id	sid	tid	token	lemma	pos
dti-1375	1	1	open	open	ADJ
dti-1375	1	2	access	access	NOUN
dti-1375	1	3	full	full	ADJ
dti-1375	1	4	open	open	ADJ
dti-1375	1	5	access	access	NOUN
dti-1375	1	6	to	to	ADP
dti-1375	1	7	this	this	PRON
dti-1375	1	8	and	and	CCONJ
dti-1375	1	9	thousands	thousand	NOUN
dti-1375	1	10	of	of	ADP
dti-1375	1	11	other	other	ADJ
dti-1375	1	12	papers	paper	NOUN
dti-1375	1	13	at	at	ADP
dti-1375	1	14	http://www.la-press.com	http://www.la-press.com	X
dti-1375	1	15	.	.	PUNCT
dti-1375	2	1	drug	drug	NOUN
dti-1375	2	2	target	target	NOUN
dti-1375	2	3	insights	insight	NOUN
dti-1375	2	4	2012:6	2012:6	NUM
dti-1375	2	5	19–39	19–39	NUM
dti-1375	2	6	doi	doi	NOUN
dti-1375	2	7	:	:	PUNCT
dti-1375	2	8	10.4137	10.4137	NUM
dti-1375	2	9	/	/	SYM
dti-1375	2	10	dti.s9943	dti.s9943	NOUN
dti-1375	2	11	this	this	DET
dti-1375	2	12	article	article	NOUN
dti-1375	2	13	is	be	AUX
dti-1375	2	14	available	available	ADJ
dti-1375	2	15	from	from	ADP
dti-1375	2	16	http://www.la-press.com	http://www.la-press.com	X
dti-1375	2	17	.	.	PUNCT
dti-1375	3	1	©	©	ADP
dti-1375	3	2	the	the	DET
dti-1375	3	3	author(s	author(s	PROPN
dti-1375	3	4	)	)	PUNCT
dti-1375	3	5	,	,	PUNCT
dti-1375	3	6	publisher	publisher	NOUN
dti-1375	3	7	and	and	CCONJ
dti-1375	3	8	licensee	licensee	PROPN
dti-1375	3	9	libertas	libertas	PROPN
dti-1375	3	10	academica	academica	PROPN
dti-1375	3	11	ltd	ltd	PROPN
dti-1375	3	12	.	.	PUNCT
dti-1375	4	1	this	this	PRON
dti-1375	4	2	is	be	AUX
dti-1375	4	3	an	an	DET
dti-1375	4	4	open	open	ADJ
dti-1375	4	5	access	access	NOUN
dti-1375	4	6	article	article	NOUN
dti-1375	4	7	.	.	PUNCT
dti-1375	5	1	unrestricted	unrestricted	ADJ
dti-1375	5	2	non	non	ADJ
dti-1375	5	3	-	-	ADJ
dti-1375	5	4	commercial	commercial	ADJ
dti-1375	5	5	use	use	NOUN
dti-1375	5	6	is	be	AUX
dti-1375	5	7	permitted	permit	VERB
dti-1375	5	8	provided	provide	VERB
dti-1375	5	9	the	the	DET
dti-1375	5	10	original	original	ADJ
dti-1375	5	11	work	work	NOUN
dti-1375	5	12	is	be	AUX
dti-1375	5	13	properly	properly	ADV
dti-1375	5	14	cited	cite	VERB
dti-1375	5	15	.	.	PUNCT
dti-1375	6	1	drug	drug	NOUN
dti-1375	6	2	target	target	NOUN
dti-1375	6	3	insights	insight	NOUN
dti-1375	6	4	o	o	NOUN
dti-1375	6	5	r	r	NOUN
dti-1375	7	1	i	i	PRON
dti-1375	7	2	g	g	VERB
dti-1375	8	1	i	i	PRON
dti-1375	8	2	n	n	CCONJ
dti-1375	8	3	a	a	DET
dti-1375	8	4	l	l	NOUN
dti-1375	8	5	r	r	NOUN
dti-1375	8	6	e	e	NOUN
dti-1375	8	7	s	s	X
dti-1375	8	8	e	e	X
dti-1375	8	9	a	a	DET
dti-1375	8	10	r	r	NOUN
dti-1375	8	11	c	c	NOUN
dti-1375	8	12	h	h	NOUN
dti-1375	8	13	drug	drug	NOUN
dti-1375	8	14	target	target	NOUN
dti-1375	8	15	insights	insight	NOUN
dti-1375	8	16	2012:6	2012:6	NUM
dti-1375	8	17	19	19	NUM
dti-1375	8	18	17aag	17aag	NOUN
dti-1375	8	19	treatment	treatment	NOUN
dti-1375	8	20	accelerates	accelerate	VERB
dti-1375	8	21	doxorubicin	doxorubicin	PROPN
dti-1375	8	22	induced	induce	VERB
dti-1375	8	23	cellular	cellular	ADJ
dti-1375	8	24	senescence	senescence	NOUN
dti-1375	8	25	:	:	PUNCT
dti-1375	8	26	hsp90	hsp90	NOUN
dti-1375	8	27	interferes	interfere	VERB
dti-1375	8	28	with	with	ADP
dti-1375	8	29	enforced	enforce	VERB
dti-1375	8	30	senescence	senescence	NOUN
dti-1375	8	31	of	of	ADP
dti-1375	8	32	tumor	tumor	NOUN
dti-1375	8	33	cells	cell	NOUN
dti-1375	8	34	upasana	upasana	PROPN
dti-1375	8	35	sarangi	sarangi	PROPN
dti-1375	8	36	,	,	PUNCT
dti-1375	8	37	khande	khande	PROPN
dti-1375	8	38	rao	rao	PROPN
dti-1375	8	39	paithankar	paithankar	PROPN
dti-1375	8	40	,	,	PUNCT
dti-1375	8	41	jonnala	jonnala	PROPN
dti-1375	8	42	ujwal	ujwal	PROPN
dti-1375	8	43	kumar	kumar	PROPN
dti-1375	8	44	,	,	PUNCT
dti-1375	8	45	vaidyanathan	vaidyanathan	ADP
dti-1375	8	46	subramaniam	subramaniam	PROPN
dti-1375	8	47	and	and	CCONJ
dti-1375	8	48	amere	amere	VERB
dti-1375	8	49	subbarao	subbarao	PROPN
dti-1375	8	50	sreedhar	sreedhar	PROPN
dti-1375	8	51	csir	csir	PROPN
dti-1375	8	52	centre	centre	NOUN
dti-1375	8	53	for	for	ADP
dti-1375	8	54	cellular	cellular	ADJ
dti-1375	8	55	and	and	CCONJ
dti-1375	8	56	molecular	molecular	ADJ
dti-1375	8	57	biology	biology	NOUN
dti-1375	8	58	,	,	PUNCT
dti-1375	8	59	uppal	uppal	NOUN
dti-1375	8	60	road	road	PROPN
dti-1375	8	61	,	,	PUNCT
dti-1375	8	62	hyderabad	hyderabad	PROPN
dti-1375	8	63	500	500	NUM
dti-1375	8	64	007	007	NUM
dti-1375	8	65	,	,	PUNCT
dti-1375	8	66	andhra	andhra	PROPN
dti-1375	8	67	pradesh	pradesh	PROPN
dti-1375	8	68	,	,	PUNCT
dti-1375	8	69	india	india	PROPN
dti-1375	8	70	.	.	PUNCT
dti-1375	9	1	corresponding	correspond	VERB
dti-1375	9	2	author	author	NOUN
dti-1375	9	3	email	email	NOUN
dti-1375	9	4	:	:	PUNCT
dti-1375	9	5	assr@ccmb.res.in	assr@ccmb.res.in	PROPN
dti-1375	9	6	abstract	abstract	PROPN
dti-1375	9	7	:	:	PUNCT
dti-1375	9	8	hsp90	hsp90	PROPN
dti-1375	9	9	chaperone	chaperone	NOUN
dti-1375	9	10	has	have	AUX
dti-1375	9	11	been	be	AUX
dti-1375	9	12	identified	identify	VERB
dti-1375	9	13	as	as	ADP
dti-1375	9	14	an	an	DET
dti-1375	9	15	attractive	attractive	ADJ
dti-1375	9	16	pharmacological	pharmacological	ADJ
dti-1375	9	17	target	target	NOUN
dti-1375	9	18	to	to	ADP
dti-1375	9	19	combat	combat	NOUN
dti-1375	9	20	cancer	cancer	NOUN
dti-1375	9	21	.	.	PUNCT
dti-1375	10	1	however	however	ADV
dti-1375	10	2	,	,	PUNCT
dti-1375	10	3	some	some	DET
dti-1375	10	4	metastatic	metastatic	ADJ
dti-1375	10	5	tumors	tumor	NOUN
dti-1375	10	6	either	either	CCONJ
dti-1375	10	7	fail	fail	VERB
dti-1375	10	8	to	to	PART
dti-1375	10	9	respond	respond	VERB
dti-1375	10	10	to	to	ADP
dti-1375	10	11	hsp90	hsp90	ADJ
dti-1375	10	12	inhibition	inhibition	NOUN
dti-1375	10	13	or	or	CCONJ
dti-1375	10	14	show	show	NOUN
dti-1375	10	15	recovery	recovery	NOUN
dti-1375	10	16	necessitating	necessitate	VERB
dti-1375	10	17	irreversible	irreversible	ADJ
dti-1375	10	18	therapeutic	therapeutic	ADJ
dti-1375	10	19	strategies	strategy	NOUN
dti-1375	10	20	.	.	PUNCT
dti-1375	11	1	in	in	ADP
dti-1375	11	2	response	response	NOUN
dti-1375	11	3	to	to	ADP
dti-1375	11	4	this	this	DET
dti-1375	11	5	enforced	enforce	VERB
dti-1375	11	6	senescence	senescence	NOUN
dti-1375	11	7	has	have	AUX
dti-1375	11	8	been	be	AUX
dti-1375	11	9	proposed	propose	VERB
dti-1375	11	10	as	as	ADP
dti-1375	11	11	an	an	DET
dti-1375	11	12	alternate	alternate	ADJ
dti-1375	11	13	strategy	strategy	NOUN
dti-1375	11	14	.	.	PUNCT
dti-1375	12	1	here	here	ADV
dti-1375	12	2	,	,	PUNCT
dti-1375	12	3	we	we	PRON
dti-1375	12	4	demonstrate	demonstrate	VERB
dti-1375	12	5	that	that	SCONJ
dti-1375	12	6	inhibiting	inhibit	VERB
dti-1375	12	7	hsp90	hsp90	NOUN
dti-1375	12	8	with	with	ADP
dti-1375	12	9	17aag	17aag	NOUN
dti-1375	12	10	sensitizes	sensitize	NOUN
dti-1375	12	11	human	human	ADJ
dti-1375	12	12	neuroblastoma	neuroblastoma	NOUN
dti-1375	12	13	to	to	ADP
dti-1375	12	14	dna	dna	PROPN
dti-1375	12	15	damage	damage	NOUN
dti-1375	12	16	response	response	NOUN
dti-1375	12	17	mediated	mediate	VERB
dti-1375	12	18	cellular	cellular	ADJ
dti-1375	12	19	senescence	senescence	NOUN
dti-1375	12	20	.	.	PUNCT
dti-1375	13	1	among	among	ADP
dti-1375	13	2	individual	individual	ADJ
dti-1375	13	3	and	and	CCONJ
dti-1375	13	4	combination	combination	NOUN
dti-1375	13	5	drug	drug	NOUN
dti-1375	13	6	treatments	treatment	NOUN
dti-1375	13	7	,	,	PUNCT
dti-1375	13	8	17aag	17aag	ADJ
dti-1375	13	9	pre	pre	NOUN
dti-1375	13	10	-	-	NOUN
dti-1375	13	11	treatment	treatment	NOUN
dti-1375	13	12	followed	follow	VERB
dti-1375	13	13	by	by	ADP
dti-1375	13	14	doxorubicin	doxorubicin	PROPN
dti-1375	13	15	treatment	treatment	NOUN
dti-1375	13	16	exhibited	exhibit	VERB
dti-1375	13	17	senescence	senescence	NOUN
dti-1375	13	18	-	-	PUNCT
dti-1375	13	19	like	like	ADJ
dti-1375	13	20	characteristics	characteristic	NOUN
dti-1375	13	21	such	such	ADJ
dti-1375	13	22	as	as	ADP
dti-1375	13	23	increased	increase	VERB
dti-1375	13	24	nucleus	nucleus	NOUN
dti-1375	13	25	to	to	AUX
dti-1375	13	26	cytoplasm	cytoplasm	NOUN
dti-1375	13	27	ratio	ratio	NOUN
dti-1375	13	28	,	,	PUNCT
dti-1375	13	29	cell	cell	NOUN
dti-1375	13	30	cycle	cycle	NOUN
dti-1375	13	31	arrest	arrest	NOUN
dti-1375	13	32	,	,	PUNCT
dti-1375	13	33	sa	sa	PROPN
dti-1375	13	34	-	-	PUNCT
dti-1375	13	35	β	β	NOUN
dti-1375	13	36	-	-	ADJ
dti-1375	13	37	gal	gal	ADJ
dti-1375	13	38	staining	staining	NOUN
dti-1375	13	39	and	and	CCONJ
dti-1375	13	40	the	the	DET
dti-1375	13	41	perpetual	perpetual	ADJ
dti-1375	13	42	increase	increase	NOUN
dti-1375	13	43	in	in	ADP
dti-1375	13	44	sahf	sahf	NOUN
dti-1375	13	45	.	.	PUNCT
dti-1375	14	1	doxorubicin	doxorubicin	PROPN
dti-1375	14	2	induced	induce	VERB
dti-1375	14	3	senescence	senescence	NOUN
dti-1375	14	4	signaling	signal	VERB
dti-1375	14	5	was	be	AUX
dti-1375	14	6	mediated	mediate	VERB
dti-1375	14	7	by	by	ADP
dti-1375	14	8	p53	p53	NOUN
dti-1375	14	9	-	-	PUNCT
dti-1375	14	10	p21cip	p21cip	NOUN
dti-1375	14	11	/	/	SYM
dti-1375	14	12	waf-1	waf-1	ADV
dti-1375	14	13	and	and	CCONJ
dti-1375	14	14	was	be	AUX
dti-1375	14	15	accelerated	accelerate	VERB
dti-1375	14	16	in	in	ADP
dti-1375	14	17	the	the	DET
dti-1375	14	18	absence	absence	NOUN
dti-1375	14	19	of	of	ADP
dti-1375	14	20	functional	functional	ADJ
dti-1375	14	21	hsp90	hsp90	NOUN
dti-1375	14	22	.	.	PUNCT
dti-1375	15	1	sustained	sustain	VERB
dti-1375	15	2	p16ink4a	p16ink4a	PROPN
dti-1375	15	3	and	and	CCONJ
dti-1375	15	4	h3k4me3	h3k4me3	NOUN
dti-1375	15	5	expressions	expression	NOUN
dti-1375	15	6	correlating	correlate	VERB
dti-1375	15	7	with	with	ADP
dti-1375	15	8	unaffected	unaffected	ADJ
dti-1375	15	9	telomerase	telomerase	NOUN
dti-1375	15	10	activation	activation	NOUN
dti-1375	15	11	annulled	annul	VERB
dti-1375	15	12	replicative	replicative	ADJ
dti-1375	15	13	senescence	senescence	NOUN
dti-1375	15	14	and	and	CCONJ
dti-1375	15	15	appraised	appraise	VERB
dti-1375	15	16	stress	stress	NOUN
dti-1375	15	17	induced	induce	VERB
dti-1375	15	18	senescence	senescence	NOUN
dti-1375	15	19	.	.	PUNCT
dti-1375	16	1	despite	despite	SCONJ
dti-1375	16	2	increases	increase	NOUN
dti-1375	16	3	in	in	ADP
dti-1375	16	4	[	[	X
dti-1375	16	5	(	(	PUNCT
dti-1375	16	6	ros)i	ros)i	NOUN
dti-1375	16	7	]	]	PUNCT
dti-1375	16	8	and	and	CCONJ
dti-1375	16	9	[	[	X
dti-1375	16	10	(	(	PUNCT
dti-1375	16	11	ca2+)i	ca2+)i	PROPN
dti-1375	16	12	]	]	X
dti-1375	16	13	,	,	PUNCT
dti-1375	16	14	a	a	DET
dti-1375	16	15	concomitant	concomitant	ADJ
dti-1375	16	16	increase	increase	NOUN
dti-1375	16	17	in	in	ADP
dti-1375	16	18	cellular	cellular	ADJ
dti-1375	16	19	antioxidant	antioxidant	ADJ
dti-1375	16	20	defense	defense	NOUN
dti-1375	16	21	system	system	NOUN
dti-1375	16	22	suggested	suggest	VERB
dti-1375	16	23	oxidation	oxidation	ADJ
dti-1375	16	24	independent	independent	ADJ
dti-1375	16	25	senescence	senescence	NOUN
dti-1375	16	26	activation	activation	NOUN
dti-1375	16	27	.	.	PUNCT
dti-1375	17	1	sustained	sustained	ADJ
dti-1375	17	2	activation	activation	NOUN
dti-1375	17	3	of	of	ADP
dti-1375	17	4	survival	survival	NOUN
dti-1375	17	5	(	(	PUNCT
dti-1375	17	6	akt	akt	PROPN
dti-1375	17	7	)	)	PUNCT
dti-1375	17	8	and	and	CCONJ
dti-1375	17	9	proliferative	proliferative	ADJ
dti-1375	17	10	(	(	PUNCT
dti-1375	17	11	erk1/2	erk1/2	PROPN
dti-1375	17	12	)	)	PUNCT
dti-1375	17	13	kinases	kinase	NOUN
dti-1375	17	14	fosters	foster	VERB
dti-1375	17	15	robustness	robustness	NOUN
dti-1375	17	16	of	of	ADP
dti-1375	17	17	cells	cell	NOUN
dti-1375	17	18	.	.	PUNCT
dti-1375	18	1	invigorating	invigorate	VERB
dti-1375	18	2	senescent	senescent	ADJ
dti-1375	18	3	cells	cell	NOUN
dti-1375	18	4	with	with	ADP
dti-1375	18	5	growth	growth	NOUN
dti-1375	18	6	factor	factor	NOUN
dti-1375	18	7	or	or	CCONJ
dti-1375	18	8	snooping	snoop	VERB
dti-1375	18	9	with	with	ADP
dti-1375	18	10	mtor	mtor	NOUN
dti-1375	18	11	or	or	CCONJ
dti-1375	18	12	pi3	pi3	NOUN
dti-1375	18	13	kinase	kinase	NOUN
dti-1375	18	14	inhibitors	inhibitor	NOUN
dti-1375	18	15	compromised	compromise	VERB
dti-1375	18	16	cell	cell	NOUN
dti-1375	18	17	survival	survival	NOUN
dti-1375	18	18	but	but	CCONJ
dti-1375	18	19	not	not	PART
dti-1375	18	20	senescence	senescence	NOUN
dti-1375	18	21	.	.	PUNCT
dti-1375	19	1	intriguingly	intriguingly	ADV
dti-1375	19	2	,	,	PUNCT
dti-1375	19	3	senescence	senescence	NOUN
dti-1375	19	4	-	-	PUNCT
dti-1375	19	5	associated	associate	VERB
dti-1375	19	6	secretory	secretory	ADJ
dti-1375	19	7	factors	factor	NOUN
dti-1375	19	8	from	from	ADP
dti-1375	19	9	the	the	DET
dti-1375	19	10	senescence	senescence	NOUN
dti-1375	19	11	cells	cell	NOUN
dti-1375	19	12	manifested	manifest	VERB
dti-1375	19	13	established	establish	VERB
dti-1375	19	14	senescence	senescence	NOUN
dti-1375	19	15	in	in	ADP
dti-1375	19	16	neuroblastoma	neuroblastoma	NOUN
dti-1375	19	17	,	,	PUNCT
dti-1375	19	18	which	which	PRON
dti-1375	19	19	offers	offer	VERB
dti-1375	19	20	clinical	clinical	ADJ
dti-1375	19	21	advantage	advantage	NOUN
dti-1375	19	22	to	to	ADP
dti-1375	19	23	our	our	PRON
dti-1375	19	24	approach	approach	NOUN
dti-1375	19	25	.	.	PUNCT
dti-1375	20	1	our	our	PRON
dti-1375	20	2	study	study	NOUN
dti-1375	20	3	discusses	discuss	VERB
dti-1375	20	4	tumor	tumor	NOUN
dti-1375	20	5	selective	selective	ADJ
dti-1375	20	6	functions	function	NOUN
dti-1375	20	7	of	of	ADP
dti-1375	20	8	hsp90	hsp90	NOUN
dti-1375	20	9	and	and	CCONJ
dti-1375	20	10	discusses	discuss	VERB
dti-1375	20	11	irrefutable	irrefutable	ADJ
dti-1375	20	12	strategies	strategy	NOUN
dti-1375	20	13	of	of	ADP
dti-1375	20	14	hsp90	hsp90	ADJ
dti-1375	20	15	inhibition	inhibition	NOUN
dti-1375	20	16	in	in	ADP
dti-1375	20	17	anticancer	anticancer	NOUN
dti-1375	20	18	treatments	treatment	NOUN
dti-1375	20	19	.	.	PUNCT
dti-1375	21	1	keywords	keyword	NOUN
dti-1375	21	2	:	:	PUNCT
dti-1375	21	3	hsp90	hsp90	NOUN
dti-1375	21	4	,	,	PUNCT
dti-1375	21	5	senescence	senescence	NOUN
dti-1375	21	6	,	,	PUNCT
dti-1375	21	7	neuroblastoma	neuroblastoma	ADJ
dti-1375	21	8	,	,	PUNCT
dti-1375	21	9	17aag	17aag	NOUN
dti-1375	21	10	,	,	PUNCT
dti-1375	21	11	doxorubicin	doxorubicin	PROPN
dti-1375	21	12	http://www.la-press.com	http://www.la-press.com	X
dti-1375	21	13	http://dx.doi.org/10.4137/dti.s9943	http://dx.doi.org/10.4137/dti.s9943	X
dti-1375	21	14	http://www.la-press.com	http://www.la-press.com	X
dti-1375	21	15	http://www.la-press.com/drug-target-insights-journal-j23	http://www.la-press.com/drug-target-insights-journal-j23	PROPN
dti-1375	21	16	http://www.la-press.com	http://www.la-press.com	X
dti-1375	22	1	mailto:upasana@ccmb.res.in	mailto:upasana@ccmb.res.in	NOUN
dti-1375	22	2	sarangi	sarangi	PROPN
dti-1375	22	3	et	et	PROPN
dti-1375	22	4	al	al	PROPN
dti-1375	22	5	20	20	NUM
dti-1375	22	6	drug	drug	NOUN
dti-1375	22	7	target	target	NOUN
dti-1375	22	8	insights	insight	NOUN
dti-1375	22	9	2012:6	2012:6	NUM
dti-1375	22	10	introduction	introduction	NOUN
dti-1375	22	11	heat	heat	NOUN
dti-1375	22	12	shock	shock	NOUN
dti-1375	22	13	proteins	protein	NOUN
dti-1375	22	14	(	(	PUNCT
dti-1375	22	15	hsps	hsps	PROPN
dti-1375	22	16	)	)	PUNCT
dti-1375	22	17	are	be	AUX
dti-1375	22	18	implicated	implicate	VERB
dti-1375	22	19	in	in	ADP
dti-1375	22	20	evading	evade	VERB
dti-1375	22	21	stress	stress	NOUN
dti-1375	22	22	induced	induce	VERB
dti-1375	22	23	cell	cell	NOUN
dti-1375	22	24	death	death	NOUN
dti-1375	22	25	programming	programming	NOUN
dti-1375	22	26	and	and	CCONJ
dti-1375	22	27	in	in	ADP
dti-1375	22	28	adaptive	adaptive	ADJ
dti-1375	22	29	cellular	cellular	ADJ
dti-1375	22	30	responses	response	NOUN
dti-1375	22	31	to	to	ADP
dti-1375	22	32	stress.1	stress.1	ADP
dti-1375	22	33	the	the	DET
dti-1375	22	34	hsp90	hsp90	PROPN
dti-1375	22	35	chaperone	chaperone	NOUN
dti-1375	22	36	functions	function	NOUN
dti-1375	22	37	are	be	AUX
dti-1375	22	38	entangled	entangle	VERB
dti-1375	22	39	with	with	ADP
dti-1375	22	40	tumor	tumor	NOUN
dti-1375	22	41	progression	progression	NOUN
dti-1375	22	42	identifying	identify	VERB
dti-1375	22	43	this	this	DET
dti-1375	22	44	protein	protein	NOUN
dti-1375	22	45	as	as	ADP
dti-1375	22	46	a	a	DET
dti-1375	22	47	cancer	cancer	NOUN
dti-1375	22	48	chaperone.2	chaperone.2	NOUN
dti-1375	22	49	in	in	ADP
dti-1375	22	50	support	support	NOUN
dti-1375	22	51	of	of	ADP
dti-1375	22	52	this	this	PRON
dti-1375	22	53	,	,	PUNCT
dti-1375	22	54	the	the	DET
dti-1375	22	55	surface	surface	NOUN
dti-1375	22	56	expression	expression	NOUN
dti-1375	22	57	of	of	ADP
dti-1375	22	58	hsp90	hsp90	PROPN
dti-1375	22	59	in	in	ADP
dti-1375	22	60	cancers	cancer	NOUN
dti-1375	22	61	of	of	ADP
dti-1375	22	62	the	the	DET
dti-1375	22	63	human	human	ADJ
dti-1375	22	64	nervous	nervous	ADJ
dti-1375	22	65	system	system	NOUN
dti-1375	22	66	(	(	PUNCT
dti-1375	22	67	nb69	nb69	PROPN
dti-1375	22	68	,	,	PUNCT
dti-1375	22	69	shsy5y	shsy5y	NOUN
dti-1375	22	70	,	,	PUNCT
dti-1375	22	71	sk	sk	NOUN
dti-1375	22	72	-	-	PUNCT
dti-1375	22	73	n	n	CCONJ
dti-1375	22	74	-	-	PUNCT
dti-1375	22	75	sh	sh	NOUN
dti-1375	22	76	)	)	PUNCT
dti-1375	22	77	correlated	correlate	VERB
dti-1375	22	78	with	with	ADP
dti-1375	22	79	enhanced	enhanced	ADJ
dti-1375	22	80	survival	survival	NOUN
dti-1375	22	81	and	and	CCONJ
dti-1375	22	82	proliferation	proliferation	NOUN
dti-1375	22	83	,	,	PUNCT
dti-1375	22	84	whose	whose	DET
dti-1375	22	85	functional	functional	ADJ
dti-1375	22	86	blockade	blockade	NOUN
dti-1375	22	87	with	with	ADP
dti-1375	22	88	17	17	NUM
dti-1375	22	89	allylamino-17	allylamino-17	NOUN
dti-1375	22	90	-	-	PUNCT
dti-1375	22	91	demethoxygeldanamycin	demethoxygeldanamycin	PROPN
dti-1375	22	92	(	(	PUNCT
dti-1375	22	93	17aag	17aag	NOUN
dti-1375	22	94	)	)	PUNCT
dti-1375	22	95	or	or	CCONJ
dti-1375	22	96	geldanamycin	geldanamycin	NOUN
dti-1375	22	97	compromised	compromise	VERB
dti-1375	22	98	cell	cell	NOUN
dti-1375	22	99	survival.3–5	survival.3–5	NOUN
dti-1375	22	100	as	as	ADP
dti-1375	22	101	an	an	DET
dti-1375	22	102	exception	exception	NOUN
dti-1375	22	103	,	,	PUNCT
dti-1375	22	104	the	the	DET
dti-1375	22	105	drug	drug	NOUN
dti-1375	22	106	resistant	resistant	ADJ
dti-1375	22	107	and	and	CCONJ
dti-1375	22	108	metastatic	metastatic	ADJ
dti-1375	22	109	human	human	ADJ
dti-1375	22	110	neuroblastoma	neuroblastoma	NOUN
dti-1375	22	111	,	,	PUNCT
dti-1375	22	112	imr-32	imr-32	CCONJ
dti-1375	22	113	failed	fail	VERB
dti-1375	22	114	to	to	PART
dti-1375	22	115	respond	respond	VERB
dti-1375	22	116	to	to	ADP
dti-1375	22	117	17aag	17aag	NOUN
dti-1375	22	118	treatment6	treatment6	PROPN
dti-1375	22	119	despite	despite	SCONJ
dti-1375	22	120	hsp90	hsp90	PROPN
dti-1375	22	121	being	be	AUX
dti-1375	22	122	the	the	DET
dti-1375	22	123	central	central	ADJ
dti-1375	22	124	regulator	regulator	NOUN
dti-1375	22	125	of	of	ADP
dti-1375	22	126	cell	cell	NOUN
dti-1375	22	127	signaling.7,8	signaling.7,8	PROPN
dti-1375	22	128	the	the	DET
dti-1375	22	129	non	non	NOUN
dti-1375	22	130	-	-	ADJ
dti-1375	22	131	responsiveness	responsiveness	NOUN
dti-1375	22	132	may	may	AUX
dti-1375	22	133	relate	relate	VERB
dti-1375	22	134	to	to	ADP
dti-1375	22	135	major	major	ADJ
dti-1375	22	136	regulatory	regulatory	ADJ
dti-1375	22	137	mechanisms	mechanism	NOUN
dti-1375	22	138	such	such	ADJ
dti-1375	22	139	as	as	ADP
dti-1375	22	140	tumor	tumor	NOUN
dti-1375	22	141	suppression	suppression	NOUN
dti-1375	22	142	.	.	PUNCT
dti-1375	23	1	in	in	ADP
dti-1375	23	2	addition	addition	NOUN
dti-1375	23	3	to	to	ADP
dti-1375	23	4	essential	essential	ADJ
dti-1375	23	5	oncogenic	oncogenic	ADJ
dti-1375	23	6	kinase	kinase	NOUN
dti-1375	23	7	activation	activation	NOUN
dti-1375	23	8	,	,	PUNCT
dti-1375	23	9	inactivation	inactivation	NOUN
dti-1375	23	10	of	of	ADP
dti-1375	23	11	tumor	tumor	NOUN
dti-1375	23	12	suppressor	suppressor	NOUN
dti-1375	23	13	mechanisms	mechanism	NOUN
dti-1375	23	14	involving	involve	VERB
dti-1375	23	15	p53	p53	NOUN
dti-1375	23	16	-	-	PUNCT
dti-1375	23	17	p21cip	p21cip	NOUN
dti-1375	23	18	/	/	SYM
dti-1375	23	19	waf-1	waf-1	ADV
dti-1375	23	20	and	and	CCONJ
dti-1375	23	21	prb	prb	ADV
dti-1375	23	22	-	-	PUNCT
dti-1375	23	23	p16ink4a	p16ink4a	NOUN
dti-1375	23	24	are	be	AUX
dti-1375	23	25	significantly	significantly	ADV
dti-1375	23	26	implicated	implicate	VERB
dti-1375	23	27	in	in	ADP
dti-1375	23	28	cancer	cancer	NOUN
dti-1375	23	29	progression	progression	NOUN
dti-1375	23	30	.	.	PUNCT
dti-1375	24	1	despite	despite	SCONJ
dti-1375	24	2	occurrence	occurrence	NOUN
dti-1375	24	3	of	of	ADP
dti-1375	24	4	mutations	mutation	NOUN
dti-1375	24	5	in	in	ADP
dti-1375	24	6	p53	p53	NOUN
dti-1375	24	7	tumor	tumor	NOUN
dti-1375	24	8	suppressor	suppressor	NOUN
dti-1375	24	9	gene	gene	NOUN
dti-1375	24	10	in	in	ADP
dti-1375	24	11	a	a	DET
dti-1375	24	12	large	large	ADJ
dti-1375	24	13	number	number	NOUN
dti-1375	24	14	of	of	ADP
dti-1375	24	15	human	human	ADJ
dti-1375	24	16	tumors	tumor	NOUN
dti-1375	24	17	,	,	PUNCT
dti-1375	24	18	neuroblastoma	neuroblastoma	NOUN
dti-1375	24	19	retains	retain	VERB
dti-1375	24	20	functional	functional	ADJ
dti-1375	24	21	protein	protein	NOUN
dti-1375	24	22	,	,	PUNCT
dti-1375	24	23	and	and	CCONJ
dti-1375	24	24	this	this	PRON
dti-1375	24	25	could	could	AUX
dti-1375	24	26	be	be	AUX
dti-1375	24	27	the	the	DET
dti-1375	24	28	reason	reason	NOUN
dti-1375	24	29	why	why	SCONJ
dti-1375	24	30	inactivating	inactivate	VERB
dti-1375	24	31	mutations	mutation	NOUN
dti-1375	24	32	in	in	ADP
dti-1375	24	33	p53	p53	NOUN
dti-1375	24	34	enhances	enhance	NOUN
dti-1375	24	35	chemotherapy	chemotherapy	NOUN
dti-1375	24	36	induced	induce	VERB
dti-1375	24	37	cytotoxicity.9	cytotoxicity.9	NOUN
dti-1375	24	38	the	the	DET
dti-1375	24	39	neuroblastoma	neuroblastoma	NOUN
dti-1375	24	40	also	also	ADV
dti-1375	24	41	comprise	comprise	VERB
dti-1375	24	42	constitutive	constitutive	ADJ
dti-1375	24	43	p16ink4a	p16ink4a	NOUN
dti-1375	24	44	expression	expression	NOUN
dti-1375	24	45	independent	independent	ADJ
dti-1375	24	46	of	of	ADP
dti-1375	24	47	rb	rb	NOUN
dti-1375	24	48	phosphorylation.10	phosphorylation.10	VERB
dti-1375	24	49	the	the	DET
dti-1375	24	50	constitutive	constitutive	ADJ
dti-1375	24	51	p16ink4a	p16ink4a	NOUN
dti-1375	24	52	expression	expression	NOUN
dti-1375	24	53	was	be	AUX
dti-1375	24	54	presumed	presume	VERB
dti-1375	24	55	to	to	PART
dti-1375	24	56	act	act	VERB
dti-1375	24	57	against	against	ADP
dti-1375	24	58	not	not	PART
dti-1375	24	59	only	only	ADV
dti-1375	24	60	cytotoxic	cytotoxic	ADJ
dti-1375	24	61	pathways	pathway	NOUN
dti-1375	24	62	but	but	CCONJ
dti-1375	24	63	to	to	PART
dti-1375	24	64	bypass	bypass	VERB
dti-1375	24	65	senescence	senescence	NOUN
dti-1375	24	66	programming	programming	NOUN
dti-1375	24	67	.	.	PUNCT
dti-1375	25	1	to	to	PART
dti-1375	25	2	circumvent	circumvent	VERB
dti-1375	25	3	chemotherapeutics	chemotherapeutic	NOUN
dti-1375	25	4	induced	induce	VERB
dti-1375	25	5	non	non	ADJ
dti-1375	25	6	-	-	ADJ
dti-1375	25	7	selective	selective	ADJ
dti-1375	25	8	cytotoxicity	cytotoxicity	NOUN
dti-1375	25	9	and	and	CCONJ
dti-1375	25	10	to	to	PART
dti-1375	25	11	promote	promote	VERB
dti-1375	25	12	the	the	DET
dti-1375	25	13	therapeutic	therapeutic	ADJ
dti-1375	25	14	potential	potential	NOUN
dti-1375	25	15	of	of	ADP
dti-1375	25	16	pharmacological	pharmacological	ADJ
dti-1375	25	17	inhibitors	inhibitor	NOUN
dti-1375	25	18	of	of	ADP
dti-1375	25	19	hsp90	hsp90	NOUN
dti-1375	25	20	in	in	ADP
dti-1375	25	21	metastatic	metastatic	ADJ
dti-1375	25	22	tumors	tumor	NOUN
dti-1375	25	23	,	,	PUNCT
dti-1375	25	24	several	several	ADJ
dti-1375	25	25	combination	combination	NOUN
dti-1375	25	26	drug	drug	NOUN
dti-1375	25	27	treatment	treatment	NOUN
dti-1375	25	28	strategies	strategy	NOUN
dti-1375	25	29	have	have	AUX
dti-1375	25	30	been	be	AUX
dti-1375	25	31	proposed.6–8	proposed.6–8	ADJ
dti-1375	25	32	these	these	DET
dti-1375	25	33	combination	combination	NOUN
dti-1375	25	34	treatments	treatment	NOUN
dti-1375	25	35	,	,	PUNCT
dti-1375	25	36	however	however	ADV
dti-1375	25	37	,	,	PUNCT
dti-1375	25	38	suffer	suffer	VERB
dti-1375	25	39	due	due	ADP
dti-1375	25	40	to	to	ADP
dti-1375	25	41	induced	induce	VERB
dti-1375	25	42	stress	stress	NOUN
dti-1375	25	43	response	response	NOUN
dti-1375	25	44	mechanism	mechanism	NOUN
dti-1375	25	45	,	,	PUNCT
dti-1375	25	46	which	which	PRON
dti-1375	25	47	may	may	AUX
dti-1375	25	48	help	help	VERB
dti-1375	25	49	in	in	ADP
dti-1375	25	50	cell	cell	NOUN
dti-1375	25	51	recovery	recovery	NOUN
dti-1375	25	52	and	and	CCONJ
dti-1375	25	53	in	in	ADP
dti-1375	25	54	making	make	VERB
dti-1375	25	55	aggressive	aggressive	ADJ
dti-1375	25	56	cancer	cancer	NOUN
dti-1375	25	57	phenotypes	phenotype	NOUN
dti-1375	25	58	or	or	CCONJ
dti-1375	25	59	affect	affect	VERB
dti-1375	25	60	bystander	bystander	NOUN
dti-1375	25	61	cells	cell	NOUN
dti-1375	25	62	due	due	ADJ
dti-1375	25	63	to	to	ADP
dti-1375	25	64	lack	lack	NOUN
dti-1375	25	65	of	of	ADP
dti-1375	25	66	tumor	tumor	NOUN
dti-1375	25	67	selectivity	selectivity	NOUN
dti-1375	25	68	.	.	PUNCT
dti-1375	26	1	the	the	DET
dti-1375	26	2	dna	dna	PROPN
dti-1375	26	3	topoisomerase	topoisomerase	NOUN
dti-1375	26	4	i	i	PRON
dti-1375	26	5	inhibitor	inhibitor	NOUN
dti-1375	26	6	,	,	PUNCT
dti-1375	26	7	doxorubicin	doxorubicin	PROPN
dti-1375	26	8	has	have	AUX
dti-1375	26	9	been	be	AUX
dti-1375	26	10	shown	show	VERB
dti-1375	26	11	to	to	PART
dti-1375	26	12	induce	induce	VERB
dti-1375	26	13	senescence	senescence	NOUN
dti-1375	26	14	-	-	PUNCT
dti-1375	26	15	like	like	ADJ
dti-1375	26	16	phenotype	phenotype	NOUN
dti-1375	26	17	in	in	ADP
dti-1375	26	18	cells	cell	NOUN
dti-1375	26	19	exposed	expose	VERB
dti-1375	26	20	to	to	ADP
dti-1375	26	21	prolonged	prolonged	ADJ
dti-1375	26	22	treatments	treatment	NOUN
dti-1375	26	23	.	.	PUNCT
dti-1375	27	1	subsequent	subsequent	ADJ
dti-1375	27	2	to	to	ADP
dti-1375	27	3	these	these	DET
dti-1375	27	4	findings	finding	NOUN
dti-1375	27	5	,	,	PUNCT
dti-1375	27	6	doxorubicin	doxorubicin	PROPN
dti-1375	27	7	combination	combination	NOUN
dti-1375	27	8	with	with	ADP
dti-1375	27	9	akt	akt	PROPN
dti-1375	27	10	targeting	target	VERB
dti-1375	27	11	was	be	AUX
dti-1375	27	12	shown	show	VERB
dti-1375	27	13	to	to	PART
dti-1375	27	14	be	be	AUX
dti-1375	27	15	effective	effective	ADJ
dti-1375	27	16	in	in	ADP
dti-1375	27	17	akt	akt	PROPN
dti-1375	27	18	positive	positive	ADJ
dti-1375	27	19	cells	cell	NOUN
dti-1375	27	20	for	for	ADP
dti-1375	27	21	cancer	cancer	NOUN
dti-1375	27	22	treatment.11	treatment.11	NOUN
dti-1375	27	23	nevertheless	nevertheless	ADV
dti-1375	27	24	,	,	PUNCT
dti-1375	27	25	neuroblastoma	neuroblastoma	NOUN
dti-1375	27	26	cells	cell	NOUN
dti-1375	27	27	possess	possess	VERB
dti-1375	27	28	altered	alter	VERB
dti-1375	27	29	pi3k	pi3k	PROPN
dti-1375	27	30	-	-	PUNCT
dti-1375	27	31	akt	akt	PROPN
dti-1375	27	32	-	-	PUNCT
dti-1375	27	33	mtor	mtor	PROPN
dti-1375	27	34	pathway	pathway	NOUN
dti-1375	27	35	activation	activation	NOUN
dti-1375	27	36	that	that	PRON
dti-1375	27	37	correlates	correlate	VERB
dti-1375	27	38	with	with	ADP
dti-1375	27	39	poor	poor	ADJ
dti-1375	27	40	prognosis12	prognosis12	NOUN
dti-1375	27	41	and	and	CCONJ
dti-1375	27	42	do	do	AUX
dti-1375	27	43	not	not	PART
dti-1375	27	44	respond	respond	VERB
dti-1375	27	45	to	to	ADP
dti-1375	27	46	akt	akt	PROPN
dti-1375	27	47	destabilization	destabilization	NOUN
dti-1375	27	48	even	even	ADV
dti-1375	27	49	with	with	ADP
dti-1375	27	50	17aag	17aag	NOUN
dti-1375	27	51	induced	induce	VERB
dti-1375	27	52	disassociation	disassociation	NOUN
dti-1375	27	53	of	of	ADP
dti-1375	27	54	akt	akt	PROPN
dti-1375	27	55	from	from	ADP
dti-1375	27	56	hsp90	hsp90	PROPN
dti-1375	27	57	binding.6	binding.6	VERB
dti-1375	27	58	considering	consider	VERB
dti-1375	27	59	the	the	DET
dti-1375	27	60	constraints	constraint	NOUN
dti-1375	27	61	associated	associate	VERB
dti-1375	27	62	with	with	ADP
dti-1375	27	63	17aag	17aag	ADJ
dti-1375	27	64	response	response	NOUN
dti-1375	27	65	in	in	ADP
dti-1375	27	66	imr-32	imr-32	ADV
dti-1375	27	67	neuroblastoma	neuroblastoma	NOUN
dti-1375	27	68	,	,	PUNCT
dti-1375	27	69	we	we	PRON
dti-1375	27	70	hypothesized	hypothesize	VERB
dti-1375	27	71	that	that	DET
dti-1375	27	72	functional	functional	ADJ
dti-1375	27	73	bereavement	bereavement	NOUN
dti-1375	27	74	of	of	ADP
dti-1375	27	75	hsp90	hsp90	ADJ
dti-1375	27	76	status	status	NOUN
dti-1375	27	77	combining	combine	VERB
dti-1375	27	78	with	with	ADP
dti-1375	27	79	doxorubicin	doxorubicin	PROPN
dti-1375	27	80	may	may	AUX
dti-1375	27	81	effectively	effectively	ADV
dti-1375	27	82	combat	combat	VERB
dti-1375	27	83	cancer	cancer	NOUN
dti-1375	27	84	.	.	PUNCT
dti-1375	28	1	in	in	ADP
dti-1375	28	2	the	the	DET
dti-1375	28	3	present	present	ADJ
dti-1375	28	4	study	study	NOUN
dti-1375	28	5	,	,	PUNCT
dti-1375	28	6	we	we	PRON
dti-1375	28	7	investigated	investigate	VERB
dti-1375	28	8	the	the	DET
dti-1375	28	9	acceleration	acceleration	NOUN
dti-1375	28	10	of	of	ADP
dti-1375	28	11	pre	pre	ADJ
dti-1375	28	12	-	-	ADJ
dti-1375	28	13	sensitizing	sensitizing	ADJ
dti-1375	28	14	effects	effect	NOUN
dti-1375	28	15	of	of	ADP
dti-1375	28	16	hsp90	hsp90	ADJ
dti-1375	28	17	inhibition	inhibition	NOUN
dti-1375	28	18	on	on	ADP
dti-1375	28	19	doxorubicin	doxorubicin	PROPN
dti-1375	28	20	induced	induce	VERB
dti-1375	28	21	cellular	cellular	ADJ
dti-1375	28	22	senescence	senescence	NOUN
dti-1375	28	23	.	.	PUNCT
dti-1375	29	1	the	the	DET
dti-1375	29	2	acquired	acquire	VERB
dti-1375	29	3	senescence	senescence	NOUN
dti-1375	29	4	phenotype	phenotype	NOUN
dti-1375	29	5	was	be	AUX
dti-1375	29	6	characterized	characterize	VERB
dti-1375	29	7	by	by	ADP
dti-1375	29	8	increased	increase	VERB
dti-1375	29	9	senescence	senescence	NOUN
dti-1375	29	10	associated	associate	VERB
dti-1375	29	11	β	β	NOUN
dti-1375	29	12	-	-	NOUN
dti-1375	29	13	galactosidase	galactosidase	ADJ
dti-1375	29	14	(	(	PUNCT
dti-1375	29	15	sa	sa	NOUN
dti-1375	29	16	-	-	PUNCT
dti-1375	29	17	β	β	NOUN
dti-1375	29	18	-	-	ADJ
dti-1375	29	19	gal	gal	ADJ
dti-1375	29	20	)	)	PUNCT
dti-1375	29	21	activity	activity	NOUN
dti-1375	29	22	and	and	CCONJ
dti-1375	29	23	senescence	senescence	NOUN
dti-1375	29	24	associated	associate	VERB
dti-1375	29	25	heterochromatin	heterochromatin	NOUN
dti-1375	29	26	foci	focus	NOUN
dti-1375	29	27	(	(	PUNCT
dti-1375	29	28	sahf	sahf	NOUN
dti-1375	29	29	)	)	PUNCT
dti-1375	29	30	.	.	PUNCT
dti-1375	30	1	senescence	senescence	NOUN
dti-1375	30	2	obtained	obtain	VERB
dti-1375	30	3	was	be	AUX
dti-1375	30	4	neither	neither	CCONJ
dti-1375	30	5	associated	associate	VERB
dti-1375	30	6	with	with	ADP
dti-1375	30	7	oxidative	oxidative	ADJ
dti-1375	30	8	damage	damage	NOUN
dti-1375	30	9	nor	nor	CCONJ
dti-1375	30	10	involving	involve	VERB
dti-1375	30	11	telomere	telomere	NOUN
dti-1375	30	12	shortening	shortening	NOUN
dti-1375	30	13	.	.	PUNCT
dti-1375	31	1	biochemical	biochemical	ADJ
dti-1375	31	2	analyses	analysis	NOUN
dti-1375	31	3	suggested	suggest	VERB
dti-1375	31	4	involvement	involvement	NOUN
dti-1375	31	5	of	of	ADP
dti-1375	31	6	p53	p53	NOUN
dti-1375	31	7	-	-	PUNCT
dti-1375	31	8	p21cip	p21cip	NOUN
dti-1375	31	9	/	/	SYM
dti-1375	31	10	waf-1	waf-1	ADJ
dti-1375	31	11	pathways	pathway	NOUN
dti-1375	31	12	in	in	ADP
dti-1375	31	13	senescence	senescence	NOUN
dti-1375	31	14	activation	activation	NOUN
dti-1375	31	15	,	,	PUNCT
dti-1375	31	16	which	which	PRON
dti-1375	31	17	is	be	AUX
dti-1375	31	18	independent	independent	ADJ
dti-1375	31	19	of	of	ADP
dti-1375	31	20	prb	prb	NOUN
dti-1375	31	21	-	-	PUNCT
dti-1375	31	22	p16ink4a	p16ink4a	NOUN
dti-1375	31	23	pathway	pathway	NOUN
dti-1375	31	24	.	.	PUNCT
dti-1375	32	1	further	far	ADV
dti-1375	32	2	,	,	PUNCT
dti-1375	32	3	the	the	DET
dti-1375	32	4	senescence	senescence	NOUN
dti-1375	32	5	phenotype	phenotype	NOUN
dti-1375	32	6	was	be	AUX
dti-1375	32	7	resistant	resistant	ADJ
dti-1375	32	8	to	to	ADP
dti-1375	32	9	growth	growth	NOUN
dti-1375	32	10	stimulus	stimulus	NOUN
dti-1375	32	11	and	and	CCONJ
dti-1375	32	12	exhibited	exhibit	VERB
dti-1375	32	13	multidrug	multidrug	NOUN
dti-1375	32	14	resistance	resistance	NOUN
dti-1375	32	15	.	.	PUNCT
dti-1375	33	1	the	the	DET
dti-1375	33	2	secretory	secretory	ADJ
dti-1375	33	3	factors	factor	NOUN
dti-1375	33	4	present	present	ADJ
dti-1375	33	5	in	in	ADP
dti-1375	33	6	the	the	DET
dti-1375	33	7	conditioned	condition	VERB
dti-1375	33	8	medium	medium	NOUN
dti-1375	33	9	can	can	AUX
dti-1375	33	10	activate	activate	VERB
dti-1375	33	11	senescence	senescence	NOUN
dti-1375	33	12	-	-	PUNCT
dti-1375	33	13	like	like	ADJ
dti-1375	33	14	phenotype	phenotype	NOUN
dti-1375	33	15	in	in	ADP
dti-1375	33	16	other	other	ADJ
dti-1375	33	17	human	human	ADJ
dti-1375	33	18	tumor	tumor	NOUN
dti-1375	33	19	cells	cell	NOUN
dti-1375	33	20	.	.	PUNCT
dti-1375	34	1	our	our	PRON
dti-1375	34	2	findings	finding	NOUN
dti-1375	34	3	suggest	suggest	VERB
dti-1375	34	4	that	that	SCONJ
dti-1375	34	5	hsp90	hsp90	ADJ
dti-1375	34	6	acts	act	NOUN
dti-1375	34	7	as	as	ADP
dti-1375	34	8	a	a	DET
dti-1375	34	9	barrier	barrier	NOUN
dti-1375	34	10	to	to	ADP
dti-1375	34	11	enforced	enforce	VERB
dti-1375	34	12	senescence	senescence	NOUN
dti-1375	34	13	response	response	NOUN
dti-1375	34	14	in	in	ADP
dti-1375	34	15	tumor	tumor	NOUN
dti-1375	34	16	cells	cell	NOUN
dti-1375	34	17	.	.	PUNCT
dti-1375	35	1	materials	material	NOUN
dti-1375	35	2	and	and	CCONJ
dti-1375	35	3	methods	method	NOUN
dti-1375	35	4	cell	cell	NOUN
dti-1375	35	5	cultures	culture	NOUN
dti-1375	35	6	,	,	PUNCT
dti-1375	35	7	treatments	treatment	NOUN
dti-1375	35	8	and	and	CCONJ
dti-1375	35	9	reagents	reagent	NOUN
dti-1375	35	10	imr-32	imr-32	NOUN
dti-1375	35	11	,	,	PUNCT
dti-1375	35	12	sra01	sra01	NOUN
dti-1375	35	13	,	,	PUNCT
dti-1375	35	14	and	and	CCONJ
dti-1375	35	15	jurkat	jurkat	PROPN
dti-1375	35	16	cells	cell	NOUN
dti-1375	35	17	were	be	AUX
dti-1375	35	18	from	from	ADP
dti-1375	35	19	american	american	ADJ
dti-1375	35	20	type	type	NOUN
dti-1375	35	21	cell	cell	NOUN
dti-1375	35	22	culture	culture	NOUN
dti-1375	35	23	.	.	PUNCT
dti-1375	36	1	cells	cell	NOUN
dti-1375	36	2	were	be	AUX
dti-1375	36	3	grown	grow	VERB
dti-1375	36	4	and	and	CCONJ
dti-1375	36	5	maintained	maintain	VERB
dti-1375	36	6	in	in	ADP
dti-1375	36	7	dmem	dmem	NOUN
dti-1375	36	8	containing	contain	VERB
dti-1375	36	9	10	10	NUM
dti-1375	36	10	%	%	NOUN
dti-1375	36	11	fetal	fetal	ADJ
dti-1375	36	12	bovine	bovine	NOUN
dti-1375	36	13	serum	serum	NOUN
dti-1375	36	14	albumin	albumin	NOUN
dti-1375	36	15	in	in	ADP
dti-1375	36	16	the	the	DET
dti-1375	36	17	presence	presence	NOUN
dti-1375	36	18	of	of	ADP
dti-1375	36	19	penicillin	penicillin	NOUN
dti-1375	36	20	(	(	PUNCT
dti-1375	36	21	100	100	NUM
dti-1375	36	22	u	u	NOUN
dti-1375	36	23	/	/	SYM
dti-1375	36	24	ml	ml	NOUN
dti-1375	36	25	)	)	PUNCT
dti-1375	36	26	,	,	PUNCT
dti-1375	36	27	streptomycin	streptomycin	PROPN
dti-1375	36	28	(	(	PUNCT
dti-1375	36	29	50	50	NUM
dti-1375	36	30	µg	µg	NOUN
dti-1375	36	31	/	/	SYM
dti-1375	36	32	ml	ml	NOUN
dti-1375	36	33	)	)	PUNCT
dti-1375	36	34	and	and	CCONJ
dti-1375	36	35	kanamycin	kanamycin	PROPN
dti-1375	36	36	(	(	PUNCT
dti-1375	36	37	30	30	NUM
dti-1375	36	38	µg	µg	NOUN
dti-1375	36	39	/	/	SYM
dti-1375	36	40	ml	ml	NOUN
dti-1375	36	41	)	)	PUNCT
dti-1375	36	42	at	at	ADP
dti-1375	36	43	37	37	NUM
dti-1375	36	44	°	°	SYM
dti-1375	36	45	c	c	NOUN
dti-1375	36	46	in	in	ADP
dti-1375	36	47	a	a	DET
dti-1375	36	48	humidified	humidified	ADJ
dti-1375	36	49	incubator	incubator	NOUN
dti-1375	36	50	with	with	ADP
dti-1375	36	51	5	5	NUM
dti-1375	36	52	%	%	NOUN
dti-1375	36	53	co2	co2	NOUN
dti-1375	36	54	supply	supply	NOUN
dti-1375	36	55	.	.	PUNCT
dti-1375	37	1	for	for	ADP
dti-1375	37	2	treatments	treatment	NOUN
dti-1375	37	3	,	,	PUNCT
dti-1375	37	4	2	2	NUM
dti-1375	37	5	×	×	NOUN
dti-1375	37	6	105	105	NUM
dti-1375	37	7	cells	cell	NOUN
dti-1375	37	8	were	be	AUX
dti-1375	37	9	grown	grow	VERB
dti-1375	37	10	on	on	ADP
dti-1375	37	11	cover	cover	NOUN
dti-1375	37	12	glass	glass	NOUN
dti-1375	37	13	(	(	PUNCT
dti-1375	37	14	22	22	NUM
dti-1375	37	15	×	×	NOUN
dti-1375	37	16	22	22	NUM
dti-1375	37	17	mm	mm	NOUN
dti-1375	37	18	,	,	PUNCT
dti-1375	37	19	fisher	fisher	PROPN
dti-1375	37	20	scientific	scientific	PROPN
dti-1375	37	21	,	,	PUNCT
dti-1375	37	22	usa	usa	PROPN
dti-1375	37	23	)	)	PUNCT
dti-1375	37	24	in	in	ADP
dti-1375	37	25	a	a	DET
dti-1375	37	26	6	6	NUM
dti-1375	37	27	-	-	PUNCT
dti-1375	37	28	well	well	NOUN
dti-1375	37	29	culture	culture	NOUN
dti-1375	37	30	dish	dish	NOUN
dti-1375	37	31	(	(	PUNCT
dti-1375	37	32	nunc	nunc	NOUN
dti-1375	37	33	,	,	PUNCT
dti-1375	37	34	thermo	thermo	NOUN
dti-1375	37	35	scientific	scientific	NOUN
dti-1375	37	36	,	,	PUNCT
dti-1375	37	37	usa	usa	PROPN
dti-1375	37	38	)	)	PUNCT
dti-1375	37	39	and	and	CCONJ
dti-1375	37	40	incubated	incubate	VERB
dti-1375	37	41	in	in	ADP
dti-1375	37	42	complete	complete	ADJ
dti-1375	37	43	medium	medium	NOUN
dti-1375	37	44	either	either	CCONJ
dti-1375	37	45	with	with	ADP
dti-1375	37	46	doxorubicin	doxorubicin	PROPN
dti-1375	37	47	(	(	PUNCT
dti-1375	37	48	sigma	sigma	PROPN
dti-1375	37	49	-	-	PUNCT
dti-1375	37	50	aldrich	aldrich	PROPN
dti-1375	37	51	,	,	PUNCT
dti-1375	37	52	usa	usa	PROPN
dti-1375	37	53	)	)	PUNCT
dti-1375	37	54	or	or	CCONJ
dti-1375	37	55	with	with	ADP
dti-1375	37	56	17aag	17aag	NOUN
dti-1375	37	57	(	(	PUNCT
dti-1375	37	58	invivogen	invivogen	PROPN
dti-1375	37	59	,	,	PUNCT
dti-1375	37	60	usa	usa	PROPN
dti-1375	37	61	)	)	PUNCT
dti-1375	37	62	at	at	ADP
dti-1375	37	63	different	different	ADJ
dti-1375	37	64	time	time	NOUN
dti-1375	37	65	intervals	interval	NOUN
dti-1375	37	66	.	.	PUNCT
dti-1375	38	1	the	the	DET
dti-1375	38	2	effective	effective	ADJ
dti-1375	38	3	drug	drug	NOUN
dti-1375	38	4	concentrations	concentration	NOUN
dti-1375	38	5	were	be	AUX
dti-1375	38	6	standardized	standardize	VERB
dti-1375	38	7	by	by	ADP
dti-1375	38	8	analyzing	analyze	VERB
dti-1375	38	9	their	their	PRON
dti-1375	38	10	ability	ability	NOUN
dti-1375	38	11	to	to	PART
dti-1375	38	12	induce	induce	VERB
dti-1375	38	13	cytotoxicity	cytotoxicity	NOUN
dti-1375	38	14	in	in	ADP
dti-1375	38	15	case	case	NOUN
dti-1375	38	16	of	of	ADP
dti-1375	38	17	doxorubicin	doxorubicin	PROPN
dti-1375	38	18	and	and	CCONJ
dti-1375	38	19	to	to	PART
dti-1375	38	20	degrade	degrade	VERB
dti-1375	38	21	90	90	NUM
dti-1375	38	22	%	%	NOUN
dti-1375	38	23	of	of	ADP
dti-1375	38	24	hsp90	hsp90	ADJ
dti-1375	38	25	client	client	NOUN
dti-1375	38	26	proteins	protein	NOUN
dti-1375	38	27	in	in	ADP
dti-1375	38	28	case	case	NOUN
dti-1375	38	29	of	of	ADP
dti-1375	38	30	17aag	17aag	NOUN
dti-1375	38	31	.	.	PUNCT
dti-1375	39	1	the	the	DET
dti-1375	39	2	concentration	concentration	NOUN
dti-1375	39	3	used	use	VERB
dti-1375	39	4	throughout	throughout	ADP
dti-1375	39	5	the	the	DET
dti-1375	39	6	manuscript	manuscript	NOUN
dti-1375	39	7	for	for	ADP
dti-1375	39	8	doxorubicin	doxorubicin	PROPN
dti-1375	39	9	was	be	AUX
dti-1375	39	10	0.1	0.1	NUM
dti-1375	39	11	µm	µm	ADP
dti-1375	39	12	and	and	CCONJ
dti-1375	39	13	for	for	ADP
dti-1375	39	14	17aag	17aag	NOUN
dti-1375	39	15	it	it	PRON
dti-1375	39	16	was	be	AUX
dti-1375	39	17	2	2	NUM
dti-1375	39	18	µm	µm	NOUN
dti-1375	39	19	.	.	PUNCT
dti-1375	39	20	http://www.la-press.com	http://www.la-press.com	X
dti-1375	40	1	hsp90	hsp90	ADJ
dti-1375	40	2	inhibition	inhibition	NOUN
dti-1375	40	3	accelerates	accelerate	VERB
dti-1375	40	4	senescence	senescence	NOUN
dti-1375	40	5	drug	drug	NOUN
dti-1375	40	6	target	target	NOUN
dti-1375	40	7	insights	insight	NOUN
dti-1375	40	8	2012:6	2012:6	NUM
dti-1375	40	9	21	21	NUM
dti-1375	40	10	cell	cell	NOUN
dti-1375	40	11	based	base	VERB
dti-1375	40	12	assays	assay	NOUN
dti-1375	40	13	fluorescence	fluorescence	VERB
dti-1375	40	14	activated	activate	VERB
dti-1375	40	15	cell	cell	NOUN
dti-1375	40	16	sorting	sorting	NOUN
dti-1375	40	17	(	(	PUNCT
dti-1375	40	18	facs	fac	NOUN
dti-1375	40	19	,	,	PUNCT
dti-1375	40	20	facscalibur	facscalibur	PROPN
dti-1375	40	21	,	,	PUNCT
dti-1375	40	22	becton	becton	PROPN
dti-1375	40	23	dickinson	dickinson	PROPN
dti-1375	40	24	,	,	PUNCT
dti-1375	40	25	usa	usa	PROPN
dti-1375	40	26	)	)	PUNCT
dti-1375	40	27	analysis	analysis	NOUN
dti-1375	40	28	for	for	ADP
dti-1375	40	29	dna	dna	PROPN
dti-1375	40	30	content	content	NOUN
dti-1375	40	31	was	be	AUX
dti-1375	40	32	performed	perform	VERB
dti-1375	40	33	by	by	ADP
dti-1375	40	34	staining	stain	VERB
dti-1375	40	35	cells	cell	NOUN
dti-1375	40	36	with	with	ADP
dti-1375	40	37	propidium	propidium	NOUN
dti-1375	40	38	iodide	iodide	NOUN
dti-1375	40	39	(	(	PUNCT
dti-1375	40	40	50	50	NUM
dti-1375	40	41	µg	µg	NOUN
dti-1375	40	42	/	/	SYM
dti-1375	40	43	ml	ml	NOUN
dti-1375	40	44	;	;	PUNCT
dti-1375	40	45	sigma	sigma	PROPN
dti-1375	40	46	-	-	PUNCT
dti-1375	40	47	aldrich	aldrich	PROPN
dti-1375	40	48	,	,	PUNCT
dti-1375	40	49	usa	usa	PROPN
dti-1375	40	50	)	)	PUNCT
dti-1375	40	51	.	.	PUNCT
dti-1375	41	1	to	to	PART
dti-1375	41	2	measure	measure	VERB
dti-1375	41	3	intracellular	intracellular	ADJ
dti-1375	41	4	reactive	reactive	ADJ
dti-1375	41	5	oxygen	oxygen	NOUN
dti-1375	41	6	species	specie	NOUN
dti-1375	41	7	,	,	PUNCT
dti-1375	41	8	[	[	X
dti-1375	41	9	(	(	PUNCT
dti-1375	41	10	ros)i	ros)i	NOUN
dti-1375	41	11	]	]	PUNCT
dti-1375	41	12	,	,	PUNCT
dti-1375	41	13	cells	cell	NOUN
dti-1375	41	14	were	be	AUX
dti-1375	41	15	stained	stain	VERB
dti-1375	41	16	with	with	ADP
dti-1375	41	17	cm	cm	NOUN
dti-1375	41	18	-	-	PUNCT
dti-1375	41	19	h2dcfda	h2dcfda	PROPN
dti-1375	41	20	(	(	PUNCT
dti-1375	41	21	5	5	NUM
dti-1375	41	22	µm	µm	NUM
dti-1375	41	23	;	;	PUNCT
dti-1375	41	24	dojindo	dojindo	PROPN
dti-1375	41	25	,	,	PUNCT
dti-1375	41	26	japan	japan	PROPN
dti-1375	41	27	)	)	PUNCT
dti-1375	41	28	,	,	PUNCT
dti-1375	41	29	to	to	PART
dti-1375	41	30	measure	measure	VERB
dti-1375	41	31	intracellular	intracellular	ADJ
dti-1375	41	32	calcium	calcium	NOUN
dti-1375	41	33	,	,	PUNCT
dti-1375	41	34	[	[	X
dti-1375	41	35	(	(	PUNCT
dti-1375	41	36	ca2+)i	ca2+)i	NOUN
dti-1375	41	37	]	]	PUNCT
dti-1375	41	38	,	,	PUNCT
dti-1375	41	39	cells	cell	NOUN
dti-1375	41	40	were	be	AUX
dti-1375	41	41	stained	stain	VERB
dti-1375	41	42	with	with	ADP
dti-1375	41	43	fluo	fluo	PROPN
dti-1375	41	44	3	3	NUM
dti-1375	41	45	-	-	PUNCT
dti-1375	41	46	am	am	NOUN
dti-1375	41	47	(	(	PUNCT
dti-1375	41	48	1	1	NUM
dti-1375	41	49	µm	µm	NUM
dti-1375	41	50	;	;	PUNCT
dti-1375	41	51	dojindo	dojindo	PROPN
dti-1375	41	52	,	,	PUNCT
dti-1375	41	53	japan	japan	PROPN
dti-1375	41	54	)	)	PUNCT
dti-1375	41	55	,	,	PUNCT
dti-1375	41	56	to	to	PART
dti-1375	41	57	measure	measure	VERB
dti-1375	41	58	a	a	DET
dti-1375	41	59	change	change	NOUN
dti-1375	41	60	in	in	ADP
dti-1375	41	61	mitochondrial	mitochondrial	ADJ
dti-1375	41	62	membrane	membrane	NOUN
dti-1375	41	63	potential	potential	NOUN
dti-1375	41	64	(	(	PUNCT
dti-1375	41	65	∆ψm	∆ψm	PROPN
dti-1375	41	66	)	)	PUNCT
dti-1375	41	67	,	,	PUNCT
dti-1375	41	68	cells	cell	NOUN
dti-1375	41	69	were	be	AUX
dti-1375	41	70	stained	stain	VERB
dti-1375	41	71	with	with	ADP
dti-1375	41	72	jc1	jc1	PROPN
dti-1375	41	73	(	(	PUNCT
dti-1375	41	74	40	40	NUM
dti-1375	41	75	nm	nm	NOUN
dti-1375	41	76	;	;	PUNCT
dti-1375	41	77	invitrogen	invitrogen	PROPN
dti-1375	41	78	,	,	PUNCT
dti-1375	41	79	usa	usa	PROPN
dti-1375	41	80	)	)	PUNCT
dti-1375	41	81	.	.	PUNCT
dti-1375	42	1	after	after	ADP
dti-1375	42	2	incubation	incubation	NOUN
dti-1375	42	3	for	for	ADP
dti-1375	42	4	20	20	NUM
dti-1375	42	5	min	min	NOUN
dti-1375	42	6	in	in	ADP
dti-1375	42	7	the	the	DET
dti-1375	42	8	dark	dark	NOUN
dti-1375	42	9	,	,	PUNCT
dti-1375	42	10	cells	cell	NOUN
dti-1375	42	11	were	be	AUX
dti-1375	42	12	washed	wash	VERB
dti-1375	42	13	off	off	ADP
dti-1375	42	14	the	the	DET
dti-1375	42	15	fluorophore	fluorophore	NOUN
dti-1375	42	16	three	three	NUM
dti-1375	42	17	times	time	NOUN
dti-1375	42	18	with	with	ADP
dti-1375	42	19	pbs	pbs	PROPN
dti-1375	42	20	and	and	CCONJ
dti-1375	42	21	analyzed	analyze	VERB
dti-1375	42	22	in	in	ADP
dti-1375	42	23	moflow	moflow	NOUN
dti-1375	42	24	(	(	PUNCT
dti-1375	42	25	becton	becton	PROPN
dti-1375	42	26	dickinson	dickinson	PROPN
dti-1375	42	27	,	,	PUNCT
dti-1375	42	28	usa	usa	PROPN
dti-1375	42	29	)	)	PUNCT
dti-1375	42	30	.	.	PUNCT
dti-1375	43	1	each	each	DET
dti-1375	43	2	experiment	experiment	NOUN
dti-1375	43	3	was	be	AUX
dti-1375	43	4	repeated	repeat	VERB
dti-1375	43	5	a	a	DET
dti-1375	43	6	minimum	minimum	NOUN
dti-1375	43	7	of	of	ADP
dti-1375	43	8	three	three	NUM
dti-1375	43	9	for	for	ADP
dti-1375	43	10	reproducibility	reproducibility	NOUN
dti-1375	43	11	and	and	CCONJ
dti-1375	43	12	statistical	statistical	ADJ
dti-1375	43	13	significance	significance	NOUN
dti-1375	43	14	.	.	PUNCT
dti-1375	44	1	the	the	DET
dti-1375	44	2	data	datum	NOUN
dti-1375	44	3	were	be	AUX
dti-1375	44	4	analyzed	analyze	VERB
dti-1375	44	5	with	with	ADP
dti-1375	44	6	bd	bd	PROPN
dti-1375	44	7	cell	cell	NOUN
dti-1375	44	8	-	-	PUNCT
dti-1375	44	9	quest	quest	NOUN
dti-1375	44	10	pro	pro	ADJ
dti-1375	44	11	v5.2	v5.2	VERB
dti-1375	44	12	software	software	NOUN
dti-1375	44	13	.	.	PUNCT
dti-1375	45	1	senescence	senescence	NOUN
dti-1375	45	2	associated	associate	VERB
dti-1375	45	3	β	β	NOUN
dti-1375	45	4	-	-	NOUN
dti-1375	45	5	galactosidase	galactosidase	ADJ
dti-1375	45	6	(	(	PUNCT
dti-1375	45	7	sa	sa	NOUN
dti-1375	45	8	-	-	PUNCT
dti-1375	45	9	β	β	NOUN
dti-1375	45	10	-	-	ADJ
dti-1375	45	11	gal	gal	NOUN
dti-1375	45	12	)	)	PUNCT
dti-1375	45	13	staining	stain	VERB
dti-1375	45	14	the	the	DET
dti-1375	45	15	phase	phase	NOUN
dti-1375	45	16	-	-	PUNCT
dti-1375	45	17	contrast	contrast	NOUN
dti-1375	45	18	images	image	NOUN
dti-1375	45	19	of	of	ADP
dti-1375	45	20	cells	cell	NOUN
dti-1375	45	21	were	be	AUX
dti-1375	45	22	captured	capture	VERB
dti-1375	45	23	using	use	VERB
dti-1375	45	24	axiovert	axiovert	ADJ
dti-1375	45	25	200	200	NUM
dti-1375	45	26	microscope	microscope	NOUN
dti-1375	45	27	(	(	PUNCT
dti-1375	45	28	20×	20×	NUM
dti-1375	45	29	magnification	magnification	NOUN
dti-1375	45	30	;	;	PUNCT
dti-1375	45	31	carl	carl	PROPN
dti-1375	45	32	zeiss	zeiss	PROPN
dti-1375	45	33	,	,	PUNCT
dti-1375	45	34	germany	germany	PROPN
dti-1375	45	35	)	)	PUNCT
dti-1375	45	36	.	.	PUNCT
dti-1375	46	1	the	the	DET
dti-1375	46	2	sa	sa	PROPN
dti-1375	46	3	-	-	PUNCT
dti-1375	46	4	β	β	NOUN
dti-1375	46	5	-	-	ADJ
dti-1375	46	6	gal	gal	ADJ
dti-1375	46	7	staining	staining	NOUN
dti-1375	46	8	was	be	AUX
dti-1375	46	9	performed	perform	VERB
dti-1375	46	10	as	as	ADP
dti-1375	46	11	explained	explain	VERB
dti-1375	46	12	earlier13	earlier13	NOUN
dti-1375	46	13	and	and	CCONJ
dti-1375	46	14	observed	observe	VERB
dti-1375	46	15	under	under	ADP
dti-1375	46	16	the	the	DET
dti-1375	46	17	axiovert	axiovert	ADJ
dti-1375	46	18	200	200	NUM
dti-1375	46	19	microscope	microscope	NOUN
dti-1375	46	20	(	(	PUNCT
dti-1375	46	21	20×	20×	NUM
dti-1375	46	22	magnification	magnification	NOUN
dti-1375	46	23	)	)	PUNCT
dti-1375	46	24	.	.	PUNCT
dti-1375	47	1	reverse	reverse	VERB
dti-1375	47	2	transcriptase	transcriptase	NOUN
dti-1375	47	3	polymerase	polymerase	NOUN
dti-1375	47	4	chain	chain	NOUN
dti-1375	47	5	reaction	reaction	NOUN
dti-1375	47	6	(	(	PUNCT
dti-1375	47	7	rt	rt	NOUN
dti-1375	47	8	-	-	PUNCT
dti-1375	47	9	pcr	pcr	NOUN
dti-1375	47	10	)	)	PUNCT
dti-1375	47	11	the	the	DET
dti-1375	47	12	rna	rna	NOUN
dti-1375	47	13	was	be	AUX
dti-1375	47	14	isolated	isolate	VERB
dti-1375	47	15	using	use	VERB
dti-1375	47	16	trizol	trizol	PROPN
dti-1375	47	17	(	(	PUNCT
dti-1375	47	18	sigma	sigma	PROPN
dti-1375	47	19	-	-	PUNCT
dti-1375	47	20	aldrich	aldrich	PROPN
dti-1375	47	21	,	,	PUNCT
dti-1375	47	22	usa	usa	PROPN
dti-1375	47	23	)	)	PUNCT
dti-1375	47	24	method	method	NOUN
dti-1375	47	25	.	.	PUNCT
dti-1375	48	1	the	the	DET
dti-1375	48	2	first	first	ADJ
dti-1375	48	3	strand	strand	NOUN
dti-1375	48	4	cdna	cdna	PROPN
dti-1375	48	5	was	be	AUX
dti-1375	48	6	prepared	prepare	VERB
dti-1375	48	7	from	from	ADP
dti-1375	48	8	1	1	NUM
dti-1375	48	9	μg	μg	PROPN
dti-1375	48	10	total	total	NOUN
dti-1375	48	11	rna	rna	NOUN
dti-1375	48	12	using	use	VERB
dti-1375	48	13	prime	prime	ADJ
dti-1375	48	14	script	script	NOUN
dti-1375	48	15	1st	1st	ADJ
dti-1375	48	16	strand	strand	PROPN
dti-1375	48	17	cdna	cdna	PROPN
dti-1375	48	18	synthesis	synthesis	NOUN
dti-1375	48	19	kit	kit	NOUN
dti-1375	48	20	(	(	PUNCT
dti-1375	48	21	takara	takara	PROPN
dti-1375	48	22	bio	bio	PROPN
dti-1375	48	23	inc	inc	PROPN
dti-1375	48	24	.	.	PROPN
dti-1375	48	25	,	,	PUNCT
dti-1375	48	26	japan	japan	PROPN
dti-1375	48	27	)	)	PUNCT
dti-1375	48	28	.	.	PUNCT
dti-1375	49	1	the	the	DET
dti-1375	49	2	gene	gene	NOUN
dti-1375	49	3	specific	specific	ADJ
dti-1375	49	4	cdna	cdna	PROPN
dti-1375	49	5	amplifications	amplification	NOUN
dti-1375	49	6	were	be	AUX
dti-1375	49	7	performed	perform	VERB
dti-1375	49	8	using	use	VERB
dti-1375	49	9	qualitative	qualitative	ADJ
dti-1375	49	10	pcr	pcr	ADJ
dti-1375	49	11	primers	primer	NOUN
dti-1375	49	12	in	in	ADP
dti-1375	49	13	a	a	DET
dti-1375	49	14	dual	dual	ADJ
dti-1375	49	15	block	block	NOUN
dti-1375	49	16	pcr	pcr	NOUN
dti-1375	49	17	machine	machine	NOUN
dti-1375	49	18	(	(	PUNCT
dti-1375	49	19	dna	dna	NOUN
dti-1375	49	20	engine	engine	NOUN
dti-1375	49	21	;	;	PUNCT
dti-1375	49	22	bio	bio	NOUN
dti-1375	49	23	-	-	PROPN
dti-1375	49	24	rad	rad	PROPN
dti-1375	49	25	,	,	PUNCT
dti-1375	49	26	usa	usa	PROPN
dti-1375	49	27	)	)	PUNCT
dti-1375	49	28	.	.	PUNCT
dti-1375	50	1	the	the	DET
dti-1375	50	2	primers	primer	NOUN
dti-1375	50	3	used	use	VERB
dti-1375	50	4	were	be	AUX
dti-1375	50	5	cell	cell	NOUN
dti-1375	50	6	cycle	cycle	NOUN
dti-1375	50	7	regulators	regulator	NOUN
dti-1375	50	8	:	:	PUNCT
dti-1375	50	9	p21	p21	NOUN
dti-1375	50	10	(	(	PUNCT
dti-1375	50	11	accession	accession	NOUN
dti-1375	50	12	no	no	INTJ
dti-1375	50	13	.	.	PUNCT
dti-1375	50	14	nm_000389.3	nm_000389.3	PROPN
dti-1375	50	15	)	)	PUNCT
dti-1375	50	16	,	,	PUNCT
dti-1375	50	17	sense	sense	NOUN
dti-1375	50	18	,	,	PUNCT
dti-1375	50	19	5′-ggagctgggcgc	5′-ggagctgggcgc	PROPN
dti-1375	50	20	ggattc-3′	ggattc-3′	ADJ
dti-1375	50	21	,	,	PUNCT
dti-1375	50	22	antisense	antisense	NOUN
dti-1375	50	23	,	,	PUNCT
dti-1375	50	24	5′-aggccctcgcgc	5′-aggccctcgcgc	PROPN
dti-1375	50	25	ttccag3′	ttccag3′	PROPN
dti-1375	50	26	;	;	PUNCT
dti-1375	50	27	p53	p53	NOUN
dti-1375	50	28	(	(	PUNCT
dti-1375	50	29	accession	accession	NOUN
dti-1375	50	30	no	no	INTJ
dti-1375	50	31	.	.	PUNCT
dti-1375	50	32	nm_000546.4	nm_000546.4	ADJ
dti-1375	50	33	)	)	PUNCT
dti-1375	50	34	,	,	PUNCT
dti-1375	50	35	sense	sense	NOUN
dti-1375	50	36	,	,	PUNCT
dti-1375	50	37	5′-ttgcgttcgggctgggag-3′	5′-ttgcgttcgggctgggag-3′	PRON
dti-1375	50	38	,	,	PUNCT
dti-1375	50	39	antisense	antisense	NOUN
dti-1375	50	40	,	,	PUNCT
dti-1375	50	41	5′-gccgccggtgtaggagct-3′	5′-gccgccggtgtaggagct-3′	NUM
dti-1375	50	42	;	;	PUNCT
dti-1375	50	43	p16	p16	NOUN
dti-1375	50	44	(	(	PUNCT
dti-1375	50	45	accession	accession	NOUN
dti-1375	50	46	no	no	INTJ
dti-1375	50	47	.	.	PUNCT
dti-1375	50	48	nm_000077.4	nm_000077.4	NUM
dti-1375	50	49	)	)	PUNCT
dti-1375	50	50	,	,	PUNCT
dti-1375	50	51	sense	sense	NOUN
dti-1375	50	52	,	,	PUNCT
dti-1375	50	53	5′-attgaattcatg	5′-attgaattcatg	NUM
dti-1375	50	54	gagccggcggcg-3′	gagccggcggcg-3′	ADJ
dti-1375	50	55	,	,	PUNCT
dti-1375	50	56	antisense	antisense	NOUN
dti-1375	50	57	,	,	PUNCT
dti-1375	50	58	5′attgga	5′attgga	NUM
dti-1375	50	59	tccatcggggatgtctgag-3′	tccatcggggatgtctgag-3′	NOUN
dti-1375	50	60	;	;	PUNCT
dti-1375	50	61	hsps	hsps	PROPN
dti-1375	50	62	:	:	PUNCT
dti-1375	50	63	hsp70	hsp70	NOUN
dti-1375	50	64	(	(	PUNCT
dti-1375	50	65	accession	accession	NOUN
dti-1375	50	66	no	no	INTJ
dti-1375	50	67	.	.	PUNCT
dti-1375	51	1	nm_005346.4	nm_005346.4	PROPN
dti-1375	51	2	)	)	PUNCT
dti-1375	51	3	,	,	PUNCT
dti-1375	51	4	sense	sense	NOUN
dti-1375	51	5	,	,	PUNCT
dti-1375	51	6	5′-cca	5′-cca	NUM
dti-1375	51	7	tggtgctgaccaagatgaag-3′	tggtgctgaccaagatgaag-3′	ADJ
dti-1375	51	8	,	,	PUNCT
dti-1375	51	9	antisense	antisense	NOUN
dti-1375	51	10	,	,	PUNCT
dti-1375	51	11	5′-tcgtcgatcgtcaggatggacac-3′	5′-tcgtcgatcgtcaggatggacac-3′	NUM
dti-1375	51	12	;	;	PUNCT
dti-1375	52	1	hsp27	hsp27	NOUN
dti-1375	52	2	(	(	PUNCT
dti-1375	52	3	accession	accession	NOUN
dti-1375	52	4	no	no	INTJ
dti-1375	52	5	.	.	PUNCT
dti-1375	52	6	nm_001540.3	nm_001540.3	PROPN
dti-1375	52	7	)	)	PUNCT
dti-1375	52	8	,	,	PUNCT
dti-1375	52	9	sense	sense	NOUN
dti-1375	52	10	,	,	PUNCT
dti-1375	52	11	5′-tccctggatgtcaaccacttcg-3′	5′-tccctggatgtcaaccacttcg-3′	NUM
dti-1375	52	12	,	,	PUNCT
dti-1375	52	13	antisense	antisense	NOUN
dti-1375	52	14	,	,	PUNCT
dti-1375	52	15	5′-gggacagggaggaggaaacttg-3′	5′-gggacagggaggaggaaacttg-3′	NUM
dti-1375	52	16	;	;	PUNCT
dti-1375	52	17	hsp90	hsp90	NOUN
dti-1375	52	18	(	(	PUNCT
dti-1375	52	19	accession	accession	NOUN
dti-1375	52	20	no	no	INTJ
dti-1375	52	21	.	.	PUNCT
dti-1375	52	22	nm_001017963.2	nm_001017963.2	NUM
dti-1375	52	23	)	)	PUNCT
dti-1375	52	24	,	,	PUNCT
dti-1375	52	25	5′-tccggtatgaaagct	5′-tccggtatgaaagct	NUM
dti-1375	52	26	tgacag-3′	tgacag-3′	NOUN
dti-1375	52	27	,	,	PUNCT
dti-1375	52	28	antisense	antisense	NOUN
dti-1375	52	29	,	,	PUNCT
dti-1375	52	30	5′-ctggtccagatgggctttgtt-3′	5′-ctggtccagatgggctttgtt-3′	NUM
dti-1375	52	31	;	;	PUNCT
dti-1375	52	32	gapdh	gapdh	NOUN
dti-1375	52	33	,	,	PUNCT
dti-1375	52	34	(	(	PUNCT
dti-1375	52	35	accession	accession	NOUN
dti-1375	52	36	no	no	PROPN
dti-1375	52	37	.	.	PUNCT
dti-1375	52	38	nm_002046.3	nm_002046.3	PROPN
dti-1375	52	39	)	)	PUNCT
dti-1375	52	40	,	,	PUNCT
dti-1375	52	41	5′-tga	5′-tga	PROPN
dti-1375	52	42	aggtcggtgtgaacggatttg-3′	aggtcggtgtgaacggatttg-3′	NOUN
dti-1375	52	43	,	,	PUNCT
dti-1375	52	44	antisense	antisense	NOUN
dti-1375	52	45	,	,	PUNCT
dti-1375	52	46	5′-tgatggcatggactgtggtcatga-3′.	5′-tgatggcatggactgtggtcatga-3′.	NUM
dti-1375	52	47	quantification	quantification	NOUN
dti-1375	52	48	of	of	ADP
dti-1375	52	49	blots	blot	NOUN
dti-1375	52	50	was	be	AUX
dti-1375	52	51	performed	perform	VERB
dti-1375	52	52	using	use	VERB
dti-1375	52	53	image	image	NOUN
dti-1375	52	54	j	j	PROPN
dti-1375	52	55	software	software	NOUN
dti-1375	52	56	.	.	PUNCT
dti-1375	53	1	immunoblot	immunoblot	NOUN
dti-1375	53	2	analyses	analysis	NOUN
dti-1375	53	3	cell	cell	NOUN
dti-1375	53	4	lysates	lysate	NOUN
dti-1375	53	5	were	be	AUX
dti-1375	53	6	prepared	prepare	VERB
dti-1375	53	7	using	use	VERB
dti-1375	53	8	hepes	hepe	NOUN
dti-1375	53	9	lysis	lysis	NOUN
dti-1375	53	10	buffer	buffer	NOUN
dti-1375	53	11	(	(	PUNCT
dti-1375	53	12	20	20	NUM
dti-1375	53	13	mm	mm	PROPN
dti-1375	53	14	hepes	hepe	NOUN
dti-1375	53	15	,	,	PUNCT
dti-1375	53	16	10	10	NUM
dti-1375	53	17	mm	mm	NOUN
dti-1375	53	18	nacl	nacl	NOUN
dti-1375	53	19	,	,	PUNCT
dti-1375	53	20	1.5	1.5	NUM
dti-1375	53	21	mm	mm	NOUN
dti-1375	53	22	mgcl2	mgcl2	PROPN
dti-1375	53	23	,	,	PUNCT
dti-1375	53	24	0.1	0.1	NUM
dti-1375	53	25	%	%	NOUN
dti-1375	53	26	triton	triton	PROPN
dti-1375	53	27	x-100	x-100	PROPN
dti-1375	53	28	,	,	PUNCT
dti-1375	53	29	ph	ph	X
dti-1375	53	30	7.6	7.6	NUM
dti-1375	53	31	)	)	PUNCT
dti-1375	53	32	,	,	PUNCT
dti-1375	53	33	20	20	NUM
dti-1375	53	34	μg	μg	PROPN
dti-1375	53	35	total	total	ADJ
dti-1375	53	36	protein	protein	NOUN
dti-1375	53	37	was	be	AUX
dti-1375	53	38	run	run	VERB
dti-1375	53	39	on	on	ADP
dti-1375	53	40	10	10	NUM
dti-1375	53	41	%	%	NOUN
dti-1375	53	42	sds	sds	NOUN
dti-1375	53	43	-	-	PUNCT
dti-1375	53	44	page	page	NOUN
dti-1375	53	45	and	and	CCONJ
dti-1375	53	46	was	be	AUX
dti-1375	53	47	transferred	transfer	VERB
dti-1375	53	48	on	on	ADP
dti-1375	53	49	to	to	ADP
dti-1375	53	50	nitrocellulose	nitrocellulose	NOUN
dti-1375	53	51	membrane	membrane	NOUN
dti-1375	53	52	.	.	PUNCT
dti-1375	54	1	the	the	DET
dti-1375	54	2	primary	primary	ADJ
dti-1375	54	3	antibodies	antibody	NOUN
dti-1375	54	4	,	,	PUNCT
dti-1375	54	5	hrpoand	hrpoand	PROPN
dti-1375	54	6	fitc	fitc	PROPN
dti-1375	54	7	-	-	PUNCT
dti-1375	54	8	conjugated	conjugate	VERB
dti-1375	54	9	secondary	secondary	ADJ
dti-1375	54	10	antibodies	antibody	NOUN
dti-1375	54	11	were	be	AUX
dti-1375	54	12	obtained	obtain	VERB
dti-1375	54	13	from	from	ADP
dti-1375	54	14	santa	santa	PROPN
dti-1375	54	15	cruz	cruz	PROPN
dti-1375	54	16	biotechnology	biotechnology	PROPN
dti-1375	54	17	inc	inc	PROPN
dti-1375	54	18	.	.	PROPN
dti-1375	54	19	,	,	PUNCT
dti-1375	54	20	(	(	PUNCT
dti-1375	54	21	usa	usa	PROPN
dti-1375	54	22	)	)	PUNCT
dti-1375	54	23	.	.	PUNCT
dti-1375	55	1	laser	laser	NOUN
dti-1375	55	2	scanning	scan	VERB
dti-1375	55	3	confocal	confocal	ADJ
dti-1375	55	4	imaging	imaging	NOUN
dti-1375	55	5	microscopy	microscopy	NOUN
dti-1375	55	6	staining	stain	VERB
dti-1375	55	7	for	for	ADP
dti-1375	55	8	mitochondria	mitochondria	NOUN
dti-1375	55	9	and	and	CCONJ
dti-1375	55	10	actin	actin	NOUN
dti-1375	55	11	was	be	AUX
dti-1375	55	12	performed	perform	VERB
dti-1375	55	13	in	in	ADP
dti-1375	55	14	cells	cell	NOUN
dti-1375	55	15	with	with	ADP
dti-1375	55	16	cmx	cmx	NOUN
dti-1375	55	17	-	-	PROPN
dti-1375	55	18	ros	ros	PROPN
dti-1375	55	19	(	(	PUNCT
dti-1375	55	20	200	200	NUM
dti-1375	55	21	nm	nm	NOUN
dti-1375	55	22	;	;	PUNCT
dti-1375	55	23	invitrogen	invitrogen	PROPN
dti-1375	55	24	,	,	PUNCT
dti-1375	55	25	usa	usa	PROPN
dti-1375	55	26	)	)	PUNCT
dti-1375	55	27	and	and	CCONJ
dti-1375	55	28	oregon	oregon	PROPN
dti-1375	55	29	green	green	PROPN
dti-1375	55	30	phalloidin	phalloidin	PROPN
dti-1375	55	31	(	(	PUNCT
dti-1375	55	32	50	50	NUM
dti-1375	55	33	nm	nm	NOUN
dti-1375	55	34	;	;	PUNCT
dti-1375	55	35	invitrogen	invitrogen	PROPN
dti-1375	55	36	,	,	PUNCT
dti-1375	55	37	usa	usa	PROPN
dti-1375	55	38	)	)	PUNCT
dti-1375	55	39	respectively	respectively	ADV
dti-1375	55	40	and	and	CCONJ
dti-1375	55	41	nucleus	nucleus	NOUN
dti-1375	55	42	was	be	AUX
dti-1375	55	43	stained	stain	VERB
dti-1375	55	44	with	with	ADP
dti-1375	55	45	dapi	dapi	PROPN
dti-1375	55	46	(	(	PUNCT
dti-1375	55	47	50	50	NUM
dti-1375	55	48	nm	nm	NOUN
dti-1375	55	49	;	;	PUNCT
dti-1375	55	50	vectashield	vectashield	VERB
dti-1375	55	51	,	,	PUNCT
dti-1375	55	52	vector	vector	NOUN
dti-1375	55	53	labs	labs	PROPN
dti-1375	55	54	,	,	PUNCT
dti-1375	55	55	usa	usa	PROPN
dti-1375	55	56	)	)	PUNCT
dti-1375	55	57	and	and	CCONJ
dti-1375	55	58	observed	observe	VERB
dti-1375	55	59	under	under	ADP
dti-1375	55	60	laser	laser	NOUN
dti-1375	55	61	scanning	scan	VERB
dti-1375	55	62	confocal	confocal	ADJ
dti-1375	55	63	imaging	imaging	NOUN
dti-1375	55	64	microscope	microscope	NOUN
dti-1375	55	65	(	(	PUNCT
dti-1375	55	66	leica	leica	PROPN
dti-1375	55	67	tcs	tcs	PROPN
dti-1375	55	68	sp5	sp5	PROPN
dti-1375	55	69	,	,	PUNCT
dti-1375	55	70	leica	leica	PROPN
dti-1375	55	71	microsystems	microsystem	NOUN
dti-1375	55	72	,	,	PUNCT
dti-1375	55	73	germany	germany	PROPN
dti-1375	55	74	)	)	PUNCT
dti-1375	55	75	.	.	PUNCT
dti-1375	56	1	all	all	DET
dti-1375	56	2	immunoflourescence	immunoflourescence	NOUN
dti-1375	56	3	experiments	experiment	NOUN
dti-1375	56	4	were	be	AUX
dti-1375	56	5	performed	perform	VERB
dti-1375	56	6	on	on	ADP
dti-1375	56	7	cells	cell	NOUN
dti-1375	56	8	grown	grow	VERB
dti-1375	56	9	on	on	ADP
dti-1375	56	10	cover	cover	NOUN
dti-1375	56	11	glasses	glass	NOUN
dti-1375	56	12	,	,	PUNCT
dti-1375	56	13	with	with	ADP
dti-1375	56	14	p16	p16	NOUN
dti-1375	56	15	,	,	PUNCT
dti-1375	56	16	trimethyl	trimethyl	PROPN
dti-1375	56	17	histone	histone	NOUN
dti-1375	56	18	(	(	PUNCT
dti-1375	56	19	h3k4me3	h3k4me3	NOUN
dti-1375	56	20	)	)	PUNCT
dti-1375	56	21	and	and	CCONJ
dti-1375	56	22	γh2ax	γh2ax	PROPN
dti-1375	56	23	antibodies	antibodie	VERB
dti-1375	56	24	(	(	PUNCT
dti-1375	56	25	santa	santa	PROPN
dti-1375	56	26	cruz	cruz	PROPN
dti-1375	56	27	biotechnology	biotechnology	PROPN
dti-1375	56	28	inc	inc	PROPN
dti-1375	56	29	.	.	PROPN
dti-1375	56	30	,	,	PUNCT
dti-1375	56	31	usa	usa	PROPN
dti-1375	56	32	)	)	PUNCT
dti-1375	56	33	.	.	PUNCT
dti-1375	57	1	rhodamine	rhodamine	NOUN
dti-1375	57	2	123	123	NUM
dti-1375	57	3	(	(	PUNCT
dti-1375	57	4	rh123	rh123	NOUN
dti-1375	57	5	)	)	PUNCT
dti-1375	57	6	efflux	efflux	VERB
dti-1375	57	7	assay	assay	NOUN
dti-1375	57	8	cells	cell	NOUN
dti-1375	57	9	were	be	AUX
dti-1375	57	10	incubated	incubate	VERB
dti-1375	57	11	with	with	ADP
dti-1375	57	12	rh123	rh123	NOUN
dti-1375	57	13	(	(	PUNCT
dti-1375	57	14	1	1	NUM
dti-1375	57	15	µm	µm	NUM
dti-1375	57	16	;	;	PUNCT
dti-1375	57	17	dojindo	dojindo	PROPN
dti-1375	57	18	,	,	PUNCT
dti-1375	57	19	japan	japan	PROPN
dti-1375	57	20	)	)	PUNCT
dti-1375	57	21	and	and	CCONJ
dti-1375	57	22	analyzed	analyze	VERB
dti-1375	57	23	in	in	ADP
dti-1375	57	24	the	the	DET
dti-1375	57	25	facscalibur	facscalibur	NOUN
dti-1375	57	26	.	.	PUNCT
dti-1375	58	1	the	the	DET
dti-1375	58	2	rh123	rh123	PROPN
dti-1375	58	3	efflux	efflux	PROPN
dti-1375	58	4	ratio	ratio	NOUN
dti-1375	58	5	was	be	AUX
dti-1375	58	6	calculated	calculate	VERB
dti-1375	58	7	by	by	ADP
dti-1375	58	8	dividing	divide	VERB
dti-1375	58	9	the	the	DET
dti-1375	58	10	mean	mean	ADJ
dti-1375	58	11	channel	channel	NOUN
dti-1375	58	12	number	number	NOUN
dti-1375	58	13	with	with	ADP
dti-1375	58	14	cyclosporin	cyclosporin	PROPN
dti-1375	58	15	a	a	PRON
dti-1375	58	16	(	(	PUNCT
dti-1375	58	17	csa	csa	PROPN
dti-1375	58	18	)	)	PUNCT
dti-1375	58	19	and	and	CCONJ
dti-1375	58	20	mean	mean	ADJ
dti-1375	58	21	channel	channel	NOUN
dti-1375	58	22	number	number	NOUN
dti-1375	58	23	with	with	ADP
dti-1375	58	24	rh123	rh123	NOUN
dti-1375	58	25	alone	alone	ADV
dti-1375	58	26	.	.	PUNCT
dti-1375	59	1	real	real	ADJ
dti-1375	59	2	-	-	PUNCT
dti-1375	59	3	time	time	NOUN
dti-1375	59	4	polymerase	polymerase	NOUN
dti-1375	59	5	chain	chain	NOUN
dti-1375	59	6	reaction	reaction	NOUN
dti-1375	59	7	(	(	PUNCT
dti-1375	59	8	real	real	ADJ
dti-1375	59	9	-	-	PUNCT
dti-1375	59	10	time	time	NOUN
dti-1375	59	11	pcr	pcr	NOUN
dti-1375	59	12	)	)	PUNCT
dti-1375	59	13	the	the	DET
dti-1375	59	14	telomerase	telomerase	NOUN
dti-1375	59	15	activity	activity	NOUN
dti-1375	59	16	was	be	AUX
dti-1375	59	17	measured	measure	VERB
dti-1375	59	18	by	by	ADP
dti-1375	59	19	quantitative	quantitative	ADJ
dti-1375	59	20	telomerase	telomerase	NOUN
dti-1375	59	21	detection	detection	NOUN
dti-1375	59	22	kit	kit	NOUN
dti-1375	59	23	(	(	PUNCT
dti-1375	59	24	us	us	PROPN
dti-1375	59	25	biomax	biomax	NOUN
dti-1375	59	26	,	,	PUNCT
dti-1375	59	27	usa	usa	PROPN
dti-1375	59	28	)	)	PUNCT
dti-1375	59	29	.	.	PUNCT
dti-1375	60	1	a	a	DET
dti-1375	60	2	standard	standard	ADJ
dti-1375	60	3	real	real	ADJ
dti-1375	60	4	time	time	NOUN
dti-1375	60	5	pcr	pcr	PROPN
dti-1375	60	6	was	be	AUX
dti-1375	60	7	run	run	VERB
dti-1375	60	8	in	in	ADP
dti-1375	60	9	realplex	realplex	ADJ
dti-1375	60	10	realtime	realtime	ADJ
dti-1375	60	11	pcr	pcr	ADJ
dti-1375	60	12	machine	machine	NOUN
dti-1375	60	13	(	(	PUNCT
dti-1375	60	14	eppendorf	eppendorf	PROPN
dti-1375	60	15	mastercycler	mastercycler	PROPN
dti-1375	60	16	ep	ep	PROPN
dti-1375	60	17	gradient	gradient	PROPN
dti-1375	60	18	s	s	PROPN
dti-1375	60	19	,	,	PUNCT
dti-1375	60	20	germany	germany	PROPN
dti-1375	60	21	)	)	PUNCT
dti-1375	60	22	with	with	ADP
dti-1375	60	23	the	the	DET
dti-1375	60	24	tsr	tsr	PROPN
dti-1375	60	25	oligonucleotide	oligonucleotide	NOUN
dti-1375	60	26	http://www.la-press.com	http://www.la-press.com	X
dti-1375	61	1	sarangi	sarangi	PROPN
dti-1375	61	2	et	et	PROPN
dti-1375	61	3	al	al	PROPN
dti-1375	61	4	22	22	NUM
dti-1375	61	5	drug	drug	NOUN
dti-1375	61	6	target	target	NOUN
dti-1375	61	7	insights	insight	NOUN
dti-1375	61	8	2012:6	2012:6	NUM
dti-1375	61	9	and	and	CCONJ
dti-1375	61	10	the	the	DET
dti-1375	61	11	telomerase	telomerase	NOUN
dti-1375	61	12	activity	activity	NOUN
dti-1375	61	13	was	be	AUX
dti-1375	61	14	calculated	calculate	VERB
dti-1375	61	15	from	from	ADP
dti-1375	61	16	the	the	DET
dti-1375	61	17	standard	standard	ADJ
dti-1375	61	18	curve	curve	NOUN
dti-1375	61	19	.	.	PUNCT
dti-1375	62	1	colony	colony	NOUN
dti-1375	62	2	forming	form	VERB
dti-1375	62	3	assay	assay	ADV
dti-1375	62	4	(	(	PUNCT
dti-1375	62	5	cfa	cfa	NOUN
dti-1375	62	6	)	)	PUNCT
dti-1375	62	7	cells	cell	NOUN
dti-1375	62	8	were	be	AUX
dti-1375	62	9	mixed	mix	VERB
dti-1375	62	10	with	with	ADP
dti-1375	62	11	molten	molten	ADJ
dti-1375	62	12	soft	soft	ADJ
dti-1375	62	13	agar	agar	NOUN
dti-1375	62	14	at	at	ADP
dti-1375	62	15	37	37	NUM
dti-1375	62	16	°	°	NOUN
dti-1375	62	17	c	c	NOUN
dti-1375	62	18	,	,	PUNCT
dti-1375	62	19	poured	pour	VERB
dti-1375	62	20	over	over	ADP
dti-1375	62	21	a	a	DET
dti-1375	62	22	base	base	NOUN
dti-1375	62	23	layer	layer	NOUN
dti-1375	62	24	of	of	ADP
dti-1375	62	25	agar	agar	NOUN
dti-1375	62	26	and	and	CCONJ
dti-1375	62	27	allowed	allow	VERB
dti-1375	62	28	to	to	PART
dti-1375	62	29	grow	grow	VERB
dti-1375	62	30	in	in	ADP
dti-1375	62	31	complete	complete	ADJ
dti-1375	62	32	medium	medium	NOUN
dti-1375	62	33	with	with	ADP
dti-1375	62	34	5	5	NUM
dti-1375	62	35	%	%	NOUN
dti-1375	62	36	co2	co2	NOUN
dti-1375	62	37	supply	supply	NOUN
dti-1375	62	38	.	.	PUNCT
dti-1375	63	1	after	after	ADP
dti-1375	63	2	eight	eight	NUM
dti-1375	63	3	days	day	NOUN
dti-1375	63	4	,	,	PUNCT
dti-1375	63	5	cells	cell	NOUN
dti-1375	63	6	were	be	AUX
dti-1375	63	7	stained	stain	VERB
dti-1375	63	8	with	with	ADP
dti-1375	63	9	0.1	0.1	NUM
dti-1375	63	10	%	%	NOUN
dti-1375	63	11	crystal	crystal	NOUN
dti-1375	63	12	violet	violet	NOUN
dti-1375	63	13	and	and	CCONJ
dti-1375	63	14	observed	observe	VERB
dti-1375	63	15	under	under	ADP
dti-1375	63	16	axiovert	axiovert	ADJ
dti-1375	63	17	200	200	NUM
dti-1375	63	18	microscope	microscope	NOUN
dti-1375	63	19	in	in	ADP
dti-1375	63	20	differential	differential	ADJ
dti-1375	63	21	interference	interference	NOUN
dti-1375	63	22	contrast	contrast	NOUN
dti-1375	63	23	microscope	microscope	NOUN
dti-1375	63	24	(	(	PUNCT
dti-1375	63	25	dic	dic	ADJ
dti-1375	63	26	,	,	PUNCT
dti-1375	63	27	5×	5×	ADJ
dti-1375	63	28	magnification	magnification	NOUN
dti-1375	63	29	)	)	PUNCT
dti-1375	63	30	.	.	PUNCT
dti-1375	64	1	the	the	DET
dti-1375	64	2	colony	colony	NOUN
dti-1375	64	3	size	size	NOUN
dti-1375	64	4	in	in	ADP
dti-1375	64	5	micro	micro	ADJ
dti-1375	64	6	meters	meter	NOUN
dti-1375	64	7	was	be	AUX
dti-1375	64	8	calculated	calculate	VERB
dti-1375	64	9	from	from	ADP
dti-1375	64	10	πr2	πr2	NOUN
dti-1375	64	11	and	and	CCONJ
dti-1375	64	12	plotted	plot	VERB
dti-1375	64	13	.	.	PUNCT
dti-1375	65	1	neo	neo	NOUN
dti-1375	65	2	-	-	NOUN
dti-1375	65	3	vascularization	vascularization	NOUN
dti-1375	65	4	assay	assay	NOUN
dti-1375	65	5	cover	cover	NOUN
dti-1375	65	6	glasses	glass	NOUN
dti-1375	65	7	were	be	AUX
dti-1375	65	8	pre	pre	ADJ
dti-1375	65	9	-	-	VERB
dti-1375	65	10	coated	coated	ADJ
dti-1375	65	11	with	with	ADP
dti-1375	65	12	matrigel	matrigel	NOUN
dti-1375	65	13	(	(	PUNCT
dti-1375	65	14	bd	bd	PROPN
dti-1375	65	15	biosciences	biosciences	PROPN
dti-1375	65	16	,	,	PUNCT
dti-1375	65	17	usa	usa	PROPN
dti-1375	65	18	)	)	PUNCT
dti-1375	65	19	for	for	ADP
dti-1375	65	20	45	45	NUM
dti-1375	65	21	min	min	NOUN
dti-1375	65	22	and	and	CCONJ
dti-1375	65	23	cells	cell	NOUN
dti-1375	65	24	were	be	AUX
dti-1375	65	25	spread	spread	VERB
dti-1375	65	26	on	on	ADP
dti-1375	65	27	matrigel	matrigel	NOUN
dti-1375	65	28	,	,	PUNCT
dti-1375	65	29	incubated	incubate	VERB
dti-1375	65	30	with	with	ADP
dti-1375	65	31	complete	complete	ADJ
dti-1375	65	32	medium	medium	NOUN
dti-1375	65	33	containing	contain	VERB
dti-1375	65	34	the	the	DET
dti-1375	65	35	drugs	drug	NOUN
dti-1375	65	36	for	for	ADP
dti-1375	65	37	24	24	NUM
dti-1375	65	38	h	h	NOUN
dti-1375	65	39	and	and	CCONJ
dti-1375	65	40	the	the	DET
dti-1375	65	41	tube	tube	NOUN
dti-1375	65	42	or	or	CCONJ
dti-1375	65	43	colony	colony	NOUN
dti-1375	65	44	formation	formation	NOUN
dti-1375	65	45	was	be	AUX
dti-1375	65	46	observed	observe	VERB
dti-1375	65	47	under	under	ADP
dti-1375	65	48	axiovert	axiovert	ADJ
dti-1375	65	49	200	200	NUM
dti-1375	65	50	microscope	microscope	NOUN
dti-1375	65	51	in	in	ADP
dti-1375	65	52	dic	dic	PROPN
dti-1375	65	53	(	(	PUNCT
dti-1375	65	54	5×	5×	PROPN
dti-1375	65	55	magnification	magnification	NOUN
dti-1375	65	56	)	)	PUNCT
dti-1375	65	57	.	.	PUNCT
dti-1375	66	1	sirna	sirna	PROPN
dti-1375	66	2	knockdown	knockdown	PROPN
dti-1375	66	3	of	of	ADP
dti-1375	66	4	hsp90	hsp90	PROPN
dti-1375	66	5	hsp90	hsp90	PROPN
dti-1375	66	6	sirna	sirna	PROPN
dti-1375	66	7	was	be	AUX
dti-1375	66	8	designed	design	VERB
dti-1375	66	9	using	use	VERB
dti-1375	66	10	invitrogen	invitrogen	PROPN
dti-1375	66	11	block	block	NOUN
dti-1375	66	12	-	-	PUNCT
dti-1375	66	13	it	it	PRON
dti-1375	66	14	™	™	VERB
dti-1375	66	15	rnai	rnai	PROPN
dti-1375	66	16	designer	designer	NOUN
dti-1375	66	17	software	software	NOUN
dti-1375	66	18	from	from	ADP
dti-1375	66	19	hsp90	hsp90	ADJ
dti-1375	66	20	cdna	cdna	PROPN
dti-1375	66	21	(	(	PUNCT
dti-1375	66	22	accession	accession	NOUN
dti-1375	66	23	no	no	PROPN
dti-1375	66	24	.	.	PUNCT
dti-1375	66	25	nm_005348.2	nm_005348.2	PROPN
dti-1375	66	26	)	)	PUNCT
dti-1375	66	27	.	.	PUNCT
dti-1375	67	1	the	the	DET
dti-1375	67	2	three	three	NUM
dti-1375	67	3	sirna	sirna	PROPN
dti-1375	67	4	used	use	VERB
dti-1375	67	5	in	in	ADP
dti-1375	67	6	the	the	DET
dti-1375	67	7	present	present	ADJ
dti-1375	67	8	study	study	NOUN
dti-1375	67	9	were	be	AUX
dti-1375	67	10	,	,	PUNCT
dti-1375	67	11	oligo1	oligo1	ADJ
dti-1375	67	12	,	,	PUNCT
dti-1375	67	13	5′-gaa	5′-gaa	NUM
dti-1375	67	14	caaa	caaa	NOUN
dti-1375	67	15	caagatcgaactct-3′	caagatcgaactct-3′	NOUN
dti-1375	67	16	;	;	PUNCT
dti-1375	67	17	oligo2	oligo2	PROPN
dti-1375	67	18	,	,	PUNCT
dti-1375	67	19	5′-gaga	5′-gaga	PROPN
dti-1375	67	20	gagct	gagct	NOUN
dti-1375	67	21	catttcaaattcatca-3′	catttcaaattcatca-3′	NOUN
dti-1375	67	22	;	;	PUNCT
dti-1375	67	23	oligo3	oligo3	PROPN
dti-1375	67	24	,	,	PUNCT
dti-1375	67	25	5′-actctgg	5′-actctgg	PROPN
dti-1375	67	26	gaaagagctgcatattaa-3′.	gaaagagctgcatattaa-3′.	NOUN
dti-1375	67	27	the	the	DET
dti-1375	67	28	sirna	sirna	PROPN
dti-1375	67	29	was	be	AUX
dti-1375	67	30	introduced	introduce	VERB
dti-1375	67	31	into	into	ADP
dti-1375	67	32	the	the	DET
dti-1375	67	33	cells	cell	NOUN
dti-1375	67	34	using	use	VERB
dti-1375	67	35	nanoparticle	nanoparticle	NOUN
dti-1375	67	36	based	base	VERB
dti-1375	67	37	x	x	NOUN
dti-1375	67	38	-	-	NOUN
dti-1375	67	39	fect	fect	ADJ
dti-1375	67	40	transfection	transfection	NOUN
dti-1375	67	41	reagent	reagent	NOUN
dti-1375	67	42	(	(	PUNCT
dti-1375	67	43	clontech	clontech	NOUN
dti-1375	67	44	,	,	PUNCT
dti-1375	67	45	usa	usa	PROPN
dti-1375	67	46	)	)	PUNCT
dti-1375	67	47	.	.	PUNCT
dti-1375	68	1	evaluation	evaluation	NOUN
dti-1375	68	2	of	of	ADP
dti-1375	68	3	conditioned	condition	VERB
dti-1375	68	4	medium	medium	NOUN
dti-1375	68	5	(	(	PUNCT
dti-1375	68	6	cm	cm	NOUN
dti-1375	68	7	)	)	PUNCT
dti-1375	68	8	for	for	ADP
dti-1375	68	9	senescence	senescence	NOUN
dti-1375	68	10	promoting	promote	VERB
dti-1375	68	11	secretory	secretory	ADJ
dti-1375	68	12	factors	factor	NOUN
dti-1375	68	13	(	(	PUNCT
dti-1375	68	14	sasps	sasps	NOUN
dti-1375	68	15	)	)	PUNCT
dti-1375	68	16	imr-32	imr-32	ADP
dti-1375	68	17	cells	cell	NOUN
dti-1375	68	18	were	be	AUX
dti-1375	68	19	17aag	17aag	ADJ
dti-1375	68	20	pre	pre	VERB
dti-1375	68	21	-	-	VERB
dti-1375	68	22	treated	treat	VERB
dti-1375	68	23	for	for	ADP
dti-1375	68	24	24	24	NUM
dti-1375	68	25	h	h	NOUN
dti-1375	68	26	followed	follow	VERB
dti-1375	68	27	by	by	ADP
dti-1375	68	28	doxorubicin	doxorubicin	PROPN
dti-1375	68	29	for	for	ADP
dti-1375	68	30	5	5	NUM
dti-1375	68	31	days	day	NOUN
dti-1375	68	32	,	,	PUNCT
dti-1375	68	33	and	and	CCONJ
dti-1375	68	34	after	after	ADP
dti-1375	68	35	confirming	confirm	VERB
dti-1375	68	36	the	the	DET
dti-1375	68	37	sa	sa	PROPN
dti-1375	68	38	-	-	PUNCT
dti-1375	68	39	β	β	NOUN
dti-1375	68	40	-	-	ADJ
dti-1375	68	41	gal	gal	ADJ
dti-1375	68	42	positive	positive	ADJ
dti-1375	68	43	staining	staining	NOUN
dti-1375	68	44	of	of	ADP
dti-1375	68	45	cells	cell	NOUN
dti-1375	68	46	,	,	PUNCT
dti-1375	68	47	the	the	DET
dti-1375	68	48	cm	cm	NOUN
dti-1375	68	49	was	be	AUX
dti-1375	68	50	collected	collect	VERB
dti-1375	68	51	and	and	CCONJ
dti-1375	68	52	used	use	VERB
dti-1375	68	53	for	for	ADP
dti-1375	68	54	subsequent	subsequent	ADJ
dti-1375	68	55	experiments	experiment	NOUN
dti-1375	68	56	.	.	PUNCT
dti-1375	69	1	the	the	DET
dti-1375	69	2	immortalized	immortalize	VERB
dti-1375	69	3	human	human	ADJ
dti-1375	69	4	lens	lens	NOUN
dti-1375	69	5	epithelium	epithelium	NOUN
dti-1375	69	6	(	(	PUNCT
dti-1375	69	7	hle	hle	NOUN
dti-1375	69	8	)	)	PUNCT
dti-1375	69	9	cellssra01	cellssra01	NOUN
dti-1375	69	10	and	and	CCONJ
dti-1375	69	11	human	human	PROPN
dti-1375	69	12	t	t	PROPN
dti-1375	69	13	-	-	PUNCT
dti-1375	69	14	lymphocytesjurkat	lymphocytesjurkat	PROPN
dti-1375	69	15	(	(	PUNCT
dti-1375	69	16	0.1	0.1	NUM
dti-1375	69	17	×	×	NOUN
dti-1375	69	18	106	106	NUM
dti-1375	69	19	/	/	SYM
dti-1375	69	20	ml	ml	NOUN
dti-1375	69	21	)	)	PUNCT
dti-1375	69	22	grown	grow	VERB
dti-1375	69	23	on	on	ADP
dti-1375	69	24	cover	cover	NOUN
dti-1375	69	25	glasses	glass	NOUN
dti-1375	69	26	(	(	PUNCT
dti-1375	69	27	18	18	NUM
dti-1375	69	28	×	×	NOUN
dti-1375	69	29	18	18	NUM
dti-1375	69	30	mm	mm	NOUN
dti-1375	69	31	,	,	PUNCT
dti-1375	69	32	fisher	fisher	PROPN
dti-1375	69	33	scientific	scientific	PROPN
dti-1375	69	34	,	,	PUNCT
dti-1375	69	35	usa	usa	PROPN
dti-1375	69	36	)	)	PUNCT
dti-1375	69	37	were	be	AUX
dti-1375	69	38	replaced	replace	VERB
dti-1375	69	39	with	with	ADP
dti-1375	69	40	cm	cm	NOUN
dti-1375	69	41	and	and	CCONJ
dti-1375	69	42	maintained	maintain	VERB
dti-1375	69	43	at	at	ADP
dti-1375	69	44	standard	standard	ADJ
dti-1375	69	45	culture	culture	NOUN
dti-1375	69	46	conditions	condition	NOUN
dti-1375	69	47	.	.	PUNCT
dti-1375	70	1	the	the	DET
dti-1375	70	2	cells	cell	NOUN
dti-1375	70	3	were	be	AUX
dti-1375	70	4	monitored	monitor	VERB
dti-1375	70	5	every	every	DET
dti-1375	70	6	day	day	NOUN
dti-1375	70	7	under	under	ADP
dti-1375	70	8	the	the	DET
dti-1375	70	9	microscope	microscope	NOUN
dti-1375	70	10	for	for	ADP
dti-1375	70	11	typical	typical	ADJ
dti-1375	70	12	senescence	senescence	NOUN
dti-1375	70	13	morphology	morphology	NOUN
dti-1375	70	14	.	.	PUNCT
dti-1375	71	1	cells	cell	NOUN
dti-1375	71	2	that	that	PRON
dti-1375	71	3	exhibited	exhibit	VERB
dti-1375	71	4	senescence	senescence	NOUN
dti-1375	71	5	like	like	ADP
dti-1375	71	6	-	-	PUNCT
dti-1375	71	7	phenotype	phenotype	NOUN
dti-1375	71	8	were	be	AUX
dti-1375	71	9	stained	stain	VERB
dti-1375	71	10	for	for	ADP
dti-1375	71	11	β	β	NOUN
dti-1375	71	12	-	-	NOUN
dti-1375	71	13	galactosidase	galactosidase	NOUN
dti-1375	71	14	and	and	CCONJ
dti-1375	71	15	observed	observe	VERB
dti-1375	71	16	under	under	ADP
dti-1375	71	17	the	the	DET
dti-1375	71	18	microscope	microscope	NOUN
dti-1375	71	19	.	.	PUNCT
dti-1375	72	1	statistical	statistical	ADJ
dti-1375	72	2	analyses	analysis	NOUN
dti-1375	72	3	the	the	DET
dti-1375	72	4	data	datum	NOUN
dti-1375	72	5	presented	present	VERB
dti-1375	72	6	are	be	AUX
dti-1375	72	7	mean	mean	PROPN
dti-1375	72	8	±	±	NUM
dti-1375	72	9	sem	sem	NOUN
dti-1375	72	10	of	of	ADP
dti-1375	72	11	minimum	minimum	ADJ
dti-1375	72	12	three	three	NUM
dti-1375	72	13	independent	independent	ADJ
dti-1375	72	14	experiments	experiment	NOUN
dti-1375	72	15	.	.	PUNCT
dti-1375	73	1	the	the	DET
dti-1375	73	2	significance	significance	NOUN
dti-1375	73	3	was	be	AUX
dti-1375	73	4	calculated	calculate	VERB
dti-1375	73	5	by	by	ADP
dti-1375	73	6	student	student	NOUN
dti-1375	73	7	’s	’s	PART
dti-1375	73	8	t	t	PROPN
dti-1375	73	9	-	-	PUNCT
dti-1375	73	10	test	test	NOUN
dti-1375	73	11	(	(	PUNCT
dti-1375	73	12	sigmaplot	sigmaplot	NOUN
dti-1375	73	13	10.0	10.0	NUM
dti-1375	73	14	)	)	PUNCT
dti-1375	73	15	and	and	CCONJ
dti-1375	73	16	a	a	DET
dti-1375	73	17	value	value	NOUN
dti-1375	73	18	minimum	minimum	NOUN
dti-1375	73	19	of	of	ADP
dti-1375	73	20	p	p	NOUN
dti-1375	73	21	,	,	PUNCT
dti-1375	73	22	0.05	0.05	NUM
dti-1375	73	23	is	be	AUX
dti-1375	73	24	considered	consider	VERB
dti-1375	73	25	significant	significant	ADJ
dti-1375	73	26	.	.	PUNCT
dti-1375	74	1	results	result	VERB
dti-1375	74	2	17aag	17aag	ADJ
dti-1375	74	3	combination	combination	NOUN
dti-1375	74	4	decreases	decrease	VERB
dti-1375	74	5	doxorubicin	doxorubicin	PROPN
dti-1375	74	6	induced	induce	VERB
dti-1375	74	7	senescence	senescence	NOUN
dti-1375	74	8	response	response	NOUN
dti-1375	74	9	senescent	senescent	ADJ
dti-1375	74	10	cell	cell	NOUN
dti-1375	74	11	morphology	morphology	NOUN
dti-1375	74	12	is	be	AUX
dti-1375	74	13	typically	typically	ADV
dti-1375	74	14	associated	associate	VERB
dti-1375	74	15	with	with	ADP
dti-1375	74	16	increased	increase	VERB
dti-1375	74	17	nucleus	nucleus	NOUN
dti-1375	74	18	to	to	PART
dti-1375	74	19	cytoplasm	cytoplasm	VERB
dti-1375	74	20	ratio	ratio	NOUN
dti-1375	74	21	with	with	ADP
dti-1375	74	22	protracted	protract	VERB
dti-1375	74	23	cellular	cellular	ADJ
dti-1375	74	24	extensions	extension	NOUN
dti-1375	74	25	and	and	CCONJ
dti-1375	74	26	increased	increase	VERB
dti-1375	74	27	sa	sa	PROPN
dti-1375	74	28	-	-	PUNCT
dti-1375	74	29	β	β	NOUN
dti-1375	74	30	-	-	ADJ
dti-1375	74	31	gal	gal	ADJ
dti-1375	74	32	staining.14	staining.14	PROPN
dti-1375	74	33	at	at	ADP
dti-1375	74	34	first	first	ADV
dti-1375	74	35	,	,	PUNCT
dti-1375	74	36	various	various	ADJ
dti-1375	74	37	concentrations	concentration	NOUN
dti-1375	74	38	of	of	ADP
dti-1375	74	39	drugs	drug	NOUN
dti-1375	74	40	(	(	PUNCT
dti-1375	74	41	17aag0.5	17aag0.5	NUM
dti-1375	74	42	µm	µm	NOUN
dti-1375	74	43	to	to	ADP
dti-1375	74	44	10	10	NUM
dti-1375	74	45	µm	µm	NOUN
dti-1375	74	46	or	or	CCONJ
dti-1375	74	47	doxorubicin-0.1	doxorubicin-0.1	NOUN
dti-1375	74	48	µm	µm	ADP
dti-1375	74	49	to	to	ADP
dti-1375	74	50	2.0	2.0	NUM
dti-1375	74	51	µm	µm	NOUN
dti-1375	74	52	)	)	PUNCT
dti-1375	74	53	was	be	AUX
dti-1375	74	54	examined	examine	VERB
dti-1375	74	55	for	for	ADP
dti-1375	74	56	induced	induced	ADJ
dti-1375	74	57	cytotoxicity	cytotoxicity	NOUN
dti-1375	74	58	.	.	PUNCT
dti-1375	75	1	the	the	DET
dti-1375	75	2	optimum	optimum	ADJ
dti-1375	75	3	concentrations	concentration	NOUN
dti-1375	75	4	(	(	PUNCT
dti-1375	75	5	0.1	0.1	NUM
dti-1375	75	6	µm	µm	NOUN
dti-1375	75	7	for	for	ADP
dti-1375	75	8	doxorubicin	doxorubicin	PROPN
dti-1375	75	9	and	and	CCONJ
dti-1375	75	10	2.0	2.0	NUM
dti-1375	75	11	µm	µm	NOUN
dti-1375	75	12	for	for	ADP
dti-1375	75	13	17aag	17aag	NOUN
dti-1375	75	14	)	)	PUNCT
dti-1375	75	15	were	be	AUX
dti-1375	75	16	selected	select	VERB
dti-1375	75	17	where	where	SCONJ
dti-1375	75	18	we	we	PRON
dti-1375	75	19	observed	observe	VERB
dti-1375	75	20	90	90	NUM
dti-1375	75	21	%	%	NOUN
dti-1375	75	22	client	client	NOUN
dti-1375	75	23	protein	protein	NOUN
dti-1375	75	24	degradation	degradation	NOUN
dti-1375	75	25	for	for	ADP
dti-1375	75	26	hsp90	hsp90	ADJ
dti-1375	75	27	and	and	CCONJ
dti-1375	75	28	minimal	minimal	ADJ
dti-1375	75	29	dna	dna	ADJ
dti-1375	75	30	damage	damage	NOUN
dti-1375	75	31	response	response	NOUN
dti-1375	75	32	using	use	VERB
dti-1375	75	33	doxorubicin	doxorubicin	PROPN
dti-1375	75	34	.	.	PUNCT
dti-1375	76	1	to	to	PART
dti-1375	76	2	determine	determine	VERB
dti-1375	76	3	whether	whether	SCONJ
dti-1375	76	4	sa	sa	VERB
dti-1375	76	5	-	-	PUNCT
dti-1375	76	6	β	β	NOUN
dti-1375	76	7	-	-	ADJ
dti-1375	76	8	gal	gal	ADJ
dti-1375	76	9	positive	positive	ADJ
dti-1375	76	10	cells	cell	NOUN
dti-1375	76	11	are	be	AUX
dti-1375	76	12	induced	induce	VERB
dti-1375	76	13	by	by	ADP
dti-1375	76	14	doxorubicin	doxorubicin	PROPN
dti-1375	76	15	(	(	PUNCT
dti-1375	76	16	0.1	0.1	NUM
dti-1375	76	17	µm	µm	NOUN
dti-1375	76	18	)	)	PUNCT
dti-1375	76	19	,	,	PUNCT
dti-1375	76	20	17aag	17aag	NOUN
dti-1375	76	21	(	(	PUNCT
dti-1375	76	22	2.0	2.0	NUM
dti-1375	76	23	µm	µm	NOUN
dti-1375	76	24	)	)	PUNCT
dti-1375	76	25	or	or	CCONJ
dti-1375	76	26	their	their	PRON
dti-1375	76	27	combination	combination	NOUN
dti-1375	76	28	treatment	treatment	NOUN
dti-1375	76	29	,	,	PUNCT
dti-1375	76	30	cells	cell	NOUN
dti-1375	76	31	were	be	AUX
dti-1375	76	32	treated	treat	VERB
dti-1375	76	33	for	for	ADP
dti-1375	76	34	6	6	NUM
dti-1375	76	35	-	-	PUNCT
dti-1375	76	36	days	day	NOUN
dti-1375	76	37	,	,	PUNCT
dti-1375	76	38	stained	stain	VERB
dti-1375	76	39	with	with	ADP
dti-1375	76	40	x	x	NOUN
dti-1375	76	41	-	-	NOUN
dti-1375	76	42	gal	gal	ADJ
dti-1375	76	43	and	and	CCONJ
dti-1375	76	44	observed	observe	VERB
dti-1375	76	45	under	under	ADP
dti-1375	76	46	the	the	DET
dti-1375	76	47	microscope	microscope	NOUN
dti-1375	76	48	.	.	PUNCT
dti-1375	77	1	doxorubicin	doxorubicin	PROPN
dti-1375	77	2	treatment	treatment	NOUN
dti-1375	77	3	precisely	precisely	ADV
dti-1375	77	4	increased	increase	VERB
dti-1375	77	5	sa	sa	NOUN
dti-1375	77	6	-	-	PUNCT
dti-1375	77	7	β	β	NOUN
dti-1375	77	8	-	-	ADJ
dti-1375	77	9	gal	gal	ADJ
dti-1375	77	10	positive	positive	ADJ
dti-1375	77	11	cells	cell	NOUN
dti-1375	77	12	with	with	ADP
dti-1375	77	13	extended	extended	ADJ
dti-1375	77	14	cell	cell	NOUN
dti-1375	77	15	morphology	morphology	NOUN
dti-1375	77	16	(	(	PUNCT
dti-1375	77	17	35	35	NUM
dti-1375	77	18	%	%	NOUN
dti-1375	77	19	±	±	NUM
dti-1375	77	20	5	5	NUM
dti-1375	77	21	%	%	NOUN
dti-1375	77	22	,	,	PUNCT
dti-1375	77	23	p	p	NOUN
dti-1375	77	24	,	,	PUNCT
dti-1375	77	25	0.001	0.001	NUM
dti-1375	77	26	)	)	PUNCT
dti-1375	77	27	.	.	PUNCT
dti-1375	78	1	the	the	DET
dti-1375	78	2	17aag	17aag	ADJ
dti-1375	78	3	treatment	treatment	NOUN
dti-1375	78	4	showed	show	VERB
dti-1375	78	5	aspecific	aspecific	ADJ
dti-1375	78	6	β	β	ADJ
dti-1375	78	7	-	-	ADJ
dti-1375	78	8	gal	gal	ADJ
dti-1375	78	9	staining	staining	NOUN
dti-1375	78	10	,	,	PUNCT
dti-1375	78	11	which	which	PRON
dti-1375	78	12	did	do	AUX
dti-1375	78	13	not	not	PART
dti-1375	78	14	correlate	correlate	VERB
dti-1375	78	15	with	with	ADP
dti-1375	78	16	senescence	senescence	NOUN
dti-1375	78	17	morphology	morphology	NOUN
dti-1375	78	18	.	.	PUNCT
dti-1375	79	1	doxorubicin	doxorubicin	PROPN
dti-1375	79	2	and	and	CCONJ
dti-1375	79	3	17aag	17aag	NOUN
dti-1375	79	4	combination	combination	NOUN
dti-1375	79	5	treatment	treatment	NOUN
dti-1375	79	6	decreased	decrease	VERB
dti-1375	79	7	saβ	saβ	ADJ
dti-1375	79	8	-	-	PUNCT
dti-1375	79	9	gal	gal	ADJ
dti-1375	79	10	positive	positive	ADJ
dti-1375	79	11	cells	cell	NOUN
dti-1375	79	12	(	(	PUNCT
dti-1375	79	13	14	14	NUM
dti-1375	79	14	%	%	NOUN
dti-1375	79	15	±	±	NUM
dti-1375	79	16	3	3	NUM
dti-1375	79	17	%	%	NOUN
dti-1375	79	18	against	against	ADP
dti-1375	79	19	35	35	NUM
dti-1375	79	20	%	%	NOUN
dti-1375	79	21	±	±	NUM
dti-1375	79	22	5	5	NUM
dti-1375	79	23	%	%	NOUN
dti-1375	79	24	of	of	ADP
dti-1375	79	25	doxorubicin	doxorubicin	PROPN
dti-1375	79	26	)	)	PUNCT
dti-1375	79	27	,	,	PUNCT
dti-1375	79	28	thus	thus	ADV
dti-1375	79	29	,	,	PUNCT
dti-1375	79	30	suggested	suggest	VERB
dti-1375	79	31	impaired	impaired	ADJ
dti-1375	79	32	senescence	senescence	NOUN
dti-1375	79	33	response	response	NOUN
dti-1375	79	34	on	on	ADP
dti-1375	79	35	prolonged	prolonged	ADJ
dti-1375	79	36	hsp90	hsp90	ADJ
dti-1375	79	37	inhibition	inhibition	NOUN
dti-1375	79	38	(	(	PUNCT
dti-1375	79	39	fig	fig	NOUN
dti-1375	79	40	.	.	PUNCT
dti-1375	80	1	1a	1a	PROPN
dti-1375	80	2	and	and	CCONJ
dti-1375	80	3	1a1	1a1	NUM
dti-1375	80	4	,	,	PUNCT
dti-1375	80	5	p	p	NOUN
dti-1375	80	6	,	,	PUNCT
dti-1375	80	7	0.01	0.01	NUM
dti-1375	80	8	)	)	PUNCT
dti-1375	80	9	.	.	PUNCT
dti-1375	81	1	to	to	PART
dti-1375	81	2	understand	understand	VERB
dti-1375	81	3	the	the	DET
dti-1375	81	4	indistinctness	indistinctness	NOUN
dti-1375	81	5	in	in	ADP
dti-1375	81	6	β	β	ADJ
dti-1375	81	7	-	-	ADJ
dti-1375	81	8	gal	gal	ADJ
dti-1375	81	9	staining	staining	NOUN
dti-1375	81	10	of	of	ADP
dti-1375	81	11	cells	cell	NOUN
dti-1375	81	12	between	between	ADP
dti-1375	81	13	doxorubicin	doxorubicin	PROPN
dti-1375	81	14	and	and	CCONJ
dti-1375	81	15	17aag	17aag	NOUN
dti-1375	81	16	treatments	treatment	NOUN
dti-1375	81	17	,	,	PUNCT
dti-1375	81	18	live	live	ADJ
dti-1375	81	19	cell	cell	NOUN
dti-1375	81	20	morphology	morphology	NOUN
dti-1375	81	21	was	be	AUX
dti-1375	81	22	examined	examine	VERB
dti-1375	81	23	under	under	ADP
dti-1375	81	24	the	the	DET
dti-1375	81	25	microscope	microscope	NOUN
dti-1375	81	26	.	.	PUNCT
dti-1375	82	1	doxorubicin	doxorubicin	PROPN
dti-1375	82	2	treatment	treatment	NOUN
dti-1375	82	3	resulted	result	VERB
dti-1375	82	4	in	in	ADP
dti-1375	82	5	extended	extended	ADJ
dti-1375	82	6	cellular	cellular	ADJ
dti-1375	82	7	connections	connection	NOUN
dti-1375	82	8	along	along	ADP
dti-1375	82	9	with	with	ADP
dti-1375	82	10	increased	increase	VERB
dti-1375	82	11	nucleus	nucleus	NOUN
dti-1375	82	12	to	to	AUX
dti-1375	82	13	cytoplasm	cytoplasm	NOUN
dti-1375	82	14	ratio	ratio	NOUN
dti-1375	82	15	,	,	PUNCT
dti-1375	82	16	however	however	ADV
dti-1375	82	17	,	,	PUNCT
dti-1375	82	18	17aag	17aag	ADJ
dti-1375	82	19	treatment	treatment	NOUN
dti-1375	82	20	showed	show	VERB
dti-1375	82	21	loss	loss	NOUN
dti-1375	82	22	of	of	ADP
dti-1375	82	23	surface	surface	NOUN
dti-1375	82	24	contact	contact	NOUN
dti-1375	82	25	.	.	PUNCT
dti-1375	83	1	in	in	ADP
dti-1375	83	2	the	the	DET
dti-1375	83	3	combination	combination	NOUN
dti-1375	83	4	treatment	treatment	NOUN
dti-1375	83	5	,	,	PUNCT
dti-1375	83	6	a	a	DET
dti-1375	83	7	few	few	ADJ
dti-1375	83	8	cells	cell	NOUN
dti-1375	83	9	were	be	AUX
dti-1375	83	10	found	find	VERB
dti-1375	83	11	still	still	ADV
dti-1375	83	12	attached	attach	VERB
dti-1375	83	13	to	to	ADP
dti-1375	83	14	the	the	DET
dti-1375	83	15	substratum	substratum	NOUN
dti-1375	83	16	even	even	ADV
dti-1375	83	17	on	on	ADP
dti-1375	83	18	6	6	NUM
dti-1375	83	19	-	-	PUNCT
dti-1375	83	20	day	day	NOUN
dti-1375	83	21	long	long	ADJ
dti-1375	83	22	treatment	treatment	NOUN
dti-1375	83	23	(	(	PUNCT
dti-1375	83	24	suppl	suppl	PROPN
dti-1375	83	25	.	.	PUNCT
dti-1375	83	26	fig	fig	PROPN
dti-1375	83	27	.	.	PUNCT
dti-1375	84	1	1a	1a	NOUN
dti-1375	84	2	)	)	PUNCT
dti-1375	84	3	.	.	PUNCT
dti-1375	85	1	the	the	DET
dti-1375	85	2	adherent	adherent	ADJ
dti-1375	85	3	cells	cell	NOUN
dti-1375	85	4	thus	thus	ADV
dti-1375	85	5	can	can	AUX
dti-1375	85	6	be	be	AUX
dti-1375	85	7	related	relate	VERB
dti-1375	85	8	to	to	ADP
dti-1375	85	9	only	only	ADV
dti-1375	85	10	sa	sa	VERB
dti-1375	85	11	-	-	PUNCT
dti-1375	85	12	β	β	NOUN
dti-1375	85	13	-	-	ADJ
dti-1375	85	14	gal	gal	ADJ
dti-1375	85	15	positive	positive	ADJ
dti-1375	85	16	cells	cell	NOUN
dti-1375	85	17	.	.	PUNCT
dti-1375	86	1	the	the	DET
dti-1375	86	2	differential	differential	ADJ
dti-1375	86	3	senescence	senescence	NOUN
dti-1375	86	4	response	response	NOUN
dti-1375	86	5	to	to	ADP
dti-1375	86	6	different	different	ADJ
dti-1375	86	7	drugs	drug	NOUN
dti-1375	86	8	may	may	AUX
dti-1375	86	9	be	be	AUX
dti-1375	86	10	related	relate	VERB
dti-1375	86	11	to	to	ADP
dti-1375	86	12	survival	survival	NOUN
dti-1375	86	13	potential	potential	NOUN
dti-1375	86	14	of	of	ADP
dti-1375	86	15	cells	cell	NOUN
dti-1375	86	16	on	on	ADP
dti-1375	86	17	prolonged	prolonged	ADJ
dti-1375	86	18	treatments	treatment	NOUN
dti-1375	86	19	.	.	PUNCT
dti-1375	87	1	investigating	investigate	VERB
dti-1375	87	2	the	the	DET
dti-1375	87	3	dna	dna	PROPN
dti-1375	87	4	http://www.la-press.com	http://www.la-press.com	X
dti-1375	88	1	hsp90	hsp90	ADJ
dti-1375	88	2	inhibition	inhibition	NOUN
dti-1375	88	3	accelerates	accelerate	VERB
dti-1375	88	4	senescence	senescence	NOUN
dti-1375	88	5	drug	drug	NOUN
dti-1375	88	6	target	target	NOUN
dti-1375	88	7	insights	insight	NOUN
dti-1375	88	8	2012:6	2012:6	NUM
dti-1375	88	9	23	23	NUM
dti-1375	88	10	content	content	NOUN
dti-1375	88	11	of	of	ADP
dti-1375	88	12	cells	cell	NOUN
dti-1375	88	13	during	during	ADP
dti-1375	88	14	the	the	DET
dti-1375	88	15	treatments	treatment	NOUN
dti-1375	88	16	by	by	ADP
dti-1375	88	17	facs	fac	NOUN
dti-1375	88	18	analysis	analysis	NOUN
dti-1375	88	19	uncovered	uncover	VERB
dti-1375	88	20	that	that	SCONJ
dti-1375	88	21	doxorubicin	doxorubicin	PROPN
dti-1375	88	22	and	and	CCONJ
dti-1375	88	23	17aag	17aag	NOUN
dti-1375	88	24	treatments	treatment	NOUN
dti-1375	88	25	gradually	gradually	ADV
dti-1375	88	26	increased	increase	VERB
dti-1375	88	27	subg1	subg1	ADJ
dti-1375	88	28	population	population	NOUN
dti-1375	88	29	of	of	ADP
dti-1375	88	30	cells	cell	NOUN
dti-1375	88	31	.	.	PUNCT
dti-1375	89	1	interestingly	interestingly	ADV
dti-1375	89	2	,	,	PUNCT
dti-1375	89	3	the	the	DET
dti-1375	89	4	combination	combination	NOUN
dti-1375	89	5	treatment	treatment	NOUN
dti-1375	89	6	showed	show	VERB
dti-1375	89	7	precipitous	precipitous	ADJ
dti-1375	89	8	50	50	NUM
dti-1375	89	9	%	%	NOUN
dti-1375	89	10	increase	increase	NOUN
dti-1375	89	11	(	(	PUNCT
dti-1375	89	12	p	p	NOUN
dti-1375	89	13	,	,	PUNCT
dti-1375	89	14	0.001	0.001	NUM
dti-1375	89	15	)	)	PUNCT
dti-1375	89	16	in	in	ADP
dti-1375	89	17	subg1	subg1	ADJ
dti-1375	89	18	cells	cell	NOUN
dti-1375	89	19	as	as	ADV
dti-1375	89	20	early	early	ADV
dti-1375	89	21	as	as	ADP
dti-1375	89	22	in	in	ADP
dti-1375	89	23	3	3	NUM
dti-1375	89	24	-	-	PUNCT
dti-1375	89	25	days	day	NOUN
dti-1375	89	26	(	(	PUNCT
dti-1375	89	27	suppl	suppl	PROPN
dti-1375	89	28	.	.	PUNCT
dti-1375	89	29	fig	fig	PROPN
dti-1375	89	30	.	.	PUNCT
dti-1375	90	1	1b	1b	NUM
dti-1375	90	2	)	)	PUNCT
dti-1375	90	3	.	.	PUNCT
dti-1375	91	1	17aag	17aag	NOUN
dti-1375	91	2	and	and	CCONJ
dti-1375	91	3	its	its	PRON
dti-1375	91	4	combination	combination	NOUN
dti-1375	91	5	with	with	ADP
dti-1375	91	6	doxorubicin	doxorubicin	PROPN
dti-1375	91	7	induces	induce	VERB
dti-1375	91	8	stress	stress	ADJ
dti-1375	91	9	response	response	NOUN
dti-1375	91	10	tumor	tumor	NOUN
dti-1375	91	11	suppressors	suppressor	NOUN
dti-1375	91	12	play	play	VERB
dti-1375	91	13	a	a	DET
dti-1375	91	14	major	major	ADJ
dti-1375	91	15	role	role	NOUN
dti-1375	91	16	in	in	ADP
dti-1375	91	17	deciding	decide	VERB
dti-1375	91	18	the	the	DET
dti-1375	91	19	fate	fate	NOUN
dti-1375	91	20	of	of	ADP
dti-1375	91	21	cells	cell	NOUN
dti-1375	91	22	under	under	ADP
dti-1375	91	23	stress	stress	NOUN
dti-1375	91	24	conditions	condition	NOUN
dti-1375	91	25	.	.	PUNCT
dti-1375	92	1	to	to	PART
dti-1375	92	2	investigate	investigate	VERB
dti-1375	92	3	their	their	PRON
dti-1375	92	4	functional	functional	ADJ
dti-1375	92	5	role	role	NOUN
dti-1375	92	6	in	in	ADP
dti-1375	92	7	senescence	senescence	NOUN
dti-1375	92	8	,	,	PUNCT
dti-1375	92	9	the	the	DET
dti-1375	92	10	expression	expression	NOUN
dti-1375	92	11	levels	level	NOUN
dti-1375	92	12	of	of	ADP
dti-1375	92	13	p21cip	p21cip	PROPN
dti-1375	92	14	/	/	SYM
dti-1375	92	15	waf-1	waf-1	NUM
dti-1375	92	16	,	,	PUNCT
dti-1375	92	17	p16ink4a	p16ink4a	PROPN
dti-1375	92	18	and	and	CCONJ
dti-1375	92	19	p53	p53	NOUN
dti-1375	92	20	were	be	AUX
dti-1375	92	21	examined	examine	VERB
dti-1375	92	22	by	by	ADP
dti-1375	92	23	rt	rt	PROPN
dti-1375	92	24	-	-	PUNCT
dti-1375	92	25	pcr	pcr	PROPN
dti-1375	92	26	day	day	NOUN
dti-1375	92	27	1	1	NUM
dti-1375	92	28	tumor	tumor	NOUN
dti-1375	92	29	senescence	senescence	NOUN
dti-1375	92	30	6	6	NUM
dti-1375	92	31	(	(	PUNCT
dti-1375	92	32	%	%	NOUN
dti-1375	92	33	)	)	PUNCT
dti-1375	92	34	35	35	NUM
dti-1375	92	35	0	0	NUM
dti-1375	92	36	14	14	NUM
dti-1375	92	37	doxo	doxo	PROPN
dti-1375	92	38	17aag	17aag	PROPN
dti-1375	92	39	doxo	doxo	PROPN
dti-1375	92	40	+	+	CCONJ
dti-1375	92	41	17aag	17aag	NOUN
dti-1375	92	42	doxorubicin	doxorubicin	NOUN
dti-1375	93	1	+17aag	+17aag	PRON
dti-1375	94	1	p	p	NOUN
dti-1375	94	2	21	21	NUM
dti-1375	94	3	/g	/g	PUNCT
dti-1375	94	4	a	a	DET
dti-1375	94	5	p	p	X
dti-1375	94	6	d	d	X
dti-1375	94	7	h	h	NOUN
dti-1375	94	8	r	r	NOUN
dti-1375	94	9	at	at	ADP
dti-1375	94	10	io	io	X
dti-1375	94	11	0	0	NUM
dti-1375	94	12	control	control	NOUN
dti-1375	94	13	1	1	NUM
dti-1375	94	14	d	d	SYM
dti-1375	94	15	2	2	NUM
dti-1375	94	16	d	d	SYM
dti-1375	94	17	4	4	NUM
dti-1375	94	18	d	d	SYM
dti-1375	94	19	6	6	NUM
dti-1375	94	20	d	d	SYM
dti-1375	94	21	0.5	0.5	NUM
dti-1375	94	22	1.0	1.0	NUM
dti-1375	94	23	1.5	1.5	NUM
dti-1375	94	24	2.0	2.0	NUM
dti-1375	94	25	p	p	NOUN
dti-1375	94	26	16	16	NUM
dti-1375	94	27	/g	/g	PUNCT
dti-1375	94	28	a	a	DET
dti-1375	94	29	p	p	X
dti-1375	94	30	d	d	X
dti-1375	94	31	h	h	NOUN
dti-1375	94	32	r	r	NOUN
dti-1375	94	33	at	at	ADP
dti-1375	94	34	io	io	X
dti-1375	94	35	0	0	NUM
dti-1375	94	36	control	control	NOUN
dti-1375	94	37	1	1	NUM
dti-1375	94	38	d	d	SYM
dti-1375	94	39	2	2	NUM
dti-1375	94	40	d	d	SYM
dti-1375	94	41	4	4	NUM
dti-1375	94	42	d	d	SYM
dti-1375	94	43	6	6	NUM
dti-1375	94	44	d	d	SYM
dti-1375	94	45	0.5	0.5	NUM
dti-1375	94	46	1.0	1.0	NUM
dti-1375	94	47	1.5	1.5	NUM
dti-1375	94	48	2.0	2.0	NUM
dti-1375	94	49	p	p	NOUN
dti-1375	94	50	53	53	NUM
dti-1375	94	51	/g	/g	PUNCT
dti-1375	94	52	a	a	DET
dti-1375	94	53	p	p	X
dti-1375	94	54	d	d	X
dti-1375	94	55	h	h	NOUN
dti-1375	94	56	r	r	NOUN
dti-1375	94	57	at	at	ADP
dti-1375	94	58	io	io	X
dti-1375	94	59	0	0	NUM
dti-1375	94	60	control	control	NOUN
dti-1375	94	61	1	1	NUM
dti-1375	94	62	d	d	SYM
dti-1375	94	63	2	2	NUM
dti-1375	94	64	d	d	SYM
dti-1375	94	65	4	4	NUM
dti-1375	94	66	d	d	SYM
dti-1375	94	67	6	6	NUM
dti-1375	94	68	d	d	SYM
dti-1375	94	69	0.5	0.5	NUM
dti-1375	94	70	1.0	1.0	NUM
dti-1375	94	71	1.5	1.5	NUM
dti-1375	94	72	2.0	2.0	NUM
dti-1375	94	73	h	h	NOUN
dti-1375	94	74	sp	sp	ADP
dti-1375	94	75	27	27	NUM
dti-1375	94	76	/g	/g	PUNCT
dti-1375	94	77	a	a	DET
dti-1375	94	78	p	p	X
dti-1375	94	79	d	d	X
dti-1375	94	80	h	h	NOUN
dti-1375	94	81	r	r	NOUN
dti-1375	94	82	at	at	ADP
dti-1375	94	83	io	io	X
dti-1375	94	84	0	0	NUM
dti-1375	94	85	control	control	NOUN
dti-1375	94	86	1	1	NUM
dti-1375	94	87	d	d	SYM
dti-1375	94	88	2	2	NUM
dti-1375	94	89	d	d	SYM
dti-1375	94	90	4	4	NUM
dti-1375	94	91	d	d	SYM
dti-1375	94	92	6	6	NUM
dti-1375	94	93	d	d	SYM
dti-1375	94	94	0.5	0.5	NUM
dti-1375	94	95	1.0	1.0	NUM
dti-1375	94	96	1.5	1.5	NUM
dti-1375	94	97	2.0	2.0	NUM
dti-1375	94	98	h	h	NOUN
dti-1375	94	99	sp	sp	ADP
dti-1375	94	100	70	70	NUM
dti-1375	94	101	/g	/g	PUNCT
dti-1375	94	102	a	a	DET
dti-1375	94	103	p	p	X
dti-1375	94	104	d	d	X
dti-1375	94	105	h	h	NOUN
dti-1375	94	106	r	r	NOUN
dti-1375	94	107	at	at	ADP
dti-1375	94	108	io	io	X
dti-1375	94	109	0	0	NUM
dti-1375	94	110	control	control	NOUN
dti-1375	94	111	1	1	NUM
dti-1375	94	112	d	d	SYM
dti-1375	94	113	2	2	NUM
dti-1375	94	114	d	d	SYM
dti-1375	94	115	4	4	NUM
dti-1375	94	116	d	d	SYM
dti-1375	94	117	6	6	NUM
dti-1375	94	118	d	d	SYM
dti-1375	94	119	0.5	0.5	NUM
dti-1375	94	120	1.0	1.0	NUM
dti-1375	94	121	1.5	1.5	NUM
dti-1375	94	122	2.0	2.0	NUM
dti-1375	94	123	h	h	NOUN
dti-1375	94	124	sp	sp	ADP
dti-1375	94	125	90	90	NUM
dti-1375	94	126	/g	/g	PUNCT
dti-1375	94	127	a	a	DET
dti-1375	94	128	p	p	X
dti-1375	94	129	d	d	X
dti-1375	94	130	h	h	NOUN
dti-1375	94	131	r	r	NOUN
dti-1375	94	132	at	at	ADP
dti-1375	94	133	io	io	X
dti-1375	94	134	0	0	NUM
dti-1375	94	135	control	control	NOUN
dti-1375	94	136	1	1	NUM
dti-1375	94	137	d	d	SYM
dti-1375	94	138	2	2	NUM
dti-1375	94	139	d	d	SYM
dti-1375	94	140	4	4	NUM
dti-1375	94	141	d	d	SYM
dti-1375	94	142	6	6	NUM
dti-1375	94	143	d	d	SYM
dti-1375	94	144	0.5	0.5	NUM
dti-1375	94	145	1.0	1.0	NUM
dti-1375	94	146	1.5	1.5	NUM
dti-1375	94	147	2.0	2.0	NUM
dti-1375	94	148	doxorubicin	doxorubicin	PROPN
dti-1375	94	149	p	p	PROPN
dti-1375	94	150	21	21	NUM
dti-1375	94	151	/g	/g	PUNCT
dti-1375	94	152	a	a	DET
dti-1375	94	153	p	p	X
dti-1375	95	1	d	d	X
dti-1375	95	2	h	h	NOUN
dti-1375	95	3	r	r	NOUN
dti-1375	95	4	at	at	ADP
dti-1375	95	5	io	io	X
dti-1375	95	6	17aag	17aag	NOUN
dti-1375	95	7	0	0	PUNCT
dti-1375	96	1	control1	control1	NOUN
dti-1375	97	1	d	d	ADP
dti-1375	97	2	2	2	NUM
dti-1375	97	3	d	d	SYM
dti-1375	97	4	4	4	NUM
dti-1375	97	5	d	d	SYM
dti-1375	97	6	6	6	NUM
dti-1375	97	7	d	d	SYM
dti-1375	97	8	1	1	NUM
dti-1375	97	9	d	d	SYM
dti-1375	97	10	2	2	NUM
dti-1375	97	11	d	d	SYM
dti-1375	97	12	4	4	NUM
dti-1375	97	13	d	d	SYM
dti-1375	97	14	6	6	NUM
dti-1375	97	15	d	d	SYM
dti-1375	97	16	0.5	0.5	NUM
dti-1375	97	17	1.0	1.0	NUM
dti-1375	97	18	1.5	1.5	NUM
dti-1375	97	19	2.0	2.0	NUM
dti-1375	97	20	2.5	2.5	NUM
dti-1375	97	21	doxorubicin	doxorubicin	PROPN
dti-1375	97	22	p	p	PROPN
dti-1375	97	23	16	16	NUM
dti-1375	97	24	/g	/g	PUNCT
dti-1375	97	25	a	a	DET
dti-1375	97	26	p	p	X
dti-1375	98	1	d	d	X
dti-1375	98	2	h	h	NOUN
dti-1375	98	3	r	r	NOUN
dti-1375	98	4	at	at	ADP
dti-1375	98	5	io	io	X
dti-1375	98	6	17aag	17aag	NOUN
dti-1375	98	7	0	0	PUNCT
dti-1375	99	1	control1	control1	NOUN
dti-1375	100	1	d	d	ADP
dti-1375	100	2	2	2	NUM
dti-1375	100	3	d	d	SYM
dti-1375	100	4	4	4	NUM
dti-1375	100	5	d	d	SYM
dti-1375	100	6	6	6	NUM
dti-1375	100	7	d	d	SYM
dti-1375	100	8	1	1	NUM
dti-1375	100	9	d	d	SYM
dti-1375	100	10	2	2	NUM
dti-1375	100	11	d	d	SYM
dti-1375	100	12	4	4	NUM
dti-1375	100	13	d	d	SYM
dti-1375	100	14	6	6	NUM
dti-1375	100	15	d	d	SYM
dti-1375	100	16	0.5	0.5	NUM
dti-1375	100	17	1.0	1.0	NUM
dti-1375	100	18	1.5	1.5	NUM
dti-1375	100	19	2.0	2.0	NUM
dti-1375	100	20	2.5	2.5	NUM
dti-1375	100	21	doxorubicin	doxorubicin	PROPN
dti-1375	100	22	p	p	PROPN
dti-1375	100	23	16	16	NUM
dti-1375	100	24	/g	/g	PUNCT
dti-1375	100	25	a	a	DET
dti-1375	100	26	p	p	X
dti-1375	101	1	d	d	X
dti-1375	101	2	h	h	NOUN
dti-1375	101	3	r	r	NOUN
dti-1375	101	4	at	at	ADP
dti-1375	101	5	io	io	X
dti-1375	101	6	17aag	17aag	NOUN
dti-1375	101	7	0	0	PUNCT
dti-1375	102	1	control1	control1	NOUN
dti-1375	102	2	d	d	ADP
dti-1375	102	3	2	2	NUM
dti-1375	102	4	d	d	SYM
dti-1375	102	5	4	4	NUM
dti-1375	102	6	d	d	SYM
dti-1375	102	7	6	6	NUM
dti-1375	102	8	d	d	SYM
dti-1375	102	9	1	1	NUM
dti-1375	102	10	d	d	SYM
dti-1375	102	11	2	2	NUM
dti-1375	102	12	d	d	SYM
dti-1375	102	13	4	4	NUM
dti-1375	102	14	d	d	SYM
dti-1375	102	15	6	6	NUM
dti-1375	102	16	d	d	SYM
dti-1375	102	17	0.5	0.5	NUM
dti-1375	102	18	1.0	1.0	NUM
dti-1375	102	19	1.5	1.5	NUM
dti-1375	102	20	2.0	2.0	NUM
dti-1375	102	21	2.5	2.5	NUM
dti-1375	102	22	doxorubicin	doxorubicin	PROPN
dti-1375	102	23	h	h	NOUN
dti-1375	102	24	sp	sp	ADP
dti-1375	102	25	27	27	NUM
dti-1375	102	26	/g	/g	PUNCT
dti-1375	102	27	a	a	DET
dti-1375	102	28	p	p	X
dti-1375	103	1	d	d	X
dti-1375	103	2	h	h	NOUN
dti-1375	103	3	r	r	NOUN
dti-1375	103	4	at	at	ADP
dti-1375	103	5	io	io	X
dti-1375	103	6	17aag	17aag	NOUN
dti-1375	103	7	0	0	PUNCT
dti-1375	104	1	control1	control1	NOUN
dti-1375	104	2	d	d	ADP
dti-1375	104	3	2	2	NUM
dti-1375	104	4	d	d	SYM
dti-1375	104	5	4	4	NUM
dti-1375	104	6	d	d	SYM
dti-1375	104	7	6	6	NUM
dti-1375	104	8	d	d	SYM
dti-1375	104	9	1	1	NUM
dti-1375	104	10	d	d	SYM
dti-1375	104	11	2	2	NUM
dti-1375	104	12	d	d	SYM
dti-1375	104	13	4	4	NUM
dti-1375	104	14	d	d	SYM
dti-1375	104	15	6	6	NUM
dti-1375	104	16	d	d	SYM
dti-1375	104	17	0.5	0.5	NUM
dti-1375	104	18	1.0	1.0	NUM
dti-1375	104	19	1.5	1.5	NUM
dti-1375	104	20	2.0	2.0	NUM
dti-1375	104	21	2.5	2.5	NUM
dti-1375	104	22	doxorubicin	doxorubicin	PROPN
dti-1375	104	23	h	h	NOUN
dti-1375	104	24	sp	sp	ADP
dti-1375	104	25	70	70	NUM
dti-1375	104	26	/g	/g	PUNCT
dti-1375	104	27	a	a	DET
dti-1375	104	28	p	p	X
dti-1375	104	29	d	d	X
dti-1375	104	30	h	h	NOUN
dti-1375	104	31	r	r	NOUN
dti-1375	104	32	at	at	ADP
dti-1375	104	33	io	io	X
dti-1375	104	34	17aag	17aag	NOUN
dti-1375	104	35	0	0	PUNCT
dti-1375	105	1	control1	control1	NOUN
dti-1375	105	2	d	d	ADP
dti-1375	105	3	2	2	NUM
dti-1375	105	4	d	d	SYM
dti-1375	105	5	4	4	NUM
dti-1375	105	6	d	d	SYM
dti-1375	105	7	6	6	NUM
dti-1375	105	8	d	d	SYM
dti-1375	105	9	1	1	NUM
dti-1375	105	10	d	d	SYM
dti-1375	105	11	2	2	NUM
dti-1375	105	12	d	d	SYM
dti-1375	105	13	4	4	NUM
dti-1375	105	14	d	d	SYM
dti-1375	105	15	6	6	NUM
dti-1375	105	16	d	d	SYM
dti-1375	105	17	0.5	0.5	NUM
dti-1375	105	18	1.0	1.0	NUM
dti-1375	105	19	1.5	1.5	NUM
dti-1375	105	20	2.0	2.0	NUM
dti-1375	105	21	2.5	2.5	NUM
dti-1375	105	22	doxorubicin	doxorubicin	PROPN
dti-1375	105	23	h	h	NOUN
dti-1375	105	24	sp	sp	ADP
dti-1375	105	25	90	90	NUM
dti-1375	105	26	/g	/g	PUNCT
dti-1375	105	27	a	a	DET
dti-1375	105	28	p	p	X
dti-1375	106	1	d	d	X
dti-1375	106	2	h	h	NOUN
dti-1375	106	3	r	r	NOUN
dti-1375	106	4	at	at	ADP
dti-1375	106	5	io	io	X
dti-1375	106	6	17aag	17aag	NOUN
dti-1375	106	7	0	0	PUNCT
dti-1375	107	1	control1	control1	NOUN
dti-1375	108	1	d	d	ADP
dti-1375	108	2	2	2	NUM
dti-1375	108	3	d	d	SYM
dti-1375	108	4	4	4	NUM
dti-1375	108	5	d	d	SYM
dti-1375	108	6	6	6	NUM
dti-1375	108	7	d	d	SYM
dti-1375	108	8	1	1	NUM
dti-1375	108	9	d	d	SYM
dti-1375	108	10	2	2	NUM
dti-1375	108	11	d	d	SYM
dti-1375	108	12	4	4	NUM
dti-1375	108	13	d	d	SYM
dti-1375	108	14	6	6	NUM
dti-1375	108	15	d	d	SYM
dti-1375	108	16	0.5	0.5	NUM
dti-1375	108	17	1.0	1.0	NUM
dti-1375	108	18	1.5	1.5	NUM
dti-1375	108	19	2.0	2.0	NUM
dti-1375	108	20	2.5	2.5	NUM
dti-1375	108	21	days	day	NOUN
dti-1375	108	22	hsp27	hsp27	PROPN
dti-1375	108	23	hsp70	hsp70	PROPN
dti-1375	108	24	hsp90	hsp90	PROPN
dti-1375	108	25	gapdh	gapdh	NOUN
dti-1375	108	26	p53	p53	NOUN
dti-1375	108	27	p21	p21	NOUN
dti-1375	108	28	p16	p16	NOUN
dti-1375	108	29	doxorubicin	doxorubicin	PROPN
dti-1375	108	30	con	con	PROPN
dti-1375	108	31	1	1	NUM
dti-1375	108	32	2	2	NUM
dti-1375	108	33	4	4	NUM
dti-1375	108	34	6	6	NUM
dti-1375	108	35	1	1	NUM
dti-1375	108	36	2	2	NUM
dti-1375	108	37	4	4	NUM
dti-1375	108	38	6	6	NUM
dti-1375	108	39	1	1	NUM
dti-1375	108	40	2	2	NUM
dti-1375	108	41	4	4	NUM
dti-1375	108	42	6	6	NUM
dti-1375	108	43	17aag	17aag	NOUN
dti-1375	108	44	doxo	doxo	NOUN
dti-1375	108	45	+	+	CCONJ
dti-1375	108	46	17aag	17aag	NOUN
dti-1375	108	47	doxorubicin	doxorubicin	PROPN
dti-1375	108	48	cont	cont	NOUN
dti-1375	108	49	1	1	NUM
dti-1375	108	50	2	2	NUM
dti-1375	108	51	4	4	NUM
dti-1375	108	52	6	6	NUM
dti-1375	108	53	1	1	NUM
dti-1375	108	54	2	2	NUM
dti-1375	108	55	4	4	NUM
dti-1375	108	56	6	6	NUM
dti-1375	108	57	1	1	NUM
dti-1375	108	58	2	2	NUM
dti-1375	108	59	4	4	NUM
dti-1375	108	60	6	6	NUM
dti-1375	108	61	days	day	NOUN
dti-1375	108	62	cdk1	cdk1	PROPN
dti-1375	108	63	cdk2	cdk2	PROPN
dti-1375	108	64	cdk6	cdk6	PROPN
dti-1375	108	65	hsp27	hsp27	PROPN
dti-1375	108	66	hsp70	hsp70	PROPN
dti-1375	108	67	hsp90	hsp90	VERB
dti-1375	108	68	akt	akt	PROPN
dti-1375	108	69	erk1	erk1	PROPN
dti-1375	108	70	gapdh	gapdh	NOUN
dti-1375	108	71	p	p	PROPN
dti-1375	108	72	-	-	PUNCT
dti-1375	108	73	akt	akt	PROPN
dti-1375	108	74	(	(	PUNCT
dti-1375	108	75	ser	ser	NOUN
dti-1375	108	76	473	473	NUM
dti-1375	108	77	)	)	PUNCT
dti-1375	108	78	p	p	PROPN
dti-1375	108	79	-	-	PUNCT
dti-1375	108	80	erk	erk	NOUN
dti-1375	108	81	(	(	PUNCT
dti-1375	108	82	thr	thr	PROPN
dti-1375	108	83	202	202	NUM
dti-1375	108	84	)	)	PUNCT
dti-1375	108	85	p53	p53	NOUN
dti-1375	108	86	p21	p21	PROPN
dti-1375	109	1	c	c	PROPN
dti-1375	109	2	el	el	PROPN
dti-1375	109	3	l	l	PROPN
dti-1375	109	4	c	c	X
dti-1375	109	5	yc	yc	X
dti-1375	109	6	le	le	X
dti-1375	109	7	r	r	PROPN
dti-1375	109	8	eg	eg	PROPN
dti-1375	109	9	ul	ul	INTJ
dti-1375	109	10	at	at	ADP
dti-1375	109	11	or	or	CCONJ
dti-1375	109	12	s	s	PRON
dti-1375	109	13	h	h	NOUN
dti-1375	109	14	sp	sp	ADP
dti-1375	109	15	s	s	NOUN
dti-1375	109	16	s	s	VERB
dti-1375	109	17	ig	ig	NOUN
dti-1375	109	18	na	na	NOUN
dti-1375	109	19	lin	lin	PROPN
dti-1375	109	20	g	g	PROPN
dti-1375	109	21	m	m	PROPN
dti-1375	109	22	ol	ol	PROPN
dti-1375	109	23	ec	ec	PROPN
dti-1375	109	24	ul	ul	PROPN
dti-1375	109	25	es	es	PROPN
dti-1375	109	26	17aag	17aag	PROPN
dti-1375	109	27	doxo	doxo	PROPN
dti-1375	109	28	+	+	CCONJ
dti-1375	109	29	17aag	17aag	PROPN
dti-1375	109	30	control	control	NOUN
dti-1375	109	31	doxorubicin	doxorubicin	PROPN
dti-1375	109	32	17aag	17aag	PROPN
dti-1375	110	1	6da	6da	PROPN
dti-1375	110	2	ys	ys	PROPN
dti-1375	110	3	doxorubicin	doxorubicin	PROPN
dti-1375	110	4	+	+	CCONJ
dti-1375	110	5	17aag	17aag	VERB
dti-1375	110	6	a	a	DET
dti-1375	110	7	b	b	NOUN
dti-1375	110	8	a1	a1	NOUN
dti-1375	110	9	c	c	PROPN
dti-1375	110	10	b1	b1	NOUN
dti-1375	110	11	b2	b2	NOUN
dti-1375	110	12	figure	figure	NOUN
dti-1375	110	13	1	1	NUM
dti-1375	110	14	.	.	PUNCT
dti-1375	110	15	effect	effect	NOUN
dti-1375	110	16	of	of	ADP
dti-1375	110	17	doxorubicin	doxorubicin	PROPN
dti-1375	110	18	,	,	PUNCT
dti-1375	110	19	17aag	17aag	NOUN
dti-1375	110	20	and	and	CCONJ
dti-1375	110	21	their	their	PRON
dti-1375	110	22	combination	combination	NOUN
dti-1375	110	23	treatments	treatment	NOUN
dti-1375	110	24	on	on	ADP
dti-1375	110	25	imr-32	imr-32	NOUN
dti-1375	110	26	neuroblastoma	neuroblastoma	ADJ
dti-1375	110	27	cells	cell	NOUN
dti-1375	110	28	.	.	PUNCT
dti-1375	111	1	(	(	PUNCT
dti-1375	111	2	a	a	X
dti-1375	111	3	)	)	PUNCT
dti-1375	111	4	sa	sa	PROPN
dti-1375	111	5	-	-	PUNCT
dti-1375	111	6	β	β	NOUN
dti-1375	111	7	-	-	ADJ
dti-1375	111	8	gal	gal	ADJ
dti-1375	111	9	staining	staining	NOUN
dti-1375	111	10	of	of	ADP
dti-1375	111	11	control	control	NOUN
dti-1375	111	12	and	and	CCONJ
dti-1375	111	13	6	6	NUM
dti-1375	111	14	-	-	PUNCT
dti-1375	111	15	day	day	NOUN
dti-1375	111	16	drug	drug	NOUN
dti-1375	111	17	treated	treat	VERB
dti-1375	111	18	cells	cell	NOUN
dti-1375	111	19	.	.	PUNCT
dti-1375	112	1	the	the	DET
dti-1375	112	2	images	image	NOUN
dti-1375	112	3	were	be	AUX
dti-1375	112	4	captured	capture	VERB
dti-1375	112	5	at	at	ADP
dti-1375	112	6	20x	20x	NOUN
dti-1375	112	7	magnification	magnification	NOUN
dti-1375	112	8	(	(	PUNCT
dti-1375	112	9	axiovert	axiovert	NOUN
dti-1375	112	10	200	200	NUM
dti-1375	112	11	,	,	PUNCT
dti-1375	112	12	carl	carl	PROPN
dti-1375	112	13	zeiss	zeiss	PROPN
dti-1375	112	14	)	)	PUNCT
dti-1375	112	15	.	.	PUNCT
dti-1375	113	1	(	(	PUNCT
dti-1375	113	2	a1	a1	NOUN
dti-1375	113	3	)	)	PUNCT
dti-1375	113	4	statistical	statistical	ADJ
dti-1375	113	5	representation	representation	NOUN
dti-1375	113	6	of	of	ADP
dti-1375	113	7	individual	individual	ADJ
dti-1375	113	8	and	and	CCONJ
dti-1375	113	9	combination	combination	NOUN
dti-1375	113	10	drug	drug	NOUN
dti-1375	113	11	treatments	treatment	NOUN
dti-1375	113	12	induced	induce	VERB
dti-1375	113	13	percent	percent	NOUN
dti-1375	113	14	sa	sa	PROPN
dti-1375	113	15	-	-	PUNCT
dti-1375	113	16	β	β	NOUN
dti-1375	113	17	-	-	ADJ
dti-1375	113	18	gal	gal	ADJ
dti-1375	113	19	positive	positive	ADJ
dti-1375	113	20	cells	cell	NOUN
dti-1375	113	21	.	.	PUNCT
dti-1375	114	1	(	(	PUNCT
dti-1375	114	2	b	b	X
dti-1375	114	3	)	)	PUNCT
dti-1375	114	4	rt	rt	ADJ
dti-1375	114	5	-	-	PUNCT
dti-1375	114	6	pcr	pcr	NOUN
dti-1375	114	7	analysis	analysis	NOUN
dti-1375	114	8	of	of	ADP
dti-1375	114	9	cell	cell	NOUN
dti-1375	114	10	cycle	cycle	NOUN
dti-1375	114	11	regulators	regulator	NOUN
dti-1375	114	12	and	and	CCONJ
dti-1375	114	13	heat	heat	NOUN
dti-1375	114	14	shock	shock	NOUN
dti-1375	114	15	genes	gene	NOUN
dti-1375	114	16	on	on	ADP
dti-1375	114	17	the	the	DET
dti-1375	114	18	onset	onset	NOUN
dti-1375	114	19	of	of	ADP
dti-1375	114	20	stress	stress	NOUN
dti-1375	114	21	induced	induce	VERB
dti-1375	114	22	cellular	cellular	ADJ
dti-1375	114	23	senescence	senescence	NOUN
dti-1375	114	24	.	.	PUNCT
dti-1375	115	1	(	(	PUNCT
dti-1375	115	2	b1	b1	NOUN
dti-1375	115	3	and	and	CCONJ
dti-1375	115	4	b2	b2	NOUN
dti-1375	115	5	)	)	PUNCT
dti-1375	115	6	gene	gene	NOUN
dti-1375	115	7	expression	expression	NOUN
dti-1375	115	8	data	datum	NOUN
dti-1375	115	9	was	be	AUX
dti-1375	115	10	used	use	VERB
dti-1375	115	11	to	to	PART
dti-1375	115	12	calculate	calculate	VERB
dti-1375	115	13	the	the	DET
dti-1375	115	14	expression	expression	NOUN
dti-1375	115	15	ratios	ratio	NOUN
dti-1375	115	16	in	in	ADP
dti-1375	115	17	reference	reference	NOUN
dti-1375	115	18	to	to	ADP
dti-1375	115	19	gapdh	gapdh	NOUN
dti-1375	115	20	.	.	PUNCT
dti-1375	116	1	(	(	PUNCT
dti-1375	116	2	c	c	X
dti-1375	116	3	)	)	PUNCT
dti-1375	116	4	immunoblot	immunoblot	VERB
dti-1375	116	5	analysis	analysis	NOUN
dti-1375	116	6	of	of	ADP
dti-1375	116	7	proteins	protein	NOUN
dti-1375	116	8	from	from	ADP
dti-1375	116	9	cell	cell	NOUN
dti-1375	116	10	cycle	cycle	NOUN
dti-1375	116	11	,	,	PUNCT
dti-1375	116	12	hsps	hsps	NOUN
dti-1375	116	13	and	and	CCONJ
dti-1375	116	14	signal	signal	ADJ
dti-1375	116	15	transduction	transduction	NOUN
dti-1375	116	16	.	.	PUNCT
dti-1375	117	1	http://www.la-press.com	http://www.la-press.com	X
dti-1375	118	1	sarangi	sarangi	PROPN
dti-1375	118	2	et	et	PROPN
dti-1375	118	3	al	al	PROPN
dti-1375	118	4	24	24	NUM
dti-1375	118	5	drug	drug	NOUN
dti-1375	118	6	target	target	NOUN
dti-1375	118	7	insights	insight	NOUN
dti-1375	118	8	2012:6	2012:6	NUM
dti-1375	118	9	analyses	analysis	NOUN
dti-1375	118	10	at	at	ADP
dti-1375	118	11	2-	2-	PROPN
dti-1375	118	12	,	,	PUNCT
dti-1375	118	13	4and	4and	NOUN
dti-1375	118	14	6	6	NUM
dti-1375	118	15	-	-	PUNCT
dti-1375	118	16	day	day	NOUN
dti-1375	118	17	post	post	NOUN
dti-1375	118	18	-	-	NOUN
dti-1375	118	19	treatments	treatment	NOUN
dti-1375	118	20	.	.	PUNCT
dti-1375	119	1	the	the	DET
dti-1375	119	2	individual	individual	ADJ
dti-1375	119	3	treatments	treatment	NOUN
dti-1375	119	4	showed	show	VERB
dti-1375	119	5	a	a	DET
dti-1375	119	6	gradual	gradual	ADJ
dti-1375	119	7	decrease	decrease	NOUN
dti-1375	119	8	in	in	ADP
dti-1375	119	9	p21cip/	p21cip/	NOUN
dti-1375	119	10	waf-1	waf-1	ADP
dti-1375	119	11	along	along	ADP
dti-1375	119	12	with	with	ADP
dti-1375	119	13	the	the	DET
dti-1375	119	14	time	time	NOUN
dti-1375	119	15	of	of	ADP
dti-1375	119	16	treatment	treatment	NOUN
dti-1375	119	17	.	.	PUNCT
dti-1375	120	1	the	the	DET
dti-1375	120	2	combination	combination	NOUN
dti-1375	120	3	treatment	treatment	NOUN
dti-1375	120	4	though	though	ADV
dti-1375	120	5	showed	show	VERB
dti-1375	120	6	an	an	DET
dti-1375	120	7	initial	initial	ADJ
dti-1375	120	8	decrease	decrease	NOUN
dti-1375	120	9	in	in	ADP
dti-1375	120	10	2	2	NUM
dti-1375	120	11	-	-	PUNCT
dti-1375	120	12	day	day	NOUN
dti-1375	120	13	treatment	treatment	NOUN
dti-1375	120	14	,	,	PUNCT
dti-1375	120	15	and	and	CCONJ
dti-1375	120	16	a	a	DET
dti-1375	120	17	significant	significant	ADJ
dti-1375	120	18	increase	increase	NOUN
dti-1375	120	19	was	be	AUX
dti-1375	120	20	observed	observe	VERB
dti-1375	120	21	by	by	ADP
dti-1375	120	22	a	a	DET
dti-1375	120	23	6	6	NUM
dti-1375	120	24	-	-	PUNCT
dti-1375	120	25	day	day	NOUN
dti-1375	120	26	treatment	treatment	NOUN
dti-1375	120	27	.	.	PUNCT
dti-1375	121	1	correlating	correlate	VERB
dti-1375	121	2	with	with	ADP
dti-1375	121	3	p21cip	p21cip	PROPN
dti-1375	121	4	/	/	SYM
dti-1375	121	5	waf-1	waf-1	PUNCT
dti-1375	121	6	there	there	PRON
dti-1375	121	7	was	be	VERB
dti-1375	121	8	an	an	DET
dti-1375	121	9	increase	increase	NOUN
dti-1375	121	10	in	in	ADP
dti-1375	121	11	p53	p53	NOUN
dti-1375	121	12	expression	expression	NOUN
dti-1375	121	13	in	in	ADP
dti-1375	121	14	17aag	17aag	NOUN
dti-1375	121	15	(	(	PUNCT
dti-1375	121	16	up	up	ADP
dti-1375	121	17	to	to	PART
dti-1375	121	18	4	4	NUM
dti-1375	121	19	-	-	PUNCT
dti-1375	121	20	day	day	NOUN
dti-1375	121	21	)	)	PUNCT
dti-1375	121	22	and	and	CCONJ
dti-1375	121	23	its	its	PRON
dti-1375	121	24	combination	combination	NOUN
dti-1375	121	25	with	with	ADP
dti-1375	121	26	doxorubicin	doxorubicin	PROPN
dti-1375	121	27	(	(	PUNCT
dti-1375	121	28	by	by	ADP
dti-1375	121	29	1	1	NUM
dti-1375	121	30	-	-	PUNCT
dti-1375	121	31	day	day	NOUN
dti-1375	121	32	)	)	PUNCT
dti-1375	121	33	corresponding	correspond	VERB
dti-1375	121	34	to	to	ADP
dti-1375	121	35	activation	activation	NOUN
dti-1375	121	36	of	of	ADP
dti-1375	121	37	cellular	cellular	ADJ
dti-1375	121	38	stress	stress	NOUN
dti-1375	121	39	response	response	NOUN
dti-1375	121	40	.	.	PUNCT
dti-1375	122	1	the	the	DET
dti-1375	122	2	doxorubicin	doxorubicin	PROPN
dti-1375	122	3	induced	induce	VERB
dti-1375	122	4	p53	p53	NOUN
dti-1375	122	5	,	,	PUNCT
dti-1375	122	6	however	however	ADV
dti-1375	122	7	,	,	PUNCT
dti-1375	122	8	may	may	AUX
dti-1375	122	9	be	be	AUX
dti-1375	122	10	related	relate	VERB
dti-1375	122	11	to	to	ADP
dti-1375	122	12	dna	dna	PROPN
dti-1375	122	13	damage	damage	NOUN
dti-1375	122	14	response	response	NOUN
dti-1375	122	15	.	.	PUNCT
dti-1375	123	1	additionally	additionally	ADV
dti-1375	123	2	,	,	PUNCT
dti-1375	123	3	increased	increase	VERB
dti-1375	123	4	expression	expression	NOUN
dti-1375	123	5	of	of	ADP
dti-1375	123	6	stress	stress	ADJ
dti-1375	123	7	proteins	protein	NOUN
dti-1375	123	8	,	,	PUNCT
dti-1375	123	9	hsp27	hsp27	PROPN
dti-1375	123	10	,	,	PUNCT
dti-1375	123	11	hsp70	hsp70	NOUN
dti-1375	123	12	and	and	CCONJ
dti-1375	123	13	hsp90	hsp90	VERB
dti-1375	123	14	upon	upon	SCONJ
dti-1375	123	15	17aag	17aag	NOUN
dti-1375	123	16	and	and	CCONJ
dti-1375	123	17	its	its	PRON
dti-1375	123	18	combination	combination	NOUN
dti-1375	123	19	with	with	ADP
dti-1375	123	20	doxorubicin	doxorubicin	PROPN
dti-1375	123	21	treatments	treatment	NOUN
dti-1375	123	22	further	far	ADV
dti-1375	123	23	confirm	confirm	VERB
dti-1375	123	24	activation	activation	NOUN
dti-1375	123	25	of	of	ADP
dti-1375	123	26	stress	stress	NOUN
dti-1375	123	27	response	response	NOUN
dti-1375	123	28	(	(	PUNCT
dti-1375	123	29	fig	fig	NOUN
dti-1375	123	30	.	.	PUNCT
dti-1375	123	31	1b	1b	NUM
dti-1375	123	32	)	)	PUNCT
dti-1375	123	33	.	.	PUNCT
dti-1375	124	1	the	the	DET
dti-1375	124	2	ratio	ratio	NOUN
dti-1375	124	3	between	between	ADP
dti-1375	124	4	each	each	DET
dti-1375	124	5	target	target	NOUN
dti-1375	124	6	gene	gene	NOUN
dti-1375	124	7	and	and	CCONJ
dti-1375	124	8	gapdh	gapdh	NOUN
dti-1375	124	9	expression	expression	NOUN
dti-1375	124	10	was	be	AUX
dti-1375	124	11	calculated	calculate	VERB
dti-1375	124	12	using	use	VERB
dti-1375	124	13	‘	'	PUNCT
dti-1375	124	14	image	image	NOUN
dti-1375	124	15	j	j	NOUN
dti-1375	124	16	’	'	PUNCT
dti-1375	124	17	analysis	analysis	NOUN
dti-1375	124	18	to	to	PART
dti-1375	124	19	normalize	normalize	VERB
dti-1375	124	20	loading	loading	NOUN
dti-1375	124	21	controls	control	NOUN
dti-1375	124	22	and	and	CCONJ
dti-1375	124	23	represented	represent	VERB
dti-1375	124	24	in	in	ADP
dti-1375	124	25	bar	bar	NOUN
dti-1375	124	26	diagram	diagram	NOUN
dti-1375	124	27	.	.	PUNCT
dti-1375	125	1	therefore	therefore	ADV
dti-1375	125	2	the	the	DET
dti-1375	125	3	bar	bar	NOUN
dti-1375	125	4	diagrams	diagram	NOUN
dti-1375	125	5	represent	represent	VERB
dti-1375	125	6	fold	fold	ADJ
dti-1375	125	7	gene	gene	NOUN
dti-1375	125	8	expression	expression	NOUN
dti-1375	125	9	compared	compare	VERB
dti-1375	125	10	to	to	ADP
dti-1375	125	11	gapdh	gapdh	NOUN
dti-1375	125	12	(	(	PUNCT
dti-1375	125	13	fig	fig	NOUN
dti-1375	125	14	.	.	PUNCT
dti-1375	125	15	1b1	1b1	NUM
dti-1375	125	16	and	and	CCONJ
dti-1375	125	17	fig	fig	NOUN
dti-1375	125	18	.	.	PUNCT
dti-1375	125	19	1b2	1b2	NUM
dti-1375	125	20	)	)	PUNCT
dti-1375	125	21	.	.	PUNCT
dti-1375	126	1	to	to	PART
dti-1375	126	2	study	study	VERB
dti-1375	126	3	protein	protein	NOUN
dti-1375	126	4	levels	level	NOUN
dti-1375	126	5	of	of	ADP
dti-1375	126	6	tumor	tumor	NOUN
dti-1375	126	7	suppressors	suppressor	NOUN
dti-1375	126	8	,	,	PUNCT
dti-1375	126	9	signal	signal	VERB
dti-1375	126	10	transduction	transduction	NOUN
dti-1375	126	11	and	and	CCONJ
dti-1375	126	12	stress	stress	NOUN
dti-1375	126	13	proteins	protein	NOUN
dti-1375	126	14	,	,	PUNCT
dti-1375	126	15	cell	cell	NOUN
dti-1375	126	16	lysates	lysate	NOUN
dti-1375	126	17	collected	collect	VERB
dti-1375	126	18	at	at	ADP
dti-1375	126	19	day	day	NOUN
dti-1375	126	20	2	2	NUM
dti-1375	126	21	,	,	PUNCT
dti-1375	126	22	4	4	NUM
dti-1375	126	23	and	and	CCONJ
dti-1375	126	24	6	6	NUM
dti-1375	126	25	of	of	ADP
dti-1375	126	26	the	the	DET
dti-1375	126	27	treatments	treatment	NOUN
dti-1375	126	28	were	be	AUX
dti-1375	126	29	examined	examine	VERB
dti-1375	126	30	by	by	ADP
dti-1375	126	31	immunoblot	immunoblot	NOUN
dti-1375	126	32	analysis	analysis	NOUN
dti-1375	126	33	.	.	PUNCT
dti-1375	127	1	prolonged	prolong	VERB
dti-1375	127	2	treatment	treatment	NOUN
dti-1375	127	3	of	of	ADP
dti-1375	127	4	cells	cell	NOUN
dti-1375	127	5	with	with	ADP
dti-1375	127	6	individual	individual	ADJ
dti-1375	127	7	drugs	drug	NOUN
dti-1375	127	8	displayed	display	VERB
dti-1375	127	9	gradual	gradual	ADJ
dti-1375	127	10	but	but	CCONJ
dti-1375	127	11	radical	radical	ADJ
dti-1375	127	12	decrease	decrease	NOUN
dti-1375	127	13	in	in	ADP
dti-1375	127	14	cyclin	cyclin	PROPN
dti-1375	127	15	dependent	dependent	ADJ
dti-1375	127	16	kinases	kinase	NOUN
dti-1375	127	17	,	,	PUNCT
dti-1375	127	18	cdk1	cdk1	PROPN
dti-1375	127	19	,	,	PUNCT
dti-1375	127	20	cdk2	cdk2	PROPN
dti-1375	127	21	and	and	CCONJ
dti-1375	127	22	cdk6	cdk6	PROPN
dti-1375	127	23	,	,	PUNCT
dti-1375	127	24	which	which	PRON
dti-1375	127	25	has	have	VERB
dti-1375	127	26	implications	implication	NOUN
dti-1375	127	27	both	both	PRON
dti-1375	127	28	in	in	ADP
dti-1375	127	29	g1	g1	PROPN
dti-1375	127	30	/	/	SYM
dti-1375	127	31	s	s	NOUN
dti-1375	127	32	and	and	CCONJ
dti-1375	127	33	g2	g2	PROPN
dti-1375	127	34	/	/	SYM
dti-1375	127	35	m	m	PROPN
dti-1375	127	36	cell	cell	NOUN
dti-1375	127	37	cycle	cycle	NOUN
dti-1375	127	38	transitions	transition	NOUN
dti-1375	127	39	.	.	PUNCT
dti-1375	128	1	prolonged	prolonged	ADJ
dti-1375	128	2	combination	combination	NOUN
dti-1375	128	3	treatment	treatment	NOUN
dti-1375	128	4	displayed	display	VERB
dti-1375	128	5	a	a	DET
dti-1375	128	6	decrease	decrease	NOUN
dti-1375	128	7	in	in	ADP
dti-1375	128	8	cdk6	cdk6	NOUN
dti-1375	128	9	alone	alone	ADV
dti-1375	128	10	that	that	PRON
dti-1375	128	11	is	be	AUX
dti-1375	128	12	involved	involve	VERB
dti-1375	128	13	in	in	ADP
dti-1375	128	14	the	the	DET
dti-1375	128	15	g0	g0	NOUN
dti-1375	128	16	to	to	PART
dti-1375	128	17	g1	g1	VERB
dti-1375	128	18	cell	cell	NOUN
dti-1375	128	19	cycle	cycle	NOUN
dti-1375	128	20	transition	transition	NOUN
dti-1375	128	21	.	.	PUNCT
dti-1375	129	1	doxorubicin	doxorubicin	PROPN
dti-1375	129	2	and	and	CCONJ
dti-1375	129	3	17aag	17aag	NOUN
dti-1375	129	4	treatments	treatment	NOUN
dti-1375	129	5	showed	show	VERB
dti-1375	129	6	decrease	decrease	NOUN
dti-1375	129	7	in	in	ADP
dti-1375	129	8	hsp27	hsp27	PROPN
dti-1375	129	9	,	,	PUNCT
dti-1375	129	10	hsp70	hsp70	NOUN
dti-1375	129	11	and	and	CCONJ
dti-1375	129	12	hsp90	hsp90	ADJ
dti-1375	129	13	levels	level	NOUN
dti-1375	129	14	;	;	PUNCT
dti-1375	129	15	interestingly	interestingly	ADV
dti-1375	129	16	,	,	PUNCT
dti-1375	129	17	only	only	ADV
dti-1375	129	18	hsp90	hsp90	ADJ
dti-1375	129	19	levels	level	NOUN
dti-1375	129	20	were	be	AUX
dti-1375	129	21	unaffected	unaffected	ADJ
dti-1375	129	22	by	by	ADP
dti-1375	129	23	the	the	DET
dti-1375	129	24	combination	combination	NOUN
dti-1375	129	25	treatment	treatment	NOUN
dti-1375	129	26	.	.	PUNCT
dti-1375	130	1	consistent	consistent	ADJ
dti-1375	130	2	with	with	ADP
dti-1375	130	3	hsp90	hsp90	ADJ
dti-1375	130	4	levels	level	NOUN
dti-1375	130	5	,	,	PUNCT
dti-1375	130	6	akt	akt	PROPN
dti-1375	130	7	and	and	CCONJ
dti-1375	130	8	erk1/2	erk1/2	PROPN
dti-1375	130	9	basal	basal	NOUN
dti-1375	130	10	levels	level	NOUN
dti-1375	130	11	were	be	AUX
dti-1375	130	12	not	not	PART
dti-1375	130	13	affected	affect	VERB
dti-1375	130	14	by	by	ADP
dti-1375	130	15	the	the	DET
dti-1375	130	16	combination	combination	NOUN
dti-1375	130	17	treatment	treatment	NOUN
dti-1375	130	18	compared	compare	VERB
dti-1375	130	19	to	to	ADP
dti-1375	130	20	individual	individual	ADJ
dti-1375	130	21	treatments	treatment	NOUN
dti-1375	130	22	.	.	PUNCT
dti-1375	131	1	however	however	ADV
dti-1375	131	2	,	,	PUNCT
dti-1375	131	3	the	the	DET
dti-1375	131	4	phosphorylation	phosphorylation	NOUN
dti-1375	131	5	status	status	NOUN
dti-1375	131	6	of	of	ADP
dti-1375	131	7	akt	akt	PROPN
dti-1375	131	8	and	and	CCONJ
dti-1375	131	9	erk1/2	erk1/2	PROPN
dti-1375	131	10	was	be	AUX
dti-1375	131	11	found	find	VERB
dti-1375	131	12	to	to	PART
dti-1375	131	13	be	be	AUX
dti-1375	131	14	decreased	decrease	VERB
dti-1375	131	15	(	(	PUNCT
dti-1375	131	16	fig	fig	NOUN
dti-1375	131	17	.	.	PUNCT
dti-1375	132	1	1c	1c	NOUN
dti-1375	132	2	)	)	PUNCT
dti-1375	132	3	.	.	PUNCT
dti-1375	133	1	17aag	17aag	ADJ
dti-1375	133	2	pre	pre	ADJ
dti-1375	133	3	-	-	NOUN
dti-1375	133	4	treatment	treatment	NOUN
dti-1375	133	5	but	but	CCONJ
dti-1375	133	6	not	not	PART
dti-1375	133	7	the	the	DET
dti-1375	133	8	combination	combination	NOUN
dti-1375	133	9	treatment	treatment	NOUN
dti-1375	133	10	accelerates	accelerate	VERB
dti-1375	133	11	senescence	senescence	NOUN
dti-1375	133	12	response	response	NOUN
dti-1375	133	13	we	we	PRON
dti-1375	133	14	excluded	exclude	VERB
dti-1375	133	15	the	the	DET
dti-1375	133	16	combination	combination	NOUN
dti-1375	133	17	treatments	treatment	NOUN
dti-1375	133	18	in	in	ADP
dti-1375	133	19	our	our	PRON
dti-1375	133	20	subsequent	subsequent	ADJ
dti-1375	133	21	study	study	NOUN
dti-1375	133	22	,	,	PUNCT
dti-1375	133	23	because	because	SCONJ
dti-1375	133	24	prolonged	prolonged	ADJ
dti-1375	133	25	treatments	treatment	NOUN
dti-1375	133	26	interfered	interfere	VERB
dti-1375	133	27	with	with	ADP
dti-1375	133	28	senescence	senescence	NOUN
dti-1375	133	29	activation	activation	NOUN
dti-1375	133	30	by	by	ADP
dti-1375	133	31	inducing	induce	VERB
dti-1375	133	32	early	early	ADJ
dti-1375	133	33	cytotoxicity	cytotoxicity	NOUN
dti-1375	133	34	(	(	PUNCT
dti-1375	133	35	suppl	suppl	PROPN
dti-1375	133	36	.	.	PUNCT
dti-1375	133	37	fig	fig	PROPN
dti-1375	133	38	.	.	PUNCT
dti-1375	134	1	1b	1b	NUM
dti-1375	134	2	)	)	PUNCT
dti-1375	134	3	.	.	PUNCT
dti-1375	135	1	in	in	ADP
dti-1375	135	2	the	the	DET
dti-1375	135	3	following	follow	VERB
dti-1375	135	4	experiments	experiment	NOUN
dti-1375	135	5	,	,	PUNCT
dti-1375	135	6	we	we	PRON
dti-1375	135	7	studied	study	VERB
dti-1375	135	8	pre	pre	ADJ
dti-1375	135	9	-	-	ADJ
dti-1375	135	10	sensitizing	sensitizing	ADJ
dti-1375	135	11	effects	effect	NOUN
dti-1375	135	12	of	of	ADP
dti-1375	135	13	drugs	drug	NOUN
dti-1375	135	14	on	on	ADP
dti-1375	135	15	senescence	senescence	NOUN
dti-1375	135	16	acceleration	acceleration	NOUN
dti-1375	135	17	.	.	PUNCT
dti-1375	136	1	in	in	ADP
dti-1375	136	2	brief	brief	ADJ
dti-1375	136	3	,	,	PUNCT
dti-1375	136	4	cells	cell	NOUN
dti-1375	136	5	were	be	AUX
dti-1375	136	6	treated	treat	VERB
dti-1375	136	7	with	with	ADP
dti-1375	136	8	doxorubicin	doxorubicin	PROPN
dti-1375	136	9	or	or	CCONJ
dti-1375	136	10	17aag	17aag	NOUN
dti-1375	136	11	for	for	ADP
dti-1375	136	12	24	24	NUM
dti-1375	136	13	h	h	NOUN
dti-1375	136	14	and	and	CCONJ
dti-1375	136	15	the	the	DET
dti-1375	136	16	drug	drug	NOUN
dti-1375	136	17	containing	contain	VERB
dti-1375	136	18	medium	medium	NOUN
dti-1375	136	19	was	be	AUX
dti-1375	136	20	replaced	replace	VERB
dti-1375	136	21	with	with	ADP
dti-1375	136	22	fresh	fresh	ADJ
dti-1375	136	23	medium	medium	ADJ
dti-1375	136	24	containing	contain	VERB
dti-1375	136	25	17aag	17aag	NOUN
dti-1375	136	26	or	or	CCONJ
dti-1375	136	27	doxorubicin	doxorubicin	VERB
dti-1375	136	28	for	for	ADP
dti-1375	136	29	5	5	NUM
dti-1375	136	30	-	-	PUNCT
dti-1375	136	31	days	day	NOUN
dti-1375	136	32	were	be	AUX
dti-1375	136	33	examined	examine	VERB
dti-1375	136	34	for	for	ADP
dti-1375	136	35	sa	sa	PROPN
dti-1375	136	36	-	-	PUNCT
dti-1375	136	37	β	β	NOUN
dti-1375	136	38	-	-	ADJ
dti-1375	136	39	gal	gal	ADJ
dti-1375	136	40	staining	staining	NOUN
dti-1375	136	41	.	.	PUNCT
dti-1375	137	1	doxorubicin	doxorubicin	PROPN
dti-1375	137	2	pretreatment	pretreatment	NOUN
dti-1375	137	3	followed	follow	VERB
dti-1375	137	4	by	by	ADP
dti-1375	137	5	17aag	17aag	ADJ
dti-1375	137	6	treatment	treatment	NOUN
dti-1375	137	7	showed	show	VERB
dti-1375	137	8	fewer	few	ADJ
dti-1375	137	9	sa	sa	NOUN
dti-1375	137	10	-	-	PUNCT
dti-1375	137	11	β	β	NOUN
dti-1375	137	12	-	-	ADJ
dti-1375	137	13	gal	gal	ADJ
dti-1375	137	14	positive	positive	ADJ
dti-1375	137	15	cells	cell	NOUN
dti-1375	137	16	(	(	PUNCT
dti-1375	137	17	15	15	NUM
dti-1375	137	18	%	%	NOUN
dti-1375	137	19	±	±	NUM
dti-1375	137	20	2	2	NUM
dti-1375	137	21	%	%	NOUN
dti-1375	137	22	)	)	PUNCT
dti-1375	137	23	by	by	ADP
dti-1375	137	24	day-6	day-6	ADV
dti-1375	137	25	and	and	CCONJ
dti-1375	137	26	17aag	17aag	ADJ
dti-1375	137	27	pre	pre	ADJ
dti-1375	137	28	-	-	NOUN
dti-1375	137	29	treatment	treatment	NOUN
dti-1375	137	30	followed	follow	VERB
dti-1375	137	31	by	by	ADP
dti-1375	137	32	doxorubicin	doxorubicin	PROPN
dti-1375	137	33	treatment	treatment	NOUN
dti-1375	137	34	resulted	result	VERB
dti-1375	137	35	in	in	ADP
dti-1375	137	36	early	early	ADJ
dti-1375	137	37	(	(	PUNCT
dti-1375	137	38	day-2	day-2	NOUN
dti-1375	137	39	,	,	PUNCT
dti-1375	137	40	data	datum	NOUN
dti-1375	137	41	not	not	PART
dti-1375	137	42	shown	show	VERB
dti-1375	137	43	)	)	PUNCT
dti-1375	137	44	sa	sa	AUX
dti-1375	137	45	-	-	PUNCT
dti-1375	137	46	β	β	NOUN
dti-1375	137	47	-	-	ADJ
dti-1375	137	48	gal	gal	ADJ
dti-1375	137	49	positive	positive	ADJ
dti-1375	137	50	cells	cell	NOUN
dti-1375	137	51	(	(	PUNCT
dti-1375	137	52	65	65	NUM
dti-1375	137	53	%	%	NOUN
dti-1375	137	54	±	±	NUM
dti-1375	137	55	11	11	NUM
dti-1375	137	56	%	%	NOUN
dti-1375	137	57	)	)	PUNCT
dti-1375	137	58	by	by	ADP
dti-1375	137	59	day-6	day-6	ADV
dti-1375	137	60	(	(	PUNCT
dti-1375	137	61	fig	fig	NOUN
dti-1375	137	62	.	.	PUNCT
dti-1375	138	1	2a	2a	NUM
dti-1375	138	2	and	and	CCONJ
dti-1375	138	3	2	2	NUM
dti-1375	138	4	a1	a1	NOUN
dti-1375	138	5	,	,	PUNCT
dti-1375	138	6	p	p	NOUN
dti-1375	138	7	,	,	PUNCT
dti-1375	138	8	0.001	0.001	NUM
dti-1375	138	9	)	)	PUNCT
dti-1375	138	10	.	.	PUNCT
dti-1375	139	1	these	these	DET
dti-1375	139	2	results	result	NOUN
dti-1375	139	3	suggested	suggest	VERB
dti-1375	139	4	that	that	SCONJ
dti-1375	139	5	17aag	17aag	ADJ
dti-1375	139	6	pre	pre	ADJ
dti-1375	139	7	-	-	NOUN
dti-1375	139	8	treatment	treatment	NOUN
dti-1375	139	9	accelerates	accelerate	VERB
dti-1375	139	10	doxorubicin	doxorubicin	PROPN
dti-1375	139	11	induced	induce	VERB
dti-1375	139	12	cellular	cellular	ADJ
dti-1375	139	13	senescence	senescence	NOUN
dti-1375	139	14	,	,	PUNCT
dti-1375	139	15	whereas	whereas	ADV
dti-1375	139	16	,	,	PUNCT
dti-1375	139	17	doxororubicin	doxororubicin	VERB
dti-1375	139	18	pre	pre	NOUN
dti-1375	139	19	-	-	NOUN
dti-1375	139	20	treatment	treatment	NOUN
dti-1375	139	21	showed	show	VERB
dti-1375	139	22	a	a	DET
dti-1375	139	23	response	response	NOUN
dti-1375	139	24	similar	similar	ADJ
dti-1375	139	25	to	to	ADP
dti-1375	139	26	doxorubicin	doxorubicin	PROPN
dti-1375	139	27	treatment	treatment	NOUN
dti-1375	139	28	(	(	PUNCT
dti-1375	139	29	compare	compare	VERB
dti-1375	139	30	fig	fig	NOUN
dti-1375	139	31	.	.	PUNCT
dti-1375	140	1	1a	1a	PROPN
dti-1375	140	2	with	with	ADP
dti-1375	140	3	fig	fig	NOUN
dti-1375	140	4	.	.	PUNCT
dti-1375	141	1	2a	2a	NUM
dti-1375	141	2	)	)	PUNCT
dti-1375	141	3	.	.	PUNCT
dti-1375	142	1	in	in	ADP
dti-1375	142	2	both	both	CCONJ
dti-1375	142	3	the	the	DET
dti-1375	142	4	pretreatments	pretreatment	NOUN
dti-1375	142	5	,	,	PUNCT
dti-1375	142	6	sa	sa	NOUN
dti-1375	142	7	-	-	PUNCT
dti-1375	142	8	β	β	NOUN
dti-1375	142	9	-	-	ADJ
dti-1375	142	10	gal	gal	ADJ
dti-1375	142	11	activity	activity	NOUN
dti-1375	142	12	was	be	AUX
dti-1375	142	13	correlating	correlate	VERB
dti-1375	142	14	with	with	ADP
dti-1375	142	15	typical	typical	ADJ
dti-1375	142	16	senescence	senescence	NOUN
dti-1375	142	17	morphology	morphology	NOUN
dti-1375	142	18	(	(	PUNCT
dti-1375	142	19	suppl	suppl	PROPN
dti-1375	142	20	.	.	PUNCT
dti-1375	142	21	fig	fig	PROPN
dti-1375	142	22	.	.	PUNCT
dti-1375	143	1	2a	2a	NUM
dti-1375	143	2	)	)	PUNCT
dti-1375	143	3	.	.	PUNCT
dti-1375	144	1	however	however	ADV
dti-1375	144	2	,	,	PUNCT
dti-1375	144	3	doxorubicin	doxorubicin	PROPN
dti-1375	144	4	pretreatment	pretreatment	NOUN
dti-1375	144	5	resulted	result	VERB
dti-1375	144	6	in	in	ADP
dti-1375	144	7	enhanced	enhanced	ADJ
dti-1375	144	8	cytotoxicity	cytotoxicity	NOUN
dti-1375	144	9	in	in	ADP
dti-1375	144	10	comparison	comparison	NOUN
dti-1375	144	11	with	with	ADP
dti-1375	144	12	17aag	17aag	ADJ
dti-1375	144	13	pre	pre	NOUN
dti-1375	144	14	-	-	NOUN
dti-1375	144	15	treatment	treatment	ADJ
dti-1375	144	16	(	(	PUNCT
dti-1375	144	17	suppl	suppl	PROPN
dti-1375	144	18	.	.	PUNCT
dti-1375	144	19	fig	fig	PROPN
dti-1375	144	20	.	.	PUNCT
dti-1375	145	1	2b	2b	NUM
dti-1375	145	2	)	)	PUNCT
dti-1375	145	3	.	.	PUNCT
dti-1375	146	1	these	these	DET
dti-1375	146	2	findings	finding	NOUN
dti-1375	146	3	establish	establish	VERB
dti-1375	146	4	that	that	SCONJ
dti-1375	146	5	prolonged	prolonged	ADJ
dti-1375	146	6	treatment	treatment	NOUN
dti-1375	146	7	of	of	ADP
dti-1375	146	8	cells	cell	NOUN
dti-1375	146	9	with	with	ADP
dti-1375	146	10	17aag	17aag	NOUN
dti-1375	146	11	affects	affect	VERB
dti-1375	146	12	senescence	senescence	NOUN
dti-1375	146	13	activation	activation	NOUN
dti-1375	146	14	.	.	PUNCT
dti-1375	147	1	further	far	ADV
dti-1375	147	2	,	,	PUNCT
dti-1375	147	3	a	a	DET
dti-1375	147	4	decrease	decrease	NOUN
dti-1375	147	5	in	in	ADP
dti-1375	147	6	cytotoxicity	cytotoxicity	NOUN
dti-1375	147	7	(	(	PUNCT
dti-1375	147	8	fig	fig	NOUN
dti-1375	147	9	.	.	PUNCT
dti-1375	148	1	2b	2b	NOUN
dti-1375	148	2	,	,	PUNCT
dti-1375	148	3	p	p	NOUN
dti-1375	148	4	,	,	PUNCT
dti-1375	148	5	0.001	0.001	NUM
dti-1375	148	6	)	)	PUNCT
dti-1375	148	7	in	in	ADP
dti-1375	148	8	17aag	17aag	ADJ
dti-1375	148	9	pre	pre	NOUN
dti-1375	148	10	-	-	NOUN
dti-1375	148	11	treatment	treatment	NOUN
dti-1375	148	12	was	be	AUX
dti-1375	148	13	correlated	correlate	VERB
dti-1375	148	14	with	with	ADP
dti-1375	148	15	enhanced	enhanced	ADJ
dti-1375	148	16	senescence	senescence	NOUN
dti-1375	148	17	(	(	PUNCT
dti-1375	148	18	fig	fig	NOUN
dti-1375	148	19	.	.	PUNCT
dti-1375	149	1	2a	2a	NUM
dti-1375	149	2	)	)	PUNCT
dti-1375	149	3	,	,	PUNCT
dti-1375	149	4	which	which	PRON
dti-1375	149	5	is	be	AUX
dti-1375	149	6	in	in	ADP
dti-1375	149	7	agreement	agreement	NOUN
dti-1375	149	8	with	with	ADP
dti-1375	149	9	the	the	DET
dti-1375	149	10	accumulation	accumulation	NOUN
dti-1375	149	11	of	of	ADP
dti-1375	149	12	cells	cell	NOUN
dti-1375	149	13	in	in	ADP
dti-1375	149	14	g1	g1	PROPN
dti-1375	149	15	/	/	SYM
dti-1375	149	16	s	s	AUX
dti-1375	149	17	being	be	AUX
dti-1375	149	18	a	a	DET
dti-1375	149	19	pre	pre	NOUN
dti-1375	149	20	-	-	NOUN
dti-1375	149	21	requisite	requisite	ADJ
dti-1375	149	22	for	for	ADP
dti-1375	149	23	senescence	senescence	NOUN
dti-1375	149	24	activation	activation	NOUN
dti-1375	149	25	(	(	PUNCT
dti-1375	149	26	14	14	NUM
dti-1375	149	27	;	;	PUNCT
dti-1375	149	28	fig	fig	NOUN
dti-1375	149	29	.	.	PUNCT
dti-1375	150	1	2c	2c	NUM
dti-1375	150	2	,	,	PUNCT
dti-1375	150	3	p	p	NOUN
dti-1375	150	4	,	,	PUNCT
dti-1375	150	5	0.001	0.001	NUM
dti-1375	150	6	)	)	PUNCT
dti-1375	150	7	.	.	PUNCT
dti-1375	151	1	17aag	17aag	ADJ
dti-1375	151	2	pre	pre	ADJ
dti-1375	151	3	-	-	NOUN
dti-1375	151	4	treatment	treatment	NOUN
dti-1375	151	5	retains	retain	VERB
dti-1375	151	6	survival	survival	NOUN
dti-1375	151	7	potential	potential	NOUN
dti-1375	151	8	to	to	PART
dti-1375	151	9	investigate	investigate	VERB
dti-1375	151	10	the	the	DET
dti-1375	151	11	difference	difference	NOUN
dti-1375	151	12	in	in	ADP
dti-1375	151	13	molecular	molecular	ADJ
dti-1375	151	14	mechanism	mechanism	NOUN
dti-1375	151	15	of	of	ADP
dti-1375	151	16	senescence	senescence	NOUN
dti-1375	151	17	activation	activation	NOUN
dti-1375	151	18	in	in	ADP
dti-1375	151	19	the	the	DET
dti-1375	151	20	pre	pre	NOUN
dti-1375	151	21	-	-	NOUN
dti-1375	151	22	treatments	treatment	NOUN
dti-1375	151	23	,	,	PUNCT
dti-1375	151	24	the	the	DET
dti-1375	151	25	rt	rt	ADJ
dti-1375	151	26	-	-	PUNCT
dti-1375	151	27	pcr	pcr	NOUN
dti-1375	151	28	analysis	analysis	NOUN
dti-1375	151	29	of	of	ADP
dti-1375	151	30	cell	cell	NOUN
dti-1375	151	31	cycle	cycle	NOUN
dti-1375	151	32	regulators	regulator	NOUN
dti-1375	151	33	was	be	AUX
dti-1375	151	34	performed	perform	VERB
dti-1375	151	35	.	.	PUNCT
dti-1375	152	1	a	a	DET
dti-1375	152	2	gradual	gradual	ADJ
dti-1375	152	3	decrease	decrease	NOUN
dti-1375	152	4	in	in	ADP
dti-1375	152	5	p21cip	p21cip	PROPN
dti-1375	152	6	/	/	SYM
dti-1375	152	7	waf-1	waf-1	X
dti-1375	152	8	in	in	ADP
dti-1375	152	9	doxorubicin	doxorubicin	PROPN
dti-1375	152	10	pre	pre	NOUN
dti-1375	152	11	-	-	NOUN
dti-1375	152	12	treatment	treatment	NOUN
dti-1375	152	13	and	and	CCONJ
dti-1375	152	14	a	a	DET
dti-1375	152	15	steady	steady	ADJ
dti-1375	152	16	increase	increase	NOUN
dti-1375	152	17	in	in	ADP
dti-1375	152	18	17aag	17aag	ADJ
dti-1375	152	19	pre	pre	ADJ
dti-1375	152	20	-	-	NOUN
dti-1375	152	21	treatment	treatment	NOUN
dti-1375	152	22	correlated	correlate	VERB
dti-1375	152	23	with	with	ADP
dti-1375	152	24	increased	increase	VERB
dti-1375	152	25	expression	expression	NOUN
dti-1375	152	26	of	of	ADP
dti-1375	152	27	p53	p53	NOUN
dti-1375	152	28	suggesting	suggest	VERB
dti-1375	152	29	involvement	involvement	NOUN
dti-1375	152	30	of	of	ADP
dti-1375	152	31	p53	p53	NOUN
dti-1375	152	32	and	and	CCONJ
dti-1375	152	33	p21cip/	p21cip/	NOUN
dti-1375	152	34	waf-1	waf-1	ADP
dti-1375	152	35	in	in	ADP
dti-1375	152	36	senescence	senescence	NOUN
dti-1375	152	37	activation	activation	NOUN
dti-1375	152	38	.	.	PUNCT
dti-1375	153	1	the	the	DET
dti-1375	153	2	increased	increase	VERB
dti-1375	153	3	p21cip/	p21cip/	NOUN
dti-1375	153	4	waf-1	waf-1	ADP
dti-1375	153	5	but	but	CCONJ
dti-1375	153	6	not	not	PART
dti-1375	153	7	p16ink4a	p16ink4a	NOUN
dti-1375	153	8	expression	expression	NOUN
dti-1375	153	9	correlated	correlate	VERB
dti-1375	153	10	with	with	ADP
dti-1375	153	11	enhanced	enhanced	ADJ
dti-1375	153	12	sa	sa	VERB
dti-1375	153	13	-	-	PUNCT
dti-1375	153	14	β	β	NOUN
dti-1375	153	15	-	-	ADJ
dti-1375	153	16	gal	gal	ADJ
dti-1375	153	17	staining	stain	VERB
dti-1375	153	18	further	far	ADV
dti-1375	153	19	suggested	suggest	VERB
dti-1375	153	20	activation	activation	NOUN
dti-1375	153	21	of	of	ADP
dti-1375	153	22	stress	stress	NOUN
dti-1375	153	23	induced	induce	VERB
dti-1375	153	24	cellular	cellular	ADJ
dti-1375	153	25	senescence	senescence	NOUN
dti-1375	153	26	.	.	PUNCT
dti-1375	154	1	increases	increase	NOUN
dti-1375	154	2	in	in	ADP
dti-1375	154	3	hsp27	hsp27	PROPN
dti-1375	154	4	,	,	PUNCT
dti-1375	154	5	hsp70	hsp70	NOUN
dti-1375	154	6	and	and	CCONJ
dti-1375	154	7	hsp90	hsp90	ADJ
dti-1375	154	8	levels	level	NOUN
dti-1375	154	9	in	in	ADP
dti-1375	154	10	both	both	CCONJ
dti-1375	154	11	the	the	DET
dti-1375	154	12	pretreatments	pretreatment	NOUN
dti-1375	154	13	suggest	suggest	VERB
dti-1375	154	14	induced	induce	VERB
dti-1375	154	15	synthesis	synthesis	NOUN
dti-1375	154	16	or	or	CCONJ
dti-1375	154	17	enhanced	enhance	VERB
dti-1375	154	18	stabilization	stabilization	NOUN
dti-1375	154	19	of	of	ADP
dti-1375	154	20	their	their	PRON
dti-1375	154	21	hsp	hsp	NOUN
dti-1375	154	22	mrna	mrna	PROPN
dti-1375	154	23	(	(	PUNCT
dti-1375	154	24	fig	fig	NOUN
dti-1375	154	25	.	.	PUNCT
dti-1375	155	1	2d	2d	NOUN
dti-1375	155	2	)	)	PUNCT
dti-1375	155	3	.	.	PUNCT
dti-1375	156	1	specific	specific	ADJ
dti-1375	156	2	gene	gene	NOUN
dti-1375	156	3	expression	expression	NOUN
dti-1375	156	4	was	be	AUX
dti-1375	156	5	calculated	calculate	VERB
dti-1375	156	6	using	use	VERB
dti-1375	156	7	image	image	NOUN
dti-1375	156	8	j	j	PROPN
dti-1375	156	9	analysis	analysis	NOUN
dti-1375	156	10	in	in	ADP
dti-1375	156	11	comparison	comparison	NOUN
dti-1375	156	12	with	with	ADP
dti-1375	156	13	gapdh	gapdh	NOUN
dti-1375	156	14	to	to	PART
dti-1375	156	15	normalize	normalize	VERB
dti-1375	156	16	loading	loading	NOUN
dti-1375	156	17	controls	control	NOUN
dti-1375	156	18	and	and	CCONJ
dti-1375	156	19	represented	represent	VERB
dti-1375	156	20	in	in	ADP
dti-1375	156	21	bar	bar	NOUN
dti-1375	156	22	diagram	diagram	NOUN
dti-1375	156	23	(	(	PUNCT
dti-1375	156	24	fig	fig	NOUN
dti-1375	156	25	.	.	PUNCT
dti-1375	157	1	2d1	2d1	NUM
dti-1375	157	2	)	)	PUNCT
dti-1375	157	3	.	.	PUNCT
dti-1375	158	1	next	next	ADV
dti-1375	158	2	,	,	PUNCT
dti-1375	158	3	we	we	PRON
dti-1375	158	4	examined	examine	VERB
dti-1375	158	5	protein	protein	NOUN
dti-1375	158	6	profiles	profile	NOUN
dti-1375	158	7	of	of	ADP
dti-1375	158	8	regulatory	regulatory	ADJ
dti-1375	158	9	molecules	molecule	NOUN
dti-1375	158	10	by	by	ADP
dti-1375	158	11	immunoblot	immunoblot	NOUN
dti-1375	158	12	analysis	analysis	NOUN
dti-1375	158	13	using	use	VERB
dti-1375	158	14	lysates	lysate	NOUN
dti-1375	158	15	of	of	ADP
dti-1375	158	16	drug	drug	NOUN
dti-1375	158	17	treated	treat	VERB
dti-1375	158	18	cells	cell	NOUN
dti-1375	158	19	at	at	ADP
dti-1375	158	20	days	day	NOUN
dti-1375	158	21	2	2	NUM
dti-1375	158	22	,	,	PUNCT
dti-1375	158	23	4	4	NUM
dti-1375	158	24	and	and	CCONJ
dti-1375	158	25	6	6	NUM
dti-1375	158	26	.	.	PUNCT
dti-1375	159	1	though	though	SCONJ
dti-1375	159	2	there	there	PRON
dti-1375	159	3	http://www.la-press.com	http://www.la-press.com	X
dti-1375	159	4	hsp90	hsp90	ADJ
dti-1375	159	5	inhibition	inhibition	NOUN
dti-1375	159	6	accelerates	accelerate	VERB
dti-1375	159	7	senescence	senescence	NOUN
dti-1375	159	8	drug	drug	NOUN
dti-1375	159	9	target	target	NOUN
dti-1375	159	10	insights	insight	NOUN
dti-1375	159	11	2012:6	2012:6	NUM
dti-1375	159	12	25	25	NUM
dti-1375	159	13	was	be	AUX
dti-1375	159	14	some	some	DET
dti-1375	159	15	fluctuation	fluctuation	NOUN
dti-1375	159	16	in	in	ADP
dti-1375	159	17	cdk1	cdk1	PROPN
dti-1375	159	18	levels	level	NOUN
dti-1375	159	19	,	,	PUNCT
dti-1375	159	20	no	no	DET
dti-1375	159	21	significant	significant	ADJ
dti-1375	159	22	change	change	NOUN
dti-1375	159	23	was	be	AUX
dti-1375	159	24	observed	observe	VERB
dti-1375	159	25	both	both	CCONJ
dti-1375	159	26	in	in	ADP
dti-1375	159	27	doxorubicin	doxorubicin	PROPN
dti-1375	159	28	pretreatment	pretreatment	NOUN
dti-1375	159	29	or	or	CCONJ
dti-1375	159	30	17aag	17aag	ADJ
dti-1375	159	31	pre	pre	NOUN
dti-1375	159	32	-	-	NOUN
dti-1375	159	33	treatments	treatment	NOUN
dti-1375	159	34	suggesting	suggest	VERB
dti-1375	159	35	no	no	DET
dti-1375	159	36	effect	effect	NOUN
dti-1375	159	37	on	on	ADP
dti-1375	159	38	mitosis	mitosis	NOUN
dti-1375	159	39	.	.	PUNCT
dti-1375	159	40	increased	increase	VERB
dti-1375	159	41	cdk2	cdk2	PROPN
dti-1375	159	42	in	in	ADP
dti-1375	159	43	doxorubicin	doxorubicin	PROPN
dti-1375	159	44	pretreatment	pretreatment	NOUN
dti-1375	159	45	suggested	suggest	VERB
dti-1375	159	46	g1	g1	PROPN
dti-1375	159	47	clearing	clearing	NOUN
dti-1375	159	48	of	of	ADP
dti-1375	159	49	cells	cell	NOUN
dti-1375	159	50	but	but	CCONJ
dti-1375	159	51	variability	variability	NOUN
dti-1375	159	52	in	in	ADP
dti-1375	159	53	17aag	17aag	ADJ
dti-1375	159	54	pre	pre	ADJ
dti-1375	159	55	-	-	ADJ
dti-1375	159	56	treatment	treatment	ADJ
dti-1375	159	57	suggest	suggest	VERB
dti-1375	159	58	crisis	crisis	NOUN
dti-1375	159	59	in	in	ADP
dti-1375	159	60	cellular	cellular	ADJ
dti-1375	159	61	decision	decision	NOUN
dti-1375	159	62	making	making	NOUN
dti-1375	159	63	.	.	PUNCT
dti-1375	160	1	the	the	DET
dti-1375	160	2	decrease	decrease	NOUN
dti-1375	160	3	in	in	ADP
dti-1375	160	4	cdk6	cdk6	NOUN
dti-1375	160	5	levels	level	NOUN
dti-1375	160	6	in	in	ADP
dti-1375	160	7	both	both	CCONJ
dti-1375	160	8	the	the	DET
dti-1375	160	9	pre	pre	NOUN
dti-1375	160	10	-	-	NOUN
dti-1375	160	11	treatments	treatment	NOUN
dti-1375	160	12	suggests	suggest	VERB
dti-1375	160	13	inability	inability	NOUN
dti-1375	160	14	of	of	ADP
dti-1375	160	15	cells	cell	NOUN
dti-1375	160	16	to	to	PART
dti-1375	160	17	re	re	VERB
dti-1375	160	18	-	-	VERB
dti-1375	160	19	enter	enter	VERB
dti-1375	160	20	cell	cell	NOUN
dti-1375	160	21	cycle	cycle	NOUN
dti-1375	160	22	and	and	CCONJ
dti-1375	160	23	can	can	AUX
dti-1375	160	24	be	be	AUX
dti-1375	160	25	argued	argue	VERB
dti-1375	160	26	with	with	ADP
dti-1375	160	27	irreversible	irreversible	ADJ
dti-1375	160	28	effects	effect	NOUN
dti-1375	160	29	of	of	ADP
dti-1375	160	30	cell	cell	NOUN
dti-1375	160	31	cycle	cycle	NOUN
dti-1375	160	32	inhibition	inhibition	NOUN
dti-1375	160	33	.	.	PUNCT
dti-1375	161	1	while	while	SCONJ
dti-1375	161	2	hsp90	hsp90	ADJ
dti-1375	161	3	levels	level	NOUN
dti-1375	161	4	were	be	AUX
dti-1375	161	5	unaffected	unaffected	ADJ
dti-1375	161	6	by	by	ADP
dti-1375	161	7	neither	neither	PRON
dti-1375	161	8	of	of	ADP
dti-1375	161	9	pre	pre	NOUN
dti-1375	161	10	-	-	NOUN
dti-1375	161	11	treatments	treatment	NOUN
dti-1375	161	12	,	,	PUNCT
dti-1375	161	13	hsp27	hsp27	PROPN
dti-1375	161	14	and	and	CCONJ
dti-1375	161	15	hsp70	hsp70	NOUN
dti-1375	161	16	levels	level	NOUN
dti-1375	161	17	showed	show	VERB
dti-1375	161	18	an	an	DET
dti-1375	161	19	initial	initial	ADJ
dti-1375	161	20	increase	increase	NOUN
dti-1375	161	21	control	control	NOUN
dti-1375	161	22	doxo--17aag	doxo--17aag	ADJ
dti-1375	161	23	17aag	17aag	NOUN
dti-1375	161	24	--	--	PUNCT
dti-1375	161	25	doxo	doxo	VERB
dti-1375	161	26	dox-17aag	dox-17aag	PART
dti-1375	161	27	17aag	17aag	NOUN
dti-1375	161	28	--doxo	--doxo	PROPN
dti-1375	161	29	6da	6da	NOUN
dti-1375	161	30	ys	ys	VERB
dti-1375	161	31	a	a	DET
dti-1375	161	32	b	b	NOUN
dti-1375	161	33	c	c	NOUN
dti-1375	162	1	d	d	X
dti-1375	162	2	d1	d1	PROPN
dti-1375	162	3	e	e	X
dti-1375	162	4	day	day	NOUN
dti-1375	162	5	1	1	NUM
dti-1375	162	6	tumor	tumor	NOUN
dti-1375	162	7	senescence	senescence	NOUN
dti-1375	162	8	6	6	NUM
dti-1375	162	9	(	(	PUNCT
dti-1375	162	10	%	%	NOUN
dti-1375	162	11	)	)	PUNCT
dti-1375	162	12	15	15	NUM
dti-1375	162	13	65	65	NUM
dti-1375	162	14	a1	a1	NOUN
dti-1375	162	15	doxo--17aag	doxo--17aag	ADJ
dti-1375	162	16	17aag	17aag	NOUN
dti-1375	162	17	--	--	PUNCT
dti-1375	162	18	doxo	doxo	ADJ
dti-1375	162	19	con	con	X
dti-1375	162	20	2	2	NUM
dti-1375	162	21	4	4	NUM
dti-1375	162	22	6	6	NUM
dti-1375	162	23	2	2	NUM
dti-1375	162	24	4	4	NUM
dti-1375	162	25	6	6	NUM
dti-1375	162	26	doxo--17aag	doxo--17aag	NOUN
dti-1375	162	27	17aag	17aag	NOUN
dti-1375	162	28	--	--	PUNCT
dti-1375	162	29	doxo	doxo	ADJ
dti-1375	162	30	con	con	X
dti-1375	162	31	2	2	NUM
dti-1375	162	32	4	4	NUM
dti-1375	162	33	6	6	NUM
dti-1375	162	34	2	2	NUM
dti-1375	162	35	4	4	NUM
dti-1375	162	36	6	6	NUM
dti-1375	162	37	days	day	NOUN
dti-1375	162	38	cdk1	cdk1	PROPN
dti-1375	162	39	cdk2	cdk2	PROPN
dti-1375	162	40	cdk6	cdk6	PROPN
dti-1375	162	41	hsp27	hsp27	PROPN
dti-1375	162	42	hsp70	hsp70	PROPN
dti-1375	162	43	hsp90	hsp90	VERB
dti-1375	162	44	akt	akt	PROPN
dti-1375	162	45	erk1/2	erk1/2	PROPN
dti-1375	162	46	gapdh	gapdh	NOUN
dti-1375	162	47	p	p	PROPN
dti-1375	162	48	-	-	PUNCT
dti-1375	162	49	akt	akt	PROPN
dti-1375	162	50	(	(	PUNCT
dti-1375	162	51	ser	ser	NOUN
dti-1375	162	52	473	473	NUM
dti-1375	162	53	)	)	PUNCT
dti-1375	162	54	erk1/2	erk1/2	PROPN
dti-1375	163	1	(	(	PUNCT
dti-1375	163	2	thr	thr	PROPN
dti-1375	163	3	202	202	NUM
dti-1375	163	4	)	)	PUNCT
dti-1375	163	5	p53	p53	NOUN
dti-1375	163	6	p21	p21	PROPN
dti-1375	163	7	cyclin	cyclin	PROPN
dti-1375	163	8	d1c	d1c	PROPN
dti-1375	164	1	el	el	PROPN
dti-1375	164	2	l	l	PROPN
dti-1375	164	3	c	c	X
dti-1375	164	4	yc	yc	X
dti-1375	164	5	le	le	X
dti-1375	164	6	r	r	PROPN
dti-1375	164	7	eg	eg	PROPN
dti-1375	164	8	ul	ul	INTJ
dti-1375	164	9	at	at	ADP
dti-1375	164	10	or	or	CCONJ
dti-1375	164	11	s	s	PRON
dti-1375	164	12	h	h	NOUN
dti-1375	164	13	sp	sp	ADP
dti-1375	164	14	s	s	NOUN
dti-1375	164	15	s	s	VERB
dti-1375	164	16	ig	ig	NOUN
dti-1375	164	17	na	na	NOUN
dti-1375	164	18	lin	lin	PROPN
dti-1375	164	19	g	g	PROPN
dti-1375	164	20	m	m	PROPN
dti-1375	164	21	ol	ol	PROPN
dti-1375	164	22	ec	ec	PROPN
dti-1375	164	23	ul	ul	PROPN
dti-1375	164	24	es	es	PROPN
dti-1375	164	25	control	control	PROPN
dti-1375	165	1	doxorubicin	doxorubicin	PROPN
dti-1375	165	2	17aag	17aag	PROPN
dti-1375	165	3	doxorubicin	doxorubicin	PROPN
dti-1375	166	1	+	+	CCONJ
dti-1375	166	2	17aag	17aag	ADJ
dti-1375	166	3	doxorubicin--17aag	doxorubicin--17aag	NOUN
dti-1375	166	4	17aag	17aag	NOUN
dti-1375	166	5	--	--	PUNCT
dti-1375	166	6	doxorubicin	doxorubicin	PROPN
dti-1375	166	7	doxorubicin	doxorubicin	PROPN
dti-1375	166	8	17aag	17aag	PROPN
dti-1375	166	9	doxorubicin	doxorubicin	PROPN
dti-1375	167	1	+	+	CCONJ
dti-1375	167	2	17aag	17aag	ADJ
dti-1375	167	3	doxorubicin--17aag	doxorubicin--17aag	NOUN
dti-1375	167	4	17aag	17aag	NOUN
dti-1375	167	5	--	--	PUNCT
dti-1375	167	6	doxorubicin	doxorubicin	PROPN
dti-1375	167	7	p	p	PROPN
dti-1375	167	8	er	er	INTJ
dti-1375	167	9	ce	ce	PROPN
dti-1375	167	10	n	n	ADP
dti-1375	167	11	t	t	NOUN
dti-1375	167	12	g	g	PROPN
dti-1375	167	13	1	1	NUM
dti-1375	167	14	p	p	NOUN
dti-1375	167	15	o	o	X
dti-1375	167	16	p	p	X
dti-1375	167	17	u	u	X
dti-1375	167	18	la	la	X
dti-1375	167	19	ti	ti	X
dti-1375	167	20	o	o	NOUN
dti-1375	167	21	n	n	CCONJ
dti-1375	167	22	0	0	NUM
dti-1375	167	23	20	20	NUM
dti-1375	167	24	40	40	NUM
dti-1375	167	25	60	60	NUM
dti-1375	167	26	80	80	NUM
dti-1375	167	27	100	100	NUM
dti-1375	167	28	p	p	NOUN
dti-1375	167	29	er	er	INTJ
dti-1375	167	30	ce	ce	PROPN
dti-1375	167	31	n	n	PROPN
dti-1375	167	32	t	t	PROPN
dti-1375	167	33	su	su	PROPN
dti-1375	167	34	b	b	PROPN
dti-1375	167	35	-g	-g	PROPN
dti-1375	167	36	1	1	NUM
dti-1375	168	1	p	p	NOUN
dti-1375	168	2	o	o	X
dti-1375	168	3	p	p	X
dti-1375	168	4	u	u	X
dti-1375	168	5	la	la	X
dti-1375	168	6	ti	ti	X
dti-1375	168	7	o	o	NOUN
dti-1375	168	8	n	n	CCONJ
dti-1375	168	9	0	0	NUM
dti-1375	168	10	20	20	NUM
dti-1375	168	11	40	40	NUM
dti-1375	168	12	60	60	NUM
dti-1375	168	13	80	80	NUM
dti-1375	168	14	100	100	NUM
dti-1375	168	15	1	1	NUM
dti-1375	168	16	d	d	SYM
dti-1375	168	17	2	2	NUM
dti-1375	168	18	d	d	SYM
dti-1375	168	19	3	3	NUM
dti-1375	168	20	d	d	SYM
dti-1375	168	21	4	4	NUM
dti-1375	168	22	d	d	SYM
dti-1375	168	23	5	5	NUM
dti-1375	168	24	d	d	SYM
dti-1375	168	25	6	6	NUM
dti-1375	168	26	d	d	SYM
dti-1375	168	27	1control	1control	NUM
dti-1375	168	28	2	2	NUM
dti-1375	168	29	3	3	NUM
dti-1375	168	30	4	4	NUM
dti-1375	168	31	5	5	NUM
dti-1375	168	32	6	6	NUM
dti-1375	168	33	days	day	NOUN
dti-1375	168	34	of	of	ADP
dti-1375	168	35	treatment	treatment	NOUN
dti-1375	168	36	p	p	PROPN
dti-1375	168	37	16	16	NUM
dti-1375	168	38	/g	/g	PUNCT
dti-1375	168	39	a	a	DET
dti-1375	168	40	p	p	X
dti-1375	169	1	d	d	X
dti-1375	169	2	h	h	NOUN
dti-1375	169	3	r	r	NOUN
dti-1375	169	4	at	at	ADP
dti-1375	169	5	io	io	PROPN
dti-1375	169	6	0	0	PROPN
dti-1375	169	7	control	control	PROPN
dti-1375	169	8	2	2	NUM
dti-1375	169	9	d2	d2	PROPN
dti-1375	169	10	d	d	ADP
dti-1375	169	11	4	4	NUM
dti-1375	169	12	d4	d4	PROPN
dti-1375	169	13	d	d	NOUN
dti-1375	169	14	dox--17aag	dox--17aag	DET
dti-1375	169	15	17aag	17aag	NOUN
dti-1375	169	16	--	--	PUNCT
dti-1375	169	17	dox	dox	NOUN
dti-1375	169	18	6	6	NUM
dti-1375	169	19	d6	d6	NOUN
dti-1375	169	20	d	d	NOUN
dti-1375	169	21	2	2	NUM
dti-1375	169	22	1	1	NUM
dti-1375	169	23	3	3	NUM
dti-1375	169	24	4	4	NUM
dti-1375	169	25	5	5	NUM
dti-1375	169	26	p	p	NOUN
dti-1375	169	27	21	21	NUM
dti-1375	169	28	/g	/g	PUNCT
dti-1375	169	29	a	a	DET
dti-1375	169	30	p	p	X
dti-1375	170	1	d	d	X
dti-1375	170	2	h	h	NOUN
dti-1375	170	3	r	r	NOUN
dti-1375	170	4	at	at	ADP
dti-1375	170	5	io	io	PROPN
dti-1375	170	6	0	0	PROPN
dti-1375	170	7	control	control	PROPN
dti-1375	170	8	2	2	NUM
dti-1375	170	9	d2	d2	PROPN
dti-1375	170	10	d	d	ADP
dti-1375	170	11	4	4	NUM
dti-1375	170	12	d4	d4	PROPN
dti-1375	170	13	d	d	NOUN
dti-1375	170	14	dox--17aag	dox--17aag	DET
dti-1375	170	15	17aag	17aag	NOUN
dti-1375	170	16	--	--	PUNCT
dti-1375	170	17	dox	dox	NOUN
dti-1375	170	18	6	6	NUM
dti-1375	170	19	d6	d6	NOUN
dti-1375	170	20	d	d	NOUN
dti-1375	170	21	2	2	NUM
dti-1375	170	22	1	1	NUM
dti-1375	170	23	3	3	NUM
dti-1375	170	24	4	4	NUM
dti-1375	170	25	5	5	NUM
dti-1375	170	26	p	p	NOUN
dti-1375	170	27	53	53	NUM
dti-1375	170	28	/g	/g	PUNCT
dti-1375	170	29	a	a	DET
dti-1375	170	30	p	p	X
dti-1375	171	1	d	d	X
dti-1375	171	2	h	h	NOUN
dti-1375	171	3	r	r	NOUN
dti-1375	171	4	at	at	ADP
dti-1375	171	5	io	io	PROPN
dti-1375	171	6	0	0	PROPN
dti-1375	171	7	control	control	PROPN
dti-1375	171	8	2	2	NUM
dti-1375	171	9	d2	d2	PROPN
dti-1375	171	10	d	d	ADP
dti-1375	171	11	4	4	NUM
dti-1375	171	12	d4	d4	PROPN
dti-1375	171	13	d	d	NOUN
dti-1375	171	14	dox--17aag	dox--17aag	DET
dti-1375	171	15	17aag	17aag	NOUN
dti-1375	171	16	--	--	PUNCT
dti-1375	171	17	dox	dox	NOUN
dti-1375	171	18	6	6	NUM
dti-1375	171	19	d6	d6	NOUN
dti-1375	171	20	d	d	NOUN
dti-1375	171	21	2	2	NUM
dti-1375	171	22	1	1	NUM
dti-1375	171	23	3	3	NUM
dti-1375	171	24	4	4	NUM
dti-1375	171	25	5	5	NUM
dti-1375	171	26	g	g	NOUN
dti-1375	171	27	a	a	DET
dti-1375	171	28	p	p	X
dti-1375	171	29	d	d	X
dti-1375	171	30	h	h	NOUN
dti-1375	171	31	/h	/h	NOUN
dti-1375	171	32	sp	sp	ADP
dti-1375	171	33	27	27	NUM
dti-1375	171	34	r	r	NOUN
dti-1375	171	35	at	at	ADP
dti-1375	171	36	io	io	PROPN
dti-1375	171	37	0	0	PROPN
dti-1375	171	38	control	control	PROPN
dti-1375	171	39	2	2	NUM
dti-1375	171	40	d2	d2	PROPN
dti-1375	171	41	d	d	ADP
dti-1375	171	42	4	4	NUM
dti-1375	171	43	d4	d4	PROPN
dti-1375	171	44	d	d	NOUN
dti-1375	171	45	dox--17aag	dox--17aag	DET
dti-1375	171	46	17aag	17aag	NOUN
dti-1375	171	47	--	--	PUNCT
dti-1375	171	48	dox	dox	NOUN
dti-1375	171	49	6	6	NUM
dti-1375	171	50	d6	d6	NOUN
dti-1375	171	51	d	d	NOUN
dti-1375	171	52	2	2	NUM
dti-1375	171	53	1	1	NUM
dti-1375	171	54	3	3	NUM
dti-1375	171	55	4	4	NUM
dti-1375	171	56	5	5	NUM
dti-1375	171	57	h	h	NOUN
dti-1375	171	58	sp	sp	ADP
dti-1375	171	59	70	70	NUM
dti-1375	171	60	/g	/g	PUNCT
dti-1375	171	61	a	a	DET
dti-1375	171	62	p	p	X
dti-1375	172	1	d	d	X
dti-1375	172	2	h	h	NOUN
dti-1375	172	3	r	r	NOUN
dti-1375	172	4	at	at	ADP
dti-1375	172	5	io	io	PROPN
dti-1375	172	6	0	0	PROPN
dti-1375	172	7	control	control	PROPN
dti-1375	172	8	2	2	NUM
dti-1375	172	9	d2	d2	PROPN
dti-1375	172	10	d	d	ADP
dti-1375	172	11	4	4	NUM
dti-1375	172	12	d4	d4	PROPN
dti-1375	172	13	d	d	NOUN
dti-1375	172	14	dox--17aag	dox--17aag	DET
dti-1375	172	15	17aag	17aag	NOUN
dti-1375	172	16	--	--	PUNCT
dti-1375	172	17	dox	dox	NOUN
dti-1375	172	18	6	6	NUM
dti-1375	172	19	d6	d6	NOUN
dti-1375	172	20	d	d	NOUN
dti-1375	172	21	2	2	NUM
dti-1375	172	22	1	1	NUM
dti-1375	172	23	3	3	NUM
dti-1375	172	24	4	4	NUM
dti-1375	172	25	5	5	NUM
dti-1375	172	26	h	h	NOUN
dti-1375	172	27	sp	sp	ADP
dti-1375	172	28	90	90	NUM
dti-1375	172	29	/g	/g	PUNCT
dti-1375	172	30	a	a	DET
dti-1375	172	31	p	p	X
dti-1375	173	1	d	d	X
dti-1375	173	2	h	h	NOUN
dti-1375	173	3	r	r	NOUN
dti-1375	173	4	at	at	ADP
dti-1375	173	5	io	io	PROPN
dti-1375	173	6	0	0	PROPN
dti-1375	173	7	control	control	PROPN
dti-1375	173	8	2	2	NUM
dti-1375	173	9	d2	d2	PROPN
dti-1375	173	10	d	d	ADP
dti-1375	173	11	4	4	NUM
dti-1375	173	12	d4	d4	PROPN
dti-1375	173	13	d	d	NOUN
dti-1375	173	14	dox--17aag	dox--17aag	DET
dti-1375	173	15	17aag	17aag	NOUN
dti-1375	173	16	--	--	PUNCT
dti-1375	173	17	dox	dox	NOUN
dti-1375	173	18	6	6	NUM
dti-1375	173	19	d6	d6	NOUN
dti-1375	173	20	d	d	NOUN
dti-1375	173	21	2	2	NUM
dti-1375	173	22	1	1	NUM
dti-1375	173	23	3	3	NUM
dti-1375	173	24	4	4	NUM
dti-1375	173	25	5	5	NUM
dti-1375	173	26	days	day	NOUN
dti-1375	173	27	hsp27	hsp27	PROPN
dti-1375	173	28	hsp70	hsp70	PROPN
dti-1375	173	29	hsp90	hsp90	PROPN
dti-1375	173	30	gapdh	gapdh	NOUN
dti-1375	173	31	p53	p53	NOUN
dti-1375	173	32	p21	p21	NOUN
dti-1375	173	33	p16	p16	NOUN
dti-1375	173	34	figure	figure	NOUN
dti-1375	173	35	2	2	NUM
dti-1375	173	36	.	.	PUNCT
dti-1375	173	37	effect	effect	NOUN
dti-1375	173	38	of	of	ADP
dti-1375	173	39	pre	pre	NOUN
dti-1375	173	40	-	-	NOUN
dti-1375	173	41	treatments	treatment	NOUN
dti-1375	173	42	on	on	ADP
dti-1375	173	43	imr-32	imr-32	NOUN
dti-1375	173	44	neuroblastoma	neuroblastoma	ADJ
dti-1375	173	45	cells	cell	NOUN
dti-1375	173	46	.	.	PUNCT
dti-1375	174	1	(	(	PUNCT
dti-1375	174	2	a	a	X
dti-1375	174	3	)	)	PUNCT
dti-1375	174	4	sa	sa	PROPN
dti-1375	174	5	-	-	PUNCT
dti-1375	174	6	β	β	NOUN
dti-1375	174	7	-	-	ADJ
dti-1375	174	8	gal	gal	ADJ
dti-1375	174	9	staining	staining	NOUN
dti-1375	174	10	of	of	ADP
dti-1375	174	11	control	control	NOUN
dti-1375	174	12	and	and	CCONJ
dti-1375	174	13	6	6	NUM
dti-1375	174	14	-	-	PUNCT
dti-1375	174	15	day	day	NOUN
dti-1375	174	16	drug	drug	NOUN
dti-1375	174	17	treated	treat	VERB
dti-1375	174	18	cells	cell	NOUN
dti-1375	174	19	.	.	PUNCT
dti-1375	175	1	(	(	PUNCT
dti-1375	175	2	a1	a1	NOUN
dti-1375	175	3	)	)	PUNCT
dti-1375	175	4	statistical	statistical	ADJ
dti-1375	175	5	representation	representation	NOUN
dti-1375	175	6	of	of	ADP
dti-1375	175	7	drug	drug	NOUN
dti-1375	175	8	pre	pre	NOUN
dti-1375	175	9	-	-	ADJ
dti-1375	175	10	treatment	treatment	ADJ
dti-1375	175	11	accelerated	accelerate	VERB
dti-1375	175	12	percent	percent	NOUN
dti-1375	175	13	sa	sa	PROPN
dti-1375	175	14	-	-	PUNCT
dti-1375	175	15	β	β	NOUN
dti-1375	175	16	-	-	ADJ
dti-1375	175	17	gal	gal	ADJ
dti-1375	175	18	positive	positive	ADJ
dti-1375	175	19	cells	cell	NOUN
dti-1375	175	20	.	.	PUNCT
dti-1375	176	1	the	the	DET
dti-1375	176	2	images	image	NOUN
dti-1375	176	3	captured	capture	VERB
dti-1375	176	4	at	at	ADP
dti-1375	176	5	20x	20x	NOUN
dti-1375	176	6	magnification	magnification	NOUN
dti-1375	176	7	(	(	PUNCT
dti-1375	176	8	axiovert	axiovert	NOUN
dti-1375	176	9	200	200	NUM
dti-1375	176	10	,	,	PUNCT
dti-1375	176	11	carl	carl	PROPN
dti-1375	176	12	zeiss	zeiss	PROPN
dti-1375	176	13	)	)	PUNCT
dti-1375	176	14	.	.	PUNCT
dti-1375	177	1	(	(	PUNCT
dti-1375	177	2	b	b	X
dti-1375	177	3	)	)	PUNCT
dti-1375	177	4	percent	percent	NOUN
dti-1375	177	5	cytotoxicity	cytotoxicity	NOUN
dti-1375	177	6	in	in	ADP
dti-1375	177	7	individual	individual	ADJ
dti-1375	177	8	,	,	PUNCT
dti-1375	177	9	combination	combination	NOUN
dti-1375	177	10	and	and	CCONJ
dti-1375	177	11	followed	follow	VERB
dti-1375	177	12	drug	drug	NOUN
dti-1375	177	13	treatments	treatment	NOUN
dti-1375	177	14	measured	measure	VERB
dti-1375	177	15	at	at	ADP
dti-1375	177	16	24	24	NUM
dti-1375	177	17	h	h	NOUN
dti-1375	177	18	time	time	NOUN
dti-1375	177	19	intervals	interval	NOUN
dti-1375	177	20	for	for	ADP
dti-1375	177	21	a	a	DET
dti-1375	177	22	period	period	NOUN
dti-1375	177	23	of	of	ADP
dti-1375	177	24	6	6	NUM
dti-1375	177	25	-	-	PUNCT
dti-1375	177	26	days	day	NOUN
dti-1375	177	27	.	.	PUNCT
dti-1375	178	1	(	(	PUNCT
dti-1375	178	2	c	c	X
dti-1375	178	3	)	)	PUNCT
dti-1375	178	4	accumulation	accumulation	NOUN
dti-1375	178	5	of	of	ADP
dti-1375	178	6	g1	g1	PROPN
dti-1375	178	7	population	population	NOUN
dti-1375	178	8	after	after	ADP
dti-1375	178	9	drug	drug	NOUN
dti-1375	178	10	pre	pre	NOUN
dti-1375	178	11	-	-	NOUN
dti-1375	178	12	treatments	treatment	NOUN
dti-1375	178	13	.	.	PUNCT
dti-1375	179	1	(	(	PUNCT
dti-1375	179	2	d	d	X
dti-1375	179	3	)	)	PUNCT
dti-1375	179	4	rt	rt	ADJ
dti-1375	179	5	-	-	PUNCT
dti-1375	179	6	pcr	pcr	NOUN
dti-1375	179	7	analysis	analysis	NOUN
dti-1375	179	8	of	of	ADP
dti-1375	179	9	gene	gene	NOUN
dti-1375	179	10	expression	expression	NOUN
dti-1375	179	11	profiles	profile	NOUN
dti-1375	179	12	after	after	ADP
dti-1375	179	13	drug	drug	NOUN
dti-1375	179	14	pre	pre	NOUN
dti-1375	179	15	-	-	NOUN
dti-1375	179	16	treatments	treatment	NOUN
dti-1375	179	17	.	.	PUNCT
dti-1375	180	1	(	(	PUNCT
dti-1375	180	2	d1	d1	NOUN
dti-1375	180	3	)	)	PUNCT
dti-1375	180	4	gene	gene	NOUN
dti-1375	180	5	expression	expression	NOUN
dti-1375	180	6	data	datum	NOUN
dti-1375	180	7	was	be	AUX
dti-1375	180	8	used	use	VERB
dti-1375	180	9	to	to	PART
dti-1375	180	10	calculate	calculate	VERB
dti-1375	180	11	the	the	DET
dti-1375	180	12	expression	expression	NOUN
dti-1375	180	13	ratios	ratio	NOUN
dti-1375	180	14	in	in	ADP
dti-1375	180	15	reference	reference	NOUN
dti-1375	180	16	to	to	ADP
dti-1375	180	17	gapdh	gapdh	NOUN
dti-1375	180	18	.	.	PUNCT
dti-1375	181	1	(	(	PUNCT
dti-1375	181	2	e	e	NOUN
dti-1375	181	3	)	)	PUNCT
dti-1375	181	4	immunoblot	immunoblot	VERB
dti-1375	181	5	analysis	analysis	NOUN
dti-1375	181	6	of	of	ADP
dti-1375	181	7	proteins	protein	NOUN
dti-1375	181	8	from	from	ADP
dti-1375	181	9	cell	cell	NOUN
dti-1375	181	10	cycle	cycle	NOUN
dti-1375	181	11	,	,	PUNCT
dti-1375	181	12	hsps	hsps	NOUN
dti-1375	181	13	and	and	CCONJ
dti-1375	181	14	signal	signal	ADJ
dti-1375	181	15	transduction	transduction	NOUN
dti-1375	181	16	.	.	PUNCT
dti-1375	182	1	http://www.la-press.com	http://www.la-press.com	X
dti-1375	183	1	sarangi	sarangi	PROPN
dti-1375	183	2	et	et	PROPN
dti-1375	183	3	al	al	PROPN
dti-1375	183	4	26	26	NUM
dti-1375	183	5	drug	drug	NOUN
dti-1375	183	6	target	target	NOUN
dti-1375	183	7	insights	insight	NOUN
dti-1375	183	8	2012:6	2012:6	NUM
dti-1375	183	9	in	in	ADP
dti-1375	183	10	a	a	DET
dti-1375	183	11	2	2	NUM
dti-1375	183	12	-	-	PUNCT
dti-1375	183	13	day	day	NOUN
dti-1375	183	14	treatment	treatment	NOUN
dti-1375	183	15	but	but	CCONJ
dti-1375	183	16	its	its	PRON
dti-1375	183	17	normalization	normalization	NOUN
dti-1375	183	18	by	by	ADP
dti-1375	183	19	6	6	NUM
dti-1375	183	20	-	-	PUNCT
dti-1375	183	21	day	day	NOUN
dti-1375	183	22	treatment	treatment	NOUN
dti-1375	183	23	.	.	PUNCT
dti-1375	184	1	correlating	correlate	VERB
dti-1375	184	2	with	with	ADP
dti-1375	184	3	increased	increase	VERB
dti-1375	184	4	levels	level	NOUN
dti-1375	184	5	of	of	ADP
dti-1375	184	6	p53	p53	NOUN
dti-1375	184	7	and	and	CCONJ
dti-1375	184	8	p21cip	p21cip	PROPN
dti-1375	184	9	/	/	SYM
dti-1375	184	10	waf-1	waf-1	NUM
dti-1375	184	11	,	,	PUNCT
dti-1375	184	12	a	a	DET
dti-1375	184	13	decrease	decrease	NOUN
dti-1375	184	14	in	in	ADP
dti-1375	184	15	cyclin	cyclin	NOUN
dti-1375	184	16	d1	d1	PROPN
dti-1375	184	17	levels	level	NOUN
dti-1375	184	18	suggested	suggest	VERB
dti-1375	184	19	decreased	decrease	VERB
dti-1375	184	20	proliferation	proliferation	NOUN
dti-1375	184	21	potential	potential	NOUN
dti-1375	184	22	.	.	PUNCT
dti-1375	185	1	in	in	ADP
dti-1375	185	2	contrast	contrast	NOUN
dti-1375	185	3	to	to	ADP
dti-1375	185	4	individual	individual	ADJ
dti-1375	185	5	and	and	CCONJ
dti-1375	185	6	combination	combination	NOUN
dti-1375	185	7	treatments	treatment	NOUN
dti-1375	185	8	,	,	PUNCT
dti-1375	185	9	in	in	ADP
dti-1375	185	10	the	the	DET
dti-1375	185	11	prtreatments	prtreatment	NOUN
dti-1375	185	12	,	,	PUNCT
dti-1375	185	13	a	a	DET
dti-1375	185	14	chronic	chronic	ADJ
dti-1375	185	15	activation	activation	NOUN
dti-1375	185	16	of	of	ADP
dti-1375	185	17	akt	akt	PROPN
dti-1375	185	18	and	and	CCONJ
dti-1375	185	19	erk1/2	erk1/2	PROPN
dti-1375	185	20	kinases	kinase	NOUN
dti-1375	185	21	suggested	suggest	VERB
dti-1375	185	22	maintenance	maintenance	NOUN
dti-1375	185	23	of	of	ADP
dti-1375	185	24	survival	survival	NOUN
dti-1375	185	25	potential	potential	NOUN
dti-1375	185	26	(	(	PUNCT
dti-1375	185	27	fig	fig	NOUN
dti-1375	185	28	.	.	PUNCT
dti-1375	186	1	2e	2e	NUM
dti-1375	186	2	)	)	PUNCT
dti-1375	186	3	.	.	PUNCT
dti-1375	187	1	considering	consider	VERB
dti-1375	187	2	the	the	DET
dti-1375	187	3	accelerated	accelerated	ADJ
dti-1375	187	4	senescence	senescence	NOUN
dti-1375	187	5	with	with	ADP
dti-1375	187	6	17aag	17aag	ADJ
dti-1375	187	7	pre	pre	NOUN
dti-1375	187	8	-	-	NOUN
dti-1375	187	9	treatment	treatment	NOUN
dti-1375	187	10	with	with	ADP
dti-1375	187	11	reduced	reduced	ADJ
dti-1375	187	12	cytotoxicity	cytotoxicity	NOUN
dti-1375	187	13	,	,	PUNCT
dti-1375	187	14	the	the	DET
dti-1375	187	15	subsequent	subsequent	ADJ
dti-1375	187	16	experiments	experiment	NOUN
dti-1375	187	17	were	be	AUX
dti-1375	187	18	performed	perform	VERB
dti-1375	187	19	with	with	ADP
dti-1375	187	20	17aag	17aag	ADJ
dti-1375	187	21	pre	pre	NOUN
dti-1375	187	22	-	-	NOUN
dti-1375	187	23	treatments	treatment	NOUN
dti-1375	187	24	.	.	PUNCT
dti-1375	188	1	17aag	17aag	ADJ
dti-1375	188	2	pre	pre	ADJ
dti-1375	188	3	-	-	NOUN
dti-1375	188	4	treatment	treatment	NOUN
dti-1375	188	5	shows	show	VERB
dti-1375	188	6	typical	typical	ADJ
dti-1375	188	7	features	feature	NOUN
dti-1375	188	8	of	of	ADP
dti-1375	188	9	senescence	senescence	NOUN
dti-1375	188	10	actin	actin	NOUN
dti-1375	188	11	reorganization	reorganization	NOUN
dti-1375	188	12	and	and	CCONJ
dti-1375	188	13	nuclear	nuclear	ADJ
dti-1375	188	14	accumulation	accumulation	NOUN
dti-1375	188	15	was	be	AUX
dti-1375	188	16	proposed	propose	VERB
dti-1375	188	17	as	as	ADP
dti-1375	188	18	an	an	DET
dti-1375	188	19	additional	additional	ADJ
dti-1375	188	20	marker	marker	NOUN
dti-1375	188	21	for	for	ADP
dti-1375	188	22	cellular	cellular	ADJ
dti-1375	188	23	senescence.15	senescence.15	NOUN
dti-1375	188	24	to	to	PART
dti-1375	188	25	understand	understand	VERB
dti-1375	188	26	cellular	cellular	ADJ
dti-1375	188	27	actin	actin	NOUN
dti-1375	188	28	dynamics	dynamic	NOUN
dti-1375	188	29	,	,	PUNCT
dti-1375	188	30	actin	actin	NOUN
dti-1375	188	31	organization	organization	NOUN
dti-1375	188	32	was	be	AUX
dti-1375	188	33	examined	examine	VERB
dti-1375	188	34	in	in	ADP
dti-1375	188	35	17aag	17aag	NOUN
dti-1375	188	36	pretreated	pretreate	VERB
dti-1375	188	37	senescent	senescent	ADJ
dti-1375	188	38	cells	cell	NOUN
dti-1375	188	39	with	with	ADP
dti-1375	188	40	oregon	oregon	PROPN
dti-1375	188	41	green	green	PROPN
dti-1375	188	42	phalloidin	phalloidin	PROPN
dti-1375	188	43	.	.	PUNCT
dti-1375	189	1	compared	compare	VERB
dti-1375	189	2	to	to	ADP
dti-1375	189	3	untreated	untreated	ADJ
dti-1375	189	4	cells	cell	NOUN
dti-1375	189	5	,	,	PUNCT
dti-1375	189	6	senescent	senescent	ADJ
dti-1375	189	7	cells	cell	NOUN
dti-1375	189	8	showed	show	VERB
dti-1375	189	9	a	a	DET
dti-1375	189	10	time	time	NOUN
dti-1375	189	11	dependent	dependent	ADJ
dti-1375	189	12	increase	increase	NOUN
dti-1375	189	13	in	in	ADP
dti-1375	189	14	peripheral	peripheral	ADJ
dti-1375	189	15	actin	actin	NOUN
dti-1375	189	16	bundling	bundling	NOUN
dti-1375	189	17	and	and	CCONJ
dti-1375	189	18	accumulation	accumulation	NOUN
dti-1375	189	19	of	of	ADP
dti-1375	189	20	non	non	ADJ
dti-1375	189	21	-	-	ADJ
dti-1375	189	22	polymerized	polymerized	ADJ
dti-1375	189	23	actin	actin	NOUN
dti-1375	189	24	in	in	ADP
dti-1375	189	25	the	the	DET
dti-1375	189	26	nucleus	nucleus	NOUN
dti-1375	189	27	.	.	PUNCT
dti-1375	190	1	since	since	SCONJ
dti-1375	190	2	sustained	sustain	VERB
dti-1375	190	3	mitochondrial	mitochondrial	ADJ
dti-1375	190	4	functions	function	NOUN
dti-1375	190	5	promote	promote	VERB
dti-1375	190	6	senescence	senescence	NOUN
dti-1375	190	7	activation,16	activation,16	PROPN
dti-1375	190	8	mitochondria	mitochondria	PROPN
dti-1375	190	9	organization	organization	NOUN
dti-1375	190	10	was	be	AUX
dti-1375	190	11	also	also	ADV
dti-1375	190	12	examined	examine	VERB
dti-1375	190	13	with	with	ADP
dti-1375	190	14	mitotracker	mitotracker	PROPN
dti-1375	190	15	red	red	PROPN
dti-1375	190	16	(	(	PUNCT
dti-1375	190	17	cmx	cmx	NOUN
dti-1375	190	18	-	-	PUNCT
dti-1375	190	19	ros	ro	NOUN
dti-1375	190	20	)	)	PUNCT
dti-1375	190	21	.	.	PUNCT
dti-1375	191	1	decreased	decrease	VERB
dti-1375	191	2	actin	actin	NOUN
dti-1375	191	3	bundling	bundle	VERB
dti-1375	191	4	further	far	ADV
dti-1375	191	5	correlating	correlate	VERB
dti-1375	191	6	with	with	ADP
dti-1375	191	7	increased	increase	VERB
dti-1375	191	8	mitochondria	mitochondria	NOUN
dti-1375	191	9	suggested	suggest	VERB
dti-1375	191	10	conventional	conventional	ADJ
dti-1375	191	11	senescence	senescence	NOUN
dti-1375	191	12	activation	activation	NOUN
dti-1375	191	13	(	(	PUNCT
dti-1375	191	14	fig	fig	NOUN
dti-1375	191	15	.	.	PUNCT
dti-1375	192	1	3a	3a	NUM
dti-1375	192	2	)	)	PUNCT
dti-1375	192	3	.	.	PUNCT
dti-1375	193	1	increased	increase	VERB
dti-1375	193	2	intracellular	intracellular	ADJ
dti-1375	193	3	granularity	granularity	NOUN
dti-1375	193	4	is	be	AUX
dti-1375	193	5	considered	consider	VERB
dti-1375	193	6	as	as	SCONJ
dti-1375	193	7	another	another	DET
dti-1375	193	8	characteristic	characteristic	ADJ
dti-1375	193	9	feature	feature	NOUN
dti-1375	193	10	of	of	ADP
dti-1375	193	11	senescent	senescent	ADJ
dti-1375	193	12	cells,17	cells,17	NOUN
dti-1375	193	13	cells	cell	NOUN
dti-1375	193	14	were	be	AUX
dti-1375	193	15	analyzed	analyze	VERB
dti-1375	193	16	for	for	ADP
dti-1375	193	17	forward	forward	ADJ
dti-1375	193	18	scatter	scatter	NOUN
dti-1375	193	19	(	(	PUNCT
dti-1375	193	20	fsc	fsc	PROPN
dti-1375	193	21	)	)	PUNCT
dti-1375	193	22	vs.	vs.	ADP
dti-1375	193	23	side	side	NOUN
dti-1375	193	24	scatter	scatter	NOUN
dti-1375	193	25	(	(	PUNCT
dti-1375	193	26	ssc	ssc	PROPN
dti-1375	193	27	)	)	PUNCT
dti-1375	193	28	by	by	ADP
dti-1375	193	29	facs	fac	NOUN
dti-1375	193	30	.	.	PUNCT
dti-1375	194	1	we	we	PRON
dti-1375	194	2	did	do	AUX
dti-1375	194	3	not	not	PART
dti-1375	194	4	observe	observe	VERB
dti-1375	194	5	any	any	DET
dti-1375	194	6	change	change	NOUN
dti-1375	194	7	in	in	ADP
dti-1375	194	8	fsc	fsc	PROPN
dti-1375	194	9	that	that	PRON
dti-1375	194	10	provide	provide	VERB
dti-1375	194	11	information	information	NOUN
dti-1375	194	12	on	on	ADP
dti-1375	194	13	particle	particle	NOUN
dti-1375	194	14	size	size	NOUN
dti-1375	194	15	but	but	CCONJ
dti-1375	194	16	observed	observe	VERB
dti-1375	194	17	a	a	DET
dti-1375	194	18	gradual	gradual	ADJ
dti-1375	194	19	increase	increase	NOUN
dti-1375	194	20	in	in	ADP
dti-1375	194	21	ssc	ssc	NOUN
dti-1375	194	22	that	that	PRON
dti-1375	194	23	indicate	indicate	VERB
dti-1375	194	24	increased	increase	VERB
dti-1375	194	25	intracellular	intracellular	ADJ
dti-1375	194	26	granularity	granularity	NOUN
dti-1375	194	27	(	(	PUNCT
dti-1375	194	28	fig	fig	NOUN
dti-1375	194	29	.	.	PUNCT
dti-1375	195	1	3b	3b	NUM
dti-1375	195	2	)	)	PUNCT
dti-1375	195	3	.	.	PUNCT
dti-1375	196	1	accumulation	accumulation	NOUN
dti-1375	196	2	of	of	ADP
dti-1375	196	3	cells	cell	NOUN
dti-1375	196	4	in	in	ADP
dti-1375	196	5	g1	g1	PROPN
dti-1375	196	6	though	though	SCONJ
dti-1375	196	7	suggested	suggest	VERB
dti-1375	196	8	replicative	replicative	ADJ
dti-1375	196	9	senescence	senescence	NOUN
dti-1375	196	10	,	,	PUNCT
dti-1375	196	11	involvement	involvement	NOUN
dti-1375	196	12	of	of	ADP
dti-1375	196	13	p53p21cip	p53p21cip	PROPN
dti-1375	196	14	/	/	SYM
dti-1375	196	15	waf-1	waf-1	NUM
dti-1375	196	16	pathway	pathway	NOUN
dti-1375	196	17	highlighted	highlight	VERB
dti-1375	196	18	stress	stress	NOUN
dti-1375	196	19	induced	induce	VERB
dti-1375	196	20	senescence	senescence	NOUN
dti-1375	196	21	.	.	PUNCT
dti-1375	197	1	to	to	PART
dti-1375	197	2	further	far	ADV
dti-1375	197	3	distinguish	distinguish	VERB
dti-1375	197	4	the	the	DET
dti-1375	197	5	mode	mode	NOUN
dti-1375	197	6	of	of	ADP
dti-1375	197	7	senescence	senescence	NOUN
dti-1375	197	8	on	on	ADP
dti-1375	197	9	17aag	17aag	ADJ
dti-1375	197	10	pre	pre	NOUN
dti-1375	197	11	-	-	NOUN
dti-1375	197	12	treatment	treatment	ADJ
dti-1375	197	13	,	,	PUNCT
dti-1375	197	14	telomerase	telomerase	NOUN
dti-1375	197	15	activity	activity	NOUN
dti-1375	197	16	was	be	AUX
dti-1375	197	17	measured	measure	VERB
dti-1375	197	18	from	from	ADP
dti-1375	197	19	senescent	senescent	ADJ
dti-1375	197	20	cells	cell	NOUN
dti-1375	197	21	.	.	PUNCT
dti-1375	198	1	a	a	DET
dti-1375	198	2	small	small	ADJ
dti-1375	198	3	increase	increase	NOUN
dti-1375	198	4	in	in	ADP
dti-1375	198	5	telomerase	telomerase	NOUN
dti-1375	198	6	activity	activity	NOUN
dti-1375	198	7	and	and	CCONJ
dti-1375	198	8	its	its	PRON
dti-1375	198	9	stabilization	stabilization	NOUN
dti-1375	198	10	after	after	ADP
dti-1375	198	11	2	2	NUM
dti-1375	198	12	-	-	PUNCT
dti-1375	198	13	day	day	NOUN
dti-1375	198	14	treatment	treatment	NOUN
dti-1375	198	15	suggested	suggest	VERB
dti-1375	198	16	cellular	cellular	ADJ
dti-1375	198	17	attempt	attempt	NOUN
dti-1375	198	18	to	to	PART
dti-1375	198	19	bypass	bypass	VERB
dti-1375	198	20	senescence	senescence	NOUN
dti-1375	198	21	reprogramming	reprogramming	NOUN
dti-1375	198	22	(	(	PUNCT
dti-1375	198	23	fig	fig	NOUN
dti-1375	198	24	.	.	PUNCT
dti-1375	199	1	3c	3c	NUM
dti-1375	199	2	)	)	PUNCT
dti-1375	199	3	,	,	PUNCT
dti-1375	199	4	which	which	PRON
dti-1375	199	5	is	be	AUX
dti-1375	199	6	a	a	DET
dti-1375	199	7	characteristic	characteristic	ADJ
dti-1375	199	8	feature	feature	NOUN
dti-1375	199	9	of	of	ADP
dti-1375	199	10	cancer	cancer	NOUN
dti-1375	199	11	cells.18	cells.18	VERB
dti-1375	199	12	while	while	SCONJ
dti-1375	199	13	h3k4me3	h3k4me3	NOUN
dti-1375	199	14	marks	mark	NOUN
dti-1375	199	15	transcription	transcription	NOUN
dti-1375	199	16	start	start	VERB
dti-1375	199	17	sites	site	NOUN
dti-1375	199	18	of	of	ADP
dti-1375	199	19	active	active	ADJ
dti-1375	199	20	genes,19	genes,19	ADJ
dti-1375	199	21	senescence	senescence	NOUN
dti-1375	199	22	associated	associate	VERB
dti-1375	199	23	heterochromatin	heterochromatin	NOUN
dti-1375	199	24	foci	focus	NOUN
dti-1375	199	25	(	(	PUNCT
dti-1375	199	26	sahf	sahf	NOUN
dti-1375	199	27	)	)	PUNCT
dti-1375	199	28	marks	mark	VERB
dti-1375	199	29	dna	dna	PROPN
dti-1375	199	30	damage	damage	NOUN
dti-1375	199	31	response	response	NOUN
dti-1375	199	32	(	(	PUNCT
dti-1375	199	33	ddr	ddr	NOUN
dti-1375	199	34	)	)	PUNCT
dti-1375	199	35	to	to	ADP
dti-1375	199	36	senescence.20	senescence.20	NOUN
dti-1375	199	37	the	the	DET
dti-1375	199	38	cytoimmunofluorescence	cytoimmunofluorescence	NOUN
dti-1375	199	39	analyses	analysis	NOUN
dti-1375	199	40	of	of	ADP
dti-1375	199	41	γh2ax	γh2ax	PROPN
dti-1375	199	42	(	(	PUNCT
dti-1375	199	43	for	for	ADP
dti-1375	199	44	sahf	sahf	NOUN
dti-1375	199	45	)	)	PUNCT
dti-1375	199	46	and	and	CCONJ
dti-1375	199	47	h3k4me3	h3k4me3	PROPN
dti-1375	199	48	showed	show	VERB
dti-1375	199	49	a	a	DET
dti-1375	199	50	gradual	gradual	ADJ
dti-1375	199	51	increase	increase	NOUN
dti-1375	199	52	in	in	ADP
dti-1375	199	53	sahf	sahf	NOUN
dti-1375	199	54	but	but	CCONJ
dti-1375	199	55	cytosolic	cytosolic	ADJ
dti-1375	199	56	accumulation	accumulation	NOUN
dti-1375	199	57	of	of	ADP
dti-1375	199	58	h3k4me3	h3k4me3	PROPN
dti-1375	199	59	(	(	PUNCT
dti-1375	199	60	fig	fig	NOUN
dti-1375	199	61	.	.	PUNCT
dti-1375	200	1	3d	3d	NOUN
dti-1375	200	2	and	and	CCONJ
dti-1375	200	3	e	e	NOUN
dti-1375	200	4	respectively	respectively	ADV
dti-1375	200	5	)	)	PUNCT
dti-1375	200	6	.	.	PUNCT
dti-1375	201	1	telomerase	telomerase	NOUN
dti-1375	201	2	activity	activity	NOUN
dti-1375	201	3	is	be	AUX
dti-1375	201	4	linked	link	VERB
dti-1375	201	5	to	to	ADP
dti-1375	201	6	p16ink4a,21	p16ink4a,21	NOUN
dti-1375	201	7	however	however	ADV
dti-1375	201	8	,	,	PUNCT
dti-1375	201	9	neuroblastoma	neuroblastoma	ADJ
dti-1375	201	10	exhibit	exhibit	NOUN
dti-1375	201	11	chronic	chronic	ADJ
dti-1375	201	12	p16ink4a	p16ink4a	NOUN
dti-1375	201	13	expression	expression	NOUN
dti-1375	201	14	(	(	PUNCT
dti-1375	201	15	fig	fig	NOUN
dti-1375	201	16	.	.	PUNCT
dti-1375	201	17	1b	1b	NUM
dti-1375	201	18	)	)	PUNCT
dti-1375	201	19	,	,	PUNCT
dti-1375	201	20	which	which	PRON
dti-1375	201	21	is	be	AUX
dti-1375	201	22	thought	think	VERB
dti-1375	201	23	to	to	PART
dti-1375	201	24	bypass	bypass	VERB
dti-1375	201	25	senescence	senescence	NOUN
dti-1375	201	26	programming.22	programming.22	NOUN
dti-1375	201	27	to	to	PART
dti-1375	201	28	examine	examine	VERB
dti-1375	201	29	p16ink4a	p16ink4a	NOUN
dti-1375	201	30	cellular	cellular	ADJ
dti-1375	201	31	distribution	distribution	NOUN
dti-1375	201	32	,	,	PUNCT
dti-1375	201	33	we	we	PRON
dti-1375	201	34	performed	perform	VERB
dti-1375	201	35	cytoimmunoflourescence	cytoimmunoflourescence	NOUN
dti-1375	201	36	.	.	PUNCT
dti-1375	202	1	although	although	SCONJ
dti-1375	202	2	,	,	PUNCT
dti-1375	202	3	there	there	PRON
dti-1375	202	4	was	be	VERB
dti-1375	202	5	an	an	DET
dti-1375	202	6	increase	increase	NOUN
dti-1375	202	7	in	in	ADP
dti-1375	202	8	nuclear	nuclear	ADJ
dti-1375	202	9	distribution	distribution	NOUN
dti-1375	202	10	in	in	ADP
dti-1375	202	11	2	2	NUM
dti-1375	202	12	-	-	PUNCT
dti-1375	202	13	day	day	NOUN
dti-1375	202	14	treatment	treatment	NOUN
dti-1375	202	15	,	,	PUNCT
dti-1375	202	16	which	which	PRON
dti-1375	202	17	has	have	AUX
dti-1375	202	18	significantly	significantly	ADV
dti-1375	202	19	decreased	decrease	VERB
dti-1375	202	20	in	in	ADP
dti-1375	202	21	4and	4and	NUM
dti-1375	202	22	6	6	NUM
dti-1375	202	23	-	-	PUNCT
dti-1375	202	24	day	day	NOUN
dti-1375	202	25	treatments	treatment	NOUN
dti-1375	202	26	invalidating	invalidate	VERB
dti-1375	202	27	its	its	PRON
dti-1375	202	28	role	role	NOUN
dti-1375	202	29	in	in	ADP
dti-1375	202	30	senescence	senescence	NOUN
dti-1375	202	31	activation	activation	NOUN
dti-1375	202	32	(	(	PUNCT
dti-1375	202	33	fig	fig	NOUN
dti-1375	202	34	.	.	PUNCT
dti-1375	202	35	3f	3f	PROPN
dti-1375	202	36	)	)	PUNCT
dti-1375	202	37	.	.	PUNCT
dti-1375	203	1	17aag	17aag	ADJ
dti-1375	203	2	pre	pre	ADJ
dti-1375	203	3	-	-	ADJ
dti-1375	203	4	treatment	treatment	NOUN
dti-1375	203	5	induced	induced	ADJ
dti-1375	203	6	[	[	PUNCT
dti-1375	203	7	(	(	PUNCT
dti-1375	203	8	ros)i	ros)i	NOUN
dti-1375	203	9	]	]	PUNCT
dti-1375	203	10	and	and	CCONJ
dti-1375	203	11	[	[	X
dti-1375	203	12	(	(	PUNCT
dti-1375	203	13	ca2+)i	ca2+)i	NOUN
dti-1375	203	14	]	]	PUNCT
dti-1375	203	15	promotes	promote	VERB
dti-1375	203	16	senescence	senescence	NOUN
dti-1375	203	17	and	and	CCONJ
dti-1375	203	18	autophagy	autophagy	NOUN
dti-1375	203	19	calcium	calcium	NOUN
dti-1375	203	20	permeation	permeation	NOUN
dti-1375	203	21	across	across	ADP
dti-1375	203	22	membranes	membrane	NOUN
dti-1375	203	23	and	and	CCONJ
dti-1375	203	24	mobilization	mobilization	NOUN
dti-1375	203	25	from	from	ADP
dti-1375	203	26	organelles	organelle	NOUN
dti-1375	203	27	was	be	AUX
dti-1375	203	28	associated	associate	VERB
dti-1375	203	29	with	with	ADP
dti-1375	203	30	senescence23	senescence23	NOUN
dti-1375	203	31	along	along	ADP
dti-1375	203	32	with	with	ADP
dti-1375	203	33	increased	increase	VERB
dti-1375	203	34	[	[	X
dti-1375	203	35	(	(	PUNCT
dti-1375	203	36	ros)i].24	ros)i].24	NOUN
dti-1375	203	37	we	we	PRON
dti-1375	203	38	measured	measure	VERB
dti-1375	203	39	[	[	X
dti-1375	203	40	(	(	PUNCT
dti-1375	203	41	ca2+)i	ca2+)i	NOUN
dti-1375	203	42	]	]	PUNCT
dti-1375	203	43	and	and	CCONJ
dti-1375	203	44	[	[	X
dti-1375	203	45	(	(	PUNCT
dti-1375	203	46	ros)i	ros)i	PROPN
dti-1375	203	47	]	]	PUNCT
dti-1375	203	48	levels	level	NOUN
dti-1375	203	49	by	by	ADP
dti-1375	203	50	facs	fac	NOUN
dti-1375	203	51	.	.	PUNCT
dti-1375	204	1	in	in	ADP
dti-1375	204	2	comparison	comparison	NOUN
dti-1375	204	3	with	with	ADP
dti-1375	204	4	the	the	DET
dti-1375	204	5	control	control	NOUN
dti-1375	204	6	,	,	PUNCT
dti-1375	204	7	we	we	PRON
dti-1375	204	8	observed	observe	VERB
dti-1375	204	9	an	an	DET
dti-1375	204	10	initial	initial	ADJ
dti-1375	204	11	increase	increase	NOUN
dti-1375	204	12	in	in	ADP
dti-1375	204	13	[	[	X
dti-1375	204	14	(	(	PUNCT
dti-1375	204	15	ca2+)i	ca2+)i	NOUN
dti-1375	204	16	]	]	PUNCT
dti-1375	204	17	levels	level	NOUN
dti-1375	204	18	by	by	ADP
dti-1375	204	19	24.7	24.7	NUM
dti-1375	204	20	folds	fold	NOUN
dti-1375	204	21	in	in	ADP
dti-1375	204	22	2	2	NUM
dti-1375	204	23	-	-	PUNCT
dti-1375	204	24	day	day	NOUN
dti-1375	204	25	treatment	treatment	NOUN
dti-1375	204	26	,	,	PUNCT
dti-1375	204	27	which	which	PRON
dti-1375	204	28	was	be	AUX
dti-1375	204	29	decreased	decrease	VERB
dti-1375	204	30	by	by	ADP
dti-1375	204	31	17.3	17.3	NUM
dti-1375	204	32	folds	fold	NOUN
dti-1375	204	33	and	and	CCONJ
dti-1375	204	34	18.1	18.1	NUM
dti-1375	204	35	folds	fold	NOUN
dti-1375	204	36	by	by	ADP
dti-1375	204	37	day-4	day-4	PUNCT
dti-1375	204	38	and	and	CCONJ
dti-1375	204	39	day-6	day-6	PUNCT
dti-1375	204	40	treatments	treatment	NOUN
dti-1375	204	41	(	(	PUNCT
dti-1375	204	42	fig	fig	NOUN
dti-1375	204	43	.	.	PUNCT
dti-1375	205	1	4a	4a	NOUN
dti-1375	205	2	,	,	PUNCT
dti-1375	205	3	p	p	NOUN
dti-1375	205	4	,	,	PUNCT
dti-1375	205	5	0.001	0.001	NUM
dti-1375	205	6	)	)	PUNCT
dti-1375	205	7	.	.	PUNCT
dti-1375	206	1	there	there	PRON
dti-1375	206	2	was	be	VERB
dti-1375	206	3	also	also	ADV
dti-1375	206	4	a	a	DET
dti-1375	206	5	gradual	gradual	ADJ
dti-1375	206	6	increase	increase	NOUN
dti-1375	206	7	in	in	ADP
dti-1375	206	8	[	[	X
dti-1375	206	9	(	(	PUNCT
dti-1375	206	10	ros)i	ros)i	PROPN
dti-1375	206	11	]	]	PUNCT
dti-1375	206	12	levels	level	NOUN
dti-1375	206	13	by	by	ADP
dti-1375	206	14	2.6	2.6	NUM
dti-1375	206	15	,	,	PUNCT
dti-1375	206	16	16.8	16.8	NUM
dti-1375	206	17	and	and	CCONJ
dti-1375	206	18	42.7	42.7	NUM
dti-1375	206	19	folds	fold	NOUN
dti-1375	206	20	for	for	ADP
dti-1375	206	21	day-2	day-2	NOUN
dti-1375	206	22	,	,	PUNCT
dti-1375	206	23	-4	-4	PUNCT
dti-1375	206	24	and	and	CCONJ
dti-1375	206	25	-6	-6	ADV
dti-1375	206	26	respectively	respectively	ADV
dti-1375	206	27	(	(	PUNCT
dti-1375	206	28	fig	fig	NOUN
dti-1375	206	29	.	.	PUNCT
dti-1375	207	1	4b	4b	PROPN
dti-1375	207	2	,	,	PUNCT
dti-1375	207	3	p	p	NOUN
dti-1375	207	4	,	,	PUNCT
dti-1375	207	5	0.05	0.05	NUM
dti-1375	207	6	)	)	PUNCT
dti-1375	207	7	.	.	PUNCT
dti-1375	208	1	mitochondria	mitochondria	PROPN
dti-1375	208	2	being	be	AUX
dti-1375	208	3	the	the	DET
dti-1375	208	4	major	major	ADJ
dti-1375	208	5	source	source	NOUN
dti-1375	208	6	of	of	ADP
dti-1375	208	7	[	[	X
dti-1375	208	8	(	(	PUNCT
dti-1375	208	9	ros)i	ros)i	NOUN
dti-1375	208	10	]	]	PUNCT
dti-1375	208	11	and	and	CCONJ
dti-1375	208	12	the	the	DET
dti-1375	208	13	∆ψm	∆ψm	NOUN
dti-1375	208	14	is	be	AUX
dti-1375	208	15	considered	consider	VERB
dti-1375	208	16	to	to	PART
dti-1375	208	17	be	be	AUX
dti-1375	208	18	a	a	DET
dti-1375	208	19	biomarker	biomarker	NOUN
dti-1375	208	20	for	for	ADP
dti-1375	208	21	oxidative	oxidative	ADJ
dti-1375	208	22	stress,25	stress,25	NOUN
dti-1375	208	23	the	the	DET
dti-1375	208	24	∆ψm	∆ψm	NOUN
dti-1375	208	25	was	be	AUX
dti-1375	208	26	measured	measure	VERB
dti-1375	208	27	by	by	ADP
dti-1375	208	28	facs	fac	NOUN
dti-1375	208	29	.	.	PUNCT
dti-1375	209	1	a	a	DET
dti-1375	209	2	gradual	gradual	ADJ
dti-1375	209	3	increase	increase	NOUN
dti-1375	209	4	in	in	ADP
dti-1375	209	5	negative	negative	ADJ
dti-1375	209	6	polarization	polarization	NOUN
dti-1375	209	7	of	of	ADP
dti-1375	209	8	mitochondria	mitochondria	NOUN
dti-1375	209	9	observed	observe	VERB
dti-1375	209	10	until	until	ADP
dti-1375	209	11	4	4	NUM
dti-1375	209	12	-	-	PUNCT
dti-1375	209	13	day	day	NOUN
dti-1375	209	14	time	time	NOUN
dti-1375	209	15	interval	interval	NOUN
dti-1375	209	16	though	though	SCONJ
dti-1375	209	17	suggested	suggest	VERB
dti-1375	209	18	oxidative	oxidative	ADJ
dti-1375	209	19	damage	damage	NOUN
dti-1375	209	20	;	;	PUNCT
dti-1375	209	21	a	a	DET
dti-1375	209	22	decrease	decrease	NOUN
dti-1375	209	23	by	by	ADP
dti-1375	209	24	6	6	NUM
dti-1375	209	25	-	-	PUNCT
dti-1375	209	26	day	day	NOUN
dti-1375	209	27	treatment	treatment	NOUN
dti-1375	209	28	suggests	suggest	VERB
dti-1375	209	29	recovery	recovery	NOUN
dti-1375	209	30	from	from	ADP
dti-1375	209	31	the	the	DET
dti-1375	209	32	oxidative	oxidative	ADJ
dti-1375	209	33	stress	stress	NOUN
dti-1375	209	34	(	(	PUNCT
dti-1375	209	35	fig	fig	NOUN
dti-1375	209	36	.	.	PUNCT
dti-1375	210	1	4c	4c	NOUN
dti-1375	210	2	,	,	PUNCT
dti-1375	210	3	p	p	X
dti-1375	210	4	,	,	PUNCT
dti-1375	210	5	0.05	0.05	NUM
dti-1375	210	6	)	)	PUNCT
dti-1375	210	7	.	.	PUNCT
dti-1375	211	1	since	since	SCONJ
dti-1375	211	2	oxidative	oxidative	ADJ
dti-1375	211	3	stress	stress	NOUN
dti-1375	211	4	is	be	AUX
dti-1375	211	5	caused	cause	VERB
dti-1375	211	6	by	by	ADP
dti-1375	211	7	the	the	DET
dti-1375	211	8	imbalance	imbalance	NOUN
dti-1375	211	9	between	between	ADP
dti-1375	211	10	[	[	X
dti-1375	211	11	(	(	PUNCT
dti-1375	211	12	ros)i	ros)i	NOUN
dti-1375	211	13	]	]	PUNCT
dti-1375	211	14	and	and	CCONJ
dti-1375	211	15	impairment	impairment	NOUN
dti-1375	211	16	of	of	ADP
dti-1375	211	17	antioxidative	antioxidative	ADJ
dti-1375	211	18	enzyme	enzyme	NOUN
dti-1375	211	19	system,26	system,26	NOUN
dti-1375	211	20	we	we	PRON
dti-1375	211	21	examined	examine	VERB
dti-1375	211	22	the	the	DET
dti-1375	211	23	status	status	NOUN
dti-1375	211	24	of	of	ADP
dti-1375	211	25	antioxidative	antioxidative	ADJ
dti-1375	211	26	enzymes	enzyme	NOUN
dti-1375	211	27	,	,	PUNCT
dti-1375	211	28	superoxide	superoxide	NOUN
dti-1375	211	29	dismutases	dismutase	NOUN
dti-1375	211	30	,	,	PUNCT
dti-1375	211	31	sod1	sod1	ADJ
dti-1375	211	32	(	(	PUNCT
dti-1375	211	33	cuzn	cuzn	NOUN
dti-1375	211	34	sod	sod	NOUN
dti-1375	211	35	,	,	PUNCT
dti-1375	211	36	cytoplasmic	cytoplasmic	NOUN
dti-1375	211	37	)	)	PUNCT
dti-1375	211	38	,	,	PUNCT
dti-1375	211	39	sod2	sod2	PROPN
dti-1375	211	40	(	(	PUNCT
dti-1375	211	41	mnsod	mnsod	ADJ
dti-1375	211	42	,	,	PUNCT
dti-1375	211	43	mitochondrial	mitochondrial	ADJ
dti-1375	211	44	)	)	PUNCT
dti-1375	211	45	and	and	CCONJ
dti-1375	211	46	catalase	catalase	NOUN
dti-1375	211	47	(	(	PUNCT
dti-1375	211	48	peroxisomes	peroxisome	NOUN
dti-1375	211	49	)	)	PUNCT
dti-1375	211	50	in	in	ADP
dti-1375	211	51	both	both	CCONJ
dti-1375	211	52	doxorubicin	doxorubicin	PROPN
dti-1375	211	53	and	and	CCONJ
dti-1375	211	54	17aag	17aag	ADJ
dti-1375	211	55	pre	pre	NOUN
dti-1375	211	56	-	-	NOUN
dti-1375	211	57	treatments	treatment	NOUN
dti-1375	211	58	by	by	ADP
dti-1375	211	59	immunoblot	immunoblot	NOUN
dti-1375	211	60	analysis	analysis	NOUN
dti-1375	211	61	.	.	PUNCT
dti-1375	212	1	the	the	DET
dti-1375	212	2	induced	induced	ADJ
dti-1375	212	3	levels	level	NOUN
dti-1375	212	4	of	of	ADP
dti-1375	212	5	sod1	sod1	NOUN
dti-1375	212	6	,	,	PUNCT
dti-1375	212	7	sod2	sod2	NOUN
dti-1375	212	8	and	and	CCONJ
dti-1375	212	9	decreased	decrease	VERB
dti-1375	212	10	levels	level	NOUN
dti-1375	212	11	of	of	ADP
dti-1375	212	12	catalase	catalase	NOUN
dti-1375	212	13	on	on	ADP
dti-1375	212	14	both	both	CCONJ
dti-1375	212	15	the	the	DET
dti-1375	212	16	pre	pre	NOUN
dti-1375	212	17	-	-	NOUN
dti-1375	212	18	treatments	treatment	NOUN
dti-1375	212	19	suggested	suggest	VERB
dti-1375	212	20	activation	activation	NOUN
dti-1375	212	21	of	of	ADP
dti-1375	212	22	intracellular	intracellular	ADJ
dti-1375	212	23	antioxidative	antioxidative	ADJ
dti-1375	212	24	defense	defense	NOUN
dti-1375	212	25	,	,	PUNCT
dti-1375	212	26	which	which	PRON
dti-1375	212	27	also	also	ADV
dti-1375	212	28	advocates	advocate	VERB
dti-1375	212	29	non	non	ADJ
dti-1375	212	30	-	-	ADJ
dti-1375	212	31	lethal	lethal	ADJ
dti-1375	212	32	level	level	NOUN
dti-1375	212	33	production	production	NOUN
dti-1375	212	34	of	of	ADP
dti-1375	212	35	[	[	X
dti-1375	212	36	(	(	PUNCT
dti-1375	212	37	ros)i	ros)i	X
dti-1375	212	38	]	]	X
dti-1375	212	39	(	(	PUNCT
dti-1375	212	40	fig	fig	NOUN
dti-1375	212	41	.	.	PUNCT
dti-1375	212	42	4d	4d	NUM
dti-1375	212	43	)	)	PUNCT
dti-1375	212	44	.	.	PUNCT
dti-1375	213	1	the	the	DET
dti-1375	213	2	gene	gene	NOUN
dti-1375	213	3	expression	expression	NOUN
dti-1375	213	4	analyzed	analyze	VERB
dti-1375	213	5	by	by	ADP
dti-1375	213	6	image	image	NOUN
dti-1375	213	7	j	j	PROPN
dti-1375	213	8	and	and	CCONJ
dti-1375	213	9	represented	represent	VERB
dti-1375	213	10	as	as	ADP
dti-1375	213	11	gene	gene	NOUN
dti-1375	213	12	http://www.la-press.com	http://www.la-press.com	X
dti-1375	214	1	hsp90	hsp90	ADJ
dti-1375	214	2	inhibition	inhibition	NOUN
dti-1375	214	3	accelerates	accelerate	VERB
dti-1375	214	4	senescence	senescence	NOUN
dti-1375	214	5	drug	drug	NOUN
dti-1375	214	6	target	target	NOUN
dti-1375	214	7	insights	insight	NOUN
dti-1375	214	8	2012:6	2012:6	NUM
dti-1375	214	9	27	27	NUM
dti-1375	214	10	cmx	cmx	NOUN
dti-1375	214	11	-	-	PUNCT
dti-1375	214	12	ros	ros	ADJ
dti-1375	214	13	control	control	NOUN
dti-1375	214	14	2	2	NUM
dti-1375	214	15	d	d	SYM
dti-1375	214	16	4	4	NUM
dti-1375	214	17	d	d	SYM
dti-1375	214	18	6	6	NUM
dti-1375	214	19	d	d	SYM
dti-1375	214	20	0.0	0.0	NUM
dti-1375	214	21	control	control	NOUN
dti-1375	214	22	2	2	NUM
dti-1375	214	23	d	d	SYM
dti-1375	214	24	4	4	NUM
dti-1375	214	25	d	d	NOUN
dti-1375	214	26	p	p	X
dti-1375	214	27	<	<	X
dti-1375	214	28	0.001	0.001	NUM
dti-1375	214	29	treatment	treatment	NOUN
dti-1375	214	30	in	in	ADP
dti-1375	214	31	days	day	NOUN
dti-1375	214	32	r	r	NOUN
dti-1375	214	33	ea	ea	PROPN
dti-1375	214	34	lti	lti	PROPN
dti-1375	214	35	m	m	PROPN
dti-1375	214	36	e	e	X
dti-1375	214	37	th	th	X
dti-1375	214	38	re	re	ADP
dti-1375	214	39	sh	sh	PROPN
dti-1375	214	40	o	o	INTJ
dti-1375	214	41	ld	ld	PROPN
dti-1375	214	42	(	(	PUNCT
dti-1375	214	43	c	c	NOUN
dti-1375	214	44	t	t	PROPN
dti-1375	214	45	)	)	PUNCT
dti-1375	214	46	5	5	NUM
dti-1375	214	47	d	d	PROPN
dti-1375	214	48	5.00	5.00	NUM
dti-1375	214	49	10.00	10.00	NUM
dti-1375	214	50	15.00	15.00	NUM
dti-1375	214	51	20.00	20.00	NUM
dti-1375	214	52	25.00	25.00	NUM
dti-1375	214	53	control	control	NOUN
dti-1375	214	54	2	2	NUM
dti-1375	214	55	d	d	SYM
dti-1375	214	56	4	4	NUM
dti-1375	214	57	d	d	SYM
dti-1375	214	58	6	6	NUM
dti-1375	214	59	d	d	NOUN
dti-1375	214	60	control	control	NOUN
dti-1375	214	61	2	2	NUM
dti-1375	214	62	d	d	SYM
dti-1375	214	63	4	4	NUM
dti-1375	214	64	d	d	SYM
dti-1375	214	65	6	6	NUM
dti-1375	214	66	d	d	SYM
dti-1375	214	67	6	6	NUM
dti-1375	214	68	d	d	PROPN
dti-1375	214	69	oregon	oregon	PROPN
dti-1375	214	70	green	green	PROPN
dti-1375	214	71	phalloidin	phalloidin	PROPN
dti-1375	214	72	dapi	dapi	ADJ
dti-1375	214	73	merge	merge	NOUN
dti-1375	214	74	dapiγh2ax	dapiγh2ax	PRON
dti-1375	214	75	merge	merge	NOUN
dti-1375	214	76	dapip16	dapip16	NOUN
dti-1375	214	77	merge	merge	VERB
dti-1375	214	78	control	control	NOUN
dti-1375	214	79	2	2	NUM
dti-1375	214	80	d	d	SYM
dti-1375	214	81	4	4	NUM
dti-1375	214	82	d	d	SYM
dti-1375	214	83	6	6	NUM
dti-1375	215	1	d	d	NOUN
dti-1375	215	2	dapi	dapi	PROPN
dti-1375	216	1	trimethyl	trimethyl	PROPN
dti-1375	216	2	histone	histone	NOUN
dti-1375	216	3	merge	merge	VERB
dti-1375	216	4	17a	17a	PROPN
dti-1375	216	5	a	a	DET
dti-1375	216	6	g	g	PROPN
dti-1375	216	7	--doxorubicin	--doxorubicin	PROPN
dti-1375	216	8	d	d	PROPN
dti-1375	216	9	ox	ox	NOUN
dti-1375	216	10	0	0	NUM
dti-1375	216	11	control	control	NOUN
dti-1375	216	12	2	2	NUM
dti-1375	216	13	d	d	SYM
dti-1375	216	14	4	4	NUM
dti-1375	216	15	d	d	NOUN
dti-1375	216	16	ssc	ssc	X
dti-1375	216	17	f	f	NOUN
dti-1375	216	18	l	l	NOUN
dti-1375	216	19	1	1	NUM
dti-1375	216	20	90	90	NUM
dti-1375	216	21	°	°	NOUN
dti-1375	217	1	lig	lig	PROPN
dti-1375	217	2	h	h	PROPN
dti-1375	217	3	t	t	PROPN
dti-1375	217	4	sc	sc	PROPN
dti-1375	217	5	at	at	ADP
dti-1375	217	6	te	te	ADP
dti-1375	217	7	r	r	NOUN
dti-1375	217	8	6	6	NUM
dti-1375	217	9	d	d	SYM
dti-1375	217	10	50	50	NUM
dti-1375	217	11	100	100	NUM
dti-1375	217	12	200	200	NUM
dti-1375	217	13	300	300	NUM
dti-1375	217	14	350	350	NUM
dti-1375	217	15	250	250	NUM
dti-1375	217	16	150	150	NUM
dti-1375	217	17	0	0	NUM
dti-1375	217	18	control	control	NOUN
dti-1375	217	19	2	2	NUM
dti-1375	217	20	d	d	SYM
dti-1375	217	21	4	4	NUM
dti-1375	218	1	d	d	NOUN
dti-1375	218	2	fsc	fsc	PROPN
dti-1375	218	3	f	f	PROPN
dti-1375	218	4	l	l	PROPN
dti-1375	218	5	1	1	NUM
dti-1375	218	6	6	6	NUM
dti-1375	218	7	d	d	SYM
dti-1375	218	8	50	50	NUM
dti-1375	218	9	100	100	NUM
dti-1375	218	10	200	200	NUM
dti-1375	218	11	300	300	NUM
dti-1375	218	12	350	350	NUM
dti-1375	218	13	250	250	NUM
dti-1375	218	14	150	150	NUM
dti-1375	218	15	a	a	DET
dti-1375	218	16	c	c	NOUN
dti-1375	218	17	b	b	PROPN
dti-1375	218	18	d	d	X
dti-1375	218	19	e	e	X
dti-1375	218	20	f	f	PROPN
dti-1375	218	21	figure	figure	VERB
dti-1375	218	22	3	3	NUM
dti-1375	218	23	.	.	PUNCT
dti-1375	219	1	molecular	molecular	ADJ
dti-1375	219	2	characterization	characterization	NOUN
dti-1375	219	3	of	of	ADP
dti-1375	219	4	17aag	17aag	ADJ
dti-1375	219	5	pre	pre	ADJ
dti-1375	219	6	-	-	ADJ
dti-1375	219	7	treatment	treatment	NOUN
dti-1375	219	8	accelerated	accelerate	VERB
dti-1375	219	9	cellular	cellular	ADJ
dti-1375	219	10	senescence	senescence	NOUN
dti-1375	219	11	.	.	PUNCT
dti-1375	220	1	(	(	PUNCT
dti-1375	220	2	a	a	X
dti-1375	220	3	)	)	PUNCT
dti-1375	220	4	laser	laser	NOUN
dti-1375	220	5	scanning	scan	VERB
dti-1375	220	6	confocal	confocal	ADJ
dti-1375	220	7	imaging	imaging	NOUN
dti-1375	220	8	microscope	microscope	NOUN
dti-1375	220	9	(	(	PUNCT
dti-1375	220	10	leica	leica	PROPN
dti-1375	220	11	tcs	tcs	PROPN
dti-1375	220	12	sp5	sp5	PROPN
dti-1375	220	13	)	)	PUNCT
dti-1375	220	14	analysis	analysis	NOUN
dti-1375	220	15	of	of	ADP
dti-1375	220	16	cells	cell	NOUN
dti-1375	220	17	stained	stain	VERB
dti-1375	220	18	with	with	ADP
dti-1375	220	19	oregon	oregon	PROPN
dti-1375	220	20	green	green	PROPN
dti-1375	220	21	phalloidin	phalloidin	PROPN
dti-1375	220	22	(	(	PUNCT
dti-1375	220	23	green	green	ADJ
dti-1375	220	24	)	)	PUNCT
dti-1375	220	25	for	for	ADP
dti-1375	220	26	actin	actin	NOUN
dti-1375	220	27	,	,	PUNCT
dti-1375	220	28	and	and	CCONJ
dti-1375	220	29	cmx	cmx	NOUN
dti-1375	220	30	-	-	ADJ
dti-1375	220	31	ros	ros	PROPN
dti-1375	220	32	(	(	PUNCT
dti-1375	220	33	red	red	PROPN
dti-1375	220	34	)	)	PUNCT
dti-1375	220	35	for	for	ADP
dti-1375	220	36	mitochondria	mitochondria	NOUN
dti-1375	220	37	.	.	PUNCT
dti-1375	221	1	the	the	DET
dti-1375	221	2	nucleus	nucleus	NOUN
dti-1375	221	3	was	be	AUX
dti-1375	221	4	stained	stain	VERB
dti-1375	221	5	with	with	ADP
dti-1375	221	6	4′	4′	NUM
dti-1375	221	7	,	,	PUNCT
dti-1375	221	8	6	6	NUM
dti-1375	221	9	-	-	PUNCT
dti-1375	221	10	diamidino-2	diamidino-2	NOUN
dti-1375	221	11	-	-	PUNCT
dti-1375	221	12	phenylindole	phenylindole	NOUN
dti-1375	221	13	(	(	PUNCT
dti-1375	221	14	dapi	dapi	ADJ
dti-1375	221	15	;	;	PUNCT
dti-1375	221	16	blue	blue	ADJ
dti-1375	221	17	)	)	PUNCT
dti-1375	221	18	.	.	PUNCT
dti-1375	222	1	(	(	PUNCT
dti-1375	222	2	b	b	X
dti-1375	222	3	)	)	PUNCT
dti-1375	222	4	90	90	NUM
dti-1375	222	5	°	°	NOUN
dti-1375	222	6	light	light	NOUN
dti-1375	222	7	scatter	scatter	NOUN
dti-1375	222	8	analysis	analysis	NOUN
dti-1375	222	9	by	by	ADP
dti-1375	222	10	facs	fac	NOUN
dti-1375	222	11	.	.	PUNCT
dti-1375	223	1	fl1	fl1	ADV
dti-1375	223	2	vs.	vs.	X
dti-1375	223	3	ssc	ssc	NOUN
dti-1375	223	4	indicates	indicate	VERB
dti-1375	223	5	granularity	granularity	NOUN
dti-1375	223	6	in	in	ADP
dti-1375	223	7	the	the	DET
dti-1375	223	8	cells	cell	NOUN
dti-1375	223	9	and	and	CCONJ
dti-1375	223	10	fl1	fl1	ADV
dti-1375	223	11	vs.	vs.	ADP
dti-1375	223	12	fsc	fsc	PROPN
dti-1375	223	13	indicates	indicate	VERB
dti-1375	223	14	particle	particle	NOUN
dti-1375	223	15	size	size	NOUN
dti-1375	223	16	inside	inside	ADP
dti-1375	223	17	the	the	DET
dti-1375	223	18	cells	cell	NOUN
dti-1375	223	19	.	.	PUNCT
dti-1375	224	1	(	(	PUNCT
dti-1375	224	2	c	c	X
dti-1375	224	3	)	)	PUNCT
dti-1375	224	4	real	real	ADJ
dti-1375	224	5	-	-	PUNCT
dti-1375	224	6	time	time	NOUN
dti-1375	224	7	pcr	pcr	ADJ
dti-1375	224	8	analysis	analysis	NOUN
dti-1375	224	9	of	of	ADP
dti-1375	224	10	telomerase	telomerase	NOUN
dti-1375	224	11	activity	activity	NOUN
dti-1375	224	12	.	.	PUNCT
dti-1375	225	1	real	real	ADJ
dti-1375	225	2	time	time	NOUN
dti-1375	225	3	threshold	threshold	NOUN
dti-1375	225	4	(	(	PUNCT
dti-1375	225	5	ct	ct	NOUN
dti-1375	225	6	)	)	PUNCT
dti-1375	225	7	was	be	AUX
dti-1375	225	8	calculated	calculate	VERB
dti-1375	225	9	from	from	ADP
dti-1375	225	10	the	the	DET
dti-1375	225	11	kit	kit	NOUN
dti-1375	225	12	standards	standard	NOUN
dti-1375	225	13	and	and	CCONJ
dti-1375	225	14	represented	represent	VERB
dti-1375	225	15	in	in	ADP
dti-1375	225	16	bar	bar	NOUN
dti-1375	225	17	diagram	diagram	NOUN
dti-1375	225	18	.	.	PUNCT
dti-1375	226	1	(	(	PUNCT
dti-1375	226	2	d	d	X
dti-1375	226	3	)	)	PUNCT
dti-1375	226	4	cyto	cyto	NOUN
dti-1375	226	5	-	-	PUNCT
dti-1375	226	6	immunofluorescence	immunofluorescence	NOUN
dti-1375	226	7	analysis	analysis	NOUN
dti-1375	226	8	of	of	ADP
dti-1375	226	9	γh2ax	γh2ax	PROPN
dti-1375	226	10	for	for	ADP
dti-1375	226	11	17aag	17aag	ADJ
dti-1375	226	12	pretreated	pretreate	VERB
dti-1375	226	13	cells	cell	NOUN
dti-1375	226	14	for	for	ADP
dti-1375	226	15	2	2	NUM
dti-1375	226	16	,	,	PUNCT
dti-1375	226	17	4	4	NUM
dti-1375	226	18	and	and	CCONJ
dti-1375	226	19	6	6	NUM
dti-1375	226	20	-	-	PUNCT
dti-1375	226	21	days	day	NOUN
dti-1375	226	22	.	.	PUNCT
dti-1375	227	1	a	a	DET
dti-1375	227	2	6	6	NUM
dti-1375	227	3	-	-	PUNCT
dti-1375	227	4	day	day	NOUN
dti-1375	227	5	doxorubicin	doxorubicin	PROPN
dti-1375	227	6	treated	treat	VERB
dti-1375	227	7	cells	cell	NOUN
dti-1375	227	8	were	be	AUX
dti-1375	227	9	also	also	ADV
dti-1375	227	10	presented	present	VERB
dti-1375	227	11	for	for	ADP
dti-1375	227	12	comparison	comparison	NOUN
dti-1375	227	13	.	.	PUNCT
dti-1375	228	1	the	the	DET
dti-1375	228	2	secondary	secondary	ADJ
dti-1375	228	3	antibodies	antibody	NOUN
dti-1375	228	4	were	be	AUX
dti-1375	228	5	conjugated	conjugate	VERB
dti-1375	228	6	to	to	ADP
dti-1375	228	7	fluorescein	fluorescein	ADJ
dti-1375	228	8	isothiocyanate	isothiocyanate	NOUN
dti-1375	228	9	(	(	PUNCT
dti-1375	228	10	fitc	fitc	PROPN
dti-1375	228	11	)	)	PUNCT
dti-1375	228	12	,	,	PUNCT
dti-1375	228	13	therefore	therefore	ADV
dti-1375	228	14	green	green	ADJ
dti-1375	228	15	color	color	NOUN
dti-1375	228	16	represents	represent	VERB
dti-1375	228	17	γh2ax	γh2ax	PROPN
dti-1375	228	18	.	.	PUNCT
dti-1375	229	1	dapi	dapi	PROPN
dti-1375	229	2	was	be	AUX
dti-1375	229	3	used	use	VERB
dti-1375	229	4	for	for	ADP
dti-1375	229	5	nucleus	nucleus	ADJ
dti-1375	229	6	staining	staining	NOUN
dti-1375	229	7	.	.	PUNCT
dti-1375	230	1	(	(	PUNCT
dti-1375	230	2	e	e	X
dti-1375	230	3	)	)	PUNCT
dti-1375	230	4	cyto	cyto	NOUN
dti-1375	230	5	-	-	PUNCT
dti-1375	230	6	immunofluorescence	immunofluorescence	NOUN
dti-1375	230	7	analysis	analysis	NOUN
dti-1375	230	8	for	for	ADP
dti-1375	230	9	h3k4me3	h3k4me3	NOUN
dti-1375	230	10	at	at	ADP
dti-1375	230	11	2	2	NUM
dti-1375	230	12	,	,	PUNCT
dti-1375	230	13	4	4	NUM
dti-1375	230	14	and	and	CCONJ
dti-1375	230	15	6	6	NUM
dti-1375	230	16	-	-	PUNCT
dti-1375	230	17	day	day	NOUN
dti-1375	230	18	time	time	NOUN
dti-1375	230	19	intervals	interval	NOUN
dti-1375	230	20	.	.	PUNCT
dti-1375	231	1	secondary	secondary	ADJ
dti-1375	231	2	antibodies	antibody	NOUN
dti-1375	231	3	were	be	AUX
dti-1375	231	4	conjugated	conjugate	VERB
dti-1375	231	5	to	to	PART
dti-1375	231	6	fitc	fitc	VERB
dti-1375	231	7	,	,	PUNCT
dti-1375	231	8	hence	hence	ADV
dti-1375	231	9	green	green	ADJ
dti-1375	231	10	color	color	NOUN
dti-1375	231	11	represents	represent	VERB
dti-1375	231	12	h3k4me3	h3k4me3	PROPN
dti-1375	231	13	.	.	PUNCT
dti-1375	232	1	dapi	dapi	PROPN
dti-1375	232	2	was	be	AUX
dti-1375	232	3	used	use	VERB
dti-1375	232	4	for	for	ADP
dti-1375	232	5	nucleus	nucleus	ADJ
dti-1375	232	6	staining	staining	NOUN
dti-1375	232	7	.	.	PUNCT
dti-1375	233	1	(	(	PUNCT
dti-1375	233	2	f	f	X
dti-1375	233	3	)	)	PUNCT
dti-1375	233	4	cyto	cyto	NOUN
dti-1375	233	5	-	-	PUNCT
dti-1375	233	6	immunofluorescence	immunofluorescence	NOUN
dti-1375	233	7	analysis	analysis	NOUN
dti-1375	233	8	of	of	ADP
dti-1375	233	9	p16ink-4a	p16ink-4a	NOUN
dti-1375	233	10	at	at	ADP
dti-1375	233	11	2	2	NUM
dti-1375	233	12	,	,	PUNCT
dti-1375	233	13	4	4	NUM
dti-1375	233	14	and	and	CCONJ
dti-1375	233	15	6	6	NUM
dti-1375	233	16	-	-	PUNCT
dti-1375	233	17	day	day	NOUN
dti-1375	233	18	time	time	NOUN
dti-1375	233	19	intervals	interval	NOUN
dti-1375	233	20	.	.	PUNCT
dti-1375	234	1	the	the	DET
dti-1375	234	2	secondary	secondary	ADJ
dti-1375	234	3	antibodies	antibody	NOUN
dti-1375	234	4	were	be	AUX
dti-1375	234	5	conjugated	conjugate	VERB
dti-1375	234	6	to	to	ADP
dti-1375	234	7	fitc	fitc	PROPN
dti-1375	234	8	.	.	PUNCT
dti-1375	235	1	nucleus	nucleus	PROPN
dti-1375	235	2	was	be	AUX
dti-1375	235	3	stained	stain	VERB
dti-1375	235	4	with	with	ADP
dti-1375	235	5	dapi	dapi	PROPN
dti-1375	235	6	.	.	PUNCT
dti-1375	236	1	for	for	ADP
dti-1375	236	2	all	all	DET
dti-1375	236	3	microscopy	microscopy	NOUN
dti-1375	236	4	images	image	NOUN
dti-1375	236	5	,	,	PUNCT
dti-1375	236	6	the	the	DET
dti-1375	236	7	scale	scale	NOUN
dti-1375	236	8	bar	bar	NOUN
dti-1375	236	9	represents	represent	VERB
dti-1375	236	10	25	25	NUM
dti-1375	236	11	µm	µm	NOUN
dti-1375	236	12	at	at	ADP
dti-1375	236	13	100x	100x	NUM
dti-1375	236	14	magnification	magnification	NOUN
dti-1375	236	15	,	,	PUNCT
dti-1375	236	16	the	the	DET
dti-1375	236	17	z	z	NOUN
dti-1375	236	18	-	-	PUNCT
dti-1375	236	19	section	section	NOUN
dti-1375	236	20	of	of	ADP
dti-1375	236	21	each	each	DET
dti-1375	236	22	image	image	NOUN
dti-1375	236	23	was	be	AUX
dti-1375	236	24	taken	take	VERB
dti-1375	236	25	at	at	ADP
dti-1375	236	26	0.35	0.35	NUM
dti-1375	236	27	µm	µm	ADP
dti-1375	236	28	intervals	interval	NOUN
dti-1375	236	29	,	,	PUNCT
dti-1375	236	30	and	and	CCONJ
dti-1375	236	31	images	image	NOUN
dti-1375	236	32	represented	represent	VERB
dti-1375	236	33	are	be	AUX
dti-1375	236	34	the	the	DET
dti-1375	236	35	merge	merge	NOUN
dti-1375	236	36	of	of	ADP
dti-1375	236	37	best	good	ADJ
dti-1375	236	38	z	z	NOUN
dti-1375	236	39	-	-	PUNCT
dti-1375	236	40	sections	section	NOUN
dti-1375	236	41	.	.	PUNCT
dti-1375	237	1	http://www.la-press.com	http://www.la-press.com	X
dti-1375	238	1	sarangi	sarangi	PROPN
dti-1375	238	2	et	et	PROPN
dti-1375	238	3	al	al	PROPN
dti-1375	238	4	28	28	NUM
dti-1375	238	5	drug	drug	NOUN
dti-1375	238	6	target	target	NOUN
dti-1375	238	7	insights	insight	NOUN
dti-1375	238	8	2012:6	2012:6	NUM
dti-1375	238	9	0	0	NUM
dti-1375	238	10	control	control	NOUN
dti-1375	238	11	brefelvin	brefelvin	NOUN
dti-1375	238	12	a	a	PRON
dti-1375	238	13	2	2	NUM
dti-1375	238	14	d	d	SYM
dti-1375	238	15	4	4	NUM
dti-1375	238	16	d	d	NOUN
dti-1375	238	17	treatment	treatment	NOUN
dti-1375	238	18	(	(	PUNCT
dti-1375	238	19	days	day	NOUN
dti-1375	238	20	)	)	PUNCT
dti-1375	238	21	6	6	NUM
dti-1375	238	22	d	d	NOUN
dti-1375	238	23	100	100	NUM
dti-1375	238	24	200	200	NUM
dti-1375	238	25	f	f	NOUN
dti-1375	238	26	lu	lu	NOUN
dti-1375	238	27	o	o	X
dti-1375	238	28	re	re	X
dti-1375	238	29	sc	sc	PROPN
dti-1375	238	30	en	en	PROPN
dti-1375	238	31	ce	ce	PROPN
dti-1375	238	32	in	in	ADP
dti-1375	238	33	te	te	PROPN
dti-1375	238	34	n	n	CCONJ
dti-1375	238	35	si	si	INTJ
dti-1375	239	1	ty	ty	INTJ
dti-1375	239	2	(	(	PUNCT
dti-1375	239	3	a	a	DET
dti-1375	239	4	rb	rb	NOUN
dti-1375	239	5	it	it	PRON
dti-1375	239	6	ra	ra	INTJ
dti-1375	239	7	ry	ry	INTJ
dti-1375	239	8	u	u	PROPN
dti-1375	239	9	n	n	PROPN
dti-1375	239	10	it	it	PRON
dti-1375	239	11	s	s	VERB
dti-1375	239	12	)	)	PUNCT
dti-1375	239	13	300	300	NUM
dti-1375	239	14	400	400	NUM
dti-1375	239	15	500	500	NUM
dti-1375	239	16	0	0	NUM
dti-1375	239	17	control	control	NOUN
dti-1375	239	18	h2o2	h2o2	NOUN
dti-1375	239	19	2	2	NUM
dti-1375	239	20	d	d	SYM
dti-1375	239	21	4	4	NUM
dti-1375	239	22	d	d	NOUN
dti-1375	239	23	treatment	treatment	NOUN
dti-1375	239	24	(	(	PUNCT
dti-1375	239	25	days	day	NOUN
dti-1375	239	26	)	)	PUNCT
dti-1375	239	27	6	6	NUM
dti-1375	239	28	d	d	NOUN
dti-1375	239	29	20	20	NUM
dti-1375	239	30	40	40	NUM
dti-1375	239	31	p	p	NOUN
dti-1375	239	32	er	er	INTJ
dti-1375	239	33	ce	ce	PROPN
dti-1375	239	34	n	n	ADP
dti-1375	239	35	t	t	PROPN
dti-1375	239	36	r	r	NOUN
dti-1375	239	37	o	o	X
dti-1375	239	38	s	s	AUX
dti-1375	239	39	le	le	X
dti-1375	239	40	ve	ve	AUX
dti-1375	239	41	ls	l	VERB
dti-1375	239	42	60	60	NUM
dti-1375	239	43	80	80	NUM
dti-1375	239	44	100	100	NUM
dti-1375	239	45	0	0	NUM
dti-1375	239	46	control	control	NOUN
dti-1375	239	47	2	2	NUM
dti-1375	239	48	d	d	SYM
dti-1375	239	49	4	4	NUM
dti-1375	239	50	d	d	NOUN
dti-1375	239	51	treatment	treatment	NOUN
dti-1375	239	52	(	(	PUNCT
dti-1375	239	53	days	day	NOUN
dti-1375	239	54	)	)	PUNCT
dti-1375	239	55	6	6	NUM
dti-1375	239	56	d	d	SYM
dti-1375	239	57	20	20	NUM
dti-1375	239	58	40	40	NUM
dti-1375	239	59	jc	jc	PROPN
dti-1375	239	60	-1	-1	PROPN
dti-1375	239	61	fl	fl	NUM
dti-1375	239	62	u	u	PROPN
dti-1375	239	63	o	o	X
dti-1375	239	64	re	re	X
dti-1375	239	65	sc	sc	PROPN
dti-1375	239	66	en	en	PROPN
dti-1375	239	67	ce	ce	PROPN
dti-1375	239	68	re	re	PROPN
dti-1375	239	69	d	d	PROPN
dti-1375	239	70	/g	/g	PUNCT
dti-1375	239	71	re	re	VERB
dti-1375	239	72	en	en	ADP
dti-1375	239	73	r	r	NOUN
dti-1375	239	74	at	at	ADP
dti-1375	239	75	io	io	PROPN
dti-1375	239	76	60	60	NUM
dti-1375	239	77	80	80	NUM
dti-1375	239	78	100	100	NUM
dti-1375	239	79	s	s	NOUN
dti-1375	239	80	o	o	X
dti-1375	239	81	d	d	X
dti-1375	239	82	1/	1/	NUM
dti-1375	239	83	g	g	PROPN
dti-1375	239	84	a	a	DET
dti-1375	239	85	p	p	X
dti-1375	239	86	d	d	X
dti-1375	239	87	h	h	NOUN
dti-1375	239	88	m	m	NOUN
dti-1375	239	89	r	r	NOUN
dti-1375	239	90	n	n	NOUN
dti-1375	239	91	a	a	DET
dti-1375	239	92	r	r	NOUN
dti-1375	239	93	at	at	ADP
dti-1375	239	94	io	io	PROPN
dti-1375	239	95	0	0	PROPN
dti-1375	239	96	control	control	PROPN
dti-1375	239	97	2	2	NUM
dti-1375	239	98	d2	d2	PROPN
dti-1375	239	99	d	d	ADP
dti-1375	239	100	4	4	NUM
dti-1375	239	101	d4	d4	PROPN
dti-1375	239	102	d	d	PROPN
dti-1375	239	103	6	6	NUM
dti-1375	239	104	d6	d6	NOUN
dti-1375	239	105	d	d	X
dti-1375	239	106	control	control	NOUN
dti-1375	239	107	2	2	NUM
dti-1375	239	108	d2	d2	PROPN
dti-1375	239	109	d	d	ADP
dti-1375	239	110	4	4	NUM
dti-1375	239	111	d4	d4	PROPN
dti-1375	239	112	d	d	PROPN
dti-1375	239	113	6	6	NUM
dti-1375	239	114	d6	d6	NOUN
dti-1375	239	115	d	d	NOUN
dti-1375	239	116	control	control	NOUN
dti-1375	239	117	2	2	NUM
dti-1375	239	118	d	d	SYM
dti-1375	239	119	4	4	NUM
dti-1375	239	120	d	d	SYM
dti-1375	239	121	6	6	NUM
dti-1375	239	122	d	d	SYM
dti-1375	239	123	1.0	1.0	NUM
dti-1375	239	124	0.5	0.5	NUM
dti-1375	239	125	1.5	1.5	NUM
dti-1375	239	126	c	c	NOUN
dti-1375	239	127	at	at	ADP
dti-1375	239	128	al	al	PROPN
dti-1375	239	129	as	as	ADP
dti-1375	239	130	e/	e/	ADV
dti-1375	239	131	g	g	PROPN
dti-1375	239	132	a	a	PRON
dti-1375	240	1	p	p	X
dti-1375	240	2	d	d	X
dti-1375	240	3	h	h	NOUN
dti-1375	240	4	m	m	NOUN
dti-1375	240	5	r	r	NOUN
dti-1375	240	6	n	n	NOUN
dti-1375	240	7	a	a	DET
dti-1375	240	8	r	r	NOUN
dti-1375	240	9	at	at	ADP
dti-1375	240	10	io	io	PROPN
dti-1375	240	11	0	0	PROPN
dti-1375	240	12	control	control	PROPN
dti-1375	240	13	2	2	NUM
dti-1375	240	14	d2	d2	PROPN
dti-1375	240	15	d	d	ADP
dti-1375	240	16	4	4	NUM
dti-1375	240	17	d4	d4	PROPN
dti-1375	240	18	d	d	PROPN
dti-1375	240	19	6	6	NUM
dti-1375	240	20	d6	d6	NOUN
dti-1375	240	21	d	d	NOUN
dti-1375	240	22	1.0	1.0	NUM
dti-1375	240	23	0.5	0.5	NUM
dti-1375	240	24	1.5	1.5	NUM
dti-1375	240	25	s	s	NOUN
dti-1375	240	26	o	o	X
dti-1375	240	27	d	d	X
dti-1375	240	28	2/	2/	NUM
dti-1375	240	29	g	g	ADP
dti-1375	240	30	a	a	DET
dti-1375	240	31	p	p	X
dti-1375	240	32	d	d	X
dti-1375	240	33	h	h	NOUN
dti-1375	240	34	m	m	NOUN
dti-1375	240	35	r	r	NOUN
dti-1375	240	36	n	n	NOUN
dti-1375	240	37	a	a	DET
dti-1375	240	38	r	r	NOUN
dti-1375	240	39	at	at	ADP
dti-1375	240	40	io	io	PROPN
dti-1375	240	41	0	0	PROPN
dti-1375	240	42	control	control	PROPN
dti-1375	240	43	2	2	NUM
dti-1375	240	44	d2	d2	PROPN
dti-1375	240	45	d	d	ADP
dti-1375	240	46	4	4	NUM
dti-1375	240	47	d4	d4	PROPN
dti-1375	240	48	d	d	PROPN
dti-1375	240	49	6	6	NUM
dti-1375	240	50	d6	d6	NOUN
dti-1375	240	51	d	d	ADP
dti-1375	240	52	2.0	2.0	NUM
dti-1375	240	53	3.0	3.0	NUM
dti-1375	240	54	1.0	1.0	NUM
dti-1375	240	55	4.0	4.0	NUM
dti-1375	240	56	sod1	sod1	ADJ
dti-1375	240	57	sod2	sod2	NOUN
dti-1375	240	58	catalase	catalase	NOUN
dti-1375	240	59	gapdh	gapdh	NOUN
dti-1375	240	60	doxo--17aag	doxo--17aag	ADJ
dti-1375	240	61	17aag	17aag	NOUN
dti-1375	240	62	--	--	PUNCT
dti-1375	240	63	doxo	doxo	PROPN
dti-1375	240	64	fitc	fitc	NOUN
dti-1375	240	65	dsred	dsre	VERB
dti-1375	240	66	fluorescence	fluorescence	NOUN
dti-1375	240	67	filter	filter	NOUN
dti-1375	240	68	merge	merge	VERB
dti-1375	240	69	a	a	PRON
dti-1375	240	70	d	d	X
dti-1375	240	71	d1	d1	PROPN
dti-1375	240	72	b	b	PROPN
dti-1375	240	73	c	c	NOUN
dti-1375	240	74	e	e	NOUN
dti-1375	240	75	figure	figure	NOUN
dti-1375	240	76	4	4	NUM
dti-1375	240	77	.	.	PUNCT
dti-1375	240	78	effects	effect	NOUN
dti-1375	240	79	of	of	ADP
dti-1375	240	80	17aag	17aag	ADJ
dti-1375	240	81	pre	pre	NOUN
dti-1375	240	82	-	-	NOUN
dti-1375	240	83	treatment	treatment	NOUN
dti-1375	240	84	on	on	ADP
dti-1375	240	85	cellular	cellular	ADJ
dti-1375	240	86	redox	redox	ADJ
dti-1375	240	87	status	status	NOUN
dti-1375	240	88	.	.	PUNCT
dti-1375	241	1	(	(	PUNCT
dti-1375	241	2	a	a	X
dti-1375	241	3	)	)	PUNCT
dti-1375	242	1	[	[	X
dti-1375	242	2	(	(	PUNCT
dti-1375	242	3	ca2+)i	ca2+)i	NOUN
dti-1375	242	4	]	]	PUNCT
dti-1375	242	5	was	be	AUX
dti-1375	242	6	measured	measure	VERB
dti-1375	242	7	by	by	ADP
dti-1375	242	8	staining	stain	VERB
dti-1375	242	9	cells	cell	NOUN
dti-1375	242	10	with	with	ADP
dti-1375	242	11	fluo3	fluo3	NOUN
dti-1375	242	12	-	-	PUNCT
dti-1375	242	13	am	am	NOUN
dti-1375	242	14	and	and	CCONJ
dti-1375	242	15	analyzed	analyze	VERB
dti-1375	242	16	by	by	ADP
dti-1375	242	17	facs	fac	NOUN
dti-1375	242	18	.	.	PUNCT
dti-1375	243	1	brefeldin	brefeldin	VERB
dti-1375	243	2	a	a	PRON
dti-1375	243	3	was	be	AUX
dti-1375	243	4	used	use	VERB
dti-1375	243	5	as	as	ADP
dti-1375	243	6	positive	positive	ADJ
dti-1375	243	7	control	control	NOUN
dti-1375	243	8	to	to	PART
dti-1375	243	9	induce	induce	VERB
dti-1375	243	10	ca2	ca2	PROPN
dti-1375	243	11	+	+	NOUN
dti-1375	243	12	release	release	NOUN
dti-1375	243	13	into	into	ADP
dti-1375	243	14	the	the	DET
dti-1375	243	15	intracellular	intracellular	ADJ
dti-1375	243	16	milieu	milieu	NOUN
dti-1375	243	17	.	.	PUNCT
dti-1375	244	1	(	(	PUNCT
dti-1375	244	2	b	b	X
dti-1375	244	3	)	)	PUNCT
dti-1375	245	1	[	[	X
dti-1375	245	2	(	(	PUNCT
dti-1375	245	3	ros)i	ros)i	NOUN
dti-1375	245	4	]	]	PUNCT
dti-1375	245	5	was	be	AUX
dti-1375	245	6	measured	measure	VERB
dti-1375	245	7	by	by	ADP
dti-1375	245	8	incubating	incubate	VERB
dti-1375	245	9	cells	cell	NOUN
dti-1375	245	10	with	with	ADP
dti-1375	245	11	cm	cm	NOUN
dti-1375	245	12	-	-	PUNCT
dti-1375	245	13	h2dcfda	h2dcfda	PROPN
dti-1375	245	14	and	and	CCONJ
dti-1375	245	15	analyzing	analyze	VERB
dti-1375	245	16	the	the	DET
dti-1375	245	17	green	green	ADJ
dti-1375	245	18	fluorescence	fluorescence	NOUN
dti-1375	245	19	by	by	ADP
dti-1375	245	20	facs	fac	NOUN
dti-1375	245	21	.	.	PUNCT
dti-1375	246	1	hydrogen	hydrogen	NOUN
dti-1375	246	2	peroxide	peroxide	NOUN
dti-1375	246	3	(	(	PUNCT
dti-1375	246	4	h2o2	h2o2	NOUN
dti-1375	246	5	)	)	PUNCT
dti-1375	246	6	was	be	AUX
dti-1375	246	7	used	use	VERB
dti-1375	246	8	as	as	ADP
dti-1375	246	9	a	a	DET
dti-1375	246	10	positive	positive	ADJ
dti-1375	246	11	control	control	NOUN
dti-1375	246	12	to	to	PART
dti-1375	246	13	induce	induce	VERB
dti-1375	246	14	[	[	X
dti-1375	246	15	(	(	PUNCT
dti-1375	246	16	ros)i	ros)i	NOUN
dti-1375	246	17	]	]	PUNCT
dti-1375	246	18	levels	level	NOUN
dti-1375	246	19	.	.	PUNCT
dti-1375	247	1	(	(	PUNCT
dti-1375	247	2	c	c	X
dti-1375	247	3	)	)	PUNCT
dti-1375	247	4	a	a	DET
dti-1375	247	5	change	change	NOUN
dti-1375	247	6	in	in	ADP
dti-1375	247	7	mitochondrial	mitochondrial	ADJ
dti-1375	247	8	membrane	membrane	NOUN
dti-1375	247	9	potential	potential	NOUN
dti-1375	247	10	(	(	PUNCT
dti-1375	247	11	∆ψm	∆ψm	PROPN
dti-1375	247	12	)	)	PUNCT
dti-1375	247	13	was	be	AUX
dti-1375	247	14	measured	measure	VERB
dti-1375	247	15	by	by	ADP
dti-1375	247	16	staining	stain	VERB
dti-1375	247	17	cells	cell	NOUN
dti-1375	247	18	with	with	ADP
dti-1375	247	19	jc-1	jc-1	NOUN
dti-1375	247	20	fluorophore	fluorophore	NOUN
dti-1375	247	21	and	and	CCONJ
dti-1375	247	22	analyzing	analyze	VERB
dti-1375	247	23	in	in	ADP
dti-1375	247	24	facs	fac	NOUN
dti-1375	247	25	.	.	PUNCT
dti-1375	248	1	an	an	DET
dti-1375	248	2	increase	increase	NOUN
dti-1375	248	3	in	in	ADP
dti-1375	248	4	red	red	ADJ
dti-1375	248	5	to	to	ADP
dti-1375	248	6	green	green	ADJ
dti-1375	248	7	fluorescence	fluorescence	NOUN
dti-1375	248	8	ratio	ratio	NOUN
dti-1375	248	9	was	be	AUX
dti-1375	248	10	plotted	plot	VERB
dti-1375	248	11	in	in	ADP
dti-1375	248	12	the	the	DET
dti-1375	248	13	bar	bar	NOUN
dti-1375	248	14	diagram	diagram	NOUN
dti-1375	248	15	.	.	PUNCT
dti-1375	249	1	(	(	PUNCT
dti-1375	249	2	d	d	X
dti-1375	249	3	)	)	PUNCT
dti-1375	249	4	rt	rt	ADJ
dti-1375	249	5	-	-	PUNCT
dti-1375	249	6	pcr	pcr	NOUN
dti-1375	249	7	analyses	analysis	NOUN
dti-1375	249	8	with	with	ADP
dti-1375	249	9	gene	gene	NOUN
dti-1375	249	10	specific	specific	ADJ
dti-1375	249	11	primers	primer	NOUN
dti-1375	249	12	for	for	ADP
dti-1375	249	13	sod1	sod1	NOUN
dti-1375	249	14	,	,	PUNCT
dti-1375	249	15	sod2	sod2	NOUN
dti-1375	249	16	and	and	CCONJ
dti-1375	249	17	catalase	catalase	NOUN
dti-1375	249	18	.	.	PUNCT
dti-1375	250	1	the	the	DET
dti-1375	250	2	gapdh	gapdh	NOUN
dti-1375	250	3	amplification	amplification	NOUN
dti-1375	250	4	was	be	AUX
dti-1375	250	5	used	use	VERB
dti-1375	250	6	as	as	ADP
dti-1375	250	7	input	input	NOUN
dti-1375	250	8	.	.	PUNCT
dti-1375	251	1	(	(	PUNCT
dti-1375	251	2	d1	d1	NOUN
dti-1375	251	3	)	)	PUNCT
dti-1375	251	4	the	the	DET
dti-1375	251	5	densitometric	densitometric	ADJ
dti-1375	251	6	values	value	NOUN
dti-1375	251	7	of	of	ADP
dti-1375	251	8	gapdh	gapdh	NOUN
dti-1375	251	9	vs.	vs.	ADP
dti-1375	251	10	individual	individual	ADJ
dti-1375	251	11	gene	gene	NOUN
dti-1375	251	12	expression	expression	NOUN
dti-1375	251	13	ratios	ratio	NOUN
dti-1375	251	14	was	be	AUX
dti-1375	251	15	represented	represent	VERB
dti-1375	251	16	in	in	ADP
dti-1375	251	17	the	the	DET
dti-1375	251	18	bar	bar	NOUN
dti-1375	251	19	diagram	diagram	NOUN
dti-1375	251	20	.	.	PUNCT
dti-1375	252	1	(	(	PUNCT
dti-1375	252	2	e	e	NOUN
dti-1375	252	3	)	)	PUNCT
dti-1375	252	4	staining	stain	VERB
dti-1375	252	5	of	of	ADP
dti-1375	252	6	autophagic	autophagic	ADJ
dti-1375	252	7	vacuoles	vacuole	NOUN
dti-1375	252	8	.	.	PUNCT
dti-1375	253	1	cells	cell	NOUN
dti-1375	253	2	were	be	AUX
dti-1375	253	3	incubated	incubate	VERB
dti-1375	253	4	with	with	ADP
dti-1375	253	5	acridine	acridine	ADJ
dti-1375	253	6	organge	organge	NOUN
dti-1375	253	7	to	to	PART
dti-1375	253	8	stain	stain	VERB
dti-1375	253	9	acidic	acidic	ADJ
dti-1375	253	10	lysosomes	lysosome	NOUN
dti-1375	253	11	characteristic	characteristic	ADJ
dti-1375	253	12	of	of	ADP
dti-1375	253	13	autophagy	autophagy	NOUN
dti-1375	253	14	.	.	PUNCT
dti-1375	254	1	green	green	PROPN
dti-1375	254	2	indicates	indicate	VERB
dti-1375	254	3	nuclear	nuclear	ADJ
dti-1375	254	4	staining	staining	NOUN
dti-1375	254	5	and	and	CCONJ
dti-1375	254	6	red	red	ADJ
dti-1375	254	7	indicates	indicate	VERB
dti-1375	254	8	acidic	acidic	ADJ
dti-1375	254	9	lysosomal	lysosomal	ADJ
dti-1375	254	10	staining	staining	NOUN
dti-1375	254	11	.	.	PUNCT
dti-1375	255	1	scale	scale	NOUN
dti-1375	255	2	bar	bar	NOUN
dti-1375	255	3	represents	represent	VERB
dti-1375	255	4	25	25	NUM
dti-1375	255	5	µm	µm	NOUN
dti-1375	255	6	at	at	ADP
dti-1375	255	7	100×	100×	PROPN
dti-1375	255	8	magnification	magnification	NOUN
dti-1375	255	9	in	in	ADP
dti-1375	255	10	a	a	DET
dti-1375	255	11	laser	laser	NOUN
dti-1375	255	12	scanning	scan	VERB
dti-1375	255	13	confocal	confocal	ADJ
dti-1375	255	14	imaging	imaging	NOUN
dti-1375	255	15	microscope	microscope	NOUN
dti-1375	255	16	,	,	PUNCT
dti-1375	255	17	leica	leica	PROPN
dti-1375	255	18	tcs	tcs	PROPN
dti-1375	255	19	sp5	sp5	PROPN
dti-1375	255	20	.	.	PROPN
dti-1375	256	1	versus	versus	ADP
dti-1375	256	2	gapdh	gapdh	NOUN
dti-1375	256	3	ratio	ratio	NOUN
dti-1375	256	4	(	(	PUNCT
dti-1375	256	5	fig	fig	NOUN
dti-1375	256	6	.	.	PUNCT
dti-1375	257	1	4d1	4d1	NUM
dti-1375	257	2	)	)	PUNCT
dti-1375	257	3	.	.	PUNCT
dti-1375	258	1	in	in	ADP
dti-1375	258	2	agreement	agreement	NOUN
dti-1375	258	3	with	with	ADP
dti-1375	258	4	moderate	moderate	ADJ
dti-1375	258	5	increases	increase	NOUN
dti-1375	258	6	in	in	ADP
dti-1375	258	7	oxidative	oxidative	ADJ
dti-1375	258	8	stress	stress	NOUN
dti-1375	258	9	that	that	PRON
dti-1375	258	10	correlated	correlate	VERB
dti-1375	258	11	to	to	ADP
dti-1375	258	12	sensitizing	sensitize	VERB
dti-1375	258	13	effects	effect	NOUN
dti-1375	258	14	of	of	ADP
dti-1375	258	15	cellular	cellular	ADJ
dti-1375	258	16	senescence27	senescence27	NOUN
dti-1375	258	17	but	but	CCONJ
dti-1375	258	18	not	not	PART
dti-1375	258	19	to	to	PART
dti-1375	258	20	apoptosis	apoptosis	VERB
dti-1375	258	21	,	,	PUNCT
dti-1375	258	22	we	we	PRON
dti-1375	258	23	also	also	ADV
dti-1375	258	24	observed	observe	VERB
dti-1375	258	25	a	a	DET
dti-1375	258	26	moderate	moderate	ADJ
dti-1375	258	27	increase	increase	NOUN
dti-1375	258	28	in	in	ADP
dti-1375	258	29	[	[	X
dti-1375	258	30	(	(	PUNCT
dti-1375	258	31	ros)i	ros)i	ADP
dti-1375	258	32	]	]	PUNCT
dti-1375	258	33	.	.	PUNCT
dti-1375	259	1	since	since	SCONJ
dti-1375	259	2	senescent	senescent	ADJ
dti-1375	259	3	cells	cell	NOUN
dti-1375	259	4	are	be	AUX
dti-1375	259	5	usually	usually	ADV
dti-1375	259	6	resistant	resistant	ADJ
dti-1375	259	7	to	to	ADP
dti-1375	259	8	apoptosis	apoptosis	NOUN
dti-1375	259	9	or	or	CCONJ
dti-1375	259	10	necrosis	necrosis	NOUN
dti-1375	259	11	,	,	PUNCT
dti-1375	259	12	removal	removal	NOUN
dti-1375	259	13	of	of	ADP
dti-1375	259	14	damaged	damage	VERB
dti-1375	259	15	cells	cell	NOUN
dti-1375	259	16	could	could	AUX
dti-1375	259	17	occur	occur	VERB
dti-1375	259	18	by	by	ADP
dti-1375	259	19	autophagy	autophagy	NOUN
dti-1375	259	20	(	(	PUNCT
dti-1375	259	21	type	type	NOUN
dti-1375	259	22	ii	ii	NOUN
dti-1375	259	23	programmed	program	VERB
dti-1375	259	24	cell	cell	NOUN
dti-1375	259	25	death	death	NOUN
dti-1375	259	26	)	)	PUNCT
dti-1375	259	27	.	.	PUNCT
dti-1375	260	1	accordingly	accordingly	ADV
dti-1375	260	2	,	,	PUNCT
dti-1375	260	3	senescent	senescent	ADJ
dti-1375	260	4	cells	cell	NOUN
dti-1375	260	5	showed	show	VERB
dti-1375	260	6	enhanced	enhanced	ADJ
dti-1375	260	7	acridine	acridine	PROPN
dti-1375	260	8	orange	orange	PROPN
dti-1375	260	9	staining	staining	PROPN
dti-1375	260	10	,	,	PUNCT
dti-1375	260	11	a	a	DET
dti-1375	260	12	characteristic	characteristic	ADJ
dti-1375	260	13	feature	feature	NOUN
dti-1375	260	14	of	of	ADP
dti-1375	260	15	macroautophagy14	macroautophagy14	NOUN
dti-1375	260	16	(	(	PUNCT
dti-1375	260	17	fig	fig	NOUN
dti-1375	260	18	.	.	PUNCT
dti-1375	261	1	4e	4e	NOUN
dti-1375	261	2	)	)	PUNCT
dti-1375	261	3	.	.	PUNCT
dti-1375	262	1	17aag	17aag	ADJ
dti-1375	262	2	pre	pre	ADJ
dti-1375	262	3	-	-	ADJ
dti-1375	262	4	treatment	treatment	ADJ
dti-1375	262	5	induced	induced	ADJ
dti-1375	262	6	senescence	senescence	NOUN
dti-1375	262	7	is	be	AUX
dti-1375	262	8	irreversible	irreversible	ADJ
dti-1375	262	9	pharmacological	pharmacological	ADJ
dti-1375	262	10	modulator	modulator	NOUN
dti-1375	262	11	curcumin	curcumin	NOUN
dti-1375	262	12	was	be	AUX
dti-1375	262	13	shown	show	VERB
dti-1375	262	14	to	to	PART
dti-1375	262	15	promote	promote	VERB
dti-1375	262	16	proliferation	proliferation	NOUN
dti-1375	262	17	in	in	ADP
dti-1375	262	18	neuroblastoma,6	neuroblastoma,6	PROPN
dti-1375	262	19	therefore	therefore	ADV
dti-1375	262	20	,	,	PUNCT
dti-1375	262	21	we	we	PRON
dti-1375	262	22	examined	examine	VERB
dti-1375	262	23	the	the	DET
dti-1375	262	24	effect	effect	NOUN
dti-1375	262	25	of	of	ADP
dti-1375	262	26	curcumin	curcumin	NOUN
dti-1375	262	27	on	on	ADP
dti-1375	262	28	reversal	reversal	NOUN
dti-1375	262	29	http://www.la-press.com	http://www.la-press.com	X
dti-1375	263	1	hsp90	hsp90	ADJ
dti-1375	263	2	inhibition	inhibition	NOUN
dti-1375	263	3	accelerates	accelerate	VERB
dti-1375	263	4	senescence	senescence	NOUN
dti-1375	263	5	drug	drug	NOUN
dti-1375	263	6	target	target	NOUN
dti-1375	263	7	insights	insight	NOUN
dti-1375	263	8	2012:6	2012:6	NUM
dti-1375	263	9	29	29	NUM
dti-1375	263	10	of	of	ADP
dti-1375	263	11	senescence	senescence	NOUN
dti-1375	263	12	.	.	PUNCT
dti-1375	264	1	although	although	SCONJ
dti-1375	264	2	curcumin	curcumin	NOUN
dti-1375	264	3	(	(	PUNCT
dti-1375	264	4	15	15	NUM
dti-1375	264	5	µm	µm	NOUN
dti-1375	264	6	,	,	PUNCT
dti-1375	264	7	24	24	NUM
dti-1375	264	8	h	h	NOUN
dti-1375	264	9	)	)	PUNCT
dti-1375	264	10	increased	increase	VERB
dti-1375	264	11	the	the	DET
dti-1375	264	12	number	number	NOUN
dti-1375	264	13	of	of	ADP
dti-1375	264	14	sa	sa	PROPN
dti-1375	264	15	-	-	PUNCT
dti-1375	264	16	β	β	NOUN
dti-1375	264	17	-	-	ADJ
dti-1375	264	18	gal	gal	ADJ
dti-1375	264	19	positive	positive	ADJ
dti-1375	264	20	cells	cell	NOUN
dti-1375	264	21	in	in	ADP
dti-1375	264	22	a	a	DET
dti-1375	264	23	day-3	day-3	NOUN
dti-1375	264	24	treatment	treatment	NOUN
dti-1375	264	25	(	(	PUNCT
dti-1375	264	26	.133	.133	NUM
dti-1375	264	27	%	%	NOUN
dti-1375	264	28	,	,	PUNCT
dti-1375	264	29	p	p	X
dti-1375	264	30	,	,	PUNCT
dti-1375	264	31	0.05	0.05	NUM
dti-1375	264	32	)	)	PUNCT
dti-1375	264	33	,	,	PUNCT
dti-1375	264	34	which	which	PRON
dti-1375	264	35	is	be	AUX
dti-1375	264	36	significantly	significantly	ADV
dti-1375	264	37	decreased	decrease	VERB
dti-1375	264	38	by	by	ADP
dti-1375	264	39	day-5	day-5	PUNCT
dti-1375	264	40	treatment	treatment	NOUN
dti-1375	264	41	(	(	PUNCT
dti-1375	264	42	,	,	PUNCT
dti-1375	264	43	37	37	NUM
dti-1375	264	44	%	%	NOUN
dti-1375	264	45	,	,	PUNCT
dti-1375	264	46	p	p	X
dti-1375	264	47	,	,	PUNCT
dti-1375	264	48	0.05	0.05	NUM
dti-1375	264	49	)	)	PUNCT
dti-1375	264	50	.	.	PUNCT
dti-1375	265	1	these	these	DET
dti-1375	265	2	data	datum	NOUN
dti-1375	265	3	(	(	PUNCT
dti-1375	265	4	fig	fig	NOUN
dti-1375	265	5	.	.	PUNCT
dti-1375	265	6	5a	5a	NUM
dti-1375	265	7	)	)	PUNCT
dti-1375	265	8	suggests	suggest	VERB
dti-1375	265	9	that	that	SCONJ
dti-1375	265	10	senescent	senescent	ADJ
dti-1375	265	11	cells	cell	NOUN
dti-1375	265	12	did	do	AUX
dti-1375	265	13	not	not	PART
dti-1375	265	14	respond	respond	VERB
dti-1375	265	15	to	to	ADP
dti-1375	265	16	proliferation	proliferation	NOUN
dti-1375	265	17	stimulus	stimulus	NOUN
dti-1375	265	18	.	.	PUNCT
dti-1375	266	1	we	we	PRON
dti-1375	266	2	further	far	ADV
dti-1375	266	3	examined	examine	VERB
dti-1375	266	4	the	the	DET
dti-1375	266	5	proliferation	proliferation	NOUN
dti-1375	266	6	stimulus	stimulus	NOUN
dti-1375	266	7	using	use	VERB
dti-1375	266	8	epidermal	epidermal	ADJ
dti-1375	266	9	growth	growth	NOUN
dti-1375	266	10	factor	factor	NOUN
dti-1375	266	11	(	(	PUNCT
dti-1375	266	12	egf	egf	PROPN
dti-1375	266	13	,	,	PUNCT
dti-1375	266	14	50	50	NUM
dti-1375	266	15	nm	nm	NOUN
dti-1375	266	16	)	)	PUNCT
dti-1375	266	17	on	on	ADP
dti-1375	266	18	senescent	senescent	ADJ
dti-1375	266	19	cells	cell	NOUN
dti-1375	266	20	.	.	PUNCT
dti-1375	267	1	egf	egf	PROPN
dti-1375	267	2	treatment	treatment	NOUN
dti-1375	267	3	increased	increase	VERB
dti-1375	267	4	subg1	subg1	ADJ
dti-1375	267	5	cells	cell	NOUN
dti-1375	267	6	by	by	ADP
dti-1375	267	7	decreasing	decrease	VERB
dti-1375	267	8	both	both	CCONJ
dti-1375	267	9	g1	g1	PROPN
dti-1375	267	10	/	/	SYM
dti-1375	267	11	s	s	NOUN
dti-1375	267	12	and	and	CCONJ
dti-1375	267	13	g2	g2	PROPN
dti-1375	267	14	/	/	SYM
dti-1375	267	15	m	m	PROPN
dti-1375	267	16	populations	population	NOUN
dti-1375	267	17	suggesting	suggest	VERB
dti-1375	267	18	enhanced	enhance	VERB
dti-1375	267	19	cytotoxicity	cytotoxicity	NOUN
dti-1375	267	20	(	(	PUNCT
dti-1375	267	21	fig	fig	NOUN
dti-1375	267	22	.	.	PUNCT
dti-1375	268	1	5b	5b	NUM
dti-1375	268	2	)	)	PUNCT
dti-1375	268	3	.	.	PUNCT
dti-1375	269	1	the	the	DET
dti-1375	269	2	mtor	mtor	NOUN
dti-1375	269	3	,	,	PUNCT
dti-1375	269	4	a	a	DET
dti-1375	269	5	serine	serine	NOUN
dti-1375	269	6	/	/	SYM
dti-1375	269	7	threonine	threonine	ADJ
dti-1375	269	8	kinase	kinase	NOUN
dti-1375	269	9	activation	activation	NOUN
dti-1375	269	10	favors	favor	VERB
dti-1375	269	11	senescence	senescence	NOUN
dti-1375	269	12	in	in	ADP
dti-1375	269	13	tumor	tumor	NOUN
dti-1375	269	14	cells.28	cells.28	NOUN
dti-1375	269	15	to	to	PART
dti-1375	269	16	investigate	investigate	VERB
dti-1375	269	17	the	the	DET
dti-1375	269	18	involvement	involvement	NOUN
dti-1375	269	19	of	of	ADP
dti-1375	269	20	mtor	mtor	NOUN
dti-1375	269	21	signaling	signal	VERB
dti-1375	269	22	in	in	ADP
dti-1375	269	23	senescence	senescence	NOUN
dti-1375	269	24	,	,	PUNCT
dti-1375	269	25	cells	cell	NOUN
dti-1375	269	26	were	be	AUX
dti-1375	269	27	treated	treat	VERB
dti-1375	269	28	with	with	ADP
dti-1375	269	29	mtor	mtor	PROPN
dti-1375	269	30	inhibitor	inhibitor	NOUN
dti-1375	269	31	,	,	PUNCT
dti-1375	269	32	rapamycin	rapamycin	VERB
dti-1375	269	33	for	for	ADP
dti-1375	269	34	48	48	NUM
dti-1375	269	35	h	h	NOUN
dti-1375	269	36	and	and	CCONJ
dti-1375	269	37	compared	compare	VERB
dti-1375	269	38	with	with	ADP
dti-1375	269	39	rapamycin	rapamycin	NOUN
dti-1375	269	40	(	(	PUNCT
dti-1375	269	41	200	200	NUM
dti-1375	269	42	nm	nm	NOUN
dti-1375	269	43	)	)	PUNCT
dti-1375	269	44	combined	combine	VERB
dti-1375	269	45	17aag	17aag	NOUN
dti-1375	269	46	pre	pre	NOUN
dti-1375	269	47	-	-	NOUN
dti-1375	269	48	treatments	treatment	NOUN
dti-1375	269	49	at	at	ADP
dti-1375	269	50	day	day	NOUN
dti-1375	269	51	2	2	NUM
dti-1375	269	52	,	,	PUNCT
dti-1375	269	53	4	4	NUM
dti-1375	269	54	,	,	PUNCT
dti-1375	269	55	and	and	CCONJ
dti-1375	269	56	6	6	NUM
dti-1375	269	57	using	use	VERB
dti-1375	269	58	facs	fac	NOUN
dti-1375	269	59	.	.	PUNCT
dti-1375	270	1	while	while	SCONJ
dti-1375	270	2	rapamycin	rapamycin	PROPN
dti-1375	270	3	had	have	VERB
dti-1375	270	4	no	no	DET
dti-1375	270	5	effect	effect	NOUN
dti-1375	270	6	on	on	ADP
dti-1375	270	7	control	control	NOUN
dti-1375	270	8	cells	cell	NOUN
dti-1375	270	9	,	,	PUNCT
dti-1375	270	10	its	its	PRON
dti-1375	270	11	treatment	treatment	NOUN
dti-1375	270	12	to	to	ADP
dti-1375	270	13	senescence	senescence	NOUN
dti-1375	270	14	directed	direct	VERB
dti-1375	270	15	cells	cell	NOUN
dti-1375	270	16	resulted	result	VERB
dti-1375	270	17	in	in	ADP
dti-1375	270	18	60	60	NUM
dti-1375	270	19	4	4	NUM
dti-1375	270	20	d	d	SYM
dti-1375	270	21	6	6	NUM
dti-1375	270	22	d	d	SYM
dti-1375	270	23	5	5	NUM
dti-1375	270	24	d	d	SYM
dti-1375	270	25	3	3	NUM
dti-1375	270	26	d	d	NOUN
dti-1375	270	27	a	a	DET
dti-1375	270	28	b	b	NOUN
dti-1375	270	29	c	c	NOUN
dti-1375	270	30	d	d	X
dti-1375	270	31	e	e	PROPN
dti-1375	270	32	f	f	PROPN
dti-1375	270	33	5	5	NUM
dti-1375	270	34	d	d	SYM
dti-1375	270	35	3	3	NUM
dti-1375	270	36	d	d	NOUN
dti-1375	270	37	17aag	17aag	NOUN
dti-1375	270	38	--	--	PUNCT
dti-1375	270	39	doxorubicin	doxorubicin	VERB
dti-1375	270	40	40	40	NUM
dti-1375	270	41	20	20	NUM
dti-1375	270	42	0	0	NUM
dti-1375	270	43	2.5	2.5	NUM
dti-1375	270	44	0	0	NUM
dti-1375	270	45	0	0	NUM
dti-1375	270	46	80	80	NUM
dti-1375	270	47	12	12	NUM
dti-1375	270	48	0	0	NUM
dti-1375	270	49	16	16	NUM
dti-1375	270	50	0	0	NUM
dti-1375	270	51	20	20	NUM
dti-1375	270	52	0	0	NUM
dti-1375	270	53	40	40	NUM
dti-1375	270	54	0	0	NUM
dti-1375	270	55	80	80	NUM
dti-1375	270	56	12	12	NUM
dti-1375	270	57	0	0	NUM
dti-1375	270	58	16	16	NUM
dti-1375	270	59	0	0	NUM
dti-1375	270	60	20	20	NUM
dti-1375	270	61	0	0	NUM
dti-1375	270	62	40	40	NUM
dti-1375	270	63	0	0	NUM
dti-1375	270	64	80	80	NUM
dti-1375	270	65	12	12	NUM
dti-1375	270	66	0	0	NUM
dti-1375	270	67	16	16	NUM
dti-1375	270	68	0	0	NUM
dti-1375	270	69	20	20	NUM
dti-1375	270	70	0	0	NUM
dti-1375	270	71	40	40	NUM
dti-1375	270	72	0	0	NUM
dti-1375	270	73	80	80	NUM
dti-1375	270	74	90	90	NUM
dti-1375	270	75	12	12	NUM
dti-1375	270	76	0	0	NUM
dti-1375	270	77	15	15	NUM
dti-1375	270	78	0	0	NUM
dti-1375	270	79	40	40	NUM
dti-1375	270	80	200	200	NUM
dti-1375	270	81	fl2a	fl2a	PROPN
dti-1375	270	82	fl2a	fl2a	PROPN
dti-1375	270	83	control	control	NOUN
dti-1375	270	84	−egf	−egf	PUNCT
dti-1375	271	1	g2	g2	PROPN
dti-1375	271	2	/	/	SYM
dti-1375	271	3	mg1	mg1	PROPN
dti-1375	271	4	/	/	SYM
dti-1375	271	5	s	s	PART
dti-1375	271	6	g2	g2	PROPN
dti-1375	271	7	/	/	SYM
dti-1375	271	8	mg1	mg1	PROPN
dti-1375	271	9	/	/	SYM
dti-1375	271	10	s	s	PART
dti-1375	271	11	−egf	−egf	NOUN
dti-1375	272	1	+	+	ADJ
dti-1375	272	2	egf+egf	egf+egf	PROPN
dti-1375	272	3	g2	g2	PROPN
dti-1375	272	4	/	/	SYM
dti-1375	272	5	mg1	mg1	PROPN
dti-1375	272	6	/	/	SYM
dti-1375	272	7	s	s	PART
dti-1375	272	8	g2	g2	PROPN
dti-1375	272	9	/	/	SYM
dti-1375	272	10	mg1	mg1	PROPN
dti-1375	272	11	/	/	SYM
dti-1375	272	12	s	s	PART
dti-1375	272	13	fl2a	fl2a	PROPN
dti-1375	272	14	c	c	NOUN
dti-1375	272	15	el	el	PROPN
dti-1375	272	16	l	l	PROPN
dti-1375	272	17	c	c	NOUN
dti-1375	272	18	o	o	X
dti-1375	272	19	u	u	NOUN
dti-1375	272	20	n	n	ADP
dti-1375	272	21	t	t	NOUN
dti-1375	272	22	c	c	PROPN
dti-1375	272	23	el	el	PROPN
dti-1375	272	24	l	l	PROPN
dti-1375	273	1	c	c	NOUN
dti-1375	273	2	o	o	X
dti-1375	273	3	u	u	NOUN
dti-1375	273	4	n	n	ADP
dti-1375	273	5	t	t	NOUN
dti-1375	273	6	c	c	PROPN
dti-1375	273	7	el	el	PROPN
dti-1375	273	8	l	l	PROPN
dti-1375	274	1	c	c	NOUN
dti-1375	274	2	o	o	X
dti-1375	274	3	u	u	NOUN
dti-1375	274	4	n	n	ADP
dti-1375	274	5	t	t	NOUN
dti-1375	274	6	c	c	PROPN
dti-1375	274	7	el	el	PROPN
dti-1375	274	8	l	l	PROPN
dti-1375	275	1	c	c	NOUN
dti-1375	275	2	o	o	X
dti-1375	275	3	u	u	NOUN
dti-1375	275	4	n	n	ADP
dti-1375	275	5	t	t	NOUN
dti-1375	275	6	fl2a	fl2a	NOUN
dti-1375	275	7	400	400	NUM
dti-1375	275	8	0	0	NUM
dti-1375	275	9	200	200	NUM
dti-1375	275	10	400	400	NUM
dti-1375	275	11	0	0	NUM
dti-1375	275	12	200	200	NUM
dti-1375	275	13	400	400	NUM
dti-1375	275	14	2.0	2.0	NUM
dti-1375	275	15	1.5	1.5	NUM
dti-1375	275	16	1.0	1.0	NUM
dti-1375	275	17	0.5	0.5	NUM
dti-1375	275	18	0	0	NUM
dti-1375	275	19	1.5	1.5	NUM
dti-1375	275	20	control	control	NOUN
dti-1375	275	21	17aag	17aag	NOUN
dti-1375	275	22	--	--	PUNCT
dti-1375	275	23	doxorubicin	doxorubicin	NOUN
dti-1375	275	24	2	2	NUM
dti-1375	275	25	d	d	SYM
dti-1375	275	26	4	4	NUM
dti-1375	275	27	d	d	SYM
dti-1375	275	28	6	6	NUM
dti-1375	275	29	d	d	NOUN
dti-1375	275	30	control	control	NOUN
dti-1375	275	31	p	p	X
dti-1375	275	32	<	<	X
dti-1375	275	33	0.05	0.05	NUM
dti-1375	275	34	p	p	NOUN
dti-1375	275	35	<	<	X
dti-1375	275	36	0.001	0.001	NUM
dti-1375	275	37	p	p	X
dti-1375	275	38	<	<	X
dti-1375	275	39	0.05	0.05	NUM
dti-1375	275	40	p	p	NOUN
dti-1375	275	41	<	<	X
dti-1375	275	42	0.001	0.001	NUM
dti-1375	275	43	p	p	X
dti-1375	275	44	<	<	X
dti-1375	275	45	0.001	0.001	NUM
dti-1375	275	46	p	p	X
dti-1375	275	47	<	<	X
dti-1375	275	48	0.001	0.001	NUM
dti-1375	275	49	3	3	NUM
dti-1375	275	50	d	d	SYM
dti-1375	275	51	3	3	NUM
dti-1375	275	52	d	d	NOUN
dti-1375	275	53	curcumin	curcumin	NOUN
dti-1375	275	54	r	r	NOUN
dti-1375	275	55	h	h	NOUN
dti-1375	275	56	12	12	NUM
dti-1375	275	57	3	3	NUM
dti-1375	275	58	ef	ef	PROPN
dti-1375	275	59	fl	fl	NUM
dti-1375	275	60	u	u	PROPN
dti-1375	275	61	x	x	X
dti-1375	275	62	ra	ra	PROPN
dti-1375	275	63	ti	ti	NOUN
dti-1375	275	64	o+	o+	NOUN
dti-1375	275	65	c	c	PROPN
dti-1375	275	66	u	u	PROPN
dti-1375	275	67	rc	rc	PROPN
dti-1375	275	68	u	u	NOUN
dti-1375	275	69	m	m	VERB
dti-1375	275	70	in	in	ADP
dti-1375	275	71	+	+	CCONJ
dti-1375	275	72	c	c	VERB
dti-1375	275	73	u	u	PROPN
dti-1375	275	74	rc	rc	PROPN
dti-1375	275	75	u	u	NOUN
dti-1375	275	76	m	m	VERB
dti-1375	275	77	in	in	ADP
dti-1375	275	78	+	+	CCONJ
dti-1375	275	79	c	c	VERB
dti-1375	275	80	u	u	PROPN
dti-1375	275	81	rc	rc	PROPN
dti-1375	275	82	u	u	NOUN
dti-1375	275	83	m	m	VERB
dti-1375	275	84	in	in	ADP
dti-1375	275	85	−	−	PROPN
dti-1375	275	86	c	c	NOUN
dti-1375	275	87	u	u	PROPN
dti-1375	275	88	rc	rc	PROPN
dti-1375	275	89	u	u	NOUN
dti-1375	275	90	m	m	VERB
dti-1375	275	91	in	in	ADP
dti-1375	275	92	−	−	PROPN
dti-1375	275	93	c	c	NOUN
dti-1375	275	94	u	u	PROPN
dti-1375	275	95	rc	rc	PROPN
dti-1375	275	96	u	u	NOUN
dti-1375	275	97	m	m	VERB
dti-1375	275	98	in	in	ADP
dti-1375	275	99	−	−	PROPN
dti-1375	275	100	c	c	NOUN
dti-1375	275	101	u	u	PROPN
dti-1375	275	102	rc	rc	PROPN
dti-1375	275	103	u	u	NOUN
dti-1375	275	104	m	m	VERB
dti-1375	275	105	in	in	ADP
dti-1375	275	106	4	4	NUM
dti-1375	275	107	d	d	SYM
dti-1375	275	108	4	4	NUM
dti-1375	275	109	d	d	NOUN
dti-1375	275	110	curcumin	curcumin	NOUN
dti-1375	275	111	5	5	NUM
dti-1375	275	112	d	d	SYM
dti-1375	275	113	5	5	NUM
dti-1375	275	114	d	d	PROPN
dti-1375	275	115	curcumin	curcumin	NOUN
dti-1375	275	116	mdr1	mdr1	PROPN
dti-1375	275	117	mrp1	mrp1	PROPN
dti-1375	275	118	mrp2	mrp2	PROPN
dti-1375	275	119	s28	s28	PROPN
dti-1375	275	120	1.0	1.0	NUM
dti-1375	275	121	0.5	0.5	NUM
dti-1375	275	122	0	0	NUM
dti-1375	275	123	1.5	1.5	NUM
dti-1375	275	124	1.0	1.0	NUM
dti-1375	275	125	0.5	0.5	NUM
dti-1375	275	126	0	0	NUM
dti-1375	275	127	1.5	1.5	NUM
dti-1375	275	128	1.0	1.0	NUM
dti-1375	275	129	0.5	0.5	NUM
dti-1375	275	130	0	0	NUM
dti-1375	275	131	m	m	NOUN
dti-1375	275	132	r	r	NOUN
dti-1375	275	133	p	p	NOUN
dti-1375	275	134	2/	2/	NUM
dti-1375	275	135	g	g	ADP
dti-1375	275	136	a	a	DET
dti-1375	275	137	p	p	X
dti-1375	275	138	d	d	X
dti-1375	275	139	h	h	NOUN
dti-1375	275	140	r	r	NOUN
dti-1375	275	141	at	at	ADP
dti-1375	275	142	io	io	X
dti-1375	275	143	m	m	PROPN
dti-1375	275	144	r	r	NOUN
dti-1375	275	145	p	p	PROPN
dti-1375	275	146	1/	1/	NUM
dti-1375	275	147	g	g	NOUN
dti-1375	275	148	a	a	DET
dti-1375	275	149	p	p	X
dti-1375	275	150	d	d	X
dti-1375	275	151	h	h	NOUN
dti-1375	275	152	r	r	NOUN
dti-1375	275	153	at	at	ADP
dti-1375	275	154	io	io	X
dti-1375	275	155	m	m	PROPN
dti-1375	275	156	r	r	NOUN
dti-1375	275	157	p	p	PROPN
dti-1375	275	158	1/	1/	NUM
dti-1375	275	159	g	g	NOUN
dti-1375	275	160	a	a	DET
dti-1375	275	161	p	p	X
dti-1375	275	162	d	d	X
dti-1375	275	163	h	h	NOUN
dti-1375	275	164	r	r	NOUN
dti-1375	275	165	at	at	ADP
dti-1375	275	166	io	io	PROPN
dti-1375	275	167	60	60	NUM
dti-1375	275	168	40	40	NUM
dti-1375	275	169	30	30	NUM
dti-1375	275	170	50	50	NUM
dti-1375	275	171	20	20	NUM
dti-1375	275	172	10	10	NUM
dti-1375	275	173	0	0	NUM
dti-1375	275	174	c	c	NOUN
dti-1375	275	175	2	2	NUM
dti-1375	275	176	d	d	SYM
dti-1375	275	177	4	4	NUM
dti-1375	275	178	d	d	NOUN
dti-1375	275	179	subg1	subg1	ADJ
dti-1375	275	180	in	in	ADP
dti-1375	275	181	cr	cr	PROPN
dti-1375	275	182	ea	ea	X
dti-1375	275	183	se	se	X
dti-1375	275	184	decrease	decrease	VERB
dti-1375	275	185	sub	sub	NOUN
dti-1375	275	186	-	-	NOUN
dti-1375	275	187	g	g	ADJ
dti-1375	275	188	1	1	NUM
dti-1375	275	189	g	g	NOUN
dti-1375	275	190	1	1	NUM
dti-1375	275	191	s	s	NOUN
dti-1375	275	192	sub	sub	NOUN
dti-1375	275	193	-	-	NOUN
dti-1375	275	194	g	g	ADJ
dti-1375	275	195	1	1	NUM
dti-1375	275	196	g	g	ADP
dti-1375	275	197	2	2	NUM
dti-1375	275	198	/	/	SYM
dti-1375	275	199	m	m	PROPN
dti-1375	275	200	g	g	NOUN
dti-1375	275	201	1	1	NUM
dti-1375	275	202	s	s	VERB
dti-1375	275	203	sub	sub	NOUN
dti-1375	275	204	-	-	NOUN
dti-1375	275	205	g	g	ADJ
dti-1375	275	206	1	1	NUM
dti-1375	275	207	g	g	ADP
dti-1375	275	208	2	2	NUM
dti-1375	275	209	/	/	SYM
dti-1375	275	210	m	m	PROPN
dti-1375	275	211	g	g	NOUN
dti-1375	275	212	1	1	NUM
dti-1375	275	213	s	s	VERB
dti-1375	275	214	sub	sub	NOUN
dti-1375	275	215	-	-	NOUN
dti-1375	275	216	g	g	ADJ
dti-1375	275	217	1	1	NUM
dti-1375	275	218	g	g	ADP
dti-1375	275	219	2	2	NUM
dti-1375	275	220	/	/	SYM
dti-1375	275	221	m	m	PROPN
dti-1375	275	222	g	g	NOUN
dti-1375	275	223	1	1	NUM
dti-1375	275	224	s	s	VERB
dti-1375	275	225	sub	sub	NOUN
dti-1375	275	226	-	-	NOUN
dti-1375	275	227	g	g	ADJ
dti-1375	275	228	1	1	NUM
dti-1375	275	229	g	g	ADP
dti-1375	275	230	2	2	NUM
dti-1375	275	231	/	/	SYM
dti-1375	275	232	m	m	PROPN
dti-1375	275	233	g	g	NOUN
dti-1375	275	234	1	1	NUM
dti-1375	275	235	s	s	NOUN
dti-1375	275	236	g	g	PROPN
dti-1375	275	237	2	2	NUM
dti-1375	275	238	/	/	SYM
dti-1375	275	239	m	m	PROPN
dti-1375	275	240	p	p	NOUN
dti-1375	275	241	er	er	INTJ
dti-1375	275	242	ce	ce	PROPN
dti-1375	275	243	n	n	PROPN
dti-1375	275	244	t	t	PROPN
dti-1375	275	245	ce	ce	PROPN
dti-1375	275	246	lls	ll	VERB
dti-1375	275	247	p	p	X
dti-1375	275	248	er	er	INTJ
dti-1375	275	249	ce	ce	PROPN
dti-1375	275	250	n	n	PROPN
dti-1375	275	251	t	t	PROPN
dti-1375	275	252	ce	ce	PROPN
dti-1375	275	253	lls	lls	PROPN
dti-1375	275	254	g1	g1	PROPN
dti-1375	275	255	s	s	PROPN
dti-1375	275	256	g2	g2	PROPN
dti-1375	275	257	/	/	SYM
dti-1375	275	258	m	m	PROPN
dti-1375	275	259	6	6	NUM
dti-1375	275	260	d	d	NOUN
dti-1375	275	261	c	c	NOUN
dti-1375	275	262	2	2	NUM
dti-1375	275	263	d	d	SYM
dti-1375	275	264	4	4	NUM
dti-1375	275	265	d	d	SYM
dti-1375	275	266	6	6	NUM
dti-1375	275	267	d	d	NOUN
dti-1375	275	268	c	c	NOUN
dti-1375	275	269	4	4	NUM
dti-1375	275	270	d	d	SYM
dti-1375	275	271	6	6	NUM
dti-1375	275	272	d	d	PROPN
dti-1375	275	273	c2	c2	PROPN
dti-1375	275	274	d	d	PROPN
dti-1375	275	275	4	4	NUM
dti-1375	275	276	d	d	SYM
dti-1375	275	277	6	6	NUM
dti-1375	275	278	d2	d2	PROPN
dti-1375	275	279	d	d	PROPN
dti-1375	275	280	control	control	NOUN
dti-1375	275	281	rapamycin	rapamycin	NOUN
dti-1375	275	282	(	(	PUNCT
dti-1375	275	283	48	48	NUM
dti-1375	275	284	h	h	NOUN
dti-1375	275	285	)	)	PUNCT
dti-1375	275	286	2	2	NUM
dti-1375	275	287	d	d	SYM
dti-1375	275	288	4	4	NUM
dti-1375	275	289	d	d	SYM
dti-1375	275	290	6	6	NUM
dti-1375	275	291	d	d	NOUN
dti-1375	275	292	+	+	NUM
dti-1375	275	293	rapamycin	rapamycin	NOUN
dti-1375	275	294	(	(	PUNCT
dti-1375	275	295	48	48	NUM
dti-1375	275	296	h	h	NOUN
dti-1375	275	297	)	)	PUNCT
dti-1375	275	298	17aag	17aag	NOUN
dti-1375	275	299	figure	figure	NOUN
dti-1375	275	300	5	5	NUM
dti-1375	275	301	.	.	PUNCT
dti-1375	276	1	studies	study	NOUN
dti-1375	276	2	on	on	ADP
dti-1375	276	3	17aag	17aag	ADJ
dti-1375	276	4	pre	pre	ADJ
dti-1375	276	5	-	-	ADJ
dti-1375	276	6	treatment	treatment	ADJ
dti-1375	276	7	accelerated	accelerated	ADJ
dti-1375	276	8	senescence	senescence	NOUN
dti-1375	276	9	reversal	reversal	NOUN
dti-1375	276	10	.	.	PUNCT
dti-1375	277	1	(	(	PUNCT
dti-1375	277	2	a	a	X
dti-1375	277	3	)	)	PUNCT
dti-1375	277	4	cells	cell	NOUN
dti-1375	277	5	after	after	ADP
dti-1375	277	6	treatment	treatment	NOUN
dti-1375	277	7	with	with	ADP
dti-1375	277	8	respective	respective	ADJ
dti-1375	277	9	senescence	senescence	NOUN
dti-1375	277	10	inducers	inducer	NOUN
dti-1375	277	11	were	be	AUX
dti-1375	277	12	incubated	incubate	VERB
dti-1375	277	13	with	with	ADP
dti-1375	277	14	curcumin	curcumin	NOUN
dti-1375	277	15	for	for	ADP
dti-1375	277	16	24	24	NUM
dti-1375	277	17	h	h	NOUN
dti-1375	277	18	and	and	CCONJ
dti-1375	277	19	examined	examine	VERB
dti-1375	277	20	for	for	ADP
dti-1375	277	21	sa	sa	PROPN
dti-1375	277	22	-	-	PUNCT
dti-1375	277	23	β	β	NOUN
dti-1375	277	24	-	-	ADJ
dti-1375	277	25	gal	gal	ADJ
dti-1375	277	26	positive	positive	ADJ
dti-1375	277	27	cells	cell	NOUN
dti-1375	277	28	.	.	PUNCT
dti-1375	278	1	(	(	PUNCT
dti-1375	278	2	b	b	X
dti-1375	278	3	)	)	PUNCT
dti-1375	278	4	cells	cell	NOUN
dti-1375	278	5	after	after	ADP
dti-1375	278	6	day	day	NOUN
dti-1375	278	7	6	6	NUM
dti-1375	278	8	of	of	ADP
dti-1375	278	9	the	the	DET
dti-1375	278	10	treatment	treatment	NOUN
dti-1375	278	11	were	be	AUX
dti-1375	278	12	stimulated	stimulate	VERB
dti-1375	278	13	with	with	ADP
dti-1375	278	14	egf	egf	PROPN
dti-1375	278	15	for	for	ADP
dti-1375	278	16	24	24	NUM
dti-1375	278	17	h	h	NOUN
dti-1375	278	18	and	and	CCONJ
dti-1375	278	19	analyzed	analyze	VERB
dti-1375	278	20	by	by	ADP
dti-1375	278	21	facs	fac	NOUN
dti-1375	278	22	.	.	PUNCT
dti-1375	279	1	(	(	PUNCT
dti-1375	279	2	c	c	X
dti-1375	279	3	)	)	PUNCT
dti-1375	279	4	senescent	senescent	ADJ
dti-1375	279	5	ells	ell	NOUN
dti-1375	279	6	were	be	AUX
dti-1375	279	7	incubated	incubate	VERB
dti-1375	279	8	with	with	ADP
dti-1375	279	9	rapamycin	rapamycin	NOUN
dti-1375	279	10	for	for	ADP
dti-1375	279	11	48	48	NUM
dti-1375	279	12	h	h	NOUN
dti-1375	279	13	and	and	CCONJ
dti-1375	279	14	analyzed	analyze	VERB
dti-1375	279	15	by	by	ADP
dti-1375	279	16	facs	fac	NOUN
dti-1375	279	17	.	.	PUNCT
dti-1375	280	1	(	(	PUNCT
dti-1375	280	2	d	d	X
dti-1375	280	3	)	)	PUNCT
dti-1375	280	4	cells	cell	NOUN
dti-1375	280	5	were	be	AUX
dti-1375	280	6	incubated	incubate	VERB
dti-1375	280	7	with	with	ADP
dti-1375	280	8	wortmanin	wortmanin	PROPN
dti-1375	280	9	for	for	ADP
dti-1375	280	10	18	18	NUM
dti-1375	280	11	h	h	NOUN
dti-1375	280	12	and	and	CCONJ
dti-1375	280	13	analyzed	analyze	VERB
dti-1375	280	14	by	by	ADP
dti-1375	280	15	facs	fac	NOUN
dti-1375	280	16	.	.	PUNCT
dti-1375	281	1	(	(	PUNCT
dti-1375	281	2	e	e	X
dti-1375	281	3	)	)	PUNCT
dti-1375	281	4	rh123	rh123	NOUN
dti-1375	281	5	efflux	efflux	NOUN
dti-1375	281	6	was	be	AUX
dti-1375	281	7	calculated	calculate	VERB
dti-1375	281	8	in	in	ADP
dti-1375	281	9	presence	presence	NOUN
dti-1375	281	10	and	and	CCONJ
dti-1375	281	11	absence	absence	NOUN
dti-1375	281	12	of	of	ADP
dti-1375	281	13	2	2	NUM
dti-1375	281	14	h	h	NOUN
dti-1375	281	15	pre	pre	NOUN
dti-1375	281	16	-	-	NOUN
dti-1375	281	17	incubation	incubation	NOUN
dti-1375	281	18	with	with	ADP
dti-1375	281	19	curcumin	curcumin	NOUN
dti-1375	281	20	.	.	PUNCT
dti-1375	282	1	cyclosporin	cyclosporin	PROPN
dti-1375	282	2	a	a	PRON
dti-1375	282	3	was	be	AUX
dti-1375	282	4	used	use	VERB
dti-1375	282	5	to	to	PART
dti-1375	282	6	study	study	VERB
dti-1375	282	7	the	the	DET
dti-1375	282	8	maximum	maximum	ADJ
dti-1375	282	9	retention	retention	NOUN
dti-1375	282	10	of	of	ADP
dti-1375	282	11	rh123	rh123	PROPN
dti-1375	282	12	.	.	PUNCT
dti-1375	283	1	(	(	PUNCT
dti-1375	283	2	f	f	X
dti-1375	283	3	)	)	PUNCT
dti-1375	283	4	rt	rt	ADJ
dti-1375	283	5	-	-	PUNCT
dti-1375	283	6	pcr	pcr	ADJ
dti-1375	283	7	analyses	analysis	NOUN
dti-1375	283	8	of	of	ADP
dti-1375	283	9	mdr1	mdr1	PROPN
dti-1375	283	10	,	,	PUNCT
dti-1375	283	11	mrp1	mrp1	NOUN
dti-1375	283	12	and	and	CCONJ
dti-1375	283	13	mrp2	mrp2	PROPN
dti-1375	283	14	of	of	ADP
dti-1375	283	15	cells	cell	NOUN
dti-1375	283	16	after	after	ADP
dti-1375	283	17	17aag	17aag	ADJ
dti-1375	283	18	pre	pre	NOUN
dti-1375	283	19	-	-	NOUN
dti-1375	283	20	treatment	treatment	NOUN
dti-1375	283	21	.	.	PUNCT
dti-1375	284	1	s28	s28	PROPN
dti-1375	284	2	rna	rna	PROPN
dti-1375	284	3	vs.	vs.	ADP
dti-1375	284	4	individual	individual	ADJ
dti-1375	284	5	gene	gene	NOUN
dti-1375	284	6	expression	expression	NOUN
dti-1375	284	7	ratios	ratio	NOUN
dti-1375	284	8	were	be	AUX
dti-1375	284	9	represented	represent	VERB
dti-1375	284	10	in	in	ADP
dti-1375	284	11	the	the	DET
dti-1375	284	12	bar	bar	NOUN
dti-1375	284	13	diagram	diagram	NOUN
dti-1375	284	14	.	.	PUNCT
dti-1375	285	1	http://www.la-press.com	http://www.la-press.com	X
dti-1375	286	1	sarangi	sarangi	PROPN
dti-1375	286	2	et	et	PROPN
dti-1375	286	3	al	al	PROPN
dti-1375	286	4	30	30	NUM
dti-1375	286	5	drug	drug	NOUN
dti-1375	286	6	target	target	NOUN
dti-1375	286	7	insights	insight	NOUN
dti-1375	286	8	2012:6	2012:6	NUM
dti-1375	286	9	a	a	DET
dti-1375	286	10	decrease	decrease	NOUN
dti-1375	286	11	to	to	PART
dti-1375	286	12	g1	g1	VERB
dti-1375	286	13	and	and	CCONJ
dti-1375	286	14	increase	increase	VERB
dti-1375	286	15	to	to	ADP
dti-1375	286	16	subg1	subg1	ADJ
dti-1375	286	17	population	population	NOUN
dti-1375	286	18	suggesting	suggest	VERB
dti-1375	286	19	that	that	SCONJ
dti-1375	286	20	compromised	compromise	VERB
dti-1375	286	21	mtor	mtor	PROPN
dti-1375	286	22	functions	function	NOUN
dti-1375	286	23	compromises	compromise	VERB
dti-1375	286	24	cell	cell	NOUN
dti-1375	286	25	survival	survival	NOUN
dti-1375	286	26	(	(	PUNCT
dti-1375	286	27	fig	fig	NOUN
dti-1375	286	28	.	.	PUNCT
dti-1375	287	1	5c	5c	NOUN
dti-1375	287	2	,	,	PUNCT
dti-1375	287	3	p	p	NOUN
dti-1375	287	4	,	,	PUNCT
dti-1375	287	5	0.001	0.001	NUM
dti-1375	287	6	)	)	PUNCT
dti-1375	287	7	.	.	PUNCT
dti-1375	288	1	in	in	ADP
dti-1375	288	2	addition	addition	NOUN
dti-1375	288	3	to	to	ADP
dti-1375	288	4	mtor	mtor	PROPN
dti-1375	288	5	,	,	PUNCT
dti-1375	288	6	pi3	pi3	NOUN
dti-1375	288	7	serine	serine	NOUN
dti-1375	288	8	/	/	SYM
dti-1375	288	9	threonine	threonine	ADJ
dti-1375	288	10	kinase	kinase	NOUN
dti-1375	288	11	(	(	PUNCT
dti-1375	288	12	pi3k	pi3k	PROPN
dti-1375	288	13	)	)	PUNCT
dti-1375	288	14	has	have	AUX
dti-1375	288	15	been	be	AUX
dti-1375	288	16	implicated	implicate	VERB
dti-1375	288	17	in	in	ADP
dti-1375	288	18	senescence.28	senescence.28	PROPN
dti-1375	288	19	therefore	therefore	ADV
dti-1375	288	20	,	,	PUNCT
dti-1375	288	21	we	we	PRON
dti-1375	288	22	looked	look	VERB
dti-1375	288	23	for	for	ADP
dti-1375	288	24	the	the	DET
dti-1375	288	25	effect	effect	NOUN
dti-1375	288	26	of	of	ADP
dti-1375	288	27	pi3k	pi3k	PROPN
dti-1375	288	28	inhibitor	inhibitor	NOUN
dti-1375	288	29	,	,	PUNCT
dti-1375	288	30	wortmanin	wortmanin	X
dti-1375	288	31	(	(	PUNCT
dti-1375	288	32	200	200	NUM
dti-1375	288	33	nm	nm	NOUN
dti-1375	288	34	)	)	PUNCT
dti-1375	288	35	on	on	ADP
dti-1375	288	36	senescent	senescent	ADJ
dti-1375	288	37	cells	cell	NOUN
dti-1375	288	38	by	by	ADP
dti-1375	288	39	using	use	VERB
dti-1375	288	40	facs	fac	NOUN
dti-1375	288	41	.	.	PUNCT
dti-1375	289	1	wortmanin	wortmanin	ADJ
dti-1375	289	2	treatment	treatment	NOUN
dti-1375	289	3	also	also	ADV
dti-1375	289	4	resulted	result	VERB
dti-1375	289	5	in	in	ADP
dti-1375	289	6	increased	increase	VERB
dti-1375	289	7	cell	cell	NOUN
dti-1375	289	8	death	death	NOUN
dti-1375	289	9	suggesting	suggest	VERB
dti-1375	289	10	its	its	PRON
dti-1375	289	11	role	role	NOUN
dti-1375	289	12	in	in	ADP
dti-1375	289	13	senescence	senescence	NOUN
dti-1375	289	14	cell	cell	NOUN
dti-1375	289	15	survival	survival	NOUN
dti-1375	289	16	(	(	PUNCT
dti-1375	289	17	fig	fig	NOUN
dti-1375	289	18	.	.	PUNCT
dti-1375	290	1	5d	5d	NUM
dti-1375	290	2	,	,	PUNCT
dti-1375	290	3	p	p	NOUN
dti-1375	290	4	,	,	PUNCT
dti-1375	290	5	0.001	0.001	NUM
dti-1375	290	6	)	)	PUNCT
dti-1375	290	7	.	.	PUNCT
dti-1375	291	1	enhanced	enhance	VERB
dti-1375	291	2	multidrug	multidrug	NOUN
dti-1375	291	3	resistance	resistance	NOUN
dti-1375	291	4	(	(	PUNCT
dti-1375	291	5	mdr	mdr	PROPN
dti-1375	291	6	)	)	PUNCT
dti-1375	291	7	is	be	AUX
dti-1375	291	8	one	one	NUM
dti-1375	291	9	of	of	ADP
dti-1375	291	10	the	the	DET
dti-1375	291	11	characteristic	characteristic	ADJ
dti-1375	291	12	features	feature	NOUN
dti-1375	291	13	of	of	ADP
dti-1375	291	14	senescent	senescent	ADJ
dti-1375	291	15	cells.29	cells.29	NOUN
dti-1375	291	16	to	to	PART
dti-1375	291	17	understand	understand	VERB
dti-1375	291	18	whether	whether	SCONJ
dti-1375	291	19	senescent	senescent	ADJ
dti-1375	291	20	cells	cell	NOUN
dti-1375	291	21	show	show	VERB
dti-1375	291	22	any	any	DET
dti-1375	291	23	enhanced	enhanced	ADJ
dti-1375	291	24	drug	drug	NOUN
dti-1375	291	25	resistance	resistance	NOUN
dti-1375	291	26	,	,	PUNCT
dti-1375	291	27	we	we	PRON
dti-1375	291	28	examined	examine	VERB
dti-1375	291	29	for	for	ADP
dti-1375	291	30	rh123	rh123	PROPN
dti-1375	291	31	efflux	efflux	NOUN
dti-1375	291	32	of	of	ADP
dti-1375	291	33	cells	cell	NOUN
dti-1375	291	34	from	from	ADP
dti-1375	291	35	day	day	NOUN
dti-1375	291	36	3	3	NUM
dti-1375	291	37	,	,	PUNCT
dti-1375	291	38	4	4	NUM
dti-1375	291	39	and	and	CCONJ
dti-1375	291	40	5	5	NUM
dti-1375	291	41	of	of	ADP
dti-1375	291	42	the	the	DET
dti-1375	291	43	treatment	treatment	NOUN
dti-1375	291	44	.	.	PUNCT
dti-1375	292	1	since	since	SCONJ
dti-1375	292	2	curcumin	curcumin	NOUN
dti-1375	292	3	interferes	interfere	VERB
dti-1375	292	4	with	with	ADP
dti-1375	292	5	mdr	mdr	PROPN
dti-1375	292	6	functions	function	NOUN
dti-1375	292	7	,	,	PUNCT
dti-1375	292	8	curcumin	curcumin	NOUN
dti-1375	292	9	was	be	AUX
dti-1375	292	10	used	use	VERB
dti-1375	292	11	(	(	PUNCT
dti-1375	292	12	2	2	NUM
dti-1375	292	13	h	h	NOUN
dti-1375	292	14	pre	pre	NOUN
dti-1375	292	15	-	-	NOUN
dti-1375	292	16	treatment	treatment	NOUN
dti-1375	292	17	prior	prior	ADV
dti-1375	292	18	to	to	ADP
dti-1375	292	19	rh123	rh123	PROPN
dti-1375	292	20	efflux	efflux	VERB
dti-1375	292	21	assay	assay	PROPN
dti-1375	292	22	)	)	PUNCT
dti-1375	292	23	to	to	PART
dti-1375	292	24	inhibit	inhibit	VERB
dti-1375	292	25	mdr	mdr	PROPN
dti-1375	292	26	functions	function	NOUN
dti-1375	292	27	.	.	PUNCT
dti-1375	293	1	compared	compare	VERB
dti-1375	293	2	to	to	PART
dti-1375	293	3	control	control	VERB
dti-1375	293	4	efflux	efflux	NOUN
dti-1375	293	5	ratio	ratio	NOUN
dti-1375	293	6	,	,	PUNCT
dti-1375	293	7	which	which	PRON
dti-1375	293	8	was	be	AUX
dti-1375	293	9	due	due	ADJ
dti-1375	293	10	to	to	ADP
dti-1375	293	11	constitutive	constitutive	ADJ
dti-1375	293	12	mdr	mdr	NOUN
dti-1375	293	13	activation	activation	NOUN
dti-1375	293	14	in	in	ADP
dti-1375	293	15	imr-32	imr-32	ADP
dti-1375	293	16	(	(	PUNCT
dti-1375	293	17	9	9	NUM
dti-1375	293	18	)	)	PUNCT
dti-1375	293	19	,	,	PUNCT
dti-1375	293	20	3	3	NUM
dti-1375	293	21	-	-	PUNCT
dti-1375	293	22	day	day	NOUN
dti-1375	293	23	treatments	treatment	NOUN
dti-1375	293	24	showed	show	VERB
dti-1375	293	25	increased	increase	VERB
dti-1375	293	26	efflux	efflux	NOUN
dti-1375	293	27	ratio	ratio	NOUN
dti-1375	293	28	by	by	ADP
dti-1375	293	29	0.5	0.5	NUM
dti-1375	293	30	folds	fold	NOUN
dti-1375	293	31	,	,	PUNCT
dti-1375	293	32	suggesting	suggest	VERB
dti-1375	293	33	enhanced	enhanced	ADJ
dti-1375	293	34	functions	function	NOUN
dti-1375	293	35	of	of	ADP
dti-1375	293	36	mdr	mdr	PROPN
dti-1375	293	37	on	on	ADP
dti-1375	293	38	the	the	DET
dti-1375	293	39	onset	onset	NOUN
dti-1375	293	40	of	of	ADP
dti-1375	293	41	senescence	senescence	NOUN
dti-1375	293	42	.	.	PUNCT
dti-1375	294	1	further	far	ADV
dti-1375	294	2	,	,	PUNCT
dti-1375	294	3	curcumin	curcumin	PROPN
dti-1375	294	4	was	be	AUX
dti-1375	294	5	effective	effective	ADJ
dti-1375	294	6	in	in	ADP
dti-1375	294	7	decreasing	decrease	VERB
dti-1375	294	8	mdr	mdr	NOUN
dti-1375	294	9	functions	function	NOUN
dti-1375	294	10	as	as	SCONJ
dti-1375	294	11	observed	observe	VERB
dti-1375	294	12	by	by	ADP
dti-1375	294	13	rh123	rh123	PROPN
dti-1375	294	14	efflux	efflux	PROPN
dti-1375	294	15	(	(	PUNCT
dti-1375	294	16	fig	fig	NOUN
dti-1375	294	17	.	.	PUNCT
dti-1375	295	1	5e	5e	NOUN
dti-1375	295	2	)	)	PUNCT
dti-1375	295	3	.	.	PUNCT
dti-1375	296	1	concurrently	concurrently	ADV
dti-1375	296	2	,	,	PUNCT
dti-1375	296	3	decreased	decrease	VERB
dti-1375	296	4	mdr1	mdr1	PROPN
dti-1375	296	5	expression	expression	NOUN
dti-1375	296	6	by	by	ADP
dti-1375	296	7	4	4	NUM
dti-1375	296	8	-	-	PUNCT
dti-1375	296	9	days	day	NOUN
dti-1375	296	10	and	and	CCONJ
dti-1375	296	11	its	its	PRON
dti-1375	296	12	re	re	NOUN
dti-1375	296	13	-	-	NOUN
dti-1375	296	14	expression	expression	NOUN
dti-1375	296	15	by	by	ADP
dti-1375	296	16	6	6	NUM
dti-1375	296	17	-	-	PUNCT
dti-1375	296	18	days	day	NOUN
dti-1375	296	19	were	be	AUX
dti-1375	296	20	observed	observe	VERB
dti-1375	296	21	.	.	PUNCT
dti-1375	297	1	the	the	DET
dti-1375	297	2	chronic	chronic	ADJ
dti-1375	297	3	expressions	expression	NOUN
dti-1375	297	4	of	of	ADP
dti-1375	297	5	multidrug	multidrug	NOUN
dti-1375	297	6	related	relate	VERB
dti-1375	297	7	proteins	protein	NOUN
dti-1375	297	8	,	,	PUNCT
dti-1375	297	9	mrp1	mrp1	NOUN
dti-1375	297	10	and	and	CCONJ
dti-1375	297	11	mrp2	mrp2	PROPN
dti-1375	297	12	were	be	AUX
dti-1375	297	13	however	however	ADV
dti-1375	297	14	,	,	PUNCT
dti-1375	297	15	not	not	PART
dti-1375	297	16	affected	affect	VERB
dti-1375	297	17	by	by	ADP
dti-1375	297	18	senescence	senescence	NOUN
dti-1375	297	19	activation	activation	NOUN
dti-1375	297	20	(	(	PUNCT
dti-1375	297	21	fig	fig	NOUN
dti-1375	297	22	.	.	PUNCT
dti-1375	297	23	5f	5f	NOUN
dti-1375	297	24	)	)	PUNCT
dti-1375	297	25	.	.	PUNCT
dti-1375	298	1	the	the	DET
dti-1375	298	2	representative	representative	ADJ
dti-1375	298	3	image	image	NOUN
dti-1375	298	4	j	j	PROPN
dti-1375	298	5	analysis	analysis	NOUN
dti-1375	298	6	of	of	ADP
dti-1375	298	7	gene	gene	NOUN
dti-1375	298	8	expression	expression	NOUN
dti-1375	298	9	versus	versus	ADP
dti-1375	298	10	gapdh	gapdh	NOUN
dti-1375	298	11	was	be	AUX
dti-1375	298	12	shown	show	VERB
dti-1375	298	13	in	in	ADP
dti-1375	298	14	bar	bar	NOUN
dti-1375	298	15	diagram	diagram	NOUN
dti-1375	298	16	.	.	PUNCT
dti-1375	299	1	senescent	senescent	ADJ
dti-1375	299	2	cells	cell	NOUN
dti-1375	299	3	show	show	VERB
dti-1375	299	4	compromised	compromise	VERB
dti-1375	299	5	colony	colony	NOUN
dti-1375	299	6	forming	form	VERB
dti-1375	299	7	ability	ability	NOUN
dti-1375	299	8	and	and	CCONJ
dti-1375	299	9	neo	neo	NOUN
dti-1375	299	10	-	-	NOUN
dti-1375	299	11	vascularization	vascularization	NOUN
dti-1375	299	12	it	it	PRON
dti-1375	299	13	was	be	AUX
dti-1375	299	14	reported	report	VERB
dti-1375	299	15	that	that	SCONJ
dti-1375	299	16	only	only	ADV
dti-1375	299	17	a	a	DET
dti-1375	299	18	subset	subset	NOUN
dti-1375	299	19	of	of	ADP
dti-1375	299	20	cancer	cancer	NOUN
dti-1375	299	21	cells	cell	NOUN
dti-1375	299	22	respond	respond	VERB
dti-1375	299	23	to	to	ADP
dti-1375	299	24	drug	drug	NOUN
dti-1375	299	25	induced	induce	VERB
dti-1375	299	26	cellular	cellular	ADJ
dti-1375	299	27	senescence	senescence	NOUN
dti-1375	299	28	and	and	CCONJ
dti-1375	299	29	remaining	remain	VERB
dti-1375	299	30	cells	cell	NOUN
dti-1375	299	31	retain	retain	VERB
dti-1375	299	32	metastatic	metastatic	ADJ
dti-1375	299	33	potential	potential	NOUN
dti-1375	299	34	and	and	CCONJ
dti-1375	299	35	lead	lead	VERB
dti-1375	299	36	to	to	PART
dti-1375	299	37	recurrence.30,31	recurrence.30,31	VERB
dti-1375	299	38	to	to	PART
dti-1375	299	39	exclude	exclude	VERB
dti-1375	299	40	the	the	DET
dti-1375	299	41	possibility	possibility	NOUN
dti-1375	299	42	of	of	ADP
dti-1375	299	43	tumor	tumor	NOUN
dti-1375	299	44	relapse	relapse	NOUN
dti-1375	299	45	in	in	ADP
dti-1375	299	46	our	our	PRON
dti-1375	299	47	senescence	senescence	NOUN
dti-1375	299	48	model	model	NOUN
dti-1375	299	49	,	,	PUNCT
dti-1375	299	50	first	first	ADV
dti-1375	299	51	we	we	PRON
dti-1375	299	52	examined	examine	VERB
dti-1375	299	53	anchorage	anchorage	NOUN
dti-1375	299	54	-	-	PUNCT
dti-1375	299	55	independent	independent	ADJ
dti-1375	299	56	cell	cell	NOUN
dti-1375	299	57	growth	growth	NOUN
dti-1375	299	58	using	use	VERB
dti-1375	299	59	soft	soft	ADJ
dti-1375	299	60	agar	agar	NOUN
dti-1375	299	61	colony	colony	NOUN
dti-1375	299	62	formation	formation	NOUN
dti-1375	299	63	assay	assay	VERB
dti-1375	299	64	.	.	PUNCT
dti-1375	300	1	cells	cell	NOUN
dti-1375	300	2	from	from	ADP
dti-1375	300	3	post	post	PROPN
dti-1375	300	4	17aag	17aag	ADJ
dti-1375	300	5	pre	pre	NOUN
dti-1375	300	6	-	-	NOUN
dti-1375	300	7	treatments	treatment	NOUN
dti-1375	300	8	at	at	ADP
dti-1375	300	9	day	day	NOUN
dti-1375	300	10	2	2	NUM
dti-1375	300	11	,	,	PUNCT
dti-1375	300	12	4	4	NUM
dti-1375	300	13	and	and	CCONJ
dti-1375	300	14	6	6	NUM
dti-1375	300	15	were	be	AUX
dti-1375	300	16	placed	place	VERB
dti-1375	300	17	on	on	ADP
dti-1375	300	18	agarose	agarose	NOUN
dti-1375	300	19	coated	coat	VERB
dti-1375	300	20	surface	surface	NOUN
dti-1375	300	21	and	and	CCONJ
dti-1375	300	22	the	the	DET
dti-1375	300	23	proliferation	proliferation	NOUN
dti-1375	300	24	potential	potential	NOUN
dti-1375	300	25	of	of	ADP
dti-1375	300	26	cells	cell	NOUN
dti-1375	300	27	was	be	AUX
dti-1375	300	28	monitored	monitor	VERB
dti-1375	300	29	for	for	ADP
dti-1375	300	30	colony	colony	NOUN
dti-1375	300	31	forming	form	VERB
dti-1375	300	32	ability	ability	NOUN
dti-1375	300	33	.	.	PUNCT
dti-1375	301	1	cells	cell	NOUN
dti-1375	301	2	collected	collect	VERB
dti-1375	301	3	on	on	ADP
dti-1375	301	4	the	the	DET
dti-1375	301	5	onset	onset	NOUN
dti-1375	301	6	of	of	ADP
dti-1375	301	7	senescence	senescence	NOUN
dti-1375	301	8	showed	show	VERB
dti-1375	301	9	±65	±65	NOUN
dti-1375	301	10	%	%	ADJ
dti-1375	301	11	decrease	decrease	NOUN
dti-1375	301	12	in	in	ADP
dti-1375	301	13	colony	colony	NOUN
dti-1375	301	14	size	size	NOUN
dti-1375	301	15	(	(	PUNCT
dti-1375	301	16	fig	fig	NOUN
dti-1375	301	17	.	.	PUNCT
dti-1375	301	18	6a	6a	NOUN
dti-1375	301	19	and	and	CCONJ
dti-1375	301	20	6a1	6a1	NUM
dti-1375	301	21	)	)	PUNCT
dti-1375	301	22	.	.	PUNCT
dti-1375	302	1	next	next	ADV
dti-1375	302	2	,	,	PUNCT
dti-1375	302	3	we	we	PRON
dti-1375	302	4	examined	examine	VERB
dti-1375	302	5	for	for	ADP
dti-1375	302	6	neovascularization	neovascularization	NOUN
dti-1375	302	7	after	after	ADP
dti-1375	302	8	growing	grow	VERB
dti-1375	302	9	cells	cell	NOUN
dti-1375	302	10	on	on	ADP
dti-1375	302	11	matrigel	matrigel	NOUN
dti-1375	302	12	coated	coat	VERB
dti-1375	302	13	surface	surface	NOUN
dti-1375	302	14	.	.	PUNCT
dti-1375	303	1	a	a	DET
dti-1375	303	2	6	6	NUM
dti-1375	303	3	-	-	PUNCT
dti-1375	303	4	day	day	NOUN
dti-1375	303	5	growth	growth	NOUN
dti-1375	303	6	of	of	ADP
dti-1375	303	7	control	control	NOUN
dti-1375	303	8	cells	cell	NOUN
dti-1375	303	9	on	on	ADP
dti-1375	303	10	matrigel	matrigel	NOUN
dti-1375	303	11	resulted	result	VERB
dti-1375	303	12	in	in	ADP
dti-1375	303	13	organized	organized	ADJ
dti-1375	303	14	large	large	ADJ
dti-1375	303	15	colonies	colony	NOUN
dti-1375	303	16	.	.	PUNCT
dti-1375	304	1	however	however	ADV
dti-1375	304	2	,	,	PUNCT
dti-1375	304	3	cells	cell	NOUN
dti-1375	304	4	from	from	ADP
dti-1375	304	5	the	the	DET
dti-1375	304	6	onset	onset	NOUN
dti-1375	304	7	of	of	ADP
dti-1375	304	8	senescence	senescence	NOUN
dti-1375	304	9	showed	show	VERB
dti-1375	304	10	a	a	DET
dti-1375	304	11	significant	significant	ADJ
dti-1375	304	12	decrease	decrease	NOUN
dti-1375	304	13	in	in	ADP
dti-1375	304	14	the	the	DET
dti-1375	304	15	organized	organize	VERB
dti-1375	304	16	colony	colony	NOUN
dti-1375	304	17	structures	structure	NOUN
dti-1375	304	18	(	(	PUNCT
dti-1375	304	19	fig	fig	NOUN
dti-1375	304	20	.	.	PUNCT
dti-1375	304	21	6b	6b	NUM
dti-1375	304	22	)	)	PUNCT
dti-1375	304	23	.	.	PUNCT
dti-1375	305	1	these	these	DET
dti-1375	305	2	findings	finding	NOUN
dti-1375	305	3	are	be	AUX
dti-1375	305	4	consistent	consistent	ADJ
dti-1375	305	5	with	with	ADP
dti-1375	305	6	sa	sa	PROPN
dti-1375	305	7	-	-	PUNCT
dti-1375	305	8	β	β	NOUN
dti-1375	305	9	-	-	ADJ
dti-1375	305	10	gal	gal	ADJ
dti-1375	305	11	data	datum	NOUN
dti-1375	305	12	that	that	PRON
dti-1375	305	13	a	a	DET
dti-1375	305	14	majority	majority	NOUN
dti-1375	305	15	of	of	ADP
dti-1375	305	16	cells	cell	NOUN
dti-1375	305	17	enter	enter	VERB
dti-1375	305	18	senescence	senescence	NOUN
dti-1375	305	19	state	state	NOUN
dti-1375	305	20	,	,	PUNCT
dti-1375	305	21	which	which	PRON
dti-1375	305	22	acts	act	VERB
dti-1375	305	23	as	as	ADP
dti-1375	305	24	an	an	DET
dti-1375	305	25	antiproliferative	antiproliferative	NOUN
dti-1375	305	26	and	and	CCONJ
dti-1375	305	27	anti	anti	ADJ
dti-1375	305	28	-	-	ADJ
dti-1375	305	29	metastatic	metastatic	ADJ
dti-1375	305	30	mechanism	mechanism	NOUN
dti-1375	305	31	.	.	PUNCT
dti-1375	306	1	cells	cell	NOUN
dti-1375	306	2	that	that	PRON
dti-1375	306	3	fail	fail	VERB
dti-1375	306	4	to	to	PART
dti-1375	306	5	enter	enter	VERB
dti-1375	306	6	senescence	senescence	NOUN
dti-1375	306	7	state	state	NOUN
dti-1375	306	8	were	be	AUX
dti-1375	306	9	found	find	VERB
dti-1375	306	10	to	to	PART
dti-1375	306	11	be	be	AUX
dti-1375	306	12	eliminated	eliminate	VERB
dti-1375	306	13	by	by	ADP
dti-1375	306	14	cytotoxicity	cytotoxicity	NOUN
dti-1375	306	15	(	(	PUNCT
dti-1375	306	16	compare	compare	VERB
dti-1375	306	17	fig	fig	NOUN
dti-1375	306	18	.	.	PUNCT
dti-1375	307	1	2	2	NUM
dti-1375	307	2	with	with	ADP
dti-1375	307	3	suppl	suppl	PROPN
dti-1375	307	4	.	.	PUNCT
dti-1375	307	5	fig	fig	PROPN
dti-1375	307	6	.	.	PUNCT
dti-1375	308	1	2b	2b	NUM
dti-1375	308	2	)	)	PUNCT
dti-1375	308	3	.	.	PUNCT
dti-1375	309	1	compromising	compromise	VERB
dti-1375	309	2	hsp90	hsp90	ADJ
dti-1375	309	3	expression	expression	NOUN
dti-1375	309	4	compromises	compromise	VERB
dti-1375	309	5	survival	survival	NOUN
dti-1375	309	6	potential	potential	NOUN
dti-1375	309	7	of	of	ADP
dti-1375	309	8	senescent	senescent	ADJ
dti-1375	309	9	cells	cell	NOUN
dti-1375	309	10	we	we	PRON
dti-1375	309	11	show	show	VERB
dti-1375	309	12	that	that	DET
dti-1375	309	13	interference	interference	NOUN
dti-1375	309	14	with	with	ADP
dti-1375	309	15	high	high	ADJ
dti-1375	309	16	affinity	affinity	NOUN
dti-1375	309	17	conformation	conformation	NOUN
dti-1375	309	18	of	of	ADP
dti-1375	309	19	hsp90	hsp90	PROPN
dti-1375	309	20	with	with	ADP
dti-1375	309	21	17aag32	17aag32	PROPN
dti-1375	309	22	accelerates	accelerate	VERB
dti-1375	309	23	doxorubicin	doxorubicin	PROPN
dti-1375	309	24	induced	induce	VERB
dti-1375	309	25	senescence	senescence	NOUN
dti-1375	309	26	.	.	PUNCT
dti-1375	310	1	in	in	ADP
dti-1375	310	2	these	these	DET
dti-1375	310	3	experiments	experiment	NOUN
dti-1375	310	4	17aag	17aag	ADJ
dti-1375	310	5	treatment	treatment	NOUN
dti-1375	310	6	per	per	X
dti-1375	310	7	se	se	X
dti-1375	310	8	will	will	AUX
dti-1375	310	9	not	not	PART
dti-1375	310	10	affect	affect	VERB
dti-1375	310	11	hsp90	hsp90	ADJ
dti-1375	310	12	expression	expression	NOUN
dti-1375	310	13	or	or	CCONJ
dti-1375	310	14	its	its	PRON
dti-1375	310	15	synthesis	synthesis	NOUN
dti-1375	310	16	,	,	PUNCT
dti-1375	310	17	but	but	CCONJ
dti-1375	310	18	interferes	interfere	VERB
dti-1375	310	19	with	with	ADP
dti-1375	310	20	its	its	PRON
dti-1375	310	21	high	high	ADJ
dti-1375	310	22	affinity	affinity	NOUN
dti-1375	310	23	conformation	conformation	NOUN
dti-1375	310	24	.	.	PUNCT
dti-1375	311	1	therefore	therefore	ADV
dti-1375	311	2	,	,	PUNCT
dti-1375	311	3	to	to	PART
dti-1375	311	4	study	study	VERB
dti-1375	311	5	whether	whether	SCONJ
dti-1375	311	6	compromised	compromise	VERB
dti-1375	311	7	hsp90	hsp90	ADJ
dti-1375	311	8	expression	expression	NOUN
dti-1375	311	9	will	will	AUX
dti-1375	311	10	have	have	VERB
dti-1375	311	11	any	any	DET
dti-1375	311	12	effect	effect	NOUN
dti-1375	311	13	on	on	ADP
dti-1375	311	14	senescence	senescence	NOUN
dti-1375	311	15	activation	activation	NOUN
dti-1375	311	16	,	,	PUNCT
dti-1375	311	17	imr-32	imr-32	SCONJ
dti-1375	311	18	cells	cell	NOUN
dti-1375	311	19	on	on	ADP
dti-1375	311	20	the	the	DET
dti-1375	311	21	onset	onset	NOUN
dti-1375	311	22	of	of	ADP
dti-1375	311	23	senescence	senescence	NOUN
dti-1375	311	24	were	be	AUX
dti-1375	311	25	transiently	transiently	ADV
dti-1375	311	26	transfected	transfecte	VERB
dti-1375	311	27	with	with	ADP
dti-1375	311	28	sirna	sirna	PROPN
dti-1375	311	29	to	to	PART
dti-1375	311	30	knockdown	knockdown	VERB
dti-1375	311	31	hsp90	hsp90	PROPN
dti-1375	311	32	(	(	PUNCT
dti-1375	311	33	2	2	NUM
dti-1375	311	34	µg/0.4	µg/0.4	NOUN
dti-1375	311	35	×	×	NOUN
dti-1375	311	36	106	106	NUM
dti-1375	311	37	cells	cell	NOUN
dti-1375	311	38	)	)	PUNCT
dti-1375	311	39	.	.	PUNCT
dti-1375	312	1	after	after	SCONJ
dti-1375	312	2	24	24	NUM
dti-1375	312	3	h	h	PROPN
dti-1375	312	4	sirna	sirna	PROPN
dti-1375	312	5	treatment	treatment	PROPN
dti-1375	312	6	,	,	PUNCT
dti-1375	312	7	knockdown	knockdown	NOUN
dti-1375	312	8	of	of	ADP
dti-1375	312	9	hsp90	hsp90	ADJ
dti-1375	312	10	expression	expression	NOUN
dti-1375	312	11	was	be	AUX
dti-1375	312	12	confirmed	confirm	VERB
dti-1375	312	13	by	by	ADP
dti-1375	312	14	examining	examine	VERB
dti-1375	312	15	the	the	DET
dti-1375	312	16	hsp90	hsp90	PROPN
dti-1375	312	17	mrna	mrna	PROPN
dti-1375	312	18	levels	level	NOUN
dti-1375	312	19	(	(	PUNCT
dti-1375	312	20	suppl	suppl	PROPN
dti-1375	312	21	.	.	PUNCT
dti-1375	312	22	fig	fig	PROPN
dti-1375	312	23	.	.	PUNCT
dti-1375	313	1	3	3	NUM
dti-1375	313	2	)	)	PUNCT
dti-1375	313	3	.	.	PUNCT
dti-1375	314	1	subsequently	subsequently	ADV
dti-1375	314	2	,	,	PUNCT
dti-1375	314	3	cells	cell	NOUN
dti-1375	314	4	were	be	AUX
dti-1375	314	5	tested	test	VERB
dti-1375	314	6	for	for	ADP
dti-1375	314	7	sa	sa	PROPN
dti-1375	314	8	-	-	PUNCT
dti-1375	314	9	β	β	NOUN
dti-1375	314	10	-	-	ADJ
dti-1375	314	11	gal	gal	ADJ
dti-1375	314	12	staining	staining	NOUN
dti-1375	314	13	and	and	CCONJ
dti-1375	314	14	cytotoxicity	cytotoxicity	NOUN
dti-1375	314	15	.	.	PUNCT
dti-1375	315	1	a	a	DET
dti-1375	315	2	significant	significant	ADJ
dti-1375	315	3	decrease	decrease	NOUN
dti-1375	315	4	in	in	ADP
dti-1375	315	5	sa	sa	PROPN
dti-1375	315	6	-	-	PUNCT
dti-1375	315	7	β	β	NOUN
dti-1375	315	8	-	-	ADJ
dti-1375	315	9	gal	gal	ADJ
dti-1375	315	10	positive	positive	ADJ
dti-1375	315	11	cells	cell	NOUN
dti-1375	315	12	in	in	ADP
dti-1375	315	13	day-2	day-2	NOUN
dti-1375	315	14	,	,	PUNCT
dti-1375	315	15	-4	-4	PUNCT
dti-1375	315	16	and	and	CCONJ
dti-1375	315	17	-6	-6	INTJ
dti-1375	315	18	(	(	PUNCT
dti-1375	315	19	fig	fig	NOUN
dti-1375	315	20	.	.	PUNCT
dti-1375	316	1	6c	6c	NOUN
dti-1375	316	2	and	and	CCONJ
dti-1375	316	3	d	d	NOUN
dti-1375	316	4	,	,	PUNCT
dti-1375	316	5	p	p	X
dti-1375	316	6	,	,	PUNCT
dti-1375	316	7	0.05	0.05	NUM
dti-1375	316	8	)	)	PUNCT
dti-1375	316	9	with	with	ADP
dti-1375	316	10	a	a	DET
dti-1375	316	11	concomitant	concomitant	ADJ
dti-1375	316	12	increase	increase	NOUN
dti-1375	316	13	in	in	ADP
dti-1375	316	14	cytotoxicity	cytotoxicity	NOUN
dti-1375	316	15	(	(	PUNCT
dti-1375	316	16	fig	fig	NOUN
dti-1375	316	17	.	.	PUNCT
dti-1375	317	1	6e	6e	NOUN
dti-1375	317	2	)	)	PUNCT
dti-1375	317	3	implied	imply	VERB
dti-1375	317	4	that	that	SCONJ
dti-1375	317	5	hsp90	hsp90	ADJ
dti-1375	317	6	expression	expression	NOUN
dti-1375	317	7	is	be	AUX
dti-1375	317	8	indispensible	indispensible	ADJ
dti-1375	317	9	for	for	ADP
dti-1375	317	10	cell	cell	NOUN
dti-1375	317	11	survival	survival	NOUN
dti-1375	317	12	.	.	PUNCT
dti-1375	318	1	chronic	chronic	ADJ
dti-1375	318	2	expression	expression	NOUN
dti-1375	318	3	of	of	ADP
dti-1375	318	4	hsp90	hsp90	PROPN
dti-1375	318	5	is	be	AUX
dti-1375	318	6	required	require	VERB
dti-1375	318	7	for	for	ADP
dti-1375	318	8	cell	cell	NOUN
dti-1375	318	9	survival	survival	NOUN
dti-1375	318	10	,	,	PUNCT
dti-1375	318	11	but	but	CCONJ
dti-1375	318	12	not	not	PART
dti-1375	318	13	the	the	DET
dti-1375	318	14	high	high	ADJ
dti-1375	318	15	affinity	affinity	NOUN
dti-1375	318	16	conformation	conformation	NOUN
dti-1375	318	17	,	,	PUNCT
dti-1375	318	18	where	where	SCONJ
dti-1375	318	19	the	the	DET
dti-1375	318	20	latter	latter	ADJ
dti-1375	318	21	is	be	AUX
dti-1375	318	22	involved	involve	VERB
dti-1375	318	23	in	in	ADP
dti-1375	318	24	oncogenic	oncogenic	ADJ
dti-1375	318	25	signal	signal	NOUN
dti-1375	318	26	transduction	transduction	NOUN
dti-1375	318	27	and	and	CCONJ
dti-1375	318	28	enhanced	enhance	VERB
dti-1375	318	29	cell	cell	NOUN
dti-1375	318	30	proliferation.32,33	proliferation.32,33	NOUN
dti-1375	318	31	cm	cm	NOUN
dti-1375	318	32	-	-	PUNCT
dti-1375	318	33	sasps	sasps	NOUN
dti-1375	318	34	from	from	ADP
dti-1375	318	35	senescent	senescent	ADJ
dti-1375	318	36	cells	cell	NOUN
dti-1375	318	37	induce	induce	VERB
dti-1375	318	38	senescence	senescence	NOUN
dti-1375	318	39	enforced	enforce	VERB
dti-1375	318	40	senescence	senescence	NOUN
dti-1375	318	41	in	in	ADP
dti-1375	318	42	tumor	tumor	NOUN
dti-1375	318	43	cells	cell	NOUN
dti-1375	318	44	has	have	AUX
dti-1375	318	45	also	also	ADV
dti-1375	318	46	been	be	AUX
dti-1375	318	47	proposed	propose	VERB
dti-1375	318	48	to	to	PART
dti-1375	318	49	be	be	AUX
dti-1375	318	50	deleterious	deleterious	ADJ
dti-1375	318	51	,	,	PUNCT
dti-1375	318	52	because	because	SCONJ
dti-1375	318	53	it	it	PRON
dti-1375	318	54	activates	activate	VERB
dti-1375	318	55	age	age	NOUN
dti-1375	318	56	-	-	PUNCT
dti-1375	318	57	associated	associate	VERB
dti-1375	318	58	pathologies.34	pathologies.34	NOUN
dti-1375	318	59	the	the	DET
dti-1375	318	60	genotoxic	genotoxic	ADJ
dti-1375	318	61	stress	stress	NOUN
dti-1375	318	62	enhances	enhance	VERB
dti-1375	318	63	senescence	senescence	NOUN
dti-1375	318	64	associated	associate	VERB
dti-1375	318	65	secretory	secretory	ADJ
dti-1375	318	66	phenotype	phenotype	NOUN
dti-1375	318	67	(	(	PUNCT
dti-1375	318	68	sasp	sasp	NOUN
dti-1375	318	69	)	)	PUNCT
dti-1375	318	70	,	,	PUNCT
dti-1375	318	71	which	which	PRON
dti-1375	318	72	however	however	ADV
dti-1375	318	73	,	,	PUNCT
dti-1375	318	74	is	be	AUX
dti-1375	318	75	linked	link	VERB
dti-1375	318	76	to	to	ADP
dti-1375	318	77	the	the	DET
dti-1375	318	78	loss	loss	NOUN
dti-1375	318	79	of	of	ADP
dti-1375	318	80	p53	p53	NOUN
dti-1375	318	81	function	function	NOUN
dti-1375	318	82	or	or	CCONJ
dti-1375	318	83	enhanced	enhance	VERB
dti-1375	318	84	oncogene	oncogene	NOUN
dti-1375	318	85	activation.35	activation.35	NOUN
dti-1375	318	86	since	since	SCONJ
dti-1375	318	87	,	,	PUNCT
dti-1375	318	88	imr-32	imr-32	ADV
dti-1375	318	89	http://www.la-press.com	http://www.la-press.com	X
dti-1375	318	90	hsp90	hsp90	ADJ
dti-1375	318	91	inhibition	inhibition	NOUN
dti-1375	318	92	accelerates	accelerate	VERB
dti-1375	318	93	senescence	senescence	NOUN
dti-1375	318	94	drug	drug	NOUN
dti-1375	318	95	target	target	NOUN
dti-1375	318	96	insights	insight	NOUN
dti-1375	319	1	2012:6	2012:6	NUM
dti-1375	319	2	31	31	NUM
dti-1375	319	3	b	b	SYM
dti-1375	319	4	4	4	NUM
dti-1375	319	5	d	d	SYM
dti-1375	319	6	1	1	NUM
dti-1375	319	7	d	d	SYM
dti-1375	319	8	2	2	NUM
dti-1375	319	9	d	d	SYM
dti-1375	319	10	6	6	NUM
dti-1375	319	11	d	d	NOUN
dti-1375	319	12	a1	a1	NOUN
dti-1375	319	13	a	a	DET
dti-1375	319	14	control	control	NOUN
dti-1375	319	15	17aag	17aag	NOUN
dti-1375	319	16	---	---	PUNCT
dti-1375	319	17	doxo	doxo	ADJ
dti-1375	319	18	17aag	17aag	NOUN
dti-1375	319	19	---	---	PUNCT
dti-1375	319	20	doxorubucin	doxorubucin	ADJ
dti-1375	319	21	17aag	17aag	NOUN
dti-1375	319	22	---	---	PUNCT
dti-1375	319	23	doxo	doxo	ADP
dti-1375	319	24	p	p	X
dti-1375	319	25	<	<	X
dti-1375	319	26	0.01	0.01	NUM
dti-1375	319	27	p	p	NOUN
dti-1375	319	28	<	<	X
dti-1375	319	29	0.001	0.001	NUM
dti-1375	319	30	p	p	X
dti-1375	319	31	<	<	X
dti-1375	319	32	0.01	0.01	NUM
dti-1375	319	33	p	p	X
dti-1375	319	34	<	<	X
dti-1375	319	35	0.01	0.01	NUM
dti-1375	319	36	p	p	NOUN
dti-1375	319	37	<	<	X
dti-1375	319	38	0.004	0.004	NUM
dti-1375	319	39	p	p	X
dti-1375	319	40	<	<	X
dti-1375	319	41	0.002	0.002	NUM
dti-1375	319	42	6	6	NUM
dti-1375	319	43	d4	d4	PROPN
dti-1375	319	44	d2	d2	PROPN
dti-1375	319	45	dcontrol	dcontrol	NOUN
dti-1375	319	46	control	control	NOUN
dti-1375	320	1	c	c	NOUN
dti-1375	320	2	o	o	INTJ
dti-1375	321	1	lo	lo	INTJ
dti-1375	321	2	n	n	CCONJ
dti-1375	321	3	y	y	PROPN
dti-1375	321	4	si	si	PROPN
dti-1375	321	5	ze	ze	PROPN
dti-1375	321	6	(	(	PUNCT
dti-1375	321	7	m	m	PROPN
dti-1375	321	8	ic	ic	PROPN
dti-1375	321	9	ro	ro	INTJ
dti-1375	321	10	m	m	VERB
dti-1375	321	11	et	et	NOUN
dti-1375	321	12	er	er	INTJ
dti-1375	321	13	s	s	PROPN
dti-1375	321	14	)	)	PUNCT
dti-1375	321	15	150	150	NUM
dti-1375	321	16	100	100	NUM
dti-1375	321	17	50	50	NUM
dti-1375	321	18	0	0	NUM
dti-1375	321	19	2	2	NUM
dti-1375	321	20	d	d	SYM
dti-1375	321	21	4	4	NUM
dti-1375	321	22	d	d	SYM
dti-1375	321	23	6	6	NUM
dti-1375	321	24	d	d	NOUN
dti-1375	321	25	c	c	NOUN
dti-1375	321	26	d	d	X
dti-1375	321	27	e	e	PROPN
dti-1375	321	28	epifluorescence	epifluorescence	NOUN
dti-1375	321	29	2	2	NUM
dti-1375	321	30	d	d	SYM
dti-1375	321	31	4	4	NUM
dti-1375	321	32	d	d	SYM
dti-1375	321	33	6	6	NUM
dti-1375	321	34	d	d	SYM
dti-1375	321	35	100	100	NUM
dti-1375	321	36	80	80	NUM
dti-1375	321	37	60	60	NUM
dti-1375	321	38	40	40	NUM
dti-1375	321	39	20	20	NUM
dti-1375	321	40	0	0	NUM
dti-1375	321	41	2	2	NUM
dti-1375	321	42	d	d	SYM
dti-1375	321	43	4	4	NUM
dti-1375	321	44	d	d	SYM
dti-1375	321	45	6	6	NUM
dti-1375	321	46	d	d	NOUN
dti-1375	321	47	β	β	NOUN
dti-1375	321	48	-	-	ADJ
dti-1375	321	49	galactosidase	galactosidase	ADJ
dti-1375	321	50	staining	stain	VERB
dti-1375	321	51	p	p	PROPN
dti-1375	321	52	er	er	INTJ
dti-1375	321	53	ce	ce	PROPN
dti-1375	321	54	n	n	PROPN
dti-1375	321	55	t	t	PROPN
dti-1375	321	56	βg	βg	VERB
dti-1375	321	57	al	al	PROPN
dti-1375	321	58	ac	ac	PROPN
dti-1375	321	59	to	to	ADP
dti-1375	321	60	si	si	PROPN
dti-1375	321	61	d	d	PROPN
dti-1375	321	62	as	as	ADP
dti-1375	321	63	e	e	X
dti-1375	321	64	p	p	NOUN
dti-1375	321	65	o	o	X
dti-1375	321	66	si	si	X
dti-1375	321	67	ti	ti	X
dti-1375	321	68	ve	ve	PROPN
dti-1375	321	69	c	c	PROPN
dti-1375	321	70	el	el	PROPN
dti-1375	321	71	ls	ls	ADJ
dti-1375	321	72	days	day	NOUN
dti-1375	321	73	after	after	ADP
dti-1375	321	74	the	the	DET
dti-1375	321	75	treatment	treatment	NOUN
dti-1375	321	76	100	100	NUM
dti-1375	321	77	80	80	NUM
dti-1375	321	78	60	60	NUM
dti-1375	321	79	40	40	NUM
dti-1375	321	80	20	20	NUM
dti-1375	321	81	0	0	NUM
dti-1375	321	82	2	2	NUM
dti-1375	321	83	dcontrol	dcontrol	NOUN
dti-1375	321	84	4	4	NUM
dti-1375	321	85	d	d	SYM
dti-1375	321	86	6	6	NUM
dti-1375	321	87	d	d	NOUN
dti-1375	321	88	p	p	X
dti-1375	321	89	er	er	INTJ
dti-1375	321	90	ce	ce	PROPN
dti-1375	321	91	n	n	ADP
dti-1375	321	92	t	t	X
dti-1375	321	93	cy	cy	VERB
dti-1375	321	94	to	to	PART
dti-1375	321	95	to	to	ADP
dti-1375	321	96	xi	xi	PROPN
dti-1375	321	97	ci	ci	PROPN
dti-1375	322	1	ty	ty	ADJ
dti-1375	322	2	days	day	NOUN
dti-1375	322	3	after	after	ADP
dti-1375	322	4	treatment	treatment	NOUN
dti-1375	322	5	figure	figure	NOUN
dti-1375	322	6	6	6	NUM
dti-1375	322	7	.	.	PUNCT
dti-1375	322	8	anti	anti	ADJ
dti-1375	322	9	-	-	ADJ
dti-1375	322	10	proliferative	proliferative	ADJ
dti-1375	322	11	/	/	SYM
dti-1375	322	12	anti	anti	ADJ
dti-1375	322	13	-	-	ADJ
dti-1375	322	14	neo	neo	ADJ
dti-1375	322	15	-	-	ADJ
dti-1375	322	16	vascularization	vascularization	NOUN
dti-1375	322	17	effects	effect	NOUN
dti-1375	322	18	of	of	ADP
dti-1375	322	19	17aag	17aag	ADJ
dti-1375	322	20	pre	pre	ADJ
dti-1375	322	21	-	-	ADJ
dti-1375	322	22	treatment	treatment	ADJ
dti-1375	322	23	accelerated	accelerate	VERB
dti-1375	322	24	senescence	senescence	NOUN
dti-1375	322	25	cells	cell	NOUN
dti-1375	322	26	.	.	PUNCT
dti-1375	323	1	(	(	PUNCT
dti-1375	323	2	a	a	X
dti-1375	323	3	)	)	PUNCT
dti-1375	323	4	anchorage	anchorage	NOUN
dti-1375	323	5	-	-	PUNCT
dti-1375	323	6	independent	independent	ADJ
dti-1375	323	7	cell	cell	NOUN
dti-1375	323	8	growth	growth	NOUN
dti-1375	323	9	analysis	analysis	NOUN
dti-1375	323	10	of	of	ADP
dti-1375	323	11	17aag	17aag	NOUN
dti-1375	323	12	pre	pre	ADJ
dti-1375	323	13	-	-	ADJ
dti-1375	323	14	treated	treat	VERB
dti-1375	323	15	cells	cell	NOUN
dti-1375	323	16	for	for	ADP
dti-1375	323	17	14	14	NUM
dti-1375	323	18	-	-	PUNCT
dti-1375	323	19	days	day	NOUN
dti-1375	323	20	on	on	ADP
dti-1375	323	21	agar	agar	NOUN
dti-1375	323	22	coated	coated	ADJ
dti-1375	323	23	plates	plate	NOUN
dti-1375	323	24	.	.	PUNCT
dti-1375	324	1	(	(	PUNCT
dti-1375	324	2	a1	a1	NOUN
dti-1375	324	3	)	)	PUNCT
dti-1375	324	4	increase	increase	NOUN
dti-1375	324	5	in	in	ADP
dti-1375	324	6	colony	colony	NOUN
dti-1375	324	7	size	size	NOUN
dti-1375	324	8	represents	represent	VERB
dti-1375	324	9	growth	growth	NOUN
dti-1375	324	10	stimulus	stimulus	NOUN
dti-1375	324	11	and	and	CCONJ
dti-1375	324	12	proliferation	proliferation	NOUN
dti-1375	324	13	potential	potential	NOUN
dti-1375	324	14	,	,	PUNCT
dti-1375	324	15	note	note	VERB
dti-1375	324	16	that	that	SCONJ
dti-1375	324	17	senescence	senescence	NOUN
dti-1375	324	18	cells	cell	NOUN
dti-1375	324	19	showing	show	VERB
dti-1375	324	20	decreased	decrease	VERB
dti-1375	324	21	proliferation	proliferation	NOUN
dti-1375	324	22	potential	potential	NOUN
dti-1375	324	23	.	.	PUNCT
dti-1375	325	1	(	(	PUNCT
dti-1375	325	2	b	b	X
dti-1375	325	3	)	)	PUNCT
dti-1375	325	4	anchorage	anchorage	NOUN
dti-1375	325	5	-	-	PUNCT
dti-1375	325	6	dependent	dependent	ADJ
dti-1375	325	7	growth	growth	NOUN
dti-1375	325	8	on	on	ADP
dti-1375	325	9	matrigel	matrigel	NOUN
dti-1375	325	10	coated	coat	VERB
dti-1375	325	11	glass	glass	NOUN
dti-1375	325	12	surface	surface	NOUN
dti-1375	325	13	.	.	PUNCT
dti-1375	326	1	note	note	VERB
dti-1375	326	2	a	a	DET
dti-1375	326	3	decrease	decrease	NOUN
dti-1375	326	4	in	in	ADP
dti-1375	326	5	organized	organized	ADJ
dti-1375	326	6	colonies	colony	NOUN
dti-1375	326	7	on	on	ADP
dti-1375	326	8	the	the	DET
dti-1375	326	9	onset	onset	NOUN
dti-1375	326	10	of	of	ADP
dti-1375	326	11	senescence	senescence	NOUN
dti-1375	326	12	.	.	PUNCT
dti-1375	327	1	(	(	PUNCT
dti-1375	327	2	c	c	X
dti-1375	327	3	)	)	PUNCT
dti-1375	327	4	effect	effect	NOUN
dti-1375	327	5	of	of	ADP
dti-1375	327	6	sirna	sirna	PROPN
dti-1375	327	7	knockdown	knockdown	NOUN
dti-1375	327	8	of	of	ADP
dti-1375	327	9	hsp90	hsp90	PROPN
dti-1375	327	10	on	on	ADP
dti-1375	327	11	sa	sa	NOUN
dti-1375	327	12	-	-	PUNCT
dti-1375	327	13	β	β	NOUN
dti-1375	327	14	-	-	ADJ
dti-1375	327	15	gal	gal	ADJ
dti-1375	327	16	positive	positive	ADJ
dti-1375	327	17	cells	cell	NOUN
dti-1375	327	18	on	on	ADP
dti-1375	327	19	17aag	17aag	ADJ
dti-1375	327	20	pre	pre	NOUN
dti-1375	327	21	-	-	NOUN
dti-1375	327	22	treatments	treatment	NOUN
dti-1375	327	23	.	.	PUNCT
dti-1375	328	1	(	(	PUNCT
dti-1375	328	2	d	d	X
dti-1375	328	3	)	)	PUNCT
dti-1375	328	4	counting	counting	NOUN
dti-1375	328	5	of	of	ADP
dti-1375	328	6	sa	sa	PROPN
dti-1375	328	7	-	-	PUNCT
dti-1375	328	8	β	β	NOUN
dti-1375	328	9	-	-	ADJ
dti-1375	328	10	gal	gal	ADJ
dti-1375	328	11	positive	positive	ADJ
dti-1375	328	12	cells	cell	NOUN
dti-1375	328	13	after	after	ADP
dti-1375	328	14	17aag	17aag	ADJ
dti-1375	328	15	pre	pre	NOUN
dti-1375	328	16	-	-	NOUN
dti-1375	328	17	treatments	treatment	NOUN
dti-1375	328	18	.	.	PUNCT
dti-1375	329	1	(	(	PUNCT
dti-1375	329	2	e	e	X
dti-1375	329	3	)	)	PUNCT
dti-1375	329	4	the	the	DET
dti-1375	329	5	cytotoxicity	cytotoxicity	NOUN
dti-1375	329	6	analysis	analysis	NOUN
dti-1375	329	7	of	of	ADP
dti-1375	329	8	sirna	sirna	PROPN
dti-1375	329	9	knockdown	knockdown	NOUN
dti-1375	329	10	of	of	ADP
dti-1375	329	11	hsp90	hsp90	PROPN
dti-1375	329	12	.	.	PUNCT
dti-1375	330	1	the	the	DET
dti-1375	330	2	increase	increase	NOUN
dti-1375	330	3	in	in	ADP
dti-1375	330	4	cytotoxicity	cytotoxicity	NOUN
dti-1375	330	5	was	be	AUX
dti-1375	330	6	assessed	assess	VERB
dti-1375	330	7	by	by	ADP
dti-1375	330	8	the	the	DET
dti-1375	330	9	accumulation	accumulation	NOUN
dti-1375	330	10	of	of	ADP
dti-1375	330	11	percent	percent	NOUN
dti-1375	330	12	subg1	subg1	ADJ
dti-1375	330	13	cells	cell	NOUN
dti-1375	330	14	.	.	PUNCT
dti-1375	331	1	exhibit	exhibit	VERB
dti-1375	331	2	functional	functional	ADJ
dti-1375	331	3	p53	p53	NOUN
dti-1375	331	4	and	and	CCONJ
dti-1375	331	5	chronic	chronic	ADJ
dti-1375	331	6	oncogene	oncogene	NOUN
dti-1375	331	7	activation	activation	NOUN
dti-1375	331	8	,	,	PUNCT
dti-1375	331	9	we	we	PRON
dti-1375	331	10	examined	examine	VERB
dti-1375	331	11	cm	cm	NOUN
dti-1375	331	12	containing	contain	VERB
dti-1375	331	13	sasps	sasp	NOUN
dti-1375	331	14	from	from	ADP
dti-1375	331	15	senescent	senescent	ADJ
dti-1375	331	16	cells	cell	NOUN
dti-1375	331	17	on	on	ADP
dti-1375	331	18	pro	pro	ADJ
dti-1375	331	19	-	-	ADJ
dti-1375	331	20	senescence	senescence	ADJ
dti-1375	331	21	activity	activity	NOUN
dti-1375	331	22	.	.	PUNCT
dti-1375	332	1	between	between	ADP
dti-1375	332	2	the	the	DET
dti-1375	332	3	two	two	NUM
dti-1375	332	4	cell	cell	NOUN
dti-1375	332	5	types	type	NOUN
dti-1375	332	6	used	use	VERB
dti-1375	332	7	in	in	ADP
dti-1375	332	8	our	our	PRON
dti-1375	332	9	study	study	NOUN
dti-1375	332	10	,	,	PUNCT
dti-1375	332	11	jurkat	jurkat	PROPN
dti-1375	332	12	cells	cell	NOUN
dti-1375	332	13	mimic	mimic	VERB
dti-1375	332	14	t	t	NOUN
dti-1375	332	15	-	-	PUNCT
dti-1375	332	16	cell	cell	NOUN
dti-1375	332	17	leukemia	leukemia	NOUN
dti-1375	332	18	and	and	CCONJ
dti-1375	332	19	secret	secret	ADJ
dti-1375	332	20	cytokines	cytokine	NOUN
dti-1375	332	21	,	,	PUNCT
dti-1375	332	22	whereas	whereas	SCONJ
dti-1375	332	23	,	,	PUNCT
dti-1375	332	24	sra01	sra01	NOUN
dti-1375	332	25	are	be	AUX
dti-1375	332	26	virus	virus	NOUN
dti-1375	332	27	free	free	ADJ
dti-1375	332	28	immortalized	immortalize	VERB
dti-1375	332	29	cells	cell	NOUN
dti-1375	332	30	containing	contain	VERB
dti-1375	332	31	progenitors	progenitor	NOUN
dti-1375	332	32	of	of	ADP
dti-1375	332	33	myoepithelial	myoepithelial	ADJ
dti-1375	332	34	lacking	lacking	ADJ
dti-1375	332	35	tumorigenic	tumorigenic	ADJ
dti-1375	332	36	activity	activity	NOUN
dti-1375	332	37	.	.	PUNCT
dti-1375	333	1	the	the	DET
dti-1375	333	2	cm	cm	PROPN
dti-1375	333	3	treated	treat	VERB
dti-1375	333	4	tumor	tumor	NOUN
dti-1375	333	5	cells	cell	NOUN
dti-1375	333	6	showed	show	VERB
dti-1375	333	7	senescence	senescence	NOUN
dti-1375	333	8	morphology	morphology	NOUN
dti-1375	333	9	by	by	ADP
dti-1375	333	10	4	4	NUM
dti-1375	333	11	-	-	PUNCT
dti-1375	333	12	day	day	NOUN
dti-1375	333	13	treatment	treatment	NOUN
dti-1375	333	14	as	as	SCONJ
dti-1375	333	15	observed	observe	VERB
dti-1375	333	16	by	by	ADP
dti-1375	333	17	sa	sa	PROPN
dti-1375	333	18	-	-	PUNCT
dti-1375	333	19	β	β	NOUN
dti-1375	333	20	-	-	ADJ
dti-1375	333	21	gal	gal	ADJ
dti-1375	333	22	staining	staining	NOUN
dti-1375	333	23	.	.	PUNCT
dti-1375	334	1	interestingly	interestingly	ADV
dti-1375	334	2	,	,	PUNCT
dti-1375	334	3	between	between	ADP
dti-1375	334	4	jurkat	jurkat	PROPN
dti-1375	334	5	and	and	CCONJ
dti-1375	334	6	sra01	sra01	NOUN
dti-1375	334	7	,	,	PUNCT
dti-1375	334	8	the	the	DET
dti-1375	334	9	sra01	sra01	NOUN
dti-1375	334	10	showed	show	VERB
dti-1375	334	11	50	50	NUM
dti-1375	334	12	%	%	NOUN
dti-1375	334	13	less	less	ADJ
dti-1375	334	14	sa	sa	NOUN
dti-1375	334	15	-	-	PUNCT
dti-1375	334	16	β	β	NOUN
dti-1375	334	17	-	-	ADJ
dti-1375	334	18	gal	gal	ADJ
dti-1375	334	19	positive	positive	ADJ
dti-1375	334	20	cells	cell	NOUN
dti-1375	334	21	,	,	PUNCT
dti-1375	334	22	however	however	ADV
dti-1375	334	23	,	,	PUNCT
dti-1375	334	24	were	be	AUX
dti-1375	334	25	associated	associate	VERB
dti-1375	334	26	with	with	ADP
dti-1375	334	27	enhanced	enhance	VERB
dti-1375	334	28	cytotoxicity	cytotoxicity	NOUN
dti-1375	334	29	.	.	PUNCT
dti-1375	335	1	these	these	DET
dti-1375	335	2	experiments	experiment	NOUN
dti-1375	335	3	suggested	suggest	VERB
dti-1375	335	4	that	that	SCONJ
dti-1375	335	5	the	the	DET
dti-1375	335	6	paracrine	paracrine	NOUN
dti-1375	335	7	activities	activity	NOUN
dti-1375	335	8	of	of	ADP
dti-1375	335	9	sasps	sasp	NOUN
dti-1375	335	10	in	in	ADP
dti-1375	335	11	our	our	PRON
dti-1375	335	12	model	model	NOUN
dti-1375	335	13	lack	lack	NOUN
dti-1375	335	14	tumor	tumor	NOUN
dti-1375	335	15	promoting	promote	VERB
dti-1375	335	16	factors	factor	NOUN
dti-1375	335	17	but	but	CCONJ
dti-1375	335	18	retained	retain	VERB
dti-1375	335	19	senescence	senescence	NOUN
dti-1375	335	20	activating	activate	VERB
dti-1375	335	21	factors	factor	NOUN
dti-1375	335	22	(	(	PUNCT
dti-1375	335	23	fig	fig	NOUN
dti-1375	335	24	.	.	PUNCT
dti-1375	336	1	7a	7a	NUM
dti-1375	336	2	)	)	PUNCT
dti-1375	336	3	.	.	PUNCT
dti-1375	337	1	discussion	discussion	NOUN
dti-1375	337	2	neuroblastoma	neuroblastoma	NOUN
dti-1375	337	3	has	have	AUX
dti-1375	337	4	been	be	AUX
dti-1375	337	5	considered	consider	VERB
dti-1375	337	6	as	as	ADP
dti-1375	337	7	a	a	DET
dti-1375	337	8	malignant	malignant	ADJ
dti-1375	337	9	manifestation	manifestation	NOUN
dti-1375	337	10	of	of	ADP
dti-1375	337	11	aberrant	aberrant	ADJ
dti-1375	337	12	sympathetic	sympathetic	ADJ
dti-1375	337	13	nervous	nervous	ADJ
dti-1375	337	14	system	system	NOUN
dti-1375	337	15	development	development	NOUN
dti-1375	337	16	.	.	PUNCT
dti-1375	338	1	irreconcilable	irreconcilable	ADJ
dti-1375	338	2	differences	difference	NOUN
dti-1375	338	3	in	in	ADP
dti-1375	338	4	therapeutic	therapeutic	ADJ
dti-1375	338	5	strategies	strategy	NOUN
dti-1375	338	6	due	due	ADJ
dti-1375	338	7	to	to	ADP
dti-1375	338	8	high	high	ADJ
dti-1375	338	9	tumor	tumor	NOUN
dti-1375	338	10	heterogeneity	heterogeneity	NOUN
dti-1375	338	11	limit	limit	VERB
dti-1375	338	12	existing	exist	VERB
dti-1375	338	13	approaches	approach	NOUN
dti-1375	338	14	,	,	PUNCT
dti-1375	338	15	thus	thus	ADV
dti-1375	338	16	,	,	PUNCT
dti-1375	338	17	insist	insist	VERB
dti-1375	338	18	on	on	ADP
dti-1375	338	19	developing	develop	VERB
dti-1375	338	20	novel	novel	ADJ
dti-1375	338	21	strategies	strategy	NOUN
dti-1375	338	22	,	,	PUNCT
dti-1375	338	23	which	which	PRON
dti-1375	338	24	can	can	AUX
dti-1375	338	25	exploit	exploit	VERB
dti-1375	338	26	the	the	DET
dti-1375	338	27	oncogenic	oncogenic	ADJ
dti-1375	338	28	signatures	signature	NOUN
dti-1375	338	29	of	of	ADP
dti-1375	338	30	tumor	tumor	NOUN
dti-1375	338	31	cells.36	cells.36	NOUN
dti-1375	338	32	earlier	early	ADV
dti-1375	338	33	,	,	PUNCT
dti-1375	338	34	we	we	PRON
dti-1375	338	35	showed	show	VERB
dti-1375	338	36	that	that	SCONJ
dti-1375	338	37	pharmacological	pharmacological	ADJ
dti-1375	338	38	targeting	targeting	NOUN
dti-1375	338	39	of	of	ADP
dti-1375	338	40	hsp90	hsp90	ADJ
dti-1375	338	41	functions	function	NOUN
dti-1375	338	42	deprives	deprive	VERB
dti-1375	338	43	proliferation	proliferation	NOUN
dti-1375	338	44	promoting	promote	VERB
dti-1375	338	45	signal	signal	NOUN
dti-1375	338	46	transduction	transduction	NOUN
dti-1375	338	47	in	in	ADP
dti-1375	338	48	imr-32	imr-32	ADV
dti-1375	338	49	neuroblastoma	neuroblastoma	NOUN
dti-1375	338	50	,	,	PUNCT
dti-1375	338	51	however	however	ADV
dti-1375	338	52	,	,	PUNCT
dti-1375	338	53	the	the	DET
dti-1375	338	54	apparent	apparent	ADJ
dti-1375	338	55	recurrence	recurrence	NOUN
dti-1375	338	56	on	on	ADP
dti-1375	338	57	post	post	ADJ
dti-1375	338	58	-	-	ADJ
dti-1375	338	59	treatment	treatment	NOUN
dti-1375	338	60	suggested	suggest	VERB
dti-1375	338	61	limitations	limitation	NOUN
dti-1375	338	62	to	to	ADP
dti-1375	338	63	this	this	PRON
dti-1375	338	64	approach.6,37	approach.6,37	PROPN
dti-1375	338	65	in	in	ADP
dti-1375	338	66	this	this	DET
dti-1375	338	67	study	study	NOUN
dti-1375	338	68	,	,	PUNCT
dti-1375	338	69	we	we	PRON
dti-1375	338	70	demonstrate	demonstrate	VERB
dti-1375	338	71	how	how	SCONJ
dti-1375	338	72	compromising	compromise	VERB
dti-1375	338	73	the	the	DET
dti-1375	338	74	chaperoning	chaperone	VERB
dti-1375	338	75	functions	function	NOUN
dti-1375	338	76	of	of	ADP
dti-1375	338	77	hsp90	hsp90	PROPN
dti-1375	338	78	(	(	PUNCT
dti-1375	338	79	17aag	17aag	ADJ
dti-1375	338	80	pre	pre	ADJ
dti-1375	338	81	-	-	NOUN
dti-1375	338	82	treatment	treatment	NOUN
dti-1375	338	83	)	)	PUNCT
dti-1375	338	84	sensitizes	sensitize	VERB
dti-1375	338	85	neuroblastoma	neuroblastoma	NOUN
dti-1375	338	86	to	to	ADP
dti-1375	338	87	doxorubicin	doxorubicin	PROPN
dti-1375	338	88	induced	induce	VERB
dti-1375	338	89	http://www.la-press.com	http://www.la-press.com	X
dti-1375	339	1	sarangi	sarangi	PROPN
dti-1375	339	2	et	et	PROPN
dti-1375	339	3	al	al	PROPN
dti-1375	339	4	32	32	NUM
dti-1375	339	5	drug	drug	NOUN
dti-1375	339	6	target	target	NOUN
dti-1375	339	7	insights	insight	NOUN
dti-1375	339	8	2012:6	2012:6	ADJ
dti-1375	339	9	cellular	cellular	ADJ
dti-1375	339	10	senescence	senescence	NOUN
dti-1375	339	11	,	,	PUNCT
dti-1375	339	12	and	and	CCONJ
dti-1375	339	13	present	present	ADJ
dti-1375	339	14	conformation	conformation	NOUN
dti-1375	339	15	specific	specific	ADJ
dti-1375	339	16	hsp90	hsp90	NOUN
dti-1375	339	17	as	as	ADP
dti-1375	339	18	a	a	DET
dti-1375	339	19	barrier	barrier	NOUN
dti-1375	339	20	to	to	ADP
dti-1375	339	21	enforced	enforce	VERB
dti-1375	339	22	senescence	senescence	NOUN
dti-1375	339	23	of	of	ADP
dti-1375	339	24	tumor	tumor	NOUN
dti-1375	339	25	cells	cell	NOUN
dti-1375	339	26	.	.	PUNCT
dti-1375	340	1	although	although	SCONJ
dti-1375	340	2	hsp90	hsp90	PROPN
dti-1375	340	3	is	be	AUX
dti-1375	340	4	an	an	DET
dti-1375	340	5	exciting	exciting	ADJ
dti-1375	340	6	drug	drug	NOUN
dti-1375	340	7	target	target	NOUN
dti-1375	340	8	due	due	ADP
dti-1375	340	9	to	to	ADP
dti-1375	340	10	its	its	PRON
dti-1375	340	11	cancer	cancer	NOUN
dti-1375	340	12	specificity	specificity	NOUN
dti-1375	340	13	it	it	PRON
dti-1375	340	14	is	be	AUX
dti-1375	340	15	likely	likely	ADJ
dti-1375	340	16	to	to	PART
dti-1375	340	17	induce	induce	VERB
dti-1375	340	18	drug	drug	NOUN
dti-1375	340	19	resistance	resistance	NOUN
dti-1375	340	20	over	over	ADP
dti-1375	340	21	time.38	time.38	NOUN
dti-1375	340	22	some	some	DET
dti-1375	340	23	hsp90	hsp90	ADJ
dti-1375	340	24	inhibitors	inhibitor	NOUN
dti-1375	340	25	can	can	AUX
dti-1375	340	26	induce	induce	VERB
dti-1375	340	27	oxidative	oxidative	ADJ
dti-1375	340	28	stress	stress	NOUN
dti-1375	340	29	leading	lead	VERB
dti-1375	340	30	to	to	ADP
dti-1375	340	31	non	non	ADJ
dti-1375	340	32	-	-	ADJ
dti-1375	340	33	specific	specific	ADJ
dti-1375	340	34	actions	action	NOUN
dti-1375	340	35	in	in	ADP
dti-1375	340	36	tumor	tumor	NOUN
dti-1375	340	37	cells	cell	NOUN
dti-1375	340	38	and	and	CCONJ
dti-1375	340	39	may	may	AUX
dti-1375	340	40	also	also	ADV
dti-1375	340	41	affect	affect	VERB
dti-1375	340	42	bystander	bystander	NOUN
dti-1375	340	43	cells.39	cells.39	NOUN
dti-1375	340	44	however	however	ADV
dti-1375	340	45	,	,	PUNCT
dti-1375	340	46	in	in	ADP
dti-1375	340	47	the	the	DET
dti-1375	340	48	present	present	ADJ
dti-1375	340	49	study	study	NOUN
dti-1375	340	50	,	,	PUNCT
dti-1375	340	51	microgram	microgram	ADJ
dti-1375	340	52	concentrations	concentration	NOUN
dti-1375	340	53	of	of	ADP
dti-1375	340	54	17aag	17aag	NOUN
dti-1375	340	55	for	for	ADP
dti-1375	340	56	prolonged	prolonged	ADJ
dti-1375	340	57	incubation	incubation	NOUN
dti-1375	340	58	periods	period	NOUN
dti-1375	340	59	is	be	AUX
dti-1375	340	60	required	require	VERB
dti-1375	340	61	to	to	PART
dti-1375	340	62	obtain	obtain	VERB
dti-1375	340	63	50	50	NUM
dti-1375	340	64	%	%	NOUN
dti-1375	340	65	cells	cell	NOUN
dti-1375	340	66	death	death	NOUN
dti-1375	340	67	,	,	PUNCT
dti-1375	340	68	which	which	PRON
dti-1375	340	69	may	may	AUX
dti-1375	340	70	develop	develop	VERB
dti-1375	340	71	drug	drug	NOUN
dti-1375	340	72	resistance	resistance	NOUN
dti-1375	340	73	in	in	ADP
dti-1375	340	74	cancer	cancer	NOUN
dti-1375	340	75	cells	cell	NOUN
dti-1375	340	76	in	in	ADP
dti-1375	340	77	due	due	ADJ
dti-1375	340	78	course	course	NOUN
dti-1375	340	79	of	of	ADP
dti-1375	340	80	time	time	NOUN
dti-1375	340	81	.	.	PUNCT
dti-1375	341	1	similar	similar	ADJ
dti-1375	341	2	findings	finding	NOUN
dti-1375	341	3	with	with	ADP
dti-1375	341	4	doxorubicin	doxorubicin	PROPN
dti-1375	341	5	suggested	suggest	VERB
dti-1375	341	6	ability	ability	NOUN
dti-1375	341	7	of	of	ADP
dti-1375	341	8	cells	cell	NOUN
dti-1375	341	9	to	to	PART
dti-1375	341	10	resist	resist	VERB
dti-1375	341	11	chemotherapeutic	chemotherapeutic	ADJ
dti-1375	341	12	intervention	intervention	NOUN
dti-1375	341	13	.	.	PUNCT
dti-1375	342	1	although	although	SCONJ
dti-1375	342	2	combination	combination	NOUN
dti-1375	342	3	drug	drug	NOUN
dti-1375	342	4	treatment	treatment	NOUN
dti-1375	342	5	has	have	AUX
dti-1375	342	6	improved	improve	VERB
dti-1375	342	7	the	the	DET
dti-1375	342	8	cytotoxic	cytotoxic	ADJ
dti-1375	342	9	effects	effect	NOUN
dti-1375	342	10	of	of	ADP
dti-1375	342	11	drugs	drug	NOUN
dti-1375	342	12	in	in	ADP
dti-1375	342	13	earlier	early	ADJ
dti-1375	342	14	time	time	NOUN
dti-1375	342	15	periods	period	NOUN
dti-1375	342	16	,	,	PUNCT
dti-1375	342	17	prolonged	prolonged	ADJ
dti-1375	342	18	periods	period	NOUN
dti-1375	342	19	of	of	ADP
dti-1375	342	20	incubation	incubation	NOUN
dti-1375	342	21	suggested	suggest	VERB
dti-1375	342	22	either	either	CCONJ
dti-1375	342	23	delayed	delay	VERB
dti-1375	342	24	drug	drug	NOUN
dti-1375	342	25	response	response	NOUN
dti-1375	342	26	or	or	CCONJ
dti-1375	342	27	acquired	acquire	VERB
dti-1375	342	28	drug	drug	NOUN
dti-1375	342	29	resistance	resistance	NOUN
dti-1375	342	30	(	(	PUNCT
dti-1375	342	31	supplemental	supplemental	ADJ
dti-1375	342	32	fig	fig	NOUN
dti-1375	342	33	.	.	PUNCT
dti-1375	343	1	1b	1b	NUM
dti-1375	343	2	)	)	PUNCT
dti-1375	343	3	.	.	PUNCT
dti-1375	344	1	doxorubicin	doxorubicin	PROPN
dti-1375	344	2	pre	pre	NOUN
dti-1375	344	3	-	-	NOUN
dti-1375	344	4	treatment	treatment	NOUN
dti-1375	344	5	followed	follow	VERB
dti-1375	344	6	by	by	ADP
dti-1375	344	7	17aag	17aag	NOUN
dti-1375	344	8	did	do	AUX
dti-1375	344	9	not	not	PART
dti-1375	344	10	improve	improve	VERB
dti-1375	344	11	efficacy	efficacy	NOUN
dti-1375	344	12	of	of	ADP
dti-1375	344	13	cytotoxic	cytotoxic	ADJ
dti-1375	344	14	treatment	treatment	NOUN
dti-1375	344	15	strategy	strategy	NOUN
dti-1375	344	16	,	,	PUNCT
dti-1375	344	17	but	but	CCONJ
dti-1375	344	18	17aagpretreatment	17aagpretreatment	NUM
dti-1375	344	19	has	have	AUX
dti-1375	344	20	significantly	significantly	ADV
dti-1375	344	21	decreased	decrease	VERB
dti-1375	344	22	cytotoxicity	cytotoxicity	NOUN
dti-1375	344	23	(	(	PUNCT
dti-1375	344	24	supplemental	supplemental	ADJ
dti-1375	344	25	fig	fig	NOUN
dti-1375	344	26	.	.	PUNCT
dti-1375	344	27	2b	2b	NUM
dti-1375	344	28	)	)	PUNCT
dti-1375	344	29	.	.	PUNCT
dti-1375	345	1	to	to	ADP
dti-1375	345	2	our	our	PRON
dti-1375	345	3	surprise	surprise	NOUN
dti-1375	345	4	,	,	PUNCT
dti-1375	345	5	sa	sa	PROPN
dti-1375	345	6	-	-	PUNCT
dti-1375	345	7	β	β	NOUN
dti-1375	345	8	-	-	ADJ
dti-1375	345	9	gal	gal	ADJ
dti-1375	345	10	staining	stain	VERB
dti-1375	345	11	indicative	indicative	ADJ
dti-1375	345	12	of	of	ADP
dti-1375	345	13	senescence	senescence	NOUN
dti-1375	345	14	was	be	AUX
dti-1375	345	15	observed	observe	VERB
dti-1375	345	16	in	in	ADP
dti-1375	345	17	17aag	17aag	ADJ
dti-1375	345	18	pre	pre	NOUN
dti-1375	345	19	-	-	NOUN
dti-1375	345	20	treatments	treatment	NOUN
dti-1375	345	21	suggesting	suggest	VERB
dti-1375	345	22	bypassing	bypass	VERB
dti-1375	345	23	chemotherapeutics	chemotherapeutic	NOUN
dti-1375	345	24	induced	induce	VERB
dti-1375	345	25	cytotoxicity	cytotoxicity	NOUN
dti-1375	345	26	results	result	NOUN
dti-1375	345	27	in	in	ADP
dti-1375	345	28	cellular	cellular	ADJ
dti-1375	345	29	senescence	senescence	NOUN
dti-1375	345	30	.	.	PUNCT
dti-1375	346	1	the	the	DET
dti-1375	346	2	increase	increase	NOUN
dti-1375	346	3	in	in	ADP
dti-1375	346	4	sa	sa	PROPN
dti-1375	346	5	-	-	PUNCT
dti-1375	346	6	β	β	NOUN
dti-1375	346	7	-	-	ADJ
dti-1375	346	8	gal	gal	ADJ
dti-1375	346	9	positive	positive	ADJ
dti-1375	346	10	cells	cell	NOUN
dti-1375	346	11	was	be	AUX
dti-1375	346	12	almost	almost	ADV
dti-1375	346	13	doubled	double	VERB
dti-1375	346	14	in	in	ADP
dti-1375	346	15	17aag	17aag	ADJ
dti-1375	346	16	pre	pre	NOUN
dti-1375	346	17	-	-	NOUN
dti-1375	346	18	sensitization	sensitization	NOUN
dti-1375	346	19	compared	compare	VERB
dti-1375	346	20	to	to	ADP
dti-1375	346	21	doxorubicin	doxorubicin	PROPN
dti-1375	346	22	treatment	treatment	NOUN
dti-1375	346	23	alone	alone	ADV
dti-1375	346	24	(	(	PUNCT
dti-1375	346	25	compare	compare	VERB
dti-1375	346	26	fig	fig	NOUN
dti-1375	346	27	.	.	PUNCT
dti-1375	347	1	1a1	1a1	NUM
dti-1375	347	2	with	with	ADP
dti-1375	347	3	fig	fig	NOUN
dti-1375	347	4	.	.	PUNCT
dti-1375	348	1	2a1	2a1	NUM
dti-1375	348	2	)	)	PUNCT
dti-1375	348	3	.	.	PUNCT
dti-1375	349	1	in	in	ADP
dti-1375	349	2	recent	recent	ADJ
dti-1375	349	3	years	year	NOUN
dti-1375	349	4	,	,	PUNCT
dti-1375	349	5	enforcing	enforce	VERB
dti-1375	349	6	premature	premature	ADJ
dti-1375	349	7	senescence	senescence	NOUN
dti-1375	349	8	in	in	ADP
dti-1375	349	9	tumor	tumor	NOUN
dti-1375	349	10	cells	cell	NOUN
dti-1375	349	11	with	with	ADP
dti-1375	349	12	chemotherapeutic	chemotherapeutic	ADJ
dti-1375	349	13	mediation	mediation	NOUN
dti-1375	349	14	has	have	AUX
dti-1375	349	15	been	be	AUX
dti-1375	349	16	proposed	propose	VERB
dti-1375	349	17	as	as	ADP
dti-1375	349	18	an	an	DET
dti-1375	349	19	alternate	alternate	ADJ
dti-1375	349	20	strategy	strategy	NOUN
dti-1375	349	21	to	to	PART
dti-1375	349	22	combat	combat	VERB
dti-1375	349	23	cancers.40,41	cancers.40,41	ADJ
dti-1375	349	24	prolonged	prolonged	ADJ
dti-1375	349	25	cytostasis	cytostasis	NOUN
dti-1375	349	26	either	either	CCONJ
dti-1375	349	27	through	through	ADP
dti-1375	349	28	p53	p53	NOUN
dti-1375	349	29	-	-	PUNCT
dti-1375	349	30	p21cip	p21cip	NOUN
dti-1375	349	31	/	/	SYM
dti-1375	349	32	waf-1	waf-1	ADP
dti-1375	349	33	or	or	CCONJ
dti-1375	349	34	prb	prb	ADV
dti-1375	349	35	-	-	PUNCT
dti-1375	349	36	p16ink4a	p16ink4a	NOUN
dti-1375	349	37	meditation	meditation	NOUN
dti-1375	349	38	was	be	AUX
dti-1375	349	39	thought	think	VERB
dti-1375	349	40	to	to	PART
dti-1375	349	41	be	be	AUX
dti-1375	349	42	the	the	DET
dti-1375	349	43	focal	focal	ADJ
dti-1375	349	44	point	point	NOUN
dti-1375	349	45	in	in	ADP
dti-1375	349	46	such	such	ADJ
dti-1375	349	47	models.42	models.42	NOUN
dti-1375	349	48	despite	despite	SCONJ
dti-1375	349	49	the	the	DET
dti-1375	349	50	fact	fact	NOUN
dti-1375	349	51	that	that	SCONJ
dti-1375	349	52	individual	individual	ADJ
dti-1375	349	53	drug	drug	NOUN
dti-1375	349	54	treatments	treatment	NOUN
dti-1375	349	55	do	do	AUX
dti-1375	349	56	not	not	PART
dti-1375	349	57	show	show	VERB
dti-1375	349	58	significant	significant	ADJ
dti-1375	349	59	increase	increase	NOUN
dti-1375	349	60	in	in	ADP
dti-1375	349	61	p21cip	p21cip	NOUN
dti-1375	349	62	/	/	SYM
dti-1375	349	63	waf-1	waf-1	ADP
dti-1375	349	64	expression	expression	NOUN
dti-1375	349	65	,	,	PUNCT
dti-1375	349	66	the	the	DET
dti-1375	349	67	combination	combination	NOUN
dti-1375	349	68	treatment	treatment	NOUN
dti-1375	349	69	showed	show	VERB
dti-1375	349	70	increased	increase	VERB
dti-1375	349	71	p21cip	p21cip	NOUN
dti-1375	349	72	/	/	SYM
dti-1375	349	73	waf-1	waf-1	ADP
dti-1375	349	74	expression	expression	NOUN
dti-1375	349	75	correlating	correlate	VERB
dti-1375	349	76	with	with	ADP
dti-1375	349	77	p53	p53	NOUN
dti-1375	349	78	(	(	PUNCT
dti-1375	349	79	compare	compare	VERB
dti-1375	349	80	fig	fig	NOUN
dti-1375	349	81	.	.	PUNCT
dti-1375	350	1	1b	1b	PROPN
dti-1375	350	2	and	and	CCONJ
dti-1375	350	3	c	c	X
dti-1375	350	4	with	with	ADP
dti-1375	350	5	fig	fig	NOUN
dti-1375	350	6	.	.	PUNCT
dti-1375	351	1	2d	2d	NOUN
dti-1375	351	2	and	and	CCONJ
dti-1375	351	3	e	e	X
dti-1375	351	4	)	)	PUNCT
dti-1375	351	5	that	that	PRON
dti-1375	351	6	however	however	ADV
dti-1375	351	7	,	,	PUNCT
dti-1375	351	8	did	do	AUX
dti-1375	351	9	not	not	PART
dti-1375	351	10	result	result	VERB
dti-1375	351	11	in	in	ADP
dti-1375	351	12	increased	increase	VERB
dti-1375	351	13	senescence	senescence	NOUN
dti-1375	351	14	positive	positive	ADJ
dti-1375	351	15	cells	cell	NOUN
dti-1375	351	16	(	(	PUNCT
dti-1375	351	17	compare	compare	VERB
dti-1375	351	18	fig	fig	NOUN
dti-1375	351	19	.	.	PUNCT
dti-1375	352	1	1a1	1a1	NUM
dti-1375	352	2	with	with	ADP
dti-1375	352	3	fig	fig	NOUN
dti-1375	352	4	.	.	PUNCT
dti-1375	353	1	2a1	2a1	NUM
dti-1375	353	2	)	)	PUNCT
dti-1375	353	3	.	.	PUNCT
dti-1375	354	1	the	the	DET
dti-1375	354	2	increased	increase	VERB
dti-1375	354	3	p21cip	p21cip	NOUN
dti-1375	354	4	/	/	SYM
dti-1375	354	5	waf-1	waf-1	NUM
dti-1375	354	6	expression	expression	NOUN
dti-1375	354	7	only	only	ADV
dti-1375	354	8	in	in	ADP
dti-1375	354	9	17aag	17aag	ADJ
dti-1375	354	10	pre	pre	NOUN
dti-1375	354	11	-	-	NOUN
dti-1375	354	12	treatment	treatment	NOUN
dti-1375	354	13	but	but	CCONJ
dti-1375	354	14	not	not	PART
dti-1375	354	15	in	in	ADP
dti-1375	354	16	doxorubicin	doxorubicin	PROPN
dti-1375	354	17	pre	pre	NOUN
dti-1375	354	18	-	-	NOUN
dti-1375	354	19	treatment	treatment	NOUN
dti-1375	354	20	resulted	result	VERB
dti-1375	354	21	in	in	ADP
dti-1375	354	22	increased	increase	VERB
dti-1375	354	23	senescence	senescence	NOUN
dti-1375	354	24	positive	positive	ADJ
dti-1375	354	25	cells	cell	NOUN
dti-1375	354	26	(	(	PUNCT
dti-1375	354	27	fig	fig	NOUN
dti-1375	354	28	.	.	PUNCT
dti-1375	355	1	2	2	NUM
dti-1375	355	2	)	)	PUNCT
dti-1375	355	3	.	.	PUNCT
dti-1375	356	1	although	although	SCONJ
dti-1375	356	2	,	,	PUNCT
dti-1375	356	3	replicative	replicative	ADJ
dti-1375	356	4	senescence	senescence	NOUN
dti-1375	356	5	is	be	AUX
dti-1375	356	6	linked	link	VERB
dti-1375	356	7	to	to	ADP
dti-1375	356	8	p16ink4a	p16ink4a	PROPN
dti-1375	356	9	,	,	PUNCT
dti-1375	356	10	in	in	ADP
dti-1375	356	11	our	our	PRON
dti-1375	356	12	study	study	NOUN
dti-1375	356	13	,	,	PUNCT
dti-1375	356	14	incessant	incessant	PROPN
dti-1375	356	15	p16ink4a	p16ink4a	NOUN
dti-1375	356	16	over	over	ADP
dti-1375	356	17	expression	expression	NOUN
dti-1375	356	18	was	be	AUX
dti-1375	356	19	found	find	VERB
dti-1375	356	20	to	to	PART
dti-1375	356	21	have	have	VERB
dti-1375	356	22	no	no	DET
dti-1375	356	23	influence	influence	NOUN
dti-1375	356	24	on	on	ADP
dti-1375	356	25	induced	induced	ADJ
dti-1375	356	26	senescence	senescence	NOUN
dti-1375	356	27	signaling	signal	VERB
dti-1375	356	28	in	in	ADP
dti-1375	356	29	individual	individual	ADJ
dti-1375	356	30	and	and	CCONJ
dti-1375	356	31	combination	combination	NOUN
dti-1375	356	32	drug	drug	NOUN
dti-1375	356	33	treatments	treatment	NOUN
dti-1375	356	34	(	(	PUNCT
dti-1375	356	35	fig	fig	NOUN
dti-1375	356	36	.	.	NOUN
dti-1375	357	1	1	1	NUM
dti-1375	357	2	)	)	PUNCT
dti-1375	357	3	,	,	PUNCT
dti-1375	357	4	but	but	CCONJ
dti-1375	357	5	its	its	PRON
dti-1375	357	6	decrease	decrease	NOUN
dti-1375	357	7	in	in	ADP
dti-1375	357	8	17aag	17aag	ADJ
dti-1375	357	9	pre	pre	NOUN
dti-1375	357	10	-	-	NOUN
dti-1375	357	11	treatment	treatment	NOUN
dti-1375	357	12	resulted	result	VERB
dti-1375	357	13	in	in	ADP
dti-1375	357	14	significant	significant	ADJ
dti-1375	357	15	increase	increase	NOUN
dti-1375	357	16	in	in	ADP
dti-1375	357	17	senescence	senescence	NOUN
dti-1375	357	18	positive	positive	ADJ
dti-1375	357	19	cells	cell	NOUN
dti-1375	357	20	(	(	PUNCT
dti-1375	357	21	fig	fig	NOUN
dti-1375	357	22	.	.	PUNCT
dti-1375	358	1	2	2	NUM
dti-1375	358	2	)	)	PUNCT
dti-1375	358	3	.	.	PUNCT
dti-1375	359	1	we	we	PRON
dti-1375	359	2	speculate	speculate	VERB
dti-1375	359	3	that	that	SCONJ
dti-1375	359	4	p16ink4a	p16ink4a	PROPN
dti-1375	359	5	may	may	AUX
dti-1375	359	6	be	be	AUX
dti-1375	359	7	antagonizing	antagonize	VERB
dti-1375	359	8	senescence	senescence	NOUN
dti-1375	359	9	signaling	signal	VERB
dti-1375	359	10	induced	induce	VERB
dti-1375	359	11	by	by	ADP
dti-1375	359	12	chemotherapeutic	chemotherapeutic	ADJ
dti-1375	359	13	interventions	intervention	NOUN
dti-1375	359	14	.	.	PUNCT
dti-1375	360	1	in	in	ADP
dti-1375	360	2	accordance	accordance	NOUN
dti-1375	360	3	with	with	ADP
dti-1375	360	4	this	this	PRON
dti-1375	360	5	,	,	PUNCT
dti-1375	360	6	p16ink4a	p16ink4a	PROPN
dti-1375	360	7	constitutive	constitutive	ADJ
dti-1375	360	8	expression22	expression22	NOUN
dti-1375	360	9	has	have	AUX
dti-1375	360	10	been	be	AUX
dti-1375	360	11	jurkat	jurkat	PROPN
dti-1375	360	12	control	control	PROPN
dti-1375	360	13	sa	sa	AUX
dti-1375	360	14	-	-	PUNCT
dti-1375	360	15	β	β	NOUN
dti-1375	360	16	-	-	ADJ
dti-1375	360	17	gal	gal	ADJ
dti-1375	360	18	cm	cm	PROPN
dti-1375	360	19	sa	sa	PROPN
dti-1375	360	20	-	-	PUNCT
dti-1375	360	21	β	β	NOUN
dti-1375	360	22	-	-	NOUN
dti-1375	360	23	gal	gal	NOUN
dti-1375	360	24	a	a	DET
dti-1375	360	25	b	b	NOUN
dti-1375	360	26	enforced	enforce	VERB
dti-1375	360	27	senescence	senescence	NOUN
dti-1375	360	28	17aag	17aag	NOUN
dti-1375	360	29	tumor	tumor	PROPN
dti-1375	360	30	phenotype	phenotype	NOUN
dti-1375	360	31	curcumin	curcumin	NOUN
dti-1375	360	32	egf	egf	PROPN
dti-1375	360	33	doxorubicin	doxorubicin	PROPN
dti-1375	360	34	mtor	mtor	PROPN
dti-1375	360	35	pi3k	pi3k	PROPN
dti-1375	360	36	senescence	senescence	NOUN
dti-1375	360	37	phenotype	phenotype	NOUN
dti-1375	360	38	immortal	immortal	ADJ
dti-1375	360	39	cellspre	cellspre	ADJ
dti-1375	360	40	-	-	ADJ
dti-1375	360	41	malignant	malignant	ADJ
dti-1375	360	42	cells	cell	NOUN
dti-1375	360	43	senescence	senescence	NOUN
dti-1375	360	44	phenotype	phenotype	NOUN
dti-1375	360	45	senescence	senescence	NOUN
dti-1375	360	46	phenotype	phenotype	NOUN
dti-1375	360	47	+	+	CCONJ
dti-1375	360	48	cell	cell	NOUN
dti-1375	360	49	death	death	NOUN
dti-1375	360	50	sasps	sasps	NOUN
dti-1375	360	51	sra01	sra01	NOUN
dti-1375	360	52	figure	figure	VERB
dti-1375	360	53	7	7	NUM
dti-1375	360	54	.	.	PUNCT
dti-1375	361	1	(	(	PUNCT
dti-1375	361	2	a	a	X
dti-1375	361	3	)	)	PUNCT
dti-1375	361	4	conditioned	condition	VERB
dti-1375	361	5	medium	medium	ADJ
dti-1375	361	6	induced	induced	ADJ
dti-1375	361	7	senescence	senescence	NOUN
dti-1375	361	8	activity	activity	NOUN
dti-1375	361	9	in	in	ADP
dti-1375	361	10	jurkat	jurkat	PROPN
dti-1375	361	11	and	and	CCONJ
dti-1375	361	12	sra01	sra01	NOUN
dti-1375	361	13	cells	cell	NOUN
dti-1375	361	14	.	.	PUNCT
dti-1375	362	1	the	the	DET
dti-1375	362	2	conditioned	condition	VERB
dti-1375	362	3	medium	medium	NOUN
dti-1375	362	4	from	from	ADP
dti-1375	362	5	17aag	17aag	ADJ
dti-1375	362	6	pre	pre	ADJ
dti-1375	362	7	-	-	ADJ
dti-1375	362	8	treatment	treatment	ADJ
dti-1375	362	9	accelerated	accelerated	ADJ
dti-1375	362	10	senescence	senescence	NOUN
dti-1375	362	11	cells	cell	NOUN
dti-1375	362	12	was	be	AUX
dti-1375	362	13	examined	examine	VERB
dti-1375	362	14	for	for	ADP
dti-1375	362	15	pro	pro	ADJ
dti-1375	362	16	-	-	ADJ
dti-1375	362	17	senescence	senescence	ADJ
dti-1375	362	18	activity	activity	NOUN
dti-1375	362	19	in	in	ADP
dti-1375	362	20	pre	pre	ADJ
dti-1375	362	21	-	-	ADJ
dti-1375	362	22	malignant	malignant	ADJ
dti-1375	362	23	(	(	PUNCT
dti-1375	362	24	jurkat	jurkat	PROPN
dti-1375	362	25	)	)	PUNCT
dti-1375	362	26	and	and	CCONJ
dti-1375	362	27	immortal	immortal	ADJ
dti-1375	362	28	cells	cell	NOUN
dti-1375	362	29	(	(	PUNCT
dti-1375	362	30	sra01	sra01	NOUN
dti-1375	362	31	)	)	PUNCT
dti-1375	362	32	for	for	ADP
dti-1375	362	33	6	6	NUM
dti-1375	362	34	-	-	PUNCT
dti-1375	362	35	days	day	NOUN
dti-1375	362	36	and	and	CCONJ
dti-1375	362	37	cells	cell	NOUN
dti-1375	362	38	were	be	AUX
dti-1375	362	39	stained	stain	VERB
dti-1375	362	40	for	for	ADP
dti-1375	362	41	sa	sa	NOUN
dti-1375	362	42	-	-	PUNCT
dti-1375	362	43	β	β	NOUN
dti-1375	362	44	-	-	ADJ
dti-1375	362	45	gal	gal	ADJ
dti-1375	362	46	activity	activity	NOUN
dti-1375	362	47	.	.	PUNCT
dti-1375	363	1	note	note	NOUN
dti-1375	363	2	decreased	decrease	VERB
dti-1375	363	3	number	number	NOUN
dti-1375	363	4	of	of	ADP
dti-1375	363	5	sa	sa	NOUN
dti-1375	363	6	-	-	ADJ
dti-1375	363	7	βgal	βgal	ADJ
dti-1375	363	8	positive	positive	ADJ
dti-1375	363	9	cells	cell	NOUN
dti-1375	363	10	in	in	ADP
dti-1375	363	11	sra01	sra01	NOUN
dti-1375	363	12	cells	cell	NOUN
dti-1375	363	13	compared	compare	VERB
dti-1375	363	14	to	to	ADP
dti-1375	363	15	jurkat	jurkat	PROPN
dti-1375	363	16	cells	cell	NOUN
dti-1375	363	17	.	.	PUNCT
dti-1375	364	1	(	(	PUNCT
dti-1375	364	2	b	b	X
dti-1375	364	3	)	)	PUNCT
dti-1375	364	4	proposed	propose	VERB
dti-1375	364	5	senescence	senescence	NOUN
dti-1375	364	6	activation	activation	NOUN
dti-1375	364	7	model	model	NOUN
dti-1375	364	8	.	.	PUNCT
dti-1375	365	1	http://www.la-press.com	http://www.la-press.com	X
dti-1375	366	1	hsp90	hsp90	ADJ
dti-1375	366	2	inhibition	inhibition	NOUN
dti-1375	366	3	accelerates	accelerate	VERB
dti-1375	366	4	senescence	senescence	NOUN
dti-1375	366	5	drug	drug	NOUN
dti-1375	366	6	target	target	NOUN
dti-1375	366	7	insights	insight	NOUN
dti-1375	366	8	2012:6	2012:6	NUM
dti-1375	366	9	33	33	NUM
dti-1375	366	10	implicated	implicate	VERB
dti-1375	366	11	in	in	ADP
dti-1375	366	12	bypassing	bypass	VERB
dti-1375	366	13	cellular	cellular	ADJ
dti-1375	366	14	senescence.43	senescence.43	NOUN
dti-1375	366	15	we	we	PRON
dti-1375	366	16	are	be	AUX
dti-1375	366	17	in	in	ADP
dti-1375	366	18	the	the	DET
dti-1375	366	19	process	process	NOUN
dti-1375	366	20	of	of	ADP
dti-1375	366	21	examining	examine	VERB
dti-1375	366	22	the	the	DET
dti-1375	366	23	role	role	NOUN
dti-1375	366	24	of	of	ADP
dti-1375	366	25	p16ink4a	p16ink4a	PROPN
dti-1375	366	26	in	in	ADP
dti-1375	366	27	tumor	tumor	NOUN
dti-1375	366	28	metastasis	metastasis	NOUN
dti-1375	366	29	and	and	CCONJ
dti-1375	366	30	bypassing	bypass	VERB
dti-1375	366	31	induced	induced	ADJ
dti-1375	366	32	senescence	senescence	NOUN
dti-1375	366	33	.	.	PUNCT
dti-1375	367	1	excluding	exclude	VERB
dti-1375	367	2	p16ink4a	p16ink4a	NOUN
dti-1375	367	3	in	in	ADP
dti-1375	367	4	17aag	17aag	ADJ
dti-1375	367	5	pre	pre	ADJ
dti-1375	367	6	-	-	ADJ
dti-1375	367	7	treatment	treatment	ADJ
dti-1375	367	8	induced	induced	ADJ
dti-1375	367	9	senescence	senescence	NOUN
dti-1375	367	10	,	,	PUNCT
dti-1375	367	11	the	the	DET
dti-1375	367	12	senescence	senescence	NOUN
dti-1375	367	13	observed	observe	VERB
dti-1375	367	14	in	in	ADP
dti-1375	367	15	our	our	PRON
dti-1375	367	16	model	model	NOUN
dti-1375	367	17	is	be	AUX
dti-1375	367	18	pragmatic	pragmatic	ADJ
dti-1375	367	19	to	to	ADP
dti-1375	367	20	p53	p53	NOUN
dti-1375	367	21	-	-	PUNCT
dti-1375	367	22	p21cip	p21cip	NOUN
dti-1375	367	23	/	/	SYM
dti-1375	367	24	waf-1	waf-1	ADP
dti-1375	367	25	mediation	mediation	NOUN
dti-1375	367	26	.	.	PUNCT
dti-1375	368	1	interestingly	interestingly	ADV
dti-1375	368	2	,	,	PUNCT
dti-1375	368	3	the	the	DET
dti-1375	368	4	stress	stress	NOUN
dti-1375	368	5	proteins	protein	NOUN
dti-1375	368	6	(	(	PUNCT
dti-1375	368	7	hsp27	hsp27	NOUN
dti-1375	368	8	,	,	PUNCT
dti-1375	368	9	hsp70	hsp70	NOUN
dti-1375	368	10	and	and	CCONJ
dti-1375	368	11	hsp90	hsp90	NOUN
dti-1375	368	12	)	)	PUNCT
dti-1375	368	13	that	that	PRON
dti-1375	368	14	showed	show	VERB
dti-1375	368	15	fluctuations	fluctuation	NOUN
dti-1375	368	16	in	in	ADP
dti-1375	368	17	individual	individual	ADJ
dti-1375	368	18	and	and	CCONJ
dti-1375	368	19	combination	combination	NOUN
dti-1375	368	20	drug	drug	NOUN
dti-1375	368	21	treatments	treatment	NOUN
dti-1375	368	22	(	(	PUNCT
dti-1375	368	23	fig	fig	NOUN
dti-1375	368	24	.	.	NOUN
dti-1375	368	25	1	1	NUM
dti-1375	368	26	)	)	PUNCT
dti-1375	368	27	were	be	AUX
dti-1375	368	28	not	not	PART
dti-1375	368	29	significantly	significantly	ADV
dti-1375	368	30	affected	affect	VERB
dti-1375	368	31	by	by	ADP
dti-1375	368	32	the	the	DET
dti-1375	368	33	followed	follow	VERB
dti-1375	368	34	drug	drug	NOUN
dti-1375	368	35	treatments	treatment	NOUN
dti-1375	368	36	(	(	PUNCT
dti-1375	368	37	fig	fig	NOUN
dti-1375	368	38	.	.	NOUN
dti-1375	369	1	2	2	X
dti-1375	369	2	)	)	PUNCT
dti-1375	369	3	implicating	implicate	VERB
dti-1375	369	4	functional	functional	ADJ
dti-1375	369	5	compromise	compromise	NOUN
dti-1375	369	6	but	but	CCONJ
dti-1375	369	7	not	not	PART
dti-1375	369	8	expression	expression	NOUN
dti-1375	369	9	levels	level	NOUN
dti-1375	369	10	play	play	VERB
dti-1375	369	11	role	role	NOUN
dti-1375	369	12	in	in	ADP
dti-1375	369	13	altering	alter	VERB
dti-1375	369	14	the	the	DET
dti-1375	369	15	cell	cell	NOUN
dti-1375	369	16	fate	fate	NOUN
dti-1375	369	17	.	.	PUNCT
dti-1375	370	1	consistent	consistent	ADJ
dti-1375	370	2	with	with	ADP
dti-1375	370	3	this	this	DET
dti-1375	370	4	stabilized	stabilize	VERB
dti-1375	370	5	p53	p53	NOUN
dti-1375	370	6	and	and	CCONJ
dti-1375	370	7	p21cip	p21cip	PROPN
dti-1375	370	8	/	/	SYM
dti-1375	370	9	waf-1	waf-1	ADP
dti-1375	370	10	levels	level	NOUN
dti-1375	370	11	appeared	appear	VERB
dti-1375	370	12	to	to	PART
dti-1375	370	13	play	play	VERB
dti-1375	370	14	significant	significant	ADJ
dti-1375	370	15	role	role	NOUN
dti-1375	370	16	in	in	ADP
dti-1375	370	17	cellular	cellular	ADJ
dti-1375	370	18	decision	decision	NOUN
dti-1375	370	19	correlating	correlate	VERB
dti-1375	370	20	with	with	ADP
dti-1375	370	21	differentially	differentially	ADV
dti-1375	370	22	regulated	regulate	VERB
dti-1375	370	23	cdks	cdks	NOUN
dti-1375	370	24	.	.	PUNCT
dti-1375	371	1	in	in	ADP
dti-1375	371	2	accordance	accordance	NOUN
dti-1375	371	3	with	with	ADP
dti-1375	371	4	this	this	PRON
dti-1375	371	5	we	we	PRON
dti-1375	371	6	did	do	AUX
dti-1375	371	7	not	not	PART
dti-1375	371	8	find	find	VERB
dti-1375	371	9	complete	complete	ADJ
dti-1375	371	10	loss	loss	NOUN
dti-1375	371	11	of	of	ADP
dti-1375	371	12	proliferation	proliferation	NOUN
dti-1375	371	13	(	(	PUNCT
dti-1375	371	14	pi3k	pi3k	NOUN
dti-1375	371	15	-	-	PUNCT
dti-1375	371	16	akt	akt	PROPN
dti-1375	371	17	)	)	PUNCT
dti-1375	371	18	or	or	CCONJ
dti-1375	371	19	survival	survival	NOUN
dti-1375	371	20	(	(	PUNCT
dti-1375	371	21	ras	ras	NOUN
dti-1375	371	22	-	-	ADJ
dti-1375	371	23	raf	raf	PROPN
dti-1375	371	24	-	-	PUNCT
dti-1375	371	25	erk	erk	NOUN
dti-1375	371	26	)	)	PUNCT
dti-1375	371	27	signal	signal	NOUN
dti-1375	371	28	transduction	transduction	NOUN
dti-1375	371	29	but	but	CCONJ
dti-1375	371	30	their	their	PRON
dti-1375	371	31	apparent	apparent	ADJ
dti-1375	371	32	alteration	alteration	NOUN
dti-1375	371	33	(	(	PUNCT
dti-1375	371	34	fig	fig	NOUN
dti-1375	371	35	.	.	NOUN
dti-1375	371	36	1	1	NUM
dti-1375	371	37	and	and	CCONJ
dti-1375	371	38	fig	fig	NOUN
dti-1375	371	39	.	.	PUNCT
dti-1375	371	40	2	2	NUM
dti-1375	371	41	)	)	PUNCT
dti-1375	371	42	.	.	PUNCT
dti-1375	372	1	the	the	DET
dti-1375	372	2	continued	continue	VERB
dti-1375	372	3	kinase	kinase	NOUN
dti-1375	372	4	activities	activity	NOUN
dti-1375	372	5	may	may	AUX
dti-1375	372	6	therefore	therefore	ADV
dti-1375	372	7	relate	relate	VERB
dti-1375	372	8	to	to	ADP
dti-1375	372	9	cellular	cellular	ADJ
dti-1375	372	10	crisis	crisis	NOUN
dti-1375	372	11	induced	induce	VERB
dti-1375	372	12	by	by	ADP
dti-1375	372	13	the	the	DET
dti-1375	372	14	combination	combination	NOUN
dti-1375	372	15	drug	drug	NOUN
dti-1375	372	16	treatments	treatment	NOUN
dti-1375	372	17	.	.	PUNCT
dti-1375	373	1	the	the	DET
dti-1375	373	2	data	datum	NOUN
dti-1375	373	3	obtained	obtain	VERB
dti-1375	373	4	from	from	ADP
dti-1375	373	5	figures	figure	NOUN
dti-1375	373	6	1	1	NUM
dti-1375	373	7	and	and	CCONJ
dti-1375	373	8	2	2	NUM
dti-1375	373	9	however	however	ADV
dti-1375	373	10	failed	fail	VERB
dti-1375	373	11	to	to	PART
dti-1375	373	12	conform	conform	VERB
dti-1375	373	13	to	to	ADP
dti-1375	373	14	any	any	DET
dti-1375	373	15	classical	classical	ADJ
dti-1375	373	16	signal	signal	NOUN
dti-1375	373	17	transduction	transduction	NOUN
dti-1375	373	18	pathway	pathway	NOUN
dti-1375	373	19	leading	lead	VERB
dti-1375	373	20	to	to	ADP
dti-1375	373	21	senescence	senescence	NOUN
dti-1375	373	22	,	,	PUNCT
dti-1375	373	23	it	it	PRON
dti-1375	373	24	confirmed	confirm	VERB
dti-1375	373	25	that	that	SCONJ
dti-1375	373	26	senescence	senescence	NOUN
dti-1375	373	27	occurred	occur	VERB
dti-1375	373	28	through	through	ADP
dti-1375	373	29	p53	p53	NOUN
dti-1375	373	30	-	-	PUNCT
dti-1375	373	31	p21cip/	p21cip/	NOUN
dti-1375	373	32	waf-1	waf-1	ADP
dti-1375	373	33	mediation	mediation	NOUN
dti-1375	373	34	.	.	PUNCT
dti-1375	374	1	with	with	ADP
dti-1375	374	2	this	this	DET
dti-1375	374	3	lead	lead	NOUN
dti-1375	374	4	we	we	PRON
dti-1375	374	5	went	go	VERB
dti-1375	374	6	ahead	ahead	ADV
dti-1375	374	7	for	for	ADP
dti-1375	374	8	further	further	ADJ
dti-1375	374	9	characterization	characterization	NOUN
dti-1375	374	10	of	of	ADP
dti-1375	374	11	senescence	senescence	NOUN
dti-1375	374	12	.	.	PUNCT
dti-1375	375	1	enhanced	enhance	VERB
dti-1375	375	2	sahf	sahf	NOUN
dti-1375	375	3	is	be	AUX
dti-1375	375	4	involved	involve	VERB
dti-1375	375	5	in	in	ADP
dti-1375	375	6	maintaining	maintain	VERB
dti-1375	375	7	the	the	DET
dti-1375	375	8	senescence	senescence	NOUN
dti-1375	375	9	phenotype	phenotype	NOUN
dti-1375	375	10	.	.	PUNCT
dti-1375	376	1	although	although	SCONJ
dti-1375	376	2	sa	sa	PROPN
dti-1375	376	3	-	-	PUNCT
dti-1375	376	4	β	β	NOUN
dti-1375	376	5	-	-	ADJ
dti-1375	376	6	gal	gal	ADJ
dti-1375	376	7	staining	staining	NOUN
dti-1375	376	8	can	can	AUX
dti-1375	376	9	be	be	AUX
dti-1375	376	10	used	use	VERB
dti-1375	376	11	to	to	PART
dti-1375	376	12	detect	detect	VERB
dti-1375	376	13	both	both	DET
dti-1375	376	14	cellular	cellular	ADJ
dti-1375	376	15	stress	stress	NOUN
dti-1375	376	16	response	response	NOUN
dti-1375	376	17	as	as	ADV
dti-1375	376	18	well	well	ADV
dti-1375	376	19	as	as	ADP
dti-1375	376	20	senescence	senescence	NOUN
dti-1375	376	21	response	response	NOUN
dti-1375	376	22	,	,	PUNCT
dti-1375	376	23	increased	increase	VERB
dti-1375	376	24	sa	sa	PROPN
dti-1375	376	25	-	-	PUNCT
dti-1375	376	26	β	β	NOUN
dti-1375	376	27	-	-	ADJ
dti-1375	376	28	gal	gal	ADJ
dti-1375	376	29	staining	stain	VERB
dti-1375	376	30	with	with	ADP
dti-1375	376	31	increased	increase	VERB
dti-1375	376	32	nucleus	nucleus	NOUN
dti-1375	376	33	to	to	PART
dti-1375	376	34	cytoplasm	cytoplasm	NOUN
dti-1375	376	35	ratio	ratio	NOUN
dti-1375	376	36	indicated	indicate	VERB
dti-1375	376	37	the	the	DET
dti-1375	376	38	onset	onset	NOUN
dti-1375	376	39	of	of	ADP
dti-1375	376	40	senescence	senescence	NOUN
dti-1375	376	41	(	(	PUNCT
dti-1375	376	42	supplemental	supplemental	ADJ
dti-1375	376	43	figs	fig	NOUN
dti-1375	376	44	.	.	PUNCT
dti-1375	377	1	1a	1a	NOUN
dti-1375	377	2	and	and	CCONJ
dti-1375	377	3	2a	2a	NUM
dti-1375	377	4	)	)	PUNCT
dti-1375	377	5	,	,	PUNCT
dti-1375	377	6	which	which	PRON
dti-1375	377	7	further	far	ADV
dti-1375	377	8	correlated	correlate	VERB
dti-1375	377	9	with	with	ADP
dti-1375	377	10	a	a	DET
dti-1375	377	11	time	time	NOUN
dti-1375	377	12	dependent	dependent	ADJ
dti-1375	377	13	increase	increase	NOUN
dti-1375	377	14	in	in	ADP
dti-1375	377	15	sahf	sahf	NOUN
dti-1375	377	16	staining	stain	VERB
dti-1375	377	17	(	(	PUNCT
dti-1375	377	18	fig	fig	NOUN
dti-1375	377	19	.	.	PUNCT
dti-1375	378	1	3d	3d	NUM
dti-1375	378	2	)	)	PUNCT
dti-1375	378	3	.	.	PUNCT
dti-1375	379	1	our	our	PRON
dti-1375	379	2	results	result	NOUN
dti-1375	379	3	may	may	AUX
dti-1375	379	4	differ	differ	VERB
dti-1375	379	5	with	with	ADP
dti-1375	379	6	the	the	DET
dti-1375	379	7	findings	finding	NOUN
dti-1375	379	8	of	of	ADP
dti-1375	379	9	restall	restall	NOUN
dti-1375	379	10	and	and	CCONJ
dti-1375	379	11	lorimer,44	lorimer,44	NOUN
dti-1375	379	12	who	who	PRON
dti-1375	379	13	reported	report	VERB
dti-1375	379	14	that	that	SCONJ
dti-1375	379	15	hsp90	hsp90	ADJ
dti-1375	379	16	inhibition	inhibition	NOUN
dti-1375	379	17	alone	alone	ADV
dti-1375	379	18	can	can	AUX
dti-1375	379	19	induce	induce	VERB
dti-1375	379	20	premature	premature	ADJ
dti-1375	379	21	senescence	senescence	NOUN
dti-1375	379	22	in	in	ADP
dti-1375	379	23	small	small	ADJ
dti-1375	379	24	cell	cell	NOUN
dti-1375	379	25	lung	lung	NOUN
dti-1375	379	26	carcinoma	carcinoma	NOUN
dti-1375	379	27	(	(	PUNCT
dti-1375	379	28	sclc	sclc	PROPN
dti-1375	379	29	)	)	PUNCT
dti-1375	379	30	.	.	PUNCT
dti-1375	380	1	the	the	DET
dti-1375	380	2	sahf	sahf	NOUN
dti-1375	380	3	increase	increase	NOUN
dti-1375	380	4	in	in	ADP
dti-1375	380	5	their	their	PRON
dti-1375	380	6	study	study	NOUN
dti-1375	380	7	has	have	AUX
dti-1375	380	8	been	be	AUX
dti-1375	380	9	correlated	correlate	VERB
dti-1375	380	10	to	to	ADP
dti-1375	380	11	senescence	senescence	NOUN
dti-1375	380	12	associated	associate	VERB
dti-1375	380	13	with	with	ADP
dti-1375	380	14	ddr	ddr	NOUN
dti-1375	380	15	response	response	NOUN
dti-1375	380	16	to	to	ADP
dti-1375	380	17	dna	dna	PROPN
dti-1375	380	18	damage	damage	NOUN
dti-1375	380	19	.	.	PUNCT
dti-1375	381	1	studies	study	NOUN
dti-1375	381	2	from	from	ADP
dti-1375	381	3	different	different	ADJ
dti-1375	381	4	groups	group	NOUN
dti-1375	381	5	indicate	indicate	VERB
dti-1375	381	6	that	that	SCONJ
dti-1375	381	7	hsp90	hsp90	ADJ
dti-1375	381	8	inhibition	inhibition	NOUN
dti-1375	381	9	per	per	ADP
dti-1375	381	10	se	se	X
dti-1375	381	11	will	will	AUX
dti-1375	381	12	not	not	PART
dti-1375	381	13	induce	induce	VERB
dti-1375	381	14	dna	dna	NOUN
dti-1375	381	15	damage	damage	NOUN
dti-1375	381	16	but	but	CCONJ
dti-1375	381	17	compromises	compromise	VERB
dti-1375	381	18	ddr.45,46	ddr.45,46	NOUN
dti-1375	381	19	we	we	PRON
dti-1375	381	20	bring	bring	VERB
dti-1375	381	21	forth	forth	ADP
dti-1375	381	22	evidence	evidence	NOUN
dti-1375	381	23	from	from	ADP
dti-1375	381	24	the	the	DET
dti-1375	381	25	present	present	ADJ
dti-1375	381	26	study	study	NOUN
dti-1375	381	27	that	that	SCONJ
dti-1375	381	28	compromising	compromise	VERB
dti-1375	381	29	the	the	DET
dti-1375	381	30	chaperoning	chaperone	VERB
dti-1375	381	31	functions	function	NOUN
dti-1375	381	32	of	of	ADP
dti-1375	381	33	hsp90	hsp90	NOUN
dti-1375	381	34	with	with	ADP
dti-1375	381	35	17aag	17aag	NOUN
dti-1375	381	36	enhances	enhance	NOUN
dti-1375	381	37	the	the	DET
dti-1375	381	38	doxorubicin	doxorubicin	PROPN
dti-1375	381	39	induced	induce	VERB
dti-1375	381	40	ddr	ddr	NOUN
dti-1375	381	41	in	in	ADP
dti-1375	381	42	neuroblastoma	neuroblastoma	NOUN
dti-1375	381	43	.	.	PUNCT
dti-1375	382	1	another	another	DET
dti-1375	382	2	marker	marker	NOUN
dti-1375	382	3	of	of	ADP
dti-1375	382	4	senescence	senescence	NOUN
dti-1375	382	5	,	,	PUNCT
dti-1375	382	6	h3k4me3	h3k4me3	PROPN
dti-1375	382	7	suggests	suggest	VERB
dti-1375	382	8	increased	increase	VERB
dti-1375	382	9	patterns	pattern	NOUN
dti-1375	382	10	of	of	ADP
dti-1375	382	11	histone	histone	NOUN
dti-1375	382	12	acetylation	acetylation	NOUN
dti-1375	382	13	and	and	CCONJ
dti-1375	382	14	competence	competence	NOUN
dti-1375	382	15	of	of	ADP
dti-1375	382	16	transcriptional	transcriptional	ADJ
dti-1375	382	17	activation47	activation47	NOUN
dti-1375	382	18	thus	thus	ADV
dti-1375	382	19	negates	negate	VERB
dti-1375	382	20	sahfs	sahfs	NOUN
dti-1375	382	21	.	.	PUNCT
dti-1375	383	1	however	however	ADV
dti-1375	383	2	,	,	PUNCT
dti-1375	383	3	in	in	ADP
dti-1375	383	4	the	the	DET
dti-1375	383	5	present	present	ADJ
dti-1375	383	6	model	model	NOUN
dti-1375	383	7	,	,	PUNCT
dti-1375	383	8	h3k4me3	h3k4me3	PROPN
dti-1375	383	9	cytoplasmic	cytoplasmic	ADJ
dti-1375	383	10	accumulation	accumulation	NOUN
dti-1375	383	11	has	have	AUX
dti-1375	383	12	invalidated	invalidate	VERB
dti-1375	383	13	its	its	PRON
dti-1375	383	14	role	role	NOUN
dti-1375	383	15	in	in	ADP
dti-1375	383	16	active	active	ADJ
dti-1375	383	17	chromatin	chromatin	NOUN
dti-1375	383	18	transcription	transcription	NOUN
dti-1375	383	19	.	.	PUNCT
dti-1375	384	1	nevertheless	nevertheless	ADV
dti-1375	384	2	,	,	PUNCT
dti-1375	384	3	f	f	X
dti-1375	384	4	-	-	PUNCT
dti-1375	384	5	actin	actin	VERB
dti-1375	384	6	re	re	NOUN
dti-1375	384	7	-	-	NOUN
dti-1375	384	8	organization	organization	NOUN
dti-1375	384	9	and	and	CCONJ
dti-1375	384	10	increased	increase	VERB
dti-1375	384	11	cell	cell	NOUN
dti-1375	384	12	granularity	granularity	NOUN
dti-1375	384	13	together	together	ADV
dti-1375	384	14	with	with	ADP
dti-1375	384	15	non	non	ADJ
dti-1375	384	16	-	-	ADJ
dti-1375	384	17	functional	functional	ADJ
dti-1375	384	18	telomerases	telomerase	NOUN
dti-1375	384	19	has	have	AUX
dti-1375	384	20	appraised	appraise	VERB
dti-1375	384	21	telomerase	telomerase	NOUN
dti-1375	384	22	-	-	PUNCT
dti-1375	384	23	independent	independent	ADJ
dti-1375	384	24	senescence	senescence	NOUN
dti-1375	384	25	activation	activation	NOUN
dti-1375	384	26	(	(	PUNCT
dti-1375	384	27	fig	fig	NOUN
dti-1375	384	28	.	.	PUNCT
dti-1375	385	1	3	3	NUM
dti-1375	385	2	)	)	PUNCT
dti-1375	385	3	.	.	PUNCT
dti-1375	386	1	physiological	physiological	ADJ
dti-1375	386	2	factors	factor	NOUN
dti-1375	386	3	such	such	ADJ
dti-1375	386	4	as	as	ADP
dti-1375	386	5	ros	ros	PROPN
dti-1375	386	6	and	and	CCONJ
dti-1375	386	7	ca2	ca2	PROPN
dti-1375	386	8	+	+	PROPN
dti-1375	386	9	were	be	AUX
dti-1375	386	10	also	also	ADV
dti-1375	386	11	implicated	implicate	VERB
dti-1375	386	12	in	in	ADP
dti-1375	386	13	senescence	senescence	NOUN
dti-1375	386	14	signaling	signaling	NOUN
dti-1375	386	15	.	.	PUNCT
dti-1375	387	1	in	in	ADP
dti-1375	387	2	fact	fact	NOUN
dti-1375	387	3	aging	age	VERB
dti-1375	387	4	phenotypes	phenotype	NOUN
dti-1375	387	5	were	be	AUX
dti-1375	387	6	thought	think	VERB
dti-1375	387	7	to	to	PART
dti-1375	387	8	be	be	AUX
dti-1375	387	9	established	establish	VERB
dti-1375	387	10	through	through	ADP
dti-1375	387	11	oxidative	oxidative	ADJ
dti-1375	387	12	signaling	signaling	NOUN
dti-1375	387	13	.	.	PUNCT
dti-1375	388	1	since	since	SCONJ
dti-1375	388	2	hsp90	hsp90	ADJ
dti-1375	388	3	inhibitors	inhibitor	NOUN
dti-1375	388	4	alone	alone	ADV
dti-1375	388	5	can	can	AUX
dti-1375	388	6	elevate	elevate	VERB
dti-1375	388	7	ros,39	ros,39	NOUN
dti-1375	388	8	in	in	ADP
dti-1375	388	9	the	the	DET
dti-1375	388	10	present	present	ADJ
dti-1375	388	11	study	study	NOUN
dti-1375	388	12	,	,	PUNCT
dti-1375	388	13	the	the	DET
dti-1375	388	14	ros	ros	PROPN
dti-1375	388	15	mediated	mediate	VERB
dti-1375	388	16	senescence	senescence	NOUN
dti-1375	388	17	activation48,49	activation48,49	VERB
dti-1375	388	18	can	can	AUX
dti-1375	388	19	not	not	PART
dti-1375	388	20	be	be	AUX
dti-1375	388	21	exempted	exempt	VERB
dti-1375	388	22	.	.	PUNCT
dti-1375	389	1	to	to	ADP
dti-1375	389	2	our	our	PRON
dti-1375	389	3	surprise	surprise	NOUN
dti-1375	389	4	,	,	PUNCT
dti-1375	389	5	we	we	PRON
dti-1375	389	6	observed	observe	VERB
dti-1375	389	7	only	only	ADV
dti-1375	389	8	a	a	DET
dti-1375	389	9	small	small	ADJ
dti-1375	389	10	but	but	CCONJ
dti-1375	389	11	gradual	gradual	ADJ
dti-1375	389	12	increase	increase	NOUN
dti-1375	389	13	in	in	ADP
dti-1375	389	14	ros	ros	PROPN
dti-1375	389	15	levels	level	NOUN
dti-1375	389	16	,	,	PUNCT
dti-1375	389	17	which	which	PRON
dti-1375	389	18	were	be	AUX
dti-1375	389	19	addressed	address	VERB
dti-1375	389	20	by	by	ADP
dti-1375	389	21	the	the	DET
dti-1375	389	22	activated	activate	VERB
dti-1375	389	23	mitochondrial	mitochondrial	ADJ
dti-1375	389	24	antioxidant	antioxidant	ADJ
dti-1375	389	25	defense	defense	NOUN
dti-1375	389	26	.	.	PUNCT
dti-1375	390	1	these	these	DET
dti-1375	390	2	findings	finding	NOUN
dti-1375	390	3	sets	set	VERB
dti-1375	390	4	aside	aside	ADP
dti-1375	390	5	the	the	DET
dti-1375	390	6	role	role	NOUN
dti-1375	390	7	of	of	ADP
dti-1375	390	8	ros	ros	PROPN
dti-1375	390	9	in	in	ADP
dti-1375	390	10	senescence	senescence	NOUN
dti-1375	390	11	activation.27,50,51	activation.27,50,51	PROPN
dti-1375	390	12	although	although	SCONJ
dti-1375	390	13	hsp90	hsp90	ADJ
dti-1375	390	14	inhibition	inhibition	NOUN
dti-1375	390	15	induces	induce	VERB
dti-1375	390	16	the	the	DET
dti-1375	390	17	release	release	NOUN
dti-1375	390	18	of	of	ADP
dti-1375	390	19	intracellular	intracellular	ADJ
dti-1375	390	20	ca2+,52	ca2+,52	PRON
dti-1375	390	21	in	in	ADP
dti-1375	390	22	a	a	DET
dti-1375	390	23	rat	rat	NOUN
dti-1375	390	24	tumor	tumor	NOUN
dti-1375	390	25	model	model	NOUN
dti-1375	390	26	,	,	PUNCT
dti-1375	390	27	this	this	DET
dti-1375	390	28	release	release	NOUN
dti-1375	390	29	was	be	AUX
dti-1375	390	30	then	then	ADV
dti-1375	390	31	correlated	correlate	VERB
dti-1375	390	32	to	to	ADP
dti-1375	390	33	decreased	decrease	VERB
dti-1375	390	34	functions	function	NOUN
dti-1375	390	35	of	of	ADP
dti-1375	390	36	hsps.53	hsps.53	NOUN
dti-1375	390	37	unlike	unlike	ADP
dti-1375	390	38	the	the	DET
dti-1375	390	39	rat	rat	NOUN
dti-1375	390	40	model	model	NOUN
dti-1375	390	41	where	where	SCONJ
dti-1375	390	42	hsp	hsp	NOUN
dti-1375	390	43	gene	gene	NOUN
dti-1375	390	44	transcription	transcription	NOUN
dti-1375	390	45	was	be	AUX
dti-1375	390	46	found	find	VERB
dti-1375	390	47	to	to	PART
dti-1375	390	48	be	be	AUX
dti-1375	390	49	compromised	compromise	VERB
dti-1375	390	50	,	,	PUNCT
dti-1375	390	51	imr-32	imr-32	SCONJ
dti-1375	390	52	cells	cell	NOUN
dti-1375	390	53	retained	retain	VERB
dti-1375	390	54	some	some	DET
dti-1375	390	55	hsps	hsps	PROPN
dti-1375	390	56	suggesting	suggest	VERB
dti-1375	390	57	survival	survival	NOUN
dti-1375	390	58	potential	potential	NOUN
dti-1375	390	59	of	of	ADP
dti-1375	390	60	cells	cell	NOUN
dti-1375	390	61	upon	upon	SCONJ
dti-1375	390	62	elevated	elevated	ADJ
dti-1375	390	63	ca2	ca2	PROPN
dti-1375	390	64	+	+	PROPN
dti-1375	390	65	levels	level	NOUN
dti-1375	390	66	.	.	PUNCT
dti-1375	391	1	reinforcing	reinforce	VERB
dti-1375	391	2	this	this	PRON
dti-1375	391	3	,	,	PUNCT
dti-1375	391	4	the	the	DET
dti-1375	391	5	increased	increase	VERB
dti-1375	391	6	calcium	calcium	NOUN
dti-1375	391	7	levels	level	NOUN
dti-1375	391	8	correlated	correlate	VERB
dti-1375	391	9	with	with	ADP
dti-1375	391	10	the	the	DET
dti-1375	391	11	activation	activation	NOUN
dti-1375	391	12	of	of	ADP
dti-1375	391	13	senescence	senescence	NOUN
dti-1375	391	14	response	response	NOUN
dti-1375	391	15	but	but	CCONJ
dti-1375	391	16	not	not	PART
dti-1375	391	17	apoptosis	apoptosis	NOUN
dti-1375	391	18	(	(	PUNCT
dti-1375	391	19	fig	fig	NOUN
dti-1375	391	20	.	.	PUNCT
dti-1375	392	1	4	4	NUM
dti-1375	392	2	)	)	PUNCT
dti-1375	392	3	.	.	PUNCT
dti-1375	393	1	in	in	ADP
dti-1375	393	2	previous	previous	ADJ
dti-1375	393	3	sections	section	NOUN
dti-1375	393	4	we	we	PRON
dti-1375	393	5	discussed	discuss	VERB
dti-1375	393	6	how	how	SCONJ
dti-1375	393	7	senescent	senescent	ADJ
dti-1375	393	8	cells	cell	NOUN
dti-1375	393	9	are	be	AUX
dti-1375	393	10	resistant	resistant	ADJ
dti-1375	393	11	to	to	ADP
dti-1375	393	12	cell	cell	NOUN
dti-1375	393	13	death	death	NOUN
dti-1375	393	14	mechanisms	mechanism	NOUN
dti-1375	393	15	such	such	ADJ
dti-1375	393	16	as	as	ADP
dti-1375	393	17	apoptosis	apoptosis	NOUN
dti-1375	393	18	under	under	ADP
dti-1375	393	19	conditions	condition	NOUN
dti-1375	393	20	of	of	ADP
dti-1375	393	21	depleted	depleted	ADJ
dti-1375	393	22	oxygen	oxygen	NOUN
dti-1375	393	23	stress54	stress54	NOUN
dti-1375	393	24	and	and	CCONJ
dti-1375	393	25	now	now	ADV
dti-1375	393	26	in	in	ADP
dti-1375	393	27	agreement	agreement	NOUN
dti-1375	393	28	with	with	ADP
dti-1375	393	29	this	this	PRON
dti-1375	393	30	,	,	PUNCT
dti-1375	393	31	in	in	ADP
dti-1375	393	32	the	the	DET
dti-1375	393	33	present	present	ADJ
dti-1375	393	34	study	study	NOUN
dti-1375	393	35	,	,	PUNCT
dti-1375	393	36	we	we	PRON
dti-1375	393	37	observed	observe	VERB
dti-1375	393	38	activation	activation	NOUN
dti-1375	393	39	of	of	ADP
dti-1375	393	40	autophagy	autophagy	NOUN
dti-1375	393	41	,	,	PUNCT
dti-1375	393	42	which	which	PRON
dti-1375	393	43	was	be	AUX
dti-1375	393	44	considered	consider	VERB
dti-1375	393	45	to	to	PART
dti-1375	393	46	be	be	AUX
dti-1375	393	47	pro	pro	ADJ
dti-1375	393	48	-	-	ADJ
dti-1375	393	49	survival	survival	ADJ
dti-1375	393	50	response	response	NOUN
dti-1375	393	51	mechanism	mechanism	NOUN
dti-1375	393	52	.	.	PUNCT
dti-1375	394	1	senescence	senescence	NOUN
dti-1375	394	2	mediated	mediate	VERB
dti-1375	394	3	by	by	ADP
dti-1375	394	4	p53	p53	NOUN
dti-1375	394	5	-	-	PUNCT
dti-1375	394	6	p21cip	p21cip	NOUN
dti-1375	394	7	/	/	SYM
dti-1375	394	8	waf-1	waf-1	NUM
dti-1375	394	9	has	have	AUX
dti-1375	394	10	been	be	AUX
dti-1375	394	11	reported	report	VERB
dti-1375	394	12	to	to	PART
dti-1375	394	13	be	be	AUX
dti-1375	394	14	reversible	reversible	ADJ
dti-1375	394	15	therefore	therefore	ADV
dti-1375	394	16	may	may	AUX
dti-1375	394	17	limit	limit	VERB
dti-1375	394	18	the	the	DET
dti-1375	394	19	application	application	NOUN
dti-1375	394	20	of	of	ADP
dti-1375	394	21	our	our	PRON
dti-1375	394	22	strategy	strategy	NOUN
dti-1375	394	23	.	.	PUNCT
dti-1375	395	1	failing	fail	VERB
dti-1375	395	2	to	to	PART
dti-1375	395	3	induce	induce	VERB
dti-1375	395	4	senescence	senescence	NOUN
dti-1375	395	5	reversal	reversal	NOUN
dti-1375	395	6	with	with	ADP
dti-1375	395	7	mtor	mtor	PROPN
dti-1375	395	8	inhibitor	inhibitor	PROPN
dti-1375	395	9	,	,	PUNCT
dti-1375	395	10	egf	egf	PROPN
dti-1375	395	11	or	or	CCONJ
dti-1375	395	12	curcumin	curcumin	NOUN
dti-1375	395	13	that	that	PRON
dti-1375	395	14	were	be	AUX
dti-1375	395	15	known	know	VERB
dti-1375	395	16	to	to	PART
dti-1375	395	17	decelerates	decelerate	VERB
dti-1375	395	18	senescence,55,56	senescence,55,56	PROPN
dti-1375	395	19	appraise	appraise	NOUN
dti-1375	395	20	that	that	PRON
dti-1375	395	21	enforced	enforce	VERB
dti-1375	395	22	proliferation	proliferation	NOUN
dti-1375	395	23	stimulus	stimulus	NOUN
dti-1375	395	24	is	be	AUX
dti-1375	395	25	inoperative	inoperative	ADJ
dti-1375	395	26	once	once	SCONJ
dti-1375	395	27	senescence	senescence	NOUN
dti-1375	395	28	signal	signal	NOUN
dti-1375	395	29	is	be	AUX
dti-1375	395	30	being	be	AUX
dti-1375	395	31	activated	activate	VERB
dti-1375	395	32	.	.	PUNCT
dti-1375	396	1	in	in	ADP
dti-1375	396	2	accordance	accordance	NOUN
dti-1375	396	3	with	with	ADP
dti-1375	396	4	earlier	early	ADJ
dti-1375	396	5	understanding	understanding	NOUN
dti-1375	396	6	that	that	SCONJ
dti-1375	396	7	synergistic	synergistic	ADJ
dti-1375	396	8	activation	activation	NOUN
dti-1375	396	9	of	of	ADP
dti-1375	396	10	pi3k	pi3k	PROPN
dti-1375	396	11	and	and	CCONJ
dti-1375	396	12	mtor	mtor	PROPN
dti-1375	396	13	provide	provide	VERB
dti-1375	396	14	survival	survival	NOUN
dti-1375	396	15	fitness	fitness	PROPN
dti-1375	396	16	to	to	ADP
dti-1375	396	17	cancer	cancer	NOUN
dti-1375	396	18	cells,57	cells,57	NOUN
dti-1375	396	19	and	and	CCONJ
dti-1375	396	20	their	their	PRON
dti-1375	396	21	chronic	chronic	ADJ
dti-1375	396	22	activation	activation	NOUN
dti-1375	396	23	lead	lead	VERB
dti-1375	396	24	to	to	ADP
dti-1375	396	25	senescence,58	senescence,58	NOUN
dti-1375	396	26	we	we	PRON
dti-1375	396	27	demonstrated	demonstrate	VERB
dti-1375	396	28	that	that	SCONJ
dti-1375	396	29	drug	drug	NOUN
dti-1375	396	30	treatments	treatment	NOUN
dti-1375	396	31	promote	promote	VERB
dti-1375	396	32	senescence	senescence	NOUN
dti-1375	396	33	through	through	ADP
dti-1375	396	34	chronic	chronic	ADJ
dti-1375	396	35	signal	signal	NOUN
dti-1375	396	36	activation	activation	NOUN
dti-1375	396	37	(	(	PUNCT
dti-1375	396	38	fig	fig	NOUN
dti-1375	396	39	.	.	PUNCT
dti-1375	396	40	5	5	NUM
dti-1375	396	41	)	)	PUNCT
dti-1375	396	42	.	.	PUNCT
dti-1375	397	1	therefore	therefore	ADV
dti-1375	397	2	the	the	DET
dti-1375	397	3	irreversible	irreversible	ADJ
dti-1375	397	4	potential	potential	NOUN
dti-1375	397	5	of	of	ADP
dti-1375	397	6	tumor	tumor	NOUN
dti-1375	397	7	cells	cell	NOUN
dti-1375	397	8	may	may	AUX
dti-1375	397	9	relate	relate	VERB
dti-1375	397	10	to	to	ADP
dti-1375	397	11	enhanced	enhanced	ADJ
dti-1375	397	12	senescence	senescence	NOUN
dti-1375	397	13	associated	associate	VERB
dti-1375	397	14	multi	multi	ADJ
dti-1375	397	15	drug	drug	NOUN
dti-1375	397	16	resistance.59	resistance.59	VERB
dti-1375	397	17	doxorubicin	doxorubicin	PROPN
dti-1375	397	18	being	be	AUX
dti-1375	397	19	http://www.la-press.com	http://www.la-press.com	X
dti-1375	397	20	sarangi	sarangi	PROPN
dti-1375	397	21	et	et	PROPN
dti-1375	397	22	al	al	PROPN
dti-1375	397	23	34	34	NUM
dti-1375	397	24	drug	drug	NOUN
dti-1375	397	25	target	target	NOUN
dti-1375	397	26	insights	insight	NOUN
dti-1375	397	27	2012:6	2012:6	NUM
dti-1375	397	28	the	the	DET
dti-1375	397	29	substrate	substrate	NOUN
dti-1375	397	30	of	of	ADP
dti-1375	397	31	multi	multi	ADJ
dti-1375	397	32	drug	drug	NOUN
dti-1375	397	33	resistance	resistance	NOUN
dti-1375	397	34	gene	gene	NOUN
dti-1375	397	35	product	product	NOUN
dti-1375	397	36	,	,	PUNCT
dti-1375	397	37	mdr1,60	mdr1,60	PROPN
dti-1375	397	38	it	it	PRON
dti-1375	397	39	was	be	AUX
dti-1375	397	40	presumed	presume	VERB
dti-1375	397	41	that	that	SCONJ
dti-1375	397	42	hsp90	hsp90	ADJ
dti-1375	397	43	inhibition	inhibition	NOUN
dti-1375	397	44	promotes	promote	VERB
dti-1375	397	45	its	its	PRON
dti-1375	397	46	bioavailability	bioavailability	NOUN
dti-1375	397	47	to	to	PART
dti-1375	397	48	exhibit	exhibit	VERB
dti-1375	397	49	enhanced	enhanced	ADJ
dti-1375	397	50	senescence	senescence	NOUN
dti-1375	397	51	activity	activity	NOUN
dti-1375	397	52	.	.	PUNCT
dti-1375	398	1	with	with	ADP
dti-1375	398	2	the	the	DET
dti-1375	398	3	prelude	prelude	NOUN
dti-1375	398	4	that	that	PRON
dti-1375	398	5	hsps	hsps	PROPN
dti-1375	398	6	promote	promote	VERB
dti-1375	398	7	multidrug	multidrug	VERB
dti-1375	398	8	resistance	resistance	NOUN
dti-1375	398	9	in	in	ADP
dti-1375	398	10	tumor	tumor	NOUN
dti-1375	398	11	cells	cell	NOUN
dti-1375	398	12	,	,	PUNCT
dti-1375	398	13	we	we	PRON
dti-1375	398	14	interpret	interpret	VERB
dti-1375	398	15	that	that	DET
dti-1375	398	16	functional	functional	ADJ
dti-1375	398	17	hsp90	hsp90	ADJ
dti-1375	398	18	inhibition	inhibition	NOUN
dti-1375	398	19	in	in	ADP
dti-1375	398	20	mdr1	mdr1	PROPN
dti-1375	398	21	positive9	positive9	PROPN
dti-1375	398	22	imr-32	imr-32	SCONJ
dti-1375	398	23	cells	cell	NOUN
dti-1375	398	24	could	could	AUX
dti-1375	398	25	possibly	possibly	ADV
dti-1375	398	26	have	have	AUX
dti-1375	398	27	primarily	primarily	ADV
dti-1375	398	28	compromised	compromise	VERB
dti-1375	398	29	the	the	DET
dti-1375	398	30	drug	drug	NOUN
dti-1375	398	31	efflux	efflux	NOUN
dti-1375	398	32	,	,	PUNCT
dti-1375	398	33	thus	thus	ADV
dti-1375	398	34	could	could	AUX
dti-1375	398	35	have	have	AUX
dti-1375	398	36	increased	increase	VERB
dti-1375	398	37	doxorubicin	doxorubicin	PROPN
dti-1375	398	38	cellular	cellular	ADJ
dti-1375	398	39	accumulation	accumulation	NOUN
dti-1375	398	40	to	to	PART
dti-1375	398	41	promote	promote	VERB
dti-1375	398	42	senescence	senescence	NOUN
dti-1375	398	43	associated	associate	VERB
dti-1375	398	44	effects	effect	NOUN
dti-1375	398	45	.	.	PUNCT
dti-1375	399	1	the	the	DET
dti-1375	399	2	augmentation	augmentation	NOUN
dti-1375	399	3	of	of	ADP
dti-1375	399	4	doxorubicin	doxorubicin	PROPN
dti-1375	399	5	induced	induce	VERB
dti-1375	399	6	senescence	senescence	NOUN
dti-1375	399	7	by	by	ADP
dti-1375	399	8	hsp90	hsp90	ADJ
dti-1375	399	9	inhibitors	inhibitor	NOUN
dti-1375	399	10	in	in	ADP
dti-1375	399	11	neuroblastoma	neuroblastoma	NOUN
dti-1375	399	12	suggests	suggest	VERB
dti-1375	399	13	an	an	DET
dti-1375	399	14	alternate	alternate	ADJ
dti-1375	399	15	strategy	strategy	NOUN
dti-1375	399	16	to	to	PART
dti-1375	399	17	combat	combat	VERB
dti-1375	399	18	cancers	cancer	NOUN
dti-1375	399	19	.	.	PUNCT
dti-1375	400	1	evaluation	evaluation	NOUN
dti-1375	400	2	whether	whether	SCONJ
dti-1375	400	3	enforced	enforce	VERB
dti-1375	400	4	cellular	cellular	ADJ
dti-1375	400	5	senescence	senescence	NOUN
dti-1375	400	6	act	act	NOUN
dti-1375	400	7	as	as	ADP
dti-1375	400	8	a	a	DET
dti-1375	400	9	tumor	tumor	NOUN
dti-1375	400	10	suppression	suppression	NOUN
dti-1375	400	11	mechanism	mechanism	NOUN
dti-1375	400	12	by	by	ADP
dti-1375	400	13	anchorage	anchorage	PROPN
dti-1375	400	14	independent	independent	ADJ
dti-1375	400	15	(	(	PUNCT
dti-1375	400	16	growth	growth	NOUN
dti-1375	400	17	on	on	ADP
dti-1375	400	18	agarose	agarose	NOUN
dti-1375	400	19	)	)	PUNCT
dti-1375	400	20	and	and	CCONJ
dti-1375	400	21	anchorage	anchorage	PROPN
dti-1375	400	22	dependent	dependent	ADJ
dti-1375	400	23	(	(	PUNCT
dti-1375	400	24	growth	growth	NOUN
dti-1375	400	25	on	on	ADP
dti-1375	400	26	matrigel	matrigel	NOUN
dti-1375	400	27	)	)	PUNCT
dti-1375	400	28	growth	growth	NOUN
dti-1375	400	29	assays	assay	NOUN
dti-1375	400	30	revealed	reveal	VERB
dti-1375	400	31	anti	anti	ADJ
dti-1375	400	32	-	-	ADJ
dti-1375	400	33	proliferative	proliferative	ADJ
dti-1375	400	34	and	and	CCONJ
dti-1375	400	35	anti	anti	ADJ
dti-1375	400	36	-	-	ADJ
dti-1375	400	37	angiogenic	angiogenic	ADJ
dti-1375	400	38	competence	competence	NOUN
dti-1375	400	39	.	.	PUNCT
dti-1375	401	1	however	however	ADV
dti-1375	401	2	,	,	PUNCT
dti-1375	401	3	in	in	ADP
dti-1375	401	4	contrast	contrast	NOUN
dti-1375	401	5	to	to	ADP
dti-1375	401	6	compromising	compromise	VERB
dti-1375	401	7	of	of	ADP
dti-1375	401	8	hsp90	hsp90	ADJ
dti-1375	401	9	chaperoning	chaperone	VERB
dti-1375	401	10	function	function	NOUN
dti-1375	401	11	using	use	VERB
dti-1375	401	12	pharmacological	pharmacological	ADJ
dti-1375	401	13	drugs	drug	NOUN
dti-1375	401	14	,	,	PUNCT
dti-1375	401	15	knockdown	knockdown	NOUN
dti-1375	401	16	of	of	ADP
dti-1375	401	17	hsp90	hsp90	PROPN
dti-1375	401	18	using	use	VERB
dti-1375	401	19	sirna	sirna	PROPN
dti-1375	401	20	has	have	AUX
dti-1375	401	21	significantly	significantly	ADV
dti-1375	401	22	compromised	compromise	VERB
dti-1375	401	23	the	the	DET
dti-1375	401	24	survival	survival	NOUN
dti-1375	401	25	potential	potential	NOUN
dti-1375	401	26	of	of	ADP
dti-1375	401	27	senescent	senescent	ADJ
dti-1375	401	28	population	population	NOUN
dti-1375	401	29	(	(	PUNCT
dti-1375	401	30	fig	fig	NOUN
dti-1375	401	31	.	.	PUNCT
dti-1375	402	1	6	6	X
dti-1375	402	2	)	)	PUNCT
dti-1375	402	3	suggesting	suggest	VERB
dti-1375	402	4	hsp90	hsp90	ADJ
dti-1375	402	5	expression	expression	NOUN
dti-1375	402	6	is	be	AUX
dti-1375	402	7	indispensible	indispensible	ADJ
dti-1375	402	8	for	for	ADP
dti-1375	402	9	cell	cell	NOUN
dti-1375	402	10	survival	survival	NOUN
dti-1375	402	11	whether	whether	SCONJ
dti-1375	402	12	cells	cell	NOUN
dti-1375	402	13	are	be	AUX
dti-1375	402	14	from	from	ADP
dti-1375	402	15	normal	normal	ADJ
dti-1375	402	16	,	,	PUNCT
dti-1375	402	17	tumor	tumor	NOUN
dti-1375	402	18	or	or	CCONJ
dti-1375	402	19	senescent	senescent	ADJ
dti-1375	402	20	groups	group	NOUN
dti-1375	402	21	.	.	PUNCT
dti-1375	403	1	paradoxically	paradoxically	ADV
dti-1375	403	2	chemotherapeutic	chemotherapeutic	ADJ
dti-1375	403	3	drugs	drug	NOUN
dti-1375	403	4	must	must	AUX
dti-1375	403	5	exert	exert	VERB
dti-1375	403	6	two	two	NUM
dti-1375	403	7	important	important	ADJ
dti-1375	403	8	tumor	tumor	NOUN
dti-1375	403	9	suppressor	suppressor	NOUN
dti-1375	403	10	mechanisms	mechanism	NOUN
dti-1375	403	11	namely	namely	ADV
dti-1375	403	12	,	,	PUNCT
dti-1375	403	13	senescence	senescence	NOUN
dti-1375	403	14	or	or	CCONJ
dti-1375	403	15	apoptosis	apoptosis	NOUN
dti-1375	403	16	.	.	PUNCT
dti-1375	404	1	hsps	hsps	PROPN
dti-1375	404	2	antagonize	antagonize	VERB
dti-1375	404	3	apoptotic	apoptotic	ADJ
dti-1375	404	4	signaling1,53	signaling1,53	NOUN
dti-1375	404	5	but	but	CCONJ
dti-1375	404	6	facilitates	facilitate	VERB
dti-1375	404	7	senescence.61	senescence.61	NOUN
dti-1375	404	8	the	the	DET
dti-1375	404	9	conformational	conformational	ADJ
dti-1375	404	10	maturation	maturation	NOUN
dti-1375	404	11	and	and	CCONJ
dti-1375	404	12	functional	functional	ADJ
dti-1375	404	13	stabilization	stabilization	NOUN
dti-1375	404	14	of	of	ADP
dti-1375	404	15	oncogenes	oncogene	NOUN
dti-1375	404	16	was	be	AUX
dti-1375	404	17	aided	aid	VERB
dti-1375	404	18	by	by	ADP
dti-1375	404	19	conformation	conformation	NOUN
dti-1375	404	20	specific	specific	ADJ
dti-1375	404	21	hsp90	hsp90	PROPN
dti-1375	404	22	(	(	PUNCT
dti-1375	404	23	high	high	ADJ
dti-1375	404	24	affinity	affinity	NOUN
dti-1375	404	25	conformation	conformation	NOUN
dti-1375	404	26	)	)	PUNCT
dti-1375	404	27	present	present	ADJ
dti-1375	404	28	in	in	ADP
dti-1375	404	29	tumor	tumor	NOUN
dti-1375	404	30	cells	cell	NOUN
dti-1375	404	31	,	,	PUNCT
dti-1375	404	32	which	which	PRON
dti-1375	404	33	is	be	AUX
dti-1375	404	34	in	in	ADP
dti-1375	404	35	addition	addition	NOUN
dti-1375	404	36	to	to	ADP
dti-1375	404	37	the	the	DET
dti-1375	404	38	presence	presence	NOUN
dti-1375	404	39	of	of	ADP
dti-1375	404	40	normal	normal	ADJ
dti-1375	404	41	hsp90	hsp90	PROPN
dti-1375	404	42	(	(	PUNCT
dti-1375	404	43	low	low	ADJ
dti-1375	404	44	affinity	affinity	NOUN
dti-1375	404	45	conformation).32	conformation).32	VERB
dti-1375	404	46	in	in	ADP
dti-1375	404	47	the	the	DET
dti-1375	404	48	present	present	ADJ
dti-1375	404	49	study	study	NOUN
dti-1375	404	50	,	,	PUNCT
dti-1375	404	51	pre	pre	NOUN
dti-1375	404	52	-	-	NOUN
dti-1375	404	53	sensitization	sensitization	NOUN
dti-1375	404	54	of	of	ADP
dti-1375	404	55	tumor	tumor	NOUN
dti-1375	404	56	cells	cell	NOUN
dti-1375	404	57	with	with	ADP
dti-1375	404	58	conformation	conformation	NOUN
dti-1375	404	59	specific	specific	ADJ
dti-1375	404	60	anti	anti	ADJ
dti-1375	404	61	-	-	ADJ
dti-1375	404	62	hsp90	hsp90	ADJ
dti-1375	404	63	inhibitor	inhibitor	NOUN
dti-1375	404	64	,	,	PUNCT
dti-1375	404	65	17aag	17aag	NOUN
dti-1375	404	66	to	to	PART
dti-1375	404	67	doxorubicin	doxorubicin	PROPN
dti-1375	404	68	treatment	treatment	NOUN
dti-1375	404	69	suggested	suggest	VERB
dti-1375	404	70	that	that	SCONJ
dti-1375	404	71	by	by	ADP
dti-1375	404	72	compromising	compromise	VERB
dti-1375	404	73	high	high	ADJ
dti-1375	404	74	affinity	affinity	NOUN
dti-1375	404	75	conformation	conformation	NOUN
dti-1375	404	76	of	of	ADP
dti-1375	404	77	hsp90	hsp90	PROPN
dti-1375	404	78	it	it	PRON
dti-1375	404	79	may	may	AUX
dti-1375	404	80	be	be	AUX
dti-1375	404	81	possible	possible	ADJ
dti-1375	404	82	to	to	PART
dti-1375	404	83	sensitize	sensitize	VERB
dti-1375	404	84	hsp90	hsp90	ADJ
dti-1375	404	85	inhibition	inhibition	NOUN
dti-1375	404	86	resistant	resistant	ADJ
dti-1375	404	87	tumor	tumor	NOUN
dti-1375	404	88	cells	cell	NOUN
dti-1375	404	89	to	to	ADP
dti-1375	404	90	chemotherapeutic	chemotherapeutic	ADJ
dti-1375	404	91	intervention	intervention	NOUN
dti-1375	404	92	.	.	PUNCT
dti-1375	405	1	our	our	PRON
dti-1375	405	2	results	result	NOUN
dti-1375	405	3	demonstrate	demonstrate	VERB
dti-1375	405	4	that	that	SCONJ
dti-1375	405	5	hsp90	hsp90	VERB
dti-1375	405	6	in	in	ADP
dti-1375	405	7	its	its	PRON
dti-1375	405	8	high	high	ADJ
dti-1375	405	9	affinity	affinity	NOUN
dti-1375	405	10	conformation	conformation	NOUN
dti-1375	405	11	undeniably	undeniably	ADV
dti-1375	405	12	acts	act	VERB
dti-1375	405	13	as	as	ADP
dti-1375	405	14	an	an	DET
dti-1375	405	15	impediment	impediment	NOUN
dti-1375	405	16	to	to	ADP
dti-1375	405	17	senescence	senescence	NOUN
dti-1375	405	18	signaling	signal	VERB
dti-1375	405	19	due	due	ADP
dti-1375	405	20	to	to	ADP
dti-1375	405	21	its	its	PRON
dti-1375	405	22	involvement	involvement	NOUN
dti-1375	405	23	in	in	ADP
dti-1375	405	24	tumor	tumor	NOUN
dti-1375	405	25	progression	progression	NOUN
dti-1375	405	26	.	.	PUNCT
dti-1375	406	1	our	our	PRON
dti-1375	406	2	findings	finding	NOUN
dti-1375	406	3	are	be	AUX
dti-1375	406	4	in	in	ADP
dti-1375	406	5	agreement	agreement	NOUN
dti-1375	406	6	with	with	ADP
dti-1375	406	7	earlier	early	ADJ
dti-1375	406	8	hypothesis	hypothesis	NOUN
dti-1375	406	9	that	that	PRON
dti-1375	406	10	decreased	decrease	VERB
dti-1375	406	11	chaperoning	chaperone	VERB
dti-1375	406	12	functions	function	NOUN
dti-1375	406	13	of	of	ADP
dti-1375	406	14	hsps	hsps	PROPN
dti-1375	406	15	promote	promote	VERB
dti-1375	406	16	senescence	senescence	NOUN
dti-1375	406	17	signaling.62,63	signaling.62,63	NOUN
dti-1375	406	18	findings	finding	NOUN
dti-1375	406	19	from	from	ADP
dti-1375	406	20	campici	campici	PROPN
dti-1375	406	21	’s	’s	PART
dti-1375	406	22	group64	group64	NOUN
dti-1375	406	23	though	though	SCONJ
dti-1375	406	24	projected	project	VERB
dti-1375	406	25	enforced	enforce	VERB
dti-1375	406	26	cellular	cellular	ADJ
dti-1375	406	27	senescence	senescence	NOUN
dti-1375	406	28	as	as	ADP
dti-1375	406	29	a	a	DET
dti-1375	406	30	tumor	tumor	NOUN
dti-1375	406	31	suppressor	suppressor	NOUN
dti-1375	406	32	mechanism	mechanism	NOUN
dti-1375	406	33	,	,	PUNCT
dti-1375	406	34	later	later	ADV
dti-1375	406	35	findings	finding	NOUN
dti-1375	406	36	from	from	ADP
dti-1375	406	37	the	the	DET
dti-1375	406	38	same	same	ADJ
dti-1375	406	39	group	group	NOUN
dti-1375	406	40	showed	show	VERB
dti-1375	406	41	that	that	SCONJ
dti-1375	406	42	factors	factor	NOUN
dti-1375	406	43	secreted	secrete	VERB
dti-1375	406	44	to	to	ADP
dti-1375	406	45	the	the	DET
dti-1375	406	46	culture	culture	NOUN
dti-1375	406	47	medium	medium	NOUN
dti-1375	406	48	(	(	PUNCT
dti-1375	406	49	condition	condition	NOUN
dti-1375	406	50	medium	medium	ADJ
dti-1375	406	51	-	-	PUNCT
dti-1375	406	52	cm	cm	NOUN
dti-1375	406	53	)	)	PUNCT
dti-1375	406	54	by	by	ADP
dti-1375	406	55	senescent	senescent	ADJ
dti-1375	406	56	cells	cell	NOUN
dti-1375	406	57	(	(	PUNCT
dti-1375	406	58	sasps	sasps	NOUN
dti-1375	406	59	)	)	PUNCT
dti-1375	406	60	can	can	AUX
dti-1375	406	61	promote	promote	VERB
dti-1375	406	62	transformation	transformation	NOUN
dti-1375	406	63	in	in	ADP
dti-1375	406	64	premalignant	premalignant	ADJ
dti-1375	406	65	cells.34,65	cells.34,65	NOUN
dti-1375	406	66	these	these	DET
dti-1375	406	67	findings	finding	NOUN
dti-1375	406	68	invalidated	invalidate	VERB
dti-1375	406	69	the	the	DET
dti-1375	406	70	strategy	strategy	NOUN
dti-1375	406	71	of	of	ADP
dti-1375	406	72	enforced	enforce	VERB
dti-1375	406	73	cellular	cellular	ADJ
dti-1375	406	74	senescence	senescence	NOUN
dti-1375	406	75	for	for	ADP
dti-1375	406	76	antitumor	antitumor	PROPN
dti-1375	406	77	treatment.66	treatment.66	NOUN
dti-1375	406	78	nevertheless	nevertheless	ADV
dti-1375	406	79	,	,	PUNCT
dti-1375	406	80	we	we	PRON
dti-1375	406	81	project	project	VERB
dti-1375	406	82	that	that	SCONJ
dti-1375	406	83	cm	cm	NOUN
dti-1375	406	84	from	from	ADP
dti-1375	406	85	17aag	17aag	ADJ
dti-1375	406	86	pre	pre	ADJ
dti-1375	406	87	-	-	ADJ
dti-1375	406	88	treatment	treatment	ADJ
dti-1375	406	89	induced	induced	ADJ
dti-1375	406	90	senescent	senescent	ADJ
dti-1375	406	91	cells	cell	NOUN
dti-1375	406	92	lack	lack	VERB
dti-1375	406	93	proliferation	proliferation	NOUN
dti-1375	406	94	stimulus	stimulus	NOUN
dti-1375	406	95	as	as	SCONJ
dti-1375	406	96	envisioned	envision	VERB
dti-1375	406	97	by	by	ADP
dti-1375	406	98	other	other	ADJ
dti-1375	406	99	groups	group	NOUN
dti-1375	406	100	but	but	CCONJ
dti-1375	406	101	interestingly	interestingly	ADV
dti-1375	406	102	accelerated	accelerate	VERB
dti-1375	406	103	senescence	senescence	NOUN
dti-1375	406	104	-	-	PUNCT
dti-1375	406	105	like	like	ADJ
dti-1375	406	106	phenotype	phenotype	NOUN
dti-1375	406	107	in	in	ADP
dti-1375	406	108	target	target	NOUN
dti-1375	406	109	cells	cell	NOUN
dti-1375	406	110	(	(	PUNCT
dti-1375	406	111	fig	fig	NOUN
dti-1375	406	112	.	.	PUNCT
dti-1375	407	1	7a	7a	NUM
dti-1375	407	2	)	)	PUNCT
dti-1375	407	3	.	.	PUNCT
dti-1375	408	1	the	the	DET
dti-1375	408	2	disparity	disparity	NOUN
dti-1375	408	3	in	in	ADP
dti-1375	408	4	sasps	sasps	NOUN
dti-1375	408	5	from	from	ADP
dti-1375	408	6	others	other	NOUN
dti-1375	408	7	to	to	ADP
dti-1375	408	8	our	our	PRON
dti-1375	408	9	study	study	NOUN
dti-1375	408	10	was	be	AUX
dti-1375	408	11	found	find	VERB
dti-1375	408	12	to	to	PART
dti-1375	408	13	be	be	AUX
dti-1375	408	14	only	only	ADV
dti-1375	408	15	the	the	DET
dti-1375	408	16	use	use	NOUN
dti-1375	408	17	of	of	ADP
dti-1375	408	18	hsp90	hsp90	ADJ
dti-1375	408	19	inhibition	inhibition	NOUN
dti-1375	408	20	to	to	PART
dti-1375	408	21	accelerate	accelerate	VERB
dti-1375	408	22	senescence	senescence	NOUN
dti-1375	408	23	.	.	PUNCT
dti-1375	409	1	our	our	PRON
dti-1375	409	2	findings	finding	NOUN
dti-1375	409	3	,	,	PUNCT
dti-1375	409	4	therefore	therefore	ADV
dti-1375	409	5	,	,	PUNCT
dti-1375	409	6	may	may	AUX
dti-1375	409	7	have	have	VERB
dti-1375	409	8	clinical	clinical	ADJ
dti-1375	409	9	benefits	benefit	NOUN
dti-1375	409	10	for	for	ADP
dti-1375	409	11	cutting	cut	VERB
dti-1375	409	12	-	-	PUNCT
dti-1375	409	13	edge	edge	NOUN
dti-1375	409	14	treatments	treatment	NOUN
dti-1375	409	15	using	use	VERB
dti-1375	409	16	anti	anti	ADJ
dti-1375	409	17	-	-	ADJ
dti-1375	409	18	hsp90	hsp90	ADJ
dti-1375	409	19	drugs	drug	NOUN
dti-1375	409	20	.	.	PUNCT
dti-1375	410	1	for	for	ADP
dti-1375	410	2	thorough	thorough	ADJ
dti-1375	410	3	understanding	understanding	NOUN
dti-1375	410	4	of	of	ADP
dti-1375	410	5	the	the	DET
dti-1375	410	6	molecular	molecular	ADJ
dti-1375	410	7	cross	cross	NOUN
dti-1375	410	8	-	-	NOUN
dti-1375	410	9	talk	talk	NOUN
dti-1375	410	10	in	in	ADP
dti-1375	410	11	neuroblastoma	neuroblastoma	NOUN
dti-1375	410	12	,	,	PUNCT
dti-1375	410	13	at	at	ADP
dti-1375	410	14	this	this	DET
dti-1375	410	15	point	point	NOUN
dti-1375	410	16	in	in	ADP
dti-1375	410	17	time	time	NOUN
dti-1375	410	18	we	we	PRON
dti-1375	410	19	are	be	AUX
dti-1375	410	20	characterizing	characterize	VERB
dti-1375	410	21	sasps	sasp	NOUN
dti-1375	410	22	and	and	CCONJ
dti-1375	410	23	also	also	ADV
dti-1375	410	24	investigating	investigate	VERB
dti-1375	410	25	the	the	DET
dti-1375	410	26	functional	functional	ADJ
dti-1375	410	27	silencing	silencing	NOUN
dti-1375	410	28	of	of	ADP
dti-1375	410	29	p16ink4a	p16ink4a	NOUN
dti-1375	410	30	and	and	CCONJ
dti-1375	410	31	its	its	PRON
dti-1375	410	32	contribution	contribution	NOUN
dti-1375	410	33	in	in	ADP
dti-1375	410	34	bypassing	bypass	VERB
dti-1375	410	35	senescence	senescence	NOUN
dti-1375	410	36	in	in	ADP
dti-1375	410	37	imr-32	imr-32	ADP
dti-1375	410	38	cells	cell	NOUN
dti-1375	410	39	.	.	PUNCT
dti-1375	411	1	in	in	ADP
dti-1375	411	2	summary	summary	NOUN
dti-1375	411	3	,	,	PUNCT
dti-1375	411	4	both	both	CCONJ
dti-1375	411	5	cancer	cancer	NOUN
dti-1375	411	6	and	and	CCONJ
dti-1375	411	7	senescence	senescence	NOUN
dti-1375	411	8	cells	cell	NOUN
dti-1375	411	9	express	express	VERB
dti-1375	411	10	high	high	ADJ
dti-1375	411	11	amounts	amount	NOUN
dti-1375	411	12	of	of	ADP
dti-1375	411	13	hsps	hsps	NOUN
dti-1375	411	14	,	,	PUNCT
dti-1375	411	15	however	however	ADV
dti-1375	411	16	,	,	PUNCT
dti-1375	411	17	differ	differ	VERB
dti-1375	411	18	in	in	ADP
dti-1375	411	19	their	their	PRON
dti-1375	411	20	chaperoning	chaperone	VERB
dti-1375	411	21	activities	activity	NOUN
dti-1375	411	22	.	.	PUNCT
dti-1375	412	1	while	while	SCONJ
dti-1375	412	2	enhanced	enhance	VERB
dti-1375	412	3	chaperoning	chaperoning	NOUN
dti-1375	412	4	functions	function	NOUN
dti-1375	412	5	of	of	ADP
dti-1375	412	6	hsp90	hsp90	NOUN
dti-1375	412	7	with	with	ADP
dti-1375	412	8	increased	increase	VERB
dti-1375	412	9	atp	atp	NOUN
dti-1375	412	10	binding	bind	VERB
dti-1375	412	11	affinity	affinity	NOUN
dti-1375	412	12	promote	promote	VERB
dti-1375	412	13	tumor	tumor	NOUN
dti-1375	412	14	progression	progression	NOUN
dti-1375	412	15	allowing	allow	VERB
dti-1375	412	16	mutated	mutate	VERB
dti-1375	412	17	gene	gene	NOUN
dti-1375	412	18	products	product	NOUN
dti-1375	412	19	to	to	PART
dti-1375	412	20	function	function	VERB
dti-1375	412	21	normally	normally	ADV
dti-1375	412	22	,	,	PUNCT
dti-1375	412	23	the	the	DET
dti-1375	412	24	basal	basal	NOUN
dti-1375	412	25	functions	function	NOUN
dti-1375	412	26	help	help	VERB
dti-1375	412	27	to	to	PART
dti-1375	412	28	maintain	maintain	VERB
dti-1375	412	29	protein	protein	NOUN
dti-1375	412	30	homeostasis	homeostasis	NOUN
dti-1375	412	31	.	.	PUNCT
dti-1375	413	1	taking	take	VERB
dti-1375	413	2	leads	lead	NOUN
dti-1375	413	3	from	from	ADP
dti-1375	413	4	these	these	DET
dti-1375	413	5	findings	finding	NOUN
dti-1375	413	6	,	,	PUNCT
dti-1375	413	7	we	we	PRON
dti-1375	413	8	manipulated	manipulate	VERB
dti-1375	413	9	the	the	DET
dti-1375	413	10	chaperone	chaperone	NOUN
dti-1375	413	11	functions	function	NOUN
dti-1375	413	12	of	of	ADP
dti-1375	413	13	hsp90	hsp90	PROPN
dti-1375	413	14	and	and	CCONJ
dti-1375	413	15	studied	study	VERB
dti-1375	413	16	genotoxic	genotoxic	ADJ
dti-1375	413	17	drug	drug	NOUN
dti-1375	413	18	-	-	PUNCT
dti-1375	413	19	induced	induce	VERB
dti-1375	413	20	cellular	cellular	ADJ
dti-1375	413	21	senescence	senescence	NOUN
dti-1375	413	22	in	in	ADP
dti-1375	413	23	imr32	imr32	ADJ
dti-1375	413	24	neuroblastoma	neuroblastoma	NOUN
dti-1375	413	25	.	.	PUNCT
dti-1375	414	1	among	among	ADP
dti-1375	414	2	different	different	ADJ
dti-1375	414	3	individual	individual	ADJ
dti-1375	414	4	and	and	CCONJ
dti-1375	414	5	combination	combination	NOUN
dti-1375	414	6	drug	drug	NOUN
dti-1375	414	7	treatments	treatment	NOUN
dti-1375	414	8	,	,	PUNCT
dti-1375	414	9	pre	pre	NOUN
dti-1375	414	10	-	-	NOUN
dti-1375	414	11	sensitization	sensitization	NOUN
dti-1375	414	12	of	of	ADP
dti-1375	414	13	neuroblastoma	neuroblastoma	NOUN
dti-1375	414	14	with	with	SCONJ
dti-1375	414	15	17aag	17aag	NOUN
dti-1375	414	16	accelerated	accelerate	VERB
dti-1375	414	17	doxorubicin	doxorubicin	PROPN
dti-1375	414	18	induced	induce	VERB
dti-1375	414	19	ddr	ddr	PROPN
dti-1375	414	20	and	and	CCONJ
dti-1375	414	21	signaled	signal	VERB
dti-1375	414	22	cells	cell	NOUN
dti-1375	414	23	to	to	PART
dti-1375	414	24	stress	stress	VERB
dti-1375	414	25	induced	induce	VERB
dti-1375	414	26	cellular	cellular	ADJ
dti-1375	414	27	senescence	senescence	NOUN
dti-1375	414	28	.	.	PUNCT
dti-1375	415	1	despite	despite	SCONJ
dti-1375	415	2	its	its	PRON
dti-1375	415	3	known	know	VERB
dti-1375	415	4	functions	function	NOUN
dti-1375	415	5	in	in	ADP
dti-1375	415	6	replicative	replicative	ADJ
dti-1375	415	7	senescence67,68	senescence67,68	AUX
dti-1375	415	8	we	we	PRON
dti-1375	415	9	demonstrate	demonstrate	VERB
dti-1375	415	10	how	how	SCONJ
dti-1375	415	11	ddr	ddr	ADJ
dti-1375	415	12	signaling	signal	VERB
dti-1375	415	13	promote	promote	VERB
dti-1375	415	14	stress	stress	NOUN
dti-1375	415	15	-	-	PUNCT
dti-1375	415	16	induced	induce	VERB
dti-1375	415	17	senescence	senescence	NOUN
dti-1375	415	18	.	.	PUNCT
dti-1375	416	1	several	several	ADJ
dti-1375	416	2	cellular	cellular	ADJ
dti-1375	416	3	factors	factor	NOUN
dti-1375	416	4	,	,	PUNCT
dti-1375	416	5	signaling	signal	VERB
dti-1375	416	6	molecules	molecule	NOUN
dti-1375	416	7	and	and	CCONJ
dti-1375	416	8	second	second	ADJ
dti-1375	416	9	messengers	messenger	NOUN
dti-1375	416	10	that	that	PRON
dti-1375	416	11	have	have	AUX
dti-1375	416	12	contributed	contribute	VERB
dti-1375	416	13	to	to	ADP
dti-1375	416	14	enforced	enforce	VERB
dti-1375	416	15	senescence	senescence	NOUN
dti-1375	416	16	in	in	ADP
dti-1375	416	17	imr-32	imr-32	ADV
dti-1375	416	18	neuroblastoma	neuroblastoma	NOUN
dti-1375	416	19	were	be	AUX
dti-1375	416	20	discussed	discuss	VERB
dti-1375	416	21	.	.	PUNCT
dti-1375	417	1	essentially	essentially	ADV
dti-1375	417	2	hsp90	hsp90	VERB
dti-1375	417	3	as	as	ADP
dti-1375	417	4	a	a	DET
dti-1375	417	5	barrier	barrier	NOUN
dti-1375	417	6	for	for	ADP
dti-1375	417	7	enforced	enforce	VERB
dti-1375	417	8	senescence	senescence	NOUN
dti-1375	417	9	in	in	ADP
dti-1375	417	10	tumor	tumor	NOUN
dti-1375	417	11	cells	cell	NOUN
dti-1375	417	12	was	be	AUX
dti-1375	417	13	emphasized	emphasize	VERB
dti-1375	417	14	(	(	PUNCT
dti-1375	417	15	fig	fig	NOUN
dti-1375	417	16	.	.	PUNCT
dti-1375	418	1	7b	7b	NOUN
dti-1375	418	2	)	)	PUNCT
dti-1375	418	3	.	.	PUNCT
dti-1375	419	1	our	our	PRON
dti-1375	419	2	findings	finding	NOUN
dti-1375	419	3	add	add	VERB
dti-1375	419	4	contemporary	contemporary	ADJ
dti-1375	419	5	information	information	NOUN
dti-1375	419	6	,	,	PUNCT
dti-1375	419	7	attractive	attractive	ADJ
dti-1375	419	8	strategy	strategy	NOUN
dti-1375	419	9	and	and	CCONJ
dti-1375	419	10	effective	effective	ADJ
dti-1375	419	11	therapeutic	therapeutic	ADJ
dti-1375	419	12	option	option	NOUN
dti-1375	419	13	wherein	wherein	ADJ
dti-1375	419	14	exploitation	exploitation	NOUN
dti-1375	419	15	of	of	ADP
dti-1375	419	16	conformation	conformation	NOUN
dti-1375	419	17	specific	specific	ADJ
dti-1375	419	18	hsp90	hsp90	NOUN
dti-1375	419	19	in	in	ADP
dti-1375	419	20	sensitizing	sensitize	VERB
dti-1375	419	21	metastatic	metastatic	ADJ
dti-1375	419	22	tumor	tumor	NOUN
dti-1375	419	23	cells	cell	NOUN
dti-1375	419	24	leads	lead	VERB
dti-1375	419	25	to	to	ADP
dti-1375	419	26	enforced	enforce	VERB
dti-1375	419	27	cellular	cellular	ADJ
dti-1375	419	28	senescence	senescence	NOUN
dti-1375	419	29	.	.	PUNCT
dti-1375	420	1	http://www.la-press.com	http://www.la-press.com	X
dti-1375	421	1	hsp90	hsp90	ADJ
dti-1375	421	2	inhibition	inhibition	NOUN
dti-1375	421	3	accelerates	accelerate	VERB
dti-1375	421	4	senescence	senescence	NOUN
dti-1375	421	5	drug	drug	NOUN
dti-1375	421	6	target	target	NOUN
dti-1375	421	7	insights	insight	NOUN
dti-1375	421	8	2012:6	2012:6	NUM
dti-1375	421	9	35	35	NUM
dti-1375	421	10	author	author	NOUN
dti-1375	421	11	contributions	contribution	VERB
dti-1375	421	12	us	we	PRON
dti-1375	421	13	,	,	PUNCT
dti-1375	421	14	krp	krp	PROPN
dti-1375	421	15	,	,	PUNCT
dti-1375	421	16	juk	juk	PROPN
dti-1375	421	17	and	and	CCONJ
dti-1375	421	18	vs	vs	ADP
dti-1375	421	19	performed	perform	VERB
dti-1375	421	20	the	the	DET
dti-1375	421	21	experiments	experiment	NOUN
dti-1375	421	22	and	and	CCONJ
dti-1375	421	23	acquired	acquire	VERB
dti-1375	421	24	the	the	DET
dti-1375	421	25	data	datum	NOUN
dti-1375	421	26	.	.	PUNCT
dti-1375	422	1	ass	ass	NOUN
dti-1375	422	2	conceived	conceive	VERB
dti-1375	422	3	the	the	DET
dti-1375	422	4	hypothesis	hypothesis	NOUN
dti-1375	422	5	,	,	PUNCT
dti-1375	422	6	designed	design	VERB
dti-1375	422	7	the	the	DET
dti-1375	422	8	experiments	experiment	NOUN
dti-1375	422	9	,	,	PUNCT
dti-1375	422	10	analyzed	analyze	VERB
dti-1375	422	11	the	the	DET
dti-1375	422	12	data	datum	NOUN
dti-1375	422	13	and	and	CCONJ
dti-1375	422	14	wrote	write	VERB
dti-1375	422	15	the	the	DET
dti-1375	422	16	manuscript	manuscript	NOUN
dti-1375	422	17	.	.	PUNCT
dti-1375	423	1	abbreviations	abbreviation	NOUN
dti-1375	423	2	hsp	hsp	X
dti-1375	423	3	,	,	PUNCT
dti-1375	423	4	heat	heat	NOUN
dti-1375	423	5	shock	shock	NOUN
dti-1375	423	6	protein	protein	NOUN
dti-1375	423	7	;	;	PUNCT
dti-1375	423	8	hsp90	hsp90	VERB
dti-1375	423	9	,	,	PUNCT
dti-1375	423	10	90	90	NUM
dti-1375	423	11	kda	kda	NOUN
dti-1375	423	12	heat	heat	NOUN
dti-1375	423	13	shock	shock	NOUN
dti-1375	423	14	protein	protein	NOUN
dti-1375	423	15	;	;	PUNCT
dti-1375	423	16	17aag	17aag	NOUN
dti-1375	423	17	,	,	PUNCT
dti-1375	423	18	17	17	NUM
dti-1375	423	19	-	-	PUNCT
dti-1375	423	20	allylamino-17	allylamino-17	NOUN
dti-1375	423	21	-	-	PUNCT
dti-1375	423	22	demethoxygeldanamycin	demethoxygeldanamycin	PROPN
dti-1375	423	23	;	;	PUNCT
dti-1375	423	24	sa	sa	AUX
dti-1375	423	25	-	-	PUNCT
dti-1375	423	26	β	β	NOUN
dti-1375	423	27	-	-	ADJ
dti-1375	423	28	gal	gal	ADJ
dti-1375	423	29	,	,	PUNCT
dti-1375	423	30	senescence	senescence	NOUN
dti-1375	423	31	-	-	PUNCT
dti-1375	423	32	associated	associate	VERB
dti-1375	423	33	β	β	NOUN
dti-1375	423	34	-	-	NOUN
dti-1375	423	35	galactosidase	galactosidase	NOUN
dti-1375	423	36	;	;	PUNCT
dti-1375	423	37	h3k4me3	h3k4me3	NOUN
dti-1375	423	38	,	,	PUNCT
dti-1375	423	39	trimethylation	trimethylation	NOUN
dti-1375	423	40	of	of	ADP
dti-1375	423	41	histone	histone	NOUN
dti-1375	423	42	h3	h3	NOUN
dti-1375	423	43	at	at	ADP
dti-1375	423	44	lysine	lysine	NOUN
dti-1375	423	45	4	4	NUM
dti-1375	423	46	;	;	PUNCT
dti-1375	423	47	ddr	ddr	PROPN
dti-1375	423	48	,	,	PUNCT
dti-1375	423	49	dna	dna	ADJ
dti-1375	423	50	damage	damage	NOUN
dti-1375	423	51	response	response	NOUN
dti-1375	423	52	;	;	PUNCT
dti-1375	423	53	γh2ax	γh2ax	NUM
dti-1375	423	54	,	,	PUNCT
dti-1375	423	55	phosphorylated	phosphorylate	VERB
dti-1375	423	56	histone	histone	NOUN
dti-1375	423	57	h2a	h2a	NOUN
dti-1375	423	58	;	;	PUNCT
dti-1375	424	1	[	[	X
dti-1375	424	2	(	(	PUNCT
dti-1375	424	3	ros)i	ros)i	NOUN
dti-1375	424	4	]	]	PUNCT
dti-1375	424	5	,	,	PUNCT
dti-1375	424	6	intracellular	intracellular	ADJ
dti-1375	424	7	reactive	reactive	ADJ
dti-1375	424	8	oxygen	oxygen	NOUN
dti-1375	424	9	species	specie	NOUN
dti-1375	424	10	;	;	PUNCT
dti-1375	424	11	[	[	X
dti-1375	424	12	(	(	PUNCT
dti-1375	424	13	ca2+)i	ca2+)i	NOUN
dti-1375	424	14	]	]	X
dti-1375	424	15	,	,	PUNCT
dti-1375	424	16	intracellular	intracellular	ADJ
dti-1375	424	17	calcium	calcium	NOUN
dti-1375	424	18	;	;	PUNCT
dti-1375	424	19	∆ψm	∆ψm	NOUN
dti-1375	424	20	,	,	PUNCT
dti-1375	424	21	change	change	NOUN
dti-1375	424	22	in	in	ADP
dti-1375	424	23	mitochondrial	mitochondrial	ADJ
dti-1375	424	24	membrane	membrane	NOUN
dti-1375	424	25	potential	potential	NOUN
dti-1375	424	26	;	;	PUNCT
dti-1375	424	27	cm	cm	NOUN
dti-1375	424	28	,	,	PUNCT
dti-1375	424	29	conditioned	condition	VERB
dti-1375	424	30	medium	medium	NOUN
dti-1375	424	31	;	;	PUNCT
dti-1375	424	32	sasp	sasp	NOUN
dti-1375	424	33	,	,	PUNCT
dti-1375	424	34	senescence	senescence	NOUN
dti-1375	424	35	-	-	PUNCT
dti-1375	424	36	associated	associate	VERB
dti-1375	424	37	secretory	secretory	ADJ
dti-1375	424	38	phenotype	phenotype	NOUN
dti-1375	424	39	;	;	PUNCT
dti-1375	424	40	sahf	sahf	NOUN
dti-1375	424	41	,	,	PUNCT
dti-1375	424	42	senescence	senescence	NOUN
dti-1375	424	43	associated	associate	VERB
dti-1375	424	44	heterochromatin	heterochromatin	NOUN
dti-1375	424	45	foci	focus	NOUN
dti-1375	424	46	;	;	PUNCT
dti-1375	424	47	rh123	rh123	NOUN
dti-1375	424	48	,	,	PUNCT
dti-1375	424	49	rhodamine	rhodamine	NOUN
dti-1375	424	50	123	123	NUM
dti-1375	424	51	;	;	PUNCT
dti-1375	424	52	facs	fac	NOUN
dti-1375	424	53	,	,	PUNCT
dti-1375	424	54	fluorescence	fluorescence	NOUN
dti-1375	424	55	activated	activate	VERB
dti-1375	424	56	cell	cell	NOUN
dti-1375	424	57	sorting	sorting	NOUN
dti-1375	424	58	;	;	PUNCT
dti-1375	424	59	mdr1	mdr1	PROPN
dti-1375	424	60	,	,	PUNCT
dti-1375	424	61	multidrug	multidrug	VERB
dti-1375	424	62	resistance	resistance	NOUN
dti-1375	424	63	gene	gene	NOUN
dti-1375	424	64	;	;	PUNCT
dti-1375	424	65	mrp	mrp	NOUN
dti-1375	424	66	,	,	PUNCT
dti-1375	424	67	multidrug	multidrug	VERB
dti-1375	424	68	related	related	ADJ
dti-1375	424	69	protein	protein	NOUN
dti-1375	424	70	;	;	PUNCT
dti-1375	424	71	p21cip	p21cip	PROPN
dti-1375	424	72	/	/	SYM
dti-1375	424	73	waf-1	waf-1	NUM
dti-1375	424	74	,	,	PUNCT
dti-1375	424	75	p21	p21	PROPN
dti-1375	424	76	cdk	cdk	PROPN
dti-1375	424	77	interacting	interact	VERB
dti-1375	424	78	protein	protein	NOUN
dti-1375	424	79	1	1	NUM
dti-1375	424	80	/	/	SYM
dti-1375	424	81	wild	wild	ADJ
dti-1375	424	82	type	type	NOUN
dti-1375	424	83	p53	p53	NOUN
dti-1375	424	84	activated	activate	VERB
dti-1375	424	85	fragment	fragment	NOUN
dti-1375	424	86	1	1	NUM
dti-1375	424	87	;	;	PUNCT
dti-1375	424	88	p16ink4a	p16ink4a	NUM
dti-1375	424	89	,	,	PUNCT
dti-1375	424	90	p16	p16	VERB
dti-1375	424	91	inhibitors	inhibitor	NOUN
dti-1375	424	92	of	of	ADP
dti-1375	424	93	cdk4	cdk4	NOUN
dti-1375	424	94	;	;	PUNCT
dti-1375	424	95	sod	sod	NOUN
dti-1375	424	96	,	,	PUNCT
dti-1375	424	97	super	super	ADJ
dti-1375	424	98	oxide	oxide	NOUN
dti-1375	424	99	dismutase	dismutase	NOUN
dti-1375	424	100	;	;	PUNCT
dti-1375	424	101	sirna	sirna	PROPN
dti-1375	424	102	,	,	PUNCT
dti-1375	424	103	small	small	ADJ
dti-1375	424	104	interfering	interfere	VERB
dti-1375	424	105	rna	rna	NOUN
dti-1375	424	106	.	.	PUNCT
dti-1375	425	1	funding	fund	VERB
dti-1375	425	2	this	this	DET
dti-1375	425	3	work	work	NOUN
dti-1375	425	4	was	be	AUX
dti-1375	425	5	supported	support	VERB
dti-1375	425	6	by	by	ADP
dti-1375	425	7	grants	grant	NOUN
dti-1375	425	8	to	to	ADP
dti-1375	425	9	ass	ass	VERB
dti-1375	425	10	from	from	ADP
dti-1375	425	11	department	department	PROPN
dti-1375	425	12	of	of	ADP
dti-1375	425	13	science	science	NOUN
dti-1375	425	14	and	and	CCONJ
dti-1375	425	15	technology	technology	NOUN
dti-1375	425	16	,	,	PUNCT
dti-1375	425	17	government	government	NOUN
dti-1375	425	18	of	of	ADP
dti-1375	425	19	india	india	PROPN
dti-1375	425	20	.	.	PUNCT
dti-1375	426	1	competing	compete	VERB
dti-1375	426	2	interests	interest	NOUN
dti-1375	426	3	author(s	author(s	NOUN
dti-1375	426	4	)	)	PUNCT
dti-1375	426	5	disclose	disclose	VERB
dti-1375	426	6	no	no	DET
dti-1375	426	7	potential	potential	ADJ
dti-1375	426	8	conflicts	conflict	NOUN
dti-1375	426	9	of	of	ADP
dti-1375	426	10	interest	interest	NOUN
dti-1375	426	11	.	.	PUNCT
dti-1375	427	1	disclosures	disclosure	NOUN
dti-1375	427	2	and	and	CCONJ
dti-1375	427	3	ethics	ethic	NOUN
dti-1375	427	4	as	as	ADP
dti-1375	427	5	a	a	DET
dti-1375	427	6	requirement	requirement	NOUN
dti-1375	427	7	of	of	ADP
dti-1375	427	8	publication	publication	NOUN
dti-1375	427	9	author(s	author(s	PROPN
dti-1375	427	10	)	)	PUNCT
dti-1375	427	11	have	have	AUX
dti-1375	427	12	provided	provide	VERB
dti-1375	427	13	to	to	ADP
dti-1375	427	14	the	the	DET
dti-1375	427	15	publisher	publisher	NOUN
dti-1375	427	16	signed	sign	VERB
dti-1375	427	17	confirmation	confirmation	NOUN
dti-1375	427	18	of	of	ADP
dti-1375	427	19	compliance	compliance	NOUN
dti-1375	427	20	with	with	ADP
dti-1375	427	21	legal	legal	ADJ
dti-1375	427	22	and	and	CCONJ
dti-1375	427	23	ethical	ethical	ADJ
dti-1375	427	24	obligations	obligation	NOUN
dti-1375	427	25	including	include	VERB
dti-1375	427	26	but	but	CCONJ
dti-1375	427	27	not	not	PART
dti-1375	427	28	limited	limit	VERB
dti-1375	427	29	to	to	ADP
dti-1375	427	30	the	the	DET
dti-1375	427	31	following	following	NOUN
dti-1375	427	32	:	:	PUNCT
dti-1375	427	33	authorship	authorship	NOUN
dti-1375	427	34	and	and	CCONJ
dti-1375	427	35	contributorship	contributorship	NOUN
dti-1375	427	36	,	,	PUNCT
dti-1375	427	37	conflicts	conflict	NOUN
dti-1375	427	38	of	of	ADP
dti-1375	427	39	interest	interest	NOUN
dti-1375	427	40	,	,	PUNCT
dti-1375	427	41	privacy	privacy	NOUN
dti-1375	427	42	and	and	CCONJ
dti-1375	427	43	confidentiality	confidentiality	NOUN
dti-1375	427	44	and	and	CCONJ
dti-1375	427	45	(	(	PUNCT
dti-1375	427	46	where	where	SCONJ
dti-1375	427	47	applicable	applicable	ADJ
dti-1375	427	48	)	)	PUNCT
dti-1375	427	49	protection	protection	NOUN
dti-1375	427	50	of	of	ADP
dti-1375	427	51	human	human	ADJ
dti-1375	427	52	and	and	CCONJ
dti-1375	427	53	animal	animal	NOUN
dti-1375	427	54	research	research	NOUN
dti-1375	427	55	subjects	subject	NOUN
dti-1375	427	56	.	.	PUNCT
dti-1375	428	1	the	the	DET
dti-1375	428	2	authors	author	NOUN
dti-1375	428	3	have	have	AUX
dti-1375	428	4	read	read	VERB
dti-1375	428	5	and	and	CCONJ
dti-1375	428	6	confirmed	confirm	VERB
dti-1375	428	7	their	their	PRON
dti-1375	428	8	agreement	agreement	NOUN
dti-1375	428	9	with	with	ADP
dti-1375	428	10	the	the	DET
dti-1375	428	11	icmje	icmje	NOUN
dti-1375	428	12	authorship	authorship	NOUN
dti-1375	428	13	and	and	CCONJ
dti-1375	428	14	conflict	conflict	NOUN
dti-1375	428	15	of	of	ADP
dti-1375	428	16	interest	interest	NOUN
dti-1375	428	17	criteria	criterion	NOUN
dti-1375	428	18	.	.	PUNCT
dti-1375	429	1	the	the	DET
dti-1375	429	2	authors	author	NOUN
dti-1375	429	3	have	have	AUX
dti-1375	429	4	also	also	ADV
dti-1375	429	5	confirmed	confirm	VERB
dti-1375	429	6	that	that	SCONJ
dti-1375	429	7	this	this	DET
dti-1375	429	8	article	article	NOUN
dti-1375	429	9	is	be	AUX
dti-1375	429	10	unique	unique	ADJ
dti-1375	429	11	and	and	CCONJ
dti-1375	429	12	not	not	PART
dti-1375	429	13	under	under	ADP
dti-1375	429	14	consideration	consideration	NOUN
dti-1375	429	15	or	or	CCONJ
dti-1375	429	16	published	publish	VERB
dti-1375	429	17	in	in	ADP
dti-1375	429	18	any	any	DET
dti-1375	429	19	other	other	ADJ
dti-1375	429	20	publication	publication	NOUN
dti-1375	429	21	,	,	PUNCT
dti-1375	429	22	and	and	CCONJ
dti-1375	429	23	that	that	SCONJ
dti-1375	429	24	they	they	PRON
dti-1375	429	25	have	have	VERB
dti-1375	429	26	permission	permission	NOUN
dti-1375	429	27	from	from	ADP
dti-1375	429	28	rights	right	NOUN
dti-1375	429	29	holders	holder	NOUN
dti-1375	429	30	to	to	PART
dti-1375	429	31	reproduce	reproduce	VERB
dti-1375	429	32	any	any	DET
dti-1375	429	33	copyrighted	copyright	VERB
dti-1375	429	34	material	material	NOUN
dti-1375	429	35	.	.	PUNCT
dti-1375	430	1	any	any	DET
dti-1375	430	2	disclosures	disclosure	NOUN
dti-1375	430	3	are	be	AUX
dti-1375	430	4	made	make	VERB
dti-1375	430	5	in	in	ADP
dti-1375	430	6	this	this	DET
dti-1375	430	7	section	section	NOUN
dti-1375	430	8	.	.	PUNCT
dti-1375	431	1	the	the	DET
dti-1375	431	2	external	external	ADJ
dti-1375	431	3	blind	blind	ADJ
dti-1375	431	4	peer	peer	NOUN
dti-1375	431	5	reviewers	reviewer	NOUN
dti-1375	431	6	report	report	VERB
dti-1375	431	7	no	no	DET
dti-1375	431	8	conflicts	conflict	NOUN
dti-1375	431	9	of	of	ADP
dti-1375	431	10	interest	interest	NOUN
dti-1375	431	11	.	.	PUNCT
dti-1375	432	1	references	reference	NOUN
dti-1375	432	2	1	1	NUM
dti-1375	432	3	.	.	PUNCT
dti-1375	432	4	sreedhar	sreedhar	NOUN
dti-1375	432	5	as	as	ADP
dti-1375	432	6	,	,	PUNCT
dti-1375	432	7	csermely	csermely	ADV
dti-1375	432	8	p.	p.	NOUN
dti-1375	432	9	heat	heat	NOUN
dti-1375	432	10	shock	shock	NOUN
dti-1375	432	11	proteins	protein	NOUN
dti-1375	432	12	in	in	ADP
dti-1375	432	13	the	the	DET
dti-1375	432	14	regulation	regulation	NOUN
dti-1375	432	15	of	of	ADP
dti-1375	432	16	apoptosis	apoptosis	NOUN
dti-1375	432	17	:	:	PUNCT
dti-1375	432	18	new	new	ADJ
dti-1375	432	19	strategies	strategy	NOUN
dti-1375	432	20	in	in	ADP
dti-1375	432	21	tumor	tumor	NOUN
dti-1375	432	22	therapy	therapy	NOUN
dti-1375	432	23	:	:	PUNCT
dti-1375	432	24	a	a	DET
dti-1375	432	25	comprehensive	comprehensive	ADJ
dti-1375	432	26	review	review	NOUN
dti-1375	432	27	.	.	PUNCT
dti-1375	433	1	pharmacol	pharmacol	VERB
dti-1375	433	2	ther	ther	ADV
dti-1375	433	3	.	.	PUNCT
dti-1375	434	1	2004;101:227–54	2004;101:227–54	X
dti-1375	434	2	.	.	NOUN
dti-1375	434	3	2	2	NUM
dti-1375	434	4	.	.	X
dti-1375	434	5	whitesell	whitesell	PROPN
dti-1375	434	6	l	l	PROPN
dti-1375	434	7	,	,	PUNCT
dti-1375	434	8	lindquist	lindquist	PROPN
dti-1375	434	9	s.	s.	PROPN
dti-1375	434	10	hsp90	hsp90	VERB
dti-1375	434	11	and	and	CCONJ
dti-1375	434	12	the	the	DET
dti-1375	434	13	chaperoning	chaperoning	NOUN
dti-1375	434	14	of	of	ADP
dti-1375	434	15	cancer	cancer	NOUN
dti-1375	434	16	.	.	PUNCT
dti-1375	435	1	nat	nat	PROPN
dti-1375	435	2	rev	rev	PROPN
dti-1375	435	3	cancer	cancer	NOUN
dti-1375	435	4	.	.	PUNCT
dti-1375	436	1	2005;5:761–72	2005;5:761–72	NUM
dti-1375	436	2	.	.	NOUN
dti-1375	436	3	3	3	NUM
dti-1375	436	4	.	.	NUM
dti-1375	436	5	cid	cid	PROPN
dti-1375	436	6	c	c	NOUN
dti-1375	436	7	,	,	PUNCT
dti-1375	436	8	regidor	regidor	VERB
dti-1375	436	9	i	i	PRON
dti-1375	436	10	,	,	PUNCT
dti-1375	436	11	poveda	poveda	PROPN
dti-1375	436	12	pd	pd	PROPN
dti-1375	436	13	,	,	PUNCT
dti-1375	436	14	alcazar	alcazar	PROPN
dti-1375	436	15	a.	a.	NOUN
dti-1375	436	16	expression	expression	NOUN
dti-1375	436	17	of	of	ADP
dti-1375	436	18	heat	heat	NOUN
dti-1375	436	19	shock	shock	NOUN
dti-1375	436	20	protein	protein	NOUN
dti-1375	436	21	90	90	NUM
dti-1375	436	22	at	at	ADP
dti-1375	436	23	the	the	DET
dti-1375	436	24	cell	cell	NOUN
dti-1375	436	25	surface	surface	NOUN
dti-1375	436	26	in	in	ADP
dti-1375	436	27	neuroblastoma	neuroblastoma	ADJ
dti-1375	436	28	cells	cell	NOUN
dti-1375	436	29	.	.	PUNCT
dti-1375	437	1	cell	cell	NOUN
dti-1375	437	2	stress	stress	NOUN
dti-1375	437	3	and	and	CCONJ
dti-1375	437	4	chaperones	chaperone	NOUN
dti-1375	437	5	.	.	PUNCT
dti-1375	438	1	2009;14:321–7	2009;14:321–7	NUM
dti-1375	438	2	.	.	PUNCT
dti-1375	439	1	4	4	NUM
dti-1375	439	2	.	.	X
dti-1375	439	3	sumizawa	sumizawa	PROPN
dti-1375	439	4	t	t	PROPN
dti-1375	439	5	,	,	PUNCT
dti-1375	439	6	igishu	igishu	NOUN
dti-1375	439	7	h.	h.	PROPN
dti-1375	439	8	release	release	PROPN
dti-1375	439	9	of	of	ADP
dti-1375	439	10	heat	heat	NOUN
dti-1375	439	11	shock	shock	NOUN
dti-1375	439	12	proteins	protein	NOUN
dti-1375	439	13	from	from	ADP
dti-1375	439	14	neurblastoma	neurblastoma	ADJ
dti-1375	439	15	cells	cell	NOUN
dti-1375	439	16	exposed	expose	VERB
dti-1375	439	17	to	to	ADP
dti-1375	439	18	acrylamide	acrylamide	NOUN
dti-1375	439	19	.	.	PUNCT
dti-1375	440	1	j	j	PROPN
dti-1375	440	2	toxicol	toxicol	PROPN
dti-1375	440	3	sci	sci	PROPN
dti-1375	440	4	.	.	PUNCT
dti-1375	441	1	2008;33:117–22	2008;33:117–22	NUM
dti-1375	441	2	.	.	PROPN
dti-1375	442	1	5	5	NUM
dti-1375	442	2	.	.	PUNCT
dti-1375	443	1	kim	kim	PROPN
dti-1375	443	2	s	s	PROPN
dti-1375	443	3	,	,	PUNCT
dti-1375	443	4	kang	kang	PROPN
dti-1375	443	5	j	j	PROPN
dti-1375	443	6	,	,	PUNCT
dti-1375	443	7	hu	hu	PROPN
dti-1375	443	8	w	w	PROPN
dti-1375	443	9	,	,	PUNCT
dti-1375	443	10	evans	evans	PROPN
dti-1375	443	11	bm	bm	PROPN
dti-1375	443	12	,	,	PUNCT
dti-1375	443	13	chung	chung	PROPN
dti-1375	443	14	dh	dh	PROPN
dti-1375	443	15	.	.	PUNCT
dti-1375	444	1	geldanamycin	geldanamycin	PROPN
dti-1375	444	2	decrases	decrase	NOUN
dti-1375	444	3	raf-1	raf-1	NUM
dti-1375	444	4	and	and	CCONJ
dti-1375	444	5	akt	akt	PROPN
dti-1375	444	6	levels	level	NOUN
dti-1375	444	7	and	and	CCONJ
dti-1375	444	8	induces	induce	VERB
dti-1375	444	9	apotposis	apotposis	NOUN
dti-1375	444	10	in	in	ADP
dti-1375	444	11	neuroblastomas	neuroblastoma	NOUN
dti-1375	444	12	.	.	PUNCT
dti-1375	445	1	int	int	PROPN
dti-1375	445	2	j	j	PROPN
dti-1375	445	3	cancer	cancer	NOUN
dti-1375	445	4	.	.	PUNCT
dti-1375	446	1	2003;103:352–9	2003;103:352–9	X
dti-1375	446	2	.	.	NOUN
dti-1375	446	3	6	6	NUM
dti-1375	446	4	.	.	X
dti-1375	446	5	taiyab	taiyab	NOUN
dti-1375	446	6	a	a	PRON
dti-1375	446	7	,	,	PUNCT
dti-1375	446	8	srinivas	srinivas	PROPN
dti-1375	446	9	uk	uk	PROPN
dti-1375	446	10	,	,	PUNCT
dti-1375	446	11	sreedhar	sreedhar	ADJ
dti-1375	446	12	as	as	ADP
dti-1375	446	13	.	.	PUNCT
dti-1375	446	14	17-(allylamino)-17	17-(allylamino)-17	PROPN
dti-1375	446	15	-	-	PUNCT
dti-1375	446	16	demethoxygeldanamycin	demethoxygeldanamycin	PROPN
dti-1375	446	17	combination	combination	NOUN
dti-1375	446	18	with	with	ADP
dti-1375	446	19	diferuloylmethane	diferuloylmethane	NOUN
dti-1375	446	20	selectively	selectively	ADV
dti-1375	446	21	targets	target	VERB
dti-1375	446	22	mitogen	mitogen	PROPN
dti-1375	446	23	kinase	kinase	PROPN
dti-1375	446	24	pathway	pathway	NOUN
dti-1375	446	25	in	in	ADP
dti-1375	446	26	a	a	DET
dti-1375	446	27	human	human	ADJ
dti-1375	446	28	neuroblastoma	neuroblastoma	NOUN
dti-1375	446	29	cell	cell	NOUN
dti-1375	446	30	line	line	NOUN
dti-1375	446	31	.	.	PUNCT
dti-1375	447	1	j	j	PROPN
dti-1375	447	2	cancer	cancer	NOUN
dti-1375	447	3	ther	ther	ADV
dti-1375	447	4	.	.	PUNCT
dti-1375	448	1	2010;1:197–204	2010;1:197–204	NUM
dti-1375	448	2	.	.	PUNCT
dti-1375	449	1	7	7	X
dti-1375	449	2	.	.	X
dti-1375	449	3	pratt	pratt	PROPN
dti-1375	449	4	wb	wb	PROPN
dti-1375	449	5	,	,	PUNCT
dti-1375	449	6	toft	toft	PROPN
dti-1375	449	7	do	do	VERB
dti-1375	449	8	.	.	PUNCT
dti-1375	450	1	regulation	regulation	NOUN
dti-1375	450	2	of	of	ADP
dti-1375	450	3	signaling	signal	VERB
dti-1375	450	4	protein	protein	NOUN
dti-1375	450	5	function	function	NOUN
dti-1375	450	6	and	and	CCONJ
dti-1375	450	7	trafficking	trafficking	NOUN
dti-1375	450	8	by	by	ADP
dti-1375	450	9	the	the	DET
dti-1375	450	10	hsp90	hsp90	PROPN
dti-1375	450	11	/	/	SYM
dti-1375	450	12	hsp70	hsp70	NOUN
dti-1375	450	13	-	-	PUNCT
dti-1375	450	14	based	base	VERB
dti-1375	450	15	chaperone	chaperone	NOUN
dti-1375	450	16	machinery	machinery	NOUN
dti-1375	450	17	.	.	PUNCT
dti-1375	451	1	exp	exp	NOUN
dti-1375	451	2	biol	biol	PROPN
dti-1375	451	3	med	med	PROPN
dti-1375	451	4	(	(	PUNCT
dti-1375	451	5	maywood	maywood	PROPN
dti-1375	451	6	)	)	PUNCT
dti-1375	451	7	.	.	PUNCT
dti-1375	452	1	2003;228:111–33	2003;228:111–33	PROPN
dti-1375	452	2	.	.	PUNCT
dti-1375	453	1	8	8	X
dti-1375	453	2	.	.	X
dti-1375	453	3	sreedhar	sreedhar	NOUN
dti-1375	453	4	as	as	ADP
dti-1375	453	5	,	,	PUNCT
dti-1375	453	6	soti	soti	NOUN
dti-1375	453	7	c	c	NOUN
dti-1375	453	8	,	,	PUNCT
dti-1375	453	9	csermely	csermely	ADV
dti-1375	453	10	p.	p.	NOUN
dti-1375	453	11	inhibition	inhibition	NOUN
dti-1375	453	12	of	of	ADP
dti-1375	453	13	hsp90	hsp90	NOUN
dti-1375	453	14	:	:	PUNCT
dti-1375	453	15	a	a	DET
dti-1375	453	16	new	new	ADJ
dti-1375	453	17	strategy	strategy	NOUN
dti-1375	453	18	for	for	ADP
dti-1375	453	19	inhibiting	inhibit	VERB
dti-1375	453	20	protein	protein	NOUN
dti-1375	453	21	kinases	kinase	NOUN
dti-1375	453	22	.	.	PUNCT
dti-1375	454	1	biochim	biochim	PROPN
dti-1375	454	2	biophys	biophy	NOUN
dti-1375	454	3	acta	acta	PROPN
dti-1375	454	4	.	.	PUNCT
dti-1375	455	1	2004;1697	2004;1697	X
dti-1375	455	2	:	:	PUNCT
dti-1375	455	3	233–42	233–42	NUM
dti-1375	455	4	.	.	NOUN
dti-1375	455	5	9	9	NUM
dti-1375	455	6	.	.	X
dti-1375	455	7	xue	xue	PROPN
dti-1375	455	8	c	c	PROPN
dti-1375	455	9	,	,	PUNCT
dti-1375	455	10	haber	haber	PROPN
dti-1375	455	11	m	m	PROPN
dti-1375	455	12	,	,	PUNCT
dti-1375	455	13	flemming	flemme	VERB
dti-1375	455	14	c	c	X
dti-1375	455	15	,	,	PUNCT
dti-1375	455	16	et	et	PROPN
dti-1375	455	17	al	al	PROPN
dti-1375	455	18	.	.	PROPN
dti-1375	455	19	p53	p53	PROPN
dti-1375	455	20	determines	determine	VERB
dti-1375	455	21	multidrug	multidrug	VERB
dti-1375	455	22	resistance	resistance	NOUN
dti-1375	455	23	of	of	ADP
dti-1375	455	24	childhood	childhood	NOUN
dti-1375	455	25	neuroblastoma	neuroblastoma	NOUN
dti-1375	455	26	.	.	PUNCT
dti-1375	456	1	cancer	cancer	NOUN
dti-1375	456	2	res	re	NOUN
dti-1375	456	3	.	.	PUNCT
dti-1375	457	1	2007;67:10351–60	2007;67:10351–60	NUM
dti-1375	457	2	.	.	NOUN
dti-1375	457	3	10	10	NUM
dti-1375	457	4	.	.	PUNCT
dti-1375	457	5	diccianni	diccianni	PROPN
dti-1375	457	6	mb	mb	PROPN
dti-1375	457	7	,	,	PUNCT
dti-1375	457	8	omura	omura	NOUN
dti-1375	457	9	-	-	PUNCT
dti-1375	457	10	minamisawa	minamisawa	PROPN
dti-1375	457	11	m	m	PROPN
dti-1375	457	12	,	,	PUNCT
dti-1375	457	13	batova	batova	VERB
dti-1375	457	14	a	a	PRON
dti-1375	457	15	,	,	PUNCT
dti-1375	457	16	le	le	PROPN
dti-1375	457	17	t	t	PROPN
dti-1375	457	18	,	,	PUNCT
dti-1375	457	19	bridgeman	bridgeman	PROPN
dti-1375	457	20	l	l	PROPN
dti-1375	457	21	,	,	PUNCT
dti-1375	457	22	yu	yu	PROPN
dti-1375	458	1	al	al	PROPN
dti-1375	458	2	.	.	PUNCT
dti-1375	458	3	frequent	frequent	ADJ
dti-1375	458	4	deregulation	deregulation	NOUN
dti-1375	458	5	of	of	ADP
dti-1375	458	6	p16	p16	NOUN
dti-1375	458	7	and	and	CCONJ
dti-1375	458	8	p16	p16	NOUN
dti-1375	458	9	/	/	SYM
dti-1375	458	10	g1	g1	PROPN
dti-1375	458	11	cell	cell	NOUN
dti-1375	458	12	cycle	cycle	NOUN
dti-1375	458	13	-	-	PUNCT
dti-1375	458	14	regulatory	regulatory	ADJ
dti-1375	458	15	pathway	pathway	NOUN
dti-1375	458	16	in	in	ADP
dti-1375	458	17	neuroblastoma	neuroblastoma	NOUN
dti-1375	458	18	.	.	PUNCT
dti-1375	459	1	int	int	NOUN
dti-1375	459	2	j	j	PROPN
dti-1375	459	3	cancer	cancer	NOUN
dti-1375	459	4	.	.	PUNCT
dti-1375	460	1	1999;80:145–54	1999;80:145–54	NUM
dti-1375	460	2	.	.	NOUN
dti-1375	460	3	11	11	NUM
dti-1375	460	4	.	.	PUNCT
dti-1375	461	1	wendel	wendel	PROPN
dti-1375	461	2	hg	hg	PROPN
dti-1375	461	3	,	,	PUNCT
dti-1375	461	4	de	de	PROPN
dti-1375	461	5	stanchina	stanchina	PROPN
dti-1375	461	6	e	e	PROPN
dti-1375	461	7	,	,	PUNCT
dti-1375	461	8	fridman	fridman	ADJ
dti-1375	461	9	js	js	PROPN
dti-1375	461	10	,	,	PUNCT
dti-1375	461	11	et	et	PROPN
dti-1375	461	12	al	al	PROPN
dti-1375	461	13	.	.	PROPN
dti-1375	461	14	survival	survival	PROPN
dti-1375	461	15	signalling	signal	VERB
dti-1375	461	16	by	by	ADP
dti-1375	461	17	akt	akt	PROPN
dti-1375	461	18	and	and	CCONJ
dti-1375	461	19	eif4e	eif4e	VERB
dti-1375	461	20	in	in	ADP
dti-1375	461	21	oncogenesis	oncogenesis	NOUN
dti-1375	461	22	and	and	CCONJ
dti-1375	461	23	cancer	cancer	NOUN
dti-1375	461	24	therapy	therapy	NOUN
dti-1375	461	25	.	.	PUNCT
dti-1375	462	1	nature	nature	NOUN
dti-1375	462	2	.	.	PUNCT
dti-1375	463	1	2004;28:332–7	2004;28:332–7	X
dti-1375	463	2	.	.	PUNCT
dti-1375	464	1	12	12	NUM
dti-1375	464	2	.	.	PUNCT
dti-1375	465	1	fulda	fulda	PROPN
dti-1375	465	2	s.	s.	PROPN
dti-1375	465	3	apoptosis	apoptosis	PROPN
dti-1375	465	4	and	and	CCONJ
dti-1375	465	5	neuroblastoma	neuroblastoma	NOUN
dti-1375	465	6	therapy	therapy	NOUN
dti-1375	465	7	.	.	PUNCT
dti-1375	466	1	curr	curr	PROPN
dti-1375	466	2	pharma	pharma	PROPN
dti-1375	466	3	des	des	PROPN
dti-1375	466	4	.	.	PROPN
dti-1375	467	1	2009;9:729–37	2009;9:729–37	NUM
dti-1375	467	2	.	.	PUNCT
dti-1375	468	1	13	13	NUM
dti-1375	468	2	.	.	PUNCT
dti-1375	469	1	dimri	dimri	PROPN
dti-1375	469	2	gp	gp	PROPN
dti-1375	469	3	,	,	PUNCT
dti-1375	469	4	lee	lee	PROPN
dti-1375	469	5	x	x	PROPN
dti-1375	469	6	,	,	PUNCT
dti-1375	469	7	basile	basile	NOUN
dti-1375	469	8	g	g	PROPN
dti-1375	469	9	,	,	PUNCT
dti-1375	469	10	et	et	PROPN
dti-1375	469	11	al	al	PROPN
dti-1375	469	12	.	.	PROPN
dti-1375	469	13	biomarker	biomarker	NOUN
dti-1375	469	14	that	that	PRON
dti-1375	469	15	identifies	identify	VERB
dti-1375	469	16	senescent	senescent	ADJ
dti-1375	469	17	human	human	ADJ
dti-1375	469	18	cells	cell	NOUN
dti-1375	469	19	in	in	ADP
dti-1375	469	20	culture	culture	NOUN
dti-1375	469	21	and	and	CCONJ
dti-1375	469	22	in	in	ADP
dti-1375	469	23	aging	age	VERB
dti-1375	469	24	skin	skin	NOUN
dti-1375	469	25	in	in	ADP
dti-1375	469	26	vivo	vivo	NOUN
dti-1375	469	27	.	.	PUNCT
dti-1375	470	1	proc	proc	PROPN
dti-1375	470	2	natl	natl	PROPN
dti-1375	470	3	acad	acad	PROPN
dti-1375	470	4	sci	sci	PROPN
dti-1375	470	5	u	u	PROPN
dti-1375	470	6	s	s	NOUN
dti-1375	470	7	a.	a.	NOUN
dti-1375	470	8	1995;92	1995;92	NUM
dti-1375	470	9	:	:	PUNCT
dti-1375	471	1	9363–7	9363–7	NUM
dti-1375	471	2	.	.	PUNCT
dti-1375	472	1	14	14	NUM
dti-1375	472	2	.	.	PUNCT
dti-1375	472	3	kurz	kurz	PROPN
dti-1375	472	4	dj	dj	PROPN
dti-1375	472	5	,	,	PUNCT
dti-1375	472	6	decary	decary	PROPN
dti-1375	472	7	s	s	PROPN
dti-1375	472	8	,	,	PUNCT
dti-1375	472	9	hong	hong	PROPN
dti-1375	472	10	y	y	PROPN
dti-1375	472	11	,	,	PUNCT
dti-1375	472	12	erusalimsky	erusalimsky	PROPN
dti-1375	472	13	jd	jd	PROPN
dti-1375	472	14	.	.	PUNCT
dti-1375	472	15	senescence	senescence	NOUN
dti-1375	472	16	-	-	PUNCT
dti-1375	472	17	associated	associate	VERB
dti-1375	472	18	(	(	PUNCT
dti-1375	472	19	beta)galactosidase	beta)galactosidase	PROPN
dti-1375	472	20	reflects	reflect	VERB
dti-1375	472	21	an	an	DET
dti-1375	472	22	increase	increase	NOUN
dti-1375	472	23	in	in	ADP
dti-1375	472	24	lysosomal	lysosomal	ADJ
dti-1375	472	25	mass	mass	NOUN
dti-1375	472	26	during	during	ADP
dti-1375	472	27	replicative	replicative	ADJ
dti-1375	472	28	ageing	ageing	NOUN
dti-1375	472	29	of	of	ADP
dti-1375	472	30	human	human	ADJ
dti-1375	472	31	endothelial	endothelial	ADJ
dti-1375	472	32	cells	cell	NOUN
dti-1375	472	33	.	.	PUNCT
dti-1375	473	1	j	j	PROPN
dti-1375	473	2	cell	cell	PROPN
dti-1375	473	3	sci	sci	PROPN
dti-1375	473	4	.	.	PUNCT
dti-1375	473	5	2000;113:3613–22	2000;113:3613–22	NUM
dti-1375	473	6	.	.	PUNCT
dti-1375	473	7	15	15	NUM
dti-1375	473	8	.	.	PUNCT
dti-1375	474	1	kwak	kwak	PROPN
dti-1375	474	2	ih	ih	PROPN
dti-1375	474	3	,	,	PUNCT
dti-1375	474	4	kim	kim	PROPN
dti-1375	474	5	hs	hs	PROPN
dti-1375	474	6	,	,	PUNCT
dti-1375	474	7	choi	choi	NOUN
dti-1375	474	8	or	or	CCONJ
dti-1375	474	9	,	,	PUNCT
dti-1375	474	10	ryu	ryu	PROPN
dti-1375	474	11	ms	ms	PROPN
dti-1375	474	12	,	,	PUNCT
dti-1375	474	13	lim	lim	PROPN
dti-1375	474	14	ik	ik	PROPN
dti-1375	474	15	.	.	PROPN
dti-1375	474	16	nuclear	nuclear	ADJ
dti-1375	474	17	accumulation	accumulation	NOUN
dti-1375	474	18	of	of	ADP
dti-1375	474	19	globular	globular	ADJ
dti-1375	474	20	actin	actin	NOUN
dti-1375	474	21	as	as	ADP
dti-1375	474	22	a	a	DET
dti-1375	474	23	cellular	cellular	ADJ
dti-1375	474	24	senescence	senescence	NOUN
dti-1375	474	25	marker	marker	NOUN
dti-1375	474	26	.	.	PUNCT
dti-1375	475	1	cancer	cancer	NOUN
dti-1375	475	2	res	re	NOUN
dti-1375	475	3	.	.	PUNCT
dti-1375	476	1	2004;64:572–80	2004;64:572–80	X
dti-1375	476	2	.	.	PUNCT
dti-1375	477	1	16	16	NUM
dti-1375	477	2	.	.	PUNCT
dti-1375	478	1	lee	lee	PROPN
dti-1375	478	2	s	s	PROPN
dti-1375	478	3	,	,	PUNCT
dti-1375	478	4	jeong	jeong	PROPN
dti-1375	478	5	sy	sy	PROPN
dti-1375	478	6	,	,	PUNCT
dti-1375	478	7	lim	lim	PROPN
dti-1375	478	8	wc	wc	PROPN
dti-1375	478	9	,	,	PUNCT
dti-1375	478	10	et	et	PROPN
dti-1375	478	11	al	al	PROPN
dti-1375	478	12	.	.	PUNCT
dti-1375	478	13	mitochondrial	mitochondrial	ADJ
dti-1375	478	14	fission	fission	NOUN
dti-1375	478	15	and	and	CCONJ
dti-1375	478	16	fusion	fusion	NOUN
dti-1375	478	17	mediators	mediator	NOUN
dti-1375	478	18	,	,	PUNCT
dti-1375	478	19	hfis1	hfis1	NOUN
dti-1375	478	20	and	and	CCONJ
dti-1375	478	21	opa1	opa1	PROPN
dti-1375	478	22	,	,	PUNCT
dti-1375	478	23	modulate	modulate	VERB
dti-1375	478	24	cellular	cellular	ADJ
dti-1375	478	25	senescence	senescence	NOUN
dti-1375	478	26	.	.	PUNCT
dti-1375	479	1	j	j	PROPN
dti-1375	479	2	biol	biol	PROPN
dti-1375	479	3	chem	chem	NOUN
dti-1375	479	4	.	.	PUNCT
dti-1375	480	1	2007;282	2007;282	NUM
dti-1375	480	2	:	:	PUNCT
dti-1375	480	3	22977–83	22977–83	NUM
dti-1375	480	4	.	.	PUNCT
dti-1375	481	1	17	17	NUM
dti-1375	481	2	.	.	PUNCT
dti-1375	482	1	hwang	hwang	PROPN
dti-1375	482	2	es	es	PROPN
dti-1375	482	3	,	,	PUNCT
dti-1375	482	4	yoon	yoon	PROPN
dti-1375	482	5	g	g	PROPN
dti-1375	482	6	,	,	PUNCT
dti-1375	482	7	kang	kang	PROPN
dti-1375	482	8	ht	ht	PROPN
dti-1375	482	9	.	.	PUNCT
dti-1375	483	1	a	a	DET
dti-1375	483	2	comparative	comparative	ADJ
dti-1375	483	3	analysis	analysis	NOUN
dti-1375	483	4	of	of	ADP
dti-1375	483	5	the	the	DET
dti-1375	483	6	cell	cell	NOUN
dti-1375	483	7	biology	biology	NOUN
dti-1375	483	8	of	of	ADP
dti-1375	483	9	senescence	senescence	NOUN
dti-1375	483	10	and	and	CCONJ
dti-1375	483	11	aging	aging	NOUN
dti-1375	483	12	.	.	PUNCT
dti-1375	484	1	cell	cell	NOUN
dti-1375	484	2	mol	mol	ADP
dti-1375	484	3	life	life	PROPN
dti-1375	484	4	sci	sci	PROPN
dti-1375	484	5	.	.	PUNCT
dti-1375	485	1	2009;66:2503–24	2009;66:2503–24	NUM
dti-1375	485	2	.	.	PUNCT
dti-1375	486	1	18	18	NUM
dti-1375	486	2	.	.	PUNCT
dti-1375	487	1	shammas	shammas	PROPN
dti-1375	487	2	ma	ma	PROPN
dti-1375	487	3	,	,	PUNCT
dti-1375	487	4	koley	koley	VERB
dti-1375	487	5	h	h	NOUN
dti-1375	487	6	,	,	PUNCT
dti-1375	487	7	batchu	batchu	PROPN
dti-1375	487	8	rb	rb	PROPN
dti-1375	487	9	,	,	PUNCT
dti-1375	487	10	et	et	PROPN
dti-1375	487	11	al	al	PROPN
dti-1375	487	12	.	.	PUNCT
dti-1375	487	13	telomerase	telomerase	NOUN
dti-1375	487	14	inhibition	inhibition	NOUN
dti-1375	487	15	by	by	ADP
dti-1375	487	16	sirna	sirna	PROPN
dti-1375	487	17	causes	cause	VERB
dti-1375	487	18	senescence	senescence	NOUN
dti-1375	487	19	and	and	CCONJ
dti-1375	487	20	apoptosis	apoptosis	NOUN
dti-1375	487	21	in	in	ADP
dti-1375	487	22	barrett	barrett	PROPN
dti-1375	487	23	’s	’s	PART
dti-1375	487	24	adenocarcinoma	adenocarcinoma	PROPN
dti-1375	487	25	cells	cell	NOUN
dti-1375	487	26	:	:	PUNCT
dti-1375	487	27	mechanism	mechanism	NOUN
dti-1375	487	28	and	and	CCONJ
dti-1375	487	29	therapeutic	therapeutic	ADJ
dti-1375	487	30	potential	potential	NOUN
dti-1375	487	31	.	.	PUNCT
dti-1375	488	1	mol	mol	ADP
dti-1375	488	2	cancer	cancer	NOUN
dti-1375	488	3	.	.	PUNCT
dti-1375	489	1	2005;4:24	2005;4:24	ADJ
dti-1375	489	2	.	.	PUNCT
dti-1375	490	1	19	19	NUM
dti-1375	490	2	.	.	PUNCT
dti-1375	490	3	ke	ke	PROPN
dti-1375	490	4	xs	xs	PROPN
dti-1375	490	5	,	,	PUNCT
dti-1375	490	6	qu	qu	PROPN
dti-1375	490	7	y	y	PROPN
dti-1375	490	8	,	,	PUNCT
dti-1375	490	9	rostad	rostad	NOUN
dti-1375	490	10	k	k	PROPN
dti-1375	490	11	,	,	PUNCT
dti-1375	490	12	et	et	PROPN
dti-1375	490	13	al	al	PROPN
dti-1375	490	14	.	.	PUNCT
dti-1375	490	15	genome	genome	NOUN
dti-1375	490	16	-	-	PUNCT
dti-1375	490	17	wide	wide	ADJ
dti-1375	490	18	profiling	profiling	NOUN
dti-1375	490	19	of	of	ADP
dti-1375	490	20	histone	histone	NOUN
dti-1375	490	21	h3	h3	NOUN
dti-1375	490	22	lysine	lysine	NOUN
dti-1375	490	23	4	4	NUM
dti-1375	490	24	and	and	CCONJ
dti-1375	490	25	lysine	lysine	NOUN
dti-1375	490	26	27	27	NUM
dti-1375	490	27	trimethylation	trimethylation	NOUN
dti-1375	490	28	reveals	reveal	VERB
dti-1375	490	29	an	an	DET
dti-1375	490	30	epigenetic	epigenetic	ADJ
dti-1375	490	31	signature	signature	NOUN
dti-1375	490	32	in	in	ADP
dti-1375	490	33	prostate	prostate	NOUN
dti-1375	490	34	carcinogenesis	carcinogenesis	NOUN
dti-1375	490	35	.	.	PUNCT
dti-1375	491	1	plos	plos	PROPN
dti-1375	491	2	one	one	NUM
dti-1375	491	3	.	.	PUNCT
dti-1375	492	1	2009;4	2009;4	NUM
dti-1375	492	2	:	:	PUNCT
dti-1375	492	3	e4687	e4687	NOUN
dti-1375	492	4	.	.	PUNCT
dti-1375	493	1	20	20	NUM
dti-1375	493	2	.	.	PUNCT
dti-1375	494	1	posepelova	posepelova	PROPN
dti-1375	494	2	tv	tv	PROPN
dti-1375	494	3	,	,	PUNCT
dti-1375	494	4	demidenko	demidenko	PROPN
dti-1375	494	5	zn	zn	PROPN
dti-1375	494	6	,	,	PUNCT
dti-1375	494	7	bukreeva	bukreeva	PROPN
dti-1375	494	8	ei	ei	PROPN
dti-1375	494	9	,	,	PUNCT
dti-1375	494	10	pospelov	pospelov	PROPN
dti-1375	494	11	va	va	NOUN
dti-1375	494	12	,	,	PUNCT
dti-1375	494	13	gudkov	gudkov	PROPN
dti-1375	494	14	av	av	PROPN
dti-1375	494	15	,	,	PUNCT
dti-1375	494	16	blagosklonny	blagosklonny	VERB
dti-1375	494	17	mv	mv	PROPN
dti-1375	494	18	.	.	PUNCT
dti-1375	495	1	pseudo	pseudo	NOUN
dti-1375	495	2	-	-	NOUN
dti-1375	495	3	dna	dna	ADJ
dti-1375	495	4	damage	damage	NOUN
dti-1375	495	5	in	in	ADP
dti-1375	495	6	response	response	NOUN
dti-1375	495	7	in	in	ADP
dti-1375	495	8	senescent	senescent	ADJ
dti-1375	495	9	cells	cell	NOUN
dti-1375	495	10	.	.	PUNCT
dti-1375	496	1	cell	cell	NOUN
dti-1375	496	2	cycle	cycle	NOUN
dti-1375	496	3	.	.	PUNCT
dti-1375	497	1	2009;8:4112–8	2009;8:4112–8	X
dti-1375	497	2	.	.	X
dti-1375	498	1	21	21	NUM
dti-1375	498	2	.	.	PUNCT
dti-1375	499	1	beausejour	beausejour	PRON
dti-1375	499	2	cm	cm	PROPN
dti-1375	499	3	,	,	PUNCT
dti-1375	499	4	krtolica	krtolica	PROPN
dti-1375	499	5	a	a	PROPN
dti-1375	499	6	,	,	PUNCT
dti-1375	499	7	galimi	galimi	PROPN
dti-1375	499	8	f	f	PROPN
dti-1375	499	9	,	,	PUNCT
dti-1375	499	10	et	et	PROPN
dti-1375	499	11	al	al	PROPN
dti-1375	499	12	.	.	PROPN
dti-1375	499	13	reversal	reversal	NOUN
dti-1375	499	14	of	of	ADP
dti-1375	499	15	human	human	ADJ
dti-1375	499	16	cellular	cellular	ADJ
dti-1375	499	17	senescence	senescence	NOUN
dti-1375	499	18	:	:	PUNCT
dti-1375	499	19	roles	role	NOUN
dti-1375	499	20	of	of	ADP
dti-1375	499	21	the	the	DET
dti-1375	499	22	p53	p53	NOUN
dti-1375	499	23	and	and	CCONJ
dti-1375	499	24	p16	p16	NOUN
dti-1375	499	25	pathways	pathway	NOUN
dti-1375	499	26	.	.	PUNCT
dti-1375	500	1	embo	embo	PROPN
dti-1375	500	2	j.	j.	PROPN
dti-1375	500	3	2003;22:4212–22	2003;22:4212–22	PROPN
dti-1375	500	4	.	.	PUNCT
dti-1375	501	1	22	22	NUM
dti-1375	501	2	.	.	PUNCT
dti-1375	502	1	omura	omura	NOUN
dti-1375	502	2	-	-	PUNCT
dti-1375	502	3	minamisawa	minamisawa	PROPN
dti-1375	502	4	m	m	PROPN
dti-1375	502	5	,	,	PUNCT
dti-1375	502	6	diccianni	diccianni	PROPN
dti-1375	502	7	mb	mb	PROPN
dti-1375	502	8	,	,	PUNCT
dti-1375	502	9	chang	chang	PROPN
dti-1375	502	10	rc	rc	PROPN
dti-1375	502	11	,	,	PUNCT
dti-1375	502	12	et	et	PROPN
dti-1375	502	13	al	al	PROPN
dti-1375	502	14	.	.	PROPN
dti-1375	502	15	p16	p16	PROPN
dti-1375	502	16	/	/	SYM
dti-1375	502	17	p14(arf	p14(arf	NOUN
dti-1375	502	18	)	)	PUNCT
dti-1375	502	19	cell	cell	NOUN
dti-1375	502	20	cycle	cycle	NOUN
dti-1375	502	21	regulatory	regulatory	ADJ
dti-1375	502	22	pathways	pathway	NOUN
dti-1375	502	23	in	in	ADP
dti-1375	502	24	primary	primary	ADJ
dti-1375	502	25	neuroblastoma	neuroblastoma	NOUN
dti-1375	502	26	:	:	PUNCT
dti-1375	502	27	p16	p16	NOUN
dti-1375	502	28	expression	expression	NOUN
dti-1375	502	29	is	be	AUX
dti-1375	502	30	associated	associate	VERB
dti-1375	502	31	with	with	ADP
dti-1375	502	32	advanced	advanced	ADJ
dti-1375	502	33	stage	stage	NOUN
dti-1375	502	34	disease	disease	NOUN
dti-1375	502	35	.	.	PUNCT
dti-1375	503	1	clin	clin	PROPN
dti-1375	503	2	cancer	cancer	NOUN
dti-1375	503	3	res	re	NOUN
dti-1375	503	4	.	.	PUNCT
dti-1375	504	1	2001;7	2001;7	NUM
dti-1375	504	2	:	:	PUNCT
dti-1375	504	3	3481–90	3481–90	NUM
dti-1375	504	4	.	.	PUNCT
dti-1375	505	1	23	23	NUM
dti-1375	505	2	.	.	PUNCT
dti-1375	506	1	huang	huang	PROPN
dti-1375	506	2	ms	ms	PROPN
dti-1375	506	3	,	,	PUNCT
dti-1375	506	4	adebanjo	adebanjo	NOUN
dti-1375	506	5	oa	oa	PROPN
dti-1375	506	6	,	,	PUNCT
dti-1375	506	7	awumey	awumey	ADJ
dti-1375	506	8	e	e	NOUN
dti-1375	506	9	,	,	PUNCT
dti-1375	506	10	et	et	PROPN
dti-1375	506	11	al	al	PROPN
dti-1375	506	12	.	.	PUNCT
dti-1375	506	13	ip(3	ip(3	PROPN
dti-1375	506	14	)	)	PUNCT
dti-1375	506	15	,	,	PUNCT
dti-1375	506	16	ip(3	ip(3	NOUN
dti-1375	506	17	)	)	PUNCT
dti-1375	506	18	receptor	receptor	NOUN
dti-1375	506	19	,	,	PUNCT
dti-1375	506	20	and	and	CCONJ
dti-1375	506	21	cellular	cellular	ADJ
dti-1375	506	22	senescence	senescence	NOUN
dti-1375	506	23	.	.	PUNCT
dti-1375	506	24	am	be	AUX
dti-1375	506	25	j	j	PROPN
dti-1375	506	26	physiol	physiol	PROPN
dti-1375	506	27	renal	renal	PROPN
dti-1375	506	28	physiol	physiol	PROPN
dti-1375	506	29	.	.	PUNCT
dti-1375	507	1	2000;278	2000;278	NUM
dti-1375	507	2	:	:	PUNCT
dti-1375	508	1	f576–84	f576–84	NOUN
dti-1375	508	2	.	.	PUNCT
dti-1375	509	1	24	24	NUM
dti-1375	509	2	.	.	PUNCT
dti-1375	510	1	beckman	beckman	PROPN
dti-1375	510	2	kb	kb	PROPN
dti-1375	510	3	,	,	PUNCT
dti-1375	510	4	ames	ames	PROPN
dti-1375	510	5	bn	bn	PROPN
dti-1375	510	6	.	.	PUNCT
dti-1375	511	1	the	the	DET
dti-1375	511	2	free	free	ADJ
dti-1375	511	3	radical	radical	ADJ
dti-1375	511	4	theory	theory	NOUN
dti-1375	511	5	of	of	ADP
dti-1375	511	6	aging	age	VERB
dti-1375	511	7	matures	mature	NOUN
dti-1375	511	8	.	.	PUNCT
dti-1375	512	1	physiol	physiol	PROPN
dti-1375	512	2	rev	rev	VERB
dti-1375	512	3	.	.	PUNCT
dti-1375	513	1	1998;8:547–81	1998;8:547–81	NUM
dti-1375	513	2	.	.	PUNCT
dti-1375	513	3	http://www.la-press.com	http://www.la-press.com	X
dti-1375	514	1	sarangi	sarangi	PROPN
dti-1375	514	2	et	et	PROPN
dti-1375	514	3	al	al	PROPN
dti-1375	514	4	36	36	NUM
dti-1375	514	5	drug	drug	NOUN
dti-1375	514	6	target	target	NOUN
dti-1375	514	7	insights	insight	NOUN
dti-1375	514	8	2012:6	2012:6	NUM
dti-1375	514	9	25	25	NUM
dti-1375	514	10	.	.	PUNCT
dti-1375	515	1	vayssier	vayssier	ADV
dti-1375	515	2	-	-	PUNCT
dti-1375	515	3	taussat	taussat	VERB
dti-1375	515	4	m	m	NOUN
dti-1375	515	5	,	,	PUNCT
dti-1375	515	6	kreps	kreps	PROPN
dti-1375	515	7	se	se	ADV
dti-1375	515	8	,	,	PUNCT
dti-1375	515	9	adrie	adrie	PROPN
dti-1375	515	10	c	c	PROPN
dti-1375	515	11	,	,	PUNCT
dti-1375	515	12	ava	ava	PROPN
dti-1375	515	13	jd	jd	PROPN
dti-1375	515	14	,	,	PUNCT
dti-1375	515	15	christiani	christiani	PROPN
dti-1375	515	16	d	d	PROPN
dti-1375	515	17	,	,	PUNCT
dti-1375	515	18	polla	polla	PROPN
dti-1375	515	19	bs	bs	PROPN
dti-1375	515	20	.	.	PROPN
dti-1375	515	21	mitochondrial	mitochondrial	ADJ
dti-1375	515	22	membrane	membrane	NOUN
dti-1375	515	23	potential	potential	NOUN
dti-1375	515	24	:	:	PUNCT
dti-1375	515	25	a	a	DET
dti-1375	515	26	novel	novel	ADJ
dti-1375	515	27	biomarker	biomarker	NOUN
dti-1375	515	28	of	of	ADP
dti-1375	515	29	oxidative	oxidative	ADJ
dti-1375	515	30	environmental	environmental	ADJ
dti-1375	515	31	stress	stress	NOUN
dti-1375	515	32	.	.	PUNCT
dti-1375	516	1	envir	envir	PROPN
dti-1375	516	2	health	health	PROPN
dti-1375	516	3	perspect	perspect	NOUN
dti-1375	516	4	.	.	PUNCT
dti-1375	517	1	2002;110:301–5	2002;110:301–5	X
dti-1375	517	2	.	.	NOUN
dti-1375	518	1	26	26	NUM
dti-1375	518	2	.	.	PUNCT
dti-1375	519	1	sohal	sohal	NOUN
dti-1375	519	2	rs	r	NOUN
dti-1375	519	3	,	,	PUNCT
dti-1375	519	4	weindruch	weindruch	PROPN
dti-1375	519	5	r.	r.	PROPN
dti-1375	519	6	oxidative	oxidative	ADJ
dti-1375	519	7	stress	stress	NOUN
dti-1375	519	8	,	,	PUNCT
dti-1375	519	9	caloric	caloric	NOUN
dti-1375	519	10	restriction	restriction	NOUN
dti-1375	519	11	,	,	PUNCT
dti-1375	519	12	and	and	CCONJ
dti-1375	519	13	aging	aging	NOUN
dti-1375	519	14	.	.	PUNCT
dti-1375	520	1	science	science	NOUN
dti-1375	520	2	.	.	PUNCT
dti-1375	521	1	1996;273:59–63	1996;273:59–63	NUM
dti-1375	521	2	.	.	NOUN
dti-1375	521	3	27	27	NUM
dti-1375	521	4	.	.	PUNCT
dti-1375	522	1	passos	passos	PROPN
dti-1375	522	2	jf	jf	PROPN
dti-1375	522	3	,	,	PUNCT
dti-1375	522	4	von	von	PROPN
dti-1375	522	5	zglinicki	zglinicki	PROPN
dti-1375	522	6	t	t	PROPN
dti-1375	522	7	,	,	PUNCT
dti-1375	522	8	saretzki	saretzki	NOUN
dti-1375	522	9	g.	g.	PROPN
dti-1375	522	10	mitochondrial	mitochondrial	ADJ
dti-1375	522	11	dysfunction	dysfunction	NOUN
dti-1375	522	12	and	and	CCONJ
dti-1375	522	13	cell	cell	NOUN
dti-1375	522	14	senescence	senescence	NOUN
dti-1375	522	15	:	:	PUNCT
dti-1375	522	16	cause	cause	NOUN
dti-1375	522	17	or	or	CCONJ
dti-1375	522	18	consequence	consequence	VERB
dti-1375	522	19	?	?	PUNCT
dti-1375	523	1	rejuvenation	rejuvenation	NOUN
dti-1375	523	2	res	re	NOUN
dti-1375	523	3	.	.	PUNCT
dti-1375	524	1	2006;9:64–8	2006;9:64–8	NUM
dti-1375	524	2	.	.	PUNCT
dti-1375	525	1	28	28	NUM
dti-1375	525	2	.	.	PUNCT
dti-1375	526	1	collado	collado	PROPN
dti-1375	526	2	m	m	PROPN
dti-1375	526	3	,	,	PUNCT
dti-1375	526	4	medema	medema	PROPN
dti-1375	526	5	rene	rene	PROPN
dti-1375	526	6	h	h	PROPN
dti-1375	526	7	,	,	PUNCT
dti-1375	526	8	garcia	garcia	PROPN
dti-1375	526	9	-	-	PUNCT
dti-1375	526	10	cao	cao	PROPN
dti-1375	527	1	i	i	PROPN
dti-1375	527	2	,	,	PUNCT
dti-1375	527	3	et	et	PROPN
dti-1375	527	4	al	al	PROPN
dti-1375	527	5	.	.	PROPN
dti-1375	527	6	inhibition	inhibition	NOUN
dti-1375	527	7	of	of	ADP
dti-1375	527	8	the	the	DET
dti-1375	527	9	phosphoinositide	phosphoinositide	NOUN
dti-1375	527	10	3	3	NUM
dti-1375	527	11	-	-	PUNCT
dti-1375	527	12	kinase	kinase	NOUN
dti-1375	527	13	pathway	pathway	NOUN
dti-1375	527	14	induces	induce	VERB
dti-1375	527	15	a	a	DET
dti-1375	527	16	senescence	senescence	NOUN
dti-1375	527	17	-	-	PUNCT
dti-1375	527	18	like	like	ADJ
dti-1375	527	19	arrest	arrest	NOUN
dti-1375	527	20	mediated	mediate	VERB
dti-1375	527	21	by	by	ADP
dti-1375	527	22	p27kip1	p27kip1	PROPN
dti-1375	527	23	.	.	PUNCT
dti-1375	528	1	j	j	PROPN
dti-1375	528	2	biol	biol	PROPN
dti-1375	528	3	chem	chem	NOUN
dti-1375	528	4	.	.	PUNCT
dti-1375	529	1	2000;275:21960–8	2000;275:21960–8	NOUN
dti-1375	529	2	.	.	PROPN
dti-1375	530	1	29	29	NUM
dti-1375	530	2	.	.	PUNCT
dti-1375	530	3	achuthan	achuthan	PROPN
dti-1375	530	4	s	s	PROPN
dti-1375	530	5	,	,	PUNCT
dti-1375	530	6	santhoshkumar	santhoshkumar	NOUN
dti-1375	530	7	tr	tr	VERB
dti-1375	530	8	,	,	PUNCT
dti-1375	530	9	prabhakar	prabhakar	PROPN
dti-1375	530	10	j	j	PROPN
dti-1375	530	11	,	,	PUNCT
dti-1375	530	12	nair	nair	PROPN
dti-1375	530	13	sa	sa	PROPN
dti-1375	530	14	,	,	PUNCT
dti-1375	530	15	pillai	pillai	PROPN
dti-1375	530	16	mr	mr	PROPN
dti-1375	530	17	.	.	PROPN
dti-1375	530	18	drug	drug	NOUN
dti-1375	530	19	-	-	PUNCT
dti-1375	530	20	induced	induce	VERB
dti-1375	530	21	senescence	senescence	NOUN
dti-1375	530	22	generates	generate	VERB
dti-1375	530	23	chemoresistant	chemoresistant	ADJ
dti-1375	530	24	stemlike	stemlike	ADJ
dti-1375	530	25	cells	cell	NOUN
dti-1375	530	26	with	with	ADP
dti-1375	530	27	low	low	ADJ
dti-1375	530	28	reactive	reactive	ADJ
dti-1375	530	29	oxygen	oxygen	NOUN
dti-1375	530	30	species	specie	NOUN
dti-1375	530	31	.	.	PUNCT
dti-1375	531	1	j	j	PROPN
dti-1375	531	2	biol	biol	PROPN
dti-1375	531	3	chem	chem	NOUN
dti-1375	531	4	.	.	PUNCT
dti-1375	532	1	2011;286:37813–29	2011;286:37813–29	NOUN
dti-1375	532	2	.	.	PUNCT
dti-1375	533	1	30	30	NUM
dti-1375	533	2	.	.	PUNCT
dti-1375	534	1	ewald	ewald	PROPN
dti-1375	534	2	ja	ja	PROPN
dti-1375	534	3	,	,	PUNCT
dti-1375	534	4	desotelle	desotelle	PROPN
dti-1375	534	5	ja	ja	PROPN
dti-1375	534	6	,	,	PUNCT
dti-1375	534	7	wilding	wilde	VERB
dti-1375	534	8	g	g	NOUN
dti-1375	534	9	,	,	PUNCT
dti-1375	534	10	jarrard	jarrard	NOUN
dti-1375	534	11	df	df	PROPN
dti-1375	534	12	.	.	PUNCT
dti-1375	535	1	therapy	therapy	NOUN
dti-1375	535	2	-	-	PUNCT
dti-1375	535	3	induced	induce	VERB
dti-1375	535	4	senescence	senescence	NOUN
dti-1375	535	5	in	in	ADP
dti-1375	535	6	cancer	cancer	NOUN
dti-1375	535	7	.	.	PUNCT
dti-1375	536	1	j	j	PROPN
dti-1375	536	2	natl	natl	PROPN
dti-1375	536	3	cancer	cancer	PROPN
dti-1375	536	4	inst	inst	PROPN
dti-1375	536	5	.	.	PUNCT
dti-1375	537	1	2010;102:1536–46	2010;102:1536–46	NUM
dti-1375	537	2	.	.	PUNCT
dti-1375	538	1	31	31	NUM
dti-1375	538	2	.	.	PUNCT
dti-1375	539	1	michishita	michishita	PROPN
dti-1375	539	2	e	e	PROPN
dti-1375	539	3	,	,	PUNCT
dti-1375	539	4	nakabayashi	nakabayashi	PROPN
dti-1375	539	5	k	k	PROPN
dti-1375	539	6	,	,	PUNCT
dti-1375	539	7	ogino	ogino	PROPN
dti-1375	539	8	h	h	PROPN
dti-1375	539	9	,	,	PUNCT
dti-1375	539	10	suzuki	suzuki	PROPN
dti-1375	539	11	t	t	PROPN
dti-1375	539	12	,	,	PUNCT
dti-1375	539	13	fujii	fujii	PROPN
dti-1375	539	14	m	m	PROPN
dti-1375	539	15	,	,	PUNCT
dti-1375	539	16	ayusawa	ayusawa	PROPN
dti-1375	539	17	d.	d.	PROPN
dti-1375	539	18	dna	dna	PROPN
dti-1375	539	19	topoisomerase	topoisomerase	VERB
dti-1375	539	20	inhibitors	inhibitor	NOUN
dti-1375	539	21	induce	induce	VERB
dti-1375	539	22	reversible	reversible	ADJ
dti-1375	539	23	senescence	senescence	NOUN
dti-1375	539	24	in	in	ADP
dti-1375	539	25	normal	normal	ADJ
dti-1375	539	26	human	human	ADJ
dti-1375	539	27	fibroblasts	fibroblast	NOUN
dti-1375	539	28	.	.	PUNCT
dti-1375	540	1	biochem	biochem	PROPN
dti-1375	540	2	biophys	biophy	NOUN
dti-1375	540	3	res	re	NOUN
dti-1375	540	4	comm	comm	NOUN
dti-1375	540	5	.	.	PUNCT
dti-1375	541	1	1998;253:667–71	1998;253:667–71	NOUN
dti-1375	541	2	.	.	PUNCT
dti-1375	542	1	32	32	NUM
dti-1375	542	2	.	.	PUNCT
dti-1375	543	1	kamal	kamal	PROPN
dti-1375	543	2	a	a	PROPN
dti-1375	543	3	,	,	PUNCT
dti-1375	543	4	thao	thao	PROPN
dti-1375	543	5	l	l	PROPN
dti-1375	543	6	,	,	PUNCT
dti-1375	543	7	sensintaffar	sensintaffar	PROPN
dti-1375	543	8	j	j	PROPN
dti-1375	543	9	,	,	PUNCT
dti-1375	543	10	et	et	PROPN
dti-1375	543	11	al	al	PROPN
dti-1375	543	12	.	.	PUNCT
dti-1375	544	1	a	a	DET
dti-1375	544	2	high	high	ADJ
dti-1375	544	3	-	-	PUNCT
dti-1375	544	4	affinity	affinity	NOUN
dti-1375	544	5	conformation	conformation	NOUN
dti-1375	544	6	of	of	ADP
dti-1375	544	7	hsp90	hsp90	ADJ
dti-1375	544	8	confers	confer	NOUN
dti-1375	544	9	tumour	tumour	NOUN
dti-1375	544	10	selectivity	selectivity	NOUN
dti-1375	544	11	on	on	ADP
dti-1375	544	12	hsp90	hsp90	ADJ
dti-1375	544	13	inhibitors	inhibitor	NOUN
dti-1375	544	14	.	.	PUNCT
dti-1375	545	1	nature	nature	NOUN
dti-1375	545	2	.	.	PUNCT
dti-1375	546	1	2003;425:407–10	2003;425:407–10	X
dti-1375	546	2	.	.	PUNCT
dti-1375	547	1	33	33	NUM
dti-1375	547	2	.	.	PUNCT
dti-1375	548	1	csermely	csermely	ADV
dti-1375	548	2	p	p	X
dti-1375	548	3	,	,	PUNCT
dti-1375	548	4	schnaider	schnaider	PROPN
dti-1375	548	5	t	t	PROPN
dti-1375	548	6	,	,	PUNCT
dti-1375	548	7	soti	soti	NOUN
dti-1375	548	8	c	c	NOUN
dti-1375	548	9	,	,	PUNCT
dti-1375	548	10	pohaszka	pohaszka	PROPN
dti-1375	548	11	z	z	PROPN
dti-1375	548	12	,	,	PUNCT
dti-1375	548	13	nardai	nardai	PROPN
dti-1375	549	1	g.	g.	PROPN
dti-1375	550	1	the	the	DET
dti-1375	550	2	90	90	NUM
dti-1375	550	3	-	-	PUNCT
dti-1375	550	4	kda	kda	NOUN
dti-1375	550	5	molecular	molecular	ADJ
dti-1375	550	6	chaperone	chaperone	NOUN
dti-1375	550	7	family	family	NOUN
dti-1375	550	8	:	:	PUNCT
dti-1375	550	9	structure	structure	NOUN
dti-1375	550	10	,	,	PUNCT
dti-1375	550	11	function	function	NOUN
dti-1375	550	12	,	,	PUNCT
dti-1375	550	13	and	and	CCONJ
dti-1375	550	14	clinical	clinical	ADJ
dti-1375	550	15	applications	application	NOUN
dti-1375	550	16	.	.	PUNCT
dti-1375	551	1	a	a	DET
dti-1375	551	2	comprehensive	comprehensive	ADJ
dti-1375	551	3	review	review	NOUN
dti-1375	551	4	.	.	PUNCT
dti-1375	552	1	pharmacol	pharmacol	VERB
dti-1375	552	2	ther	ther	ADV
dti-1375	552	3	.	.	PUNCT
dti-1375	553	1	1998;79:129–68	1998;79:129–68	X
dti-1375	553	2	.	.	PUNCT
dti-1375	554	1	34	34	NUM
dti-1375	554	2	.	.	PUNCT
dti-1375	555	1	coppe	coppe	PROPN
dti-1375	555	2	jp	jp	PROPN
dti-1375	555	3	,	,	PUNCT
dti-1375	555	4	desprez	desprez	PROPN
dti-1375	555	5	py	py	PROPN
dti-1375	555	6	,	,	PUNCT
dti-1375	555	7	krtolica	krtolica	PROPN
dti-1375	555	8	a	a	PROPN
dti-1375	555	9	,	,	PUNCT
dti-1375	555	10	campisi	campisi	PROPN
dti-1375	555	11	j.	j.	PROPN
dti-1375	555	12	the	the	DET
dti-1375	555	13	senescence	senescence	NOUN
dti-1375	555	14	-	-	PUNCT
dti-1375	555	15	associated	associate	VERB
dti-1375	555	16	secretory	secretory	ADJ
dti-1375	555	17	phenotype	phenotype	NOUN
dti-1375	555	18	:	:	PUNCT
dti-1375	555	19	the	the	DET
dti-1375	555	20	dark	dark	ADJ
dti-1375	555	21	side	side	NOUN
dti-1375	555	22	of	of	ADP
dti-1375	555	23	tumor	tumor	NOUN
dti-1375	555	24	suppression	suppression	NOUN
dti-1375	555	25	.	.	PUNCT
dti-1375	556	1	annu	annu	PROPN
dti-1375	556	2	rev	rev	PROPN
dti-1375	556	3	pathol	pathol	PROPN
dti-1375	556	4	2010;5:99–118	2010;5:99–118	NUM
dti-1375	556	5	.	.	PROPN
dti-1375	556	6	35	35	NUM
dti-1375	556	7	.	.	PUNCT
dti-1375	557	1	coppe	coppe	PROPN
dti-1375	557	2	jp	jp	PROPN
dti-1375	557	3	,	,	PUNCT
dti-1375	557	4	patil	patil	PROPN
dti-1375	557	5	ck	ck	PROPN
dti-1375	557	6	,	,	PUNCT
dti-1375	557	7	rodier	rodi	ADJ
dti-1375	557	8	f	f	PROPN
dti-1375	557	9	,	,	PUNCT
dti-1375	557	10	et	et	PROPN
dti-1375	557	11	al	al	PROPN
dti-1375	557	12	.	.	PUNCT
dti-1375	557	13	senescence	senescence	NOUN
dti-1375	557	14	-	-	PUNCT
dti-1375	557	15	associated	associate	VERB
dti-1375	557	16	secretory	secretory	ADJ
dti-1375	557	17	phenotypes	phenotype	NOUN
dti-1375	557	18	reveal	reveal	VERB
dti-1375	557	19	cell	cell	NOUN
dti-1375	557	20	-	-	PUNCT
dti-1375	557	21	nonautonomous	nonautonomous	ADJ
dti-1375	557	22	functions	function	NOUN
dti-1375	557	23	of	of	ADP
dti-1375	557	24	oncogenic	oncogenic	NOUN
dti-1375	557	25	ras	ras	PROPN
dti-1375	557	26	and	and	CCONJ
dti-1375	557	27	the	the	DET
dti-1375	557	28	p53	p53	NOUN
dti-1375	557	29	tumor	tumor	NOUN
dti-1375	557	30	suppressor	suppressor	NOUN
dti-1375	557	31	.	.	PUNCT
dti-1375	558	1	plos	plos	PROPN
dti-1375	558	2	biol	biol	PROPN
dti-1375	558	3	.	.	PUNCT
dti-1375	559	1	2008;6:2853–68	2008;6:2853–68	NOUN
dti-1375	559	2	.	.	X
dti-1375	560	1	36	36	NUM
dti-1375	560	2	.	.	PUNCT
dti-1375	561	1	maris	maris	PROPN
dti-1375	561	2	jm	jm	PROPN
dti-1375	561	3	.	.	PROPN
dti-1375	562	1	recent	recent	ADJ
dti-1375	562	2	advances	advance	NOUN
dti-1375	562	3	in	in	ADP
dti-1375	562	4	neuroblastoma	neuroblastoma	NOUN
dti-1375	562	5	.	.	PUNCT
dti-1375	563	1	n	n	CCONJ
dti-1375	563	2	engl	engl	PROPN
dti-1375	563	3	j	j	PROPN
dti-1375	563	4	med	med	PROPN
dti-1375	563	5	.	.	PUNCT
dti-1375	564	1	2010;362	2010;362	NUM
dti-1375	564	2	:	:	PUNCT
dti-1375	565	1	2202–11	2202–11	NUM
dti-1375	565	2	.	.	PUNCT
dti-1375	566	1	37	37	NUM
dti-1375	566	2	.	.	PUNCT
dti-1375	567	1	jyhothi	jyhothi	PROPN
dti-1375	568	1	d	d	PROPN
dti-1375	568	2	,	,	PUNCT
dti-1375	568	3	vanathi	vanathi	PROPN
dti-1375	568	4	p	p	PROPN
dti-1375	568	5	,	,	PUNCT
dti-1375	568	6	mangala	mangala	PROPN
dti-1375	568	7	gowri	gowri	PROPN
dti-1375	568	8	o	o	PROPN
dti-1375	568	9	,	,	PUNCT
dti-1375	568	10	rama	rama	PROPN
dti-1375	568	11	subba	subba	PROPN
dti-1375	568	12	rao	rao	PROPN
dti-1375	568	13	v	v	PROPN
dti-1375	568	14	,	,	PUNCT
dti-1375	568	15	madhusudhan	madhusudhan	PROPN
dti-1375	568	16	rao	rao	PROPN
dti-1375	568	17	j	j	PROPN
dti-1375	568	18	,	,	PUNCT
dti-1375	568	19	sreedhar	sreedhar	ADJ
dti-1375	568	20	as	as	ADP
dti-1375	568	21	.	.	PUNCT
dti-1375	569	1	diferuloylmethane	diferuloylmethane	PROPN
dti-1375	569	2	augments	augment	VERB
dti-1375	569	3	the	the	DET
dti-1375	569	4	cytotoxic	cytotoxic	ADJ
dti-1375	569	5	effects	effect	NOUN
dti-1375	569	6	of	of	ADP
dti-1375	569	7	piplartine	piplartine	NOUN
dti-1375	569	8	isolated	isolate	VERB
dti-1375	569	9	from	from	ADP
dti-1375	569	10	piper	piper	NOUN
dti-1375	569	11	chaba	chaba	PROPN
dti-1375	569	12	.	.	PUNCT
dti-1375	570	1	toxicol	toxicol	PROPN
dti-1375	570	2	in	in	ADP
dti-1375	570	3	vitro	vitro	X
dti-1375	570	4	.	.	PUNCT
dti-1375	571	1	2009;23:1085–91	2009;23:1085–91	NUM
dti-1375	571	2	.	.	PUNCT
dti-1375	572	1	38	38	NUM
dti-1375	572	2	.	.	PUNCT
dti-1375	573	1	kamal	kamal	PROPN
dti-1375	573	2	a	a	PROPN
dti-1375	573	3	,	,	PUNCT
dti-1375	573	4	burrows	burrow	VERB
dti-1375	573	5	fj	fj	INTJ
dti-1375	573	6	.	.	PUNCT
dti-1375	574	1	hsp90	hsp90	ADJ
dti-1375	574	2	inhibitors	inhibitor	NOUN
dti-1375	574	3	as	as	ADP
dti-1375	574	4	selective	selective	ADJ
dti-1375	574	5	anticancer	anticancer	NOUN
dti-1375	574	6	drugs	drug	NOUN
dti-1375	574	7	.	.	PUNCT
dti-1375	575	1	discov	discov	PROPN
dti-1375	575	2	med	med	PROPN
dti-1375	575	3	.	.	PUNCT
dti-1375	576	1	2004;4:277–80	2004;4:277–80	NOUN
dti-1375	576	2	.	.	NOUN
dti-1375	576	3	39	39	NUM
dti-1375	576	4	.	.	PUNCT
dti-1375	577	1	sreedhar	sreedhar	NOUN
dti-1375	577	2	as	as	ADP
dti-1375	577	3	,	,	PUNCT
dti-1375	577	4	mihaly	mihaly	PROPN
dti-1375	577	5	k	k	PROPN
dti-1375	577	6	,	,	PUNCT
dti-1375	577	7	pato	pato	PROPN
dti-1375	577	8	b	b	X
dti-1375	577	9	,	,	PUNCT
dti-1375	577	10	et	et	PROPN
dti-1375	577	11	al	al	PROPN
dti-1375	577	12	.	.	PUNCT
dti-1375	578	1	hsp90	hsp90	ADJ
dti-1375	578	2	inhibition	inhibition	NOUN
dti-1375	578	3	accelerates	accelerate	VERB
dti-1375	578	4	cell	cell	NOUN
dti-1375	578	5	lysis	lysis	NOUN
dti-1375	578	6	:	:	PUNCT
dti-1375	578	7	anti	anti	ADJ
dti-1375	578	8	-	-	ADJ
dti-1375	578	9	hsp90	hsp90	ADJ
dti-1375	578	10	ribozyme	ribozyme	NOUN
dti-1375	578	11	reveals	reveal	VERB
dti-1375	578	12	a	a	DET
dti-1375	578	13	complex	complex	ADJ
dti-1375	578	14	mechanism	mechanism	NOUN
dti-1375	578	15	of	of	ADP
dti-1375	578	16	hsp90	hsp90	ADJ
dti-1375	578	17	inhibitors	inhibitor	NOUN
dti-1375	578	18	involving	involve	VERB
dti-1375	578	19	both	both	PRON
dti-1375	578	20	superoxidesand	superoxidesand	ADJ
dti-1375	578	21	hsp90	hsp90	VERB
dti-1375	578	22	-	-	PUNCT
dti-1375	578	23	dependent	dependent	ADJ
dti-1375	578	24	events	event	NOUN
dti-1375	578	25	.	.	PUNCT
dti-1375	579	1	j	j	PROPN
dti-1375	579	2	biol	biol	PROPN
dti-1375	579	3	chem	chem	NOUN
dti-1375	579	4	.	.	PUNCT
dti-1375	580	1	2003;278:35231–40	2003;278:35231–40	NUM
dti-1375	580	2	.	.	PROPN
dti-1375	581	1	40	40	NUM
dti-1375	581	2	.	.	PUNCT
dti-1375	581	3	di	di	NOUN
dti-1375	581	4	micco	micco	PROPN
dti-1375	581	5	r	r	PROPN
dti-1375	581	6	,	,	PUNCT
dti-1375	581	7	sulli	sulli	PROPN
dti-1375	581	8	g	g	PROPN
dti-1375	581	9	,	,	PUNCT
dti-1375	581	10	dobreva	dobreva	PROPN
dti-1375	581	11	m	m	PROPN
dti-1375	581	12	,	,	PUNCT
dti-1375	581	13	et	et	PROPN
dti-1375	581	14	al	al	PROPN
dti-1375	581	15	.	.	PROPN
dti-1375	581	16	interplay	interplay	NOUN
dti-1375	581	17	between	between	ADP
dti-1375	581	18	oncogene	oncogene	NOUN
dti-1375	581	19	-	-	PUNCT
dti-1375	581	20	induced	induce	VERB
dti-1375	581	21	dna	dna	PROPN
dti-1375	581	22	damage	damage	NOUN
dti-1375	581	23	response	response	NOUN
dti-1375	581	24	and	and	CCONJ
dti-1375	581	25	heterochromatin	heterochromatin	NOUN
dti-1375	581	26	in	in	ADP
dti-1375	581	27	senescence	senescence	NOUN
dti-1375	581	28	and	and	CCONJ
dti-1375	581	29	cancer	cancer	NOUN
dti-1375	581	30	.	.	PUNCT
dti-1375	582	1	nat	nat	NOUN
dti-1375	582	2	cell	cell	NOUN
dti-1375	582	3	biol	biol	PROPN
dti-1375	582	4	.	.	PUNCT
dti-1375	583	1	2011;13:292–302	2011;13:292–302	NUM
dti-1375	583	2	.	.	PUNCT
dti-1375	584	1	41	41	NUM
dti-1375	584	2	.	.	PUNCT
dti-1375	585	1	spallarossa	spallarossa	PROPN
dti-1375	585	2	p	p	PROPN
dti-1375	585	3	,	,	PUNCT
dti-1375	585	4	altieri	altieri	PROPN
dti-1375	585	5	p	p	PROPN
dti-1375	585	6	,	,	PUNCT
dti-1375	585	7	aloi	aloi	PROPN
dti-1375	585	8	c	c	PROPN
dti-1375	585	9	,	,	PUNCT
dti-1375	585	10	et	et	PROPN
dti-1375	585	11	al	al	PROPN
dti-1375	585	12	.	.	PUNCT
dti-1375	586	1	doxorubicin	doxorubicin	PROPN
dti-1375	586	2	induces	induce	VERB
dti-1375	586	3	senescence	senescence	NOUN
dti-1375	586	4	or	or	CCONJ
dti-1375	586	5	apoptosis	apoptosis	NOUN
dti-1375	586	6	in	in	ADP
dti-1375	586	7	rat	rat	NOUN
dti-1375	586	8	neonatal	neonatal	ADJ
dti-1375	586	9	cardiomyocytes	cardiomyocyte	NOUN
dti-1375	586	10	by	by	ADP
dti-1375	586	11	regulating	regulate	VERB
dti-1375	586	12	the	the	DET
dti-1375	586	13	expression	expression	NOUN
dti-1375	586	14	levels	level	NOUN
dti-1375	586	15	of	of	ADP
dti-1375	586	16	the	the	DET
dti-1375	586	17	telomere	telomere	NOUN
dti-1375	586	18	binding	bind	VERB
dti-1375	586	19	factors	factor	NOUN
dti-1375	586	20	1	1	NUM
dti-1375	586	21	and	and	CCONJ
dti-1375	586	22	2	2	NUM
dti-1375	586	23	.	.	X
dti-1375	586	24	am	be	AUX
dti-1375	586	25	j	j	PROPN
dti-1375	586	26	physiol	physiol	PROPN
dti-1375	586	27	heart	heart	PROPN
dti-1375	586	28	circ	circ	PROPN
dti-1375	586	29	physiol	physiol	PROPN
dti-1375	586	30	.	.	PUNCT
dti-1375	587	1	2009;297	2009;297	NUM
dti-1375	587	2	:	:	PUNCT
dti-1375	587	3	h2169–81	h2169–81	ADJ
dti-1375	587	4	.	.	X
dti-1375	587	5	42	42	NUM
dti-1375	587	6	.	.	PUNCT
dti-1375	588	1	aprelikova	aprelikova	PROPN
dti-1375	589	1	o	o	NOUN
dti-1375	589	2	,	,	PUNCT
dti-1375	589	3	xiong	xiong	PROPN
dti-1375	589	4	y	y	PROPN
dti-1375	589	5	,	,	PUNCT
dti-1375	589	6	liu	liu	PROPN
dti-1375	589	7	et	et	PROPN
dti-1375	589	8	.	.	PUNCT
dti-1375	590	1	both	both	DET
dti-1375	590	2	p16	p16	NOUN
dti-1375	590	3	and	and	CCONJ
dti-1375	590	4	p21	p21	NOUN
dti-1375	590	5	families	family	NOUN
dti-1375	590	6	of	of	ADP
dti-1375	590	7	cyclin	cyclin	NOUN
dti-1375	590	8	-	-	PUNCT
dti-1375	590	9	dependent	dependent	ADJ
dti-1375	590	10	kinase	kinase	NOUN
dti-1375	590	11	(	(	PUNCT
dti-1375	590	12	cdk	cdk	PROPN
dti-1375	590	13	)	)	PUNCT
dti-1375	590	14	inhibitors	inhibitor	NOUN
dti-1375	590	15	block	block	VERB
dti-1375	590	16	the	the	DET
dti-1375	590	17	phosphorylation	phosphorylation	NOUN
dti-1375	590	18	of	of	ADP
dti-1375	590	19	cyclin	cyclin	NOUN
dti-1375	590	20	-	-	PUNCT
dti-1375	590	21	dependent	dependent	ADJ
dti-1375	590	22	kinases	kinase	NOUN
dti-1375	590	23	by	by	ADP
dti-1375	590	24	the	the	DET
dti-1375	590	25	cdk	cdk	PROPN
dti-1375	590	26	-	-	PUNCT
dti-1375	590	27	activating	activate	VERB
dti-1375	590	28	kinase	kinase	NOUN
dti-1375	590	29	.	.	PUNCT
dti-1375	591	1	j	j	PROPN
dti-1375	591	2	biol	biol	PROPN
dti-1375	591	3	chem	chem	NOUN
dti-1375	591	4	.	.	PUNCT
dti-1375	592	1	1995;270:18195–7	1995;270:18195–7	NUM
dti-1375	592	2	.	.	PUNCT
dti-1375	593	1	43	43	NUM
dti-1375	593	2	.	.	PUNCT
dti-1375	594	1	romagosa	romagosa	PROPN
dti-1375	594	2	c	c	PROPN
dti-1375	594	3	,	,	PUNCT
dti-1375	594	4	simonetti	simonetti	PROPN
dti-1375	594	5	s	s	PROPN
dti-1375	594	6	,	,	PUNCT
dti-1375	594	7	lopez	lopez	NOUN
dti-1375	594	8	-	-	PUNCT
dti-1375	594	9	vicente	vicente	PROPN
dti-1375	594	10	l	l	PROPN
dti-1375	594	11	,	,	PUNCT
dti-1375	594	12	et	et	PROPN
dti-1375	594	13	al	al	PROPN
dti-1375	594	14	.	.	PUNCT
dti-1375	595	1	p16(ink4a	p16(ink4a	PROPN
dti-1375	595	2	)	)	PUNCT
dti-1375	596	1	overexpression	overexpression	NOUN
dti-1375	596	2	in	in	ADP
dti-1375	596	3	cancer	cancer	NOUN
dti-1375	596	4	:	:	PUNCT
dti-1375	596	5	a	a	DET
dti-1375	596	6	tumor	tumor	NOUN
dti-1375	596	7	suppressor	suppressor	NOUN
dti-1375	596	8	gene	gene	NOUN
dti-1375	596	9	associated	associate	VERB
dti-1375	596	10	with	with	ADP
dti-1375	596	11	senescence	senescence	NOUN
dti-1375	596	12	and	and	CCONJ
dti-1375	596	13	high	high	ADJ
dti-1375	596	14	-	-	PUNCT
dti-1375	596	15	grade	grade	NOUN
dti-1375	596	16	tumors	tumor	NOUN
dti-1375	596	17	.	.	PUNCT
dti-1375	597	1	oncogene	oncogene	NOUN
dti-1375	597	2	.	.	PUNCT
dti-1375	598	1	2011;30:2087–97	2011;30:2087–97	NUM
dti-1375	598	2	.	.	X
dti-1375	599	1	44	44	NUM
dti-1375	599	2	.	.	PUNCT
dti-1375	600	1	restall	restall	NOUN
dti-1375	600	2	ij	ij	NOUN
dti-1375	600	3	,	,	PUNCT
dti-1375	600	4	lorimer	lorimer	PROPN
dti-1375	600	5	ia	ia	PROPN
dti-1375	600	6	.	.	PROPN
dti-1375	600	7	induction	induction	NOUN
dti-1375	600	8	of	of	ADP
dti-1375	600	9	premature	premature	ADJ
dti-1375	600	10	senescence	senescence	NOUN
dti-1375	600	11	by	by	ADP
dti-1375	600	12	hsp90	hsp90	ADJ
dti-1375	600	13	inhibition	inhibition	NOUN
dti-1375	600	14	in	in	ADP
dti-1375	600	15	small	small	ADJ
dti-1375	600	16	cell	cell	NOUN
dti-1375	600	17	lung	lung	NOUN
dti-1375	600	18	cancer	cancer	NOUN
dti-1375	600	19	.	.	PUNCT
dti-1375	601	1	plos	plos	PROPN
dti-1375	601	2	one	one	NUM
dti-1375	601	3	.	.	PUNCT
dti-1375	602	1	2010;5	2010;5	NUM
dti-1375	602	2	:	:	PUNCT
dti-1375	602	3	e11072	e11072	NOUN
dti-1375	602	4	.	.	PROPN
dti-1375	602	5	45	45	NUM
dti-1375	602	6	.	.	PUNCT
dti-1375	603	1	dote	dote	VERB
dti-1375	603	2	h	h	NOUN
dti-1375	603	3	,	,	PUNCT
dti-1375	603	4	burgan	burgan	VERB
dti-1375	603	5	we	we	PRON
dti-1375	603	6	,	,	PUNCT
dti-1375	603	7	camphausen	camphausen	VERB
dti-1375	603	8	k	k	PROPN
dti-1375	603	9	,	,	PUNCT
dti-1375	603	10	tofilon	tofilon	PROPN
dti-1375	603	11	pj	pj	PROPN
dti-1375	603	12	.	.	PROPN
dti-1375	604	1	inhibition	inhibition	NOUN
dti-1375	604	2	of	of	ADP
dti-1375	604	3	hsp90	hsp90	PROPN
dti-1375	604	4	compromises	compromise	VERB
dti-1375	604	5	the	the	DET
dti-1375	604	6	dna	dna	PROPN
dti-1375	604	7	damage	damage	NOUN
dti-1375	604	8	response	response	NOUN
dti-1375	604	9	to	to	ADP
dti-1375	604	10	radiation	radiation	NOUN
dti-1375	604	11	.	.	PUNCT
dti-1375	605	1	cancer	cancer	NOUN
dti-1375	605	2	res	re	NOUN
dti-1375	605	3	.	.	PUNCT
dti-1375	606	1	2006;66	2006;66	NUM
dti-1375	606	2	:	:	PUNCT
dti-1375	606	3	9211–20	9211–20	NUM
dti-1375	606	4	.	.	PUNCT
dti-1375	607	1	46	46	NUM
dti-1375	607	2	.	.	PUNCT
dti-1375	608	1	ha	ha	INTJ
dti-1375	609	1	k	k	NOUN
dti-1375	609	2	,	,	PUNCT
dti-1375	609	3	fiskus	fiskus	VERB
dti-1375	609	4	w	w	PROPN
dti-1375	609	5	,	,	PUNCT
dti-1375	609	6	rao	rao	NOUN
dti-1375	609	7	r	r	NOUN
dti-1375	609	8	,	,	PUNCT
dti-1375	609	9	et	et	PROPN
dti-1375	609	10	al	al	PROPN
dti-1375	609	11	.	.	PUNCT
dti-1375	610	1	hsp90	hsp90	ADJ
dti-1375	610	2	inhibitor	inhibitor	NOUN
dti-1375	610	3	-	-	PUNCT
dti-1375	610	4	mediated	mediate	VERB
dti-1375	610	5	disruption	disruption	NOUN
dti-1375	610	6	of	of	ADP
dti-1375	610	7	chaperone	chaperone	NOUN
dti-1375	610	8	association	association	NOUN
dti-1375	610	9	of	of	ADP
dti-1375	610	10	atr	atr	PROPN
dti-1375	610	11	with	with	ADP
dti-1375	610	12	hsp90	hsp90	PROPN
dti-1375	610	13	sensitizes	sensitize	NOUN
dti-1375	610	14	cancer	cancer	NOUN
dti-1375	610	15	cells	cell	NOUN
dti-1375	610	16	to	to	ADP
dti-1375	610	17	dna	dna	PROPN
dti-1375	610	18	damage	damage	NOUN
dti-1375	610	19	.	.	PUNCT
dti-1375	611	1	mol	mol	ADP
dti-1375	611	2	cancer	cancer	NOUN
dti-1375	611	3	ther	ther	ADV
dti-1375	611	4	.	.	PUNCT
dti-1375	612	1	2011;10:1194–206	2011;10:1194–206	X
dti-1375	612	2	.	.	PROPN
dti-1375	613	1	47	47	NUM
dti-1375	613	2	.	.	PUNCT
dti-1375	614	1	barski	barski	PROPN
dti-1375	614	2	a	a	PROPN
dti-1375	614	3	,	,	PUNCT
dti-1375	614	4	cuddapah	cuddapah	NOUN
dti-1375	614	5	s	s	NOUN
dti-1375	614	6	,	,	PUNCT
dti-1375	614	7	cui	cui	PROPN
dti-1375	614	8	k	k	NOUN
dti-1375	614	9	,	,	PUNCT
dti-1375	614	10	et	et	PROPN
dti-1375	614	11	al	al	PROPN
dti-1375	614	12	.	.	PROPN
dti-1375	614	13	high	high	ADJ
dti-1375	614	14	-	-	PUNCT
dti-1375	614	15	resolution	resolution	NOUN
dti-1375	614	16	profiling	profiling	NOUN
dti-1375	614	17	of	of	ADP
dti-1375	614	18	histone	histone	NOUN
dti-1375	614	19	methylations	methylation	NOUN
dti-1375	614	20	in	in	ADP
dti-1375	614	21	the	the	DET
dti-1375	614	22	human	human	ADJ
dti-1375	614	23	genome	genome	NOUN
dti-1375	614	24	.	.	PUNCT
dti-1375	615	1	cell	cell	NOUN
dti-1375	615	2	.	.	PUNCT
dti-1375	616	1	2007;129:823–37	2007;129:823–37	NUM
dti-1375	616	2	.	.	PUNCT
dti-1375	617	1	48	48	NUM
dti-1375	617	2	.	.	PUNCT
dti-1375	618	1	noor	noor	PROPN
dti-1375	618	2	r	r	PROPN
dti-1375	618	3	,	,	PUNCT
dti-1375	618	4	mittal	mittal	PROPN
dti-1375	618	5	,	,	PUNCT
dti-1375	618	6	s	s	PROPN
dti-1375	618	7	,	,	PUNCT
dti-1375	618	8	iqbal	iqbal	PROPN
dti-1375	618	9	j.	j.	PROPN
dti-1375	618	10	superoxide	superoxide	PROPN
dti-1375	618	11	dismutase	dismutase	NOUN
dti-1375	618	12	—	—	PUNCT
dti-1375	618	13	applications	application	NOUN
dti-1375	618	14	and	and	CCONJ
dti-1375	618	15	relevance	relevance	NOUN
dti-1375	618	16	to	to	ADP
dti-1375	618	17	human	human	ADJ
dti-1375	618	18	diseases	disease	NOUN
dti-1375	618	19	.	.	PUNCT
dti-1375	619	1	med	med	PROPN
dti-1375	619	2	sci	sci	PROPN
dti-1375	619	3	monit	monit	PROPN
dti-1375	619	4	.	.	PUNCT
dti-1375	620	1	2002;8	2002;8	NUM
dti-1375	620	2	:	:	PUNCT
dti-1375	620	3	ra210–05	ra210–05	PROPN
dti-1375	620	4	.	.	PUNCT
dti-1375	621	1	49	49	NUM
dti-1375	621	2	.	.	PUNCT
dti-1375	622	1	dery	dery	PROPN
dti-1375	622	2	e	e	PROPN
dti-1375	622	3	,	,	PUNCT
dti-1375	622	4	gosselin	gosselin	PROPN
dti-1375	622	5	k	k	PROPN
dti-1375	622	6	,	,	PUNCT
dti-1375	622	7	vercamer	vercamer	PROPN
dti-1375	622	8	c	c	NOUN
dti-1375	622	9	,	,	PUNCT
dti-1375	622	10	et	et	PROPN
dti-1375	622	11	al	al	PROPN
dti-1375	622	12	.	.	PROPN
dti-1375	622	13	mnsod	mnsod	PROPN
dti-1375	622	14	upregulation	upregulation	NOUN
dti-1375	622	15	induces	induce	VERB
dti-1375	622	16	autophagic	autophagic	ADJ
dti-1375	622	17	programmed	program	VERB
dti-1375	622	18	cell	cell	NOUN
dti-1375	622	19	death	death	NOUN
dti-1375	622	20	in	in	ADP
dti-1375	622	21	senescent	senescent	ADJ
dti-1375	622	22	keratinocytes	keratinocyte	NOUN
dti-1375	622	23	.	.	PUNCT
dti-1375	623	1	plos	plos	PROPN
dti-1375	623	2	one	one	NUM
dti-1375	623	3	.	.	PUNCT
dti-1375	624	1	2010;5	2010;5	NUM
dti-1375	624	2	:	:	PUNCT
dti-1375	624	3	e12712	e12712	NOUN
dti-1375	624	4	.	.	PUNCT
dti-1375	625	1	50	50	NUM
dti-1375	625	2	.	.	PUNCT
dti-1375	626	1	marchi	marchi	PROPN
dti-1375	626	2	s	s	PROPN
dti-1375	626	3	,	,	PUNCT
dti-1375	626	4	giorgi	giorgi	PROPN
dti-1375	626	5	c	c	PROPN
dti-1375	626	6	,	,	PUNCT
dti-1375	626	7	suski	suski	PROPN
dti-1375	626	8	jm	jm	PROPN
dti-1375	626	9	,	,	PUNCT
dti-1375	626	10	et	et	PROPN
dti-1375	626	11	al	al	PROPN
dti-1375	626	12	.	.	PROPN
dti-1375	626	13	mitochondria	mitochondria	PROPN
dti-1375	626	14	-	-	PUNCT
dti-1375	626	15	ros	ros	PROPN
dti-1375	626	16	crosstalk	crosstalk	NOUN
dti-1375	626	17	in	in	ADP
dti-1375	626	18	the	the	DET
dti-1375	626	19	control	control	NOUN
dti-1375	626	20	of	of	ADP
dti-1375	626	21	cell	cell	NOUN
dti-1375	626	22	death	death	NOUN
dti-1375	626	23	and	and	CCONJ
dti-1375	626	24	aging	aging	NOUN
dti-1375	626	25	.	.	PUNCT
dti-1375	627	1	j	j	PROPN
dti-1375	627	2	signal	signal	PROPN
dti-1375	627	3	transduct	transduct	NOUN
dti-1375	627	4	.	.	PUNCT
dti-1375	628	1	2012:329635	2012:329635	X
dti-1375	628	2	.	.	PROPN
dti-1375	629	1	51	51	NUM
dti-1375	629	2	.	.	PUNCT
dti-1375	630	1	jahangir	jahangir	PROPN
dti-1375	630	2	a	a	DET
dti-1375	630	3	,	,	PUNCT
dti-1375	630	4	ozcan	ozcan	ADJ
dti-1375	630	5	c	c	X
dti-1375	630	6	,	,	PUNCT
dti-1375	630	7	holmuhamedov	holmuhamedov	PROPN
dti-1375	630	8	el	el	NOUN
dti-1375	630	9	,	,	PUNCT
dti-1375	630	10	terzic	terzic	NOUN
dti-1375	630	11	a.	a.	NOUN
dti-1375	630	12	increased	increase	VERB
dti-1375	630	13	calcium	calcium	NOUN
dti-1375	630	14	vulnerability	vulnerability	NOUN
dti-1375	630	15	of	of	ADP
dti-1375	630	16	senescent	senescent	ADJ
dti-1375	630	17	cardiac	cardiac	ADJ
dti-1375	630	18	mitochondria	mitochondria	NOUN
dti-1375	630	19	:	:	PUNCT
dti-1375	630	20	protective	protective	ADJ
dti-1375	630	21	role	role	NOUN
dti-1375	630	22	for	for	ADP
dti-1375	630	23	a	a	DET
dti-1375	630	24	mitochondrial	mitochondrial	ADJ
dti-1375	630	25	potassium	potassium	NOUN
dti-1375	630	26	channel	channel	NOUN
dti-1375	630	27	opener	opener	NOUN
dti-1375	630	28	.	.	PUNCT
dti-1375	631	1	mech	mech	PROPN
dti-1375	631	2	.	.	PUNCT
dti-1375	632	1	ageing	age	VERB
dti-1375	632	2	dev	dev	PROPN
dti-1375	632	3	.	.	PUNCT
dti-1375	633	1	2001;122	2001;122	NUM
dti-1375	633	2	:	:	PUNCT
dti-1375	634	1	1073–86	1073–86	NUM
dti-1375	634	2	.	.	PUNCT
dti-1375	635	1	52	52	NUM
dti-1375	635	2	.	.	PUNCT
dti-1375	635	3	taiyab	taiyab	NOUN
dti-1375	635	4	a	a	PRON
dti-1375	635	5	,	,	PUNCT
dti-1375	635	6	sreedhar	sreedhar	ADJ
dti-1375	635	7	as	as	ADP
dti-1375	635	8	,	,	PUNCT
dti-1375	635	9	rao	rao	PROPN
dti-1375	635	10	cm	cm	NOUN
dti-1375	635	11	.	.	PUNCT
dti-1375	636	1	hsp90	hsp90	ADJ
dti-1375	636	2	inhibitors	inhibitor	NOUN
dti-1375	636	3	,	,	PUNCT
dti-1375	636	4	ga	ga	PROPN
dti-1375	636	5	and	and	CCONJ
dti-1375	636	6	17aag	17aag	NOUN
dti-1375	636	7	,	,	PUNCT
dti-1375	636	8	lead	lead	VERB
dti-1375	636	9	to	to	ADP
dti-1375	636	10	er	er	INTJ
dti-1375	636	11	stress	stress	NOUN
dti-1375	636	12	-	-	PUNCT
dti-1375	636	13	induced	induce	VERB
dti-1375	636	14	apoptosis	apoptosis	NOUN
dti-1375	636	15	in	in	ADP
dti-1375	636	16	rat	rat	NOUN
dti-1375	636	17	histiocytoma	histiocytoma	NOUN
dti-1375	636	18	.	.	PUNCT
dti-1375	637	1	biochem	biochem	PROPN
dti-1375	637	2	pharmacol	pharmacol	PROPN
dti-1375	637	3	.	.	PUNCT
dti-1375	638	1	2009;78	2009;78	NUM
dti-1375	638	2	:	:	PUNCT
dti-1375	638	3	142–52	142–52	NUM
dti-1375	638	4	.	.	PUNCT
dti-1375	639	1	53	53	NUM
dti-1375	639	2	.	.	PUNCT
dti-1375	639	3	sreedhar	sreedhar	NOUN
dti-1375	639	4	as	as	ADP
dti-1375	639	5	,	,	PUNCT
dti-1375	639	6	pardhasaradhi	pardhasaradhi	PROPN
dti-1375	639	7	bv	bv	PROPN
dti-1375	639	8	,	,	PUNCT
dti-1375	639	9	begum	begum	PROPN
dti-1375	639	10	z	z	PROPN
dti-1375	639	11	,	,	PUNCT
dti-1375	639	12	khar	khar	PROPN
dti-1375	639	13	a	a	PRON
dti-1375	639	14	,	,	PUNCT
dti-1375	639	15	srinivas	srinivas	PROPN
dti-1375	639	16	uk	uk	PROPN
dti-1375	639	17	.	.	PROPN
dti-1375	640	1	lack	lack	NOUN
dti-1375	640	2	of	of	ADP
dti-1375	640	3	heat	heat	NOUN
dti-1375	640	4	shock	shock	NOUN
dti-1375	640	5	response	response	NOUN
dti-1375	640	6	triggers	trigger	NOUN
dti-1375	640	7	programmed	program	VERB
dti-1375	640	8	cell	cell	NOUN
dti-1375	640	9	death	death	NOUN
dti-1375	640	10	in	in	ADP
dti-1375	640	11	a	a	DET
dti-1375	640	12	rat	rat	NOUN
dti-1375	640	13	histiocytic	histiocytic	ADJ
dti-1375	640	14	cell	cell	NOUN
dti-1375	640	15	line	line	NOUN
dti-1375	640	16	.	.	PUNCT
dti-1375	641	1	febs	febs	PROPN
dti-1375	641	2	lett	lett	PROPN
dti-1375	641	3	.	.	PUNCT
dti-1375	642	1	1999;456:339–42	1999;456:339–42	NUM
dti-1375	642	2	.	.	PROPN
dti-1375	643	1	54	54	NUM
dti-1375	643	2	.	.	PUNCT
dti-1375	644	1	afanas’ev	afanas’ev	PROPN
dti-1375	644	2	i.	i.	PROPN
dti-1375	644	3	reactive	reactive	ADJ
dti-1375	644	4	oxygen	oxygen	NOUN
dti-1375	644	5	species	specie	NOUN
dti-1375	644	6	signaling	signal	VERB
dti-1375	644	7	in	in	ADP
dti-1375	644	8	cancer	cancer	NOUN
dti-1375	644	9	:	:	PUNCT
dti-1375	644	10	comparison	comparison	NOUN
dti-1375	644	11	with	with	ADP
dti-1375	644	12	aging	aging	NOUN
dti-1375	644	13	.	.	PUNCT
dti-1375	645	1	aging	age	VERB
dti-1375	645	2	dis	dis	PROPN
dti-1375	645	3	.	.	PUNCT
dti-1375	646	1	2011;2:219–30	2011;2:219–30	NUM
dti-1375	646	2	.	.	PUNCT
dti-1375	647	1	55	55	NUM
dti-1375	647	2	.	.	PUNCT
dti-1375	648	1	demidenko	demidenko	PROPN
dti-1375	648	2	zn	zn	PROPN
dti-1375	648	3	,	,	PUNCT
dti-1375	648	4	zubova	zubova	PROPN
dti-1375	648	5	sg	sg	PROPN
dti-1375	648	6	,	,	PUNCT
dti-1375	648	7	bukreeva	bukreeva	PROPN
dti-1375	648	8	ei	ei	PROPN
dti-1375	648	9	,	,	PUNCT
dti-1375	648	10	pospelov	pospelov	PROPN
dti-1375	648	11	va	va	NOUN
dti-1375	648	12	,	,	PUNCT
dti-1375	648	13	pospelova	pospelova	PROPN
dti-1375	648	14	tv	tv	PROPN
dti-1375	648	15	,	,	PUNCT
dti-1375	648	16	blagosklonny	blagosklonny	VERB
dti-1375	648	17	mv	mv	PROPN
dti-1375	648	18	.	.	PROPN
dti-1375	648	19	rapamycin	rapamycin	PROPN
dti-1375	648	20	decelerates	decelerate	VERB
dti-1375	648	21	cellular	cellular	ADJ
dti-1375	648	22	senescence	senescence	NOUN
dti-1375	648	23	.	.	PUNCT
dti-1375	649	1	cell	cell	NOUN
dti-1375	649	2	cycle	cycle	NOUN
dti-1375	649	3	.	.	PUNCT
dti-1375	650	1	2009;8:1888–95	2009;8:1888–95	X
dti-1375	650	2	.	.	X
dti-1375	650	3	56	56	NUM
dti-1375	650	4	.	.	PUNCT
dti-1375	650	5	park	park	PROPN
dti-1375	650	6	wy	wy	PROPN
dti-1375	650	7	,	,	PUNCT
dti-1375	650	8	cho	cho	PROPN
dti-1375	650	9	ka	ka	PROPN
dti-1375	650	10	,	,	PUNCT
dti-1375	650	11	park	park	PROPN
dti-1375	650	12	js	js	PROPN
dti-1375	650	13	,	,	PUNCT
dti-1375	650	14	kim	kim	PROPN
dti-1375	650	15	di	di	PROPN
dti-1375	650	16	,	,	PUNCT
dti-1375	650	17	park	park	PROPN
dti-1375	650	18	sc	sc	PROPN
dti-1375	650	19	.	.	PROPN
dti-1375	650	20	attenuation	attenuation	NOUN
dti-1375	650	21	of	of	ADP
dti-1375	650	22	egf	egf	PROPN
dti-1375	650	23	signaling	signal	VERB
dti-1375	650	24	in	in	ADP
dti-1375	650	25	senescent	senescent	ADJ
dti-1375	650	26	cells	cell	NOUN
dti-1375	650	27	by	by	ADP
dti-1375	650	28	caveolin	caveolin	PROPN
dti-1375	650	29	.	.	PUNCT
dti-1375	651	1	ann	ann	PROPN
dti-1375	651	2	n	n	PROPN
dti-1375	651	3	y	y	PROPN
dti-1375	651	4	acad	acad	PROPN
dti-1375	651	5	sci	sci	PROPN
dti-1375	651	6	.	.	PUNCT
dti-1375	652	1	2001;928:79–84	2001;928:79–84	NOUN
dti-1375	652	2	.	.	PUNCT
dti-1375	653	1	57	57	NUM
dti-1375	653	2	.	.	X
dti-1375	654	1	ayral	ayral	ADJ
dti-1375	654	2	-	-	PUNCT
dti-1375	654	3	kaloustian	kaloustian	PROPN
dti-1375	654	4	s	s	PROPN
dti-1375	654	5	,	,	PUNCT
dti-1375	654	6	gu	gu	PROPN
dti-1375	654	7	j	j	PROPN
dti-1375	654	8	,	,	PUNCT
dti-1375	654	9	lucas	lucas	PROPN
dti-1375	654	10	j	j	PROPN
dti-1375	654	11	,	,	PUNCT
dti-1375	654	12	et	et	PROPN
dti-1375	654	13	al	al	PROPN
dti-1375	654	14	.	.	PUNCT
dti-1375	654	15	hybrid	hybrid	ADJ
dti-1375	654	16	inhibitors	inhibitor	NOUN
dti-1375	654	17	of	of	ADP
dti-1375	654	18	phosphatidylinositol	phosphatidylinositol	NOUN
dti-1375	654	19	3	3	NUM
dti-1375	654	20	-	-	PUNCT
dti-1375	654	21	kinase	kinase	NOUN
dti-1375	654	22	(	(	PUNCT
dti-1375	654	23	pi3k	pi3k	PROPN
dti-1375	654	24	)	)	PUNCT
dti-1375	654	25	and	and	CCONJ
dti-1375	654	26	the	the	DET
dti-1375	654	27	mammalian	mammalian	ADJ
dti-1375	654	28	target	target	NOUN
dti-1375	654	29	of	of	ADP
dti-1375	654	30	rapamycin	rapamycin	NOUN
dti-1375	654	31	(	(	PUNCT
dti-1375	654	32	mtor	mtor	NOUN
dti-1375	654	33	):	):	PUNCT
dti-1375	654	34	design	design	NOUN
dti-1375	654	35	,	,	PUNCT
dti-1375	654	36	synthesis	synthesis	NOUN
dti-1375	654	37	,	,	PUNCT
dti-1375	654	38	and	and	CCONJ
dti-1375	654	39	superior	superior	ADJ
dti-1375	654	40	antitumor	antitumor	NOUN
dti-1375	654	41	activity	activity	NOUN
dti-1375	654	42	of	of	ADP
dti-1375	654	43	novel	novel	ADJ
dti-1375	654	44	wortmannin	wortmannin	NOUN
dti-1375	654	45	-	-	PUNCT
dti-1375	654	46	rapamycin	rapamycin	NOUN
dti-1375	654	47	conjugates	conjugate	NOUN
dti-1375	654	48	.	.	PUNCT
dti-1375	655	1	j	j	PROPN
dti-1375	655	2	med	med	PROPN
dti-1375	655	3	chem	chem	NOUN
dti-1375	655	4	.	.	PUNCT
dti-1375	656	1	2010;53:452–9	2010;53:452–9	NUM
dti-1375	656	2	.	.	PUNCT
dti-1375	657	1	58	58	NUM
dti-1375	657	2	.	.	PUNCT
dti-1375	658	1	astle	astle	PROPN
dti-1375	658	2	mv	mv	PROPN
dti-1375	658	3	,	,	PUNCT
dti-1375	658	4	hannan	hannan	PROPN
dti-1375	658	5	km	km	PROPN
dti-1375	658	6	,	,	PUNCT
dti-1375	658	7	ng	ng	PROPN
dti-1375	658	8	py	py	PROPN
dti-1375	658	9	,	,	PUNCT
dti-1375	658	10	et	et	PROPN
dti-1375	658	11	al	al	PROPN
dti-1375	658	12	.	.	PUNCT
dti-1375	659	1	akt	akt	PROPN
dti-1375	659	2	induces	induce	VERB
dti-1375	659	3	senescence	senescence	NOUN
dti-1375	659	4	in	in	ADP
dti-1375	659	5	human	human	ADJ
dti-1375	659	6	cells	cell	NOUN
dti-1375	659	7	via	via	ADP
dti-1375	659	8	mtorc1	mtorc1	NOUN
dti-1375	659	9	and	and	CCONJ
dti-1375	659	10	p53	p53	NOUN
dti-1375	659	11	in	in	ADP
dti-1375	659	12	the	the	DET
dti-1375	659	13	absence	absence	NOUN
dti-1375	659	14	of	of	ADP
dti-1375	659	15	dna	dna	PROPN
dti-1375	659	16	damage	damage	NOUN
dti-1375	659	17	:	:	PUNCT
dti-1375	659	18	implications	implication	NOUN
dti-1375	659	19	for	for	ADP
dti-1375	659	20	targeting	target	VERB
dti-1375	659	21	mtor	mtor	NOUN
dti-1375	659	22	during	during	ADP
dti-1375	659	23	malignancy	malignancy	NOUN
dti-1375	659	24	.	.	PUNCT
dti-1375	660	1	oncogene	oncogene	NOUN
dti-1375	660	2	.	.	PUNCT
dti-1375	661	1	2012;31:1949–62	2012;31:1949–62	NUM
dti-1375	661	2	.	.	NOUN
dti-1375	661	3	59	59	NUM
dti-1375	661	4	.	.	PUNCT
dti-1375	661	5	yan	yan	PROPN
dti-1375	662	1	q	q	X
dti-1375	662	2	,	,	PUNCT
dti-1375	662	3	wajapeyee	wajapeyee	X
dti-1375	662	4	n.	n.	NOUN
dti-1375	662	5	exploiting	exploit	VERB
dti-1375	662	6	cellular	cellular	ADJ
dti-1375	662	7	senescence	senescence	NOUN
dti-1375	662	8	to	to	PART
dti-1375	662	9	treat	treat	VERB
dti-1375	662	10	cancer	cancer	NOUN
dti-1375	662	11	and	and	CCONJ
dti-1375	662	12	circumvent	circumvent	VERB
dti-1375	662	13	drug	drug	NOUN
dti-1375	662	14	resistance	resistance	NOUN
dti-1375	662	15	.	.	PUNCT
dti-1375	663	1	cancer	cancer	NOUN
dti-1375	663	2	biol	biol	PROPN
dti-1375	663	3	ther	ther	ADV
dti-1375	663	4	.	.	PUNCT
dti-1375	664	1	2010;9:166–75	2010;9:166–75	X
dti-1375	664	2	.	.	NOUN
dti-1375	664	3	60	60	NUM
dti-1375	664	4	.	.	PUNCT
dti-1375	665	1	shen	shen	PROPN
dti-1375	666	1	f	f	PROPN
dti-1375	666	2	,	,	PUNCT
dti-1375	666	3	chu	chu	PROPN
dti-1375	666	4	s	s	PROPN
dti-1375	666	5	,	,	PUNCT
dti-1375	666	6	bence	bence	NOUN
dti-1375	666	7	ak	ak	PROPN
dti-1375	666	8	,	,	PUNCT
dti-1375	666	9	et	et	PROPN
dti-1375	666	10	al	al	PROPN
dti-1375	666	11	.	.	PUNCT
dti-1375	666	12	quantitation	quantitation	NOUN
dti-1375	666	13	of	of	ADP
dti-1375	666	14	doxorubicin	doxorubicin	PROPN
dti-1375	666	15	uptake	uptake	NOUN
dti-1375	666	16	,	,	PUNCT
dti-1375	666	17	efflux	efflux	VERB
dti-1375	666	18	,	,	PUNCT
dti-1375	666	19	and	and	CCONJ
dti-1375	666	20	modulation	modulation	NOUN
dti-1375	666	21	of	of	ADP
dti-1375	666	22	multidrug	multidrug	NOUN
dti-1375	666	23	resistance	resistance	NOUN
dti-1375	666	24	(	(	PUNCT
dti-1375	666	25	mdr	mdr	PROPN
dti-1375	666	26	)	)	PUNCT
dti-1375	666	27	in	in	ADP
dti-1375	666	28	mdr	mdr	PROPN
dti-1375	666	29	human	human	ADJ
dti-1375	666	30	cancer	cancer	NOUN
dti-1375	666	31	cells	cell	NOUN
dti-1375	666	32	.	.	PUNCT
dti-1375	667	1	j	j	PROPN
dti-1375	667	2	pharmacol	pharmacol	PROPN
dti-1375	667	3	exp	exp	NOUN
dti-1375	667	4	ther	ther	ADV
dti-1375	667	5	.	.	PUNCT
dti-1375	668	1	2008;324:95–102	2008;324:95–102	NUM
dti-1375	668	2	.	.	NOUN
dti-1375	668	3	61	61	NUM
dti-1375	668	4	.	.	PUNCT
dti-1375	669	1	soti	soti	NOUN
dti-1375	669	2	c	c	X
dti-1375	669	3	,	,	PUNCT
dti-1375	669	4	sreedhar	sreedhar	ADJ
dti-1375	669	5	as	as	ADP
dti-1375	669	6	,	,	PUNCT
dti-1375	669	7	csermely	csermely	ADV
dti-1375	669	8	p.	p.	NOUN
dti-1375	669	9	apoptosis	apoptosis	NOUN
dti-1375	669	10	,	,	PUNCT
dti-1375	669	11	necrosis	necrosis	NOUN
dti-1375	669	12	and	and	CCONJ
dti-1375	669	13	cellular	cellular	ADJ
dti-1375	669	14	senescence	senescence	NOUN
dti-1375	669	15	:	:	PUNCT
dti-1375	669	16	chaperone	chaperone	NOUN
dti-1375	669	17	occupancy	occupancy	NOUN
dti-1375	669	18	as	as	ADP
dti-1375	669	19	a	a	DET
dti-1375	669	20	potential	potential	ADJ
dti-1375	669	21	switch	switch	NOUN
dti-1375	669	22	.	.	PUNCT
dti-1375	670	1	aging	age	VERB
dti-1375	670	2	cell	cell	NOUN
dti-1375	670	3	.	.	PUNCT
dti-1375	671	1	2003;2:39–45	2003;2:39–45	NUM
dti-1375	671	2	.	.	X
dti-1375	672	1	62	62	NUM
dti-1375	672	2	.	.	PUNCT
dti-1375	673	1	soti	soti	NOUN
dti-1375	673	2	c	c	X
dti-1375	673	3	,	,	PUNCT
dti-1375	673	4	csermely	csermely	ADV
dti-1375	673	5	p.	p.	ADJ
dti-1375	673	6	molecular	molecular	ADJ
dti-1375	673	7	chaperones	chaperone	NOUN
dti-1375	673	8	and	and	CCONJ
dti-1375	673	9	the	the	DET
dti-1375	673	10	aging	age	VERB
dti-1375	673	11	process	process	NOUN
dti-1375	673	12	.	.	PUNCT
dti-1375	674	1	biogerontology	biogerontology	NOUN
dti-1375	674	2	.	.	PUNCT
dti-1375	675	1	2000;1:225–33	2000;1:225–33	NUM
dti-1375	675	2	.	.	PUNCT
dti-1375	676	1	63	63	NUM
dti-1375	676	2	.	.	PUNCT
dti-1375	677	1	csermely	csermely	ADV
dti-1375	677	2	p.	p.	NOUN
dti-1375	677	3	chaperone	chaperone	NOUN
dti-1375	677	4	overload	overload	NOUN
dti-1375	677	5	is	be	AUX
dti-1375	677	6	a	a	DET
dti-1375	677	7	possible	possible	ADJ
dti-1375	677	8	contributor	contributor	NOUN
dti-1375	677	9	to	to	ADP
dti-1375	677	10	‘	'	PUNCT
dti-1375	677	11	civilization	civilization	NOUN
dti-1375	677	12	diseases	disease	NOUN
dti-1375	677	13	’	'	PUNCT
dti-1375	677	14	.	.	PUNCT
dti-1375	678	1	trends	trend	NOUN
dti-1375	678	2	genet	genet	NOUN
dti-1375	678	3	.	.	PUNCT
dti-1375	679	1	2001;17:701–4	2001;17:701–4	NUM
dti-1375	679	2	.	.	NOUN
dti-1375	680	1	64	64	NUM
dti-1375	680	2	.	.	PUNCT
dti-1375	681	1	campsi	campsi	PROPN
dti-1375	681	2	j.	j.	PROPN
dti-1375	681	3	cancer	cancer	PROPN
dti-1375	681	4	,	,	PUNCT
dti-1375	681	5	aging	aging	NOUN
dti-1375	681	6	and	and	CCONJ
dti-1375	681	7	cellular	cellular	ADJ
dti-1375	681	8	senescence	senescence	NOUN
dti-1375	681	9	.	.	PUNCT
dti-1375	682	1	in	in	ADP
dti-1375	682	2	vivo	vivo	NOUN
dti-1375	682	3	.	.	PUNCT
dti-1375	683	1	2000;14:183–8	2000;14:183–8	NUM
dti-1375	683	2	.	.	PUNCT
dti-1375	684	1	65	65	NUM
dti-1375	684	2	.	.	PUNCT
dti-1375	685	1	krtolica	krtolica	PROPN
dti-1375	685	2	a	a	PROPN
dti-1375	685	3	,	,	PUNCT
dti-1375	685	4	parrienllo	parrienllo	PROPN
dti-1375	685	5	s	s	PROPN
dti-1375	685	6	,	,	PUNCT
dti-1375	685	7	lockett	lockett	PROPN
dti-1375	685	8	s	s	PROPN
dti-1375	685	9	,	,	PUNCT
dti-1375	685	10	desprez	desprez	PROPN
dti-1375	685	11	py	py	PROPN
dti-1375	685	12	,	,	PUNCT
dti-1375	685	13	campisi	campisi	PROPN
dti-1375	685	14	j.	j.	PROPN
dti-1375	685	15	senescent	senescent	PROPN
dti-1375	685	16	fibroblasts	fibroblast	NOUN
dti-1375	685	17	promote	promote	VERB
dti-1375	685	18	epithelial	epithelial	ADJ
dti-1375	685	19	cell	cell	NOUN
dti-1375	685	20	growth	growth	NOUN
dti-1375	685	21	and	and	CCONJ
dti-1375	685	22	tumorigenesis	tumorigenesis	NOUN
dti-1375	685	23	:	:	PUNCT
dti-1375	685	24	a	a	DET
dti-1375	685	25	link	link	NOUN
dti-1375	685	26	between	between	ADP
dti-1375	685	27	cancer	cancer	NOUN
dti-1375	685	28	and	and	CCONJ
dti-1375	685	29	aging	aging	NOUN
dti-1375	685	30	.	.	PUNCT
dti-1375	686	1	proc	proc	NOUN
dti-1375	686	2	nat	nat	PROPN
dti-1375	686	3	acad	acad	PROPN
dti-1375	686	4	sci	sci	PROPN
dti-1375	686	5	u	u	PROPN
dti-1375	686	6	s	s	NOUN
dti-1375	686	7	a.	a.	NOUN
dti-1375	686	8	2001;98:12072–7	2001;98:12072–7	NOUN
dti-1375	686	9	.	.	PUNCT
dti-1375	687	1	66	66	NUM
dti-1375	687	2	.	.	PUNCT
dti-1375	688	1	young	young	PROPN
dti-1375	688	2	ar	ar	PROPN
dti-1375	688	3	,	,	PUNCT
dti-1375	688	4	narita	narita	PROPN
dti-1375	688	5	m.	m.	PROPN
dti-1375	688	6	sasp	sasp	PROPN
dti-1375	688	7	reflects	reflect	VERB
dti-1375	688	8	senescence	senescence	NOUN
dti-1375	688	9	.	.	PUNCT
dti-1375	689	1	embo	embo	PROPN
dti-1375	689	2	rep	rep	PROPN
dti-1375	689	3	.	.	PROPN
dti-1375	689	4	2009;10	2009;10	NUM
dti-1375	689	5	:	:	PUNCT
dti-1375	689	6	228–30	228–30	NUM
dti-1375	689	7	.	.	PROPN
dti-1375	690	1	67	67	NUM
dti-1375	690	2	.	.	PUNCT
dti-1375	691	1	gire	gire	PROPN
dti-1375	691	2	v	v	NOUN
dti-1375	691	3	,	,	PUNCT
dti-1375	691	4	roux	roux	NOUN
dti-1375	691	5	p	p	NOUN
dti-1375	691	6	,	,	PUNCT
dti-1375	692	1	wynford	wynford	PROPN
dti-1375	692	2	-	-	PUNCT
dti-1375	692	3	thomas	thomas	PROPN
dti-1375	692	4	d	d	PROPN
dti-1375	692	5	,	,	PUNCT
dti-1375	692	6	brondello	brondello	PROPN
dti-1375	692	7	jm	jm	PROPN
dti-1375	692	8	,	,	PUNCT
dti-1375	692	9	dulic	dulic	PROPN
dti-1375	692	10	v.	v.	ADP
dti-1375	692	11	dna	dna	PROPN
dti-1375	692	12	damage	damage	NOUN
dti-1375	692	13	checkpoint	checkpoint	NOUN
dti-1375	692	14	kinase	kinase	PROPN
dti-1375	692	15	chk2	chk2	PROPN
dti-1375	692	16	triggers	trigger	VERB
dti-1375	692	17	replicative	replicative	ADJ
dti-1375	692	18	senescence	senescence	NOUN
dti-1375	692	19	.	.	PUNCT
dti-1375	693	1	embo	embo	PROPN
dti-1375	693	2	j.	j.	PROPN
dti-1375	693	3	2004;23:2554–63	2004;23:2554–63	PROPN
dti-1375	693	4	.	.	PROPN
dti-1375	694	1	68	68	NUM
dti-1375	694	2	.	.	PUNCT
dti-1375	694	3	mallette	mallette	PROPN
dti-1375	694	4	fa	fa	PROPN
dti-1375	694	5	,	,	PUNCT
dti-1375	694	6	gaumont	gaumont	PROPN
dti-1375	694	7	-	-	PUNCT
dti-1375	694	8	leclerc	leclerc	PROPN
dti-1375	694	9	mf	mf	PROPN
dti-1375	694	10	,	,	PUNCT
dti-1375	694	11	ferbeyre	ferbeyre	PROPN
dti-1375	694	12	g.	g.	PROPN
dti-1375	694	13	the	the	DET
dti-1375	694	14	dna	dna	PROPN
dti-1375	694	15	damage	damage	NOUN
dti-1375	694	16	signaling	signal	VERB
dti-1375	694	17	pathway	pathway	NOUN
dti-1375	694	18	is	be	AUX
dti-1375	694	19	a	a	DET
dti-1375	694	20	critical	critical	ADJ
dti-1375	694	21	mediator	mediator	NOUN
dti-1375	694	22	of	of	ADP
dti-1375	694	23	oncogene	oncogene	NOUN
dti-1375	694	24	-	-	PUNCT
dti-1375	694	25	induced	induce	VERB
dti-1375	694	26	senescence	senescence	NOUN
dti-1375	694	27	.	.	PUNCT
dti-1375	695	1	genes	gene	NOUN
dti-1375	695	2	dev	dev	PROPN
dti-1375	695	3	.	.	PUNCT
dti-1375	696	1	2007;21:43–8	2007;21:43–8	PROPN
dti-1375	696	2	.	.	PUNCT
dti-1375	696	3	http://www.la-press.com	http://www.la-press.com	X
dti-1375	697	1	hsp90	hsp90	ADJ
dti-1375	697	2	inhibition	inhibition	NOUN
dti-1375	697	3	accelerates	accelerate	VERB
dti-1375	697	4	senescence	senescence	NOUN
dti-1375	697	5	drug	drug	NOUN
dti-1375	697	6	target	target	NOUN
dti-1375	697	7	insights	insight	NOUN
dti-1375	697	8	2012:6	2012:6	NUM
dti-1375	697	9	37	37	NUM
dti-1375	697	10	supplementary	supplementary	ADJ
dti-1375	697	11	figures	figure	NOUN
dti-1375	697	12	figure	figure	VERB
dti-1375	697	13	s1	s1	PROPN
dti-1375	697	14	.	.	PUNCT
dti-1375	698	1	effect	effect	NOUN
dti-1375	698	2	of	of	ADP
dti-1375	698	3	17aag	17aag	NOUN
dti-1375	698	4	,	,	PUNCT
dti-1375	698	5	doxorubicin	doxorubicin	PROPN
dti-1375	698	6	and	and	CCONJ
dti-1375	698	7	their	their	PRON
dti-1375	698	8	combination	combination	NOUN
dti-1375	698	9	on	on	ADP
dti-1375	698	10	cell	cell	NOUN
dti-1375	698	11	morphology	morphology	NOUN
dti-1375	698	12	and	and	CCONJ
dti-1375	698	13	cytotoxicity	cytotoxicity	NOUN
dti-1375	698	14	.	.	PUNCT
dti-1375	699	1	(	(	PUNCT
dti-1375	699	2	a	a	X
dti-1375	699	3	)	)	PUNCT
dti-1375	699	4	cells	cell	NOUN
dti-1375	699	5	after	after	SCONJ
dti-1375	699	6	respective	respective	ADJ
dti-1375	699	7	treatments	treatment	NOUN
dti-1375	699	8	were	be	AUX
dti-1375	699	9	observed	observe	VERB
dti-1375	699	10	under	under	ADP
dti-1375	699	11	microscope	microscope	NOUN
dti-1375	699	12	and	and	CCONJ
dti-1375	699	13	phase	phase	NOUN
dti-1375	699	14	contrast	contrast	NOUN
dti-1375	699	15	images	image	NOUN
dti-1375	699	16	in	in	ADP
dti-1375	699	17	10x	10x	NOUN
dti-1375	699	18	magnification	magnification	NOUN
dti-1375	699	19	were	be	AUX
dti-1375	699	20	represented	represent	VERB
dti-1375	699	21	.	.	PUNCT
dti-1375	700	1	(	(	PUNCT
dti-1375	700	2	b	b	X
dti-1375	700	3	)	)	PUNCT
dti-1375	700	4	cells	cell	NOUN
dti-1375	700	5	were	be	AUX
dti-1375	700	6	stained	stain	VERB
dti-1375	700	7	with	with	ADP
dti-1375	700	8	propidium	propidium	NOUN
dti-1375	700	9	iodide	iodide	NOUN
dti-1375	700	10	and	and	CCONJ
dti-1375	700	11	the	the	DET
dti-1375	700	12	dna	dna	PROPN
dti-1375	700	13	content	content	NOUN
dti-1375	700	14	was	be	AUX
dti-1375	700	15	analyzed	analyze	VERB
dti-1375	700	16	by	by	ADP
dti-1375	700	17	facs	fac	NOUN
dti-1375	700	18	.	.	PUNCT
dti-1375	701	1	control	control	NOUN
dti-1375	701	2	1	1	NUM
dti-1375	701	3	d	d	NOUN
dti-1375	701	4	doxorubicin	doxorubicin	PROPN
dti-1375	701	5	17aag	17aag	PROPN
dti-1375	701	6	dox	dox	PROPN
dti-1375	701	7	+	+	CCONJ
dti-1375	701	8	17aag	17aag	NOUN
dti-1375	701	9	2	2	NUM
dti-1375	701	10	d	d	SYM
dti-1375	701	11	3	3	NUM
dti-1375	701	12	d	d	SYM
dti-1375	701	13	4	4	NUM
dti-1375	701	14	d	d	SYM
dti-1375	701	15	5	5	NUM
dti-1375	701	16	d	d	SYM
dti-1375	701	17	6	6	NUM
dti-1375	701	18	d	d	NOUN
dti-1375	701	19	0	0	NUM
dti-1375	701	20	con	con	X
dti-1375	701	21	tro	tro	X
dti-1375	701	22	l	l	NOUN
dti-1375	701	23	1	1	NUM
dti-1375	701	24	2	2	NUM
dti-1375	701	25	3	3	NUM
dti-1375	701	26	4	4	NUM
dti-1375	701	27	5	5	NUM
dti-1375	701	28	6	6	NUM
dti-1375	701	29	20	20	NUM
dti-1375	701	30	40	40	NUM
dti-1375	701	31	60	60	NUM
dti-1375	701	32	80	80	NUM
dti-1375	701	33	100	100	NUM
dti-1375	701	34	p	p	NOUN
dti-1375	701	35	er	er	INTJ
dti-1375	701	36	ce	ce	PROPN
dti-1375	701	37	n	n	PROPN
dti-1375	701	38	t	t	PROPN
dti-1375	701	39	ce	ce	PROPN
dti-1375	701	40	ll	ll	PROPN
dti-1375	701	41	d	d	PROPN
dti-1375	701	42	ea	ea	X
dti-1375	701	43	th	th	X
dti-1375	701	44	doxorubicin	doxorubicin	PROPN
dti-1375	701	45	0	0	NUM
dti-1375	701	46	con	con	PROPN
dti-1375	701	47	tro	tro	X
dti-1375	701	48	l	l	NOUN
dti-1375	701	49	1	1	NUM
dti-1375	701	50	2	2	NUM
dti-1375	701	51	3	3	NUM
dti-1375	701	52	4	4	NUM
dti-1375	701	53	5	5	NUM
dti-1375	701	54	6	6	NUM
dti-1375	701	55	20	20	NUM
dti-1375	701	56	40	40	NUM
dti-1375	701	57	60	60	NUM
dti-1375	701	58	80	80	NUM
dti-1375	701	59	100	100	NUM
dti-1375	701	60	p	p	NOUN
dti-1375	701	61	er	er	INTJ
dti-1375	701	62	ce	ce	PROPN
dti-1375	701	63	n	n	PROPN
dti-1375	701	64	t	t	PROPN
dti-1375	701	65	ce	ce	PROPN
dti-1375	701	66	ll	ll	PROPN
dti-1375	701	67	d	d	PROPN
dti-1375	701	68	ea	ea	X
dti-1375	701	69	th	th	X
dti-1375	701	70	17aag	17aag	NOUN
dti-1375	701	71	0	0	NUM
dti-1375	701	72	con	con	X
dti-1375	701	73	tro	tro	X
dti-1375	701	74	l	l	NOUN
dti-1375	701	75	1	1	NUM
dti-1375	701	76	2	2	NUM
dti-1375	701	77	3	3	NUM
dti-1375	701	78	4	4	NUM
dti-1375	701	79	5	5	NUM
dti-1375	701	80	6	6	NUM
dti-1375	701	81	20	20	NUM
dti-1375	701	82	40	40	NUM
dti-1375	701	83	60	60	NUM
dti-1375	701	84	80	80	NUM
dti-1375	701	85	100	100	NUM
dti-1375	701	86	p	p	NOUN
dti-1375	701	87	er	er	INTJ
dti-1375	701	88	ce	ce	PROPN
dti-1375	701	89	n	n	PROPN
dti-1375	701	90	t	t	PROPN
dti-1375	701	91	ce	ce	PROPN
dti-1375	701	92	ll	ll	PROPN
dti-1375	701	93	d	d	PROPN
dti-1375	701	94	ea	ea	X
dti-1375	701	95	th	th	X
dti-1375	701	96	doxo	doxo	PROPN
dti-1375	701	97	+	+	CCONJ
dti-1375	701	98	17aag	17aag	NOUN
dti-1375	701	99	a	a	DET
dti-1375	701	100	b	b	NOUN
dti-1375	701	101	http://www.la-press.com	http://www.la-press.com	X
dti-1375	701	102	sarangi	sarangi	PROPN
dti-1375	701	103	et	et	PROPN
dti-1375	701	104	al	al	PROPN
dti-1375	701	105	38	38	NUM
dti-1375	701	106	drug	drug	NOUN
dti-1375	701	107	target	target	NOUN
dti-1375	701	108	insights	insight	NOUN
dti-1375	701	109	2012:6	2012:6	NUM
dti-1375	701	110	figure	figure	NOUN
dti-1375	701	111	s2	s2	PROPN
dti-1375	701	112	.	.	PUNCT
dti-1375	702	1	effect	effect	NOUN
dti-1375	702	2	of	of	ADP
dti-1375	702	3	drugs	drug	NOUN
dti-1375	702	4	pre	pre	NOUN
dti-1375	702	5	-	-	NOUN
dti-1375	702	6	treatments	treatment	NOUN
dti-1375	702	7	on	on	ADP
dti-1375	702	8	cell	cell	NOUN
dti-1375	702	9	morphology	morphology	NOUN
dti-1375	702	10	and	and	CCONJ
dti-1375	702	11	cytotoxicity	cytotoxicity	NOUN
dti-1375	702	12	.	.	PUNCT
dti-1375	703	1	(	(	PUNCT
dti-1375	703	2	a	a	X
dti-1375	703	3	)	)	PUNCT
dti-1375	703	4	cells	cell	NOUN
dti-1375	703	5	either	either	CCONJ
dti-1375	703	6	treated	treat	VERB
dti-1375	703	7	with	with	ADP
dti-1375	703	8	doxorubicin	doxorubicin	PROPN
dti-1375	703	9	or	or	CCONJ
dti-1375	703	10	17aag	17aag	NOUN
dti-1375	703	11	for	for	ADP
dti-1375	703	12	24	24	NUM
dti-1375	703	13	h	h	NOUN
dti-1375	703	14	followed	follow	VERB
dti-1375	703	15	by	by	ADP
dti-1375	703	16	second	second	ADJ
dti-1375	703	17	drug	drug	NOUN
dti-1375	703	18	treatment	treatment	NOUN
dti-1375	703	19	for	for	ADP
dti-1375	703	20	5	5	NUM
dti-1375	703	21	-	-	PUNCT
dti-1375	703	22	days	day	NOUN
dti-1375	703	23	were	be	AUX
dti-1375	703	24	observed	observe	VERB
dti-1375	703	25	under	under	ADP
dti-1375	703	26	microscope	microscope	NOUN
dti-1375	703	27	and	and	CCONJ
dti-1375	703	28	the	the	DET
dti-1375	703	29	phase	phase	NOUN
dti-1375	703	30	contrast	contrast	NOUN
dti-1375	703	31	images	image	NOUN
dti-1375	703	32	were	be	AUX
dti-1375	703	33	represented	represent	VERB
dti-1375	703	34	.	.	PUNCT
dti-1375	704	1	(	(	PUNCT
dti-1375	704	2	b	b	X
dti-1375	704	3	)	)	PUNCT
dti-1375	704	4	cells	cell	NOUN
dti-1375	704	5	stained	stain	VERB
dti-1375	704	6	with	with	ADP
dti-1375	704	7	propidium	propidium	NOUN
dti-1375	704	8	iodide	iodide	NOUN
dti-1375	704	9	and	and	CCONJ
dti-1375	704	10	the	the	DET
dti-1375	704	11	dna	dna	PROPN
dti-1375	704	12	content	content	NOUN
dti-1375	704	13	was	be	AUX
dti-1375	704	14	analyzed	analyze	VERB
dti-1375	704	15	by	by	ADP
dti-1375	704	16	facs	fac	NOUN
dti-1375	704	17	.	.	PUNCT
dti-1375	705	1	control	control	VERB
dti-1375	705	2	dox--17aag	dox--17aag	DET
dti-1375	705	3	17aag	17aag	NOUN
dti-1375	705	4	--	--	PUNCT
dti-1375	705	5	dox	dox	NOUN
dti-1375	705	6	2	2	NUM
dti-1375	705	7	d	d	SYM
dti-1375	705	8	3	3	NUM
dti-1375	705	9	d	d	SYM
dti-1375	705	10	4	4	NUM
dti-1375	705	11	d	d	SYM
dti-1375	705	12	5	5	NUM
dti-1375	705	13	d	d	SYM
dti-1375	705	14	6	6	NUM
dti-1375	705	15	d	d	NOUN
dti-1375	705	16	0	0	NUM
dti-1375	705	17	con	con	X
dti-1375	705	18	tro	tro	X
dti-1375	705	19	l	l	NOUN
dti-1375	705	20	1	1	NUM
dti-1375	705	21	2	2	NUM
dti-1375	705	22	3	3	NUM
dti-1375	705	23	4	4	NUM
dti-1375	705	24	5	5	NUM
dti-1375	705	25	6	6	NUM
dti-1375	705	26	20	20	NUM
dti-1375	705	27	40	40	NUM
dti-1375	705	28	60	60	NUM
dti-1375	705	29	80	80	NUM
dti-1375	705	30	100	100	NUM
dti-1375	705	31	p	p	NOUN
dti-1375	705	32	er	er	INTJ
dti-1375	705	33	ce	ce	PROPN
dti-1375	705	34	n	n	PROPN
dti-1375	705	35	t	t	PROPN
dti-1375	705	36	ce	ce	PROPN
dti-1375	705	37	ll	ll	PROPN
dti-1375	705	38	d	d	PROPN
dti-1375	705	39	ea	ea	X
dti-1375	705	40	th	th	X
dti-1375	705	41	doxorubicin--17aag	doxorubicin--17aag	VERB
dti-1375	705	42	0	0	NUM
dti-1375	705	43	con	con	NOUN
dti-1375	705	44	tro	tro	X
dti-1375	705	45	l	l	NOUN
dti-1375	705	46	1	1	NUM
dti-1375	705	47	2	2	NUM
dti-1375	705	48	3	3	NUM
dti-1375	705	49	4	4	NUM
dti-1375	705	50	5	5	NUM
dti-1375	705	51	6	6	NUM
dti-1375	705	52	20	20	NUM
dti-1375	705	53	40	40	NUM
dti-1375	705	54	60	60	NUM
dti-1375	705	55	80	80	NUM
dti-1375	705	56	100	100	NUM
dti-1375	705	57	p	p	NOUN
dti-1375	705	58	er	er	INTJ
dti-1375	705	59	ce	ce	PROPN
dti-1375	705	60	n	n	PROPN
dti-1375	705	61	t	t	PROPN
dti-1375	705	62	ce	ce	PROPN
dti-1375	705	63	ll	ll	PROPN
dti-1375	705	64	d	d	PROPN
dti-1375	705	65	ea	ea	X
dti-1375	705	66	th	th	X
dti-1375	705	67	17aag	17aag	NOUN
dti-1375	705	68	-	-	PUNCT
dti-1375	705	69	doxorubicin	doxorubicin	ADJ
dti-1375	705	70	days	day	NOUN
dti-1375	705	71	after	after	ADP
dti-1375	705	72	treatment	treatment	NOUN
dti-1375	705	73	days	day	NOUN
dti-1375	705	74	after	after	ADP
dti-1375	705	75	treatment	treatment	NOUN
dti-1375	705	76	a	a	DET
dti-1375	705	77	b	b	NOUN
dti-1375	705	78	http://www.la-press.com	http://www.la-press.com	X
dti-1375	706	1	hsp90	hsp90	ADJ
dti-1375	706	2	inhibition	inhibition	NOUN
dti-1375	706	3	accelerates	accelerate	VERB
dti-1375	706	4	senescence	senescence	NOUN
dti-1375	706	5	drug	drug	NOUN
dti-1375	706	6	target	target	NOUN
dti-1375	706	7	insights	insight	NOUN
dti-1375	706	8	2012:6	2012:6	NUM
dti-1375	706	9	39	39	NUM
dti-1375	706	10	figure	figure	NOUN
dti-1375	706	11	s3	s3	PROPN
dti-1375	706	12	.	.	PUNCT
dti-1375	707	1	the	the	DET
dti-1375	707	2	rt	rt	ADJ
dti-1375	707	3	-	-	PUNCT
dti-1375	707	4	pcr	pcr	NOUN
dti-1375	707	5	analysis	analysis	NOUN
dti-1375	707	6	of	of	ADP
dti-1375	707	7	sirna	sirna	PROPN
dti-1375	707	8	to	to	ADP
dti-1375	707	9	hsp90	hsp90	ADJ
dti-1375	707	10	transfected	transfecte	VERB
dti-1375	707	11	cells	cell	NOUN
dti-1375	707	12	.	.	PUNCT
dti-1375	708	1	sirnacontrol	sirnacontrol	NOUN
dti-1375	708	2	0	0	NUM
dti-1375	708	3	25	25	NUM
dti-1375	708	4	50	50	NUM
dti-1375	708	5	g	g	ADP
dti-1375	708	6	a	a	DET
dti-1375	708	7	p	p	X
dti-1375	708	8	d	d	X
dti-1375	708	9	h	h	NOUN
dti-1375	708	10	/h	/h	NOUN
dti-1375	708	11	sp	sp	ADP
dti-1375	708	12	90	90	NUM
dti-1375	708	13	m	m	NOUN
dti-1375	708	14	r	r	NOUN
dti-1375	708	15	n	n	ADV
dti-1375	708	16	a	a	PRON
dti-1375	708	17	(	(	PUNCT
dti-1375	708	18	o	o	NOUN
dti-1375	708	19	rb	rb	NOUN
dti-1375	708	20	it	it	PRON
dti-1375	708	21	ra	ra	INTJ
dti-1375	709	1	ry	ry	INTJ
dti-1375	709	2	u	u	PROPN
dti-1375	709	3	n	n	PROPN
dti-1375	709	4	it	it	PRON
dti-1375	709	5	s	s	VERB
dti-1375	709	6	)	)	PUNCT
dti-1375	709	7	http://www.la-press.com	http://www.la-press.com	X