id	sid	tid	token	lemma	pos
dti-1373	1	1	drug	drug	NOUN
dti-1373	1	2	target	target	NOUN
dti-1373	1	3	insights	insight	NOUN
dti-1373	1	4	2012:6	2012:6	NUM
dti-1373	1	5	1–11	1–11	PROPN
dti-1373	1	6	doi	doi	NOUN
dti-1373	1	7	:	:	PUNCT
dti-1373	1	8	10.4137	10.4137	NUM
dti-1373	1	9	/	/	SYM
dti-1373	1	10	dti.s9442	dti.s9442	VERB
dti-1373	1	11	this	this	DET
dti-1373	1	12	article	article	NOUN
dti-1373	1	13	is	be	AUX
dti-1373	1	14	available	available	ADJ
dti-1373	1	15	from	from	ADP
dti-1373	1	16	http://www.la-press.com	http://www.la-press.com	X
dti-1373	1	17	.	.	PUNCT
dti-1373	2	1	©	©	ADP
dti-1373	2	2	the	the	DET
dti-1373	2	3	author(s	author(s	PROPN
dti-1373	2	4	)	)	PUNCT
dti-1373	2	5	,	,	PUNCT
dti-1373	2	6	publisher	publisher	NOUN
dti-1373	2	7	and	and	CCONJ
dti-1373	2	8	licensee	licensee	PROPN
dti-1373	2	9	libertas	libertas	PROPN
dti-1373	2	10	academica	academica	PROPN
dti-1373	2	11	ltd	ltd	PROPN
dti-1373	2	12	.	.	PUNCT
dti-1373	3	1	this	this	PRON
dti-1373	3	2	is	be	AUX
dti-1373	3	3	an	an	DET
dti-1373	3	4	open	open	ADJ
dti-1373	3	5	access	access	NOUN
dti-1373	3	6	article	article	NOUN
dti-1373	3	7	.	.	PUNCT
dti-1373	4	1	unrestricted	unrestricted	ADJ
dti-1373	4	2	non	non	ADJ
dti-1373	4	3	-	-	ADJ
dti-1373	4	4	commercial	commercial	ADJ
dti-1373	4	5	use	use	NOUN
dti-1373	4	6	is	be	AUX
dti-1373	4	7	permitted	permit	VERB
dti-1373	4	8	provided	provide	VERB
dti-1373	4	9	the	the	DET
dti-1373	4	10	original	original	ADJ
dti-1373	4	11	work	work	NOUN
dti-1373	4	12	is	be	AUX
dti-1373	4	13	properly	properly	ADV
dti-1373	4	14	cited	cite	VERB
dti-1373	4	15	.	.	PUNCT
dti-1373	5	1	open	open	ADJ
dti-1373	5	2	access	access	NOUN
dti-1373	5	3	full	full	ADJ
dti-1373	5	4	open	open	ADJ
dti-1373	5	5	access	access	NOUN
dti-1373	5	6	to	to	ADP
dti-1373	5	7	this	this	PRON
dti-1373	5	8	and	and	CCONJ
dti-1373	5	9	thousands	thousand	NOUN
dti-1373	5	10	of	of	ADP
dti-1373	5	11	other	other	ADJ
dti-1373	5	12	papers	paper	NOUN
dti-1373	5	13	at	at	ADP
dti-1373	5	14	http://www.la-press.com	http://www.la-press.com	X
dti-1373	5	15	.	.	PUNCT
dti-1373	6	1	drug	drug	NOUN
dti-1373	6	2	target	target	NOUN
dti-1373	6	3	insights	insight	NOUN
dti-1373	6	4	o	o	NOUN
dti-1373	6	5	r	r	NOUN
dti-1373	7	1	i	i	PRON
dti-1373	7	2	g	g	VERB
dti-1373	8	1	i	i	PRON
dti-1373	8	2	n	n	CCONJ
dti-1373	8	3	a	a	DET
dti-1373	8	4	l	l	NOUN
dti-1373	8	5	r	r	NOUN
dti-1373	8	6	e	e	NOUN
dti-1373	8	7	s	s	X
dti-1373	8	8	e	e	X
dti-1373	8	9	a	a	DET
dti-1373	8	10	r	r	NOUN
dti-1373	8	11	c	c	NOUN
dti-1373	8	12	h	h	NOUN
dti-1373	8	13	drug	drug	NOUN
dti-1373	8	14	target	target	NOUN
dti-1373	8	15	insights	insight	NOUN
dti-1373	8	16	2012:6	2012:6	NUM
dti-1373	8	17	1	1	NUM
dti-1373	8	18	resveratrol	resveratrol	NOUN
dti-1373	8	19	targeting	targeting	NOUN
dti-1373	8	20	of	of	ADP
dti-1373	8	21	carcinogen	carcinogen	NOUN
dti-1373	8	22	-	-	PUNCT
dti-1373	8	23	induced	induce	VERB
dti-1373	8	24	brain	brain	NOUN
dti-1373	8	25	endothelial	endothelial	ADJ
dti-1373	8	26	cell	cell	NOUN
dti-1373	8	27	inflammation	inflammation	NOUN
dti-1373	8	28	biomarkers	biomarker	NOUN
dti-1373	8	29	mmp-9	mmp-9	VERB
dti-1373	8	30	and	and	CCONJ
dti-1373	8	31	cox-2	cox-2	PRON
dti-1373	8	32	is	be	AUX
dti-1373	8	33	sirt1	sirt1	ADJ
dti-1373	8	34	-	-	ADJ
dti-1373	8	35	independent	independent	ADJ
dti-1373	8	36	borhane	borhane	PROPN
dti-1373	8	37	annabi1	annabi1	PROPN
dti-1373	8	38	,	,	PUNCT
dti-1373	8	39	simon	simon	PROPN
dti-1373	8	40	lord	lord	PROPN
dti-1373	8	41	-	-	PUNCT
dti-1373	8	42	dufour2	dufour2	PROPN
dti-1373	8	43	,	,	PUNCT
dti-1373	8	44	amélie	amélie	PROPN
dti-1373	8	45	vézina1	vézina1	PROPN
dti-1373	8	46	and	and	CCONJ
dti-1373	8	47	richard	richard	PROPN
dti-1373	8	48	béliveau2	béliveau2	PROPN
dti-1373	9	1	1laboratoire	1laboratoire	NUM
dti-1373	9	2	d’oncologie	d’oncologie	NOUN
dti-1373	9	3	moléculaire	moléculaire	NOUN
dti-1373	9	4	,	,	PUNCT
dti-1373	9	5	2laboratoire	2laboratoire	NUM
dti-1373	9	6	de	de	X
dti-1373	9	7	médecine	médecine	NOUN
dti-1373	9	8	moléculaire	moléculaire	NOUN
dti-1373	9	9	,	,	PUNCT
dti-1373	9	10	centre	centre	PROPN
dti-1373	9	11	de	de	X
dti-1373	9	12	recherche	recherche	X
dti-1373	9	13	biomed	biome	VERB
dti-1373	9	14	,	,	PUNCT
dti-1373	9	15	université	université	PROPN
dti-1373	9	16	du	du	PROPN
dti-1373	9	17	québec	québec	PROPN
dti-1373	9	18	à	à	PROPN
dti-1373	9	19	montréal	montréal	PROPN
dti-1373	9	20	,	,	PUNCT
dti-1373	9	21	quebec	quebec	PROPN
dti-1373	9	22	,	,	PUNCT
dti-1373	9	23	canada	canada	PROPN
dti-1373	9	24	.	.	PUNCT
dti-1373	10	1	corresponding	correspond	VERB
dti-1373	10	2	author	author	NOUN
dti-1373	10	3	email	email	NOUN
dti-1373	10	4	:	:	PUNCT
dti-1373	10	5	annabi.borhane@uqam.ca	annabi.borhane@uqam.ca	NOUN
dti-1373	10	6	abstract	abstract	NOUN
dti-1373	10	7	:	:	PUNCT
dti-1373	10	8	the	the	DET
dti-1373	10	9	occurrence	occurrence	NOUN
dti-1373	10	10	of	of	ADP
dti-1373	10	11	a	a	DET
dti-1373	10	12	functional	functional	ADJ
dti-1373	10	13	relationship	relationship	NOUN
dti-1373	10	14	between	between	ADP
dti-1373	10	15	the	the	DET
dti-1373	10	16	release	release	NOUN
dti-1373	10	17	of	of	ADP
dti-1373	10	18	metalloproteinases	metalloproteinase	NOUN
dti-1373	10	19	(	(	PUNCT
dti-1373	10	20	mmps	mmp	NOUN
dti-1373	10	21	)	)	PUNCT
dti-1373	10	22	and	and	CCONJ
dti-1373	10	23	the	the	DET
dti-1373	10	24	expression	expression	NOUN
dti-1373	10	25	of	of	ADP
dti-1373	10	26	cyclooxygenase	cyclooxygenase	NOUN
dti-1373	10	27	(	(	PUNCT
dti-1373	10	28	cox)-2	cox)-2	PROPN
dti-1373	10	29	,	,	PUNCT
dti-1373	10	30	two	two	NUM
dti-1373	10	31	inducible	inducible	ADJ
dti-1373	10	32	pro	pro	ADJ
dti-1373	10	33	-	-	ADJ
dti-1373	10	34	inflammatory	inflammatory	ADJ
dti-1373	10	35	biomarkers	biomarker	NOUN
dti-1373	10	36	with	with	ADP
dti-1373	10	37	important	important	ADJ
dti-1373	10	38	pro	pro	ADJ
dti-1373	10	39	-	-	ADJ
dti-1373	10	40	angiogenic	angiogenic	ADJ
dti-1373	10	41	effects	effect	NOUN
dti-1373	10	42	,	,	PUNCT
dti-1373	10	43	has	have	AUX
dti-1373	10	44	recently	recently	ADV
dti-1373	10	45	been	be	AUX
dti-1373	10	46	inferred	infer	VERB
dti-1373	10	47	.	.	PUNCT
dti-1373	11	1	while	while	SCONJ
dti-1373	11	2	brain	brain	NOUN
dti-1373	11	3	endothelial	endothelial	NOUN
dti-1373	11	4	cells	cell	NOUN
dti-1373	11	5	play	play	VERB
dti-1373	11	6	an	an	DET
dti-1373	11	7	essential	essential	ADJ
dti-1373	11	8	role	role	NOUN
dti-1373	11	9	as	as	ADP
dti-1373	11	10	structural	structural	ADJ
dti-1373	11	11	and	and	CCONJ
dti-1373	11	12	functional	functional	ADJ
dti-1373	11	13	components	component	NOUN
dti-1373	11	14	of	of	ADP
dti-1373	11	15	the	the	DET
dti-1373	11	16	blood	blood	NOUN
dti-1373	11	17	-	-	PUNCT
dti-1373	11	18	brain	brain	NOUN
dti-1373	11	19	barrier	barrier	NOUN
dti-1373	11	20	(	(	PUNCT
dti-1373	11	21	bbb	bbb	PROPN
dti-1373	11	22	)	)	PUNCT
dti-1373	11	23	,	,	PUNCT
dti-1373	11	24	increased	increase	VERB
dti-1373	11	25	bbb	bbb	NOUN
dti-1373	11	26	breakdown	breakdown	NOUN
dti-1373	11	27	is	be	AUX
dti-1373	11	28	thought	think	VERB
dti-1373	11	29	to	to	PART
dti-1373	11	30	be	be	AUX
dti-1373	11	31	linked	link	VERB
dti-1373	11	32	to	to	ADP
dti-1373	11	33	neuroinflammation	neuroinflammation	NOUN
dti-1373	11	34	.	.	PUNCT
dti-1373	12	1	chemopreventive	chemopreventive	ADJ
dti-1373	12	2	mechanisms	mechanism	NOUN
dti-1373	12	3	targeting	target	VERB
dti-1373	12	4	both	both	DET
dti-1373	12	5	mmps	mmp	NOUN
dti-1373	12	6	and	and	CCONJ
dti-1373	12	7	cox-2	cox-2	NOUN
dti-1373	12	8	however	however	ADV
dti-1373	12	9	remain	remain	VERB
dti-1373	12	10	poorly	poorly	ADV
dti-1373	12	11	investigated	investigate	VERB
dti-1373	12	12	.	.	PUNCT
dti-1373	13	1	in	in	ADP
dti-1373	13	2	this	this	DET
dti-1373	13	3	study	study	NOUN
dti-1373	13	4	,	,	PUNCT
dti-1373	13	5	we	we	PRON
dti-1373	13	6	evaluated	evaluate	VERB
dti-1373	13	7	the	the	DET
dti-1373	13	8	pharmacological	pharmacological	NOUN
dti-1373	13	9	targeting	targeting	NOUN
dti-1373	13	10	of	of	ADP
dti-1373	13	11	sirt1	sirt1	NOUN
dti-1373	13	12	by	by	ADP
dti-1373	13	13	the	the	DET
dti-1373	13	14	diet	diet	NOUN
dti-1373	13	15	-	-	PUNCT
dti-1373	13	16	derived	derive	VERB
dti-1373	13	17	and	and	CCONJ
dti-1373	13	18	antiinflammatory	antiinflammatory	NOUN
dti-1373	13	19	polyphenol	polyphenol	NOUN
dti-1373	13	20	resveratrol	resveratrol	NOUN
dti-1373	13	21	.	.	PUNCT
dti-1373	14	1	total	total	ADJ
dti-1373	14	2	rna	rna	PROPN
dti-1373	14	3	,	,	PUNCT
dti-1373	14	4	cell	cell	NOUN
dti-1373	14	5	lysates	lysate	NOUN
dti-1373	14	6	,	,	PUNCT
dti-1373	14	7	and	and	CCONJ
dti-1373	14	8	conditioned	condition	VERB
dti-1373	14	9	culture	culture	NOUN
dti-1373	14	10	media	medium	NOUN
dti-1373	14	11	from	from	ADP
dti-1373	14	12	human	human	ADJ
dti-1373	14	13	brain	brain	NOUN
dti-1373	14	14	microvascular	microvascular	NOUN
dti-1373	14	15	endothelial	endothelial	ADJ
dti-1373	14	16	cells	cell	NOUN
dti-1373	14	17	(	(	PUNCT
dti-1373	14	18	hbmec	hbmec	PROPN
dti-1373	14	19	)	)	PUNCT
dti-1373	14	20	were	be	AUX
dti-1373	14	21	analyzed	analyze	VERB
dti-1373	14	22	using	use	VERB
dti-1373	14	23	qrt	qrt	NOUN
dti-1373	14	24	-	-	PUNCT
dti-1373	14	25	pcr	pcr	ADJ
dti-1373	14	26	,	,	PUNCT
dti-1373	14	27	immunoblotting	immunoblotte	VERB
dti-1373	14	28	,	,	PUNCT
dti-1373	14	29	and	and	CCONJ
dti-1373	14	30	zymography	zymography	PROPN
dti-1373	14	31	respectively	respectively	ADV
dti-1373	14	32	.	.	PUNCT
dti-1373	15	1	tissue	tissue	NOUN
dti-1373	15	2	scan	scan	AUX
dti-1373	15	3	microarray	microarray	VERB
dti-1373	15	4	analysis	analysis	NOUN
dti-1373	15	5	of	of	ADP
dti-1373	15	6	grade	grade	NOUN
dti-1373	15	7	i	i	PROPN
dti-1373	15	8	–	–	PUNCT
dti-1373	15	9	iv	iv	NUM
dti-1373	15	10	brain	brain	NOUN
dti-1373	15	11	tumours	tumours	PROPN
dti-1373	15	12	cdna	cdna	PROPN
dti-1373	15	13	revealed	reveal	VERB
dti-1373	15	14	increased	increase	VERB
dti-1373	15	15	gene	gene	NOUN
dti-1373	15	16	expression	expression	NOUN
dti-1373	15	17	of	of	ADP
dti-1373	15	18	sirt-1	sirt-1	NUM
dti-1373	15	19	from	from	ADP
dti-1373	15	20	grade	grade	NOUN
dti-1373	15	21	i	i	PROPN
dti-1373	15	22	–	–	PUNCT
dti-1373	15	23	iii	iii	NOUN
dti-1373	15	24	but	but	CCONJ
dti-1373	15	25	surprisingly	surprisingly	ADV
dti-1373	15	26	not	not	PART
dti-1373	15	27	in	in	ADP
dti-1373	15	28	grade	grade	NOUN
dti-1373	15	29	iv	iv	NUM
dti-1373	15	30	brain	brain	NOUN
dti-1373	15	31	tumours	tumours	NOUN
dti-1373	15	32	.	.	PUNCT
dti-1373	16	1	hbmec	hbmec	PROPN
dti-1373	16	2	were	be	AUX
dti-1373	16	3	treated	treat	VERB
dti-1373	16	4	with	with	ADP
dti-1373	16	5	a	a	DET
dti-1373	16	6	combination	combination	NOUN
dti-1373	16	7	of	of	ADP
dti-1373	16	8	resveratrol	resveratrol	NOUN
dti-1373	16	9	and	and	CCONJ
dti-1373	16	10	phorbol	phorbol	NOUN
dti-1373	16	11	12	12	NUM
dti-1373	16	12	-	-	PUNCT
dti-1373	16	13	myristate	myristate	ADJ
dti-1373	16	14	13	13	NUM
dti-1373	16	15	-	-	PUNCT
dti-1373	16	16	acetate	acetate	NOUN
dti-1373	16	17	(	(	PUNCT
dti-1373	16	18	pma	pma	PROPN
dti-1373	16	19	)	)	PUNCT
dti-1373	16	20	,	,	PUNCT
dti-1373	16	21	a	a	DET
dti-1373	16	22	carcinogen	carcinogen	NOUN
dti-1373	16	23	known	know	VERB
dti-1373	16	24	to	to	PART
dti-1373	16	25	increase	increase	VERB
dti-1373	16	26	mmp-9	mmp-9	ADJ
dti-1373	16	27	and	and	CCONJ
dti-1373	16	28	cox-2	cox-2	ADV
dti-1373	16	29	through	through	ADP
dti-1373	16	30	nf	nf	NOUN
dti-1373	16	31	-	-	PUNCT
dti-1373	16	32	κb	κb	NOUN
dti-1373	16	33	.	.	PUNCT
dti-1373	17	1	we	we	PRON
dti-1373	17	2	found	find	VERB
dti-1373	17	3	that	that	SCONJ
dti-1373	17	4	resveratrol	resveratrol	NOUN
dti-1373	17	5	efficiently	efficiently	ADV
dti-1373	17	6	reversed	reverse	VERB
dti-1373	17	7	the	the	DET
dti-1373	17	8	pma	pma	NOUN
dti-1373	17	9	-	-	PUNCT
dti-1373	17	10	induced	induce	VERB
dti-1373	17	11	mmp-9	mmp-9	NOUN
dti-1373	17	12	secretion	secretion	NOUN
dti-1373	17	13	and	and	CCONJ
dti-1373	17	14	cox-2	cox-2	ADJ
dti-1373	17	15	expression	expression	NOUN
dti-1373	17	16	.	.	PUNCT
dti-1373	18	1	gene	gene	NOUN
dti-1373	18	2	silencing	silencing	NOUN
dti-1373	18	3	of	of	ADP
dti-1373	18	4	sirt1	sirt1	NOUN
dti-1373	18	5	,	,	PUNCT
dti-1373	18	6	a	a	DET
dti-1373	18	7	critical	critical	ADJ
dti-1373	18	8	modulator	modulator	NOUN
dti-1373	18	9	of	of	ADP
dti-1373	18	10	angiogenesis	angiogenesis	NOUN
dti-1373	18	11	and	and	CCONJ
dti-1373	18	12	putative	putative	ADJ
dti-1373	18	13	target	target	NOUN
dti-1373	18	14	of	of	ADP
dti-1373	18	15	resveratrol	resveratrol	NOUN
dti-1373	18	16	,	,	PUNCT
dti-1373	18	17	did	do	AUX
dti-1373	18	18	not	not	PART
dti-1373	18	19	lead	lead	VERB
dti-1373	18	20	to	to	ADP
dti-1373	18	21	significant	significant	ADJ
dti-1373	18	22	reversal	reversal	NOUN
dti-1373	18	23	of	of	ADP
dti-1373	18	24	mmp-9	mmp-9	NUM
dti-1373	18	25	and	and	CCONJ
dti-1373	18	26	cox-2	cox-2	PRON
dti-1373	18	27	inhibition	inhibition	NOUN
dti-1373	18	28	.	.	PUNCT
dti-1373	19	1	decreased	decrease	VERB
dti-1373	19	2	resveratrol	resveratrol	NOUN
dti-1373	19	3	inhibitory	inhibitory	ADJ
dti-1373	19	4	potential	potential	NOUN
dti-1373	19	5	of	of	ADP
dti-1373	19	6	carcinogen	carcinogen	NOUN
dti-1373	19	7	-	-	PUNCT
dti-1373	19	8	induced	induce	VERB
dti-1373	19	9	iκb	iκb	NOUN
dti-1373	19	10	phosphorylation	phosphorylation	NOUN
dti-1373	19	11	in	in	ADP
dti-1373	19	12	sisirt1	sisirt1	NOUN
dti-1373	19	13	-	-	PUNCT
dti-1373	19	14	transfected	transfecte	VERB
dti-1373	19	15	hbmec	hbmec	NOUN
dti-1373	19	16	was	be	AUX
dti-1373	19	17	however	however	ADV
dti-1373	19	18	observed	observe	VERB
dti-1373	19	19	.	.	PUNCT
dti-1373	20	1	our	our	PRON
dti-1373	20	2	results	result	NOUN
dti-1373	20	3	suggest	suggest	VERB
dti-1373	20	4	that	that	SCONJ
dti-1373	20	5	resveratrol	resveratrol	NOUN
dti-1373	20	6	may	may	AUX
dti-1373	20	7	prevent	prevent	VERB
dti-1373	20	8	bbb	bbb	NOUN
dti-1373	20	9	disruption	disruption	NOUN
dti-1373	20	10	during	during	ADP
dti-1373	20	11	neuroinflammation	neuroinflammation	NOUN
dti-1373	20	12	by	by	ADP
dti-1373	20	13	inhibiting	inhibit	VERB
dti-1373	20	14	mmp-9	mmp-9	NOUN
dti-1373	20	15	and	and	CCONJ
dti-1373	20	16	cox-2	cox-2	NOUN
dti-1373	20	17	and	and	CCONJ
dti-1373	20	18	act	act	VERB
dti-1373	20	19	as	as	ADP
dti-1373	20	20	a	a	DET
dti-1373	20	21	pharmacological	pharmacological	ADJ
dti-1373	20	22	nf	nf	ADJ
dti-1373	20	23	-	-	PUNCT
dti-1373	20	24	κb	κb	PROPN
dti-1373	20	25	signal	signal	ADJ
dti-1373	20	26	transduction	transduction	NOUN
dti-1373	20	27	inhibitor	inhibitor	NOUN
dti-1373	20	28	independent	independent	NOUN
dti-1373	20	29	of	of	ADP
dti-1373	20	30	sirt1	sirt1	PROPN
dti-1373	20	31	.	.	PUNCT
dti-1373	21	1	keywords	keyword	NOUN
dti-1373	21	2	:	:	PUNCT
dti-1373	21	3	angiogenesis	angiogenesis	NOUN
dti-1373	21	4	,	,	PUNCT
dti-1373	21	5	inflammation	inflammation	NOUN
dti-1373	21	6	,	,	PUNCT
dti-1373	21	7	resveratrol	resveratrol	NOUN
dti-1373	21	8	,	,	PUNCT
dti-1373	21	9	brain	brain	NOUN
dti-1373	21	10	endothelial	endothelial	ADJ
dti-1373	21	11	cells	cell	NOUN
dti-1373	21	12	,	,	PUNCT
dti-1373	21	13	mmp-9	mmp-9	NOUN
dti-1373	21	14	,	,	PUNCT
dti-1373	21	15	cox-2	cox-2	NOUN
dti-1373	21	16	,	,	PUNCT
dti-1373	21	17	sirt1	sirt1	NOUN
dti-1373	21	18	http://dx.doi.org/10.4137/dti.s9442	http://dx.doi.org/10.4137/dti.s9442	X
dti-1373	21	19	http://www.la-press.com	http://www.la-press.com	X
dti-1373	21	20	http://www.la-press.com	http://www.la-press.com	X
dti-1373	21	21	http://www.la-press.com/drug-target-insights-journal-j23	http://www.la-press.com/drug-target-insights-journal-j23	PROPN
dti-1373	21	22	http://www.la-press.com	http://www.la-press.com	X
dti-1373	22	1	mailto:annabi.borhane@uqam.ca	mailto:annabi.borhane@uqam.ca	PROPN
dti-1373	22	2	annabi	annabi	PROPN
dti-1373	22	3	et	et	PROPN
dti-1373	22	4	al	al	PROPN
dti-1373	22	5	2	2	NUM
dti-1373	22	6	drug	drug	NOUN
dti-1373	22	7	target	target	NOUN
dti-1373	22	8	insights	insight	NOUN
dti-1373	22	9	2012:6	2012:6	ADJ
dti-1373	22	10	introduction	introduction	NOUN
dti-1373	22	11	tumour	tumour	NOUN
dti-1373	22	12	-	-	PUNCT
dti-1373	22	13	associated	associate	VERB
dti-1373	22	14	angiogenesis	angiogenesis	NOUN
dti-1373	22	15	,	,	PUNCT
dti-1373	22	16	a	a	DET
dti-1373	22	17	fundamental	fundamental	ADJ
dti-1373	22	18	process	process	NOUN
dti-1373	22	19	in	in	ADP
dti-1373	22	20	tumour	tumour	NOUN
dti-1373	22	21	growth	growth	NOUN
dti-1373	22	22	and	and	CCONJ
dti-1373	22	23	metastasis	metastasis	NOUN
dti-1373	22	24	,	,	PUNCT
dti-1373	22	25	consists	consist	VERB
dti-1373	22	26	of	of	ADP
dti-1373	22	27	recruiting	recruit	VERB
dti-1373	22	28	ec	ec	NOUN
dti-1373	22	29	toward	toward	ADP
dti-1373	22	30	an	an	DET
dti-1373	22	31	angiogenic	angiogenic	ADJ
dti-1373	22	32	stimulus.1	stimulus.1	NOUN
dti-1373	22	33	the	the	DET
dti-1373	22	34	cells	cell	NOUN
dti-1373	22	35	subsequently	subsequently	ADV
dti-1373	22	36	proliferate	proliferate	VERB
dti-1373	22	37	and	and	CCONJ
dti-1373	22	38	differentiate	differentiate	VERB
dti-1373	22	39	to	to	PART
dti-1373	22	40	form	form	VERB
dti-1373	22	41	endothelial	endothelial	ADJ
dti-1373	22	42	tubes	tube	NOUN
dti-1373	22	43	and	and	CCONJ
dti-1373	22	44	capillary	capillary	ADJ
dti-1373	22	45	-	-	PUNCT
dti-1373	22	46	like	like	ADJ
dti-1373	22	47	structures	structure	NOUN
dti-1373	22	48	in	in	ADP
dti-1373	22	49	order	order	NOUN
dti-1373	22	50	to	to	PART
dti-1373	22	51	deliver	deliver	VERB
dti-1373	22	52	nutrients	nutrient	NOUN
dti-1373	22	53	and	and	CCONJ
dti-1373	22	54	oxygen	oxygen	NOUN
dti-1373	22	55	to	to	ADP
dti-1373	22	56	the	the	DET
dti-1373	22	57	tumour	tumour	NOUN
dti-1373	22	58	and	and	CCONJ
dti-1373	22	59	to	to	PART
dti-1373	22	60	remove	remove	VERB
dti-1373	22	61	the	the	DET
dti-1373	22	62	products	product	NOUN
dti-1373	22	63	of	of	ADP
dti-1373	22	64	its	its	PRON
dti-1373	22	65	metabolism	metabolism	NOUN
dti-1373	22	66	.	.	PUNCT
dti-1373	23	1	in	in	ADP
dti-1373	23	2	recent	recent	ADJ
dti-1373	23	3	years	year	NOUN
dti-1373	23	4	,	,	PUNCT
dti-1373	23	5	several	several	ADJ
dti-1373	23	6	pathways	pathway	NOUN
dti-1373	23	7	have	have	AUX
dti-1373	23	8	,	,	PUNCT
dti-1373	23	9	in	in	ADP
dti-1373	23	10	addition	addition	NOUN
dti-1373	23	11	to	to	ADP
dti-1373	23	12	stimulation	stimulation	NOUN
dti-1373	23	13	of	of	ADP
dti-1373	23	14	tumor	tumor	NOUN
dti-1373	23	15	angiogenesis	angiogenesis	NOUN
dti-1373	23	16	,	,	PUNCT
dti-1373	23	17	been	be	AUX
dti-1373	23	18	suggested	suggest	VERB
dti-1373	23	19	to	to	PART
dti-1373	23	20	contribute	contribute	VERB
dti-1373	23	21	to	to	ADP
dti-1373	23	22	the	the	DET
dti-1373	23	23	cell	cell	NOUN
dti-1373	23	24	metabolic	metabolic	NOUN
dti-1373	23	25	adaptations	adaptation	NOUN
dti-1373	23	26	required	require	VERB
dti-1373	23	27	for	for	ADP
dti-1373	23	28	carcinogenesis	carcinogenesis	NOUN
dti-1373	23	29	,	,	PUNCT
dti-1373	23	30	which	which	PRON
dti-1373	23	31	include	include	VERB
dti-1373	23	32	decreased	decrease	VERB
dti-1373	23	33	tumoural	tumoural	ADJ
dti-1373	23	34	apoptosis	apoptosis	NOUN
dti-1373	23	35	,	,	PUNCT
dti-1373	23	36	increased	increase	VERB
dti-1373	23	37	invasion	invasion	NOUN
dti-1373	23	38	and	and	CCONJ
dti-1373	23	39	metastasis	metastasis	NOUN
dti-1373	23	40	,	,	PUNCT
dti-1373	23	41	immune	immune	ADJ
dti-1373	23	42	suppression	suppression	NOUN
dti-1373	23	43	and	and	CCONJ
dti-1373	23	44	tumourassociated	tumourassociate	VERB
dti-1373	23	45	inflammation.2,3	inflammation.2,3	PRON
dti-1373	23	46	an	an	DET
dti-1373	23	47	interesting	interesting	ADJ
dti-1373	23	48	link	link	NOUN
dti-1373	23	49	between	between	ADP
dti-1373	23	50	overexpression	overexpression	NOUN
dti-1373	23	51	of	of	ADP
dti-1373	23	52	pro	pro	ADJ
dti-1373	23	53	-	-	ADJ
dti-1373	23	54	inflammatory	inflammatory	ADJ
dti-1373	23	55	markers	marker	NOUN
dti-1373	23	56	such	such	ADJ
dti-1373	23	57	as	as	ADP
dti-1373	23	58	matrix	matrix	NOUN
dti-1373	23	59	metalloproteinase-9	metalloproteinase-9	NUM
dti-1373	23	60	(	(	PUNCT
dti-1373	23	61	mmp-9	mmp-9	NUM
dti-1373	23	62	)	)	PUNCT
dti-1373	23	63	and	and	CCONJ
dti-1373	23	64	cyclooxygenase	cyclooxygenase	NOUN
dti-1373	23	65	(	(	PUNCT
dti-1373	23	66	cox)-2	cox)-2	PROPN
dti-1373	23	67	,	,	PUNCT
dti-1373	23	68	and	and	CCONJ
dti-1373	23	69	tumour	tumour	PRON
dti-1373	23	70	angiogenesis	angiogenesis	NOUN
dti-1373	23	71	was	be	AUX
dti-1373	23	72	recently	recently	ADV
dti-1373	23	73	described	describe	VERB
dti-1373	23	74	as	as	ADP
dti-1373	23	75	one	one	NUM
dti-1373	23	76	such	such	ADJ
dti-1373	23	77	metabolic	metabolic	NOUN
dti-1373	23	78	adaptative	adaptative	ADJ
dti-1373	23	79	phenotype.4–6	phenotype.4–6	NOUN
dti-1373	23	80	while	while	SCONJ
dti-1373	23	81	flavonoids	flavonoid	NOUN
dti-1373	23	82	and	and	CCONJ
dti-1373	23	83	related	relate	VERB
dti-1373	23	84	polyphenolic	polyphenolic	ADJ
dti-1373	23	85	compounds	compound	NOUN
dti-1373	23	86	,	,	PUNCT
dti-1373	23	87	such	such	ADJ
dti-1373	23	88	as	as	ADP
dti-1373	23	89	resveratrol	resveratrol	NOUN
dti-1373	23	90	,	,	PUNCT
dti-1373	23	91	have	have	AUX
dti-1373	23	92	demonstrated	demonstrate	VERB
dti-1373	23	93	significant	significant	ADJ
dti-1373	23	94	antiinflammatory	antiinflammatory	NOUN
dti-1373	23	95	activity	activity	NOUN
dti-1373	23	96	,	,	PUNCT
dti-1373	23	97	predominantly	predominantly	ADV
dti-1373	23	98	,	,	PUNCT
dti-1373	23	99	through	through	ADP
dti-1373	23	100	the	the	DET
dti-1373	23	101	inhibition	inhibition	NOUN
dti-1373	23	102	of	of	ADP
dti-1373	23	103	nf	nf	ADJ
dti-1373	23	104	-	-	PUNCT
dti-1373	23	105	κb	κb	NOUN
dti-1373	23	106	signaling,7	signaling,7	NOUN
dti-1373	23	107	their	their	PRON
dti-1373	23	108	potential	potential	ADJ
dti-1373	23	109	therapeutic	therapeutic	ADJ
dti-1373	23	110	application	application	NOUN
dti-1373	23	111	upon	upon	SCONJ
dti-1373	23	112	the	the	DET
dti-1373	23	113	cerebral	cerebral	ADJ
dti-1373	23	114	vascular	vascular	ADJ
dti-1373	23	115	compartment	compartment	NOUN
dti-1373	23	116	in	in	ADP
dti-1373	23	117	neuroinflammation	neuroinflammation	NOUN
dti-1373	23	118	still	still	ADV
dti-1373	23	119	remains	remains	AUX
dti-1373	23	120	poorly	poorly	ADV
dti-1373	23	121	documented	document	VERB
dti-1373	23	122	.	.	PUNCT
dti-1373	24	1	while	while	SCONJ
dti-1373	24	2	human	human	ADJ
dti-1373	24	3	brain	brain	NOUN
dti-1373	24	4	microvascular	microvascular	NOUN
dti-1373	24	5	endothelial	endothelial	ADJ
dti-1373	24	6	cells	cell	NOUN
dti-1373	24	7	(	(	PUNCT
dti-1373	24	8	hbmec	hbmec	NOUN
dti-1373	24	9	)	)	PUNCT
dti-1373	24	10	play	play	VERB
dti-1373	24	11	an	an	DET
dti-1373	24	12	essential	essential	ADJ
dti-1373	24	13	role	role	NOUN
dti-1373	24	14	as	as	ADP
dti-1373	24	15	structural	structural	ADJ
dti-1373	24	16	and	and	CCONJ
dti-1373	24	17	functional	functional	ADJ
dti-1373	24	18	components	component	NOUN
dti-1373	24	19	of	of	ADP
dti-1373	24	20	the	the	DET
dti-1373	24	21	blood	blood	NOUN
dti-1373	24	22	-	-	PUNCT
dti-1373	24	23	brain	brain	NOUN
dti-1373	24	24	barrier	barrier	NOUN
dti-1373	24	25	(	(	PUNCT
dti-1373	24	26	bbb	bbb	PROPN
dti-1373	24	27	)	)	PUNCT
dti-1373	24	28	,	,	PUNCT
dti-1373	24	29	its	its	PRON
dti-1373	24	30	disruption	disruption	NOUN
dti-1373	24	31	by	by	ADP
dti-1373	24	32	mmp-9	mmp-9	NOUN
dti-1373	24	33	is	be	AUX
dti-1373	24	34	believed	believe	VERB
dti-1373	24	35	to	to	PART
dti-1373	24	36	favor	favor	VERB
dti-1373	24	37	tumor	tumor	NOUN
dti-1373	24	38	invasion.8,9	invasion.8,9	PRON
dti-1373	24	39	recent	recent	ADJ
dti-1373	24	40	studies	study	NOUN
dti-1373	24	41	in	in	ADP
dti-1373	24	42	fact	fact	NOUN
dti-1373	24	43	delineated	delineate	VERB
dti-1373	24	44	a	a	DET
dti-1373	24	45	unique	unique	ADJ
dti-1373	24	46	brain	brain	NOUN
dti-1373	24	47	endothelial	endothelial	ADJ
dti-1373	24	48	phenotype	phenotype	NOUN
dti-1373	24	49	in	in	ADP
dti-1373	24	50	which	which	PRON
dti-1373	24	51	mmp-9	mmp-9	VERB
dti-1373	24	52	secretion	secretion	NOUN
dti-1373	24	53	by	by	ADP
dti-1373	24	54	hbmec	hbmec	NOUN
dti-1373	24	55	was	be	AUX
dti-1373	24	56	increased	increase	VERB
dti-1373	24	57	upon	upon	SCONJ
dti-1373	24	58	treatment	treatment	NOUN
dti-1373	24	59	with	with	ADP
dti-1373	24	60	the	the	DET
dti-1373	24	61	tumor	tumor	NOUN
dti-1373	24	62	-	-	PUNCT
dti-1373	24	63	promoting	promote	VERB
dti-1373	24	64	agent	agent	NOUN
dti-1373	24	65	phorbol	phorbol	NOUN
dti-1373	24	66	12	12	NUM
dti-1373	24	67	-	-	PUNCT
dti-1373	24	68	myristate	myristate	ADJ
dti-1373	24	69	13	13	NUM
dti-1373	24	70	-	-	PUNCT
dti-1373	24	71	acetate	acetate	NOUN
dti-1373	24	72	(	(	PUNCT
dti-1373	24	73	pma).10,11	pma).10,11	NOUN
dti-1373	24	74	inhibition	inhibition	NOUN
dti-1373	24	75	of	of	ADP
dti-1373	24	76	mmp-9	mmp-9	NOUN
dti-1373	24	77	secretion	secretion	NOUN
dti-1373	24	78	was	be	AUX
dti-1373	24	79	demonstrated	demonstrate	VERB
dti-1373	24	80	to	to	PART
dti-1373	24	81	reduce	reduce	VERB
dti-1373	24	82	both	both	PRON
dti-1373	24	83	in	in	ADP
dti-1373	24	84	vitro	vitro	X
dti-1373	24	85	invasion	invasion	NOUN
dti-1373	24	86	and	and	CCONJ
dti-1373	24	87	angiogenesis	angiogenesis	NOUN
dti-1373	24	88	in	in	ADP
dti-1373	24	89	human	human	ADJ
dti-1373	24	90	microvascular	microvascular	NOUN
dti-1373	24	91	ec.12	ec.12	NOUN
dti-1373	24	92	among	among	ADP
dti-1373	24	93	the	the	DET
dti-1373	24	94	signalling	signal	VERB
dti-1373	24	95	pathways	pathway	NOUN
dti-1373	24	96	involved	involve	VERB
dti-1373	24	97	,	,	PUNCT
dti-1373	24	98	nf	nf	ADJ
dti-1373	24	99	-	-	PUNCT
dti-1373	24	100	κb	κb	ADJ
dti-1373	24	101	signalling	signalling	NOUN
dti-1373	24	102	was	be	AUX
dti-1373	24	103	the	the	DET
dti-1373	24	104	one	one	NOUN
dti-1373	24	105	that	that	PRON
dti-1373	24	106	enabled	enable	VERB
dti-1373	24	107	the	the	DET
dti-1373	24	108	joint	joint	ADJ
dti-1373	24	109	control	control	NOUN
dti-1373	24	110	of	of	ADP
dti-1373	24	111	both	both	PRON
dti-1373	24	112	mmp-9	mmp-9	ADJ
dti-1373	24	113	and	and	CCONJ
dti-1373	24	114	cox-2	cox-2	ADJ
dti-1373	24	115	inflammation	inflammation	NOUN
dti-1373	24	116	marker	marker	NOUN
dti-1373	24	117	expression.13,14	expression.13,14	ADV
dti-1373	24	118	recent	recent	ADJ
dti-1373	24	119	studies	study	NOUN
dti-1373	24	120	point	point	VERB
dti-1373	24	121	to	to	ADP
dti-1373	24	122	sirt1	sirt1	NOUN
dti-1373	24	123	,	,	PUNCT
dti-1373	24	124	the	the	DET
dti-1373	24	125	most	most	ADV
dti-1373	24	126	widely	widely	ADV
dti-1373	24	127	investigated	investigate	VERB
dti-1373	24	128	and	and	CCONJ
dti-1373	24	129	best	well	ADV
dti-1373	24	130	known	know	VERB
dti-1373	24	131	sirtuin	sirtuin	NOUN
dti-1373	24	132	,	,	PUNCT
dti-1373	24	133	as	as	ADP
dti-1373	24	134	a	a	DET
dti-1373	24	135	key	key	ADJ
dti-1373	24	136	regulator	regulator	NOUN
dti-1373	24	137	of	of	ADP
dti-1373	24	138	vascular	vascular	ADJ
dti-1373	24	139	endothelial	endothelial	NOUN
dti-1373	24	140	homeostasis	homeostasis	NOUN
dti-1373	24	141	controlling	control	VERB
dti-1373	24	142	angiogenesis	angiogenesis	NOUN
dti-1373	24	143	,	,	PUNCT
dti-1373	24	144	vascular	vascular	ADJ
dti-1373	24	145	tone	tone	NOUN
dti-1373	24	146	and	and	CCONJ
dti-1373	24	147	endothelial	endothelial	ADJ
dti-1373	24	148	dysfunction.15	dysfunction.15	NOUN
dti-1373	24	149	sirtuins	sirtuin	NOUN
dti-1373	24	150	are	be	AUX
dti-1373	24	151	a	a	DET
dti-1373	24	152	family	family	NOUN
dti-1373	24	153	of	of	ADP
dti-1373	24	154	conserved	conserved	ADJ
dti-1373	24	155	proteins	protein	NOUN
dti-1373	24	156	with	with	ADP
dti-1373	24	157	deacetylase	deacetylase	PROPN
dti-1373	24	158	and	and	CCONJ
dti-1373	24	159	adp	adp	PROPN
dti-1373	24	160	-	-	PUNCT
dti-1373	24	161	ribosyltransferase	ribosyltransferase	NOUN
dti-1373	24	162	activity	activity	NOUN
dti-1373	24	163	encoded	encode	VERB
dti-1373	24	164	in	in	ADP
dti-1373	24	165	humans	human	NOUN
dti-1373	24	166	by	by	ADP
dti-1373	24	167	seven	seven	NUM
dti-1373	24	168	genes	gene	NOUN
dti-1373	24	169	(	(	PUNCT
dti-1373	24	170	sirt1	sirt1	NOUN
dti-1373	24	171	-	-	NOUN
dti-1373	24	172	7).16	7).16	PROPN
dti-1373	24	173	in	in	ADP
dti-1373	24	174	cancer	cancer	NOUN
dti-1373	24	175	cells	cell	NOUN
dti-1373	24	176	,	,	PUNCT
dti-1373	24	177	conflicting	conflicting	ADJ
dti-1373	24	178	reports	report	NOUN
dti-1373	24	179	regarding	regard	VERB
dti-1373	24	180	the	the	DET
dti-1373	24	181	expression	expression	NOUN
dti-1373	24	182	of	of	ADP
dti-1373	24	183	sirt1	sirt1	NOUN
dti-1373	24	184	show	show	NOUN
dti-1373	24	185	either	either	CCONJ
dti-1373	24	186	up	up	ADP
dti-1373	24	187	-	-	PUNCT
dti-1373	24	188	regulation17,18	regulation17,18	NOUN
dti-1373	24	189	or	or	CCONJ
dti-1373	24	190	downregulation19	downregulation19	NOUN
dti-1373	24	191	of	of	ADP
dti-1373	24	192	sirt1	sirt1	PROPN
dti-1373	24	193	.	.	PUNCT
dti-1373	24	194	sirt1	sirt1	PROPN
dti-1373	24	195	may	may	AUX
dti-1373	24	196	thus	thus	ADV
dti-1373	24	197	play	play	VERB
dti-1373	24	198	a	a	DET
dti-1373	24	199	critical	critical	ADJ
dti-1373	24	200	role	role	NOUN
dti-1373	24	201	in	in	ADP
dti-1373	24	202	tumor	tumor	NOUN
dti-1373	24	203	progression	progression	NOUN
dti-1373	24	204	,	,	PUNCT
dti-1373	24	205	and	and	CCONJ
dti-1373	24	206	drug	drug	NOUN
dti-1373	24	207	resistance	resistance	NOUN
dti-1373	24	208	.	.	PUNCT
dti-1373	25	1	while	while	SCONJ
dti-1373	25	2	sirt1	sirt1	NOUN
dti-1373	25	3	inhibitors	inhibitor	NOUN
dti-1373	25	4	have	have	AUX
dti-1373	25	5	shown	show	VERB
dti-1373	25	6	promising	promising	ADJ
dti-1373	25	7	anticancer	anticancer	NOUN
dti-1373	25	8	effects	effect	NOUN
dti-1373	25	9	in	in	ADP
dti-1373	25	10	animal	animal	NOUN
dti-1373	25	11	models	model	NOUN
dti-1373	25	12	of	of	ADP
dti-1373	25	13	cancer	cancer	NOUN
dti-1373	25	14	,	,	PUNCT
dti-1373	25	15	its	its	PRON
dti-1373	25	16	implication	implication	NOUN
dti-1373	25	17	in	in	ADP
dti-1373	25	18	a	a	DET
dti-1373	25	19	brain	brain	NOUN
dti-1373	25	20	ec	ec	PROPN
dti-1373	25	21	model	model	NOUN
dti-1373	25	22	has	have	VERB
dti-1373	25	23	yet	yet	ADV
dti-1373	25	24	to	to	PART
dti-1373	25	25	be	be	AUX
dti-1373	25	26	documented	document	VERB
dti-1373	25	27	.	.	PUNCT
dti-1373	26	1	more	more	ADV
dti-1373	26	2	importantly	importantly	ADV
dti-1373	26	3	,	,	PUNCT
dti-1373	26	4	the	the	DET
dti-1373	26	5	expression	expression	NOUN
dti-1373	26	6	of	of	ADP
dti-1373	26	7	sirt1	sirt1	NOUN
dti-1373	26	8	in	in	ADP
dti-1373	26	9	the	the	DET
dti-1373	26	10	brain	brain	NOUN
dti-1373	26	11	ec	ec	PROPN
dti-1373	26	12	compartment	compartment	NOUN
dti-1373	26	13	as	as	ADV
dti-1373	26	14	well	well	ADV
dti-1373	26	15	as	as	ADP
dti-1373	26	16	impact	impact	NOUN
dti-1373	26	17	of	of	ADP
dti-1373	26	18	its	its	PRON
dti-1373	26	19	pharmacological	pharmacological	NOUN
dti-1373	26	20	targeting	targeting	NOUN
dti-1373	26	21	is	be	AUX
dti-1373	26	22	still	still	ADV
dti-1373	26	23	unknown	unknown	ADJ
dti-1373	26	24	.	.	PUNCT
dti-1373	27	1	given	give	VERB
dti-1373	27	2	that	that	SCONJ
dti-1373	27	3	sirt1	sirt1	ADJ
dti-1373	27	4	-	-	ADJ
dti-1373	27	5	independent	independent	ADJ
dti-1373	27	6	mechanisms	mechanism	NOUN
dti-1373	27	7	were	be	AUX
dti-1373	27	8	recently	recently	ADV
dti-1373	27	9	reported	report	VERB
dti-1373	27	10	in	in	ADP
dti-1373	27	11	the	the	DET
dti-1373	27	12	action	action	NOUN
dti-1373	27	13	of	of	ADP
dti-1373	27	14	resveratrol,20	resveratrol,20	NOUN
dti-1373	27	15	this	this	DET
dti-1373	27	16	current	current	ADJ
dti-1373	27	17	study	study	NOUN
dti-1373	27	18	therefore	therefore	ADV
dti-1373	27	19	focuses	focus	VERB
dti-1373	27	20	on	on	ADP
dti-1373	27	21	resveratrol	resveratrol	NOUN
dti-1373	27	22	as	as	ADP
dti-1373	27	23	a	a	DET
dti-1373	27	24	potential	potential	ADJ
dti-1373	27	25	signal	signal	NOUN
dti-1373	27	26	transduction	transduction	NOUN
dti-1373	27	27	inhibitor	inhibitor	NOUN
dti-1373	27	28	of	of	ADP
dti-1373	27	29	carcinogen	carcinogen	NOUN
dti-1373	27	30	-	-	PUNCT
dti-1373	27	31	mediated	mediate	VERB
dti-1373	27	32	induction	induction	NOUN
dti-1373	27	33	of	of	ADP
dti-1373	27	34	the	the	DET
dti-1373	27	35	nf	nf	ADJ
dti-1373	27	36	-	-	PUNCT
dti-1373	27	37	κb	κb	NOUN
dti-1373	27	38	pathway	pathway	NOUN
dti-1373	27	39	in	in	ADP
dti-1373	27	40	a	a	DET
dti-1373	27	41	human	human	ADJ
dti-1373	27	42	brain	brain	NOUN
dti-1373	27	43	ec	ec	PROPN
dti-1373	27	44	model	model	NOUN
dti-1373	27	45	and	and	CCONJ
dti-1373	27	46	questions	question	NOUN
dti-1373	27	47	the	the	DET
dti-1373	27	48	involvement	involvement	NOUN
dti-1373	27	49	of	of	ADP
dti-1373	27	50	sirt1	sirt1	PROPN
dti-1373	27	51	.	.	PUNCT
dti-1373	27	52	materials	material	NOUN
dti-1373	27	53	and	and	CCONJ
dti-1373	27	54	methods	method	NOUN
dti-1373	27	55	reagents	reagent	NOUN
dti-1373	27	56	and	and	CCONJ
dti-1373	27	57	cell	cell	NOUN
dti-1373	27	58	culture	culture	NOUN
dti-1373	27	59	bovine	bovine	PROPN
dti-1373	27	60	serum	serum	NOUN
dti-1373	27	61	albumin	albumin	PROPN
dti-1373	27	62	(	(	PUNCT
dti-1373	27	63	bsa	bsa	PROPN
dti-1373	27	64	)	)	PUNCT
dti-1373	27	65	was	be	AUX
dti-1373	27	66	purchased	purchase	VERB
dti-1373	27	67	from	from	ADP
dti-1373	27	68	myclone	myclone	PROPN
dti-1373	27	69	laboratories	laboratory	NOUN
dti-1373	27	70	(	(	PUNCT
dti-1373	27	71	logan	logan	PROPN
dti-1373	27	72	,	,	PUNCT
dti-1373	27	73	ut	ut	PROPN
dti-1373	27	74	)	)	PUNCT
dti-1373	27	75	.	.	PUNCT
dti-1373	28	1	electrophoresis	electrophoresis	NOUN
dti-1373	28	2	reagents	reagent	NOUN
dti-1373	28	3	were	be	AUX
dti-1373	28	4	purchased	purchase	VERB
dti-1373	28	5	from	from	ADP
dti-1373	28	6	bio	bio	PROPN
dti-1373	28	7	-	-	PROPN
dti-1373	28	8	rad	rad	PROPN
dti-1373	28	9	(	(	PUNCT
dti-1373	28	10	mississauga	mississauga	PROPN
dti-1373	28	11	,	,	PUNCT
dti-1373	28	12	on	on	ADP
dti-1373	28	13	)	)	PUNCT
dti-1373	28	14	.	.	PUNCT
dti-1373	29	1	the	the	DET
dti-1373	29	2	enhanced	enhanced	ADJ
dti-1373	29	3	chemiluminescence	chemiluminescence	NOUN
dti-1373	29	4	(	(	PUNCT
dti-1373	29	5	ecl	ecl	NOUN
dti-1373	29	6	)	)	PUNCT
dti-1373	29	7	reagents	reagent	NOUN
dti-1373	29	8	were	be	AUX
dti-1373	29	9	from	from	ADP
dti-1373	29	10	perkin	perkin	PROPN
dti-1373	29	11	elmer	elmer	PROPN
dti-1373	29	12	(	(	PUNCT
dti-1373	29	13	waltham	waltham	PROPN
dti-1373	29	14	,	,	PUNCT
dti-1373	29	15	ma	ma	PROPN
dti-1373	29	16	)	)	PUNCT
dti-1373	29	17	.	.	PUNCT
dti-1373	30	1	micro	micro	PROPN
dti-1373	30	2	bicinchoninic	bicinchoninic	ADJ
dti-1373	30	3	acid	acid	NOUN
dti-1373	30	4	protein	protein	NOUN
dti-1373	30	5	assay	assay	NOUN
dti-1373	30	6	reagents	reagent	NOUN
dti-1373	30	7	were	be	AUX
dti-1373	30	8	from	from	ADP
dti-1373	30	9	pierce	pierce	PROPN
dti-1373	30	10	(	(	PUNCT
dti-1373	30	11	rockford	rockford	PROPN
dti-1373	30	12	,	,	PUNCT
dti-1373	30	13	il	il	PROPN
dti-1373	30	14	)	)	PUNCT
dti-1373	30	15	.	.	PUNCT
dti-1373	31	1	the	the	DET
dti-1373	31	2	polyclonal	polyclonal	ADJ
dti-1373	31	3	antibodies	antibodie	VERB
dti-1373	31	4	against	against	ADP
dti-1373	31	5	iκb	iκb	NOUN
dti-1373	31	6	and	and	CCONJ
dti-1373	31	7	phospho	phospho	NOUN
dti-1373	31	8	-	-	PUNCT
dti-1373	31	9	iκb	iκb	NOUN
dti-1373	31	10	were	be	AUX
dti-1373	31	11	purchased	purchase	VERB
dti-1373	31	12	from	from	ADP
dti-1373	31	13	cell	cell	NOUN
dti-1373	31	14	signaling	signal	VERB
dti-1373	31	15	(	(	PUNCT
dti-1373	31	16	danvers	danver	NOUN
dti-1373	31	17	,	,	PUNCT
dti-1373	31	18	ma	ma	PROPN
dti-1373	31	19	)	)	PUNCT
dti-1373	31	20	.	.	PUNCT
dti-1373	32	1	the	the	DET
dti-1373	32	2	monoclonal	monoclonal	NOUN
dti-1373	32	3	antibody	antibody	NOUN
dti-1373	32	4	against	against	ADP
dti-1373	32	5	gapdh	gapdh	NOUN
dti-1373	32	6	was	be	AUX
dti-1373	32	7	from	from	ADP
dti-1373	32	8	advanced	advanced	PROPN
dti-1373	32	9	immunochemical	immunochemical	PROPN
dti-1373	32	10	inc	inc	PROPN
dti-1373	32	11	.	.	PUNCT
dti-1373	33	1	(	(	PUNCT
dti-1373	33	2	long	long	ADJ
dti-1373	33	3	beach	beach	NOUN
dti-1373	33	4	,	,	PUNCT
dti-1373	33	5	ca	ca	NOUN
dti-1373	33	6	)	)	PUNCT
dti-1373	33	7	.	.	PUNCT
dti-1373	34	1	horseradish	horseradish	ADJ
dti-1373	34	2	peroxidase	peroxidase	NOUN
dti-1373	34	3	-	-	PUNCT
dti-1373	34	4	conjugated	conjugate	VERB
dti-1373	34	5	donkey	donkey	NOUN
dti-1373	34	6	anti	anti	ADJ
dti-1373	34	7	-	-	NOUN
dti-1373	34	8	rabbit	rabbit	ADJ
dti-1373	34	9	and	and	CCONJ
dti-1373	34	10	anti	anti	ADJ
dti-1373	34	11	-	-	ADJ
dti-1373	34	12	mouse	mouse	ADJ
dti-1373	34	13	igg	igg	PROPN
dti-1373	34	14	secondary	secondary	ADJ
dti-1373	34	15	antibodies	antibody	NOUN
dti-1373	34	16	were	be	AUX
dti-1373	34	17	from	from	ADP
dti-1373	34	18	jackson	jackson	PROPN
dti-1373	34	19	immunoresearch	immunoresearch	PROPN
dti-1373	34	20	laboratories	laboratory	NOUN
dti-1373	34	21	(	(	PUNCT
dti-1373	34	22	west	west	PROPN
dti-1373	34	23	grove	grove	PROPN
dti-1373	34	24	,	,	PUNCT
dti-1373	34	25	pa	pa	PROPN
dti-1373	34	26	)	)	PUNCT
dti-1373	34	27	.	.	PUNCT
dti-1373	35	1	sodium	sodium	NOUN
dti-1373	35	2	dodecylsulfate	dodecylsulfate	VERB
dti-1373	35	3	(	(	PUNCT
dti-1373	35	4	sds	sds	PROPN
dti-1373	35	5	)	)	PUNCT
dti-1373	35	6	and	and	CCONJ
dti-1373	35	7	all	all	DET
dti-1373	35	8	other	other	ADJ
dti-1373	35	9	reagents	reagent	NOUN
dti-1373	35	10	were	be	AUX
dti-1373	35	11	from	from	ADP
dti-1373	35	12	sigma	sigma	PROPN
dti-1373	35	13	-	-	PUNCT
dti-1373	35	14	aldrich	aldrich	PROPN
dti-1373	35	15	canada	canada	PROPN
dti-1373	35	16	.	.	PUNCT
dti-1373	36	1	human	human	ADJ
dti-1373	36	2	brain	brain	NOUN
dti-1373	36	3	microvascular	microvascular	NOUN
dti-1373	36	4	endothelial	endothelial	ADJ
dti-1373	36	5	cells	cell	NOUN
dti-1373	36	6	(	(	PUNCT
dti-1373	36	7	hbmec	hbmec	PROPN
dti-1373	36	8	)	)	PUNCT
dti-1373	36	9	were	be	AUX
dti-1373	36	10	characterized	characterize	VERB
dti-1373	36	11	and	and	CCONJ
dti-1373	36	12	generously	generously	ADV
dti-1373	36	13	provided	provide	VERB
dti-1373	36	14	by	by	ADP
dti-1373	36	15	dr	dr	PROPN
dti-1373	36	16	.	.	PROPN
dti-1373	36	17	kwang	kwang	PROPN
dti-1373	36	18	sik	sik	PROPN
dti-1373	36	19	kim	kim	PROPN
dti-1373	36	20	of	of	ADP
dti-1373	36	21	the	the	DET
dti-1373	36	22	johns	johns	PROPN
dti-1373	36	23	hopkins	hopkins	PROPN
dti-1373	36	24	university	university	PROPN
dti-1373	36	25	school	school	NOUN
dti-1373	36	26	of	of	ADP
dti-1373	36	27	medicine	medicine	NOUN
dti-1373	36	28	(	(	PUNCT
dti-1373	36	29	baltimore	baltimore	PROPN
dti-1373	36	30	,	,	PUNCT
dti-1373	36	31	md).21,22	md).21,22	PROPN
dti-1373	36	32	cells	cell	NOUN
dti-1373	36	33	were	be	AUX
dti-1373	36	34	cultured	cultured	ADJ
dti-1373	36	35	at	at	ADP
dti-1373	36	36	37	37	NUM
dti-1373	36	37	°	°	NOUN
dti-1373	36	38	c	c	NOUN
dti-1373	36	39	under	under	ADP
dti-1373	36	40	a	a	DET
dti-1373	36	41	humidified	humidify	VERB
dti-1373	36	42	atmosphere	atmosphere	NOUN
dti-1373	36	43	containing	contain	VERB
dti-1373	36	44	5	5	NUM
dti-1373	36	45	%	%	NOUN
dti-1373	36	46	co2	co2	NOUN
dti-1373	36	47	.	.	PUNCT
dti-1373	37	1	all	all	DET
dti-1373	37	2	experiments	experiment	NOUN
dti-1373	37	3	were	be	AUX
dti-1373	37	4	performed	perform	VERB
dti-1373	37	5	using	use	VERB
dti-1373	37	6	passages	passage	NOUN
dti-1373	37	7	3	3	NUM
dti-1373	37	8	to	to	PART
dti-1373	37	9	28	28	NUM
dti-1373	37	10	.	.	PUNCT
dti-1373	38	1	gelatin	gelatin	NOUN
dti-1373	38	2	zymography	zymography	PROPN
dti-1373	38	3	and	and	CCONJ
dti-1373	38	4	immunoblotting	immunoblotte	VERB
dti-1373	38	5	procedures	procedure	NOUN
dti-1373	38	6	proteins	protein	NOUN
dti-1373	38	7	from	from	ADP
dti-1373	38	8	control	control	NOUN
dti-1373	38	9	and	and	CCONJ
dti-1373	38	10	treated	treat	VERB
dti-1373	38	11	cells	cell	NOUN
dti-1373	38	12	were	be	AUX
dti-1373	38	13	separated	separate	VERB
dti-1373	38	14	by	by	ADP
dti-1373	38	15	sds	sds	PROPN
dti-1373	38	16	-	-	PUNCT
dti-1373	38	17	page	page	NOUN
dti-1373	38	18	,	,	PUNCT
dti-1373	38	19	and	and	CCONJ
dti-1373	38	20	electrotransferred	electrotransferre	VERB
dti-1373	38	21	to	to	ADP
dti-1373	38	22	polyvinylidene	polyvinylidene	NOUN
dti-1373	38	23	difluoride	difluoride	NOUN
dti-1373	38	24	membranes	membrane	NOUN
dti-1373	38	25	as	as	SCONJ
dti-1373	38	26	previously	previously	ADV
dti-1373	38	27	described.21	described.21	NOUN
dti-1373	38	28	gelatin	gelatin	NOUN
dti-1373	38	29	zymography	zymography	PROPN
dti-1373	38	30	was	be	AUX
dti-1373	38	31	used	use	VERB
dti-1373	38	32	to	to	PART
dti-1373	38	33	assess	assess	VERB
dti-1373	38	34	the	the	DET
dti-1373	38	35	extent	extent	NOUN
dti-1373	38	36	of	of	ADP
dti-1373	38	37	http://www.la-press.com	http://www.la-press.com	X
dti-1373	38	38	sirt1	sirt1	NOUN
dti-1373	38	39	expression	expression	NOUN
dti-1373	38	40	in	in	ADP
dti-1373	38	41	inflammatory	inflammatory	ADJ
dti-1373	38	42	cerebral	cerebral	ADJ
dti-1373	38	43	endothelium	endothelium	NOUN
dti-1373	38	44	drug	drug	NOUN
dti-1373	38	45	target	target	NOUN
dti-1373	38	46	insights	insight	NOUN
dti-1373	38	47	2012:6	2012:6	NUM
dti-1373	38	48	3	3	NUM
dti-1373	38	49	prommp-9	prommp-9	NUM
dti-1373	38	50	activity	activity	NOUN
dti-1373	38	51	as	as	ADP
dti-1373	38	52	previously	previously	ADV
dti-1373	38	53	described.23	described.23	VERB
dti-1373	38	54	briefly	briefly	ADV
dti-1373	38	55	,	,	PUNCT
dti-1373	38	56	an	an	DET
dti-1373	38	57	aliquot	aliquot	NOUN
dti-1373	38	58	(	(	PUNCT
dti-1373	38	59	20	20	NUM
dti-1373	38	60	µl	µl	NOUN
dti-1373	38	61	)	)	PUNCT
dti-1373	38	62	of	of	ADP
dti-1373	38	63	the	the	DET
dti-1373	38	64	culture	culture	NOUN
dti-1373	38	65	medium	medium	NOUN
dti-1373	38	66	was	be	AUX
dti-1373	38	67	subjected	subject	VERB
dti-1373	38	68	to	to	ADP
dti-1373	38	69	sds	sds	NOUN
dti-1373	38	70	-	-	PUNCT
dti-1373	38	71	page	page	NOUN
dti-1373	38	72	in	in	ADP
dti-1373	38	73	a	a	DET
dti-1373	38	74	gel	gel	NOUN
dti-1373	38	75	containing	contain	VERB
dti-1373	38	76	0.1	0.1	NUM
dti-1373	38	77	mg	mg	NUM
dti-1373	38	78	/	/	SYM
dti-1373	38	79	ml	ml	NOUN
dti-1373	38	80	gelatin	gelatin	NOUN
dti-1373	38	81	.	.	PUNCT
dti-1373	39	1	the	the	DET
dti-1373	39	2	gels	gel	NOUN
dti-1373	39	3	were	be	AUX
dti-1373	39	4	then	then	ADV
dti-1373	39	5	incubated	incubate	VERB
dti-1373	39	6	in	in	ADP
dti-1373	39	7	2.5	2.5	NUM
dti-1373	39	8	%	%	NOUN
dti-1373	39	9	triton	triton	PROPN
dti-1373	39	10	x-100	x-100	PROPN
dti-1373	39	11	and	and	CCONJ
dti-1373	39	12	rinsed	rinse	VERB
dti-1373	39	13	in	in	ADP
dti-1373	39	14	nanopure	nanopure	NOUN
dti-1373	39	15	distilled	distil	VERB
dti-1373	39	16	h2o	h2o	PROPN
dti-1373	39	17	.	.	PUNCT
dti-1373	40	1	gels	gel	NOUN
dti-1373	40	2	were	be	AUX
dti-1373	40	3	further	far	ADV
dti-1373	40	4	incubated	incubate	VERB
dti-1373	40	5	at	at	ADP
dti-1373	40	6	37	37	NUM
dti-1373	40	7	°	°	NOUN
dti-1373	40	8	c	c	NOUN
dti-1373	40	9	for	for	ADP
dti-1373	40	10	20	20	NUM
dti-1373	40	11	hrs	hrs	NOUN
dti-1373	40	12	in	in	ADP
dti-1373	40	13	20	20	NUM
dti-1373	40	14	mm	mm	NOUN
dti-1373	40	15	nacl	nacl	NOUN
dti-1373	40	16	,	,	PUNCT
dti-1373	40	17	5	5	NUM
dti-1373	40	18	mm	mm	NOUN
dti-1373	40	19	cacl2	cacl2	NOUN
dti-1373	40	20	,	,	PUNCT
dti-1373	40	21	0.02	0.02	NUM
dti-1373	40	22	%	%	NOUN
dti-1373	40	23	brij-35	brij-35	NOUN
dti-1373	40	24	,	,	PUNCT
dti-1373	40	25	50	50	NUM
dti-1373	40	26	mm	mm	NUM
dti-1373	40	27	tris	tris	ADJ
dti-1373	40	28	-	-	PUNCT
dti-1373	40	29	hcl	hcl	NOUN
dti-1373	40	30	buffer	buffer	NOUN
dti-1373	40	31	,	,	PUNCT
dti-1373	40	32	ph	ph	NOUN
dti-1373	40	33	7.6	7.6	NUM
dti-1373	40	34	,	,	PUNCT
dti-1373	40	35	then	then	ADV
dti-1373	40	36	stained	stain	VERB
dti-1373	40	37	with	with	ADP
dti-1373	40	38	0.1	0.1	NUM
dti-1373	40	39	%	%	NOUN
dti-1373	40	40	coomassie	coomassie	ADJ
dti-1373	40	41	brilliant	brilliant	ADJ
dti-1373	40	42	blue	blue	PROPN
dti-1373	40	43	r-250	r-250	PROPN
dti-1373	40	44	and	and	CCONJ
dti-1373	40	45	destained	destain	VERB
dti-1373	40	46	in	in	ADP
dti-1373	40	47	10	10	NUM
dti-1373	40	48	%	%	NOUN
dti-1373	40	49	acetic	acetic	ADJ
dti-1373	40	50	acid	acid	NOUN
dti-1373	40	51	,	,	PUNCT
dti-1373	40	52	30	30	NUM
dti-1373	40	53	%	%	NOUN
dti-1373	40	54	methanol	methanol	NOUN
dti-1373	40	55	in	in	ADP
dti-1373	40	56	h2o	h2o	PROPN
dti-1373	40	57	.	.	PUNCT
dti-1373	41	1	gelatinolytic	gelatinolytic	ADJ
dti-1373	41	2	activity	activity	NOUN
dti-1373	41	3	was	be	AUX
dti-1373	41	4	detected	detect	VERB
dti-1373	41	5	as	as	ADP
dti-1373	41	6	unstained	unstaine	VERB
dti-1373	41	7	bands	band	NOUN
dti-1373	41	8	on	on	ADP
dti-1373	41	9	a	a	DET
dti-1373	41	10	blue	blue	ADJ
dti-1373	41	11	background	background	NOUN
dti-1373	41	12	.	.	PUNCT
dti-1373	42	1	total	total	ADJ
dti-1373	42	2	rna	rna	NOUN
dti-1373	42	3	isolation	isolation	NOUN
dti-1373	42	4	,	,	PUNCT
dti-1373	42	5	cdna	cdna	NOUN
dti-1373	42	6	synthesis	synthesis	NOUN
dti-1373	42	7	and	and	CCONJ
dti-1373	42	8	real	real	ADJ
dti-1373	42	9	-	-	PUNCT
dti-1373	42	10	time	time	NOUN
dti-1373	42	11	quantitative	quantitative	ADJ
dti-1373	42	12	rt	rt	ADJ
dti-1373	42	13	-	-	PUNCT
dti-1373	42	14	pcr	pcr	PROPN
dti-1373	42	15	total	total	NOUN
dti-1373	42	16	rna	rna	NOUN
dti-1373	42	17	was	be	AUX
dti-1373	42	18	extracted	extract	VERB
dti-1373	42	19	from	from	ADP
dti-1373	42	20	cell	cell	NOUN
dti-1373	42	21	monolayers	monolayer	NOUN
dti-1373	42	22	using	use	VERB
dti-1373	42	23	trizol	trizol	ADJ
dti-1373	42	24	reagent	reagent	ADJ
dti-1373	42	25	(	(	PUNCT
dti-1373	42	26	life	life	NOUN
dti-1373	42	27	technologies	technology	NOUN
dti-1373	42	28	,	,	PUNCT
dti-1373	42	29	gaithersburg	gaithersburg	PROPN
dti-1373	42	30	,	,	PUNCT
dti-1373	42	31	md	md	PROPN
dti-1373	42	32	)	)	PUNCT
dti-1373	42	33	.	.	PUNCT
dti-1373	43	1	for	for	ADP
dti-1373	43	2	cdna	cdna	PROPN
dti-1373	43	3	synthesis	synthesis	NOUN
dti-1373	43	4	,	,	PUNCT
dti-1373	43	5	2	2	NUM
dti-1373	43	6	µg	µg	NOUN
dti-1373	43	7	of	of	ADP
dti-1373	43	8	total	total	ADJ
dti-1373	43	9	rna	rna	NOUN
dti-1373	43	10	were	be	AUX
dti-1373	43	11	reversetranscribed	reversetranscribe	VERB
dti-1373	43	12	using	use	VERB
dti-1373	43	13	a	a	DET
dti-1373	43	14	high	high	ADJ
dti-1373	43	15	capacity	capacity	NOUN
dti-1373	43	16	cdna	cdna	NOUN
dti-1373	43	17	reverse	reverse	VERB
dti-1373	43	18	transcription	transcription	NOUN
dti-1373	43	19	kit	kit	NOUN
dti-1373	43	20	(	(	PUNCT
dti-1373	43	21	applied	apply	VERB
dti-1373	43	22	biosystems	biosystem	NOUN
dti-1373	43	23	,	,	PUNCT
dti-1373	43	24	foster	foster	ADJ
dti-1373	43	25	city	city	NOUN
dti-1373	43	26	,	,	PUNCT
dti-1373	43	27	ca	ca	NOUN
dti-1373	43	28	)	)	PUNCT
dti-1373	43	29	.	.	PUNCT
dti-1373	44	1	cdna	cdna	PROPN
dti-1373	44	2	was	be	AUX
dti-1373	44	3	stored	store	VERB
dti-1373	44	4	at	at	ADP
dti-1373	44	5	-80	-80	NOUN
dti-1373	44	6	°	°	ADP
dti-1373	44	7	c	c	NOUN
dti-1373	44	8	prior	prior	ADV
dti-1373	44	9	to	to	ADP
dti-1373	44	10	pcr	pcr	PROPN
dti-1373	44	11	.	.	PUNCT
dti-1373	45	1	gene	gene	NOUN
dti-1373	45	2	expression	expression	NOUN
dti-1373	45	3	was	be	AUX
dti-1373	45	4	quantified	quantify	VERB
dti-1373	45	5	by	by	ADP
dti-1373	45	6	real	real	ADJ
dti-1373	45	7	-	-	PUNCT
dti-1373	45	8	time	time	NOUN
dti-1373	45	9	quantitative	quantitative	ADJ
dti-1373	45	10	pcr	pcr	NOUN
dti-1373	45	11	using	use	VERB
dti-1373	45	12	iq	iq	NOUN
dti-1373	45	13	sybr	sybr	PROPN
dti-1373	45	14	green	green	ADJ
dti-1373	45	15	supermix	supermix	PROPN
dti-1373	45	16	(	(	PUNCT
dti-1373	45	17	bio	bio	NOUN
dti-1373	45	18	-	-	PROPN
dti-1373	45	19	rad	rad	PROPN
dti-1373	45	20	,	,	PUNCT
dti-1373	45	21	hercules	hercule	NOUN
dti-1373	45	22	,	,	PUNCT
dti-1373	45	23	ca	ca	NOUN
dti-1373	45	24	)	)	PUNCT
dti-1373	45	25	.	.	PUNCT
dti-1373	46	1	dna	dna	PROPN
dti-1373	46	2	amplification	amplification	NOUN
dti-1373	46	3	was	be	AUX
dti-1373	46	4	carried	carry	VERB
dti-1373	46	5	out	out	ADP
dti-1373	46	6	using	use	VERB
dti-1373	46	7	an	an	DET
dti-1373	46	8	icycler	icycler	NOUN
dti-1373	46	9	iq5	iq5	NOUN
dti-1373	46	10	(	(	PUNCT
dti-1373	46	11	bio	bio	NOUN
dti-1373	46	12	-	-	PROPN
dti-1373	46	13	rad	rad	PROPN
dti-1373	46	14	,	,	PUNCT
dti-1373	46	15	hercules	hercule	NOUN
dti-1373	46	16	,	,	PUNCT
dti-1373	46	17	ca	ca	NOUN
dti-1373	46	18	)	)	PUNCT
dti-1373	46	19	and	and	CCONJ
dti-1373	46	20	product	product	NOUN
dti-1373	46	21	detection	detection	NOUN
dti-1373	46	22	was	be	AUX
dti-1373	46	23	performed	perform	VERB
dti-1373	46	24	by	by	ADP
dti-1373	46	25	measuring	measure	VERB
dti-1373	46	26	binding	bind	VERB
dti-1373	46	27	of	of	ADP
dti-1373	46	28	the	the	DET
dti-1373	46	29	fluorescent	fluorescent	ADJ
dti-1373	46	30	dye	dye	NOUN
dti-1373	47	1	sybr	sybr	ADP
dti-1373	47	2	green	green	ADJ
dti-1373	47	3	i	i	PRON
dti-1373	47	4	to	to	ADP
dti-1373	47	5	double	double	ADV
dti-1373	47	6	-	-	PUNCT
dti-1373	47	7	stranded	strand	VERB
dti-1373	47	8	dna	dna	NOUN
dti-1373	47	9	.	.	PUNCT
dti-1373	48	1	the	the	DET
dti-1373	48	2	quantitect	quantitect	ADJ
dti-1373	48	3	primer	primer	NOUN
dti-1373	48	4	sets	set	NOUN
dti-1373	48	5	were	be	AUX
dti-1373	48	6	provided	provide	VERB
dti-1373	48	7	by	by	ADP
dti-1373	48	8	qiagen	qiagen	PROPN
dti-1373	48	9	(	(	PUNCT
dti-1373	48	10	valencia	valencia	PROPN
dti-1373	48	11	,	,	PUNCT
dti-1373	48	12	ca	ca	NOUN
dti-1373	48	13	):	):	PUNCT
dti-1373	48	14	mmp-9	mmp-9	X
dti-1373	48	15	(	(	PUNCT
dti-1373	48	16	qt00040040	qt00040040	NOUN
dti-1373	48	17	)	)	PUNCT
dti-1373	48	18	,	,	PUNCT
dti-1373	48	19	cox-2	cox-2	PRON
dti-1373	48	20	(	(	PUNCT
dti-1373	48	21	qt00040586	qt00040586	ADJ
dti-1373	48	22	)	)	PUNCT
dti-1373	48	23	,	,	PUNCT
dti-1373	48	24	β	β	X
dti-1373	48	25	-	-	PUNCT
dti-1373	48	26	actin	actin	NOUN
dti-1373	48	27	(	(	PUNCT
dti-1373	48	28	qt01136772	qt01136772	NOUN
dti-1373	48	29	)	)	PUNCT
dti-1373	48	30	.	.	PUNCT
dti-1373	49	1	gapdh	gapdh	NOUN
dti-1373	49	2	primer	primer	NOUN
dti-1373	49	3	sets	set	NOUN
dti-1373	49	4	were	be	AUX
dti-1373	49	5	synthesized	synthesize	VERB
dti-1373	49	6	by	by	ADP
dti-1373	49	7	biocorp	biocorp	PROPN
dti-1373	49	8	(	(	PUNCT
dti-1373	49	9	dollard	dollard	NOUN
dti-1373	49	10	-	-	PUNCT
dti-1373	49	11	des	des	PROPN
dti-1373	49	12	-	-	PUNCT
dti-1373	49	13	ormeaux	ormeaux	ADJ
dti-1373	49	14	,	,	PUNCT
dti-1373	49	15	qc	qc	PROPN
dti-1373	49	16	)	)	PUNCT
dti-1373	49	17	with	with	ADP
dti-1373	49	18	the	the	DET
dti-1373	49	19	following	follow	VERB
dti-1373	49	20	sequences	sequence	NOUN
dti-1373	49	21	:	:	PUNCT
dti-1373	49	22	forward	forward	ADV
dti-1373	49	23	ccatcaccatcttccaggag	ccatcaccatcttccaggag	ADJ
dti-1373	49	24	and	and	CCONJ
dti-1373	49	25	reverse	reverse	VERB
dti-1373	49	26	cctgcttcaccaccttcttg	cctgcttcaccaccttcttg	NOUN
dti-1373	49	27	.	.	PUNCT
dti-1373	50	1	the	the	DET
dti-1373	50	2	relative	relative	ADJ
dti-1373	50	3	quantities	quantity	NOUN
dti-1373	50	4	of	of	ADP
dti-1373	50	5	target	target	NOUN
dti-1373	50	6	gene	gene	NOUN
dti-1373	50	7	mrna	mrna	NOUN
dti-1373	50	8	compared	compare	VERB
dti-1373	50	9	against	against	ADP
dti-1373	50	10	two	two	NUM
dti-1373	50	11	internal	internal	ADJ
dti-1373	50	12	controls	control	NOUN
dti-1373	50	13	,	,	PUNCT
dti-1373	50	14	gapdh	gapdh	NOUN
dti-1373	50	15	and	and	CCONJ
dti-1373	50	16	β	β	NOUN
dti-1373	50	17	-	-	PUNCT
dti-1373	50	18	actin	actin	NOUN
dti-1373	50	19	mrna	mrna	PROPN
dti-1373	50	20	,	,	PUNCT
dti-1373	50	21	were	be	AUX
dti-1373	50	22	measured	measure	VERB
dti-1373	50	23	by	by	ADP
dti-1373	50	24	following	follow	VERB
dti-1373	50	25	a	a	DET
dti-1373	50	26	∆ct	∆ct	NOUN
dti-1373	50	27	method	method	NOUN
dti-1373	50	28	employing	employ	VERB
dti-1373	50	29	an	an	DET
dti-1373	50	30	amplification	amplification	NOUN
dti-1373	50	31	plot	plot	NOUN
dti-1373	50	32	(	(	PUNCT
dti-1373	50	33	fluorescence	fluorescence	NOUN
dti-1373	50	34	signal	signal	NOUN
dti-1373	50	35	vs.	vs.	ADP
dti-1373	50	36	cycle	cycle	NOUN
dti-1373	50	37	number	number	NOUN
dti-1373	50	38	)	)	PUNCT
dti-1373	50	39	.	.	PUNCT
dti-1373	51	1	the	the	DET
dti-1373	51	2	difference	difference	NOUN
dti-1373	51	3	(	(	PUNCT
dti-1373	51	4	∆ct	∆ct	NOUN
dti-1373	51	5	)	)	PUNCT
dti-1373	51	6	between	between	ADP
dti-1373	51	7	the	the	DET
dti-1373	51	8	mean	mean	ADJ
dti-1373	51	9	values	value	NOUN
dti-1373	51	10	in	in	ADP
dti-1373	51	11	the	the	DET
dti-1373	51	12	triplicate	triplicate	NOUN
dti-1373	51	13	samples	sample	NOUN
dti-1373	51	14	of	of	ADP
dti-1373	51	15	target	target	NOUN
dti-1373	51	16	gene	gene	NOUN
dti-1373	51	17	and	and	CCONJ
dti-1373	51	18	those	those	PRON
dti-1373	51	19	of	of	ADP
dti-1373	51	20	gapdh	gapdh	NOUN
dti-1373	51	21	and	and	CCONJ
dti-1373	51	22	β	β	NOUN
dti-1373	51	23	-	-	PUNCT
dti-1373	51	24	actin	actin	NOUN
dti-1373	51	25	mrnas	mrna	NOUN
dti-1373	51	26	were	be	AUX
dti-1373	51	27	calculated	calculate	VERB
dti-1373	51	28	by	by	ADP
dti-1373	51	29	iq5	iq5	PROPN
dti-1373	51	30	optical	optical	ADJ
dti-1373	51	31	system	system	NOUN
dti-1373	51	32	software	software	NOUN
dti-1373	51	33	version	version	NOUN
dti-1373	51	34	2.0	2.0	NUM
dti-1373	51	35	(	(	PUNCT
dti-1373	51	36	biorad	biorad	NOUN
dti-1373	51	37	,	,	PUNCT
dti-1373	51	38	hercules	hercule	NOUN
dti-1373	51	39	,	,	PUNCT
dti-1373	51	40	ca	ca	NOUN
dti-1373	51	41	)	)	PUNCT
dti-1373	51	42	and	and	CCONJ
dti-1373	51	43	the	the	DET
dti-1373	51	44	relative	relative	ADJ
dti-1373	51	45	quantified	quantified	ADJ
dti-1373	51	46	value	value	NOUN
dti-1373	51	47	(	(	PUNCT
dti-1373	51	48	rqv	rqv	NOUN
dti-1373	51	49	)	)	PUNCT
dti-1373	51	50	was	be	AUX
dti-1373	51	51	expressed	express	VERB
dti-1373	51	52	as	as	ADP
dti-1373	51	53	2-∆c	2-∆c	NUM
dti-1373	51	54	t.	t.	NOUN
dti-1373	51	55	tissuescan	tissuescan	PROPN
dti-1373	51	56	cdna	cdna	PROPN
dti-1373	51	57	arrays	array	NOUN
dti-1373	51	58	of	of	ADP
dti-1373	51	59	grade	grade	NOUN
dti-1373	51	60	i	i	PROPN
dti-1373	51	61	-	-	PUNCT
dti-1373	51	62	iv	iv	NUM
dti-1373	51	63	brain	brain	NOUN
dti-1373	51	64	tumour	tumour	NOUN
dti-1373	51	65	tissues	tissue	NOUN
dti-1373	51	66	tissuescan	tissuescan	VERB
dti-1373	51	67	™	™	ADJ
dti-1373	51	68	cancer	cancer	NOUN
dti-1373	51	69	and	and	CCONJ
dti-1373	51	70	normal	normal	ADJ
dti-1373	51	71	tissue	tissue	NOUN
dti-1373	51	72	cdna	cdna	NOUN
dti-1373	51	73	arrays	array	VERB
dti-1373	51	74	were	be	AUX
dti-1373	51	75	purchased	purchase	VERB
dti-1373	51	76	from	from	ADP
dti-1373	51	77	origene	origene	NOUN
dti-1373	51	78	(	(	PUNCT
dti-1373	51	79	rockville	rockville	PROPN
dti-1373	51	80	,	,	PUNCT
dti-1373	51	81	md	md	PROPN
dti-1373	51	82	)	)	PUNCT
dti-1373	51	83	,	,	PUNCT
dti-1373	51	84	covered	cover	VERB
dti-1373	51	85	43	43	NUM
dti-1373	51	86	clinical	clinical	ADJ
dti-1373	51	87	samples	sample	NOUN
dti-1373	51	88	of	of	ADP
dti-1373	51	89	the	the	DET
dti-1373	51	90	brain	brain	NOUN
dti-1373	51	91	cancer	cancer	NOUN
dti-1373	51	92	four	four	NUM
dti-1373	51	93	stages	stage	NOUN
dti-1373	51	94	and	and	CCONJ
dti-1373	51	95	normal	normal	ADJ
dti-1373	51	96	tissues	tissue	NOUN
dti-1373	51	97	,	,	PUNCT
dti-1373	51	98	and	and	CCONJ
dti-1373	51	99	were	be	AUX
dti-1373	51	100	used	use	VERB
dti-1373	51	101	to	to	PART
dti-1373	51	102	analyze	analyze	VERB
dti-1373	51	103	differential	differential	ADJ
dti-1373	51	104	sirt1	sirt1	NOUN
dti-1373	51	105	gene	gene	NOUN
dti-1373	51	106	expression	expression	NOUN
dti-1373	51	107	according	accord	VERB
dti-1373	51	108	to	to	ADP
dti-1373	51	109	the	the	DET
dti-1373	51	110	manufacturer	manufacturer	NOUN
dti-1373	51	111	’s	’s	PART
dti-1373	51	112	recommendation	recommendation	NOUN
dti-1373	51	113	.	.	PUNCT
dti-1373	52	1	tissue	tissue	NOUN
dti-1373	52	2	cdnas	cdna	NOUN
dti-1373	52	3	of	of	ADP
dti-1373	52	4	each	each	DET
dti-1373	52	5	array	array	NOUN
dti-1373	52	6	are	be	AUX
dti-1373	52	7	synthesized	synthesize	VERB
dti-1373	52	8	from	from	ADP
dti-1373	52	9	high	high	ADJ
dti-1373	52	10	quality	quality	NOUN
dti-1373	52	11	total	total	ADJ
dti-1373	52	12	rnas	rna	NOUN
dti-1373	52	13	of	of	ADP
dti-1373	52	14	pathologist	pathologist	NOUN
dti-1373	52	15	-	-	PUNCT
dti-1373	52	16	verified	verify	VERB
dti-1373	52	17	tissues	tissue	NOUN
dti-1373	52	18	,	,	PUNCT
dti-1373	52	19	normalized	normalize	VERB
dti-1373	52	20	and	and	CCONJ
dti-1373	52	21	validated	validate	VERB
dti-1373	52	22	with	with	ADP
dti-1373	52	23	β	β	NOUN
dti-1373	52	24	-	-	NOUN
dti-1373	52	25	actin	actin	NOUN
dti-1373	52	26	in	in	ADP
dti-1373	52	27	two	two	NUM
dti-1373	52	28	sequential	sequential	ADJ
dti-1373	52	29	qpcr	qpcr	ADJ
dti-1373	52	30	analyses	analysis	NOUN
dti-1373	52	31	,	,	PUNCT
dti-1373	52	32	and	and	CCONJ
dti-1373	52	33	provided	provide	VERB
dti-1373	52	34	with	with	ADP
dti-1373	52	35	clinical	clinical	ADJ
dti-1373	52	36	information	information	NOUN
dti-1373	52	37	for	for	ADP
dti-1373	52	38	2	2	NUM
dti-1373	52	39	normal	normal	ADJ
dti-1373	52	40	brain	brain	NOUN
dti-1373	52	41	,	,	PUNCT
dti-1373	52	42	18	18	NUM
dti-1373	52	43	who	who	PRON
dti-1373	52	44	grade	grade	VERB
dti-1373	52	45	i	i	PRON
dti-1373	52	46	,	,	PUNCT
dti-1373	52	47	11	11	NUM
dti-1373	52	48	who	who	PRON
dti-1373	52	49	grade	grade	PROPN
dti-1373	52	50	ii	ii	PROPN
dti-1373	52	51	,	,	PUNCT
dti-1373	52	52	10	10	NUM
dti-1373	52	53	who	who	PRON
dti-1373	52	54	grade	grade	NOUN
dti-1373	52	55	iii	iii	PROPN
dti-1373	52	56	,	,	PUNCT
dti-1373	52	57	and	and	CCONJ
dti-1373	52	58	2	2	NUM
dti-1373	52	59	who	who	PRON
dti-1373	52	60	grade	grade	NOUN
dti-1373	52	61	iv	iv	NUM
dti-1373	52	62	brain	brain	NOUN
dti-1373	52	63	tumours	tumours	NOUN
dti-1373	52	64	.	.	PUNCT
dti-1373	53	1	transfection	transfection	NOUN
dti-1373	53	2	method	method	NOUN
dti-1373	53	3	and	and	CCONJ
dti-1373	53	4	rna	rna	NOUN
dti-1373	53	5	interference	interference	NOUN
dti-1373	53	6	cells	cell	NOUN
dti-1373	53	7	were	be	AUX
dti-1373	53	8	transiently	transiently	ADV
dti-1373	53	9	transfected	transfecte	VERB
dti-1373	53	10	with	with	ADP
dti-1373	53	11	20	20	NUM
dti-1373	53	12	nm	nm	PROPN
dti-1373	53	13	sirna	sirna	PROPN
dti-1373	53	14	(	(	PUNCT
dti-1373	53	15	qiagen	qiagen	PROPN
dti-1373	53	16	)	)	PUNCT
dti-1373	53	17	against	against	ADP
dti-1373	53	18	sirt1	sirt1	NOUN
dti-1373	53	19	(	(	PUNCT
dti-1373	53	20	hs_sirt1_1	hs_sirt1_1	PROPN
dti-1373	53	21	flexitube	flexitube	PROPN
dti-1373	53	22	sirna	sirna	PROPN
dti-1373	53	23	,	,	PUNCT
dti-1373	53	24	si00098434	si00098434	PROPN
dti-1373	53	25	)	)	PUNCT
dti-1373	53	26	or	or	CCONJ
dti-1373	53	27	scrambled	scramble	VERB
dti-1373	53	28	sequences	sequence	NOUN
dti-1373	53	29	(	(	PUNCT
dti-1373	53	30	allstar	allstar	PROPN
dti-1373	53	31	negative	negative	PROPN
dti-1373	53	32	control	control	PROPN
dti-1373	53	33	sirna	sirna	PROPN
dti-1373	53	34	,	,	PUNCT
dti-1373	53	35	1027281	1027281	NUM
dti-1373	53	36	)	)	PUNCT
dti-1373	53	37	using	use	VERB
dti-1373	53	38	lipofectamine	lipofectamine	ADJ
dti-1373	53	39	2000	2000	NUM
dti-1373	53	40	(	(	PUNCT
dti-1373	53	41	invitrogen	invitrogen	PROPN
dti-1373	53	42	,	,	PUNCT
dti-1373	53	43	on	on	ADP
dti-1373	53	44	)	)	PUNCT
dti-1373	53	45	.	.	PUNCT
dti-1373	54	1	specific	specific	ADJ
dti-1373	54	2	gene	gene	NOUN
dti-1373	54	3	knockdown	knockdown	NOUN
dti-1373	54	4	was	be	AUX
dti-1373	54	5	evaluated	evaluate	VERB
dti-1373	54	6	by	by	ADP
dti-1373	54	7	qrt	qrt	NOUN
dti-1373	54	8	-	-	PUNCT
dti-1373	54	9	pcr	pcr	NOUN
dti-1373	54	10	as	as	SCONJ
dti-1373	54	11	described	describe	VERB
dti-1373	54	12	above	above	ADV
dti-1373	54	13	.	.	PUNCT
dti-1373	55	1	small	small	ADJ
dti-1373	55	2	interfering	interfere	VERB
dti-1373	55	3	rna	rna	PROPN
dti-1373	55	4	and	and	CCONJ
dti-1373	55	5	mismatch	mismatch	PROPN
dti-1373	55	6	sirna	sirna	PROPN
dti-1373	55	7	were	be	AUX
dti-1373	55	8	synthesized	synthesize	VERB
dti-1373	55	9	by	by	ADP
dti-1373	55	10	qiagen	qiagen	PROPN
dti-1373	55	11	(	(	PUNCT
dti-1373	55	12	valencia	valencia	PROPN
dti-1373	55	13	,	,	PUNCT
dti-1373	55	14	ca	ca	NOUN
dti-1373	55	15	)	)	PUNCT
dti-1373	55	16	and	and	CCONJ
dti-1373	55	17	annealed	anneal	VERB
dti-1373	55	18	to	to	PART
dti-1373	55	19	form	form	VERB
dti-1373	55	20	duplexes	duplex	NOUN
dti-1373	55	21	.	.	PUNCT
dti-1373	56	1	statistical	statistical	ADJ
dti-1373	56	2	data	datum	NOUN
dti-1373	56	3	analysis	analysis	NOUN
dti-1373	56	4	data	datum	NOUN
dti-1373	56	5	statistical	statistical	ADJ
dti-1373	56	6	significance	significance	NOUN
dti-1373	56	7	(	(	PUNCT
dti-1373	56	8	p	p	NOUN
dti-1373	56	9	values	value	NOUN
dti-1373	56	10	,	,	PUNCT
dti-1373	56	11	0.05	0.05	NUM
dti-1373	56	12	)	)	PUNCT
dti-1373	56	13	was	be	AUX
dti-1373	56	14	assessed	assess	VERB
dti-1373	56	15	using	use	VERB
dti-1373	56	16	student	student	NOUN
dti-1373	56	17	’s	’s	PART
dti-1373	56	18	unpaired	unpaired	ADJ
dti-1373	56	19	t	t	NOUN
dti-1373	56	20	-	-	PUNCT
dti-1373	56	21	test	test	NOUN
dti-1373	56	22	from	from	ADP
dti-1373	56	23	three	three	NUM
dti-1373	56	24	or	or	CCONJ
dti-1373	56	25	more	more	ADV
dti-1373	56	26	independent	independent	ADJ
dti-1373	56	27	experiments	experiment	NOUN
dti-1373	56	28	.	.	PUNCT
dti-1373	57	1	results	result	VERB
dti-1373	57	2	sirt1	sirt1	NOUN
dti-1373	57	3	gene	gene	NOUN
dti-1373	57	4	expression	expression	NOUN
dti-1373	57	5	profiling	profiling	NOUN
dti-1373	57	6	in	in	ADP
dti-1373	57	7	grade	grade	NOUN
dti-1373	57	8	i	i	PROPN
dti-1373	57	9	-	-	PUNCT
dti-1373	57	10	iv	iv	NUM
dti-1373	57	11	brain	brain	NOUN
dti-1373	57	12	tumour	tumour	NOUN
dti-1373	57	13	tissues	tissue	NOUN
dti-1373	57	14	fourthy	fourthy	ADJ
dti-1373	57	15	-	-	PUNCT
dti-1373	57	16	eight	eight	NUM
dti-1373	57	17	clinical	clinical	ADJ
dti-1373	57	18	tissue	tissue	NOUN
dti-1373	57	19	samples	sample	NOUN
dti-1373	57	20	were	be	AUX
dti-1373	57	21	first	first	ADV
dti-1373	57	22	analyzed	analyze	VERB
dti-1373	57	23	for	for	ADP
dti-1373	57	24	sirt1	sirt1	NOUN
dti-1373	57	25	gene	gene	NOUN
dti-1373	57	26	expression	expression	NOUN
dti-1373	57	27	profil	profil	NOUN
dti-1373	57	28	using	use	VERB
dti-1373	57	29	tissuescan	tissuescan	ADJ
dti-1373	57	30	™	™	ADJ
dti-1373	57	31	cancer	cancer	NOUN
dti-1373	57	32	and	and	CCONJ
dti-1373	57	33	normal	normal	ADJ
dti-1373	57	34	tissue	tissue	NOUN
dti-1373	57	35	cdna	cdna	NOUN
dti-1373	57	36	arrays	array	VERB
dti-1373	57	37	(	(	PUNCT
dti-1373	57	38	origene	origene	NOUN
dti-1373	57	39	,	,	PUNCT
dti-1373	57	40	rockville	rockville	PROPN
dti-1373	57	41	,	,	PUNCT
dti-1373	57	42	md	md	PROPN
dti-1373	57	43	)	)	PUNCT
dti-1373	57	44	from	from	ADP
dti-1373	57	45	43	43	NUM
dti-1373	57	46	clinical	clinical	ADJ
dti-1373	57	47	samples	sample	NOUN
dti-1373	57	48	covering	cover	VERB
dti-1373	57	49	brain	brain	NOUN
dti-1373	57	50	cancer	cancer	NOUN
dti-1373	57	51	four	four	NUM
dti-1373	57	52	stages	stage	NOUN
dti-1373	57	53	and	and	CCONJ
dti-1373	57	54	normal	normal	ADJ
dti-1373	57	55	tissues	tissue	NOUN
dti-1373	57	56	as	as	SCONJ
dti-1373	57	57	described	describe	VERB
dti-1373	57	58	in	in	ADP
dti-1373	57	59	the	the	DET
dti-1373	57	60	methods	method	NOUN
dti-1373	57	61	section	section	NOUN
dti-1373	57	62	.	.	PUNCT
dti-1373	58	1	we	we	PRON
dti-1373	58	2	found	find	VERB
dti-1373	58	3	that	that	SCONJ
dti-1373	58	4	sirt1	sirt1	NOUN
dti-1373	58	5	gene	gene	NOUN
dti-1373	58	6	expression	expression	NOUN
dti-1373	58	7	levels	level	NOUN
dti-1373	58	8	increased	increase	VERB
dti-1373	58	9	from	from	ADP
dti-1373	58	10	grade	grade	NOUN
dti-1373	58	11	i	i	PROPN
dti-1373	58	12	to	to	ADP
dti-1373	58	13	grade	grade	NOUN
dti-1373	58	14	iii	iii	NUM
dti-1373	58	15	brain	brain	NOUN
dti-1373	58	16	tumour	tumour	NOUN
dti-1373	58	17	tissues	tissue	NOUN
dti-1373	58	18	(	(	PUNCT
dti-1373	58	19	fig	fig	NOUN
dti-1373	58	20	.	.	PUNCT
dti-1373	59	1	1	1	NUM
dti-1373	59	2	,	,	PUNCT
dti-1373	59	3	black	black	ADJ
dti-1373	59	4	bars	bar	NOUN
dti-1373	59	5	)	)	PUNCT
dti-1373	59	6	,	,	PUNCT
dti-1373	59	7	but	but	CCONJ
dti-1373	59	8	not	not	PART
dti-1373	59	9	in	in	ADP
dti-1373	59	10	grade	grade	NOUN
dti-1373	59	11	iv	iv	NUM
dti-1373	59	12	as	as	SCONJ
dti-1373	59	13	compared	compare	VERB
dti-1373	59	14	to	to	ADP
dti-1373	59	15	normal	normal	ADJ
dti-1373	59	16	brain	brain	NOUN
dti-1373	59	17	tissue	tissue	NOUN
dti-1373	59	18	(	(	PUNCT
dti-1373	59	19	fig	fig	NOUN
dti-1373	59	20	.	.	PUNCT
dti-1373	60	1	1	1	NUM
dti-1373	60	2	,	,	PUNCT
dti-1373	60	3	white	white	ADJ
dti-1373	60	4	bars	bar	NOUN
dti-1373	60	5	)	)	PUNCT
dti-1373	60	6	.	.	PUNCT
dti-1373	61	1	this	this	PRON
dti-1373	61	2	suggests	suggest	VERB
dti-1373	61	3	that	that	SCONJ
dti-1373	61	4	discrepancy	discrepancy	NOUN
dti-1373	61	5	found	find	VERB
dti-1373	61	6	in	in	ADP
dti-1373	61	7	the	the	DET
dti-1373	61	8	literature	literature	NOUN
dti-1373	61	9	regarding	regard	VERB
dti-1373	61	10	sirt1	sirt1	NOUN
dti-1373	61	11	expression	expression	NOUN
dti-1373	61	12	in	in	ADP
dti-1373	61	13	tissue	tissue	NOUN
dti-1373	61	14	samples	sample	NOUN
dti-1373	61	15	may	may	AUX
dti-1373	61	16	be	be	AUX
dti-1373	61	17	explained	explain	VERB
dti-1373	61	18	by	by	ADP
dti-1373	61	19	the	the	DET
dti-1373	61	20	invasive	invasive	ADJ
dti-1373	61	21	stage	stage	NOUN
dti-1373	61	22	status	status	NOUN
dti-1373	61	23	of	of	ADP
dti-1373	61	24	a	a	DET
dti-1373	61	25	given	give	VERB
dti-1373	61	26	tumour	tumour	NOUN
dti-1373	61	27	.	.	PUNCT
dti-1373	62	1	given	give	VERB
dti-1373	62	2	that	that	SCONJ
dti-1373	62	3	tumour	tumour	NOUN
dti-1373	62	4	samples	sample	NOUN
dti-1373	62	5	are	be	AUX
dti-1373	62	6	composed	compose	VERB
dti-1373	62	7	of	of	ADP
dti-1373	62	8	a	a	DET
dti-1373	62	9	heterogeneous	heterogeneous	ADJ
dti-1373	62	10	cell	cell	NOUN
dti-1373	62	11	composition	composition	NOUN
dti-1373	62	12	including	include	VERB
dti-1373	62	13	http://www.la-press.com	http://www.la-press.com	X
dti-1373	62	14	annabi	annabi	PROPN
dti-1373	62	15	et	et	PROPN
dti-1373	62	16	al	al	PROPN
dti-1373	62	17	4	4	NUM
dti-1373	62	18	drug	drug	NOUN
dti-1373	62	19	target	target	NOUN
dti-1373	62	20	insights	insight	NOUN
dti-1373	62	21	2012:6	2012:6	NUM
dti-1373	62	22	cancer	cancer	NOUN
dti-1373	62	23	,	,	PUNCT
dti-1373	62	24	inflammatory	inflammatory	ADJ
dti-1373	62	25	,	,	PUNCT
dti-1373	62	26	as	as	ADV
dti-1373	62	27	well	well	ADV
dti-1373	62	28	as	as	ADP
dti-1373	62	29	endothelial	endothelial	ADJ
dti-1373	62	30	cells	cell	NOUN
dti-1373	62	31	,	,	PUNCT
dti-1373	62	32	we	we	PRON
dti-1373	62	33	decided	decide	VERB
dti-1373	62	34	to	to	PART
dti-1373	62	35	focus	focus	VERB
dti-1373	62	36	our	our	PRON
dti-1373	62	37	study	study	NOUN
dti-1373	62	38	on	on	ADP
dti-1373	62	39	the	the	DET
dti-1373	62	40	sirt1	sirt1	NOUN
dti-1373	62	41	contribution	contribution	NOUN
dti-1373	62	42	within	within	ADP
dti-1373	62	43	a	a	DET
dti-1373	62	44	carcinogen	carcinogen	NOUN
dti-1373	62	45	-	-	PUNCT
dti-1373	62	46	treated	treat	VERB
dti-1373	62	47	brainassociated	brainassociate	VERB
dti-1373	62	48	endothelial	endothelial	NOUN
dti-1373	62	49	cell	cell	NOUN
dti-1373	62	50	compartment	compartment	NOUN
dti-1373	62	51	.	.	PUNCT
dti-1373	63	1	resveratrol	resveratrol	NOUN
dti-1373	63	2	dose	dose	NOUN
dti-1373	63	3	-	-	PUNCT
dti-1373	63	4	dependent	dependent	ADJ
dti-1373	63	5	inhibition	inhibition	NOUN
dti-1373	63	6	of	of	ADP
dti-1373	63	7	carcinogen	carcinogen	NOUN
dti-1373	63	8	-	-	PUNCT
dti-1373	63	9	induced	induce	VERB
dti-1373	63	10	cox-2	cox-2	ADJ
dti-1373	63	11	gene	gene	NOUN
dti-1373	63	12	and	and	CCONJ
dti-1373	63	13	protein	protein	NOUN
dti-1373	63	14	expression	expression	NOUN
dti-1373	63	15	various	various	ADJ
dti-1373	63	16	molecular	molecular	ADJ
dti-1373	63	17	mechanisms	mechanism	NOUN
dti-1373	63	18	mediate	mediate	VERB
dti-1373	63	19	inflammatory	inflammatory	ADJ
dti-1373	63	20	processes	process	NOUN
dti-1373	63	21	and	and	CCONJ
dti-1373	63	22	angiogenesis	angiogenesis	NOUN
dti-1373	63	23	,	,	PUNCT
dti-1373	63	24	one	one	NUM
dti-1373	63	25	of	of	ADP
dti-1373	63	26	which	which	PRON
dti-1373	63	27	is	be	AUX
dti-1373	63	28	reflected	reflect	VERB
dti-1373	63	29	by	by	ADP
dti-1373	63	30	increased	increase	VERB
dti-1373	63	31	expression	expression	NOUN
dti-1373	63	32	of	of	ADP
dti-1373	63	33	the	the	DET
dti-1373	63	34	inflammatory	inflammatory	ADJ
dti-1373	63	35	biomarker	biomarker	NOUN
dti-1373	63	36	cox-2.7	cox-2.7	VERB
dti-1373	63	37	in	in	ADP
dti-1373	63	38	order	order	NOUN
dti-1373	63	39	to	to	PART
dti-1373	63	40	investigate	investigate	VERB
dti-1373	63	41	the	the	DET
dti-1373	63	42	effect	effect	NOUN
dti-1373	63	43	of	of	ADP
dti-1373	63	44	resveratrol	resveratrol	NOUN
dti-1373	63	45	on	on	ADP
dti-1373	63	46	hbmec	hbmec	NOUN
dti-1373	63	47	-	-	PUNCT
dti-1373	63	48	associated	associate	VERB
dti-1373	63	49	inflammation	inflammation	NOUN
dti-1373	63	50	,	,	PUNCT
dti-1373	63	51	we	we	PRON
dti-1373	63	52	tested	test	VERB
dti-1373	63	53	the	the	DET
dti-1373	63	54	effects	effect	NOUN
dti-1373	63	55	of	of	ADP
dti-1373	63	56	resveratrol	resveratrol	NOUN
dti-1373	63	57	on	on	ADP
dti-1373	63	58	pma	pma	NOUN
dti-1373	63	59	-	-	PUNCT
dti-1373	63	60	induced	induce	VERB
dti-1373	63	61	cell	cell	NOUN
dti-1373	63	62	signaling	signal	VERB
dti-1373	63	63	in	in	ADP
dti-1373	63	64	hbmec	hbmec	NOUN
dti-1373	63	65	by	by	ADP
dti-1373	63	66	western	western	ADJ
dti-1373	63	67	blotting	blotting	NOUN
dti-1373	63	68	.	.	PUNCT
dti-1373	64	1	cells	cell	NOUN
dti-1373	64	2	were	be	AUX
dti-1373	64	3	therefore	therefore	ADV
dti-1373	64	4	treated	treat	VERB
dti-1373	64	5	with	with	ADP
dti-1373	64	6	1	1	NUM
dti-1373	64	7	µm	µm	NOUN
dti-1373	64	8	of	of	ADP
dti-1373	64	9	pma	pma	NOUN
dti-1373	64	10	in	in	ADP
dti-1373	64	11	the	the	DET
dti-1373	64	12	presence	presence	NOUN
dti-1373	64	13	of	of	ADP
dti-1373	64	14	increasing	increase	VERB
dti-1373	64	15	concentrations	concentration	NOUN
dti-1373	64	16	of	of	ADP
dti-1373	64	17	resveratrol	resveratrol	NOUN
dti-1373	64	18	for	for	ADP
dti-1373	64	19	18h	18h	NOUN
dti-1373	64	20	and	and	CCONJ
dti-1373	64	21	cox-2	cox-2	NOUN
dti-1373	64	22	expression	expression	NOUN
dti-1373	64	23	was	be	AUX
dti-1373	64	24	evaluated	evaluate	VERB
dti-1373	64	25	in	in	ADP
dti-1373	64	26	cell	cell	NOUN
dti-1373	64	27	lysates	lysate	NOUN
dti-1373	64	28	by	by	ADP
dti-1373	64	29	western	western	ADJ
dti-1373	64	30	blotting	blot	VERB
dti-1373	64	31	(	(	PUNCT
dti-1373	64	32	fig	fig	NOUN
dti-1373	64	33	.	.	PUNCT
dti-1373	65	1	2a	2a	NUM
dti-1373	65	2	)	)	PUNCT
dti-1373	65	3	.	.	PUNCT
dti-1373	66	1	while	while	SCONJ
dti-1373	66	2	100	100	NUM
dti-1373	66	3	µm	µm	ADP
dti-1373	66	4	resveratrol	resveratrol	NOUN
dti-1373	66	5	was	be	AUX
dti-1373	66	6	without	without	ADP
dti-1373	66	7	effect	effect	NOUN
dti-1373	66	8	on	on	ADP
dti-1373	66	9	cox-2	cox-2	ADJ
dti-1373	66	10	basal	basal	ADJ
dti-1373	66	11	expression	expression	NOUN
dti-1373	66	12	,	,	PUNCT
dti-1373	66	13	it	it	PRON
dti-1373	66	14	significantly	significantly	ADV
dti-1373	66	15	inhibited	inhibit	VERB
dti-1373	66	16	pma	pma	NOUN
dti-1373	66	17	-	-	PUNCT
dti-1373	66	18	induced	induce	VERB
dti-1373	66	19	cox-2	cox-2	ADJ
dti-1373	66	20	protein	protein	NOUN
dti-1373	66	21	expression	expression	NOUN
dti-1373	66	22	(	(	PUNCT
dti-1373	66	23	ic50	ic50	PROPN
dti-1373	66	24	6.1	6.1	NUM
dti-1373	66	25	±	±	NUM
dti-1373	66	26	2.2	2.2	NUM
dti-1373	66	27	µm	µm	NOUN
dti-1373	66	28	,	,	PUNCT
dti-1373	66	29	fig	fig	NOUN
dti-1373	66	30	.	.	PUNCT
dti-1373	66	31	2b	2b	NUM
dti-1373	66	32	)	)	PUNCT
dti-1373	66	33	and	and	CCONJ
dti-1373	66	34	gene	gene	NOUN
dti-1373	66	35	(	(	PUNCT
dti-1373	66	36	fig	fig	NOUN
dti-1373	66	37	.	.	PUNCT
dti-1373	67	1	2c	2c	NOUN
dti-1373	67	2	)	)	PUNCT
dti-1373	67	3	expression	expression	NOUN
dti-1373	67	4	.	.	PUNCT
dti-1373	68	1	resveratrol	resveratrol	NOUN
dti-1373	68	2	inhibition	inhibition	NOUN
dti-1373	68	3	of	of	ADP
dti-1373	68	4	carcinogeninduced	carcinogeninduced	ADJ
dti-1373	68	5	mmp-9	mmp-9	NOUN
dti-1373	68	6	gene	gene	NOUN
dti-1373	68	7	expression	expression	NOUN
dti-1373	68	8	and	and	CCONJ
dti-1373	68	9	protein	protein	NOUN
dti-1373	68	10	secretion	secretion	NOUN
dti-1373	68	11	among	among	ADP
dti-1373	68	12	the	the	DET
dti-1373	68	13	secreted	secrete	VERB
dti-1373	68	14	enzymes	enzyme	NOUN
dti-1373	68	15	involved	involve	VERB
dti-1373	68	16	in	in	ADP
dti-1373	68	17	ecm	ecm	NOUN
dti-1373	68	18	degradation	degradation	NOUN
dti-1373	68	19	,	,	PUNCT
dti-1373	68	20	matrix	matrix	NOUN
dti-1373	68	21	metalloproteinases	metalloproteinase	NOUN
dti-1373	68	22	(	(	PUNCT
dti-1373	68	23	mmp	mmp	PROPN
dti-1373	68	24	)	)	PUNCT
dti-1373	68	25	are	be	AUX
dti-1373	68	26	well	well	ADV
dti-1373	68	27	-	-	PUNCT
dti-1373	68	28	documented	document	VERB
dti-1373	68	29	as	as	ADP
dti-1373	68	30	being	be	AUX
dti-1373	68	31	involved	involve	VERB
dti-1373	68	32	in	in	ADP
dti-1373	68	33	ec	ec	PROPN
dti-1373	68	34	migration	migration	NOUN
dti-1373	68	35	and	and	CCONJ
dti-1373	68	36	tubulogenesis.10,24	tubulogenesis.10,24	NOUN
dti-1373	68	37	mmp-9	mmp-9	NUM
dti-1373	68	38	,	,	PUNCT
dti-1373	68	39	an	an	DET
dti-1373	68	40	enzyme	enzyme	NOUN
dti-1373	68	41	involved	involve	VERB
dti-1373	68	42	in	in	ADP
dti-1373	68	43	the	the	DET
dti-1373	68	44	degradation	degradation	NOUN
dti-1373	68	45	of	of	ADP
dti-1373	68	46	the	the	DET
dti-1373	68	47	extracellular	extracellular	ADJ
dti-1373	68	48	matrix	matrix	NOUN
dti-1373	68	49	(	(	PUNCT
dti-1373	68	50	ecm	ecm	PROPN
dti-1373	68	51	)	)	PUNCT
dti-1373	68	52	,	,	PUNCT
dti-1373	68	53	is	be	AUX
dti-1373	68	54	secreted	secrete	VERB
dti-1373	68	55	by	by	ADP
dti-1373	68	56	a	a	DET
dti-1373	68	57	variety	variety	NOUN
dti-1373	68	58	of	of	ADP
dti-1373	68	59	cells	cell	NOUN
dti-1373	68	60	and	and	CCONJ
dti-1373	68	61	its	its	PRON
dti-1373	68	62	presence	presence	NOUN
dti-1373	68	63	was	be	AUX
dti-1373	68	64	shown	show	VERB
dti-1373	68	65	to	to	PART
dti-1373	68	66	be	be	AUX
dti-1373	68	67	increased	increase	VERB
dti-1373	68	68	upon	upon	SCONJ
dti-1373	68	69	carcinogen	carcinogen	NOUN
dti-1373	68	70	promoting	promote	VERB
dti-1373	68	71	agents	agent	NOUN
dti-1373	68	72	such	such	ADJ
dti-1373	68	73	as	as	ADP
dti-1373	68	74	the	the	DET
dti-1373	68	75	phorbol	phorbol	NOUN
dti-1373	68	76	ester	ester	NOUN
dti-1373	68	77	pma.25–27	pma.25–27	PROPN
dti-1373	68	78	hbmec	hbmec	VERB
dti-1373	68	79	were	be	AUX
dti-1373	68	80	first	first	ADV
dti-1373	68	81	treated	treat	VERB
dti-1373	68	82	for	for	ADP
dti-1373	68	83	18	18	NUM
dti-1373	68	84	h	h	NOUN
dti-1373	68	85	with	with	ADP
dti-1373	68	86	pma	pma	PROPN
dti-1373	68	87	.	.	PUNCT
dti-1373	69	1	gelatin	gelatin	PROPN
dti-1373	69	2	zymography	zymography	PROPN
dti-1373	69	3	was	be	AUX
dti-1373	69	4	then	then	ADV
dti-1373	69	5	used	use	VERB
dti-1373	69	6	to	to	PART
dti-1373	69	7	measure	measure	VERB
dti-1373	69	8	prommp-9	prommp-9	NUM
dti-1373	69	9	levels	level	NOUN
dti-1373	69	10	,	,	PUNCT
dti-1373	69	11	which	which	PRON
dti-1373	69	12	were	be	AUX
dti-1373	69	13	significantly	significantly	ADV
dti-1373	69	14	increased	increase	VERB
dti-1373	69	15	upon	upon	SCONJ
dti-1373	69	16	pma	pma	NOUN
dti-1373	69	17	treatment	treatment	NOUN
dti-1373	69	18	in	in	ADP
dti-1373	69	19	comparison	comparison	NOUN
dti-1373	69	20	to	to	ADP
dti-1373	69	21	vehicle	vehicle	NOUN
dti-1373	69	22	-	-	PUNCT
dti-1373	69	23	treated	treat	VERB
dti-1373	69	24	cells	cell	NOUN
dti-1373	69	25	(	(	PUNCT
dti-1373	69	26	fig	fig	NOUN
dti-1373	69	27	.	.	PUNCT
dti-1373	70	1	3a	3a	NUM
dti-1373	70	2	)	)	PUNCT
dti-1373	70	3	.	.	PUNCT
dti-1373	71	1	addition	addition	NOUN
dti-1373	71	2	of	of	ADP
dti-1373	71	3	increasing	increase	VERB
dti-1373	71	4	concentrations	concentration	NOUN
dti-1373	71	5	of	of	ADP
dti-1373	71	6	resveratrol	resveratrol	NOUN
dti-1373	71	7	to	to	ADP
dti-1373	71	8	pmatreated	pmatreate	VERB
dti-1373	71	9	cells	cell	NOUN
dti-1373	71	10	resulted	result	VERB
dti-1373	71	11	in	in	ADP
dti-1373	71	12	a	a	DET
dti-1373	71	13	dose	dose	NOUN
dti-1373	71	14	-	-	PUNCT
dti-1373	71	15	dependent	dependent	ADJ
dti-1373	71	16	inhibition	inhibition	NOUN
dti-1373	71	17	of	of	ADP
dti-1373	71	18	mmp-9	mmp-9	VERB
dti-1373	71	19	activity	activity	NOUN
dti-1373	71	20	(	(	PUNCT
dti-1373	71	21	ic50	ic50	PROPN
dti-1373	71	22	9.1	9.1	NUM
dti-1373	71	23	±	±	NUM
dti-1373	71	24	0.8	0.8	NUM
dti-1373	71	25	µm	µm	NOUN
dti-1373	71	26	,	,	PUNCT
dti-1373	71	27	fig	fig	NOUN
dti-1373	71	28	.	.	PUNCT
dti-1373	72	1	3b	3b	NOUN
dti-1373	72	2	and	and	CCONJ
dti-1373	72	3	c	c	NOUN
dti-1373	72	4	)	)	PUNCT
dti-1373	72	5	.	.	PUNCT
dti-1373	73	1	it	it	PRON
dti-1373	73	2	was	be	AUX
dti-1373	73	3	found	find	VERB
dti-1373	73	4	that	that	SCONJ
dti-1373	73	5	pma	pma	PROPN
dti-1373	73	6	also	also	ADV
dti-1373	73	7	increased	increase	VERB
dti-1373	73	8	mmp-9	mmp-9	NOUN
dti-1373	73	9	gene	gene	NOUN
dti-1373	73	10	expression	expression	NOUN
dti-1373	73	11	while	while	SCONJ
dti-1373	73	12	the	the	DET
dti-1373	73	13	presence	presence	NOUN
dti-1373	73	14	of	of	ADP
dti-1373	73	15	resveratrol	resveratrol	NOUN
dti-1373	73	16	inhibited	inhibit	VERB
dti-1373	73	17	this	this	DET
dti-1373	73	18	increase	increase	NOUN
dti-1373	73	19	suggesting	suggest	VERB
dti-1373	73	20	transcriptional	transcriptional	ADJ
dti-1373	73	21	regulation	regulation	NOUN
dti-1373	73	22	of	of	ADP
dti-1373	73	23	the	the	DET
dti-1373	73	24	mmp-9	mmp-9	ADJ
dti-1373	73	25	gene	gene	NOUN
dti-1373	73	26	(	(	PUNCT
dti-1373	73	27	fig	fig	NOUN
dti-1373	73	28	.	.	PUNCT
dti-1373	74	1	3d	3d	NUM
dti-1373	74	2	)	)	PUNCT
dti-1373	74	3	.	.	PUNCT
dti-1373	75	1	carcinogen	carcinogen	NOUN
dti-1373	75	2	-	-	PUNCT
dti-1373	75	3	induced	induce	VERB
dti-1373	75	4	iκb	iκb	NOUN
dti-1373	75	5	phosphorylation	phosphorylation	NOUN
dti-1373	75	6	is	be	AUX
dti-1373	75	7	inhibited	inhibit	VERB
dti-1373	75	8	by	by	ADP
dti-1373	75	9	resveratrol	resveratrol	NOUN
dti-1373	75	10	among	among	ADP
dti-1373	75	11	mmp-9	mmp-9	VERB
dti-1373	75	12	expression	expression	NOUN
dti-1373	75	13	regulators	regulator	NOUN
dti-1373	75	14	,	,	PUNCT
dti-1373	75	15	the	the	DET
dti-1373	75	16	nuclear	nuclear	ADJ
dti-1373	75	17	factor	factor	NOUN
dti-1373	75	18	-	-	PUNCT
dti-1373	75	19	kappab	kappab	NOUN
dti-1373	75	20	(	(	PUNCT
dti-1373	75	21	nf	nf	NOUN
dti-1373	75	22	-	-	PUNCT
dti-1373	75	23	κb	κb	NOUN
dti-1373	75	24	)	)	PUNCT
dti-1373	75	25	signalling	signal	VERB
dti-1373	75	26	pathway	pathway	NOUN
dti-1373	75	27	has	have	AUX
dti-1373	75	28	been	be	AUX
dti-1373	75	29	demonstrated	demonstrate	VERB
dti-1373	75	30	to	to	PART
dti-1373	75	31	link	link	VERB
dti-1373	75	32	cancer	cancer	NOUN
dti-1373	75	33	to	to	ADP
dti-1373	75	34	inflammatory	inflammatory	ADJ
dti-1373	75	35	diseases.28	diseases.28	NOUN
dti-1373	75	36	we	we	PRON
dti-1373	75	37	therefore	therefore	ADV
dti-1373	75	38	assessed	assess	VERB
dti-1373	75	39	whether	whether	SCONJ
dti-1373	75	40	this	this	DET
dti-1373	75	41	signalling	signal	VERB
dti-1373	75	42	was	be	AUX
dti-1373	75	43	activated	activate	VERB
dti-1373	75	44	upon	upon	SCONJ
dti-1373	75	45	pma	pma	NOUN
dti-1373	75	46	treatment	treatment	NOUN
dti-1373	75	47	and	and	CCONJ
dti-1373	75	48	whether	whether	SCONJ
dti-1373	75	49	it	it	PRON
dti-1373	75	50	was	be	AUX
dti-1373	75	51	reflected	reflect	VERB
dti-1373	75	52	in	in	ADP
dti-1373	75	53	ikappab	ikappab	NOUN
dti-1373	75	54	(	(	PUNCT
dti-1373	75	55	iκb	iκb	NOUN
dti-1373	75	56	)	)	PUNCT
dti-1373	75	57	degradation	degradation	NOUN
dti-1373	75	58	.	.	PUNCT
dti-1373	76	1	hbmec	hbmec	PROPN
dti-1373	76	2	were	be	AUX
dti-1373	76	3	serum	serum	NOUN
dti-1373	76	4	-	-	PUNCT
dti-1373	76	5	starved	starve	VERB
dti-1373	76	6	then	then	ADV
dti-1373	76	7	treated	treat	VERB
dti-1373	76	8	with	with	ADP
dti-1373	76	9	1	1	NUM
dti-1373	76	10	µm	µm	ADP
dti-1373	76	11	pma	pma	NOUN
dti-1373	76	12	for	for	ADP
dti-1373	76	13	up	up	ADP
dti-1373	76	14	to	to	PART
dti-1373	76	15	30	30	NUM
dti-1373	76	16	minutes	minute	NOUN
dti-1373	76	17	,	,	PUNCT
dti-1373	76	18	lysates	lysate	NOUN
dti-1373	76	19	were	be	AUX
dti-1373	76	20	isolated	isolate	VERB
dti-1373	76	21	and	and	CCONJ
dti-1373	76	22	iκb	iκb	NOUN
dti-1373	76	23	phosphorylation	phosphorylation	NOUN
dti-1373	76	24	was	be	AUX
dti-1373	76	25	assessed	assess	VERB
dti-1373	76	26	through	through	ADP
dti-1373	76	27	western	western	ADJ
dti-1373	76	28	blotting	blot	VERB
dti-1373	76	29	(	(	PUNCT
dti-1373	76	30	fig	fig	NOUN
dti-1373	76	31	.	.	PUNCT
dti-1373	77	1	4a	4a	NUM
dti-1373	77	2	,	,	PUNCT
dti-1373	77	3	upper	upper	ADJ
dti-1373	77	4	panel	panel	NOUN
dti-1373	77	5	)	)	PUNCT
dti-1373	77	6	.	.	PUNCT
dti-1373	78	1	pma	pma	PROPN
dti-1373	78	2	signalling	signal	VERB
dti-1373	78	3	led	lead	VERB
dti-1373	78	4	to	to	ADP
dti-1373	78	5	the	the	DET
dti-1373	78	6	phosphorylation	phosphorylation	NOUN
dti-1373	78	7	of	of	ADP
dti-1373	78	8	iκb	iκb	NOUN
dti-1373	78	9	peaking	peak	VERB
dti-1373	78	10	at	at	ADP
dti-1373	78	11	15	15	NUM
dti-1373	78	12	minutes.29	minutes.29	NOUN
dti-1373	78	13	resveratrol	resveratrol	NOUN
dti-1373	78	14	effect	effect	NOUN
dti-1373	78	15	on	on	ADP
dti-1373	78	16	pma	pma	NOUN
dti-1373	78	17	-	-	PUNCT
dti-1373	78	18	mediated	mediate	VERB
dti-1373	78	19	phosphorylation	phosphorylation	NOUN
dti-1373	78	20	of	of	ADP
dti-1373	78	21	iκb	iκb	NOUN
dti-1373	78	22	was	be	AUX
dti-1373	78	23	next	next	ADV
dti-1373	78	24	assessed	assess	VERB
dti-1373	78	25	in	in	ADP
dti-1373	78	26	order	order	NOUN
dti-1373	78	27	to	to	PART
dti-1373	78	28	demonstrate	demonstrate	VERB
dti-1373	78	29	whether	whether	SCONJ
dti-1373	78	30	this	this	DET
dti-1373	78	31	mechanism	mechanism	NOUN
dti-1373	78	32	contributes	contribute	VERB
dti-1373	78	33	to	to	ADP
dti-1373	78	34	the	the	DET
dti-1373	78	35	anti	anti	ADJ
dti-1373	78	36	-	-	ADJ
dti-1373	78	37	cox-2	cox-2	ADJ
dti-1373	78	38	inhibitory	inhibitory	ADJ
dti-1373	78	39	activities	activity	NOUN
dti-1373	78	40	of	of	ADP
dti-1373	78	41	resveratrol	resveratrol	NOUN
dti-1373	78	42	.	.	PUNCT
dti-1373	79	1	preincubation	preincubation	NOUN
dti-1373	79	2	with	with	ADP
dti-1373	79	3	30	30	NUM
dti-1373	79	4	µm	µm	NOUN
dti-1373	79	5	resveratrol	resveratrol	NOUN
dti-1373	79	6	followed	follow	VERB
dti-1373	79	7	by	by	ADP
dti-1373	79	8	a	a	DET
dti-1373	79	9	30	30	NUM
dti-1373	79	10	min	min	NOUN
dti-1373	79	11	pma	pma	NOUN
dti-1373	79	12	treatment	treatment	NOUN
dti-1373	79	13	led	lead	VERB
dti-1373	79	14	to	to	ADP
dti-1373	79	15	diminished	diminish	VERB
dti-1373	79	16	iκb	iκb	NOUN
dti-1373	79	17	phosphorylation	phosphorylation	NOUN
dti-1373	79	18	as	as	SCONJ
dti-1373	79	19	demonstrated	demonstrate	VERB
dti-1373	79	20	by	by	ADP
dti-1373	79	21	the	the	DET
dti-1373	79	22	decreased	decrease	VERB
dti-1373	79	23	ratios	ratio	NOUN
dti-1373	79	24	of	of	ADP
dti-1373	79	25	phosphorylated	phosphorylate	VERB
dti-1373	79	26	iκb	iκb	NOUN
dti-1373	79	27	over	over	ADP
dti-1373	79	28	gapdh	gapdh	NOUN
dti-1373	79	29	expression	expression	NOUN
dti-1373	79	30	(	(	PUNCT
dti-1373	79	31	fig	fig	NOUN
dti-1373	79	32	.	.	PUNCT
dti-1373	80	1	4b	4b	PROPN
dti-1373	80	2	)	)	PUNCT
dti-1373	80	3	.	.	PUNCT
dti-1373	81	1	20	20	NUM
dti-1373	81	2	∗	∗	NOUN
dti-1373	81	3	∗	∗	NOUN
dti-1373	81	4	∗	∗	NOUN
dti-1373	81	5	10	10	NUM
dti-1373	81	6	15	15	NUM
dti-1373	81	7	s	s	PART
dti-1373	81	8	ir	ir	NOUN
dti-1373	81	9	t1	t1	NOUN
dti-1373	81	10	g	g	PROPN
dti-1373	81	11	en	en	X
dti-1373	81	12	e	e	X
dti-1373	81	13	ex	ex	X
dti-1373	81	14	p	p	PROPN
dti-1373	81	15	re	re	ADP
dti-1373	81	16	ss	ss	PROPN
dti-1373	81	17	io	io	X
dti-1373	81	18	n	n	PROPN
dti-1373	81	19	(	(	PUNCT
dti-1373	81	20	a	a	DET
dti-1373	81	21	rb	rb	NOUN
dti-1373	81	22	.	.	PUNCT
dti-1373	82	1	l	l	NOUN
dti-1373	82	2	ev	ev	PROPN
dti-1373	82	3	el	el	PROPN
dti-1373	82	4	s	s	PROPN
dti-1373	82	5	)	)	PUNCT
dti-1373	82	6	5	5	NUM
dti-1373	82	7	0	0	NUM
dti-1373	82	8	nb	nb	INTJ
dti-1373	82	9	i	i	PRON
dti-1373	82	10	who	who	PRON
dti-1373	82	11	tumour	tumour	VERB
dti-1373	82	12	grade	grade	PROPN
dti-1373	82	13	ii	ii	PROPN
dti-1373	82	14	iii	iii	NUM
dti-1373	82	15	iv	iv	NUM
dti-1373	82	16	figure	figure	NOUN
dti-1373	82	17	1	1	NUM
dti-1373	82	18	.	.	PUNCT
dti-1373	82	19	sirt1	sirt1	NOUN
dti-1373	82	20	gene	gene	NOUN
dti-1373	82	21	expression	expression	NOUN
dti-1373	82	22	profiling	profiling	NOUN
dti-1373	82	23	in	in	ADP
dti-1373	82	24	grade	grade	NOUN
dti-1373	82	25	i	i	PROPN
dti-1373	82	26	-	-	PUNCT
dti-1373	82	27	iv	iv	NUM
dti-1373	82	28	brain	brain	NOUN
dti-1373	82	29	tumour	tumour	NOUN
dti-1373	82	30	tissues	tissue	NOUN
dti-1373	82	31	.	.	PUNCT
dti-1373	83	1	tissuescan	tissuescan	ADJ
dti-1373	83	2	™	™	ADJ
dti-1373	83	3	cancer	cancer	NOUN
dti-1373	83	4	and	and	CCONJ
dti-1373	83	5	normal	normal	ADJ
dti-1373	83	6	tissue	tissue	NOUN
dti-1373	83	7	cdna	cdna	PROPN
dti-1373	83	8	arrays	array	VERB
dti-1373	83	9	from	from	ADP
dti-1373	83	10	43	43	NUM
dti-1373	83	11	clinical	clinical	ADJ
dti-1373	83	12	samples	sample	NOUN
dti-1373	83	13	covering	cover	VERB
dti-1373	83	14	brain	brain	NOUN
dti-1373	83	15	cancer	cancer	NOUN
dti-1373	83	16	four	four	NUM
dti-1373	83	17	stages	stage	NOUN
dti-1373	83	18	and	and	CCONJ
dti-1373	83	19	normal	normal	ADJ
dti-1373	83	20	brain	brain	NOUN
dti-1373	83	21	tissues	tissue	NOUN
dti-1373	83	22	were	be	AUX
dti-1373	83	23	used	use	VERB
dti-1373	83	24	to	to	PART
dti-1373	83	25	analyze	analyze	VERB
dti-1373	83	26	differential	differential	ADJ
dti-1373	83	27	sirt1	sirt1	NOUN
dti-1373	83	28	gene	gene	NOUN
dti-1373	83	29	expression	expression	NOUN
dti-1373	83	30	.	.	PUNCT
dti-1373	84	1	tissue	tissue	NOUN
dti-1373	84	2	cdnas	cdna	NOUN
dti-1373	84	3	of	of	ADP
dti-1373	84	4	each	each	DET
dti-1373	84	5	array	array	NOUN
dti-1373	84	6	are	be	AUX
dti-1373	84	7	synthesized	synthesize	VERB
dti-1373	84	8	from	from	ADP
dti-1373	84	9	high	high	ADJ
dti-1373	84	10	quality	quality	NOUN
dti-1373	84	11	total	total	ADJ
dti-1373	84	12	rnas	rna	NOUN
dti-1373	84	13	of	of	ADP
dti-1373	84	14	pathologistverified	pathologistverified	ADJ
dti-1373	84	15	tissues	tissue	NOUN
dti-1373	84	16	,	,	PUNCT
dti-1373	84	17	normalized	normalize	VERB
dti-1373	84	18	and	and	CCONJ
dti-1373	84	19	validated	validate	VERB
dti-1373	84	20	with	with	ADP
dti-1373	84	21	β	β	NOUN
dti-1373	84	22	-	-	NOUN
dti-1373	84	23	actin	actin	NOUN
dti-1373	84	24	and	and	CCONJ
dti-1373	84	25	provided	provide	VERB
dti-1373	84	26	with	with	ADP
dti-1373	84	27	clinical	clinical	ADJ
dti-1373	84	28	information	information	NOUN
dti-1373	84	29	for	for	ADP
dti-1373	84	30	2	2	NUM
dti-1373	84	31	normal	normal	ADJ
dti-1373	84	32	brain	brain	NOUN
dti-1373	84	33	,	,	PUNCT
dti-1373	84	34	18	18	NUM
dti-1373	84	35	who	who	PRON
dti-1373	84	36	grade	grade	VERB
dti-1373	84	37	i	i	PRON
dti-1373	84	38	,	,	PUNCT
dti-1373	84	39	11	11	NUM
dti-1373	84	40	who	who	PRON
dti-1373	84	41	grade	grade	PROPN
dti-1373	84	42	ii	ii	PROPN
dti-1373	84	43	,	,	PUNCT
dti-1373	84	44	10	10	NUM
dti-1373	84	45	who	who	PRON
dti-1373	84	46	grade	grade	NOUN
dti-1373	84	47	iii	iii	PROPN
dti-1373	84	48	,	,	PUNCT
dti-1373	84	49	and	and	CCONJ
dti-1373	84	50	2	2	NUM
dti-1373	84	51	who	who	PRON
dti-1373	84	52	grade	grade	NOUN
dti-1373	84	53	iv	iv	NUM
dti-1373	84	54	brain	brain	NOUN
dti-1373	84	55	tumours	tumours	NOUN
dti-1373	84	56	.	.	PUNCT
dti-1373	85	1	abbreviation	abbreviation	NOUN
dti-1373	85	2	:	:	PUNCT
dti-1373	85	3	nb	nb	INTJ
dti-1373	85	4	,	,	PUNCT
dti-1373	85	5	normal	normal	ADJ
dti-1373	85	6	brain	brain	NOUN
dti-1373	85	7	tissue	tissue	NOUN
dti-1373	85	8	.	.	PUNCT
dti-1373	86	1	http://www.la-press.com	http://www.la-press.com	X
dti-1373	87	1	sirt1	sirt1	NOUN
dti-1373	87	2	expression	expression	NOUN
dti-1373	87	3	in	in	ADP
dti-1373	87	4	inflammatory	inflammatory	ADJ
dti-1373	87	5	cerebral	cerebral	ADJ
dti-1373	87	6	endothelium	endothelium	NOUN
dti-1373	87	7	drug	drug	NOUN
dti-1373	87	8	target	target	NOUN
dti-1373	87	9	insights	insight	NOUN
dti-1373	87	10	2012:6	2012:6	NUM
dti-1373	87	11	5	5	NUM
dti-1373	87	12	sirt1	sirt1	NOUN
dti-1373	87	13	contributes	contribute	VERB
dti-1373	87	14	to	to	ADP
dti-1373	87	15	the	the	DET
dti-1373	87	16	resveratrol	resveratrol	NOUN
dti-1373	87	17	inhibitory	inhibitory	ADJ
dti-1373	87	18	effect	effect	NOUN
dti-1373	87	19	of	of	ADP
dti-1373	87	20	pma	pma	NOUN
dti-1373	87	21	-	-	PUNCT
dti-1373	87	22	induced	induce	VERB
dti-1373	87	23	iκb	iκb	NOUN
dti-1373	87	24	phosphorylation	phosphorylation	NOUN
dti-1373	87	25	sirt1	sirt1	NOUN
dti-1373	87	26	is	be	AUX
dti-1373	87	27	,	,	PUNCT
dti-1373	87	28	among	among	ADP
dti-1373	87	29	the	the	DET
dti-1373	87	30	sirtuins	sirtuin	NOUN
dti-1373	87	31	family	family	NOUN
dti-1373	87	32	,	,	PUNCT
dti-1373	87	33	documented	document	VERB
dti-1373	87	34	to	to	PART
dti-1373	87	35	be	be	AUX
dti-1373	87	36	targeted	target	VERB
dti-1373	87	37	by	by	ADP
dti-1373	87	38	resveratrol	resveratrol	NOUN
dti-1373	87	39	.	.	PUNCT
dti-1373	88	1	in	in	ADP
dti-1373	88	2	order	order	NOUN
dti-1373	88	3	to	to	PART
dti-1373	88	4	assess	assess	VERB
dti-1373	88	5	the	the	DET
dti-1373	88	6	contribution	contribution	NOUN
dti-1373	88	7	of	of	ADP
dti-1373	88	8	sirt1	sirt1	NOUN
dti-1373	88	9	in	in	ADP
dti-1373	88	10	the	the	DET
dti-1373	88	11	resveratrol	resveratrol	NOUN
dti-1373	88	12	inhibition	inhibition	NOUN
dti-1373	88	13	of	of	ADP
dti-1373	88	14	nf	nf	NOUN
dti-1373	88	15	-	-	PUNCT
dti-1373	88	16	κb	κb	NOUN
dti-1373	88	17	,	,	PUNCT
dti-1373	88	18	hbmec	hbmec	PROPN
dti-1373	88	19	were	be	AUX
dti-1373	88	20	next	next	ADV
dti-1373	88	21	transiently	transiently	ADV
dti-1373	88	22	transfected	transfecte	VERB
dti-1373	88	23	with	with	ADP
dti-1373	88	24	a	a	DET
dti-1373	88	25	scrambled	scramble	VERB
dti-1373	88	26	sirna	sirna	PROPN
dti-1373	88	27	sequence	sequence	NOUN
dti-1373	88	28	(	(	PUNCT
dti-1373	88	29	mock	mock	ADJ
dti-1373	88	30	)	)	PUNCT
dti-1373	88	31	or	or	CCONJ
dti-1373	88	32	an	an	DET
dti-1373	88	33	sirna	sirna	PROPN
dti-1373	88	34	designed	design	VERB
dti-1373	88	35	to	to	PART
dti-1373	88	36	downregulate	downregulate	VERB
dti-1373	88	37	sirt1	sirt1	PROPN
dti-1373	88	38	(	(	PUNCT
dti-1373	88	39	sisirt1	sisirt1	NOUN
dti-1373	88	40	)	)	PUNCT
dti-1373	88	41	gene	gene	NOUN
dti-1373	88	42	expression	expression	NOUN
dti-1373	88	43	.	.	PUNCT
dti-1373	89	1	preincubation	preincubation	NOUN
dti-1373	89	2	with	with	ADP
dti-1373	89	3	30	30	NUM
dti-1373	89	4	µm	µm	NOUN
dti-1373	89	5	resveratrol	resveratrol	NOUN
dti-1373	89	6	followed	follow	VERB
dti-1373	89	7	by	by	ADP
dti-1373	89	8	a	a	DET
dti-1373	89	9	30	30	NUM
dti-1373	89	10	min	min	NOUN
dti-1373	89	11	pma	pma	NOUN
dti-1373	89	12	treatment	treatment	NOUN
dti-1373	89	13	was	be	AUX
dti-1373	89	14	performed	perform	VERB
dti-1373	89	15	c	c	PROPN
dti-1373	89	16	b	b	PROPN
dti-1373	89	17	a	a	DET
dti-1373	89	18	vehicle	vehicle	NOUN
dti-1373	89	19	pma	pma	NOUN
dti-1373	89	20	(	(	PUNCT
dti-1373	89	21	1	1	NUM
dti-1373	89	22	µm	µm	NOUN
dti-1373	89	23	)	)	PUNCT
dti-1373	89	24	resveratrol	resveratrol	NOUN
dti-1373	89	25	(	(	PUNCT
dti-1373	89	26	µm	µm	NOUN
dti-1373	89	27	)	)	PUNCT
dti-1373	89	28	resveratrol	resveratrol	NOUN
dti-1373	89	29	vehicle	vehicle	NOUN
dti-1373	89	30	pma	pma	NOUN
dti-1373	89	31	resveratrol	resveratrol	NOUN
dti-1373	89	32	(	(	PUNCT
dti-1373	89	33	µm	µm	NOUN
dti-1373	89	34	)	)	PUNCT
dti-1373	89	35	cox-2	cox-2	ADV
dti-1373	89	36	ns	ns	NUM
dti-1373	89	37	gapdh	gapdh	NOUN
dti-1373	89	38	0	0	NUM
dti-1373	89	39	0	0	NUM
dti-1373	89	40	5	5	NUM
dti-1373	89	41	10	10	NUM
dti-1373	89	42	25	25	NUM
dti-1373	89	43	50	50	NUM
dti-1373	89	44	100100	100100	NUM
dti-1373	89	45	100	100	NUM
dti-1373	89	46	80	80	NUM
dti-1373	89	47	60	60	NUM
dti-1373	89	48	40	40	NUM
dti-1373	89	49	20	20	NUM
dti-1373	89	50	0	0	NUM
dti-1373	89	51	0	0	NUM
dti-1373	89	52	20	20	NUM
dti-1373	89	53	40	40	NUM
dti-1373	89	54	60	60	NUM
dti-1373	89	55	80	80	NUM
dti-1373	89	56	∗	∗	NOUN
dti-1373	89	57	100	100	NUM
dti-1373	89	58	120	120	NUM
dti-1373	89	59	100	100	NUM
dti-1373	89	60	80	80	NUM
dti-1373	89	61	60	60	NUM
dti-1373	89	62	40	40	NUM
dti-1373	89	63	20	20	NUM
dti-1373	89	64	0	0	NUM
dti-1373	89	65	−	−	NOUN
dti-1373	90	1	+	+	CCONJ
dti-1373	90	2	−	−	PROPN
dti-1373	91	1	+	+	CCONJ
dti-1373	91	2	120	120	NUM
dti-1373	91	3	c	c	NOUN
dti-1373	91	4	o	o	NOUN
dti-1373	91	5	x	x	X
dti-1373	92	1	-2	-2	NOUN
dti-1373	92	2	g	g	PROPN
dti-1373	92	3	en	en	X
dti-1373	92	4	e	e	X
dti-1373	92	5	ex	ex	X
dti-1373	92	6	p	p	PROPN
dti-1373	92	7	re	re	ADP
dti-1373	92	8	ss	ss	PROPN
dti-1373	92	9	io	io	X
dti-1373	92	10	n	n	PROPN
dti-1373	92	11	(	(	PUNCT
dti-1373	92	12	x	x	X
dti-1373	92	13	-f	-f	NUM
dti-1373	93	1	o	o	INTJ
dti-1373	93	2	ld	ld	X
dti-1373	93	3	o	o	X
dti-1373	93	4	ve	ve	VERB
dti-1373	93	5	r	r	NOUN
dti-1373	93	6	c	c	NOUN
dti-1373	93	7	tr	tr	NOUN
dti-1373	93	8	l	l	NOUN
dti-1373	93	9	)	)	PUNCT
dti-1373	94	1	c	c	NOUN
dti-1373	95	1	o	o	NOUN
dti-1373	95	2	x	x	X
dti-1373	96	1	-2	-2	INTJ
dti-1373	96	2	/g	/g	PUNCT
dti-1373	96	3	a	a	DET
dti-1373	96	4	p	p	X
dti-1373	96	5	d	d	X
dti-1373	96	6	h	h	NOUN
dti-1373	97	1	(	(	PUNCT
dti-1373	97	2	%	%	INTJ
dti-1373	97	3	o	o	X
dti-1373	98	1	f	f	X
dti-1373	98	2	p	p	X
dti-1373	98	3	m	m	PROPN
dti-1373	98	4	a	a	DET
dti-1373	98	5	)	)	PUNCT
dti-1373	98	6	figure	figure	NOUN
dti-1373	98	7	2	2	NUM
dti-1373	98	8	.	.	PUNCT
dti-1373	99	1	resveratrol	resveratrol	NOUN
dti-1373	99	2	dose	dose	NOUN
dti-1373	99	3	-	-	PUNCT
dti-1373	99	4	dependent	dependent	ADJ
dti-1373	99	5	inhibition	inhibition	NOUN
dti-1373	99	6	of	of	ADP
dti-1373	99	7	carcinogen	carcinogen	NOUN
dti-1373	99	8	-	-	PUNCT
dti-1373	99	9	induced	induce	VERB
dti-1373	99	10	cox-2	cox-2	ADJ
dti-1373	99	11	protein	protein	NOUN
dti-1373	99	12	and	and	CCONJ
dti-1373	99	13	gene	gene	NOUN
dti-1373	99	14	expression	expression	NOUN
dti-1373	99	15	.	.	PUNCT
dti-1373	100	1	(	(	PUNCT
dti-1373	100	2	a	a	X
dti-1373	100	3	)	)	PUNCT
dti-1373	100	4	hbmec	hbmec	NOUN
dti-1373	100	5	were	be	AUX
dti-1373	100	6	serum	serum	NOUN
dti-1373	100	7	-	-	PUNCT
dti-1373	100	8	starved	starve	VERB
dti-1373	100	9	in	in	ADP
dti-1373	100	10	the	the	DET
dti-1373	100	11	presence	presence	NOUN
dti-1373	100	12	of	of	ADP
dti-1373	100	13	various	various	ADJ
dti-1373	100	14	concentrations	concentration	NOUN
dti-1373	100	15	of	of	ADP
dti-1373	100	16	resveratrol	resveratrol	NOUN
dti-1373	100	17	and	and	CCONJ
dti-1373	100	18	in	in	ADP
dti-1373	100	19	combination	combination	NOUN
dti-1373	100	20	with	with	ADP
dti-1373	100	21	vehicle	vehicle	NOUN
dti-1373	100	22	or	or	CCONJ
dti-1373	100	23	1	1	NUM
dti-1373	100	24	µm	µm	ADP
dti-1373	100	25	pma	pma	NOUN
dti-1373	100	26	for	for	ADP
dti-1373	100	27	18	18	NUM
dti-1373	100	28	hours	hour	NOUN
dti-1373	100	29	.	.	PUNCT
dti-1373	101	1	lysates	lysate	NOUN
dti-1373	101	2	were	be	AUX
dti-1373	101	3	isolated	isolate	VERB
dti-1373	101	4	,	,	PUNCT
dti-1373	101	5	electrophoresed	electrophorese	VERB
dti-1373	101	6	via	via	ADP
dti-1373	101	7	sds	sds	PROPN
dti-1373	101	8	-	-	PUNCT
dti-1373	101	9	page	page	NOUN
dti-1373	101	10	,	,	PUNCT
dti-1373	101	11	and	and	CCONJ
dti-1373	101	12	immunodetection	immunodetection	NOUN
dti-1373	101	13	of	of	ADP
dti-1373	101	14	cox-2	cox-2	NOUN
dti-1373	101	15	and	and	CCONJ
dti-1373	101	16	gapdh	gapdh	NOUN
dti-1373	101	17	performed	perform	VERB
dti-1373	101	18	as	as	SCONJ
dti-1373	101	19	described	describe	VERB
dti-1373	101	20	in	in	ADP
dti-1373	101	21	the	the	DET
dti-1373	101	22	methods	method	NOUN
dti-1373	101	23	section	section	NOUN
dti-1373	101	24	(	(	PUNCT
dti-1373	101	25	ns	ns	INTJ
dti-1373	101	26	,	,	PUNCT
dti-1373	101	27	non	non	X
dti-1373	101	28	specific	specific	ADJ
dti-1373	101	29	immunoreactivity	immunoreactivity	NOUN
dti-1373	101	30	)	)	PUNCT
dti-1373	101	31	.	.	PUNCT
dti-1373	102	1	(	(	PUNCT
dti-1373	102	2	b	b	X
dti-1373	102	3	)	)	PUNCT
dti-1373	102	4	scanning	scan	VERB
dti-1373	102	5	densitometry	densitometry	NOUN
dti-1373	102	6	of	of	ADP
dti-1373	102	7	cox-2	cox-2	ADJ
dti-1373	102	8	expression	expression	NOUN
dti-1373	102	9	was	be	AUX
dti-1373	102	10	only	only	ADV
dti-1373	102	11	performed	perform	VERB
dti-1373	102	12	in	in	ADP
dti-1373	102	13	pma	pma	PROPN
dti-1373	102	14	-	-	PUNCT
dti-1373	102	15	treated	treat	VERB
dti-1373	102	16	cells	cell	NOUN
dti-1373	102	17	since	since	SCONJ
dti-1373	102	18	no	no	DET
dti-1373	102	19	cox-2	cox-2	NOUN
dti-1373	102	20	was	be	AUX
dti-1373	102	21	detectable	detectable	ADJ
dti-1373	102	22	in	in	ADP
dti-1373	102	23	vehicle	vehicle	NOUN
dti-1373	102	24	-	-	PUNCT
dti-1373	102	25	treated	treat	VERB
dti-1373	102	26	hbmec	hbmec	NOUN
dti-1373	102	27	.	.	PUNCT
dti-1373	103	1	densitometric	densitometric	ADJ
dti-1373	103	2	data	datum	NOUN
dti-1373	103	3	of	of	ADP
dti-1373	103	4	a	a	DET
dti-1373	103	5	representative	representative	ADJ
dti-1373	103	6	blot	blot	NOUN
dti-1373	103	7	is	be	AUX
dti-1373	103	8	shown	show	VERB
dti-1373	103	9	out	out	ADP
dti-1373	103	10	of	of	ADP
dti-1373	103	11	three	three	NUM
dti-1373	103	12	independent	independent	ADJ
dti-1373	103	13	experiments	experiment	NOUN
dti-1373	103	14	.	.	PUNCT
dti-1373	104	1	(	(	PUNCT
dti-1373	104	2	c	c	X
dti-1373	104	3	)	)	PUNCT
dti-1373	104	4	total	total	ADJ
dti-1373	104	5	rna	rna	NOUN
dti-1373	104	6	isolation	isolation	NOUN
dti-1373	104	7	,	,	PUNCT
dti-1373	104	8	rt	rt	NOUN
dti-1373	104	9	-	-	PUNCT
dti-1373	104	10	pcr	pcr	NOUN
dti-1373	104	11	,	,	PUNCT
dti-1373	104	12	and	and	CCONJ
dti-1373	104	13	qpcr	qpcr	ADV
dti-1373	104	14	were	be	AUX
dti-1373	104	15	performed	perform	VERB
dti-1373	104	16	as	as	SCONJ
dti-1373	104	17	described	describe	VERB
dti-1373	104	18	in	in	ADP
dti-1373	104	19	the	the	DET
dti-1373	104	20	methods	method	NOUN
dti-1373	104	21	section	section	NOUN
dti-1373	104	22	to	to	PART
dti-1373	104	23	assess	assess	VERB
dti-1373	104	24	cox-2	cox-2	ADJ
dti-1373	104	25	gene	gene	NOUN
dti-1373	104	26	expression	expression	NOUN
dti-1373	104	27	in	in	ADP
dti-1373	104	28	the	the	DET
dti-1373	104	29	above	above	ADV
dti-1373	104	30	-	-	PUNCT
dti-1373	104	31	described	describe	VERB
dti-1373	104	32	conditions	condition	NOUN
dti-1373	104	33	.	.	PUNCT
dti-1373	105	1	(	(	PUNCT
dti-1373	105	2	pma	pma	NOUN
dti-1373	105	3	=	=	NOUN
dti-1373	105	4	1	1	NUM
dti-1373	105	5	µm	µm	NUM
dti-1373	105	6	;	;	PUNCT
dti-1373	105	7	resveratrol	resveratrol	NOUN
dti-1373	105	8	=	=	SYM
dti-1373	105	9	30	30	NUM
dti-1373	105	10	µm	µm	NOUN
dti-1373	105	11	)	)	PUNCT
dti-1373	105	12	.	.	PUNCT
dti-1373	106	1	notes	note	NOUN
dti-1373	106	2	:	:	PUNCT
dti-1373	106	3	data	datum	NOUN
dti-1373	106	4	are	be	AUX
dti-1373	106	5	representative	representative	NOUN
dti-1373	106	6	of	of	ADP
dti-1373	106	7	three	three	NUM
dti-1373	106	8	independent	independent	ADJ
dti-1373	106	9	qpcr	qpcr	ADJ
dti-1373	106	10	experiments	experiment	NOUN
dti-1373	106	11	.	.	PUNCT
dti-1373	107	1	probability	probability	NOUN
dti-1373	107	2	values	value	NOUN
dti-1373	107	3	of	of	ADP
dti-1373	107	4	less	less	ADJ
dti-1373	107	5	than	than	ADP
dti-1373	107	6	0.05	0.05	NUM
dti-1373	107	7	were	be	AUX
dti-1373	107	8	considered	consider	VERB
dti-1373	107	9	significant	significant	ADJ
dti-1373	107	10	,	,	PUNCT
dti-1373	107	11	and	and	CCONJ
dti-1373	107	12	an	an	DET
dti-1373	107	13	asterisk	asterisk	NOUN
dti-1373	107	14	(	(	PUNCT
dti-1373	107	15	*	*	PUNCT
dti-1373	107	16	)	)	PUNCT
dti-1373	107	17	identifies	identify	VERB
dti-1373	107	18	such	such	ADJ
dti-1373	107	19	significance	significance	NOUN
dti-1373	107	20	to	to	ADP
dti-1373	107	21	the	the	DET
dti-1373	107	22	respective	respective	ADJ
dti-1373	107	23	pma	pma	NOUN
dti-1373	107	24	treatment	treatment	NOUN
dti-1373	107	25	.	.	PUNCT
dti-1373	108	1	http://www.la-press.com	http://www.la-press.com	X
dti-1373	108	2	annabi	annabi	PROPN
dti-1373	108	3	et	et	PROPN
dti-1373	108	4	al	al	PROPN
dti-1373	108	5	6	6	NUM
dti-1373	108	6	drug	drug	NOUN
dti-1373	108	7	target	target	NOUN
dti-1373	108	8	insights	insight	NOUN
dti-1373	108	9	2012:6	2012:6	NUM
dti-1373	108	10	in	in	ADP
dti-1373	108	11	mock	mock	ADJ
dti-1373	108	12	and	and	CCONJ
dti-1373	108	13	in	in	ADP
dti-1373	108	14	sisirt1	sisirt1	NOUN
dti-1373	108	15	-	-	PUNCT
dti-1373	108	16	transfected	transfecte	VERB
dti-1373	108	17	cells	cell	NOUN
dti-1373	108	18	.	.	PUNCT
dti-1373	109	1	lysates	lysate	NOUN
dti-1373	109	2	were	be	AUX
dti-1373	109	3	isolated	isolate	VERB
dti-1373	109	4	,	,	PUNCT
dti-1373	109	5	and	and	CCONJ
dti-1373	109	6	gapdh	gapdh	NOUN
dti-1373	109	7	or	or	CCONJ
dti-1373	109	8	iκb	iκb	NOUN
dti-1373	109	9	phosphorylation	phosphorylation	NOUN
dti-1373	109	10	assessed	assess	VERB
dti-1373	109	11	through	through	ADP
dti-1373	109	12	western	western	ADJ
dti-1373	109	13	blotting	blot	VERB
dti-1373	109	14	(	(	PUNCT
dti-1373	109	15	fig	fig	NOUN
dti-1373	109	16	.	.	PUNCT
dti-1373	110	1	5a	5a	NUM
dti-1373	110	2	,	,	PUNCT
dti-1373	110	3	upper	upper	ADJ
dti-1373	110	4	panel	panel	NOUN
dti-1373	110	5	)	)	PUNCT
dti-1373	110	6	.	.	PUNCT
dti-1373	111	1	while	while	SCONJ
dti-1373	111	2	∼90	∼90	NOUN
dti-1373	111	3	%	%	NOUN
dti-1373	111	4	inhibition	inhibition	NOUN
dti-1373	111	5	in	in	ADP
dti-1373	111	6	sirt1	sirt1	NOUN
dti-1373	111	7	gene	gene	NOUN
dti-1373	111	8	expression	expression	NOUN
dti-1373	111	9	was	be	AUX
dti-1373	111	10	observed	observe	VERB
dti-1373	111	11	in	in	ADP
dti-1373	111	12	sisirt1	sisirt1	NOUN
dti-1373	111	13	-	-	PUNCT
dti-1373	111	14	transfected	transfecte	VERB
dti-1373	111	15	cells	cell	NOUN
dti-1373	111	16	(	(	PUNCT
dti-1373	111	17	fig	fig	NOUN
dti-1373	111	18	.	.	PUNCT
dti-1373	112	1	5b	5b	NUM
dti-1373	112	2	)	)	PUNCT
dti-1373	113	1	,	,	PUNCT
dti-1373	113	2	we	we	PRON
dti-1373	113	3	found	find	VERB
dti-1373	113	4	that	that	SCONJ
dti-1373	113	5	resveratrol	resveratrol	NOUN
dti-1373	113	6	inhibitory	inhibitory	ADJ
dti-1373	113	7	potential	potential	NOUN
dti-1373	113	8	was	be	AUX
dti-1373	113	9	significantly	significantly	ADV
dti-1373	113	10	diminished	diminish	VERB
dti-1373	113	11	in	in	ADP
dti-1373	113	12	those	those	DET
dti-1373	113	13	cells	cell	NOUN
dti-1373	113	14	which	which	PRON
dti-1373	113	15	had	have	VERB
dti-1373	113	16	sirt1	sirt1	NOUN
dti-1373	113	17	expression	expression	NOUN
dti-1373	113	18	silenced	silence	VERB
dti-1373	113	19	(	(	PUNCT
dti-1373	113	20	fig	fig	NOUN
dti-1373	113	21	.	.	PUNCT
dti-1373	114	1	5c	5c	NUM
dti-1373	114	2	,	,	PUNCT
dti-1373	114	3	closed	close	VERB
dti-1373	114	4	circles	circle	NOUN
dti-1373	114	5	)	)	PUNCT
dti-1373	115	1	in	in	ADP
dti-1373	115	2	comparison	comparison	NOUN
dti-1373	115	3	to	to	ADP
dti-1373	115	4	mock	mock	ADV
dti-1373	115	5	-	-	PUNCT
dti-1373	115	6	transfected	transfecte	VERB
dti-1373	115	7	cells	cell	NOUN
dti-1373	115	8	(	(	PUNCT
dti-1373	115	9	fig	fig	NOUN
dti-1373	115	10	.	.	PUNCT
dti-1373	115	11	5c	5c	NOUN
dti-1373	115	12	,	,	PUNCT
dti-1373	115	13	open	open	ADJ
dti-1373	115	14	circles	circle	NOUN
dti-1373	115	15	)	)	PUNCT
dti-1373	115	16	.	.	PUNCT
dti-1373	116	1	pma	pma	NOUN
dti-1373	116	2	treatment	treatment	NOUN
dti-1373	116	3	by	by	ADP
dti-1373	116	4	itself	itself	PRON
dti-1373	116	5	did	do	AUX
dti-1373	116	6	not	not	PART
dti-1373	116	7	affect	affect	VERB
dti-1373	116	8	sirt1	sirt1	NOUN
dti-1373	116	9	gene	gene	NOUN
dti-1373	116	10	expression	expression	NOUN
dti-1373	116	11	(	(	PUNCT
dti-1373	116	12	not	not	PART
dti-1373	116	13	shown	show	VERB
dti-1373	116	14	)	)	PUNCT
dti-1373	116	15	.	.	PUNCT
dti-1373	117	1	this	this	PRON
dti-1373	117	2	suggests	suggest	VERB
dti-1373	117	3	that	that	SCONJ
dti-1373	117	4	sirt1	sirt1	NOUN
dti-1373	117	5	is	be	AUX
dti-1373	117	6	indeed	indeed	ADV
dti-1373	117	7	important	important	ADJ
dti-1373	117	8	in	in	ADP
dti-1373	117	9	the	the	DET
dti-1373	117	10	inhibitory	inhibitory	ADJ
dti-1373	117	11	potential	potential	NOUN
dti-1373	117	12	of	of	ADP
dti-1373	117	13	resveratrol	resveratrol	NOUN
dti-1373	117	14	against	against	ADP
dti-1373	117	15	pma	pma	NOUN
dti-1373	117	16	-	-	PUNCT
dti-1373	117	17	mediated	mediate	VERB
dti-1373	117	18	nf	nf	ADJ
dti-1373	117	19	-	-	PUNCT
dti-1373	117	20	κb	κb	NOUN
dti-1373	117	21	signaling	signal	VERB
dti-1373	117	22	pathway	pathway	NOUN
dti-1373	117	23	.	.	PUNCT
dti-1373	118	1	sirt1	sirt1	ADJ
dti-1373	118	2	-	-	ADJ
dti-1373	118	3	independent	independent	ADJ
dti-1373	118	4	inhibition	inhibition	NOUN
dti-1373	118	5	by	by	ADP
dti-1373	118	6	resveratrol	resveratrol	NOUN
dti-1373	118	7	of	of	ADP
dti-1373	118	8	pma	pma	NOUN
dti-1373	118	9	-	-	PUNCT
dti-1373	118	10	induced	induce	VERB
dti-1373	118	11	cox-2	cox-2	ADJ
dti-1373	118	12	expression	expression	NOUN
dti-1373	118	13	and	and	CCONJ
dti-1373	118	14	of	of	ADP
dti-1373	118	15	pma	pma	NOUN
dti-1373	118	16	-	-	PUNCT
dti-1373	118	17	induced	induce	VERB
dti-1373	118	18	mmp-9	mmp-9	NOUN
dti-1373	118	19	secretion	secretion	NOUN
dti-1373	118	20	whether	whether	SCONJ
dti-1373	118	21	sirt1	sirt1	NOUN
dti-1373	118	22	serves	serve	VERB
dti-1373	118	23	as	as	ADP
dti-1373	118	24	an	an	DET
dti-1373	118	25	intermediate	intermediate	ADJ
dti-1373	118	26	in	in	ADP
dti-1373	118	27	the	the	DET
dti-1373	118	28	resveratrol	resveratrol	NOUN
dti-1373	118	29	inhibitory	inhibitory	ADJ
dti-1373	118	30	potential	potential	NOUN
dti-1373	118	31	was	be	AUX
dti-1373	118	32	next	next	ADV
dti-1373	118	33	investigated	investigate	VERB
dti-1373	118	34	on	on	ADP
dti-1373	118	35	pma	pma	NOUN
dti-1373	118	36	-	-	PUNCT
dti-1373	118	37	treated	treat	VERB
dti-1373	118	38	cells	cell	NOUN
dti-1373	118	39	for	for	ADP
dti-1373	118	40	cox-2	cox-2	NUM
dti-1373	118	41	and	and	CCONJ
dti-1373	118	42	mmp-9	mmp-9	NOUN
dti-1373	118	43	expression	expression	NOUN
dti-1373	118	44	.	.	PUNCT
dti-1373	119	1	as	as	SCONJ
dti-1373	119	2	described	describe	VERB
dti-1373	119	3	above	above	ADV
dti-1373	119	4	,	,	PUNCT
dti-1373	119	5	serum	serum	NOUN
dti-1373	119	6	-	-	PUNCT
dti-1373	119	7	starved	starve	VERB
dti-1373	119	8	mock	mock	ADJ
dti-1373	119	9	and	and	CCONJ
dti-1373	119	10	sisirt1	sisirt1	NOUN
dti-1373	119	11	-	-	PUNCT
dti-1373	119	12	transfected	transfecte	VERB
dti-1373	119	13	hbmec	hbmec	NOUN
dti-1373	119	14	were	be	AUX
dti-1373	119	15	treated	treat	VERB
dti-1373	119	16	with	with	ADP
dti-1373	119	17	pma	pma	NOUN
dti-1373	119	18	,	,	PUNCT
dti-1373	119	19	resveratrol	resveratrol	NOUN
dti-1373	119	20	or	or	CCONJ
dti-1373	119	21	a	a	DET
dti-1373	119	22	combination	combination	NOUN
dti-1373	119	23	of	of	ADP
dti-1373	119	24	both	both	DET
dti-1373	119	25	agents	agent	NOUN
dti-1373	119	26	.	.	PUNCT
dti-1373	120	1	while	while	SCONJ
dti-1373	120	2	resveratrol	resveratrol	NOUN
dti-1373	120	3	efficiently	efficiently	ADV
dti-1373	120	4	inhibited	inhibit	VERB
dti-1373	120	5	both	both	DET
dti-1373	120	6	pma	pma	NOUN
dti-1373	120	7	-	-	PUNCT
dti-1373	120	8	induced	induced	ADJ
dti-1373	120	9	cox-2	cox-2	ADJ
dti-1373	120	10	(	(	PUNCT
dti-1373	120	11	fig	fig	NOUN
dti-1373	120	12	.	.	PUNCT
dti-1373	120	13	6a	6a	NOUN
dti-1373	120	14	)	)	PUNCT
dti-1373	120	15	and	and	CCONJ
dti-1373	120	16	mmp-9	mmp-9	NOUN
dti-1373	120	17	(	(	PUNCT
dti-1373	120	18	fig	fig	NOUN
dti-1373	120	19	.	.	PUNCT
dti-1373	120	20	6b	6b	NOUN
dti-1373	120	21	)	)	PUNCT
dti-1373	120	22	,	,	PUNCT
dti-1373	120	23	silencing	silence	VERB
dti-1373	120	24	of	of	ADP
dti-1373	120	25	sirt1	sirt1	NOUN
dti-1373	120	26	did	do	AUX
dti-1373	120	27	not	not	PART
dti-1373	120	28	lead	lead	VERB
dti-1373	120	29	to	to	ADP
dti-1373	120	30	any	any	DET
dti-1373	120	31	reversal	reversal	NOUN
dti-1373	120	32	of	of	ADP
dti-1373	120	33	effect	effect	NOUN
dti-1373	120	34	as	as	SCONJ
dti-1373	120	35	resveratrol	resveratrol	NOUN
dti-1373	120	36	still	still	ADV
dti-1373	120	37	efficiently	efficiently	ADV
dti-1373	120	38	inhibited	inhibit	VERB
dti-1373	120	39	cox-2	cox-2	ADV
dti-1373	120	40	and	and	CCONJ
dti-1373	120	41	mmp-9	mmp-9	NOUN
dti-1373	120	42	.	.	PUNCT
dti-1373	121	1	this	this	PRON
dti-1373	121	2	suggests	suggest	VERB
dti-1373	121	3	that	that	SCONJ
dti-1373	121	4	resveratrol	resveratrol	NOUN
dti-1373	121	5	inhibition	inhibition	NOUN
dti-1373	121	6	of	of	ADP
dti-1373	121	7	pma	pma	NOUN
dti-1373	121	8	-	-	PUNCT
dti-1373	121	9	induced	induced	ADJ
dti-1373	121	10	cox-2	cox-2	NOUN
dti-1373	121	11	and	and	CCONJ
dti-1373	121	12	mmp-9	mmp-9	NOUN
dti-1373	121	13	is	be	AUX
dti-1373	121	14	a	a	DET
dti-1373	121	15	sirt1	sirt1	NOUN
dti-1373	121	16	independent	independent	ADJ
dti-1373	121	17	event	event	NOUN
dti-1373	121	18	.	.	PUNCT
dti-1373	122	1	discussion	discussion	NOUN
dti-1373	122	2	the	the	DET
dti-1373	122	3	adaptive	adaptive	ADJ
dti-1373	122	4	mechanisms	mechanism	NOUN
dti-1373	122	5	responsible	responsible	ADJ
dti-1373	122	6	for	for	ADP
dti-1373	122	7	ec	ec	PROPN
dti-1373	122	8	metabolic	metabolic	NOUN
dti-1373	122	9	adaptation	adaptation	NOUN
dti-1373	122	10	and	and	CCONJ
dti-1373	122	11	survival	survival	NOUN
dti-1373	122	12	under	under	ADP
dti-1373	122	13	procarcinogenic	procarcinogenic	ADJ
dti-1373	122	14	stimulation	stimulation	NOUN
dti-1373	122	15	,	,	PUNCT
dti-1373	122	16	or	or	CCONJ
dti-1373	122	17	as	as	SCONJ
dti-1373	122	18	encountered	encounter	VERB
dti-1373	122	19	within	within	ADP
dti-1373	122	20	a	a	DET
dti-1373	122	21	tumour	tumour	NOUN
dti-1373	122	22	microenvironment	microenvironment	NOUN
dti-1373	122	23	,	,	PUNCT
dti-1373	122	24	still	still	ADV
dti-1373	122	25	remain	remain	AUX
dti-1373	122	26	poorly	poorly	ADV
dti-1373	122	27	documented	document	VERB
dti-1373	122	28	.	.	PUNCT
dti-1373	123	1	while	while	SCONJ
dti-1373	123	2	interest	interest	NOUN
dti-1373	123	3	has	have	AUX
dti-1373	123	4	been	be	AUX
dti-1373	123	5	manifested	manifest	VERB
dti-1373	123	6	towards	towards	ADP
dti-1373	123	7	cancer	cancer	NOUN
dti-1373	123	8	therapies	therapy	NOUN
dti-1373	123	9	that	that	PRON
dti-1373	123	10	jointly	jointly	ADV
dti-1373	123	11	target	target	VERB
dti-1373	123	12	ec	ec	PROPN
dti-1373	123	13	angiogenic	angiogenic	ADJ
dti-1373	123	14	and	and	CCONJ
dti-1373	123	15	inflammatory	inflammatory	ADJ
dti-1373	123	16	phenotypes	phenotype	NOUN
dti-1373	123	17	,	,	PUNCT
dti-1373	123	18	the	the	DET
dti-1373	123	19	design	design	NOUN
dti-1373	123	20	,	,	PUNCT
dti-1373	123	21	synthesis	synthesis	NOUN
dti-1373	123	22	and	and	CCONJ
dti-1373	123	23	evaluation	evaluation	NOUN
dti-1373	123	24	of	of	ADP
dti-1373	123	25	flavonoid	flavonoid	NOUN
dti-1373	123	26	derivatives	derivative	NOUN
dti-1373	123	27	that	that	PRON
dti-1373	123	28	target	target	VERB
dti-1373	123	29	neurodegenerative	neurodegenerative	ADJ
dti-1373	123	30	disorders	disorder	NOUN
dti-1373	123	31	have	have	AUX
dti-1373	123	32	accordingly	accordingly	ADV
dti-1373	123	33	paved	pave	VERB
dti-1373	123	34	the	the	DET
dti-1373	123	35	road	road	NOUN
dti-1373	123	36	to	to	ADP
dti-1373	123	37	strategies	strategy	NOUN
dti-1373	123	38	leading	lead	VERB
dti-1373	123	39	to	to	ADP
dti-1373	123	40	decreased	decrease	VERB
dti-1373	123	41	extracellular	extracellular	ADJ
dti-1373	123	42	matrix	matrix	NOUN
dti-1373	123	43	(	(	PUNCT
dti-1373	123	44	ecm	ecm	NOUN
dti-1373	123	45	)	)	PUNCT
dti-1373	123	46	degradation	degradation	NOUN
dti-1373	123	47	and	and	CCONJ
dti-1373	123	48	inflammation	inflammation	NOUN
dti-1373	123	49	processes.30	processes.30	VERB
dti-1373	123	50	the	the	DET
dti-1373	123	51	objectives	objective	NOUN
dti-1373	123	52	of	of	ADP
dti-1373	123	53	this	this	DET
dti-1373	123	54	current	current	ADJ
dti-1373	123	55	study	study	NOUN
dti-1373	123	56	were	be	AUX
dti-1373	123	57	first	first	ADJ
dti-1373	123	58	to	to	PART
dti-1373	123	59	trigger	trigger	VERB
dti-1373	123	60	in	in	ADP
dti-1373	123	61	vitro	vitro	X
dti-1373	123	62	pro	pro	ADJ
dti-1373	123	63	-	-	ADJ
dti-1373	123	64	carcinogenic	carcinogenic	ADJ
dti-1373	123	65	stimulation	stimulation	NOUN
dti-1373	123	66	of	of	ADP
dti-1373	123	67	a	a	DET
dti-1373	123	68	brain	brain	NOUN
dti-1373	123	69	microvascular	microvascular	NOUN
dti-1373	123	70	ec	ec	PROPN
dti-1373	123	71	model	model	NOUN
dti-1373	123	72	using	use	VERB
dti-1373	123	73	pma	pma	NOUN
dti-1373	123	74	in	in	ADP
dti-1373	123	75	combination	combination	NOUN
dti-1373	123	76	with	with	ADP
dti-1373	123	77	resveratrol	resveratrol	NOUN
dti-1373	123	78	,	,	PUNCT
dti-1373	123	79	and	and	CCONJ
dti-1373	123	80	assess	assess	NOUN
dti-1373	123	81	impact	impact	NOUN
dti-1373	123	82	on	on	ADP
dti-1373	123	83	inflammation	inflammation	ADJ
dti-1373	123	84	biomarkers	biomarker	NOUN
dti-1373	123	85	mmp-9	mmp-9	VERB
dti-1373	123	86	and	and	CCONJ
dti-1373	123	87	cox-2	cox-2	DET
dti-1373	123	88	expression	expression	NOUN
dti-1373	123	89	.	.	PUNCT
dti-1373	124	1	secondly	secondly	ADV
dti-1373	124	2	,	,	PUNCT
dti-1373	124	3	given	give	VERB
dti-1373	124	4	that	that	SCONJ
dti-1373	124	5	resveratrol	resveratrol	NOUN
dti-1373	124	6	is	be	AUX
dti-1373	124	7	a	a	DET
dti-1373	124	8	well	well	ADV
dti-1373	124	9	documented	document	VERB
dti-1373	124	10	pharmacological	pharmacological	ADJ
dti-1373	124	11	agonist	agonist	NOUN
dti-1373	124	12	of	of	ADP
dti-1373	124	13	sirt1	sirt1	PROPN
dti-1373	124	14	,	,	PUNCT
dti-1373	124	15	pma	pma	PROPN
dti-1373	124	16	mmp-9	mmp-9	NOUN
dti-1373	124	17	mmp-9	mmp-9	NUM
dti-1373	124	18	0	0	NUM
dti-1373	124	19	10	10	NUM
dti-1373	124	20	20	20	NUM
dti-1373	124	21	2510500	2510500	NUM
dti-1373	125	1	a	a	DET
dti-1373	125	2	c	c	NOUN
dti-1373	125	3	d	d	NOUN
dti-1373	125	4	b	b	PROPN
dti-1373	125	5	0.1	0.1	NUM
dti-1373	125	6	0.3	0.3	NUM
dti-1373	125	7	1	1	NUM
dti-1373	125	8	50	50	NUM
dti-1373	125	9	30	30	NUM
dti-1373	125	10	40	40	NUM
dti-1373	125	11	50	50	NUM
dti-1373	125	12	120	120	NUM
dti-1373	125	13	100	100	NUM
dti-1373	125	14	80	80	NUM
dti-1373	125	15	60	60	NUM
dti-1373	125	16	40	40	NUM
dti-1373	125	17	20	20	NUM
dti-1373	125	18	0	0	NUM
dti-1373	125	19	30	30	NUM
dti-1373	125	20	*	*	SYM
dti-1373	125	21	25	25	NUM
dti-1373	125	22	20	20	NUM
dti-1373	125	23	15	15	NUM
dti-1373	125	24	10	10	NUM
dti-1373	125	25	5	5	NUM
dti-1373	125	26	0	0	NUM
dti-1373	125	27	m	m	VERB
dti-1373	125	28	m	m	VERB
dti-1373	125	29	p	p	ADJ
dti-1373	125	30	-9	-9	INTJ
dti-1373	125	31	(	(	PUNCT
dti-1373	125	32	%	%	INTJ
dti-1373	125	33	o	o	X
dti-1373	125	34	f	f	X
dti-1373	126	1	p	p	X
dti-1373	126	2	m	m	PROPN
dti-1373	126	3	a	a	PRON
dti-1373	126	4	)	)	PUNCT
dti-1373	126	5	m	m	VERB
dti-1373	126	6	m	m	VERB
dti-1373	126	7	p	p	X
dti-1373	126	8	-9	-9	INTJ
dti-1373	126	9	g	g	PROPN
dti-1373	126	10	en	en	X
dti-1373	126	11	e	e	X
dti-1373	126	12	ex	ex	X
dti-1373	126	13	p	p	PROPN
dti-1373	126	14	re	re	ADP
dti-1373	126	15	ss	ss	PROPN
dti-1373	126	16	io	io	X
dti-1373	126	17	n	n	PROPN
dti-1373	126	18	(	(	PUNCT
dti-1373	126	19	x	x	X
dti-1373	126	20	-f	-f	NUM
dti-1373	127	1	o	o	INTJ
dti-1373	127	2	ld	ld	X
dti-1373	127	3	o	o	X
dti-1373	127	4	ve	ve	VERB
dti-1373	127	5	r	r	NOUN
dti-1373	127	6	c	c	NOUN
dti-1373	127	7	tr	tr	NOUN
dti-1373	127	8	l	l	NOUN
dti-1373	127	9	)	)	PUNCT
dti-1373	127	10	pma	pma	NOUN
dti-1373	127	11	(	(	PUNCT
dti-1373	127	12	µm	µm	NOUN
dti-1373	127	13	)	)	PUNCT
dti-1373	127	14	vehicle	vehicle	NOUN
dti-1373	127	15	resveratrol	resveratrol	NOUN
dti-1373	127	16	(	(	PUNCT
dti-1373	127	17	µm	µm	NOUN
dti-1373	127	18	)	)	PUNCT
dti-1373	127	19	resveratrol	resveratrol	NOUN
dti-1373	127	20	(	(	PUNCT
dti-1373	127	21	µm	µm	NOUN
dti-1373	127	22	)	)	PUNCT
dti-1373	127	23	resveratrol−	resveratrol−	NOUN
dti-1373	127	24	+	+	CCONJ
dti-1373	127	25	−	−	X
dti-1373	128	1	+	+	CCONJ
dti-1373	128	2	figure	figure	NOUN
dti-1373	128	3	3	3	NUM
dti-1373	128	4	.	.	PUNCT
dti-1373	129	1	resveratrol	resveratrol	NOUN
dti-1373	129	2	inhibition	inhibition	NOUN
dti-1373	129	3	of	of	ADP
dti-1373	129	4	carcinogen	carcinogen	NOUN
dti-1373	129	5	-	-	PUNCT
dti-1373	129	6	induced	induce	VERB
dti-1373	129	7	mmp-9	mmp-9	NOUN
dti-1373	129	8	gene	gene	NOUN
dti-1373	129	9	expression	expression	NOUN
dti-1373	129	10	and	and	CCONJ
dti-1373	129	11	protein	protein	NOUN
dti-1373	129	12	secretion	secretion	NOUN
dti-1373	129	13	.	.	PUNCT
dti-1373	130	1	hbmec	hbmec	PROPN
dti-1373	130	2	were	be	AUX
dti-1373	130	3	serum	serum	NOUN
dti-1373	130	4	-	-	PUNCT
dti-1373	130	5	starved	starve	VERB
dti-1373	130	6	in	in	ADP
dti-1373	130	7	the	the	DET
dti-1373	130	8	presence	presence	NOUN
dti-1373	130	9	of	of	ADP
dti-1373	130	10	(	(	PUNCT
dti-1373	130	11	a	a	X
dti-1373	130	12	)	)	PUNCT
dti-1373	130	13	various	various	ADJ
dti-1373	130	14	pma	pma	NOUN
dti-1373	130	15	concentrations	concentration	NOUN
dti-1373	130	16	for	for	ADP
dti-1373	130	17	18	18	NUM
dti-1373	130	18	hours	hour	NOUN
dti-1373	130	19	,	,	PUNCT
dti-1373	130	20	or	or	CCONJ
dti-1373	130	21	(	(	PUNCT
dti-1373	130	22	b	b	X
dti-1373	130	23	)	)	PUNCT
dti-1373	130	24	a	a	DET
dti-1373	130	25	combination	combination	NOUN
dti-1373	130	26	of	of	ADP
dti-1373	130	27	1	1	NUM
dti-1373	130	28	µm	µm	ADP
dti-1373	130	29	pma	pma	NOUN
dti-1373	130	30	with	with	ADP
dti-1373	130	31	increasing	increase	VERB
dti-1373	130	32	resveratrol	resveratrol	NOUN
dti-1373	130	33	concentrations	concentration	NOUN
dti-1373	130	34	.	.	PUNCT
dti-1373	131	1	conditioned	condition	VERB
dti-1373	131	2	media	medium	NOUN
dti-1373	131	3	were	be	AUX
dti-1373	131	4	then	then	ADV
dti-1373	131	5	harvested	harvest	VERB
dti-1373	131	6	and	and	CCONJ
dti-1373	131	7	gelatin	gelatin	NOUN
dti-1373	131	8	zymography	zymography	PROPN
dti-1373	131	9	was	be	AUX
dti-1373	131	10	performed	perform	VERB
dti-1373	131	11	in	in	ADP
dti-1373	131	12	order	order	NOUN
dti-1373	131	13	to	to	PART
dti-1373	131	14	detect	detect	VERB
dti-1373	131	15	pma	pma	NOUN
dti-1373	131	16	-	-	PUNCT
dti-1373	131	17	induced	induce	VERB
dti-1373	131	18	prommp-9	prommp-9	NOUN
dti-1373	131	19	and	and	CCONJ
dti-1373	131	20	hydrolytic	hydrolytic	ADJ
dti-1373	131	21	activity	activity	NOUN
dti-1373	131	22	as	as	SCONJ
dti-1373	131	23	described	describe	VERB
dti-1373	131	24	in	in	ADP
dti-1373	131	25	the	the	DET
dti-1373	131	26	methods	method	NOUN
dti-1373	131	27	section	section	NOUN
dti-1373	131	28	.	.	PUNCT
dti-1373	132	1	(	(	PUNCT
dti-1373	132	2	c	c	X
dti-1373	132	3	)	)	PUNCT
dti-1373	132	4	scanning	scan	VERB
dti-1373	132	5	densitometry	densitometry	NOUN
dti-1373	132	6	was	be	AUX
dti-1373	132	7	used	use	VERB
dti-1373	132	8	to	to	PART
dti-1373	132	9	quantify	quantify	VERB
dti-1373	132	10	the	the	DET
dti-1373	132	11	extent	extent	NOUN
dti-1373	132	12	of	of	ADP
dti-1373	132	13	prommp-9	prommp-9	NOUN
dti-1373	132	14	gelatinolytic	gelatinolytic	ADJ
dti-1373	132	15	activity	activity	NOUN
dti-1373	132	16	in	in	ADP
dti-1373	132	17	the	the	DET
dti-1373	132	18	combined	combine	VERB
dti-1373	132	19	pma	pma	NOUN
dti-1373	132	20	and	and	CCONJ
dti-1373	132	21	resveratrol	resveratrol	NOUN
dti-1373	132	22	treatments	treatment	NOUN
dti-1373	132	23	.	.	PUNCT
dti-1373	133	1	data	datum	NOUN
dti-1373	133	2	shown	show	VERB
dti-1373	133	3	is	be	AUX
dti-1373	133	4	representative	representative	NOUN
dti-1373	133	5	of	of	ADP
dti-1373	133	6	two	two	NUM
dti-1373	133	7	independent	independent	ADJ
dti-1373	133	8	experiments	experiment	NOUN
dti-1373	133	9	.	.	PUNCT
dti-1373	134	1	(	(	PUNCT
dti-1373	134	2	d	d	X
dti-1373	134	3	)	)	PUNCT
dti-1373	134	4	total	total	ADJ
dti-1373	134	5	rna	rna	NOUN
dti-1373	134	6	isolation	isolation	NOUN
dti-1373	134	7	and	and	CCONJ
dti-1373	134	8	qrt	qrt	NOUN
dti-1373	134	9	-	-	PUNCT
dti-1373	134	10	pcr	pcr	NOUN
dti-1373	134	11	were	be	AUX
dti-1373	134	12	performed	perform	VERB
dti-1373	134	13	as	as	SCONJ
dti-1373	134	14	described	describe	VERB
dti-1373	134	15	in	in	ADP
dti-1373	134	16	the	the	DET
dti-1373	134	17	methods	method	NOUN
dti-1373	134	18	section	section	NOUN
dti-1373	134	19	to	to	PART
dti-1373	134	20	assess	assess	VERB
dti-1373	134	21	mmp-9	mmp-9	VERB
dti-1373	134	22	gene	gene	NOUN
dti-1373	134	23	expression	expression	NOUN
dti-1373	134	24	in	in	ADP
dti-1373	134	25	the	the	DET
dti-1373	134	26	above	above	ADV
dti-1373	134	27	-	-	PUNCT
dti-1373	134	28	described	describe	VERB
dti-1373	134	29	conditions	condition	NOUN
dti-1373	134	30	.	.	PUNCT
dti-1373	135	1	(	(	PUNCT
dti-1373	135	2	pma	pma	NOUN
dti-1373	135	3	=	=	NOUN
dti-1373	135	4	1	1	NUM
dti-1373	135	5	µm	µm	NUM
dti-1373	135	6	;	;	PUNCT
dti-1373	135	7	resveratrol	resveratrol	NOUN
dti-1373	135	8	=	=	SYM
dti-1373	135	9	30	30	NUM
dti-1373	135	10	µm	µm	NOUN
dti-1373	135	11	)	)	PUNCT
dti-1373	135	12	.	.	PUNCT
dti-1373	136	1	notes	note	NOUN
dti-1373	136	2	:	:	PUNCT
dti-1373	136	3	data	datum	NOUN
dti-1373	136	4	are	be	AUX
dti-1373	136	5	representative	representative	NOUN
dti-1373	136	6	of	of	ADP
dti-1373	136	7	three	three	NUM
dti-1373	136	8	independent	independent	ADJ
dti-1373	136	9	qpcr	qpcr	ADJ
dti-1373	136	10	experiments	experiment	NOUN
dti-1373	136	11	.	.	PUNCT
dti-1373	137	1	probability	probability	NOUN
dti-1373	137	2	values	value	NOUN
dti-1373	137	3	of	of	ADP
dti-1373	137	4	less	less	ADJ
dti-1373	137	5	than	than	ADP
dti-1373	137	6	0.05	0.05	NUM
dti-1373	137	7	were	be	AUX
dti-1373	137	8	considered	consider	VERB
dti-1373	137	9	significant	significant	ADJ
dti-1373	137	10	,	,	PUNCT
dti-1373	137	11	and	and	CCONJ
dti-1373	137	12	an	an	DET
dti-1373	137	13	asterisk	asterisk	NOUN
dti-1373	137	14	(	(	PUNCT
dti-1373	137	15	*	*	PUNCT
dti-1373	137	16	)	)	PUNCT
dti-1373	137	17	identifies	identify	VERB
dti-1373	137	18	such	such	ADJ
dti-1373	137	19	significance	significance	NOUN
dti-1373	137	20	to	to	ADP
dti-1373	137	21	the	the	DET
dti-1373	137	22	respective	respective	ADJ
dti-1373	137	23	pma	pma	NOUN
dti-1373	137	24	treatment	treatment	NOUN
dti-1373	137	25	.	.	PUNCT
dti-1373	137	26	http://www.la-press.com	http://www.la-press.com	X
dti-1373	138	1	sirt1	sirt1	NOUN
dti-1373	138	2	expression	expression	NOUN
dti-1373	138	3	in	in	ADP
dti-1373	138	4	inflammatory	inflammatory	ADJ
dti-1373	138	5	cerebral	cerebral	ADJ
dti-1373	138	6	endothelium	endothelium	NOUN
dti-1373	138	7	drug	drug	NOUN
dti-1373	138	8	target	target	NOUN
dti-1373	138	9	insights	insight	NOUN
dti-1373	138	10	2012:6	2012:6	NUM
dti-1373	138	11	7	7	NUM
dti-1373	138	12	but	but	CCONJ
dti-1373	138	13	that	that	DET
dti-1373	138	14	conflicting	conflicting	ADJ
dti-1373	138	15	data	datum	NOUN
dti-1373	138	16	regarding	regard	VERB
dti-1373	138	17	sirt1	sirt1	NOUN
dti-1373	138	18	expression	expression	NOUN
dti-1373	138	19	in	in	ADP
dti-1373	138	20	glioblastoma	glioblastoma	NOUN
dti-1373	138	21	has	have	AUX
dti-1373	138	22	been	be	AUX
dti-1373	138	23	reported,17–19	reported,17–19	VERB
dti-1373	138	24	we	we	PRON
dti-1373	138	25	specifically	specifically	ADV
dti-1373	138	26	explored	explore	VERB
dti-1373	138	27	its	its	PRON
dti-1373	138	28	contribution	contribution	NOUN
dti-1373	138	29	to	to	ADP
dti-1373	138	30	the	the	DET
dti-1373	138	31	resveratrol	resveratrol	NOUN
dti-1373	138	32	anti	anti	ADJ
dti-1373	138	33	-	-	ADJ
dti-1373	138	34	pma	pma	ADJ
dti-1373	138	35	pharmacological	pharmacological	NOUN
dti-1373	138	36	properties	property	NOUN
dti-1373	138	37	.	.	PUNCT
dti-1373	139	1	our	our	PRON
dti-1373	139	2	first	first	ADJ
dti-1373	139	3	objective	objective	NOUN
dti-1373	139	4	was	be	AUX
dti-1373	139	5	confirmed	confirm	VERB
dti-1373	139	6	by	by	ADP
dti-1373	139	7	the	the	DET
dti-1373	139	8	increases	increase	NOUN
dti-1373	139	9	in	in	ADP
dti-1373	139	10	inflammatory	inflammatory	ADJ
dti-1373	139	11	biomarkers	biomarker	NOUN
dti-1373	139	12	mmp-9	mmp-9	NOUN
dti-1373	139	13	and	and	CCONJ
dti-1373	139	14	cox-2	cox-2	ADJ
dti-1373	139	15	expression	expression	NOUN
dti-1373	139	16	upon	upon	SCONJ
dti-1373	139	17	carcinogenic	carcinogenic	ADJ
dti-1373	139	18	stimulation	stimulation	NOUN
dti-1373	139	19	in	in	ADP
dti-1373	139	20	hbmec	hbmec	NOUN
dti-1373	139	21	.	.	PUNCT
dti-1373	140	1	as	as	ADP
dti-1373	140	2	such	such	ADJ
dti-1373	140	3	,	,	PUNCT
dti-1373	140	4	the	the	DET
dti-1373	140	5	calculated	calculated	ADJ
dti-1373	140	6	ic50	ic50	PROPN
dti-1373	140	7	concentrations	concentration	NOUN
dti-1373	140	8	of	of	ADP
dti-1373	140	9	resveratrol	resveratrol	NOUN
dti-1373	140	10	inhibitory	inhibitory	ADJ
dti-1373	140	11	effects	effect	NOUN
dti-1373	140	12	extracted	extract	VERB
dti-1373	140	13	from	from	ADP
dti-1373	140	14	our	our	PRON
dti-1373	140	15	in	in	X
dti-1373	140	16	vitro	vitro	X
dti-1373	140	17	model	model	NOUN
dti-1373	140	18	closely	closely	ADV
dti-1373	140	19	approximate	approximate	VERB
dti-1373	140	20	those	those	DET
dti-1373	140	21	actual	actual	ADJ
dti-1373	140	22	concentrations	concentration	NOUN
dti-1373	140	23	assessed	assess	VERB
dti-1373	140	24	in	in	ADP
dti-1373	140	25	the	the	DET
dti-1373	140	26	plasma	plasma	NOUN
dti-1373	140	27	ranging	range	VERB
dti-1373	140	28	between	between	ADP
dti-1373	140	29	1.2–2.6	1.2–2.6	NUM
dti-1373	140	30	µm.31,32	µm.31,32	VERB
dti-1373	140	31	both	both	DET
dti-1373	140	32	biomarkers	biomarker	NOUN
dti-1373	140	33	expression	expression	NOUN
dti-1373	140	34	was	be	AUX
dti-1373	140	35	inhibited	inhibit	VERB
dti-1373	140	36	by	by	ADP
dti-1373	140	37	resveratrol	resveratrol	NOUN
dti-1373	140	38	and	and	CCONJ
dti-1373	140	39	this	this	DET
dti-1373	140	40	required	require	VERB
dti-1373	140	41	inhibition	inhibition	NOUN
dti-1373	140	42	of	of	ADP
dti-1373	140	43	the	the	DET
dti-1373	140	44	nf	nf	NOUN
dti-1373	140	45	-	-	PUNCT
dti-1373	140	46	κb	κb	NOUN
dti-1373	140	47	signaling	signal	VERB
dti-1373	140	48	pathway	pathway	NOUN
dti-1373	140	49	as	as	SCONJ
dti-1373	140	50	validated	validate	VERB
dti-1373	140	51	by	by	ADP
dti-1373	140	52	reduced	reduce	VERB
dti-1373	140	53	iκb	iκb	NOUN
dti-1373	140	54	phosphorylation	phosphorylation	NOUN
dti-1373	140	55	.	.	PUNCT
dti-1373	141	1	inhibition	inhibition	NOUN
dti-1373	141	2	of	of	ADP
dti-1373	141	3	nf	nf	NOUN
dti-1373	141	4	-	-	PUNCT
dti-1373	141	5	κb	κb	NOUN
dti-1373	141	6	(	(	PUNCT
dti-1373	141	7	p65	p65	NOUN
dti-1373	141	8	subunit	subunit	NOUN
dti-1373	141	9	)	)	PUNCT
dti-1373	141	10	translocation	translocation	NOUN
dti-1373	141	11	to	to	ADP
dti-1373	141	12	the	the	DET
dti-1373	141	13	nucleus	nucleus	NOUN
dti-1373	141	14	by	by	ADP
dti-1373	141	15	resveratrol	resveratrol	NOUN
dti-1373	141	16	is	be	AUX
dti-1373	141	17	a	a	DET
dti-1373	141	18	mechanism	mechanism	NOUN
dti-1373	141	19	that	that	PRON
dti-1373	141	20	has	have	AUX
dti-1373	141	21	already	already	ADV
dti-1373	141	22	been	be	AUX
dti-1373	141	23	inferred	infer	VERB
dti-1373	141	24	in	in	ADP
dti-1373	141	25	an	an	DET
dti-1373	141	26	experimental	experimental	ADJ
dti-1373	141	27	hepatocarcinogenesis	hepatocarcinogenesis	NOUN
dti-1373	141	28	model.33	model.33	VERB
dti-1373	141	29	our	our	PRON
dti-1373	141	30	data	datum	NOUN
dti-1373	141	31	thus	thus	ADV
dti-1373	141	32	indirectly	indirectly	ADV
dti-1373	141	33	support	support	VERB
dti-1373	141	34	this	this	DET
dti-1373	141	35	nuclear	nuclear	ADJ
dti-1373	141	36	translocation	translocation	NOUN
dti-1373	141	37	effect	effect	NOUN
dti-1373	141	38	since	since	SCONJ
dti-1373	141	39	iκb	iκb	NOUN
dti-1373	141	40	phosphorylation	phosphorylation	NOUN
dti-1373	141	41	,	,	PUNCT
dti-1373	141	42	which	which	PRON
dti-1373	141	43	ultimately	ultimately	ADV
dti-1373	141	44	releases	release	VERB
dti-1373	141	45	p65	p65	NOUN
dti-1373	141	46	and	and	CCONJ
dti-1373	141	47	p50	p50	NOUN
dti-1373	141	48	in	in	ADP
dti-1373	141	49	order	order	NOUN
dti-1373	141	50	to	to	PART
dti-1373	141	51	allow	allow	VERB
dti-1373	141	52	nuclear	nuclear	ADJ
dti-1373	141	53	translocation	translocation	NOUN
dti-1373	141	54	,	,	PUNCT
dti-1373	141	55	was	be	AUX
dti-1373	141	56	found	find	VERB
dti-1373	141	57	inhibited	inhibit	VERB
dti-1373	141	58	by	by	ADP
dti-1373	141	59	resveratrol	resveratrol	NOUN
dti-1373	141	60	in	in	ADP
dti-1373	141	61	our	our	PRON
dti-1373	141	62	model	model	NOUN
dti-1373	141	63	(	(	PUNCT
dti-1373	141	64	fig	fig	NOUN
dti-1373	141	65	.	.	PUNCT
dti-1373	142	1	4b	4b	PROPN
dti-1373	142	2	)	)	PUNCT
dti-1373	142	3	.	.	PUNCT
dti-1373	143	1	although	although	SCONJ
dti-1373	143	2	not	not	PART
dti-1373	143	3	the	the	DET
dti-1373	143	4	scope	scope	NOUN
dti-1373	143	5	of	of	ADP
dti-1373	143	6	this	this	DET
dti-1373	143	7	study	study	NOUN
dti-1373	143	8	,	,	PUNCT
dti-1373	143	9	chip	chip	NOUN
dti-1373	143	10	assays	assay	NOUN
dti-1373	143	11	may	may	AUX
dti-1373	143	12	further	far	ADV
dti-1373	143	13	help	help	VERB
dti-1373	143	14	address	address	VERB
dti-1373	143	15	nf	nf	ADJ
dti-1373	143	16	-	-	PUNCT
dti-1373	143	17	κb	κb	NOUN
dti-1373	143	18	capacity	capacity	NOUN
dti-1373	143	19	to	to	PART
dti-1373	143	20	bind	bind	VERB
dti-1373	143	21	cox-2	cox-2	ADP
dti-1373	143	22	and	and	CCONJ
dti-1373	143	23	mmp-9	mmp-9	NOUN
dti-1373	143	24	promoter	promoter	NOUN
dti-1373	143	25	regions	region	NOUN
dti-1373	143	26	.	.	PUNCT
dti-1373	144	1	given	give	VERB
dti-1373	144	2	that	that	SCONJ
dti-1373	144	3	the	the	DET
dti-1373	144	4	involvement	involvement	NOUN
dti-1373	144	5	of	of	ADP
dti-1373	144	6	sirt1still	sirt1still	NOUN
dti-1373	144	7	remains	remain	VERB
dti-1373	144	8	undefined	undefined	ADJ
dti-1373	144	9	,	,	PUNCT
dti-1373	144	10	at	at	ADP
dti-1373	144	11	least	least	ADJ
dti-1373	144	12	within	within	ADP
dti-1373	144	13	the	the	DET
dti-1373	144	14	carcinogenic	carcinogenic	ADJ
dti-1373	144	15	context	context	NOUN
dti-1373	144	16	we	we	PRON
dti-1373	144	17	report	report	VERB
dti-1373	144	18	herein	herein	NOUN
dti-1373	144	19	,	,	PUNCT
dti-1373	144	20	our	our	PRON
dti-1373	144	21	second	second	ADJ
dti-1373	144	22	objective	objective	NOUN
dti-1373	144	23	was	be	AUX
dti-1373	144	24	evaluated	evaluate	VERB
dti-1373	144	25	and	and	CCONJ
dti-1373	144	26	confirmed	confirm	VERB
dti-1373	144	27	a	a	DET
dti-1373	144	28	sirt1	sirt1	NOUN
dti-1373	144	29	-	-	ADJ
dti-1373	144	30	independent	independent	ADJ
dti-1373	144	31	,	,	PUNCT
dti-1373	144	32	but	but	CCONJ
dti-1373	144	33	efficient	efficient	ADJ
dti-1373	144	34	,	,	PUNCT
dti-1373	144	35	targeting	target	VERB
dti-1373	144	36	by	by	ADP
dti-1373	144	37	resveratrol	resveratrol	NOUN
dti-1373	144	38	of	of	ADP
dti-1373	144	39	the	the	DET
dti-1373	144	40	pma	pma	NOUN
dti-1373	144	41	-	-	PUNCT
dti-1373	144	42	induced	induce	VERB
dti-1373	144	43	nf	nf	ADJ
dti-1373	144	44	-	-	PUNCT
dti-1373	144	45	κb	κb	NOUN
dti-1373	144	46	signaling	signal	VERB
dti-1373	144	47	pathway	pathway	NOUN
dti-1373	144	48	that	that	PRON
dti-1373	144	49	ultimately	ultimately	ADV
dti-1373	144	50	leads	lead	VERB
dti-1373	144	51	to	to	AUX
dti-1373	144	52	reduced	reduce	VERB
dti-1373	144	53	120	120	NUM
dti-1373	144	54	100	100	NUM
dti-1373	144	55	80	80	NUM
dti-1373	144	56	∗	∗	NOUN
dti-1373	144	57	∗	∗	NOUN
dti-1373	144	58	∗	∗	NOUN
dti-1373	144	59	60	60	NUM
dti-1373	144	60	40	40	NUM
dti-1373	144	61	20	20	NUM
dti-1373	144	62	0	0	NUM
dti-1373	144	63	0	0	NUM
dti-1373	144	64	5	5	NUM
dti-1373	144	65	10	10	NUM
dti-1373	144	66	15	15	NUM
dti-1373	144	67	resveratrol	resveratrol	NOUN
dti-1373	144	68	r	r	NOUN
dti-1373	144	69	es	es	NOUN
dti-1373	144	70	ve	ve	VERB
dti-1373	144	71	ra	ra	NOUN
dti-1373	144	72	tr	tr	VERB
dti-1373	144	73	ol	ol	ADJ
dti-1373	144	74	vehicle	vehicle	NOUN
dti-1373	144	75	v	v	INTJ
dti-1373	144	76	eh	eh	INTJ
dti-1373	144	77	ic	ic	PROPN
dti-1373	144	78	le	le	PROPN
dti-1373	144	79	time	time	PROPN
dti-1373	144	80	(	(	PUNCT
dti-1373	144	81	min	min	NOUN
dti-1373	144	82	)	)	PUNCT
dti-1373	144	83	p	p	NOUN
dti-1373	144	84	lκ	lκ	PROPN
dti-1373	144	85	b	b	PROPN
dti-1373	144	86	/g	/g	PUNCT
dti-1373	144	87	a	a	DET
dti-1373	144	88	p	p	X
dti-1373	144	89	d	d	X
dti-1373	144	90	h	h	NOUN
dti-1373	144	91	(	(	PUNCT
dti-1373	144	92	a	a	DET
dti-1373	144	93	rb	rb	NOUN
dti-1373	144	94	.	.	PUNCT
dti-1373	145	1	u	u	PRON
dti-1373	145	2	n	n	CCONJ
dti-1373	145	3	it	it	PRON
dti-1373	145	4	s	s	VERB
dti-1373	145	5	)	)	PUNCT
dti-1373	145	6	20	20	NUM
dti-1373	145	7	25	25	NUM
dti-1373	145	8	30	30	NUM
dti-1373	145	9	0	0	NUM
dti-1373	146	1	a	a	DET
dti-1373	146	2	b	b	NOUN
dti-1373	146	3	2	2	NUM
dti-1373	146	4	5	5	NUM
dti-1373	146	5	10	10	NUM
dti-1373	146	6	time	time	NOUN
dti-1373	146	7	of	of	ADP
dti-1373	146	8	pma	pma	NOUN
dti-1373	146	9	treatment	treatment	NOUN
dti-1373	146	10	(	(	PUNCT
dti-1373	146	11	min	min	NOUN
dti-1373	146	12	)	)	PUNCT
dti-1373	146	13	15	15	NUM
dti-1373	146	14	20	20	NUM
dti-1373	146	15	25	25	NUM
dti-1373	146	16	30	30	NUM
dti-1373	146	17	plκb	plκb	NOUN
dti-1373	146	18	gapdh	gapdh	NOUN
dti-1373	146	19	plκb	plκb	NOUN
dti-1373	146	20	gapdh	gapdh	NOUN
dti-1373	146	21	figure	figure	NOUN
dti-1373	146	22	4	4	NUM
dti-1373	146	23	.	.	PUNCT
dti-1373	146	24	carcinogen	carcinogen	NOUN
dti-1373	146	25	-	-	PUNCT
dti-1373	146	26	induced	induce	VERB
dti-1373	146	27	iκb	iκb	NOUN
dti-1373	146	28	phosphorylation	phosphorylation	NOUN
dti-1373	146	29	is	be	AUX
dti-1373	146	30	inhibited	inhibit	VERB
dti-1373	146	31	by	by	ADP
dti-1373	146	32	resveratrol	resveratrol	NOUN
dti-1373	146	33	.	.	PUNCT
dti-1373	147	1	(	(	PUNCT
dti-1373	147	2	a	a	X
dti-1373	147	3	)	)	PUNCT
dti-1373	147	4	hbmec	hbmec	NOUN
dti-1373	147	5	were	be	AUX
dti-1373	147	6	serum	serum	NOUN
dti-1373	147	7	-	-	PUNCT
dti-1373	147	8	starved	starve	VERB
dti-1373	147	9	for	for	ADP
dti-1373	147	10	30	30	NUM
dti-1373	147	11	minutes	minute	NOUN
dti-1373	147	12	in	in	ADP
dti-1373	147	13	the	the	DET
dti-1373	147	14	presence	presence	NOUN
dti-1373	147	15	or	or	CCONJ
dti-1373	147	16	not	not	PART
dti-1373	147	17	of	of	ADP
dti-1373	147	18	30	30	NUM
dti-1373	147	19	µm	µm	NOUN
dti-1373	147	20	resveratrol	resveratrol	NOUN
dti-1373	147	21	,	,	PUNCT
dti-1373	147	22	then	then	ADV
dti-1373	147	23	treated	treat	VERB
dti-1373	147	24	with	with	ADP
dti-1373	147	25	1	1	NUM
dti-1373	147	26	µm	µm	ADP
dti-1373	147	27	pma	pma	NOUN
dti-1373	147	28	for	for	ADP
dti-1373	147	29	the	the	DET
dti-1373	147	30	indicated	indicate	VERB
dti-1373	147	31	time	time	NOUN
dti-1373	147	32	.	.	PUNCT
dti-1373	148	1	lysates	lysate	NOUN
dti-1373	148	2	were	be	AUX
dti-1373	148	3	isolated	isolate	VERB
dti-1373	148	4	,	,	PUNCT
dti-1373	148	5	electrophoresed	electrophorese	VERB
dti-1373	148	6	via	via	ADP
dti-1373	148	7	sds	sds	NOUN
dti-1373	148	8	-	-	PUNCT
dti-1373	148	9	page	page	NOUN
dti-1373	148	10	and	and	CCONJ
dti-1373	148	11	immunodetection	immunodetection	NOUN
dti-1373	148	12	of	of	ADP
dti-1373	148	13	phosphorylated	phosphorylate	VERB
dti-1373	148	14	iκb	iκb	NOUN
dti-1373	148	15	(	(	PUNCT
dti-1373	148	16	p	p	NOUN
dti-1373	148	17	-	-	PUNCT
dti-1373	148	18	iκb	iκb	NOUN
dti-1373	148	19	)	)	PUNCT
dti-1373	148	20	and	and	CCONJ
dti-1373	148	21	gapdh	gapdh	NOUN
dti-1373	148	22	proteins	protein	NOUN
dti-1373	148	23	was	be	AUX
dti-1373	148	24	performed	perform	VERB
dti-1373	148	25	as	as	SCONJ
dti-1373	148	26	described	describe	VERB
dti-1373	148	27	in	in	ADP
dti-1373	148	28	the	the	DET
dti-1373	148	29	methods	method	NOUN
dti-1373	148	30	section	section	NOUN
dti-1373	148	31	.	.	PUNCT
dti-1373	149	1	(	(	PUNCT
dti-1373	149	2	b	b	X
dti-1373	149	3	)	)	PUNCT
dti-1373	149	4	quantification	quantification	NOUN
dti-1373	149	5	was	be	AUX
dti-1373	149	6	performed	perform	VERB
dti-1373	149	7	by	by	ADP
dti-1373	149	8	scanning	scan	VERB
dti-1373	149	9	densitometry	densitometry	NOUN
dti-1373	149	10	of	of	ADP
dti-1373	149	11	the	the	DET
dti-1373	149	12	autoradiograms	autoradiogram	NOUN
dti-1373	149	13	.	.	PUNCT
dti-1373	150	1	notes	note	NOUN
dti-1373	150	2	:	:	PUNCT
dti-1373	150	3	data	datum	NOUN
dti-1373	150	4	were	be	AUX
dti-1373	150	5	expressed	express	VERB
dti-1373	150	6	as	as	ADP
dti-1373	150	7	the	the	DET
dti-1373	150	8	percent	percent	NOUN
dti-1373	150	9	of	of	ADP
dti-1373	150	10	basal	basal	ADJ
dti-1373	150	11	phospho	phospho	ADJ
dti-1373	150	12	-	-	PUNCT
dti-1373	150	13	iκb	iκb	NOUN
dti-1373	150	14	/	/	SYM
dti-1373	150	15	gapdh	gapdh	NOUN
dti-1373	150	16	ratios	ratio	NOUN
dti-1373	150	17	in	in	ADP
dti-1373	150	18	vehicle	vehicle	NOUN
dti-1373	150	19	(	(	PUNCT
dti-1373	150	20	open	open	ADJ
dti-1373	150	21	circles	circle	NOUN
dti-1373	150	22	)	)	PUNCT
dti-1373	150	23	and	and	CCONJ
dti-1373	150	24	resveratrol	resveratrol	NOUN
dti-1373	150	25	pre	pre	ADJ
dti-1373	150	26	-	-	ADJ
dti-1373	150	27	treated	treat	VERB
dti-1373	150	28	cells	cell	NOUN
dti-1373	150	29	(	(	PUNCT
dti-1373	150	30	closed	closed	ADJ
dti-1373	150	31	circles	circle	NOUN
dti-1373	150	32	)	)	PUNCT
dti-1373	150	33	.	.	PUNCT
dti-1373	151	1	densitometric	densitometric	ADJ
dti-1373	151	2	data	datum	NOUN
dti-1373	151	3	of	of	ADP
dti-1373	151	4	a	a	DET
dti-1373	151	5	representative	representative	ADJ
dti-1373	151	6	blot	blot	NOUN
dti-1373	151	7	out	out	ADP
dti-1373	151	8	of	of	ADP
dti-1373	151	9	three	three	NUM
dti-1373	151	10	is	be	AUX
dti-1373	151	11	shown	show	VERB
dti-1373	151	12	.	.	PUNCT
dti-1373	152	1	http://www.la-press.com	http://www.la-press.com	X
dti-1373	152	2	annabi	annabi	PROPN
dti-1373	152	3	et	et	PROPN
dti-1373	152	4	al	al	PROPN
dti-1373	152	5	8	8	NUM
dti-1373	152	6	drug	drug	NOUN
dti-1373	152	7	target	target	NOUN
dti-1373	152	8	insights	insight	NOUN
dti-1373	152	9	2012:6	2012:6	NUM
dti-1373	152	10	mmp-9	mmp-9	NOUN
dti-1373	152	11	and	and	CCONJ
dti-1373	152	12	cox-2	cox-2	DET
dti-1373	152	13	expression	expression	NOUN
dti-1373	152	14	.	.	PUNCT
dti-1373	153	1	our	our	PRON
dti-1373	153	2	current	current	ADJ
dti-1373	153	3	data	datum	NOUN
dti-1373	153	4	do	do	AUX
dti-1373	153	5	not	not	PART
dti-1373	153	6	support	support	VERB
dti-1373	153	7	sirt1	sirt1	NOUN
dti-1373	153	8	requirements	requirement	NOUN
dti-1373	153	9	in	in	ADP
dti-1373	153	10	our	our	PRON
dti-1373	153	11	brain	brain	NOUN
dti-1373	153	12	ec	ec	PROPN
dti-1373	153	13	model	model	NOUN
dti-1373	153	14	suggesting	suggest	VERB
dti-1373	153	15	that	that	SCONJ
dti-1373	153	16	cell	cell	NOUN
dti-1373	153	17	specificity	specificity	NOUN
dti-1373	153	18	may	may	AUX
dti-1373	153	19	dictate	dictate	VERB
dti-1373	153	20	resveratrol	resveratrol	NOUN
dti-1373	153	21	efficacy	efficacy	NOUN
dti-1373	153	22	in	in	ADP
dti-1373	153	23	inhibiting	inhibit	VERB
dti-1373	153	24	mmp-9	mmp-9	NOUN
dti-1373	153	25	in	in	ADP
dti-1373	153	26	neuroinflammation	neuroinflammation	NOUN
dti-1373	153	27	or	or	CCONJ
dti-1373	153	28	brain	brain	NOUN
dti-1373	153	29	tumor	tumor	NOUN
dti-1373	153	30	angiogenesis	angiogenesis	NOUN
dti-1373	153	31	.	.	PUNCT
dti-1373	154	1	in	in	ADP
dti-1373	154	2	accordance	accordance	NOUN
dti-1373	154	3	with	with	ADP
dti-1373	154	4	our	our	PRON
dti-1373	154	5	current	current	ADJ
dti-1373	154	6	study	study	NOUN
dti-1373	154	7	,	,	PUNCT
dti-1373	154	8	the	the	DET
dti-1373	154	9	presence	presence	NOUN
dti-1373	154	10	or	or	CCONJ
dti-1373	154	11	absence	absence	NOUN
dti-1373	154	12	of	of	ADP
dti-1373	154	13	sirt1	sirt1	NOUN
dti-1373	154	14	,	,	PUNCT
dti-1373	154	15	as	as	SCONJ
dti-1373	154	16	assessed	assess	VERB
dti-1373	154	17	through	through	ADP
dti-1373	154	18	the	the	DET
dti-1373	154	19	use	use	NOUN
dti-1373	154	20	of	of	ADP
dti-1373	154	21	sirt1	sirt1	ADJ
dti-1373	154	22	-	-	ADJ
dti-1373	154	23	null	null	ADJ
dti-1373	154	24	animals	animal	NOUN
dti-1373	154	25	,	,	PUNCT
dti-1373	154	26	had	have	VERB
dti-1373	154	27	no	no	DET
dti-1373	154	28	effect	effect	NOUN
dti-1373	154	29	on	on	ADP
dti-1373	154	30	incidence	incidence	NOUN
dti-1373	154	31	and	and	CCONJ
dti-1373	154	32	tumor	tumor	NOUN
dti-1373	154	33	load	load	NOUN
dti-1373	154	34	induced	induce	VERB
dti-1373	154	35	by	by	ADP
dti-1373	154	36	a	a	DET
dti-1373	154	37	two	two	NUM
dti-1373	154	38	-	-	PUNCT
dti-1373	154	39	stage	stage	NOUN
dti-1373	154	40	carcinogenesis	carcinogenesis	NOUN
dti-1373	154	41	protocol.42	protocol.42	NOUN
dti-1373	154	42	in	in	ADP
dti-1373	154	43	fact	fact	NOUN
dti-1373	154	44	,	,	PUNCT
dti-1373	154	45	only	only	ADV
dti-1373	154	46	part	part	NOUN
dti-1373	154	47	of	of	ADP
dti-1373	154	48	the	the	DET
dti-1373	154	49	chemopreventive	chemopreventive	ADJ
dti-1373	154	50	effect	effect	NOUN
dti-1373	154	51	of	of	ADP
dti-1373	154	52	resveratrol	resveratrol	NOUN
dti-1373	154	53	was	be	AUX
dti-1373	154	54	attributed	attribute	VERB
dti-1373	154	55	to	to	ADP
dti-1373	154	56	sirt1.34	sirt1.34	NOUN
dti-1373	154	57	moreover	moreover	ADV
dti-1373	154	58	,	,	PUNCT
dti-1373	154	59	while	while	SCONJ
dti-1373	154	60	most	most	ADJ
dti-1373	154	61	biological	biological	ADJ
dti-1373	154	62	effects	effect	NOUN
dti-1373	154	63	of	of	ADP
dti-1373	154	64	sirtuins	sirtuin	NOUN
dti-1373	154	65	have	have	AUX
dti-1373	154	66	so	so	ADV
dti-1373	154	67	far	far	ADV
dti-1373	154	68	been	be	AUX
dti-1373	154	69	attributed	attribute	VERB
dti-1373	154	70	to	to	ADP
dti-1373	154	71	their	their	PRON
dti-1373	154	72	enzymatic	enzymatic	ADJ
dti-1373	154	73	activity	activity	NOUN
dti-1373	154	74	,	,	PUNCT
dti-1373	154	75	opposing	oppose	VERB
dti-1373	154	76	effects	effect	NOUN
dti-1373	154	77	of	of	ADP
dti-1373	154	78	sirtuins	sirtuin	NOUN
dti-1373	154	79	on	on	ADP
dti-1373	154	80	neuronal	neuronal	ADJ
dti-1373	154	81	survival	survival	NOUN
dti-1373	154	82	have	have	AUX
dti-1373	154	83	also	also	ADV
dti-1373	154	84	been	be	AUX
dti-1373	154	85	reported	report	VERB
dti-1373	154	86	suggestive	suggestive	ADJ
dti-1373	154	87	of	of	ADP
dti-1373	154	88	sirt1	sirt1	NOUN
dti-1373	154	89	-	-	PUNCT
dti-1373	154	90	mediated	mediate	VERB
dti-1373	154	91	neuroprotection	neuroprotection	NOUN
dti-1373	154	92	independent	independent	NOUN
dti-1373	154	93	of	of	ADP
dti-1373	154	94	deacetylase	deacetylase	NOUN
dti-1373	154	95	activity.35	activity.35	NOUN
dti-1373	154	96	although	although	SCONJ
dti-1373	154	97	resveratrol	resveratrol	NOUN
dti-1373	154	98	is	be	AUX
dti-1373	154	99	a	a	DET
dti-1373	154	100	potent	potent	ADJ
dti-1373	154	101	pharmacological	pharmacological	ADJ
dti-1373	154	102	agonist	agonist	NOUN
dti-1373	154	103	of	of	ADP
dti-1373	154	104	sirt1,36	sirt1,36	NOUN
dti-1373	154	105	and	and	CCONJ
dti-1373	154	106	expected	expect	VERB
dti-1373	154	107	b	b	PROPN
dti-1373	154	108	a	a	DET
dti-1373	154	109	s	s	X
dti-1373	154	110	ir	ir	NOUN
dti-1373	154	111	t1	t1	NOUN
dti-1373	154	112	g	g	PROPN
dti-1373	154	113	en	en	X
dti-1373	154	114	e	e	X
dti-1373	154	115	ex	ex	X
dti-1373	154	116	p	p	PROPN
dti-1373	154	117	re	re	ADP
dti-1373	154	118	ss	ss	PROPN
dti-1373	154	119	io	io	X
dti-1373	154	120	n	n	PROPN
dti-1373	154	121	(	(	PUNCT
dti-1373	154	122	%	%	INTJ
dti-1373	155	1	o	o	X
dti-1373	155	2	f	f	NOUN
dti-1373	156	1	m	m	VERB
dti-1373	156	2	o	o	NOUN
dti-1373	156	3	ck	ck	INTJ
dti-1373	156	4	)	)	PUNCT
dti-1373	157	1	r	r	NOUN
dti-1373	157	2	es	es	NOUN
dti-1373	157	3	ve	ve	VERB
dti-1373	157	4	ra	ra	NOUN
dti-1373	157	5	tr	tr	NOUN
dti-1373	157	6	o	o	NOUN
dti-1373	157	7	l	l	NOUN
dti-1373	158	1	i	i	PRON
dti-1373	158	2	n	n	VERB
dti-1373	158	3	h	h	NOUN
dti-1373	158	4	ib	ib	INTJ
dti-1373	158	5	it	it	PRON
dti-1373	159	1	o	o	INTJ
dti-1373	160	1	ry	ry	INTJ
dti-1373	160	2	p	p	X
dti-1373	160	3	o	o	X
dti-1373	160	4	te	te	ADP
dti-1373	160	5	n	n	X
dti-1373	160	6	cy	cy	PROPN
dti-1373	160	7	(	(	PUNCT
dti-1373	160	8	ar	ar	PROPN
dti-1373	160	9	b	b	PROPN
dti-1373	160	10	.	.	PUNCT
dti-1373	161	1	u	u	PROPN
dti-1373	161	2	n	n	CCONJ
dti-1373	161	3	it	it	PRON
dti-1373	161	4	s	s	NOUN
dti-1373	161	5	)	)	PUNCT
dti-1373	161	6	resveratrol	resveratrol	VERB
dti-1373	161	7	pre	pre	ADJ
dti-1373	161	8	-	-	ADJ
dti-1373	161	9	treatmentvehicle	treatmentvehicle	ADJ
dti-1373	161	10	pre	pre	NOUN
dti-1373	161	11	-	-	NOUN
dti-1373	161	12	treatment	treatment	ADJ
dti-1373	161	13	c	c	NOUN
dti-1373	161	14	0	0	NUM
dti-1373	161	15	2	2	NUM
dti-1373	161	16	120	120	NUM
dti-1373	161	17	100	100	NUM
dti-1373	161	18	80	80	NUM
dti-1373	161	19	60	60	NUM
dti-1373	161	20	40	40	NUM
dti-1373	161	21	20	20	NUM
dti-1373	161	22	0	0	NUM
dti-1373	161	23	120	120	NUM
dti-1373	161	24	100	100	NUM
dti-1373	161	25	80	80	NUM
dti-1373	161	26	60	60	NUM
dti-1373	161	27	40	40	NUM
dti-1373	161	28	20	20	NUM
dti-1373	161	29	0	0	NUM
dti-1373	161	30	mock	mock	ADJ
dti-1373	161	31	mock	mock	ADJ
dti-1373	161	32	gapdh	gapdh	NOUN
dti-1373	161	33	plκb	plκb	NOUN
dti-1373	161	34	gapdh	gapdh	NOUN
dti-1373	161	35	plκb	plκb	NOUN
dti-1373	161	36	sisirt1	sisirt1	PROPN
dti-1373	161	37	m	m	NOUN
dti-1373	161	38	oc	oc	ADP
dti-1373	161	39	k	k	PROPN
dti-1373	161	40	si	si	PROPN
dti-1373	161	41	s	s	X
dti-1373	161	42	irt	irt	PROPN
dti-1373	161	43	1	1	NUM
dti-1373	161	44	sisirt1	sisirt1	NOUN
dti-1373	161	45	time	time	NOUN
dti-1373	161	46	(	(	PUNCT
dti-1373	161	47	min	min	NOUN
dti-1373	161	48	)	)	PUNCT
dti-1373	161	49	5	5	NUM
dti-1373	161	50	10	10	NUM
dti-1373	161	51	15	15	NUM
dti-1373	161	52	20	20	NUM
dti-1373	161	53	25	25	NUM
dti-1373	161	54	30	30	NUM
dti-1373	161	55	0	0	NUM
dti-1373	161	56	5	5	NUM
dti-1373	161	57	10	10	NUM
dti-1373	161	58	15	15	NUM
dti-1373	161	59	20	20	NUM
dti-1373	161	60	25	25	NUM
dti-1373	161	61	30	30	NUM
dti-1373	161	62	0	0	NUM
dti-1373	161	63	2	2	NUM
dti-1373	161	64	5	5	NUM
dti-1373	161	65	10	10	NUM
dti-1373	161	66	15	15	NUM
dti-1373	161	67	20	20	NUM
dti-1373	161	68	25	25	NUM
dti-1373	161	69	30	30	NUM
dti-1373	161	70	(	(	PUNCT
dti-1373	161	71	min	min	NOUN
dti-1373	161	72	)	)	PUNCT
dti-1373	161	73	figure	figure	NOUN
dti-1373	161	74	5	5	NUM
dti-1373	161	75	.	.	PUNCT
dti-1373	161	76	sirt1	sirt1	NOUN
dti-1373	161	77	contributes	contribute	VERB
dti-1373	161	78	to	to	ADP
dti-1373	161	79	the	the	DET
dti-1373	161	80	resveratrol	resveratrol	NOUN
dti-1373	161	81	inhibitory	inhibitory	ADJ
dti-1373	161	82	effect	effect	NOUN
dti-1373	161	83	of	of	ADP
dti-1373	161	84	pma	pma	NOUN
dti-1373	161	85	-	-	PUNCT
dti-1373	161	86	induced	induce	VERB
dti-1373	161	87	ikb	ikb	PROPN
dti-1373	161	88	phosphorylation	phosphorylation	NOUN
dti-1373	161	89	.	.	PUNCT
dti-1373	162	1	hbmec	hbmec	PROPN
dti-1373	162	2	were	be	AUX
dti-1373	162	3	transiently	transiently	ADV
dti-1373	162	4	transfected	transfecte	VERB
dti-1373	162	5	with	with	ADP
dti-1373	162	6	a	a	DET
dti-1373	162	7	scrambled	scramble	VERB
dti-1373	162	8	sirna	sirna	PROPN
dti-1373	162	9	sequence	sequence	NOUN
dti-1373	162	10	(	(	PUNCT
dti-1373	162	11	mock	mock	ADJ
dti-1373	162	12	)	)	PUNCT
dti-1373	162	13	or	or	CCONJ
dti-1373	162	14	a	a	DET
dti-1373	162	15	sirna	sirna	PROPN
dti-1373	162	16	designed	design	VERB
dti-1373	162	17	to	to	PART
dti-1373	162	18	downregulate	downregulate	VERB
dti-1373	162	19	sirt1	sirt1	PROPN
dti-1373	162	20	(	(	PUNCT
dti-1373	162	21	sisirt1	sisirt1	NOUN
dti-1373	162	22	)	)	PUNCT
dti-1373	162	23	as	as	SCONJ
dti-1373	162	24	described	describe	VERB
dti-1373	162	25	in	in	ADP
dti-1373	162	26	the	the	DET
dti-1373	162	27	methods	method	NOUN
dti-1373	162	28	section	section	NOUN
dti-1373	162	29	.	.	PUNCT
dti-1373	163	1	(	(	PUNCT
dti-1373	163	2	a	a	X
dti-1373	163	3	)	)	PUNCT
dti-1373	163	4	mock	mock	ADJ
dti-1373	163	5	and	and	CCONJ
dti-1373	163	6	sisirt1	sisirt1	NOUN
dti-1373	163	7	-	-	PUNCT
dti-1373	163	8	transfected	transfecte	VERB
dti-1373	163	9	hbmec	hbmec	NOUN
dti-1373	163	10	were	be	AUX
dti-1373	163	11	then	then	ADV
dti-1373	163	12	serum	serum	NOUN
dti-1373	163	13	-	-	PUNCT
dti-1373	163	14	starved	starve	VERB
dti-1373	163	15	for	for	ADP
dti-1373	163	16	30	30	NUM
dti-1373	163	17	minutes	minute	NOUN
dti-1373	163	18	in	in	ADP
dti-1373	163	19	the	the	DET
dti-1373	163	20	presence	presence	NOUN
dti-1373	163	21	or	or	CCONJ
dti-1373	163	22	not	not	PART
dti-1373	163	23	of	of	ADP
dti-1373	163	24	50	50	NUM
dti-1373	163	25	µm	µm	NOUN
dti-1373	163	26	resveratrol	resveratrol	NOUN
dti-1373	163	27	,	,	PUNCT
dti-1373	163	28	then	then	ADV
dti-1373	163	29	treated	treat	VERB
dti-1373	163	30	with	with	ADP
dti-1373	163	31	1	1	NUM
dti-1373	163	32	µm	µm	ADP
dti-1373	163	33	pma	pma	NOUN
dti-1373	163	34	for	for	ADP
dti-1373	163	35	the	the	DET
dti-1373	163	36	indicated	indicate	VERB
dti-1373	163	37	time	time	NOUN
dti-1373	163	38	.	.	PUNCT
dti-1373	164	1	lysates	lysate	NOUN
dti-1373	164	2	were	be	AUX
dti-1373	164	3	isolated	isolate	VERB
dti-1373	164	4	,	,	PUNCT
dti-1373	164	5	electrophoresed	electrophorese	VERB
dti-1373	164	6	via	via	ADP
dti-1373	164	7	sds	sds	NOUN
dti-1373	164	8	-	-	PUNCT
dti-1373	164	9	page	page	NOUN
dti-1373	164	10	and	and	CCONJ
dti-1373	164	11	immunodetection	immunodetection	NOUN
dti-1373	164	12	of	of	ADP
dti-1373	164	13	phosphorylated	phosphorylate	VERB
dti-1373	164	14	iκb	iκb	NOUN
dti-1373	164	15	(	(	PUNCT
dti-1373	164	16	p	p	NOUN
dti-1373	164	17	-	-	PUNCT
dti-1373	164	18	iκb	iκb	NOUN
dti-1373	164	19	)	)	PUNCT
dti-1373	164	20	and	and	CCONJ
dti-1373	164	21	gapdh	gapdh	NOUN
dti-1373	164	22	proteins	protein	NOUN
dti-1373	164	23	was	be	AUX
dti-1373	164	24	performed	perform	VERB
dti-1373	164	25	as	as	SCONJ
dti-1373	164	26	described	describe	VERB
dti-1373	164	27	in	in	ADP
dti-1373	164	28	the	the	DET
dti-1373	164	29	methods	method	NOUN
dti-1373	164	30	section	section	NOUN
dti-1373	164	31	.	.	PUNCT
dti-1373	165	1	(	(	PUNCT
dti-1373	165	2	b	b	X
dti-1373	165	3	)	)	PUNCT
dti-1373	165	4	total	total	ADJ
dti-1373	165	5	rna	rna	NOUN
dti-1373	165	6	isolation	isolation	NOUN
dti-1373	165	7	,	,	PUNCT
dti-1373	165	8	rt	rt	NOUN
dti-1373	165	9	-	-	PUNCT
dti-1373	165	10	pcr	pcr	NOUN
dti-1373	165	11	,	,	PUNCT
dti-1373	165	12	and	and	CCONJ
dti-1373	165	13	qpcr	qpcr	ADV
dti-1373	165	14	were	be	AUX
dti-1373	165	15	performed	perform	VERB
dti-1373	165	16	as	as	SCONJ
dti-1373	165	17	described	describe	VERB
dti-1373	165	18	in	in	ADP
dti-1373	165	19	the	the	DET
dti-1373	165	20	methods	method	NOUN
dti-1373	165	21	section	section	NOUN
dti-1373	165	22	to	to	PART
dti-1373	165	23	assess	assess	VERB
dti-1373	165	24	sirt1	sirt1	NOUN
dti-1373	165	25	gene	gene	NOUN
dti-1373	165	26	expression	expression	NOUN
dti-1373	165	27	in	in	ADP
dti-1373	165	28	the	the	DET
dti-1373	165	29	mock	mock	ADJ
dti-1373	165	30	and	and	CCONJ
dti-1373	165	31	sisirt1	sisirt1	NOUN
dti-1373	165	32	-	-	PUNCT
dti-1373	165	33	transfected	transfecte	VERB
dti-1373	165	34	hbmec	hbmec	NOUN
dti-1373	165	35	.	.	PUNCT
dti-1373	166	1	(	(	PUNCT
dti-1373	166	2	c	c	X
dti-1373	166	3	)	)	PUNCT
dti-1373	166	4	quantification	quantification	NOUN
dti-1373	166	5	was	be	AUX
dti-1373	166	6	performed	perform	VERB
dti-1373	166	7	by	by	ADP
dti-1373	166	8	scanning	scan	VERB
dti-1373	166	9	densitometry	densitometry	NOUN
dti-1373	166	10	of	of	ADP
dti-1373	166	11	the	the	DET
dti-1373	166	12	autoradiograms	autoradiogram	NOUN
dti-1373	166	13	obtained	obtain	VERB
dti-1373	166	14	in	in	ADP
dti-1373	166	15	(	(	PUNCT
dti-1373	166	16	a	a	NOUN
dti-1373	166	17	)	)	PUNCT
dti-1373	166	18	.	.	PUNCT
dti-1373	167	1	notes	note	NOUN
dti-1373	167	2	:	:	PUNCT
dti-1373	167	3	data	datum	NOUN
dti-1373	167	4	were	be	AUX
dti-1373	167	5	expressed	express	VERB
dti-1373	167	6	as	as	ADP
dti-1373	167	7	the	the	DET
dti-1373	167	8	percent	percent	NOUN
dti-1373	167	9	of	of	ADP
dti-1373	167	10	basal	basal	ADJ
dti-1373	167	11	phospho	phospho	ADJ
dti-1373	167	12	-	-	PUNCT
dti-1373	167	13	iκb	iκb	NOUN
dti-1373	167	14	/	/	SYM
dti-1373	167	15	gapdh	gapdh	NOUN
dti-1373	167	16	ratios	ratio	NOUN
dti-1373	167	17	in	in	ADP
dti-1373	167	18	vehicle	vehicle	NOUN
dti-1373	167	19	(	(	PUNCT
dti-1373	167	20	open	open	ADJ
dti-1373	167	21	circles	circle	NOUN
dti-1373	167	22	)	)	PUNCT
dti-1373	167	23	and	and	CCONJ
dti-1373	167	24	resveratrol	resveratrol	NOUN
dti-1373	167	25	pre	pre	ADJ
dti-1373	167	26	-	-	ADJ
dti-1373	167	27	treated	treat	VERB
dti-1373	167	28	cells	cell	NOUN
dti-1373	167	29	(	(	PUNCT
dti-1373	167	30	closed	closed	ADJ
dti-1373	167	31	circles	circle	NOUN
dti-1373	167	32	)	)	PUNCT
dti-1373	167	33	.	.	PUNCT
dti-1373	168	1	densitometric	densitometric	ADJ
dti-1373	168	2	data	datum	NOUN
dti-1373	168	3	of	of	ADP
dti-1373	168	4	a	a	DET
dti-1373	168	5	representative	representative	ADJ
dti-1373	168	6	blot	blot	NOUN
dti-1373	168	7	out	out	ADP
dti-1373	168	8	of	of	ADP
dti-1373	168	9	three	three	NUM
dti-1373	168	10	is	be	AUX
dti-1373	168	11	shown	show	VERB
dti-1373	168	12	.	.	PUNCT
dti-1373	169	1	to	to	PART
dti-1373	169	2	induce	induce	VERB
dti-1373	169	3	deacetylation	deacetylation	NOUN
dti-1373	169	4	of	of	ADP
dti-1373	169	5	known	know	VERB
dti-1373	169	6	sirt1	sirt1	NOUN
dti-1373	169	7	substrates	substrate	NOUN
dti-1373	169	8	such	such	ADJ
dti-1373	169	9	as	as	ADP
dti-1373	169	10	nf	nf	NOUN
dti-1373	169	11	-	-	PUNCT
dti-1373	169	12	κb	κb	ADJ
dti-1373	169	13	,	,	PUNCT
dti-1373	169	14	pgc-1α	pgc-1α	NOUN
dti-1373	169	15	,	,	PUNCT
dti-1373	169	16	and	and	CCONJ
dti-1373	169	17	p53,37,38	p53,37,38	PROPN
dti-1373	169	18	one	one	NOUN
dti-1373	169	19	may	may	AUX
dti-1373	169	20	now	now	ADV
dti-1373	169	21	have	have	VERB
dti-1373	169	22	to	to	PART
dti-1373	169	23	consider	consider	VERB
dti-1373	169	24	alternate	alternate	ADJ
dti-1373	169	25	mechanisms	mechanism	NOUN
dti-1373	169	26	of	of	ADP
dti-1373	169	27	resveratrol	resveratrol	NOUN
dti-1373	169	28	to	to	ADP
dti-1373	169	29	those	those	PRON
dti-1373	169	30	mediated	mediate	VERB
dti-1373	169	31	through	through	ADP
dti-1373	169	32	sirt1	sirt1	NOUN
dti-1373	169	33	.	.	PUNCT
dti-1373	170	1	among	among	ADP
dti-1373	170	2	those	those	DET
dti-1373	170	3	mechanisms	mechanism	NOUN
dti-1373	170	4	,	,	PUNCT
dti-1373	170	5	several	several	ADJ
dti-1373	170	6	flavonoids	flavonoid	NOUN
dti-1373	170	7	have	have	AUX
dti-1373	170	8	been	be	AUX
dti-1373	170	9	reported	report	VERB
dti-1373	170	10	to	to	PART
dti-1373	170	11	interfere	interfere	VERB
dti-1373	170	12	with	with	ADP
dti-1373	170	13	the	the	DET
dti-1373	170	14	inducible	inducible	ADJ
dti-1373	170	15	nitric	nitric	ADJ
dti-1373	170	16	-	-	PUNCT
dti-1373	170	17	oxide	oxide	NOUN
dti-1373	170	18	synthase	synthase	NOUN
dti-1373	170	19	activity	activity	NOUN
dti-1373	170	20	,	,	PUNCT
dti-1373	170	21	as	as	ADV
dti-1373	170	22	well	well	ADV
dti-1373	170	23	as	as	ADP
dti-1373	170	24	of	of	ADP
dti-1373	170	25	both	both	CCONJ
dti-1373	170	26	the	the	DET
dti-1373	170	27	cox	cox	PROPN
dti-1373	170	28	and	and	CCONJ
dti-1373	170	29	5	5	NUM
dti-1373	170	30	-	-	PUNCT
dti-1373	170	31	lipoxygenase	lipoxygenase	NOUN
dti-1373	170	32	pathways.39,40	pathways.39,40	NOUN
dti-1373	170	33	interestingly	interestingly	ADV
dti-1373	170	34	,	,	PUNCT
dti-1373	170	35	sirt1	sirt1	NOUN
dti-1373	170	36	is	be	AUX
dti-1373	170	37	a	a	DET
dti-1373	170	38	putative	putative	ADJ
dti-1373	170	39	suppressive	suppressive	ADJ
dti-1373	170	40	regulator	regulator	NOUN
dti-1373	170	41	found	find	VERB
dti-1373	170	42	in	in	ADP
dti-1373	170	43	the	the	DET
dti-1373	170	44	mmp-9	mmp-9	ADJ
dti-1373	170	45	gene	gene	NOUN
dti-1373	170	46	promoter,41	promoter,41	NOUN
dti-1373	170	47	and	and	CCONJ
dti-1373	170	48	activation	activation	NOUN
dti-1373	170	49	of	of	ADP
dti-1373	170	50	sirt1	sirt1	NOUN
dti-1373	170	51	by	by	ADP
dti-1373	170	52	resveratrol	resveratrol	NOUN
dti-1373	170	53	was	be	AUX
dti-1373	170	54	found	find	VERB
dti-1373	170	55	to	to	PART
dti-1373	170	56	be	be	AUX
dti-1373	170	57	required	require	VERB
dti-1373	170	58	for	for	ADP
dti-1373	170	59	inhibition	inhibition	NOUN
dti-1373	170	60	of	of	ADP
dti-1373	170	61	pma	pma	NOUN
dti-1373	170	62	-	-	PUNCT
dti-1373	170	63	induced	induce	VERB
dti-1373	170	64	mmp-9	mmp-9	NOUN
dti-1373	170	65	expression.42,43	expression.42,43	ADJ
dti-1373	170	66	generalized	generalize	VERB
dti-1373	170	67	interpretation	interpretation	NOUN
dti-1373	170	68	,	,	PUNCT
dti-1373	170	69	in	in	ADP
dti-1373	170	70	part	part	NOUN
dti-1373	170	71	due	due	ADP
dti-1373	170	72	to	to	ADP
dti-1373	170	73	the	the	DET
dti-1373	170	74	occurrence	occurrence	NOUN
dti-1373	170	75	of	of	ADP
dti-1373	170	76	multiple	multiple	ADJ
dti-1373	170	77	in	in	ADP
dti-1373	170	78	vitro	vitro	X
dti-1373	170	79	cell	cell	NOUN
dti-1373	170	80	culture	culture	NOUN
dti-1373	170	81	models	model	NOUN
dti-1373	170	82	,	,	PUNCT
dti-1373	170	83	has	have	AUX
dti-1373	170	84	put	put	VERB
dti-1373	170	85	forward	forward	ADV
dti-1373	170	86	large	large	ADJ
dti-1373	170	87	number	number	NOUN
dti-1373	170	88	of	of	ADP
dti-1373	170	89	mechanisms	mechanism	NOUN
dti-1373	170	90	of	of	ADP
dti-1373	170	91	action	action	NOUN
dti-1373	170	92	attributed	attribute	VERB
dti-1373	170	93	to	to	ADP
dti-1373	170	94	flavonoids	flavonoid	NOUN
dti-1373	170	95	commonly	commonly	ADV
dti-1373	170	96	found	find	VERB
dti-1373	170	97	in	in	ADP
dti-1373	170	98	fruits	fruit	NOUN
dti-1373	170	99	,	,	PUNCT
dti-1373	170	100	vegetables	vegetable	NOUN
dti-1373	170	101	,	,	PUNCT
dti-1373	170	102	wine	wine	NOUN
dti-1373	170	103	,	,	PUNCT
dti-1373	170	104	or	or	CCONJ
dti-1373	170	105	tea	tea	NOUN
dti-1373	170	106	as	as	ADP
dti-1373	170	107	their	their	PRON
dti-1373	170	108	metabolites	metabolite	NOUN
dti-1373	170	109	also	also	ADV
dti-1373	170	110	can	can	AUX
dti-1373	170	111	act	act	VERB
dti-1373	170	112	http://www.la-press.com	http://www.la-press.com	X
dti-1373	170	113	sirt1	sirt1	NOUN
dti-1373	170	114	expression	expression	NOUN
dti-1373	170	115	in	in	ADP
dti-1373	170	116	inflammatory	inflammatory	ADJ
dti-1373	170	117	cerebral	cerebral	ADJ
dti-1373	170	118	endothelium	endothelium	NOUN
dti-1373	170	119	drug	drug	NOUN
dti-1373	170	120	target	target	NOUN
dti-1373	170	121	insights	insight	NOUN
dti-1373	170	122	2012:6	2012:6	NUM
dti-1373	170	123	9	9	NUM
dti-1373	170	124	as	as	ADP
dti-1373	170	125	potent	potent	ADJ
dti-1373	170	126	antioxidants	antioxidant	NOUN
dti-1373	170	127	and	and	CCONJ
dti-1373	170	128	free	free	ADJ
dti-1373	170	129	radical	radical	ADJ
dti-1373	170	130	scavengers.21,44	scavengers.21,44	NOUN
dti-1373	170	131	whether	whether	SCONJ
dti-1373	170	132	the	the	DET
dti-1373	170	133	inhibitory	inhibitory	ADJ
dti-1373	170	134	effects	effect	NOUN
dti-1373	170	135	observed	observe	VERB
dti-1373	170	136	in	in	ADP
dti-1373	170	137	vitro	vitro	X
dti-1373	170	138	are	be	AUX
dti-1373	170	139	due	due	ADJ
dti-1373	170	140	to	to	PART
dti-1373	170	141	resveratrol	resveratrol	NOUN
dti-1373	170	142	metabolites	metabolite	NOUN
dti-1373	170	143	has	have	AUX
dti-1373	170	144	therefore	therefore	ADV
dti-1373	170	145	to	to	PART
dti-1373	170	146	be	be	AUX
dti-1373	170	147	promptly	promptly	ADV
dti-1373	170	148	considered	consider	VERB
dti-1373	170	149	and	and	CCONJ
dti-1373	170	150	carefully	carefully	ADV
dti-1373	170	151	addressed	address	VERB
dti-1373	170	152	.	.	PUNCT
dti-1373	171	1	as	as	SCONJ
dti-1373	171	2	such	such	ADJ
dti-1373	171	3	,	,	PUNCT
dti-1373	171	4	oral	oral	ADJ
dti-1373	171	5	bioavailability	bioavailability	NOUN
dti-1373	171	6	of	of	ADP
dti-1373	171	7	resveratrol	resveratrol	NOUN
dti-1373	171	8	has	have	AUX
dti-1373	171	9	been	be	AUX
dti-1373	171	10	reported	report	VERB
dti-1373	171	11	to	to	PART
dti-1373	171	12	be	be	AUX
dti-1373	171	13	low	low	ADJ
dti-1373	171	14	because	because	SCONJ
dti-1373	171	15	it	it	PRON
dti-1373	171	16	is	be	AUX
dti-1373	171	17	rapidly	rapidly	ADV
dti-1373	171	18	metabolized	metabolize	VERB
dti-1373	171	19	in	in	ADP
dti-1373	171	20	intestines	intestine	NOUN
dti-1373	171	21	and	and	CCONJ
dti-1373	171	22	liver	liver	NOUN
dti-1373	171	23	into	into	ADP
dti-1373	171	24	conjugated	conjugate	VERB
dti-1373	171	25	forms	form	NOUN
dti-1373	171	26	such	such	ADJ
dti-1373	171	27	as	as	ADP
dti-1373	171	28	glucuronate	glucuronate	ADJ
dti-1373	171	29	and	and	CCONJ
dti-1373	171	30	sulfonate.45	sulfonate.45	ADV
dti-1373	171	31	in	in	ADP
dti-1373	171	32	mammals	mammal	NOUN
dti-1373	171	33	,	,	PUNCT
dti-1373	171	34	less	less	ADJ
dti-1373	171	35	than	than	ADP
dti-1373	171	36	5	5	NUM
dti-1373	171	37	%	%	NOUN
dti-1373	171	38	of	of	ADP
dti-1373	171	39	the	the	DET
dti-1373	171	40	oral	oral	ADJ
dti-1373	171	41	dose	dose	NOUN
dti-1373	171	42	is	be	AUX
dti-1373	171	43	being	be	AUX
dti-1373	171	44	observed	observe	VERB
dti-1373	171	45	as	as	ADP
dti-1373	171	46	free	free	ADJ
dti-1373	171	47	resveratrol	resveratrol	NOUN
dti-1373	171	48	in	in	ADP
dti-1373	171	49	blood	blood	NOUN
dti-1373	171	50	plasma.45–47	plasma.45–47	VERB
dti-1373	171	51	the	the	DET
dti-1373	171	52	most	most	ADV
dti-1373	171	53	abundant	abundant	ADJ
dti-1373	171	54	resveratrol	resveratrol	NOUN
dti-1373	171	55	metabolites	metabolite	NOUN
dti-1373	171	56	being	be	AUX
dti-1373	171	57	trans	tran	NOUN
dti-1373	171	58	-	-	ADJ
dti-1373	171	59	resveratrol-3	resveratrol-3	ADJ
dti-1373	171	60	-	-	PUNCT
dti-1373	171	61	o	o	NOUN
dti-1373	171	62	-	-	ADJ
dti-1373	171	63	glucuronide	glucuronide	ADJ
dti-1373	171	64	and	and	CCONJ
dti-1373	171	65	transresveratrol-3	transresveratrol-3	NUM
dti-1373	171	66	-	-	PUNCT
dti-1373	171	67	sulfate,48	sulfate,48	NOUN
dti-1373	171	68	the	the	DET
dti-1373	171	69	impact	impact	NOUN
dti-1373	171	70	of	of	ADP
dti-1373	171	71	glucuronides	glucuronide	NOUN
dti-1373	171	72	and	and	CCONJ
dti-1373	171	73	of	of	ADP
dti-1373	171	74	these	these	DET
dti-1373	171	75	sulfate	sulfate	NOUN
dti-1373	171	76	conjugates	conjugate	NOUN
dti-1373	171	77	will	will	AUX
dti-1373	171	78	also	also	ADV
dti-1373	171	79	ultimately	ultimately	ADV
dti-1373	171	80	need	need	VERB
dti-1373	171	81	further	further	ADJ
dti-1373	171	82	study	study	NOUN
dti-1373	171	83	.	.	PUNCT
dti-1373	172	1	in	in	ADP
dti-1373	172	2	summary	summary	NOUN
dti-1373	172	3	,	,	PUNCT
dti-1373	172	4	the	the	DET
dti-1373	172	5	present	present	ADJ
dti-1373	172	6	study	study	NOUN
dti-1373	172	7	has	have	AUX
dti-1373	172	8	confirmed	confirm	VERB
dti-1373	172	9	resveratrol	resveratrol	NOUN
dti-1373	172	10	as	as	ADP
dti-1373	172	11	a	a	DET
dti-1373	172	12	signal	signal	ADJ
dti-1373	172	13	transduction	transduction	NOUN
dti-1373	172	14	inhibitor	inhibitor	NOUN
dti-1373	172	15	against	against	ADP
dti-1373	172	16	carcinogen	carcinogen	NOUN
dti-1373	172	17	-	-	PUNCT
dti-1373	172	18	mediated	mediate	VERB
dti-1373	172	19	induction	induction	NOUN
dti-1373	172	20	of	of	ADP
dti-1373	172	21	cox-2	cox-2	NOUN
dti-1373	172	22	and	and	CCONJ
dti-1373	172	23	mmp-9	mmp-9	NOUN
dti-1373	172	24	.	.	PUNCT
dti-1373	173	1	moreover	moreover	ADV
dti-1373	173	2	,	,	PUNCT
dti-1373	173	3	evidence	evidence	NOUN
dti-1373	173	4	that	that	SCONJ
dti-1373	173	5	the	the	DET
dti-1373	173	6	nf	nf	ADJ
dti-1373	173	7	-	-	PUNCT
dti-1373	173	8	κb	κb	NOUN
dti-1373	173	9	pathway	pathway	NOUN
dti-1373	173	10	may	may	AUX
dti-1373	173	11	be	be	AUX
dti-1373	173	12	inhibited	inhibit	VERB
dti-1373	173	13	through	through	ADP
dti-1373	173	14	the	the	DET
dti-1373	173	15	targeting	targeting	NOUN
dti-1373	173	16	of	of	ADP
dti-1373	173	17	iκk	iκk	ADJ
dti-1373	173	18	phosphorylation	phosphorylation	NOUN
dti-1373	173	19	capacity	capacity	NOUN
dti-1373	173	20	that	that	PRON
dti-1373	173	21	ultimately	ultimately	ADV
dti-1373	173	22	may	may	AUX
dti-1373	173	23	reduce	reduce	VERB
dti-1373	173	24	both	both	DET
dti-1373	173	25	the	the	DET
dti-1373	173	26	acquisition	acquisition	NOUN
dti-1373	173	27	of	of	ADP
dti-1373	173	28	a	a	DET
dti-1373	173	29	pro	pro	ADJ
dti-1373	173	30	-	-	ADJ
dti-1373	173	31	inflammatory	inflammatory	ADJ
dti-1373	173	32	phenotype	phenotype	NOUN
dti-1373	173	33	,	,	PUNCT
dti-1373	173	34	as	as	SCONJ
dti-1373	173	35	reflected	reflect	VERB
dti-1373	173	36	by	by	ADP
dti-1373	173	37	decreased	decrease	VERB
dti-1373	173	38	cox-2	cox-2	ADJ
dti-1373	173	39	expression	expression	NOUN
dti-1373	173	40	,	,	PUNCT
dti-1373	173	41	and	and	CCONJ
dti-1373	173	42	the	the	DET
dti-1373	173	43	acquisition	acquisition	NOUN
dti-1373	173	44	of	of	ADP
dti-1373	173	45	pro	pro	ADJ
dti-1373	173	46	-	-	ADJ
dti-1373	173	47	angiogenic	angiogenic	ADJ
dti-1373	173	48	phenotype	phenotype	NOUN
dti-1373	173	49	,	,	PUNCT
dti-1373	173	50	as	as	SCONJ
dti-1373	173	51	reflected	reflect	VERB
dti-1373	173	52	by	by	ADP
dti-1373	173	53	a	a	DET
dti-1373	173	54	decrease	decrease	NOUN
dti-1373	173	55	in	in	ADP
dti-1373	173	56	mmp-9	mmp-9	ADJ
dti-1373	173	57	.	.	PUNCT
dti-1373	174	1	our	our	PRON
dti-1373	174	2	results	result	NOUN
dti-1373	174	3	further	far	ADV
dti-1373	174	4	discriminate	discriminate	VERB
dti-1373	174	5	the	the	DET
dti-1373	174	6	role	role	NOUN
dti-1373	174	7	of	of	ADP
dti-1373	174	8	sirt1	sirt1	NOUN
dti-1373	174	9	in	in	ADP
dti-1373	174	10	the	the	DET
dti-1373	174	11	anti	anti	ADJ
dti-1373	174	12	-	-	ADJ
dti-1373	174	13	pma	pma	ADJ
dti-1373	174	14	action	action	NOUN
dti-1373	174	15	of	of	ADP
dti-1373	174	16	resveratrol	resveratrol	NOUN
dti-1373	174	17	suggesting	suggest	VERB
dti-1373	174	18	alternative	alternative	ADJ
dti-1373	174	19	intracellular	intracellular	ADJ
dti-1373	174	20	targeting	targeting	NOUN
dti-1373	174	21	.	.	PUNCT
dti-1373	175	1	whether	whether	SCONJ
dti-1373	175	2	other	other	ADJ
dti-1373	175	3	sirtuin	sirtuin	NOUN
dti-1373	175	4	members	member	NOUN
dti-1373	175	5	are	be	AUX
dti-1373	175	6	involved	involve	VERB
dti-1373	175	7	remains	remain	VERB
dti-1373	175	8	to	to	PART
dti-1373	175	9	be	be	AUX
dti-1373	175	10	investigated	investigate	VERB
dti-1373	175	11	.	.	PUNCT
dti-1373	176	1	bbb	bbb	NOUN
dti-1373	176	2	disruption	disruption	NOUN
dti-1373	176	3	during	during	ADP
dti-1373	176	4	neuroinflammation	neuroinflammation	NOUN
dti-1373	176	5	may	may	AUX
dti-1373	176	6	,	,	PUNCT
dti-1373	176	7	in	in	ADP
dti-1373	176	8	light	light	NOUN
dti-1373	176	9	of	of	ADP
dti-1373	176	10	our	our	PRON
dti-1373	176	11	results	result	NOUN
dti-1373	176	12	,	,	PUNCT
dti-1373	176	13	be	be	AUX
dti-1373	176	14	pharmacologically	pharmacologically	ADV
dti-1373	176	15	reduced	reduce	VERB
dti-1373	176	16	by	by	ADP
dti-1373	176	17	a	a	DET
dti-1373	176	18	specific	specific	ADJ
dti-1373	176	19	class	class	NOUN
dti-1373	176	20	of	of	ADP
dti-1373	176	21	flavonoids	flavonoid	NOUN
dti-1373	176	22	acting	act	VERB
dti-1373	176	23	as	as	ADP
dti-1373	176	24	nf	nf	ADJ
dti-1373	176	25	-	-	PUNCT
dti-1373	176	26	κb	κb	ADJ
dti-1373	176	27	signal	signal	ADJ
dti-1373	176	28	transduction	transduction	NOUN
dti-1373	176	29	inhibitors	inhibitor	NOUN
dti-1373	176	30	.	.	PUNCT
dti-1373	177	1	list	list	NOUN
dti-1373	177	2	of	of	ADP
dti-1373	177	3	abbreviations	abbreviation	NOUN
dti-1373	177	4	bbb	bbb	NOUN
dti-1373	177	5	,	,	PUNCT
dti-1373	177	6	blood	blood	NOUN
dti-1373	177	7	-	-	PUNCT
dti-1373	177	8	brain	brain	NOUN
dti-1373	177	9	barrier	barrier	NOUN
dti-1373	177	10	;	;	PUNCT
dti-1373	177	11	cox	cox	PROPN
dti-1373	177	12	,	,	PUNCT
dti-1373	177	13	cyclooxygenase	cyclooxygenase	PROPN
dti-1373	177	14	;	;	PUNCT
dti-1373	177	15	ec	ec	PROPN
dti-1373	177	16	,	,	PUNCT
dti-1373	177	17	endothelial	endothelial	ADJ
dti-1373	177	18	cells	cell	NOUN
dti-1373	177	19	;	;	PUNCT
dti-1373	177	20	er	er	INTJ
dti-1373	177	21	,	,	PUNCT
dti-1373	177	22	endoplasmic	endoplasmic	ADJ
dti-1373	177	23	reticulum	reticulum	NOUN
dti-1373	177	24	;	;	PUNCT
dti-1373	177	25	mmp-9	mmp-9	NUM
dti-1373	177	26	,	,	PUNCT
dti-1373	177	27	matrix	matrix	NOUN
dti-1373	177	28	metalloproteinase-9	metalloproteinase-9	NUM
dti-1373	177	29	;	;	PUNCT
dti-1373	177	30	nf	nf	NOUN
dti-1373	177	31	-	-	PUNCT
dti-1373	177	32	κb	κb	ADJ
dti-1373	177	33	,	,	PUNCT
dti-1373	177	34	nuclear	nuclear	ADJ
dti-1373	177	35	factor	factor	NOUN
dti-1373	177	36	-	-	PUNCT
dti-1373	177	37	kappa	kappa	PROPN
dti-1373	177	38	b	b	PROPN
dti-1373	177	39	;	;	PUNCT
dti-1373	177	40	pma	pma	PROPN
dti-1373	177	41	,	,	PUNCT
dti-1373	177	42	phorbol	phorbol	NOUN
dti-1373	177	43	12	12	NUM
dti-1373	177	44	-	-	PUNCT
dti-1373	177	45	myristate	myristate	ADJ
dti-1373	177	46	13	13	NUM
dti-1373	177	47	-	-	PUNCT
dti-1373	177	48	acetate	acetate	NOUN
dti-1373	177	49	.	.	PUNCT
dti-1373	178	1	authors	author	NOUN
dti-1373	178	2	’	'	PUNCT
dti-1373	178	3	contributions	contribution	NOUN
dti-1373	178	4	ba	ba	PROPN
dti-1373	178	5	has	have	AUX
dti-1373	178	6	conceived	conceive	VERB
dti-1373	178	7	,	,	PUNCT
dti-1373	178	8	designed	design	VERB
dti-1373	178	9	,	,	PUNCT
dti-1373	178	10	analyzed	analyze	VERB
dti-1373	178	11	and	and	CCONJ
dti-1373	178	12	interpreted	interpret	VERB
dti-1373	178	13	the	the	DET
dti-1373	178	14	data	datum	NOUN
dti-1373	178	15	of	of	ADP
dti-1373	178	16	this	this	DET
dti-1373	178	17	study	study	NOUN
dti-1373	178	18	.	.	PUNCT
dti-1373	179	1	sld	sld	PROPN
dti-1373	179	2	has	have	AUX
dti-1373	179	3	acquired	acquire	VERB
dti-1373	179	4	,	,	PUNCT
dti-1373	179	5	analyzed	analyze	VERB
dti-1373	179	6	,	,	PUNCT
dti-1373	179	7	and	and	CCONJ
dti-1373	179	8	was	be	AUX
dti-1373	179	9	involved	involve	VERB
dti-1373	179	10	in	in	ADP
dti-1373	179	11	drafting	draft	VERB
dti-1373	179	12	the	the	DET
dti-1373	179	13	manuscript	manuscript	NOUN
dti-1373	179	14	.	.	PUNCT
dti-1373	180	1	av	av	PROPN
dti-1373	180	2	has	have	AUX
dti-1373	180	3	acquired	acquire	VERB
dti-1373	180	4	and	and	CCONJ
dti-1373	180	5	analyzed	analyze	VERB
dti-1373	180	6	the	the	DET
dti-1373	180	7	data	datum	NOUN
dti-1373	180	8	.	.	PUNCT
dti-1373	181	1	rb	rb	PROPN
dti-1373	181	2	has	have	AUX
dti-1373	181	3	conceived	conceive	VERB
dti-1373	181	4	,	,	PUNCT
dti-1373	181	5	designed	design	VERB
dti-1373	181	6	,	,	PUNCT
dti-1373	181	7	supported	support	VERB
dti-1373	181	8	financially	financially	ADV
dti-1373	181	9	this	this	DET
dti-1373	181	10	study	study	NOUN
dti-1373	181	11	,	,	PUNCT
dti-1373	181	12	and	and	CCONJ
dti-1373	181	13	was	be	AUX
dti-1373	181	14	involved	involve	VERB
dti-1373	181	15	in	in	ADP
dti-1373	181	16	drafting	draft	VERB
dti-1373	181	17	the	the	DET
dti-1373	181	18	manuscript	manuscript	NOUN
dti-1373	181	19	.	.	PUNCT
dti-1373	182	1	all	all	DET
dti-1373	182	2	authors	author	NOUN
dti-1373	182	3	read	read	VERB
dti-1373	182	4	and	and	CCONJ
dti-1373	182	5	approved	approve	VERB
dti-1373	182	6	the	the	DET
dti-1373	182	7	final	final	ADJ
dti-1373	182	8	version	version	NOUN
dti-1373	182	9	of	of	ADP
dti-1373	182	10	this	this	DET
dti-1373	182	11	manuscript	manuscript	NOUN
dti-1373	182	12	.	.	PUNCT
dti-1373	183	1	competing	compete	VERB
dti-1373	183	2	interests	interest	NOUN
dti-1373	183	3	ba	ba	PROPN
dti-1373	183	4	holds	hold	VERB
dti-1373	183	5	a	a	DET
dti-1373	183	6	canada	canada	PROPN
dti-1373	183	7	research	research	NOUN
dti-1373	183	8	chair	chair	NOUN
dti-1373	183	9	in	in	ADP
dti-1373	183	10	molecular	molecular	ADJ
dti-1373	183	11	and	and	CCONJ
dti-1373	183	12	metabolic	metabolic	NOUN
dti-1373	183	13	oncology	oncology	NOUN
dti-1373	183	14	from	from	ADP
dti-1373	183	15	the	the	DET
dti-1373	183	16	canadian	canadian	ADJ
dti-1373	183	17	institutes	institutes	PROPN
dti-1373	183	18	of	of	ADP
dti-1373	183	19	health	health	PROPN
dti-1373	183	20	research	research	NOUN
dti-1373	183	21	(	(	PUNCT
dti-1373	183	22	cihr	cihr	VERB
dti-1373	183	23	)	)	PUNCT
dti-1373	183	24	.	.	PUNCT
dti-1373	184	1	rb	rb	PROPN
dti-1373	184	2	holds	hold	VERB
dti-1373	184	3	an	an	DET
dti-1373	184	4	institutional	institutional	ADJ
dti-1373	184	5	uqam	uqam	PROPN
dti-1373	184	6	research	research	NOUN
dti-1373	184	7	chair	chair	NOUN
dti-1373	184	8	in	in	ADP
dti-1373	184	9	cancer	cancer	NOUN
dti-1373	184	10	prevention	prevention	NOUN
dti-1373	184	11	and	and	CCONJ
dti-1373	184	12	treatment	treatment	NOUN
dti-1373	184	13	.	.	PUNCT
dti-1373	185	1	funding	fund	VERB
dti-1373	185	2	this	this	DET
dti-1373	185	3	study	study	NOUN
dti-1373	185	4	was	be	AUX
dti-1373	185	5	funded	fund	VERB
dti-1373	185	6	by	by	ADP
dti-1373	185	7	grants	grant	NOUN
dti-1373	185	8	from	from	ADP
dti-1373	185	9	the	the	DET
dti-1373	185	10	natural	natural	ADJ
dti-1373	185	11	sciences	science	NOUN
dti-1373	185	12	and	and	CCONJ
dti-1373	185	13	engineering	engineering	NOUN
dti-1373	185	14	research	research	NOUN
dti-1373	185	15	council	council	PROPN
dti-1373	185	16	of	of	ADP
dti-1373	185	17	canada	canada	PROPN
dti-1373	185	18	(	(	PUNCT
dti-1373	185	19	nserc	nserc	PROPN
dti-1373	185	20	)	)	PUNCT
dti-1373	185	21	to	to	PART
dti-1373	185	22	rb	rb	VERB
dti-1373	185	23	.	.	PUNCT
dti-1373	185	24	disclosures	disclosure	NOUN
dti-1373	185	25	and	and	CCONJ
dti-1373	185	26	ethics	ethic	NOUN
dti-1373	185	27	as	as	ADP
dti-1373	185	28	a	a	DET
dti-1373	185	29	requirement	requirement	NOUN
dti-1373	185	30	of	of	ADP
dti-1373	185	31	publication	publication	NOUN
dti-1373	185	32	author(s	author(s	PROPN
dti-1373	185	33	)	)	PUNCT
dti-1373	185	34	have	have	AUX
dti-1373	185	35	provided	provide	VERB
dti-1373	185	36	to	to	ADP
dti-1373	185	37	the	the	DET
dti-1373	185	38	publisher	publisher	NOUN
dti-1373	185	39	signed	sign	VERB
dti-1373	185	40	confirmation	confirmation	NOUN
dti-1373	185	41	of	of	ADP
dti-1373	185	42	compliance	compliance	NOUN
dti-1373	185	43	with	with	ADP
dti-1373	185	44	legal	legal	ADJ
dti-1373	185	45	and	and	CCONJ
dti-1373	185	46	ethical	ethical	ADJ
dti-1373	185	47	obligations	obligation	NOUN
dti-1373	185	48	including	include	VERB
dti-1373	185	49	but	but	CCONJ
dti-1373	185	50	not	not	PART
dti-1373	185	51	limited	limit	VERB
dti-1373	185	52	to	to	ADP
dti-1373	185	53	the	the	DET
dti-1373	185	54	following	following	NOUN
dti-1373	185	55	:	:	PUNCT
dti-1373	185	56	authorship	authorship	NOUN
dti-1373	185	57	and	and	CCONJ
dti-1373	185	58	contributorship	contributorship	NOUN
dti-1373	185	59	,	,	PUNCT
dti-1373	185	60	conflicts	conflict	NOUN
dti-1373	185	61	of	of	ADP
dti-1373	185	62	interest	interest	NOUN
dti-1373	185	63	,	,	PUNCT
dti-1373	185	64	privacy	privacy	NOUN
dti-1373	185	65	and	and	CCONJ
dti-1373	185	66	confidentiality	confidentiality	NOUN
dti-1373	185	67	and	and	CCONJ
dti-1373	185	68	(	(	PUNCT
dti-1373	185	69	where	where	SCONJ
dti-1373	185	70	applicable	applicable	ADJ
dti-1373	185	71	)	)	PUNCT
dti-1373	185	72	protection	protection	NOUN
dti-1373	185	73	of	of	ADP
dti-1373	185	74	human	human	ADJ
dti-1373	185	75	and	and	CCONJ
dti-1373	185	76	animal	animal	NOUN
dti-1373	185	77	research	research	NOUN
dti-1373	185	78	subjects	subject	NOUN
dti-1373	185	79	.	.	PUNCT
dti-1373	186	1	the	the	DET
dti-1373	186	2	authors	author	NOUN
dti-1373	186	3	have	have	AUX
dti-1373	186	4	read	read	VERB
dti-1373	186	5	and	and	CCONJ
dti-1373	186	6	confirmed	confirm	VERB
dti-1373	186	7	their	their	PRON
dti-1373	186	8	agreement	agreement	NOUN
dti-1373	186	9	with	with	ADP
dti-1373	186	10	the	the	DET
dti-1373	186	11	icmje	icmje	NOUN
dti-1373	186	12	authorship	authorship	NOUN
dti-1373	186	13	and	and	CCONJ
dti-1373	186	14	conflict	conflict	NOUN
dti-1373	186	15	of	of	ADP
dti-1373	186	16	interest	interest	NOUN
dti-1373	186	17	criteria	criterion	NOUN
dti-1373	186	18	.	.	PUNCT
dti-1373	187	1	the	the	DET
dti-1373	187	2	authors	author	NOUN
dti-1373	187	3	have	have	AUX
dti-1373	187	4	also	also	ADV
dti-1373	187	5	confirmed	confirm	VERB
dti-1373	187	6	that	that	SCONJ
dti-1373	187	7	this	this	DET
dti-1373	187	8	article	article	NOUN
dti-1373	187	9	is	be	AUX
dti-1373	187	10	unique	unique	ADJ
dti-1373	187	11	and	and	CCONJ
dti-1373	187	12	not	not	PART
dti-1373	187	13	under	under	ADP
dti-1373	187	14	consideration	consideration	NOUN
dti-1373	187	15	or	or	CCONJ
dti-1373	187	16	published	publish	VERB
dti-1373	187	17	in	in	ADP
dti-1373	187	18	any	any	DET
dti-1373	187	19	other	other	ADJ
dti-1373	187	20	publication	publication	NOUN
dti-1373	187	21	,	,	PUNCT
dti-1373	187	22	and	and	CCONJ
dti-1373	187	23	that	that	SCONJ
dti-1373	187	24	they	they	PRON
dti-1373	187	25	have	have	VERB
dti-1373	187	26	permission	permission	NOUN
dti-1373	187	27	from	from	ADP
dti-1373	187	28	rights	right	NOUN
dti-1373	187	29	holders	holder	NOUN
dti-1373	187	30	to	to	PART
dti-1373	187	31	reproduce	reproduce	VERB
dti-1373	187	32	any	any	DET
dti-1373	187	33	copyrighted	copyright	VERB
dti-1373	187	34	material	material	NOUN
dti-1373	187	35	.	.	PUNCT
dti-1373	188	1	any	any	DET
dti-1373	188	2	disclosures	disclosure	NOUN
dti-1373	188	3	are	be	AUX
dti-1373	188	4	made	make	VERB
dti-1373	188	5	in	in	ADP
dti-1373	188	6	this	this	DET
dti-1373	188	7	section	section	NOUN
dti-1373	188	8	.	.	PUNCT
dti-1373	189	1	mock	mock	ADJ
dti-1373	189	2	−	−	PROPN
dti-1373	189	3	−	−	NOUN
dti-1373	189	4	−	−	PROPN
dti-1373	190	1	+	+	CCONJ
dti-1373	191	1	+	+	CCONJ
dti-1373	191	2	−	−	X
dti-1373	191	3	+	+	CCONJ
dti-1373	191	4	−	−	PROPN
dti-1373	192	1	+	+	CCONJ
dti-1373	192	2	−	−	PROPN
dti-1373	193	1	+	+	CCONJ
dti-1373	194	1	+	+	NUM
dti-1373	194	2	−	−	ADP
dti-1373	194	3	−	−	PROPN
dti-1373	195	1	+	+	CCONJ
dti-1373	195	2	+	+	NUM
dti-1373	195	3	−	−	NOUN
dti-1373	195	4	−	−	NOUN
dti-1373	195	5	−	−	PROPN
dti-1373	196	1	+	+	CCONJ
dti-1373	197	1	+	+	CCONJ
dti-1373	197	2	−	−	X
dti-1373	197	3	+	+	CCONJ
dti-1373	197	4	−	−	PROPN
dti-1373	198	1	+	+	CCONJ
dti-1373	198	2	−	−	PROPN
dti-1373	199	1	+	+	CCONJ
dti-1373	200	1	+	+	NUM
dti-1373	200	2	−	−	ADP
dti-1373	200	3	−	−	PROPN
dti-1373	201	1	+	+	CCONJ
dti-1373	202	1	+	+	CCONJ
dti-1373	202	2	a	a	DET
dti-1373	202	3	b	b	NOUN
dti-1373	202	4	sisirt1	sisirt1	NOUN
dti-1373	202	5	pma	pma	NOUN
dti-1373	202	6	resveratrol	resveratrol	NOUN
dti-1373	202	7	pma	pma	NOUN
dti-1373	202	8	resveratrol	resveratrol	NOUN
dti-1373	202	9	cox-2	cox-2	SYM
dti-1373	202	10	prommp-9	prommp-9	NUM
dti-1373	202	11	gapdh	gapdh	NOUN
dti-1373	202	12	mock	mock	ADJ
dti-1373	202	13	sisirt1	sisirt1	NOUN
dti-1373	202	14	figure	figure	NOUN
dti-1373	202	15	6	6	NUM
dti-1373	202	16	.	.	PUNCT
dti-1373	203	1	sirt1	sirt1	ADJ
dti-1373	203	2	-	-	ADJ
dti-1373	203	3	independent	independent	ADJ
dti-1373	203	4	inhibition	inhibition	NOUN
dti-1373	203	5	by	by	ADP
dti-1373	203	6	resveratrol	resveratrol	NOUN
dti-1373	203	7	of	of	ADP
dti-1373	203	8	pma	pma	NOUN
dti-1373	203	9	-	-	PUNCT
dti-1373	203	10	induced	induce	VERB
dti-1373	203	11	cox-2	cox-2	ADJ
dti-1373	203	12	expression	expression	NOUN
dti-1373	203	13	and	and	CCONJ
dti-1373	203	14	of	of	ADP
dti-1373	203	15	pma	pma	NOUN
dti-1373	203	16	-	-	PUNCT
dti-1373	203	17	induced	induce	VERB
dti-1373	203	18	mmp-9	mmp-9	NOUN
dti-1373	203	19	secretion	secretion	NOUN
dti-1373	203	20	.	.	PUNCT
dti-1373	204	1	mock	mock	ADJ
dti-1373	204	2	or	or	CCONJ
dti-1373	204	3	sisirt1	sisirt1	NOUN
dti-1373	204	4	-	-	PUNCT
dti-1373	204	5	transfected	transfecte	VERB
dti-1373	204	6	hbmec	hbmec	NOUN
dti-1373	204	7	were	be	AUX
dti-1373	204	8	serum	serum	NOUN
dti-1373	204	9	-	-	PUNCT
dti-1373	204	10	starved	starve	VERB
dti-1373	204	11	in	in	ADP
dti-1373	204	12	the	the	DET
dti-1373	204	13	presence	presence	NOUN
dti-1373	204	14	of	of	ADP
dti-1373	204	15	1	1	NUM
dti-1373	204	16	µm	µm	ADP
dti-1373	204	17	pma	pma	NOUN
dti-1373	204	18	,	,	PUNCT
dti-1373	204	19	30	30	NUM
dti-1373	204	20	µm	µm	ADP
dti-1373	204	21	resveratrol	resveratrol	NOUN
dti-1373	204	22	,	,	PUNCT
dti-1373	204	23	or	or	CCONJ
dti-1373	204	24	a	a	DET
dti-1373	204	25	combination	combination	NOUN
dti-1373	204	26	of	of	ADP
dti-1373	204	27	both	both	DET
dti-1373	204	28	agents	agent	NOUN
dti-1373	204	29	for	for	ADP
dti-1373	204	30	18	18	NUM
dti-1373	204	31	hours	hour	NOUN
dti-1373	204	32	.	.	PUNCT
dti-1373	205	1	(	(	PUNCT
dti-1373	205	2	a	a	X
dti-1373	205	3	)	)	PUNCT
dti-1373	205	4	lysates	lysate	NOUN
dti-1373	205	5	were	be	AUX
dti-1373	205	6	isolated	isolate	VERB
dti-1373	205	7	,	,	PUNCT
dti-1373	205	8	electrophoresed	electrophorese	VERB
dti-1373	205	9	via	via	ADP
dti-1373	205	10	sds	sds	PROPN
dti-1373	205	11	-	-	PUNCT
dti-1373	205	12	page	page	NOUN
dti-1373	205	13	,	,	PUNCT
dti-1373	205	14	and	and	CCONJ
dti-1373	205	15	immunodetection	immunodetection	NOUN
dti-1373	205	16	of	of	ADP
dti-1373	205	17	cox-2	cox-2	NOUN
dti-1373	205	18	and	and	CCONJ
dti-1373	205	19	gapdh	gapdh	NOUN
dti-1373	205	20	performed	perform	VERB
dti-1373	205	21	as	as	SCONJ
dti-1373	205	22	described	describe	VERB
dti-1373	205	23	in	in	ADP
dti-1373	205	24	the	the	DET
dti-1373	205	25	methods	method	NOUN
dti-1373	205	26	section	section	NOUN
dti-1373	205	27	.	.	PUNCT
dti-1373	206	1	(	(	PUNCT
dti-1373	206	2	b	b	X
dti-1373	206	3	)	)	PUNCT
dti-1373	206	4	conditioned	condition	VERB
dti-1373	206	5	media	medium	NOUN
dti-1373	206	6	were	be	AUX
dti-1373	206	7	also	also	ADV
dti-1373	206	8	harvested	harvest	VERB
dti-1373	206	9	and	and	CCONJ
dti-1373	206	10	gelatin	gelatin	NOUN
dti-1373	206	11	zymography	zymography	PROPN
dti-1373	206	12	was	be	AUX
dti-1373	206	13	performed	perform	VERB
dti-1373	206	14	in	in	ADP
dti-1373	206	15	order	order	NOUN
dti-1373	206	16	to	to	PART
dti-1373	206	17	detect	detect	VERB
dti-1373	206	18	pma	pma	NOUN
dti-1373	206	19	-	-	PUNCT
dti-1373	206	20	induced	induce	VERB
dti-1373	206	21	prommp-9	prommp-9	NOUN
dti-1373	206	22	and	and	CCONJ
dti-1373	206	23	hydrolytic	hydrolytic	ADJ
dti-1373	206	24	activity	activity	NOUN
dti-1373	206	25	as	as	SCONJ
dti-1373	206	26	described	describe	VERB
dti-1373	206	27	in	in	ADP
dti-1373	206	28	the	the	DET
dti-1373	206	29	methods	method	NOUN
dti-1373	206	30	section	section	NOUN
dti-1373	206	31	.	.	PUNCT
dti-1373	207	1	http://www.la-press.com	http://www.la-press.com	X
dti-1373	207	2	annabi	annabi	PROPN
dti-1373	207	3	et	et	PROPN
dti-1373	207	4	al	al	PROPN
dti-1373	207	5	10	10	NUM
dti-1373	207	6	drug	drug	NOUN
dti-1373	207	7	target	target	NOUN
dti-1373	207	8	insights	insight	NOUN
dti-1373	207	9	2012:6	2012:6	NUM
dti-1373	207	10	the	the	DET
dti-1373	207	11	external	external	ADJ
dti-1373	207	12	blind	blind	ADJ
dti-1373	207	13	peer	peer	NOUN
dti-1373	207	14	reviewers	reviewer	NOUN
dti-1373	207	15	report	report	VERB
dti-1373	207	16	no	no	DET
dti-1373	207	17	conflicts	conflict	NOUN
dti-1373	207	18	of	of	ADP
dti-1373	207	19	interest	interest	NOUN
dti-1373	207	20	.	.	PUNCT
dti-1373	208	1	references	reference	NOUN
dti-1373	208	2	1	1	NUM
dti-1373	208	3	.	.	PUNCT
dti-1373	209	1	hanahan	hanahan	PROPN
dti-1373	209	2	d	d	PROPN
dti-1373	209	3	,	,	PUNCT
dti-1373	209	4	folkman	folkman	PROPN
dti-1373	209	5	j.	j.	PROPN
dti-1373	209	6	patterns	patterns	PROPN
dti-1373	209	7	and	and	CCONJ
dti-1373	209	8	emerging	emerge	VERB
dti-1373	209	9	mechanisms	mechanism	NOUN
dti-1373	209	10	of	of	ADP
dti-1373	209	11	the	the	DET
dti-1373	209	12	angiogenic	angiogenic	ADJ
dti-1373	209	13	switch	switch	NOUN
dti-1373	209	14	during	during	ADP
dti-1373	209	15	tumorigenesis	tumorigenesis	NOUN
dti-1373	209	16	.	.	PUNCT
dti-1373	210	1	cell	cell	NOUN
dti-1373	210	2	.	.	PUNCT
dti-1373	211	1	1996;86:353–64	1996;86:353–64	NUM
dti-1373	211	2	.	.	PROPN
dti-1373	212	1	2	2	NUM
dti-1373	212	2	.	.	X
dti-1373	213	1	rojas	rojas	PROPN
dti-1373	213	2	a	a	PROPN
dti-1373	213	3	,	,	PUNCT
dti-1373	213	4	figueroa	figueroa	PROPN
dti-1373	213	5	h	h	PROPN
dti-1373	213	6	,	,	PUNCT
dti-1373	213	7	morales	morales	PROPN
dti-1373	213	8	e.	e.	PROPN
dti-1373	213	9	fueling	fuel	VERB
dti-1373	213	10	inflammation	inflammation	NOUN
dti-1373	213	11	at	at	ADP
dti-1373	213	12	tumor	tumor	NOUN
dti-1373	213	13	microenvironment	microenvironment	NOUN
dti-1373	213	14	:	:	PUNCT
dti-1373	213	15	the	the	DET
dti-1373	213	16	role	role	NOUN
dti-1373	213	17	of	of	ADP
dti-1373	213	18	multiligand	multiligand	NOUN
dti-1373	213	19	/	/	SYM
dti-1373	213	20	rage	rage	NOUN
dti-1373	213	21	axis	axis	NOUN
dti-1373	213	22	.	.	PUNCT
dti-1373	214	1	carcinogenesis	carcinogenesis	NOUN
dti-1373	214	2	.	.	PUNCT
dti-1373	215	1	2010	2010	NUM
dti-1373	215	2	;	;	PUNCT
dti-1373	215	3	31:334–41	31:334–41	X
dti-1373	215	4	.	.	PUNCT
dti-1373	216	1	3	3	X
dti-1373	216	2	.	.	X
dti-1373	216	3	hayes	hayes	PROPN
dti-1373	216	4	a.	a.	NOUN
dti-1373	216	5	cancer	cancer	NOUN
dti-1373	216	6	,	,	PUNCT
dti-1373	216	7	cyclo	cyclo	NOUN
dti-1373	216	8	-	-	PUNCT
dti-1373	216	9	oxygenase	oxygenase	NOUN
dti-1373	216	10	and	and	CCONJ
dti-1373	216	11	nonsteroidal	nonsteroidal	NOUN
dti-1373	216	12	anti	anti	ADJ
dti-1373	216	13	-	-	ADJ
dti-1373	216	14	inflammatory	inflammatory	ADJ
dti-1373	216	15	drugs	drug	NOUN
dti-1373	216	16	—	—	PUNCT
dti-1373	216	17	can	can	AUX
dti-1373	216	18	we	we	PRON
dti-1373	216	19	combine	combine	VERB
dti-1373	216	20	all	all	DET
dti-1373	216	21	three	three	NUM
dti-1373	216	22	?	?	PUNCT
dti-1373	217	1	vet	vet	NOUN
dti-1373	217	2	comp	comp	NOUN
dti-1373	217	3	oncol	oncol	ADJ
dti-1373	217	4	.	.	PUNCT
dti-1373	218	1	2007;5:1–13	2007;5:1–13	NUM
dti-1373	218	2	.	.	NOUN
dti-1373	218	3	4	4	NUM
dti-1373	218	4	.	.	X
dti-1373	218	5	costa	costa	PROPN
dti-1373	218	6	c	c	PROPN
dti-1373	218	7	,	,	PUNCT
dti-1373	218	8	soares	soares	PROPN
dti-1373	218	9	r	r	NOUN
dti-1373	218	10	,	,	PUNCT
dti-1373	218	11	reis	reis	NOUN
dti-1373	218	12	-	-	PUNCT
dti-1373	218	13	filho	filho	NOUN
dti-1373	218	14	js	js	PROPN
dti-1373	218	15	,	,	PUNCT
dti-1373	218	16	leitão	leitão	PROPN
dti-1373	218	17	d	d	PROPN
dti-1373	218	18	,	,	PUNCT
dti-1373	218	19	amendoeira	amendoeira	PROPN
dti-1373	218	20	i	i	PRON
dti-1373	218	21	,	,	PUNCT
dti-1373	218	22	schmitt	schmitt	PROPN
dti-1373	218	23	fc	fc	PROPN
dti-1373	218	24	.	.	PUNCT
dti-1373	218	25	cyclo	cyclo	PROPN
dti-1373	218	26	-	-	PUNCT
dti-1373	218	27	oxygenase	oxygenase	NOUN
dti-1373	218	28	2	2	NUM
dti-1373	218	29	expression	expression	NOUN
dti-1373	218	30	is	be	AUX
dti-1373	218	31	associated	associate	VERB
dti-1373	218	32	with	with	ADP
dti-1373	218	33	angiogenesis	angiogenesis	NOUN
dti-1373	218	34	and	and	CCONJ
dti-1373	218	35	lymph	lymph	NOUN
dti-1373	218	36	node	node	NOUN
dti-1373	218	37	metastasis	metastasis	NOUN
dti-1373	218	38	in	in	ADP
dti-1373	218	39	human	human	ADJ
dti-1373	218	40	breast	breast	NOUN
dti-1373	218	41	cancer	cancer	NOUN
dti-1373	218	42	.	.	PUNCT
dti-1373	219	1	j	j	PROPN
dti-1373	219	2	clin	clin	PROPN
dti-1373	219	3	pathol	pathol	PROPN
dti-1373	219	4	.	.	PUNCT
dti-1373	220	1	2002;55:429–34	2002;55:429–34	X
dti-1373	220	2	.	.	NOUN
dti-1373	221	1	5	5	NUM
dti-1373	221	2	.	.	X
dti-1373	221	3	fournier	fournier	PROPN
dti-1373	221	4	ls	ls	PROPN
dti-1373	221	5	,	,	PUNCT
dti-1373	221	6	novikov	novikov	ADJ
dti-1373	221	7	v	v	NOUN
dti-1373	221	8	,	,	PUNCT
dti-1373	221	9	lucidi	lucidi	PROPN
dti-1373	221	10	v	v	PROPN
dti-1373	221	11	,	,	PUNCT
dti-1373	221	12	et	et	PROPN
dti-1373	221	13	al	al	PROPN
dti-1373	221	14	.	.	PUNCT
dti-1373	222	1	mr	mr	PROPN
dti-1373	222	2	monitoring	monitoring	NOUN
dti-1373	222	3	of	of	ADP
dti-1373	222	4	cyclooxygenase-2	cyclooxygenase-2	NUM
dti-1373	222	5	inhibition	inhibition	NOUN
dti-1373	222	6	of	of	ADP
dti-1373	222	7	angiogenesis	angiogenesis	NOUN
dti-1373	222	8	in	in	ADP
dti-1373	222	9	a	a	DET
dti-1373	222	10	human	human	ADJ
dti-1373	222	11	breast	breast	NOUN
dti-1373	222	12	cancer	cancer	NOUN
dti-1373	222	13	model	model	NOUN
dti-1373	222	14	in	in	ADP
dti-1373	222	15	rats	rat	NOUN
dti-1373	222	16	.	.	PUNCT
dti-1373	223	1	radiology	radiology	NOUN
dti-1373	223	2	.	.	PUNCT
dti-1373	224	1	2007;243:105–11	2007;243:105–11	NUM
dti-1373	224	2	.	.	PROPN
dti-1373	225	1	6	6	NUM
dti-1373	225	2	.	.	X
dti-1373	225	3	müller	müller	PROPN
dti-1373	225	4	-	-	PUNCT
dti-1373	225	5	decker	decker	PROPN
dti-1373	225	6	k	k	PROPN
dti-1373	225	7	,	,	PUNCT
dti-1373	225	8	fürstenberger	fürstenberger	NOUN
dti-1373	225	9	g.	g.	PROPN
dti-1373	225	10	the	the	DET
dti-1373	225	11	cyclooxygenase-2	cyclooxygenase-2	ADV
dti-1373	225	12	-	-	PUNCT
dti-1373	225	13	mediated	mediate	VERB
dti-1373	225	14	prostaglandin	prostaglandin	NOUN
dti-1373	225	15	signaling	signal	VERB
dti-1373	225	16	is	be	AUX
dti-1373	225	17	causally	causally	ADV
dti-1373	225	18	related	relate	VERB
dti-1373	225	19	to	to	ADP
dti-1373	225	20	epithelial	epithelial	ADJ
dti-1373	225	21	carcinogenesis	carcinogenesis	NOUN
dti-1373	225	22	.	.	PUNCT
dti-1373	226	1	mol	mol	ADP
dti-1373	226	2	carcinog	carcinog	PROPN
dti-1373	226	3	.	.	PUNCT
dti-1373	227	1	2007;46:705–10	2007;46:705–10	X
dti-1373	227	2	.	.	PROPN
dti-1373	228	1	7	7	X
dti-1373	228	2	.	.	NUM
dti-1373	228	3	neergheen	neergheen	VERB
dti-1373	228	4	vs	vs	ADP
dti-1373	228	5	,	,	PUNCT
dti-1373	228	6	bahorun	bahorun	PROPN
dti-1373	228	7	t	t	PROPN
dti-1373	228	8	,	,	PUNCT
dti-1373	228	9	taylor	taylor	PROPN
dti-1373	228	10	ew	ew	PROPN
dti-1373	228	11	,	,	PUNCT
dti-1373	228	12	jen	jen	PROPN
dti-1373	228	13	ls	ls	PROPN
dti-1373	228	14	,	,	PUNCT
dti-1373	228	15	aruoma	aruoma	PROPN
dti-1373	228	16	oi	oi	VERB
dti-1373	228	17	.	.	PUNCT
dti-1373	229	1	targeting	target	VERB
dti-1373	229	2	specific	specific	ADJ
dti-1373	229	3	cell	cell	NOUN
dti-1373	229	4	signaling	signal	VERB
dti-1373	229	5	transduction	transduction	NOUN
dti-1373	229	6	pathways	pathway	NOUN
dti-1373	229	7	by	by	ADP
dti-1373	229	8	dietary	dietary	ADJ
dti-1373	229	9	and	and	CCONJ
dti-1373	229	10	medicinal	medicinal	ADJ
dti-1373	229	11	phytochemicals	phytochemical	NOUN
dti-1373	229	12	in	in	ADP
dti-1373	229	13	cancer	cancer	NOUN
dti-1373	229	14	chemoprevention	chemoprevention	NOUN
dti-1373	229	15	.	.	PUNCT
dti-1373	230	1	toxicology	toxicology	NOUN
dti-1373	230	2	.	.	PUNCT
dti-1373	231	1	2010;278:229–41	2010;278:229–41	NUM
dti-1373	231	2	.	.	NOUN
dti-1373	231	3	8	8	NUM
dti-1373	231	4	.	.	PUNCT
dti-1373	231	5	lakka	lakka	PROPN
dti-1373	231	6	ss	ss	PROPN
dti-1373	231	7	,	,	PUNCT
dti-1373	231	8	gondi	gondi	NOUN
dti-1373	231	9	cs	cs	PROPN
dti-1373	231	10	,	,	PUNCT
dti-1373	231	11	rao	rao	PROPN
dti-1373	231	12	js	js	PROPN
dti-1373	231	13	.	.	PUNCT
dti-1373	232	1	proteases	protease	NOUN
dti-1373	232	2	and	and	CCONJ
dti-1373	232	3	glioma	glioma	ADJ
dti-1373	232	4	angiogenesis	angiogenesis	NOUN
dti-1373	232	5	.	.	PUNCT
dti-1373	233	1	brain	brain	NOUN
dti-1373	233	2	pathol	pathol	NOUN
dti-1373	233	3	.	.	PUNCT
dti-1373	234	1	2005;15:327–41	2005;15:327–41	X
dti-1373	234	2	.	.	NOUN
dti-1373	235	1	9	9	NUM
dti-1373	235	2	.	.	X
dti-1373	235	3	bonoiu	bonoiu	PROPN
dti-1373	235	4	a	a	PRON
dti-1373	235	5	,	,	PUNCT
dti-1373	235	6	mahajan	mahajan	PROPN
dti-1373	235	7	sd	sd	PROPN
dti-1373	235	8	,	,	PUNCT
dti-1373	235	9	ye	ye	PROPN
dti-1373	235	10	l	l	NOUN
dti-1373	235	11	,	,	PUNCT
dti-1373	235	12	et	et	PROPN
dti-1373	235	13	al	al	PROPN
dti-1373	235	14	.	.	PROPN
dti-1373	236	1	mmp-9	mmp-9	VERB
dti-1373	236	2	gene	gene	NOUN
dti-1373	236	3	silencing	silence	VERB
dti-1373	236	4	by	by	ADP
dti-1373	236	5	a	a	DET
dti-1373	236	6	quantum	quantum	NOUN
dti-1373	236	7	dot	dot	NOUN
dti-1373	236	8	-	-	PUNCT
dti-1373	236	9	sirna	sirna	PROPN
dti-1373	236	10	nanoplex	nanoplex	PROPN
dti-1373	236	11	delivery	delivery	NOUN
dti-1373	236	12	to	to	PART
dti-1373	236	13	maintain	maintain	VERB
dti-1373	236	14	the	the	DET
dti-1373	236	15	integrity	integrity	NOUN
dti-1373	236	16	of	of	ADP
dti-1373	236	17	the	the	DET
dti-1373	236	18	blood	blood	NOUN
dti-1373	236	19	brain	brain	NOUN
dti-1373	236	20	barrier	barrier	NOUN
dti-1373	236	21	.	.	PUNCT
dti-1373	237	1	brain	brain	NOUN
dti-1373	237	2	res	re	NOUN
dti-1373	237	3	.	.	PUNCT
dti-1373	237	4	2009;1282:142–55	2009;1282:142–55	NUM
dti-1373	237	5	.	.	PUNCT
dti-1373	238	1	10	10	NUM
dti-1373	238	2	.	.	PUNCT
dti-1373	238	3	annabi	annabi	PROPN
dti-1373	238	4	b	b	PROPN
dti-1373	238	5	,	,	PUNCT
dti-1373	238	6	rojas	rojas	PROPN
dti-1373	238	7	-	-	PUNCT
dti-1373	238	8	sutterlin	sutterlin	PROPN
dti-1373	238	9	s	s	PROPN
dti-1373	238	10	,	,	PUNCT
dti-1373	238	11	laroche	laroche	PROPN
dti-1373	238	12	m	m	PROPN
dti-1373	238	13	,	,	PUNCT
dti-1373	238	14	lachambre	lachambre	PROPN
dti-1373	238	15	mp	mp	PROPN
dti-1373	238	16	,	,	PUNCT
dti-1373	238	17	moumdjian	moumdjian	ADJ
dti-1373	238	18	r	r	PROPN
dti-1373	238	19	,	,	PUNCT
dti-1373	238	20	béliveau	béliveau	PROPN
dti-1373	238	21	r.	r.	PROPN
dti-1373	238	22	the	the	DET
dti-1373	238	23	diet	diet	NOUN
dti-1373	238	24	-	-	PUNCT
dti-1373	238	25	derived	derive	VERB
dti-1373	238	26	sulforaphane	sulforaphane	NOUN
dti-1373	238	27	inhibits	inhibit	VERB
dti-1373	238	28	matrix	matrix	NOUN
dti-1373	238	29	metalloproteinase9	metalloproteinase9	NOUN
dti-1373	238	30	-	-	PUNCT
dti-1373	238	31	activated	activate	VERB
dti-1373	238	32	human	human	ADJ
dti-1373	238	33	brain	brain	NOUN
dti-1373	238	34	microvascular	microvascular	NOUN
dti-1373	238	35	endothelial	endothelial	ADJ
dti-1373	238	36	cell	cell	NOUN
dti-1373	238	37	migration	migration	NOUN
dti-1373	238	38	and	and	CCONJ
dti-1373	238	39	tubulogenesis	tubulogenesis	NOUN
dti-1373	238	40	.	.	PUNCT
dti-1373	239	1	mol	mol	ADP
dti-1373	239	2	nutr	nutr	NOUN
dti-1373	239	3	food	food	NOUN
dti-1373	239	4	res	re	NOUN
dti-1373	239	5	.	.	PUNCT
dti-1373	240	1	2008;52:692–700	2008;52:692–700	NOUN
dti-1373	240	2	.	.	PUNCT
dti-1373	241	1	11	11	NUM
dti-1373	241	2	.	.	X
dti-1373	242	1	roomi	roomi	PROPN
dti-1373	242	2	mw	mw	PROPN
dti-1373	242	3	,	,	PUNCT
dti-1373	242	4	monterrey	monterrey	PROPN
dti-1373	242	5	jc	jc	PROPN
dti-1373	242	6	,	,	PUNCT
dti-1373	242	7	kalinovsky	kalinovsky	PROPN
dti-1373	242	8	t	t	PROPN
dti-1373	242	9	,	,	PUNCT
dti-1373	242	10	rath	rath	PROPN
dti-1373	242	11	m	m	PROPN
dti-1373	242	12	,	,	PUNCT
dti-1373	242	13	niedzwiecki	niedzwiecki	PROPN
dti-1373	242	14	a.	a.	PROPN
dti-1373	242	15	distinct	distinct	PROPN
dti-1373	242	16	patterns	pattern	NOUN
dti-1373	242	17	of	of	ADP
dti-1373	242	18	matrix	matrix	NOUN
dti-1373	242	19	metalloproteinase-2	metalloproteinase-2	NUM
dti-1373	242	20	and	and	CCONJ
dti-1373	242	21	-9	-9	ADV
dti-1373	242	22	expression	expression	NOUN
dti-1373	242	23	in	in	ADP
dti-1373	242	24	normal	normal	ADJ
dti-1373	242	25	human	human	ADJ
dti-1373	242	26	cell	cell	NOUN
dti-1373	242	27	lines	line	NOUN
dti-1373	242	28	.	.	PUNCT
dti-1373	243	1	oncol	oncol	PROPN
dti-1373	243	2	rep	rep	PROPN
dti-1373	243	3	.	.	PROPN
dti-1373	243	4	2009;21:821–6	2009;21:821–6	NUM
dti-1373	243	5	.	.	PUNCT
dti-1373	244	1	12	12	NUM
dti-1373	244	2	.	.	PUNCT
dti-1373	245	1	jadhav	jadhav	PROPN
dti-1373	245	2	u	u	PROPN
dti-1373	245	3	,	,	PUNCT
dti-1373	245	4	chigurupati	chigurupati	PROPN
dti-1373	245	5	s	s	PROPN
dti-1373	245	6	,	,	PUNCT
dti-1373	245	7	lakka	lakka	PROPN
dti-1373	245	8	ss	ss	PROPN
dti-1373	245	9	,	,	PUNCT
dti-1373	245	10	mohanam	mohanam	PROPN
dti-1373	245	11	s.	s.	PROPN
dti-1373	245	12	inhibition	inhibition	NOUN
dti-1373	245	13	of	of	ADP
dti-1373	245	14	matrix	matrix	NOUN
dti-1373	245	15	metalloproteinase-9	metalloproteinase-9	NUM
dti-1373	245	16	reduces	reduce	VERB
dti-1373	245	17	in	in	ADP
dti-1373	245	18	vitro	vitro	X
dti-1373	245	19	invasion	invasion	NOUN
dti-1373	245	20	and	and	CCONJ
dti-1373	245	21	angiogenesis	angiogenesis	NOUN
dti-1373	245	22	in	in	ADP
dti-1373	245	23	human	human	ADJ
dti-1373	245	24	microvascular	microvascular	NOUN
dti-1373	245	25	endothelial	endothelial	ADJ
dti-1373	245	26	cells	cell	NOUN
dti-1373	245	27	.	.	PUNCT
dti-1373	246	1	int	int	NOUN
dti-1373	246	2	j	j	PROPN
dti-1373	246	3	oncol	oncol	ADJ
dti-1373	246	4	.	.	PUNCT
dti-1373	247	1	2004;25:1407–14	2004;25:1407–14	NUM
dti-1373	247	2	.	.	NOUN
dti-1373	247	3	13	13	NUM
dti-1373	247	4	.	.	PUNCT
dti-1373	248	1	luqman	luqman	PROPN
dti-1373	248	2	s	s	PROPN
dti-1373	248	3	,	,	PUNCT
dti-1373	248	4	pezzuto	pezzuto	PROPN
dti-1373	248	5	jm	jm	PROPN
dti-1373	248	6	.	.	PROPN
dti-1373	248	7	nfkappab	nfkappab	PROPN
dti-1373	248	8	:	:	PUNCT
dti-1373	248	9	a	a	DET
dti-1373	248	10	promising	promising	ADJ
dti-1373	248	11	target	target	NOUN
dti-1373	248	12	for	for	ADP
dti-1373	248	13	natural	natural	ADJ
dti-1373	248	14	products	product	NOUN
dti-1373	248	15	in	in	ADP
dti-1373	248	16	cancer	cancer	NOUN
dti-1373	248	17	chemoprevention	chemoprevention	PROPN
dti-1373	248	18	.	.	PUNCT
dti-1373	249	1	phytother	phytother	PROPN
dti-1373	249	2	res	re	NOUN
dti-1373	249	3	.	.	PUNCT
dti-1373	250	1	2010;24:949–63	2010;24:949–63	NUM
dti-1373	250	2	.	.	NOUN
dti-1373	250	3	14	14	NUM
dti-1373	250	4	.	.	PUNCT
dti-1373	251	1	tergaonkar	tergaonkar	NOUN
dti-1373	251	2	v.	v.	ADP
dti-1373	251	3	nfkappab	nfkappab	NOUN
dti-1373	251	4	pathway	pathway	NOUN
dti-1373	251	5	:	:	PUNCT
dti-1373	251	6	a	a	DET
dti-1373	251	7	good	good	ADJ
dti-1373	251	8	signaling	signaling	ADJ
dti-1373	251	9	paradigm	paradigm	NOUN
dti-1373	251	10	and	and	CCONJ
dti-1373	251	11	therapeutic	therapeutic	ADJ
dti-1373	251	12	target	target	NOUN
dti-1373	251	13	.	.	PUNCT
dti-1373	252	1	int	int	PROPN
dti-1373	252	2	j	j	PROPN
dti-1373	252	3	biochem	biochem	PROPN
dti-1373	252	4	cell	cell	NOUN
dti-1373	252	5	biol	biol	PROPN
dti-1373	252	6	.	.	PUNCT
dti-1373	253	1	2006;38:1647–53	2006;38:1647–53	NUM
dti-1373	253	2	.	.	X
dti-1373	253	3	15	15	NUM
dti-1373	253	4	.	.	PUNCT
dti-1373	253	5	potente	potente	PROPN
dti-1373	253	6	m	m	PROPN
dti-1373	253	7	,	,	PUNCT
dti-1373	253	8	dimmeler	dimmeler	PROPN
dti-1373	253	9	s.	s.	PROPN
dti-1373	253	10	emerging	emerge	VERB
dti-1373	253	11	roles	role	NOUN
dti-1373	253	12	of	of	ADP
dti-1373	253	13	sirt1	sirt1	NOUN
dti-1373	253	14	in	in	ADP
dti-1373	253	15	vascular	vascular	ADJ
dti-1373	253	16	endothelial	endothelial	NOUN
dti-1373	253	17	homeostasis	homeostasis	NOUN
dti-1373	253	18	.	.	PUNCT
dti-1373	254	1	cell	cell	NOUN
dti-1373	254	2	cycle	cycle	NOUN
dti-1373	254	3	.	.	PUNCT
dti-1373	255	1	2008;7:2117–22	2008;7:2117–22	X
dti-1373	255	2	.	.	NOUN
dti-1373	255	3	16	16	NUM
dti-1373	255	4	.	.	PUNCT
dti-1373	256	1	schlicker	schlicker	AUX
dti-1373	256	2	c	c	PROPN
dti-1373	256	3	,	,	PUNCT
dti-1373	256	4	boanca	boanca	NOUN
dti-1373	256	5	g	g	PROPN
dti-1373	256	6	,	,	PUNCT
dti-1373	256	7	lakshminarasimhan	lakshminarasimhan	PROPN
dti-1373	256	8	m	m	PROPN
dti-1373	256	9	,	,	PUNCT
dti-1373	256	10	steegborn	steegborn	PROPN
dti-1373	256	11	c.	c.	PROPN
dti-1373	256	12	structurebased	structurebase	VERB
dti-1373	256	13	development	development	NOUN
dti-1373	256	14	of	of	ADP
dti-1373	256	15	novel	novel	ADJ
dti-1373	256	16	sirtuin	sirtuin	NOUN
dti-1373	256	17	inhibitors	inhibitor	NOUN
dti-1373	256	18	.	.	PUNCT
dti-1373	257	1	aging	age	VERB
dti-1373	257	2	(	(	PUNCT
dti-1373	257	3	albany	albany	PROPN
dti-1373	257	4	ny	ny	PROPN
dti-1373	257	5	)	)	PUNCT
dti-1373	257	6	.	.	PUNCT
dti-1373	258	1	2011;3	2011;3	NUM
dti-1373	258	2	:	:	PUNCT
dti-1373	258	3	852–72	852–72	NUM
dti-1373	258	4	.	.	PUNCT
dti-1373	259	1	17	17	NUM
dti-1373	259	2	.	.	PUNCT
dti-1373	260	1	liu	liu	PROPN
dti-1373	260	2	g	g	PROPN
dti-1373	260	3	,	,	PUNCT
dti-1373	260	4	yuan	yuan	NOUN
dti-1373	260	5	x	x	X
dti-1373	260	6	,	,	PUNCT
dti-1373	260	7	zeng	zeng	PROPN
dti-1373	260	8	z	z	PROPN
dti-1373	260	9	,	,	PUNCT
dti-1373	260	10	et	et	PROPN
dti-1373	260	11	al	al	PROPN
dti-1373	260	12	.	.	PUNCT
dti-1373	260	13	analysis	analysis	NOUN
dti-1373	260	14	of	of	ADP
dti-1373	260	15	gene	gene	NOUN
dti-1373	260	16	expression	expression	NOUN
dti-1373	260	17	and	and	CCONJ
dti-1373	260	18	chemoresistance	chemoresistance	NOUN
dti-1373	260	19	of	of	ADP
dti-1373	260	20	cd133	cd133	PROPN
dti-1373	260	21	+	+	NOUN
dti-1373	260	22	cancer	cancer	NOUN
dti-1373	260	23	stem	stem	NOUN
dti-1373	260	24	cells	cell	NOUN
dti-1373	260	25	in	in	ADP
dti-1373	260	26	glioblastoma	glioblastoma	NOUN
dti-1373	260	27	.	.	PUNCT
dti-1373	261	1	mol	mol	ADP
dti-1373	261	2	cancer	cancer	NOUN
dti-1373	261	3	.	.	PUNCT
dti-1373	262	1	2006;5:67	2006;5:67	PROPN
dti-1373	262	2	.	.	PUNCT
dti-1373	263	1	18	18	NUM
dti-1373	263	2	.	.	X
dti-1373	263	3	chang	chang	PROPN
dti-1373	263	4	cj	cj	PROPN
dti-1373	263	5	,	,	PUNCT
dti-1373	263	6	hsu	hsu	PROPN
dti-1373	263	7	cc	cc	PROPN
dti-1373	263	8	,	,	PUNCT
dti-1373	263	9	yung	yung	PROPN
dti-1373	263	10	mc	mc	PROPN
dti-1373	263	11	,	,	PUNCT
dti-1373	263	12	et	et	PROPN
dti-1373	263	13	al	al	PROPN
dti-1373	263	14	.	.	PROPN
dti-1373	263	15	enhanced	enhance	VERB
dti-1373	263	16	radiosensitivity	radiosensitivity	NOUN
dti-1373	263	17	and	and	CCONJ
dti-1373	263	18	radiation	radiation	NOUN
dti-1373	263	19	-	-	PUNCT
dti-1373	263	20	induced	induce	VERB
dti-1373	263	21	apoptosis	apoptosis	NOUN
dti-1373	263	22	in	in	ADP
dti-1373	263	23	glioma	glioma	NOUN
dti-1373	263	24	cd133	cd133	ADJ
dti-1373	263	25	-	-	ADJ
dti-1373	263	26	positive	positive	ADJ
dti-1373	263	27	cells	cell	NOUN
dti-1373	263	28	by	by	ADP
dti-1373	263	29	knockdown	knockdown	NOUN
dti-1373	263	30	of	of	ADP
dti-1373	263	31	sirt1	sirt1	NOUN
dti-1373	263	32	expression	expression	NOUN
dti-1373	263	33	.	.	PUNCT
dti-1373	264	1	biochem	biochem	PROPN
dti-1373	264	2	biophys	biophy	VERB
dti-1373	264	3	res	re	NOUN
dti-1373	264	4	commun	commun	PROPN
dti-1373	264	5	.	.	PUNCT
dti-1373	265	1	2009;380:236–42	2009;380:236–42	NUM
dti-1373	265	2	.	.	PROPN
dti-1373	266	1	19	19	NUM
dti-1373	266	2	.	.	PUNCT
dti-1373	266	3	wang	wang	PROPN
dti-1373	266	4	rh	rh	PROPN
dti-1373	266	5	,	,	PUNCT
dti-1373	266	6	sengupta	sengupta	PROPN
dti-1373	266	7	k	k	PROPN
dti-1373	266	8	,	,	PUNCT
dti-1373	266	9	li	li	PROPN
dti-1373	266	10	c	c	PROPN
dti-1373	266	11	,	,	PUNCT
dti-1373	266	12	et	et	PROPN
dti-1373	266	13	al	al	PROPN
dti-1373	266	14	.	.	PROPN
dti-1373	266	15	impaired	impair	VERB
dti-1373	266	16	dna	dna	PROPN
dti-1373	266	17	damage	damage	NOUN
dti-1373	266	18	response	response	NOUN
dti-1373	266	19	,	,	PUNCT
dti-1373	266	20	genome	genome	NOUN
dti-1373	266	21	instability	instability	NOUN
dti-1373	266	22	,	,	PUNCT
dti-1373	266	23	and	and	CCONJ
dti-1373	266	24	tumorigenesis	tumorigenesis	NOUN
dti-1373	266	25	in	in	ADP
dti-1373	266	26	sirt1	sirt1	NOUN
dti-1373	266	27	mutant	mutant	ADJ
dti-1373	266	28	mice	mouse	NOUN
dti-1373	266	29	.	.	PUNCT
dti-1373	267	1	cancer	cancer	NOUN
dti-1373	267	2	cell	cell	NOUN
dti-1373	267	3	.	.	PUNCT
dti-1373	268	1	2008;14:312–23	2008;14:312–23	X
dti-1373	268	2	.	.	NOUN
dti-1373	268	3	20	20	NUM
dti-1373	268	4	.	.	PUNCT
dti-1373	269	1	centeno	centeno	PROPN
dti-1373	269	2	-	-	PUNCT
dti-1373	269	3	baez	baez	PROPN
dti-1373	269	4	c	c	PROPN
dti-1373	269	5	,	,	PUNCT
dti-1373	269	6	dallaire	dallaire	NOUN
dti-1373	269	7	p	p	NOUN
dti-1373	269	8	,	,	PUNCT
dti-1373	269	9	marette	marette	NOUN
dti-1373	269	10	a.	a.	NOUN
dti-1373	269	11	resveratrol	resveratrol	NOUN
dti-1373	269	12	inhibition	inhibition	NOUN
dti-1373	269	13	of	of	ADP
dti-1373	269	14	inducible	inducible	ADJ
dti-1373	269	15	nitric	nitric	ADJ
dti-1373	269	16	oxide	oxide	NOUN
dti-1373	269	17	synthase	synthase	NOUN
dti-1373	269	18	in	in	ADP
dti-1373	269	19	skeletal	skeletal	ADJ
dti-1373	269	20	muscle	muscle	NOUN
dti-1373	269	21	involves	involve	VERB
dti-1373	269	22	ampk	ampk	NOUN
dti-1373	269	23	but	but	CCONJ
dti-1373	269	24	not	not	PART
dti-1373	269	25	sirt1	sirt1	PROPN
dti-1373	269	26	.	.	PUNCT
dti-1373	269	27	am	be	AUX
dti-1373	269	28	j	j	PROPN
dti-1373	269	29	physiol	physiol	PROPN
dti-1373	269	30	endocrinol	endocrinol	NOUN
dti-1373	269	31	metab	metab	NOUN
dti-1373	269	32	.	.	PUNCT
dti-1373	270	1	2011;301	2011;301	NUM
dti-1373	270	2	:	:	PUNCT
dti-1373	271	1	e922–30	e922–30	ADJ
dti-1373	271	2	.	.	PROPN
dti-1373	271	3	21	21	NUM
dti-1373	271	4	.	.	PUNCT
dti-1373	272	1	tahanian	tahanian	PROPN
dti-1373	272	2	e	e	NOUN
dti-1373	272	3	,	,	PUNCT
dti-1373	272	4	peiro	peiro	PROPN
dti-1373	272	5	s	s	PROPN
dti-1373	272	6	,	,	PUNCT
dti-1373	272	7	annabi	annabi	PROPN
dti-1373	272	8	b.	b.	PROPN
dti-1373	272	9	low	low	PROPN
dti-1373	272	10	intracellular	intracellular	PROPN
dti-1373	272	11	atp	atp	NOUN
dti-1373	272	12	levels	level	NOUN
dti-1373	272	13	exacerbate	exacerbate	VERB
dti-1373	272	14	carcinogen	carcinogen	NOUN
dti-1373	272	15	-	-	PUNCT
dti-1373	272	16	induced	induce	VERB
dti-1373	272	17	inflammatory	inflammatory	ADJ
dti-1373	272	18	stress	stress	NOUN
dti-1373	272	19	response	response	NOUN
dti-1373	272	20	and	and	CCONJ
dti-1373	272	21	inhibit	inhibit	VERB
dti-1373	272	22	in	in	ADP
dti-1373	272	23	vitro	vitro	X
dti-1373	272	24	tubulogenesis	tubulogenesis	NOUN
dti-1373	272	25	in	in	ADP
dti-1373	272	26	human	human	ADJ
dti-1373	272	27	brain	brain	NOUN
dti-1373	272	28	endothelial	endothelial	ADJ
dti-1373	272	29	cells	cell	NOUN
dti-1373	272	30	.	.	PUNCT
dti-1373	273	1	j	j	PROPN
dti-1373	273	2	inflamm	inflamm	PROPN
dti-1373	273	3	res	res	PROPN
dti-1373	273	4	.	.	PUNCT
dti-1373	274	1	2011;4:1–10	2011;4:1–10	NUM
dti-1373	274	2	.	.	NOUN
dti-1373	275	1	22	22	NUM
dti-1373	275	2	.	.	PUNCT
dti-1373	276	1	greiffenberg	greiffenberg	PROPN
dti-1373	276	2	l	l	PROPN
dti-1373	276	3	,	,	PUNCT
dti-1373	276	4	goebel	goebel	PROPN
dti-1373	276	5	w	w	PROPN
dti-1373	276	6	,	,	PUNCT
dti-1373	276	7	kim	kim	PROPN
dti-1373	276	8	ks	ks	PROPN
dti-1373	276	9	,	,	PUNCT
dti-1373	276	10	et	et	PROPN
dti-1373	276	11	al	al	PROPN
dti-1373	276	12	.	.	PUNCT
dti-1373	276	13	interaction	interaction	NOUN
dti-1373	276	14	of	of	ADP
dti-1373	276	15	listeria	listeria	NOUN
dti-1373	276	16	monocytogenes	monocytogene	NOUN
dti-1373	276	17	with	with	ADP
dti-1373	276	18	human	human	ADJ
dti-1373	276	19	brain	brain	NOUN
dti-1373	276	20	microvascular	microvascular	NOUN
dti-1373	276	21	endothelial	endothelial	ADJ
dti-1373	276	22	cells	cell	NOUN
dti-1373	276	23	:	:	PUNCT
dti-1373	276	24	inlb	inlb	ADJ
dti-1373	276	25	-	-	PUNCT
dti-1373	276	26	dependent	dependent	ADJ
dti-1373	276	27	invasion	invasion	NOUN
dti-1373	276	28	,	,	PUNCT
dti-1373	276	29	long	long	ADJ
dti-1373	276	30	-	-	PUNCT
dti-1373	276	31	term	term	NOUN
dti-1373	276	32	intracellular	intracellular	ADJ
dti-1373	276	33	growth	growth	NOUN
dti-1373	276	34	,	,	PUNCT
dti-1373	276	35	and	and	CCONJ
dti-1373	276	36	spread	spread	VERB
dti-1373	276	37	from	from	ADP
dti-1373	276	38	macrophages	macrophage	NOUN
dti-1373	276	39	to	to	ADP
dti-1373	276	40	endothelial	endothelial	ADJ
dti-1373	276	41	cells	cell	NOUN
dti-1373	276	42	.	.	PUNCT
dti-1373	277	1	infect	infect	VERB
dti-1373	277	2	immun	immun	PROPN
dti-1373	277	3	.	.	PUNCT
dti-1373	278	1	1998;66:5260–7	1998;66:5260–7	PROPN
dti-1373	278	2	.	.	PUNCT
dti-1373	279	1	23	23	NUM
dti-1373	279	2	.	.	PUNCT
dti-1373	280	1	sina	sina	PROPN
dti-1373	280	2	a	a	DET
dti-1373	280	3	,	,	PUNCT
dti-1373	280	4	lord	lord	PROPN
dti-1373	280	5	-	-	PUNCT
dti-1373	280	6	dufour	dufour	PROPN
dti-1373	280	7	s	s	PROPN
dti-1373	280	8	,	,	PUNCT
dti-1373	280	9	annabi	annabi	PROPN
dti-1373	280	10	b.	b.	PROPN
dti-1373	280	11	cell	cell	PROPN
dti-1373	280	12	-	-	PUNCT
dti-1373	280	13	based	base	VERB
dti-1373	280	14	evidence	evidence	NOUN
dti-1373	280	15	for	for	ADP
dti-1373	280	16	aminopeptidase	aminopeptidase	NOUN
dti-1373	280	17	n	n	CCONJ
dti-1373	280	18	/	/	SYM
dti-1373	280	19	cd13	cd13	PROPN
dti-1373	280	20	inhibitor	inhibitor	NOUN
dti-1373	280	21	actinonin	actinonin	ADJ
dti-1373	280	22	targeting	targeting	NOUN
dti-1373	280	23	of	of	ADP
dti-1373	280	24	mt1	mt1	PROPN
dti-1373	280	25	-	-	PUNCT
dti-1373	280	26	mmp	mmp	PROPN
dti-1373	280	27	-	-	PUNCT
dti-1373	280	28	mediated	mediate	VERB
dti-1373	280	29	prommp-2	prommp-2	ADJ
dti-1373	280	30	activation	activation	NOUN
dti-1373	280	31	.	.	PUNCT
dti-1373	281	1	cancer	cancer	NOUN
dti-1373	281	2	lett	lett	PROPN
dti-1373	281	3	.	.	PUNCT
dti-1373	282	1	2009;279:171–6	2009;279:171–6	X
dti-1373	282	2	.	.	PUNCT
dti-1373	283	1	24	24	NUM
dti-1373	283	2	.	.	NUM
dti-1373	283	3	abécassis	abécassis	PROPN
dti-1373	284	1	i	i	PROPN
dti-1373	284	2	,	,	PUNCT
dti-1373	284	3	olofsson	olofsson	PROPN
dti-1373	284	4	b	b	PROPN
dti-1373	284	5	,	,	PUNCT
dti-1373	284	6	schmid	schmid	PROPN
dti-1373	284	7	m	m	PROPN
dti-1373	284	8	,	,	PUNCT
dti-1373	284	9	zalcman	zalcman	PROPN
dti-1373	284	10	g	g	PROPN
dti-1373	284	11	,	,	PUNCT
dti-1373	284	12	karniguian	karniguian	ADJ
dti-1373	284	13	a.	a.	NOUN
dti-1373	284	14	rhoa	rhoa	PROPN
dti-1373	284	15	induces	induce	VERB
dti-1373	284	16	mmp-9	mmp-9	NOUN
dti-1373	284	17	expression	expression	NOUN
dti-1373	284	18	at	at	ADP
dti-1373	284	19	cd44	cd44	PROPN
dti-1373	284	20	lamellipodial	lamellipodial	ADJ
dti-1373	284	21	focal	focal	ADJ
dti-1373	284	22	complexes	complex	NOUN
dti-1373	284	23	and	and	CCONJ
dti-1373	284	24	promotes	promote	VERB
dti-1373	284	25	hmec-1	hmec-1	NUM
dti-1373	284	26	cell	cell	NOUN
dti-1373	284	27	invasion	invasion	NOUN
dti-1373	284	28	.	.	PUNCT
dti-1373	285	1	exp	exp	NOUN
dti-1373	285	2	cell	cell	NOUN
dti-1373	285	3	res	re	NOUN
dti-1373	285	4	.	.	PUNCT
dti-1373	286	1	2003;291:363–76	2003;291:363–76	NUM
dti-1373	286	2	.	.	X
dti-1373	287	1	25	25	NUM
dti-1373	287	2	.	.	PUNCT
dti-1373	288	1	annabi	annabi	PROPN
dti-1373	288	2	b	b	PROPN
dti-1373	288	3	,	,	PUNCT
dti-1373	288	4	currie	currie	PROPN
dti-1373	288	5	jc	jc	PROPN
dti-1373	288	6	,	,	PUNCT
dti-1373	288	7	moghrabi	moghrabi	PROPN
dti-1373	288	8	a	a	PRON
dti-1373	288	9	,	,	PUNCT
dti-1373	288	10	béliveau	béliveau	PROPN
dti-1373	288	11	r.	r.	PROPN
dti-1373	288	12	inhibition	inhibition	NOUN
dti-1373	288	13	of	of	ADP
dti-1373	288	14	hur	hur	NOUN
dti-1373	288	15	and	and	CCONJ
dti-1373	288	16	mmp-9	mmp-9	NOUN
dti-1373	288	17	expression	expression	NOUN
dti-1373	288	18	in	in	ADP
dti-1373	288	19	macrophage	macrophage	ADV
dti-1373	288	20	-	-	PUNCT
dti-1373	288	21	differentiated	differentiate	VERB
dti-1373	288	22	hl-60	hl-60	PUNCT
dti-1373	288	23	myeloid	myeloid	NOUN
dti-1373	288	24	leukemia	leukemia	NOUN
dti-1373	288	25	cells	cell	NOUN
dti-1373	288	26	by	by	ADP
dti-1373	288	27	green	green	ADJ
dti-1373	288	28	tea	tea	NOUN
dti-1373	288	29	polyphenol	polyphenol	NOUN
dti-1373	288	30	egcg	egcg	NOUN
dti-1373	288	31	.	.	PUNCT
dti-1373	289	1	leuk	leuk	PROPN
dti-1373	289	2	res	re	NOUN
dti-1373	289	3	.	.	PUNCT
dti-1373	290	1	2007;31:1277–84	2007;31:1277–84	NOUN
dti-1373	290	2	.	.	PUNCT
dti-1373	291	1	26	26	NUM
dti-1373	291	2	.	.	PUNCT
dti-1373	292	1	tahanian	tahanian	PROPN
dti-1373	292	2	e	e	NOUN
dti-1373	292	3	,	,	PUNCT
dti-1373	292	4	lord	lord	PROPN
dti-1373	292	5	-	-	PUNCT
dti-1373	292	6	dufour	dufour	PROPN
dti-1373	292	7	s	s	PROPN
dti-1373	292	8	,	,	PUNCT
dti-1373	292	9	das	das	PROPN
dti-1373	292	10	a	a	PRON
dti-1373	292	11	,	,	PUNCT
dti-1373	292	12	khosla	khosla	PROPN
dti-1373	292	13	c	c	PROPN
dti-1373	292	14	,	,	PUNCT
dti-1373	292	15	roy	roy	PROPN
dti-1373	292	16	r	r	PROPN
dti-1373	292	17	,	,	PUNCT
dti-1373	292	18	annabi	annabi	PROPN
dti-1373	292	19	b.	b.	PROPN
dti-1373	292	20	inhibition	inhibition	NOUN
dti-1373	292	21	of	of	ADP
dti-1373	292	22	tubulogenesis	tubulogenesis	NOUN
dti-1373	292	23	and	and	CCONJ
dti-1373	292	24	of	of	ADP
dti-1373	292	25	carcinogen	carcinogen	NOUN
dti-1373	292	26	-	-	PUNCT
dti-1373	292	27	mediated	mediate	VERB
dti-1373	292	28	signaling	signal	VERB
dti-1373	292	29	in	in	ADP
dti-1373	292	30	brain	brain	NOUN
dti-1373	292	31	endothelial	endothelial	NOUN
dti-1373	292	32	cells	cell	NOUN
dti-1373	292	33	highlight	highlight	VERB
dti-1373	292	34	the	the	DET
dti-1373	292	35	antiangiogenic	antiangiogenic	ADJ
dti-1373	292	36	properties	property	NOUN
dti-1373	292	37	of	of	ADP
dti-1373	292	38	a	a	DET
dti-1373	292	39	mumbaistatin	mumbaistatin	ADJ
dti-1373	292	40	analog	analog	NOUN
dti-1373	292	41	.	.	PUNCT
dti-1373	293	1	chem	chem	NOUN
dti-1373	293	2	biol	biol	PROPN
dti-1373	293	3	drug	drug	PROPN
dti-1373	293	4	des	des	PROPN
dti-1373	293	5	.	.	PROPN
dti-1373	293	6	2010;75:481–8	2010;75:481–8	NUM
dti-1373	293	7	.	.	PUNCT
dti-1373	294	1	27	27	NUM
dti-1373	294	2	.	.	PUNCT
dti-1373	295	1	annabi	annabi	PROPN
dti-1373	295	2	b	b	PROPN
dti-1373	295	3	,	,	PUNCT
dti-1373	295	4	vaillancourt	vaillancourt	NOUN
dti-1373	295	5	-	-	PUNCT
dti-1373	295	6	jean	jean	PROPN
dti-1373	295	7	e	e	PROPN
dti-1373	295	8	,	,	PUNCT
dti-1373	295	9	weil	weil	PROPN
dti-1373	295	10	ag	ag	PROPN
dti-1373	295	11	,	,	PUNCT
dti-1373	295	12	béliveau	béliveau	PROPN
dti-1373	295	13	r.	r.	PROPN
dti-1373	295	14	pharmacological	pharmacological	PROPN
dti-1373	295	15	targeting	targeting	NOUN
dti-1373	295	16	of	of	ADP
dti-1373	295	17	β	β	ADJ
dti-1373	295	18	-	-	ADJ
dti-1373	295	19	adrenergic	adrenergic	ADJ
dti-1373	295	20	receptor	receptor	NOUN
dti-1373	295	21	functions	function	NOUN
dti-1373	295	22	abrogates	abrogate	VERB
dti-1373	295	23	nf	nf	ADJ
dti-1373	295	24	-	-	PUNCT
dti-1373	295	25	κb	κb	NOUN
dti-1373	295	26	signaling	signal	VERB
dti-1373	295	27	and	and	CCONJ
dti-1373	295	28	mmp-9	mmp-9	NOUN
dti-1373	295	29	secretion	secretion	NOUN
dti-1373	295	30	in	in	ADP
dti-1373	295	31	medulloblastoma	medulloblastoma	ADJ
dti-1373	295	32	cells	cell	NOUN
dti-1373	295	33	.	.	PUNCT
dti-1373	296	1	onco	onco	NOUN
dti-1373	296	2	targets	target	NOUN
dti-1373	296	3	ther	ther	ADV
dti-1373	296	4	.	.	PUNCT
dti-1373	297	1	2010;3	2010;3	NOUN
dti-1373	297	2	:	:	PUNCT
dti-1373	297	3	219–26	219–26	NUM
dti-1373	297	4	.	.	PUNCT
dti-1373	298	1	28	28	NUM
dti-1373	298	2	.	.	PUNCT
dti-1373	299	1	dong	dong	PROPN
dti-1373	299	2	j	j	PROPN
dti-1373	299	3	,	,	PUNCT
dti-1373	299	4	jimi	jimi	PROPN
dti-1373	299	5	e	e	PROPN
dti-1373	299	6	,	,	PUNCT
dti-1373	299	7	zeiss	zeiss	PROPN
dti-1373	299	8	c	c	X
dti-1373	299	9	,	,	PUNCT
dti-1373	299	10	hayden	hayden	PROPN
dti-1373	299	11	ms	ms	PROPN
dti-1373	299	12	,	,	PUNCT
dti-1373	299	13	ghosh	ghosh	PROPN
dti-1373	299	14	s.	s.	PROPN
dti-1373	299	15	constitutively	constitutively	ADV
dti-1373	299	16	active	active	ADJ
dti-1373	299	17	nfkappab	nfkappab	NOUN
dti-1373	299	18	triggers	trigger	VERB
dti-1373	299	19	systemic	systemic	ADJ
dti-1373	299	20	tnfalpha	tnfalpha	NOUN
dti-1373	299	21	-	-	PUNCT
dti-1373	299	22	dependent	dependent	ADJ
dti-1373	299	23	inflammation	inflammation	NOUN
dti-1373	299	24	and	and	CCONJ
dti-1373	299	25	localized	localized	ADJ
dti-1373	299	26	tnfalpha	tnfalpha	NOUN
dti-1373	299	27	-	-	PUNCT
dti-1373	299	28	independent	independent	ADJ
dti-1373	299	29	inflammatory	inflammatory	ADJ
dti-1373	299	30	disease	disease	NOUN
dti-1373	299	31	.	.	PUNCT
dti-1373	300	1	genes	gene	NOUN
dti-1373	300	2	dev	dev	PROPN
dti-1373	300	3	.	.	PUNCT
dti-1373	301	1	2010;24	2010;24	NUM
dti-1373	301	2	:	:	PUNCT
dti-1373	301	3	1709–17	1709–17	NUM
dti-1373	301	4	.	.	PUNCT
dti-1373	302	1	29	29	NUM
dti-1373	302	2	.	.	X
dti-1373	302	3	solt	solt	PROPN
dti-1373	302	4	la	la	PROPN
dti-1373	302	5	,	,	PUNCT
dti-1373	302	6	may	may	AUX
dti-1373	302	7	mj	mj	VERB
dti-1373	302	8	.	.	PUNCT
dti-1373	303	1	the	the	DET
dti-1373	303	2	ikappab	ikappab	PROPN
dti-1373	303	3	kinase	kinase	PROPN
dti-1373	303	4	complex	complex	PROPN
dti-1373	303	5	:	:	PUNCT
dti-1373	303	6	master	master	NOUN
dti-1373	303	7	regulator	regulator	NOUN
dti-1373	303	8	of	of	ADP
dti-1373	303	9	nfkappab	nfkappab	NOUN
dti-1373	303	10	signalling	signal	VERB
dti-1373	303	11	.	.	PUNCT
dti-1373	304	1	immunol	immunol	NOUN
dti-1373	304	2	res	re	NOUN
dti-1373	304	3	.	.	PUNCT
dti-1373	305	1	2008;42:3–18	2008;42:3–18	NUM
dti-1373	305	2	.	.	PUNCT
dti-1373	306	1	30	30	NUM
dti-1373	306	2	.	.	PUNCT
dti-1373	307	1	craggs	craggs	PROPN
dti-1373	307	2	l	l	PROPN
dti-1373	307	3	,	,	PUNCT
dti-1373	307	4	kalaria	kalaria	PROPN
dti-1373	307	5	rn	rn	PROPN
dti-1373	307	6	.	.	PUNCT
dti-1373	307	7	revisiting	revisit	VERB
dti-1373	307	8	dietary	dietary	ADJ
dti-1373	307	9	antioxidants	antioxidant	NOUN
dti-1373	307	10	,	,	PUNCT
dti-1373	307	11	neurodegeneration	neurodegeneration	NOUN
dti-1373	307	12	and	and	CCONJ
dti-1373	307	13	dementia	dementia	NOUN
dti-1373	307	14	.	.	PUNCT
dti-1373	308	1	neuroreport	neuroreport	NOUN
dti-1373	308	2	.	.	PUNCT
dti-1373	309	1	2011;22:1–3	2011;22:1–3	NUM
dti-1373	309	2	.	.	PUNCT
dti-1373	310	1	31	31	NUM
dti-1373	310	2	.	.	PUNCT
dti-1373	310	3	boocock	boocock	NOUN
dti-1373	310	4	dj	dj	PROPN
dti-1373	310	5	,	,	PUNCT
dti-1373	310	6	patel	patel	PROPN
dti-1373	310	7	kr	kr	PROPN
dti-1373	310	8	,	,	PUNCT
dti-1373	310	9	faust	faust	PROPN
dti-1373	310	10	ge	ge	PROPN
dti-1373	310	11	,	,	PUNCT
dti-1373	310	12	et	et	PROPN
dti-1373	310	13	al	al	PROPN
dti-1373	310	14	.	.	PUNCT
dti-1373	310	15	quantitation	quantitation	NOUN
dti-1373	310	16	of	of	ADP
dti-1373	310	17	trans	tran	NOUN
dti-1373	310	18	-	-	NOUN
dti-1373	310	19	resveratrol	resveratrol	NOUN
dti-1373	310	20	and	and	CCONJ
dti-1373	310	21	detection	detection	NOUN
dti-1373	310	22	of	of	ADP
dti-1373	310	23	its	its	PRON
dti-1373	310	24	metabolites	metabolite	NOUN
dti-1373	310	25	in	in	ADP
dti-1373	310	26	human	human	ADJ
dti-1373	310	27	plasma	plasma	NOUN
dti-1373	310	28	and	and	CCONJ
dti-1373	310	29	urine	urine	NOUN
dti-1373	310	30	by	by	ADP
dti-1373	310	31	high	high	ADJ
dti-1373	310	32	performance	performance	NOUN
dti-1373	310	33	liquid	liquid	NOUN
dti-1373	310	34	chromatography	chromatography	NOUN
dti-1373	310	35	.	.	PUNCT
dti-1373	311	1	j	j	PROPN
dti-1373	311	2	chromatogr	chromatogr	PROPN
dti-1373	311	3	b	b	PROPN
dti-1373	311	4	analyt	analyt	PROPN
dti-1373	311	5	technol	technol	PROPN
dti-1373	311	6	biomed	biome	VERB
dti-1373	311	7	life	life	NOUN
dti-1373	311	8	sci	sci	PROPN
dti-1373	311	9	.	.	PUNCT
dti-1373	312	1	2007;848:182–7	2007;848:182–7	PROPN
dti-1373	312	2	.	.	PUNCT
dti-1373	313	1	32	32	NUM
dti-1373	313	2	.	.	PUNCT
dti-1373	314	1	meng	meng	PROPN
dti-1373	314	2	x	x	PROPN
dti-1373	314	3	,	,	PUNCT
dti-1373	314	4	maliakal	maliakal	NOUN
dti-1373	314	5	p	p	NOUN
dti-1373	314	6	,	,	PUNCT
dti-1373	314	7	lu	lu	PROPN
dti-1373	314	8	h	h	NOUN
dti-1373	314	9	,	,	PUNCT
dti-1373	314	10	lee	lee	PROPN
dti-1373	314	11	mj	mj	PROPN
dti-1373	314	12	,	,	PUNCT
dti-1373	314	13	yang	yang	PROPN
dti-1373	314	14	cs	cs	PROPN
dti-1373	314	15	.	.	PROPN
dti-1373	314	16	urinary	urinary	ADJ
dti-1373	314	17	and	and	CCONJ
dti-1373	314	18	plasma	plasma	NOUN
dti-1373	314	19	levels	level	NOUN
dti-1373	314	20	of	of	ADP
dti-1373	314	21	resveratrol	resveratrol	NOUN
dti-1373	314	22	and	and	CCONJ
dti-1373	314	23	quercetin	quercetin	NOUN
dti-1373	314	24	in	in	ADP
dti-1373	314	25	humans	human	NOUN
dti-1373	314	26	,	,	PUNCT
dti-1373	314	27	mice	mouse	NOUN
dti-1373	314	28	,	,	PUNCT
dti-1373	314	29	and	and	CCONJ
dti-1373	314	30	rats	rat	NOUN
dti-1373	314	31	after	after	ADP
dti-1373	314	32	ingestion	ingestion	NOUN
dti-1373	314	33	of	of	ADP
dti-1373	314	34	pure	pure	ADJ
dti-1373	314	35	compounds	compound	NOUN
dti-1373	314	36	and	and	CCONJ
dti-1373	314	37	grape	grape	NOUN
dti-1373	314	38	juice	juice	NOUN
dti-1373	314	39	.	.	PUNCT
dti-1373	315	1	j	j	PROPN
dti-1373	315	2	agric	agric	PROPN
dti-1373	315	3	food	food	PROPN
dti-1373	315	4	chem	chem	NOUN
dti-1373	315	5	.	.	PUNCT
dti-1373	316	1	2004;52:935–42	2004;52:935–42	NUM
dti-1373	316	2	.	.	PROPN
dti-1373	316	3	33	33	NUM
dti-1373	316	4	.	.	PUNCT
dti-1373	317	1	bishayee	bishayee	ADV
dti-1373	317	2	a	a	DET
dti-1373	317	3	,	,	PUNCT
dti-1373	317	4	waghray	waghray	ADJ
dti-1373	317	5	a	a	PRON
dti-1373	317	6	,	,	PUNCT
dti-1373	317	7	barnes	barnes	PROPN
dti-1373	317	8	kf	kf	PROPN
dti-1373	317	9	,	,	PUNCT
dti-1373	317	10	et	et	PROPN
dti-1373	317	11	al	al	PROPN
dti-1373	317	12	.	.	PROPN
dti-1373	317	13	suppression	suppression	NOUN
dti-1373	317	14	of	of	ADP
dti-1373	317	15	the	the	DET
dti-1373	317	16	inflammatory	inflammatory	ADJ
dti-1373	317	17	cascade	cascade	NOUN
dti-1373	317	18	is	be	AUX
dti-1373	317	19	implicated	implicate	VERB
dti-1373	317	20	in	in	ADP
dti-1373	317	21	resveratrol	resveratrol	NOUN
dti-1373	317	22	chemoprevention	chemoprevention	NOUN
dti-1373	317	23	of	of	ADP
dti-1373	317	24	experimental	experimental	ADJ
dti-1373	317	25	hepatocarcinogenesis	hepatocarcinogenesis	NOUN
dti-1373	317	26	.	.	PUNCT
dti-1373	318	1	pharm	pharm	NOUN
dti-1373	318	2	res	re	NOUN
dti-1373	318	3	.	.	PUNCT
dti-1373	319	1	2010;27:1080–91	2010;27:1080–91	NUM
dti-1373	319	2	.	.	PUNCT
dti-1373	320	1	34	34	NUM
dti-1373	320	2	.	.	PUNCT
dti-1373	321	1	boily	boily	PROPN
dti-1373	321	2	g	g	PROPN
dti-1373	321	3	,	,	PUNCT
dti-1373	321	4	he	he	PRON
dti-1373	321	5	xh	xh	PROPN
dti-1373	321	6	,	,	PUNCT
dti-1373	321	7	pearce	pearce	PROPN
dti-1373	321	8	b	b	PROPN
dti-1373	321	9	,	,	PUNCT
dti-1373	321	10	jardine	jardine	PROPN
dti-1373	321	11	k	k	PROPN
dti-1373	321	12	,	,	PUNCT
dti-1373	321	13	mcburney	mcburney	PROPN
dti-1373	321	14	mw	mw	PROPN
dti-1373	321	15	.	.	PROPN
dti-1373	321	16	sirt1	sirt1	ADJ
dti-1373	321	17	-	-	ADJ
dti-1373	321	18	null	null	ADJ
dti-1373	321	19	mice	mouse	NOUN
dti-1373	321	20	develop	develop	VERB
dti-1373	321	21	tumors	tumor	NOUN
dti-1373	321	22	at	at	ADP
dti-1373	321	23	normal	normal	ADJ
dti-1373	321	24	rates	rate	NOUN
dti-1373	321	25	but	but	CCONJ
dti-1373	321	26	are	be	AUX
dti-1373	321	27	poorly	poorly	ADV
dti-1373	321	28	protected	protect	VERB
dti-1373	321	29	by	by	ADP
dti-1373	321	30	resveratrol	resveratrol	NOUN
dti-1373	321	31	.	.	PUNCT
dti-1373	322	1	oncogene	oncogene	NOUN
dti-1373	322	2	.	.	PUNCT
dti-1373	323	1	2009;28:2882–9283	2009;28:2882–9283	NUM
dti-1373	323	2	.	.	PUNCT
dti-1373	324	1	35	35	NUM
dti-1373	324	2	.	.	PUNCT
dti-1373	325	1	pfister	pfister	PROPN
dti-1373	325	2	ja	ja	PROPN
dti-1373	325	3	,	,	PUNCT
dti-1373	325	4	ma	ma	PROPN
dti-1373	325	5	c	c	PROPN
dti-1373	325	6	,	,	PUNCT
dti-1373	325	7	morrison	morrison	PROPN
dti-1373	325	8	be	be	PROPN
dti-1373	325	9	,	,	PUNCT
dti-1373	325	10	d’mello	d’mello	PROPN
dti-1373	325	11	sr	sr	PROPN
dti-1373	325	12	.	.	PUNCT
dti-1373	326	1	opposing	oppose	VERB
dti-1373	326	2	effects	effect	NOUN
dti-1373	326	3	of	of	ADP
dti-1373	326	4	sirtuins	sirtuin	NOUN
dti-1373	326	5	on	on	ADP
dti-1373	326	6	neuronal	neuronal	ADJ
dti-1373	326	7	survival	survival	NOUN
dti-1373	326	8	:	:	PUNCT
dti-1373	326	9	sirt1	sirt1	ADJ
dti-1373	326	10	-	-	PUNCT
dti-1373	326	11	mediated	mediate	VERB
dti-1373	326	12	neuroprotection	neuroprotection	NOUN
dti-1373	326	13	is	be	AUX
dti-1373	326	14	independent	independent	ADJ
dti-1373	326	15	of	of	ADP
dti-1373	326	16	its	its	PRON
dti-1373	326	17	deacetylase	deacetylase	NOUN
dti-1373	326	18	activity	activity	NOUN
dti-1373	326	19	.	.	PUNCT
dti-1373	327	1	plos	plos	PROPN
dti-1373	327	2	one	one	NUM
dti-1373	327	3	.	.	PUNCT
dti-1373	328	1	2008;3	2008;3	NUM
dti-1373	328	2	:	:	PUNCT
dti-1373	328	3	e4090	e4090	NUM
dti-1373	328	4	.	.	NOUN
dti-1373	329	1	36	36	NUM
dti-1373	329	2	.	.	PUNCT
dti-1373	330	1	howitz	howitz	PROPN
dti-1373	330	2	kt	kt	PROPN
dti-1373	330	3	,	,	PUNCT
dti-1373	330	4	bitterman	bitterman	PROPN
dti-1373	330	5	kj	kj	PROPN
dti-1373	330	6	,	,	PUNCT
dti-1373	330	7	cohen	cohen	PROPN
dti-1373	330	8	hy	hy	PROPN
dti-1373	330	9	,	,	PUNCT
dti-1373	330	10	et	et	PROPN
dti-1373	330	11	al	al	PROPN
dti-1373	330	12	.	.	PUNCT
dti-1373	330	13	small	small	ADJ
dti-1373	330	14	molecule	molecule	NOUN
dti-1373	330	15	activators	activator	NOUN
dti-1373	330	16	of	of	ADP
dti-1373	330	17	sirtuins	sirtuin	NOUN
dti-1373	330	18	extend	extend	VERB
dti-1373	330	19	saccharomyces	saccharomyce	NOUN
dti-1373	330	20	cerevisiae	cerevisiae	NOUN
dti-1373	330	21	lifespan	lifespan	NOUN
dti-1373	330	22	.	.	PUNCT
dti-1373	331	1	nature	nature	NOUN
dti-1373	331	2	.	.	PUNCT
dti-1373	332	1	2003;425	2003;425	NUM
dti-1373	332	2	:	:	PUNCT
dti-1373	332	3	191–6	191–6	NUM
dti-1373	332	4	.	.	NOUN
dti-1373	332	5	37	37	NUM
dti-1373	332	6	.	.	PUNCT
dti-1373	333	1	knutson	knutson	PROPN
dti-1373	333	2	md	md	PROPN
dti-1373	333	3	,	,	PUNCT
dti-1373	333	4	leeuwenburgh	leeuwenburgh	PROPN
dti-1373	333	5	c.	c.	PROPN
dti-1373	333	6	resveratrol	resveratrol	NOUN
dti-1373	333	7	and	and	CCONJ
dti-1373	333	8	novel	novel	ADJ
dti-1373	333	9	potent	potent	ADJ
dti-1373	333	10	activators	activator	NOUN
dti-1373	333	11	of	of	ADP
dti-1373	333	12	sirt1	sirt1	NOUN
dti-1373	333	13	:	:	PUNCT
dti-1373	333	14	effects	effect	NOUN
dti-1373	333	15	on	on	ADP
dti-1373	333	16	aging	aging	NOUN
dti-1373	333	17	and	and	CCONJ
dti-1373	333	18	age	age	NOUN
dti-1373	333	19	-	-	PUNCT
dti-1373	333	20	related	relate	VERB
dti-1373	333	21	diseases	disease	NOUN
dti-1373	333	22	.	.	PUNCT
dti-1373	334	1	nutr	nutr	PROPN
dti-1373	334	2	rev	rev	PROPN
dti-1373	334	3	.	.	PROPN
dti-1373	334	4	2008;6:591–6	2008;6:591–6	NOUN
dti-1373	334	5	.	.	PUNCT
dti-1373	335	1	38	38	NUM
dti-1373	335	2	.	.	PUNCT
dti-1373	336	1	anekonda	anekonda	PROPN
dti-1373	336	2	ts	ts	PROPN
dti-1373	336	3	.	.	PUNCT
dti-1373	337	1	resveratrol	resveratrol	NOUN
dti-1373	337	2	--	--	PUNCT
dti-1373	337	3	a	a	DET
dti-1373	337	4	boon	boon	NOUN
dti-1373	337	5	for	for	ADP
dti-1373	337	6	treating	treat	VERB
dti-1373	337	7	alzheimer	alzheimer	PROPN
dti-1373	337	8	’s	’s	PART
dti-1373	337	9	disease	disease	NOUN
dti-1373	337	10	?	?	PUNCT
dti-1373	338	1	brain	brain	NOUN
dti-1373	338	2	res	re	NOUN
dti-1373	338	3	rev	rev	PROPN
dti-1373	338	4	.	.	PUNCT
dti-1373	339	1	2006;52:316–236	2006;52:316–236	NUM
dti-1373	339	2	.	.	PUNCT
dti-1373	340	1	39	39	NUM
dti-1373	340	2	.	.	PUNCT
dti-1373	341	1	van	van	PROPN
dti-1373	341	2	acker	acker	PROPN
dti-1373	341	3	sa	sa	PROPN
dti-1373	341	4	,	,	PUNCT
dti-1373	341	5	tromp	tromp	PROPN
dti-1373	341	6	mn	mn	PROPN
dti-1373	341	7	,	,	PUNCT
dti-1373	341	8	haenen	haenen	PROPN
dti-1373	341	9	gr	gr	PROPN
dti-1373	341	10	,	,	PUNCT
dti-1373	341	11	van	van	PROPN
dti-1373	341	12	der	der	NOUN
dti-1373	341	13	vijgh	vijgh	PROPN
dti-1373	341	14	wj	wj	PROPN
dti-1373	341	15	,	,	PUNCT
dti-1373	341	16	bast	bast	ADJ
dti-1373	341	17	a.	a.	NOUN
dti-1373	341	18	flavonoids	flavonoid	NOUN
dti-1373	341	19	as	as	ADP
dti-1373	341	20	scavengers	scavenger	NOUN
dti-1373	341	21	of	of	ADP
dti-1373	341	22	nitric	nitric	ADJ
dti-1373	341	23	oxide	oxide	NOUN
dti-1373	341	24	radical	radical	NOUN
dti-1373	341	25	.	.	PUNCT
dti-1373	342	1	biochem	biochem	PROPN
dti-1373	342	2	biophys	biophys	PROPN
dti-1373	342	3	res	re	NOUN
dti-1373	342	4	commun	commun	PROPN
dti-1373	342	5	.	.	PUNCT
dti-1373	343	1	1995;214:755–9	1995;214:755–9	PROPN
dti-1373	343	2	.	.	PUNCT
dti-1373	344	1	40	40	NUM
dti-1373	344	2	.	.	PUNCT
dti-1373	345	1	laughton	laughton	PROPN
dti-1373	345	2	mj	mj	PROPN
dti-1373	345	3	,	,	PUNCT
dti-1373	345	4	evans	evans	PROPN
dti-1373	345	5	pj	pj	PROPN
dti-1373	345	6	,	,	PUNCT
dti-1373	345	7	moroney	moroney	PROPN
dti-1373	345	8	ma	ma	PROPN
dti-1373	345	9	,	,	PUNCT
dti-1373	345	10	hoult	hoult	PROPN
dti-1373	345	11	jr	jr	PROPN
dti-1373	345	12	,	,	PUNCT
dti-1373	345	13	halliwell	halliwell	PROPN
dti-1373	345	14	b.	b.	PROPN
dti-1373	345	15	inhibition	inhibition	NOUN
dti-1373	345	16	of	of	ADP
dti-1373	345	17	mammalian	mammalian	ADJ
dti-1373	345	18	5	5	NUM
dti-1373	345	19	-	-	PUNCT
dti-1373	345	20	lipoxygenase	lipoxygenase	NOUN
dti-1373	345	21	and	and	CCONJ
dti-1373	345	22	cyclo	cyclo	NOUN
dti-1373	345	23	-	-	PUNCT
dti-1373	345	24	oxygenase	oxygenase	NOUN
dti-1373	345	25	by	by	ADP
dti-1373	345	26	flavonoids	flavonoid	NOUN
dti-1373	345	27	and	and	CCONJ
dti-1373	345	28	phenolic	phenolic	ADJ
dti-1373	345	29	dietary	dietary	ADJ
dti-1373	345	30	additives	additive	NOUN
dti-1373	345	31	.	.	PUNCT
dti-1373	346	1	relationship	relationship	NOUN
dti-1373	346	2	to	to	ADP
dti-1373	346	3	antioxidant	antioxidant	ADJ
dti-1373	346	4	activity	activity	NOUN
dti-1373	346	5	and	and	CCONJ
dti-1373	346	6	to	to	PART
dti-1373	346	7	iron	iron	VERB
dti-1373	346	8	ion	ion	NOUN
dti-1373	346	9	-	-	PUNCT
dti-1373	346	10	reducing	reduce	VERB
dti-1373	346	11	ability	ability	NOUN
dti-1373	346	12	.	.	PUNCT
dti-1373	347	1	biochem	biochem	PROPN
dti-1373	347	2	pharmacol	pharmacol	PROPN
dti-1373	347	3	.	.	PUNCT
dti-1373	348	1	1991;42:1673–81	1991;42:1673–81	NUM
dti-1373	348	2	.	.	NOUN
dti-1373	349	1	41	41	NUM
dti-1373	349	2	.	.	PUNCT
dti-1373	350	1	nakamaru	nakamaru	PROPN
dti-1373	350	2	y	y	PROPN
dti-1373	350	3	,	,	PUNCT
dti-1373	350	4	vuppusetty	vuppusetty	NOUN
dti-1373	350	5	c	c	NOUN
dti-1373	350	6	,	,	PUNCT
dti-1373	350	7	wada	wada	PROPN
dti-1373	350	8	h	h	PROPN
dti-1373	350	9	,	,	PUNCT
dti-1373	350	10	et	et	PROPN
dti-1373	350	11	al	al	PROPN
dti-1373	350	12	.	.	PUNCT
dti-1373	351	1	a	a	DET
dti-1373	351	2	protein	protein	NOUN
dti-1373	351	3	deacetylase	deacetylase	NOUN
dti-1373	351	4	sirt1	sirt1	NOUN
dti-1373	351	5	is	be	AUX
dti-1373	351	6	a	a	DET
dti-1373	351	7	negative	negative	ADJ
dti-1373	351	8	regulator	regulator	NOUN
dti-1373	351	9	of	of	ADP
dti-1373	351	10	metalloproteinase-9	metalloproteinase-9	PROPN
dti-1373	351	11	.	.	PROPN
dti-1373	352	1	faseb	faseb	PROPN
dti-1373	352	2	j.	j.	PROPN
dti-1373	352	3	2009;23:2810–9	2009;23:2810–9	PROPN
dti-1373	352	4	.	.	PUNCT
dti-1373	353	1	42	42	NUM
dti-1373	353	2	.	.	PUNCT
dti-1373	354	1	woo	woo	VERB
dti-1373	354	2	jh	jh	PROPN
dti-1373	354	3	,	,	PUNCT
dti-1373	354	4	lim	lim	PROPN
dti-1373	354	5	jh	jh	PROPN
dti-1373	354	6	,	,	PUNCT
dti-1373	354	7	kim	kim	PROPN
dti-1373	354	8	yh	yh	PROPN
dti-1373	354	9	,	,	PUNCT
dti-1373	355	1	et	et	PROPN
dti-1373	355	2	al	al	PROPN
dti-1373	355	3	.	.	PROPN
dti-1373	355	4	resveratrol	resveratrol	NOUN
dti-1373	355	5	inhibits	inhibit	VERB
dti-1373	355	6	phorbol	phorbol	NOUN
dti-1373	355	7	myristate	myristate	ADJ
dti-1373	355	8	acetate	acetate	NOUN
dti-1373	355	9	-	-	PUNCT
dti-1373	355	10	induced	induce	VERB
dti-1373	355	11	matrix	matrix	NOUN
dti-1373	355	12	metalloproteinase-9	metalloproteinase-9	NUM
dti-1373	355	13	expression	expression	NOUN
dti-1373	355	14	by	by	ADP
dti-1373	355	15	inhibiting	inhibit	VERB
dti-1373	355	16	jnk	jnk	PROPN
dti-1373	355	17	and	and	CCONJ
dti-1373	355	18	pkc	pkc	PROPN
dti-1373	355	19	delta	delta	PROPN
dti-1373	355	20	signal	signal	PROPN
dti-1373	355	21	transduction	transduction	NOUN
dti-1373	355	22	.	.	PUNCT
dti-1373	356	1	oncogene	oncogene	NOUN
dti-1373	356	2	.	.	PUNCT
dti-1373	357	1	2004;23:1845–53	2004;23:1845–53	NUM
dti-1373	357	2	.	.	PUNCT
dti-1373	358	1	43	43	NUM
dti-1373	358	2	.	.	PUNCT
dti-1373	359	1	gao	gao	PROPN
dti-1373	359	2	z	z	PROPN
dti-1373	359	3	,	,	PUNCT
dti-1373	359	4	ye	ye	PRON
dti-1373	359	5	j.	j.	PROPN
dti-1373	359	6	inhibition	inhibition	NOUN
dti-1373	359	7	of	of	ADP
dti-1373	359	8	transcriptional	transcriptional	ADJ
dti-1373	359	9	activity	activity	NOUN
dti-1373	359	10	of	of	ADP
dti-1373	359	11	c	c	PROPN
dti-1373	359	12	-	-	PUNCT
dti-1373	359	13	jun	jun	PROPN
dti-1373	359	14	by	by	ADP
dti-1373	359	15	sirt1	sirt1	PROPN
dti-1373	359	16	.	.	PUNCT
dti-1373	360	1	biochem	biochem	PROPN
dti-1373	360	2	biophys	biophy	VERB
dti-1373	360	3	res	re	NOUN
dti-1373	360	4	commun	commun	PROPN
dti-1373	360	5	.	.	PUNCT
dti-1373	361	1	2008;376:793–6	2008;376:793–6	NUM
dti-1373	361	2	.	.	PUNCT
dti-1373	362	1	44	44	NUM
dti-1373	362	2	.	.	PUNCT
dti-1373	363	1	in	in	ADP
dti-1373	363	2	:	:	PUNCT
dti-1373	363	3	rice	rice	PROPN
dti-1373	363	4	-	-	PUNCT
dti-1373	363	5	evans	evans	PROPN
dti-1373	363	6	c	c	PROPN
dti-1373	363	7	,	,	PUNCT
dti-1373	363	8	packer	packer	PROPN
dti-1373	363	9	l	l	PROPN
dti-1373	363	10	,	,	PUNCT
dti-1373	363	11	editors	editor	NOUN
dti-1373	363	12	:	:	PUNCT
dti-1373	363	13	flavonoids	flavonoid	NOUN
dti-1373	363	14	in	in	ADP
dti-1373	363	15	health	health	NOUN
dti-1373	363	16	and	and	CCONJ
dti-1373	363	17	disease	disease	NOUN
dti-1373	363	18	(	(	PUNCT
dti-1373	363	19	second	second	ADJ
dti-1373	363	20	ed	ed	NOUN
dti-1373	363	21	.	.	PUNCT
dti-1373	363	22	)	)	PUNCT
dti-1373	363	23	,	,	PUNCT
dti-1373	363	24	marcel	marcel	PROPN
dti-1373	363	25	dekker	dekker	PROPN
dti-1373	363	26	inc	inc	PROPN
dti-1373	363	27	,	,	PUNCT
dti-1373	363	28	new	new	PROPN
dti-1373	363	29	york	york	PROPN
dti-1373	363	30	/	/	SYM
dti-1373	363	31	basel	basel	PROPN
dti-1373	363	32	(	(	PUNCT
dti-1373	363	33	2003	2003	NUM
dti-1373	363	34	)	)	PUNCT
dti-1373	363	35	.	.	PUNCT
dti-1373	364	1	45	45	NUM
dti-1373	364	2	.	.	PUNCT
dti-1373	365	1	walle	walle	PROPN
dti-1373	365	2	t	t	PROPN
dti-1373	365	3	,	,	PUNCT
dti-1373	365	4	hsieh	hsieh	PROPN
dti-1373	365	5	f	f	PROPN
dti-1373	365	6	,	,	PUNCT
dti-1373	365	7	delegge	delegge	PROPN
dti-1373	365	8	mh	mh	PROPN
dti-1373	365	9	,	,	PUNCT
dti-1373	365	10	oatis	oatis	PROPN
dti-1373	365	11	je	je	PROPN
dti-1373	365	12	jr	jr	PROPN
dti-1373	365	13	,	,	PUNCT
dti-1373	365	14	walle	walle	PROPN
dti-1373	365	15	uk	uk	PROPN
dti-1373	365	16	.	.	PROPN
dti-1373	365	17	high	high	ADJ
dti-1373	365	18	absorption	absorption	NOUN
dti-1373	365	19	but	but	CCONJ
dti-1373	365	20	very	very	ADV
dti-1373	365	21	low	low	ADJ
dti-1373	365	22	bioavailability	bioavailability	NOUN
dti-1373	365	23	of	of	ADP
dti-1373	365	24	oral	oral	ADJ
dti-1373	365	25	resveratrol	resveratrol	NOUN
dti-1373	365	26	in	in	ADP
dti-1373	365	27	humans	human	NOUN
dti-1373	365	28	.	.	PUNCT
dti-1373	366	1	drug	drug	NOUN
dti-1373	366	2	metab	metab	PROPN
dti-1373	366	3	dispos	dispos	PROPN
dti-1373	366	4	.	.	PUNCT
dti-1373	367	1	2004;32:1377–82	2004;32:1377–82	NUM
dti-1373	367	2	.	.	PUNCT
dti-1373	367	3	http://www.la-press.com	http://www.la-press.com	X
dti-1373	368	1	sirt1	sirt1	NOUN
dti-1373	368	2	expression	expression	NOUN
dti-1373	368	3	in	in	ADP
dti-1373	368	4	inflammatory	inflammatory	ADJ
dti-1373	368	5	cerebral	cerebral	ADJ
dti-1373	368	6	endothelium	endothelium	NOUN
dti-1373	368	7	drug	drug	NOUN
dti-1373	368	8	target	target	NOUN
dti-1373	368	9	insights	insight	NOUN
dti-1373	368	10	2012:6	2012:6	NUM
dti-1373	368	11	11	11	NUM
dti-1373	368	12	46	46	NUM
dti-1373	368	13	.	.	PUNCT
dti-1373	369	1	marier	marier	PROPN
dti-1373	369	2	jf	jf	PROPN
dti-1373	369	3	,	,	PUNCT
dti-1373	369	4	vachon	vachon	PROPN
dti-1373	370	1	p	p	NOUN
dti-1373	370	2	,	,	PUNCT
dti-1373	370	3	gritsas	gritsa	NOUN
dti-1373	370	4	a	a	X
dti-1373	370	5	,	,	PUNCT
dti-1373	370	6	zhang	zhang	PROPN
dti-1373	370	7	j	j	PROPN
dti-1373	370	8	,	,	PUNCT
dti-1373	370	9	moreau	moreau	PROPN
dti-1373	370	10	jp	jp	PROPN
dti-1373	370	11	,	,	PUNCT
dti-1373	370	12	ducharme	ducharme	PROPN
dti-1373	370	13	mp	mp	PROPN
dti-1373	370	14	.	.	PUNCT
dti-1373	370	15	metabolism	metabolism	NOUN
dti-1373	370	16	and	and	CCONJ
dti-1373	370	17	disposition	disposition	NOUN
dti-1373	370	18	of	of	ADP
dti-1373	370	19	resveratrol	resveratrol	NOUN
dti-1373	370	20	in	in	ADP
dti-1373	370	21	rats	rat	NOUN
dti-1373	370	22	:	:	PUNCT
dti-1373	370	23	extent	extent	NOUN
dti-1373	370	24	of	of	ADP
dti-1373	370	25	absorption	absorption	NOUN
dti-1373	370	26	,	,	PUNCT
dti-1373	370	27	glucuronidation	glucuronidation	NOUN
dti-1373	370	28	,	,	PUNCT
dti-1373	370	29	and	and	CCONJ
dti-1373	370	30	enterohepatic	enterohepatic	ADJ
dti-1373	370	31	recirculation	recirculation	NOUN
dti-1373	370	32	evidenced	evidence	VERB
dti-1373	370	33	by	by	ADP
dti-1373	370	34	a	a	DET
dti-1373	370	35	linked	link	VERB
dti-1373	370	36	-	-	PUNCT
dti-1373	370	37	rat	rat	NOUN
dti-1373	370	38	model	model	NOUN
dti-1373	370	39	.	.	PUNCT
dti-1373	371	1	j	j	PROPN
dti-1373	371	2	pharmacol	pharmacol	PROPN
dti-1373	371	3	exp	exp	NOUN
dti-1373	371	4	ther	ther	ADV
dti-1373	371	5	.	.	PUNCT
dti-1373	372	1	2002;302:369–73	2002;302:369–73	X
dti-1373	372	2	.	.	PUNCT
dti-1373	373	1	47	47	NUM
dti-1373	373	2	.	.	PUNCT
dti-1373	374	1	abd	abd	PROPN
dti-1373	374	2	el	el	PROPN
dti-1373	374	3	-	-	PROPN
dti-1373	374	4	mohsen	mohsen	PROPN
dti-1373	374	5	m	m	PROPN
dti-1373	374	6	,	,	PUNCT
dti-1373	374	7	bayele	bayele	PROPN
dti-1373	374	8	h	h	NOUN
dti-1373	374	9	,	,	PUNCT
dti-1373	374	10	kuhnle	kuhnle	VERB
dti-1373	374	11	g	g	PROPN
dti-1373	374	12	,	,	PUNCT
dti-1373	374	13	et	et	PROPN
dti-1373	374	14	al	al	PROPN
dti-1373	374	15	.	.	PUNCT
dti-1373	374	16	distribution	distribution	NOUN
dti-1373	374	17	of	of	ADP
dti-1373	374	18	[	[	X
dti-1373	374	19	3h]transresveratrol	3h]transresveratrol	PROPN
dti-1373	374	20	in	in	ADP
dti-1373	374	21	rat	rat	NOUN
dti-1373	374	22	tissues	tissue	NOUN
dti-1373	374	23	following	follow	VERB
dti-1373	374	24	oral	oral	ADJ
dti-1373	374	25	administration	administration	NOUN
dti-1373	374	26	.	.	PUNCT
dti-1373	375	1	br	br	PROPN
dti-1373	375	2	j	j	PROPN
dti-1373	375	3	nutr	nutr	PROPN
dti-1373	375	4	.	.	PUNCT
dti-1373	376	1	2006;96	2006;96	NUM
dti-1373	376	2	:	:	PUNCT
dti-1373	376	3	62–70	62–70	NOUN
dti-1373	376	4	.	.	PUNCT
dti-1373	377	1	48	48	NUM
dti-1373	377	2	.	.	PUNCT
dti-1373	378	1	yu	yu	PROPN
dti-1373	379	1	c	c	PROPN
dti-1373	379	2	,	,	PUNCT
dti-1373	379	3	shin	shin	PROPN
dti-1373	379	4	yg	yg	PROPN
dti-1373	379	5	,	,	PUNCT
dti-1373	379	6	chow	chow	PROPN
dti-1373	379	7	a	a	PROPN
dti-1373	379	8	,	,	PUNCT
dti-1373	379	9	et	et	PROPN
dti-1373	379	10	al	al	PROPN
dti-1373	379	11	.	.	PUNCT
dti-1373	380	1	human	human	PROPN
dti-1373	380	2	,	,	PUNCT
dti-1373	380	3	rat	rat	NOUN
dti-1373	380	4	,	,	PUNCT
dti-1373	380	5	and	and	CCONJ
dti-1373	380	6	mouse	mouse	VERB
dti-1373	380	7	metabolism	metabolism	NOUN
dti-1373	380	8	of	of	ADP
dti-1373	380	9	resveratrol	resveratrol	NOUN
dti-1373	380	10	.	.	PUNCT
dti-1373	381	1	pharm	pharm	NOUN
dti-1373	381	2	res	re	NOUN
dti-1373	381	3	.	.	PUNCT
dti-1373	382	1	2002;19:1907–14	2002;19:1907–14	NUM
dti-1373	382	2	.	.	PUNCT
dti-1373	382	3	http://www.la-press.com	http://www.la-press.com	X