id sid tid token lemma pos dti-1357 1 1 51drug 51drug NOUN dti-1357 1 2 target target NOUN dti-1357 1 3 insights insight VERB dti-1357 1 4 2014:8 2014:8 NUM dti-1357 1 5 open open ADJ dti-1357 1 6 access access NOUN dti-1357 1 7 : : PUNCT dti-1357 1 8 full full ADJ dti-1357 1 9 open open ADJ dti-1357 1 10 access access NOUN dti-1357 1 11 to to ADP dti-1357 1 12 this this PRON dti-1357 1 13 and and CCONJ dti-1357 1 14 thousands thousand NOUN dti-1357 1 15 of of ADP dti-1357 1 16 other other ADJ dti-1357 1 17 papers paper NOUN dti-1357 1 18 at at ADP dti-1357 1 19 http://www.la-press.com http://www.la-press.com X dti-1357 1 20 . . PUNCT dti-1357 2 1 drug drug NOUN dti-1357 2 2 target target NOUN dti-1357 2 3 insights insight NOUN dti-1357 2 4 genome genome NOUN dti-1357 2 5 - - PUNCT dti-1357 2 6 wide wide ADJ dti-1357 2 7 analysis analysis NOUN dti-1357 2 8 of of ADP dti-1357 2 9 mycoplasma mycoplasma NOUN dti-1357 2 10 hominis hominis NOUN dti-1357 2 11 for for ADP dti-1357 2 12 the the DET dti-1357 2 13 identification identification NOUN dti-1357 2 14 of of ADP dti-1357 2 15 putative putative ADJ dti-1357 2 16 therapeutic therapeutic ADJ dti-1357 2 17 targets target NOUN dti-1357 2 18 md md PROPN dti-1357 2 19 . . PROPN dti-1357 2 20 masud masud PROPN dti-1357 2 21 parvege parvege PROPN dti-1357 2 22 , , PUNCT dti-1357 2 23 monzilur monzilur PROPN dti-1357 2 24 rahman rahman PROPN dti-1357 2 25 and and CCONJ dti-1357 2 26 mohammad mohammad PROPN dti-1357 2 27 shahnoor shahnoor PROPN dti-1357 2 28 hossain hossain PROPN dti-1357 2 29 department department PROPN dti-1357 2 30 of of ADP dti-1357 2 31 genetic genetic ADJ dti-1357 2 32 engineering engineering NOUN dti-1357 2 33 & & CCONJ dti-1357 2 34 biotechnology biotechnology NOUN dti-1357 2 35 , , PUNCT dti-1357 2 36 university university NOUN dti-1357 2 37 of of ADP dti-1357 2 38 dhaka dhaka PROPN dti-1357 2 39 , , PUNCT dti-1357 2 40 dhaka dhaka PROPN dti-1357 2 41 , , PUNCT dti-1357 2 42 bangladesh bangladesh PROPN dti-1357 2 43 . . PUNCT dti-1357 3 1 abstr abstr PROPN dti-1357 3 2 act act PROPN dti-1357 3 3 : : PUNCT dti-1357 3 4 ever ever ADV dti-1357 3 5 increasing increase VERB dti-1357 3 6 propensity propensity NOUN dti-1357 3 7 of of ADP dti-1357 3 8 antibiotic antibiotic ADJ dti-1357 3 9 resistance resistance NOUN dti-1357 3 10 among among ADP dti-1357 3 11 pathogenic pathogenic ADJ dti-1357 3 12 bacteria bacteria NOUN dti-1357 3 13 raises raise VERB dti-1357 3 14 the the DET dti-1357 3 15 demand demand NOUN dti-1357 3 16 for for ADP dti-1357 3 17 the the DET dti-1357 3 18 development development NOUN dti-1357 3 19 of of ADP dti-1357 3 20 novel novel ADJ dti-1357 3 21 therapeutic therapeutic ADJ dti-1357 3 22 agents agent NOUN dti-1357 3 23 to to PART dti-1357 3 24 control control VERB dti-1357 3 25 this this DET dti-1357 3 26 grave grave ADJ dti-1357 3 27 problem problem NOUN dti-1357 3 28 . . PUNCT dti-1357 4 1 advances advance NOUN dti-1357 4 2 in in ADP dti-1357 4 3 the the DET dti-1357 4 4 field field NOUN dti-1357 4 5 of of ADP dti-1357 4 6 bioinformatics bioinformatics NOUN dti-1357 4 7 , , PUNCT dti-1357 4 8 genomics genomic NOUN dti-1357 4 9 , , PUNCT dti-1357 4 10 and and CCONJ dti-1357 4 11 proteomics proteomic NOUN dti-1357 4 12 have have AUX dti-1357 4 13 greatly greatly ADV dti-1357 4 14 facilitated facilitate VERB dti-1357 4 15 the the DET dti-1357 4 16 discovery discovery NOUN dti-1357 4 17 of of ADP dti-1357 4 18 alternative alternative ADJ dti-1357 4 19 drugs drug NOUN dti-1357 4 20 by by ADP dti-1357 4 21 swift swift ADJ dti-1357 4 22 identification identification NOUN dti-1357 4 23 of of ADP dti-1357 4 24 new new ADJ dti-1357 4 25 drug drug NOUN dti-1357 4 26 targets target NOUN dti-1357 4 27 . . PUNCT dti-1357 5 1 in in ADP dti-1357 5 2 the the DET dti-1357 5 3 present present ADJ dti-1357 5 4 study study NOUN dti-1357 5 5 , , PUNCT dti-1357 5 6 we we PRON dti-1357 5 7 employed employ VERB dti-1357 5 8 comparative comparative ADJ dti-1357 5 9 genomics genomic NOUN dti-1357 5 10 and and CCONJ dti-1357 5 11 metabolic metabolic NOUN dti-1357 5 12 pathway pathway NOUN dti-1357 5 13 analysis analysis NOUN dti-1357 5 14 with with ADP dti-1357 5 15 an an DET dti-1357 5 16 aim aim NOUN dti-1357 5 17 of of ADP dti-1357 5 18 identifying identify VERB dti-1357 5 19 therapeutic therapeutic ADJ dti-1357 5 20 targets target NOUN dti-1357 5 21 in in ADP dti-1357 5 22 mycoplasma mycoplasma NOUN dti-1357 5 23 hominis hominis NOUN dti-1357 5 24 . . PUNCT dti-1357 6 1 our our PRON dti-1357 6 2 study study NOUN dti-1357 6 3 has have AUX dti-1357 6 4 revealed reveal VERB dti-1357 6 5 40 40 NUM dti-1357 6 6 annotated annotate VERB dti-1357 6 7 metabolic metabolic NOUN dti-1357 6 8 pathways pathway NOUN dti-1357 6 9 , , PUNCT dti-1357 6 10 including include VERB dti-1357 6 11 five five NUM dti-1357 6 12 unique unique ADJ dti-1357 6 13 pathways pathway NOUN dti-1357 6 14 of of ADP dti-1357 6 15 m. m. NOUN dti-1357 6 16 hominis hominis PROPN dti-1357 6 17 . . PUNCT dti-1357 7 1 our our PRON dti-1357 7 2 study study NOUN dti-1357 7 3 also also ADV dti-1357 7 4 identified identify VERB dti-1357 7 5 179 179 NUM dti-1357 7 6 essential essential ADJ dti-1357 7 7 proteins protein NOUN dti-1357 7 8 , , PUNCT dti-1357 7 9 including include VERB dti-1357 7 10 59 59 NUM dti-1357 7 11 proteins protein NOUN dti-1357 7 12 having have VERB dti-1357 7 13 no no DET dti-1357 7 14 similarity similarity NOUN dti-1357 7 15 with with ADP dti-1357 7 16 human human ADJ dti-1357 7 17 proteins protein NOUN dti-1357 7 18 . . PUNCT dti-1357 8 1 further far ADV dti-1357 8 2 filtering filter VERB dti-1357 8 3 by by ADP dti-1357 8 4 molecular molecular ADJ dti-1357 8 5 weight weight NOUN dti-1357 8 6 , , PUNCT dti-1357 8 7 subcellular subcellular ADJ dti-1357 8 8 localization localization NOUN dti-1357 8 9 , , PUNCT dti-1357 8 10 functional functional ADJ dti-1357 8 11 analysis analysis NOUN dti-1357 8 12 , , PUNCT dti-1357 8 13 and and CCONJ dti-1357 8 14 protein protein NOUN dti-1357 8 15 network network NOUN dti-1357 8 16 interaction interaction NOUN dti-1357 8 17 , , PUNCT dti-1357 8 18 we we PRON dti-1357 8 19 identified identify VERB dti-1357 8 20 57 57 NUM dti-1357 8 21 putative putative ADJ dti-1357 8 22 candidates candidate NOUN dti-1357 8 23 for for ADP dti-1357 8 24 which which PRON dti-1357 8 25 new new ADJ dti-1357 8 26 drugs drug NOUN dti-1357 8 27 can can AUX dti-1357 8 28 be be AUX dti-1357 8 29 developed develop VERB dti-1357 8 30 . . PUNCT dti-1357 9 1 druggability druggability NOUN dti-1357 9 2 analysis analysis NOUN dti-1357 9 3 for for ADP dti-1357 9 4 each each PRON dti-1357 9 5 of of ADP dti-1357 9 6 the the DET dti-1357 9 7 identified identify VERB dti-1357 9 8 targets target NOUN dti-1357 9 9 has have AUX dti-1357 9 10 prioritized prioritize VERB dti-1357 9 11 16 16 NUM dti-1357 9 12 proteins protein NOUN dti-1357 9 13 as as ADP dti-1357 9 14 suitable suitable ADJ dti-1357 9 15 for for ADP dti-1357 9 16 potential potential ADJ dti-1357 9 17 drug drug NOUN dti-1357 9 18 development development NOUN dti-1357 9 19 . . PUNCT dti-1357 10 1 key key ADJ dti-1357 10 2 words word NOUN dti-1357 10 3 : : PUNCT dti-1357 10 4 mycoplasma mycoplasma NOUN dti-1357 10 5 hominis hominis NOUN dti-1357 10 6 , , PUNCT dti-1357 10 7 drug drug NOUN dti-1357 10 8 targets target NOUN dti-1357 10 9 , , PUNCT dti-1357 10 10 bioinformatics bioinformatics NOUN dti-1357 10 11 , , PUNCT dti-1357 10 12 genomics genomic NOUN dti-1357 10 13 , , PUNCT dti-1357 10 14 proteomics proteomic NOUN dti-1357 10 15 citation citation NOUN dti-1357 10 16 : : PUNCT dti-1357 10 17 parvege parvege PROPN dti-1357 10 18 et et PROPN dti-1357 10 19 al al PROPN dti-1357 10 20 . . PUNCT dti-1357 10 21 genome genome NOUN dti-1357 10 22 - - PUNCT dti-1357 10 23 wide wide ADJ dti-1357 10 24 analysis analysis NOUN dti-1357 10 25 of of ADP dti-1357 10 26 mycoplasma mycoplasma NOUN dti-1357 10 27 hominis hominis NOUN dti-1357 10 28 for for ADP dti-1357 10 29 the the DET dti-1357 10 30 identification identification NOUN dti-1357 10 31 of of ADP dti-1357 10 32 putative putative ADJ dti-1357 10 33 therapeutic therapeutic ADJ dti-1357 10 34 targets target NOUN dti-1357 10 35 . . PUNCT dti-1357 11 1 drug drug NOUN dti-1357 11 2 target target NOUN dti-1357 11 3 insights insight VERB dti-1357 11 4 2014:8 2014:8 NUM dti-1357 11 5 51–62 51–62 NUM dti-1357 11 6 doi:10.4137 doi:10.4137 NOUN dti-1357 11 7 / / SYM dti-1357 11 8 dti.s19728 dti.s19728 NOUN dti-1357 11 9 . . PUNCT dti-1357 12 1 received receive VERB dti-1357 12 2 : : PUNCT dti-1357 12 3 august august PROPN dti-1357 12 4 31 31 NUM dti-1357 12 5 , , PUNCT dti-1357 12 6 2014 2014 NUM dti-1357 12 7 . . PUNCT dti-1357 13 1 resubmitted resubmitte VERB dti-1357 13 2 : : PUNCT dti-1357 13 3 november november PROPN dti-1357 13 4 6 6 NUM dti-1357 13 5 , , PUNCT dti-1357 13 6 2014 2014 NUM dti-1357 13 7 . . PUNCT dti-1357 14 1 accepted accept VERB dti-1357 14 2 for for ADP dti-1357 14 3 publication publication NOUN dti-1357 14 4 : : PUNCT dti-1357 14 5 november november PROPN dti-1357 14 6 10 10 NUM dti-1357 14 7 , , PUNCT dti-1357 14 8 2014 2014 NUM dti-1357 14 9 . . PUNCT dti-1357 15 1 academic academic ADJ dti-1357 15 2 editor editor NOUN dti-1357 15 3 : : PUNCT dti-1357 15 4 anuj anuj PROPN dti-1357 15 5 chauhan chauhan PROPN dti-1357 15 6 , , PUNCT dti-1357 15 7 editor editor NOUN dti-1357 15 8 in in ADP dti-1357 15 9 chief chief ADJ dti-1357 15 10 type type NOUN dti-1357 15 11 : : PUNCT dti-1357 15 12 original original ADJ dti-1357 15 13 research research NOUN dti-1357 15 14 funding funding NOUN dti-1357 15 15 : : PUNCT dti-1357 15 16 this this DET dti-1357 15 17 work work NOUN dti-1357 15 18 was be AUX dti-1357 15 19 supported support VERB dti-1357 15 20 by by ADP dti-1357 15 21 the the DET dti-1357 15 22 research research NOUN dti-1357 15 23 grant grant NOUN dti-1357 15 24 provided provide VERB dti-1357 15 25 to to ADP dti-1357 15 26 dr dr PROPN dti-1357 15 27 . . PROPN dti-1357 15 28 mohammad mohammad PROPN dti-1357 15 29 shahnoor shahnoor PROPN dti-1357 15 30 hossain hossain PROPN dti-1357 15 31 from from ADP dti-1357 15 32 biotechnology biotechnology NOUN dti-1357 15 33 research research NOUN dti-1357 15 34 centre centre NOUN dti-1357 15 35 , , PUNCT dti-1357 15 36 university university NOUN dti-1357 15 37 of of ADP dti-1357 15 38 dhaka dhaka PROPN dti-1357 15 39 . . PUNCT dti-1357 16 1 the the DET dti-1357 16 2 authors author NOUN dti-1357 16 3 confirm confirm VERB dti-1357 16 4 that that SCONJ dti-1357 16 5 the the DET dti-1357 16 6 funder funder NOUN dti-1357 16 7 had have VERB dti-1357 16 8 no no DET dti-1357 16 9 influence influence NOUN dti-1357 16 10 over over ADP dti-1357 16 11 the the DET dti-1357 16 12 study study NOUN dti-1357 16 13 design design NOUN dti-1357 16 14 , , PUNCT dti-1357 16 15 content content NOUN dti-1357 16 16 of of ADP dti-1357 16 17 the the DET dti-1357 16 18 article article NOUN dti-1357 16 19 , , PUNCT dti-1357 16 20 or or CCONJ dti-1357 16 21 selection selection NOUN dti-1357 16 22 of of ADP dti-1357 16 23 this this DET dti-1357 16 24 journal journal NOUN dti-1357 16 25 . . PUNCT dti-1357 17 1 competing compete VERB dti-1357 17 2 interests interest NOUN dti-1357 17 3 : : PUNCT dti-1357 17 4 authors author NOUN dti-1357 17 5 disclose disclose VERB dti-1357 17 6 no no DET dti-1357 17 7 potential potential ADJ dti-1357 17 8 conflicts conflict NOUN dti-1357 17 9 of of ADP dti-1357 17 10 interest interest NOUN dti-1357 17 11 . . PUNCT dti-1357 18 1 copyright copyright NOUN dti-1357 18 2 : : PUNCT dti-1357 18 3 © © PROPN dti-1357 18 4 the the DET dti-1357 18 5 authors author NOUN dti-1357 18 6 , , PUNCT dti-1357 18 7 publisher publisher NOUN dti-1357 18 8 and and CCONJ dti-1357 18 9 licensee licensee NOUN dti-1357 18 10 libertas liberta NOUN dti-1357 18 11 academica academica PROPN dti-1357 18 12 limited limit VERB dti-1357 18 13 . . PUNCT dti-1357 19 1 this this PRON dti-1357 19 2 is be AUX dti-1357 19 3 an an DET dti-1357 19 4 open open ADJ dti-1357 19 5 - - PUNCT dti-1357 19 6 access access NOUN dti-1357 19 7 article article NOUN dti-1357 19 8 distributed distribute VERB dti-1357 19 9 under under ADP dti-1357 19 10 the the DET dti-1357 19 11 terms term NOUN dti-1357 19 12 of of ADP dti-1357 19 13 the the DET dti-1357 19 14 creative creative ADJ dti-1357 19 15 commons common NOUN dti-1357 19 16 cc cc NOUN dti-1357 19 17 - - PUNCT dti-1357 19 18 by by ADP dti-1357 19 19 - - PUNCT dti-1357 19 20 nc nc PROPN dti-1357 19 21 3.0 3.0 NUM dti-1357 19 22 license license NOUN dti-1357 19 23 . . PUNCT dti-1357 20 1 correspondence correspondence NOUN dti-1357 20 2 : : PUNCT dti-1357 20 3 mshahnoor@du.ac.bd mshahnoor@du.ac.bd PROPN dti-1357 20 4 paper paper PROPN dti-1357 20 5 subject subject NOUN dti-1357 20 6 to to ADP dti-1357 20 7 independent independent ADJ dti-1357 20 8 expert expert NOUN dti-1357 20 9 blind blind ADJ dti-1357 20 10 peer peer NOUN dti-1357 20 11 review review NOUN dti-1357 20 12 by by ADP dti-1357 20 13 minimum minimum NOUN dti-1357 20 14 of of ADP dti-1357 20 15 two two NUM dti-1357 20 16 reviewers reviewer NOUN dti-1357 20 17 . . PUNCT dti-1357 21 1 all all DET dti-1357 21 2 editorial editorial ADJ dti-1357 21 3 decisions decision NOUN dti-1357 21 4 made make VERB dti-1357 21 5 by by ADP dti-1357 21 6 independent independent ADJ dti-1357 21 7 academic academic ADJ dti-1357 21 8 editor editor NOUN dti-1357 21 9 . . PUNCT dti-1357 22 1 upon upon SCONJ dti-1357 22 2 submission submission NOUN dti-1357 22 3 manuscript manuscript NOUN dti-1357 22 4 was be AUX dti-1357 22 5 subject subject ADJ dti-1357 22 6 to to ADP dti-1357 22 7 anti anti ADJ dti-1357 22 8 - - NOUN dti-1357 22 9 plagiarism plagiarism ADJ dti-1357 22 10 scanning scanning NOUN dti-1357 22 11 . . PUNCT dti-1357 23 1 prior prior ADV dti-1357 23 2 to to ADP dti-1357 23 3 publication publication NOUN dti-1357 23 4 all all DET dti-1357 23 5 authors author NOUN dti-1357 23 6 have have AUX dti-1357 23 7 given give VERB dti-1357 23 8 signed sign VERB dti-1357 23 9 confirmation confirmation NOUN dti-1357 23 10 of of ADP dti-1357 23 11 agreement agreement NOUN dti-1357 23 12 to to ADP dti-1357 23 13 article article NOUN dti-1357 23 14 publication publication NOUN dti-1357 23 15 and and CCONJ dti-1357 23 16 compliance compliance NOUN dti-1357 23 17 with with ADP dti-1357 23 18 all all DET dti-1357 23 19 applicable applicable ADJ dti-1357 23 20 ethical ethical ADJ dti-1357 23 21 and and CCONJ dti-1357 23 22 legal legal ADJ dti-1357 23 23 requirements requirement NOUN dti-1357 23 24 , , PUNCT dti-1357 23 25 including include VERB dti-1357 23 26 the the DET dti-1357 23 27 accuracy accuracy NOUN dti-1357 23 28 of of ADP dti-1357 23 29 author author NOUN dti-1357 23 30 and and CCONJ dti-1357 23 31 contributor contributor NOUN dti-1357 23 32 information information NOUN dti-1357 23 33 , , PUNCT dti-1357 23 34 disclosure disclosure NOUN dti-1357 23 35 of of ADP dti-1357 23 36 competing compete VERB dti-1357 23 37 interests interest NOUN dti-1357 23 38 and and CCONJ dti-1357 23 39 funding funding NOUN dti-1357 23 40 sources source NOUN dti-1357 23 41 , , PUNCT dti-1357 23 42 compliance compliance NOUN dti-1357 23 43 with with ADP dti-1357 23 44 ethical ethical ADJ dti-1357 23 45 requirements requirement NOUN dti-1357 23 46 relating relate VERB dti-1357 23 47 to to ADP dti-1357 23 48 human human ADJ dti-1357 23 49 and and CCONJ dti-1357 23 50 animal animal NOUN dti-1357 23 51 study study NOUN dti-1357 23 52 participants participant NOUN dti-1357 23 53 , , PUNCT dti-1357 23 54 and and CCONJ dti-1357 23 55 compliance compliance NOUN dti-1357 23 56 with with ADP dti-1357 23 57 any any DET dti-1357 23 58 copyright copyright NOUN dti-1357 23 59 requirements requirement NOUN dti-1357 23 60 of of ADP dti-1357 23 61 third third ADJ dti-1357 23 62 parties party NOUN dti-1357 23 63 . . PUNCT dti-1357 24 1 this this DET dti-1357 24 2 journal journal NOUN dti-1357 24 3 is be AUX dti-1357 24 4 a a DET dti-1357 24 5 member member NOUN dti-1357 24 6 of of ADP dti-1357 24 7 the the DET dti-1357 24 8 committee committee NOUN dti-1357 24 9 on on ADP dti-1357 24 10 publication publication NOUN dti-1357 24 11 ethics ethic NOUN dti-1357 24 12 ( ( PUNCT dti-1357 24 13 cope cope PROPN dti-1357 24 14 ) ) PUNCT dti-1357 24 15 . . PUNCT dti-1357 25 1 introduction introduction NOUN dti-1357 25 2 mycoplasmas mycoplasmas PROPN dti-1357 25 3 are be AUX dti-1357 25 4 cell cell NOUN dti-1357 25 5 wall wall NOUN dti-1357 25 6 - - PUNCT dti-1357 25 7 deficient deficient ADJ dti-1357 25 8 , , PUNCT dti-1357 25 9 smallest small ADJ dti-1357 25 10 , , PUNCT dti-1357 25 11 free free ADJ dti-1357 25 12 - - PUNCT dti-1357 25 13 living live VERB dti-1357 25 14 organisms organism NOUN dti-1357 25 15 , , PUNCT dti-1357 25 16 which which PRON dti-1357 25 17 are be AUX dti-1357 25 18 resistant resistant ADJ dti-1357 25 19 to to ADP dti-1357 25 20 many many ADJ dti-1357 25 21 commonly commonly ADV dti-1357 25 22 used use VERB dti-1357 25 23 antimicrobial antimicrobial ADJ dti-1357 25 24 agents.1 agents.1 NOUN dti-1357 25 25 although although SCONJ dti-1357 25 26 most most ADJ dti-1357 25 27 of of ADP dti-1357 25 28 the the DET dti-1357 25 29 mycoplasma mycoplasma NOUN dti-1357 25 30 are be AUX dti-1357 25 31 naturally naturally ADV dti-1357 25 32 found find VERB dti-1357 25 33 as as ADP dti-1357 25 34 commensals commensal NOUN dti-1357 25 35 in in ADP dti-1357 25 36 the the DET dti-1357 25 37 genitourinary genitourinary ADJ dti-1357 25 38 tract tract NOUN dti-1357 25 39 , , PUNCT dti-1357 25 40 three three NUM dti-1357 25 41 species specie NOUN dti-1357 25 42 are be AUX dti-1357 25 43 wellknown wellknown ADJ dti-1357 25 44 pathogens pathogen NOUN dti-1357 25 45 : : PUNCT dti-1357 25 46 mycoplasma mycoplasma VERB dti-1357 25 47 pneumoniae pneumoniae NOUN dti-1357 25 48 , , PUNCT dti-1357 25 49 m. m. NOUN dti-1357 25 50 hominis hominis NOUN dti-1357 25 51 , , PUNCT dti-1357 25 52 and and CCONJ dti-1357 25 53 m. m. NOUN dti-1357 25 54 genitalium.2 genitalium.2 PROPN dti-1357 25 55 to to PART dti-1357 25 56 lead lead VERB dti-1357 25 57 a a DET dti-1357 25 58 parasitic parasitic ADJ dti-1357 25 59 lifestyle lifestyle NOUN dti-1357 25 60 , , PUNCT dti-1357 25 61 m. m. NOUN dti-1357 25 62 hominis hominis PROPN dti-1357 25 63 resides reside VERB dti-1357 25 64 in in ADP dti-1357 25 65 the the DET dti-1357 25 66 urogenital urogenital ADJ dti-1357 25 67 tract tract NOUN dti-1357 25 68 of of ADP dti-1357 25 69 women woman NOUN dti-1357 25 70 and and CCONJ dti-1357 25 71 sexually sexually ADV dti-1357 25 72 active active ADJ dti-1357 25 73 men man NOUN dti-1357 25 74 where where SCONJ dti-1357 25 75 it it PRON dti-1357 25 76 gains gain VERB dti-1357 25 77 necessary necessary ADJ dti-1357 25 78 nutrients.3 nutrients.3 NOUN dti-1357 25 79 sometimes sometimes ADV dti-1357 25 80 , , PUNCT dti-1357 25 81 the the DET dti-1357 25 82 bacterium bacterium NOUN dti-1357 25 83 is be AUX dti-1357 25 84 found find VERB dti-1357 25 85 in in ADP dti-1357 25 86 a a DET dti-1357 25 87 symbiotic symbiotic ADJ dti-1357 25 88 relationship relationship NOUN dti-1357 25 89 with with ADP dti-1357 25 90 protozoa protozoan NOUN dti-1357 25 91 , , PUNCT dti-1357 25 92 trichomonas trichomona NOUN dti-1357 25 93 vaginalis vaginalis PROPN dti-1357 25 94 , , PUNCT dti-1357 25 95 an an DET dti-1357 25 96 event event NOUN dti-1357 25 97 that that PRON dti-1357 25 98 allows allow VERB dti-1357 25 99 for for ADP dti-1357 25 100 more more ADV dti-1357 25 101 successful successful ADJ dti-1357 25 102 transfer transfer NOUN dti-1357 25 103 of of ADP dti-1357 25 104 m. m. NOUN dti-1357 25 105 hominis hominis PROPN dti-1357 25 106 from from ADP dti-1357 25 107 one one NUM dti-1357 25 108 person person NOUN dti-1357 25 109 to to ADP dti-1357 25 110 another another PRON dti-1357 25 111 , , PUNCT dti-1357 25 112 and and CCONJ dti-1357 25 113 increases increase VERB dti-1357 25 114 its its PRON dti-1357 25 115 resistance resistance NOUN dti-1357 25 116 to to ADP dti-1357 25 117 antibiotics.3,4 antibiotics.3,4 VERB dti-1357 25 118 this this DET dti-1357 25 119 bacterium bacterium NOUN dti-1357 25 120 is be AUX dti-1357 25 121 the the DET dti-1357 25 122 causative causative ADJ dti-1357 25 123 agent agent NOUN dti-1357 25 124 of of ADP dti-1357 25 125 numerous numerous ADJ dti-1357 25 126 health health NOUN dti-1357 25 127 problems problem NOUN dti-1357 25 128 , , PUNCT dti-1357 25 129 such such ADJ dti-1357 25 130 as as ADP dti-1357 25 131 pelvic pelvic ADJ dti-1357 25 132 inflammatory inflammatory ADJ dti-1357 25 133 disease disease NOUN dti-1357 25 134 , , PUNCT dti-1357 25 135 bacterial bacterial ADJ dti-1357 25 136 vaginosis vaginosis NOUN dti-1357 25 137 , , PUNCT dti-1357 25 138 post post ADJ dti-1357 25 139 - - ADJ dti-1357 25 140 partum partum ADJ dti-1357 25 141 fever fever NOUN dti-1357 25 142 , , PUNCT dti-1357 25 143 and and CCONJ dti-1357 25 144 infertility infertility NOUN dti-1357 25 145 in in ADP dti-1357 25 146 females.2,5–7 females.2,5–7 NOUN dti-1357 25 147 in in ADP dti-1357 25 148 addition addition NOUN dti-1357 25 149 , , PUNCT dti-1357 25 150 m. m. NOUN dti-1357 25 151 hominis hominis PROPN dti-1357 25 152 is be AUX dti-1357 25 153 capable capable ADJ dti-1357 25 154 of of ADP dti-1357 25 155 causing cause VERB dti-1357 25 156 diseases disease NOUN dti-1357 25 157 of of ADP dti-1357 25 158 the the DET dti-1357 25 159 central central ADJ dti-1357 25 160 nervous nervous ADJ dti-1357 25 161 system system NOUN dti-1357 25 162 in in ADP dti-1357 25 163 newborn newborn ADJ dti-1357 25 164 babies8 babies8 NOUN dti-1357 25 165 and and CCONJ dti-1357 25 166 is be AUX dti-1357 25 167 associated associate VERB dti-1357 25 168 with with ADP dti-1357 25 169 prostate prostate NOUN dti-1357 25 170 cancer.9 cancer.9 PROPN dti-1357 25 171 currently currently ADV dti-1357 25 172 , , PUNCT dti-1357 25 173 antibiotics antibiotic NOUN dti-1357 25 174 are be AUX dti-1357 25 175 the the DET dti-1357 25 176 only only ADJ dti-1357 25 177 available available ADJ dti-1357 25 178 treatment treatment NOUN dti-1357 25 179 option option NOUN dti-1357 25 180 against against ADP dti-1357 25 181 m. m. NOUN dti-1357 25 182 hominis hominis PROPN dti-1357 25 183 infection infection NOUN dti-1357 25 184 . . PUNCT dti-1357 26 1 however however ADV dti-1357 26 2 , , PUNCT dti-1357 26 3 this this DET dti-1357 26 4 species specie NOUN dti-1357 26 5 is be AUX dti-1357 26 6 inherently inherently ADV dti-1357 26 7 resistant resistant ADJ dti-1357 26 8 to to ADP dti-1357 26 9 beta beta NOUN dti-1357 26 10 - - PUNCT dti-1357 26 11 lactam lactam NOUN dti-1357 26 12 group group NOUN dti-1357 26 13 antibiotics antibiotic NOUN dti-1357 26 14 and and CCONJ dti-1357 26 15 macrolides macrolide NOUN dti-1357 26 16 because because SCONJ dti-1357 26 17 of of ADP dti-1357 26 18 their their PRON dti-1357 26 19 lack lack NOUN dti-1357 26 20 of of ADP dti-1357 26 21 cell cell NOUN dti-1357 26 22 wall wall NOUN dti-1357 26 23 and and CCONJ dti-1357 26 24 a a DET dti-1357 26 25 mutation mutation NOUN dti-1357 26 26 in in ADP dti-1357 26 27 23s 23s PROPN dti-1357 26 28 rrna rrna PROPN dti-1357 26 29 , , PUNCT dti-1357 26 30 respectively.10 respectively.10 ADP dti-1357 26 31 moreover moreover ADV dti-1357 26 32 , , PUNCT dti-1357 26 33 m. m. NOUN dti-1357 26 34 hominis hominis PROPN dti-1357 26 35 has have AUX dti-1357 26 36 been be AUX dti-1357 26 37 found find VERB dti-1357 26 38 to to PART dti-1357 26 39 carry carry VERB dti-1357 26 40 resistance resistance NOUN dti-1357 26 41 trait trait NOUN dti-1357 26 42 against against ADP dti-1357 26 43 ciprofloxacin ciprofloxacin PROPN dti-1357 26 44 and and CCONJ dti-1357 26 45 ofloxacin.11 ofloxacin.11 NOUN dti-1357 26 46 the the DET dti-1357 26 47 increasing increase VERB dti-1357 26 48 trend trend NOUN dti-1357 26 49 of of ADP dti-1357 26 50 antibiotic antibiotic ADJ dti-1357 26 51 resistance resistance NOUN dti-1357 26 52 demands demand VERB dti-1357 26 53 the the DET dti-1357 26 54 discovery discovery NOUN dti-1357 26 55 of of ADP dti-1357 26 56 alternative alternative ADJ dti-1357 26 57 therapeutic therapeutic ADJ dti-1357 26 58 agents agent NOUN dti-1357 26 59 for for ADP dti-1357 26 60 the the DET dti-1357 26 61 treatment treatment NOUN dti-1357 26 62 of of ADP dti-1357 26 63 infection infection NOUN dti-1357 26 64 caused cause VERB dti-1357 26 65 by by ADP dti-1357 26 66 this this DET dti-1357 26 67 bacterium bacterium NOUN dti-1357 26 68 . . PUNCT dti-1357 27 1 these these DET dti-1357 27 2 issues issue NOUN dti-1357 27 3 require require VERB dti-1357 27 4 the the DET dti-1357 27 5 need need NOUN dti-1357 27 6 for for ADP dti-1357 27 7 exploring explore VERB dti-1357 27 8 new new ADJ dti-1357 27 9 drug drug NOUN dti-1357 27 10 targets target NOUN dti-1357 27 11 in in ADP dti-1357 27 12 this this DET dti-1357 27 13 bacterium bacterium NOUN dti-1357 27 14 , , PUNCT dti-1357 27 15 which which PRON dti-1357 27 16 will will AUX dti-1357 27 17 create create VERB dti-1357 27 18 the the DET dti-1357 27 19 avenue avenue NOUN dti-1357 27 20 for for ADP dti-1357 27 21 new new ADJ dti-1357 27 22 drug drug NOUN dti-1357 27 23 discovery discovery NOUN dti-1357 27 24 or or CCONJ dti-1357 27 25 will will AUX dti-1357 27 26 augment augment VERB dti-1357 27 27 the the DET dti-1357 27 28 sensitivity sensitivity NOUN dti-1357 27 29 of of ADP dti-1357 27 30 the the DET dti-1357 27 31 currently currently ADV dti-1357 27 32 existing exist VERB dti-1357 27 33 antimicrobial antimicrobial ADJ dti-1357 27 34 agents agent NOUN dti-1357 27 35 . . PUNCT dti-1357 28 1 increasing increase VERB dti-1357 28 2 availability availability NOUN dti-1357 28 3 of of ADP dti-1357 28 4 related related ADJ dti-1357 28 5 genomics genomic NOUN dti-1357 28 6 , , PUNCT dti-1357 28 7 proteomics proteomic NOUN dti-1357 28 8 , , PUNCT dti-1357 28 9 metabolomics metabolomic NOUN dti-1357 28 10 , , PUNCT dti-1357 28 11 and and CCONJ dti-1357 28 12 many many ADJ dti-1357 28 13 other other ADJ dti-1357 28 14 omics omic NOUN dti-1357 28 15 data datum NOUN dti-1357 28 16 of of ADP dti-1357 28 17 the the DET dti-1357 28 18 infectious infectious ADJ dti-1357 28 19 agents agent NOUN dti-1357 28 20 and and CCONJ dti-1357 28 21 information information NOUN dti-1357 28 22 about about ADP dti-1357 28 23 molecules molecule NOUN dti-1357 28 24 that that PRON dti-1357 28 25 can can AUX dti-1357 28 26 alter alter VERB dti-1357 28 27 the the DET dti-1357 28 28 capability capability NOUN dti-1357 28 29 of of ADP dti-1357 28 30 survival survival NOUN dti-1357 28 31 of of ADP dti-1357 28 32 the the DET dti-1357 28 33 infectious infectious ADJ dti-1357 28 34 organism organism NOUN dti-1357 28 35 have have AUX dti-1357 28 36 facilitated facilitate VERB dti-1357 28 37 the the DET dti-1357 28 38 search search NOUN dti-1357 28 39 for for ADP dti-1357 28 40 new new ADJ dti-1357 28 41 drugs drug NOUN dti-1357 28 42 or or CCONJ dti-1357 28 43 drug drug NOUN dti-1357 28 44 targets target NOUN dti-1357 28 45 . . PUNCT dti-1357 29 1 as as ADP dti-1357 29 2 the the DET dti-1357 29 3 genome genome NOUN dti-1357 29 4 journal journal NOUN dti-1357 29 5 name name NOUN dti-1357 29 6 : : PUNCT dti-1357 29 7 drug drug NOUN dti-1357 29 8 target target NOUN dti-1357 29 9 insights insight NOUN dti-1357 29 10 journal journal NOUN dti-1357 29 11 type type NOUN dti-1357 29 12 : : PUNCT dti-1357 29 13 original original ADJ dti-1357 29 14 research research NOUN dti-1357 29 15 year year NOUN dti-1357 29 16 : : PUNCT dti-1357 29 17 2014 2014 NUM dti-1357 29 18 volume volume NOUN dti-1357 29 19 : : PUNCT dti-1357 29 20 8 8 NUM dti-1357 29 21 running run VERB dti-1357 29 22 head head NOUN dti-1357 29 23 verso verso NOUN dti-1357 29 24 : : PUNCT dti-1357 29 25 parvege parvege NOUN dti-1357 29 26 et et PROPN dti-1357 29 27 al al PROPN dti-1357 29 28 running run VERB dti-1357 29 29 head head NOUN dti-1357 29 30 recto recto NOUN dti-1357 29 31 : : PUNCT dti-1357 29 32 identification identification NOUN dti-1357 29 33 of of ADP dti-1357 29 34 therapeutic therapeutic ADJ dti-1357 29 35 targets target NOUN dti-1357 29 36 in in ADP dti-1357 29 37 mycoplasma mycoplasma NOUN dti-1357 29 38 hominis hominis X dti-1357 29 39 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1357 29 40 http://www.la-press.com http://www.la-press.com X dti-1357 29 41 http://www.la-press.com http://www.la-press.com X dti-1357 30 1 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1357 31 1 http://dx.doi.org/10.4137/dti.s19728 http://dx.doi.org/10.4137/dti.s19728 PROPN dti-1357 31 2 http://creativecommons.org/licenses/by-nc/3.0/ http://creativecommons.org/licenses/by-nc/3.0/ NOUN dti-1357 31 3 http://creativecommons.org/licenses/by-nc/3.0/ http://creativecommons.org/licenses/by-nc/3.0/ PROPN dti-1357 32 1 mailto:mshahnoor@du.ac.bd mailto:mshahnoor@du.ac.bd PROPN dti-1357 32 2 parvege parvege PROPN dti-1357 32 3 et et PROPN dti-1357 32 4 al al PROPN dti-1357 32 5 52 52 NUM dti-1357 32 6 drug drug NOUN dti-1357 32 7 target target NOUN dti-1357 32 8 insights insight NOUN dti-1357 32 9 2014:8 2014:8 NUM dti-1357 32 10 of of ADP dti-1357 32 11 m. m. NOUN dti-1357 32 12 hominis hominis PROPN dti-1357 32 13 , , PUNCT dti-1357 32 14 the the DET dti-1357 32 15 second second ADJ dti-1357 32 16 smallest small ADJ dti-1357 32 17 genome genome NOUN dti-1357 32 18 among among ADP dti-1357 32 19 the the DET dti-1357 32 20 freeliving freelive VERB dti-1357 32 21 organisms organism NOUN dti-1357 32 22 , , PUNCT dti-1357 32 23 has have AUX dti-1357 32 24 already already ADV dti-1357 32 25 been be AUX dti-1357 32 26 sequenced sequence VERB dti-1357 32 27 , , PUNCT dti-1357 32 28 similar similar ADJ dti-1357 32 29 kind kind NOUN dti-1357 32 30 of of ADP dti-1357 32 31 study study NOUN dti-1357 32 32 can can AUX dti-1357 32 33 also also ADV dti-1357 32 34 be be AUX dti-1357 32 35 possible possible ADJ dti-1357 32 36 for for SCONJ dti-1357 32 37 this this DET dti-1357 32 38 bacterium.12 bacterium.12 NOUN dti-1357 32 39 numerous numerous ADJ dti-1357 32 40 in in ADP dti-1357 32 41 silico silico NOUN dti-1357 32 42 methods method NOUN dti-1357 32 43 have have AUX dti-1357 32 44 already already ADV dti-1357 32 45 been be AUX dti-1357 32 46 developed develop VERB dti-1357 32 47 for for ADP dti-1357 32 48 the the DET dti-1357 32 49 prediction prediction NOUN dti-1357 32 50 of of ADP dti-1357 32 51 potential potential ADJ dti-1357 32 52 drug drug NOUN dti-1357 32 53 targets target NOUN dti-1357 32 54 in in ADP dti-1357 32 55 many many ADJ dti-1357 32 56 bacteria bacteria NOUN dti-1357 32 57 and and CCONJ dti-1357 32 58 fungi.13–16 fungi.13–16 NOUN dti-1357 32 59 these these DET dti-1357 32 60 approaches approach NOUN dti-1357 32 61 predict predict VERB dti-1357 32 62 drug drug NOUN dti-1357 32 63 targets target NOUN dti-1357 32 64 by by ADP dti-1357 32 65 comparing compare VERB dti-1357 32 66 the the DET dti-1357 32 67 proteins protein NOUN dti-1357 32 68 present present ADJ dti-1357 32 69 in in ADP dti-1357 32 70 an an DET dti-1357 32 71 infectious infectious ADJ dti-1357 32 72 agent agent NOUN dti-1357 32 73 to to ADP dti-1357 32 74 those those PRON dti-1357 32 75 present present ADJ dti-1357 32 76 or or CCONJ dti-1357 32 77 absent absent ADJ dti-1357 32 78 in in ADP dti-1357 32 79 the the DET dti-1357 32 80 host host NOUN dti-1357 32 81 . . PUNCT dti-1357 33 1 proteins protein NOUN dti-1357 33 2 that that PRON dti-1357 33 3 are be AUX dti-1357 33 4 unique unique ADJ dti-1357 33 5 to to ADP dti-1357 33 6 the the DET dti-1357 33 7 infectious infectious ADJ dti-1357 33 8 agent agent NOUN dti-1357 33 9 and and CCONJ dti-1357 33 10 essential essential ADJ dti-1357 33 11 for for ADP dti-1357 33 12 its its PRON dti-1357 33 13 survival survival NOUN dti-1357 33 14 can can AUX dti-1357 33 15 be be AUX dti-1357 33 16 potential potential ADJ dti-1357 33 17 therapeutic therapeutic ADJ dti-1357 33 18 targets target NOUN dti-1357 33 19 . . PUNCT dti-1357 34 1 in in ADP dti-1357 34 2 principle principle NOUN dti-1357 34 3 , , PUNCT dti-1357 34 4 any any DET dti-1357 34 5 essential essential ADJ dti-1357 34 6 protein protein NOUN dti-1357 34 7 present present ADJ dti-1357 34 8 in in ADP dti-1357 34 9 the the DET dti-1357 34 10 organism organism NOUN dti-1357 34 11 can can AUX dti-1357 34 12 be be AUX dti-1357 34 13 targeted target VERB dti-1357 34 14 to to PART dti-1357 34 15 control control VERB dti-1357 34 16 the the DET dti-1357 34 17 growth growth NOUN dti-1357 34 18 of of ADP dti-1357 34 19 that that DET dti-1357 34 20 organism.17 organism.17 PROPN dti-1357 34 21 in in ADP dti-1357 34 22 the the DET dti-1357 34 23 present present ADJ dti-1357 34 24 study study NOUN dti-1357 34 25 , , PUNCT dti-1357 34 26 we we PRON dti-1357 34 27 performed perform VERB dti-1357 34 28 genomics genomics NOUN dti-1357 34 29 , , PUNCT dti-1357 34 30 proteomics proteomic NOUN dti-1357 34 31 , , PUNCT dti-1357 34 32 and and CCONJ dti-1357 34 33 metabolic metabolic NOUN dti-1357 34 34 pathway pathway NOUN dti-1357 34 35 analysis analysis NOUN dti-1357 34 36 of of ADP dti-1357 34 37 m. m. NOUN dti-1357 34 38 hominis homini NOUN dti-1357 34 39 with with ADP dti-1357 34 40 an an DET dti-1357 34 41 aim aim NOUN dti-1357 34 42 of of ADP dti-1357 34 43 identifying identify VERB dti-1357 34 44 new new ADJ dti-1357 34 45 drug drug NOUN dti-1357 34 46 targets target NOUN dti-1357 34 47 . . PUNCT dti-1357 35 1 this this DET dti-1357 35 2 study study NOUN dti-1357 35 3 identified identify VERB dti-1357 35 4 several several ADJ dti-1357 35 5 drug drug NOUN dti-1357 35 6 targets target NOUN dti-1357 35 7 and and CCONJ dti-1357 35 8 available available ADJ dti-1357 35 9 inhibitors inhibitor NOUN dti-1357 35 10 for for ADP dti-1357 35 11 those those DET dti-1357 35 12 targets target NOUN dti-1357 35 13 . . PUNCT dti-1357 36 1 we we PRON dti-1357 36 2 expect expect VERB dti-1357 36 3 that that SCONJ dti-1357 36 4 present present ADJ dti-1357 36 5 findings finding NOUN dti-1357 36 6 will will AUX dti-1357 36 7 not not PART dti-1357 36 8 only only ADV dti-1357 36 9 extend extend VERB dti-1357 36 10 our our PRON dti-1357 36 11 understanding understanding NOUN dti-1357 36 12 of of ADP dti-1357 36 13 the the DET dti-1357 36 14 molecular molecular ADJ dti-1357 36 15 pathogenesis pathogenesis NOUN dti-1357 36 16 of of ADP dti-1357 36 17 m. m. NOUN dti-1357 36 18 hominis hominis NOUN dti-1357 36 19 , , PUNCT dti-1357 36 20 but but CCONJ dti-1357 36 21 also also ADV dti-1357 36 22 open open VERB dti-1357 36 23 a a DET dti-1357 36 24 new new ADJ dti-1357 36 25 window window NOUN dti-1357 36 26 to to PART dti-1357 36 27 develop develop VERB dti-1357 36 28 novel novel ADJ dti-1357 36 29 therapeutic therapeutic ADJ dti-1357 36 30 agents agent NOUN dti-1357 36 31 against against ADP dti-1357 36 32 this this DET dti-1357 36 33 deadly deadly ADJ dti-1357 36 34 pathogen pathogen NOUN dti-1357 36 35 . . PUNCT dti-1357 37 1 methods method NOUN dti-1357 37 2 identification identification NOUN dti-1357 37 3 of of ADP dti-1357 37 4 pathogen pathogen NOUN dti-1357 37 5 and and CCONJ dti-1357 37 6 host host NOUN dti-1357 37 7 metabolic metabolic NOUN dti-1357 37 8 pathways pathway NOUN dti-1357 37 9 . . PUNCT dti-1357 38 1 consideration consideration NOUN dti-1357 38 2 of of ADP dti-1357 38 3 safety safety NOUN dti-1357 38 4 is be AUX dti-1357 38 5 the the DET dti-1357 38 6 prime prime ADJ dti-1357 38 7 issue issue NOUN dti-1357 38 8 for for ADP dti-1357 38 9 the the DET dti-1357 38 10 development development NOUN dti-1357 38 11 of of ADP dti-1357 38 12 any any DET dti-1357 38 13 therapeutic therapeutic ADJ dti-1357 38 14 agent agent NOUN dti-1357 38 15 . . PUNCT dti-1357 39 1 if if SCONJ dti-1357 39 2 the the DET dti-1357 39 3 therapeutic therapeutic ADJ dti-1357 39 4 agent agent NOUN dti-1357 39 5 is be AUX dti-1357 39 6 not not PART dti-1357 39 7 safe safe ADJ dti-1357 39 8 for for ADP dti-1357 39 9 the the DET dti-1357 39 10 host host NOUN dti-1357 39 11 , , PUNCT dti-1357 39 12 it it PRON dti-1357 39 13 will will AUX dti-1357 39 14 never never ADV dti-1357 39 15 get get VERB dti-1357 39 16 regulatory regulatory ADJ dti-1357 39 17 approval approval NOUN dti-1357 39 18 . . PUNCT dti-1357 40 1 although although SCONJ dti-1357 40 2 the the DET dti-1357 40 3 overall overall ADJ dti-1357 40 4 similarity similarity NOUN dti-1357 40 5 between between ADP dti-1357 40 6 eukaryotic eukaryotic ADJ dti-1357 40 7 and and CCONJ dti-1357 40 8 prokaryotic prokaryotic ADJ dti-1357 40 9 cell cell NOUN dti-1357 40 10 is be AUX dti-1357 40 11 very very ADV dti-1357 40 12 limited limited ADJ dti-1357 40 13 , , PUNCT dti-1357 40 14 the the DET dti-1357 40 15 similarity similarity NOUN dti-1357 40 16 in in ADP dti-1357 40 17 the the DET dti-1357 40 18 coding code VERB dti-1357 40 19 region region NOUN dti-1357 40 20 of of ADP dti-1357 40 21 a a DET dti-1357 40 22 particular particular ADJ dti-1357 40 23 gene gene NOUN dti-1357 40 24 or or CCONJ dti-1357 40 25 functional functional ADJ dti-1357 40 26 domain domain NOUN dti-1357 40 27 of of ADP dti-1357 40 28 any any DET dti-1357 40 29 protein protein NOUN dti-1357 40 30 may may AUX dti-1357 40 31 result result VERB dti-1357 40 32 in in ADP dti-1357 40 33 crossreactivity crossreactivity NOUN dti-1357 40 34 of of ADP dti-1357 40 35 a a DET dti-1357 40 36 therapeutic therapeutic ADJ dti-1357 40 37 agent agent NOUN dti-1357 40 38 against against ADP dti-1357 40 39 the the DET dti-1357 40 40 host host NOUN dti-1357 40 41 . . PUNCT dti-1357 41 1 in in ADP dti-1357 41 2 addition addition NOUN dti-1357 41 3 , , PUNCT dti-1357 41 4 if if SCONJ dti-1357 41 5 a a DET dti-1357 41 6 drug drug NOUN dti-1357 41 7 inhibits inhibit VERB dti-1357 41 8 any any DET dti-1357 41 9 essential essential ADJ dti-1357 41 10 protein protein NOUN dti-1357 41 11 of of ADP dti-1357 41 12 the the DET dti-1357 41 13 host host NOUN dti-1357 41 14 , , PUNCT dti-1357 41 15 it it PRON dti-1357 41 16 might might AUX dti-1357 41 17 produce produce VERB dti-1357 41 18 severe severe ADJ dti-1357 41 19 side side NOUN dti-1357 41 20 effects effect NOUN dti-1357 41 21 to to ADP dti-1357 41 22 the the DET dti-1357 41 23 host host NOUN dti-1357 41 24 species specie NOUN dti-1357 41 25 . . PUNCT dti-1357 42 1 therefore therefore ADV dti-1357 42 2 , , PUNCT dti-1357 42 3 the the DET dti-1357 42 4 starting starting NOUN dti-1357 42 5 point point NOUN dti-1357 42 6 of of ADP dti-1357 42 7 this this DET dti-1357 42 8 study study NOUN dti-1357 42 9 was be AUX dti-1357 42 10 to to PART dti-1357 42 11 compare compare VERB dti-1357 42 12 the the DET dti-1357 42 13 metabolic metabolic NOUN dti-1357 42 14 pathways pathway NOUN dti-1357 42 15 of of ADP dti-1357 42 16 the the DET dti-1357 42 17 pathogen pathogen NOUN dti-1357 42 18 and and CCONJ dti-1357 42 19 the the DET dti-1357 42 20 host host NOUN dti-1357 42 21 species specie NOUN dti-1357 42 22 . . PUNCT dti-1357 43 1 information information NOUN dti-1357 43 2 of of ADP dti-1357 43 3 metabolic metabolic NOUN dti-1357 43 4 pathways pathway NOUN dti-1357 43 5 was be AUX dti-1357 43 6 extracted extract VERB dti-1357 43 7 from from ADP dti-1357 43 8 the the DET dti-1357 43 9 kyoto kyoto PROPN dti-1357 43 10 encyclopedia encyclopedia NOUN dti-1357 43 11 of of ADP dti-1357 43 12 genes gene NOUN dti-1357 43 13 and and CCONJ dti-1357 43 14 genomes genome NOUN dti-1357 43 15 ( ( PUNCT dti-1357 43 16 kegg kegg NOUN dti-1357 43 17 ) ) PUNCT dti-1357 43 18 pathway pathway NOUN dti-1357 43 19 database.18,19 database.18,19 PROPN dti-1357 43 20 metabolic metabolic PROPN dti-1357 43 21 pathways pathway NOUN dti-1357 43 22 and and CCONJ dti-1357 43 23 respective respective ADJ dti-1357 43 24 identification identification NOUN dti-1357 43 25 numbers number NOUN dti-1357 43 26 of of ADP dti-1357 43 27 m. m. NOUN dti-1357 43 28 hominis hominis PROPN dti-1357 43 29 and and CCONJ dti-1357 43 30 h. h. PROPN dti-1357 43 31 sapiens sapiens PROPN dti-1357 43 32 were be AUX dti-1357 43 33 retrieved retrieve VERB dti-1357 43 34 from from ADP dti-1357 43 35 the the DET dti-1357 43 36 ncbi ncbi PROPN dti-1357 43 37 database database NOUN dti-1357 43 38 . . PUNCT dti-1357 44 1 subsequently subsequently ADV dti-1357 44 2 , , PUNCT dti-1357 44 3 a a DET dti-1357 44 4 manual manual ADJ dti-1357 44 5 comparison comparison NOUN dti-1357 44 6 was be AUX dti-1357 44 7 made make VERB dti-1357 44 8 and and CCONJ dti-1357 44 9 pathways pathway NOUN dti-1357 44 10 that that PRON dti-1357 44 11 appeared appear VERB dti-1357 44 12 only only ADV dti-1357 44 13 in in ADP dti-1357 44 14 m. m. NOUN dti-1357 44 15 hominis hominis PROPN dti-1357 44 16 but but CCONJ dti-1357 44 17 not not PART dti-1357 44 18 in in ADP dti-1357 44 19 humans human NOUN dti-1357 44 20 were be AUX dti-1357 44 21 selected select VERB dti-1357 44 22 as as ADP dti-1357 44 23 unique unique ADJ dti-1357 44 24 , , PUNCT dti-1357 44 25 and and CCONJ dti-1357 44 26 the the DET dti-1357 44 27 remaining remain VERB dti-1357 44 28 pathways pathway NOUN dti-1357 44 29 of of ADP dti-1357 44 30 the the DET dti-1357 44 31 pathogen pathogen NOUN dti-1357 44 32 were be AUX dti-1357 44 33 categorized categorize VERB dti-1357 44 34 as as ADP dti-1357 44 35 common common ADJ dti-1357 44 36 pathways pathway NOUN dti-1357 44 37 . . PUNCT dti-1357 45 1 proteins protein NOUN dti-1357 45 2 were be AUX dti-1357 45 3 identified identify VERB dti-1357 45 4 from from ADP dti-1357 45 5 the the DET dti-1357 45 6 unique unique ADJ dti-1357 45 7 and and CCONJ dti-1357 45 8 common common ADJ dti-1357 45 9 pathways pathway NOUN dti-1357 45 10 and and CCONJ dti-1357 45 11 the the DET dti-1357 45 12 corresponding corresponding ADJ dti-1357 45 13 amino amino ADJ dti-1357 45 14 acid acid NOUN dti-1357 45 15 sequences sequence NOUN dti-1357 45 16 were be AUX dti-1357 45 17 downloaded download VERB dti-1357 45 18 from from ADP dti-1357 45 19 the the DET dti-1357 45 20 ncbi ncbi PROPN dti-1357 45 21 database database NOUN dti-1357 45 22 . . PUNCT dti-1357 46 1 screening screen VERB dti-1357 46 2 of of ADP dti-1357 46 3 essential essential ADJ dti-1357 46 4 genes gene NOUN dti-1357 46 5 . . PUNCT dti-1357 47 1 genes gene NOUN dti-1357 47 2 that that PRON dti-1357 47 3 are be AUX dti-1357 47 4 indispensable indispensable ADJ dti-1357 47 5 to to ADP dti-1357 47 6 supporting support VERB dti-1357 47 7 cellular cellular ADJ dti-1357 47 8 life life NOUN dti-1357 47 9 are be AUX dti-1357 47 10 called call VERB dti-1357 47 11 essential essential ADJ dti-1357 47 12 genes gene NOUN dti-1357 47 13 . . PUNCT dti-1357 48 1 database database NOUN dti-1357 48 2 of of ADP dti-1357 48 3 essential essential ADJ dti-1357 48 4 genes gene NOUN dti-1357 48 5 ( ( PUNCT dti-1357 48 6 deg deg NOUN dti-1357 48 7 ) ) PUNCT dti-1357 48 8 includes include VERB dti-1357 48 9 all all PRON dti-1357 48 10 of of ADP dti-1357 48 11 the the DET dti-1357 48 12 essential essential ADJ dti-1357 48 13 genes gene NOUN dti-1357 48 14 that that PRON dti-1357 48 15 are be AUX dti-1357 48 16 currently currently ADV dti-1357 48 17 available available ADJ dti-1357 48 18 . . PUNCT dti-1357 49 1 to to PART dti-1357 49 2 identify identify VERB dti-1357 49 3 essential essential ADJ dti-1357 49 4 genes gene NOUN dti-1357 49 5 of of ADP dti-1357 49 6 m. m. NOUN dti-1357 49 7 hominis hominis NOUN dti-1357 49 8 , , PUNCT dti-1357 49 9 proteins protein NOUN dti-1357 49 10 of of ADP dti-1357 49 11 unique unique ADJ dti-1357 49 12 and and CCONJ dti-1357 49 13 common common ADJ dti-1357 49 14 pathways pathway NOUN dti-1357 49 15 were be AUX dti-1357 49 16 subjected subject VERB dti-1357 49 17 to to PART dti-1357 49 18 blastp blastp VERB dti-1357 49 19 against against ADP dti-1357 49 20 deg deg PROPN dti-1357 49 21 with with ADP dti-1357 49 22 an an DET dti-1357 49 23 e e NOUN dti-1357 49 24 - - NOUN dti-1357 49 25 value value NOUN dti-1357 49 26 cut cut NOUN dti-1357 49 27 - - PUNCT dti-1357 49 28 off off NOUN dti-1357 49 29 of of ADP dti-1357 49 30 10 10 NUM dti-1357 49 31 - - SYM dti-1357 49 32 10 10 NUM dti-1357 49 33 and and CCONJ dti-1357 49 34 with with ADP dti-1357 49 35 a a DET dti-1357 49 36 minimum minimum ADJ dti-1357 49 37 bit bit NOUN dti-1357 49 38 score score NOUN dti-1357 49 39 of of ADP dti-1357 49 40 100.20 100.20 NUM dti-1357 49 41 identification identification NOUN dti-1357 49 42 of of ADP dti-1357 49 43 non non ADJ dti-1357 49 44 - - ADJ dti-1357 49 45 host host ADJ dti-1357 49 46 essential essential ADJ dti-1357 49 47 proteins protein NOUN dti-1357 49 48 . . PUNCT dti-1357 50 1 after after ADP dti-1357 50 2 the the DET dti-1357 50 3 identification identification NOUN dti-1357 50 4 of of ADP dti-1357 50 5 essential essential ADJ dti-1357 50 6 proteins protein NOUN dti-1357 50 7 , , PUNCT dti-1357 50 8 they they PRON dti-1357 50 9 were be AUX dti-1357 50 10 compared compare VERB dti-1357 50 11 with with ADP dti-1357 50 12 the the DET dti-1357 50 13 human human ADJ dti-1357 50 14 non non ADJ dti-1357 50 15 - - ADJ dti-1357 50 16 redundant redundant ADJ dti-1357 50 17 protein protein NOUN dti-1357 50 18 sequence sequence NOUN dti-1357 50 19 database database NOUN dti-1357 50 20 ( ( PUNCT dti-1357 50 21 nr nr X dti-1357 50 22 ) ) PUNCT dti-1357 50 23 to to PART dti-1357 50 24 identify identify VERB dti-1357 50 25 non non ADJ dti-1357 50 26 - - ADJ dti-1357 50 27 host host ADJ dti-1357 50 28 proteins protein NOUN dti-1357 50 29 of of ADP dti-1357 50 30 m. m. NOUN dti-1357 50 31 hominis hominis PROPN dti-1357 50 32 . . PUNCT dti-1357 51 1 a a DET dti-1357 51 2 blastp blastp NOUN dti-1357 51 3 analysis analysis NOUN dti-1357 51 4 was be AUX dti-1357 51 5 performed perform VERB dti-1357 51 6 and and CCONJ dti-1357 51 7 proteins protein NOUN dti-1357 51 8 without without ADP dti-1357 51 9 hits hit NOUN dti-1357 51 10 below below ADP dti-1357 51 11 the the DET dti-1357 51 12 threshold threshold NOUN dti-1357 51 13 e e NOUN dti-1357 51 14 - - NOUN dti-1357 51 15 value value NOUN dti-1357 51 16 of of ADP dti-1357 51 17 0.005 0.005 NUM dti-1357 51 18 and and CCONJ dti-1357 51 19 35 35 NOUN dti-1357 51 20 % % NOUN dti-1357 51 21 identity identity NOUN dti-1357 51 22 were be AUX dti-1357 51 23 picked pick VERB dti-1357 51 24 out out ADP dti-1357 51 25 as as ADP dti-1357 51 26 nonhost nonhost ADJ dti-1357 51 27 essential essential ADJ dti-1357 51 28 proteins.21 proteins.21 ADJ dti-1357 51 29 molecular molecular ADJ dti-1357 51 30 weight weight NOUN dti-1357 51 31 determination determination NOUN dti-1357 51 32 and and CCONJ dti-1357 51 33 protein protein NOUN dti-1357 51 34 3 3 NUM dti-1357 51 35 - - SYM dti-1357 51 36 d d NOUN dti-1357 51 37 structure structure NOUN dti-1357 51 38 identification identification NOUN dti-1357 51 39 . . PUNCT dti-1357 52 1 molecular molecular ADJ dti-1357 52 2 weight weight NOUN dti-1357 52 3 ( ( PUNCT dti-1357 52 4 mw mw PROPN dti-1357 52 5 ) ) PUNCT dti-1357 52 6 of of ADP dti-1357 52 7 each each PRON dti-1357 52 8 of of ADP dti-1357 52 9 the the DET dti-1357 52 10 potential potential ADJ dti-1357 52 11 targets target NOUN dti-1357 52 12 was be AUX dti-1357 52 13 determined determine VERB dti-1357 52 14 using use VERB dti-1357 52 15 online online ADJ dti-1357 52 16 tools tool NOUN dti-1357 52 17 followed follow VERB dti-1357 52 18 by by ADP dti-1357 52 19 confirmation confirmation NOUN dti-1357 52 20 with with ADP dti-1357 52 21 the the DET dti-1357 52 22 available available ADJ dti-1357 52 23 literature literature NOUN dti-1357 52 24 . . PUNCT dti-1357 53 1 previous previous ADJ dti-1357 53 2 literature literature PROPN dti-1357 53 3 suggested suggest VERB dti-1357 53 4 that that SCONJ dti-1357 53 5 smaller small ADJ dti-1357 53 6 proteins protein NOUN dti-1357 53 7 are be AUX dti-1357 53 8 suitable suitable ADJ dti-1357 53 9 targets target NOUN dti-1357 53 10 for for ADP dti-1357 53 11 drug drug NOUN dti-1357 53 12 development development NOUN dti-1357 53 13 because because SCONJ dti-1357 53 14 they they PRON dti-1357 53 15 are be AUX dti-1357 53 16 more more ADV dti-1357 53 17 soluble soluble ADJ dti-1357 53 18 and and CCONJ dti-1357 53 19 easier easy ADJ dti-1357 53 20 to to PART dti-1357 53 21 purify purify VERB dti-1357 53 22 in in ADP dti-1357 53 23 comparison comparison NOUN dti-1357 53 24 with with ADP dti-1357 53 25 large large ADJ dti-1357 53 26 proteins.22 proteins.22 ADJ dti-1357 53 27 proteins protein NOUN dti-1357 53 28 having have VERB dti-1357 53 29 mw mw VERB dti-1357 53 30 larger large ADJ dti-1357 53 31 than than SCONJ dti-1357 53 32 110 110 NUM dti-1357 53 33     SPACE dti-1357 53 34 kda kda NOUN dti-1357 53 35 were be AUX dti-1357 53 36 excluded exclude VERB dti-1357 53 37 , , PUNCT dti-1357 53 38 and and CCONJ dti-1357 53 39 the the DET dti-1357 53 40 resultant resultant NOUN dti-1357 53 41 list list NOUN dti-1357 53 42 of of ADP dti-1357 53 43 proteins protein NOUN dti-1357 53 44 was be AUX dti-1357 53 45 enlisted enlist VERB dti-1357 53 46 as as ADP dti-1357 53 47 sigma sigma NOUN dti-1357 53 48 ( ( PUNCT dti-1357 53 49 ∑ ∑ PROPN dti-1357 53 50 ) ) PUNCT dti-1357 53 51 and and CCONJ dti-1357 53 52 was be AUX dti-1357 53 53 used use VERB dti-1357 53 54 for for ADP dti-1357 53 55 qualitative qualitative ADJ dti-1357 53 56 analyses analysis NOUN dti-1357 53 57 . . PUNCT dti-1357 54 1 the the DET dti-1357 54 2 3 3 NUM dti-1357 54 3 - - PUNCT dti-1357 54 4 d d NOUN dti-1357 54 5 structure structure NOUN dti-1357 54 6 was be AUX dti-1357 54 7 scanned scan VERB dti-1357 54 8 by by ADP dti-1357 54 9 searching search VERB dti-1357 54 10 the the DET dti-1357 54 11 protein protein NOUN dti-1357 54 12 data datum NOUN dti-1357 54 13 bank bank NOUN dti-1357 54 14 ( ( PUNCT dti-1357 54 15 pdb)23,24 pdb)23,24 NOUN dti-1357 54 16 and and CCONJ dti-1357 54 17 modbase25,26 modbase25,26 NOUN dti-1357 54 18 databases database NOUN dti-1357 54 19 . . PUNCT dti-1357 55 1 pdb pdb PROPN dti-1357 55 2 is be AUX dti-1357 55 3 the the DET dti-1357 55 4 worldwide worldwide ADJ dti-1357 55 5 repository repository NOUN dti-1357 55 6 where where SCONJ dti-1357 55 7 experimentally experimentally ADV dti-1357 55 8 determined determine VERB dti-1357 55 9 structures structure NOUN dti-1357 55 10 of of ADP dti-1357 55 11 proteins protein NOUN dti-1357 55 12 , , PUNCT dti-1357 55 13 nucleic nucleic ADJ dti-1357 55 14 acids acid NOUN dti-1357 55 15 , , PUNCT dti-1357 55 16 and and CCONJ dti-1357 55 17 complex complex ADJ dti-1357 55 18 biomolecular biomolecular ADJ dti-1357 55 19 assemblies assembly NOUN dti-1357 55 20 are be AUX dti-1357 55 21 deposited deposit VERB dti-1357 55 22 . . PUNCT dti-1357 56 1 these these DET dti-1357 56 2 structures structure NOUN dti-1357 56 3 are be AUX dti-1357 56 4 curated curate VERB dti-1357 56 5 and and CCONJ dti-1357 56 6 annotated annotate VERB dti-1357 56 7 following follow VERB dti-1357 56 8 the the DET dti-1357 56 9 standards standard NOUN dti-1357 56 10 set set VERB dti-1357 56 11 by by ADP dti-1357 56 12 pdb pdb PROPN dti-1357 56 13 . . PUNCT dti-1357 57 1 on on ADP dti-1357 57 2 the the DET dti-1357 57 3 other other ADJ dti-1357 57 4 hand hand NOUN dti-1357 57 5 , , PUNCT dti-1357 57 6 modbase modbase PROPN dti-1357 57 7 is be AUX dti-1357 57 8 a a DET dti-1357 57 9 database database NOUN dti-1357 57 10 of of ADP dti-1357 57 11 protein protein NOUN dti-1357 57 12 structures structure NOUN dti-1357 57 13 that that PRON dti-1357 57 14 have have AUX dti-1357 57 15 been be AUX dti-1357 57 16 developed develop VERB dti-1357 57 17 by by ADP dti-1357 57 18 computational computational ADJ dti-1357 57 19 approaches approach NOUN dti-1357 57 20 and and CCONJ dti-1357 57 21 validated validate VERB dti-1357 57 22 by by ADP dti-1357 57 23 statistically statistically ADV dti-1357 57 24 significant significant ADJ dti-1357 57 25 sequence sequence NOUN dti-1357 57 26 alignment alignment NOUN dti-1357 57 27 and and CCONJ dti-1357 57 28 model model NOUN dti-1357 57 29 assessment assessment NOUN dti-1357 57 30 . . PUNCT dti-1357 58 1 qualitative qualitative ADJ dti-1357 58 2 characterization characterization NOUN dti-1357 58 3 of of ADP dti-1357 58 4 the the DET dti-1357 58 5 ∑ ∑ PROPN dti-1357 58 6 list list NOUN dti-1357 58 7 . . PUNCT dti-1357 59 1 different different ADJ dti-1357 59 2 structural structural ADJ dti-1357 59 3 and and CCONJ dti-1357 59 4 molecular molecular ADJ dti-1357 59 5 criteria criterion NOUN dti-1357 59 6 that that PRON dti-1357 59 7 facilitate facilitate VERB dti-1357 59 8 prioritizing prioritize VERB dti-1357 59 9 therapeutic therapeutic ADJ dti-1357 59 10 targets target NOUN dti-1357 59 11 in in ADP dti-1357 59 12 pathogens pathogen NOUN dti-1357 59 13 were be AUX dti-1357 59 14 assessed assess VERB dti-1357 59 15 for for SCONJ dti-1357 59 16 the the DET dti-1357 59 17 ∑ ∑ PUNCT dti-1357 59 18 list.27 list.27 PROPN dti-1357 59 19 this this PRON dti-1357 59 20 involved involve VERB dti-1357 59 21 the the DET dti-1357 59 22 prediction prediction NOUN dti-1357 59 23 of of ADP dti-1357 59 24 subcellular subcellular ADJ dti-1357 59 25 location location NOUN dti-1357 59 26 , , PUNCT dti-1357 59 27 functional functional ADJ dti-1357 59 28 analysis analysis NOUN dti-1357 59 29 , , PUNCT dti-1357 59 30 protein protein NOUN dti-1357 59 31 network network NOUN dti-1357 59 32 analysis analysis NOUN dti-1357 59 33 , , PUNCT dti-1357 59 34 broad broad ADJ dti-1357 59 35 spectrum spectrum NOUN dti-1357 59 36 analysis analysis NOUN dti-1357 59 37 , , PUNCT dti-1357 59 38 and and CCONJ dti-1357 59 39 druggability druggability NOUN dti-1357 59 40 analysis analysis NOUN dti-1357 59 41 of of ADP dti-1357 59 42 the the DET dti-1357 59 43 ∑ ∑ PROPN dti-1357 59 44 list list NOUN dti-1357 59 45 . . PUNCT dti-1357 60 1 subcellular subcellular ADJ dti-1357 60 2 localization localization NOUN dti-1357 60 3 analysis analysis NOUN dti-1357 60 4 . . PUNCT dti-1357 61 1 subcellular subcellular ADJ dti-1357 61 2 localization localization NOUN dti-1357 61 3 analysis analysis NOUN dti-1357 61 4 of of ADP dti-1357 61 5 a a DET dti-1357 61 6 protein protein NOUN dti-1357 61 7 reveals reveal VERB dti-1357 61 8 whether whether SCONJ dti-1357 61 9 that that DET dti-1357 61 10 protein protein NOUN dti-1357 61 11 is be AUX dti-1357 61 12 suitable suitable ADJ dti-1357 61 13 as as ADP dti-1357 61 14 a a DET dti-1357 61 15 drug drug NOUN dti-1357 61 16 or or CCONJ dti-1357 61 17 a a DET dti-1357 61 18 vaccine vaccine NOUN dti-1357 61 19 target target NOUN dti-1357 61 20 . . PUNCT dti-1357 62 1 cytoplasmic cytoplasmic ADJ dti-1357 62 2 proteins protein NOUN dti-1357 62 3 can can AUX dti-1357 62 4 work work VERB dti-1357 62 5 better well ADV dti-1357 62 6 as as ADP dti-1357 62 7 drug drug NOUN dti-1357 62 8 targets target NOUN dti-1357 62 9 while while SCONJ dti-1357 62 10 surface surface NOUN dti-1357 62 11 membrane membrane NOUN dti-1357 62 12 proteins protein NOUN dti-1357 62 13 can can AUX dti-1357 62 14 be be AUX dti-1357 62 15 used use VERB dti-1357 62 16 as as ADP dti-1357 62 17 targets target NOUN dti-1357 62 18 for for ADP dti-1357 62 19 vaccine vaccine NOUN dti-1357 62 20 development.28 development.28 NOUN dti-1357 62 21 psortb psortb VERB dti-1357 62 22 v3.0 v3.0 DET dti-1357 62 23 server server NOUN dti-1357 62 24 was be AUX dti-1357 62 25 used use VERB dti-1357 62 26 to to PART dti-1357 62 27 predict predict VERB dti-1357 62 28 the the DET dti-1357 62 29 subcellular subcellular ADJ dti-1357 62 30 localization localization NOUN dti-1357 62 31 of of ADP dti-1357 62 32 the the DET dti-1357 62 33 proteins,29 proteins,29 NOUN dti-1357 62 34 and and CCONJ dti-1357 62 35 the the DET dti-1357 62 36 results result NOUN dti-1357 62 37 were be AUX dti-1357 62 38 further far ADV dti-1357 62 39 crosschecked crosschecke VERB dti-1357 62 40 with with ADP dti-1357 62 41 predictions prediction NOUN dti-1357 62 42 obtained obtain VERB dti-1357 62 43 from from ADP dti-1357 62 44 cello cello NOUN dti-1357 62 45 v.2.5,30,31 v.2.5,30,31 NOUN dti-1357 62 46 topcons,32 topcons,32 VERB dti-1357 62 47 and and CCONJ dti-1357 62 48 tmhmm.33 tmhmm.33 PROPN dti-1357 62 49 psortb psortb NOUN dti-1357 62 50 uses use VERB dti-1357 62 51 11692 11692 NUM dti-1357 62 52 proteins protein NOUN dti-1357 62 53 of of ADP dti-1357 62 54 known know VERB dti-1357 62 55 localization localization NOUN dti-1357 62 56 from from ADP dti-1357 62 57 bacteria bacteria NOUN dti-1357 62 58 and and CCONJ dti-1357 62 59 archaea archaea NOUN dti-1357 62 60 as as ADP dti-1357 62 61 a a DET dti-1357 62 62 training training NOUN dti-1357 62 63 set set VERB dti-1357 62 64 to to PART dti-1357 62 65 sort sort VERB dti-1357 62 66 out out ADP dti-1357 62 67 the the DET dti-1357 62 68 location location NOUN dti-1357 62 69 of of ADP dti-1357 62 70 a a DET dti-1357 62 71 given give VERB dti-1357 62 72 protein protein NOUN dti-1357 62 73 . . PUNCT dti-1357 63 1 cello cello PROPN dti-1357 63 2 contains contain VERB dti-1357 63 3 9033 9033 NUM dti-1357 63 4 protein protein NOUN dti-1357 63 5 sequences sequence NOUN dti-1357 63 6 as as ADP dti-1357 63 7 benchmark benchmark NOUN dti-1357 63 8 datasets dataset NOUN dti-1357 63 9 for for ADP dti-1357 63 10 the the DET dti-1357 63 11 prediction prediction NOUN dti-1357 63 12 of of ADP dti-1357 63 13 protein protein NOUN dti-1357 63 14 localization localization NOUN dti-1357 63 15 using use VERB dti-1357 63 16 a a DET dti-1357 63 17 support support NOUN dti-1357 63 18 vector vector NOUN dti-1357 63 19 machine machine NOUN dti-1357 63 20 ( ( PUNCT dti-1357 63 21 svm svm ADJ dti-1357 63 22 ) ) PUNCT dti-1357 63 23 method method NOUN dti-1357 63 24 . . PUNCT dti-1357 64 1 tmhmm tmhmm PROPN dti-1357 64 2 is be AUX dti-1357 64 3 based base VERB dti-1357 64 4 on on ADP dti-1357 64 5 hidden hide VERB dti-1357 64 6 markov markov NOUN dti-1357 64 7 model model NOUN dti-1357 64 8 , , PUNCT dti-1357 64 9 and and CCONJ dti-1357 64 10 experimental experimental ADJ dti-1357 64 11 evidence evidence NOUN dti-1357 64 12 shows show VERB dti-1357 64 13 that that SCONJ dti-1357 64 14 it it PRON dti-1357 64 15 correctly correctly ADV dti-1357 64 16 predicts predict VERB dti-1357 64 17 97–98 97–98 NUM dti-1357 64 18 % % NOUN dti-1357 64 19 of of ADP dti-1357 64 20 the the DET dti-1357 64 21 transmembrane transmembrane NOUN dti-1357 64 22 helices helix NOUN dti-1357 64 23 . . PUNCT dti-1357 65 1 functional functional ADJ dti-1357 65 2 analysis analysis NOUN dti-1357 65 3 . . PUNCT dti-1357 66 1 the the DET dti-1357 66 2 functions function NOUN dti-1357 66 3 of of ADP dti-1357 66 4 the the DET dti-1357 66 5 hypothetical hypothetical ADJ dti-1357 66 6 proteins protein NOUN dti-1357 66 7 in in ADP dti-1357 66 8 the the DET dti-1357 66 9 ∑ ∑ PROPN dti-1357 66 10 list list NOUN dti-1357 66 11 were be AUX dti-1357 66 12 predicted predict VERB dti-1357 66 13 using use VERB dti-1357 66 14 interpro interpro ADJ dti-1357 66 15 online online ADJ dti-1357 66 16 tool.34 tool.34 ADV dti-1357 66 17 interpro interpro ADJ dti-1357 66 18 classifies classify VERB dti-1357 66 19 hypothetical hypothetical ADJ dti-1357 66 20 proteins protein NOUN dti-1357 66 21 into into ADP dti-1357 66 22 families family NOUN dti-1357 66 23 and and CCONJ dti-1357 66 24 predicts predict VERB dti-1357 66 25 domains domain NOUN dti-1357 66 26 and and CCONJ dti-1357 66 27 important important ADJ dti-1357 66 28 sites site NOUN dti-1357 66 29 by by ADP dti-1357 66 30 integrating integrate VERB dti-1357 66 31 various various ADJ dti-1357 66 32 protein protein NOUN dti-1357 66 33 signature signature NOUN dti-1357 66 34 recognition recognition NOUN dti-1357 66 35 methods method NOUN dti-1357 66 36 and and CCONJ dti-1357 66 37 databases database NOUN dti-1357 66 38 . . PUNCT dti-1357 67 1 broad broad ADJ dti-1357 67 2 spectrum spectrum NOUN dti-1357 67 3 analysis analysis NOUN dti-1357 67 4 . . PUNCT dti-1357 68 1 a a DET dti-1357 68 2 blastp blastp NOUN dti-1357 68 3 search search NOUN dti-1357 68 4 against against ADP dti-1357 68 5 a a DET dti-1357 68 6 wide wide ADJ dti-1357 68 7 range range NOUN dti-1357 68 8 of of ADP dti-1357 68 9 pathogenic pathogenic ADJ dti-1357 68 10 bacteria bacteria NOUN dti-1357 68 11 with with ADP dti-1357 68 12 an an DET dti-1357 68 13 expected expect VERB dti-1357 68 14 threshold threshold NOUN dti-1357 68 15 value value NOUN dti-1357 68 16 of of ADP dti-1357 68 17 0.005 0.005 NUM dti-1357 68 18 was be AUX dti-1357 68 19 used use VERB dti-1357 68 20 to to PART dti-1357 68 21 analyze analyze VERB dti-1357 68 22 proteins protein NOUN dti-1357 68 23 in in ADP dti-1357 68 24 the the DET dti-1357 68 25 ∑ ∑ NOUN dti-1357 68 26 list list NOUN dti-1357 68 27 for for ADP dti-1357 68 28 the the DET dti-1357 68 29 identification identification NOUN dti-1357 68 30 of of ADP dti-1357 68 31 broad broad ADJ dti-1357 68 32 spectrum spectrum NOUN dti-1357 68 33 targets target NOUN dti-1357 68 34 . . PUNCT dti-1357 69 1 a a DET dti-1357 69 2 total total NOUN dti-1357 69 3 of of ADP dti-1357 69 4 240 240 NUM dti-1357 69 5 diseasecausing diseasecausing NOUN dti-1357 69 6 bacteria bacteria NOUN dti-1357 69 7 from from ADP dti-1357 69 8 different different ADJ dti-1357 69 9 genus genus NOUN dti-1357 69 10 were be AUX dti-1357 69 11 used use VERB dti-1357 69 12 in in ADP dti-1357 69 13 the the DET dti-1357 69 14 broad broad ADJ dti-1357 69 15 spectrum spectrum NOUN dti-1357 69 16 analysis.35 analysis.35 NOUN dti-1357 69 17 from from ADP dti-1357 69 18 the the DET dti-1357 69 19 homology homology NOUN dti-1357 69 20 analysis analysis NOUN dti-1357 69 21 against against ADP dti-1357 69 22 each each PRON dti-1357 69 23 of of ADP dti-1357 69 24 the the DET dti-1357 69 25 pathogen pathogen NOUN dti-1357 69 26 , , PUNCT dti-1357 69 27 it it PRON dti-1357 69 28 is be AUX dti-1357 69 29 speculated speculate VERB dti-1357 69 30 that that SCONJ dti-1357 69 31 close close ADJ dti-1357 69 32 homologs homolog NOUN dti-1357 69 33 present present ADJ dti-1357 69 34 in in ADP dti-1357 69 35 http://www.la-press.com http://www.la-press.com X dti-1357 69 36 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1357 69 37 identification identification NOUN dti-1357 69 38 of of ADP dti-1357 69 39 therapeutic therapeutic ADJ dti-1357 69 40 targets target NOUN dti-1357 69 41 in in ADP dti-1357 69 42 mycoplasma mycoplasma NOUN dti-1357 69 43 hominis hominis X dti-1357 69 44 53drug 53drug X dti-1357 69 45 target target NOUN dti-1357 69 46 insights insight VERB dti-1357 69 47 2014:8 2014:8 NUM dti-1357 69 48 maximum maximum ADJ dti-1357 69 49 number number NOUN dti-1357 69 50 of of ADP dti-1357 69 51 pathogens pathogen NOUN dti-1357 69 52 are be AUX dti-1357 69 53 better well ADJ dti-1357 69 54 likely likely ADJ dti-1357 69 55 to to PART dti-1357 69 56 be be AUX dti-1357 69 57 promising promise VERB dti-1357 69 58 broad broad ADJ dti-1357 69 59 spectrum spectrum NOUN dti-1357 69 60 targets target NOUN dti-1357 69 61 . . PUNCT dti-1357 70 1 interactome interactome NOUN dti-1357 70 2 analysis analysis NOUN dti-1357 70 3 . . PUNCT dti-1357 71 1 a a DET dti-1357 71 2 network network NOUN dti-1357 71 3 of of ADP dti-1357 71 4 protein protein NOUN dti-1357 71 5 – – PUNCT dti-1357 71 6 protein protein NOUN dti-1357 71 7 interaction interaction NOUN dti-1357 71 8 was be AUX dti-1357 71 9 constructed construct VERB dti-1357 71 10 for for ADP dti-1357 71 11 each each PRON dti-1357 71 12 of of ADP dti-1357 71 13 the the DET dti-1357 71 14 ∑ ∑ ADV dti-1357 71 15 listed list VERB dti-1357 71 16 proteins protein NOUN dti-1357 71 17 using use VERB dti-1357 71 18 string string NOUN dti-1357 71 19 9.1.36,37 9.1.36,37 NUM dti-1357 71 20 string string NOUN dti-1357 71 21 constructs construct NOUN dti-1357 71 22 protein protein NOUN dti-1357 71 23 – – PUNCT dti-1357 71 24 protein protein NOUN dti-1357 71 25 interaction interaction NOUN dti-1357 71 26 networks network NOUN dti-1357 71 27 based base VERB dti-1357 71 28 on on ADP dti-1357 71 29 experimental experimental ADJ dti-1357 71 30 data datum NOUN dti-1357 71 31 , , PUNCT dti-1357 71 32 gene gene NOUN dti-1357 71 33 - - PUNCT dti-1357 71 34 based base VERB dti-1357 71 35 analysis analysis NOUN dti-1357 71 36 ( ( PUNCT dti-1357 71 37 neighborhood neighborhood NOUN dti-1357 71 38 , , PUNCT dti-1357 71 39 gene gene NOUN dti-1357 71 40 fusion fusion NOUN dti-1357 71 41 , , PUNCT dti-1357 71 42 co co NOUN dti-1357 71 43 - - NOUN dti-1357 71 44 occurrence occurrence NOUN dti-1357 71 45 , , PUNCT dti-1357 71 46 and and CCONJ dti-1357 71 47 co co NOUN dti-1357 71 48 - - NOUN dti-1357 71 49 expression expression NOUN dti-1357 71 50 ) ) PUNCT dti-1357 71 51 , , PUNCT dti-1357 71 52 curated curate VERB dti-1357 71 53 pathways pathway NOUN dti-1357 71 54 database database NOUN dti-1357 71 55 , , PUNCT dti-1357 71 56 and and CCONJ dti-1357 71 57 various various ADJ dti-1357 71 58 protein protein NOUN dti-1357 71 59 interactions interaction NOUN dti-1357 71 60 databases database NOUN dti-1357 71 61 . . PUNCT dti-1357 72 1 high high ADJ dti-1357 72 2 confidence confidence NOUN dti-1357 72 3 interactors interactor NOUN dti-1357 72 4 with with ADP dti-1357 72 5 score score NOUN dti-1357 72 6 greater great ADJ dti-1357 72 7 than than ADP dti-1357 72 8 or or CCONJ dti-1357 72 9 equal equal ADJ dti-1357 72 10 to to ADP dti-1357 72 11 0.700 0.700 NUM dti-1357 72 12 alone alone ADV dti-1357 72 13 were be AUX dti-1357 72 14 included include VERB dti-1357 72 15 in in ADP dti-1357 72 16 the the DET dti-1357 72 17 protein protein NOUN dti-1357 72 18 network network NOUN dti-1357 72 19 . . PUNCT dti-1357 73 1 to to PART dti-1357 73 2 minimize minimize VERB dti-1357 73 3 false false ADJ dti-1357 73 4 positives positive NOUN dti-1357 73 5 and and CCONJ dti-1357 73 6 false false ADJ dti-1357 73 7 negatives negative NOUN dti-1357 73 8 , , PUNCT dti-1357 73 9 all all DET dti-1357 73 10 interactors interactor NOUN dti-1357 73 11 with with ADP dti-1357 73 12 low low ADJ dti-1357 73 13 as as ADV dti-1357 73 14 well well ADV dti-1357 73 15 as as ADP dti-1357 73 16 medium medium ADJ dti-1357 73 17 confidence confidence NOUN dti-1357 73 18 scores score NOUN dti-1357 73 19 were be AUX dti-1357 73 20 removed remove VERB dti-1357 73 21 from from ADP dti-1357 73 22 the the DET dti-1357 73 23 network network NOUN dti-1357 73 24 . . PUNCT dti-1357 74 1 druggability druggability NOUN dti-1357 74 2 analysis analysis NOUN dti-1357 74 3 . . PUNCT dti-1357 75 1 to to PART dti-1357 75 2 be be AUX dti-1357 75 3 druggable druggable ADJ dti-1357 75 4 , , PUNCT dti-1357 75 5 a a DET dti-1357 75 6 target target NOUN dti-1357 75 7 must must AUX dti-1357 75 8 have have VERB dti-1357 75 9 the the DET dti-1357 75 10 potency potency NOUN dti-1357 75 11 to to PART dti-1357 75 12 interact interact VERB dti-1357 75 13 with with ADP dti-1357 75 14 drug drug NOUN dti-1357 75 15 or or CCONJ dti-1357 75 16 drug drug NOUN dti-1357 75 17 - - PUNCT dti-1357 75 18 like like ADJ dti-1357 75 19 molecules molecule NOUN dti-1357 75 20 with with ADP dti-1357 75 21 high high ADJ dti-1357 75 22 affinity affinity NOUN dti-1357 75 23 . . PUNCT dti-1357 76 1 in in ADP dti-1357 76 2 this this DET dti-1357 76 3 study study NOUN dti-1357 76 4 , , PUNCT dti-1357 76 5 the the DET dti-1357 76 6 druggability druggability NOUN dti-1357 76 7 potential potential NOUN dti-1357 76 8 of of ADP dti-1357 76 9 each each DET dti-1357 76 10 protein protein NOUN dti-1357 76 11 of of ADP dti-1357 76 12 the the DET dti-1357 76 13 ∑ ∑ PROPN dti-1357 76 14 list list NOUN dti-1357 76 15 was be AUX dti-1357 76 16 assessed assess VERB dti-1357 76 17 by by ADP dti-1357 76 18 drugbank.38 drugbank.38 PROPN dti-1357 76 19 currently currently ADV dti-1357 76 20 , , PUNCT dti-1357 76 21 drugbank drugbank NOUN dti-1357 76 22 is be AUX dti-1357 76 23 a a DET dti-1357 76 24 huge huge ADJ dti-1357 76 25 and and CCONJ dti-1357 76 26 comprehensive comprehensive ADJ dti-1357 76 27 collection collection NOUN dti-1357 76 28 of of ADP dti-1357 76 29 drugs drug NOUN dti-1357 76 30 with with ADP dti-1357 76 31 the the DET dti-1357 76 32 target target NOUN dti-1357 76 33 information information NOUN dti-1357 76 34 . . PUNCT dti-1357 77 1 this this DET dti-1357 77 2 database database NOUN dti-1357 77 3 comprises comprise VERB dti-1357 77 4 6816 6816 NUM dti-1357 77 5 experimental experimental ADJ dti-1357 77 6 and and CCONJ dti-1357 77 7 fda fda PROPN dti-1357 77 8 - - PUNCT dti-1357 77 9 approved approve VERB dti-1357 77 10 drugs drug NOUN dti-1357 77 11 , , PUNCT dti-1357 77 12 4326 4326 NUM dti-1357 77 13 drug drug NOUN dti-1357 77 14 targets target NOUN dti-1357 77 15 , , PUNCT dti-1357 77 16 and and CCONJ dti-1357 77 17 169 169 NUM dti-1357 77 18 drug drug NOUN dti-1357 77 19 enzymes enzyme NOUN dti-1357 77 20 / / SYM dti-1357 77 21 carriers carrier NOUN dti-1357 77 22 . . PUNCT dti-1357 78 1 in in ADP dti-1357 78 2 drugbank drugbank NOUN dti-1357 78 3 , , PUNCT dti-1357 78 4 each each PRON dti-1357 78 5 of of ADP dti-1357 78 6 the the DET dti-1357 78 7 ∑ ∑ PUNCT dti-1357 78 8 list list NOUN dti-1357 78 9 targets target NOUN dti-1357 78 10 was be AUX dti-1357 78 11 explored explore VERB dti-1357 78 12 for for ADP dti-1357 78 13 similar similar ADJ dti-1357 78 14 therapeutic therapeutic ADJ dti-1357 78 15 targets target NOUN dti-1357 78 16 with with ADP dti-1357 78 17 the the DET dti-1357 78 18 same same ADJ dti-1357 78 19 biological biological ADJ dti-1357 78 20 function function NOUN dti-1357 78 21 . . PUNCT dti-1357 79 1 degree degree NOUN dti-1357 79 2 of of ADP dti-1357 79 3 homology homology NOUN dti-1357 79 4 was be AUX dti-1357 79 5 evaluated evaluate VERB dti-1357 79 6 using use VERB dti-1357 79 7 the the DET dti-1357 79 8 blastp blastp NOUN dti-1357 79 9 program program NOUN dti-1357 79 10 with with ADP dti-1357 79 11 an an DET dti-1357 79 12 expected expect VERB dti-1357 79 13 value value NOUN dti-1357 79 14 of of ADP dti-1357 79 15 10 10 NUM dti-1357 79 16 - - SYM dti-1357 79 17 05 05 NUM dti-1357 79 18 . . PUNCT dti-1357 80 1 presence presence NOUN dti-1357 80 2 of of ADP dti-1357 80 3 targets target NOUN dti-1357 80 4 from from ADP dti-1357 80 5 the the DET dti-1357 80 6 ∑ ∑ PROPN dti-1357 80 7 list list NOUN dti-1357 80 8 in in ADP dti-1357 80 9 drugbank drugbank NOUN dti-1357 80 10 with with ADP dti-1357 80 11 the the DET dti-1357 80 12 same same ADJ dti-1357 80 13 biological biological ADJ dti-1357 80 14 function function NOUN dti-1357 80 15 acts act VERB dti-1357 80 16 as as ADP dti-1357 80 17 evidence evidence NOUN dti-1357 80 18 for for ADP dti-1357 80 19 their their PRON dti-1357 80 20 druggable druggable ADJ dti-1357 80 21 property.39 property.39 NOUN dti-1357 80 22 in in ADP dti-1357 80 23 contrast contrast NOUN dti-1357 80 24 , , PUNCT dti-1357 80 25 their their PRON dti-1357 80 26 absence absence NOUN dti-1357 80 27 suggests suggest VERB dti-1357 80 28 the the DET dti-1357 80 29 novelty novelty NOUN dti-1357 80 30 of of ADP dti-1357 80 31 the the DET dti-1357 80 32 targets target NOUN dti-1357 80 33 , , PUNCT dti-1357 80 34 and and CCONJ dti-1357 80 35 therefore therefore ADV dti-1357 80 36 they they PRON dti-1357 80 37 are be AUX dti-1357 80 38 classified classify VERB dti-1357 80 39 as as ADP dti-1357 80 40 “ " PUNCT dti-1357 80 41 novel novel ADJ dti-1357 80 42 targets target NOUN dti-1357 80 43 . . PUNCT dti-1357 81 1 ”40 ”40 PROPN dti-1357 81 2 ranking rank VERB dti-1357 81 3 the the DET dti-1357 81 4 druggable druggable ADJ dti-1357 81 5 therapeutic therapeutic ADJ dti-1357 81 6 targets target NOUN dti-1357 81 7 based base VERB dti-1357 81 8 on on ADP dti-1357 81 9 quantitative quantitative ADJ dti-1357 81 10 characteristics characteristic NOUN dti-1357 81 11 . . PUNCT dti-1357 82 1 the the DET dti-1357 82 2 effectiveness effectiveness NOUN dti-1357 82 3 of of ADP dti-1357 82 4 a a DET dti-1357 82 5 putative putative ADJ dti-1357 82 6 target target NOUN dti-1357 82 7 may may AUX dti-1357 82 8 depend depend VERB dti-1357 82 9 on on ADP dti-1357 82 10 its its PRON dti-1357 82 11 degree degree NOUN dti-1357 82 12 of of ADP dti-1357 82 13 essentiality essentiality NOUN dti-1357 82 14 for for ADP dti-1357 82 15 the the DET dti-1357 82 16 survival survival NOUN dti-1357 82 17 of of ADP dti-1357 82 18 the the DET dti-1357 82 19 pathogenic pathogenic ADJ dti-1357 82 20 organism organism NOUN dti-1357 82 21 under under ADP dti-1357 82 22 diverse diverse ADJ dti-1357 82 23 environmental environmental ADJ dti-1357 82 24 conditions condition NOUN dti-1357 82 25 . . PUNCT dti-1357 83 1 some some DET dti-1357 83 2 targets target NOUN dti-1357 83 3 may may AUX dti-1357 83 4 prove prove VERB dti-1357 83 5 essential essential ADJ dti-1357 83 6 for for ADP dti-1357 83 7 a a DET dti-1357 83 8 limited limited ADJ dti-1357 83 9 number number NOUN dti-1357 83 10 of of ADP dti-1357 83 11 physiological physiological ADJ dti-1357 83 12 conditions condition NOUN dti-1357 83 13 , , PUNCT dti-1357 83 14 whereas whereas SCONJ dti-1357 83 15 others other NOUN dti-1357 83 16 may may AUX dti-1357 83 17 prove prove VERB dti-1357 83 18 essential essential ADJ dti-1357 83 19 irrespective irrespective ADV dti-1357 83 20 of of ADP dti-1357 83 21 environmental environmental ADJ dti-1357 83 22 conditions condition NOUN dti-1357 83 23 . . PUNCT dti-1357 84 1 the the DET dti-1357 84 2 number number NOUN dti-1357 84 3 of of ADP dti-1357 84 4 homologs homolog NOUN dti-1357 84 5 found find VERB dti-1357 84 6 in in ADP dti-1357 84 7 deg deg PROPN dti-1357 84 8 and and CCONJ dti-1357 84 9 the the DET dti-1357 84 10 number number NOUN dti-1357 84 11 of of ADP dti-1357 84 12 interactors interactor NOUN dti-1357 84 13 of of ADP dti-1357 84 14 the the DET dti-1357 84 15 particular particular ADJ dti-1357 84 16 target target NOUN dti-1357 84 17 are be AUX dti-1357 84 18 the the DET dti-1357 84 19 two two NUM dti-1357 84 20 cardinal cardinal ADJ dti-1357 84 21 factors factor NOUN dti-1357 84 22 that that PRON dti-1357 84 23 determine determine VERB dti-1357 84 24 the the DET dti-1357 84 25 degree degree NOUN dti-1357 84 26 of of ADP dti-1357 84 27 essentiality essentiality NOUN dti-1357 84 28 . . PUNCT dti-1357 85 1 moreover moreover ADV dti-1357 85 2 , , PUNCT dti-1357 85 3 the the DET dti-1357 85 4 number number NOUN dti-1357 85 5 of of ADP dti-1357 85 6 available available ADJ dti-1357 85 7 drugs drug NOUN dti-1357 85 8 present present ADJ dti-1357 85 9 in in ADP dti-1357 85 10 drugbank drugbank NOUN dti-1357 85 11 also also ADV dti-1357 85 12 determines determine VERB dti-1357 85 13 the the DET dti-1357 85 14 druggability druggability NOUN dti-1357 85 15 of of ADP dti-1357 85 16 a a DET dti-1357 85 17 particular particular ADJ dti-1357 85 18 therapeutic therapeutic ADJ dti-1357 85 19 target target NOUN dti-1357 85 20 . . PUNCT dti-1357 86 1 therefore therefore ADV dti-1357 86 2 , , PUNCT dti-1357 86 3 we we PRON dti-1357 86 4 ranked rank VERB dti-1357 86 5 the the DET dti-1357 86 6 therapeutic therapeutic ADJ dti-1357 86 7 targets target NOUN dti-1357 86 8 by by ADP dti-1357 86 9 calculating calculate VERB dti-1357 86 10 the the DET dti-1357 86 11 product product NOUN dti-1357 86 12 of of ADP dti-1357 86 13 the the DET dti-1357 86 14 number number NOUN dti-1357 86 15 of of ADP dti-1357 86 16 homologs homolog NOUN dti-1357 86 17 found find VERB dti-1357 86 18 in in ADP dti-1357 86 19 deg deg PROPN dti-1357 86 20 , , PUNCT dti-1357 86 21 the the DET dti-1357 86 22 number number NOUN dti-1357 86 23 of of ADP dti-1357 86 24 interactors interactor NOUN dti-1357 86 25 of of ADP dti-1357 86 26 the the DET dti-1357 86 27 target target NOUN dti-1357 86 28 protein protein NOUN dti-1357 86 29 , , PUNCT dti-1357 86 30 and and CCONJ dti-1357 86 31 the the DET dti-1357 86 32 number number NOUN dti-1357 86 33 of of ADP dti-1357 86 34 drugs drug NOUN dti-1357 86 35 available available ADJ dti-1357 86 36 in in ADP dti-1357 86 37 drugbank drugbank NOUN dti-1357 86 38 . . PUNCT dti-1357 87 1 the the DET dti-1357 87 2 drug drug NOUN dti-1357 87 3 target target NOUN dti-1357 87 4 score score NOUN dti-1357 87 5 was be AUX dti-1357 87 6 calculated calculate VERB dti-1357 87 7 by by ADP dti-1357 87 8 dividing divide VERB dti-1357 87 9 the the DET dti-1357 87 10 product product NOUN dti-1357 87 11 by by ADP dti-1357 87 12 100 100 NUM dti-1357 87 13 , , PUNCT dti-1357 87 14 and and CCONJ dti-1357 87 15 the the DET dti-1357 87 16 putative putative ADJ dti-1357 87 17 therapeutic therapeutic ADJ dti-1357 87 18 targets target NOUN dti-1357 87 19 were be AUX dti-1357 87 20 ranked rank VERB dti-1357 87 21 according accord VERB dti-1357 87 22 to to ADP dti-1357 87 23 the the DET dti-1357 87 24 scores score NOUN dti-1357 87 25 . . PUNCT dti-1357 88 1 results result NOUN dti-1357 88 2 in in ADP dti-1357 88 3 the the DET dti-1357 88 4 present present ADJ dti-1357 88 5 study study NOUN dti-1357 88 6 , , PUNCT dti-1357 88 7 we we PRON dti-1357 88 8 identified identify VERB dti-1357 88 9 potential potential ADJ dti-1357 88 10 therapeutic therapeutic ADJ dti-1357 88 11 targets target NOUN dti-1357 88 12 in in ADP dti-1357 88 13 m. m. NOUN dti-1357 88 14 hominis hominis PROPN dti-1357 88 15 employing employ VERB dti-1357 88 16 comparative comparative ADJ dti-1357 88 17 and and CCONJ dti-1357 88 18 subtractive subtractive ADJ dti-1357 88 19 genomic genomic NOUN dti-1357 88 20 analyses analysis NOUN dti-1357 88 21 of of ADP dti-1357 88 22 metabolic metabolic NOUN dti-1357 88 23 pathways pathway NOUN dti-1357 88 24 . . PUNCT dti-1357 89 1 we we PRON dti-1357 89 2 used use VERB dti-1357 89 3 a a DET dti-1357 89 4 systematic systematic ADJ dti-1357 89 5 hierarchical hierarchical ADJ dti-1357 89 6 approach approach NOUN dti-1357 89 7 that that PRON dti-1357 89 8 involved involve VERB dti-1357 89 9 various various ADJ dti-1357 89 10 computational computational ADJ dti-1357 89 11 tools tool NOUN dti-1357 89 12 utilization utilization NOUN dti-1357 89 13 , , PUNCT dti-1357 89 14 databases database NOUN dti-1357 89 15 search search VERB dti-1357 89 16 , , PUNCT dti-1357 89 17 and and CCONJ dti-1357 89 18 drug drug NOUN dti-1357 89 19 target target NOUN dti-1357 89 20 prioritization prioritization NOUN dti-1357 89 21 analysis analysis NOUN dti-1357 89 22 ( ( PUNCT dti-1357 89 23 fig fig NOUN dti-1357 89 24 . . NOUN dti-1357 89 25 1 1 NUM dti-1357 89 26 ) ) PUNCT dti-1357 89 27 . . PUNCT dti-1357 90 1 figure figure NOUN dti-1357 90 2 1 1 NUM dti-1357 90 3 . . PUNCT dti-1357 90 4 schematic schematic ADJ dti-1357 90 5 representation representation NOUN dti-1357 90 6 of of ADP dti-1357 90 7 workflow workflow NOUN dti-1357 90 8 for for ADP dti-1357 90 9 the the DET dti-1357 90 10 identification identification NOUN dti-1357 90 11 of of ADP dti-1357 90 12 therapeutic therapeutic ADJ dti-1357 90 13 targets target NOUN dti-1357 90 14 . . PUNCT dti-1357 91 1 http://www.la-press.com http://www.la-press.com X dti-1357 92 1 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1357 92 2 parvege parvege PROPN dti-1357 92 3 et et PROPN dti-1357 92 4 al al PROPN dti-1357 92 5 54 54 NUM dti-1357 92 6 drug drug NOUN dti-1357 92 7 target target NOUN dti-1357 92 8 insights insight VERB dti-1357 92 9 2014:8 2014:8 NUM dti-1357 92 10 table table NOUN dti-1357 92 11 1 1 NUM dti-1357 92 12 . . PUNCT dti-1357 92 13 unique unique ADJ dti-1357 92 14 and and CCONJ dti-1357 92 15 common common ADJ dti-1357 92 16 metabolic metabolic NOUN dti-1357 92 17 pathways pathway NOUN dti-1357 92 18 of of ADP dti-1357 92 19 m. m. NOUN dti-1357 92 20 hominis hominis PROPN dti-1357 92 21 with with ADP dti-1357 92 22 reference reference NOUN dti-1357 92 23 to to ADP dti-1357 92 24 h. h. PROPN dti-1357 92 25 sapiens sapiens PROPN dti-1357 92 26 . . PUNCT dti-1357 93 1 no no DET dti-1357 93 2 unique unique ADJ dti-1357 93 3 pathways pathway NOUN dti-1357 93 4 pathway pathway NOUN dti-1357 94 1 i i PROPN dti-1357 94 2 d d PROPN dti-1357 94 3 total total ADJ dti-1357 94 4 proteins protein NOUN dti-1357 94 5 1 1 NUM dti-1357 94 6 polycyclic polycyclic NOUN dti-1357 94 7 aromatic aromatic ADJ dti-1357 94 8 hydrocarbon hydrocarbon NOUN dti-1357 94 9 degradation degradation NOUN dti-1357 94 10 00624 00624 NUM dti-1357 94 11 1 1 NUM dti-1357 94 12 2 2 NUM dti-1357 94 13 methane methane NOUN dti-1357 94 14 metabolism metabolism NOUN dti-1357 94 15 00680 00680 NUM dti-1357 94 16 5 5 NUM dti-1357 94 17 3 3 NUM dti-1357 94 18 biosynthesis biosynthesis NOUN dti-1357 94 19 of of ADP dti-1357 94 20 secondary secondary ADJ dti-1357 94 21 metabolites metabolite NOUN dti-1357 94 22 01110 01110 NUM dti-1357 94 23 22 22 NUM dti-1357 94 24 4 4 NUM dti-1357 94 25 microbial microbial ADJ dti-1357 94 26 metabolism metabolism NOUN dti-1357 94 27 in in ADP dti-1357 94 28 diverse diverse ADJ dti-1357 94 29 environments environment NOUN dti-1357 94 30 01120 01120 NUM dti-1357 94 31 20 20 NUM dti-1357 94 32 5 5 NUM dti-1357 94 33 bacterial bacterial ADJ dti-1357 94 34 secretion secretion NOUN dti-1357 94 35 system system NOUN dti-1357 94 36 03070 03070 NUM dti-1357 94 37 8 8 NUM dti-1357 94 38 no no DET dti-1357 94 39 common common ADJ dti-1357 94 40 pathways pathway NOUN dti-1357 94 41 pathway pathway NOUN dti-1357 95 1 i i PROPN dti-1357 95 2 d d PROPN dti-1357 95 3 total total ADJ dti-1357 95 4 proteins protein NOUN dti-1357 95 5 1 1 NUM dti-1357 95 6 glycolysis glycolysis NOUN dti-1357 95 7 / / SYM dti-1357 95 8 gluconeogenesis gluconeogenesis NOUN dti-1357 95 9 00010 00010 NUM dti-1357 95 10 10 10 NUM dti-1357 95 11 2 2 NUM dti-1357 95 12 pentose pentose NOUN dti-1357 95 13 phosphate phosphate NOUN dti-1357 95 14 pathway pathway NOUN dti-1357 95 15 00030 00030 NUM dti-1357 95 16 9 9 NUM dti-1357 95 17 3 3 NUM dti-1357 95 18 fructose fructose NOUN dti-1357 95 19 and and CCONJ dti-1357 95 20 mannose mannose NOUN dti-1357 95 21 metabolism metabolism NOUN dti-1357 95 22 00051 00051 NUM dti-1357 95 23 4 4 NUM dti-1357 95 24 4 4 NUM dti-1357 95 25 oxidative oxidative ADJ dti-1357 95 26 phosphorylation phosphorylation NOUN dti-1357 95 27 00190 00190 NUM dti-1357 95 28 11 11 NUM dti-1357 95 29 5 5 NUM dti-1357 95 30 purine purine NOUN dti-1357 95 31 metabolism metabolism NOUN dti-1357 95 32 00230 00230 NUM dti-1357 95 33 19 19 NUM dti-1357 95 34 6 6 NUM dti-1357 95 35 pyrimidine pyrimidine NOUN dti-1357 95 36 metabolism metabolism NOUN dti-1357 95 37 00240 00240 NUM dti-1357 95 38 20 20 NUM dti-1357 95 39 7 7 NUM dti-1357 95 40 glycine glycine NOUN dti-1357 95 41 , , PUNCT dti-1357 95 42 serine serine NOUN dti-1357 95 43 and and CCONJ dti-1357 95 44 threonine threonine ADJ dti-1357 95 45 metabolism metabolism NOUN dti-1357 95 46 00260 00260 NUM dti-1357 95 47 2 2 NUM dti-1357 95 48 8 8 NUM dti-1357 95 49 cysteine cysteine NOUN dti-1357 95 50 and and CCONJ dti-1357 95 51 methionine methionine NOUN dti-1357 95 52 metabolism metabolism NOUN dti-1357 95 53 00270 00270 NUM dti-1357 95 54 3 3 NUM dti-1357 95 55 9 9 NUM dti-1357 95 56 arginine arginine NOUN dti-1357 95 57 and and CCONJ dti-1357 95 58 proline proline NOUN dti-1357 95 59 metabolism metabolism NOUN dti-1357 95 60 00330 00330 NUM dti-1357 95 61 4 4 NUM dti-1357 95 62 10 10 NUM dti-1357 95 63 selenocompound selenocompound NOUN dti-1357 95 64 metabolism metabolism NOUN dti-1357 95 65 00450 00450 NUM dti-1357 95 66 3 3 NUM dti-1357 95 67 11 11 NUM dti-1357 95 68 cyanoamino cyanoamino NOUN dti-1357 95 69 acid acid NOUN dti-1357 95 70 metabolism metabolism NOUN dti-1357 95 71 00460 00460 NUM dti-1357 95 72 2 2 NUM dti-1357 95 73 12 12 NUM dti-1357 95 74 glutathione glutathione NOUN dti-1357 95 75 metabolism metabolism NOUN dti-1357 95 76 00480 00480 NUM dti-1357 95 77 2 2 NUM dti-1357 95 78 13 13 NUM dti-1357 95 79 starch starch NOUN dti-1357 95 80 and and CCONJ dti-1357 95 81 sucrose sucrose VERB dti-1357 95 82 metabolism metabolism NOUN dti-1357 95 83 00500 00500 NUM dti-1357 95 84 3 3 NUM dti-1357 95 85 14 14 NUM dti-1357 95 86 glycerolipid glycerolipid ADJ dti-1357 95 87 metabolism metabolism NOUN dti-1357 95 88 00561 00561 NUM dti-1357 95 89 3 3 NUM dti-1357 95 90 15 15 NUM dti-1357 95 91 glycerophospholipid glycerophospholipid NOUN dti-1357 95 92 metabolism metabolism NOUN dti-1357 95 93 00564 00564 NUM dti-1357 95 94 6 6 NUM dti-1357 95 95 16 16 NUM dti-1357 95 96 pyruvate pyruvate NOUN dti-1357 95 97 metabolism metabolism NOUN dti-1357 95 98 00620 00620 NUM dti-1357 95 99 3 3 NUM dti-1357 95 100 17 17 NUM dti-1357 95 101 propanoate propanoate ADJ dti-1357 95 102 metabolism metabolism NOUN dti-1357 95 103 00640 00640 NUM dti-1357 95 104 2 2 NUM dti-1357 95 105 18 18 NUM dti-1357 95 106 one one NUM dti-1357 95 107 carbon carbon NOUN dti-1357 95 108 pool pool NOUN dti-1357 95 109 by by ADP dti-1357 95 110 folate folate NOUN dti-1357 95 111 00670 00670 NUM dti-1357 95 112 3 3 NUM dti-1357 95 113 19 19 NUM dti-1357 95 114 thiamine thiamine NOUN dti-1357 95 115 metabolism metabolism NOUN dti-1357 95 116 00730 00730 NUM dti-1357 95 117 2 2 NUM dti-1357 95 118 20 20 NUM dti-1357 95 119 riboflavin riboflavin NOUN dti-1357 95 120 metabolism metabolism NOUN dti-1357 95 121 00740 00740 NUM dti-1357 95 122 1 1 NUM dti-1357 95 123 21 21 NUM dti-1357 95 124 nicotinate nicotinate NOUN dti-1357 95 125 and and CCONJ dti-1357 95 126 nicotinamide nicotinamide NOUN dti-1357 95 127 metabolism metabolism NOUN dti-1357 95 128 00760 00760 NUM dti-1357 95 129 4 4 NUM dti-1357 95 130 22 22 NUM dti-1357 95 131 aminoacyl aminoacyl PROPN dti-1357 95 132 - - PUNCT dti-1357 95 133 trna trna NOUN dti-1357 95 134 biosynthesis biosynthesis NOUN dti-1357 95 135 00970 00970 NUM dti-1357 95 136 57 57 NUM dti-1357 95 137 23 23 NUM dti-1357 95 138 carbon carbon NOUN dti-1357 95 139 metabolism metabolism NOUN dti-1357 95 140 01200 01200 NUM dti-1357 95 141 16 16 NUM dti-1357 95 142 24 24 NUM dti-1357 95 143 biosynthesis biosynthesis NOUN dti-1357 95 144 of of ADP dti-1357 95 145 amino amino ADJ dti-1357 95 146 acids acid NOUN dti-1357 95 147 01230 01230 NUM dti-1357 95 148 16 16 NUM dti-1357 95 149 25 25 NUM dti-1357 95 150 abc abc PROPN dti-1357 95 151 transporters transporter NOUN dti-1357 95 152 02010 02010 NUM dti-1357 95 153 16 16 NUM dti-1357 95 154 26 26 NUM dti-1357 95 155 ribosome ribosome NOUN dti-1357 95 156 03010 03010 NUM dti-1357 95 157 58 58 NUM dti-1357 95 158 27 27 NUM dti-1357 95 159 rna rna NOUN dti-1357 95 160 degradation degradation NOUN dti-1357 95 161 03018 03018 NUM dti-1357 95 162 5 5 NUM dti-1357 95 163 28 28 NUM dti-1357 95 164 rna rna NOUN dti-1357 95 165 polymerase polymerase NOUN dti-1357 95 166 03020 03020 NUM dti-1357 95 167 3 3 NUM dti-1357 95 168 29 29 NUM dti-1357 95 169 dna dna NOUN dti-1357 95 170 replication replication NOUN dti-1357 95 171 03030 03030 NUM dti-1357 95 172 12 12 NUM dti-1357 95 173 30 30 NUM dti-1357 95 174 protein protein NOUN dti-1357 95 175 export export NOUN dti-1357 95 176 03060 03060 NUM dti-1357 95 177 9 9 NUM dti-1357 95 178 31 31 NUM dti-1357 95 179 base base NOUN dti-1357 95 180 excision excision NOUN dti-1357 95 181 repair repair NOUN dti-1357 95 182 03410 03410 NUM dti-1357 95 183 5 5 NUM dti-1357 95 184 32 32 NUM dti-1357 95 185 nucleotide nucleotide NOUN dti-1357 95 186 excision excision NOUN dti-1357 95 187 repair repair NOUN dti-1357 95 188 03420 03420 NUM dti-1357 95 189 6 6 NUM dti-1357 95 190 33 33 NUM dti-1357 95 191 mismatch mismatch NOUN dti-1357 95 192 repair repair NOUN dti-1357 95 193 03430 03430 NUM dti-1357 95 194 9 9 NUM dti-1357 95 195 34 34 NUM dti-1357 95 196 homologous homologous ADJ dti-1357 95 197 recombination recombination NOUN dti-1357 95 198 03440 03440 NUM dti-1357 95 199 14 14 NUM dti-1357 95 200 35 35 NUM dti-1357 95 201 sulfur sulfur NOUN dti-1357 95 202 relay relay NOUN dti-1357 95 203 system system NOUN dti-1357 95 204 04122 04122 NUM dti-1357 95 205 2 2 NUM dti-1357 95 206 comparison comparison NOUN dti-1357 95 207 between between ADP dti-1357 95 208 m. m. NOUN dti-1357 95 209 hominis hominis PROPN dti-1357 95 210 and and CCONJ dti-1357 95 211 h. h. PROPN dti-1357 95 212 sapiens sapien VERB dti-1357 95 213 metabolic metabolic NOUN dti-1357 95 214 pathways pathway NOUN dti-1357 95 215 identified identify VERB dti-1357 95 216 five five NUM dti-1357 95 217 unique unique ADJ dti-1357 95 218 pathways pathway NOUN dti-1357 95 219 and and CCONJ dti-1357 95 220 35 35 NUM dti-1357 95 221 common common ADJ dti-1357 95 222 pathways pathway NOUN dti-1357 95 223 . . PUNCT dti-1357 96 1 primary primary ADJ dti-1357 96 2 information information NOUN dti-1357 96 3 about about ADP dti-1357 96 4 the the DET dti-1357 96 5 metabolic metabolic NOUN dti-1357 96 6 pathways pathway NOUN dti-1357 96 7 of of ADP dti-1357 96 8 m. m. NOUN dti-1357 96 9 hominis hominis PROPN dti-1357 96 10 and and CCONJ dti-1357 96 11 humans human NOUN dti-1357 96 12 was be AUX dti-1357 96 13 retrieved retrieve VERB dti-1357 96 14 from from ADP dti-1357 96 15 the the DET dti-1357 96 16 kegg kegg NOUN dti-1357 96 17 database database NOUN dti-1357 96 18 . . PUNCT dti-1357 97 1 currently currently ADV dti-1357 97 2 , , PUNCT dti-1357 97 3 the the DET dti-1357 97 4 kegg kegg NOUN dti-1357 97 5 database database NOUN dti-1357 97 6 contains contain VERB dti-1357 97 7 information information NOUN dti-1357 97 8 about about ADP dti-1357 97 9 40 40 NUM dti-1357 97 10 metabolic metabolic NOUN dti-1357 97 11 pathways pathway NOUN dti-1357 97 12 for for ADP dti-1357 97 13 m. m. NOUN dti-1357 97 14 hominis hominis X dti-1357 97 15 ( ( PUNCT dti-1357 97 16 table table NOUN dti-1357 97 17 1 1 NUM dti-1357 97 18 ) ) PUNCT dti-1357 97 19 . . PUNCT dti-1357 98 1 comparison comparison NOUN dti-1357 98 2 with with ADP dti-1357 98 3 human human ADJ dti-1357 98 4 pathways pathway NOUN dti-1357 98 5 revealed reveal VERB dti-1357 98 6 five five NUM dti-1357 98 7 pathways pathway NOUN dti-1357 98 8 containing contain VERB dti-1357 98 9 36 36 NUM dti-1357 98 10 proteins protein NOUN dti-1357 98 11 as as ADV dti-1357 98 12 unique unique ADJ dti-1357 98 13 to to ADP dti-1357 98 14 m. m. NOUN dti-1357 98 15 hominis hominis PROPN dti-1357 98 16 while while SCONJ dti-1357 98 17 the the DET dti-1357 98 18 remaining remain VERB dti-1357 98 19 35 35 NUM dti-1357 98 20 pathways pathway NOUN dti-1357 98 21 containing contain VERB dti-1357 98 22 197 197 NUM dti-1357 98 23 proteins protein NOUN dti-1357 98 24 as as ADP dti-1357 98 25 common common ADJ dti-1357 98 26 to to ADP dti-1357 98 27 m. m. NOUN dti-1357 98 28 hominis hominis PROPN dti-1357 98 29 and and CCONJ dti-1357 98 30 humans human NOUN dti-1357 98 31 . . PUNCT dti-1357 99 1 thirty thirty NUM dti-1357 99 2 - - PUNCT dti-1357 99 3 five five NUM dti-1357 99 4 http://www.la-press.com http://www.la-press.com X dti-1357 99 5 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1357 99 6 identification identification NOUN dti-1357 99 7 of of ADP dti-1357 99 8 therapeutic therapeutic ADJ dti-1357 99 9 targets target NOUN dti-1357 99 10 in in ADP dti-1357 99 11 mycoplasma mycoplasma NOUN dti-1357 99 12 hominis hominis X dti-1357 99 13 55drug 55drug X dti-1357 99 14 target target NOUN dti-1357 99 15 insights insight VERB dti-1357 99 16 2014:8 2014:8 NUM dti-1357 99 17 out out ADP dti-1357 99 18 of of ADP dti-1357 99 19 36 36 NUM dti-1357 99 20 proteins protein NOUN dti-1357 99 21 of of ADP dti-1357 99 22 unique unique ADJ dti-1357 99 23 pathways pathway NOUN dti-1357 99 24 are be AUX dti-1357 99 25 also also ADV dti-1357 99 26 present present ADJ dti-1357 99 27 in in ADP dti-1357 99 28 common common ADJ dti-1357 99 29 pathways pathway NOUN dti-1357 99 30 . . PUNCT dti-1357 100 1 after after ADP dti-1357 100 2 removing remove VERB dti-1357 100 3 redundant redundant ADJ dti-1357 100 4 proteins protein NOUN dti-1357 100 5 , , PUNCT dti-1357 100 6 a a DET dti-1357 100 7 total total NOUN dti-1357 100 8 of of ADP dti-1357 100 9 198 198 NUM dti-1357 100 10 protein protein NOUN dti-1357 100 11 sequences sequence NOUN dti-1357 100 12 were be AUX dti-1357 100 13 obtained obtain VERB dti-1357 100 14 from from ADP dti-1357 100 15 the the DET dti-1357 100 16 ncbi ncbi PROPN dti-1357 100 17 database database PROPN dti-1357 100 18 . . PUNCT dti-1357 101 1 homology homology NOUN dti-1357 101 2 search search NOUN dti-1357 101 3 revealed reveal VERB dti-1357 101 4 179 179 NUM dti-1357 101 5 putative putative ADJ dti-1357 101 6 essential essential ADJ dti-1357 101 7 proteins protein NOUN dti-1357 101 8 for for ADP dti-1357 101 9 m. m. NOUN dti-1357 101 10 hominis homini NOUN dti-1357 101 11 . . PUNCT dti-1357 102 1 proteins protein NOUN dti-1357 102 2 that that PRON dti-1357 102 3 are be AUX dti-1357 102 4 required require VERB dti-1357 102 5 by by ADP dti-1357 102 6 pathogenic pathogenic ADJ dti-1357 102 7 microorganisms microorganism NOUN dti-1357 102 8 to to PART dti-1357 102 9 survive survive VERB dti-1357 102 10 are be AUX dti-1357 102 11 called call VERB dti-1357 102 12 essential essential ADJ dti-1357 102 13 proteins protein NOUN dti-1357 102 14 . . PUNCT dti-1357 103 1 essential essential ADJ dti-1357 103 2 proteins protein NOUN dti-1357 103 3 are be AUX dti-1357 103 4 prime prime ADJ dti-1357 103 5 targets target NOUN dti-1357 103 6 for for ADP dti-1357 103 7 drugs drug NOUN dti-1357 103 8 and and CCONJ dti-1357 103 9 vaccine vaccine NOUN dti-1357 103 10 development development NOUN dti-1357 103 11 . . PUNCT dti-1357 104 1 to to PART dti-1357 104 2 identify identify VERB dti-1357 104 3 the the DET dti-1357 104 4 essential essential ADJ dti-1357 104 5 proteins protein NOUN dti-1357 104 6 , , PUNCT dti-1357 104 7 198 198 NUM dti-1357 104 8 proteins protein NOUN dti-1357 104 9 of of ADP dti-1357 104 10 common common ADJ dti-1357 104 11 and and CCONJ dti-1357 104 12 unique unique ADJ dti-1357 104 13 pathways pathway NOUN dti-1357 104 14 were be AUX dti-1357 104 15 compared compare VERB dti-1357 104 16 against against ADP dti-1357 104 17 the the DET dti-1357 104 18 deg deg PROPN dti-1357 104 19 database database NOUN dti-1357 104 20 . . PUNCT dti-1357 105 1 out out ADP dti-1357 105 2 of of ADP dti-1357 105 3 198 198 NUM dti-1357 105 4 input input NOUN dti-1357 105 5 proteins protein NOUN dti-1357 105 6 , , PUNCT dti-1357 105 7 179 179 NUM dti-1357 105 8 proteins protein NOUN dti-1357 105 9 were be AUX dti-1357 105 10 found find VERB dti-1357 105 11 to to PART dti-1357 105 12 be be AUX dti-1357 105 13 essential essential ADJ dti-1357 105 14 for for ADP dti-1357 105 15 the the DET dti-1357 105 16 pathogen pathogen NOUN dti-1357 105 17 . . PUNCT dti-1357 106 1 the the DET dti-1357 106 2 distribution distribution NOUN dti-1357 106 3 of of ADP dti-1357 106 4 the the DET dti-1357 106 5 179 179 NUM dti-1357 106 6 identified identify VERB dti-1357 106 7 essential essential ADJ dti-1357 106 8 proteins protein NOUN dti-1357 106 9 in in ADP dti-1357 106 10 each each PRON dti-1357 106 11 of of ADP dti-1357 106 12 the the DET dti-1357 106 13 22 22 NUM dti-1357 106 14 bacteria bacteria NOUN dti-1357 106 15 of of ADP dti-1357 106 16 deg deg PROPN dti-1357 106 17 is be AUX dti-1357 106 18 presented present VERB dti-1357 106 19 in in ADP dti-1357 106 20 figure figure NOUN dti-1357 106 21 2 2 NUM dti-1357 106 22 . . PUNCT dti-1357 106 23 comparative comparative ADJ dti-1357 106 24 analysis analysis NOUN dti-1357 106 25 of of ADP dti-1357 106 26 the the DET dti-1357 106 27 essential essential ADJ dti-1357 106 28 proteins protein NOUN dti-1357 106 29 revealed reveal VERB dti-1357 106 30 59 59 NUM dti-1357 106 31 of of ADP dti-1357 106 32 them they PRON dti-1357 106 33 as as ADP dti-1357 106 34 non non ADJ dti-1357 106 35 - - NOUN dti-1357 106 36 host host NOUN dti-1357 106 37 . . PUNCT dti-1357 107 1 the the DET dti-1357 107 2 aim aim NOUN dti-1357 107 3 of of ADP dti-1357 107 4 the the DET dti-1357 107 5 non non ADJ dti-1357 107 6 - - ADJ dti-1357 107 7 homology homology ADJ dti-1357 107 8 analysis analysis NOUN dti-1357 107 9 was be AUX dti-1357 107 10 to to PART dti-1357 107 11 identify identify VERB dti-1357 107 12 pathogen pathogen NOUN dti-1357 107 13 - - PUNCT dti-1357 107 14 specific specific ADJ dti-1357 107 15 proteins protein NOUN dti-1357 107 16 that that PRON dti-1357 107 17 are be AUX dti-1357 107 18 nonhomologous nonhomologous ADJ dti-1357 107 19 to to ADP dti-1357 107 20 the the DET dti-1357 107 21 host host NOUN dti-1357 107 22 . . PUNCT dti-1357 108 1 this this DET dti-1357 108 2 step step NOUN dti-1357 108 3 is be AUX dti-1357 108 4 important important ADJ dti-1357 108 5 to to PART dti-1357 108 6 avoid avoid VERB dti-1357 108 7 undesirable undesirable ADJ dti-1357 108 8 cross cross NOUN dti-1357 108 9 - - NOUN dti-1357 108 10 reactivity reactivity NOUN dti-1357 108 11 of of ADP dti-1357 108 12 the the DET dti-1357 108 13 drug drug NOUN dti-1357 108 14 arising arise VERB dti-1357 108 15 from from ADP dti-1357 108 16 its its PRON dti-1357 108 17 binding binding NOUN dti-1357 108 18 to to ADP dti-1357 108 19 the the DET dti-1357 108 20 active active ADJ dti-1357 108 21 sites site NOUN dti-1357 108 22 of of ADP dti-1357 108 23 the the DET dti-1357 108 24 homologous homologous ADJ dti-1357 108 25 proteins protein NOUN dti-1357 108 26 in in ADP dti-1357 108 27 the the DET dti-1357 108 28 host host NOUN dti-1357 108 29 . . PUNCT dti-1357 109 1 out out ADP dti-1357 109 2 of of ADP dti-1357 109 3 179 179 NUM dti-1357 109 4 proteins protein NOUN dti-1357 109 5 , , PUNCT dti-1357 109 6 blast blast NOUN dti-1357 109 7 search search NOUN dti-1357 109 8 of of ADP dti-1357 109 9 essential essential ADJ dti-1357 109 10 proteins protein NOUN dti-1357 109 11 against against ADP dti-1357 109 12 nonredundant nonredundant ADJ dti-1357 109 13 database database NOUN dti-1357 109 14 of of ADP dti-1357 109 15 h. h. PROPN dti-1357 109 16 sapiens sapiens PROPN dti-1357 109 17 identified identify VERB dti-1357 109 18 only only ADV dti-1357 109 19 59 59 NUM dti-1357 109 20 proteins protein NOUN dti-1357 109 21 as as ADP dti-1357 109 22 non non ADJ dti-1357 109 23 - - ADJ dti-1357 109 24 host host ADJ dti-1357 109 25 but but CCONJ dti-1357 109 26 essential essential ADJ dti-1357 109 27 proteins protein NOUN dti-1357 109 28 . . PUNCT dti-1357 110 1 exclusion exclusion NOUN dti-1357 110 2 of of ADP dti-1357 110 3 high high ADJ dti-1357 110 4 mw mw ADJ dti-1357 110 5 proteins protein NOUN dti-1357 110 6 generated generate VERB dti-1357 110 7 a a DET dti-1357 110 8 list list NOUN dti-1357 110 9 of of ADP dti-1357 110 10 57 57 NUM dti-1357 110 11 putative putative ADJ dti-1357 110 12 therapeutic therapeutic ADJ dti-1357 110 13 targets target NOUN dti-1357 110 14 . . PUNCT dti-1357 111 1 proteins protein NOUN dti-1357 111 2 of of ADP dti-1357 111 3 low low ADJ dti-1357 111 4 mw mw NOUN dti-1357 111 5 are be AUX dti-1357 111 6 preferable preferable ADJ dti-1357 111 7 as as ADP dti-1357 111 8 drug drug NOUN dti-1357 111 9 targets target NOUN dti-1357 111 10 because because SCONJ dti-1357 111 11 of of ADP dti-1357 111 12 their their PRON dti-1357 111 13 solubility solubility NOUN dti-1357 111 14 and and CCONJ dti-1357 111 15 ease ease NOUN dti-1357 111 16 of of ADP dti-1357 111 17 purification purification NOUN dti-1357 111 18 . . PUNCT dti-1357 112 1 by by ADP dti-1357 112 2 mw mw VERB dti-1357 112 3 analysis analysis NOUN dti-1357 112 4 through through ADP dti-1357 112 5 online online ADJ dti-1357 112 6 tools tool NOUN dti-1357 112 7 and and CCONJ dti-1357 112 8 literature literature NOUN dti-1357 112 9 study study NOUN dti-1357 112 10 , , PUNCT dti-1357 112 11 57 57 NUM dti-1357 112 12 out out ADP dti-1357 112 13 of of ADP dti-1357 112 14 59 59 NUM dti-1357 112 15 proteins protein NOUN dti-1357 112 16 having having AUX dti-1357 112 17 mw mw VERB dti-1357 112 18 below below ADP dti-1357 112 19 110 110 NUM dti-1357 112 20     SPACE dti-1357 112 21 kda kda NOUN dti-1357 112 22 were be AUX dti-1357 112 23 short short ADJ dti-1357 112 24 listed list VERB dti-1357 112 25 ( ( PUNCT dti-1357 112 26 ∑ ∑ PART dti-1357 112 27 list list NOUN dti-1357 112 28 ) ) PUNCT dti-1357 112 29 for for ADP dti-1357 112 30 the the DET dti-1357 112 31 qualitative qualitative ADJ dti-1357 112 32 characterization characterization NOUN dti-1357 112 33 . . PUNCT dti-1357 113 1 although although SCONJ dti-1357 113 2 no no DET dti-1357 113 3 experimentally experimentally ADV dti-1357 113 4 solved solve VERB dti-1357 113 5 3 3 NUM dti-1357 113 6 - - SYM dti-1357 113 7 d d NOUN dti-1357 113 8 structure structure NOUN dti-1357 113 9 was be AUX dti-1357 113 10 found find VERB dti-1357 113 11 for for ADP dti-1357 113 12 the the DET dti-1357 113 13 ∑ ∑ ADV dti-1357 113 14 listed list VERB dti-1357 113 15 proteins protein NOUN dti-1357 113 16 , , PUNCT dti-1357 113 17 computationally computationally ADV dti-1357 113 18 annotated annotate VERB dti-1357 113 19 3 3 NUM dti-1357 113 20 - - SYM dti-1357 113 21 d d NOUN dti-1357 113 22 models model NOUN dti-1357 113 23 were be AUX dti-1357 113 24 available available ADJ dti-1357 113 25 for for ADP dti-1357 113 26 16 16 NUM dti-1357 113 27 proteins protein NOUN dti-1357 113 28 of of ADP dti-1357 113 29 the the DET dti-1357 113 30 ∑ ∑ PROPN dti-1357 113 31 list list NOUN dti-1357 113 32 in in ADP dti-1357 113 33 the the DET dti-1357 113 34 modbase modbase PROPN dti-1357 113 35 database database NOUN dti-1357 113 36 . . PUNCT dti-1357 114 1 cellular cellular ADJ dti-1357 114 2 localization localization NOUN dti-1357 114 3 analysis analysis NOUN dti-1357 114 4 mapped map VERB dti-1357 114 5 the the DET dti-1357 114 6 proteins protein NOUN dti-1357 114 7 of of ADP dti-1357 114 8 ∑ ∑ PUNCT dti-1357 114 9 list list NOUN dti-1357 114 10 to to ADP dti-1357 114 11 different different ADJ dti-1357 114 12 cellular cellular ADJ dti-1357 114 13 locations location NOUN dti-1357 114 14 . . PUNCT dti-1357 115 1 target target NOUN dti-1357 115 2 proteins protein NOUN dti-1357 115 3 found find VERB dti-1357 115 4 in in ADP dti-1357 115 5 the the DET dti-1357 115 6 cytoplasm cytoplasm NOUN dti-1357 115 7 can can AUX dti-1357 115 8 be be AUX dti-1357 115 9 used use VERB dti-1357 115 10 as as ADP dti-1357 115 11 potential potential ADJ dti-1357 115 12 drug drug NOUN dti-1357 115 13 targets target NOUN dti-1357 115 14 , , PUNCT dti-1357 115 15 whereas whereas ADV dti-1357 115 16 extracellular extracellular ADJ dti-1357 115 17 and and CCONJ dti-1357 115 18 membrane membrane NOUN dti-1357 115 19 - - PUNCT dti-1357 115 20 bound bind VERB dti-1357 115 21 proteins protein NOUN dti-1357 115 22 can can AUX dti-1357 115 23 work work VERB dti-1357 115 24 as as ADP dti-1357 115 25 probable probable ADJ dti-1357 115 26 vaccine vaccine NOUN dti-1357 115 27 targets.28 targets.28 PROPN dti-1357 115 28 various various ADJ dti-1357 115 29 online online ADJ dti-1357 115 30 tools tool NOUN dti-1357 115 31 were be AUX dti-1357 115 32 used use VERB dti-1357 115 33 for for ADP dti-1357 115 34 the the DET dti-1357 115 35 prediction prediction NOUN dti-1357 115 36 of of ADP dti-1357 115 37 subcellular subcellular ADJ dti-1357 115 38 localization localization NOUN dti-1357 115 39 and and CCONJ dti-1357 115 40 membrane membrane NOUN dti-1357 115 41 topology topology NOUN dti-1357 115 42 . . PUNCT dti-1357 116 1 based base VERB dti-1357 116 2 on on ADP dti-1357 116 3 the the DET dti-1357 116 4 localization localization NOUN dti-1357 116 5 score score NOUN dti-1357 116 6 , , PUNCT dti-1357 116 7 psortb psortb PROPN dti-1357 116 8 predicted predict VERB dti-1357 116 9 the the DET dti-1357 116 10 location location NOUN dti-1357 116 11 of of ADP dti-1357 116 12 32 32 NUM dti-1357 116 13 targets target NOUN dti-1357 116 14 in in ADP dti-1357 116 15 the the DET dti-1357 116 16 cytoplasm cytoplasm NOUN dti-1357 116 17 and and CCONJ dti-1357 116 18 13 13 NUM dti-1357 116 19 in in ADP dti-1357 116 20 the the DET dti-1357 116 21 membrane membrane NOUN dti-1357 116 22 . . PUNCT dti-1357 117 1 however however ADV dti-1357 117 2 , , PUNCT dti-1357 117 3 12 12 NUM dti-1357 117 4 proteins protein NOUN dti-1357 117 5 could could AUX dti-1357 117 6 not not PART dti-1357 117 7 be be AUX dti-1357 117 8 mapped map VERB dti-1357 117 9 to to ADP dti-1357 117 10 any any DET dti-1357 117 11 cellular cellular ADJ dti-1357 117 12 location location NOUN dti-1357 117 13 with with ADP dti-1357 117 14 this this DET dti-1357 117 15 software software NOUN dti-1357 117 16 . . PUNCT dti-1357 118 1 cello cello PROPN dti-1357 118 2 predicted predict VERB dti-1357 118 3 43 43 NUM dti-1357 118 4 targets target NOUN dti-1357 118 5 in in ADP dti-1357 118 6 the the DET dti-1357 118 7 cytoplasm cytoplasm NOUN dti-1357 118 8 and and CCONJ dti-1357 118 9 14 14 NUM dti-1357 118 10 in in ADP dti-1357 118 11 the the DET dti-1357 118 12 membrane membrane NOUN dti-1357 118 13 ( ( PUNCT dti-1357 118 14 table table NOUN dti-1357 118 15 2 2 NUM dti-1357 118 16 ) ) PUNCT dti-1357 118 17 . . PUNCT dti-1357 119 1 this this DET dti-1357 119 2 tool tool NOUN dti-1357 119 3 was be AUX dti-1357 119 4 able able ADJ dti-1357 119 5 to to PART dti-1357 119 6 predict predict VERB dti-1357 119 7 the the DET dti-1357 119 8 location location NOUN dti-1357 119 9 of of ADP dti-1357 119 10 12 12 NUM dti-1357 119 11 targets target NOUN dti-1357 119 12 previously previously ADV dti-1357 119 13 uncharacterized uncharacterize VERB dti-1357 119 14 by by ADP dti-1357 119 15 psortb psortb NOUN dti-1357 119 16 , , PUNCT dti-1357 119 17 and and CCONJ dti-1357 119 18 the the DET dti-1357 119 19 result result NOUN dti-1357 119 20 of of ADP dti-1357 119 21 cello cello NOUN dti-1357 119 22 was be AUX dti-1357 119 23 in in ADP dti-1357 119 24 agreement agreement NOUN dti-1357 119 25 with with ADP dti-1357 119 26 topcons topcon NOUN dti-1357 119 27 prediction prediction NOUN dti-1357 119 28 as as ADV dti-1357 119 29 well well ADV dti-1357 119 30 . . PUNCT dti-1357 120 1 psortb psortb ADJ dti-1357 120 2 prediction prediction NOUN dti-1357 120 3 varied varied ADJ dti-1357 120 4 with with ADP dti-1357 120 5 cello cello NOUN dti-1357 120 6 and and CCONJ dti-1357 120 7 topcons topcon NOUN dti-1357 120 8 in in ADP dti-1357 120 9 the the DET dti-1357 120 10 case case NOUN dti-1357 120 11 of of ADP dti-1357 120 12 only only ADV dti-1357 120 13 one one NUM dti-1357 120 14 protein protein NOUN dti-1357 120 15 , , PUNCT dti-1357 120 16 mho_3910 mho_3910 PROPN dti-1357 120 17 . . NOUN dti-1357 120 18 0 0 NUM dti-1357 120 19 20 20 NUM dti-1357 120 20 40 40 NUM dti-1357 120 21 60 60 NUM dti-1357 120 22 80 80 NUM dti-1357 120 23 100 100 NUM dti-1357 120 24 120 120 NUM dti-1357 120 25 140 140 NUM dti-1357 120 26 160 160 NUM dti-1357 120 27 180 180 NUM dti-1357 120 28 a a DET dti-1357 120 29 ci ci NOUN dti-1357 120 30 ne ne NOUN dti-1357 120 31 to to PART dti-1357 120 32 ba ba VERB dti-1357 121 1 ct ct INTJ dti-1357 122 1 er er INTJ dti-1357 122 2 b b X dti-1357 123 1 ay ay INTJ dti-1357 123 2 ly ly X dti-1357 124 1 i i PRON dti-1357 124 2 a a PRON dti-1357 125 1 d d X dti-1357 125 2 p p ADJ dti-1357 125 3 1 1 PROPN dti-1357 125 4 b b PROPN dti-1357 125 5 ac ac PROPN dti-1357 125 6 ill ill PROPN dti-1357 125 7 us we PRON dti-1357 125 8 s s VERB dti-1357 125 9 ub ub ADP dti-1357 125 10 til til ADV dti-1357 125 11 is be AUX dti-1357 125 12 1 1 NUM dti-1357 125 13 68 68 NUM dti-1357 125 14 b b NUM dti-1357 125 15 ac ac ADP dti-1357 125 16 te te PROPN dti-1357 125 17 ro ro PROPN dti-1357 126 1 i i PROPN dti-1357 126 2 d d PROPN dti-1357 126 3 es es PROPN dti-1357 126 4 fr fr PROPN dti-1357 126 5 ag ag PROPN dti-1357 126 6 ili ili PROPN dti-1357 126 7 s s PART dti-1357 126 8 63 63 NUM dti-1357 126 9 8r 8r NUM dti-1357 126 10 b b NOUN dti-1357 126 11 ac ac ADP dti-1357 126 12 te te PROPN dti-1357 126 13 ro ro PROPN dti-1357 127 1 i i PROPN dti-1357 127 2 d d PROPN dti-1357 127 3 es es X dti-1357 127 4 th th INTJ dti-1357 127 5 et et NOUN dti-1357 127 6 ai ai VERB dti-1357 127 7 ot ot INTJ dti-1357 127 8 ao ao PROPN dti-1357 127 9 m m PROPN dti-1357 127 10 ic ic PROPN dti-1357 127 11 ro ro PROPN dti-1357 128 1 n n PROPN dti-1357 128 2 v v PROPN dti-1357 128 3 p p PROPN dti-1357 128 4 i-5 i-5 PROPN dti-1357 128 5 48 48 NUM dti-1357 128 6 2 2 NUM dti-1357 128 7 b b NOUN dti-1357 128 8 ur ur INTJ dti-1357 128 9 kh kh PROPN dti-1357 128 10 ol ol PROPN dti-1357 128 11 de de PROPN dti-1357 128 12 ria ria PROPN dti-1357 128 13 p p PROPN dti-1357 128 14 se se PROPN dti-1357 128 15 ud ud INTJ dti-1357 128 16 om om PROPN dti-1357 129 1 al al PROPN dti-1357 129 2 le le PROPN dti-1357 130 1 i i PROPN dti-1357 130 2 k k PROPN dti-1357 131 1 96 96 NUM dti-1357 131 2 24 24 NUM dti-1357 131 3 3 3 NUM dti-1357 131 4 b b NOUN dti-1357 131 5 ur ur INTJ dti-1357 131 6 kh kh PROPN dti-1357 131 7 ol ol PROPN dti-1357 131 8 de de PROPN dti-1357 131 9 ria ria PROPN dti-1357 131 10 th th X dti-1357 131 11 ai ai VERB dti-1357 131 12 la la ADV dti-1357 131 13 nd nd ADV dti-1357 131 14 en en X dti-1357 131 15 si si X dti-1357 131 16 s s PROPN dti-1357 131 17 e e NOUN dti-1357 131 18 26 26 NUM dti-1357 131 19 4 4 NUM dti-1357 131 20 c c NOUN dti-1357 131 21 am be AUX dti-1357 131 22 py py INTJ dti-1357 132 1 lo lo INTJ dti-1357 132 2 ba ba PROPN dti-1357 133 1 ct ct INTJ dti-1357 133 2 er er INTJ dti-1357 133 3 je je PROPN dti-1357 133 4 ju ju PROPN dti-1357 133 5 ni ni PROPN dti-1357 133 6 s s PROPN dti-1357 133 7 ub ub ADJ dti-1357 133 8 sp sp NOUN dti-1357 133 9 . . PUNCT dti-1357 134 1 j j PROPN dti-1357 135 1 ej ej PROPN dti-1357 135 2 un un PROPN dti-1357 135 3 i i PRON dti-1357 135 4 … … PUNCT dti-1357 135 5 c c PROPN dti-1357 135 6 au au PROPN dti-1357 136 1 lo lo PROPN dti-1357 136 2 ba ba NOUN dti-1357 137 1 ct ct INTJ dti-1357 138 1 er er INTJ dti-1357 138 2 c c X dti-1357 138 3 re re X dti-1357 138 4 sc sc PROPN dti-1357 138 5 en en PROPN dti-1357 138 6 tu tu PROPN dti-1357 138 7 s s PROPN dti-1357 138 8 e e X dti-1357 138 9 sc sc PROPN dti-1357 138 10 he he PRON dti-1357 138 11 ric ric PROPN dti-1357 138 12 hi hi INTJ dti-1357 138 13 a a DET dti-1357 138 14 co co X dti-1357 138 15 li li PROPN dti-1357 138 16 m m PROPN dti-1357 138 17 g g PROPN dti-1357 138 18 16 16 NUM dti-1357 138 19 55 55 NUM dti-1357 139 1 i i NOUN dti-1357 139 2 e e PROPN dti-1357 140 1 sc sc PROPN dti-1357 141 1 he he PRON dti-1357 141 2 ric ric PROPN dti-1357 141 3 hi hi INTJ dti-1357 141 4 a a DET dti-1357 141 5 co co X dti-1357 141 6 li li PROPN dti-1357 141 7 m m PROPN dti-1357 141 8 g g PROPN dti-1357 141 9 16 16 NUM dti-1357 141 10 55 55 NUM dti-1357 141 11 ii ii NOUN dti-1357 141 12 fr fr NOUN dti-1357 141 13 an an DET dti-1357 141 14 ci ci PROPN dti-1357 141 15 se se X dti-1357 141 16 lla lla PROPN dti-1357 142 1 n n PROPN dti-1357 142 2 ov ov INTJ dti-1357 142 3 ic ic INTJ dti-1357 143 1 i i PROPN dti-1357 143 2 d d PROPN dti-1357 143 3 a a DET dti-1357 143 4 u u NOUN dti-1357 143 5 11 11 NUM dti-1357 143 6 2 2 NUM dti-1357 143 7 h h NOUN dti-1357 143 8 ae ae PROPN dti-1357 143 9 m m VERB dti-1357 143 10 op op NOUN dti-1357 143 11 hi hi INTJ dti-1357 144 1 lu lu NOUN dti-1357 144 2 s s PROPN dti-1357 144 3 in in ADP dti-1357 144 4 flu flu PROPN dti-1357 144 5 en en X dti-1357 144 6 za za PROPN dti-1357 144 7 e e PROPN dti-1357 144 8 r r NOUN dti-1357 144 9 d d X dti-1357 144 10 k k PROPN dti-1357 144 11 w w PROPN dti-1357 145 1 20 20 NUM dti-1357 145 2 h h NOUN dti-1357 146 1 el el PROPN dti-1357 146 2 ic ic PROPN dti-1357 146 3 ob ob INTJ dti-1357 147 1 ac ac ADV dti-1357 147 2 te te PROPN dti-1357 147 3 r r NOUN dti-1357 147 4 p p NOUN dti-1357 147 5 yl yl NOUN dti-1357 148 1 or or CCONJ dti-1357 148 2 i i PRON dti-1357 148 3 2 2 NUM dti-1357 148 4 66 66 NUM dti-1357 148 5 95 95 NUM dti-1357 148 6 m m NOUN dti-1357 148 7 yc yc NOUN dti-1357 148 8 ob ob INTJ dti-1357 148 9 ac ac PROPN dti-1357 148 10 te te PROPN dti-1357 148 11 riu riu PROPN dti-1357 148 12 m m PROPN dti-1357 148 13 tu tu PROPN dti-1357 148 14 be be PROPN dti-1357 148 15 rc rc PROPN dti-1357 148 16 ul ul INTJ dti-1357 148 17 os os PROPN dti-1357 148 18 is be AUX dti-1357 148 19 h h PRON dti-1357 148 20 37 37 NUM dti-1357 148 21 r r NOUN dti-1357 148 22 v v NOUN dti-1357 148 23 m m NOUN dti-1357 148 24 yc yc NOUN dti-1357 148 25 ob ob INTJ dti-1357 148 26 ac ac PROPN dti-1357 148 27 te te PROPN dti-1357 148 28 riu riu PROPN dti-1357 148 29 m m PROPN dti-1357 148 30 tu tu PROPN dti-1357 148 31 be be PROPN dti-1357 148 32 rc rc PROPN dti-1357 149 1 ul ul INTJ dti-1357 149 2 os os PROPN dti-1357 149 3 is be AUX dti-1357 149 4 h h PRON dti-1357 149 5 37 37 NUM dti-1357 149 6 r r NOUN dti-1357 149 7 v v NOUN dti-1357 149 8 ii ii NOUN dti-1357 149 9 m m NOUN dti-1357 149 10 yc yc NOUN dti-1357 149 11 ob ob INTJ dti-1357 150 1 ac ac PROPN dti-1357 150 2 te te PROPN dti-1357 150 3 riu riu PROPN dti-1357 150 4 m m PROPN dti-1357 150 5 tu tu PROPN dti-1357 150 6 be be PROPN dti-1357 150 7 rc rc PROPN dti-1357 150 8 ul ul INTJ dti-1357 150 9 os os PROPN dti-1357 150 10 is be AUX dti-1357 150 11 h h PRON dti-1357 150 12 37 37 NUM dti-1357 150 13 r r NOUN dti-1357 150 14 v v NOUN dti-1357 150 15 iii iii NOUN dti-1357 150 16 m m NOUN dti-1357 150 17 yc yc NOUN dti-1357 150 18 op op NOUN dti-1357 150 19 la la PROPN dti-1357 150 20 sm sm PROPN dti-1357 150 21 a a DET dti-1357 150 22 ge ge PROPN dti-1357 150 23 ni ni PROPN dti-1357 150 24 ta ta PROPN dti-1357 150 25 liu liu PROPN dti-1357 150 26 m m PROPN dti-1357 150 27 g g PROPN dti-1357 150 28 37 37 NUM dti-1357 150 29 m m NOUN dti-1357 150 30 yc yc NOUN dti-1357 150 31 op op NOUN dti-1357 151 1 la la PROPN dti-1357 151 2 sm sm PROPN dti-1357 151 3 a a DET dti-1357 151 4 pu pu PROPN dti-1357 151 5 lm lm X dti-1357 151 6 on on ADP dti-1357 151 7 is be AUX dti-1357 151 8 u u PROPN dti-1357 151 9 a a DET dti-1357 151 10 b b NOUN dti-1357 151 11 c c NOUN dti-1357 151 12 ti ti NOUN dti-1357 151 13 p p NOUN dti-1357 151 14 p p PROPN dti-1357 151 15 or or CCONJ dti-1357 151 16 ph ph ADJ dti-1357 151 17 yr yr NOUN dti-1357 151 18 om om NOUN dti-1357 151 19 on on ADP dti-1357 151 20 as as ADP dti-1357 151 21 g g PROPN dti-1357 151 22 in in ADP dti-1357 151 23 gi gi PROPN dti-1357 151 24 va va PROPN dti-1357 151 25 lis li NOUN dti-1357 151 26 a a DET dti-1357 151 27 tc tc NOUN dti-1357 151 28 c c NOUN dti-1357 151 29 3 3 NUM dti-1357 151 30 32 32 NUM dti-1357 151 31 77 77 NUM dti-1357 151 32 p p X dti-1357 151 33 se se INTJ dti-1357 151 34 ud ud INTJ dti-1357 151 35 om om VERB dti-1357 151 36 on on ADP dti-1357 151 37 as as ADP dti-1357 151 38 a a DET dti-1357 151 39 er er INTJ dti-1357 151 40 ug ug ADP dti-1357 151 41 in in ADP dti-1357 151 42 os os PROPN dti-1357 151 43 a a DET dti-1357 151 44 p p NOUN dti-1357 151 45 a a DET dti-1357 151 46 o o NOUN dti-1357 151 47 1 1 NUM dti-1357 152 1 p p X dti-1357 152 2 se se X dti-1357 152 3 ud ud INTJ dti-1357 152 4 om om VERB dti-1357 152 5 on on ADP dti-1357 152 6 as as ADP dti-1357 152 7 a a DET dti-1357 152 8 er er INTJ dti-1357 152 9 ug ug ADP dti-1357 152 10 in in ADP dti-1357 152 11 os os PROPN dti-1357 152 12 a a DET dti-1357 152 13 u u NOUN dti-1357 153 1 c c PROPN dti-1357 153 2 b b PROPN dti-1357 153 3 p p X dti-1357 153 4 p p X dti-1357 154 1 -p -p PUNCT dti-1357 154 2 a a DET dti-1357 154 3 14 14 NUM dti-1357 154 4 s s NOUN dti-1357 154 5 al al PROPN dti-1357 154 6 m m PROPN dti-1357 154 7 on on ADP dti-1357 154 8 el el PROPN dti-1357 154 9 la la PROPN dti-1357 154 10 e e PROPN dti-1357 154 11 nt not PART dti-1357 154 12 er er INTJ dti-1357 154 13 ic ic PROPN dti-1357 155 1 a a DET dti-1357 155 2 se se X dti-1357 155 3 ro ro PROPN dti-1357 155 4 va va PROPN dti-1357 155 5 r r PROPN dti-1357 155 6 t t PROPN dti-1357 156 1 yp yp INTJ dti-1357 157 1 hi hi INTJ dti-1357 157 2 s s PROPN dti-1357 157 3 al al PROPN dti-1357 157 4 m m PROPN dti-1357 157 5 on on ADP dti-1357 157 6 el el PROPN dti-1357 157 7 la la PROPN dti-1357 157 8 e e PROPN dti-1357 157 9 nt not PART dti-1357 157 10 er er INTJ dti-1357 157 11 ic ic PROPN dti-1357 158 1 a a DET dti-1357 158 2 se se X dti-1357 158 3 ro ro PROPN dti-1357 158 4 va va PROPN dti-1357 158 5 r r PROPN dti-1357 158 6 t t PROPN dti-1357 159 1 yp yp INTJ dti-1357 160 1 hi hi INTJ dti-1357 160 2 t t PROPN dti-1357 161 1 y2 y2 PROPN dti-1357 161 2 s s PROPN dti-1357 161 3 al al PROPN dti-1357 161 4 m m PROPN dti-1357 161 5 on on ADP dti-1357 161 6 el el PROPN dti-1357 161 7 la la PROPN dti-1357 161 8 e e PROPN dti-1357 161 9 nt not PART dti-1357 161 10 er er INTJ dti-1357 161 11 ic ic INTJ dti-1357 161 12 a a DET dti-1357 161 13 s s PROPN dti-1357 161 14 l1 l1 NOUN dti-1357 161 15 34 34 NUM dti-1357 161 16 4 4 NUM dti-1357 161 17 s s NOUN dti-1357 161 18 al al PROPN dti-1357 161 19 m m PROPN dti-1357 161 20 on on ADP dti-1357 161 21 el el PROPN dti-1357 161 22 la la PROPN dti-1357 161 23 e e PROPN dti-1357 161 24 nt not PART dti-1357 161 25 er er INTJ dti-1357 161 26 ic ic PROPN dti-1357 161 27 a a DET dti-1357 161 28 su su NOUN dti-1357 161 29 bs bs PROPN dti-1357 162 1 p. p. PROPN dti-1357 162 2 e e PROPN dti-1357 163 1 nt not PART dti-1357 163 2 er er INTJ dti-1357 163 3 ic ic PROPN dti-1357 163 4 a a DET dti-1357 163 5 st st PROPN dti-1357 163 6 r. r. PROPN dti-1357 163 7 … … PUNCT dti-1357 163 8 s s PART dti-1357 163 9 al al PROPN dti-1357 163 10 m m PROPN dti-1357 163 11 on on ADP dti-1357 163 12 el el PROPN dti-1357 163 13 la la PROPN dti-1357 163 14 ty ty INTJ dti-1357 163 15 ph ph PROPN dti-1357 164 1 i i PRON dti-1357 164 2 m m VERB dti-1357 164 3 ur ur INTJ dti-1357 164 4 iu iu ADP dti-1357 164 5 m m PROPN dti-1357 164 6 l l NOUN dti-1357 164 7 t2 t2 NOUN dti-1357 164 8 s s VERB dti-1357 164 9 he he PRON dti-1357 164 10 w w ADP dti-1357 165 1 an an DET dti-1357 165 2 el el PROPN dti-1357 165 3 la la PROPN dti-1357 165 4 o o PROPN dti-1357 165 5 ne ne X dti-1357 165 6 i i PROPN dti-1357 165 7 d d PROPN dti-1357 165 8 en en X dti-1357 165 9 si si PROPN dti-1357 165 10 s s PART dti-1357 165 11 m m VERB dti-1357 165 12 r r NOUN dti-1357 165 13 -1 -1 X dti-1357 165 14 s s X dti-1357 165 15 ph ph NOUN dti-1357 165 16 in in ADP dti-1357 165 17 go go VERB dti-1357 165 18 m m VERB dti-1357 165 19 on on ADP dti-1357 165 20 as as ADP dti-1357 165 21 w w PROPN dti-1357 165 22 itt itt INTJ dti-1357 166 1 ic ic INTJ dti-1357 166 2 hi hi INTJ dti-1357 167 1 i i INTJ dti-1357 168 1 r r VERB dti-1357 168 2 w w PROPN dti-1357 168 3 1 1 NUM dti-1357 168 4 s s PART dti-1357 168 5 ta ta X dti-1357 168 6 ph ph NOUN dti-1357 168 7 yl yl NOUN dti-1357 168 8 oc oc NOUN dti-1357 168 9 oc oc VERB dti-1357 168 10 cu cu PROPN dti-1357 168 11 s s PART dti-1357 168 12 au au VERB dti-1357 168 13 re re ADP dti-1357 168 14 us us PROPN dti-1357 168 15 n n ADV dti-1357 168 16 31 31 NUM dti-1357 168 17 5 5 NUM dti-1357 168 18 s s NOUN dti-1357 168 19 ta ta X dti-1357 168 20 ph ph NOUN dti-1357 168 21 yl yl NOUN dti-1357 168 22 oc oc NOUN dti-1357 168 23 oc oc VERB dti-1357 168 24 cu cu PROPN dti-1357 168 25 s s PART dti-1357 168 26 au au VERB dti-1357 168 27 re re ADP dti-1357 168 28 us us PROPN dti-1357 168 29 n n PROPN dti-1357 168 30 c c NOUN dti-1357 168 31 tc tc NUM dti-1357 168 32 8 8 NUM dti-1357 168 33 32 32 NUM dti-1357 168 34 5 5 NUM dti-1357 168 35 s s PART dti-1357 168 36 tre tre NOUN dti-1357 168 37 pt pt PROPN dti-1357 168 38 oc oc NOUN dti-1357 168 39 oc oc ADP dti-1357 168 40 cu cu PROPN dti-1357 168 41 s s PART dti-1357 168 42 pn pn PROPN dti-1357 168 43 eu eu PROPN dti-1357 168 44 m m PROPN dti-1357 168 45 on on ADP dti-1357 168 46 ia ia PROPN dti-1357 168 47 e e PROPN dti-1357 168 48 s s PROPN dti-1357 168 49 tre tre PROPN dti-1357 168 50 pt pt PROPN dti-1357 168 51 oc oc NOUN dti-1357 168 52 oc oc ADP dti-1357 168 53 cu cu PROPN dti-1357 168 54 s s PROPN dti-1357 168 55 sa sa PROPN dti-1357 168 56 ng ng PROPN dti-1357 168 57 ui ui PROPN dti-1357 168 58 ni ni PROPN dti-1357 168 59 s s PROPN dti-1357 168 60 v v PROPN dti-1357 168 61 ib ib PROPN dti-1357 168 62 rio rio PROPN dti-1357 168 63 c c PROPN dti-1357 168 64 ho ho PROPN dti-1357 168 65 le le PROPN dti-1357 168 66 ra ra PROPN dti-1357 168 67 e e PROPN dti-1357 168 68 n n PROPN dti-1357 168 69 16 16 NUM dti-1357 168 70 96 96 NUM dti-1357 168 71 1 1 NUM dti-1357 168 72 n n AUX dti-1357 168 73 um um INTJ dti-1357 168 74 be be AUX dti-1357 168 75 r r NOUN dti-1357 168 76 o o NOUN dti-1357 169 1 f f NOUN dti-1357 169 2 h h NOUN dti-1357 169 3 its its PRON dti-1357 169 4 figure figure NOUN dti-1357 169 5 2 2 NUM dti-1357 169 6 . . PUNCT dti-1357 169 7 comparison comparison NOUN dti-1357 169 8 of of ADP dti-1357 169 9 m. m. NOUN dti-1357 169 10 hominis hominis PROPN dti-1357 169 11 genome genome NOUN dti-1357 169 12 against against ADP dti-1357 169 13 deg deg PROPN dti-1357 169 14 . . PUNCT dti-1357 170 1 the the DET dti-1357 170 2 height height NOUN dti-1357 170 3 of of ADP dti-1357 170 4 the the DET dti-1357 170 5 bars bar NOUN dti-1357 170 6 indicates indicate VERB dti-1357 170 7 the the DET dti-1357 170 8 number number NOUN dti-1357 170 9 of of ADP dti-1357 170 10 hits hit NOUN dti-1357 170 11 on on ADP dti-1357 170 12 other other ADJ dti-1357 170 13 genomes genome NOUN dti-1357 170 14 . . PUNCT dti-1357 171 1 http://www.la-press.com http://www.la-press.com X dti-1357 171 2 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1357 171 3 parvege parvege PROPN dti-1357 171 4 et et PROPN dti-1357 171 5 al al PROPN dti-1357 171 6 56 56 NUM dti-1357 171 7 drug drug NOUN dti-1357 171 8 target target NOUN dti-1357 171 9 insights insight VERB dti-1357 171 10 2014:8 2014:8 NUM dti-1357 171 11 table table NOUN dti-1357 171 12 2 2 NUM dti-1357 171 13 . . PUNCT dti-1357 171 14 qualitative qualitative ADJ dti-1357 171 15 characterization characterization NOUN dti-1357 171 16 of of ADP dti-1357 171 17 ∑ ∑ NOUN dti-1357 171 18 list list NOUN dti-1357 171 19 targets target NOUN dti-1357 171 20 . . PUNCT dti-1357 172 1 the the DET dti-1357 172 2 subcellular subcellular ADJ dti-1357 172 3 localizations localization NOUN dti-1357 172 4 are be AUX dti-1357 172 5 based base VERB dti-1357 172 6 on on ADP dti-1357 172 7 the the DET dti-1357 172 8 consensus consensus NOUN dti-1357 172 9 results result NOUN dti-1357 172 10 from from ADP dti-1357 172 11 prediction prediction NOUN dti-1357 172 12 by by ADP dti-1357 172 13 psortb psortb NOUN dti-1357 172 14 , , PUNCT dti-1357 172 15 cello cello NOUN dti-1357 172 16 , , PUNCT dti-1357 172 17 and and CCONJ dti-1357 172 18 topcons topcon NOUN dti-1357 172 19 . . PUNCT dti-1357 173 1 tmh tmh PROPN dti-1357 173 2 is be AUX dti-1357 173 3 transmembrane transmembrane ADJ dti-1357 173 4 helix helix NOUN dti-1357 173 5 predicted predict VERB dti-1357 173 6 by by ADP dti-1357 173 7 tmhmm tmhmm NOUN dti-1357 173 8 . . PUNCT dti-1357 174 1 no no DET dti-1357 174 2 kegg kegg NOUN dti-1357 174 3 i i PROPN dti-1357 174 4 d d PROPN dti-1357 174 5 gene gene NOUN dti-1357 174 6 product product NOUN dti-1357 174 7 definition definition NOUN dti-1357 174 8 subcellular subcellular ADJ dti-1357 174 9 localization localization PROPN dti-1357 174 10 tmh tmh PROPN dti-1357 174 11 broad broad PROPN dti-1357 174 12 spectrum spectrum NOUN dti-1357 174 13 property property NOUN dti-1357 174 14 interactors interactor NOUN dti-1357 174 15 3d 3d PROPN dti-1357 174 16 model model PROPN dti-1357 174 17 druggability druggability NOUN dti-1357 174 18 1 1 NUM dti-1357 174 19 mho_0670 mho_0670 NUM dti-1357 174 20 fructose fructose NOUN dti-1357 174 21 - - PUNCT dti-1357 174 22 bisphosphate bisphosphate NOUN dti-1357 174 23 aldolase aldolase NOUN dti-1357 174 24 cytoplasm cytoplasm NOUN dti-1357 174 25 0 0 NUM dti-1357 175 1 no no PRON dti-1357 175 2 ( ( PUNCT dti-1357 175 3 91 91 NUM dti-1357 175 4 ) ) PUNCT dti-1357 175 5 13 13 NUM dti-1357 176 1 yes yes INTJ dti-1357 176 2 druggable druggable ADJ dti-1357 176 3 2 2 NUM dti-1357 176 4 mho_0100 mho_0100 PROPN dti-1357 176 5 putative putative ADJ dti-1357 176 6 nucleoside nucleoside NOUN dti-1357 176 7 phosphorylase phosphorylase NOUN dti-1357 176 8 cytoplasm cytoplasm NOUN dti-1357 176 9 0 0 NUM dti-1357 177 1 no no PRON dti-1357 177 2 ( ( PUNCT dti-1357 177 3 71 71 NUM dti-1357 177 4 ) ) SYM dti-1357 177 5 4 4 NUM dti-1357 178 1 yes yes INTJ dti-1357 178 2 druggable druggable ADJ dti-1357 178 3 3 3 NUM dti-1357 178 4 mho_0980 mho_0980 NUM dti-1357 178 5 thymidylate thymidylate NOUN dti-1357 178 6 kinase kinase NOUN dti-1357 178 7 cytoplasm cytoplasm PROPN dti-1357 178 8 0 0 PROPN dti-1357 179 1 yes yes INTJ dti-1357 179 2 ( ( PUNCT dti-1357 179 3 102 102 NUM dti-1357 179 4 ) ) PUNCT dti-1357 179 5 10 10 NUM dti-1357 180 1 no no DET dti-1357 180 2 druggable druggable ADJ dti-1357 180 3 4 4 NUM dti-1357 180 4 mho_0990 mho_0990 NOUN dti-1357 180 5 dna dna NOUN dti-1357 180 6 polymerase polymerase NOUN dti-1357 180 7 iii iii X dti-1357 180 8 subunit subunit NOUN dti-1357 180 9 cytoplasm cytoplasm VERB dti-1357 180 10 0 0 PUNCT dti-1357 181 1 no no PRON dti-1357 181 2 ( ( PUNCT dti-1357 181 3 84 84 NUM dti-1357 181 4 ) ) PUNCT dti-1357 181 5 10 10 NUM dti-1357 181 6 no no DET dti-1357 181 7 novel novel ADJ dti-1357 181 8 5 5 NUM dti-1357 181 9 mho_1260 mho_1260 NUM dti-1357 181 10 putative putative ADJ dti-1357 181 11 nicotinate nicotinate ADJ dti-1357 181 12 - - PUNCT dti-1357 181 13 nucleotide nucleotide NOUN dti-1357 181 14 adenylyl adenylyl NOUN dti-1357 181 15 transferase transferase NOUN dti-1357 181 16 cytoplasm cytoplasm NOUN dti-1357 181 17 0 0 PUNCT dti-1357 182 1 no no DET dti-1357 182 2 ( ( PUNCT dti-1357 182 3 98 98 NUM dti-1357 182 4 ) ) SYM dti-1357 182 5 13 13 NUM dti-1357 183 1 yes yes INTJ dti-1357 183 2 druggable druggable ADJ dti-1357 183 3 6 6 NUM dti-1357 183 4 mho_1670 mho_1670 NOUN dti-1357 183 5 cytidylate cytidylate ADJ dti-1357 183 6 kinase kinase PROPN dti-1357 183 7 cytoplasm cytoplasm PROPN dti-1357 183 8 0 0 PROPN dti-1357 184 1 yes yes INTJ dti-1357 184 2 ( ( PUNCT dti-1357 184 3 102 102 NUM dti-1357 184 4 ) ) SYM dti-1357 184 5 8 8 NUM dti-1357 185 1 yes yes INTJ dti-1357 185 2 druggable druggable ADJ dti-1357 185 3 7 7 NUM dti-1357 185 4 mho_2380 mho_2380 NUM dti-1357 185 5 riboflavin riboflavin NOUN dti-1357 185 6 biosynthesis biosynthesis NOUN dti-1357 185 7 protein protein NOUN dti-1357 185 8 membrane membrane NOUN dti-1357 185 9 5 5 NUM dti-1357 185 10 no no NOUN dti-1357 185 11 ( ( PUNCT dti-1357 185 12 44 44 NUM dti-1357 185 13 ) ) PUNCT dti-1357 185 14 12 12 NUM dti-1357 185 15 no no DET dti-1357 185 16 novel novel NOUN dti-1357 185 17 8 8 NUM dti-1357 185 18 mho_2730 mho_2730 NUM dti-1357 185 19 dna dna NOUN dti-1357 185 20 - - PUNCT dti-1357 185 21 directed direct VERB dti-1357 185 22 rna rna NOUN dti-1357 185 23 polymerase polymerase NOUN dti-1357 185 24 subunit subunit NOUN dti-1357 185 25 alpha alpha NOUN dti-1357 185 26 cytoplasm cytoplasm ADJ dti-1357 185 27 0 0 PUNCT dti-1357 186 1 no no PRON dti-1357 186 2 ( ( PUNCT dti-1357 186 3 91 91 NUM dti-1357 186 4 ) ) SYM dti-1357 186 5 2 2 NUM dti-1357 187 1 yes yes INTJ dti-1357 187 2 druggable druggable ADJ dti-1357 187 3 9 9 NUM dti-1357 187 4 mho_0200 mho_0200 PROPN dti-1357 187 5 atp atp NOUN dti-1357 187 6 synthase synthase NOUN dti-1357 187 7 subunit subunit NOUN dti-1357 187 8 a a DET dti-1357 187 9 cytoplasm cytoplasm NOUN dti-1357 187 10 0 0 PUNCT dti-1357 188 1 no no PRON dti-1357 188 2 ( ( PUNCT dti-1357 188 3 89 89 NUM dti-1357 188 4 ) ) PUNCT dti-1357 188 5 50 50 NUM dti-1357 188 6 no no DET dti-1357 188 7 novel novel NOUN dti-1357 188 8 10 10 NUM dti-1357 188 9 mho_0210 mho_0210 PROPN dti-1357 188 10 atp atp NOUN dti-1357 188 11 synthase synthase NOUN dti-1357 188 12 subunit subunit NOUN dti-1357 188 13 c c PROPN dti-1357 188 14 membrane membrane NOUN dti-1357 188 15 2 2 NUM dti-1357 189 1 no no PRON dti-1357 189 2 ( ( PUNCT dti-1357 189 3 42 42 NUM dti-1357 189 4 ) ) PUNCT dti-1357 189 5 13 13 NUM dti-1357 190 1 no no DET dti-1357 190 2 druggable druggable ADJ dti-1357 190 3 11 11 NUM dti-1357 190 4 mho_3350 mho_3350 NOUN dti-1357 190 5 purine purine NOUN dti-1357 190 6 - - PUNCT dti-1357 190 7 nucleoside nucleoside NOUN dti-1357 190 8 phosphorylase phosphorylase NOUN dti-1357 190 9 cytoplasm cytoplasm NOUN dti-1357 190 10 0 0 NUM dti-1357 191 1 no no PRON dti-1357 191 2 ( ( PUNCT dti-1357 191 3 74 74 NUM dti-1357 191 4 ) ) PUNCT dti-1357 191 5 9 9 NUM dti-1357 191 6 yes yes INTJ dti-1357 191 7 druggable druggable ADJ dti-1357 191 8 12 12 NUM dti-1357 191 9 mho_0220 mho_0220 ADP dti-1357 191 10 atp atp NOUN dti-1357 191 11 synthase synthase NOUN dti-1357 191 12 subunit subunit NOUN dti-1357 191 13 b b PROPN dti-1357 191 14 membrane membrane NOUN dti-1357 191 15 1 1 NUM dti-1357 191 16 no no PRON dti-1357 191 17 ( ( PUNCT dti-1357 191 18 34 34 NUM dti-1357 191 19 ) ) PUNCT dti-1357 191 20 11 11 NUM dti-1357 191 21 yes yes NOUN dti-1357 191 22 novel novel VERB dti-1357 191 23 13 13 NUM dti-1357 191 24 mho_3650 mho_3650 PROPN dti-1357 191 25 aspartate aspartate NOUN dti-1357 191 26 — — PUNCT dti-1357 191 27 ammonia ammonia NOUN dti-1357 191 28 ligase ligase NOUN dti-1357 191 29 cytoplasm cytoplasm NOUN dti-1357 191 30 0 0 PUNCT dti-1357 192 1 no no DET dti-1357 192 2 ( ( PUNCT dti-1357 192 3 30 30 NUM dti-1357 192 4 ) ) SYM dti-1357 192 5 2 2 NUM dti-1357 192 6 no no DET dti-1357 192 7 novel novel NOUN dti-1357 192 8 14 14 NUM dti-1357 192 9 mho_3810 mho_3810 NOUN dti-1357 192 10 putative putative ADJ dti-1357 192 11 2,3 2,3 NUM dti-1357 192 12 - - PUNCT dti-1357 192 13 bisphosphoglycerate bisphosphoglycerate ADJ dti-1357 192 14 - - PUNCT dti-1357 192 15 independent independent ADJ dti-1357 192 16 phosphoglycerate phosphoglycerate NOUN dti-1357 192 17 mutase mutase NOUN dti-1357 192 18 cytoplasm cytoplasm NOUN dti-1357 192 19 0 0 NUM dti-1357 193 1 no no DET dti-1357 193 2 ( ( PUNCT dti-1357 193 3 59 59 NUM dti-1357 193 4 ) ) PUNCT dti-1357 193 5 9 9 NUM dti-1357 193 6 yes yes INTJ dti-1357 193 7 druggable druggable ADJ dti-1357 193 8 15 15 NUM dti-1357 193 9 mho_3840 mho_3840 NOUN dti-1357 193 10 acetate acetate PROPN dti-1357 193 11 kinase kinase PROPN dti-1357 193 12 cytoplasm cytoplasm PROPN dti-1357 193 13 0 0 PUNCT dti-1357 194 1 no no DET dti-1357 194 2 ( ( PUNCT dti-1357 194 3 96 96 NUM dti-1357 194 4 ) ) PUNCT dti-1357 194 5 7 7 NUM dti-1357 194 6 yes yes INTJ dti-1357 194 7 druggable druggable ADJ dti-1357 194 8 16 16 NUM dti-1357 194 9 mho_3880 mho_3880 NUM dti-1357 194 10 ribose-5 ribose-5 NUM dti-1357 194 11 - - PUNCT dti-1357 194 12 phosphate phosphate NOUN dti-1357 194 13 isomerase isomerase NOUN dti-1357 194 14 cytoplasm cytoplasm NOUN dti-1357 194 15 0 0 NUM dti-1357 195 1 no no DET dti-1357 195 2 ( ( PUNCT dti-1357 195 3 76 76 NUM dti-1357 195 4 ) ) PUNCT dti-1357 195 5 9 9 NUM dti-1357 195 6 yes yes INTJ dti-1357 195 7 druggable druggable ADJ dti-1357 195 8 17 17 NUM dti-1357 195 9 mho_4030 mho_4030 NOUN dti-1357 195 10 thiamine thiamine NOUN dti-1357 195 11 biosynthesis biosynthesis VERB dti-1357 195 12 protein protein NOUN dti-1357 195 13 cytoplasm cytoplasm NOUN dti-1357 195 14 0 0 PUNCT dti-1357 196 1 no no PRON dti-1357 196 2 ( ( PUNCT dti-1357 196 3 80 80 NUM dti-1357 196 4 ) ) SYM dti-1357 196 5 2 2 NUM dti-1357 196 6 no no DET dti-1357 196 7 novel novel NOUN dti-1357 196 8 18 18 NUM dti-1357 196 9 mho_4130 mho_4130 PROPN dti-1357 196 10 dna dna PROPN dti-1357 196 11 polymerase polymerase NOUN dti-1357 197 1 i i PRON dti-1357 197 2 cytoplasm cytoplasm VERB dti-1357 197 3 0 0 NUM dti-1357 198 1 yes yes INTJ dti-1357 198 2 ( ( PUNCT dti-1357 198 3 127 127 NUM dti-1357 198 4 ) ) PUNCT dti-1357 198 5 13 13 NUM dti-1357 199 1 no no DET dti-1357 199 2 druggable druggable ADJ dti-1357 199 3 19 19 NUM dti-1357 199 4 mho_4370 mho_4370 NUM dti-1357 199 5 putative putative ADJ dti-1357 199 6 glycerol-3 glycerol-3 NOUN dti-1357 199 7 - - PUNCT dti-1357 199 8 phosphate phosphate NOUN dti-1357 199 9 acyltransferase acyltransferase NOUN dti-1357 199 10 membrane membrane NOUN dti-1357 199 11 6 6 NUM dti-1357 199 12 no no PRON dti-1357 199 13 ( ( PUNCT dti-1357 199 14 76 76 NUM dti-1357 199 15 ) ) PUNCT dti-1357 199 16 3 3 NUM dti-1357 199 17 no no DET dti-1357 199 18 novel novel NOUN dti-1357 199 19 20 20 NUM dti-1357 199 20 mho_4600 mho_4600 NUM dti-1357 199 21 uridylate uridylate ADJ dti-1357 199 22 kinase kinase NOUN dti-1357 199 23 cytoplasm cytoplasm PROPN dti-1357 199 24 0 0 PROPN dti-1357 200 1 yes yes INTJ dti-1357 200 2 ( ( PUNCT dti-1357 200 3 111 111 NUM dti-1357 200 4 ) ) PUNCT dti-1357 200 5 6 6 NUM dti-1357 200 6 yes yes NOUN dti-1357 200 7 novel novel NOUN dti-1357 200 8 21 21 NUM dti-1357 200 9 mho_4680 mho_4680 NUM dti-1357 200 10 fatty fatty NOUN dti-1357 200 11 acid acid NOUN dti-1357 200 12 / / SYM dti-1357 200 13 phospholipid phospholipid NOUN dti-1357 200 14 synthesis synthesis NOUN dti-1357 200 15 protein protein NOUN dti-1357 200 16 cytoplasm cytoplasm ADJ dti-1357 200 17 0 0 PUNCT dti-1357 201 1 no no PRON dti-1357 201 2 ( ( PUNCT dti-1357 201 3 82 82 NUM dti-1357 201 4 ) ) PUNCT dti-1357 201 5 9 9 NUM dti-1357 201 6 yes yes NOUN dti-1357 201 7 novel novel NOUN dti-1357 201 8 22 22 NUM dti-1357 201 9 mho_2040 mho_2040 NUM dti-1357 201 10 putative putative ADJ dti-1357 201 11 dna dna PROPN dti-1357 201 12 polymerase polymerase PROPN dti-1357 201 13 iii iii PROPN dti-1357 201 14 , , PUNCT dti-1357 201 15 delta delta NOUN dti-1357 201 16 subunit subunit NOUN dti-1357 201 17 cytoplasm cytoplasm VERB dti-1357 201 18 0 0 PUNCT dti-1357 202 1 no no DET dti-1357 202 2 ( ( PUNCT dti-1357 202 3 41 41 NUM dti-1357 202 4 ) ) PUNCT dti-1357 202 5 6 6 NUM dti-1357 202 6 no no DET dti-1357 202 7 novel novel NOUN dti-1357 202 8 23 23 NUM dti-1357 202 9 mho_0850 mho_0850 NOUN dti-1357 202 10 uvrabc uvrabc ADJ dti-1357 202 11 system system NOUN dti-1357 202 12 protein protein NOUN dti-1357 202 13 c c PROPN dti-1357 202 14 cytoplasm cytoplasm NOUN dti-1357 202 15 0 0 NUM dti-1357 203 1 yes yes INTJ dti-1357 203 2 ( ( PUNCT dti-1357 203 3 102 102 NUM dti-1357 203 4 ) ) PUNCT dti-1357 203 5 7 7 NUM dti-1357 203 6 no no DET dti-1357 203 7 novel novel ADJ dti-1357 203 8 24 24 NUM dti-1357 203 9 mho_0030 mho_0030 PROPN dti-1357 203 10 50s 50 NOUN dti-1357 203 11 ribosomal ribosomal NOUN dti-1357 203 12 protein protein NOUN dti-1357 203 13 l34 l34 VERB dti-1357 203 14 cytoplasm cytoplasm ADJ dti-1357 203 15 0 0 PUNCT dti-1357 204 1 no no DET dti-1357 204 2 ( ( PUNCT dti-1357 204 3 64 64 NUM dti-1357 204 4 ) ) PUNCT dti-1357 204 5 50 50 NUM dti-1357 204 6 no no DET dti-1357 204 7 novel novel NOUN dti-1357 204 8 25 25 NUM dti-1357 204 9 mho_0880 mho_0880 PROPN dti-1357 204 10 50s 50 NOUN dti-1357 204 11 ribosomal ribosomal NOUN dti-1357 204 12 protein protein NOUN dti-1357 204 13 l1 l1 PROPN dti-1357 204 14 cytoplasm cytoplasm NOUN dti-1357 204 15 0 0 PUNCT dti-1357 204 16 no no DET dti-1357 204 17 ( ( PUNCT dti-1357 204 18 97 97 NUM dti-1357 204 19 ) ) PUNCT dti-1357 204 20 50 50 NUM dti-1357 204 21 no no DET dti-1357 204 22 novel novel NOUN dti-1357 204 23 26 26 NUM dti-1357 204 24 mho_1010 mho_1010 NUM dti-1357 204 25 30s 30 NOUN dti-1357 204 26 ribosomal ribosomal NOUN dti-1357 204 27 protein protein NOUN dti-1357 204 28 s20 s20 VERB dti-1357 204 29 cytoplasm cytoplasm NOUN dti-1357 204 30 0 0 PUNCT dti-1357 205 1 no no PRON dti-1357 205 2 ( ( PUNCT dti-1357 205 3 72 72 NUM dti-1357 205 4 ) ) PUNCT dti-1357 205 5 0 0 NUM dti-1357 206 1 no no DET dti-1357 206 2 novel novel NOUN dti-1357 206 3 27 27 NUM dti-1357 206 4 mho_1120 mho_1120 PROPN dti-1357 206 5 30s 30 NOUN dti-1357 206 6 ribosomal ribosomal NOUN dti-1357 206 7 protein protein NOUN dti-1357 206 8 s6 s6 PROPN dti-1357 206 9 cytoplasm cytoplasm PROPN dti-1357 206 10 0 0 PUNCT dti-1357 206 11 no no PRON dti-1357 206 12 ( ( PUNCT dti-1357 206 13 59 59 NUM dti-1357 206 14 ) ) PUNCT dti-1357 206 15 32 32 NUM dti-1357 206 16 no no DET dti-1357 206 17 novel novel NOUN dti-1357 206 18 28 28 NUM dti-1357 206 19 mho_1280 mho_1280 PROPN dti-1357 206 20 50s 50 NOUN dti-1357 206 21 ribosomal ribosomal NOUN dti-1357 206 22 protein protein NOUN dti-1357 206 23 l35 l35 NOUN dti-1357 206 24 cytoplasm cytoplasm NOUN dti-1357 206 25 0 0 PUNCT dti-1357 206 26 no no PRON dti-1357 206 27 ( ( PUNCT dti-1357 206 28 72 72 NUM dti-1357 206 29 ) ) PUNCT dti-1357 206 30 31 31 NUM dti-1357 206 31 no no DET dti-1357 206 32 novel novel NOUN dti-1357 206 33 29 29 NUM dti-1357 206 34 mho_1180 mho_1180 NUM dti-1357 206 35 phenylalanyl phenylalanyl PROPN dti-1357 206 36 - - PUNCT dti-1357 206 37 trna trna ADJ dti-1357 206 38 synthetase synthetase NOUN dti-1357 206 39 subunit subunit NOUN dti-1357 206 40 beta beta NOUN dti-1357 206 41 cytoplasm cytoplasm NOUN dti-1357 206 42 0 0 PUNCT dti-1357 206 43 yes yes INTJ dti-1357 206 44 ( ( PUNCT dti-1357 206 45 116 116 NUM dti-1357 206 46 ) ) PUNCT dti-1357 206 47 32 32 NUM dti-1357 206 48 no no PRON dti-1357 206 49 druggable druggable ADJ dti-1357 206 50 30 30 NUM dti-1357 206 51 mho_0050 mho_0050 NUM dti-1357 206 52 dna dna PROPN dti-1357 206 53 polymerase polymerase NOUN dti-1357 206 54 iii iii X dti-1357 206 55 subunit subunit NOUN dti-1357 206 56 beta beta NOUN dti-1357 206 57 cytoplasm cytoplasm NOUN dti-1357 206 58 0 0 PUNCT dti-1357 207 1 yes yes INTJ dti-1357 207 2 ( ( PUNCT dti-1357 207 3 101 101 NUM dti-1357 207 4 ) ) PUNCT dti-1357 207 5 24 24 NUM dti-1357 207 6 yes yes INTJ dti-1357 207 7 druggable druggable ADJ dti-1357 207 8 31 31 NUM dti-1357 207 9 mho_1520 mho_1520 NUM dti-1357 207 10 oligopeptide oligopeptide NOUN dti-1357 207 11 transport transport NOUN dti-1357 207 12 system system NOUN dti-1357 207 13 permease permease NOUN dti-1357 207 14 protein protein NOUN dti-1357 207 15 membrane membrane NOUN dti-1357 207 16 6 6 NUM dti-1357 207 17 yes yes INTJ dti-1357 207 18 ( ( PUNCT dti-1357 207 19 119 119 NUM dti-1357 207 20 ) ) PUNCT dti-1357 207 21 5 5 NUM dti-1357 207 22 no no DET dti-1357 207 23 novel novel NOUN dti-1357 207 24 32 32 NUM dti-1357 207 25 mho_1990 mho_1990 NUM dti-1357 207 26 cobalt cobalt NOUN dti-1357 207 27 abc abc PROPN dti-1357 207 28 transporter transporter NOUN dti-1357 207 29 permease permease NOUN dti-1357 207 30 protein protein NOUN dti-1357 207 31 membrane membrane NOUN dti-1357 207 32 5 5 NUM dti-1357 207 33 no no NOUN dti-1357 207 34 ( ( PUNCT dti-1357 207 35 57 57 NUM dti-1357 207 36 ) ) PUNCT dti-1357 207 37 3 3 NUM dti-1357 207 38 no no DET dti-1357 207 39 novel novel NOUN dti-1357 207 40 33 33 NUM dti-1357 207 41 mho_0970 mho_0970 PROPN dti-1357 207 42 recombination recombination NOUN dti-1357 207 43 protein protein NOUN dti-1357 207 44 recr recr VERB dti-1357 207 45 cytoplasm cytoplasm NOUN dti-1357 207 46 0 0 NUM dti-1357 208 1 yes yes INTJ dti-1357 208 2 ( ( PUNCT dti-1357 208 3 104 104 NUM dti-1357 208 4 ) ) PUNCT dti-1357 208 5 10 10 NUM dti-1357 209 1 no no DET dti-1357 209 2 novel novel NOUN dti-1357 209 3 34 34 NUM dti-1357 209 4 mho_1840 mho_1840 NUM dti-1357 209 5 holliday holliday PROPN dti-1357 209 6 junction junction PROPN dti-1357 209 7 dna dna PROPN dti-1357 209 8 helicase helicase NOUN dti-1357 209 9 ruva ruva ADV dti-1357 209 10 cytoplasm cytoplasm PROPN dti-1357 209 11 0 0 PUNCT dti-1357 210 1 no no PRON dti-1357 210 2 ( ( PUNCT dti-1357 210 3 93 93 NUM dti-1357 210 4 ) ) PUNCT dti-1357 210 5 7 7 NUM dti-1357 210 6 no no DET dti-1357 210 7 novel novel NOUN dti-1357 210 8 35 35 NUM dti-1357 210 9 mho_1130 mho_1130 NUM dti-1357 210 10 single single ADJ dti-1357 210 11 - - PUNCT dti-1357 210 12 strand strand NOUN dti-1357 210 13 binding bind VERB dti-1357 210 14 protein protein NOUN dti-1357 210 15 cytoplasm cytoplasm NOUN dti-1357 210 16 0 0 PUNCT dti-1357 211 1 no no PRON dti-1357 211 2 ( ( PUNCT dti-1357 211 3 87 87 NUM dti-1357 211 4 ) ) PUNCT dti-1357 211 5 4 4 NUM dti-1357 211 6 no no DET dti-1357 211 7 novel novel NOUN dti-1357 211 8 http://www.la-press.com http://www.la-press.com X dti-1357 211 9 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1357 211 10 identification identification NOUN dti-1357 211 11 of of ADP dti-1357 211 12 therapeutic therapeutic ADJ dti-1357 211 13 targets target NOUN dti-1357 211 14 in in ADP dti-1357 211 15 mycoplasma mycoplasma NOUN dti-1357 211 16 hominis hominis X dti-1357 211 17 57drug 57drug NUM dti-1357 211 18 target target NOUN dti-1357 211 19 insights insight VERB dti-1357 211 20 2014:8 2014:8 NUM dti-1357 211 21 table table NOUN dti-1357 211 22 2 2 NUM dti-1357 211 23 . . PUNCT dti-1357 212 1 ( ( PUNCT dti-1357 212 2 continued continue VERB dti-1357 212 3 ) ) PUNCT dti-1357 212 4 no no DET dti-1357 212 5 kegg kegg NOUN dti-1357 212 6 i i PROPN dti-1357 212 7 d d PROPN dti-1357 212 8 gene gene NOUN dti-1357 212 9 product product NOUN dti-1357 212 10 definition definition NOUN dti-1357 212 11 subcellular subcellular ADJ dti-1357 212 12 localization localization PROPN dti-1357 212 13 tmh tmh PROPN dti-1357 212 14 broad broad PROPN dti-1357 212 15 spectrum spectrum NOUN dti-1357 212 16 property property NOUN dti-1357 212 17 interactors interactor NOUN dti-1357 212 18 3d 3d PROPN dti-1357 212 19 model model PROPN dti-1357 212 20 druggability druggability NOUN dti-1357 212 21 36 36 NUM dti-1357 212 22 mho_2160 mho_2160 NUM dti-1357 212 23 dna dna PROPN dti-1357 212 24 primase primase VERB dti-1357 212 25 cytoplasm cytoplasm NOUN dti-1357 212 26 0 0 PUNCT dti-1357 213 1 yes yes INTJ dti-1357 213 2 ( ( PUNCT dti-1357 213 3 129 129 NUM dti-1357 213 4 ) ) PUNCT dti-1357 213 5 8 8 NUM dti-1357 213 6 no no DET dti-1357 213 7 novel novel NOUN dti-1357 213 8 37 37 NUM dti-1357 213 9 mho_3910 mho_3910 NUM dti-1357 213 10 replicative replicative ADJ dti-1357 213 11 dna dna PROPN dti-1357 213 12 helicase helicase NOUN dti-1357 213 13 cytoplasm cytoplasm NOUN dti-1357 213 14 0 0 NUM dti-1357 214 1 yes yes INTJ dti-1357 214 2 ( ( PUNCT dti-1357 214 3 115 115 NUM dti-1357 214 4 ) ) PUNCT dti-1357 214 5 14 14 NUM dti-1357 215 1 yes yes INTJ dti-1357 215 2 novel novel VERB dti-1357 215 3 38 38 NUM dti-1357 215 4 mho_3690 mho_3690 NUM dti-1357 215 5 putative putative ADJ dti-1357 215 6 ribonuclease ribonuclease NOUN dti-1357 215 7 j j PROPN dti-1357 215 8 cytoplasm cytoplasm NOUN dti-1357 215 9 0 0 SYM dti-1357 216 1 no no PRON dti-1357 216 2 ( ( PUNCT dti-1357 216 3 75 75 NUM dti-1357 216 4 ) ) SYM dti-1357 216 5 1 1 NUM dti-1357 216 6 no no DET dti-1357 216 7 novel novel NOUN dti-1357 216 8 39 39 NUM dti-1357 216 9 mho_4170 mho_4170 NOUN dti-1357 216 10 phosphopentomutase phosphopentomutase NOUN dti-1357 216 11 cytoplasm cytoplasm NOUN dti-1357 216 12 0 0 NUM dti-1357 217 1 no no PRON dti-1357 217 2 ( ( PUNCT dti-1357 217 3 49 49 NUM dti-1357 217 4 ) ) PUNCT dti-1357 217 5 6 6 NUM dti-1357 217 6 yes yes NOUN dti-1357 217 7 novel novel NOUN dti-1357 217 8 40 40 NUM dti-1357 217 9 mho_0010 mho_0010 PROPN dti-1357 217 10 putative putative ADJ dti-1357 217 11 membrane membrane NOUN dti-1357 217 12 insertase insertase NOUN dti-1357 217 13 oxa1 oxa1 PROPN dti-1357 217 14 / / SYM dti-1357 217 15 alb3 alb3 PROPN dti-1357 217 16 / / SYM dti-1357 217 17 yidc yidc PROPN dti-1357 217 18 membrane membrane NOUN dti-1357 217 19 6 6 NUM dti-1357 218 1 no no DET dti-1357 218 2 ( ( PUNCT dti-1357 218 3 96 96 NUM dti-1357 218 4 ) ) PUNCT dti-1357 218 5 4 4 NUM dti-1357 218 6 no no DET dti-1357 218 7 novel novel NOUN dti-1357 218 8 41 41 NUM dti-1357 218 9 mho_1860 mho_1860 NOUN dti-1357 218 10 protein protein NOUN dti-1357 218 11 - - PUNCT dti-1357 218 12 export export NOUN dti-1357 218 13 membrane membrane NOUN dti-1357 218 14 protein protein NOUN dti-1357 218 15 membrane membrane NOUN dti-1357 218 16 12 12 NUM dti-1357 218 17 no no INTJ dti-1357 218 18 ( ( PUNCT dti-1357 218 19 07 07 NUM dti-1357 218 20 ) ) PUNCT dti-1357 218 21 6 6 NUM dti-1357 218 22 no no DET dti-1357 218 23 novel novel NOUN dti-1357 218 24 42 42 NUM dti-1357 218 25 mho_2790 mho_2790 NUM dti-1357 218 26 preprotein preprotein ADJ dti-1357 218 27 translocase translocase NOUN dti-1357 218 28 secy secy NOUN dti-1357 218 29 subunit subunit NOUN dti-1357 218 30 membrane membrane NOUN dti-1357 218 31 10 10 NUM dti-1357 218 32 yes yes INTJ dti-1357 218 33 ( ( PUNCT dti-1357 218 34 104 104 NUM dti-1357 218 35 ) ) PUNCT dti-1357 218 36 49 49 NUM dti-1357 218 37 no no DET dti-1357 218 38 novel novel NOUN dti-1357 218 39 43 43 NUM dti-1357 218 40 mho_4440 mho_4440 PROPN dti-1357 218 41 not not PART dti-1357 218 42 predicted predict VERB dti-1357 218 43 membrane membrane NOUN dti-1357 218 44 1 1 NUM dti-1357 218 45 no no PRON dti-1357 218 46 ( ( PUNCT dti-1357 218 47 06 06 NUM dti-1357 218 48 ) ) PUNCT dti-1357 218 49 6 6 NUM dti-1357 219 1 no no DET dti-1357 219 2 novel novel NOUN dti-1357 219 3 44 44 NUM dti-1357 219 4 mho_4460 mho_4460 NUM dti-1357 219 5 spermidine spermidine NOUN dti-1357 219 6 / / SYM dti-1357 219 7 putrescine putrescine NOUN dti-1357 219 8 abc abc PROPN dti-1357 219 9 transporter transporter NOUN dti-1357 219 10 permease permease NOUN dti-1357 219 11 membrane membrane NOUN dti-1357 219 12 6 6 NUM dti-1357 219 13 no no NOUN dti-1357 219 14 ( ( PUNCT dti-1357 219 15 97 97 NUM dti-1357 219 16 ) ) PUNCT dti-1357 219 17 6 6 NUM dti-1357 219 18 no no DET dti-1357 219 19 novel novel NOUN dti-1357 219 20 45 45 NUM dti-1357 219 21 mho_4470 mho_4470 PROPN dti-1357 219 22 spermidine spermidine NOUN dti-1357 219 23 / / SYM dti-1357 219 24 putrescine putrescine NOUN dti-1357 219 25 abc abc PROPN dti-1357 219 26 transporter transporter NOUN dti-1357 219 27 permease permease NOUN dti-1357 219 28 membrane membrane NOUN dti-1357 219 29 6 6 NUM dti-1357 219 30 no no NOUN dti-1357 219 31 ( ( PUNCT dti-1357 219 32 68 68 NUM dti-1357 219 33 ) ) PUNCT dti-1357 219 34 7 7 NUM dti-1357 219 35 no no DET dti-1357 219 36 novel novel NOUN dti-1357 219 37 46 46 NUM dti-1357 219 38 mho_4480 mho_4480 NUM dti-1357 219 39 not not PART dti-1357 219 40 predicted predict VERB dti-1357 219 41 membrane membrane NOUN dti-1357 219 42 1 1 NUM dti-1357 219 43 no no PRON dti-1357 219 44 ( ( PUNCT dti-1357 219 45 0 0 NUM dti-1357 219 46 ) ) PUNCT dti-1357 219 47 4 4 NUM dti-1357 219 48 no no DET dti-1357 219 49 novel novel NOUN dti-1357 219 50 47 47 NUM dti-1357 219 51 mho_2610 mho_2610 NUM dti-1357 219 52 50s 50 NOUN dti-1357 219 53 ribosomal ribosomal NOUN dti-1357 219 54 protein protein NOUN dti-1357 219 55 l19 l19 NOUN dti-1357 219 56 cytoplasm cytoplasm NOUN dti-1357 219 57 0 0 PUNCT dti-1357 220 1 no no PRON dti-1357 220 2 ( ( PUNCT dti-1357 220 3 77 77 NUM dti-1357 220 4 ) ) PUNCT dti-1357 220 5 50 50 NUM dti-1357 220 6 no no DET dti-1357 220 7 novel novel NOUN dti-1357 220 8 48 48 NUM dti-1357 220 9 mho_2660 mho_2660 NUM dti-1357 220 10 50s 50 NOUN dti-1357 220 11 ribosomal ribosomal NOUN dti-1357 220 12 protein protein NOUN dti-1357 220 13 l21 l21 NOUN dti-1357 220 14 cytoplasm cytoplasm NOUN dti-1357 220 15 0 0 NUM dti-1357 221 1 no no PRON dti-1357 221 2 ( ( PUNCT dti-1357 221 3 72 72 NUM dti-1357 221 4 ) ) PUNCT dti-1357 221 5 50 50 NUM dti-1357 221 6 no no DET dti-1357 221 7 novel novel NOUN dti-1357 221 8 49 49 NUM dti-1357 221 9 mho_2700 mho_2700 NOUN dti-1357 221 10 50s 50 NOUN dti-1357 221 11 ribosomal ribosomal NOUN dti-1357 221 12 protein protein NOUN dti-1357 221 13 l10 l10 NOUN dti-1357 221 14 cytoplasm cytoplasm VERB dti-1357 221 15 0 0 PUNCT dti-1357 222 1 no no PRON dti-1357 222 2 ( ( PUNCT dti-1357 222 3 70 70 NUM dti-1357 222 4 ) ) PUNCT dti-1357 222 5 43 43 NUM dti-1357 223 1 no no DET dti-1357 223 2 druggable druggable ADJ dti-1357 223 3 50 50 NUM dti-1357 223 4 mho_2710 mho_2710 PROPN dti-1357 223 5 50s 50 NOUN dti-1357 223 6 ribosomal ribosomal NOUN dti-1357 223 7 protein protein NOUN dti-1357 223 8 l32 l32 NOUN dti-1357 223 9 cytoplasm cytoplasm NOUN dti-1357 223 10 0 0 NUM dti-1357 224 1 no no PRON dti-1357 224 2 ( ( PUNCT dti-1357 224 3 44 44 NUM dti-1357 224 4 ) ) PUNCT dti-1357 224 5 34 34 NUM dti-1357 225 1 no no DET dti-1357 225 2 druggable druggable ADJ dti-1357 225 3 51 51 NUM dti-1357 225 4 mho_2820 mho_2820 NOUN dti-1357 225 5 50s 50 NOUN dti-1357 225 6 ribosomal ribosomal NOUN dti-1357 225 7 protein protein NOUN dti-1357 225 8 l18 l18 NOUN dti-1357 225 9 membrane membrane NOUN dti-1357 225 10 0 0 PUNCT dti-1357 226 1 no no PRON dti-1357 226 2 ( ( PUNCT dti-1357 226 3 85 85 NUM dti-1357 226 4 ) ) PUNCT dti-1357 226 5 50 50 NUM dti-1357 226 6 no no DET dti-1357 226 7 novel novel NOUN dti-1357 226 8 52 52 NUM dti-1357 226 9 mho_2830 mho_2830 PROPN dti-1357 226 10 50s 50 NOUN dti-1357 226 11 ribosomal ribosomal NOUN dti-1357 226 12 protein protein NOUN dti-1357 226 13 l6 l6 ADJ dti-1357 226 14 cytoplasm cytoplasm NOUN dti-1357 226 15 0 0 SYM dti-1357 227 1 no no PRON dti-1357 227 2 ( ( PUNCT dti-1357 227 3 90 90 NUM dti-1357 227 4 ) ) PUNCT dti-1357 227 5 50 50 NUM dti-1357 227 6 no no DET dti-1357 227 7 novel novel NOUN dti-1357 227 8 53 53 NUM dti-1357 227 9 mho_2870 mho_2870 NOUN dti-1357 227 10 50s 50 NOUN dti-1357 227 11 ribosomal ribosomal NOUN dti-1357 227 12 protein protein NOUN dti-1357 227 13 l24 l24 NUM dti-1357 227 14 cytoplasm cytoplasm NOUN dti-1357 227 15 0 0 PUNCT dti-1357 228 1 no no PRON dti-1357 228 2 ( ( PUNCT dti-1357 228 3 76 76 NUM dti-1357 228 4 ) ) PUNCT dti-1357 228 5 50 50 NUM dti-1357 228 6 no no DET dti-1357 228 7 novel novel NOUN dti-1357 228 8 54 54 NUM dti-1357 228 9 mho_2900 mho_2900 PROPN dti-1357 228 10 50s 50 NOUN dti-1357 228 11 ribosomal ribosomal NOUN dti-1357 228 12 protein protein NOUN dti-1357 228 13 l29 l29 VERB dti-1357 228 14 cytoplasm cytoplasm NOUN dti-1357 228 15 0 0 PUNCT dti-1357 229 1 no no DET dti-1357 229 2 ( ( PUNCT dti-1357 229 3 79 79 NUM dti-1357 229 4 ) ) PUNCT dti-1357 229 5 50 50 NUM dti-1357 229 6 no no DET dti-1357 229 7 novel novel NOUN dti-1357 229 8 55 55 NUM dti-1357 229 9 mho_3020 mho_3020 NOUN dti-1357 229 10 50s 50 NOUN dti-1357 229 11 ribosomal ribosomal NOUN dti-1357 229 12 protein protein NOUN dti-1357 229 13 l31 l31 VERB dti-1357 229 14 cytoplasm cytoplasm NOUN dti-1357 229 15 0 0 PUNCT dti-1357 230 1 no no PRON dti-1357 230 2 ( ( PUNCT dti-1357 230 3 78 78 NUM dti-1357 230 4 ) ) PUNCT dti-1357 230 5 50 50 NUM dti-1357 230 6 no no DET dti-1357 230 7 novel novel NOUN dti-1357 230 8 56 56 NUM dti-1357 230 9 mho_3920 mho_3920 NOUN dti-1357 230 10 50s 50 NOUN dti-1357 230 11 ribosomal ribosomal NOUN dti-1357 230 12 protein protein NOUN dti-1357 230 13 l9 l9 NOUN dti-1357 230 14 cytoplasm cytoplasm PROPN dti-1357 230 15 0 0 SYM dti-1357 231 1 no no DET dti-1357 231 2 ( ( PUNCT dti-1357 231 3 71 71 NUM dti-1357 231 4 ) ) PUNCT dti-1357 231 5 50 50 NUM dti-1357 231 6 no no DET dti-1357 231 7 novel novel NOUN dti-1357 231 8 57 57 NUM dti-1357 231 9 mho_0630 mho_0630 PROPN dti-1357 231 10 carbamate carbamate PROPN dti-1357 231 11 kinase kinase PROPN dti-1357 231 12 cytoplasm cytoplasm PROPN dti-1357 231 13 0 0 PUNCT dti-1357 232 1 no no DET dti-1357 232 2 ( ( PUNCT dti-1357 232 3 48 48 NUM dti-1357 232 4 ) ) PUNCT dti-1357 232 5 3 3 NUM dti-1357 232 6 yes yes NOUN dti-1357 232 7 novel novel NOUN dti-1357 232 8 tmhmm tmhmm NOUN dti-1357 232 9 predicted predict VERB dti-1357 232 10 the the DET dti-1357 232 11 number number NOUN dti-1357 232 12 of of ADP dti-1357 232 13 transmembrane transmembrane ADJ dti-1357 232 14 helixes helix NOUN dti-1357 232 15 ( ( PUNCT dti-1357 232 16 tmh tmh PROPN dti-1357 232 17 ) ) PUNCT dti-1357 232 18 in in ADP dti-1357 232 19 membrane membrane NOUN dti-1357 232 20 proteins protein NOUN dti-1357 232 21 . . PUNCT dti-1357 233 1 biological biological ADJ dti-1357 233 2 functions function NOUN dti-1357 233 3 were be AUX dti-1357 233 4 assigned assign VERB dti-1357 233 5 to to ADP dti-1357 233 6 seven seven NUM dti-1357 233 7 hypothetical hypothetical ADJ dti-1357 233 8 proteins protein NOUN dti-1357 233 9 . . PUNCT dti-1357 234 1 nine nine NUM dti-1357 234 2 proteins protein NOUN dti-1357 234 3 of of ADP dti-1357 234 4 the the DET dti-1357 234 5 ∑ ∑ PUNCT dti-1357 234 6 list list NOUN dti-1357 234 7 with with ADP dti-1357 234 8 kegg kegg PROPN dti-1357 234 9 i i PROPN dti-1357 234 10 d d PROPN dti-1357 234 11 mho_0100 mho_0100 PROPN dti-1357 234 12 , , PUNCT dti-1357 234 13 mho_1260 mho_1260 NUM dti-1357 234 14 , , PUNCT dti-1357 234 15 mho_3810 mho_3810 NUM dti-1357 234 16 , , PUNCT dti-1357 234 17 mho_4370 mho_4370 PROPN dti-1357 234 18 , , PUNCT dti-1357 234 19 mho_2040 mho_2040 PROPN dti-1357 234 20 , , PUNCT dti-1357 234 21 mho_3690 mho_3690 NUM dti-1357 234 22 , , PUNCT dti-1357 234 23 mho_0010 mho_0010 PROPN dti-1357 234 24 , , PUNCT dti-1357 234 25 mho_4440 mho_4440 PROPN dti-1357 234 26 , , PUNCT dti-1357 234 27 and and CCONJ dti-1357 234 28 mho_4480 mho_4480 PROPN dti-1357 234 29 were be AUX dti-1357 234 30 hypothetical hypothetical ADJ dti-1357 234 31 . . PUNCT dti-1357 235 1 seven seven NUM dti-1357 235 2 of of ADP dti-1357 235 3 them they PRON dti-1357 235 4 could could AUX dti-1357 235 5 be be AUX dti-1357 235 6 annotated annotate VERB dti-1357 235 7 using use VERB dti-1357 235 8 the the DET dti-1357 235 9 interpro interpro ADJ dti-1357 235 10 online online ADJ dti-1357 235 11 server server NOUN dti-1357 235 12 ( ( PUNCT dti-1357 235 13 table table NOUN dti-1357 235 14 2 2 NUM dti-1357 235 15 ) ) PUNCT dti-1357 235 16 . . PUNCT dti-1357 236 1 mho_0100 mho_0100 PROPN dti-1357 236 2 was be AUX dti-1357 236 3 predicted predict VERB dti-1357 236 4 to to PART dti-1357 236 5 have have VERB dti-1357 236 6 a a DET dti-1357 236 7 nucleoside nucleoside ADJ dti-1357 236 8 phosphorylase phosphorylase NOUN dti-1357 236 9 domain domain NOUN dti-1357 236 10 with with ADP dti-1357 236 11 a a DET dti-1357 236 12 catalytic catalytic ADJ dti-1357 236 13 role role NOUN dti-1357 236 14 in in ADP dti-1357 236 15 the the DET dti-1357 236 16 nucleoside nucleoside NOUN dti-1357 236 17 metabolic metabolic NOUN dti-1357 236 18 process process NOUN dti-1357 236 19 . . PUNCT dti-1357 237 1 mho_1260 mho_1260 NUM dti-1357 237 2 is be AUX dti-1357 237 3 a a DET dti-1357 237 4 probable probable ADJ dti-1357 237 5 member member NOUN dti-1357 237 6 of of ADP dti-1357 237 7 the the DET dti-1357 237 8 nicotinate nicotinate NOUN dti-1357 237 9 - - PUNCT dti-1357 237 10 nucleotide nucleotide NOUN dti-1357 237 11 adenylyltransferase adenylyltransferase ADJ dti-1357 237 12 protein protein NOUN dti-1357 237 13 family family NOUN dti-1357 237 14 having have VERB dti-1357 237 15 a a DET dti-1357 237 16 role role NOUN dti-1357 237 17 in in ADP dti-1357 237 18 the the DET dti-1357 237 19 nad nad ADJ dti-1357 237 20 biosynthetic biosynthetic ADJ dti-1357 237 21 pathway pathway NOUN dti-1357 237 22 . . PUNCT dti-1357 238 1 mho_3810 mho_3810 PUNCT dti-1357 238 2 probably probably ADV dti-1357 238 3 plays play VERB dti-1357 238 4 a a DET dti-1357 238 5 role role NOUN dti-1357 238 6 as as ADP dti-1357 238 7 phosphoglycerate phosphoglycerate NOUN dti-1357 238 8 mutase mutase NOUN dti-1357 238 9 2,3 2,3 NUM dti-1357 238 10 - - PUNCT dti-1357 238 11 bisphosphoglycerate bisphosphoglycerate ADJ dti-1357 238 12 - - PUNCT dti-1357 238 13 independent independent ADJ dti-1357 238 14 enzyme enzyme NOUN dti-1357 238 15 in in ADP dti-1357 238 16 glucose glucose NOUN dti-1357 238 17 metabolism metabolism NOUN dti-1357 238 18 . . PUNCT dti-1357 239 1 mho_4370 mho_4370 PROPN dti-1357 239 2 and and CCONJ dti-1357 239 3 mho_2040 mho_2040 PROPN dti-1357 239 4 were be AUX dti-1357 239 5 recognized recognize VERB dti-1357 239 6 as as ADP dti-1357 239 7 glycerol-3 glycerol-3 NOUN dti-1357 239 8 - - PUNCT dti-1357 239 9 phosphate phosphate NOUN dti-1357 239 10 acyltransferase acyltransferase NOUN dti-1357 239 11 ( ( PUNCT dti-1357 239 12 plsy plsy PROPN dti-1357 239 13 ) ) PUNCT dti-1357 239 14 and and CCONJ dti-1357 239 15 dna dna PROPN dti-1357 239 16 polymerase polymerase NOUN dti-1357 239 17 iii iii X dti-1357 239 18 ( ( PUNCT dti-1357 239 19 delta delta NOUN dti-1357 239 20 subunit subunit NOUN dti-1357 239 21 ) ) PUNCT dti-1357 239 22 type type NOUN dti-1357 239 23 proteins protein NOUN dti-1357 239 24 , , PUNCT dti-1357 239 25 respectively respectively ADV dti-1357 239 26 . . PUNCT dti-1357 240 1 mho_3690 mho_3690 NUM dti-1357 240 2 protein protein NOUN dti-1357 240 3 was be AUX dti-1357 240 4 predicted predict VERB dti-1357 240 5 to to PART dti-1357 240 6 be be AUX dti-1357 240 7 beta beta NOUN dti-1357 240 8 - - PUNCT dti-1357 240 9 lactamase lactamase NOUN dti-1357 240 10 - - PUNCT dti-1357 240 11 like like ADJ dti-1357 240 12 protein protein NOUN dti-1357 240 13 having have VERB dti-1357 240 14 rnaand rnaand NOUN dti-1357 240 15 metal metal NOUN dti-1357 240 16 ion ion NOUN dti-1357 240 17 - - PUNCT dti-1357 240 18 binding bind VERB dti-1357 240 19 potential potential NOUN dti-1357 240 20 . . PUNCT dti-1357 241 1 the the DET dti-1357 241 2 mho_0010 mho_0010 PROPN dti-1357 241 3 was be AUX dti-1357 241 4 recognized recognize VERB dti-1357 241 5 as as ADP dti-1357 241 6 membrane membrane NOUN dti-1357 241 7 insertase insertase NOUN dti-1357 241 8 yidc yidc PROPN dti-1357 241 9 / / SYM dti-1357 241 10 oxa1 oxa1 PROPN dti-1357 241 11 ( ( PUNCT dti-1357 241 12 c c NOUN dti-1357 241 13 - - PUNCT dti-1357 241 14 terminal terminal NOUN dti-1357 241 15 ) ) PUNCT dti-1357 241 16 having have VERB dti-1357 241 17 a a DET dti-1357 241 18 pivotal pivotal ADJ dti-1357 241 19 role role NOUN dti-1357 241 20 in in ADP dti-1357 241 21 protein protein NOUN dti-1357 241 22 insertion insertion NOUN dti-1357 241 23 into into ADP dti-1357 241 24 the the DET dti-1357 241 25 membrane membrane NOUN dti-1357 241 26 . . PUNCT dti-1357 242 1 interpro interpro PROPN dti-1357 242 2 could could AUX dti-1357 242 3 not not PART dti-1357 242 4 predict predict VERB dti-1357 242 5 any any DET dti-1357 242 6 function function NOUN dti-1357 242 7 for for ADP dti-1357 242 8 mho_4440 mho_4440 PROPN dti-1357 242 9 and and CCONJ dti-1357 242 10 mho_4480 mho_4480 PROPN dti-1357 242 11 as as SCONJ dti-1357 242 12 no no DET dti-1357 242 13 homolog homolog NOUN dti-1357 242 14 was be AUX dti-1357 242 15 found find VERB dti-1357 242 16 in in ADP dti-1357 242 17 the the DET dti-1357 242 18 database database NOUN dti-1357 242 19 . . PUNCT dti-1357 243 1 comparison comparison NOUN dti-1357 243 2 of of ADP dti-1357 243 3 proteomes proteome NOUN dti-1357 243 4 of of ADP dti-1357 243 5 240 240 NUM dti-1357 243 6 pathogens pathogen NOUN dti-1357 243 7 identified identify VERB dti-1357 243 8 12 12 NUM dti-1357 243 9 broad broad ADJ dti-1357 243 10 spectrum spectrum NOUN dti-1357 243 11 targets target NOUN dti-1357 243 12 . . PUNCT dti-1357 244 1 blastp blastp PROPN dti-1357 244 2 homology homology PROPN dti-1357 244 3 search search NOUN dti-1357 244 4 for for ADP dti-1357 244 5 proteins protein NOUN dti-1357 244 6 in in ADP dti-1357 244 7 the the DET dti-1357 244 8 ∑ ∑ NOUN dti-1357 244 9 list list NOUN dti-1357 244 10 against against ADP dti-1357 244 11 the the DET dti-1357 244 12 whole whole ADJ dti-1357 244 13 proteome proteome NOUN dti-1357 244 14 of of ADP dti-1357 244 15 each each PRON dti-1357 244 16 of of ADP dti-1357 244 17 the the DET dti-1357 244 18 240 240 NUM dti-1357 244 19 bacterial bacterial ADJ dti-1357 244 20 pathogens pathogen NOUN dti-1357 244 21 identified identify VERB dti-1357 244 22 ideal ideal ADJ dti-1357 244 23 broad broad ADJ dti-1357 244 24 spectrum spectrum NOUN dti-1357 244 25 targets target NOUN dti-1357 244 26 . . PUNCT dti-1357 245 1 this this DET dti-1357 245 2 comparative comparative ADJ dti-1357 245 3 sequence sequence NOUN dti-1357 245 4 analysis analysis NOUN dti-1357 245 5 revealed reveal VERB dti-1357 245 6 12 12 NUM dti-1357 245 7 proteins protein NOUN dti-1357 245 8 having have VERB dti-1357 245 9 homologs homolog NOUN dti-1357 245 10 in in ADP dti-1357 245 11 more more ADJ dti-1357 245 12 than than ADP dti-1357 245 13 100 100 NUM dti-1357 245 14 pathogens pathogen NOUN dti-1357 245 15 , , PUNCT dti-1357 245 16 whereas whereas SCONJ dti-1357 245 17 homologs homolog NOUN dti-1357 245 18 were be AUX dti-1357 245 19 found find VERB dti-1357 245 20 in in ADP dti-1357 245 21 more more ADJ dti-1357 245 22 than than ADP dti-1357 245 23 50 50 NUM dti-1357 245 24 pathogens pathogen NOUN dti-1357 245 25 for for ADP dti-1357 245 26 33 33 NUM dti-1357 245 27 proteins protein NOUN dti-1357 245 28 present present ADJ dti-1357 245 29 in in ADP dti-1357 245 30 the the DET dti-1357 245 31 ∑ ∑ NOUN dti-1357 245 32 list list NOUN dti-1357 245 33 . . PUNCT dti-1357 246 1 ∑ ∑ ADV dti-1357 246 2 listed list VERB dti-1357 246 3 proteins protein NOUN dti-1357 246 4 exhibit exhibit VERB dti-1357 246 5 maximum maximum ADJ dti-1357 246 6 homology homology NOUN dti-1357 246 7 to to ADP dti-1357 246 8 the the DET dti-1357 246 9 proteome proteome PROPN dti-1357 246 10 of of ADP dti-1357 246 11 mycoplasma mycoplasma NOUN dti-1357 246 12 pathogens pathogen NOUN dti-1357 246 13 like like ADP dti-1357 246 14 m. m. NOUN dti-1357 246 15 capricolum capricolum PROPN dti-1357 246 16 , , PUNCT dti-1357 246 17 m. m. NOUN dti-1357 246 18 gallisepticum gallisepticum NOUN dti-1357 246 19 , , PUNCT dti-1357 246 20 m. m. NOUN dti-1357 246 21 genitallium genitallium NOUN dti-1357 246 22 , , PUNCT dti-1357 246 23 m. m. NOUN dti-1357 246 24 penetrans penetran NOUN dti-1357 246 25 , , PUNCT dti-1357 246 26 and and CCONJ dti-1357 246 27 m. m. NOUN dti-1357 246 28 pneumoniae pneumoniae NOUN dti-1357 246 29 . . PUNCT dti-1357 247 1 proteins protein NOUN dti-1357 247 2 having have VERB dti-1357 247 3 homologs homolog NOUN dti-1357 247 4 in in ADP dti-1357 247 5 more more ADJ dti-1357 247 6 than than ADP dti-1357 247 7 100 100 NUM dti-1357 247 8 pathogens pathogen NOUN dti-1357 247 9 were be AUX dti-1357 247 10 considered consider VERB dti-1357 247 11 as as ADP dti-1357 247 12 broad broad ADJ dti-1357 247 13 spectrum spectrum NOUN dti-1357 247 14 target target NOUN dti-1357 247 15 candidates candidate NOUN dti-1357 247 16 ( ( PUNCT dti-1357 247 17 table table NOUN dti-1357 247 18 2 2 NUM dti-1357 247 19 ) ) PUNCT dti-1357 247 20 . . PUNCT dti-1357 248 1 interactome interactome NOUN dti-1357 248 2 analysis analysis NOUN dti-1357 248 3 identified identify VERB dti-1357 248 4 23 23 NUM dti-1357 248 5 targets target NOUN dti-1357 248 6 having have VERB dti-1357 248 7 maximum maximum ADJ dti-1357 248 8 interactors interactor NOUN dti-1357 248 9 . . PUNCT dti-1357 249 1 protein protein NOUN dti-1357 249 2 – – PUNCT dti-1357 249 3 protein protein NOUN dti-1357 249 4 interactions interaction NOUN dti-1357 249 5 are be AUX dti-1357 249 6 important important ADJ dti-1357 249 7 determinants determinant NOUN dti-1357 249 8 of of ADP dti-1357 249 9 protein protein NOUN dti-1357 249 10 function function NOUN dti-1357 249 11 . . PUNCT dti-1357 250 1 to to PART dti-1357 250 2 evaluate evaluate VERB dti-1357 250 3 the the DET dti-1357 250 4 functional functional ADJ dti-1357 250 5 importance importance NOUN dti-1357 250 6 of of ADP dti-1357 250 7 ∑ ∑ PUNCT dti-1357 250 8 listed list VERB dti-1357 250 9 targets target NOUN dti-1357 250 10 in in ADP dti-1357 250 11 the the DET dti-1357 250 12 metabolic metabolic NOUN dti-1357 250 13 network network NOUN dti-1357 250 14 , , PUNCT dti-1357 250 15 analysis analysis NOUN dti-1357 250 16 on on ADP dti-1357 250 17 protein protein NOUN dti-1357 250 18 interaction interaction NOUN dti-1357 250 19 network network NOUN dti-1357 250 20 was be AUX dti-1357 250 21 performed perform VERB dti-1357 250 22 using use VERB dti-1357 250 23 the the DET dti-1357 250 24 string string NOUN dti-1357 250 25 database database NOUN dti-1357 250 26 . . PUNCT dti-1357 251 1 target target NOUN dti-1357 251 2 protein protein NOUN dti-1357 251 3 interacting interact VERB dti-1357 251 4 with with ADP dti-1357 251 5 http://www.la-press.com http://www.la-press.com X dti-1357 251 6 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1357 251 7 parvege parvege PROPN dti-1357 251 8 et et PROPN dti-1357 251 9 al al PROPN dti-1357 251 10 58 58 NUM dti-1357 251 11 drug drug NOUN dti-1357 251 12 target target NOUN dti-1357 251 13 insights insight VERB dti-1357 251 14 2014:8 2014:8 NUM dti-1357 251 15 table table NOUN dti-1357 251 16 3 3 NUM dti-1357 251 17 . . PUNCT dti-1357 252 1 non non ADJ dti-1357 252 2 - - ADJ dti-1357 252 3 host host ADJ dti-1357 252 4 essential essential ADJ dti-1357 252 5 proteins protein NOUN dti-1357 252 6 similar similar ADJ dti-1357 252 7 to to ADP dti-1357 252 8 fda fda PROPN dti-1357 252 9 - - PUNCT dti-1357 252 10 approved approve VERB dti-1357 252 11 / / SYM dti-1357 252 12 experimental experimental ADJ dti-1357 252 13 drug drug NOUN dti-1357 252 14 targets target NOUN dti-1357 252 15 and and CCONJ dti-1357 252 16 the the DET dti-1357 252 17 list list NOUN dti-1357 252 18 of of ADP dti-1357 252 19 fda fda PROPN dti-1357 252 20 - - PUNCT dti-1357 252 21 approved approve VERB dti-1357 252 22 drugs drug NOUN dti-1357 252 23 for for ADP dti-1357 252 24 the the DET dti-1357 252 25 targets target NOUN dti-1357 252 26 . . PUNCT dti-1357 253 1 no no DET dti-1357 253 2 kegg kegg NOUN dti-1357 253 3 i i PROPN dti-1357 253 4 d d PROPN dti-1357 253 5 associated associate VERB dti-1357 253 6 pathways pathway NOUN dti-1357 253 7 drugbank drugbank NOUN dti-1357 254 1 i i PROPN dti-1357 254 2 d d PROPN dti-1357 254 3 drug drug NOUN dti-1357 254 4 name name NOUN dti-1357 254 5 drug drug NOUN dti-1357 254 6 group group NOUN dti-1357 254 7 1 1 NUM dti-1357 254 8 mho_0670 mho_0670 PROPN dti-1357 254 9 glycolysis glycolysis NOUN dti-1357 254 10 / / SYM dti-1357 254 11 gluconeogenesis gluconeogenesis NOUN dti-1357 254 12 , , PUNCT dti-1357 254 13 pentose pentose NOUN dti-1357 254 14 phosphate phosphate ADJ dti-1357 254 15 pathway pathway NOUN dti-1357 254 16 , , PUNCT dti-1357 254 17 fructose fructose NOUN dti-1357 254 18 and and CCONJ dti-1357 254 19 mannose mannose NOUN dti-1357 254 20 metabolism metabolism NOUN dti-1357 254 21 db03026 db03026 PROPN dti-1357 254 22 phosphoglycolohydroxamic phosphoglycolohydroxamic ADJ dti-1357 254 23 acid acid PROPN dti-1357 254 24 experimental experimental ADJ dti-1357 254 25 2 2 NUM dti-1357 254 26 mho_0100 mho_0100 PROPN dti-1357 254 27 cysteine cysteine NOUN dti-1357 254 28 and and CCONJ dti-1357 254 29 methionine methionine NOUN dti-1357 254 30 metabolism metabolism NOUN dti-1357 254 31 , , PUNCT dti-1357 254 32 biosynthesis biosynthesis NOUN dti-1357 254 33 of of ADP dti-1357 254 34 amino amino ADJ dti-1357 254 35 acids acid NOUN dti-1357 254 36 db07463 db07463 PROPN dti-1357 254 37 , , PUNCT dti-1357 254 38 db00173 db00173 PROPN dti-1357 254 39 adenine adenine NOUN dti-1357 254 40 approved approve VERB dti-1357 254 41 3 3 NUM dti-1357 254 42 mho_0980 mho_0980 NUM dti-1357 254 43 pyrimidine pyrimidine NOUN dti-1357 254 44 metabolism metabolism NOUN dti-1357 254 45 db03280 db03280 PROPN dti-1357 254 46 p1-(5′-adenosyl)p5-(5′-thymidyl p1-(5′-adenosyl)p5-(5′-thymidyl NOUN dti-1357 254 47 ) ) PUNCT dti-1357 254 48 pentaphosphate pentaphosphate NOUN dti-1357 254 49 experimental experimental ADJ dti-1357 254 50 4 4 NUM dti-1357 254 51 mho_1260 mho_1260 NUM dti-1357 254 52 nicotinate nicotinate ADJ dti-1357 254 53 and and CCONJ dti-1357 254 54 nicotinamide nicotinamide NOUN dti-1357 254 55 metabolism metabolism NOUN dti-1357 254 56 db04099 db04099 NOUN dti-1357 254 57 , , PUNCT dti-1357 254 58 db04272 db04272 PROPN dti-1357 254 59 deamido deamido PROPN dti-1357 254 60 - - PUNCT dti-1357 254 61 nad+ nad+ NOUN dti-1357 254 62 , , PUNCT dti-1357 254 63 citric citric ADJ dti-1357 254 64 acid acid NOUN dti-1357 254 65 experimental experimental ADJ dti-1357 254 66 , , PUNCT dti-1357 254 67 nutraceutical nutraceutical ADJ dti-1357 254 68 5 5 NUM dti-1357 254 69 mho_1670 mho_1670 PROPN dti-1357 254 70 pyrimidine pyrimidine NOUN dti-1357 254 71 metabolism metabolism NOUN dti-1357 254 72 db02456 db02456 NOUN dti-1357 254 73 , , PUNCT dti-1357 254 74 db02883 db02883 PROPN dti-1357 254 75 , , PUNCT dti-1357 254 76 db03403 db03403 NOUN dti-1357 254 77 db04555 db04555 PROPN dti-1357 254 78 cytosine cytosine VERB dti-1357 254 79 arabinose-5′-phosphate arabinose-5′-phosphate NOUN dti-1357 254 80 , , PUNCT dti-1357 254 81 2′,3′-dideoxycytidine-5′-monophosphate 2′,3′-dideoxycytidine-5′-monophosphate NUM dti-1357 254 82 , , PUNCT dti-1357 254 83 cytidine-5′-monophosphate cytidine-5′-monophosphate ADJ dti-1357 254 84 , , PUNCT dti-1357 254 85 cytidine-5′-diphosphate cytidine-5′-diphosphate ADJ dti-1357 254 86 experimental experimental ADJ dti-1357 254 87 6 6 NUM dti-1357 254 88 mho_2730 mho_2730 NUM dti-1357 254 89 purine purine NOUN dti-1357 254 90 metabolism metabolism NOUN dti-1357 254 91 , , PUNCT dti-1357 254 92 pyrimidine pyrimidine NOUN dti-1357 254 93 metabolism metabolism NOUN dti-1357 254 94 , , PUNCT dti-1357 254 95 rna rna NOUN dti-1357 254 96 polymerase polymerase NOUN dti-1357 254 97 db00615 db00615 PROPN dti-1357 254 98 , , PUNCT dti-1357 254 99 db08226 db08226 PROPN dti-1357 254 100 , , PUNCT dti-1357 254 101 db08266 db08266 NOUN dti-1357 254 102 rifabutin rifabutin NOUN dti-1357 254 103 , , PUNCT dti-1357 254 104 myxopyronin myxopyronin PROPN dti-1357 254 105 b b PROPN dti-1357 254 106 , , PUNCT dti-1357 254 107 methyl methyl NOUN dti-1357 254 108 carbamate carbamate PROPN dti-1357 254 109 approved approve VERB dti-1357 254 110 , , PUNCT dti-1357 254 111 experimental experimental ADJ dti-1357 254 112 7 7 NUM dti-1357 254 113 mho_0210 mho_0210 PROPN dti-1357 254 114 oxidative oxidative ADJ dti-1357 254 115 phosphorylation phosphorylation NOUN dti-1357 254 116 db04464 db04464 ADV dti-1357 254 117 , , PUNCT dti-1357 254 118 db03143 db03143 PROPN dti-1357 254 119 n n CCONJ dti-1357 254 120 - - PUNCT dti-1357 254 121 formylmethionine formylmethionine NOUN dti-1357 254 122 , , PUNCT dti-1357 254 123 nonan-1 nonan-1 NUM dti-1357 254 124 - - ADJ dti-1357 254 125 ol ol ADJ dti-1357 254 126 experimental experimental ADJ dti-1357 254 127 8 8 NUM dti-1357 254 128 mho_3350 mho_3350 PROPN dti-1357 254 129 purine purine NOUN dti-1357 254 130 metabolism metabolism NOUN dti-1357 254 131 , , PUNCT dti-1357 254 132 pyrimidine pyrimidine NOUN dti-1357 254 133 metabolism metabolism NOUN dti-1357 254 134 , , PUNCT dti-1357 254 135 nicotinate nicotinate ADJ dti-1357 254 136 and and CCONJ dti-1357 254 137 nicotinamide nicotinamide NOUN dti-1357 254 138 metabolism metabolism NOUN dti-1357 254 139 , , PUNCT dti-1357 254 140 biosynthesis biosynthesis NOUN dti-1357 254 141 of of ADP dti-1357 254 142 secondary secondary ADJ dti-1357 254 143 metabolites metabolite NOUN dti-1357 254 144 db02857 db02857 PROPN dti-1357 254 145 , , PUNCT dti-1357 254 146 db04627 db04627 PROPN dti-1357 254 147 guanosine guanosine PROPN dti-1357 254 148 , , PUNCT dti-1357 254 149 cyclouridine cyclouridine NOUN dti-1357 254 150 experimental experimental ADJ dti-1357 254 151 9 9 NUM dti-1357 254 152 mho_3810 mho_3810 NOUN dti-1357 254 153 glycolysis glycolysis NOUN dti-1357 254 154 / / SYM dti-1357 254 155 gluconeogenesis gluconeogenesis NOUN dti-1357 254 156 , , PUNCT dti-1357 254 157 glycine glycine NOUN dti-1357 254 158 , , PUNCT dti-1357 254 159 serine serine NOUN dti-1357 254 160 and and CCONJ dti-1357 254 161 threonine threonine ADJ dti-1357 254 162 metabolism metabolism NOUN dti-1357 254 163 , , PUNCT dti-1357 254 164 methane methane NOUN dti-1357 254 165 metabolism metabolism NOUN dti-1357 254 166 db01709 db01709 NOUN dti-1357 254 167 , , PUNCT dti-1357 254 168 db04510 db04510 ADJ dti-1357 254 169 2 2 NUM dti-1357 254 170 - - PUNCT dti-1357 254 171 phosphoglyceric phosphoglyceric ADJ dti-1357 254 172 acid acid NOUN dti-1357 254 173 , , PUNCT dti-1357 254 174 3 3 NUM dti-1357 254 175 - - PUNCT dti-1357 254 176 phosphoglyceric phosphoglyceric ADJ dti-1357 254 177 acid acid NOUN dti-1357 254 178 experimental experimental ADJ dti-1357 254 179 10 10 NUM dti-1357 254 180 mho_3840 mho_3840 NOUN dti-1357 254 181 pyruvate pyruvate NOUN dti-1357 254 182 metabolism metabolism NOUN dti-1357 254 183 , , PUNCT dti-1357 254 184 propanoate propanoate ADJ dti-1357 254 185 metabolism metabolism NOUN dti-1357 254 186 , , PUNCT dti-1357 254 187 methane methane NOUN dti-1357 254 188 metabolism metabolism NOUN dti-1357 254 189 db01942 db01942 VERB dti-1357 254 190 formic formic ADJ dti-1357 254 191 acid acid NOUN dti-1357 254 192 experimental experimental ADJ dti-1357 254 193 11 11 NUM dti-1357 254 194 mho_3880 mho_3880 NUM dti-1357 254 195 pentose pentose NOUN dti-1357 254 196 phosphate phosphate ADJ dti-1357 254 197 pathway pathway NOUN dti-1357 254 198 , , PUNCT dti-1357 254 199 fructose fructose NOUN dti-1357 254 200 and and CCONJ dti-1357 254 201 mannose mannose NOUN dti-1357 254 202 metabolism metabolism NOUN dti-1357 254 203 , , PUNCT dti-1357 254 204 biosynthesis biosynthesis NOUN dti-1357 254 205 of of ADP dti-1357 254 206 secondary secondary ADJ dti-1357 254 207 metabolites metabolite NOUN dti-1357 254 208 db03661 db03661 ADJ dti-1357 254 209 , , PUNCT dti-1357 254 210 db03108 db03108 NOUN dti-1357 254 211 cysteinesulfonic cysteinesulfonic ADJ dti-1357 254 212 acid acid NOUN dti-1357 254 213 , , PUNCT dti-1357 254 214 4 4 NUM dti-1357 254 215 - - PUNCT dti-1357 254 216 phospho phospho ADJ dti-1357 254 217 - - PUNCT dti-1357 254 218 d d NOUN dti-1357 254 219 - - NOUN dti-1357 254 220 erythronate erythronate NOUN dti-1357 254 221 experimental experimental ADJ dti-1357 254 222 12 12 NUM dti-1357 254 223 mho_4130 mho_4130 PROPN dti-1357 254 224 purine purine NOUN dti-1357 254 225 metabolism metabolism NOUN dti-1357 254 226 , , PUNCT dti-1357 254 227 pyrimidine pyrimidine NOUN dti-1357 254 228 metabolism metabolism NOUN dti-1357 254 229 , , PUNCT dti-1357 254 230 nucleotide nucleotide ADJ dti-1357 254 231 excision excision NOUN dti-1357 254 232 repair repair NOUN dti-1357 254 233 , , PUNCT dti-1357 254 234 homologous homologous ADJ dti-1357 254 235 recombination recombination NOUN dti-1357 254 236 db00548 db00548 NOUN dti-1357 254 237 , , PUNCT dti-1357 254 238 db03152 db03152 PROPN dti-1357 254 239 azelaic azelaic PROPN dti-1357 254 240 acid acid PROPN dti-1357 254 241 , , PUNCT dti-1357 254 242 b-2 b-2 NOUN dti-1357 254 243 - - PUNCT dti-1357 254 244 octylglucoside octylglucoside NOUN dti-1357 254 245 approved approve VERB dti-1357 254 246 , , PUNCT dti-1357 254 247 experimental experimental ADJ dti-1357 254 248 13 13 NUM dti-1357 254 249 mho_1180 mho_1180 NUM dti-1357 254 250 aminoacyl aminoacyl PROPN dti-1357 254 251 - - PUNCT dti-1357 254 252 trna trna NOUN dti-1357 254 253 biosynthesis biosynthesis NOUN dti-1357 254 254 db07817 db07817 NOUN dti-1357 254 255 1-{3-[(4 1-{3-[(4 NUM dti-1357 254 256 - - PUNCT dti-1357 254 257 pyridin-2 pyridin-2 NUM dti-1357 254 258 - - PUNCT dti-1357 254 259 ylpiperazin-1 ylpiperazin-1 NOUN dti-1357 254 260 - - PUNCT dti-1357 254 261 14yl 14yl NOUN dti-1357 254 262 ) ) PUNCT dti-1357 254 263 sulfonyl]phenyl}-3-(1,3 sulfonyl]phenyl}-3-(1,3 VERB dti-1357 254 264 - - PUNCT dti-1357 254 265 thiazol-2 thiazol-2 NOUN dti-1357 254 266 - - PUNCT dti-1357 254 267 yl)urea yl)urea NOUN dti-1357 254 268 experimental experimental ADJ dti-1357 254 269 14 14 NUM dti-1357 254 270 mho_0050 mho_0050 NUM dti-1357 254 271 purine purine NOUN dti-1357 254 272 metabolism metabolism NOUN dti-1357 254 273 , , PUNCT dti-1357 254 274 pyrimidine pyrimidine NOUN dti-1357 254 275 metabolism metabolism NOUN dti-1357 254 276 , , PUNCT dti-1357 254 277 dna dna NOUN dti-1357 254 278 replication replication NOUN dti-1357 254 279 , , PUNCT dti-1357 254 280 mismatch mismatch ADJ dti-1357 254 281 repair repair NOUN dti-1357 254 282 , , PUNCT dti-1357 254 283 homologous homologous ADJ dti-1357 254 284 recombination recombination NOUN dti-1357 254 285 db06998 db06998 PROPN dti-1357 255 1 [ [ X dti-1357 255 2 ( ( PUNCT dti-1357 255 3 5r)-5-(2,3 5r)-5-(2,3 ADJ dti-1357 255 4 - - PUNCT dti-1357 255 5 dibromo-5 dibromo-5 VERB dti-1357 255 6 - - PUNCT dti-1357 255 7 ethoxy-4hydroxybenzyl)-4 ethoxy-4hydroxybenzyl)-4 VERB dti-1357 255 8 - - PUNCT dti-1357 255 9 oxo-2 oxo-2 NOUN dti-1357 255 10 - - PUNCT dti-1357 255 11 thioxo-1,3thiazolidin-3 thioxo-1,3thiazolidin-3 ADV dti-1357 255 12 - - PUNCT dti-1357 255 13 yl]acetic yl]acetic ADJ dti-1357 255 14 acid acid NOUN dti-1357 255 15 experimental experimental ADJ dti-1357 255 16 15 15 NUM dti-1357 255 17 mho_2700 mho_2700 NUM dti-1357 255 18 ribosome ribosome ADJ dti-1357 255 19 db00778 db00778 NOUN dti-1357 255 20 , , PUNCT dti-1357 255 21 db01190 db01190 NOUN dti-1357 255 22 , , PUNCT dti-1357 255 23 db01211 db01211 PROPN dti-1357 255 24 , , PUNCT dti-1357 255 25 db01369 db01369 PROPN dti-1357 255 26 , , PUNCT dti-1357 255 27 db01627 db01627 NOUN dti-1357 255 28 roxithromycin roxithromycin NOUN dti-1357 255 29 , , PUNCT dti-1357 255 30 clindamycin clindamycin NOUN dti-1357 255 31 , , PUNCT dti-1357 255 32 clarithromycin clarithromycin PROPN dti-1357 255 33 , , PUNCT dti-1357 255 34 quinupristin quinupristin PROPN dti-1357 255 35 , , PUNCT dti-1357 255 36 lincomycin lincomycin PROPN dti-1357 255 37 approved approve VERB dti-1357 255 38 16 16 NUM dti-1357 255 39 mho_2710 mho_2710 NUM dti-1357 255 40 ribosome ribosome ADJ dti-1357 255 41 db01361 db01361 NOUN dti-1357 255 42 troleandomycin troleandomycin PROPN dti-1357 255 43 approved approve VERB dti-1357 255 44 more more ADJ dti-1357 255 45 proteins protein NOUN dti-1357 255 46 is be AUX dti-1357 255 47 considered consider VERB dti-1357 255 48 as as ADP dti-1357 255 49 metabolically metabolically ADV dti-1357 255 50 important important ADJ dti-1357 255 51 active active ADJ dti-1357 255 52 protein protein NOUN dti-1357 255 53 , , PUNCT dti-1357 255 54 which which PRON dti-1357 255 55 can can AUX dti-1357 255 56 act act VERB dti-1357 255 57 as as ADP dti-1357 255 58 an an DET dti-1357 255 59 appropriate appropriate ADJ dti-1357 255 60 drug drug NOUN dti-1357 255 61 target.41,42 target.41,42 NOUN dti-1357 255 62 out out ADP dti-1357 255 63 of of ADP dti-1357 255 64 57 57 NUM dti-1357 255 65 input input NOUN dti-1357 255 66 proteins protein NOUN dti-1357 255 67 , , PUNCT dti-1357 255 68 12 12 NUM dti-1357 255 69 were be AUX dti-1357 255 70 found find VERB dti-1357 255 71 to to PART dti-1357 255 72 have have VERB dti-1357 255 73 less less ADJ dti-1357 255 74 than than ADP dti-1357 255 75 five five NUM dti-1357 255 76 interactors interactor NOUN dti-1357 255 77 and and CCONJ dti-1357 255 78 23 23 NUM dti-1357 255 79 to to PART dti-1357 255 80 have have VERB dti-1357 255 81 more more ADJ dti-1357 255 82 than than ADP dti-1357 255 83 10 10 NUM dti-1357 255 84 interactors interactor NOUN dti-1357 255 85 ( ( PUNCT dti-1357 255 86 table table NOUN dti-1357 255 87 2 2 NUM dti-1357 255 88 ) ) PUNCT dti-1357 255 89 . . PUNCT dti-1357 256 1 drugbank drugbank NOUN dti-1357 256 2 database database PROPN dti-1357 256 3 search search NOUN dti-1357 256 4 identified identify VERB dti-1357 256 5 16 16 NUM dti-1357 256 6 druggable druggable ADJ dti-1357 256 7 targets target NOUN dti-1357 256 8 . . PUNCT dti-1357 257 1 the the DET dti-1357 257 2 probability probability NOUN dti-1357 257 3 of of ADP dti-1357 257 4 being be AUX dti-1357 257 5 druggable druggable ADJ dti-1357 257 6 of of ADP dti-1357 257 7 the the DET dti-1357 257 8 potential potential ADJ dti-1357 257 9 targets target NOUN dti-1357 257 10 can can AUX dti-1357 257 11 be be AUX dti-1357 257 12 evaluated evaluate VERB dti-1357 257 13 by by ADP dti-1357 257 14 sequence sequence NOUN dti-1357 257 15 similarity similarity NOUN dti-1357 257 16 search search NOUN dti-1357 257 17 against against ADP dti-1357 257 18 the the DET dti-1357 257 19 targets target NOUN dti-1357 257 20 from from ADP dti-1357 257 21 drugbank.38,39 drugbank.38,39 PROPN dti-1357 257 22 blastp blastp NOUN dti-1357 257 23 search search NOUN dti-1357 257 24 against against ADP dti-1357 257 25 drugbank drugbank NOUN dti-1357 257 26 targets target NOUN dti-1357 257 27 with with ADP dti-1357 257 28 fda fda PROPN dti-1357 257 29 - - PUNCT dti-1357 257 30 approved approve VERB dti-1357 257 31 drugs drug NOUN dti-1357 257 32 , , PUNCT dti-1357 257 33 nutraceuticals nutraceutical NOUN dti-1357 257 34 , , PUNCT dti-1357 257 35 and and CCONJ dti-1357 257 36 experimental experimental ADJ dti-1357 257 37 drugs drug NOUN dti-1357 257 38 revealed reveal VERB dti-1357 257 39 that that SCONJ dti-1357 257 40 16 16 NUM dti-1357 257 41 targets target NOUN dti-1357 257 42 in in ADP dti-1357 257 43 the the DET dti-1357 257 44 ∑ ∑ PUNCT dti-1357 257 45 list list NOUN dti-1357 257 46 are be AUX dti-1357 257 47 homologous homologous ADJ dti-1357 257 48 to to PART dti-1357 257 49 drugbank drugbank VERB dti-1357 257 50 targets target NOUN dti-1357 257 51 ( ( PUNCT dti-1357 257 52 table table NOUN dti-1357 257 53 3 3 NUM dti-1357 257 54 ) ) PUNCT dti-1357 257 55 . . PUNCT dti-1357 258 1 five five NUM dti-1357 258 2 targets target NOUN dti-1357 258 3 were be AUX dti-1357 258 4 found find VERB dti-1357 258 5 to to PART dti-1357 258 6 have have VERB dti-1357 258 7 homologies homology NOUN dti-1357 258 8 to to ADP dti-1357 258 9 fda fda PROPN dti-1357 258 10 - - PUNCT dti-1357 258 11 approved approve VERB dti-1357 258 12 drug drug NOUN dti-1357 258 13 targets target NOUN dti-1357 258 14 . . PUNCT dti-1357 259 1 among among ADP dti-1357 259 2 them they PRON dti-1357 259 3 , , PUNCT dti-1357 259 4 mho_2700 mho_2700 VERB dti-1357 259 5     SPACE dti-1357 259 6 is be AUX dti-1357 259 7 homologous homologous ADJ dti-1357 259 8 to to ADP dti-1357 259 9 a a DET dti-1357 259 10 known know VERB dti-1357 259 11 target target NOUN dti-1357 259 12 ( ( PUNCT dti-1357 259 13 50s 50 NOUN dti-1357 259 14 ribosomal ribosomal NOUN dti-1357 259 15 protein protein NOUN dti-1357 259 16 l10 l10 PROPN dti-1357 259 17 ) ) PUNCT dti-1357 259 18 and and CCONJ dti-1357 259 19 has have VERB dti-1357 259 20 five five NUM dti-1357 259 21 approved approve VERB dti-1357 259 22 drugs drug NOUN dti-1357 259 23 against against ADP dti-1357 259 24 it it PRON dti-1357 259 25 , , PUNCT dti-1357 259 26 named name VERB dti-1357 259 27 roxithromycin roxithromycin PROPN dti-1357 259 28 ( ( PUNCT dti-1357 259 29 db00778 db00778 PROPN dti-1357 259 30 ) ) PUNCT dti-1357 259 31 , , PUNCT dti-1357 259 32 clindamycin clindamycin NOUN dti-1357 259 33 ( ( PUNCT dti-1357 259 34 db01190 db01190 NOUN dti-1357 259 35 ) ) PUNCT dti-1357 259 36 , , PUNCT dti-1357 259 37 clarithromycin clarithromycin PROPN dti-1357 259 38 ( ( PUNCT dti-1357 259 39 db01190 db01190 PROPN dti-1357 259 40 ) ) PUNCT dti-1357 259 41 , , PUNCT dti-1357 259 42 quinupristin quinupristin NOUN dti-1357 259 43 ( ( PUNCT dti-1357 259 44 db01211 db01211 PROPN dti-1357 259 45 ) ) PUNCT dti-1357 259 46 , , PUNCT dti-1357 259 47 and and CCONJ dti-1357 259 48 lincomycin lincomycin PROPN dti-1357 259 49 ( ( PUNCT dti-1357 259 50 db01369 db01369 PROPN dti-1357 259 51 ) ) PUNCT dti-1357 259 52 , , PUNCT dti-1357 259 53 which which PRON dti-1357 259 54 are be AUX dti-1357 259 55 used use VERB dti-1357 259 56 to to PART dti-1357 259 57 treat treat VERB dti-1357 259 58 shigella shigella ADJ dti-1357 259 59 infection infection NOUN dti-1357 259 60 . . PUNCT dti-1357 260 1 other other ADJ dti-1357 260 2 four four NUM dti-1357 260 3 fda fda PROPN dti-1357 260 4 - - PUNCT dti-1357 260 5 approved approve VERB dti-1357 260 6 drug drug NOUN dti-1357 260 7 targets target NOUN dti-1357 260 8 have have VERB dti-1357 260 9 one one NUM dti-1357 260 10 approved approve VERB dti-1357 260 11 drug drug NOUN dti-1357 260 12 against against ADP dti-1357 260 13 each each PRON dti-1357 260 14 . . PUNCT dti-1357 261 1 proteins protein NOUN dti-1357 261 2 in in ADP dti-1357 261 3 the the DET dti-1357 261 4 ∑ ∑ PROPN dti-1357 261 5 list list NOUN dti-1357 261 6 that that PRON dti-1357 261 7 did do AUX dti-1357 261 8 not not PART dti-1357 261 9 hit hit VERB dti-1357 261 10 with with ADP dti-1357 261 11 drugbank drugbank NOUN dti-1357 261 12 database database NOUN dti-1357 261 13 are be AUX dti-1357 261 14 novel novel ADJ dti-1357 261 15 therapeutic therapeutic ADJ dti-1357 261 16 targets target NOUN dti-1357 261 17 for for ADP dti-1357 261 18 which which PRON dti-1357 261 19 new new ADJ dti-1357 261 20 drug drug NOUN dti-1357 261 21 and and CCONJ dti-1357 261 22 vaccines vaccine NOUN dti-1357 261 23 can can AUX dti-1357 261 24 be be AUX dti-1357 261 25 developed develop VERB dti-1357 261 26 . . PUNCT dti-1357 262 1 ranking rank VERB dti-1357 262 2 of of ADP dti-1357 262 3 the the DET dti-1357 262 4 drug drug NOUN dti-1357 262 5 targets target NOUN dti-1357 262 6 suggests suggest VERB dti-1357 262 7 that that SCONJ dti-1357 262 8 50s 50 NOUN dti-1357 262 9 ribosomal ribosomal NOUN dti-1357 262 10 protein protein NOUN dti-1357 262 11 l10 l10 NOUN dti-1357 262 12 has have VERB dti-1357 262 13 the the DET dti-1357 262 14 highest high ADJ dti-1357 262 15 potential potential NOUN dti-1357 262 16 to to PART dti-1357 262 17 be be AUX dti-1357 262 18 an an DET dti-1357 262 19 effective effective ADJ dti-1357 262 20 drug drug NOUN dti-1357 262 21 target target NOUN dti-1357 262 22 . . PUNCT dti-1357 263 1 it it PRON dti-1357 263 2 is be AUX dti-1357 263 3 useful useful ADJ dti-1357 263 4 to to PART dti-1357 263 5 rank rank VERB dti-1357 263 6 the the DET dti-1357 263 7 putative putative ADJ dti-1357 263 8 therapeutic therapeutic ADJ dti-1357 263 9 targets target NOUN dti-1357 263 10 based base VERB dti-1357 263 11 http://www.la-press.com http://www.la-press.com X dti-1357 263 12 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1357 263 13 identification identification NOUN dti-1357 263 14 of of ADP dti-1357 263 15 therapeutic therapeutic ADJ dti-1357 263 16 targets target NOUN dti-1357 263 17 in in ADP dti-1357 263 18 mycoplasma mycoplasma NOUN dti-1357 263 19 hominis hominis X dti-1357 263 20 59drug 59drug PROPN dti-1357 263 21 target target NOUN dti-1357 263 22 insights insight VERB dti-1357 263 23 2014:8 2014:8 NUM dti-1357 263 24 table table NOUN dti-1357 263 25 4 4 NUM dti-1357 263 26 . . PUNCT dti-1357 263 27 rankings ranking NOUN dti-1357 263 28 of of ADP dti-1357 263 29 the the DET dti-1357 263 30 druggable druggable ADJ dti-1357 263 31 targets target NOUN dti-1357 263 32 based base VERB dti-1357 263 33 on on ADP dti-1357 263 34 drug drug NOUN dti-1357 263 35 target target NOUN dti-1357 263 36 score score NOUN dti-1357 263 37 . . PUNCT dti-1357 264 1 kegg kegg NOUN dti-1357 264 2 i i PROPN dti-1357 264 3 d d PROPN dti-1357 264 4 gene gene NOUN dti-1357 264 5 product product NOUN dti-1357 264 6 definition definition NOUN dti-1357 264 7 homologs homolog NOUN dti-1357 264 8 in in ADP dti-1357 264 9 deg deg PROPN dti-1357 264 10 interactors interactors PROPN dti-1357 264 11 drugbank drugbank VERB dti-1357 264 12 hits hit VERB dti-1357 264 13 drug drug NOUN dti-1357 264 14 target target NOUN dti-1357 264 15 score score NOUN dti-1357 264 16 rank rank PROPN dti-1357 264 17 mho_2700 mho_2700 NUM dti-1357 264 18 50s 50 NOUN dti-1357 264 19 ribosomal ribosomal NOUN dti-1357 264 20 protein protein NOUN dti-1357 264 21 l10 l10 NOUN dti-1357 264 22 7 7 NUM dti-1357 264 23 43 43 NUM dti-1357 264 24 5 5 NUM dti-1357 264 25 15.05 15.05 NUM dti-1357 264 26 1 1 NUM dti-1357 264 27 mho_1180 mho_1180 PROPN dti-1357 264 28 phenylalanyl phenylalanyl PROPN dti-1357 264 29 - - PUNCT dti-1357 264 30 trna trna ADJ dti-1357 264 31 synthetase synthetase NOUN dti-1357 264 32 subunit subunit NOUN dti-1357 264 33 beta beta NOUN dti-1357 264 34 26 26 NUM dti-1357 264 35 32 32 NUM dti-1357 264 36 1 1 NUM dti-1357 264 37 8.32 8.32 NUM dti-1357 264 38 2 2 NUM dti-1357 264 39 mho_1670 mho_1670 NOUN dti-1357 264 40 cytidylate cytidylate ADJ dti-1357 264 41 kinase kinase NOUN dti-1357 264 42 24 24 NUM dti-1357 264 43 8 8 NUM dti-1357 264 44 4 4 NUM dti-1357 264 45 7.68 7.68 NUM dti-1357 264 46 3 3 NUM dti-1357 264 47 mho_2710 mho_2710 PROPN dti-1357 264 48 50s 50 NOUN dti-1357 264 49 ribosomal ribosomal NOUN dti-1357 264 50 protein protein NOUN dti-1357 264 51 l32 l32 NOUN dti-1357 264 52 15 15 NUM dti-1357 264 53 34 34 NUM dti-1357 264 54 1 1 NUM dti-1357 264 55 5.1 5.1 NUM dti-1357 264 56 4 4 NUM dti-1357 264 57 mho_1260 mho_1260 NUM dti-1357 264 58 putative putative ADJ dti-1357 264 59 nicotinate nicotinate ADJ dti-1357 264 60 - - PUNCT dti-1357 264 61 nucleotide nucleotide NOUN dti-1357 264 62 adenylyl adenylyl NOUN dti-1357 264 63 transferase transferase NOUN dti-1357 264 64 19 19 NUM dti-1357 264 65 13 13 NUM dti-1357 264 66 2 2 NUM dti-1357 264 67 4.94 4.94 NUM dti-1357 264 68 5 5 NUM dti-1357 264 69 mho_0050 mho_0050 NUM dti-1357 264 70 dna dna PROPN dti-1357 264 71 polymerase polymerase NOUN dti-1357 264 72 iii iii X dti-1357 264 73 subunit subunit NOUN dti-1357 264 74 beta beta NOUN dti-1357 264 75 19 19 NUM dti-1357 264 76 24 24 NUM dti-1357 264 77 1 1 NUM dti-1357 264 78 4.56 4.56 NUM dti-1357 264 79 6 6 NUM dti-1357 265 1 mho_4130 mho_4130 PROPN dti-1357 265 2 dna dna PROPN dti-1357 265 3 polymerase polymerase NOUN dti-1357 265 4 i i PRON dti-1357 265 5 14 14 NUM dti-1357 265 6 13 13 NUM dti-1357 265 7 2 2 NUM dti-1357 265 8 3.64 3.64 NUM dti-1357 265 9 7 7 NUM dti-1357 265 10 mho_0980 mho_0980 NUM dti-1357 265 11 thymidylate thymidylate NOUN dti-1357 265 12 kinase kinase NOUN dti-1357 265 13 21 21 NUM dti-1357 265 14 10 10 NUM dti-1357 265 15 1 1 NUM dti-1357 265 16 2.1 2.1 NUM dti-1357 265 17 8 8 NUM dti-1357 265 18 mho_2730 mho_2730 NUM dti-1357 265 19 dna dna PROPN dti-1357 265 20 - - PUNCT dti-1357 265 21 directed direct VERB dti-1357 265 22 rna rna NOUN dti-1357 265 23 polymerase polymerase NOUN dti-1357 265 24 subunit subunit NOUN dti-1357 265 25 alpha alpha NOUN dti-1357 265 26 27 27 NUM dti-1357 265 27 2 2 NUM dti-1357 265 28 3 3 NUM dti-1357 265 29 1.62 1.62 NUM dti-1357 265 30 9 9 NUM dti-1357 265 31 mho_0670 mho_0670 NUM dti-1357 265 32 fructose fructose NOUN dti-1357 265 33 - - PUNCT dti-1357 265 34 bisphosphate bisphosphate NOUN dti-1357 265 35 aldolase aldolase NOUN dti-1357 265 36 12 12 NUM dti-1357 265 37 13 13 NUM dti-1357 265 38 1 1 NUM dti-1357 265 39 1.56 1.56 NUM dti-1357 265 40 10 10 NUM dti-1357 265 41 mho_3810 mho_3810 NOUN dti-1357 265 42 putative putative ADJ dti-1357 265 43 2 2 NUM dti-1357 265 44 , , PUNCT dti-1357 265 45 3 3 NUM dti-1357 265 46 - - PUNCT dti-1357 265 47 bisphosphoglycerate bisphosphoglycerate NOUN dti-1357 265 48 - - PUNCT dti-1357 265 49 independent independent ADJ dti-1357 265 50 phosphoglycerate phosphoglycerate NOUN dti-1357 265 51 mutase mutase NOUN dti-1357 265 52 8 8 NUM dti-1357 265 53 9 9 NUM dti-1357 265 54 2 2 NUM dti-1357 265 55 1.44 1.44 NUM dti-1357 265 56 11 11 NUM dti-1357 265 57 mho_3880 mho_3880 NUM dti-1357 265 58 ribose-5 ribose-5 NUM dti-1357 265 59 - - PUNCT dti-1357 265 60 phosphate phosphate NOUN dti-1357 265 61 isomerase isomerase NOUN dti-1357 265 62 5 5 NUM dti-1357 265 63 9 9 NUM dti-1357 265 64 2 2 NUM dti-1357 265 65 0.9 0.9 NUM dti-1357 265 66 12 12 NUM dti-1357 265 67 mho_0210 mho_0210 PROPN dti-1357 265 68 atp atp NOUN dti-1357 265 69 synthase synthase NOUN dti-1357 265 70 subunit subunit NOUN dti-1357 265 71 c c PROPN dti-1357 265 72 2 2 NUM dti-1357 265 73 13 13 NUM dti-1357 265 74 2 2 NUM dti-1357 265 75 0.52 0.52 NUM dti-1357 265 76 13 13 NUM dti-1357 265 77 mho_3840 mho_3840 NOUN dti-1357 265 78 acetate acetate NOUN dti-1357 265 79 kinase kinase PROPN dti-1357 265 80 6 6 NUM dti-1357 265 81 7 7 NUM dti-1357 265 82 1 1 NUM dti-1357 265 83 0.42 0.42 NUM dti-1357 265 84 14 14 NUM dti-1357 265 85 mho_3350 mho_3350 PROPN dti-1357 265 86 purine purine NOUN dti-1357 265 87 - - PUNCT dti-1357 265 88 nucleoside nucleoside NOUN dti-1357 265 89 phosphorylase phosphorylase NOUN dti-1357 265 90 2 2 NUM dti-1357 265 91 9 9 NUM dti-1357 265 92 2 2 NUM dti-1357 265 93 0.36 0.36 NUM dti-1357 265 94 15 15 NUM dti-1357 265 95 mho_0100 mho_0100 PROPN dti-1357 265 96 putative putative ADJ dti-1357 265 97 nucleoside nucleoside NOUN dti-1357 265 98 phosphorylase phosphorylase NOUN dti-1357 265 99 2 2 NUM dti-1357 266 1 4 4 NUM dti-1357 266 2 2 2 NUM dti-1357 266 3 0.16 0.16 NUM dti-1357 266 4 16 16 NUM dti-1357 266 5 note note NOUN dti-1357 266 6 : : PUNCT dti-1357 266 7 drug drug NOUN dti-1357 266 8 target target NOUN dti-1357 266 9 score score NOUN dti-1357 266 10 = = NOUN dti-1357 266 11 homologs homolog NOUN dti-1357 266 12 in in ADP dti-1357 266 13 deg deg PROPN dti-1357 266 14 × × PROPN dti-1357 266 15 interactors interactor NOUN dti-1357 266 16 × × PROPN dti-1357 266 17 drugbank drugbank NOUN dti-1357 266 18 hits/100 hits/100 PROPN dti-1357 266 19 . . PUNCT dti-1357 267 1 on on ADP dti-1357 267 2 their their PRON dti-1357 267 3 quantitative quantitative ADJ dti-1357 267 4 values value NOUN dti-1357 267 5 in in ADP dti-1357 267 6 order order NOUN dti-1357 267 7 to to PART dti-1357 267 8 decide decide VERB dti-1357 267 9 which which DET dti-1357 267 10 target target NOUN dti-1357 267 11 has have VERB dti-1357 267 12 a a DET dti-1357 267 13 higher high ADJ dti-1357 267 14 probability probability NOUN dti-1357 267 15 of of ADP dti-1357 267 16 being be AUX dti-1357 267 17 effective effective ADJ dti-1357 267 18 in in ADP dti-1357 267 19 laboratory laboratory NOUN dti-1357 267 20 experiments experiment NOUN dti-1357 267 21 . . PUNCT dti-1357 268 1 we we PRON dti-1357 268 2 ranked rank VERB dti-1357 268 3 the the DET dti-1357 268 4 putative putative ADJ dti-1357 268 5 therapeutic therapeutic ADJ dti-1357 268 6 targets target NOUN dti-1357 268 7 based base VERB dti-1357 268 8 on on ADP dti-1357 268 9 the the DET dti-1357 268 10 number number NOUN dti-1357 268 11 of of ADP dti-1357 268 12 homologs homolog NOUN dti-1357 268 13 found find VERB dti-1357 268 14 in in ADP dti-1357 268 15 deg deg PROPN dti-1357 268 16 , , PUNCT dti-1357 268 17 the the DET dti-1357 268 18 number number NOUN dti-1357 268 19 of of ADP dti-1357 268 20 interactors interactor NOUN dti-1357 268 21 of of ADP dti-1357 268 22 the the DET dti-1357 268 23 target target NOUN dti-1357 268 24 protein protein NOUN dti-1357 268 25 , , PUNCT dti-1357 268 26 and and CCONJ dti-1357 268 27 the the DET dti-1357 268 28 number number NOUN dti-1357 268 29 of of ADP dti-1357 268 30 drugs drug NOUN dti-1357 268 31 available available ADJ dti-1357 268 32 . . PUNCT dti-1357 269 1 the the DET dti-1357 269 2 ranking ranking NOUN dti-1357 269 3 of of ADP dti-1357 269 4 the the DET dti-1357 269 5 putative putative ADJ dti-1357 269 6 drug drug NOUN dti-1357 269 7 targets target NOUN dti-1357 269 8 is be AUX dti-1357 269 9 presented present VERB dti-1357 269 10 in in ADP dti-1357 269 11 table table NOUN dti-1357 269 12 4 4 NUM dti-1357 269 13 and and CCONJ dti-1357 269 14 showed show VERB dti-1357 269 15 that that SCONJ dti-1357 269 16 50s 50 NOUN dti-1357 269 17 ribosomal ribosomal NOUN dti-1357 269 18 protein protein NOUN dti-1357 269 19 l10 l10 NOUN dti-1357 269 20 has have VERB dti-1357 269 21 the the DET dti-1357 269 22 highest high ADJ dti-1357 269 23 potential potential NOUN dti-1357 269 24 to to PART dti-1357 269 25 be be AUX dti-1357 269 26 an an DET dti-1357 269 27 effective effective ADJ dti-1357 269 28 therapeutic therapeutic ADJ dti-1357 269 29 target target NOUN dti-1357 269 30 . . PUNCT dti-1357 270 1 cytidylate cytidylate PROPN dti-1357 270 2 kinase kinase PROPN dti-1357 270 3 , , PUNCT dti-1357 270 4 50s 50 NOUN dti-1357 270 5 ribosomal ribosomal NOUN dti-1357 270 6 protein protein NOUN dti-1357 270 7 l32 l32 NOUN dti-1357 270 8 , , PUNCT dti-1357 270 9 and and CCONJ dti-1357 270 10 putative putative ADJ dti-1357 270 11 nicotinate nicotinate ADJ dti-1357 270 12 - - PUNCT dti-1357 270 13 nucleotide nucleotide NOUN dti-1357 270 14 adenylyl adenylyl NOUN dti-1357 270 15 transferase transferase NOUN dti-1357 270 16 also also ADV dti-1357 270 17 fall fall VERB dti-1357 270 18 in in ADP dti-1357 270 19 the the DET dti-1357 270 20 group group NOUN dti-1357 270 21 of of ADP dti-1357 270 22 top top ADJ dti-1357 270 23 five five NUM dti-1357 270 24 putative putative ADJ dti-1357 270 25 therapeutic therapeutic ADJ dti-1357 270 26 targets target NOUN dti-1357 270 27 . . PUNCT dti-1357 271 1 discussion discussion NOUN dti-1357 271 2 the the DET dti-1357 271 3 increasing increase VERB dti-1357 271 4 trend trend NOUN dti-1357 271 5 of of ADP dti-1357 271 6 bacterial bacterial ADJ dti-1357 271 7 resistance resistance NOUN dti-1357 271 8 to to ADP dti-1357 271 9 antibiotics antibiotic NOUN dti-1357 271 10 is be AUX dti-1357 271 11 posing pose VERB dti-1357 271 12 an an DET dti-1357 271 13 imminent imminent ADJ dti-1357 271 14 public public ADJ dti-1357 271 15 health health NOUN dti-1357 271 16 concern concern NOUN dti-1357 271 17 . . PUNCT dti-1357 272 1 researchers researcher NOUN dti-1357 272 2 around around ADP dti-1357 272 3 the the DET dti-1357 272 4 world world NOUN dti-1357 272 5 are be AUX dti-1357 272 6 giving give VERB dti-1357 272 7 attention attention NOUN dti-1357 272 8 to to PART dti-1357 272 9 find find VERB dti-1357 272 10 new new ADJ dti-1357 272 11 drug drug NOUN dti-1357 272 12 targets target NOUN dti-1357 272 13 so so SCONJ dti-1357 272 14 that that SCONJ dti-1357 272 15 bacterial bacterial ADJ dti-1357 272 16 infections infection NOUN dti-1357 272 17 can can AUX dti-1357 272 18 be be AUX dti-1357 272 19 prevented prevent VERB dti-1357 272 20 . . PUNCT dti-1357 273 1 a a DET dti-1357 273 2 vast vast ADJ dti-1357 273 3 array array NOUN dti-1357 273 4 of of ADP dti-1357 273 5 omics omics PROPN dti-1357 273 6 data datum NOUN dti-1357 273 7 and and CCONJ dti-1357 273 8 the the DET dti-1357 273 9 availability availability NOUN dti-1357 273 10 of of ADP dti-1357 273 11 various various ADJ dti-1357 273 12 computational computational ADJ dti-1357 273 13 tools tool NOUN dti-1357 273 14 have have AUX dti-1357 273 15 speeded speed VERB dti-1357 273 16 up up ADP dti-1357 273 17 the the DET dti-1357 273 18 therapeutic therapeutic ADJ dti-1357 273 19 target target NOUN dti-1357 273 20 identification identification NOUN dti-1357 273 21 process process NOUN dti-1357 273 22 . . PUNCT dti-1357 274 1 the the DET dti-1357 274 2 potential potential NOUN dti-1357 274 3 of of ADP dti-1357 274 4 a a DET dti-1357 274 5 protein protein NOUN dti-1357 274 6 to to PART dti-1357 274 7 be be AUX dti-1357 274 8 a a DET dti-1357 274 9 therapeutic therapeutic ADJ dti-1357 274 10 target target NOUN dti-1357 274 11 depends depend VERB dti-1357 274 12 on on ADP dti-1357 274 13 two two NUM dti-1357 274 14 factors factor NOUN dti-1357 274 15 , , PUNCT dti-1357 274 16 essentiality essentiality NOUN dti-1357 274 17 and and CCONJ dti-1357 274 18 absence absence NOUN dti-1357 274 19 in in ADP dti-1357 274 20 the the DET dti-1357 274 21 host host NOUN dti-1357 274 22 . . PUNCT dti-1357 275 1 essential essential ADJ dti-1357 275 2 proteins protein NOUN dti-1357 275 3 are be AUX dti-1357 275 4 required require VERB dti-1357 275 5 for for ADP dti-1357 275 6 bacterial bacterial ADJ dti-1357 275 7 survival survival NOUN dti-1357 275 8 and and CCONJ dti-1357 275 9 blocking block VERB dti-1357 275 10 them they PRON dti-1357 275 11 inhibits inhibit VERB dti-1357 275 12 bacterial bacterial ADJ dti-1357 275 13 growth growth NOUN dti-1357 275 14 . . PUNCT dti-1357 276 1 non non ADJ dti-1357 276 2 - - ADJ dti-1357 276 3 homologous homologous ADJ dti-1357 276 4 proteins protein NOUN dti-1357 276 5 are be AUX dti-1357 276 6 preferred prefer VERB dti-1357 276 7 because because SCONJ dti-1357 276 8 they they PRON dti-1357 276 9 reduce reduce VERB dti-1357 276 10 the the DET dti-1357 276 11 probability probability NOUN dti-1357 276 12 of of ADP dti-1357 276 13 side side NOUN dti-1357 276 14 effects effect NOUN dti-1357 276 15 . . PUNCT dti-1357 277 1 in in ADP dti-1357 277 2 this this DET dti-1357 277 3 study study NOUN dti-1357 277 4 , , PUNCT dti-1357 277 5 we we PRON dti-1357 277 6 extracted extract VERB dti-1357 277 7 metabolic metabolic NOUN dti-1357 277 8 data datum NOUN dti-1357 277 9 from from ADP dti-1357 277 10 kegg kegg NOUN dti-1357 277 11 database database NOUN dti-1357 277 12 and and CCONJ dti-1357 277 13 used use VERB dti-1357 277 14 different different ADJ dti-1357 277 15 bioinformatics bioinformatic NOUN dti-1357 277 16 and and CCONJ dti-1357 277 17 computational computational ADJ dti-1357 277 18 databases database NOUN dti-1357 277 19 and and CCONJ dti-1357 277 20 tools tool NOUN dti-1357 277 21 for for ADP dti-1357 277 22 the the DET dti-1357 277 23 identification identification NOUN dti-1357 277 24 of of ADP dti-1357 277 25 appropriate appropriate ADJ dti-1357 277 26 therapeutic therapeutic ADJ dti-1357 277 27 targets target NOUN dti-1357 277 28 of of ADP dti-1357 277 29 m. m. NOUN dti-1357 277 30 hominis hominis PROPN dti-1357 277 31 . . PUNCT dti-1357 278 1 systematic systematic ADJ dti-1357 278 2 computational computational ADJ dti-1357 278 3 analyses analysis NOUN dti-1357 278 4 revealed reveal VERB dti-1357 278 5 57 57 NUM dti-1357 278 6 possible possible ADJ dti-1357 278 7 drug drug NOUN dti-1357 278 8 targets target NOUN dti-1357 278 9 in in ADP dti-1357 278 10 m. m. NOUN dti-1357 278 11 hominis homini NOUN dti-1357 278 12 ; ; PUNCT dti-1357 278 13 among among ADP dti-1357 278 14 them they PRON dti-1357 278 15 16 16 NUM dti-1357 278 16 are be AUX dti-1357 278 17 druggable druggable ADJ dti-1357 278 18 targets target NOUN dti-1357 278 19 , , PUNCT dti-1357 278 20 which which PRON dti-1357 278 21 have have VERB dti-1357 278 22 homologs homolog NOUN dti-1357 278 23 in in ADP dti-1357 278 24 drugbank drugbank NOUN dti-1357 278 25 . . PUNCT dti-1357 279 1 we we PRON dti-1357 279 2 further far ADV dti-1357 279 3 utilized utilize VERB dti-1357 279 4 different different ADJ dti-1357 279 5 drug drug NOUN dti-1357 279 6 prioritization prioritization NOUN dti-1357 279 7 parameters parameter NOUN dti-1357 279 8 to to PART dti-1357 279 9 make make VERB dti-1357 279 10 a a DET dti-1357 279 11 short short ADJ dti-1357 279 12 list list NOUN dti-1357 279 13 of of ADP dti-1357 279 14 potential potential ADJ dti-1357 279 15 drug drug NOUN dti-1357 279 16 and and CCONJ dti-1357 279 17 vaccine vaccine NOUN dti-1357 279 18 targets target NOUN dti-1357 279 19 . . PUNCT dti-1357 280 1 predicted predict VERB dti-1357 280 2 drug drug NOUN dti-1357 280 3 targets target NOUN dti-1357 280 4 belong belong VERB dti-1357 280 5 to to ADP dti-1357 280 6 a a DET dti-1357 280 7 diverse diverse ADJ dti-1357 280 8 range range NOUN dti-1357 280 9 of of ADP dti-1357 280 10 cellular cellular ADJ dti-1357 280 11 activity activity NOUN dti-1357 280 12 and and CCONJ dti-1357 280 13 fall fall VERB dti-1357 280 14 mostly mostly ADV dti-1357 280 15 into into ADP dti-1357 280 16 ribosome ribosome ADJ dti-1357 280 17 synthesis synthesis NOUN dti-1357 280 18 , , PUNCT dti-1357 280 19 pyrimidine pyrimidine NOUN dti-1357 280 20 metabolism metabolism NOUN dti-1357 280 21 , , PUNCT dti-1357 280 22 homologous homologous ADJ dti-1357 280 23 recombination recombination NOUN dti-1357 280 24 , , PUNCT dti-1357 280 25 dna dna NOUN dti-1357 280 26 replication replication NOUN dti-1357 280 27 , , PUNCT dti-1357 280 28 and and CCONJ dti-1357 280 29 abc abc PROPN dti-1357 280 30 transporter transporter NOUN dti-1357 280 31 pathways pathway NOUN dti-1357 280 32 ( ( PUNCT dti-1357 280 33 fig fig NOUN dti-1357 280 34 . . PUNCT dti-1357 280 35 3 3 NUM dti-1357 280 36 ) ) PUNCT dti-1357 280 37 . . PUNCT dti-1357 281 1 the the DET dti-1357 281 2 assembly assembly NOUN dti-1357 281 3 of of ADP dti-1357 281 4 bacterial bacterial ADJ dti-1357 281 5 ribosomes ribosome NOUN dti-1357 281 6 has have AUX dti-1357 281 7 been be AUX dti-1357 281 8 considered consider VERB dti-1357 281 9 prominently prominently ADV dti-1357 281 10 as as ADP dti-1357 281 11 a a DET dti-1357 281 12 potential potential ADJ dti-1357 281 13 target target NOUN dti-1357 281 14 for for ADP dti-1357 281 15 antibacterial antibacterial ADJ dti-1357 281 16 drugs.43 drugs.43 NOUN dti-1357 281 17 we we PRON dti-1357 281 18 identified identify VERB dti-1357 281 19 16 16 NUM dti-1357 281 20 potential potential ADJ dti-1357 281 21 drug drug NOUN dti-1357 281 22 targets target NOUN dti-1357 281 23 from from ADP dti-1357 281 24 the the DET dti-1357 281 25 ribosome ribosome NOUN dti-1357 281 26 synthesis synthesis NOUN dti-1357 281 27 and and CCONJ dti-1357 281 28 assembly assembly NOUN dti-1357 281 29 pathway pathway NOUN dti-1357 281 30 . . PUNCT dti-1357 282 1 among among ADP dti-1357 282 2 them they PRON dti-1357 282 3 , , PUNCT dti-1357 282 4 two two NUM dti-1357 282 5 are be AUX dti-1357 282 6 druggable druggable ADJ dti-1357 282 7 targets target NOUN dti-1357 282 8 that that PRON dti-1357 282 9 include include VERB dti-1357 282 10 50s 50 NOUN dti-1357 282 11 ribosomal ribosomal NOUN dti-1357 282 12 protein protein NOUN dti-1357 282 13 l10 l10 NOUN dti-1357 282 14 and and CCONJ dti-1357 282 15 l32 l32 PROPN dti-1357 282 16 . . PUNCT dti-1357 283 1 50s 50 NOUN dti-1357 283 2 ribosomal ribosomal NOUN dti-1357 283 3 protein protein NOUN dti-1357 283 4 l10 l10 NOUN dti-1357 283 5 interacting interact VERB dti-1357 283 6 with with ADP dti-1357 283 7 acidic acidic PROPN dti-1357 283 8 l7 l7 PROPN dti-1357 283 9 / / SYM dti-1357 283 10 l12 l12 NOUN dti-1357 283 11 proteins protein NOUN dti-1357 283 12 constitutes constitute VERB dti-1357 283 13 the the DET dti-1357 283 14 ribosomal ribosomal NOUN dti-1357 283 15 stalk stalk NOUN dti-1357 283 16 . . PUNCT dti-1357 284 1 this this DET dti-1357 284 2 stalk stalk NOUN dti-1357 284 3 is be AUX dti-1357 284 4 involved involve VERB dti-1357 284 5 in in ADP dti-1357 284 6 the the DET dti-1357 284 7 binding binding NOUN dti-1357 284 8 of of ADP dti-1357 284 9 elongation elongation NOUN dti-1357 284 10 factors factor NOUN dti-1357 284 11 ef ef PROPN dti-1357 284 12 - - PROPN dti-1357 284 13 tu tu PROPN dti-1357 284 14 and and CCONJ dti-1357 284 15 ef ef PROPN dti-1357 284 16 - - PROPN dti-1357 284 17 g g PROPN dti-1357 284 18 and and CCONJ dti-1357 284 19 plays play VERB dti-1357 284 20 a a DET dti-1357 284 21 crucial crucial ADJ dti-1357 284 22 role role NOUN dti-1357 284 23 in in ADP dti-1357 284 24 activating activate VERB dti-1357 284 25 the the DET dti-1357 284 26 gtpase gtpase NOUN dti-1357 284 27 center center NOUN dti-1357 284 28 . . PUNCT dti-1357 285 1 this this DET dti-1357 285 2 target target NOUN dti-1357 285 3 is be AUX dti-1357 285 4 highly highly ADV dti-1357 285 5 similar similar ADJ dti-1357 285 6 to to ADP dti-1357 285 7 an an DET dti-1357 285 8 already already ADV dti-1357 285 9 available available ADJ dti-1357 285 10 drug drug NOUN dti-1357 285 11 target target NOUN dti-1357 285 12 with with ADP dti-1357 285 13 five five NUM dti-1357 285 14 fda fda PROPN dti-1357 285 15 - - PUNCT dti-1357 285 16 approved approve VERB dti-1357 285 17 drugs drug NOUN dti-1357 285 18 used use VERB dti-1357 285 19 to to PART dti-1357 285 20 control control VERB dti-1357 285 21 shigella shigella ADJ dti-1357 285 22 infection infection NOUN dti-1357 285 23 . . PUNCT dti-1357 286 1 our our PRON dti-1357 286 2 http://www.la-press.com http://www.la-press.com X dti-1357 286 3 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1357 286 4 parvege parvege PROPN dti-1357 286 5 et et PROPN dti-1357 286 6 al al PROPN dti-1357 286 7 60 60 NUM dti-1357 286 8 drug drug NOUN dti-1357 286 9 target target NOUN dti-1357 286 10 insights insight NOUN dti-1357 286 11 2014:8 2014:8 NUM dti-1357 286 12 0 0 NUM dti-1357 286 13 5 5 NUM dti-1357 286 14 10 10 NUM dti-1357 286 15 15 15 NUM dti-1357 286 16 20 20 NUM dti-1357 286 17 25 25 NUM dti-1357 286 18 30 30 NUM dti-1357 286 19 others other NOUN dti-1357 286 20 ( ( PUNCT dti-1357 286 21 24 24 NUM dti-1357 286 22 pathways pathway NOUN dti-1357 286 23 ) ) PUNCT dti-1357 286 24 pentose pentose NOUN dti-1357 286 25 phosphate phosphate NOUN dti-1357 286 26 pathway pathway NOUN dti-1357 286 27 protein protein NOUN dti-1357 286 28 export export NOUN dti-1357 286 29 microbial microbial ADJ dti-1357 286 30 metabolism metabolism NOUN dti-1357 286 31 in in ADP dti-1357 286 32 diverse diverse ADJ dti-1357 286 33 … … PUNCT dti-1357 286 34 biosynthesis biosynthesis NOUN dti-1357 286 35 of of ADP dti-1357 286 36 amino amino ADJ dti-1357 286 37 acids acid NOUN dti-1357 286 38 biosynthesis biosynthesis NOUN dti-1357 286 39 of of ADP dti-1357 286 40 secondary secondary ADJ dti-1357 286 41 metabolites metabolite NOUN dti-1357 286 42 abc abc PROPN dti-1357 286 43 transporters transporter NOUN dti-1357 286 44 homologous homologous ADJ dti-1357 286 45 recombination recombination NOUN dti-1357 286 46 ribosome ribosome NOUN dti-1357 286 47 number number NOUN dti-1357 286 48 of of ADP dti-1357 286 49 proteins protein NOUN dti-1357 286 50 figure figure NOUN dti-1357 286 51 3 3 NUM dti-1357 286 52 . . PUNCT dti-1357 286 53 distribution distribution NOUN dti-1357 286 54 of of ADP dti-1357 286 55 putative putative ADJ dti-1357 286 56 therapeutic therapeutic ADJ dti-1357 286 57 targets target NOUN dti-1357 286 58 in in ADP dti-1357 286 59 their their PRON dti-1357 286 60 associated associated ADJ dti-1357 286 61 pathways pathway NOUN dti-1357 286 62 . . PUNCT dti-1357 287 1 the the DET dti-1357 287 2 percentage percentage NOUN dti-1357 287 3 distribution distribution NOUN dti-1357 287 4 of of ADP dti-1357 287 5 other other ADJ dti-1357 287 6 pathways pathway NOUN dti-1357 287 7 ranges range VERB dti-1357 287 8 from from ADP dti-1357 287 9 0 0 NUM dti-1357 287 10 to to ADP dti-1357 287 11 4.5 4.5 NUM dti-1357 287 12 . . PUNCT dti-1357 288 1 study study NOUN dti-1357 288 2 revealed reveal VERB dti-1357 288 3 that that SCONJ dti-1357 288 4 50s 50 NOUN dti-1357 288 5 ribosomal ribosomal NOUN dti-1357 288 6 protein protein NOUN dti-1357 288 7 l10 l10 NOUN dti-1357 288 8 holds hold VERB dti-1357 288 9 the the DET dti-1357 288 10 highest high ADJ dti-1357 288 11 promise promise NOUN dti-1357 288 12 to to PART dti-1357 288 13 be be AUX dti-1357 288 14 an an DET dti-1357 288 15 effective effective ADJ dti-1357 288 16 drug drug NOUN dti-1357 288 17 target target NOUN dti-1357 288 18 ( ( PUNCT dti-1357 288 19 table table NOUN dti-1357 288 20 4 4 NUM dti-1357 288 21 ) ) PUNCT dti-1357 288 22 . . PUNCT dti-1357 289 1 hence hence ADV dti-1357 289 2 , , PUNCT dti-1357 289 3 the the DET dti-1357 289 4 potential potential NOUN dti-1357 289 5 of of ADP dti-1357 289 6 it it PRON dti-1357 289 7 as as ADP dti-1357 289 8 a a DET dti-1357 289 9 drug drug NOUN dti-1357 289 10 target target NOUN dti-1357 289 11 remains remain VERB dti-1357 289 12 open open ADJ dti-1357 289 13 for for ADP dti-1357 289 14 experimental experimental ADJ dti-1357 289 15 validation validation NOUN dti-1357 289 16 . . PUNCT dti-1357 290 1 50s 50 NOUN dti-1357 290 2 ribosomal ribosomal NOUN dti-1357 290 3 protein protein NOUN dti-1357 290 4 l32 l32 NOUN dti-1357 290 5 is be AUX dti-1357 290 6 a a DET dti-1357 290 7 structural structural ADJ dti-1357 290 8 constituent constituent NOUN dti-1357 290 9 of of ADP dti-1357 290 10 ribosomes ribosome NOUN dti-1357 290 11 . . PUNCT dti-1357 291 1 this this DET dti-1357 291 2 target target NOUN dti-1357 291 3 was be AUX dti-1357 291 4 found find VERB dti-1357 291 5 to to PART dti-1357 291 6 have have VERB dti-1357 291 7 a a DET dti-1357 291 8 homologous homologous ADJ dti-1357 291 9 target target NOUN dti-1357 291 10 in in ADP dti-1357 291 11 drugbank drugbank NOUN dti-1357 291 12 for for ADP dti-1357 291 13 an an DET dti-1357 291 14 fda fda PROPN dti-1357 291 15 - - PUNCT dti-1357 291 16 approved approve VERB dti-1357 291 17 drug drug NOUN dti-1357 291 18 called call VERB dti-1357 291 19 troleandomycin troleandomycin NOUN dti-1357 291 20 . . PUNCT dti-1357 292 1 however however ADV dti-1357 292 2 , , PUNCT dti-1357 292 3 m. m. NOUN dti-1357 292 4 hominis hominis PROPN dti-1357 292 5 is be AUX dti-1357 292 6 intrinsically intrinsically ADV dti-1357 292 7 resistant resistant ADJ dti-1357 292 8 to to ADP dti-1357 292 9 this this DET dti-1357 292 10 antibiotic antibiotic NOUN dti-1357 292 11 because because SCONJ dti-1357 292 12 of of ADP dti-1357 292 13 mutations mutation NOUN dti-1357 292 14 in in ADP dti-1357 292 15 23s 23s PROPN dti-1357 292 16 rrna rrna PROPN dti-1357 292 17 , , PUNCT dti-1357 292 18 which which PRON dti-1357 292 19 has have AUX dti-1357 292 20 stimulated stimulate VERB dti-1357 292 21 the the DET dti-1357 292 22 search search NOUN dti-1357 292 23 for for ADP dti-1357 292 24 other other ADJ dti-1357 292 25 drug drug NOUN dti-1357 292 26 targets.10 targets.10 PROPN dti-1357 292 27 de de X dti-1357 292 28 novo novo PROPN dti-1357 292 29 nucleotide nucleotide ADJ dti-1357 292 30 synthesis synthesis NOUN dti-1357 292 31 is be AUX dti-1357 292 32 crucial crucial ADJ dti-1357 292 33 for for ADP dti-1357 292 34 the the DET dti-1357 292 35 successful successful ADJ dti-1357 292 36 growth growth NOUN dti-1357 292 37 of of ADP dti-1357 292 38 bacteria bacteria NOUN dti-1357 292 39 in in ADP dti-1357 292 40 human human ADJ dti-1357 292 41 blood.44 blood.44 NOUN dti-1357 292 42 nucleotides nucleotide NOUN dti-1357 292 43 synthesized synthesize VERB dti-1357 292 44 in in ADP dti-1357 292 45 purine purine NOUN dti-1357 292 46 and and CCONJ dti-1357 292 47 pyrimidine pyrimidine NOUN dti-1357 292 48 metabolic metabolic NOUN dti-1357 292 49 pathways pathway NOUN dti-1357 292 50 are be AUX dti-1357 292 51 important important ADJ dti-1357 292 52 substrates substrate NOUN dti-1357 292 53 not not PART dti-1357 292 54 only only ADV dti-1357 292 55 for for ADP dti-1357 292 56 dna dna ADJ dti-1357 292 57 synthesis synthesis NOUN dti-1357 292 58 but but CCONJ dti-1357 292 59 also also ADV dti-1357 292 60 for for ADP dti-1357 292 61 dna dna PROPN dti-1357 292 62 repair repair NOUN dti-1357 292 63 . . PUNCT dti-1357 293 1 we we PRON dti-1357 293 2 have have AUX dti-1357 293 3 found find VERB dti-1357 293 4 five five NUM dti-1357 293 5 and and CCONJ dti-1357 293 6 eight eight NUM dti-1357 293 7 drug drug NOUN dti-1357 293 8 targets target NOUN dti-1357 293 9 for for ADP dti-1357 293 10 purine purine NOUN dti-1357 293 11 and and CCONJ dti-1357 293 12 pyrimidine pyrimidine NOUN dti-1357 293 13 metabolism metabolism NOUN dti-1357 293 14 , , PUNCT dti-1357 293 15 respectively respectively ADV dti-1357 293 16 . . PUNCT dti-1357 294 1 dna dna PROPN dti-1357 294 2 polymerase polymerase NOUN dti-1357 295 1 i i PRON dti-1357 295 2 ( ( PUNCT dti-1357 295 3 pol pol PROPN dti-1357 295 4 i i PROPN dti-1357 295 5 ) ) PUNCT dti-1357 295 6 and and CCONJ dti-1357 295 7 dna dna NOUN dti-1357 295 8 - - PUNCT dti-1357 295 9 directed direct VERB dti-1357 295 10 rna rna NOUN dti-1357 295 11 polymerase polymerase NOUN dti-1357 295 12 subunit subunit NOUN dti-1357 295 13 alpha alpha NOUN dti-1357 295 14 ( ( PUNCT dti-1357 295 15 rpoa rpoa PROPN dti-1357 295 16 ) ) PUNCT dti-1357 295 17 , , PUNCT dti-1357 295 18 which which PRON dti-1357 295 19 is be AUX dti-1357 295 20 involved involve VERB dti-1357 295 21 in in ADP dti-1357 295 22 nucleotide nucleotide ADJ dti-1357 295 23 metabolism metabolism NOUN dti-1357 295 24 as as ADV dti-1357 295 25 well well ADV dti-1357 295 26 as as ADP dti-1357 295 27 other other ADJ dti-1357 295 28 important important ADJ dti-1357 295 29 metabolic metabolic NOUN dti-1357 295 30 pathways pathway NOUN dti-1357 295 31 , , PUNCT dti-1357 295 32 have have VERB dti-1357 295 33 homologs homolog NOUN dti-1357 295 34 in in ADP dti-1357 295 35 drugbank drugbank NOUN dti-1357 295 36 . . PUNCT dti-1357 296 1 azelaic azelaic PROPN dti-1357 296 2 acid acid PROPN dti-1357 296 3 , , PUNCT dti-1357 296 4 an an DET dti-1357 296 5 approved approve VERB dti-1357 296 6 fda fda PROPN dti-1357 296 7 drug drug NOUN dti-1357 296 8 , , PUNCT dti-1357 296 9 can can AUX dti-1357 296 10 be be AUX dti-1357 296 11 used use VERB dti-1357 296 12 to to PART dti-1357 296 13 treat treat VERB dti-1357 296 14 m. m. NOUN dti-1357 296 15 hominis hominis PROPN dti-1357 296 16 infection infection NOUN dti-1357 296 17 by by ADP dti-1357 296 18 inhibiting inhibit VERB dti-1357 296 19 the the DET dti-1357 296 20 activity activity NOUN dti-1357 296 21 of of ADP dti-1357 296 22 pol pol PROPN dti-1357 296 23 i. i. NOUN dti-1357 296 24 this this DET dti-1357 296 25 drug drug NOUN dti-1357 296 26 is be AUX dti-1357 296 27 currently currently ADV dti-1357 296 28 being be AUX dti-1357 296 29 used use VERB dti-1357 296 30 as as ADP dti-1357 296 31 an an DET dti-1357 296 32 inhibitor inhibitor NOUN dti-1357 296 33 of of ADP dti-1357 296 34 pol pol PROPN dti-1357 296 35 i i PROPN dti-1357 296 36 in in ADP dti-1357 296 37 escherichia escherichia NOUN dti-1357 296 38 coli coli NOUN dti-1357 296 39 . . PUNCT dti-1357 297 1 rpoa rpoa NOUN dti-1357 297 2 activity activity NOUN dti-1357 297 3 can can AUX dti-1357 297 4 be be AUX dti-1357 297 5 blocked block VERB dti-1357 297 6 by by ADP dti-1357 297 7 an an DET dti-1357 297 8 approved approve VERB dti-1357 297 9 drug drug NOUN dti-1357 297 10 , , PUNCT dti-1357 297 11 rifabutin rifabutin NOUN dti-1357 297 12 , , PUNCT dti-1357 297 13 which which PRON dti-1357 297 14 is be AUX dti-1357 297 15 highly highly ADV dti-1357 297 16 specific specific ADJ dti-1357 297 17 to to ADP dti-1357 297 18 bacterial bacterial ADJ dti-1357 297 19 rna rna NOUN dti-1357 297 20 polymerase polymerase NOUN dti-1357 297 21 . . PUNCT dti-1357 298 1 in in ADP dti-1357 298 2 the the DET dti-1357 298 3 last last ADJ dti-1357 298 4 few few ADJ dti-1357 298 5 years year NOUN dti-1357 298 6 , , PUNCT dti-1357 298 7 aminoacyl aminoacyl PROPN dti-1357 298 8 - - PUNCT dti-1357 298 9 trna trna NOUN dti-1357 298 10 synthetases synthetase NOUN dti-1357 298 11 ( ( PUNCT dti-1357 298 12 aars aar NOUN dti-1357 298 13 ) ) PUNCT dti-1357 298 14 have have AUX dti-1357 298 15 drawn draw VERB dti-1357 298 16 much much ADJ dti-1357 298 17 attention attention NOUN dti-1357 298 18 as as ADP dti-1357 298 19 therapeutic therapeutic ADJ dti-1357 298 20 targets target NOUN dti-1357 298 21 because because SCONJ dti-1357 298 22 of of ADP dti-1357 298 23 their their PRON dti-1357 298 24 crucial crucial ADJ dti-1357 298 25 roles role NOUN dti-1357 298 26 in in ADP dti-1357 298 27 protein protein NOUN dti-1357 298 28 synthesis synthesis NOUN dti-1357 298 29 and and CCONJ dti-1357 298 30 conservation conservation NOUN dti-1357 298 31 across across ADP dti-1357 298 32 different different ADJ dti-1357 298 33 pathogens.45 pathogens.45 NOUN dti-1357 298 34 here here ADV dti-1357 298 35 , , PUNCT dti-1357 298 36 we we PRON dti-1357 298 37 highlighted highlight VERB dti-1357 298 38 phenylalanyl phenylalanyl PROPN dti-1357 298 39 - - PUNCT dti-1357 298 40 trna trna ADJ dti-1357 298 41 synthetase synthetase NOUN dti-1357 298 42 subunit subunit NOUN dti-1357 298 43 beta beta NOUN dti-1357 298 44 ( ( PUNCT dti-1357 298 45 phet phet NOUN dti-1357 298 46 ) ) PUNCT dti-1357 298 47 as as ADP dti-1357 298 48 a a DET dti-1357 298 49 therapeutic therapeutic ADJ dti-1357 298 50 target target NOUN dti-1357 298 51 , , PUNCT dti-1357 298 52 which which PRON dti-1357 298 53 showed show VERB dti-1357 298 54 considerable considerable ADJ dti-1357 298 55 homology homology NOUN dti-1357 298 56 with with ADP dti-1357 298 57 a a DET dti-1357 298 58 target target NOUN dti-1357 298 59 in in ADP dti-1357 298 60 drugbank drugbank NOUN dti-1357 298 61 database database NOUN dti-1357 298 62 . . PUNCT dti-1357 299 1 phenyl phenyl NOUN dti-1357 299 2 - - PUNCT dti-1357 299 3 thiazolylurea thiazolylurea NOUN dti-1357 299 4 - - PUNCT dti-1357 299 5 sulfonamide sulfonamide NOUN dti-1357 299 6 , , PUNCT dti-1357 299 7 a a DET dti-1357 299 8 successful successful ADJ dti-1357 299 9 inhibitor inhibitor NOUN dti-1357 299 10 of of ADP dti-1357 299 11 phenylalanyl phenylalanyl ADJ dti-1357 299 12 - - PUNCT dti-1357 299 13 trna trna NOUN dti-1357 299 14 synthetase synthetase NOUN dti-1357 299 15 ( ( PUNCT dti-1357 299 16 phe phe NOUN dti-1357 299 17 - - PUNCT dti-1357 299 18 rs rs NOUN dti-1357 299 19 ) ) PUNCT dti-1357 299 20 , , PUNCT dti-1357 299 21     SPACE dti-1357 299 22 can can AUX dti-1357 299 23 be be AUX dti-1357 299 24 tested test VERB dti-1357 299 25 in in ADP dti-1357 299 26 the the DET dti-1357 299 27 laboratory laboratory NOUN dti-1357 299 28 to to PART dti-1357 299 29 determine determine VERB dti-1357 299 30 its its PRON dti-1357 299 31 efficacy efficacy NOUN dti-1357 299 32 against against ADP dti-1357 299 33 m. m. NOUN dti-1357 299 34 hominis.46 hominis.46 PROPN dti-1357 299 35 glycolysis glycolysis NOUN dti-1357 299 36 / / SYM dti-1357 299 37 gluconeogenesis gluconeogenesis NOUN dti-1357 299 38 is be AUX dti-1357 299 39 perceived perceive VERB dti-1357 299 40 as as ADP dti-1357 299 41 a a DET dti-1357 299 42 promising promising ADJ dti-1357 299 43 target target NOUN dti-1357 299 44 for for ADP dti-1357 299 45 new new ADJ dti-1357 299 46 drugs drug NOUN dti-1357 299 47 against against ADP dti-1357 299 48 bacterial bacterial ADJ dti-1357 299 49 pathogens pathogen NOUN dti-1357 299 50 because because SCONJ dti-1357 299 51 many many ADJ dti-1357 299 52 of of ADP dti-1357 299 53 the the DET dti-1357 299 54 proteins protein NOUN dti-1357 299 55 involved involve VERB dti-1357 299 56 in in ADP dti-1357 299 57 this this DET dti-1357 299 58 pathway pathway NOUN dti-1357 299 59 are be AUX dti-1357 299 60 significantly significantly ADV dti-1357 299 61 different different ADJ dti-1357 299 62 from from ADP dti-1357 299 63 human human ADJ dti-1357 299 64 proteins protein NOUN dti-1357 299 65 . . PUNCT dti-1357 300 1 here here ADV dti-1357 300 2 , , PUNCT dti-1357 300 3 we we PRON dti-1357 300 4 identified identify VERB dti-1357 300 5 two two NUM dti-1357 300 6 proteins protein NOUN dti-1357 300 7 of of ADP dti-1357 300 8 the the DET dti-1357 300 9 glycolytic glycolytic ADJ dti-1357 300 10 pathway pathway NOUN dti-1357 300 11 as as ADP dti-1357 300 12 potential potential ADJ dti-1357 300 13 therapeutic therapeutic ADJ dti-1357 300 14 targets target NOUN dti-1357 300 15 — — PUNCT dti-1357 300 16 one one NUM dti-1357 300 17 is be AUX dti-1357 300 18 fructose fructose NOUN dti-1357 300 19 - - PUNCT dti-1357 300 20 bisphosphate bisphosphate NOUN dti-1357 300 21 aldolase aldolase NOUN dti-1357 300 22 ( ( PUNCT dti-1357 300 23 fba fba PROPN dti-1357 300 24 ) ) PUNCT dti-1357 300 25 and and CCONJ dti-1357 300 26 the the DET dti-1357 300 27 other other ADJ dti-1357 300 28 is be AUX dti-1357 300 29 a a DET dti-1357 300 30 hypothetical hypothetical ADJ dti-1357 300 31 protein protein NOUN dti-1357 300 32 , , PUNCT dti-1357 300 33 mho_3810 mho_3810 PROPN dti-1357 300 34 , , PUNCT dti-1357 300 35     SPACE dti-1357 300 36 which which PRON dti-1357 300 37 is be AUX dti-1357 300 38 found find VERB dti-1357 300 39 to to PART dti-1357 300 40 have have VERB dti-1357 300 41 2,3 2,3 NUM dti-1357 300 42 - - PUNCT dti-1357 300 43 bisphosphoglycerate bisphosphoglycerate ADJ dti-1357 300 44 - - PUNCT dti-1357 300 45 independent independent ADJ dti-1357 300 46 phosphoglycerate phosphoglycerate NOUN dti-1357 300 47 mutase mutase NOUN dti-1357 300 48 ( ( PUNCT dti-1357 300 49 ipgm ipgm NOUN dti-1357 300 50 ) ) PUNCT dti-1357 300 51 activity activity NOUN dti-1357 300 52 . . PUNCT dti-1357 301 1 fba fba PROPN dti-1357 301 2 catalyses catalyse VERB dti-1357 301 3 an an DET dti-1357 301 4 important important ADJ dti-1357 301 5 reversible reversible ADJ dti-1357 301 6 reaction reaction NOUN dti-1357 301 7 required require VERB dti-1357 301 8 for for ADP dti-1357 301 9 both both CCONJ dti-1357 301 10 glycolysis glycolysis NOUN dti-1357 301 11 and and CCONJ dti-1357 301 12 gluconeogenesis.47 gluconeogenesis.47 NOUN dti-1357 301 13 previously previously ADV dti-1357 301 14 , , PUNCT dti-1357 301 15 this this DET dti-1357 301 16 enzyme enzyme NOUN dti-1357 301 17 has have AUX dti-1357 301 18 been be AUX dti-1357 301 19 reported report VERB dti-1357 301 20 as as ADP dti-1357 301 21 a a DET dti-1357 301 22 target target NOUN dti-1357 301 23 of of ADP dti-1357 301 24 antifungal antifungal ADJ dti-1357 301 25 and and CCONJ dti-1357 301 26 antiprotozoal antiprotozoal ADJ dti-1357 301 27 drugs drug NOUN dti-1357 301 28 . . PUNCT dti-1357 302 1 downregulation downregulation NOUN dti-1357 302 2 of of ADP dti-1357 302 3     SPACE dti-1357 302 4 ipgm ipgm NOUN dti-1357 302 5 using use VERB dti-1357 302 6 rnai rnai PROPN dti-1357 302 7 resulted result VERB dti-1357 302 8 in in ADP dti-1357 302 9 embryonic embryonic ADJ dti-1357 302 10 and and CCONJ dti-1357 302 11 larval larval NOUN dti-1357 302 12 lethality lethality NOUN dti-1357 302 13 in in ADP dti-1357 302 14 caenorhabditis caenorhabditis PROPN dti-1357 302 15 elegans.48 elegans.48 PROPN dti-1357 302 16 in in ADP dti-1357 302 17 addition addition NOUN dti-1357 302 18 to to ADP dti-1357 302 19 druggable druggable ADJ dti-1357 302 20 targets target NOUN dti-1357 302 21 , , PUNCT dti-1357 302 22 we we PRON dti-1357 302 23 have have AUX dti-1357 302 24 also also ADV dti-1357 302 25 identified identify VERB dti-1357 302 26 several several ADJ dti-1357 302 27 other other ADJ dti-1357 302 28 targets target NOUN dti-1357 302 29 that that PRON dti-1357 302 30 are be AUX dti-1357 302 31 involved involve VERB dti-1357 302 32 in in ADP dti-1357 302 33 crucial crucial ADJ dti-1357 302 34 bacterial bacterial ADJ dti-1357 302 35 metabolic metabolic NOUN dti-1357 302 36 pathways pathway NOUN dti-1357 302 37 . . PUNCT dti-1357 303 1 bacterial bacterial ADJ dti-1357 303 2 protein protein NOUN dti-1357 303 3 secretion secretion NOUN dti-1357 303 4 system system NOUN dti-1357 303 5 pathway pathway NOUN dti-1357 303 6 modulates modulate VERB dti-1357 303 7 biotic biotic ADJ dti-1357 303 8 association association NOUN dti-1357 303 9 as as ADV dti-1357 303 10 well well ADV dti-1357 303 11 as as ADP dti-1357 303 12 pathogenicity pathogenicity NOUN dti-1357 303 13 . . PUNCT dti-1357 304 1 therefore therefore ADV dti-1357 304 2 , , PUNCT dti-1357 304 3 proteins protein NOUN dti-1357 304 4 from from ADP dti-1357 304 5 the the DET dti-1357 304 6 bacterial bacterial ADJ dti-1357 304 7 secretion secretion NOUN dti-1357 304 8 system system NOUN dti-1357 304 9 were be AUX dti-1357 304 10 identified identify VERB dti-1357 304 11 as as ADP dti-1357 304 12 drug drug NOUN dti-1357 304 13 targets target NOUN dti-1357 304 14 in in ADP dti-1357 304 15 many many ADJ dti-1357 304 16 bacteria.49,50 bacteria.49,50 NOUN dti-1357 304 17 this this DET dti-1357 304 18 secretion secretion NOUN dti-1357 304 19 system system NOUN dti-1357 304 20 of of ADP dti-1357 304 21 m. m. NOUN dti-1357 304 22 hominis hominis PROPN dti-1357 304 23 includes include VERB dti-1357 304 24 eight eight NUM dti-1357 304 25 proteins protein NOUN dti-1357 304 26 . . PUNCT dti-1357 305 1 among among ADP dti-1357 305 2 them they PRON dti-1357 305 3 three three NUM dti-1357 305 4 have have AUX dti-1357 305 5 been be AUX dti-1357 305 6 proposed propose VERB dti-1357 305 7 as as ADP dti-1357 305 8 potential potential ADJ dti-1357 305 9 therapeutic therapeutic ADJ dti-1357 305 10 targets target NOUN dti-1357 305 11 in in ADP dti-1357 305 12 our our PRON dti-1357 305 13 study study NOUN dti-1357 305 14 . . PUNCT dti-1357 306 1 the the DET dti-1357 306 2 proposed proposed ADJ dti-1357 306 3 three three NUM dti-1357 306 4 targets target NOUN dti-1357 306 5 are be AUX dti-1357 306 6 secd secd NOUN dti-1357 306 7 , , PUNCT dti-1357 306 8 secy secy NOUN dti-1357 306 9 , , PUNCT dti-1357 306 10 and and CCONJ dti-1357 306 11 yidc yidc PROPN dti-1357 306 12 / / SYM dti-1357 306 13 oxa1 oxa1 PROPN dti-1357 306 14 family family NOUN dti-1357 306 15 membrane membrane NOUN dti-1357 306 16 proteins protein NOUN dti-1357 306 17 , , PUNCT dti-1357 306 18 and and CCONJ dti-1357 306 19 this this DET dti-1357 306 20 result result NOUN dti-1357 306 21 is be AUX dti-1357 306 22 consistent consistent ADJ dti-1357 306 23 with with ADP dti-1357 306 24 two two NUM dti-1357 306 25 previous previous ADJ dti-1357 306 26 studies.51,52 studies.51,52 NOUN dti-1357 306 27 extensive extensive ADJ dti-1357 306 28 research research NOUN dti-1357 306 29 is be AUX dti-1357 306 30 going go VERB dti-1357 306 31 on on ADP dti-1357 306 32 in in ADP dti-1357 306 33 the the DET dti-1357 306 34 development development NOUN dti-1357 306 35 of of ADP dti-1357 306 36 protein protein NOUN dti-1357 306 37 secretion secretion NOUN dti-1357 306 38 inhibitors inhibitor NOUN dti-1357 306 39 like like ADP dti-1357 306 40 salicylidene salicylidene NOUN dti-1357 306 41 acylhydrazides53 acylhydrazides53 ADJ dti-1357 306 42 and and CCONJ dti-1357 306 43 2 2 NUM dti-1357 306 44 - - PUNCT dti-1357 306 45 imino-5 imino-5 PROPN dti-1357 306 46 - - PUNCT dti-1357 306 47 arylidene arylidene NOUN dti-1357 306 48 thiazolidinone.54 thiazolidinone.54 PROPN dti-1357 306 49 earlier early ADJ dti-1357 306 50 studies study NOUN dti-1357 306 51 reported report VERB dti-1357 306 52 that that SCONJ dti-1357 306 53 abc abc PROPN dti-1357 306 54 transporters transporter NOUN dti-1357 306 55 play play VERB dti-1357 306 56 an an DET dti-1357 306 57 important important ADJ dti-1357 306 58 role role NOUN dti-1357 306 59 in in ADP dti-1357 306 60 bacterial bacterial ADJ dti-1357 306 61 physiological physiological ADJ dti-1357 306 62 processes process NOUN dti-1357 306 63 such such ADJ dti-1357 306 64 as as ADP dti-1357 306 65 the the DET dti-1357 306 66 import import NOUN dti-1357 306 67 of of ADP dti-1357 306 68 important important ADJ dti-1357 306 69 nutrients nutrient NOUN dti-1357 306 70 required require VERB dti-1357 306 71 for for ADP dti-1357 306 72 bacterial bacterial ADJ dti-1357 306 73 growth55 growth55 NOUN dti-1357 306 74 and and CCONJ dti-1357 306 75 export export NOUN dti-1357 306 76 of of ADP dti-1357 306 77 toxic toxic ADJ dti-1357 306 78 substances substance NOUN dti-1357 306 79 outside outside ADP dti-1357 306 80 of of ADP dti-1357 306 81 the the DET dti-1357 306 82 cell.56 cell.56 NOUN dti-1357 306 83 here here ADV dti-1357 306 84 , , PUNCT dti-1357 306 85 we we PRON dti-1357 306 86 have have AUX dti-1357 306 87 reported report VERB dti-1357 306 88 six six NUM dti-1357 306 89 abc abc PROPN dti-1357 306 90 transporters transporter NOUN dti-1357 306 91 as as ADP dti-1357 306 92 novel novel ADJ dti-1357 306 93 therapeutic therapeutic ADJ dti-1357 306 94 targets target NOUN dti-1357 306 95 . . PUNCT dti-1357 307 1 these these DET dti-1357 307 2 transporters transporter NOUN dti-1357 307 3 can can AUX dti-1357 307 4 be be AUX dti-1357 307 5 used use VERB dti-1357 307 6 for for ADP dti-1357 307 7 the the DET dti-1357 307 8 development development NOUN dti-1357 307 9 of of ADP dti-1357 307 10 antibacterial antibacterial ADJ dti-1357 307 11 vaccines.57 vaccines.57 NOUN dti-1357 307 12 conclusion conclusion NOUN dti-1357 307 13 this this DET dti-1357 307 14 study study NOUN dti-1357 307 15 has have AUX dti-1357 307 16 identified identify VERB dti-1357 307 17 several several ADJ dti-1357 307 18 proteins protein NOUN dti-1357 307 19 that that PRON dti-1357 307 20 can can AUX dti-1357 307 21 be be AUX dti-1357 307 22 targeted target VERB dti-1357 307 23 for for ADP dti-1357 307 24 effective effective ADJ dti-1357 307 25 drug drug NOUN dti-1357 307 26 development development NOUN dti-1357 307 27 . . PUNCT dti-1357 308 1 since since SCONJ dti-1357 308 2 some some PRON dti-1357 308 3 of of ADP dti-1357 308 4 the the DET dti-1357 308 5 identified identify VERB dti-1357 308 6 http://www.la-press.com http://www.la-press.com X dti-1357 308 7 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1357 308 8 identification identification NOUN dti-1357 308 9 of of ADP dti-1357 308 10 therapeutic therapeutic ADJ dti-1357 308 11 targets target NOUN dti-1357 308 12 in in ADP dti-1357 308 13 mycoplasma mycoplasma NOUN dti-1357 308 14 hominis hominis X dti-1357 308 15 61drug 61drug NUM dti-1357 308 16 target target NOUN dti-1357 308 17 insights insight VERB dti-1357 308 18 2014:8 2014:8 NUM dti-1357 308 19 drug drug NOUN dti-1357 308 20 targets target NOUN dti-1357 308 21 play play VERB dti-1357 308 22 important important ADJ dti-1357 308 23 roles role NOUN dti-1357 308 24 in in ADP dti-1357 308 25 metabolism metabolism NOUN dti-1357 308 26 , , PUNCT dti-1357 308 27 a a DET dti-1357 308 28 synchronized synchronize VERB dti-1357 308 29 approach approach NOUN dti-1357 308 30 to to PART dti-1357 308 31 develop develop VERB dti-1357 308 32 new new ADJ dti-1357 308 33 drugs drug NOUN dti-1357 308 34 would would AUX dti-1357 308 35 be be AUX dti-1357 308 36 promising promise VERB dti-1357 308 37 to to PART dti-1357 308 38 control control VERB dti-1357 308 39 m. m. NOUN dti-1357 308 40 hominis hominis PROPN dti-1357 308 41 infection infection NOUN dti-1357 308 42 . . PUNCT dti-1357 309 1 in in ADP dti-1357 309 2 addition addition NOUN dti-1357 309 3 , , PUNCT dti-1357 309 4 results result NOUN dti-1357 309 5 of of ADP dti-1357 309 6 this this DET dti-1357 309 7 study study NOUN dti-1357 309 8 can can AUX dti-1357 309 9 bring bring VERB dti-1357 309 10 a a DET dti-1357 309 11 substantial substantial ADJ dti-1357 309 12 advancement advancement NOUN dti-1357 309 13 to to PART dti-1357 309 14 test test VERB dti-1357 309 15 the the DET dti-1357 309 16 effectiveness effectiveness NOUN dti-1357 309 17 of of ADP dti-1357 309 18 the the DET dti-1357 309 19 currently currently ADV dti-1357 309 20 available available ADJ dti-1357 309 21 drugs drug NOUN dti-1357 309 22 . . PUNCT dti-1357 310 1 further far ADV dti-1357 310 2 wet wet ADJ dti-1357 310 3 lab lab NOUN dti-1357 310 4 experiments experiment NOUN dti-1357 310 5 are be AUX dti-1357 310 6 essential essential ADJ dti-1357 310 7 to to PART dti-1357 310 8 validate validate VERB dti-1357 310 9 the the DET dti-1357 310 10 obtained obtain VERB dti-1357 310 11 findings finding NOUN dti-1357 310 12 . . PUNCT dti-1357 311 1 author author NOUN dti-1357 311 2 contributions contribution NOUN dti-1357 311 3 conceived conceive VERB dti-1357 311 4 and and CCONJ dti-1357 311 5 designed design VERB dti-1357 311 6 the the DET dti-1357 311 7 experiments experiment NOUN dti-1357 311 8 : : PUNCT dti-1357 311 9 msh msh PROPN dti-1357 311 10 and and CCONJ dti-1357 311 11 mmp mmp PROPN dti-1357 311 12 . . PROPN dti-1357 311 13 analyzed analyze VERB dti-1357 311 14 the the DET dti-1357 311 15 data datum NOUN dti-1357 311 16 : : PUNCT dti-1357 311 17 mmp mmp PROPN dti-1357 311 18 and and CCONJ dti-1357 311 19 mr mr PROPN dti-1357 311 20 . . PROPN dti-1357 311 21 wrote write VERB dti-1357 311 22 the the DET dti-1357 311 23 first first ADJ dti-1357 311 24 draft draft NOUN dti-1357 311 25 of of ADP dti-1357 311 26 the the DET dti-1357 311 27 manuscript manuscript NOUN dti-1357 311 28 : : PUNCT dti-1357 311 29 mmp mmp PROPN dti-1357 311 30 . . PROPN dti-1357 311 31 contributed contribute VERB dti-1357 311 32 to to ADP dti-1357 311 33 the the DET dti-1357 311 34 writing writing NOUN dti-1357 311 35 of of ADP dti-1357 311 36 the the DET dti-1357 311 37 manuscript manuscript NOUN dti-1357 311 38 : : PUNCT dti-1357 311 39 mr mr PROPN dti-1357 311 40 . . PROPN dti-1357 311 41 agree agree VERB dti-1357 311 42 with with ADP dti-1357 311 43 manuscript manuscript NOUN dti-1357 311 44 results result NOUN dti-1357 311 45 and and CCONJ dti-1357 311 46 conclusions conclusion NOUN dti-1357 311 47 : : PUNCT dti-1357 311 48 mmp mmp PROPN dti-1357 311 49 , , PUNCT dti-1357 311 50 mr mr PROPN dti-1357 311 51 , , PUNCT dti-1357 311 52 and and CCONJ dti-1357 311 53 msh msh PROPN dti-1357 311 54 . . PUNCT dti-1357 312 1 jointly jointly ADV dti-1357 312 2 developed develop VERB dti-1357 312 3 the the DET dti-1357 312 4 structure structure NOUN dti-1357 312 5 and and CCONJ dti-1357 312 6 arguments argument NOUN dti-1357 312 7 for for ADP dti-1357 312 8 the the DET dti-1357 312 9 paper paper NOUN dti-1357 312 10 : : PUNCT dti-1357 312 11 mmp mmp PROPN dti-1357 312 12 and and CCONJ dti-1357 312 13 mr mr PROPN dti-1357 312 14 . . PROPN dti-1357 312 15 made make VERB dti-1357 312 16 critical critical ADJ dti-1357 312 17 revisions revision NOUN dti-1357 312 18 and and CCONJ dti-1357 312 19 approved approve VERB dti-1357 312 20 final final ADJ dti-1357 312 21 version version NOUN dti-1357 312 22 : : PUNCT dti-1357 312 23 msh msh PROPN dti-1357 312 24 . . PUNCT dti-1357 313 1 all all DET dti-1357 313 2 authors author NOUN dti-1357 313 3 reviewed review VERB dti-1357 313 4 and and CCONJ dti-1357 313 5 approved approve VERB dti-1357 313 6 of of ADP dti-1357 313 7 the the DET dti-1357 313 8 final final ADJ dti-1357 313 9 manuscript manuscript NOUN dti-1357 313 10 . . PUNCT dti-1357 314 1 references reference NOUN dti-1357 314 2 1 1 NUM dti-1357 314 3 . . PUNCT dti-1357 315 1 razin razin PROPN dti-1357 315 2 s s PROPN dti-1357 315 3 , , PUNCT dti-1357 315 4 yogev yogev PROPN dti-1357 315 5 d d PROPN dti-1357 315 6 , , PUNCT dti-1357 315 7 naot naot PROPN dti-1357 315 8 y. y. PROPN dti-1357 315 9 molecular molecular ADJ dti-1357 315 10 biology biology NOUN dti-1357 315 11 and and CCONJ dti-1357 315 12 pathogenicity pathogenicity NOUN dti-1357 315 13 of of ADP dti-1357 315 14 mycoplasmas mycoplasmas PROPN dti-1357 315 15 . . PUNCT dti-1357 316 1 microbiol microbiol PROPN dti-1357 316 2 mol mol ADP dti-1357 316 3 biol biol PROPN dti-1357 316 4 rev rev PROPN dti-1357 316 5 . . PROPN dti-1357 317 1 1998;62(4):1094–1156 1998;62(4):1094–1156 PROPN dti-1357 317 2 . . PUNCT dti-1357 318 1 2 2 X dti-1357 318 2 . . X dti-1357 318 3 waites waites PROPN dti-1357 318 4 k k PROPN dti-1357 318 5 , , PUNCT dti-1357 318 6 talkington talkington PROPN dti-1357 318 7 d. d. PROPN dti-1357 318 8 new new ADJ dti-1357 318 9 developments development NOUN dti-1357 318 10 in in ADP dti-1357 318 11 human human ADJ dti-1357 318 12 diseases disease NOUN dti-1357 318 13 due due ADJ dti-1357 318 14 to to ADP dti-1357 318 15 mycoplasmas mycoplasmas PROPN dti-1357 318 16 . . PUNCT dti-1357 319 1 in in ADP dti-1357 319 2 : : PUNCT dti-1357 319 3 blanchard blanchard PROPN dti-1357 319 4 a a PRON dti-1357 319 5 , , PUNCT dti-1357 319 6 browning brown VERB dti-1357 319 7 g g NOUN dti-1357 319 8 , , PUNCT dti-1357 319 9 eds ed NOUN dti-1357 319 10 . . PUNCT dti-1357 320 1 mycoplasmas mycoplasmas PROPN dti-1357 320 2 molecular molecular ADJ dti-1357 320 3 biology biology NOUN dti-1357 320 4 pathogenicity pathogenicity NOUN dti-1357 320 5 and and CCONJ dti-1357 320 6 strategies strategy NOUN dti-1357 320 7 for for ADP dti-1357 320 8 control control NOUN dti-1357 320 9 . . PUNCT dti-1357 321 1 norfolk norfolk PROPN dti-1357 321 2 : : PUNCT dti-1357 321 3 horizon horizon PROPN dti-1357 321 4 bioscience bioscience NOUN dti-1357 321 5 ; ; PUNCT dti-1357 321 6 2005:289–354 2005:289–354 NOUN dti-1357 321 7 . . NOUN dti-1357 321 8 3 3 NUM dti-1357 321 9 . . X dti-1357 321 10 xiao xiao PROPN dti-1357 321 11 jc jc PROPN dti-1357 321 12 , , PUNCT dti-1357 321 13 xie xie PROPN dti-1357 321 14 lf lf PROPN dti-1357 321 15 , , PUNCT dti-1357 321 16 fang fang PROPN dti-1357 321 17 sl sl PROPN dti-1357 321 18 , , PUNCT dti-1357 321 19 et et PROPN dti-1357 321 20 al al PROPN dti-1357 321 21 . . PUNCT dti-1357 321 22 symbiosis symbiosis NOUN dti-1357 321 23 of of ADP dti-1357 321 24 mycoplasma mycoplasma NOUN dti-1357 321 25 hominis homini NOUN dti-1357 321 26 in in ADP dti-1357 321 27 trichomonas trichomona NOUN dti-1357 321 28 vaginalis vaginali NOUN dti-1357 321 29 may may AUX dti-1357 321 30 link link VERB dti-1357 321 31 metronidazole metronidazole NOUN dti-1357 321 32 resistance resistance NOUN dti-1357 321 33 in in ADP dti-1357 321 34 vitro vitro X dti-1357 321 35 . . PUNCT dti-1357 322 1 parasitol parasitol NOUN dti-1357 322 2 res re NOUN dti-1357 322 3 . . PUNCT dti-1357 323 1 2006;100(1 2006;100(1 NUM dti-1357 323 2 ): ): PUNCT dti-1357 323 3 123–130 123–130 NUM dti-1357 323 4 . . PUNCT dti-1357 323 5 4 4 NUM dti-1357 323 6 . . X dti-1357 323 7 mammen mammen PROPN dti-1357 323 8 - - PUNCT dti-1357 323 9 tobin tobin PROPN dti-1357 323 10 a a NOUN dti-1357 323 11 , , PUNCT dti-1357 323 12 wilson wilson PROPN dti-1357 323 13 jd jd PROPN dti-1357 323 14 . . PUNCT dti-1357 324 1 management management NOUN dti-1357 324 2 of of ADP dti-1357 324 3 metronidazole metronidazole NOUN dti-1357 324 4 - - PUNCT dti-1357 324 5 resistant resistant ADJ dti-1357 324 6 trichomonas trichomona NOUN dti-1357 324 7 vaginalis vaginalis NOUN dti-1357 324 8 — — PUNCT dti-1357 324 9 a a DET dti-1357 324 10 new new ADJ dti-1357 324 11 approach approach NOUN dti-1357 324 12 . . PUNCT dti-1357 325 1 int int NOUN dti-1357 325 2 j j PROPN dti-1357 325 3 std std X dti-1357 325 4 aids aids PROPN dti-1357 325 5 . . PUNCT dti-1357 326 1 2005;16(7):488–490 2005;16(7):488–490 NUM dti-1357 326 2 . . NOUN dti-1357 326 3 5 5 NUM dti-1357 326 4 . . PUNCT dti-1357 327 1 kataoka kataoka PROPN dti-1357 327 2 s s PROPN dti-1357 327 3 , , PUNCT dti-1357 327 4 yamada yamada PROPN dti-1357 327 5 t t PROPN dti-1357 327 6 , , PUNCT dti-1357 327 7 chou chou PROPN dti-1357 327 8 k k PROPN dti-1357 327 9 , , PUNCT dti-1357 327 10 et et PROPN dti-1357 327 11 al al PROPN dti-1357 327 12 . . PROPN dti-1357 327 13 association association PROPN dti-1357 327 14 between between ADP dti-1357 327 15 preterm preterm ADJ dti-1357 327 16 birth birth NOUN dti-1357 327 17 and and CCONJ dti-1357 327 18 vaginal vaginal ADJ dti-1357 327 19 colonization colonization NOUN dti-1357 327 20 by by ADP dti-1357 327 21 mycoplasmas mycoplasmas PROPN dti-1357 327 22 in in ADP dti-1357 327 23 early early ADJ dti-1357 327 24 pregnancy pregnancy NOUN dti-1357 327 25 . . PUNCT dti-1357 328 1 j j PROPN dti-1357 328 2 clin clin PROPN dti-1357 328 3 microbiol microbiol PROPN dti-1357 328 4 . . PUNCT dti-1357 329 1 2006;44(1 2006;44(1 NUM dti-1357 329 2 ): ): PUNCT dti-1357 329 3 51–55 51–55 NUM dti-1357 329 4 . . NOUN dti-1357 329 5 6 6 NUM dti-1357 329 6 . . PUNCT dti-1357 330 1 stellrecht stellrecht PROPN dti-1357 330 2 ka ka PROPN dti-1357 330 3 , , PUNCT dti-1357 330 4 woron woron PROPN dti-1357 330 5 am be AUX dti-1357 330 6 , , PUNCT dti-1357 330 7 mishrik mishrik PROPN dti-1357 330 8 ng ng PROPN dti-1357 330 9 , , PUNCT dti-1357 330 10 venezia venezia PROPN dti-1357 330 11 ra ra PROPN dti-1357 330 12 . . PROPN dti-1357 330 13 comparison comparison NOUN dti-1357 330 14 of of ADP dti-1357 330 15 multiplex multiplex PROPN dti-1357 330 16 pcr pcr PROPN dti-1357 330 17 assay assay VERB dti-1357 330 18 with with ADP dti-1357 330 19 culture culture NOUN dti-1357 330 20 for for ADP dti-1357 330 21 detection detection NOUN dti-1357 330 22 of of ADP dti-1357 330 23 genital genital ADJ dti-1357 330 24 mycoplasmas mycoplasma NOUN dti-1357 330 25 . . PUNCT dti-1357 331 1 j j PROPN dti-1357 331 2 clin clin PROPN dti-1357 331 3 microbiol microbiol PROPN dti-1357 331 4 . . PUNCT dti-1357 332 1 2004 2004 NUM dti-1357 332 2 ; ; PUNCT dti-1357 333 1 42(4):1528–1533 42(4):1528–1533 NUM dti-1357 333 2 . . NOUN dti-1357 333 3 7 7 X dti-1357 333 4 . . NUM dti-1357 333 5 ladefoged ladefoge VERB dti-1357 333 6 sa sa PROPN dti-1357 333 7 . . PUNCT dti-1357 334 1 molecular molecular ADJ dti-1357 334 2 dissection dissection NOUN dti-1357 334 3 of of ADP dti-1357 334 4 mycoplasma mycoplasma NOUN dti-1357 334 5 hominis hominis NOUN dti-1357 334 6 . . PUNCT dti-1357 335 1 apmis apmis PROPN dti-1357 335 2 suppl suppl PROPN dti-1357 335 3 . . PUNCT dti-1357 335 4 2000 2000 NUM dti-1357 335 5 ; ; PUNCT dti-1357 336 1 97:1–45 97:1–45 NUM dti-1357 336 2 . . PUNCT dti-1357 337 1 8 8 NUM dti-1357 337 2 . . X dti-1357 338 1 mcnaughton mcnaughton PROPN dti-1357 338 2 rd rd PROPN dti-1357 338 3 , , PUNCT dti-1357 338 4 robertson robertson PROPN dti-1357 338 5 ja ja PROPN dti-1357 338 6 , , PUNCT dti-1357 338 7 ratzlaff ratzlaff VERB dti-1357 338 8 vj vj PROPN dti-1357 338 9 , , PUNCT dti-1357 338 10 molberg molberg PROPN dti-1357 338 11 cr cr PROPN dti-1357 338 12 . . PROPN dti-1357 338 13 mycoplasma mycoplasma PROPN dti-1357 338 14 hominis hominis ADJ dti-1357 338 15 infection infection NOUN dti-1357 338 16 of of ADP dti-1357 338 17 the the DET dti-1357 338 18 central central ADJ dti-1357 338 19 nervous nervous ADJ dti-1357 338 20 system system NOUN dti-1357 338 21 in in ADP dti-1357 338 22 a a DET dti-1357 338 23 neonate neonate NOUN dti-1357 338 24 . . PUNCT dti-1357 339 1 can can AUX dti-1357 339 2 med med VERB dti-1357 339 3 assoc assoc NOUN dti-1357 339 4 . . PUNCT dti-1357 340 1 1983;129(4):353–354 1983;129(4):353–354 X dti-1357 340 2 . . NOUN dti-1357 340 3 9 9 NUM dti-1357 340 4 . . X dti-1357 340 5 barykova barykova PROPN dti-1357 340 6 ya ya PROPN dti-1357 340 7 , , PUNCT dti-1357 340 8 logunov logunov PROPN dti-1357 340 9 dy dy PROPN dti-1357 340 10 , , PUNCT dti-1357 340 11 shmarov shmarov NOUN dti-1357 340 12 mm mm PROPN dti-1357 340 13 , , PUNCT dti-1357 340 14 et et PROPN dti-1357 340 15 al al PROPN dti-1357 340 16 . . PROPN dti-1357 340 17 association association PROPN dti-1357 340 18 of of ADP dti-1357 340 19 mycoplasma mycoplasma PROPN dti-1357 340 20 hominis hominis ADJ dti-1357 340 21 infection infection NOUN dti-1357 340 22 with with ADP dti-1357 340 23 prostate prostate NOUN dti-1357 340 24 cancer cancer NOUN dti-1357 340 25 . . PUNCT dti-1357 341 1 oncotarget oncotarget NOUN dti-1357 341 2 . . PUNCT dti-1357 342 1 2011;2(4):289–297 2011;2(4):289–297 NUM dti-1357 342 2 . . NOUN dti-1357 342 3 10 10 NUM dti-1357 342 4 . . PUNCT dti-1357 343 1 pereyre pereyre PROPN dti-1357 343 2 s s PROPN dti-1357 343 3 , , PUNCT dti-1357 343 4 gonzalez gonzalez PROPN dti-1357 343 5 p p X dti-1357 343 6 , , PUNCT dti-1357 343 7 de de PROPN dti-1357 343 8 barbeyrac barbeyrac PROPN dti-1357 343 9 b b PROPN dti-1357 343 10 , , PUNCT dti-1357 343 11 et et PROPN dti-1357 343 12 al al PROPN dti-1357 343 13 . . PUNCT dti-1357 343 14 mutations mutation NOUN dti-1357 343 15 in in ADP dti-1357 343 16 23s 23s PROPN dti-1357 343 17 rrna rrna PROPN dti-1357 343 18 account account VERB dti-1357 343 19 for for ADP dti-1357 343 20 intrinsic intrinsic ADJ dti-1357 343 21 resistance resistance NOUN dti-1357 343 22 to to ADP dti-1357 343 23 macrolides macrolide NOUN dti-1357 343 24 in in ADP dti-1357 343 25 mycoplasma mycoplasma NOUN dti-1357 343 26 hominis hominis PROPN dti-1357 343 27 and and CCONJ dti-1357 343 28 mycoplasma mycoplasma VERB dti-1357 343 29 fermentans fermentan NOUN dti-1357 343 30 and and CCONJ dti-1357 343 31 for for ADP dti-1357 343 32 acquired acquire VERB dti-1357 343 33 resistance resistance NOUN dti-1357 343 34 to to ADP dti-1357 343 35 macrolides macrolide NOUN dti-1357 343 36 in in ADP dti-1357 343 37 m. m. NOUN dti-1357 343 38 hominis hominis PROPN dti-1357 343 39 . . PUNCT dti-1357 344 1 antimicrob antimicrob PROPN dti-1357 344 2 agents agents PROPN dti-1357 344 3 chemother chemother PROPN dti-1357 344 4 . . PUNCT dti-1357 345 1 2002;46(10):3142–3150 2002;46(10):3142–3150 NUM dti-1357 345 2 . . PUNCT dti-1357 346 1 11 11 NUM dti-1357 346 2 . . PUNCT dti-1357 347 1 mihai mihai PROPN dti-1357 347 2 m m PROPN dti-1357 347 3 , , PUNCT dti-1357 347 4 valentin valentin PROPN dti-1357 347 5 n n CCONJ dti-1357 347 6 , , PUNCT dti-1357 347 7 bogdan bogdan PROPN dti-1357 347 8 d d PROPN dti-1357 347 9 , , PUNCT dti-1357 347 10 carmen carman NOUN dti-1357 347 11 cm cm PROPN dti-1357 347 12 , , PUNCT dti-1357 347 13 coralia coralia PROPN dti-1357 347 14 b b PROPN dti-1357 347 15 , , PUNCT dti-1357 347 16 demetra demetra PROPN dti-1357 347 17 s. s. PROPN dti-1357 347 18 antibiotic antibiotic ADJ dti-1357 347 19 susceptibility susceptibility NOUN dti-1357 347 20 profiles profile NOUN dti-1357 347 21 of of ADP dti-1357 347 22 mycoplasma mycoplasma NOUN dti-1357 347 23 hominis hominis PROPN dti-1357 347 24 and and CCONJ dti-1357 347 25 ureaplasma ureaplasma NOUN dti-1357 347 26 urealyticum urealyticum NOUN dti-1357 347 27 isolated isolate VERB dti-1357 347 28 during during ADP dti-1357 347 29 a a DET dti-1357 347 30 population population NOUN dti-1357 347 31 - - PUNCT dti-1357 347 32 based base VERB dti-1357 347 33 study study NOUN dti-1357 347 34 concerning concern VERB dti-1357 347 35 women woman NOUN dti-1357 347 36 infertility infertility NOUN dti-1357 347 37 in in ADP dti-1357 347 38 northeast northeast PROPN dti-1357 347 39 romania romania PROPN dti-1357 347 40 . . PUNCT dti-1357 348 1 braz braz PROPN dti-1357 348 2 j j PROPN dti-1357 348 3 microbiol microbiol PROPN dti-1357 348 4 . . PUNCT dti-1357 349 1 2011;42(1):256–260 2011;42(1):256–260 NUM dti-1357 349 2 . . NOUN dti-1357 349 3 12 12 NUM dti-1357 349 4 . . PUNCT dti-1357 350 1 pereyre pereyre PROPN dti-1357 350 2 s s PROPN dti-1357 350 3 , , PUNCT dti-1357 350 4 sirand sirand NOUN dti-1357 350 5 - - PUNCT dti-1357 350 6 pugnet pugnet NOUN dti-1357 350 7 p p NOUN dti-1357 350 8 , , PUNCT dti-1357 350 9 beven beven PROPN dti-1357 350 10 l l NOUN dti-1357 350 11 , , PUNCT dti-1357 350 12 et et PROPN dti-1357 350 13 al al PROPN dti-1357 350 14 . . PUNCT dti-1357 350 15 life life NOUN dti-1357 350 16 on on ADP dti-1357 350 17 arginine arginine NOUN dti-1357 350 18 for for ADP dti-1357 350 19 mycoplasma mycoplasma NOUN dti-1357 350 20 hominis hominis NOUN dti-1357 350 21 : : PUNCT dti-1357 350 22 clues clue NOUN dti-1357 350 23 from from ADP dti-1357 350 24 its its PRON dti-1357 350 25 minimal minimal ADJ dti-1357 350 26 genome genome NOUN dti-1357 350 27 and and CCONJ dti-1357 350 28 comparison comparison NOUN dti-1357 350 29 with with ADP dti-1357 350 30 other other ADJ dti-1357 350 31 human human ADJ dti-1357 350 32 urogenital urogenital ADJ dti-1357 350 33 mycoplasmas mycoplasma NOUN dti-1357 350 34 . . PUNCT dti-1357 351 1 plos plos PROPN dti-1357 351 2 genet genet PROPN dti-1357 351 3 . . PUNCT dti-1357 352 1 2009;5(10):e1000677 2009;5(10):e1000677 PROPN dti-1357 352 2 . . PROPN dti-1357 353 1 13 13 NUM dti-1357 353 2 . . X dti-1357 353 3 sakharkar sakharkar PROPN dti-1357 353 4 kr kr PROPN dti-1357 353 5 , , PUNCT dti-1357 353 6 sakharkar sakharkar PROPN dti-1357 353 7 mk mk PROPN dti-1357 353 8 , , PUNCT dti-1357 353 9 chow chow PROPN dti-1357 353 10 vt vt PROPN dti-1357 353 11 . . PUNCT dti-1357 354 1 a a DET dti-1357 354 2 novel novel ADJ dti-1357 354 3 genomics genomics NOUN dti-1357 354 4 approach approach NOUN dti-1357 354 5 for for ADP dti-1357 354 6 the the DET dti-1357 354 7 identification identification NOUN dti-1357 354 8 of of ADP dti-1357 354 9 drug drug NOUN dti-1357 354 10 targets target NOUN dti-1357 354 11 in in ADP dti-1357 354 12 pathogens pathogen NOUN dti-1357 354 13 , , PUNCT dti-1357 354 14 with with ADP dti-1357 354 15 special special ADJ dti-1357 354 16 reference reference NOUN dti-1357 354 17 to to ADP dti-1357 354 18 pseudomonas pseudomona NOUN dti-1357 354 19 aeruginosa aeruginosa NOUN dti-1357 354 20 . . PUNCT dti-1357 355 1 in in ADP dti-1357 355 2 silico silico NOUN dti-1357 355 3 biol biol NOUN dti-1357 355 4 . . PUNCT dti-1357 356 1 2004;4(3):355–360 2004;4(3):355–360 X dti-1357 356 2 . . NOUN dti-1357 356 3 14 14 NUM dti-1357 356 4 . . PUNCT dti-1357 357 1 perumal perumal NOUN dti-1357 357 2 d d PROPN dti-1357 357 3 , , PUNCT dti-1357 357 4 lim lim PROPN dti-1357 357 5 cs cs PROPN dti-1357 357 6 , , PUNCT dti-1357 357 7 sakharkar sakharkar PROPN dti-1357 357 8 kr kr PROPN dti-1357 357 9 , , PUNCT dti-1357 357 10 sakharkar sakharkar PROPN dti-1357 357 11 mk mk PROPN dti-1357 357 12 . . PUNCT dti-1357 357 13 differential differential ADJ dti-1357 357 14 genome genome NOUN dti-1357 357 15 analyses analysis NOUN dti-1357 357 16 of of ADP dti-1357 357 17 metabolic metabolic NOUN dti-1357 357 18 enzymes enzyme NOUN dti-1357 357 19 in in ADP dti-1357 357 20 pseudomonas pseudomona NOUN dti-1357 357 21 aeruginosa aeruginosa NOUN dti-1357 357 22 for for ADP dti-1357 357 23 drug drug NOUN dti-1357 357 24 target target NOUN dti-1357 357 25 identification identification NOUN dti-1357 357 26 . . PUNCT dti-1357 358 1 in in ADP dti-1357 358 2 silico silico NOUN dti-1357 358 3 biol biol NOUN dti-1357 358 4 . . PUNCT dti-1357 359 1 2007;7(4–5):453–465 2007;7(4–5):453–465 NUM dti-1357 359 2 . . PUNCT dti-1357 359 3 15 15 NUM dti-1357 359 4 . . PUNCT dti-1357 360 1 amineni amineni PROPN dti-1357 360 2 u u PROPN dti-1357 360 3 , , PUNCT dti-1357 360 4 pradhan pradhan PROPN dti-1357 360 5 d d PROPN dti-1357 360 6 , , PUNCT dti-1357 360 7 marisetty marisetty PROPN dti-1357 360 8 h. h. PROPN dti-1357 360 9 in in ADP dti-1357 360 10 silico silico NOUN dti-1357 360 11 identification identification NOUN dti-1357 360 12 of of ADP dti-1357 360 13 common common ADJ dti-1357 360 14 putative putative ADJ dti-1357 360 15 drug drug NOUN dti-1357 360 16 targets target NOUN dti-1357 360 17 in in ADP dti-1357 360 18 leptospira leptospira NOUN dti-1357 360 19 interrogans interrogan NOUN dti-1357 360 20 . . PUNCT dti-1357 361 1 j j PROPN dti-1357 361 2 chem chem PROPN dti-1357 361 3 biol biol PROPN dti-1357 361 4 . . PUNCT dti-1357 362 1 2010;3(4):165–173 2010;3(4):165–173 NUM dti-1357 362 2 . . X dti-1357 362 3 16 16 NUM dti-1357 362 4 . . PUNCT dti-1357 362 5 abadio abadio PROPN dti-1357 362 6 ak ak PROPN dti-1357 362 7 , , PUNCT dti-1357 362 8 kioshima kioshima PROPN dti-1357 362 9 es es PROPN dti-1357 362 10 , , PUNCT dti-1357 362 11 teixeira teixeira PROPN dti-1357 362 12 mm mm PROPN dti-1357 362 13 , , PUNCT dti-1357 362 14 martins martin NOUN dti-1357 362 15 nf nf PROPN dti-1357 362 16 , , PUNCT dti-1357 362 17 maigret maigret PROPN dti-1357 362 18 b b PROPN dti-1357 362 19 , , PUNCT dti-1357 362 20 felipe felipe PROPN dti-1357 362 21 ms ms PROPN dti-1357 362 22 . . PROPN dti-1357 362 23 comparative comparative ADJ dti-1357 362 24 genomics genomic NOUN dti-1357 362 25 allowed allow VERB dti-1357 362 26 the the DET dti-1357 362 27 identification identification NOUN dti-1357 362 28 of of ADP dti-1357 362 29 drug drug NOUN dti-1357 362 30 targets target NOUN dti-1357 362 31 against against ADP dti-1357 362 32 human human ADJ dti-1357 362 33 fungal fungal ADJ dti-1357 362 34 pathogens pathogen NOUN dti-1357 362 35 . . PUNCT dti-1357 363 1 bmc bmc ADJ dti-1357 363 2 genomics genomic NOUN dti-1357 363 3 . . PUNCT dti-1357 364 1 2011;12:75 2011;12:75 NUM dti-1357 364 2 . . PUNCT dti-1357 365 1 17 17 NUM dti-1357 365 2 . . PUNCT dti-1357 366 1 galperin galperin VERB dti-1357 366 2 my my PRON dti-1357 366 3 , , PUNCT dti-1357 366 4 koonin koonin ADJ dti-1357 366 5 ev ev PROPN dti-1357 366 6 . . PROPN dti-1357 366 7 searching search VERB dti-1357 366 8 for for ADP dti-1357 366 9 drug drug NOUN dti-1357 366 10 targets target NOUN dti-1357 366 11 in in ADP dti-1357 366 12 microbial microbial ADJ dti-1357 366 13 genomes genome NOUN dti-1357 366 14 . . PUNCT dti-1357 367 1 curr curr PROPN dti-1357 367 2 opin opin PROPN dti-1357 367 3 biotechnol biotechnol NOUN dti-1357 367 4 . . PUNCT dti-1357 368 1 1999;10(6):571–578 1999;10(6):571–578 NUM dti-1357 368 2 . . PROPN dti-1357 368 3 18 18 NUM dti-1357 368 4 . . X dti-1357 368 5 kanehisa kanehisa PROPN dti-1357 368 6 m m PROPN dti-1357 368 7 , , PUNCT dti-1357 368 8 goto goto NOUN dti-1357 368 9 s s PROPN dti-1357 368 10 , , PUNCT dti-1357 368 11 hattori hattori PROPN dti-1357 368 12 m m PROPN dti-1357 368 13 , , PUNCT dti-1357 368 14 et et PROPN dti-1357 368 15 al al PROPN dti-1357 368 16 . . PROPN dti-1357 369 1 from from ADP dti-1357 369 2 genomics genomic NOUN dti-1357 369 3 to to ADP dti-1357 369 4 chemical chemical NOUN dti-1357 369 5 genomics genomic NOUN dti-1357 369 6 : : PUNCT dti-1357 369 7 new new ADJ dti-1357 369 8 developments development NOUN dti-1357 369 9 in in ADP dti-1357 369 10 kegg kegg NOUN dti-1357 369 11 . . PUNCT dti-1357 370 1 nucleic nucleic ADJ dti-1357 370 2 acids acid NOUN dti-1357 370 3 res re NOUN dti-1357 370 4 . . PUNCT dti-1357 371 1 2006;34(database 2006;34(database PROPN dti-1357 371 2 issue):d354 issue):d354 PROPN dti-1357 371 3 – – PUNCT dti-1357 371 4 d357 d357 PROPN dti-1357 371 5 . . PROPN dti-1357 371 6 19 19 NUM dti-1357 371 7 . . PUNCT dti-1357 371 8 kanehisa kanehisa PROPN dti-1357 371 9 m m PROPN dti-1357 371 10 , , PUNCT dti-1357 371 11 goto goto NOUN dti-1357 371 12 s s NOUN dti-1357 371 13 , , PUNCT dti-1357 371 14 furumichi furumichi PROPN dti-1357 371 15 m m PROPN dti-1357 371 16 , , PUNCT dti-1357 371 17 tanabe tanabe PROPN dti-1357 371 18 m m PROPN dti-1357 371 19 , , PUNCT dti-1357 371 20 hirakawa hirakawa PROPN dti-1357 371 21 m. m. PROPN dti-1357 371 22 kegg kegg NOUN dti-1357 371 23 for for ADP dti-1357 371 24 representation representation NOUN dti-1357 371 25 and and CCONJ dti-1357 371 26 analysis analysis NOUN dti-1357 371 27 of of ADP dti-1357 371 28 molecular molecular ADJ dti-1357 371 29 networks network NOUN dti-1357 371 30 involving involve VERB dti-1357 371 31 diseases disease NOUN dti-1357 371 32 and and CCONJ dti-1357 371 33 drugs drug NOUN dti-1357 371 34 . . PUNCT dti-1357 372 1 nucleic nucleic ADJ dti-1357 372 2 acids acid NOUN dti-1357 372 3 res re NOUN dti-1357 372 4 . . PUNCT dti-1357 373 1 2010;38(database 2010;38(database PROPN dti-1357 373 2 issue):d355 issue):d355 PROPN dti-1357 373 3 – – PUNCT dti-1357 373 4 d360 d360 PROPN dti-1357 373 5 . . PROPN dti-1357 373 6 20 20 NUM dti-1357 373 7 . . PUNCT dti-1357 374 1 zhang zhang PROPN dti-1357 374 2 r r PROPN dti-1357 374 3 , , PUNCT dti-1357 374 4 ou ou PROPN dti-1357 374 5 hy hy PROPN dti-1357 374 6 , , PUNCT dti-1357 374 7 zhang zhang PROPN dti-1357 374 8 ct ct PROPN dti-1357 374 9 . . PUNCT dti-1357 375 1 deg deg PROPN dti-1357 375 2 : : PUNCT dti-1357 375 3 a a DET dti-1357 375 4 database database NOUN dti-1357 375 5 of of ADP dti-1357 375 6 essential essential ADJ dti-1357 375 7 genes gene NOUN dti-1357 375 8 . . PUNCT dti-1357 376 1 nucleic nucleic ADJ dti-1357 376 2 acids acid NOUN dti-1357 376 3 res re NOUN dti-1357 376 4 . . PUNCT dti-1357 377 1 2004;32(database 2004;32(database PROPN dti-1357 377 2 issue):d271 issue):d271 NOUN dti-1357 377 3 – – PUNCT dti-1357 377 4 d272 d272 PROPN dti-1357 377 5 . . PROPN dti-1357 378 1 21 21 NUM dti-1357 378 2 . . PUNCT dti-1357 378 3 altschul altschul PROPN dti-1357 378 4 sf sf PROPN dti-1357 378 5 , , PUNCT dti-1357 378 6 madden madden PROPN dti-1357 378 7 tl tl PROPN dti-1357 378 8 , , PUNCT dti-1357 378 9 schäffer schäffer VERB dti-1357 378 10 aa aa PROPN dti-1357 378 11 , , PUNCT dti-1357 378 12 et et PROPN dti-1357 378 13 al al PROPN dti-1357 378 14 . . PROPN dti-1357 378 15 gapped gapped NOUN dti-1357 378 16 blast blast NOUN dti-1357 378 17 and and CCONJ dti-1357 378 18 psi psi NOUN dti-1357 378 19 - - PUNCT dti-1357 378 20 blast blast NOUN dti-1357 378 21 : : PUNCT dti-1357 378 22 a a DET dti-1357 378 23 new new ADJ dti-1357 378 24 generation generation NOUN dti-1357 378 25 of of ADP dti-1357 378 26 protein protein NOUN dti-1357 378 27 database database NOUN dti-1357 378 28 search search NOUN dti-1357 378 29 programs program NOUN dti-1357 378 30 . . PUNCT dti-1357 379 1 nucleic nucleic ADJ dti-1357 379 2 acids acid NOUN dti-1357 379 3 res re NOUN dti-1357 379 4 . . PUNCT dti-1357 380 1 1997;25(17 1997;25(17 NUM dti-1357 380 2 ): ): PUNCT dti-1357 380 3 3389–3402 3389–3402 NUM dti-1357 380 4 . . NOUN dti-1357 380 5 22 22 NUM dti-1357 380 6 . . PUNCT dti-1357 381 1 duffield duffield PROPN dti-1357 381 2 m m PROPN dti-1357 381 3 , , PUNCT dti-1357 381 4 cooper cooper PROPN dti-1357 381 5 i i PROPN dti-1357 381 6 , , PUNCT dti-1357 381 7 mcalister mcalister PROPN dti-1357 381 8 e e PROPN dti-1357 381 9 , , PUNCT dti-1357 381 10 bayliss bayliss PROPN dti-1357 381 11 m m PROPN dti-1357 381 12 , , PUNCT dti-1357 381 13 ford ford PROPN dti-1357 381 14 d d PROPN dti-1357 381 15 , , PUNCT dti-1357 381 16 oyston oyston PROPN dti-1357 381 17 p. p. NOUN dti-1357 381 18 predicting predict VERB dti-1357 381 19 conserved conserve VERB dti-1357 381 20 essential essential ADJ dti-1357 381 21 genes gene NOUN dti-1357 381 22 in in ADP dti-1357 381 23 bacteria bacteria NOUN dti-1357 381 24 : : PUNCT dti-1357 381 25 in in ADP dti-1357 381 26 silico silico NOUN dti-1357 381 27 identification identification NOUN dti-1357 381 28 of of ADP dti-1357 381 29 putative putative ADJ dti-1357 381 30 drug drug NOUN dti-1357 381 31 targets target NOUN dti-1357 381 32 . . PUNCT dti-1357 382 1 mol mol ADP dti-1357 382 2 biosyst biosyst NOUN dti-1357 382 3 . . PUNCT dti-1357 383 1 2010;6(12):2482–2489 2010;6(12):2482–2489 PROPN dti-1357 383 2 . . PUNCT dti-1357 384 1 23 23 NUM dti-1357 384 2 . . PUNCT dti-1357 385 1 berman berman PROPN dti-1357 385 2 h h PROPN dti-1357 385 3 , , PUNCT dti-1357 385 4 henrick henrick PROPN dti-1357 385 5 k k PROPN dti-1357 385 6 , , PUNCT dti-1357 385 7 nakamura nakamura PROPN dti-1357 385 8 h h PROPN dti-1357 385 9 , , PUNCT dti-1357 385 10 markley markley PROPN dti-1357 385 11 jl jl PROPN dti-1357 385 12 . . PUNCT dti-1357 386 1 the the DET dti-1357 386 2 worldwide worldwide ADJ dti-1357 386 3 protein protein NOUN dti-1357 386 4 data datum NOUN dti-1357 386 5 bank bank PROPN dti-1357 386 6 ( ( PUNCT dti-1357 386 7 wwpdb wwpdb ADJ dti-1357 386 8 ): ): PUNCT dti-1357 386 9 ensuring ensure VERB dti-1357 386 10 a a DET dti-1357 386 11 single single ADJ dti-1357 386 12 , , PUNCT dti-1357 386 13 uniform uniform ADJ dti-1357 386 14 archive archive NOUN dti-1357 386 15 of of ADP dti-1357 386 16 pdb pdb PROPN dti-1357 386 17 data data PROPN dti-1357 386 18 . . PUNCT dti-1357 387 1 nucleic nucleic ADJ dti-1357 387 2 acids acid NOUN dti-1357 387 3 res re NOUN dti-1357 387 4 . . PUNCT dti-1357 388 1 2007;35(database 2007;35(database PROPN dti-1357 388 2 issue):d301 issue):d301 PROPN dti-1357 388 3 – – PUNCT dti-1357 388 4 d303 d303 PROPN dti-1357 388 5 . . PROPN dti-1357 388 6 24 24 NUM dti-1357 388 7 . . PUNCT dti-1357 389 1 kouranov kouranov PROPN dti-1357 389 2 a a PRON dti-1357 389 3 , , PUNCT dti-1357 389 4 xie xie PROPN dti-1357 389 5 l l PROPN dti-1357 389 6 , , PUNCT dti-1357 389 7 de de PROPN dti-1357 389 8 lacruz lacruz PROPN dti-1357 389 9 j j PROPN dti-1357 389 10 , , PUNCT dti-1357 389 11 et et PROPN dti-1357 389 12 al al PROPN dti-1357 389 13 . . PUNCT dti-1357 390 1 the the DET dti-1357 390 2 rcsb rcsb PROPN dti-1357 390 3 pdb pdb PROPN dti-1357 390 4 information information NOUN dti-1357 390 5 portal portal PROPN dti-1357 390 6 for for ADP dti-1357 390 7 structural structural ADJ dti-1357 390 8 genomics genomic NOUN dti-1357 390 9 . . PUNCT dti-1357 391 1 nucleic nucleic ADJ dti-1357 391 2 acids acid NOUN dti-1357 391 3 res re NOUN dti-1357 391 4 . . PUNCT dti-1357 392 1 2006;34(database 2006;34(database ADJ dti-1357 392 2 issue):d302 issue):d302 PROPN dti-1357 392 3 – – PUNCT dti-1357 392 4 d305 d305 PROPN dti-1357 392 5 . . PUNCT dti-1357 393 1 25 25 NUM dti-1357 393 2 . . PUNCT dti-1357 393 3 pieper pieper PROPN dti-1357 393 4 u u PROPN dti-1357 393 5 , , PUNCT dti-1357 393 6 webb webb PROPN dti-1357 393 7 bm bm PROPN dti-1357 393 8 , , PUNCT dti-1357 393 9 barkan barkan VERB dti-1357 393 10 dt dt PROPN dti-1357 393 11 , , PUNCT dti-1357 393 12 et et PROPN dti-1357 393 13 al al PROPN dti-1357 393 14 . . PROPN dti-1357 393 15 modbase modbase PROPN dti-1357 393 16 , , PUNCT dti-1357 393 17 a a DET dti-1357 393 18 database database NOUN dti-1357 393 19 of of ADP dti-1357 393 20 annotated annotate VERB dti-1357 393 21 comparative comparative ADJ dti-1357 393 22 protein protein NOUN dti-1357 393 23 structure structure NOUN dti-1357 393 24 models model NOUN dti-1357 393 25 , , PUNCT dti-1357 393 26 and and CCONJ dti-1357 393 27 associated associated ADJ dti-1357 393 28 resources resource NOUN dti-1357 393 29 . . PUNCT dti-1357 394 1 nucleic nucleic ADJ dti-1357 394 2 acids acid NOUN dti-1357 394 3 res re NOUN dti-1357 394 4 . . PROPN dti-1357 394 5 2011;39(database 2011;39(database PROPN dti-1357 394 6 issue):d465 issue):d465 PROPN dti-1357 394 7 – – PUNCT dti-1357 394 8 d474 d474 PROPN dti-1357 394 9 . . PROPN dti-1357 395 1 26 26 NUM dti-1357 395 2 . . PUNCT dti-1357 395 3 pieper pieper PROPN dti-1357 395 4 u u PROPN dti-1357 395 5 , , PUNCT dti-1357 395 6 webb webb PROPN dti-1357 395 7 bm bm PROPN dti-1357 395 8 , , PUNCT dti-1357 395 9 dong dong PROPN dti-1357 395 10 gq gq PROPN dti-1357 395 11 , , PUNCT dti-1357 395 12 et et PROPN dti-1357 395 13 al al PROPN dti-1357 395 14 . . PROPN dti-1357 395 15 modbase modbase PROPN dti-1357 395 16 , , PUNCT dti-1357 395 17 a a DET dti-1357 395 18 database database NOUN dti-1357 395 19 of of ADP dti-1357 395 20 annotated annotate VERB dti-1357 395 21 comparative comparative ADJ dti-1357 395 22 protein protein NOUN dti-1357 395 23 structure structure NOUN dti-1357 395 24 models model NOUN dti-1357 395 25 and and CCONJ dti-1357 395 26 associated associated ADJ dti-1357 395 27 resources resource NOUN dti-1357 395 28 . . PUNCT dti-1357 396 1 nucleic nucleic ADJ dti-1357 396 2 acids acid NOUN dti-1357 396 3 res re NOUN dti-1357 396 4 . . PUNCT dti-1357 396 5 2014;42(database 2014;42(database ADJ dti-1357 396 6 issue):d336 issue):d336 NOUN dti-1357 396 7 – – PUNCT dti-1357 396 8 d346 d346 ADJ dti-1357 396 9 . . PUNCT dti-1357 397 1 27 27 NUM dti-1357 397 2 . . X dti-1357 397 3 agüero agüero NOUN dti-1357 397 4 f f PROPN dti-1357 397 5 , , PUNCT dti-1357 397 6 al al PROPN dti-1357 397 7 - - PUNCT dti-1357 397 8 lazikani lazikani PROPN dti-1357 397 9 b b PROPN dti-1357 397 10 , , PUNCT dti-1357 397 11 aslett aslett PROPN dti-1357 397 12 m m PROPN dti-1357 397 13 , , PUNCT dti-1357 397 14 et et PROPN dti-1357 397 15 al al PROPN dti-1357 397 16 . . PUNCT dti-1357 397 17 genomic genomic ADJ dti-1357 397 18 - - PUNCT dti-1357 397 19 scale scale NOUN dti-1357 397 20 prioritization prioritization NOUN dti-1357 397 21 of of ADP dti-1357 397 22 drug drug NOUN dti-1357 397 23 targets target NOUN dti-1357 397 24 : : PUNCT dti-1357 397 25 the the DET dti-1357 397 26 tdr tdr PROPN dti-1357 397 27 targets target NOUN dti-1357 397 28 database database NOUN dti-1357 397 29 . . PUNCT dti-1357 398 1 nat nat PROPN dti-1357 398 2 rev rev VERB dti-1357 398 3 . . PUNCT dti-1357 399 1 2008;7(11):900–907 2008;7(11):900–907 NUM dti-1357 399 2 . . PUNCT dti-1357 400 1 28 28 NUM dti-1357 400 2 . . PUNCT dti-1357 401 1 barh barh PROPN dti-1357 401 2 d d PROPN dti-1357 401 3 , , PUNCT dti-1357 401 4 tiwari tiwari PROPN dti-1357 401 5 s s PROPN dti-1357 401 6 , , PUNCT dti-1357 401 7 jain jain PROPN dti-1357 401 8 n n CCONJ dti-1357 401 9 , , PUNCT dti-1357 401 10 et et PROPN dti-1357 401 11 al al PROPN dti-1357 401 12 . . PROPN dti-1357 402 1 in in ADP dti-1357 402 2 silico silico NOUN dti-1357 402 3 subtractive subtractive NOUN dti-1357 402 4 genomics genomic NOUN dti-1357 402 5 for for ADP dti-1357 402 6 target target NOUN dti-1357 402 7 identification identification NOUN dti-1357 402 8 in in ADP dti-1357 402 9 human human ADJ dti-1357 402 10 bacterial bacterial ADJ dti-1357 402 11 pathogens pathogen NOUN dti-1357 402 12 . . PUNCT dti-1357 403 1 drug drug NOUN dti-1357 403 2 dev dev PROPN dti-1357 403 3 res re NOUN dti-1357 403 4 . . PUNCT dti-1357 404 1 2011;72(2):162–177 2011;72(2):162–177 NUM dti-1357 404 2 . . PROPN dti-1357 404 3 29 29 NUM dti-1357 404 4 . . PUNCT dti-1357 404 5 yu yu PROPN dti-1357 404 6 ny ny PROPN dti-1357 404 7 , , PUNCT dti-1357 404 8 wagner wagner PROPN dti-1357 404 9 jr jr PROPN dti-1357 404 10 , , PUNCT dti-1357 404 11 laird laird PROPN dti-1357 404 12 mr mr PROPN dti-1357 404 13 , , PUNCT dti-1357 404 14 et et PROPN dti-1357 404 15 al al PROPN dti-1357 404 16 . . PROPN dti-1357 404 17 psortb psortb PROPN dti-1357 404 18 3.0 3.0 NUM dti-1357 404 19 : : PUNCT dti-1357 404 20 improved improve VERB dti-1357 404 21 protein protein NOUN dti-1357 404 22 subcellular subcellular ADJ dti-1357 404 23 localization localization NOUN dti-1357 404 24 prediction prediction NOUN dti-1357 404 25 with with ADP dti-1357 404 26 refined refined ADJ dti-1357 404 27 localization localization NOUN dti-1357 404 28 subcategories subcategorie NOUN dti-1357 404 29 and and CCONJ dti-1357 404 30 predictive predictive ADJ dti-1357 404 31 capabilities capability NOUN dti-1357 404 32 for for ADP dti-1357 404 33 all all DET dti-1357 404 34 prokaryotes prokaryote NOUN dti-1357 404 35 . . PUNCT dti-1357 405 1 bioinformatics bioinformatic NOUN dti-1357 405 2 ( ( PUNCT dti-1357 405 3 oxford oxford PROPN dti-1357 405 4 , , PUNCT dti-1357 405 5 england england PROPN dti-1357 405 6 ) ) PUNCT dti-1357 405 7 . . PUNCT dti-1357 406 1 2010;26(13 2010;26(13 NUM dti-1357 406 2 ): ): PUNCT dti-1357 406 3 1608–1615 1608–1615 NUM dti-1357 406 4 . . PUNCT dti-1357 407 1 30 30 NUM dti-1357 407 2 . . PUNCT dti-1357 408 1 yu yu PROPN dti-1357 408 2 c c PROPN dti-1357 408 3 - - SYM dti-1357 408 4 s s PROPN dti-1357 408 5 , , PUNCT dti-1357 408 6 lin lin PROPN dti-1357 408 7 c c PROPN dti-1357 408 8 - - PUNCT dti-1357 408 9 j j PROPN dti-1357 408 10 , , PUNCT dti-1357 408 11 hwang hwang PROPN dti-1357 408 12 j j PROPN dti-1357 408 13 - - PUNCT dti-1357 408 14 k. k. PROPN dti-1357 408 15 predicting predict VERB dti-1357 408 16 subcellular subcellular ADJ dti-1357 408 17 localization localization NOUN dti-1357 408 18 of of ADP dti-1357 408 19 proteins protein NOUN dti-1357 408 20 for for ADP dti-1357 408 21 gram gram NOUN dti-1357 408 22 - - PUNCT dti-1357 408 23 negative negative ADJ dti-1357 408 24 bacteria bacteria NOUN dti-1357 408 25 by by ADP dti-1357 408 26 support support NOUN dti-1357 408 27 vector vector NOUN dti-1357 408 28 machines machine NOUN dti-1357 408 29 based base VERB dti-1357 408 30 on on ADP dti-1357 408 31 n n CCONJ dti-1357 408 32 - - PUNCT dti-1357 408 33 peptide peptide NOUN dti-1357 408 34 compositions composition NOUN dti-1357 408 35 . . PUNCT dti-1357 409 1 protein protein NOUN dti-1357 409 2 sci sci PROPN dti-1357 409 3 . . PUNCT dti-1357 409 4 2004;13(5):1402–1406 2004;13(5):1402–1406 PROPN dti-1357 409 5 . . PUNCT dti-1357 410 1 31 31 NUM dti-1357 410 2 . . X dti-1357 410 3 yu yu PROPN dti-1357 410 4 c c PROPN dti-1357 410 5 - - PUNCT dti-1357 410 6 s s PROPN dti-1357 410 7 , , PUNCT dti-1357 410 8 chen chen PROPN dti-1357 410 9 y y PROPN dti-1357 410 10 - - PUNCT dti-1357 410 11 c c PROPN dti-1357 410 12 , , PUNCT dti-1357 410 13 lu lu PROPN dti-1357 410 14 c c NOUN dti-1357 410 15 - - PUNCT dti-1357 410 16 h h PROPN dti-1357 410 17 , , PUNCT dti-1357 410 18 hwang hwang PROPN dti-1357 410 19 j j PROPN dti-1357 410 20 - - PUNCT dti-1357 410 21 k. k. PROPN dti-1357 410 22 prediction prediction NOUN dti-1357 410 23 of of ADP dti-1357 410 24 protein protein NOUN dti-1357 410 25 subcellular subcellular ADJ dti-1357 410 26 localization localization NOUN dti-1357 410 27 . . PUNCT dti-1357 411 1 proteins protein NOUN dti-1357 411 2 . . PUNCT dti-1357 412 1 2006;64(3):643–651 2006;64(3):643–651 NUM dti-1357 412 2 . . X dti-1357 412 3 32 32 NUM dti-1357 412 4 . . PUNCT dti-1357 413 1 bernsel bernsel PROPN dti-1357 413 2 a a DET dti-1357 413 3 , , PUNCT dti-1357 413 4 viklund viklund ADJ dti-1357 413 5 h h NOUN dti-1357 413 6 , , PUNCT dti-1357 413 7 hennerdal hennerdal PROPN dti-1357 413 8 a a PROPN dti-1357 413 9 , , PUNCT dti-1357 413 10 elofsson elofsson PROPN dti-1357 413 11 a. a. NOUN dti-1357 413 12 topcons topcon NOUN dti-1357 413 13 : : PUNCT dti-1357 413 14 consensus consensus NOUN dti-1357 413 15 prediction prediction NOUN dti-1357 413 16 of of ADP dti-1357 413 17 membrane membrane NOUN dti-1357 413 18 protein protein NOUN dti-1357 413 19 topology topology NOUN dti-1357 413 20 . . PUNCT dti-1357 414 1 nucleic nucleic ADJ dti-1357 414 2 acids acid NOUN dti-1357 414 3 res re NOUN dti-1357 414 4 . . PUNCT dti-1357 415 1 2009;37(web 2009;37(web NUM dti-1357 415 2 server server NOUN dti-1357 415 3 issue):w465 issue):w465 NOUN dti-1357 415 4 – – PUNCT dti-1357 415 5 w468 w468 PROPN dti-1357 415 6 . . PROPN dti-1357 416 1 33 33 NUM dti-1357 416 2 . . PUNCT dti-1357 417 1 krogh krogh PROPN dti-1357 417 2 a a PRON dti-1357 417 3 , , PUNCT dti-1357 417 4 larsson larsson PROPN dti-1357 417 5 b b PROPN dti-1357 417 6 , , PUNCT dti-1357 417 7 von von PROPN dti-1357 417 8 heijne heijne PROPN dti-1357 417 9 g g PROPN dti-1357 417 10 , , PUNCT dti-1357 417 11 sonnhammer sonnhammer PROPN dti-1357 417 12 el el PROPN dti-1357 417 13 . . PROPN dti-1357 417 14 predicting predict VERB dti-1357 417 15 transmembrane transmembrane ADJ dti-1357 417 16 protein protein NOUN dti-1357 417 17 topology topology NOUN dti-1357 417 18 with with ADP dti-1357 417 19 a a DET dti-1357 417 20 hidden hide VERB dti-1357 417 21 markov markov NOUN dti-1357 417 22 model model NOUN dti-1357 417 23 : : PUNCT dti-1357 417 24 application application NOUN dti-1357 417 25 to to PART dti-1357 417 26 complete complete ADJ dti-1357 417 27 genomes genome NOUN dti-1357 417 28 . . PUNCT dti-1357 418 1 j j PROPN dti-1357 418 2 mol mol ADP dti-1357 418 3 biol biol PROPN dti-1357 418 4 . . PUNCT dti-1357 419 1 2001;305(3):567–580 2001;305(3):567–580 NUM dti-1357 419 2 . . PUNCT dti-1357 420 1 34 34 NUM dti-1357 420 2 . . PUNCT dti-1357 421 1 hunter hunter PROPN dti-1357 421 2 s s PROPN dti-1357 421 3 , , PUNCT dti-1357 421 4 jones jones PROPN dti-1357 421 5 p p PROPN dti-1357 421 6 , , PUNCT dti-1357 421 7 mitchell mitchell PROPN dti-1357 421 8 a a PROPN dti-1357 421 9 , , PUNCT dti-1357 421 10 et et PROPN dti-1357 421 11 al al PROPN dti-1357 421 12 . . PROPN dti-1357 421 13 interpro interpro ADJ dti-1357 421 14 in in ADP dti-1357 421 15 2011 2011 NUM dti-1357 421 16 : : PUNCT dti-1357 422 1 new new ADJ dti-1357 422 2 developments development NOUN dti-1357 422 3 in in ADP dti-1357 422 4 the the DET dti-1357 422 5 family family NOUN dti-1357 422 6 and and CCONJ dti-1357 422 7 domain domain NOUN dti-1357 422 8 prediction prediction NOUN dti-1357 422 9 database database NOUN dti-1357 422 10 . . PUNCT dti-1357 423 1 nucleic nucleic ADJ dti-1357 423 2 acids acid NOUN dti-1357 423 3 res re NOUN dti-1357 423 4 . . PUNCT dti-1357 424 1 2012;40(database 2012;40(database PROPN dti-1357 424 2 issue issue NOUN dti-1357 424 3 ): ): PUNCT dti-1357 424 4 d306 d306 PROPN dti-1357 424 5 – – PUNCT dti-1357 424 6 d312 d312 PROPN dti-1357 424 7 . . PROPN dti-1357 424 8 35 35 NUM dti-1357 424 9 . . PUNCT dti-1357 425 1 raman raman PROPN dti-1357 425 2 k k PROPN dti-1357 425 3 , , PUNCT dti-1357 425 4 yeturu yeturu PROPN dti-1357 425 5 k k PROPN dti-1357 425 6 , , PUNCT dti-1357 425 7 chandra chandra PROPN dti-1357 425 8 n. n. PROPN dti-1357 425 9 targettb targettb PROPN dti-1357 425 10 : : PUNCT dti-1357 425 11 a a DET dti-1357 425 12 target target NOUN dti-1357 425 13 identification identification NOUN dti-1357 425 14 pipeline pipeline NOUN dti-1357 425 15 for for ADP dti-1357 425 16 mycobacterium mycobacterium NOUN dti-1357 425 17 tuberculosis tuberculosis NOUN dti-1357 425 18 through through ADP dti-1357 425 19 an an DET dti-1357 425 20 interactome interactome NOUN dti-1357 425 21 , , PUNCT dti-1357 425 22 reactome reactome NOUN dti-1357 425 23 and and CCONJ dti-1357 425 24 genome genome NOUN dti-1357 425 25 - - PUNCT dti-1357 425 26 scale scale NOUN dti-1357 425 27 structural structural ADJ dti-1357 425 28 analysis analysis NOUN dti-1357 425 29 . . PUNCT dti-1357 426 1 bmc bmc PROPN dti-1357 426 2 syst syst PROPN dti-1357 426 3 biol biol PROPN dti-1357 426 4 . . PUNCT dti-1357 427 1 2008;2:109 2008;2:109 NUM dti-1357 427 2 . . PUNCT dti-1357 428 1 36 36 NUM dti-1357 428 2 . . PUNCT dti-1357 429 1 franceschini franceschini PROPN dti-1357 429 2 a a PRON dti-1357 429 3 , , PUNCT dti-1357 429 4 szklarczyk szklarczyk ADJ dti-1357 429 5 d d NOUN dti-1357 429 6 , , PUNCT dti-1357 429 7 frankild frankild PROPN dti-1357 429 8 s s PROPN dti-1357 429 9 , , PUNCT dti-1357 429 10 et et PROPN dti-1357 429 11 al al PROPN dti-1357 429 12 . . PROPN dti-1357 429 13 string string PROPN dti-1357 430 1 v9.1 v9.1 NOUN dti-1357 430 2 : : PUNCT dti-1357 430 3 protein protein NOUN dti-1357 430 4 - - PUNCT dti-1357 430 5 protein protein NOUN dti-1357 430 6 interaction interaction NOUN dti-1357 430 7 networks network NOUN dti-1357 430 8 , , PUNCT dti-1357 430 9 with with ADP dti-1357 430 10 increased increase VERB dti-1357 430 11 coverage coverage NOUN dti-1357 430 12 and and CCONJ dti-1357 430 13 integration integration NOUN dti-1357 430 14 . . PUNCT dti-1357 431 1 nucleic nucleic ADJ dti-1357 431 2 acids acid NOUN dti-1357 431 3 res re NOUN dti-1357 431 4 . . PUNCT dti-1357 432 1 2013;41(database 2013;41(database PROPN dti-1357 432 2 issue):d808 issue):d808 PROPN dti-1357 432 3 – – PUNCT dti-1357 432 4 d815 d815 PROPN dti-1357 432 5 . . PROPN dti-1357 432 6 37 37 NUM dti-1357 432 7 . . PUNCT dti-1357 433 1 von von PROPN dti-1357 433 2 mering mere VERB dti-1357 433 3 c c PROPN dti-1357 433 4 , , PUNCT dti-1357 433 5 huynen huynen PROPN dti-1357 433 6 m m PROPN dti-1357 433 7 , , PUNCT dti-1357 433 8 jaeggi jaeggi PROPN dti-1357 433 9 d d PROPN dti-1357 433 10 , , PUNCT dti-1357 433 11 schmidt schmidt PROPN dti-1357 433 12 s s PROPN dti-1357 433 13 , , PUNCT dti-1357 433 14 bork bork NOUN dti-1357 433 15 p p PROPN dti-1357 433 16 , , PUNCT dti-1357 433 17 snel snel PROPN dti-1357 433 18 b. b. PROPN dti-1357 433 19 string string PROPN dti-1357 433 20 : : PUNCT dti-1357 433 21 a a DET dti-1357 433 22 database database NOUN dti-1357 433 23 of of ADP dti-1357 433 24 predicted predict VERB dti-1357 433 25 functional functional ADJ dti-1357 433 26 associations association NOUN dti-1357 433 27 between between ADP dti-1357 433 28 proteins protein NOUN dti-1357 433 29 . . PUNCT dti-1357 434 1 nucleic nucleic ADJ dti-1357 434 2 acids acid NOUN dti-1357 434 3 res re NOUN dti-1357 434 4 . . PUNCT dti-1357 435 1 2003;31(1):258–261 2003;31(1):258–261 NUM dti-1357 435 2 . . PROPN dti-1357 435 3 38 38 NUM dti-1357 435 4 . . PUNCT dti-1357 436 1 knox knox PROPN dti-1357 436 2 c c PROPN dti-1357 436 3 , , PUNCT dti-1357 436 4 law law NOUN dti-1357 436 5 v v NOUN dti-1357 436 6 , , PUNCT dti-1357 436 7 jewison jewison PROPN dti-1357 436 8 t t PROPN dti-1357 436 9 , , PUNCT dti-1357 436 10 et et PROPN dti-1357 436 11 al al PROPN dti-1357 436 12 . . PROPN dti-1357 436 13 drugbank drugbank PROPN dti-1357 436 14 3.0 3.0 NUM dti-1357 436 15 : : PUNCT dti-1357 436 16 a a DET dti-1357 436 17 comprehensive comprehensive ADJ dti-1357 436 18 resource resource NOUN dti-1357 436 19 for for ADP dti-1357 436 20 ‘ ' PUNCT dti-1357 436 21 omics omic NOUN dti-1357 436 22 ’ ' PUNCT dti-1357 436 23 research research NOUN dti-1357 436 24 on on ADP dti-1357 436 25 drugs drug NOUN dti-1357 436 26 . . PUNCT dti-1357 437 1 nucleic nucleic ADJ dti-1357 437 2 acids acid NOUN dti-1357 437 3 res re NOUN dti-1357 437 4 . . PROPN dti-1357 438 1 2011;39(database 2011;39(database PROPN dti-1357 438 2 issue):d1035 issue):d1035 PROPN dti-1357 438 3 – – PUNCT dti-1357 438 4 d1041 d1041 NOUN dti-1357 438 5 . . PROPN dti-1357 439 1 39 39 NUM dti-1357 439 2 . . PUNCT dti-1357 440 1 hasan hasan PROPN dti-1357 440 2 s s PROPN dti-1357 440 3 , , PUNCT dti-1357 440 4 daugelat daugelat PROPN dti-1357 440 5 s s PROPN dti-1357 440 6 , , PUNCT dti-1357 440 7 rao rao PROPN dti-1357 440 8 ps ps PROPN dti-1357 440 9 , , PUNCT dti-1357 440 10 schreiber schreiber PROPN dti-1357 440 11 m. m. NOUN dti-1357 440 12 prioritizing prioritize VERB dti-1357 440 13 genomic genomic ADJ dti-1357 440 14 drug drug NOUN dti-1357 440 15 targets target NOUN dti-1357 440 16 in in ADP dti-1357 440 17 pathogens pathogen NOUN dti-1357 440 18 : : PUNCT dti-1357 440 19 application application NOUN dti-1357 440 20 to to ADP dti-1357 440 21 mycobacterium mycobacterium NOUN dti-1357 440 22 tuberculosis tuberculosis NOUN dti-1357 440 23 . . PUNCT dti-1357 441 1 plos plos PROPN dti-1357 441 2 comput comput PROPN dti-1357 441 3 biol biol PROPN dti-1357 441 4 . . PUNCT dti-1357 442 1 2006 2006 NUM dti-1357 442 2 ; ; PUNCT dti-1357 442 3 2(6):e61 2(6):e61 NUM dti-1357 442 4 . . PUNCT dti-1357 443 1 40 40 NUM dti-1357 443 2 . . PUNCT dti-1357 444 1 crowther crowther PROPN dti-1357 444 2 gj gj PROPN dti-1357 444 3 , , PUNCT dti-1357 444 4 shanmugam shanmugam PROPN dti-1357 444 5 d d PROPN dti-1357 444 6 , , PUNCT dti-1357 444 7 carmona carmona PROPN dti-1357 444 8 sj sj PROPN dti-1357 444 9 , , PUNCT dti-1357 444 10 et et PROPN dti-1357 444 11 al al PROPN dti-1357 444 12 . . PUNCT dti-1357 444 13 identification identification NOUN dti-1357 444 14 of of ADP dti-1357 444 15 attractive attractive ADJ dti-1357 444 16 drug drug NOUN dti-1357 444 17 targets target NOUN dti-1357 444 18 in in ADP dti-1357 444 19 neglected neglect VERB dti-1357 444 20 - - PUNCT dti-1357 444 21 disease disease NOUN dti-1357 444 22 pathogens pathogen NOUN dti-1357 444 23 using use VERB dti-1357 444 24 an an DET dti-1357 444 25 in in ADP dti-1357 444 26 silico silico NOUN dti-1357 444 27 approach approach NOUN dti-1357 444 28 . . PUNCT dti-1357 445 1 plos plos PROPN dti-1357 445 2 negl negl PROPN dti-1357 445 3 trop trop X dti-1357 445 4 dis dis PROPN dti-1357 445 5 . . PUNCT dti-1357 445 6 2010;4(8):e804 2010;4(8):e804 NOUN dti-1357 445 7 . . PUNCT dti-1357 446 1 41 41 NUM dti-1357 446 2 . . PUNCT dti-1357 447 1 kushwaha kushwaha NOUN dti-1357 447 2 sk sk PROPN dti-1357 447 3 , , PUNCT dti-1357 447 4 shakya shakya PROPN dti-1357 447 5 m. m. NOUN dti-1357 447 6 protein protein NOUN dti-1357 447 7 interaction interaction NOUN dti-1357 447 8 network network NOUN dti-1357 447 9 analysis analysis NOUN dti-1357 447 10 — — PUNCT dti-1357 447 11 approach approach NOUN dti-1357 447 12 for for ADP dti-1357 447 13 potential potential ADJ dti-1357 447 14 drug drug NOUN dti-1357 447 15 target target NOUN dti-1357 447 16 identification identification NOUN dti-1357 447 17 in in ADP dti-1357 447 18 mycobacterium mycobacterium NOUN dti-1357 447 19 tuberculosis tuberculosis NOUN dti-1357 447 20 . . PUNCT dti-1357 448 1 j j PROPN dti-1357 448 2 theor theor PROPN dti-1357 448 3 biol biol PROPN dti-1357 448 4 . . PUNCT dti-1357 449 1 2010 2010 NUM dti-1357 449 2 ; ; PUNCT dti-1357 449 3 262(2):284–294 262(2):284–294 NUM dti-1357 449 4 . . PUNCT dti-1357 450 1 42 42 NUM dti-1357 450 2 . . PUNCT dti-1357 451 1 cui cui PROPN dti-1357 451 2 t t PROPN dti-1357 451 3 , , PUNCT dti-1357 451 4 zhang zhang PROPN dti-1357 451 5 l l PROPN dti-1357 451 6 , , PUNCT dti-1357 451 7 wang wang PROPN dti-1357 451 8 x x PROPN dti-1357 451 9 , , PUNCT dti-1357 451 10 he he PRON dti-1357 451 11 zg zg PROPN dti-1357 451 12 . . PUNCT dti-1357 451 13 uncovering uncover VERB dti-1357 451 14 new new ADJ dti-1357 451 15 signaling signal VERB dti-1357 451 16 proteins protein NOUN dti-1357 451 17 and and CCONJ dti-1357 451 18 potential potential ADJ dti-1357 451 19 drug drug NOUN dti-1357 451 20 targets target NOUN dti-1357 451 21 through through ADP dti-1357 451 22 the the DET dti-1357 451 23 interactome interactome NOUN dti-1357 451 24 analysis analysis NOUN dti-1357 451 25 of of ADP dti-1357 451 26 mycobacterium mycobacterium NOUN dti-1357 451 27 tuberculosis tuberculosis NOUN dti-1357 451 28 . . PUNCT dti-1357 452 1 bmc bmc ADJ dti-1357 452 2 genomics genomic NOUN dti-1357 452 3 . . PUNCT dti-1357 453 1 2009;10:118 2009;10:118 NUM dti-1357 453 2 . . PROPN dti-1357 454 1 43 43 NUM dti-1357 454 2 . . PUNCT dti-1357 455 1 maguire maguire PROPN dti-1357 455 2 ba ba PROPN dti-1357 455 3 . . PUNCT dti-1357 456 1 inhibition inhibition NOUN dti-1357 456 2 of of ADP dti-1357 456 3 bacterial bacterial ADJ dti-1357 456 4 ribosome ribosome NOUN dti-1357 456 5 assembly assembly NOUN dti-1357 456 6 : : PUNCT dti-1357 456 7 a a DET dti-1357 456 8 suitable suitable ADJ dti-1357 456 9 drug drug NOUN dti-1357 456 10 target target NOUN dti-1357 456 11 ? ? PUNCT dti-1357 457 1 microbiol microbiol PROPN dti-1357 457 2 mol mol ADP dti-1357 457 3 biol biol PROPN dti-1357 457 4 rev rev PROPN dti-1357 457 5 . . PROPN dti-1357 458 1 2009;73(1):22–35 2009;73(1):22–35 NUM dti-1357 458 2 . . NOUN dti-1357 458 3 44 44 NUM dti-1357 458 4 . . PUNCT dti-1357 459 1 samant samant PROPN dti-1357 459 2 s s PROPN dti-1357 459 3 , , PUNCT dti-1357 459 4 lee lee PROPN dti-1357 459 5 h h PROPN dti-1357 459 6 , , PUNCT dti-1357 459 7 ghassemi ghassemi PROPN dti-1357 459 8 m m PROPN dti-1357 459 9 , , PUNCT dti-1357 459 10 et et PROPN dti-1357 459 11 al al PROPN dti-1357 459 12 . . PROPN dti-1357 459 13 nucleotide nucleotide PROPN dti-1357 459 14 biosynthesis biosynthesis NOUN dti-1357 459 15 is be AUX dti-1357 459 16 critical critical ADJ dti-1357 459 17 for for ADP dti-1357 459 18 growth growth NOUN dti-1357 459 19 of of ADP dti-1357 459 20 bacteria bacteria NOUN dti-1357 459 21 in in ADP dti-1357 459 22 human human ADJ dti-1357 459 23 blood blood NOUN dti-1357 459 24 . . PUNCT dti-1357 460 1 plos plos PROPN dti-1357 460 2 pathog pathog PROPN dti-1357 460 3 . . PUNCT dti-1357 461 1 2008;4(2):e37 2008;4(2):e37 X dti-1357 461 2 . . X dti-1357 461 3 45 45 NUM dti-1357 461 4 . . X dti-1357 461 5 hurdle hurdle PROPN dti-1357 461 6 jg jg PROPN dti-1357 461 7 , , PUNCT dti-1357 461 8 o’neill o’neill PROPN dti-1357 461 9 aj aj PROPN dti-1357 461 10 , , PUNCT dti-1357 461 11 chopra chopra PROPN dti-1357 461 12 i. i. PROPN dti-1357 461 13 prospects prospect NOUN dti-1357 461 14 for for ADP dti-1357 461 15 aminoacyl aminoacyl NOUN dti-1357 461 16 - - PUNCT dti-1357 461 17 trna trna ADJ dti-1357 461 18 synthetase synthetase NOUN dti-1357 461 19 inhibitors inhibitor NOUN dti-1357 461 20 as as ADP dti-1357 461 21 new new ADJ dti-1357 461 22 antimicrobial antimicrobial ADJ dti-1357 461 23 agents agent NOUN dti-1357 461 24 . . PUNCT dti-1357 462 1 antimicrob antimicrob PROPN dti-1357 462 2 agents agents PROPN dti-1357 462 3 chemother chemother PROPN dti-1357 462 4 . . PUNCT dti-1357 463 1 2005;49(12):4821–4833 2005;49(12):4821–4833 X dti-1357 463 2 . . PROPN dti-1357 464 1 46 46 NUM dti-1357 464 2 . . PUNCT dti-1357 465 1 beyer beyer PROPN dti-1357 465 2 d d PROPN dti-1357 465 3 , , PUNCT dti-1357 465 4 kroll kroll PROPN dti-1357 465 5 hp hp PROPN dti-1357 465 6 , , PUNCT dti-1357 465 7 endermann endermann NOUN dti-1357 465 8 r r NOUN dti-1357 465 9 , , PUNCT dti-1357 465 10 et et PROPN dti-1357 465 11 al al PROPN dti-1357 465 12 . . PUNCT dti-1357 466 1 new new ADJ dti-1357 466 2 class class NOUN dti-1357 466 3 of of ADP dti-1357 466 4 bacterial bacterial ADJ dti-1357 466 5 phenylalanyltrna phenylalanyltrna NOUN dti-1357 466 6 synthetase synthetase NOUN dti-1357 466 7 inhibitors inhibitor NOUN dti-1357 466 8 with with ADP dti-1357 466 9 high high ADJ dti-1357 466 10 potency potency NOUN dti-1357 466 11 and and CCONJ dti-1357 466 12 broad broad ADJ dti-1357 466 13 - - PUNCT dti-1357 466 14 spectrum spectrum NOUN dti-1357 466 15 activity activity NOUN dti-1357 466 16 . . PUNCT dti-1357 467 1 antimicrob antimicrob PROPN dti-1357 467 2 agents agents PROPN dti-1357 467 3 chemother chemother PROPN dti-1357 467 4 . . PUNCT dti-1357 468 1 2004;48(2):525–532 2004;48(2):525–532 NUM dti-1357 468 2 . . PROPN dti-1357 468 3 47 47 NUM dti-1357 468 4 . . PUNCT dti-1357 469 1 rodaki rodaki PROPN dti-1357 469 2 a a PRON dti-1357 469 3 , , PUNCT dti-1357 469 4 young young ADJ dti-1357 469 5 t t PROPN dti-1357 469 6 , , PUNCT dti-1357 469 7 brown brown PROPN dti-1357 469 8 aj aj PROPN dti-1357 469 9 . . PUNCT dti-1357 470 1 effects effect NOUN dti-1357 470 2 of of ADP dti-1357 470 3 depleting deplete VERB dti-1357 470 4 the the DET dti-1357 470 5 essential essential ADJ dti-1357 470 6 central central ADJ dti-1357 470 7 metabolic metabolic NOUN dti-1357 470 8 enzyme enzyme NOUN dti-1357 470 9 fructose-1,6 fructose-1,6 PROPN dti-1357 470 10 - - PUNCT dti-1357 470 11 bisphosphate bisphosphate NOUN dti-1357 470 12 aldolase aldolase NOUN dti-1357 470 13 on on ADP dti-1357 470 14 the the DET dti-1357 470 15 growth growth NOUN dti-1357 470 16 and and CCONJ dti-1357 470 17 viability viability NOUN dti-1357 470 18 of of ADP dti-1357 470 19 candida candida NOUN dti-1357 470 20 albicans albican NOUN dti-1357 470 21 : : PUNCT dti-1357 470 22 implications implication NOUN dti-1357 470 23 for for ADP dti-1357 470 24 antifungal antifungal ADJ dti-1357 470 25 drug drug NOUN dti-1357 470 26 target target NOUN dti-1357 470 27 discovery discovery NOUN dti-1357 470 28 . . PUNCT dti-1357 471 1 eukaryot eukaryot NOUN dti-1357 471 2 cell cell NOUN dti-1357 471 3 . . PUNCT dti-1357 472 1 2006;5(8 2006;5(8 NUM dti-1357 472 2 ): ): PUNCT dti-1357 472 3 1371–1377 1371–1377 NUM dti-1357 472 4 . . PUNCT dti-1357 472 5 http://www.la-press.com http://www.la-press.com X dti-1357 473 1 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1357 473 2 parvege parvege PROPN dti-1357 473 3 et et PROPN dti-1357 473 4 al al PROPN dti-1357 473 5 62 62 NUM dti-1357 473 6 drug drug NOUN dti-1357 473 7 target target NOUN dti-1357 473 8 insights insight NOUN dti-1357 473 9 2014:8 2014:8 NUM dti-1357 473 10 48 48 NUM dti-1357 473 11 . . PUNCT dti-1357 474 1 zhang zhang PROPN dti-1357 474 2 y y PROPN dti-1357 474 3 , , PUNCT dti-1357 474 4 foster foster PROPN dti-1357 474 5 jm jm PROPN dti-1357 474 6 , , PUNCT dti-1357 474 7 kumar kumar PROPN dti-1357 474 8 s s PROPN dti-1357 474 9 , , PUNCT dti-1357 474 10 fougere fougere NOUN dti-1357 474 11 m m PROPN dti-1357 474 12 , , PUNCT dti-1357 474 13 carlow carlow PROPN dti-1357 474 14 ck ck PROPN dti-1357 474 15 . . PUNCT dti-1357 475 1 cofactor cofactor NOUN dti-1357 475 2 - - PUNCT dti-1357 475 3 independent independent ADJ dti-1357 475 4 phosphoglycerate phosphoglycerate NOUN dti-1357 475 5 mutase mutase NOUN dti-1357 475 6 has have VERB dti-1357 475 7 an an DET dti-1357 475 8 essential essential ADJ dti-1357 475 9 role role NOUN dti-1357 475 10 in in ADP dti-1357 475 11 caenorhabditis caenorhabditis ADJ dti-1357 475 12 elegans elegan NOUN dti-1357 475 13 and and CCONJ dti-1357 475 14 is be AUX dti-1357 475 15 conserved conserve VERB dti-1357 475 16 in in ADP dti-1357 475 17 parasitic parasitic ADJ dti-1357 475 18 nematodes nematode NOUN dti-1357 475 19 . . PUNCT dti-1357 476 1 j j PROPN dti-1357 476 2 biol biol PROPN dti-1357 476 3 chem chem NOUN dti-1357 476 4 . . PUNCT dti-1357 477 1 2004;279(35):37185–37190 2004;279(35):37185–37190 NUM dti-1357 477 2 . . NOUN dti-1357 477 3 49 49 NUM dti-1357 477 4 . . PUNCT dti-1357 478 1 chhabra chhabra PROPN dti-1357 478 2 g g PROPN dti-1357 478 3 , , PUNCT dti-1357 478 4 sharma sharma PROPN dti-1357 478 5 p p PROPN dti-1357 478 6 , , PUNCT dti-1357 478 7 anant anant PROPN dti-1357 478 8 a a PROPN dti-1357 478 9 , , PUNCT dti-1357 478 10 et et PROPN dti-1357 478 11 al al PROPN dti-1357 478 12 . . PUNCT dti-1357 478 13 identification identification NOUN dti-1357 478 14 and and CCONJ dti-1357 478 15 modeling modeling NOUN dti-1357 478 16 of of ADP dti-1357 478 17 a a DET dti-1357 478 18 drug drug NOUN dti-1357 478 19 target target NOUN dti-1357 478 20 for for ADP dti-1357 478 21 clostridium clostridium NOUN dti-1357 478 22 perfringens perfringen NOUN dti-1357 478 23 sm101 sm101 PROPN dti-1357 478 24 . . PUNCT dti-1357 479 1 bioinformation bioinformation NOUN dti-1357 479 2 . . PUNCT dti-1357 480 1 2010;4(7):278–289 2010;4(7):278–289 NUM dti-1357 480 2 . . NOUN dti-1357 481 1 50 50 NUM dti-1357 481 2 . . PUNCT dti-1357 482 1 gotoh gotoh PROPN dti-1357 482 2 y y PROPN dti-1357 482 3 , , PUNCT dti-1357 482 4 eguchi eguchi VERB dti-1357 482 5 y y PROPN dti-1357 482 6 , , PUNCT dti-1357 482 7 watanabe watanabe PROPN dti-1357 482 8 t t PROPN dti-1357 482 9 , , PUNCT dti-1357 482 10 okamoto okamoto PROPN dti-1357 482 11 s s PROPN dti-1357 482 12 , , PUNCT dti-1357 482 13 doi doi X dti-1357 482 14 a a NOUN dti-1357 482 15 , , PUNCT dti-1357 482 16 utsumi utsumi PROPN dti-1357 482 17 r. r. PROPN dti-1357 482 18 two two NUM dti-1357 482 19 - - PUNCT dti-1357 482 20 component component NOUN dti-1357 482 21 signal signal NOUN dti-1357 482 22 transduction transduction NOUN dti-1357 482 23 as as ADP dti-1357 482 24 potential potential ADJ dti-1357 482 25 drug drug NOUN dti-1357 482 26 targets target NOUN dti-1357 482 27 in in ADP dti-1357 482 28 pathogenic pathogenic ADJ dti-1357 482 29 bacteria bacteria NOUN dti-1357 482 30 . . PUNCT dti-1357 483 1 curr curr PROPN dti-1357 483 2 opin opin PROPN dti-1357 483 3 microbiol microbiol PROPN dti-1357 483 4 . . PUNCT dti-1357 484 1 2010;13(2):232–239 2010;13(2):232–239 NUM dti-1357 484 2 . . NOUN dti-1357 484 3 51 51 NUM dti-1357 484 4 . . PUNCT dti-1357 485 1 barh barh PROPN dti-1357 485 2 d d PROPN dti-1357 485 3 , , PUNCT dti-1357 485 4 kumar kumar PROPN dti-1357 485 5 a. a. PROPN dti-1357 485 6 in in ADP dti-1357 485 7 silico silico NOUN dti-1357 485 8 identification identification NOUN dti-1357 485 9 of of ADP dti-1357 485 10 candidate candidate NOUN dti-1357 485 11 drug drug NOUN dti-1357 485 12 and and CCONJ dti-1357 485 13 vaccine vaccine NOUN dti-1357 485 14 targets target NOUN dti-1357 485 15 from from ADP dti-1357 485 16 various various ADJ dti-1357 485 17 pathways pathway NOUN dti-1357 485 18 in in ADP dti-1357 485 19 neisseria neisseria PROPN dti-1357 485 20 gonorrhoeae gonorrhoeae PROPN dti-1357 485 21 . . PUNCT dti-1357 486 1 in in ADP dti-1357 486 2 silico silico NOUN dti-1357 486 3 biol biol NOUN dti-1357 486 4 . . PUNCT dti-1357 487 1 2009;9(4):225–231 2009;9(4):225–231 NUM dti-1357 487 2 . . PROPN dti-1357 487 3 52 52 NUM dti-1357 487 4 . . PUNCT dti-1357 487 5 chong chong PROPN dti-1357 487 6 ce ce PROPN dti-1357 487 7 , , PUNCT dti-1357 487 8 lim lim PROPN dti-1357 487 9 bs bs PROPN dti-1357 487 10 , , PUNCT dti-1357 487 11 nathan nathan PROPN dti-1357 487 12 s s PROPN dti-1357 487 13 , , PUNCT dti-1357 487 14 mohamed mohamed PROPN dti-1357 487 15 r. r. PROPN dti-1357 487 16 in in ADP dti-1357 487 17 silico silico NOUN dti-1357 487 18 analysis analysis NOUN dti-1357 487 19 of of ADP dti-1357 487 20 burkholderia burkholderia NOUN dti-1357 487 21 pseudomallei pseudomallei NOUN dti-1357 487 22 genome genome NOUN dti-1357 487 23 sequence sequence NOUN dti-1357 487 24 for for ADP dti-1357 487 25 potential potential ADJ dti-1357 487 26 drug drug NOUN dti-1357 487 27 targets target NOUN dti-1357 487 28 . . PUNCT dti-1357 488 1 in in ADP dti-1357 488 2 silico silico NOUN dti-1357 488 3 biol biol NOUN dti-1357 488 4 . . PUNCT dti-1357 489 1 2006;6(4 2006;6(4 NUM dti-1357 489 2 ): ): PUNCT dti-1357 489 3 341–346 341–346 NUM dti-1357 489 4 . . PUNCT dti-1357 490 1 53 53 NUM dti-1357 490 2 . . PUNCT dti-1357 491 1 duncan duncan PROPN dti-1357 491 2 mc mc PROPN dti-1357 491 3 , , PUNCT dti-1357 491 4 linington linington PROPN dti-1357 491 5 rg rg PROPN dti-1357 491 6 , , PUNCT dti-1357 491 7 auerbuch auerbuch ADV dti-1357 491 8 v. v. ADP dti-1357 491 9 chemical chemical ADJ dti-1357 491 10 inhibitors inhibitor NOUN dti-1357 491 11 of of ADP dti-1357 491 12 the the DET dti-1357 491 13 type type NOUN dti-1357 491 14 three three NUM dti-1357 491 15 secretion secretion NOUN dti-1357 491 16 system system NOUN dti-1357 491 17 : : PUNCT dti-1357 491 18 disarming disarm VERB dti-1357 491 19 bacterial bacterial ADJ dti-1357 491 20 pathogens pathogen NOUN dti-1357 491 21 . . PUNCT dti-1357 492 1 antimicrob antimicrob PROPN dti-1357 492 2 agents agents PROPN dti-1357 492 3 chemother chemother PROPN dti-1357 492 4 . . PUNCT dti-1357 493 1 2012 2012 NUM dti-1357 493 2 ; ; PUNCT dti-1357 494 1 56(11):5433–5441 56(11):5433–5441 NUM dti-1357 494 2 . . NOUN dti-1357 494 3 54 54 NUM dti-1357 494 4 . . PUNCT dti-1357 494 5 felise felise PROPN dti-1357 494 6 hb hb PROPN dti-1357 494 7 , , PUNCT dti-1357 494 8 nguyen nguyen PROPN dti-1357 494 9 hv hv PROPN dti-1357 494 10 , , PUNCT dti-1357 494 11 pfuetzner pfuetzner NOUN dti-1357 494 12 ra ra PROPN dti-1357 494 13 , , PUNCT dti-1357 494 14 et et PROPN dti-1357 494 15 al al PROPN dti-1357 494 16 . . PUNCT dti-1357 495 1 an an DET dti-1357 495 2 inhibitor inhibitor NOUN dti-1357 495 3 of of ADP dti-1357 495 4 gram gram NOUN dti-1357 495 5 - - PUNCT dti-1357 495 6 negative negative ADJ dti-1357 495 7 bacterial bacterial ADJ dti-1357 495 8 virulence virulence NOUN dti-1357 495 9 protein protein NOUN dti-1357 495 10 secretion secretion NOUN dti-1357 495 11 . . PUNCT dti-1357 496 1 cell cell NOUN dti-1357 496 2 host host NOUN dti-1357 496 3 microbe microbe NOUN dti-1357 496 4 . . PUNCT dti-1357 497 1 2008;4(4):325–336 2008;4(4):325–336 X dti-1357 497 2 . . PUNCT dti-1357 498 1 55 55 NUM dti-1357 498 2 . . PUNCT dti-1357 499 1 koster koster PROPN dti-1357 499 2 w. w. PROPN dti-1357 499 3 abc abc PROPN dti-1357 499 4 transporter transporter NOUN dti-1357 499 5 - - PUNCT dti-1357 499 6 mediated mediate VERB dti-1357 499 7 uptake uptake NOUN dti-1357 499 8 of of ADP dti-1357 499 9 iron iron NOUN dti-1357 499 10 , , PUNCT dti-1357 499 11 siderophores siderophore NOUN dti-1357 499 12 , , PUNCT dti-1357 499 13 heme heme NOUN dti-1357 499 14 and and CCONJ dti-1357 499 15 vitamin vitamin NOUN dti-1357 499 16 b12 b12 NOUN dti-1357 499 17 . . PUNCT dti-1357 500 1 res re NOUN dti-1357 500 2 microbiol microbiol PROPN dti-1357 500 3 . . PUNCT dti-1357 501 1 2001;152(3–4):291–301 2001;152(3–4):291–301 NUM dti-1357 501 2 . . PUNCT dti-1357 502 1 56 56 NUM dti-1357 502 2 . . PUNCT dti-1357 503 1 van van PROPN dti-1357 503 2 veen veen PROPN dti-1357 503 3 hw hw PROPN dti-1357 503 4 , , PUNCT dti-1357 503 5 higgins higgins PROPN dti-1357 503 6 cf cf PROPN dti-1357 503 7 , , PUNCT dti-1357 503 8 konings koning NOUN dti-1357 503 9 wn wn PROPN dti-1357 503 10 . . PROPN dti-1357 503 11 multidrug multidrug VERB dti-1357 503 12 transport transport NOUN dti-1357 503 13 by by ADP dti-1357 503 14 atp atp NOUN dti-1357 503 15 binding bind VERB dti-1357 503 16 cassette cassette NOUN dti-1357 503 17 transporters transporter NOUN dti-1357 503 18 : : PUNCT dti-1357 503 19 a a DET dti-1357 503 20 proposed propose VERB dti-1357 503 21 two two NUM dti-1357 503 22 - - PUNCT dti-1357 503 23 cylinder cylinder NOUN dti-1357 503 24 engine engine NOUN dti-1357 503 25 mechanism mechanism NOUN dti-1357 503 26 . . PUNCT dti-1357 504 1 res re NOUN dti-1357 504 2 microbiol microbiol PROPN dti-1357 504 3 . . PUNCT dti-1357 505 1 2001;152(3–4):365–374 2001;152(3–4):365–374 NUM dti-1357 505 2 . . PUNCT dti-1357 506 1 57 57 NUM dti-1357 506 2 . . X dti-1357 507 1 garmory garmory PROPN dti-1357 507 2 hs hs PROPN dti-1357 507 3 , , PUNCT dti-1357 507 4 titball titball PROPN dti-1357 507 5 rw rw PROPN dti-1357 507 6 . . PUNCT dti-1357 507 7 atp atp PROPN dti-1357 507 8 - - PUNCT dti-1357 507 9 binding bind VERB dti-1357 507 10 cassette cassette NOUN dti-1357 507 11 transporters transporter NOUN dti-1357 507 12 are be AUX dti-1357 507 13 targets target NOUN dti-1357 507 14 for for ADP dti-1357 507 15 the the DET dti-1357 507 16 development development NOUN dti-1357 507 17 of of ADP dti-1357 507 18 antibacterial antibacterial ADJ dti-1357 507 19 vaccines vaccine NOUN dti-1357 507 20 and and CCONJ dti-1357 507 21 therapies therapy NOUN dti-1357 507 22 . . PUNCT dti-1357 508 1 infect infect VERB dti-1357 508 2 immun immun PROPN dti-1357 508 3 . . PUNCT dti-1357 509 1 2004;72(12 2004;72(12 NUM dti-1357 509 2 ): ): PUNCT dti-1357 509 3 6757–6763 6757–6763 NUM dti-1357 509 4 . . PUNCT dti-1357 510 1 http://www.la-press.com http://www.la-press.com X dti-1357 510 2 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN