id	sid	tid	token	lemma	pos
dti-1407	1	1	9drug	9drug	NUM
dti-1407	1	2	target	target	NOUN
dti-1407	1	3	insights	insight	VERB
dti-1407	1	4	2015:9	2015:9	PRON
dti-1407	1	5	medicinal	medicinal	ADJ
dti-1407	1	6	plants	plant	NOUN
dti-1407	1	7	:	:	PUNCT
dti-1407	1	8	a	a	DET
dti-1407	1	9	potential	potential	ADJ
dti-1407	1	10	source	source	NOUN
dti-1407	1	11	of	of	ADP
dti-1407	1	12	compounds	compound	NOUN
dti-1407	1	13	for	for	ADP
dti-1407	1	14	targeting	target	VERB
dti-1407	1	15	cell	cell	NOUN
dti-1407	1	16	division	division	NOUN
dti-1407	1	17	ihsan	ihsan	PROPN
dti-1407	1	18	n.	n.	PROPN
dti-1407	1	19	zulkipli	zulkipli	PROPN
dti-1407	1	20	,	,	PUNCT
dti-1407	1	21	sheba	sheba	PROPN
dti-1407	1	22	r.	r.	PROPN
dti-1407	1	23	david	david	PROPN
dti-1407	1	24	,	,	PUNCT
dti-1407	1	25	rajan	rajan	PROPN
dti-1407	1	26	rajabalaya	rajabalaya	PROPN
dti-1407	1	27	and	and	CCONJ
dti-1407	1	28	adi	adi	PROPN
dti-1407	1	29	idris	idris	PROPN
dti-1407	1	30	pap	pap	PROPN
dti-1407	1	31	rashidah	rashidah	PROPN
dti-1407	1	32	sa’adatul	sa’adatul	PRON
dti-1407	1	33	bolkiah	bolkiah	PROPN
dti-1407	1	34	institute	institute	PROPN
dti-1407	1	35	of	of	ADP
dti-1407	1	36	health	health	PROPN
dti-1407	1	37	sciences	sciences	PROPN
dti-1407	1	38	,	,	PUNCT
dti-1407	1	39	universiti	universiti	PROPN
dti-1407	1	40	brunei	brunei	PROPN
dti-1407	1	41	darussalam	darussalam	PROPN
dti-1407	1	42	,	,	PUNCT
dti-1407	1	43	gadong	gadong	PROPN
dti-1407	1	44	,	,	PUNCT
dti-1407	1	45	brunei	brunei	PROPN
dti-1407	1	46	 	 	SPACE
dti-1407	1	47	darussalam	darussalam	PROPN
dti-1407	1	48	.	.	PUNCT
dti-1407	2	1	abstr	abstr	PROPN
dti-1407	2	2	act	act	PROPN
dti-1407	2	3	:	:	PUNCT
dti-1407	2	4	modern	modern	ADJ
dti-1407	2	5	medicinal	medicinal	ADJ
dti-1407	2	6	plant	plant	NOUN
dti-1407	2	7	drug	drug	NOUN
dti-1407	2	8	discovery	discovery	NOUN
dti-1407	2	9	has	have	AUX
dti-1407	2	10	provided	provide	VERB
dti-1407	2	11	pharmacologically	pharmacologically	ADV
dti-1407	2	12	active	active	ADJ
dti-1407	2	13	compounds	compound	NOUN
dti-1407	2	14	targeted	target	VERB
dti-1407	2	15	against	against	ADP
dti-1407	2	16	a	a	DET
dti-1407	2	17	multitude	multitude	NOUN
dti-1407	2	18	of	of	ADP
dti-1407	2	19	conditions	condition	NOUN
dti-1407	2	20	and	and	CCONJ
dti-1407	2	21	diseases	disease	NOUN
dti-1407	2	22	,	,	PUNCT
dti-1407	2	23	such	such	ADJ
dti-1407	2	24	as	as	ADP
dti-1407	2	25	infection	infection	NOUN
dti-1407	2	26	,	,	PUNCT
dti-1407	2	27	inflammation	inflammation	NOUN
dti-1407	2	28	,	,	PUNCT
dti-1407	2	29	and	and	CCONJ
dti-1407	2	30	cancer	cancer	NOUN
dti-1407	2	31	.	.	PUNCT
dti-1407	3	1	to	to	ADP
dti-1407	3	2	date	date	NOUN
dti-1407	3	3	,	,	PUNCT
dti-1407	3	4	natural	natural	ADJ
dti-1407	3	5	products	product	NOUN
dti-1407	3	6	from	from	ADP
dti-1407	3	7	medicinal	medicinal	ADJ
dti-1407	3	8	plants	plant	NOUN
dti-1407	3	9	remain	remain	VERB
dti-1407	3	10	a	a	DET
dti-1407	3	11	solid	solid	ADJ
dti-1407	3	12	niche	niche	NOUN
dti-1407	3	13	as	as	ADP
dti-1407	3	14	a	a	DET
dti-1407	3	15	source	source	NOUN
dti-1407	3	16	from	from	ADP
dti-1407	3	17	which	which	PRON
dti-1407	3	18	cancer	cancer	NOUN
dti-1407	3	19	therapies	therapy	NOUN
dti-1407	3	20	can	can	AUX
dti-1407	3	21	be	be	AUX
dti-1407	3	22	derived	derive	VERB
dti-1407	3	23	.	.	PUNCT
dti-1407	4	1	among	among	ADP
dti-1407	4	2	other	other	ADJ
dti-1407	4	3	properties	property	NOUN
dti-1407	4	4	,	,	PUNCT
dti-1407	4	5	one	one	NUM
dti-1407	4	6	favorable	favorable	ADJ
dti-1407	4	7	characteristic	characteristic	NOUN
dti-1407	4	8	of	of	ADP
dti-1407	4	9	an	an	DET
dti-1407	4	10	anticancer	anticancer	NOUN
dti-1407	4	11	drug	drug	NOUN
dti-1407	4	12	is	be	AUX
dti-1407	4	13	its	its	PRON
dti-1407	4	14	ability	ability	NOUN
dti-1407	4	15	to	to	PART
dti-1407	4	16	block	block	VERB
dti-1407	4	17	the	the	DET
dti-1407	4	18	uncontrollable	uncontrollable	ADJ
dti-1407	4	19	process	process	NOUN
dti-1407	4	20	of	of	ADP
dti-1407	4	21	cell	cell	NOUN
dti-1407	4	22	division	division	NOUN
dti-1407	4	23	,	,	PUNCT
dti-1407	4	24	as	as	SCONJ
dti-1407	4	25	cancer	cancer	NOUN
dti-1407	4	26	cells	cell	NOUN
dti-1407	4	27	are	be	AUX
dti-1407	4	28	notorious	notorious	ADJ
dti-1407	4	29	for	for	ADP
dti-1407	4	30	their	their	PRON
dti-1407	4	31	abnormal	abnormal	ADJ
dti-1407	4	32	cell	cell	NOUN
dti-1407	4	33	division	division	NOUN
dti-1407	4	34	.	.	PUNCT
dti-1407	5	1	there	there	PRON
dti-1407	5	2	are	be	VERB
dti-1407	5	3	numerous	numerous	ADJ
dti-1407	5	4	other	other	ADJ
dti-1407	5	5	documented	document	VERB
dti-1407	5	6	works	work	NOUN
dti-1407	5	7	on	on	ADP
dti-1407	5	8	the	the	DET
dti-1407	5	9	potential	potential	ADJ
dti-1407	5	10	anticancer	anticancer	NOUN
dti-1407	5	11	activity	activity	NOUN
dti-1407	5	12	of	of	ADP
dti-1407	5	13	drugs	drug	NOUN
dti-1407	5	14	derived	derive	VERB
dti-1407	5	15	from	from	ADP
dti-1407	5	16	medicinal	medicinal	ADJ
dti-1407	5	17	plants	plant	NOUN
dti-1407	5	18	,	,	PUNCT
dti-1407	5	19	and	and	CCONJ
dti-1407	5	20	their	their	PRON
dti-1407	5	21	effects	effect	NOUN
dti-1407	5	22	on	on	ADP
dti-1407	5	23	cell	cell	NOUN
dti-1407	5	24	division	division	NOUN
dti-1407	5	25	are	be	AUX
dti-1407	5	26	an	an	DET
dti-1407	5	27	attractive	attractive	ADJ
dti-1407	5	28	and	and	CCONJ
dti-1407	5	29	growing	grow	VERB
dti-1407	5	30	therapeutic	therapeutic	ADJ
dti-1407	5	31	target	target	NOUN
dti-1407	5	32	.	.	PUNCT
dti-1407	6	1	despite	despite	SCONJ
dti-1407	6	2	this	this	PRON
dti-1407	6	3	,	,	PUNCT
dti-1407	6	4	there	there	PRON
dti-1407	6	5	remains	remain	VERB
dti-1407	6	6	a	a	DET
dti-1407	6	7	vast	vast	ADJ
dti-1407	6	8	number	number	NOUN
dti-1407	6	9	of	of	ADP
dti-1407	6	10	unidentified	unidentified	ADJ
dti-1407	6	11	natural	natural	ADJ
dti-1407	6	12	products	product	NOUN
dti-1407	6	13	that	that	PRON
dti-1407	6	14	are	be	AUX
dti-1407	6	15	potentially	potentially	ADV
dti-1407	6	16	promising	promise	VERB
dti-1407	6	17	sources	source	NOUN
dti-1407	6	18	for	for	ADP
dti-1407	6	19	medical	medical	ADJ
dti-1407	6	20	applications	application	NOUN
dti-1407	6	21	.	.	PUNCT
dti-1407	7	1	this	this	DET
dti-1407	7	2	mini	mini	ADJ
dti-1407	7	3	review	review	NOUN
dti-1407	7	4	aims	aim	VERB
dti-1407	7	5	to	to	PART
dti-1407	7	6	revise	revise	VERB
dti-1407	7	7	the	the	DET
dti-1407	7	8	current	current	ADJ
dti-1407	7	9	knowledge	knowledge	NOUN
dti-1407	7	10	of	of	ADP
dti-1407	7	11	the	the	DET
dti-1407	7	12	effects	effect	NOUN
dti-1407	7	13	of	of	ADP
dti-1407	7	14	natural	natural	ADJ
dti-1407	7	15	plant	plant	NOUN
dti-1407	7	16	products	product	NOUN
dti-1407	7	17	on	on	ADP
dti-1407	7	18	cell	cell	NOUN
dti-1407	7	19	division	division	NOUN
dti-1407	7	20	.	.	PUNCT
dti-1407	8	1	key	key	ADJ
dti-1407	8	2	words	word	NOUN
dti-1407	8	3	:	:	PUNCT
dti-1407	8	4	cell	cell	NOUN
dti-1407	8	5	division	division	NOUN
dti-1407	8	6	,	,	PUNCT
dti-1407	8	7	cancer	cancer	NOUN
dti-1407	8	8	,	,	PUNCT
dti-1407	8	9	medicinal	medicinal	ADJ
dti-1407	8	10	plants	plant	NOUN
dti-1407	8	11	,	,	PUNCT
dti-1407	8	12	microtubule	microtubule	NOUN
dti-1407	8	13	,	,	PUNCT
dti-1407	8	14	natural	natural	ADJ
dti-1407	8	15	products	product	NOUN
dti-1407	8	16	citation	citation	NOUN
dti-1407	8	17	:	:	PUNCT
dti-1407	8	18	zulkipli	zulkipli	NUM
dti-1407	8	19	et	et	PROPN
dti-1407	8	20	al	al	PROPN
dti-1407	8	21	.	.	PUNCT
dti-1407	9	1	medicinal	medicinal	ADJ
dti-1407	9	2	plants	plant	NOUN
dti-1407	9	3	:	:	PUNCT
dti-1407	9	4	a	a	DET
dti-1407	9	5	potential	potential	ADJ
dti-1407	9	6	source	source	NOUN
dti-1407	9	7	of	of	ADP
dti-1407	9	8	compounds	compound	NOUN
dti-1407	9	9	for	for	ADP
dti-1407	9	10	targeting	target	VERB
dti-1407	9	11	cell	cell	NOUN
dti-1407	9	12	division	division	NOUN
dti-1407	9	13	.	.	PUNCT
dti-1407	10	1	drug	drug	NOUN
dti-1407	10	2	target	target	NOUN
dti-1407	10	3	insights	insight	VERB
dti-1407	10	4	2015:9	2015:9	PRON
dti-1407	10	5	9–19	9–19	NOUN
dti-1407	10	6	doi:10.4137	doi:10.4137	NOUN
dti-1407	10	7	/	/	SYM
dti-1407	10	8	dti.s24946	dti.s24946	NOUN
dti-1407	10	9	.	.	PUNCT
dti-1407	11	1	received	receive	VERB
dti-1407	11	2	:	:	PUNCT
dti-1407	11	3	february	february	PROPN
dti-1407	11	4	13	13	NUM
dti-1407	11	5	,	,	PUNCT
dti-1407	11	6	2015	2015	NUM
dti-1407	11	7	.	.	PUNCT
dti-1407	12	1	resubmitted	resubmitte	VERB
dti-1407	12	2	:	:	PUNCT
dti-1407	12	3	april	april	PROPN
dti-1407	12	4	7	7	NUM
dti-1407	12	5	,	,	PUNCT
dti-1407	12	6	2015	2015	NUM
dti-1407	12	7	.	.	PUNCT
dti-1407	13	1	accepted	accept	VERB
dti-1407	13	2	for	for	ADP
dti-1407	13	3	publication	publication	NOUN
dti-1407	13	4	:	:	PUNCT
dti-1407	13	5	april	april	PROPN
dti-1407	13	6	20	20	NUM
dti-1407	13	7	,	,	PUNCT
dti-1407	13	8	2015	2015	NUM
dti-1407	13	9	.	.	PUNCT
dti-1407	14	1	academic	academic	ADJ
dti-1407	14	2	editor	editor	NOUN
dti-1407	14	3	:	:	PUNCT
dti-1407	14	4	anuj	anuj	PROPN
dti-1407	14	5	chauhan	chauhan	PROPN
dti-1407	14	6	,	,	PUNCT
dti-1407	14	7	editor	editor	NOUN
dti-1407	14	8	in	in	ADP
dti-1407	14	9	chief	chief	ADJ
dti-1407	14	10	type	type	NOUN
dti-1407	14	11	:	:	PUNCT
dti-1407	14	12	short	short	ADJ
dti-1407	14	13	review	review	NOUN
dti-1407	14	14	funding	funding	NOUN
dti-1407	14	15	:	:	PUNCT
dti-1407	14	16	we	we	PRON
dti-1407	14	17	would	would	AUX
dti-1407	14	18	like	like	VERB
dti-1407	14	19	to	to	PART
dti-1407	14	20	thank	thank	VERB
dti-1407	14	21	the	the	DET
dti-1407	14	22	universiti	universiti	PROPN
dti-1407	14	23	brunei	brunei	PROPN
dti-1407	14	24	darussalam	darussalam	PROPN
dti-1407	14	25	(	(	PUNCT
dti-1407	14	26	ubd	ubd	PROPN
dti-1407	14	27	)	)	PUNCT
dti-1407	14	28	research	research	NOUN
dti-1407	14	29	grant	grant	NOUN
dti-1407	14	30	(	(	PUNCT
dti-1407	14	31	ubcd	ubcd	NOUN
dti-1407	14	32	/	/	SYM
dti-1407	14	33	pnc2/2	pnc2/2	PROPN
dti-1407	14	34	/	/	SYM
dti-1407	14	35	rg/1(322	rg/1(322	NOUN
dti-1407	14	36	)	)	PUNCT
dti-1407	14	37	)	)	PUNCT
dti-1407	14	38	for	for	ADP
dti-1407	14	39	funding	fund	VERB
dti-1407	14	40	this	this	DET
dti-1407	14	41	research	research	NOUN
dti-1407	14	42	.	.	PUNCT
dti-1407	15	1	the	the	DET
dti-1407	15	2	authors	author	NOUN
dti-1407	15	3	confirm	confirm	VERB
dti-1407	15	4	that	that	SCONJ
dti-1407	15	5	the	the	DET
dti-1407	15	6	funder	funder	NOUN
dti-1407	15	7	had	have	VERB
dti-1407	15	8	no	no	DET
dti-1407	15	9	influence	influence	NOUN
dti-1407	15	10	over	over	ADP
dti-1407	15	11	the	the	DET
dti-1407	15	12	study	study	NOUN
dti-1407	15	13	design	design	NOUN
dti-1407	15	14	,	,	PUNCT
dti-1407	15	15	content	content	NOUN
dti-1407	15	16	of	of	ADP
dti-1407	15	17	the	the	DET
dti-1407	15	18	article	article	NOUN
dti-1407	15	19	,	,	PUNCT
dti-1407	15	20	or	or	CCONJ
dti-1407	15	21	selection	selection	NOUN
dti-1407	15	22	of	of	ADP
dti-1407	15	23	this	this	DET
dti-1407	15	24	journal	journal	NOUN
dti-1407	15	25	.	.	PUNCT
dti-1407	16	1	competing	compete	VERB
dti-1407	16	2	interests	interest	NOUN
dti-1407	16	3	:	:	PUNCT
dti-1407	16	4	authors	author	NOUN
dti-1407	16	5	disclose	disclose	VERB
dti-1407	16	6	no	no	DET
dti-1407	16	7	potential	potential	ADJ
dti-1407	16	8	conflicts	conflict	NOUN
dti-1407	16	9	of	of	ADP
dti-1407	16	10	interest	interest	NOUN
dti-1407	16	11	.	.	PUNCT
dti-1407	17	1	copyright	copyright	NOUN
dti-1407	17	2	:	:	PUNCT
dti-1407	17	3	©	©	PROPN
dti-1407	17	4	the	the	DET
dti-1407	17	5	authors	author	NOUN
dti-1407	17	6	,	,	PUNCT
dti-1407	17	7	publisher	publisher	NOUN
dti-1407	17	8	and	and	CCONJ
dti-1407	17	9	licensee	licensee	NOUN
dti-1407	17	10	libertas	liberta	NOUN
dti-1407	17	11	academica	academica	PROPN
dti-1407	17	12	limited	limit	VERB
dti-1407	17	13	.	.	PUNCT
dti-1407	18	1	this	this	PRON
dti-1407	18	2	is	be	AUX
dti-1407	18	3	an	an	DET
dti-1407	18	4	open	open	ADJ
dti-1407	18	5	-	-	PUNCT
dti-1407	18	6	access	access	NOUN
dti-1407	18	7	article	article	NOUN
dti-1407	18	8	distributed	distribute	VERB
dti-1407	18	9	under	under	ADP
dti-1407	18	10	the	the	DET
dti-1407	18	11	terms	term	NOUN
dti-1407	18	12	of	of	ADP
dti-1407	18	13	the	the	DET
dti-1407	18	14	creative	creative	ADJ
dti-1407	18	15	commons	common	NOUN
dti-1407	18	16	cc	cc	NOUN
dti-1407	18	17	-	-	PUNCT
dti-1407	18	18	by	by	ADP
dti-1407	18	19	-	-	PUNCT
dti-1407	18	20	nc	nc	PROPN
dti-1407	18	21	3.0	3.0	NUM
dti-1407	18	22	license	license	NOUN
dti-1407	18	23	.	.	PUNCT
dti-1407	19	1	correspondence	correspondence	NOUN
dti-1407	19	2	:	:	PUNCT
dti-1407	20	1	yusri.idris@ubd.edu.bn	yusri.idris@ubd.edu.bn	PROPN
dti-1407	20	2	paper	paper	NOUN
dti-1407	20	3	subject	subject	NOUN
dti-1407	20	4	to	to	ADP
dti-1407	20	5	independent	independent	ADJ
dti-1407	20	6	expert	expert	NOUN
dti-1407	20	7	blind	blind	ADJ
dti-1407	20	8	peer	peer	NOUN
dti-1407	20	9	review	review	NOUN
dti-1407	20	10	by	by	ADP
dti-1407	20	11	minimum	minimum	NOUN
dti-1407	20	12	of	of	ADP
dti-1407	20	13	two	two	NUM
dti-1407	20	14	reviewers	reviewer	NOUN
dti-1407	20	15	.	.	PUNCT
dti-1407	21	1	all	all	DET
dti-1407	21	2	editorial	editorial	ADJ
dti-1407	21	3	decisions	decision	NOUN
dti-1407	21	4	made	make	VERB
dti-1407	21	5	by	by	ADP
dti-1407	21	6	independent	independent	ADJ
dti-1407	21	7	academic	academic	ADJ
dti-1407	21	8	editor	editor	NOUN
dti-1407	21	9	.	.	PUNCT
dti-1407	22	1	upon	upon	SCONJ
dti-1407	22	2	submission	submission	NOUN
dti-1407	22	3	manuscript	manuscript	NOUN
dti-1407	22	4	was	be	AUX
dti-1407	22	5	subject	subject	ADJ
dti-1407	22	6	to	to	ADP
dti-1407	22	7	anti	anti	ADJ
dti-1407	22	8	-	-	NOUN
dti-1407	22	9	plagiarism	plagiarism	ADJ
dti-1407	22	10	scanning	scanning	NOUN
dti-1407	22	11	.	.	PUNCT
dti-1407	23	1	prior	prior	ADV
dti-1407	23	2	to	to	ADP
dti-1407	23	3	publication	publication	NOUN
dti-1407	23	4	all	all	DET
dti-1407	23	5	authors	author	NOUN
dti-1407	23	6	have	have	AUX
dti-1407	23	7	given	give	VERB
dti-1407	23	8	signed	sign	VERB
dti-1407	23	9	confirmation	confirmation	NOUN
dti-1407	23	10	of	of	ADP
dti-1407	23	11	agreement	agreement	NOUN
dti-1407	23	12	to	to	ADP
dti-1407	23	13	article	article	NOUN
dti-1407	23	14	publication	publication	NOUN
dti-1407	23	15	and	and	CCONJ
dti-1407	23	16	compliance	compliance	NOUN
dti-1407	23	17	with	with	ADP
dti-1407	23	18	all	all	DET
dti-1407	23	19	applicable	applicable	ADJ
dti-1407	23	20	ethical	ethical	ADJ
dti-1407	23	21	and	and	CCONJ
dti-1407	23	22	legal	legal	ADJ
dti-1407	23	23	requirements	requirement	NOUN
dti-1407	23	24	,	,	PUNCT
dti-1407	23	25	including	include	VERB
dti-1407	23	26	the	the	DET
dti-1407	23	27	accuracy	accuracy	NOUN
dti-1407	23	28	of	of	ADP
dti-1407	23	29	author	author	NOUN
dti-1407	23	30	and	and	CCONJ
dti-1407	23	31	contributor	contributor	NOUN
dti-1407	23	32	information	information	NOUN
dti-1407	23	33	,	,	PUNCT
dti-1407	23	34	disclosure	disclosure	NOUN
dti-1407	23	35	of	of	ADP
dti-1407	23	36	competing	compete	VERB
dti-1407	23	37	interests	interest	NOUN
dti-1407	23	38	and	and	CCONJ
dti-1407	23	39	funding	funding	NOUN
dti-1407	23	40	sources	source	NOUN
dti-1407	23	41	,	,	PUNCT
dti-1407	23	42	compliance	compliance	NOUN
dti-1407	23	43	with	with	ADP
dti-1407	23	44	ethical	ethical	ADJ
dti-1407	23	45	requirements	requirement	NOUN
dti-1407	23	46	relating	relate	VERB
dti-1407	23	47	to	to	ADP
dti-1407	23	48	human	human	ADJ
dti-1407	23	49	and	and	CCONJ
dti-1407	23	50	animal	animal	NOUN
dti-1407	23	51	study	study	NOUN
dti-1407	23	52	participants	participant	NOUN
dti-1407	23	53	,	,	PUNCT
dti-1407	23	54	and	and	CCONJ
dti-1407	23	55	compliance	compliance	NOUN
dti-1407	23	56	with	with	ADP
dti-1407	23	57	any	any	DET
dti-1407	23	58	copyright	copyright	NOUN
dti-1407	23	59	requirements	requirement	NOUN
dti-1407	23	60	of	of	ADP
dti-1407	23	61	third	third	ADJ
dti-1407	23	62	parties	party	NOUN
dti-1407	23	63	.	.	PUNCT
dti-1407	24	1	this	this	DET
dti-1407	24	2	journal	journal	NOUN
dti-1407	24	3	is	be	AUX
dti-1407	24	4	a	a	DET
dti-1407	24	5	member	member	NOUN
dti-1407	24	6	of	of	ADP
dti-1407	24	7	the	the	DET
dti-1407	24	8	committee	committee	NOUN
dti-1407	24	9	on	on	ADP
dti-1407	24	10	publication	publication	NOUN
dti-1407	24	11	ethics	ethic	NOUN
dti-1407	24	12	(	(	PUNCT
dti-1407	24	13	cope	cope	PROPN
dti-1407	24	14	)	)	PUNCT
dti-1407	24	15	.	.	PUNCT
dti-1407	25	1	published	publish	VERB
dti-1407	25	2	by	by	ADP
dti-1407	25	3	libertas	liberta	NOUN
dti-1407	25	4	academica	academica	PROPN
dti-1407	25	5	.	.	PUNCT
dti-1407	26	1	learn	learn	VERB
dti-1407	26	2	more	more	ADJ
dti-1407	26	3	about	about	ADP
dti-1407	26	4	this	this	DET
dti-1407	26	5	journal	journal	NOUN
dti-1407	26	6	.	.	PUNCT
dti-1407	27	1	introduction	introduction	NOUN
dti-1407	27	2	human	human	ADJ
dti-1407	27	3	beings	being	NOUN
dti-1407	27	4	have	have	VERB
dti-1407	27	5	long	long	ADV
dti-1407	27	6	used	use	VERB
dti-1407	27	7	plants	plant	NOUN
dti-1407	27	8	as	as	ADP
dti-1407	27	9	a	a	DET
dti-1407	27	10	medicinal	medicinal	ADJ
dti-1407	27	11	source	source	NOUN
dti-1407	27	12	.	.	PUNCT
dti-1407	28	1	their	their	PRON
dti-1407	28	2	use	use	NOUN
dti-1407	28	3	has	have	AUX
dti-1407	28	4	grown	grow	VERB
dti-1407	28	5	more	more	ADV
dti-1407	28	6	sophisticated	sophisticated	ADJ
dti-1407	28	7	with	with	ADP
dti-1407	28	8	modern	modern	ADJ
dti-1407	28	9	chemists	chemist	NOUN
dti-1407	28	10	using	use	VERB
dti-1407	28	11	compounds	compound	NOUN
dti-1407	28	12	isolated	isolate	VERB
dti-1407	28	13	from	from	ADP
dti-1407	28	14	plants	plant	NOUN
dti-1407	28	15	as	as	ADP
dti-1407	28	16	a	a	DET
dti-1407	28	17	basis	basis	NOUN
dti-1407	28	18	for	for	ADP
dti-1407	28	19	generating	generate	VERB
dti-1407	28	20	novel	novel	NOUN
dti-1407	28	21	compounds	compound	NOUN
dti-1407	28	22	with	with	ADP
dti-1407	28	23	additional	additional	ADJ
dti-1407	28	24	benefits	benefit	NOUN
dti-1407	28	25	,	,	PUNCT
dti-1407	28	26	such	such	ADJ
dti-1407	28	27	as	as	ADP
dti-1407	28	28	its	its	PRON
dti-1407	28	29	lower	low	ADJ
dti-1407	28	30	toxicity	toxicity	NOUN
dti-1407	28	31	and	and	CCONJ
dti-1407	28	32	potential	potential	NOUN
dti-1407	28	33	for	for	ADP
dti-1407	28	34	combating	combat	VERB
dti-1407	28	35	drug	drug	NOUN
dti-1407	28	36	-	-	PUNCT
dti-1407	28	37	resistant	resistant	ADJ
dti-1407	28	38	diseases	disease	NOUN
dti-1407	28	39	.	.	PUNCT
dti-1407	29	1	between	between	ADP
dti-1407	29	2	1981	1981	NUM
dti-1407	29	3	and	and	CCONJ
dti-1407	29	4	2010	2010	NUM
dti-1407	29	5	,	,	PUNCT
dti-1407	29	6	naturally	naturally	ADV
dti-1407	29	7	derived	derive	VERB
dti-1407	29	8	products	product	NOUN
dti-1407	29	9	and	and	CCONJ
dti-1407	29	10	their	their	PRON
dti-1407	29	11	mimics	mimic	NOUN
dti-1407	29	12	composed	compose	VERB
dti-1407	29	13	an	an	DET
dti-1407	29	14	estimated	estimate	VERB
dti-1407	29	15	70	70	NUM
dti-1407	29	16	%	%	NOUN
dti-1407	29	17	of	of	ADP
dti-1407	29	18	new	new	ADJ
dti-1407	29	19	chemical	chemical	NOUN
dti-1407	29	20	compounds	compound	NOUN
dti-1407	29	21	reported.1	reported.1	PROPN
dti-1407	29	22	naturally	naturally	ADV
dti-1407	29	23	derived	derive	VERB
dti-1407	29	24	compounds	compound	NOUN
dti-1407	29	25	with	with	ADP
dti-1407	29	26	anticancer	anticancer	NOUN
dti-1407	29	27	activity	activity	NOUN
dti-1407	29	28	have	have	AUX
dti-1407	29	29	also	also	ADV
dti-1407	29	30	been	be	AUX
dti-1407	29	31	used	use	VERB
dti-1407	29	32	as	as	ADP
dti-1407	29	33	the	the	DET
dti-1407	29	34	basis	basis	NOUN
dti-1407	29	35	for	for	ADP
dti-1407	29	36	original	original	ADJ
dti-1407	29	37	synthetic	synthetic	ADJ
dti-1407	29	38	analogs	analog	NOUN
dti-1407	29	39	,	,	PUNCT
dti-1407	29	40	forming	form	VERB
dti-1407	29	41	their	their	PRON
dti-1407	29	42	own	own	ADJ
dti-1407	29	43	novel	novel	ADJ
dti-1407	29	44	class	class	NOUN
dti-1407	29	45	of	of	ADP
dti-1407	29	46	chemical	chemical	NOUN
dti-1407	29	47	compounds.2	compounds.2	PROPN
dti-1407	29	48	mammalian	mammalian	ADJ
dti-1407	29	49	microtubules	microtubule	NOUN
dti-1407	29	50	appear	appear	VERB
dti-1407	29	51	to	to	PART
dti-1407	29	52	be	be	AUX
dti-1407	29	53	a	a	DET
dti-1407	29	54	common	common	ADJ
dti-1407	29	55	target	target	NOUN
dti-1407	29	56	for	for	ADP
dti-1407	29	57	naturally	naturally	ADV
dti-1407	29	58	occurring	occur	VERB
dti-1407	29	59	toxic	toxic	ADJ
dti-1407	29	60	molecules	molecule	NOUN
dti-1407	29	61	produced	produce	VERB
dti-1407	29	62	by	by	ADP
dti-1407	29	63	a	a	DET
dti-1407	29	64	large	large	ADJ
dti-1407	29	65	number	number	NOUN
dti-1407	29	66	of	of	ADP
dti-1407	29	67	flora	flora	NOUN
dti-1407	29	68	,	,	PUNCT
dti-1407	29	69	presumably	presumably	ADV
dti-1407	29	70	with	with	ADP
dti-1407	29	71	the	the	DET
dti-1407	29	72	original	original	ADJ
dti-1407	29	73	intent	intent	NOUN
dti-1407	29	74	of	of	ADP
dti-1407	29	75	self	self	NOUN
dti-1407	29	76	-	-	PUNCT
dti-1407	29	77	defense	defense	NOUN
dti-1407	29	78	.	.	PUNCT
dti-1407	30	1	microtubules	microtubule	NOUN
dti-1407	30	2	are	be	AUX
dti-1407	30	3	a	a	DET
dti-1407	30	4	component	component	NOUN
dti-1407	30	5	of	of	ADP
dti-1407	30	6	the	the	DET
dti-1407	30	7	cytoskeleton	cytoskeleton	NOUN
dti-1407	30	8	,	,	PUNCT
dti-1407	30	9	found	find	VERB
dti-1407	30	10	throughout	throughout	ADP
dti-1407	30	11	the	the	DET
dti-1407	30	12	cell	cell	NOUN
dti-1407	30	13	cytoplasm	cytoplasm	NOUN
dti-1407	30	14	,	,	PUNCT
dti-1407	30	15	which	which	PRON
dti-1407	30	16	is	be	AUX
dti-1407	30	17	important	important	ADJ
dti-1407	30	18	in	in	ADP
dti-1407	30	19	the	the	DET
dti-1407	30	20	process	process	NOUN
dti-1407	30	21	of	of	ADP
dti-1407	30	22	mitosis	mitosis	NOUN
dti-1407	30	23	(	(	PUNCT
dti-1407	30	24	ie	ie	X
dti-1407	30	25	,	,	PUNCT
dti-1407	30	26	cell	cell	NOUN
dti-1407	30	27	division	division	NOUN
dti-1407	30	28	)	)	PUNCT
dti-1407	30	29	.	.	PUNCT
dti-1407	31	1	most	most	ADJ
dti-1407	31	2	microtubule	microtubule	NOUN
dti-1407	31	3	-	-	PUNCT
dti-1407	31	4	targeting	target	VERB
dti-1407	31	5	compounds	compound	NOUN
dti-1407	31	6	have	have	AUX
dti-1407	31	7	been	be	AUX
dti-1407	31	8	discovered	discover	VERB
dti-1407	31	9	in	in	ADP
dti-1407	31	10	large	large	ADJ
dti-1407	31	11	-	-	PUNCT
dti-1407	31	12	scale	scale	NOUN
dti-1407	31	13	screens	screen	NOUN
dti-1407	31	14	of	of	ADP
dti-1407	31	15	natural	natural	ADJ
dti-1407	31	16	products3,4	products3,4	PROPN
dti-1407	31	17	(	(	PUNCT
dti-1407	31	18	table	table	NOUN
dti-1407	31	19	1	1	NUM
dti-1407	31	20	)	)	PUNCT
dti-1407	31	21	.	.	PUNCT
dti-1407	32	1	approximately	approximately	ADV
dti-1407	32	2	75	75	NUM
dti-1407	32	3	%	%	NOUN
dti-1407	32	4	of	of	ADP
dti-1407	32	5	the	the	DET
dti-1407	32	6	available	available	ADJ
dti-1407	32	7	anticancer	anticancer	NOUN
dti-1407	32	8	drugs	drug	NOUN
dti-1407	32	9	between	between	ADP
dti-1407	32	10	1940	1940	NUM
dti-1407	32	11	and	and	CCONJ
dti-1407	32	12	2010	2010	NUM
dti-1407	32	13	were	be	AUX
dti-1407	32	14	naturally	naturally	ADV
dti-1407	32	15	derived	derive	VERB
dti-1407	32	16	products	product	NOUN
dti-1407	32	17	or	or	CCONJ
dti-1407	32	18	their	their	PRON
dti-1407	32	19	mimics	mimic	NOUN
dti-1407	32	20	.	.	PUNCT
dti-1407	33	1	additionally	additionally	ADV
dti-1407	33	2	,	,	PUNCT
dti-1407	33	3	of	of	ADP
dti-1407	33	4	the	the	DET
dti-1407	33	5	seven	seven	NUM
dti-1407	33	6	anticancer	anticancer	NOUN
dti-1407	33	7	drugs	drug	NOUN
dti-1407	33	8	approved	approve	VERB
dti-1407	33	9	in	in	ADP
dti-1407	33	10	2010	2010	NUM
dti-1407	33	11	,	,	PUNCT
dti-1407	33	12	almost	almost	ADV
dti-1407	33	13	half	half	NOUN
dti-1407	33	14	of	of	ADP
dti-1407	33	15	them	they	PRON
dti-1407	33	16	exert	exert	VERB
dti-1407	33	17	their	their	PRON
dti-1407	33	18	effects	effect	NOUN
dti-1407	33	19	by	by	ADP
dti-1407	33	20	binding	bind	VERB
dti-1407	33	21	onto	onto	ADP
dti-1407	33	22	microtubules.1	microtubules.1	PROPN
dti-1407	33	23	one	one	NUM
dti-1407	33	24	of	of	ADP
dti-1407	33	25	the	the	DET
dti-1407	33	26	biggest	big	ADJ
dti-1407	33	27	success	success	NOUN
dti-1407	33	28	stories	story	NOUN
dti-1407	33	29	of	of	ADP
dti-1407	33	30	microtubule	microtubule	NOUN
dti-1407	33	31	-	-	PUNCT
dti-1407	33	32	targeted	target	VERB
dti-1407	33	33	compounds	compound	NOUN
dti-1407	33	34	from	from	ADP
dti-1407	33	35	a	a	DET
dti-1407	33	36	naturally	naturally	ADV
dti-1407	33	37	derived	derive	VERB
dti-1407	33	38	source	source	NOUN
dti-1407	33	39	is	be	AUX
dti-1407	33	40	paclitaxel	paclitaxel	ADJ
dti-1407	33	41	(	(	PUNCT
dti-1407	33	42	commercially	commercially	ADV
dti-1407	33	43	known	know	VERB
dti-1407	33	44	as	as	ADP
dti-1407	33	45	taxol	taxol	PROPN
dti-1407	33	46	)	)	PUNCT
dti-1407	33	47	,	,	PUNCT
dti-1407	33	48	a	a	DET
dti-1407	33	49	member	member	NOUN
dti-1407	33	50	of	of	ADP
dti-1407	33	51	the	the	DET
dti-1407	33	52	taxane	taxane	NOUN
dti-1407	33	53	family	family	NOUN
dti-1407	33	54	.	.	PUNCT
dti-1407	34	1	paclitaxel	paclitaxel	PROPN
dti-1407	34	2	is	be	AUX
dti-1407	34	3	extracted	extract	VERB
dti-1407	34	4	from	from	ADP
dti-1407	34	5	the	the	DET
dti-1407	34	6	bark	bark	NOUN
dti-1407	34	7	of	of	ADP
dti-1407	34	8	the	the	DET
dti-1407	34	9	pacific	pacific	PROPN
dti-1407	34	10	yew	yew	PROPN
dti-1407	34	11	tree	tree	NOUN
dti-1407	34	12	(	(	PUNCT
dti-1407	34	13	taxus	taxus	NOUN
dti-1407	34	14	brevifolia	brevifolia	NOUN
dti-1407	34	15	)	)	PUNCT
dti-1407	34	16	and	and	CCONJ
dti-1407	34	17	acts	act	VERB
dti-1407	34	18	as	as	ADP
dti-1407	34	19	an	an	DET
dti-1407	34	20	antimitotic	antimitotic	ADJ
dti-1407	34	21	drug	drug	NOUN
dti-1407	34	22	,	,	PUNCT
dti-1407	34	23	by	by	ADP
dti-1407	34	24	binding	bind	VERB
dti-1407	34	25	to	to	ADP
dti-1407	34	26	microtubules	microtubule	NOUN
dti-1407	34	27	,	,	PUNCT
dti-1407	34	28	thus	thus	ADV
dti-1407	34	29	stabilizing	stabilize	VERB
dti-1407	34	30	them	they	PRON
dti-1407	34	31	and	and	CCONJ
dti-1407	34	32	arresting	arrest	VERB
dti-1407	34	33	cells	cell	NOUN
dti-1407	34	34	in	in	ADP
dti-1407	34	35	mitosis.5–9	mitosis.5–9	PROPN
dti-1407	34	36	taxol	taxol	PROPN
dti-1407	34	37	and	and	CCONJ
dti-1407	34	38	its	its	PRON
dti-1407	34	39	derivatives	derivative	NOUN
dti-1407	34	40	have	have	AUX
dti-1407	34	41	successfully	successfully	ADV
dti-1407	34	42	been	be	AUX
dti-1407	34	43	used	use	VERB
dti-1407	34	44	clinically	clinically	ADV
dti-1407	34	45	to	to	PART
dti-1407	34	46	treat	treat	VERB
dti-1407	34	47	ovarian	ovarian	ADJ
dti-1407	34	48	cancer	cancer	NOUN
dti-1407	34	49	,	,	PUNCT
dti-1407	34	50	breast	breast	NOUN
dti-1407	34	51	cancer	cancer	NOUN
dti-1407	34	52	,	,	PUNCT
dti-1407	34	53	and	and	CCONJ
dti-1407	34	54	nonsmall	nonsmall	NOUN
dti-1407	34	55	cell	cell	NOUN
dti-1407	34	56	lung	lung	NOUN
dti-1407	34	57	cancer	cancer	NOUN
dti-1407	34	58	for	for	ADP
dti-1407	34	59	almost	almost	ADV
dti-1407	34	60	40	40	NUM
dti-1407	34	61	years	year	NOUN
dti-1407	34	62	,	,	PUNCT
dti-1407	34	63	making	make	VERB
dti-1407	34	64	taxol	taxol	PROPN
dti-1407	34	65	the	the	DET
dti-1407	34	66	best	well	ADV
dti-1407	34	67	-	-	PUNCT
dti-1407	34	68	selling	sell	VERB
dti-1407	34	69	anticancer	anticancer	NOUN
dti-1407	34	70	drug	drug	NOUN
dti-1407	34	71	currently	currently	ADV
dti-1407	34	72	manufactured	manufacture	VERB
dti-1407	34	73	.	.	PUNCT
dti-1407	35	1	its	its	PRON
dti-1407	35	2	success	success	NOUN
dti-1407	35	3	has	have	AUX
dti-1407	35	4	sparked	spark	VERB
dti-1407	35	5	the	the	DET
dti-1407	35	6	search	search	NOUN
dti-1407	35	7	for	for	ADP
dti-1407	35	8	similar	similar	ADJ
dti-1407	35	9	microtubule	microtubule	NOUN
dti-1407	35	10	-	-	PUNCT
dti-1407	35	11	stabilizing	stabilize	VERB
dti-1407	35	12	compounds	compound	NOUN
dti-1407	35	13	.	.	PUNCT
dti-1407	36	1	another	another	DET
dti-1407	36	2	class	class	NOUN
dti-1407	36	3	of	of	ADP
dti-1407	36	4	microtubule	microtubule	NOUN
dti-1407	36	5	-	-	PUNCT
dti-1407	36	6	targeted	target	VERB
dti-1407	36	7	compounds	compound	NOUN
dti-1407	36	8	from	from	ADP
dti-1407	36	9	a	a	DET
dti-1407	36	10	naturally	naturally	ADV
dti-1407	36	11	derived	derive	VERB
dti-1407	36	12	source	source	NOUN
dti-1407	36	13	is	be	AUX
dti-1407	36	14	the	the	DET
dti-1407	36	15	vinca	vinca	NOUN
dti-1407	36	16	alkaloids	alkaloid	NOUN
dti-1407	36	17	,	,	PUNCT
dti-1407	36	18	vincristine	vincristine	NOUN
dti-1407	36	19	and	and	CCONJ
dti-1407	36	20	vinblastine	vinblastine	NOUN
dti-1407	36	21	,	,	PUNCT
dti-1407	36	22	which	which	PRON
dti-1407	36	23	were	be	AUX
dti-1407	36	24	initially	initially	ADV
dti-1407	36	25	isolated	isolate	VERB
dti-1407	36	26	from	from	ADP
dti-1407	36	27	the	the	DET
dti-1407	36	28	madagascar	madagascar	ADJ
dti-1407	36	29	periwinkle	periwinkle	NOUN
dti-1407	36	30	plant	plant	NOUN
dti-1407	36	31	(	(	PUNCT
dti-1407	36	32	catharanthus	catharanthus	NOUN
dti-1407	36	33	roseus).10	roseus).10	VERB
dti-1407	36	34	the	the	DET
dti-1407	36	35	vinca	vinca	NOUN
dti-1407	36	36	alkaloids	alkaloid	NOUN
dti-1407	36	37	are	be	AUX
dti-1407	36	38	microtubule	microtubule	NOUN
dti-1407	36	39	destabilizers	destabilizer	NOUN
dti-1407	36	40	and	and	CCONJ
dti-1407	36	41	have	have	AUX
dti-1407	36	42	proven	prove	VERB
dti-1407	36	43	to	to	PART
dti-1407	36	44	be	be	AUX
dti-1407	36	45	particularly	particularly	ADV
dti-1407	36	46	effective	effective	ADJ
dti-1407	36	47	against	against	ADP
dti-1407	36	48	hematological	hematological	ADJ
dti-1407	36	49	malignancies,11	malignancies,11	NOUN
dti-1407	36	50	and	and	CCONJ
dti-1407	36	51	their	their	PRON
dti-1407	36	52	success	success	NOUN
dti-1407	36	53	has	have	AUX
dti-1407	36	54	generated	generate	VERB
dti-1407	36	55	several	several	ADJ
dti-1407	36	56	semisynthetic	semisynthetic	ADJ
dti-1407	36	57	derivatives	derivative	NOUN
dti-1407	36	58	.	.	PUNCT
dti-1407	37	1	semisynthetic	semisynthetic	ADJ
dti-1407	37	2	and	and	CCONJ
dti-1407	37	3	synthetic	synthetic	ADJ
dti-1407	37	4	derivatives	derivative	NOUN
dti-1407	37	5	may	may	AUX
dti-1407	37	6	offer	offer	VERB
dti-1407	37	7	advantages	advantage	NOUN
dti-1407	37	8	over	over	ADP
dti-1407	37	9	a	a	DET
dti-1407	37	10	fully	fully	ADV
dti-1407	37	11	natural	natural	ADJ
dti-1407	37	12	source	source	NOUN
dti-1407	37	13	,	,	PUNCT
dti-1407	37	14	as	as	SCONJ
dti-1407	37	15	the	the	DET
dti-1407	37	16	bioactive	bioactive	ADJ
dti-1407	37	17	natural	natural	ADJ
dti-1407	37	18	compound	compound	NOUN
dti-1407	37	19	may	may	AUX
dti-1407	37	20	be	be	AUX
dti-1407	37	21	present	present	ADJ
dti-1407	37	22	only	only	ADV
dti-1407	37	23	in	in	ADP
dti-1407	37	24	trace	trace	NOUN
dti-1407	37	25	amounts	amount	NOUN
dti-1407	37	26	.	.	PUNCT
dti-1407	38	1	natural	natural	ADJ
dti-1407	38	2	compounds	compound	NOUN
dti-1407	38	3	may	may	AUX
dti-1407	38	4	instead	instead	ADV
dti-1407	38	5	act	act	VERB
dti-1407	38	6	as	as	ADP
dti-1407	38	7	lead	lead	NOUN
dti-1407	38	8	compounds	compound	NOUN
dti-1407	38	9	,	,	PUNCT
dti-1407	38	10	where	where	SCONJ
dti-1407	38	11	analogs	analog	NOUN
dti-1407	38	12	with	with	ADP
dti-1407	38	13	higher	high	ADJ
dti-1407	38	14	potencies	potency	NOUN
dti-1407	38	15	and	and	CCONJ
dti-1407	38	16	lower	low	ADJ
dti-1407	38	17	toxicities	toxicity	NOUN
dti-1407	38	18	may	may	AUX
dti-1407	38	19	be	be	AUX
dti-1407	38	20	developed12,13	developed12,13	VERB
dti-1407	38	21	(	(	PUNCT
dti-1407	38	22	table	table	NOUN
dti-1407	38	23	2	2	NUM
dti-1407	38	24	)	)	PUNCT
dti-1407	38	25	.	.	PUNCT
dti-1407	39	1	natural	natural	ADJ
dti-1407	39	2	products	product	NOUN
dti-1407	39	3	are	be	AUX
dti-1407	39	4	ideal	ideal	ADJ
dti-1407	39	5	as	as	ADP
dti-1407	39	6	lead	lead	NOUN
dti-1407	39	7	compounds	compound	NOUN
dti-1407	39	8	as	as	SCONJ
dti-1407	39	9	their	their	PRON
dti-1407	39	10	chemical	chemical	NOUN
dti-1407	39	11	structures	structure	NOUN
dti-1407	39	12	are	be	AUX
dti-1407	39	13	complex	complex	ADJ
dti-1407	39	14	and	and	CCONJ
dti-1407	39	15	diverse	diverse	ADJ
dti-1407	39	16	(	(	PUNCT
dti-1407	39	17	table	table	NOUN
dti-1407	39	18	3	3	NUM
dti-1407	39	19	)	)	PUNCT
dti-1407	39	20	.	.	PUNCT
dti-1407	40	1	the	the	DET
dti-1407	40	2	biggest	big	ADJ
dti-1407	40	3	study	study	NOUN
dti-1407	40	4	looking	look	VERB
dti-1407	40	5	into	into	ADP
dti-1407	40	6	the	the	DET
dti-1407	40	7	isolation	isolation	NOUN
dti-1407	40	8	of	of	ADP
dti-1407	40	9	compounds	compound	NOUN
dti-1407	40	10	with	with	ADP
dti-1407	40	11	clinical	clinical	ADJ
dti-1407	40	12	bioactivity	bioactivity	NOUN
dti-1407	40	13	,	,	PUNCT
dti-1407	40	14	specifically	specifically	ADV
dti-1407	40	15	anticancer	anticancer	NOUN
dti-1407	40	16	activity	activity	NOUN
dti-1407	40	17	,	,	PUNCT
dti-1407	40	18	from	from	ADP
dti-1407	40	19	natural	natural	ADJ
dti-1407	40	20	sources	source	NOUN
dti-1407	40	21	was	be	AUX
dti-1407	40	22	done	do	VERB
dti-1407	40	23	by	by	ADP
dti-1407	40	24	the	the	DET
dti-1407	40	25	national	national	PROPN
dti-1407	40	26	cancer	cancer	PROPN
dti-1407	40	27	institute	institute	PROPN
dti-1407	40	28	(	(	PUNCT
dti-1407	40	29	nci	nci	PROPN
dti-1407	40	30	)	)	PUNCT
dti-1407	40	31	of	of	ADP
dti-1407	40	32	the	the	DET
dti-1407	40	33	national	national	PROPN
dti-1407	40	34	journal	journal	PROPN
dti-1407	40	35	name	name	PROPN
dti-1407	40	36	:	:	PUNCT
dti-1407	40	37	drug	drug	NOUN
dti-1407	40	38	target	target	NOUN
dti-1407	40	39	insights	insight	NOUN
dti-1407	40	40	journal	journal	NOUN
dti-1407	40	41	type	type	NOUN
dti-1407	40	42	:	:	PUNCT
dti-1407	40	43	short	short	ADJ
dti-1407	40	44	review	review	NOUN
dti-1407	40	45	year	year	NOUN
dti-1407	40	46	:	:	PUNCT
dti-1407	40	47	2015	2015	NUM
dti-1407	40	48	volume	volume	NOUN
dti-1407	40	49	:	:	PUNCT
dti-1407	40	50	9	9	NUM
dti-1407	40	51	running	run	VERB
dti-1407	40	52	head	head	NOUN
dti-1407	40	53	verso	verso	ADJ
dti-1407	40	54	:	:	PUNCT
dti-1407	40	55	zulkipli	zulkipli	NUM
dti-1407	40	56	et	et	NOUN
dti-1407	40	57	al	al	PROPN
dti-1407	40	58	running	run	VERB
dti-1407	40	59	head	head	NOUN
dti-1407	40	60	recto	recto	ADJ
dti-1407	40	61	:	:	PUNCT
dti-1407	40	62	medicinal	medicinal	ADJ
dti-1407	40	63	plants	plant	NOUN
dti-1407	40	64	:	:	PUNCT
dti-1407	40	65	a	a	DET
dti-1407	40	66	potential	potential	ADJ
dti-1407	40	67	source	source	NOUN
dti-1407	40	68	of	of	ADP
dti-1407	40	69	compounds	compound	NOUN
dti-1407	40	70	for	for	ADP
dti-1407	40	71	targeting	target	VERB
dti-1407	40	72	cell	cell	NOUN
dti-1407	40	73	division	division	NOUN
dti-1407	40	74	http://www.la-press.com/drug-target-insights-journal-j23	http://www.la-press.com/drug-target-insights-journal-j23	PROPN
dti-1407	41	1	http://www.la-press.com	http://www.la-press.com	X
dti-1407	41	2	http://dx.doi.org/10.4137/dti.s24946	http://dx.doi.org/10.4137/dti.s24946	PROPN
dti-1407	41	3	http://creativecommons.org/licenses/by-nc/3.0/	http://creativecommons.org/licenses/by-nc/3.0/	PROPN
dti-1407	42	1	http://creativecommons.org/licenses/by-nc/3.0/	http://creativecommons.org/licenses/by-nc/3.0/	NOUN
dti-1407	43	1	mailto:yusri.idris@ubd.edu.bn	mailto:yusri.idris@ubd.edu.bn	PROPN
dti-1407	43	2	http://www.la-press.com	http://www.la-press.com	X
dti-1407	44	1	http://www.la-press.com/drug-target-insights-journal-j23	http://www.la-press.com/drug-target-insights-journal-j23	PROPN
dti-1407	44	2	zulkipli	zulkipli	NUM
dti-1407	44	3	et	et	NOUN
dti-1407	44	4	al	al	PROPN
dti-1407	44	5	10	10	NUM
dti-1407	44	6	drug	drug	NOUN
dti-1407	44	7	target	target	NOUN
dti-1407	44	8	insights	insight	NOUN
dti-1407	44	9	2015:9	2015:9	NUM
dti-1407	44	10	ta	ta	X
dti-1407	44	11	bl	bl	PROPN
dti-1407	44	12	e	e	PROPN
dti-1407	44	13	1	1	NUM
dti-1407	44	14	.	.	PUNCT
dti-1407	45	1	s	s	PART
dti-1407	45	2	el	el	PROPN
dti-1407	45	3	ec	ec	PROPN
dti-1407	45	4	te	te	PROPN
dti-1407	45	5	d	d	X
dti-1407	45	6	co	co	ADJ
dti-1407	45	7	m	m	PROPN
dti-1407	45	8	po	po	PROPN
dti-1407	45	9	un	un	PROPN
dti-1407	45	10	ds	ds	PROPN
dti-1407	45	11	o	o	PROPN
dti-1407	45	12	rig	rig	NOUN
dti-1407	45	13	in	in	ADP
dti-1407	45	14	al	al	PROPN
dti-1407	45	15	ly	ly	PROPN
dti-1407	45	16	is	be	AUX
dti-1407	45	17	ol	ol	ADJ
dti-1407	45	18	at	at	ADP
dti-1407	45	19	ed	ed	PROPN
dti-1407	45	20	fr	fr	PROPN
dti-1407	45	21	om	om	PROPN
dti-1407	46	1	n	n	INTJ
dti-1407	46	2	at	at	ADP
dti-1407	46	3	ur	ur	INTJ
dti-1407	46	4	al	al	PROPN
dti-1407	46	5	s	s	PROPN
dti-1407	46	6	ou	ou	ADP
dti-1407	46	7	rc	rc	PROPN
dti-1407	46	8	es	es	X
dti-1407	46	9	th	th	X
dti-1407	46	10	at	at	ADP
dti-1407	46	11	a	a	DET
dti-1407	46	12	ct	ct	NOUN
dti-1407	46	13	o	o	NOUN
dti-1407	46	14	n	n	INTJ
dti-1407	47	1	m	m	VERB
dti-1407	47	2	ic	ic	PROPN
dti-1407	47	3	ro	ro	PROPN
dti-1407	47	4	tu	tu	PROPN
dti-1407	47	5	bu	bu	PROPN
dti-1407	47	6	le	le	PROPN
dti-1407	47	7	s.	s.	PROPN
dti-1407	47	8	b	b	PROPN
dti-1407	47	9	io	io	PROPN
dti-1407	47	10	lo	lo	PROPN
dti-1407	47	11	g	g	PROPN
dti-1407	48	1	ic	ic	PROPN
dti-1407	49	1	a	a	DET
dti-1407	49	2	ll	ll	NOUN
dti-1407	49	3	y	y	PROPN
dti-1407	49	4	a	a	DET
dti-1407	49	5	c	c	NOUN
dti-1407	49	6	ti	ti	NOUN
dti-1407	49	7	ve	ve	NOUN
dti-1407	49	8	c	c	NOUN
dti-1407	49	9	o	o	NOUN
dti-1407	49	10	m	m	INTJ
dti-1407	49	11	po	po	NOUN
dti-1407	49	12	u	u	NOUN
dti-1407	49	13	n	n	PROPN
dti-1407	49	14	d	d	X
dti-1407	49	15	(	(	PUNCT
dti-1407	49	16	s	s	NOUN
dti-1407	49	17	)	)	PUNCT
dti-1407	49	18	a	a	DET
dti-1407	49	19	n	n	NOUN
dti-1407	49	20	d	d	X
dti-1407	49	21	th	th	X
dti-1407	49	22	ei	ei	ADP
dti-1407	49	23	r	r	NOUN
dti-1407	49	24	s	s	PROPN
dti-1407	49	25	tr	tr	NOUN
dti-1407	49	26	u	u	NOUN
dti-1407	49	27	c	c	NOUN
dti-1407	49	28	tu	tu	PROPN
dti-1407	49	29	r	r	PROPN
dti-1407	49	30	e	e	PROPN
dti-1407	49	31	sc	sc	PROPN
dti-1407	49	32	ie	ie	X
dti-1407	49	33	n	n	CCONJ
dti-1407	49	34	ti	ti	NOUN
dti-1407	49	35	fi	fi	NOUN
dti-1407	49	36	c	c	PROPN
dti-1407	49	37	n	n	DET
dti-1407	49	38	a	a	DET
dti-1407	49	39	m	m	NOUN
dti-1407	49	40	e	e	NOUN
dti-1407	49	41	(	(	PUNCT
dti-1407	49	42	s	s	NOUN
dti-1407	49	43	)	)	PUNCT
dti-1407	49	44	o	o	NOUN
dti-1407	49	45	f	f	PROPN
dti-1407	49	46	n	n	CCONJ
dti-1407	49	47	at	at	ADP
dti-1407	49	48	u	u	PROPN
dti-1407	49	49	r	r	NOUN
dti-1407	49	50	a	a	DET
dti-1407	49	51	l	l	NOUN
dti-1407	50	1	so	so	CCONJ
dti-1407	50	2	u	u	NOUN
dti-1407	51	1	r	r	NOUN
dti-1407	51	2	c	c	NOUN
dti-1407	51	3	e	e	NOUN
dti-1407	51	4	m	m	NOUN
dti-1407	51	5	ec	ec	PROPN
dti-1407	51	6	h	h	NOUN
dti-1407	51	7	a	a	DET
dti-1407	51	8	n	n	NOUN
dti-1407	51	9	is	be	AUX
dti-1407	51	10	m	m	VERB
dti-1407	51	11	o	o	NOUN
dti-1407	51	12	f	f	NOUN
dti-1407	51	13	a	a	DET
dti-1407	51	14	c	c	NOUN
dti-1407	51	15	ti	ti	NOUN
dti-1407	51	16	o	o	NOUN
dti-1407	51	17	n	n	CCONJ
dti-1407	51	18	o	o	NOUN
dti-1407	52	1	n	n	INTJ
dti-1407	52	2	m	m	VERB
dti-1407	52	3	ic	ic	NOUN
dti-1407	52	4	r	r	NOUN
dti-1407	52	5	o	o	X
dti-1407	52	6	tu	tu	PROPN
dti-1407	52	7	b	b	PROPN
dti-1407	52	8	u	u	PROPN
dti-1407	52	9	le	le	PROPN
dti-1407	52	10	s	s	PROPN
dti-1407	52	11	st	st	PROPN
dti-1407	53	1	at	at	ADP
dti-1407	53	2	u	u	PROPN
dti-1407	53	3	s	s	VERB
dti-1407	53	4	a	a	DET
dti-1407	53	5	s	s	NOUN
dti-1407	53	6	a	a	DET
dti-1407	53	7	n	n	ADV
dti-1407	53	8	ti	ti	X
dti-1407	53	9	-c	-c	PUNCT
dti-1407	53	10	a	a	DET
dti-1407	53	11	n	n	NOUN
dti-1407	53	12	c	c	NOUN
dti-1407	53	13	er	er	INTJ
dti-1407	53	14	d	d	X
dti-1407	53	15	r	r	NOUN
dti-1407	53	16	u	u	NOUN
dti-1407	53	17	g	g	PROPN
dti-1407	53	18	te	te	PROPN
dti-1407	53	19	st	st	PROPN
dti-1407	54	1	ed	ed	PROPN
dti-1407	54	2	c	c	PROPN
dti-1407	54	3	a	a	DET
dti-1407	54	4	n	n	NOUN
dti-1407	55	1	c	c	NOUN
dti-1407	55	2	er	er	INTJ
dti-1407	55	3	t	t	X
dti-1407	55	4	yp	yp	PROPN
dti-1407	55	5	es	es	ADP
dti-1407	55	6	r	r	NOUN
dti-1407	55	7	ef	ef	NOUN
dti-1407	56	1	er	er	INTJ
dti-1407	56	2	en	en	X
dti-1407	56	3	c	c	PROPN
dti-1407	56	4	es	es	X
dti-1407	56	5	p	p	X
dti-1407	56	6	ac	ac	PROPN
dti-1407	56	7	lit	light	VERB
dti-1407	56	8	ax	ax	NOUN
dti-1407	56	9	el	el	PROPN
dti-1407	57	1	ta	ta	PROPN
dti-1407	57	2	xu	xu	PROPN
dti-1407	57	3	s	s	PROPN
dti-1407	58	1	br	br	NOUN
dti-1407	58	2	ev	ev	INTJ
dti-1407	58	3	ifo	ifo	PROPN
dti-1407	58	4	lia	lia	PROPN
dti-1407	58	5	s	s	PROPN
dti-1407	58	6	ta	ta	ADP
dti-1407	58	7	bi	bi	NOUN
dti-1407	58	8	liz	liz	PROPN
dti-1407	58	9	es	es	PROPN
dti-1407	58	10	m	m	PROPN
dti-1407	58	11	ic	ic	PROPN
dti-1407	58	12	ro	ro	X
dti-1407	58	13	tu	tu	PROPN
dti-1407	58	14	bu	bu	PROPN
dti-1407	58	15	le	le	PROPN
dti-1407	58	16	s	s	PROPN
dti-1407	58	17	in	in	ADP
dti-1407	58	18	c	c	PROPN
dti-1407	58	19	lin	lin	PROPN
dti-1407	58	20	ic	ic	PROPN
dti-1407	58	21	al	al	PROPN
dti-1407	58	22	u	u	PROPN
dti-1407	58	23	se	se	PROPN
dti-1407	58	24	o	o	PROPN
dti-1407	58	25	va	va	PROPN
dti-1407	58	26	ria	ria	PROPN
dti-1407	59	1	n	n	PROPN
dti-1407	59	2	ca	can	AUX
dti-1407	59	3	nc	nc	PROPN
dti-1407	59	4	er	er	INTJ
dti-1407	59	5	,	,	PUNCT
dti-1407	59	6	b	b	X
dti-1407	59	7	re	re	X
dti-1407	59	8	as	as	ADP
dti-1407	59	9	t	t	PROPN
dti-1407	59	10	c	c	PROPN
dti-1407	59	11	an	an	PRON
dti-1407	59	12	ce	ce	PROPN
dti-1407	59	13	r	r	PROPN
dti-1407	59	14	,	,	PUNCT
dti-1407	59	15	no	no	DET
dti-1407	59	16	nsm	nsm	NOUN
dti-1407	59	17	al	al	PROPN
dti-1407	59	18	l	l	PROPN
dti-1407	59	19	c	c	PROPN
dti-1407	59	20	el	el	PROPN
dti-1407	59	21	l	l	PROPN
dti-1407	59	22	l	l	PROPN
dti-1407	60	1	un	un	PROPN
dti-1407	60	2	g	g	PROPN
dti-1407	60	3	ca	ca	PROPN
dti-1407	60	4	nc	nc	PROPN
dti-1407	60	5	er	er	INTJ
dti-1407	60	6	,	,	PUNCT
dti-1407	60	7	a	a	DET
dti-1407	60	8	dv	dv	PROPN
dti-1407	60	9	an	an	PROPN
dti-1407	60	10	ce	ce	PROPN
dti-1407	60	11	d	d	PROPN
dti-1407	60	12	k	k	PROPN
dti-1407	60	13	ap	ap	PROPN
dti-1407	61	1	os	os	INTJ
dti-1407	62	1	i	i	PRON
dti-1407	62	2	sa	sa	PROPN
dti-1407	62	3	rc	rc	PROPN
dti-1407	62	4	om	om	PROPN
dti-1407	62	5	a	a	DET
dti-1407	62	6	47	47	NUM
dti-1407	62	7	,	,	PUNCT
dti-1407	62	8	4	4	NUM
dti-1407	62	9	8	8	NUM
dti-1407	62	10	v	v	NOUN
dti-1407	62	11	in	in	ADP
dti-1407	62	12	bl	bl	PROPN
dti-1407	62	13	as	as	ADP
dti-1407	62	14	tin	tin	NOUN
dti-1407	62	15	e	e	NOUN
dti-1407	62	16	v	v	NOUN
dti-1407	62	17	in	in	ADP
dti-1407	62	18	cr	cr	PROPN
dti-1407	62	19	is	be	AUX
dti-1407	62	20	tin	tin	NOUN
dti-1407	62	21	e	e	X
dti-1407	62	22	c	c	NOUN
dti-1407	62	23	at	at	ADP
dti-1407	62	24	ha	ha	INTJ
dti-1407	62	25	ra	ra	PROPN
dti-1407	62	26	nt	not	PART
dti-1407	62	27	hu	hu	PROPN
dti-1407	62	28	s	s	PART
dti-1407	62	29	ro	ro	PROPN
dti-1407	62	30	se	se	X
dti-1407	62	31	us	us	PROPN
dti-1407	63	1	d	d	AUX
dti-1407	63	2	es	es	X
dti-1407	63	3	ta	ta	X
dti-1407	63	4	bi	bi	NOUN
dti-1407	63	5	liz	liz	PROPN
dti-1407	63	6	es	es	PROPN
dti-1407	63	7	m	m	PROPN
dti-1407	63	8	ic	ic	PROPN
dti-1407	63	9	ro	ro	X
dti-1407	63	10	tu	tu	PROPN
dti-1407	63	11	bu	bu	PROPN
dti-1407	63	12	le	le	PROPN
dti-1407	63	13	s	s	PROPN
dti-1407	63	14	in	in	ADP
dti-1407	63	15	c	c	PROPN
dti-1407	63	16	lin	lin	PROPN
dti-1407	63	17	ic	ic	PROPN
dti-1407	63	18	al	al	PROPN
dti-1407	63	19	u	u	PROPN
dti-1407	63	20	se	se	PROPN
dti-1407	63	21	a	a	PROPN
dti-1407	63	22	cu	cu	PROPN
dti-1407	63	23	te	te	X
dti-1407	63	24	ly	ly	ADP
dti-1407	63	25	m	m	VERB
dti-1407	63	26	ph	ph	ADJ
dti-1407	63	27	ob	ob	X
dti-1407	63	28	la	la	PROPN
dti-1407	63	29	st	st	PROPN
dti-1407	63	30	ic	ic	PROPN
dti-1407	63	31	le	le	PROPN
dti-1407	63	32	uk	uk	PROPN
dti-1407	64	1	ae	ae	PROPN
dti-1407	64	2	m	m	PROPN
dti-1407	64	3	ia	ia	PROPN
dti-1407	64	4	,	,	PUNCT
dti-1407	64	5	b	b	X
dti-1407	64	6	re	re	NOUN
dti-1407	64	7	as	as	ADP
dti-1407	64	8	t	t	PROPN
dti-1407	64	9	ca	can	AUX
dti-1407	64	10	nc	nc	PROPN
dti-1407	64	11	er	er	INTJ
dti-1407	64	12	,	,	PUNCT
dti-1407	64	13	c	c	PROPN
dti-1407	64	14	ho	ho	PROPN
dti-1407	64	15	rio	rio	PROPN
dti-1407	64	16	ca	ca	PROPN
dti-1407	64	17	rc	rc	PROPN
dti-1407	64	18	in	in	ADP
dti-1407	64	19	om	om	PROPN
dti-1407	64	20	a	a	PROPN
dti-1407	64	21	,	,	PUNCT
dti-1407	64	22	h	h	PROPN
dti-1407	64	23	od	od	PROPN
dti-1407	64	24	gk	gk	PROPN
dti-1407	64	25	in	in	ADP
dti-1407	64	26	ly	ly	NUM
dti-1407	64	27	m	m	VERB
dti-1407	64	28	ph	ph	ADJ
dti-1407	64	29	om	om	PROPN
dti-1407	64	30	a	a	PROPN
dti-1407	64	31	,	,	PUNCT
dti-1407	65	1	k	k	PROPN
dti-1407	65	2	ap	ap	PROPN
dti-1407	66	1	os	os	INTJ
dti-1407	67	1	i	i	PRON
dti-1407	67	2	s	s	PROPN
dti-1407	67	3	ar	ar	PROPN
dti-1407	67	4	co	co	NOUN
dti-1407	67	5	m	m	PROPN
dti-1407	67	6	a	a	PRON
dti-1407	67	7	,	,	PUNCT
dti-1407	67	8	m	m	VERB
dti-1407	67	9	yc	yc	NOUN
dti-1407	67	10	os	os	NOUN
dti-1407	67	11	is	be	AUX
dti-1407	67	12	fu	fu	PROPN
dti-1407	67	13	ng	ng	PROPN
dti-1407	67	14	oi	oi	PROPN
dti-1407	67	15	de	de	PROPN
dti-1407	67	16	s	s	PROPN
dti-1407	67	17	,	,	PUNCT
dti-1407	67	18	h	h	PROPN
dti-1407	67	19	od	od	PROPN
dti-1407	67	20	gk	gk	PROPN
dti-1407	67	21	in	in	ADP
dti-1407	67	22	a	a	DET
dti-1407	67	23	nd	nd	NOUN
dti-1407	67	24	n	n	NOUN
dti-1407	67	25	on	on	ADP
dti-1407	67	26	-h	-h	PROPN
dti-1407	67	27	od	od	NUM
dti-1407	67	28	gk	gk	PROPN
dti-1407	67	29	in	in	ADP
dti-1407	67	30	ly	ly	NUM
dti-1407	67	31	m	m	VERB
dti-1407	67	32	ph	ph	ADJ
dti-1407	67	33	om	om	PROPN
dti-1407	67	34	a	a	PROPN
dti-1407	67	35	,	,	PUNCT
dti-1407	67	36	te	te	PROPN
dti-1407	67	37	st	st	PROPN
dti-1407	68	1	ic	ic	PROPN
dti-1407	68	2	ul	ul	PROPN
dti-1407	68	3	ar	ar	PROPN
dti-1407	68	4	c	c	PROPN
dti-1407	68	5	an	an	DET
dti-1407	68	6	ce	ce	PROPN
dti-1407	68	7	r	r	PROPN
dti-1407	68	8	,	,	PUNCT
dti-1407	68	9	ne	ne	VERB
dti-1407	68	10	ur	ur	VERB
dti-1407	68	11	obl	obl	PROPN
dti-1407	68	12	as	as	ADP
dti-1407	68	13	to	to	ADP
dti-1407	68	14	m	m	PROPN
dti-1407	68	15	a	a	PRON
dti-1407	68	16	,	,	PUNCT
dti-1407	68	17	rh	rh	PROPN
dti-1407	68	18	ad	ad	NOUN
dti-1407	68	19	do	do	VERB
dti-1407	68	20	m	m	PRON
dti-1407	68	21	yc	yc	PROPN
dti-1407	68	22	os	os	PROPN
dti-1407	68	23	ar	ar	PROPN
dti-1407	68	24	co	co	PROPN
dti-1407	68	25	m	m	PROPN
dti-1407	68	26	a	a	PROPN
dti-1407	68	27	,	,	PUNCT
dti-1407	68	28	w	w	PROPN
dti-1407	68	29	ilm	ilm	NOUN
dti-1407	68	30	s	s	X
dti-1407	68	31	tu	tu	PROPN
dti-1407	68	32	m	m	PROPN
dti-1407	68	33	ou	ou	ADP
dti-1407	68	34	r	r	PROPN
dti-1407	68	35	,	,	PUNCT
dti-1407	68	36	bl	bl	X
dti-1407	68	37	ad	ad	NOUN
dti-1407	68	38	de	de	X
dti-1407	68	39	r	r	PROPN
dti-1407	68	40	c	c	PROPN
dti-1407	68	41	an	an	DET
dti-1407	68	42	ce	ce	PROPN
dti-1407	68	43	r	r	PROPN
dti-1407	68	44	,	,	PUNCT
dti-1407	68	45	te	te	PROPN
dti-1407	68	46	st	st	PROPN
dti-1407	69	1	ic	ic	PROPN
dti-1407	69	2	ul	ul	PROPN
dti-1407	69	3	ar	ar	PROPN
dti-1407	69	4	c	c	PROPN
dti-1407	69	5	an	an	DET
dti-1407	69	6	ce	ce	PROPN
dti-1407	69	7	r	r	PROPN
dti-1407	69	8	,	,	PUNCT
dti-1407	69	9	br	br	PROPN
dti-1407	69	10	ea	ea	PROPN
dti-1407	69	11	st	st	PROPN
dti-1407	69	12	c	c	PROPN
dti-1407	69	13	an	an	DET
dti-1407	69	14	ce	ce	PROPN
dti-1407	69	15	r	r	PROPN
dti-1407	69	16	,	,	PUNCT
dti-1407	69	17	ch	ch	NOUN
dti-1407	69	18	or	or	CCONJ
dti-1407	69	19	io	io	PROPN
dti-1407	69	20	ca	can	AUX
dti-1407	69	21	rc	rc	PROPN
dti-1407	69	22	in	in	ADP
dti-1407	69	23	om	om	PROPN
dti-1407	69	24	a	a	PROPN
dti-1407	69	25	,	,	PUNCT
dti-1407	69	26	lu	lu	PROPN
dti-1407	69	27	ng	ng	PROPN
dti-1407	69	28	c	c	PROPN
dti-1407	69	29	an	an	PRON
dti-1407	69	30	ce	ce	PROPN
dti-1407	69	31	r	r	PROPN
dti-1407	69	32	,	,	PUNCT
dti-1407	69	33	m	m	VERB
dti-1407	69	34	ul	ul	INTJ
dti-1407	69	35	tip	tip	NOUN
dti-1407	69	36	le	le	PROPN
dti-1407	69	37	m	m	VERB
dti-1407	69	38	ye	ye	INTJ
dti-1407	70	1	lo	lo	NOUN
dti-1407	70	2	m	m	VERB
dti-1407	70	3	a	a	PRON
dti-1407	70	4	,	,	PUNCT
dti-1407	70	5	s	s	PROPN
dti-1407	70	6	of	of	ADP
dti-1407	70	7	t	t	PROPN
dti-1407	70	8	t	t	PROPN
dti-1407	70	9	is	be	AUX
dti-1407	71	1	su	su	PROPN
dti-1407	71	2	e	e	PROPN
dti-1407	71	3	sa	sa	PROPN
dti-1407	71	4	rc	rc	PROPN
dti-1407	71	5	om	om	PROPN
dti-1407	71	6	a	a	PROPN
dti-1407	71	7	,	,	PUNCT
dti-1407	71	8	b	b	PROPN
dti-1407	71	9	ra	ra	PROPN
dti-1407	71	10	in	in	ADP
dti-1407	71	11	tu	tu	PROPN
dti-1407	71	12	m	m	VERB
dti-1407	71	13	ou	ou	NOUN
dti-1407	71	14	rs	rs	NOUN
dti-1407	71	15	.	.	PUNCT
dti-1407	72	1	l	l	PROPN
dti-1407	73	1	eu	eu	PROPN
dti-1407	73	2	ka	ka	PROPN
dti-1407	73	3	em	em	PRON
dti-1407	73	4	ia	ia	PROPN
dti-1407	73	5	,	,	PUNCT
dti-1407	73	6	he	he	PRON
dti-1407	73	7	ad	ad	VERB
dti-1407	73	8	a	a	DET
dti-1407	73	9	nd	nd	NOUN
dti-1407	73	10	n	n	ADV
dti-1407	73	11	ec	ec	PROPN
dti-1407	74	1	k	k	PROPN
dti-1407	74	2	ca	can	AUX
dti-1407	74	3	nc	nc	PROPN
dti-1407	74	4	er	er	PROPN
dti-1407	74	5	s	s	PROPN
dti-1407	74	6	10	10	NUM
dti-1407	74	7	,	,	PUNCT
dti-1407	74	8	1	1	NUM
dti-1407	74	9	1	1	NUM
dti-1407	74	10	,	,	PUNCT
dti-1407	74	11	49	49	NUM
dti-1407	74	12	,	,	PUNCT
dti-1407	74	13	5	5	NUM
dti-1407	74	14	0	0	NUM
dti-1407	74	15	c	c	NOUN
dti-1407	74	16	ol	ol	PROPN
dti-1407	74	17	ch	ch	PROPN
dti-1407	74	18	ic	ic	PROPN
dti-1407	74	19	in	in	ADP
dti-1407	74	20	e	e	PROPN
dti-1407	74	21	c	c	PROPN
dti-1407	74	22	ol	ol	PROPN
dti-1407	75	1	ch	ch	PROPN
dti-1407	75	2	ic	ic	INTJ
dti-1407	75	3	um	um	INTJ
dti-1407	75	4	a	a	DET
dti-1407	75	5	ut	ut	INTJ
dti-1407	75	6	um	um	INTJ
dti-1407	75	7	na	na	NOUN
dti-1407	75	8	le	le	PROPN
dti-1407	75	9	d	d	NOUN
dti-1407	75	10	es	es	X
dti-1407	75	11	ta	ta	X
dti-1407	75	12	bi	bi	NOUN
dti-1407	75	13	liz	liz	PROPN
dti-1407	75	14	es	es	PROPN
dti-1407	75	15	m	m	PROPN
dti-1407	75	16	ic	ic	PROPN
dti-1407	75	17	ro	ro	X
dti-1407	75	18	tu	tu	PROPN
dti-1407	75	19	bu	bu	PROPN
dti-1407	75	20	le	le	PROPN
dti-1407	75	21	s	s	PROPN
dti-1407	75	22	fa	fa	INTJ
dti-1407	76	1	ile	ile	PROPN
dti-1407	76	2	d	d	PROPN
dti-1407	76	3	an	an	DET
dti-1407	76	4	tica	tica	PROPN
dti-1407	76	5	nc	nc	PROPN
dti-1407	76	6	er	er	INTJ
dti-1407	77	1	tr	tr	PROPN
dti-1407	77	2	ia	ia	PROPN
dti-1407	77	3	ls	ls	PROPN
dti-1407	77	4	du	du	PROPN
dti-1407	77	5	e	e	X
dti-1407	77	6	to	to	PART
dti-1407	77	7	to	to	ADP
dti-1407	77	8	xi	xi	PROPN
dti-1407	77	9	ci	ci	PROPN
dti-1407	78	1	ty	ty	INTJ
dti-1407	78	2	;	;	PUNCT
dti-1407	78	3	i	i	PRON
dti-1407	78	4	n	n	PRON
dti-1407	78	5	cl	cl	VERB
dti-1407	78	6	in	in	ADP
dti-1407	78	7	ic	ic	PROPN
dti-1407	78	8	al	al	PROPN
dti-1407	78	9	us	us	PROPN
dti-1407	79	1	e	e	NOUN
dti-1407	79	2	fo	fo	INTJ
dti-1407	79	3	r	r	NOUN
dti-1407	79	4	g	g	PROPN
dti-1407	79	5	ou	ou	ADP
dti-1407	79	6	t	t	PROPN
dti-1407	79	7	t	t	PROPN
dti-1407	80	1	he	he	PRON
dti-1407	80	2	ra	ra	INTJ
dti-1407	81	1	py	py	INTJ
dti-1407	81	2	h	h	PROPN
dti-1407	81	3	ep	ep	PROPN
dti-1407	81	4	at	at	ADP
dti-1407	81	5	oc	oc	PROPN
dti-1407	81	6	el	el	PROPN
dti-1407	81	7	lu	lu	PROPN
dti-1407	81	8	la	la	PROPN
dti-1407	81	9	r	r	PROPN
dti-1407	81	10	c	c	PROPN
dti-1407	81	11	ar	ar	NOUN
dti-1407	81	12	ci	ci	PROPN
dti-1407	82	1	no	no	DET
dti-1407	82	2	m	m	NOUN
dti-1407	82	3	a	a	PRON
dti-1407	82	4	,	,	PUNCT
dti-1407	82	5	m	m	VERB
dti-1407	82	6	ul	ul	INTJ
dti-1407	82	7	tip	tip	NOUN
dti-1407	83	1	le	le	PROPN
dti-1407	83	2	m	m	VERB
dti-1407	83	3	ye	ye	INTJ
dti-1407	83	4	lo	lo	NOUN
dti-1407	83	5	m	m	VERB
dti-1407	83	6	a	a	INTJ
dti-1407	83	7	,	,	PUNCT
dti-1407	83	8	h	h	NOUN
dti-1407	83	9	od	od	PROPN
dti-1407	83	10	gk	gk	PROPN
dti-1407	83	11	in	in	ADV
dti-1407	83	12	’s	’s	ADP
dti-1407	83	13	ly	ly	ADP
dti-1407	83	14	m	m	VERB
dti-1407	83	15	ph	ph	ADJ
dti-1407	83	16	om	om	PROPN
dti-1407	83	17	a	a	PROPN
dti-1407	83	18	,	,	PUNCT
dti-1407	83	19	c	c	PROPN
dti-1407	83	20	hr	hr	NOUN
dti-1407	83	21	on	on	ADP
dti-1407	83	22	ic	ic	NUM
dti-1407	83	23	ly	ly	ADP
dti-1407	83	24	m	m	AUX
dti-1407	83	25	ph	ph	ADJ
dti-1407	83	26	at	at	ADP
dti-1407	83	27	ic	ic	PROPN
dti-1407	83	28	le	le	PROPN
dti-1407	83	29	uk	uk	PROPN
dti-1407	84	1	ae	ae	PROPN
dti-1407	84	2	m	m	PROPN
dti-1407	84	3	ia	ia	PROPN
dti-1407	84	4	,	,	PUNCT
dti-1407	84	5	b	b	X
dti-1407	84	6	re	re	NOUN
dti-1407	84	7	as	as	ADP
dti-1407	84	8	t	t	PROPN
dti-1407	84	9	c	c	PROPN
dti-1407	84	10	an	an	DET
dti-1407	84	11	ce	ce	PROPN
dti-1407	84	12	r	r	PROPN
dti-1407	84	13	,	,	PUNCT
dti-1407	84	14	lu	lu	PROPN
dti-1407	84	15	ng	ng	PROPN
dti-1407	84	16	ca	can	AUX
dti-1407	84	17	nc	nc	PROPN
dti-1407	84	18	er	er	INTJ
dti-1407	84	19	,	,	PUNCT
dti-1407	84	20	c	c	PROPN
dti-1407	84	21	hr	hr	PROPN
dti-1407	84	22	on	on	ADP
dti-1407	84	23	ic	ic	NUM
dti-1407	84	24	ly	ly	ADP
dti-1407	84	25	m	m	VERB
dti-1407	84	26	ph	ph	ADJ
dti-1407	84	27	oc	oc	X
dti-1407	84	28	yt	yt	PROPN
dti-1407	84	29	ic	ic	PROPN
dti-1407	84	30	le	le	PROPN
dti-1407	84	31	uk	uk	PROPN
dti-1407	85	1	ae	ae	PROPN
dti-1407	85	2	m	m	PROPN
dti-1407	85	3	ia	ia	PROPN
dti-1407	85	4	51	51	NUM
dti-1407	85	5	–	–	SYM
dti-1407	85	6	5	5	NUM
dti-1407	85	7	3	3	NUM
dti-1407	85	8	p	p	NOUN
dti-1407	85	9	od	od	NUM
dti-1407	85	10	op	op	NOUN
dti-1407	85	11	hy	hy	NOUN
dti-1407	86	1	llo	llo	INTJ
dti-1407	86	2	to	to	ADP
dti-1407	86	3	xi	xi	PROPN
dti-1407	86	4	n	n	PROPN
dti-1407	87	1	p	p	PROPN
dti-1407	87	2	od	od	PROPN
dti-1407	87	3	op	op	NOUN
dti-1407	87	4	hy	hy	NOUN
dti-1407	87	5	llu	llu	VERB
dti-1407	87	6	m	m	NOUN
dti-1407	87	7	s	s	NOUN
dti-1407	87	8	pp	pp	ADJ
dti-1407	87	9	.	.	PUNCT
dti-1407	88	1	d	d	NOUN
dti-1407	88	2	es	es	X
dti-1407	88	3	ta	ta	X
dti-1407	88	4	bi	bi	NOUN
dti-1407	88	5	liz	liz	PROPN
dti-1407	88	6	es	es	PROPN
dti-1407	88	7	m	m	PROPN
dti-1407	88	8	ic	ic	PROPN
dti-1407	88	9	ro	ro	X
dti-1407	88	10	tu	tu	PROPN
dti-1407	88	11	bu	bu	PROPN
dti-1407	88	12	le	le	PROPN
dti-1407	88	13	s	s	PROPN
dti-1407	88	14	in	in	ADP
dti-1407	88	15	u	u	PROPN
dti-1407	88	16	se	se	INTJ
dti-1407	89	1	fo	fo	INTJ
dti-1407	89	2	r	r	NOUN
dti-1407	89	3	t	t	PROPN
dti-1407	89	4	he	he	PRON
dti-1407	89	5	to	to	ADP
dti-1407	89	6	pi	pi	PROPN
dti-1407	89	7	ca	ca	PROPN
dti-1407	89	8	l	l	PROPN
dti-1407	89	9	t	t	PROPN
dti-1407	89	10	re	re	NOUN
dti-1407	89	11	at	at	ADP
dti-1407	89	12	m	m	PROPN
dti-1407	89	13	en	en	ADP
dti-1407	89	14	t	t	X
dti-1407	89	15	o	o	X
dti-1407	90	1	f	f	PROPN
dti-1407	90	2	e	e	X
dti-1407	90	3	xt	xt	PROPN
dti-1407	91	1	er	er	INTJ
dti-1407	91	2	na	na	ADP
dti-1407	91	3	l	l	NOUN
dti-1407	91	4	g	g	PROPN
dti-1407	91	5	en	en	PROPN
dti-1407	91	6	ita	ita	PROPN
dti-1407	91	7	l	l	PROPN
dti-1407	91	8	w	w	PROPN
dti-1407	91	9	ar	ar	PROPN
dti-1407	91	10	ts	ts	ADP
dti-1407	91	11	n	n	PROPN
dti-1407	91	12	on	on	ADP
dti-1407	91	13	e	e	PROPN
dti-1407	91	14	43	43	NUM
dti-1407	91	15	,	,	PUNCT
dti-1407	91	16	5	5	NUM
dti-1407	91	17	4	4	NUM
dti-1407	91	18	,	,	PUNCT
dti-1407	91	19	55	55	NUM
dti-1407	91	20	c	c	NOUN
dti-1407	91	21	om	om	VERB
dti-1407	91	22	br	br	NOUN
dti-1407	91	23	et	et	NOUN
dti-1407	91	24	as	as	ADP
dti-1407	91	25	ta	ta	ADP
dti-1407	91	26	tin	tin	NOUN
dti-1407	91	27	s	s	X
dti-1407	91	28	c	c	X
dti-1407	91	29	om	om	NOUN
dti-1407	91	30	br	br	INTJ
dti-1407	91	31	et	et	INTJ
dti-1407	91	32	um	um	INTJ
dti-1407	91	33	c	c	X
dti-1407	91	34	af	af	PROPN
dti-1407	91	35	fru	fru	PROPN
dti-1407	92	1	m	m	PROPN
dti-1407	92	2	d	d	NOUN
dti-1407	92	3	es	es	X
dti-1407	92	4	ta	ta	ADP
dti-1407	92	5	bi	bi	NOUN
dti-1407	92	6	liz	liz	PROPN
dti-1407	92	7	es	es	PROPN
dti-1407	92	8	m	m	PROPN
dti-1407	93	1	ic	ic	PROPN
dti-1407	93	2	ro	ro	X
dti-1407	93	3	tu	tu	PROPN
dti-1407	93	4	bu	bu	PROPN
dti-1407	93	5	le	le	PROPN
dti-1407	93	6	s	s	PROPN
dti-1407	93	7	p	p	X
dti-1407	93	8	ha	ha	INTJ
dti-1407	93	9	se	se	PROPN
dti-1407	93	10	i	i	PROPN
dti-1407	93	11	,	,	PUNCT
dti-1407	93	12	ii	ii	PROPN
dti-1407	93	13	c	c	PROPN
dti-1407	93	14	lin	lin	PROPN
dti-1407	93	15	ic	ic	PROPN
dti-1407	93	16	al	al	PROPN
dti-1407	93	17	tr	tr	PROPN
dti-1407	93	18	ia	ia	PROPN
dti-1407	93	19	ls	ls	PROPN
dti-1407	93	20	;	;	PUNCT
dti-1407	93	21	s	s	VERB
dti-1407	93	22	em	em	PROPN
dti-1407	93	23	i	i	PROPN
dti-1407	93	24	-	-	PUNCT
dti-1407	93	25	s	s	X
dti-1407	93	26	yn	yn	X
dti-1407	93	27	th	th	X
dti-1407	93	28	et	et	NOUN
dti-1407	93	29	ic	ic	PROPN
dti-1407	94	1	d	d	X
dti-1407	94	2	er	er	INTJ
dti-1407	94	3	iv	iv	X
dti-1407	94	4	at	at	ADP
dti-1407	94	5	iv	iv	ADP
dti-1407	94	6	e	e	NOUN
dti-1407	94	7	in	in	ADP
dti-1407	94	8	p	p	PROPN
dti-1407	94	9	ha	ha	INTJ
dti-1407	94	10	se	se	PROPN
dti-1407	94	11	ii	ii	PROPN
dti-1407	95	1	i	i	PRON
dti-1407	95	2	c	c	PROPN
dti-1407	95	3	lin	lin	PROPN
dti-1407	95	4	ic	ic	PROPN
dti-1407	95	5	al	al	PROPN
dti-1407	95	6	tr	tr	PROPN
dti-1407	95	7	ia	ia	PROPN
dti-1407	95	8	ls	ls	PROPN
dti-1407	95	9	a	a	DET
dti-1407	95	10	cu	cu	PROPN
dti-1407	95	11	te	te	INTJ
dti-1407	95	12	m	m	VERB
dti-1407	95	13	ye	ye	INTJ
dti-1407	95	14	lo	lo	NOUN
dti-1407	95	15	i	i	PROPN
dti-1407	95	16	d	d	PROPN
dti-1407	95	17	le	le	PROPN
dti-1407	95	18	uk	uk	PROPN
dti-1407	95	19	ae	ae	PROPN
dti-1407	95	20	m	m	PROPN
dti-1407	95	21	ia	ia	PROPN
dti-1407	95	22	,	,	PUNCT
dti-1407	95	23	m	m	VERB
dti-1407	95	24	ye	ye	INTJ
dti-1407	95	25	lo	lo	NOUN
dti-1407	95	26	dy	dy	X
dti-1407	95	27	sp	sp	ADP
dti-1407	95	28	la	la	X
dti-1407	95	29	stic	stic	PROPN
dti-1407	95	30	s	s	PROPN
dti-1407	95	31	yn	yn	PROPN
dti-1407	95	32	dr	dr	PROPN
dti-1407	95	33	om	om	PROPN
dti-1407	95	34	e	e	PROPN
dti-1407	95	35	,	,	PUNCT
dti-1407	95	36	th	th	X
dti-1407	95	37	yr	yr	NOUN
dti-1407	96	1	oi	oi	PROPN
dti-1407	96	2	d	d	PROPN
dti-1407	96	3	ca	can	AUX
dti-1407	96	4	nc	nc	PROPN
dti-1407	96	5	er	er	INTJ
dti-1407	96	6	,	,	PUNCT
dti-1407	96	7	n	n	CCONJ
dti-1407	96	8	on	on	ADP
dti-1407	96	9	-s	-s	PROPN
dti-1407	96	10	m	m	NOUN
dti-1407	96	11	al	al	PROPN
dti-1407	96	12	l	l	PROPN
dti-1407	96	13	ce	ce	PROPN
dti-1407	97	1	ll	ll	AUX
dti-1407	97	2	lu	lu	VERB
dti-1407	97	3	ng	ng	PROPN
dti-1407	97	4	c	c	PROPN
dti-1407	97	5	an	an	PRON
dti-1407	97	6	ce	ce	PROPN
dti-1407	97	7	r	r	PROPN
dti-1407	97	8	,	,	PUNCT
dti-1407	97	9	va	va	PROPN
dti-1407	97	10	rio	rio	PROPN
dti-1407	98	1	us	us	PROPN
dti-1407	98	2	s	s	VERB
dti-1407	98	3	ol	ol	PROPN
dti-1407	98	4	i	i	PROPN
dti-1407	98	5	d	d	PROPN
dti-1407	98	6	tu	tu	PROPN
dti-1407	98	7	m	m	VERB
dti-1407	98	8	ou	ou	NOUN
dti-1407	98	9	rs	rs	NUM
dti-1407	98	10	56	56	NUM
dti-1407	99	1	n	n	CCONJ
dti-1407	99	2	os	os	NOUN
dti-1407	100	1	ca	can	AUX
dti-1407	100	2	pi	pi	PROPN
dti-1407	100	3	ne	ne	PROPN
dti-1407	101	1	p	p	PROPN
dti-1407	101	2	ap	ap	PROPN
dti-1407	102	1	av	av	PROPN
dti-1407	102	2	er	er	INTJ
dti-1407	102	3	ac	ac	PROPN
dti-1407	102	4	ea	ea	PROPN
dti-1407	102	5	e	e	X
dti-1407	102	6	sp	sp	ADP
dti-1407	102	7	p.	p.	NOUN
dti-1407	102	8	s	s	PART
dti-1407	102	9	up	up	ADP
dti-1407	102	10	pr	pr	NOUN
dti-1407	102	11	es	es	X
dti-1407	102	12	se	se	PROPN
dti-1407	102	13	s	s	PART
dti-1407	102	14	m	m	VERB
dti-1407	102	15	ic	ic	PROPN
dti-1407	102	16	ro	ro	X
dti-1407	102	17	tu	tu	PROPN
dti-1407	102	18	bu	bu	PROPN
dti-1407	102	19	le	le	PROPN
dti-1407	102	20	dy	dy	X
dti-1407	102	21	na	na	ADP
dti-1407	102	22	m	m	PROPN
dti-1407	102	23	ic	ic	PROPN
dti-1407	102	24	s	s	PROPN
dti-1407	102	25	p	p	X
dti-1407	102	26	ha	ha	INTJ
dti-1407	102	27	se	se	PROPN
dti-1407	102	28	ii	ii	PROPN
dti-1407	103	1	c	c	PROPN
dti-1407	103	2	lin	lin	PROPN
dti-1407	103	3	ic	ic	PROPN
dti-1407	103	4	al	al	PROPN
dti-1407	103	5	tr	tr	PROPN
dti-1407	103	6	ia	ia	PROPN
dti-1407	103	7	ls	ls	PROPN
dti-1407	103	8	m	m	PROPN
dti-1407	103	9	ul	ul	INTJ
dti-1407	103	10	tip	tip	NOUN
dti-1407	103	11	le	le	INTJ
dti-1407	103	12	m	m	VERB
dti-1407	103	13	ye	ye	INTJ
dti-1407	104	1	lo	lo	NOUN
dti-1407	104	2	m	m	VERB
dti-1407	105	1	a	a	DET
dti-1407	105	2	57	57	NUM
dti-1407	105	3	n	n	NOUN
dti-1407	105	4	ot	ot	NOUN
dti-1407	105	5	e	e	NOUN
dti-1407	105	6	:	:	PUNCT
dti-1407	105	7	d	d	X
dti-1407	105	8	at	at	ADP
dti-1407	105	9	a	a	PRON
dti-1407	105	10	in	in	ADP
dti-1407	105	11	th	th	X
dti-1407	105	12	is	be	AUX
dti-1407	105	13	ta	ta	ADP
dti-1407	105	14	bl	bl	PROPN
dti-1407	105	15	e	e	PROPN
dti-1407	105	16	w	w	PROPN
dti-1407	105	17	er	er	INTJ
dti-1407	105	18	e	e	X
dti-1407	105	19	ob	ob	X
dti-1407	105	20	ta	ta	PROPN
dti-1407	105	21	in	in	ADP
dti-1407	105	22	ed	ed	PROPN
dti-1407	105	23	fr	fr	INTJ
dti-1407	105	24	om	om	PROPN
dti-1407	106	1	a	a	DET
dti-1407	106	2	c	c	NOUN
dti-1407	106	3	om	om	PROPN
dti-1407	106	4	bi	bi	NOUN
dti-1407	106	5	na	na	AUX
dti-1407	106	6	tio	tio	PROPN
dti-1407	106	7	n	n	PROPN
dti-1407	106	8	of	of	ADP
dti-1407	106	9	n	n	PRON
dti-1407	106	10	c	c	NOUN
dti-1407	107	1	i	i	NOUN
dti-1407	108	1	d	d	NOUN
dti-1407	108	2	ru	ru	PROPN
dti-1407	108	3	g	g	PROPN
dti-1407	108	4	d	d	PROPN
dti-1407	108	5	ic	ic	PROPN
dti-1407	108	6	tio	tio	NOUN
dti-1407	108	7	na	na	INTJ
dti-1407	108	8	ry	ry	PROPN
dti-1407	108	9	(	(	PUNCT
dti-1407	108	10	h	h	NOUN
dti-1407	108	11	ttp	ttp	PROPN
dti-1407	109	1	:	:	PUNCT
dti-1407	109	2	//	//	PROPN
dti-1407	109	3	w	w	PROPN
dti-1407	109	4	w	w	PROPN
dti-1407	109	5	w	w	PROPN
dti-1407	109	6	.c	.c	PROPN
dti-1407	109	7	an	an	DET
dti-1407	109	8	ce	ce	PROPN
dti-1407	109	9	r.g	r.g	PROPN
dti-1407	109	10	ov	ov	INTJ
dti-1407	109	11	/d	/d	PUNCT
dti-1407	110	1	ru	ru	AUX
dti-1407	110	2	gd	gd	INTJ
dti-1407	110	3	ic	ic	PROPN
dti-1407	110	4	tio	tio	NOUN
dti-1407	110	5	na	na	X
dti-1407	110	6	ry	ry	PROPN
dti-1407	110	7	)	)	PUNCT
dti-1407	110	8	,	,	PUNCT
dti-1407	110	9	pu	pu	PROPN
dti-1407	110	10	bl	bl	PROPN
dti-1407	110	11	is	be	AUX
dti-1407	110	12	he	he	PRON
dti-1407	110	13	d	d	NOUN
dti-1407	110	14	lit	light	VERB
dti-1407	110	15	er	er	INTJ
dti-1407	110	16	at	at	ADP
dti-1407	110	17	ur	ur	PROPN
dti-1407	110	18	e	e	NOUN
dti-1407	110	19	,	,	PUNCT
dti-1407	111	1	a	a	DET
dti-1407	111	2	nd	nd	NOUN
dti-1407	111	3	c	c	NOUN
dti-1407	111	4	om	om	PROPN
dti-1407	111	5	pa	pa	PROPN
dti-1407	111	6	ny	ny	PROPN
dti-1407	111	7	w	w	PROPN
dti-1407	111	8	eb	eb	PROPN
dti-1407	111	9	s	s	PROPN
dti-1407	112	1	ite	ite	PROPN
dti-1407	112	2	s.	s.	PROPN
dti-1407	112	3	http://www.la-press.com	http://www.la-press.com	X
dti-1407	113	1	http://www.la-press.com/drug-target-insights-journal-j23	http://www.la-press.com/drug-target-insights-journal-j23	PROPN
dti-1407	113	2	11drug	11drug	PROPN
dti-1407	113	3	target	target	NOUN
dti-1407	113	4	insights	insight	VERB
dti-1407	113	5	2015:9	2015:9	PRON
dti-1407	113	6	medicinal	medicinal	ADJ
dti-1407	113	7	plants	plant	NOUN
dti-1407	113	8	:	:	PUNCT
dti-1407	113	9	a	a	DET
dti-1407	113	10	potential	potential	ADJ
dti-1407	113	11	source	source	NOUN
dti-1407	113	12	of	of	ADP
dti-1407	113	13	compounds	compound	NOUN
dti-1407	113	14	for	for	ADP
dti-1407	113	15	targeting	target	VERB
dti-1407	113	16	cell	cell	NOUN
dti-1407	113	17	division	division	NOUN
dti-1407	113	18	table	table	NOUN
dti-1407	113	19	2	2	NUM
dti-1407	113	20	.	.	PUNCT
dti-1407	113	21	selected	select	VERB
dti-1407	113	22	synthetic	synthetic	ADJ
dti-1407	113	23	and	and	CCONJ
dti-1407	113	24	semisynthetic	semisynthetic	ADJ
dti-1407	113	25	compounds	compound	NOUN
dti-1407	113	26	originally	originally	ADV
dti-1407	113	27	isolated	isolate	VERB
dti-1407	113	28	from	from	ADP
dti-1407	113	29	natural	natural	ADJ
dti-1407	113	30	sources	source	NOUN
dti-1407	113	31	that	that	PRON
dti-1407	113	32	act	act	VERB
dti-1407	113	33	on	on	ADP
dti-1407	113	34	microtubules	microtubule	NOUN
dti-1407	113	35	.	.	PUNCT
dti-1407	114	1	compound	compound	NOUN
dti-1407	114	2	and	and	CCONJ
dti-1407	114	3	structure	structure	NOUN
dti-1407	114	4	original	original	ADJ
dti-1407	114	5	compound	compound	NOUN
dti-1407	114	6	mechanism	mechanism	NOUN
dti-1407	114	7	of	of	ADP
dti-1407	114	8	action	action	NOUN
dti-1407	114	9	on	on	ADP
dti-1407	114	10	microtubules	microtubule	NOUN
dti-1407	114	11	status	status	NOUN
dti-1407	114	12	as	as	SCONJ
dti-1407	114	13	anticancer	anticancer	NOUN
dti-1407	114	14	drug	drug	NOUN
dti-1407	114	15	tested	test	VERB
dti-1407	114	16	cancer	cancer	NOUN
dti-1407	114	17	types	type	NOUN
dti-1407	114	18	references	reference	NOUN
dti-1407	114	19	vindesine	vindesine	NOUN
dti-1407	114	20	vinca	vinca	NOUN
dti-1407	114	21	alkaloids	alkaloid	NOUN
dti-1407	114	22	destabilizes	destabilize	VERB
dti-1407	114	23	microtubules	microtubule	NOUN
dti-1407	114	24	in	in	ADP
dti-1407	114	25	clinical	clinical	ADJ
dti-1407	114	26	use	use	NOUN
dti-1407	114	27	various	various	ADJ
dti-1407	114	28	lung	lung	NOUN
dti-1407	114	29	cancers	cancer	NOUN
dti-1407	114	30	,	,	PUNCT
dti-1407	114	31	various	various	ADJ
dti-1407	114	32	haematological	haematological	ADJ
dti-1407	114	33	malignancies	malignancy	NOUN
dti-1407	114	34	,	,	PUNCT
dti-1407	114	35	melanoma	melanoma	NOUN
dti-1407	114	36	,	,	PUNCT
dti-1407	114	37	renal	renal	ADJ
dti-1407	114	38	cancer	cancer	NOUN
dti-1407	114	39	,	,	PUNCT
dti-1407	114	40	colorectal	colorectal	ADJ
dti-1407	114	41	cancer	cancer	NOUN
dti-1407	114	42	and	and	CCONJ
dti-1407	114	43	breast	breast	NOUN
dti-1407	114	44	cancer	cancer	NOUN
dti-1407	114	45	.	.	PUNCT
dti-1407	115	1	currently	currently	ADV
dti-1407	115	2	in	in	ADP
dti-1407	115	3	clinical	clinical	ADJ
dti-1407	115	4	trials	trial	NOUN
dti-1407	115	5	for	for	ADP
dti-1407	115	6	other	other	ADJ
dti-1407	115	7	cancer	cancer	NOUN
dti-1407	115	8	types	type	NOUN
dti-1407	115	9	58	58	NUM
dti-1407	115	10	vinorelbine	vinorelbine	NOUN
dti-1407	115	11	vinca	vinca	NOUN
dti-1407	115	12	alkaloids	alkaloid	NOUN
dti-1407	115	13	destabilizes	destabilize	VERB
dti-1407	115	14	microtubules	microtubule	NOUN
dti-1407	115	15	in	in	ADP
dti-1407	115	16	clinical	clinical	ADJ
dti-1407	115	17	use	use	NOUN
dti-1407	115	18	non	non	ADJ
dti-1407	115	19	-	-	ADJ
dti-1407	115	20	small	small	ADJ
dti-1407	115	21	cell	cell	NOUN
dti-1407	115	22	lung	lung	NOUN
dti-1407	115	23	cancer	cancer	NOUN
dti-1407	115	24	,	,	PUNCT
dti-1407	115	25	metastatic	metastatic	ADJ
dti-1407	115	26	breast	breast	NOUN
dti-1407	115	27	cancer	cancer	NOUN
dti-1407	115	28	,	,	PUNCT
dti-1407	115	29	renal	renal	ADJ
dti-1407	115	30	cancer	cancer	NOUN
dti-1407	115	31	42,59,60	42,59,60	NUM
dti-1407	115	32	vinflunine	vinflunine	NOUN
dti-1407	115	33	vinca	vinca	NOUN
dti-1407	115	34	alkaloids	alkaloid	NOUN
dti-1407	115	35	destabilizes	destabilize	VERB
dti-1407	115	36	microtubules	microtubule	NOUN
dti-1407	115	37	in	in	ADP
dti-1407	115	38	clinical	clinical	ADJ
dti-1407	115	39	use	use	NOUN
dti-1407	115	40	bladder	bladder	NOUN
dti-1407	115	41	cancer	cancer	NOUN
dti-1407	115	42	,	,	PUNCT
dti-1407	115	43	urethral	urethral	ADJ
dti-1407	115	44	cancer	cancer	NOUN
dti-1407	115	45	,	,	PUNCT
dti-1407	115	46	ureteral	ureteral	ADJ
dti-1407	115	47	cancer	cancer	NOUN
dti-1407	115	48	,	,	PUNCT
dti-1407	115	49	cancer	cancer	NOUN
dti-1407	115	50	of	of	ADP
dti-1407	115	51	the	the	DET
dti-1407	115	52	renal	renal	ADJ
dti-1407	115	53	pelvis	pelvi	VERB
dti-1407	115	54	42	42	NUM
dti-1407	115	55	docetaxel	docetaxel	NOUN
dti-1407	115	56	paclitaxel	paclitaxel	NOUN
dti-1407	115	57	stabilizes	stabilize	VERB
dti-1407	115	58	microtubules	microtubule	NOUN
dti-1407	115	59	in	in	ADP
dti-1407	115	60	clinical	clinical	ADJ
dti-1407	115	61	use	use	NOUN
dti-1407	115	62	breast	breast	NOUN
dti-1407	115	63	cancer	cancer	NOUN
dti-1407	115	64	,	,	PUNCT
dti-1407	115	65	gastric	gastric	ADJ
dti-1407	115	66	cancer	cancer	NOUN
dti-1407	115	67	,	,	PUNCT
dti-1407	115	68	nonsmall	nonsmall	NOUN
dti-1407	115	69	cell	cell	NOUN
dti-1407	115	70	lung	lung	NOUN
dti-1407	115	71	cancer	cancer	NOUN
dti-1407	115	72	,	,	PUNCT
dti-1407	115	73	prostrate	prostrate	NOUN
dti-1407	115	74	cancer	cancer	NOUN
dti-1407	115	75	,	,	PUNCT
dti-1407	115	76	squamous	squamous	ADJ
dti-1407	115	77	cell	cell	NOUN
dti-1407	115	78	carcinoma	carcinoma	NOUN
dti-1407	115	79	of	of	ADP
dti-1407	115	80	the	the	DET
dti-1407	115	81	head	head	NOUN
dti-1407	115	82	and	and	CCONJ
dti-1407	115	83	neck	neck	NOUN
dti-1407	115	84	,	,	PUNCT
dti-1407	115	85	stomach	stomach	NOUN
dti-1407	115	86	cancer	cancer	NOUN
dti-1407	115	87	61	61	NUM
dti-1407	115	88	cabazitaxel	cabazitaxel	PROPN
dti-1407	115	89	paclitaxel	paclitaxel	PROPN
dti-1407	115	90	stabilizes	stabilize	VERB
dti-1407	115	91	microtubules	microtubule	NOUN
dti-1407	115	92	in	in	ADP
dti-1407	115	93	clinical	clinical	ADJ
dti-1407	115	94	use	use	NOUN
dti-1407	115	95	metastatic	metastatic	ADJ
dti-1407	115	96	prostrate	prostrate	NOUN
dti-1407	115	97	cancer	cancer	NOUN
dti-1407	115	98	62,63	62,63	NOUN
dti-1407	115	99	larotaxel	larotaxel	VERB
dti-1407	115	100	paclitaxel	paclitaxel	NOUN
dti-1407	115	101	stabilizes	stabilize	VERB
dti-1407	115	102	microtubules	microtubule	NOUN
dti-1407	115	103	phase	phase	NOUN
dti-1407	115	104	iii	iii	NUM
dti-1407	115	105	clinical	clinical	ADJ
dti-1407	115	106	trials	trial	NOUN
dti-1407	115	107	breast	breast	NOUN
dti-1407	115	108	cancer	cancer	NOUN
dti-1407	115	109	,	,	PUNCT
dti-1407	115	110	pancreatic	pancreatic	ADJ
dti-1407	115	111	cancer	cancer	NOUN
dti-1407	115	112	,	,	PUNCT
dti-1407	115	113	urothelial	urothelial	ADJ
dti-1407	115	114	tract	tract	NOUN
dti-1407	115	115	cancer	cancer	NOUN
dti-1407	115	116	,	,	PUNCT
dti-1407	115	117	bladder	bladder	NOUN
dti-1407	115	118	cancer	cancer	NOUN
dti-1407	115	119	,	,	PUNCT
dti-1407	115	120	various	various	ADJ
dti-1407	115	121	solid	solid	ADJ
dti-1407	115	122	tumours	tumour	NOUN
dti-1407	115	123	63	63	NUM
dti-1407	115	124	tesetaxel	tesetaxel	NOUN
dti-1407	115	125	paclitaxel	paclitaxel	NOUN
dti-1407	115	126	stabilizes	stabilize	VERB
dti-1407	115	127	microtubules	microtubule	NOUN
dti-1407	115	128	phase	phase	NOUN
dti-1407	115	129	ii	ii	NOUN
dti-1407	115	130	clinical	clinical	ADJ
dti-1407	115	131	trials	trial	NOUN
dti-1407	115	132	gastric	gastric	ADJ
dti-1407	115	133	cancer	cancer	NOUN
dti-1407	115	134	,	,	PUNCT
dti-1407	115	135	melanoma	melanoma	NOUN
dti-1407	115	136	,	,	PUNCT
dti-1407	115	137	bladder	bladder	NOUN
dti-1407	115	138	cancer	cancer	NOUN
dti-1407	115	139	,	,	PUNCT
dti-1407	115	140	breast	breast	NOUN
dti-1407	115	141	cancer	cancer	NOUN
dti-1407	115	142	,	,	PUNCT
dti-1407	115	143	prostate	prostate	NOUN
dti-1407	115	144	cancer	cancer	NOUN
dti-1407	115	145	,	,	PUNCT
dti-1407	115	146	various	various	ADJ
dti-1407	115	147	solid	solid	ADJ
dti-1407	115	148	tumours	tumour	NOUN
dti-1407	115	149	63	63	NUM
dti-1407	115	150	ombrabulin	ombrabulin	PROPN
dti-1407	115	151	combrestatin	combrestatin	PROPN
dti-1407	115	152	destabilizes	destabilize	VERB
dti-1407	115	153	microtubules	microtubule	NOUN
dti-1407	115	154	discontinued	discontinue	VERB
dti-1407	115	155	,	,	PUNCT
dti-1407	115	156	due	due	ADP
dti-1407	115	157	to	to	ADP
dti-1407	115	158	insufficient	insufficient	ADJ
dti-1407	115	159	clinical	clinical	ADJ
dti-1407	115	160	benefit	benefit	NOUN
dti-1407	115	161	soft	soft	ADJ
dti-1407	115	162	tissue	tissue	NOUN
dti-1407	115	163	sarcoma	sarcoma	NOUN
dti-1407	115	164	,	,	PUNCT
dti-1407	115	165	non	non	ADJ
dti-1407	115	166	-	-	ADJ
dti-1407	115	167	small	small	ADJ
dti-1407	115	168	cell	cell	NOUN
dti-1407	115	169	lung	lung	NOUN
dti-1407	115	170	cancer	cancer	NOUN
dti-1407	115	171	,	,	PUNCT
dti-1407	115	172	ovarian	ovarian	ADJ
dti-1407	115	173	cancer	cancer	NOUN
dti-1407	115	174	,	,	PUNCT
dti-1407	115	175	various	various	ADJ
dti-1407	115	176	solid	solid	ADJ
dti-1407	115	177	tumours	tumour	NOUN
dti-1407	115	178	55,64	55,64	NUM
dti-1407	115	179	fosbretabulin	fosbretabulin	NOUN
dti-1407	115	180	combrestatin	combrestatin	PROPN
dti-1407	115	181	destabilizes	destabilize	VERB
dti-1407	115	182	microtubules	microtubule	NOUN
dti-1407	115	183	phase	phase	NOUN
dti-1407	116	1	i	i	PRON
dti-1407	116	2	and	and	CCONJ
dti-1407	116	3	phase	phase	NOUN
dti-1407	116	4	ii	ii	NOUN
dti-1407	116	5	clinical	clinical	ADJ
dti-1407	116	6	trials	trial	NOUN
dti-1407	116	7	ovarian	ovarian	ADJ
dti-1407	116	8	cancer	cancer	NOUN
dti-1407	116	9	,	,	PUNCT
dti-1407	116	10	gastrointestinal	gastrointestinal	ADJ
dti-1407	116	11	neuroendocrine	neuroendocrine	NOUN
dti-1407	116	12	tumours	tumour	NOUN
dti-1407	116	13	,	,	PUNCT
dti-1407	116	14	ovarian	ovarian	ADJ
dti-1407	116	15	epithelial	epithelial	ADJ
dti-1407	116	16	,	,	PUNCT
dti-1407	116	17	fallopian	fallopian	ADJ
dti-1407	116	18	tube	tube	NOUN
dti-1407	116	19	,	,	PUNCT
dti-1407	116	20	and	and	CCONJ
dti-1407	116	21	primary	primary	ADJ
dti-1407	116	22	peritoneal	peritoneal	ADJ
dti-1407	116	23	cancers	cancer	NOUN
dti-1407	116	24	,	,	PUNCT
dti-1407	116	25	gliomas	glioma	NOUN
dti-1407	116	26	,	,	PUNCT
dti-1407	116	27	thyroid	thyroid	NOUN
dti-1407	116	28	cancer	cancer	NOUN
dti-1407	116	29	65	65	NUM
dti-1407	116	30	crolibulin	crolibulin	PROPN
dti-1407	116	31	combrestatin	combrestatin	PROPN
dti-1407	116	32	destabilizes	destabilize	VERB
dti-1407	116	33	microtubules	microtubule	NOUN
dti-1407	116	34	phase	phase	NOUN
dti-1407	116	35	i	i	PRON
dti-1407	116	36	and	and	CCONJ
dti-1407	116	37	phase	phase	NOUN
dti-1407	116	38	ii	ii	PROPN
dti-1407	116	39	clinical	clinical	ADJ
dti-1407	116	40	trials	trial	NOUN
dti-1407	116	41	thyroid	thyroid	VERB
dti-1407	116	42	cancer	cancer	NOUN
dti-1407	116	43	66	66	NUM
dti-1407	116	44	verubulin	verubulin	NOUN
dti-1407	116	45	combrestatin	combrestatin	PROPN
dti-1407	116	46	destabilizes	destabilize	VERB
dti-1407	116	47	microtubules	microtubule	NOUN
dti-1407	116	48	phase	phase	NOUN
dti-1407	116	49	i	i	PRON
dti-1407	116	50	and	and	CCONJ
dti-1407	116	51	phase	phase	NOUN
dti-1407	116	52	ii	ii	NOUN
dti-1407	116	53	clinical	clinical	ADJ
dti-1407	116	54	trials	trial	NOUN
dti-1407	116	55	glioblastoma	glioblastoma	NOUN
dti-1407	116	56	66–68	66–68	NUM
dti-1407	116	57	note	note	NOUN
dti-1407	116	58	:	:	PUNCT
dti-1407	116	59	data	datum	NOUN
dti-1407	116	60	in	in	ADP
dti-1407	116	61	this	this	DET
dti-1407	116	62	table	table	NOUN
dti-1407	116	63	were	be	AUX
dti-1407	116	64	obtained	obtain	VERB
dti-1407	116	65	from	from	ADP
dti-1407	116	66	a	a	DET
dti-1407	116	67	combination	combination	NOUN
dti-1407	116	68	of	of	ADP
dti-1407	116	69	nci	nci	PROPN
dti-1407	116	70	drug	drug	PROPN
dti-1407	116	71	dictionary	dictionary	PROPN
dti-1407	116	72	(	(	PUNCT
dti-1407	116	73	http://www.cancer.gov/drugdictionary	http://www.cancer.gov/drugdictionary	PROPN
dti-1407	116	74	)	)	PUNCT
dti-1407	116	75	,	,	PUNCT
dti-1407	116	76	published	publish	VERB
dti-1407	116	77	literature	literature	NOUN
dti-1407	116	78	,	,	PUNCT
dti-1407	116	79	and	and	CCONJ
dti-1407	116	80	company	company	NOUN
dti-1407	116	81	web	web	NOUN
dti-1407	116	82	sites	site	NOUN
dti-1407	116	83	.	.	PUNCT
dti-1407	117	1	institute	institute	PROPN
dti-1407	117	2	of	of	ADP
dti-1407	117	3	health	health	PROPN
dti-1407	117	4	in	in	ADP
dti-1407	117	5	usa	usa	PROPN
dti-1407	117	6	from	from	ADP
dti-1407	117	7	1960	1960	NUM
dti-1407	117	8	to	to	ADP
dti-1407	117	9	1980.14	1980.14	NUM
dti-1407	117	10	however	however	ADV
dti-1407	117	11	,	,	PUNCT
dti-1407	117	12	it	it	PRON
dti-1407	117	13	is	be	AUX
dti-1407	117	14	estimated	estimate	VERB
dti-1407	117	15	that	that	SCONJ
dti-1407	117	16	.90	.90	NUM
dti-1407	117	17	%	%	NOUN
dti-1407	117	18	of	of	ADP
dti-1407	117	19	plant	plant	NOUN
dti-1407	117	20	species	specie	NOUN
dti-1407	117	21	worldwide	worldwide	ADV
dti-1407	117	22	remain	remain	VERB
dti-1407	117	23	understudied	understudied	ADJ
dti-1407	117	24	.	.	PUNCT
dti-1407	118	1	discovery	discovery	NOUN
dti-1407	118	2	of	of	ADP
dti-1407	118	3	drug	drug	NOUN
dti-1407	118	4	molecules	molecule	NOUN
dti-1407	118	5	has	have	AUX
dti-1407	118	6	been	be	AUX
dti-1407	118	7	limited	limit	VERB
dti-1407	118	8	because	because	SCONJ
dti-1407	118	9	of	of	ADP
dti-1407	118	10	genomic	genomic	NOUN
dti-1407	118	11	instability	instability	NOUN
dti-1407	118	12	and	and	CCONJ
dti-1407	118	13	drug	drug	NOUN
dti-1407	118	14	resistance	resistance	NOUN
dti-1407	118	15	characteristics	characteristic	NOUN
dti-1407	118	16	in	in	ADP
dti-1407	118	17	certain	certain	ADJ
dti-1407	118	18	cancer	cancer	NOUN
dti-1407	118	19	cells.15	cells.15	NOUN
dti-1407	118	20	therefore	therefore	ADV
dti-1407	118	21	,	,	PUNCT
dti-1407	118	22	modern	modern	ADJ
dti-1407	118	23	drug	drug	NOUN
dti-1407	118	24	discovery	discovery	NOUN
dti-1407	118	25	has	have	AUX
dti-1407	118	26	shifted	shift	VERB
dti-1407	118	27	to	to	ADP
dti-1407	118	28	personalized	personalized	ADJ
dti-1407	118	29	treatment	treatment	NOUN
dti-1407	118	30	of	of	ADP
dti-1407	118	31	patients	patient	NOUN
dti-1407	118	32	,	,	PUNCT
dti-1407	118	33	where	where	SCONJ
dti-1407	118	34	drugs	drug	NOUN
dti-1407	118	35	are	be	AUX
dti-1407	118	36	selected	select	VERB
dti-1407	118	37	for	for	ADP
dti-1407	118	38	specific	specific	ADJ
dti-1407	118	39	molecular	molecular	ADJ
dti-1407	118	40	targets	target	NOUN
dti-1407	118	41	,	,	PUNCT
dti-1407	118	42	taking	take	VERB
dti-1407	118	43	advantage	advantage	NOUN
dti-1407	118	44	of	of	ADP
dti-1407	118	45	the	the	DET
dti-1407	118	46	vulnerabilities	vulnerability	NOUN
dti-1407	118	47	of	of	ADP
dti-1407	118	48	cancer	cancer	NOUN
dti-1407	118	49	in	in	ADP
dti-1407	118	50	a	a	DET
dti-1407	118	51	particular	particular	ADJ
dti-1407	118	52	patient	patient	NOUN
dti-1407	118	53	,	,	PUNCT
dti-1407	118	54	leading	lead	VERB
dti-1407	118	55	to	to	ADP
dti-1407	118	56	increased	increase	VERB
dti-1407	118	57	interest	interest	NOUN
dti-1407	118	58	in	in	ADP
dti-1407	118	59	studying	study	VERB
dti-1407	118	60	traditional	traditional	ADJ
dti-1407	118	61	herbs	herb	NOUN
dti-1407	118	62	as	as	ADP
dti-1407	118	63	an	an	DET
dti-1407	118	64	alternative	alternative	ADJ
dti-1407	118	65	source	source	NOUN
dti-1407	118	66	of	of	ADP
dti-1407	118	67	anticancer	anticancer	NOUN
dti-1407	118	68	drugs	drug	NOUN
dti-1407	118	69	because	because	SCONJ
dti-1407	118	70	of	of	ADP
dti-1407	118	71	its	its	PRON
dti-1407	118	72	multitargeted	multitargete	VERB
dti-1407	118	73	characteristic.16	characteristic.16	NOUN
dti-1407	118	74	the	the	DET
dti-1407	118	75	role	role	NOUN
dti-1407	118	76	of	of	ADP
dti-1407	118	77	the	the	DET
dti-1407	118	78	microtubule	microtubule	NOUN
dti-1407	118	79	in	in	ADP
dti-1407	118	80	cell	cell	NOUN
dti-1407	118	81	division	division	NOUN
dti-1407	118	82	microtubules	microtubule	NOUN
dti-1407	118	83	are	be	AUX
dti-1407	118	84	a	a	DET
dti-1407	118	85	class	class	NOUN
dti-1407	118	86	of	of	ADP
dti-1407	118	87	the	the	DET
dti-1407	118	88	cytoskeletal	cytoskeletal	ADJ
dti-1407	118	89	proteins	protein	NOUN
dti-1407	118	90	present	present	ADJ
dti-1407	118	91	in	in	ADP
dti-1407	118	92	all	all	DET
dti-1407	118	93	eukaryotic	eukaryotic	ADJ
dti-1407	118	94	cells	cell	NOUN
dti-1407	118	95	.	.	PUNCT
dti-1407	119	1	they	they	PRON
dti-1407	119	2	form	form	VERB
dti-1407	119	3	long	long	ADJ
dti-1407	119	4	,	,	PUNCT
dti-1407	119	5	filamentous	filamentous	ADJ
dti-1407	119	6	,	,	PUNCT
dti-1407	119	7	polymeric	polymeric	ADJ
dti-1407	119	8	structures	structure	NOUN
dti-1407	119	9	within	within	ADP
dti-1407	119	10	the	the	DET
dti-1407	119	11	cell	cell	NOUN
dti-1407	119	12	,	,	PUNCT
dti-1407	119	13	composed	compose	VERB
dti-1407	119	14	of	of	ADP
dti-1407	119	15	αand	αand	ADV
dti-1407	119	16	β	β	NOUN
dti-1407	119	17	-	-	PUNCT
dti-1407	119	18	tubulin	tubulin	NOUN
dti-1407	119	19	heterodimers	heterodimer	NOUN
dti-1407	119	20	,	,	PUNCT
dti-1407	119	21	of	of	ADP
dti-1407	119	22	which	which	PRON
dti-1407	119	23	there	there	PRON
dti-1407	119	24	are	be	VERB
dti-1407	119	25	several	several	ADJ
dti-1407	119	26	isotypes.17	isotypes.17	NOUN
dti-1407	119	27	the	the	DET
dti-1407	119	28	different	different	ADJ
dti-1407	119	29	isotypes	isotype	NOUN
dti-1407	119	30	of	of	ADP
dti-1407	119	31	tubulin	tubulin	NOUN
dti-1407	119	32	in	in	ADP
dti-1407	119	33	human	human	ADJ
dti-1407	119	34	beings	being	NOUN
dti-1407	119	35	are	be	AUX
dti-1407	119	36	summarized	summarize	VERB
dti-1407	119	37	in	in	ADP
dti-1407	119	38	table	table	NOUN
dti-1407	119	39	4	4	NUM
dti-1407	119	40	.	.	PUNCT
dti-1407	120	1	microtubules	microtubule	NOUN
dti-1407	120	2	play	play	VERB
dti-1407	120	3	many	many	ADJ
dti-1407	120	4	roles	role	NOUN
dti-1407	120	5	in	in	ADP
dti-1407	120	6	eukaryotic	eukaryotic	ADJ
dti-1407	120	7	cells	cell	NOUN
dti-1407	120	8	,	,	PUNCT
dti-1407	120	9	including	include	VERB
dti-1407	120	10	development	development	NOUN
dti-1407	120	11	and	and	CCONJ
dti-1407	120	12	maintenance	maintenance	NOUN
dti-1407	120	13	of	of	ADP
dti-1407	120	14	cell	cell	NOUN
dti-1407	120	15	shape,18	shape,18	NOUN
dti-1407	120	16	intracellular	intracellular	ADJ
dti-1407	120	17	transport,19	transport,19	NOUN
dti-1407	120	18	cell	cell	NOUN
dti-1407	120	19	motility,20,21	motility,20,21	PROPN
dti-1407	120	20	cell	cell	NOUN
dti-1407	120	21	signaling,22	signaling,22	NOUN
dti-1407	120	22	and	and	CCONJ
dti-1407	120	23	cell	cell	NOUN
dti-1407	120	24	division.23	division.23	PROPN
dti-1407	120	25	cell	cell	NOUN
dti-1407	120	26	division	division	NOUN
dti-1407	120	27	,	,	PUNCT
dti-1407	120	28	or	or	CCONJ
dti-1407	120	29	mitosis	mitosis	NOUN
dti-1407	120	30	,	,	PUNCT
dti-1407	120	31	is	be	AUX
dti-1407	120	32	a	a	DET
dti-1407	120	33	crucial	crucial	ADJ
dti-1407	120	34	event	event	NOUN
dti-1407	120	35	in	in	ADP
dti-1407	120	36	the	the	DET
dti-1407	120	37	cell	cell	NOUN
dti-1407	120	38	cycle	cycle	NOUN
dti-1407	120	39	that	that	PRON
dti-1407	120	40	results	result	VERB
dti-1407	120	41	in	in	ADP
dti-1407	120	42	the	the	DET
dti-1407	120	43	division	division	NOUN
dti-1407	120	44	of	of	ADP
dti-1407	120	45	a	a	DET
dti-1407	120	46	single	single	ADJ
dti-1407	120	47	cell	cell	NOUN
dti-1407	120	48	into	into	ADP
dti-1407	120	49	two	two	NUM
dti-1407	120	50	identical	identical	ADJ
dti-1407	120	51	daughter	daughter	NOUN
dti-1407	120	52	cells	cell	NOUN
dti-1407	120	53	with	with	ADP
dti-1407	120	54	the	the	DET
dti-1407	120	55	equal	equal	ADJ
dti-1407	120	56	distribution	distribution	NOUN
dti-1407	120	57	of	of	ADP
dti-1407	120	58	genetic	genetic	ADJ
dti-1407	120	59	materials	material	NOUN
dti-1407	120	60	(	(	PUNCT
dti-1407	120	61	fig	fig	NOUN
dti-1407	120	62	.	.	PUNCT
dti-1407	120	63	1	1	NUM
dti-1407	120	64	)	)	PUNCT
dti-1407	120	65	.	.	PUNCT
dti-1407	121	1	during	during	ADP
dti-1407	121	2	mitosis	mitosis	NOUN
dti-1407	121	3	,	,	PUNCT
dti-1407	121	4	the	the	DET
dti-1407	121	5	cytoskeleton	cytoskeleton	NOUN
dti-1407	121	6	forms	form	VERB
dti-1407	121	7	a	a	DET
dti-1407	121	8	superstructure	superstructure	NOUN
dti-1407	121	9	called	call	VERB
dti-1407	121	10	the	the	DET
dti-1407	121	11	mitotic	mitotic	ADJ
dti-1407	121	12	spindle	spindle	NOUN
dti-1407	121	13	,	,	PUNCT
dti-1407	121	14	which	which	PRON
dti-1407	121	15	facilitates	facilitate	VERB
dti-1407	121	16	many	many	ADJ
dti-1407	121	17	of	of	ADP
dti-1407	121	18	the	the	DET
dti-1407	121	19	cell	cell	NOUN
dti-1407	121	20	division	division	NOUN
dti-1407	121	21	processes	process	NOUN
dti-1407	121	22	.	.	PUNCT
dti-1407	122	1	mitosis	mitosis	NOUN
dti-1407	122	2	involves	involve	VERB
dti-1407	122	3	a	a	DET
dti-1407	122	4	series	series	NOUN
dti-1407	122	5	of	of	ADP
dti-1407	122	6	stages	stage	NOUN
dti-1407	122	7	.	.	PUNCT
dti-1407	123	1	the	the	DET
dti-1407	123	2	initial	initial	ADJ
dti-1407	123	3	prophase	prophase	NOUN
dti-1407	123	4	and	and	CCONJ
dti-1407	123	5	prometaphase	prometaphase	NOUN
dti-1407	123	6	stages	stage	NOUN
dti-1407	123	7	are	be	AUX
dti-1407	123	8	where	where	SCONJ
dti-1407	123	9	there	there	PRON
dti-1407	123	10	is	be	VERB
dti-1407	123	11	condensation	condensation	NOUN
dti-1407	123	12	of	of	ADP
dti-1407	123	13	chromosomes	chromosome	NOUN
dti-1407	123	14	,	,	PUNCT
dti-1407	123	15	which	which	PRON
dti-1407	123	16	then	then	ADV
dti-1407	123	17	attaches	attach	VERB
dti-1407	123	18	to	to	ADP
dti-1407	123	19	the	the	DET
dti-1407	123	20	mitotic	mitotic	ADJ
dti-1407	123	21	spindle	spindle	NOUN
dti-1407	123	22	.	.	PUNCT
dti-1407	124	1	the	the	DET
dti-1407	124	2	chromosomes	chromosome	NOUN
dti-1407	124	3	then	then	ADV
dti-1407	124	4	align	align	VERB
dti-1407	124	5	at	at	ADP
dti-1407	124	6	the	the	DET
dti-1407	124	7	equator	equator	NOUN
dti-1407	124	8	of	of	ADP
dti-1407	124	9	the	the	DET
dti-1407	124	10	mitotic	mitotic	ADJ
dti-1407	124	11	spindle	spindle	NOUN
dti-1407	124	12	(	(	PUNCT
dti-1407	124	13	metaphase	metaphase	NOUN
dti-1407	124	14	)	)	PUNCT
dti-1407	124	15	before	before	SCONJ
dti-1407	124	16	the	the	DET
dti-1407	124	17	sister	sister	NOUN
dti-1407	124	18	chromosomes	chromosome	NOUN
dti-1407	124	19	segregate	segregate	VERB
dti-1407	124	20	into	into	ADP
dti-1407	124	21	daughter	daughter	NOUN
dti-1407	124	22	cells	cell	NOUN
dti-1407	124	23	(	(	PUNCT
dti-1407	124	24	anaphase	anaphase	PROPN
dti-1407	124	25	)	)	PUNCT
dti-1407	124	26	.	.	PUNCT
dti-1407	125	1	the	the	DET
dti-1407	125	2	final	final	ADJ
dti-1407	125	3	stage	stage	NOUN
dti-1407	125	4	is	be	AUX
dti-1407	125	5	where	where	SCONJ
dti-1407	125	6	the	the	DET
dti-1407	125	7	chromosomes	chromosome	NOUN
dti-1407	125	8	decondense	decondense	NOUN
dti-1407	125	9	and	and	CCONJ
dti-1407	125	10	the	the	DET
dti-1407	125	11	cells	cell	NOUN
dti-1407	125	12	divide	divide	VERB
dti-1407	125	13	fully	fully	ADV
dti-1407	125	14	into	into	ADP
dti-1407	125	15	two	two	NUM
dti-1407	125	16	daughter	daughter	NOUN
dti-1407	125	17	cells	cell	NOUN
dti-1407	125	18	(	(	PUNCT
dti-1407	125	19	telophase	telophase	NOUN
dti-1407	125	20	)	)	PUNCT
dti-1407	125	21	.	.	PUNCT
dti-1407	126	1	all	all	DET
dti-1407	126	2	the	the	DET
dti-1407	126	3	stages	stage	NOUN
dti-1407	126	4	of	of	ADP
dti-1407	126	5	mitosis	mitosis	NOUN
dti-1407	126	6	must	must	AUX
dti-1407	126	7	be	be	AUX
dti-1407	126	8	regulated	regulate	VERB
dti-1407	126	9	for	for	ADP
dti-1407	126	10	the	the	DET
dti-1407	126	11	proper	proper	ADJ
dti-1407	126	12	development	development	NOUN
dti-1407	126	13	and	and	CCONJ
dti-1407	126	14	function	function	NOUN
dti-1407	126	15	of	of	ADP
dti-1407	126	16	a	a	DET
dti-1407	126	17	multicellular	multicellular	ADJ
dti-1407	126	18	organism	organism	NOUN
dti-1407	126	19	.	.	PUNCT
dti-1407	127	1	central	central	ADJ
dti-1407	127	2	to	to	ADP
dti-1407	127	3	the	the	DET
dti-1407	127	4	function	function	NOUN
dti-1407	127	5	of	of	ADP
dti-1407	127	6	microtubules	microtubule	NOUN
dti-1407	127	7	is	be	AUX
dti-1407	127	8	the	the	DET
dti-1407	127	9	regulation	regulation	NOUN
dti-1407	127	10	of	of	ADP
dti-1407	127	11	microtubule	microtubule	NOUN
dti-1407	127	12	dynamics	dynamic	NOUN
dti-1407	127	13	.	.	PUNCT
dti-1407	128	1	microtubule	microtubule	NOUN
dti-1407	128	2	filaments	filament	NOUN
dti-1407	128	3	are	be	AUX
dti-1407	128	4	able	able	ADJ
dti-1407	128	5	to	to	PART
dti-1407	128	6	polymerize	polymerize	VERB
dti-1407	128	7	and	and	CCONJ
dti-1407	128	8	depolymerize	depolymerize	VERB
dti-1407	128	9	stochastically	stochastically	ADV
dti-1407	128	10	within	within	ADP
dti-1407	128	11	a	a	DET
dti-1407	128	12	cell	cell	NOUN
dti-1407	128	13	,	,	PUNCT
dti-1407	128	14	in	in	ADP
dti-1407	128	15	what	what	PRON
dti-1407	128	16	is	be	AUX
dti-1407	128	17	termed	term	VERB
dti-1407	128	18	http://www.la-press.com/drug-target-insights-journal-j23	http://www.la-press.com/drug-target-insights-journal-j23	PROPN
dti-1407	128	19	http://www.la-press.com	http://www.la-press.com	X
dti-1407	128	20	zulkipli	zulkipli	PROPN
dti-1407	128	21	et	et	PROPN
dti-1407	128	22	al	al	PROPN
dti-1407	128	23	12	12	NUM
dti-1407	128	24	drug	drug	NOUN
dti-1407	128	25	target	target	NOUN
dti-1407	128	26	insights	insight	NOUN
dti-1407	128	27	2015:9	2015:9	NUM
dti-1407	128	28	ta	ta	X
dti-1407	128	29	bl	bl	PROPN
dti-1407	128	30	e	e	PROPN
dti-1407	128	31	3	3	NUM
dti-1407	128	32	.	.	PUNCT
dti-1407	129	1	c	c	VERB
dti-1407	129	2	he	he	PRON
dti-1407	129	3	m	m	VERB
dti-1407	130	1	ic	ic	VERB
dti-1407	130	2	al	al	PROPN
dti-1407	130	3	s	s	PROPN
dti-1407	131	1	tru	tru	PROPN
dti-1407	131	2	ct	ct	INTJ
dti-1407	131	3	ur	ur	INTJ
dti-1407	131	4	es	es	ADP
dti-1407	131	5	o	o	PROPN
dti-1407	131	6	f	f	X
dti-1407	131	7	n	n	CCONJ
dti-1407	131	8	at	at	ADP
dti-1407	131	9	ur	ur	INTJ
dti-1407	131	10	al	al	PROPN
dti-1407	131	11	m	m	PROPN
dti-1407	131	12	ic	ic	PROPN
dti-1407	131	13	ro	ro	PROPN
dti-1407	131	14	tu	tu	PROPN
dti-1407	131	15	bu	bu	PROPN
dti-1407	131	16	le	le	PROPN
dti-1407	131	17	-ta	-ta	AUX
dti-1407	131	18	rg	rg	X
dti-1407	131	19	et	et	NOUN
dti-1407	131	20	in	in	ADP
dti-1407	131	21	g	g	PROPN
dti-1407	131	22	co	co	PROPN
dti-1407	131	23	m	m	PROPN
dti-1407	131	24	po	po	PROPN
dti-1407	131	25	un	un	PROPN
dti-1407	131	26	ds	ds	PROPN
dti-1407	131	27	a	a	PRON
dti-1407	131	28	nd	nd	ADV
dti-1407	131	29	th	th	X
dti-1407	131	30	ei	ei	NOUN
dti-1407	131	31	r	r	NOUN
dti-1407	131	32	s	s	PROPN
dti-1407	131	33	yn	yn	X
dti-1407	131	34	th	th	X
dti-1407	131	35	et	et	NOUN
dti-1407	131	36	ic	ic	PROPN
dti-1407	132	1	a	a	DET
dti-1407	132	2	nd	nd	NOUN
dti-1407	132	3	s	s	PRON
dti-1407	132	4	em	em	PRON
dti-1407	132	5	is	be	AUX
dti-1407	132	6	yn	yn	ADP
dti-1407	132	7	th	th	INTJ
dti-1407	132	8	et	et	NOUN
dti-1407	133	1	ic	ic	PROPN
dti-1407	134	1	d	d	X
dti-1407	134	2	er	er	INTJ
dti-1407	134	3	iv	iv	X
dti-1407	134	4	at	at	ADP
dti-1407	134	5	iv	iv	ADP
dti-1407	134	6	es	es	X
dti-1407	134	7	.	.	PUNCT
dti-1407	135	1	vi	vi	PROPN
dti-1407	135	2	nb	nb	PROPN
dti-1407	135	3	la	la	PROPN
dti-1407	135	4	st	st	PROPN
dti-1407	135	5	in	in	ADP
dti-1407	135	6	e	e	PROPN
dti-1407	135	7	vi	vi	PROPN
dti-1407	135	8	nc	nc	PROPN
dti-1407	135	9	ri	ri	PROPN
dti-1407	135	10	st	st	PROPN
dti-1407	135	11	in	in	ADP
dti-1407	135	12	e	e	PROPN
dti-1407	135	13	vi	vi	PROPN
dti-1407	135	14	nd	nd	NOUN
dti-1407	135	15	es	es	NOUN
dti-1407	135	16	in	in	ADP
dti-1407	135	17	e	e	PROPN
dti-1407	135	18	vi	vi	PROPN
dti-1407	135	19	nfl	nfl	PROPN
dti-1407	135	20	un	un	PROPN
dti-1407	135	21	in	in	ADP
dti-1407	135	22	e	e	PROPN
dti-1407	135	23	vi	vi	VERB
dti-1407	135	24	no	no	PRON
dti-1407	135	25	re	re	NOUN
dti-1407	135	26	lb	lb	NOUN
dti-1407	135	27	in	in	ADP
dti-1407	135	28	e	e	PROPN
dti-1407	135	29	http://www.la-press.com	http://www.la-press.com	X
dti-1407	135	30	http://www.la-press.com/drug-target-insights-journal-j23	http://www.la-press.com/drug-target-insights-journal-j23	PROPN
dti-1407	135	31	13drug	13drug	NUM
dti-1407	135	32	target	target	NOUN
dti-1407	135	33	insights	insight	VERB
dti-1407	135	34	2015:9	2015:9	PRON
dti-1407	135	35	medicinal	medicinal	ADJ
dti-1407	135	36	plants	plant	NOUN
dti-1407	135	37	:	:	PUNCT
dti-1407	135	38	a	a	DET
dti-1407	135	39	potential	potential	ADJ
dti-1407	135	40	source	source	NOUN
dti-1407	135	41	of	of	ADP
dti-1407	135	42	compounds	compound	NOUN
dti-1407	135	43	for	for	ADP
dti-1407	135	44	targeting	target	VERB
dti-1407	135	45	cell	cell	NOUN
dti-1407	135	46	division	division	NOUN
dti-1407	135	47	pa	pa	PROPN
dti-1407	135	48	cl	cl	PROPN
dti-1407	135	49	ita	ita	PROPN
dti-1407	136	1	xe	xe	PROPN
dti-1407	136	2	l	l	PROPN
dti-1407	137	1	d	d	NOUN
dti-1407	137	2	oc	oc	VERB
dti-1407	137	3	et	et	NOUN
dti-1407	137	4	ax	ax	NOUN
dti-1407	137	5	el	el	PROPN
dti-1407	137	6	c	c	PROPN
dti-1407	137	7	ab	ab	PROPN
dti-1407	137	8	az	az	PROPN
dti-1407	137	9	ita	ita	PROPN
dti-1407	137	10	xe	xe	PROPN
dti-1407	137	11	l	l	PROPN
dti-1407	137	12	la	la	INTJ
dti-1407	137	13	ro	ro	X
dti-1407	137	14	ta	ta	X
dti-1407	138	1	xe	xe	PROPN
dti-1407	138	2	l	l	PROPN
dti-1407	138	3	te	te	X
dti-1407	138	4	se	se	X
dti-1407	138	5	ta	ta	PROPN
dti-1407	138	6	xe	xe	PROPN
dti-1407	138	7	l	l	PROPN
dti-1407	139	1	c	c	NOUN
dti-1407	139	2	om	om	INTJ
dti-1407	139	3	br	br	NOUN
dti-1407	139	4	es	es	X
dti-1407	139	5	ta	ta	ADP
dti-1407	139	6	tin	tin	NOUN
dti-1407	139	7	o	o	NOUN
dti-1407	139	8	m	m	VERB
dti-1407	139	9	br	br	NOUN
dti-1407	139	10	ab	ab	PROPN
dti-1407	139	11	ul	ul	PROPN
dti-1407	139	12	in	in	ADP
dti-1407	139	13	fi	fi	NOUN
dti-1407	139	14	sb	sb	PROPN
dti-1407	139	15	re	re	ADP
dti-1407	139	16	ta	ta	PROPN
dti-1407	139	17	bu	bu	PROPN
dti-1407	139	18	lin	lin	PROPN
dti-1407	139	19	(	(	PUNCT
dti-1407	139	20	c	c	NOUN
dti-1407	139	21	on	on	ADP
dti-1407	139	22	tin	tin	NOUN
dti-1407	139	23	ue	ue	PROPN
dti-1407	139	24	d	d	PROPN
dti-1407	139	25	)	)	PUNCT
dti-1407	139	26	http://www.la-press.com/drug-target-insights-journal-j23	http://www.la-press.com/drug-target-insights-journal-j23	PROPN
dti-1407	139	27	http://www.la-press.com	http://www.la-press.com	X
dti-1407	140	1	zulkipli	zulkipli	PROPN
dti-1407	140	2	et	et	PROPN
dti-1407	140	3	al	al	PROPN
dti-1407	140	4	14	14	NUM
dti-1407	140	5	drug	drug	NOUN
dti-1407	140	6	target	target	NOUN
dti-1407	140	7	insights	insight	NOUN
dti-1407	140	8	2015:9	2015:9	NUM
dti-1407	140	9	c	c	NOUN
dti-1407	140	10	ro	ro	INTJ
dti-1407	140	11	lib	lib	PROPN
dti-1407	140	12	ul	ul	INTJ
dti-1407	140	13	in	in	ADP
dti-1407	140	14	ve	ve	PROPN
dti-1407	140	15	ru	ru	PROPN
dti-1407	140	16	bu	bu	PROPN
dti-1407	140	17	lin	lin	PROPN
dti-1407	140	18	c	c	PROPN
dti-1407	140	19	ol	ol	PROPN
dti-1407	140	20	ch	ch	PROPN
dti-1407	140	21	ic	ic	PROPN
dti-1407	140	22	in	in	ADP
dti-1407	140	23	e	e	PROPN
dti-1407	140	24	po	po	X
dti-1407	140	25	do	do	VERB
dti-1407	140	26	ph	ph	NOUN
dti-1407	140	27	yl	yl	NOUN
dti-1407	140	28	lo	lo	PROPN
dti-1407	140	29	to	to	ADP
dti-1407	140	30	xi	xi	PROPN
dti-1407	140	31	n	n	PROPN
dti-1407	140	32	n	n	ADV
dti-1407	141	1	os	os	NOUN
dti-1407	142	1	ca	can	AUX
dti-1407	142	2	pi	pi	NOUN
dti-1407	142	3	ne	ne	VERB
dti-1407	142	4	ta	ta	PROPN
dti-1407	142	5	bl	bl	PROPN
dti-1407	142	6	e	e	PROPN
dti-1407	142	7	3	3	X
dti-1407	142	8	.	.	PUNCT
dti-1407	143	1	(	(	PUNCT
dti-1407	143	2	c	c	NOUN
dti-1407	143	3	on	on	ADP
dti-1407	143	4	tin	tin	NOUN
dti-1407	143	5	ue	ue	PROPN
dti-1407	143	6	d	d	PROPN
dti-1407	143	7	)	)	PUNCT
dti-1407	143	8	http://www.la-press.com	http://www.la-press.com	X
dti-1407	144	1	http://www.la-press.com/drug-target-insights-journal-j23	http://www.la-press.com/drug-target-insights-journal-j23	PROPN
dti-1407	144	2	15drug	15drug	X
dti-1407	144	3	target	target	NOUN
dti-1407	144	4	insights	insight	VERB
dti-1407	144	5	2015:9	2015:9	PRON
dti-1407	144	6	medicinal	medicinal	ADJ
dti-1407	144	7	plants	plant	NOUN
dti-1407	144	8	:	:	PUNCT
dti-1407	144	9	a	a	DET
dti-1407	144	10	potential	potential	ADJ
dti-1407	144	11	source	source	NOUN
dti-1407	144	12	of	of	ADP
dti-1407	144	13	compounds	compound	NOUN
dti-1407	144	14	for	for	ADP
dti-1407	144	15	targeting	target	VERB
dti-1407	144	16	cell	cell	NOUN
dti-1407	144	17	division	division	NOUN
dti-1407	144	18	table	table	NOUN
dti-1407	144	19	4	4	NUM
dti-1407	144	20	.	.	PUNCT
dti-1407	144	21	subtypes	subtype	NOUN
dti-1407	144	22	and	and	CCONJ
dti-1407	144	23	isoforms	isoform	NOUN
dti-1407	144	24	of	of	ADP
dti-1407	144	25	microtubules	microtubule	NOUN
dti-1407	144	26	.	.	PUNCT
dti-1407	145	1	tubulin	tubulin	NOUN
dti-1407	145	2	subtype	subtype	NOUN
dti-1407	145	3	isotype	isotype	NOUN
dti-1407	145	4	gene	gene	NOUN
dti-1407	145	5	length	length	NOUN
dti-1407	145	6	(	(	PUNCT
dti-1407	145	7	amino	amino	NOUN
dti-1407	145	8	acids	acid	NOUN
dti-1407	145	9	)	)	PUNCT
dti-1407	145	10	tissue	tissue	NOUN
dti-1407	145	11	distribution	distribution	NOUN
dti-1407	145	12	putative	putative	ADJ
dti-1407	145	13	function	function	NOUN
dti-1407	145	14	(	(	PUNCT
dti-1407	145	15	if	if	SCONJ
dti-1407	145	16	any	any	PRON
dti-1407	145	17	)	)	PUNCT
dti-1407	145	18	altered	altered	ADJ
dti-1407	145	19	expression	expression	NOUN
dti-1407	145	20	in	in	ADP
dti-1407	145	21	cancers	cancer	NOUN
dti-1407	145	22	?	?	PUNCT
dti-1407	146	1	α	α	PRON
dti-1407	146	2	1a	1a	NOUN
dti-1407	146	3	tuba1a	tuba1a	ADJ
dti-1407	146	4	451	451	NUM
dti-1407	146	5	ubiquitous	ubiquitous	ADJ
dti-1407	146	6	no	no	DET
dti-1407	146	7	isoform	isoform	NOUN
dti-1407	146	8	-	-	PUNCT
dti-1407	146	9	specific	specific	ADJ
dti-1407	146	10	function	function	NOUN
dti-1407	146	11	identified	identify	VERB
dti-1407	146	12	no	no	DET
dti-1407	146	13	1b	1b	NUM
dti-1407	146	14	tuba1b	tuba1b	NUM
dti-1407	146	15	451	451	NUM
dti-1407	146	16	ubiquitous	ubiquitous	ADJ
dti-1407	146	17	no	no	DET
dti-1407	146	18	1c	1c	NOUN
dti-1407	146	19	tuba1c	tuba1c	NOUN
dti-1407	146	20	449	449	NUM
dti-1407	146	21	ubiquitous	ubiquitous	ADJ
dti-1407	146	22	no	no	DET
dti-1407	146	23	3c	3c	NUM
dti-1407	146	24	tuba3c	tuba3c	NOUN
dti-1407	146	25	450	450	NUM
dti-1407	146	26	enriched	enriched	ADJ
dti-1407	146	27	expression	expression	NOUN
dti-1407	146	28	in	in	ADP
dti-1407	146	29	testis	testis	NOUN
dti-1407	146	30	,	,	PUNCT
dti-1407	146	31	fallopian	fallopian	ADJ
dti-1407	146	32	tube	tube	NOUN
dti-1407	146	33	,	,	PUNCT
dti-1407	146	34	soft	soft	ADJ
dti-1407	146	35	tissues	tissue	NOUN
dti-1407	146	36	,	,	PUNCT
dti-1407	146	37	central	central	ADJ
dti-1407	146	38	nervous	nervous	ADJ
dti-1407	146	39	system	system	NOUN
dti-1407	146	40	and	and	CCONJ
dti-1407	146	41	other	other	ADJ
dti-1407	146	42	selected	select	VERB
dti-1407	146	43	tissues	tissue	NOUN
dti-1407	146	44	variable	variable	ADJ
dti-1407	146	45	expression	expression	NOUN
dti-1407	146	46	3d	3d	PROPN
dti-1407	146	47	tuba3d	tuba3d	NUM
dti-1407	146	48	450	450	NUM
dti-1407	146	49	enriched	enriched	ADJ
dti-1407	146	50	expression	expression	NOUN
dti-1407	146	51	in	in	ADP
dti-1407	146	52	testis	testis	NOUN
dti-1407	146	53	,	,	PUNCT
dti-1407	146	54	fallopian	fallopian	ADJ
dti-1407	146	55	tube	tube	NOUN
dti-1407	146	56	,	,	PUNCT
dti-1407	146	57	soft	soft	ADJ
dti-1407	146	58	tissues	tissue	NOUN
dti-1407	146	59	,	,	PUNCT
dti-1407	146	60	central	central	ADJ
dti-1407	146	61	nervous	nervous	ADJ
dti-1407	146	62	system	system	NOUN
dti-1407	146	63	and	and	CCONJ
dti-1407	146	64	other	other	ADJ
dti-1407	146	65	selected	select	VERB
dti-1407	146	66	tissues	tissue	NOUN
dti-1407	146	67	decreased	decrease	VERB
dti-1407	146	68	3e	3e	NOUN
dti-1407	146	69	tuba3e	tuba3e	NOUN
dti-1407	146	70	448	448	NUM
dti-1407	146	71	enriched	enriched	ADJ
dti-1407	146	72	expression	expression	NOUN
dti-1407	146	73	in	in	ADP
dti-1407	146	74	testis	testis	NOUN
dti-1407	146	75	,	,	PUNCT
dti-1407	146	76	fallopian	fallopian	ADJ
dti-1407	146	77	tube	tube	NOUN
dti-1407	146	78	,	,	PUNCT
dti-1407	146	79	soft	soft	ADJ
dti-1407	146	80	tissues	tissue	NOUN
dti-1407	146	81	,	,	PUNCT
dti-1407	146	82	central	central	ADJ
dti-1407	146	83	nervous	nervous	ADJ
dti-1407	146	84	system	system	NOUN
dti-1407	146	85	and	and	CCONJ
dti-1407	146	86	other	other	ADJ
dti-1407	146	87	selected	select	VERB
dti-1407	146	88	tissues	tissue	NOUN
dti-1407	146	89	decreased	decrease	VERB
dti-1407	146	90	4a	4a	NUM
dti-1407	146	91	tuba4a	tuba4a	NOUN
dti-1407	146	92	446	446	NUM
dti-1407	146	93	ubiquitous	ubiquitous	ADJ
dti-1407	146	94	no	no	DET
dti-1407	146	95	8	8	NUM
dti-1407	146	96	tuba8	tuba8	NOUN
dti-1407	146	97	449	449	NUM
dti-1407	146	98	ubiquitous	ubiquitous	ADJ
dti-1407	146	99	,	,	PUNCT
dti-1407	146	100	but	but	CCONJ
dti-1407	146	101	enriched	enrich	VERB
dti-1407	146	102	in	in	ADP
dti-1407	146	103	heart	heart	NOUN
dti-1407	146	104	muscle	muscle	NOUN
dti-1407	146	105	,	,	PUNCT
dti-1407	146	106	skeletal	skeletal	ADJ
dti-1407	146	107	muscle	muscle	NOUN
dti-1407	146	108	and	and	CCONJ
dti-1407	146	109	testis	testis	NOUN
dti-1407	146	110	decreased	decrease	VERB
dti-1407	146	111	β	β	X
dti-1407	146	112	1	1	NUM
dti-1407	146	113	tubb1	tubb1	NOUN
dti-1407	146	114	451	451	NUM
dti-1407	146	115	enriched	enrich	VERB
dti-1407	146	116	in	in	ADP
dti-1407	146	117	haematopoietic	haematopoietic	ADJ
dti-1407	146	118	cells	cell	NOUN
dti-1407	146	119	may	may	AUX
dti-1407	146	120	play	play	VERB
dti-1407	146	121	a	a	DET
dti-1407	146	122	role	role	NOUN
dti-1407	146	123	in	in	ADP
dti-1407	146	124	microtubule	microtubule	NOUN
dti-1407	146	125	stability	stability	NOUN
dti-1407	146	126	,	,	PUNCT
dti-1407	146	127	as	as	ADV
dti-1407	146	128	well	well	ADV
dti-1407	146	129	as	as	ADP
dti-1407	146	130	interaction	interaction	NOUN
dti-1407	146	131	with	with	ADP
dti-1407	146	132	actin	actin	NOUN
dti-1407	146	133	increased	increase	VERB
dti-1407	146	134	on	on	ADP
dti-1407	146	135	exposure	exposure	NOUN
dti-1407	146	136	to	to	ADP
dti-1407	146	137	microtubuletargeting	microtubuletargete	VERB
dti-1407	146	138	drugs	drug	NOUN
dti-1407	146	139	2a	2a	NUM
dti-1407	146	140	tubb2a	tubb2a	NOUN
dti-1407	146	141	445	445	NUM
dti-1407	146	142	ubiquitous	ubiquitous	ADJ
dti-1407	146	143	,	,	PUNCT
dti-1407	146	144	enriched	enrich	VERB
dti-1407	146	145	in	in	ADP
dti-1407	146	146	brain	brain	NOUN
dti-1407	146	147	may	may	AUX
dti-1407	146	148	play	play	VERB
dti-1407	146	149	a	a	DET
dti-1407	146	150	role	role	NOUN
dti-1407	146	151	in	in	ADP
dti-1407	146	152	neuronal	neuronal	ADJ
dti-1407	146	153	differentation	differentation	NOUN
dti-1407	146	154	increased	increase	VERB
dti-1407	146	155	in	in	ADP
dti-1407	146	156	microtubule	microtubule	NOUN
dti-1407	146	157	-	-	PUNCT
dti-1407	146	158	targeting	target	VERB
dti-1407	146	159	drug	drug	NOUN
dti-1407	146	160	-	-	PUNCT
dti-1407	146	161	resistant	resistant	ADJ
dti-1407	146	162	cancers	cancer	NOUN
dti-1407	146	163	2b	2b	NOUN
dti-1407	146	164	tubb2b	tubb2b	PROPN
dti-1407	146	165	445	445	NUM
dti-1407	146	166	ubiquitous	ubiquitous	ADJ
dti-1407	146	167	,	,	PUNCT
dti-1407	146	168	enriched	enrich	VERB
dti-1407	146	169	in	in	ADP
dti-1407	146	170	brain	brain	NOUN
dti-1407	146	171	may	may	AUX
dti-1407	146	172	play	play	VERB
dti-1407	146	173	a	a	DET
dti-1407	146	174	role	role	NOUN
dti-1407	146	175	in	in	ADP
dti-1407	146	176	neuronal	neuronal	ADJ
dti-1407	146	177	differentation	differentation	NOUN
dti-1407	146	178	no	no	DET
dti-1407	146	179	3	3	NUM
dti-1407	146	180	tubb3	tubb3	NOUN
dti-1407	146	181	450	450	NUM
dti-1407	146	182	mostly	mostly	ADV
dti-1407	146	183	expressed	express	VERB
dti-1407	146	184	in	in	ADP
dti-1407	146	185	central	central	ADJ
dti-1407	146	186	and	and	CCONJ
dti-1407	146	187	peripheral	peripheral	ADJ
dti-1407	146	188	nervous	nervous	ADJ
dti-1407	146	189	system	system	NOUN
dti-1407	146	190	may	may	AUX
dti-1407	146	191	play	play	VERB
dti-1407	146	192	a	a	DET
dti-1407	146	193	role	role	NOUN
dti-1407	146	194	in	in	ADP
dti-1407	146	195	neuronal	neuronal	ADJ
dti-1407	146	196	differentiation	differentiation	NOUN
dti-1407	146	197	.	.	PUNCT
dti-1407	147	1	may	may	AUX
dti-1407	147	2	help	help	VERB
dti-1407	147	3	cells	cell	NOUN
dti-1407	147	4	cope	cope	VERB
dti-1407	147	5	with	with	ADP
dti-1407	147	6	oxidative	oxidative	ADJ
dti-1407	147	7	stress	stress	NOUN
dti-1407	147	8	overexpressed	overexpresse	VERB
dti-1407	147	9	in	in	ADP
dti-1407	147	10	aggressive	aggressive	ADJ
dti-1407	147	11	tumours	tumour	NOUN
dti-1407	147	12	4a	4a	NOUN
dti-1407	148	1	tubb4a	tubb4a	PRON
dti-1407	148	2	444	444	NUM
dti-1407	148	3	highly	highly	ADV
dti-1407	148	4	expressed	express	VERB
dti-1407	148	5	in	in	ADP
dti-1407	148	6	brain	brain	NOUN
dti-1407	148	7	,	,	PUNCT
dti-1407	148	8	moderate	moderate	ADJ
dti-1407	148	9	levels	level	NOUN
dti-1407	148	10	in	in	ADP
dti-1407	148	11	testis	testis	NOUN
dti-1407	148	12	,	,	PUNCT
dti-1407	148	13	very	very	ADV
dti-1407	148	14	low	low	ADJ
dti-1407	148	15	levels	level	NOUN
dti-1407	148	16	in	in	ADP
dti-1407	148	17	other	other	ADJ
dti-1407	148	18	tissues	tissue	NOUN
dti-1407	148	19	occurs	occur	VERB
dti-1407	148	20	in	in	ADP
dti-1407	148	21	axonemes	axoneme	NOUN
dti-1407	148	22	,	,	PUNCT
dti-1407	148	23	may	may	AUX
dti-1407	148	24	be	be	AUX
dti-1407	148	25	required	require	VERB
dti-1407	148	26	for	for	ADP
dti-1407	148	27	determination	determination	NOUN
dti-1407	148	28	of	of	ADP
dti-1407	148	29	axonemal	axonemal	ADJ
dti-1407	148	30	microtubule	microtubule	NOUN
dti-1407	148	31	structure	structure	NOUN
dti-1407	148	32	increased	increase	VERB
dti-1407	148	33	on	on	ADP
dti-1407	148	34	exposure	exposure	NOUN
dti-1407	148	35	to	to	ADP
dti-1407	148	36	microtubuletargeting	microtubuletargete	VERB
dti-1407	148	37	drugs	drug	NOUN
dti-1407	148	38	4b	4b	PROPN
dti-1407	148	39	tubb4b	tubb4b	PROPN
dti-1407	148	40	445	445	NUM
dti-1407	148	41	ubiquitous	ubiquitous	ADJ
dti-1407	148	42	occurs	occur	NOUN
dti-1407	148	43	in	in	ADP
dti-1407	148	44	axonemes	axoneme	NOUN
dti-1407	148	45	,	,	PUNCT
dti-1407	148	46	may	may	AUX
dti-1407	148	47	be	be	AUX
dti-1407	148	48	required	require	VERB
dti-1407	148	49	for	for	ADP
dti-1407	148	50	determination	determination	NOUN
dti-1407	148	51	of	of	ADP
dti-1407	148	52	axonemal	axonemal	ADJ
dti-1407	148	53	microtubule	microtubule	NOUN
dti-1407	148	54	structure	structure	NOUN
dti-1407	148	55	no	no	DET
dti-1407	148	56	5	5	NUM
dti-1407	148	57	tubb	tubb	NOUN
dti-1407	148	58	444	444	NUM
dti-1407	148	59	ubiquitously	ubiquitously	ADV
dti-1407	148	60	expressed	express	VERB
dti-1407	148	61	with	with	ADP
dti-1407	148	62	highest	high	ADJ
dti-1407	148	63	levels	level	NOUN
dti-1407	148	64	in	in	ADP
dti-1407	148	65	spleen	spleen	NOUN
dti-1407	148	66	,	,	PUNCT
dti-1407	148	67	thymus	thymus	VERB
dti-1407	148	68	and	and	CCONJ
dti-1407	148	69	immature	immature	ADJ
dti-1407	148	70	brain	brain	NOUN
dti-1407	148	71	unknown	unknown	ADJ
dti-1407	148	72	unknown	unknown	ADJ
dti-1407	148	73	6	6	NUM
dti-1407	148	74	tubb6	tubb6	VERB
dti-1407	148	75	446	446	NUM
dti-1407	148	76	ubiquitous	ubiquitous	ADJ
dti-1407	148	77	,	,	PUNCT
dti-1407	148	78	with	with	SCONJ
dti-1407	148	79	highest	high	ADJ
dti-1407	148	80	expression	expression	NOUN
dti-1407	148	81	in	in	ADP
dti-1407	148	82	the	the	DET
dti-1407	148	83	breast	breast	NOUN
dti-1407	148	84	and	and	CCONJ
dti-1407	148	85	lung	lung	PROPN
dti-1407	148	86	unknown	unknown	NOUN
dti-1407	148	87	largely	largely	ADV
dti-1407	148	88	decreased	decrease	VERB
dti-1407	148	89	8	8	NUM
dti-1407	148	90	tubb8	tubb8	CCONJ
dti-1407	148	91	444	444	NUM
dti-1407	148	92	ubiquitous	ubiquitous	ADJ
dti-1407	148	93	,	,	PUNCT
dti-1407	148	94	enriched	enrich	VERB
dti-1407	148	95	in	in	ADP
dti-1407	148	96	cliliated	cliliate	VERB
dti-1407	148	97	cells	cell	NOUN
dti-1407	148	98	and	and	CCONJ
dti-1407	148	99	lymphoid	lymphoid	ADJ
dti-1407	148	100	tissue	tissue	NOUN
dti-1407	148	101	unknown	unknown	ADJ
dti-1407	148	102	unknown	unknown	ADJ
dti-1407	148	103	γ	γ	NOUN
dti-1407	148	104	1	1	NUM
dti-1407	148	105	tubg1	tubg1	NOUN
dti-1407	148	106	451	451	NUM
dti-1407	148	107	ubiquitous	ubiquitous	ADJ
dti-1407	148	108	important	important	ADJ
dti-1407	148	109	for	for	ADP
dti-1407	148	110	nucleation	nucleation	NOUN
dti-1407	148	111	and	and	CCONJ
dti-1407	148	112	polarity	polarity	NOUN
dti-1407	148	113	of	of	ADP
dti-1407	148	114	microtubules	microtubule	NOUN
dti-1407	148	115	,	,	PUNCT
dti-1407	148	116	mostly	mostly	ADV
dti-1407	148	117	found	find	VERB
dti-1407	148	118	in	in	ADP
dti-1407	148	119	microtubuleorganising	microtubuleorganise	VERB
dti-1407	148	120	centres	centre	NOUN
dti-1407	148	121	unknown	unknown	ADJ
dti-1407	148	122	2	2	NUM
dti-1407	148	123	tubg2	tubg2	NOUN
dti-1407	148	124	451	451	NUM
dti-1407	148	125	ubiquitous	ubiquitous	ADJ
dti-1407	148	126	important	important	ADJ
dti-1407	148	127	for	for	ADP
dti-1407	148	128	nucleation	nucleation	NOUN
dti-1407	148	129	and	and	CCONJ
dti-1407	148	130	polarity	polarity	NOUN
dti-1407	148	131	of	of	ADP
dti-1407	148	132	microtubules	microtubule	NOUN
dti-1407	148	133	,	,	PUNCT
dti-1407	148	134	mostly	mostly	ADV
dti-1407	148	135	found	find	VERB
dti-1407	148	136	in	in	ADP
dti-1407	148	137	microtubuleorganising	microtubuleorganise	VERB
dti-1407	148	138	centres	centre	NOUN
dti-1407	148	139	unknown	unknown	ADJ
dti-1407	148	140	δ	δ	PROPN
dti-1407	148	141	–	–	PUNCT
dti-1407	148	142	tubd1	tubd1	NOUN
dti-1407	148	143	453	453	NUM
dti-1407	148	144	ubiquitous	ubiquitous	ADJ
dti-1407	148	145	sperm	sperm	NOUN
dti-1407	148	146	differentiation	differentiation	NOUN
dti-1407	148	147	decreased	decrease	VERB
dti-1407	148	148	ε	ε	PROPN
dti-1407	148	149	–	–	PUNCT
dti-1407	148	150	tube1	tube1	NOUN
dti-1407	149	1	475	475	NUM
dti-1407	149	2	majority	majority	NOUN
dti-1407	149	3	of	of	ADP
dti-1407	149	4	tissues	tissue	NOUN
dti-1407	149	5	centrosome	centrosome	PROPN
dti-1407	149	6	cycle	cycle	NOUN
dti-1407	149	7	decreased	decrease	VERB
dti-1407	149	8	notes	note	NOUN
dti-1407	149	9	:	:	PUNCT
dti-1407	149	10	data	datum	NOUN
dti-1407	149	11	in	in	ADP
dti-1407	149	12	this	this	DET
dti-1407	149	13	table	table	NOUN
dti-1407	149	14	were	be	AUX
dti-1407	149	15	obtained	obtain	VERB
dti-1407	149	16	from	from	ADP
dti-1407	149	17	uniprot	uniprot	ADJ
dti-1407	149	18	(	(	PUNCT
dti-1407	149	19	http://www.uniprot.org	http://www.uniprot.org	NUM
dti-1407	149	20	)	)	PUNCT
dti-1407	149	21	and	and	CCONJ
dti-1407	149	22	proteinatlas	proteinatlas	PROPN
dti-1407	149	23	(	(	PUNCT
dti-1407	149	24	http://www.proteinatlas.org	http://www.proteinatlas.org	NUM
dti-1407	149	25	)	)	PUNCT
dti-1407	149	26	.	.	PUNCT
dti-1407	150	1	http://www.la-press.com/drug-target-insights-journal-j23	http://www.la-press.com/drug-target-insights-journal-j23	PROPN
dti-1407	150	2	http://www.la-press.com	http://www.la-press.com	X
dti-1407	150	3	zulkipli	zulkipli	PROPN
dti-1407	150	4	et	et	PROPN
dti-1407	150	5	al	al	PROPN
dti-1407	150	6	16	16	NUM
dti-1407	150	7	drug	drug	NOUN
dti-1407	150	8	target	target	NOUN
dti-1407	150	9	insights	insight	NOUN
dti-1407	150	10	2015:9	2015:9	NUM
dti-1407	150	11	figure	figure	NOUN
dti-1407	150	12	1	1	NUM
dti-1407	150	13	.	.	PUNCT
dti-1407	151	1	the	the	DET
dti-1407	151	2	process	process	NOUN
dti-1407	151	3	of	of	ADP
dti-1407	151	4	cell	cell	NOUN
dti-1407	151	5	division	division	NOUN
dti-1407	151	6	in	in	ADP
dti-1407	151	7	mammalian	mammalian	ADJ
dti-1407	151	8	cells	cell	NOUN
dti-1407	151	9	.	.	PUNCT
dti-1407	152	1	this	this	DET
dti-1407	152	2	figure	figure	NOUN
dti-1407	152	3	illustrates	illustrate	VERB
dti-1407	152	4	the	the	DET
dti-1407	152	5	different	different	ADJ
dti-1407	152	6	microtubule	microtubule	NOUN
dti-1407	152	7	structures	structure	NOUN
dti-1407	152	8	present	present	ADJ
dti-1407	152	9	during	during	ADP
dti-1407	152	10	different	different	ADJ
dti-1407	152	11	stages	stage	NOUN
dti-1407	152	12	of	of	ADP
dti-1407	152	13	the	the	DET
dti-1407	152	14	cell	cell	NOUN
dti-1407	152	15	cycle	cycle	NOUN
dti-1407	152	16	.	.	PUNCT
dti-1407	153	1	in	in	ADP
dti-1407	153	2	the	the	DET
dti-1407	153	3	interphase	interphase	NOUN
dti-1407	153	4	stage	stage	NOUN
dti-1407	153	5	of	of	ADP
dti-1407	153	6	the	the	DET
dti-1407	153	7	cell	cell	NOUN
dti-1407	153	8	cycle	cycle	NOUN
dti-1407	153	9	,	,	PUNCT
dti-1407	153	10	microtubules	microtubule	NOUN
dti-1407	153	11	(	(	PUNCT
dti-1407	153	12	green	green	ADJ
dti-1407	153	13	)	)	PUNCT
dti-1407	153	14	emanate	emanate	VERB
dti-1407	153	15	out	out	ADP
dti-1407	153	16	from	from	ADP
dti-1407	153	17	the	the	DET
dti-1407	153	18	microtubule	microtubule	NOUN
dti-1407	153	19	-	-	PUNCT
dti-1407	153	20	organizing	organize	VERB
dti-1407	153	21	center	center	NOUN
dti-1407	153	22	,	,	PUNCT
dti-1407	153	23	the	the	DET
dti-1407	153	24	centrosome	centrosome	NOUN
dti-1407	153	25	(	(	PUNCT
dti-1407	153	26	dark	dark	ADJ
dti-1407	153	27	blue	blue	ADJ
dti-1407	153	28	circle	circle	NOUN
dti-1407	153	29	)	)	PUNCT
dti-1407	153	30	,	,	PUNCT
dti-1407	153	31	forming	form	VERB
dti-1407	153	32	an	an	DET
dti-1407	153	33	array	array	NOUN
dti-1407	153	34	that	that	PRON
dti-1407	153	35	extends	extend	VERB
dti-1407	153	36	toward	toward	ADP
dti-1407	153	37	the	the	DET
dti-1407	153	38	cell	cell	NOUN
dti-1407	153	39	periphery	periphery	NOUN
dti-1407	153	40	.	.	PUNCT
dti-1407	154	1	during	during	ADP
dti-1407	154	2	the	the	DET
dti-1407	154	3	mitotic	mitotic	ADJ
dti-1407	154	4	stage	stage	NOUN
dti-1407	154	5	of	of	ADP
dti-1407	154	6	the	the	DET
dti-1407	154	7	cell	cell	NOUN
dti-1407	154	8	cycle	cycle	NOUN
dti-1407	154	9	,	,	PUNCT
dti-1407	154	10	the	the	DET
dti-1407	154	11	centrosomes	centrosome	NOUN
dti-1407	154	12	are	be	AUX
dti-1407	154	13	duplicated	duplicate	VERB
dti-1407	154	14	and	and	CCONJ
dti-1407	154	15	separated	separate	VERB
dti-1407	154	16	to	to	PART
dti-1407	154	17	form	form	VERB
dti-1407	154	18	spindle	spindle	NOUN
dti-1407	154	19	poles	pole	NOUN
dti-1407	154	20	,	,	PUNCT
dti-1407	154	21	while	while	SCONJ
dti-1407	154	22	the	the	DET
dti-1407	154	23	microtubule	microtubule	NOUN
dti-1407	154	24	cytoskeleton	cytoskeleton	NOUN
dti-1407	154	25	is	be	AUX
dti-1407	154	26	reorganized	reorganize	VERB
dti-1407	154	27	to	to	PART
dti-1407	154	28	form	form	VERB
dti-1407	154	29	a	a	DET
dti-1407	154	30	superstructure	superstructure	NOUN
dti-1407	154	31	called	call	VERB
dti-1407	154	32	the	the	DET
dti-1407	154	33	mitotic	mitotic	ADJ
dti-1407	154	34	spindle	spindle	NOUN
dti-1407	154	35	.	.	PUNCT
dti-1407	155	1	the	the	DET
dti-1407	155	2	mitotic	mitotic	ADJ
dti-1407	155	3	spindle	spindle	NOUN
dti-1407	155	4	is	be	AUX
dti-1407	155	5	responsible	responsible	ADJ
dti-1407	155	6	for	for	ADP
dti-1407	155	7	mitotic	mitotic	ADJ
dti-1407	155	8	events	event	NOUN
dti-1407	155	9	such	such	ADJ
dti-1407	155	10	as	as	ADP
dti-1407	155	11	chromosome	chromosome	NOUN
dti-1407	155	12	congression	congression	NOUN
dti-1407	155	13	and	and	CCONJ
dti-1407	155	14	chromosome	chromosome	NOUN
dti-1407	155	15	segregation	segregation	NOUN
dti-1407	155	16	.	.	PUNCT
dti-1407	156	1	two	two	NUM
dti-1407	156	2	stages	stage	NOUN
dti-1407	156	3	of	of	ADP
dti-1407	156	4	the	the	DET
dti-1407	156	5	mitotic	mitotic	ADJ
dti-1407	156	6	stage	stage	NOUN
dti-1407	156	7	of	of	ADP
dti-1407	156	8	the	the	DET
dti-1407	156	9	cell	cell	NOUN
dti-1407	156	10	cycle	cycle	NOUN
dti-1407	156	11	are	be	AUX
dti-1407	156	12	illustrated	illustrate	VERB
dti-1407	156	13	—	—	PUNCT
dti-1407	156	14	metaphase	metaphase	NOUN
dti-1407	156	15	and	and	CCONJ
dti-1407	156	16	anaphase	anaphase	NOUN
dti-1407	156	17	.	.	PUNCT
dti-1407	157	1	at	at	ADP
dti-1407	157	2	metaphase	metaphase	NOUN
dti-1407	157	3	,	,	PUNCT
dti-1407	157	4	the	the	DET
dti-1407	157	5	mitotic	mitotic	ADJ
dti-1407	157	6	spindle	spindle	NOUN
dti-1407	157	7	holds	hold	VERB
dti-1407	157	8	sister	sister	NOUN
dti-1407	157	9	chromatids	chromatids	PROPN
dti-1407	157	10	(	(	PUNCT
dti-1407	157	11	blue	blue	ADJ
dti-1407	157	12	)	)	PUNCT
dti-1407	157	13	together	together	ADV
dti-1407	157	14	at	at	ADP
dti-1407	157	15	the	the	DET
dti-1407	157	16	cell	cell	NOUN
dti-1407	157	17	equator	equator	NOUN
dti-1407	157	18	.	.	PUNCT
dti-1407	158	1	at	at	ADP
dti-1407	158	2	anaphase	anaphase	NOUN
dti-1407	158	3	,	,	PUNCT
dti-1407	158	4	the	the	DET
dti-1407	158	5	cell	cell	NOUN
dti-1407	158	6	elongates	elongate	VERB
dti-1407	158	7	the	the	DET
dti-1407	158	8	spindle	spindle	NOUN
dti-1407	158	9	poles	pole	NOUN
dti-1407	158	10	move	move	VERB
dti-1407	158	11	further	far	ADV
dti-1407	158	12	apart	apart	ADV
dti-1407	158	13	and	and	CCONJ
dti-1407	158	14	the	the	DET
dti-1407	158	15	sister	sister	NOUN
dti-1407	158	16	chromatids	chromatid	NOUN
dti-1407	158	17	move	move	VERB
dti-1407	158	18	toward	toward	ADP
dti-1407	158	19	the	the	DET
dti-1407	158	20	opposite	opposite	ADJ
dti-1407	158	21	poles	pole	NOUN
dti-1407	158	22	.	.	PUNCT
dti-1407	159	1	black	black	ADJ
dti-1407	159	2	arrows	arrow	NOUN
dti-1407	159	3	indicate	indicate	VERB
dti-1407	159	4	the	the	DET
dti-1407	159	5	path	path	NOUN
dti-1407	159	6	normally	normally	ADV
dti-1407	159	7	followed	follow	VERB
dti-1407	159	8	by	by	ADP
dti-1407	159	9	a	a	DET
dti-1407	159	10	cell	cell	NOUN
dti-1407	159	11	in	in	ADP
dti-1407	159	12	a	a	DET
dti-1407	159	13	cell	cell	NOUN
dti-1407	159	14	cycle	cycle	NOUN
dti-1407	159	15	.	.	PUNCT
dti-1407	160	1	when	when	SCONJ
dti-1407	160	2	the	the	DET
dti-1407	160	3	cell	cell	NOUN
dti-1407	160	4	cycle	cycle	NOUN
dti-1407	160	5	is	be	AUX
dti-1407	160	6	disrupted	disrupt	VERB
dti-1407	160	7	at	at	ADP
dti-1407	160	8	mitosis	mitosis	NOUN
dti-1407	160	9	by	by	ADP
dti-1407	160	10	tubulin	tubulin	NOUN
dti-1407	160	11	-	-	PUNCT
dti-1407	160	12	binding	bind	VERB
dti-1407	160	13	agents	agent	NOUN
dti-1407	160	14	,	,	PUNCT
dti-1407	160	15	the	the	DET
dti-1407	160	16	cell	cell	NOUN
dti-1407	160	17	is	be	AUX
dti-1407	160	18	unable	unable	ADJ
dti-1407	160	19	to	to	PART
dti-1407	160	20	complete	complete	VERB
dti-1407	160	21	mitosis	mitosis	NOUN
dti-1407	160	22	and	and	CCONJ
dti-1407	160	23	follows	follow	VERB
dti-1407	160	24	an	an	DET
dti-1407	160	25	alternative	alternative	ADJ
dti-1407	160	26	pathway	pathway	NOUN
dti-1407	160	27	(	(	PUNCT
dti-1407	160	28	red	red	ADJ
dti-1407	160	29	arrows	arrow	NOUN
dti-1407	160	30	)	)	PUNCT
dti-1407	160	31	where	where	SCONJ
dti-1407	160	32	it	it	PRON
dti-1407	160	33	undergoes	undergo	VERB
dti-1407	160	34	mitotic	mitotic	ADJ
dti-1407	160	35	arrest	arrest	NOUN
dti-1407	160	36	and	and	CCONJ
dti-1407	160	37	eventually	eventually	ADV
dti-1407	160	38	cell	cell	VERB
dti-1407	160	39	death	death	NOUN
dti-1407	160	40	.	.	PUNCT
dti-1407	161	1	all	all	DET
dti-1407	161	2	stages	stage	NOUN
dti-1407	161	3	of	of	ADP
dti-1407	161	4	mitosis	mitosis	NOUN
dti-1407	161	5	must	must	AUX
dti-1407	161	6	be	be	AUX
dti-1407	161	7	regulated	regulate	VERB
dti-1407	161	8	for	for	ADP
dti-1407	161	9	proper	proper	ADJ
dti-1407	161	10	development	development	NOUN
dti-1407	161	11	and	and	CCONJ
dti-1407	161	12	function	function	NOUN
dti-1407	161	13	of	of	ADP
dti-1407	161	14	a	a	DET
dti-1407	161	15	multicellular	multicellular	ADJ
dti-1407	161	16	organism	organism	NOUN
dti-1407	161	17	.	.	PUNCT
dti-1407	162	1	unregulated	unregulated	ADJ
dti-1407	162	2	mitosis	mitosis	NOUN
dti-1407	162	3	may	may	AUX
dti-1407	162	4	lead	lead	VERB
dti-1407	162	5	to	to	ADP
dti-1407	162	6	an	an	DET
dti-1407	162	7	overgrowth	overgrowth	NOUN
dti-1407	162	8	of	of	ADP
dti-1407	162	9	cells	cell	NOUN
dti-1407	162	10	,	,	PUNCT
dti-1407	162	11	as	as	ADP
dti-1407	162	12	in	in	ADP
dti-1407	162	13	cancer	cancer	NOUN
dti-1407	162	14	.	.	PUNCT
dti-1407	163	1	the	the	DET
dti-1407	163	2	ability	ability	NOUN
dti-1407	163	3	to	to	PART
dti-1407	163	4	carry	carry	VERB
dti-1407	163	5	out	out	ADP
dti-1407	163	6	an	an	DET
dti-1407	163	7	infinite	infinite	ADJ
dti-1407	163	8	number	number	NOUN
dti-1407	163	9	of	of	ADP
dti-1407	163	10	cell	cell	NOUN
dti-1407	163	11	divisions	division	NOUN
dti-1407	163	12	is	be	AUX
dti-1407	163	13	one	one	NUM
dti-1407	163	14	of	of	ADP
dti-1407	163	15	the	the	DET
dti-1407	163	16	hallmarks	hallmark	NOUN
dti-1407	163	17	of	of	ADP
dti-1407	163	18	cancer	cancer	NOUN
dti-1407	163	19	.	.	PUNCT
dti-1407	164	1	blockage	blockage	NOUN
dti-1407	164	2	of	of	ADP
dti-1407	164	3	any	any	DET
dti-1407	164	4	stage	stage	NOUN
dti-1407	164	5	of	of	ADP
dti-1407	164	6	mitosis	mitosis	NOUN
dti-1407	164	7	may	may	AUX
dti-1407	164	8	not	not	PART
dti-1407	164	9	allow	allow	VERB
dti-1407	164	10	the	the	DET
dti-1407	164	11	cells	cell	NOUN
dti-1407	164	12	to	to	PART
dti-1407	164	13	complete	complete	VERB
dti-1407	164	14	mitosis	mitosis	NOUN
dti-1407	164	15	,	,	PUNCT
dti-1407	164	16	resulting	result	VERB
dti-1407	164	17	in	in	ADP
dti-1407	164	18	cell	cell	NOUN
dti-1407	164	19	cycle	cycle	NOUN
dti-1407	164	20	arrest	arrest	NOUN
dti-1407	164	21	and	and	CCONJ
dti-1407	164	22	ultimately	ultimately	ADV
dti-1407	164	23	,	,	PUNCT
dti-1407	164	24	cell	cell	NOUN
dti-1407	164	25	death	death	NOUN
dti-1407	164	26	.	.	PUNCT
dti-1407	165	1	as	as	SCONJ
dti-1407	165	2	microtubule	microtubule	NOUN
dti-1407	165	3	dynamicity.24	dynamicity.24	NOUN
dti-1407	165	4	microtubule	microtubule	NOUN
dti-1407	165	5	dynamics	dynamic	NOUN
dti-1407	165	6	are	be	AUX
dti-1407	165	7	tightly	tightly	ADV
dti-1407	165	8	regulated	regulate	VERB
dti-1407	165	9	within	within	ADP
dti-1407	165	10	cells	cell	NOUN
dti-1407	165	11	,	,	PUNCT
dti-1407	165	12	through	through	ADP
dti-1407	165	13	the	the	DET
dti-1407	165	14	binding	binding	NOUN
dti-1407	165	15	of	of	ADP
dti-1407	165	16	various	various	ADJ
dti-1407	165	17	regulatory	regulatory	ADJ
dti-1407	165	18	proteins	protein	NOUN
dti-1407	165	19	,	,	PUNCT
dti-1407	165	20	expression	expression	NOUN
dti-1407	165	21	of	of	ADP
dti-1407	165	22	different	different	ADJ
dti-1407	165	23	tubulin	tubulin	NOUN
dti-1407	165	24	isotypes	isotype	NOUN
dti-1407	165	25	,	,	PUNCT
dti-1407	165	26	and	and	CCONJ
dti-1407	165	27	posttranslational	posttranslational	ADJ
dti-1407	165	28	modifications	modification	NOUN
dti-1407	165	29	of	of	ADP
dti-1407	165	30	tubulin	tubulin	NOUN
dti-1407	165	31	subunits.25,26	subunits.25,26	NOUN
dti-1407	165	32	dynamic	dynamic	ADJ
dti-1407	165	33	microtubules	microtubule	NOUN
dti-1407	165	34	have	have	VERB
dti-1407	165	35	a	a	DET
dti-1407	165	36	very	very	ADV
dti-1407	165	37	short	short	ADJ
dti-1407	165	38	half	half	ADJ
dti-1407	165	39	-	-	PUNCT
dti-1407	165	40	life	life	NOUN
dti-1407	165	41	of	of	ADP
dti-1407	165	42	a	a	DET
dti-1407	165	43	few	few	ADJ
dti-1407	165	44	minutes	minute	NOUN
dti-1407	165	45	,	,	PUNCT
dti-1407	165	46	or	or	CCONJ
dti-1407	165	47	even	even	ADV
dti-1407	165	48	seconds	second	NOUN
dti-1407	165	49	,	,	PUNCT
dti-1407	165	50	whereas	whereas	SCONJ
dti-1407	165	51	stable	stable	ADJ
dti-1407	165	52	microtubules	microtubule	NOUN
dti-1407	165	53	have	have	VERB
dti-1407	165	54	half	half	ADJ
dti-1407	165	55	-	-	PUNCT
dti-1407	165	56	lives	life	NOUN
dti-1407	165	57	of	of	ADP
dti-1407	165	58	minutes	minute	NOUN
dti-1407	165	59	to	to	ADP
dti-1407	165	60	hours.27	hours.27	PROPN
dti-1407	165	61	during	during	ADP
dti-1407	165	62	mitosis	mitosis	NOUN
dti-1407	165	63	,	,	PUNCT
dti-1407	165	64	microtubules	microtubule	NOUN
dti-1407	165	65	are	be	AUX
dti-1407	165	66	the	the	DET
dti-1407	165	67	main	main	ADJ
dti-1407	165	68	components	component	NOUN
dti-1407	165	69	of	of	ADP
dti-1407	165	70	the	the	DET
dti-1407	165	71	mitotic	mitotic	ADJ
dti-1407	165	72	spindle	spindle	NOUN
dti-1407	165	73	,	,	PUNCT
dti-1407	165	74	where	where	SCONJ
dti-1407	165	75	microtubule	microtubule	NOUN
dti-1407	165	76	dynamics	dynamic	NOUN
dti-1407	165	77	are	be	AUX
dti-1407	165	78	increased	increase	VERB
dti-1407	165	79	significantly.27,28	significantly.27,28	ADJ
dti-1407	165	80	dynamic	dynamic	ADJ
dti-1407	165	81	microtubules	microtubule	NOUN
dti-1407	165	82	are	be	AUX
dti-1407	165	83	required	require	VERB
dti-1407	165	84	for	for	ADP
dti-1407	165	85	all	all	DET
dti-1407	165	86	stages	stage	NOUN
dti-1407	165	87	of	of	ADP
dti-1407	165	88	mitosis	mitosis	NOUN
dti-1407	165	89	:	:	PUNCT
dti-1407	165	90	from	from	ADP
dti-1407	165	91	capturing	capture	VERB
dti-1407	165	92	and	and	CCONJ
dti-1407	165	93	congressing	congresse	VERB
dti-1407	165	94	chromosomes	chromosome	NOUN
dti-1407	165	95	to	to	ADP
dti-1407	165	96	the	the	DET
dti-1407	165	97	metaphase	metaphase	NOUN
dti-1407	165	98	plate,29	plate,29	NOUN
dti-1407	165	99	pulling	pull	VERB
dti-1407	165	100	chromosomes	chromosome	NOUN
dti-1407	165	101	toward	toward	ADP
dti-1407	165	102	opposite	opposite	ADJ
dti-1407	165	103	poles	pole	NOUN
dti-1407	165	104	and	and	CCONJ
dti-1407	165	105	initiating	initiate	VERB
dti-1407	165	106	anaphase,30	anaphase,30	PROPN
dti-1407	165	107	and	and	CCONJ
dti-1407	165	108	finally	finally	ADV
dti-1407	165	109	cytokinesis	cytokinesis	VERB
dti-1407	165	110	to	to	PART
dti-1407	165	111	complete	complete	VERB
dti-1407	165	112	mitosis.31,32	mitosis.31,32	NOUN
dti-1407	165	113	microtubule	microtubule	NOUN
dti-1407	165	114	-	-	PUNCT
dti-1407	165	115	binding	bind	VERB
dti-1407	165	116	compounds	compound	NOUN
dti-1407	165	117	may	may	AUX
dti-1407	165	118	either	either	CCONJ
dti-1407	165	119	stabilize	stabilize	VERB
dti-1407	165	120	microtubules	microtubule	NOUN
dti-1407	165	121	(	(	PUNCT
dti-1407	165	122	promoting	promote	VERB
dti-1407	165	123	growth	growth	NOUN
dti-1407	165	124	and	and	CCONJ
dti-1407	165	125	not	not	PART
dti-1407	165	126	supporting	support	VERB
dti-1407	165	127	shrinkage	shrinkage	NOUN
dti-1407	165	128	of	of	ADP
dti-1407	165	129	the	the	DET
dti-1407	165	130	microtubule	microtubule	NOUN
dti-1407	165	131	filament	filament	NOUN
dti-1407	165	132	)	)	PUNCT
dti-1407	165	133	or	or	CCONJ
dti-1407	165	134	destabilize	destabilize	VERB
dti-1407	165	135	microtubules	microtubule	NOUN
dti-1407	165	136	(	(	PUNCT
dti-1407	165	137	promoting	promote	VERB
dti-1407	165	138	shrinkage	shrinkage	NOUN
dti-1407	165	139	and	and	CCONJ
dti-1407	165	140	not	not	PART
dti-1407	165	141	supporting	support	VERB
dti-1407	165	142	growth	growth	NOUN
dti-1407	165	143	of	of	ADP
dti-1407	165	144	the	the	DET
dti-1407	165	145	microtubule	microtubule	NOUN
dti-1407	165	146	filament	filament	NOUN
dti-1407	165	147	)	)	PUNCT
dti-1407	165	148	.	.	PUNCT
dti-1407	166	1	any	any	DET
dti-1407	166	2	alterations	alteration	NOUN
dti-1407	166	3	in	in	ADP
dti-1407	166	4	microtubule	microtubule	NOUN
dti-1407	166	5	dynamics	dynamic	NOUN
dti-1407	166	6	will	will	AUX
dti-1407	166	7	affect	affect	VERB
dti-1407	166	8	the	the	DET
dti-1407	166	9	different	different	ADJ
dti-1407	166	10	events	event	NOUN
dti-1407	166	11	in	in	ADP
dti-1407	166	12	mitosis	mitosis	NOUN
dti-1407	166	13	.	.	PUNCT
dti-1407	167	1	for	for	ADP
dti-1407	167	2	example	example	NOUN
dti-1407	167	3	,	,	PUNCT
dti-1407	167	4	if	if	SCONJ
dti-1407	167	5	microtubule	microtubule	NOUN
dti-1407	167	6	dynamics	dynamic	NOUN
dti-1407	167	7	are	be	AUX
dti-1407	167	8	suppressed	suppress	VERB
dti-1407	167	9	,	,	PUNCT
dti-1407	167	10	chromosomes	chromosome	NOUN
dti-1407	167	11	may	may	AUX
dti-1407	167	12	not	not	PART
dti-1407	167	13	be	be	AUX
dti-1407	167	14	able	able	ADJ
dti-1407	167	15	to	to	PART
dti-1407	167	16	congress	congress	VERB
dti-1407	167	17	to	to	ADP
dti-1407	167	18	the	the	DET
dti-1407	167	19	metaphase	metaphase	NOUN
dti-1407	167	20	plate.33,34	plate.33,34	NOUN
dti-1407	167	21	the	the	DET
dti-1407	167	22	presence	presence	NOUN
dti-1407	167	23	of	of	ADP
dti-1407	167	24	a	a	DET
dti-1407	167	25	single	single	ADJ
dti-1407	167	26	uncongressed	uncongressed	ADJ
dti-1407	167	27	chromosome	chromosome	NOUN
dti-1407	167	28	is	be	AUX
dti-1407	167	29	enough	enough	ADJ
dti-1407	167	30	to	to	PART
dti-1407	167	31	induce	induce	VERB
dti-1407	167	32	mitotic	mitotic	ADJ
dti-1407	167	33	arrest.1	arrest.1	PROPN
dti-1407	167	34	accordingly	accordingly	ADV
dti-1407	167	35	,	,	PUNCT
dti-1407	167	36	altered	alter	VERB
dti-1407	167	37	microtubule	microtubule	NOUN
dti-1407	167	38	dynamics	dynamic	NOUN
dti-1407	167	39	is	be	AUX
dti-1407	167	40	among	among	ADP
dti-1407	167	41	the	the	DET
dti-1407	167	42	major	major	ADJ
dti-1407	167	43	causes	cause	NOUN
dti-1407	167	44	of	of	ADP
dti-1407	167	45	mitotic	mitotic	ADJ
dti-1407	167	46	arrest	arrest	NOUN
dti-1407	167	47	.	.	PUNCT
dti-1407	168	1	a	a	DET
dti-1407	168	2	cell	cell	NOUN
dti-1407	168	3	that	that	PRON
dti-1407	168	4	is	be	AUX
dti-1407	168	5	arrested	arrest	VERB
dti-1407	168	6	in	in	ADP
dti-1407	168	7	mitosis	mitosis	NOUN
dti-1407	168	8	for	for	ADP
dti-1407	168	9	a	a	DET
dti-1407	168	10	prolonged	prolonged	ADJ
dti-1407	168	11	time	time	NOUN
dti-1407	168	12	may	may	AUX
dti-1407	168	13	eventually	eventually	ADV
dti-1407	168	14	undergo	undergo	VERB
dti-1407	168	15	apoptosis	apoptosis	NOUN
dti-1407	168	16	,	,	PUNCT
dti-1407	168	17	or	or	CCONJ
dti-1407	168	18	programed	programed	ADJ
dti-1407	168	19	cell	cell	NOUN
dti-1407	168	20	death.35	death.35	NOUN
dti-1407	168	21	at	at	ADP
dti-1407	168	22	present	present	ADJ
dti-1407	168	23	,	,	PUNCT
dti-1407	168	24	most	most	ADJ
dti-1407	168	25	of	of	ADP
dti-1407	168	26	the	the	DET
dti-1407	168	27	drugs	drug	NOUN
dti-1407	168	28	used	use	VERB
dti-1407	168	29	to	to	PART
dti-1407	168	30	treat	treat	VERB
dti-1407	168	31	cancer	cancer	NOUN
dti-1407	168	32	target	target	NOUN
dti-1407	168	33	microtubule	microtubule	NOUN
dti-1407	168	34	dynamics	dynamic	NOUN
dti-1407	168	35	in	in	ADP
dti-1407	168	36	order	order	NOUN
dti-1407	168	37	to	to	PART
dti-1407	168	38	arrest	arrest	VERB
dti-1407	168	39	cancerous	cancerous	ADJ
dti-1407	168	40	cells	cell	NOUN
dti-1407	168	41	in	in	ADP
dti-1407	168	42	mitosis	mitosis	NOUN
dti-1407	168	43	.	.	PUNCT
dti-1407	169	1	microtubules	microtubule	NOUN
dti-1407	169	2	—	—	PUNCT
dti-1407	169	3	a	a	DET
dti-1407	169	4	potential	potential	ADJ
dti-1407	169	5	target	target	NOUN
dti-1407	169	6	for	for	ADP
dti-1407	169	7	cancer	cancer	NOUN
dti-1407	169	8	therapy	therapy	NOUN
dti-1407	169	9	unregulated	unregulated	ADJ
dti-1407	169	10	cell	cell	NOUN
dti-1407	169	11	division	division	NOUN
dti-1407	169	12	may	may	AUX
dti-1407	169	13	lead	lead	VERB
dti-1407	169	14	to	to	ADP
dti-1407	169	15	an	an	DET
dti-1407	169	16	overgrowth	overgrowth	NOUN
dti-1407	169	17	of	of	ADP
dti-1407	169	18	cells	cell	NOUN
dti-1407	169	19	,	,	PUNCT
dti-1407	169	20	as	as	ADP
dti-1407	169	21	in	in	ADP
dti-1407	169	22	cancer	cancer	NOUN
dti-1407	169	23	.	.	PUNCT
dti-1407	170	1	the	the	DET
dti-1407	170	2	ability	ability	NOUN
dti-1407	170	3	to	to	PART
dti-1407	170	4	carry	carry	VERB
dti-1407	170	5	out	out	ADP
dti-1407	170	6	an	an	DET
dti-1407	170	7	infinite	infinite	ADJ
dti-1407	170	8	number	number	NOUN
dti-1407	170	9	of	of	ADP
dti-1407	170	10	cell	cell	NOUN
dti-1407	170	11	divisions	division	NOUN
dti-1407	170	12	is	be	AUX
dti-1407	170	13	one	one	NUM
dti-1407	170	14	of	of	ADP
dti-1407	170	15	the	the	DET
dti-1407	170	16	hallmarks	hallmark	NOUN
dti-1407	170	17	of	of	ADP
dti-1407	170	18	cancer.36	cancer.36	ADJ
dti-1407	170	19	blockage	blockage	NOUN
dti-1407	170	20	of	of	ADP
dti-1407	170	21	any	any	DET
dti-1407	170	22	stage	stage	NOUN
dti-1407	170	23	of	of	ADP
dti-1407	170	24	mitosis	mitosis	NOUN
dti-1407	170	25	may	may	AUX
dti-1407	170	26	not	not	PART
dti-1407	170	27	allow	allow	VERB
dti-1407	170	28	the	the	DET
dti-1407	170	29	cells	cell	NOUN
dti-1407	170	30	to	to	PART
dti-1407	170	31	complete	complete	VERB
dti-1407	170	32	mitosis	mitosis	NOUN
dti-1407	170	33	,	,	PUNCT
dti-1407	170	34	resulting	result	VERB
dti-1407	170	35	in	in	ADP
dti-1407	170	36	cell	cell	NOUN
dti-1407	170	37	cycle	cycle	NOUN
dti-1407	170	38	arrest	arrest	NOUN
dti-1407	170	39	and	and	CCONJ
dti-1407	170	40	ultimately	ultimately	ADV
dti-1407	170	41	,	,	PUNCT
dti-1407	170	42	cell	cell	NOUN
dti-1407	170	43	death	death	NOUN
dti-1407	170	44	.	.	PUNCT
dti-1407	171	1	microtubules	microtubule	NOUN
dti-1407	171	2	represent	represent	VERB
dti-1407	171	3	the	the	DET
dti-1407	171	4	best	good	ADJ
dti-1407	171	5	and	and	CCONJ
dti-1407	171	6	most	most	ADV
dti-1407	171	7	successful	successful	ADJ
dti-1407	171	8	target	target	NOUN
dti-1407	171	9	thus	thus	ADV
dti-1407	171	10	far	far	ADV
dti-1407	171	11	http://www.la-press.com	http://www.la-press.com	X
dti-1407	171	12	http://www.la-press.com/drug-target-insights-journal-j23	http://www.la-press.com/drug-target-insights-journal-j23	PROPN
dti-1407	171	13	17drug	17drug	PROPN
dti-1407	171	14	target	target	NOUN
dti-1407	171	15	insights	insight	VERB
dti-1407	171	16	2015:9	2015:9	PRON
dti-1407	171	17	medicinal	medicinal	ADJ
dti-1407	171	18	plants	plant	NOUN
dti-1407	171	19	:	:	PUNCT
dti-1407	171	20	a	a	DET
dti-1407	171	21	potential	potential	ADJ
dti-1407	171	22	source	source	NOUN
dti-1407	171	23	of	of	ADP
dti-1407	171	24	compounds	compound	NOUN
dti-1407	171	25	for	for	ADP
dti-1407	171	26	targeting	target	VERB
dti-1407	171	27	cell	cell	NOUN
dti-1407	171	28	division	division	NOUN
dti-1407	171	29	identified	identify	VERB
dti-1407	171	30	in	in	ADP
dti-1407	171	31	cancer	cancer	NOUN
dti-1407	171	32	treatment.37–39	treatment.37–39	ADP
dti-1407	171	33	cancer	cancer	NOUN
dti-1407	171	34	cells	cell	NOUN
dti-1407	171	35	are	be	AUX
dti-1407	171	36	sensitive	sensitive	ADJ
dti-1407	171	37	to	to	AUX
dti-1407	171	38	microtubule	microtubule	VERB
dti-1407	171	39	poisons	poison	NOUN
dti-1407	171	40	that	that	PRON
dti-1407	171	41	arrest	arrest	VERB
dti-1407	171	42	cells	cell	NOUN
dti-1407	171	43	in	in	ADP
dti-1407	171	44	mitosis	mitosis	NOUN
dti-1407	171	45	because	because	SCONJ
dti-1407	171	46	they	they	PRON
dti-1407	171	47	undergo	undergo	VERB
dti-1407	171	48	mitosis	mitosis	NOUN
dti-1407	171	49	more	more	ADV
dti-1407	171	50	frequently	frequently	ADV
dti-1407	171	51	than	than	ADP
dti-1407	171	52	normal	normal	ADJ
dti-1407	171	53	cells	cell	NOUN
dti-1407	171	54	.	.	PUNCT
dti-1407	172	1	at	at	ADP
dti-1407	172	2	high	high	ADJ
dti-1407	172	3	concentrations	concentration	NOUN
dti-1407	172	4	,	,	PUNCT
dti-1407	172	5	anticancer	anticancer	NOUN
dti-1407	172	6	drugs	drug	NOUN
dti-1407	172	7	that	that	PRON
dti-1407	172	8	target	target	VERB
dti-1407	172	9	microtubules	microtubule	NOUN
dti-1407	172	10	may	may	AUX
dti-1407	172	11	act	act	VERB
dti-1407	172	12	in	in	ADP
dti-1407	172	13	one	one	NUM
dti-1407	172	14	of	of	ADP
dti-1407	172	15	the	the	DET
dti-1407	172	16	two	two	NUM
dti-1407	172	17	ways	way	NOUN
dti-1407	172	18	.	.	PUNCT
dti-1407	173	1	each	each	DET
dti-1407	173	2	approach	approach	NOUN
dti-1407	173	3	has	have	VERB
dti-1407	173	4	different	different	ADJ
dti-1407	173	5	effects	effect	NOUN
dti-1407	173	6	,	,	PUNCT
dti-1407	173	7	including	include	VERB
dti-1407	173	8	affecting	affect	VERB
dti-1407	173	9	the	the	DET
dti-1407	173	10	polymerized	polymerized	ADJ
dti-1407	173	11	microtubule	microtubule	NOUN
dti-1407	173	12	mass	mass	NOUN
dti-1407	173	13	,	,	PUNCT
dti-1407	173	14	destabilization	destabilization	NOUN
dti-1407	173	15	of	of	ADP
dti-1407	173	16	microtubules	microtubule	NOUN
dti-1407	173	17	(	(	PUNCT
dti-1407	173	18	decreases	decrease	VERB
dti-1407	173	19	microtubule	microtubule	NOUN
dti-1407	173	20	mass	mass	PROPN
dti-1407	173	21	)	)	PUNCT
dti-1407	173	22	,	,	PUNCT
dti-1407	173	23	and	and	CCONJ
dti-1407	173	24	stabilization	stabilization	NOUN
dti-1407	173	25	of	of	ADP
dti-1407	173	26	microtubules	microtubule	NOUN
dti-1407	173	27	(	(	PUNCT
dti-1407	173	28	increases	increase	NOUN
dti-1407	173	29	microtubule	microtubule	VERB
dti-1407	173	30	mass	mass	PROPN
dti-1407	173	31	)	)	PUNCT
dti-1407	173	32	,	,	PUNCT
dti-1407	173	33	dependent	dependent	ADJ
dti-1407	173	34	on	on	ADP
dti-1407	173	35	the	the	DET
dti-1407	173	36	site	site	NOUN
dti-1407	173	37	of	of	ADP
dti-1407	173	38	binding	bind	VERB
dti-1407	173	39	on	on	ADP
dti-1407	173	40	the	the	DET
dti-1407	173	41	microtubule	microtubule	NOUN
dti-1407	173	42	lattice.40	lattice.40	PROPN
dti-1407	173	43	the	the	DET
dti-1407	173	44	effects	effect	NOUN
dti-1407	173	45	of	of	ADP
dti-1407	173	46	each	each	DET
dti-1407	173	47	compound	compound	NOUN
dti-1407	173	48	on	on	ADP
dti-1407	173	49	microtubules	microtubule	NOUN
dti-1407	173	50	are	be	AUX
dti-1407	173	51	indicated	indicate	VERB
dti-1407	173	52	in	in	ADP
dti-1407	173	53	both	both	DET
dti-1407	173	54	tables	table	NOUN
dti-1407	173	55	1	1	NUM
dti-1407	173	56	and	and	CCONJ
dti-1407	173	57	2	2	NUM
dti-1407	173	58	.	.	PUNCT
dti-1407	173	59	currently	currently	ADV
dti-1407	173	60	,	,	PUNCT
dti-1407	173	61	there	there	PRON
dti-1407	173	62	are	be	VERB
dti-1407	173	63	two	two	NUM
dti-1407	173	64	main	main	ADJ
dti-1407	173	65	classes	class	NOUN
dti-1407	173	66	of	of	ADP
dti-1407	173	67	microtubulebinding	microtubulebinding	NOUN
dti-1407	173	68	anticancer	anticancer	NOUN
dti-1407	173	69	drugs	drug	NOUN
dti-1407	173	70	.	.	PUNCT
dti-1407	174	1	these	these	PRON
dti-1407	174	2	are	be	AUX
dti-1407	174	3	the	the	DET
dti-1407	174	4	microtubule	microtubule	NOUN
dti-1407	174	5	destabilizers	destabilizer	NOUN
dti-1407	174	6	,	,	PUNCT
dti-1407	174	7	such	such	ADJ
dti-1407	174	8	as	as	ADP
dti-1407	174	9	the	the	DET
dti-1407	174	10	vinca	vinca	NOUN
dti-1407	174	11	alkaloids,41–44	alkaloids,41–44	NOUN
dti-1407	174	12	and	and	CCONJ
dti-1407	174	13	microtubule	microtubule	NOUN
dti-1407	174	14	stabilizers	stabilizer	NOUN
dti-1407	174	15	that	that	PRON
dti-1407	174	16	prevent	prevent	VERB
dti-1407	174	17	microtubule	microtubule	NOUN
dti-1407	174	18	disassembly	disassembly	ADV
dti-1407	174	19	without	without	ADP
dti-1407	174	20	affecting	affect	VERB
dti-1407	174	21	their	their	PRON
dti-1407	174	22	polymerization	polymerization	NOUN
dti-1407	174	23	,	,	PUNCT
dti-1407	174	24	such	such	ADJ
dti-1407	174	25	as	as	ADP
dti-1407	174	26	the	the	DET
dti-1407	174	27	taxanes.6	taxanes.6	NOUN
dti-1407	174	28	however	however	ADV
dti-1407	174	29	,	,	PUNCT
dti-1407	174	30	studies	study	NOUN
dti-1407	174	31	have	have	AUX
dti-1407	174	32	shown	show	VERB
dti-1407	174	33	that	that	SCONJ
dti-1407	174	34	various	various	ADJ
dti-1407	174	35	microtubule	microtubule	NOUN
dti-1407	174	36	-	-	PUNCT
dti-1407	174	37	targeting	target	VERB
dti-1407	174	38	drugs	drug	NOUN
dti-1407	174	39	,	,	PUNCT
dti-1407	174	40	irrespective	irrespective	ADV
dti-1407	174	41	of	of	ADP
dti-1407	174	42	their	their	PRON
dti-1407	174	43	effects	effect	NOUN
dti-1407	174	44	on	on	ADP
dti-1407	174	45	polymerized	polymerized	ADJ
dti-1407	174	46	microtubule	microtubule	NOUN
dti-1407	174	47	mass	mass	NOUN
dti-1407	174	48	at	at	ADP
dti-1407	174	49	high	high	ADJ
dti-1407	174	50	concentrations	concentration	NOUN
dti-1407	174	51	,	,	PUNCT
dti-1407	174	52	all	all	DET
dti-1407	174	53	suppress	suppress	VERB
dti-1407	174	54	microtubule	microtubule	NOUN
dti-1407	174	55	dynamics	dynamic	NOUN
dti-1407	174	56	at	at	ADP
dti-1407	174	57	lower	low	ADJ
dti-1407	174	58	concentrations	concentration	NOUN
dti-1407	174	59	,	,	PUNCT
dti-1407	174	60	ie	ie	ADV
dti-1407	174	61	,	,	PUNCT
dti-1407	174	62	prevent	prevent	VERB
dti-1407	174	63	the	the	DET
dti-1407	174	64	growth	growth	NOUN
dti-1407	174	65	or	or	CCONJ
dti-1407	174	66	shrinkage	shrinkage	NOUN
dti-1407	174	67	of	of	ADP
dti-1407	174	68	microtubules	microtubule	NOUN
dti-1407	174	69	without	without	ADP
dti-1407	174	70	changing	change	VERB
dti-1407	174	71	the	the	DET
dti-1407	174	72	microtubule	microtubule	NOUN
dti-1407	174	73	polymer	polymer	NOUN
dti-1407	174	74	mass6,8,33,34,42–45	mass6,8,33,34,42–45	PROPN
dti-1407	174	75	(	(	PUNCT
dti-1407	174	76	fig	fig	NOUN
dti-1407	174	77	.	.	PUNCT
dti-1407	175	1	2	2	NUM
dti-1407	175	2	)	)	PUNCT
dti-1407	175	3	.	.	PUNCT
dti-1407	176	1	in	in	ADP
dti-1407	176	2	this	this	DET
dti-1407	176	3	way	way	NOUN
dti-1407	176	4	,	,	PUNCT
dti-1407	176	5	changes	change	NOUN
dti-1407	176	6	in	in	ADP
dti-1407	176	7	microtubule	microtubule	NOUN
dti-1407	176	8	dynamics	dynamic	NOUN
dti-1407	176	9	can	can	AUX
dti-1407	176	10	be	be	AUX
dti-1407	176	11	used	use	VERB
dti-1407	176	12	as	as	ADP
dti-1407	176	13	an	an	DET
dti-1407	176	14	indicator	indicator	NOUN
dti-1407	176	15	of	of	ADP
dti-1407	176	16	the	the	DET
dti-1407	176	17	efficacy	efficacy	NOUN
dti-1407	176	18	of	of	ADP
dti-1407	176	19	the	the	DET
dti-1407	176	20	anticancer	anticancer	NOUN
dti-1407	176	21	activities	activity	NOUN
dti-1407	176	22	of	of	ADP
dti-1407	176	23	a	a	DET
dti-1407	176	24	naturally	naturally	ADV
dti-1407	176	25	derived	derive	VERB
dti-1407	176	26	compound	compound	NOUN
dti-1407	176	27	.	.	PUNCT
dti-1407	177	1	conversely	conversely	ADV
dti-1407	177	2	,	,	PUNCT
dti-1407	177	3	tumors	tumor	NOUN
dti-1407	177	4	can	can	AUX
dti-1407	177	5	acquire	acquire	VERB
dti-1407	177	6	resistance	resistance	NOUN
dti-1407	177	7	to	to	ADP
dti-1407	177	8	microtubuletargeting	microtubuletargete	VERB
dti-1407	177	9	drugs	drug	NOUN
dti-1407	177	10	.	.	PUNCT
dti-1407	178	1	although	although	SCONJ
dti-1407	178	2	a	a	DET
dti-1407	178	3	discussion	discussion	NOUN
dti-1407	178	4	on	on	ADP
dti-1407	178	5	the	the	DET
dti-1407	178	6	resistance	resistance	NOUN
dti-1407	178	7	mechanisms	mechanism	NOUN
dti-1407	178	8	to	to	ADP
dti-1407	178	9	these	these	DET
dti-1407	178	10	drugs	drug	NOUN
dti-1407	178	11	is	be	AUX
dti-1407	178	12	beyond	beyond	ADP
dti-1407	178	13	the	the	DET
dti-1407	178	14	scope	scope	NOUN
dti-1407	178	15	of	of	ADP
dti-1407	178	16	this	this	DET
dti-1407	178	17	review	review	NOUN
dti-1407	178	18	,	,	PUNCT
dti-1407	178	19	the	the	DET
dti-1407	178	20	possible	possible	ADJ
dti-1407	178	21	methods	method	NOUN
dti-1407	178	22	of	of	ADP
dti-1407	178	23	resistance	resistance	NOUN
dti-1407	178	24	include	include	VERB
dti-1407	178	25	multidrug	multidrug	NOUN
dti-1407	178	26	resistance	resistance	NOUN
dti-1407	178	27	pumps	pump	NOUN
dti-1407	178	28	,	,	PUNCT
dti-1407	178	29	altered	alter	VERB
dti-1407	178	30	drug	drug	NOUN
dti-1407	178	31	binding	bind	VERB
dti-1407	178	32	,	,	PUNCT
dti-1407	178	33	altered	alter	VERB
dti-1407	178	34	microtubule	microtubule	NOUN
dti-1407	178	35	assembly	assembly	NOUN
dti-1407	178	36	,	,	PUNCT
dti-1407	178	37	altered	alter	VERB
dti-1407	178	38	tubulin	tubulin	NOUN
dti-1407	178	39	synthesis	synthesis	NOUN
dti-1407	178	40	,	,	PUNCT
dti-1407	178	41	and	and	CCONJ
dti-1407	178	42	alterations	alteration	NOUN
dti-1407	178	43	in	in	ADP
dti-1407	178	44	microtubuleinteracting	microtubuleinteracte	VERB
dti-1407	178	45	proteins	protein	NOUN
dti-1407	178	46	(	(	PUNCT
dti-1407	178	47	refer	refer	VERB
dti-1407	178	48	to	to	ADP
dti-1407	178	49	fojo	fojo	NOUN
dti-1407	178	50	and	and	CCONJ
dti-1407	178	51	menefee46	menefee46	NOUN
dti-1407	178	52	for	for	ADP
dti-1407	178	53	a	a	DET
dti-1407	178	54	more	more	ADV
dti-1407	178	55	extensive	extensive	ADJ
dti-1407	178	56	review	review	NOUN
dti-1407	178	57	)	)	PUNCT
dti-1407	178	58	.	.	PUNCT
dti-1407	179	1	as	as	ADP
dti-1407	179	2	with	with	ADP
dti-1407	179	3	all	all	DET
dti-1407	179	4	drugs	drug	NOUN
dti-1407	179	5	,	,	PUNCT
dti-1407	179	6	the	the	DET
dti-1407	179	7	toxic	toxic	ADJ
dti-1407	179	8	side	side	NOUN
dti-1407	179	9	effects	effect	NOUN
dti-1407	179	10	of	of	ADP
dti-1407	179	11	microtubule	microtubule	NOUN
dti-1407	179	12	-	-	PUNCT
dti-1407	179	13	targeting	target	VERB
dti-1407	179	14	agents	agent	NOUN
dti-1407	179	15	must	must	AUX
dti-1407	179	16	be	be	AUX
dti-1407	179	17	taken	take	VERB
dti-1407	179	18	into	into	ADP
dti-1407	179	19	account	account	NOUN
dti-1407	179	20	.	.	PUNCT
dti-1407	180	1	owing	owe	VERB
dti-1407	180	2	to	to	ADP
dti-1407	180	3	the	the	DET
dti-1407	180	4	physiological	physiological	ADJ
dti-1407	180	5	functions	function	NOUN
dti-1407	180	6	of	of	ADP
dti-1407	180	7	microtubules	microtubule	NOUN
dti-1407	180	8	,	,	PUNCT
dti-1407	180	9	treatment	treatment	NOUN
dti-1407	180	10	with	with	ADP
dti-1407	180	11	microtubule	microtubule	NOUN
dti-1407	180	12	-	-	PUNCT
dti-1407	180	13	targeting	target	VERB
dti-1407	180	14	agents	agent	NOUN
dti-1407	180	15	often	often	ADV
dti-1407	180	16	exhibits	exhibit	VERB
dti-1407	180	17	myelosuppression	myelosuppression	NOUN
dti-1407	180	18	and	and	CCONJ
dti-1407	180	19	peripheral	peripheral	ADJ
dti-1407	180	20	neuropathy	neuropathy	ADJ
dti-1407	180	21	.	.	PUNCT
dti-1407	181	1	the	the	DET
dti-1407	181	2	specificity	specificity	NOUN
dti-1407	181	3	of	of	ADP
dti-1407	181	4	each	each	DET
dti-1407	181	5	compound	compound	NOUN
dti-1407	181	6	must	must	AUX
dti-1407	181	7	therefore	therefore	ADV
dti-1407	181	8	be	be	AUX
dti-1407	181	9	tested	test	VERB
dti-1407	181	10	.	.	PUNCT
dti-1407	182	1	the	the	DET
dti-1407	182	2	cancers	cancer	NOUN
dti-1407	182	3	identified	identify	VERB
dti-1407	182	4	to	to	PART
dti-1407	182	5	be	be	AUX
dti-1407	182	6	susceptible	susceptible	ADJ
dti-1407	182	7	to	to	ADP
dti-1407	182	8	each	each	DET
dti-1407	182	9	drug	drug	NOUN
dti-1407	182	10	are	be	AUX
dti-1407	182	11	illustrated	illustrate	VERB
dti-1407	182	12	in	in	ADP
dti-1407	182	13	tables	table	NOUN
dti-1407	182	14	1	1	NUM
dti-1407	182	15	and	and	CCONJ
dti-1407	182	16	2	2	NUM
dti-1407	182	17	.	.	X
dti-1407	182	18	conclusion	conclusion	NOUN
dti-1407	182	19	mitosis	mitosis	NOUN
dti-1407	182	20	is	be	AUX
dti-1407	182	21	an	an	DET
dti-1407	182	22	important	important	ADJ
dti-1407	182	23	stage	stage	NOUN
dti-1407	182	24	of	of	ADP
dti-1407	182	25	the	the	DET
dti-1407	182	26	cell	cell	NOUN
dti-1407	182	27	cycle	cycle	NOUN
dti-1407	182	28	,	,	PUNCT
dti-1407	182	29	which	which	PRON
dti-1407	182	30	is	be	AUX
dti-1407	182	31	deregulated	deregulate	VERB
dti-1407	182	32	in	in	ADP
dti-1407	182	33	cancer	cancer	NOUN
dti-1407	182	34	,	,	PUNCT
dti-1407	182	35	leading	lead	VERB
dti-1407	182	36	to	to	ADP
dti-1407	182	37	uncontrolled	uncontrolled	ADJ
dti-1407	182	38	cancer	cancer	NOUN
dti-1407	182	39	growth	growth	NOUN
dti-1407	182	40	.	.	PUNCT
dti-1407	183	1	an	an	DET
dti-1407	183	2	important	important	ADJ
dti-1407	183	3	facilitator	facilitator	NOUN
dti-1407	183	4	of	of	ADP
dti-1407	183	5	mitosis	mitosis	NOUN
dti-1407	183	6	is	be	AUX
dti-1407	183	7	the	the	DET
dti-1407	183	8	microtubule	microtubule	NOUN
dti-1407	183	9	cytoskeleton	cytoskeleton	NOUN
dti-1407	183	10	.	.	PUNCT
dti-1407	184	1	hence	hence	ADV
dti-1407	184	2	,	,	PUNCT
dti-1407	184	3	many	many	ADJ
dti-1407	184	4	anticancer	anticancer	NOUN
dti-1407	184	5	drugs	drug	NOUN
dti-1407	184	6	target	target	VERB
dti-1407	184	7	the	the	DET
dti-1407	184	8	microtubule	microtubule	NOUN
dti-1407	184	9	skeleton	skeleton	NOUN
dti-1407	184	10	in	in	ADP
dti-1407	184	11	order	order	NOUN
dti-1407	184	12	to	to	PART
dti-1407	184	13	arrest	arrest	VERB
dti-1407	184	14	cancer	cancer	NOUN
dti-1407	184	15	cells	cell	NOUN
dti-1407	184	16	in	in	ADP
dti-1407	184	17	mitosis	mitosis	NOUN
dti-1407	184	18	,	,	PUNCT
dti-1407	184	19	which	which	PRON
dti-1407	184	20	eventually	eventually	ADV
dti-1407	184	21	leads	lead	VERB
dti-1407	184	22	to	to	ADP
dti-1407	184	23	cell	cell	NOUN
dti-1407	184	24	death	death	NOUN
dti-1407	184	25	.	.	PUNCT
dti-1407	185	1	most	most	ADJ
dti-1407	185	2	of	of	ADP
dti-1407	185	3	these	these	DET
dti-1407	185	4	microtubuletargeting	microtubuletargete	VERB
dti-1407	185	5	drugs	drug	NOUN
dti-1407	185	6	act	act	VERB
dti-1407	185	7	by	by	ADP
dti-1407	185	8	suppressing	suppress	VERB
dti-1407	185	9	microtubule	microtubule	NOUN
dti-1407	185	10	dynamics	dynamic	NOUN
dti-1407	185	11	,	,	PUNCT
dti-1407	185	12	which	which	PRON
dti-1407	185	13	is	be	AUX
dti-1407	185	14	particularly	particularly	ADV
dti-1407	185	15	important	important	ADJ
dti-1407	185	16	for	for	ADP
dti-1407	185	17	the	the	DET
dti-1407	185	18	microtubule	microtubule	NOUN
dti-1407	185	19	function	function	NOUN
dti-1407	185	20	in	in	ADP
dti-1407	185	21	mitosis	mitosis	NOUN
dti-1407	185	22	.	.	PUNCT
dti-1407	186	1	interestingly	interestingly	ADV
dti-1407	186	2	,	,	PUNCT
dti-1407	186	3	many	many	ADJ
dti-1407	186	4	of	of	ADP
dti-1407	186	5	the	the	DET
dti-1407	186	6	microtubule	microtubule	NOUN
dti-1407	186	7	-	-	PUNCT
dti-1407	186	8	binding	bind	VERB
dti-1407	186	9	anticancer	anticancer	NOUN
dti-1407	186	10	drugs	drug	NOUN
dti-1407	186	11	are	be	AUX
dti-1407	186	12	derived	derive	VERB
dti-1407	186	13	from	from	ADP
dti-1407	186	14	natural	natural	ADJ
dti-1407	186	15	sources	source	NOUN
dti-1407	186	16	,	,	PUNCT
dti-1407	186	17	including	include	VERB
dti-1407	186	18	taxol	taxol	PROPN
dti-1407	186	19	and	and	CCONJ
dti-1407	186	20	the	the	DET
dti-1407	186	21	vinca	vinca	NOUN
dti-1407	186	22	alkaloids	alkaloid	NOUN
dti-1407	186	23	,	,	PUNCT
dti-1407	186	24	two	two	NUM
dti-1407	186	25	very	very	ADV
dti-1407	186	26	successful	successful	ADJ
dti-1407	186	27	classes	class	NOUN
dti-1407	186	28	of	of	ADP
dti-1407	186	29	anticancer	anticancer	NOUN
dti-1407	186	30	drugs	drug	NOUN
dti-1407	186	31	.	.	PUNCT
dti-1407	187	1	therefore	therefore	ADV
dti-1407	187	2	,	,	PUNCT
dti-1407	187	3	there	there	PRON
dti-1407	187	4	is	be	VERB
dti-1407	187	5	great	great	ADJ
dti-1407	187	6	potential	potential	NOUN
dti-1407	187	7	for	for	ADP
dti-1407	187	8	the	the	DET
dti-1407	187	9	isolation	isolation	NOUN
dti-1407	187	10	of	of	ADP
dti-1407	187	11	compounds	compound	NOUN
dti-1407	187	12	with	with	ADP
dti-1407	187	13	similar	similar	ADJ
dti-1407	187	14	microtubule	microtubule	NOUN
dti-1407	187	15	-	-	PUNCT
dti-1407	187	16	targeting	target	VERB
dti-1407	187	17	figure	figure	NOUN
dti-1407	187	18	2	2	NUM
dti-1407	187	19	.	.	PUNCT
dti-1407	187	20	microtubule	microtubule	VERB
dti-1407	187	21	dynamic	dynamic	ADJ
dti-1407	187	22	instability	instability	NOUN
dti-1407	187	23	.	.	PUNCT
dti-1407	188	1	the	the	DET
dti-1407	188	2	figure	figure	NOUN
dti-1407	188	3	illustrates	illustrate	VERB
dti-1407	188	4	the	the	DET
dti-1407	188	5	growth	growth	NOUN
dti-1407	188	6	and	and	CCONJ
dti-1407	188	7	shrinkage	shrinkage	NOUN
dti-1407	188	8	of	of	ADP
dti-1407	188	9	a	a	DET
dti-1407	188	10	single	single	ADJ
dti-1407	188	11	microtubule	microtubule	NOUN
dti-1407	188	12	,	,	PUNCT
dti-1407	188	13	with	with	ADP
dti-1407	188	14	each	each	DET
dti-1407	188	15	row	row	NOUN
dti-1407	188	16	representative	representative	NOUN
dti-1407	188	17	of	of	ADP
dti-1407	188	18	a	a	DET
dti-1407	188	19	single	single	ADJ
dti-1407	188	20	time	time	NOUN
dti-1407	188	21	point	point	NOUN
dti-1407	188	22	.	.	PUNCT
dti-1407	189	1	microtubules	microtubule	NOUN
dti-1407	189	2	are	be	AUX
dti-1407	189	3	composed	compose	VERB
dti-1407	189	4	of	of	ADP
dti-1407	189	5	stable	stable	ADJ
dti-1407	189	6	αβ	αβ	INTJ
dti-1407	189	7	-	-	PUNCT
dti-1407	189	8	tubulin	tubulin	NOUN
dti-1407	189	9	heterodimers	heterodimer	NOUN
dti-1407	189	10	that	that	PRON
dti-1407	189	11	are	be	AUX
dti-1407	189	12	arranged	arrange	VERB
dti-1407	189	13	in	in	ADP
dti-1407	189	14	a	a	DET
dti-1407	189	15	head	head	NOUN
dti-1407	189	16	-	-	PUNCT
dti-1407	189	17	to	to	ADP
dti-1407	189	18	-	-	PUNCT
dti-1407	189	19	tail	tail	NOUN
dti-1407	189	20	fashion	fashion	NOUN
dti-1407	189	21	,	,	PUNCT
dti-1407	189	22	forming	form	VERB
dti-1407	189	23	a	a	DET
dti-1407	189	24	polar	polar	ADJ
dti-1407	189	25	structure	structure	NOUN
dti-1407	189	26	.	.	PUNCT
dti-1407	190	1	each	each	DET
dti-1407	190	2	heterodimer	heterodimer	NOUN
dti-1407	190	3	is	be	AUX
dti-1407	190	4	illustrated	illustrate	VERB
dti-1407	190	5	as	as	ADP
dti-1407	190	6	a	a	DET
dti-1407	190	7	single	single	ADJ
dti-1407	190	8	circle	circle	NOUN
dti-1407	190	9	.	.	PUNCT
dti-1407	191	1	microtubules	microtubule	NOUN
dti-1407	191	2	therefore	therefore	ADV
dti-1407	191	3	consist	consist	VERB
dti-1407	191	4	of	of	ADP
dti-1407	191	5	two	two	NUM
dti-1407	191	6	distinct	distinct	ADJ
dti-1407	191	7	ends	end	NOUN
dti-1407	191	8	:	:	PUNCT
dti-1407	191	9	the	the	DET
dti-1407	191	10	plus	plus	CCONJ
dti-1407	191	11	(	(	PUNCT
dti-1407	191	12	+	+	ADJ
dti-1407	191	13	)	)	PUNCT
dti-1407	191	14	end	end	NOUN
dti-1407	191	15	and	and	CCONJ
dti-1407	191	16	the	the	DET
dti-1407	191	17	minus	minus	CCONJ
dti-1407	191	18	(	(	PUNCT
dti-1407	191	19	-	-	PUNCT
dti-1407	191	20	)	)	PUNCT
dti-1407	191	21	end	end	NOUN
dti-1407	191	22	.	.	PUNCT
dti-1407	192	1	in	in	ADP
dti-1407	192	2	vivo	vivo	NOUN
dti-1407	192	3	,	,	PUNCT
dti-1407	192	4	the	the	DET
dti-1407	192	5	—	—	PUNCT
dti-1407	192	6	ends	end	NOUN
dti-1407	192	7	are	be	AUX
dti-1407	192	8	anchored	anchor	VERB
dti-1407	192	9	at	at	ADP
dti-1407	192	10	the	the	DET
dti-1407	192	11	microtubule	microtubule	NOUN
dti-1407	192	12	-	-	PUNCT
dti-1407	192	13	organizing	organize	VERB
dti-1407	192	14	centers	center	NOUN
dti-1407	192	15	.	.	PUNCT
dti-1407	193	1	the	the	DET
dti-1407	193	2	+	+	NUM
dti-1407	193	3	ends	end	NOUN
dti-1407	193	4	are	be	AUX
dti-1407	193	5	more	more	ADV
dti-1407	193	6	dynamic	dynamic	ADJ
dti-1407	193	7	than	than	ADP
dti-1407	193	8	the	the	PRON
dti-1407	193	9	—	—	PUNCT
dti-1407	193	10	ends	end	NOUN
dti-1407	193	11	,	,	PUNCT
dti-1407	193	12	with	with	SCONJ
dti-1407	193	13	the	the	DET
dti-1407	193	14	microtubule	microtubule	NOUN
dti-1407	193	15	end	end	VERB
dti-1407	193	16	constantly	constantly	ADV
dti-1407	193	17	switching	switch	VERB
dti-1407	193	18	between	between	ADP
dti-1407	193	19	growth	growth	NOUN
dti-1407	193	20	and	and	CCONJ
dti-1407	193	21	shrinkage	shrinkage	NOUN
dti-1407	193	22	in	in	ADP
dti-1407	193	23	what	what	PRON
dti-1407	193	24	is	be	AUX
dti-1407	193	25	termed	term	VERB
dti-1407	193	26	dynamic	dynamic	ADJ
dti-1407	193	27	instability	instability	NOUN
dti-1407	193	28	.	.	PUNCT
dti-1407	194	1	microtubules	microtubule	NOUN
dti-1407	194	2	are	be	AUX
dti-1407	194	3	normally	normally	ADV
dti-1407	194	4	very	very	ADV
dti-1407	194	5	dynamic	dynamic	ADJ
dti-1407	194	6	(	(	PUNCT
dti-1407	194	7	top	top	NOUN
dti-1407	194	8	)	)	PUNCT
dti-1407	194	9	,	,	PUNCT
dti-1407	194	10	with	with	SCONJ
dti-1407	194	11	tubulin	tubulin	NOUN
dti-1407	194	12	subunits	subunit	NOUN
dti-1407	194	13	randomly	randomly	ADV
dti-1407	194	14	added	add	VERB
dti-1407	194	15	or	or	CCONJ
dti-1407	194	16	lost	lose	VERB
dti-1407	194	17	from	from	ADP
dti-1407	194	18	both	both	DET
dti-1407	194	19	ends	end	NOUN
dti-1407	194	20	.	.	PUNCT
dti-1407	195	1	in	in	ADP
dti-1407	195	2	vivo	vivo	NOUN
dti-1407	195	3	,	,	PUNCT
dti-1407	195	4	microtubule	microtubule	NOUN
dti-1407	195	5	elongation	elongation	NOUN
dti-1407	195	6	usually	usually	ADV
dti-1407	195	7	occurs	occur	VERB
dti-1407	195	8	in	in	ADP
dti-1407	195	9	the	the	DET
dti-1407	195	10	plus	plus	ADJ
dti-1407	195	11	end	end	NOUN
dti-1407	195	12	.	.	PUNCT
dti-1407	196	1	when	when	SCONJ
dti-1407	196	2	microtubule	microtubule	NOUN
dti-1407	196	3	dynamics	dynamic	NOUN
dti-1407	196	4	are	be	AUX
dti-1407	196	5	suppressed	suppress	VERB
dti-1407	196	6	(	(	PUNCT
dti-1407	196	7	for	for	ADP
dti-1407	196	8	example	example	NOUN
dti-1407	196	9	,	,	PUNCT
dti-1407	196	10	through	through	ADP
dti-1407	196	11	the	the	DET
dti-1407	196	12	action	action	NOUN
dti-1407	196	13	of	of	ADP
dti-1407	196	14	tubulin	tubulin	NOUN
dti-1407	196	15	-	-	PUNCT
dti-1407	196	16	binding	bind	VERB
dti-1407	196	17	agents	agent	NOUN
dti-1407	196	18	)	)	PUNCT
dti-1407	196	19	(	(	PUNCT
dti-1407	196	20	bottom	bottom	NOUN
dti-1407	196	21	)	)	PUNCT
dti-1407	196	22	,	,	PUNCT
dti-1407	196	23	tubulin	tubulin	NOUN
dti-1407	196	24	subunits	subunit	NOUN
dti-1407	196	25	are	be	AUX
dti-1407	196	26	rarely	rarely	ADV
dti-1407	196	27	added	add	VERB
dti-1407	196	28	or	or	CCONJ
dti-1407	196	29	lost	lose	VERB
dti-1407	196	30	from	from	ADP
dti-1407	196	31	the	the	DET
dti-1407	196	32	microtubule	microtubule	NOUN
dti-1407	196	33	ends	end	VERB
dti-1407	196	34	.	.	PUNCT
dti-1407	197	1	activities	activity	NOUN
dti-1407	197	2	from	from	ADP
dti-1407	197	3	medicinal	medicinal	ADJ
dti-1407	197	4	plants	plant	NOUN
dti-1407	197	5	.	.	PUNCT
dti-1407	198	1	future	future	ADJ
dti-1407	198	2	aims	aim	VERB
dti-1407	198	3	for	for	ADP
dti-1407	198	4	the	the	DET
dti-1407	198	5	development	development	NOUN
dti-1407	198	6	of	of	ADP
dti-1407	198	7	novel	novel	ADJ
dti-1407	198	8	microtubule	microtubule	NOUN
dti-1407	198	9	-	-	PUNCT
dti-1407	198	10	binding	bind	VERB
dti-1407	198	11	agents	agent	NOUN
dti-1407	198	12	are	be	AUX
dti-1407	198	13	the	the	DET
dti-1407	198	14	development	development	NOUN
dti-1407	198	15	of	of	ADP
dti-1407	198	16	compounds	compound	NOUN
dti-1407	198	17	specific	specific	ADJ
dti-1407	198	18	to	to	ADP
dti-1407	198	19	cancer	cancer	NOUN
dti-1407	198	20	cells	cell	NOUN
dti-1407	198	21	,	,	PUNCT
dti-1407	198	22	thereby	thereby	ADV
dti-1407	198	23	reducing	reduce	VERB
dti-1407	198	24	potential	potential	ADJ
dti-1407	198	25	toxic	toxic	ADJ
dti-1407	198	26	side	side	NOUN
dti-1407	198	27	effects	effect	NOUN
dti-1407	198	28	,	,	PUNCT
dti-1407	198	29	as	as	ADV
dti-1407	198	30	well	well	ADV
dti-1407	198	31	as	as	ADP
dti-1407	198	32	the	the	DET
dti-1407	198	33	development	development	NOUN
dti-1407	198	34	of	of	ADP
dti-1407	198	35	compounds	compound	NOUN
dti-1407	198	36	that	that	PRON
dti-1407	198	37	are	be	AUX
dti-1407	198	38	able	able	ADJ
dti-1407	198	39	to	to	PART
dti-1407	198	40	overcome	overcome	VERB
dti-1407	198	41	current	current	ADJ
dti-1407	198	42	drug	drug	NOUN
dti-1407	198	43	-	-	PUNCT
dti-1407	198	44	resistant	resistant	ADJ
dti-1407	198	45	cancers	cancer	NOUN
dti-1407	198	46	.	.	PUNCT
dti-1407	199	1	author	author	NOUN
dti-1407	199	2	contributions	contribution	NOUN
dti-1407	199	3	prepared	prepare	VERB
dti-1407	199	4	the	the	DET
dti-1407	199	5	first	first	ADJ
dti-1407	199	6	draft	draft	NOUN
dti-1407	199	7	of	of	ADP
dti-1407	199	8	the	the	DET
dti-1407	199	9	manuscript	manuscript	NOUN
dti-1407	199	10	:	:	PUNCT
dti-1407	199	11	inz	inz	PROPN
dti-1407	199	12	.	.	PROPN
dti-1407	200	1	contributed	contribute	VERB
dti-1407	200	2	to	to	ADP
dti-1407	200	3	the	the	DET
dti-1407	200	4	writing	writing	NOUN
dti-1407	200	5	of	of	ADP
dti-1407	200	6	the	the	DET
dti-1407	200	7	manuscript	manuscript	NOUN
dti-1407	200	8	:	:	PUNCT
dti-1407	200	9	srd	srd	NOUN
dti-1407	200	10	,	,	PUNCT
dti-1407	200	11	rr	rr	NOUN
dti-1407	200	12	,	,	PUNCT
dti-1407	200	13	and	and	CCONJ
dti-1407	200	14	ai	ai	VERB
dti-1407	200	15	.	.	PROPN
dti-1407	201	1	jointly	jointly	ADV
dti-1407	201	2	developed	develop	VERB
dti-1407	201	3	the	the	DET
dti-1407	201	4	structure	structure	NOUN
dti-1407	201	5	and	and	CCONJ
dti-1407	201	6	arguments	argument	NOUN
dti-1407	201	7	for	for	ADP
dti-1407	201	8	the	the	DET
dti-1407	201	9	paper	paper	NOUN
dti-1407	201	10	:	:	PUNCT
dti-1407	201	11	inz	inz	PROPN
dti-1407	201	12	,	,	PUNCT
dti-1407	201	13	srd	srd	NOUN
dti-1407	201	14	,	,	PUNCT
dti-1407	201	15	rr	rr	NOUN
dti-1407	201	16	,	,	PUNCT
dti-1407	201	17	and	and	CCONJ
dti-1407	201	18	ai	ai	VERB
dti-1407	201	19	.	.	PROPN
dti-1407	201	20	made	make	VERB
dti-1407	201	21	critical	critical	ADJ
dti-1407	201	22	revisions	revision	NOUN
dti-1407	201	23	and	and	CCONJ
dti-1407	201	24	approved	approve	VERB
dti-1407	201	25	the	the	DET
dti-1407	201	26	final	final	ADJ
dti-1407	201	27	version	version	NOUN
dti-1407	201	28	:	:	PUNCT
dti-1407	201	29	ai	ai	VERB
dti-1407	201	30	.	.	PUNCT
dti-1407	202	1	all	all	DET
dti-1407	202	2	the	the	DET
dti-1407	202	3	authors	author	NOUN
dti-1407	202	4	reviewed	review	VERB
dti-1407	202	5	and	and	CCONJ
dti-1407	202	6	approved	approve	VERB
dti-1407	202	7	the	the	DET
dti-1407	202	8	final	final	ADJ
dti-1407	202	9	manuscript	manuscript	NOUN
dti-1407	202	10	.	.	PUNCT
dti-1407	203	1	http://www.la-press.com/drug-target-insights-journal-j23	http://www.la-press.com/drug-target-insights-journal-j23	PROPN
dti-1407	203	2	http://www.la-press.com	http://www.la-press.com	X
dti-1407	203	3	zulkipli	zulkipli	PROPN
dti-1407	203	4	et	et	PROPN
dti-1407	203	5	al	al	PROPN
dti-1407	203	6	18	18	NUM
dti-1407	203	7	drug	drug	NOUN
dti-1407	203	8	target	target	NOUN
dti-1407	203	9	insights	insight	NOUN
dti-1407	203	10	2015:9	2015:9	NUM
dti-1407	203	11	references	reference	NOUN
dti-1407	203	12	1	1	NUM
dti-1407	203	13	.	.	PUNCT
dti-1407	204	1	newman	newman	PROPN
dti-1407	204	2	dj	dj	PROPN
dti-1407	204	3	,	,	PUNCT
dti-1407	204	4	cragg	cragg	PROPN
dti-1407	204	5	gm	gm	PROPN
dti-1407	204	6	.	.	PUNCT
dti-1407	204	7	natural	natural	ADJ
dti-1407	204	8	products	product	NOUN
dti-1407	204	9	as	as	ADP
dti-1407	204	10	sources	source	NOUN
dti-1407	204	11	of	of	ADP
dti-1407	204	12	new	new	ADJ
dti-1407	204	13	drugs	drug	NOUN
dti-1407	204	14	over	over	ADP
dti-1407	204	15	the	the	DET
dti-1407	204	16	30	30	NUM
dti-1407	204	17	years	year	NOUN
dti-1407	204	18	from	from	ADP
dti-1407	204	19	1981	1981	NUM
dti-1407	204	20	to	to	ADP
dti-1407	204	21	2010	2010	NUM
dti-1407	204	22	.	.	PUNCT
dti-1407	205	1	j	j	PROPN
dti-1407	205	2	nat	nat	PROPN
dti-1407	205	3	prod	prod	NOUN
dti-1407	205	4	.	.	PUNCT
dti-1407	206	1	2012;75(3):311–335	2012;75(3):311–335	X
dti-1407	206	2	.	.	NOUN
dti-1407	206	3	2	2	NUM
dti-1407	206	4	.	.	X
dti-1407	206	5	loong	loong	PROPN
dti-1407	206	6	hh	hh	PROPN
dti-1407	206	7	,	,	PUNCT
dti-1407	206	8	yeo	yeo	PROPN
dti-1407	206	9	w.	w.	PROPN
dti-1407	206	10	microtubule	microtubule	NOUN
dti-1407	206	11	-	-	PUNCT
dti-1407	206	12	targeting	target	VERB
dti-1407	206	13	agents	agent	NOUN
dti-1407	206	14	in	in	ADP
dti-1407	206	15	oncology	oncology	NOUN
dti-1407	206	16	and	and	CCONJ
dti-1407	206	17	therapeutic	therapeutic	ADJ
dti-1407	206	18	potential	potential	NOUN
dti-1407	206	19	in	in	ADP
dti-1407	206	20	hepatocellular	hepatocellular	ADJ
dti-1407	206	21	carcinoma	carcinoma	NOUN
dti-1407	206	22	.	.	PUNCT
dti-1407	207	1	onco	onco	NOUN
dti-1407	207	2	targets	target	NOUN
dti-1407	207	3	ther	ther	ADV
dti-1407	207	4	.	.	PUNCT
dti-1407	208	1	2014;7:575–585	2014;7:575–585	NUM
dti-1407	208	2	.	.	NOUN
dti-1407	209	1	3	3	X
dti-1407	209	2	.	.	X
dti-1407	209	3	balunas	balunas	PROPN
dti-1407	209	4	mj	mj	PROPN
dti-1407	209	5	,	,	PUNCT
dti-1407	209	6	kinghorn	kinghorn	ADJ
dti-1407	209	7	ad	ad	NOUN
dti-1407	209	8	.	.	PUNCT
dti-1407	210	1	drug	drug	NOUN
dti-1407	210	2	discovery	discovery	PROPN
dti-1407	210	3	from	from	ADP
dti-1407	210	4	medicinal	medicinal	ADJ
dti-1407	210	5	plants	plant	NOUN
dti-1407	210	6	.	.	PUNCT
dti-1407	211	1	life	life	NOUN
dti-1407	211	2	sci	sci	PROPN
dti-1407	211	3	.	.	PUNCT
dti-1407	212	1	2005;78(5):431–441	2005;78(5):431–441	NUM
dti-1407	212	2	.	.	PROPN
dti-1407	213	1	4	4	X
dti-1407	213	2	.	.	X
dti-1407	213	3	gurib	gurib	NOUN
dti-1407	213	4	-	-	PUNCT
dti-1407	213	5	fakim	fakim	NOUN
dti-1407	213	6	a.	a.	NOUN
dti-1407	213	7	medicinal	medicinal	ADJ
dti-1407	213	8	plants	plant	NOUN
dti-1407	213	9	:	:	PUNCT
dti-1407	213	10	traditions	tradition	NOUN
dti-1407	213	11	of	of	ADP
dti-1407	213	12	yesterday	yesterday	NOUN
dti-1407	213	13	and	and	CCONJ
dti-1407	213	14	drugs	drug	NOUN
dti-1407	213	15	of	of	ADP
dti-1407	213	16	tomorrow	tomorrow	NOUN
dti-1407	213	17	.	.	PUNCT
dti-1407	214	1	mol	mol	ADP
dti-1407	214	2	aspects	aspect	NOUN
dti-1407	214	3	med	me	VERB
dti-1407	214	4	.	.	PUNCT
dti-1407	215	1	2006;27(1):1–93	2006;27(1):1–93	NUM
dti-1407	215	2	.	.	X
dti-1407	216	1	5	5	NUM
dti-1407	216	2	.	.	X
dti-1407	216	3	arnal	arnal	PROPN
dti-1407	216	4	i	i	PROPN
dti-1407	216	5	,	,	PUNCT
dti-1407	216	6	wade	wade	PROPN
dti-1407	216	7	rh	rh	PROPN
dti-1407	216	8	.	.	PUNCT
dti-1407	217	1	how	how	SCONJ
dti-1407	217	2	does	do	AUX
dti-1407	217	3	taxol	taxol	NOUN
dti-1407	217	4	stabilize	stabilize	VERB
dti-1407	217	5	microtubules	microtubule	NOUN
dti-1407	217	6	?	?	PUNCT
dti-1407	218	1	curr	curr	PROPN
dti-1407	218	2	biol	biol	PROPN
dti-1407	218	3	.	.	PUNCT
dti-1407	219	1	1995;5(8	1995;5(8	NUM
dti-1407	219	2	):	):	PUNCT
dti-1407	219	3	900–908	900–908	NUM
dti-1407	219	4	.	.	PUNCT
dti-1407	220	1	6	6	NUM
dti-1407	220	2	.	.	PUNCT
dti-1407	220	3	jordan	jordan	PROPN
dti-1407	220	4	ma	ma	PROPN
dti-1407	220	5	,	,	PUNCT
dti-1407	220	6	toso	toso	PROPN
dti-1407	220	7	rj	rj	PROPN
dti-1407	220	8	,	,	PUNCT
dti-1407	220	9	thrower	thrower	NOUN
dti-1407	220	10	d	d	NOUN
dti-1407	220	11	,	,	PUNCT
dti-1407	220	12	wilson	wilson	PROPN
dti-1407	220	13	l.	l.	PROPN
dti-1407	220	14	mechanism	mechanism	NOUN
dti-1407	220	15	of	of	ADP
dti-1407	220	16	mitotic	mitotic	ADJ
dti-1407	220	17	block	block	NOUN
dti-1407	220	18	and	and	CCONJ
dti-1407	220	19	inhibition	inhibition	NOUN
dti-1407	220	20	of	of	ADP
dti-1407	220	21	cell	cell	NOUN
dti-1407	220	22	proliferation	proliferation	NOUN
dti-1407	220	23	by	by	ADP
dti-1407	220	24	taxol	taxol	PROPN
dti-1407	220	25	at	at	ADP
dti-1407	220	26	low	low	ADJ
dti-1407	220	27	concentrations	concentration	NOUN
dti-1407	220	28	.	.	PUNCT
dti-1407	221	1	proc	proc	PROPN
dti-1407	221	2	natl	natl	PROPN
dti-1407	221	3	acad	acad	PROPN
dti-1407	221	4	sci	sci	PROPN
dti-1407	221	5	u	u	PROPN
dti-1407	221	6	s	s	NOUN
dti-1407	221	7	a.	a.	NOUN
dti-1407	221	8	1993;90(20):9552–9556	1993;90(20):9552–9556	NUM
dti-1407	221	9	.	.	PUNCT
dti-1407	222	1	7	7	NUM
dti-1407	222	2	.	.	X
dti-1407	222	3	xiao	xiao	PROPN
dti-1407	222	4	h	h	PROPN
dti-1407	222	5	,	,	PUNCT
dti-1407	222	6	wang	wang	PROPN
dti-1407	222	7	h	h	PROPN
dti-1407	222	8	,	,	PUNCT
dti-1407	222	9	zhang	zhang	PROPN
dti-1407	222	10	x	x	PROPN
dti-1407	222	11	,	,	PUNCT
dti-1407	222	12	et	et	PROPN
dti-1407	222	13	al	al	PROPN
dti-1407	222	14	.	.	PROPN
dti-1407	223	1	structural	structural	ADJ
dti-1407	223	2	evidence	evidence	NOUN
dti-1407	223	3	for	for	ADP
dti-1407	223	4	cooperative	cooperative	ADJ
dti-1407	223	5	microtubule	microtubule	NOUN
dti-1407	223	6	stabilization	stabilization	NOUN
dti-1407	223	7	by	by	ADP
dti-1407	223	8	taxol	taxol	PROPN
dti-1407	223	9	and	and	CCONJ
dti-1407	223	10	the	the	DET
dti-1407	223	11	endogenous	endogenous	ADJ
dti-1407	223	12	dynamics	dynamic	NOUN
dti-1407	223	13	regulator	regulator	NOUN
dti-1407	223	14	map4	map4	NOUN
dti-1407	223	15	.	.	PUNCT
dti-1407	224	1	acs	acs	PROPN
dti-1407	224	2	chem	chem	PROPN
dti-1407	224	3	biol	biol	PROPN
dti-1407	224	4	.	.	PUNCT
dti-1407	225	1	2012;7(4):744–752	2012;7(4):744–752	NUM
dti-1407	225	2	.	.	NOUN
dti-1407	225	3	8	8	NUM
dti-1407	225	4	.	.	X
dti-1407	225	5	yvon	yvon	PROPN
dti-1407	225	6	am	am	PROPN
dti-1407	225	7	,	,	PUNCT
dti-1407	225	8	wadsworth	wadsworth	PROPN
dti-1407	225	9	p	p	NOUN
dti-1407	225	10	,	,	PUNCT
dti-1407	225	11	jordan	jordan	PROPN
dti-1407	225	12	ma	ma	PROPN
dti-1407	225	13	.	.	PROPN
dti-1407	225	14	taxol	taxol	PROPN
dti-1407	225	15	suppresses	suppress	VERB
dti-1407	225	16	dynamics	dynamic	NOUN
dti-1407	225	17	of	of	ADP
dti-1407	225	18	individual	individual	ADJ
dti-1407	225	19	microtubules	microtubule	NOUN
dti-1407	225	20	in	in	ADP
dti-1407	225	21	living	live	VERB
dti-1407	225	22	human	human	ADJ
dti-1407	225	23	tumor	tumor	NOUN
dti-1407	225	24	cells	cell	NOUN
dti-1407	225	25	.	.	PUNCT
dti-1407	226	1	mol	mol	ADP
dti-1407	226	2	biol	biol	ADJ
dti-1407	226	3	cell	cell	NOUN
dti-1407	226	4	.	.	PUNCT
dti-1407	227	1	1999;10(4):947–959	1999;10(4):947–959	X
dti-1407	227	2	.	.	NOUN
dti-1407	227	3	9	9	NUM
dti-1407	227	4	.	.	X
dti-1407	227	5	wani	wani	PROPN
dti-1407	227	6	mc	mc	PROPN
dti-1407	227	7	,	,	PUNCT
dti-1407	227	8	taylor	taylor	PROPN
dti-1407	227	9	hl	hl	PROPN
dti-1407	227	10	,	,	PUNCT
dti-1407	227	11	wall	wall	VERB
dti-1407	227	12	me	i	PRON
dti-1407	227	13	,	,	PUNCT
dti-1407	227	14	coggon	coggon	PROPN
dti-1407	227	15	p	p	X
dti-1407	227	16	,	,	PUNCT
dti-1407	227	17	mcphail	mcphail	VERB
dti-1407	227	18	at	at	ADP
dti-1407	227	19	.	.	PUNCT
dti-1407	228	1	plant	plant	NOUN
dti-1407	228	2	antitumor	antitumor	PROPN
dti-1407	228	3	agents	agent	NOUN
dti-1407	228	4	.	.	PUNCT
dti-1407	229	1	vi	vi	X
dti-1407	229	2	.	.	PUNCT
dti-1407	230	1	the	the	DET
dti-1407	230	2	isolation	isolation	NOUN
dti-1407	230	3	and	and	CCONJ
dti-1407	230	4	structure	structure	NOUN
dti-1407	230	5	of	of	ADP
dti-1407	230	6	taxol	taxol	PROPN
dti-1407	230	7	,	,	PUNCT
dti-1407	230	8	a	a	DET
dti-1407	230	9	novel	novel	ADJ
dti-1407	230	10	antileukemic	antileukemic	ADJ
dti-1407	230	11	and	and	CCONJ
dti-1407	230	12	antitumor	antitumor	PROPN
dti-1407	230	13	agent	agent	NOUN
dti-1407	230	14	from	from	ADP
dti-1407	230	15	taxus	taxus	NOUN
dti-1407	230	16	brevifolia	brevifolia	NOUN
dti-1407	230	17	.	.	PUNCT
dti-1407	231	1	j	j	PROPN
dti-1407	231	2	am	be	AUX
dti-1407	231	3	chem	chem	NOUN
dti-1407	231	4	soc	soc	NOUN
dti-1407	231	5	.	.	PUNCT
dti-1407	232	1	1971;93(9):2325–2327	1971;93(9):2325–2327	PROPN
dti-1407	232	2	.	.	PUNCT
dti-1407	233	1	10	10	NUM
dti-1407	233	2	.	.	PUNCT
dti-1407	234	1	noble	noble	ADJ
dti-1407	234	2	rl	rl	X
dti-1407	234	3	.	.	PUNCT
dti-1407	235	1	the	the	DET
dti-1407	235	2	discovery	discovery	NOUN
dti-1407	235	3	of	of	ADP
dti-1407	235	4	the	the	DET
dti-1407	235	5	vinca	vinca	NOUN
dti-1407	235	6	alkaloids	alkaloid	NOUN
dti-1407	235	7	—	—	PUNCT
dti-1407	235	8	chemotherapeutic	chemotherapeutic	ADJ
dti-1407	235	9	agents	agent	NOUN
dti-1407	235	10	against	against	ADP
dti-1407	235	11	cancer	cancer	NOUN
dti-1407	235	12	.	.	PUNCT
dti-1407	236	1	biochem	biochem	PROPN
dti-1407	236	2	cell	cell	PROPN
dti-1407	236	3	biol	biol	PROPN
dti-1407	236	4	.	.	PUNCT
dti-1407	237	1	1990;68(12):1344–1351	1990;68(12):1344–1351	NOUN
dti-1407	237	2	.	.	PUNCT
dti-1407	238	1	11	11	NUM
dti-1407	238	2	.	.	X
dti-1407	238	3	gidding	gidde	VERB
dti-1407	238	4	ce	ce	PROPN
dti-1407	238	5	,	,	PUNCT
dti-1407	238	6	kellie	kellie	PROPN
dti-1407	238	7	sj	sj	PROPN
dti-1407	238	8	,	,	PUNCT
dti-1407	238	9	kamps	kamps	PROPN
dti-1407	238	10	wa	wa	PROPN
dti-1407	238	11	,	,	PUNCT
dti-1407	238	12	de	de	PROPN
dti-1407	238	13	graaf	graaf	PROPN
dti-1407	238	14	ss	ss	PROPN
dti-1407	238	15	.	.	PROPN
dti-1407	238	16	vincristine	vincristine	PROPN
dti-1407	238	17	revisited	revisit	VERB
dti-1407	238	18	.	.	PUNCT
dti-1407	239	1	crit	crit	PROPN
dti-1407	239	2	rev	rev	VERB
dti-1407	239	3	oncol	oncol	ADJ
dti-1407	239	4	hematol	hematol	NOUN
dti-1407	239	5	.	.	PUNCT
dti-1407	240	1	1999;29(3):267–287	1999;29(3):267–287	NUM
dti-1407	240	2	.	.	X
dti-1407	241	1	12	12	NUM
dti-1407	241	2	.	.	PUNCT
dti-1407	242	1	chin	chin	PROPN
dti-1407	242	2	y	y	PROPN
dti-1407	242	3	-	-	PUNCT
dti-1407	242	4	w	w	PROPN
dti-1407	242	5	,	,	PUNCT
dti-1407	242	6	balunas	balunas	PROPN
dti-1407	242	7	mj	mj	PROPN
dti-1407	242	8	,	,	PUNCT
dti-1407	242	9	chai	chai	NOUN
dti-1407	242	10	hb	hb	PROPN
dti-1407	242	11	,	,	PUNCT
dti-1407	242	12	kinghorn	kinghorn	ADJ
dti-1407	242	13	ad	ad	NOUN
dti-1407	242	14	.	.	PUNCT
dti-1407	243	1	drug	drug	NOUN
dti-1407	243	2	discovery	discovery	PROPN
dti-1407	243	3	from	from	ADP
dti-1407	243	4	natural	natural	ADJ
dti-1407	243	5	sources	source	NOUN
dti-1407	243	6	.	.	PUNCT
dti-1407	244	1	aaps	aaps	PROPN
dti-1407	244	2	j.	j.	PROPN
dti-1407	244	3	2006;8(2):e239	2006;8(2):e239	PROPN
dti-1407	244	4	–	–	PUNCT
dti-1407	244	5	e253	e253	PROPN
dti-1407	244	6	.	.	PUNCT
dti-1407	245	1	13	13	NUM
dti-1407	245	2	.	.	X
dti-1407	246	1	lahlou	lahlou	PROPN
dti-1407	246	2	m.	m.	PROPN
dti-1407	246	3	the	the	DET
dti-1407	246	4	success	success	NOUN
dti-1407	246	5	of	of	ADP
dti-1407	246	6	natural	natural	ADJ
dti-1407	246	7	products	product	NOUN
dti-1407	246	8	in	in	ADP
dti-1407	246	9	drug	drug	NOUN
dti-1407	246	10	discovery	discovery	NOUN
dti-1407	246	11	.	.	PUNCT
dti-1407	247	1	pharmacol	pharmacol	PROPN
dti-1407	247	2	pharm	pharm	PROPN
dti-1407	247	3	.	.	PUNCT
dti-1407	248	1	2013;4(3a):17–31	2013;4(3a):17–31	NUM
dti-1407	248	2	.	.	X
dti-1407	249	1	14	14	NUM
dti-1407	249	2	.	.	PUNCT
dti-1407	250	1	cragg	cragg	PROPN
dti-1407	250	2	gm	gm	PROPN
dti-1407	250	3	,	,	PUNCT
dti-1407	250	4	boyd	boyd	PROPN
dti-1407	250	5	mr	mr	PROPN
dti-1407	250	6	,	,	PUNCT
dti-1407	250	7	cardellina	cardellina	PROPN
dti-1407	250	8	jh	jh	PROPN
dti-1407	250	9	ii	ii	PROPN
dti-1407	250	10	,	,	PUNCT
dti-1407	250	11	newman	newman	PROPN
dti-1407	250	12	dj	dj	PROPN
dti-1407	250	13	,	,	PUNCT
dti-1407	250	14	snader	snader	PROPN
dti-1407	250	15	km	km	PROPN
dti-1407	250	16	,	,	PUNCT
dti-1407	250	17	mccloud	mccloud	PROPN
dti-1407	250	18	tg	tg	PROPN
dti-1407	250	19	.	.	PUNCT
dti-1407	251	1	ethnobotany	ethnobotany	NOUN
dti-1407	251	2	and	and	CCONJ
dti-1407	251	3	drug	drug	NOUN
dti-1407	251	4	discovery	discovery	NOUN
dti-1407	251	5	:	:	PUNCT
dti-1407	251	6	the	the	DET
dti-1407	251	7	experience	experience	NOUN
dti-1407	251	8	of	of	ADP
dti-1407	251	9	the	the	DET
dti-1407	251	10	us	us	PROPN
dti-1407	251	11	national	national	PROPN
dti-1407	251	12	cancer	cancer	PROPN
dti-1407	251	13	institute	institute	PROPN
dti-1407	251	14	.	.	PUNCT
dti-1407	252	1	ciba	ciba	PROPN
dti-1407	252	2	found	find	VERB
dti-1407	252	3	symp	symp	PROPN
dti-1407	252	4	.	.	PUNCT
dti-1407	253	1	1994;185:178–190	1994;185:178–190	NUM
dti-1407	253	2	.	.	PUNCT
dti-1407	254	1	[	[	X
dti-1407	254	2	discussion	discussion	NOUN
dti-1407	254	3	176–190	176–190	NUM
dti-1407	254	4	]	]	PUNCT
dti-1407	254	5	.	.	PUNCT
dti-1407	255	1	15	15	NUM
dti-1407	255	2	.	.	X
dti-1407	255	3	tyagi	tyagi	PROPN
dti-1407	255	4	a	a	PRON
dti-1407	255	5	,	,	PUNCT
dti-1407	255	6	prasad	prasad	PROPN
dti-1407	255	7	s.	s.	PROPN
dti-1407	255	8	drug	drug	PROPN
dti-1407	255	9	discovery	discovery	PROPN
dti-1407	255	10	inspired	inspire	VERB
dti-1407	255	11	by	by	ADP
dti-1407	255	12	mother	mother	NOUN
dti-1407	255	13	nature	nature	NOUN
dti-1407	255	14	for	for	ADP
dti-1407	255	15	cancer	cancer	NOUN
dti-1407	255	16	therapy	therapy	NOUN
dti-1407	255	17	.	.	PUNCT
dti-1407	256	1	biochem	biochem	PROPN
dti-1407	256	2	physiol	physiol	PROPN
dti-1407	256	3	.	.	PUNCT
dti-1407	257	1	2015;4	2015;4	NUM
dti-1407	257	2	:	:	PUNCT
dti-1407	257	3	e128	e128	NUM
dti-1407	257	4	.	.	PUNCT
dti-1407	258	1	16	16	NUM
dti-1407	258	2	.	.	PUNCT
dti-1407	259	1	hoelder	hoelder	PROPN
dti-1407	259	2	s	s	PROPN
dti-1407	259	3	,	,	PUNCT
dti-1407	259	4	clarke	clarke	PROPN
dti-1407	259	5	pa	pa	PROPN
dti-1407	259	6	,	,	PUNCT
dti-1407	259	7	workman	workman	NOUN
dti-1407	259	8	p.	p.	NOUN
dti-1407	259	9	discovery	discovery	NOUN
dti-1407	259	10	of	of	ADP
dti-1407	259	11	small	small	ADJ
dti-1407	259	12	molecule	molecule	NOUN
dti-1407	259	13	cancer	cancer	NOUN
dti-1407	259	14	drugs	drug	NOUN
dti-1407	259	15	:	:	PUNCT
dti-1407	259	16	successes	success	NOUN
dti-1407	259	17	,	,	PUNCT
dti-1407	259	18	challenges	challenge	NOUN
dti-1407	259	19	and	and	CCONJ
dti-1407	259	20	opportunities	opportunity	NOUN
dti-1407	259	21	.	.	PUNCT
dti-1407	260	1	mol	mol	ADP
dti-1407	260	2	oncol	oncol	ADJ
dti-1407	260	3	.	.	PUNCT
dti-1407	261	1	2012;6(2):155–176	2012;6(2):155–176	NUM
dti-1407	261	2	.	.	NOUN
dti-1407	262	1	17	17	NUM
dti-1407	262	2	.	.	PUNCT
dti-1407	263	1	downing	down	VERB
dti-1407	263	2	kh	kh	PROPN
dti-1407	263	3	,	,	PUNCT
dti-1407	263	4	nogales	nogales	PROPN
dti-1407	263	5	e.	e.	PROPN
dti-1407	263	6	tubulin	tubulin	PROPN
dti-1407	263	7	structure	structure	NOUN
dti-1407	263	8	:	:	PUNCT
dti-1407	263	9	insights	insight	NOUN
dti-1407	263	10	into	into	ADP
dti-1407	263	11	microtubule	microtubule	NOUN
dti-1407	263	12	properties	property	NOUN
dti-1407	263	13	and	and	CCONJ
dti-1407	263	14	functions	function	NOUN
dti-1407	263	15	.	.	PUNCT
dti-1407	264	1	curr	curr	PROPN
dti-1407	264	2	opin	opin	PROPN
dti-1407	264	3	struct	struct	NOUN
dti-1407	264	4	biol	biol	NOUN
dti-1407	264	5	.	.	PUNCT
dti-1407	265	1	1998;8(6):785–791	1998;8(6):785–791	NUM
dti-1407	265	2	.	.	NOUN
dti-1407	265	3	18	18	NUM
dti-1407	265	4	.	.	PUNCT
dti-1407	265	5	mogilner	mogilner	VERB
dti-1407	265	6	a	a	PRON
dti-1407	265	7	,	,	PUNCT
dti-1407	265	8	keren	keren	PROPN
dti-1407	265	9	k.	k.	PROPN
dti-1407	266	1	the	the	DET
dti-1407	266	2	shape	shape	NOUN
dti-1407	266	3	of	of	ADP
dti-1407	266	4	motile	motile	ADJ
dti-1407	266	5	cells	cell	NOUN
dti-1407	266	6	.	.	PUNCT
dti-1407	267	1	curr	curr	PROPN
dti-1407	267	2	biol	biol	PROPN
dti-1407	267	3	.	.	PUNCT
dti-1407	268	1	2009;19(17):r762	2009;19(17):r762	NUM
dti-1407	268	2	–	–	PUNCT
dti-1407	268	3	r771	r771	PROPN
dti-1407	268	4	.	.	PROPN
dti-1407	269	1	19	19	NUM
dti-1407	269	2	.	.	PUNCT
dti-1407	269	3	vale	vale	PROPN
dti-1407	269	4	rd	rd	PROPN
dti-1407	269	5	.	.	PUNCT
dti-1407	269	6	intracellular	intracellular	ADJ
dti-1407	269	7	transport	transport	NOUN
dti-1407	269	8	using	use	VERB
dti-1407	269	9	microtubule	microtubule	NOUN
dti-1407	269	10	-	-	PUNCT
dti-1407	269	11	based	base	VERB
dti-1407	269	12	motors	motor	NOUN
dti-1407	269	13	.	.	PUNCT
dti-1407	270	1	annu	annu	PROPN
dti-1407	270	2	rev	rev	VERB
dti-1407	270	3	cell	cell	NOUN
dti-1407	270	4	biol	biol	NOUN
dti-1407	270	5	.	.	PUNCT
dti-1407	271	1	1987;3:347–378	1987;3:347–378	NUM
dti-1407	271	2	.	.	NOUN
dti-1407	271	3	20	20	NUM
dti-1407	271	4	.	.	PUNCT
dti-1407	271	5	ridley	ridley	PROPN
dti-1407	271	6	aj	aj	PROPN
dti-1407	271	7	,	,	PUNCT
dti-1407	271	8	schwartz	schwartz	PROPN
dti-1407	271	9	ma	ma	PROPN
dti-1407	271	10	,	,	PUNCT
dti-1407	271	11	burridge	burridge	PROPN
dti-1407	271	12	k	k	PROPN
dti-1407	271	13	,	,	PUNCT
dti-1407	271	14	et	et	PROPN
dti-1407	271	15	al	al	PROPN
dti-1407	271	16	.	.	PROPN
dti-1407	271	17	cell	cell	NOUN
dti-1407	271	18	migration	migration	NOUN
dti-1407	271	19	:	:	PUNCT
dti-1407	271	20	integrating	integrate	VERB
dti-1407	271	21	signals	signal	NOUN
dti-1407	271	22	from	from	ADP
dti-1407	271	23	front	front	NOUN
dti-1407	271	24	to	to	ADP
dti-1407	271	25	back	back	NOUN
dti-1407	271	26	.	.	PUNCT
dti-1407	272	1	science	science	NOUN
dti-1407	272	2	.	.	PUNCT
dti-1407	273	1	2003;302(5651):1704–1709	2003;302(5651):1704–1709	NUM
dti-1407	273	2	.	.	PUNCT
dti-1407	274	1	21	21	NUM
dti-1407	274	2	.	.	PUNCT
dti-1407	275	1	stehbens	stehbens	PROPN
dti-1407	275	2	s	s	PROPN
dti-1407	275	3	,	,	PUNCT
dti-1407	275	4	wittmann	wittmann	PROPN
dti-1407	275	5	t.	t.	PROPN
dti-1407	275	6	targeting	targeting	NOUN
dti-1407	275	7	and	and	CCONJ
dti-1407	275	8	transport	transport	NOUN
dti-1407	275	9	:	:	PUNCT
dti-1407	275	10	how	how	SCONJ
dti-1407	275	11	microtubules	microtubule	NOUN
dti-1407	275	12	control	control	VERB
dti-1407	275	13	focal	focal	ADJ
dti-1407	275	14	adhesion	adhesion	NOUN
dti-1407	275	15	dynamics	dynamic	NOUN
dti-1407	275	16	.	.	PUNCT
dti-1407	276	1	j	j	PROPN
dti-1407	276	2	cell	cell	PROPN
dti-1407	276	3	biol	biol	PROPN
dti-1407	276	4	.	.	PUNCT
dti-1407	277	1	2012;198(4):481–489	2012;198(4):481–489	X
dti-1407	277	2	.	.	PUNCT
dti-1407	278	1	22	22	NUM
dti-1407	278	2	.	.	PUNCT
dti-1407	279	1	gundersen	gundersen	PROPN
dti-1407	279	2	gg	gg	PROPN
dti-1407	279	3	,	,	PUNCT
dti-1407	279	4	cook	cook	VERB
dti-1407	279	5	ta	ta	PROPN
dti-1407	279	6	.	.	PUNCT
dti-1407	280	1	microtubules	microtubule	NOUN
dti-1407	280	2	and	and	CCONJ
dti-1407	280	3	signal	signal	ADJ
dti-1407	280	4	transduction	transduction	NOUN
dti-1407	280	5	.	.	PUNCT
dti-1407	281	1	curr	curr	PROPN
dti-1407	281	2	opin	opin	NOUN
dti-1407	281	3	cell	cell	NOUN
dti-1407	281	4	biol	biol	NOUN
dti-1407	281	5	.	.	PUNCT
dti-1407	282	1	1999;11(1):81–94	1999;11(1):81–94	X
dti-1407	282	2	.	.	NOUN
dti-1407	282	3	23	23	NUM
dti-1407	282	4	.	.	PUNCT
dti-1407	283	1	khodjakov	khodjakov	PROPN
dti-1407	283	2	a	a	DET
dti-1407	283	3	,	,	PUNCT
dti-1407	283	4	rieder	rieder	ADJ
dti-1407	283	5	cl	cl	NOUN
dti-1407	283	6	.	.	PUNCT
dti-1407	283	7	mitosis	mitosis	NOUN
dti-1407	283	8	:	:	PUNCT
dti-1407	283	9	too	too	ADV
dti-1407	283	10	much	much	ADJ
dti-1407	283	11	of	of	ADP
dti-1407	283	12	a	a	DET
dti-1407	283	13	good	good	ADJ
dti-1407	283	14	thing	thing	NOUN
dti-1407	283	15	(	(	PUNCT
dti-1407	283	16	can	can	AUX
dti-1407	283	17	be	be	AUX
dti-1407	283	18	bad	bad	ADJ
dti-1407	283	19	)	)	PUNCT
dti-1407	283	20	.	.	PUNCT
dti-1407	284	1	curr	curr	PROPN
dti-1407	284	2	biol	biol	PROPN
dti-1407	284	3	.	.	PUNCT
dti-1407	285	1	2009;19(22):r1032	2009;19(22):r1032	X
dti-1407	285	2	–	–	PUNCT
dti-1407	285	3	r1034	r1034	NOUN
dti-1407	285	4	.	.	NOUN
dti-1407	286	1	24	24	NUM
dti-1407	286	2	.	.	PUNCT
dti-1407	286	3	mitchison	mitchison	PROPN
dti-1407	286	4	t	t	PROPN
dti-1407	286	5	,	,	PUNCT
dti-1407	286	6	kirschner	kirschner	PROPN
dti-1407	286	7	m.	m.	PROPN
dti-1407	286	8	dynamic	dynamic	ADJ
dti-1407	286	9	instability	instability	NOUN
dti-1407	286	10	of	of	ADP
dti-1407	286	11	microtubule	microtubule	NOUN
dti-1407	286	12	growth	growth	NOUN
dti-1407	286	13	.	.	PUNCT
dti-1407	287	1	nature	nature	NOUN
dti-1407	287	2	.	.	PUNCT
dti-1407	288	1	1984;312(5991):237–242	1984;312(5991):237–242	X
dti-1407	288	2	.	.	PUNCT
dti-1407	289	1	25	25	NUM
dti-1407	289	2	.	.	PUNCT
dti-1407	290	1	etienne	etienne	NOUN
dti-1407	290	2	-	-	PUNCT
dti-1407	290	3	manneville	manneville	PROPN
dti-1407	290	4	s.	s.	PROPN
dti-1407	290	5	from	from	ADP
dti-1407	290	6	signaling	signal	VERB
dti-1407	290	7	pathways	pathway	NOUN
dti-1407	290	8	to	to	ADP
dti-1407	290	9	microtubule	microtubule	NOUN
dti-1407	290	10	dynamics	dynamic	NOUN
dti-1407	290	11	:	:	PUNCT
dti-1407	290	12	the	the	DET
dti-1407	290	13	key	key	ADJ
dti-1407	290	14	players	player	NOUN
dti-1407	290	15	.	.	PUNCT
dti-1407	291	1	curr	curr	PROPN
dti-1407	291	2	opin	opin	NOUN
dti-1407	291	3	cell	cell	NOUN
dti-1407	291	4	biol	biol	NOUN
dti-1407	291	5	.	.	PUNCT
dti-1407	292	1	2010;22(1):104–111	2010;22(1):104–111	NUM
dti-1407	292	2	.	.	PROPN
dti-1407	292	3	26	26	NUM
dti-1407	292	4	.	.	PUNCT
dti-1407	293	1	van	van	PROPN
dti-1407	293	2	der	der	PROPN
dti-1407	293	3	vaart	vaart	PROPN
dti-1407	293	4	b	b	PROPN
dti-1407	293	5	,	,	PUNCT
dti-1407	293	6	akhmanova	akhmanova	X
dti-1407	293	7	a	a	PRON
dti-1407	293	8	,	,	PUNCT
dti-1407	293	9	straube	straube	VERB
dti-1407	293	10	a.	a.	NOUN
dti-1407	293	11	regulation	regulation	NOUN
dti-1407	293	12	of	of	ADP
dti-1407	293	13	microtubule	microtubule	NOUN
dti-1407	293	14	dynamic	dynamic	ADJ
dti-1407	293	15	instability	instability	NOUN
dti-1407	293	16	.	.	PUNCT
dti-1407	294	1	biochem	biochem	PROPN
dti-1407	294	2	soc	soc	PROPN
dti-1407	294	3	trans	trans	PROPN
dti-1407	294	4	.	.	PUNCT
dti-1407	295	1	2009;37(pt	2009;37(pt	PROPN
dti-1407	295	2	5):1007–1013	5):1007–1013	NUM
dti-1407	295	3	.	.	PROPN
dti-1407	295	4	27	27	NUM
dti-1407	295	5	.	.	PUNCT
dti-1407	296	1	saxton	saxton	PROPN
dti-1407	296	2	wm	wm	PROPN
dti-1407	296	3	,	,	PUNCT
dti-1407	296	4	stemple	stemple	PROPN
dti-1407	296	5	dl	dl	PROPN
dti-1407	296	6	,	,	PUNCT
dti-1407	296	7	leslie	leslie	PROPN
dti-1407	296	8	rj	rj	PROPN
dti-1407	296	9	,	,	PUNCT
dti-1407	296	10	salmon	salmon	PROPN
dti-1407	296	11	ed	ed	NOUN
dti-1407	296	12	,	,	PUNCT
dti-1407	296	13	zavortink	zavortink	PROPN
dti-1407	296	14	m	m	PROPN
dti-1407	296	15	,	,	PUNCT
dti-1407	296	16	mcintosh	mcintosh	PROPN
dti-1407	296	17	jr	jr	PROPN
dti-1407	296	18	.	.	PROPN
dti-1407	296	19	tubulin	tubulin	NOUN
dti-1407	296	20	dynamics	dynamic	NOUN
dti-1407	296	21	in	in	ADP
dti-1407	296	22	cultured	cultured	ADJ
dti-1407	296	23	mammalian	mammalian	ADJ
dti-1407	296	24	cells	cell	NOUN
dti-1407	296	25	.	.	PUNCT
dti-1407	297	1	j	j	PROPN
dti-1407	297	2	cell	cell	NOUN
dti-1407	297	3	biol	biol	PROPN
dti-1407	297	4	.	.	PUNCT
dti-1407	298	1	1984;99(6):2175–2186	1984;99(6):2175–2186	NUM
dti-1407	298	2	.	.	PUNCT
dti-1407	299	1	28	28	NUM
dti-1407	299	2	.	.	PUNCT
dti-1407	300	1	salmon	salmon	PROPN
dti-1407	300	2	ed	ed	PROPN
dti-1407	300	3	,	,	PUNCT
dti-1407	300	4	leslie	leslie	PROPN
dti-1407	300	5	rj	rj	PROPN
dti-1407	300	6	,	,	PUNCT
dti-1407	300	7	saxton	saxton	PROPN
dti-1407	300	8	wm	wm	PROPN
dti-1407	300	9	,	,	PUNCT
dti-1407	300	10	karow	karow	PROPN
dti-1407	300	11	ml	ml	PROPN
dti-1407	300	12	,	,	PUNCT
dti-1407	300	13	mcintosh	mcintosh	PROPN
dti-1407	300	14	jr	jr	PROPN
dti-1407	300	15	.	.	PROPN
dti-1407	300	16	spindle	spindle	NOUN
dti-1407	300	17	microtubule	microtubule	NOUN
dti-1407	300	18	dynamics	dynamic	NOUN
dti-1407	300	19	in	in	ADP
dti-1407	300	20	sea	sea	NOUN
dti-1407	300	21	urchin	urchin	NOUN
dti-1407	300	22	embryos	embryo	NOUN
dti-1407	300	23	:	:	PUNCT
dti-1407	300	24	analysis	analysis	NOUN
dti-1407	300	25	using	use	VERB
dti-1407	300	26	a	a	DET
dti-1407	300	27	fluorescein	fluorescein	NOUN
dti-1407	300	28	-	-	PUNCT
dti-1407	300	29	labeled	label	VERB
dti-1407	300	30	tubulin	tubulin	NOUN
dti-1407	300	31	and	and	CCONJ
dti-1407	300	32	measurements	measurement	NOUN
dti-1407	300	33	of	of	ADP
dti-1407	300	34	fluorescence	fluorescence	ADJ
dti-1407	300	35	redistribution	redistribution	NOUN
dti-1407	300	36	after	after	ADP
dti-1407	300	37	laser	laser	NOUN
dti-1407	300	38	photobleaching	photobleaching	NOUN
dti-1407	300	39	.	.	PUNCT
dti-1407	301	1	j	j	PROPN
dti-1407	301	2	cell	cell	NOUN
dti-1407	301	3	biol	biol	PROPN
dti-1407	301	4	.	.	PUNCT
dti-1407	302	1	1984;99(6):2165–2174	1984;99(6):2165–2174	NUM
dti-1407	302	2	.	.	PUNCT
dti-1407	303	1	29	29	NUM
dti-1407	303	2	.	.	PUNCT
dti-1407	303	3	kapoor	kapoor	PROPN
dti-1407	303	4	tm	tm	PROPN
dti-1407	303	5	,	,	PUNCT
dti-1407	303	6	compton	compton	PROPN
dti-1407	303	7	da	da	PROPN
dti-1407	303	8	.	.	PUNCT
dti-1407	304	1	searching	search	VERB
dti-1407	304	2	for	for	ADP
dti-1407	304	3	the	the	DET
dti-1407	304	4	middle	middle	ADJ
dti-1407	304	5	ground	ground	NOUN
dti-1407	304	6	:	:	PUNCT
dti-1407	304	7	mechanisms	mechanism	NOUN
dti-1407	304	8	of	of	ADP
dti-1407	304	9	chromosome	chromosome	NOUN
dti-1407	304	10	alignment	alignment	NOUN
dti-1407	304	11	during	during	ADP
dti-1407	304	12	mitosis	mitosis	NOUN
dti-1407	304	13	.	.	PUNCT
dti-1407	305	1	j	j	PROPN
dti-1407	305	2	cell	cell	PROPN
dti-1407	305	3	biol	biol	PROPN
dti-1407	305	4	.	.	PUNCT
dti-1407	306	1	2002;157(4):551–556	2002;157(4):551–556	X
dti-1407	306	2	.	.	NOUN
dti-1407	306	3	30	30	NUM
dti-1407	306	4	.	.	PUNCT
dti-1407	306	5	gorbsky	gorbsky	PROPN
dti-1407	306	6	gj	gj	PROPN
dti-1407	306	7	,	,	PUNCT
dti-1407	306	8	sammak	sammak	PROPN
dti-1407	306	9	pj	pj	PROPN
dti-1407	306	10	,	,	PUNCT
dti-1407	306	11	borisy	borisy	PROPN
dti-1407	306	12	gg	gg	PROPN
dti-1407	306	13	.	.	PUNCT
dti-1407	307	1	chromosomes	chromosome	NOUN
dti-1407	307	2	move	move	VERB
dti-1407	307	3	poleward	poleward	ADV
dti-1407	307	4	in	in	ADP
dti-1407	307	5	anaphase	anaphase	NOUN
dti-1407	307	6	along	along	ADP
dti-1407	307	7	stationary	stationary	ADJ
dti-1407	307	8	microtubules	microtubule	NOUN
dti-1407	307	9	that	that	PRON
dti-1407	307	10	coordinately	coordinately	ADV
dti-1407	307	11	disassemble	disassemble	ADJ
dti-1407	307	12	from	from	ADP
dti-1407	307	13	their	their	PRON
dti-1407	307	14	kinetochore	kinetochore	NOUN
dti-1407	307	15	ends	end	NOUN
dti-1407	307	16	.	.	PUNCT
dti-1407	308	1	j	j	PROPN
dti-1407	308	2	cell	cell	PROPN
dti-1407	308	3	biol	biol	PROPN
dti-1407	308	4	.	.	PUNCT
dti-1407	309	1	1987;104(1):9–18	1987;104(1):9–18	NUM
dti-1407	309	2	.	.	PUNCT
dti-1407	310	1	31	31	NUM
dti-1407	310	2	.	.	PUNCT
dti-1407	311	1	strickland	strickland	PROPN
dti-1407	311	2	li	li	PROPN
dti-1407	311	3	,	,	PUNCT
dti-1407	311	4	wen	wen	PROPN
dti-1407	311	5	y	y	PROPN
dti-1407	311	6	,	,	PUNCT
dti-1407	311	7	gundersen	gundersen	PROPN
dti-1407	311	8	gg	gg	PROPN
dti-1407	311	9	,	,	PUNCT
dti-1407	311	10	burgess	burgess	PROPN
dti-1407	311	11	dr	dr	PROPN
dti-1407	311	12	.	.	PROPN
dti-1407	311	13	interaction	interaction	NOUN
dti-1407	311	14	between	between	ADP
dti-1407	311	15	eb1	eb1	PROPN
dti-1407	311	16	and	and	CCONJ
dti-1407	311	17	p150glued	p150glue	VERB
dti-1407	311	18	is	be	AUX
dti-1407	311	19	required	require	VERB
dti-1407	311	20	for	for	ADP
dti-1407	311	21	anaphase	anaphase	NOUN
dti-1407	311	22	astral	astral	ADJ
dti-1407	311	23	microtubule	microtubule	NOUN
dti-1407	311	24	elongation	elongation	NOUN
dti-1407	311	25	and	and	CCONJ
dti-1407	311	26	stimulation	stimulation	NOUN
dti-1407	311	27	of	of	ADP
dti-1407	311	28	cytokinesis	cytokinesis	NOUN
dti-1407	311	29	.	.	PUNCT
dti-1407	312	1	curr	curr	PROPN
dti-1407	312	2	biol	biol	PROPN
dti-1407	312	3	.	.	PUNCT
dti-1407	313	1	2005;15(24):2249–2255	2005;15(24):2249–2255	NUM
dti-1407	313	2	.	.	PUNCT
dti-1407	314	1	32	32	NUM
dti-1407	314	2	.	.	PUNCT
dti-1407	315	1	ferreira	ferreira	PROPN
dti-1407	315	2	jg	jg	PROPN
dti-1407	315	3	,	,	PUNCT
dti-1407	315	4	pereira	pereira	PROPN
dti-1407	315	5	aj	aj	PROPN
dti-1407	315	6	,	,	PUNCT
dti-1407	315	7	akhmanova	akhmanova	VERB
dti-1407	315	8	a	a	PRON
dti-1407	315	9	,	,	PUNCT
dti-1407	315	10	maiato	maiato	PROPN
dti-1407	315	11	h.	h.	PROPN
dti-1407	315	12	aurora	aurora	PROPN
dti-1407	315	13	b	b	PROPN
dti-1407	315	14	spatially	spatially	ADV
dti-1407	315	15	regulates	regulate	VERB
dti-1407	315	16	eb3	eb3	ADJ
dti-1407	315	17	phosphorylation	phosphorylation	NOUN
dti-1407	315	18	to	to	PART
dti-1407	315	19	coordinate	coordinate	VERB
dti-1407	315	20	daughter	daughter	NOUN
dti-1407	315	21	cell	cell	NOUN
dti-1407	315	22	adhesion	adhesion	NOUN
dti-1407	315	23	with	with	ADP
dti-1407	315	24	cytokinesis	cytokinesis	NOUN
dti-1407	315	25	.	.	PUNCT
dti-1407	316	1	j	j	PROPN
dti-1407	316	2	cell	cell	NOUN
dti-1407	316	3	biol	biol	PROPN
dti-1407	316	4	.	.	PUNCT
dti-1407	317	1	2013;201(5):709–724	2013;201(5):709–724	X
dti-1407	317	2	.	.	PUNCT
dti-1407	318	1	33	33	NUM
dti-1407	318	2	.	.	PUNCT
dti-1407	319	1	honore	honore	PROPN
dti-1407	319	2	s	s	PROPN
dti-1407	319	3	,	,	PUNCT
dti-1407	319	4	kamath	kamath	PROPN
dti-1407	319	5	k	k	PROPN
dti-1407	319	6	,	,	PUNCT
dti-1407	319	7	braguer	braguer	PROPN
dti-1407	319	8	d	d	PROPN
dti-1407	319	9	,	,	PUNCT
dti-1407	319	10	wilson	wilson	PROPN
dti-1407	319	11	l	l	PROPN
dti-1407	319	12	,	,	PUNCT
dti-1407	319	13	briand	briand	PROPN
dti-1407	319	14	c	c	PROPN
dti-1407	319	15	,	,	PUNCT
dti-1407	319	16	jordan	jordan	PROPN
dti-1407	319	17	ma	ma	PROPN
dti-1407	319	18	.	.	PROPN
dti-1407	319	19	suppression	suppression	NOUN
dti-1407	319	20	of	of	ADP
dti-1407	319	21	microtubule	microtubule	NOUN
dti-1407	319	22	dynamics	dynamic	NOUN
dti-1407	319	23	by	by	ADP
dti-1407	319	24	discodermolide	discodermolide	NOUN
dti-1407	319	25	by	by	ADP
dti-1407	319	26	a	a	DET
dti-1407	319	27	novel	novel	ADJ
dti-1407	319	28	mechanism	mechanism	NOUN
dti-1407	319	29	is	be	AUX
dti-1407	319	30	associated	associate	VERB
dti-1407	319	31	with	with	ADP
dti-1407	319	32	mitotic	mitotic	ADJ
dti-1407	319	33	arrest	arrest	NOUN
dti-1407	319	34	and	and	CCONJ
dti-1407	319	35	inhibition	inhibition	NOUN
dti-1407	319	36	of	of	ADP
dti-1407	319	37	tumor	tumor	NOUN
dti-1407	319	38	cell	cell	NOUN
dti-1407	319	39	proliferation	proliferation	NOUN
dti-1407	319	40	.	.	PUNCT
dti-1407	320	1	mol	mol	ADP
dti-1407	320	2	cancer	cancer	NOUN
dti-1407	320	3	ther	ther	ADV
dti-1407	320	4	.	.	PUNCT
dti-1407	321	1	2003	2003	NUM
dti-1407	321	2	;	;	PUNCT
dti-1407	321	3	2(12):1303–1311	2(12):1303–1311	NUM
dti-1407	321	4	.	.	PUNCT
dti-1407	322	1	34	34	NUM
dti-1407	322	2	.	.	PUNCT
dti-1407	323	1	kamath	kamath	PROPN
dti-1407	323	2	k	k	PROPN
dti-1407	323	3	,	,	PUNCT
dti-1407	323	4	okouneva	okouneva	PROPN
dti-1407	323	5	t	t	PROPN
dti-1407	323	6	,	,	PUNCT
dti-1407	323	7	larson	larson	PROPN
dti-1407	323	8	g	g	PROPN
dti-1407	323	9	,	,	PUNCT
dti-1407	323	10	panda	panda	NOUN
dti-1407	323	11	d	d	PROPN
dti-1407	323	12	,	,	PUNCT
dti-1407	323	13	wilson	wilson	PROPN
dti-1407	323	14	l	l	PROPN
dti-1407	323	15	,	,	PUNCT
dti-1407	323	16	jordan	jordan	PROPN
dti-1407	323	17	ma	ma	PROPN
dti-1407	323	18	.	.	PROPN
dti-1407	323	19	2	2	NUM
dti-1407	323	20	-	-	PUNCT
dti-1407	323	21	methoxyestradiol	methoxyestradiol	NOUN
dti-1407	323	22	suppresses	suppress	VERB
dti-1407	323	23	microtubule	microtubule	NOUN
dti-1407	323	24	dynamics	dynamic	NOUN
dti-1407	323	25	and	and	CCONJ
dti-1407	323	26	arrests	arrest	NOUN
dti-1407	323	27	mitosis	mitosis	NOUN
dti-1407	323	28	without	without	ADP
dti-1407	323	29	depolymerizing	depolymerizing	NOUN
dti-1407	323	30	microtubules	microtubule	NOUN
dti-1407	323	31	.	.	PUNCT
dti-1407	324	1	mol	mol	ADP
dti-1407	324	2	cancer	cancer	NOUN
dti-1407	324	3	ther	ther	ADV
dti-1407	324	4	.	.	PUNCT
dti-1407	325	1	2006;5(9):2225–2233	2006;5(9):2225–2233	X
dti-1407	325	2	.	.	PUNCT
dti-1407	326	1	35	35	NUM
dti-1407	326	2	.	.	PUNCT
dti-1407	327	1	gascoigne	gascoigne	PROPN
dti-1407	327	2	ke	ke	PROPN
dti-1407	327	3	,	,	PUNCT
dti-1407	327	4	taylor	taylor	PROPN
dti-1407	327	5	ss	ss	PROPN
dti-1407	327	6	.	.	PUNCT
dti-1407	328	1	how	how	SCONJ
dti-1407	328	2	do	do	AUX
dti-1407	328	3	anti	anti	ADJ
dti-1407	328	4	-	-	ADJ
dti-1407	328	5	mitotic	mitotic	ADJ
dti-1407	328	6	drugs	drug	NOUN
dti-1407	328	7	kill	kill	VERB
dti-1407	328	8	cancer	cancer	NOUN
dti-1407	328	9	cells	cell	NOUN
dti-1407	328	10	?	?	PUNCT
dti-1407	329	1	j	j	PROPN
dti-1407	329	2	cell	cell	PROPN
dti-1407	329	3	sci	sci	PROPN
dti-1407	329	4	.	.	PUNCT
dti-1407	330	1	2009;122(pt	2009;122(pt	NUM
dti-1407	330	2	15):2579–2585	15):2579–2585	NUM
dti-1407	330	3	.	.	PUNCT
dti-1407	331	1	36	36	NUM
dti-1407	331	2	.	.	PUNCT
dti-1407	332	1	hanahan	hanahan	PROPN
dti-1407	332	2	d	d	PROPN
dti-1407	332	3	,	,	PUNCT
dti-1407	332	4	weinberg	weinberg	PROPN
dti-1407	332	5	ra	ra	PROPN
dti-1407	332	6	.	.	PUNCT
dti-1407	333	1	hallmarks	hallmark	NOUN
dti-1407	333	2	of	of	ADP
dti-1407	333	3	cancer	cancer	NOUN
dti-1407	333	4	:	:	PUNCT
dti-1407	333	5	the	the	DET
dti-1407	333	6	next	next	ADJ
dti-1407	333	7	generation	generation	NOUN
dti-1407	333	8	.	.	PUNCT
dti-1407	334	1	cell	cell	NOUN
dti-1407	334	2	.	.	PUNCT
dti-1407	335	1	2011;144(5):646–674	2011;144(5):646–674	X
dti-1407	335	2	.	.	PUNCT
dti-1407	336	1	37	37	NUM
dti-1407	336	2	.	.	PUNCT
dti-1407	337	1	jordan	jordan	PROPN
dti-1407	337	2	ma	ma	PROPN
dti-1407	337	3	,	,	PUNCT
dti-1407	337	4	wilson	wilson	PROPN
dti-1407	337	5	l.	l.	PROPN
dti-1407	337	6	microtubules	microtubule	NOUN
dti-1407	337	7	as	as	ADP
dti-1407	337	8	a	a	DET
dti-1407	337	9	target	target	NOUN
dti-1407	337	10	for	for	ADP
dti-1407	337	11	anticancer	anticancer	NOUN
dti-1407	337	12	drugs	drug	NOUN
dti-1407	337	13	.	.	PUNCT
dti-1407	338	1	nat	nat	PROPN
dti-1407	338	2	rev	rev	PROPN
dti-1407	338	3	cancer	cancer	NOUN
dti-1407	338	4	.	.	PUNCT
dti-1407	339	1	2004;4(4):253–265	2004;4(4):253–265	X
dti-1407	339	2	.	.	X
dti-1407	339	3	38	38	NUM
dti-1407	339	4	.	.	PUNCT
dti-1407	340	1	pasquier	pasquier	PROPN
dti-1407	340	2	e	e	NOUN
dti-1407	340	3	,	,	PUNCT
dti-1407	340	4	kavallaris	kavallaris	PROPN
dti-1407	340	5	m.	m.	NOUN
dti-1407	340	6	microtubules	microtubule	NOUN
dti-1407	340	7	:	:	PUNCT
dti-1407	340	8	a	a	DET
dti-1407	340	9	dynamic	dynamic	ADJ
dti-1407	340	10	target	target	NOUN
dti-1407	340	11	in	in	ADP
dti-1407	340	12	cancer	cancer	NOUN
dti-1407	340	13	therapy	therapy	NOUN
dti-1407	340	14	.	.	PUNCT
dti-1407	341	1	iubmb	iubmb	NOUN
dti-1407	341	2	life	life	NOUN
dti-1407	341	3	.	.	PUNCT
dti-1407	342	1	2008;60(3):165–170	2008;60(3):165–170	NUM
dti-1407	342	2	.	.	NOUN
dti-1407	342	3	39	39	NUM
dti-1407	342	4	.	.	PUNCT
dti-1407	343	1	dumontet	dumontet	PROPN
dti-1407	343	2	c	c	PROPN
dti-1407	343	3	,	,	PUNCT
dti-1407	343	4	jordan	jordan	PROPN
dti-1407	343	5	ma	ma	PROPN
dti-1407	343	6	.	.	PROPN
dti-1407	343	7	microtubule	microtubule	NOUN
dti-1407	343	8	-	-	PUNCT
dti-1407	343	9	binding	bind	VERB
dti-1407	343	10	agents	agent	NOUN
dti-1407	343	11	:	:	PUNCT
dti-1407	343	12	a	a	DET
dti-1407	343	13	dynamic	dynamic	ADJ
dti-1407	343	14	field	field	NOUN
dti-1407	343	15	of	of	ADP
dti-1407	343	16	cancer	cancer	NOUN
dti-1407	343	17	therapeutics	therapeutic	NOUN
dti-1407	343	18	.	.	PUNCT
dti-1407	344	1	nat	nat	PROPN
dti-1407	344	2	rev	rev	VERB
dti-1407	344	3	drug	drug	NOUN
dti-1407	344	4	discov	discov	PROPN
dti-1407	344	5	.	.	PUNCT
dti-1407	345	1	2010;9(10):790–803	2010;9(10):790–803	X
dti-1407	345	2	.	.	PUNCT
dti-1407	346	1	40	40	NUM
dti-1407	346	2	.	.	PUNCT
dti-1407	347	1	yue	yue	PROPN
dti-1407	347	2	q	q	PROPN
dti-1407	347	3	-	-	PUNCT
dti-1407	347	4	x	x	PROPN
dti-1407	347	5	,	,	PUNCT
dti-1407	347	6	liu	liu	PROPN
dti-1407	347	7	x	x	PROPN
dti-1407	347	8	,	,	PUNCT
dti-1407	347	9	guo	guo	PROPN
dti-1407	347	10	d	d	NOUN
dti-1407	347	11	-	-	PUNCT
dti-1407	347	12	a.	a.	NOUN
dti-1407	347	13	microtubule	microtubule	NOUN
dti-1407	347	14	-	-	PUNCT
dti-1407	347	15	binding	bind	VERB
dti-1407	347	16	natural	natural	ADJ
dti-1407	347	17	products	product	NOUN
dti-1407	347	18	for	for	ADP
dti-1407	347	19	cancer	cancer	NOUN
dti-1407	347	20	therapy	therapy	NOUN
dti-1407	347	21	.	.	PUNCT
dti-1407	348	1	planta	planta	PROPN
dti-1407	348	2	med	med	PROPN
dti-1407	348	3	.	.	PUNCT
dti-1407	349	1	2010;76(11):1037	2010;76(11):1037	NUM
dti-1407	349	2	.	.	NOUN
dti-1407	349	3	41	41	NUM
dti-1407	349	4	.	.	PUNCT
dti-1407	350	1	jordan	jordan	PROPN
dti-1407	350	2	ma	ma	PROPN
dti-1407	350	3	,	,	PUNCT
dti-1407	350	4	thrower	thrower	NOUN
dti-1407	351	1	d	d	NOUN
dti-1407	351	2	,	,	PUNCT
dti-1407	351	3	wilson	wilson	PROPN
dti-1407	351	4	l.	l.	PROPN
dti-1407	351	5	mechanism	mechanism	NOUN
dti-1407	351	6	of	of	ADP
dti-1407	351	7	inhibition	inhibition	NOUN
dti-1407	351	8	of	of	ADP
dti-1407	351	9	cell	cell	NOUN
dti-1407	351	10	proliferation	proliferation	NOUN
dti-1407	351	11	by	by	ADP
dti-1407	351	12	vinca	vinca	NOUN
dti-1407	351	13	alkaloids	alkaloid	NOUN
dti-1407	351	14	.	.	PUNCT
dti-1407	352	1	cancer	cancer	NOUN
dti-1407	352	2	res	re	NOUN
dti-1407	352	3	.	.	PUNCT
dti-1407	353	1	1991;51(8):2212–2222	1991;51(8):2212–2222	NOUN
dti-1407	353	2	.	.	PUNCT
dti-1407	354	1	42	42	NUM
dti-1407	354	2	.	.	PUNCT
dti-1407	355	1	ngan	ngan	PROPN
dti-1407	355	2	vk	vk	PROPN
dti-1407	355	3	,	,	PUNCT
dti-1407	355	4	bellman	bellman	PROPN
dti-1407	355	5	k	k	PROPN
dti-1407	355	6	,	,	PUNCT
dti-1407	355	7	hill	hill	PROPN
dti-1407	355	8	bt	bt	PROPN
dti-1407	355	9	,	,	PUNCT
dti-1407	355	10	wilson	wilson	PROPN
dti-1407	355	11	l	l	PROPN
dti-1407	355	12	,	,	PUNCT
dti-1407	355	13	jordan	jordan	PROPN
dti-1407	355	14	ma	ma	PROPN
dti-1407	355	15	.	.	PROPN
dti-1407	355	16	mechanism	mechanism	NOUN
dti-1407	355	17	of	of	ADP
dti-1407	355	18	mitotic	mitotic	ADJ
dti-1407	355	19	block	block	NOUN
dti-1407	355	20	and	and	CCONJ
dti-1407	355	21	inhibition	inhibition	NOUN
dti-1407	355	22	of	of	ADP
dti-1407	355	23	cell	cell	NOUN
dti-1407	355	24	proliferation	proliferation	NOUN
dti-1407	355	25	by	by	ADP
dti-1407	355	26	the	the	DET
dti-1407	355	27	semisynthetic	semisynthetic	ADJ
dti-1407	355	28	vinca	vinca	NOUN
dti-1407	355	29	alkaloids	alkaloid	NOUN
dti-1407	355	30	vinorelbine	vinorelbine	NOUN
dti-1407	355	31	and	and	CCONJ
dti-1407	355	32	its	its	PRON
dti-1407	355	33	newer	new	ADJ
dti-1407	355	34	derivative	derivative	ADJ
dti-1407	355	35	vinflunine	vinflunine	NOUN
dti-1407	355	36	.	.	PUNCT
dti-1407	356	1	mol	mol	ADP
dti-1407	356	2	pharmacol	pharmacol	PROPN
dti-1407	356	3	.	.	PUNCT
dti-1407	357	1	2001;60(1):225–232	2001;60(1):225–232	X
dti-1407	357	2	.	.	PROPN
dti-1407	358	1	43	43	NUM
dti-1407	358	2	.	.	PUNCT
dti-1407	359	1	jordan	jordan	PROPN
dti-1407	359	2	ma	ma	PROPN
dti-1407	359	3	,	,	PUNCT
dti-1407	359	4	thrower	thrower	NOUN
dti-1407	359	5	d	d	NOUN
dti-1407	359	6	,	,	PUNCT
dti-1407	359	7	wilson	wilson	PROPN
dti-1407	359	8	l.	l.	PROPN
dti-1407	359	9	effects	effect	NOUN
dti-1407	359	10	of	of	ADP
dti-1407	359	11	vinblastine	vinblastine	NOUN
dti-1407	359	12	,	,	PUNCT
dti-1407	359	13	podophyllotoxin	podophyllotoxin	NOUN
dti-1407	359	14	and	and	CCONJ
dti-1407	359	15	nocodazole	nocodazole	NOUN
dti-1407	359	16	on	on	ADP
dti-1407	359	17	mitotic	mitotic	ADJ
dti-1407	359	18	spindles	spindle	NOUN
dti-1407	359	19	.	.	PUNCT
dti-1407	360	1	implications	implication	NOUN
dti-1407	360	2	for	for	ADP
dti-1407	360	3	the	the	DET
dti-1407	360	4	role	role	NOUN
dti-1407	360	5	of	of	ADP
dti-1407	360	6	microtubule	microtubule	NOUN
dti-1407	360	7	dynamics	dynamic	NOUN
dti-1407	360	8	in	in	ADP
dti-1407	360	9	mitosis	mitosis	NOUN
dti-1407	360	10	.	.	PUNCT
dti-1407	361	1	j	j	PROPN
dti-1407	361	2	cell	cell	PROPN
dti-1407	361	3	sci	sci	PROPN
dti-1407	361	4	.	.	PUNCT
dti-1407	362	1	1992;102(pt	1992;102(pt	PROPN
dti-1407	362	2	3):401–416	3):401–416	NUM
dti-1407	362	3	.	.	PUNCT
dti-1407	363	1	44	44	NUM
dti-1407	363	2	.	.	PUNCT
dti-1407	364	1	dhamodharan	dhamodharan	VERB
dti-1407	364	2	r	r	PROPN
dti-1407	364	3	,	,	PUNCT
dti-1407	364	4	jordan	jordan	PROPN
dti-1407	364	5	ma	ma	PROPN
dti-1407	364	6	,	,	PUNCT
dti-1407	365	1	thrower	thrower	NOUN
dti-1407	365	2	d	d	NOUN
dti-1407	365	3	,	,	PUNCT
dti-1407	365	4	wilson	wilson	PROPN
dti-1407	365	5	l	l	PROPN
dti-1407	365	6	,	,	PUNCT
dti-1407	365	7	wadsworth	wadsworth	PROPN
dti-1407	365	8	p.	p.	PROPN
dti-1407	365	9	vinblastine	vinblastine	NOUN
dti-1407	365	10	suppresses	suppress	VERB
dti-1407	365	11	dynamics	dynamic	NOUN
dti-1407	365	12	of	of	ADP
dti-1407	365	13	individual	individual	ADJ
dti-1407	365	14	microtubules	microtubule	NOUN
dti-1407	365	15	in	in	ADP
dti-1407	365	16	living	live	VERB
dti-1407	365	17	interphase	interphase	NOUN
dti-1407	365	18	cells	cell	NOUN
dti-1407	365	19	.	.	PUNCT
dti-1407	366	1	mol	mol	ADP
dti-1407	366	2	biol	biol	ADJ
dti-1407	366	3	cell	cell	NOUN
dti-1407	366	4	.	.	PUNCT
dti-1407	367	1	1995;6(9):1215–1229	1995;6(9):1215–1229	X
dti-1407	367	2	.	.	PUNCT
dti-1407	368	1	45	45	NUM
dti-1407	368	2	.	.	PUNCT
dti-1407	369	1	gan	gan	PROPN
dti-1407	369	2	pp	pp	ADP
dti-1407	369	3	,	,	PUNCT
dti-1407	369	4	mccarroll	mccarroll	VERB
dti-1407	369	5	ja	ja	PROPN
dti-1407	369	6	,	,	PUNCT
dti-1407	369	7	po’uha	po’uha	PROPN
dti-1407	369	8	st	st	PROPN
dti-1407	369	9	,	,	PUNCT
dti-1407	369	10	kamath	kamath	PROPN
dti-1407	369	11	k	k	PROPN
dti-1407	369	12	,	,	PUNCT
dti-1407	369	13	jordan	jordan	PROPN
dti-1407	369	14	ma	ma	PROPN
dti-1407	369	15	,	,	PUNCT
dti-1407	369	16	kavallaris	kavallaris	PROPN
dti-1407	369	17	m.	m.	NOUN
dti-1407	369	18	microtubule	microtubule	NOUN
dti-1407	369	19	dynamics	dynamic	NOUN
dti-1407	369	20	,	,	PUNCT
dti-1407	369	21	mitotic	mitotic	ADJ
dti-1407	369	22	arrest	arrest	NOUN
dti-1407	369	23	,	,	PUNCT
dti-1407	369	24	and	and	CCONJ
dti-1407	369	25	apoptosis	apoptosis	NOUN
dti-1407	369	26	:	:	PUNCT
dti-1407	369	27	drug	drug	NOUN
dti-1407	369	28	-	-	PUNCT
dti-1407	369	29	induced	induce	VERB
dti-1407	369	30	differential	differential	ADJ
dti-1407	369	31	effects	effect	NOUN
dti-1407	369	32	of	of	ADP
dti-1407	369	33	betaiii	betaiii	NOUN
dti-1407	369	34	-	-	PUNCT
dti-1407	369	35	tubulin	tubulin	NOUN
dti-1407	369	36	.	.	PUNCT
dti-1407	370	1	mol	mol	ADP
dti-1407	370	2	cancer	cancer	NOUN
dti-1407	370	3	ther	ther	ADV
dti-1407	370	4	.	.	PUNCT
dti-1407	371	1	2010;9(5):1339–1348	2010;9(5):1339–1348	X
dti-1407	371	2	.	.	PUNCT
dti-1407	372	1	46	46	NUM
dti-1407	372	2	.	.	PUNCT
dti-1407	373	1	fojo	fojo	PROPN
dti-1407	373	2	t	t	PROPN
dti-1407	373	3	,	,	PUNCT
dti-1407	373	4	menefee	menefee	NOUN
dti-1407	373	5	m.	m.	NOUN
dti-1407	373	6	mechanisms	mechanism	NOUN
dti-1407	373	7	of	of	ADP
dti-1407	373	8	multidrug	multidrug	NOUN
dti-1407	373	9	resistance	resistance	NOUN
dti-1407	373	10	:	:	PUNCT
dti-1407	373	11	the	the	DET
dti-1407	373	12	potential	potential	ADJ
dti-1407	373	13	role	role	NOUN
dti-1407	373	14	of	of	ADP
dti-1407	373	15	microtubule	microtubule	NOUN
dti-1407	373	16	-	-	PUNCT
dti-1407	373	17	stabilizing	stabilize	VERB
dti-1407	373	18	agents	agent	NOUN
dti-1407	373	19	.	.	PUNCT
dti-1407	374	1	ann	ann	PROPN
dti-1407	374	2	oncol	oncol	PROPN
dti-1407	374	3	.	.	PUNCT
dti-1407	375	1	2007;18(suppl	2007;18(suppl	PROPN
dti-1407	375	2	5):v3	5):v3	NUM
dti-1407	375	3	–	–	PUNCT
dti-1407	375	4	v8	v8	NOUN
dti-1407	375	5	.	.	PUNCT
dti-1407	376	1	47	47	NUM
dti-1407	376	2	.	.	PUNCT
dti-1407	377	1	schiff	schiff	PROPN
dti-1407	377	2	pb	pb	PROPN
dti-1407	377	3	,	,	PUNCT
dti-1407	377	4	horwitz	horwitz	PROPN
dti-1407	377	5	sb	sb	PROPN
dti-1407	377	6	.	.	PROPN
dti-1407	377	7	taxol	taxol	PROPN
dti-1407	377	8	stabilizes	stabilize	VERB
dti-1407	377	9	microtubules	microtubule	NOUN
dti-1407	377	10	in	in	ADP
dti-1407	377	11	mouse	mouse	NOUN
dti-1407	377	12	fibroblast	fibroblast	ADJ
dti-1407	377	13	cells	cell	NOUN
dti-1407	377	14	.	.	PUNCT
dti-1407	378	1	proc	proc	PROPN
dti-1407	378	2	natl	natl	PROPN
dti-1407	378	3	acad	acad	PROPN
dti-1407	378	4	sci	sci	PROPN
dti-1407	378	5	u	u	PROPN
dti-1407	378	6	s	s	NOUN
dti-1407	378	7	a.	a.	NOUN
dti-1407	378	8	1980;77(3):1561–1565	1980;77(3):1561–1565	NUM
dti-1407	378	9	.	.	PUNCT
dti-1407	379	1	48	48	NUM
dti-1407	379	2	.	.	PUNCT
dti-1407	380	1	manfredi	manfredi	PROPN
dti-1407	380	2	jj	jj	PROPN
dti-1407	380	3	,	,	PUNCT
dti-1407	380	4	parness	parness	PROPN
dti-1407	380	5	j	j	PROPN
dti-1407	380	6	,	,	PUNCT
dti-1407	380	7	horwitz	horwitz	PROPN
dti-1407	380	8	sb	sb	PROPN
dti-1407	380	9	.	.	PROPN
dti-1407	380	10	taxol	taxol	PROPN
dti-1407	380	11	binds	bind	VERB
dti-1407	380	12	to	to	ADP
dti-1407	380	13	cellular	cellular	ADJ
dti-1407	380	14	microtubules	microtubule	NOUN
dti-1407	380	15	.	.	PUNCT
dti-1407	381	1	j	j	PROPN
dti-1407	381	2	cell	cell	NOUN
dti-1407	381	3	biol	biol	PROPN
dti-1407	381	4	.	.	PUNCT
dti-1407	382	1	1982;94(3):688–696	1982;94(3):688–696	NUM
dti-1407	382	2	.	.	X
dti-1407	383	1	49	49	NUM
dti-1407	383	2	.	.	PUNCT
dti-1407	384	1	panda	panda	NOUN
dti-1407	384	2	d	d	PROPN
dti-1407	384	3	,	,	PUNCT
dti-1407	384	4	jordan	jordan	PROPN
dti-1407	384	5	ma	ma	PROPN
dti-1407	384	6	,	,	PUNCT
dti-1407	384	7	chu	chu	PROPN
dti-1407	384	8	kc	kc	PROPN
dti-1407	384	9	,	,	PUNCT
dti-1407	384	10	wilson	wilson	PROPN
dti-1407	384	11	l.	l.	PROPN
dti-1407	384	12	differential	differential	PROPN
dti-1407	384	13	effects	effect	NOUN
dti-1407	384	14	of	of	ADP
dti-1407	384	15	vinblastine	vinblastine	NOUN
dti-1407	384	16	on	on	ADP
dti-1407	384	17	polymerization	polymerization	NOUN
dti-1407	384	18	and	and	CCONJ
dti-1407	384	19	dynamics	dynamic	NOUN
dti-1407	384	20	at	at	ADP
dti-1407	384	21	opposite	opposite	ADJ
dti-1407	384	22	microtubule	microtubule	NOUN
dti-1407	384	23	ends	end	VERB
dti-1407	384	24	.	.	PUNCT
dti-1407	385	1	j	j	PROPN
dti-1407	385	2	biol	biol	PROPN
dti-1407	385	3	chem	chem	NOUN
dti-1407	385	4	.	.	PUNCT
dti-1407	386	1	1996	1996	NUM
dti-1407	386	2	;	;	PUNCT
dti-1407	387	1	271(47):29807–29812	271(47):29807–29812	NUM
dti-1407	387	2	.	.	PUNCT
dti-1407	388	1	50	50	NUM
dti-1407	388	2	.	.	PUNCT
dti-1407	389	1	prakash	prakash	PROPN
dti-1407	389	2	v	v	PROPN
dti-1407	389	3	,	,	PUNCT
dti-1407	389	4	timasheff	timasheff	PROPN
dti-1407	389	5	sn	sn	PROPN
dti-1407	389	6	.	.	PUNCT
dti-1407	390	1	the	the	DET
dti-1407	390	2	interaction	interaction	NOUN
dti-1407	390	3	of	of	ADP
dti-1407	390	4	vincristine	vincristine	NOUN
dti-1407	390	5	with	with	ADP
dti-1407	390	6	calf	calf	NOUN
dti-1407	390	7	brain	brain	NOUN
dti-1407	390	8	tubulin	tubulin	NOUN
dti-1407	390	9	.	.	PUNCT
dti-1407	391	1	j	j	PROPN
dti-1407	391	2	biol	biol	PROPN
dti-1407	391	3	chem	chem	NOUN
dti-1407	391	4	.	.	PUNCT
dti-1407	392	1	1983;258(3):1689–1697	1983;258(3):1689–1697	NUM
dti-1407	392	2	.	.	PUNCT
dti-1407	393	1	51	51	NUM
dti-1407	393	2	.	.	PUNCT
dti-1407	394	1	vandecandelaere	vandecandelaere	ADV
dti-1407	394	2	a	a	PRON
dti-1407	394	3	,	,	PUNCT
dti-1407	394	4	martin	martin	PROPN
dti-1407	394	5	sr	sr	PROPN
dti-1407	394	6	,	,	PUNCT
dti-1407	394	7	engelborghs	engelborghs	VERB
dti-1407	394	8	y.	y.	NOUN
dti-1407	394	9	response	response	NOUN
dti-1407	394	10	of	of	ADP
dti-1407	394	11	microtubules	microtubule	NOUN
dti-1407	394	12	to	to	ADP
dti-1407	394	13	the	the	DET
dti-1407	394	14	addition	addition	NOUN
dti-1407	394	15	of	of	ADP
dti-1407	394	16	colchicine	colchicine	NOUN
dti-1407	394	17	and	and	CCONJ
dti-1407	394	18	tubulin	tubulin	NOUN
dti-1407	394	19	-	-	PUNCT
dti-1407	394	20	colchicine	colchicine	NOUN
dti-1407	394	21	:	:	PUNCT
dti-1407	394	22	evaluation	evaluation	NOUN
dti-1407	394	23	of	of	ADP
dti-1407	394	24	models	model	NOUN
dti-1407	394	25	for	for	ADP
dti-1407	394	26	the	the	DET
dti-1407	394	27	interaction	interaction	NOUN
dti-1407	394	28	of	of	ADP
dti-1407	394	29	drugs	drug	NOUN
dti-1407	394	30	with	with	ADP
dti-1407	394	31	microtubules	microtubule	NOUN
dti-1407	394	32	.	.	PUNCT
dti-1407	395	1	biochem	biochem	PROPN
dti-1407	395	2	j.	j.	PROPN
dti-1407	395	3	1997;323(pt	1997;323(pt	PROPN
dti-1407	395	4	1):189–196	1):189–196	NUM
dti-1407	395	5	.	.	PUNCT
dti-1407	396	1	52	52	NUM
dti-1407	396	2	.	.	PUNCT
dti-1407	397	1	taylor	taylor	PROPN
dti-1407	397	2	ew	ew	PROPN
dti-1407	397	3	.	.	PUNCT
dti-1407	398	1	the	the	DET
dti-1407	398	2	mechanism	mechanism	NOUN
dti-1407	398	3	of	of	ADP
dti-1407	398	4	colchicine	colchicine	NOUN
dti-1407	398	5	inhibition	inhibition	NOUN
dti-1407	398	6	of	of	ADP
dti-1407	398	7	mitosis	mitosis	NOUN
dti-1407	398	8	.	.	PUNCT
dti-1407	399	1	i.	i.	PROPN
dti-1407	399	2	kinetics	kinetics	PROPN
dti-1407	399	3	of	of	ADP
dti-1407	399	4	inhibition	inhibition	NOUN
dti-1407	399	5	and	and	CCONJ
dti-1407	399	6	the	the	DET
dti-1407	399	7	binding	binding	NOUN
dti-1407	399	8	of	of	ADP
dti-1407	399	9	h3	h3	NOUN
dti-1407	399	10	-	-	PUNCT
dti-1407	399	11	colchicine	colchicine	NOUN
dti-1407	399	12	.	.	PUNCT
dti-1407	400	1	j	j	PROPN
dti-1407	400	2	cell	cell	PROPN
dti-1407	400	3	biol	biol	PROPN
dti-1407	400	4	.	.	PUNCT
dti-1407	401	1	1965;25(suppl):145–160	1965;25(suppl):145–160	NOUN
dti-1407	401	2	.	.	PROPN
dti-1407	402	1	53	53	NUM
dti-1407	402	2	.	.	PUNCT
dti-1407	402	3	tangutoori	tangutoori	PROPN
dti-1407	402	4	s	s	PROPN
dti-1407	402	5	,	,	PUNCT
dti-1407	402	6	ohta	ohta	VERB
dti-1407	402	7	a	a	DET
dti-1407	402	8	,	,	PUNCT
dti-1407	402	9	gatley	gatley	NOUN
dti-1407	402	10	s	s	PROPN
dti-1407	402	11	,	,	PUNCT
dti-1407	402	12	campbell	campbell	PROPN
dti-1407	402	13	r.	r.	PROPN
dti-1407	402	14	repurposing	repurpose	VERB
dti-1407	402	15	an	an	DET
dti-1407	402	16	erstwhile	erstwhile	ADJ
dti-1407	402	17	cancer	cancer	NOUN
dti-1407	402	18	drug	drug	NOUN
dti-1407	402	19	:	:	PUNCT
dti-1407	402	20	a	a	DET
dti-1407	402	21	quantitative	quantitative	ADJ
dti-1407	402	22	and	and	CCONJ
dti-1407	402	23	therapeutic	therapeutic	ADJ
dti-1407	402	24	evaluation	evaluation	NOUN
dti-1407	402	25	of	of	ADP
dti-1407	402	26	alternative	alternative	ADJ
dti-1407	402	27	nanosystems	nanosystem	NOUN
dti-1407	402	28	for	for	ADP
dti-1407	402	29	the	the	DET
dti-1407	402	30	delivery	delivery	NOUN
dti-1407	402	31	of	of	ADP
dti-1407	402	32	colchicine	colchicine	PROPN
dti-1407	402	33	to	to	ADP
dti-1407	402	34	solid	solid	ADJ
dti-1407	402	35	tumors	tumor	NOUN
dti-1407	402	36	.	.	PUNCT
dti-1407	403	1	j	j	PROPN
dti-1407	403	2	cancer	cancer	NOUN
dti-1407	403	3	sci	sci	PROPN
dti-1407	403	4	ther	ther	ADV
dti-1407	403	5	.	.	PUNCT
dti-1407	404	1	2014;6:236–246	2014;6:236–246	NUM
dti-1407	404	2	.	.	PUNCT
dti-1407	405	1	54	54	NUM
dti-1407	405	2	.	.	PUNCT
dti-1407	405	3	schilstra	schilstra	PROPN
dti-1407	405	4	mj	mj	PROPN
dti-1407	405	5	,	,	PUNCT
dti-1407	405	6	martin	martin	PROPN
dti-1407	405	7	sr	sr	PROPN
dti-1407	405	8	,	,	PUNCT
dti-1407	405	9	bayley	bayley	PROPN
dti-1407	405	10	pm	pm	PROPN
dti-1407	405	11	.	.	PUNCT
dti-1407	406	1	the	the	DET
dti-1407	406	2	effect	effect	NOUN
dti-1407	406	3	of	of	ADP
dti-1407	406	4	podophyllotoxin	podophyllotoxin	NOUN
dti-1407	406	5	on	on	ADP
dti-1407	406	6	microtubule	microtubule	NOUN
dti-1407	406	7	dynamics	dynamic	NOUN
dti-1407	406	8	.	.	PUNCT
dti-1407	407	1	j	j	PROPN
dti-1407	407	2	biol	biol	PROPN
dti-1407	407	3	chem	chem	NOUN
dti-1407	407	4	.	.	PUNCT
dti-1407	408	1	1989;264(15):8827–8834	1989;264(15):8827–8834	NUM
dti-1407	408	2	.	.	PUNCT
dti-1407	409	1	55	55	NUM
dti-1407	409	2	.	.	PUNCT
dti-1407	410	1	bruschi	bruschi	PROPN
dti-1407	410	2	m	m	PROPN
dti-1407	410	3	,	,	PUNCT
dti-1407	410	4	rindone	rindone	PROPN
dti-1407	410	5	b	b	PROPN
dti-1407	410	6	,	,	PUNCT
dti-1407	410	7	tollpa	tollpa	PROPN
dti-1407	410	8	el	el	PROPN
dti-1407	410	9	,	,	PUNCT
dti-1407	410	10	et	et	PROPN
dti-1407	410	11	al	al	PROPN
dti-1407	410	12	.	.	PROPN
dti-1407	410	13	podophyllotoxin	podophyllotoxin	PROPN
dti-1407	410	14	and	and	CCONJ
dti-1407	410	15	antitumor	antitumor	PROPN
dti-1407	410	16	synthetic	synthetic	ADJ
dti-1407	410	17	aryltetralines	aryltetraline	NOUN
dti-1407	410	18	.	.	PUNCT
dti-1407	411	1	toward	toward	ADP
dti-1407	411	2	a	a	DET
dti-1407	411	3	biomimetic	biomimetic	ADJ
dti-1407	411	4	preparation	preparation	NOUN
dti-1407	411	5	.	.	PUNCT
dti-1407	412	1	croatia	croatia	PROPN
dti-1407	412	2	:	:	PUNCT
dti-1407	412	3	intech	intech	PROPN
dti-1407	412	4	open	open	PROPN
dti-1407	412	5	access	access	NOUN
dti-1407	412	6	publisher	publisher	NOUN
dti-1407	412	7	;	;	PUNCT
dti-1407	412	8	2010	2010	NUM
dti-1407	412	9	.	.	PUNCT
dti-1407	413	1	56	56	NUM
dti-1407	413	2	.	.	PUNCT
dti-1407	414	1	tozer	tozer	PROPN
dti-1407	414	2	gm	gm	PROPN
dti-1407	414	3	,	,	PUNCT
dti-1407	414	4	kanthou	kanthou	PROPN
dti-1407	414	5	c	c	PROPN
dti-1407	414	6	,	,	PUNCT
dti-1407	414	7	parkins	parkins	PROPN
dti-1407	414	8	cs	cs	PROPN
dti-1407	414	9	,	,	PUNCT
dti-1407	414	10	hill	hill	PROPN
dti-1407	414	11	sa	sa	PROPN
dti-1407	414	12	.	.	PUNCT
dti-1407	415	1	the	the	DET
dti-1407	415	2	biology	biology	NOUN
dti-1407	415	3	of	of	ADP
dti-1407	415	4	the	the	DET
dti-1407	415	5	combretastatins	combretastatin	NOUN
dti-1407	415	6	as	as	ADP
dti-1407	415	7	tumour	tumour	NOUN
dti-1407	415	8	vascular	vascular	ADJ
dti-1407	415	9	targeting	targeting	NOUN
dti-1407	415	10	agents	agent	NOUN
dti-1407	415	11	.	.	PUNCT
dti-1407	416	1	int	int	NOUN
dti-1407	416	2	j	j	PROPN
dti-1407	416	3	exp	exp	NOUN
dti-1407	416	4	pathol	pathol	NOUN
dti-1407	416	5	.	.	PUNCT
dti-1407	417	1	2002;83(1):21–38	2002;83(1):21–38	NUM
dti-1407	417	2	.	.	PROPN
dti-1407	417	3	57	57	NUM
dti-1407	417	4	.	.	PUNCT
dti-1407	418	1	landen	landen	PROPN
dti-1407	418	2	jw	jw	PROPN
dti-1407	418	3	,	,	PUNCT
dti-1407	418	4	lang	lang	PROPN
dti-1407	418	5	r	r	PROPN
dti-1407	418	6	,	,	PUNCT
dti-1407	418	7	mcmahon	mcmahon	PROPN
dti-1407	418	8	sj	sj	PROPN
dti-1407	418	9	,	,	PUNCT
dti-1407	418	10	et	et	PROPN
dti-1407	418	11	al	al	PROPN
dti-1407	418	12	.	.	PROPN
dti-1407	418	13	noscapine	noscapine	PROPN
dti-1407	418	14	alters	alter	VERB
dti-1407	418	15	microtubule	microtubule	NOUN
dti-1407	418	16	dynamics	dynamic	NOUN
dti-1407	418	17	in	in	ADP
dti-1407	418	18	living	living	NOUN
dti-1407	418	19	cells	cell	NOUN
dti-1407	418	20	and	and	CCONJ
dti-1407	418	21	inhibits	inhibit	VERB
dti-1407	418	22	the	the	DET
dti-1407	418	23	progression	progression	NOUN
dti-1407	418	24	of	of	ADP
dti-1407	418	25	melanoma	melanoma	NOUN
dti-1407	418	26	.	.	PUNCT
dti-1407	419	1	cancer	cancer	NOUN
dti-1407	419	2	res	re	NOUN
dti-1407	419	3	.	.	PUNCT
dti-1407	420	1	2002;62(14	2002;62(14	NUM
dti-1407	420	2	):	):	PUNCT
dti-1407	420	3	4109–4114	4109–4114	NUM
dti-1407	420	4	.	.	PUNCT
dti-1407	421	1	58	58	NUM
dti-1407	421	2	.	.	PUNCT
dti-1407	422	1	jordan	jordan	PROPN
dti-1407	422	2	ma	ma	PROPN
dti-1407	422	3	,	,	PUNCT
dti-1407	422	4	himes	himes	PROPN
dti-1407	422	5	rh	rh	PROPN
dti-1407	422	6	,	,	PUNCT
dti-1407	422	7	wilson	wilson	PROPN
dti-1407	422	8	l.	l.	PROPN
dti-1407	422	9	comparison	comparison	NOUN
dti-1407	422	10	of	of	ADP
dti-1407	422	11	the	the	DET
dti-1407	422	12	effects	effect	NOUN
dti-1407	422	13	of	of	ADP
dti-1407	422	14	vinblastine	vinblastine	NOUN
dti-1407	422	15	,	,	PUNCT
dti-1407	422	16	vincristine	vincristine	NOUN
dti-1407	422	17	,	,	PUNCT
dti-1407	422	18	vindesine	vindesine	NOUN
dti-1407	422	19	,	,	PUNCT
dti-1407	422	20	and	and	CCONJ
dti-1407	422	21	vinepidine	vinepidine	VERB
dti-1407	422	22	on	on	ADP
dti-1407	422	23	microtubule	microtubule	NOUN
dti-1407	422	24	dynamics	dynamic	NOUN
dti-1407	422	25	and	and	CCONJ
dti-1407	422	26	cell	cell	NOUN
dti-1407	422	27	proliferation	proliferation	NOUN
dti-1407	422	28	in	in	ADP
dti-1407	422	29	vitro	vitro	X
dti-1407	422	30	.	.	PUNCT
dti-1407	423	1	cancer	cancer	NOUN
dti-1407	423	2	res	re	NOUN
dti-1407	423	3	.	.	PUNCT
dti-1407	424	1	1985;45(6):2741–2747	1985;45(6):2741–2747	PROPN
dti-1407	424	2	.	.	PUNCT
dti-1407	425	1	59	59	NUM
dti-1407	425	2	.	.	PUNCT
dti-1407	426	1	klotz	klotz	PROPN
dti-1407	426	2	dm	dm	PROPN
dti-1407	426	3	,	,	PUNCT
dti-1407	426	4	nelson	nelson	PROPN
dti-1407	426	5	sa	sa	PROPN
dti-1407	426	6	,	,	PUNCT
dti-1407	426	7	kroboth	kroboth	PROPN
dti-1407	426	8	k	k	PROPN
dti-1407	426	9	,	,	PUNCT
dti-1407	426	10	et	et	PROPN
dti-1407	426	11	al	al	PROPN
dti-1407	426	12	.	.	PUNCT
dti-1407	427	1	the	the	DET
dti-1407	427	2	microtubule	microtubule	NOUN
dti-1407	427	3	poison	poison	NOUN
dti-1407	427	4	vinorelbine	vinorelbine	NOUN
dti-1407	427	5	kills	kill	VERB
dti-1407	427	6	cells	cell	NOUN
dti-1407	427	7	independently	independently	ADV
dti-1407	427	8	of	of	ADP
dti-1407	427	9	mitotic	mitotic	ADJ
dti-1407	427	10	arrest	arrest	NOUN
dti-1407	427	11	and	and	CCONJ
dti-1407	427	12	targets	target	VERB
dti-1407	427	13	cells	cell	NOUN
dti-1407	427	14	lacking	lack	VERB
dti-1407	427	15	the	the	DET
dti-1407	427	16	apc	apc	PROPN
dti-1407	427	17	tumour	tumour	NOUN
dti-1407	427	18	suppressor	suppressor	NOUN
dti-1407	427	19	more	more	ADV
dti-1407	427	20	effectively	effectively	ADV
dti-1407	427	21	.	.	PUNCT
dti-1407	428	1	j	j	PROPN
dti-1407	428	2	cell	cell	PROPN
dti-1407	428	3	sci	sci	PROPN
dti-1407	428	4	.	.	PUNCT
dti-1407	429	1	2012;125(pt	2012;125(pt	PROPN
dti-1407	429	2	4):887–895	4):887–895	NUM
dti-1407	429	3	.	.	PUNCT
dti-1407	429	4	60	60	NUM
dti-1407	429	5	.	.	PUNCT
dti-1407	430	1	zhang	zhang	PROPN
dti-1407	430	2	j	j	PROPN
dti-1407	430	3	,	,	PUNCT
dti-1407	430	4	qi	qi	PROPN
dti-1407	430	5	hw	hw	PROPN
dti-1407	430	6	,	,	PUNCT
dti-1407	430	7	zheng	zheng	PROPN
dti-1407	430	8	h	h	PROPN
dti-1407	430	9	,	,	PUNCT
dti-1407	430	10	et	et	PROPN
dti-1407	430	11	al	al	PROPN
dti-1407	430	12	.	.	PROPN
dti-1407	430	13	etoposide	etoposide	NOUN
dti-1407	430	14	-	-	PUNCT
dti-1407	430	15	cisplatin	cisplatin	NOUN
dti-1407	430	16	alternating	alternating	NOUN
dti-1407	430	17	with	with	ADP
dti-1407	430	18	vinorelbinecisplatin	vinorelbinecisplatin	PROPN
dti-1407	430	19	versus	versus	ADP
dti-1407	430	20	etoposide	etoposide	NOUN
dti-1407	430	21	-	-	PUNCT
dti-1407	430	22	cisplatin	cisplatin	NOUN
dti-1407	430	23	alone	alone	ADV
dti-1407	430	24	in	in	ADP
dti-1407	430	25	patients	patient	NOUN
dti-1407	430	26	with	with	ADP
dti-1407	430	27	extensive	extensive	ADJ
dti-1407	430	28	disease	disease	NOUN
dti-1407	430	29	combined	combine	VERB
dti-1407	430	30	with	with	ADP
dti-1407	430	31	small	small	ADJ
dti-1407	430	32	cell	cell	NOUN
dti-1407	430	33	lung	lung	NOUN
dti-1407	430	34	cancer	cancer	NOUN
dti-1407	430	35	.	.	PUNCT
dti-1407	431	1	asian	asian	PROPN
dti-1407	431	2	pac	pac	PROPN
dti-1407	431	3	j	j	PROPN
dti-1407	431	4	cancer	cancer	NOUN
dti-1407	431	5	prev	prev	X
dti-1407	431	6	.	.	PUNCT
dti-1407	432	1	2014;15(10):4159	2014;15(10):4159	NUM
dti-1407	432	2	.	.	NOUN
dti-1407	432	3	61	61	NUM
dti-1407	432	4	.	.	PUNCT
dti-1407	433	1	garcia	garcia	PROPN
dti-1407	433	2	p	p	X
dti-1407	433	3	,	,	PUNCT
dti-1407	433	4	braguer	braguer	PROPN
dti-1407	433	5	d	d	PROPN
dti-1407	433	6	,	,	PUNCT
dti-1407	433	7	carles	carle	VERB
dti-1407	433	8	g	g	PROPN
dti-1407	433	9	,	,	PUNCT
dti-1407	433	10	et	et	PROPN
dti-1407	433	11	al	al	PROPN
dti-1407	433	12	.	.	PROPN
dti-1407	434	1	comparative	comparative	ADJ
dti-1407	434	2	effects	effect	NOUN
dti-1407	434	3	of	of	ADP
dti-1407	434	4	taxol	taxol	PROPN
dti-1407	434	5	and	and	CCONJ
dti-1407	434	6	taxotere	taxotere	VERB
dti-1407	434	7	on	on	ADP
dti-1407	434	8	two	two	NUM
dti-1407	434	9	different	different	ADJ
dti-1407	434	10	human	human	ADJ
dti-1407	434	11	carcinoma	carcinoma	NOUN
dti-1407	434	12	cell	cell	NOUN
dti-1407	434	13	lines	line	NOUN
dti-1407	434	14	.	.	PUNCT
dti-1407	435	1	cancer	cancer	NOUN
dti-1407	435	2	chemother	chemother	PROPN
dti-1407	435	3	pharmacol	pharmacol	PROPN
dti-1407	435	4	.	.	PROPN
dti-1407	435	5	1994	1994	NUM
dti-1407	435	6	;	;	PUNCT
dti-1407	436	1	34(4):335–343	34(4):335–343	NOUN
dti-1407	436	2	.	.	PUNCT
dti-1407	437	1	62	62	NUM
dti-1407	437	2	.	.	PUNCT
dti-1407	438	1	kunos	kunos	PROPN
dti-1407	438	2	ca	ca	PROPN
dti-1407	438	3	,	,	PUNCT
dti-1407	438	4	stefan	stefan	PROPN
dti-1407	438	5	t	t	PROPN
dti-1407	438	6	,	,	PUNCT
dti-1407	438	7	jacobberger	jacobberger	PROPN
dti-1407	438	8	jw	jw	PROPN
dti-1407	438	9	.	.	PUNCT
dti-1407	438	10	cabazitaxel	cabazitaxel	PROPN
dti-1407	438	11	-	-	PUNCT
dti-1407	438	12	induced	induce	VERB
dti-1407	438	13	stabilization	stabilization	NOUN
dti-1407	438	14	of	of	ADP
dti-1407	438	15	microtubules	microtubule	NOUN
dti-1407	438	16	enhances	enhance	VERB
dti-1407	438	17	radiosensitivity	radiosensitivity	NOUN
dti-1407	438	18	in	in	ADP
dti-1407	438	19	ovarian	ovarian	ADJ
dti-1407	438	20	cancer	cancer	NOUN
dti-1407	438	21	cells	cell	NOUN
dti-1407	438	22	.	.	PUNCT
dti-1407	439	1	front	front	ADJ
dti-1407	439	2	oncol	oncol	ADJ
dti-1407	439	3	.	.	PUNCT
dti-1407	440	1	2013;3:226	2013;3:226	X
dti-1407	440	2	.	.	PUNCT
dti-1407	441	1	63	63	NUM
dti-1407	441	2	.	.	PUNCT
dti-1407	442	1	yared	yared	PROPN
dti-1407	442	2	ja	ja	PROPN
dti-1407	442	3	,	,	PUNCT
dti-1407	442	4	tkaczuk	tkaczuk	PROPN
dti-1407	442	5	kh	kh	PROPN
dti-1407	442	6	.	.	PUNCT
dti-1407	442	7	update	update	NOUN
dti-1407	442	8	on	on	ADP
dti-1407	442	9	taxane	taxane	NOUN
dti-1407	442	10	development	development	NOUN
dti-1407	442	11	:	:	PUNCT
dti-1407	442	12	new	new	ADJ
dti-1407	442	13	analogs	analog	NOUN
dti-1407	442	14	and	and	CCONJ
dti-1407	442	15	new	new	ADJ
dti-1407	442	16	formulations	formulation	NOUN
dti-1407	442	17	.	.	PUNCT
dti-1407	443	1	drug	drug	NOUN
dti-1407	443	2	des	des	PROPN
dti-1407	443	3	devel	devel	NOUN
dti-1407	443	4	ther	ther	ADV
dti-1407	443	5	.	.	PUNCT
dti-1407	444	1	2012;6:371–384	2012;6:371–384	NUM
dti-1407	444	2	.	.	NOUN
dti-1407	444	3	64	64	NUM
dti-1407	444	4	.	.	PUNCT
dti-1407	445	1	nihei	nihei	PROPN
dti-1407	445	2	y	y	PROPN
dti-1407	445	3	,	,	PUNCT
dti-1407	445	4	suzuki	suzuki	PROPN
dti-1407	445	5	m	m	PROPN
dti-1407	445	6	,	,	PUNCT
dti-1407	445	7	okano	okano	VERB
dti-1407	445	8	a	a	PRON
dti-1407	445	9	,	,	PUNCT
dti-1407	445	10	et	et	PROPN
dti-1407	445	11	al	al	PROPN
dti-1407	445	12	.	.	PUNCT
dti-1407	445	13	evaluation	evaluation	NOUN
dti-1407	445	14	of	of	ADP
dti-1407	445	15	antivascular	antivascular	ADJ
dti-1407	445	16	and	and	CCONJ
dti-1407	445	17	antimitotic	antimitotic	ADJ
dti-1407	445	18	effects	effect	NOUN
dti-1407	445	19	of	of	ADP
dti-1407	445	20	tubulin	tubulin	NOUN
dti-1407	445	21	binding	bind	VERB
dti-1407	445	22	agents	agent	NOUN
dti-1407	445	23	in	in	ADP
dti-1407	445	24	solid	solid	ADJ
dti-1407	445	25	tumor	tumor	NOUN
dti-1407	445	26	therapy	therapy	NOUN
dti-1407	445	27	.	.	PUNCT
dti-1407	446	1	jpn	jpn	PROPN
dti-1407	446	2	j	j	PROPN
dti-1407	446	3	cancer	cancer	NOUN
dti-1407	446	4	res	re	NOUN
dti-1407	446	5	.	.	PUNCT
dti-1407	446	6	1999	1999	NUM
dti-1407	446	7	;	;	PUNCT
dti-1407	447	1	90(12):1387–1395	90(12):1387–1395	NUM
dti-1407	447	2	.	.	PUNCT
dti-1407	447	3	http://www.la-press.com	http://www.la-press.com	X
dti-1407	448	1	http://www.la-press.com/drug-target-insights-journal-j23	http://www.la-press.com/drug-target-insights-journal-j23	PROPN
dti-1407	448	2	19drug	19drug	NUM
dti-1407	448	3	target	target	NOUN
dti-1407	448	4	insights	insight	VERB
dti-1407	448	5	2015:9	2015:9	PRON
dti-1407	448	6	medicinal	medicinal	ADJ
dti-1407	448	7	plants	plant	NOUN
dti-1407	448	8	:	:	PUNCT
dti-1407	448	9	a	a	DET
dti-1407	448	10	potential	potential	ADJ
dti-1407	448	11	source	source	NOUN
dti-1407	448	12	of	of	ADP
dti-1407	448	13	compounds	compound	NOUN
dti-1407	448	14	for	for	ADP
dti-1407	448	15	targeting	target	VERB
dti-1407	448	16	cell	cell	NOUN
dti-1407	448	17	division	division	NOUN
dti-1407	448	18	65	65	NUM
dti-1407	448	19	.	.	PUNCT
dti-1407	449	1	mooney	mooney	PROPN
dti-1407	449	2	cj	cj	PROPN
dti-1407	449	3	,	,	PUNCT
dti-1407	449	4	nagaiah	nagaiah	PROPN
dti-1407	449	5	g	g	PROPN
dti-1407	449	6	,	,	PUNCT
dti-1407	449	7	fu	fu	PROPN
dti-1407	449	8	p	p	NOUN
dti-1407	449	9	,	,	PUNCT
dti-1407	449	10	et	et	PROPN
dti-1407	449	11	al	al	PROPN
dti-1407	449	12	.	.	PUNCT
dti-1407	450	1	a	a	DET
dti-1407	450	2	phase	phase	NOUN
dti-1407	450	3	ii	ii	NOUN
dti-1407	450	4	trial	trial	NOUN
dti-1407	450	5	of	of	ADP
dti-1407	450	6	fosbretabulin	fosbretabulin	NOUN
dti-1407	450	7	in	in	ADP
dti-1407	450	8	advanced	advanced	ADJ
dti-1407	450	9	anaplastic	anaplastic	ADJ
dti-1407	450	10	thyroid	thyroid	NOUN
dti-1407	450	11	carcinoma	carcinoma	NOUN
dti-1407	450	12	and	and	CCONJ
dti-1407	450	13	correlation	correlation	NOUN
dti-1407	450	14	of	of	ADP
dti-1407	450	15	baseline	baseline	ADJ
dti-1407	450	16	serum	serum	NOUN
dti-1407	450	17	-	-	PUNCT
dti-1407	450	18	soluble	soluble	ADJ
dti-1407	450	19	intracellular	intracellular	ADJ
dti-1407	450	20	adhesion	adhesion	NOUN
dti-1407	450	21	molecule-1	molecule-1	PROPN
dti-1407	450	22	with	with	ADP
dti-1407	450	23	outcome	outcome	NOUN
dti-1407	450	24	.	.	PUNCT
dti-1407	451	1	thyroid	thyroid	NOUN
dti-1407	451	2	.	.	PUNCT
dti-1407	452	1	2009;19(3):233–240	2009;19(3):233–240	NUM
dti-1407	452	2	.	.	PROPN
dti-1407	452	3	66	66	NUM
dti-1407	452	4	.	.	PUNCT
dti-1407	453	1	subbiah	subbiah	PROPN
dti-1407	453	2	i	i	PRON
dti-1407	453	3	m	m	PROPN
dti-1407	453	4	,	,	PUNCT
dti-1407	453	5	lenihan	lenihan	PROPN
dti-1407	453	6	dj	dj	PROPN
dti-1407	453	7	,	,	PUNCT
dti-1407	453	8	tsimberidou	tsimberidou	PROPN
dti-1407	453	9	am	be	AUX
dti-1407	453	10	.	.	PUNCT
dti-1407	454	1	cardiovascular	cardiovascular	ADJ
dti-1407	454	2	toxicity	toxicity	NOUN
dti-1407	454	3	profiles	profile	NOUN
dti-1407	454	4	of	of	ADP
dti-1407	454	5	vascular	vascular	NOUN
dti-1407	454	6	-	-	PUNCT
dti-1407	454	7	disrupting	disrupt	VERB
dti-1407	454	8	agents	agent	NOUN
dti-1407	454	9	.	.	PUNCT
dti-1407	455	1	oncologist	oncologist	NOUN
dti-1407	455	2	.	.	PUNCT
dti-1407	456	1	2011;16(8):1120–1130	2011;16(8):1120–1130	PROPN
dti-1407	456	2	.	.	PUNCT
dti-1407	457	1	67	67	NUM
dti-1407	457	2	.	.	PUNCT
dti-1407	458	1	grossmann	grossmann	PROPN
dti-1407	458	2	kf	kf	PROPN
dti-1407	458	3	,	,	PUNCT
dti-1407	458	4	colman	colman	PROPN
dti-1407	458	5	h	h	PROPN
dti-1407	458	6	,	,	PUNCT
dti-1407	458	7	akerley	akerley	PROPN
dti-1407	458	8	wa	wa	PROPN
dti-1407	458	9	,	,	PUNCT
dti-1407	458	10	et	et	PROPN
dti-1407	458	11	al	al	PROPN
dti-1407	458	12	.	.	PROPN
dti-1407	458	13	phase	phase	NOUN
dti-1407	458	14	i	i	PRON
dti-1407	458	15	trial	trial	NOUN
dti-1407	458	16	of	of	ADP
dti-1407	458	17	verubulin	verubulin	PROPN
dti-1407	458	18	(	(	PUNCT
dti-1407	458	19	mpc6827	mpc6827	NOUN
dti-1407	458	20	)	)	PUNCT
dti-1407	458	21	plus	plus	CCONJ
dti-1407	458	22	carboplatin	carboplatin	NOUN
dti-1407	458	23	in	in	ADP
dti-1407	458	24	patients	patient	NOUN
dti-1407	458	25	with	with	ADP
dti-1407	458	26	relapsed	relapse	VERB
dti-1407	458	27	glioblastoma	glioblastoma	NOUN
dti-1407	458	28	multiforme	multiforme	NOUN
dti-1407	458	29	.	.	PUNCT
dti-1407	459	1	j	j	PROPN
dti-1407	459	2	neurooncol	neurooncol	PROPN
dti-1407	459	3	.	.	PUNCT
dti-1407	460	1	2012;110(2):257–264	2012;110(2):257–264	NUM
dti-1407	460	2	.	.	NUM
dti-1407	461	1	68	68	NUM
dti-1407	461	2	.	.	PUNCT
dti-1407	462	1	mahal	mahal	PROPN
dti-1407	462	2	k	k	PROPN
dti-1407	462	3	,	,	PUNCT
dti-1407	462	4	resch	resch	PROPN
dti-1407	462	5	m	m	PROPN
dti-1407	462	6	,	,	PUNCT
dti-1407	462	7	ficner	ficner	PROPN
dti-1407	462	8	r	r	NOUN
dti-1407	462	9	,	,	PUNCT
dti-1407	462	10	schobert	schobert	NOUN
dti-1407	462	11	r	r	NOUN
dti-1407	462	12	,	,	PUNCT
dti-1407	462	13	biersack	biersack	PROPN
dti-1407	462	14	b	b	PROPN
dti-1407	462	15	,	,	PUNCT
dti-1407	462	16	mueller	mueller	PROPN
dti-1407	462	17	t.	t.	PROPN
dti-1407	462	18	effects	effect	NOUN
dti-1407	462	19	of	of	ADP
dti-1407	462	20	the	the	DET
dti-1407	462	21	tumor	tumor	NOUN
dti-1407	462	22	-	-	PUNCT
dti-1407	462	23	vasculature	vasculature	NOUN
dti-1407	462	24	-	-	PUNCT
dti-1407	462	25	disrupting	disrupt	VERB
dti-1407	462	26	agent	agent	NOUN
dti-1407	462	27	verubulin	verubulin	NOUN
dti-1407	462	28	and	and	CCONJ
dti-1407	462	29	two	two	NUM
dti-1407	462	30	heteroaryl	heteroaryl	NOUN
dti-1407	462	31	analogues	analogue	NOUN
dti-1407	462	32	on	on	ADP
dti-1407	462	33	cancer	cancer	NOUN
dti-1407	462	34	cells	cell	NOUN
dti-1407	462	35	,	,	PUNCT
dti-1407	462	36	endothelial	endothelial	ADJ
dti-1407	462	37	cells	cell	NOUN
dti-1407	462	38	,	,	PUNCT
dti-1407	462	39	and	and	CCONJ
dti-1407	462	40	blood	blood	NOUN
dti-1407	462	41	vessels	vessel	NOUN
dti-1407	462	42	.	.	PUNCT
dti-1407	463	1	chem	chem	NOUN
dti-1407	463	2	med	med	ADJ
dti-1407	463	3	chem	chem	NOUN
dti-1407	463	4	.	.	PUNCT
dti-1407	464	1	2014;9(4):847–854	2014;9(4):847–854	X
dti-1407	464	2	.	.	PUNCT
dti-1407	464	3	http://www.la-press.com/drug-target-insights-journal-j23	http://www.la-press.com/drug-target-insights-journal-j23	PROPN
dti-1407	464	4	http://www.la-press.com	http://www.la-press.com	X