id	sid	tid	token	lemma	pos
dti-1400	1	1	https://doi.org/10.1177/1177392818782899	https://doi.org/10.1177/1177392818782899	NOUN
dti-1400	1	2	drug	drug	NOUN
dti-1400	1	3	target	target	NOUN
dti-1400	1	4	insights	insight	NOUN
dti-1400	1	5	volume	volume	VERB
dti-1400	1	6	12	12	NUM
dti-1400	1	7	:	:	PUNCT
dti-1400	1	8	1–5	1–5	NUM
dti-1400	1	9	©	©	ADP
dti-1400	1	10	the	the	DET
dti-1400	1	11	author(s	author(s	NOUN
dti-1400	1	12	)	)	PUNCT
dti-1400	1	13	2018	2018	NUM
dti-1400	1	14	reprints	reprint	NOUN
dti-1400	1	15	and	and	CCONJ
dti-1400	1	16	permissions	permission	NOUN
dti-1400	1	17	:	:	PUNCT
dti-1400	2	1	sagepub.co.uk/journalspermissions.nav	sagepub.co.uk/journalspermissions.nav	PROPN
dti-1400	2	2	doi	doi	PROPN
dti-1400	2	3	:	:	PUNCT
dti-1400	2	4	10.1177/1177392818782899	10.1177/1177392818782899	NUM
dti-1400	2	5	creative	creative	ADJ
dti-1400	2	6	commons	common	NOUN
dti-1400	2	7	non	non	ADJ
dti-1400	2	8	commercial	commercial	PROPN
dti-1400	2	9	cc	cc	PROPN
dti-1400	2	10	by	by	ADP
dti-1400	2	11	-	-	PUNCT
dti-1400	2	12	nc	nc	PROPN
dti-1400	2	13	:	:	PUNCT
dti-1400	2	14	this	this	DET
dti-1400	2	15	article	article	NOUN
dti-1400	2	16	is	be	AUX
dti-1400	2	17	distributed	distribute	VERB
dti-1400	2	18	under	under	ADP
dti-1400	2	19	the	the	DET
dti-1400	2	20	terms	term	NOUN
dti-1400	2	21	of	of	ADP
dti-1400	2	22	the	the	DET
dti-1400	2	23	creative	creative	ADJ
dti-1400	2	24	commons	common	NOUN
dti-1400	2	25	attribution	attribution	NOUN
dti-1400	2	26	-	-	PUNCT
dti-1400	2	27	noncommercial	noncommercial	ADJ
dti-1400	2	28	4.0	4.0	NUM
dti-1400	2	29	license	license	NOUN
dti-1400	2	30	(	(	PUNCT
dti-1400	2	31	http://www.creativecommons.org/licenses/by-nc/4.0/	http://www.creativecommons.org/licenses/by-nc/4.0/	PROPN
dti-1400	2	32	)	)	PUNCT
dti-1400	2	33	which	which	PRON
dti-1400	2	34	permits	permit	VERB
dti-1400	2	35	non	non	ADJ
dti-1400	2	36	-	-	ADJ
dti-1400	2	37	commercial	commercial	ADJ
dti-1400	2	38	use	use	NOUN
dti-1400	2	39	,	,	PUNCT
dti-1400	2	40	reproduction	reproduction	NOUN
dti-1400	2	41	and	and	CCONJ
dti-1400	2	42	distribution	distribution	NOUN
dti-1400	2	43	of	of	ADP
dti-1400	2	44	the	the	DET
dti-1400	2	45	work	work	NOUN
dti-1400	2	46	without	without	ADP
dti-1400	2	47	further	further	ADJ
dti-1400	2	48	permission	permission	NOUN
dti-1400	2	49	provided	provide	VERB
dti-1400	2	50	the	the	DET
dti-1400	2	51	original	original	ADJ
dti-1400	2	52	work	work	NOUN
dti-1400	2	53	is	be	AUX
dti-1400	2	54	attributed	attribute	VERB
dti-1400	2	55	as	as	ADP
dti-1400	2	56	specified	specify	VERB
dti-1400	2	57	on	on	ADP
dti-1400	2	58	the	the	DET
dti-1400	2	59	sage	sage	NOUN
dti-1400	2	60	and	and	CCONJ
dti-1400	2	61	open	open	ADJ
dti-1400	2	62	access	access	NOUN
dti-1400	2	63	pages	page	NOUN
dti-1400	2	64	(	(	PUNCT
dti-1400	2	65	https://us.sagepub.com/en-us/nam/open-access-at-sage	https://us.sagepub.com/en-us/nam/open-access-at-sage	NOUN
dti-1400	2	66	)	)	PUNCT
dti-1400	2	67	.	.	PUNCT
dti-1400	3	1	introduction	introduction	NOUN
dti-1400	3	2	the	the	DET
dti-1400	3	3	administration	administration	NOUN
dti-1400	3	4	of	of	ADP
dti-1400	3	5	acyclovir	acyclovir	PROPN
dti-1400	3	6	antiviral	antiviral	PROPN
dti-1400	3	7	therapy	therapy	PROPN
dti-1400	3	8	has	have	AUX
dti-1400	3	9	been	be	AUX
dti-1400	3	10	a	a	DET
dti-1400	3	11	treatment	treatment	NOUN
dti-1400	3	12	option	option	NOUN
dti-1400	3	13	for	for	ADP
dti-1400	3	14	varicella	varicella	NOUN
dti-1400	3	15	zoster	zoster	NOUN
dti-1400	3	16	virus	virus	NOUN
dti-1400	3	17	infection.1,2	infection.1,2	ADJ
dti-1400	3	18	valacyclovir	valacyclovir	PROPN
dti-1400	3	19	is	be	AUX
dti-1400	3	20	the	the	DET
dti-1400	3	21	valyl	valyl	ADJ
dti-1400	3	22	ester	ester	NOUN
dti-1400	3	23	of	of	ADP
dti-1400	3	24	acyclovir	acyclovir	PROPN
dti-1400	3	25	and	and	CCONJ
dti-1400	3	26	after	after	ADP
dti-1400	3	27	its	its	PRON
dti-1400	3	28	oral	oral	ADJ
dti-1400	3	29	administration	administration	NOUN
dti-1400	3	30	it	it	PRON
dti-1400	3	31	undergoes	undergo	VERB
dti-1400	3	32	first	first	ADJ
dti-1400	3	33	-	-	PUNCT
dti-1400	3	34	pass	pass	VERB
dti-1400	3	35	intestinal	intestinal	ADJ
dti-1400	3	36	and/or	and/or	CCONJ
dti-1400	3	37	hepatic	hepatic	ADJ
dti-1400	3	38	metabolism	metabolism	NOUN
dti-1400	3	39	to	to	PART
dti-1400	3	40	produce	produce	VERB
dti-1400	3	41	active	active	ADJ
dti-1400	3	42	-	-	PUNCT
dti-1400	3	43	moiety	moiety	NOUN
dti-1400	3	44	acyclovir	acyclovir	PROPN
dti-1400	3	45	and	and	CCONJ
dti-1400	3	46	l	l	NOUN
dti-1400	3	47	-	-	NOUN
dti-1400	3	48	valine	valine	NOUN
dti-1400	3	49	at	at	ADP
dti-1400	3	50	a	a	DET
dti-1400	3	51	high	high	ADJ
dti-1400	3	52	bioavailability	bioavailability	NOUN
dti-1400	3	53	that	that	PRON
dti-1400	3	54	is	be	AUX
dti-1400	3	55	several	several	ADJ
dti-1400	3	56	times	time	NOUN
dti-1400	3	57	greater	great	ADJ
dti-1400	3	58	than	than	ADP
dti-1400	3	59	that	that	PRON
dti-1400	3	60	obtained	obtain	VERB
dti-1400	3	61	from	from	ADP
dti-1400	3	62	oral	oral	ADJ
dti-1400	3	63	acyclovir.1,3	acyclovir.1,3	PROPN
dti-1400	3	64	both	both	DET
dti-1400	3	65	agents	agent	NOUN
dti-1400	3	66	are	be	AUX
dti-1400	3	67	well	well	ADV
dti-1400	3	68	tolerated	tolerate	VERB
dti-1400	3	69	in	in	ADP
dti-1400	3	70	the	the	DET
dti-1400	3	71	ordinary	ordinary	ADJ
dti-1400	3	72	clinical	clinical	ADJ
dti-1400	3	73	settings	setting	NOUN
dti-1400	3	74	;	;	PUNCT
dti-1400	3	75	however	however	ADV
dti-1400	3	76	,	,	PUNCT
dti-1400	3	77	it	it	PRON
dti-1400	3	78	is	be	AUX
dti-1400	3	79	not	not	PART
dti-1400	3	80	surprising	surprising	ADJ
dti-1400	3	81	that	that	SCONJ
dti-1400	3	82	acyclovir	acyclovir	PROPN
dti-1400	3	83	and	and	CCONJ
dti-1400	3	84	oral	oral	ADJ
dti-1400	3	85	valacyclovir	valacyclovir	NOUN
dti-1400	3	86	share	share	VERB
dti-1400	3	87	an	an	DET
dti-1400	3	88	adverse	adverse	ADJ
dti-1400	3	89	event	event	NOUN
dti-1400	3	90	profile	profile	NOUN
dti-1400	3	91	that	that	PRON
dti-1400	3	92	is	be	AUX
dti-1400	3	93	both	both	PRON
dti-1400	3	94	qualitatively	qualitatively	ADV
dti-1400	3	95	and	and	CCONJ
dti-1400	3	96	quantitatively	quantitatively	ADV
dti-1400	3	97	similar.1	similar.1	VERB
dti-1400	3	98	subjects	subject	NOUN
dti-1400	3	99	with	with	ADP
dti-1400	3	100	chronic	chronic	ADJ
dti-1400	3	101	renal	renal	ADJ
dti-1400	3	102	insufficiency	insufficiency	NOUN
dti-1400	3	103	are	be	AUX
dti-1400	3	104	susceptible	susceptible	ADJ
dti-1400	3	105	to	to	ADP
dti-1400	3	106	adverse	adverse	ADJ
dti-1400	3	107	events	event	NOUN
dti-1400	3	108	characterized	characterize	VERB
dti-1400	3	109	by	by	ADP
dti-1400	3	110	neuropsychiatric	neuropsychiatric	ADJ
dti-1400	3	111	manifestations.3,4	manifestations.3,4	PROPN
dti-1400	3	112	as	as	ADP
dti-1400	3	113	such	such	ADJ
dti-1400	3	114	,	,	PUNCT
dti-1400	3	115	dosing	dose	VERB
dti-1400	3	116	adjustments	adjustment	NOUN
dti-1400	3	117	proportionate	proportionate	ADJ
dti-1400	3	118	to	to	ADP
dti-1400	3	119	renal	renal	ADJ
dti-1400	3	120	impairment	impairment	NOUN
dti-1400	3	121	may	may	AUX
dti-1400	3	122	be	be	AUX
dti-1400	3	123	required.1,2	required.1,2	ADJ
dti-1400	3	124	in	in	ADP
dti-1400	3	125	this	this	DET
dti-1400	3	126	report	report	NOUN
dti-1400	3	127	,	,	PUNCT
dti-1400	3	128	we	we	PRON
dti-1400	3	129	describe	describe	VERB
dti-1400	3	130	our	our	PRON
dti-1400	3	131	experience	experience	NOUN
dti-1400	3	132	with	with	ADP
dti-1400	3	133	a	a	DET
dti-1400	3	134	case	case	NOUN
dti-1400	3	135	of	of	ADP
dti-1400	3	136	valacyclovir	valacyclovir	PROPN
dti-1400	3	137	neurotoxicity	neurotoxicity	NOUN
dti-1400	3	138	accompanied	accompany	VERB
dti-1400	3	139	by	by	ADP
dti-1400	3	140	acute	acute	ADJ
dti-1400	3	141	kidney	kidney	PROPN
dti-1400	3	142	injury	injury	NOUN
dti-1400	3	143	(	(	PUNCT
dti-1400	3	144	aki	aki	NOUN
dti-1400	3	145	)	)	PUNCT
dti-1400	3	146	in	in	ADP
dti-1400	3	147	an	an	DET
dti-1400	3	148	aged	aged	ADJ
dti-1400	3	149	female	female	ADJ
dti-1400	3	150	patient	patient	NOUN
dti-1400	3	151	who	who	PRON
dti-1400	3	152	barely	barely	ADV
dti-1400	3	153	appeared	appear	VERB
dti-1400	3	154	to	to	PART
dti-1400	3	155	have	have	VERB
dti-1400	3	156	acceptable	acceptable	ADJ
dti-1400	3	157	renal	renal	ADJ
dti-1400	3	158	function	function	NOUN
dti-1400	3	159	to	to	PART
dti-1400	3	160	receive	receive	VERB
dti-1400	3	161	the	the	DET
dti-1400	3	162	agent	agent	NOUN
dti-1400	3	163	at	at	ADP
dti-1400	3	164	the	the	DET
dti-1400	3	165	standard	standard	ADJ
dti-1400	3	166	dosage	dosage	NOUN
dti-1400	3	167	for	for	ADP
dti-1400	3	168	the	the	DET
dti-1400	3	169	treatment	treatment	NOUN
dti-1400	3	170	of	of	ADP
dti-1400	3	171	herpes	herpe	NOUN
dti-1400	3	172	zoster	zoster	NOUN
dti-1400	3	173	(	(	PUNCT
dti-1400	3	174	hz	hz	PROPN
dti-1400	3	175	)	)	PUNCT
dti-1400	3	176	.	.	PUNCT
dti-1400	4	1	several	several	ADJ
dti-1400	4	2	management	management	NOUN
dti-1400	4	3	concerns	concern	NOUN
dti-1400	4	4	that	that	PRON
dti-1400	4	5	emerged	emerge	VERB
dti-1400	4	6	in	in	ADP
dti-1400	4	7	the	the	DET
dti-1400	4	8	current	current	ADJ
dti-1400	4	9	case	case	NOUN
dti-1400	4	10	are	be	AUX
dti-1400	4	11	also	also	ADV
dti-1400	4	12	discussed	discuss	VERB
dti-1400	4	13	.	.	PUNCT
dti-1400	5	1	case	case	NOUN
dti-1400	5	2	report	report	VERB
dti-1400	5	3	a	a	DET
dti-1400	5	4	66	66	NUM
dti-1400	5	5	-	-	PUNCT
dti-1400	5	6	year	year	NOUN
dti-1400	5	7	-	-	PUNCT
dti-1400	5	8	old	old	ADJ
dti-1400	5	9	woman	woman	NOUN
dti-1400	5	10	with	with	ADP
dti-1400	5	11	a	a	DET
dti-1400	5	12	history	history	NOUN
dti-1400	5	13	of	of	ADP
dti-1400	5	14	hypertension	hypertension	NOUN
dti-1400	5	15	and	and	CCONJ
dti-1400	5	16	hyperlipidemia	hyperlipidemia	NOUN
dti-1400	5	17	was	be	AUX
dti-1400	5	18	referred	refer	VERB
dti-1400	5	19	and	and	CCONJ
dti-1400	5	20	admitted	admit	VERB
dti-1400	5	21	to	to	ADP
dti-1400	5	22	our	our	PRON
dti-1400	5	23	hospital	hospital	NOUN
dti-1400	5	24	in	in	ADP
dti-1400	5	25	the	the	DET
dti-1400	5	26	middle	middle	NOUN
dti-1400	5	27	of	of	ADP
dti-1400	5	28	november	november	PROPN
dti-1400	5	29	2015	2015	NUM
dti-1400	5	30	due	due	ADP
dti-1400	5	31	to	to	ADP
dti-1400	5	32	coma	coma	NOUN
dti-1400	5	33	accompanied	accompany	VERB
dti-1400	5	34	by	by	ADP
dti-1400	5	35	aki	aki	PROPN
dti-1400	5	36	.	.	PROPN
dti-1400	5	37	six	six	NUM
dti-1400	5	38	years	year	NOUN
dti-1400	5	39	earlier	early	ADV
dti-1400	5	40	,	,	PUNCT
dti-1400	5	41	she	she	PRON
dti-1400	5	42	had	have	AUX
dti-1400	5	43	been	be	AUX
dti-1400	5	44	found	find	VERB
dti-1400	5	45	to	to	PART
dti-1400	5	46	have	have	VERB
dti-1400	5	47	these	these	DET
dti-1400	5	48	diseases	disease	NOUN
dti-1400	5	49	and	and	CCONJ
dti-1400	5	50	had	have	AUX
dti-1400	5	51	been	be	AUX
dti-1400	5	52	treated	treat	VERB
dti-1400	5	53	with	with	ADP
dti-1400	5	54	atorvastatin	atorvastatin	NOUN
dti-1400	5	55	as	as	ADV
dti-1400	5	56	well	well	ADV
dti-1400	5	57	as	as	ADP
dti-1400	5	58	antihypertensive	antihypertensive	ADJ
dti-1400	5	59	agents	agent	NOUN
dti-1400	5	60	,	,	PUNCT
dti-1400	5	61	including	include	VERB
dti-1400	5	62	amlodipine	amlodipine	PROPN
dti-1400	5	63	,	,	PUNCT
dti-1400	5	64	olmesartan	olmesartan	PROPN
dti-1400	5	65	medoxomil	medoxomil	PROPN
dti-1400	5	66	,	,	PUNCT
dti-1400	5	67	and	and	CCONJ
dti-1400	5	68	carvedilol	carvedilol	NOUN
dti-1400	5	69	.	.	PUNCT
dti-1400	6	1	although	although	SCONJ
dti-1400	6	2	the	the	DET
dti-1400	6	3	renal	renal	ADJ
dti-1400	6	4	parameters	parameter	NOUN
dti-1400	6	5	had	have	AUX
dti-1400	6	6	not	not	PART
dti-1400	6	7	been	be	AUX
dti-1400	6	8	monitored	monitor	VERB
dti-1400	6	9	on	on	ADP
dti-1400	6	10	a	a	DET
dti-1400	6	11	regular	regular	ADJ
dti-1400	6	12	basis	basis	NOUN
dti-1400	6	13	,	,	PUNCT
dti-1400	6	14	her	her	PRON
dti-1400	6	15	serum	serum	NOUN
dti-1400	6	16	creatinine	creatinine	NOUN
dti-1400	6	17	(	(	PUNCT
dti-1400	6	18	scr	scr	NOUN
dti-1400	6	19	)	)	PUNCT
dti-1400	6	20	level	level	NOUN
dti-1400	6	21	slightly	slightly	ADV
dti-1400	6	22	increased	increase	VERB
dti-1400	6	23	from	from	ADP
dti-1400	6	24	0.58	0.58	NUM
dti-1400	6	25	mg	mg	PROPN
dti-1400	6	26	/	/	SYM
dti-1400	6	27	dl	dl	PROPN
dti-1400	6	28	in	in	ADP
dti-1400	6	29	july	july	PROPN
dti-1400	6	30	2013	2013	NUM
dti-1400	6	31	to	to	ADP
dti-1400	6	32	0.69	0.69	NUM
dti-1400	6	33	mg	mg	PROPN
dti-1400	6	34	/	/	SYM
dti-1400	6	35	dl	dl	PROPN
dti-1400	6	36	in	in	ADP
dti-1400	6	37	september	september	PROPN
dti-1400	6	38	2015	2015	NUM
dti-1400	6	39	,	,	PUNCT
dti-1400	6	40	indicating	indicate	VERB
dti-1400	6	41	declines	decline	NOUN
dti-1400	6	42	in	in	ADP
dti-1400	6	43	the	the	DET
dti-1400	6	44	estimated	estimate	VERB
dti-1400	6	45	cr	cr	PROPN
dti-1400	6	46	clearance	clearance	PROPN
dti-1400	6	47	(	(	PUNCT
dti-1400	6	48	ecrcl	ecrcl	NOUN
dti-1400	6	49	)	)	PUNCT
dti-1400	6	50	determined	determine	VERB
dti-1400	6	51	by	by	ADP
dti-1400	6	52	cockcroft	cockcroft	PROPN
dti-1400	6	53	-	-	PUNCT
dti-1400	6	54	gault	gault	PROPN
dti-1400	6	55	formula5	formula5	PROPN
dti-1400	6	56	and	and	CCONJ
dti-1400	6	57	the	the	DET
dti-1400	6	58	estimated	estimate	VERB
dti-1400	6	59	glomerular	glomerular	ADJ
dti-1400	6	60	filtration	filtration	NOUN
dti-1400	6	61	rate	rate	NOUN
dti-1400	6	62	(	(	PUNCT
dti-1400	6	63	egfr	egfr	X
dti-1400	6	64	)	)	PUNCT
dti-1400	6	65	based	base	VERB
dti-1400	6	66	on	on	ADP
dti-1400	6	67	the	the	DET
dti-1400	6	68	revised	revise	VERB
dti-1400	6	69	japanese	japanese	ADJ
dti-1400	6	70	equation6	equation6	NOUN
dti-1400	6	71	from	from	ADP
dti-1400	6	72	72.7	72.7	NUM
dti-1400	6	73	to	to	ADP
dti-1400	6	74	59.5	59.5	NUM
dti-1400	6	75	ml	ml	NOUN
dti-1400	6	76	/	/	SYM
dti-1400	6	77	min	min	NOUN
dti-1400	6	78	and	and	CCONJ
dti-1400	6	79	78.9	78.9	NUM
dti-1400	6	80	to	to	ADP
dti-1400	6	81	64.7	64.7	NUM
dti-1400	6	82	ml	ml	NOUN
dti-1400	6	83	/	/	SYM
dti-1400	6	84	min/1.73	min/1.73	NOUN
dti-1400	6	85	m2	m2	PROPN
dti-1400	6	86	,	,	PUNCT
dti-1400	6	87	respectively	respectively	ADV
dti-1400	6	88	.	.	PUNCT
dti-1400	7	1	eight	eight	NUM
dti-1400	7	2	days	day	NOUN
dti-1400	7	3	before	before	ADP
dti-1400	7	4	this	this	DET
dti-1400	7	5	admission	admission	NOUN
dti-1400	7	6	,	,	PUNCT
dti-1400	7	7	she	she	PRON
dti-1400	7	8	had	have	AUX
dti-1400	7	9	noticed	notice	VERB
dti-1400	7	10	a	a	DET
dti-1400	7	11	maculopapular	maculopapular	ADJ
dti-1400	7	12	rash	rash	NOUN
dti-1400	7	13	over	over	ADP
dti-1400	7	14	the	the	DET
dti-1400	7	15	left	left	ADJ
dti-1400	7	16	ear	ear	NOUN
dti-1400	7	17	and	and	CCONJ
dti-1400	7	18	been	be	AUX
dti-1400	7	19	empirically	empirically	ADV
dti-1400	7	20	treated	treat	VERB
dti-1400	7	21	with	with	ADP
dti-1400	7	22	oral	oral	ADJ
dti-1400	7	23	cefcapene	cefcapene	ADJ
dti-1400	7	24	pivoxil	pivoxil	NOUN
dti-1400	7	25	hydrochloride	hydrochloride	NOUN
dti-1400	7	26	300	300	NUM
dti-1400	7	27	mg	mg	NUM
dti-1400	7	28	/	/	SYM
dti-1400	7	29	day	day	NOUN
dti-1400	7	30	combined	combine	VERB
dti-1400	7	31	with	with	ADP
dti-1400	7	32	topical	topical	ADJ
dti-1400	7	33	gentamicin	gentamicin	NOUN
dti-1400	7	34	by	by	ADP
dti-1400	7	35	her	her	PRON
dti-1400	7	36	general	general	ADJ
dti-1400	7	37	practitioner	practitioner	NOUN
dti-1400	7	38	.	.	PUNCT
dti-1400	8	1	three	three	NUM
dti-1400	8	2	days	day	NOUN
dti-1400	8	3	later	later	ADV
dti-1400	8	4	,	,	PUNCT
dti-1400	8	5	the	the	DET
dti-1400	8	6	rash	rash	NOUN
dti-1400	8	7	had	have	AUX
dti-1400	8	8	progressed	progress	VERB
dti-1400	8	9	to	to	ADP
dti-1400	8	10	clusters	cluster	NOUN
dti-1400	8	11	of	of	ADP
dti-1400	8	12	clear	clear	ADJ
dti-1400	8	13	vesicles	vesicle	NOUN
dti-1400	8	14	.	.	PUNCT
dti-1400	9	1	she	she	PRON
dti-1400	9	2	was	be	AUX
dti-1400	9	3	then	then	ADV
dti-1400	9	4	diagnosed	diagnose	VERB
dti-1400	9	5	with	with	ADP
dti-1400	9	6	left	left	ADJ
dti-1400	9	7	trigeminal	trigeminal	PROPN
dti-1400	9	8	hz	hz	VERB
dti-1400	9	9	and	and	CCONJ
dti-1400	9	10	subjected	subject	VERB
dti-1400	9	11	to	to	ADP
dti-1400	9	12	oral	oral	ADJ
dti-1400	9	13	valacyclovir	valacyclovir	NOUN
dti-1400	9	14	1	1	NUM
dti-1400	9	15	g	g	NOUN
dti-1400	9	16	three	three	NUM
dti-1400	9	17	times	time	NOUN
dti-1400	9	18	a	a	DET
dti-1400	9	19	day	day	NOUN
dti-1400	9	20	.	.	PUNCT
dti-1400	10	1	on	on	ADP
dti-1400	10	2	the	the	DET
dti-1400	10	3	fifth	fifth	ADJ
dti-1400	10	4	day	day	NOUN
dti-1400	10	5	of	of	ADP
dti-1400	10	6	the	the	DET
dti-1400	10	7	valacyclovir	valacyclovir	PROPN
dti-1400	10	8	treatment	treatment	NOUN
dti-1400	10	9	,	,	PUNCT
dti-1400	10	10	the	the	DET
dti-1400	10	11	patient	patient	NOUN
dti-1400	10	12	started	start	VERB
dti-1400	10	13	to	to	PART
dti-1400	10	14	exhibit	exhibit	VERB
dti-1400	10	15	mild	mild	ADJ
dti-1400	10	16	dysarthria	dysarthria	NOUN
dti-1400	10	17	characterized	characterize	VERB
dti-1400	10	18	by	by	ADP
dti-1400	10	19	slurred	slurred	ADJ
dti-1400	10	20	speech	speech	NOUN
dti-1400	10	21	followed	follow	VERB
dti-1400	10	22	by	by	ADP
dti-1400	10	23	a	a	DET
dti-1400	10	24	progressive	progressive	ADJ
dti-1400	10	25	deterioration	deterioration	NOUN
dti-1400	10	26	of	of	ADP
dti-1400	10	27	consciousness	consciousness	NOUN
dti-1400	10	28	.	.	PUNCT
dti-1400	11	1	the	the	DET
dti-1400	11	2	next	next	ADJ
dti-1400	11	3	day	day	NOUN
dti-1400	11	4	,	,	PUNCT
dti-1400	11	5	she	she	PRON
dti-1400	11	6	was	be	AUX
dti-1400	11	7	brought	bring	VERB
dti-1400	11	8	to	to	ADP
dti-1400	11	9	another	another	DET
dti-1400	11	10	emergency	emergency	NOUN
dti-1400	11	11	hospital	hospital	NOUN
dti-1400	11	12	by	by	ADP
dti-1400	11	13	her	her	PRON
dti-1400	11	14	son	son	NOUN
dti-1400	11	15	.	.	PUNCT
dti-1400	12	1	a	a	DET
dti-1400	12	2	physical	physical	ADJ
dti-1400	12	3	examination	examination	NOUN
dti-1400	12	4	revealed	reveal	VERB
dti-1400	12	5	her	she	PRON
dti-1400	12	6	to	to	PART
dti-1400	12	7	be	be	AUX
dti-1400	12	8	stuporous	stuporous	ADJ
dti-1400	12	9	and	and	CCONJ
dti-1400	12	10	afebrile	afebrile	ADJ
dti-1400	12	11	without	without	ADP
dti-1400	12	12	any	any	DET
dti-1400	12	13	facial	facial	ADJ
dti-1400	12	14	drooping	drooping	NOUN
dti-1400	12	15	,	,	PUNCT
dti-1400	12	16	tongue	tongue	NOUN
dti-1400	12	17	deviation	deviation	NOUN
dti-1400	12	18	,	,	PUNCT
dti-1400	12	19	hemiparesis	hemiparesis	NOUN
dti-1400	12	20	,	,	PUNCT
dti-1400	12	21	or	or	CCONJ
dti-1400	12	22	quadriparesis	quadriparesis	NOUN
dti-1400	12	23	.	.	PUNCT
dti-1400	13	1	diagnostic	diagnostic	ADJ
dti-1400	13	2	brain	brain	NOUN
dti-1400	13	3	computed	compute	VERB
dti-1400	13	4	tomography	tomography	NOUN
dti-1400	13	5	and	and	CCONJ
dti-1400	13	6	magnetic	magnetic	ADJ
dti-1400	13	7	resonance	resonance	NOUN
dti-1400	13	8	imaging	imaging	NOUN
dti-1400	13	9	revealed	reveal	VERB
dti-1400	13	10	no	no	DET
dti-1400	13	11	remarkable	remarkable	ADJ
dti-1400	13	12	abnormalities	abnormality	NOUN
dti-1400	13	13	,	,	PUNCT
dti-1400	13	14	whereas	whereas	SCONJ
dti-1400	13	15	a	a	DET
dti-1400	13	16	laboratory	laboratory	NOUN
dti-1400	13	17	analysis	analysis	NOUN
dti-1400	13	18	revealed	reveal	VERB
dti-1400	13	19	the	the	DET
dti-1400	13	20	elevated	elevated	ADJ
dti-1400	13	21	levels	level	NOUN
dti-1400	13	22	of	of	ADP
dti-1400	13	23	scr	scr	NOUN
dti-1400	13	24	of	of	ADP
dti-1400	13	25	7.44	7.44	NUM
dti-1400	13	26	mg	mg	PROPN
dti-1400	13	27	/	/	SYM
dti-1400	13	28	dl	dl	PROPN
dti-1400	13	29	and	and	CCONJ
dti-1400	13	30	valacyclovir	valacyclovir	PROPN
dti-1400	13	31	neurotoxicity	neurotoxicity	NOUN
dti-1400	13	32	and	and	CCONJ
dti-1400	13	33	nephrotoxicity	nephrotoxicity	NOUN
dti-1400	13	34	in	in	ADP
dti-1400	13	35	an	an	DET
dti-1400	13	36	elderly	elderly	ADJ
dti-1400	13	37	patient	patient	NOUN
dti-1400	13	38	complicated	complicate	VERB
dti-1400	13	39	by	by	ADP
dti-1400	13	40	hyponatremia	hyponatremia	PROPN
dti-1400	13	41	takuya	takuya	PROPN
dti-1400	13	42	murakami	murakami	PROPN
dti-1400	13	43	,	,	PUNCT
dti-1400	13	44	tetsu	tetsu	PROPN
dti-1400	13	45	akimoto	akimoto	PROPN
dti-1400	13	46	,	,	PUNCT
dti-1400	13	47	mari	mari	PROPN
dti-1400	13	48	okada	okada	PROPN
dti-1400	13	49	,	,	PUNCT
dti-1400	13	50	erika	erika	PROPN
dti-1400	13	51	hishida	hishida	PROPN
dti-1400	13	52	,	,	PUNCT
dti-1400	13	53	taro	taro	NOUN
dti-1400	13	54	sugase	sugase	NOUN
dti-1400	13	55	,	,	PUNCT
dti-1400	13	56	atsushi	atsushi	PROPN
dti-1400	13	57	miki	miki	PROPN
dti-1400	13	58	,	,	PUNCT
dti-1400	13	59	marina	marina	PROPN
dti-1400	13	60	kohara	kohara	PROPN
dti-1400	13	61	,	,	PUNCT
dti-1400	13	62	hiromichi	hiromichi	PROPN
dti-1400	13	63	yoshizawa	yoshizawa	PROPN
dti-1400	13	64	,	,	PUNCT
dti-1400	13	65	takahiro	takahiro	PROPN
dti-1400	13	66	masuda	masuda	PROPN
dti-1400	13	67	,	,	PUNCT
dti-1400	13	68	takahisa	takahisa	PROPN
dti-1400	13	69	kobayashi	kobayashi	PROPN
dti-1400	13	70	,	,	PUNCT
dti-1400	13	71	osamu	osamu	PROPN
dti-1400	13	72	saito	saito	PROPN
dti-1400	13	73	,	,	PUNCT
dti-1400	13	74	shigeaki	shigeaki	PROPN
dti-1400	13	75	muto	muto	PROPN
dti-1400	13	76	and	and	CCONJ
dti-1400	13	77	daisuke	daisuke	PROPN
dti-1400	13	78	nagata	nagata	PROPN
dti-1400	13	79	division	division	NOUN
dti-1400	13	80	of	of	ADP
dti-1400	13	81	nephrology	nephrology	NOUN
dti-1400	13	82	,	,	PUNCT
dti-1400	13	83	department	department	NOUN
dti-1400	13	84	of	of	ADP
dti-1400	13	85	internal	internal	ADJ
dti-1400	13	86	medicine	medicine	NOUN
dti-1400	13	87	,	,	PUNCT
dti-1400	13	88	jichi	jichi	PROPN
dti-1400	13	89	medical	medical	PROPN
dti-1400	13	90	university	university	PROPN
dti-1400	13	91	,	,	PUNCT
dti-1400	13	92	shimotsuke	shimotsuke	PROPN
dti-1400	13	93	,	,	PUNCT
dti-1400	13	94	japan	japan	PROPN
dti-1400	13	95	.	.	PUNCT
dti-1400	14	1	abstract	abstract	PROPN
dti-1400	14	2	:	:	PUNCT
dti-1400	14	3	a	a	DET
dti-1400	14	4	66	66	NUM
dti-1400	14	5	-	-	PUNCT
dti-1400	14	6	year	year	NOUN
dti-1400	14	7	-	-	PUNCT
dti-1400	14	8	old	old	ADJ
dti-1400	14	9	women	woman	NOUN
dti-1400	14	10	with	with	ADP
dti-1400	14	11	no	no	DET
dti-1400	14	12	history	history	NOUN
dti-1400	14	13	of	of	ADP
dti-1400	14	14	renal	renal	ADJ
dti-1400	14	15	disease	disease	NOUN
dti-1400	14	16	was	be	AUX
dti-1400	14	17	admitted	admit	VERB
dti-1400	14	18	due	due	ADP
dti-1400	14	19	to	to	ADP
dti-1400	14	20	a	a	DET
dti-1400	14	21	coma	coma	NOUN
dti-1400	14	22	and	and	CCONJ
dti-1400	14	23	acute	acute	ADJ
dti-1400	14	24	kidney	kidney	NOUN
dti-1400	14	25	injury	injury	NOUN
dti-1400	14	26	with	with	ADP
dti-1400	14	27	a	a	DET
dti-1400	14	28	serum	serum	NOUN
dti-1400	14	29	creatinine	creatinine	NOUN
dti-1400	14	30	level	level	NOUN
dti-1400	14	31	of	of	ADP
dti-1400	14	32	7.44	7.44	NUM
dti-1400	14	33	mg	mg	PROPN
dti-1400	14	34	/	/	SYM
dti-1400	14	35	dl	dl	PROPN
dti-1400	14	36	which	which	PRON
dti-1400	14	37	were	be	AUX
dti-1400	14	38	ascribed	ascribe	VERB
dti-1400	14	39	to	to	ADP
dti-1400	14	40	valacyclovir	valacyclovir	PROPN
dti-1400	14	41	neurotoxicity	neurotoxicity	NOUN
dti-1400	14	42	and	and	CCONJ
dti-1400	14	43	nephrotoxicity	nephrotoxicity	NOUN
dti-1400	14	44	,	,	PUNCT
dti-1400	14	45	respectively	respectively	ADV
dti-1400	14	46	.	.	PUNCT
dti-1400	15	1	she	she	PRON
dti-1400	15	2	had	have	AUX
dti-1400	15	3	received	receive	VERB
dti-1400	15	4	valacyclovir	valacyclovir	NOUN
dti-1400	15	5	at	at	ADP
dti-1400	15	6	a	a	DET
dti-1400	15	7	standard	standard	ADJ
dti-1400	15	8	dosage	dosage	NOUN
dti-1400	15	9	for	for	ADP
dti-1400	15	10	the	the	DET
dti-1400	15	11	treatment	treatment	NOUN
dti-1400	15	12	of	of	ADP
dti-1400	15	13	herpes	herpe	NOUN
dti-1400	15	14	zoster	zoster	NOUN
dti-1400	15	15	and	and	CCONJ
dti-1400	15	16	was	be	AUX
dti-1400	15	17	finally	finally	ADV
dti-1400	15	18	discharged	discharge	VERB
dti-1400	15	19	,	,	PUNCT
dti-1400	15	20	having	having	AUX
dti-1400	15	21	fully	fully	ADV
dti-1400	15	22	returned	return	VERB
dti-1400	15	23	to	to	ADP
dti-1400	15	24	her	her	PRON
dti-1400	15	25	normal	normal	ADJ
dti-1400	15	26	baseline	baseline	ADJ
dti-1400	15	27	mental	mental	ADJ
dti-1400	15	28	status	status	NOUN
dti-1400	15	29	with	with	ADP
dti-1400	15	30	a	a	DET
dti-1400	15	31	recovered	recover	VERB
dti-1400	15	32	serum	serum	NOUN
dti-1400	15	33	creatinine	creatinine	NOUN
dti-1400	15	34	level	level	NOUN
dti-1400	15	35	of	of	ADP
dti-1400	15	36	0.68	0.68	NUM
dti-1400	15	37	mg	mg	PROPN
dti-1400	15	38	/	/	SYM
dti-1400	15	39	dl	dl	PROPN
dti-1400	15	40	.	.	PUNCT
dti-1400	16	1	we	we	PRON
dti-1400	16	2	feel	feel	VERB
dti-1400	16	3	that	that	SCONJ
dti-1400	16	4	awareness	awareness	NOUN
dti-1400	16	5	of	of	ADP
dti-1400	16	6	this	this	DET
dti-1400	16	7	pathology	pathology	NOUN
dti-1400	16	8	remains	remain	VERB
dti-1400	16	9	a	a	DET
dti-1400	16	10	challenge	challenge	NOUN
dti-1400	16	11	for	for	ADP
dti-1400	16	12	physicians	physician	NOUN
dti-1400	16	13	and	and	CCONJ
dti-1400	16	14	therefore	therefore	ADV
dti-1400	16	15	strongly	strongly	ADV
dti-1400	16	16	recommend	recommend	VERB
dti-1400	16	17	the	the	DET
dti-1400	16	18	further	further	ADJ
dti-1400	16	19	accumulation	accumulation	NOUN
dti-1400	16	20	of	of	ADP
dti-1400	16	21	experiences	experience	NOUN
dti-1400	16	22	similar	similar	ADJ
dti-1400	16	23	to	to	ADP
dti-1400	16	24	our	our	PRON
dti-1400	16	25	own	own	ADJ
dti-1400	16	26	.	.	PUNCT
dti-1400	17	1	our	our	PRON
dti-1400	17	2	experience	experience	NOUN
dti-1400	17	3	underscores	underscore	VERB
dti-1400	17	4	the	the	DET
dti-1400	17	5	pitfalls	pitfall	NOUN
dti-1400	17	6	of	of	ADP
dti-1400	17	7	administering	administer	VERB
dti-1400	17	8	valacyclovir	valacyclovir	NOUN
dti-1400	17	9	to	to	ADP
dti-1400	17	10	elderly	elderly	ADJ
dti-1400	17	11	patients	patient	NOUN
dti-1400	17	12	who	who	PRON
dti-1400	17	13	barely	barely	ADV
dti-1400	17	14	appear	appear	VERB
dti-1400	17	15	to	to	PART
dti-1400	17	16	have	have	VERB
dti-1400	17	17	a	a	DET
dti-1400	17	18	favorable	favorable	ADJ
dti-1400	17	19	renal	renal	ADJ
dti-1400	17	20	function	function	NOUN
dti-1400	17	21	.	.	PUNCT
dti-1400	18	1	several	several	ADJ
dti-1400	18	2	concerns	concern	NOUN
dti-1400	18	3	regarding	regard	VERB
dti-1400	18	4	the	the	DET
dti-1400	18	5	therapeutic	therapeutic	ADJ
dti-1400	18	6	management	management	NOUN
dti-1400	18	7	,	,	PUNCT
dti-1400	18	8	including	include	VERB
dti-1400	18	9	blood	blood	NOUN
dti-1400	18	10	purification	purification	NOUN
dti-1400	18	11	strategies	strategy	NOUN
dti-1400	18	12	,	,	PUNCT
dti-1400	18	13	that	that	PRON
dti-1400	18	14	emerged	emerge	VERB
dti-1400	18	15	in	in	ADP
dti-1400	18	16	this	this	DET
dti-1400	18	17	case	case	NOUN
dti-1400	18	18	are	be	AUX
dti-1400	18	19	also	also	ADV
dti-1400	18	20	discussed	discuss	VERB
dti-1400	18	21	.	.	PUNCT
dti-1400	19	1	keywords	keyword	NOUN
dti-1400	19	2	:	:	PUNCT
dti-1400	19	3	valacyclovir	valacyclovir	PROPN
dti-1400	19	4	neurotoxicity	neurotoxicity	NOUN
dti-1400	19	5	,	,	PUNCT
dti-1400	19	6	acute	acute	ADJ
dti-1400	19	7	kidney	kidney	NOUN
dti-1400	19	8	injury	injury	NOUN
dti-1400	19	9	,	,	PUNCT
dti-1400	19	10	hemodialysis	hemodialysis	NOUN
dti-1400	19	11	,	,	PUNCT
dti-1400	19	12	hyponatremia	hyponatremia	PROPN
dti-1400	19	13	,	,	PUNCT
dti-1400	19	14	osmotic	osmotic	ADJ
dti-1400	19	15	demyelination	demyelination	NOUN
dti-1400	19	16	syndrome	syndrome	NOUN
dti-1400	19	17	received	receive	VERB
dti-1400	19	18	:	:	PUNCT
dti-1400	19	19	january	january	PROPN
dti-1400	19	20	28	28	NUM
dti-1400	19	21	,	,	PUNCT
dti-1400	19	22	2018	2018	NUM
dti-1400	19	23	.	.	PUNCT
dti-1400	20	1	accepted	accept	VERB
dti-1400	20	2	:	:	PUNCT
dti-1400	20	3	may	may	AUX
dti-1400	20	4	16	16	NUM
dti-1400	20	5	,	,	PUNCT
dti-1400	20	6	2018	2018	NUM
dti-1400	20	7	.	.	PUNCT
dti-1400	21	1	type	type	NOUN
dti-1400	21	2	:	:	PUNCT
dti-1400	21	3	case	case	NOUN
dti-1400	21	4	report	report	NOUN
dti-1400	21	5	funding	funding	NOUN
dti-1400	21	6	:	:	PUNCT
dti-1400	21	7	the	the	DET
dti-1400	21	8	author(s	author(s	PROPN
dti-1400	21	9	)	)	PUNCT
dti-1400	21	10	disclosed	disclose	VERB
dti-1400	21	11	receipt	receipt	NOUN
dti-1400	21	12	of	of	ADP
dti-1400	21	13	the	the	DET
dti-1400	21	14	following	follow	VERB
dti-1400	21	15	financial	financial	ADJ
dti-1400	21	16	support	support	NOUN
dti-1400	21	17	for	for	ADP
dti-1400	21	18	the	the	DET
dti-1400	21	19	research	research	NOUN
dti-1400	21	20	,	,	PUNCT
dti-1400	21	21	authorship	authorship	NOUN
dti-1400	21	22	,	,	PUNCT
dti-1400	21	23	and/or	and/or	CCONJ
dti-1400	21	24	publication	publication	NOUN
dti-1400	21	25	of	of	ADP
dti-1400	21	26	this	this	DET
dti-1400	21	27	article	article	NOUN
dti-1400	21	28	:	:	PUNCT
dti-1400	21	29	this	this	DET
dti-1400	21	30	study	study	NOUN
dti-1400	21	31	was	be	AUX
dti-1400	21	32	supported	support	VERB
dti-1400	21	33	in	in	ADP
dti-1400	21	34	part	part	NOUN
dti-1400	21	35	by	by	ADP
dti-1400	21	36	a	a	DET
dti-1400	21	37	grant	grant	NOUN
dti-1400	21	38	-	-	PUNCT
dti-1400	21	39	in	in	ADP
dti-1400	21	40	-	-	PUNCT
dti-1400	21	41	aid	aid	NOUN
dti-1400	21	42	for	for	ADP
dti-1400	21	43	research	research	NOUN
dti-1400	21	44	on	on	ADP
dti-1400	21	45	advanced	advanced	ADJ
dti-1400	21	46	chronic	chronic	ADJ
dti-1400	21	47	kidney	kidney	NOUN
dti-1400	21	48	disease	disease	NOUN
dti-1400	21	49	,	,	PUNCT
dti-1400	21	50	practical	practical	ADJ
dti-1400	21	51	research	research	NOUN
dti-1400	21	52	project	project	NOUN
dti-1400	21	53	for	for	ADP
dti-1400	21	54	renal	renal	ADJ
dti-1400	21	55	diseases	disease	NOUN
dti-1400	21	56	from	from	ADP
dti-1400	21	57	the	the	DET
dti-1400	21	58	japan	japan	PROPN
dti-1400	21	59	agency	agency	PROPN
dti-1400	21	60	for	for	ADP
dti-1400	21	61	medical	medical	ADJ
dti-1400	21	62	research	research	NOUN
dti-1400	21	63	and	and	CCONJ
dti-1400	21	64	development	development	NOUN
dti-1400	21	65	(	(	PUNCT
dti-1400	21	66	amed	amed	PROPN
dti-1400	21	67	)	)	PUNCT
dti-1400	21	68	,	,	PUNCT
dti-1400	21	69	and	and	CCONJ
dti-1400	21	70	by	by	ADP
dti-1400	21	71	a	a	DET
dti-1400	21	72	grant	grant	NOUN
dti-1400	21	73	for	for	ADP
dti-1400	21	74	private	private	ADJ
dti-1400	21	75	university	university	NOUN
dti-1400	21	76	research	research	NOUN
dti-1400	21	77	branding	branding	NOUN
dti-1400	21	78	project	project	NOUN
dti-1400	21	79	from	from	ADP
dti-1400	21	80	the	the	DET
dti-1400	21	81	ministry	ministry	PROPN
dti-1400	21	82	of	of	ADP
dti-1400	21	83	education	education	PROPN
dti-1400	21	84	,	,	PUNCT
dti-1400	21	85	science	science	NOUN
dti-1400	21	86	and	and	CCONJ
dti-1400	21	87	culture	culture	NOUN
dti-1400	21	88	,	,	PUNCT
dti-1400	21	89	japan	japan	PROPN
dti-1400	21	90	.	.	PUNCT
dti-1400	22	1	declaration	declaration	NOUN
dti-1400	22	2	of	of	ADP
dti-1400	22	3	conflicting	conflicting	ADJ
dti-1400	22	4	interests	interest	NOUN
dti-1400	22	5	:	:	PUNCT
dti-1400	22	6	the	the	DET
dti-1400	22	7	author(s	author(s	NOUN
dti-1400	22	8	)	)	PUNCT
dti-1400	22	9	declared	declare	VERB
dti-1400	22	10	no	no	DET
dti-1400	22	11	potential	potential	ADJ
dti-1400	22	12	conflicts	conflict	NOUN
dti-1400	22	13	of	of	ADP
dti-1400	22	14	interest	interest	NOUN
dti-1400	22	15	with	with	ADP
dti-1400	22	16	respect	respect	NOUN
dti-1400	22	17	to	to	ADP
dti-1400	22	18	the	the	DET
dti-1400	22	19	research	research	NOUN
dti-1400	22	20	,	,	PUNCT
dti-1400	22	21	authorship	authorship	NOUN
dti-1400	22	22	,	,	PUNCT
dti-1400	22	23	and/or	and/or	CCONJ
dti-1400	22	24	publication	publication	NOUN
dti-1400	22	25	of	of	ADP
dti-1400	22	26	this	this	DET
dti-1400	22	27	article	article	NOUN
dti-1400	22	28	.	.	PUNCT
dti-1400	23	1	corresponding	correspond	VERB
dti-1400	23	2	author	author	NOUN
dti-1400	23	3	:	:	PUNCT
dti-1400	23	4	tetsu	tetsu	PROPN
dti-1400	23	5	akimoto	akimoto	PROPN
dti-1400	23	6	,	,	PUNCT
dti-1400	23	7	division	division	NOUN
dti-1400	23	8	of	of	ADP
dti-1400	23	9	nephrology	nephrology	NOUN
dti-1400	23	10	,	,	PUNCT
dti-1400	23	11	department	department	NOUN
dti-1400	23	12	of	of	ADP
dti-1400	23	13	internal	internal	ADJ
dti-1400	23	14	medicine	medicine	NOUN
dti-1400	23	15	,	,	PUNCT
dti-1400	23	16	jichi	jichi	PROPN
dti-1400	23	17	medical	medical	PROPN
dti-1400	23	18	university	university	PROPN
dti-1400	23	19	,	,	PUNCT
dti-1400	23	20	3311	3311	NUM
dti-1400	23	21	-	-	SYM
dti-1400	23	22	1	1	NUM
dti-1400	23	23	yakushiji	yakushiji	NOUN
dti-1400	23	24	,	,	PUNCT
dti-1400	23	25	shimotsuke	shimotsuke	NOUN
dti-1400	23	26	-	-	PUNCT
dti-1400	23	27	shi	shi	PROPN
dti-1400	23	28	329	329	NUM
dti-1400	23	29	-	-	SYM
dti-1400	23	30	0498	0498	NUM
dti-1400	23	31	,	,	PUNCT
dti-1400	23	32	tochigi	tochigi	PROPN
dti-1400	23	33	,	,	PUNCT
dti-1400	23	34	japan	japan	PROPN
dti-1400	23	35	.	.	PUNCT
dti-1400	24	1	email	email	NOUN
dti-1400	24	2	:	:	PUNCT
dti-1400	24	3	tetsu-a@jichi.ac.jp	tetsu-a@jichi.ac.jp	ADJ
dti-1400	24	4	782899	782899	NUM
dti-1400	24	5	dti0010.1177/1177392818782899drug	dti0010.1177/1177392818782899drug	PROPN
dti-1400	24	6	target	target	NOUN
dti-1400	24	7	insightsmurakami	insightsmurakami	NOUN
dti-1400	24	8	et	et	PROPN
dti-1400	24	9	al	al	PROPN
dti-1400	24	10	case	case	NOUN
dti-1400	24	11	-	-	PUNCT
dti-1400	24	12	report2018	report2018	NOUN
dti-1400	24	13	https://uk.sagepub.com/en-gb/journals-permissions	https://uk.sagepub.com/en-gb/journals-permission	NOUN
dti-1400	24	14	mailto:tetsu-a@jichi.ac.jp	mailto:tetsu-a@jichi.ac.jp	ADJ
dti-1400	24	15	2	2	NUM
dti-1400	24	16	drug	drug	NOUN
dti-1400	24	17	target	target	NOUN
dti-1400	24	18	insights	insight	NOUN
dti-1400	24	19	serum	serum	VERB
dti-1400	24	20	potassium	potassium	NOUN
dti-1400	24	21	of	of	ADP
dti-1400	24	22	6.2	6.2	NUM
dti-1400	24	23	mmol	mmol	NOUN
dti-1400	24	24	/	/	SYM
dti-1400	24	25	l.	l.	PROPN
dti-1400	24	26	she	she	PRON
dti-1400	24	27	was	be	AUX
dti-1400	24	28	empirically	empirically	ADV
dti-1400	24	29	given	give	VERB
dti-1400	24	30	10	10	NUM
dti-1400	24	31	mg	mg	ADP
dti-1400	24	32	of	of	ADP
dti-1400	24	33	furosemide	furosemide	ADV
dti-1400	24	34	as	as	ADV
dti-1400	24	35	well	well	ADV
dti-1400	24	36	as	as	ADP
dti-1400	24	37	10	10	NUM
dti-1400	24	38	ml	ml	NOUN
dti-1400	24	39	of	of	ADP
dti-1400	24	40	8.5	8.5	NUM
dti-1400	24	41	%	%	NOUN
dti-1400	24	42	calcium	calcium	NOUN
dti-1400	24	43	gluconate	gluconate	NOUN
dti-1400	24	44	intravenously	intravenously	ADV
dti-1400	24	45	and	and	CCONJ
dti-1400	24	46	then	then	ADV
dti-1400	24	47	transferred	transfer	VERB
dti-1400	24	48	and	and	CCONJ
dti-1400	24	49	admitted	admit	VERB
dti-1400	24	50	to	to	ADP
dti-1400	24	51	our	our	PRON
dti-1400	24	52	hospital	hospital	NOUN
dti-1400	24	53	for	for	ADP
dti-1400	24	54	further	further	ADJ
dti-1400	24	55	work	work	NOUN
dti-1400	24	56	-	-	PUNCT
dti-1400	24	57	up	up	NOUN
dti-1400	24	58	.	.	PUNCT
dti-1400	25	1	on	on	ADP
dti-1400	25	2	admission	admission	NOUN
dti-1400	25	3	,	,	PUNCT
dti-1400	25	4	the	the	DET
dti-1400	25	5	patient	patient	NOUN
dti-1400	25	6	had	have	VERB
dti-1400	25	7	a	a	DET
dti-1400	25	8	blood	blood	NOUN
dti-1400	25	9	pressure	pressure	NOUN
dti-1400	25	10	of	of	ADP
dti-1400	25	11	191/105	191/105	NUM
dti-1400	25	12	mm	mm	PROPN
dti-1400	25	13	hg	hg	NOUN
dti-1400	25	14	with	with	ADP
dti-1400	25	15	a	a	DET
dti-1400	25	16	pulse	pulse	NOUN
dti-1400	25	17	of	of	ADP
dti-1400	25	18	101	101	NUM
dti-1400	25	19	beats	beat	NOUN
dti-1400	25	20	/	/	SYM
dti-1400	25	21	min	min	NOUN
dti-1400	25	22	.	.	PROPN
dti-1400	26	1	she	she	PRON
dti-1400	26	2	was	be	AUX
dti-1400	26	3	a	a	DET
dti-1400	26	4	wellnourished	wellnourished	ADJ
dti-1400	26	5	woman	woman	NOUN
dti-1400	26	6	of	of	ADP
dti-1400	26	7	152	152	NUM
dti-1400	26	8	cm	cm	NOUN
dti-1400	26	9	in	in	ADP
dti-1400	26	10	height	height	NOUN
dti-1400	26	11	and	and	CCONJ
dti-1400	26	12	47.4	47.4	NUM
dti-1400	26	13	kg	kg	NOUN
dti-1400	26	14	in	in	ADP
dti-1400	26	15	weight	weight	NOUN
dti-1400	26	16	.	.	PUNCT
dti-1400	27	1	her	her	PRON
dti-1400	27	2	consciousness	consciousness	NOUN
dti-1400	27	3	level	level	NOUN
dti-1400	27	4	was	be	AUX
dti-1400	27	5	e3v4m6	e3v4m6	NOUN
dti-1400	27	6	on	on	ADP
dti-1400	27	7	the	the	DET
dti-1400	27	8	glasgow	glasgow	ADJ
dti-1400	27	9	coma	coma	NOUN
dti-1400	27	10	scale	scale	NOUN
dti-1400	27	11	(	(	PUNCT
dti-1400	27	12	gcs	gcs	PROPN
dti-1400	27	13	)	)	PUNCT
dti-1400	27	14	.	.	PUNCT
dti-1400	28	1	renal	renal	ADJ
dti-1400	28	2	sonography	sonography	NOUN
dti-1400	28	3	on	on	ADP
dti-1400	28	4	both	both	DET
dti-1400	28	5	kidneys	kidney	NOUN
dti-1400	28	6	revealed	reveal	VERB
dti-1400	28	7	preservation	preservation	NOUN
dti-1400	28	8	of	of	ADP
dti-1400	28	9	the	the	DET
dti-1400	28	10	size	size	NOUN
dti-1400	28	11	with	with	ADP
dti-1400	28	12	normal	normal	ADJ
dti-1400	28	13	renal	renal	ADJ
dti-1400	28	14	cortex	cortex	NOUN
dti-1400	28	15	echogenicity	echogenicity	NOUN
dti-1400	28	16	.	.	PUNCT
dti-1400	29	1	a	a	DET
dti-1400	29	2	laboratory	laboratory	NOUN
dti-1400	29	3	examination	examination	NOUN
dti-1400	29	4	revealed	reveal	VERB
dti-1400	29	5	the	the	DET
dti-1400	29	6	following	follow	VERB
dti-1400	29	7	results	result	NOUN
dti-1400	29	8	:	:	PUNCT
dti-1400	29	9	hemoglobin	hemoglobin	NOUN
dti-1400	29	10	,	,	PUNCT
dti-1400	29	11	11.9	11.9	NUM
dti-1400	29	12	g	g	NOUN
dti-1400	29	13	/	/	SYM
dti-1400	29	14	dl	dl	PROPN
dti-1400	29	15	;	;	PUNCT
dti-1400	29	16	hematocrit	hematocrit	ADJ
dti-1400	29	17	,	,	PUNCT
dti-1400	29	18	36.9	36.9	NUM
dti-1400	29	19	%	%	NOUN
dti-1400	29	20	;	;	PUNCT
dti-1400	29	21	platelet	platelet	NOUN
dti-1400	29	22	count	count	NOUN
dti-1400	29	23	,	,	PUNCT
dti-1400	29	24	15.9	15.9	NUM
dti-1400	29	25	×	×	NOUN
dti-1400	29	26	104	104	NUM
dti-1400	29	27	/	/	SYM
dti-1400	29	28	μl	μl	PRON
dti-1400	29	29	;	;	PUNCT
dti-1400	29	30	blood	blood	NOUN
dti-1400	29	31	urea	urea	NOUN
dti-1400	29	32	nitrogen	nitrogen	NOUN
dti-1400	29	33	,	,	PUNCT
dti-1400	29	34	53	53	NUM
dti-1400	29	35	mg	mg	PROPN
dti-1400	29	36	/	/	SYM
dti-1400	29	37	dl	dl	PROPN
dti-1400	29	38	;	;	PUNCT
dti-1400	29	39	scr	scr	NOUN
dti-1400	29	40	,	,	PUNCT
dti-1400	29	41	7.27	7.27	NUM
dti-1400	29	42	mg	mg	PROPN
dti-1400	29	43	/	/	SYM
dti-1400	29	44	dl	dl	PROPN
dti-1400	29	45	;	;	PUNCT
dti-1400	29	46	uric	uric	ADJ
dti-1400	29	47	acid	acid	NOUN
dti-1400	29	48	,	,	PUNCT
dti-1400	29	49	8.8	8.8	NUM
dti-1400	29	50	mg	mg	PROPN
dti-1400	29	51	/	/	SYM
dti-1400	29	52	dl	dl	PROPN
dti-1400	29	53	;	;	PUNCT
dti-1400	29	54	total	total	ADJ
dti-1400	29	55	protein	protein	NOUN
dti-1400	29	56	,	,	PUNCT
dti-1400	29	57	6.4	6.4	NUM
dti-1400	29	58	g	g	NOUN
dti-1400	29	59	/	/	SYM
dti-1400	29	60	dl	dl	PROPN
dti-1400	29	61	;	;	PUNCT
dti-1400	29	62	serum	serum	NOUN
dti-1400	29	63	albumin	albumin	NOUN
dti-1400	29	64	,	,	PUNCT
dti-1400	29	65	3.3	3.3	NUM
dti-1400	29	66	g	g	NOUN
dti-1400	29	67	/	/	SYM
dti-1400	29	68	dl	dl	PROPN
dti-1400	29	69	;	;	PUNCT
dti-1400	29	70	sodium	sodium	NOUN
dti-1400	29	71	,	,	PUNCT
dti-1400	29	72	122	122	NUM
dti-1400	29	73	mmol	mmol	NOUN
dti-1400	29	74	/	/	SYM
dti-1400	29	75	l	l	NOUN
dti-1400	29	76	;	;	PUNCT
dti-1400	29	77	potassium	potassium	NOUN
dti-1400	29	78	,	,	PUNCT
dti-1400	29	79	5.9	5.9	NUM
dti-1400	29	80	mmol	mmol	NOUN
dti-1400	29	81	/	/	SYM
dti-1400	29	82	l	l	NOUN
dti-1400	29	83	;	;	PUNCT
dti-1400	29	84	chloride	chloride	NOUN
dti-1400	29	85	,	,	PUNCT
dti-1400	29	86	92	92	NUM
dti-1400	29	87	mmol	mmol	NOUN
dti-1400	29	88	/	/	SYM
dti-1400	29	89	l	l	NOUN
dti-1400	29	90	;	;	PUNCT
dti-1400	29	91	ca	ca	PROPN
dti-1400	29	92	,	,	PUNCT
dti-1400	29	93	8.3	8.3	NUM
dti-1400	29	94	mg	mg	PROPN
dti-1400	29	95	/	/	SYM
dti-1400	29	96	dl	dl	PROPN
dti-1400	29	97	;	;	PUNCT
dti-1400	29	98	phosphorus	phosphorus	NOUN
dti-1400	29	99	,	,	PUNCT
dti-1400	29	100	5.0	5.0	NUM
dti-1400	29	101	mg	mg	PROPN
dti-1400	29	102	/	/	SYM
dti-1400	29	103	dl	dl	PROPN
dti-1400	29	104	;	;	PUNCT
dti-1400	29	105	c3	c3	PROPN
dti-1400	29	106	,	,	PUNCT
dti-1400	29	107	112	112	NUM
dti-1400	29	108	mg	mg	PROPN
dti-1400	29	109	/	/	SYM
dti-1400	29	110	dl	dl	PROPN
dti-1400	29	111	;	;	PUNCT
dti-1400	29	112	c4	c4	NOUN
dti-1400	29	113	,	,	PUNCT
dti-1400	29	114	25	25	NUM
dti-1400	29	115	mg	mg	PROPN
dti-1400	29	116	/	/	SYM
dti-1400	29	117	dl	dl	PROPN
dti-1400	29	118	;	;	PUNCT
dti-1400	29	119	immunoglobulin	immunoglobulin	NOUN
dti-1400	29	120	(	(	PUNCT
dti-1400	29	121	ig	ig	PROPN
dti-1400	29	122	)	)	PUNCT
dti-1400	29	123	g	g	NOUN
dti-1400	29	124	,	,	PUNCT
dti-1400	29	125	1246	1246	NUM
dti-1400	29	126	mg/	mg/	PROPN
dti-1400	29	127	dl	dl	PROPN
dti-1400	29	128	;	;	PUNCT
dti-1400	29	129	iga	iga	PROPN
dti-1400	29	130	,	,	PUNCT
dti-1400	29	131	239	239	NUM
dti-1400	29	132	mg	mg	PROPN
dti-1400	29	133	/	/	SYM
dti-1400	29	134	dl	dl	PROPN
dti-1400	29	135	;	;	PUNCT
dti-1400	29	136	and	and	CCONJ
dti-1400	29	137	igm	igm	PROPN
dti-1400	29	138	,	,	PUNCT
dti-1400	29	139	73	73	NUM
dti-1400	29	140	mg	mg	PROPN
dti-1400	29	141	/	/	SYM
dti-1400	29	142	dl	dl	PROPN
dti-1400	29	143	.	.	PROPN
dti-1400	30	1	a	a	DET
dti-1400	30	2	serological	serological	ADJ
dti-1400	30	3	study	study	NOUN
dti-1400	30	4	revealed	reveal	VERB
dti-1400	30	5	an	an	DET
dti-1400	30	6	increased	increased	ADJ
dti-1400	30	7	level	level	NOUN
dti-1400	30	8	of	of	ADP
dti-1400	30	9	c	c	NOUN
dti-1400	30	10	-	-	PUNCT
dti-1400	30	11	reactive	reactive	ADJ
dti-1400	30	12	protein	protein	NOUN
dti-1400	30	13	of	of	ADP
dti-1400	30	14	3.55	3.55	NUM
dti-1400	30	15	mg	mg	PROPN
dti-1400	30	16	/	/	SYM
dti-1400	30	17	dl	dl	PROPN
dti-1400	30	18	,	,	PUNCT
dti-1400	30	19	whereas	whereas	SCONJ
dti-1400	30	20	the	the	DET
dti-1400	30	21	patient	patient	NOUN
dti-1400	30	22	was	be	AUX
dti-1400	30	23	negative	negative	ADJ
dti-1400	30	24	for	for	ADP
dti-1400	30	25	antimyeloperoxidase	antimyeloperoxidase	NOUN
dti-1400	30	26	antineutrophil	antineutrophil	NOUN
dti-1400	30	27	cytoplasmic	cytoplasmic	ADJ
dti-1400	30	28	antibody	antibody	NOUN
dti-1400	30	29	(	(	PUNCT
dti-1400	30	30	anca	anca	NOUN
dti-1400	30	31	)	)	PUNCT
dti-1400	30	32	,	,	PUNCT
dti-1400	30	33	antiproteinase	antiproteinase	ADJ
dti-1400	30	34	3	3	NUM
dti-1400	30	35	-	-	PUNCT
dti-1400	30	36	anca	anca	NOUN
dti-1400	30	37	,	,	PUNCT
dti-1400	30	38	anti	anti	ADJ
dti-1400	30	39	-	-	ADJ
dti-1400	30	40	glomerular	glomerular	ADJ
dti-1400	30	41	basement	basement	NOUN
dti-1400	30	42	membrane	membrane	NOUN
dti-1400	30	43	antibodies	antibodie	VERB
dti-1400	30	44	,	,	PUNCT
dti-1400	30	45	and	and	CCONJ
dti-1400	30	46	anti	anti	ADJ
dti-1400	30	47	–	–	ADJ
dti-1400	30	48	double	double	ADJ
dti-1400	30	49	-	-	PUNCT
dti-1400	30	50	stranded	strand	VERB
dti-1400	30	51	dna	dna	NOUN
dti-1400	30	52	antibodies	antibodie	VERB
dti-1400	30	53	.	.	PUNCT
dti-1400	31	1	no	no	DET
dti-1400	31	2	serum	serum	NOUN
dti-1400	31	3	thyroidstimulating	thyroidstimulate	VERB
dti-1400	31	4	hormone	hormone	NOUN
dti-1400	31	5	abnormalities	abnormality	NOUN
dti-1400	31	6	were	be	AUX
dti-1400	31	7	found	find	VERB
dti-1400	31	8	.	.	PUNCT
dti-1400	32	1	a	a	DET
dti-1400	32	2	lumbar	lumbar	NOUN
dti-1400	32	3	puncture	puncture	NOUN
dti-1400	32	4	revealed	reveal	VERB
dti-1400	32	5	a	a	DET
dti-1400	32	6	protein	protein	NOUN
dti-1400	32	7	concentration	concentration	NOUN
dti-1400	32	8	of	of	ADP
dti-1400	32	9	54	54	NUM
dti-1400	32	10	mg	mg	PROPN
dti-1400	32	11	/	/	SYM
dti-1400	32	12	dl	dl	PROPN
dti-1400	32	13	and	and	CCONJ
dti-1400	32	14	glucose	glucose	VERB
dti-1400	32	15	concentration	concentration	NOUN
dti-1400	32	16	of	of	ADP
dti-1400	32	17	91	91	NUM
dti-1400	32	18	mg	mg	PROPN
dti-1400	32	19	/	/	SYM
dti-1400	32	20	dl	dl	PROPN
dti-1400	32	21	,	,	PUNCT
dti-1400	32	22	whereas	whereas	SCONJ
dti-1400	32	23	gram	gram	NOUN
dti-1400	32	24	staining	stain	VERB
dti-1400	32	25	failed	fail	VERB
dti-1400	32	26	to	to	PART
dti-1400	32	27	show	show	VERB
dti-1400	32	28	microorganisms	microorganism	NOUN
dti-1400	32	29	,	,	PUNCT
dti-1400	32	30	and	and	CCONJ
dti-1400	32	31	cultures	culture	NOUN
dti-1400	32	32	of	of	ADP
dti-1400	32	33	blood	blood	NOUN
dti-1400	32	34	and	and	CCONJ
dti-1400	32	35	cerebrospinal	cerebrospinal	ADJ
dti-1400	32	36	fluid	fluid	NOUN
dti-1400	32	37	(	(	PUNCT
dti-1400	32	38	csf	csf	NOUN
dti-1400	32	39	)	)	PUNCT
dti-1400	32	40	were	be	AUX
dti-1400	32	41	also	also	ADV
dti-1400	32	42	negative	negative	ADJ
dti-1400	32	43	.	.	PUNCT
dti-1400	33	1	although	although	SCONJ
dti-1400	33	2	we	we	PRON
dti-1400	33	3	did	do	AUX
dti-1400	33	4	not	not	PART
dti-1400	33	5	perform	perform	VERB
dti-1400	33	6	a	a	DET
dti-1400	33	7	polymerase	polymerase	NOUN
dti-1400	33	8	chain	chain	NOUN
dti-1400	33	9	reaction	reaction	NOUN
dti-1400	33	10	to	to	PART
dti-1400	33	11	screen	screen	VERB
dti-1400	33	12	the	the	DET
dti-1400	33	13	patient	patient	NOUN
dti-1400	33	14	’s	’s	PART
dti-1400	33	15	csf	csf	NOUN
dti-1400	33	16	for	for	ADP
dti-1400	33	17	hz	hz	NOUN
dti-1400	33	18	virus	virus	NOUN
dti-1400	33	19	dna	dna	PROPN
dti-1400	33	20	,	,	PUNCT
dti-1400	33	21	the	the	DET
dti-1400	33	22	serum	serum	NOUN
dti-1400	33	23	and	and	CCONJ
dti-1400	33	24	csf	csf	PROPN
dti-1400	33	25	acyclovir	acyclovir	PROPN
dti-1400	33	26	levels	level	NOUN
dti-1400	33	27	at	at	ADP
dti-1400	33	28	this	this	DET
dti-1400	33	29	point	point	NOUN
dti-1400	33	30	were	be	AUX
dti-1400	33	31	26.9	26.9	NUM
dti-1400	33	32	and	and	CCONJ
dti-1400	33	33	6.25	6.25	NUM
dti-1400	33	34	μg	μg	NOUN
dti-1400	33	35	/	/	SYM
dti-1400	33	36	ml	ml	PROPN
dti-1400	33	37	,	,	PUNCT
dti-1400	33	38	respectively	respectively	ADV
dti-1400	33	39	;	;	PUNCT
dti-1400	33	40	as	as	SCONJ
dti-1400	33	41	such	such	ADJ
dti-1400	33	42	,	,	PUNCT
dti-1400	33	43	valacyclovir	valacyclovir	PROPN
dti-1400	33	44	-	-	PUNCT
dti-1400	33	45	related	relate	VERB
dti-1400	33	46	pathologies	pathology	NOUN
dti-1400	33	47	were	be	AUX
dti-1400	33	48	strongly	strongly	ADV
dti-1400	33	49	suspected	suspect	VERB
dti-1400	33	50	to	to	PART
dti-1400	33	51	be	be	AUX
dti-1400	33	52	implicated	implicate	VERB
dti-1400	33	53	in	in	ADP
dti-1400	33	54	the	the	DET
dti-1400	33	55	patient	patient	NOUN
dti-1400	33	56	’s	’s	PART
dti-1400	33	57	neuropsychiatric	neuropsychiatric	ADJ
dti-1400	33	58	manifestations	manifestation	NOUN
dti-1400	33	59	.	.	PUNCT
dti-1400	34	1	all	all	DET
dti-1400	34	2	medications	medication	NOUN
dti-1400	34	3	were	be	AUX
dti-1400	34	4	discontinued	discontinue	VERB
dti-1400	34	5	,	,	PUNCT
dti-1400	34	6	and	and	CCONJ
dti-1400	34	7	she	she	PRON
dti-1400	34	8	was	be	AUX
dti-1400	34	9	subjected	subject	VERB
dti-1400	34	10	to	to	ADP
dti-1400	34	11	a	a	DET
dti-1400	34	12	single	single	ADJ
dti-1400	34	13	session	session	NOUN
dti-1400	34	14	of	of	ADP
dti-1400	34	15	hemofiltration	hemofiltration	NOUN
dti-1400	34	16	(	(	PUNCT
dti-1400	34	17	hf	hf	NOUN
dti-1400	34	18	)	)	PUNCT
dti-1400	34	19	for	for	ADP
dti-1400	34	20	the	the	DET
dti-1400	34	21	management	management	NOUN
dti-1400	34	22	of	of	ADP
dti-1400	34	23	anuric	anuric	ADJ
dti-1400	34	24	aki	aki	NOUN
dti-1400	34	25	accompanied	accompany	VERB
dti-1400	34	26	by	by	ADP
dti-1400	34	27	hyperkalemia	hyperkalemia	NOUN
dti-1400	34	28	and	and	CCONJ
dti-1400	34	29	hyponatremia	hyponatremia	NOUN
dti-1400	34	30	when	when	SCONJ
dti-1400	34	31	her	her	PRON
dti-1400	34	32	neurological	neurological	ADJ
dti-1400	34	33	status	status	NOUN
dti-1400	34	34	further	far	ADV
dti-1400	34	35	worsened	worsen	VERB
dti-1400	34	36	(	(	PUNCT
dti-1400	34	37	e1v1m4	e1v1m4	ADV
dti-1400	34	38	on	on	ADP
dti-1400	34	39	gcs	gcs	PROPN
dti-1400	34	40	)	)	PUNCT
dti-1400	34	41	.	.	PUNCT
dti-1400	35	1	a	a	DET
dti-1400	35	2	temporary	temporary	ADJ
dti-1400	35	3	dialysis	dialysis	NOUN
dti-1400	35	4	catheter	catheter	NOUN
dti-1400	35	5	was	be	AUX
dti-1400	35	6	placed	place	VERB
dti-1400	35	7	in	in	ADP
dti-1400	35	8	the	the	DET
dti-1400	35	9	right	right	ADJ
dti-1400	35	10	jugular	jugular	PROPN
dti-1400	35	11	vein	vein	NOUN
dti-1400	35	12	and	and	CCONJ
dti-1400	35	13	a	a	DET
dti-1400	35	14	foley	foley	ADJ
dti-1400	35	15	catheter	catheter	NOUN
dti-1400	35	16	was	be	AUX
dti-1400	35	17	inserted	insert	VERB
dti-1400	35	18	in	in	ADP
dti-1400	35	19	the	the	DET
dti-1400	35	20	bladder	bladder	NOUN
dti-1400	35	21	to	to	PART
dti-1400	35	22	monitor	monitor	VERB
dti-1400	35	23	the	the	DET
dti-1400	35	24	urine	urine	NOUN
dti-1400	35	25	output	output	NOUN
dti-1400	35	26	.	.	PUNCT
dti-1400	36	1	then	then	ADV
dti-1400	36	2	,	,	PUNCT
dti-1400	36	3	hf	hf	PROPN
dti-1400	36	4	was	be	AUX
dti-1400	36	5	initiated	initiate	VERB
dti-1400	36	6	with	with	ADP
dti-1400	36	7	a	a	DET
dti-1400	36	8	high	high	ADJ
dti-1400	36	9	-	-	PUNCT
dti-1400	36	10	flux	flux	NOUN
dti-1400	36	11	hemodialyzer	hemodialyzer	NOUN
dti-1400	36	12	(	(	PUNCT
dti-1400	36	13	fb-70u	fb-70u	ADJ
dti-1400	36	14	,	,	PUNCT
dti-1400	36	15	cellulose	cellulose	NOUN
dti-1400	36	16	triacetate	triacetate	NOUN
dti-1400	36	17	membrane	membrane	NOUN
dti-1400	36	18	,	,	PUNCT
dti-1400	36	19	0.7	0.7	NUM
dti-1400	36	20	m2	m2	NOUN
dti-1400	36	21	;	;	PUNCT
dti-1400	36	22	nipro	nipro	PROPN
dti-1400	36	23	co.	co.	PROPN
dti-1400	36	24	,	,	PUNCT
dti-1400	36	25	osaka	osaka	PROPN
dti-1400	36	26	,	,	PUNCT
dti-1400	36	27	japan	japan	PROPN
dti-1400	36	28	)	)	PUNCT
dti-1400	36	29	.	.	PUNCT
dti-1400	37	1	the	the	DET
dti-1400	37	2	rates	rate	NOUN
dti-1400	37	3	of	of	ADP
dti-1400	37	4	blood	blood	NOUN
dti-1400	37	5	flow	flow	NOUN
dti-1400	37	6	and	and	CCONJ
dti-1400	37	7	ultrafiltration	ultrafiltration	NOUN
dti-1400	37	8	were	be	AUX
dti-1400	37	9	set	set	VERB
dti-1400	37	10	at	at	ADP
dti-1400	37	11	120	120	NUM
dti-1400	37	12	ml	ml	NOUN
dti-1400	37	13	/	/	SYM
dti-1400	37	14	min	min	NOUN
dti-1400	37	15	and	and	CCONJ
dti-1400	37	16	1000	1000	NUM
dti-1400	37	17	ml	ml	NOUN
dti-1400	37	18	/	/	SYM
dti-1400	37	19	h	h	NOUN
dti-1400	37	20	,	,	PUNCT
dti-1400	37	21	respectively	respectively	ADV
dti-1400	37	22	.	.	PUNCT
dti-1400	38	1	the	the	DET
dti-1400	38	2	hf	hf	PROPN
dti-1400	38	3	replacement	replacement	NOUN
dti-1400	38	4	fluid	fluid	NOUN
dti-1400	38	5	was	be	AUX
dti-1400	38	6	the	the	DET
dti-1400	38	7	standard	standard	ADJ
dti-1400	38	8	formulation	formulation	NOUN
dti-1400	38	9	of	of	ADP
dti-1400	38	10	sublood	sublood	PROPN
dti-1400	38	11	®	®	NOUN
dti-1400	38	12	-bsg	-bsg	PUNCT
dti-1400	38	13	(	(	PUNCT
dti-1400	38	14	fuso	fuso	PROPN
dti-1400	38	15	pharmaceutical	pharmaceutical	PROPN
dti-1400	38	16	industries	industries	PROPN
dti-1400	38	17	ltd	ltd	PROPN
dti-1400	38	18	.	.	PROPN
dti-1400	38	19	,	,	PUNCT
dti-1400	38	20	osaka	osaka	PROPN
dti-1400	38	21	,	,	PUNCT
dti-1400	38	22	japan	japan	PROPN
dti-1400	38	23	)	)	PUNCT
dti-1400	38	24	administered	administer	VERB
dti-1400	38	25	after	after	ADP
dti-1400	38	26	filter	filter	NOUN
dti-1400	38	27	at	at	ADP
dti-1400	38	28	1000	1000	NUM
dti-1400	38	29	ml	ml	NOUN
dti-1400	38	30	/	/	SYM
dti-1400	38	31	h.	h.	NOUN
dti-1400	38	32	after	after	ADP
dti-1400	38	33	3	3	NUM
dti-1400	38	34	hours	hour	NOUN
dti-1400	38	35	,	,	PUNCT
dti-1400	38	36	the	the	DET
dti-1400	38	37	patient	patient	NOUN
dti-1400	38	38	developed	develop	VERB
dti-1400	38	39	respiratory	respiratory	ADJ
dti-1400	38	40	distress	distress	NOUN
dti-1400	38	41	due	due	ADP
dti-1400	38	42	to	to	ADP
dti-1400	38	43	aspiration	aspiration	NOUN
dti-1400	38	44	and	and	CCONJ
dti-1400	38	45	was	be	AUX
dti-1400	38	46	intubated	intubate	VERB
dti-1400	38	47	for	for	ADP
dti-1400	38	48	airway	airway	NOUN
dti-1400	38	49	protection	protection	NOUN
dti-1400	38	50	,	,	PUNCT
dti-1400	38	51	and	and	CCONJ
dti-1400	38	52	then	then	ADV
dti-1400	38	53	she	she	PRON
dti-1400	38	54	was	be	AUX
dti-1400	38	55	placed	place	VERB
dti-1400	38	56	on	on	ADP
dti-1400	38	57	mechanical	mechanical	ADJ
dti-1400	38	58	ventilation	ventilation	NOUN
dti-1400	38	59	when	when	SCONJ
dti-1400	38	60	an	an	DET
dti-1400	38	61	urgent	urgent	ADJ
dti-1400	38	62	laboratory	laboratory	NOUN
dti-1400	38	63	analysis	analysis	NOUN
dti-1400	38	64	revealed	reveal	VERB
dti-1400	38	65	that	that	SCONJ
dti-1400	38	66	her	her	PRON
dti-1400	38	67	serum	serum	NOUN
dti-1400	38	68	levels	level	NOUN
dti-1400	38	69	of	of	ADP
dti-1400	38	70	potassium	potassium	NOUN
dti-1400	38	71	and	and	CCONJ
dti-1400	38	72	sodium	sodium	NOUN
dti-1400	38	73	were	be	AUX
dti-1400	38	74	4.1	4.1	NUM
dti-1400	38	75	and	and	CCONJ
dti-1400	38	76	124	124	NUM
dti-1400	38	77	mmol	mmol	NOUN
dti-1400	38	78	/	/	SYM
dti-1400	38	79	l	l	NOUN
dti-1400	38	80	,	,	PUNCT
dti-1400	38	81	respectively	respectively	ADV
dti-1400	38	82	.	.	PUNCT
dti-1400	39	1	hf	hf	PROPN
dti-1400	39	2	was	be	AUX
dti-1400	39	3	ceased	cease	VERB
dti-1400	39	4	,	,	PUNCT
dti-1400	39	5	and	and	CCONJ
dti-1400	39	6	she	she	PRON
dti-1400	39	7	was	be	AUX
dti-1400	39	8	then	then	ADV
dti-1400	39	9	started	start	VERB
dti-1400	39	10	on	on	ADP
dti-1400	39	11	intravenous	intravenous	ADJ
dti-1400	39	12	3	3	NUM
dti-1400	39	13	%	%	NOUN
dti-1400	39	14	hypertonic	hypertonic	ADJ
dti-1400	39	15	saline	saline	NOUN
dti-1400	39	16	of	of	ADP
dti-1400	39	17	varying	vary	VERB
dti-1400	39	18	doses	dose	NOUN
dti-1400	39	19	to	to	PART
dti-1400	39	20	correct	correct	VERB
dti-1400	39	21	the	the	DET
dti-1400	39	22	reduced	reduce	VERB
dti-1400	39	23	serum	serum	NOUN
dti-1400	39	24	sodium	sodium	NOUN
dti-1400	39	25	level	level	NOUN
dti-1400	39	26	at	at	ADP
dti-1400	39	27	a	a	DET
dti-1400	39	28	recommended	recommend	VERB
dti-1400	39	29	rate	rate	NOUN
dti-1400	39	30	according	accord	VERB
dti-1400	39	31	to	to	ADP
dti-1400	39	32	the	the	DET
dti-1400	39	33	therapeutic	therapeutic	ADJ
dti-1400	39	34	guidance.7	guidance.7	NOUN
dti-1400	39	35	on	on	ADP
dti-1400	39	36	the	the	DET
dti-1400	39	37	following	following	ADJ
dti-1400	39	38	day	day	NOUN
dti-1400	39	39	,	,	PUNCT
dti-1400	39	40	there	there	PRON
dti-1400	39	41	was	be	VERB
dti-1400	39	42	a	a	DET
dti-1400	39	43	slight	slight	ADJ
dti-1400	39	44	improvement	improvement	NOUN
dti-1400	39	45	in	in	ADP
dti-1400	39	46	the	the	DET
dti-1400	39	47	patient	patient	NOUN
dti-1400	39	48	’s	’s	PART
dti-1400	39	49	neurological	neurological	ADJ
dti-1400	39	50	status	status	NOUN
dti-1400	39	51	(	(	PUNCT
dti-1400	39	52	e2vtm4	e2vtm4	NOUN
dti-1400	39	53	)	)	PUNCT
dti-1400	39	54	,	,	PUNCT
dti-1400	39	55	and	and	CCONJ
dti-1400	39	56	the	the	DET
dti-1400	39	57	serum	serum	NOUN
dti-1400	39	58	sodium	sodium	NOUN
dti-1400	39	59	level	level	NOUN
dti-1400	39	60	increased	increase	VERB
dti-1400	39	61	to	to	ADP
dti-1400	39	62	131	131	NUM
dti-1400	39	63	mmol	mmol	NOUN
dti-1400	39	64	/	/	SYM
dti-1400	39	65	l	l	NOUN
dti-1400	39	66	when	when	SCONJ
dti-1400	39	67	the	the	DET
dti-1400	39	68	patient	patient	NOUN
dti-1400	39	69	underwent	undergo	VERB
dti-1400	39	70	a	a	DET
dti-1400	39	71	3	3	NUM
dti-1400	39	72	-	-	PUNCT
dti-1400	39	73	hour	hour	NOUN
dti-1400	39	74	session	session	NOUN
dti-1400	39	75	of	of	ADP
dti-1400	39	76	hemoperfusion	hemoperfusion	NOUN
dti-1400	39	77	(	(	PUNCT
dti-1400	39	78	hp	hp	PROPN
dti-1400	39	79	)	)	PUNCT
dti-1400	39	80	using	use	VERB
dti-1400	39	81	an	an	DET
dti-1400	39	82	activated	activated	ADJ
dti-1400	39	83	charcoal	charcoal	NOUN
dti-1400	39	84	cartridge	cartridge	NOUN
dti-1400	39	85	(	(	PUNCT
dti-1400	39	86	hemosorba	hemosorba	PROPN
dti-1400	39	87	chs-350	chs-350	PROPN
dti-1400	39	88	®	®	PROPN
dti-1400	39	89	;	;	PUNCT
dti-1400	39	90	asahi	asahi	PROPN
dti-1400	39	91	medical	medical	PROPN
dti-1400	39	92	co.	co.	PROPN
dti-1400	39	93	,	,	PUNCT
dti-1400	39	94	tokyo	tokyo	PROPN
dti-1400	39	95	,	,	PUNCT
dti-1400	39	96	japan	japan	PROPN
dti-1400	39	97	)	)	PUNCT
dti-1400	39	98	,	,	PUNCT
dti-1400	39	99	and	and	CCONJ
dti-1400	39	100	it	it	PRON
dti-1400	39	101	further	far	ADV
dti-1400	39	102	increased	increase	VERB
dti-1400	39	103	to	to	ADP
dti-1400	39	104	139	139	NUM
dti-1400	39	105	mmol	mmol	NOUN
dti-1400	39	106	/	/	SYM
dti-1400	39	107	l	l	NOUN
dti-1400	39	108	at	at	ADP
dti-1400	39	109	14	14	NUM
dti-1400	39	110	hours	hour	NOUN
dti-1400	39	111	later	later	ADV
dti-1400	39	112	.	.	PUNCT
dti-1400	40	1	after	after	ADP
dti-1400	40	2	an	an	DET
dti-1400	40	3	initial	initial	ADJ
dti-1400	40	4	hemodialysis	hemodialysis	NOUN
dti-1400	40	5	(	(	PUNCT
dti-1400	40	6	hd	hd	NOUN
dti-1400	40	7	)	)	PUNCT
dti-1400	40	8	session	session	NOUN
dti-1400	40	9	,	,	PUNCT
dti-1400	40	10	her	her	PRON
dti-1400	40	11	urine	urine	NOUN
dti-1400	40	12	output	output	NOUN
dti-1400	40	13	began	begin	VERB
dti-1400	40	14	to	to	PART
dti-1400	40	15	increase	increase	VERB
dti-1400	40	16	(	(	PUNCT
dti-1400	40	17	figure	figure	NOUN
dti-1400	40	18	1	1	NUM
dti-1400	40	19	)	)	PUNCT
dti-1400	40	20	along	along	ADP
dti-1400	40	21	with	with	ADP
dti-1400	40	22	gradual	gradual	ADJ
dti-1400	40	23	improvements	improvement	NOUN
dti-1400	40	24	in	in	ADP
dti-1400	40	25	her	her	PRON
dti-1400	40	26	consciousness	consciousness	NOUN
dti-1400	40	27	from	from	ADP
dti-1400	40	28	e3vtm6	e3vtm6	PRON
dti-1400	40	29	on	on	ADP
dti-1400	40	30	hospital	hospital	NOUN
dti-1400	40	31	day	day	NOUN
dti-1400	40	32	3	3	NUM
dti-1400	40	33	to	to	ADP
dti-1400	40	34	e4vtm6	e4vtm6	PROPN
dti-1400	40	35	on	on	ADP
dti-1400	40	36	hospital	hospital	NOUN
dti-1400	40	37	day	day	NOUN
dti-1400	40	38	5	5	NUM
dti-1400	40	39	,	,	PUNCT
dti-1400	40	40	whereas	whereas	SCONJ
dti-1400	40	41	the	the	DET
dti-1400	40	42	serum	serum	NOUN
dti-1400	40	43	levels	level	NOUN
dti-1400	40	44	of	of	ADP
dti-1400	40	45	figure	figure	NOUN
dti-1400	40	46	1	1	NUM
dti-1400	40	47	.	.	PUNCT
dti-1400	41	1	serial	serial	ADJ
dti-1400	41	2	changes	change	NOUN
dti-1400	41	3	in	in	ADP
dti-1400	41	4	the	the	DET
dti-1400	41	5	scr	scr	NOUN
dti-1400	41	6	,	,	PUNCT
dti-1400	41	7	serum	serum	NOUN
dti-1400	41	8	sodium	sodium	NOUN
dti-1400	41	9	levels	level	NOUN
dti-1400	41	10	,	,	PUNCT
dti-1400	41	11	and	and	CCONJ
dti-1400	41	12	urine	urine	NOUN
dti-1400	41	13	volume	volume	NOUN
dti-1400	41	14	during	during	ADP
dti-1400	41	15	the	the	DET
dti-1400	41	16	observation	observation	NOUN
dti-1400	41	17	period	period	NOUN
dti-1400	41	18	.	.	PUNCT
dti-1400	42	1	hf	hf	NOUN
dti-1400	42	2	and	and	CCONJ
dti-1400	42	3	hp	hp	PROPN
dti-1400	42	4	were	be	AUX
dti-1400	42	5	performed	perform	VERB
dti-1400	42	6	on	on	ADP
dti-1400	42	7	hospital	hospital	NOUN
dti-1400	42	8	days	day	NOUN
dti-1400	42	9	1	1	NUM
dti-1400	42	10	and	and	CCONJ
dti-1400	42	11	2	2	NUM
dti-1400	42	12	,	,	PUNCT
dti-1400	42	13	respectively	respectively	ADV
dti-1400	42	14	,	,	PUNCT
dti-1400	42	15	whereas	whereas	SCONJ
dti-1400	42	16	the	the	DET
dti-1400	42	17	patient	patient	NOUN
dti-1400	42	18	received	receive	VERB
dti-1400	42	19	the	the	DET
dti-1400	42	20	hd	hd	NOUN
dti-1400	42	21	treatment	treatment	NOUN
dti-1400	42	22	on	on	ADP
dti-1400	42	23	hospital	hospital	NOUN
dti-1400	42	24	days	day	NOUN
dti-1400	42	25	3	3	NUM
dti-1400	42	26	and	and	CCONJ
dti-1400	42	27	5	5	NUM
dti-1400	42	28	.	.	PUNCT
dti-1400	43	1	the	the	DET
dti-1400	43	2	administration	administration	NOUN
dti-1400	43	3	of	of	ADP
dti-1400	43	4	intravenous	intravenous	ADJ
dti-1400	43	5	hypertonic	hypertonic	ADJ
dti-1400	43	6	saline	saline	NOUN
dti-1400	43	7	was	be	AUX
dti-1400	43	8	ceased	cease	VERB
dti-1400	43	9	after	after	ADP
dti-1400	43	10	confirming	confirm	VERB
dti-1400	43	11	that	that	SCONJ
dti-1400	43	12	the	the	DET
dti-1400	43	13	patient	patient	NOUN
dti-1400	43	14	’s	’s	PART
dti-1400	43	15	serum	serum	NOUN
dti-1400	43	16	sodium	sodium	NOUN
dti-1400	43	17	level	level	NOUN
dti-1400	43	18	had	have	AUX
dti-1400	43	19	been	be	AUX
dti-1400	43	20	corrected	correct	VERB
dti-1400	43	21	to	to	ADP
dti-1400	43	22	139	139	NUM
dti-1400	43	23	mmol	mmol	NOUN
dti-1400	43	24	/	/	SYM
dti-1400	43	25	l	l	NOUN
dti-1400	43	26	on	on	ADP
dti-1400	43	27	hospital	hospital	NOUN
dti-1400	43	28	day	day	NOUN
dti-1400	43	29	3	3	NUM
dti-1400	43	30	.	.	PUNCT
dti-1400	43	31	murakami	murakami	NOUN
dti-1400	43	32	et	et	PROPN
dti-1400	43	33	al	al	PROPN
dti-1400	43	34	3	3	NUM
dti-1400	43	35	acyclovir	acyclovir	PROPN
dti-1400	43	36	steadily	steadily	ADV
dti-1400	43	37	decreased	decrease	VERB
dti-1400	43	38	during	during	ADP
dti-1400	43	39	the	the	DET
dti-1400	43	40	observation	observation	NOUN
dti-1400	43	41	period	period	NOUN
dti-1400	43	42	(	(	PUNCT
dti-1400	43	43	table	table	NOUN
dti-1400	43	44	1	1	NUM
dti-1400	43	45	)	)	PUNCT
dti-1400	43	46	.	.	PUNCT
dti-1400	44	1	the	the	DET
dti-1400	44	2	patient	patient	NOUN
dti-1400	44	3	was	be	AUX
dti-1400	44	4	eventually	eventually	ADV
dti-1400	44	5	extubated	extubate	VERB
dti-1400	44	6	on	on	ADP
dti-1400	44	7	hospital	hospital	NOUN
dti-1400	44	8	day	day	NOUN
dti-1400	44	9	7	7	NUM
dti-1400	44	10	with	with	ADP
dti-1400	44	11	a	a	DET
dti-1400	44	12	favorable	favorable	ADJ
dti-1400	44	13	neurological	neurological	ADJ
dti-1400	44	14	recovery	recovery	NOUN
dti-1400	44	15	(	(	PUNCT
dti-1400	44	16	e4v5m6	e4v5m6	NOUN
dti-1400	44	17	)	)	PUNCT
dti-1400	44	18	,	,	PUNCT
dti-1400	44	19	and	and	CCONJ
dti-1400	44	20	medications	medication	NOUN
dti-1400	44	21	including	include	VERB
dti-1400	44	22	statins	statin	NOUN
dti-1400	44	23	and	and	CCONJ
dti-1400	44	24	antihypertensive	antihypertensive	ADJ
dti-1400	44	25	agents	agent	NOUN
dti-1400	44	26	were	be	AUX
dti-1400	44	27	resumed	resume	VERB
dti-1400	44	28	thereafter	thereafter	ADV
dti-1400	44	29	.	.	PUNCT
dti-1400	45	1	she	she	PRON
dti-1400	45	2	was	be	AUX
dti-1400	45	3	discharged	discharge	VERB
dti-1400	45	4	on	on	ADP
dti-1400	45	5	hospital	hospital	NOUN
dti-1400	45	6	day	day	NOUN
dti-1400	45	7	16	16	NUM
dti-1400	45	8	,	,	PUNCT
dti-1400	45	9	having	having	AUX
dti-1400	45	10	fully	fully	ADV
dti-1400	45	11	returned	return	VERB
dti-1400	45	12	to	to	ADP
dti-1400	45	13	her	her	PRON
dti-1400	45	14	normal	normal	ADJ
dti-1400	45	15	baseline	baseline	ADJ
dti-1400	45	16	mental	mental	ADJ
dti-1400	45	17	status	status	NOUN
dti-1400	45	18	with	with	ADP
dti-1400	45	19	a	a	DET
dti-1400	45	20	recovered	recover	VERB
dti-1400	45	21	scr	scr	NOUN
dti-1400	45	22	level	level	NOUN
dti-1400	45	23	of	of	ADP
dti-1400	45	24	0.68	0.68	NUM
dti-1400	45	25	mg	mg	PROPN
dti-1400	45	26	/	/	SYM
dti-1400	45	27	dl	dl	PROPN
dti-1400	45	28	corresponding	correspond	VERB
dti-1400	45	29	to	to	ADP
dti-1400	45	30	an	an	DET
dti-1400	45	31	ecrcl	ecrcl	NOUN
dti-1400	45	32	of	of	ADP
dti-1400	45	33	60.4	60.4	NUM
dti-1400	45	34	ml	ml	NOUN
dti-1400	45	35	/	/	SYM
dti-1400	45	36	min	min	NOUN
dti-1400	45	37	and	and	CCONJ
dti-1400	45	38	egfr	egfr	NOUN
dti-1400	45	39	of	of	ADP
dti-1400	45	40	65.7	65.7	NUM
dti-1400	45	41	ml	ml	NOUN
dti-1400	45	42	/	/	SYM
dti-1400	45	43	min/1.73	min/1.73	NOUN
dti-1400	45	44	m2	m2	PROPN
dti-1400	45	45	at	at	ADP
dti-1400	45	46	the	the	DET
dti-1400	45	47	time	time	NOUN
dti-1400	45	48	,	,	PUNCT
dti-1400	45	49	the	the	DET
dti-1400	45	50	results	result	NOUN
dti-1400	45	51	of	of	ADP
dti-1400	45	52	a	a	DET
dti-1400	45	53	urine	urine	NOUN
dti-1400	45	54	sediment	sediment	NOUN
dti-1400	45	55	examination	examination	NOUN
dti-1400	45	56	were	be	AUX
dti-1400	45	57	unremarkable	unremarkable	ADJ
dti-1400	45	58	,	,	PUNCT
dti-1400	45	59	and	and	CCONJ
dti-1400	45	60	a	a	DET
dti-1400	45	61	urine	urine	NOUN
dti-1400	45	62	dipstick	dipstick	NOUN
dti-1400	45	63	analysis	analysis	NOUN
dti-1400	45	64	was	be	AUX
dti-1400	45	65	negative	negative	ADJ
dti-1400	45	66	for	for	ADP
dti-1400	45	67	protein	protein	NOUN
dti-1400	45	68	and	and	CCONJ
dti-1400	45	69	occult	occult	NOUN
dti-1400	45	70	blood	blood	NOUN
dti-1400	45	71	.	.	PUNCT
dti-1400	46	1	discussion	discussion	NOUN
dti-1400	46	2	the	the	DET
dti-1400	46	3	clinical	clinical	ADJ
dti-1400	46	4	scenario	scenario	NOUN
dti-1400	46	5	of	of	ADP
dti-1400	46	6	the	the	DET
dti-1400	46	7	present	present	ADJ
dti-1400	46	8	case	case	NOUN
dti-1400	46	9	,	,	PUNCT
dti-1400	46	10	which	which	PRON
dti-1400	46	11	was	be	AUX
dti-1400	46	12	characterized	characterize	VERB
dti-1400	46	13	by	by	ADP
dti-1400	46	14	a	a	DET
dti-1400	46	15	set	set	NOUN
dti-1400	46	16	of	of	ADP
dti-1400	46	17	conditions	condition	NOUN
dti-1400	46	18	including	include	VERB
dti-1400	46	19	neurotoxicity	neurotoxicity	NOUN
dti-1400	46	20	and	and	CCONJ
dti-1400	46	21	aki	aki	NOUN
dti-1400	46	22	in	in	ADP
dti-1400	46	23	an	an	DET
dti-1400	46	24	hz	hz	ADJ
dti-1400	46	25	patient	patient	NOUN
dti-1400	46	26	receiving	receive	VERB
dti-1400	46	27	valacyclovir	valacyclovir	NOUN
dti-1400	46	28	may	may	AUX
dti-1400	46	29	be	be	AUX
dti-1400	46	30	too	too	ADV
dti-1400	46	31	common	common	ADJ
dti-1400	46	32	to	to	PART
dti-1400	46	33	be	be	AUX
dti-1400	46	34	described	describe	VERB
dti-1400	46	35	in	in	ADP
dti-1400	46	36	the	the	DET
dti-1400	46	37	literature	literature	NOUN
dti-1400	46	38	.	.	PUNCT
dti-1400	47	1	indeed	indeed	ADV
dti-1400	47	2	,	,	PUNCT
dti-1400	47	3	there	there	PRON
dti-1400	47	4	are	be	VERB
dti-1400	47	5	numerous	numerous	ADJ
dti-1400	47	6	reports	report	NOUN
dti-1400	47	7	of	of	ADP
dti-1400	47	8	nephrotoxic	nephrotoxic	ADJ
dti-1400	47	9	and	and	CCONJ
dti-1400	47	10	neuropsychiatric	neuropsychiatric	ADJ
dti-1400	47	11	side	side	NOUN
dti-1400	47	12	effects	effect	NOUN
dti-1400	47	13	in	in	ADP
dti-1400	47	14	acyclovirtreated	acyclovirtreated	ADJ
dti-1400	47	15	patients	patient	NOUN
dti-1400	47	16	,	,	PUNCT
dti-1400	47	17	whereas	whereas	SCONJ
dti-1400	47	18	aki	aki	NOUN
dti-1400	47	19	and	and	CCONJ
dti-1400	47	20	various	various	ADJ
dti-1400	47	21	neurological	neurological	ADJ
dti-1400	47	22	manifestations	manifestation	NOUN
dti-1400	47	23	are	be	AUX
dti-1400	47	24	occasionally	occasionally	ADV
dti-1400	47	25	observed	observe	VERB
dti-1400	47	26	as	as	ADP
dti-1400	47	27	characteristic	characteristic	ADJ
dti-1400	47	28	phenotypes	phenotype	NOUN
dti-1400	47	29	of	of	ADP
dti-1400	47	30	valacyclovir	valacyclovir	NOUN
dti-1400	47	31	toxicity.3,4,8–11	toxicity.3,4,8–11	VERB
dti-1400	47	32	however	however	ADV
dti-1400	47	33	,	,	PUNCT
dti-1400	47	34	the	the	DET
dti-1400	47	35	significance	significance	NOUN
dti-1400	47	36	of	of	ADP
dti-1400	47	37	this	this	DET
dti-1400	47	38	report	report	NOUN
dti-1400	47	39	should	should	AUX
dti-1400	47	40	be	be	AUX
dti-1400	47	41	carefully	carefully	ADV
dti-1400	47	42	evaluated	evaluate	VERB
dti-1400	47	43	to	to	PART
dti-1400	47	44	investigate	investigate	VERB
dti-1400	47	45	the	the	DET
dti-1400	47	46	impact	impact	NOUN
dti-1400	47	47	of	of	ADP
dti-1400	47	48	concurrent	concurrent	ADJ
dti-1400	47	49	hyponatremia	hyponatremia	NOUN
dti-1400	47	50	on	on	ADP
dti-1400	47	51	the	the	DET
dti-1400	47	52	therapeutic	therapeutic	ADJ
dti-1400	47	53	decisions	decision	NOUN
dti-1400	47	54	in	in	ADP
dti-1400	47	55	the	the	DET
dti-1400	47	56	present	present	ADJ
dti-1400	47	57	case	case	NOUN
dti-1400	47	58	.	.	PUNCT
dti-1400	48	1	furthermore	furthermore	ADV
dti-1400	48	2	,	,	PUNCT
dti-1400	48	3	our	our	PRON
dti-1400	48	4	experience	experience	NOUN
dti-1400	48	5	underscores	underscore	VERB
dti-1400	48	6	the	the	DET
dti-1400	48	7	pitfalls	pitfall	NOUN
dti-1400	48	8	associated	associate	VERB
dti-1400	48	9	with	with	ADP
dti-1400	48	10	valacyclovir	valacyclovir	PROPN
dti-1400	48	11	treatment	treatment	NOUN
dti-1400	48	12	for	for	ADP
dti-1400	48	13	hz	hz	NOUN
dti-1400	48	14	,	,	PUNCT
dti-1400	48	15	implying	imply	VERB
dti-1400	48	16	its	its	PRON
dti-1400	48	17	limited	limited	ADJ
dti-1400	48	18	feasibility	feasibility	NOUN
dti-1400	48	19	and	and	CCONJ
dti-1400	48	20	safety	safety	NOUN
dti-1400	48	21	,	,	PUNCT
dti-1400	48	22	especially	especially	ADV
dti-1400	48	23	in	in	ADP
dti-1400	48	24	elderly	elderly	ADJ
dti-1400	48	25	patients	patient	NOUN
dti-1400	48	26	.	.	PUNCT
dti-1400	49	1	the	the	DET
dti-1400	49	2	withdrawal	withdrawal	NOUN
dti-1400	49	3	or	or	CCONJ
dti-1400	49	4	discontinuation	discontinuation	NOUN
dti-1400	49	5	of	of	ADP
dti-1400	49	6	the	the	DET
dti-1400	49	7	offending	offending	ADJ
dti-1400	49	8	agent	agent	NOUN
dti-1400	49	9	is	be	AUX
dti-1400	49	10	the	the	DET
dti-1400	49	11	mainstay	mainstay	NOUN
dti-1400	49	12	treatment	treatment	NOUN
dti-1400	49	13	for	for	ADP
dti-1400	49	14	acyclovir	acyclovir	PROPN
dti-1400	49	15	or	or	CCONJ
dti-1400	49	16	valacyclovir	valacyclovir	PROPN
dti-1400	49	17	-	-	PUNCT
dti-1400	49	18	mediated	mediate	VERB
dti-1400	49	19	poisoning	poisoning	NOUN
dti-1400	49	20	;	;	PUNCT
dti-1400	49	21	however	however	ADV
dti-1400	49	22	,	,	PUNCT
dti-1400	49	23	there	there	PRON
dti-1400	49	24	are	be	VERB
dti-1400	49	25	several	several	ADJ
dti-1400	49	26	anecdotal	anecdotal	ADJ
dti-1400	49	27	reports	report	NOUN
dti-1400	49	28	suggesting	suggest	VERB
dti-1400	49	29	that	that	SCONJ
dti-1400	49	30	hd	hd	PROPN
dti-1400	49	31	may	may	AUX
dti-1400	49	32	play	play	VERB
dti-1400	49	33	a	a	DET
dti-1400	49	34	role	role	NOUN
dti-1400	49	35	in	in	ADP
dti-1400	49	36	the	the	DET
dti-1400	49	37	rapid	rapid	ADJ
dti-1400	49	38	reduction	reduction	NOUN
dti-1400	49	39	in	in	ADP
dti-1400	49	40	serum	serum	PROPN
dti-1400	49	41	acyclovir	acyclovir	PROPN
dti-1400	49	42	levels	levels	PROPN
dti-1400	49	43	,	,	PUNCT
dti-1400	49	44	thereby	thereby	ADV
dti-1400	49	45	accelerating	accelerate	VERB
dti-1400	49	46	the	the	DET
dti-1400	49	47	recovery	recovery	NOUN
dti-1400	49	48	from	from	ADP
dti-1400	49	49	renal	renal	ADJ
dti-1400	49	50	and/or	and/or	CCONJ
dti-1400	49	51	neurological	neurological	ADJ
dti-1400	49	52	disorders.4,8,11–14	disorders.4,8,11–14	NOUN
dti-1400	49	53	given	give	VERB
dti-1400	49	54	the	the	DET
dti-1400	49	55	chemical	chemical	ADJ
dti-1400	49	56	and	and	CCONJ
dti-1400	49	57	pharmacokinetic	pharmacokinetic	ADJ
dti-1400	49	58	characteristics	characteristic	NOUN
dti-1400	49	59	of	of	ADP
dti-1400	49	60	acyclovir	acyclovir	PROPN
dti-1400	49	61	,	,	PUNCT
dti-1400	49	62	including	include	VERB
dti-1400	49	63	its	its	PRON
dti-1400	49	64	small	small	ADJ
dti-1400	49	65	molecular	molecular	ADJ
dti-1400	49	66	weight	weight	NOUN
dti-1400	49	67	(	(	PUNCT
dti-1400	49	68	225	225	NUM
dti-1400	49	69	da	da	NOUN
dti-1400	49	70	)	)	PUNCT
dti-1400	49	71	,	,	PUNCT
dti-1400	49	72	limited	limited	ADJ
dti-1400	49	73	protein	protein	NOUN
dti-1400	49	74	-	-	PUNCT
dti-1400	49	75	binding	bind	VERB
dti-1400	49	76	rate	rate	NOUN
dti-1400	49	77	,	,	PUNCT
dti-1400	49	78	low	low	ADJ
dti-1400	49	79	steady	steady	ADJ
dti-1400	49	80	-	-	PUNCT
dti-1400	49	81	state	state	NOUN
dti-1400	49	82	volume	volume	NOUN
dti-1400	49	83	of	of	ADP
dti-1400	49	84	distribution	distribution	NOUN
dti-1400	49	85	,	,	PUNCT
dti-1400	49	86	and	and	CCONJ
dti-1400	49	87	high	high	ADJ
dti-1400	49	88	water	water	NOUN
dti-1400	49	89	solubility	solubility	NOUN
dti-1400	49	90	,	,	PUNCT
dti-1400	49	91	it	it	PRON
dti-1400	49	92	can	can	AUX
dti-1400	49	93	be	be	AUX
dti-1400	49	94	readily	readily	ADV
dti-1400	49	95	removed	remove	VERB
dti-1400	49	96	with	with	ADP
dti-1400	49	97	extracorporeal	extracorporeal	NOUN
dti-1400	49	98	procedures	procedure	NOUN
dti-1400	49	99	,	,	PUNCT
dti-1400	49	100	including	include	VERB
dti-1400	49	101	hd	hd	NOUN
dti-1400	49	102	,	,	PUNCT
dti-1400	49	103	hf	hf	NOUN
dti-1400	49	104	,	,	PUNCT
dti-1400	49	105	and	and	CCONJ
dti-1400	49	106	hemodiafiltration	hemodiafiltration	NOUN
dti-1400	49	107	,	,	PUNCT
dti-1400	49	108	with	with	ADP
dti-1400	49	109	a	a	DET
dti-1400	49	110	high	high	ADJ
dti-1400	49	111	elimination	elimination	NOUN
dti-1400	49	112	rate	rate	NOUN
dti-1400	49	113	in	in	ADP
dti-1400	49	114	hd.4,8,12,15	hd.4,8,12,15	PROPN
dti-1400	49	115	in	in	ADP
dti-1400	49	116	the	the	DET
dti-1400	49	117	present	present	ADJ
dti-1400	49	118	case	case	NOUN
dti-1400	49	119	,	,	PUNCT
dti-1400	49	120	the	the	DET
dti-1400	49	121	concurrent	concurrent	ADJ
dti-1400	49	122	hyponatremia	hyponatremia	NOUN
dti-1400	49	123	precluded	preclude	VERB
dti-1400	49	124	us	we	PRON
dti-1400	49	125	from	from	ADP
dti-1400	49	126	promptly	promptly	ADV
dti-1400	49	127	performing	perform	VERB
dti-1400	49	128	hd	hd	NOUN
dti-1400	49	129	as	as	ADP
dti-1400	49	130	the	the	DET
dti-1400	49	131	procedure	procedure	NOUN
dti-1400	49	132	to	to	PART
dti-1400	49	133	remedy	remedy	VERB
dti-1400	49	134	volume	volume	NOUN
dti-1400	49	135	overload	overload	NOUN
dti-1400	49	136	,	,	PUNCT
dti-1400	49	137	azotemia	azotemia	NOUN
dti-1400	49	138	,	,	PUNCT
dti-1400	49	139	and	and	CCONJ
dti-1400	49	140	abnormal	abnormal	ADJ
dti-1400	49	141	serum	serum	NOUN
dti-1400	49	142	electrolyte	electrolyte	PROPN
dti-1400	49	143	levels	level	NOUN
dti-1400	49	144	results	result	VERB
dti-1400	49	145	in	in	ADP
dti-1400	49	146	the	the	DET
dti-1400	49	147	rapid	rapid	ADJ
dti-1400	49	148	correction	correction	NOUN
dti-1400	49	149	of	of	ADP
dti-1400	49	150	the	the	DET
dti-1400	49	151	serum	serum	NOUN
dti-1400	49	152	sodium	sodium	NOUN
dti-1400	49	153	level	level	NOUN
dti-1400	49	154	and	and	CCONJ
dti-1400	49	155	predisposes	predispose	VERB
dti-1400	49	156	patients	patient	NOUN
dti-1400	49	157	to	to	ADP
dti-1400	49	158	a	a	DET
dti-1400	49	159	risk	risk	NOUN
dti-1400	49	160	of	of	ADP
dti-1400	49	161	osmotic	osmotic	ADJ
dti-1400	49	162	demyelination	demyelination	NOUN
dti-1400	49	163	syndrome	syndrome	NOUN
dti-1400	49	164	(	(	PUNCT
dti-1400	49	165	ods).16	ods).16	NOUN
dti-1400	49	166	in	in	ADP
dti-1400	49	167	this	this	DET
dti-1400	49	168	context	context	NOUN
dti-1400	49	169	,	,	PUNCT
dti-1400	49	170	we	we	PRON
dti-1400	49	171	decided	decide	VERB
dti-1400	49	172	to	to	PART
dti-1400	49	173	perform	perform	VERB
dti-1400	49	174	hf	hf	ADP
dti-1400	49	175	,	,	PUNCT
dti-1400	49	176	which	which	PRON
dti-1400	49	177	may	may	AUX
dti-1400	49	178	have	have	VERB
dti-1400	49	179	a	a	DET
dti-1400	49	180	lower	low	ADJ
dti-1400	49	181	magnitude	magnitude	NOUN
dti-1400	49	182	of	of	ADP
dti-1400	49	183	sodium	sodium	NOUN
dti-1400	49	184	exchange	exchange	NOUN
dti-1400	49	185	than	than	ADP
dti-1400	49	186	hd,17	hd,17	ADJ
dti-1400	49	187	as	as	ADP
dti-1400	49	188	an	an	DET
dti-1400	49	189	initial	initial	ADJ
dti-1400	49	190	mode	mode	NOUN
dti-1400	49	191	of	of	ADP
dti-1400	49	192	blood	blood	NOUN
dti-1400	49	193	purification	purification	NOUN
dti-1400	49	194	with	with	ADP
dti-1400	49	195	the	the	DET
dti-1400	49	196	aim	aim	NOUN
dti-1400	49	197	of	of	ADP
dti-1400	49	198	correcting	correct	VERB
dti-1400	49	199	the	the	DET
dti-1400	49	200	hyperkalemia	hyperkalemia	NOUN
dti-1400	49	201	associated	associate	VERB
dti-1400	49	202	with	with	ADP
dti-1400	49	203	aki	aki	NOUN
dti-1400	49	204	as	as	ADV
dti-1400	49	205	well	well	ADV
dti-1400	49	206	as	as	ADP
dti-1400	49	207	active	active	ADJ
dti-1400	49	208	acyclovir	acyclovir	PROPN
dti-1400	49	209	removal	removal	PROPN
dti-1400	49	210	,	,	PUNCT
dti-1400	49	211	and	and	CCONJ
dti-1400	49	212	it	it	PRON
dti-1400	49	213	was	be	AUX
dti-1400	49	214	not	not	PART
dti-1400	49	215	until	until	SCONJ
dti-1400	49	216	the	the	DET
dti-1400	49	217	confirmation	confirmation	NOUN
dti-1400	49	218	of	of	ADP
dti-1400	49	219	successfully	successfully	ADV
dti-1400	49	220	corrected	correct	VERB
dti-1400	49	221	serum	serum	NOUN
dti-1400	49	222	sodium	sodium	NOUN
dti-1400	49	223	levels	level	NOUN
dti-1400	49	224	that	that	PRON
dti-1400	49	225	hd	hd	PROPN
dti-1400	49	226	was	be	AUX
dti-1400	49	227	finally	finally	ADV
dti-1400	49	228	applied	apply	VERB
dti-1400	49	229	without	without	ADP
dti-1400	49	230	any	any	DET
dti-1400	49	231	hesitation	hesitation	NOUN
dti-1400	49	232	.	.	PUNCT
dti-1400	50	1	a	a	DET
dti-1400	50	2	lack	lack	NOUN
dti-1400	50	3	of	of	ADP
dti-1400	50	4	information	information	NOUN
dti-1400	50	5	regarding	regard	VERB
dti-1400	50	6	the	the	DET
dti-1400	50	7	therapeutic	therapeutic	ADJ
dti-1400	50	8	benefit	benefit	NOUN
dti-1400	50	9	of	of	ADP
dti-1400	50	10	hf	hf	NOUN
dti-1400	50	11	in	in	ADP
dti-1400	50	12	cases	case	NOUN
dti-1400	50	13	with	with	ADP
dti-1400	50	14	valacyclovir	valacyclovir	PROPN
dti-1400	50	15	or	or	CCONJ
dti-1400	50	16	acyclovir	acyclovir	PROPN
dti-1400	50	17	toxicity18	toxicity18	PROPN
dti-1400	50	18	also	also	ADV
dti-1400	50	19	encouraged	encourage	VERB
dti-1400	50	20	us	we	PRON
dti-1400	50	21	to	to	PART
dti-1400	50	22	employ	employ	VERB
dti-1400	50	23	hp	hp	NOUN
dti-1400	50	24	empirically	empirically	ADV
dti-1400	50	25	as	as	ADP
dti-1400	50	26	an	an	DET
dti-1400	50	27	adjunct	adjunct	ADJ
dti-1400	50	28	treatment	treatment	NOUN
dti-1400	50	29	for	for	ADP
dti-1400	50	30	the	the	DET
dti-1400	50	31	disease	disease	NOUN
dti-1400	50	32	after	after	ADP
dti-1400	50	33	confirming	confirm	VERB
dti-1400	50	34	the	the	DET
dti-1400	50	35	normalization	normalization	NOUN
dti-1400	50	36	of	of	ADP
dti-1400	50	37	the	the	DET
dti-1400	50	38	patient	patient	NOUN
dti-1400	50	39	’s	’s	PART
dti-1400	50	40	serum	serum	NOUN
dti-1400	50	41	potassium	potassium	NOUN
dti-1400	50	42	levels	level	NOUN
dti-1400	50	43	,	,	PUNCT
dti-1400	50	44	although	although	SCONJ
dti-1400	50	45	acyclovir	acyclovir	PROPN
dti-1400	50	46	is	be	AUX
dti-1400	50	47	not	not	PART
dti-1400	50	48	necessarily	necessarily	ADV
dti-1400	50	49	listed	list	VERB
dti-1400	50	50	as	as	ADP
dti-1400	50	51	an	an	DET
dti-1400	50	52	agent	agent	NOUN
dti-1400	50	53	that	that	PRON
dti-1400	50	54	can	can	AUX
dti-1400	50	55	be	be	AUX
dti-1400	50	56	removed	remove	VERB
dti-1400	50	57	by	by	ADP
dti-1400	50	58	this	this	DET
dti-1400	50	59	procedure.19	procedure.19	NOUN
dti-1400	50	60	given	give	VERB
dti-1400	50	61	our	our	PRON
dti-1400	50	62	experience	experience	NOUN
dti-1400	50	63	with	with	ADP
dti-1400	50	64	the	the	DET
dti-1400	50	65	current	current	ADJ
dti-1400	50	66	patient	patient	NOUN
dti-1400	50	67	,	,	PUNCT
dti-1400	50	68	we	we	PRON
dti-1400	50	69	believe	believe	VERB
dti-1400	50	70	that	that	SCONJ
dti-1400	50	71	hf	hf	PROPN
dti-1400	50	72	and/or	and/or	CCONJ
dti-1400	50	73	hp	hp	PROPN
dti-1400	50	74	are	be	AUX
dti-1400	50	75	viable	viable	ADJ
dti-1400	50	76	therapeutic	therapeutic	ADJ
dti-1400	50	77	options	option	NOUN
dti-1400	50	78	in	in	ADP
dti-1400	50	79	patients	patient	NOUN
dti-1400	50	80	with	with	ADP
dti-1400	50	81	hyponatremia	hyponatremia	PROPN
dti-1400	50	82	who	who	PRON
dti-1400	50	83	are	be	AUX
dti-1400	50	84	at	at	ADP
dti-1400	50	85	risk	risk	NOUN
dti-1400	50	86	of	of	ADP
dti-1400	50	87	developing	develop	VERB
dti-1400	50	88	a	a	DET
dti-1400	50	89	rate	rate	NOUN
dti-1400	50	90	of	of	ADP
dti-1400	50	91	sodium	sodium	NOUN
dti-1400	50	92	correction	correction	NOUN
dti-1400	50	93	with	with	ADP
dti-1400	50	94	hd	hd	PROPN
dti-1400	50	95	that	that	PRON
dti-1400	50	96	far	far	ADV
dti-1400	50	97	exceeds	exceed	VERB
dti-1400	50	98	the	the	DET
dti-1400	50	99	safe	safe	ADJ
dti-1400	50	100	recommendation	recommendation	NOUN
dti-1400	50	101	,	,	PUNCT
dti-1400	50	102	although	although	SCONJ
dti-1400	50	103	it	it	PRON
dti-1400	50	104	does	do	AUX
dti-1400	50	105	not	not	PART
dti-1400	50	106	allow	allow	VERB
dti-1400	50	107	us	we	PRON
dti-1400	50	108	to	to	PART
dti-1400	50	109	objectively	objectively	ADV
dti-1400	50	110	determine	determine	VERB
dti-1400	50	111	the	the	DET
dti-1400	50	112	clinical	clinical	ADJ
dti-1400	50	113	impact	impact	NOUN
dti-1400	50	114	of	of	ADP
dti-1400	50	115	each	each	DET
dti-1400	50	116	procedure	procedure	NOUN
dti-1400	50	117	on	on	ADP
dti-1400	50	118	this	this	DET
dti-1400	50	119	pathology	pathology	NOUN
dti-1400	50	120	.	.	PUNCT
dti-1400	51	1	despite	despite	SCONJ
dti-1400	51	2	these	these	DET
dti-1400	51	3	promising	promising	ADJ
dti-1400	51	4	outcomes	outcome	NOUN
dti-1400	51	5	,	,	PUNCT
dti-1400	51	6	our	our	PRON
dti-1400	51	7	policy	policy	NOUN
dti-1400	51	8	regarding	regard	VERB
dti-1400	51	9	tailored	tailor	VERB
dti-1400	51	10	approaches	approach	NOUN
dti-1400	51	11	to	to	ADP
dti-1400	51	12	selecting	select	VERB
dti-1400	51	13	and	and	CCONJ
dti-1400	51	14	scheduling	schedule	VERB
dti-1400	51	15	blood	blood	NOUN
dti-1400	51	16	purification	purification	NOUN
dti-1400	51	17	modalities	modality	NOUN
dti-1400	51	18	in	in	ADP
dti-1400	51	19	the	the	DET
dti-1400	51	20	present	present	ADJ
dti-1400	51	21	patient	patient	NOUN
dti-1400	51	22	may	may	AUX
dti-1400	51	23	not	not	PART
dti-1400	51	24	be	be	AUX
dti-1400	51	25	appropriate	appropriate	ADJ
dti-1400	51	26	because	because	SCONJ
dti-1400	51	27	azotemia	azotemia	NOUN
dti-1400	51	28	and/or	and/or	CCONJ
dti-1400	51	29	uremia	uremia	NOUN
dti-1400	51	30	may	may	AUX
dti-1400	51	31	protect	protect	VERB
dti-1400	51	32	against	against	ADP
dti-1400	51	33	the	the	DET
dti-1400	51	34	demyelination	demyelination	NOUN
dti-1400	51	35	that	that	PRON
dti-1400	51	36	results	result	VERB
dti-1400	51	37	from	from	ADP
dti-1400	51	38	the	the	DET
dti-1400	51	39	rapid	rapid	ADJ
dti-1400	51	40	correction	correction	NOUN
dti-1400	51	41	of	of	ADP
dti-1400	51	42	hyponatremia	hyponatremia	PROPN
dti-1400	51	43	during	during	ADP
dti-1400	51	44	hd.20	hd.20	PROPN
dti-1400	51	45	-	-	PUNCT
dti-1400	51	46	22	22	NUM
dti-1400	51	47	however	however	ADV
dti-1400	51	48	,	,	PUNCT
dti-1400	51	49	we	we	PRON
dti-1400	51	50	believe	believe	VERB
dti-1400	51	51	that	that	SCONJ
dti-1400	51	52	it	it	PRON
dti-1400	51	53	is	be	AUX
dti-1400	51	54	necessary	necessary	ADJ
dti-1400	51	55	to	to	PART
dti-1400	51	56	take	take	VERB
dti-1400	51	57	a	a	DET
dti-1400	51	58	proactive	proactive	ADJ
dti-1400	51	59	approach	approach	NOUN
dti-1400	51	60	before	before	SCONJ
dti-1400	51	61	serious	serious	ADJ
dti-1400	51	62	events	event	NOUN
dti-1400	51	63	become	become	VERB
dti-1400	51	64	apparent	apparent	ADJ
dti-1400	51	65	.	.	PUNCT
dti-1400	52	1	of	of	ADP
dti-1400	52	2	note	note	NOUN
dti-1400	52	3	,	,	PUNCT
dti-1400	52	4	it	it	PRON
dti-1400	52	5	has	have	AUX
dti-1400	52	6	been	be	AUX
dti-1400	52	7	reported	report	VERB
dti-1400	52	8	anecdotally	anecdotally	ADV
dti-1400	52	9	that	that	SCONJ
dti-1400	52	10	uremia	uremia	NOUN
dti-1400	52	11	did	do	AUX
dti-1400	52	12	not	not	PART
dti-1400	52	13	provide	provide	VERB
dti-1400	52	14	full	full	ADJ
dti-1400	52	15	protection	protection	NOUN
dti-1400	52	16	against	against	ADP
dti-1400	52	17	dialysis	dialysis	NOUN
dti-1400	52	18	-	-	PUNCT
dti-1400	52	19	related	relate	VERB
dti-1400	52	20	ods.23	ods.23	NOUN
dti-1400	52	21	the	the	DET
dti-1400	52	22	reason	reason	NOUN
dti-1400	52	23	why	why	SCONJ
dti-1400	52	24	our	our	PRON
dti-1400	52	25	patient	patient	NOUN
dti-1400	52	26	manifested	manifested	ADJ
dti-1400	52	27	hyponatremia	hyponatremia	NOUN
dti-1400	52	28	,	,	PUNCT
dti-1400	52	29	which	which	PRON
dti-1400	52	30	is	be	AUX
dti-1400	52	31	one	one	NUM
dti-1400	52	32	of	of	ADP
dti-1400	52	33	the	the	DET
dti-1400	52	34	most	most	ADV
dti-1400	52	35	common	common	ADJ
dti-1400	52	36	electrolytes	electrolyte	NOUN
dti-1400	52	37	disorders	disorder	NOUN
dti-1400	52	38	encountered	encounter	VERB
dti-1400	52	39	in	in	ADP
dti-1400	52	40	the	the	DET
dti-1400	52	41	ordinary	ordinary	ADJ
dti-1400	52	42	clinical	clinical	ADJ
dti-1400	52	43	setting,7	setting,7	NOUN
dti-1400	52	44	may	may	AUX
dti-1400	52	45	be	be	AUX
dti-1400	52	46	another	another	DET
dti-1400	52	47	point	point	NOUN
dti-1400	52	48	that	that	PRON
dti-1400	52	49	needs	need	VERB
dti-1400	52	50	to	to	PART
dti-1400	52	51	be	be	AUX
dti-1400	52	52	addressed	address	VERB
dti-1400	52	53	carefully	carefully	ADV
dti-1400	52	54	.	.	PUNCT
dti-1400	53	1	although	although	SCONJ
dti-1400	53	2	this	this	DET
dti-1400	53	3	abnormality	abnormality	NOUN
dti-1400	53	4	may	may	AUX
dti-1400	53	5	occasionally	occasionally	ADV
dti-1400	53	6	be	be	AUX
dti-1400	53	7	seen,24	seen,24	VERB
dti-1400	53	8	and	and	CCONJ
dti-1400	53	9	can	can	AUX
dti-1400	53	10	arise	arise	VERB
dti-1400	53	11	in	in	ADP
dti-1400	53	12	a	a	DET
dti-1400	53	13	wide	wide	ADJ
dti-1400	53	14	range	range	NOUN
dti-1400	53	15	of	of	ADP
dti-1400	53	16	diseases	disease	NOUN
dti-1400	53	17	,	,	PUNCT
dti-1400	53	18	a	a	DET
dti-1400	53	19	detailed	detailed	ADJ
dti-1400	53	20	medical	medical	ADJ
dti-1400	53	21	record	record	NOUN
dti-1400	53	22	review	review	NOUN
dti-1400	53	23	,	,	PUNCT
dti-1400	53	24	a	a	DET
dti-1400	53	25	thorough	thorough	ADJ
dti-1400	53	26	clinical	clinical	ADJ
dti-1400	53	27	interview	interview	NOUN
dti-1400	53	28	,	,	PUNCT
dti-1400	53	29	the	the	DET
dti-1400	53	30	patient	patient	NOUN
dti-1400	53	31	’s	’s	PART
dti-1400	53	32	clinical	clinical	ADJ
dti-1400	53	33	manifestations	manifestation	NOUN
dti-1400	53	34	,	,	PUNCT
dti-1400	53	35	and	and	CCONJ
dti-1400	53	36	the	the	DET
dti-1400	53	37	prompt	prompt	ADJ
dti-1400	53	38	and	and	CCONJ
dti-1400	53	39	timely	timely	ADJ
dti-1400	53	40	resolution	resolution	NOUN
dti-1400	53	41	without	without	ADP
dti-1400	53	42	any	any	DET
dti-1400	53	43	recurrence	recurrence	NOUN
dti-1400	53	44	during	during	ADP
dti-1400	53	45	the	the	DET
dti-1400	53	46	observation	observation	NOUN
dti-1400	53	47	period	period	NOUN
dti-1400	53	48	,	,	PUNCT
dti-1400	53	49	hampered	hamper	VERB
dti-1400	53	50	our	our	PRON
dti-1400	53	51	identification	identification	NOUN
dti-1400	53	52	of	of	ADP
dti-1400	53	53	disease	disease	NOUN
dti-1400	53	54	states	state	VERB
dti-1400	53	55	other	other	ADJ
dti-1400	53	56	than	than	ADP
dti-1400	53	57	the	the	DET
dti-1400	53	58	renal	renal	ADJ
dti-1400	53	59	failure.7	failure.7	NOUN
dti-1400	53	60	whether	whether	SCONJ
dti-1400	53	61	there	there	PRON
dti-1400	53	62	is	be	VERB
dti-1400	53	63	any	any	DET
dti-1400	53	64	association	association	NOUN
dti-1400	53	65	between	between	ADP
dti-1400	53	66	valacyclovir	valacyclovir	PROPN
dti-1400	53	67	toxicity	toxicity	NOUN
dti-1400	53	68	and	and	CCONJ
dti-1400	53	69	hyponatremia	hyponatremia	NOUN
dti-1400	53	70	remains	remain	VERB
dti-1400	53	71	inconclusive.25	inconclusive.25	NOUN
dti-1400	53	72	the	the	DET
dti-1400	53	73	hyponatremia	hyponatremia	NOUN
dti-1400	53	74	may	may	AUX
dti-1400	53	75	have	have	AUX
dti-1400	53	76	acted	act	VERB
dti-1400	53	77	as	as	ADP
dti-1400	53	78	a	a	DET
dti-1400	53	79	confounder	confounder	NOUN
dti-1400	53	80	of	of	ADP
dti-1400	53	81	the	the	DET
dti-1400	53	82	table	table	NOUN
dti-1400	53	83	1	1	NUM
dti-1400	53	84	.	.	PUNCT
dti-1400	53	85	changes	change	NOUN
dti-1400	53	86	in	in	ADP
dti-1400	53	87	the	the	DET
dti-1400	53	88	serum	serum	NOUN
dti-1400	53	89	acyclovir	acyclovir	PROPN
dti-1400	53	90	levels	level	VERB
dti-1400	53	91	just	just	ADV
dti-1400	53	92	before	before	ADP
dti-1400	53	93	and	and	CCONJ
dti-1400	53	94	after	after	ADP
dti-1400	53	95	the	the	DET
dti-1400	53	96	blood	blood	NOUN
dti-1400	53	97	purification	purification	NOUN
dti-1400	53	98	procedures	procedure	NOUN
dti-1400	53	99	.	.	PUNCT
dti-1400	54	1	hospital	hospital	NOUN
dti-1400	54	2	day	day	PROPN
dti-1400	54	3	mode	mode	NOUN
dti-1400	54	4	of	of	ADP
dti-1400	54	5	blood	blood	NOUN
dti-1400	54	6	purification	purification	NOUN
dti-1400	54	7	serum	serum	NOUN
dti-1400	54	8	acyclovir	acyclovir	PROPN
dti-1400	54	9	level	level	PROPN
dti-1400	54	10	,	,	PUNCT
dti-1400	54	11	μg	μg	PROPN
dti-1400	54	12	/	/	SYM
dti-1400	54	13	ml	ml	NOUN
dti-1400	54	14	before	before	ADP
dti-1400	54	15	the	the	DET
dti-1400	54	16	procedure	procedure	NOUN
dti-1400	54	17	after	after	ADP
dti-1400	54	18	the	the	DET
dti-1400	54	19	procedure	procedure	NOUN
dti-1400	54	20	1	1	NUM
dti-1400	54	21	hf	hf	ADP
dti-1400	54	22	26.9	26.9	NUM
dti-1400	54	23	na	na	PART
dti-1400	54	24	2	2	NUM
dti-1400	54	25	hp	hp	PROPN
dti-1400	54	26	15.88	15.88	NUM
dti-1400	54	27	na	na	PART
dti-1400	54	28	3	3	NUM
dti-1400	54	29	hd	hd	VERB
dti-1400	54	30	4.72	4.72	NUM
dti-1400	54	31	1.95	1.95	NUM
dti-1400	54	32	5	5	NUM
dti-1400	54	33	hd	hd	VERB
dti-1400	54	34	na	na	ADP
dti-1400	54	35	0.43	0.43	NUM
dti-1400	54	36	abbreviations	abbreviation	NOUN
dti-1400	54	37	:	:	PUNCT
dti-1400	54	38	na	na	NOUN
dti-1400	54	39	:	:	PUNCT
dti-1400	54	40	not	not	PART
dti-1400	54	41	available	available	ADJ
dti-1400	54	42	.	.	PUNCT
dti-1400	55	1	4	4	NUM
dti-1400	55	2	drug	drug	NOUN
dti-1400	55	3	target	target	NOUN
dti-1400	55	4	insights	insight	NOUN
dti-1400	55	5	valacyclovir	valacyclovir	ADV
dti-1400	55	6	-	-	PUNCT
dti-1400	55	7	mediated	mediate	VERB
dti-1400	55	8	depression	depression	NOUN
dti-1400	55	9	of	of	ADP
dti-1400	55	10	the	the	DET
dti-1400	55	11	patient	patient	NOUN
dti-1400	55	12	’s	’s	PART
dti-1400	55	13	consciousness	consciousness	NOUN
dti-1400	55	14	as	as	ADP
dti-1400	55	15	the	the	DET
dti-1400	55	16	clinical	clinical	ADJ
dti-1400	55	17	manifestations	manifestation	NOUN
dti-1400	55	18	of	of	ADP
dti-1400	55	19	hyponatremia	hyponatremia	NOUN
dti-1400	55	20	are	be	AUX
dti-1400	55	21	primarily	primarily	ADV
dti-1400	55	22	neurological26	neurological26	ADJ
dti-1400	55	23	;	;	PUNCT
dti-1400	55	24	however	however	ADV
dti-1400	55	25	,	,	PUNCT
dti-1400	55	26	it	it	PRON
dti-1400	55	27	is	be	AUX
dti-1400	55	28	difficult	difficult	ADJ
dti-1400	55	29	to	to	PART
dti-1400	55	30	determine	determine	VERB
dti-1400	55	31	the	the	DET
dti-1400	55	32	precise	precise	ADJ
dti-1400	55	33	contributions	contribution	NOUN
dti-1400	55	34	of	of	ADP
dti-1400	55	35	each	each	DET
dti-1400	55	36	factor	factor	NOUN
dti-1400	55	37	.	.	PUNCT
dti-1400	56	1	valacyclovir	valacyclovir	PROPN
dti-1400	56	2	or	or	CCONJ
dti-1400	56	3	acyclovir	acyclovir	PROPN
dti-1400	56	4	neurotoxicity	neurotoxicity	PROPN
dti-1400	56	5	commonly	commonly	ADV
dti-1400	56	6	develops	develop	VERB
dti-1400	56	7	in	in	ADP
dti-1400	56	8	patients	patient	NOUN
dti-1400	56	9	with	with	ADP
dti-1400	56	10	an	an	DET
dti-1400	56	11	impaired	impaired	ADJ
dti-1400	56	12	renal	renal	ADJ
dti-1400	56	13	function	function	NOUN
dti-1400	56	14	,	,	PUNCT
dti-1400	56	15	implying	imply	VERB
dti-1400	56	16	a	a	DET
dti-1400	56	17	role	role	NOUN
dti-1400	56	18	of	of	ADP
dti-1400	56	19	a	a	DET
dti-1400	56	20	declined	decline	VERB
dti-1400	56	21	renal	renal	ADJ
dti-1400	56	22	clearance	clearance	NOUN
dti-1400	56	23	–	–	PUNCT
dti-1400	56	24	mediated	mediate	VERB
dti-1400	56	25	accumulation	accumulation	NOUN
dti-1400	56	26	of	of	ADP
dti-1400	56	27	acyclovir	acyclovir	PROPN
dti-1400	56	28	and/or	and/or	CCONJ
dti-1400	56	29	its	its	PRON
dti-1400	56	30	metabolites	metabolite	NOUN
dti-1400	56	31	in	in	ADP
dti-1400	56	32	the	the	DET
dti-1400	56	33	bloodstream.3,4	bloodstream.3,4	PROPN
dti-1400	56	34	given	give	VERB
dti-1400	56	35	that	that	SCONJ
dti-1400	56	36	the	the	DET
dti-1400	56	37	renal	renal	ADJ
dti-1400	56	38	clearance	clearance	NOUN
dti-1400	56	39	of	of	ADP
dti-1400	56	40	acyclovir	acyclovir	PROPN
dti-1400	56	41	absolutely	absolutely	ADV
dti-1400	56	42	exceeds	exceed	VERB
dti-1400	56	43	that	that	PRON
dti-1400	56	44	of	of	ADP
dti-1400	56	45	creatinine	creatinine	NOUN
dti-1400	56	46	,	,	PUNCT
dti-1400	56	47	indicating	indicate	VERB
dti-1400	56	48	that	that	SCONJ
dti-1400	56	49	renal	renal	ADJ
dti-1400	56	50	tubular	tubular	ADJ
dti-1400	56	51	secretion	secretion	NOUN
dti-1400	56	52	is	be	AUX
dti-1400	56	53	actively	actively	ADV
dti-1400	56	54	involved	involve	VERB
dti-1400	56	55	in	in	ADP
dti-1400	56	56	the	the	DET
dti-1400	56	57	elimination	elimination	NOUN
dti-1400	56	58	of	of	ADP
dti-1400	56	59	the	the	DET
dti-1400	56	60	agent,1	agent,1	NOUN
dti-1400	56	61	it	it	PRON
dti-1400	56	62	is	be	AUX
dti-1400	56	63	not	not	PART
dti-1400	56	64	surprising	surprising	ADJ
dti-1400	56	65	that	that	SCONJ
dti-1400	56	66	acyclovir	acyclovir	PROPN
dti-1400	56	67	can	can	AUX
dti-1400	56	68	induce	induce	VERB
dti-1400	56	69	renal	renal	ADJ
dti-1400	56	70	failure	failure	NOUN
dti-1400	56	71	through	through	ADP
dti-1400	56	72	precipitation	precipitation	NOUN
dti-1400	56	73	within	within	ADP
dti-1400	56	74	the	the	DET
dti-1400	56	75	tubular	tubular	ADJ
dti-1400	56	76	lumen	luman	NOUN
dti-1400	56	77	,	,	PUNCT
dti-1400	56	78	which	which	PRON
dti-1400	56	79	leads	lead	VERB
dti-1400	56	80	to	to	AUX
dti-1400	56	81	obstructive	obstructive	VERB
dti-1400	56	82	nephropathy.2,8	nephropathy.2,8	PROPN
dti-1400	56	83	in	in	ADP
dti-1400	56	84	rare	rare	ADJ
dti-1400	56	85	instances	instance	NOUN
dti-1400	56	86	,	,	PUNCT
dti-1400	56	87	interstitial	interstitial	ADJ
dti-1400	56	88	nephritis	nephritis	NOUN
dti-1400	56	89	and	and	CCONJ
dti-1400	56	90	direct	direct	ADJ
dti-1400	56	91	tubular	tubular	ADJ
dti-1400	56	92	necrosis	necrosis	NOUN
dti-1400	56	93	from	from	ADP
dti-1400	56	94	acyclovir	acyclovir	PROPN
dti-1400	56	95	may	may	AUX
dti-1400	56	96	also	also	ADV
dti-1400	56	97	result	result	VERB
dti-1400	56	98	in	in	ADP
dti-1400	56	99	renal	renal	ADJ
dti-1400	56	100	insufficiency.2,3,8	insufficiency.2,3,8	X
dti-1400	56	101	alternatively	alternatively	ADV
dti-1400	56	102	,	,	PUNCT
dti-1400	56	103	or	or	CCONJ
dti-1400	56	104	in	in	ADP
dti-1400	56	105	addition	addition	NOUN
dti-1400	56	106	,	,	PUNCT
dti-1400	56	107	the	the	DET
dti-1400	56	108	gfr	gfr	NOUN
dti-1400	56	109	may	may	AUX
dti-1400	56	110	decline	decline	VERB
dti-1400	56	111	due	due	ADJ
dti-1400	56	112	to	to	ADP
dti-1400	56	113	an	an	DET
dti-1400	56	114	acyclovir	acyclovir	PROPN
dti-1400	56	115	-	-	PUNCT
dti-1400	56	116	mediated	mediate	VERB
dti-1400	56	117	increase	increase	NOUN
dti-1400	56	118	in	in	ADP
dti-1400	56	119	the	the	DET
dti-1400	56	120	total	total	ADJ
dti-1400	56	121	renal	renal	ADJ
dti-1400	56	122	vascular	vascular	ADJ
dti-1400	56	123	resistance	resistance	NOUN
dti-1400	56	124	with	with	ADP
dti-1400	56	125	a	a	DET
dti-1400	56	126	reduction	reduction	NOUN
dti-1400	56	127	in	in	ADP
dti-1400	56	128	the	the	DET
dti-1400	56	129	renal	renal	ADJ
dti-1400	56	130	plasma	plasma	NOUN
dti-1400	56	131	flow.2,11,27	flow.2,11,27	NOUN
dti-1400	56	132	the	the	DET
dti-1400	56	133	reason	reason	NOUN
dti-1400	56	134	why	why	SCONJ
dti-1400	56	135	adverse	adverse	ADJ
dti-1400	56	136	renal	renal	ADJ
dti-1400	56	137	events	event	NOUN
dti-1400	56	138	were	be	AUX
dti-1400	56	139	induced	induce	VERB
dti-1400	56	140	in	in	ADP
dti-1400	56	141	our	our	PRON
dti-1400	56	142	patient	patient	NOUN
dti-1400	56	143	remains	remain	VERB
dti-1400	56	144	to	to	PART
dti-1400	56	145	be	be	AUX
dti-1400	56	146	clarified	clarify	VERB
dti-1400	56	147	.	.	PUNCT
dti-1400	57	1	the	the	DET
dti-1400	57	2	patient	patient	NOUN
dti-1400	57	3	’s	’s	PART
dti-1400	57	4	prompt	prompt	ADJ
dti-1400	57	5	recovery	recovery	NOUN
dti-1400	57	6	from	from	ADP
dti-1400	57	7	aki	aki	NOUN
dti-1400	57	8	does	do	AUX
dti-1400	57	9	not	not	PART
dti-1400	57	10	support	support	VERB
dti-1400	57	11	the	the	DET
dti-1400	57	12	concurrent	concurrent	ADJ
dti-1400	57	13	presence	presence	NOUN
dti-1400	57	14	of	of	ADP
dti-1400	57	15	primary	primary	ADJ
dti-1400	57	16	and/or	and/or	CCONJ
dti-1400	57	17	secondary	secondary	ADJ
dti-1400	57	18	renal	renal	ADJ
dti-1400	57	19	parenchymal	parenchymal	ADJ
dti-1400	57	20	damage	damage	NOUN
dti-1400	57	21	.	.	PUNCT
dti-1400	58	1	instead	instead	ADV
dti-1400	58	2	,	,	PUNCT
dti-1400	58	3	we	we	PRON
dti-1400	58	4	believe	believe	VERB
dti-1400	58	5	that	that	SCONJ
dti-1400	58	6	the	the	DET
dti-1400	58	7	diminished	diminished	ADJ
dti-1400	58	8	kidney	kidney	NOUN
dti-1400	58	9	reserve	reserve	NOUN
dti-1400	58	10	resulting	result	VERB
dti-1400	58	11	from	from	ADP
dti-1400	58	12	age	age	NOUN
dti-1400	58	13	-	-	PUNCT
dti-1400	58	14	dependent	dependent	ADJ
dti-1400	58	15	functional	functional	ADJ
dti-1400	58	16	and	and	CCONJ
dti-1400	58	17	morphological	morphological	ADJ
dti-1400	58	18	changes	change	NOUN
dti-1400	58	19	with	with	ADP
dti-1400	58	20	a	a	DET
dti-1400	58	21	moderate	moderate	ADJ
dti-1400	58	22	reduction	reduction	NOUN
dti-1400	58	23	in	in	ADP
dti-1400	58	24	the	the	DET
dti-1400	58	25	gfr	gfr	NOUN
dti-1400	58	26	at	at	ADP
dti-1400	58	27	baseline	baseline	PROPN
dti-1400	58	28	was	be	AUX
dti-1400	58	29	likely	likely	ADJ
dti-1400	58	30	to	to	PART
dti-1400	58	31	have	have	AUX
dti-1400	58	32	played	play	VERB
dti-1400	58	33	a	a	DET
dti-1400	58	34	major	major	ADJ
dti-1400	58	35	role	role	NOUN
dti-1400	58	36	,	,	PUNCT
dti-1400	58	37	thereby	thereby	ADV
dti-1400	58	38	making	make	VERB
dti-1400	58	39	our	our	PRON
dti-1400	58	40	patient	patient	NOUN
dti-1400	58	41	vulnerable	vulnerable	ADJ
dti-1400	58	42	to	to	ADP
dti-1400	58	43	acute	acute	VERB
dti-1400	58	44	stress	stress	NOUN
dti-1400	58	45	from	from	ADP
dti-1400	58	46	the	the	DET
dti-1400	58	47	agent	agent	NOUN
dti-1400	58	48	and	and	CCONJ
dti-1400	58	49	more	more	ADV
dti-1400	58	50	likely	likely	ADJ
dti-1400	58	51	to	to	PART
dti-1400	58	52	develop	develop	VERB
dti-1400	58	53	clinically	clinically	ADV
dti-1400	58	54	relevant	relevant	ADJ
dti-1400	58	55	aki.28	aki.28	NOUN
dti-1400	58	56	unfavorably	unfavorably	ADV
dti-1400	58	57	modulated	modulate	VERB
dti-1400	58	58	renal	renal	ADJ
dti-1400	58	59	hemodynamics	hemodynamic	NOUN
dti-1400	58	60	induced	induce	VERB
dti-1400	58	61	by	by	ADP
dti-1400	58	62	the	the	DET
dti-1400	58	63	concurrent	concurrent	ADJ
dti-1400	58	64	use	use	NOUN
dti-1400	58	65	of	of	ADP
dti-1400	58	66	angiotensin	angiotensin	NOUN
dti-1400	58	67	ii	ii	PROPN
dti-1400	58	68	receptor	receptor	NOUN
dti-1400	58	69	antagonists	antagonist	NOUN
dti-1400	58	70	might	might	AUX
dti-1400	58	71	also	also	ADV
dti-1400	58	72	lay	lay	VERB
dti-1400	58	73	the	the	DET
dti-1400	58	74	groundwork	groundwork	NOUN
dti-1400	58	75	for	for	ADP
dti-1400	58	76	the	the	DET
dti-1400	58	77	development	development	NOUN
dti-1400	58	78	of	of	ADP
dti-1400	58	79	this	this	DET
dti-1400	58	80	disease.11,28	disease.11,28	NOUN
dti-1400	58	81	otherwise	otherwise	ADV
dti-1400	58	82	,	,	PUNCT
dti-1400	58	83	our	our	PRON
dti-1400	58	84	patient	patient	NOUN
dti-1400	58	85	might	might	AUX
dti-1400	58	86	have	have	AUX
dti-1400	58	87	received	receive	VERB
dti-1400	58	88	an	an	DET
dti-1400	58	89	inappropriately	inappropriately	ADV
dti-1400	58	90	high	high	ADJ
dti-1400	58	91	dose	dose	NOUN
dti-1400	58	92	of	of	ADP
dti-1400	58	93	valacyclovir	valacyclovir	NOUN
dti-1400	58	94	as	as	ADP
dti-1400	58	95	determining	determine	VERB
dti-1400	58	96	ecrcl	ecrcl	NOUN
dti-1400	58	97	with	with	ADP
dti-1400	58	98	scr	scr	NOUN
dti-1400	58	99	levels	level	NOUN
dti-1400	58	100	measured	measure	VERB
dti-1400	58	101	by	by	ADP
dti-1400	58	102	enzymatic	enzymatic	ADJ
dti-1400	58	103	but	but	CCONJ
dti-1400	58	104	not	not	PART
dti-1400	58	105	by	by	ADP
dti-1400	58	106	jaffe	jaffe	PROPN
dti-1400	58	107	assays	assay	NOUN
dti-1400	58	108	,	,	PUNCT
dti-1400	58	109	which	which	PRON
dti-1400	58	110	are	be	AUX
dti-1400	58	111	not	not	PART
dti-1400	58	112	common	common	ADJ
dti-1400	58	113	in	in	ADP
dti-1400	58	114	japan	japan	PROPN
dti-1400	58	115	,	,	PUNCT
dti-1400	58	116	without	without	ADP
dti-1400	58	117	standardization	standardization	NOUN
dti-1400	58	118	can	can	AUX
dti-1400	58	119	overestimate	overestimate	VERB
dti-1400	58	120	actual	actual	ADJ
dti-1400	58	121	gfr	gfr	NOUN
dti-1400	58	122	,	,	PUNCT
dti-1400	58	123	although	although	SCONJ
dti-1400	58	124	the	the	DET
dti-1400	58	125	optimum	optimum	ADJ
dti-1400	58	126	strategy	strategy	NOUN
dti-1400	58	127	for	for	ADP
dti-1400	58	128	solving	solve	VERB
dti-1400	58	129	this	this	DET
dti-1400	58	130	problem	problem	NOUN
dti-1400	58	131	remains	remain	VERB
dti-1400	58	132	to	to	PART
dti-1400	58	133	be	be	AUX
dti-1400	58	134	delineated.5,29,30	delineated.5,29,30	PROPN
dti-1400	58	135	the	the	DET
dti-1400	58	136	pathogenesis	pathogenesis	NOUN
dti-1400	58	137	of	of	ADP
dti-1400	58	138	valacyclovir	valacyclovir	PROPN
dti-1400	58	139	and/or	and/or	CCONJ
dti-1400	58	140	acyclovir	acyclovir	PROPN
dti-1400	58	141	neurotoxicity	neurotoxicity	PROPN
dti-1400	58	142	is	be	AUX
dti-1400	58	143	still	still	ADV
dti-1400	58	144	a	a	DET
dti-1400	58	145	matter	matter	NOUN
dti-1400	58	146	of	of	ADP
dti-1400	58	147	debate	debate	NOUN
dti-1400	58	148	.	.	PUNCT
dti-1400	59	1	although	although	SCONJ
dti-1400	59	2	a	a	DET
dti-1400	59	3	specific	specific	ADJ
dti-1400	59	4	therapeutic	therapeutic	ADJ
dti-1400	59	5	range	range	NOUN
dti-1400	59	6	has	have	AUX
dti-1400	59	7	not	not	PART
dti-1400	59	8	been	be	AUX
dti-1400	59	9	equivocally	equivocally	ADV
dti-1400	59	10	established	establish	VERB
dti-1400	59	11	,	,	PUNCT
dti-1400	59	12	these	these	DET
dti-1400	59	13	values	value	NOUN
dti-1400	59	14	overlap	overlap	VERB
dti-1400	59	15	with	with	ADP
dti-1400	59	16	the	the	DET
dti-1400	59	17	reported	report	VERB
dti-1400	59	18	trough	trough	NOUN
dti-1400	59	19	levels	level	NOUN
dti-1400	59	20	,	,	PUNCT
dti-1400	59	21	ranging	range	VERB
dti-1400	59	22	from	from	ADP
dti-1400	59	23	0.5	0.5	NUM
dti-1400	59	24	to	to	PART
dti-1400	59	25	3	3	NUM
dti-1400	59	26	μg	μg	PROPN
dti-1400	59	27	/	/	SYM
dti-1400	59	28	ml,31	ml,31	PROPN
dti-1400	59	29	whereas	whereas	SCONJ
dti-1400	59	30	peak	peak	VERB
dti-1400	59	31	concentrations	concentration	NOUN
dti-1400	59	32	of	of	ADP
dti-1400	59	33	approximately	approximately	ADV
dti-1400	59	34	5.6	5.6	NUM
dti-1400	59	35	μg	μg	NOUN
dti-1400	59	36	/	/	SYM
dti-1400	59	37	ml	ml	NOUN
dti-1400	59	38	and	and	CCONJ
dti-1400	59	39	trough	trough	NOUN
dti-1400	59	40	levels	level	NOUN
dti-1400	59	41	of	of	ADP
dti-1400	59	42	<	<	X
dti-1400	59	43	2	2	NUM
dti-1400	59	44	μg	μg	NOUN
dti-1400	59	45	/	/	SYM
dti-1400	59	46	ml	ml	PROPN
dti-1400	59	47	may	may	AUX
dti-1400	59	48	be	be	AUX
dti-1400	59	49	efficacious	efficacious	ADJ
dti-1400	59	50	and	and	CCONJ
dti-1400	59	51	below	below	ADP
dti-1400	59	52	the	the	DET
dti-1400	59	53	concentrations	concentration	NOUN
dti-1400	59	54	at	at	ADP
dti-1400	59	55	which	which	PRON
dti-1400	59	56	acyclovir	acyclovir	PROPN
dti-1400	59	57	displays	display	VERB
dti-1400	59	58	apparent	apparent	ADJ
dti-1400	59	59	neurotoxicity.1,11,32	neurotoxicity.1,11,32	ADJ
dti-1400	59	60	acyclovir	acyclovir	PROPN
dti-1400	59	61	slowly	slowly	ADV
dti-1400	59	62	crosses	cross	VERB
dti-1400	59	63	the	the	DET
dti-1400	59	64	blood	blood	NOUN
dti-1400	59	65	-	-	PUNCT
dti-1400	59	66	brain	brain	NOUN
dti-1400	59	67	barrier	barrier	NOUN
dti-1400	59	68	and	and	CCONJ
dti-1400	59	69	is	be	AUX
dti-1400	59	70	then	then	ADV
dti-1400	59	71	actively	actively	ADV
dti-1400	59	72	transported	transport	VERB
dti-1400	59	73	out	out	ADP
dti-1400	59	74	of	of	ADP
dti-1400	59	75	the	the	DET
dti-1400	59	76	csf	csf	ADJ
dti-1400	59	77	compartment.33	compartment.33	PROPN
dti-1400	59	78	however	however	ADV
dti-1400	59	79	,	,	PUNCT
dti-1400	59	80	the	the	DET
dti-1400	59	81	impact	impact	NOUN
dti-1400	59	82	of	of	ADP
dti-1400	59	83	the	the	DET
dti-1400	59	84	acyclovir	acyclovir	PROPN
dti-1400	59	85	on	on	ADP
dti-1400	59	86	the	the	DET
dti-1400	59	87	pathogenesis	pathogenesis	NOUN
dti-1400	59	88	of	of	ADP
dti-1400	59	89	neurotoxicity	neurotoxicity	NOUN
dti-1400	59	90	remains	remain	VERB
dti-1400	59	91	to	to	PART
dti-1400	59	92	be	be	AUX
dti-1400	59	93	determined	determine	VERB
dti-1400	59	94	because	because	SCONJ
dti-1400	59	95	its	its	PRON
dti-1400	59	96	serum	serum	NOUN
dti-1400	59	97	levels	level	NOUN
dti-1400	59	98	are	be	AUX
dti-1400	59	99	not	not	PART
dti-1400	59	100	necessarily	necessarily	ADV
dti-1400	59	101	above	above	ADP
dti-1400	59	102	the	the	DET
dti-1400	59	103	therapeutic	therapeutic	ADJ
dti-1400	59	104	range	range	NOUN
dti-1400	59	105	in	in	ADP
dti-1400	59	106	patients	patient	NOUN
dti-1400	59	107	presenting	present	VERB
dti-1400	59	108	with	with	ADP
dti-1400	59	109	neuropsychiatric	neuropsychiatric	ADJ
dti-1400	59	110	manifestations.4,34	manifestations.4,34	PROPN
dti-1400	59	111	rather	rather	ADV
dti-1400	59	112	,	,	PUNCT
dti-1400	59	113	we	we	PRON
dti-1400	59	114	may	may	AUX
dti-1400	59	115	need	need	VERB
dti-1400	59	116	to	to	PART
dti-1400	59	117	focus	focus	VERB
dti-1400	59	118	on	on	ADP
dti-1400	59	119	9	9	NUM
dti-1400	59	120	-	-	PUNCT
dti-1400	59	121	carboxymethoxymethylguanine	carboxymethoxymethylguanine	NOUN
dti-1400	59	122	(	(	PUNCT
dti-1400	59	123	cmmg	cmmg	PROPN
dti-1400	59	124	)	)	PUNCT
dti-1400	59	125	,	,	PUNCT
dti-1400	59	126	a	a	DET
dti-1400	59	127	major	major	ADJ
dti-1400	59	128	metabolite	metabolite	NOUN
dti-1400	59	129	of	of	ADP
dti-1400	59	130	acyclovir	acyclovir	PROPN
dti-1400	59	131	,	,	PUNCT
dti-1400	59	132	as	as	ADP
dti-1400	59	133	a	a	DET
dti-1400	59	134	candidate	candidate	NOUN
dti-1400	59	135	offender	offender	NOUN
dti-1400	59	136	as	as	SCONJ
dti-1400	59	137	it	it	PRON
dti-1400	59	138	has	have	AUX
dti-1400	59	139	been	be	AUX
dti-1400	59	140	regarded	regard	VERB
dti-1400	59	141	as	as	ADP
dti-1400	59	142	a	a	DET
dti-1400	59	143	significant	significant	ADJ
dti-1400	59	144	reliable	reliable	ADJ
dti-1400	59	145	predictor	predictor	NOUN
dti-1400	59	146	of	of	ADP
dti-1400	59	147	developing	develop	VERB
dti-1400	59	148	neuropsychiatric	neuropsychiatric	ADJ
dti-1400	59	149	events	event	NOUN
dti-1400	59	150	during	during	ADP
dti-1400	59	151	acyclovir	acyclovir	PROPN
dti-1400	59	152	treatment.4,35	treatment.4,35	PROPN
dti-1400	59	153	not	not	PART
dti-1400	59	154	surprisingly	surprisingly	ADV
dti-1400	59	155	,	,	PUNCT
dti-1400	59	156	the	the	DET
dti-1400	59	157	determination	determination	NOUN
dti-1400	59	158	of	of	ADP
dti-1400	59	159	serum	serum	NOUN
dti-1400	59	160	levels	level	NOUN
dti-1400	59	161	of	of	ADP
dti-1400	59	162	cmmg	cmmg	PROPN
dti-1400	59	163	may	may	AUX
dti-1400	59	164	also	also	ADV
dti-1400	59	165	be	be	AUX
dti-1400	59	166	a	a	DET
dti-1400	59	167	useful	useful	ADJ
dti-1400	59	168	diagnostic	diagnostic	ADJ
dti-1400	59	169	tool	tool	NOUN
dti-1400	59	170	for	for	ADP
dti-1400	59	171	valacyclovir	valacyclovir	PROPN
dti-1400	59	172	and/or	and/or	CCONJ
dti-1400	59	173	acyclovir	acyclovir	VERB
dti-1400	59	174	neurotoxicity,35	neurotoxicity,35	NOUN
dti-1400	59	175	although	although	SCONJ
dti-1400	59	176	such	such	DET
dti-1400	59	177	a	a	DET
dti-1400	59	178	procedure	procedure	NOUN
dti-1400	59	179	was	be	AUX
dti-1400	59	180	not	not	PART
dti-1400	59	181	applicable	applicable	ADJ
dti-1400	59	182	in	in	ADP
dti-1400	59	183	the	the	DET
dti-1400	59	184	current	current	ADJ
dti-1400	59	185	patient	patient	NOUN
dti-1400	59	186	.	.	PUNCT
dti-1400	60	1	the	the	DET
dti-1400	60	2	cumulative	cumulative	ADJ
dti-1400	60	3	number	number	NOUN
dti-1400	60	4	of	of	ADP
dti-1400	60	5	publications	publication	NOUN
dti-1400	60	6	on	on	ADP
dti-1400	60	7	these	these	DET
dti-1400	60	8	topics	topic	NOUN
dti-1400	60	9	has	have	AUX
dti-1400	60	10	been	be	AUX
dti-1400	60	11	steadily	steadily	ADV
dti-1400	60	12	growing2–4,8–15	growing2–4,8–15	PROPN
dti-1400	60	13	;	;	PUNCT
dti-1400	60	14	however	however	ADV
dti-1400	60	15	,	,	PUNCT
dti-1400	60	16	we	we	PRON
dti-1400	60	17	are	be	AUX
dti-1400	60	18	of	of	ADP
dti-1400	60	19	the	the	DET
dti-1400	60	20	opinion	opinion	NOUN
dti-1400	60	21	that	that	SCONJ
dti-1400	60	22	awareness	awareness	NOUN
dti-1400	60	23	of	of	ADP
dti-1400	60	24	this	this	DET
dti-1400	60	25	pathology	pathology	NOUN
dti-1400	60	26	remains	remain	VERB
dti-1400	60	27	limited	limited	ADJ
dti-1400	60	28	and	and	CCONJ
dti-1400	60	29	that	that	SCONJ
dti-1400	60	30	an	an	DET
dti-1400	60	31	early	early	ADJ
dti-1400	60	32	diagnosis	diagnosis	NOUN
dti-1400	60	33	remains	remain	VERB
dti-1400	60	34	a	a	DET
dti-1400	60	35	challenge	challenge	NOUN
dti-1400	60	36	for	for	ADP
dti-1400	60	37	the	the	DET
dti-1400	60	38	physicians	physician	NOUN
dti-1400	60	39	in	in	ADP
dti-1400	60	40	the	the	DET
dti-1400	60	41	ordinary	ordinary	ADJ
dti-1400	60	42	clinical	clinical	ADJ
dti-1400	60	43	settings	setting	NOUN
dti-1400	60	44	.	.	PUNCT
dti-1400	61	1	needless	needless	ADJ
dti-1400	61	2	to	to	PART
dti-1400	61	3	say	say	VERB
dti-1400	61	4	,	,	PUNCT
dti-1400	61	5	it	it	PRON
dti-1400	61	6	is	be	AUX
dti-1400	61	7	important	important	ADJ
dti-1400	61	8	to	to	PART
dti-1400	61	9	consider	consider	VERB
dti-1400	61	10	how	how	SCONJ
dti-1400	61	11	to	to	PART
dti-1400	61	12	prevent	prevent	VERB
dti-1400	61	13	the	the	DET
dti-1400	61	14	adverse	adverse	ADJ
dti-1400	61	15	events	event	NOUN
dti-1400	61	16	associated	associate	VERB
dti-1400	61	17	with	with	ADP
dti-1400	61	18	valacyclovir	valacyclovir	PROPN
dti-1400	61	19	and/or	and/or	CCONJ
dti-1400	61	20	acyclovir	acyclovir	PROPN
dti-1400	61	21	that	that	PRON
dti-1400	61	22	were	be	AUX
dti-1400	61	23	described	describe	VERB
dti-1400	61	24	in	in	ADP
dti-1400	61	25	this	this	DET
dti-1400	61	26	study	study	NOUN
dti-1400	61	27	.	.	PUNCT
dti-1400	62	1	some	some	DET
dti-1400	62	2	possible	possible	ADJ
dti-1400	62	3	approaches	approach	NOUN
dti-1400	62	4	include	include	VERB
dti-1400	62	5	establishing	establish	VERB
dti-1400	62	6	a	a	DET
dti-1400	62	7	euvolemic	euvolemic	ADJ
dti-1400	62	8	state	state	NOUN
dti-1400	62	9	before	before	ADP
dti-1400	62	10	the	the	DET
dti-1400	62	11	administration	administration	NOUN
dti-1400	62	12	of	of	ADP
dti-1400	62	13	the	the	DET
dti-1400	62	14	medication	medication	NOUN
dti-1400	62	15	,	,	PUNCT
dti-1400	62	16	slower	slow	ADJ
dti-1400	62	17	drug	drug	NOUN
dti-1400	62	18	infusion	infusion	NOUN
dti-1400	62	19	,	,	PUNCT
dti-1400	62	20	dose	dose	NOUN
dti-1400	62	21	adjustment	adjustment	NOUN
dti-1400	62	22	according	accord	VERB
dti-1400	62	23	to	to	ADP
dti-1400	62	24	the	the	DET
dti-1400	62	25	renal	renal	ADJ
dti-1400	62	26	function	function	NOUN
dti-1400	62	27	,	,	PUNCT
dti-1400	62	28	and	and	CCONJ
dti-1400	62	29	avoiding	avoid	VERB
dti-1400	62	30	the	the	DET
dti-1400	62	31	use	use	NOUN
dti-1400	62	32	of	of	ADP
dti-1400	62	33	other	other	ADJ
dti-1400	62	34	nephrotoxic	nephrotoxic	ADJ
dti-1400	62	35	agents.2,36	agents.2,36	NUM
dti-1400	62	36	the	the	DET
dti-1400	62	37	published	publish	VERB
dti-1400	62	38	literature	literature	NOUN
dti-1400	62	39	lacks	lack	VERB
dti-1400	62	40	information	information	NOUN
dti-1400	62	41	on	on	ADP
dti-1400	62	42	the	the	DET
dti-1400	62	43	safety	safety	NOUN
dti-1400	62	44	of	of	ADP
dti-1400	62	45	substitution	substitution	NOUN
dti-1400	62	46	with	with	ADP
dti-1400	62	47	other	other	ADJ
dti-1400	62	48	antiviral	antiviral	ADJ
dti-1400	62	49	agents	agent	NOUN
dti-1400	62	50	;	;	PUNCT
dti-1400	62	51	however	however	ADV
dti-1400	62	52	,	,	PUNCT
dti-1400	62	53	it	it	PRON
dti-1400	62	54	has	have	AUX
dti-1400	62	55	been	be	AUX
dti-1400	62	56	proposed	propose	VERB
dti-1400	62	57	anecdotally	anecdotally	ADV
dti-1400	62	58	that	that	SCONJ
dti-1400	62	59	famciclovir	famciclovir	PROPN
dti-1400	62	60	may	may	AUX
dti-1400	62	61	be	be	AUX
dti-1400	62	62	a	a	DET
dti-1400	62	63	candidate	candidate	NOUN
dti-1400	62	64	for	for	ADP
dti-1400	62	65	substitution	substitution	NOUN
dti-1400	62	66	—	—	PUNCT
dti-1400	62	67	at	at	ADP
dti-1400	62	68	least	least	ADJ
dti-1400	62	69	in	in	ADP
dti-1400	62	70	patients	patient	NOUN
dti-1400	62	71	who	who	PRON
dti-1400	62	72	develop	develop	VERB
dti-1400	62	73	nephrotoxicity.37,38	nephrotoxicity.37,38	NOUN
dti-1400	62	74	however	however	ADV
dti-1400	62	75	,	,	PUNCT
dti-1400	62	76	famciclovir	famciclovir	PROPN
dti-1400	62	77	treatment	treatment	NOUN
dti-1400	62	78	may	may	AUX
dti-1400	62	79	still	still	ADV
dti-1400	62	80	be	be	AUX
dti-1400	62	81	associated	associate	VERB
dti-1400	62	82	with	with	ADP
dti-1400	62	83	some	some	DET
dti-1400	62	84	risk	risk	NOUN
dti-1400	62	85	of	of	ADP
dti-1400	62	86	neuropsychiatric	neuropsychiatric	ADJ
dti-1400	62	87	events.39	events.39	NOUN
dti-1400	62	88	finally	finally	ADV
dti-1400	62	89	,	,	PUNCT
dti-1400	62	90	we	we	PRON
dti-1400	62	91	strongly	strongly	ADV
dti-1400	62	92	recommend	recommend	VERB
dti-1400	62	93	the	the	DET
dti-1400	62	94	accumulation	accumulation	NOUN
dti-1400	62	95	of	of	ADP
dti-1400	62	96	more	more	ADJ
dti-1400	62	97	cases	case	NOUN
dti-1400	62	98	similar	similar	ADJ
dti-1400	62	99	to	to	ADP
dti-1400	62	100	our	our	PRON
dti-1400	62	101	own	own	ADJ
dti-1400	62	102	,	,	PUNCT
dti-1400	62	103	thereby	thereby	ADV
dti-1400	62	104	allowing	allow	VERB
dti-1400	62	105	us	we	PRON
dti-1400	62	106	to	to	PART
dti-1400	62	107	clarify	clarify	VERB
dti-1400	62	108	the	the	DET
dti-1400	62	109	nature	nature	NOUN
dti-1400	62	110	of	of	ADP
dti-1400	62	111	adverse	adverse	ADJ
dti-1400	62	112	valacyclovir	valacyclovir	NOUN
dti-1400	62	113	-	-	PUNCT
dti-1400	62	114	mediated	mediate	VERB
dti-1400	62	115	reactions	reaction	NOUN
dti-1400	62	116	more	more	ADV
dti-1400	62	117	precisely	precisely	ADV
dti-1400	62	118	as	as	ADV
dti-1400	62	119	well	well	ADV
dti-1400	62	120	as	as	ADP
dti-1400	62	121	establish	establish	VERB
dti-1400	62	122	an	an	DET
dti-1400	62	123	optimum	optimum	ADJ
dti-1400	62	124	management	management	NOUN
dti-1400	62	125	strategy	strategy	NOUN
dti-1400	62	126	,	,	PUNCT
dti-1400	62	127	especially	especially	ADV
dti-1400	62	128	regarding	regard	VERB
dti-1400	62	129	appropriate	appropriate	ADJ
dti-1400	62	130	valacyclovir	valacyclovir	NOUN
dti-1400	62	131	dosing	dose	VERB
dti-1400	62	132	regimens	regimen	NOUN
dti-1400	62	133	in	in	ADP
dti-1400	62	134	elderly	elderly	ADJ
dti-1400	62	135	patients	patient	NOUN
dti-1400	62	136	with	with	ADP
dti-1400	62	137	hz	hz	PROPN
dti-1400	62	138	who	who	PRON
dti-1400	62	139	barely	barely	ADV
dti-1400	62	140	appear	appear	VERB
dti-1400	62	141	to	to	PART
dti-1400	62	142	have	have	VERB
dti-1400	62	143	a	a	DET
dti-1400	62	144	favorable	favorable	ADJ
dti-1400	62	145	renal	renal	ADJ
dti-1400	62	146	function	function	NOUN
dti-1400	62	147	.	.	PUNCT
dti-1400	63	1	author	author	NOUN
dti-1400	63	2	contributions	contribution	NOUN
dti-1400	63	3	tmurakami	tmurakami	NOUN
dti-1400	63	4	and	and	CCONJ
dti-1400	63	5	ta	ta	AUX
dti-1400	63	6	drafted	draft	VERB
dti-1400	63	7	the	the	DET
dti-1400	63	8	manuscript	manuscript	NOUN
dti-1400	63	9	.	.	PUNCT
dti-1400	64	1	mo	mo	PROPN
dti-1400	64	2	,	,	PUNCT
dti-1400	64	3	eh	eh	INTJ
dti-1400	64	4	,	,	PUNCT
dti-1400	64	5	ts	ts	NOUN
dti-1400	64	6	,	,	PUNCT
dti-1400	64	7	am	be	AUX
dti-1400	64	8	,	,	PUNCT
dti-1400	64	9	mk	mk	PROPN
dti-1400	64	10	,	,	PUNCT
dti-1400	64	11	hy	hy	PROPN
dti-1400	64	12	,	,	PUNCT
dti-1400	64	13	and	and	CCONJ
dti-1400	64	14	tmasuda	tmasuda	NOUN
dti-1400	64	15	made	make	VERB
dti-1400	64	16	contributions	contribution	NOUN
dti-1400	64	17	to	to	ADP
dti-1400	64	18	the	the	DET
dti-1400	64	19	acquisition	acquisition	NOUN
dti-1400	64	20	of	of	ADP
dti-1400	64	21	the	the	DET
dti-1400	64	22	clinical	clinical	ADJ
dti-1400	64	23	data	datum	NOUN
dti-1400	64	24	.	.	PUNCT
dti-1400	65	1	tk	tk	PROPN
dti-1400	65	2	,	,	PUNCT
dti-1400	65	3	os	os	NOUN
dti-1400	65	4	,	,	PUNCT
dti-1400	65	5	sm	sm	PROPN
dti-1400	65	6	,	,	PUNCT
dti-1400	65	7	and	and	CCONJ
dti-1400	65	8	dn	dn	NOUN
dti-1400	65	9	provided	provide	VERB
dti-1400	65	10	a	a	DET
dti-1400	65	11	detailed	detailed	ADJ
dti-1400	65	12	review	review	NOUN
dti-1400	65	13	of	of	ADP
dti-1400	65	14	the	the	DET
dti-1400	65	15	contents	content	NOUN
dti-1400	65	16	and	and	CCONJ
dti-1400	65	17	structure	structure	NOUN
dti-1400	65	18	of	of	ADP
dti-1400	65	19	the	the	DET
dti-1400	65	20	manuscript	manuscript	NOUN
dti-1400	65	21	,	,	PUNCT
dti-1400	65	22	resulting	result	VERB
dti-1400	65	23	in	in	ADP
dti-1400	65	24	significant	significant	ADJ
dti-1400	65	25	changes	change	NOUN
dti-1400	65	26	to	to	ADP
dti-1400	65	27	the	the	DET
dti-1400	65	28	original	original	ADJ
dti-1400	65	29	document	document	NOUN
dti-1400	65	30	.	.	PUNCT
dti-1400	66	1	all	all	DET
dti-1400	66	2	authors	author	NOUN
dti-1400	66	3	have	have	AUX
dti-1400	66	4	read	read	VERB
dti-1400	66	5	and	and	CCONJ
dti-1400	66	6	approved	approve	VERB
dti-1400	66	7	the	the	DET
dti-1400	66	8	final	final	ADJ
dti-1400	66	9	manuscript	manuscript	NOUN
dti-1400	66	10	.	.	PUNCT
dti-1400	67	1	disclosure	disclosure	NOUN
dti-1400	67	2	and	and	CCONJ
dti-1400	67	3	ethics	ethic	NOUN
dti-1400	67	4	as	as	ADP
dti-1400	67	5	a	a	DET
dti-1400	67	6	requirement	requirement	NOUN
dti-1400	67	7	of	of	ADP
dti-1400	67	8	publication	publication	NOUN
dti-1400	67	9	,	,	PUNCT
dti-1400	67	10	the	the	DET
dti-1400	67	11	authors	author	NOUN
dti-1400	67	12	have	have	AUX
dti-1400	67	13	provided	provide	VERB
dti-1400	67	14	the	the	DET
dti-1400	67	15	publisher	publisher	NOUN
dti-1400	67	16	with	with	ADP
dti-1400	67	17	a	a	DET
dti-1400	67	18	signed	sign	VERB
dti-1400	67	19	confirmation	confirmation	NOUN
dti-1400	67	20	of	of	ADP
dti-1400	67	21	compliance	compliance	NOUN
dti-1400	67	22	with	with	ADP
dti-1400	67	23	legal	legal	ADJ
dti-1400	67	24	and	and	CCONJ
dti-1400	67	25	ethical	ethical	ADJ
dti-1400	67	26	obligations	obligation	NOUN
dti-1400	67	27	,	,	PUNCT
dti-1400	67	28	including	include	VERB
dti-1400	67	29	but	but	CCONJ
dti-1400	67	30	not	not	PART
dti-1400	67	31	limited	limit	VERB
dti-1400	67	32	to	to	ADP
dti-1400	67	33	the	the	DET
dti-1400	67	34	following	following	NOUN
dti-1400	67	35	:	:	PUNCT
dti-1400	67	36	authorship	authorship	NOUN
dti-1400	67	37	and	and	CCONJ
dti-1400	67	38	contributorship	contributorship	NOUN
dti-1400	67	39	,	,	PUNCT
dti-1400	67	40	conflicts	conflict	NOUN
dti-1400	67	41	of	of	ADP
dti-1400	67	42	interest	interest	NOUN
dti-1400	67	43	,	,	PUNCT
dti-1400	67	44	privacy	privacy	NOUN
dti-1400	67	45	and	and	CCONJ
dti-1400	67	46	confidentiality	confidentiality	NOUN
dti-1400	67	47	,	,	PUNCT
dti-1400	67	48	and	and	CCONJ
dti-1400	67	49	(	(	PUNCT
dti-1400	67	50	where	where	SCONJ
dti-1400	67	51	applicable	applicable	ADJ
dti-1400	67	52	)	)	PUNCT
dti-1400	67	53	protection	protection	NOUN
dti-1400	67	54	of	of	ADP
dti-1400	67	55	human	human	ADJ
dti-1400	67	56	and	and	CCONJ
dti-1400	67	57	animal	animal	NOUN
dti-1400	67	58	research	research	NOUN
dti-1400	67	59	subjects	subject	NOUN
dti-1400	67	60	.	.	PUNCT
dti-1400	68	1	the	the	DET
dti-1400	68	2	authors	author	NOUN
dti-1400	68	3	have	have	AUX
dti-1400	68	4	read	read	VERB
dti-1400	68	5	and	and	CCONJ
dti-1400	68	6	confirmed	confirm	VERB
dti-1400	68	7	their	their	PRON
dti-1400	68	8	agreement	agreement	NOUN
dti-1400	68	9	with	with	ADP
dti-1400	68	10	the	the	DET
dti-1400	68	11	icmje	icmje	NOUN
dti-1400	68	12	authorship	authorship	NOUN
dti-1400	68	13	and	and	CCONJ
dti-1400	68	14	conflict	conflict	NOUN
dti-1400	68	15	of	of	ADP
dti-1400	68	16	interest	interest	NOUN
dti-1400	68	17	criteria	criterion	NOUN
dti-1400	68	18	.	.	PUNCT
dti-1400	69	1	the	the	DET
dti-1400	69	2	authors	author	NOUN
dti-1400	69	3	have	have	AUX
dti-1400	69	4	also	also	ADV
dti-1400	69	5	confirmed	confirm	VERB
dti-1400	69	6	that	that	SCONJ
dti-1400	69	7	this	this	DET
dti-1400	69	8	article	article	NOUN
dti-1400	69	9	is	be	AUX
dti-1400	69	10	unique	unique	ADJ
dti-1400	69	11	and	and	CCONJ
dti-1400	69	12	that	that	SCONJ
dti-1400	69	13	it	it	PRON
dti-1400	69	14	is	be	AUX
dti-1400	69	15	not	not	PART
dti-1400	69	16	been	be	AUX
dti-1400	69	17	published	publish	VERB
dti-1400	69	18	nor	nor	CCONJ
dti-1400	69	19	is	be	AUX
dti-1400	69	20	it	it	PRON
dti-1400	69	21	under	under	ADP
dti-1400	69	22	consideration	consideration	NOUN
dti-1400	69	23	by	by	ADP
dti-1400	69	24	any	any	DET
dti-1400	69	25	other	other	ADJ
dti-1400	69	26	publication	publication	NOUN
dti-1400	69	27	,	,	PUNCT
dti-1400	69	28	and	and	CCONJ
dti-1400	69	29	that	that	SCONJ
dti-1400	69	30	they	they	PRON
dti-1400	69	31	have	have	VERB
dti-1400	69	32	permission	permission	NOUN
dti-1400	69	33	from	from	ADP
dti-1400	69	34	the	the	DET
dti-1400	69	35	rights	right	NOUN
dti-1400	69	36	holders	holder	NOUN
dti-1400	69	37	to	to	PART
dti-1400	69	38	reproduce	reproduce	VERB
dti-1400	69	39	any	any	DET
dti-1400	69	40	copyrighted	copyright	VERB
dti-1400	69	41	material	material	NOUN
dti-1400	69	42	.	.	PUNCT
dti-1400	70	1	the	the	DET
dti-1400	70	2	external	external	ADJ
dti-1400	70	3	blind	blind	ADJ
dti-1400	70	4	peer	peer	NOUN
dti-1400	70	5	reviewers	reviewer	NOUN
dti-1400	70	6	report	report	VERB
dti-1400	70	7	no	no	DET
dti-1400	70	8	conflicts	conflict	NOUN
dti-1400	70	9	of	of	ADP
dti-1400	70	10	interest	interest	NOUN
dti-1400	70	11	in	in	ADP
dti-1400	70	12	association	association	NOUN
dti-1400	70	13	with	with	ADP
dti-1400	70	14	this	this	DET
dti-1400	70	15	study	study	NOUN
dti-1400	70	16	.	.	PUNCT
dti-1400	71	1	references	reference	NOUN
dti-1400	71	2	1	1	NUM
dti-1400	71	3	.	.	PUNCT
dti-1400	71	4	ormrod	ormrod	PROPN
dti-1400	71	5	d	d	PROPN
dti-1400	71	6	,	,	PUNCT
dti-1400	71	7	goa	goa	PROPN
dti-1400	71	8	k.	k.	PROPN
dti-1400	72	1	valaciclovir	valaciclovir	PROPN
dti-1400	72	2	:	:	PUNCT
dti-1400	72	3	a	a	DET
dti-1400	72	4	review	review	NOUN
dti-1400	72	5	of	of	ADP
dti-1400	72	6	its	its	PRON
dti-1400	72	7	use	use	NOUN
dti-1400	72	8	in	in	ADP
dti-1400	72	9	the	the	DET
dti-1400	72	10	management	management	NOUN
dti-1400	72	11	of	of	ADP
dti-1400	72	12	herpes	herpe	NOUN
dti-1400	72	13	zoster	zoster	NOUN
dti-1400	72	14	.	.	PUNCT
dti-1400	73	1	drugs	drug	NOUN
dti-1400	73	2	.	.	PUNCT
dti-1400	74	1	2000;59:1317–1340	2000;59:1317–1340	NUM
dti-1400	74	2	.	.	PUNCT
dti-1400	75	1	2	2	NUM
dti-1400	75	2	.	.	X
dti-1400	75	3	perazella	perazella	PROPN
dti-1400	75	4	ma	ma	PROPN
dti-1400	75	5	.	.	PROPN
dti-1400	75	6	crystal	crystal	NOUN
dti-1400	75	7	-	-	PUNCT
dti-1400	75	8	induced	induce	VERB
dti-1400	75	9	acute	acute	ADJ
dti-1400	75	10	renal	renal	ADJ
dti-1400	75	11	failure	failure	NOUN
dti-1400	75	12	.	.	PUNCT
dti-1400	76	1	am	be	AUX
dti-1400	76	2	j	j	PROPN
dti-1400	76	3	med	med	ADJ
dti-1400	76	4	.	.	PUNCT
dti-1400	77	1	1999;106	1999;106	NUM
dti-1400	77	2	:	:	PUNCT
dti-1400	78	1	459–465	459–465	NUM
dti-1400	78	2	.	.	PUNCT
dti-1400	79	1	murakami	murakami	NOUN
dti-1400	79	2	et	et	PROPN
dti-1400	79	3	al	al	PROPN
dti-1400	79	4	5	5	NUM
dti-1400	79	5	3	3	NUM
dti-1400	79	6	.	.	PUNCT
dti-1400	80	1	asahi	asahi	PROPN
dti-1400	80	2	t	t	PROPN
dti-1400	80	3	,	,	PUNCT
dti-1400	80	4	tsutsui	tsutsui	PROPN
dti-1400	80	5	m	m	PROPN
dti-1400	80	6	,	,	PUNCT
dti-1400	80	7	wakasugi	wakasugi	VERB
dti-1400	80	8	m	m	PROPN
dti-1400	80	9	,	,	PUNCT
dti-1400	80	10	et	et	PROPN
dti-1400	80	11	al	al	PROPN
dti-1400	80	12	.	.	PROPN
dti-1400	81	1	valacyclovir	valacyclovir	PROPN
dti-1400	81	2	neurotoxicity	neurotoxicity	NOUN
dti-1400	81	3	:	:	PUNCT
dti-1400	81	4	clinical	clinical	ADJ
dti-1400	81	5	experience	experience	NOUN
dti-1400	81	6	and	and	CCONJ
dti-1400	81	7	review	review	NOUN
dti-1400	81	8	of	of	ADP
dti-1400	81	9	the	the	DET
dti-1400	81	10	literature	literature	NOUN
dti-1400	81	11	.	.	PUNCT
dti-1400	82	1	eur	eur	PROPN
dti-1400	82	2	j	j	PROPN
dti-1400	82	3	neurol	neurol	NOUN
dti-1400	82	4	.	.	PUNCT
dti-1400	83	1	2009;16:457–460	2009;16:457–460	NUM
dti-1400	83	2	.	.	PUNCT
dti-1400	84	1	4	4	X
dti-1400	84	2	.	.	X
dti-1400	84	3	yang	yang	PROPN
dti-1400	84	4	hh	hh	PROPN
dti-1400	84	5	,	,	PUNCT
dti-1400	84	6	hsiao	hsiao	PROPN
dti-1400	84	7	yp	yp	PROPN
dti-1400	84	8	,	,	PUNCT
dti-1400	84	9	shih	shih	PROPN
dti-1400	84	10	hc	hc	PROPN
dti-1400	84	11	,	,	PUNCT
dti-1400	84	12	yang	yang	PROPN
dti-1400	84	13	jh	jh	PROPN
dti-1400	84	14	.	.	PUNCT
dti-1400	85	1	acyclovir	acyclovir	PROPN
dti-1400	85	2	-	-	PUNCT
dti-1400	85	3	induced	induce	VERB
dti-1400	85	4	neuropsychosis	neuropsychosis	NOUN
dti-1400	85	5	successfully	successfully	ADV
dti-1400	85	6	recovered	recover	VERB
dti-1400	85	7	after	after	ADP
dti-1400	85	8	immediate	immediate	ADJ
dti-1400	85	9	hemodialysis	hemodialysis	NOUN
dti-1400	85	10	in	in	ADP
dti-1400	85	11	an	an	DET
dti-1400	85	12	end	end	NOUN
dti-1400	85	13	-	-	PUNCT
dti-1400	85	14	stage	stage	NOUN
dti-1400	85	15	renal	renal	ADJ
dti-1400	85	16	disease	disease	NOUN
dti-1400	85	17	patient	patient	NOUN
dti-1400	85	18	.	.	PUNCT
dti-1400	86	1	int	int	NOUN
dti-1400	86	2	j	j	PROPN
dti-1400	86	3	dermatol	dermatol	NOUN
dti-1400	86	4	.	.	PUNCT
dti-1400	87	1	2007;46:883–884	2007;46:883–884	NUM
dti-1400	87	2	.	.	PUNCT
dti-1400	88	1	5	5	NUM
dti-1400	88	2	.	.	X
dti-1400	88	3	cockcroft	cockcroft	PROPN
dti-1400	88	4	dw	dw	PROPN
dti-1400	88	5	,	,	PUNCT
dti-1400	88	6	gault	gault	PROPN
dti-1400	88	7	mh	mh	PROPN
dti-1400	88	8	.	.	PUNCT
dti-1400	89	1	prediction	prediction	NOUN
dti-1400	89	2	of	of	ADP
dti-1400	89	3	creatinine	creatinine	NOUN
dti-1400	89	4	clearance	clearance	NOUN
dti-1400	89	5	from	from	ADP
dti-1400	89	6	serum	serum	NOUN
dti-1400	89	7	creatinine	creatinine	NOUN
dti-1400	89	8	.	.	PUNCT
dti-1400	90	1	nephron	nephron	NOUN
dti-1400	90	2	.	.	PUNCT
dti-1400	91	1	1976;16(1):31–41	1976;16(1):31–41	X
dti-1400	91	2	.	.	PUNCT
dti-1400	92	1	6	6	NUM
dti-1400	92	2	.	.	X
dti-1400	92	3	matsuo	matsuo	PROPN
dti-1400	92	4	s	s	PROPN
dti-1400	92	5	,	,	PUNCT
dti-1400	92	6	imai	imai	PROPN
dti-1400	92	7	e	e	PROPN
dti-1400	92	8	,	,	PUNCT
dti-1400	92	9	horio	horio	PROPN
dti-1400	92	10	m	m	PROPN
dti-1400	92	11	,	,	PUNCT
dti-1400	92	12	et	et	PROPN
dti-1400	92	13	al	al	PROPN
dti-1400	92	14	.	.	PROPN
dti-1400	92	15	revised	revise	VERB
dti-1400	92	16	equations	equation	NOUN
dti-1400	92	17	for	for	ADP
dti-1400	92	18	estimated	estimate	VERB
dti-1400	92	19	gfr	gfr	NOUN
dti-1400	92	20	from	from	ADP
dti-1400	92	21	serum	serum	NOUN
dti-1400	92	22	creatinine	creatinine	NOUN
dti-1400	92	23	in	in	ADP
dti-1400	92	24	japan	japan	PROPN
dti-1400	92	25	.	.	PUNCT
dti-1400	93	1	am	be	AUX
dti-1400	93	2	j	j	PROPN
dti-1400	93	3	kidney	kidney	PROPN
dti-1400	93	4	dis	dis	PROPN
dti-1400	93	5	.	.	PUNCT
dti-1400	94	1	2009;53(6):982–992	2009;53(6):982–992	NUM
dti-1400	94	2	.	.	NOUN
dti-1400	94	3	7	7	NUM
dti-1400	94	4	.	.	X
dti-1400	94	5	verbalis	verbalis	PROPN
dti-1400	94	6	jg	jg	PROPN
dti-1400	94	7	,	,	PUNCT
dti-1400	94	8	goldsmith	goldsmith	PROPN
dti-1400	94	9	sr	sr	PROPN
dti-1400	94	10	,	,	PUNCT
dti-1400	94	11	greenberg	greenberg	PROPN
dti-1400	94	12	a	a	PROPN
dti-1400	94	13	,	,	PUNCT
dti-1400	94	14	schrier	schrier	NOUN
dti-1400	94	15	rw	rw	NOUN
dti-1400	94	16	,	,	PUNCT
dti-1400	94	17	sterns	sterns	PROPN
dti-1400	94	18	rh	rh	PROPN
dti-1400	94	19	.	.	PUNCT
dti-1400	95	1	hyponatremia	hyponatremia	PROPN
dti-1400	95	2	treatment	treatment	NOUN
dti-1400	95	3	guidelines	guideline	NOUN
dti-1400	95	4	2007	2007	NUM
dti-1400	95	5	:	:	PUNCT
dti-1400	95	6	expert	expert	NOUN
dti-1400	95	7	panel	panel	NOUN
dti-1400	95	8	recommendations	recommendation	NOUN
dti-1400	95	9	.	.	PUNCT
dti-1400	96	1	am	be	AUX
dti-1400	96	2	j	j	PROPN
dti-1400	96	3	med	med	PROPN
dti-1400	96	4	.	.	PUNCT
dti-1400	96	5	2007	2007	NUM
dti-1400	96	6	;	;	PUNCT
dti-1400	96	7	120(11	120(11	NUM
dti-1400	96	8	suppl	suppl	PROPN
dti-1400	96	9	1):s1–21	1):s1–21	PROPN
dti-1400	96	10	.	.	PROPN
dti-1400	96	11	8	8	NUM
dti-1400	96	12	.	.	PUNCT
dti-1400	96	13	krieble	krieble	ADJ
dti-1400	96	14	bf	bf	PROPN
dti-1400	96	15	,	,	PUNCT
dti-1400	96	16	rudy	rudy	PROPN
dti-1400	96	17	dw	dw	PROPN
dti-1400	96	18	,	,	PUNCT
dti-1400	96	19	glick	glick	PROPN
dti-1400	96	20	mr	mr	PROPN
dti-1400	96	21	,	,	PUNCT
dti-1400	96	22	clayman	clayman	PROPN
dti-1400	96	23	md	md	PROPN
dti-1400	96	24	.	.	PUNCT
dti-1400	96	25	case	case	NOUN
dti-1400	96	26	report	report	NOUN
dti-1400	96	27	:	:	PUNCT
dti-1400	96	28	acyclovir	acyclovir	PROPN
dti-1400	96	29	neurotoxicity	neurotoxicity	NOUN
dti-1400	96	30	and	and	CCONJ
dti-1400	96	31	nephrotoxicity	nephrotoxicity	NOUN
dti-1400	96	32	—	—	PUNCT
dti-1400	96	33	the	the	DET
dti-1400	96	34	role	role	NOUN
dti-1400	96	35	for	for	ADP
dti-1400	96	36	hemodialysis	hemodialysis	NOUN
dti-1400	96	37	.	.	PUNCT
dti-1400	97	1	am	be	AUX
dti-1400	97	2	j	j	PROPN
dti-1400	97	3	med	med	PROPN
dti-1400	97	4	sci	sci	PROPN
dti-1400	97	5	.	.	PROPN
dti-1400	98	1	1993;305:36–39	1993;305:36–39	NUM
dti-1400	98	2	.	.	PROPN
dti-1400	98	3	9	9	NUM
dti-1400	98	4	.	.	X
dti-1400	98	5	sodhi	sodhi	PROPN
dti-1400	98	6	pk	pk	PROPN
dti-1400	98	7	,	,	PUNCT
dti-1400	98	8	ratan	ratan	PROPN
dti-1400	98	9	sk	sk	PROPN
dti-1400	98	10	.	.	PUNCT
dti-1400	99	1	a	a	DET
dti-1400	99	2	case	case	NOUN
dti-1400	99	3	of	of	ADP
dti-1400	99	4	chronic	chronic	ADJ
dti-1400	99	5	renal	renal	ADJ
dti-1400	99	6	dysfunction	dysfunction	NOUN
dti-1400	99	7	following	follow	VERB
dti-1400	99	8	treatment	treatment	NOUN
dti-1400	99	9	with	with	ADP
dti-1400	99	10	oral	oral	ADJ
dti-1400	99	11	acyclovir	acyclovir	PROPN
dti-1400	99	12	.	.	PUNCT
dti-1400	100	1	scand	scand	PROPN
dti-1400	100	2	j	j	PROPN
dti-1400	100	3	infect	infect	PROPN
dti-1400	100	4	dis	dis	PROPN
dti-1400	100	5	.	.	PUNCT
dti-1400	101	1	2003	2003	NUM
dti-1400	101	2	;	;	PUNCT
dti-1400	101	3	35(10):770–772	35(10):770–772	NUM
dti-1400	101	4	.	.	NOUN
dti-1400	101	5	10	10	NUM
dti-1400	101	6	.	.	PUNCT
dti-1400	102	1	carlon	carlon	PROPN
dti-1400	102	2	r	r	PROPN
dti-1400	102	3	,	,	PUNCT
dti-1400	102	4	possamai	possamai	NOUN
dti-1400	102	5	c	c	NOUN
dti-1400	102	6	,	,	PUNCT
dti-1400	102	7	corbanese	corbanese	PROPN
dti-1400	102	8	u.	u.	PROPN
dti-1400	102	9	acute	acute	PROPN
dti-1400	102	10	renal	renal	ADJ
dti-1400	102	11	failure	failure	NOUN
dti-1400	102	12	and	and	CCONJ
dti-1400	102	13	severe	severe	ADJ
dti-1400	102	14	neurotoxicity	neurotoxicity	NOUN
dti-1400	102	15	following	follow	VERB
dti-1400	102	16	valacyclovir	valacyclovir	PROPN
dti-1400	102	17	.	.	PUNCT
dti-1400	103	1	intensive	intensive	ADJ
dti-1400	103	2	care	care	NOUN
dti-1400	103	3	med	me	VERB
dti-1400	103	4	.	.	PUNCT
dti-1400	103	5	2005	2005	NUM
dti-1400	103	6	;	;	PUNCT
dti-1400	103	7	31(11):1593	31(11):1593	NUM
dti-1400	103	8	.	.	NOUN
dti-1400	103	9	11	11	NUM
dti-1400	103	10	.	.	PUNCT
dti-1400	104	1	sugimoto	sugimoto	PROPN
dti-1400	104	2	t	t	PROPN
dti-1400	104	3	,	,	PUNCT
dti-1400	104	4	yasuda	yasuda	PROPN
dti-1400	104	5	m	m	PROPN
dti-1400	104	6	,	,	PUNCT
dti-1400	104	7	sakaguchi	sakaguchi	PROPN
dti-1400	104	8	m	m	PROPN
dti-1400	104	9	,	,	PUNCT
dti-1400	104	10	et	et	PROPN
dti-1400	104	11	al	al	PROPN
dti-1400	104	12	.	.	PROPN
dti-1400	104	13	oliguric	oliguric	ADJ
dti-1400	104	14	acute	acute	ADJ
dti-1400	104	15	renal	renal	ADJ
dti-1400	104	16	failure	failure	NOUN
dti-1400	104	17	following	follow	VERB
dti-1400	104	18	oral	oral	ADJ
dti-1400	104	19	valacyclovir	valacyclovir	PROPN
dti-1400	104	20	therapy	therapy	NOUN
dti-1400	104	21	.	.	PUNCT
dti-1400	105	1	qjm	qjm	INTJ
dti-1400	105	2	.	.	PUNCT
dti-1400	105	3	2008	2008	NUM
dti-1400	105	4	;	;	PUNCT
dti-1400	105	5	101(2):164–166	101(2):164–166	NUM
dti-1400	105	6	.	.	NOUN
dti-1400	105	7	12	12	NUM
dti-1400	105	8	.	.	PUNCT
dti-1400	105	9	leikin	leikin	PROPN
dti-1400	105	10	jb	jb	PROPN
dti-1400	105	11	,	,	PUNCT
dti-1400	105	12	shicker	shicker	PROPN
dti-1400	105	13	l	l	NOUN
dti-1400	105	14	,	,	PUNCT
dti-1400	105	15	orlowski	orlowski	PROPN
dti-1400	105	16	j	j	PROPN
dti-1400	105	17	,	,	PUNCT
dti-1400	105	18	blair	blair	PROPN
dti-1400	105	19	at	at	ADP
dti-1400	105	20	,	,	PUNCT
dti-1400	106	1	mcallister	mcallister	PROPN
dti-1400	106	2	k.	k.	PROPN
dti-1400	106	3	hemodialysis	hemodialysis	PROPN
dti-1400	106	4	removal	removal	NOUN
dti-1400	106	5	of	of	ADP
dti-1400	106	6	acyclovir	acyclovir	PROPN
dti-1400	106	7	.	.	PUNCT
dti-1400	107	1	vet	vet	NOUN
dti-1400	107	2	hum	hum	NOUN
dti-1400	107	3	toxicol	toxicol	PROPN
dti-1400	107	4	.	.	PUNCT
dti-1400	108	1	1995;37:233–234	1995;37:233–234	X
dti-1400	108	2	.	.	PUNCT
dti-1400	109	1	13	13	NUM
dti-1400	109	2	.	.	PUNCT
dti-1400	110	1	hsu	hsu	PROPN
dti-1400	110	2	cc	cc	PROPN
dti-1400	110	3	,	,	PUNCT
dti-1400	110	4	lai	lai	PROPN
dti-1400	110	5	ti	ti	PROPN
dti-1400	110	6	,	,	PUNCT
dti-1400	110	7	lien	lien	PROPN
dti-1400	110	8	wc	wc	PROPN
dti-1400	110	9	,	,	PUNCT
dti-1400	110	10	chen	chen	PROPN
dti-1400	110	11	wj	wj	PROPN
dti-1400	110	12	,	,	PUNCT
dti-1400	110	13	fang	fang	PROPN
dti-1400	110	14	cc	cc	PROPN
dti-1400	110	15	.	.	PROPN
dti-1400	110	16	emergent	emergent	ADJ
dti-1400	110	17	hemodialysis	hemodialysis	NOUN
dti-1400	110	18	for	for	ADP
dti-1400	110	19	acyclovir	acyclovir	PROPN
dti-1400	110	20	toxicity	toxicity	PROPN
dti-1400	110	21	.	.	PUNCT
dti-1400	111	1	am	be	AUX
dti-1400	111	2	j	j	PROPN
dti-1400	111	3	emerg	emerg	PROPN
dti-1400	111	4	med	med	PROPN
dti-1400	111	5	.	.	PUNCT
dti-1400	112	1	2005;23:899–900	2005;23:899–900	ADJ
dti-1400	112	2	.	.	PUNCT
dti-1400	113	1	14	14	NUM
dti-1400	113	2	.	.	PUNCT
dti-1400	114	1	kambhampati	kambhampati	PROPN
dti-1400	114	2	g	g	PROPN
dti-1400	114	3	,	,	PUNCT
dti-1400	114	4	pakkivenkata	pakkivenkata	NOUN
dti-1400	114	5	u	u	NOUN
dti-1400	114	6	,	,	PUNCT
dti-1400	114	7	kazory	kazory	ADJ
dti-1400	114	8	a.	a.	NOUN
dti-1400	114	9	valacyclovir	valacyclovir	PROPN
dti-1400	114	10	neurotoxicity	neurotoxicity	PROPN
dti-1400	114	11	can	can	AUX
dti-1400	114	12	be	be	AUX
dti-1400	114	13	effectively	effectively	ADV
dti-1400	114	14	managed	manage	VERB
dti-1400	114	15	by	by	ADP
dti-1400	114	16	hemodialysis	hemodialysis	NOUN
dti-1400	114	17	.	.	PUNCT
dti-1400	115	1	eur	eur	PROPN
dti-1400	115	2	j	j	PROPN
dti-1400	115	3	neurol	neurol	PROPN
dti-1400	115	4	.	.	PUNCT
dti-1400	116	1	2011;18	2011;18	NUM
dti-1400	116	2	:	:	PUNCT
dti-1400	116	3	e33	e33	PROPN
dti-1400	116	4	.	.	PUNCT
dti-1400	117	1	15	15	NUM
dti-1400	117	2	.	.	PUNCT
dti-1400	117	3	bleyzac	bleyzac	PROPN
dti-1400	117	4	n	n	CCONJ
dti-1400	117	5	,	,	PUNCT
dti-1400	117	6	barou	barou	VERB
dti-1400	117	7	p	p	NOUN
dti-1400	117	8	,	,	PUNCT
dti-1400	117	9	massenavette	massenavette	PROPN
dti-1400	117	10	b	b	PROPN
dti-1400	117	11	,	,	PUNCT
dti-1400	117	12	et	et	PROPN
dti-1400	117	13	al	al	PROPN
dti-1400	117	14	.	.	PROPN
dti-1400	117	15	assessment	assessment	NOUN
dti-1400	117	16	of	of	ADP
dti-1400	117	17	acyclovir	acyclovir	PROPN
dti-1400	117	18	intraindividual	intraindividual	ADJ
dti-1400	117	19	pharmacokinetic	pharmacokinetic	ADJ
dti-1400	117	20	variability	variability	NOUN
dti-1400	117	21	during	during	ADP
dti-1400	117	22	continuous	continuous	ADJ
dti-1400	117	23	hemofiltration	hemofiltration	NOUN
dti-1400	117	24	,	,	PUNCT
dti-1400	117	25	continuous	continuous	ADJ
dti-1400	117	26	hemodiafiltration	hemodiafiltration	NOUN
dti-1400	117	27	,	,	PUNCT
dti-1400	117	28	and	and	CCONJ
dti-1400	117	29	continuous	continuous	ADJ
dti-1400	117	30	hemodialysis	hemodialysis	NOUN
dti-1400	117	31	.	.	PUNCT
dti-1400	118	1	ther	ther	PROPN
dti-1400	118	2	drug	drug	PROPN
dti-1400	118	3	monit	monit	PROPN
dti-1400	118	4	.	.	PUNCT
dti-1400	119	1	1999;21	1999;21	NUM
dti-1400	119	2	:	:	PUNCT
dti-1400	120	1	520–525	520–525	NUM
dti-1400	120	2	.	.	PUNCT
dti-1400	121	1	16	16	NUM
dti-1400	121	2	.	.	PUNCT
dti-1400	122	1	yessayan	yessayan	PROPN
dti-1400	122	2	l	l	PROPN
dti-1400	122	3	,	,	PUNCT
dti-1400	122	4	yee	yee	PROPN
dti-1400	122	5	j	j	PROPN
dti-1400	122	6	,	,	PUNCT
dti-1400	122	7	frinak	frinak	PROPN
dti-1400	122	8	s	s	PROPN
dti-1400	122	9	,	,	PUNCT
dti-1400	122	10	szamosfalvi	szamosfalvi	PROPN
dti-1400	122	11	b.	b.	PROPN
dti-1400	122	12	treatment	treatment	NOUN
dti-1400	122	13	of	of	ADP
dti-1400	122	14	severe	severe	ADJ
dti-1400	122	15	hyponatremia	hyponatremia	NOUN
dti-1400	122	16	in	in	ADP
dti-1400	122	17	patients	patient	NOUN
dti-1400	122	18	with	with	ADP
dti-1400	122	19	kidney	kidney	NOUN
dti-1400	122	20	failure	failure	NOUN
dti-1400	122	21	:	:	PUNCT
dti-1400	122	22	role	role	NOUN
dti-1400	122	23	of	of	ADP
dti-1400	122	24	continuous	continuous	ADJ
dti-1400	122	25	venovenous	venovenous	ADJ
dti-1400	122	26	hemofiltration	hemofiltration	NOUN
dti-1400	122	27	with	with	ADP
dti-1400	122	28	low	low	ADJ
dti-1400	122	29	-	-	PUNCT
dti-1400	122	30	sodium	sodium	NOUN
dti-1400	122	31	replacement	replacement	NOUN
dti-1400	122	32	fluid	fluid	NOUN
dti-1400	122	33	.	.	PUNCT
dti-1400	122	34	am	be	AUX
dti-1400	122	35	j	j	PROPN
dti-1400	122	36	kidney	kidney	PROPN
dti-1400	122	37	dis	dis	PROPN
dti-1400	122	38	.	.	PUNCT
dti-1400	123	1	2014;64:305–310	2014;64:305–310	PROPN
dti-1400	123	2	.	.	PUNCT
dti-1400	124	1	17	17	NUM
dti-1400	124	2	.	.	PUNCT
dti-1400	124	3	di	di	PROPN
dti-1400	124	4	filippo	filippo	PROPN
dti-1400	124	5	s	s	PROPN
dti-1400	124	6	,	,	PUNCT
dti-1400	124	7	manzoni	manzoni	PROPN
dti-1400	124	8	c	c	PROPN
dti-1400	124	9	,	,	PUNCT
dti-1400	124	10	andrulli	andrulli	PROPN
dti-1400	124	11	s	s	PROPN
dti-1400	124	12	,	,	PUNCT
dti-1400	124	13	tentori	tentori	NOUN
dti-1400	124	14	f	f	NOUN
dti-1400	124	15	,	,	PUNCT
dti-1400	124	16	locatelli	locatelli	PROPN
dti-1400	124	17	f.	f.	PROPN
dti-1400	124	18	sodium	sodium	PROPN
dti-1400	124	19	removal	removal	NOUN
dti-1400	124	20	during	during	ADP
dti-1400	124	21	pre	pre	ADJ
dti-1400	124	22	-	-	ADJ
dti-1400	124	23	dilution	dilution	ADJ
dti-1400	124	24	haemofiltration	haemofiltration	NOUN
dti-1400	124	25	.	.	PUNCT
dti-1400	125	1	nephrol	nephrol	PROPN
dti-1400	125	2	dial	dial	NOUN
dti-1400	125	3	transplant	transplant	NOUN
dti-1400	125	4	.	.	PUNCT
dti-1400	126	1	2003;18	2003;18	X
dti-1400	126	2	:	:	PUNCT
dti-1400	126	3	vii31	vii31	NOUN
dti-1400	126	4	–	–	PUNCT
dti-1400	126	5	vii36	vii36	NOUN
dti-1400	126	6	.	.	PUNCT
dti-1400	127	1	18	18	NUM
dti-1400	127	2	.	.	X
dti-1400	127	3	meng	meng	PROPN
dti-1400	127	4	jb	jb	PROPN
dti-1400	127	5	,	,	PUNCT
dti-1400	127	6	zheng	zheng	PROPN
dti-1400	127	7	x	x	PROPN
dti-1400	127	8	,	,	PUNCT
dti-1400	127	9	zhang	zhang	PROPN
dti-1400	127	10	g	g	PROPN
dti-1400	127	11	,	,	PUNCT
dti-1400	127	12	fang	fang	PROPN
dti-1400	127	13	q.	q.	PROPN
dti-1400	127	14	oral	oral	PROPN
dti-1400	127	15	acyclovir	acyclovir	PROPN
dti-1400	127	16	induced	induce	VERB
dti-1400	127	17	acute	acute	ADJ
dti-1400	127	18	renal	renal	ADJ
dti-1400	127	19	failure	failure	NOUN
dti-1400	127	20	.	.	PUNCT
dti-1400	128	1	world	world	PROPN
dti-1400	128	2	j	j	PROPN
dti-1400	128	3	emerg	emerg	PROPN
dti-1400	128	4	med	med	PROPN
dti-1400	128	5	.	.	PUNCT
dti-1400	129	1	2011;2:310–313	2011;2:310–313	NUM
dti-1400	129	2	.	.	NOUN
dti-1400	130	1	19	19	NUM
dti-1400	130	2	.	.	PUNCT
dti-1400	131	1	winchester	winchester	PROPN
dti-1400	131	2	jf	jf	PROPN
dti-1400	131	3	,	,	PUNCT
dti-1400	131	4	harboud	harboud	PROPN
dti-1400	131	5	nb	nb	PROPN
dti-1400	131	6	,	,	PUNCT
dti-1400	131	7	charen	charen	PROPN
dti-1400	131	8	e	e	PROPN
dti-1400	131	9	,	,	PUNCT
dti-1400	131	10	ghannoum	ghannoum	NOUN
dti-1400	131	11	m.	m.	NOUN
dti-1400	131	12	use	use	NOUN
dti-1400	131	13	of	of	ADP
dti-1400	131	14	dialysis	dialysis	NOUN
dti-1400	131	15	and	and	CCONJ
dti-1400	131	16	hemoperfusion	hemoperfusion	NOUN
dti-1400	131	17	in	in	ADP
dti-1400	131	18	the	the	DET
dti-1400	131	19	treatment	treatment	NOUN
dti-1400	131	20	of	of	ADP
dti-1400	131	21	poisoning	poisoning	NOUN
dti-1400	131	22	.	.	PUNCT
dti-1400	132	1	in	in	ADP
dti-1400	132	2	:	:	PUNCT
dti-1400	132	3	daugirdas	daugirdas	PROPN
dti-1400	132	4	jt	jt	PROPN
dti-1400	132	5	,	,	PUNCT
dti-1400	132	6	blake	blake	PROPN
dti-1400	132	7	pg	pg	PROPN
dti-1400	132	8	,	,	PUNCT
dti-1400	132	9	ing	ing	ADJ
dti-1400	132	10	ts	ts	NOUN
dti-1400	132	11	,	,	PUNCT
dti-1400	132	12	eds	eds	PROPN
dti-1400	132	13	.	.	PUNCT
dti-1400	132	14	handbook	handbook	NOUN
dti-1400	132	15	of	of	ADP
dti-1400	132	16	dialysis	dialysis	NOUN
dti-1400	132	17	,	,	PUNCT
dti-1400	132	18	5th	5th	ADJ
dti-1400	132	19	ed	ed	NOUN
dti-1400	132	20	.	.	PUNCT
dti-1400	132	21	philadelphia	philadelphia	PROPN
dti-1400	132	22	,	,	PUNCT
dti-1400	132	23	pa	pa	PROPN
dti-1400	132	24	:	:	PUNCT
dti-1400	132	25	wolters	wolters	PROPN
dti-1400	132	26	kluwer	kluwer	PROPN
dti-1400	132	27	;	;	PUNCT
dti-1400	132	28	2015:368–390	2015:368–390	X
dti-1400	132	29	.	.	NOUN
dti-1400	132	30	20	20	NUM
dti-1400	132	31	.	.	PUNCT
dti-1400	133	1	oo	oo	PROPN
dti-1400	133	2	tn	tn	PROPN
dti-1400	133	3	,	,	PUNCT
dti-1400	133	4	smith	smith	PROPN
dti-1400	133	5	cl	cl	PROPN
dti-1400	133	6	,	,	PUNCT
dti-1400	133	7	swan	swan	NOUN
dti-1400	133	8	sk	sk	VERB
dti-1400	133	9	.	.	PROPN
dti-1400	133	10	does	do	AUX
dti-1400	133	11	uremia	uremia	NOUN
dti-1400	133	12	protect	protect	VERB
dti-1400	133	13	against	against	ADP
dti-1400	133	14	the	the	DET
dti-1400	133	15	demyelination	demyelination	NOUN
dti-1400	133	16	associated	associate	VERB
dti-1400	133	17	with	with	ADP
dti-1400	133	18	correction	correction	NOUN
dti-1400	133	19	of	of	ADP
dti-1400	133	20	hyponatremia	hyponatremia	NOUN
dti-1400	133	21	during	during	ADP
dti-1400	133	22	hemodialysis	hemodialysis	NOUN
dti-1400	133	23	?	?	PUNCT
dti-1400	134	1	a	a	DET
dti-1400	134	2	case	case	NOUN
dti-1400	134	3	report	report	NOUN
dti-1400	134	4	and	and	CCONJ
dti-1400	134	5	literature	literature	PROPN
dti-1400	134	6	review	review	PROPN
dti-1400	134	7	.	.	PUNCT
dti-1400	135	1	semin	semin	PROPN
dti-1400	135	2	dial	dial	PROPN
dti-1400	135	3	.	.	PUNCT
dti-1400	136	1	2003;16:68–71	2003;16:68–71	NUM
dti-1400	136	2	.	.	PUNCT
dti-1400	137	1	21	21	NUM
dti-1400	137	2	.	.	PUNCT
dti-1400	137	3	sirota	sirota	PROPN
dti-1400	137	4	jc	jc	PROPN
dti-1400	137	5	,	,	PUNCT
dti-1400	137	6	berl	berl	PROPN
dti-1400	137	7	t.	t.	PROPN
dti-1400	137	8	is	be	AUX
dti-1400	137	9	osmotic	osmotic	ADJ
dti-1400	137	10	demyelination	demyelination	NOUN
dti-1400	137	11	a	a	DET
dti-1400	137	12	concern	concern	NOUN
dti-1400	137	13	dialyzing	dialyze	VERB
dti-1400	137	14	hyponatremic	hyponatremic	ADJ
dti-1400	137	15	patients	patient	NOUN
dti-1400	137	16	?	?	PUNCT
dti-1400	138	1	semin	semin	PROPN
dti-1400	138	2	dial	dial	PROPN
dti-1400	138	3	.	.	PUNCT
dti-1400	139	1	2011;24:407–409	2011;24:407–409	X
dti-1400	139	2	.	.	PUNCT
dti-1400	140	1	22	22	NUM
dti-1400	140	2	.	.	PUNCT
dti-1400	141	1	dhrolia	dhrolia	PROPN
dti-1400	141	2	mf	mf	PROPN
dti-1400	141	3	,	,	PUNCT
dti-1400	141	4	akhtar	akhtar	PROPN
dti-1400	141	5	sf	sf	PROPN
dti-1400	141	6	,	,	PUNCT
dti-1400	141	7	ahmed	ahmed	PROPN
dti-1400	141	8	e	e	PROPN
dti-1400	141	9	,	,	PUNCT
dti-1400	141	10	naqvi	naqvi	PROPN
dti-1400	141	11	a	a	PRON
dti-1400	141	12	,	,	PUNCT
dti-1400	141	13	rizvi	rizvi	ADJ
dti-1400	141	14	a.	a.	NOUN
dti-1400	141	15	azotemia	azotemia	PROPN
dti-1400	141	16	protects	protect	VERB
dti-1400	141	17	the	the	DET
dti-1400	141	18	brain	brain	NOUN
dti-1400	141	19	from	from	ADP
dti-1400	141	20	osmotic	osmotic	ADJ
dti-1400	141	21	demyelination	demyelination	NOUN
dti-1400	141	22	on	on	ADP
dti-1400	141	23	rapid	rapid	ADJ
dti-1400	141	24	correction	correction	NOUN
dti-1400	141	25	of	of	ADP
dti-1400	141	26	hyponatremia	hyponatremia	PROPN
dti-1400	141	27	.	.	PUNCT
dti-1400	142	1	saudi	saudi	PROPN
dti-1400	142	2	j	j	PROPN
dti-1400	142	3	kidney	kidney	PROPN
dti-1400	142	4	dis	dis	PROPN
dti-1400	142	5	transpl	transpl	NOUN
dti-1400	142	6	.	.	PUNCT
dti-1400	143	1	2014;25:558–566	2014;25:558–566	INTJ
dti-1400	143	2	.	.	PUNCT
dti-1400	144	1	23	23	NUM
dti-1400	144	2	.	.	PUNCT
dti-1400	145	1	huang	huang	PROPN
dti-1400	145	2	wy	wy	PROPN
dti-1400	145	3	,	,	PUNCT
dti-1400	145	4	weng	weng	PROPN
dti-1400	145	5	wc	wc	PROPN
dti-1400	145	6	,	,	PUNCT
dti-1400	145	7	peng	peng	PROPN
dti-1400	145	8	ti	ti	PROPN
dti-1400	145	9	,	,	PUNCT
dti-1400	145	10	ro	ro	PROPN
dti-1400	145	11	ls	ls	PROPN
dti-1400	145	12	,	,	PUNCT
dti-1400	145	13	yang	yang	PROPN
dti-1400	145	14	cw	cw	PROPN
dti-1400	145	15	,	,	PUNCT
dti-1400	145	16	chen	chen	PROPN
dti-1400	145	17	kh	kh	PROPN
dti-1400	145	18	.	.	PROPN
dti-1400	145	19	central	central	PROPN
dti-1400	145	20	pontine	pontine	NOUN
dti-1400	145	21	and	and	CCONJ
dti-1400	145	22	extrapontine	extrapontine	VERB
dti-1400	145	23	myelinolysis	myelinolysis	NOUN
dti-1400	145	24	after	after	ADP
dti-1400	145	25	rapid	rapid	ADJ
dti-1400	145	26	correction	correction	NOUN
dti-1400	145	27	of	of	ADP
dti-1400	145	28	hyponatremia	hyponatremia	NOUN
dti-1400	145	29	by	by	ADP
dti-1400	145	30	hemodialysis	hemodialysis	NOUN
dti-1400	145	31	in	in	ADP
dti-1400	145	32	a	a	DET
dti-1400	145	33	uremic	uremic	ADJ
dti-1400	145	34	patient	patient	NOUN
dti-1400	145	35	.	.	PUNCT
dti-1400	146	1	ren	ren	PROPN
dti-1400	146	2	fail	fail	VERB
dti-1400	146	3	.	.	PUNCT
dti-1400	147	1	2007;29:635–638	2007;29:635–638	X
dti-1400	147	2	.	.	PUNCT
dti-1400	148	1	24	24	NUM
dti-1400	148	2	.	.	PUNCT
dti-1400	149	1	ferreira	ferreira	PROPN
dti-1400	149	2	m	m	PROPN
dti-1400	149	3	,	,	PUNCT
dti-1400	149	4	vega	vega	PROPN
dti-1400	149	5	c	c	PROPN
dti-1400	149	6	,	,	PUNCT
dti-1400	149	7	rivas	rivas	PROPN
dti-1400	149	8	b	b	PROPN
dti-1400	149	9	,	,	PUNCT
dti-1400	149	10	selgas	selgas	PROPN
dti-1400	149	11	r.	r.	PROPN
dti-1400	149	12	acute	acute	PROPN
dti-1400	149	13	renal	renal	ADJ
dti-1400	149	14	failure	failure	NOUN
dti-1400	149	15	and	and	CCONJ
dti-1400	149	16	severe	severe	ADJ
dti-1400	149	17	neurotoxicity	neurotoxicity	NOUN
dti-1400	149	18	after	after	ADP
dti-1400	149	19	unintentional	unintentional	ADJ
dti-1400	149	20	overdose	overdose	NOUN
dti-1400	149	21	of	of	ADP
dti-1400	149	22	valacyclovir	valacyclovir	NOUN
dti-1400	149	23	in	in	ADP
dti-1400	149	24	a	a	DET
dti-1400	149	25	geriatric	geriatric	ADJ
dti-1400	149	26	population	population	NOUN
dti-1400	149	27	:	:	PUNCT
dti-1400	149	28	a	a	DET
dti-1400	149	29	case	case	NOUN
dti-1400	149	30	report	report	NOUN
dti-1400	149	31	.	.	PUNCT
dti-1400	150	1	nefrología	nefrología	ADJ
dti-1400	150	2	.	.	PUNCT
dti-1400	151	1	2018;38:323–325	2018;38:323–325	NUM
dti-1400	151	2	.	.	PUNCT
dti-1400	152	1	25	25	NUM
dti-1400	152	2	.	.	PUNCT
dti-1400	152	3	cortejoso	cortejoso	PROPN
dti-1400	152	4	l	l	PROPN
dti-1400	152	5	,	,	PUNCT
dti-1400	152	6	gómez	gómez	NOUN
dti-1400	152	7	-	-	PUNCT
dti-1400	152	8	antúnez	antúnez	PROPN
dti-1400	152	9	m	m	NOUN
dti-1400	152	10	,	,	PUNCT
dti-1400	152	11	muiño	muiño	ADJ
dti-1400	152	12	-	-	PUNCT
dti-1400	152	13	míguez	míguez	NOUN
dti-1400	152	14	a	a	PRON
dti-1400	152	15	,	,	PUNCT
dti-1400	152	16	durán	durán	NOUN
dti-1400	152	17	-	-	PUNCT
dti-1400	152	18	garcía	garcía	VERB
dti-1400	152	19	me	i	PRON
dti-1400	152	20	,	,	PUNCT
dti-1400	152	21	sanjurjo	sanjurjo	NOUN
dti-1400	152	22	-	-	PUNCT
dti-1400	152	23	sáez	sáez	PROPN
dti-1400	152	24	m.	m.	NOUN
dti-1400	152	25	acyclovir	acyclovir	PROPN
dti-1400	152	26	and	and	CCONJ
dti-1400	152	27	hyponatremia	hyponatremia	PROPN
dti-1400	152	28	:	:	PUNCT
dti-1400	152	29	a	a	DET
dti-1400	152	30	case	case	NOUN
dti-1400	152	31	report	report	NOUN
dti-1400	152	32	.	.	PUNCT
dti-1400	153	1	am	be	AUX
dti-1400	153	2	j	j	PROPN
dti-1400	153	3	ther	ther	ADV
dti-1400	153	4	.	.	PUNCT
dti-1400	154	1	2014;21	2014;21	NOUN
dti-1400	154	2	:	:	PUNCT
dti-1400	154	3	e151	e151	PROPN
dti-1400	154	4	–	–	PUNCT
dti-1400	154	5	e153	e153	PROPN
dti-1400	154	6	.	.	PROPN
dti-1400	154	7	26	26	NUM
dti-1400	154	8	.	.	PUNCT
dti-1400	155	1	sterns	sterns	PROPN
dti-1400	155	2	rh	rh	PROPN
dti-1400	155	3	.	.	PUNCT
dti-1400	156	1	disorders	disorder	NOUN
dti-1400	156	2	of	of	ADP
dti-1400	156	3	plasma	plasma	NOUN
dti-1400	156	4	sodium	sodium	NOUN
dti-1400	156	5	—	—	PUNCT
dti-1400	156	6	causes	cause	NOUN
dti-1400	156	7	,	,	PUNCT
dti-1400	156	8	consequences	consequence	NOUN
dti-1400	156	9	,	,	PUNCT
dti-1400	156	10	and	and	CCONJ
dti-1400	156	11	correction	correction	NOUN
dti-1400	156	12	.	.	PUNCT
dti-1400	157	1	n	n	PROPN
dti-1400	157	2	engl	engl	PROPN
dti-1400	157	3	j	j	PROPN
dti-1400	157	4	med	med	PROPN
dti-1400	157	5	.	.	PUNCT
dti-1400	158	1	2015;372:55–65	2015;372:55–65	NUM
dti-1400	158	2	.	.	PROPN
dti-1400	159	1	27	27	NUM
dti-1400	159	2	.	.	PUNCT
dti-1400	160	1	dos	do	NOUN
dti-1400	160	2	santos	santos	PROPN
dti-1400	160	3	mde	mde	PROPN
dti-1400	160	4	f	f	AUX
dti-1400	160	5	,	,	PUNCT
dti-1400	160	6	dos	do	VERB
dti-1400	160	7	santos	santo	NOUN
dti-1400	160	8	of	of	ADP
dti-1400	160	9	,	,	PUNCT
dti-1400	160	10	boim	boim	PROPN
dti-1400	160	11	ma	ma	PROPN
dti-1400	160	12	,	,	PUNCT
dti-1400	160	13	et	et	PROPN
dti-1400	160	14	al	al	PROPN
dti-1400	160	15	.	.	PROPN
dti-1400	160	16	nephrotoxicity	nephrotoxicity	PROPN
dti-1400	160	17	of	of	ADP
dti-1400	160	18	acyclovir	acyclovir	PROPN
dti-1400	160	19	and	and	CCONJ
dti-1400	160	20	ganciclovir	ganciclovir	VERB
dti-1400	160	21	in	in	ADP
dti-1400	160	22	rats	rat	NOUN
dti-1400	160	23	:	:	PUNCT
dti-1400	160	24	evaluation	evaluation	NOUN
dti-1400	160	25	of	of	ADP
dti-1400	160	26	glomerular	glomerular	ADJ
dti-1400	160	27	hemodynamics	hemodynamic	NOUN
dti-1400	160	28	.	.	PUNCT
dti-1400	161	1	j	j	PROPN
dti-1400	161	2	am	be	AUX
dti-1400	161	3	soc	soc	NOUN
dti-1400	161	4	nephrol	nephrol	NOUN
dti-1400	161	5	.	.	PUNCT
dti-1400	162	1	1997;8:361–367	1997;8:361–367	NUM
dti-1400	162	2	.	.	NOUN
dti-1400	162	3	28	28	NUM
dti-1400	162	4	.	.	PUNCT
dti-1400	163	1	coca	coca	PROPN
dti-1400	163	2	sg	sg	PROPN
dti-1400	163	3	.	.	PUNCT
dti-1400	163	4	acute	acute	PROPN
dti-1400	163	5	kidney	kidney	PROPN
dti-1400	163	6	injury	injury	NOUN
dti-1400	163	7	in	in	ADP
dti-1400	163	8	elderly	elderly	ADJ
dti-1400	163	9	persons	person	NOUN
dti-1400	163	10	.	.	PUNCT
dti-1400	164	1	am	be	AUX
dti-1400	164	2	j	j	PROPN
dti-1400	164	3	kidney	kidney	PROPN
dti-1400	164	4	dis	dis	PROPN
dti-1400	164	5	.	.	PUNCT
dti-1400	165	1	2010;56	2010;56	NUM
dti-1400	165	2	:	:	PUNCT
dti-1400	166	1	122–131	122–131	NUM
dti-1400	166	2	.	.	NOUN
dti-1400	166	3	29	29	NUM
dti-1400	166	4	.	.	PUNCT
dti-1400	166	5	ando	ando	PROPN
dti-1400	166	6	y	y	PROPN
dti-1400	166	7	,	,	PUNCT
dti-1400	166	8	minami	minami	PROPN
dti-1400	166	9	h	h	PROPN
dti-1400	166	10	,	,	PUNCT
dti-1400	166	11	saka	saka	PROPN
dti-1400	166	12	h	h	PROPN
dti-1400	166	13	,	,	PUNCT
dti-1400	166	14	ando	ando	PROPN
dti-1400	166	15	m	m	PROPN
dti-1400	166	16	,	,	PUNCT
dti-1400	166	17	sakai	sakai	PROPN
dti-1400	166	18	s	s	PROPN
dti-1400	166	19	,	,	PUNCT
dti-1400	166	20	shimokata	shimokata	PROPN
dti-1400	166	21	k.	k.	PROPN
dti-1400	166	22	adjustment	adjustment	PROPN
dti-1400	166	23	of	of	ADP
dti-1400	166	24	creatinine	creatinine	NOUN
dti-1400	166	25	clearance	clearance	NOUN
dti-1400	166	26	improves	improve	VERB
dti-1400	166	27	accuracy	accuracy	NOUN
dti-1400	166	28	of	of	ADP
dti-1400	166	29	calvert	calvert	NOUN
dti-1400	166	30	’s	’s	PART
dti-1400	166	31	formula	formula	NOUN
dti-1400	166	32	for	for	ADP
dti-1400	166	33	carboplatin	carboplatin	NOUN
dti-1400	166	34	dosing	dosing	NOUN
dti-1400	166	35	.	.	PUNCT
dti-1400	167	1	br	br	PROPN
dti-1400	167	2	j	j	PROPN
dti-1400	167	3	cancer	cancer	NOUN
dti-1400	167	4	.	.	PUNCT
dti-1400	168	1	1997;76:1067–1071	1997;76:1067–1071	ADJ
dti-1400	168	2	.	.	PUNCT
dti-1400	169	1	30	30	NUM
dti-1400	169	2	.	.	PUNCT
dti-1400	170	1	delanaye	delanaye	VERB
dti-1400	170	2	p	p	NOUN
dti-1400	170	3	,	,	PUNCT
dti-1400	170	4	cavalier	cavalier	ADJ
dti-1400	170	5	e	e	NOUN
dti-1400	170	6	,	,	PUNCT
dti-1400	170	7	pottel	pottel	PROPN
dti-1400	170	8	h.	h.	PROPN
dti-1400	170	9	serum	serum	PROPN
dti-1400	170	10	creatinine	creatinine	PROPN
dti-1400	170	11	:	:	PUNCT
dti-1400	170	12	not	not	PART
dti-1400	170	13	so	so	ADV
dti-1400	170	14	simple	simple	ADJ
dti-1400	170	15	!	!	PUNCT
dti-1400	171	1	nephron	nephron	NOUN
dti-1400	171	2	.	.	PUNCT
dti-1400	172	1	2017;136:302–308	2017;136:302–308	X
dti-1400	172	2	.	.	PUNCT
dti-1400	173	1	31	31	NUM
dti-1400	173	2	.	.	PUNCT
dti-1400	174	1	adair	adair	PROPN
dti-1400	174	2	jc	jc	PROPN
dti-1400	174	3	,	,	PUNCT
dti-1400	174	4	gold	gold	NOUN
dti-1400	174	5	m	m	NOUN
dti-1400	174	6	,	,	PUNCT
dti-1400	174	7	bond	bond	NOUN
dti-1400	174	8	re	re	NOUN
dti-1400	174	9	.	.	PUNCT
dti-1400	175	1	acyclovir	acyclovir	PROPN
dti-1400	175	2	neurotoxicity	neurotoxicity	PROPN
dti-1400	175	3	:	:	PUNCT
dti-1400	175	4	clinical	clinical	ADJ
dti-1400	175	5	experience	experience	NOUN
dti-1400	175	6	and	and	CCONJ
dti-1400	175	7	review	review	NOUN
dti-1400	175	8	of	of	ADP
dti-1400	175	9	the	the	DET
dti-1400	175	10	literature	literature	NOUN
dti-1400	175	11	.	.	PUNCT
dti-1400	176	1	south	south	PROPN
dti-1400	176	2	med	med	PROPN
dti-1400	176	3	j.	j.	PROPN
dti-1400	176	4	1994;87:1227–1231	1994;87:1227–1231	PROPN
dti-1400	176	5	.	.	PROPN
dti-1400	177	1	32	32	NUM
dti-1400	177	2	.	.	PUNCT
dti-1400	178	1	collins	collins	PROPN
dti-1400	178	2	a	a	PRON
dti-1400	178	3	,	,	PUNCT
dti-1400	178	4	krieff	krieff	PROPN
dti-1400	178	5	d	d	PROPN
dti-1400	178	6	,	,	PUNCT
dti-1400	178	7	smith	smith	PROPN
dti-1400	178	8	c	c	PROPN
dti-1400	178	9	,	,	PUNCT
dti-1400	178	10	singer	singer	NOUN
dti-1400	178	11	c.	c.	PROPN
dti-1400	178	12	neuropsychiatric	neuropsychiatric	ADJ
dti-1400	178	13	toxicity	toxicity	NOUN
dti-1400	178	14	in	in	ADP
dti-1400	178	15	a	a	DET
dti-1400	178	16	patient	patient	NOUN
dti-1400	178	17	undergoing	undergo	VERB
dti-1400	178	18	hemodialysis	hemodialysis	NOUN
dti-1400	178	19	and	and	CCONJ
dti-1400	178	20	receiving	receive	VERB
dti-1400	178	21	treatment	treatment	NOUN
dti-1400	178	22	with	with	ADP
dti-1400	178	23	oral	oral	ADJ
dti-1400	178	24	acyclovir	acyclovir	PROPN
dti-1400	178	25	.	.	PUNCT
dti-1400	179	1	clin	clin	PROPN
dti-1400	179	2	infect	infect	PROPN
dti-1400	179	3	dis	dis	PROPN
dti-1400	179	4	.	.	PUNCT
dti-1400	180	1	1996;22:187–188	1996;22:187–188	X
dti-1400	180	2	.	.	PUNCT
dti-1400	181	1	33	33	NUM
dti-1400	181	2	.	.	PUNCT
dti-1400	182	1	pouplin	pouplin	PROPN
dti-1400	182	2	t	t	PROPN
dti-1400	182	3	,	,	PUNCT
dti-1400	182	4	pouplin	pouplin	PROPN
dti-1400	182	5	jn	jn	PROPN
dti-1400	182	6	,	,	PUNCT
dti-1400	182	7	van	van	PROPN
dti-1400	182	8	toi	toi	PROPN
dti-1400	182	9	p	p	X
dti-1400	182	10	,	,	PUNCT
dti-1400	182	11	et	et	PROPN
dti-1400	182	12	al	al	PROPN
dti-1400	182	13	.	.	PROPN
dti-1400	182	14	valacyclovir	valacyclovir	PROPN
dti-1400	182	15	for	for	ADP
dti-1400	182	16	herpes	herpe	NOUN
dti-1400	182	17	simplex	simplex	NOUN
dti-1400	182	18	encephalitis	encephalitis	NOUN
dti-1400	182	19	.	.	PUNCT
dti-1400	183	1	antimicrob	antimicrob	PROPN
dti-1400	183	2	agents	agents	PROPN
dti-1400	183	3	chemother	chemother	PROPN
dti-1400	183	4	.	.	PUNCT
dti-1400	184	1	2011;55:3624–3626	2011;55:3624–3626	NUM
dti-1400	184	2	.	.	NOUN
dti-1400	185	1	34	34	NUM
dti-1400	185	2	.	.	X
dti-1400	185	3	de	de	PROPN
dti-1400	185	4	knegt	knegt	PROPN
dti-1400	185	5	rj	rj	PROPN
dti-1400	185	6	,	,	PUNCT
dti-1400	185	7	van	van	PROPN
dti-1400	185	8	der	der	PROPN
dti-1400	185	9	pijl	pijl	PROPN
dti-1400	185	10	h	h	PROPN
dti-1400	185	11	,	,	PUNCT
dti-1400	185	12	van	van	PROPN
dti-1400	185	13	es	es	NOUN
dti-1400	185	14	la	la	PROPN
dti-1400	185	15	.	.	PUNCT
dti-1400	185	16	acyclovir	acyclovir	PROPN
dti-1400	185	17	-	-	PUNCT
dti-1400	185	18	associated	associate	VERB
dti-1400	185	19	encephalopathy	encephalopathy	NOUN
dti-1400	185	20	,	,	PUNCT
dti-1400	185	21	lack	lack	NOUN
dti-1400	185	22	of	of	ADP
dti-1400	185	23	relationship	relationship	NOUN
dti-1400	185	24	between	between	ADP
dti-1400	185	25	acyclovir	acyclovir	PROPN
dti-1400	185	26	levels	level	NOUN
dti-1400	185	27	and	and	CCONJ
dti-1400	185	28	symptoms	symptom	NOUN
dti-1400	185	29	.	.	PUNCT
dti-1400	186	1	nephrol	nephrol	PROPN
dti-1400	186	2	dial	dial	NOUN
dti-1400	186	3	transplant	transplant	NOUN
dti-1400	186	4	.	.	PUNCT
dti-1400	187	1	1995;10:1775–1777	1995;10:1775–1777	NUM
dti-1400	187	2	.	.	PUNCT
dti-1400	188	1	35	35	NUM
dti-1400	188	2	.	.	PUNCT
dti-1400	189	1	helldén	helldén	PROPN
dti-1400	189	2	a	a	DET
dti-1400	189	3	,	,	PUNCT
dti-1400	189	4	odar	odar	NOUN
dti-1400	189	5	-	-	PUNCT
dti-1400	189	6	cederlöf	cederlöf	NOUN
dti-1400	189	7	i	i	PROPN
dti-1400	189	8	,	,	PUNCT
dti-1400	189	9	diener	diener	PROPN
dti-1400	189	10	p	p	PROPN
dti-1400	189	11	,	,	PUNCT
dti-1400	189	12	et	et	PROPN
dti-1400	189	13	al	al	PROPN
dti-1400	189	14	.	.	PROPN
dti-1400	190	1	high	high	PROPN
dti-1400	190	2	serum	serum	NOUN
dti-1400	190	3	concentrations	concentration	NOUN
dti-1400	190	4	of	of	ADP
dti-1400	190	5	the	the	DET
dti-1400	190	6	acyclovir	acyclovir	PROPN
dti-1400	190	7	main	main	ADJ
dti-1400	190	8	metabolite	metabolite	NOUN
dti-1400	190	9	9	9	NUM
dti-1400	190	10	-	-	PUNCT
dti-1400	190	11	carboxymethoxymethylguanine	carboxymethoxymethylguanine	NOUN
dti-1400	190	12	in	in	ADP
dti-1400	190	13	renal	renal	ADJ
dti-1400	190	14	failure	failure	NOUN
dti-1400	190	15	patients	patient	NOUN
dti-1400	190	16	with	with	ADP
dti-1400	190	17	acyclovir	acyclovir	PROPN
dti-1400	190	18	-	-	PUNCT
dti-1400	190	19	related	relate	VERB
dti-1400	190	20	neuropsychiatric	neuropsychiatric	ADJ
dti-1400	190	21	side	side	NOUN
dti-1400	190	22	effects	effect	NOUN
dti-1400	190	23	:	:	PUNCT
dti-1400	190	24	an	an	DET
dti-1400	190	25	observational	observational	ADJ
dti-1400	190	26	study	study	NOUN
dti-1400	190	27	.	.	PUNCT
dti-1400	191	1	nephrol	nephrol	PROPN
dti-1400	191	2	dial	dial	NOUN
dti-1400	191	3	transplant	transplant	NOUN
dti-1400	191	4	.	.	PUNCT
dti-1400	192	1	2003;18:1135–1141	2003;18:1135–1141	NUM
dti-1400	192	2	.	.	PUNCT
dti-1400	193	1	36	36	NUM
dti-1400	193	2	.	.	PUNCT
dti-1400	194	1	fleischer	fleischer	PROPN
dti-1400	194	2	r	r	PROPN
dti-1400	194	3	,	,	PUNCT
dti-1400	194	4	johnson	johnson	PROPN
dti-1400	194	5	m.	m.	PROPN
dti-1400	194	6	acyclovir	acyclovir	PROPN
dti-1400	194	7	nephrotoxicity	nephrotoxicity	PROPN
dti-1400	194	8	:	:	PUNCT
dti-1400	194	9	a	a	DET
dti-1400	194	10	case	case	NOUN
dti-1400	194	11	report	report	NOUN
dti-1400	194	12	highlighting	highlight	VERB
dti-1400	194	13	the	the	DET
dti-1400	194	14	importance	importance	NOUN
dti-1400	194	15	of	of	ADP
dti-1400	194	16	prevention	prevention	NOUN
dti-1400	194	17	,	,	PUNCT
dti-1400	194	18	detection	detection	NOUN
dti-1400	194	19	,	,	PUNCT
dti-1400	194	20	and	and	CCONJ
dti-1400	194	21	treatment	treatment	NOUN
dti-1400	194	22	of	of	ADP
dti-1400	194	23	acyclovir	acyclovir	PROPN
dti-1400	194	24	-	-	PUNCT
dti-1400	194	25	induced	induce	VERB
dti-1400	194	26	nephropathy	nephropathy	NOUN
dti-1400	194	27	.	.	PUNCT
dti-1400	195	1	case	case	NOUN
dti-1400	195	2	rep	rep	PROPN
dti-1400	195	3	med	med	PROPN
dti-1400	195	4	.	.	PUNCT
dti-1400	196	1	2010;2010:602783	2010;2010:602783	NUM
dti-1400	196	2	.	.	PUNCT
dti-1400	197	1	37	37	NUM
dti-1400	197	2	.	.	PUNCT
dti-1400	198	1	htwe	htwe	PROPN
dti-1400	198	2	th	th	PROPN
dti-1400	198	3	,	,	PUNCT
dti-1400	198	4	bergman	bergman	PROPN
dti-1400	198	5	s	s	PROPN
dti-1400	198	6	,	,	PUNCT
dti-1400	198	7	koirala	koirala	PROPN
dti-1400	198	8	j.	j.	PROPN
dti-1400	198	9	famciclovir	famciclovir	PROPN
dti-1400	198	10	substitution	substitution	NOUN
dti-1400	198	11	for	for	ADP
dti-1400	198	12	patients	patient	NOUN
dti-1400	198	13	with	with	ADP
dti-1400	198	14	acyclovir	acyclovir	PROPN
dti-1400	198	15	-	-	PUNCT
dti-1400	198	16	associated	associate	VERB
dti-1400	198	17	renal	renal	ADJ
dti-1400	198	18	toxicity	toxicity	NOUN
dti-1400	198	19	.	.	PUNCT
dti-1400	199	1	j	j	PROPN
dti-1400	199	2	infect	infect	VERB
dti-1400	199	3	.	.	PUNCT
dti-1400	200	1	2008;57:266–268	2008;57:266–268	X
dti-1400	200	2	.	.	PUNCT
dti-1400	201	1	38	38	NUM
dti-1400	201	2	.	.	PUNCT
dti-1400	202	1	yoon	yoon	PROPN
dti-1400	202	2	h	h	PROPN
dti-1400	202	3	,	,	PUNCT
dti-1400	202	4	rhew	rhew	PROPN
dti-1400	202	5	ky	ky	PROPN
dti-1400	202	6	.	.	PUNCT
dti-1400	202	7	famciclovir	famciclovir	PROPN
dti-1400	203	1	as	as	ADP
dti-1400	203	2	an	an	DET
dti-1400	203	3	antiviral	antiviral	ADJ
dti-1400	203	4	agent	agent	NOUN
dti-1400	203	5	for	for	ADP
dti-1400	203	6	a	a	DET
dti-1400	203	7	patient	patient	NOUN
dti-1400	203	8	with	with	ADP
dti-1400	203	9	acute	acute	ADJ
dti-1400	203	10	renal	renal	ADJ
dti-1400	203	11	failure	failure	NOUN
dti-1400	203	12	.	.	PUNCT
dti-1400	204	1	int	int	PROPN
dti-1400	205	1	j	j	PROPN
dti-1400	205	2	clin	clin	PROPN
dti-1400	205	3	pharm	pharm	PROPN
dti-1400	205	4	.	.	PUNCT
dti-1400	206	1	2013;35:173–175	2013;35:173–175	NUM
dti-1400	206	2	.	.	PUNCT
dti-1400	207	1	39	39	NUM
dti-1400	207	2	.	.	PUNCT
dti-1400	208	1	gales	gale	NOUN
dti-1400	208	2	bj	bj	VERB
dti-1400	208	3	,	,	PUNCT
dti-1400	208	4	gales	gales	PROPN
dti-1400	208	5	ma	ma	PROPN
dti-1400	208	6	.	.	PROPN
dti-1400	208	7	confusion	confusion	PROPN
dti-1400	208	8	and	and	CCONJ
dti-1400	208	9	bradykinesia	bradykinesia	PROPN
dti-1400	208	10	associated	associate	VERB
dti-1400	208	11	with	with	ADP
dti-1400	208	12	famciclovir	famciclovir	PROPN
dti-1400	208	13	therapy	therapy	NOUN
dti-1400	208	14	for	for	ADP
dti-1400	208	15	herpes	herpe	NOUN
dti-1400	208	16	zoster	zoster	NOUN
dti-1400	208	17	.	.	PUNCT
dti-1400	209	1	am	be	AUX
dti-1400	209	2	j	j	PROPN
dti-1400	209	3	health	health	PROPN
dti-1400	209	4	syst	syst	PROPN
dti-1400	209	5	pharm	pharm	PROPN
dti-1400	209	6	.	.	PUNCT
dti-1400	210	1	1996;53:1454	1996;53:1454	NUM
dti-1400	210	2	,	,	PUNCT
dti-1400	210	3	1456	1456	NUM
dti-1400	210	4	.	.	PUNCT