disease disease NOUN dti-1355 24 177 ( ( PUNCT dti-1355 24 178 ckd ckd PROPN dti-1355 24 179 ) ) PUNCT dti-1355 24 180 because because SCONJ dti-1355 24 181 it it PRON dti-1355 24 182 undergoes undergo VERB dti-1355 24 183 hepatic hepatic ADJ dti-1355 24 184 metabolism metabolism NOUN dti-1355 24 185 and and CCONJ dti-1355 24 186 may may AUX dti-1355 24 187 require require VERB dti-1355 24 188 less less ADJ dti-1355 24 189 dose dose NOUN dti-1355 24 190 adjustment adjustment NOUN dti-1355 24 191 in in ADP dti-1355 24 192 association association NOUN dti-1355 24 193 with with ADP dti-1355 24 194 the the DET dti-1355 24 195 renal renal ADJ dti-1355 24 196 function.6,7 function.6,7 PROPN dti-1355 24 197     SPACE dti-1355 24 198 moreover moreover ADV dti-1355 24 199 , , PUNCT dti-1355 24 200 several several ADJ dti-1355 24 201 lines line NOUN dti-1355 24 202 of of ADP dti-1355 24 203 evidence evidence NOUN dti-1355 24 204 have have AUX dti-1355 24 205 focused focus VERB dti-1355 24 206 on on ADP dti-1355 24 207 the the DET dti-1355 24 208 blockade blockade NOUN dti-1355 24 209 of of ADP dti-1355 24 210 xo xo PROPN dti-1355 24 211 activity activity NOUN dti-1355 24 212 as as ADP dti-1355 24 213 a a DET dti-1355 24 214 potential potential ADJ dti-1355 24 215 therapeutic therapeutic ADJ dti-1355 24 216 strategy strategy NOUN dti-1355 24 217 for for ADP dti-1355 24 218 various various ADJ dti-1355 24 219 other other ADJ dti-1355 24 220 kinds kind NOUN dti-1355 24 221 of of ADP dti-1355 24 222 oxidative oxidative ADJ dti-1355 24 223 stress stress NOUN dti-1355 24 224 - - PUNCT dti-1355 24 225 mediated mediate VERB dti-1355 24 226 tissue tissue NOUN dti-1355 24 227 and and CCONJ dti-1355 24 228 vascular vascular ADJ dti-1355 24 229 injuries.8,9 injuries.8,9 NOUN dti-1355 24 230     SPACE dti-1355 24 231 however however ADV dti-1355 24 232 , , PUNCT dti-1355 24 233 information information NOUN dti-1355 24 234 regarding regard VERB dti-1355 24 235 the the DET dti-1355 24 236 experience experience NOUN dti-1355 24 237 with with ADP dti-1355 24 238 this this DET dti-1355 24 239 therapeutic therapeutic ADJ dti-1355 24 240 agent agent NOUN dti-1355 24 241 among among ADP dti-1355 24 242 patients patient NOUN dti-1355 24 243 with with ADP dti-1355 24 244 advanced advanced ADJ dti-1355 24 245 ckd ckd PROPN dti-1355 24 246 is be AUX dti-1355 24 247 limited.7 limited.7 NOUN dti-1355 24 248     SPACE dti-1355 24 249 in in ADP dti-1355 24 250 this this DET dti-1355 24 251 regard regard NOUN dti-1355 24 252 , , PUNCT dti-1355 24 253 the the DET dti-1355 24 254 current current ADJ dti-1355 24 255 study study NOUN dti-1355 24 256 investigated investigate VERB dti-1355 24 257 the the DET dti-1355 24 258 effects effect NOUN dti-1355 24 259 of of ADP dti-1355 24 260 febuxostat febuxostat NOUN dti-1355 24 261 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1355 24 262 http://www.la-press.com http://www.la-press.com X dti-1355 24 263 http://www.la-press.com http://www.la-press.com X dti-1355 25 1 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1355 25 2 http://dx.doi.org/10.4137/dti.s16524 http://dx.doi.org/10.4137/dti.s16524 PROPN dti-1355 25 3 http://creativecommons.org/licenses/by-nc/3.0/ http://creativecommons.org/licenses/by-nc/3.0/ NOUN dti-1355 26 1 http://creativecommons.org/licenses/by-nc/3.0/ http://creativecommons.org/licenses/by-nc/3.0/ NOUN dti-1355 26 2 mailto:tetsu-a@jichi.ac.jp mailto:tetsu-a@jichi.ac.jp ADV dti-1355 26 3 akimoto akimoto PROPN dti-1355 26 4 et et PROPN dti-1355 26 5 al al PROPN dti-1355 26 6 40 40 NUM dti-1355 26 7 drug drug NOUN dti-1355 26 8 target target NOUN dti-1355 26 9 insights insight NOUN dti-1355 26 10 2014:8 2014:8 NUM dti-1355 26 11 in in ADP dti-1355 26 12 patients patient NOUN dti-1355 26 13 with with ADP dti-1355 26 14 advanced advanced ADJ dti-1355 26 15 ckd ckd PROPN dti-1355 26 16 with with ADP dti-1355 26 17 hyperuricemia hyperuricemia NOUN dti-1355 26 18 in in ADP dti-1355 26 19 terms term NOUN dti-1355 26 20 of of ADP dti-1355 26 21 the the DET dti-1355 26 22 reduction reduction NOUN dti-1355 26 23 of of ADP dti-1355 26 24 the the DET dti-1355 26 25 serum serum PROPN dti-1355 26 26 ua ua PROPN dti-1355 26 27 levels level NOUN dti-1355 26 28 and and CCONJ dti-1355 26 29 the the DET dti-1355 26 30 longitudinal longitudinal ADJ dti-1355 26 31 changes change NOUN dti-1355 26 32 in in ADP dti-1355 26 33 several several ADJ dti-1355 26 34 serum serum NOUN dti-1355 26 35 indicators indicator NOUN dti-1355 26 36 for for ADP dti-1355 26 37 oxidative oxidative ADJ dti-1355 26 38 stress stress NOUN dti-1355 26 39 . . PUNCT dti-1355 27 1 materials material NOUN dti-1355 27 2 and and CCONJ dti-1355 27 3 methods method NOUN dti-1355 27 4 seventeen seventeen NUM dti-1355 27 5 patients patient NOUN dti-1355 27 6 on on ADP dti-1355 27 7 chronic chronic ADJ dti-1355 27 8 hemodialysis hemodialysis NOUN dti-1355 27 9 ( ( PUNCT dti-1355 27 10 hd hd NOUN dti-1355 27 11 ) ) PUNCT dti-1355 27 12 treatment treatment NOUN dti-1355 27 13 who who PRON dti-1355 27 14 had have VERB dti-1355 27 15 serum serum PROPN dti-1355 27 16 ua ua PROPN dti-1355 27 17 levels level NOUN dti-1355 27 18 above above ADP dti-1355 27 19 8.0 8.0 NUM dti-1355 27 20     SPACE dti-1355 27 21 mg mg PROPN dti-1355 27 22 / / SYM dti-1355 27 23 dl dl PROPN dti-1355 27 24 and and CCONJ dti-1355 27 25 who who PRON dti-1355 27 26 were be AUX dti-1355 27 27 not not PART dti-1355 27 28 receiving receive VERB dti-1355 27 29 anti anti ADJ dti-1355 27 30 - - ADJ dti-1355 27 31 hyperuricemic hyperuricemic ADJ dti-1355 27 32 agents agent NOUN dti-1355 27 33 participated participate VERB dti-1355 27 34 in in ADP dti-1355 27 35 the the DET dti-1355 27 36 study study NOUN dti-1355 27 37 . . PUNCT dti-1355 28 1 all all DET dti-1355 28 2 subjects subject NOUN dti-1355 28 3 had have VERB dti-1355 28 4 oliguria oliguria NOUN dti-1355 28 5 or or CCONJ dti-1355 28 6 anuria anuria NOUN dti-1355 28 7 . . PUNCT dti-1355 29 1 the the DET dti-1355 29 2 subjects subject NOUN dti-1355 29 3 had have VERB dti-1355 29 4 to to PART dti-1355 29 5 be be AUX dti-1355 29 6 in in ADP dti-1355 29 7 stable stable ADJ dti-1355 29 8 condition condition NOUN dti-1355 29 9 , , PUNCT dti-1355 29 10 and and CCONJ dti-1355 29 11 they they PRON dti-1355 29 12 had have VERB dti-1355 29 13 no no DET dti-1355 29 14 history history NOUN dti-1355 29 15 of of ADP dti-1355 29 16 active active ADJ dti-1355 29 17 liver liver NOUN dti-1355 29 18 diseases disease NOUN dti-1355 29 19 or or CCONJ dti-1355 29 20 any any DET dti-1355 29 21 other other ADJ dti-1355 29 22 significant significant ADJ dti-1355 29 23 medical medical ADJ dti-1355 29 24 status status NOUN dti-1355 29 25 , , PUNCT dti-1355 29 26 no no DET dti-1355 29 27 change change NOUN dti-1355 29 28 in in ADP dti-1355 29 29 diuretics diuretic NOUN dti-1355 29 30 or or CCONJ dti-1355 29 31 steroid steroid NOUN dti-1355 29 32 therapy therapy NOUN dti-1355 29 33 within within ADP dti-1355 29 34 one one NUM dti-1355 29 35 month month NOUN dti-1355 29 36 of of ADP dti-1355 29 37 study study NOUN dti-1355 29 38 enrollment enrollment NOUN dti-1355 29 39 and and CCONJ dti-1355 29 40 were be AUX dti-1355 29 41 not not PART dti-1355 29 42 chronic chronic ADJ dti-1355 29 43 users user NOUN dti-1355 29 44 of of ADP dti-1355 29 45 any any DET dti-1355 29 46 nonsteroidal nonsteroidal NOUN dti-1355 29 47 anti anti ADJ dti-1355 29 48 - - ADJ dti-1355 29 49 inflammatory inflammatory ADJ dti-1355 29 50 drugs drug NOUN dti-1355 29 51 . . PUNCT dti-1355 30 1 the the DET dti-1355 30 2 usual usual ADJ dti-1355 30 3 medications medication NOUN dti-1355 30 4 , , PUNCT dti-1355 30 5 such such ADJ dti-1355 30 6 as as ADP dti-1355 30 7 anti anti ADJ dti-1355 30 8 - - ADJ dti-1355 30 9 hypertensive hypertensive ADJ dti-1355 30 10 agents agent NOUN dti-1355 30 11 , , PUNCT dti-1355 30 12 erythropoietin erythropoietin NOUN dti-1355 30 13 , , PUNCT dti-1355 30 14 and and CCONJ dti-1355 30 15 phosphate phosphate ADJ dti-1355 30 16 binders binder NOUN dti-1355 30 17 , , PUNCT dti-1355 30 18 were be AUX dti-1355 30 19 continued continue VERB dti-1355 30 20 during during ADP dti-1355 30 21 the the DET dti-1355 30 22 study study NOUN dti-1355 30 23 period period NOUN dti-1355 30 24 . . PUNCT dti-1355 31 1 sex sex NOUN dti-1355 31 2 was be AUX dti-1355 31 3 not not PART dti-1355 31 4 considered consider VERB dti-1355 31 5 . . PUNCT dti-1355 32 1 the the DET dti-1355 32 2 exclusion exclusion NOUN dti-1355 32 3 criteria criterion NOUN dti-1355 32 4 were be AUX dti-1355 32 5 as as SCONJ dti-1355 32 6 follows follow VERB dti-1355 32 7 : : PUNCT dti-1355 32 8 age age NOUN dti-1355 32 9 20 20 PROPN dti-1355 32 10     SPACE dti-1355 32 11 years year NOUN dti-1355 32 12 or or CCONJ dti-1355 32 13 90 90 NOUN dti-1355 32 14     SPACE dti-1355 32 15 years year NOUN dti-1355 32 16 , , PUNCT dti-1355 32 17 type type NOUN dti-1355 32 18 i i PRON dti-1355 32 19 diabetes diabete VERB dti-1355 32 20 mellitus mellitus NOUN dti-1355 32 21 or or CCONJ dti-1355 32 22 type type NOUN dti-1355 32 23 ii ii NOUN dti-1355 32 24 diabetes diabetes NOUN dti-1355 32 25 mellitus mellitus NOUN dti-1355 32 26 with with ADP dti-1355 32 27 poor poor ADJ dti-1355 32 28 glucose glucose NOUN dti-1355 32 29 control control NOUN dti-1355 32 30 ( ( PUNCT dti-1355 32 31 glycosylated glycosylated ADJ dti-1355 32 32 hemoglobin hemoglobin NOUN dti-1355 32 33 9 9 NOUN dti-1355 32 34 % % NOUN dti-1355 32 35 at at ADP dti-1355 32 36 the the DET dti-1355 32 37 start start NOUN dti-1355 32 38 of of ADP dti-1355 32 39 the the DET dti-1355 32 40 observation observation NOUN dti-1355 32 41 period period NOUN dti-1355 32 42 ) ) PUNCT dti-1355 32 43 , , PUNCT dti-1355 32 44 treatment treatment NOUN dti-1355 32 45 with with ADP dti-1355 32 46 mercaptopurine mercaptopurine ADJ dti-1355 32 47 hydrate hydrate NOUN dti-1355 32 48 or or CCONJ dti-1355 32 49 azathiopurine azathiopurine NOUN dti-1355 32 50 , , PUNCT dti-1355 32 51 pregnancy pregnancy NOUN dti-1355 32 52 , , PUNCT dti-1355 32 53 and and CCONJ dti-1355 32 54 any any DET dti-1355 32 55 medical medical ADJ dti-1355 32 56 or or CCONJ dti-1355 32 57 surgical surgical ADJ dti-1355 32 58 conditions condition NOUN dti-1355 32 59 that that PRON dti-1355 32 60 made make VERB dti-1355 32 61 patients patient NOUN dti-1355 32 62 unsuitable unsuitable ADJ dti-1355 32 63 for for ADP dti-1355 32 64 this this DET dti-1355 32 65 study study NOUN dti-1355 32 66 as as SCONJ dti-1355 32 67 judged judge VERB dti-1355 32 68 by by ADP dti-1355 32 69 the the DET dti-1355 32 70 attending attend VERB dti-1355 32 71 physician physician NOUN dti-1355 32 72 . . PUNCT dti-1355 33 1 all all DET dti-1355 33 2 patients patient NOUN dti-1355 33 3 were be AUX dti-1355 33 4 assigned assign VERB dti-1355 33 5 to to ADP dti-1355 33 6 oral oral ADJ dti-1355 33 7 febuxostat febuxostat NOUN dti-1355 33 8 and and CCONJ dti-1355 33 9 entered enter VERB dti-1355 33 10 the the DET dti-1355 33 11 six six NUM dti-1355 33 12 - - PUNCT dti-1355 33 13 month month NOUN dti-1355 33 14 treatment treatment NOUN dti-1355 33 15 period period NOUN dti-1355 33 16 from from ADP dti-1355 33 17 july july PROPN dti-1355 33 18 through through ADP dti-1355 33 19 august august PROPN dti-1355 33 20 2012 2012 NUM dti-1355 33 21 , , PUNCT dti-1355 33 22 during during ADP dti-1355 33 23 which which PRON dti-1355 33 24 they they PRON dti-1355 33 25 initially initially ADV dti-1355 33 26 received receive VERB dti-1355 33 27 febuxostat febuxostat NOUN dti-1355 33 28 10 10 NUM dti-1355 33 29     SPACE dti-1355 33 30 mg mg PROPN dti-1355 33 31 orally orally ADV dti-1355 33 32 once once ADV dti-1355 33 33 daily daily ADV dti-1355 33 34 in in ADP dti-1355 33 35 the the DET dti-1355 33 36 morning morning NOUN dti-1355 33 37 . . PUNCT dti-1355 34 1 the the DET dti-1355 34 2 target target NOUN dti-1355 34 3 serum serum NOUN dti-1355 34 4 ua ua PROPN dti-1355 34 5 level level NOUN dti-1355 34 6 was be AUX dti-1355 34 7 6.0 6.0 NOUN dti-1355 34 8     SPACE dti-1355 34 9 mg mg PROPN dti-1355 34 10 / / SYM dti-1355 34 11 dl dl PROPN dti-1355 34 12 , , PUNCT dti-1355 34 13 and and CCONJ dti-1355 34 14 the the DET dti-1355 34 15 dose dose NOUN dti-1355 34 16 of of ADP dti-1355 34 17 febuxostat febuxostat NOUN dti-1355 34 18 was be AUX dti-1355 34 19 titrated titrate VERB dti-1355 34 20 or or CCONJ dti-1355 34 21 increased increase VERB dti-1355 34 22 up up ADP dti-1355 34 23 to to ADP dti-1355 34 24 a a DET dti-1355 34 25 maximum maximum NOUN dti-1355 34 26 of of ADP dti-1355 34 27 40 40 NUM dti-1355 34 28     SPACE dti-1355 34 29 mg mg PROPN dti-1355 34 30 / / SYM dti-1355 34 31 day day NOUN dti-1355 34 32 . . PUNCT dti-1355 35 1 the the DET dti-1355 35 2 blood blood NOUN dti-1355 35 3 pressure pressure NOUN dti-1355 35 4 ( ( PUNCT dti-1355 35 5 bp bp PROPN dti-1355 35 6 ) ) PUNCT dti-1355 35 7 was be AUX dti-1355 35 8 measured measure VERB dti-1355 35 9 before before ADP dti-1355 35 10 all all DET dti-1355 35 11 hd hd NOUN dti-1355 35 12 sessions session NOUN dti-1355 35 13 , , PUNCT dti-1355 35 14 and and CCONJ dti-1355 35 15 the the DET dti-1355 35 16 data datum NOUN dti-1355 35 17 regarding regard VERB dti-1355 35 18 the the DET dti-1355 35 19 systolic systolic ADJ dti-1355 35 20 bp bp PROPN dti-1355 35 21 and and CCONJ dti-1355 35 22 diastolic diastolic PROPN dti-1355 35 23 bp bp PROPN dti-1355 35 24 were be AUX dti-1355 35 25 the the DET dti-1355 35 26 average average NOUN dti-1355 35 27 of of ADP dti-1355 35 28 each each DET dti-1355 35 29 value value NOUN dti-1355 35 30 on on ADP dti-1355 35 31 the the DET dti-1355 35 32 last last ADJ dti-1355 35 33 hd hd NOUN dti-1355 35 34 day day NOUN dti-1355 35 35 of of ADP dti-1355 35 36 the the DET dti-1355 35 37 week week NOUN dti-1355 35 38 . . PUNCT dti-1355 36 1 the the DET dti-1355 36 2 blood blood NOUN dti-1355 36 3 samples sample NOUN dti-1355 36 4 were be AUX dti-1355 36 5 obtained obtain VERB dti-1355 36 6 from from ADP dti-1355 36 7 vascular vascular ADJ dti-1355 36 8 access access NOUN dti-1355 36 9 , , PUNCT dti-1355 36 10 including include VERB dti-1355 36 11 arteriovenous arteriovenous ADJ dti-1355 36 12 fistulas fistula NOUN dti-1355 36 13 and and CCONJ dti-1355 36 14 arteriovenous arteriovenous ADJ dti-1355 36 15 grafts graft NOUN dti-1355 36 16 , , PUNCT dti-1355 36 17 before before ADP dti-1355 36 18 hd hd NOUN dti-1355 36 19 sessions session NOUN dti-1355 36 20 . . PUNCT dti-1355 37 1 the the DET dti-1355 37 2 hemoglobin hemoglobin NOUN dti-1355 37 3 ( ( PUNCT dti-1355 37 4 hb hb PROPN dti-1355 37 5 ) ) PUNCT dti-1355 37 6 , , PUNCT dti-1355 37 7 hematocrit hematocrit PROPN dti-1355 37 8 ( ( PUNCT dti-1355 37 9 hct hct PROPN dti-1355 37 10 ) ) PUNCT dti-1355 37 11 , , PUNCT dti-1355 37 12 platelet platelet NOUN dti-1355 37 13 count count NOUN dti-1355 37 14 ( ( PUNCT dti-1355 37 15 plt plt NOUN dti-1355 37 16 ) ) PUNCT dti-1355 37 17 , , PUNCT dti-1355 37 18 serum serum NOUN dti-1355 37 19 levels level NOUN dti-1355 37 20 of of ADP dti-1355 37 21 ua ua PROPN dti-1355 37 22 , , PUNCT dti-1355 37 23 blood blood NOUN dti-1355 37 24 urea urea NOUN dti-1355 37 25 nitrogen nitrogen PROPN dti-1355 37 26 ( ( PUNCT dti-1355 37 27 bun bun PROPN dti-1355 37 28 ) ) PUNCT dti-1355 37 29 , , PUNCT dti-1355 37 30 creatinine creatinine NOUN dti-1355 37 31 ( ( PUNCT dti-1355 37 32 cr cr NOUN dti-1355 37 33 ) ) PUNCT dti-1355 37 34 , , PUNCT dti-1355 37 35 sodium sodium NOUN dti-1355 37 36 ( ( PUNCT dti-1355 37 37 na na NOUN dti-1355 37 38 ) ) PUNCT dti-1355 37 39 , , PUNCT dti-1355 37 40 chloride chloride NOUN dti-1355 37 41 ( ( PUNCT dti-1355 37 42 cl cl NOUN dti-1355 37 43 ) ) PUNCT dti-1355 37 44 , , PUNCT dti-1355 37 45 potassium potassium NOUN dti-1355 37 46 ( ( PUNCT dti-1355 37 47 k k NOUN dti-1355 37 48 ) ) PUNCT dti-1355 37 49 , , PUNCT dti-1355 37 50 calcium calcium NOUN dti-1355 37 51 ( ( PUNCT dti-1355 37 52 ca ca NOUN dti-1355 37 53 ) ) PUNCT dti-1355 37 54 , , PUNCT dti-1355 37 55 inorganic inorganic ADJ dti-1355 37 56 phosphate phosphate NOUN dti-1355 37 57 ( ( PUNCT dti-1355 37 58 pi pi NOUN dti-1355 37 59 ) ) PUNCT dti-1355 37 60 , , PUNCT dti-1355 37 61 aspartate aspartate NOUN dti-1355 37 62 aminotransferase aminotransferase NOUN dti-1355 37 63 ( ( PUNCT dti-1355 37 64 ast ast PROPN dti-1355 37 65 ) ) PUNCT dti-1355 37 66 , , PUNCT dti-1355 37 67 alanine alanine NOUN dti-1355 37 68 aminotransferase aminotransferase PROPN dti-1355 37 69 ( ( PUNCT dti-1355 37 70 alt alt ADJ dti-1355 37 71 ) ) PUNCT dti-1355 37 72 , , PUNCT dti-1355 37 73 and and CCONJ dti-1355 37 74 lactate lactate NOUN dti-1355 37 75 dehydrogenase dehydrogenase NOUN dti-1355 37 76 ( ( PUNCT dti-1355 37 77 ldh ldh NOUN dti-1355 37 78 ) ) PUNCT dti-1355 37 79 were be AUX dti-1355 37 80 measured measure VERB dti-1355 37 81 at at ADP dti-1355 37 82 baseline baseline PROPN dti-1355 37 83 ( ( PUNCT dti-1355 37 84 week week NOUN dti-1355 37 85 0 0 NUM dti-1355 37 86 ) ) PUNCT dti-1355 37 87 and and CCONJ dti-1355 37 88 every every DET dti-1355 37 89 four four NUM dti-1355 37 90 weeks week NOUN dti-1355 37 91 during during ADP dti-1355 37 92 the the DET dti-1355 37 93 observation observation NOUN dti-1355 37 94 period period NOUN dti-1355 37 95 . . PUNCT dti-1355 38 1 the the DET dti-1355 38 2 serum serum NOUN dti-1355 38 3 levels level NOUN dti-1355 38 4 of of ADP dti-1355 38 5 8 8 NUM dti-1355 38 6 - - PUNCT dti-1355 38 7 hydroxydeoxyguanosine hydroxydeoxyguanosine NOUN dti-1355 38 8 ( ( PUNCT dti-1355 38 9 8 8 NUM dti-1355 38 10 - - NUM dti-1355 38 11 ohdg ohdg NUM dti-1355 38 12 ) ) PUNCT dti-1355 38 13 , , PUNCT dti-1355 38 14 3 3 NUM dti-1355 38 15 - - PUNCT dti-1355 38 16 nitrotyrosine nitrotyrosine NOUN dti-1355 38 17 - - PUNCT dti-1355 38 18 modified modify VERB dti-1355 38 19 proteins protein NOUN dti-1355 38 20 ( ( PUNCT dti-1355 38 21 3 3 NUM dti-1355 38 22 - - PUNCT dti-1355 38 23 nt nt NOUN dti-1355 38 24 ) ) PUNCT dti-1355 38 25 , , PUNCT dti-1355 38 26 and and CCONJ dti-1355 38 27 protein protein NOUN dti-1355 38 28 carbonyls carbonyls NOUN dti-1355 38 29 were be AUX dti-1355 38 30 determined determine VERB dti-1355 38 31 at at ADP dti-1355 38 32 baseline baseline NOUN dti-1355 38 33 and and CCONJ dti-1355 38 34 at at ADP dti-1355 38 35 weeks week NOUN dti-1355 38 36 4 4 NUM dti-1355 38 37 , , PUNCT dti-1355 38 38 12 12 NUM dti-1355 38 39 , , PUNCT dti-1355 38 40 and and CCONJ dti-1355 38 41 24 24 NUM dti-1355 38 42     SPACE dti-1355 38 43 during during ADP dti-1355 38 44 the the DET dti-1355 38 45 treatment treatment NOUN dti-1355 38 46 period period NOUN dti-1355 38 47 . . PUNCT dti-1355 39 1 the the DET dti-1355 39 2 serum serum NOUN dti-1355 39 3 levels level NOUN dti-1355 39 4 of of ADP dti-1355 39 5 8 8 NUM dti-1355 39 6 - - PUNCT dti-1355 39 7 ohdg ohdg NOUN dti-1355 39 8 were be AUX dti-1355 39 9 measured measure VERB dti-1355 39 10 by by ADP dti-1355 39 11 an an DET dti-1355 39 12 enzyme enzyme NOUN dti-1355 39 13 - - PUNCT dti-1355 39 14 linked link VERB dti-1355 39 15 immunosorbent immunosorbent NOUN dti-1355 39 16 assay assay PROPN dti-1355 39 17 ( ( PUNCT dti-1355 39 18 elisa elisa NOUN dti-1355 39 19 ) ) PUNCT dti-1355 39 20 as as SCONJ dti-1355 39 21 described describe VERB dti-1355 39 22 previously.10 previously.10 PROPN dti-1355 39 23     SPACE dti-1355 39 24 the the DET dti-1355 39 25 elisa elisa NOUN dti-1355 39 26 method method NOUN dti-1355 39 27 was be AUX dti-1355 39 28 also also ADV dti-1355 39 29 used use VERB dti-1355 39 30 to to PART dti-1355 39 31 measure measure VERB dti-1355 39 32 the the DET dti-1355 39 33 serum serum NOUN dti-1355 39 34 levels level NOUN dti-1355 39 35 of of ADP dti-1355 39 36 3 3 NUM dti-1355 39 37 - - PUNCT dti-1355 39 38 nt not PART dti-1355 39 39 ( ( PUNCT dti-1355 39 40 japan japan PROPN dti-1355 39 41 institute institute PROPN dti-1355 39 42 for for ADP dti-1355 39 43 the the DET dti-1355 39 44 control control NOUN dti-1355 39 45 of of ADP dti-1355 39 46 aging aging NOUN dti-1355 39 47 , , PUNCT dti-1355 39 48 nikken nikken PROPN dti-1355 39 49 seil seil NOUN dti-1355 39 50 co co PROPN dti-1355 39 51 , , PUNCT dti-1355 39 52 shizuoka shizuoka PROPN dti-1355 39 53 , , PUNCT dti-1355 39 54 japan japan PROPN dti-1355 39 55 ) ) PUNCT dti-1355 39 56 and and CCONJ dti-1355 39 57 protein protein NOUN dti-1355 39 58 carbonyls carbonyls NOUN dti-1355 39 59 ( ( PUNCT dti-1355 39 60 biocell biocell PROPN dti-1355 39 61 co co NOUN dti-1355 39 62 , , PUNCT dti-1355 39 63 auckland auckland PROPN dti-1355 39 64 , , PUNCT dti-1355 39 65 new new PROPN dti-1355 39 66 zealand zealand PROPN dti-1355 39 67 ) ) PUNCT dti-1355 39 68 . . PUNCT dti-1355 40 1 this this DET dti-1355 40 2 study study NOUN dti-1355 40 3 was be AUX dti-1355 40 4 performed perform VERB dti-1355 40 5 in in ADP dti-1355 40 6 accordance accordance NOUN dti-1355 40 7 with with ADP dti-1355 40 8 the the DET dti-1355 40 9 declaration declaration NOUN dti-1355 40 10 of of ADP dti-1355 40 11 helsinki helsinki PROPN dti-1355 40 12 and and CCONJ dti-1355 40 13 was be AUX dti-1355 40 14 approved approve VERB dti-1355 40 15 by by ADP dti-1355 40 16 the the DET dti-1355 40 17 medical medical ADJ dti-1355 40 18 ethics ethics PROPN dti-1355 40 19 committee committee PROPN dti-1355 40 20 of of ADP dti-1355 40 21 jichi jichi PROPN dti-1355 40 22 medical medical PROPN dti-1355 40 23 university university NOUN dti-1355 40 24 , , PUNCT dti-1355 40 25 and and CCONJ dti-1355 40 26 all all DET dti-1355 40 27 patients patient NOUN dti-1355 40 28 included include VERB dti-1355 40 29 in in ADP dti-1355 40 30 the the DET dti-1355 40 31 present present ADJ dti-1355 40 32 study study NOUN dti-1355 40 33 provided provide VERB dti-1355 40 34 their their PRON dti-1355 40 35 informed informed ADJ dti-1355 40 36 consent consent NOUN dti-1355 40 37 . . PUNCT dti-1355 41 1 the the DET dti-1355 41 2 data datum NOUN dti-1355 41 3 were be AUX dti-1355 41 4 expressed express VERB dti-1355 41 5 either either CCONJ dti-1355 41 6 as as ADP dti-1355 41 7 the the DET dti-1355 41 8 number number NOUN dti-1355 41 9 of of ADP dti-1355 41 10 participants participant NOUN dti-1355 41 11 or or CCONJ dti-1355 41 12 as as ADP dti-1355 41 13 the the DET dti-1355 41 14 percentage percentage NOUN dti-1355 41 15 ( ( PUNCT dti-1355 41 16 % % NOUN dti-1355 41 17 ) ) PUNCT dti-1355 41 18 of of ADP dti-1355 41 19 the the DET dti-1355 41 20 study study NOUN dti-1355 41 21 population population NOUN dti-1355 41 22 . . PUNCT dti-1355 42 1 the the DET dti-1355 42 2 remaining remain VERB dti-1355 42 3 data datum NOUN dti-1355 42 4 were be AUX dti-1355 42 5 expressed express VERB dti-1355 42 6 as as ADP dti-1355 42 7 the the DET dti-1355 42 8 means means PROPN dti-1355 42 9 ± ± NUM dti-1355 42 10 standard standard ADJ dti-1355 42 11 deviation deviation NOUN dti-1355 42 12 ( ( PUNCT dti-1355 42 13 sd sd NOUN dti-1355 42 14 ) ) PUNCT dti-1355 42 15 , , PUNCT dti-1355 42 16 or or CCONJ dti-1355 42 17 as as ADP dti-1355 42 18 medians median NOUN dti-1355 42 19 and and CCONJ dti-1355 42 20 interquartile interquartile NOUN dti-1355 42 21 ranges range NOUN dti-1355 42 22 ( ( PUNCT dti-1355 42 23 ir ir NOUN dti-1355 42 24 ) ) PUNCT dti-1355 42 25 for for ADP dti-1355 42 26 variables variable NOUN dti-1355 42 27 with with ADP dti-1355 42 28 a a DET dti-1355 42 29 skewed skewed ADJ dti-1355 42 30 distribution distribution NOUN dti-1355 42 31 . . PUNCT dti-1355 43 1 a a DET dti-1355 43 2 repeated repeat VERB dti-1355 43 3 measures measure NOUN dti-1355 43 4 analysis analysis NOUN dti-1355 43 5 of of ADP dti-1355 43 6 variance variance NOUN dti-1355 43 7 combined combine VERB dti-1355 43 8 with with ADP dti-1355 43 9 fisher fisher PROPN dti-1355 43 10 ’s ’s PART dti-1355 43 11 protected protect VERB dti-1355 43 12 least least ADV dti-1355 43 13 significant significant ADJ dti-1355 43 14 difference difference NOUN dti-1355 43 15 test test NOUN dti-1355 43 16 for for ADP dti-1355 43 17 normal normal ADJ dti-1355 43 18 distributions distribution NOUN dti-1355 43 19 and and CCONJ dti-1355 43 20 the the DET dti-1355 43 21 kruskal kruskal NOUN dti-1355 43 22 – – PUNCT dti-1355 43 23 wallis wallis PROPN dti-1355 43 24 test test NOUN dti-1355 43 25 with with ADP dti-1355 43 26 dunn dunn PROPN dti-1355 43 27 ’s ’s PART dti-1355 43 28 method method NOUN dti-1355 43 29 for for ADP dti-1355 43 30 skewed skewed ADJ dti-1355 43 31 distributions distribution NOUN dti-1355 43 32 were be AUX dti-1355 43 33 used use VERB dti-1355 43 34 to to PART dti-1355 43 35 compare compare VERB dti-1355 43 36 the the DET dti-1355 43 37 time time NOUN dti-1355 43 38 course course NOUN dti-1355 43 39 data data NOUN dti-1355 43 40 , , PUNCT dti-1355 43 41 when when SCONJ dti-1355 43 42 appropriate appropriate ADJ dti-1355 43 43 . . PUNCT dti-1355 44 1 values value NOUN dti-1355 44 2 of of ADP dti-1355 44 3 p p PROPN dti-1355 44 4   PROPN dti-1355 44 5 0.05 0.05 NUM dti-1355 44 6     SPACE dti-1355 44 7 were be AUX dti-1355 44 8 considered consider VERB dti-1355 44 9 to to PART dti-1355 44 10 be be AUX dti-1355 44 11 statistically statistically ADV dti-1355 44 12 significant significant ADJ dti-1355 44 13 . . PUNCT dti-1355 45 1 the the DET dti-1355 45 2 statistical statistical ADJ dti-1355 45 3 analyses analysis NOUN dti-1355 45 4 were be AUX dti-1355 45 5 performed perform VERB dti-1355 45 6 using use VERB dti-1355 45 7 the the DET dti-1355 45 8 sigmaplot sigmaplot ADJ dti-1355 45 9 12 12 NUM dti-1355 45 10     SPACE dti-1355 45 11 software software NOUN dti-1355 45 12 program program NOUN dti-1355 45 13 for for ADP dti-1355 45 14 windows window NOUN dti-1355 45 15 ( ( PUNCT dti-1355 45 16 systat systat PROPN dti-1355 45 17 software software PROPN dti-1355 45 18 , , PUNCT dti-1355 45 19 inc inc PROPN dti-1355 45 20 . . PROPN dti-1355 45 21 , , PUNCT dti-1355 45 22 san san PROPN dti-1355 45 23 jose jose PROPN dti-1355 45 24 , , PUNCT dti-1355 45 25 ca ca NOUN dti-1355 45 26 ) ) PUNCT dti-1355 45 27 unless unless SCONJ dti-1355 45 28 otherwise otherwise ADV dti-1355 45 29 stated state VERB dti-1355 45 30 . . PUNCT dti-1355 46 1 results result NOUN dti-1355 46 2 and and CCONJ dti-1355 46 3 discussion discussion NOUN dti-1355 46 4 the the DET dti-1355 46 5 demographic demographic ADJ dti-1355 46 6 profiles profile NOUN dti-1355 46 7 of of ADP dti-1355 46 8 the the DET dti-1355 46 9 17 17 NUM dti-1355 46 10     SPACE dti-1355 46 11 patients patient NOUN dti-1355 46 12 included include VERB dti-1355 46 13 in in ADP dti-1355 46 14 the the DET dti-1355 46 15 present present ADJ dti-1355 46 16 study study NOUN dti-1355 46 17 are be AUX dti-1355 46 18 summarized summarize VERB dti-1355 46 19 in in ADP dti-1355 46 20 table table NOUN dti-1355 46 21 1 1 NUM dti-1355 46 22 . . PUNCT dti-1355 47 1 no no DET dti-1355 47 2 subjects subject NOUN dti-1355 47 3 had have VERB dti-1355 47 4 a a DET dti-1355 47 5 history history NOUN dti-1355 47 6 of of ADP dti-1355 47 7 gouty gouty ADJ dti-1355 47 8 attacks attack NOUN dti-1355 47 9 . . PUNCT dti-1355 48 1 the the DET dti-1355 48 2 patients patient NOUN dti-1355 48 3 had have AUX dti-1355 48 4 been be AUX dti-1355 48 5 treated treat VERB dti-1355 48 6 with with ADP dti-1355 48 7 chronic chronic ADJ dti-1355 48 8 hd hd NOUN dti-1355 48 9 for for ADP dti-1355 48 10 a a DET dti-1355 48 11 median median NOUN dti-1355 48 12 of of ADP dti-1355 48 13 four four NUM dti-1355 48 14 years year NOUN dti-1355 48 15 . . PUNCT dti-1355 49 1 the the DET dti-1355 49 2 causes cause NOUN dti-1355 49 3 of of ADP dti-1355 49 4 advanced advanced ADJ dti-1355 49 5 ckd ckd PROPN dti-1355 49 6 included include VERB dti-1355 49 7 diabetic diabetic ADJ dti-1355 49 8 nephropathy nephropathy NOUN dti-1355 49 9 , , PUNCT dti-1355 49 10 chronic chronic ADJ dti-1355 49 11 glomerulonephritis glomerulonephritis NOUN dti-1355 49 12 , , PUNCT dti-1355 49 13 hypertensive hypertensive ADJ dti-1355 49 14 nephrosclerosis nephrosclerosis NOUN dti-1355 49 15 , , PUNCT dti-1355 49 16 and and CCONJ dti-1355 49 17 polycystic polycystic ADJ dti-1355 49 18 kidney kidney NOUN dti-1355 49 19 disease disease NOUN dti-1355 49 20 . . PUNCT dti-1355 50 1 all all DET dti-1355 50 2 subjects subject NOUN dti-1355 50 3 were be AUX dti-1355 50 4 on on ADP dti-1355 50 5 the the DET dti-1355 50 6 optimum optimum ADJ dti-1355 50 7 tolerated tolerate VERB dti-1355 50 8 medical medical ADJ dti-1355 50 9 management management NOUN dti-1355 50 10 . . PUNCT dti-1355 51 1 febuxostat febuxostat NOUN dti-1355 51 2 lowered lower VERB dti-1355 51 3 the the DET dti-1355 51 4 serum serum PROPN dti-1355 51 5 ua ua PROPN dti-1355 51 6 levels level NOUN dti-1355 51 7 ( ( PUNCT dti-1355 51 8 8.9 8.9 NUM dti-1355 51 9     SPACE dti-1355 51 10 ± ± NOUN dti-1355 51 11 1.0 1.0 NUM dti-1355 51 12     SPACE dti-1355 51 13 at at ADP dti-1355 51 14 baseline baseline NOUN dti-1355 51 15 ) ) PUNCT dti-1355 51 16 significantly significantly ADV dti-1355 51 17 from from ADP dti-1355 51 18 one one NUM dti-1355 51 19 month month NOUN dti-1355 51 20 after after ADP dti-1355 51 21 the the DET dti-1355 51 22 initiation initiation NOUN dti-1355 51 23 of of ADP dti-1355 51 24 the the DET dti-1355 51 25 treatment treatment NOUN dti-1355 51 26 ( ( PUNCT dti-1355 51 27 fig fig NOUN dti-1355 51 28 . . NOUN dti-1355 51 29 1 1 NUM dti-1355 51 30 ) ) PUNCT dti-1355 51 31 , , PUNCT dti-1355 51 32 and and CCONJ dti-1355 51 33 the the DET dti-1355 51 34 target target NOUN dti-1355 51 35 serum serum NOUN dti-1355 51 36 ua ua PROPN dti-1355 51 37 level level NOUN dti-1355 51 38 ( ( PUNCT dti-1355 51 39 6.0 6.0 NOUN dti-1355 51 40     SPACE dti-1355 51 41 mg mg PROPN dti-1355 51 42 / / SYM dti-1355 51 43 dl dl PROPN dti-1355 51 44 ) ) PUNCT dti-1355 51 45 was be AUX dti-1355 51 46 achieved achieve VERB dti-1355 51 47 in in ADP dti-1355 51 48 12 12 NUM dti-1355 51 49     SPACE dti-1355 51 50 patients patient NOUN dti-1355 51 51 ( ( PUNCT dti-1355 51 52 70.5 70.5 NUM dti-1355 51 53 % % NOUN dti-1355 51 54 ) ) PUNCT dti-1355 51 55 after after ADP dti-1355 51 56 one one NUM dti-1355 51 57 month month NOUN dti-1355 51 58 of of ADP dti-1355 51 59 treatment treatment NOUN dti-1355 51 60 , , PUNCT dti-1355 51 61 compared compare VERB dti-1355 51 62 to to ADP dti-1355 51 63 13 13 NUM dti-1355 51 64     SPACE dti-1355 51 65 ( ( PUNCT dti-1355 51 66 76.4 76.4 NUM dti-1355 51 67 % % NOUN dti-1355 51 68 ) ) PUNCT dti-1355 51 69 and and CCONJ dti-1355 51 70 14 14 NUM dti-1355 51 71     SPACE dti-1355 51 72 ( ( PUNCT dti-1355 51 73 82.3 82.3 NUM dti-1355 51 74 % % NOUN dti-1355 51 75 ) ) PUNCT dti-1355 51 76 patients patient NOUN dti-1355 51 77 after after ADP dti-1355 51 78 three three NUM dti-1355 51 79 and and CCONJ dti-1355 51 80 six six NUM dti-1355 51 81 months month NOUN dti-1355 51 82 of of ADP dti-1355 51 83 treatment treatment NOUN dti-1355 51 84 , , PUNCT dti-1355 51 85 respectively respectively ADV dti-1355 51 86 . . PUNCT dti-1355 52 1 after after ADP dti-1355 52 2 six six NUM dti-1355 52 3 months month NOUN dti-1355 52 4 , , PUNCT dti-1355 52 5 16 16 NUM dti-1355 52 6     SPACE dti-1355 52 7 subjects subject NOUN dti-1355 52 8 were be AUX dti-1355 52 9 still still ADV dti-1355 52 10 under under ADP dti-1355 52 11 the the DET dti-1355 52 12 treatment treatment NOUN dti-1355 52 13 with with ADP dti-1355 52 14 oral oral ADJ dti-1355 52 15 febuxostat febuxostat NOUN dti-1355 52 16 ( ( PUNCT dti-1355 52 17 10 10 NUM dti-1355 52 18     SPACE dti-1355 52 19 mg mg PROPN dti-1355 52 20 / / SYM dti-1355 52 21 day day NOUN dti-1355 52 22 ) ) PUNCT dti-1355 52 23 , , PUNCT dti-1355 52 24 and and CCONJ dti-1355 52 25 there there PRON dti-1355 52 26 was be VERB dti-1355 52 27 table table NOUN dti-1355 52 28 1 1 NUM dti-1355 52 29 . . PUNCT dti-1355 52 30 demographic demographic ADJ dti-1355 52 31 profiles profile NOUN dti-1355 52 32 of of ADP dti-1355 52 33 the the DET dti-1355 52 34 patients patient NOUN dti-1355 52 35 at at ADP dti-1355 52 36 the the DET dti-1355 52 37 start start NOUN dti-1355 52 38 of of ADP dti-1355 52 39 the the DET dti-1355 52 40 study study NOUN dti-1355 52 41 . . PUNCT dti-1355 53 1 demographic demographic ADJ dti-1355 53 2 characteristics characteristic NOUN dti-1355 53 3 age age NOUN dti-1355 53 4 ( ( PUNCT dti-1355 53 5 years year NOUN dti-1355 53 6 ) ) PUNCT dti-1355 53 7 64 64 NUM dti-1355 53 8 ± ± NUM dti-1355 53 9 10 10 NUM dti-1355 53 10 sex sex NOUN dti-1355 53 11 ( ( PUNCT dti-1355 53 12 male male NOUN dti-1355 53 13 / / SYM dti-1355 53 14 female female NOUN dti-1355 53 15 ) ) PUNCT dti-1355 53 16 15/2 15/2 NUM dti-1355 53 17 hd hd NOUN dti-1355 53 18 duration duration NOUN dti-1355 53 19 ( ( PUNCT dti-1355 53 20 years year NOUN dti-1355 53 21 ) ) PUNCT dti-1355 53 22 6.4 6.4 NUM dti-1355 53 23 ± ± NUM dti-1355 53 24 5.7 5.7 NUM dti-1355 53 25 underlying underlying ADJ dti-1355 53 26 causes cause NOUN dti-1355 53 27 of of ADP dti-1355 53 28 ckd ckd PROPN dti-1355 53 29 , , PUNCT dti-1355 53 30 n n PROPN dti-1355 53 31 ( ( PUNCT dti-1355 53 32 % % INTJ dti-1355 53 33 ) ) PUNCT dti-1355 53 34 diabetic diabetic ADJ dti-1355 53 35 nephropathy nephropathy NOUN dti-1355 53 36 9 9 NUM dti-1355 53 37 ( ( PUNCT dti-1355 53 38 53 53 NUM dti-1355 53 39 ) ) PUNCT dti-1355 53 40 chronic chronic ADJ dti-1355 53 41 glomerulonephritis glomerulonephritis NOUN dti-1355 53 42 3 3 NUM dti-1355 53 43 ( ( PUNCT dti-1355 53 44 18 18 NUM dti-1355 53 45 ) ) PUNCT dti-1355 53 46 hypertensive hypertensive ADJ dti-1355 53 47 nephrosclerosis nephrosclerosis NOUN dti-1355 53 48 3 3 NUM dti-1355 53 49 ( ( PUNCT dti-1355 53 50 18 18 NUM dti-1355 53 51 ) ) PUNCT dti-1355 53 52 polycystic polycystic ADJ dti-1355 53 53 kidney kidney NOUN dti-1355 53 54 disease disease NOUN dti-1355 53 55 2 2 NUM dti-1355 53 56 ( ( PUNCT dti-1355 53 57 12 12 NUM dti-1355 53 58 ) ) PUNCT dti-1355 53 59 medications medication NOUN dti-1355 53 60 , , PUNCT dti-1355 53 61 n n CCONJ dti-1355 53 62 ( ( PUNCT dti-1355 53 63 % % INTJ dti-1355 53 64 ) ) PUNCT dti-1355 53 65 calcium calcium NOUN dti-1355 53 66 channel channel NOUN dti-1355 53 67 antagonist(s antagonist(s PROPN dti-1355 53 68 ) ) PUNCT dti-1355 53 69 7 7 NUM dti-1355 53 70 ( ( PUNCT dti-1355 53 71 41 41 NUM dti-1355 53 72 ) ) PUNCT dti-1355 53 73 angiotensin angiotensin NOUN dti-1355 53 74 - - PUNCT dti-1355 53 75 converting convert VERB dti-1355 53 76 - - PUNCT dti-1355 53 77 enzyme enzyme NOUN dti-1355 53 78 inhibitor inhibitor NOUN dti-1355 53 79 1 1 NUM dti-1355 53 80 ( ( PUNCT dti-1355 53 81 6 6 NUM dti-1355 53 82 ) ) PUNCT dti-1355 53 83 angiotensin angiotensin NOUN dti-1355 53 84 receptor receptor NOUN dti-1355 53 85 blocker(s blocker(s PROPN dti-1355 53 86 ) ) PUNCT dti-1355 53 87 7 7 NUM dti-1355 53 88 ( ( PUNCT dti-1355 53 89 41 41 NUM dti-1355 53 90 ) ) PUNCT dti-1355 53 91 renin renin ADJ dti-1355 53 92 inhibitor inhibitor NOUN dti-1355 53 93 1 1 NUM dti-1355 53 94 ( ( PUNCT dti-1355 53 95 6 6 NUM dti-1355 53 96 ) ) PUNCT dti-1355 53 97 other other ADJ dti-1355 53 98 anti anti ADJ dti-1355 53 99 - - ADJ dti-1355 53 100 hypertensive hypertensive ADJ dti-1355 53 101 agent(s agent(s PROPN dti-1355 53 102 ) ) PUNCT dti-1355 53 103 4 4 NUM dti-1355 53 104 ( ( PUNCT dti-1355 53 105 24 24 NUM dti-1355 53 106 ) ) PUNCT dti-1355 53 107 loop loop NOUN dti-1355 53 108 diuretic(s diuretic(s ADJ dti-1355 53 109 ) ) PUNCT dti-1355 53 110 3 3 NUM dti-1355 53 111 ( ( PUNCT dti-1355 53 112 18 18 NUM dti-1355 53 113 ) ) PUNCT dti-1355 53 114 http://www.la-press.com http://www.la-press.com X dti-1355 53 115 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 NOUN dti-1355 53 116 febuxostat febuxostat NOUN dti-1355 53 117 and and CCONJ dti-1355 53 118 advanced advanced ADJ dti-1355 53 119 chronic chronic ADJ dti-1355 53 120 kidney kidney NOUN dti-1355 53 121 disease disease NOUN dti-1355 53 122 patients patient NOUN dti-1355 53 123 41drug 41drug PROPN dti-1355 53 124 target target NOUN dti-1355 53 125 insights insight VERB dti-1355 53 126 2014:8 2014:8 NUM dti-1355 53 127 one one NUM dti-1355 53 128 subject subject NOUN dti-1355 53 129 who who PRON dti-1355 53 130 was be AUX dti-1355 53 131 being be AUX dti-1355 53 132 treated treat VERB dti-1355 53 133 with with ADP dti-1355 53 134 a a DET dti-1355 53 135 reduced reduced ADJ dti-1355 53 136 dose dose NOUN dti-1355 53 137 of of ADP dti-1355 53 138 5 5 NUM dti-1355 53 139     SPACE dti-1355 53 140 mg mg PROPN dti-1355 53 141 / / SYM dti-1355 53 142 day day NOUN dti-1355 53 143 . . PUNCT dti-1355 54 1 also also ADV dti-1355 54 2 , , PUNCT dti-1355 54 3 only only ADV dti-1355 54 4 two two NUM dti-1355 54 5 patients patient NOUN dti-1355 54 6 were be AUX dti-1355 54 7 treated treat VERB dti-1355 54 8 with with ADP dti-1355 54 9 the the DET dti-1355 54 10 agent agent NOUN dti-1355 54 11 at at ADP dti-1355 54 12 a a DET dti-1355 54 13 dose dose NOUN dti-1355 54 14 of of ADP dti-1355 54 15 above above ADP dti-1355 54 16 10 10 NUM dti-1355 54 17     SPACE dti-1355 54 18 mg mg PROPN dti-1355 54 19 / / SYM dti-1355 54 20 day day NOUN dti-1355 54 21 at at ADP dti-1355 54 22 that that DET dti-1355 54 23 point point NOUN dti-1355 54 24 , , PUNCT dti-1355 54 25 one one NUM dti-1355 54 26 with with ADP dti-1355 54 27 20 20 NUM dti-1355 54 28     SPACE dti-1355 54 29 mg mg PROPN dti-1355 54 30 / / SYM dti-1355 54 31 day day NOUN dti-1355 54 32 and and CCONJ dti-1355 54 33 one one NUM dti-1355 54 34 with with ADP dti-1355 54 35 40 40 NUM dti-1355 54 36     SPACE dti-1355 54 37 mg mg PROPN dti-1355 54 38 / / SYM dti-1355 54 39 day day NOUN dti-1355 54 40 . . PUNCT dti-1355 55 1 all all DET dti-1355 55 2 doses dose NOUN dti-1355 55 3 of of ADP dti-1355 55 4 febuxostat febuxostat NOUN dti-1355 55 5 were be AUX dti-1355 55 6 well well ADV dti-1355 55 7 tolerated tolerate VERB dti-1355 55 8 by by ADP dti-1355 55 9 the the DET dti-1355 55 10 patients patient NOUN dti-1355 55 11 with with ADP dti-1355 55 12 no no DET dti-1355 55 13 withdrawals withdrawal NOUN dti-1355 55 14 because because SCONJ dti-1355 55 15 of of ADP dti-1355 55 16 side side NOUN dti-1355 55 17 effects effect NOUN dti-1355 55 18 or or CCONJ dti-1355 55 19 allergic allergic ADJ dti-1355 55 20 reactions reaction NOUN dti-1355 55 21 . . PUNCT dti-1355 56 1 although although SCONJ dti-1355 56 2 there there PRON dti-1355 56 3 was be VERB dti-1355 56 4 a a DET dti-1355 56 5 significant significant ADJ dti-1355 56 6 increase increase NOUN dti-1355 56 7 in in ADP dti-1355 56 8 the the DET dti-1355 56 9 systolic systolic ADJ dti-1355 56 10 bp bp PROPN dti-1355 56 11 values value NOUN dti-1355 56 12 obtained obtain VERB dti-1355 56 13 at at ADP dti-1355 56 14 five five NUM dti-1355 56 15 and and CCONJ dti-1355 56 16 six six NUM dti-1355 56 17 months month NOUN dti-1355 56 18 compared compare VERB dti-1355 56 19 to to ADP dti-1355 56 20 those those PRON dti-1355 56 21 observed observe VERB dti-1355 56 22 at at ADP dti-1355 56 23 baseline baseline NOUN dti-1355 56 24 , , PUNCT dti-1355 56 25 no no DET dti-1355 56 26 significant significant ADJ dti-1355 56 27 changes change NOUN dti-1355 56 28 in in ADP dti-1355 56 29 diastolic diastolic ADJ dti-1355 56 30 bp bp PROPN dti-1355 56 31 , , PUNCT dti-1355 56 32 hb hb PROPN dti-1355 56 33 , , PUNCT dti-1355 56 34 hct hct PROPN dti-1355 56 35 , , PUNCT dti-1355 56 36 plt plt PROPN dti-1355 56 37 , , PUNCT dti-1355 56 38 bun bun NOUN dti-1355 56 39 , , PUNCT dti-1355 56 40 or or CCONJ dti-1355 56 41 the the DET dti-1355 56 42 serum serum NOUN dti-1355 56 43 levels level NOUN dti-1355 56 44 of of ADP dti-1355 56 45 cr cr PROPN dti-1355 56 46 , , PUNCT dti-1355 56 47 na na NOUN dti-1355 56 48 , , PUNCT dti-1355 56 49 cl cl NOUN dti-1355 56 50 , , PUNCT dti-1355 56 51 k k NOUN dti-1355 56 52 , , PUNCT dti-1355 56 53 ca ca NOUN dti-1355 56 54 , , PUNCT dti-1355 56 55 pi pi NOUN dti-1355 56 56 , , PUNCT dti-1355 56 57 ast ast ADJ dti-1355 56 58 , , PUNCT dti-1355 56 59 alt alt ADJ dti-1355 56 60 , , PUNCT dti-1355 56 61 or or CCONJ dti-1355 56 62 ldh ldh PROPN dti-1355 56 63 were be AUX dti-1355 56 64 noted note VERB dti-1355 56 65 during during ADP dti-1355 56 66 the the DET dti-1355 56 67 observation observation NOUN dti-1355 56 68 period period NOUN dti-1355 56 69 ( ( PUNCT dti-1355 56 70 table table NOUN dti-1355 56 71 2 2 NUM dti-1355 56 72 ) ) PUNCT dti-1355 56 73 . . PUNCT dti-1355 57 1 there there PRON dti-1355 57 2 were be VERB dti-1355 57 3 similar similar ADJ dti-1355 57 4 trends trend NOUN dti-1355 57 5 in in ADP dti-1355 57 6 the the DET dti-1355 57 7 serum serum NOUN dti-1355 57 8 levels level NOUN dti-1355 57 9 of of ADP dti-1355 57 10 protein protein NOUN dti-1355 57 11 carbonyls carbonyls NOUN dti-1355 57 12 and and CCONJ dti-1355 57 13 3 3 NUM dti-1355 57 14 - - PUNCT dti-1355 57 15 nt not PART dti-1355 57 16 , , PUNCT dti-1355 57 17 while while SCONJ dti-1355 57 18 the the DET dti-1355 57 19 serum serum NOUN dti-1355 57 20 8 8 NUM dti-1355 57 21 - - PUNCT dti-1355 57 22 ohdg ohdg NOUN dti-1355 57 23 levels level NOUN dti-1355 57 24 measured measure VERB dti-1355 57 25 after after ADP dti-1355 57 26 six six NUM dti-1355 57 27 months month NOUN dti-1355 57 28 were be AUX dti-1355 57 29 significantly significantly ADV dti-1355 57 30 lower low ADJ dti-1355 57 31 than than ADP dti-1355 57 32 those those PRON dti-1355 57 33 at at ADP dti-1355 57 34 the the DET dti-1355 57 35 baseline baseline NOUN dti-1355 57 36 ( ( PUNCT dti-1355 57 37 table table NOUN dti-1355 57 38 3 3 NUM dti-1355 57 39 ) ) PUNCT dti-1355 57 40 . . PUNCT dti-1355 58 1 no no DET dti-1355 58 2 patients patient NOUN dti-1355 58 3 experienced experience VERB dti-1355 58 4 symptoms symptom NOUN dti-1355 58 5 of of ADP dti-1355 58 6 gouty gouty ADJ dti-1355 58 7 arthritis arthritis NOUN dti-1355 58 8 , , PUNCT dti-1355 58 9 including include VERB dti-1355 58 10 joint joint ADJ dti-1355 58 11 pain pain NOUN dti-1355 58 12 , , PUNCT dti-1355 58 13 swelling swelling NOUN dti-1355 58 14 , , PUNCT dti-1355 58 15 or or CCONJ dti-1355 58 16 redness,2 redness,2 NOUN dti-1355 58 17 during during ADP dti-1355 58 18 the the DET dti-1355 58 19 observation observation NOUN dti-1355 58 20 period period NOUN dti-1355 58 21 . . PUNCT dti-1355 59 1 the the DET dti-1355 59 2 treatment treatment NOUN dti-1355 59 3 of of ADP dti-1355 59 4 patients patient NOUN dti-1355 59 5 with with ADP dti-1355 59 6 asymptomatic asymptomatic ADJ dti-1355 59 7 hyperuricemia hyperuricemia NOUN dti-1355 59 8 ( ( PUNCT dti-1355 59 9 a a DET dti-1355 59 10 serum serum NOUN dti-1355 59 11 ua ua NOUN dti-1355 59 12 level level NOUN dti-1355 59 13 higher high ADJ dti-1355 59 14 than than ADP dti-1355 59 15 8 8 NUM dti-1355 59 16     SPACE dti-1355 59 17 mg mg PROPN dti-1355 59 18 / / SYM dti-1355 59 19 dl dl PROPN dti-1355 59 20 ) ) PUNCT dti-1355 59 21 with with ADP dti-1355 59 22 urate urate NOUN dti-1355 59 23 lowering lower VERB dti-1355 59 24 agents agent NOUN dti-1355 59 25 has have AUX dti-1355 59 26 been be AUX dti-1355 59 27 recommended recommend VERB dti-1355 59 28 and and CCONJ dti-1355 59 29 applied apply VERB dti-1355 59 30 in in ADP dti-1355 59 31 japan,7,11 japan,7,11 PROPN dti-1355 59 32     SPACE dti-1355 59 33 while while SCONJ dti-1355 59 34 the the DET dti-1355 59 35 appropriate appropriate ADJ dti-1355 59 36 dose dose NOUN dti-1355 59 37 of of ADP dti-1355 59 38 febuxostat febuxostat NOUN dti-1355 59 39 among among ADP dti-1355 59 40 subjects subject NOUN dti-1355 59 41 with with ADP dti-1355 59 42 advanced advanced ADJ dti-1355 59 43 ckd ckd PROPN dti-1355 59 44 has have AUX dti-1355 59 45 not not PART dti-1355 59 46 yet yet ADV dti-1355 59 47 been be AUX dti-1355 59 48 established establish VERB dti-1355 59 49 . . PUNCT dti-1355 60 1 the the DET dti-1355 60 2 current current ADJ dti-1355 60 3 observations observation NOUN dti-1355 60 4 suggest suggest VERB dti-1355 60 5 that that SCONJ dti-1355 60 6 even even ADV dti-1355 60 7 relatively relatively ADV dti-1355 60 8 low low ADJ dti-1355 60 9 doses dose NOUN dti-1355 60 10 of of ADP dti-1355 60 11 febuxostat febuxostat NOUN dti-1355 60 12 , , PUNCT dti-1355 60 13 which which PRON dti-1355 60 14 is be AUX dti-1355 60 15 approved approve VERB dti-1355 60 16 at at ADP dti-1355 60 17 a a DET dti-1355 60 18 dose dose NOUN dti-1355 60 19 of of ADP dti-1355 60 20 40 40 NUM dti-1355 60 21     SPACE dti-1355 60 22 to to ADP dti-1355 60 23 60 60 NUM dti-1355 60 24     SPACE dti-1355 60 25 mg mg PROPN dti-1355 60 26 / / SYM dti-1355 60 27 day day NOUN dti-1355 60 28 as as SCONJ dti-1355 60 29 the the DET dti-1355 60 30 standard standard NOUN dti-1355 60 31 dose dose VERB dti-1355 60 32 for for ADP dti-1355 60 33 the the DET dti-1355 60 34 treatment treatment NOUN dti-1355 60 35 of of ADP dti-1355 60 36 hyperuricemia hyperuricemia NOUN dti-1355 60 37 with with ADP dti-1355 60 38 or or CCONJ dti-1355 60 39 without without ADP dti-1355 60 40 gouty gouty ADJ dti-1355 60 41 arthritis arthritis NOUN dti-1355 60 42 in in ADP dti-1355 60 43 japan japan PROPN dti-1355 60 44 , , PUNCT dti-1355 60 45 may may AUX dti-1355 60 46 also also ADV dti-1355 60 47 work work VERB dti-1355 60 48 effectively effectively ADV dti-1355 60 49 among among ADP dti-1355 60 50 chronic chronic ADJ dti-1355 60 51 hd hd NOUN dti-1355 60 52 patients patient NOUN dti-1355 60 53 for for ADP dti-1355 60 54 reducing reduce VERB dti-1355 60 55 the the DET dti-1355 60 56 serum serum NOUN dti-1355 60 57 ua ua PROPN dti-1355 60 58 to to ADP dti-1355 60 59 a a DET dti-1355 60 60 level level NOUN dti-1355 60 61 that that PRON dti-1355 60 62 has have AUX dti-1355 60 63 been be AUX dti-1355 60 64 arbitrarily arbitrarily ADV dti-1355 60 65 proposed propose VERB dti-1355 60 66 as as ADP dti-1355 60 67 a a DET dti-1355 60 68 therapeutic therapeutic ADJ dti-1355 60 69 target target NOUN dti-1355 60 70 for for ADP dti-1355 60 71 hyperuricemia.7,11,12 hyperuricemia.7,11,12 NOUN dti-1355 60 72     SPACE dti-1355 60 73 the the DET dti-1355 60 74 validity validity NOUN dti-1355 60 75 of of ADP dti-1355 60 76 the the DET dti-1355 60 77 indications indication NOUN dti-1355 60 78 for for ADP dti-1355 60 79 uratelowering uratelowere VERB dti-1355 60 80 agents agent NOUN dti-1355 60 81 among among ADP dti-1355 60 82 overall overall ADJ dti-1355 60 83 subjects subject NOUN dti-1355 60 84 with with ADP dti-1355 60 85 asymptomatic asymptomatic ADJ dti-1355 60 86 after after SCONJ dti-1355 60 87 the the DET dti-1355 60 88 treatment treatment NOUN dti-1355 60 89 with with ADP dti-1355 60 90 oral oral ADJ dti-1355 60 91 febuxostat febuxostat NOUN dti-1355 60 92 ( ( PUNCT dti-1355 60 93 month(s month(s NOUN dti-1355 60 94 ) ) PUNCT dti-1355 60 95 ) ) PUNCT dti-1355 60 96 baseline baseline VERB dti-1355 60 97 1 1 NUM dti-1355 60 98 4 4 NUM dti-1355 60 99 6 6 NUM dti-1355 60 100 8 8 NUM dti-1355 60 101 * * PUNCT dti-1355 60 102 * * PUNCT dti-1355 61 1 * * PUNCT dti-1355 61 2 * * PUNCT dti-1355 62 1 * * PUNCT dti-1355 62 2 * * PUNCT dti-1355 63 1 * * PUNCT dti-1355 63 2 * * PUNCT dti-1355 64 1 * * PUNCT dti-1355 64 2 * * PUNCT dti-1355 64 3 * * PUNCT dti-1355 64 4 * * PUNCT dti-1355 64 5 10 10 NUM dti-1355 64 6 12 12 NUM dti-1355 64 7 2 2 NUM dti-1355 64 8 3 3 NUM dti-1355 64 9 4 4 NUM dti-1355 64 10 5 5 NUM dti-1355 64 11 6 6 NUM dti-1355 64 12 u u NOUN dti-1355 64 13 a a PRON dti-1355 64 14 ( ( PUNCT dti-1355 64 15 m m NOUN dti-1355 64 16 g/ g/ NOUN dti-1355 64 17 dl dl NOUN dti-1355 64 18 ) ) PUNCT dti-1355 64 19 figure figure NOUN dti-1355 64 20 1 1 NUM dti-1355 64 21 . . PUNCT dti-1355 65 1 the the DET dti-1355 65 2 serum serum PROPN dti-1355 65 3 ua ua PROPN dti-1355 65 4 levels level NOUN dti-1355 65 5 before before ADP dti-1355 65 6 and and CCONJ dti-1355 65 7 after after ADP dti-1355 65 8 the the DET dti-1355 65 9 initiation initiation NOUN dti-1355 65 10 of of ADP dti-1355 65 11 the the DET dti-1355 65 12 treatment treatment NOUN dti-1355 65 13 with with ADP dti-1355 65 14 oral oral ADJ dti-1355 65 15 febuxostat febuxostat NOUN dti-1355 65 16 . . PUNCT dti-1355 66 1 after after ADP dti-1355 66 2 six six NUM dti-1355 66 3 months month NOUN dti-1355 66 4 of of ADP dti-1355 66 5 febuxostat febuxostat NOUN dti-1355 66 6 treatment treatment NOUN dti-1355 66 7 , , PUNCT dti-1355 66 8 the the DET dti-1355 66 9 serum serum PROPN dti-1355 66 10 ua ua PROPN dti-1355 66 11 levels level NOUN dti-1355 66 12 were be AUX dti-1355 66 13 significantly significantly ADV dti-1355 66 14 decreased decrease VERB dti-1355 66 15 from from ADP dti-1355 66 16 those those PRON dti-1355 66 17 at at ADP dti-1355 66 18 baseline baseline NOUN dti-1355 66 19 . . PUNCT dti-1355 67 1 all all DET dti-1355 67 2 patients patient NOUN dti-1355 67 3 were be AUX dti-1355 67 4 entered enter VERB dti-1355 67 5 into into ADP dti-1355 67 6 the the DET dti-1355 67 7 six six NUM dti-1355 67 8 - - PUNCT dti-1355 67 9 month month NOUN dti-1355 67 10 treatment treatment NOUN dti-1355 67 11 period period NOUN dti-1355 67 12 from from ADP dti-1355 67 13 july july PROPN dti-1355 67 14 through through ADP dti-1355 67 15 august august PROPN dti-1355 67 16 2012 2012 NUM dti-1355 67 17 . . PUNCT dti-1355 68 1 note note VERB dti-1355 68 2 that that SCONJ dti-1355 68 3 the the DET dti-1355 68 4 decrease decrease NOUN dti-1355 68 5 in in ADP dti-1355 68 6 the the DET dti-1355 68 7 serum serum NOUN dti-1355 68 8 ua ua PROPN dti-1355 68 9 levels level NOUN dti-1355 68 10 was be AUX dti-1355 68 11 already already ADV dti-1355 68 12 significant significant ADJ dti-1355 68 13 after after ADP dti-1355 68 14 one one NUM dti-1355 68 15 month month NOUN dti-1355 68 16 treatment treatment NOUN dti-1355 68 17 with with ADP dti-1355 68 18 febuxostat febuxostat NOUN dti-1355 68 19 . . PUNCT dti-1355 69 1 notes note NOUN dti-1355 69 2 : : PUNCT dti-1355 69 3 n n PROPN dti-1355 69 4 = = SYM dti-1355 69 5 17 17 NUM dti-1355 69 6 , , PUNCT dti-1355 69 7 * * PUNCT dti-1355 69 8 * * PUNCT dti-1355 69 9 p p NOUN dti-1355 69 10   PROPN dti-1355 69 11 0.01 0.01 NUM dti-1355 69 12 versus versus ADP dti-1355 69 13 baseline baseline NOUN dti-1355 69 14 . . PUNCT dti-1355 70 1 ta ta X dti-1355 70 2 bl bl PROPN dti-1355 70 3 e e PROPN dti-1355 70 4 2 2 NUM dti-1355 70 5 . . PUNCT dti-1355 71 1 c c NOUN dti-1355 71 2 ha ha INTJ dti-1355 71 3 ng ng PROPN dti-1355 71 4 es es NOUN dti-1355 71 5 in in ADP dti-1355 71 6 c c PROPN dti-1355 71 7 lin lin PROPN dti-1355 71 8 ic ic PROPN dti-1355 71 9 al al PROPN dti-1355 71 10 p p PROPN dti-1355 71 11 ar ar PROPN dti-1355 71 12 am be AUX dti-1355 71 13 et et NOUN dti-1355 71 14 er er INTJ dti-1355 71 15 s s X dti-1355 71 16 du du PROPN dti-1355 71 17 rin rin PROPN dti-1355 71 18 g g PROPN dti-1355 71 19 th th X dti-1355 71 20 e e X dti-1355 71 21 ob ob X dti-1355 71 22 se se PROPN dti-1355 71 23 rv rv PROPN dti-1355 71 24 at at ADP dti-1355 71 25 io io PROPN dti-1355 71 26 n n PROPN dti-1355 71 27 pe pe PROPN dti-1355 71 28 rio rio PROPN dti-1355 71 29 d. d. PROPN dti-1355 72 1 a a PRON dti-1355 72 2 ft ft INTJ dti-1355 72 3 er er INTJ dti-1355 72 4 t t NOUN dti-1355 72 5 h h NOUN dti-1355 72 6 e e NOUN dti-1355 72 7 in in ADP dti-1355 72 8 it it PRON dti-1355 72 9 ia ia VERB dti-1355 72 10 ti ti NOUN dti-1355 72 11 o o NOUN dti-1355 72 12 n n ADP dti-1355 72 13 o o NOUN dti-1355 72 14 f f X dti-1355 73 1 o o NOUN dti-1355 73 2 r r NOUN dti-1355 73 3 a a DET dti-1355 73 4 l l NOUN dti-1355 73 5 fe fe X dti-1355 73 6 b b X dti-1355 73 7 u u PROPN dti-1355 73 8 xo xo PROPN dti-1355 73 9 st st PROPN dti-1355 73 10 at at ADP dti-1355 73 11 t t PROPN dti-1355 73 12 r r NOUN dti-1355 73 13 e e PROPN dti-1355 73 14 at at ADP dti-1355 73 15 m m PROPN dti-1355 73 16 en en ADP dti-1355 73 17 t t PROPN dti-1355 73 18 p p PROPN dti-1355 73 19 va va PROPN dti-1355 74 1 lu lu PROPN dti-1355 74 2 e e PROPN dti-1355 74 3 b b PROPN dti-1355 74 4 a a PRON dti-1355 74 5 se se X dti-1355 74 6 li li PROPN dti-1355 74 7 n n PROPN dti-1355 74 8 e e PROPN dti-1355 74 9 1 1 NUM dti-1355 74 10 m m VERB dti-1355 74 11 o o NOUN dti-1355 74 12 n n ADV dti-1355 74 13 th th X dti-1355 74 14 2 2 NUM dti-1355 74 15 m m NOUN dti-1355 74 16 o o NOUN dti-1355 74 17 n n PRON dti-1355 74 18 th th X dti-1355 74 19 s s PROPN dti-1355 74 20 3 3 NUM dti-1355 74 21 m m NOUN dti-1355 74 22 o o NOUN dti-1355 74 23 n n ADV dti-1355 74 24 th th X dti-1355 74 25 s s PROPN dti-1355 74 26 4 4 NUM dti-1355 74 27 m m NOUN dti-1355 74 28 o o NOUN dti-1355 74 29 n n ADV dti-1355 74 30 th th X dti-1355 74 31 s s PROPN dti-1355 74 32 5 5 NUM dti-1355 74 33 m m NOUN dti-1355 74 34 o o NOUN dti-1355 74 35 n n ADV dti-1355 74 36 th th X dti-1355 74 37 s s PROPN dti-1355 74 38 6 6 NUM dti-1355 74 39 m m NOUN dti-1355 74 40 o o NOUN dti-1355 74 41 n n ADV dti-1355 74 42 th th X dti-1355 74 43 s s NOUN dti-1355 74 44 s s X dti-1355 74 45 ys ys NOUN dti-1355 74 46 to to ADP dti-1355 74 47 lic lic PROPN dti-1355 74 48 b b PROPN dti-1355 74 49 p p X dti-1355 74 50 ( ( PUNCT dti-1355 74 51 m m NOUN dti-1355 74 52 m m VERB dti-1355 74 53 h h NOUN dti-1355 74 54 g g NOUN dti-1355 74 55 ) ) PUNCT dti-1355 74 56 14 14 NUM dti-1355 74 57 1 1 NUM dti-1355 74 58 ± ± NUM dti-1355 74 59 20 20 NUM dti-1355 74 60 13 13 NUM dti-1355 74 61 7 7 NUM dti-1355 74 62 ± ± NUM dti-1355 74 63 16 16 NUM dti-1355 74 64 14 14 NUM dti-1355 74 65 1 1 NUM dti-1355 74 66 ± ± NUM dti-1355 74 67 29 29 NUM dti-1355 74 68 14 14 NUM dti-1355 74 69 1 1 NUM dti-1355 74 70 ± ± NUM dti-1355 74 71 16 16 NUM dti-1355 74 72 14 14 NUM dti-1355 74 73 2 2 NUM dti-1355 74 74 ± ± NUM dti-1355 74 75 21 21 NUM dti-1355 74 76 14 14 NUM dti-1355 74 77 8 8 NUM dti-1355 74 78 ± ± NUM dti-1355 74 79 21 21 NUM dti-1355 74 80 * * SYM dti-1355 74 81 14 14 NUM dti-1355 74 82 9 9 NUM dti-1355 74 83 ± ± NUM dti-1355 74 84 19 19 NUM dti-1355 74 85 * * PUNCT dti-1355 74 86   PROPN dti-1355 74 87 0 0 NUM dti-1355 74 88 . . PUNCT dti-1355 74 89 00 00 NUM dti-1355 75 1 1 1 NUM dti-1355 75 2 d d PROPN dti-1355 75 3 ia ia PROPN dti-1355 75 4 st st PROPN dti-1355 75 5 ol ol PROPN dti-1355 76 1 ic ic PROPN dti-1355 76 2 b b PROPN dti-1355 76 3 p p X dti-1355 76 4 ( ( PUNCT dti-1355 76 5 m m NOUN dti-1355 76 6 m m VERB dti-1355 76 7 h h NOUN dti-1355 76 8 g g NOUN dti-1355 76 9 ) ) PUNCT dti-1355 76 10 74 74 NUM dti-1355 76 11 ± ± NUM dti-1355 76 12 1 1 NUM dti-1355 76 13 1 1 NUM dti-1355 76 14 73 73 NUM dti-1355 76 15 ± ± NUM dti-1355 76 16 9 9 NUM dti-1355 76 17 73 73 NUM dti-1355 76 18 ± ± NUM dti-1355 76 19 1 1 NUM dti-1355 76 20 0 0 NUM dti-1355 76 21 76 76 NUM dti-1355 76 22 ± ± NUM dti-1355 76 23 1 1 NUM dti-1355 76 24 0 0 NUM dti-1355 76 25 76 76 NUM dti-1355 76 26 ± ± NUM dti-1355 76 27 1 1 NUM dti-1355 76 28 2 2 NUM dti-1355 76 29 74 74 NUM dti-1355 76 30 ± ± NUM dti-1355 76 31 1 1 NUM dti-1355 76 32 1 1 NUM dti-1355 76 33 73 73 NUM dti-1355 76 34 ± ± NUM dti-1355 76 35 1 1 NUM dti-1355 76 36 1 1 NUM dti-1355 76 37 0 0 NUM dti-1355 76 38 . . NOUN dti-1355 76 39 18 18 NUM dti-1355 76 40 6 6 NUM dti-1355 76 41 h h NOUN dti-1355 76 42 b b PROPN dti-1355 76 43 ( ( PUNCT dti-1355 76 44 g g PROPN dti-1355 76 45 /d /d SYM dti-1355 76 46 l l NOUN dti-1355 76 47 ) ) PUNCT dti-1355 77 1 10 10 NUM dti-1355 77 2 .7 .7 NUM dti-1355 77 3 ± ± NUM dti-1355 77 4 1 1 NUM dti-1355 77 5 .0 .0 NUM dti-1355 77 6 10 10 NUM dti-1355 77 7 .8 .8 NUM dti-1355 77 8 ± ± NUM dti-1355 77 9 1 1 NUM dti-1355 77 10 .0 .0 NUM dti-1355 77 11 10 10 NUM dti-1355 77 12 .9 .9 NUM dti-1355 77 13 ± ± NUM dti-1355 77 14 1 1 NUM dti-1355 77 15 .1 .1 NUM dti-1355 77 16 10 10 NUM dti-1355 77 17 .8 .8 NUM dti-1355 77 18 ± ± NUM dti-1355 77 19 1 1 NUM dti-1355 77 20 .6 .6 NUM dti-1355 77 21 10 10 NUM dti-1355 77 22 .9 .9 NUM dti-1355 77 23 ± ± NUM dti-1355 77 24 1 1 NUM dti-1355 77 25 .3 .3 NUM dti-1355 77 26 10 10 NUM dti-1355 77 27 .9 .9 NUM dti-1355 77 28 ± ± NUM dti-1355 77 29 1 1 NUM dti-1355 77 30 .3 .3 NUM dti-1355 77 31 10 10 NUM dti-1355 77 32 .6 .6 NUM dti-1355 77 33 ± ± NUM dti-1355 77 34 1 1 NUM dti-1355 77 35 .0 .0 NUM dti-1355 77 36 0 0 NUM dti-1355 77 37 . . PUNCT dti-1355 77 38 98 98 NUM dti-1355 77 39 9 9 NUM dti-1355 77 40 h h NOUN dti-1355 77 41 ct ct NOUN dti-1355 77 42 ( ( PUNCT dti-1355 77 43 % % NOUN dti-1355 77 44 ) ) PUNCT dti-1355 77 45 33 33 NUM dti-1355 77 46 .9 .9 NUM dti-1355 77 47 ± ± NUM dti-1355 77 48 3 3 NUM dti-1355 77 49 .1 .1 NUM dti-1355 77 50 33 33 NUM dti-1355 77 51 .9 .9 NUM dti-1355 77 52 ± ± NUM dti-1355 77 53 3 3 NUM dti-1355 77 54 .2 .2 NUM dti-1355 77 55 33 33 NUM dti-1355 77 56 .5 .5 NUM dti-1355 77 57 ± ± NUM dti-1355 77 58 3 3 NUM dti-1355 77 59 .4 .4 NUM dti-1355 77 60 34 34 NUM dti-1355 77 61 .1 .1 NUM dti-1355 77 62 ± ± NUM dti-1355 77 63 3 3 NUM dti-1355 77 64 .4 .4 NUM dti-1355 77 65 34 34 NUM dti-1355 77 66 .0 .0 NUM dti-1355 77 67 ± ± NUM dti-1355 77 68 4 4 NUM dti-1355 77 69 .3 .3 NUM dti-1355 77 70 34 34 NUM dti-1355 77 71 .0 .0 NUM dti-1355 77 72 ± ± NUM dti-1355 77 73 3 3 NUM dti-1355 77 74 .6 .6 NUM dti-1355 77 75 33 33 NUM dti-1355 77 76 .1 .1 NUM dti-1355 77 77 ± ± NUM dti-1355 77 78 2 2 NUM dti-1355 77 79 .9 .9 NUM dti-1355 77 80 0 0 NUM dti-1355 77 81 . . NUM dti-1355 77 82 97 97 NUM dti-1355 77 83 6 6 NUM dti-1355 77 84 p p NOUN dti-1355 77 85 lt lt PRON dti-1355 77 86 ( ( PUNCT dti-1355 77 87 × × PROPN dti-1355 77 88 10 10 NUM dti-1355 77 89 4 4 NUM dti-1355 77 90 /μ /μ SYM dti-1355 77 91 l l NOUN dti-1355 77 92 ) ) PUNCT dti-1355 77 93 16 16 NUM dti-1355 77 94 .8 .8 NUM dti-1355 78 1 ( ( PUNCT dti-1355 78 2 i i PRON dti-1355 78 3 r r VERB dti-1355 78 4 : : PUNCT dti-1355 78 5 1 1 NUM dti-1355 78 6 4 4 NUM dti-1355 78 7 . . NOUN dti-1355 78 8 2 2 NUM dti-1355 78 9 – – PUNCT dti-1355 78 10 22 22 NUM dti-1355 78 11 .7 .7 NUM dti-1355 78 12 ) ) PUNCT dti-1355 78 13 15 15 NUM dti-1355 79 1 .6 .6 NUM dti-1355 79 2 ( ( PUNCT dti-1355 79 3 i i PRON dti-1355 79 4 r r VERB dti-1355 79 5 : : PUNCT dti-1355 79 6 1 1 NUM dti-1355 79 7 3 3 NUM dti-1355 79 8 . . NOUN dti-1355 79 9 6 6 NUM dti-1355 79 10 – – PUNCT dti-1355 79 11 25 25 NUM dti-1355 79 12 .1 .1 NUM dti-1355 79 13 ) ) PUNCT dti-1355 79 14 17 17 NUM dti-1355 79 15 .8 .8 NUM dti-1355 80 1 ( ( PUNCT dti-1355 80 2 i i PRON dti-1355 80 3 r r VERB dti-1355 80 4 : : PUNCT dti-1355 80 5 1 1 NUM dti-1355 80 6 4 4 NUM dti-1355 80 7 . . NOUN dti-1355 80 8 2 2 NUM dti-1355 80 9 – – PUNCT dti-1355 80 10 24 24 NUM dti-1355 80 11 .6 .6 NUM dti-1355 80 12 ) ) PUNCT dti-1355 80 13 18 18 NUM dti-1355 80 14 .4 .4 NUM dti-1355 81 1 ( ( PUNCT dti-1355 81 2 i i PRON dti-1355 81 3 r r VERB dti-1355 81 4 : : PUNCT dti-1355 81 5 1 1 NUM dti-1355 81 6 4 4 NUM dti-1355 81 7 . . NOUN dti-1355 81 8 9 9 NUM dti-1355 81 9 – – PUNCT dti-1355 81 10 25 25 NUM dti-1355 81 11 .2 .2 NUM dti-1355 81 12 ) ) PUNCT dti-1355 81 13 17 17 NUM dti-1355 81 14 .7 .7 NUM dti-1355 82 1 ( ( PUNCT dti-1355 82 2 i i PRON dti-1355 82 3 r r VERB dti-1355 82 4 : : PUNCT dti-1355 82 5 1 1 NUM dti-1355 82 6 2 2 NUM dti-1355 82 7 . . NOUN dti-1355 82 8 8 8 NUM dti-1355 82 9 – – PUNCT dti-1355 82 10 23 23 NUM dti-1355 82 11 .1 .1 NUM dti-1355 82 12 ) ) PUNCT dti-1355 83 1 16 16 NUM dti-1355 83 2 .7 .7 NUM dti-1355 83 3 ( ( PUNCT dti-1355 83 4 i i PRON dti-1355 83 5 r r VERB dti-1355 83 6 : : PUNCT dti-1355 83 7 1 1 NUM dti-1355 83 8 2 2 NUM dti-1355 83 9 . . NOUN dti-1355 83 10 8 8 NUM dti-1355 83 11 – – PUNCT dti-1355 83 12 21 21 NUM dti-1355 83 13 .6 .6 NUM dti-1355 83 14 ) ) PUNCT dti-1355 83 15 18 18 NUM dti-1355 83 16 .3 .3 NUM dti-1355 83 17 ( ( PUNCT dti-1355 83 18 i i PRON dti-1355 83 19 r r VERB dti-1355 83 20 : : PUNCT dti-1355 83 21 1 1 NUM dti-1355 83 22 1 1 NUM dti-1355 83 23 . . X dti-1355 83 24 7 7 NUM dti-1355 83 25 – – PUNCT dti-1355 83 26 21 21 NUM dti-1355 83 27 .8 .8 NUM dti-1355 83 28 ) ) PUNCT dti-1355 83 29 0 0 NUM dti-1355 83 30 . . X dti-1355 83 31 88 88 NUM dti-1355 83 32 7 7 NUM dti-1355 83 33 b b X dti-1355 83 34 u u NOUN dti-1355 83 35 n n PROPN dti-1355 83 36 ( ( PUNCT dti-1355 83 37 m m NOUN dti-1355 83 38 g/ g/ NOUN dti-1355 83 39 dl dl PROPN dti-1355 83 40 ) ) PUNCT dti-1355 83 41 62 62 NUM dti-1355 83 42 .1 .1 NUM dti-1355 83 43 ± ± NOUN dti-1355 83 44 1 1 NUM dti-1355 83 45 1 1 NUM dti-1355 83 46 . . NUM dti-1355 83 47 7 7 NUM dti-1355 83 48 64 64 NUM dti-1355 83 49 .8 .8 NUM dti-1355 83 50 ± ± NUM dti-1355 83 51 1 1 NUM dti-1355 83 52 8 8 NUM dti-1355 83 53 . . NOUN dti-1355 83 54 6 6 NUM dti-1355 83 55 65 65 NUM dti-1355 83 56 .1 .1 NUM dti-1355 83 57 ± ± NUM dti-1355 83 58 1 1 NUM dti-1355 83 59 5 5 NUM dti-1355 83 60 . . NOUN dti-1355 83 61 8 8 NUM dti-1355 83 62 63 63 NUM dti-1355 83 63 .2 .2 NUM dti-1355 83 64 ± ± NUM dti-1355 83 65 1 1 NUM dti-1355 83 66 4 4 NUM dti-1355 83 67 . . NOUN dti-1355 83 68 1 1 NUM dti-1355 83 69 64 64 NUM dti-1355 83 70 .7 .7 NUM dti-1355 83 71 ± ± NUM dti-1355 83 72 1 1 NUM dti-1355 83 73 9 9 NUM dti-1355 83 74 . . SYM dti-1355 83 75 1 1 NUM dti-1355 83 76 67 67 NUM dti-1355 83 77 .0 .0 NUM dti-1355 83 78 ± ± NUM dti-1355 83 79 2 2 NUM dti-1355 83 80 1 1 NUM dti-1355 83 81 . . ADP dti-1355 83 82 4 4 NUM dti-1355 83 83 69 69 NUM dti-1355 83 84 .9 .9 NUM dti-1355 83 85 ± ± NUM dti-1355 83 86 1 1 NUM dti-1355 83 87 6 6 NUM dti-1355 83 88 . . ADP dti-1355 83 89 5 5 NUM dti-1355 83 90 0 0 NUM dti-1355 83 91 . . NOUN dti-1355 83 92 88 88 NUM dti-1355 83 93 6 6 NUM dti-1355 83 94 c c NOUN dti-1355 83 95 r r NOUN dti-1355 83 96 ( ( PUNCT dti-1355 83 97 m m NOUN dti-1355 83 98 g/ g/ NOUN dti-1355 83 99 dl dl PROPN dti-1355 83 100 ) ) PUNCT dti-1355 83 101 11 11 NUM dti-1355 83 102 .4 .4 NUM dti-1355 83 103 ± ± NUM dti-1355 83 104 1 1 NUM dti-1355 83 105 .9 .9 NUM dti-1355 83 106 11 11 NUM dti-1355 83 107 .8 .8 NUM dti-1355 83 108 ± ± NUM dti-1355 83 109 2 2 NUM dti-1355 83 110 .0 .0 NUM dti-1355 83 111 11 11 NUM dti-1355 83 112 .8 .8 NUM dti-1355 83 113 ± ± NUM dti-1355 83 114 1 1 NUM dti-1355 83 115 .9 .9 NUM dti-1355 83 116 11 11 NUM dti-1355 83 117 .8 .8 NUM dti-1355 83 118 ± ± NUM dti-1355 83 119 2 2 NUM dti-1355 83 120 .3 .3 NUM dti-1355 83 121 11 11 NUM dti-1355 83 122 .9 .9 NUM dti-1355 83 123 ± ± NUM dti-1355 83 124 2 2 NUM dti-1355 83 125 .2 .2 NUM dti-1355 83 126 11 11 NUM dti-1355 83 127 .5 .5 NUM dti-1355 83 128 ± ± NUM dti-1355 83 129 2 2 NUM dti-1355 83 130 .2 .2 NUM dti-1355 83 131 11 11 NUM dti-1355 83 132 .5 .5 NUM dti-1355 83 133 ± ± NUM dti-1355 83 134 2 2 NUM dti-1355 83 135 .2 .2 NUM dti-1355 83 136 0 0 NUM dti-1355 83 137 . . PUNCT dti-1355 84 1 99 99 NUM dti-1355 84 2 1 1 NUM dti-1355 84 3 n n NUM dti-1355 84 4 a a PRON dti-1355 84 5 ( ( PUNCT dti-1355 84 6 m m NOUN dti-1355 84 7 m m VERB dti-1355 84 8 ol ol ADJ dti-1355 84 9 /l /l PUNCT dti-1355 84 10 ) ) PUNCT dti-1355 84 11 13 13 NUM dti-1355 84 12 8 8 NUM dti-1355 84 13 ± ± NUM dti-1355 84 14 4 4 NUM dti-1355 84 15 13 13 NUM dti-1355 84 16 9 9 NUM dti-1355 84 17 ± ± NUM dti-1355 84 18 4 4 NUM dti-1355 84 19 14 14 NUM dti-1355 84 20 0 0 NUM dti-1355 84 21 ± ± NUM dti-1355 84 22 4 4 NUM dti-1355 84 23 13 13 NUM dti-1355 84 24 9 9 NUM dti-1355 84 25 ± ± NUM dti-1355 84 26 4 4 NUM dti-1355 84 27 13 13 NUM dti-1355 84 28 9 9 NUM dti-1355 84 29 ± ± NUM dti-1355 84 30 4 4 NUM dti-1355 84 31 13 13 NUM dti-1355 84 32 9 9 NUM dti-1355 84 33 ± ± NUM dti-1355 84 34 3 3 NUM dti-1355 84 35 13 13 NUM dti-1355 84 36 8 8 NUM dti-1355 84 37 ± ± NUM dti-1355 84 38 2 2 NUM dti-1355 84 39 0 0 NUM dti-1355 84 40 . . PUNCT dti-1355 84 41 80 80 NUM dti-1355 84 42 5 5 NUM dti-1355 84 43 k k X dti-1355 84 44 ( ( PUNCT dti-1355 84 45 m m VERB dti-1355 84 46 m m VERB dti-1355 84 47 ol ol ADJ dti-1355 84 48 /l /l PUNCT dti-1355 84 49 ) ) PUNCT dti-1355 84 50 4 4 NUM dti-1355 84 51 . . NOUN dti-1355 84 52 9 9 NUM dti-1355 84 53 ± ± NUM dti-1355 84 54 0 0 NUM dti-1355 84 55 . . PUNCT dti-1355 84 56 9 9 NUM dti-1355 84 57 4 4 NUM dti-1355 84 58 . . NOUN dti-1355 84 59 9 9 NUM dti-1355 84 60 ± ± NUM dti-1355 84 61 0 0 NUM dti-1355 84 62 . . NOUN dti-1355 84 63 8 8 NUM dti-1355 84 64 5 5 NUM dti-1355 84 65 . . NOUN dti-1355 84 66 0 0 NUM dti-1355 84 67 ± ± NUM dti-1355 84 68 1 1 NUM dti-1355 84 69 . . NOUN dti-1355 84 70 0 0 NUM dti-1355 84 71 5 5 NUM dti-1355 84 72 . . SYM dti-1355 84 73 0 0 NUM dti-1355 85 1 ± ± NUM dti-1355 85 2 0 0 NUM dti-1355 85 3 . . PUNCT dti-1355 86 1 9 9 NUM dti-1355 86 2 4 4 NUM dti-1355 86 3 . . NOUN dti-1355 86 4 9 9 NUM dti-1355 86 5 ± ± NUM dti-1355 86 6 0 0 NUM dti-1355 86 7 . . PUNCT dti-1355 86 8 7 7 NUM dti-1355 86 9 5 5 NUM dti-1355 86 10 . . NOUN dti-1355 86 11 0 0 NUM dti-1355 87 1 ± ± NUM dti-1355 87 2 0 0 NUM dti-1355 87 3 . . NOUN dti-1355 87 4 8 8 NUM dti-1355 87 5 5 5 NUM dti-1355 87 6 . . NOUN dti-1355 87 7 0 0 NUM dti-1355 88 1 ± ± NUM dti-1355 88 2 0 0 NUM dti-1355 88 3 . . PUNCT dti-1355 89 1 9 9 NUM dti-1355 89 2 0 0 NUM dti-1355 89 3 . . PUNCT dti-1355 90 1 99 99 NUM dti-1355 90 2 9 9 NUM dti-1355 90 3 c c NOUN dti-1355 90 4 l l NOUN dti-1355 90 5 ( ( PUNCT dti-1355 90 6 m m VERB dti-1355 90 7 m m VERB dti-1355 90 8 ol ol ADJ dti-1355 90 9 /l /l PUNCT dti-1355 90 10 ) ) PUNCT dti-1355 90 11 10 10 NUM dti-1355 90 12 2 2 NUM dti-1355 90 13 ± ± NUM dti-1355 90 14 5 5 NUM dti-1355 90 15 10 10 NUM dti-1355 90 16 3 3 NUM dti-1355 90 17 ± ± NUM dti-1355 90 18 4 4 NUM dti-1355 90 19 10 10 NUM dti-1355 90 20 3 3 NUM dti-1355 90 21 ± ± NUM dti-1355 90 22 4 4 NUM dti-1355 90 23 10 10 NUM dti-1355 90 24 3 3 NUM dti-1355 90 25 ± ± NUM dti-1355 90 26 4 4 NUM dti-1355 90 27 10 10 NUM dti-1355 90 28 3 3 NUM dti-1355 90 29 ± ± NUM dti-1355 90 30 5 5 NUM dti-1355 90 31 10 10 NUM dti-1355 90 32 2 2 NUM dti-1355 90 33 ± ± NUM dti-1355 90 34 4 4 NUM dti-1355 90 35 10 10 NUM dti-1355 90 36 3 3 NUM dti-1355 90 37 ± ± NUM dti-1355 90 38 3 3 NUM dti-1355 90 39 0 0 NUM dti-1355 90 40 . . PUNCT dti-1355 91 1 93 93 NUM dti-1355 91 2 c c NOUN dti-1355 91 3 a a PRON dti-1355 91 4 ( ( PUNCT dti-1355 91 5 m m NOUN dti-1355 91 6 g/ g/ NOUN dti-1355 91 7 dl dl PROPN dti-1355 91 8 ) ) PUNCT dti-1355 91 9 8 8 NUM dti-1355 91 10 . . NOUN dti-1355 91 11 8 8 NUM dti-1355 91 12 ± ± NUM dti-1355 91 13 0 0 NUM dti-1355 91 14 . . NOUN dti-1355 91 15 8 8 NUM dti-1355 91 16 9 9 NUM dti-1355 91 17 . . NOUN dti-1355 91 18 0 0 NUM dti-1355 91 19 ± ± NUM dti-1355 91 20 0 0 NUM dti-1355 91 21 . . PUNCT dti-1355 91 22 9 9 NUM dti-1355 91 23 8 8 NUM dti-1355 91 24 . . NOUN dti-1355 91 25 8 8 NUM dti-1355 91 26 ± ± NUM dti-1355 91 27 0 0 NUM dti-1355 91 28 . . PROPN dti-1355 91 29 6 6 NUM dti-1355 91 30 8 8 NUM dti-1355 91 31 . . NOUN dti-1355 91 32 8 8 NUM dti-1355 91 33 ± ± NUM dti-1355 91 34 0 0 NUM dti-1355 91 35 . . PROPN dti-1355 91 36 6 6 NUM dti-1355 91 37 8 8 NUM dti-1355 91 38 . . PUNCT dti-1355 91 39 9 9 NUM dti-1355 91 40 ± ± NUM dti-1355 91 41 0 0 NUM dti-1355 91 42 . . PUNCT dti-1355 91 43 7 7 NUM dti-1355 91 44 9 9 NUM dti-1355 91 45 . . NOUN dti-1355 91 46 1 1 NUM dti-1355 91 47 ± ± NUM dti-1355 91 48 0 0 NUM dti-1355 91 49 . . NOUN dti-1355 91 50 8 8 NUM dti-1355 91 51 9 9 NUM dti-1355 91 52 . . NOUN dti-1355 91 53 0 0 NUM dti-1355 91 54 ± ± NUM dti-1355 91 55 0 0 NUM dti-1355 91 56 . . PUNCT dti-1355 92 1 9 9 NUM dti-1355 92 2 0 0 NUM dti-1355 92 3 . . NOUN dti-1355 92 4 85 85 NUM dti-1355 92 5 2 2 NUM dti-1355 92 6 p p NOUN dti-1355 93 1 i i PRON dti-1355 93 2 ( ( PUNCT dti-1355 93 3 m m PROPN dti-1355 93 4 g/ g/ NOUN dti-1355 93 5 dl dl PROPN dti-1355 93 6 ) ) PUNCT dti-1355 93 7 4 4 NUM dti-1355 93 8 . . NOUN dti-1355 93 9 5 5 NUM dti-1355 93 10 ± ± NUM dti-1355 93 11 1 1 NUM dti-1355 93 12 . . NOUN dti-1355 93 13 3 3 NUM dti-1355 93 14 5 5 NUM dti-1355 93 15 . . NOUN dti-1355 93 16 1 1 NUM dti-1355 93 17 ± ± NUM dti-1355 93 18 1 1 NUM dti-1355 93 19 . . NOUN dti-1355 93 20 2 2 NUM dti-1355 93 21 5 5 NUM dti-1355 93 22 . . SYM dti-1355 93 23 3 3 NUM dti-1355 93 24 ± ± NUM dti-1355 93 25 1 1 NUM dti-1355 93 26 . . NOUN dti-1355 93 27 4 4 NUM dti-1355 93 28 5 5 NUM dti-1355 93 29 . . NOUN dti-1355 93 30 0 0 NUM dti-1355 93 31 ± ± NUM dti-1355 93 32 0 0 NUM dti-1355 93 33 . . PUNCT dti-1355 93 34 9 9 NUM dti-1355 93 35 5 5 NUM dti-1355 93 36 . . NOUN dti-1355 93 37 1 1 NUM dti-1355 93 38 ± ± NUM dti-1355 93 39 1 1 NUM dti-1355 93 40 . . NOUN dti-1355 93 41 5 5 NUM dti-1355 93 42 5 5 NUM dti-1355 93 43 . . NOUN dti-1355 93 44 6 6 NUM dti-1355 93 45 ± ± NUM dti-1355 93 46 1 1 NUM dti-1355 93 47 . . NOUN dti-1355 93 48 5 5 NUM dti-1355 93 49 4 4 NUM dti-1355 93 50 . . NOUN dti-1355 93 51 9 9 NUM dti-1355 93 52 ± ± NUM dti-1355 93 53 1 1 NUM dti-1355 93 54 . . NOUN dti-1355 93 55 0 0 NUM dti-1355 93 56 0 0 NUM dti-1355 93 57 . . NOUN dti-1355 93 58 29 29 NUM dti-1355 93 59 6 6 NUM dti-1355 93 60 a a DET dti-1355 93 61 s s X dti-1355 93 62 t t NOUN dti-1355 93 63 ( ( PUNCT dti-1355 93 64 u u PROPN dti-1355 93 65 /l /l PUNCT dti-1355 93 66 ) ) PUNCT dti-1355 93 67 16 16 NUM dti-1355 93 68 .5 .5 NUM dti-1355 93 69 ± ± NUM dti-1355 93 70 1 1 NUM dti-1355 93 71 5 5 NUM dti-1355 93 72 . . NOUN dti-1355 93 73 8 8 NUM dti-1355 93 74 18 18 NUM dti-1355 93 75 .0 .0 NUM dti-1355 93 76 ± ± NUM dti-1355 93 77 1 1 NUM dti-1355 93 78 5 5 NUM dti-1355 93 79 . . ADP dti-1355 93 80 4 4 NUM dti-1355 93 81 15 15 NUM dti-1355 93 82 .0 .0 NUM dti-1355 93 83 ± ± NUM dti-1355 93 84 6 6 NUM dti-1355 93 85 .7 .7 NUM dti-1355 93 86 15 15 NUM dti-1355 93 87 .0 .0 NUM dti-1355 93 88 ± ± NUM dti-1355 93 89 6 6 NUM dti-1355 93 90 .4 .4 NUM dti-1355 93 91 17 17 NUM dti-1355 93 92 .2 .2 NUM dti-1355 93 93 ± ± NUM dti-1355 93 94 7 7 NUM dti-1355 93 95 .5 .5 NUM dti-1355 93 96 18 18 NUM dti-1355 93 97 .4 .4 NUM dti-1355 93 98 ± ± NUM dti-1355 93 99 8 8 NUM dti-1355 93 100 .4 .4 NUM dti-1355 93 101 18 18 NUM dti-1355 93 102 .3 .3 NUM dti-1355 93 103 ± ± NUM dti-1355 93 104 1 1 NUM dti-1355 93 105 3 3 NUM dti-1355 93 106 . . NOUN dti-1355 93 107 6 6 NUM dti-1355 93 108 0 0 NUM dti-1355 93 109 . . PUNCT dti-1355 94 1 93 93 NUM dti-1355 94 2 8 8 NUM dti-1355 94 3 a a PRON dti-1355 94 4 lt lt PRON dti-1355 94 5 ( ( PUNCT dti-1355 94 6 u u PROPN dti-1355 94 7 /l /l PUNCT dti-1355 94 8 ) ) PUNCT dti-1355 94 9 17 17 NUM dti-1355 94 10 .9 .9 NUM dti-1355 94 11 ± ± NUM dti-1355 94 12 1 1 NUM dti-1355 94 13 7 7 NUM dti-1355 94 14 . . NOUN dti-1355 94 15 6 6 NUM dti-1355 94 16 18 18 NUM dti-1355 94 17 .8 .8 NUM dti-1355 94 18 ± ± NUM dti-1355 94 19 1 1 NUM dti-1355 94 20 6 6 NUM dti-1355 94 21 . . NOUN dti-1355 94 22 7 7 NUM dti-1355 94 23 15 15 NUM dti-1355 94 24 .2 .2 NUM dti-1355 94 25 ± ± NUM dti-1355 94 26 9 9 NUM dti-1355 94 27 .4 .4 NUM dti-1355 94 28 14 14 NUM dti-1355 94 29 .4 .4 NUM dti-1355 94 30 ± ± NUM dti-1355 94 31 8 8 NUM dti-1355 94 32 .3 .3 NUM dti-1355 94 33 14 14 NUM dti-1355 94 34 .0 .0 NUM dti-1355 94 35 ± ± NUM dti-1355 94 36 8 8 NUM dti-1355 94 37 .0 .0 NUM dti-1355 94 38 17 17 NUM dti-1355 94 39 .5 .5 NUM dti-1355 94 40 ± ± NUM dti-1355 94 41 1 1 NUM dti-1355 94 42 0 0 NUM dti-1355 94 43 . . NOUN dti-1355 94 44 4 4 NUM dti-1355 94 45 19 19 NUM dti-1355 94 46 .4 .4 NUM dti-1355 94 47 ± ± NUM dti-1355 94 48 1 1 NUM dti-1355 94 49 8 8 NUM dti-1355 94 50 . . ADP dti-1355 94 51 2 2 NUM dti-1355 94 52 0 0 NUM dti-1355 94 53 . . NOUN dti-1355 94 54 85 85 NUM dti-1355 94 55 7 7 NUM dti-1355 94 56 ld ld PROPN dti-1355 94 57 h h NOUN dti-1355 94 58 ( ( PUNCT dti-1355 94 59 u u PROPN dti-1355 94 60 /l /l PUNCT dti-1355 94 61 ) ) PUNCT dti-1355 94 62 17 17 NUM dti-1355 94 63 9 9 NUM dti-1355 94 64 ± ± NUM dti-1355 94 65 40 40 NUM dti-1355 94 66 18 18 NUM dti-1355 94 67 9 9 NUM dti-1355 94 68 ± ± NUM dti-1355 94 69 39 39 NUM dti-1355 94 70 17 17 NUM dti-1355 94 71 9 9 NUM dti-1355 94 72 ± ± NUM dti-1355 94 73 28 28 NUM dti-1355 94 74 17 17 NUM dti-1355 94 75 8 8 NUM dti-1355 94 76 ± ± NUM dti-1355 94 77 26 26 NUM dti-1355 94 78 18 18 NUM dti-1355 94 79 0 0 NUM dti-1355 94 80 ± ± NUM dti-1355 94 81 30 30 NUM dti-1355 94 82 19 19 NUM dti-1355 94 83 1 1 NUM dti-1355 94 84 ± ± NUM dti-1355 94 85 45 45 NUM dti-1355 94 86 18 18 NUM dti-1355 94 87 8 8 NUM dti-1355 94 88 ± ± NUM dti-1355 94 89 48 48 NUM dti-1355 94 90 0 0 NUM dti-1355 94 91 . . PUNCT dti-1355 95 1 92 92 NUM dti-1355 95 2 3 3 NUM dti-1355 95 3 n n NUM dti-1355 95 4 ot ot NOUN dti-1355 95 5 e e NOUN dti-1355 95 6 : : PUNCT dti-1355 95 7 * * PUNCT dti-1355 95 8 p p NOUN dti-1355 95 9   PROPN dti-1355 95 10 0 0 NUM dti-1355 95 11 .0 .0 NUM dti-1355 95 12 5 5 NUM dti-1355 95 13 ve ve NOUN dti-1355 95 14 rs r VERB dti-1355 95 15 us we PRON dti-1355 95 16 b b PROPN dti-1355 95 17 as as ADP dti-1355 95 18 el el PROPN dti-1355 95 19 in in ADP dti-1355 95 20 e. e. PROPN dti-1355 95 21 http://www.la-press.com http://www.la-press.com X dti-1355 96 1 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1355 97 1 akimoto akimoto PROPN dti-1355 97 2 et et PROPN dti-1355 97 3 al al PROPN dti-1355 97 4 42 42 NUM dti-1355 97 5 drug drug NOUN dti-1355 97 6 target target NOUN dti-1355 97 7 insights insight VERB dti-1355 97 8 2014:8 2014:8 NUM dti-1355 97 9 table table NOUN dti-1355 97 10 3 3 NUM dti-1355 97 11 . . PUNCT dti-1355 98 1 the the DET dti-1355 98 2 serum serum NOUN dti-1355 98 3 levels level NOUN dti-1355 98 4 of of ADP dti-1355 98 5 several several ADJ dti-1355 98 6 oxidative oxidative ADJ dti-1355 98 7 stress stress NOUN dti-1355 98 8 markers marker NOUN dti-1355 98 9 before before ADV dti-1355 98 10 and and CCONJ dti-1355 98 11 after after ADP dti-1355 98 12 the the DET dti-1355 98 13 initiation initiation NOUN dti-1355 98 14 of of ADP dti-1355 98 15 the the DET dti-1355 98 16 treatment treatment NOUN dti-1355 98 17 with with ADP dti-1355 98 18 oral oral ADJ dti-1355 98 19 febuxostat febuxostat NOUN dti-1355 98 20 . . PUNCT dti-1355 99 1 after after ADP dti-1355 99 2 the the DET dti-1355 99 3 initiation initiation NOUN dti-1355 99 4 of of ADP dti-1355 99 5 oral oral ADJ dti-1355 99 6 febuxostat febuxostat NOUN dti-1355 99 7 treatment treatment NOUN dti-1355 99 8 p p NOUN dti-1355 99 9 value value NOUN dti-1355 99 10 baseline baseline NOUN dti-1355 99 11 1 1 NUM dti-1355 99 12 month month NOUN dti-1355 99 13 3 3 NUM dti-1355 99 14 months month NOUN dti-1355 99 15 6 6 NUM dti-1355 99 16 months month NOUN dti-1355 99 17 protein protein NOUN dti-1355 99 18 carbonyls carbonyls NOUN dti-1355 99 19 ( ( PUNCT dti-1355 99 20 nmol nmol NOUN dti-1355 99 21 / / SYM dti-1355 99 22 mg mg PROPN dti-1355 99 23 protein protein NOUN dti-1355 99 24 ) ) PUNCT dti-1355 99 25 0.07 0.07 NUM dti-1355 99 26 ( ( PUNCT dti-1355 99 27 ir ir NOUN dti-1355 99 28 : : NOUN dti-1355 99 29 0.03–0.12 0.03–0.12 NOUN dti-1355 99 30 ) ) PUNCT dti-1355 99 31 0.10 0.10 NUM dti-1355 99 32 ( ( PUNCT dti-1355 99 33 ir ir NOUN dti-1355 99 34 : : PUNCT dti-1355 99 35 0.06–0.14 0.06–0.14 NOUN dti-1355 99 36 ) ) PUNCT dti-1355 100 1 0.07 0.07 NUM dti-1355 100 2 ( ( PUNCT dti-1355 100 3 ir ir NOUN dti-1355 100 4 : : PUNCT dti-1355 100 5 0.06–0.15 0.06–0.15 NUM dti-1355 100 6 ) ) PUNCT dti-1355 100 7 0.05 0.05 NUM dti-1355 100 8 ( ( PUNCT dti-1355 100 9 ir ir NOUN dti-1355 100 10 : : PUNCT dti-1355 100 11 0.03–0.11 0.03–0.11 NUM dti-1355 100 12 ) ) PUNCT dti-1355 100 13 0.329 0.329 NUM dti-1355 100 14 3 3 NUM dti-1355 100 15 - - PUNCT dti-1355 100 16 nt not PART dti-1355 100 17 ( ( PUNCT dti-1355 100 18 nm nm NOUN dti-1355 100 19 ) ) PUNCT dti-1355 100 20 30.4 30.4 NUM dti-1355 100 21 ( ( PUNCT dti-1355 100 22 ir ir NOUN dti-1355 100 23 : : PUNCT dti-1355 100 24 25.2–40.4 25.2–40.4 NUM dti-1355 100 25 ) ) PUNCT dti-1355 100 26 33.2 33.2 NUM dti-1355 100 27 ( ( PUNCT dti-1355 100 28 ir ir PROPN dti-1355 100 29 : : PUNCT dti-1355 100 30 25.5–42.2 25.5–42.2 NUM dti-1355 100 31 ) ) PUNCT dti-1355 100 32 37.3 37.3 NUM dti-1355 100 33 ( ( PUNCT dti-1355 100 34 ir ir PROPN dti-1355 100 35 : : PUNCT dti-1355 100 36 25.3–45.3 25.3–45.3 NUM dti-1355 100 37 ) ) PUNCT dti-1355 100 38 28.7 28.7 NUM dti-1355 100 39 ( ( PUNCT dti-1355 100 40 ir ir NOUN dti-1355 100 41 : : PUNCT dti-1355 100 42 24.7–43.9 24.7–43.9 NUM dti-1355 100 43 ) ) PUNCT dti-1355 100 44 0.928 0.928 NUM dti-1355 100 45 8 8 NUM dti-1355 100 46 - - PUNCT dti-1355 100 47 ohdg ohdg NOUN dti-1355 100 48 ( ( PUNCT dti-1355 100 49 ng ng PROPN dti-1355 100 50 / / SYM dti-1355 100 51 ml ml PROPN dti-1355 100 52 ) ) PUNCT dti-1355 100 53 1.64 1.64 NUM dti-1355 100 54 ( ( PUNCT dti-1355 100 55 ir ir NOUN dti-1355 100 56 : : PUNCT dti-1355 100 57 1.24–2.95 1.24–2.95 NUM dti-1355 100 58 ) ) PUNCT dti-1355 100 59 2.51 2.51 NUM dti-1355 100 60 ( ( PUNCT dti-1355 100 61 ir ir NOUN dti-1355 100 62 : : PUNCT dti-1355 100 63 1.24–4.74 1.24–4.74 NUM dti-1355 100 64 ) ) PUNCT dti-1355 100 65 1.05 1.05 NUM dti-1355 100 66 ( ( PUNCT dti-1355 100 67 ir ir NOUN dti-1355 100 68 : : PUNCT dti-1355 100 69 0.84–1.87 0.84–1.87 NUM dti-1355 100 70 ) ) PUNCT dti-1355 100 71 0.54 0.54 NUM dti-1355 100 72 ( ( PUNCT dti-1355 100 73 ir ir NOUN dti-1355 100 74 : : PUNCT dti-1355 100 75 0.204–1.16 0.204–1.16 NOUN dti-1355 100 76 ) ) PUNCT dti-1355 100 77 * * PUNCT dti-1355 100 78 0.002 0.002 NUM dti-1355 100 79 note note NOUN dti-1355 100 80 : : PUNCT dti-1355 100 81 * * PUNCT dti-1355 100 82 p p NOUN dti-1355 100 83   PROPN dti-1355 100 84 0.05 0.05 NUM dti-1355 100 85 versus versus ADP dti-1355 100 86 baseline baseline NOUN dti-1355 100 87 . . PUNCT dti-1355 101 1 hyperuricemia hyperuricemia NOUN dti-1355 101 2 remains remain VERB dti-1355 101 3 to to PART dti-1355 101 4 be be AUX dti-1355 101 5 delineated delineate VERB dti-1355 101 6 , , PUNCT dti-1355 101 7 and and CCONJ dti-1355 101 8 clinicians clinician NOUN dti-1355 101 9 should should AUX dti-1355 101 10 bear bear VERB dti-1355 101 11 in in ADP dti-1355 101 12 mind mind NOUN dti-1355 101 13 that that SCONJ dti-1355 101 14 the the DET dti-1355 101 15 prevalence prevalence NOUN dti-1355 101 16 of of ADP dti-1355 101 17 refractory refractory NOUN dti-1355 101 18 gout gout NOUN dti-1355 101 19 and/or and/or CCONJ dti-1355 101 20 gouty gouty ADJ dti-1355 101 21 tophi tophi NOUN dti-1355 101 22 is be AUX dti-1355 101 23 much much ADV dti-1355 101 24 lower low ADJ dti-1355 101 25 in in ADP dti-1355 101 26 japan japan PROPN dti-1355 101 27 in in ADP dti-1355 101 28 comparison comparison NOUN dti-1355 101 29 to to ADP dti-1355 101 30 that that PRON dti-1355 101 31 in in ADP dti-1355 101 32 the the DET dti-1355 101 33 united united PROPN dti-1355 101 34 states states PROPN dti-1355 101 35 and and CCONJ dti-1355 101 36 europe europe PROPN dti-1355 101 37 , , PUNCT dti-1355 101 38 where where SCONJ dti-1355 101 39 negative negative ADJ dti-1355 101 40 opinions opinion NOUN dti-1355 101 41 regarding regard VERB dti-1355 101 42 pharmaceutical pharmaceutical ADJ dti-1355 101 43 interventions intervention NOUN dti-1355 101 44 predominate.11–14 predominate.11–14 VERB dti-1355 101 45     SPACE dti-1355 101 46 one one PRON dti-1355 101 47 may may AUX dti-1355 101 48 argue argue VERB dti-1355 101 49 that that SCONJ dti-1355 101 50 the the DET dti-1355 101 51 clinical clinical ADJ dti-1355 101 52 benefit benefit NOUN dti-1355 101 53 of of ADP dti-1355 101 54 using use VERB dti-1355 101 55 urate urate NOUN dti-1355 101 56 - - PUNCT dti-1355 101 57 lowering lower VERB dti-1355 101 58 agents agent NOUN dti-1355 101 59 requires require VERB dti-1355 101 60 careful careful ADJ dti-1355 101 61 evaluation evaluation NOUN dti-1355 101 62 , , PUNCT dti-1355 101 63 especially especially ADV dti-1355 101 64 in in ADP dti-1355 101 65 subjects subject NOUN dti-1355 101 66 on on ADP dti-1355 101 67 chronic chronic ADJ dti-1355 101 68 hd hd NOUN dti-1355 101 69 treatment treatment NOUN dti-1355 101 70 , , PUNCT dti-1355 101 71 since since SCONJ dti-1355 101 72 an an DET dti-1355 101 73 incipient incipient ADJ dti-1355 101 74 gouty gouty ADJ dti-1355 101 75 attack attack NOUN dti-1355 101 76 is be AUX dti-1355 101 77 quite quite ADV dti-1355 101 78 rare rare ADJ dti-1355 101 79 in in ADP dti-1355 101 80 hyperuricemic hyperuricemic ADJ dti-1355 101 81 long long ADJ dti-1355 101 82 - - PUNCT dti-1355 101 83 term term NOUN dti-1355 101 84 hd hd NOUN dti-1355 101 85 patients patient NOUN dti-1355 101 86 , , PUNCT dti-1355 101 87 and and CCONJ dti-1355 101 88 the the DET dti-1355 101 89 frequency frequency NOUN dti-1355 101 90 of of ADP dti-1355 101 91 gouty gouty ADJ dti-1355 101 92 arthritis arthritis NOUN dti-1355 101 93 has have AUX dti-1355 101 94 been be AUX dti-1355 101 95 shown show VERB dti-1355 101 96 to to PART dti-1355 101 97 decrease decrease VERB dti-1355 101 98 after after ADP dti-1355 101 99 the the DET dti-1355 101 100 initiation initiation NOUN dti-1355 101 101 of of ADP dti-1355 101 102 a a DET dti-1355 101 103 periodic periodic ADJ dti-1355 101 104 hd hd NOUN dti-1355 101 105 program program NOUN dti-1355 101 106 in in ADP dti-1355 101 107 advanced advanced ADJ dti-1355 101 108 ckd ckd PROPN dti-1355 101 109 subjects.15,16 subjects.15,16 NOUN dti-1355 101 110     SPACE dti-1355 101 111 moreover moreover ADV dti-1355 101 112 , , PUNCT dti-1355 101 113 a a DET dti-1355 101 114 significant significant ADJ dti-1355 101 115 association association NOUN dti-1355 101 116 between between ADP dti-1355 101 117 higher high ADJ dti-1355 101 118 serum serum PROPN dti-1355 101 119 ua ua PROPN dti-1355 101 120 levels level NOUN dti-1355 101 121 and and CCONJ dti-1355 101 122 lower low ADJ dti-1355 101 123 mortality mortality NOUN dti-1355 101 124 , , PUNCT dti-1355 101 125 which which PRON dti-1355 101 126 may may AUX dti-1355 101 127 be be AUX dti-1355 101 128 dependent dependent ADJ dti-1355 101 129 on on ADP dti-1355 101 130 the the DET dti-1355 101 131 favorable favorable ADJ dti-1355 101 132 nutritional nutritional ADJ dti-1355 101 133 status status NOUN dti-1355 101 134 , , PUNCT dti-1355 101 135 has have AUX dti-1355 101 136 been be AUX dti-1355 101 137 demonstrated demonstrate VERB dti-1355 101 138 in in ADP dti-1355 101 139 the the DET dti-1355 101 140 hd hd PROPN dti-1355 101 141 population.17 population.17 PROPN dti-1355 101 142     SPACE dti-1355 101 143 otherwise otherwise ADV dti-1355 101 144 , , PUNCT dti-1355 101 145 it it PRON dti-1355 101 146 may may AUX dti-1355 101 147 be be AUX dti-1355 101 148 necessary necessary ADJ dti-1355 101 149 to to PART dti-1355 101 150 focus focus VERB dti-1355 101 151 on on ADP dti-1355 101 152 the the DET dti-1355 101 153 fact fact NOUN dti-1355 101 154 that that SCONJ dti-1355 101 155 some some PRON dti-1355 101 156 of of ADP dti-1355 101 157 the the DET dti-1355 101 158 reactive reactive ADJ dti-1355 101 159 oxygen oxygen NOUN dti-1355 101 160 species specie NOUN dti-1355 101 161 are be AUX dti-1355 101 162 produced produce VERB dti-1355 101 163 as as ADP dti-1355 101 164 a a DET dti-1355 101 165 by by ADP dti-1355 101 166 - - PUNCT dti-1355 101 167 product product NOUN dti-1355 101 168 of of ADP dti-1355 101 169 urate urate NOUN dti-1355 101 170 formation formation NOUN dti-1355 101 171 through through ADP dti-1355 101 172 a a DET dti-1355 101 173 xodependent xodependent ADJ dti-1355 101 174 pathway pathway NOUN dti-1355 101 175 and and CCONJ dti-1355 101 176 the the DET dti-1355 101 177 pharmacological pharmacological ADJ dti-1355 101 178 nature nature NOUN dti-1355 101 179 of of ADP dti-1355 101 180 febuxostat febuxostat NOUN dti-1355 101 181 , , PUNCT dti-1355 101 182 which which PRON dti-1355 101 183 is be AUX dti-1355 101 184 characterized characterize VERB dti-1355 101 185 by by ADP dti-1355 101 186 a a DET dti-1355 101 187 higher high ADJ dti-1355 101 188 bioavailability bioavailability NOUN dti-1355 101 189 and and CCONJ dti-1355 101 190 a a DET dti-1355 101 191 more more ADV dti-1355 101 192 potent potent ADJ dti-1355 101 193 blockade blockade NOUN dti-1355 101 194 of of ADP dti-1355 101 195 xo xo PROPN dti-1355 101 196 activity activity NOUN dti-1355 101 197 than than ADP dti-1355 101 198 the the DET dti-1355 101 199 traditional traditional ADJ dti-1355 101 200 xo xo PROPN dti-1355 101 201 inhibitor inhibitor PROPN dti-1355 101 202 allopurinol.1,2,8,18 allopurinol.1,2,8,18 PROPN dti-1355 101 203     SPACE dti-1355 101 204 indeed indeed ADV dti-1355 101 205 , , PUNCT dti-1355 101 206 the the DET dti-1355 101 207 superior superior ADJ dti-1355 101 208 potency potency NOUN dti-1355 101 209 of of ADP dti-1355 101 210 febuxostat febuxostat NOUN dti-1355 101 211 to to PART dti-1355 101 212 allopurinol allopurinol VERB dti-1355 101 213 for for ADP dti-1355 101 214 the the DET dti-1355 101 215 inhibition inhibition NOUN dti-1355 101 216 of of ADP dti-1355 101 217 reactive reactive ADJ dti-1355 101 218 oxygen oxygen NOUN dti-1355 101 219 synthesis synthesis NOUN dti-1355 101 220 has have AUX dti-1355 101 221 been be AUX dti-1355 101 222 demonstrated demonstrate VERB dti-1355 101 223 in in ADP dti-1355 101 224 several several ADJ dti-1355 101 225 reports,19,20 reports,19,20 NOUN dti-1355 101 226     SPACE dti-1355 101 227 and and CCONJ dti-1355 101 228 the the DET dti-1355 101 229 serum serum PROPN dti-1355 101 230 ua ua PROPN dti-1355 101 231 levels level NOUN dti-1355 101 232 could could AUX dti-1355 101 233 be be AUX dti-1355 101 234 used use VERB dti-1355 101 235 as as ADP dti-1355 101 236 a a DET dti-1355 101 237 surrogate surrogate ADJ dti-1355 101 238 indicator indicator NOUN dti-1355 101 239 of of ADP dti-1355 101 240 the the DET dti-1355 101 241 xo xo PROPN dti-1355 101 242 activity activity NOUN dti-1355 101 243 . . PUNCT dti-1355 102 1 in in ADP dti-1355 102 2 the the DET dti-1355 102 3 current current ADJ dti-1355 102 4 study study NOUN dti-1355 102 5 , , PUNCT dti-1355 102 6 8 8 NUM dti-1355 102 7 - - SYM dti-1355 102 8 ohdg ohdg VERB dti-1355 102 9 , , PUNCT dti-1355 102 10 3 3 NUM dti-1355 102 11 - - PUNCT dti-1355 102 12 nt not PART dti-1355 102 13 , , PUNCT dti-1355 102 14 and and CCONJ dti-1355 102 15 protein protein NOUN dti-1355 102 16 carbonyls carbonyls NOUN dti-1355 102 17 , , PUNCT dti-1355 102 18 which which PRON dti-1355 102 19 have have AUX dti-1355 102 20 been be AUX dti-1355 102 21 included include VERB dti-1355 102 22 in in ADP dti-1355 102 23 the the DET dti-1355 102 24 list list NOUN dti-1355 102 25 of of ADP dti-1355 102 26 the the DET dti-1355 102 27 most most ADV dti-1355 102 28 common common ADJ dti-1355 102 29 oxidative oxidative ADJ dti-1355 102 30 stress stress NOUN dti-1355 102 31 biomarkers biomarker NOUN dti-1355 102 32 in in ADP dti-1355 102 33 various various ADJ dti-1355 102 34 settings,20,21 settings,20,21 NOUN dti-1355 102 35     SPACE dti-1355 102 36 were be AUX dti-1355 102 37 used use VERB dti-1355 102 38 as as ADP dti-1355 102 39 the the DET dti-1355 102 40 indices index NOUN dti-1355 102 41 of of ADP dti-1355 102 42 the the DET dti-1355 102 43 condition condition NOUN dti-1355 102 44 of of ADP dti-1355 102 45 the the DET dti-1355 102 46 present present ADJ dti-1355 102 47 patients patient NOUN dti-1355 102 48 . . PUNCT dti-1355 103 1 numerous numerous ADJ dti-1355 103 2 processes process NOUN dti-1355 103 3 other other ADJ dti-1355 103 4 than than ADP dti-1355 103 5 the the DET dti-1355 103 6 xo xo PROPN dti-1355 103 7 - - PUNCT dti-1355 103 8 mediated mediate VERB dti-1355 103 9 pathway pathway NOUN dti-1355 103 10 have have AUX dti-1355 103 11 been be AUX dti-1355 103 12 implicated implicate VERB dti-1355 103 13 in in ADP dti-1355 103 14 the the DET dti-1355 103 15 oxidative oxidative ADJ dti-1355 103 16 stress stress NOUN dti-1355 103 17 among among ADP dti-1355 103 18 the the DET dti-1355 103 19 subjects subject NOUN dti-1355 103 20 with with ADP dti-1355 103 21 ckd.21,22 ckd.21,22 NOUN dti-1355 103 22     SPACE dti-1355 103 23 in in ADP dti-1355 103 24 addition addition NOUN dti-1355 103 25 , , PUNCT dti-1355 103 26 it it PRON dti-1355 103 27 has have AUX dti-1355 103 28 been be AUX dti-1355 103 29 shown show VERB dti-1355 103 30 that that SCONJ dti-1355 103 31 chronic chronic ADJ dti-1355 103 32 hd hd NOUN dti-1355 103 33 treatment treatment NOUN dti-1355 103 34 also also ADV dti-1355 103 35 leads lead VERB dti-1355 103 36 to to ADP dti-1355 103 37 excessive excessive ADJ dti-1355 103 38 radical radical ADJ dti-1355 103 39 production production NOUN dti-1355 103 40 and and CCONJ dti-1355 103 41 impairment impairment NOUN dti-1355 103 42 of of ADP dti-1355 103 43 the the DET dti-1355 103 44 anti anti ADJ dti-1355 103 45 - - ADJ dti-1355 103 46 oxidant oxidant ADJ dti-1355 103 47 capacity.23 capacity.23 NOUN dti-1355 103 48     SPACE dti-1355 103 49 despite despite SCONJ dti-1355 103 50 the the DET dti-1355 103 51 lack lack NOUN dti-1355 103 52 of of ADP dti-1355 103 53 qualitative qualitative ADJ dti-1355 103 54 information information NOUN dti-1355 103 55 regarding regard VERB dti-1355 103 56 the the DET dti-1355 103 57 significance significance NOUN dti-1355 103 58 of of ADP dti-1355 103 59 individual individual ADJ dti-1355 103 60 oxidative oxidative ADJ dti-1355 103 61 stress stress NOUN dti-1355 103 62 markers,24 markers,24 NOUN dti-1355 103 63     SPACE dti-1355 103 64 we we PRON dti-1355 103 65 feel feel VERB dti-1355 103 66 that that SCONJ dti-1355 103 67 it it PRON dti-1355 103 68 is be AUX dti-1355 103 69 reasonable reasonable ADJ dti-1355 103 70 to to PART dti-1355 103 71 consider consider VERB dti-1355 103 72 that that SCONJ dti-1355 103 73 8 8 NUM dti-1355 103 74 - - SYM dti-1355 103 75 ohdg ohdg VERB dti-1355 103 76 , , PUNCT dti-1355 103 77 but but CCONJ dti-1355 103 78 not not PART dti-1355 103 79 3 3 NUM dti-1355 103 80 - - PUNCT dti-1355 103 81 nt not PART dti-1355 103 82 and and CCONJ dti-1355 103 83 protein protein NOUN dti-1355 103 84 carbonyls carbonyls NOUN dti-1355 103 85 , , PUNCT dti-1355 103 86 may may AUX dti-1355 103 87 help help VERB dti-1355 103 88 to to PART dti-1355 103 89 detect detect VERB dti-1355 103 90 the the DET dti-1355 103 91 inhibitory inhibitory ADJ dti-1355 103 92 effects effect NOUN dti-1355 103 93 of of ADP dti-1355 103 94 febuxostat febuxostat NOUN dti-1355 103 95 on on ADP dti-1355 103 96 xo xo PROPN dti-1355 103 97 - - PUNCT dti-1355 103 98 mediated mediate VERB dti-1355 103 99 oxidative oxidative ADJ dti-1355 103 100 stress stress NOUN dti-1355 103 101 among among ADP dti-1355 103 102 the the DET dti-1355 103 103 chronic chronic ADJ dti-1355 103 104 hd hd NOUN dti-1355 103 105 patients patient NOUN dti-1355 103 106 . . PUNCT dti-1355 104 1 although although SCONJ dti-1355 104 2 the the DET dti-1355 104 3 precise precise ADJ dti-1355 104 4 role role NOUN dti-1355 104 5 of of ADP dti-1355 104 6 febuxostat febuxostat NOUN dti-1355 104 7 in in ADP dti-1355 104 8 reducing reduce VERB dti-1355 104 9 the the DET dti-1355 104 10 serum serum NOUN dti-1355 104 11 levels level NOUN dti-1355 104 12 of of ADP dti-1355 104 13 8 8 NUM dti-1355 104 14 - - PUNCT dti-1355 104 15 ohdg ohdg NOUN dti-1355 104 16 remains remain VERB dti-1355 104 17 to to PART dti-1355 104 18 be be AUX dti-1355 104 19 delineated delineate VERB dti-1355 104 20 , , PUNCT dti-1355 104 21 our our PRON dti-1355 104 22 findings finding NOUN dti-1355 104 23 suggest suggest VERB dti-1355 104 24 that that SCONJ dti-1355 104 25 the the DET dti-1355 104 26 generation generation NOUN dti-1355 104 27 of of ADP dti-1355 104 28 8 8 NUM dti-1355 104 29 - - PUNCT dti-1355 104 30 ohdg ohdg NOUN dti-1355 104 31 may may AUX dti-1355 104 32 be be AUX dti-1355 104 33 more more ADV dti-1355 104 34 dependent dependent ADJ dti-1355 104 35 on on ADP dti-1355 104 36 xo xo PROPN dti-1355 104 37 than than ADP dti-1355 104 38 that that PRON dti-1355 104 39 of of ADP dti-1355 104 40 3 3 NUM dti-1355 104 41 - - PUNCT dti-1355 104 42 nt not PART dti-1355 104 43 or or CCONJ dti-1355 104 44 protein protein NOUN dti-1355 104 45 carbonyls carbonyl VERB dti-1355 104 46 . . PUNCT dti-1355 105 1 on on ADP dti-1355 105 2 the the DET dti-1355 105 3 other other ADJ dti-1355 105 4 hand hand NOUN dti-1355 105 5 , , PUNCT dti-1355 105 6 it it PRON dti-1355 105 7 has have AUX dti-1355 105 8 been be AUX dti-1355 105 9 proposed propose VERB dti-1355 105 10 that that SCONJ dti-1355 105 11 the the DET dti-1355 105 12 xo xo PROPN dti-1355 105 13 inhibitors inhibitor NOUN dti-1355 105 14 may may AUX dti-1355 105 15 be be AUX dti-1355 105 16 utilized utilize VERB dti-1355 105 17 as as ADP dti-1355 105 18 adjunctive adjunctive ADJ dti-1355 105 19 anti anti ADJ dti-1355 105 20 - - ADJ dti-1355 105 21 hypertensive hypertensive ADJ dti-1355 105 22 agents agent NOUN dti-1355 105 23 in in ADP dti-1355 105 24 some some DET dti-1355 105 25 subsets subset NOUN dti-1355 105 26 of of ADP dti-1355 105 27 hyperuricemic hyperuricemic ADJ dti-1355 105 28 and and CCONJ dti-1355 105 29 hypertensive hypertensive ADJ dti-1355 105 30 subjects subject NOUN dti-1355 105 31 associated associate VERB dti-1355 105 32 with with ADP dti-1355 105 33 or or CCONJ dti-1355 105 34 without without ADP dti-1355 105 35 advanced advanced ADJ dti-1355 105 36 ckd,25,26 ckd,25,26 PROPN dti-1355 105 37     SPACE dti-1355 105 38 while while SCONJ dti-1355 105 39 we we PRON dti-1355 105 40 found find VERB dti-1355 105 41 that that SCONJ dti-1355 105 42 the the DET dti-1355 105 43 systolic systolic ADJ dti-1355 105 44 bp bp PROPN dti-1355 105 45 levels level NOUN dti-1355 105 46 after after ADP dti-1355 105 47 five five NUM dti-1355 105 48 and and CCONJ dti-1355 105 49 six six NUM dti-1355 105 50 months month NOUN dti-1355 105 51 of of ADP dti-1355 105 52 treatment treatment NOUN dti-1355 105 53 with with ADP dti-1355 105 54 febuxostat febuxostat NOUN dti-1355 105 55 were be AUX dti-1355 105 56 higher high ADJ dti-1355 105 57 than than ADP dti-1355 105 58 those those PRON dti-1355 105 59 at at ADP dti-1355 105 60 baseline baseline NOUN dti-1355 105 61 , , PUNCT dti-1355 105 62 despite despite SCONJ dti-1355 105 63 the the DET dti-1355 105 64 titration titration NOUN dti-1355 105 65 of of ADP dti-1355 105 66 anti anti ADJ dti-1355 105 67 - - ADJ dti-1355 105 68 hypertensive hypertensive ADJ dti-1355 105 69 agents agent NOUN dti-1355 105 70 corresponding correspond VERB dti-1355 105 71 to to ADP dti-1355 105 72 the the DET dti-1355 105 73 context context NOUN dti-1355 105 74 . . PUNCT dti-1355 106 1 we we PRON dti-1355 106 2 have have VERB dti-1355 106 3 no no DET dti-1355 106 4 explanation explanation NOUN dti-1355 106 5 for for ADP dti-1355 106 6 this this DET dti-1355 106 7 discrepancy discrepancy NOUN dti-1355 106 8 ; ; PUNCT dti-1355 106 9 however however ADV dti-1355 106 10 , , PUNCT dti-1355 106 11 a a DET dti-1355 106 12 seasonal seasonal ADJ dti-1355 106 13 bias bias NOUN dti-1355 106 14 may may AUX dti-1355 106 15 have have AUX dti-1355 106 16 been be AUX dti-1355 106 17 involved involve VERB dti-1355 106 18 . . PUNCT dti-1355 107 1 indeed indeed ADV dti-1355 107 2 , , PUNCT dti-1355 107 3 it it PRON dti-1355 107 4 has have AUX dti-1355 107 5 been be AUX dti-1355 107 6 reported report VERB dti-1355 107 7 that that SCONJ dti-1355 107 8 the the DET dti-1355 107 9 systolic systolic ADJ dti-1355 107 10 bp bp PROPN dti-1355 107 11 shows show VERB dti-1355 107 12 seasonal seasonal ADJ dti-1355 107 13 changes change NOUN dti-1355 107 14 in in ADP dti-1355 107 15 chronic chronic ADJ dti-1355 107 16 hd hd NOUN dti-1355 107 17 patients patient NOUN dti-1355 107 18 , , PUNCT dti-1355 107 19 with with SCONJ dti-1355 107 20 peak peak NOUN dti-1355 107 21 bp bp PROPN dti-1355 107 22 noted note VERB dti-1355 107 23 in in ADP dti-1355 107 24 the the DET dti-1355 107 25 winter.27 winter.27 PROPN dti-1355 107 26 finally finally ADV dti-1355 107 27 , , PUNCT dti-1355 107 28 the the DET dti-1355 107 29 number number NOUN dti-1355 107 30 of of ADP dti-1355 107 31 patients patient NOUN dti-1355 107 32 included include VERB dti-1355 107 33 in in ADP dti-1355 107 34 the the DET dti-1355 107 35 present present ADJ dti-1355 107 36 series series NOUN dti-1355 107 37 was be AUX dti-1355 107 38 quite quite ADV dti-1355 107 39 small small ADJ dti-1355 107 40 , , PUNCT dti-1355 107 41 thus thus ADV dti-1355 107 42 implying imply VERB dti-1355 107 43 that that SCONJ dti-1355 107 44 this this DET dti-1355 107 45 study study NOUN dti-1355 107 46 may may AUX dti-1355 107 47 be be AUX dti-1355 107 48 statistically statistically ADV dti-1355 107 49 underpowered underpowered ADJ dti-1355 107 50 or or CCONJ dti-1355 107 51 that that SCONJ dti-1355 107 52 the the DET dti-1355 107 53 clinical clinical ADJ dti-1355 107 54 parameters parameter NOUN dti-1355 107 55 may may AUX dti-1355 107 56 have have AUX dti-1355 107 57 been be AUX dti-1355 107 58 overestimated overestimate VERB dti-1355 107 59 . . PUNCT dti-1355 108 1 as as ADP dti-1355 108 2 such such ADJ dti-1355 108 3 , , PUNCT dti-1355 108 4 our our PRON dti-1355 108 5 findings finding NOUN dti-1355 108 6 should should AUX dti-1355 108 7 be be AUX dti-1355 108 8 interpreted interpret VERB dti-1355 108 9 with with ADP dti-1355 108 10 caution caution NOUN dti-1355 108 11 . . PUNCT dti-1355 109 1 nevertheless nevertheless ADV dti-1355 109 2 , , PUNCT dti-1355 109 3 our our PRON dti-1355 109 4 results result NOUN dti-1355 109 5 encourage encourage VERB dti-1355 109 6 us we PRON dti-1355 109 7 to to PART dti-1355 109 8 pursue pursue VERB dti-1355 109 9 further further ADJ dti-1355 109 10 investigations investigation NOUN dti-1355 109 11 regarding regard VERB dti-1355 109 12 the the DET dti-1355 109 13 clinical clinical ADJ dti-1355 109 14 impact impact NOUN dti-1355 109 15 of of ADP dti-1355 109 16 lowering lower VERB dti-1355 109 17 the the DET dti-1355 109 18 serum serum NOUN dti-1355 109 19 ua ua PROPN dti-1355 109 20 level level VERB dti-1355 109 21 with with ADP dti-1355 109 22 febuxostat febuxostat NOUN dti-1355 109 23 in in ADP dti-1355 109 24 chronic chronic ADJ dti-1355 109 25 hd hd NOUN dti-1355 109 26 patients patient NOUN dti-1355 109 27 in in ADP dti-1355 109 28 terms term NOUN dti-1355 109 29 of of ADP dti-1355 109 30 determining determine VERB dti-1355 109 31 the the DET dti-1355 109 32 appropriate appropriate ADJ dti-1355 109 33 dose dose NOUN dti-1355 109 34 of of ADP dti-1355 109 35 the the DET dti-1355 109 36 agent agent NOUN dti-1355 109 37 as as ADV dti-1355 109 38 well well ADV dti-1355 109 39 as as ADP dti-1355 109 40 concomitantly concomitantly ADV dti-1355 109 41 reducing reduce VERB dti-1355 109 42 oxidative oxidative ADJ dti-1355 109 43 stress stress NOUN dti-1355 109 44 by by ADP dti-1355 109 45 blocking block VERB dti-1355 109 46 xo xo PROPN dti-1355 109 47 . . PUNCT dti-1355 110 1 indeed indeed ADV dti-1355 110 2 , , PUNCT dti-1355 110 3 despite despite SCONJ dti-1355 110 4 the the DET dti-1355 110 5 comparable comparable ADJ dti-1355 110 6 serum serum NOUN dti-1355 110 7 levels level NOUN dti-1355 110 8 of of ADP dti-1355 110 9 low low ADJ dti-1355 110 10 - - PUNCT dti-1355 110 11 density density NOUN dti-1355 110 12 lipoprotein lipoprotein ADJ dti-1355 110 13 ( ( PUNCT dti-1355 110 14 ldl ldl NOUN dti-1355 110 15 ) ) PUNCT dti-1355 110 16 between between ADP dti-1355 110 17 baseline baseline NOUN dti-1355 110 18 and and CCONJ dti-1355 110 19 week week NOUN dti-1355 110 20 24 24 NUM dti-1355 110 21 , , PUNCT dti-1355 110 22 we we PRON dti-1355 110 23 found find VERB dti-1355 110 24 that that SCONJ dti-1355 110 25 the the DET dti-1355 110 26 serum serum NOUN dti-1355 110 27 levels level NOUN dti-1355 110 28 of of ADP dti-1355 110 29 the the DET dti-1355 110 30 oxidative oxidative ADJ dti-1355 110 31 form form NOUN dti-1355 110 32 of of ADP dti-1355 110 33 ldl ldl NOUN dti-1355 110 34 , , PUNCT dti-1355 110 35 another another DET dti-1355 110 36 oxidative oxidative ADJ dti-1355 110 37 stress stress NOUN dti-1355 110 38 marker,20 marker,20 ADP dti-1355 110 39     SPACE dti-1355 110 40 at at ADP dti-1355 110 41 week week NOUN dti-1355 110 42 24 24 NUM dti-1355 110 43     SPACE dti-1355 110 44 were be AUX dti-1355 110 45 significantly significantly ADV dti-1355 110 46 decreased decrease VERB dti-1355 110 47 compared compare VERB dti-1355 110 48 to to ADP dti-1355 110 49 those those PRON dti-1355 110 50 observed observe VERB dti-1355 110 51 at at ADP dti-1355 110 52 baseline baseline NOUN dti-1355 110 53 among among ADP dti-1355 110 54 the the DET dti-1355 110 55 12 12 NUM dti-1355 110 56     SPACE dti-1355 110 57 subjects subject NOUN dti-1355 110 58 who who PRON dti-1355 110 59 led lead VERB dti-1355 110 60 us we PRON dti-1355 110 61 to to PART dti-1355 110 62 determine determine VERB dti-1355 110 63 the the DET dti-1355 110 64 serum serum NOUN dti-1355 110 65 levels level NOUN dti-1355 110 66 of of ADP dti-1355 110 67 these these DET dti-1355 110 68 parameters parameter NOUN dti-1355 110 69 ( ( PUNCT dti-1355 110 70 data datum NOUN dti-1355 110 71 not not PART dti-1355 110 72 shown show VERB dti-1355 110 73 ) ) PUNCT dti-1355 110 74 . . PUNCT dti-1355 111 1 obviously obviously ADV dti-1355 111 2 , , PUNCT dti-1355 111 3 more more ADV dti-1355 111 4 detailed detailed ADJ dti-1355 111 5 studies study NOUN dti-1355 111 6 with with ADP dti-1355 111 7 a a DET dti-1355 111 8 larger large ADJ dti-1355 111 9 number number NOUN dti-1355 111 10 of of ADP dti-1355 111 11 subjects subject NOUN dti-1355 111 12 and and CCONJ dti-1355 111 13 assessments assessment NOUN dti-1355 111 14 of of ADP dti-1355 111 15 the the DET dti-1355 111 16 effects effect NOUN dti-1355 111 17 of of ADP dti-1355 111 18 multiple multiple ADJ dti-1355 111 19 factors factor NOUN dti-1355 111 20 affecting affect VERB dti-1355 111 21 hyperuricemia hyperuricemia ADV dti-1355 111 22 , , PUNCT dti-1355 111 23 such such ADJ dti-1355 111 24 as as ADP dti-1355 111 25 age age NOUN dti-1355 111 26 , , PUNCT dti-1355 111 27 sex sex NOUN dti-1355 111 28 , , PUNCT dti-1355 111 29 and and CCONJ dti-1355 111 30 dietary dietary ADJ dti-1355 111 31 habits,2,14 habits,2,14 PRON dti-1355 111 32     SPACE dti-1355 111 33 would would AUX dti-1355 111 34 shed shed VERB dti-1355 111 35 light light NOUN dti-1355 111 36 on on ADP dti-1355 111 37 the the DET dti-1355 111 38 therapeutic therapeutic ADJ dti-1355 111 39 challenges challenge NOUN dti-1355 111 40 of of ADP dti-1355 111 41 treating treat VERB dti-1355 111 42 asymptomatic asymptomatic ADJ dti-1355 111 43 hyperuricemia hyperuricemia NOUN dti-1355 111 44 in in ADP dti-1355 111 45 patients patient NOUN dti-1355 111 46 with with ADP dti-1355 111 47 various various ADJ dti-1355 111 48 stages stage NOUN dti-1355 111 49 of of ADP dti-1355 111 50 ckd.28 ckd.28 NOUN dti-1355 111 51 author author NOUN dti-1355 111 52 contributions contribution NOUN dti-1355 111 53 ta ta PART dti-1355 111 54 drafted draft VERB dti-1355 111 55 the the DET dti-1355 111 56 manuscript manuscript NOUN dti-1355 111 57 . . PUNCT dti-1355 112 1 ym ym PROPN dti-1355 112 2 , , PUNCT dti-1355 112 3 ci ci PROPN dti-1355 112 4 , , PUNCT dti-1355 112 5 oi oi PROPN dti-1355 112 6 , , PUNCT dti-1355 112 7 st st PROPN dti-1355 112 8 , , PUNCT dti-1355 112 9 and and CCONJ dti-1355 112 10 yw yw PROPN dti-1355 112 11 made make VERB dti-1355 112 12 contributions contribution NOUN dti-1355 112 13 to to ADP dti-1355 112 14 the the DET dti-1355 112 15 acquisition acquisition NOUN dti-1355 112 16 of of ADP dti-1355 112 17 the the DET dti-1355 112 18 clinical clinical ADJ dti-1355 112 19 data datum NOUN dti-1355 112 20 . . PUNCT dti-1355 113 1 ek ek PROPN dti-1355 113 2 and and CCONJ dti-1355 113 3 dn dn PROPN dti-1355 113 4 provided provide VERB dti-1355 113 5 a a DET dti-1355 113 6 detailed detailed ADJ dti-1355 113 7 review review NOUN dti-1355 113 8 of of ADP dti-1355 113 9 the the DET dti-1355 113 10 contents content NOUN dti-1355 113 11 and and CCONJ dti-1355 113 12 structure structure NOUN dti-1355 113 13 of of ADP dti-1355 113 14 the the DET dti-1355 113 15 manuscript manuscript NOUN dti-1355 113 16 , , PUNCT dti-1355 113 17 resulting result VERB dti-1355 113 18 in in ADP dti-1355 113 19 significant significant ADJ dti-1355 113 20 changes change NOUN dti-1355 113 21 to to ADP dti-1355 113 22 the the DET dti-1355 113 23 original original ADJ dti-1355 113 24 document document NOUN dti-1355 113 25 . . PUNCT dti-1355 114 1 all all DET dti-1355 114 2 authors author NOUN dti-1355 114 3 have have AUX dti-1355 114 4 read read VERB dti-1355 114 5 and and CCONJ dti-1355 114 6 approved approve VERB dti-1355 114 7 the the DET dti-1355 114 8 final final ADJ dti-1355 114 9 manuscript manuscript NOUN dti-1355 114 10 . . PUNCT dti-1355 115 1 http://www.la-press.com http://www.la-press.com X dti-1355 115 2 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 NOUN dti-1355 115 3 febuxostat febuxostat NOUN dti-1355 115 4 and and CCONJ dti-1355 115 5 advanced advanced ADJ dti-1355 115 6 chronic chronic ADJ dti-1355 115 7 kidney kidney NOUN dti-1355 115 8 disease disease NOUN dti-1355 115 9 patients patient NOUN dti-1355 115 10 43drug 43drug PRON dti-1355 116 1 target target NOUN dti-1355 116 2 insights insight VERB dti-1355 116 3 2014:8 2014:8 NUM dti-1355 116 4 references reference NOUN dti-1355 116 5 1 1 NUM dti-1355 116 6 . . PUNCT dti-1355 116 7 gaffo gaffo PROPN dti-1355 116 8 al al PROPN dti-1355 116 9 , , PUNCT dti-1355 116 10 saag saag PROPN dti-1355 116 11 kg kg PROPN dti-1355 116 12 . . PUNCT dti-1355 116 13 febuxostat febuxostat PROPN dti-1355 116 14 : : PUNCT dti-1355 116 15 the the DET dti-1355 116 16 evidence evidence NOUN dti-1355 116 17 for for ADP dti-1355 116 18 its its PRON dti-1355 116 19 use use NOUN dti-1355 116 20 in in ADP dti-1355 116 21 the the DET dti-1355 116 22 treatment treatment NOUN dti-1355 116 23 of of ADP dti-1355 116 24 hyperuricemia hyperuricemia NOUN dti-1355 116 25 and and CCONJ dti-1355 116 26 gout gout NOUN dti-1355 116 27 . . PUNCT dti-1355 117 1 core core PROPN dti-1355 117 2 evid evid PROPN dti-1355 117 3 . . PUNCT dti-1355 118 1 2009;4:25–36 2009;4:25–36 NUM dti-1355 118 2 . . NOUN dti-1355 118 3 2 2 NUM dti-1355 118 4 . . X dti-1355 118 5 becker becker PROPN dti-1355 118 6 ma ma PROPN dti-1355 118 7 , , PUNCT dti-1355 118 8 schumacher schumacher PROPN dti-1355 118 9 hr hr PROPN dti-1355 118 10 jr jr PROPN dti-1355 118 11 , , PUNCT dti-1355 118 12 wortmann wortmann PROPN dti-1355 118 13 rl rl PROPN dti-1355 118 14 , , PUNCT dti-1355 118 15 et et PROPN dti-1355 118 16     SPACE dti-1355 118 17 al al PROPN dti-1355 118 18 . . PROPN dti-1355 118 19 febuxostat febuxostat NOUN dti-1355 118 20 compared compare VERB dti-1355 118 21 with with ADP dti-1355 118 22 allopurinol allopurinol NOUN dti-1355 118 23 in in ADP dti-1355 118 24 patients patient NOUN dti-1355 118 25 with with ADP dti-1355 118 26 hyperuricemia hyperuricemia NOUN dti-1355 118 27 and and CCONJ dti-1355 118 28 gout gout NOUN dti-1355 118 29 . . PUNCT dti-1355 119 1 n n PROPN dti-1355 119 2 engl engl PROPN dti-1355 119 3 j j PROPN dti-1355 119 4 med med PROPN dti-1355 119 5 . . PUNCT dti-1355 119 6 2005 2005 NUM dti-1355 119 7 ; ; PUNCT dti-1355 119 8 353(23):2450–2461 353(23):2450–2461 NUM dti-1355 119 9 . . X dti-1355 120 1 3 3 X dti-1355 120 2 . . X dti-1355 120 3 whelton whelton PROPN dti-1355 120 4 a a PROPN dti-1355 120 5 , , PUNCT dti-1355 120 6 macdonald macdonald PROPN dti-1355 120 7 pa pa PROPN dti-1355 120 8 , , PUNCT dti-1355 120 9 zhao zhao PROPN dti-1355 120 10 l l PROPN dti-1355 120 11 , , PUNCT dti-1355 120 12 hunt hunt PROPN dti-1355 120 13 b b NUM dti-1355 120 14 , , PUNCT dti-1355 120 15 gunawardhana gunawardhana PROPN dti-1355 120 16 l. l. PROPN dti-1355 120 17 renal renal PROPN dti-1355 120 18 function function NOUN dti-1355 120 19 in in ADP dti-1355 120 20 gout gout NOUN dti-1355 120 21 : : PUNCT dti-1355 120 22 long long ADJ dti-1355 120 23 - - PUNCT dti-1355 120 24 term term NOUN dti-1355 120 25 treatment treatment NOUN dti-1355 120 26 effects effect NOUN dti-1355 120 27 of of ADP dti-1355 120 28 febuxostat febuxostat NOUN dti-1355 120 29 . . PUNCT dti-1355 121 1 j j PROPN dti-1355 121 2 clin clin PROPN dti-1355 121 3 rheumatol rheumatol NOUN dti-1355 121 4 . . PUNCT dti-1355 122 1 2011;17(1):7–13 2011;17(1):7–13 X dti-1355 122 2 . . NOUN dti-1355 122 3 4 4 X dti-1355 122 4 . . X dti-1355 122 5 fujimori fujimori PROPN dti-1355 122 6 s s PROPN dti-1355 122 7 , , PUNCT dti-1355 122 8 ooyama ooyama PROPN dti-1355 122 9 k k NOUN dti-1355 122 10 , , PUNCT dti-1355 122 11 ooyama ooyama NOUN dti-1355 122 12 h h NOUN dti-1355 122 13 , , PUNCT dti-1355 122 14 moromizato moromizato PROPN dti-1355 122 15 h. h. PROPN dti-1355 122 16 efficacy efficacy PROPN dti-1355 122 17 of of ADP dti-1355 122 18 benzbromarone benzbromarone NOUN dti-1355 122 19 in in ADP dti-1355 122 20 hyperuricemic hyperuricemic ADJ dti-1355 122 21 patients patient NOUN dti-1355 122 22 associated associate VERB dti-1355 122 23 with with ADP dti-1355 122 24 chronic chronic ADJ dti-1355 122 25 kidney kidney NOUN dti-1355 122 26 disease disease NOUN dti-1355 122 27 . . PUNCT dti-1355 122 28 nucleosides nucleoside VERB dti-1355 122 29 nucleotides nucleotide NOUN dti-1355 122 30 nucleic nucleic ADJ dti-1355 122 31 acids acid NOUN dti-1355 122 32 . . PUNCT dti-1355 123 1 2011;30(12):1035–1038 2011;30(12):1035–1038 NUM dti-1355 123 2 . . PROPN dti-1355 124 1 5 5 NUM dti-1355 124 2 . . X dti-1355 124 3 dalbeth dalbeth PROPN dti-1355 124 4 n n CCONJ dti-1355 124 5 , , PUNCT dti-1355 124 6 kumar kumar PROPN dti-1355 124 7 s s PROPN dti-1355 124 8 , , PUNCT dti-1355 124 9 stamp stamp NOUN dti-1355 124 10 l l NOUN dti-1355 124 11 , , PUNCT dti-1355 124 12 gow gow NOUN dti-1355 124 13 p. p. PROPN dti-1355 124 14 dose dose NOUN dti-1355 124 15 adjustment adjustment NOUN dti-1355 124 16 of of ADP dti-1355 124 17 allopurinol allopurinol NOUN dti-1355 124 18 according accord VERB dti-1355 124 19 to to ADP dti-1355 124 20 creatinine creatinine NOUN dti-1355 124 21 clearance clearance NOUN dti-1355 124 22 does do AUX dti-1355 124 23 not not PART dti-1355 124 24 provide provide VERB dti-1355 124 25 adequate adequate ADJ dti-1355 124 26 control control NOUN dti-1355 124 27 of of ADP dti-1355 124 28 hyperuricemia hyperuricemia NOUN dti-1355 124 29 in in ADP dti-1355 124 30 patients patient NOUN dti-1355 124 31 with with ADP dti-1355 124 32 gout gout NOUN dti-1355 124 33 . . PUNCT dti-1355 125 1 j j PROPN dti-1355 125 2 rheumatol rheumatol NOUN dti-1355 125 3 . . PUNCT dti-1355 126 1 2006;33(8):1646–1650 2006;33(8):1646–1650 NOUN dti-1355 126 2 . . PUNCT dti-1355 127 1 6 6 NUM dti-1355 127 2 . . X dti-1355 127 3 hosoya hosoya PROPN dti-1355 127 4 t t PROPN dti-1355 127 5 , , PUNCT dti-1355 127 6 ono ono PROPN dti-1355 127 7 i. i. PROPN dti-1355 127 8 a a DET dti-1355 127 9 repeated repeat VERB dti-1355 127 10 oral oral ADJ dti-1355 127 11 administration administration NOUN dti-1355 127 12 study study NOUN dti-1355 127 13 of of ADP dti-1355 127 14 febuxostat febuxostat NOUN dti-1355 127 15 ( ( PUNCT dti-1355 127 16 tmx-67 tmx-67 NUM dti-1355 127 17 ) ) PUNCT dti-1355 127 18 , , PUNCT dti-1355 127 19 a a DET dti-1355 127 20 non non ADJ dti-1355 127 21 - - ADJ dti-1355 127 22 purine purine ADJ dti-1355 127 23 - - PUNCT dti-1355 127 24 selective selective ADJ dti-1355 127 25 inhibitor inhibitor NOUN dti-1355 127 26 of of ADP dti-1355 127 27 xanthine xanthine NOUN dti-1355 127 28 oxidase oxidase NOUN dti-1355 127 29 , , PUNCT dti-1355 127 30 in in ADP dti-1355 127 31 patients patient NOUN dti-1355 127 32 with with ADP dti-1355 127 33 impaired impaired ADJ dti-1355 127 34 renal renal ADJ dti-1355 127 35 function function NOUN dti-1355 127 36 in in ADP dti-1355 127 37 japan japan PROPN dti-1355 127 38 : : PUNCT dti-1355 127 39 pharmacokinetic pharmacokinetic ADJ dti-1355 127 40 and and CCONJ dti-1355 127 41 pharmacodynamic pharmacodynamic ADJ dti-1355 127 42 study study NOUN dti-1355 127 43 . . PUNCT dti-1355 128 1 j j PROPN dti-1355 128 2 clin clin PROPN dti-1355 128 3 rheumatol rheumatol NOUN dti-1355 128 4 . . PUNCT dti-1355 129 1 2011;17(4 2011;17(4 NUM dti-1355 129 2     SPACE dti-1355 129 3 suppl suppl ADJ dti-1355 129 4 2):s27 2):s27 NUM dti-1355 129 5 – – PUNCT dti-1355 129 6 s34 s34 NOUN dti-1355 129 7 . . PUNCT dti-1355 130 1 7 7 X dti-1355 130 2 . . X dti-1355 130 3 horikoshi horikoshi PROPN dti-1355 130 4 r r PROPN dti-1355 130 5 , , PUNCT dti-1355 130 6 akimoto akimoto PROPN dti-1355 130 7 t t PROPN dti-1355 130 8 , , PUNCT dti-1355 130 9 inoue inoue PROPN dti-1355 130 10 m m PROPN dti-1355 130 11 , , PUNCT dti-1355 130 12 morishita morishita PROPN dti-1355 130 13 y y PROPN dti-1355 130 14 , , PUNCT dti-1355 130 15 kusano kusano PROPN dti-1355 130 16 e. e. NOUN dti-1355 130 17 febuxostat febuxostat NOUN dti-1355 130 18 for for ADP dti-1355 130 19 hyperuricemia hyperuricemia NOUN dti-1355 130 20 : : PUNCT dti-1355 130 21 experience experience NOUN dti-1355 130 22 with with ADP dti-1355 130 23 patients patient NOUN dti-1355 130 24 on on ADP dti-1355 130 25 chronic chronic ADJ dti-1355 130 26 hemodialysis hemodialysis NOUN dti-1355 130 27 treatment treatment NOUN dti-1355 130 28 . . PUNCT dti-1355 131 1 clin clin PROPN dti-1355 131 2 exp exp NOUN dti-1355 131 3 nephrol nephrol PROPN dti-1355 131 4 . . PUNCT dti-1355 132 1 2013;17(1):149–150 2013;17(1):149–150 NUM dti-1355 132 2 . . NOUN dti-1355 132 3 8 8 NUM dti-1355 132 4 . . PUNCT dti-1355 133 1 george george PROPN dti-1355 133 2 j j PROPN dti-1355 133 3 , , PUNCT dti-1355 133 4 carr carr PROPN dti-1355 133 5 e e PROPN dti-1355 133 6 , , PUNCT dti-1355 133 7 davies davies PROPN dti-1355 133 8 j j PROPN dti-1355 133 9 , , PUNCT dti-1355 133 10 belch belch PROPN dti-1355 133 11 jj jj PROPN dti-1355 133 12 , , PUNCT dti-1355 133 13 struthers struthers PROPN dti-1355 133 14 a. a. PROPN dti-1355 133 15 high high ADV dti-1355 133 16 - - PUNCT dti-1355 133 17 dose dose NOUN dti-1355 133 18 allopurinol allopurinol NOUN dti-1355 133 19 improves improve VERB dti-1355 133 20 endothelial endothelial ADJ dti-1355 133 21 function function NOUN dti-1355 133 22 by by ADP dti-1355 133 23 profoundly profoundly ADV dti-1355 133 24 reducing reduce VERB dti-1355 133 25 vascular vascular ADJ dti-1355 133 26 oxidative oxidative ADJ dti-1355 133 27 stress stress NOUN dti-1355 133 28 and and CCONJ dti-1355 133 29 not not PART dti-1355 133 30 by by ADP dti-1355 133 31 lowering lower VERB dti-1355 133 32 uric uric ADJ dti-1355 133 33 acid acid NOUN dti-1355 133 34 . . PUNCT dti-1355 133 35 circulation circulation NOUN dti-1355 133 36 . . PUNCT dti-1355 134 1 2006;114(23):2508–2516 2006;114(23):2508–2516 NUM dti-1355 134 2 . . X dti-1355 135 1 9 9 NUM dti-1355 135 2 . . X dti-1355 135 3 tsuda tsuda NOUN dti-1355 135 4 h h PROPN dti-1355 135 5 , , PUNCT dti-1355 135 6 kawada kawada PROPN dti-1355 135 7 n n CCONJ dti-1355 135 8 , , PUNCT dti-1355 135 9 kaimori kaimori PROPN dti-1355 135 10 jy jy PROPN dti-1355 135 11 , , PUNCT dti-1355 135 12 et et PROPN dti-1355 135 13     SPACE dti-1355 135 14 al al PROPN dti-1355 135 15 . . PROPN dti-1355 135 16 febuxostat febuxostat PROPN dti-1355 135 17 suppressed suppress VERB dti-1355 135 18 renal renal ADJ dti-1355 135 19 ischemiareperfusion ischemiareperfusion NOUN dti-1355 135 20 injury injury NOUN dti-1355 135 21 via via ADP dti-1355 135 22 reduced reduce VERB dti-1355 135 23 oxidative oxidative ADJ dti-1355 135 24 stress stress NOUN dti-1355 135 25 . . PUNCT dti-1355 136 1 biochem biochem PROPN dti-1355 136 2 biophys biophy VERB dti-1355 136 3 res re NOUN dti-1355 136 4 commun commun PROPN dti-1355 136 5 . . PUNCT dti-1355 137 1 2012;427(2):266–272 2012;427(2):266–272 NUM dti-1355 137 2 . . PROPN dti-1355 137 3 10 10 NUM dti-1355 137 4 . . PUNCT dti-1355 137 5 morishita morishita PROPN dti-1355 137 6 y y PROPN dti-1355 137 7 , , PUNCT dti-1355 137 8 watanabe watanabe PROPN dti-1355 137 9 m m PROPN dti-1355 137 10 , , PUNCT dti-1355 137 11 hirahara hirahara VERB dti-1355 137 12 i i PROPN dti-1355 137 13 , , PUNCT dti-1355 137 14 akimoto akimoto PROPN dti-1355 137 15 t t PROPN dti-1355 137 16 , , PUNCT dti-1355 137 17 muto muto PROPN dti-1355 137 18 s s PART dti-1355 137 19 , , PUNCT dti-1355 137 20 kusano kusano PROPN dti-1355 137 21 e. e. PROPN dti-1355 137 22 level level PROPN dti-1355 137 23 of of ADP dti-1355 137 24 8 8 NUM dti-1355 137 25 - - PUNCT dti-1355 137 26 ohdg ohdg NOUN dti-1355 137 27 in in ADP dti-1355 137 28 drained drain VERB dti-1355 137 29 dialysate dialysate NOUN dti-1355 137 30 appears appear VERB dti-1355 137 31 to to PART dti-1355 137 32 be be AUX dti-1355 137 33 a a DET dti-1355 137 34 marker marker NOUN dti-1355 137 35 of of ADP dti-1355 137 36 peritoneal peritoneal ADJ dti-1355 137 37 damage damage NOUN dti-1355 137 38 in in ADP dti-1355 137 39 peritoneal peritoneal ADJ dti-1355 137 40 dialysis dialysis NOUN dti-1355 137 41 . . PUNCT dti-1355 138 1 int int PROPN dti-1355 139 1 j j PROPN dti-1355 139 2 nephrol nephrol PROPN dti-1355 139 3 renovasc renovasc PROPN dti-1355 139 4 dis dis PROPN dti-1355 139 5 . . PUNCT dti-1355 140 1 2012;5:9–14 2012;5:9–14 X dti-1355 140 2 . . NOUN dti-1355 140 3 11 11 NUM dti-1355 140 4 . . PUNCT dti-1355 141 1 yamanaka yamanaka PROPN dti-1355 141 2 h. h. PROPN dti-1355 141 3 japanese japanese ADJ dti-1355 141 4 society society NOUN dti-1355 141 5 of of ADP dti-1355 141 6 gout gout NOUN dti-1355 141 7 and and CCONJ dti-1355 141 8 nucleic nucleic ADJ dti-1355 141 9 acid acid NOUN dti-1355 141 10 metabolism metabolism NOUN dti-1355 141 11 . . PUNCT dti-1355 142 1 japanese japanese ADJ dti-1355 142 2 guideline guideline NOUN dti-1355 142 3 for for ADP dti-1355 142 4 the the DET dti-1355 142 5 management management NOUN dti-1355 142 6 of of ADP dti-1355 142 7 hyperuricemia hyperuricemia NOUN dti-1355 142 8 and and CCONJ dti-1355 142 9 gout gout NOUN dti-1355 142 10 : : PUNCT dti-1355 142 11 second second ADJ dti-1355 142 12 edition edition NOUN dti-1355 142 13 . . PUNCT dti-1355 142 14 nucleosides nucleoside VERB dti-1355 142 15 nucleotides nucleotide NOUN dti-1355 142 16 nucleic nucleic ADJ dti-1355 142 17 acids acid NOUN dti-1355 142 18 . . PUNCT dti-1355 143 1 2011;30(12):1018–1029 2011;30(12):1018–1029 NUM dti-1355 143 2 . . NOUN dti-1355 144 1 12 12 NUM dti-1355 144 2 . . PUNCT dti-1355 145 1 el el NOUN dti-1355 145 2 - - PUNCT dti-1355 145 3 zawawy zawawy PROPN dti-1355 145 4 h h PROPN dti-1355 145 5 , , PUNCT dti-1355 145 6 mandell mandell PROPN dti-1355 145 7 bf bf PROPN dti-1355 145 8 . . PUNCT dti-1355 146 1 managing manage VERB dti-1355 146 2 gout gout NOUN dti-1355 146 3 : : PUNCT dti-1355 146 4 how how SCONJ dti-1355 146 5 is be AUX dti-1355 146 6 it it PRON dti-1355 146 7 different different ADJ dti-1355 146 8 in in ADP dti-1355 146 9 patients patient NOUN dti-1355 146 10 with with ADP dti-1355 146 11 chronic chronic ADJ dti-1355 146 12 kidney kidney NOUN dti-1355 146 13 disease disease NOUN dti-1355 146 14 ? ? PUNCT dti-1355 147 1 cleve cleve PROPN dti-1355 147 2 clin clin PROPN dti-1355 147 3 j j PROPN dti-1355 147 4 med med PROPN dti-1355 147 5 . . PUNCT dti-1355 148 1 2010;77(12):919–928 2010;77(12):919–928 NUM dti-1355 148 2 . . PUNCT dti-1355 149 1 13 13 NUM dti-1355 149 2 . . PUNCT dti-1355 150 1 zhang zhang PROPN dti-1355 150 2 w w PROPN dti-1355 150 3 , , PUNCT dti-1355 150 4 doherty doherty PROPN dti-1355 150 5 m m PROPN dti-1355 150 6 , , PUNCT dti-1355 150 7 bardin bardin PROPN dti-1355 150 8 t t PROPN dti-1355 150 9 , , PUNCT dti-1355 150 10 et et PROPN dti-1355 150 11     SPACE dti-1355 150 12 al al PROPN dti-1355 150 13 . . PROPN dti-1355 150 14 eular eular ADJ dti-1355 150 15 evidence evidence NOUN dti-1355 150 16 based base VERB dti-1355 150 17 recommendations recommendation NOUN dti-1355 150 18 for for ADP dti-1355 150 19 gout gout NOUN dti-1355 150 20 . . PUNCT dti-1355 151 1 part part NOUN dti-1355 151 2 ii ii PROPN dti-1355 151 3 : : PUNCT dti-1355 151 4 management management NOUN dti-1355 151 5 . . PUNCT dti-1355 152 1 report report NOUN dti-1355 152 2 of of ADP dti-1355 152 3 a a DET dti-1355 152 4 task task NOUN dti-1355 152 5 force force NOUN dti-1355 152 6 of of ADP dti-1355 152 7 the the DET dti-1355 152 8 eular eular ADJ dti-1355 152 9 standing standing PROPN dti-1355 152 10 committee committee PROPN dti-1355 152 11 for for ADP dti-1355 152 12 international international ADJ dti-1355 152 13 clinical clinical ADJ dti-1355 152 14 studies study NOUN dti-1355 152 15 including include VERB dti-1355 152 16 therapeutics therapeutic NOUN dti-1355 152 17 ( ( PUNCT dti-1355 152 18 escisit escisit NOUN dti-1355 152 19 ) ) PUNCT dti-1355 152 20 . . PUNCT dti-1355 153 1 ann ann PROPN dti-1355 153 2 rheum rheum PROPN dti-1355 153 3 dis dis PROPN dti-1355 153 4 . . PUNCT dti-1355 154 1 2006;65:1312–1324 2006;65:1312–1324 NUM dti-1355 154 2 . . PUNCT dti-1355 155 1 14 14 NUM dti-1355 155 2 . . PUNCT dti-1355 156 1 smith smith PROPN dti-1355 156 2 eu eu PROPN dti-1355 156 3 , , PUNCT dti-1355 156 4 díaz díaz NOUN dti-1355 156 5 - - PUNCT dti-1355 156 6 torné torné NOUN dti-1355 156 7 c c NOUN dti-1355 156 8 , , PUNCT dti-1355 156 9 perez perez PROPN dti-1355 156 10 - - PUNCT dti-1355 156 11 ruiz ruiz NOUN dti-1355 156 12 f f PROPN dti-1355 156 13 , , PUNCT dti-1355 156 14 march march PROPN dti-1355 156 15 lm lm PROPN dti-1355 156 16 . . PUNCT dti-1355 157 1 epidemiology epidemiology NOUN dti-1355 157 2 of of ADP dti-1355 157 3 gout gout NOUN dti-1355 157 4 : : PUNCT dti-1355 157 5 an an DET dti-1355 157 6 update update NOUN dti-1355 157 7 . . PUNCT dti-1355 158 1 best good ADJ dti-1355 158 2 pract pract PROPN dti-1355 158 3 res re NOUN dti-1355 158 4 clin clin PROPN dti-1355 158 5 rheumatol rheumatol NOUN dti-1355 158 6 . . PUNCT dti-1355 159 1 2010;24(6):811–827 2010;24(6):811–827 X dti-1355 159 2 . . PUNCT dti-1355 160 1 15 15 NUM dti-1355 160 2 . . PUNCT dti-1355 161 1 ifudu ifudu PROPN dti-1355 161 2 o o PROPN dti-1355 161 3 , , PUNCT dti-1355 161 4 tan tan PROPN dti-1355 161 5 cc cc PROPN dti-1355 161 6 , , PUNCT dti-1355 161 7 dulin dulin PROPN dti-1355 161 8 al al PROPN dti-1355 161 9 , , PUNCT dti-1355 161 10 delano delano PROPN dti-1355 161 11 bg bg PROPN dti-1355 161 12 , , PUNCT dti-1355 161 13 friedman friedman PROPN dti-1355 161 14 ea ea PROPN dti-1355 161 15 . . PUNCT dti-1355 161 16 gouty gouty ADJ dti-1355 161 17 arthritis arthritis NOUN dti-1355 161 18 in in ADP dti-1355 161 19 end end NOUN dti-1355 161 20 - - PUNCT dti-1355 161 21 stage stage NOUN dti-1355 161 22 renal renal ADJ dti-1355 161 23 disease disease NOUN dti-1355 161 24 : : PUNCT dti-1355 161 25 clinical clinical ADJ dti-1355 161 26 course course NOUN dti-1355 161 27 and and CCONJ dti-1355 161 28 rarity rarity NOUN dti-1355 161 29 of of ADP dti-1355 161 30 new new ADJ dti-1355 161 31 cases case NOUN dti-1355 161 32 . . PUNCT dti-1355 161 33 am be AUX dti-1355 161 34 j j PROPN dti-1355 161 35 kidney kidney PROPN dti-1355 161 36 dis dis PROPN dti-1355 161 37 . . PUNCT dti-1355 162 1 1994;23(3):347–351 1994;23(3):347–351 X dti-1355 162 2 . . PUNCT dti-1355 163 1 16 16 NUM dti-1355 163 2 . . PUNCT dti-1355 164 1 ohno ohno PROPN dti-1355 164 2 i i PROPN dti-1355 164 3 , , PUNCT dti-1355 164 4 ichida ichida PROPN dti-1355 164 5 k k PROPN dti-1355 164 6 , , PUNCT dti-1355 164 7 okabe okabe PROPN dti-1355 164 8 h h PROPN dti-1355 164 9 , , PUNCT dti-1355 164 10 et et PROPN dti-1355 164 11     SPACE dti-1355 164 12 al al PROPN dti-1355 164 13 . . PROPN dti-1355 164 14 frequency frequency PROPN dti-1355 164 15 of of ADP dti-1355 164 16 gouty gouty ADJ dti-1355 164 17 arthritis arthritis NOUN dti-1355 164 18 in in ADP dti-1355 164 19 patients patient NOUN dti-1355 164 20 with with ADP dti-1355 164 21 end end NOUN dti-1355 164 22 - - PUNCT dti-1355 164 23 stage stage NOUN dti-1355 164 24 renal renal ADJ dti-1355 164 25 disease disease NOUN dti-1355 164 26 in in ADP dti-1355 164 27 japan japan PROPN dti-1355 164 28 . . PUNCT dti-1355 165 1 intern intern PROPN dti-1355 165 2 med med PROPN dti-1355 165 3 . . PUNCT dti-1355 166 1 2005;44(7):706–709 2005;44(7):706–709 NUM dti-1355 166 2 . . PROPN dti-1355 166 3 17 17 NUM dti-1355 166 4 . . PUNCT dti-1355 167 1 latif latif PROPN dti-1355 167 2 w w PROPN dti-1355 167 3 , , PUNCT dti-1355 167 4 karaboyas karaboyas PROPN dti-1355 167 5 a a PRON dti-1355 167 6 , , PUNCT dti-1355 167 7 tong tong PROPN dti-1355 167 8 l l PROPN dti-1355 167 9 , , PUNCT dti-1355 167 10 et et PROPN dti-1355 167 11     SPACE dti-1355 167 12 al al PROPN dti-1355 167 13 . . PROPN dti-1355 167 14 uric uric ADJ dti-1355 167 15 acid acid NOUN dti-1355 167 16 levels level NOUN dti-1355 167 17 and and CCONJ dti-1355 167 18 all all DET dti-1355 167 19 - - PUNCT dti-1355 167 20 cause cause NOUN dti-1355 167 21 and and CCONJ dti-1355 167 22 cardiovascular cardiovascular ADJ dti-1355 167 23 mortality mortality NOUN dti-1355 167 24 in in ADP dti-1355 167 25 the the DET dti-1355 167 26 hemodialysis hemodialysis NOUN dti-1355 167 27 population population NOUN dti-1355 167 28 . . PUNCT dti-1355 168 1 clin clin PROPN dti-1355 168 2 j j PROPN dti-1355 168 3 am be AUX dti-1355 168 4 soc soc NOUN dti-1355 168 5 nephrol nephrol NOUN dti-1355 168 6 . . PUNCT dti-1355 169 1 2011;6(10):2470–2477 2011;6(10):2470–2477 NOUN dti-1355 169 2 . . PUNCT dti-1355 170 1 18 18 NUM dti-1355 170 2 . . PUNCT dti-1355 171 1 george george PROPN dti-1355 171 2 j j PROPN dti-1355 171 3 , , PUNCT dti-1355 171 4 struthers struthers PROPN dti-1355 171 5 a. a. NOUN dti-1355 171 6 the the DET dti-1355 171 7 role role NOUN dti-1355 171 8 of of ADP dti-1355 171 9 urate urate NOUN dti-1355 171 10 and and CCONJ dti-1355 171 11 xanthine xanthine NOUN dti-1355 171 12 oxidase oxidase NOUN dti-1355 171 13 in in ADP dti-1355 171 14 vascular vascular ADJ dti-1355 171 15 oxidative oxidative ADJ dti-1355 171 16 stress stress NOUN dti-1355 171 17 : : PUNCT dti-1355 171 18 future future ADJ dti-1355 171 19 directions direction NOUN dti-1355 171 20 . . PUNCT dti-1355 172 1 ther ther PROPN dti-1355 172 2 clin clin PROPN dti-1355 172 3 risk risk NOUN dti-1355 172 4 manag manag NOUN dti-1355 172 5 . . PUNCT dti-1355 173 1 2009;5:799–803 2009;5:799–803 NUM dti-1355 173 2 . . NOUN dti-1355 174 1 19 19 NUM dti-1355 174 2 . . PUNCT dti-1355 174 3 malik malik PROPN dti-1355 174 4 uz uz PROPN dti-1355 174 5 , , PUNCT dti-1355 174 6 hundley hundley PROPN dti-1355 174 7 nj nj PROPN dti-1355 174 8 , , PUNCT dti-1355 174 9 romero romero PROPN dti-1355 174 10 g g PROPN dti-1355 174 11 , , PUNCT dti-1355 174 12 et et PROPN dti-1355 174 13     SPACE dti-1355 174 14 al al PROPN dti-1355 174 15 . . PROPN dti-1355 174 16 febuxostat febuxostat NOUN dti-1355 174 17 inhibition inhibition NOUN dti-1355 174 18 of of ADP dti-1355 174 19 endothelialbound endothelialbound PROPN dti-1355 174 20 xo xo PROPN dti-1355 174 21 : : PUNCT dti-1355 174 22 implication implication NOUN dti-1355 174 23 for for ADP dti-1355 174 24 targeting target VERB dti-1355 174 25 vascular vascular ADJ dti-1355 174 26 ros ros NOUN dti-1355 174 27 production production NOUN dti-1355 174 28 . . PUNCT dti-1355 175 1 free free ADJ dti-1355 175 2 radic radic ADJ dti-1355 175 3 biol biol PROPN dti-1355 175 4 med me VERB dti-1355 175 5 . . PUNCT dti-1355 176 1 2011;51(1):179–184 2011;51(1):179–184 X dti-1355 176 2 . . PROPN dti-1355 176 3 20 20 NUM dti-1355 176 4 . . PUNCT dti-1355 177 1 sezai sezai VERB dti-1355 177 2 a a DET dti-1355 177 3 , , PUNCT dti-1355 177 4 soma soma PROPN dti-1355 177 5 m m PROPN dti-1355 177 6 , , PUNCT dti-1355 177 7 nakata nakata PROPN dti-1355 177 8 k k PROPN dti-1355 177 9 , , PUNCT dti-1355 177 10 et et PROPN dti-1355 177 11     SPACE dti-1355 177 12 al al PROPN dti-1355 177 13 . . PROPN dti-1355 177 14 comparison comparison NOUN dti-1355 177 15 of of ADP dti-1355 177 16 febuxostat febuxostat NOUN dti-1355 177 17 and and CCONJ dti-1355 177 18 allopurinol allopurinol VERB dti-1355 177 19 for for ADP dti-1355 177 20 hyperuricemia hyperuricemia NOUN dti-1355 177 21 in in ADP dti-1355 177 22 cardiac cardiac ADJ dti-1355 177 23 surgery surgery NOUN dti-1355 177 24 patients patient NOUN dti-1355 177 25 ( ( PUNCT dti-1355 177 26 nu nu NOUN dti-1355 177 27 - - PUNCT dti-1355 177 28 flash flash NOUN dti-1355 177 29 trial trial NOUN dti-1355 177 30 ) ) PUNCT dti-1355 177 31 . . PUNCT dti-1355 178 1 circ circ PROPN dti-1355 178 2 j. j. PROPN dti-1355 178 3 2013 2013 NUM dti-1355 178 4 ; ; PUNCT dti-1355 178 5 77(8):2043–2049 77(8):2043–2049 X dti-1355 178 6 . . NOUN dti-1355 178 7 21 21 NUM dti-1355 178 8 . . PUNCT dti-1355 179 1 himmelfarb himmelfarb PROPN dti-1355 179 2 j. j. PROPN dti-1355 179 3 uremic uremic ADJ dti-1355 179 4 toxicity toxicity NOUN dti-1355 179 5 , , PUNCT dti-1355 179 6 oxidative oxidative ADJ dti-1355 179 7 stress stress NOUN dti-1355 179 8 , , PUNCT dti-1355 179 9 and and CCONJ dti-1355 179 10 hemodialysis hemodialysis NOUN dti-1355 179 11 as as ADP dti-1355 179 12 renal renal ADJ dti-1355 179 13 replacement replacement NOUN dti-1355 179 14 therapy therapy NOUN dti-1355 179 15 . . PUNCT dti-1355 180 1 semin semin PROPN dti-1355 180 2 dial dial PROPN dti-1355 180 3 . . PUNCT dti-1355 181 1 2009;22(6):636–643 2009;22(6):636–643 X dti-1355 181 2 . . NOUN dti-1355 182 1 22 22 NUM dti-1355 182 2 . . PUNCT dti-1355 183 1 griffiths griffiths PROPN dti-1355 183 2 hr hr PROPN dti-1355 183 3 , , PUNCT dti-1355 183 4 dias dias PROPN dti-1355 183 5 ih ih PROPN dti-1355 183 6 , , PUNCT dti-1355 183 7 willetts willett VERB dti-1355 183 8 rs rs PROPN dti-1355 183 9 , , PUNCT dti-1355 183 10 devitt devitt PROPN dti-1355 183 11 a. a. NOUN dti-1355 183 12 redox redox PROPN dti-1355 183 13 regulation regulation NOUN dti-1355 183 14 of of ADP dti-1355 183 15 protein protein NOUN dti-1355 183 16 damage damage NOUN dti-1355 183 17 in in ADP dti-1355 183 18 plasma plasma NOUN dti-1355 183 19 . . PUNCT dti-1355 184 1 redox redox ADJ dti-1355 184 2 biol biol PROPN dti-1355 184 3 . . PUNCT dti-1355 185 1 2014;2:430–435 2014;2:430–435 NUM dti-1355 185 2 . . PUNCT dti-1355 186 1 23 23 NUM dti-1355 186 2 . . PUNCT dti-1355 187 1 massy massy PROPN dti-1355 187 2 za za PROPN dti-1355 187 3 , , PUNCT dti-1355 187 4 stenvinkel stenvinkel NOUN dti-1355 187 5 p p NOUN dti-1355 187 6 , , PUNCT dti-1355 187 7 drueke drueke ADJ dti-1355 187 8 tb tb NOUN dti-1355 187 9 . . PUNCT dti-1355 188 1 the the DET dti-1355 188 2 role role NOUN dti-1355 188 3 of of ADP dti-1355 188 4 oxidative oxidative ADJ dti-1355 188 5 stress stress NOUN dti-1355 188 6 in in ADP dti-1355 188 7 chronic chronic ADJ dti-1355 188 8 kidney kidney NOUN dti-1355 188 9 disease disease NOUN dti-1355 188 10 . . PUNCT dti-1355 189 1 semin semin PROPN dti-1355 189 2 dial dial PROPN dti-1355 189 3 . . PUNCT dti-1355 190 1 2009;22(4):405–408 2009;22(4):405–408 NUM dti-1355 190 2 . . PUNCT dti-1355 191 1 24 24 NUM dti-1355 191 2 . . PUNCT dti-1355 192 1 halliwell halliwell PROPN dti-1355 192 2 b b PROPN dti-1355 192 3 , , PUNCT dti-1355 192 4 whiteman whiteman ADJ dti-1355 192 5 m. m. NOUN dti-1355 192 6 measuring measure VERB dti-1355 192 7 reactive reactive ADJ dti-1355 192 8 species specie NOUN dti-1355 192 9 and and CCONJ dti-1355 192 10 oxidative oxidative ADJ dti-1355 192 11 damage damage NOUN dti-1355 192 12 in in ADP dti-1355 192 13 vivo vivo NOUN dti-1355 192 14 and and CCONJ dti-1355 192 15 in in ADP dti-1355 192 16 cell cell NOUN dti-1355 192 17 culture culture NOUN dti-1355 192 18 : : PUNCT dti-1355 192 19 how how SCONJ dti-1355 192 20 should should AUX dti-1355 192 21 you you PRON dti-1355 192 22 do do VERB dti-1355 192 23 it it PRON dti-1355 192 24 and and CCONJ dti-1355 192 25 what what PRON dti-1355 192 26 do do AUX dti-1355 192 27 the the DET dti-1355 192 28 results result NOUN dti-1355 192 29 mean mean VERB dti-1355 192 30 ? ? PUNCT dti-1355 193 1 br br PROPN dti-1355 194 1 j j PROPN dti-1355 194 2 pharmacol pharmacol PROPN dti-1355 194 3 . . PUNCT dti-1355 195 1 2004;142(2):231–255 2004;142(2):231–255 NUM dti-1355 195 2 . . X dti-1355 195 3 25 25 NUM dti-1355 195 4 . . PUNCT dti-1355 196 1 jalalzadeh jalalzadeh PROPN dti-1355 196 2 m m PROPN dti-1355 196 3 , , PUNCT dti-1355 196 4 nurcheshmeh nurcheshmeh VERB dti-1355 196 5 z z NOUN dti-1355 196 6 , , PUNCT dti-1355 196 7 mohammadi mohammadi ADJ dti-1355 196 8 r r NOUN dti-1355 196 9 , , PUNCT dti-1355 196 10 mousavinasab mousavinasab ADJ dti-1355 196 11 n n CCONJ dti-1355 196 12 , , PUNCT dti-1355 196 13 ghadiani ghadiani PROPN dti-1355 196 14 mh mh PROPN dti-1355 196 15 . . PUNCT dti-1355 197 1 the the DET dti-1355 197 2 effect effect NOUN dti-1355 197 3 of of ADP dti-1355 197 4 allopurinol allopurinol NOUN dti-1355 197 5 on on ADP dti-1355 197 6 lowering lower VERB dti-1355 197 7 blood blood NOUN dti-1355 197 8 pressure pressure NOUN dti-1355 197 9 in in ADP dti-1355 197 10 hemodialysis hemodialysis NOUN dti-1355 197 11 patients patient NOUN dti-1355 197 12 with with ADP dti-1355 197 13 hyperuricemia hyperuricemia NOUN dti-1355 197 14 . . PUNCT dti-1355 198 1 j j PROPN dti-1355 198 2 res res PROPN dti-1355 198 3 med med PROPN dti-1355 198 4 sci sci PROPN dti-1355 198 5 . . PUNCT dti-1355 199 1 2012;17(11):1039–1046 2012;17(11):1039–1046 NUM dti-1355 199 2 . . PROPN dti-1355 200 1 26 26 NUM dti-1355 200 2 . . PUNCT dti-1355 201 1 agarwal agarwal PROPN dti-1355 201 2 v v PROPN dti-1355 201 3 , , PUNCT dti-1355 201 4 hans hans PROPN dti-1355 201 5 n n CCONJ dti-1355 201 6 , , PUNCT dti-1355 201 7 messerli messerli PROPN dti-1355 201 8 fh fh PROPN dti-1355 201 9 . . PROPN dti-1355 201 10 effect effect NOUN dti-1355 201 11 of of ADP dti-1355 201 12 allopurinol allopurinol NOUN dti-1355 201 13 on on ADP dti-1355 201 14 blood blood NOUN dti-1355 201 15 pressure pressure NOUN dti-1355 201 16 : : PUNCT dti-1355 201 17 a a DET dti-1355 201 18 systematic systematic ADJ dti-1355 201 19 review review NOUN dti-1355 201 20 and and CCONJ dti-1355 201 21 meta meta ADJ dti-1355 201 22 - - PUNCT dti-1355 201 23 analysis analysis NOUN dti-1355 201 24 . . PUNCT dti-1355 202 1 j j PROPN dti-1355 202 2 clin clin PROPN dti-1355 202 3 hypertens hyperten VERB dti-1355 202 4 ( ( PUNCT dti-1355 202 5 greenwich greenwich PROPN dti-1355 202 6 ) ) PUNCT dti-1355 202 7 . . PUNCT dti-1355 203 1 2013;15(6 2013;15(6 NUM dti-1355 203 2 ): ): PUNCT dti-1355 203 3 435–442 435–442 NUM dti-1355 203 4 . . PUNCT dti-1355 203 5 27 27 NUM dti-1355 203 6 . . PUNCT dti-1355 204 1 argilés argilés PROPN dti-1355 204 2 a a DET dti-1355 204 3 , , PUNCT dti-1355 204 4 mourad mourad PROPN dti-1355 204 5 g g PROPN dti-1355 204 6 , , PUNCT dti-1355 204 7 mion mion PROPN dti-1355 204 8 c. c. PROPN dti-1355 204 9 seasonal seasonal ADJ dti-1355 204 10 changes change NOUN dti-1355 204 11 in in ADP dti-1355 204 12 blood blood NOUN dti-1355 204 13 pressure pressure NOUN dti-1355 204 14 in in ADP dti-1355 204 15 patients patient NOUN dti-1355 204 16 with with ADP dti-1355 204 17 end end NOUN dti-1355 204 18 - - PUNCT dti-1355 204 19 stage stage NOUN dti-1355 204 20 renal renal ADJ dti-1355 204 21 disease disease NOUN dti-1355 204 22 treated treat VERB dti-1355 204 23 with with ADP dti-1355 204 24 hemodialysis hemodialysis NOUN dti-1355 204 25 . . PUNCT dti-1355 205 1 n n PRON dti-1355 205 2 engl engl PROPN dti-1355 205 3 j j PROPN dti-1355 205 4 med med PROPN dti-1355 205 5 . . PUNCT dti-1355 206 1 1998 1998 NUM dti-1355 206 2 ; ; PUNCT dti-1355 207 1 339(19):1364–1370 339(19):1364–1370 NUM dti-1355 207 2 . . PUNCT dti-1355 208 1 28 28 NUM dti-1355 208 2 . . PUNCT dti-1355 209 1 murea murea PROPN dti-1355 209 2 m. m. PROPN dti-1355 209 3 advanced advanced ADJ dti-1355 209 4 kidney kidney NOUN dti-1355 209 5 failure failure NOUN dti-1355 209 6 and and CCONJ dti-1355 209 7 hyperuricemia hyperuricemia NOUN dti-1355 209 8 . . PUNCT dti-1355 210 1 adv adv PROPN dti-1355 210 2 chronic chronic ADJ dti-1355 210 3 kidney kidney PROPN dti-1355 210 4 dis dis PROPN dti-1355 210 5 . . PUNCT dti-1355 211 1 2012;19(6):419–424 2012;19(6):419–424 NUM dti-1355 211 2 . . PUNCT dti-1355 211 3 http://www.la-press.com http://www.la-press.com X dti-1355 211 4 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN