id	sid	tid	token	lemma	pos
dti-1378	1	1	drug	drug	NOUN
dti-1378	1	2	target	target	NOUN
dti-1378	1	3	insights	insight	NOUN
dti-1378	1	4	2012:6	2012:6	NUM
dti-1378	1	5	41–58	41–58	NUM
dti-1378	1	6	doi	doi	NOUN
dti-1378	1	7	:	:	PUNCT
dti-1378	1	8	10.4137	10.4137	NUM
dti-1378	1	9	/	/	SYM
dti-1378	1	10	dti.s10219	dti.s10219	NOUN
dti-1378	1	11	this	this	DET
dti-1378	1	12	article	article	NOUN
dti-1378	1	13	is	be	AUX
dti-1378	1	14	available	available	ADJ
dti-1378	1	15	from	from	ADP
dti-1378	1	16	http://www.la-press.com	http://www.la-press.com	X
dti-1378	1	17	.	.	PUNCT
dti-1378	2	1	©	©	ADP
dti-1378	2	2	the	the	DET
dti-1378	2	3	author(s	author(s	PROPN
dti-1378	2	4	)	)	PUNCT
dti-1378	2	5	,	,	PUNCT
dti-1378	2	6	publisher	publisher	NOUN
dti-1378	2	7	and	and	CCONJ
dti-1378	2	8	licensee	licensee	PROPN
dti-1378	2	9	libertas	libertas	PROPN
dti-1378	2	10	academica	academica	PROPN
dti-1378	2	11	ltd	ltd	PROPN
dti-1378	2	12	.	.	PUNCT
dti-1378	3	1	this	this	PRON
dti-1378	3	2	is	be	AUX
dti-1378	3	3	an	an	DET
dti-1378	3	4	open	open	ADJ
dti-1378	3	5	access	access	NOUN
dti-1378	3	6	article	article	NOUN
dti-1378	3	7	.	.	PUNCT
dti-1378	4	1	unrestricted	unrestricted	ADJ
dti-1378	4	2	non	non	ADJ
dti-1378	4	3	-	-	ADJ
dti-1378	4	4	commercial	commercial	ADJ
dti-1378	4	5	use	use	NOUN
dti-1378	4	6	is	be	AUX
dti-1378	4	7	permitted	permit	VERB
dti-1378	4	8	provided	provide	VERB
dti-1378	4	9	the	the	DET
dti-1378	4	10	original	original	ADJ
dti-1378	4	11	work	work	NOUN
dti-1378	4	12	is	be	AUX
dti-1378	4	13	properly	properly	ADV
dti-1378	4	14	cited	cite	VERB
dti-1378	4	15	.	.	PUNCT
dti-1378	5	1	open	open	ADJ
dti-1378	5	2	access	access	NOUN
dti-1378	5	3	full	full	ADJ
dti-1378	5	4	open	open	ADJ
dti-1378	5	5	access	access	NOUN
dti-1378	5	6	to	to	ADP
dti-1378	5	7	this	this	PRON
dti-1378	5	8	and	and	CCONJ
dti-1378	5	9	thousands	thousand	NOUN
dti-1378	5	10	of	of	ADP
dti-1378	5	11	other	other	ADJ
dti-1378	5	12	papers	paper	NOUN
dti-1378	5	13	at	at	ADP
dti-1378	5	14	http://www.la-press.com	http://www.la-press.com	X
dti-1378	5	15	.	.	PUNCT
dti-1378	6	1	drug	drug	NOUN
dti-1378	6	2	target	target	NOUN
dti-1378	6	3	insights	insight	NOUN
dti-1378	6	4	o	o	NOUN
dti-1378	6	5	r	r	NOUN
dti-1378	7	1	i	i	PRON
dti-1378	7	2	g	g	VERB
dti-1378	8	1	i	i	PRON
dti-1378	8	2	n	n	CCONJ
dti-1378	8	3	a	a	DET
dti-1378	8	4	l	l	NOUN
dti-1378	8	5	r	r	NOUN
dti-1378	8	6	e	e	NOUN
dti-1378	8	7	s	s	X
dti-1378	8	8	e	e	X
dti-1378	8	9	a	a	DET
dti-1378	8	10	r	r	NOUN
dti-1378	8	11	c	c	NOUN
dti-1378	8	12	h	h	NOUN
dti-1378	8	13	drug	drug	NOUN
dti-1378	8	14	target	target	NOUN
dti-1378	8	15	insights	insight	NOUN
dti-1378	8	16	2012:6	2012:6	NUM
dti-1378	8	17	41	41	NUM
dti-1378	8	18	drug	drug	NOUN
dti-1378	8	19	target	target	NOUN
dti-1378	8	20	exploitable	exploitable	VERB
dti-1378	8	21	structural	structural	ADJ
dti-1378	8	22	features	feature	NOUN
dti-1378	8	23	of	of	ADP
dti-1378	8	24	adenylyl	adenylyl	ADJ
dti-1378	8	25	cyclase	cyclase	NOUN
dti-1378	8	26	activity	activity	NOUN
dti-1378	8	27	in	in	ADP
dti-1378	8	28	schistosoma	schistosoma	ADJ
dti-1378	8	29	mansoni	mansoni	ADJ
dti-1378	8	30	andreas	andreas	PROPN
dti-1378	8	31	n.	n.	PROPN
dti-1378	8	32	mbah1,2	mbah1,2	PROPN
dti-1378	8	33	,	,	PUNCT
dti-1378	8	34	henri	henri	PROPN
dti-1378	8	35	l.	l.	PROPN
dti-1378	8	36	kamga3	kamga3	PROPN
dti-1378	8	37	,	,	PUNCT
dti-1378	8	38	omotayo	omotayo	VERB
dti-1378	8	39	r.	r.	PROPN
dti-1378	8	40	awofolu2	awofolu2	PROPN
dti-1378	8	41	and	and	CCONJ
dti-1378	8	42	raphael	raphael	PROPN
dti-1378	8	43	d.	d.	PROPN
dti-1378	8	44	isokpehi1	isokpehi1	PROPN
dti-1378	8	45	1center	1center	NUM
dti-1378	8	46	for	for	ADP
dti-1378	8	47	bioinformatics	bioinformatics	NOUN
dti-1378	8	48	&	&	CCONJ
dti-1378	8	49	computational	computational	ADJ
dti-1378	8	50	biology	biology	NOUN
dti-1378	8	51	,	,	PUNCT
dti-1378	8	52	department	department	NOUN
dti-1378	8	53	of	of	ADP
dti-1378	8	54	biology	biology	NOUN
dti-1378	8	55	,	,	PUNCT
dti-1378	8	56	jackson	jackson	PROPN
dti-1378	8	57	state	state	PROPN
dti-1378	8	58	university	university	PROPN
dti-1378	8	59	,	,	PUNCT
dti-1378	8	60	jackson	jackson	PROPN
dti-1378	8	61	,	,	PUNCT
dti-1378	8	62	ms	ms	PROPN
dti-1378	8	63	,	,	PUNCT
dti-1378	8	64	usa	usa	PROPN
dti-1378	8	65	.	.	PROPN
dti-1378	9	1	2department	2department	NUM
dti-1378	9	2	of	of	ADP
dti-1378	9	3	environmental	environmental	ADJ
dti-1378	9	4	sciences	sciences	PROPN
dti-1378	9	5	,	,	PUNCT
dti-1378	9	6	college	college	NOUN
dti-1378	9	7	of	of	ADP
dti-1378	9	8	agriculture	agriculture	PROPN
dti-1378	9	9	and	and	CCONJ
dti-1378	9	10	environmental	environmental	ADJ
dti-1378	9	11	sciences	science	NOUN
dti-1378	9	12	,	,	PUNCT
dti-1378	9	13	university	university	NOUN
dti-1378	9	14	of	of	ADP
dti-1378	9	15	south	south	PROPN
dti-1378	9	16	africa	africa	PROPN
dti-1378	9	17	,	,	PUNCT
dti-1378	9	18	south	south	PROPN
dti-1378	9	19	africa	africa	PROPN
dti-1378	9	20	.	.	PUNCT
dti-1378	10	1	3faculty	3faculty	NUM
dti-1378	10	2	of	of	ADP
dti-1378	10	3	health	health	NOUN
dti-1378	10	4	sciences	sciences	PROPN
dti-1378	10	5	,	,	PUNCT
dti-1378	10	6	university	university	NOUN
dti-1378	10	7	of	of	ADP
dti-1378	10	8	buea	buea	NOUN
dti-1378	10	9	,	,	PUNCT
dti-1378	10	10	buea	buea	NOUN
dti-1378	10	11	,	,	PUNCT
dti-1378	10	12	south	south	ADJ
dti-1378	10	13	west	west	PROPN
dti-1378	10	14	region	region	PROPN
dti-1378	10	15	,	,	PUNCT
dti-1378	10	16	cameroon	cameroon	NOUN
dti-1378	10	17	.	.	PUNCT
dti-1378	11	1	corresponding	correspond	VERB
dti-1378	11	2	author	author	NOUN
dti-1378	11	3	email	email	NOUN
dti-1378	11	4	:	:	PUNCT
dti-1378	11	5	raphael.isokpehi@jsums.edu	raphael.isokpehi@jsums.edu	NOUN
dti-1378	11	6	abstract	abstract	ADJ
dti-1378	11	7	:	:	PUNCT
dti-1378	11	8	the	the	DET
dti-1378	11	9	draft	draft	NOUN
dti-1378	11	10	genome	genome	NOUN
dti-1378	11	11	sequence	sequence	NOUN
dti-1378	11	12	of	of	ADP
dti-1378	11	13	the	the	DET
dti-1378	11	14	parasitic	parasitic	ADJ
dti-1378	11	15	flatworm	flatworm	NOUN
dti-1378	11	16	schistosoma	schistosoma	ADJ
dti-1378	11	17	mansoni	mansoni	NOUN
dti-1378	11	18	(	(	PUNCT
dti-1378	11	19	s.	s.	PROPN
dti-1378	11	20	mansoni	mansoni	PROPN
dti-1378	11	21	)	)	PUNCT
dti-1378	11	22	,	,	PUNCT
dti-1378	11	23	a	a	DET
dti-1378	11	24	cause	cause	NOUN
dti-1378	11	25	of	of	ADP
dti-1378	11	26	schistosomiasis	schistosomiasis	NOUN
dti-1378	11	27	,	,	PUNCT
dti-1378	11	28	encodes	encode	VERB
dti-1378	11	29	a	a	DET
dti-1378	11	30	predicted	predict	VERB
dti-1378	11	31	guanosine	guanosine	NOUN
dti-1378	11	32	triphosphate	triphosphate	NOUN
dti-1378	11	33	(	(	PUNCT
dti-1378	11	34	gtp	gtp	NOUN
dti-1378	11	35	)	)	PUNCT
dti-1378	11	36	binding	bind	VERB
dti-1378	11	37	protein	protein	NOUN
dti-1378	11	38	tagged	tag	VERB
dti-1378	11	39	smp_059340.1	smp_059340.1	PROPN
dti-1378	11	40	.	.	PUNCT
dti-1378	12	1	smp_059340.1	smp_059340.1	PROPN
dti-1378	12	2	is	be	AUX
dti-1378	12	3	predicted	predict	VERB
dti-1378	12	4	to	to	PART
dti-1378	12	5	be	be	AUX
dti-1378	12	6	a	a	DET
dti-1378	12	7	member	member	NOUN
dti-1378	12	8	of	of	ADP
dti-1378	12	9	the	the	DET
dti-1378	12	10	g	g	PROPN
dti-1378	12	11	protein	protein	NOUN
dti-1378	12	12	alpha	alpha	NOUN
dti-1378	12	13	-	-	PUNCT
dti-1378	12	14	s	s	PART
dti-1378	12	15	subunit	subunit	NOUN
dti-1378	12	16	responsible	responsible	ADJ
dti-1378	12	17	for	for	ADP
dti-1378	12	18	regulating	regulate	VERB
dti-1378	12	19	adenylyl	adenylyl	NOUN
dti-1378	12	20	cyclase	cyclase	NOUN
dti-1378	12	21	activity	activity	NOUN
dti-1378	12	22	in	in	ADP
dti-1378	12	23	s.	s.	PROPN
dti-1378	12	24	mansoni	mansoni	PROPN
dti-1378	12	25	and	and	CCONJ
dti-1378	12	26	a	a	DET
dti-1378	12	27	possible	possible	ADJ
dti-1378	12	28	drug	drug	NOUN
dti-1378	12	29	target	target	NOUN
dti-1378	12	30	against	against	ADP
dti-1378	12	31	the	the	DET
dti-1378	12	32	parasite	parasite	NOUN
dti-1378	12	33	.	.	PUNCT
dti-1378	13	1	our	our	PRON
dti-1378	13	2	structural	structural	ADJ
dti-1378	13	3	bioinformatics	bioinformatics	NOUN
dti-1378	13	4	analyses	analysis	NOUN
dti-1378	13	5	identified	identify	VERB
dti-1378	13	6	key	key	ADJ
dti-1378	13	7	amino	amino	NOUN
dti-1378	13	8	acid	acid	NOUN
dti-1378	13	9	residues	residue	NOUN
dti-1378	13	10	(	(	PUNCT
dti-1378	13	11	ser53	ser53	NOUN
dti-1378	13	12	,	,	PUNCT
dti-1378	13	13	thr188	thr188	PROPN
dti-1378	13	14	,	,	PUNCT
dti-1378	13	15	asp207	asp207	NOUN
dti-1378	13	16	and	and	CCONJ
dti-1378	13	17	gly210	gly210	PROPN
dti-1378	13	18	)	)	PUNCT
dti-1378	13	19	in	in	ADP
dti-1378	13	20	the	the	DET
dti-1378	13	21	two	two	NUM
dti-1378	13	22	molecular	molecular	ADJ
dti-1378	13	23	switches	switch	NOUN
dti-1378	13	24	responsible	responsible	ADJ
dti-1378	13	25	for	for	ADP
dti-1378	13	26	cycling	cycle	VERB
dti-1378	13	27	the	the	DET
dti-1378	13	28	protein	protein	NOUN
dti-1378	13	29	between	between	ADP
dti-1378	13	30	active	active	ADJ
dti-1378	13	31	(	(	PUNCT
dti-1378	13	32	gtp	gtp	NOUN
dti-1378	13	33	bound	bind	VERB
dti-1378	13	34	)	)	PUNCT
dti-1378	13	35	and	and	CCONJ
dti-1378	13	36	inactive	inactive	ADJ
dti-1378	13	37	(	(	PUNCT
dti-1378	13	38	gdp	gdp	NOUN
dti-1378	13	39	bound	bind	VERB
dti-1378	13	40	)	)	PUNCT
dti-1378	13	41	states	state	NOUN
dti-1378	13	42	.	.	PUNCT
dti-1378	14	1	residue	residue	NOUN
dti-1378	14	2	thr188	thr188	NOUN
dti-1378	14	3	is	be	AUX
dti-1378	14	4	located	locate	VERB
dti-1378	14	5	on	on	ADP
dti-1378	14	6	switch	switch	NOUN
dti-1378	14	7	i	i	PRON
dti-1378	14	8	region	region	NOUN
dti-1378	14	9	while	while	SCONJ
dti-1378	14	10	gly210	gly210	NOUN
dti-1378	14	11	is	be	AUX
dti-1378	14	12	located	locate	VERB
dti-1378	14	13	on	on	ADP
dti-1378	14	14	switch	switch	NOUN
dti-1378	14	15	ii	ii	PROPN
dti-1378	14	16	region	region	NOUN
dti-1378	14	17	with	with	ADP
dti-1378	14	18	switch	switch	NOUN
dti-1378	14	19	ii	ii	PROPN
dti-1378	14	20	longer	long	ADV
dti-1378	14	21	than	than	SCONJ
dti-1378	14	22	switch	switch	VERB
dti-1378	14	23	i.	i.	PROPN
dti-1378	14	24	the	the	DET
dti-1378	14	25	asp207	asp207	PROPN
dti-1378	14	26	is	be	AUX
dti-1378	14	27	located	locate	VERB
dti-1378	14	28	on	on	ADP
dti-1378	14	29	the	the	DET
dti-1378	14	30	g3	g3	PROPN
dti-1378	14	31	box	box	NOUN
dti-1378	14	32	motif	motif	NOUN
dti-1378	14	33	and	and	CCONJ
dti-1378	14	34	ser53	ser53	NOUN
dti-1378	14	35	is	be	AUX
dti-1378	14	36	the	the	DET
dti-1378	14	37	binding	bind	VERB
dti-1378	14	38	residue	residue	NOUN
dti-1378	14	39	for	for	ADP
dti-1378	14	40	magnesium	magnesium	NOUN
dti-1378	14	41	ion	ion	NOUN
dti-1378	14	42	.	.	PUNCT
dti-1378	15	1	these	these	DET
dti-1378	15	2	findings	finding	NOUN
dti-1378	15	3	offer	offer	VERB
dti-1378	15	4	new	new	ADJ
dti-1378	15	5	insights	insight	NOUN
dti-1378	15	6	into	into	ADP
dti-1378	15	7	the	the	DET
dti-1378	15	8	dynamic	dynamic	ADJ
dti-1378	15	9	and	and	CCONJ
dti-1378	15	10	functional	functional	ADJ
dti-1378	15	11	determinants	determinant	NOUN
dti-1378	15	12	of	of	ADP
dti-1378	15	13	the	the	DET
dti-1378	15	14	smp_059340.1	smp_059340.1	PROPN
dti-1378	15	15	protein	protein	NOUN
dti-1378	15	16	in	in	ADP
dti-1378	15	17	regulating	regulate	VERB
dti-1378	15	18	the	the	DET
dti-1378	15	19	s.	s.	PROPN
dti-1378	15	20	mansoni	mansoni	PROPN
dti-1378	15	21	life	life	NOUN
dti-1378	15	22	cycle	cycle	NOUN
dti-1378	15	23	.	.	PUNCT
dti-1378	16	1	the	the	DET
dti-1378	16	2	binding	bind	VERB
dti-1378	16	3	interfaces	interface	NOUN
dti-1378	16	4	and	and	CCONJ
dti-1378	16	5	their	their	PRON
dti-1378	16	6	residues	residue	NOUN
dti-1378	16	7	could	could	AUX
dti-1378	16	8	be	be	AUX
dti-1378	16	9	used	use	VERB
dti-1378	16	10	as	as	ADP
dti-1378	16	11	starting	start	VERB
dti-1378	16	12	points	point	NOUN
dti-1378	16	13	for	for	ADP
dti-1378	16	14	selective	selective	ADJ
dti-1378	16	15	modulations	modulation	NOUN
dti-1378	16	16	of	of	ADP
dti-1378	16	17	interactions	interaction	NOUN
dti-1378	16	18	within	within	ADP
dti-1378	16	19	the	the	DET
dti-1378	16	20	pathway	pathway	NOUN
dti-1378	16	21	using	use	VERB
dti-1378	16	22	small	small	ADJ
dti-1378	16	23	molecules	molecule	NOUN
dti-1378	16	24	,	,	PUNCT
dti-1378	16	25	peptides	peptide	NOUN
dti-1378	16	26	or	or	CCONJ
dti-1378	16	27	mutagenesis	mutagenesis	NOUN
dti-1378	16	28	.	.	PUNCT
dti-1378	17	1	keywords	keyword	NOUN
dti-1378	17	2	:	:	PUNCT
dti-1378	17	3	adenylyl	adenylyl	NOUN
dti-1378	17	4	cyclase	cyclase	NOUN
dti-1378	17	5	pathway	pathway	NOUN
dti-1378	17	6	,	,	PUNCT
dti-1378	17	7	biomarkers	biomarker	NOUN
dti-1378	17	8	,	,	PUNCT
dti-1378	17	9	gtp	gtp	NOUN
dti-1378	17	10	binding	binding	NOUN
dti-1378	17	11	,	,	PUNCT
dti-1378	17	12	novel	novel	ADJ
dti-1378	17	13	drug	drug	NOUN
dti-1378	17	14	targets	target	NOUN
dti-1378	17	15	,	,	PUNCT
dti-1378	17	16	protein	protein	NOUN
dti-1378	17	17	domain	domain	NOUN
dti-1378	17	18	interactions	interaction	NOUN
dti-1378	17	19	,	,	PUNCT
dti-1378	17	20	pathway	pathway	NOUN
dti-1378	17	21	regulation	regulation	NOUN
dti-1378	17	22	,	,	PUNCT
dti-1378	17	23	schistosoma	schistosoma	PROPN
dti-1378	17	24	,	,	PUNCT
dti-1378	17	25	switch	switch	VERB
dti-1378	17	26	i	i	PRON
dti-1378	17	27	,	,	PUNCT
dti-1378	17	28	switch	switch	VERB
dti-1378	17	29	ii	ii	NOUN
dti-1378	17	30	http://dx.doi.org/10.4137/dti.s10219	http://dx.doi.org/10.4137/dti.s10219	ADJ
dti-1378	17	31	http://www.la-press.com	http://www.la-press.com	X
dti-1378	17	32	http://www.la-press.com	http://www.la-press.com	X
dti-1378	17	33	http://www.la-press.com/drug-target-insights-journal-j23	http://www.la-press.com/drug-target-insights-journal-j23	PROPN
dti-1378	17	34	http://www.la-press.com	http://www.la-press.com	X
dti-1378	17	35	mailto:raphael.isokpehi@jsums.edu	mailto:raphael.isokpehi@jsums.edu	PROPN
dti-1378	17	36	mbah	mbah	PROPN
dti-1378	17	37	et	et	PROPN
dti-1378	17	38	al	al	PROPN
dti-1378	17	39	42	42	NUM
dti-1378	17	40	drug	drug	NOUN
dti-1378	17	41	target	target	NOUN
dti-1378	17	42	insights	insight	NOUN
dti-1378	17	43	2012:6	2012:6	NUM
dti-1378	17	44	introduction	introduction	NOUN
dti-1378	17	45	schistosoma	schistosoma	ADJ
dti-1378	17	46	mansoni	mansoni	NOUN
dti-1378	17	47	(	(	PUNCT
dti-1378	17	48	s.	s.	PROPN
dti-1378	17	49	mansoni	mansoni	PROPN
dti-1378	17	50	)	)	PUNCT
dti-1378	17	51	is	be	AUX
dti-1378	17	52	a	a	DET
dti-1378	17	53	dioecious	dioecious	ADJ
dti-1378	17	54	trematode	trematode	NOUN
dti-1378	17	55	and	and	CCONJ
dti-1378	17	56	one	one	NUM
dti-1378	17	57	of	of	ADP
dti-1378	17	58	the	the	DET
dti-1378	17	59	etiologic	etiologic	ADJ
dti-1378	17	60	agents	agent	NOUN
dti-1378	17	61	of	of	ADP
dti-1378	17	62	schistosomiasis	schistosomiasis	NOUN
dti-1378	17	63	,	,	PUNCT
dti-1378	17	64	the	the	DET
dti-1378	17	65	second	second	ADJ
dti-1378	17	66	most	most	ADV
dti-1378	17	67	significant	significant	ADJ
dti-1378	17	68	tropical	tropical	ADJ
dti-1378	17	69	disease	disease	NOUN
dti-1378	17	70	after	after	ADP
dti-1378	17	71	malaria	malaria	NOUN
dti-1378	17	72	of	of	ADP
dti-1378	17	73	public	public	ADJ
dti-1378	17	74	health	health	NOUN
dti-1378	17	75	significance.1	significance.1	VERB
dti-1378	17	76	the	the	DET
dti-1378	17	77	endemicity	endemicity	NOUN
dti-1378	17	78	of	of	ADP
dti-1378	17	79	this	this	DET
dti-1378	17	80	neglected	neglect	VERB
dti-1378	17	81	tropical	tropical	ADJ
dti-1378	17	82	disease	disease	NOUN
dti-1378	17	83	of	of	ADP
dti-1378	17	84	poverty	poverty	NOUN
dti-1378	17	85	still	still	ADV
dti-1378	17	86	remains	remain	VERB
dti-1378	17	87	high	high	ADJ
dti-1378	17	88	with	with	ADP
dti-1378	17	89	about	about	ADV
dti-1378	17	90	200	200	NUM
dti-1378	17	91	million	million	NUM
dti-1378	17	92	people	people	NOUN
dti-1378	17	93	affected	affect	VERB
dti-1378	17	94	worldwide	worldwide	ADV
dti-1378	17	95	(	(	PUNCT
dti-1378	17	96	http://www.who.int/ctd/schisto/	http://www.who.int/ctd/schisto/	NOUN
dti-1378	17	97	epidemio.htm	epidemio.htm	X
dti-1378	17	98	)	)	PUNCT
dti-1378	17	99	.	.	PUNCT
dti-1378	18	1	the	the	DET
dti-1378	18	2	urinary	urinary	ADJ
dti-1378	18	3	manifestation	manifestation	NOUN
dti-1378	18	4	of	of	ADP
dti-1378	18	5	schistosomiasis	schistosomiasis	NOUN
dti-1378	18	6	can	can	AUX
dti-1378	18	7	become	become	VERB
dti-1378	18	8	bladder	bladder	NOUN
dti-1378	18	9	cancer.2	cancer.2	PROPN
dti-1378	18	10	praziquantel	praziquantel	PROPN
dti-1378	18	11	(	(	PUNCT
dti-1378	18	12	pzq	pzq	NOUN
dti-1378	18	13	)	)	PUNCT
dti-1378	18	14	is	be	AUX
dti-1378	18	15	the	the	DET
dti-1378	18	16	most	most	ADV
dti-1378	18	17	effective	effective	ADJ
dti-1378	18	18	and	and	CCONJ
dti-1378	18	19	acceptable	acceptable	ADJ
dti-1378	18	20	drug	drug	NOUN
dti-1378	18	21	against	against	ADP
dti-1378	18	22	schistosomiasis	schistosomiasis	NOUN
dti-1378	18	23	,	,	PUNCT
dti-1378	18	24	but	but	CCONJ
dti-1378	18	25	its	its	PRON
dti-1378	18	26	effectiveness	effectiveness	NOUN
dti-1378	18	27	is	be	AUX
dti-1378	18	28	limited	limit	VERB
dti-1378	18	29	due	due	ADP
dti-1378	18	30	to	to	ADP
dti-1378	18	31	its	its	PRON
dti-1378	18	32	inability	inability	NOUN
dti-1378	18	33	to	to	PART
dti-1378	18	34	kill	kill	VERB
dti-1378	18	35	parasite	parasite	NOUN
dti-1378	18	36	stages	stage	NOUN
dti-1378	18	37	within	within	ADP
dti-1378	18	38	2	2	NUM
dti-1378	18	39	to	to	PART
dti-1378	18	40	4	4	NUM
dti-1378	18	41	weeks	week	NOUN
dti-1378	18	42	post	post	ADJ
dti-1378	18	43	-	-	NOUN
dti-1378	18	44	infection	infection	NOUN
dti-1378	18	45	.	.	PUNCT
dti-1378	19	1	resistance	resistance	NOUN
dti-1378	19	2	to	to	ADP
dti-1378	19	3	praziquantel	praziquantel	PROPN
dti-1378	19	4	has	have	AUX
dti-1378	19	5	been	be	AUX
dti-1378	19	6	observed	observe	VERB
dti-1378	19	7	in	in	ADP
dti-1378	19	8	some	some	DET
dti-1378	19	9	s.	s.	PROPN
dti-1378	19	10	mansoni	mansoni	PROPN
dti-1378	19	11	isolates	isolate	NOUN
dti-1378	19	12	from	from	ADP
dti-1378	19	13	endemic	endemic	ADJ
dti-1378	19	14	regions	region	NOUN
dti-1378	19	15	in	in	ADP
dti-1378	19	16	africa.3,4	africa.3,4	ADJ
dti-1378	19	17	the	the	DET
dti-1378	19	18	availability	availability	NOUN
dti-1378	19	19	of	of	ADP
dti-1378	19	20	the	the	DET
dti-1378	19	21	draft	draft	NOUN
dti-1378	19	22	genome	genome	NOUN
dti-1378	19	23	sequence	sequence	NOUN
dti-1378	19	24	of	of	ADP
dti-1378	19	25	s.	s.	PROPN
dti-1378	19	26	mansoni5	mansoni5	PROPN
dti-1378	19	27	and	and	CCONJ
dti-1378	19	28	the	the	DET
dti-1378	19	29	wealth	wealth	NOUN
dti-1378	19	30	of	of	ADP
dti-1378	19	31	basic	basic	ADJ
dti-1378	19	32	molecular	molecular	ADJ
dti-1378	19	33	biology	biology	NOUN
dti-1378	19	34	research	research	NOUN
dti-1378	19	35	presents	present	VERB
dti-1378	19	36	new	new	ADJ
dti-1378	19	37	opportunities	opportunity	NOUN
dti-1378	19	38	to	to	PART
dti-1378	19	39	identify	identify	VERB
dti-1378	19	40	schistosome	schistosome	NOUN
dti-1378	19	41	protein	protein	NOUN
dti-1378	19	42	drug	drug	NOUN
dti-1378	19	43	targets	target	NOUN
dti-1378	19	44	,	,	PUNCT
dti-1378	19	45	and	and	CCONJ
dti-1378	19	46	to	to	PART
dti-1378	19	47	subsequently	subsequently	ADV
dti-1378	19	48	determine	determine	VERB
dti-1378	19	49	drug	drug	NOUN
dti-1378	19	50	exploitable	exploitable	ADJ
dti-1378	19	51	distinctive	distinctive	ADJ
dti-1378	19	52	protein	protein	NOUN
dti-1378	19	53	structural	structural	ADJ
dti-1378	19	54	features	feature	NOUN
dti-1378	19	55	.	.	PUNCT
dti-1378	20	1	the	the	DET
dti-1378	20	2	purpose	purpose	NOUN
dti-1378	20	3	of	of	ADP
dti-1378	20	4	the	the	DET
dti-1378	20	5	reported	report	VERB
dti-1378	20	6	research	research	NOUN
dti-1378	20	7	was	be	AUX
dti-1378	20	8	to	to	PART
dti-1378	20	9	determine	determine	VERB
dti-1378	20	10	drug	drug	NOUN
dti-1378	20	11	exploitable	exploitable	ADJ
dti-1378	20	12	distinctive	distinctive	ADJ
dti-1378	20	13	structural	structural	ADJ
dti-1378	20	14	features	feature	NOUN
dti-1378	20	15	of	of	ADP
dti-1378	20	16	the	the	DET
dti-1378	20	17	smp_058340.1	smp_058340.1	NOUN
dti-1378	20	18	protein	protein	NOUN
dti-1378	20	19	,	,	PUNCT
dti-1378	20	20	which	which	PRON
dti-1378	20	21	has	have	AUX
dti-1378	20	22	been	be	AUX
dti-1378	20	23	identified	identify	VERB
dti-1378	20	24	as	as	ADP
dti-1378	20	25	an	an	DET
dti-1378	20	26	attractive	attractive	ADJ
dti-1378	20	27	drug	drug	NOUN
dti-1378	20	28	target	target	NOUN
dti-1378	20	29	in	in	ADP
dti-1378	20	30	the	the	DET
dti-1378	20	31	s.	s.	PROPN
dti-1378	20	32	mansoni	mansoni	PROPN
dti-1378	20	33	genome.6	genome.6	AUX
dti-1378	20	34	the	the	DET
dti-1378	20	35	life	life	NOUN
dti-1378	20	36	cycle	cycle	NOUN
dti-1378	20	37	of	of	ADP
dti-1378	20	38	s.	s.	PROPN
dti-1378	20	39	mansoni	mansoni	PROPN
dti-1378	20	40	starts	start	VERB
dti-1378	20	41	with	with	ADP
dti-1378	20	42	the	the	DET
dti-1378	20	43	eggs	egg	NOUN
dti-1378	20	44	in	in	ADP
dti-1378	20	45	urine	urine	NOUN
dti-1378	20	46	or	or	CCONJ
dti-1378	20	47	feces	fece	NOUN
dti-1378	20	48	found	find	VERB
dti-1378	20	49	in	in	ADP
dti-1378	20	50	water	water	NOUN
dti-1378	20	51	,	,	PUNCT
dti-1378	20	52	which	which	PRON
dti-1378	20	53	then	then	ADV
dti-1378	20	54	hatch	hatch	VERB
dti-1378	20	55	to	to	PART
dti-1378	20	56	produce	produce	VERB
dti-1378	20	57	miracidia.7,8	miracidia.7,8	DET
dti-1378	20	58	the	the	DET
dti-1378	20	59	miracidia	miracidia	NOUN
dti-1378	20	60	will	will	AUX
dti-1378	20	61	eventually	eventually	ADV
dti-1378	20	62	penetrate	penetrate	VERB
dti-1378	20	63	the	the	DET
dti-1378	20	64	snail	snail	NOUN
dti-1378	20	65	tissue	tissue	NOUN
dti-1378	20	66	and	and	CCONJ
dti-1378	20	67	transform	transform	VERB
dti-1378	20	68	into	into	ADP
dti-1378	20	69	sporocysts	sporocyst	NOUN
dti-1378	20	70	.	.	PUNCT
dti-1378	21	1	the	the	DET
dti-1378	21	2	sporocysts	sporocyst	NOUN
dti-1378	21	3	in	in	ADP
dti-1378	21	4	the	the	DET
dti-1378	21	5	snail	snail	NOUN
dti-1378	21	6	will	will	AUX
dti-1378	21	7	develop	develop	VERB
dti-1378	21	8	into	into	ADP
dti-1378	21	9	cercariae	cercaria	NOUN
dti-1378	21	10	,	,	PUNCT
dti-1378	21	11	which	which	PRON
dti-1378	21	12	are	be	AUX
dti-1378	21	13	then	then	ADV
dti-1378	21	14	released	release	VERB
dti-1378	21	15	into	into	ADP
dti-1378	21	16	the	the	DET
dti-1378	21	17	water	water	NOUN
dti-1378	21	18	.	.	PUNCT
dti-1378	22	1	the	the	DET
dti-1378	22	2	cercaria	cercaria	NOUN
dti-1378	22	3	penetrates	penetrate	VERB
dti-1378	22	4	human	human	ADJ
dti-1378	22	5	skin	skin	NOUN
dti-1378	22	6	,	,	PUNCT
dti-1378	22	7	loses	lose	VERB
dti-1378	22	8	its	its	PRON
dti-1378	22	9	tail	tail	NOUN
dti-1378	22	10	during	during	ADP
dti-1378	22	11	this	this	DET
dti-1378	22	12	process	process	NOUN
dti-1378	22	13	,	,	PUNCT
dti-1378	22	14	and	and	CCONJ
dti-1378	22	15	transforms	transform	VERB
dti-1378	22	16	into	into	ADP
dti-1378	22	17	schistosomulum	schistosomulum	NOUN
dti-1378	22	18	.	.	PUNCT
dti-1378	23	1	schistosomulum	schistosomulum	NOUN
dti-1378	23	2	enters	enter	VERB
dti-1378	23	3	the	the	DET
dti-1378	23	4	blood	blood	NOUN
dti-1378	23	5	stream	stream	NOUN
dti-1378	23	6	and	and	CCONJ
dti-1378	23	7	migrates	migrate	VERB
dti-1378	23	8	to	to	ADP
dti-1378	23	9	the	the	DET
dti-1378	23	10	liver	liver	NOUN
dti-1378	23	11	,	,	PUNCT
dti-1378	23	12	bladder	bladder	NOUN
dti-1378	23	13	and	and	CCONJ
dti-1378	23	14	intestines	intestine	NOUN
dti-1378	23	15	and	and	CCONJ
dti-1378	23	16	matures	mature	NOUN
dti-1378	23	17	into	into	ADP
dti-1378	23	18	an	an	DET
dti-1378	23	19	adult	adult	NOUN
dti-1378	23	20	worm	worm	NOUN
dti-1378	23	21	.	.	PUNCT
dti-1378	24	1	the	the	DET
dti-1378	24	2	adults	adult	NOUN
dti-1378	24	3	mate	mate	VERB
dti-1378	24	4	and	and	CCONJ
dti-1378	24	5	produce	produce	VERB
dti-1378	24	6	eggs	egg	NOUN
dti-1378	24	7	,	,	PUNCT
dti-1378	24	8	which	which	PRON
dti-1378	24	9	are	be	AUX
dti-1378	24	10	released	release	VERB
dti-1378	24	11	from	from	ADP
dti-1378	24	12	the	the	DET
dti-1378	24	13	body	body	NOUN
dti-1378	24	14	through	through	ADP
dti-1378	24	15	urine	urine	NOUN
dti-1378	24	16	or	or	CCONJ
dti-1378	24	17	feces	fece	NOUN
dti-1378	24	18	to	to	PART
dti-1378	24	19	restart	restart	VERB
dti-1378	24	20	the	the	DET
dti-1378	24	21	life	life	NOUN
dti-1378	24	22	cycle.8	cycle.8	PROPN
dti-1378	24	23	during	during	ADP
dti-1378	24	24	this	this	DET
dti-1378	24	25	complex	complex	ADJ
dti-1378	24	26	developmental	developmental	ADJ
dti-1378	24	27	cycle	cycle	NOUN
dti-1378	24	28	in	in	ADP
dti-1378	24	29	the	the	DET
dti-1378	24	30	mammalian	mammalian	ADJ
dti-1378	24	31	host	host	NOUN
dti-1378	24	32	,	,	PUNCT
dti-1378	24	33	the	the	DET
dti-1378	24	34	juvenile	juvenile	ADJ
dti-1378	24	35	parasites	parasite	NOUN
dti-1378	24	36	pursue	pursue	VERB
dti-1378	24	37	a	a	DET
dti-1378	24	38	systematic	systematic	ADJ
dti-1378	24	39	and	and	CCONJ
dti-1378	24	40	complicated	complicated	ADJ
dti-1378	24	41	transition	transition	NOUN
dti-1378	24	42	that	that	PRON
dti-1378	24	43	goes	go	VERB
dti-1378	24	44	through	through	ADP
dti-1378	24	45	the	the	DET
dti-1378	24	46	heart	heart	NOUN
dti-1378	24	47	,	,	PUNCT
dti-1378	24	48	lungs	lung	NOUN
dti-1378	24	49	and	and	CCONJ
dti-1378	24	50	finally	finally	ADV
dti-1378	24	51	reaches	reach	VERB
dti-1378	24	52	the	the	DET
dti-1378	24	53	hepatic	hepatic	ADJ
dti-1378	24	54	portal	portal	ADJ
dti-1378	24	55	system	system	NOUN
dti-1378	24	56	,	,	PUNCT
dti-1378	24	57	which	which	PRON
dti-1378	24	58	is	be	AUX
dti-1378	24	59	the	the	DET
dti-1378	24	60	typical	typical	ADJ
dti-1378	24	61	residence	residence	NOUN
dti-1378	24	62	of	of	ADP
dti-1378	24	63	the	the	DET
dti-1378	24	64	adult	adult	NOUN
dti-1378	25	1	worm.8,9	worm.8,9	NOUN
dti-1378	25	2	this	this	DET
dti-1378	25	3	programmed	program	VERB
dti-1378	25	4	movement	movement	NOUN
dti-1378	25	5	is	be	AUX
dti-1378	25	6	essential	essential	ADJ
dti-1378	25	7	for	for	ADP
dti-1378	25	8	the	the	DET
dti-1378	25	9	continuous	continuous	ADJ
dti-1378	25	10	survival	survival	NOUN
dti-1378	25	11	of	of	ADP
dti-1378	25	12	the	the	DET
dti-1378	25	13	schistosome.9	schistosome.9	NOUN
dti-1378	25	14	furthermore	furthermore	ADV
dti-1378	25	15	,	,	PUNCT
dti-1378	25	16	the	the	DET
dti-1378	25	17	movement	movement	NOUN
dti-1378	25	18	is	be	AUX
dti-1378	25	19	highly	highly	ADV
dti-1378	25	20	coordinated	coordinate	VERB
dti-1378	25	21	by	by	ADP
dti-1378	25	22	both	both	CCONJ
dti-1378	25	23	the	the	DET
dti-1378	25	24	organism	organism	NOUN
dti-1378	25	25	’s	’s	PART
dti-1378	25	26	neuromuscular	neuromuscular	ADJ
dti-1378	25	27	system	system	NOUN
dti-1378	25	28	and	and	CCONJ
dti-1378	25	29	the	the	DET
dti-1378	25	30	participation	participation	NOUN
dti-1378	25	31	of	of	ADP
dti-1378	25	32	a	a	DET
dti-1378	25	33	host	host	NOUN
dti-1378	25	34	-	-	PUNCT
dti-1378	25	35	derived	derive	VERB
dti-1378	25	36	signal	signal	NOUN
dti-1378	25	37	(	(	PUNCT
dti-1378	25	38	serotonin	serotonin	NOUN
dti-1378	25	39	(	(	PUNCT
dti-1378	25	40	5	5	NUM
dti-1378	25	41	-	-	PUNCT
dti-1378	25	42	hydroxytryptamine	hydroxytryptamine	NOUN
dti-1378	25	43	:	:	PUNCT
dti-1378	25	44	5ht	5ht	NUM
dti-1378	25	45	)	)	PUNCT
dti-1378	25	46	that	that	PRON
dti-1378	25	47	modulates	modulate	VERB
dti-1378	25	48	schistosome	schistosome	VERB
dti-1378	25	49	motility.9,10	motility.9,10	PROPN
dti-1378	25	50	schistosoma	schistosoma	ADJ
dti-1378	25	51	species	specie	NOUN
dti-1378	25	52	have	have	AUX
dti-1378	25	53	been	be	AUX
dti-1378	25	54	documented	document	VERB
dti-1378	25	55	to	to	PART
dti-1378	25	56	take	take	VERB
dti-1378	25	57	up	up	ADP
dti-1378	25	58	5ht	5ht	ADV
dti-1378	25	59	from	from	ADP
dti-1378	25	60	their	their	PRON
dti-1378	25	61	immediate	immediate	ADJ
dti-1378	25	62	host	host	NOUN
dti-1378	25	63	circulatory	circulatory	ADJ
dti-1378	25	64	system	system	NOUN
dti-1378	25	65	through	through	ADP
dti-1378	25	66	a	a	DET
dti-1378	25	67	transporter	transporter	NOUN
dti-1378	25	68	-	-	PUNCT
dti-1378	25	69	mediated	mediate	VERB
dti-1378	25	70	mechanism.11,12	mechanism.11,12	NOUN
dti-1378	25	71	this	this	DET
dti-1378	25	72	carrier	carrier	NOUN
dti-1378	25	73	mechanism	mechanism	NOUN
dti-1378	25	74	is	be	AUX
dti-1378	25	75	thought	think	VERB
dti-1378	25	76	to	to	PART
dti-1378	25	77	contribute	contribute	VERB
dti-1378	25	78	massively	massively	ADV
dti-1378	25	79	to	to	ADP
dti-1378	25	80	the	the	DET
dti-1378	25	81	control	control	NOUN
dti-1378	25	82	of	of	ADP
dti-1378	25	83	the	the	DET
dti-1378	25	84	schistosome	schistosome	NOUN
dti-1378	25	85	motility	motility	NOUN
dti-1378	25	86	in	in	ADP
dti-1378	25	87	the	the	DET
dti-1378	25	88	host	host	NOUN
dti-1378	25	89	blood	blood	NOUN
dti-1378	25	90	system	system	NOUN
dti-1378	25	91	and	and	CCONJ
dti-1378	25	92	is	be	AUX
dti-1378	25	93	very	very	ADV
dti-1378	25	94	essential	essential	ADJ
dti-1378	25	95	for	for	ADP
dti-1378	25	96	the	the	DET
dti-1378	25	97	continuous	continuous	ADJ
dti-1378	25	98	survival	survival	NOUN
dti-1378	25	99	of	of	ADP
dti-1378	25	100	the	the	DET
dti-1378	25	101	parasite9,13	parasite9,13	NOUN
dti-1378	25	102	and	and	CCONJ
dti-1378	25	103	thus	thus	ADV
dti-1378	25	104	its	its	PRON
dti-1378	25	105	pathogenicity	pathogenicity	NOUN
dti-1378	25	106	.	.	PUNCT
dti-1378	26	1	the	the	DET
dti-1378	26	2	effects	effect	NOUN
dti-1378	26	3	of	of	ADP
dti-1378	26	4	serotonin	serotonin	NOUN
dti-1378	26	5	have	have	AUX
dti-1378	26	6	been	be	AUX
dti-1378	26	7	extensively	extensively	ADV
dti-1378	26	8	studied	study	VERB
dti-1378	26	9	in	in	ADP
dti-1378	26	10	some	some	DET
dti-1378	26	11	members	member	NOUN
dti-1378	26	12	of	of	ADP
dti-1378	26	13	the	the	DET
dti-1378	26	14	platyhelminthes	platyhelminthe	NOUN
dti-1378	26	15	group	group	NOUN
dti-1378	26	16	such	such	ADJ
dti-1378	26	17	as	as	ADP
dti-1378	26	18	hymenolepis	hymenolepis	NOUN
dti-1378	26	19	diminuta9,14	diminuta9,14	ADV
dti-1378	26	20	and	and	CCONJ
dti-1378	26	21	s.	s.	PROPN
dti-1378	26	22	mansoni.9,15,16	mansoni.9,15,16	PROPN
dti-1378	26	23	serotonin	serotonin	VERB
dti-1378	26	24	alters	alter	VERB
dti-1378	26	25	the	the	DET
dti-1378	26	26	parasite	parasite	NOUN
dti-1378	26	27	muscular	muscular	ADJ
dti-1378	26	28	tone,10	tone,10	NOUN
dti-1378	26	29	strength12	strength12	NOUN
dti-1378	26	30	and	and	CCONJ
dti-1378	26	31	carbohydrate	carbohydrate	VERB
dti-1378	26	32	metabolism.14,17,18	metabolism.14,17,18	PROPN
dti-1378	26	33	in	in	ADP
dti-1378	26	34	the	the	DET
dti-1378	26	35	intramolluscan	intramolluscan	PROPN
dti-1378	26	36	larval	larval	NOUN
dti-1378	26	37	stages	stage	NOUN
dti-1378	26	38	,	,	PUNCT
dti-1378	26	39	serotonin	serotonin	NOUN
dti-1378	26	40	elevates	elevate	VERB
dti-1378	26	41	the	the	DET
dti-1378	26	42	muscular	muscular	ADJ
dti-1378	26	43	activity	activity	NOUN
dti-1378	26	44	of	of	ADP
dti-1378	26	45	the	the	DET
dti-1378	26	46	mother	mother	NOUN
dti-1378	26	47	sporocysts	sporocyst	NOUN
dti-1378	26	48	of	of	ADP
dti-1378	26	49	s.	s.	PROPN
dti-1378	26	50	mansoni,12	mansoni,12	PROPN
dti-1378	26	51	leading	lead	VERB
dti-1378	26	52	to	to	ADP
dti-1378	26	53	stimulation	stimulation	NOUN
dti-1378	26	54	and	and	CCONJ
dti-1378	26	55	release	release	NOUN
dti-1378	26	56	of	of	ADP
dti-1378	26	57	the	the	DET
dti-1378	26	58	daughter	daughter	NOUN
dti-1378	26	59	sporocysts19	sporocysts19	VERB
dti-1378	26	60	and	and	CCONJ
dti-1378	26	61	eliciting	elicit	VERB
dti-1378	26	62	turning	turn	VERB
dti-1378	26	63	behavior	behavior	NOUN
dti-1378	26	64	in	in	ADP
dti-1378	26	65	miracidia.20	miracidia.20	NOUN
dti-1378	26	66	the	the	DET
dti-1378	26	67	5ht	5ht	NOUN
dti-1378	26	68	binds	bind	VERB
dti-1378	26	69	directly	directly	ADV
dti-1378	26	70	to	to	ADP
dti-1378	26	71	the	the	DET
dti-1378	26	72	exposed	expose	VERB
dti-1378	26	73	surface	surface	NOUN
dti-1378	26	74	5ht	5ht	ADJ
dti-1378	26	75	receptor	receptor	NOUN
dti-1378	26	76	(	(	PUNCT
dti-1378	26	77	smp_126730	smp_126730	NUM
dti-1378	26	78	)	)	PUNCT
dti-1378	26	79	on	on	ADP
dti-1378	26	80	the	the	DET
dti-1378	26	81	parasite	parasite	NOUN
dti-1378	26	82	muscles	muscle	NOUN
dti-1378	26	83	and	and	CCONJ
dti-1378	26	84	then	then	ADV
dti-1378	26	85	activates	activate	VERB
dti-1378	26	86	adenylyl	adenylyl	ADJ
dti-1378	26	87	cyclase	cyclase	NOUN
dti-1378	26	88	activity	activity	NOUN
dti-1378	26	89	,	,	PUNCT
dti-1378	26	90	whose	whose	DET
dti-1378	26	91	main	main	ADJ
dti-1378	26	92	function	function	NOUN
dti-1378	26	93	is	be	AUX
dti-1378	26	94	the	the	DET
dti-1378	26	95	regulation	regulation	NOUN
dti-1378	26	96	of	of	ADP
dti-1378	26	97	cyclic	cyclic	ADJ
dti-1378	26	98	adenosine	adenosine	NOUN
dti-1378	26	99	monophosphate	monophosphate	NOUN
dti-1378	26	100	(	(	PUNCT
dti-1378	26	101	camp	camp	NOUN
dti-1378	26	102	)	)	PUNCT
dti-1378	26	103	of	of	ADP
dti-1378	26	104	the	the	DET
dti-1378	26	105	anaerobic	anaerobic	NOUN
dti-1378	26	106	glycolysis	glycolysis	NOUN
dti-1378	26	107	pathway	pathway	NOUN
dti-1378	26	108	.	.	PUNCT
dti-1378	27	1	this	this	DET
dti-1378	27	2	metabolic	metabolic	NOUN
dti-1378	27	3	pathway	pathway	NOUN
dti-1378	27	4	is	be	AUX
dti-1378	27	5	the	the	DET
dti-1378	27	6	main	main	ADJ
dti-1378	27	7	source	source	NOUN
dti-1378	27	8	of	of	ADP
dti-1378	27	9	energy	energy	NOUN
dti-1378	27	10	in	in	ADP
dti-1378	27	11	the	the	DET
dti-1378	27	12	parasite.7,8,14	parasite.7,8,14	NOUN
dti-1378	27	13	the	the	DET
dti-1378	27	14	binding	binding	NOUN
dti-1378	27	15	of	of	ADP
dti-1378	27	16	guanosine	guanosine	NOUN
dti-1378	27	17	triphosphate	triphosphate	NOUN
dti-1378	27	18	(	(	PUNCT
dti-1378	27	19	gtp	gtp	NOUN
dti-1378	27	20	)	)	PUNCT
dti-1378	27	21	to	to	ADP
dti-1378	27	22	the	the	DET
dti-1378	27	23	s.	s.	PROPN
dti-1378	27	24	mansoni	mansoni	PROPN
dti-1378	27	25	5ht	5ht	ADJ
dti-1378	27	26	receptor	receptor	NOUN
dti-1378	27	27	smp_126730	smp_126730	NUM
dti-1378	27	28	is	be	AUX
dti-1378	27	29	necessary	necessary	ADJ
dti-1378	27	30	for	for	ADP
dti-1378	27	31	serotonin	serotonin	NOUN
dti-1378	27	32	activation.21	activation.21	NOUN
dti-1378	27	33	the	the	DET
dti-1378	27	34	adult	adult	NOUN
dti-1378	27	35	stage	stage	NOUN
dti-1378	27	36	of	of	ADP
dti-1378	27	37	the	the	DET
dti-1378	27	38	parasite	parasite	NOUN
dti-1378	27	39	has	have	VERB
dti-1378	27	40	the	the	DET
dti-1378	27	41	highest	high	ADJ
dti-1378	27	42	adenylyl	adenylyl	ADJ
dti-1378	27	43	cyclase	cyclase	NOUN
dti-1378	27	44	activity	activity	NOUN
dti-1378	27	45	,	,	PUNCT
dti-1378	27	46	while	while	SCONJ
dti-1378	27	47	the	the	DET
dti-1378	27	48	cercariae	cercaria	NOUN
dti-1378	27	49	stage	stage	NOUN
dti-1378	27	50	has	have	VERB
dti-1378	27	51	a	a	DET
dti-1378	27	52	very	very	ADV
dti-1378	27	53	low	low	ADJ
dti-1378	27	54	adenylyl	adenylyl	NOUN
dti-1378	27	55	cyclase	cyclase	NOUN
dti-1378	27	56	activity,22	activity,22	NOUN
dti-1378	27	57	and	and	CCONJ
dti-1378	27	58	the	the	DET
dti-1378	27	59	schistosomula	schistosomula	NOUN
dti-1378	27	60	activation	activation	NOUN
dti-1378	27	61	is	be	AUX
dti-1378	27	62	comparable	comparable	ADJ
dti-1378	27	63	to	to	ADP
dti-1378	27	64	that	that	PRON
dti-1378	27	65	of	of	ADP
dti-1378	27	66	the	the	DET
dti-1378	27	67	adult	adult	NOUN
dti-1378	27	68	parasite.23	parasite.23	PROPN
dti-1378	27	69	the	the	DET
dti-1378	27	70	serotonin	serotonin	NOUN
dti-1378	27	71	receptor	receptor	NOUN
dti-1378	27	72	undergoes	undergo	VERB
dti-1378	27	73	a	a	DET
dti-1378	27	74	series	series	NOUN
dti-1378	27	75	of	of	ADP
dti-1378	27	76	activated	activate	VERB
dti-1378	27	77	pathways	pathway	NOUN
dti-1378	27	78	while	while	SCONJ
dti-1378	27	79	carrying	carry	VERB
dti-1378	27	80	out	out	ADP
dti-1378	27	81	its	its	PRON
dti-1378	27	82	function	function	NOUN
dti-1378	27	83	.	.	PUNCT
dti-1378	28	1	the	the	DET
dti-1378	28	2	receptor	receptor	NOUN
dti-1378	28	3	activated	activate	VERB
dti-1378	28	4	g	g	NOUN
dti-1378	28	5	proteins	protein	NOUN
dti-1378	28	6	are	be	AUX
dti-1378	28	7	bounded	bound	VERB
dti-1378	28	8	to	to	ADP
dti-1378	28	9	the	the	DET
dti-1378	28	10	inner	inner	ADJ
dti-1378	28	11	surface	surface	NOUN
dti-1378	28	12	of	of	ADP
dti-1378	28	13	the	the	DET
dti-1378	28	14	cell	cell	NOUN
dti-1378	28	15	membrane	membrane	NOUN
dti-1378	28	16	.	.	PUNCT
dti-1378	29	1	generally	generally	ADV
dti-1378	29	2	,	,	PUNCT
dti-1378	29	3	g	g	PROPN
dti-1378	29	4	proteins	protein	NOUN
dti-1378	29	5	are	be	AUX
dti-1378	29	6	known	know	VERB
dti-1378	29	7	to	to	PART
dti-1378	29	8	serve	serve	VERB
dti-1378	29	9	as	as	ADP
dti-1378	29	10	mediators	mediator	NOUN
dti-1378	29	11	between	between	ADP
dti-1378	29	12	signal	signal	NOUN
dti-1378	29	13	receptors	receptor	NOUN
dti-1378	29	14	and	and	CCONJ
dti-1378	29	15	effector	effector	NOUN
dti-1378	29	16	enzymes	enzyme	NOUN
dti-1378	29	17	.	.	PUNCT
dti-1378	30	1	as	as	ADP
dti-1378	30	2	such	such	ADJ
dti-1378	30	3	,	,	PUNCT
dti-1378	30	4	they	they	PRON
dti-1378	30	5	are	be	AUX
dti-1378	30	6	regarded	regard	VERB
dti-1378	30	7	as	as	ADP
dti-1378	30	8	regulator	regulator	NOUN
dti-1378	30	9	of	of	ADP
dti-1378	30	10	metabolic	metabolic	NOUN
dti-1378	30	11	pathways	pathway	NOUN
dti-1378	30	12	.	.	PUNCT
dti-1378	31	1	the	the	DET
dti-1378	31	2	g	g	PROPN
dti-1378	31	3	protein	protein	NOUN
dti-1378	31	4	complex	complex	NOUN
dti-1378	31	5	is	be	AUX
dti-1378	31	6	made	make	VERB
dti-1378	31	7	up	up	ADP
dti-1378	31	8	of	of	ADP
dti-1378	31	9	the	the	DET
dti-1378	31	10	gα	gα	NOUN
dti-1378	31	11	and	and	CCONJ
dti-1378	31	12	the	the	DET
dti-1378	31	13	gβγ	gβγ	NOUN
dti-1378	31	14	subunits	subunit	NOUN
dti-1378	31	15	and	and	CCONJ
dti-1378	31	16	subunit	subunit	NOUN
dti-1378	31	17	has	have	VERB
dti-1378	31	18	a	a	DET
dti-1378	31	19	functional	functional	ADJ
dti-1378	31	20	role	role	NOUN
dti-1378	31	21	in	in	ADP
dti-1378	31	22	controlling	control	VERB
dti-1378	31	23	the	the	DET
dti-1378	31	24	activity	activity	NOUN
dti-1378	31	25	of	of	ADP
dti-1378	31	26	adenylyl	adenylyl	NOUN
dti-1378	31	27	cyclase	cyclase	NOUN
dti-1378	31	28	.	.	PUNCT
dti-1378	32	1	the	the	DET
dti-1378	32	2	gα	gα	NOUN
dti-1378	32	3	is	be	AUX
dti-1378	32	4	further	far	ADV
dti-1378	32	5	divided	divide	VERB
dti-1378	32	6	into	into	ADP
dti-1378	32	7	4	4	NUM
dti-1378	32	8	subclasses	subclass	NOUN
dti-1378	32	9	:	:	PUNCT
dti-1378	32	10	gαs	gαs	PROPN
dti-1378	32	11	,	,	PUNCT
dti-1378	32	12	gαi	gαi	NOUN
dti-1378	32	13	,	,	PUNCT
dti-1378	32	14	gαq/11	gαq/11	NOUN
dti-1378	32	15	,	,	PUNCT
dti-1378	32	16	and	and	CCONJ
dti-1378	32	17	gα12/13	gα12/13	NOUN
dti-1378	32	18	.	.	PUNCT
dti-1378	33	1	the	the	DET
dti-1378	33	2	gαs	gαs	PROPN
dti-1378	33	3	subclass	subclass	NOUN
dti-1378	33	4	is	be	AUX
dti-1378	33	5	the	the	DET
dti-1378	33	6	g	g	PROPN
dti-1378	33	7	protein	protein	NOUN
dti-1378	33	8	component	component	NOUN
dti-1378	33	9	responsible	responsible	ADJ
dti-1378	33	10	for	for	ADP
dti-1378	33	11	regulating	regulate	VERB
dti-1378	33	12	the	the	DET
dti-1378	33	13	adenylyl	adenylyl	NOUN
dti-1378	33	14	cyclase	cyclase	NOUN
dti-1378	33	15	activity	activity	NOUN
dti-1378	33	16	pathway	pathway	NOUN
dti-1378	33	17	in	in	ADP
dti-1378	33	18	s.	s.	PROPN
dti-1378	33	19	mansoni	mansoni	PROPN
dti-1378	33	20	.	.	PUNCT
dti-1378	34	1	the	the	DET
dti-1378	34	2	binding	binding	NOUN
dti-1378	34	3	of	of	ADP
dti-1378	34	4	serotonin	serotonin	NOUN
dti-1378	34	5	to	to	ADP
dti-1378	34	6	the	the	DET
dti-1378	34	7	extracellular	extracellular	ADJ
dti-1378	34	8	receptor	receptor	NOUN
dti-1378	34	9	triggers	trigger	VERB
dti-1378	34	10	the	the	DET
dti-1378	34	11	release	release	NOUN
dti-1378	34	12	of	of	ADP
dti-1378	34	13	gdp	gdp	NOUN
dti-1378	34	14	from	from	ADP
dti-1378	34	15	the	the	DET
dti-1378	34	16	gαs	gαs	PROPN
dti-1378	34	17	subunit	subunit	NOUN
dti-1378	34	18	and	and	CCONJ
dti-1378	34	19	http://www.la-press.com	http://www.la-press.com	X
dti-1378	35	1	http://www.who.int/ctd/schisto/epidemio.htm	http://www.who.int/ctd/schisto/epidemio.htm	DET
dti-1378	35	2	drug	drug	NOUN
dti-1378	35	3	target	target	NOUN
dti-1378	35	4	features	feature	NOUN
dti-1378	35	5	of	of	ADP
dti-1378	35	6	schistosoma	schistosoma	ADJ
dti-1378	35	7	adenylyl	adenylyl	NOUN
dti-1378	35	8	cyclase	cyclase	NOUN
dti-1378	35	9	activity	activity	NOUN
dti-1378	35	10	drug	drug	NOUN
dti-1378	35	11	target	target	NOUN
dti-1378	35	12	insights	insight	NOUN
dti-1378	35	13	2012:6	2012:6	NUM
dti-1378	35	14	43	43	NUM
dti-1378	35	15	initiates	initiate	VERB
dti-1378	35	16	the	the	DET
dti-1378	35	17	binding	binding	NOUN
dti-1378	35	18	of	of	ADP
dti-1378	35	19	gtp.24	gtp.24	NOUN
dti-1378	36	1	this	this	PRON
dti-1378	36	2	serotonin	serotonin	VERB
dti-1378	36	3	binding	bind	VERB
dti-1378	36	4	causes	cause	VERB
dti-1378	36	5	the	the	DET
dti-1378	36	6	gβγ	gβγ	NOUN
dti-1378	36	7	complex	complex	NOUN
dti-1378	36	8	to	to	PART
dti-1378	36	9	dissociate	dissociate	VERB
dti-1378	36	10	from	from	ADP
dti-1378	36	11	the	the	DET
dti-1378	36	12	gαsgtp	gαsgtp	NOUN
dti-1378	36	13	complex	complex	NOUN
dti-1378	36	14	.	.	PUNCT
dti-1378	37	1	the	the	DET
dti-1378	37	2	activated	activate	VERB
dti-1378	37	3	gαs	gαs	NOUN
dti-1378	37	4	can	can	AUX
dti-1378	37	5	stimulate	stimulate	VERB
dti-1378	37	6	the	the	DET
dti-1378	37	7	adenylyl	adenylyl	NOUN
dti-1378	37	8	cyclase	cyclase	NOUN
dti-1378	37	9	activity	activity	NOUN
dti-1378	37	10	,	,	PUNCT
dti-1378	37	11	while	while	SCONJ
dti-1378	37	12	the	the	DET
dti-1378	37	13	gβγ	gβγ	NOUN
dti-1378	37	14	complexes	complex	NOUN
dti-1378	37	15	can	can	AUX
dti-1378	37	16	either	either	CCONJ
dti-1378	37	17	stimulate	stimulate	VERB
dti-1378	37	18	or	or	CCONJ
dti-1378	37	19	inhibit	inhibit	VERB
dti-1378	37	20	it	it	PRON
dti-1378	37	21	.	.	PUNCT
dti-1378	38	1	the	the	DET
dti-1378	38	2	gαs	gαs	PROPN
dti-1378	38	3	-	-	PUNCT
dti-1378	38	4	gtp	gtp	NOUN
dti-1378	38	5	complex	complex	NOUN
dti-1378	38	6	will	will	AUX
dti-1378	38	7	stimulate	stimulate	VERB
dti-1378	38	8	the	the	DET
dti-1378	38	9	adenylyl	adenylyl	NOUN
dti-1378	38	10	cyclase	cyclase	NOUN
dti-1378	38	11	activity	activity	NOUN
dti-1378	38	12	through	through	ADP
dti-1378	38	13	the	the	DET
dti-1378	38	14	enzyme	enzyme	NOUN
dti-1378	38	15	binding	bind	VERB
dti-1378	38	16	site	site	NOUN
dti-1378	38	17	of	of	ADP
dti-1378	38	18	the	the	DET
dti-1378	38	19	gαs	gαs	PROPN
dti-1378	38	20	protein	protein	NOUN
dti-1378	38	21	.	.	PUNCT
dti-1378	39	1	the	the	DET
dti-1378	39	2	adenylyl	adenylyl	NOUN
dti-1378	39	3	cyclase	cyclase	NOUN
dti-1378	39	4	activity	activity	NOUN
dti-1378	39	5	will	will	AUX
dti-1378	39	6	finally	finally	ADV
dti-1378	39	7	lead	lead	VERB
dti-1378	39	8	to	to	ADP
dti-1378	39	9	the	the	DET
dti-1378	39	10	production	production	NOUN
dti-1378	39	11	of	of	ADP
dti-1378	39	12	camp	camp	NOUN
dti-1378	39	13	from	from	ADP
dti-1378	39	14	atp	atp	PROPN
dti-1378	39	15	.	.	PUNCT
dti-1378	40	1	the	the	DET
dti-1378	40	2	process	process	NOUN
dti-1378	40	3	involves	involve	VERB
dti-1378	40	4	removing	remove	VERB
dti-1378	40	5	the	the	DET
dti-1378	40	6	pyrophosphatase	pyrophosphatase	NOUN
dti-1378	40	7	group	group	NOUN
dti-1378	40	8	from	from	ADP
dti-1378	40	9	atp	atp	PROPN
dti-1378	40	10	.	.	PUNCT
dti-1378	41	1	this	this	DET
dti-1378	41	2	metabolic	metabolic	NOUN
dti-1378	41	3	pathway	pathway	NOUN
dti-1378	41	4	is	be	AUX
dti-1378	41	5	the	the	DET
dti-1378	41	6	main	main	ADJ
dti-1378	41	7	source	source	NOUN
dti-1378	41	8	of	of	ADP
dti-1378	41	9	energy	energy	NOUN
dti-1378	41	10	in	in	ADP
dti-1378	41	11	the	the	DET
dti-1378	41	12	s.	s.	PROPN
dti-1378	41	13	mansoni	mansoni	PROPN
dti-1378	41	14	throughout	throughout	ADP
dti-1378	41	15	its	its	PRON
dti-1378	41	16	developmental	developmental	NOUN
dti-1378	41	17	stages.7,8,14	stages.7,8,14	ADV
dti-1378	41	18	the	the	DET
dti-1378	41	19	gtp	gtp	NOUN
dti-1378	41	20	-	-	PUNCT
dti-1378	41	21	binding	bind	VERB
dti-1378	41	22	protein	protein	NOUN
dti-1378	41	23	smp_059340.1	smp_059340.1	PROPN
dti-1378	41	24	has	have	AUX
dti-1378	41	25	been	be	AUX
dti-1378	41	26	identified	identify	VERB
dti-1378	41	27	as	as	ADP
dti-1378	41	28	an	an	DET
dti-1378	41	29	attractive	attractive	ADJ
dti-1378	41	30	drug	drug	NOUN
dti-1378	41	31	target	target	NOUN
dti-1378	41	32	in	in	ADP
dti-1378	41	33	the	the	DET
dti-1378	41	34	s.	s.	PROPN
dti-1378	41	35	mansoni	mansoni	PROPN
dti-1378	41	36	genome.6	genome.6	AUX
dti-1378	41	37	the	the	DET
dti-1378	41	38	availability	availability	NOUN
dti-1378	41	39	of	of	ADP
dti-1378	41	40	diverse	diverse	ADJ
dti-1378	41	41	structural	structural	ADJ
dti-1378	41	42	bioinformatics	bioinformatics	NOUN
dti-1378	41	43	tools	tool	NOUN
dti-1378	41	44	provides	provide	VERB
dti-1378	41	45	opportunities	opportunity	NOUN
dti-1378	41	46	to	to	PART
dti-1378	41	47	determine	determine	VERB
dti-1378	41	48	the	the	DET
dti-1378	41	49	structure	structure	NOUN
dti-1378	41	50	-	-	PUNCT
dti-1378	41	51	function	function	NOUN
dti-1378	41	52	relationship	relationship	NOUN
dti-1378	41	53	of	of	ADP
dti-1378	41	54	the	the	DET
dti-1378	41	55	smp_059340.1	smp_059340.1	PROPN
dti-1378	41	56	.	.	PUNCT
dti-1378	42	1	the	the	DET
dti-1378	42	2	g	g	PROPN
dti-1378	42	3	(	(	PUNCT
dti-1378	42	4	gtp	gtp	NOUN
dti-1378	42	5	binding	binding	ADJ
dti-1378	42	6	)	)	PUNCT
dti-1378	42	7	proteins	protein	NOUN
dti-1378	42	8	have	have	VERB
dti-1378	42	9	fingerprints	fingerprint	NOUN
dti-1378	42	10	called	call	VERB
dti-1378	42	11	consensus	consensus	NOUN
dti-1378	42	12	sequences	sequence	NOUN
dti-1378	42	13	(	(	PUNCT
dti-1378	42	14	g	g	NOUN
dti-1378	42	15	motifs	motif	NOUN
dti-1378	42	16	)	)	PUNCT
dti-1378	42	17	that	that	PRON
dti-1378	42	18	have	have	AUX
dti-1378	42	19	served	serve	VERB
dti-1378	42	20	as	as	ADP
dti-1378	42	21	valuable	valuable	ADJ
dti-1378	42	22	tools	tool	NOUN
dti-1378	42	23	in	in	ADP
dti-1378	42	24	their	their	PRON
dti-1378	42	25	identification	identification	NOUN
dti-1378	42	26	.	.	PUNCT
dti-1378	43	1	however	however	ADV
dti-1378	43	2	,	,	PUNCT
dti-1378	43	3	any	any	DET
dti-1378	43	4	subtle	subtle	ADJ
dti-1378	43	5	change	change	NOUN
dti-1378	43	6	in	in	ADP
dti-1378	43	7	these	these	DET
dti-1378	43	8	consensus	consensus	NOUN
dti-1378	43	9	sequences	sequence	NOUN
dti-1378	43	10	will	will	AUX
dti-1378	43	11	be	be	AUX
dti-1378	43	12	reflected	reflect	VERB
dti-1378	43	13	in	in	ADP
dti-1378	43	14	functional	functional	ADJ
dti-1378	43	15	differences	difference	NOUN
dti-1378	43	16	among	among	ADP
dti-1378	43	17	these	these	DET
dti-1378	43	18	proteins	protein	NOUN
dti-1378	43	19	.	.	PUNCT
dti-1378	44	1	it	it	PRON
dti-1378	44	2	is	be	AUX
dti-1378	44	3	therefore	therefore	ADV
dti-1378	44	4	very	very	ADV
dti-1378	44	5	important	important	ADJ
dti-1378	44	6	to	to	PART
dti-1378	44	7	determine	determine	VERB
dti-1378	44	8	the	the	DET
dti-1378	44	9	distinctive	distinctive	ADJ
dti-1378	44	10	structural	structural	ADJ
dti-1378	44	11	features	feature	NOUN
dti-1378	44	12	of	of	ADP
dti-1378	44	13	the	the	DET
dti-1378	44	14	smp_059340.1	smp_059340.1	PROPN
dti-1378	44	15	protein	protein	NOUN
dti-1378	44	16	that	that	PRON
dti-1378	44	17	map	map	NOUN
dti-1378	44	18	to	to	ADP
dti-1378	44	19	its	its	PRON
dti-1378	44	20	biological	biological	ADJ
dti-1378	44	21	function	function	NOUN
dti-1378	44	22	in	in	ADP
dti-1378	44	23	s.	s.	PROPN
dti-1378	44	24	mansoni	mansoni	PROPN
dti-1378	44	25	.	.	PUNCT
dti-1378	45	1	the	the	DET
dti-1378	45	2	purpose	purpose	NOUN
dti-1378	45	3	of	of	ADP
dti-1378	45	4	the	the	DET
dti-1378	45	5	reported	report	VERB
dti-1378	45	6	research	research	NOUN
dti-1378	45	7	investigation	investigation	NOUN
dti-1378	45	8	was	be	AUX
dti-1378	45	9	to	to	PART
dti-1378	45	10	determine	determine	VERB
dti-1378	45	11	the	the	DET
dti-1378	45	12	distinctive	distinctive	ADJ
dti-1378	45	13	structural	structural	ADJ
dti-1378	45	14	features	feature	NOUN
dti-1378	45	15	regulating	regulate	VERB
dti-1378	45	16	the	the	DET
dti-1378	45	17	functioning	functioning	NOUN
dti-1378	45	18	of	of	ADP
dti-1378	45	19	smp_059340.1	smp_059340.1	PROPN
dti-1378	45	20	protein	protein	NOUN
dti-1378	45	21	at	at	ADP
dti-1378	45	22	the	the	DET
dti-1378	45	23	molecular	molecular	ADJ
dti-1378	45	24	level	level	NOUN
dti-1378	45	25	.	.	PUNCT
dti-1378	46	1	we	we	PRON
dti-1378	46	2	hypothesized	hypothesize	VERB
dti-1378	46	3	that	that	SCONJ
dti-1378	46	4	determining	determine	VERB
dti-1378	46	5	the	the	DET
dti-1378	46	6	physicochemical	physicochemical	ADJ
dti-1378	46	7	features	feature	NOUN
dti-1378	46	8	and	and	CCONJ
dti-1378	46	9	conserved	conserve	VERB
dti-1378	46	10	protein	protein	NOUN
dti-1378	46	11	domain	domain	NOUN
dti-1378	46	12	organization	organization	NOUN
dti-1378	46	13	of	of	ADP
dti-1378	46	14	the	the	DET
dti-1378	46	15	s.	s.	PROPN
dti-1378	46	16	mansoni	mansoni	PROPN
dti-1378	46	17	smp_059340.1	smp_059340.1	PROPN
dti-1378	46	18	protein	protein	NOUN
dti-1378	46	19	would	would	AUX
dti-1378	46	20	help	help	VERB
dti-1378	46	21	identify	identify	VERB
dti-1378	46	22	putative	putative	ADJ
dti-1378	46	23	new	new	ADJ
dti-1378	46	24	functional	functional	ADJ
dti-1378	46	25	biomarkers	biomarker	NOUN
dti-1378	46	26	and	and	CCONJ
dti-1378	46	27	regulatory	regulatory	ADJ
dti-1378	46	28	points	point	NOUN
dti-1378	46	29	of	of	ADP
dti-1378	46	30	the	the	DET
dti-1378	46	31	parasite	parasite	NOUN
dti-1378	46	32	adenylyl	adenylyl	NOUN
dti-1378	46	33	cyclase	cyclase	NOUN
dti-1378	46	34	activity	activity	NOUN
dti-1378	46	35	.	.	PUNCT
dti-1378	47	1	the	the	DET
dti-1378	47	2	impact	impact	NOUN
dti-1378	47	3	of	of	ADP
dti-1378	47	4	conserved	conserve	VERB
dti-1378	47	5	domains	domain	NOUN
dti-1378	47	6	and	and	CCONJ
dti-1378	47	7	their	their	PRON
dti-1378	47	8	interaction	interaction	NOUN
dti-1378	47	9	was	be	AUX
dti-1378	47	10	considered	consider	VERB
dti-1378	47	11	to	to	PART
dti-1378	47	12	be	be	AUX
dti-1378	47	13	crucial	crucial	ADJ
dti-1378	47	14	for	for	ADP
dti-1378	47	15	understanding	understand	VERB
dti-1378	47	16	the	the	DET
dti-1378	47	17	biological	biological	ADJ
dti-1378	47	18	network	network	NOUN
dti-1378	47	19	of	of	ADP
dti-1378	47	20	the	the	DET
dti-1378	47	21	pathway	pathway	NOUN
dti-1378	47	22	control	control	NOUN
dti-1378	47	23	by	by	ADP
dti-1378	47	24	smp_059340.1	smp_059340.1	PROPN
dti-1378	47	25	.	.	PUNCT
dti-1378	48	1	the	the	DET
dti-1378	48	2	structural	structural	ADJ
dti-1378	48	3	bioinformatics	bioinformatics	NOUN
dti-1378	48	4	research	research	NOUN
dti-1378	48	5	on	on	ADP
dti-1378	48	6	the	the	DET
dti-1378	48	7	possible	possible	ADJ
dti-1378	48	8	characteristic	characteristic	ADJ
dti-1378	48	9	features	feature	NOUN
dti-1378	48	10	,	,	PUNCT
dti-1378	48	11	structural	structural	ADJ
dti-1378	48	12	model	model	NOUN
dti-1378	48	13	and	and	CCONJ
dti-1378	48	14	function	function	NOUN
dti-1378	48	15	of	of	ADP
dti-1378	48	16	the	the	DET
dti-1378	48	17	smp_059340.1	smp_059340.1	PROPN
dti-1378	48	18	protein	protein	NOUN
dti-1378	48	19	revealed	reveal	VERB
dti-1378	48	20	that	that	SCONJ
dti-1378	48	21	it	it	PRON
dti-1378	48	22	is	be	AUX
dti-1378	48	23	stable	stable	ADJ
dti-1378	48	24	and	and	CCONJ
dti-1378	48	25	hydrophilic	hydrophilic	ADJ
dti-1378	48	26	,	,	PUNCT
dti-1378	48	27	carrying	carry	VERB
dti-1378	48	28	a	a	DET
dti-1378	48	29	net	net	ADJ
dti-1378	48	30	positive	positive	ADJ
dti-1378	48	31	charge	charge	NOUN
dti-1378	48	32	on	on	ADP
dti-1378	48	33	its	its	PRON
dti-1378	48	34	surface	surface	NOUN
dti-1378	48	35	which	which	PRON
dti-1378	48	36	might	might	AUX
dti-1378	48	37	have	have	VERB
dti-1378	48	38	antigenic	antigenic	ADJ
dti-1378	48	39	properties	property	NOUN
dti-1378	48	40	.	.	PUNCT
dti-1378	49	1	the	the	DET
dti-1378	49	2	quality	quality	NOUN
dti-1378	49	3	of	of	ADP
dti-1378	49	4	the	the	DET
dti-1378	49	5	modeled	model	VERB
dti-1378	49	6	smp_059340.1	smp_059340.1	PROPN
dti-1378	49	7	structure	structure	NOUN
dti-1378	49	8	measured	measure	VERB
dti-1378	49	9	in	in	ADP
dti-1378	49	10	terms	term	NOUN
dti-1378	49	11	of	of	ADP
dti-1378	49	12	reliability	reliability	NOUN
dti-1378	49	13	using	use	VERB
dti-1378	49	14	the	the	DET
dti-1378	49	15	qmean	qmean	ADJ
dti-1378	49	16	score4	score4	NOUN
dti-1378	49	17	range	range	NOUN
dti-1378	49	18	was	be	AUX
dti-1378	49	19	0.68	0.68	NUM
dti-1378	49	20	,	,	PUNCT
dti-1378	49	21	and	and	CCONJ
dti-1378	49	22	the	the	DET
dti-1378	49	23	ramachandran	ramachandran	PROPN
dti-1378	49	24	plot	plot	NOUN
dti-1378	49	25	analysis	analysis	NOUN
dti-1378	49	26	indicated	indicate	VERB
dti-1378	49	27	that	that	SCONJ
dti-1378	49	28	95.72	95.72	NUM
dti-1378	49	29	%	%	NOUN
dti-1378	49	30	(	(	PUNCT
dti-1378	49	31	320	320	NUM
dti-1378	49	32	residues	residue	NOUN
dti-1378	49	33	)	)	PUNCT
dti-1378	49	34	of	of	ADP
dti-1378	49	35	the	the	DET
dti-1378	49	36	model	model	NOUN
dti-1378	49	37	residues	residue	NOUN
dti-1378	49	38	were	be	AUX
dti-1378	49	39	located	locate	VERB
dti-1378	49	40	in	in	ADP
dti-1378	49	41	the	the	DET
dti-1378	49	42	core	core	NOUN
dti-1378	49	43	or	or	CCONJ
dti-1378	49	44	favored	favor	VERB
dti-1378	49	45	region	region	NOUN
dti-1378	49	46	.	.	PUNCT
dti-1378	50	1	as	as	ADP
dti-1378	50	2	such	such	ADJ
dti-1378	50	3	,	,	PUNCT
dti-1378	50	4	the	the	DET
dti-1378	50	5	predicted	predict	VERB
dti-1378	50	6	model	model	NOUN
dti-1378	50	7	could	could	AUX
dti-1378	50	8	be	be	AUX
dti-1378	50	9	assumed	assume	VERB
dti-1378	50	10	to	to	PART
dti-1378	50	11	be	be	AUX
dti-1378	50	12	of	of	ADP
dti-1378	50	13	good	good	ADJ
dti-1378	50	14	quality	quality	NOUN
dti-1378	50	15	and	and	CCONJ
dti-1378	50	16	biologically	biologically	ADV
dti-1378	50	17	informative	informative	ADJ
dti-1378	50	18	.	.	PUNCT
dti-1378	51	1	according	accord	VERB
dti-1378	51	2	to	to	ADP
dti-1378	51	3	the	the	DET
dti-1378	51	4	reliability	reliability	NOUN
dti-1378	51	5	of	of	ADP
dti-1378	51	6	the	the	DET
dti-1378	51	7	modeled	model	VERB
dti-1378	51	8	protein	protein	NOUN
dti-1378	51	9	structure	structure	NOUN
dti-1378	51	10	,	,	PUNCT
dti-1378	51	11	the	the	DET
dti-1378	51	12	key	key	ADJ
dti-1378	51	13	residues	residue	NOUN
dti-1378	51	14	regulating	regulate	VERB
dti-1378	51	15	smp_059340.1	smp_059340.1	PROPN
dti-1378	51	16	function	function	NOUN
dti-1378	51	17	were	be	AUX
dti-1378	51	18	predicted	predict	VERB
dti-1378	51	19	to	to	PART
dti-1378	51	20	be	be	AUX
dti-1378	51	21	ser53	ser53	PROPN
dti-1378	51	22	,	,	PUNCT
dti-1378	51	23	thr188	thr188	NOUN
dti-1378	51	24	,	,	PUNCT
dti-1378	51	25	gly210	gly210	NOUN
dti-1378	51	26	and	and	CCONJ
dti-1378	51	27	asp207	asp207	NOUN
dti-1378	51	28	respectively	respectively	ADV
dti-1378	51	29	.	.	PUNCT
dti-1378	52	1	methods	method	NOUN
dti-1378	52	2	sequence	sequence	NOUN
dti-1378	52	3	retrieval	retrieval	NOUN
dti-1378	52	4	,	,	PUNCT
dti-1378	52	5	amino	amino	NOUN
dti-1378	52	6	acid	acid	NOUN
dti-1378	52	7	and	and	CCONJ
dti-1378	52	8	physicochemical	physicochemical	ADJ
dti-1378	52	9	parameters	parameter	NOUN
dti-1378	52	10	analysis	analysis	VERB
dti-1378	52	11	the	the	DET
dti-1378	52	12	s.	s.	PROPN
dti-1378	52	13	mansoni	mansoni	PROPN
dti-1378	52	14	smp_059340.1	smp_059340.1	PROPN
dti-1378	52	15	(	(	PUNCT
dti-1378	52	16	uniprot	uniprot	ADJ
dti-1378	52	17	identification	identification	NOUN
dti-1378	52	18	(	(	PUNCT
dti-1378	52	19	i	i	NOUN
dti-1378	52	20	d	d	PROPN
dti-1378	52	21	):	):	PUNCT
dti-1378	52	22	c4qdc7|c4qdc7_schma	c4qdc7|c4qdc7_schma	ADJ
dti-1378	52	23	;	;	PUNCT
dti-1378	52	24	entrez	entrez	PROPN
dti-1378	52	25	gene	gene	PROPN
dti-1378	52	26	i	i	PROPN
dti-1378	52	27	d	d	PROPN
dti-1378	52	28	:	:	PUNCT
dti-1378	52	29	smp_059340.1	smp_059340.1	PROPN
dti-1378	52	30	)	)	PUNCT
dti-1378	52	31	reviewed	review	VERB
dti-1378	52	32	sequence	sequence	NOUN
dti-1378	52	33	was	be	AUX
dti-1378	52	34	retrieved	retrieve	VERB
dti-1378	52	35	from	from	ADP
dti-1378	52	36	swiss	swiss	ADJ
dti-1378	52	37	-	-	PUNCT
dti-1378	52	38	prot	prot	NOUN
dti-1378	52	39	database	database	NOUN
dti-1378	52	40	(	(	PUNCT
dti-1378	52	41	http://expasy.org/sprot/	http://expasy.org/sprot/	PROPN
dti-1378	52	42	)	)	PUNCT
dti-1378	52	43	.	.	PUNCT
dti-1378	53	1	the	the	DET
dti-1378	53	2	amino	amino	NOUN
dti-1378	53	3	acid	acid	NOUN
dti-1378	53	4	composition	composition	NOUN
dti-1378	53	5	of	of	ADP
dti-1378	53	6	the	the	DET
dti-1378	53	7	sequence	sequence	NOUN
dti-1378	53	8	was	be	AUX
dti-1378	53	9	computed	compute	VERB
dti-1378	53	10	using	use	VERB
dti-1378	53	11	the	the	DET
dti-1378	53	12	protparam	protparam	PROPN
dti-1378	53	13	tool	tool	NOUN
dti-1378	53	14	(	(	PUNCT
dti-1378	53	15	http://www	http://www	PROPN
dti-1378	53	16	.	.	PUNCT
dti-1378	53	17	expasy.ch/cgi-bin/protparam	expasy.ch/cgi-bin/protparam	PROPN
dti-1378	53	18	)	)	PUNCT
dti-1378	53	19	.	.	PUNCT
dti-1378	54	1	the	the	DET
dti-1378	54	2	protparam	protparam	PROPN
dti-1378	54	3	tool	tool	NOUN
dti-1378	54	4	was	be	AUX
dti-1378	54	5	also	also	ADV
dti-1378	54	6	used	use	VERB
dti-1378	54	7	to	to	PART
dti-1378	54	8	compute	compute	VERB
dti-1378	54	9	the	the	DET
dti-1378	54	10	physicochemical	physicochemical	ADJ
dti-1378	54	11	parameters	parameter	NOUN
dti-1378	54	12	such	such	ADJ
dti-1378	54	13	as	as	ADP
dti-1378	54	14	theoretical	theoretical	ADJ
dti-1378	54	15	isoelectric	isoelectric	ADJ
dti-1378	54	16	point	point	NOUN
dti-1378	54	17	(	(	PUNCT
dti-1378	54	18	ip	ip	NOUN
dti-1378	54	19	)	)	PUNCT
dti-1378	54	20	,	,	PUNCT
dti-1378	54	21	molecular	molecular	ADJ
dti-1378	54	22	weight	weight	NOUN
dti-1378	54	23	,	,	PUNCT
dti-1378	54	24	total	total	ADJ
dti-1378	54	25	number	number	NOUN
dti-1378	54	26	of	of	ADP
dti-1378	54	27	positive	positive	ADJ
dti-1378	54	28	and	and	CCONJ
dti-1378	54	29	negative	negative	ADJ
dti-1378	54	30	residues	residue	NOUN
dti-1378	54	31	,	,	PUNCT
dti-1378	54	32	extinction	extinction	NOUN
dti-1378	54	33	coefficient	coefficient	NOUN
dti-1378	54	34	,	,	PUNCT
dti-1378	54	35	half	half	ADJ
dti-1378	54	36	-	-	PUNCT
dti-1378	54	37	life	life	NOUN
dti-1378	54	38	,	,	PUNCT
dti-1378	54	39	instability	instability	NOUN
dti-1378	54	40	index	index	NOUN
dti-1378	54	41	,	,	PUNCT
dti-1378	54	42	aliphatic	aliphatic	ADJ
dti-1378	54	43	index	index	NOUN
dti-1378	54	44	and	and	CCONJ
dti-1378	54	45	grand	grand	ADJ
dti-1378	54	46	average	average	NOUN
dti-1378	54	47	hydropathy	hydropathy	ADJ
dti-1378	54	48	(	(	PUNCT
dti-1378	54	49	gravy	gravy	NOUN
dti-1378	54	50	)	)	PUNCT
dti-1378	54	51	.	.	PUNCT
dti-1378	55	1	the	the	DET
dti-1378	55	2	percentages	percentage	NOUN
dti-1378	55	3	of	of	ADP
dti-1378	55	4	hydrophobic	hydrophobic	NOUN
dti-1378	55	5	and	and	CCONJ
dti-1378	55	6	hydrophilic	hydrophilic	ADJ
dti-1378	55	7	residues	residue	NOUN
dti-1378	55	8	were	be	AUX
dti-1378	55	9	calculated	calculate	VERB
dti-1378	55	10	from	from	ADP
dti-1378	55	11	the	the	DET
dti-1378	55	12	primary	primary	ADJ
dti-1378	55	13	structure	structure	NOUN
dti-1378	55	14	analysis	analysis	NOUN
dti-1378	55	15	and	and	CCONJ
dti-1378	55	16	the	the	DET
dti-1378	55	17	hydrophobicity	hydrophobicity	NOUN
dti-1378	55	18	plot	plot	NOUN
dti-1378	55	19	was	be	AUX
dti-1378	55	20	created	create	VERB
dti-1378	55	21	using	use	VERB
dti-1378	55	22	both	both	CCONJ
dti-1378	55	23	hopp	hopp	PROPN
dti-1378	55	24	-	-	PUNCT
dti-1378	55	25	woods	wood	NOUN
dti-1378	55	26	and	and	CCONJ
dti-1378	55	27	kyte	kyte	PROPN
dti-1378	55	28	-	-	PUNCT
dti-1378	55	29	doolottle	doolottle	NOUN
dti-1378	55	30	scales	scale	VERB
dti-1378	55	31	for	for	ADP
dti-1378	55	32	possible	possible	ADJ
dti-1378	55	33	antigenicity	antigenicity	NOUN
dti-1378	55	34	.	.	PUNCT
dti-1378	56	1	prediction	prediction	NOUN
dti-1378	56	2	of	of	ADP
dti-1378	56	3	secondary	secondary	ADJ
dti-1378	56	4	structure	structure	NOUN
dti-1378	56	5	elements	element	NOUN
dti-1378	56	6	and	and	CCONJ
dti-1378	56	7	conserved	conserve	VERB
dti-1378	56	8	domains	domain	NOUN
dti-1378	56	9	the	the	DET
dti-1378	56	10	sopma	sopma	NOUN
dti-1378	56	11	tool	tool	NOUN
dti-1378	56	12	(	(	PUNCT
dti-1378	56	13	http://npsa-pbil.ibcp.fr/cgi-bin/	http://npsa-pbil.ibcp.fr/cgi-bin/	NOUN
dti-1378	56	14	npsa_automat.pl?page=npsa_sopma.html	npsa_automat.pl?page=npsa_sopma.html	ADV
dti-1378	56	15	)	)	PUNCT
dti-1378	56	16	was	be	AUX
dti-1378	56	17	used	use	VERB
dti-1378	56	18	for	for	ADP
dti-1378	56	19	the	the	DET
dti-1378	56	20	secondary	secondary	ADJ
dti-1378	56	21	structure	structure	NOUN
dti-1378	56	22	prediction	prediction	NOUN
dti-1378	56	23	.	.	PUNCT
dti-1378	57	1	the	the	DET
dti-1378	57	2	tmpred	tmpred	ADJ
dti-1378	57	3	server	server	NOUN
dti-1378	57	4	(	(	PUNCT
dti-1378	57	5	ht	ht	INTJ
dti-1378	57	6	tp	tp	PROPN
dti-1378	57	7	:	:	PUNCT
dti-1378	57	8	/	/	SYM
dti-1378	57	9	/www.ch.embnet	/www.ch.embnet	PUNCT
dti-1378	57	10	.org	.org	ADJ
dti-1378	57	11	/	/	SYM
dti-1378	57	12	software/	software/	NUM
dti-1378	57	13	tmpred_form.html	tmpred_form.html	PUNCT
dti-1378	57	14	)	)	PUNCT
dti-1378	57	15	performed	perform	VERB
dti-1378	57	16	the	the	DET
dti-1378	57	17	identification	identification	NOUN
dti-1378	57	18	of	of	ADP
dti-1378	57	19	possible	possible	ADJ
dti-1378	57	20	transmembrane	transmembrane	ADJ
dti-1378	57	21	helix	helix	NOUN
dti-1378	57	22	regions	region	NOUN
dti-1378	57	23	.	.	PUNCT
dti-1378	58	1	the	the	DET
dti-1378	58	2	predicted	predict	VERB
dti-1378	58	3	transmembrane	transmembrane	ADJ
dti-1378	58	4	helices	helix	NOUN
dti-1378	58	5	region	region	NOUN
dti-1378	58	6	was	be	AUX
dti-1378	58	7	visualized	visualize	VERB
dti-1378	58	8	and	and	CCONJ
dti-1378	58	9	analyzed	analyze	VERB
dti-1378	58	10	using	use	VERB
dti-1378	58	11	helical	helical	ADJ
dti-1378	58	12	wheel	wheel	NOUN
dti-1378	58	13	plots	plot	NOUN
dti-1378	58	14	generated	generate	VERB
dti-1378	58	15	by	by	ADP
dti-1378	58	16	the	the	DET
dti-1378	58	17	program	program	NOUN
dti-1378	58	18	pepwheel	pepwheel	NOUN
dti-1378	58	19	(	(	PUNCT
dti-1378	58	20	http://emboss.bioinformatics.nl/	http://emboss.bioinformatics.nl/	PROPN
dti-1378	58	21	cgi	cgi	PROPN
dti-1378	58	22	-	-	PUNCT
dti-1378	58	23	bin	bin	NOUN
dti-1378	58	24	/	/	SYM
dti-1378	58	25	emboss	emboss	NOUN
dti-1378	58	26	/	/	SYM
dti-1378	58	27	pepwheel	pepwheel	NOUN
dti-1378	58	28	)	)	PUNCT
dti-1378	58	29	,	,	PUNCT
dti-1378	58	30	included	include	VERB
dti-1378	58	31	in	in	ADP
dti-1378	58	32	the	the	DET
dti-1378	58	33	emboss	emboss	NOUN
dti-1378	58	34	2.7	2.7	NUM
dti-1378	58	35	suite	suite	NOUN
dti-1378	58	36	.	.	PUNCT
dti-1378	59	1	the	the	DET
dti-1378	59	2	possible	possible	ADJ
dti-1378	59	3	conserved	conserved	ADJ
dti-1378	59	4	domain	domain	NOUN
dti-1378	59	5	search	search	NOUN
dti-1378	59	6	was	be	AUX
dti-1378	59	7	carried	carry	VERB
dti-1378	59	8	out	out	ADP
dti-1378	59	9	using	use	VERB
dti-1378	59	10	the	the	DET
dti-1378	59	11	public	public	ADJ
dti-1378	59	12	server	server	NOUN
dti-1378	59	13	at	at	ADP
dti-1378	59	14	http://www	http://www	PROPN
dti-1378	59	15	.	.	PUNCT
dti-1378	60	1	ncbi.nlm.nih.gov/structure/cdd/wrpsb.cgi	ncbi.nlm.nih.gov/structure/cdd/wrpsb.cgi	PROPN
dti-1378	60	2	for	for	ADP
dti-1378	60	3	the	the	DET
dti-1378	60	4	smp_059340.1	smp_059340.1	PROPN
dti-1378	60	5	,	,	PUNCT
dti-1378	60	6	and	and	CCONJ
dti-1378	60	7	the	the	DET
dti-1378	60	8	individual	individual	ADJ
dti-1378	60	9	domains	domain	NOUN
dti-1378	60	10	present	present	ADJ
dti-1378	60	11	were	be	AUX
dti-1378	60	12	analyzed	analyze	VERB
dti-1378	60	13	and	and	CCONJ
dti-1378	60	14	binding	bind	VERB
dti-1378	60	15	residues	residue	NOUN
dti-1378	60	16	were	be	AUX
dti-1378	60	17	compared	compare	VERB
dti-1378	60	18	within	within	ADP
dti-1378	60	19	the	the	DET
dti-1378	60	20	domains	domain	NOUN
dti-1378	60	21	.	.	PUNCT
dti-1378	60	22	http://www.la-press.com	http://www.la-press.com	X
dti-1378	61	1	http://expasy.org/sprot/	http://expasy.org/sprot/	VERB
dti-1378	61	2	http://www.expasy.ch/cgi-bin/protparam	http://www.expasy.ch/cgi-bin/protparam	PROPN
dti-1378	61	3	http://npsa-pbil.ibcp.fr/cgi-bin/npsa_automat.pl?page=npsa_sopma.html	http://npsa-pbil.ibcp.fr/cgi-bin/npsa_automat.pl?page=npsa_sopma.html	VERB
dti-1378	61	4	http://www.ch.embnet.org/software/tmpred_form.html	http://www.ch.embnet.org/software/tmpred_form.html	PROPN
dti-1378	62	1	http://emboss.bioinformatics.nl/cgi-bin/emboss/pepwheel	http://emboss.bioinformatics.nl/cgi-bin/emboss/pepwheel	PROPN
dti-1378	62	2	http://www.ncbi.nlm.nih.gov/structure/cdd/wrpsb.cgi	http://www.ncbi.nlm.nih.gov/structure/cdd/wrpsb.cgi	PROPN
dti-1378	62	3	mbah	mbah	PROPN
dti-1378	62	4	et	et	PROPN
dti-1378	62	5	al	al	PROPN
dti-1378	62	6	44	44	NUM
dti-1378	62	7	drug	drug	NOUN
dti-1378	62	8	target	target	NOUN
dti-1378	62	9	insights	insight	NOUN
dti-1378	62	10	2012:6	2012:6	ADJ
dti-1378	62	11	homology	homology	NOUN
dti-1378	62	12	modeling	modeling	NOUN
dti-1378	62	13	and	and	CCONJ
dti-1378	62	14	visualization	visualization	NOUN
dti-1378	62	15	of	of	ADP
dti-1378	62	16	3d	3d	PROPN
dti-1378	62	17	structure	structure	NOUN
dti-1378	62	18	the	the	DET
dti-1378	62	19	three	three	NUM
dti-1378	62	20	-	-	PUNCT
dti-1378	62	21	dimensional	dimensional	ADJ
dti-1378	62	22	(	(	PUNCT
dti-1378	62	23	3d	3d	NOUN
dti-1378	62	24	)	)	PUNCT
dti-1378	62	25	structure	structure	NOUN
dti-1378	62	26	of	of	ADP
dti-1378	62	27	the	the	DET
dti-1378	62	28	smp_059340.1	smp_059340.1	PROPN
dti-1378	62	29	encoded	encode	VERB
dti-1378	62	30	protein	protein	NOUN
dti-1378	62	31	was	be	AUX
dti-1378	62	32	modeled	model	VERB
dti-1378	62	33	using	use	VERB
dti-1378	62	34	the	the	DET
dti-1378	62	35	pdb	pdb	NOUN
dti-1378	62	36	template	template	NOUN
dti-1378	62	37	1tl7c	1tl7c	NUM
dti-1378	62	38	(	(	PUNCT
dti-1378	62	39	chain	chain	NOUN
dti-1378	62	40	c	c	NOUN
dti-1378	62	41	)	)	PUNCT
dti-1378	62	42	.	.	PUNCT
dti-1378	63	1	the	the	DET
dti-1378	63	2	3d	3d	PROPN
dti-1378	63	3	structure	structure	NOUN
dti-1378	63	4	of	of	ADP
dti-1378	63	5	the	the	DET
dti-1378	63	6	smp_059340.1	smp_059340.1	PROPN
dti-1378	63	7	protein	protein	NOUN
dti-1378	63	8	was	be	AUX
dti-1378	63	9	generated	generate	VERB
dti-1378	63	10	using	use	VERB
dti-1378	63	11	the	the	DET
dti-1378	63	12	swissmodel	swissmodel	PROPN
dti-1378	63	13	server	server	NOUN
dti-1378	63	14	(	(	PUNCT
dti-1378	63	15	http://	http://	PROPN
dti-1378	63	16	swissmodel.expasy	swissmodel.expasy	PROPN
dti-1378	63	17	.	.	PROPN
dti-1378	63	18	org/	org/	PROPN
dti-1378	63	19	)	)	PUNCT
dti-1378	63	20	and	and	CCONJ
dti-1378	63	21	the	the	DET
dti-1378	63	22	phyre	phyre	PROPN
dti-1378	63	23	/	/	SYM
dti-1378	63	24	phyre2	phyre2	PROPN
dti-1378	63	25	server	server	NOUN
dti-1378	63	26	(	(	PUNCT
dti-1378	63	27	http://www.sbg	http://www.sbg	PROPN
dti-1378	63	28	.	.	PUNCT
dti-1378	64	1	bio.ic.ac.uk/phyre2/html/page.cgi?id=news	bio.ic.ac.uk/phyre2/html/page.cgi?id=new	NOUN
dti-1378	64	2	)	)	PUNCT
dti-1378	64	3	.	.	PUNCT
dti-1378	65	1	the	the	DET
dti-1378	65	2	quality	quality	NOUN
dti-1378	65	3	of	of	ADP
dti-1378	65	4	the	the	DET
dti-1378	65	5	model	model	NOUN
dti-1378	65	6	was	be	AUX
dti-1378	65	7	evaluated	evaluate	VERB
dti-1378	65	8	with	with	ADP
dti-1378	65	9	ramachandran	ramachandran	PROPN
dti-1378	65	10	plot	plot	PROPN
dti-1378	65	11	data	data	PROPN
dti-1378	65	12	,	,	PUNCT
dti-1378	65	13	based	base	VERB
dti-1378	65	14	on	on	ADP
dti-1378	65	15	the	the	DET
dti-1378	65	16	phi	phi	NOUN
dti-1378	65	17	–	–	PUNCT
dti-1378	65	18	psi	psi	NOUN
dti-1378	65	19	torsion	torsion	NOUN
dti-1378	65	20	angles	angle	NOUN
dti-1378	65	21	of	of	ADP
dti-1378	65	22	all	all	DET
dti-1378	65	23	the	the	DET
dti-1378	65	24	residues	residue	NOUN
dti-1378	65	25	in	in	ADP
dti-1378	65	26	the	the	DET
dti-1378	65	27	model	model	NOUN
dti-1378	65	28	using	use	VERB
dti-1378	65	29	ramachandran	ramachandran	PROPN
dti-1378	65	30	plot2	plot2	PROPN
dti-1378	65	31	assessment	assessment	PROPN
dti-1378	65	32	server	server	PROPN
dti-1378	65	33	(	(	PUNCT
dti-1378	65	34	http://dicsoft1.physics.iisc.ernet.in/rp/	http://dicsoft1.physics.iisc.ernet.in/rp/	NOUN
dti-1378	65	35	)	)	PUNCT
dti-1378	65	36	and	and	CCONJ
dti-1378	65	37	rampage	rampage	NOUN
dti-1378	65	38	server	server	NOUN
dti-1378	65	39	(	(	PUNCT
dti-1378	65	40	http://mordred.bioc.cam.ac.uk/∼rapper/rampage	http://mordred.bioc.cam.ac.uk/∼rapper/rampage	NOUN
dti-1378	65	41	.	.	PUNCT
dti-1378	65	42	php	php	PROPN
dti-1378	65	43	)	)	PUNCT
dti-1378	65	44	.	.	PUNCT
dti-1378	66	1	the	the	DET
dti-1378	66	2	rasmol	rasmol	PROPN
dti-1378	66	3	tool	tool	NOUN
dti-1378	66	4	(	(	PUNCT
dti-1378	66	5	http://www.openrasmol.org/	http://www.openrasmol.org/	X
dti-1378	66	6	)	)	PUNCT
dti-1378	66	7	was	be	AUX
dti-1378	66	8	used	use	VERB
dti-1378	66	9	to	to	PART
dti-1378	66	10	visualize	visualize	VERB
dti-1378	66	11	the	the	DET
dti-1378	66	12	modeled	model	VERB
dti-1378	66	13	3d	3d	NOUN
dti-1378	66	14	structures	structure	NOUN
dti-1378	66	15	and	and	CCONJ
dti-1378	66	16	to	to	PART
dti-1378	66	17	identify	identify	VERB
dti-1378	66	18	any	any	DET
dti-1378	66	19	possible	possible	ADJ
dti-1378	66	20	“	"	PUNCT
dti-1378	66	21	ss	ss	NOUN
dti-1378	66	22	”	"	PUNCT
dti-1378	66	23	bonds	bond	NOUN
dti-1378	66	24	including	include	VERB
dti-1378	66	25	the	the	DET
dti-1378	66	26	distribution	distribution	NOUN
dti-1378	66	27	of	of	ADP
dti-1378	66	28	the	the	DET
dti-1378	66	29	secondary	secondary	ADJ
dti-1378	66	30	structures	structure	NOUN
dti-1378	66	31	.	.	PUNCT
dti-1378	67	1	the	the	DET
dti-1378	67	2	three	three	NUM
dti-1378	67	3	-	-	PUNCT
dti-1378	67	4	dimensional	dimensional	ADJ
dti-1378	67	5	(	(	PUNCT
dti-1378	67	6	3d	3d	NOUN
dti-1378	67	7	)	)	PUNCT
dti-1378	67	8	ligandsite	ligandsite	NOUN
dti-1378	67	9	residue(s	residue(s	PROPN
dti-1378	67	10	)	)	PUNCT
dti-1378	67	11	and	and	CCONJ
dti-1378	67	12	the	the	DET
dti-1378	67	13	predicted	predict	VERB
dti-1378	67	14	ligand(s	ligand(s	PROPN
dti-1378	67	15	)	)	PUNCT
dti-1378	67	16	of	of	ADP
dti-1378	67	17	the	the	DET
dti-1378	67	18	smp_059340.1	smp_059340.1	PROPN
dti-1378	67	19	protein	protein	NOUN
dti-1378	67	20	were	be	AUX
dti-1378	67	21	determined	determine	VERB
dti-1378	67	22	using	use	VERB
dti-1378	67	23	3dligandsite	3dligandsite	NUM
dti-1378	67	24	server	server	NOUN
dti-1378	67	25	at	at	ADP
dti-1378	67	26	(	(	PUNCT
dti-1378	67	27	http://www.sbg.bio.ic.ac.uk/3dligandsite	http://www.sbg.bio.ic.ac.uk/3dligandsite	PROPN
dti-1378	67	28	)	)	PUNCT
dti-1378	67	29	.	.	PUNCT
dti-1378	68	1	the	the	DET
dti-1378	68	2	rasmol	rasmol	PROPN
dti-1378	68	3	tool	tool	NOUN
dti-1378	68	4	was	be	AUX
dti-1378	68	5	further	far	ADV
dti-1378	68	6	used	use	VERB
dti-1378	68	7	in	in	ADP
dti-1378	68	8	locating	locate	VERB
dti-1378	68	9	the	the	DET
dti-1378	68	10	positions	position	NOUN
dti-1378	68	11	of	of	ADP
dti-1378	68	12	the	the	DET
dti-1378	68	13	conserved	conserve	VERB
dti-1378	68	14	domains	domain	NOUN
dti-1378	68	15	and	and	CCONJ
dti-1378	68	16	the	the	DET
dti-1378	68	17	keys	key	NOUN
dti-1378	68	18	residues	residue	NOUN
dti-1378	68	19	involved	involve	VERB
dti-1378	68	20	in	in	ADP
dti-1378	68	21	regulatory	regulatory	ADJ
dti-1378	68	22	mechanism	mechanism	NOUN
dti-1378	68	23	on	on	ADP
dti-1378	68	24	the	the	DET
dti-1378	68	25	3d	3d	NOUN
dti-1378	68	26	and	and	CCONJ
dti-1378	68	27	folded	fold	VERB
dti-1378	68	28	structure	structure	NOUN
dti-1378	68	29	.	.	PUNCT
dti-1378	69	1	particularly	particularly	ADV
dti-1378	69	2	the	the	DET
dti-1378	69	3	key	key	ADJ
dti-1378	69	4	residues	residue	NOUN
dti-1378	69	5	involved	involve	VERB
dti-1378	69	6	in	in	ADP
dti-1378	69	7	its	its	PRON
dti-1378	69	8	regulatory	regulatory	ADJ
dti-1378	69	9	mechanism	mechanism	NOUN
dti-1378	69	10	.	.	PUNCT
dti-1378	70	1	with	with	ADP
dti-1378	70	2	the	the	DET
dti-1378	70	3	rasmol	rasmol	PROPN
dti-1378	70	4	tool	tool	NOUN
dti-1378	70	5	,	,	PUNCT
dti-1378	70	6	the	the	DET
dti-1378	70	7	actual	actual	ADJ
dti-1378	70	8	locations	location	NOUN
dti-1378	70	9	of	of	ADP
dti-1378	70	10	all	all	DET
dti-1378	70	11	domains	domain	NOUN
dti-1378	70	12	were	be	AUX
dti-1378	70	13	mapped	map	VERB
dti-1378	70	14	on	on	ADP
dti-1378	70	15	the	the	DET
dti-1378	70	16	protein	protein	NOUN
dti-1378	70	17	3d	3d	NOUN
dti-1378	70	18	structure	structure	NOUN
dti-1378	70	19	and	and	CCONJ
dti-1378	70	20	folded	fold	VERB
dti-1378	70	21	structure	structure	NOUN
dti-1378	70	22	.	.	PUNCT
dti-1378	71	1	results	result	VERB
dti-1378	71	2	amino	amino	NOUN
dti-1378	71	3	acid	acid	NOUN
dti-1378	71	4	content	content	NOUN
dti-1378	71	5	and	and	CCONJ
dti-1378	71	6	physicochemical	physicochemical	ADJ
dti-1378	71	7	parameters	parameter	NOUN
dti-1378	71	8	the	the	DET
dti-1378	71	9	analysis	analysis	NOUN
dti-1378	71	10	of	of	ADP
dti-1378	71	11	amino	amino	NOUN
dti-1378	71	12	acid	acid	NOUN
dti-1378	71	13	content	content	NOUN
dti-1378	71	14	and	and	CCONJ
dti-1378	71	15	physicochemical	physicochemical	ADJ
dti-1378	71	16	parameters	parameter	NOUN
dti-1378	71	17	suggests	suggest	VERB
dti-1378	71	18	that	that	SCONJ
dti-1378	71	19	smp_059340.1	smp_059340.1	PROPN
dti-1378	71	20	is	be	AUX
dti-1378	71	21	moderately	moderately	ADV
dti-1378	71	22	hydrophilic	hydrophilic	ADJ
dti-1378	71	23	,	,	PUNCT
dti-1378	71	24	due	due	ADP
dti-1378	71	25	to	to	ADP
dti-1378	71	26	the	the	DET
dti-1378	71	27	presence	presence	NOUN
dti-1378	71	28	of	of	ADP
dti-1378	71	29	high	high	ADJ
dti-1378	71	30	polar	polar	ADJ
dti-1378	71	31	amino	amino	NOUN
dti-1378	71	32	acid	acid	NOUN
dti-1378	71	33	residues	residue	NOUN
dti-1378	71	34	(	(	PUNCT
dti-1378	71	35	50.7	50.7	NUM
dti-1378	71	36	%	%	NOUN
dti-1378	71	37	)	)	PUNCT
dti-1378	71	38	against	against	ADP
dti-1378	71	39	non	non	ADJ
dti-1378	71	40	-	-	ADJ
dti-1378	71	41	polar	polar	ADJ
dti-1378	71	42	(	(	PUNCT
dti-1378	71	43	hydrophobic	hydrophobic	NOUN
dti-1378	71	44	)	)	PUNCT
dti-1378	71	45	amino	amino	ADJ
dti-1378	71	46	acids	acid	NOUN
dti-1378	71	47	residues	residue	NOUN
dti-1378	71	48	(	(	PUNCT
dti-1378	71	49	34.95	34.95	NUM
dti-1378	71	50	%	%	NOUN
dti-1378	71	51	)	)	PUNCT
dti-1378	71	52	in	in	ADP
dti-1378	71	53	the	the	DET
dti-1378	71	54	sequence	sequence	NOUN
dti-1378	71	55	(	(	PUNCT
dti-1378	71	56	table	table	NOUN
dti-1378	71	57	1	1	NUM
dti-1378	71	58	)	)	PUNCT
dti-1378	71	59	.	.	PUNCT
dti-1378	72	1	the	the	DET
dti-1378	72	2	protein	protein	NOUN
dti-1378	72	3	is	be	AUX
dti-1378	72	4	made	make	VERB
dti-1378	72	5	up	up	ADP
dti-1378	72	6	of	of	ADP
dti-1378	72	7	379	379	NUM
dti-1378	72	8	amino	amino	NOUN
dti-1378	72	9	acid	acid	NOUN
dti-1378	72	10	residues	residue	NOUN
dti-1378	72	11	,	,	PUNCT
dti-1378	72	12	with	with	ADP
dti-1378	72	13	20	20	NUM
dti-1378	72	14	amino	amino	ADJ
dti-1378	72	15	acids	acid	NOUN
dti-1378	72	16	present	present	NOUN
dti-1378	72	17	in	in	ADP
dti-1378	72	18	the	the	DET
dti-1378	72	19	primary	primary	ADJ
dti-1378	72	20	structure	structure	NOUN
dti-1378	72	21	,	,	PUNCT
dti-1378	72	22	constituting	constitute	VERB
dti-1378	72	23	an	an	DET
dti-1378	72	24	average	average	ADJ
dti-1378	72	25	molecular	molecular	ADJ
dti-1378	72	26	weight	weight	NOUN
dti-1378	72	27	of	of	ADP
dti-1378	72	28	44045.5	44045.5	NUM
dti-1378	72	29	da	da	NOUN
dti-1378	72	30	.	.	PUNCT
dti-1378	73	1	the	the	DET
dti-1378	73	2	present	present	ADJ
dti-1378	73	3	analysis	analysis	NOUN
dti-1378	73	4	indicates	indicate	VERB
dti-1378	73	5	that	that	SCONJ
dti-1378	73	6	there	there	PRON
dti-1378	73	7	are	be	VERB
dti-1378	73	8	a	a	DET
dti-1378	73	9	large	large	ADJ
dti-1378	73	10	proportion	proportion	NOUN
dti-1378	73	11	of	of	ADP
dti-1378	73	12	leucine	leucine	NOUN
dti-1378	73	13	(	(	PUNCT
dti-1378	73	14	leu	leu	PROPN
dti-1378	73	15	)	)	PUNCT
dti-1378	73	16	,	,	PUNCT
dti-1378	73	17	glutamate	glutamate	NOUN
dti-1378	73	18	(	(	PUNCT
dti-1378	73	19	glu	glu	NOUN
dti-1378	73	20	)	)	PUNCT
dti-1378	73	21	,	,	PUNCT
dti-1378	73	22	lysine	lysine	NOUN
dti-1378	73	23	(	(	PUNCT
dti-1378	73	24	lys	lys	PROPN
dti-1378	73	25	)	)	PUNCT
dti-1378	73	26	,	,	PUNCT
dti-1378	73	27	arganine	arganine	PROPN
dti-1378	73	28	(	(	PUNCT
dti-1378	73	29	arg	arg	NOUN
dti-1378	73	30	)	)	PUNCT
dti-1378	73	31	,	,	PUNCT
dti-1378	73	32	isoleucine	isoleucine	NOUN
dti-1378	73	33	(	(	PUNCT
dti-1378	73	34	ile	ile	PROPN
dti-1378	73	35	)	)	PUNCT
dti-1378	73	36	and	and	CCONJ
dti-1378	73	37	serine	serine	NOUN
dti-1378	73	38	(	(	PUNCT
dti-1378	73	39	ser	ser	NOUN
dti-1378	73	40	)	)	PUNCT
dti-1378	73	41	in	in	ADP
dti-1378	73	42	that	that	DET
dti-1378	73	43	order	order	NOUN
dti-1378	73	44	(	(	PUNCT
dti-1378	73	45	table	table	NOUN
dti-1378	73	46	1	1	NUM
dti-1378	73	47	)	)	PUNCT
dti-1378	73	48	.	.	PUNCT
dti-1378	74	1	the	the	DET
dti-1378	74	2	atomic	atomic	ADJ
dti-1378	74	3	composition	composition	NOUN
dti-1378	74	4	(	(	PUNCT
dti-1378	74	5	6191	6191	NUM
dti-1378	74	6	)	)	PUNCT
dti-1378	74	7	consists	consist	VERB
dti-1378	74	8	of	of	ADP
dti-1378	74	9	1961	1961	NUM
dti-1378	74	10	carbons	carbon	NOUN
dti-1378	74	11	(	(	PUNCT
dti-1378	74	12	c	c	NOUN
dti-1378	74	13	)	)	PUNCT
dti-1378	74	14	,	,	PUNCT
dti-1378	74	15	3093	3093	NUM
dti-1378	74	16	hydrogen	hydrogen	NOUN
dti-1378	74	17	(	(	PUNCT
dti-1378	74	18	h	h	NOUN
dti-1378	74	19	)	)	PUNCT
dti-1378	74	20	,	,	PUNCT
dti-1378	74	21	547	547	NUM
dti-1378	74	22	nitrogen	nitrogen	NOUN
dti-1378	74	23	(	(	PUNCT
dti-1378	74	24	n	n	CCONJ
dti-1378	74	25	)	)	PUNCT
dti-1378	74	26	,	,	PUNCT
dti-1378	74	27	573	573	NUM
dti-1378	74	28	oxygen	oxygen	NOUN
dti-1378	74	29	(	(	PUNCT
dti-1378	74	30	o	o	NOUN
dti-1378	74	31	)	)	PUNCT
dti-1378	74	32	and	and	CCONJ
dti-1378	74	33	17	17	NUM
dti-1378	74	34	sulfur	sulfur	NOUN
dti-1378	74	35	atoms	atom	NOUN
dti-1378	74	36	,	,	PUNCT
dti-1378	74	37	with	with	ADP
dti-1378	74	38	a	a	DET
dti-1378	74	39	molecular	molecular	ADJ
dti-1378	74	40	formula	formula	NOUN
dti-1378	74	41	of	of	ADP
dti-1378	74	42	c1961h3093	c1961h3093	ADJ
dti-1378	74	43	n547o573s17	n547o573s17	PROPN
dti-1378	74	44	(	(	PUNCT
dti-1378	74	45	table	table	NOUN
dti-1378	74	46	2	2	NUM
dti-1378	74	47	)	)	PUNCT
dti-1378	74	48	.	.	PUNCT
dti-1378	75	1	the	the	DET
dti-1378	75	2	17	17	NUM
dti-1378	75	3	sulfur	sulfur	NOUN
dti-1378	75	4	atoms	atom	NOUN
dti-1378	75	5	were	be	AUX
dti-1378	75	6	made	make	VERB
dti-1378	75	7	up	up	ADP
dti-1378	75	8	of	of	ADP
dti-1378	75	9	11	11	NUM
dti-1378	75	10	cysteine	cysteine	NOUN
dti-1378	75	11	(	(	PUNCT
dti-1378	75	12	cys	cys	PROPN
dti-1378	75	13	)	)	PUNCT
dti-1378	75	14	and	and	CCONJ
dti-1378	75	15	6	6	NUM
dti-1378	75	16	methionine	methionine	NOUN
dti-1378	75	17	(	(	PUNCT
dti-1378	75	18	met	meet	VERB
dti-1378	75	19	)	)	PUNCT
dti-1378	75	20	residues	residue	NOUN
dti-1378	75	21	present	present	ADJ
dti-1378	75	22	in	in	ADP
dti-1378	75	23	the	the	DET
dti-1378	75	24	primary	primary	ADJ
dti-1378	75	25	structure	structure	NOUN
dti-1378	75	26	.	.	PUNCT
dti-1378	76	1	the	the	DET
dti-1378	76	2	computed	compute	VERB
dti-1378	76	3	isoelectric	isoelectric	ADJ
dti-1378	76	4	point	point	NOUN
dti-1378	76	5	(	(	PUNCT
dti-1378	76	6	pi	pi	NOUN
dti-1378	76	7	)	)	PUNCT
dti-1378	76	8	was	be	AUX
dti-1378	76	9	8.51	8.51	NUM
dti-1378	76	10	(	(	PUNCT
dti-1378	76	11	pi	pi	NOUN
dti-1378	76	12	.	.	PUNCT
dti-1378	77	1	7	7	X
dti-1378	77	2	)	)	PUNCT
dti-1378	77	3	,	,	PUNCT
dti-1378	77	4	indicating	indicate	VERB
dti-1378	77	5	that	that	SCONJ
dti-1378	77	6	this	this	DET
dti-1378	77	7	protein	protein	NOUN
dti-1378	77	8	is	be	AUX
dti-1378	77	9	basic	basic	ADJ
dti-1378	77	10	in	in	ADP
dti-1378	77	11	nature	nature	NOUN
dti-1378	77	12	.	.	PUNCT
dti-1378	78	1	the	the	DET
dti-1378	78	2	protparam	protparam	PROPN
dti-1378	78	3	extinction	extinction	NOUN
dti-1378	78	4	coefficient	coefficient	NOUN
dti-1378	78	5	,	,	PUNCT
dti-1378	78	6	at	at	ADP
dti-1378	78	7	a	a	DET
dti-1378	78	8	wavelength	wavelength	NOUN
dti-1378	78	9	of	of	ADP
dti-1378	78	10	280	280	NUM
dti-1378	78	11	nm	nm	NOUN
dti-1378	78	12	measured	measure	VERB
dti-1378	78	13	in	in	ADP
dti-1378	78	14	water	water	NOUN
dti-1378	78	15	,	,	PUNCT
dti-1378	78	16	is	be	AUX
dti-1378	78	17	favorable	favorable	ADJ
dti-1378	78	18	because	because	SCONJ
dti-1378	78	19	proteins	protein	NOUN
dti-1378	78	20	have	have	VERB
dti-1378	78	21	stronger	strong	ADJ
dti-1378	78	22	absorption	absorption	NOUN
dti-1378	78	23	capabilities	capability	NOUN
dti-1378	78	24	at	at	ADP
dti-1378	78	25	this	this	DET
dti-1378	78	26	wavelength	wavelength	NOUN
dti-1378	78	27	than	than	ADP
dti-1378	78	28	other	other	ADJ
dti-1378	78	29	substances	substance	NOUN
dti-1378	78	30	commonly	commonly	ADV
dti-1378	78	31	found	find	VERB
dti-1378	78	32	in	in	ADP
dti-1378	78	33	the	the	DET
dti-1378	78	34	solution	solution	NOUN
dti-1378	78	35	.	.	PUNCT
dti-1378	79	1	the	the	DET
dti-1378	79	2	extinction	extinction	NOUN
dti-1378	79	3	coefficient	coefficient	NOUN
dti-1378	79	4	for	for	ADP
dti-1378	79	5	this	this	DET
dti-1378	79	6	protein	protein	NOUN
dti-1378	79	7	was	be	AUX
dti-1378	79	8	computed	compute	VERB
dti-1378	79	9	with	with	ADP
dti-1378	79	10	respect	respect	NOUN
dti-1378	79	11	to	to	ADP
dti-1378	79	12	cys	cys	NOUN
dti-1378	79	13	,	,	PUNCT
dti-1378	79	14	tryptophan	tryptophan	NOUN
dti-1378	79	15	(	(	PUNCT
dti-1378	79	16	trp	trp	NOUN
dti-1378	79	17	)	)	PUNCT
dti-1378	79	18	and	and	CCONJ
dti-1378	79	19	tyrosine	tyrosine	NOUN
dti-1378	79	20	(	(	PUNCT
dti-1378	79	21	tyr	tyr	PROPN
dti-1378	79	22	)	)	PUNCT
dti-1378	79	23	as	as	SCONJ
dti-1378	79	24	they	they	PRON
dti-1378	79	25	were	be	AUX
dti-1378	79	26	present	present	ADJ
dti-1378	79	27	in	in	ADP
dti-1378	79	28	the	the	DET
dti-1378	79	29	primary	primary	ADJ
dti-1378	79	30	structure	structure	NOUN
dti-1378	79	31	.	.	PUNCT
dti-1378	80	1	the	the	DET
dti-1378	80	2	estimated	estimate	VERB
dti-1378	80	3	half	half	ADJ
dti-1378	80	4	-	-	PUNCT
dti-1378	80	5	life	life	NOUN
dti-1378	80	6	of	of	ADP
dti-1378	80	7	this	this	DET
dti-1378	80	8	protein	protein	NOUN
dti-1378	80	9	with	with	ADP
dti-1378	80	10	met	meet	VERB
dti-1378	80	11	as	as	ADP
dti-1378	80	12	the	the	DET
dti-1378	80	13	n	n	NOUN
dti-1378	80	14	-	-	PUNCT
dti-1378	80	15	terminal	terminal	NOUN
dti-1378	80	16	of	of	ADP
dti-1378	80	17	the	the	DET
dti-1378	80	18	sequence	sequence	NOUN
dti-1378	80	19	was	be	AUX
dti-1378	80	20	30	30	NUM
dti-1378	80	21	(	(	PUNCT
dti-1378	80	22	.20	.20	NUM
dti-1378	80	23	)	)	PUNCT
dti-1378	80	24	hours	hour	NOUN
dti-1378	80	25	.	.	PUNCT
dti-1378	81	1	the	the	DET
dti-1378	81	2	predicted	predict	VERB
dti-1378	81	3	instability	instability	NOUN
dti-1378	81	4	index	index	NOUN
dti-1378	81	5	was	be	AUX
dti-1378	81	6	48.15	48.15	NUM
dti-1378	81	7	and	and	CCONJ
dti-1378	81	8	82.17	82.17	NUM
dti-1378	81	9	for	for	ADP
dti-1378	81	10	aliphatic	aliphatic	ADJ
dti-1378	81	11	index	index	NOUN
dti-1378	81	12	,	,	PUNCT
dti-1378	81	13	with	with	ADP
dti-1378	81	14	a	a	DET
dti-1378	81	15	very	very	ADV
dti-1378	81	16	low	low	ADJ
dti-1378	81	17	gravy	gravy	NOUN
dti-1378	81	18	index	index	NOUN
dti-1378	81	19	of	of	ADP
dti-1378	81	20	−0.458	−0.458	PROPN
dti-1378	81	21	.	.	PUNCT
dti-1378	82	1	the	the	DET
dti-1378	82	2	hopp	hopp	PROPN
dti-1378	82	3	-	-	PUNCT
dti-1378	82	4	woods	woods	PROPN
dti-1378	82	5	scale	scale	NOUN
dti-1378	82	6	identified	identify	VERB
dti-1378	82	7	three	three	NUM
dti-1378	82	8	regions	region	NOUN
dti-1378	82	9	on	on	ADP
dti-1378	82	10	this	this	DET
dti-1378	82	11	polypeptide	polypeptide	NOUN
dti-1378	82	12	predicted	predict	VERB
dti-1378	82	13	to	to	PART
dti-1378	82	14	be	be	AUX
dti-1378	82	15	highly	highly	ADV
dti-1378	82	16	hydrophilic	hydrophilic	ADJ
dti-1378	82	17	.	.	PUNCT
dti-1378	83	1	the	the	DET
dti-1378	83	2	hydrophilic	hydrophilic	ADJ
dti-1378	83	3	regions	region	NOUN
dti-1378	83	4	are	be	AUX
dti-1378	83	5	table	table	NOUN
dti-1378	83	6	1	1	NUM
dti-1378	83	7	.	.	PUNCT
dti-1378	83	8	amino	amino	NOUN
dti-1378	83	9	acid	acid	NOUN
dti-1378	83	10	composition	composition	NOUN
dti-1378	83	11	of	of	ADP
dti-1378	83	12	smp_059340.1	smp_059340.1	PROPN
dti-1378	83	13	computed	compute	VERB
dti-1378	83	14	using	use	VERB
dti-1378	83	15	protparam	protparam	PROPN
dti-1378	83	16	server	server	NOUN
dti-1378	83	17	.	.	PUNCT
dti-1378	83	18	amino	amino	NOUN
dti-1378	83	19	acid	acid	NOUN
dti-1378	83	20	composition	composition	NOUN
dti-1378	83	21	(	(	PUNCT
dti-1378	83	22	%	%	INTJ
dti-1378	83	23	)	)	PUNCT
dti-1378	83	24	hydrophilic	hydrophilic	NOUN
dti-1378	83	25	(	(	PUNCT
dti-1378	83	26	%	%	INTJ
dti-1378	83	27	)	)	PUNCT
dti-1378	83	28	hydrophobic	hydrophobic	NOUN
dti-1378	83	29	(	(	PUNCT
dti-1378	83	30	%	%	INTJ
dti-1378	83	31	)	)	PUNCT
dti-1378	83	32	ala	ala	PROPN
dti-1378	83	33	6.1	6.1	NUM
dti-1378	83	34	6.1	6.1	NUM
dti-1378	83	35	arg	arg	NOUN
dti-1378	83	36	7.4	7.4	NUM
dti-1378	83	37	7.4	7.4	NUM
dti-1378	83	38	asn	asn	NOUN
dti-1378	83	39	5.8	5.8	NUM
dti-1378	83	40	5.8	5.8	NUM
dti-1378	83	41	asp	asp	NOUN
dti-1378	83	42	5.8	5.8	NUM
dti-1378	83	43	5.8	5.8	NUM
dti-1378	83	44	cys	cys	PROPN
dti-1378	83	45	2.9	2.9	NUM
dti-1378	83	46	gln	gln	PROPN
dti-1378	83	47	3.2	3.2	NUM
dti-1378	83	48	3.2	3.2	NUM
dti-1378	83	49	glu	glu	NOUN
dti-1378	83	50	8.2	8.2	NUM
dti-1378	83	51	8.2	8.2	NUM
dti-1378	83	52	gly	gly	NOUN
dti-1378	83	53	4.2	4.2	NUM
dti-1378	83	54	4.2	4.2	NUM
dti-1378	83	55	his	his	PRON
dti-1378	83	56	2.1	2.1	NUM
dti-1378	83	57	2.1	2.1	NUM
dti-1378	83	58	ile	ile	PROPN
dti-1378	83	59	7.2	7.2	NUM
dti-1378	83	60	7.2	7.2	NUM
dti-1378	83	61	leu	leu	PROPN
dti-1378	83	62	9.2	9.2	NUM
dti-1378	83	63	9.2	9.2	NUM
dti-1378	83	64	lys	lys	PROPN
dti-1378	83	65	7.9	7.9	NUM
dti-1378	83	66	7.9	7.9	NUM
dti-1378	83	67	met	meet	VERB
dti-1378	83	68	1.6	1.6	NUM
dti-1378	83	69	phe	phe	NOUN
dti-1378	83	70	5.3	5.3	NUM
dti-1378	83	71	pro	pro	ADJ
dti-1378	83	72	2.9	2.9	NUM
dti-1378	83	73	2.9	2.9	NUM
dti-1378	83	74	ser	ser	NOUN
dti-1378	83	75	6.1	6.1	NUM
dti-1378	83	76	6.1	6.1	NUM
dti-1378	83	77	thr	thr	PROPN
dti-1378	83	78	4.2	4.2	NUM
dti-1378	83	79	4.2	4.2	NUM
dti-1378	83	80	trp	trp	PROPN
dti-1378	83	81	1.1	1.1	NUM
dti-1378	83	82	tyr	tyr	NOUN
dti-1378	83	83	3.7	3.7	NUM
dti-1378	83	84	val	val	NOUN
dti-1378	83	85	5.3	5.3	NUM
dti-1378	83	86	5.3	5.3	NUM
dti-1378	83	87	total	total	NOUN
dti-1378	83	88	100.0	100.0	NUM
dti-1378	83	89	50.7	50.7	NUM
dti-1378	83	90	34.9	34.9	NUM
dti-1378	83	91	notes	note	NOUN
dti-1378	83	92	:	:	PUNCT
dti-1378	83	93	the	the	DET
dti-1378	83	94	composition	composition	NOUN
dti-1378	83	95	of	of	ADP
dti-1378	83	96	each	each	DET
dti-1378	83	97	amino	amino	NOUN
dti-1378	83	98	acid	acid	NOUN
dti-1378	83	99	residue	residue	NOUN
dti-1378	83	100	is	be	AUX
dti-1378	83	101	indicated	indicate	VERB
dti-1378	83	102	as	as	ADP
dti-1378	83	103	a	a	DET
dti-1378	83	104	percentage	percentage	NOUN
dti-1378	83	105	.	.	PUNCT
dti-1378	84	1	the	the	DET
dti-1378	84	2	composition	composition	NOUN
dti-1378	84	3	of	of	ADP
dti-1378	84	4	hydrophilic	hydrophilic	ADJ
dti-1378	84	5	amino	amino	NOUN
dti-1378	84	6	acids	acid	NOUN
dti-1378	84	7	is	be	AUX
dti-1378	84	8	50.7	50.7	NUM
dti-1378	84	9	%	%	NOUN
dti-1378	84	10	while	while	SCONJ
dti-1378	84	11	hydrophobic	hydrophobic	NOUN
dti-1378	84	12	amino	amino	NOUN
dti-1378	84	13	acids	acid	NOUN
dti-1378	84	14	constitute	constitute	VERB
dti-1378	84	15	34.9	34.9	NUM
dti-1378	84	16	%	%	NOUN
dti-1378	84	17	.	.	PUNCT
dti-1378	85	1	the	the	DET
dti-1378	85	2	protein	protein	NOUN
dti-1378	85	3	can	can	AUX
dti-1378	85	4	be	be	AUX
dti-1378	85	5	described	describe	VERB
dti-1378	85	6	as	as	ADP
dti-1378	85	7	moderately	moderately	ADV
dti-1378	85	8	hydrophilic	hydrophilic	ADJ
dti-1378	85	9	.	.	PUNCT
dti-1378	86	1	http://www.la-press.com	http://www.la-press.com	X
dti-1378	87	1	http://www.sbg.bio.ic.ac.uk/phyre2/html/page.cgi?id=news	http://www.sbg.bio.ic.ac.uk/phyre2/html/page.cgi?id=new	NOUN
dti-1378	87	2	http://dicsoft1.physics.iisc.ernet.in/rp/	http://dicsoft1.physics.iisc.ernet.in/rp/	PROPN
dti-1378	87	3	http://mordred.bioc.cam.ac.uk/<223c>rapper/rampage.php	http://mordred.bioc.cam.ac.uk/<223c>rapper/rampage.php	PROPN
dti-1378	87	4	http://www.openrasmol.org/	http://www.openrasmol.org/	X
dti-1378	88	1	http://www.sbg.bio.ic.ac.uk/3dligandsite	http://www.sbg.bio.ic.ac.uk/3dligandsite	PROPN
dti-1378	88	2	drug	drug	NOUN
dti-1378	88	3	target	target	NOUN
dti-1378	88	4	features	feature	NOUN
dti-1378	88	5	of	of	ADP
dti-1378	88	6	schistosoma	schistosoma	ADJ
dti-1378	88	7	adenylyl	adenylyl	NOUN
dti-1378	88	8	cyclase	cyclase	NOUN
dti-1378	88	9	activity	activity	NOUN
dti-1378	88	10	drug	drug	NOUN
dti-1378	88	11	target	target	NOUN
dti-1378	88	12	insights	insight	NOUN
dti-1378	88	13	2012:6	2012:6	NUM
dti-1378	88	14	45	45	NUM
dti-1378	88	15	shown	show	VERB
dti-1378	88	16	to	to	PART
dti-1378	88	17	have	have	VERB
dti-1378	88	18	peak	peak	NOUN
dti-1378	88	19	values	value	NOUN
dti-1378	88	20	greater	great	ADJ
dti-1378	88	21	than	than	ADP
dti-1378	88	22	0	0	NUM
dti-1378	88	23	(	(	PUNCT
dti-1378	88	24	fig	fig	NOUN
dti-1378	88	25	.	.	PUNCT
dti-1378	88	26	1	1	NUM
dti-1378	88	27	)	)	PUNCT
dti-1378	88	28	,	,	PUNCT
dti-1378	88	29	which	which	PRON
dti-1378	88	30	is	be	AUX
dti-1378	88	31	an	an	DET
dti-1378	88	32	indication	indication	NOUN
dti-1378	88	33	that	that	SCONJ
dti-1378	88	34	smp_059340.1	smp_059340.1	PROPN
dti-1378	88	35	could	could	AUX
dti-1378	88	36	be	be	AUX
dti-1378	88	37	drug	drug	NOUN
dti-1378	88	38	target	target	NOUN
dti-1378	88	39	for	for	ADP
dti-1378	88	40	schistosomiasis	schistosomiasis	NOUN
dti-1378	88	41	.	.	PUNCT
dti-1378	89	1	secondary	secondary	ADJ
dti-1378	89	2	structure	structure	NOUN
dti-1378	89	3	characterization	characterization	NOUN
dti-1378	89	4	the	the	DET
dti-1378	89	5	sopma	sopma	NOUN
dti-1378	89	6	tool	tool	NOUN
dti-1378	89	7	at	at	ADP
dti-1378	89	8	expasy	expasy	PROPN
dti-1378	89	9	(	(	PUNCT
dti-1378	89	10	http://expasy.org/tools/	http://expasy.org/tools/	NOUN
dti-1378	89	11	)	)	PUNCT
dti-1378	89	12	was	be	AUX
dti-1378	89	13	used	use	VERB
dti-1378	89	14	to	to	PART
dti-1378	89	15	predict	predict	VERB
dti-1378	89	16	secondary	secondary	ADJ
dti-1378	89	17	structures	structure	NOUN
dti-1378	89	18	(	(	PUNCT
dti-1378	89	19	table	table	NOUN
dti-1378	89	20	3	3	NUM
dti-1378	89	21	)	)	PUNCT
dti-1378	89	22	.	.	PUNCT
dti-1378	90	1	the	the	DET
dti-1378	90	2	data	datum	NOUN
dti-1378	90	3	presented	present	VERB
dti-1378	90	4	here	here	ADV
dti-1378	90	5	indicates	indicate	VERB
dti-1378	90	6	that	that	SCONJ
dti-1378	90	7	this	this	DET
dti-1378	90	8	protein	protein	NOUN
dti-1378	90	9	has	have	AUX
dti-1378	90	10	mixed	mix	VERB
dti-1378	90	11	secondary	secondary	ADJ
dti-1378	90	12	structures	structure	NOUN
dti-1378	90	13	made	make	VERB
dti-1378	90	14	up	up	ADP
dti-1378	90	15	of	of	ADP
dti-1378	90	16	alpha	alpha	ADJ
dti-1378	90	17	helix	helix	NOUN
dti-1378	90	18	(	(	PUNCT
dti-1378	90	19	hh	hh	PROPN
dti-1378	90	20	)	)	PUNCT
dti-1378	90	21	(	(	PUNCT
dti-1378	90	22	54.62	54.62	NUM
dti-1378	90	23	%	%	NOUN
dti-1378	90	24	)	)	PUNCT
dti-1378	90	25	,	,	PUNCT
dti-1378	90	26	extended	extend	VERB
dti-1378	90	27	strand	strand	NOUN
dti-1378	90	28	(	(	PUNCT
dti-1378	90	29	ee	ee	PROPN
dti-1378	90	30	)	)	PUNCT
dti-1378	90	31	(	(	PUNCT
dti-1378	90	32	11.35	11.35	NUM
dti-1378	90	33	%	%	NOUN
dti-1378	90	34	)	)	PUNCT
dti-1378	90	35	,	,	PUNCT
dti-1378	90	36	beta	beta	NOUN
dti-1378	90	37	turn	turn	NOUN
dti-1378	90	38	(	(	PUNCT
dti-1378	90	39	tt	tt	PROPN
dti-1378	90	40	)	)	PUNCT
dti-1378	90	41	(	(	PUNCT
dti-1378	90	42	4.75	4.75	NUM
dti-1378	90	43	%	%	NOUN
dti-1378	90	44	)	)	PUNCT
dti-1378	90	45	and	and	CCONJ
dti-1378	90	46	random	random	ADJ
dti-1378	90	47	coil	coil	NOUN
dti-1378	90	48	(	(	PUNCT
dti-1378	90	49	cc	cc	NOUN
dti-1378	90	50	)	)	PUNCT
dti-1378	90	51	(	(	PUNCT
dti-1378	90	52	29.29	29.29	NUM
dti-1378	90	53	%	%	NOUN
dti-1378	90	54	)	)	PUNCT
dti-1378	90	55	.	.	PUNCT
dti-1378	91	1	the	the	DET
dti-1378	91	2	high	high	ADJ
dti-1378	91	3	alpha	alpha	NOUN
dti-1378	91	4	helix	helix	NOUN
dti-1378	91	5	content	content	NOUN
dti-1378	91	6	may	may	AUX
dti-1378	91	7	be	be	AUX
dti-1378	91	8	due	due	ADJ
dti-1378	91	9	to	to	ADP
dti-1378	91	10	the	the	DET
dti-1378	91	11	rich	rich	ADJ
dti-1378	91	12	alanine	alanine	NOUN
dti-1378	91	13	and	and	CCONJ
dti-1378	91	14	other	other	ADJ
dti-1378	91	15	hydrophobic	hydrophobic	NOUN
dti-1378	91	16	alpha	alpha	NOUN
dti-1378	91	17	helix	helix	NOUN
dti-1378	91	18	residues	residue	NOUN
dti-1378	91	19	,	,	PUNCT
dti-1378	91	20	like	like	ADP
dti-1378	91	21	the	the	DET
dti-1378	91	22	phenylalanine	phenylalanine	NOUN
dti-1378	91	23	(	(	PUNCT
dti-1378	91	24	phe	phe	PROPN
dti-1378	91	25	)	)	PUNCT
dti-1378	91	26	,	,	PUNCT
dti-1378	91	27	leu	leu	PROPN
dti-1378	91	28	and	and	CCONJ
dti-1378	91	29	ile	ile	PROPN
dti-1378	91	30	content	content	NOUN
dti-1378	91	31	of	of	ADP
dti-1378	91	32	the	the	DET
dti-1378	91	33	protein	protein	NOUN
dti-1378	91	34	(	(	PUNCT
dti-1378	91	35	table	table	NOUN
dti-1378	91	36	1	1	NUM
dti-1378	91	37	)	)	PUNCT
dti-1378	91	38	.	.	PUNCT
dti-1378	92	1	the	the	DET
dti-1378	92	2	tmpred	tmpred	ADJ
dti-1378	92	3	server	server	NOUN
dti-1378	92	4	at	at	ADP
dti-1378	92	5	expasy	expasy	NOUN
dti-1378	92	6	(	(	PUNCT
dti-1378	92	7	http://expasy.org/tools/	http://expasy.org/tools/	PROPN
dti-1378	92	8	)	)	PUNCT
dti-1378	92	9	predicted	predict	VERB
dti-1378	92	10	possible	possible	ADJ
dti-1378	92	11	transmembrane	transmembrane	ADJ
dti-1378	92	12	helices	helix	NOUN
dti-1378	92	13	,	,	PUNCT
dti-1378	92	14	with	with	ADP
dti-1378	92	15	two	two	NUM
dti-1378	92	16	possible	possible	ADJ
dti-1378	92	17	orientation	orientation	NOUN
dti-1378	92	18	models	model	NOUN
dti-1378	92	19	(	(	PUNCT
dti-1378	92	20	table	table	NOUN
dti-1378	92	21	4	4	NUM
dti-1378	92	22	)	)	PUNCT
dti-1378	92	23	.	.	PUNCT
dti-1378	93	1	the	the	DET
dti-1378	93	2	first	first	ADJ
dti-1378	93	3	model	model	NOUN
dti-1378	93	4	,	,	PUNCT
dti-1378	93	5	which	which	PRON
dti-1378	93	6	is	be	AUX
dti-1378	93	7	strongly	strongly	ADV
dti-1378	93	8	preferred	prefer	VERB
dti-1378	93	9	based	base	VERB
dti-1378	93	10	on	on	ADP
dti-1378	93	11	a	a	DET
dti-1378	93	12	total	total	ADJ
dti-1378	93	13	score	score	NOUN
dti-1378	93	14	of	of	ADP
dti-1378	93	15	1345	1345	NUM
dti-1378	93	16	,	,	PUNCT
dti-1378	93	17	suggests	suggest	VERB
dti-1378	93	18	that	that	SCONJ
dti-1378	93	19	the	the	DET
dti-1378	93	20	n	n	NOUN
dti-1378	93	21	-	-	PUNCT
dti-1378	93	22	terminus	terminus	NOUN
dti-1378	93	23	of	of	ADP
dti-1378	93	24	the	the	DET
dti-1378	93	25	protein	protein	NOUN
dti-1378	93	26	is	be	AUX
dti-1378	93	27	inside	inside	ADJ
dti-1378	93	28	and	and	CCONJ
dti-1378	93	29	that	that	SCONJ
dti-1378	93	30	the	the	DET
dti-1378	93	31	region	region	NOUN
dti-1378	93	32	starts	start	VERB
dti-1378	93	33	from	from	ADP
dti-1378	93	34	the	the	DET
dti-1378	93	35	amino	amino	NOUN
dti-1378	93	36	acid	acid	NOUN
dti-1378	93	37	residue	residue	NOUN
dti-1378	93	38	218–237	218–237	NUM
dti-1378	93	39	,	,	PUNCT
dti-1378	93	40	spanning	span	VERB
dti-1378	93	41	a	a	DET
dti-1378	93	42	total	total	ADJ
dti-1378	93	43	length	length	NOUN
dti-1378	93	44	of	of	ADP
dti-1378	93	45	20	20	NUM
dti-1378	93	46	amino	amino	NOUN
dti-1378	93	47	acid	acid	NOUN
dti-1378	93	48	residues	residue	NOUN
dti-1378	93	49	in	in	ADP
dti-1378	93	50	an	an	DET
dti-1378	93	51	inside	inside	NOUN
dti-1378	93	52	→	→	PUNCT
dti-1378	93	53	outside	outside	ADV
dti-1378	93	54	(	(	PUNCT
dti-1378	93	55	i	i	PROPN
dti-1378	93	56	→	→	SYM
dti-1378	93	57	o	o	NOUN
dti-1378	93	58	)	)	PUNCT
dti-1378	93	59	orientation	orientation	NOUN
dti-1378	93	60	.	.	PUNCT
dti-1378	94	1	the	the	DET
dti-1378	94	2	alternative	alternative	ADJ
dti-1378	94	3	model	model	NOUN
dti-1378	94	4	suggests	suggest	VERB
dti-1378	94	5	an	an	DET
dti-1378	94	6	outside	outside	NOUN
dti-1378	94	7	→	→	SYM
dti-1378	94	8	inside	inside	ADV
dti-1378	94	9	(	(	PUNCT
dti-1378	94	10	o	o	X
dti-1378	94	11	→	→	SYM
dti-1378	94	12	i	i	NOUN
dti-1378	94	13	)	)	PUNCT
dti-1378	94	14	orientation	orientation	NOUN
dti-1378	94	15	spanning	span	VERB
dti-1378	94	16	23	23	NUM
dti-1378	94	17	amino	amino	NOUN
dti-1378	94	18	acid	acid	NOUN
dti-1378	94	19	residues	residue	NOUN
dti-1378	94	20	from	from	ADP
dti-1378	94	21	position	position	NOUN
dti-1378	94	22	219–241	219–241	NUM
dti-1378	94	23	,	,	PUNCT
dti-1378	94	24	with	with	ADP
dti-1378	94	25	a	a	DET
dti-1378	94	26	lower	low	ADJ
dti-1378	94	27	score	score	NOUN
dti-1378	94	28	of	of	ADP
dti-1378	94	29	854	854	NUM
dti-1378	94	30	.	.	PUNCT
dti-1378	95	1	according	accord	VERB
dti-1378	95	2	to	to	ADP
dti-1378	95	3	the	the	DET
dti-1378	95	4	prediction	prediction	NOUN
dti-1378	95	5	accuracy	accuracy	NOUN
dti-1378	95	6	of	of	ADP
dti-1378	95	7	the	the	DET
dti-1378	95	8	server	server	NOUN
dti-1378	95	9	,	,	PUNCT
dti-1378	95	10	the	the	DET
dti-1378	95	11	protein	protein	NOUN
dti-1378	95	12	has	have	VERB
dti-1378	95	13	transmembrane	transmembrane	ADJ
dti-1378	95	14	helices	helix	NOUN
dti-1378	95	15	in	in	ADP
dti-1378	95	16	an	an	DET
dti-1378	95	17	outside	outside	NOUN
dti-1378	95	18	→	→	SYM
dti-1378	95	19	inside	inside	ADJ
dti-1378	95	20	orientation	orientation	NOUN
dti-1378	95	21	.	.	PUNCT
dti-1378	96	1	the	the	DET
dti-1378	96	2	transmembrane	transmembrane	ADJ
dti-1378	96	3	regions	region	NOUN
dti-1378	96	4	are	be	AUX
dti-1378	96	5	rich	rich	ADJ
dti-1378	96	6	in	in	ADP
dti-1378	96	7	hydrophobic	hydrophobic	NOUN
dti-1378	96	8	amino	amino	NOUN
dti-1378	96	9	acids	acid	NOUN
dti-1378	96	10	,	,	PUNCT
dti-1378	96	11	while	while	SCONJ
dti-1378	96	12	the	the	DET
dti-1378	96	13	hydrophilic	hydrophilic	ADJ
dti-1378	96	14	regions	region	NOUN
dti-1378	96	15	are	be	AUX
dti-1378	96	16	predicted	predict	VERB
dti-1378	96	17	as	as	ADP
dti-1378	96	18	potential	potential	ADJ
dti-1378	96	19	antigenic	antigenic	ADJ
dti-1378	96	20	segments	segment	NOUN
dti-1378	96	21	.	.	PUNCT
dti-1378	97	1	the	the	DET
dti-1378	97	2	transmembrane	transmembrane	ADJ
dti-1378	97	3	regions	region	NOUN
dti-1378	97	4	are	be	AUX
dti-1378	97	5	rich	rich	ADJ
dti-1378	97	6	in	in	ADP
dti-1378	97	7	hydrophobic	hydrophobic	NOUN
dti-1378	97	8	amino	amino	NOUN
dti-1378	97	9	acids	acid	NOUN
dti-1378	97	10	.	.	PUNCT
dti-1378	98	1	this	this	DET
dti-1378	98	2	region	region	NOUN
dti-1378	98	3	is	be	AUX
dti-1378	98	4	well	well	ADV
dti-1378	98	5	indicated	indicate	VERB
dti-1378	98	6	within	within	ADP
dti-1378	98	7	the	the	DET
dti-1378	98	8	kyte	kyte	PROPN
dti-1378	98	9	and	and	CCONJ
dti-1378	98	10	dolittle	dolittle	PROPN
dti-1378	98	11	average	average	ADJ
dti-1378	98	12	hydrophobicity	hydrophobicity	NOUN
dti-1378	98	13	plot	plot	NOUN
dti-1378	98	14	of	of	ADP
dti-1378	98	15	the	the	DET
dti-1378	98	16	protein	protein	NOUN
dti-1378	98	17	residues	residue	NOUN
dti-1378	98	18	(	(	PUNCT
dti-1378	98	19	fig	fig	NOUN
dti-1378	98	20	.	.	NOUN
dti-1378	99	1	1	1	NUM
dti-1378	99	2	)	)	PUNCT
dti-1378	99	3	,	,	PUNCT
dti-1378	99	4	in	in	ADP
dti-1378	99	5	which	which	PRON
dti-1378	99	6	all	all	DET
dti-1378	99	7	points	point	NOUN
dti-1378	99	8	were	be	AUX
dti-1378	99	9	shown	show	VERB
dti-1378	99	10	to	to	PART
dti-1378	99	11	have	have	VERB
dti-1378	99	12	values	value	NOUN
dti-1378	99	13	above	above	ADP
dti-1378	99	14	the	the	DET
dti-1378	99	15	0	0	NUM
dti-1378	99	16	line	line	NOUN
dti-1378	99	17	.	.	PUNCT
dti-1378	100	1	on	on	ADP
dti-1378	100	2	the	the	DET
dti-1378	100	3	same	same	ADJ
dti-1378	100	4	plot	plot	NOUN
dti-1378	100	5	(	(	PUNCT
dti-1378	100	6	fig	fig	NOUN
dti-1378	100	7	.	.	NOUN
dti-1378	100	8	1	1	NUM
dti-1378	100	9	)	)	PUNCT
dti-1378	100	10	the	the	DET
dti-1378	100	11	hoppwoods	hoppwood	NOUN
dti-1378	100	12	scale	scale	NOUN
dti-1378	100	13	predicts	predict	VERB
dti-1378	100	14	the	the	DET
dti-1378	100	15	potential	potential	ADJ
dti-1378	100	16	antigenic	antigenic	ADJ
dti-1378	100	17	regions	region	NOUN
dti-1378	100	18	table	table	NOUN
dti-1378	100	19	2	2	NUM
dti-1378	100	20	.	.	PUNCT
dti-1378	100	21	physicochemical	physicochemical	ADJ
dti-1378	100	22	properties	property	NOUN
dti-1378	100	23	of	of	ADP
dti-1378	100	24	smp_059340.1	smp_059340.1	PROPN
dti-1378	100	25	computed	compute	VERB
dti-1378	100	26	using	use	VERB
dti-1378	100	27	protparam	protparam	PROPN
dti-1378	100	28	server	server	NOUN
dti-1378	100	29	.	.	PUNCT
dti-1378	101	1	protparam	protparam	PROPN
dti-1378	101	2	parameters	parameter	NOUN
dti-1378	101	3	values	value	VERB
dti-1378	101	4	no	no	INTJ
dti-1378	101	5	.	.	PUNCT
dti-1378	101	6	of	of	ADP
dti-1378	101	7	amino	amino	PROPN
dti-1378	101	8	acids	acid	NOUN
dti-1378	101	9	379	379	NUM
dti-1378	101	10	molecular	molecular	ADJ
dti-1378	101	11	weight	weight	NOUN
dti-1378	101	12	44045.5da	44045.5da	NUM
dti-1378	101	13	theoretical	theoretical	ADJ
dti-1378	101	14	pi	pi	NOUN
dti-1378	101	15	8.51	8.51	NUM
dti-1378	101	16	number	number	NOUN
dti-1378	101	17	of	of	ADP
dti-1378	101	18	negative	negative	ADJ
dti-1378	101	19	charge	charge	NOUN
dti-1378	101	20	residues	residue	NOUN
dti-1378	101	21	53	53	NUM
dti-1378	101	22	number	number	NOUN
dti-1378	101	23	of	of	ADP
dti-1378	101	24	positive	positive	ADJ
dti-1378	101	25	charge	charge	NOUN
dti-1378	101	26	residues	residue	VERB
dti-1378	101	27	58	58	NUM
dti-1378	101	28	formula	formula	NOUN
dti-1378	101	29	c1961h3093n547o573s17	c1961h3093n547o573s17	PROPN
dti-1378	101	30	extinction	extinction	NOUN
dti-1378	101	31	coefficient	coefficient	NOUN
dti-1378	101	32	43485	43485	NUM
dti-1378	102	1	m−1	m−1	PROPN
dti-1378	102	2	cm−1	cm−1	NOUN
dti-1378	102	3	estimated	estimate	VERB
dti-1378	102	4	half	half	ADJ
dti-1378	102	5	life	life	NOUN
dti-1378	102	6	30	30	NUM
dti-1378	102	7	hours	hour	NOUN
dti-1378	102	8	instability	instability	NOUN
dti-1378	102	9	index	index	NOUN
dti-1378	102	10	48.15	48.15	NUM
dti-1378	102	11	aliphatic	aliphatic	ADJ
dti-1378	102	12	index	index	NOUN
dti-1378	102	13	82.17	82.17	NUM
dti-1378	102	14	grand	grand	ADJ
dti-1378	102	15	average	average	NOUN
dti-1378	102	16	of	of	ADP
dti-1378	102	17	hydropathicity	hydropathicity	NOUN
dti-1378	102	18	(	(	PUNCT
dti-1378	102	19	gravy	gravy	NOUN
dti-1378	102	20	)	)	PUNCT
dti-1378	102	21	−0.458	−0.458	ADJ
dti-1378	102	22	total	total	ADJ
dti-1378	102	23	number	number	NOUN
dti-1378	102	24	of	of	ADP
dti-1378	102	25	atoms	atom	NOUN
dti-1378	102	26	6191	6191	NUM
dti-1378	102	27	notes	note	VERB
dti-1378	102	28	:	:	PUNCT
dti-1378	102	29	the	the	DET
dti-1378	102	30	physicochemical	physicochemical	ADJ
dti-1378	102	31	parameters	parameter	NOUN
dti-1378	102	32	define	define	VERB
dti-1378	102	33	the	the	DET
dti-1378	102	34	protein	protein	NOUN
dti-1378	102	35	chemical	chemical	NOUN
dti-1378	102	36	and	and	CCONJ
dti-1378	102	37	physical	physical	ADJ
dti-1378	102	38	properties	property	NOUN
dti-1378	102	39	in	in	ADP
dti-1378	102	40	its	its	PRON
dti-1378	102	41	native	native	ADJ
dti-1378	102	42	state	state	NOUN
dti-1378	102	43	.	.	PUNCT
dti-1378	103	1	smp_059340.1	smp_059340.1	PROPN
dti-1378	103	2	has	have	VERB
dti-1378	103	3	a	a	DET
dti-1378	103	4	net	net	ADJ
dti-1378	103	5	positive	positive	ADJ
dti-1378	103	6	charge	charge	NOUN
dti-1378	103	7	and	and	CCONJ
dti-1378	103	8	is	be	AUX
dti-1378	103	9	basic	basic	ADJ
dti-1378	103	10	in	in	ADP
dti-1378	103	11	nature	nature	NOUN
dti-1378	103	12	(	(	PUNCT
dti-1378	103	13	pi	pi	NOUN
dti-1378	103	14	.	.	PUNCT
dti-1378	104	1	7	7	X
dti-1378	104	2	)	)	PUNCT
dti-1378	104	3	.	.	PUNCT
dti-1378	105	1	figure	figure	NOUN
dti-1378	105	2	1	1	NUM
dti-1378	105	3	.	.	PUNCT
dti-1378	106	1	the	the	DET
dti-1378	106	2	hydropathy	hydropathy	ADJ
dti-1378	106	3	plot	plot	NOUN
dti-1378	106	4	for	for	ADP
dti-1378	106	5	schistosoma	schistosoma	ADJ
dti-1378	106	6	mansoni	mansoni	ADJ
dti-1378	106	7	protein	protein	NOUN
dti-1378	106	8	smp_059340.1	smp_059340.1	PROPN
dti-1378	106	9	.	.	PUNCT
dti-1378	106	10	notes	note	VERB
dti-1378	106	11	:	:	PUNCT
dti-1378	106	12	the	the	DET
dti-1378	106	13	yellow	yellow	ADJ
dti-1378	106	14	plot	plot	NOUN
dti-1378	106	15	is	be	AUX
dti-1378	106	16	the	the	DET
dti-1378	106	17	kyte	kyte	PROPN
dti-1378	106	18	-	-	PUNCT
dti-1378	106	19	doolittle	doolittle	PROPN
dti-1378	106	20	hydrophobicity	hydrophobicity	PROPN
dti-1378	106	21	plot	plot	NOUN
dti-1378	106	22	.	.	PUNCT
dti-1378	107	1	sections	section	NOUN
dti-1378	107	2	of	of	ADP
dti-1378	107	3	the	the	DET
dti-1378	107	4	plot	plot	NOUN
dti-1378	107	5	with	with	ADP
dti-1378	107	6	high	high	ADJ
dti-1378	107	7	values	value	NOUN
dti-1378	107	8	.	.	PUNCT
dti-1378	108	1	0.0	0.0	NUM
dti-1378	108	2	are	be	AUX
dti-1378	108	3	highly	highly	ADV
dti-1378	108	4	hydrophobic	hydrophobic	ADJ
dti-1378	108	5	or	or	CCONJ
dti-1378	108	6	membrane	membrane	NOUN
dti-1378	108	7	spanning	span	VERB
dti-1378	108	8	segments	segment	NOUN
dti-1378	108	9	.	.	PUNCT
dti-1378	109	1	the	the	DET
dti-1378	109	2	magenta	magenta	NOUN
dti-1378	109	3	plot	plot	NOUN
dti-1378	109	4	is	be	AUX
dti-1378	109	5	the	the	DET
dti-1378	109	6	hopp	hopp	PROPN
dti-1378	109	7	-	-	PUNCT
dti-1378	109	8	wood	wood	NOUN
dti-1378	109	9	hydrophilicity	hydrophilicity	NOUN
dti-1378	109	10	plot	plot	NOUN
dti-1378	109	11	.	.	PUNCT
dti-1378	110	1	higher	high	ADJ
dti-1378	110	2	values	value	NOUN
dti-1378	110	3	above	above	ADV
dti-1378	110	4	.	.	PUNCT
dti-1378	111	1	0.0	0.0	NUM
dti-1378	111	2	predict	predict	VERB
dti-1378	111	3	rich	rich	ADJ
dti-1378	111	4	charge	charge	NOUN
dti-1378	111	5	exposed	expose	VERB
dti-1378	111	6	regions	region	NOUN
dti-1378	111	7	with	with	ADP
dti-1378	111	8	potential	potential	ADJ
dti-1378	111	9	antigenic	antigenic	ADJ
dti-1378	111	10	site	site	NOUN
dti-1378	111	11	.	.	PUNCT
dti-1378	112	1	smp_059340.1	smp_059340.1	PROPN
dti-1378	112	2	gene	gene	NOUN
dti-1378	112	3	shows	show	VERB
dti-1378	112	4	potential	potential	ADJ
dti-1378	112	5	antigenic	antigenic	ADJ
dti-1378	112	6	sites	site	NOUN
dti-1378	112	7	with	with	ADP
dti-1378	112	8	values	value	NOUN
dti-1378	112	9	$	$	SYM
dti-1378	112	10	2	2	NUM
dti-1378	112	11	.	.	PUNCT
dti-1378	112	12	above	above	ADP
dti-1378	112	13	the	the	DET
dti-1378	112	14	plot	plot	NOUN
dti-1378	112	15	is	be	AUX
dti-1378	112	16	the	the	DET
dti-1378	112	17	smp_059340.1	smp_059340.1	PROPN
dti-1378	112	18	amino	amino	ADJ
dti-1378	112	19	acids	acid	NOUN
dti-1378	112	20	sequence	sequence	NOUN
dti-1378	112	21	.	.	PUNCT
dti-1378	113	1	table	table	NOUN
dti-1378	113	2	3	3	NUM
dti-1378	113	3	.	.	PUNCT
dti-1378	113	4	secondary	secondary	ADJ
dti-1378	113	5	structure	structure	NOUN
dti-1378	113	6	composition	composition	NOUN
dti-1378	113	7	for	for	ADP
dti-1378	113	8	schistosoma	schistosoma	ADJ
dti-1378	113	9	mansoni	mansoni	ADJ
dti-1378	113	10	protein	protein	NOUN
dti-1378	113	11	smp_059340.1	smp_059340.1	PROPN
dti-1378	113	12	.	.	PUNCT
dti-1378	113	13	secondary	secondary	ADJ
dti-1378	113	14	structures	structure	NOUN
dti-1378	113	15	representation	representation	NOUN
dti-1378	113	16	composition	composition	NOUN
dti-1378	113	17	(	(	PUNCT
dti-1378	113	18	%	%	INTJ
dti-1378	113	19	)	)	PUNCT
dti-1378	113	20	alpha	alpha	NOUN
dti-1378	113	21	helix	helix	NOUN
dti-1378	113	22	hh	hh	PROPN
dti-1378	113	23	54.62	54.62	NUM
dti-1378	113	24	extended	extended	ADJ
dti-1378	113	25	stand	stand	NOUN
dti-1378	113	26	ee	ee	ADP
dti-1378	113	27	11.35	11.35	NUM
dti-1378	113	28	beta	beta	NOUN
dti-1378	113	29	turn	turn	NOUN
dti-1378	113	30	tt	tt	PROPN
dti-1378	113	31	4.75	4.75	NUM
dti-1378	113	32	random	random	ADJ
dti-1378	113	33	coil	coil	NOUN
dti-1378	113	34	cc	cc	ADP
dti-1378	113	35	29.29	29.29	NUM
dti-1378	113	36	notes	note	NOUN
dti-1378	113	37	:	:	PUNCT
dti-1378	113	38	secondary	secondary	ADJ
dti-1378	113	39	structure	structure	NOUN
dti-1378	113	40	composition	composition	NOUN
dti-1378	113	41	in	in	ADP
dti-1378	113	42	percentages	percentage	NOUN
dti-1378	113	43	for	for	ADP
dti-1378	113	44	smp_059340.1	smp_059340.1	PROPN
dti-1378	113	45	were	be	AUX
dti-1378	113	46	computed	compute	VERB
dti-1378	113	47	using	use	VERB
dti-1378	113	48	the	the	DET
dti-1378	113	49	sopma	sopma	NOUN
dti-1378	113	50	server	server	NOUN
dti-1378	113	51	at	at	ADP
dti-1378	113	52	expasy	expasy	NOUN
dti-1378	113	53	(	(	PUNCT
dti-1378	113	54	http://expasy.org/	http://expasy.org/	X
dti-1378	113	55	tools/	tools/	NUM
dti-1378	113	56	)	)	PUNCT
dti-1378	113	57	.	.	PUNCT
dti-1378	114	1	the	the	DET
dti-1378	114	2	secondary	secondary	ADJ
dti-1378	114	3	structure	structure	NOUN
dti-1378	114	4	elements	element	NOUN
dti-1378	114	5	are	be	AUX
dti-1378	114	6	composed	compose	VERB
dti-1378	114	7	of	of	ADP
dti-1378	114	8	four	four	NUM
dti-1378	114	9	units	unit	NOUN
dti-1378	114	10	(	(	PUNCT
dti-1378	114	11	alpha	alpha	NOUN
dti-1378	114	12	helix	helix	NOUN
dti-1378	114	13	,	,	PUNCT
dti-1378	114	14	extended	extended	ADJ
dti-1378	114	15	strand	strand	NOUN
dti-1378	114	16	,	,	PUNCT
dti-1378	114	17	beta	beta	NOUN
dti-1378	114	18	turns	turn	NOUN
dti-1378	114	19	and	and	CCONJ
dti-1378	114	20	random	random	ADJ
dti-1378	114	21	coil	coil	NOUN
dti-1378	114	22	)	)	PUNCT
dti-1378	114	23	.	.	PUNCT
dti-1378	115	1	the	the	DET
dti-1378	115	2	structure	structure	NOUN
dti-1378	115	3	is	be	AUX
dti-1378	115	4	made	make	VERB
dti-1378	115	5	up	up	ADP
dti-1378	115	6	of	of	ADP
dti-1378	115	7	more	more	ADJ
dti-1378	115	8	alpha	alpha	ADJ
dti-1378	115	9	helices	helix	NOUN
dti-1378	115	10	and	and	CCONJ
dti-1378	115	11	fewer	few	ADJ
dti-1378	115	12	beta	beta	ADJ
dti-1378	115	13	turns	turn	NOUN
dti-1378	115	14	.	.	PUNCT
dti-1378	116	1	http://www.la-press.com	http://www.la-press.com	X
dti-1378	117	1	http://expasy.org/tools/	http://expasy.org/tools/	PROPN
dti-1378	117	2	http://expasy.org/tools/	http://expasy.org/tools/	PROPN
dti-1378	117	3	mbah	mbah	PROPN
dti-1378	117	4	et	et	PROPN
dti-1378	117	5	al	al	PROPN
dti-1378	117	6	46	46	NUM
dti-1378	117	7	drug	drug	NOUN
dti-1378	117	8	target	target	NOUN
dti-1378	117	9	insights	insight	NOUN
dti-1378	117	10	2012:6	2012:6	ADJ
dti-1378	117	11	acids	acid	NOUN
dti-1378	117	12	while	while	SCONJ
dti-1378	117	13	those	those	PRON
dti-1378	117	14	in	in	ADP
dti-1378	117	15	diamond	diamond	NOUN
dti-1378	117	16	(	(	PUNCT
dti-1378	117	17	red	red	ADJ
dti-1378	117	18	)	)	PUNCT
dti-1378	117	19	are	be	AUX
dti-1378	117	20	the	the	DET
dti-1378	117	21	acidic	acidic	ADJ
dti-1378	117	22	residues	residue	NOUN
dti-1378	117	23	(	(	PUNCT
dti-1378	117	24	polar	polar	ADJ
dti-1378	117	25	residues	residue	NOUN
dti-1378	117	26	;	;	PUNCT
dti-1378	117	27	n	n	CCONJ
dti-1378	117	28	,	,	PUNCT
dti-1378	117	29	t	t	PROPN
dti-1378	117	30	,	,	PUNCT
dti-1378	117	31	s	s	PROPN
dti-1378	117	32	,	,	PUNCT
dti-1378	117	33	d	d	NOUN
dti-1378	117	34	,	,	PUNCT
dti-1378	117	35	q	q	NOUN
dti-1378	117	36	)	)	PUNCT
dti-1378	117	37	.	.	PUNCT
dti-1378	118	1	conserved	conserved	ADJ
dti-1378	118	2	domain	domain	NOUN
dti-1378	118	3	and	and	CCONJ
dti-1378	118	4	functional	functional	ADJ
dti-1378	118	5	analysis	analysis	NOUN
dti-1378	118	6	of	of	ADP
dti-1378	118	7	smp_059340.1	smp_059340.1	PROPN
dti-1378	118	8	the	the	DET
dti-1378	118	9	conserved	conserved	ADJ
dti-1378	118	10	domain	domain	NOUN
dti-1378	118	11	search	search	NOUN
dti-1378	118	12	at	at	ADP
dti-1378	118	13	the	the	DET
dti-1378	118	14	national	national	ADJ
dti-1378	118	15	center	center	NOUN
dti-1378	118	16	for	for	ADP
dti-1378	118	17	biotechnology	biotechnology	NOUN
dti-1378	118	18	information	information	NOUN
dti-1378	118	19	(	(	PUNCT
dti-1378	118	20	ncbi	ncbi	NOUN
dti-1378	118	21	)	)	PUNCT
dti-1378	118	22	website	website	NOUN
dti-1378	118	23	revealed	reveal	VERB
dti-1378	118	24	12	12	NUM
dti-1378	118	25	functional	functional	ADJ
dti-1378	118	26	units	unit	NOUN
dti-1378	118	27	and	and	CCONJ
dti-1378	118	28	their	their	PRON
dti-1378	118	29	full	full	ADJ
dti-1378	118	30	residues	residue	NOUN
dti-1378	118	31	(	(	PUNCT
dti-1378	118	32	table	table	NOUN
dti-1378	118	33	5	5	NUM
dti-1378	118	34	)	)	PUNCT
dti-1378	118	35	.	.	PUNCT
dti-1378	119	1	the	the	DET
dti-1378	119	2	conserved	conserve	VERB
dti-1378	119	3	domain	domain	NOUN
dti-1378	119	4	search	search	NOUN
dti-1378	119	5	for	for	ADP
dti-1378	119	6	smp_059340.1	smp_059340.1	PROPN
dti-1378	119	7	revealed	reveal	VERB
dti-1378	119	8	12	12	NUM
dti-1378	119	9	functional	functional	ADJ
dti-1378	119	10	domains	domain	NOUN
dti-1378	119	11	scattered	scatter	VERB
dti-1378	119	12	within	within	ADP
dti-1378	119	13	its	its	PRON
dti-1378	119	14	amino	amino	ADJ
dti-1378	119	15	acids	acid	NOUN
dti-1378	119	16	sequence	sequence	NOUN
dti-1378	119	17	length	length	NOUN
dti-1378	119	18	(	(	PUNCT
dti-1378	119	19	fig	fig	NOUN
dti-1378	119	20	.	.	PUNCT
dti-1378	120	1	3	3	NUM
dti-1378	120	2	,	,	PUNCT
dti-1378	120	3	table	table	NOUN
dti-1378	120	4	5	5	NUM
dti-1378	120	5	)	)	PUNCT
dti-1378	120	6	.	.	PUNCT
dti-1378	121	1	close	close	ADJ
dti-1378	121	2	observation	observation	NOUN
dti-1378	121	3	of	of	ADP
dti-1378	121	4	table	table	NOUN
dti-1378	121	5	5	5	NUM
dti-1378	121	6	shows	show	VERB
dti-1378	121	7	that	that	SCONJ
dti-1378	121	8	these	these	DET
dti-1378	121	9	functional	functional	ADJ
dti-1378	121	10	units	unit	NOUN
dti-1378	121	11	share	share	VERB
dti-1378	121	12	many	many	ADJ
dti-1378	121	13	residues	residue	NOUN
dti-1378	121	14	in	in	ADP
dti-1378	121	15	common	common	ADJ
dti-1378	121	16	,	,	PUNCT
dti-1378	121	17	suggesting	suggest	VERB
dti-1378	121	18	that	that	SCONJ
dti-1378	121	19	the	the	DET
dti-1378	121	20	smp_059340.1	smp_059340.1	PROPN
dti-1378	121	21	protein	protein	NOUN
dti-1378	121	22	functions	function	NOUN
dti-1378	121	23	as	as	ADP
dti-1378	121	24	a	a	DET
dti-1378	121	25	highly	highly	ADV
dti-1378	121	26	interconnected	interconnected	ADJ
dti-1378	121	27	network	network	NOUN
dti-1378	121	28	of	of	ADP
dti-1378	121	29	functional	functional	ADJ
dti-1378	121	30	units	unit	NOUN
dti-1378	121	31	.	.	PUNCT
dti-1378	122	1	the	the	DET
dti-1378	122	2	next	next	ADJ
dti-1378	122	3	sections	section	NOUN
dti-1378	122	4	provide	provide	VERB
dti-1378	122	5	descriptions	description	NOUN
dti-1378	122	6	of	of	ADP
dti-1378	122	7	the	the	DET
dti-1378	122	8	structural	structural	ADJ
dti-1378	122	9	and	and	CCONJ
dti-1378	122	10	functional	functional	ADJ
dti-1378	122	11	domain	domain	NOUN
dti-1378	122	12	interactions	interaction	NOUN
dti-1378	122	13	of	of	ADP
dti-1378	122	14	the	the	DET
dti-1378	122	15	overall	overall	ADJ
dti-1378	122	16	regulatory	regulatory	ADJ
dti-1378	122	17	mechanism	mechanism	NOUN
dti-1378	122	18	of	of	ADP
dti-1378	122	19	the	the	DET
dti-1378	122	20	adenylyl	adenylyl	NOUN
dti-1378	122	21	cyclase	cyclase	NOUN
dti-1378	122	22	pathway	pathway	NOUN
dti-1378	122	23	that	that	PRON
dti-1378	122	24	controls	control	VERB
dti-1378	122	25	the	the	DET
dti-1378	122	26	general	general	ADJ
dti-1378	122	27	developmental	developmental	ADJ
dti-1378	122	28	processes	process	NOUN
dti-1378	122	29	of	of	ADP
dti-1378	122	30	the	the	DET
dti-1378	122	31	schistosome	schistosome	NOUN
dti-1378	122	32	.	.	PUNCT
dti-1378	123	1	the	the	DET
dti-1378	123	2	smp_059340.1	smp_059340.1	PROPN
dti-1378	123	3	modeled	model	VERB
dti-1378	123	4	3d	3d	NUM
dti-1378	123	5	structural	structural	ADJ
dti-1378	123	6	analysis	analysis	NOUN
dti-1378	123	7	and	and	CCONJ
dti-1378	123	8	verification	verification	NOUN
dti-1378	123	9	the	the	DET
dti-1378	123	10	crystal	crystal	NOUN
dti-1378	123	11	structure	structure	NOUN
dti-1378	123	12	of	of	ADP
dti-1378	123	13	s.	s.	PROPN
dti-1378	123	14	mansoni	mansoni	PROPN
dti-1378	123	15	c4qdc7_schma	c4qdc7_schma	PROPN
dti-1378	123	16	(	(	PUNCT
dti-1378	123	17	smp_059340.1	smp_059340.1	PROPN
dti-1378	123	18	)	)	PUNCT
dti-1378	123	19	has	have	AUX
dti-1378	123	20	not	not	PART
dti-1378	123	21	yet	yet	ADV
dti-1378	123	22	been	be	AUX
dti-1378	123	23	determined	determine	VERB
dti-1378	123	24	;	;	PUNCT
dti-1378	123	25	here	here	ADV
dti-1378	123	26	we	we	PRON
dti-1378	123	27	present	present	VERB
dti-1378	123	28	the	the	DET
dti-1378	123	29	3d	3d	PROPN
dti-1378	123	30	homology	homology	NOUN
dti-1378	123	31	model	model	NOUN
dti-1378	123	32	structure	structure	NOUN
dti-1378	123	33	of	of	ADP
dti-1378	123	34	the	the	DET
dti-1378	123	35	protein	protein	NOUN
dti-1378	123	36	using	use	VERB
dti-1378	123	37	chain	chain	NOUN
dti-1378	123	38	c	c	NOUN
dti-1378	123	39	(	(	PUNCT
dti-1378	123	40	1tl7c	1tl7c	NUM
dti-1378	123	41	)	)	PUNCT
dti-1378	123	42	as	as	ADP
dti-1378	123	43	a	a	DET
dti-1378	123	44	template	template	NOUN
dti-1378	123	45	with	with	ADP
dti-1378	123	46	93	93	NUM
dti-1378	123	47	%	%	NOUN
dti-1378	123	48	of	of	ADP
dti-1378	123	49	the	the	DET
dti-1378	123	50	residues	residue	NOUN
dti-1378	123	51	modeled	model	VERB
dti-1378	123	52	at	at	ADP
dti-1378	123	53	a	a	DET
dti-1378	123	54	90	90	NUM
dti-1378	123	55	%	%	NOUN
dti-1378	123	56	confidence	confidence	NOUN
dti-1378	123	57	level	level	NOUN
dti-1378	123	58	,	,	PUNCT
dti-1378	123	59	as	as	SCONJ
dti-1378	123	60	analyzed	analyze	VERB
dti-1378	123	61	using	use	VERB
dti-1378	123	62	the	the	DET
dti-1378	123	63	phyre	phyre	PROPN
dti-1378	123	64	/	/	SYM
dti-1378	123	65	phyre2	phyre2	PROPN
dti-1378	123	66	server	server	PROPN
dti-1378	123	67	(	(	PUNCT
dti-1378	123	68	fig	fig	NOUN
dti-1378	123	69	.	.	PUNCT
dti-1378	123	70	4a	4a	NUM
dti-1378	123	71	)	)	PUNCT
dti-1378	123	72	.	.	PUNCT
dti-1378	124	1	the	the	DET
dti-1378	124	2	statistics	statistic	NOUN
dti-1378	124	3	of	of	ADP
dti-1378	124	4	smp_059340.1	smp_059340.1	PROPN
dti-1378	124	5	(	(	PUNCT
dti-1378	124	6	target	target	PROPN
dti-1378	124	7	)	)	PUNCT
dti-1378	124	8	and	and	CCONJ
dti-1378	124	9	the	the	DET
dti-1378	124	10	template	template	NOUN
dti-1378	124	11	showing	show	VERB
dti-1378	124	12	their	their	PRON
dti-1378	124	13	comparison	comparison	NOUN
dti-1378	124	14	was	be	AUX
dti-1378	124	15	derived	derive	VERB
dti-1378	124	16	from	from	ADP
dti-1378	124	17	the	the	DET
dti-1378	124	18	swissmodel	swissmodel	PROPN
dti-1378	124	19	server	server	PROPN
dti-1378	124	20	(	(	PUNCT
dti-1378	124	21	table	table	NOUN
dti-1378	124	22	6	6	NUM
dti-1378	124	23	)	)	PUNCT
dti-1378	124	24	.	.	PUNCT
dti-1378	125	1	residue	residue	NOUN
dti-1378	125	2	39	39	NUM
dti-1378	125	3	to	to	ADP
dti-1378	125	4	373	373	NUM
dti-1378	125	5	of	of	ADP
dti-1378	125	6	smp_059340.1	smp_059340.1	PROPN
dti-1378	125	7	was	be	AUX
dti-1378	125	8	aligned	align	VERB
dti-1378	125	9	with	with	ADP
dti-1378	125	10	the	the	DET
dti-1378	125	11	template	template	NOUN
dti-1378	125	12	,	,	PUNCT
dti-1378	125	13	covering	cover	VERB
dti-1378	125	14	88	88	NUM
dti-1378	125	15	%	%	NOUN
dti-1378	125	16	of	of	ADP
dti-1378	125	17	its	its	PRON
dti-1378	125	18	entire	entire	ADJ
dti-1378	125	19	sequence	sequence	NOUN
dti-1378	125	20	length	length	NOUN
dti-1378	125	21	.	.	PUNCT
dti-1378	126	1	irrespective	irrespective	ADV
dti-1378	126	2	of	of	ADP
dti-1378	126	3	the	the	DET
dti-1378	126	4	length	length	NOUN
dti-1378	126	5	difference	difference	NOUN
dti-1378	126	6	between	between	ADP
dti-1378	126	7	the	the	DET
dti-1378	126	8	template	template	NOUN
dti-1378	126	9	and	and	CCONJ
dti-1378	126	10	the	the	DET
dti-1378	126	11	target	target	NOUN
dti-1378	126	12	,	,	PUNCT
dti-1378	126	13	they	they	PRON
dti-1378	126	14	both	both	PRON
dti-1378	126	15	share	share	VERB
dti-1378	126	16	70	70	NUM
dti-1378	126	17	%	%	NOUN
dti-1378	126	18	sequence	sequence	NOUN
dti-1378	126	19	identity	identity	NOUN
dti-1378	126	20	.	.	PUNCT
dti-1378	127	1	the	the	DET
dti-1378	127	2	quality	quality	NOUN
dti-1378	127	3	of	of	ADP
dti-1378	127	4	the	the	DET
dti-1378	127	5	model	model	NOUN
dti-1378	127	6	was	be	AUX
dti-1378	127	7	measured	measure	VERB
dti-1378	127	8	table	table	NOUN
dti-1378	127	9	4	4	NUM
dti-1378	127	10	.	.	PUNCT
dti-1378	127	11	possible	possible	ADJ
dti-1378	127	12	transmembrane	transmembrane	ADJ
dti-1378	127	13	region	region	NOUN
dti-1378	127	14	and	and	CCONJ
dti-1378	127	15	orientation	orientation	NOUN
dti-1378	127	16	for	for	ADP
dti-1378	127	17	schistosoma	schistosoma	ADJ
dti-1378	127	18	mansoni	mansoni	ADJ
dti-1378	127	19	protein	protein	NOUN
dti-1378	127	20	smp_059340.1	smp_059340.1	PROPN
dti-1378	127	21	.	.	PUNCT
dti-1378	127	22	parameter	parameter	PROPN
dti-1378	127	23	inside	inside	ADV
dti-1378	127	24	→	→	PUNCT
dti-1378	127	25	outside	outside	ADV
dti-1378	127	26	(	(	PUNCT
dti-1378	127	27	i	i	PROPN
dti-1378	127	28	→	→	SYM
dti-1378	127	29	o	o	NOUN
dti-1378	127	30	)	)	PUNCT
dti-1378	127	31	outside	outside	ADV
dti-1378	127	32	→	→	SYM
dti-1378	127	33	inside	inside	ADV
dti-1378	127	34	(	(	PUNCT
dti-1378	127	35	o	o	X
dti-1378	127	36	→	→	SYM
dti-1378	127	37	i	i	PROPN
dti-1378	127	38	)	)	PUNCT
dti-1378	127	39	length	length	NOUN
dti-1378	127	40	in	in	ADP
dti-1378	127	41	amino	amino	NOUN
dti-1378	127	42	acid	acid	NOUN
dti-1378	127	43	position	position	NOUN
dti-1378	127	44	218–837	218–837	NUM
dti-1378	127	45	(	(	PUNCT
dti-1378	127	46	20	20	NUM
dti-1378	127	47	residues	residue	NOUN
dti-1378	127	48	)	)	PUNCT
dti-1378	128	1	219–241	219–241	NUM
dti-1378	128	2	(	(	PUNCT
dti-1378	128	3	23	23	NUM
dti-1378	128	4	residues	residue	NOUN
dti-1378	128	5	)	)	PUNCT
dti-1378	128	6	score	score	NOUN
dti-1378	128	7	1345	1345	NUM
dti-1378	128	8	854	854	NUM
dti-1378	128	9	orientation	orientation	NOUN
dti-1378	128	10	preference	preference	NOUN
dti-1378	128	11	strong	strong	ADJ
dti-1378	128	12	(	(	PUNCT
dti-1378	128	13	+	+	ADJ
dti-1378	128	14	+	+	ADJ
dti-1378	128	15	)	)	PUNCT
dti-1378	128	16	weak	weak	ADJ
dti-1378	128	17	(	(	PUNCT
dti-1378	128	18	+	+	NOUN
dti-1378	128	19	)	)	PUNCT
dti-1378	128	20	notes	note	NOUN
dti-1378	128	21	:	:	PUNCT
dti-1378	128	22	possible	possible	ADJ
dti-1378	128	23	transmembrane	transmembrane	ADJ
dti-1378	128	24	region	region	NOUN
dti-1378	128	25	and	and	CCONJ
dti-1378	128	26	orientation	orientation	NOUN
dti-1378	128	27	identified	identify	VERB
dti-1378	128	28	by	by	ADP
dti-1378	128	29	tmpred	tmpred	ADJ
dti-1378	128	30	server	server	NOUN
dti-1378	128	31	at	at	ADP
dti-1378	128	32	expasy	expasy	NOUN
dti-1378	128	33	(	(	PUNCT
dti-1378	128	34	http://expasy.org/tools/	http://expasy.org/tools/	PROPN
dti-1378	128	35	)	)	PUNCT
dti-1378	128	36	.	.	PUNCT
dti-1378	129	1	two	two	NUM
dti-1378	129	2	transmembrane	transmembrane	ADJ
dti-1378	129	3	orientations	orientation	NOUN
dti-1378	129	4	were	be	AUX
dti-1378	129	5	predicted	predict	VERB
dti-1378	129	6	.	.	PUNCT
dti-1378	130	1	the	the	DET
dti-1378	130	2	protein	protein	NOUN
dti-1378	130	3	strongly	strongly	ADV
dti-1378	130	4	preferred	prefer	VERB
dti-1378	130	5	inside	inside	ADV
dti-1378	130	6	→	→	PUNCT
dti-1378	130	7	outside	outside	ADV
dti-1378	130	8	(	(	PUNCT
dti-1378	130	9	i	i	PROPN
dti-1378	130	10	→	→	SYM
dti-1378	130	11	o	o	NOUN
dti-1378	130	12	)	)	PUNCT
dti-1378	130	13	orientation	orientation	NOUN
dti-1378	130	14	base	base	NOUN
dti-1378	130	15	on	on	ADP
dti-1378	130	16	a	a	DET
dti-1378	130	17	total	total	ADJ
dti-1378	130	18	score	score	NOUN
dti-1378	130	19	of	of	ADP
dti-1378	130	20	1345	1345	NUM
dti-1378	130	21	with	with	ADP
dti-1378	130	22	20	20	NUM
dti-1378	130	23	amino	amino	NOUN
dti-1378	130	24	acid	acid	NOUN
dti-1378	130	25	residues	residue	NOUN
dti-1378	130	26	spanning	span	VERB
dti-1378	130	27	residues	residue	NOUN
dti-1378	130	28	218–237	218–237	NUM
dti-1378	130	29	.	.	PUNCT
dti-1378	131	1	the	the	DET
dti-1378	131	2	alternative	alternative	ADJ
dti-1378	131	3	model	model	NOUN
dti-1378	131	4	suggest	suggest	VERB
dti-1378	131	5	an	an	DET
dti-1378	131	6	outside	outside	NOUN
dti-1378	131	7	→	→	SYM
dti-1378	131	8	inside	inside	ADV
dti-1378	131	9	(	(	PUNCT
dti-1378	131	10	o	o	X
dti-1378	131	11	→	→	SYM
dti-1378	131	12	i	i	NOUN
dti-1378	131	13	)	)	PUNCT
dti-1378	131	14	orientation	orientation	NOUN
dti-1378	131	15	spanning	span	VERB
dti-1378	131	16	23	23	NUM
dti-1378	131	17	amino	amino	NOUN
dti-1378	131	18	acid	acid	NOUN
dti-1378	131	19	residues	residue	NOUN
dti-1378	131	20	from	from	ADP
dti-1378	131	21	position	position	NOUN
dti-1378	131	22	219–241	219–241	NUM
dti-1378	131	23	with	with	ADP
dti-1378	131	24	a	a	DET
dti-1378	131	25	lower	low	ADJ
dti-1378	131	26	score	score	NOUN
dti-1378	131	27	of	of	ADP
dti-1378	131	28	854	854	NUM
dti-1378	131	29	.	.	PUNCT
dti-1378	132	1	p	p	X
dti-1378	132	2	f	f	X
dti-1378	132	3	v	v	INTJ
dti-1378	132	4	i	i	NOUN
dti-1378	132	5	l	l	NOUN
dti-1378	132	6	l	l	NOUN
dti-1378	133	1	p	p	X
dti-1378	133	2	y	y	PROPN
dti-1378	133	3	y	y	PROPN
dti-1378	133	4	g	g	PROPN
dti-1378	133	5	a	a	PRON
dti-1378	133	6	a	a	DET
dti-1378	133	7	a	a	NOUN
dti-1378	133	8	c	c	NOUN
dti-1378	134	1	k	k	PROPN
dti-1378	134	2	k	k	PROPN
dti-1378	135	1	n	n	PROPN
dti-1378	135	2	s	s	X
dti-1378	135	3	d	d	X
dti-1378	135	4	e	e	X
dti-1378	135	5	figure	figure	NOUN
dti-1378	135	6	2	2	NUM
dti-1378	135	7	.	.	PUNCT
dti-1378	135	8	transmembrane	transmembrane	ADJ
dti-1378	135	9	helices	helix	NOUN
dti-1378	135	10	plot	plot	NOUN
dti-1378	135	11	for	for	ADP
dti-1378	135	12	schistosoma	schistosoma	ADJ
dti-1378	135	13	mansoni	mansoni	ADJ
dti-1378	135	14	smp_059340.1	smp_059340.1	PROPN
dti-1378	135	15	.	.	PUNCT
dti-1378	135	16	notes	note	VERB
dti-1378	135	17	:	:	PUNCT
dti-1378	135	18	the	the	DET
dti-1378	135	19	transmembrane	transmembrane	NOUN
dti-1378	135	20	helices	helix	NOUN
dti-1378	135	21	were	be	AUX
dti-1378	135	22	predicted	predict	VERB
dti-1378	135	23	with	with	ADP
dti-1378	135	24	tmpred	tmpred	ADJ
dti-1378	135	25	server	server	NOUN
dti-1378	135	26	at	at	ADP
dti-1378	135	27	expasy	expasy	NOUN
dti-1378	135	28	(	(	PUNCT
dti-1378	135	29	http://expasy.org/tools/	http://expasy.org/tools/	PROPN
dti-1378	135	30	)	)	PUNCT
dti-1378	135	31	.	.	PUNCT
dti-1378	136	1	the	the	DET
dti-1378	136	2	popwheel	popwheel	NOUN
dti-1378	136	3	displays	display	VERB
dti-1378	136	4	the	the	DET
dti-1378	136	5	20	20	NUM
dti-1378	136	6	amino	amino	ADJ
dti-1378	136	7	acids	acid	NOUN
dti-1378	136	8	transmembrane	transmembrane	NOUN
dti-1378	136	9	sequence	sequence	NOUN
dti-1378	136	10	in	in	ADP
dti-1378	136	11	a	a	DET
dti-1378	136	12	helical	helical	ADJ
dti-1378	136	13	representation	representation	NOUN
dti-1378	136	14	as	as	SCONJ
dti-1378	136	15	if	if	SCONJ
dti-1378	136	16	looking	look	VERB
dti-1378	136	17	down	down	ADP
dti-1378	136	18	the	the	DET
dti-1378	136	19	axis	axis	NOUN
dti-1378	136	20	of	of	ADP
dti-1378	136	21	the	the	DET
dti-1378	136	22	helix	helix	NOUN
dti-1378	136	23	.	.	PUNCT
dti-1378	137	1	this	this	DET
dti-1378	137	2	representation	representation	NOUN
dti-1378	137	3	is	be	AUX
dti-1378	137	4	useful	useful	ADJ
dti-1378	137	5	for	for	ADP
dti-1378	137	6	highlighting	highlight	VERB
dti-1378	137	7	amphipathicity	amphipathicity	NOUN
dti-1378	137	8	and	and	CCONJ
dti-1378	137	9	other	other	ADJ
dti-1378	137	10	properties	property	NOUN
dti-1378	137	11	of	of	ADP
dti-1378	137	12	residues	residue	NOUN
dti-1378	137	13	around	around	ADP
dti-1378	137	14	a	a	DET
dti-1378	137	15	helix	helix	NOUN
dti-1378	137	16	.	.	PUNCT
dti-1378	138	1	the	the	DET
dti-1378	138	2	aliphatic	aliphatic	ADJ
dti-1378	138	3	residues	residue	NOUN
dti-1378	138	4	in	in	ADP
dti-1378	138	5	blue	blue	ADJ
dti-1378	138	6	square	square	NOUN
dti-1378	138	7	(	(	PUNCT
dti-1378	138	8	i	i	PROPN
dti-1378	138	9	,	,	PUNCT
dti-1378	138	10	l	l	PROPN
dti-1378	138	11	,	,	PUNCT
dti-1378	138	12	v	v	NOUN
dti-1378	138	13	)	)	PUNCT
dti-1378	138	14	and	and	CCONJ
dti-1378	138	15	the	the	DET
dti-1378	138	16	violet	violet	ADJ
dti-1378	138	17	residues	residue	NOUN
dti-1378	138	18	(	(	PUNCT
dti-1378	138	19	c	c	X
dti-1378	138	20	,	,	PUNCT
dti-1378	138	21	a	a	DET
dti-1378	138	22	,	,	PUNCT
dti-1378	138	23	w	w	PROPN
dti-1378	138	24	,	,	PUNCT
dti-1378	138	25	f	f	PROPN
dti-1378	138	26	,	,	PUNCT
dti-1378	138	27	y	y	PROPN
dti-1378	138	28	)	)	PUNCT
dti-1378	138	29	are	be	AUX
dti-1378	138	30	hydrophobic	hydrophobic	ADJ
dti-1378	138	31	,	,	PUNCT
dti-1378	138	32	while	while	SCONJ
dti-1378	138	33	hydrophilic	hydrophilic	ADJ
dti-1378	138	34	residues	residue	NOUN
dti-1378	138	35	are	be	AUX
dti-1378	138	36	marked	mark	VERB
dti-1378	138	37	with	with	ADP
dti-1378	138	38	diamond	diamond	NOUN
dti-1378	138	39	(	(	PUNCT
dti-1378	138	40	red	red	ADJ
dti-1378	138	41	)	)	PUNCT
dti-1378	138	42	.	.	PUNCT
dti-1378	139	1	the	the	DET
dti-1378	139	2	positive	positive	ADJ
dti-1378	139	3	charge	charge	NOUN
dti-1378	139	4	residues	residue	NOUN
dti-1378	139	5	(	(	PUNCT
dti-1378	139	6	both	both	PRON
dti-1378	139	7	k	k	X
dti-1378	139	8	)	)	PUNCT
dti-1378	139	9	are	be	AUX
dti-1378	139	10	with	with	ADP
dti-1378	139	11	octagonal	octagonal	ADJ
dti-1378	139	12	shape	shape	NOUN
dti-1378	139	13	.	.	PUNCT
dti-1378	140	1	of	of	ADP
dti-1378	140	2	the	the	DET
dti-1378	140	3	protein	protein	NOUN
dti-1378	140	4	.	.	PUNCT
dti-1378	141	1	the	the	DET
dti-1378	141	2	hydrophilic	hydrophilic	ADJ
dti-1378	141	3	regions	region	NOUN
dti-1378	141	4	have	have	VERB
dti-1378	141	5	values	value	NOUN
dti-1378	141	6	greater	great	ADJ
dti-1378	141	7	than	than	ADP
dti-1378	141	8	0	0	NUM
dti-1378	141	9	,	,	PUNCT
dti-1378	141	10	and	and	CCONJ
dti-1378	141	11	they	they	PRON
dti-1378	141	12	are	be	AUX
dti-1378	141	13	predicted	predict	VERB
dti-1378	141	14	as	as	ADP
dti-1378	141	15	potential	potential	ADJ
dti-1378	141	16	antigenic	antigenic	ADJ
dti-1378	141	17	regions	region	NOUN
dti-1378	141	18	.	.	PUNCT
dti-1378	142	1	on	on	ADP
dti-1378	142	2	the	the	DET
dti-1378	142	3	kyte	kyte	PROPN
dti-1378	142	4	-	-	PUNCT
dti-1378	142	5	dolittle	dolittle	PROPN
dti-1378	142	6	plot	plot	NOUN
dti-1378	142	7	,	,	PUNCT
dti-1378	142	8	regions	region	NOUN
dti-1378	142	9	with	with	ADP
dti-1378	142	10	values	value	NOUN
dti-1378	142	11	less	less	ADJ
dti-1378	142	12	than	than	ADP
dti-1378	142	13	0	0	NUM
dti-1378	142	14	are	be	AUX
dti-1378	142	15	hydrophilic	hydrophilic	ADJ
dti-1378	142	16	in	in	ADP
dti-1378	142	17	nature	nature	NOUN
dti-1378	142	18	.	.	PUNCT
dti-1378	143	1	hence	hence	ADV
dti-1378	143	2	the	the	DET
dti-1378	143	3	antigenic	antigenic	ADJ
dti-1378	143	4	regions	region	NOUN
dti-1378	143	5	of	of	ADP
dti-1378	143	6	proteins	protein	NOUN
dti-1378	143	7	are	be	AUX
dti-1378	143	8	hydrophilic	hydrophilic	ADJ
dti-1378	143	9	.	.	PUNCT
dti-1378	144	1	the	the	DET
dti-1378	144	2	transmembrane	transmembrane	NOUN
dti-1378	144	3	helices	helix	NOUN
dti-1378	144	4	predicted	predict	VERB
dti-1378	144	5	using	use	VERB
dti-1378	144	6	the	the	DET
dti-1378	144	7	prediction	prediction	NOUN
dti-1378	144	8	of	of	ADP
dti-1378	144	9	transmembrane	transmembrane	ADJ
dti-1378	144	10	region	region	NOUN
dti-1378	144	11	and	and	CCONJ
dti-1378	144	12	orientation	orientation	NOUN
dti-1378	144	13	(	(	PUNCT
dti-1378	144	14	tmpred	tmpred	ADJ
dti-1378	144	15	)	)	PUNCT
dti-1378	144	16	server	server	NOUN
dti-1378	144	17	were	be	AUX
dti-1378	144	18	visualized	visualize	VERB
dti-1378	144	19	with	with	ADP
dti-1378	144	20	the	the	DET
dti-1378	144	21	pepwheel	pepwheel	NOUN
dti-1378	144	22	tool	tool	NOUN
dti-1378	144	23	(	(	PUNCT
dti-1378	144	24	fig	fig	NOUN
dti-1378	144	25	.	.	NOUN
dti-1378	145	1	2	2	NUM
dti-1378	145	2	)	)	PUNCT
dti-1378	145	3	using	use	VERB
dti-1378	145	4	the	the	DET
dti-1378	145	5	20	20	NUM
dti-1378	145	6	amino	amino	NOUN
dti-1378	145	7	acids	acid	NOUN
dti-1378	145	8	in	in	ADP
dti-1378	145	9	an	an	DET
dti-1378	145	10	inside	inside	NOUN
dti-1378	145	11	→	→	SYM
dti-1378	145	12	outer	outer	ADJ
dti-1378	145	13	orientation	orientation	NOUN
dti-1378	145	14	.	.	PUNCT
dti-1378	146	1	the	the	DET
dti-1378	146	2	residues	residue	NOUN
dti-1378	146	3	in	in	ADP
dti-1378	146	4	the	the	DET
dti-1378	146	5	blue	blue	ADJ
dti-1378	146	6	square	square	NOUN
dti-1378	146	7	(	(	PUNCT
dti-1378	146	8	i	i	PROPN
dti-1378	146	9	,	,	PUNCT
dti-1378	146	10	l	l	PROPN
dti-1378	146	11	,	,	PUNCT
dti-1378	146	12	v	v	NOUN
dti-1378	146	13	)	)	PUNCT
dti-1378	146	14	and	and	CCONJ
dti-1378	146	15	the	the	DET
dti-1378	146	16	violet	violet	ADJ
dti-1378	146	17	residues	residue	NOUN
dti-1378	146	18	(	(	PUNCT
dti-1378	146	19	c	c	X
dti-1378	146	20	,	,	PUNCT
dti-1378	146	21	a	a	DET
dti-1378	146	22	,	,	PUNCT
dti-1378	146	23	w	w	PROPN
dti-1378	146	24	,	,	PUNCT
dti-1378	146	25	f	f	PROPN
dti-1378	146	26	,	,	PUNCT
dti-1378	146	27	y	y	PROPN
dti-1378	146	28	)	)	PUNCT
dti-1378	146	29	represent	represent	VERB
dti-1378	146	30	the	the	DET
dti-1378	146	31	hydrophobic	hydrophobic	NOUN
dti-1378	146	32	amino	amino	NOUN
dti-1378	146	33	http://www.la-press.com	http://www.la-press.com	X
dti-1378	147	1	http://expasy.org/tools/	http://expasy.org/tools/	VERB
dti-1378	147	2	drug	drug	NOUN
dti-1378	147	3	target	target	NOUN
dti-1378	147	4	features	feature	NOUN
dti-1378	147	5	of	of	ADP
dti-1378	147	6	schistosoma	schistosoma	ADJ
dti-1378	147	7	adenylyl	adenylyl	NOUN
dti-1378	147	8	cyclase	cyclase	NOUN
dti-1378	147	9	activity	activity	NOUN
dti-1378	147	10	drug	drug	NOUN
dti-1378	147	11	target	target	NOUN
dti-1378	147	12	insights	insight	NOUN
dti-1378	147	13	2012:6	2012:6	NUM
dti-1378	147	14	47	47	NUM
dti-1378	147	15	using	use	VERB
dti-1378	147	16	the	the	DET
dti-1378	147	17	qmean	qmean	PROPN
dti-1378	147	18	score4	score4	PROPN
dti-1378	147	19	.	.	PUNCT
dti-1378	148	1	the	the	DET
dti-1378	148	2	qmean	qmean	PROPN
dti-1378	148	3	score4	score4	PROPN
dti-1378	148	4	measures	measure	VERB
dti-1378	148	5	the	the	DET
dti-1378	148	6	global	global	ADJ
dti-1378	148	7	score	score	NOUN
dti-1378	148	8	of	of	ADP
dti-1378	148	9	the	the	DET
dti-1378	148	10	whole	whole	ADJ
dti-1378	148	11	model	model	NOUN
dti-1378	148	12	,	,	PUNCT
dti-1378	148	13	reflecting	reflect	VERB
dti-1378	148	14	the	the	DET
dti-1378	148	15	predicted	predict	VERB
dti-1378	148	16	model	model	NOUN
dti-1378	148	17	reliability	reliability	NOUN
dti-1378	148	18	range	range	NOUN
dti-1378	148	19	from	from	ADP
dti-1378	148	20	0	0	NUM
dti-1378	148	21	to	to	ADP
dti-1378	148	22	1	1	NUM
dti-1378	148	23	.	.	PUNCT
dti-1378	149	1	the	the	DET
dti-1378	149	2	modeled	model	VERB
dti-1378	149	3	smp_059340.1	smp_059340.1	PROPN
dti-1378	149	4	structure	structure	NOUN
dti-1378	149	5	had	have	VERB
dti-1378	149	6	qmean	qmean	ADJ
dti-1378	149	7	score4	score4	NOUN
dti-1378	149	8	value	value	NOUN
dti-1378	149	9	of	of	ADP
dti-1378	149	10	0.68	0.68	NUM
dti-1378	149	11	,	,	PUNCT
dti-1378	149	12	suggesting	suggest	VERB
dti-1378	149	13	that	that	SCONJ
dti-1378	149	14	it	it	PRON
dti-1378	149	15	is	be	AUX
dti-1378	149	16	a	a	DET
dti-1378	149	17	good	good	ADJ
dti-1378	149	18	,	,	PUNCT
dti-1378	149	19	biologically	biologically	ADV
dti-1378	149	20	informative	informative	ADJ
dti-1378	149	21	model	model	NOUN
dti-1378	149	22	.	.	PUNCT
dti-1378	150	1	the	the	DET
dti-1378	150	2	swiss	swiss	ADJ
dti-1378	150	3	model	model	NOUN
dti-1378	150	4	server	server	NOUN
dti-1378	150	5	estimate	estimate	NOUN
dti-1378	150	6	per	per	ADP
dti-1378	150	7	residue	residue	NOUN
dti-1378	150	8	inaccuracy	inaccuracy	NOUN
dti-1378	150	9	was	be	AUX
dti-1378	150	10	visualized	visualize	VERB
dti-1378	150	11	based	base	VERB
dti-1378	150	12	on	on	ADP
dti-1378	150	13	secondary	secondary	ADJ
dti-1378	150	14	structural	structural	ADJ
dti-1378	150	15	components	component	NOUN
dti-1378	150	16	.	.	PUNCT
dti-1378	151	1	the	the	DET
dti-1378	151	2	color	color	NOUN
dti-1378	151	3	gradient	gradient	NOUN
dti-1378	151	4	ranges	range	VERB
dti-1378	151	5	from	from	ADP
dti-1378	151	6	blue	blue	ADJ
dti-1378	151	7	(	(	PUNCT
dti-1378	151	8	more	more	ADV
dti-1378	151	9	reliable	reliable	ADJ
dti-1378	151	10	region	region	NOUN
dti-1378	151	11	)	)	PUNCT
dti-1378	151	12	to	to	ADP
dti-1378	151	13	red	red	ADJ
dti-1378	151	14	(	(	PUNCT
dti-1378	151	15	potential	potential	ADJ
dti-1378	151	16	unreliable	unreliable	ADJ
dti-1378	151	17	regions	region	NOUN
dti-1378	151	18	;	;	PUNCT
dti-1378	151	19	fig	fig	NOUN
dti-1378	151	20	.	.	PUNCT
dti-1378	152	1	4b	4b	PROPN
dti-1378	152	2	)	)	PUNCT
dti-1378	152	3	.	.	PUNCT
dti-1378	153	1	a	a	DET
dti-1378	153	2	greater	great	ADJ
dti-1378	153	3	proportion	proportion	NOUN
dti-1378	153	4	of	of	ADP
dti-1378	153	5	unreliable	unreliable	ADJ
dti-1378	153	6	regions	region	NOUN
dti-1378	153	7	were	be	AUX
dti-1378	153	8	located	locate	VERB
dti-1378	153	9	around	around	ADP
dti-1378	153	10	the	the	DET
dti-1378	153	11	loops	loop	NOUN
dti-1378	153	12	and	and	CCONJ
dti-1378	153	13	random	random	ADJ
dti-1378	153	14	coils	coil	NOUN
dti-1378	153	15	,	,	PUNCT
dti-1378	153	16	which	which	PRON
dti-1378	153	17	are	be	AUX
dti-1378	153	18	usually	usually	ADV
dti-1378	153	19	the	the	DET
dti-1378	153	20	most	most	ADV
dti-1378	153	21	difficult	difficult	ADJ
dti-1378	153	22	parts	part	NOUN
dti-1378	153	23	to	to	PART
dti-1378	153	24	predict	predict	VERB
dti-1378	153	25	.	.	PUNCT
dti-1378	154	1	the	the	DET
dti-1378	154	2	sequence	sequence	NOUN
dti-1378	154	3	alignment	alignment	NOUN
dti-1378	154	4	of	of	ADP
dti-1378	154	5	the	the	DET
dti-1378	154	6	template	template	NOUN
dti-1378	154	7	and	and	CCONJ
dti-1378	154	8	smp_059340.1	smp_059340.1	PROPN
dti-1378	154	9	(	(	PUNCT
dti-1378	154	10	target	target	NOUN
dti-1378	154	11	)	)	PUNCT
dti-1378	154	12	generated	generate	VERB
dti-1378	154	13	by	by	ADP
dti-1378	154	14	hmm	hmm	PROPN
dti-1378	154	15	-	-	PUNCT
dti-1378	154	16	hmm	hmm	INTJ
dti-1378	154	17	matching	matching	NOUN
dti-1378	154	18	using	use	VERB
dti-1378	154	19	the	the	DET
dti-1378	154	20	phyre	phyre	PROPN
dti-1378	154	21	/	/	SYM
dti-1378	154	22	phyre2	phyre2	PROPN
dti-1378	154	23	server	server	NOUN
dti-1378	154	24	shows	show	VERB
dti-1378	154	25	that	that	SCONJ
dti-1378	154	26	the	the	DET
dti-1378	154	27	alpha	alpha	NOUN
dti-1378	154	28	helices	helix	NOUN
dti-1378	154	29	and	and	CCONJ
dti-1378	154	30	beta	beta	ADJ
dti-1378	154	31	strands	strand	NOUN
dti-1378	154	32	were	be	AUX
dti-1378	154	33	predicted	predict	VERB
dti-1378	154	34	with	with	ADP
dti-1378	154	35	approximate	approximate	ADJ
dti-1378	154	36	better	well	ADJ
dti-1378	154	37	confidence	confidence	NOUN
dti-1378	154	38	values	value	NOUN
dti-1378	154	39	than	than	ADP
dti-1378	154	40	the	the	DET
dti-1378	154	41	rantable	rantable	ADJ
dti-1378	154	42	5	5	NUM
dti-1378	154	43	.	.	PUNCT
dti-1378	154	44	function	function	NOUN
dti-1378	154	45	of	of	ADP
dti-1378	154	46	the	the	DET
dti-1378	154	47	12	12	NUM
dti-1378	154	48	domains	domain	NOUN
dti-1378	154	49	and	and	CCONJ
dti-1378	154	50	their	their	PRON
dti-1378	154	51	constituted	constitute	VERB
dti-1378	154	52	residues	residue	NOUN
dti-1378	154	53	for	for	ADP
dti-1378	154	54	schistosoma	schistosoma	ADJ
dti-1378	154	55	mansoni	mansoni	ADJ
dti-1378	154	56	protein	protein	NOUN
dti-1378	154	57	smp_059340.1	smp_059340.1	PROPN
dti-1378	154	58	.	.	PUNCT
dti-1378	155	1	conserved	conserved	ADJ
dti-1378	155	2	domain	domain	NOUN
dti-1378	155	3	component	component	NOUN
dti-1378	155	4	residue(s	residue(s	PROPN
dti-1378	155	5	)	)	PUNCT
dti-1378	155	6	function	function	NOUN
dti-1378	155	7	mg2+/gtp	mg2+/gtp	NOUN
dti-1378	155	8	binding	bind	VERB
dti-1378	155	9	site	site	NOUN
dti-1378	155	10	g46	g46	NOUN
dti-1378	155	11	,	,	PUNCT
dti-1378	155	12	g51	g51	ADJ
dti-1378	155	13	,	,	PUNCT
dti-1378	155	14	k52	k52	NOUN
dti-1378	155	15	,	,	PUNCT
dti-1378	155	16	s53	s53	NOUN
dti-1378	155	17	,	,	PUNCT
dti-1378	155	18	t188	t188	PROPN
dti-1378	155	19	,	,	PUNCT
dti-1378	155	20	d207	d207	PROPN
dti-1378	155	21	,	,	PUNCT
dti-1378	155	22	g210	g210	PROPN
dti-1378	155	23	,	,	PUNCT
dti-1378	155	24	n276	n276	PROPN
dti-1378	155	25	,	,	PUNCT
dti-1378	155	26	k277	k277	PROPN
dti-1378	155	27	,	,	PUNCT
dti-1378	155	28	d279	d279	PROPN
dti-1378	155	29	,	,	PUNCT
dti-1378	155	30	c350	c350	PROPN
dti-1378	155	31	,	,	PUNCT
dti-1378	155	32	a351	a351	PROPN
dti-1378	155	33	the	the	DET
dti-1378	155	34	mg2	mg2	PROPN
dti-1378	155	35	+	+	PROPN
dti-1378	155	36	interacts	interact	VERB
dti-1378	155	37	with	with	ADP
dti-1378	155	38	alpha	alpha	ADJ
dti-1378	155	39	subunits	subunit	NOUN
dti-1378	155	40	of	of	ADP
dti-1378	155	41	the	the	DET
dti-1378	155	42	g	g	PROPN
dti-1378	155	43	proteins	protein	NOUN
dti-1378	155	44	in	in	ADP
dti-1378	155	45	the	the	DET
dti-1378	155	46	present	present	NOUN
dti-1378	155	47	of	of	ADP
dti-1378	155	48	gtp	gtp	NOUN
dti-1378	155	49	to	to	PART
dti-1378	155	50	form	form	VERB
dti-1378	155	51	a	a	DET
dti-1378	155	52	complex	complex	NOUN
dti-1378	155	53	from	from	ADP
dti-1378	155	54	which	which	PRON
dti-1378	155	55	nucleotide	nucleotide	NOUN
dti-1378	155	56	dissociate	dissociate	VERB
dti-1378	155	57	slowly	slowly	ADV
dti-1378	155	58	adenylyl	adenylyl	ADJ
dti-1378	155	59	cyclase	cyclase	NOUN
dti-1378	155	60	interaction	interaction	NOUN
dti-1378	155	61	site	site	NOUN
dti-1378	155	62	i191	i191	PROPN
dti-1378	155	63	,	,	PUNCT
dti-1378	155	64	r216	r216	PROPN
dti-1378	155	65	,	,	PUNCT
dti-1378	155	66	i219	i219	PROPN
dti-1378	155	67	,	,	PUNCT
dti-1378	155	68	q220	q220	PROPN
dti-1378	155	69	,	,	PUNCT
dti-1378	155	70	n223	n223	PROPN
dti-1378	155	71	stimulates	stimulate	VERB
dti-1378	155	72	the	the	DET
dti-1378	155	73	adenylyl	adenylyl	NOUN
dti-1378	155	74	cyclase	cyclase	NOUN
dti-1378	155	75	by	by	ADP
dti-1378	155	76	binding	bind	VERB
dti-1378	155	77	to	to	ADP
dti-1378	155	78	it	it	PRON
dti-1378	155	79	beta	beta	NOUN
dti-1378	155	80	—	—	PUNCT
dti-1378	155	81	gamma	gamma	NOUN
dti-1378	155	82	complex	complex	ADJ
dti-1378	155	83	interaction	interaction	NOUN
dti-1378	155	84	site	site	NOUN
dti-1378	155	85	s189	s189	PROPN
dti-1378	155	86	,	,	PUNCT
dti-1378	155	87	i191	i191	PROPN
dti-1378	155	88	,	,	PUNCT
dti-1378	155	89	e193	e193	PROPN
dti-1378	155	90	,	,	PUNCT
dti-1378	155	91	h204	h204	PROPN
dti-1378	155	92	,	,	PUNCT
dti-1378	155	93	f206	f206	PROPN
dti-1378	155	94	,	,	PUNCT
dti-1378	155	95	g210	g210	PROPN
dti-1378	155	96	,	,	PUNCT
dti-1378	155	97	q211	q211	PROPN
dti-1378	155	98	,	,	PUNCT
dti-1378	155	99	r212	r212	PROPN
dti-1378	155	100	,	,	PUNCT
dti-1378	155	101	e214	e214	PROPN
dti-1378	155	102	,	,	PUNCT
dti-1378	155	103	k217	k217	PROPN
dti-1378	155	104	,	,	PUNCT
dti-1378	155	105	w218	w218	PROPN
dti-1378	155	106	,	,	PUNCT
dti-1378	155	107	q220	q220	PROPN
dti-1378	155	108	,	,	PUNCT
dti-1378	155	109	c221	c221	PROPN
dti-1378	155	110	,	,	PUNCT
dti-1378	155	111	f222	f222	PROPN
dti-1378	155	112	,	,	PUNCT
dti-1378	155	113	n223	n223	PROPN
dti-1378	155	114	the	the	DET
dti-1378	155	115	beta	beta	NOUN
dti-1378	155	116	/	/	SYM
dti-1378	155	117	gamma	gamma	NOUN
dti-1378	155	118	complex	complex	NOUN
dti-1378	155	119	can	can	AUX
dti-1378	155	120	also	also	ADV
dti-1378	155	121	stimulate	stimulate	VERB
dti-1378	155	122	and	and	CCONJ
dti-1378	155	123	inhibit	inhibit	VERB
dti-1378	155	124	the	the	DET
dti-1378	155	125	adenylyl	adenylyl	NOUN
dti-1378	155	126	cyclase	cyclase	NOUN
dti-1378	155	127	activity	activity	NOUN
dti-1378	155	128	,	,	PUNCT
dti-1378	155	129	but	but	CCONJ
dti-1378	155	130	no	no	DET
dti-1378	155	131	model	model	NOUN
dti-1378	155	132	of	of	ADP
dti-1378	155	133	its	its	PRON
dti-1378	155	134	function	function	NOUN
dti-1378	155	135	had	have	AUX
dti-1378	155	136	been	be	AUX
dti-1378	155	137	established	establish	VERB
dti-1378	155	138	goloco	goloco	ADJ
dti-1378	155	139	binding	bind	VERB
dti-1378	155	140	site	site	NOUN
dti-1378	155	141	a47	a47	NOUN
dti-1378	155	142	,	,	PUNCT
dti-1378	155	143	g48	g48	NOUN
dti-1378	155	144	,	,	PUNCT
dti-1378	155	145	e49	e49	ADV
dti-1378	155	146	,	,	PUNCT
dti-1378	155	147	d77	d77	NOUN
dti-1378	155	148	,	,	PUNCT
dti-1378	155	149	k81	k81	PROPN
dti-1378	155	150	,	,	PUNCT
dti-1378	155	151	d85	d85	PROPN
dti-1378	155	152	,	,	PUNCT
dti-1378	155	153	c88	c88	NOUN
dti-1378	155	154	,	,	PUNCT
dti-1378	155	155	a91	a91	NOUN
dti-1378	155	156	,	,	PUNCT
dti-1378	155	157	g92	g92	PROPN
dti-1378	155	158	,	,	PUNCT
dti-1378	155	159	r112	r112	PROPN
dti-1378	155	160	,	,	PUNCT
dti-1378	155	161	i115	i115	PROPN
dti-1378	155	162	,	,	PUNCT
dti-1378	155	163	i156	i156	PROPN
dti-1378	155	164	,	,	PUNCT
dti-1378	155	165	r185	r185	PROPN
dti-1378	155	166	,	,	PUNCT
dti-1378	155	167	g210	g210	PROPN
dti-1378	155	168	,	,	PUNCT
dti-1378	155	169	w218	w218	PROPN
dti-1378	155	170	,	,	PUNCT
dti-1378	155	171	f222	f222	PROPN
dti-1378	155	172	it	it	PRON
dti-1378	155	173	binds	bind	VERB
dti-1378	155	174	gαi	gαi	PROPN
dti-1378	155	175	/	/	SYM
dti-1378	155	176	o	o	NOUN
dti-1378	155	177	/	/	SYM
dti-1378	155	178	gdp	gdp	NOUN
dti-1378	155	179	complex	complex	NOUN
dti-1378	155	180	and	and	CCONJ
dti-1378	155	181	prevents	prevent	VERB
dti-1378	155	182	the	the	DET
dti-1378	155	183	spontaneous	spontaneous	ADJ
dti-1378	155	184	release	release	NOUN
dti-1378	155	185	of	of	ADP
dti-1378	155	186	gdp	gdp	NOUN
dti-1378	155	187	by	by	ADP
dti-1378	155	188	gα	gα	NOUN
dti-1378	155	189	,	,	PUNCT
dti-1378	155	190	thus	thus	ADV
dti-1378	155	191	acting	act	VERB
dti-1378	155	192	as	as	ADP
dti-1378	155	193	a	a	DET
dti-1378	155	194	guanine	guanine	NOUN
dti-1378	155	195	nucleotide	nucleotide	NOUN
dti-1378	155	196	dissociation	dissociation	NOUN
dti-1378	155	197	inhibitor	inhibitor	NOUN
dti-1378	155	198	(	(	PUNCT
dti-1378	155	199	gdi	gdi	PROPN
dti-1378	155	200	)	)	PUNCT
dti-1378	155	201	putative	putative	ADJ
dti-1378	155	202	receptor	receptor	NOUN
dti-1378	155	203	binding	bind	VERB
dti-1378	155	204	site	site	NOUN
dti-1378	155	205	h342	h342	PROPN
dti-1378	155	206	,	,	PUNCT
dti-1378	155	207	y343	y343	PROPN
dti-1378	155	208	,	,	PUNCT
dti-1378	155	209	c344	c344	PROPN
dti-1378	155	210	,	,	PUNCT
dti-1378	155	211	y345	y345	PROPN
dti-1378	155	212	,	,	PUNCT
dti-1378	155	213	p346	p346	PROPN
dti-1378	155	214	,	,	PUNCT
dti-1378	155	215	h347	h347	PROPN
dti-1378	155	216	,	,	PUNCT
dti-1378	155	217	l348	l348	PROPN
dti-1378	155	218	,	,	PUNCT
dti-1378	155	219	t349	t349	PROPN
dti-1378	155	220	,	,	PUNCT
dti-1378	155	221	c350	c350	PROPN
dti-1378	155	222	,	,	PUNCT
dti-1378	155	223	a351	a351	PROPN
dti-1378	155	224	,	,	PUNCT
dti-1378	155	225	v352	v352	PROPN
dti-1378	155	226	,	,	PUNCT
dti-1378	155	227	d353	d353	PROPN
dti-1378	155	228	,	,	PUNCT
dti-1378	155	229	e355	e355	PROPN
dti-1378	155	230	,	,	PUNCT
dti-1378	155	231	n356	n356	NUM
dti-1378	155	232	,	,	PUNCT
dti-1378	155	233	i357	i357	PROPN
dti-1378	155	234	,	,	PUNCT
dti-1378	155	235	r358	r358	PRON
dti-1378	155	236	binds	bind	VERB
dti-1378	155	237	the	the	DET
dti-1378	155	238	protein	protein	NOUN
dti-1378	155	239	to	to	ADP
dti-1378	155	240	the	the	DET
dti-1378	155	241	serotonin	serotonin	NOUN
dti-1378	155	242	receptor	receptor	NOUN
dti-1378	155	243	(	(	PUNCT
dti-1378	155	244	smp_126730	smp_126730	NUM
dti-1378	155	245	)	)	PUNCT
dti-1378	155	246	switch	switch	NOUN
dti-1378	155	247	i	i	PRON
dti-1378	155	248	region	region	NOUN
dti-1378	155	249	r183	r183	PROPN
dti-1378	155	250	,	,	PUNCT
dti-1378	155	251	c184	c184	PROPN
dti-1378	155	252	,	,	PUNCT
dti-1378	155	253	r185	r185	PROPN
dti-1378	155	254	,	,	PUNCT
dti-1378	155	255	v186	v186	NUM
dti-1378	155	256	,	,	PUNCT
dti-1378	155	257	l187	l187	PROPN
dti-1378	155	258	,	,	PUNCT
dti-1378	155	259	t188	t188	NUM
dti-1378	155	260	,	,	PUNCT
dti-1378	155	261	s189	s189	PROPN
dti-1378	155	262	,	,	PUNCT
dti-1378	155	263	g190	g190	PROPN
dti-1378	155	264	,	,	PUNCT
dti-1378	155	265	i191	i191	NUM
dti-1378	155	266	molecular	molecular	ADJ
dti-1378	155	267	switches	switch	NOUN
dti-1378	155	268	(	(	PUNCT
dti-1378	155	269	called	call	VERB
dti-1378	155	270	the	the	DET
dti-1378	155	271	effector	effector	NOUN
dti-1378	155	272	loop	loop	PROPN
dti-1378	155	273	)	)	PUNCT
dti-1378	155	274	switch	switch	NOUN
dti-1378	155	275	ii	ii	PROPN
dti-1378	155	276	region	region	NOUN
dti-1378	155	277	v208	v208	PROPN
dti-1378	155	278	,	,	PUNCT
dti-1378	155	279	g209	g209	PROPN
dti-1378	155	280	,	,	PUNCT
dti-1378	155	281	g210	g210	PROPN
dti-1378	155	282	,	,	PUNCT
dti-1378	155	283	q211	q211	PROPN
dti-1378	155	284	,	,	PUNCT
dti-1378	155	285	r212	r212	PROPN
dti-1378	155	286	,	,	PUNCT
dti-1378	155	287	e213	e213	PROPN
dti-1378	155	288	,	,	PUNCT
dti-1378	155	289	e214	e214	PROPN
dti-1378	155	290	,	,	PUNCT
dti-1378	155	291	r215	r215	PROPN
dti-1378	155	292	,	,	PUNCT
dti-1378	155	293	r216	r216	NUM
dti-1378	155	294	,	,	PUNCT
dti-1378	155	295	k217	k217	PROPN
dti-1378	155	296	,	,	PUNCT
dti-1378	155	297	w218	w218	PROPN
dti-1378	155	298	,	,	PUNCT
dti-1378	155	299	i219	i219	PROPN
dti-1378	155	300	,	,	PUNCT
dti-1378	155	301	q220	q220	PROPN
dti-1378	155	302	,	,	PUNCT
dti-1378	155	303	c221	c221	PROPN
dti-1378	155	304	,	,	PUNCT
dti-1378	155	305	f222	f222	PROPN
dti-1378	155	306	,	,	PUNCT
dti-1378	155	307	n223	n223	PROPN
dti-1378	155	308	,	,	PUNCT
dti-1378	155	309	d224	d224	PROPN
dti-1378	155	310	molecular	molecular	ADJ
dti-1378	155	311	switches	switch	NOUN
dti-1378	155	312	g1	g1	PROPN
dti-1378	155	313	box	box	NOUN
dti-1378	155	314	motif	motif	NOUN
dti-1378	155	315	g46	g46	NOUN
dti-1378	155	316	,	,	PUNCT
dti-1378	155	317	a47	a47	NOUN
dti-1378	155	318	,	,	PUNCT
dti-1378	155	319	g48	g48	NOUN
dti-1378	155	320	,	,	PUNCT
dti-1378	155	321	e49	e49	ADJ
dti-1378	155	322	,	,	PUNCT
dti-1378	155	323	s50	s50	NOUN
dti-1378	155	324	,	,	PUNCT
dti-1378	155	325	g51	g51	ADJ
dti-1378	155	326	,	,	PUNCT
dti-1378	155	327	k52	k52	NOUN
dti-1378	155	328	,	,	PUNCT
dti-1378	155	329	s53	s53	ADJ
dti-1378	155	330	gtp	gtp	NOUN
dti-1378	155	331	binding	bind	VERB
dti-1378	155	332	signature	signature	NOUN
dti-1378	155	333	g2	g2	PROPN
dti-1378	155	334	box	box	NOUN
dti-1378	155	335	motif	motif	NOUN
dti-1378	155	336	t188	t188	PRON
dti-1378	155	337	involved	involve	VERB
dti-1378	155	338	in	in	ADP
dti-1378	155	339	mg2	mg2	PROPN
dti-1378	155	340	+	+	PROPN
dti-1378	155	341	coordination	coordination	PROPN
dti-1378	155	342	g3	g3	PROPN
dti-1378	155	343	box	box	NOUN
dti-1378	155	344	motif	motif	NOUN
dti-1378	155	345	d207	d207	PROPN
dti-1378	155	346	,	,	PUNCT
dti-1378	155	347	v208	v208	NUM
dti-1378	155	348	,	,	PUNCT
dti-1378	155	349	g209	g209	PROPN
dti-1378	155	350	,	,	PUNCT
dti-1378	155	351	g210	g210	PROPN
dti-1378	155	352	links	link	VERB
dti-1378	155	353	the	the	DET
dti-1378	155	354	subsites	subsite	NOUN
dti-1378	155	355	for	for	ADP
dti-1378	155	356	binding	bind	VERB
dti-1378	155	357	of	of	ADP
dti-1378	155	358	mg2	mg2	PROPN
dti-1378	155	359	+	+	PROPN
dti-1378	155	360	and	and	CCONJ
dti-1378	155	361	the	the	DET
dti-1378	155	362	γ	γ	NOUN
dti-1378	155	363	phosphate	phosphate	NOUN
dti-1378	155	364	of	of	ADP
dti-1378	155	365	gtp	gtp	NOUN
dti-1378	155	366	(	(	PUNCT
dti-1378	155	367	gtp	gtp	NOUN
dti-1378	155	368	γphosphatebinding	γphosphatebinding	NOUN
dti-1378	155	369	site	site	NOUN
dti-1378	155	370	)	)	PUNCT
dti-1378	155	371	g4	g4	NOUN
dti-1378	155	372	box	box	NOUN
dti-1378	155	373	motif	motif	NOUN
dti-1378	155	374	n276	n276	PROPN
dti-1378	155	375	,	,	PUNCT
dti-1378	155	376	k277	k277	PROPN
dti-1378	155	377	,	,	PUNCT
dti-1378	155	378	q278	q278	PROPN
dti-1378	155	379	,	,	PUNCT
dti-1378	155	380	d279	d279	PROPN
dti-1378	155	381	recognizes	recognize	VERB
dti-1378	155	382	the	the	DET
dti-1378	155	383	guanine	guanine	NOUN
dti-1378	155	384	ring	ring	NOUN
dti-1378	155	385	g5	g5	PROPN
dti-1378	155	386	box	box	NOUN
dti-1378	155	387	motif	motif	NOUN
dti-1378	155	388	c350	c350	PROPN
dti-1378	155	389	,	,	PUNCT
dti-1378	155	390	a351	a351	PROPN
dti-1378	155	391	,	,	PUNCT
dti-1378	155	392	v352	v352	PRON
dti-1378	155	393	buttresses	buttress	VERB
dti-1378	155	394	the	the	DET
dti-1378	155	395	guanine	guanine	NOUN
dti-1378	155	396	base	base	NOUN
dti-1378	155	397	recognition	recognition	NOUN
dti-1378	155	398	site	site	NOUN
dti-1378	155	399	notes	note	VERB
dti-1378	155	400	:	:	PUNCT
dti-1378	155	401	in	in	ADP
dti-1378	155	402	the	the	DET
dti-1378	155	403	schistosoma	schistosoma	ADJ
dti-1378	155	404	mansoni	mansoni	ADJ
dti-1378	155	405	protein	protein	NOUN
dti-1378	155	406	smp_059340.1	smp_059340.1	PROPN
dti-1378	155	407	,	,	PUNCT
dti-1378	155	408	each	each	PRON
dti-1378	155	409	of	of	ADP
dti-1378	155	410	the	the	DET
dti-1378	155	411	residues	residue	NOUN
dti-1378	155	412	contributing	contribute	VERB
dti-1378	155	413	to	to	ADP
dti-1378	155	414	the	the	DET
dti-1378	155	415	function	function	NOUN
dti-1378	155	416	of	of	ADP
dti-1378	155	417	each	each	DET
dti-1378	155	418	domain	domain	NOUN
dti-1378	155	419	in	in	ADP
dti-1378	155	420	the	the	DET
dti-1378	155	421	complex	complex	ADJ
dti-1378	155	422	network	network	NOUN
dti-1378	155	423	is	be	AUX
dti-1378	155	424	presented	present	VERB
dti-1378	155	425	.	.	PUNCT
dti-1378	156	1	most	most	ADJ
dti-1378	156	2	domains	domain	NOUN
dti-1378	156	3	share	share	VERB
dti-1378	156	4	residues	residue	NOUN
dti-1378	156	5	with	with	ADP
dti-1378	156	6	each	each	DET
dti-1378	156	7	other	other	ADJ
dti-1378	156	8	making	make	VERB
dti-1378	156	9	the	the	DET
dti-1378	156	10	network	network	NOUN
dti-1378	156	11	very	very	ADV
dti-1378	156	12	complex	complex	ADJ
dti-1378	156	13	at	at	ADP
dti-1378	156	14	atomistic	atomistic	ADJ
dti-1378	156	15	level	level	NOUN
dti-1378	156	16	.	.	PUNCT
dti-1378	157	1	379350300250200150100501	379350300250200150100501	NUM
dti-1378	157	2	query	query	PROPN
dti-1378	157	3	seq	seq	PROPN
dti-1378	157	4	.	.	PUNCT
dti-1378	158	1	specific	specific	ADJ
dti-1378	158	2	hits	hit	NOUN
dti-1378	158	3	super	super	ADJ
dti-1378	158	4	families	family	NOUN
dti-1378	158	5	multi	multi	ADJ
dti-1378	158	6	-	-	ADJ
dti-1378	158	7	domains	domain	NOUN
dti-1378	158	8	g4	g4	NOUN
dti-1378	158	9	box	box	PROPN
dti-1378	158	10	g3	g3	PROPN
dti-1378	158	11	box	box	PROPN
dti-1378	158	12	g2	g2	PROPN
dti-1378	158	13	box	box	PROPN
dti-1378	158	14	g1	g1	PROPN
dti-1378	158	15	box	box	PROPN
dti-1378	158	16	goloco	goloco	PROPN
dti-1378	158	17	binding	bind	VERB
dti-1378	158	18	site	site	NOUN
dti-1378	158	19	adenylyi	adenylyi	NOUN
dti-1378	158	20	cyclase	cyclase	NOUN
dti-1378	158	21	interaction	interaction	NOUN
dti-1378	158	22	site	site	NOUN
dti-1378	158	23	beta	beta	PROPN
dti-1378	158	24	gamma	gamma	NOUN
dti-1378	158	25	complex	complex	ADJ
dti-1378	158	26	interaction	interaction	NOUN
dti-1378	158	27	site	site	NOUN
dti-1378	158	28	switch	switch	PROPN
dti-1378	158	29	ii	ii	PROPN
dti-1378	158	30	region	region	NOUN
dti-1378	158	31	switch	switch	NOUN
dti-1378	158	32	i	i	PROPN
dti-1378	158	33	region	region	PROPN
dti-1378	158	34	gtp	gtp	PROPN
dti-1378	158	35	/	/	SYM
dti-1378	158	36	mg2	mg2	PROPN
dti-1378	158	37	+	+	CCONJ
dti-1378	158	38	binding	bind	VERB
dti-1378	158	39	site	site	NOUN
dti-1378	158	40	g5	g5	PROPN
dti-1378	158	41	box	box	PROPN
dti-1378	158	42	putative	putative	ADJ
dti-1378	158	43	receptor	receptor	NOUN
dti-1378	158	44	binding	bind	VERB
dti-1378	158	45	site	site	NOUN
dti-1378	158	46	g	g	NOUN
dti-1378	158	47	-	-	PUNCT
dti-1378	158	48	alpha	alpha	NOUN
dti-1378	158	49	p	p	NOUN
dti-1378	158	50	-	-	PUNCT
dti-1378	158	51	loop_ntpase	loop_ntpase	NOUN
dti-1378	158	52	superfamily	superfamily	ADV
dti-1378	158	53	g_alpha	g_alpha	NOUN
dti-1378	158	54	figure	figure	NOUN
dti-1378	158	55	3	3	NUM
dti-1378	158	56	.	.	PUNCT
dti-1378	159	1	visualization	visualization	NOUN
dti-1378	159	2	of	of	ADP
dti-1378	159	3	the	the	DET
dti-1378	159	4	12	12	NUM
dti-1378	159	5	functional	functional	ADJ
dti-1378	159	6	domains	domain	NOUN
dti-1378	159	7	of	of	ADP
dti-1378	159	8	schistosoma	schistosoma	ADJ
dti-1378	159	9	mansoni	mansoni	ADJ
dti-1378	159	10	smp_059340.1	smp_059340.1	PROPN
dti-1378	159	11	protein	protein	NOUN
dti-1378	159	12	.	.	PUNCT
dti-1378	160	1	notes	note	NOUN
dti-1378	160	2	:	:	PUNCT
dti-1378	160	3	the	the	DET
dti-1378	160	4	conserved	conserved	ADJ
dti-1378	160	5	domain	domain	NOUN
dti-1378	160	6	search	search	NOUN
dti-1378	160	7	tool	tool	NOUN
dti-1378	160	8	(	(	PUNCT
dti-1378	160	9	cd	cd	NOUN
dti-1378	160	10	-	-	PUNCT
dti-1378	160	11	search	search	NOUN
dti-1378	160	12	http://www.ncbi.nlm.nih.gov/cdd/	http://www.ncbi.nlm.nih.gov/cdd/	PROPN
dti-1378	160	13	)	)	PUNCT
dti-1378	160	14	was	be	AUX
dti-1378	160	15	used	use	VERB
dti-1378	160	16	to	to	PART
dti-1378	160	17	determine	determine	VERB
dti-1378	160	18	functional	functional	ADJ
dti-1378	160	19	domains	domain	NOUN
dti-1378	160	20	in	in	ADP
dti-1378	160	21	smp_059340.1	smp_059340.1	PROPN
dti-1378	160	22	.	.	PUNCT
dti-1378	161	1	the	the	DET
dti-1378	161	2	position	position	NOUN
dti-1378	161	3	and	and	CCONJ
dti-1378	161	4	span	span	NOUN
dti-1378	161	5	of	of	ADP
dti-1378	161	6	each	each	DET
dti-1378	161	7	domain	domain	NOUN
dti-1378	161	8	unit	unit	NOUN
dti-1378	161	9	across	across	ADP
dti-1378	161	10	the	the	DET
dti-1378	161	11	protein	protein	NOUN
dti-1378	161	12	are	be	AUX
dti-1378	161	13	shown	show	VERB
dti-1378	161	14	.	.	PUNCT
dti-1378	162	1	the	the	DET
dti-1378	162	2	positioning	positioning	NOUN
dti-1378	162	3	indicates	indicate	VERB
dti-1378	162	4	interdomain	interdomain	ADJ
dti-1378	162	5	connections	connection	NOUN
dti-1378	162	6	in	in	ADP
dti-1378	162	7	a	a	DET
dti-1378	162	8	probable	probable	ADJ
dti-1378	162	9	complex	complex	ADJ
dti-1378	162	10	network	network	NOUN
dti-1378	162	11	.	.	PUNCT
dti-1378	163	1	the	the	DET
dti-1378	163	2	12	12	NUM
dti-1378	163	3	domain	domain	NOUN
dti-1378	163	4	units	unit	NOUN
dti-1378	163	5	regulate	regulate	VERB
dti-1378	163	6	the	the	DET
dti-1378	163	7	function	function	NOUN
dti-1378	163	8	of	of	ADP
dti-1378	163	9	the	the	DET
dti-1378	163	10	smp_059340.1	smp_059340.1	PROPN
dti-1378	163	11	protein	protein	NOUN
dti-1378	163	12	.	.	PUNCT
dti-1378	164	1	http://www.la-press.com	http://www.la-press.com	X
dti-1378	165	1	http://www.ncbi.nlm.nih.gov/cdd/	http://www.ncbi.nlm.nih.gov/cdd/	X
dti-1378	165	2	mbah	mbah	PROPN
dti-1378	165	3	et	et	PROPN
dti-1378	165	4	al	al	PROPN
dti-1378	165	5	48	48	NUM
dti-1378	165	6	drug	drug	NOUN
dti-1378	165	7	target	target	NOUN
dti-1378	165	8	insights	insight	NOUN
dti-1378	165	9	2012:6	2012:6	NUM
dti-1378	165	10	dom	dom	NOUN
dti-1378	165	11	coil	coil	NOUN
dti-1378	165	12	(	(	PUNCT
dti-1378	165	13	fig	fig	NOUN
dti-1378	165	14	.	.	PUNCT
dti-1378	166	1	5a	5a	NUM
dti-1378	166	2	)	)	PUNCT
dti-1378	166	3	.	.	PUNCT
dti-1378	167	1	further	further	ADJ
dti-1378	167	2	comparison	comparison	NOUN
dti-1378	167	3	between	between	ADP
dti-1378	167	4	the	the	DET
dti-1378	167	5	template	template	NOUN
dti-1378	167	6	and	and	CCONJ
dti-1378	167	7	smp_059340.1	smp_059340.1	PROPN
dti-1378	167	8	(	(	PUNCT
dti-1378	167	9	target	target	NOUN
dti-1378	167	10	)	)	PUNCT
dti-1378	167	11	using	use	VERB
dti-1378	167	12	structural	structural	ADJ
dti-1378	167	13	superposition	superposition	NOUN
dti-1378	167	14	helped	help	VERB
dti-1378	167	15	to	to	PART
dti-1378	167	16	establish	establish	VERB
dti-1378	167	17	the	the	DET
dti-1378	167	18	regions	region	NOUN
dti-1378	167	19	of	of	ADP
dti-1378	167	20	the	the	DET
dti-1378	167	21	model	model	NOUN
dti-1378	167	22	,	,	PUNCT
dti-1378	167	23	which	which	PRON
dti-1378	167	24	agree	agree	VERB
dti-1378	167	25	and	and	CCONJ
dti-1378	167	26	disagree	disagree	VERB
dti-1378	167	27	(	(	PUNCT
dti-1378	167	28	fig	fig	NOUN
dti-1378	167	29	.	.	PUNCT
dti-1378	168	1	5b	5b	NUM
dti-1378	168	2	)	)	PUNCT
dti-1378	168	3	.	.	PUNCT
dti-1378	169	1	as	as	ADP
dti-1378	169	2	with	with	ADP
dti-1378	169	3	every	every	DET
dti-1378	169	4	model	model	NOUN
dti-1378	169	5	,	,	PUNCT
dti-1378	169	6	the	the	DET
dti-1378	169	7	agree	agree	ADJ
dti-1378	169	8	regions	region	NOUN
dti-1378	169	9	are	be	AUX
dti-1378	169	10	trustworthy	trustworthy	ADJ
dti-1378	169	11	while	while	SCONJ
dti-1378	169	12	disagree	disagree	VERB
dti-1378	169	13	regions	region	NOUN
dti-1378	169	14	are	be	AUX
dti-1378	169	15	generally	generally	ADV
dti-1378	169	16	treated	treat	VERB
dti-1378	169	17	with	with	ADP
dti-1378	169	18	caution	caution	NOUN
dti-1378	169	19	when	when	SCONJ
dti-1378	169	20	making	make	VERB
dti-1378	169	21	biological	biological	ADJ
dti-1378	169	22	inferences.25	inferences.25	NOUN
dti-1378	169	23	we	we	PRON
dti-1378	169	24	further	far	ADV
dti-1378	169	25	evaluated	evaluate	VERB
dti-1378	169	26	the	the	DET
dti-1378	169	27	quality	quality	NOUN
dti-1378	169	28	of	of	ADP
dti-1378	169	29	the	the	DET
dti-1378	169	30	model	model	NOUN
dti-1378	169	31	using	use	VERB
dti-1378	169	32	the	the	DET
dti-1378	169	33	ramachandran	ramachandran	PROPN
dti-1378	169	34	plot	plot	NOUN
dti-1378	169	35	on	on	ADP
dti-1378	169	36	the	the	DET
dti-1378	169	37	web	web	NOUN
dti-1378	169	38	(	(	PUNCT
dti-1378	169	39	2.0)26	2.0)26	NUM
dti-1378	169	40	(	(	PUNCT
dti-1378	169	41	fig	fig	NOUN
dti-1378	169	42	.	.	PUNCT
dti-1378	170	1	6a	6a	NOUN
dti-1378	170	2	)	)	PUNCT
dti-1378	170	3	and	and	CCONJ
dti-1378	170	4	rampage	rampage	NOUN
dti-1378	170	5	server27	server27	NOUN
dti-1378	170	6	(	(	PUNCT
dti-1378	170	7	fig	fig	NOUN
dti-1378	170	8	.	.	PUNCT
dti-1378	170	9	6b	6b	NUM
dti-1378	170	10	)	)	PUNCT
dti-1378	170	11	.	.	PUNCT
dti-1378	171	1	the	the	DET
dti-1378	171	2	ramachandran	ramachandran	PROPN
dti-1378	171	3	plot	plot	NOUN
dti-1378	171	4	had	have	AUX
dti-1378	171	5	been	be	AUX
dti-1378	171	6	widely	widely	ADV
dti-1378	171	7	used	use	VERB
dti-1378	171	8	for	for	ADP
dti-1378	171	9	assessing	assess	VERB
dti-1378	171	10	the	the	DET
dti-1378	171	11	quality	quality	NOUN
dti-1378	171	12	of	of	ADP
dti-1378	171	13	predicted	predict	VERB
dti-1378	171	14	models	model	NOUN
dti-1378	171	15	based	base	VERB
dti-1378	171	16	on	on	ADP
dti-1378	171	17	the	the	DET
dti-1378	171	18	phi	phi	ADJ
dti-1378	171	19	-	-	PUNCT
dti-1378	171	20	psi	psi	NOUN
dti-1378	171	21	torsion	torsion	NOUN
dti-1378	171	22	angles	angle	NOUN
dti-1378	171	23	of	of	ADP
dti-1378	171	24	all	all	DET
dti-1378	171	25	the	the	DET
dti-1378	171	26	residues.25,26,28–30	residues.25,26,28–30	ADJ
dti-1378	171	27	the	the	DET
dti-1378	171	28	fully	fully	ADV
dti-1378	171	29	-	-	PUNCT
dti-1378	171	30	allowed	allow	VERB
dti-1378	171	31	and	and	CCONJ
dti-1378	171	32	additionally	additionally	ADV
dti-1378	171	33	-	-	PUNCT
dti-1378	171	34	allowed	allow	VERB
dti-1378	171	35	regions	region	NOUN
dti-1378	171	36	from	from	ADP
dti-1378	171	37	the	the	DET
dti-1378	171	38	ramachandran	ramachandran	PROPN
dti-1378	171	39	plot	plot	NOUN
dti-1378	171	40	on	on	ADP
dti-1378	171	41	the	the	DET
dti-1378	171	42	web	web	NOUN
dti-1378	171	43	(	(	PUNCT
dti-1378	171	44	2.0	2.0	NUM
dti-1378	171	45	)	)	PUNCT
dti-1378	171	46	,	,	PUNCT
dti-1378	171	47	together	together	ADV
dti-1378	171	48	,	,	PUNCT
dti-1378	171	49	are	be	AUX
dti-1378	171	50	equivalent	equivalent	ADJ
dti-1378	171	51	to	to	ADP
dti-1378	171	52	the	the	DET
dti-1378	171	53	favored	favor	VERB
dti-1378	171	54	(	(	PUNCT
dti-1378	171	55	core	core	NOUN
dti-1378	171	56	)	)	PUNCT
dti-1378	171	57	region	region	NOUN
dti-1378	171	58	of	of	ADP
dti-1378	171	59	the	the	DET
dti-1378	171	60	rampage	rampage	NOUN
dti-1378	171	61	server	server	NOUN
dti-1378	171	62	.	.	PUNCT
dti-1378	172	1	in	in	ADP
dti-1378	172	2	addition	addition	NOUN
dti-1378	172	3	,	,	PUNCT
dti-1378	172	4	the	the	DET
dti-1378	172	5	generously	generously	ADV
dti-1378	172	6	allowed	allow	VERB
dti-1378	172	7	region	region	NOUN
dti-1378	172	8	from	from	ADP
dti-1378	172	9	the	the	DET
dti-1378	172	10	ramachandran	ramachandran	PROPN
dti-1378	172	11	plot	plot	NOUN
dti-1378	172	12	on	on	ADP
dti-1378	172	13	the	the	DET
dti-1378	172	14	web	web	NOUN
dti-1378	172	15	(	(	PUNCT
dti-1378	172	16	2.0	2.0	NUM
dti-1378	172	17	)	)	PUNCT
dti-1378	172	18	is	be	AUX
dti-1378	172	19	equivalent	equivalent	ADJ
dti-1378	172	20	to	to	ADP
dti-1378	172	21	the	the	DET
dti-1378	172	22	allowed	allow	VERB
dti-1378	172	23	region	region	NOUN
dti-1378	172	24	from	from	ADP
dti-1378	172	25	the	the	DET
dti-1378	172	26	rampage	rampage	NOUN
dti-1378	172	27	server	server	NOUN
dti-1378	172	28	(	(	PUNCT
dti-1378	172	29	fig	fig	NOUN
dti-1378	172	30	.	.	PUNCT
dti-1378	173	1	6a	6a	NOUN
dti-1378	173	2	and	and	CCONJ
dti-1378	173	3	b	b	NOUN
dti-1378	173	4	)	)	PUNCT
dti-1378	173	5	.	.	PUNCT
dti-1378	174	1	the	the	DET
dti-1378	174	2	ramachandran	ramachandran	PROPN
dti-1378	174	3	plot	plot	NOUN
dti-1378	174	4	analysis	analysis	NOUN
dti-1378	174	5	indicates	indicate	VERB
dti-1378	174	6	that	that	SCONJ
dti-1378	174	7	95.72	95.72	NUM
dti-1378	174	8	%	%	NOUN
dti-1378	174	9	of	of	ADP
dti-1378	174	10	the	the	DET
dti-1378	174	11	model	model	NOUN
dti-1378	174	12	residues	residue	NOUN
dti-1378	174	13	(	(	PUNCT
dti-1378	174	14	76.56	76.56	NUM
dti-1378	174	15	%	%	NOUN
dti-1378	174	16	fully	fully	ADV
dti-1378	174	17	allowed	allow	VERB
dti-1378	174	18	+	+	CCONJ
dti-1378	174	19	19.16	19.16	NUM
dti-1378	174	20	%	%	NOUN
dti-1378	174	21	additionally	additionally	ADV
dti-1378	174	22	allowed	allow	VERB
dti-1378	174	23	)	)	PUNCT
dti-1378	174	24	are	be	AUX
dti-1378	174	25	located	locate	VERB
dti-1378	174	26	in	in	ADP
dti-1378	174	27	the	the	DET
dti-1378	174	28	core	core	NOUN
dti-1378	174	29	or	or	CCONJ
dti-1378	174	30	favored	favor	VERB
dti-1378	174	31	region	region	NOUN
dti-1378	174	32	,	,	PUNCT
dti-1378	174	33	2.99	2.99	NUM
dti-1378	174	34	%	%	NOUN
dti-1378	174	35	in	in	ADP
dti-1378	174	36	the	the	DET
dti-1378	174	37	allowed	allow	VERB
dti-1378	174	38	region	region	NOUN
dti-1378	174	39	and	and	CCONJ
dti-1378	174	40	1.2	1.2	NUM
dti-1378	174	41	%	%	NOUN
dti-1378	174	42	in	in	ADP
dti-1378	174	43	the	the	DET
dti-1378	174	44	outside	outside	ADJ
dti-1378	174	45	region	region	NOUN
dti-1378	174	46	,	,	PUNCT
dti-1378	174	47	also	also	ADV
dti-1378	174	48	known	know	VERB
dti-1378	174	49	as	as	ADP
dti-1378	174	50	the	the	DET
dti-1378	174	51	outlier	outlier	NOUN
dti-1378	174	52	or	or	CCONJ
dti-1378	174	53	high	high	ADJ
dti-1378	174	54	energy	energy	NOUN
dti-1378	174	55	region	region	NOUN
dti-1378	174	56	(	(	PUNCT
dti-1378	174	57	fig	fig	NOUN
dti-1378	174	58	.	.	PUNCT
dti-1378	175	1	6c	6c	NOUN
dti-1378	175	2	)	)	PUNCT
dti-1378	175	3	.	.	PUNCT
dti-1378	176	1	residues	residue	NOUN
dti-1378	176	2	in	in	ADP
dti-1378	176	3	the	the	DET
dti-1378	176	4	high	high	ADJ
dti-1378	176	5	energy	energy	NOUN
dti-1378	176	6	region	region	NOUN
dti-1378	176	7	are	be	AUX
dti-1378	176	8	considered	consider	VERB
dti-1378	176	9	unstable	unstable	ADJ
dti-1378	176	10	and	and	CCONJ
dti-1378	176	11	can	can	AUX
dti-1378	176	12	compromise	compromise	VERB
dti-1378	176	13	the	the	DET
dti-1378	176	14	quality	quality	NOUN
dti-1378	176	15	of	of	ADP
dti-1378	176	16	a	a	DET
dti-1378	176	17	modeled	model	VERB
dti-1378	176	18	structure.31	structure.31	NOUN
dti-1378	176	19	a	a	DET
dti-1378	176	20	good	good	ADJ
dti-1378	176	21	quality	quality	NOUN
dti-1378	176	22	model	model	NOUN
dti-1378	176	23	is	be	AUX
dti-1378	176	24	expected	expect	VERB
dti-1378	176	25	to	to	PART
dti-1378	176	26	have	have	VERB
dti-1378	176	27	over	over	ADP
dti-1378	176	28	90	90	NUM
dti-1378	176	29	%	%	NOUN
dti-1378	176	30	of	of	ADP
dti-1378	176	31	the	the	DET
dti-1378	176	32	residues	residue	NOUN
dti-1378	176	33	in	in	ADP
dti-1378	176	34	the	the	DET
dti-1378	176	35	core	core	NOUN
dti-1378	176	36	region.26,29,30	region.26,29,30	PROPN
dti-1378	176	37	this	this	PRON
dti-1378	176	38	indicates	indicate	VERB
dti-1378	176	39	that	that	SCONJ
dti-1378	176	40	the	the	DET
dti-1378	176	41	smp_059340.1	smp_059340.1	PROPN
dti-1378	176	42	predicted	predict	VERB
dti-1378	176	43	model	model	NOUN
dti-1378	176	44	with	with	ADP
dti-1378	176	45	320	320	NUM
dti-1378	176	46	residues	residue	NOUN
dti-1378	176	47	in	in	ADP
dti-1378	176	48	the	the	DET
dti-1378	176	49	core	core	NOUN
dti-1378	176	50	region	region	NOUN
dti-1378	176	51	could	could	AUX
dti-1378	176	52	be	be	AUX
dti-1378	176	53	of	of	ADP
dti-1378	176	54	good	good	ADJ
dti-1378	176	55	quality	quality	NOUN
dti-1378	176	56	and	and	CCONJ
dti-1378	176	57	biologically	biologically	ADV
dti-1378	176	58	informative	informative	ADJ
dti-1378	176	59	.	.	PUNCT
dti-1378	177	1	table	table	NOUN
dti-1378	177	2	6	6	NUM
dti-1378	177	3	.	.	PUNCT
dti-1378	178	1	modeling	model	VERB
dti-1378	178	2	statistics	statistic	NOUN
dti-1378	178	3	of	of	ADP
dti-1378	178	4	smp_059340.1	smp_059340.1	PROPN
dti-1378	178	5	derived	derive	VERB
dti-1378	178	6	from	from	ADP
dti-1378	178	7	swissmodel	swissmodel	PROPN
dti-1378	178	8	server	server	PROPN
dti-1378	178	9	.	.	PUNCT
dti-1378	178	10	model	model	PROPN
dti-1378	178	11	information	information	NOUN
dti-1378	178	12	value	value	NOUN
dti-1378	178	13	modeled	model	VERB
dti-1378	178	14	residue	residue	NOUN
dti-1378	178	15	aligned	align	VERB
dti-1378	178	16	range	range	NOUN
dti-1378	178	17	39	39	NUM
dti-1378	178	18	to	to	PART
dti-1378	178	19	373	373	NUM
dti-1378	178	20	target	target	NOUN
dti-1378	178	21	sequence	sequence	NOUN
dti-1378	178	22	length	length	NOUN
dti-1378	178	23	378	378	NUM
dti-1378	178	24	template	template	NOUN
dti-1378	178	25	sequence	sequence	NOUN
dti-1378	178	26	length	length	NOUN
dti-1378	178	27	402	402	NUM
dti-1378	178	28	template	template	NOUN
dti-1378	178	29	1tl7c	1tl7c	NUM
dti-1378	178	30	(	(	PUNCT
dti-1378	178	31	2.80	2.80	NUM
dti-1378	178	32	å	å	NOUN
dti-1378	178	33	)	)	PUNCT
dti-1378	178	34	sequence	sequence	NOUN
dti-1378	178	35	identity	identity	NOUN
dti-1378	178	36	70.00	70.00	NUM
dti-1378	178	37	%	%	NOUN
dti-1378	178	38	target	target	NOUN
dti-1378	178	39	aligned	align	VERB
dti-1378	178	40	coverage	coverage	NOUN
dti-1378	178	41	88.00	88.00	NUM
dti-1378	178	42	%	%	NOUN
dti-1378	178	43	e	e	NOUN
dti-1378	178	44	value	value	NOUN
dti-1378	178	45	1.15e-133	1.15e-133	NUM
dti-1378	178	46	model	model	NOUN
dti-1378	178	47	quality	quality	PROPN
dti-1378	178	48	qmean	qmean	PROPN
dti-1378	178	49	score4	score4	PROPN
dti-1378	178	50	:	:	PUNCT
dti-1378	178	51	0.68	0.68	NUM
dti-1378	178	52	ligand	ligand	NOUN
dti-1378	178	53	(	(	PUNCT
dti-1378	178	54	s	s	NOUN
dti-1378	178	55	)	)	PUNCT
dti-1378	178	56	in	in	ADP
dti-1378	178	57	template	template	NOUN
dti-1378	178	58	gsp:1	gsp:1	PROPN
dti-1378	178	59	,	,	PUNCT
dti-1378	178	60	mg:1	mg:1	PROPN
dti-1378	178	61	notes	note	VERB
dti-1378	178	62	:	:	PUNCT
dti-1378	178	63	residues	residue	VERB
dti-1378	178	64	39	39	NUM
dti-1378	178	65	to	to	PART
dti-1378	178	66	373	373	NUM
dti-1378	178	67	of	of	ADP
dti-1378	178	68	smp_059340.1	smp_059340.1	PROPN
dti-1378	178	69	were	be	AUX
dti-1378	178	70	aligned	align	VERB
dti-1378	178	71	with	with	ADP
dti-1378	178	72	the	the	DET
dti-1378	178	73	template	template	NOUN
dti-1378	178	74	,	,	PUNCT
dti-1378	178	75	covering	cover	VERB
dti-1378	178	76	88.00	88.00	NUM
dti-1378	178	77	%	%	NOUN
dti-1378	178	78	of	of	ADP
dti-1378	178	79	its	its	PRON
dti-1378	178	80	entire	entire	ADJ
dti-1378	178	81	sequence	sequence	NOUN
dti-1378	178	82	length	length	NOUN
dti-1378	178	83	with	with	ADP
dti-1378	178	84	70.00	70.00	NUM
dti-1378	178	85	%	%	NOUN
dti-1378	178	86	sequence	sequence	NOUN
dti-1378	178	87	identity	identity	NOUN
dti-1378	178	88	.	.	PUNCT
dti-1378	179	1	a	a	DET
dti-1378	179	2	qmean	qmean	ADJ
dti-1378	179	3	score4	score4	NOUN
dti-1378	179	4	value	value	NOUN
dti-1378	179	5	of	of	ADP
dti-1378	179	6	0.68	0.68	NUM
dti-1378	179	7	suggests	suggest	VERB
dti-1378	179	8	the	the	DET
dti-1378	179	9	model	model	NOUN
dti-1378	179	10	could	could	AUX
dti-1378	179	11	be	be	AUX
dti-1378	179	12	of	of	ADP
dti-1378	179	13	good	good	ADJ
dti-1378	179	14	quality	quality	NOUN
dti-1378	179	15	and	and	CCONJ
dti-1378	179	16	can	can	AUX
dti-1378	179	17	be	be	AUX
dti-1378	179	18	biologically	biologically	ADV
dti-1378	179	19	informative	informative	ADJ
dti-1378	179	20	.	.	PUNCT
dti-1378	180	1	figure	figure	NOUN
dti-1378	180	2	5	5	NUM
dti-1378	180	3	.	.	PUNCT
dti-1378	180	4	sequence	sequence	NOUN
dti-1378	180	5	alignment	alignment	NOUN
dti-1378	180	6	and	and	CCONJ
dti-1378	180	7	structural	structural	ADJ
dti-1378	180	8	superposition	superposition	NOUN
dti-1378	180	9	of	of	ADP
dti-1378	180	10	smp_059340.1	smp_059340.1	PROPN
dti-1378	180	11	(	(	PUNCT
dti-1378	180	12	target	target	PROPN
dti-1378	180	13	)	)	PUNCT
dti-1378	180	14	and	and	CCONJ
dti-1378	180	15	the	the	DET
dti-1378	180	16	template	template	NOUN
dti-1378	180	17	.	.	PUNCT
dti-1378	181	1	(	(	PUNCT
dti-1378	181	2	a	a	X
dti-1378	181	3	)	)	PUNCT
dti-1378	181	4	alignment	alignment	NOUN
dti-1378	181	5	generated	generate	VERB
dti-1378	181	6	by	by	ADP
dti-1378	181	7	phyre2	phyre2	PROPN
dti-1378	181	8	server	server	PROPN
dti-1378	181	9	based	base	VERB
dti-1378	181	10	on	on	ADP
dti-1378	181	11	hmm	hmm	ADV
dti-1378	181	12	-	-	PUNCT
dti-1378	181	13	hmm	hmm	INTJ
dti-1378	181	14	matching	matching	NOUN
dti-1378	181	15	shows	show	VERB
dti-1378	181	16	that	that	SCONJ
dti-1378	181	17	the	the	DET
dti-1378	181	18	alpha	alpha	NOUN
dti-1378	181	19	helices	helix	NOUN
dti-1378	181	20	and	and	CCONJ
dti-1378	181	21	beta	beta	ADJ
dti-1378	181	22	strands	strand	NOUN
dti-1378	181	23	were	be	AUX
dti-1378	181	24	predicted	predict	VERB
dti-1378	181	25	with	with	ADP
dti-1378	181	26	approximate	approximate	ADJ
dti-1378	181	27	better	well	ADJ
dti-1378	181	28	confidence	confidence	NOUN
dti-1378	181	29	values	value	NOUN
dti-1378	181	30	than	than	ADP
dti-1378	181	31	the	the	DET
dti-1378	181	32	random	random	ADJ
dti-1378	181	33	coil	coil	NOUN
dti-1378	181	34	.	.	PUNCT
dti-1378	182	1	identical	identical	ADJ
dti-1378	182	2	residues	residue	NOUN
dti-1378	182	3	in	in	ADP
dti-1378	182	4	the	the	DET
dti-1378	182	5	alignment	alignment	NOUN
dti-1378	182	6	are	be	AUX
dti-1378	182	7	highlighted	highlight	VERB
dti-1378	182	8	with	with	ADP
dti-1378	182	9	a	a	DET
dti-1378	182	10	grey	grey	ADJ
dti-1378	182	11	background	background	NOUN
dti-1378	182	12	.	.	PUNCT
dti-1378	183	1	green	green	ADJ
dti-1378	183	2	helices	helix	NOUN
dti-1378	183	3	represent	represent	VERB
dti-1378	183	4	α	α	NOUN
dti-1378	183	5	-	-	PUNCT
dti-1378	183	6	helices	helix	NOUN
dti-1378	183	7	,	,	PUNCT
dti-1378	183	8	blue	blue	ADJ
dti-1378	183	9	arrows	arrow	NOUN
dti-1378	183	10	indicate	indicate	VERB
dti-1378	183	11	β	β	NOUN
dti-1378	183	12	-	-	NOUN
dti-1378	183	13	strands	strand	NOUN
dti-1378	183	14	and	and	CCONJ
dti-1378	183	15	faint	faint	ADJ
dti-1378	183	16	lines	line	NOUN
dti-1378	183	17	indicate	indicate	VERB
dti-1378	183	18	coil	coil	NOUN
dti-1378	183	19	.	.	PUNCT
dti-1378	184	1	the	the	DET
dti-1378	184	2	‘	'	PUNCT
dti-1378	184	3	ss	ss	NOUN
dti-1378	184	4	confidence	confidence	NOUN
dti-1378	184	5	’	'	PUNCT
dti-1378	184	6	line	line	NOUN
dti-1378	184	7	indicates	indicate	VERB
dti-1378	184	8	the	the	DET
dti-1378	184	9	confidence	confidence	NOUN
dti-1378	184	10	in	in	ADP
dti-1378	184	11	the	the	DET
dti-1378	184	12	prediction	prediction	NOUN
dti-1378	184	13	,	,	PUNCT
dti-1378	184	14	with	with	ADP
dti-1378	184	15	red	red	ADJ
dti-1378	184	16	being	be	AUX
dti-1378	184	17	high	high	ADJ
dti-1378	184	18	confidence	confidence	NOUN
dti-1378	184	19	and	and	CCONJ
dti-1378	184	20	blue	blue	ADJ
dti-1378	184	21	low	low	ADJ
dti-1378	184	22	confidence	confidence	NOUN
dti-1378	184	23	.	.	PUNCT
dti-1378	185	1	the	the	DET
dti-1378	185	2	orange	orange	ADJ
dti-1378	185	3	,	,	PUNCT
dti-1378	185	4	yellow	yellow	ADJ
dti-1378	185	5	and	and	CCONJ
dti-1378	185	6	green	green	PROPN
dti-1378	185	7	indicate	indicate	VERB
dti-1378	185	8	a	a	DET
dti-1378	185	9	weak	weak	ADJ
dti-1378	185	10	prediction	prediction	NOUN
dti-1378	185	11	.	.	PUNCT
dti-1378	186	1	(	(	PUNCT
dti-1378	186	2	b	b	X
dti-1378	186	3	)	)	PUNCT
dti-1378	186	4	comparison	comparison	NOUN
dti-1378	186	5	between	between	ADP
dti-1378	186	6	the	the	DET
dti-1378	186	7	template	template	NOUN
dti-1378	186	8	and	and	CCONJ
dti-1378	186	9	smp_059340.1	smp_059340.1	PROPN
dti-1378	186	10	(	(	PUNCT
dti-1378	186	11	target	target	NOUN
dti-1378	186	12	;	;	PUNCT
dti-1378	186	13	green	green	ADJ
dti-1378	186	14	)	)	PUNCT
dti-1378	186	15	using	use	VERB
dti-1378	186	16	structural	structural	ADJ
dti-1378	186	17	superposition	superposition	NOUN
dti-1378	186	18	to	to	PART
dti-1378	186	19	establish	establish	VERB
dti-1378	186	20	the	the	DET
dti-1378	186	21	regions	region	NOUN
dti-1378	186	22	of	of	ADP
dti-1378	186	23	the	the	DET
dti-1378	186	24	models	model	NOUN
dti-1378	186	25	,	,	PUNCT
dti-1378	186	26	which	which	PRON
dti-1378	186	27	agree	agree	VERB
dti-1378	186	28	and	and	CCONJ
dti-1378	186	29	disagree	disagree	VERB
dti-1378	186	30	.	.	PUNCT
dti-1378	187	1	the	the	DET
dti-1378	187	2	agree	agree	ADJ
dti-1378	187	3	regions	region	NOUN
dti-1378	187	4	are	be	AUX
dti-1378	187	5	trustworthy	trustworthy	ADJ
dti-1378	187	6	while	while	SCONJ
dti-1378	187	7	disagree	disagree	VERB
dti-1378	187	8	regions	region	NOUN
dti-1378	187	9	are	be	AUX
dti-1378	187	10	generally	generally	ADV
dti-1378	187	11	treated	treat	VERB
dti-1378	187	12	with	with	ADP
dti-1378	187	13	caution	caution	NOUN
dti-1378	187	14	when	when	SCONJ
dti-1378	187	15	making	make	VERB
dti-1378	187	16	biological	biological	ADJ
dti-1378	187	17	inference	inference	NOUN
dti-1378	187	18	.	.	PUNCT
dti-1378	188	1	figure	figure	NOUN
dti-1378	188	2	4	4	NUM
dti-1378	188	3	.	.	PUNCT
dti-1378	189	1	visualization	visualization	NOUN
dti-1378	189	2	of	of	ADP
dti-1378	189	3	the	the	DET
dti-1378	189	4	confidence	confidence	NOUN
dti-1378	189	5	level	level	NOUN
dti-1378	189	6	of	of	ADP
dti-1378	189	7	the	the	DET
dti-1378	189	8	modeled	model	VERB
dti-1378	189	9	residues	residue	NOUN
dti-1378	189	10	and	and	CCONJ
dti-1378	189	11	the	the	DET
dti-1378	189	12	error	error	NOUN
dti-1378	189	13	regions	region	NOUN
dti-1378	189	14	in	in	ADP
dti-1378	189	15	the	the	DET
dti-1378	189	16	3d	3d	NUM
dti-1378	189	17	modeled	model	VERB
dti-1378	189	18	structure	structure	NOUN
dti-1378	189	19	of	of	ADP
dti-1378	189	20	smp_059340.1	smp_059340.1	PROPN
dti-1378	189	21	.	.	PUNCT
dti-1378	190	1	(	(	PUNCT
dti-1378	190	2	a	a	X
dti-1378	190	3	)	)	PUNCT
dti-1378	190	4	the	the	DET
dti-1378	190	5	3d	3d	NUM
dti-1378	190	6	modeled	model	VERB
dti-1378	190	7	structure	structure	NOUN
dti-1378	190	8	of	of	ADP
dti-1378	190	9	smp_059340.1	smp_059340.1	PROPN
dti-1378	190	10	using	use	VERB
dti-1378	190	11	1tl7c	1tl7c	NUM
dti-1378	190	12	(	(	PUNCT
dti-1378	190	13	chain	chain	NOUN
dti-1378	190	14	c	c	NOUN
dti-1378	190	15	)	)	PUNCT
dti-1378	190	16	as	as	ADP
dti-1378	190	17	template	template	NOUN
dti-1378	190	18	with	with	ADP
dti-1378	190	19	93	93	NUM
dti-1378	190	20	%	%	NOUN
dti-1378	190	21	of	of	ADP
dti-1378	190	22	the	the	DET
dti-1378	190	23	residues	residue	NOUN
dti-1378	190	24	modeled	model	VERB
dti-1378	190	25	at	at	ADP
dti-1378	190	26	.90	.90	NUM
dti-1378	190	27	%	%	NOUN
dti-1378	190	28	confidence	confidence	NOUN
dti-1378	190	29	level	level	NOUN
dti-1378	190	30	analyzed	analyze	VERB
dti-1378	190	31	with	with	ADP
dti-1378	190	32	phyre	phyre	PROPN
dti-1378	190	33	/	/	SYM
dti-1378	190	34	phyre2	phyre2	PROPN
dti-1378	190	35	server	server	NOUN
dti-1378	190	36	and	and	CCONJ
dti-1378	190	37	confidence	confidence	NOUN
dti-1378	190	38	level	level	NOUN
dti-1378	190	39	range	range	NOUN
dti-1378	190	40	from	from	ADP
dti-1378	190	41	red	red	ADJ
dti-1378	190	42	(	(	PUNCT
dti-1378	190	43	high	high	ADJ
dti-1378	190	44	)	)	PUNCT
dti-1378	190	45	to	to	PART
dti-1378	190	46	low	low	ADJ
dti-1378	190	47	(	(	PUNCT
dti-1378	190	48	blue	blue	ADJ
dti-1378	190	49	)	)	PUNCT
dti-1378	190	50	.	.	PUNCT
dti-1378	191	1	(	(	PUNCT
dti-1378	191	2	b	b	X
dti-1378	191	3	)	)	PUNCT
dti-1378	191	4	residues	residue	NOUN
dti-1378	191	5	with	with	ADP
dti-1378	191	6	high	high	ADJ
dti-1378	191	7	score	score	NOUN
dti-1378	191	8	(	(	PUNCT
dti-1378	191	9	good	good	ADJ
dti-1378	191	10	structure	structure	NOUN
dti-1378	191	11	,	,	PUNCT
dti-1378	191	12	highly	highly	ADV
dti-1378	191	13	conserved	conserved	ADJ
dti-1378	191	14	,	,	PUNCT
dti-1378	191	15	deeply	deeply	ADV
dti-1378	191	16	buried	bury	VERB
dti-1378	191	17	)	)	PUNCT
dti-1378	191	18	are	be	AUX
dti-1378	191	19	colored	color	VERB
dti-1378	191	20	blue	blue	ADJ
dti-1378	191	21	(	(	PUNCT
dti-1378	191	22	low	low	ADJ
dti-1378	191	23	b	b	NOUN
dti-1378	191	24	-	-	PUNCT
dti-1378	191	25	factor	factor	NOUN
dti-1378	191	26	)	)	PUNCT
dti-1378	191	27	while	while	SCONJ
dti-1378	191	28	residue	residue	NOUN
dti-1378	191	29	with	with	ADP
dti-1378	191	30	low	low	ADJ
dti-1378	191	31	scores	score	NOUN
dti-1378	191	32	(	(	PUNCT
dti-1378	191	33	poor	poor	ADJ
dti-1378	191	34	structure	structure	NOUN
dti-1378	191	35	,	,	PUNCT
dti-1378	191	36	variable	variable	NOUN
dti-1378	191	37	,	,	PUNCT
dti-1378	191	38	exposed	expose	VERB
dti-1378	191	39	)	)	PUNCT
dti-1378	191	40	are	be	AUX
dti-1378	191	41	colored	color	VERB
dti-1378	191	42	red	red	ADJ
dti-1378	191	43	(	(	PUNCT
dti-1378	191	44	high	high	ADJ
dti-1378	191	45	b	b	NOUN
dti-1378	191	46	-	-	PUNCT
dti-1378	191	47	factor	factor	NOUN
dti-1378	191	48	)	)	PUNCT
dti-1378	191	49	.	.	PUNCT
dti-1378	192	1	notes	note	VERB
dti-1378	192	2	:	:	PUNCT
dti-1378	192	3	the	the	DET
dti-1378	192	4	intermediate	intermediate	ADJ
dti-1378	192	5	values	value	NOUN
dti-1378	192	6	may	may	AUX
dti-1378	192	7	range	range	VERB
dti-1378	192	8	from	from	ADP
dti-1378	192	9	green	green	ADJ
dti-1378	192	10	to	to	PART
dti-1378	192	11	yellow	yellow	VERB
dti-1378	192	12	to	to	PART
dti-1378	192	13	orange	orange	VERB
dti-1378	192	14	.	.	PUNCT
dti-1378	193	1	this	this	PRON
dti-1378	193	2	indicates	indicate	VERB
dti-1378	193	3	that	that	SCONJ
dti-1378	193	4	the	the	DET
dti-1378	193	5	model	model	NOUN
dti-1378	193	6	has	have	VERB
dti-1378	193	7	problems	problem	NOUN
dti-1378	193	8	with	with	ADP
dti-1378	193	9	the	the	DET
dti-1378	193	10	loops	loop	NOUN
dti-1378	193	11	and	and	CCONJ
dti-1378	193	12	alpha	alpha	NOUN
dti-1378	193	13	helix	helix	NOUN
dti-1378	193	14	but	but	CCONJ
dti-1378	193	15	not	not	PART
dti-1378	193	16	affecting	affect	VERB
dti-1378	193	17	the	the	DET
dti-1378	193	18	beta	beta	ADJ
dti-1378	193	19	sheet	sheet	NOUN
dti-1378	193	20	structures	structure	NOUN
dti-1378	193	21	.	.	PUNCT
dti-1378	194	1	http://www.la-press.com	http://www.la-press.com	X
dti-1378	194	2	drug	drug	NOUN
dti-1378	194	3	target	target	NOUN
dti-1378	194	4	features	feature	NOUN
dti-1378	194	5	of	of	ADP
dti-1378	194	6	schistosoma	schistosoma	ADJ
dti-1378	194	7	adenylyl	adenylyl	NOUN
dti-1378	194	8	cyclase	cyclase	NOUN
dti-1378	194	9	activity	activity	NOUN
dti-1378	194	10	drug	drug	NOUN
dti-1378	194	11	target	target	NOUN
dti-1378	194	12	insights	insight	NOUN
dti-1378	194	13	2012:6	2012:6	NUM
dti-1378	194	14	49	49	NUM
dti-1378	194	15	the	the	DET
dti-1378	194	16	rasmol	rasmol	PROPN
dti-1378	194	17	tool	tool	NOUN
dti-1378	194	18	was	be	AUX
dti-1378	194	19	used	use	VERB
dti-1378	194	20	to	to	PART
dti-1378	194	21	visualize	visualize	VERB
dti-1378	194	22	the	the	DET
dti-1378	194	23	modeled	model	VERB
dti-1378	194	24	tertiary	tertiary	ADJ
dti-1378	194	25	structure	structure	NOUN
dti-1378	194	26	of	of	ADP
dti-1378	194	27	the	the	DET
dti-1378	194	28	smp_059340.1	smp_059340.1	PROPN
dti-1378	194	29	protein	protein	NOUN
dti-1378	194	30	.	.	PUNCT
dti-1378	195	1	the	the	DET
dti-1378	195	2	secondary	secondary	ADJ
dti-1378	195	3	structure	structure	NOUN
dti-1378	195	4	components	component	NOUN
dti-1378	195	5	are	be	AUX
dti-1378	195	6	composed	compose	VERB
dti-1378	195	7	of	of	ADP
dti-1378	195	8	20	20	NUM
dti-1378	195	9	helices	helix	NOUN
dti-1378	195	10	,	,	PUNCT
dti-1378	195	11	8	8	NUM
dti-1378	195	12	sheets	sheet	NOUN
dti-1378	195	13	,	,	PUNCT
dti-1378	195	14	35	35	NUM
dti-1378	195	15	turns	turn	NOUN
dti-1378	195	16	and	and	CCONJ
dti-1378	195	17	3158	3158	NUM
dti-1378	195	18	hydrogen	hydrogen	NOUN
dti-1378	195	19	bonds	bond	NOUN
dti-1378	195	20	.	.	PUNCT
dti-1378	196	1	the	the	DET
dti-1378	196	2	helices	helix	NOUN
dti-1378	196	3	are	be	AUX
dti-1378	196	4	represented	represent	VERB
dti-1378	196	5	in	in	ADP
dti-1378	196	6	red	red	ADJ
dti-1378	196	7	,	,	PUNCT
dti-1378	196	8	sheets	sheet	NOUN
dti-1378	196	9	in	in	ADP
dti-1378	196	10	yellow	yellow	NOUN
dti-1378	196	11	and	and	CCONJ
dti-1378	196	12	turns	turn	VERB
dti-1378	196	13	in	in	ADP
dti-1378	196	14	blue	blue	ADJ
dti-1378	196	15	.	.	PUNCT
dti-1378	197	1	the	the	DET
dti-1378	197	2	white	white	ADJ
dti-1378	197	3	or	or	CCONJ
dti-1378	197	4	grayish	grayish	ADJ
dti-1378	197	5	colored	colored	ADJ
dti-1378	197	6	regions	region	NOUN
dti-1378	197	7	near	near	ADP
dti-1378	197	8	the	the	DET
dti-1378	197	9	turns	turn	NOUN
dti-1378	197	10	are	be	AUX
dti-1378	197	11	other	other	ADJ
dti-1378	197	12	secondary	secondary	ADJ
dti-1378	197	13	structures	structure	NOUN
dti-1378	197	14	(	(	PUNCT
dti-1378	197	15	fig	fig	NOUN
dti-1378	197	16	.	.	PUNCT
dti-1378	198	1	7	7	NUM
dti-1378	198	2	)	)	PUNCT
dti-1378	198	3	.	.	PUNCT
dti-1378	199	1	gtp	gtp	PROPN
dti-1378	199	2	/	/	SYM
dti-1378	199	3	mg2	mg2	PROPN
dti-1378	199	4	+	+	NOUN
dti-1378	199	5	ion	ion	NOUN
dti-1378	199	6	binding	bind	VERB
dti-1378	199	7	site	site	NOUN
dti-1378	199	8	domain	domain	VERB
dti-1378	199	9	the	the	DET
dti-1378	199	10	distribution	distribution	NOUN
dti-1378	199	11	of	of	ADP
dti-1378	199	12	the	the	DET
dti-1378	199	13	gtp	gtp	PROPN
dti-1378	199	14	/	/	SYM
dti-1378	199	15	mg2	mg2	PROPN
dti-1378	199	16	+	+	NOUN
dti-1378	199	17	ion	ion	NOUN
dti-1378	199	18	complex	complex	ADJ
dti-1378	199	19	binding	bind	VERB
dti-1378	199	20	site	site	NOUN
dti-1378	199	21	residues	residue	NOUN
dti-1378	199	22	(	(	PUNCT
dti-1378	199	23	green	green	ADJ
dti-1378	199	24	)	)	PUNCT
dti-1378	199	25	indicates	indicate	VERB
dti-1378	199	26	that	that	SCONJ
dti-1378	199	27	they	they	PRON
dti-1378	199	28	are	be	AUX
dti-1378	199	29	located	locate	VERB
dti-1378	199	30	on	on	ADP
dti-1378	199	31	the	the	DET
dti-1378	199	32	loops	loop	NOUN
dti-1378	199	33	,	,	PUNCT
dti-1378	199	34	helices	helix	NOUN
dti-1378	199	35	and	and	CCONJ
dti-1378	199	36	the	the	DET
dti-1378	199	37	β	β	NOUN
dti-1378	199	38	sheets	sheet	NOUN
dti-1378	199	39	(	(	PUNCT
dti-1378	199	40	fig	fig	NOUN
dti-1378	199	41	.	.	PUNCT
dti-1378	199	42	8a	8a	NUM
dti-1378	199	43	)	)	PUNCT
dti-1378	199	44	.	.	PUNCT
dti-1378	200	1	on	on	ADP
dti-1378	200	2	the	the	DET
dti-1378	200	3	protein	protein	NOUN
dti-1378	200	4	folded	fold	VERB
dti-1378	200	5	structure	structure	NOUN
dti-1378	200	6	these	these	DET
dti-1378	200	7	residues	residue	NOUN
dti-1378	200	8	are	be	AUX
dti-1378	200	9	situated	situate	VERB
dti-1378	200	10	in	in	ADP
dti-1378	200	11	the	the	DET
dti-1378	200	12	active	active	ADJ
dti-1378	200	13	site	site	NOUN
dti-1378	200	14	(	(	PUNCT
dti-1378	200	15	fold	fold	ADJ
dti-1378	200	16	)	)	PUNCT
dti-1378	200	17	of	of	ADP
dti-1378	200	18	the	the	DET
dti-1378	200	19	protein	protein	NOUN
dti-1378	200	20	that	that	PRON
dti-1378	200	21	extends	extend	VERB
dti-1378	200	22	to	to	ADP
dti-1378	200	23	the	the	DET
dti-1378	200	24	outer	outer	ADJ
dti-1378	200	25	side	side	NOUN
dti-1378	200	26	,	,	PUNCT
dti-1378	200	27	through	through	ADP
dti-1378	200	28	a	a	DET
dti-1378	200	29	hollow	hollow	ADJ
dti-1378	200	30	cavity	cavity	NOUN
dti-1378	200	31	cutting	cut	VERB
dti-1378	200	32	across	across	ADP
dti-1378	200	33	the	the	DET
dti-1378	200	34	protein	protein	NOUN
dti-1378	200	35	internal	internal	ADJ
dti-1378	200	36	structure	structure	NOUN
dti-1378	200	37	(	(	PUNCT
dti-1378	200	38	fig	fig	NOUN
dti-1378	200	39	.	.	PUNCT
dti-1378	201	1	8b	8b	NUM
dti-1378	201	2	)	)	PUNCT
dti-1378	201	3	.	.	PUNCT
dti-1378	202	1	the	the	DET
dti-1378	202	2	gtp	gtp	PROPN
dti-1378	202	3	/	/	SYM
dti-1378	202	4	mg2	mg2	PROPN
dti-1378	202	5	+	+	NOUN
dti-1378	202	6	ion	ion	NOUN
dti-1378	202	7	binding	bind	VERB
dti-1378	202	8	site	site	NOUN
dti-1378	202	9	shares	share	VERB
dti-1378	202	10	four	four	NUM
dti-1378	202	11	common	common	ADJ
dti-1378	202	12	residues	residue	NOUN
dti-1378	202	13	with	with	ADP
dti-1378	202	14	the	the	DET
dti-1378	202	15	g1	g1	PROPN
dti-1378	202	16	box	box	NOUN
dti-1378	202	17	motif	motif	NOUN
dti-1378	202	18	at	at	ADP
dti-1378	202	19	gly46	gly46	PROPN
dti-1378	202	20	,	,	PUNCT
dti-1378	202	21	gly51	gly51	PROPN
dti-1378	202	22	,	,	PUNCT
dti-1378	202	23	lys52	lys52	NOUN
dti-1378	202	24	and	and	CCONJ
dti-1378	202	25	ser53	ser53	PROPN
dti-1378	202	26	(	(	PUNCT
dti-1378	202	27	table	table	NOUN
dti-1378	202	28	5	5	NUM
dti-1378	202	29	)	)	PUNCT
dti-1378	202	30	.	.	PUNCT
dti-1378	203	1	the	the	DET
dti-1378	203	2	gtp	gtp	PROPN
dti-1378	203	3	/	/	SYM
dti-1378	203	4	mg2	mg2	PROPN
dti-1378	203	5	+	+	NOUN
dti-1378	203	6	ion	ion	NOUN
dti-1378	203	7	binding	bind	VERB
dti-1378	203	8	site	site	NOUN
dti-1378	203	9	converges	converge	NOUN
dti-1378	203	10	at	at	ADP
dti-1378	203	11	two	two	NUM
dti-1378	203	12	plastic	plastic	ADJ
dti-1378	203	13	regions	region	NOUN
dti-1378	203	14	of	of	ADP
dti-1378	203	15	switch	switch	NOUN
dti-1378	203	16	i	i	PRON
dti-1378	203	17	(	(	PUNCT
dti-1378	203	18	g2	g2	PROPN
dti-1378	203	19	box	box	PROPN
dti-1378	203	20	motif	motif	PROPN
dti-1378	203	21	threonine	threonine	NOUN
dti-1378	203	22	(	(	PUNCT
dti-1378	203	23	thr)188	thr)188	VERB
dti-1378	203	24	)	)	PUNCT
dti-1378	203	25	and	and	CCONJ
dti-1378	203	26	switch	switch	VERB
dti-1378	203	27	ii	ii	PROPN
dti-1378	203	28	(	(	PUNCT
dti-1378	203	29	gly210	gly210	NOUN
dti-1378	203	30	;	;	PUNCT
dti-1378	203	31	table	table	NOUN
dti-1378	203	32	5	5	NUM
dti-1378	203	33	)	)	PUNCT
dti-1378	203	34	.	.	PUNCT
dti-1378	204	1	the	the	DET
dti-1378	204	2	gtp	gtp	PROPN
dti-1378	204	3	/	/	SYM
dti-1378	204	4	mg2	mg2	PROPN
dti-1378	204	5	+	+	NOUN
dti-1378	204	6	ion	ion	NOUN
dti-1378	204	7	binding	bind	VERB
dti-1378	204	8	site	site	NOUN
dti-1378	204	9	also	also	ADV
dti-1378	204	10	shares	share	VERB
dti-1378	204	11	some	some	DET
dti-1378	204	12	conserved	conserved	ADJ
dti-1378	204	13	residues	residue	NOUN
dti-1378	204	14	with	with	ADP
dti-1378	204	15	the	the	DET
dti-1378	204	16	g3	g3	PROPN
dti-1378	204	17	box	box	NOUN
dti-1378	204	18	motif	motif	NOUN
dti-1378	204	19	at	at	ADP
dti-1378	204	20	aspartate	aspartate	NOUN
dti-1378	204	21	(	(	PUNCT
dti-1378	204	22	asp)207	asp)207	NOUN
dti-1378	204	23	,	,	PUNCT
dti-1378	204	24	and	and	CCONJ
dti-1378	204	25	with	with	ADP
dti-1378	204	26	the	the	DET
dti-1378	204	27	g4	g4	NOUN
dti-1378	204	28	box	box	NOUN
dti-1378	204	29	motif	motif	NOUN
dti-1378	204	30	at	at	ADP
dti-1378	204	31	residue	residue	NOUN
dti-1378	204	32	asparagine	asparagine	NOUN
dti-1378	204	33	(	(	PUNCT
dti-1378	204	34	asn)276	asn)276	NOUN
dti-1378	204	35	,	,	PUNCT
dti-1378	204	36	lys277	lys277	NOUN
dti-1378	204	37	and	and	CCONJ
dti-1378	204	38	asp279	asp279	PROPN
dti-1378	204	39	(	(	PUNCT
dti-1378	204	40	table	table	NOUN
dti-1378	204	41	5	5	NUM
dti-1378	204	42	)	)	PUNCT
dti-1378	204	43	.	.	PUNCT
dti-1378	205	1	figure	figure	VERB
dti-1378	205	2	6	6	NUM
dti-1378	205	3	.	.	PUNCT
dti-1378	205	4	model	model	NOUN
dti-1378	205	5	quality	quality	NOUN
dti-1378	205	6	evaluation	evaluation	NOUN
dti-1378	205	7	using	use	VERB
dti-1378	205	8	ramachandran	ramachandran	PROPN
dti-1378	205	9	plot	plot	NOUN
dti-1378	205	10	.	.	PUNCT
dti-1378	206	1	(	(	PUNCT
dti-1378	206	2	a	a	X
dti-1378	206	3	)	)	PUNCT
dti-1378	206	4	ramachandran	ramachandran	PROPN
dti-1378	206	5	plot	plot	NOUN
dti-1378	206	6	based	base	VERB
dti-1378	206	7	on	on	ADP
dti-1378	206	8	ramachandran	ramachandran	PROPN
dti-1378	206	9	plot	plot	NOUN
dti-1378	206	10	on	on	ADP
dti-1378	206	11	the	the	DET
dti-1378	206	12	web	web	NOUN
dti-1378	206	13	(	(	PUNCT
dti-1378	206	14	2.0	2.0	NUM
dti-1378	206	15	)	)	PUNCT
dti-1378	206	16	server	server	NOUN
dti-1378	206	17	:	:	PUNCT
dti-1378	206	18	more	more	ADJ
dti-1378	206	19	of	of	ADP
dti-1378	206	20	the	the	DET
dti-1378	206	21	model	model	NOUN
dti-1378	206	22	residues	residue	NOUN
dti-1378	206	23	are	be	AUX
dti-1378	206	24	in	in	ADP
dti-1378	206	25	the	the	DET
dti-1378	206	26	fully	fully	ADV
dti-1378	206	27	allowed	allow	VERB
dti-1378	206	28	and	and	CCONJ
dti-1378	206	29	additional	additional	ADJ
dti-1378	206	30	allowed	allow	VERB
dti-1378	206	31	regions	region	NOUN
dti-1378	206	32	(	(	PUNCT
dti-1378	206	33	total	total	NOUN
dti-1378	206	34	320	320	NUM
dti-1378	206	35	residues	residue	NOUN
dti-1378	206	36	(	(	PUNCT
dti-1378	206	37	95.72	95.72	NUM
dti-1378	206	38	%	%	NOUN
dti-1378	206	39	)	)	PUNCT
dti-1378	206	40	)	)	PUNCT
dti-1378	206	41	with	with	ADP
dti-1378	206	42	very	very	ADV
dti-1378	206	43	few	few	ADJ
dti-1378	206	44	residues	residue	NOUN
dti-1378	206	45	in	in	ADP
dti-1378	206	46	the	the	DET
dti-1378	206	47	outside	outside	ADJ
dti-1378	206	48	region	region	NOUN
dti-1378	206	49	(	(	PUNCT
dti-1378	206	50	4	4	NUM
dti-1378	206	51	residues	residue	NOUN
dti-1378	206	52	(	(	PUNCT
dti-1378	206	53	1.2	1.2	NUM
dti-1378	206	54	%	%	NOUN
dti-1378	206	55	)	)	PUNCT
dti-1378	206	56	)	)	PUNCT
dti-1378	206	57	.	.	PUNCT
dti-1378	207	1	the	the	DET
dti-1378	207	2	95.72	95.72	NUM
dti-1378	207	3	%	%	NOUN
dti-1378	207	4	indicates	indicate	VERB
dti-1378	207	5	that	that	SCONJ
dti-1378	207	6	the	the	DET
dti-1378	207	7	model	model	NOUN
dti-1378	207	8	is	be	AUX
dti-1378	207	9	stable	stable	ADJ
dti-1378	207	10	and	and	CCONJ
dti-1378	207	11	expected	expect	VERB
dti-1378	207	12	to	to	PART
dti-1378	207	13	be	be	AUX
dti-1378	207	14	of	of	ADP
dti-1378	207	15	good	good	ADJ
dti-1378	207	16	quality	quality	NOUN
dti-1378	207	17	based	base	VERB
dti-1378	207	18	on	on	ADP
dti-1378	207	19	the	the	DET
dti-1378	207	20	phi	phi	NOUN
dti-1378	207	21	–	–	PUNCT
dti-1378	207	22	psi	psi	NOUN
dti-1378	207	23	torsion	torsion	NOUN
dti-1378	207	24	angles	angle	NOUN
dti-1378	207	25	of	of	ADP
dti-1378	207	26	all	all	DET
dti-1378	207	27	the	the	DET
dti-1378	207	28	residues	residue	NOUN
dti-1378	207	29	in	in	ADP
dti-1378	207	30	the	the	DET
dti-1378	207	31	model	model	NOUN
dti-1378	207	32	.	.	PUNCT
dti-1378	208	1	(	(	PUNCT
dti-1378	208	2	b	b	X
dti-1378	208	3	)	)	PUNCT
dti-1378	208	4	ramachandran	ramachandran	PROPN
dti-1378	208	5	plot	plot	NOUN
dti-1378	208	6	based	base	VERB
dti-1378	208	7	on	on	ADP
dti-1378	208	8	rampage	rampage	NOUN
dti-1378	208	9	server	server	NOUN
dti-1378	208	10	:	:	PUNCT
dti-1378	208	11	this	this	PRON
dti-1378	208	12	confirms	confirm	VERB
dti-1378	208	13	and	and	CCONJ
dti-1378	208	14	validates	validate	VERB
dti-1378	208	15	the	the	DET
dti-1378	208	16	ramachandran	ramachandran	PROPN
dti-1378	208	17	plot	plot	NOUN
dti-1378	208	18	on	on	ADP
dti-1378	208	19	the	the	DET
dti-1378	208	20	web	web	NOUN
dti-1378	208	21	(	(	PUNCT
dti-1378	208	22	2.0	2.0	NUM
dti-1378	208	23	)	)	PUNCT
dti-1378	208	24	server	server	NOUN
dti-1378	208	25	.	.	PUNCT
dti-1378	209	1	it	it	PRON
dti-1378	209	2	shows	show	VERB
dti-1378	209	3	more	more	ADJ
dti-1378	209	4	model	model	NOUN
dti-1378	209	5	residues	residue	NOUN
dti-1378	209	6	are	be	AUX
dti-1378	209	7	in	in	ADP
dti-1378	209	8	the	the	DET
dti-1378	209	9	favored	favor	VERB
dti-1378	209	10	region	region	NOUN
dti-1378	209	11	(	(	PUNCT
dti-1378	209	12	total	total	ADJ
dti-1378	209	13	316	316	NUM
dti-1378	209	14	residues	residue	NOUN
dti-1378	209	15	(	(	PUNCT
dti-1378	209	16	94.6	94.6	NUM
dti-1378	209	17	%	%	NOUN
dti-1378	209	18	)	)	PUNCT
dti-1378	209	19	)	)	PUNCT
dti-1378	209	20	with	with	ADP
dti-1378	209	21	very	very	ADV
dti-1378	209	22	few	few	ADJ
dti-1378	209	23	residues	residue	NOUN
dti-1378	209	24	in	in	ADP
dti-1378	209	25	the	the	DET
dti-1378	209	26	outlier	outlier	ADJ
dti-1378	209	27	region	region	NOUN
dti-1378	209	28	(	(	PUNCT
dti-1378	209	29	5	5	NUM
dti-1378	209	30	residues	residue	NOUN
dti-1378	209	31	(	(	PUNCT
dti-1378	209	32	1.5	1.5	NUM
dti-1378	209	33	%	%	NOUN
dti-1378	209	34	)	)	PUNCT
dti-1378	209	35	)	)	PUNCT
dti-1378	209	36	.	.	PUNCT
dti-1378	210	1	it	it	PRON
dti-1378	210	2	also	also	ADV
dti-1378	210	3	shows	show	VERB
dti-1378	210	4	that	that	SCONJ
dti-1378	210	5	pro	pro	ADJ
dti-1378	210	6	245	245	NUM
dti-1378	210	7	and	and	CCONJ
dti-1378	210	8	asn	asn	PROPN
dti-1378	210	9	338	338	NUM
dti-1378	210	10	residues	residue	NOUN
dti-1378	210	11	are	be	AUX
dti-1378	210	12	the	the	DET
dti-1378	210	13	non	non	ADJ
dti-1378	210	14	-	-	ADJ
dti-1378	210	15	glycyl	glycyl	ADJ
dti-1378	210	16	residues	residue	NOUN
dti-1378	210	17	in	in	ADP
dti-1378	210	18	the	the	DET
dti-1378	210	19	additional	additional	ADJ
dti-1378	210	20	allowed	allow	VERB
dti-1378	210	21	region	region	NOUN
dti-1378	210	22	(	(	PUNCT
dti-1378	210	23	aar	aar	NOUN
dti-1378	210	24	)	)	PUNCT
dti-1378	210	25	.	.	PUNCT
dti-1378	211	1	image	image	NOUN
dti-1378	211	2	(	(	PUNCT
dti-1378	211	3	c	c	NOUN
dti-1378	211	4	)	)	PUNCT
dti-1378	211	5	complete	complete	ADJ
dti-1378	211	6	ramachandran	ramachandran	PROPN
dti-1378	211	7	plot	plot	NOUN
dti-1378	211	8	analysis	analysis	NOUN
dti-1378	211	9	:	:	PUNCT
dti-1378	211	10	it	it	PRON
dti-1378	211	11	shows	show	VERB
dti-1378	211	12	the	the	DET
dti-1378	211	13	distribution	distribution	NOUN
dti-1378	211	14	of	of	ADP
dti-1378	211	15	the	the	DET
dti-1378	211	16	whole	whole	ADJ
dti-1378	211	17	model	model	NOUN
dti-1378	211	18	residues	residue	NOUN
dti-1378	211	19	into	into	ADP
dti-1378	211	20	various	various	ADJ
dti-1378	211	21	energy	energy	NOUN
dti-1378	211	22	regions	region	NOUN
dti-1378	211	23	and	and	CCONJ
dti-1378	211	24	on	on	ADP
dti-1378	211	25	the	the	DET
dti-1378	211	26	α	α	NOUN
dti-1378	211	27	-	-	NOUN
dti-1378	211	28	helix	helix	NOUN
dti-1378	211	29	,	,	PUNCT
dti-1378	211	30	β	β	X
dti-1378	211	31	-	-	ADJ
dti-1378	211	32	strand	strand	NOUN
dti-1378	211	33	or	or	CCONJ
dti-1378	211	34	coil	coil	NOUN
dti-1378	211	35	based	base	VERB
dti-1378	211	36	on	on	ADP
dti-1378	211	37	the	the	DET
dti-1378	211	38	phi	phi	NOUN
dti-1378	211	39	–	–	PUNCT
dti-1378	211	40	psi	psi	NOUN
dti-1378	211	41	torsion	torsion	NOUN
dti-1378	211	42	angles	angle	NOUN
dti-1378	211	43	of	of	ADP
dti-1378	211	44	all	all	DET
dti-1378	211	45	the	the	DET
dti-1378	211	46	residues	residue	NOUN
dti-1378	211	47	in	in	ADP
dti-1378	211	48	the	the	DET
dti-1378	211	49	model	model	NOUN
dti-1378	211	50	.	.	PUNCT
dti-1378	212	1	figure	figure	VERB
dti-1378	212	2	7	7	NUM
dti-1378	212	3	.	.	PUNCT
dti-1378	212	4	homology	homology	NOUN
dti-1378	212	5	model	model	NOUN
dti-1378	212	6	of	of	ADP
dti-1378	212	7	schistosoma	schistosoma	ADJ
dti-1378	212	8	mansoni	mansoni	ADJ
dti-1378	212	9	protein	protein	NOUN
dti-1378	212	10	smp_059340.1	smp_059340.1	PROPN
dti-1378	212	11	.	.	PUNCT
dti-1378	213	1	(	(	PUNCT
dti-1378	213	2	a	a	X
dti-1378	213	3	)	)	PUNCT
dti-1378	213	4	the	the	DET
dti-1378	213	5	model	model	NOUN
dti-1378	213	6	colored	color	VERB
dti-1378	213	7	in	in	ADP
dti-1378	213	8	rainbow	rainbow	NOUN
dti-1378	213	9	n	n	PROPN
dti-1378	213	10	→	→	SYM
dti-1378	213	11	c	c	NOUN
dti-1378	213	12	terminus	terminus	NOUN
dti-1378	213	13	.	.	PUNCT
dti-1378	214	1	(	(	PUNCT
dti-1378	214	2	b	b	X
dti-1378	214	3	)	)	PUNCT
dti-1378	214	4	rasmol	rasmol	PROPN
dti-1378	214	5	tool	tool	NOUN
dti-1378	214	6	visualization	visualization	NOUN
dti-1378	214	7	of	of	ADP
dti-1378	214	8	model	model	NOUN
dti-1378	214	9	.	.	PUNCT
dti-1378	215	1	notes	note	NOUN
dti-1378	215	2	:	:	PUNCT
dti-1378	215	3	the	the	DET
dti-1378	215	4	helices	helix	NOUN
dti-1378	215	5	are	be	AUX
dti-1378	215	6	represented	represent	VERB
dti-1378	215	7	in	in	ADP
dti-1378	215	8	red	red	ADJ
dti-1378	215	9	;	;	PUNCT
dti-1378	215	10	beta	beta	ADJ
dti-1378	215	11	sheets	sheet	NOUN
dti-1378	215	12	are	be	AUX
dti-1378	215	13	yellow	yellow	ADJ
dti-1378	215	14	and	and	CCONJ
dti-1378	215	15	turns	turn	NOUN
dti-1378	215	16	are	be	AUX
dti-1378	215	17	depicted	depict	VERB
dti-1378	215	18	in	in	ADP
dti-1378	215	19	blue	blue	ADJ
dti-1378	215	20	.	.	PUNCT
dti-1378	216	1	the	the	DET
dti-1378	216	2	white	white	ADJ
dti-1378	216	3	or	or	CCONJ
dti-1378	216	4	grayish	grayish	ADJ
dti-1378	216	5	colored	colored	ADJ
dti-1378	216	6	regions	region	NOUN
dti-1378	216	7	near	near	ADP
dti-1378	216	8	the	the	DET
dti-1378	216	9	turns	turn	NOUN
dti-1378	216	10	are	be	AUX
dti-1378	216	11	other	other	ADJ
dti-1378	216	12	secondary	secondary	ADJ
dti-1378	216	13	structures	structure	NOUN
dti-1378	216	14	.	.	PUNCT
dti-1378	217	1	the	the	DET
dti-1378	217	2	secondary	secondary	ADJ
dti-1378	217	3	structure	structure	NOUN
dti-1378	217	4	components	component	NOUN
dti-1378	217	5	are	be	AUX
dti-1378	217	6	composed	compose	VERB
dti-1378	217	7	of	of	ADP
dti-1378	217	8	20	20	NUM
dti-1378	217	9	helices	helix	NOUN
dti-1378	217	10	,	,	PUNCT
dti-1378	217	11	8	8	NUM
dti-1378	217	12	sheets	sheet	NOUN
dti-1378	217	13	,	,	PUNCT
dti-1378	217	14	35	35	NUM
dti-1378	217	15	turns	turn	NOUN
dti-1378	217	16	and	and	CCONJ
dti-1378	217	17	3158	3158	NUM
dti-1378	217	18	hydrogen	hydrogen	NOUN
dti-1378	217	19	bonds	bond	NOUN
dti-1378	217	20	.	.	PUNCT
dti-1378	218	1	http://www.la-press.com	http://www.la-press.com	X
dti-1378	218	2	mbah	mbah	PROPN
dti-1378	218	3	et	et	PROPN
dti-1378	218	4	al	al	PROPN
dti-1378	218	5	50	50	NUM
dti-1378	218	6	drug	drug	NOUN
dti-1378	218	7	target	target	NOUN
dti-1378	218	8	insights	insight	NOUN
dti-1378	218	9	2012:6	2012:6	NUM
dti-1378	218	10	adenylyl	adenylyl	NOUN
dti-1378	218	11	cyclase	cyclase	NOUN
dti-1378	218	12	interaction	interaction	NOUN
dti-1378	218	13	site	site	NOUN
dti-1378	218	14	domain	domain	VERB
dti-1378	218	15	the	the	DET
dti-1378	218	16	adenylyl	adenylyl	NOUN
dti-1378	218	17	cyclase	cyclase	NOUN
dti-1378	218	18	interaction	interaction	NOUN
dti-1378	218	19	site	site	NOUN
dti-1378	218	20	consists	consist	VERB
dti-1378	218	21	of	of	ADP
dti-1378	218	22	5	5	NUM
dti-1378	218	23	residues	residue	NOUN
dti-1378	218	24	made	make	VERB
dti-1378	218	25	up	up	ADP
dti-1378	218	26	of	of	ADP
dti-1378	218	27	ile191	ile191	PROPN
dti-1378	218	28	,	,	PUNCT
dti-1378	218	29	arg216	arg216	PROPN
dti-1378	218	30	,	,	PUNCT
dti-1378	218	31	ile219	ile219	PROPN
dti-1378	218	32	,	,	PUNCT
dti-1378	218	33	glutamine	glutamine	NOUN
dti-1378	218	34	(	(	PUNCT
dti-1378	218	35	gln)220	gln)220	VERB
dti-1378	218	36	,	,	PUNCT
dti-1378	218	37	and	and	CCONJ
dti-1378	218	38	asn223	asn223	PROPN
dti-1378	218	39	(	(	PUNCT
dti-1378	218	40	black	black	ADJ
dti-1378	218	41	;	;	PUNCT
dti-1378	218	42	fig	fig	NOUN
dti-1378	218	43	.	.	PUNCT
dti-1378	219	1	8a	8a	NUM
dti-1378	219	2	)	)	PUNCT
dti-1378	219	3	,	,	PUNCT
dti-1378	219	4	which	which	PRON
dti-1378	219	5	binds	bind	VERB
dti-1378	219	6	and	and	CCONJ
dti-1378	219	7	stimulates	stimulate	VERB
dti-1378	219	8	adenylyl	adenylyl	ADJ
dti-1378	219	9	cyclase	cyclase	NOUN
dti-1378	219	10	activities	activity	NOUN
dti-1378	219	11	.	.	PUNCT
dti-1378	220	1	the	the	DET
dti-1378	220	2	distribution	distribution	NOUN
dti-1378	220	3	of	of	ADP
dti-1378	220	4	the	the	DET
dti-1378	220	5	adenylyl	adenylyl	NOUN
dti-1378	220	6	cyclase	cyclase	NOUN
dti-1378	220	7	interaction	interaction	NOUN
dti-1378	220	8	site	site	NOUN
dti-1378	220	9	residues	residue	NOUN
dti-1378	220	10	(	(	PUNCT
dti-1378	220	11	black	black	NOUN
dti-1378	220	12	)	)	PUNCT
dti-1378	220	13	indicates	indicate	VERB
dti-1378	220	14	that	that	SCONJ
dti-1378	220	15	they	they	PRON
dti-1378	220	16	are	be	AUX
dti-1378	220	17	located	locate	VERB
dti-1378	220	18	on	on	ADP
dti-1378	220	19	the	the	DET
dti-1378	220	20	loops	loop	NOUN
dti-1378	220	21	and	and	CCONJ
dti-1378	220	22	helices	helix	NOUN
dti-1378	220	23	only	only	ADV
dti-1378	220	24	(	(	PUNCT
dti-1378	220	25	fig	fig	NOUN
dti-1378	220	26	.	.	PUNCT
dti-1378	220	27	8a	8a	NUM
dti-1378	220	28	)	)	PUNCT
dti-1378	220	29	.	.	PUNCT
dti-1378	221	1	on	on	ADP
dti-1378	221	2	the	the	DET
dti-1378	221	3	protein	protein	NOUN
dti-1378	221	4	folded	fold	VERB
dti-1378	221	5	structure	structure	NOUN
dti-1378	221	6	these	these	DET
dti-1378	221	7	residues	residue	NOUN
dti-1378	221	8	are	be	AUX
dti-1378	221	9	localized	localize	VERB
dti-1378	221	10	on	on	ADP
dti-1378	221	11	the	the	DET
dti-1378	221	12	surface	surface	NOUN
dti-1378	221	13	of	of	ADP
dti-1378	221	14	the	the	DET
dti-1378	221	15	protein	protein	NOUN
dti-1378	221	16	(	(	PUNCT
dti-1378	221	17	fig	fig	NOUN
dti-1378	221	18	.	.	PUNCT
dti-1378	222	1	8a	8a	NUM
dti-1378	222	2	)	)	PUNCT
dti-1378	222	3	.	.	PUNCT
dti-1378	223	1	this	this	DET
dti-1378	223	2	approximate	approximate	ADJ
dti-1378	223	3	surface	surface	NOUN
dti-1378	223	4	location	location	NOUN
dti-1378	223	5	might	might	AUX
dti-1378	223	6	be	be	AUX
dti-1378	223	7	a	a	DET
dti-1378	223	8	natural	natural	ADJ
dti-1378	223	9	structural	structural	ADJ
dti-1378	223	10	orientation	orientation	NOUN
dti-1378	223	11	to	to	PART
dti-1378	223	12	provide	provide	VERB
dti-1378	223	13	efficiency	efficiency	NOUN
dti-1378	223	14	in	in	ADP
dti-1378	223	15	recognition	recognition	NOUN
dti-1378	223	16	and	and	CCONJ
dti-1378	223	17	binding	binding	NOUN
dti-1378	223	18	of	of	ADP
dti-1378	223	19	the	the	DET
dti-1378	223	20	adenylyl	adenylyl	NOUN
dti-1378	223	21	cyclase	cyclase	NOUN
dti-1378	223	22	enzyme	enzyme	NOUN
dti-1378	223	23	,	,	PUNCT
dti-1378	223	24	leading	lead	VERB
dti-1378	223	25	to	to	ADP
dti-1378	223	26	stimulation	stimulation	NOUN
dti-1378	223	27	of	of	ADP
dti-1378	223	28	the	the	DET
dti-1378	223	29	adenylyl	adenylyl	NOUN
dti-1378	223	30	cyclase	cyclase	NOUN
dti-1378	223	31	pathway	pathway	NOUN
dti-1378	223	32	during	during	ADP
dti-1378	223	33	the	the	DET
dti-1378	223	34	various	various	ADJ
dti-1378	223	35	developmental	developmental	ADJ
dti-1378	223	36	phases	phase	NOUN
dti-1378	223	37	of	of	ADP
dti-1378	223	38	s.	s.	PROPN
dti-1378	223	39	mansoni	mansoni	PROPN
dti-1378	223	40	.	.	PUNCT
dti-1378	224	1	the	the	DET
dti-1378	224	2	adenylyl	adenylyl	NOUN
dti-1378	224	3	cyclase	cyclase	NOUN
dti-1378	224	4	interaction	interaction	NOUN
dti-1378	224	5	site	site	NOUN
dti-1378	224	6	shared	share	VERB
dti-1378	224	7	4	4	NUM
dti-1378	224	8	out	out	ADP
dti-1378	224	9	of	of	ADP
dti-1378	224	10	its	its	PRON
dti-1378	224	11	5	5	NUM
dti-1378	224	12	residues	residue	NOUN
dti-1378	224	13	(	(	PUNCT
dti-1378	224	14	arg216	arg216	PROPN
dti-1378	224	15	,	,	PUNCT
dti-1378	224	16	ile	ile	NOUN
dti-1378	224	17	219	219	NUM
dti-1378	224	18	,	,	PUNCT
dti-1378	224	19	gln220	gln220	NOUN
dti-1378	224	20	and	and	CCONJ
dti-1378	224	21	asn223	asn223	PROPN
dti-1378	224	22	)	)	PUNCT
dti-1378	224	23	with	with	ADP
dti-1378	224	24	the	the	DET
dti-1378	224	25	switch	switch	NOUN
dti-1378	224	26	ii	ii	PROPN
dti-1378	224	27	region	region	NOUN
dti-1378	224	28	and	and	CCONJ
dti-1378	224	29	three	three	NUM
dti-1378	224	30	residues	residue	NOUN
dti-1378	224	31	(	(	PUNCT
dti-1378	224	32	ile191	ile191	PROPN
dti-1378	224	33	,	,	PUNCT
dti-1378	224	34	gln220	gln220	NOUN
dti-1378	224	35	and	and	CCONJ
dti-1378	224	36	asn223	asn223	PROPN
dti-1378	224	37	)	)	PUNCT
dti-1378	224	38	with	with	ADP
dti-1378	224	39	the	the	DET
dti-1378	224	40	beta	beta	NOUN
dti-1378	224	41	-	-	PUNCT
dti-1378	224	42	gamma	gamma	NOUN
dti-1378	224	43	complex	complex	ADJ
dti-1378	224	44	binding	bind	VERB
dti-1378	224	45	site	site	NOUN
dti-1378	224	46	(	(	PUNCT
dti-1378	224	47	table	table	NOUN
dti-1378	224	48	5	5	NUM
dti-1378	224	49	)	)	PUNCT
dti-1378	224	50	.	.	PUNCT
dti-1378	225	1	this	this	DET
dti-1378	225	2	interaction	interaction	NOUN
dti-1378	225	3	indicates	indicate	VERB
dti-1378	225	4	that	that	SCONJ
dti-1378	225	5	the	the	DET
dti-1378	225	6	adenylyl	adenylyl	NOUN
dti-1378	225	7	cyclase	cyclase	NOUN
dti-1378	225	8	interaction	interaction	NOUN
dti-1378	225	9	site	site	NOUN
dti-1378	225	10	is	be	AUX
dti-1378	225	11	totally	totally	ADV
dti-1378	225	12	coupled	couple	VERB
dti-1378	225	13	to	to	ADP
dti-1378	225	14	the	the	DET
dti-1378	225	15	beta	beta	NOUN
dti-1378	225	16	-	-	PUNCT
dti-1378	225	17	gamma	gamma	NOUN
dti-1378	225	18	complex	complex	NOUN
dti-1378	225	19	,	,	PUNCT
dti-1378	225	20	and	and	CCONJ
dti-1378	225	21	that	that	SCONJ
dti-1378	225	22	it	it	PRON
dti-1378	225	23	is	be	AUX
dti-1378	225	24	almost	almost	ADV
dti-1378	225	25	completely	completely	ADV
dti-1378	225	26	embedded	embed	VERB
dti-1378	225	27	in	in	ADP
dti-1378	225	28	the	the	DET
dti-1378	225	29	switch	switch	NOUN
dti-1378	225	30	ii	ii	PROPN
dti-1378	225	31	region	region	NOUN
dti-1378	225	32	.	.	PUNCT
dti-1378	226	1	as	as	ADP
dti-1378	226	2	such	such	ADJ
dti-1378	226	3	,	,	PUNCT
dti-1378	226	4	the	the	DET
dti-1378	226	5	adenylyl	adenylyl	NOUN
dti-1378	226	6	cyclase	cyclase	NOUN
dti-1378	226	7	binding	bind	VERB
dti-1378	226	8	site	site	NOUN
dti-1378	226	9	might	might	AUX
dti-1378	226	10	be	be	AUX
dti-1378	226	11	contributing	contribute	VERB
dti-1378	226	12	to	to	ADP
dti-1378	226	13	the	the	DET
dti-1378	226	14	conformation	conformation	NOUN
dti-1378	226	15	changes	change	NOUN
dti-1378	226	16	that	that	PRON
dti-1378	226	17	occur	occur	VERB
dti-1378	226	18	during	during	ADP
dti-1378	226	19	functioning	function	VERB
dti-1378	226	20	of	of	ADP
dti-1378	226	21	the	the	DET
dti-1378	226	22	switch	switch	NOUN
dti-1378	226	23	ii	ii	PROPN
dti-1378	226	24	region	region	NOUN
dti-1378	226	25	.	.	PUNCT
dti-1378	227	1	beta	beta	NOUN
dti-1378	227	2	-	-	PUNCT
dti-1378	227	3	gamma	gamma	NOUN
dti-1378	227	4	complex	complex	ADJ
dti-1378	227	5	interaction	interaction	NOUN
dti-1378	227	6	site	site	NOUN
dti-1378	227	7	and	and	CCONJ
dti-1378	227	8	goloco	goloco	ADJ
dti-1378	227	9	binding	bind	VERB
dti-1378	227	10	site	site	NOUN
dti-1378	227	11	domains	domain	VERB
dti-1378	227	12	the	the	DET
dti-1378	227	13	beta	beta	NOUN
dti-1378	227	14	-	-	PUNCT
dti-1378	227	15	gamma	gamma	NOUN
dti-1378	227	16	residues	residue	NOUN
dti-1378	227	17	(	(	PUNCT
dti-1378	227	18	green	green	NOUN
dti-1378	227	19	)	)	PUNCT
dti-1378	227	20	are	be	AUX
dti-1378	227	21	located	locate	VERB
dti-1378	227	22	on	on	ADP
dti-1378	227	23	the	the	DET
dti-1378	227	24	helix	helix	NOUN
dti-1378	227	25	,	,	PUNCT
dti-1378	227	26	loop	loop	NOUN
dti-1378	227	27	and	and	CCONJ
dti-1378	227	28	β	β	NOUN
dti-1378	227	29	sheets	sheet	NOUN
dti-1378	227	30	,	,	PUNCT
dti-1378	227	31	and	and	CCONJ
dti-1378	227	32	they	they	PRON
dti-1378	227	33	share	share	VERB
dti-1378	227	34	common	common	ADJ
dti-1378	227	35	residues	residue	NOUN
dti-1378	227	36	(	(	PUNCT
dti-1378	227	37	gly210	gly210	NOUN
dti-1378	227	38	,	,	PUNCT
dti-1378	227	39	trp218	trp218	PROPN
dti-1378	227	40	and	and	CCONJ
dti-1378	227	41	phe222	phe222	PROPN
dti-1378	227	42	;	;	PUNCT
dti-1378	227	43	blue	blue	ADJ
dti-1378	227	44	)	)	PUNCT
dti-1378	227	45	with	with	ADP
dti-1378	227	46	the	the	DET
dti-1378	227	47	goloco	goloco	ADJ
dti-1378	227	48	binding	bind	VERB
dti-1378	227	49	site	site	NOUN
dti-1378	227	50	on	on	ADP
dti-1378	227	51	the	the	DET
dti-1378	227	52	loop	loop	NOUN
dti-1378	227	53	and	and	CCONJ
dti-1378	227	54	helix	helix	NOUN
dti-1378	227	55	(	(	PUNCT
dti-1378	227	56	fig	fig	NOUN
dti-1378	227	57	.	.	PUNCT
dti-1378	227	58	9a	9a	NOUN
dti-1378	227	59	)	)	PUNCT
dti-1378	227	60	.	.	PUNCT
dti-1378	228	1	within	within	ADP
dti-1378	228	2	the	the	DET
dti-1378	228	3	protein	protein	NOUN
dti-1378	228	4	folded	fold	VERB
dti-1378	228	5	structure	structure	NOUN
dti-1378	228	6	,	,	PUNCT
dti-1378	228	7	the	the	DET
dti-1378	228	8	beta	beta	NOUN
dti-1378	228	9	-	-	PUNCT
dti-1378	228	10	gamma	gamma	NOUN
dti-1378	228	11	complex	complex	ADJ
dti-1378	228	12	site	site	NOUN
dti-1378	228	13	(	(	PUNCT
dti-1378	228	14	green	green	NOUN
dti-1378	228	15	)	)	PUNCT
dti-1378	228	16	is	be	AUX
dti-1378	228	17	positioned	position	VERB
dti-1378	228	18	on	on	ADP
dti-1378	228	19	the	the	DET
dti-1378	228	20	surface	surface	NOUN
dti-1378	228	21	(	(	PUNCT
dti-1378	228	22	fig	fig	NOUN
dti-1378	228	23	.	.	PUNCT
dti-1378	229	1	9b	9b	NUM
dti-1378	229	2	)	)	PUNCT
dti-1378	229	3	,	,	PUNCT
dti-1378	229	4	in	in	ADP
dti-1378	229	5	close	close	ADJ
dti-1378	229	6	proximity	proximity	NOUN
dti-1378	229	7	to	to	ADP
dti-1378	229	8	the	the	DET
dti-1378	229	9	location	location	NOUN
dti-1378	229	10	of	of	ADP
dti-1378	229	11	the	the	DET
dti-1378	229	12	gtp	gtp	PROPN
dti-1378	229	13	/	/	SYM
dti-1378	229	14	mg2	mg2	PROPN
dti-1378	229	15	+	+	NOUN
dti-1378	229	16	ion	ion	NOUN
dti-1378	229	17	complex	complex	ADJ
dti-1378	229	18	binding	bind	VERB
dti-1378	229	19	site	site	NOUN
dti-1378	229	20	through	through	ADP
dti-1378	229	21	residue	residue	NOUN
dti-1378	229	22	gly210	gly210	NOUN
dti-1378	229	23	.	.	PUNCT
dti-1378	230	1	at	at	ADP
dti-1378	230	2	the	the	DET
dti-1378	230	3	adenylyl	adenylyl	NOUN
dti-1378	230	4	cyclase	cyclase	NOUN
dti-1378	230	5	interaction	interaction	NOUN
dti-1378	230	6	site	site	NOUN
dti-1378	230	7	the	the	DET
dti-1378	230	8	beta	beta	NOUN
dti-1378	230	9	-	-	PUNCT
dti-1378	230	10	gamma	gamma	NOUN
dti-1378	230	11	complex	complex	ADJ
dti-1378	230	12	site	site	NOUN
dti-1378	230	13	interconnect	interconnect	NOUN
dti-1378	230	14	at	at	ADP
dti-1378	230	15	residue	residue	NOUN
dti-1378	230	16	ile191	ile191	PROPN
dti-1378	230	17	,	,	PUNCT
dti-1378	230	18	gln220	gln220	NOUN
dti-1378	230	19	and	and	CCONJ
dti-1378	230	20	asn223	asn223	PROPN
dti-1378	230	21	,	,	PUNCT
dti-1378	230	22	while	while	SCONJ
dti-1378	230	23	at	at	ADP
dti-1378	230	24	the	the	DET
dti-1378	230	25	goloco	goloco	ADJ
dti-1378	230	26	binding	bind	VERB
dti-1378	230	27	site	site	NOUN
dti-1378	230	28	,	,	PUNCT
dti-1378	230	29	the	the	DET
dti-1378	230	30	beta	beta	NOUN
dti-1378	230	31	-	-	PUNCT
dti-1378	230	32	gamma	gamma	NOUN
dti-1378	230	33	complex	complex	ADJ
dti-1378	230	34	site	site	NOUN
dti-1378	230	35	shares	share	NOUN
dti-1378	230	36	residue	residue	NOUN
dti-1378	230	37	gly210	gly210	NOUN
dti-1378	230	38	,	,	PUNCT
dti-1378	230	39	trp218	trp218	PROPN
dti-1378	230	40	and	and	CCONJ
dti-1378	230	41	phe222	phe222	PROPN
dti-1378	230	42	shown	show	VERB
dti-1378	230	43	in	in	ADP
dti-1378	230	44	blue	blue	ADJ
dti-1378	230	45	(	(	PUNCT
dti-1378	230	46	fig	fig	NOUN
dti-1378	230	47	.	.	PUNCT
dti-1378	230	48	9b	9b	NUM
dti-1378	230	49	)	)	PUNCT
dti-1378	230	50	.	.	PUNCT
dti-1378	231	1	the	the	DET
dti-1378	231	2	goloco	goloco	ADJ
dti-1378	231	3	binding	bind	VERB
dti-1378	231	4	site	site	NOUN
dti-1378	231	5	(	(	PUNCT
dti-1378	231	6	black	black	NOUN
dti-1378	231	7	)	)	PUNCT
dti-1378	231	8	has	have	VERB
dti-1378	231	9	residues	residue	NOUN
dti-1378	231	10	located	locate	VERB
dti-1378	231	11	on	on	ADP
dti-1378	231	12	the	the	DET
dti-1378	231	13	helices	helix	NOUN
dti-1378	231	14	and	and	CCONJ
dti-1378	231	15	the	the	DET
dti-1378	231	16	loops	loop	NOUN
dti-1378	231	17	(	(	PUNCT
dti-1378	231	18	fig	fig	NOUN
dti-1378	231	19	.	.	PUNCT
dti-1378	231	20	9a	9a	NOUN
dti-1378	231	21	)	)	PUNCT
dti-1378	231	22	.	.	PUNCT
dti-1378	232	1	it	it	PRON
dti-1378	232	2	is	be	AUX
dti-1378	232	3	situated	situate	VERB
dti-1378	232	4	in	in	ADP
dti-1378	232	5	close	close	ADJ
dti-1378	232	6	proximity	proximity	NOUN
dti-1378	232	7	to	to	ADP
dti-1378	232	8	the	the	DET
dti-1378	232	9	location	location	NOUN
dti-1378	232	10	of	of	ADP
dti-1378	232	11	switch	switch	NOUN
dti-1378	232	12	i	i	PRON
dti-1378	232	13	,	,	PUNCT
dti-1378	232	14	switch	switch	VERB
dti-1378	232	15	ii	ii	PROPN
dti-1378	232	16	and	and	CCONJ
dti-1378	232	17	the	the	DET
dti-1378	232	18	beta	beta	NOUN
dti-1378	232	19	-	-	PUNCT
dti-1378	232	20	gamma	gamma	NOUN
dti-1378	232	21	binding	bind	VERB
dti-1378	232	22	site	site	NOUN
dti-1378	232	23	(	(	PUNCT
dti-1378	232	24	fig	fig	NOUN
dti-1378	232	25	.	.	PUNCT
dti-1378	233	1	9b	9b	NUM
dti-1378	233	2	)	)	PUNCT
dti-1378	233	3	,	,	PUNCT
dti-1378	233	4	where	where	SCONJ
dti-1378	233	5	it	it	PRON
dti-1378	233	6	can	can	AUX
dti-1378	233	7	influence	influence	VERB
dti-1378	233	8	their	their	PRON
dti-1378	233	9	activities	activity	NOUN
dti-1378	233	10	independently	independently	ADV
dti-1378	233	11	due	due	ADJ
dti-1378	233	12	their	their	PRON
dti-1378	233	13	common	common	ADJ
dti-1378	233	14	shared	share	VERB
dti-1378	233	15	residues	residue	NOUN
dti-1378	233	16	as	as	SCONJ
dti-1378	233	17	explained	explain	VERB
dti-1378	233	18	above	above	ADV
dti-1378	233	19	.	.	PUNCT
dti-1378	234	1	the	the	DET
dti-1378	234	2	goloco	goloco	ADJ
dti-1378	234	3	figure	figure	NOUN
dti-1378	234	4	8	8	NUM
dti-1378	234	5	.	.	PUNCT
dti-1378	235	1	the	the	DET
dti-1378	235	2	distribution	distribution	NOUN
dti-1378	235	3	of	of	ADP
dti-1378	235	4	gtp	gtp	PROPN
dti-1378	235	5	/	/	SYM
dti-1378	235	6	mg2	mg2	PROPN
dti-1378	235	7	+	+	NOUN
dti-1378	235	8	ion	ion	NOUN
dti-1378	235	9	complex	complex	ADJ
dti-1378	235	10	binding	bind	VERB
dti-1378	235	11	site	site	NOUN
dti-1378	235	12	an	an	DET
dti-1378	235	13	adenylyl	adenylyl	NOUN
dti-1378	235	14	cyclase	cyclase	NOUN
dti-1378	235	15	interaction	interaction	NOUN
dti-1378	235	16	site	site	NOUN
dti-1378	235	17	residues	residue	NOUN
dti-1378	235	18	on	on	ADP
dti-1378	235	19	the	the	DET
dti-1378	235	20	3	3	NUM
dti-1378	235	21	-	-	PUNCT
dti-1378	235	22	dimensional	dimensional	ADJ
dti-1378	235	23	structure	structure	NOUN
dti-1378	235	24	of	of	ADP
dti-1378	235	25	schistosoma	schistosoma	ADJ
dti-1378	235	26	mansoni	mansoni	ADJ
dti-1378	235	27	smp_059340.1	smp_059340.1	PROPN
dti-1378	235	28	.	.	PUNCT
dti-1378	236	1	(	(	PUNCT
dti-1378	236	2	a	a	X
dti-1378	236	3	)	)	PUNCT
dti-1378	236	4	the	the	DET
dti-1378	236	5	gtp	gtp	PROPN
dti-1378	236	6	/	/	SYM
dti-1378	236	7	mg2	mg2	PROPN
dti-1378	236	8	+	+	NOUN
dti-1378	236	9	ion	ion	NOUN
dti-1378	236	10	complex	complex	ADJ
dti-1378	236	11	binding	bind	VERB
dti-1378	236	12	site	site	NOUN
dti-1378	236	13	residues	residue	NOUN
dti-1378	236	14	(	(	PUNCT
dti-1378	236	15	gly46	gly46	NOUN
dti-1378	236	16	,	,	PUNCT
dti-1378	236	17	gly51	gly51	PROPN
dti-1378	236	18	,	,	PUNCT
dti-1378	236	19	lys52	lys52	PROPN
dti-1378	236	20	,	,	PUNCT
dti-1378	236	21	ser53	ser53	PROPN
dti-1378	236	22	,	,	PUNCT
dti-1378	236	23	thr188	thr188	PROPN
dti-1378	236	24	,	,	PUNCT
dti-1378	236	25	asp207	asp207	NOUN
dti-1378	236	26	,	,	PUNCT
dti-1378	236	27	gly210	gly210	PROPN
dti-1378	236	28	,	,	PUNCT
dti-1378	236	29	asn276	asn276	PROPN
dti-1378	236	30	,	,	PUNCT
dti-1378	236	31	lys277	lys277	PROPN
dti-1378	236	32	,	,	PUNCT
dti-1378	236	33	asp279	asp279	PROPN
dti-1378	236	34	,	,	PUNCT
dti-1378	236	35	cys350	cys350	PROPN
dti-1378	236	36	,	,	PUNCT
dti-1378	236	37	ala351	ala351	NOUN
dti-1378	236	38	;	;	PUNCT
dti-1378	236	39	green	green	ADJ
dti-1378	236	40	)	)	PUNCT
dti-1378	236	41	are	be	AUX
dti-1378	236	42	located	locate	VERB
dti-1378	236	43	on	on	ADP
dti-1378	236	44	the	the	DET
dti-1378	236	45	loops	loop	NOUN
dti-1378	236	46	,	,	PUNCT
dti-1378	236	47	helices	helix	NOUN
dti-1378	236	48	and	and	CCONJ
dti-1378	236	49	the	the	DET
dti-1378	236	50	β	β	NOUN
dti-1378	236	51	sheets	sheet	NOUN
dti-1378	236	52	.	.	PUNCT
dti-1378	237	1	the	the	DET
dti-1378	237	2	adenylyl	adenylyl	NOUN
dti-1378	237	3	cyclase	cyclase	NOUN
dti-1378	237	4	interaction	interaction	NOUN
dti-1378	237	5	site	site	NOUN
dti-1378	237	6	residues	residue	NOUN
dti-1378	237	7	(	(	PUNCT
dti-1378	237	8	ile191	ile191	PROPN
dti-1378	237	9	,	,	PUNCT
dti-1378	237	10	arg216	arg216	PROPN
dti-1378	237	11	,	,	PUNCT
dti-1378	237	12	ile219	ile219	PROPN
dti-1378	237	13	,	,	PUNCT
dti-1378	237	14	gln220	gln220	PROPN
dti-1378	237	15	,	,	PUNCT
dti-1378	237	16	and	and	CCONJ
dti-1378	237	17	asn223	asn223	PROPN
dti-1378	237	18	;	;	PUNCT
dti-1378	237	19	black	black	ADJ
dti-1378	237	20	)	)	PUNCT
dti-1378	237	21	are	be	AUX
dti-1378	237	22	located	locate	VERB
dti-1378	237	23	on	on	ADP
dti-1378	237	24	the	the	DET
dti-1378	237	25	loops	loop	NOUN
dti-1378	237	26	and	and	CCONJ
dti-1378	237	27	helices	helix	NOUN
dti-1378	237	28	.	.	PUNCT
dti-1378	238	1	(	(	PUNCT
dti-1378	238	2	b	b	X
dti-1378	238	3	)	)	PUNCT
dti-1378	238	4	on	on	ADP
dti-1378	238	5	the	the	DET
dti-1378	238	6	folded	fold	VERB
dti-1378	238	7	structure	structure	NOUN
dti-1378	238	8	the	the	DET
dti-1378	238	9	gtp	gtp	PROPN
dti-1378	238	10	/	/	SYM
dti-1378	238	11	mg2	mg2	PROPN
dti-1378	238	12	+	+	NOUN
dti-1378	238	13	ion	ion	NOUN
dti-1378	238	14	complex	complex	ADJ
dti-1378	238	15	binding	bind	VERB
dti-1378	238	16	site	site	NOUN
dti-1378	238	17	residues	residue	NOUN
dti-1378	238	18	are	be	AUX
dti-1378	238	19	situated	situate	VERB
dti-1378	238	20	in	in	ADP
dti-1378	238	21	the	the	DET
dti-1378	238	22	active	active	ADJ
dti-1378	238	23	site	site	NOUN
dti-1378	238	24	(	(	PUNCT
dti-1378	238	25	fold	fold	ADJ
dti-1378	238	26	)	)	PUNCT
dti-1378	238	27	of	of	ADP
dti-1378	238	28	the	the	DET
dti-1378	238	29	protein	protein	NOUN
dti-1378	238	30	that	that	PRON
dti-1378	238	31	extends	extend	VERB
dti-1378	238	32	to	to	ADP
dti-1378	238	33	the	the	DET
dti-1378	238	34	outer	outer	ADJ
dti-1378	238	35	side	side	NOUN
dti-1378	238	36	through	through	ADP
dti-1378	238	37	a	a	DET
dti-1378	238	38	hollow	hollow	ADJ
dti-1378	238	39	cavity	cavity	NOUN
dti-1378	238	40	cutting	cut	VERB
dti-1378	238	41	across	across	ADP
dti-1378	238	42	the	the	DET
dti-1378	238	43	protein	protein	NOUN
dti-1378	238	44	internal	internal	ADJ
dti-1378	238	45	structure	structure	NOUN
dti-1378	238	46	.	.	PUNCT
dti-1378	239	1	the	the	DET
dti-1378	239	2	adenylyl	adenylyl	NOUN
dti-1378	239	3	cyclase	cyclase	NOUN
dti-1378	239	4	interaction	interaction	NOUN
dti-1378	239	5	site	site	NOUN
dti-1378	239	6	residues	residue	NOUN
dti-1378	239	7	are	be	AUX
dti-1378	239	8	localized	localize	VERB
dti-1378	239	9	on	on	ADP
dti-1378	239	10	the	the	DET
dti-1378	239	11	surface	surface	NOUN
dti-1378	239	12	of	of	ADP
dti-1378	239	13	the	the	DET
dti-1378	239	14	protein	protein	NOUN
dti-1378	239	15	.	.	PUNCT
dti-1378	240	1	figure	figure	NOUN
dti-1378	240	2	9	9	NUM
dti-1378	240	3	.	.	PUNCT
dti-1378	241	1	the	the	DET
dti-1378	241	2	distribution	distribution	NOUN
dti-1378	241	3	of	of	ADP
dti-1378	241	4	beta	beta	NOUN
dti-1378	241	5	-	-	PUNCT
dti-1378	241	6	gamma	gamma	NOUN
dti-1378	241	7	an	an	DET
dti-1378	241	8	goloco	goloco	ADJ
dti-1378	241	9	binding	bind	VERB
dti-1378	241	10	site	site	NOUN
dti-1378	241	11	residues	residue	NOUN
dti-1378	241	12	on	on	ADP
dti-1378	241	13	the	the	DET
dti-1378	241	14	3	3	NUM
dti-1378	241	15	-	-	PUNCT
dti-1378	241	16	dimensional	dimensional	ADJ
dti-1378	241	17	structure	structure	NOUN
dti-1378	241	18	of	of	ADP
dti-1378	241	19	schistosoma	schistosoma	ADJ
dti-1378	241	20	mansoni	mansoni	ADJ
dti-1378	241	21	smp_059340.1	smp_059340.1	PROPN
dti-1378	241	22	.	.	PUNCT
dti-1378	242	1	(	(	PUNCT
dti-1378	242	2	a	a	X
dti-1378	242	3	)	)	PUNCT
dti-1378	242	4	beta	beta	NOUN
dti-1378	242	5	-	-	PUNCT
dti-1378	242	6	gamma	gamma	NOUN
dti-1378	242	7	residues	residue	NOUN
dti-1378	242	8	(	(	PUNCT
dti-1378	242	9	ser189	ser189	PROPN
dti-1378	242	10	,	,	PUNCT
dti-1378	242	11	ile191	ile191	PROPN
dti-1378	242	12	,	,	PUNCT
dti-1378	242	13	glu193	glu193	PROPN
dti-1378	242	14	,	,	PUNCT
dti-1378	242	15	his204	his204	PROPN
dti-1378	242	16	,	,	PUNCT
dti-1378	242	17	phe206	phe206	PROPN
dti-1378	242	18	,	,	PUNCT
dti-1378	242	19	gly210	gly210	PROPN
dti-1378	242	20	,	,	PUNCT
dti-1378	242	21	gln211	gln211	PROPN
dti-1378	242	22	,	,	PUNCT
dti-1378	242	23	arg212	arg212	PROPN
dti-1378	242	24	,	,	PUNCT
dti-1378	242	25	glu214	glu214	ADJ
dti-1378	242	26	,	,	PUNCT
dti-1378	242	27	lys217	lys217	PROPN
dti-1378	242	28	,	,	PUNCT
dti-1378	242	29	trp218	trp218	PROPN
dti-1378	242	30	,	,	PUNCT
dti-1378	242	31	gln220	gln220	PROPN
dti-1378	242	32	,	,	PUNCT
dti-1378	242	33	cys221	cys221	NOUN
dti-1378	242	34	,	,	PUNCT
dti-1378	242	35	phe222	phe222	PROPN
dti-1378	242	36	,	,	PUNCT
dti-1378	242	37	asn223	asn223	PROPN
dti-1378	242	38	;	;	PUNCT
dti-1378	242	39	green	green	ADJ
dti-1378	242	40	)	)	PUNCT
dti-1378	242	41	are	be	AUX
dti-1378	242	42	located	locate	VERB
dti-1378	242	43	on	on	ADP
dti-1378	242	44	the	the	DET
dti-1378	242	45	helix	helix	NOUN
dti-1378	242	46	,	,	PUNCT
dti-1378	242	47	loop	loop	NOUN
dti-1378	242	48	and	and	CCONJ
dti-1378	242	49	β	β	NOUN
dti-1378	242	50	sheets	sheet	NOUN
dti-1378	242	51	.	.	PUNCT
dti-1378	243	1	the	the	DET
dti-1378	243	2	goloco	goloco	NOUN
dti-1378	243	3	binding	bind	VERB
dti-1378	243	4	site	site	NOUN
dti-1378	243	5	residues	residue	NOUN
dti-1378	243	6	(	(	PUNCT
dti-1378	243	7	ala47	ala47	NOUN
dti-1378	243	8	,	,	PUNCT
dti-1378	243	9	gly48	gly48	PROPN
dti-1378	243	10	,	,	PUNCT
dti-1378	243	11	glu49	glu49	NOUN
dti-1378	243	12	,	,	PUNCT
dti-1378	243	13	asp77	asp77	PROPN
dti-1378	243	14	,	,	PUNCT
dti-1378	243	15	lys81	lys81	VERB
dti-1378	243	16	,	,	PUNCT
dti-1378	243	17	asp85	asp85	PROPN
dti-1378	243	18	,	,	PUNCT
dti-1378	243	19	cys88	cys88	PROPN
dti-1378	243	20	,	,	PUNCT
dti-1378	243	21	ala91	ala91	NOUN
dti-1378	243	22	,	,	PUNCT
dti-1378	243	23	gly92	gly92	PROPN
dti-1378	243	24	,	,	PUNCT
dti-1378	243	25	arg112	arg112	PROPN
dti-1378	243	26	,	,	PUNCT
dti-1378	243	27	ile115	ile115	PROPN
dti-1378	243	28	,	,	PUNCT
dti-1378	243	29	ile156	ile156	PROPN
dti-1378	243	30	,	,	PUNCT
dti-1378	243	31	arg185	arg185	PROPN
dti-1378	243	32	,	,	PUNCT
dti-1378	243	33	gly210	gly210	PROPN
dti-1378	243	34	,	,	PUNCT
dti-1378	243	35	trp218	trp218	PROPN
dti-1378	243	36	,	,	PUNCT
dti-1378	243	37	phe222	phe222	PROPN
dti-1378	243	38	;	;	PUNCT
dti-1378	243	39	black	black	ADJ
dti-1378	243	40	)	)	PUNCT
dti-1378	243	41	are	be	AUX
dti-1378	243	42	located	locate	VERB
dti-1378	243	43	on	on	ADP
dti-1378	243	44	the	the	DET
dti-1378	243	45	helices	helix	NOUN
dti-1378	243	46	and	and	CCONJ
dti-1378	243	47	the	the	DET
dti-1378	243	48	loops	loop	NOUN
dti-1378	243	49	.	.	PUNCT
dti-1378	244	1	the	the	DET
dti-1378	244	2	common	common	ADJ
dti-1378	244	3	residues	residue	NOUN
dti-1378	244	4	shared	share	VERB
dti-1378	244	5	between	between	ADP
dti-1378	244	6	both	both	DET
dti-1378	244	7	domains	domain	NOUN
dti-1378	244	8	(	(	PUNCT
dti-1378	244	9	gly210	gly210	NOUN
dti-1378	244	10	,	,	PUNCT
dti-1378	244	11	trp218	trp218	PROPN
dti-1378	244	12	and	and	CCONJ
dti-1378	244	13	phe222	phe222	PROPN
dti-1378	244	14	)	)	PUNCT
dti-1378	244	15	are	be	AUX
dti-1378	244	16	depicted	depict	VERB
dti-1378	244	17	blue	blue	ADJ
dti-1378	244	18	.	.	PUNCT
dti-1378	245	1	(	(	PUNCT
dti-1378	245	2	b	b	X
dti-1378	245	3	)	)	PUNCT
dti-1378	245	4	on	on	ADP
dti-1378	245	5	the	the	DET
dti-1378	245	6	folded	fold	VERB
dti-1378	245	7	structure	structure	NOUN
dti-1378	245	8	the	the	DET
dti-1378	245	9	beta	beta	NOUN
dti-1378	245	10	-	-	PUNCT
dti-1378	245	11	gamma	gamma	NOUN
dti-1378	245	12	complex	complex	ADJ
dti-1378	245	13	site	site	NOUN
dti-1378	245	14	(	(	PUNCT
dti-1378	245	15	green	green	NOUN
dti-1378	245	16	)	)	PUNCT
dti-1378	245	17	is	be	AUX
dti-1378	245	18	positioned	position	VERB
dti-1378	245	19	on	on	ADP
dti-1378	245	20	the	the	DET
dti-1378	245	21	surface	surface	NOUN
dti-1378	245	22	in	in	ADP
dti-1378	245	23	close	close	ADJ
dti-1378	245	24	proximity	proximity	NOUN
dti-1378	245	25	to	to	ADP
dti-1378	245	26	the	the	DET
dti-1378	245	27	location	location	NOUN
dti-1378	245	28	of	of	ADP
dti-1378	245	29	the	the	DET
dti-1378	245	30	gtp	gtp	PROPN
dti-1378	245	31	/	/	SYM
dti-1378	245	32	mg2	mg2	PROPN
dti-1378	245	33	+	+	NOUN
dti-1378	245	34	ion	ion	NOUN
dti-1378	245	35	complex	complex	ADJ
dti-1378	245	36	binding	bind	VERB
dti-1378	245	37	site	site	NOUN
dti-1378	245	38	at	at	ADP
dti-1378	245	39	residue	residue	NOUN
dti-1378	245	40	gly210	gly210	NOUN
dti-1378	245	41	and	and	CCONJ
dti-1378	245	42	adenylyl	adenylyl	NOUN
dti-1378	245	43	cyclase	cyclase	NOUN
dti-1378	245	44	interaction	interaction	NOUN
dti-1378	245	45	site	site	NOUN
dti-1378	245	46	(	(	PUNCT
dti-1378	245	47	ile191,gln220	ile191,gln220	NOUN
dti-1378	245	48	and	and	CCONJ
dti-1378	245	49	asn223	asn223	PROPN
dti-1378	245	50	;	;	PUNCT
dti-1378	245	51	fig	fig	NOUN
dti-1378	245	52	.	.	PUNCT
dti-1378	246	1	5	5	NUM
dti-1378	246	2	)	)	PUNCT
dti-1378	246	3	.	.	PUNCT
dti-1378	247	1	the	the	DET
dti-1378	247	2	goloco	goloco	ADJ
dti-1378	247	3	binding	bind	VERB
dti-1378	247	4	site	site	NOUN
dti-1378	247	5	is	be	AUX
dti-1378	247	6	situated	situate	VERB
dti-1378	247	7	exposed	expose	VERB
dti-1378	247	8	on	on	ADP
dti-1378	247	9	the	the	DET
dti-1378	247	10	surface	surface	NOUN
dti-1378	247	11	with	with	ADP
dti-1378	247	12	extension	extension	NOUN
dti-1378	247	13	into	into	ADP
dti-1378	247	14	the	the	DET
dti-1378	247	15	gtp	gtp	PROPN
dti-1378	247	16	/	/	SYM
dti-1378	247	17	mg2	mg2	PROPN
dti-1378	247	18	+	+	NOUN
dti-1378	247	19	ion	ion	NOUN
dti-1378	247	20	complex	complex	NOUN
dti-1378	247	21	site	site	NOUN
dti-1378	247	22	at	at	ADP
dti-1378	247	23	gly210	gly210	PROPN
dti-1378	247	24	(	(	PUNCT
dti-1378	247	25	fig	fig	NOUN
dti-1378	247	26	.	.	PUNCT
dti-1378	248	1	8)	8)	NUM
dti-1378	248	2	.	.	PUNCT
dti-1378	248	3	http://www.la-press.com	http://www.la-press.com	X
dti-1378	248	4	drug	drug	NOUN
dti-1378	248	5	target	target	NOUN
dti-1378	248	6	features	feature	NOUN
dti-1378	248	7	of	of	ADP
dti-1378	248	8	schistosoma	schistosoma	ADJ
dti-1378	248	9	adenylyl	adenylyl	NOUN
dti-1378	248	10	cyclase	cyclase	NOUN
dti-1378	248	11	activity	activity	NOUN
dti-1378	248	12	drug	drug	NOUN
dti-1378	248	13	target	target	NOUN
dti-1378	248	14	insights	insight	NOUN
dti-1378	248	15	2012:6	2012:6	NUM
dti-1378	248	16	51	51	NUM
dti-1378	248	17	binding	bind	VERB
dti-1378	248	18	site	site	NOUN
dti-1378	248	19	also	also	ADV
dti-1378	248	20	shares	share	VERB
dti-1378	248	21	conserved	conserve	VERB
dti-1378	248	22	residues	residue	NOUN
dti-1378	248	23	with	with	ADP
dti-1378	248	24	the	the	DET
dti-1378	248	25	gtp	gtp	PROPN
dti-1378	248	26	/	/	SYM
dti-1378	248	27	mg2	mg2	PROPN
dti-1378	248	28	+	+	NOUN
dti-1378	248	29	ion	ion	NOUN
dti-1378	248	30	complex	complex	NOUN
dti-1378	248	31	site	site	NOUN
dti-1378	248	32	and	and	CCONJ
dti-1378	248	33	the	the	DET
dti-1378	248	34	g3	g3	PROPN
dti-1378	248	35	box	box	NOUN
dti-1378	248	36	motif	motif	NOUN
dti-1378	248	37	.	.	PUNCT
dti-1378	249	1	putative	putative	ADJ
dti-1378	249	2	receptor	receptor	NOUN
dti-1378	249	3	binding	bind	VERB
dti-1378	249	4	site	site	NOUN
dti-1378	249	5	domain	domain	VERB
dti-1378	249	6	the	the	DET
dti-1378	249	7	putative	putative	ADJ
dti-1378	249	8	receptor	receptor	NOUN
dti-1378	249	9	conserved	conserve	VERB
dti-1378	249	10	residues	residue	NOUN
dti-1378	249	11	(	(	PUNCT
dti-1378	249	12	red	red	ADJ
dti-1378	249	13	)	)	PUNCT
dti-1378	249	14	are	be	AUX
dti-1378	249	15	positioned	position	VERB
dti-1378	249	16	on	on	ADP
dti-1378	249	17	a	a	DET
dti-1378	249	18	loop	loop	NOUN
dti-1378	249	19	and	and	CCONJ
dti-1378	249	20	helix	helix	NOUN
dti-1378	249	21	(	(	PUNCT
dti-1378	249	22	fig	fig	NOUN
dti-1378	249	23	.	.	PUNCT
dti-1378	249	24	10a	10a	NOUN
dti-1378	249	25	)	)	PUNCT
dti-1378	249	26	.	.	PUNCT
dti-1378	250	1	on	on	ADP
dti-1378	250	2	the	the	DET
dti-1378	250	3	protein	protein	NOUN
dti-1378	250	4	-	-	PUNCT
dti-1378	250	5	folded	fold	VERB
dti-1378	250	6	structure	structure	NOUN
dti-1378	250	7	,	,	PUNCT
dti-1378	250	8	the	the	DET
dti-1378	250	9	receptor	receptor	NOUN
dti-1378	250	10	binding	bind	VERB
dti-1378	250	11	site	site	NOUN
dti-1378	250	12	(	(	PUNCT
dti-1378	250	13	red	red	ADJ
dti-1378	250	14	)	)	PUNCT
dti-1378	250	15	stretches	stretch	NOUN
dti-1378	250	16	from	from	ADP
dti-1378	250	17	within	within	ADP
dti-1378	250	18	the	the	DET
dti-1378	250	19	inner	inner	ADJ
dti-1378	250	20	active	active	ADJ
dti-1378	250	21	cavity	cavity	NOUN
dti-1378	250	22	where	where	SCONJ
dti-1378	250	23	it	it	PRON
dti-1378	250	24	shares	share	VERB
dti-1378	250	25	two	two	NUM
dti-1378	250	26	residues	residue	NOUN
dti-1378	250	27	with	with	ADP
dti-1378	250	28	the	the	DET
dti-1378	250	29	gtp	gtp	PROPN
dti-1378	250	30	/	/	SYM
dti-1378	250	31	mg2	mg2	PROPN
dti-1378	250	32	+	+	NOUN
dti-1378	250	33	ion	ion	NOUN
dti-1378	250	34	complex	complex	ADJ
dti-1378	250	35	binding	bind	VERB
dti-1378	250	36	site	site	NOUN
dti-1378	250	37	at	at	ADP
dti-1378	250	38	cys350	cys350	PROPN
dti-1378	250	39	and	and	CCONJ
dti-1378	250	40	ala351	ala351	NOUN
dti-1378	250	41	to	to	ADP
dti-1378	250	42	the	the	DET
dti-1378	250	43	surface	surface	NOUN
dti-1378	250	44	of	of	ADP
dti-1378	250	45	the	the	DET
dti-1378	250	46	protein	protein	NOUN
dti-1378	250	47	(	(	PUNCT
dti-1378	250	48	fig	fig	NOUN
dti-1378	250	49	.	.	PUNCT
dti-1378	250	50	10b	10b	NOUN
dti-1378	250	51	)	)	PUNCT
dti-1378	250	52	.	.	PUNCT
dti-1378	251	1	it	it	PRON
dti-1378	251	2	also	also	ADV
dti-1378	251	3	shares	share	VERB
dti-1378	251	4	all	all	DET
dti-1378	251	5	3	3	NUM
dti-1378	251	6	conserved	conserved	ADJ
dti-1378	251	7	residues	residue	NOUN
dti-1378	251	8	(	(	PUNCT
dti-1378	251	9	cys350	cys350	NOUN
dti-1378	251	10	,	,	PUNCT
dti-1378	251	11	ala351	ala351	NOUN
dti-1378	251	12	and	and	CCONJ
dti-1378	251	13	valine	valine	NOUN
dti-1378	251	14	(	(	PUNCT
dti-1378	251	15	val)352	val)352	NOUN
dti-1378	251	16	)	)	PUNCT
dti-1378	251	17	found	find	VERB
dti-1378	251	18	in	in	ADP
dti-1378	251	19	g5	g5	PROPN
dti-1378	251	20	box	box	NOUN
dti-1378	251	21	motif	motif	NOUN
dti-1378	251	22	.	.	PUNCT
dti-1378	252	1	hence	hence	ADV
dti-1378	252	2	the	the	DET
dti-1378	252	3	g5	g5	PROPN
dti-1378	252	4	box	box	NOUN
dti-1378	252	5	motif	motif	NOUN
dti-1378	252	6	is	be	AUX
dti-1378	252	7	part	part	NOUN
dti-1378	252	8	of	of	ADP
dti-1378	252	9	the	the	DET
dti-1378	252	10	putative	putative	ADJ
dti-1378	252	11	receptor	receptor	NOUN
dti-1378	252	12	binding	bind	VERB
dti-1378	252	13	site	site	NOUN
dti-1378	252	14	,	,	PUNCT
dti-1378	252	15	and	and	CCONJ
dti-1378	252	16	functions	function	NOUN
dti-1378	252	17	as	as	ADP
dti-1378	252	18	a	a	DET
dti-1378	252	19	buttress	buttress	ADJ
dti-1378	252	20	factor	factor	NOUN
dti-1378	252	21	for	for	ADP
dti-1378	252	22	the	the	DET
dti-1378	252	23	guanine	guanine	NOUN
dti-1378	252	24	base	base	PROPN
dti-1378	252	25	recognition	recognition	NOUN
dti-1378	252	26	site	site	NOUN
dti-1378	252	27	.	.	PUNCT
dti-1378	253	1	switch	switch	VERB
dti-1378	253	2	i	i	PRON
dti-1378	253	3	and	and	CCONJ
dti-1378	253	4	switch	switch	VERB
dti-1378	253	5	ii	ii	PROPN
dti-1378	253	6	region	region	NOUN
dti-1378	253	7	domains	domain	VERB
dti-1378	253	8	the	the	DET
dti-1378	253	9	switch	switch	NOUN
dti-1378	253	10	i	i	PRON
dti-1378	253	11	residues	residue	VERB
dti-1378	253	12	(	(	PUNCT
dti-1378	253	13	green	green	ADJ
dti-1378	253	14	)	)	PUNCT
dti-1378	253	15	are	be	AUX
dti-1378	253	16	located	locate	VERB
dti-1378	253	17	on	on	ADP
dti-1378	253	18	the	the	DET
dti-1378	253	19	loop	loop	NOUN
dti-1378	253	20	and	and	CCONJ
dti-1378	253	21	helix	helix	NOUN
dti-1378	253	22	,	,	PUNCT
dti-1378	253	23	while	while	SCONJ
dti-1378	253	24	switch	switch	VERB
dti-1378	253	25	ii	ii	NOUN
dti-1378	253	26	residues	residue	NOUN
dti-1378	253	27	(	(	PUNCT
dti-1378	253	28	yellow	yellow	ADJ
dti-1378	253	29	)	)	PUNCT
dti-1378	253	30	are	be	AUX
dti-1378	253	31	also	also	ADV
dti-1378	253	32	situated	situate	VERB
dti-1378	253	33	on	on	ADP
dti-1378	253	34	the	the	DET
dti-1378	253	35	loop	loop	NOUN
dti-1378	253	36	and	and	CCONJ
dti-1378	253	37	helix	helix	NOUN
dti-1378	253	38	.	.	PUNCT
dti-1378	254	1	both	both	DET
dti-1378	254	2	molecular	molecular	ADJ
dti-1378	254	3	switches	switch	NOUN
dti-1378	254	4	cycle	cycle	NOUN
dti-1378	254	5	between	between	ADP
dti-1378	254	6	an	an	DET
dti-1378	254	7	active	active	ADJ
dti-1378	254	8	state	state	NOUN
dti-1378	254	9	(	(	PUNCT
dti-1378	254	10	gtp	gtp	NOUN
dti-1378	254	11	bound	bind	VERB
dti-1378	254	12	)	)	PUNCT
dti-1378	254	13	and	and	CCONJ
dti-1378	254	14	an	an	DET
dti-1378	254	15	inactive	inactive	ADJ
dti-1378	254	16	state	state	NOUN
dti-1378	254	17	(	(	PUNCT
dti-1378	254	18	gdp	gdp	NOUN
dti-1378	254	19	bound	bind	VERB
dti-1378	254	20	;	;	PUNCT
dti-1378	254	21	fig	fig	NOUN
dti-1378	254	22	.	.	PUNCT
dti-1378	255	1	8a	8a	NUM
dti-1378	255	2	)	)	PUNCT
dti-1378	255	3	.	.	PUNCT
dti-1378	256	1	our	our	PRON
dti-1378	256	2	analysis	analysis	NOUN
dti-1378	256	3	shows	show	VERB
dti-1378	256	4	that	that	SCONJ
dti-1378	256	5	both	both	DET
dti-1378	256	6	switches	switch	NOUN
dti-1378	256	7	are	be	AUX
dti-1378	256	8	located	locate	VERB
dti-1378	256	9	on	on	ADP
dti-1378	256	10	the	the	DET
dti-1378	256	11	outer	outer	ADJ
dti-1378	256	12	surface	surface	NOUN
dti-1378	256	13	of	of	ADP
dti-1378	256	14	the	the	DET
dti-1378	256	15	protein	protein	NOUN
dti-1378	256	16	,	,	PUNCT
dti-1378	256	17	with	with	ADP
dti-1378	256	18	switch	switch	NOUN
dti-1378	256	19	i	i	PRON
dti-1378	256	20	shorter	short	ADJ
dti-1378	256	21	than	than	ADP
dti-1378	256	22	the	the	DET
dti-1378	256	23	switch	switch	NOUN
dti-1378	256	24	ii	ii	PROPN
dti-1378	256	25	region	region	NOUN
dti-1378	256	26	by	by	ADP
dti-1378	256	27	8	8	NUM
dti-1378	256	28	residues	residue	NOUN
dti-1378	256	29	(	(	PUNCT
dti-1378	256	30	table	table	NOUN
dti-1378	256	31	5	5	NUM
dti-1378	256	32	,	,	PUNCT
dti-1378	256	33	fig	fig	NOUN
dti-1378	256	34	.	.	PUNCT
dti-1378	256	35	10b	10b	NOUN
dti-1378	256	36	)	)	PUNCT
dti-1378	256	37	.	.	PUNCT
dti-1378	257	1	these	these	DET
dti-1378	257	2	regions	region	NOUN
dti-1378	257	3	share	share	VERB
dti-1378	257	4	conserved	conserve	VERB
dti-1378	257	5	residues	residue	NOUN
dti-1378	257	6	with	with	ADP
dti-1378	257	7	the	the	DET
dti-1378	257	8	gtp	gtp	PROPN
dti-1378	257	9	/	/	SYM
dti-1378	257	10	mg2	mg2	PROPN
dti-1378	257	11	+	+	NOUN
dti-1378	257	12	ion	ion	NOUN
dti-1378	257	13	complex	complex	NOUN
dti-1378	257	14	,	,	PUNCT
dti-1378	257	15	adenylyl	adenylyl	NOUN
dti-1378	257	16	cyclase	cyclase	NOUN
dti-1378	257	17	interaction	interaction	NOUN
dti-1378	257	18	site	site	NOUN
dti-1378	257	19	,	,	PUNCT
dti-1378	257	20	beta	beta	NOUN
dti-1378	257	21	-	-	PUNCT
dti-1378	257	22	gamma	gamma	NOUN
dti-1378	257	23	complex	complex	NOUN
dti-1378	257	24	,	,	PUNCT
dti-1378	257	25	goloco	goloco	ADJ
dti-1378	257	26	binding	bind	VERB
dti-1378	257	27	site	site	NOUN
dti-1378	257	28	and	and	CCONJ
dti-1378	257	29	the	the	DET
dti-1378	257	30	g2	g2	PROPN
dti-1378	257	31	box	box	NOUN
dti-1378	257	32	motif	motif	NOUN
dti-1378	257	33	(	(	PUNCT
dti-1378	257	34	table	table	NOUN
dti-1378	257	35	5	5	NUM
dti-1378	257	36	)	)	PUNCT
dti-1378	257	37	as	as	SCONJ
dti-1378	257	38	explained	explain	VERB
dti-1378	257	39	above	above	ADV
dti-1378	257	40	.	.	PUNCT
dti-1378	258	1	on	on	ADP
dti-1378	258	2	the	the	DET
dti-1378	258	3	folded	fold	VERB
dti-1378	258	4	protein	protein	NOUN
dti-1378	258	5	structure	structure	NOUN
dti-1378	258	6	the	the	DET
dti-1378	258	7	switch	switch	NOUN
dti-1378	258	8	i	i	PRON
dti-1378	258	9	region	region	NOUN
dti-1378	258	10	(	(	PUNCT
dti-1378	258	11	green	green	NOUN
dti-1378	258	12	)	)	PUNCT
dti-1378	258	13	is	be	AUX
dti-1378	258	14	orientated	orientate	VERB
dti-1378	258	15	on	on	ADP
dti-1378	258	16	the	the	DET
dti-1378	258	17	surface	surface	NOUN
dti-1378	258	18	,	,	PUNCT
dti-1378	258	19	very	very	ADV
dti-1378	258	20	close	close	ADJ
dti-1378	258	21	to	to	ADP
dti-1378	258	22	the	the	DET
dti-1378	258	23	switch	switch	NOUN
dti-1378	258	24	ii	ii	PROPN
dti-1378	258	25	region	region	NOUN
dti-1378	258	26	(	(	PUNCT
dti-1378	258	27	yellow	yellow	ADJ
dti-1378	258	28	;	;	PUNCT
dti-1378	258	29	fig	fig	NOUN
dti-1378	258	30	.	.	PUNCT
dti-1378	258	31	10b	10b	NOUN
dti-1378	258	32	)	)	PUNCT
dti-1378	258	33	.	.	PUNCT
dti-1378	259	1	the	the	DET
dti-1378	259	2	switch	switch	NOUN
dti-1378	259	3	ii	ii	PROPN
dti-1378	259	4	is	be	AUX
dti-1378	259	5	another	another	DET
dti-1378	259	6	region	region	NOUN
dti-1378	259	7	responsible	responsible	ADJ
dti-1378	259	8	for	for	ADP
dti-1378	259	9	the	the	DET
dti-1378	259	10	conformation	conformation	NOUN
dti-1378	259	11	changes	change	NOUN
dti-1378	259	12	between	between	ADP
dti-1378	259	13	the	the	DET
dti-1378	259	14	gtp	gtp	NOUN
dti-1378	259	15	and	and	CCONJ
dti-1378	259	16	the	the	DET
dti-1378	259	17	gdp	gdp	NOUN
dti-1378	259	18	as	as	ADP
dti-1378	259	19	stated	state	VERB
dti-1378	259	20	above	above	ADV
dti-1378	259	21	.	.	PUNCT
dti-1378	260	1	this	this	DET
dti-1378	260	2	switch	switch	NOUN
dti-1378	260	3	ii	ii	PROPN
dti-1378	260	4	region	region	NOUN
dti-1378	260	5	shares	share	NOUN
dti-1378	260	6	conserved	conserve	VERB
dti-1378	260	7	residues	residue	NOUN
dti-1378	260	8	with	with	ADP
dti-1378	260	9	gtp	gtp	PROPN
dti-1378	260	10	/	/	SYM
dti-1378	260	11	mg2	mg2	PROPN
dti-1378	260	12	+	+	NOUN
dti-1378	260	13	ion	ion	NOUN
dti-1378	260	14	complex	complex	NOUN
dti-1378	260	15	,	,	PUNCT
dti-1378	260	16	adenylyl	adenylyl	NOUN
dti-1378	260	17	cyclase	cyclase	NOUN
dti-1378	260	18	interaction	interaction	NOUN
dti-1378	260	19	site	site	NOUN
dti-1378	260	20	,	,	PUNCT
dti-1378	260	21	beta	beta	NOUN
dti-1378	260	22	-	-	PUNCT
dti-1378	260	23	gamma	gamma	NOUN
dti-1378	260	24	complex	complex	NOUN
dti-1378	260	25	,	,	PUNCT
dti-1378	260	26	goloco	goloco	ADJ
dti-1378	260	27	binding	bind	VERB
dti-1378	260	28	site	site	NOUN
dti-1378	260	29	and	and	CCONJ
dti-1378	260	30	the	the	DET
dti-1378	260	31	g3	g3	PROPN
dti-1378	260	32	box	box	NOUN
dti-1378	260	33	motif	motif	NOUN
dti-1378	260	34	(	(	PUNCT
dti-1378	260	35	table	table	NOUN
dti-1378	260	36	5	5	NUM
dti-1378	260	37	)	)	PUNCT
dti-1378	260	38	.	.	PUNCT
dti-1378	261	1	we	we	PRON
dti-1378	261	2	deduced	deduce	VERB
dti-1378	261	3	that	that	SCONJ
dti-1378	261	4	both	both	CCONJ
dti-1378	261	5	the	the	DET
dti-1378	261	6	adenylyl	adenylyl	NOUN
dti-1378	261	7	cyclase	cyclase	NOUN
dti-1378	261	8	binding	bind	VERB
dti-1378	261	9	site	site	NOUN
dti-1378	261	10	(	(	PUNCT
dti-1378	261	11	4	4	NUM
dti-1378	261	12	out	out	ADP
dti-1378	261	13	of	of	ADP
dti-1378	261	14	5	5	NUM
dti-1378	261	15	residues	residue	NOUN
dti-1378	261	16	)	)	PUNCT
dti-1378	261	17	(	(	PUNCT
dti-1378	261	18	arg216	arg216	PROPN
dti-1378	261	19	,	,	PUNCT
dti-1378	261	20	ile219	ile219	PROPN
dti-1378	261	21	,	,	PUNCT
dti-1378	261	22	gln220	gln220	NOUN
dti-1378	261	23	and	and	CCONJ
dti-1378	261	24	asn223	asn223	PROPN
dti-1378	261	25	)	)	PUNCT
dti-1378	261	26	and	and	CCONJ
dti-1378	261	27	the	the	DET
dti-1378	261	28	g3	g3	PROPN
dti-1378	261	29	box	box	NOUN
dti-1378	261	30	motif	motif	NOUN
dti-1378	261	31	(	(	PUNCT
dti-1378	261	32	3	3	NUM
dti-1378	261	33	out	out	ADP
dti-1378	261	34	of	of	ADP
dti-1378	261	35	4	4	NUM
dti-1378	261	36	residues	residue	NOUN
dti-1378	261	37	)	)	PUNCT
dti-1378	261	38	(	(	PUNCT
dti-1378	261	39	val208	val208	NOUN
dti-1378	261	40	,	,	PUNCT
dti-1378	261	41	gly209	gly209	NOUN
dti-1378	261	42	,	,	PUNCT
dti-1378	261	43	gly210	gly210	PROPN
dti-1378	261	44	)	)	PUNCT
dti-1378	261	45	are	be	AUX
dti-1378	261	46	completely	completely	ADV
dti-1378	261	47	integrated	integrate	VERB
dti-1378	261	48	into	into	ADP
dti-1378	261	49	the	the	DET
dti-1378	261	50	switch	switch	NOUN
dti-1378	261	51	ii	ii	PROPN
dti-1378	261	52	region	region	NOUN
dti-1378	261	53	in	in	ADP
dti-1378	261	54	terms	term	NOUN
dti-1378	261	55	of	of	ADP
dti-1378	261	56	their	their	PRON
dti-1378	261	57	shared	share	VERB
dti-1378	261	58	residues	residue	NOUN
dti-1378	261	59	.	.	PUNCT
dti-1378	262	1	g1	g1	NOUN
dti-1378	262	2	-	-	PUNCT
dti-1378	262	3	g5	g5	NOUN
dti-1378	262	4	box	box	NOUN
dti-1378	262	5	motif	motif	NOUN
dti-1378	262	6	domains	domain	VERB
dti-1378	262	7	the	the	DET
dti-1378	262	8	g	g	PROPN
dti-1378	262	9	protein	protein	NOUN
dti-1378	262	10	superfamily	superfamily	ADV
dti-1378	262	11	folds	fold	NOUN
dti-1378	262	12	in	in	ADP
dti-1378	262	13	different	different	ADJ
dti-1378	262	14	variations	variation	NOUN
dti-1378	262	15	depending	depend	VERB
dti-1378	262	16	on	on	ADP
dti-1378	262	17	its	its	PRON
dti-1378	262	18	nucleotide	nucleotide	NOUN
dti-1378	262	19	binding	bind	VERB
dti-1378	262	20	folds.32	folds.32	NOUN
dti-1378	262	21	there	there	PRON
dti-1378	262	22	are	be	VERB
dti-1378	262	23	five	five	NUM
dti-1378	262	24	polypeptide	polypeptide	ADJ
dti-1378	262	25	loops	loop	NOUN
dti-1378	262	26	that	that	PRON
dti-1378	262	27	form	form	VERB
dti-1378	262	28	the	the	DET
dti-1378	262	29	guanine	guanine	NOUN
dti-1378	262	30	nucleotidefigure	nucleotidefigure	NOUN
dti-1378	262	31	10	10	NUM
dti-1378	262	32	.	.	PUNCT
dti-1378	263	1	distribution	distribution	NOUN
dti-1378	263	2	of	of	ADP
dti-1378	263	3	putative	putative	ADJ
dti-1378	263	4	receptor	receptor	NOUN
dti-1378	263	5	,	,	PUNCT
dti-1378	263	6	switch	switch	VERB
dti-1378	263	7	i	i	PRON
dti-1378	263	8	and	and	CCONJ
dti-1378	263	9	switch	switch	VERB
dti-1378	263	10	ii	ii	NOUN
dti-1378	263	11	residues	residue	NOUN
dti-1378	263	12	in	in	ADP
dti-1378	263	13	schistosoma	schistosoma	ADJ
dti-1378	263	14	mansoni	mansoni	ADJ
dti-1378	263	15	smp_059340.1	smp_059340.1	PROPN
dti-1378	263	16	.	.	PUNCT
dti-1378	264	1	(	(	PUNCT
dti-1378	264	2	a	a	X
dti-1378	264	3	)	)	PUNCT
dti-1378	264	4	the	the	DET
dti-1378	264	5	putative	putative	ADJ
dti-1378	264	6	receptor	receptor	NOUN
dti-1378	264	7	conserved	conserve	VERB
dti-1378	264	8	residues	residue	NOUN
dti-1378	264	9	(	(	PUNCT
dti-1378	264	10	red	red	ADJ
dti-1378	264	11	)	)	PUNCT
dti-1378	264	12	are	be	AUX
dti-1378	264	13	positioned	position	VERB
dti-1378	264	14	on	on	ADP
dti-1378	264	15	the	the	DET
dti-1378	264	16	loop	loop	NOUN
dti-1378	264	17	and	and	CCONJ
dti-1378	264	18	helix	helix	NOUN
dti-1378	264	19	;	;	PUNCT
dti-1378	264	20	switch	switch	VERB
dti-1378	264	21	i	i	PRON
dti-1378	264	22	residues	residue	VERB
dti-1378	264	23	(	(	PUNCT
dti-1378	264	24	green	green	ADJ
dti-1378	264	25	)	)	PUNCT
dti-1378	264	26	are	be	AUX
dti-1378	264	27	located	locate	VERB
dti-1378	264	28	on	on	ADP
dti-1378	264	29	the	the	DET
dti-1378	264	30	loop	loop	NOUN
dti-1378	264	31	and	and	CCONJ
dti-1378	264	32	helix	helix	NOUN
dti-1378	264	33	while	while	SCONJ
dti-1378	264	34	switch	switch	VERB
dti-1378	264	35	ii	ii	NOUN
dti-1378	264	36	residues	residue	NOUN
dti-1378	264	37	(	(	PUNCT
dti-1378	264	38	yellow	yellow	ADJ
dti-1378	264	39	)	)	PUNCT
dti-1378	264	40	are	be	AUX
dti-1378	264	41	also	also	ADV
dti-1378	264	42	situated	situate	VERB
dti-1378	264	43	on	on	ADP
dti-1378	264	44	the	the	DET
dti-1378	264	45	loop	loop	NOUN
dti-1378	264	46	and	and	CCONJ
dti-1378	264	47	helix	helix	NOUN
dti-1378	264	48	.	.	PUNCT
dti-1378	265	1	(	(	PUNCT
dti-1378	265	2	b	b	X
dti-1378	265	3	)	)	PUNCT
dti-1378	265	4	on	on	ADP
dti-1378	265	5	the	the	DET
dti-1378	265	6	folded	fold	VERB
dti-1378	265	7	structure	structure	NOUN
dti-1378	265	8	the	the	DET
dti-1378	265	9	putative	putative	ADJ
dti-1378	265	10	receptor	receptor	NOUN
dti-1378	265	11	conserved	conserve	VERB
dti-1378	265	12	residues	residue	NOUN
dti-1378	265	13	(	(	PUNCT
dti-1378	265	14	ted	ted	ADJ
dti-1378	265	15	)	)	PUNCT
dti-1378	265	16	stretches	stretch	NOUN
dti-1378	265	17	from	from	ADP
dti-1378	265	18	within	within	ADP
dti-1378	265	19	the	the	DET
dti-1378	265	20	inner	inner	ADJ
dti-1378	265	21	active	active	ADJ
dti-1378	265	22	cavity	cavity	NOUN
dti-1378	265	23	were	be	AUX
dti-1378	265	24	it	it	PRON
dti-1378	265	25	shares	share	VERB
dti-1378	265	26	two	two	NUM
dti-1378	265	27	residues	residue	NOUN
dti-1378	265	28	with	with	ADP
dti-1378	265	29	the	the	DET
dti-1378	265	30	gtp	gtp	PROPN
dti-1378	265	31	/	/	SYM
dti-1378	265	32	mg2	mg2	PROPN
dti-1378	265	33	+	+	NOUN
dti-1378	265	34	ion	ion	NOUN
dti-1378	265	35	complex	complex	ADJ
dti-1378	265	36	binding	bind	VERB
dti-1378	265	37	site	site	NOUN
dti-1378	265	38	at	at	ADP
dti-1378	265	39	cys350	cys350	PROPN
dti-1378	265	40	and	and	CCONJ
dti-1378	265	41	ala351	ala351	NOUN
dti-1378	265	42	to	to	ADP
dti-1378	265	43	the	the	DET
dti-1378	265	44	surface	surface	NOUN
dti-1378	265	45	of	of	ADP
dti-1378	265	46	the	the	DET
dti-1378	265	47	protein	protein	NOUN
dti-1378	265	48	.	.	PUNCT
dti-1378	266	1	both	both	PRON
dti-1378	266	2	switch	switch	VERB
dti-1378	266	3	i	i	PRON
dti-1378	266	4	(	(	PUNCT
dti-1378	266	5	green	green	ADJ
dti-1378	266	6	)	)	PUNCT
dti-1378	266	7	and	and	CCONJ
dti-1378	266	8	switch	switch	VERB
dti-1378	266	9	ii	ii	PROPN
dti-1378	266	10	(	(	PUNCT
dti-1378	266	11	yellow	yellow	ADJ
dti-1378	266	12	)	)	PUNCT
dti-1378	266	13	regions	region	NOUN
dti-1378	266	14	are	be	AUX
dti-1378	266	15	orientated	orientate	VERB
dti-1378	266	16	on	on	ADP
dti-1378	266	17	the	the	DET
dti-1378	266	18	surface	surface	NOUN
dti-1378	266	19	close	close	ADV
dti-1378	266	20	to	to	ADP
dti-1378	266	21	each	each	DET
dti-1378	266	22	other	other	ADJ
dti-1378	266	23	.	.	PUNCT
dti-1378	267	1	switch	switch	NOUN
dti-1378	267	2	i	i	PRON
dti-1378	267	3	is	be	AUX
dti-1378	267	4	shorter	short	ADJ
dti-1378	267	5	than	than	ADP
dti-1378	267	6	the	the	DET
dti-1378	267	7	switch	switch	NOUN
dti-1378	267	8	ii	ii	PROPN
dti-1378	267	9	region	region	NOUN
dti-1378	267	10	by	by	ADP
dti-1378	267	11	8	8	NUM
dti-1378	267	12	residues	residue	NOUN
dti-1378	267	13	.	.	PUNCT
dti-1378	268	1	these	these	DET
dti-1378	268	2	regions	region	NOUN
dti-1378	268	3	shares	share	VERB
dti-1378	268	4	conserved	conserve	VERB
dti-1378	268	5	residues	residue	NOUN
dti-1378	268	6	with	with	ADP
dti-1378	268	7	gtp	gtp	PROPN
dti-1378	268	8	/	/	SYM
dti-1378	268	9	mg2	mg2	PROPN
dti-1378	268	10	+	+	NOUN
dti-1378	268	11	ion	ion	NOUN
dti-1378	268	12	complex	complex	NOUN
dti-1378	268	13	,	,	PUNCT
dti-1378	268	14	adenylyl	adenylyl	NOUN
dti-1378	268	15	cyclase	cyclase	NOUN
dti-1378	268	16	interaction	interaction	NOUN
dti-1378	268	17	site	site	NOUN
dti-1378	268	18	and	and	CCONJ
dti-1378	268	19	beta	beta	NOUN
dti-1378	268	20	–	–	PUNCT
dti-1378	268	21	gamma	gamma	NOUN
dti-1378	268	22	complex	complex	NOUN
dti-1378	268	23	,	,	PUNCT
dti-1378	268	24	goloco	goloco	ADJ
dti-1378	268	25	binding	bind	VERB
dti-1378	268	26	site	site	NOUN
dti-1378	268	27	as	as	SCONJ
dti-1378	268	28	shown	show	VERB
dti-1378	268	29	above	above	ADV
dti-1378	268	30	.	.	PUNCT
dti-1378	269	1	figure	figure	VERB
dti-1378	269	2	11	11	NUM
dti-1378	269	3	.	.	PUNCT
dti-1378	270	1	distribution	distribution	NOUN
dti-1378	270	2	of	of	ADP
dti-1378	270	3	g	g	PROPN
dti-1378	270	4	box	box	NOUN
dti-1378	270	5	motifs	motif	NOUN
dti-1378	270	6	labeled	label	VERB
dti-1378	270	7	g1	g1	PROPN
dti-1378	270	8	-	-	PUNCT
dti-1378	270	9	g5	g5	NOUN
dti-1378	270	10	residues	residue	NOUN
dti-1378	270	11	of	of	ADP
dti-1378	270	12	schistosoma	schistosoma	ADJ
dti-1378	270	13	mansoni	mansoni	ADJ
dti-1378	270	14	smp_059340.1	smp_059340.1	PROPN
dti-1378	270	15	.	.	PUNCT
dti-1378	271	1	(	(	PUNCT
dti-1378	271	2	a	a	X
dti-1378	271	3	)	)	PUNCT
dti-1378	271	4	the	the	DET
dti-1378	271	5	g1	g1	PROPN
dti-1378	271	6	box	box	NOUN
dti-1378	271	7	motif	motif	NOUN
dti-1378	271	8	(	(	PUNCT
dti-1378	271	9	red	red	ADJ
dti-1378	271	10	)	)	PUNCT
dti-1378	271	11	is	be	AUX
dti-1378	271	12	located	locate	VERB
dti-1378	271	13	on	on	ADP
dti-1378	271	14	the	the	DET
dti-1378	271	15	loop	loop	NOUN
dti-1378	271	16	,	,	PUNCT
dti-1378	271	17	sheet	sheet	NOUN
dti-1378	271	18	and	and	CCONJ
dti-1378	271	19	the	the	DET
dti-1378	271	20	helix	helix	NOUN
dti-1378	271	21	while	while	SCONJ
dti-1378	271	22	the	the	DET
dti-1378	271	23	g2	g2	PROPN
dti-1378	271	24	box	box	NOUN
dti-1378	271	25	motif	motif	NOUN
dti-1378	271	26	(	(	PUNCT
dti-1378	271	27	green	green	ADJ
dti-1378	271	28	)	)	PUNCT
dti-1378	271	29	is	be	AUX
dti-1378	271	30	located	locate	VERB
dti-1378	271	31	on	on	ADP
dti-1378	271	32	the	the	DET
dti-1378	271	33	loop	loop	NOUN
dti-1378	271	34	and	and	CCONJ
dti-1378	271	35	contains	contain	VERB
dti-1378	271	36	only	only	ADV
dti-1378	271	37	one	one	NUM
dti-1378	271	38	residue	residue	NOUN
dti-1378	271	39	thr188	thr188	NOUN
dti-1378	271	40	.	.	PUNCT
dti-1378	272	1	the	the	DET
dti-1378	272	2	g3	g3	PROPN
dti-1378	272	3	box	box	NOUN
dti-1378	272	4	motif	motif	NOUN
dti-1378	272	5	(	(	PUNCT
dti-1378	272	6	black	black	ADJ
dti-1378	272	7	)	)	PUNCT
dti-1378	272	8	is	be	AUX
dti-1378	272	9	situated	situate	VERB
dti-1378	272	10	on	on	ADP
dti-1378	272	11	the	the	DET
dti-1378	272	12	loop	loop	NOUN
dti-1378	272	13	and	and	CCONJ
dti-1378	272	14	sheet	sheet	NOUN
dti-1378	272	15	;	;	PUNCT
dti-1378	272	16	g4	g4	NOUN
dti-1378	272	17	box	box	NOUN
dti-1378	272	18	motif	motif	NOUN
dti-1378	272	19	(	(	PUNCT
dti-1378	272	20	yellow	yellow	ADJ
dti-1378	272	21	)	)	PUNCT
dti-1378	272	22	on	on	ADP
dti-1378	272	23	the	the	DET
dti-1378	272	24	loop	loop	NOUN
dti-1378	272	25	,	,	PUNCT
dti-1378	272	26	helix	helix	NOUN
dti-1378	272	27	and	and	CCONJ
dti-1378	272	28	sheet	sheet	NOUN
dti-1378	272	29	and	and	CCONJ
dti-1378	272	30	g5	g5	NOUN
dti-1378	272	31	box	box	NOUN
dti-1378	272	32	motif	motif	NOUN
dti-1378	272	33	(	(	PUNCT
dti-1378	272	34	blue	blue	ADJ
dti-1378	272	35	)	)	PUNCT
dti-1378	272	36	is	be	AUX
dti-1378	272	37	located	locate	VERB
dti-1378	272	38	on	on	ADP
dti-1378	272	39	the	the	DET
dti-1378	272	40	loop	loop	NOUN
dti-1378	272	41	.	.	PUNCT
dti-1378	273	1	(	(	PUNCT
dti-1378	273	2	b	b	X
dti-1378	273	3	)	)	PUNCT
dti-1378	273	4	on	on	ADP
dti-1378	273	5	the	the	DET
dti-1378	273	6	folded	fold	VERB
dti-1378	273	7	structure	structure	NOUN
dti-1378	273	8	all	all	DET
dti-1378	273	9	five	five	NUM
dti-1378	273	10	g	g	NOUN
dti-1378	273	11	motifs	motif	NOUN
dti-1378	273	12	are	be	AUX
dti-1378	273	13	located	locate	VERB
dti-1378	273	14	in	in	ADP
dti-1378	273	15	the	the	DET
dti-1378	273	16	active	active	ADJ
dti-1378	273	17	site	site	NOUN
dti-1378	273	18	were	be	AUX
dti-1378	273	19	of	of	ADP
dti-1378	273	20	gtp	gtp	NOUN
dti-1378	273	21	binding	binding	NOUN
dti-1378	273	22	.	.	PUNCT
dti-1378	274	1	the	the	DET
dti-1378	274	2	g1	g1	PROPN
dti-1378	274	3	box	box	PROPN
dti-1378	274	4	motif	motif	NOUN
dti-1378	274	5	share	share	NOUN
dti-1378	274	6	residue	residue	NOUN
dti-1378	274	7	with	with	ADP
dti-1378	274	8	gtp	gtp	PROPN
dti-1378	274	9	/	/	SYM
dti-1378	274	10	mg2	mg2	PROPN
dti-1378	274	11	+	+	NOUN
dti-1378	274	12	ion	ion	NOUN
dti-1378	274	13	binding	bind	VERB
dti-1378	274	14	site	site	NOUN
dti-1378	274	15	,	,	PUNCT
dti-1378	274	16	g2	g2	PROPN
dti-1378	274	17	box	box	NOUN
dti-1378	274	18	motif	motif	NOUN
dti-1378	274	19	(	(	PUNCT
dti-1378	274	20	green	green	ADJ
dti-1378	274	21	)	)	PUNCT
dti-1378	274	22	share	share	NOUN
dti-1378	274	23	with	with	ADP
dti-1378	274	24	gtp	gtp	PROPN
dti-1378	274	25	/	/	SYM
dti-1378	274	26	mg2	mg2	PROPN
dti-1378	274	27	+	+	NOUN
dti-1378	274	28	ion	ion	NOUN
dti-1378	274	29	complex	complex	NOUN
dti-1378	274	30	and	and	CCONJ
dti-1378	274	31	the	the	DET
dti-1378	274	32	switch	switch	NOUN
dti-1378	274	33	1	1	NUM
dti-1378	274	34	,	,	PUNCT
dti-1378	274	35	g3	g3	PROPN
dti-1378	274	36	box	box	NOUN
dti-1378	274	37	motif	motif	NOUN
dti-1378	274	38	(	(	PUNCT
dti-1378	274	39	black	black	ADJ
dti-1378	274	40	)	)	PUNCT
dti-1378	274	41	shares	share	NOUN
dti-1378	274	42	with	with	ADP
dti-1378	274	43	mg2	mg2	PROPN
dti-1378	274	44	+	+	NOUN
dti-1378	274	45	ion	ion	NOUN
dti-1378	274	46	/	/	SYM
dti-1378	274	47	gtp	gtp	NOUN
dti-1378	274	48	complex	complex	NOUN
dti-1378	274	49	,	,	PUNCT
dti-1378	274	50	beta	beta	NOUN
dti-1378	274	51	-	-	PUNCT
dti-1378	274	52	gamma	gamma	NOUN
dti-1378	274	53	complex	complex	NOUN
dti-1378	274	54	,	,	PUNCT
dti-1378	274	55	goloco	goloco	ADJ
dti-1378	274	56	binding	bind	VERB
dti-1378	274	57	site	site	NOUN
dti-1378	274	58	and	and	CCONJ
dti-1378	274	59	the	the	DET
dti-1378	274	60	switch	switch	NOUN
dti-1378	274	61	2	2	NUM
dti-1378	274	62	region	region	NOUN
dti-1378	274	63	.	.	PUNCT
dti-1378	275	1	the	the	DET
dti-1378	275	2	g5	g5	PROPN
dti-1378	275	3	box	box	NOUN
dti-1378	275	4	motif	motif	NOUN
dti-1378	275	5	shares	share	NOUN
dti-1378	275	6	residue	residue	NOUN
dti-1378	275	7	(	(	PUNCT
dti-1378	275	8	ala351	ala351	NOUN
dti-1378	275	9	)	)	PUNCT
dti-1378	275	10	with	with	ADP
dti-1378	275	11	the	the	DET
dti-1378	275	12	gtp	gtp	PROPN
dti-1378	275	13	/	/	SYM
dti-1378	275	14	mg2	mg2	PROPN
dti-1378	275	15	+	+	NOUN
dti-1378	275	16	ion	ion	NOUN
dti-1378	275	17	binding	bind	VERB
dti-1378	275	18	site	site	NOUN
dti-1378	275	19	and	and	CCONJ
dti-1378	275	20	all	all	PRON
dti-1378	275	21	its	its	PRON
dti-1378	275	22	3	3	NUM
dti-1378	275	23	residues	residue	NOUN
dti-1378	275	24	with	with	ADP
dti-1378	275	25	the	the	DET
dti-1378	275	26	putative	putative	ADJ
dti-1378	275	27	receptor	receptor	NOUN
dti-1378	275	28	binding	bind	VERB
dti-1378	275	29	site	site	NOUN
dti-1378	275	30	.	.	PUNCT
dti-1378	276	1	the	the	DET
dti-1378	276	2	g2	g2	PROPN
dti-1378	276	3	box	box	NOUN
dti-1378	276	4	motif	motif	NOUN
dti-1378	276	5	(	(	PUNCT
dti-1378	276	6	green	green	ADJ
dti-1378	276	7	)	)	PUNCT
dti-1378	276	8	is	be	AUX
dti-1378	276	9	embedded	embed	VERB
dti-1378	276	10	in	in	ADP
dti-1378	276	11	the	the	DET
dti-1378	276	12	active	active	ADJ
dti-1378	276	13	cavity	cavity	NOUN
dti-1378	276	14	of	of	ADP
dti-1378	276	15	the	the	DET
dti-1378	276	16	protein	protein	NOUN
dti-1378	276	17	very	very	ADV
dti-1378	276	18	close	close	ADJ
dti-1378	276	19	to	to	ADP
dti-1378	276	20	g3	g3	NOUN
dti-1378	276	21	(	(	PUNCT
dti-1378	276	22	black	black	NOUN
dti-1378	276	23	)	)	PUNCT
dti-1378	276	24	with	with	ADP
dti-1378	276	25	g4	g4	NOUN
dti-1378	276	26	box	box	NOUN
dti-1378	276	27	motif	motif	NOUN
dti-1378	276	28	(	(	PUNCT
dti-1378	276	29	yellow	yellow	NOUN
dti-1378	276	30	)	)	PUNCT
dti-1378	276	31	situated	situate	VERB
dti-1378	276	32	very	very	ADV
dti-1378	276	33	close	close	ADV
dti-1378	276	34	to	to	ADP
dti-1378	276	35	g5	g5	VERB
dti-1378	276	36	box	box	NOUN
dti-1378	276	37	motif	motif	NOUN
dti-1378	276	38	(	(	PUNCT
dti-1378	276	39	blue	blue	ADJ
dti-1378	276	40	)	)	PUNCT
dti-1378	276	41	.	.	PUNCT
dti-1378	277	1	http://www.la-press.com	http://www.la-press.com	X
dti-1378	278	1	mbah	mbah	PROPN
dti-1378	278	2	et	et	PROPN
dti-1378	278	3	al	al	PROPN
dti-1378	278	4	52	52	NUM
dti-1378	278	5	drug	drug	NOUN
dti-1378	278	6	target	target	NOUN
dti-1378	278	7	insights	insight	NOUN
dti-1378	278	8	2012:6	2012:6	NUM
dti-1378	278	9	binding	bind	VERB
dti-1378	278	10	site	site	NOUN
dti-1378	278	11	,	,	PUNCT
dti-1378	278	12	and	and	CCONJ
dti-1378	278	13	all	all	PRON
dti-1378	278	14	have	have	VERB
dti-1378	278	15	well	well	ADV
dti-1378	278	16	-	-	PUNCT
dti-1378	278	17	conserved	conserve	VERB
dti-1378	278	18	elements	element	NOUN
dti-1378	278	19	in	in	ADP
dti-1378	278	20	their	their	PRON
dti-1378	278	21	domain	domain	NOUN
dti-1378	278	22	.	.	PUNCT
dti-1378	279	1	they	they	PRON
dti-1378	279	2	are	be	AUX
dti-1378	279	3	used	use	VERB
dti-1378	279	4	for	for	ADP
dti-1378	279	5	defining	define	VERB
dti-1378	279	6	the	the	DET
dti-1378	279	7	g	g	NOUN
dti-1378	279	8	protein	protein	NOUN
dti-1378	279	9	superfamily	superfamily	ADV
dti-1378	279	10	.	.	PUNCT
dti-1378	280	1	these	these	DET
dti-1378	280	2	loops	loop	NOUN
dti-1378	280	3	are	be	AUX
dti-1378	280	4	labeled	label	VERB
dti-1378	280	5	g1	g1	PROPN
dti-1378	280	6	box	box	NOUN
dti-1378	280	7	-	-	PUNCT
dti-1378	280	8	g5	g5	NOUN
dti-1378	280	9	box.33	box.33	CCONJ
dti-1378	280	10	all	all	DET
dti-1378	280	11	five	five	NUM
dti-1378	280	12	loops	loop	NOUN
dti-1378	280	13	were	be	AUX
dti-1378	280	14	present	present	ADJ
dti-1378	280	15	in	in	ADP
dti-1378	280	16	this	this	DET
dti-1378	280	17	protein	protein	NOUN
dti-1378	280	18	structural	structural	ADJ
dti-1378	280	19	view	view	NOUN
dti-1378	280	20	(	(	PUNCT
dti-1378	280	21	fig	fig	NOUN
dti-1378	280	22	.	.	PUNCT
dti-1378	280	23	11a	11a	NOUN
dti-1378	280	24	)	)	PUNCT
dti-1378	280	25	.	.	PUNCT
dti-1378	281	1	the	the	DET
dti-1378	281	2	g1	g1	PROPN
dti-1378	281	3	box	box	NOUN
dti-1378	281	4	motif	motif	NOUN
dti-1378	281	5	(	(	PUNCT
dti-1378	281	6	gxxxxgk(s	gxxxxgk(s	NOUN
dti-1378	281	7	/	/	SYM
dti-1378	281	8	k	k	NOUN
dti-1378	281	9	)	)	PUNCT
dti-1378	281	10	;	;	PUNCT
dti-1378	281	11	red	red	ADJ
dti-1378	281	12	)	)	PUNCT
dti-1378	281	13	has	have	AUX
dti-1378	281	14	been	be	AUX
dti-1378	281	15	mentioned	mention	VERB
dti-1378	281	16	above	above	ADV
dti-1378	281	17	in	in	ADP
dti-1378	281	18	connection	connection	NOUN
dti-1378	281	19	with	with	ADP
dti-1378	281	20	the	the	DET
dti-1378	281	21	gtp	gtp	PROPN
dti-1378	281	22	/	/	SYM
dti-1378	281	23	mg2	mg2	PROPN
dti-1378	281	24	+	+	NOUN
dti-1378	281	25	ion	ion	NOUN
dti-1378	281	26	binding	bind	VERB
dti-1378	281	27	site	site	NOUN
dti-1378	281	28	,	,	PUNCT
dti-1378	281	29	and	and	CCONJ
dti-1378	281	30	it	it	PRON
dti-1378	281	31	is	be	AUX
dti-1378	281	32	located	locate	VERB
dti-1378	281	33	on	on	ADP
dti-1378	281	34	the	the	DET
dti-1378	281	35	loop	loop	NOUN
dti-1378	281	36	,	,	PUNCT
dti-1378	281	37	sheet	sheet	NOUN
dti-1378	281	38	and	and	CCONJ
dti-1378	281	39	helix	helix	NOUN
dti-1378	281	40	(	(	PUNCT
dti-1378	281	41	fig	fig	NOUN
dti-1378	281	42	.	.	PUNCT
dti-1378	281	43	11a	11a	NOUN
dti-1378	281	44	)	)	PUNCT
dti-1378	281	45	.	.	PUNCT
dti-1378	282	1	it	it	PRON
dti-1378	282	2	is	be	AUX
dti-1378	282	3	used	use	VERB
dti-1378	282	4	for	for	ADP
dti-1378	282	5	defining	define	VERB
dti-1378	282	6	gtp	gtp	NOUN
dti-1378	282	7	binding	bind	VERB
dti-1378	282	8	proteins	protein	NOUN
dti-1378	282	9	in	in	ADP
dti-1378	282	10	general.33	general.33	PROPN
dti-1378	282	11	the	the	DET
dti-1378	282	12	g2	g2	PROPN
dti-1378	282	13	box	box	PROPN
dti-1378	282	14	motif	motif	NOUN
dti-1378	282	15	(	(	PUNCT
dti-1378	282	16	green	green	ADJ
dti-1378	282	17	)	)	PUNCT
dti-1378	282	18	is	be	AUX
dti-1378	282	19	located	locate	VERB
dti-1378	282	20	on	on	ADP
dti-1378	282	21	the	the	DET
dti-1378	282	22	loop	loop	NOUN
dti-1378	282	23	and	and	CCONJ
dti-1378	282	24	contains	contain	VERB
dti-1378	282	25	only	only	ADV
dti-1378	282	26	one	one	NUM
dti-1378	282	27	residue	residue	NOUN
dti-1378	282	28	,	,	PUNCT
dti-1378	282	29	being	be	AUX
dti-1378	282	30	thr188	thr188	NOUN
dti-1378	282	31	.	.	PUNCT
dti-1378	283	1	only	only	ADV
dti-1378	283	2	the	the	DET
dti-1378	283	3	thr188	thr188	NOUN
dti-1378	283	4	is	be	AUX
dti-1378	283	5	conserved	conserve	VERB
dti-1378	283	6	throughout	throughout	ADP
dti-1378	283	7	the	the	DET
dti-1378	283	8	superfamily	superfamily	NOUN
dti-1378	283	9	,	,	PUNCT
dti-1378	283	10	but	but	CCONJ
dti-1378	283	11	surrounding	surround	VERB
dti-1378	283	12	residues	residue	NOUN
dti-1378	283	13	are	be	AUX
dti-1378	283	14	conserved	conserve	VERB
dti-1378	283	15	within	within	ADP
dti-1378	283	16	the	the	DET
dti-1378	283	17	families	family	NOUN
dti-1378	283	18	.	.	PUNCT
dti-1378	284	1	the	the	DET
dti-1378	284	2	g2	g2	PROPN
dti-1378	284	3	box	box	PROPN
dti-1378	284	4	motif	motif	NOUN
dti-1378	284	5	is	be	AUX
dti-1378	284	6	part	part	NOUN
dti-1378	284	7	of	of	ADP
dti-1378	284	8	gtp	gtp	PROPN
dti-1378	284	9	/	/	SYM
dti-1378	284	10	mg2	mg2	PROPN
dti-1378	284	11	+	+	NOUN
dti-1378	284	12	ion	ion	NOUN
dti-1378	284	13	complex	complex	NOUN
dti-1378	284	14	and	and	CCONJ
dti-1378	284	15	switch	switch	VERB
dti-1378	284	16	i	i	PROPN
dti-1378	284	17	region	region	NOUN
dti-1378	284	18	.	.	PUNCT
dti-1378	285	1	the	the	DET
dti-1378	285	2	g3	g3	PROPN
dti-1378	285	3	box	box	NOUN
dti-1378	285	4	motif	motif	NOUN
dti-1378	285	5	(	(	PUNCT
dti-1378	285	6	black	black	NOUN
dti-1378	285	7	)	)	PUNCT
dti-1378	285	8	is	be	AUX
dti-1378	285	9	also	also	ADV
dti-1378	285	10	known	know	VERB
dti-1378	285	11	as	as	ADP
dti-1378	285	12	the	the	DET
dti-1378	285	13	dxxg	dxxg	NOUN
dti-1378	285	14	consensus	consensus	NOUN
dti-1378	285	15	sequence34–36	sequence34–36	PUNCT
dti-1378	285	16	and	and	CCONJ
dti-1378	285	17	is	be	AUX
dti-1378	285	18	situated	situate	VERB
dti-1378	285	19	on	on	ADP
dti-1378	285	20	the	the	DET
dti-1378	285	21	loop	loop	NOUN
dti-1378	285	22	and	and	CCONJ
dti-1378	285	23	sheet	sheet	NOUN
dti-1378	285	24	,	,	PUNCT
dti-1378	285	25	which	which	PRON
dti-1378	285	26	function	function	VERB
dti-1378	285	27	to	to	PART
dti-1378	285	28	link	link	VERB
dti-1378	285	29	the	the	DET
dti-1378	285	30	sub	sub	NOUN
dti-1378	285	31	-	-	NOUN
dti-1378	285	32	sites	site	NOUN
dti-1378	285	33	for	for	ADP
dti-1378	285	34	binding	bind	VERB
dti-1378	285	35	the	the	DET
dti-1378	285	36	mg2	mg2	NOUN
dti-1378	285	37	+	+	NOUN
dti-1378	285	38	ion	ion	NOUN
dti-1378	285	39	with	with	ADP
dti-1378	285	40	the	the	DET
dti-1378	285	41	γ	γ	X
dti-1378	285	42	phosphate	phosphate	NOUN
dti-1378	285	43	of	of	ADP
dti-1378	285	44	the	the	PRON
dti-1378	285	45	of	of	ADP
dti-1378	285	46	gtp	gtp	NOUN
dti-1378	285	47	.	.	PUNCT
dti-1378	286	1	it	it	PRON
dti-1378	286	2	also	also	ADV
dti-1378	286	3	shares	share	VERB
dti-1378	286	4	some	some	DET
dti-1378	286	5	common	common	ADJ
dti-1378	286	6	conserved	conserve	VERB
dti-1378	286	7	residues	residue	NOUN
dti-1378	286	8	with	with	ADP
dti-1378	286	9	the	the	DET
dti-1378	286	10	gtp	gtp	PROPN
dti-1378	286	11	/	/	SYM
dti-1378	286	12	mg2	mg2	PROPN
dti-1378	286	13	+	+	NOUN
dti-1378	286	14	ion	ion	NOUN
dti-1378	286	15	complex	complex	NOUN
dti-1378	286	16	,	,	PUNCT
dti-1378	286	17	betagamma	betagamma	PROPN
dti-1378	286	18	complex	complex	NOUN
dti-1378	286	19	,	,	PUNCT
dti-1378	286	20	goloco	goloco	ADJ
dti-1378	286	21	binding	bind	VERB
dti-1378	286	22	site	site	NOUN
dti-1378	286	23	and	and	CCONJ
dti-1378	286	24	the	the	DET
dti-1378	286	25	switch	switch	NOUN
dti-1378	286	26	ii	ii	PROPN
dti-1378	286	27	region	region	NOUN
dti-1378	286	28	(	(	PUNCT
dti-1378	286	29	table	table	NOUN
dti-1378	286	30	1	1	NUM
dti-1378	286	31	)	)	PUNCT
dti-1378	286	32	as	as	SCONJ
dti-1378	286	33	mentioned	mention	VERB
dti-1378	286	34	above	above	ADV
dti-1378	286	35	.	.	PUNCT
dti-1378	287	1	the	the	DET
dti-1378	287	2	g3	g3	PROPN
dti-1378	287	3	box	box	PROPN
dti-1378	287	4	motif	motif	NOUN
dti-1378	287	5	is	be	AUX
dti-1378	287	6	also	also	ADV
dti-1378	287	7	known	know	VERB
dti-1378	287	8	as	as	ADP
dti-1378	287	9	the	the	DET
dti-1378	287	10	walker	walker	PROPN
dti-1378	287	11	b	b	PROPN
dti-1378	287	12	motif37	motif37	NOUN
dti-1378	287	13	and	and	CCONJ
dti-1378	287	14	forms	form	VERB
dti-1378	287	15	an	an	DET
dti-1378	287	16	integral	integral	ADJ
dti-1378	287	17	part	part	NOUN
dti-1378	287	18	of	of	ADP
dti-1378	287	19	the	the	DET
dti-1378	287	20	switch	switch	NOUN
dti-1378	287	21	ii	ii	PROPN
dti-1378	287	22	region	region	NOUN
dti-1378	287	23	.	.	PUNCT
dti-1378	288	1	the	the	DET
dti-1378	288	2	g4	g4	NOUN
dti-1378	288	3	box	box	NOUN
dti-1378	288	4	motif	motif	NOUN
dti-1378	288	5	(	(	PUNCT
dti-1378	288	6	nkxd	nkxd	NOUN
dti-1378	288	7	;	;	PUNCT
dti-1378	288	8	yellow	yellow	ADJ
dti-1378	288	9	)	)	PUNCT
dti-1378	288	10	is	be	AUX
dti-1378	288	11	localized	localize	VERB
dti-1378	288	12	on	on	ADP
dti-1378	288	13	the	the	DET
dti-1378	288	14	loop	loop	NOUN
dti-1378	288	15	,	,	PUNCT
dti-1378	288	16	helix	helix	NOUN
dti-1378	288	17	and	and	CCONJ
dti-1378	288	18	sheet	sheet	NOUN
dti-1378	288	19	.	.	PUNCT
dti-1378	289	1	the	the	DET
dti-1378	289	2	main	main	ADJ
dti-1378	289	3	function	function	NOUN
dti-1378	289	4	of	of	ADP
dti-1378	289	5	the	the	DET
dti-1378	289	6	g4	g4	NOUN
dti-1378	289	7	box	box	NOUN
dti-1378	289	8	motif	motif	NOUN
dti-1378	289	9	is	be	AUX
dti-1378	289	10	to	to	PART
dti-1378	289	11	recognize	recognize	VERB
dti-1378	289	12	the	the	DET
dti-1378	289	13	guanine	guanine	NOUN
dti-1378	289	14	ring	ring	NOUN
dti-1378	289	15	.	.	PUNCT
dti-1378	290	1	the	the	DET
dti-1378	290	2	g5	g5	PROPN
dti-1378	290	3	box	box	NOUN
dti-1378	290	4	motif	motif	NOUN
dti-1378	290	5	(	(	PUNCT
dti-1378	290	6	[	[	X
dti-1378	290	7	c	c	X
dti-1378	290	8	/	/	SYM
dti-1378	290	9	s]a[k	s]a[k	NOUN
dti-1378	290	10	/	/	SYM
dti-1378	290	11	l	l	NOUN
dti-1378	290	12	/	/	SYM
dti-1378	290	13	t	t	PROPN
dti-1378	290	14	]	]	PUNCT
dti-1378	290	15	;	;	PUNCT
dti-1378	290	16	blue	blue	ADJ
dti-1378	290	17	)	)	PUNCT
dti-1378	290	18	functions	function	NOUN
dti-1378	290	19	as	as	ADP
dti-1378	290	20	a	a	DET
dti-1378	290	21	booster	booster	NOUN
dti-1378	290	22	to	to	ADP
dti-1378	290	23	the	the	DET
dti-1378	290	24	guanine	guanine	NOUN
dti-1378	290	25	base	base	PROPN
dti-1378	290	26	recognition	recognition	NOUN
dti-1378	290	27	site	site	NOUN
dti-1378	290	28	.	.	PUNCT
dti-1378	291	1	it	it	PRON
dti-1378	291	2	shares	share	VERB
dti-1378	291	3	one	one	NUM
dti-1378	291	4	conserved	conserved	ADJ
dti-1378	291	5	residue	residue	NOUN
dti-1378	291	6	(	(	PUNCT
dti-1378	291	7	ala351	ala351	NOUN
dti-1378	291	8	)	)	PUNCT
dti-1378	291	9	with	with	ADP
dti-1378	291	10	the	the	DET
dti-1378	291	11	gtp	gtp	PROPN
dti-1378	291	12	/	/	SYM
dti-1378	291	13	mg2	mg2	PROPN
dti-1378	291	14	+	+	NOUN
dti-1378	291	15	ion	ion	NOUN
dti-1378	291	16	binding	bind	VERB
dti-1378	291	17	site	site	NOUN
dti-1378	291	18	and	and	CCONJ
dti-1378	291	19	all	all	DET
dti-1378	291	20	3	3	NUM
dti-1378	291	21	residues	residue	NOUN
dti-1378	291	22	with	with	ADP
dti-1378	291	23	the	the	DET
dti-1378	291	24	putative	putative	ADJ
dti-1378	291	25	receptor	receptor	NOUN
dti-1378	291	26	binding	bind	VERB
dti-1378	291	27	site	site	NOUN
dti-1378	291	28	.	.	PUNCT
dti-1378	292	1	hence	hence	ADV
dti-1378	292	2	,	,	PUNCT
dti-1378	292	3	it	it	PRON
dti-1378	292	4	is	be	AUX
dti-1378	292	5	part	part	NOUN
dti-1378	292	6	of	of	ADP
dti-1378	292	7	the	the	DET
dti-1378	292	8	putative	putative	ADJ
dti-1378	292	9	receptor	receptor	NOUN
dti-1378	292	10	binding	bind	VERB
dti-1378	292	11	site	site	NOUN
dti-1378	292	12	(	(	PUNCT
dti-1378	292	13	table	table	NOUN
dti-1378	292	14	4	4	NUM
dti-1378	292	15	)	)	PUNCT
dti-1378	292	16	.	.	PUNCT
dti-1378	293	1	the	the	DET
dti-1378	293	2	protein	protein	NOUN
dti-1378	293	3	folded	fold	VERB
dti-1378	293	4	structure	structure	NOUN
dti-1378	293	5	indicates	indicate	VERB
dti-1378	293	6	that	that	SCONJ
dti-1378	293	7	all	all	DET
dti-1378	293	8	five	five	NUM
dti-1378	293	9	loops	loop	NOUN
dti-1378	293	10	(	(	PUNCT
dti-1378	293	11	g1	g1	PROPN
dti-1378	293	12	box	box	NOUN
dti-1378	293	13	-	-	PUNCT
dti-1378	293	14	g5	g5	NOUN
dti-1378	293	15	box	box	NOUN
dti-1378	293	16	)	)	PUNCT
dti-1378	293	17	are	be	AUX
dti-1378	293	18	located	locate	VERB
dti-1378	293	19	in	in	ADP
dti-1378	293	20	the	the	DET
dti-1378	293	21	active	active	ADJ
dti-1378	293	22	fold	fold	NOUN
dti-1378	293	23	(	(	PUNCT
dti-1378	293	24	fig	fig	NOUN
dti-1378	293	25	.	.	PUNCT
dti-1378	293	26	11b	11b	NOUN
dti-1378	293	27	)	)	PUNCT
dti-1378	293	28	.	.	PUNCT
dti-1378	294	1	the	the	DET
dti-1378	294	2	g2	g2	PROPN
dti-1378	294	3	box	box	NOUN
dti-1378	294	4	motif	motif	NOUN
dti-1378	294	5	(	(	PUNCT
dti-1378	294	6	green	green	ADJ
dti-1378	294	7	)	)	PUNCT
dti-1378	294	8	is	be	AUX
dti-1378	294	9	embedded	embed	VERB
dti-1378	294	10	in	in	ADP
dti-1378	294	11	the	the	DET
dti-1378	294	12	active	active	ADJ
dti-1378	294	13	cavity	cavity	NOUN
dti-1378	294	14	of	of	ADP
dti-1378	294	15	the	the	DET
dti-1378	294	16	protein	protein	NOUN
dti-1378	294	17	,	,	PUNCT
dti-1378	294	18	very	very	ADV
dti-1378	294	19	close	close	ADJ
dti-1378	294	20	to	to	ADP
dti-1378	294	21	g3	g3	PROPN
dti-1378	294	22	box	box	NOUN
dti-1378	294	23	motif	motif	NOUN
dti-1378	294	24	(	(	PUNCT
dti-1378	294	25	black	black	NOUN
dti-1378	294	26	)	)	PUNCT
dti-1378	294	27	with	with	ADP
dti-1378	294	28	g4	g4	NOUN
dti-1378	294	29	box	box	NOUN
dti-1378	294	30	motif	motif	NOUN
dti-1378	294	31	(	(	PUNCT
dti-1378	294	32	yellow	yellow	NOUN
dti-1378	294	33	)	)	PUNCT
dti-1378	294	34	situated	situate	VERB
dti-1378	294	35	very	very	ADV
dti-1378	294	36	close	close	ADV
dti-1378	294	37	to	to	ADP
dti-1378	294	38	g5	g5	VERB
dti-1378	294	39	box	box	NOUN
dti-1378	294	40	motif	motif	NOUN
dti-1378	294	41	(	(	PUNCT
dti-1378	294	42	blue	blue	ADJ
dti-1378	294	43	)	)	PUNCT
dti-1378	294	44	.	.	PUNCT
dti-1378	295	1	ligand	ligand	NOUN
dti-1378	295	2	binding	bind	VERB
dti-1378	295	3	site	site	NOUN
dti-1378	295	4	the	the	DET
dti-1378	295	5	predicted	predict	VERB
dti-1378	295	6	ligand	ligand	NOUN
dti-1378	295	7	binding	bind	VERB
dti-1378	295	8	analysis	analysis	NOUN
dti-1378	295	9	shows	show	VERB
dti-1378	295	10	that	that	SCONJ
dti-1378	295	11	at	at	ADP
dti-1378	295	12	the	the	DET
dti-1378	295	13	gtp	gtp	PROPN
dti-1378	295	14	/	/	SYM
dti-1378	295	15	mg2	mg2	PROPN
dti-1378	295	16	+	+	NOUN
dti-1378	295	17	ion	ion	NOUN
dti-1378	295	18	complex	complex	NOUN
dti-1378	295	19	site	site	NOUN
dti-1378	295	20	,	,	PUNCT
dti-1378	295	21	the	the	DET
dti-1378	295	22	mg2	mg2	PROPN
dti-1378	295	23	+	+	NOUN
dti-1378	295	24	ion	ion	NOUN
dti-1378	295	25	binds	bind	VERB
dti-1378	295	26	to	to	PART
dti-1378	295	27	ser53	ser53	VERB
dti-1378	295	28	and	and	CCONJ
dti-1378	295	29	the	the	DET
dti-1378	295	30	metallic	metallic	ADJ
dti-1378	295	31	ligand	ligand	NOUN
dti-1378	295	32	is	be	AUX
dti-1378	295	33	well	well	ADV
dti-1378	295	34	embedded	embed	VERB
dti-1378	295	35	in	in	ADP
dti-1378	295	36	the	the	DET
dti-1378	295	37	active	active	ADJ
dti-1378	295	38	cavity	cavity	NOUN
dti-1378	295	39	(	(	PUNCT
dti-1378	295	40	fig	fig	NOUN
dti-1378	295	41	.	.	PUNCT
dti-1378	295	42	12	12	NUM
dti-1378	295	43	)	)	PUNCT
dti-1378	295	44	.	.	PUNCT
dti-1378	296	1	this	this	DET
dti-1378	296	2	ligand	ligand	NOUN
dti-1378	296	3	binding	binding	NOUN
dti-1378	296	4	indicates	indicate	VERB
dti-1378	296	5	that	that	SCONJ
dti-1378	296	6	irrespective	irrespective	ADV
dti-1378	296	7	of	of	ADP
dti-1378	296	8	the	the	DET
dti-1378	296	9	residues	residue	NOUN
dti-1378	296	10	coordinating	coordinate	VERB
dti-1378	296	11	the	the	DET
dti-1378	296	12	gtp	gtp	NOUN
dti-1378	296	13	binding	bind	VERB
dti-1378	296	14	at	at	ADP
dti-1378	296	15	gtp	gtp	PROPN
dti-1378	296	16	/	/	SYM
dti-1378	296	17	mg2	mg2	PROPN
dti-1378	296	18	+	+	NOUN
dti-1378	296	19	ion	ion	NOUN
dti-1378	296	20	complex	complex	NOUN
dti-1378	296	21	site	site	NOUN
dti-1378	296	22	,	,	PUNCT
dti-1378	296	23	ser53	ser53	PROPN
dti-1378	296	24	could	could	AUX
dti-1378	296	25	be	be	AUX
dti-1378	296	26	considered	consider	VERB
dti-1378	296	27	crucial	crucial	ADJ
dti-1378	296	28	in	in	ADP
dti-1378	296	29	regulating	regulate	VERB
dti-1378	296	30	the	the	DET
dti-1378	296	31	adenylyl	adenylyl	NOUN
dti-1378	296	32	cyclase	cyclase	NOUN
dti-1378	296	33	pathway	pathway	NOUN
dti-1378	296	34	in	in	ADP
dti-1378	296	35	s.	s.	PROPN
dti-1378	296	36	mansoni	mansoni	ADJ
dti-1378	296	37	developmental	developmental	ADJ
dti-1378	296	38	cycles	cycle	NOUN
dti-1378	296	39	.	.	PUNCT
dti-1378	297	1	discussion	discussion	NOUN
dti-1378	297	2	physicochemical	physicochemical	ADJ
dti-1378	297	3	properties	property	NOUN
dti-1378	297	4	of	of	ADP
dti-1378	297	5	the	the	DET
dti-1378	297	6	s.	s.	PROPN
dti-1378	297	7	mansoni	mansoni	PROPN
dti-1378	297	8	smp_059340.1	smp_059340.1	PROPN
dti-1378	297	9	protein	protein	NOUN
dti-1378	297	10	the	the	DET
dti-1378	297	11	smp_059340.1	smp_059340.1	PROPN
dti-1378	297	12	protein	protein	NOUN
dti-1378	297	13	regulating	regulate	VERB
dti-1378	297	14	adenylyl	adenylyl	NOUN
dti-1378	297	15	cyclase	cyclase	NOUN
dti-1378	297	16	pathway	pathway	NOUN
dti-1378	297	17	in	in	ADP
dti-1378	297	18	schistosoma	schistosoma	ADJ
dti-1378	297	19	mansoni	mansoni	ADJ
dti-1378	297	20	development	development	NOUN
dti-1378	297	21	can	can	AUX
dti-1378	297	22	be	be	AUX
dti-1378	297	23	described	describe	VERB
dti-1378	297	24	as	as	ADP
dti-1378	297	25	moderately	moderately	ADV
dti-1378	297	26	hydrophilic	hydrophilic	ADJ
dti-1378	297	27	and	and	CCONJ
dti-1378	297	28	basic	basic	ADJ
dti-1378	297	29	in	in	ADP
dti-1378	297	30	nature	nature	NOUN
dti-1378	297	31	(	(	PUNCT
dti-1378	297	32	table	table	NOUN
dti-1378	297	33	1	1	NUM
dti-1378	297	34	)	)	PUNCT
dti-1378	297	35	.	.	PUNCT
dti-1378	298	1	the	the	DET
dti-1378	298	2	hydrophobic	hydrophobic	NOUN
dti-1378	298	3	residues	residue	NOUN
dti-1378	298	4	are	be	AUX
dti-1378	298	5	usually	usually	ADV
dti-1378	298	6	found	find	VERB
dti-1378	298	7	in	in	ADP
dti-1378	298	8	the	the	DET
dti-1378	298	9	core	core	NOUN
dti-1378	298	10	of	of	ADP
dti-1378	298	11	most	most	ADJ
dti-1378	298	12	proteins	protein	NOUN
dti-1378	298	13	and	and	CCONJ
dti-1378	298	14	they	they	PRON
dti-1378	298	15	help	help	VERB
dti-1378	298	16	stabilize	stabilize	VERB
dti-1378	298	17	the	the	DET
dti-1378	298	18	proteins	protein	NOUN
dti-1378	298	19	during	during	ADP
dti-1378	298	20	their	their	PRON
dti-1378	298	21	numerous	numerous	ADJ
dti-1378	298	22	van	van	PROPN
dti-1378	298	23	der	der	PROPN
dti-1378	298	24	waal	waal	PROPN
dti-1378	298	25	interactions.38	interactions.38	PROPN
dti-1378	298	26	the	the	DET
dti-1378	298	27	hydrophilic	hydrophilic	ADJ
dti-1378	298	28	residues	residue	NOUN
dti-1378	298	29	are	be	AUX
dti-1378	298	30	located	locate	VERB
dti-1378	298	31	mostly	mostly	ADV
dti-1378	298	32	at	at	ADP
dti-1378	298	33	the	the	DET
dti-1378	298	34	surface	surface	NOUN
dti-1378	298	35	active	active	ADJ
dti-1378	298	36	sites	site	NOUN
dti-1378	298	37	of	of	ADP
dti-1378	298	38	the	the	DET
dti-1378	298	39	proteins	protein	NOUN
dti-1378	298	40	,	,	PUNCT
dti-1378	298	41	where	where	SCONJ
dti-1378	298	42	they	they	PRON
dti-1378	298	43	interact	interact	VERB
dti-1378	298	44	with	with	ADP
dti-1378	298	45	other	other	ADJ
dti-1378	298	46	polar	polar	ADJ
dti-1378	298	47	residues	residue	NOUN
dti-1378	298	48	in	in	ADP
dti-1378	298	49	the	the	DET
dti-1378	298	50	protein	protein	NOUN
dti-1378	298	51	or	or	CCONJ
dti-1378	298	52	with	with	ADP
dti-1378	298	53	water	water	NOUN
dti-1378	298	54	molecules	molecule	NOUN
dti-1378	298	55	.	.	PUNCT
dti-1378	299	1	the	the	DET
dti-1378	299	2	pi	pi	NOUN
dti-1378	299	3	indicates	indicate	VERB
dti-1378	299	4	the	the	DET
dti-1378	299	5	ph	ph	NOUN
dti-1378	299	6	at	at	ADP
dti-1378	299	7	which	which	PRON
dti-1378	299	8	the	the	DET
dti-1378	299	9	protein	protein	NOUN
dti-1378	299	10	surface	surface	NOUN
dti-1378	299	11	is	be	AUX
dti-1378	299	12	covered	cover	VERB
dti-1378	299	13	with	with	ADP
dti-1378	299	14	charge,39	charge,39	NOUN
dti-1378	299	15	and	and	CCONJ
dti-1378	299	16	the	the	DET
dti-1378	299	17	net	net	ADJ
dti-1378	299	18	charge	charge	NOUN
dti-1378	299	19	of	of	ADP
dti-1378	299	20	smp_059340.1	smp_059340.1	PROPN
dti-1378	299	21	is	be	AUX
dti-1378	299	22	positive	positive	ADJ
dti-1378	299	23	.	.	PUNCT
dti-1378	300	1	the	the	DET
dti-1378	300	2	high	high	ADJ
dti-1378	300	3	number	number	NOUN
dti-1378	300	4	of	of	ADP
dti-1378	300	5	positive	positive	ADJ
dti-1378	300	6	charged	charge	VERB
dti-1378	300	7	residues	residue	NOUN
dti-1378	300	8	(	(	PUNCT
dti-1378	300	9	arg	arg	NOUN
dti-1378	300	10	+	+	NUM
dti-1378	300	11	lys	lys	NOUN
dti-1378	300	12	=	=	SYM
dti-1378	300	13	58	58	NUM
dti-1378	300	14	)	)	PUNCT
dti-1378	300	15	against	against	ADP
dti-1378	300	16	the	the	DET
dti-1378	300	17	total	total	ADJ
dti-1378	300	18	number	number	NOUN
dti-1378	300	19	of	of	ADP
dti-1378	300	20	negatively	negatively	ADV
dti-1378	300	21	charged	charge	VERB
dti-1378	300	22	residues	residue	NOUN
dti-1378	300	23	(	(	PUNCT
dti-1378	300	24	asp	asp	NOUN
dti-1378	300	25	+	+	CCONJ
dti-1378	300	26	glu	glu	NOUN
dti-1378	300	27	=	=	SYM
dti-1378	300	28	53	53	NUM
dti-1378	300	29	)	)	PUNCT
dti-1378	300	30	is	be	AUX
dti-1378	300	31	the	the	DET
dti-1378	300	32	main	main	ADJ
dti-1378	300	33	contributing	contribute	VERB
dti-1378	300	34	factor	factor	NOUN
dti-1378	300	35	to	to	ADP
dti-1378	300	36	the	the	DET
dti-1378	300	37	positive	positive	ADJ
dti-1378	300	38	charge	charge	NOUN
dti-1378	300	39	.	.	PUNCT
dti-1378	301	1	pi	pi	ADJ
dti-1378	301	2	proteins	protein	NOUN
dti-1378	301	3	are	be	AUX
dti-1378	301	4	generally	generally	ADV
dti-1378	301	5	stable	stable	ADJ
dti-1378	301	6	and	and	CCONJ
dti-1378	301	7	compact	compact	ADJ
dti-1378	301	8	,	,	PUNCT
dti-1378	301	9	thus	thus	ADV
dti-1378	301	10	this	this	DET
dti-1378	301	11	parameter	parameter	NOUN
dti-1378	301	12	will	will	AUX
dti-1378	301	13	be	be	AUX
dti-1378	301	14	useful	useful	ADJ
dti-1378	301	15	for	for	ADP
dti-1378	301	16	developing	develop	VERB
dti-1378	301	17	buffer	buffer	NOUN
dti-1378	301	18	systems	system	NOUN
dti-1378	301	19	for	for	ADP
dti-1378	301	20	purification	purification	NOUN
dti-1378	301	21	of	of	ADP
dti-1378	301	22	this	this	DET
dti-1378	301	23	protein	protein	NOUN
dti-1378	301	24	by	by	ADP
dti-1378	301	25	isoelectric	isoelectric	ADJ
dti-1378	301	26	focusing	focus	VERB
dti-1378	301	27	techniques.39	techniques.39	NOUN
dti-1378	301	28	the	the	DET
dti-1378	301	29	high	high	ADJ
dti-1378	301	30	extinction	extinction	NOUN
dti-1378	301	31	coefficient	coefficient	NOUN
dti-1378	301	32	of	of	ADP
dti-1378	301	33	43485	43485	NUM
dti-1378	301	34	m−1	m−1	PROPN
dti-1378	301	35	cm−1	cm−1	NOUN
dti-1378	301	36	at	at	ADP
dti-1378	301	37	280	280	NUM
dti-1378	301	38	nm	nm	ADJ
dti-1378	301	39	wavelength	wavelength	NOUN
dti-1378	301	40	computed	compute	VERB
dti-1378	301	41	for	for	ADP
dti-1378	301	42	smp_059340.1	smp_059340.1	PROPN
dti-1378	301	43	was	be	AUX
dti-1378	301	44	due	due	ADJ
dti-1378	301	45	to	to	ADP
dti-1378	301	46	the	the	DET
dti-1378	301	47	individual	individual	ADJ
dti-1378	301	48	contributions	contribution	NOUN
dti-1378	301	49	of	of	ADP
dti-1378	301	50	cys	cys	PROPN
dti-1378	301	51	(	(	PUNCT
dti-1378	301	52	2.9	2.9	NUM
dti-1378	301	53	%	%	NOUN
dti-1378	301	54	)	)	PUNCT
dti-1378	301	55	,	,	PUNCT
dti-1378	301	56	trp	trp	PROPN
dti-1378	301	57	(	(	PUNCT
dti-1378	301	58	1.1	1.1	NUM
dti-1378	301	59	%	%	NOUN
dti-1378	301	60	)	)	PUNCT
dti-1378	301	61	and	and	CCONJ
dti-1378	301	62	tyr	tyr	X
dti-1378	301	63	(	(	PUNCT
dti-1378	301	64	3.7	3.7	NUM
dti-1378	301	65	%	%	NOUN
dti-1378	301	66	)	)	PUNCT
dti-1378	301	67	concentrations	concentration	NOUN
dti-1378	301	68	respectively	respectively	ADV
dti-1378	301	69	.	.	PUNCT
dti-1378	302	1	this	this	DET
dti-1378	302	2	observation	observation	NOUN
dti-1378	302	3	suggests	suggest	VERB
dti-1378	302	4	that	that	SCONJ
dti-1378	302	5	the	the	DET
dti-1378	302	6	smp_059340.1	smp_059340.1	PROPN
dti-1378	302	7	figure	figure	NOUN
dti-1378	302	8	12	12	NUM
dti-1378	302	9	.	.	PUNCT
dti-1378	303	1	binding	bind	VERB
dti-1378	303	2	of	of	ADP
dti-1378	303	3	mg2	mg2	PROPN
dti-1378	303	4	+	+	PROPN
dti-1378	303	5	ion	ion	NOUN
dti-1378	303	6	on	on	ADP
dti-1378	303	7	schistosoma	schistosoma	ADJ
dti-1378	303	8	mansoni	mansoni	ADJ
dti-1378	303	9	smp_059340.1	smp_059340.1	PROPN
dti-1378	303	10	gtp	gtp	PROPN
dti-1378	303	11	/	/	SYM
dti-1378	303	12	mg2	mg2	PROPN
dti-1378	303	13	+	+	NOUN
dti-1378	303	14	ion	ion	NOUN
dti-1378	303	15	complex	complex	NOUN
dti-1378	303	16	site	site	NOUN
dti-1378	303	17	.	.	PUNCT
dti-1378	304	1	(	(	PUNCT
dti-1378	304	2	a	a	X
dti-1378	304	3	)	)	PUNCT
dti-1378	304	4	the	the	DET
dti-1378	304	5	binding	binding	NOUN
dti-1378	304	6	of	of	ADP
dti-1378	304	7	mg2	mg2	PROPN
dti-1378	304	8	+	+	PROPN
dti-1378	304	9	ions	ion	NOUN
dti-1378	304	10	on	on	ADP
dti-1378	304	11	the	the	DET
dti-1378	304	12	secondary	secondary	ADJ
dti-1378	304	13	structure	structure	NOUN
dti-1378	304	14	with	with	ADP
dti-1378	304	15	only	only	ADJ
dti-1378	304	16	ser53	ser53	PROPN
dti-1378	304	17	(	(	PUNCT
dti-1378	304	18	blue	blue	ADJ
dti-1378	304	19	)	)	PUNCT
dti-1378	304	20	located	locate	VERB
dti-1378	304	21	on	on	ADP
dti-1378	304	22	the	the	DET
dti-1378	304	23	helix	helix	NOUN
dti-1378	304	24	is	be	AUX
dti-1378	304	25	involved	involve	VERB
dti-1378	304	26	in	in	ADP
dti-1378	304	27	binding	bind	VERB
dti-1378	304	28	.	.	PUNCT
dti-1378	305	1	(	(	PUNCT
dti-1378	305	2	b	b	X
dti-1378	305	3	)	)	PUNCT
dti-1378	305	4	the	the	DET
dti-1378	305	5	mg2	mg2	PROPN
dti-1378	305	6	+	+	NOUN
dti-1378	305	7	ion	ion	NOUN
dti-1378	305	8	is	be	AUX
dti-1378	305	9	embedded	embed	VERB
dti-1378	305	10	deeper	deeply	ADV
dti-1378	305	11	in	in	ADP
dti-1378	305	12	the	the	DET
dti-1378	305	13	cavity	cavity	NOUN
dti-1378	305	14	binding	bind	VERB
dti-1378	305	15	with	with	ADP
dti-1378	305	16	ser53	ser53	NOUN
dti-1378	305	17	and	and	CCONJ
dti-1378	305	18	regulated	regulate	VERB
dti-1378	305	19	by	by	ADP
dti-1378	305	20	the	the	DET
dti-1378	305	21	g	g	PROPN
dti-1378	305	22	box	box	NOUN
dti-1378	305	23	motifs	motifs	NOUN
dti-1378	305	24	(	(	PUNCT
dti-1378	305	25	fig	fig	NOUN
dti-1378	305	26	.	.	PUNCT
dti-1378	306	1	11	11	NUM
dti-1378	306	2	)	)	PUNCT
dti-1378	307	1	and	and	CCONJ
dti-1378	307	2	other	other	ADJ
dti-1378	307	3	domains	domain	NOUN
dti-1378	307	4	sharing	share	VERB
dti-1378	307	5	residues	residue	NOUN
dti-1378	307	6	with	with	ADP
dti-1378	307	7	gtp	gtp	PROPN
dti-1378	307	8	/	/	SYM
dti-1378	307	9	mg2	mg2	PROPN
dti-1378	307	10	+	+	NOUN
dti-1378	307	11	ion	ion	NOUN
dti-1378	307	12	complex	complex	NOUN
dti-1378	307	13	site	site	NOUN
dti-1378	307	14	.	.	PUNCT
dti-1378	308	1	http://www.la-press.com	http://www.la-press.com	X
dti-1378	308	2	drug	drug	NOUN
dti-1378	308	3	target	target	NOUN
dti-1378	308	4	features	feature	NOUN
dti-1378	308	5	of	of	ADP
dti-1378	308	6	schistosoma	schistosoma	ADJ
dti-1378	308	7	adenylyl	adenylyl	NOUN
dti-1378	308	8	cyclase	cyclase	NOUN
dti-1378	308	9	activity	activity	NOUN
dti-1378	308	10	drug	drug	NOUN
dti-1378	308	11	target	target	NOUN
dti-1378	308	12	insights	insight	NOUN
dti-1378	308	13	2012:6	2012:6	NUM
dti-1378	308	14	53	53	NUM
dti-1378	308	15	protein	protein	NOUN
dti-1378	308	16	can	can	AUX
dti-1378	308	17	be	be	AUX
dti-1378	308	18	analyzed	analyze	VERB
dti-1378	308	19	using	use	VERB
dti-1378	308	20	a	a	DET
dti-1378	308	21	uv	uv	NOUN
dti-1378	308	22	spectrum	spectrum	NOUN
dti-1378	308	23	assay	assay	PROPN
dti-1378	308	24	protocol.40	protocol.40	PROPN
dti-1378	308	25	the	the	DET
dti-1378	308	26	computed	compute	VERB
dti-1378	308	27	protein	protein	NOUN
dti-1378	308	28	concentration	concentration	NOUN
dti-1378	308	29	and	and	CCONJ
dti-1378	308	30	the	the	DET
dti-1378	308	31	extinction	extinction	NOUN
dti-1378	308	32	coefficient	coefficient	NOUN
dti-1378	308	33	could	could	AUX
dti-1378	308	34	be	be	AUX
dti-1378	308	35	important	important	ADJ
dti-1378	308	36	in	in	ADP
dti-1378	308	37	the	the	DET
dti-1378	308	38	quantitative	quantitative	ADJ
dti-1378	308	39	analysis	analysis	NOUN
dti-1378	308	40	of	of	ADP
dti-1378	308	41	the	the	DET
dti-1378	308	42	protein	protein	NOUN
dti-1378	308	43	-	-	PUNCT
dti-1378	308	44	protein	protein	NOUN
dti-1378	308	45	and	and	CCONJ
dti-1378	308	46	protein	protein	NOUN
dti-1378	308	47	-	-	PUNCT
dti-1378	308	48	ligand	ligand	NOUN
dti-1378	308	49	interactions	interaction	NOUN
dti-1378	308	50	of	of	ADP
dti-1378	308	51	this	this	DET
dti-1378	308	52	protein	protein	NOUN
dti-1378	308	53	in	in	ADP
dti-1378	308	54	solutions.40,41	solutions.40,41	NOUN
dti-1378	308	55	the	the	DET
dti-1378	308	56	estimated	estimate	VERB
dti-1378	308	57	half	half	ADJ
dti-1378	308	58	-	-	PUNCT
dti-1378	308	59	life	life	NOUN
dti-1378	308	60	of	of	ADP
dti-1378	308	61	this	this	DET
dti-1378	308	62	protein	protein	NOUN
dti-1378	308	63	with	with	ADP
dti-1378	308	64	met	meet	VERB
dti-1378	308	65	as	as	ADP
dti-1378	308	66	the	the	DET
dti-1378	308	67	n	n	NOUN
dti-1378	308	68	-	-	PUNCT
dti-1378	308	69	terminal	terminal	NOUN
dti-1378	308	70	of	of	ADP
dti-1378	308	71	the	the	DET
dti-1378	308	72	sequence	sequence	NOUN
dti-1378	308	73	was	be	AUX
dti-1378	308	74	30	30	NUM
dti-1378	308	75	(	(	PUNCT
dti-1378	308	76	.20	.20	NUM
dti-1378	308	77	)	)	PUNCT
dti-1378	308	78	hours	hour	NOUN
dti-1378	308	79	.	.	PUNCT
dti-1378	309	1	the	the	DET
dti-1378	309	2	high	high	ADJ
dti-1378	309	3	concentrations	concentration	NOUN
dti-1378	309	4	of	of	ADP
dti-1378	309	5	ala	ala	PROPN
dti-1378	309	6	(	(	PUNCT
dti-1378	309	7	6.1	6.1	NUM
dti-1378	309	8	%	%	NOUN
dti-1378	309	9	)	)	PUNCT
dti-1378	309	10	,	,	PUNCT
dti-1378	309	11	leu	leu	PROPN
dti-1378	309	12	(	(	PUNCT
dti-1378	309	13	9.2	9.2	NUM
dti-1378	309	14	%	%	NOUN
dti-1378	309	15	)	)	PUNCT
dti-1378	309	16	and	and	CCONJ
dti-1378	309	17	val	val	NOUN
dti-1378	309	18	(	(	PUNCT
dti-1378	309	19	5.3	5.3	NUM
dti-1378	309	20	%	%	NOUN
dti-1378	309	21	)	)	PUNCT
dti-1378	309	22	may	may	AUX
dti-1378	309	23	be	be	AUX
dti-1378	309	24	contributing	contribute	VERB
dti-1378	309	25	to	to	ADP
dti-1378	309	26	the	the	DET
dti-1378	309	27	stability	stability	NOUN
dti-1378	309	28	of	of	ADP
dti-1378	309	29	this	this	PRON
dti-1378	309	30	protein.42,43	protein.42,43	VERB
dti-1378	309	31	the	the	DET
dti-1378	309	32	half	half	ADJ
dti-1378	309	33	-	-	PUNCT
dti-1378	309	34	life	life	NOUN
dti-1378	309	35	of	of	ADP
dti-1378	309	36	these	these	DET
dti-1378	309	37	3	3	NUM
dti-1378	309	38	residues	residue	NOUN
dti-1378	309	39	has	have	AUX
dti-1378	309	40	been	be	AUX
dti-1378	309	41	well	well	ADV
dti-1378	309	42	documented	document	VERB
dti-1378	309	43	in	in	ADP
dti-1378	309	44	mammals	mammal	NOUN
dti-1378	309	45	with	with	ADP
dti-1378	309	46	values	value	NOUN
dti-1378	309	47	of	of	ADP
dti-1378	309	48	ala	ala	PROPN
dti-1378	309	49	(	(	PUNCT
dti-1378	309	50	4.4	4.4	NUM
dti-1378	309	51	hours	hour	NOUN
dti-1378	309	52	)	)	PUNCT
dti-1378	309	53	,	,	PUNCT
dti-1378	309	54	leu	leu	PROPN
dti-1378	309	55	(	(	PUNCT
dti-1378	309	56	5.5	5.5	NUM
dti-1378	309	57	hours	hour	NOUN
dti-1378	309	58	)	)	PUNCT
dti-1378	309	59	and	and	CCONJ
dti-1378	309	60	val	val	NOUN
dti-1378	309	61	(	(	PUNCT
dti-1378	309	62	100	100	NUM
dti-1378	309	63	hours	hour	NOUN
dti-1378	309	64	)	)	PUNCT
dti-1378	309	65	.	.	PUNCT
dti-1378	310	1	in	in	ADP
dti-1378	310	2	other	other	ADJ
dti-1378	310	3	organisms	organism	NOUN
dti-1378	310	4	,	,	PUNCT
dti-1378	310	5	these	these	DET
dti-1378	310	6	residues	residue	NOUN
dti-1378	310	7	also	also	ADV
dti-1378	310	8	contribute	contribute	VERB
dti-1378	310	9	to	to	ADP
dti-1378	310	10	the	the	DET
dti-1378	310	11	protein	protein	NOUN
dti-1378	310	12	stability	stability	NOUN
dti-1378	310	13	.	.	PUNCT
dti-1378	311	1	in	in	ADP
dti-1378	311	2	yeast	yeast	NOUN
dti-1378	311	3	,	,	PUNCT
dti-1378	311	4	the	the	DET
dti-1378	311	5	half	half	ADJ
dti-1378	311	6	life	life	NOUN
dti-1378	311	7	was	be	AUX
dti-1378	311	8	the	the	DET
dti-1378	311	9	same	same	ADJ
dti-1378	311	10	(	(	PUNCT
dti-1378	311	11	.20	.20	NUM
dti-1378	311	12	hours	hour	NOUN
dti-1378	311	13	)	)	PUNCT
dti-1378	311	14	for	for	ADP
dti-1378	311	15	both	both	CCONJ
dti-1378	311	16	ala	ala	PROPN
dti-1378	311	17	and	and	CCONJ
dti-1378	311	18	val	val	NOUN
dti-1378	311	19	,	,	PUNCT
dti-1378	311	20	as	as	ADV
dti-1378	311	21	well	well	ADV
dti-1378	311	22	as	as	ADP
dti-1378	311	23	in	in	ADP
dti-1378	311	24	escherichia	escherichia	NOUN
dti-1378	311	25	coli	coli	NOUN
dti-1378	311	26	,	,	PUNCT
dti-1378	311	27	with	with	ADP
dti-1378	311	28	values	value	NOUN
dti-1378	311	29	.	.	PUNCT
dti-1378	312	1	10.44	10.44	NUM
dti-1378	312	2	the	the	DET
dti-1378	312	3	instability	instability	NOUN
dti-1378	312	4	index	index	NOUN
dti-1378	312	5	prediction	prediction	NOUN
dti-1378	312	6	using	use	VERB
dti-1378	312	7	the	the	DET
dti-1378	312	8	protparam	protparam	PROPN
dti-1378	312	9	tool	tool	NOUN
dti-1378	312	10	indicates	indicate	VERB
dti-1378	312	11	that	that	SCONJ
dti-1378	312	12	smp_059340.1	smp_059340.1	PROPN
dti-1378	312	13	may	may	AUX
dti-1378	312	14	be	be	AUX
dti-1378	312	15	unstable	unstable	ADJ
dti-1378	312	16	with	with	ADP
dti-1378	312	17	a	a	DET
dti-1378	312	18	value	value	NOUN
dti-1378	312	19	of	of	ADP
dti-1378	312	20	48.15	48.15	NUM
dti-1378	312	21	.	.	PUNCT
dti-1378	313	1	this	this	DET
dti-1378	313	2	parameter	parameter	NOUN
dti-1378	313	3	was	be	AUX
dti-1378	313	4	computed	compute	VERB
dti-1378	313	5	from	from	ADP
dti-1378	313	6	the	the	DET
dti-1378	313	7	impact	impact	NOUN
dti-1378	313	8	of	of	ADP
dti-1378	313	9	dipeptides	dipeptide	NOUN
dti-1378	313	10	in	in	ADP
dti-1378	313	11	the	the	DET
dti-1378	313	12	protein	protein	NOUN
dti-1378	313	13	sequence.45	sequence.45	NOUN
dti-1378	313	14	however	however	ADV
dti-1378	313	15	,	,	PUNCT
dti-1378	313	16	smp_059340.1	smp_059340.1	PROPN
dti-1378	313	17	is	be	AUX
dti-1378	313	18	shown	show	VERB
dti-1378	313	19	to	to	PART
dti-1378	313	20	have	have	VERB
dti-1378	313	21	high	high	ADJ
dti-1378	313	22	aliphatic	aliphatic	ADJ
dti-1378	313	23	index	index	NOUN
dti-1378	313	24	and	and	CCONJ
dti-1378	313	25	half	half	ADJ
dti-1378	313	26	-	-	PUNCT
dti-1378	313	27	life	life	NOUN
dti-1378	313	28	,	,	PUNCT
dti-1378	313	29	and	and	CCONJ
dti-1378	313	30	enough	enough	ADJ
dti-1378	313	31	hydrogen	hydrogen	NOUN
dti-1378	313	32	atoms	atom	NOUN
dti-1378	313	33	(	(	PUNCT
dti-1378	313	34	3093	3093	NUM
dti-1378	313	35	)	)	PUNCT
dti-1378	313	36	to	to	PART
dti-1378	313	37	form	form	VERB
dti-1378	313	38	hydrogen	hydrogen	NOUN
dti-1378	313	39	bonds	bond	NOUN
dti-1378	313	40	.	.	PUNCT
dti-1378	314	1	such	such	ADJ
dti-1378	314	2	hydrogen	hydrogen	NOUN
dti-1378	314	3	bonds	bond	NOUN
dti-1378	314	4	are	be	AUX
dti-1378	314	5	known	know	VERB
dti-1378	314	6	to	to	PART
dti-1378	314	7	impact	impact	VERB
dti-1378	314	8	protein	protein	NOUN
dti-1378	314	9	stability	stability	NOUN
dti-1378	314	10	significantly	significantly	ADV
dti-1378	314	11	,	,	PUNCT
dti-1378	314	12	making	make	VERB
dti-1378	314	13	them	they	PRON
dti-1378	314	14	resistant	resistant	ADJ
dti-1378	314	15	to	to	ADP
dti-1378	314	16	degradation.46	degradation.46	PROPN
dti-1378	314	17	therefore	therefore	ADV
dti-1378	314	18	,	,	PUNCT
dti-1378	314	19	it	it	PRON
dti-1378	314	20	appears	appear	VERB
dti-1378	314	21	that	that	SCONJ
dti-1378	314	22	the	the	DET
dti-1378	314	23	formation	formation	NOUN
dti-1378	314	24	of	of	ADP
dti-1378	314	25	hydrogen	hydrogen	NOUN
dti-1378	314	26	bonds	bond	NOUN
dti-1378	314	27	in	in	ADP
dti-1378	314	28	smp_059340.1	smp_059340.1	PROPN
dti-1378	314	29	may	may	AUX
dti-1378	314	30	override	override	VERB
dti-1378	314	31	the	the	DET
dti-1378	314	32	impact	impact	NOUN
dti-1378	314	33	of	of	ADP
dti-1378	314	34	dipeptides	dipeptide	NOUN
dti-1378	314	35	.	.	PUNCT
dti-1378	315	1	the	the	DET
dti-1378	315	2	calculated	calculate	VERB
dti-1378	315	3	value	value	NOUN
dti-1378	315	4	is	be	AUX
dti-1378	315	5	a	a	DET
dti-1378	315	6	measure	measure	NOUN
dti-1378	315	7	of	of	ADP
dti-1378	315	8	protein	protein	NOUN
dti-1378	315	9	stability	stability	NOUN
dti-1378	315	10	in	in	ADP
dti-1378	315	11	a	a	DET
dti-1378	315	12	test	test	NOUN
dti-1378	315	13	tube.45	tube.45	NOUN
dti-1378	315	14	a	a	DET
dti-1378	315	15	protein	protein	NOUN
dti-1378	315	16	of	of	ADP
dti-1378	315	17	instability	instability	NOUN
dti-1378	315	18	index	index	NOUN
dti-1378	315	19	,	,	PUNCT
dti-1378	315	20	40	40	NUM
dti-1378	315	21	is	be	AUX
dti-1378	315	22	considered	consider	VERB
dti-1378	315	23	as	as	ADP
dti-1378	315	24	stable	stable	ADJ
dti-1378	315	25	,	,	PUNCT
dti-1378	315	26	while	while	SCONJ
dti-1378	315	27	those	those	PRON
dti-1378	315	28	with	with	ADP
dti-1378	315	29	values	value	NOUN
dti-1378	315	30	.	.	PUNCT
dti-1378	316	1	40	40	NUM
dti-1378	316	2	are	be	AUX
dti-1378	316	3	unstable.45	unstable.45	ADJ
dti-1378	316	4	the	the	DET
dti-1378	316	5	aliphatic	aliphatic	ADJ
dti-1378	316	6	index	index	NOUN
dti-1378	316	7	(	(	PUNCT
dti-1378	316	8	ai	ai	NOUN
dti-1378	316	9	)	)	PUNCT
dti-1378	316	10	of	of	ADP
dti-1378	316	11	a	a	DET
dti-1378	316	12	protein	protein	NOUN
dti-1378	316	13	is	be	AUX
dti-1378	316	14	the	the	DET
dti-1378	316	15	relative	relative	ADJ
dti-1378	316	16	volume	volume	NOUN
dti-1378	316	17	occupied	occupy	VERB
dti-1378	316	18	by	by	ADP
dti-1378	316	19	the	the	DET
dti-1378	316	20	aliphatic	aliphatic	ADJ
dti-1378	316	21	side	side	NOUN
dti-1378	316	22	chains	chain	NOUN
dti-1378	316	23	(	(	PUNCT
dti-1378	316	24	ala	ala	INTJ
dti-1378	316	25	,	,	PUNCT
dti-1378	316	26	val	val	PROPN
dti-1378	316	27	,	,	PUNCT
dti-1378	316	28	ile	ile	PROPN
dti-1378	316	29	,	,	PUNCT
dti-1378	316	30	and	and	CCONJ
dti-1378	316	31	leu	leu	PROPN
dti-1378	316	32	)	)	PUNCT
dti-1378	316	33	and	and	CCONJ
dti-1378	316	34	is	be	AUX
dti-1378	316	35	considered	consider	VERB
dti-1378	316	36	a	a	DET
dti-1378	316	37	contributor	contributor	NOUN
dti-1378	316	38	to	to	ADP
dti-1378	316	39	the	the	DET
dti-1378	316	40	increased	increase	VERB
dti-1378	316	41	thermal	thermal	ADJ
dti-1378	316	42	stability	stability	NOUN
dti-1378	316	43	of	of	ADP
dti-1378	316	44	globular	globular	ADJ
dti-1378	316	45	proteins	protein	NOUN
dti-1378	316	46	.	.	PUNCT
dti-1378	317	1	the	the	DET
dti-1378	317	2	aliphatic	aliphatic	ADJ
dti-1378	317	3	index	index	NOUN
dti-1378	317	4	computed	compute	VERB
dti-1378	317	5	for	for	ADP
dti-1378	317	6	smp_059340.1	smp_059340.1	PROPN
dti-1378	317	7	was	be	AUX
dti-1378	317	8	82.17	82.17	NUM
dti-1378	317	9	,	,	PUNCT
dti-1378	317	10	using	use	VERB
dti-1378	317	11	a	a	DET
dti-1378	317	12	formulated	formulated	ADJ
dti-1378	317	13	rule.47	rule.47	NOUN
dti-1378	317	14	this	this	DET
dti-1378	317	15	high	high	ADJ
dti-1378	317	16	aliphatic	aliphatic	ADJ
dti-1378	317	17	index	index	NOUN
dti-1378	317	18	indicates	indicate	VERB
dti-1378	317	19	that	that	SCONJ
dti-1378	317	20	smp_059340.1	smp_059340.1	PROPN
dti-1378	317	21	can	can	AUX
dti-1378	317	22	be	be	AUX
dti-1378	317	23	stable	stable	ADJ
dti-1378	317	24	within	within	ADP
dti-1378	317	25	a	a	DET
dti-1378	317	26	wide	wide	ADJ
dti-1378	317	27	temperature	temperature	NOUN
dti-1378	317	28	range	range	NOUN
dti-1378	317	29	.	.	PUNCT
dti-1378	318	1	proteins	protein	NOUN
dti-1378	318	2	with	with	ADP
dti-1378	318	3	low	low	ADJ
dti-1378	318	4	thermal	thermal	ADJ
dti-1378	318	5	stability	stability	NOUN
dti-1378	318	6	turn	turn	VERB
dti-1378	318	7	out	out	ADP
dti-1378	318	8	to	to	PART
dti-1378	318	9	be	be	AUX
dti-1378	318	10	more	more	ADV
dti-1378	318	11	structurally	structurally	ADV
dti-1378	318	12	flexible	flexible	ADJ
dti-1378	318	13	.	.	PUNCT
dti-1378	319	1	the	the	DET
dti-1378	319	2	grand	grand	ADJ
dti-1378	319	3	average	average	NOUN
dti-1378	319	4	of	of	ADP
dti-1378	319	5	hydropathy	hydropathy	ADJ
dti-1378	319	6	(	(	PUNCT
dti-1378	319	7	gravy	gravy	NOUN
dti-1378	319	8	)	)	PUNCT
dti-1378	319	9	is	be	AUX
dti-1378	319	10	the	the	DET
dti-1378	319	11	computed	computed	ADJ
dti-1378	319	12	sum	sum	NOUN
dti-1378	319	13	of	of	ADP
dti-1378	319	14	hydropathy	hydropathy	ADJ
dti-1378	319	15	values	value	NOUN
dti-1378	319	16	of	of	ADP
dti-1378	319	17	all	all	DET
dti-1378	319	18	the	the	DET
dti-1378	319	19	amino	amino	NOUN
dti-1378	319	20	acids	acid	NOUN
dti-1378	319	21	,	,	PUNCT
dti-1378	319	22	divided	divide	VERB
dti-1378	319	23	by	by	ADP
dti-1378	319	24	the	the	DET
dti-1378	319	25	number	number	NOUN
dti-1378	319	26	of	of	ADP
dti-1378	319	27	residues	residue	NOUN
dti-1378	319	28	in	in	ADP
dti-1378	319	29	the	the	DET
dti-1378	319	30	sequence.48	sequence.48	NOUN
dti-1378	319	31	the	the	DET
dti-1378	319	32	very	very	ADV
dti-1378	319	33	low	low	ADJ
dti-1378	319	34	gravy	gravy	NOUN
dti-1378	319	35	index	index	NOUN
dti-1378	319	36	(	(	PUNCT
dti-1378	319	37	−0.458	−0.458	NOUN
dti-1378	319	38	)	)	PUNCT
dti-1378	319	39	of	of	ADP
dti-1378	319	40	smp_059340.1	smp_059340.1	PROPN
dti-1378	319	41	indicates	indicate	VERB
dti-1378	319	42	that	that	SCONJ
dti-1378	319	43	there	there	PRON
dti-1378	319	44	is	be	VERB
dti-1378	319	45	good	good	ADJ
dti-1378	319	46	interaction	interaction	NOUN
dti-1378	319	47	between	between	ADP
dti-1378	319	48	this	this	DET
dti-1378	319	49	protein	protein	NOUN
dti-1378	319	50	and	and	CCONJ
dti-1378	319	51	water	water	NOUN
dti-1378	319	52	.	.	PUNCT
dti-1378	320	1	the	the	DET
dti-1378	320	2	hopp	hopp	PROPN
dti-1378	320	3	-	-	PUNCT
dti-1378	320	4	woods	woods	PROPN
dti-1378	320	5	scale	scale	NOUN
dti-1378	320	6	identified	identify	VERB
dti-1378	320	7	three	three	NUM
dti-1378	320	8	regions	region	NOUN
dti-1378	320	9	on	on	ADP
dti-1378	320	10	this	this	DET
dti-1378	320	11	polypeptide	polypeptide	NOUN
dti-1378	320	12	predicted	predict	VERB
dti-1378	320	13	to	to	PART
dti-1378	320	14	be	be	AUX
dti-1378	320	15	highly	highly	ADV
dti-1378	320	16	hydrophilic	hydrophilic	ADJ
dti-1378	320	17	.	.	PUNCT
dti-1378	321	1	hydrophilic	hydrophilic	ADJ
dti-1378	321	2	regions	region	NOUN
dti-1378	321	3	are	be	AUX
dti-1378	321	4	exposed	expose	VERB
dti-1378	321	5	on	on	ADP
dti-1378	321	6	the	the	DET
dti-1378	321	7	surface	surface	NOUN
dti-1378	321	8	and	and	CCONJ
dti-1378	321	9	may	may	AUX
dti-1378	321	10	possibly	possibly	ADV
dti-1378	321	11	represent	represent	VERB
dti-1378	321	12	antigenic	antigenic	ADJ
dti-1378	321	13	sites,49	sites,49	NOUN
dti-1378	321	14	indicating	indicate	VERB
dti-1378	321	15	that	that	SCONJ
dti-1378	321	16	this	this	DET
dti-1378	321	17	protein	protein	NOUN
dti-1378	321	18	can	can	AUX
dti-1378	321	19	serve	serve	VERB
dti-1378	321	20	as	as	ADP
dti-1378	321	21	a	a	DET
dti-1378	321	22	possible	possible	ADJ
dti-1378	321	23	drug	drug	NOUN
dti-1378	321	24	target	target	NOUN
dti-1378	321	25	for	for	ADP
dti-1378	321	26	schistosomiasis	schistosomiasis	NOUN
dti-1378	321	27	.	.	PUNCT
dti-1378	322	1	interactions	interaction	NOUN
dti-1378	322	2	of	of	ADP
dti-1378	322	3	domain	domain	NOUN
dti-1378	322	4	-	-	PUNCT
dti-1378	322	5	specific	specific	ADJ
dti-1378	322	6	amino	amino	NOUN
dti-1378	322	7	acids	acid	NOUN
dti-1378	322	8	at	at	ADP
dti-1378	322	9	the	the	DET
dti-1378	322	10	smp_059340.1	smp_059340.1	PROPN
dti-1378	322	11	protein	protein	NOUN
dti-1378	322	12	active	active	ADJ
dti-1378	322	13	sites	site	NOUN
dti-1378	322	14	the	the	DET
dti-1378	322	15	presence	presence	NOUN
dti-1378	322	16	of	of	ADP
dti-1378	322	17	conserved	conserved	ADJ
dti-1378	322	18	domain	domain	NOUN
dti-1378	322	19	active	active	ADJ
dti-1378	322	20	sites	site	NOUN
dti-1378	322	21	within	within	ADP
dti-1378	322	22	the	the	DET
dti-1378	322	23	guanine	guanine	NOUN
dti-1378	322	24	nucleotide	nucleotide	NOUN
dti-1378	322	25	-	-	PUNCT
dti-1378	322	26	binding	bind	VERB
dti-1378	322	27	proteins	protein	NOUN
dti-1378	322	28	(	(	PUNCT
dti-1378	322	29	g	g	NOUN
dti-1378	322	30	proteins	protein	NOUN
dti-1378	322	31	)	)	PUNCT
dti-1378	322	32	is	be	AUX
dti-1378	322	33	responsible	responsible	ADJ
dti-1378	322	34	for	for	ADP
dti-1378	322	35	many	many	ADJ
dti-1378	322	36	important	important	ADJ
dti-1378	322	37	biological	biological	ADJ
dti-1378	322	38	functions	function	NOUN
dti-1378	322	39	within	within	ADP
dti-1378	322	40	the	the	DET
dti-1378	322	41	cellular	cellular	ADJ
dti-1378	322	42	process	process	NOUN
dti-1378	322	43	of	of	ADP
dti-1378	322	44	an	an	DET
dti-1378	322	45	organism.36,50	organism.36,50	NOUN
dti-1378	322	46	these	these	DET
dti-1378	322	47	functions	function	NOUN
dti-1378	322	48	range	range	VERB
dti-1378	322	49	from	from	ADP
dti-1378	322	50	signal	signal	ADJ
dti-1378	322	51	transduction	transduction	NOUN
dti-1378	322	52	,	,	PUNCT
dti-1378	322	53	protein	protein	NOUN
dti-1378	322	54	synthesis	synthesis	NOUN
dti-1378	322	55	,	,	PUNCT
dti-1378	322	56	cell	cell	NOUN
dti-1378	322	57	proliferation	proliferation	NOUN
dti-1378	322	58	,	,	PUNCT
dti-1378	322	59	protein	protein	NOUN
dti-1378	322	60	targeting	targeting	NOUN
dti-1378	322	61	,	,	PUNCT
dti-1378	322	62	membrane	membrane	NOUN
dti-1378	322	63	trafficking	trafficking	NOUN
dti-1378	322	64	and	and	CCONJ
dti-1378	322	65	secretion	secretion	NOUN
dti-1378	322	66	,	,	PUNCT
dti-1378	322	67	including	include	VERB
dti-1378	322	68	cell	cell	NOUN
dti-1378	322	69	skeletal	skeletal	ADJ
dti-1378	322	70	organization	organization	NOUN
dti-1378	322	71	and	and	CCONJ
dti-1378	322	72	movement.51–53	movement.51–53	DET
dti-1378	322	73	the	the	DET
dti-1378	322	74	sharing	sharing	NOUN
dti-1378	322	75	of	of	ADP
dti-1378	322	76	functional	functional	ADJ
dti-1378	322	77	unit	unit	NOUN
dti-1378	322	78	residues	residue	NOUN
dti-1378	322	79	among	among	ADP
dti-1378	322	80	domains	domain	NOUN
dti-1378	322	81	suggests	suggest	VERB
dti-1378	322	82	that	that	SCONJ
dti-1378	322	83	the	the	DET
dti-1378	322	84	smp_059340.1	smp_059340.1	PROPN
dti-1378	322	85	functions	function	NOUN
dti-1378	322	86	as	as	ADP
dti-1378	322	87	a	a	DET
dti-1378	322	88	highly	highly	ADV
dti-1378	322	89	interconnected	interconnected	ADJ
dti-1378	322	90	network	network	NOUN
dti-1378	322	91	of	of	ADP
dti-1378	322	92	functional	functional	ADJ
dti-1378	322	93	domains	domain	NOUN
dti-1378	322	94	,	,	PUNCT
dti-1378	322	95	as	as	SCONJ
dti-1378	322	96	will	will	AUX
dti-1378	322	97	be	be	AUX
dti-1378	322	98	explained	explain	VERB
dti-1378	322	99	below	below	ADV
dti-1378	322	100	.	.	PUNCT
dti-1378	323	1	gtp	gtp	PROPN
dti-1378	323	2	/	/	SYM
dti-1378	323	3	mg2	mg2	PROPN
dti-1378	323	4	+	+	NOUN
dti-1378	323	5	ion	ion	NOUN
dti-1378	323	6	binding	bind	VERB
dti-1378	323	7	site	site	NOUN
dti-1378	323	8	interaction	interaction	NOUN
dti-1378	323	9	the	the	DET
dti-1378	323	10	distribution	distribution	NOUN
dti-1378	323	11	of	of	ADP
dti-1378	323	12	the	the	DET
dti-1378	323	13	gtp	gtp	PROPN
dti-1378	323	14	/	/	SYM
dti-1378	323	15	mg2	mg2	PROPN
dti-1378	323	16	+	+	NOUN
dti-1378	323	17	ion	ion	NOUN
dti-1378	323	18	complex	complex	ADJ
dti-1378	323	19	binding	bind	VERB
dti-1378	323	20	site	site	NOUN
dti-1378	323	21	residues	residue	NOUN
dti-1378	323	22	and	and	CCONJ
dti-1378	323	23	their	their	PRON
dti-1378	323	24	orientation	orientation	NOUN
dti-1378	323	25	to	to	ADP
dti-1378	323	26	the	the	DET
dti-1378	323	27	active	active	ADJ
dti-1378	323	28	fold	fold	NOUN
dti-1378	323	29	may	may	AUX
dti-1378	323	30	be	be	AUX
dti-1378	323	31	seen	see	VERB
dti-1378	323	32	as	as	ADP
dti-1378	323	33	a	a	DET
dti-1378	323	34	native	native	ADJ
dti-1378	323	35	adaptation	adaptation	NOUN
dti-1378	323	36	for	for	ADP
dti-1378	323	37	efficient	efficient	ADJ
dti-1378	323	38	binding	binding	NOUN
dti-1378	323	39	of	of	ADP
dti-1378	323	40	the	the	DET
dti-1378	323	41	gtp	gtp	NOUN
dti-1378	323	42	molecule	molecule	NOUN
dti-1378	323	43	.	.	PUNCT
dti-1378	324	1	the	the	DET
dti-1378	324	2	mg2	mg2	PROPN
dti-1378	324	3	+	+	NOUN
dti-1378	324	4	ion	ion	NOUN
dti-1378	324	5	interacts	interact	VERB
dti-1378	324	6	with	with	ADP
dti-1378	324	7	alpha	alpha	ADJ
dti-1378	324	8	subunits	subunit	NOUN
dti-1378	324	9	of	of	ADP
dti-1378	324	10	the	the	DET
dti-1378	324	11	g	g	PROPN
dti-1378	324	12	proteins	protein	NOUN
dti-1378	324	13	in	in	ADP
dti-1378	324	14	the	the	DET
dti-1378	324	15	presence	presence	NOUN
dti-1378	324	16	of	of	ADP
dti-1378	324	17	gtp	gtp	NOUN
dti-1378	324	18	to	to	PART
dti-1378	324	19	form	form	VERB
dti-1378	324	20	a	a	DET
dti-1378	324	21	complex	complex	NOUN
dti-1378	324	22	,	,	PUNCT
dti-1378	324	23	from	from	ADP
dti-1378	324	24	which	which	PRON
dti-1378	324	25	nucleotides	nucleotide	NOUN
dti-1378	324	26	dissociate	dissociate	VERB
dti-1378	324	27	slowly	slowly	ADV
dti-1378	324	28	at	at	ADP
dti-1378	324	29	multiple	multiple	ADJ
dti-1378	324	30	sites	site	NOUN
dti-1378	324	31	.	.	PUNCT
dti-1378	325	1	higher	high	ADJ
dti-1378	325	2	concentrations	concentration	NOUN
dti-1378	325	3	of	of	ADP
dti-1378	325	4	the	the	DET
dti-1378	325	5	mg2	mg2	PROPN
dti-1378	325	6	+	+	NOUN
dti-1378	325	7	ion	ion	NOUN
dti-1378	325	8	have	have	AUX
dti-1378	325	9	been	be	AUX
dti-1378	325	10	documented	document	VERB
dti-1378	325	11	to	to	PART
dti-1378	325	12	promote	promote	VERB
dti-1378	325	13	the	the	DET
dti-1378	325	14	dissociation	dissociation	NOUN
dti-1378	325	15	of	of	ADP
dti-1378	325	16	gdp.54	gdp.54	PROPN
dti-1378	325	17	the	the	DET
dti-1378	325	18	dissociation	dissociation	NOUN
dti-1378	325	19	of	of	ADP
dti-1378	325	20	nucleotides	nucleotide	NOUN
dti-1378	325	21	at	at	ADP
dti-1378	325	22	multiple	multiple	ADJ
dti-1378	325	23	sites	site	NOUN
dti-1378	325	24	could	could	AUX
dti-1378	325	25	be	be	AUX
dti-1378	325	26	accounted	account	VERB
dti-1378	325	27	by	by	ADP
dti-1378	325	28	the	the	DET
dti-1378	325	29	stretch	stretch	NOUN
dti-1378	325	30	of	of	ADP
dti-1378	325	31	active	active	ADJ
dti-1378	325	32	fold	fold	NOUN
dti-1378	325	33	observed	observe	VERB
dti-1378	325	34	in	in	ADP
dti-1378	325	35	figure	figure	NOUN
dti-1378	325	36	8a	8a	NUM
dti-1378	325	37	.	.	PUNCT
dti-1378	326	1	the	the	DET
dti-1378	326	2	gtp	gtp	PROPN
dti-1378	326	3	is	be	AUX
dti-1378	326	4	bounded	bound	VERB
dti-1378	326	5	as	as	ADP
dti-1378	326	6	a	a	DET
dti-1378	326	7	complex	complex	NOUN
dti-1378	326	8	with	with	ADP
dti-1378	326	9	the	the	DET
dti-1378	326	10	mg2	mg2	PROPN
dti-1378	326	11	+	+	NOUN
dti-1378	326	12	ion	ion	NOUN
dti-1378	326	13	through	through	ADP
dti-1378	326	14	the	the	DET
dti-1378	326	15	coordination	coordination	NOUN
dti-1378	326	16	of	of	ADP
dti-1378	326	17	one	one	NUM
dti-1378	326	18	oxygen	oxygen	NOUN
dti-1378	326	19	atom	atom	NOUN
dti-1378	326	20	from	from	ADP
dti-1378	326	21	the	the	DET
dti-1378	326	22	γ	γ	NOUN
dti-1378	326	23	-	-	NOUN
dti-1378	326	24	phosphate	phosphate	NOUN
dti-1378	326	25	,	,	PUNCT
dti-1378	326	26	as	as	SCONJ
dti-1378	326	27	gαs	gαs	NOUN
dti-1378	326	28	proteins	protein	NOUN
dti-1378	326	29	are	be	AUX
dti-1378	326	30	known	know	VERB
dti-1378	326	31	to	to	PART
dti-1378	326	32	be	be	AUX
dti-1378	326	33	unstable	unstable	ADJ
dti-1378	326	34	in	in	ADP
dti-1378	326	35	the	the	DET
dti-1378	326	36	absence	absence	NOUN
dti-1378	326	37	of	of	ADP
dti-1378	326	38	a	a	DET
dti-1378	326	39	bounded	bound	VERB
dti-1378	326	40	nucleotide.55	nucleotide.55	NOUN
dti-1378	326	41	the	the	DET
dti-1378	326	42	binding	bind	VERB
dti-1378	326	43	sites	site	NOUN
dti-1378	326	44	for	for	ADP
dti-1378	326	45	both	both	PRON
dti-1378	326	46	mg2	mg2	PROPN
dti-1378	326	47	+	+	NOUN
dti-1378	326	48	ion	ion	NOUN
dti-1378	326	49	and	and	CCONJ
dti-1378	326	50	gtp	gtp	NOUN
dti-1378	326	51	are	be	AUX
dti-1378	326	52	strongly	strongly	ADV
dti-1378	326	53	linked	link	VERB
dti-1378	326	54	together.54	together.54	PROPN
dti-1378	326	55	we	we	PRON
dti-1378	326	56	found	find	VERB
dti-1378	326	57	that	that	SCONJ
dti-1378	326	58	the	the	DET
dti-1378	326	59	gtp	gtp	PROPN
dti-1378	326	60	/	/	SYM
dti-1378	326	61	mg2	mg2	PROPN
dti-1378	326	62	+	+	NOUN
dti-1378	326	63	ion	ion	NOUN
dti-1378	326	64	binding	bind	VERB
dti-1378	326	65	site	site	NOUN
dti-1378	326	66	shares	share	VERB
dti-1378	326	67	four	four	NUM
dti-1378	326	68	common	common	ADJ
dti-1378	326	69	residues	residue	NOUN
dti-1378	326	70	with	with	ADP
dti-1378	326	71	the	the	DET
dti-1378	326	72	g1	g1	PROPN
dti-1378	326	73	box	box	NOUN
dti-1378	326	74	motif	motif	NOUN
dti-1378	326	75	at	at	ADP
dti-1378	326	76	residues	residue	NOUN
dti-1378	326	77	gly46	gly46	PROPN
dti-1378	326	78	,	,	PUNCT
dti-1378	326	79	gly51	gly51	PROPN
dti-1378	326	80	,	,	PUNCT
dti-1378	326	81	lys52	lys52	NOUN
dti-1378	326	82	and	and	CCONJ
dti-1378	326	83	ser53	ser53	PROPN
dti-1378	326	84	(	(	PUNCT
dti-1378	326	85	table	table	NOUN
dti-1378	326	86	5	5	NUM
dti-1378	326	87	)	)	PUNCT
dti-1378	326	88	.	.	PUNCT
dti-1378	327	1	the	the	DET
dti-1378	327	2	g1	g1	PROPN
dti-1378	327	3	box	box	NOUN
dti-1378	327	4	motif	motif	NOUN
dti-1378	327	5	is	be	AUX
dti-1378	327	6	one	one	NUM
dti-1378	327	7	of	of	ADP
dti-1378	327	8	the	the	DET
dti-1378	327	9	five	five	NUM
dti-1378	327	10	polypeptide	polypeptide	ADJ
dti-1378	327	11	loops	loop	NOUN
dti-1378	327	12	that	that	PRON
dti-1378	327	13	form	form	VERB
dti-1378	327	14	the	the	DET
dti-1378	327	15	guanine	guanine	NOUN
dti-1378	327	16	nucleotide	nucleotide	NOUN
dti-1378	327	17	-	-	PUNCT
dti-1378	327	18	binding	bind	VERB
dti-1378	327	19	site	site	NOUN
dti-1378	327	20	with	with	ADP
dti-1378	327	21	well	well	ADV
dti-1378	327	22	-	-	PUNCT
dti-1378	327	23	conserved	conserve	VERB
dti-1378	327	24	elements	element	NOUN
dti-1378	327	25	in	in	ADP
dti-1378	327	26	the	the	DET
dti-1378	327	27	domain	domain	NOUN
dti-1378	327	28	.	.	PUNCT
dti-1378	328	1	it	it	PRON
dti-1378	328	2	is	be	AUX
dti-1378	328	3	also	also	ADV
dti-1378	328	4	called	call	VERB
dti-1378	328	5	the	the	DET
dti-1378	328	6	walker	walker	NOUN
dti-1378	328	7	a	a	DET
dti-1378	328	8	motif	motif	NOUN
dti-1378	328	9	,	,	PUNCT
dti-1378	328	10	and	and	CCONJ
dti-1378	328	11	has	have	AUX
dti-1378	328	12	been	be	AUX
dti-1378	328	13	used	use	VERB
dti-1378	328	14	to	to	PART
dti-1378	328	15	define	define	VERB
dti-1378	328	16	the	the	DET
dti-1378	328	17	g	g	PROPN
dti-1378	328	18	protein	protein	NOUN
dti-1378	328	19	http://www.la-press.com	http://www.la-press.com	X
dti-1378	328	20	mbah	mbah	PROPN
dti-1378	328	21	et	et	PROPN
dti-1378	328	22	al	al	PROPN
dti-1378	328	23	54	54	NUM
dti-1378	328	24	drug	drug	NOUN
dti-1378	328	25	target	target	NOUN
dti-1378	328	26	insights	insight	NOUN
dti-1378	328	27	2012:6	2012:6	NUM
dti-1378	328	28	superfamily	superfamily	ADV
dti-1378	328	29	and	and	CCONJ
dti-1378	328	30	its	its	PRON
dti-1378	328	31	ability	ability	NOUN
dti-1378	328	32	to	to	PART
dti-1378	328	33	bind	bind	VERB
dti-1378	328	34	guanine	guanine	NOUN
dti-1378	328	35	nucleotide	nucleotide	NOUN
dti-1378	328	36	such	such	ADJ
dti-1378	328	37	as	as	ADP
dti-1378	328	38	gtp.33	gtp.33	PROPN
dti-1378	328	39	the	the	DET
dti-1378	328	40	shared	share	VERB
dti-1378	328	41	residues	residue	NOUN
dti-1378	328	42	between	between	ADP
dti-1378	328	43	the	the	DET
dti-1378	328	44	gtp/	gtp/	NOUN
dti-1378	328	45	mg2	mg2	PROPN
dti-1378	328	46	+	+	NOUN
dti-1378	328	47	ion	ion	NOUN
dti-1378	328	48	binding	bind	VERB
dti-1378	328	49	site	site	NOUN
dti-1378	328	50	and	and	CCONJ
dti-1378	328	51	the	the	DET
dti-1378	328	52	g1	g1	PROPN
dti-1378	328	53	box	box	NOUN
dti-1378	328	54	motif	motif	NOUN
dti-1378	328	55	could	could	AUX
dti-1378	328	56	account	account	VERB
dti-1378	328	57	for	for	ADP
dti-1378	328	58	the	the	DET
dti-1378	328	59	binding	binding	NOUN
dti-1378	328	60	of	of	ADP
dti-1378	328	61	gtp	gtp	NOUN
dti-1378	328	62	at	at	ADP
dti-1378	328	63	the	the	DET
dti-1378	328	64	gtp	gtp	PROPN
dti-1378	328	65	/	/	SYM
dti-1378	328	66	mg2	mg2	PROPN
dti-1378	328	67	+	+	NOUN
dti-1378	328	68	ion	ion	NOUN
dti-1378	328	69	binding	bind	VERB
dti-1378	328	70	site	site	NOUN
dti-1378	328	71	domain	domain	NOUN
dti-1378	328	72	.	.	PUNCT
dti-1378	329	1	we	we	PRON
dti-1378	329	2	also	also	ADV
dti-1378	329	3	found	find	VERB
dti-1378	329	4	that	that	SCONJ
dti-1378	329	5	the	the	DET
dti-1378	329	6	gtp	gtp	PROPN
dti-1378	329	7	/	/	SYM
dti-1378	329	8	mg2	mg2	PROPN
dti-1378	329	9	+	+	NOUN
dti-1378	329	10	ion	ion	NOUN
dti-1378	329	11	binding	bind	VERB
dti-1378	329	12	site	site	NOUN
dti-1378	329	13	converged	converge	VERB
dti-1378	329	14	at	at	ADP
dti-1378	329	15	two	two	NUM
dti-1378	329	16	plastic	plastic	ADJ
dti-1378	329	17	regions	region	NOUN
dti-1378	329	18	of	of	ADP
dti-1378	329	19	switch	switch	NOUN
dti-1378	329	20	i	i	PRON
dti-1378	329	21	(	(	PUNCT
dti-1378	329	22	g2	g2	PROPN
dti-1378	329	23	box	box	PROPN
dti-1378	329	24	motif	motif	NOUN
dti-1378	329	25	-	-	PUNCT
dti-1378	329	26	thr188	thr188	PROPN
dti-1378	329	27	)	)	PUNCT
dti-1378	329	28	and	and	CCONJ
dti-1378	329	29	switch	switch	VERB
dti-1378	329	30	ii	ii	PROPN
dti-1378	329	31	(	(	PUNCT
dti-1378	329	32	gly210	gly210	NOUN
dti-1378	329	33	;	;	PUNCT
dti-1378	329	34	table	table	NOUN
dti-1378	329	35	5	5	NUM
dti-1378	329	36	)	)	PUNCT
dti-1378	329	37	.	.	PUNCT
dti-1378	330	1	the	the	DET
dti-1378	330	2	coupling	coupling	NOUN
dti-1378	330	3	between	between	ADP
dti-1378	330	4	the	the	DET
dti-1378	330	5	gtp	gtp	PROPN
dti-1378	330	6	-	-	PUNCT
dti-1378	330	7	γ	γ	NOUN
dti-1378	330	8	-	-	ADJ
dti-1378	330	9	phosphate	phosphate	ADJ
dti-1378	330	10	site	site	NOUN
dti-1378	330	11	and	and	CCONJ
dti-1378	330	12	the	the	DET
dti-1378	330	13	mg2	mg2	PROPN
dti-1378	330	14	+	+	PROPN
dti-1378	330	15	ion	ion	NOUN
dti-1378	330	16	may	may	AUX
dti-1378	330	17	be	be	AUX
dti-1378	330	18	accounted	account	VERB
dti-1378	330	19	for	for	ADP
dti-1378	330	20	by	by	ADP
dti-1378	330	21	the	the	DET
dti-1378	330	22	rigidity	rigidity	NOUN
dti-1378	330	23	of	of	ADP
dti-1378	330	24	the	the	DET
dti-1378	330	25	switch	switch	NOUN
dti-1378	330	26	i	i	PRON
dti-1378	330	27	/	/	SYM
dti-1378	330	28	switch	switch	PROPN
dti-1378	330	29	ii	ii	PROPN
dti-1378	330	30	interface.56	interface.56	VERB
dti-1378	330	31	the	the	DET
dti-1378	330	32	key	key	ADJ
dti-1378	330	33	residue	residue	NOUN
dti-1378	330	34	could	could	AUX
dti-1378	330	35	be	be	AUX
dti-1378	330	36	thr188	thr188	NOUN
dti-1378	330	37	,	,	PUNCT
dti-1378	330	38	which	which	PRON
dti-1378	330	39	binds	bind	VERB
dti-1378	330	40	the	the	DET
dti-1378	330	41	magnesium	magnesium	NOUN
dti-1378	330	42	ions	ion	NOUN
dti-1378	330	43	of	of	ADP
dti-1378	330	44	the	the	DET
dti-1378	330	45	mg	mg	PROPN
dti-1378	330	46	-	-	PUNCT
dti-1378	330	47	gtp	gtp	NOUN
dti-1378	330	48	complex	complex	NOUN
dti-1378	330	49	,	,	PUNCT
dti-1378	330	50	allowing	allow	VERB
dti-1378	330	51	it	it	PRON
dti-1378	330	52	to	to	PART
dti-1378	330	53	sense	sense	VERB
dti-1378	330	54	the	the	DET
dti-1378	330	55	presence	presence	NOUN
dti-1378	330	56	of	of	ADP
dti-1378	330	57	the	the	DET
dti-1378	330	58	γphosphate	γphosphate	NOUN
dti-1378	330	59	found	find	VERB
dti-1378	330	60	in	in	ADP
dti-1378	330	61	gtp	gtp	NOUN
dti-1378	330	62	molecules	molecule	NOUN
dti-1378	330	63	.	.	PUNCT
dti-1378	331	1	the	the	DET
dti-1378	331	2	gtp	gtp	PROPN
dti-1378	331	3	/	/	SYM
dti-1378	331	4	mg2	mg2	PROPN
dti-1378	331	5	+	+	NOUN
dti-1378	331	6	ion	ion	NOUN
dti-1378	331	7	binding	bind	VERB
dti-1378	331	8	site	site	NOUN
dti-1378	331	9	also	also	ADV
dti-1378	331	10	shares	share	VERB
dti-1378	331	11	some	some	DET
dti-1378	331	12	conserved	conserved	ADJ
dti-1378	331	13	residues	residue	NOUN
dti-1378	331	14	with	with	ADP
dti-1378	331	15	the	the	DET
dti-1378	331	16	g3	g3	PROPN
dti-1378	331	17	box	box	NOUN
dti-1378	331	18	motif	motif	NOUN
dti-1378	331	19	at	at	ADP
dti-1378	331	20	asp207	asp207	PROPN
dti-1378	331	21	(	(	PUNCT
dti-1378	331	22	table	table	NOUN
dti-1378	331	23	5	5	NUM
dti-1378	331	24	)	)	PUNCT
dti-1378	331	25	.	.	PUNCT
dti-1378	332	1	the	the	DET
dti-1378	332	2	conserved	conserve	VERB
dti-1378	332	3	asp207	asp207	NOUN
dti-1378	332	4	residue	residue	NOUN
dti-1378	332	5	in	in	ADP
dti-1378	332	6	the	the	DET
dti-1378	332	7	g3	g3	PROPN
dti-1378	332	8	box	box	NOUN
dti-1378	332	9	motif	motif	NOUN
dti-1378	332	10	also	also	ADV
dti-1378	332	11	coordinates	coordinate	VERB
dti-1378	332	12	the	the	DET
dti-1378	332	13	mg2	mg2	PROPN
dti-1378	332	14	+	+	NOUN
dti-1378	332	15	ion	ion	NOUN
dti-1378	332	16	through	through	ADP
dti-1378	332	17	a	a	DET
dti-1378	332	18	water	water	NOUN
dti-1378	332	19	molecule	molecule	NOUN
dti-1378	332	20	.	.	PUNCT
dti-1378	333	1	this	this	DET
dti-1378	333	2	coordination	coordination	NOUN
dti-1378	333	3	could	could	AUX
dti-1378	333	4	also	also	ADV
dti-1378	333	5	be	be	AUX
dti-1378	333	6	crucial	crucial	ADJ
dti-1378	333	7	for	for	ADP
dti-1378	333	8	the	the	DET
dti-1378	333	9	tight	tight	ADJ
dti-1378	333	10	linkage	linkage	NOUN
dti-1378	333	11	of	of	ADP
dti-1378	333	12	both	both	CCONJ
dti-1378	333	13	the	the	DET
dti-1378	333	14	mg2	mg2	PROPN
dti-1378	333	15	+	+	NOUN
dti-1378	333	16	ion	ion	NOUN
dti-1378	333	17	and	and	CCONJ
dti-1378	333	18	the	the	DET
dti-1378	333	19	gtp	gtp	NOUN
dti-1378	333	20	binding	bind	VERB
dti-1378	333	21	sites	site	NOUN
dti-1378	333	22	.	.	PUNCT
dti-1378	334	1	in	in	ADP
dti-1378	334	2	the	the	DET
dti-1378	334	3	gtp	gtp	PROPN
dti-1378	334	4	/	/	SYM
dti-1378	334	5	mg2	mg2	PROPN
dti-1378	334	6	+	+	NOUN
dti-1378	334	7	ion	ion	NOUN
dti-1378	334	8	complex	complex	NOUN
dti-1378	334	9	,	,	PUNCT
dti-1378	334	10	the	the	DET
dti-1378	334	11	ligand	ligand	ADJ
dti-1378	334	12	bonds	bond	NOUN
dti-1378	334	13	are	be	AUX
dti-1378	334	14	contributed	contribute	VERB
dti-1378	334	15	to	to	ADP
dti-1378	334	16	by	by	ADP
dti-1378	334	17	both	both	CCONJ
dti-1378	334	18	the	the	DET
dti-1378	334	19	β	β	NOUN
dti-1378	334	20	and	and	CCONJ
dti-1378	334	21	γ	γ	X
dti-1378	334	22	phosphates	phosphate	NOUN
dti-1378	334	23	of	of	ADP
dti-1378	334	24	the	the	DET
dti-1378	334	25	gtp	gtp	NOUN
dti-1378	334	26	molecule	molecule	NOUN
dti-1378	334	27	,	,	PUNCT
dti-1378	334	28	as	as	ADV
dti-1378	334	29	well	well	ADV
dti-1378	334	30	as	as	ADP
dti-1378	334	31	by	by	ADP
dti-1378	334	32	thr188	thr188	NOUN
dti-1378	334	33	and	and	CCONJ
dti-1378	334	34	the	the	DET
dti-1378	334	35	water	water	NOUN
dti-1378	334	36	molecules	molecule	NOUN
dti-1378	334	37	.	.	PUNCT
dti-1378	335	1	the	the	DET
dti-1378	335	2	asp207	asp207	NOUN
dti-1378	335	3	in	in	ADP
dti-1378	335	4	the	the	DET
dti-1378	335	5	g3	g3	PROPN
dti-1378	335	6	box	box	PROPN
dti-1378	335	7	motif	motif	NOUN
dti-1378	335	8	binds	bind	VERB
dti-1378	335	9	to	to	ADP
dti-1378	335	10	one	one	NUM
dti-1378	335	11	of	of	ADP
dti-1378	335	12	the	the	DET
dti-1378	335	13	water	water	NOUN
dti-1378	335	14	molecules	molecule	NOUN
dti-1378	335	15	in	in	ADP
dti-1378	335	16	the	the	DET
dti-1378	335	17	process	process	NOUN
dti-1378	335	18	.	.	PUNCT
dti-1378	336	1	there	there	PRON
dti-1378	336	2	is	be	VERB
dti-1378	336	3	also	also	ADV
dti-1378	336	4	possible	possible	ADJ
dti-1378	336	5	hydrogen	hydrogen	NOUN
dti-1378	336	6	bond	bond	NOUN
dti-1378	336	7	formation	formation	NOUN
dti-1378	336	8	with	with	ADP
dti-1378	336	9	the	the	DET
dti-1378	336	10	α	α	NOUN
dti-1378	336	11	-	-	ADJ
dti-1378	336	12	phosphate	phosphate	ADJ
dti-1378	336	13	oxygen	oxygen	NOUN
dti-1378	336	14	atom	atom	NOUN
dti-1378	336	15	from	from	ADP
dti-1378	336	16	the	the	DET
dti-1378	336	17	gtp	gtp	NOUN
dti-1378	336	18	molecule	molecule	NOUN
dti-1378	336	19	.	.	PUNCT
dti-1378	337	1	the	the	DET
dti-1378	337	2	gtp	gtp	PROPN
dti-1378	337	3	/	/	SYM
dti-1378	337	4	mg2	mg2	PROPN
dti-1378	337	5	+	+	NOUN
dti-1378	337	6	ion	ion	NOUN
dti-1378	337	7	binding	bind	VERB
dti-1378	337	8	site	site	NOUN
dti-1378	337	9	also	also	ADV
dti-1378	337	10	shares	share	VERB
dti-1378	337	11	some	some	DET
dti-1378	337	12	common	common	ADJ
dti-1378	337	13	residues	residue	NOUN
dti-1378	337	14	with	with	ADP
dti-1378	337	15	the	the	DET
dti-1378	337	16	g4	g4	NOUN
dti-1378	337	17	box	box	NOUN
dti-1378	337	18	motif	motif	NOUN
dti-1378	337	19	(	(	PUNCT
dti-1378	337	20	asn276	asn276	NOUN
dti-1378	337	21	,	,	PUNCT
dti-1378	337	22	lys277	lys277	NOUN
dti-1378	337	23	and	and	CCONJ
dti-1378	337	24	asp279	asp279	NOUN
dti-1378	337	25	;	;	PUNCT
dti-1378	337	26	table	table	NOUN
dti-1378	337	27	5	5	NUM
dti-1378	337	28	)	)	PUNCT
dti-1378	337	29	.	.	PUNCT
dti-1378	338	1	the	the	DET
dti-1378	338	2	g4	g4	NOUN
dti-1378	338	3	box	box	NOUN
dti-1378	338	4	motif	motif	NOUN
dti-1378	338	5	functions	function	NOUN
dti-1378	338	6	to	to	PART
dti-1378	338	7	recognize	recognize	VERB
dti-1378	338	8	the	the	DET
dti-1378	338	9	guanine	guanine	NOUN
dti-1378	338	10	ring	ring	NOUN
dti-1378	338	11	,	,	PUNCT
dti-1378	338	12	suggesting	suggest	VERB
dti-1378	338	13	that	that	SCONJ
dti-1378	338	14	the	the	DET
dti-1378	338	15	mg	mg	PROPN
dti-1378	338	16	-	-	PUNCT
dti-1378	338	17	gtp	gtp	NOUN
dti-1378	338	18	complex	complex	ADJ
dti-1378	338	19	binding	bind	VERB
dti-1378	338	20	site	site	NOUN
dti-1378	338	21	can	can	AUX
dti-1378	338	22	be	be	AUX
dti-1378	338	23	regarded	regard	VERB
dti-1378	338	24	as	as	ADP
dti-1378	338	25	the	the	DET
dti-1378	338	26	initiating	initiate	VERB
dti-1378	338	27	point	point	NOUN
dti-1378	338	28	for	for	ADP
dti-1378	338	29	the	the	DET
dti-1378	338	30	adenylyl	adenylyl	NOUN
dti-1378	338	31	cyclase	cyclase	NOUN
dti-1378	338	32	metabolic	metabolic	NOUN
dti-1378	338	33	pathway	pathway	NOUN
dti-1378	338	34	.	.	PUNCT
dti-1378	339	1	the	the	DET
dti-1378	339	2	methylene	methylene	ADJ
dti-1378	339	3	group	group	NOUN
dti-1378	339	4	of	of	ADP
dti-1378	339	5	the	the	DET
dti-1378	339	6	common	common	ADJ
dti-1378	339	7	lys277	lys277	NOUN
dti-1378	339	8	residue	residue	NOUN
dti-1378	339	9	of	of	ADP
dti-1378	339	10	both	both	CCONJ
dti-1378	339	11	the	the	DET
dti-1378	339	12	gtp	gtp	PROPN
dti-1378	339	13	/	/	SYM
dti-1378	339	14	mg2	mg2	PROPN
dti-1378	339	15	+	+	NOUN
dti-1378	339	16	ion	ion	NOUN
dti-1378	339	17	complex	complex	ADJ
dti-1378	339	18	binding	bind	VERB
dti-1378	339	19	site	site	NOUN
dti-1378	339	20	and	and	CCONJ
dti-1378	339	21	the	the	DET
dti-1378	339	22	g4	g4	NOUN
dti-1378	339	23	motif	motif	NOUN
dti-1378	339	24	might	might	AUX
dti-1378	339	25	be	be	AUX
dti-1378	339	26	providing	provide	VERB
dti-1378	339	27	the	the	DET
dti-1378	339	28	hydrophobic	hydrophobic	NOUN
dti-1378	339	29	surface	surface	NOUN
dti-1378	339	30	that	that	PRON
dti-1378	339	31	lies	lie	VERB
dti-1378	339	32	over	over	ADP
dti-1378	339	33	the	the	DET
dti-1378	339	34	purine	purine	NOUN
dti-1378	339	35	ring57	ring57	NOUN
dti-1378	339	36	during	during	ADP
dti-1378	339	37	the	the	DET
dti-1378	339	38	binding	bind	VERB
dti-1378	339	39	process	process	NOUN
dti-1378	339	40	.	.	PUNCT
dti-1378	340	1	beta	beta	NOUN
dti-1378	340	2	-	-	PUNCT
dti-1378	340	3	gamma	gamma	NOUN
dti-1378	340	4	complex	complex	NOUN
dti-1378	340	5	and	and	CCONJ
dti-1378	340	6	goloco	goloco	ADJ
dti-1378	340	7	binding	bind	VERB
dti-1378	340	8	interaction	interaction	NOUN
dti-1378	340	9	site	site	NOUN
dti-1378	340	10	on	on	ADP
dti-1378	340	11	the	the	DET
dti-1378	340	12	protein	protein	NOUN
dti-1378	340	13	folded	fold	VERB
dti-1378	340	14	structure	structure	NOUN
dti-1378	340	15	,	,	PUNCT
dti-1378	340	16	the	the	DET
dti-1378	340	17	beta	beta	NOUN
dti-1378	340	18	-	-	PUNCT
dti-1378	340	19	gamma	gamma	NOUN
dti-1378	340	20	complex	complex	ADJ
dti-1378	340	21	site	site	NOUN
dti-1378	340	22	is	be	AUX
dti-1378	340	23	positioned	position	VERB
dti-1378	340	24	on	on	ADP
dti-1378	340	25	the	the	DET
dti-1378	340	26	surface	surface	NOUN
dti-1378	340	27	in	in	ADP
dti-1378	340	28	close	close	ADJ
dti-1378	340	29	proximity	proximity	NOUN
dti-1378	340	30	to	to	ADP
dti-1378	340	31	the	the	DET
dti-1378	340	32	location	location	NOUN
dti-1378	340	33	of	of	ADP
dti-1378	340	34	the	the	DET
dti-1378	340	35	gtp	gtp	PROPN
dti-1378	340	36	/	/	SYM
dti-1378	340	37	mg2	mg2	PROPN
dti-1378	340	38	+	+	NOUN
dti-1378	340	39	ion	ion	NOUN
dti-1378	340	40	complex	complex	ADJ
dti-1378	340	41	binding	bind	VERB
dti-1378	340	42	site	site	NOUN
dti-1378	340	43	,	,	PUNCT
dti-1378	340	44	adenylyl	adenylyl	NOUN
dti-1378	340	45	cyclase	cyclase	NOUN
dti-1378	340	46	interaction	interaction	NOUN
dti-1378	340	47	site	site	NOUN
dti-1378	340	48	and	and	CCONJ
dti-1378	340	49	goloco	goloco	ADJ
dti-1378	340	50	binding	bind	VERB
dti-1378	340	51	site	site	NOUN
dti-1378	340	52	.	.	PUNCT
dti-1378	341	1	this	this	DET
dti-1378	341	2	closeness	closeness	NOUN
dti-1378	341	3	helps	help	VERB
dti-1378	341	4	both	both	CCONJ
dti-1378	341	5	the	the	DET
dti-1378	341	6	beta	beta	NOUN
dti-1378	341	7	-	-	PUNCT
dti-1378	341	8	gamma	gamma	NOUN
dti-1378	341	9	complex	complex	NOUN
dti-1378	341	10	and	and	CCONJ
dti-1378	341	11	the	the	DET
dti-1378	341	12	goloco	goloco	NOUN
dti-1378	341	13	site	site	NOUN
dti-1378	341	14	in	in	ADP
dti-1378	341	15	influencing	influence	VERB
dti-1378	341	16	the	the	DET
dti-1378	341	17	activity	activity	NOUN
dti-1378	341	18	of	of	ADP
dti-1378	341	19	the	the	DET
dti-1378	341	20	gtp	gtp	PROPN
dti-1378	341	21	/	/	SYM
dti-1378	341	22	mg2	mg2	PROPN
dti-1378	341	23	+	+	NOUN
dti-1378	341	24	ion	ion	NOUN
dti-1378	341	25	complex	complex	ADJ
dti-1378	341	26	binding	bind	VERB
dti-1378	341	27	site	site	NOUN
dti-1378	341	28	,	,	PUNCT
dti-1378	341	29	the	the	DET
dti-1378	341	30	adenylyl	adenylyl	NOUN
dti-1378	341	31	cyclase	cyclase	NOUN
dti-1378	341	32	interaction	interaction	NOUN
dti-1378	341	33	site	site	NOUN
dti-1378	341	34	and	and	CCONJ
dti-1378	341	35	the	the	DET
dti-1378	341	36	switch	switch	NOUN
dti-1378	341	37	ii	ii	PROPN
dti-1378	341	38	region	region	NOUN
dti-1378	341	39	respectively	respectively	ADV
dti-1378	341	40	.	.	PUNCT
dti-1378	342	1	however	however	ADV
dti-1378	342	2	,	,	PUNCT
dti-1378	342	3	the	the	DET
dti-1378	342	4	betagamma	betagamma	PROPN
dti-1378	342	5	complex	complex	NOUN
dti-1378	342	6	can	can	AUX
dti-1378	342	7	stimulate	stimulate	VERB
dti-1378	342	8	and	and	CCONJ
dti-1378	342	9	inhibit	inhibit	VERB
dti-1378	342	10	adenylyl	adenylyl	NOUN
dti-1378	342	11	cyclase	cyclase	NOUN
dti-1378	342	12	activity.58	activity.58	NOUN
dti-1378	342	13	this	this	DET
dti-1378	342	14	inhibition	inhibition	NOUN
dti-1378	342	15	might	might	AUX
dti-1378	342	16	be	be	AUX
dti-1378	342	17	through	through	ADP
dti-1378	342	18	the	the	DET
dti-1378	342	19	common	common	ADJ
dti-1378	342	20	shared	share	VERB
dti-1378	342	21	residues	residue	NOUN
dti-1378	342	22	(	(	PUNCT
dti-1378	342	23	ile191	ile191	PROPN
dti-1378	342	24	,	,	PUNCT
dti-1378	342	25	gln220	gln220	NOUN
dti-1378	342	26	and	and	CCONJ
dti-1378	342	27	asn223	asn223	PROPN
dti-1378	342	28	)	)	PUNCT
dti-1378	342	29	with	with	ADP
dti-1378	342	30	the	the	DET
dti-1378	342	31	beta	beta	NOUN
dti-1378	342	32	-	-	PUNCT
dti-1378	342	33	gamma	gamma	NOUN
dti-1378	342	34	complex	complex	NOUN
dti-1378	342	35	,	,	PUNCT
dti-1378	342	36	although	although	SCONJ
dti-1378	342	37	no	no	DET
dti-1378	342	38	model	model	NOUN
dti-1378	342	39	for	for	ADP
dti-1378	342	40	this	this	DET
dti-1378	342	41	function	function	NOUN
dti-1378	342	42	had	have	AUX
dti-1378	342	43	been	be	AUX
dti-1378	342	44	established	establish	VERB
dti-1378	342	45	.	.	PUNCT
dti-1378	343	1	the	the	DET
dti-1378	343	2	beta	beta	NOUN
dti-1378	343	3	-	-	PUNCT
dti-1378	343	4	gamma	gamma	NOUN
dti-1378	343	5	complex	complex	NOUN
dti-1378	343	6	also	also	ADV
dti-1378	343	7	shares	share	VERB
dti-1378	343	8	gly210	gly210	NOUN
dti-1378	343	9	with	with	ADP
dti-1378	343	10	the	the	DET
dti-1378	343	11	g3	g3	PROPN
dti-1378	343	12	box	box	NOUN
dti-1378	343	13	motif	motif	NOUN
dti-1378	343	14	.	.	PUNCT
dti-1378	344	1	there	there	PRON
dti-1378	344	2	is	be	VERB
dti-1378	344	3	a	a	DET
dti-1378	344	4	possible	possible	ADJ
dti-1378	344	5	hydrogen	hydrogen	NOUN
dti-1378	344	6	bond	bond	NOUN
dti-1378	344	7	formation	formation	NOUN
dti-1378	344	8	between	between	ADP
dti-1378	344	9	the	the	DET
dti-1378	344	10	γ	γ	NOUN
dti-1378	344	11	-	-	NOUN
dti-1378	344	12	phosphate	phosphate	NOUN
dti-1378	344	13	of	of	ADP
dti-1378	344	14	gtp	gtp	NOUN
dti-1378	344	15	and	and	CCONJ
dti-1378	344	16	the	the	DET
dti-1378	344	17	main	main	ADJ
dti-1378	344	18	chain	chain	NOUN
dti-1378	344	19	amide	amide	NOUN
dti-1378	344	20	of	of	ADP
dti-1378	344	21	the	the	DET
dti-1378	344	22	conserved	conserve	VERB
dti-1378	344	23	gly210	gly210	NOUN
dti-1378	344	24	in	in	ADP
dti-1378	344	25	the	the	DET
dti-1378	344	26	g3	g3	PROPN
dti-1378	344	27	box	box	PROPN
dti-1378	344	28	.	.	PUNCT
dti-1378	345	1	the	the	DET
dti-1378	345	2	stimulation	stimulation	NOUN
dti-1378	345	3	or	or	CCONJ
dti-1378	345	4	inhibition	inhibition	NOUN
dti-1378	345	5	of	of	ADP
dti-1378	345	6	adenylyl	adenylyl	ADJ
dti-1378	345	7	cyclase	cyclase	NOUN
dti-1378	345	8	activity	activity	NOUN
dti-1378	345	9	may	may	AUX
dti-1378	345	10	be	be	AUX
dti-1378	345	11	linked	link	VERB
dti-1378	345	12	to	to	ADP
dti-1378	345	13	gly210	gly210	PROPN
dti-1378	345	14	residue	residue	NOUN
dti-1378	345	15	,	,	PUNCT
dti-1378	345	16	considering	consider	VERB
dti-1378	345	17	its	its	PRON
dti-1378	345	18	function	function	NOUN
dti-1378	345	19	during	during	ADP
dti-1378	345	20	the	the	DET
dti-1378	345	21	binding	binding	NOUN
dti-1378	345	22	of	of	ADP
dti-1378	345	23	the	the	DET
dti-1378	345	24	gtp	gtp	PROPN
dti-1378	345	25	/	/	SYM
dti-1378	345	26	mg2	mg2	PROPN
dti-1378	345	27	+	+	NOUN
dti-1378	345	28	ion	ion	NOUN
dti-1378	345	29	complex	complex	NOUN
dti-1378	345	30	.	.	PUNCT
dti-1378	346	1	the	the	DET
dti-1378	346	2	beta	beta	NOUN
dti-1378	346	3	-	-	PUNCT
dti-1378	346	4	gamma	gamma	NOUN
dti-1378	346	5	complex	complex	NOUN
dti-1378	346	6	also	also	ADV
dti-1378	346	7	shares	share	VERB
dti-1378	346	8	two	two	NUM
dti-1378	346	9	residues	residue	NOUN
dti-1378	346	10	(	(	PUNCT
dti-1378	346	11	ser189	ser189	NOUN
dti-1378	346	12	and	and	CCONJ
dti-1378	346	13	ile189	ile189	PROPN
dti-1378	346	14	)	)	PUNCT
dti-1378	346	15	with	with	ADP
dti-1378	346	16	switch	switch	NOUN
dti-1378	346	17	i	i	PRON
dti-1378	346	18	,	,	PUNCT
dti-1378	346	19	and	and	CCONJ
dti-1378	346	20	10	10	NUM
dti-1378	346	21	residues	residue	NOUN
dti-1378	346	22	(	(	PUNCT
dti-1378	346	23	gly210	gly210	NOUN
dti-1378	346	24	,	,	PUNCT
dti-1378	346	25	gln211	gln211	PROPN
dti-1378	346	26	,	,	PUNCT
dti-1378	346	27	arg212	arg212	PROPN
dti-1378	346	28	,	,	PUNCT
dti-1378	346	29	glu214	glu214	ADJ
dti-1378	346	30	,	,	PUNCT
dti-1378	346	31	lys217	lys217	PROPN
dti-1378	346	32	,	,	PUNCT
dti-1378	346	33	trp218	trp218	PROPN
dti-1378	346	34	,	,	PUNCT
dti-1378	346	35	gln220	gln220	PROPN
dti-1378	346	36	,	,	PUNCT
dti-1378	346	37	cys221	cys221	NOUN
dti-1378	346	38	,	,	PUNCT
dti-1378	346	39	phe222	phe222	PROPN
dti-1378	346	40	and	and	CCONJ
dti-1378	346	41	asn223	asn223	PROPN
dti-1378	346	42	)	)	PUNCT
dti-1378	346	43	with	with	ADP
dti-1378	346	44	switch	switch	NOUN
dti-1378	346	45	ii	ii	PROPN
dti-1378	346	46	(	(	PUNCT
dti-1378	346	47	table	table	NOUN
dti-1378	346	48	1	1	NUM
dti-1378	346	49	)	)	PUNCT
dti-1378	346	50	.	.	PUNCT
dti-1378	347	1	this	this	DET
dti-1378	347	2	residue	residue	NOUN
dti-1378	347	3	sharing	sharing	NOUN
dti-1378	347	4	suggests	suggest	VERB
dti-1378	347	5	that	that	SCONJ
dti-1378	347	6	the	the	DET
dti-1378	347	7	beta	beta	NOUN
dti-1378	347	8	-	-	PUNCT
dti-1378	347	9	gamma	gamma	NOUN
dti-1378	347	10	complex	complex	NOUN
dti-1378	347	11	might	might	AUX
dti-1378	347	12	influence	influence	VERB
dti-1378	347	13	the	the	DET
dti-1378	347	14	conformation	conformation	NOUN
dti-1378	347	15	changes	change	NOUN
dti-1378	347	16	exhibited	exhibit	VERB
dti-1378	347	17	by	by	ADP
dti-1378	347	18	both	both	DET
dti-1378	347	19	switches	switch	NOUN
dti-1378	347	20	,	,	PUNCT
dti-1378	347	21	which	which	PRON
dti-1378	347	22	could	could	AUX
dti-1378	347	23	affect	affect	VERB
dti-1378	347	24	adenylyl	adenylyl	ADJ
dti-1378	347	25	cyclase	cyclase	NOUN
dti-1378	347	26	activity	activity	NOUN
dti-1378	347	27	.	.	PUNCT
dti-1378	348	1	the	the	DET
dti-1378	348	2	goloco	goloco	ADJ
dti-1378	348	3	binding	bind	VERB
dti-1378	348	4	site	site	NOUN
dti-1378	348	5	is	be	AUX
dti-1378	348	6	known	know	VERB
dti-1378	348	7	to	to	PART
dti-1378	348	8	act	act	VERB
dti-1378	348	9	as	as	ADP
dti-1378	348	10	a	a	DET
dti-1378	348	11	guanine	guanine	NOUN
dti-1378	348	12	nucleotide	nucleotide	NOUN
dti-1378	348	13	dissociation	dissociation	NOUN
dti-1378	348	14	inhibitor	inhibitor	NOUN
dti-1378	348	15	(	(	PUNCT
dti-1378	348	16	gdi),59	gdi),59	PROPN
dti-1378	348	17	and	and	CCONJ
dti-1378	348	18	this	this	PRON
dti-1378	348	19	could	could	AUX
dti-1378	348	20	account	account	VERB
dti-1378	348	21	for	for	ADP
dti-1378	348	22	how	how	SCONJ
dti-1378	348	23	it	it	PRON
dti-1378	348	24	might	might	AUX
dti-1378	348	25	inhibit	inhibit	VERB
dti-1378	348	26	adenylyl	adenylyl	ADJ
dti-1378	348	27	cyclase	cyclase	NOUN
dti-1378	348	28	activity	activity	NOUN
dti-1378	348	29	.	.	PUNCT
dti-1378	349	1	the	the	DET
dti-1378	349	2	beta	beta	NOUN
dti-1378	349	3	-	-	PUNCT
dti-1378	349	4	gamma	gamma	NOUN
dti-1378	349	5	complex	complex	ADJ
dti-1378	349	6	interaction	interaction	NOUN
dti-1378	349	7	site	site	NOUN
dti-1378	349	8	shares	share	NOUN
dti-1378	349	9	conserved	conserve	VERB
dti-1378	349	10	residues	residue	NOUN
dti-1378	349	11	with	with	ADP
dti-1378	349	12	many	many	ADJ
dti-1378	349	13	other	other	ADJ
dti-1378	349	14	domains	domain	NOUN
dti-1378	349	15	(	(	PUNCT
dti-1378	349	16	table	table	NOUN
dti-1378	349	17	5	5	NUM
dti-1378	349	18	)	)	PUNCT
dti-1378	349	19	.	.	PUNCT
dti-1378	350	1	its	its	PRON
dti-1378	350	2	functions	function	NOUN
dti-1378	350	3	had	have	AUX
dti-1378	350	4	been	be	AUX
dti-1378	350	5	extensively	extensively	ADV
dti-1378	350	6	covered	cover	VERB
dti-1378	350	7	in	in	ADP
dti-1378	350	8	the	the	DET
dti-1378	350	9	sections	section	NOUN
dti-1378	350	10	above	above	ADV
dti-1378	350	11	regarding	regard	VERB
dti-1378	350	12	how	how	SCONJ
dti-1378	350	13	it	it	PRON
dti-1378	350	14	might	might	AUX
dti-1378	350	15	influence	influence	VERB
dti-1378	350	16	the	the	DET
dti-1378	350	17	activity	activity	NOUN
dti-1378	350	18	of	of	ADP
dti-1378	350	19	the	the	DET
dti-1378	350	20	other	other	ADJ
dti-1378	350	21	domains	domain	NOUN
dti-1378	350	22	together	together	ADV
dti-1378	350	23	with	with	ADP
dti-1378	350	24	the	the	DET
dti-1378	350	25	goloco	goloco	ADJ
dti-1378	350	26	motif	motif	NOUN
dti-1378	350	27	binding	bind	VERB
dti-1378	350	28	site	site	NOUN
dti-1378	350	29	.	.	PUNCT
dti-1378	351	1	the	the	DET
dti-1378	351	2	binding	binding	NOUN
dti-1378	351	3	of	of	ADP
dti-1378	351	4	extracellular	extracellular	ADJ
dti-1378	351	5	hormone	hormone	NOUN
dti-1378	351	6	(	(	PUNCT
dti-1378	351	7	5ht	5ht	NOUN
dti-1378	351	8	)	)	PUNCT
dti-1378	351	9	on	on	ADP
dti-1378	351	10	the	the	DET
dti-1378	351	11	s.	s.	PROPN
dti-1378	351	12	mansoni	mansoni	PROPN
dti-1378	351	13	serotonin	serotonin	NOUN
dti-1378	351	14	receptor	receptor	NOUN
dti-1378	351	15	(	(	PUNCT
dti-1378	351	16	smp_126730	smp_126730	NUM
dti-1378	351	17	)	)	PUNCT
dti-1378	351	18	initiates	initiate	VERB
dti-1378	351	19	the	the	DET
dti-1378	351	20	ejection	ejection	NOUN
dti-1378	351	21	of	of	ADP
dti-1378	351	22	gdp	gdp	NOUN
dti-1378	351	23	from	from	ADP
dti-1378	351	24	the	the	DET
dti-1378	351	25	g	g	NOUN
dti-1378	351	26	-	-	PUNCT
dti-1378	351	27	alpha	alpha	NOUN
dti-1378	351	28	subunit	subunit	NOUN
dti-1378	351	29	and	and	CCONJ
dti-1378	351	30	initiates	initiate	VERB
dti-1378	351	31	the	the	DET
dti-1378	351	32	binding	binding	NOUN
dti-1378	351	33	of	of	ADP
dti-1378	351	34	gtp	gtp	NOUN
dti-1378	351	35	to	to	ADP
dti-1378	351	36	the	the	DET
dti-1378	351	37	g	g	NOUN
dti-1378	351	38	-	-	PUNCT
dti-1378	351	39	alpha	alpha	NOUN
dti-1378	351	40	subunit.24	subunit.24	NOUN
dti-1378	351	41	this	this	DET
dti-1378	351	42	binding	bind	VERB
dti-1378	351	43	causes	cause	VERB
dti-1378	351	44	the	the	DET
dti-1378	351	45	disassociation	disassociation	NOUN
dti-1378	351	46	of	of	ADP
dti-1378	351	47	g	g	NOUN
dti-1378	351	48	-	-	PUNCT
dti-1378	351	49	alpha	alpha	NOUN
dti-1378	351	50	subunit	subunit	NOUN
dti-1378	351	51	from	from	ADP
dti-1378	351	52	the	the	DET
dti-1378	351	53	galpha/	galpha/	PROPN
dti-1378	351	54	beta	beta	NOUN
dti-1378	351	55	-	-	PUNCT
dti-1378	351	56	gamma	gamma	NOUN
dti-1378	351	57	complex	complex	NOUN
dti-1378	351	58	.	.	PUNCT
dti-1378	352	1	within	within	ADP
dti-1378	352	2	the	the	DET
dti-1378	352	3	protein	protein	NOUN
dti-1378	352	4	folded	fold	VERB
dti-1378	352	5	structure	structure	NOUN
dti-1378	352	6	the	the	DET
dti-1378	352	7	beta	beta	NOUN
dti-1378	352	8	-	-	PUNCT
dti-1378	352	9	gamma	gamma	NOUN
dti-1378	352	10	complex	complex	ADJ
dti-1378	352	11	site	site	NOUN
dti-1378	352	12	(	(	PUNCT
dti-1378	352	13	green	green	NOUN
dti-1378	352	14	)	)	PUNCT
dti-1378	352	15	is	be	AUX
dti-1378	352	16	positioned	position	VERB
dti-1378	352	17	on	on	ADP
dti-1378	352	18	the	the	DET
dti-1378	352	19	surface	surface	NOUN
dti-1378	352	20	,	,	PUNCT
dti-1378	352	21	suggesting	suggest	VERB
dti-1378	352	22	that	that	SCONJ
dti-1378	352	23	the	the	DET
dti-1378	352	24	beta	beta	NOUN
dti-1378	352	25	-	-	PUNCT
dti-1378	352	26	gamma	gamma	NOUN
dti-1378	352	27	complex	complex	NOUN
dti-1378	352	28	is	be	AUX
dti-1378	352	29	also	also	ADV
dti-1378	352	30	in	in	ADP
dti-1378	352	31	close	close	ADJ
dti-1378	352	32	proximity	proximity	NOUN
dti-1378	352	33	to	to	ADP
dti-1378	352	34	the	the	DET
dti-1378	352	35	location	location	NOUN
dti-1378	352	36	of	of	ADP
dti-1378	352	37	switch	switch	NOUN
dti-1378	352	38	i	i	PRON
dti-1378	352	39	and	and	CCONJ
dti-1378	352	40	switch	switch	VERB
dti-1378	352	41	ii	ii	PROPN
dti-1378	352	42	,	,	PUNCT
dti-1378	352	43	where	where	SCONJ
dti-1378	352	44	it	it	PRON
dti-1378	352	45	might	might	AUX
dti-1378	352	46	influence	influence	VERB
dti-1378	352	47	their	their	PRON
dti-1378	352	48	functions	function	NOUN
dti-1378	352	49	.	.	PUNCT
dti-1378	353	1	this	this	DET
dti-1378	353	2	closeness	closeness	NOUN
dti-1378	353	3	might	might	AUX
dti-1378	353	4	help	help	VERB
dti-1378	353	5	both	both	CCONJ
dti-1378	353	6	the	the	DET
dti-1378	353	7	beta	beta	NOUN
dti-1378	353	8	-	-	PUNCT
dti-1378	353	9	gamma	gamma	NOUN
dti-1378	353	10	complex	complex	NOUN
dti-1378	353	11	and	and	CCONJ
dti-1378	353	12	the	the	DET
dti-1378	353	13	goloco	goloco	NOUN
dti-1378	353	14	sites	site	NOUN
dti-1378	353	15	to	to	PART
dti-1378	353	16	influence	influence	VERB
dti-1378	353	17	the	the	DET
dti-1378	353	18	activity	activity	NOUN
dti-1378	353	19	of	of	ADP
dti-1378	353	20	both	both	DET
dti-1378	353	21	switches	switch	NOUN
dti-1378	353	22	through	through	ADP
dti-1378	353	23	their	their	PRON
dti-1378	353	24	shared	share	VERB
dti-1378	353	25	residues	residue	NOUN
dti-1378	353	26	.	.	PUNCT
dti-1378	354	1	the	the	DET
dti-1378	354	2	goloco	goloco	NOUN
dti-1378	354	3	binding	bind	VERB
dti-1378	354	4	site	site	NOUN
dti-1378	354	5	(	(	PUNCT
dti-1378	354	6	black	black	NOUN
dti-1378	354	7	)	)	PUNCT
dti-1378	354	8	has	have	VERB
dti-1378	354	9	residues	residue	NOUN
dti-1378	354	10	located	locate	VERB
dti-1378	354	11	on	on	ADP
dti-1378	354	12	the	the	DET
dti-1378	354	13	helices	helix	NOUN
dti-1378	354	14	and	and	CCONJ
dti-1378	354	15	the	the	DET
dti-1378	354	16	loops	loop	NOUN
dti-1378	354	17	(	(	PUNCT
dti-1378	354	18	fig	fig	NOUN
dti-1378	354	19	.	.	PUNCT
dti-1378	354	20	9a	9a	NOUN
dti-1378	354	21	)	)	PUNCT
dti-1378	354	22	.	.	PUNCT
dti-1378	355	1	it	it	PRON
dti-1378	355	2	is	be	AUX
dti-1378	355	3	situated	situate	VERB
dti-1378	355	4	in	in	ADP
dti-1378	355	5	close	close	ADJ
dti-1378	355	6	proximity	proximity	NOUN
dti-1378	355	7	to	to	ADP
dti-1378	355	8	the	the	DET
dti-1378	355	9	location	location	NOUN
dti-1378	355	10	of	of	ADP
dti-1378	355	11	switch	switch	NOUN
dti-1378	355	12	i	i	PRON
dti-1378	355	13	,	,	PUNCT
dti-1378	355	14	switch	switch	VERB
dti-1378	355	15	ii	ii	PROPN
dti-1378	355	16	and	and	CCONJ
dti-1378	355	17	the	the	DET
dti-1378	355	18	beta	beta	NOUN
dti-1378	355	19	-	-	PUNCT
dti-1378	355	20	gamma	gamma	NOUN
dti-1378	355	21	binding	bind	VERB
dti-1378	355	22	site	site	NOUN
dti-1378	355	23	(	(	PUNCT
dti-1378	355	24	fig	fig	NOUN
dti-1378	355	25	.	.	PUNCT
dti-1378	356	1	9b	9b	NUM
dti-1378	356	2	)	)	PUNCT
dti-1378	356	3	,	,	PUNCT
dti-1378	357	1	http://www.la-press.com	http://www.la-press.com	X
dti-1378	357	2	drug	drug	NOUN
dti-1378	357	3	target	target	NOUN
dti-1378	357	4	features	feature	NOUN
dti-1378	357	5	of	of	ADP
dti-1378	357	6	schistosoma	schistosoma	ADJ
dti-1378	357	7	adenylyl	adenylyl	NOUN
dti-1378	357	8	cyclase	cyclase	NOUN
dti-1378	357	9	activity	activity	NOUN
dti-1378	357	10	drug	drug	NOUN
dti-1378	357	11	target	target	NOUN
dti-1378	357	12	insights	insight	NOUN
dti-1378	357	13	2012:6	2012:6	NUM
dti-1378	357	14	55	55	NUM
dti-1378	357	15	where	where	SCONJ
dti-1378	357	16	it	it	PRON
dti-1378	357	17	might	might	AUX
dti-1378	357	18	influence	influence	VERB
dti-1378	357	19	their	their	PRON
dti-1378	357	20	activities	activity	NOUN
dti-1378	357	21	independently	independently	ADV
dti-1378	357	22	due	due	ADJ
dti-1378	357	23	their	their	PRON
dti-1378	357	24	common	common	ADJ
dti-1378	357	25	shared	share	VERB
dti-1378	357	26	residues	residue	NOUN
dti-1378	357	27	,	,	PUNCT
dti-1378	357	28	as	as	SCONJ
dti-1378	357	29	explained	explain	VERB
dti-1378	357	30	above	above	ADV
dti-1378	357	31	.	.	PUNCT
dti-1378	358	1	the	the	DET
dti-1378	358	2	goloco	goloco	NOUN
dti-1378	358	3	binding	bind	VERB
dti-1378	358	4	site	site	NOUN
dti-1378	358	5	also	also	ADV
dti-1378	358	6	shares	share	VERB
dti-1378	358	7	conserved	conserve	VERB
dti-1378	358	8	residues	residue	NOUN
dti-1378	358	9	with	with	ADP
dti-1378	358	10	gtp	gtp	PROPN
dti-1378	358	11	/	/	SYM
dti-1378	358	12	mg2	mg2	PROPN
dti-1378	358	13	+	+	NOUN
dti-1378	358	14	ion	ion	NOUN
dti-1378	358	15	complex	complex	NOUN
dti-1378	358	16	site	site	NOUN
dti-1378	358	17	and	and	CCONJ
dti-1378	358	18	g3	g3	PROPN
dti-1378	358	19	box	box	NOUN
dti-1378	358	20	motif	motif	NOUN
dti-1378	358	21	.	.	PUNCT
dti-1378	359	1	the	the	DET
dti-1378	359	2	goloco	goloco	ADJ
dti-1378	359	3	binding	bind	VERB
dti-1378	359	4	site	site	NOUN
dti-1378	359	5	is	be	AUX
dti-1378	359	6	also	also	ADV
dti-1378	359	7	known	know	VERB
dti-1378	359	8	as	as	ADP
dti-1378	359	9	the	the	DET
dti-1378	359	10	g	g	PROPN
dti-1378	359	11	protein	protein	NOUN
dti-1378	359	12	regulatory	regulatory	ADJ
dti-1378	359	13	(	(	PUNCT
dti-1378	359	14	gpr	gpr	PROPN
dti-1378	359	15	)	)	PUNCT
dti-1378	359	16	motif,60	motif,60	NOUN
dti-1378	359	17	and	and	CCONJ
dti-1378	359	18	it	it	PRON
dti-1378	359	19	is	be	AUX
dti-1378	359	20	known	know	VERB
dti-1378	359	21	to	to	PART
dti-1378	359	22	prevent	prevent	VERB
dti-1378	359	23	the	the	DET
dti-1378	359	24	spontaneous	spontaneous	ADJ
dti-1378	359	25	release	release	NOUN
dti-1378	359	26	of	of	ADP
dti-1378	359	27	gdp	gdp	NOUN
dti-1378	359	28	by	by	ADP
dti-1378	359	29	gαs	gαs	PROPN
dti-1378	359	30	,	,	PUNCT
dti-1378	359	31	thus	thus	ADV
dti-1378	359	32	acting	act	VERB
dti-1378	359	33	as	as	ADP
dti-1378	359	34	a	a	DET
dti-1378	359	35	guanine	guanine	NOUN
dti-1378	359	36	nucleotide	nucleotide	NOUN
dti-1378	359	37	dissociation	dissociation	NOUN
dti-1378	359	38	inhibitor	inhibitor	NOUN
dti-1378	359	39	(	(	PUNCT
dti-1378	359	40	gdi).59	gdi).59	NOUN
dti-1378	359	41	we	we	PRON
dti-1378	359	42	have	have	AUX
dti-1378	359	43	discussed	discuss	VERB
dti-1378	359	44	in	in	ADP
dti-1378	359	45	the	the	DET
dti-1378	359	46	previous	previous	ADJ
dti-1378	359	47	sections	section	NOUN
dti-1378	359	48	how	how	SCONJ
dti-1378	359	49	this	this	DET
dti-1378	359	50	domain	domain	NOUN
dti-1378	359	51	influences	influence	VERB
dti-1378	359	52	the	the	DET
dti-1378	359	53	activities	activity	NOUN
dti-1378	359	54	of	of	ADP
dti-1378	359	55	other	other	ADJ
dti-1378	359	56	domains	domain	NOUN
dti-1378	359	57	with	with	ADP
dti-1378	359	58	shared	share	VERB
dti-1378	359	59	residues	residue	NOUN
dti-1378	359	60	,	,	PUNCT
dti-1378	359	61	and	and	CCONJ
dti-1378	359	62	we	we	PRON
dti-1378	359	63	shall	shall	AUX
dti-1378	359	64	look	look	VERB
dti-1378	359	65	at	at	ADP
dti-1378	359	66	its	its	PRON
dti-1378	359	67	impact	impact	NOUN
dti-1378	359	68	with	with	ADP
dti-1378	359	69	the	the	DET
dti-1378	359	70	rest	rest	NOUN
dti-1378	359	71	of	of	ADP
dti-1378	359	72	the	the	DET
dti-1378	359	73	uncovered	uncovered	ADJ
dti-1378	359	74	individual	individual	ADJ
dti-1378	359	75	domains	domain	NOUN
dti-1378	359	76	.	.	PUNCT
dti-1378	360	1	putative	putative	ADJ
dti-1378	360	2	receptor	receptor	NOUN
dti-1378	360	3	,	,	PUNCT
dti-1378	360	4	switch	switch	VERB
dti-1378	360	5	i	i	PRON
dti-1378	360	6	and	and	CCONJ
dti-1378	360	7	switch	switch	VERB
dti-1378	360	8	ii	ii	NOUN
dti-1378	360	9	interaction	interaction	NOUN
dti-1378	360	10	sites	site	NOUN
dti-1378	360	11	on	on	ADP
dti-1378	360	12	the	the	DET
dti-1378	360	13	protein	protein	NOUN
dti-1378	360	14	folded	fold	VERB
dti-1378	360	15	structure	structure	NOUN
dti-1378	360	16	,	,	PUNCT
dti-1378	360	17	the	the	DET
dti-1378	360	18	receptor	receptor	NOUN
dti-1378	360	19	binding	bind	VERB
dti-1378	360	20	site	site	NOUN
dti-1378	360	21	stretches	stretch	VERB
dti-1378	360	22	from	from	ADP
dti-1378	360	23	within	within	ADP
dti-1378	360	24	the	the	DET
dti-1378	360	25	inner	inner	ADJ
dti-1378	360	26	active	active	ADJ
dti-1378	360	27	cavity	cavity	NOUN
dti-1378	360	28	were	be	AUX
dti-1378	360	29	it	it	PRON
dti-1378	360	30	shares	share	VERB
dti-1378	360	31	two	two	NUM
dti-1378	360	32	residues	residue	NOUN
dti-1378	360	33	with	with	ADP
dti-1378	360	34	the	the	DET
dti-1378	360	35	gtp	gtp	PROPN
dti-1378	360	36	/	/	SYM
dti-1378	360	37	mg2	mg2	PROPN
dti-1378	360	38	+	+	NOUN
dti-1378	360	39	ion	ion	NOUN
dti-1378	360	40	complex	complex	ADJ
dti-1378	360	41	binding	bind	VERB
dti-1378	360	42	site	site	NOUN
dti-1378	360	43	at	at	ADP
dti-1378	360	44	cys350	cys350	PROPN
dti-1378	360	45	and	and	CCONJ
dti-1378	360	46	ala351	ala351	NOUN
dti-1378	360	47	to	to	ADP
dti-1378	360	48	the	the	DET
dti-1378	360	49	surface	surface	NOUN
dti-1378	360	50	of	of	ADP
dti-1378	360	51	the	the	DET
dti-1378	360	52	protein	protein	NOUN
dti-1378	360	53	(	(	PUNCT
dti-1378	360	54	fig	fig	NOUN
dti-1378	360	55	.	.	PUNCT
dti-1378	360	56	10b	10b	NOUN
dti-1378	360	57	)	)	PUNCT
dti-1378	360	58	.	.	PUNCT
dti-1378	361	1	it	it	PRON
dti-1378	361	2	also	also	ADV
dti-1378	361	3	shares	share	VERB
dti-1378	361	4	all	all	DET
dti-1378	361	5	3	3	NUM
dti-1378	361	6	conserved	conserved	ADJ
dti-1378	361	7	residues	residue	NOUN
dti-1378	361	8	(	(	PUNCT
dti-1378	361	9	cys350	cys350	NOUN
dti-1378	361	10	,	,	PUNCT
dti-1378	361	11	ala351	ala351	NOUN
dti-1378	361	12	and	and	CCONJ
dti-1378	361	13	val352	val352	PROPN
dti-1378	361	14	)	)	PUNCT
dti-1378	361	15	found	find	VERB
dti-1378	361	16	in	in	ADP
dti-1378	361	17	g5	g5	PROPN
dti-1378	361	18	box	box	NOUN
dti-1378	361	19	motif	motif	NOUN
dti-1378	361	20	.	.	PUNCT
dti-1378	362	1	hence	hence	ADV
dti-1378	362	2	,	,	PUNCT
dti-1378	362	3	the	the	DET
dti-1378	362	4	g5	g5	PROPN
dti-1378	362	5	box	box	NOUN
dti-1378	362	6	motif	motif	NOUN
dti-1378	362	7	is	be	AUX
dti-1378	362	8	part	part	NOUN
dti-1378	362	9	of	of	ADP
dti-1378	362	10	the	the	DET
dti-1378	362	11	putative	putative	ADJ
dti-1378	362	12	receptor	receptor	NOUN
dti-1378	362	13	binding	bind	VERB
dti-1378	362	14	site	site	NOUN
dti-1378	362	15	and	and	CCONJ
dti-1378	362	16	functions	function	NOUN
dti-1378	362	17	as	as	ADP
dti-1378	362	18	a	a	DET
dti-1378	362	19	buttress	buttress	ADJ
dti-1378	362	20	factor	factor	NOUN
dti-1378	362	21	for	for	ADP
dti-1378	362	22	the	the	DET
dti-1378	362	23	guanine	guanine	NOUN
dti-1378	362	24	base	base	PROPN
dti-1378	362	25	recognition	recognition	NOUN
dti-1378	362	26	site	site	NOUN
dti-1378	362	27	.	.	PUNCT
dti-1378	363	1	ala351	ala351	NOUN
dti-1378	363	2	could	could	AUX
dti-1378	363	3	be	be	AUX
dti-1378	363	4	contributing	contribute	VERB
dti-1378	363	5	to	to	ADP
dti-1378	363	6	this	this	DET
dti-1378	363	7	buttress	buttress	ADJ
dti-1378	363	8	factor	factor	NOUN
dti-1378	363	9	function	function	NOUN
dti-1378	363	10	due	due	ADP
dti-1378	363	11	to	to	ADP
dti-1378	363	12	its	its	PRON
dti-1378	363	13	presence	presence	NOUN
dti-1378	363	14	at	at	ADP
dti-1378	363	15	the	the	DET
dti-1378	363	16	gtp	gtp	PROPN
dti-1378	363	17	/	/	SYM
dti-1378	363	18	mg2	mg2	PROPN
dti-1378	363	19	+	+	NOUN
dti-1378	363	20	ion	ion	NOUN
dti-1378	363	21	complex	complex	ADJ
dti-1378	363	22	binding	bind	VERB
dti-1378	363	23	site	site	NOUN
dti-1378	363	24	.	.	PUNCT
dti-1378	364	1	the	the	DET
dti-1378	364	2	structural	structural	ADJ
dti-1378	364	3	conformity	conformity	NOUN
dti-1378	364	4	of	of	ADP
dti-1378	364	5	the	the	DET
dti-1378	364	6	putative	putative	ADJ
dti-1378	364	7	receptor	receptor	NOUN
dti-1378	364	8	might	might	AUX
dti-1378	364	9	be	be	AUX
dti-1378	364	10	contributing	contribute	VERB
dti-1378	364	11	to	to	ADP
dti-1378	364	12	the	the	DET
dti-1378	364	13	binding	bind	VERB
dti-1378	364	14	stability	stability	NOUN
dti-1378	364	15	of	of	ADP
dti-1378	364	16	the	the	DET
dti-1378	364	17	gαs	gαs	PROPN
dti-1378	364	18	(	(	PUNCT
dti-1378	364	19	smp_059340.1	smp_059340.1	PROPN
dti-1378	364	20	)	)	PUNCT
dti-1378	364	21	protein	protein	NOUN
dti-1378	364	22	,	,	PUNCT
dti-1378	364	23	the	the	DET
dti-1378	364	24	gtp	gtp	NOUN
dti-1378	364	25	molecule	molecule	NOUN
dti-1378	364	26	and	and	CCONJ
dti-1378	364	27	to	to	ADP
dti-1378	364	28	the	the	DET
dti-1378	364	29	serotonin	serotonin	NOUN
dti-1378	364	30	receptor	receptor	NOUN
dti-1378	364	31	(	(	PUNCT
dti-1378	364	32	smp_126730	smp_126730	NUM
dti-1378	364	33	)	)	PUNCT
dti-1378	364	34	.	.	PUNCT
dti-1378	365	1	considering	consider	VERB
dti-1378	365	2	the	the	DET
dti-1378	365	3	function	function	NOUN
dti-1378	365	4	,	,	PUNCT
dti-1378	365	5	conserved	conserve	VERB
dti-1378	365	6	shared	share	VERB
dti-1378	365	7	residues	residue	NOUN
dti-1378	365	8	and	and	CCONJ
dti-1378	365	9	location	location	NOUN
dti-1378	365	10	of	of	ADP
dti-1378	365	11	the	the	DET
dti-1378	365	12	putative	putative	ADJ
dti-1378	365	13	receptor	receptor	NOUN
dti-1378	365	14	binding	bind	VERB
dti-1378	365	15	site	site	NOUN
dti-1378	365	16	,	,	PUNCT
dti-1378	365	17	this	this	DET
dti-1378	365	18	domain	domain	NOUN
dti-1378	365	19	can	can	AUX
dti-1378	365	20	be	be	AUX
dti-1378	365	21	very	very	ADV
dti-1378	365	22	crucial	crucial	ADJ
dti-1378	365	23	to	to	ADP
dti-1378	365	24	the	the	DET
dti-1378	365	25	continuous	continuous	ADJ
dti-1378	365	26	flow	flow	NOUN
dti-1378	365	27	of	of	ADP
dti-1378	365	28	signal	signal	NOUN
dti-1378	365	29	in	in	ADP
dti-1378	365	30	the	the	DET
dti-1378	365	31	adenylyl	adenylyl	NOUN
dti-1378	365	32	cyclase	cyclase	NOUN
dti-1378	365	33	pathway	pathway	NOUN
dti-1378	365	34	.	.	PUNCT
dti-1378	366	1	switch	switch	VERB
dti-1378	366	2	i	i	PRON
dti-1378	366	3	and	and	CCONJ
dti-1378	366	4	switch	switch	VERB
dti-1378	366	5	ii	ii	PROPN
dti-1378	366	6	are	be	AUX
dti-1378	366	7	both	both	CCONJ
dti-1378	366	8	molecular	molecular	ADJ
dti-1378	366	9	switches	switch	NOUN
dti-1378	366	10	cycling	cycling	NOUN
dti-1378	366	11	between	between	ADP
dti-1378	366	12	an	an	DET
dti-1378	366	13	active	active	ADJ
dti-1378	366	14	state	state	NOUN
dti-1378	366	15	(	(	PUNCT
dti-1378	366	16	gtp	gtp	NOUN
dti-1378	366	17	bound	bind	VERB
dti-1378	366	18	)	)	PUNCT
dti-1378	366	19	and	and	CCONJ
dti-1378	366	20	an	an	DET
dti-1378	366	21	inactive	inactive	ADJ
dti-1378	366	22	state	state	NOUN
dti-1378	366	23	(	(	PUNCT
dti-1378	366	24	gdp	gdp	NOUN
dti-1378	366	25	bound	bind	VERB
dti-1378	366	26	)	)	PUNCT
dti-1378	366	27	,	,	PUNCT
dti-1378	366	28	and	and	CCONJ
dti-1378	366	29	switch	switch	VERB
dti-1378	366	30	i	i	PRON
dti-1378	366	31	is	be	AUX
dti-1378	366	32	shorter	short	ADJ
dti-1378	366	33	than	than	SCONJ
dti-1378	366	34	switch	switch	VERB
dti-1378	366	35	ii	ii	PROPN
dti-1378	366	36	by	by	ADP
dti-1378	366	37	8	8	NUM
dti-1378	366	38	residues	residue	NOUN
dti-1378	366	39	.	.	PUNCT
dti-1378	367	1	these	these	DET
dti-1378	367	2	regions	region	NOUN
dti-1378	367	3	share	share	VERB
dti-1378	367	4	conserved	conserve	VERB
dti-1378	367	5	residues	residue	NOUN
dti-1378	367	6	with	with	ADP
dti-1378	367	7	the	the	DET
dti-1378	367	8	gtp	gtp	PROPN
dti-1378	367	9	/	/	SYM
dti-1378	367	10	mg2	mg2	PROPN
dti-1378	367	11	+	+	NOUN
dti-1378	367	12	ion	ion	NOUN
dti-1378	367	13	complex	complex	NOUN
dti-1378	367	14	,	,	PUNCT
dti-1378	367	15	adenylyl	adenylyl	NOUN
dti-1378	367	16	cyclase	cyclase	NOUN
dti-1378	367	17	interaction	interaction	NOUN
dti-1378	367	18	site	site	NOUN
dti-1378	367	19	,	,	PUNCT
dti-1378	367	20	beta	beta	NOUN
dti-1378	367	21	-	-	PUNCT
dti-1378	367	22	gamma	gamma	NOUN
dti-1378	367	23	complex	complex	NOUN
dti-1378	367	24	,	,	PUNCT
dti-1378	367	25	goloco	goloco	ADJ
dti-1378	367	26	binding	bind	VERB
dti-1378	367	27	site	site	NOUN
dti-1378	367	28	and	and	CCONJ
dti-1378	367	29	the	the	DET
dti-1378	367	30	g2	g2	PROPN
dti-1378	367	31	box	box	NOUN
dti-1378	367	32	motif	motif	NOUN
dti-1378	367	33	as	as	SCONJ
dti-1378	367	34	explained	explain	VERB
dti-1378	367	35	above	above	ADV
dti-1378	367	36	.	.	PUNCT
dti-1378	368	1	in	in	ADP
dti-1378	368	2	switch	switch	NOUN
dti-1378	368	3	i	i	PRON
dti-1378	368	4	,	,	PUNCT
dti-1378	368	5	the	the	DET
dti-1378	368	6	transitional	transitional	ADJ
dti-1378	368	7	conformation	conformation	NOUN
dti-1378	368	8	changes	change	NOUN
dti-1378	368	9	mainly	mainly	ADV
dti-1378	368	10	involve	involve	VERB
dti-1378	368	11	flips	flip	NOUN
dti-1378	368	12	of	of	ADP
dti-1378	368	13	some	some	DET
dti-1378	368	14	peptide	peptide	ADJ
dti-1378	368	15	units	unit	NOUN
dti-1378	368	16	and	and	CCONJ
dti-1378	368	17	reorientation	reorientation	NOUN
dti-1378	368	18	of	of	ADP
dti-1378	368	19	some	some	DET
dti-1378	368	20	side	side	NOUN
dti-1378	368	21	chains.61,62	chains.61,62	NOUN
dti-1378	368	22	the	the	DET
dti-1378	368	23	key	key	ADJ
dti-1378	368	24	residue	residue	NOUN
dti-1378	368	25	could	could	AUX
dti-1378	368	26	be	be	AUX
dti-1378	368	27	the	the	DET
dti-1378	368	28	thr188	thr188	NOUN
dti-1378	368	29	that	that	PRON
dti-1378	368	30	coordinates	coordinate	VERB
dti-1378	368	31	the	the	DET
dti-1378	368	32	magnesium	magnesium	NOUN
dti-1378	368	33	ions	ion	NOUN
dti-1378	368	34	of	of	ADP
dti-1378	368	35	the	the	DET
dti-1378	368	36	mg	mg	PROPN
dti-1378	368	37	-	-	PUNCT
dti-1378	368	38	gtp	gtp	NOUN
dti-1378	368	39	complex	complex	NOUN
dti-1378	368	40	,	,	PUNCT
dti-1378	368	41	which	which	PRON
dti-1378	368	42	can	can	AUX
dti-1378	368	43	thus	thus	ADV
dti-1378	368	44	sense	sense	VERB
dti-1378	368	45	the	the	DET
dti-1378	368	46	presence	presence	NOUN
dti-1378	368	47	of	of	ADP
dti-1378	368	48	the	the	DET
dti-1378	368	49	γ	γ	PROPN
dti-1378	368	50	phosphate.63	phosphate.63	PROPN
dti-1378	368	51	therefore	therefore	ADV
dti-1378	368	52	,	,	PUNCT
dti-1378	368	53	the	the	DET
dti-1378	368	54	conformation	conformation	NOUN
dti-1378	368	55	transition	transition	NOUN
dti-1378	368	56	in	in	ADP
dti-1378	368	57	the	the	DET
dti-1378	368	58	switch	switch	NOUN
dti-1378	368	59	i	i	PRON
dti-1378	368	60	region	region	NOUN
dti-1378	368	61	is	be	AUX
dti-1378	368	62	manifested	manifest	VERB
dti-1378	368	63	in	in	ADP
dti-1378	368	64	a	a	DET
dti-1378	368	65	reorientation	reorientation	NOUN
dti-1378	368	66	of	of	ADP
dti-1378	368	67	the	the	DET
dti-1378	368	68	conserved	conserved	ADJ
dti-1378	368	69	residue	residue	NOUN
dti-1378	368	70	(	(	PUNCT
dti-1378	368	71	thr188	thr188	PROPN
dti-1378	368	72	)	)	PUNCT
dti-1378	368	73	in	in	ADP
dti-1378	368	74	both	both	CCONJ
dti-1378	368	75	the	the	DET
dti-1378	368	76	mg2	mg2	PROPN
dti-1378	368	77	+	+	SYM
dti-1378	368	78	ion	ion	NOUN
dti-1378	368	79	ligand	ligand	NOUN
dti-1378	368	80	and	and	CCONJ
dti-1378	368	81	the	the	DET
dti-1378	368	82	g2	g2	PROPN
dti-1378	368	83	box	box	NOUN
dti-1378	368	84	motif	motif	NOUN
dti-1378	368	85	(	(	PUNCT
dti-1378	368	86	thr188	thr188	PROPN
dti-1378	368	87	)	)	PUNCT
dti-1378	368	88	,	,	PUNCT
dti-1378	368	89	which	which	PRON
dti-1378	368	90	is	be	AUX
dti-1378	368	91	also	also	ADV
dti-1378	368	92	an	an	DET
dti-1378	368	93	integral	integral	ADJ
dti-1378	368	94	residue	residue	NOUN
dti-1378	368	95	of	of	ADP
dti-1378	368	96	the	the	DET
dti-1378	368	97	switch	switch	NOUN
dti-1378	368	98	i	i	PROPN
dti-1378	368	99	region	region	NOUN
dti-1378	368	100	.	.	PUNCT
dti-1378	369	1	the	the	DET
dti-1378	369	2	switch	switch	NOUN
dti-1378	369	3	i	i	PRON
dti-1378	369	4	region	region	NOUN
dti-1378	369	5	has	have	AUX
dti-1378	369	6	also	also	ADV
dti-1378	369	7	been	be	AUX
dti-1378	369	8	identified	identify	VERB
dti-1378	369	9	as	as	ADP
dti-1378	369	10	the	the	DET
dti-1378	369	11	gap	gap	NOUN
dti-1378	369	12	(	(	PUNCT
dti-1378	369	13	gtp	gtp	NOUN
dti-1378	369	14	activation	activation	NOUN
dti-1378	369	15	protein	protein	NOUN
dti-1378	369	16	)	)	PUNCT
dti-1378	369	17	binding	bind	VERB
dti-1378	369	18	region.64,65	region.64,65	NOUN
dti-1378	369	19	this	this	DET
dti-1378	369	20	region	region	NOUN
dti-1378	369	21	may	may	AUX
dti-1378	369	22	be	be	AUX
dti-1378	369	23	responsible	responsible	ADJ
dti-1378	369	24	for	for	ADP
dti-1378	369	25	the	the	DET
dti-1378	369	26	tight	tight	ADJ
dti-1378	369	27	coupling	coupling	NOUN
dti-1378	369	28	of	of	ADP
dti-1378	369	29	the	the	DET
dti-1378	369	30	gtp	gtp	PROPN
dti-1378	369	31	/	/	SYM
dti-1378	369	32	mg2	mg2	PROPN
dti-1378	369	33	+	+	NOUN
dti-1378	369	34	ion	ion	NOUN
dti-1378	369	35	complex	complex	NOUN
dti-1378	369	36	through	through	ADP
dti-1378	369	37	their	their	PRON
dti-1378	369	38	shared	share	VERB
dti-1378	369	39	thr188	thr188	NOUN
dti-1378	369	40	residue.56	residue.56	VERB
dti-1378	369	41	as	as	SCONJ
dti-1378	369	42	explained	explain	VERB
dti-1378	369	43	in	in	ADP
dti-1378	369	44	the	the	DET
dti-1378	369	45	previous	previous	ADJ
dti-1378	369	46	paragraphs	paragraph	NOUN
dti-1378	369	47	,	,	PUNCT
dti-1378	369	48	the	the	DET
dti-1378	369	49	function	function	NOUN
dti-1378	369	50	of	of	ADP
dti-1378	369	51	the	the	DET
dti-1378	369	52	switch	switch	NOUN
dti-1378	369	53	i	i	PRON
dti-1378	369	54	region	region	NOUN
dti-1378	369	55	during	during	ADP
dti-1378	369	56	conformation	conformation	NOUN
dti-1378	369	57	changes	change	NOUN
dti-1378	369	58	between	between	ADP
dti-1378	369	59	gtp	gtp	NOUN
dti-1378	369	60	and	and	CCONJ
dti-1378	369	61	gdp	gdp	NOUN
dti-1378	369	62	can	can	AUX
dti-1378	369	63	be	be	AUX
dti-1378	369	64	compromised	compromise	VERB
dti-1378	369	65	by	by	ADP
dti-1378	369	66	both	both	CCONJ
dti-1378	369	67	the	the	DET
dti-1378	369	68	beta	beta	NOUN
dti-1378	369	69	-	-	PUNCT
dti-1378	369	70	gamma	gamma	NOUN
dti-1378	369	71	complex	complex	NOUN
dti-1378	369	72	and	and	CCONJ
dti-1378	369	73	the	the	DET
dti-1378	369	74	goloco	goloco	ADJ
dti-1378	369	75	binding	bind	VERB
dti-1378	369	76	sites	site	NOUN
dti-1378	369	77	,	,	PUNCT
dti-1378	369	78	through	through	ADP
dti-1378	369	79	their	their	PRON
dti-1378	369	80	common	common	ADJ
dti-1378	369	81	shared	share	VERB
dti-1378	369	82	conserved	conserve	VERB
dti-1378	369	83	residues	residue	NOUN
dti-1378	369	84	(	(	PUNCT
dti-1378	369	85	table	table	NOUN
dti-1378	369	86	5	5	NUM
dti-1378	369	87	)	)	PUNCT
dti-1378	369	88	.	.	PUNCT
dti-1378	370	1	on	on	ADP
dti-1378	370	2	the	the	DET
dti-1378	370	3	folded	fold	VERB
dti-1378	370	4	protein	protein	NOUN
dti-1378	370	5	structure	structure	NOUN
dti-1378	370	6	,	,	PUNCT
dti-1378	370	7	the	the	DET
dti-1378	370	8	switch	switch	NOUN
dti-1378	370	9	i	i	PRON
dti-1378	370	10	region	region	NOUN
dti-1378	370	11	(	(	PUNCT
dti-1378	370	12	green	green	NOUN
dti-1378	370	13	)	)	PUNCT
dti-1378	370	14	is	be	AUX
dti-1378	370	15	oriented	orient	VERB
dti-1378	370	16	on	on	ADP
dti-1378	370	17	the	the	DET
dti-1378	370	18	surface	surface	NOUN
dti-1378	370	19	,	,	PUNCT
dti-1378	370	20	very	very	ADV
dti-1378	370	21	close	close	ADJ
dti-1378	370	22	to	to	ADP
dti-1378	370	23	the	the	DET
dti-1378	370	24	switch	switch	NOUN
dti-1378	370	25	ii	ii	PROPN
dti-1378	370	26	region	region	NOUN
dti-1378	370	27	(	(	PUNCT
dti-1378	370	28	yellow	yellow	ADJ
dti-1378	370	29	;	;	PUNCT
dti-1378	370	30	fig	fig	NOUN
dti-1378	370	31	.	.	PUNCT
dti-1378	370	32	10b	10b	NOUN
dti-1378	370	33	)	)	PUNCT
dti-1378	370	34	.	.	PUNCT
dti-1378	371	1	as	as	SCONJ
dti-1378	371	2	mentioned	mention	VERB
dti-1378	371	3	above	above	ADV
dti-1378	371	4	,	,	PUNCT
dti-1378	371	5	the	the	DET
dti-1378	371	6	beta	beta	NOUN
dti-1378	371	7	-	-	PUNCT
dti-1378	371	8	gamma	gamma	NOUN
dti-1378	371	9	complex	complex	NOUN
dti-1378	371	10	or	or	CCONJ
dti-1378	371	11	the	the	DET
dti-1378	371	12	goloco	goloco	ADJ
dti-1378	371	13	binding	bind	VERB
dti-1378	371	14	sites	site	NOUN
dti-1378	371	15	share	share	VERB
dti-1378	371	16	common	common	ADJ
dti-1378	371	17	conserved	conserve	VERB
dti-1378	371	18	residues	residue	NOUN
dti-1378	371	19	with	with	ADP
dti-1378	371	20	both	both	DET
dti-1378	371	21	switch	switch	NOUN
dti-1378	371	22	i	i	PRON
dti-1378	371	23	and	and	CCONJ
dti-1378	371	24	switch	switch	VERB
dti-1378	371	25	ii	ii	NOUN
dti-1378	371	26	regions	region	NOUN
dti-1378	371	27	.	.	PUNCT
dti-1378	372	1	therefore	therefore	ADV
dti-1378	372	2	,	,	PUNCT
dti-1378	372	3	this	this	DET
dti-1378	372	4	close	close	ADJ
dti-1378	372	5	proximity	proximity	NOUN
dti-1378	372	6	of	of	ADP
dti-1378	372	7	switch	switch	NOUN
dti-1378	372	8	i	i	PRON
dti-1378	372	9	and	and	CCONJ
dti-1378	372	10	switch	switch	VERB
dti-1378	372	11	ii	ii	PROPN
dti-1378	372	12	region	region	NOUN
dti-1378	372	13	suggests	suggest	VERB
dti-1378	372	14	that	that	SCONJ
dti-1378	372	15	the	the	DET
dti-1378	372	16	conformational	conformational	ADJ
dti-1378	372	17	changes	change	NOUN
dti-1378	372	18	in	in	ADP
dti-1378	372	19	both	both	DET
dti-1378	372	20	switches	switch	NOUN
dti-1378	372	21	might	might	AUX
dti-1378	372	22	be	be	AUX
dti-1378	372	23	coupled	couple	VERB
dti-1378	372	24	with	with	ADP
dti-1378	372	25	,	,	PUNCT
dti-1378	372	26	and	and	CCONJ
dti-1378	372	27	the	the	DET
dti-1378	372	28	functionality	functionality	NOUN
dti-1378	372	29	of	of	ADP
dti-1378	372	30	both	both	DET
dti-1378	372	31	switches	switch	NOUN
dti-1378	372	32	might	might	AUX
dti-1378	372	33	be	be	AUX
dti-1378	372	34	influenced	influence	VERB
dti-1378	372	35	simultaneously	simultaneously	ADV
dti-1378	372	36	by	by	ADP
dti-1378	372	37	,	,	PUNCT
dti-1378	372	38	either	either	CCONJ
dti-1378	372	39	the	the	DET
dti-1378	372	40	beta	beta	NOUN
dti-1378	372	41	-	-	PUNCT
dti-1378	372	42	gamma	gamma	NOUN
dti-1378	372	43	complex	complex	NOUN
dti-1378	372	44	or	or	CCONJ
dti-1378	372	45	the	the	DET
dti-1378	372	46	goloco	goloco	ADJ
dti-1378	372	47	binding	bind	VERB
dti-1378	372	48	sites	site	NOUN
dti-1378	372	49	.	.	PUNCT
dti-1378	373	1	the	the	DET
dti-1378	373	2	switch	switch	NOUN
dti-1378	373	3	ii	ii	PROPN
dti-1378	373	4	shares	share	NOUN
dti-1378	373	5	conserved	conserve	VERB
dti-1378	373	6	residues	residue	NOUN
dti-1378	373	7	with	with	ADP
dti-1378	373	8	the	the	DET
dti-1378	373	9	gtp	gtp	PROPN
dti-1378	373	10	/	/	SYM
dti-1378	373	11	mg2	mg2	PROPN
dti-1378	373	12	+	+	NOUN
dti-1378	373	13	ion	ion	NOUN
dti-1378	373	14	complex	complex	NOUN
dti-1378	373	15	,	,	PUNCT
dti-1378	373	16	adenylyl	adenylyl	NOUN
dti-1378	373	17	cyclase	cyclase	NOUN
dti-1378	373	18	interaction	interaction	NOUN
dti-1378	373	19	site	site	NOUN
dti-1378	373	20	,	,	PUNCT
dti-1378	373	21	beta	beta	NOUN
dti-1378	373	22	-	-	PUNCT
dti-1378	373	23	gamma	gamma	NOUN
dti-1378	373	24	complex	complex	NOUN
dti-1378	373	25	,	,	PUNCT
dti-1378	373	26	goloco	goloco	ADJ
dti-1378	373	27	binding	bind	VERB
dti-1378	373	28	site	site	NOUN
dti-1378	373	29	and	and	CCONJ
dti-1378	373	30	the	the	DET
dti-1378	373	31	g3	g3	PROPN
dti-1378	373	32	box	box	NOUN
dti-1378	373	33	motif	motif	NOUN
dti-1378	373	34	.	.	PUNCT
dti-1378	374	1	it	it	PRON
dti-1378	374	2	was	be	AUX
dti-1378	374	3	deduced	deduce	VERB
dti-1378	374	4	that	that	SCONJ
dti-1378	374	5	both	both	CCONJ
dti-1378	374	6	the	the	DET
dti-1378	374	7	adenylyl	adenylyl	NOUN
dti-1378	374	8	cyclase	cyclase	NOUN
dti-1378	374	9	binding	bind	VERB
dti-1378	374	10	site	site	NOUN
dti-1378	374	11	(	(	PUNCT
dti-1378	374	12	4	4	NUM
dti-1378	374	13	out	out	ADP
dti-1378	374	14	of	of	ADP
dti-1378	374	15	5	5	NUM
dti-1378	374	16	residues	residue	NOUN
dti-1378	374	17	)	)	PUNCT
dti-1378	374	18	and	and	CCONJ
dti-1378	374	19	the	the	DET
dti-1378	374	20	g3	g3	PROPN
dti-1378	374	21	box	box	NOUN
dti-1378	374	22	motif	motif	NOUN
dti-1378	374	23	(	(	PUNCT
dti-1378	374	24	3	3	NUM
dti-1378	374	25	out	out	ADP
dti-1378	374	26	of	of	ADP
dti-1378	374	27	4	4	NUM
dti-1378	374	28	)	)	PUNCT
dti-1378	374	29	residues	residue	NOUN
dti-1378	374	30	are	be	AUX
dti-1378	374	31	completely	completely	ADV
dti-1378	374	32	integrated	integrate	VERB
dti-1378	374	33	into	into	ADP
dti-1378	374	34	the	the	DET
dti-1378	374	35	switch	switch	NOUN
dti-1378	374	36	ii	ii	PROPN
dti-1378	374	37	region	region	NOUN
dti-1378	374	38	in	in	ADP
dti-1378	374	39	terms	term	NOUN
dti-1378	374	40	of	of	ADP
dti-1378	374	41	the	the	DET
dti-1378	374	42	their	their	PRON
dti-1378	374	43	shared	share	VERB
dti-1378	374	44	residues	residue	NOUN
dti-1378	374	45	.	.	PUNCT
dti-1378	375	1	there	there	PRON
dti-1378	375	2	is	be	VERB
dti-1378	375	3	considerable	considerable	ADJ
dti-1378	375	4	conformational	conformational	ADJ
dti-1378	375	5	flexibility	flexibility	NOUN
dti-1378	375	6	in	in	ADP
dti-1378	375	7	this	this	DET
dti-1378	375	8	region	region	NOUN
dti-1378	375	9	,	,	PUNCT
dti-1378	375	10	especially	especially	ADV
dti-1378	375	11	in	in	ADP
dti-1378	375	12	the	the	DET
dti-1378	375	13	gdp	gdp	NOUN
dti-1378	375	14	bound	bind	VERB
dti-1378	375	15	state.61,62	state.61,62	NOUN
dti-1378	375	16	as	as	SCONJ
dti-1378	375	17	mentioned	mention	VERB
dti-1378	375	18	above	above	ADV
dti-1378	375	19	,	,	PUNCT
dti-1378	375	20	the	the	DET
dti-1378	375	21	adenylyl	adenylyl	NOUN
dti-1378	375	22	cyclase	cyclase	NOUN
dti-1378	375	23	binding	bind	VERB
dti-1378	375	24	site	site	NOUN
dti-1378	375	25	may	may	AUX
dti-1378	375	26	be	be	AUX
dti-1378	375	27	contributing	contribute	VERB
dti-1378	375	28	to	to	ADP
dti-1378	375	29	these	these	DET
dti-1378	375	30	conformation	conformation	NOUN
dti-1378	375	31	changes	change	NOUN
dti-1378	375	32	.	.	PUNCT
dti-1378	376	1	the	the	DET
dti-1378	376	2	same	same	ADJ
dti-1378	376	3	plausible	plausible	ADJ
dti-1378	376	4	reason	reason	NOUN
dti-1378	376	5	as	as	SCONJ
dti-1378	376	6	explained	explain	VERB
dti-1378	376	7	above	above	ADV
dti-1378	376	8	for	for	ADP
dti-1378	376	9	the	the	DET
dti-1378	376	10	switch	switch	NOUN
dti-1378	376	11	ii	ii	PROPN
dti-1378	376	12	region	region	NOUN
dti-1378	376	13	could	could	AUX
dti-1378	376	14	be	be	AUX
dti-1378	376	15	the	the	DET
dti-1378	376	16	case	case	NOUN
dti-1378	376	17	here	here	ADV
dti-1378	376	18	—	—	PUNCT
dti-1378	376	19	the	the	DET
dti-1378	376	20	conformational	conformational	ADJ
dti-1378	376	21	changes	change	NOUN
dti-1378	376	22	between	between	ADP
dti-1378	376	23	gtp	gtp	NOUN
dti-1378	376	24	and	and	CCONJ
dti-1378	376	25	gdp	gdp	NOUN
dti-1378	376	26	can	can	AUX
dti-1378	376	27	be	be	AUX
dti-1378	376	28	greatly	greatly	ADV
dti-1378	376	29	hampered	hamper	VERB
dti-1378	376	30	by	by	ADP
dti-1378	376	31	both	both	CCONJ
dti-1378	376	32	the	the	DET
dti-1378	376	33	beta	beta	NOUN
dti-1378	376	34	-	-	PUNCT
dti-1378	376	35	gamma	gamma	NOUN
dti-1378	376	36	complex	complex	NOUN
dti-1378	376	37	and	and	CCONJ
dti-1378	376	38	the	the	DET
dti-1378	376	39	goloco	goloco	ADJ
dti-1378	376	40	binding	bind	VERB
dti-1378	376	41	sites	site	NOUN
dti-1378	376	42	through	through	ADP
dti-1378	376	43	their	their	PRON
dti-1378	376	44	common	common	ADJ
dti-1378	376	45	shared	share	VERB
dti-1378	376	46	conserved	conserve	VERB
dti-1378	376	47	residues	residue	NOUN
dti-1378	376	48	.	.	PUNCT
dti-1378	377	1	the	the	DET
dti-1378	377	2	switch	switch	NOUN
dti-1378	377	3	ii	ii	PROPN
dti-1378	377	4	influences	influence	VERB
dti-1378	377	5	the	the	DET
dti-1378	377	6	tight	tight	ADJ
dti-1378	377	7	coupling	coupling	NOUN
dti-1378	377	8	of	of	ADP
dti-1378	377	9	the	the	DET
dti-1378	377	10	gtp	gtp	PROPN
dti-1378	377	11	/	/	SYM
dti-1378	377	12	mg2	mg2	PROPN
dti-1378	377	13	+	+	NOUN
dti-1378	377	14	ion	ion	NOUN
dti-1378	377	15	complex	complex	NOUN
dti-1378	377	16	through	through	ADP
dti-1378	377	17	the	the	DET
dti-1378	377	18	shared	share	VERB
dti-1378	377	19	gly210	gly210	NOUN
dti-1378	377	20	with	with	ADP
dti-1378	377	21	dxxd	dxxd	PROPN
dti-1378	377	22	near	near	ADP
dti-1378	377	23	the	the	DET
dti-1378	377	24	n	n	CCONJ
dti-1378	377	25	-	-	PUNCT
dti-1378	377	26	terminal	terminal	ADJ
dti-1378	377	27	end	end	NOUN
dti-1378	377	28	of	of	ADP
dti-1378	377	29	the	the	DET
dti-1378	377	30	switch	switch	NOUN
dti-1378	377	31	ii	ii	PROPN
dti-1378	377	32	helix.66	helix.66	PROPN
dti-1378	377	33	in	in	ADP
dti-1378	377	34	this	this	DET
dti-1378	377	35	superfamily	superfamily	NOUN
dti-1378	377	36	,	,	PUNCT
dti-1378	377	37	the	the	DET
dti-1378	377	38	binding	bind	VERB
dti-1378	377	39	energy	energy	NOUN
dti-1378	377	40	of	of	ADP
dti-1378	377	41	gtp	gtp	NOUN
dti-1378	377	42	is	be	AUX
dti-1378	377	43	normally	normally	ADV
dti-1378	377	44	used	use	VERB
dti-1378	377	45	to	to	PART
dti-1378	377	46	stabilize	stabilize	VERB
dti-1378	377	47	switch	switch	NOUN
dti-1378	377	48	regions	region	NOUN
dti-1378	377	49	,	,	PUNCT
dti-1378	377	50	so	so	SCONJ
dti-1378	377	51	that	that	SCONJ
dti-1378	377	52	a	a	DET
dti-1378	377	53	conformation	conformation	NOUN
dti-1378	377	54	is	be	AUX
dti-1378	377	55	produced	produce	VERB
dti-1378	377	56	that	that	PRON
dti-1378	377	57	favors	favor	VERB
dti-1378	377	58	its	its	PRON
dti-1378	377	59	association	association	NOUN
dti-1378	377	60	http://www.la-press.com	http://www.la-press.com	X
dti-1378	377	61	mbah	mbah	PROPN
dti-1378	377	62	et	et	PROPN
dti-1378	377	63	al	al	PROPN
dti-1378	377	64	56	56	NUM
dti-1378	377	65	drug	drug	NOUN
dti-1378	377	66	target	target	NOUN
dti-1378	377	67	insights	insight	NOUN
dti-1378	377	68	2012:6	2012:6	NUM
dti-1378	377	69	with	with	ADP
dti-1378	377	70	an	an	DET
dti-1378	377	71	effector	effector	NOUN
dti-1378	377	72	.	.	PUNCT
dti-1378	378	1	the	the	DET
dti-1378	378	2	switch	switch	PROPN
dti-1378	378	3	ii	ii	PROPN
dti-1378	378	4	region	region	NOUN
dti-1378	378	5	is	be	AUX
dti-1378	378	6	relatively	relatively	ADV
dti-1378	378	7	mobile	mobile	ADJ
dti-1378	378	8	at	at	ADP
dti-1378	378	9	the	the	DET
dti-1378	378	10	effector	effector	NOUN
dti-1378	378	11	binding	bind	VERB
dti-1378	378	12	region	region	NOUN
dti-1378	378	13	,	,	PUNCT
dti-1378	378	14	particularly	particularly	ADV
dti-1378	378	15	in	in	ADP
dti-1378	378	16	the	the	DET
dti-1378	378	17	gtp	gtp	NOUN
dti-1378	378	18	bound	bind	VERB
dti-1378	378	19	form	form	NOUN
dti-1378	378	20	.	.	PUNCT
dti-1378	379	1	gly220	gly220	NOUN
dti-1378	379	2	in	in	ADP
dti-1378	379	3	switch	switch	NOUN
dti-1378	379	4	ii	ii	PROPN
dti-1378	379	5	and	and	CCONJ
dti-1378	379	6	dxxd	dxxd	PROPN
dti-1378	379	7	(	(	PUNCT
dti-1378	379	8	table	table	NOUN
dti-1378	379	9	5	5	NUM
dti-1378	379	10	)	)	PUNCT
dti-1378	379	11	might	might	AUX
dti-1378	379	12	be	be	AUX
dti-1378	379	13	the	the	DET
dti-1378	379	14	determining	determining	NOUN
dti-1378	379	15	point	point	NOUN
dti-1378	379	16	for	for	ADP
dti-1378	379	17	the	the	DET
dti-1378	379	18	reorientation	reorientation	NOUN
dti-1378	379	19	and	and	CCONJ
dti-1378	379	20	partial	partial	ADJ
dti-1378	379	21	refolding	refolding	NOUN
dti-1378	379	22	of	of	ADP
dti-1378	379	23	the	the	DET
dti-1378	379	24	helical	helical	ADJ
dti-1378	379	25	region	region	NOUN
dti-1378	379	26	of	of	ADP
dti-1378	379	27	switch	switch	NOUN
dti-1378	379	28	ii61	ii61	PROPN
dti-1378	379	29	due	due	ADP
dti-1378	379	30	to	to	ADP
dti-1378	379	31	its	its	PRON
dti-1378	379	32	contribution	contribution	NOUN
dti-1378	379	33	to	to	ADP
dti-1378	379	34	forming	form	VERB
dti-1378	379	35	a	a	DET
dti-1378	379	36	hydrogen	hydrogen	NOUN
dti-1378	379	37	bond	bond	NOUN
dti-1378	379	38	with	with	ADP
dti-1378	379	39	the	the	DET
dti-1378	379	40	gamma	gamma	NOUN
dti-1378	379	41	-	-	PUNCT
dti-1378	379	42	phosphate	phosphate	NOUN
dti-1378	379	43	,	,	PUNCT
dti-1378	379	44	as	as	SCONJ
dti-1378	379	45	mentioned	mention	VERB
dti-1378	379	46	above.61	above.61	NOUN
dti-1378	379	47	however	however	ADV
dti-1378	379	48	,	,	PUNCT
dti-1378	379	49	there	there	PRON
dti-1378	379	50	is	be	VERB
dti-1378	379	51	a	a	DET
dti-1378	379	52	slight	slight	ADJ
dti-1378	379	53	difference	difference	NOUN
dti-1378	379	54	in	in	ADP
dti-1378	379	55	structural	structural	ADJ
dti-1378	379	56	position	position	NOUN
dti-1378	379	57	between	between	ADP
dti-1378	379	58	switch	switch	NOUN
dti-1378	379	59	i	i	PRON
dti-1378	379	60	and	and	CCONJ
dti-1378	379	61	switch	switch	VERB
dti-1378	379	62	ii	ii	NOUN
dti-1378	379	63	regions	region	NOUN
dti-1378	379	64	(	(	PUNCT
dti-1378	379	65	fig	fig	NOUN
dti-1378	379	66	.	.	PUNCT
dti-1378	380	1	10	10	NUM
dti-1378	380	2	a	a	PRON
dti-1378	380	3	)	)	PUNCT
dti-1378	380	4	.	.	PUNCT
dti-1378	381	1	both	both	PRON
dti-1378	381	2	are	be	AUX
dti-1378	381	3	located	locate	VERB
dti-1378	381	4	on	on	ADP
dti-1378	381	5	the	the	DET
dti-1378	381	6	protein	protein	NOUN
dti-1378	381	7	surface	surface	NOUN
dti-1378	381	8	,	,	PUNCT
dti-1378	381	9	but	but	CCONJ
dti-1378	381	10	the	the	DET
dti-1378	381	11	switch	switch	NOUN
dti-1378	381	12	ii	ii	PROPN
dti-1378	381	13	(	(	PUNCT
dti-1378	381	14	yellow	yellow	ADJ
dti-1378	381	15	)	)	PUNCT
dti-1378	381	16	residues	residue	NOUN
dti-1378	381	17	are	be	AUX
dti-1378	381	18	oriented	orient	VERB
dti-1378	381	19	outwards	outward	NOUN
dti-1378	381	20	,	,	PUNCT
dti-1378	381	21	while	while	SCONJ
dti-1378	381	22	the	the	DET
dti-1378	381	23	switch	switch	NOUN
dti-1378	381	24	i	i	PRON
dti-1378	381	25	(	(	PUNCT
dti-1378	381	26	green	green	ADJ
dti-1378	381	27	)	)	PUNCT
dti-1378	381	28	residues	residue	NOUN
dti-1378	381	29	form	form	VERB
dti-1378	381	30	part	part	NOUN
dti-1378	381	31	of	of	ADP
dti-1378	381	32	the	the	DET
dti-1378	381	33	active	active	ADJ
dti-1378	381	34	site	site	NOUN
dti-1378	381	35	(	(	PUNCT
dti-1378	381	36	fold	fold	ADJ
dti-1378	381	37	)	)	PUNCT
dti-1378	381	38	of	of	ADP
dti-1378	381	39	the	the	DET
dti-1378	381	40	protein	protein	NOUN
dti-1378	381	41	,	,	PUNCT
dti-1378	381	42	and	and	CCONJ
dti-1378	381	43	are	be	AUX
dti-1378	381	44	localized	localize	VERB
dti-1378	381	45	at	at	ADP
dti-1378	381	46	the	the	DET
dti-1378	381	47	gateway	gateway	NOUN
dti-1378	381	48	of	of	ADP
dti-1378	381	49	the	the	DET
dti-1378	381	50	active	active	ADJ
dti-1378	381	51	site	site	NOUN
dti-1378	381	52	of	of	ADP
dti-1378	381	53	the	the	DET
dti-1378	381	54	protein	protein	NOUN
dti-1378	381	55	.	.	PUNCT
dti-1378	382	1	the	the	DET
dti-1378	382	2	thr188	thr188	PROPN
dti-1378	382	3	shared	share	VERB
dti-1378	382	4	between	between	ADP
dti-1378	382	5	the	the	DET
dti-1378	382	6	gtp	gtp	PROPN
dti-1378	382	7	/	/	SYM
dti-1378	382	8	mg2	mg2	PROPN
dti-1378	382	9	+	+	NOUN
dti-1378	382	10	ion	ion	NOUN
dti-1378	382	11	complex	complex	NOUN
dti-1378	382	12	and	and	CCONJ
dti-1378	382	13	switch	switch	NOUN
dti-1378	382	14	i	i	PRON
dti-1378	382	15	region	region	NOUN
dti-1378	382	16	may	may	AUX
dti-1378	382	17	account	account	VERB
dti-1378	382	18	for	for	ADP
dti-1378	382	19	differences	difference	NOUN
dti-1378	382	20	in	in	ADP
dti-1378	382	21	the	the	DET
dti-1378	382	22	active	active	ADJ
dti-1378	382	23	site	site	NOUN
dti-1378	382	24	location	location	NOUN
dti-1378	382	25	.	.	PUNCT
dti-1378	383	1	the	the	DET
dti-1378	383	2	gtp	gtp	PROPN
dti-1378	383	3	/	/	SYM
dti-1378	383	4	mg2	mg2	PROPN
dti-1378	383	5	+	+	NOUN
dti-1378	383	6	ion	ion	NOUN
dti-1378	383	7	binding	bind	VERB
dti-1378	383	8	site	site	NOUN
dti-1378	383	9	residues	residue	NOUN
dti-1378	383	10	are	be	AUX
dti-1378	383	11	located	locate	VERB
dti-1378	383	12	in	in	ADP
dti-1378	383	13	the	the	DET
dti-1378	383	14	active	active	ADJ
dti-1378	383	15	cavity	cavity	NOUN
dti-1378	383	16	of	of	ADP
dti-1378	383	17	the	the	DET
dti-1378	383	18	protein	protein	NOUN
dti-1378	383	19	(	(	PUNCT
dti-1378	383	20	fig	fig	NOUN
dti-1378	383	21	.	.	PUNCT
dti-1378	384	1	8b	8b	NUM
dti-1378	384	2	)	)	PUNCT
dti-1378	384	3	.	.	PUNCT
dti-1378	385	1	g1	g1	PROPN
dti-1378	385	2	-	-	PUNCT
dti-1378	385	3	g5	g5	NOUN
dti-1378	385	4	box	box	NOUN
dti-1378	385	5	motif	motif	NOUN
dti-1378	385	6	interaction	interaction	NOUN
dti-1378	385	7	sites	site	NOUN
dti-1378	385	8	the	the	DET
dti-1378	385	9	g1	g1	PROPN
dti-1378	385	10	box	box	NOUN
dti-1378	385	11	motif	motif	NOUN
dti-1378	385	12	is	be	AUX
dti-1378	385	13	used	use	VERB
dti-1378	385	14	to	to	PART
dti-1378	385	15	define	define	VERB
dti-1378	385	16	gtp	gtp	NOUN
dti-1378	385	17	binding	bind	VERB
dti-1378	385	18	proteins	protein	NOUN
dti-1378	385	19	in	in	ADP
dti-1378	385	20	general.33	general.33	NOUN
dti-1378	385	21	only	only	ADV
dti-1378	385	22	the	the	DET
dti-1378	385	23	g2	g2	PROPN
dti-1378	385	24	box	box	PROPN
dti-1378	385	25	residue	residue	NOUN
dti-1378	385	26	thr188	thr188	NOUN
dti-1378	385	27	is	be	AUX
dti-1378	385	28	conserved	conserve	VERB
dti-1378	385	29	throughout	throughout	ADP
dti-1378	385	30	the	the	DET
dti-1378	385	31	superfamily	superfamily	NOUN
dti-1378	385	32	,	,	PUNCT
dti-1378	385	33	but	but	CCONJ
dti-1378	385	34	surrounding	surround	VERB
dti-1378	385	35	residues	residue	NOUN
dti-1378	385	36	are	be	AUX
dti-1378	385	37	conserved	conserve	VERB
dti-1378	385	38	within	within	ADP
dti-1378	385	39	the	the	DET
dti-1378	385	40	families	family	NOUN
dti-1378	385	41	.	.	PUNCT
dti-1378	386	1	as	as	SCONJ
dti-1378	386	2	mentioned	mention	VERB
dti-1378	386	3	above	above	ADV
dti-1378	386	4	,	,	PUNCT
dti-1378	386	5	its	its	PRON
dti-1378	386	6	main	main	ADJ
dti-1378	386	7	function	function	NOUN
dti-1378	386	8	is	be	AUX
dti-1378	386	9	to	to	PART
dti-1378	386	10	coordinate	coordinate	VERB
dti-1378	386	11	the	the	DET
dti-1378	386	12	magnesium	magnesium	NOUN
dti-1378	386	13	ions	ion	NOUN
dti-1378	386	14	of	of	ADP
dti-1378	386	15	the	the	DET
dti-1378	386	16	mg	mg	PROPN
dti-1378	386	17	-	-	PUNCT
dti-1378	386	18	gtp	gtp	NOUN
dti-1378	386	19	complex	complex	NOUN
dti-1378	386	20	,	,	PUNCT
dti-1378	386	21	which	which	PRON
dti-1378	386	22	can	can	AUX
dti-1378	386	23	thus	thus	ADV
dti-1378	386	24	sense	sense	VERB
dti-1378	386	25	the	the	DET
dti-1378	386	26	present	present	NOUN
dti-1378	386	27	of	of	ADP
dti-1378	386	28	the	the	DET
dti-1378	386	29	γ	γ	NOUN
dti-1378	386	30	-	-	NOUN
dti-1378	386	31	phosphate	phosphate	NOUN
dti-1378	386	32	.	.	PUNCT
dti-1378	387	1	the	the	DET
dti-1378	387	2	function	function	NOUN
dti-1378	387	3	of	of	ADP
dti-1378	387	4	the	the	DET
dti-1378	387	5	thr188	thr188	NOUN
dti-1378	387	6	had	have	AUX
dti-1378	387	7	been	be	AUX
dti-1378	387	8	elaborated	elaborate	VERB
dti-1378	387	9	extensively	extensively	ADV
dti-1378	387	10	in	in	ADP
dti-1378	387	11	both	both	CCONJ
dti-1378	387	12	the	the	DET
dti-1378	387	13	gtp	gtp	PROPN
dti-1378	387	14	/	/	SYM
dti-1378	387	15	mg2	mg2	PROPN
dti-1378	387	16	+	+	NOUN
dti-1378	387	17	ion	ion	NOUN
dti-1378	387	18	complex	complex	NOUN
dti-1378	387	19	and	and	CCONJ
dti-1378	387	20	the	the	DET
dti-1378	387	21	switch	switch	NOUN
dti-1378	387	22	i	i	PRON
dti-1378	387	23	sections	section	NOUN
dti-1378	387	24	above	above	ADV
dti-1378	387	25	.	.	PUNCT
dti-1378	388	1	the	the	DET
dti-1378	388	2	conserved	conserve	VERB
dti-1378	388	3	asp207	asp207	NOUN
dti-1378	388	4	residue	residue	NOUN
dti-1378	388	5	in	in	ADP
dti-1378	388	6	the	the	DET
dti-1378	388	7	g3	g3	PROPN
dti-1378	388	8	box	box	PROPN
dti-1378	388	9	motif	motif	NOUN
dti-1378	388	10	coordinates	coordinate	VERB
dti-1378	388	11	the	the	DET
dti-1378	388	12	mg2	mg2	PROPN
dti-1378	388	13	+	+	NOUN
dti-1378	388	14	ion	ion	NOUN
dti-1378	388	15	through	through	ADP
dti-1378	388	16	a	a	DET
dti-1378	388	17	water	water	NOUN
dti-1378	388	18	molecule	molecule	NOUN
dti-1378	388	19	,	,	PUNCT
dti-1378	388	20	and	and	CCONJ
dti-1378	388	21	the	the	DET
dti-1378	388	22	conserved	conserved	ADJ
dti-1378	388	23	gly220	gly220	NOUN
dti-1378	388	24	in	in	ADP
dti-1378	388	25	the	the	DET
dti-1378	388	26	switch	switch	NOUN
dti-1378	388	27	ii	ii	NOUN
dti-1378	388	28	and	and	CCONJ
dti-1378	388	29	in	in	ADP
dti-1378	388	30	the	the	DET
dti-1378	388	31	g3	g3	PROPN
dti-1378	388	32	box	box	NOUN
dti-1378	388	33	motif	motif	NOUN
dti-1378	388	34	determines	determine	VERB
dti-1378	388	35	the	the	DET
dti-1378	388	36	reorientation	reorientation	NOUN
dti-1378	388	37	and	and	CCONJ
dti-1378	388	38	partial	partial	ADJ
dti-1378	388	39	refolding	refolding	NOUN
dti-1378	388	40	of	of	ADP
dti-1378	388	41	the	the	DET
dti-1378	388	42	helical	helical	ADJ
dti-1378	388	43	region	region	NOUN
dti-1378	388	44	of	of	ADP
dti-1378	388	45	switch	switch	NOUN
dti-1378	388	46	ii61	ii61	PROPN
dti-1378	388	47	by	by	ADP
dti-1378	388	48	forming	form	VERB
dti-1378	388	49	a	a	DET
dti-1378	388	50	hydrogen	hydrogen	NOUN
dti-1378	388	51	bond	bond	NOUN
dti-1378	388	52	with	with	ADP
dti-1378	388	53	the	the	DET
dti-1378	388	54	γ	γ	NOUN
dti-1378	388	55	-	-	PUNCT
dti-1378	388	56	phosphate.61	phosphate.61	NOUN
dti-1378	388	57	the	the	DET
dti-1378	388	58	g3	g3	PROPN
dti-1378	388	59	box	box	NOUN
dti-1378	388	60	motif	motif	NOUN
dti-1378	388	61	is	be	AUX
dti-1378	388	62	also	also	ADV
dti-1378	388	63	known	know	VERB
dti-1378	388	64	to	to	PART
dti-1378	388	65	form	form	VERB
dti-1378	388	66	an	an	DET
dti-1378	388	67	integral	integral	ADJ
dti-1378	388	68	part	part	NOUN
dti-1378	388	69	of	of	ADP
dti-1378	388	70	the	the	DET
dti-1378	388	71	switch	switch	NOUN
dti-1378	388	72	2	2	NUM
dti-1378	388	73	region	region	NOUN
dti-1378	388	74	.	.	PUNCT
dti-1378	389	1	all	all	DET
dti-1378	389	2	five	five	NUM
dti-1378	389	3	loops	loop	NOUN
dti-1378	389	4	(	(	PUNCT
dti-1378	389	5	g1	g1	NOUN
dti-1378	389	6	-	-	PUNCT
dti-1378	389	7	g5	g5	NOUN
dti-1378	389	8	)	)	PUNCT
dti-1378	389	9	are	be	AUX
dti-1378	389	10	located	locate	VERB
dti-1378	389	11	in	in	ADP
dti-1378	389	12	the	the	DET
dti-1378	389	13	active	active	ADJ
dti-1378	389	14	fold	fold	NOUN
dti-1378	389	15	,	,	PUNCT
dti-1378	389	16	with	with	SCONJ
dti-1378	389	17	the	the	DET
dti-1378	389	18	g4	g4	NOUN
dti-1378	389	19	box	box	NOUN
dti-1378	389	20	motif	motif	NOUN
dti-1378	389	21	situated	situate	VERB
dti-1378	389	22	very	very	ADV
dti-1378	389	23	close	close	ADJ
dti-1378	389	24	to	to	ADP
dti-1378	389	25	g5	g5	VERB
dti-1378	389	26	box	box	NOUN
dti-1378	389	27	motif	motif	NOUN
dti-1378	389	28	.	.	PUNCT
dti-1378	390	1	the	the	DET
dti-1378	390	2	plausible	plausible	ADJ
dti-1378	390	3	reason	reason	NOUN
dti-1378	390	4	for	for	ADP
dti-1378	390	5	this	this	PRON
dti-1378	390	6	may	may	AUX
dti-1378	390	7	be	be	AUX
dti-1378	390	8	that	that	SCONJ
dti-1378	390	9	the	the	DET
dti-1378	390	10	g5	g5	PROPN
dti-1378	390	11	box	box	NOUN
dti-1378	390	12	motif	motif	NOUN
dti-1378	390	13	buttresses	buttress	VERB
dti-1378	390	14	the	the	DET
dti-1378	390	15	guanine	guanine	NOUN
dti-1378	390	16	base	base	PROPN
dti-1378	390	17	recognition	recognition	NOUN
dti-1378	390	18	site	site	NOUN
dti-1378	390	19	.	.	PUNCT
dti-1378	391	1	the	the	DET
dti-1378	391	2	residue	residue	NOUN
dti-1378	391	3	ala351	ala351	NOUN
dti-1378	391	4	may	may	AUX
dti-1378	391	5	be	be	AUX
dti-1378	391	6	the	the	DET
dti-1378	391	7	booster	booster	NOUN
dti-1378	391	8	component	component	NOUN
dti-1378	391	9	in	in	ADP
dti-1378	391	10	guanine	guanine	NOUN
dti-1378	391	11	site	site	NOUN
dti-1378	391	12	recognition	recognition	PROPN
dti-1378	391	13	.	.	PUNCT
dti-1378	392	1	the	the	DET
dti-1378	392	2	location	location	NOUN
dti-1378	392	3	of	of	ADP
dti-1378	392	4	the	the	DET
dti-1378	392	5	five	five	NUM
dti-1378	392	6	loops	loop	NOUN
dti-1378	392	7	in	in	ADP
dti-1378	392	8	the	the	DET
dti-1378	392	9	cavity	cavity	NOUN
dti-1378	392	10	indicates	indicate	VERB
dti-1378	392	11	their	their	PRON
dti-1378	392	12	importance	importance	NOUN
dti-1378	392	13	in	in	ADP
dti-1378	392	14	the	the	DET
dti-1378	392	15	binding	binding	NOUN
dti-1378	392	16	of	of	ADP
dti-1378	392	17	gtp	gtp	NOUN
dti-1378	392	18	molecules	molecule	NOUN
dti-1378	392	19	(	(	PUNCT
dti-1378	392	20	fig	fig	NOUN
dti-1378	392	21	.	.	PUNCT
dti-1378	392	22	11b	11b	NOUN
dti-1378	392	23	)	)	PUNCT
dti-1378	392	24	.	.	PUNCT
dti-1378	393	1	conclusion	conclusion	NOUN
dti-1378	393	2	we	we	PRON
dti-1378	393	3	have	have	AUX
dti-1378	393	4	elucidated	elucidate	VERB
dti-1378	393	5	the	the	DET
dti-1378	393	6	distinctive	distinctive	ADJ
dti-1378	393	7	characteristic	characteristic	ADJ
dti-1378	393	8	features	feature	NOUN
dti-1378	393	9	of	of	ADP
dti-1378	393	10	the	the	DET
dti-1378	393	11	s.	s.	PROPN
dti-1378	393	12	mansoni	mansoni	PROPN
dti-1378	393	13	smp_059340.1	smp_059340.1	PROPN
dti-1378	393	14	protein	protein	NOUN
dti-1378	393	15	,	,	PUNCT
dti-1378	393	16	a	a	DET
dti-1378	393	17	predicted	predict	VERB
dti-1378	393	18	drug	drug	NOUN
dti-1378	393	19	target	target	NOUN
dti-1378	393	20	,	,	PUNCT
dti-1378	393	21	from	from	ADP
dti-1378	393	22	its	its	PRON
dti-1378	393	23	primary	primary	ADJ
dti-1378	393	24	structure	structure	NOUN
dti-1378	393	25	to	to	PART
dti-1378	393	26	learn	learn	VERB
dti-1378	393	27	how	how	SCONJ
dti-1378	393	28	these	these	DET
dti-1378	393	29	features	feature	NOUN
dti-1378	393	30	contribute	contribute	VERB
dti-1378	393	31	to	to	ADP
dti-1378	393	32	the	the	DET
dti-1378	393	33	functioning	functioning	NOUN
dti-1378	393	34	and	and	CCONJ
dti-1378	393	35	regulation	regulation	NOUN
dti-1378	393	36	of	of	ADP
dti-1378	393	37	the	the	DET
dti-1378	393	38	developmental	developmental	ADJ
dti-1378	393	39	process	process	NOUN
dti-1378	393	40	in	in	ADP
dti-1378	393	41	the	the	DET
dti-1378	393	42	schistosome	schistosome	NOUN
dti-1378	393	43	’s	’s	PART
dti-1378	393	44	life	life	NOUN
dti-1378	393	45	cycle	cycle	NOUN
dti-1378	393	46	.	.	PUNCT
dti-1378	394	1	however	however	ADV
dti-1378	394	2	,	,	PUNCT
dti-1378	394	3	because	because	SCONJ
dti-1378	394	4	these	these	DET
dti-1378	394	5	distinctive	distinctive	ADJ
dti-1378	394	6	characteristic	characteristic	ADJ
dti-1378	394	7	features	feature	NOUN
dti-1378	394	8	are	be	AUX
dti-1378	394	9	predictions	prediction	NOUN
dti-1378	394	10	,	,	PUNCT
dti-1378	394	11	they	they	PRON
dti-1378	394	12	should	should	AUX
dti-1378	394	13	be	be	AUX
dti-1378	394	14	considered	consider	VERB
dti-1378	394	15	with	with	ADP
dti-1378	394	16	caution	caution	NOUN
dti-1378	394	17	.	.	PUNCT
dti-1378	395	1	the	the	DET
dti-1378	395	2	protein	protein	NOUN
dti-1378	395	3	is	be	AUX
dti-1378	395	4	basic	basic	ADJ
dti-1378	395	5	and	and	CCONJ
dti-1378	395	6	moderately	moderately	ADV
dti-1378	395	7	hydrophilic	hydrophilic	ADJ
dti-1378	395	8	,	,	PUNCT
dti-1378	395	9	carrying	carry	VERB
dti-1378	395	10	a	a	DET
dti-1378	395	11	net	net	ADJ
dti-1378	395	12	positive	positive	ADJ
dti-1378	395	13	charge	charge	NOUN
dti-1378	395	14	with	with	ADP
dti-1378	395	15	possible	possible	ADJ
dti-1378	395	16	antigenic	antigenic	ADJ
dti-1378	395	17	properties	property	NOUN
dti-1378	395	18	on	on	ADP
dti-1378	395	19	its	its	PRON
dti-1378	395	20	surface	surface	NOUN
dti-1378	395	21	.	.	PUNCT
dti-1378	396	1	smp_059340.1	smp_059340.1	PROPN
dti-1378	396	2	is	be	AUX
dti-1378	396	3	predicted	predict	VERB
dti-1378	396	4	to	to	PART
dti-1378	396	5	be	be	AUX
dti-1378	396	6	stable	stable	ADJ
dti-1378	396	7	within	within	ADP
dti-1378	396	8	a	a	DET
dti-1378	396	9	wide	wide	ADJ
dti-1378	396	10	range	range	NOUN
dti-1378	396	11	of	of	ADP
dti-1378	396	12	temperature	temperature	NOUN
dti-1378	396	13	,	,	PUNCT
dti-1378	396	14	with	with	ADP
dti-1378	396	15	a	a	DET
dti-1378	396	16	high	high	ADJ
dti-1378	396	17	possibility	possibility	NOUN
dti-1378	396	18	of	of	ADP
dti-1378	396	19	being	be	AUX
dti-1378	396	20	analyzed	analyze	VERB
dti-1378	396	21	using	use	VERB
dti-1378	396	22	a	a	DET
dti-1378	396	23	uv	uv	NOUN
dti-1378	396	24	spectrum	spectrum	NOUN
dti-1378	396	25	assay	assay	PROPN
dti-1378	396	26	protocol	protocol	NOUN
dti-1378	396	27	.	.	PUNCT
dti-1378	397	1	further	far	ADV
dti-1378	397	2	,	,	PUNCT
dti-1378	397	3	smp_059340.1	smp_059340.1	PROPN
dti-1378	397	4	is	be	AUX
dti-1378	397	5	a	a	DET
dti-1378	397	6	soluble	soluble	ADJ
dti-1378	397	7	protein	protein	NOUN
dti-1378	397	8	consisting	consist	VERB
dti-1378	397	9	of	of	ADP
dti-1378	397	10	mixed	mixed	ADJ
dti-1378	397	11	secondary	secondary	ADJ
dti-1378	397	12	structure	structure	NOUN
dti-1378	397	13	features	feature	NOUN
dti-1378	397	14	,	,	PUNCT
dti-1378	397	15	with	with	ADP
dti-1378	397	16	the	the	DET
dti-1378	397	17	transmembrane	transmembrane	NOUN
dti-1378	397	18	helices	helix	NOUN
dti-1378	397	19	having	have	VERB
dti-1378	397	20	an	an	DET
dti-1378	397	21	inside	inside	NOUN
dti-1378	397	22	→	→	PUNCT
dti-1378	397	23	outside	outside	ADJ
dti-1378	397	24	orientation	orientation	NOUN
dti-1378	397	25	.	.	PUNCT
dti-1378	398	1	the	the	DET
dti-1378	398	2	quality	quality	NOUN
dti-1378	398	3	of	of	ADP
dti-1378	398	4	the	the	DET
dti-1378	398	5	modeled	model	VERB
dti-1378	398	6	smp_059340.1	smp_059340.1	PROPN
dti-1378	398	7	structure	structure	NOUN
dti-1378	398	8	,	,	PUNCT
dti-1378	398	9	measured	measure	VERB
dti-1378	398	10	in	in	ADP
dti-1378	398	11	terms	term	NOUN
dti-1378	398	12	of	of	ADP
dti-1378	398	13	reliability	reliability	NOUN
dti-1378	398	14	using	use	VERB
dti-1378	398	15	the	the	DET
dti-1378	398	16	qmean	qmean	ADJ
dti-1378	398	17	score4	score4	PROPN
dti-1378	398	18	range	range	NOUN
dti-1378	398	19	,	,	PUNCT
dti-1378	398	20	was	be	AUX
dti-1378	398	21	0.68	0.68	NUM
dti-1378	398	22	.	.	PUNCT
dti-1378	399	1	the	the	DET
dti-1378	399	2	ramachandran	ramachandran	PROPN
dti-1378	399	3	plot	plot	NOUN
dti-1378	399	4	analysis	analysis	NOUN
dti-1378	399	5	indicates	indicate	VERB
dti-1378	399	6	that	that	SCONJ
dti-1378	399	7	95.72	95.72	NUM
dti-1378	399	8	%	%	NOUN
dti-1378	399	9	(	(	PUNCT
dti-1378	399	10	320	320	NUM
dti-1378	399	11	residues	residue	NOUN
dti-1378	399	12	)	)	PUNCT
dti-1378	399	13	of	of	ADP
dti-1378	399	14	the	the	DET
dti-1378	399	15	model	model	NOUN
dti-1378	399	16	residues	residue	NOUN
dti-1378	399	17	are	be	AUX
dti-1378	399	18	located	locate	VERB
dti-1378	399	19	in	in	ADP
dti-1378	399	20	the	the	DET
dti-1378	399	21	core	core	NOUN
dti-1378	399	22	or	or	CCONJ
dti-1378	399	23	are	be	AUX
dti-1378	399	24	favored	favor	VERB
dti-1378	399	25	.	.	PUNCT
dti-1378	400	1	as	as	ADP
dti-1378	400	2	such	such	ADJ
dti-1378	400	3	,	,	PUNCT
dti-1378	400	4	the	the	DET
dti-1378	400	5	predicted	predict	VERB
dti-1378	400	6	model	model	NOUN
dti-1378	400	7	can	can	AUX
dti-1378	400	8	be	be	AUX
dti-1378	400	9	assumed	assume	VERB
dti-1378	400	10	to	to	PART
dti-1378	400	11	be	be	AUX
dti-1378	400	12	of	of	ADP
dti-1378	400	13	good	good	ADJ
dti-1378	400	14	quality	quality	NOUN
dti-1378	400	15	and	and	CCONJ
dti-1378	400	16	biologically	biologically	ADV
dti-1378	400	17	informative	informative	ADJ
dti-1378	400	18	.	.	PUNCT
dti-1378	401	1	with	with	ADP
dti-1378	401	2	respect	respect	NOUN
dti-1378	401	3	to	to	ADP
dti-1378	401	4	the	the	DET
dti-1378	401	5	reliability	reliability	NOUN
dti-1378	401	6	of	of	ADP
dti-1378	401	7	the	the	DET
dti-1378	401	8	modeled	model	VERB
dti-1378	401	9	protein	protein	NOUN
dti-1378	401	10	structure	structure	NOUN
dti-1378	401	11	,	,	PUNCT
dti-1378	401	12	the	the	DET
dti-1378	401	13	key	key	ADJ
dti-1378	401	14	features	feature	NOUN
dti-1378	401	15	controlling	control	VERB
dti-1378	401	16	gtp	gtp	NOUN
dti-1378	401	17	binding	binding	ADJ
dti-1378	401	18	and	and	CCONJ
dti-1378	401	19	effective	effective	ADJ
dti-1378	401	20	pathway	pathway	NOUN
dti-1378	401	21	regulations	regulation	NOUN
dti-1378	401	22	were	be	AUX
dti-1378	401	23	found	find	VERB
dti-1378	401	24	to	to	PART
dti-1378	401	25	be	be	AUX
dti-1378	401	26	thr188	thr188	PROPN
dti-1378	401	27	,	,	PUNCT
dti-1378	401	28	gly210	gly210	NOUN
dti-1378	401	29	,	,	PUNCT
dti-1378	401	30	asp207	asp207	NOUN
dti-1378	401	31	and	and	CCONJ
dti-1378	401	32	ser53	ser53	PROPN
dti-1378	401	33	.	.	PUNCT
dti-1378	402	1	analysis	analysis	NOUN
dti-1378	402	2	of	of	ADP
dti-1378	402	3	the	the	DET
dti-1378	402	4	protein	protein	NOUN
dti-1378	402	5	domain	domain	NOUN
dti-1378	402	6	organization	organization	NOUN
dti-1378	402	7	revealed	reveal	VERB
dti-1378	402	8	that	that	SCONJ
dti-1378	402	9	the	the	DET
dti-1378	402	10	pathway	pathway	NOUN
dti-1378	402	11	regulated	regulate	VERB
dti-1378	402	12	by	by	ADP
dti-1378	402	13	this	this	DET
dti-1378	402	14	protein	protein	NOUN
dti-1378	402	15	is	be	AUX
dti-1378	402	16	very	very	ADV
dti-1378	402	17	complex	complex	ADJ
dti-1378	402	18	,	,	PUNCT
dti-1378	402	19	and	and	CCONJ
dti-1378	402	20	that	that	SCONJ
dti-1378	402	21	these	these	DET
dti-1378	402	22	domains	domain	NOUN
dti-1378	402	23	are	be	AUX
dti-1378	402	24	interconnected	interconnect	VERB
dti-1378	402	25	through	through	ADP
dti-1378	402	26	shared	share	VERB
dti-1378	402	27	conserved	conserve	VERB
dti-1378	402	28	residues	residue	NOUN
dti-1378	402	29	regulating	regulate	VERB
dti-1378	402	30	the	the	DET
dti-1378	402	31	network	network	NOUN
dti-1378	402	32	.	.	PUNCT
dti-1378	403	1	these	these	DET
dti-1378	403	2	findings	finding	NOUN
dti-1378	403	3	offer	offer	VERB
dti-1378	403	4	new	new	ADJ
dti-1378	403	5	insights	insight	NOUN
dti-1378	403	6	into	into	ADP
dti-1378	403	7	the	the	DET
dti-1378	403	8	dynamic	dynamic	ADJ
dti-1378	403	9	and	and	CCONJ
dti-1378	403	10	functional	functional	ADJ
dti-1378	403	11	determinants	determinant	NOUN
dti-1378	403	12	of	of	ADP
dti-1378	403	13	the	the	DET
dti-1378	403	14	smp_059340.1	smp_059340.1	PROPN
dti-1378	403	15	protein	protein	NOUN
dti-1378	403	16	in	in	ADP
dti-1378	403	17	regulation	regulation	NOUN
dti-1378	403	18	of	of	ADP
dti-1378	403	19	the	the	DET
dti-1378	403	20	life	life	NOUN
dti-1378	403	21	cycle	cycle	NOUN
dti-1378	403	22	pathway	pathway	NOUN
dti-1378	403	23	.	.	PUNCT
dti-1378	404	1	these	these	DET
dti-1378	404	2	conspicuous	conspicuous	ADJ
dti-1378	404	3	structural	structural	ADJ
dti-1378	404	4	and	and	CCONJ
dti-1378	404	5	functional	functional	ADJ
dti-1378	404	6	biomarkers	biomarker	NOUN
dti-1378	404	7	in	in	ADP
dti-1378	404	8	the	the	DET
dti-1378	404	9	smp_058340.1	smp_058340.1	PROPN
dti-1378	404	10	encoded	encode	VERB
dti-1378	404	11	protein	protein	NOUN
dti-1378	404	12	will	will	AUX
dti-1378	404	13	add	add	VERB
dti-1378	404	14	impetus	impetus	NOUN
dti-1378	404	15	in	in	ADP
dti-1378	404	16	biological	biological	ADJ
dti-1378	404	17	experimental	experimental	ADJ
dti-1378	404	18	design	design	NOUN
dti-1378	404	19	,	,	PUNCT
dti-1378	404	20	particularly	particularly	ADV
dti-1378	404	21	site	site	NOUN
dti-1378	404	22	–	–	PUNCT
dti-1378	404	23	directed	direct	VERB
dti-1378	404	24	mutagenesis	mutagenesis	NOUN
dti-1378	404	25	experiments	experiment	NOUN
dti-1378	404	26	regulating	regulate	VERB
dti-1378	404	27	the	the	DET
dti-1378	404	28	pathway	pathway	NOUN
dti-1378	404	29	control	control	NOUN
dti-1378	404	30	by	by	ADP
dti-1378	404	31	this	this	DET
dti-1378	404	32	gene	gene	NOUN
dti-1378	404	33	during	during	ADP
dti-1378	404	34	the	the	DET
dti-1378	404	35	developmental	developmental	ADJ
dti-1378	404	36	stages	stage	NOUN
dti-1378	404	37	of	of	ADP
dti-1378	404	38	the	the	DET
dti-1378	404	39	s.	s.	PROPN
dti-1378	404	40	mansoni	mansoni	PROPN
dti-1378	404	41	.	.	PUNCT
dti-1378	405	1	we	we	PRON
dti-1378	405	2	envision	envision	VERB
dti-1378	405	3	that	that	SCONJ
dti-1378	405	4	by	by	ADP
dti-1378	405	5	following	follow	VERB
dti-1378	405	6	this	this	DET
dti-1378	405	7	type	type	NOUN
dti-1378	405	8	of	of	ADP
dti-1378	405	9	approach	approach	NOUN
dti-1378	405	10	,	,	PUNCT
dti-1378	405	11	the	the	DET
dti-1378	405	12	distinctive	distinctive	ADJ
dti-1378	405	13	functional	functional	ADJ
dti-1378	405	14	features	feature	NOUN
dti-1378	405	15	and	and	CCONJ
dti-1378	405	16	the	the	DET
dti-1378	405	17	derived	derive	VERB
dti-1378	405	18	3d	3d	NUM
dti-1378	405	19	model	model	NOUN
dti-1378	405	20	can	can	AUX
dti-1378	405	21	provide	provide	VERB
dti-1378	405	22	a	a	DET
dti-1378	405	23	simplistic	simplistic	ADJ
dti-1378	405	24	understanding	understanding	NOUN
dti-1378	405	25	of	of	ADP
dti-1378	405	26	important	important	ADJ
dti-1378	405	27	biological	biological	ADJ
dti-1378	405	28	issues	issue	NOUN
dti-1378	405	29	,	,	PUNCT
dti-1378	405	30	such	such	ADJ
dti-1378	405	31	as	as	ADP
dti-1378	405	32	how	how	SCONJ
dti-1378	405	33	protein	protein	NOUN
dti-1378	405	34	domains	domain	NOUN
dti-1378	405	35	interact	interact	VERB
dti-1378	405	36	at	at	ADP
dti-1378	405	37	a	a	DET
dti-1378	405	38	molecular	molecular	ADJ
dti-1378	405	39	level	level	NOUN
dti-1378	405	40	in	in	ADP
dti-1378	405	41	a	a	DET
dti-1378	405	42	network	network	NOUN
dti-1378	405	43	.	.	PUNCT
dti-1378	406	1	http://www.la-press.com	http://www.la-press.com	X
dti-1378	406	2	drug	drug	NOUN
dti-1378	406	3	target	target	NOUN
dti-1378	406	4	features	feature	NOUN
dti-1378	406	5	of	of	ADP
dti-1378	406	6	schistosoma	schistosoma	ADJ
dti-1378	406	7	adenylyl	adenylyl	NOUN
dti-1378	406	8	cyclase	cyclase	NOUN
dti-1378	406	9	activity	activity	NOUN
dti-1378	406	10	drug	drug	NOUN
dti-1378	406	11	target	target	NOUN
dti-1378	406	12	insights	insight	NOUN
dti-1378	406	13	2012:6	2012:6	NUM
dti-1378	406	14	57	57	NUM
dti-1378	406	15	the	the	DET
dti-1378	406	16	modeled	model	VERB
dti-1378	406	17	binding	bind	VERB
dti-1378	406	18	interfaces	interface	NOUN
dti-1378	406	19	and	and	CCONJ
dti-1378	406	20	their	their	PRON
dti-1378	406	21	residues	residue	NOUN
dti-1378	406	22	could	could	AUX
dti-1378	406	23	be	be	AUX
dti-1378	406	24	used	use	VERB
dti-1378	406	25	as	as	ADP
dti-1378	406	26	starting	start	VERB
dti-1378	406	27	points	point	NOUN
dti-1378	406	28	to	to	PART
dti-1378	406	29	guide	guide	VERB
dti-1378	406	30	selective	selective	ADJ
dti-1378	406	31	modulations	modulation	NOUN
dti-1378	406	32	of	of	ADP
dti-1378	406	33	interactions	interaction	NOUN
dti-1378	406	34	within	within	ADP
dti-1378	406	35	the	the	DET
dti-1378	406	36	pathway	pathway	NOUN
dti-1378	406	37	using	use	VERB
dti-1378	406	38	small	small	ADJ
dti-1378	406	39	molecules	molecule	NOUN
dti-1378	406	40	,	,	PUNCT
dti-1378	406	41	peptides	peptide	NOUN
dti-1378	406	42	,	,	PUNCT
dti-1378	406	43	or	or	CCONJ
dti-1378	406	44	mutagenesis	mutagenesis	NOUN
dti-1378	406	45	.	.	PUNCT
dti-1378	407	1	funding	fund	VERB
dti-1378	407	2	national	national	PROPN
dti-1378	407	3	institutes	institutes	PROPN
dti-1378	407	4	of	of	ADP
dti-1378	407	5	health	health	NOUN
dti-1378	407	6	:	:	PUNCT
dti-1378	407	7	research	research	NOUN
dti-1378	407	8	centers	center	NOUN
dti-1378	407	9	in	in	ADP
dti-1378	407	10	minority	minority	NOUN
dti-1378	407	11	institutions	institution	NOUN
dti-1378	407	12	(	(	PUNCT
dti-1378	407	13	rcmi)—center	rcmi)—center	ADP
dti-1378	407	14	for	for	ADP
dti-1378	407	15	environmental	environmental	ADJ
dti-1378	407	16	health	health	NOUN
dti-1378	407	17	at	at	ADP
dti-1378	407	18	jackson	jackson	PROPN
dti-1378	407	19	state	state	PROPN
dti-1378	407	20	university	university	PROPN
dti-1378	407	21	(	(	PUNCT
dti-1378	407	22	nihncrr	nihncrr	NOUN
dti-1378	407	23	2g12rr013459	2g12rr013459	NOUN
dti-1378	407	24	)	)	PUNCT
dti-1378	407	25	;	;	PUNCT
dti-1378	407	26	mississippi	mississippi	PROPN
dti-1378	407	27	idea	idea	NOUN
dti-1378	407	28	network	network	NOUN
dti-1378	407	29	for	for	ADP
dti-1378	407	30	biomedical	biomedical	ADJ
dti-1378	407	31	research	research	NOUN
dti-1378	407	32	excellence	excellence	PROPN
dti-1378	407	33	(	(	PUNCT
dti-1378	407	34	nih	nih	NOUN
dti-1378	407	35	-	-	PUNCT
dti-1378	407	36	ncrrp20rr016476	ncrrp20rr016476	NOUN
dti-1378	407	37	and	and	CCONJ
dti-1378	407	38	nih	nih	PROPN
dti-1378	407	39	-	-	PUNCT
dti-1378	407	40	nigms8p20gm103476	nigms8p20gm103476	NOUN
dti-1378	407	41	)	)	PUNCT
dti-1378	407	42	;	;	PUNCT
dti-1378	407	43	bioinformatics	bioinformatics	NOUN
dti-1378	407	44	programs	program	NOUN
dti-1378	407	45	in	in	ADP
dti-1378	407	46	minority	minority	NOUN
dti-1378	407	47	institutions	institution	NOUN
dti-1378	407	48	(	(	PUNCT
dti-1378	407	49	1t36gm095335	1t36gm095335	NUM
dti-1378	407	50	)	)	PUNCT
dti-1378	407	51	;	;	PUNCT
dti-1378	407	52	national	national	ADJ
dti-1378	407	53	center	center	NOUN
dti-1378	407	54	for	for	ADP
dti-1378	407	55	integrative	integrative	ADJ
dti-1378	407	56	biomedical	biomedical	ADJ
dti-1378	407	57	informatics	informatic	NOUN
dti-1378	407	58	(	(	PUNCT
dti-1378	407	59	u54da021519	u54da021519	ADJ
dti-1378	407	60	)	)	PUNCT
dti-1378	407	61	.	.	PUNCT
dti-1378	408	1	national	national	PROPN
dti-1378	408	2	science	science	PROPN
dti-1378	408	3	foundation	foundation	PROPN
dti-1378	408	4	:	:	PUNCT
dti-1378	408	5	mississippi	mississippi	PROPN
dti-1378	408	6	nsfepscor	nsfepscor	PROPN
dti-1378	408	7	grant	grant	PROPN
dti-1378	408	8	award	award	PROPN
dti-1378	408	9	(	(	PUNCT
dti-1378	408	10	eps-0903787	eps-0903787	NOUN
dti-1378	408	11	and	and	CCONJ
dti-1378	408	12	eps	eps	PROPN
dti-1378	408	13	1006883	1006883	NUM
dti-1378	408	14	)	)	PUNCT
dti-1378	408	15	;	;	PUNCT
dti-1378	408	16	undergraduate	undergraduate	NOUN
dti-1378	408	17	research	research	NOUN
dti-1378	408	18	and	and	CCONJ
dti-1378	408	19	mentoring	mentor	VERB
dti-1378	408	20	program	program	NOUN
dti-1378	408	21	(	(	PUNCT
dti-1378	408	22	dbi0958179	dbi0958179	PROPN
dti-1378	408	23	)	)	PUNCT
dti-1378	408	24	and	and	CCONJ
dti-1378	408	25	visual	visual	ADJ
dti-1378	408	26	analytics	analytic	NOUN
dti-1378	408	27	in	in	ADP
dti-1378	408	28	biology	biology	NOUN
dti-1378	408	29	curriculum	curriculum	NOUN
dti-1378	408	30	network	network	NOUN
dti-1378	408	31	(	(	PUNCT
dti-1378	408	32	dbi-1062057	dbi-1062057	NOUN
dti-1378	408	33	)	)	PUNCT
dti-1378	408	34	.	.	PUNCT
dti-1378	409	1	us	us	PROPN
dti-1378	409	2	department	department	PROPN
dti-1378	409	3	of	of	ADP
dti-1378	409	4	homeland	homeland	NOUN
dti-1378	409	5	security	security	NOUN
dti-1378	409	6	science	science	NOUN
dti-1378	409	7	and	and	CCONJ
dti-1378	409	8	technology	technology	NOUN
dti-1378	409	9	directorate	directorate	NOUN
dti-1378	409	10	(	(	PUNCT
dti-1378	409	11	2009	2009	NUM
dti-1378	409	12	-	-	PUNCT
dti-1378	409	13	st-062	st-062	PROPN
dti-1378	409	14	-	-	PUNCT
dti-1378	409	15	000014	000014	NUM
dti-1378	409	16	;	;	PUNCT
dti-1378	409	17	2011	2011	NUM
dti-1378	409	18	-	-	PUNCT
dti-1378	409	19	st-062	st-062	PROPN
dti-1378	409	20	-	-	PUNCT
dti-1378	409	21	000048	000048	NUM
dti-1378	409	22	)	)	PUNCT
dti-1378	409	23	.	.	PUNCT
dti-1378	410	1	competing	compete	VERB
dti-1378	410	2	interests	interest	NOUN
dti-1378	410	3	author(s	author(s	NOUN
dti-1378	410	4	)	)	PUNCT
dti-1378	410	5	disclose	disclose	VERB
dti-1378	410	6	no	no	DET
dti-1378	410	7	potential	potential	ADJ
dti-1378	410	8	conflicts	conflict	NOUN
dti-1378	410	9	of	of	ADP
dti-1378	410	10	interest	interest	NOUN
dti-1378	410	11	.	.	PUNCT
dti-1378	411	1	author	author	NOUN
dti-1378	411	2	contributions	contribution	NOUN
dti-1378	411	3	conceived	conceive	VERB
dti-1378	411	4	and	and	CCONJ
dti-1378	411	5	designed	design	VERB
dti-1378	411	6	the	the	DET
dti-1378	411	7	experiments	experiment	NOUN
dti-1378	411	8	:	:	PUNCT
dti-1378	411	9	anm	anm	PROPN
dti-1378	411	10	,	,	PUNCT
dti-1378	411	11	rdi	rdi	PROPN
dti-1378	411	12	analyzed	analyze	VERB
dti-1378	411	13	the	the	DET
dti-1378	411	14	data	datum	NOUN
dti-1378	411	15	:	:	PUNCT
dti-1378	411	16	anm	anm	PROPN
dti-1378	411	17	,	,	PUNCT
dti-1378	411	18	rdi	rdi	PROPN
dti-1378	411	19	.	.	PROPN
dti-1378	411	20	wrote	write	VERB
dti-1378	411	21	the	the	DET
dti-1378	411	22	first	first	ADJ
dti-1378	411	23	draft	draft	NOUN
dti-1378	411	24	of	of	ADP
dti-1378	411	25	the	the	DET
dti-1378	411	26	manuscript	manuscript	NOUN
dti-1378	411	27	:	:	PUNCT
dti-1378	411	28	anm	anm	PROPN
dti-1378	411	29	.	.	PROPN
dti-1378	411	30	contributed	contribute	VERB
dti-1378	411	31	to	to	ADP
dti-1378	411	32	the	the	DET
dti-1378	411	33	writing	writing	NOUN
dti-1378	411	34	of	of	ADP
dti-1378	411	35	the	the	DET
dti-1378	411	36	manuscript	manuscript	NOUN
dti-1378	411	37	:	:	PUNCT
dti-1378	411	38	rdi	rdi	PROPN
dti-1378	411	39	,	,	PUNCT
dti-1378	411	40	hlk	hlk	PROPN
dti-1378	411	41	,	,	PUNCT
dti-1378	411	42	ora	ora	PROPN
dti-1378	411	43	.	.	PROPN
dti-1378	411	44	agree	agree	VERB
dti-1378	411	45	with	with	ADP
dti-1378	411	46	manuscript	manuscript	NOUN
dti-1378	411	47	results	result	NOUN
dti-1378	411	48	and	and	CCONJ
dti-1378	411	49	conclusions	conclusion	NOUN
dti-1378	411	50	:	:	PUNCT
dti-1378	411	51	anm	anm	PROPN
dti-1378	411	52	,	,	PUNCT
dti-1378	411	53	rdi	rdi	PROPN
dti-1378	411	54	,	,	PUNCT
dti-1378	411	55	hlk	hlk	PROPN
dti-1378	411	56	,	,	PUNCT
dti-1378	411	57	ora	ora	PROPN
dti-1378	411	58	.	.	PROPN
dti-1378	411	59	jointly	jointly	ADV
dti-1378	411	60	developed	develop	VERB
dti-1378	411	61	the	the	DET
dti-1378	411	62	structure	structure	NOUN
dti-1378	411	63	and	and	CCONJ
dti-1378	411	64	arguments	argument	NOUN
dti-1378	411	65	for	for	ADP
dti-1378	411	66	the	the	DET
dti-1378	411	67	paper	paper	NOUN
dti-1378	411	68	:	:	PUNCT
dti-1378	411	69	anm	anm	PROPN
dti-1378	411	70	,	,	PUNCT
dti-1378	411	71	rdi	rdi	PROPN
dti-1378	411	72	,	,	PUNCT
dti-1378	411	73	hlk	hlk	PROPN
dti-1378	411	74	,	,	PUNCT
dti-1378	411	75	ora	ora	PROPN
dti-1378	411	76	.	.	PUNCT
dti-1378	411	77	made	make	VERB
dti-1378	411	78	critical	critical	ADJ
dti-1378	411	79	revisions	revision	NOUN
dti-1378	411	80	and	and	CCONJ
dti-1378	411	81	approved	approve	VERB
dti-1378	411	82	final	final	ADJ
dti-1378	411	83	version	version	NOUN
dti-1378	411	84	:	:	PUNCT
dti-1378	411	85	anm	anm	PROPN
dti-1378	411	86	,	,	PUNCT
dti-1378	411	87	rdi	rdi	PROPN
dti-1378	411	88	,	,	PUNCT
dti-1378	411	89	hlk	hlk	PROPN
dti-1378	411	90	,	,	PUNCT
dti-1378	411	91	ora	ora	PROPN
dti-1378	411	92	.	.	PUNCT
dti-1378	412	1	all	all	DET
dti-1378	412	2	authors	author	NOUN
dti-1378	412	3	reviewed	review	VERB
dti-1378	412	4	and	and	CCONJ
dti-1378	412	5	approved	approve	VERB
dti-1378	412	6	of	of	ADP
dti-1378	412	7	the	the	DET
dti-1378	412	8	final	final	ADJ
dti-1378	412	9	manuscript	manuscript	NOUN
dti-1378	412	10	.	.	PUNCT
dti-1378	413	1	disclosures	disclosure	NOUN
dti-1378	413	2	and	and	CCONJ
dti-1378	413	3	ethics	ethic	NOUN
dti-1378	413	4	as	as	ADP
dti-1378	413	5	a	a	DET
dti-1378	413	6	requirement	requirement	NOUN
dti-1378	413	7	of	of	ADP
dti-1378	413	8	publication	publication	NOUN
dti-1378	413	9	author(s	author(s	PROPN
dti-1378	413	10	)	)	PUNCT
dti-1378	413	11	have	have	AUX
dti-1378	413	12	provided	provide	VERB
dti-1378	413	13	to	to	ADP
dti-1378	413	14	the	the	DET
dti-1378	413	15	publisher	publisher	NOUN
dti-1378	413	16	signed	sign	VERB
dti-1378	413	17	confirmation	confirmation	NOUN
dti-1378	413	18	of	of	ADP
dti-1378	413	19	compliance	compliance	NOUN
dti-1378	413	20	with	with	ADP
dti-1378	413	21	legal	legal	ADJ
dti-1378	413	22	and	and	CCONJ
dti-1378	413	23	ethical	ethical	ADJ
dti-1378	413	24	obligations	obligation	NOUN
dti-1378	413	25	including	include	VERB
dti-1378	413	26	but	but	CCONJ
dti-1378	413	27	not	not	PART
dti-1378	413	28	limited	limit	VERB
dti-1378	413	29	to	to	ADP
dti-1378	413	30	the	the	DET
dti-1378	413	31	following	following	NOUN
dti-1378	413	32	:	:	PUNCT
dti-1378	413	33	authorship	authorship	NOUN
dti-1378	413	34	and	and	CCONJ
dti-1378	413	35	contributorship	contributorship	NOUN
dti-1378	413	36	,	,	PUNCT
dti-1378	413	37	conflicts	conflict	NOUN
dti-1378	413	38	of	of	ADP
dti-1378	413	39	interest	interest	NOUN
dti-1378	413	40	,	,	PUNCT
dti-1378	413	41	privacy	privacy	NOUN
dti-1378	413	42	and	and	CCONJ
dti-1378	413	43	confidentiality	confidentiality	NOUN
dti-1378	413	44	and	and	CCONJ
dti-1378	413	45	(	(	PUNCT
dti-1378	413	46	where	where	SCONJ
dti-1378	413	47	applicable	applicable	ADJ
dti-1378	413	48	)	)	PUNCT
dti-1378	413	49	protection	protection	NOUN
dti-1378	413	50	of	of	ADP
dti-1378	413	51	human	human	ADJ
dti-1378	413	52	and	and	CCONJ
dti-1378	413	53	animal	animal	NOUN
dti-1378	413	54	research	research	NOUN
dti-1378	413	55	subjects	subject	NOUN
dti-1378	413	56	.	.	PUNCT
dti-1378	414	1	the	the	DET
dti-1378	414	2	authors	author	NOUN
dti-1378	414	3	have	have	AUX
dti-1378	414	4	read	read	VERB
dti-1378	414	5	and	and	CCONJ
dti-1378	414	6	confirmed	confirm	VERB
dti-1378	414	7	their	their	PRON
dti-1378	414	8	agreement	agreement	NOUN
dti-1378	414	9	with	with	ADP
dti-1378	414	10	the	the	DET
dti-1378	414	11	icmje	icmje	NOUN
dti-1378	414	12	authorship	authorship	NOUN
dti-1378	414	13	and	and	CCONJ
dti-1378	414	14	conflict	conflict	NOUN
dti-1378	414	15	of	of	ADP
dti-1378	414	16	interest	interest	NOUN
dti-1378	414	17	criteria	criterion	NOUN
dti-1378	414	18	.	.	PUNCT
dti-1378	415	1	the	the	DET
dti-1378	415	2	authors	author	NOUN
dti-1378	415	3	have	have	AUX
dti-1378	415	4	also	also	ADV
dti-1378	415	5	confirmed	confirm	VERB
dti-1378	415	6	that	that	SCONJ
dti-1378	415	7	this	this	DET
dti-1378	415	8	article	article	NOUN
dti-1378	415	9	is	be	AUX
dti-1378	415	10	unique	unique	ADJ
dti-1378	415	11	and	and	CCONJ
dti-1378	415	12	not	not	PART
dti-1378	415	13	under	under	ADP
dti-1378	415	14	consideration	consideration	NOUN
dti-1378	415	15	or	or	CCONJ
dti-1378	415	16	published	publish	VERB
dti-1378	415	17	in	in	ADP
dti-1378	415	18	any	any	DET
dti-1378	415	19	other	other	ADJ
dti-1378	415	20	publication	publication	NOUN
dti-1378	415	21	,	,	PUNCT
dti-1378	415	22	and	and	CCONJ
dti-1378	415	23	that	that	SCONJ
dti-1378	415	24	they	they	PRON
dti-1378	415	25	have	have	VERB
dti-1378	415	26	permission	permission	NOUN
dti-1378	415	27	from	from	ADP
dti-1378	415	28	rights	right	NOUN
dti-1378	415	29	holders	holder	NOUN
dti-1378	415	30	to	to	PART
dti-1378	415	31	reproduce	reproduce	VERB
dti-1378	415	32	any	any	DET
dti-1378	415	33	copyrighted	copyright	VERB
dti-1378	415	34	material	material	NOUN
dti-1378	415	35	.	.	PUNCT
dti-1378	416	1	any	any	DET
dti-1378	416	2	disclosures	disclosure	NOUN
dti-1378	416	3	are	be	AUX
dti-1378	416	4	made	make	VERB
dti-1378	416	5	in	in	ADP
dti-1378	416	6	this	this	DET
dti-1378	416	7	section	section	NOUN
dti-1378	416	8	.	.	PUNCT
dti-1378	417	1	the	the	DET
dti-1378	417	2	external	external	ADJ
dti-1378	417	3	blind	blind	ADJ
dti-1378	417	4	peer	peer	NOUN
dti-1378	417	5	reviewers	reviewer	NOUN
dti-1378	417	6	report	report	VERB
dti-1378	417	7	no	no	DET
dti-1378	417	8	conflicts	conflict	NOUN
dti-1378	417	9	of	of	ADP
dti-1378	417	10	interest	interest	NOUN
dti-1378	417	11	.	.	PUNCT
dti-1378	418	1	references	reference	NOUN
dti-1378	418	2	1	1	NUM
dti-1378	418	3	.	.	PUNCT
dti-1378	418	4	borch	borch	PROPN
dti-1378	418	5	m	m	PROPN
dti-1378	418	6	,	,	PUNCT
dti-1378	418	7	kiernan	kiernan	PROPN
dti-1378	418	8	m	m	PROPN
dti-1378	418	9	,	,	PUNCT
dti-1378	418	10	rust	rust	PROPN
dti-1378	418	11	k	k	PROPN
dti-1378	418	12	,	,	PUNCT
dti-1378	418	13	et	et	PROPN
dti-1378	418	14	al	al	PROPN
dti-1378	418	15	.	.	PUNCT
dti-1378	419	1	schistosomiasis	schistosomiasis	NOUN
dti-1378	419	2	:	:	PUNCT
dti-1378	419	3	a	a	DET
dti-1378	419	4	case	case	NOUN
dti-1378	419	5	study	study	NOUN
dti-1378	419	6	.	.	PUNCT
dti-1378	420	1	urol	urol	PROPN
dti-1378	420	2	nurs	nurs	PROPN
dti-1378	420	3	.	.	PUNCT
dti-1378	421	1	2009;29(1):26–9	2009;29(1):26–9	VERB
dti-1378	421	2	.	.	PUNCT
dti-1378	422	1	2	2	X
dti-1378	422	2	.	.	X
dti-1378	422	3	brindley	brindley	PROPN
dti-1378	422	4	pj	pj	PROPN
dti-1378	422	5	,	,	PUNCT
dti-1378	422	6	mitreva	mitreva	PROPN
dti-1378	422	7	m	m	PROPN
dti-1378	422	8	,	,	PUNCT
dti-1378	422	9	ghedin	ghedin	VERB
dti-1378	422	10	e	e	NOUN
dti-1378	422	11	,	,	PUNCT
dti-1378	422	12	lustigman	lustigman	PROPN
dti-1378	422	13	s.	s.	PROPN
dti-1378	422	14	helminth	helminth	PROPN
dti-1378	422	15	genomics	genomic	NOUN
dti-1378	422	16	:	:	PUNCT
dti-1378	422	17	the	the	DET
dti-1378	422	18	implications	implication	NOUN
dti-1378	422	19	for	for	ADP
dti-1378	422	20	human	human	ADJ
dti-1378	422	21	health	health	NOUN
dti-1378	422	22	.	.	PUNCT
dti-1378	423	1	plos	plos	PROPN
dti-1378	423	2	negl	negl	PROPN
dti-1378	423	3	trop	trop	X
dti-1378	423	4	dis	dis	PROPN
dti-1378	423	5	.	.	PUNCT
dti-1378	424	1	2009;3(10):e538	2009;3(10):e538	NUM
dti-1378	424	2	.	.	NOUN
dti-1378	425	1	3	3	NUM
dti-1378	425	2	.	.	X
dti-1378	425	3	melman	melman	PROPN
dti-1378	425	4	sd	sd	PROPN
dti-1378	425	5	,	,	PUNCT
dti-1378	425	6	steinauer	steinauer	NOUN
dti-1378	425	7	ml	ml	PROPN
dti-1378	425	8	,	,	PUNCT
dti-1378	425	9	cunningham	cunningham	PROPN
dti-1378	425	10	c	c	AUX
dti-1378	425	11	,	,	PUNCT
dti-1378	425	12	et	et	PROPN
dti-1378	425	13	al	al	PROPN
dti-1378	425	14	.	.	PROPN
dti-1378	425	15	reduced	reduce	VERB
dti-1378	425	16	susceptibility	susceptibility	NOUN
dti-1378	425	17	to	to	PART
dti-1378	425	18	praziquantel	praziquantel	VERB
dti-1378	425	19	among	among	ADP
dti-1378	425	20	naturally	naturally	ADV
dti-1378	425	21	occurring	occur	VERB
dti-1378	425	22	kenyan	kenyan	ADJ
dti-1378	425	23	isolates	isolate	NOUN
dti-1378	425	24	of	of	ADP
dti-1378	425	25	schistosoma	schistosoma	ADJ
dti-1378	425	26	mansoni	mansoni	NOUN
dti-1378	425	27	.	.	PUNCT
dti-1378	426	1	plos	plos	PROPN
dti-1378	426	2	negl	negl	PROPN
dti-1378	426	3	trop	trop	X
dti-1378	426	4	dis	dis	PROPN
dti-1378	426	5	.	.	PUNCT
dti-1378	427	1	2009;3(8):e504	2009;3(8):e504	ADJ
dti-1378	427	2	.	.	PUNCT
dti-1378	428	1	4	4	X
dti-1378	428	2	.	.	X
dti-1378	428	3	doenhoff	doenhoff	PROPN
dti-1378	428	4	mj	mj	PROPN
dti-1378	428	5	,	,	PUNCT
dti-1378	428	6	kusel	kusel	PROPN
dti-1378	428	7	jr	jr	PROPN
dti-1378	428	8	,	,	PUNCT
dti-1378	428	9	coles	coles	PROPN
dti-1378	428	10	gc	gc	PROPN
dti-1378	428	11	,	,	PUNCT
dti-1378	428	12	cioli	cioli	PROPN
dti-1378	428	13	d.	d.	PROPN
dti-1378	428	14	resistance	resistance	NOUN
dti-1378	428	15	of	of	ADP
dti-1378	428	16	schistosoma	schistosoma	ADJ
dti-1378	428	17	mansoni	mansoni	NOUN
dti-1378	428	18	to	to	ADP
dti-1378	428	19	praziquantel	praziquantel	VERB
dti-1378	428	20	:	:	PUNCT
dti-1378	428	21	is	be	AUX
dti-1378	428	22	there	there	PRON
dti-1378	428	23	a	a	DET
dti-1378	428	24	problem	problem	NOUN
dti-1378	428	25	?	?	PUNCT
dti-1378	429	1	trans	trans	PROPN
dti-1378	429	2	r	r	NOUN
dti-1378	429	3	soc	soc	PROPN
dti-1378	429	4	trop	trop	X
dti-1378	429	5	med	med	PROPN
dti-1378	429	6	hyg	hyg	PROPN
dti-1378	429	7	.	.	PUNCT
dti-1378	430	1	2002;96(5):465–9	2002;96(5):465–9	NUM
dti-1378	430	2	.	.	PUNCT
dti-1378	431	1	5	5	NUM
dti-1378	431	2	.	.	X
dti-1378	431	3	berriman	berriman	PROPN
dti-1378	431	4	m	m	PROPN
dti-1378	431	5	,	,	PUNCT
dti-1378	431	6	haas	haas	PROPN
dti-1378	431	7	bj	bj	PROPN
dti-1378	431	8	,	,	PUNCT
dti-1378	431	9	loverde	loverde	PROPN
dti-1378	431	10	pt	pt	PROPN
dti-1378	431	11	,	,	PUNCT
dti-1378	431	12	et	et	PROPN
dti-1378	431	13	al	al	PROPN
dti-1378	431	14	.	.	PUNCT
dti-1378	432	1	the	the	DET
dti-1378	432	2	genome	genome	NOUN
dti-1378	432	3	of	of	ADP
dti-1378	432	4	the	the	DET
dti-1378	432	5	blood	blood	NOUN
dti-1378	432	6	fluke	fluke	NOUN
dti-1378	432	7	schistosoma	schistosoma	ADJ
dti-1378	432	8	mansoni	mansoni	ADJ
dti-1378	432	9	.	.	PUNCT
dti-1378	433	1	nature	nature	NOUN
dti-1378	433	2	.	.	PUNCT
dti-1378	434	1	2009;460(7253):352–8	2009;460(7253):352–8	X
dti-1378	434	2	.	.	X
dti-1378	434	3	6	6	NUM
dti-1378	434	4	.	.	X
dti-1378	434	5	crowther	crowther	PROPN
dti-1378	434	6	gj	gj	PROPN
dti-1378	434	7	,	,	PUNCT
dti-1378	434	8	shanmugam	shanmugam	PROPN
dti-1378	434	9	d	d	PROPN
dti-1378	434	10	,	,	PUNCT
dti-1378	434	11	carmona	carmona	PROPN
dti-1378	434	12	sj	sj	PROPN
dti-1378	434	13	,	,	PUNCT
dti-1378	434	14	et	et	PROPN
dti-1378	434	15	al	al	PROPN
dti-1378	434	16	.	.	PUNCT
dti-1378	434	17	identification	identification	NOUN
dti-1378	434	18	of	of	ADP
dti-1378	434	19	attractive	attractive	ADJ
dti-1378	434	20	drug	drug	NOUN
dti-1378	434	21	targets	target	NOUN
dti-1378	434	22	in	in	ADP
dti-1378	434	23	neglected	neglect	VERB
dti-1378	434	24	-	-	PUNCT
dti-1378	434	25	disease	disease	NOUN
dti-1378	434	26	pathogens	pathogen	NOUN
dti-1378	434	27	using	use	VERB
dti-1378	434	28	an	an	DET
dti-1378	434	29	in	in	ADP
dti-1378	434	30	silico	silico	NOUN
dti-1378	434	31	approach	approach	NOUN
dti-1378	434	32	.	.	PUNCT
dti-1378	435	1	plos	plos	PROPN
dti-1378	435	2	negl	negl	PROPN
dti-1378	435	3	trop	trop	X
dti-1378	435	4	dis	dis	PROPN
dti-1378	435	5	.	.	PUNCT
dti-1378	435	6	2010;4(8):e804	2010;4(8):e804	NOUN
dti-1378	435	7	.	.	PUNCT
dti-1378	436	1	7	7	X
dti-1378	436	2	.	.	X
dti-1378	436	3	gobert	gobert	PROPN
dti-1378	436	4	gn	gn	PROPN
dti-1378	436	5	,	,	PUNCT
dti-1378	436	6	moertel	moertel	NOUN
dti-1378	436	7	l	l	NOUN
dti-1378	436	8	,	,	PUNCT
dti-1378	436	9	brindley	brindley	PROPN
dti-1378	436	10	pj	pj	PROPN
dti-1378	436	11	,	,	PUNCT
dti-1378	436	12	mcmanus	mcmanus	PROPN
dti-1378	436	13	dp	dp	PROPN
dti-1378	436	14	.	.	PUNCT
dti-1378	436	15	developmental	developmental	ADJ
dti-1378	436	16	gene	gene	NOUN
dti-1378	436	17	expression	expression	NOUN
dti-1378	436	18	profiles	profile	NOUN
dti-1378	436	19	of	of	ADP
dti-1378	436	20	the	the	DET
dti-1378	436	21	human	human	ADJ
dti-1378	436	22	pathogen	pathogen	NOUN
dti-1378	436	23	schistosoma	schistosoma	ADJ
dti-1378	436	24	japonicum	japonicum	NOUN
dti-1378	436	25	.	.	PUNCT
dti-1378	437	1	bmc	bmc	NOUN
dti-1378	437	2	genomics	genomic	NOUN
dti-1378	437	3	.	.	PUNCT
dti-1378	438	1	2009;10:128	2009;10:128	X
dti-1378	438	2	.	.	NOUN
dti-1378	438	3	8	8	NUM
dti-1378	438	4	.	.	X
dti-1378	438	5	jolly	jolly	ADV
dti-1378	438	6	er	er	INTJ
dti-1378	438	7	,	,	PUNCT
dti-1378	438	8	chin	chin	PROPN
dti-1378	438	9	cs	cs	PROPN
dti-1378	438	10	,	,	PUNCT
dti-1378	438	11	miller	miller	PROPN
dti-1378	438	12	s	s	PROPN
dti-1378	438	13	,	,	PUNCT
dti-1378	438	14	et	et	PROPN
dti-1378	438	15	al	al	PROPN
dti-1378	438	16	.	.	PUNCT
dti-1378	438	17	gene	gene	NOUN
dti-1378	438	18	expression	expression	NOUN
dti-1378	438	19	patterns	pattern	NOUN
dti-1378	438	20	during	during	ADP
dti-1378	438	21	adaptation	adaptation	NOUN
dti-1378	438	22	of	of	ADP
dti-1378	438	23	a	a	DET
dti-1378	438	24	helminth	helminth	NOUN
dti-1378	438	25	parasite	parasite	NOUN
dti-1378	438	26	to	to	ADP
dti-1378	438	27	different	different	ADJ
dti-1378	438	28	environmental	environmental	ADJ
dti-1378	438	29	niches	niche	NOUN
dti-1378	438	30	.	.	PUNCT
dti-1378	439	1	genome	genome	NOUN
dti-1378	439	2	biol	biol	NOUN
dti-1378	439	3	.	.	PUNCT
dti-1378	440	1	2007;8(4):r65	2007;8(4):r65	X
dti-1378	440	2	.	.	PUNCT
dti-1378	441	1	9	9	NUM
dti-1378	441	2	.	.	X
dti-1378	441	3	patocka	patocka	PROPN
dti-1378	441	4	n	n	CCONJ
dti-1378	441	5	,	,	PUNCT
dti-1378	441	6	ribeiro	ribeiro	PROPN
dti-1378	441	7	p.	p.	PROPN
dti-1378	441	8	characterization	characterization	NOUN
dti-1378	441	9	of	of	ADP
dti-1378	441	10	a	a	DET
dti-1378	441	11	serotonin	serotonin	NOUN
dti-1378	441	12	transporter	transporter	NOUN
dti-1378	441	13	in	in	ADP
dti-1378	441	14	the	the	DET
dti-1378	441	15	parasitic	parasitic	ADJ
dti-1378	441	16	flatworm	flatworm	NOUN
dti-1378	441	17	,	,	PUNCT
dti-1378	441	18	schistosoma	schistosoma	ADJ
dti-1378	441	19	mansoni	mansoni	ADJ
dti-1378	441	20	:	:	PUNCT
dti-1378	441	21	cloning	cloning	NOUN
dti-1378	441	22	,	,	PUNCT
dti-1378	441	23	expression	expression	NOUN
dti-1378	441	24	and	and	CCONJ
dti-1378	441	25	functional	functional	ADJ
dti-1378	441	26	analysis	analysis	NOUN
dti-1378	441	27	.	.	PUNCT
dti-1378	442	1	mol	mol	ADP
dti-1378	442	2	biochem	biochem	PROPN
dti-1378	442	3	parasitol	parasitol	NOUN
dti-1378	442	4	.	.	PUNCT
dti-1378	443	1	2007;154(2):125–33	2007;154(2):125–33	NUM
dti-1378	443	2	.	.	PUNCT
dti-1378	444	1	10	10	NUM
dti-1378	444	2	.	.	PUNCT
dti-1378	444	3	pax	pax	PROPN
dti-1378	444	4	ra	ra	PROPN
dti-1378	444	5	,	,	PUNCT
dti-1378	444	6	siefker	siefker	PROPN
dti-1378	444	7	c	c	PROPN
dti-1378	444	8	,	,	PUNCT
dti-1378	444	9	bennett	bennett	PROPN
dti-1378	444	10	jl	jl	PROPN
dti-1378	444	11	.	.	PUNCT
dti-1378	445	1	schistosoma	schistosoma	PROPN
dti-1378	445	2	mansoni	mansoni	ADJ
dti-1378	445	3	:	:	PUNCT
dti-1378	445	4	differences	difference	NOUN
dti-1378	445	5	in	in	ADP
dti-1378	445	6	acetylcholine	acetylcholine	NOUN
dti-1378	445	7	,	,	PUNCT
dti-1378	445	8	dopamine	dopamine	NOUN
dti-1378	445	9	,	,	PUNCT
dti-1378	445	10	and	and	CCONJ
dti-1378	445	11	serotonin	serotonin	VERB
dti-1378	445	12	control	control	NOUN
dti-1378	445	13	of	of	ADP
dti-1378	445	14	circular	circular	ADJ
dti-1378	445	15	and	and	CCONJ
dti-1378	445	16	longitudinal	longitudinal	ADJ
dti-1378	445	17	parasite	parasite	ADJ
dti-1378	445	18	muscles	muscle	NOUN
dti-1378	445	19	.	.	PUNCT
dti-1378	446	1	exp	exp	NOUN
dti-1378	446	2	parasitol	parasitol	NOUN
dti-1378	446	3	.	.	PUNCT
dti-1378	447	1	1984;58(3):314–24	1984;58(3):314–24	X
dti-1378	447	2	.	.	PUNCT
dti-1378	448	1	11	11	NUM
dti-1378	448	2	.	.	PUNCT
dti-1378	449	1	wood	wood	PROPN
dti-1378	449	2	pj	pj	PROPN
dti-1378	449	3	,	,	PUNCT
dti-1378	449	4	mansour	mansour	PROPN
dti-1378	449	5	te	te	PROPN
dti-1378	449	6	.	.	PUNCT
dti-1378	450	1	schistosoma	schistosoma	PROPN
dti-1378	450	2	mansoni	mansoni	ADJ
dti-1378	450	3	:	:	PUNCT
dti-1378	450	4	serotonin	serotonin	VERB
dti-1378	450	5	uptake	uptake	ADJ
dti-1378	450	6	and	and	CCONJ
dti-1378	450	7	its	its	PRON
dti-1378	450	8	drug	drug	NOUN
dti-1378	450	9	inhibition	inhibition	NOUN
dti-1378	450	10	.	.	PUNCT
dti-1378	451	1	exp	exp	NOUN
dti-1378	451	2	parasitol	parasitol	NOUN
dti-1378	451	3	.	.	PUNCT
dti-1378	452	1	1986;62(1):114–9	1986;62(1):114–9	NUM
dti-1378	452	2	.	.	PUNCT
dti-1378	453	1	12	12	NUM
dti-1378	453	2	.	.	PUNCT
dti-1378	454	1	boyle	boyle	PROPN
dti-1378	454	2	jp	jp	PROPN
dti-1378	454	3	,	,	PUNCT
dti-1378	454	4	zaide	zaide	PROPN
dti-1378	454	5	jv	jv	PROPN
dti-1378	454	6	,	,	PUNCT
dti-1378	454	7	yoshino	yoshino	ADJ
dti-1378	454	8	tp	tp	NOUN
dti-1378	454	9	.	.	PUNCT
dti-1378	455	1	schistosoma	schistosoma	ADJ
dti-1378	455	2	mansoni	mansoni	ADJ
dti-1378	455	3	:	:	PUNCT
dti-1378	455	4	effects	effect	NOUN
dti-1378	455	5	of	of	ADP
dti-1378	455	6	serotonin	serotonin	NOUN
dti-1378	455	7	and	and	CCONJ
dti-1378	455	8	serotonin	serotonin	VERB
dti-1378	455	9	receptor	receptor	NOUN
dti-1378	455	10	antagonists	antagonist	NOUN
dti-1378	455	11	on	on	ADP
dti-1378	455	12	motility	motility	NOUN
dti-1378	455	13	and	and	CCONJ
dti-1378	455	14	length	length	NOUN
dti-1378	455	15	of	of	ADP
dti-1378	455	16	primary	primary	ADJ
dti-1378	455	17	sporocysts	sporocyst	NOUN
dti-1378	455	18	in	in	ADP
dti-1378	455	19	vitro	vitro	X
dti-1378	455	20	.	.	PUNCT
dti-1378	456	1	exp	exp	NOUN
dti-1378	456	2	parasitol	parasitol	NOUN
dti-1378	456	3	.	.	PUNCT
dti-1378	457	1	2000;94(4):217–26	2000;94(4):217–26	NUM
dti-1378	457	2	.	.	PUNCT
dti-1378	458	1	13	13	NUM
dti-1378	458	2	.	.	PUNCT
dti-1378	459	1	ribeiro	ribeiro	PROPN
dti-1378	459	2	p	p	PROPN
dti-1378	459	3	,	,	PUNCT
dti-1378	459	4	webb	webb	PROPN
dti-1378	459	5	ra	ra	PROPN
dti-1378	459	6	.	.	PUNCT
dti-1378	460	1	the	the	DET
dti-1378	460	2	occurrence	occurrence	NOUN
dti-1378	460	3	,	,	PUNCT
dti-1378	460	4	synthesis	synthesis	NOUN
dti-1378	460	5	and	and	CCONJ
dti-1378	460	6	metabolism	metabolism	NOUN
dti-1378	460	7	of	of	ADP
dti-1378	460	8	5hydroxytryptamine	5hydroxytryptamine	NUM
dti-1378	460	9	and	and	CCONJ
dti-1378	460	10	5	5	NUM
dti-1378	460	11	-	-	PUNCT
dti-1378	460	12	hydroxytryptophan	hydroxytryptophan	NOUN
dti-1378	460	13	in	in	ADP
dti-1378	460	14	the	the	DET
dti-1378	460	15	cestode	cestode	PROPN
dti-1378	460	16	hymenolepis	hymenolepis	PROPN
dti-1378	460	17	diminuta	diminuta	PROPN
dti-1378	460	18	:	:	PUNCT
dti-1378	460	19	a	a	DET
dti-1378	460	20	high	high	ADJ
dti-1378	460	21	performance	performance	NOUN
dti-1378	460	22	liquid	liquid	ADJ
dti-1378	460	23	chromatographic	chromatographic	ADJ
dti-1378	460	24	study	study	NOUN
dti-1378	460	25	.	.	PUNCT
dti-1378	461	1	comp	comp	PROPN
dti-1378	461	2	biochem	biochem	PROPN
dti-1378	461	3	physiol	physiol	PROPN
dti-1378	461	4	c.	c.	PROPN
dti-1378	461	5	1984;79(1):159–64	1984;79(1):159–64	PROPN
dti-1378	461	6	.	.	PUNCT
dti-1378	462	1	14	14	NUM
dti-1378	462	2	.	.	PUNCT
dti-1378	463	1	mettrick	mettrick	PROPN
dti-1378	463	2	df	df	PROPN
dti-1378	463	3	,	,	PUNCT
dti-1378	463	4	rahman	rahman	PROPN
dti-1378	463	5	ms	ms	PROPN
dti-1378	463	6	,	,	PUNCT
dti-1378	463	7	podesta	podesta	PROPN
dti-1378	463	8	rb	rb	PROPN
dti-1378	463	9	.	.	PUNCT
dti-1378	463	10	effect	effect	NOUN
dti-1378	463	11	of	of	ADP
dti-1378	463	12	5	5	NUM
dti-1378	463	13	-	-	PUNCT
dti-1378	463	14	hydroxytryptamine	hydroxytryptamine	NOUN
dti-1378	463	15	(	(	PUNCT
dti-1378	463	16	5	5	NUM
dti-1378	463	17	-	-	SYM
dti-1378	463	18	ht	ht	NOUN
dti-1378	463	19	;	;	PUNCT
dti-1378	463	20	serotonin	serotonin	NOUN
dti-1378	463	21	)	)	PUNCT
dti-1378	463	22	on	on	ADP
dti-1378	463	23	in	in	ADP
dti-1378	463	24	vitro	vitro	X
dti-1378	463	25	glucose	glucose	NOUN
dti-1378	463	26	uptake	uptake	ADJ
dti-1378	463	27	and	and	CCONJ
dti-1378	463	28	glycogen	glycogen	NOUN
dti-1378	463	29	reserves	reserve	NOUN
dti-1378	463	30	in	in	ADP
dti-1378	463	31	hymenolepis	hymenolepis	PROPN
dti-1378	463	32	diminuta	diminuta	PROPN
dti-1378	463	33	.	.	PUNCT
dti-1378	464	1	mol	mol	ADP
dti-1378	464	2	biochem	biochem	PROPN
dti-1378	464	3	parasitol	parasitol	NOUN
dti-1378	464	4	.	.	PUNCT
dti-1378	465	1	1981;4(3–4):217–23	1981;4(3–4):217–23	X
dti-1378	465	2	.	.	PROPN
dti-1378	465	3	15	15	NUM
dti-1378	465	4	.	.	PUNCT
dti-1378	465	5	boyle	boyle	PROPN
dti-1378	465	6	jp	jp	PROPN
dti-1378	465	7	,	,	PUNCT
dti-1378	465	8	hillyer	hillyer	PROPN
dti-1378	465	9	jf	jf	PROPN
dti-1378	465	10	,	,	PUNCT
dti-1378	465	11	yoshino	yoshino	PROPN
dti-1378	465	12	tp	tp	NOUN
dti-1378	465	13	.	.	PUNCT
dti-1378	465	14	pharmacological	pharmacological	ADJ
dti-1378	465	15	and	and	CCONJ
dti-1378	465	16	autoradiographical	autoradiographical	ADJ
dti-1378	465	17	characterization	characterization	NOUN
dti-1378	465	18	of	of	ADP
dti-1378	465	19	serotonin	serotonin	ADJ
dti-1378	465	20	transporter	transporter	NOUN
dti-1378	465	21	-	-	PUNCT
dti-1378	465	22	like	like	ADJ
dti-1378	465	23	activity	activity	NOUN
dti-1378	465	24	in	in	ADP
dti-1378	465	25	sporocysts	sporocyst	NOUN
dti-1378	465	26	of	of	ADP
dti-1378	465	27	the	the	DET
dti-1378	465	28	human	human	ADJ
dti-1378	465	29	blood	blood	NOUN
dti-1378	465	30	fluke	fluke	NOUN
dti-1378	465	31	,	,	PUNCT
dti-1378	465	32	schistosoma	schistosoma	ADJ
dti-1378	465	33	mansoni	mansoni	ADJ
dti-1378	465	34	.	.	PUNCT
dti-1378	466	1	j	j	PROPN
dti-1378	466	2	comp	comp	PROPN
dti-1378	466	3	physiol	physiol	PROPN
dti-1378	466	4	a	a	DET
dti-1378	466	5	neuroethol	neuroethol	PROPN
dti-1378	466	6	sens	sens	PROPN
dti-1378	466	7	neural	neural	PROPN
dti-1378	466	8	behav	behav	PROPN
dti-1378	466	9	physiol	physiol	PROPN
dti-1378	466	10	.	.	PUNCT
dti-1378	467	1	2003;189(8):631–41	2003;189(8):631–41	NUM
dti-1378	467	2	.	.	PUNCT
dti-1378	468	1	16	16	NUM
dti-1378	468	2	.	.	PUNCT
dti-1378	469	1	gustafsson	gustafsson	PROPN
dti-1378	469	2	mk	mk	PROPN
dti-1378	469	3	.	.	PUNCT
dti-1378	470	1	immunocytochemical	immunocytochemical	ADJ
dti-1378	470	2	demonstration	demonstration	NOUN
dti-1378	470	3	of	of	ADP
dti-1378	470	4	neuropeptides	neuropeptide	NOUN
dti-1378	470	5	and	and	CCONJ
dti-1378	470	6	serotonin	serotonin	VERB
dti-1378	470	7	in	in	ADP
dti-1378	470	8	the	the	DET
dti-1378	470	9	nervous	nervous	ADJ
dti-1378	470	10	systems	system	NOUN
dti-1378	470	11	of	of	ADP
dti-1378	470	12	adult	adult	NOUN
dti-1378	470	13	schistosoma	schistosoma	ADJ
dti-1378	470	14	mansoni	mansoni	NOUN
dti-1378	470	15	.	.	PUNCT
dti-1378	471	1	parasitol	parasitol	NOUN
dti-1378	471	2	res	re	NOUN
dti-1378	471	3	.	.	PUNCT
dti-1378	472	1	1987;74(2):168–74	1987;74(2):168–74	NUM
dti-1378	472	2	.	.	NOUN
dti-1378	472	3	17	17	NUM
dti-1378	472	4	.	.	PUNCT
dti-1378	473	1	rothman	rothman	PROPN
dti-1378	473	2	rb	rb	PROPN
dti-1378	473	3	,	,	PUNCT
dti-1378	473	4	glowa	glowa	PROPN
dti-1378	473	5	jr	jr	PROPN
dti-1378	473	6	.	.	PUNCT
dti-1378	474	1	a	a	DET
dti-1378	474	2	review	review	NOUN
dti-1378	474	3	of	of	ADP
dti-1378	474	4	the	the	DET
dti-1378	474	5	effects	effect	NOUN
dti-1378	474	6	of	of	ADP
dti-1378	474	7	dopaminergic	dopaminergic	ADJ
dti-1378	474	8	agents	agent	NOUN
dti-1378	474	9	on	on	ADP
dti-1378	474	10	humans	human	NOUN
dti-1378	474	11	,	,	PUNCT
dti-1378	474	12	animals	animal	NOUN
dti-1378	474	13	,	,	PUNCT
dti-1378	474	14	and	and	CCONJ
dti-1378	474	15	drug	drug	NOUN
dti-1378	474	16	-	-	PUNCT
dti-1378	474	17	seeking	seek	VERB
dti-1378	474	18	behavior	behavior	NOUN
dti-1378	474	19	,	,	PUNCT
dti-1378	474	20	and	and	CCONJ
dti-1378	474	21	its	its	PRON
dti-1378	474	22	implications	implication	NOUN
dti-1378	474	23	for	for	ADP
dti-1378	474	24	medication	medication	NOUN
dti-1378	474	25	development	development	NOUN
dti-1378	474	26	.	.	PUNCT
dti-1378	475	1	focus	focus	VERB
dti-1378	475	2	on	on	ADP
dti-1378	475	3	gbr	gbr	PROPN
dti-1378	475	4	12909	12909	NUM
dti-1378	475	5	.	.	PUNCT
dti-1378	476	1	mol	mol	ADP
dti-1378	476	2	neurobiol	neurobiol	NOUN
dti-1378	476	3	.	.	PUNCT
dti-1378	477	1	1995;11(1–3):1–19	1995;11(1–3):1–19	NUM
dti-1378	477	2	.	.	PUNCT
dti-1378	478	1	18	18	NUM
dti-1378	478	2	.	.	PUNCT
dti-1378	479	1	rahman	rahman	PROPN
dti-1378	479	2	ms	ms	PROPN
dti-1378	479	3	,	,	PUNCT
dti-1378	479	4	mettrick	mettrick	NOUN
dti-1378	479	5	df	df	PROPN
dti-1378	479	6	,	,	PUNCT
dti-1378	479	7	podesta	podesta	PROPN
dti-1378	479	8	rb	rb	PROPN
dti-1378	479	9	.	.	PUNCT
dti-1378	480	1	schistosoma	schistosoma	ADJ
dti-1378	480	2	mansoni	mansoni	ADJ
dti-1378	480	3	:	:	PUNCT
dti-1378	480	4	effects	effect	NOUN
dti-1378	480	5	of	of	ADP
dti-1378	480	6	in	in	ADP
dti-1378	480	7	vitro	vitro	X
dti-1378	480	8	serotonin	serotonin	NOUN
dti-1378	480	9	(	(	PUNCT
dti-1378	480	10	5	5	NUM
dti-1378	480	11	-	-	SYM
dti-1378	480	12	ht	ht	NOUN
dti-1378	480	13	)	)	PUNCT
dti-1378	480	14	on	on	ADP
dti-1378	480	15	aerobic	aerobic	ADJ
dti-1378	480	16	and	and	CCONJ
dti-1378	480	17	anaerobic	anaerobic	ADJ
dti-1378	480	18	carbohydrate	carbohydrate	NOUN
dti-1378	480	19	metabolism	metabolism	NOUN
dti-1378	480	20	.	.	PUNCT
dti-1378	481	1	exp	exp	NOUN
dti-1378	481	2	parasitol	parasitol	NOUN
dti-1378	481	3	.	.	PUNCT
dti-1378	482	1	1985;60(1):10–7	1985;60(1):10–7	NUM
dti-1378	482	2	.	.	PUNCT
dti-1378	482	3	http://www.la-press.com	http://www.la-press.com	X
dti-1378	483	1	mbah	mbah	PROPN
dti-1378	483	2	et	et	PROPN
dti-1378	483	3	al	al	PROPN
dti-1378	483	4	58	58	NUM
dti-1378	483	5	drug	drug	NOUN
dti-1378	483	6	target	target	NOUN
dti-1378	483	7	insights	insight	NOUN
dti-1378	483	8	2012:6	2012:6	NUM
dti-1378	483	9	19	19	NUM
dti-1378	483	10	.	.	PUNCT
dti-1378	484	1	bayne	bayne	PROPN
dti-1378	484	2	cj	cj	PROPN
dti-1378	484	3	,	,	PUNCT
dti-1378	484	4	grevelding	grevelde	VERB
dti-1378	484	5	cg	cg	NOUN
dti-1378	484	6	.	.	PUNCT
dti-1378	485	1	cloning	cloning	NOUN
dti-1378	485	2	of	of	ADP
dti-1378	485	3	schistosoma	schistosoma	ADJ
dti-1378	485	4	mansoni	mansoni	ADJ
dti-1378	485	5	sporocysts	sporocyst	NOUN
dti-1378	485	6	in	in	ADP
dti-1378	485	7	vitro	vitro	NOUN
dti-1378	485	8	and	and	CCONJ
dti-1378	485	9	detection	detection	NOUN
dti-1378	485	10	of	of	ADP
dti-1378	485	11	genetic	genetic	ADJ
dti-1378	485	12	heterogeneity	heterogeneity	NOUN
dti-1378	485	13	among	among	ADP
dti-1378	485	14	individuals	individual	NOUN
dti-1378	485	15	within	within	ADP
dti-1378	485	16	clones	clone	NOUN
dti-1378	485	17	.	.	PUNCT
dti-1378	486	1	j	j	PROPN
dti-1378	486	2	parasitol	parasitol	NOUN
dti-1378	486	3	.	.	PUNCT
dti-1378	487	1	2003;89(5):1056–60	2003;89(5):1056–60	NOUN
dti-1378	487	2	.	.	PUNCT
dti-1378	488	1	20	20	NUM
dti-1378	488	2	.	.	PUNCT
dti-1378	489	1	samuelson	samuelson	PROPN
dti-1378	489	2	jc	jc	PROPN
dti-1378	489	3	,	,	PUNCT
dti-1378	489	4	quinn	quinn	PROPN
dti-1378	489	5	jj	jj	PROPN
dti-1378	489	6	,	,	PUNCT
dti-1378	489	7	caulfield	caulfield	PROPN
dti-1378	489	8	jp	jp	PROPN
dti-1378	489	9	.	.	PUNCT
dti-1378	490	1	hatching	hatch	VERB
dti-1378	490	2	,	,	PUNCT
dti-1378	490	3	chemokinesis	chemokinesis	NOUN
dti-1378	490	4	,	,	PUNCT
dti-1378	490	5	and	and	CCONJ
dti-1378	490	6	transformation	transformation	NOUN
dti-1378	490	7	of	of	ADP
dti-1378	490	8	miracidia	miracidia	PROPN
dti-1378	490	9	of	of	ADP
dti-1378	490	10	schistosoma	schistosoma	ADJ
dti-1378	490	11	mansoni	mansoni	NOUN
dti-1378	490	12	.	.	PUNCT
dti-1378	491	1	j	j	PROPN
dti-1378	491	2	parasitol	parasitol	NOUN
dti-1378	491	3	.	.	PUNCT
dti-1378	492	1	1984;70(3	1984;70(3	NUM
dti-1378	492	2	):	):	PUNCT
dti-1378	492	3	321–31	321–31	PROPN
dti-1378	492	4	.	.	PROPN
dti-1378	493	1	21	21	NUM
dti-1378	493	2	.	.	PUNCT
dti-1378	494	1	mcnall	mcnall	PROPN
dti-1378	494	2	sj	sj	PROPN
dti-1378	494	3	,	,	PUNCT
dti-1378	494	4	mansour	mansour	PROPN
dti-1378	494	5	te	te	PROPN
dti-1378	494	6	.	.	PUNCT
dti-1378	494	7	novel	novel	NOUN
dti-1378	494	8	serotonin	serotonin	NOUN
dti-1378	494	9	receptors	receptor	NOUN
dti-1378	494	10	in	in	ADP
dti-1378	494	11	fasciola	fasciola	PROPN
dti-1378	494	12	.	.	PUNCT
dti-1378	495	1	characterization	characterization	NOUN
dti-1378	495	2	by	by	ADP
dti-1378	495	3	studies	study	NOUN
dti-1378	495	4	on	on	ADP
dti-1378	495	5	adenylate	adenylate	ADJ
dti-1378	495	6	cyclase	cyclase	NOUN
dti-1378	495	7	activation	activation	NOUN
dti-1378	495	8	and	and	CCONJ
dti-1378	495	9	[	[	X
dti-1378	495	10	3h]lsd	3h]lsd	NUM
dti-1378	495	11	binding	binding	ADJ
dti-1378	495	12	.	.	PUNCT
dti-1378	496	1	biochem	biochem	PROPN
dti-1378	496	2	pharmacol	pharmacol	PROPN
dti-1378	496	3	.	.	PUNCT
dti-1378	497	1	1984;33(17):2789–97	1984;33(17):2789–97	NUM
dti-1378	497	2	.	.	PUNCT
dti-1378	498	1	22	22	NUM
dti-1378	498	2	.	.	PUNCT
dti-1378	499	1	shiff	shiff	PROPN
dti-1378	499	2	c	c	PROPN
dti-1378	499	3	,	,	PUNCT
dti-1378	499	4	naples	naples	PROPN
dti-1378	499	5	jm	jm	PROPN
dti-1378	499	6	,	,	PUNCT
dti-1378	499	7	isharwal	isharwal	PROPN
dti-1378	499	8	s	s	PROPN
dti-1378	499	9	,	,	PUNCT
dti-1378	499	10	bosompem	bosompem	ADP
dti-1378	499	11	km	km	PROPN
dti-1378	499	12	,	,	PUNCT
dti-1378	499	13	veltri	veltri	PROPN
dti-1378	499	14	rw	rw	PROPN
dti-1378	499	15	.	.	PUNCT
dti-1378	500	1	non	non	ADJ
dti-1378	500	2	-	-	ADJ
dti-1378	500	3	invasive	invasive	ADJ
dti-1378	500	4	methods	method	NOUN
dti-1378	500	5	to	to	PART
dti-1378	500	6	detect	detect	VERB
dti-1378	500	7	schistosome	schistosome	NOUN
dti-1378	500	8	-	-	PUNCT
dti-1378	500	9	based	base	VERB
dti-1378	500	10	bladder	bladder	NOUN
dti-1378	500	11	cancer	cancer	NOUN
dti-1378	500	12	:	:	PUNCT
dti-1378	500	13	is	be	AUX
dti-1378	500	14	the	the	DET
dti-1378	500	15	association	association	NOUN
dti-1378	500	16	sufficient	sufficient	ADJ
dti-1378	500	17	for	for	ADP
dti-1378	500	18	epidemiological	epidemiological	ADJ
dti-1378	500	19	use	use	NOUN
dti-1378	500	20	?	?	PUNCT
dti-1378	501	1	trans	trans	PROPN
dti-1378	501	2	r	r	NOUN
dti-1378	501	3	soc	soc	NOUN
dti-1378	501	4	trop	trop	X
dti-1378	501	5	med	med	PROPN
dti-1378	501	6	hyg	hyg	PROPN
dti-1378	501	7	.	.	PUNCT
dti-1378	501	8	2010;104(1):3–5	2010;104(1):3–5	NUM
dti-1378	501	9	.	.	PROPN
dti-1378	501	10	23	23	NUM
dti-1378	501	11	.	.	PUNCT
dti-1378	502	1	kasschau	kasschau	PROPN
dti-1378	502	2	mr	mr	PROPN
dti-1378	502	3	,	,	PUNCT
dti-1378	502	4	mansour	mansour	PROPN
dti-1378	502	5	te	te	PROPN
dti-1378	502	6	.	.	PUNCT
dti-1378	502	7	serotonin	serotonin	NOUN
dti-1378	502	8	-	-	PUNCT
dti-1378	502	9	activated	activate	VERB
dti-1378	502	10	adenylate	adenylate	ADJ
dti-1378	502	11	cyclase	cyclase	NOUN
dti-1378	502	12	during	during	ADP
dti-1378	502	13	early	early	ADJ
dti-1378	502	14	development	development	NOUN
dti-1378	502	15	of	of	ADP
dti-1378	502	16	schistosoma	schistosoma	ADJ
dti-1378	502	17	mansoni	mansoni	NOUN
dti-1378	502	18	.	.	PUNCT
dti-1378	503	1	nature	nature	NOUN
dti-1378	503	2	.	.	PUNCT
dti-1378	504	1	1982;296(5852	1982;296(5852	NUM
dti-1378	504	2	):	):	PUNCT
dti-1378	505	1	66–8	66–8	PROPN
dti-1378	505	2	.	.	PROPN
dti-1378	505	3	24	24	NUM
dti-1378	505	4	.	.	PUNCT
dti-1378	506	1	weitmann	weitmann	PROPN
dti-1378	506	2	s	s	PART
dti-1378	506	3	,	,	PUNCT
dti-1378	506	4	würsig	würsig	NOUN
dti-1378	506	5	n	n	CCONJ
dti-1378	506	6	,	,	PUNCT
dti-1378	506	7	navarro	navarro	PROPN
dti-1378	506	8	jm	jm	PROPN
dti-1378	506	9	,	,	PUNCT
dti-1378	506	10	kleuss	kleuss	PROPN
dti-1378	506	11	c.	c.	PROPN
dti-1378	506	12	a	a	DET
dti-1378	506	13	functional	functional	ADJ
dti-1378	506	14	chimera	chimera	NOUN
dti-1378	506	15	of	of	ADP
dti-1378	506	16	mammalian	mammalian	ADJ
dti-1378	506	17	guanylyl	guanylyl	NOUN
dti-1378	506	18	and	and	CCONJ
dti-1378	506	19	adenylyl	adenylyl	NOUN
dti-1378	506	20	cyclases	cyclase	NOUN
dti-1378	506	21	.	.	PUNCT
dti-1378	507	1	biochemistry	biochemistry	NOUN
dti-1378	507	2	.	.	PUNCT
dti-1378	508	1	1999;38(11	1999;38(11	NUM
dti-1378	508	2	):	):	PUNCT
dti-1378	508	3	3409–13	3409–13	NOUN
dti-1378	508	4	.	.	PUNCT
dti-1378	509	1	25	25	NUM
dti-1378	509	2	.	.	PUNCT
dti-1378	509	3	kelley	kelley	PROPN
dti-1378	509	4	la	la	PROPN
dti-1378	509	5	,	,	PUNCT
dti-1378	509	6	sternberg	sternberg	PROPN
dti-1378	509	7	mj	mj	PROPN
dti-1378	509	8	.	.	PUNCT
dti-1378	509	9	protein	protein	NOUN
dti-1378	509	10	structure	structure	NOUN
dti-1378	509	11	prediction	prediction	NOUN
dti-1378	509	12	on	on	ADP
dti-1378	509	13	the	the	DET
dti-1378	509	14	web	web	NOUN
dti-1378	509	15	:	:	PUNCT
dti-1378	509	16	a	a	DET
dti-1378	509	17	case	case	NOUN
dti-1378	509	18	study	study	NOUN
dti-1378	509	19	using	use	VERB
dti-1378	509	20	the	the	DET
dti-1378	509	21	phyre	phyre	PROPN
dti-1378	509	22	server	server	PROPN
dti-1378	509	23	.	.	PUNCT
dti-1378	510	1	nature	nature	NOUN
dti-1378	510	2	protoc	protoc	VERB
dti-1378	510	3	.	.	PUNCT
dti-1378	511	1	2009;4(3):363–71	2009;4(3):363–71	NOUN
dti-1378	511	2	.	.	PUNCT
dti-1378	512	1	26	26	NUM
dti-1378	512	2	.	.	PUNCT
dti-1378	513	1	gopalakrishnan	gopalakrishnan	PROPN
dti-1378	513	2	k	k	NOUN
dti-1378	513	3	,	,	PUNCT
dti-1378	513	4	sowmiya	sowmiya	NOUN
dti-1378	513	5	g	g	PROPN
dti-1378	513	6	,	,	PUNCT
dti-1378	513	7	sheik	sheik	PROPN
dti-1378	513	8	ss	ss	PROPN
dti-1378	513	9	,	,	PUNCT
dti-1378	513	10	sekar	sekar	PROPN
dti-1378	513	11	k.	k.	PROPN
dti-1378	513	12	ramachandran	ramachandran	PROPN
dti-1378	513	13	plot	plot	PROPN
dti-1378	513	14	on	on	ADP
dti-1378	513	15	the	the	DET
dti-1378	513	16	web	web	NOUN
dti-1378	513	17	(	(	PUNCT
dti-1378	513	18	2.0	2.0	NUM
dti-1378	513	19	)	)	PUNCT
dti-1378	513	20	.	.	PUNCT
dti-1378	514	1	protein	protein	NOUN
dti-1378	514	2	peptide	peptide	VERB
dti-1378	514	3	lett	lett	PROPN
dti-1378	514	4	.	.	PUNCT
dti-1378	515	1	2007;14(7):669–71	2007;14(7):669–71	NUM
dti-1378	515	2	.	.	PUNCT
dti-1378	516	1	27	27	NUM
dti-1378	516	2	.	.	PUNCT
dti-1378	517	1	lovell	lovell	PROPN
dti-1378	517	2	sc	sc	PROPN
dti-1378	517	3	,	,	PUNCT
dti-1378	517	4	davis	davis	PROPN
dti-1378	517	5	iw	iw	PROPN
dti-1378	517	6	,	,	PUNCT
dti-1378	517	7	arendall	arendall	NOUN
dti-1378	517	8	wb	wb	PROPN
dti-1378	517	9	3rd	3rd	NOUN
dti-1378	517	10	,	,	PUNCT
dti-1378	517	11	et	et	PROPN
dti-1378	517	12	al	al	PROPN
dti-1378	517	13	.	.	PUNCT
dti-1378	517	14	structure	structure	NOUN
dti-1378	517	15	validation	validation	NOUN
dti-1378	517	16	by	by	ADP
dti-1378	517	17	calpha	calpha	PROPN
dti-1378	517	18	geometry	geometry	NOUN
dti-1378	517	19	:	:	PUNCT
dti-1378	517	20	phi	phi	NOUN
dti-1378	517	21	,	,	PUNCT
dti-1378	517	22	psi	psi	NOUN
dti-1378	517	23	and	and	CCONJ
dti-1378	517	24	cbeta	cbeta	NOUN
dti-1378	517	25	deviation	deviation	NOUN
dti-1378	517	26	.	.	PUNCT
dti-1378	518	1	proteins	protein	NOUN
dti-1378	518	2	.	.	PUNCT
dti-1378	519	1	2003;50(3):437–50	2003;50(3):437–50	NUM
dti-1378	519	2	.	.	PUNCT
dti-1378	520	1	28	28	NUM
dti-1378	520	2	.	.	PROPN
dti-1378	520	3	hooft	hooft	PROPN
dti-1378	520	4	rw	rw	PROPN
dti-1378	520	5	,	,	PUNCT
dti-1378	520	6	sander	sander	PROPN
dti-1378	520	7	c	c	PROPN
dti-1378	520	8	,	,	PUNCT
dti-1378	520	9	vriend	vriend	PROPN
dti-1378	520	10	g.	g.	PROPN
dti-1378	520	11	objectively	objectively	ADV
dti-1378	520	12	judging	judge	VERB
dti-1378	520	13	the	the	DET
dti-1378	520	14	quality	quality	NOUN
dti-1378	520	15	of	of	ADP
dti-1378	520	16	a	a	DET
dti-1378	520	17	protein	protein	NOUN
dti-1378	520	18	structure	structure	NOUN
dti-1378	520	19	from	from	ADP
dti-1378	520	20	a	a	DET
dti-1378	520	21	ramachandran	ramachandran	PROPN
dti-1378	520	22	plot	plot	NOUN
dti-1378	520	23	.	.	PUNCT
dti-1378	521	1	comput	comput	PROPN
dti-1378	521	2	appl	appl	PROPN
dti-1378	521	3	biosci	biosci	PROPN
dti-1378	521	4	.	.	PUNCT
dti-1378	522	1	1997;13(4	1997;13(4	NUM
dti-1378	522	2	):	):	PUNCT
dti-1378	522	3	425–30	425–30	PROPN
dti-1378	522	4	.	.	PROPN
dti-1378	522	5	29	29	NUM
dti-1378	522	6	.	.	PUNCT
dti-1378	523	1	porter	porter	PROPN
dti-1378	523	2	ll	ll	PROPN
dti-1378	523	3	,	,	PUNCT
dti-1378	523	4	rose	rise	VERB
dti-1378	523	5	gd	gd	NOUN
dti-1378	523	6	.	.	PUNCT
dti-1378	523	7	redrawing	redrawe	VERB
dti-1378	523	8	the	the	DET
dti-1378	523	9	ramachandran	ramachandran	PROPN
dti-1378	523	10	plot	plot	NOUN
dti-1378	523	11	after	after	ADP
dti-1378	523	12	inclusion	inclusion	NOUN
dti-1378	523	13	of	of	ADP
dti-1378	523	14	hydrogen	hydrogen	NOUN
dti-1378	523	15	-	-	PUNCT
dti-1378	523	16	bonding	bonding	NOUN
dti-1378	523	17	constraints	constraint	NOUN
dti-1378	523	18	.	.	PUNCT
dti-1378	524	1	proc	proc	PROPN
dti-1378	524	2	natl	natl	PROPN
dti-1378	524	3	acad	acad	PROPN
dti-1378	524	4	sci	sci	PROPN
dti-1378	524	5	u	u	PROPN
dti-1378	524	6	s	s	NOUN
dti-1378	524	7	a.	a.	NOUN
dti-1378	524	8	2011;108(1):109–13	2011;108(1):109–13	NUM
dti-1378	524	9	.	.	PROPN
dti-1378	524	10	30	30	NUM
dti-1378	524	11	.	.	PUNCT
dti-1378	525	1	zhou	zhou	PROPN
dti-1378	525	2	aq	aq	PROPN
dti-1378	525	3	,	,	PUNCT
dti-1378	525	4	o’hern	o’hern	ADJ
dti-1378	525	5	cs	cs	PROPN
dti-1378	525	6	,	,	PUNCT
dti-1378	525	7	regan	regan	PROPN
dti-1378	525	8	l.	l.	PROPN
dti-1378	525	9	revisiting	revisit	VERB
dti-1378	525	10	the	the	DET
dti-1378	525	11	ramachandran	ramachandran	PROPN
dti-1378	525	12	plot	plot	NOUN
dti-1378	525	13	from	from	ADP
dti-1378	525	14	a	a	DET
dti-1378	525	15	new	new	ADJ
dti-1378	525	16	angle	angle	NOUN
dti-1378	525	17	.	.	PUNCT
dti-1378	526	1	protein	protein	NOUN
dti-1378	526	2	sci	sci	PROPN
dti-1378	526	3	.	.	PUNCT
dti-1378	527	1	2011;20(7):1166–71	2011;20(7):1166–71	PROPN
dti-1378	527	2	.	.	PUNCT
dti-1378	528	1	31	31	NUM
dti-1378	528	2	.	.	PUNCT
dti-1378	529	1	maccallum	maccallum	PROPN
dti-1378	529	2	ph	ph	PROPN
dti-1378	529	3	,	,	PUNCT
dti-1378	529	4	poet	poet	NOUN
dti-1378	529	5	r	r	NOUN
dti-1378	529	6	,	,	PUNCT
dti-1378	529	7	milner	milner	NOUN
dti-1378	529	8	-	-	PUNCT
dti-1378	529	9	white	white	ADJ
dti-1378	529	10	ej	ej	PROPN
dti-1378	529	11	.	.	PROPN
dti-1378	529	12	coulombic	coulombic	ADJ
dti-1378	529	13	attractions	attraction	NOUN
dti-1378	529	14	between	between	ADP
dti-1378	529	15	partially	partially	ADV
dti-1378	529	16	charged	charge	VERB
dti-1378	529	17	main	main	ADJ
dti-1378	529	18	-	-	PUNCT
dti-1378	529	19	chain	chain	NOUN
dti-1378	529	20	atoms	atom	NOUN
dti-1378	529	21	stabilise	stabilise	VERB
dti-1378	529	22	the	the	DET
dti-1378	529	23	right	right	ADV
dti-1378	529	24	-	-	PUNCT
dti-1378	529	25	handed	handed	ADJ
dti-1378	529	26	twist	twist	NOUN
dti-1378	529	27	found	find	VERB
dti-1378	529	28	in	in	ADP
dti-1378	529	29	most	most	ADJ
dti-1378	529	30	beta	beta	NOUN
dti-1378	529	31	-	-	PUNCT
dti-1378	529	32	strands	strand	NOUN
dti-1378	529	33	.	.	PUNCT
dti-1378	530	1	j	j	PROPN
dti-1378	530	2	mol	mol	ADP
dti-1378	530	3	biol	biol	PROPN
dti-1378	530	4	.	.	PUNCT
dti-1378	531	1	1995;248(2):374–84	1995;248(2):374–84	NOUN
dti-1378	531	2	.	.	PUNCT
dti-1378	532	1	32	32	NUM
dti-1378	532	2	.	.	PUNCT
dti-1378	533	1	brändeén	brändeén	PROPN
dti-1378	533	2	ci	ci	PROPN
dti-1378	533	3	.	.	PROPN
dti-1378	533	4	relation	relation	NOUN
dti-1378	533	5	between	between	ADP
dti-1378	533	6	structure	structure	NOUN
dti-1378	533	7	and	and	CCONJ
dti-1378	533	8	function	function	NOUN
dti-1378	533	9	of	of	ADP
dti-1378	533	10	alpha	alpha	NOUN
dti-1378	533	11	/	/	SYM
dti-1378	533	12	beta	beta	NOUN
dti-1378	533	13	-	-	PUNCT
dti-1378	533	14	proteins	protein	NOUN
dti-1378	533	15	.	.	PUNCT
dti-1378	534	1	q	q	PROPN
dti-1378	534	2	rev	rev	PROPN
dti-1378	534	3	biophys	biophy	NOUN
dti-1378	534	4	.	.	PUNCT
dti-1378	535	1	1980;13(3):317–38	1980;13(3):317–38	NUM
dti-1378	535	2	.	.	PUNCT
dti-1378	536	1	33	33	NUM
dti-1378	536	2	.	.	PUNCT
dti-1378	537	1	jurnak	jurnak	PROPN
dti-1378	537	2	f	f	PROPN
dti-1378	537	3	,	,	PUNCT
dti-1378	537	4	mcpherson	mcpherson	PROPN
dti-1378	537	5	a	a	PROPN
dti-1378	537	6	,	,	PUNCT
dti-1378	537	7	wang	wang	PROPN
dti-1378	537	8	ah	ah	INTJ
dti-1378	537	9	,	,	PUNCT
dti-1378	537	10	rich	rich	ADJ
dti-1378	537	11	a.	a.	NOUN
dti-1378	537	12	biochemical	biochemical	ADJ
dti-1378	537	13	and	and	CCONJ
dti-1378	537	14	structural	structural	ADJ
dti-1378	537	15	studies	study	NOUN
dti-1378	537	16	of	of	ADP
dti-1378	537	17	the	the	DET
dti-1378	537	18	tetragonal	tetragonal	ADJ
dti-1378	537	19	crystalline	crystalline	NOUN
dti-1378	537	20	modification	modification	NOUN
dti-1378	537	21	of	of	ADP
dti-1378	537	22	the	the	DET
dti-1378	537	23	escherichia	escherichia	NOUN
dti-1378	537	24	coli	coli	NOUN
dti-1378	537	25	elongation	elongation	NOUN
dti-1378	537	26	factor	factor	NOUN
dti-1378	537	27	tu	tu	PROPN
dti-1378	537	28	.	.	PROPN
dti-1378	538	1	j	j	PROPN
dti-1378	538	2	biol	biol	PROPN
dti-1378	538	3	chem	chem	NOUN
dti-1378	538	4	.	.	PUNCT
dti-1378	539	1	1980;255(14):6751–7	1980;255(14):6751–7	NUM
dti-1378	539	2	.	.	PROPN
dti-1378	540	1	34	34	NUM
dti-1378	540	2	.	.	PUNCT
dti-1378	540	3	colicelli	colicelli	PROPN
dti-1378	540	4	j.	j.	PROPN
dti-1378	540	5	signal	signal	PROPN
dti-1378	540	6	transduction	transduction	NOUN
dti-1378	540	7	:	:	PUNCT
dti-1378	540	8	rabgef1	rabgef1	NOUN
dti-1378	540	9	fingers	finger	NOUN
dti-1378	540	10	ras	ra	VERB
dti-1378	540	11	for	for	ADP
dti-1378	540	12	ubiquitination	ubiquitination	NOUN
dti-1378	540	13	.	.	PUNCT
dti-1378	541	1	curr	curr	PROPN
dti-1378	541	2	biol	biol	PROPN
dti-1378	541	3	.	.	PUNCT
dti-1378	542	1	2010;20(15):r630–2	2010;20(15):r630–2	NUM
dti-1378	542	2	.	.	PUNCT
dti-1378	542	3	35	35	NUM
dti-1378	542	4	.	.	PUNCT
dti-1378	542	5	field	field	PROPN
dti-1378	542	6	cm	cm	PROPN
dti-1378	542	7	,	,	PUNCT
dti-1378	542	8	kellogg	kellogg	PROPN
dti-1378	542	9	d.	d.	PROPN
dti-1378	542	10	septins	septin	VERB
dti-1378	542	11	:	:	PUNCT
dti-1378	542	12	cytoskeletal	cytoskeletal	ADJ
dti-1378	542	13	polymers	polymer	NOUN
dti-1378	542	14	or	or	CCONJ
dti-1378	542	15	signalling	signal	VERB
dti-1378	542	16	gtpases	gtpase	NOUN
dti-1378	542	17	?	?	PUNCT
dti-1378	543	1	trends	trend	NOUN
dti-1378	543	2	cell	cell	NOUN
dti-1378	543	3	biol	biol	NOUN
dti-1378	543	4	.	.	PUNCT
dti-1378	544	1	1999;9(10):387–94	1999;9(10):387–94	X
dti-1378	544	2	.	.	PUNCT
dti-1378	545	1	36	36	NUM
dti-1378	545	2	.	.	PUNCT
dti-1378	546	1	pandit	pandit	PROPN
dti-1378	546	2	sb	sb	PROPN
dti-1378	546	3	,	,	PUNCT
dti-1378	546	4	srinivasan	srinivasan	PROPN
dti-1378	546	5	n.	n.	PROPN
dti-1378	546	6	survey	survey	NOUN
dti-1378	546	7	for	for	ADP
dti-1378	546	8	g	g	NOUN
dti-1378	546	9	-	-	PUNCT
dti-1378	546	10	proteins	protein	NOUN
dti-1378	546	11	in	in	ADP
dti-1378	546	12	the	the	DET
dti-1378	546	13	prokaryotic	prokaryotic	ADJ
dti-1378	546	14	genomes	genome	NOUN
dti-1378	546	15	:	:	PUNCT
dti-1378	546	16	prediction	prediction	NOUN
dti-1378	546	17	of	of	ADP
dti-1378	546	18	functional	functional	ADJ
dti-1378	546	19	roles	role	NOUN
dti-1378	546	20	based	base	VERB
dti-1378	546	21	on	on	ADP
dti-1378	546	22	classification	classification	NOUN
dti-1378	546	23	.	.	PUNCT
dti-1378	547	1	proteins	protein	NOUN
dti-1378	547	2	.	.	PUNCT
dti-1378	548	1	2003;52(4):585–97	2003;52(4):585–97	NUM
dti-1378	548	2	.	.	PUNCT
dti-1378	549	1	37	37	NUM
dti-1378	549	2	.	.	PUNCT
dti-1378	550	1	walker	walker	PROPN
dti-1378	550	2	je	je	PROPN
dti-1378	550	3	,	,	PUNCT
dti-1378	550	4	runswick	runswick	PROPN
dti-1378	550	5	mj	mj	PROPN
dti-1378	550	6	,	,	PUNCT
dti-1378	550	7	saraste	saraste	ADJ
dti-1378	550	8	m.	m.	NOUN
dti-1378	550	9	subunit	subunit	NOUN
dti-1378	550	10	equivalence	equivalence	NOUN
dti-1378	550	11	in	in	ADP
dti-1378	550	12	escherichia	escherichia	NOUN
dti-1378	550	13	coli	coli	NOUN
dti-1378	550	14	and	and	CCONJ
dti-1378	550	15	bovine	bovine	NOUN
dti-1378	550	16	heart	heart	NOUN
dti-1378	550	17	mitochondrial	mitochondrial	ADJ
dti-1378	550	18	f1f0	f1f0	ADP
dti-1378	550	19	atpases	atpase	NOUN
dti-1378	550	20	.	.	PUNCT
dti-1378	551	1	febs	febs	PROPN
dti-1378	551	2	lett	lett	PROPN
dti-1378	551	3	.	.	PUNCT
dti-1378	552	1	1982;146(2):393–6	1982;146(2):393–6	NUM
dti-1378	552	2	.	.	PUNCT
dti-1378	553	1	38	38	NUM
dti-1378	553	2	.	.	PUNCT
dti-1378	554	1	berezovsky	berezovsky	NOUN
dti-1378	554	2	in	in	ADP
dti-1378	554	3	,	,	PUNCT
dti-1378	554	4	trifonov	trifonov	ADP
dti-1378	554	5	en	en	PROPN
dti-1378	554	6	.	.	PUNCT
dti-1378	555	1	van	van	PROPN
dti-1378	555	2	der	der	PROPN
dti-1378	555	3	waals	waal	NOUN
dti-1378	555	4	locks	lock	NOUN
dti-1378	555	5	:	:	PUNCT
dti-1378	555	6	loop	loop	NOUN
dti-1378	555	7	-	-	PUNCT
dti-1378	555	8	n	n	CCONJ
dti-1378	555	9	-	-	PUNCT
dti-1378	555	10	lock	lock	NOUN
dti-1378	555	11	structure	structure	NOUN
dti-1378	555	12	of	of	ADP
dti-1378	555	13	globular	globular	ADJ
dti-1378	555	14	proteins	protein	NOUN
dti-1378	555	15	.	.	PUNCT
dti-1378	556	1	j	j	PROPN
dti-1378	556	2	mol	mol	ADP
dti-1378	556	3	biol	biol	PROPN
dti-1378	556	4	.	.	PUNCT
dti-1378	557	1	2001;307(5):1419–26	2001;307(5):1419–26	X
dti-1378	557	2	.	.	NOUN
dti-1378	557	3	39	39	NUM
dti-1378	557	4	.	.	PUNCT
dti-1378	558	1	sillero	sillero	PROPN
dti-1378	558	2	a	a	PRON
dti-1378	558	3	,	,	PUNCT
dti-1378	558	4	maldonado	maldonado	PROPN
dti-1378	558	5	a.	a.	PROPN
dti-1378	558	6	isoelectric	isoelectric	PROPN
dti-1378	558	7	point	point	VERB
dti-1378	558	8	determination	determination	NOUN
dti-1378	558	9	of	of	ADP
dti-1378	558	10	proteins	protein	NOUN
dti-1378	558	11	and	and	CCONJ
dti-1378	558	12	other	other	ADJ
dti-1378	558	13	macromolecules	macromolecule	NOUN
dti-1378	558	14	:	:	PUNCT
dti-1378	558	15	oscillating	oscillate	VERB
dti-1378	558	16	method	method	NOUN
dti-1378	558	17	.	.	PUNCT
dti-1378	559	1	comput	comput	PROPN
dti-1378	559	2	biol	biol	PROPN
dti-1378	559	3	med	me	VERB
dti-1378	559	4	.	.	PUNCT
dti-1378	560	1	2006;36(2	2006;36(2	NUM
dti-1378	560	2	):	):	PUNCT
dti-1378	560	3	157–66	157–66	NUM
dti-1378	560	4	.	.	PROPN
dti-1378	561	1	40	40	NUM
dti-1378	561	2	.	.	PUNCT
dti-1378	562	1	stoscheck	stoscheck	PROPN
dti-1378	562	2	cm	cm	PROPN
dti-1378	562	3	.	.	PUNCT
dti-1378	563	1	quantitation	quantitation	NOUN
dti-1378	563	2	of	of	ADP
dti-1378	563	3	protein	protein	NOUN
dti-1378	563	4	.	.	PUNCT
dti-1378	564	1	methods	method	NOUN
dti-1378	564	2	enzymol	enzymol	PROPN
dti-1378	564	3	.	.	PUNCT
dti-1378	565	1	1990;182	1990;182	NUM
dti-1378	565	2	:	:	PUNCT
dti-1378	566	1	50–68	50–68	NUM
dti-1378	566	2	.	.	PUNCT
dti-1378	566	3	41	41	NUM
dti-1378	566	4	.	.	PUNCT
dti-1378	567	1	gill	gill	PROPN
dti-1378	567	2	sc	sc	PROPN
dti-1378	567	3	,	,	PUNCT
dti-1378	567	4	von	von	PROPN
dti-1378	567	5	hippel	hippel	PROPN
dti-1378	567	6	ph	ph	PROPN
dti-1378	567	7	.	.	PROPN
dti-1378	567	8	calculation	calculation	NOUN
dti-1378	567	9	of	of	ADP
dti-1378	567	10	protein	protein	NOUN
dti-1378	567	11	extinction	extinction	NOUN
dti-1378	567	12	coefficients	coefficient	NOUN
dti-1378	567	13	from	from	ADP
dti-1378	567	14	amino	amino	NOUN
dti-1378	567	15	acid	acid	NOUN
dti-1378	567	16	sequence	sequence	NOUN
dti-1378	567	17	data	datum	NOUN
dti-1378	567	18	.	.	PUNCT
dti-1378	568	1	anal	anal	ADJ
dti-1378	568	2	biochem	biochem	PROPN
dti-1378	568	3	.	.	PUNCT
dti-1378	569	1	1989;182(2):319–26	1989;182(2):319–26	NUM
dti-1378	569	2	.	.	PUNCT
dti-1378	570	1	42	42	NUM
dti-1378	570	2	.	.	PUNCT
dti-1378	570	3	bachmair	bachmair	PROPN
dti-1378	570	4	a	a	PRON
dti-1378	570	5	,	,	PUNCT
dti-1378	570	6	finley	finley	PROPN
dti-1378	570	7	d	d	PROPN
dti-1378	570	8	,	,	PUNCT
dti-1378	570	9	varshavsky	varshavsky	NOUN
dti-1378	570	10	a.	a.	NOUN
dti-1378	570	11	in	in	ADP
dti-1378	570	12	vivo	vivo	ADJ
dti-1378	570	13	half	half	ADJ
dti-1378	570	14	-	-	PUNCT
dti-1378	570	15	life	life	NOUN
dti-1378	570	16	of	of	ADP
dti-1378	570	17	a	a	DET
dti-1378	570	18	protein	protein	NOUN
dti-1378	570	19	is	be	AUX
dti-1378	570	20	a	a	DET
dti-1378	570	21	function	function	NOUN
dti-1378	570	22	of	of	ADP
dti-1378	570	23	its	its	PRON
dti-1378	570	24	amino	amino	NOUN
dti-1378	570	25	-	-	PUNCT
dti-1378	570	26	terminal	terminal	ADJ
dti-1378	570	27	residue	residue	NOUN
dti-1378	570	28	.	.	PUNCT
dti-1378	571	1	science	science	NOUN
dti-1378	571	2	.	.	PUNCT
dti-1378	572	1	1986;234(4773):179–86	1986;234(4773):179–86	NUM
dti-1378	572	2	.	.	PUNCT
dti-1378	573	1	43	43	NUM
dti-1378	573	2	.	.	PUNCT
dti-1378	574	1	gonda	gonda	PROPN
dti-1378	574	2	dk	dk	PROPN
dti-1378	574	3	,	,	PUNCT
dti-1378	574	4	bachmair	bachmair	VERB
dti-1378	574	5	a	a	ADV
dti-1378	574	6	,	,	PUNCT
dti-1378	574	7	wünning	wünne	VERB
dti-1378	574	8	i	i	PRON
dti-1378	574	9	,	,	PUNCT
dti-1378	574	10	tobias	tobias	PROPN
dti-1378	574	11	jw	jw	PROPN
dti-1378	574	12	,	,	PUNCT
dti-1378	574	13	lane	lane	PROPN
dti-1378	574	14	ws	ws	PROPN
dti-1378	574	15	,	,	PUNCT
dti-1378	574	16	varshavsky	varshavsky	NOUN
dti-1378	574	17	a.	a.	NOUN
dti-1378	574	18	universality	universality	NOUN
dti-1378	574	19	and	and	CCONJ
dti-1378	574	20	structure	structure	NOUN
dti-1378	574	21	of	of	ADP
dti-1378	574	22	the	the	DET
dti-1378	574	23	n	n	NUM
dti-1378	574	24	-	-	PUNCT
dti-1378	574	25	end	end	NOUN
dti-1378	574	26	rule	rule	NOUN
dti-1378	574	27	.	.	PUNCT
dti-1378	575	1	j	j	PROPN
dti-1378	575	2	biol	biol	PROPN
dti-1378	575	3	chem	chem	NOUN
dti-1378	575	4	.	.	PUNCT
dti-1378	576	1	1989;264(28	1989;264(28	NUM
dti-1378	576	2	):	):	PUNCT
dti-1378	577	1	16700–12	16700–12	NOUN
dti-1378	577	2	.	.	PUNCT
dti-1378	578	1	44	44	NUM
dti-1378	578	2	.	.	PUNCT
dti-1378	578	3	varshavsky	varshavsky	PROPN
dti-1378	578	4	a.	a.	NOUN
dti-1378	578	5	the	the	DET
dti-1378	578	6	n	n	NUM
dti-1378	578	7	-	-	PUNCT
dti-1378	578	8	end	end	NOUN
dti-1378	578	9	rule	rule	NOUN
dti-1378	578	10	pathway	pathway	NOUN
dti-1378	578	11	of	of	ADP
dti-1378	578	12	protein	protein	NOUN
dti-1378	578	13	degradation	degradation	NOUN
dti-1378	578	14	.	.	PUNCT
dti-1378	579	1	genes	gene	NOUN
dti-1378	579	2	cells	cell	NOUN
dti-1378	579	3	.	.	PUNCT
dti-1378	580	1	1997;2(1):13–28	1997;2(1):13–28	NUM
dti-1378	580	2	.	.	PUNCT
dti-1378	581	1	45	45	NUM
dti-1378	581	2	.	.	PUNCT
dti-1378	581	3	guruprasad	guruprasad	PROPN
dti-1378	581	4	k	k	PROPN
dti-1378	581	5	,	,	PUNCT
dti-1378	581	6	reddy	reddy	PROPN
dti-1378	581	7	bv	bv	PROPN
dti-1378	581	8	,	,	PUNCT
dti-1378	581	9	pandit	pandit	PROPN
dti-1378	581	10	mw	mw	PROPN
dti-1378	581	11	.	.	PROPN
dti-1378	581	12	correlation	correlation	NOUN
dti-1378	581	13	between	between	ADP
dti-1378	581	14	stability	stability	NOUN
dti-1378	581	15	of	of	ADP
dti-1378	581	16	a	a	DET
dti-1378	581	17	protein	protein	NOUN
dti-1378	581	18	and	and	CCONJ
dti-1378	581	19	its	its	PRON
dti-1378	581	20	dipeptide	dipeptide	NOUN
dti-1378	581	21	composition	composition	NOUN
dti-1378	581	22	:	:	PUNCT
dti-1378	581	23	a	a	DET
dti-1378	581	24	novel	novel	ADJ
dti-1378	581	25	approach	approach	NOUN
dti-1378	581	26	for	for	ADP
dti-1378	581	27	predicting	predict	VERB
dti-1378	581	28	in	in	ADP
dti-1378	581	29	vivo	vivo	ADJ
dti-1378	581	30	stability	stability	NOUN
dti-1378	581	31	of	of	ADP
dti-1378	581	32	a	a	DET
dti-1378	581	33	protein	protein	NOUN
dti-1378	581	34	from	from	ADP
dti-1378	581	35	its	its	PRON
dti-1378	581	36	primary	primary	ADJ
dti-1378	581	37	sequence	sequence	NOUN
dti-1378	581	38	.	.	PUNCT
dti-1378	582	1	protein	protein	NOUN
dti-1378	582	2	eng	eng	PROPN
dti-1378	582	3	.	.	PUNCT
dti-1378	583	1	1990;4(2):155–61	1990;4(2):155–61	NUM
dti-1378	583	2	.	.	PROPN
dti-1378	583	3	46	46	NUM
dti-1378	583	4	.	.	PUNCT
dti-1378	584	1	chen	chen	PROPN
dti-1378	584	2	yw	yw	PROPN
dti-1378	584	3	,	,	PUNCT
dti-1378	584	4	fersht	fersht	PROPN
dti-1378	584	5	ar	ar	PROPN
dti-1378	584	6	,	,	PUNCT
dti-1378	584	7	henrick	henrick	PROPN
dti-1378	584	8	k.	k.	PROPN
dti-1378	584	9	contribution	contribution	PROPN
dti-1378	584	10	of	of	ADP
dti-1378	584	11	buried	bury	VERB
dti-1378	584	12	hydrogen	hydrogen	NOUN
dti-1378	584	13	bonds	bond	NOUN
dti-1378	584	14	to	to	ADP
dti-1378	584	15	protein	protein	NOUN
dti-1378	584	16	stability	stability	NOUN
dti-1378	584	17	.	.	PUNCT
dti-1378	585	1	the	the	DET
dti-1378	585	2	crystal	crystal	NOUN
dti-1378	585	3	structures	structure	NOUN
dti-1378	585	4	of	of	ADP
dti-1378	585	5	two	two	NUM
dti-1378	585	6	barnase	barnase	NOUN
dti-1378	585	7	mutants	mutant	NOUN
dti-1378	585	8	.	.	PUNCT
dti-1378	586	1	j	j	PROPN
dti-1378	586	2	mol	mol	ADP
dti-1378	586	3	biol	biol	PROPN
dti-1378	586	4	.	.	PUNCT
dti-1378	587	1	1993;234(4):1158–70	1993;234(4):1158–70	NUM
dti-1378	587	2	.	.	PUNCT
dti-1378	588	1	47	47	NUM
dti-1378	588	2	.	.	PUNCT
dti-1378	588	3	ikai	ikai	PROPN
dti-1378	588	4	a.	a.	PROPN
dti-1378	588	5	thermostability	thermostability	PROPN
dti-1378	588	6	and	and	CCONJ
dti-1378	588	7	aliphatic	aliphatic	ADJ
dti-1378	588	8	index	index	NOUN
dti-1378	588	9	of	of	ADP
dti-1378	588	10	globular	globular	ADJ
dti-1378	588	11	proteins	protein	NOUN
dti-1378	588	12	.	.	PUNCT
dti-1378	589	1	j	j	PROPN
dti-1378	589	2	biochem	biochem	PROPN
dti-1378	589	3	.	.	PUNCT
dti-1378	590	1	1980;88(6):1895–8	1980;88(6):1895–8	X
dti-1378	590	2	.	.	PROPN
dti-1378	590	3	48	48	NUM
dti-1378	590	4	.	.	PUNCT
dti-1378	591	1	kyte	kyte	PROPN
dti-1378	591	2	j	j	PROPN
dti-1378	591	3	,	,	PUNCT
dti-1378	591	4	doolittle	doolittle	PROPN
dti-1378	591	5	rf	rf	PROPN
dti-1378	591	6	.	.	PUNCT
dti-1378	592	1	a	a	DET
dti-1378	592	2	simple	simple	ADJ
dti-1378	592	3	method	method	NOUN
dti-1378	592	4	for	for	ADP
dti-1378	592	5	displaying	display	VERB
dti-1378	592	6	the	the	DET
dti-1378	592	7	hydropathic	hydropathic	ADJ
dti-1378	592	8	character	character	NOUN
dti-1378	592	9	of	of	ADP
dti-1378	592	10	a	a	DET
dti-1378	592	11	protein	protein	NOUN
dti-1378	592	12	.	.	PUNCT
dti-1378	593	1	j	j	PROPN
dti-1378	593	2	mol	mol	ADP
dti-1378	593	3	biol	biol	PROPN
dti-1378	593	4	.	.	PUNCT
dti-1378	594	1	1982;157(1):105–32	1982;157(1):105–32	NUM
dti-1378	594	2	.	.	PUNCT
dti-1378	595	1	49	49	NUM
dti-1378	595	2	.	.	PUNCT
dti-1378	596	1	hopp	hopp	PROPN
dti-1378	596	2	tp	tp	PROPN
dti-1378	596	3	,	,	PUNCT
dti-1378	596	4	woods	woods	PROPN
dti-1378	596	5	kr	kr	PROPN
dti-1378	596	6	.	.	PROPN
dti-1378	596	7	prediction	prediction	NOUN
dti-1378	596	8	of	of	ADP
dti-1378	596	9	protein	protein	NOUN
dti-1378	596	10	antigenic	antigenic	ADJ
dti-1378	596	11	determinants	determinant	NOUN
dti-1378	596	12	from	from	ADP
dti-1378	596	13	amino	amino	NOUN
dti-1378	596	14	acid	acid	NOUN
dti-1378	596	15	sequences	sequence	NOUN
dti-1378	596	16	.	.	PUNCT
dti-1378	597	1	proc	proc	PROPN
dti-1378	597	2	natl	natl	PROPN
dti-1378	597	3	acad	acad	PROPN
dti-1378	597	4	sci	sci	PROPN
dti-1378	597	5	u	u	PROPN
dti-1378	597	6	s	s	NOUN
dti-1378	597	7	a.	a.	NOUN
dti-1378	597	8	1981;78(6):3824–8	1981;78(6):3824–8	NUM
dti-1378	597	9	.	.	PROPN
dti-1378	597	10	50	50	NUM
dti-1378	597	11	.	.	PUNCT
dti-1378	598	1	colicelli	colicelli	PROPN
dti-1378	598	2	j.	j.	PROPN
dti-1378	598	3	human	human	PROPN
dti-1378	598	4	ras	ras	PROPN
dti-1378	598	5	superfamily	superfamily	ADJ
dti-1378	598	6	proteins	protein	NOUN
dti-1378	598	7	and	and	CCONJ
dti-1378	598	8	related	related	ADJ
dti-1378	598	9	gtpases	gtpase	NOUN
dti-1378	598	10	.	.	PUNCT
dti-1378	599	1	sci	sci	PROPN
dti-1378	599	2	stke	stke	NOUN
dti-1378	599	3	.	.	PUNCT
dti-1378	600	1	2004;2004(250):re13	2004;2004(250):re13	NUM
dti-1378	600	2	.	.	X
dti-1378	601	1	51	51	NUM
dti-1378	601	2	.	.	PUNCT
dti-1378	601	3	yamanaka	yamanaka	PROPN
dti-1378	601	4	g	g	PROPN
dti-1378	601	5	,	,	PUNCT
dti-1378	601	6	eckstein	eckstein	PROPN
dti-1378	601	7	f	f	PROPN
dti-1378	601	8	,	,	PUNCT
dti-1378	601	9	stryer	stryer	NOUN
dti-1378	601	10	l.	l.	PROPN
dti-1378	601	11	interaction	interaction	NOUN
dti-1378	601	12	of	of	ADP
dti-1378	601	13	retinal	retinal	ADJ
dti-1378	601	14	transducin	transducin	PROPN
dti-1378	601	15	with	with	ADP
dti-1378	601	16	guanosine	guanosine	NOUN
dti-1378	601	17	triphosphate	triphosphate	NOUN
dti-1378	601	18	analogues	analogue	NOUN
dti-1378	601	19	:	:	PUNCT
dti-1378	601	20	specificity	specificity	NOUN
dti-1378	601	21	of	of	ADP
dti-1378	601	22	the	the	DET
dti-1378	601	23	gamma	gamma	NOUN
dti-1378	601	24	-	-	PUNCT
dti-1378	601	25	phosphate	phosphate	ADJ
dti-1378	601	26	binding	bind	VERB
dti-1378	601	27	region	region	NOUN
dti-1378	601	28	.	.	PUNCT
dti-1378	602	1	biochemistry	biochemistry	NOUN
dti-1378	602	2	.	.	PUNCT
dti-1378	603	1	1986;25(20):6149–53	1986;25(20):6149–53	NUM
dti-1378	603	2	.	.	PUNCT
dti-1378	604	1	52	52	NUM
dti-1378	604	2	.	.	PUNCT
dti-1378	605	1	gilman	gilman	PROPN
dti-1378	605	2	ag	ag	PROPN
dti-1378	605	3	.	.	PUNCT
dti-1378	606	1	g	g	PROPN
dti-1378	606	2	proteins	protein	NOUN
dti-1378	606	3	:	:	PUNCT
dti-1378	606	4	transducers	transducer	NOUN
dti-1378	606	5	of	of	ADP
dti-1378	606	6	receptor	receptor	NOUN
dti-1378	606	7	-	-	PUNCT
dti-1378	606	8	generated	generate	VERB
dti-1378	606	9	signals	signal	NOUN
dti-1378	606	10	.	.	PUNCT
dti-1378	607	1	annu	annu	PROPN
dti-1378	607	2	rev	rev	VERB
dti-1378	607	3	biochem	biochem	PROPN
dti-1378	607	4	.	.	PUNCT
dti-1378	608	1	1987;56:615–49	1987;56:615–49	NUM
dti-1378	608	2	.	.	PUNCT
dti-1378	609	1	53	53	NUM
dti-1378	609	2	.	.	PUNCT
dti-1378	609	3	birnbaumer	birnbaumer	PROPN
dti-1378	609	4	l.	l.	PROPN
dti-1378	609	5	transduction	transduction	NOUN
dti-1378	609	6	of	of	ADP
dti-1378	609	7	receptor	receptor	NOUN
dti-1378	609	8	signal	signal	NOUN
dti-1378	609	9	into	into	ADP
dti-1378	609	10	modulation	modulation	NOUN
dti-1378	609	11	of	of	ADP
dti-1378	609	12	effector	effector	NOUN
dti-1378	609	13	activity	activity	NOUN
dti-1378	609	14	by	by	ADP
dti-1378	609	15	g	g	PROPN
dti-1378	609	16	proteins	protein	NOUN
dti-1378	609	17	:	:	PUNCT
dti-1378	609	18	the	the	DET
dti-1378	609	19	first	first	ADJ
dti-1378	609	20	20	20	NUM
dti-1378	609	21	years	year	NOUN
dti-1378	609	22	or	or	CCONJ
dti-1378	609	23	so	so	ADV
dti-1378	609	24	…	…	PUNCT
dti-1378	609	25	faseb	faseb	PROPN
dti-1378	609	26	j.	j.	PROPN
dti-1378	609	27	1990;4(14	1990;4(14	PROPN
dti-1378	609	28	):	):	PUNCT
dti-1378	609	29	3178–88	3178–88	NUM
dti-1378	609	30	.	.	PUNCT
dti-1378	610	1	54	54	NUM
dti-1378	610	2	.	.	PUNCT
dti-1378	611	1	higashijima	higashijima	PROPN
dti-1378	611	2	t	t	PROPN
dti-1378	611	3	,	,	PUNCT
dti-1378	611	4	ferguson	ferguson	PROPN
dti-1378	611	5	km	km	PROPN
dti-1378	611	6	,	,	PUNCT
dti-1378	611	7	sternweis	sternweis	NOUN
dti-1378	611	8	pc	pc	NOUN
dti-1378	611	9	,	,	PUNCT
dti-1378	611	10	smigel	smigel	PROPN
dti-1378	611	11	md	md	PROPN
dti-1378	611	12	,	,	PUNCT
dti-1378	611	13	gilman	gilman	PROPN
dti-1378	611	14	ag	ag	PROPN
dti-1378	611	15	.	.	PROPN
dti-1378	611	16	effects	effect	NOUN
dti-1378	611	17	of	of	ADP
dti-1378	611	18	mg2	mg2	PROPN
dti-1378	611	19	+	+	PROPN
dti-1378	611	20	and	and	CCONJ
dti-1378	611	21	the	the	DET
dti-1378	611	22	beta	beta	ADJ
dti-1378	611	23	gamma	gamma	NOUN
dti-1378	611	24	-	-	PUNCT
dti-1378	611	25	subunit	subunit	NOUN
dti-1378	611	26	complex	complex	NOUN
dti-1378	611	27	on	on	ADP
dti-1378	611	28	the	the	DET
dti-1378	611	29	interactions	interaction	NOUN
dti-1378	611	30	of	of	ADP
dti-1378	611	31	guanine	guanine	NOUN
dti-1378	611	32	nucleotides	nucleotide	NOUN
dti-1378	611	33	with	with	ADP
dti-1378	611	34	g	g	NOUN
dti-1378	611	35	proteins	protein	NOUN
dti-1378	611	36	.	.	PUNCT
dti-1378	612	1	j	j	PROPN
dti-1378	612	2	biol	biol	PROPN
dti-1378	612	3	chem	chem	NOUN
dti-1378	612	4	.	.	PUNCT
dti-1378	613	1	1987;262(2):762–6	1987;262(2):762–6	NUM
dti-1378	613	2	.	.	PUNCT
dti-1378	614	1	55	55	NUM
dti-1378	614	2	.	.	PUNCT
dti-1378	615	1	ferguson	ferguson	PROPN
dti-1378	615	2	km	km	PROPN
dti-1378	615	3	,	,	PUNCT
dti-1378	615	4	higashijima	higashijima	PROPN
dti-1378	615	5	t	t	PROPN
dti-1378	615	6	,	,	PUNCT
dti-1378	615	7	smigel	smigel	PROPN
dti-1378	615	8	md	md	PROPN
dti-1378	615	9	,	,	PUNCT
dti-1378	615	10	gilman	gilman	PROPN
dti-1378	615	11	ag	ag	PROPN
dti-1378	615	12	.	.	PUNCT
dti-1378	616	1	the	the	DET
dti-1378	616	2	influence	influence	NOUN
dti-1378	616	3	of	of	ADP
dti-1378	616	4	bound	bind	VERB
dti-1378	616	5	gdp	gdp	NOUN
dti-1378	616	6	on	on	ADP
dti-1378	616	7	the	the	DET
dti-1378	616	8	kinetics	kinetic	NOUN
dti-1378	616	9	of	of	ADP
dti-1378	616	10	guanine	guanine	PROPN
dti-1378	616	11	nucleotide	nucleotide	NOUN
dti-1378	616	12	binding	bind	VERB
dti-1378	616	13	to	to	ADP
dti-1378	616	14	g	g	NOUN
dti-1378	616	15	proteins	protein	NOUN
dti-1378	616	16	.	.	PUNCT
dti-1378	617	1	j	j	PROPN
dti-1378	617	2	biol	biol	PROPN
dti-1378	617	3	chem	chem	NOUN
dti-1378	617	4	.	.	PUNCT
dti-1378	618	1	1986;261(16):7393–9	1986;261(16):7393–9	NUM
dti-1378	618	2	.	.	PUNCT
dti-1378	619	1	56	56	NUM
dti-1378	619	2	.	.	PUNCT
dti-1378	619	3	hepler	hepler	PROPN
dti-1378	619	4	jr	jr	PROPN
dti-1378	619	5	,	,	PUNCT
dti-1378	619	6	kozasa	kozasa	PROPN
dti-1378	619	7	t	t	PROPN
dti-1378	619	8	,	,	PUNCT
dti-1378	619	9	smrcka	smrcka	PROPN
dti-1378	619	10	av	av	PROPN
dti-1378	619	11	,	,	PUNCT
dti-1378	619	12	et	et	PROPN
dti-1378	619	13	al	al	PROPN
dti-1378	619	14	.	.	PUNCT
dti-1378	619	15	purification	purification	NOUN
dti-1378	619	16	from	from	ADP
dti-1378	619	17	sf9	sf9	NOUN
dti-1378	619	18	cells	cell	NOUN
dti-1378	619	19	and	and	CCONJ
dti-1378	619	20	characterization	characterization	NOUN
dti-1378	619	21	of	of	ADP
dti-1378	619	22	recombinant	recombinant	ADJ
dti-1378	619	23	gq	gq	NOUN
dti-1378	619	24	alpha	alpha	NOUN
dti-1378	619	25	and	and	CCONJ
dti-1378	619	26	g11	g11	PROPN
dti-1378	619	27	alpha	alpha	NOUN
dti-1378	619	28	.	.	PUNCT
dti-1378	620	1	activation	activation	NOUN
dti-1378	620	2	of	of	ADP
dti-1378	620	3	purified	purified	ADJ
dti-1378	620	4	phospholipase	phospholipase	NOUN
dti-1378	620	5	c	c	NOUN
dti-1378	620	6	isozymes	isozyme	NOUN
dti-1378	620	7	by	by	ADP
dti-1378	620	8	g	g	PROPN
dti-1378	620	9	alpha	alpha	NOUN
dti-1378	620	10	subunits	subunit	NOUN
dti-1378	620	11	.	.	PUNCT
dti-1378	621	1	j	j	PROPN
dti-1378	621	2	biol	biol	PROPN
dti-1378	621	3	chem	chem	NOUN
dti-1378	621	4	.	.	PUNCT
dti-1378	622	1	1993;268(19):14367–75	1993;268(19):14367–75	NUM
dti-1378	622	2	.	.	NOUN
dti-1378	622	3	57	57	NUM
dti-1378	622	4	.	.	PUNCT
dti-1378	623	1	gille	gille	VERB
dti-1378	623	2	a	a	PRON
dti-1378	623	3	,	,	PUNCT
dti-1378	623	4	liu	liu	PROPN
dti-1378	623	5	hy	hy	PROPN
dti-1378	623	6	,	,	PUNCT
dti-1378	623	7	sprang	sprang	PROPN
dti-1378	623	8	sr	sr	PROPN
dti-1378	623	9	,	,	PUNCT
dti-1378	623	10	seifert	seifert	PROPN
dti-1378	623	11	r.	r.	PROPN
dti-1378	623	12	distinct	distinct	PROPN
dti-1378	623	13	interactions	interaction	NOUN
dti-1378	623	14	of	of	ADP
dti-1378	623	15	gtp	gtp	NOUN
dti-1378	623	16	,	,	PUNCT
dti-1378	623	17	utp	utp	VERB
dti-1378	623	18	,	,	PUNCT
dti-1378	623	19	and	and	CCONJ
dti-1378	623	20	ctp	ctp	PROPN
dti-1378	623	21	with	with	ADP
dti-1378	623	22	g(s	g(	NOUN
dti-1378	623	23	)	)	PUNCT
dti-1378	623	24	proteins	protein	NOUN
dti-1378	623	25	.	.	PUNCT
dti-1378	624	1	j	j	PROPN
dti-1378	624	2	biol	biol	PROPN
dti-1378	624	3	chem	chem	NOUN
dti-1378	624	4	.	.	PUNCT
dti-1378	625	1	2002;277(37):34434–42	2002;277(37):34434–42	NUM
dti-1378	625	2	.	.	PROPN
dti-1378	625	3	58	58	NUM
dti-1378	625	4	.	.	PUNCT
dti-1378	626	1	weitmann	weitmann	PROPN
dti-1378	626	2	s	s	PART
dti-1378	626	3	,	,	PUNCT
dti-1378	626	4	schultz	schultz	PROPN
dti-1378	626	5	g	g	PROPN
dti-1378	626	6	,	,	PUNCT
dti-1378	626	7	kleuss	kleuss	PROPN
dti-1378	626	8	c.	c.	PROPN
dti-1378	626	9	adenylyl	adenylyl	PROPN
dti-1378	626	10	cyclase	cyclase	NOUN
dti-1378	626	11	type	type	NOUN
dti-1378	626	12	ii	ii	NOUN
dti-1378	626	13	domains	domain	NOUN
dti-1378	626	14	involved	involve	VERB
dti-1378	626	15	in	in	ADP
dti-1378	626	16	gbetagamma	gbetagamma	NOUN
dti-1378	626	17	stimulation	stimulation	NOUN
dti-1378	626	18	.	.	PUNCT
dti-1378	627	1	biochemistry	biochemistry	NOUN
dti-1378	627	2	.	.	PUNCT
dti-1378	628	1	2001;40(36):10853–8	2001;40(36):10853–8	X
dti-1378	628	2	.	.	X
dti-1378	629	1	59	59	NUM
dti-1378	629	2	.	.	PUNCT
dti-1378	630	1	willard	willard	PROPN
dti-1378	630	2	fs	fs	PROPN
dti-1378	630	3	,	,	PUNCT
dti-1378	630	4	kimple	kimple	PROPN
dti-1378	630	5	rj	rj	PROPN
dti-1378	630	6	,	,	PUNCT
dti-1378	630	7	kimple	kimple	PROPN
dti-1378	630	8	aj	aj	PROPN
dti-1378	630	9	,	,	PUNCT
dti-1378	630	10	johnston	johnston	PROPN
dti-1378	630	11	ca	ca	PROPN
dti-1378	630	12	,	,	PUNCT
dti-1378	630	13	siderovski	siderovski	PROPN
dti-1378	630	14	dp	dp	PROPN
dti-1378	630	15	.	.	PUNCT
dti-1378	631	1	fluorescence	fluorescence	NOUN
dti-1378	631	2	-	-	PUNCT
dti-1378	631	3	based	base	VERB
dti-1378	631	4	assays	assay	NOUN
dti-1378	631	5	for	for	ADP
dti-1378	631	6	rgs	rgs	PROPN
dti-1378	631	7	box	box	PROPN
dti-1378	631	8	function	function	PROPN
dti-1378	631	9	.	.	PUNCT
dti-1378	632	1	methods	method	NOUN
dti-1378	632	2	enzymol	enzymol	PROPN
dti-1378	632	3	.	.	PUNCT
dti-1378	633	1	2004	2004	NUM
dti-1378	633	2	;	;	PUNCT
dti-1378	634	1	389:56–71	389:56–71	NUM
dti-1378	634	2	.	.	PROPN
dti-1378	634	3	60	60	NUM
dti-1378	634	4	.	.	PUNCT
dti-1378	634	5	takesono	takesono	PROPN
dti-1378	634	6	a	a	DET
dti-1378	634	7	,	,	PUNCT
dti-1378	634	8	cismowski	cismowski	PROPN
dti-1378	634	9	mj	mj	PROPN
dti-1378	634	10	,	,	PUNCT
dti-1378	634	11	ribas	ribas	PROPN
dti-1378	634	12	c	c	PROPN
dti-1378	634	13	,	,	PUNCT
dti-1378	634	14	et	et	PROPN
dti-1378	634	15	al	al	PROPN
dti-1378	634	16	.	.	PUNCT
dti-1378	635	1	receptor	receptor	NOUN
dti-1378	635	2	-	-	PUNCT
dti-1378	635	3	independent	independent	ADJ
dti-1378	635	4	activators	activator	NOUN
dti-1378	635	5	of	of	ADP
dti-1378	635	6	heterotrimeric	heterotrimeric	ADJ
dti-1378	635	7	g	g	NOUN
dti-1378	635	8	-	-	PUNCT
dti-1378	635	9	protein	protein	NOUN
dti-1378	635	10	signaling	signal	VERB
dti-1378	635	11	pathways	pathway	NOUN
dti-1378	635	12	.	.	PUNCT
dti-1378	636	1	j	j	PROPN
dti-1378	636	2	biol	biol	PROPN
dti-1378	636	3	chem	chem	NOUN
dti-1378	636	4	.	.	PUNCT
dti-1378	637	1	1999	1999	NUM
dti-1378	637	2	;	;	PUNCT
dti-1378	638	1	274(47):33202–5	274(47):33202–5	PROPN
dti-1378	638	2	.	.	PROPN
dti-1378	639	1	61	61	NUM
dti-1378	639	2	.	.	PUNCT
dti-1378	640	1	milburn	milburn	PROPN
dti-1378	640	2	mv	mv	PROPN
dti-1378	640	3	,	,	PUNCT
dti-1378	640	4	tong	tong	PROPN
dti-1378	640	5	l	l	PROPN
dti-1378	640	6	,	,	PUNCT
dti-1378	640	7	devos	devos	PROPN
dti-1378	640	8	am	am	NOUN
dti-1378	640	9	,	,	PUNCT
dti-1378	640	10	et	et	PROPN
dti-1378	640	11	al	al	PROPN
dti-1378	640	12	.	.	PROPN
dti-1378	641	1	molecular	molecular	ADJ
dti-1378	641	2	switch	switch	NOUN
dti-1378	641	3	for	for	ADP
dti-1378	641	4	signal	signal	ADJ
dti-1378	641	5	transduction	transduction	NOUN
dti-1378	641	6	:	:	PUNCT
dti-1378	641	7	structural	structural	ADJ
dti-1378	641	8	differences	difference	NOUN
dti-1378	641	9	between	between	ADP
dti-1378	641	10	active	active	ADJ
dti-1378	641	11	and	and	CCONJ
dti-1378	641	12	inactive	inactive	ADJ
dti-1378	641	13	forms	form	NOUN
dti-1378	641	14	of	of	ADP
dti-1378	641	15	protooncogenic	protooncogenic	ADJ
dti-1378	641	16	ras	ras	NOUN
dti-1378	641	17	proteins	protein	NOUN
dti-1378	641	18	.	.	PUNCT
dti-1378	642	1	science	science	NOUN
dti-1378	642	2	.	.	PUNCT
dti-1378	643	1	1990;247(4945):939–45	1990;247(4945):939–45	X
dti-1378	643	2	.	.	PUNCT
dti-1378	644	1	62	62	NUM
dti-1378	644	2	.	.	PUNCT
dti-1378	645	1	schlichting	schlichte	VERB
dti-1378	645	2	i	i	PRON
dti-1378	645	3	,	,	PUNCT
dti-1378	645	4	almo	almo	PROPN
dti-1378	645	5	sc	sc	PROPN
dti-1378	645	6	,	,	PUNCT
dti-1378	645	7	rapp	rapp	PROPN
dti-1378	645	8	g	g	PROPN
dti-1378	645	9	,	,	PUNCT
dti-1378	645	10	et	et	PROPN
dti-1378	645	11	al	al	PROPN
dti-1378	645	12	.	.	PROPN
dti-1378	645	13	time	time	NOUN
dti-1378	645	14	-	-	PUNCT
dti-1378	645	15	resolved	resolve	VERB
dti-1378	645	16	x	x	ADJ
dti-1378	645	17	-	-	NOUN
dti-1378	645	18	ray	ray	ADJ
dti-1378	645	19	crystallographic	crystallographic	ADJ
dti-1378	645	20	study	study	NOUN
dti-1378	645	21	of	of	ADP
dti-1378	645	22	the	the	DET
dti-1378	645	23	conformational	conformational	ADJ
dti-1378	645	24	change	change	NOUN
dti-1378	645	25	in	in	ADP
dti-1378	645	26	ha	ha	ADJ
dti-1378	645	27	-	-	PUNCT
dti-1378	645	28	ras	ras	ADJ
dti-1378	645	29	p21	p21	NOUN
dti-1378	645	30	protein	protein	NOUN
dti-1378	645	31	on	on	ADP
dti-1378	645	32	gtp	gtp	NOUN
dti-1378	645	33	hydrolysis	hydrolysis	NOUN
dti-1378	645	34	.	.	PUNCT
dti-1378	646	1	nature	nature	NOUN
dti-1378	646	2	.	.	PUNCT
dti-1378	647	1	1990;345(6273):309–15	1990;345(6273):309–15	NUM
dti-1378	647	2	.	.	PUNCT
dti-1378	648	1	63	63	NUM
dti-1378	648	2	.	.	PUNCT
dti-1378	649	1	kraulis	kraulis	PROPN
dti-1378	649	2	pj	pj	PROPN
dti-1378	649	3	,	,	PUNCT
dti-1378	649	4	domaille	domaille	PROPN
dti-1378	649	5	pj	pj	PROPN
dti-1378	649	6	,	,	PUNCT
dti-1378	649	7	campbell	campbell	PROPN
dti-1378	649	8	-	-	PUNCT
dti-1378	649	9	burk	burk	PROPN
dti-1378	649	10	sl	sl	PROPN
dti-1378	649	11	,	,	PUNCT
dti-1378	649	12	van	van	PROPN
dti-1378	649	13	aken	aken	VERB
dti-1378	649	14	t	t	PROPN
dti-1378	649	15	,	,	PUNCT
dti-1378	649	16	laue	laue	VERB
dti-1378	650	1	ed	ed	NOUN
dti-1378	650	2	.	.	PUNCT
dti-1378	650	3	solution	solution	NOUN
dti-1378	650	4	structure	structure	NOUN
dti-1378	650	5	and	and	CCONJ
dti-1378	650	6	dynamics	dynamic	NOUN
dti-1378	650	7	of	of	ADP
dti-1378	650	8	ras	ras	PROPN
dti-1378	650	9	p21.gdp	p21.gdp	PROPN
dti-1378	650	10	determined	determine	VERB
dti-1378	650	11	by	by	ADP
dti-1378	650	12	heteronuclear	heteronuclear	ADJ
dti-1378	650	13	threeand	threeand	NOUN
dti-1378	650	14	four	four	NUM
dti-1378	650	15	-	-	PUNCT
dti-1378	650	16	dimensional	dimensional	ADJ
dti-1378	650	17	nmr	nmr	NOUN
dti-1378	650	18	spectroscopy	spectroscopy	NOUN
dti-1378	650	19	.	.	PUNCT
dti-1378	651	1	biochemistry	biochemistry	NOUN
dti-1378	651	2	.	.	PUNCT
dti-1378	652	1	1994;33(12):3515–31	1994;33(12):3515–31	NUM
dti-1378	652	2	.	.	X
dti-1378	653	1	64	64	NUM
dti-1378	653	2	.	.	PUNCT
dti-1378	654	1	calés	calés	PROPN
dti-1378	654	2	c	c	PROPN
dti-1378	654	3	,	,	PUNCT
dti-1378	654	4	hancock	hancock	PROPN
dti-1378	654	5	jf	jf	PROPN
dti-1378	654	6	,	,	PUNCT
dti-1378	654	7	marshall	marshall	PROPN
dti-1378	654	8	cj	cj	PROPN
dti-1378	654	9	,	,	PUNCT
dti-1378	654	10	hall	hall	PROPN
dti-1378	654	11	a.	a.	PROPN
dti-1378	654	12	the	the	DET
dti-1378	654	13	cytoplasmic	cytoplasmic	ADJ
dti-1378	654	14	protein	protein	NOUN
dti-1378	654	15	gap	gap	NOUN
dti-1378	654	16	is	be	AUX
dti-1378	654	17	implicated	implicate	VERB
dti-1378	654	18	as	as	ADP
dti-1378	654	19	the	the	DET
dti-1378	654	20	target	target	NOUN
dti-1378	654	21	for	for	ADP
dti-1378	654	22	regulation	regulation	NOUN
dti-1378	654	23	by	by	ADP
dti-1378	654	24	the	the	DET
dti-1378	654	25	ras	ras	PROPN
dti-1378	654	26	gene	gene	NOUN
dti-1378	654	27	product	product	NOUN
dti-1378	654	28	.	.	PUNCT
dti-1378	655	1	nature	nature	NOUN
dti-1378	655	2	.	.	PUNCT
dti-1378	656	1	1988;332(6164):548–51	1988;332(6164):548–51	NUM
dti-1378	656	2	.	.	PUNCT
dti-1378	657	1	65	65	NUM
dti-1378	657	2	.	.	PUNCT
dti-1378	658	1	adari	adari	ADJ
dti-1378	658	2	h	h	NOUN
dti-1378	658	3	,	,	PUNCT
dti-1378	658	4	lowy	lowy	PROPN
dti-1378	658	5	dr	dr	PROPN
dti-1378	658	6	,	,	PUNCT
dti-1378	658	7	willumsen	willumsen	PROPN
dti-1378	658	8	bm	bm	PROPN
dti-1378	658	9	,	,	PUNCT
dti-1378	658	10	der	der	PROPN
dti-1378	658	11	cj	cj	PROPN
dti-1378	658	12	,	,	PUNCT
dti-1378	658	13	mccormick	mccormick	PROPN
dti-1378	658	14	f.	f.	PROPN
dti-1378	658	15	guanosine	guanosine	PROPN
dti-1378	658	16	triphosphatase	triphosphatase	NOUN
dti-1378	658	17	activating	activate	VERB
dti-1378	658	18	protein	protein	NOUN
dti-1378	658	19	(	(	PUNCT
dti-1378	658	20	gap	gap	NOUN
dti-1378	658	21	)	)	PUNCT
dti-1378	658	22	interacts	interact	VERB
dti-1378	658	23	with	with	ADP
dti-1378	658	24	the	the	DET
dti-1378	658	25	p21	p21	PROPN
dti-1378	658	26	ras	ras	PROPN
dti-1378	658	27	effector	effector	NOUN
dti-1378	658	28	binding	bind	VERB
dti-1378	658	29	domain	domain	NOUN
dti-1378	658	30	.	.	PUNCT
dti-1378	659	1	science	science	NOUN
dti-1378	659	2	.	.	PUNCT
dti-1378	660	1	1988;240(4851):518–21	1988;240(4851):518–21	NUM
dti-1378	660	2	.	.	PUNCT
dti-1378	661	1	66	66	NUM
dti-1378	661	2	.	.	PUNCT
dti-1378	661	3	greasley	greasley	PROPN
dti-1378	661	4	se	se	PROPN
dti-1378	661	5	,	,	PUNCT
dti-1378	661	6	jhoti	jhoti	PROPN
dti-1378	661	7	h	h	PROPN
dti-1378	661	8	,	,	PUNCT
dti-1378	661	9	teahan	teahan	ADP
dti-1378	661	10	c	c	NOUN
dti-1378	661	11	,	,	PUNCT
dti-1378	661	12	et	et	PROPN
dti-1378	661	13	al	al	PROPN
dti-1378	661	14	.	.	PUNCT
dti-1378	662	1	the	the	DET
dti-1378	662	2	structure	structure	NOUN
dti-1378	662	3	of	of	ADP
dti-1378	662	4	rat	rat	NOUN
dti-1378	662	5	adp	adp	PROPN
dti-1378	662	6	-	-	PUNCT
dti-1378	662	7	ribosylation	ribosylation	NOUN
dti-1378	662	8	factor-1	factor-1	PROPN
dti-1378	662	9	(	(	PUNCT
dti-1378	662	10	arf-1	arf-1	NOUN
dti-1378	662	11	)	)	PUNCT
dti-1378	662	12	complexed	complexe	VERB
dti-1378	662	13	to	to	ADP
dti-1378	662	14	gdp	gdp	NOUN
dti-1378	662	15	determined	determine	VERB
dti-1378	662	16	from	from	ADP
dti-1378	662	17	two	two	NUM
dti-1378	662	18	different	different	ADJ
dti-1378	662	19	crystal	crystal	NOUN
dti-1378	662	20	forms	form	NOUN
dti-1378	662	21	.	.	PUNCT
dti-1378	663	1	nat	nat	PROPN
dti-1378	663	2	struct	struct	NOUN
dti-1378	663	3	biol	biol	NOUN
dti-1378	663	4	.	.	PUNCT
dti-1378	664	1	1995;2(9):797–806	1995;2(9):797–806	NUM
dti-1378	664	2	.	.	PUNCT
dti-1378	664	3	http://www.la-press.com	http://www.la-press.com	X