id sid tid token lemma pos dti-1408 1 1 21drug 21drug NUM dti-1408 1 2 target target NOUN dti-1408 1 3 insights insight NOUN dti-1408 1 4 2015:9 2015:9 NUM dti-1408 1 5 basal basal ADJ dti-1408 1 6 plasma plasma NOUN dti-1408 1 7 levels level NOUN dti-1408 1 8 of of ADP dti-1408 1 9 copeptin copeptin NOUN dti-1408 1 10 are be AUX dti-1408 1 11 elevated elevate VERB dti-1408 1 12 in in ADP dti-1408 1 13 inactive inactive ADJ dti-1408 1 14 inflammatory inflammatory ADJ dti-1408 1 15 bowel bowel NOUN dti-1408 1 16 disease disease NOUN dti-1408 1 17 after after ADP dti-1408 1 18 bowel bowel NOUN dti-1408 1 19 resection resection NOUN dti-1408 1 20 bodil bodil PROPN dti-1408 1 21 ohlsson ohlsson PROPN dti-1408 1 22 and and CCONJ dti-1408 1 23 olle olle PROPN dti-1408 1 24 melander melander PROPN dti-1408 1 25 department department PROPN dti-1408 1 26 of of ADP dti-1408 1 27 clinical clinical ADJ dti-1408 1 28 sciences science NOUN dti-1408 1 29 , , PUNCT dti-1408 1 30 section section NOUN dti-1408 1 31 of of ADP dti-1408 1 32 internal internal ADJ dti-1408 1 33 medicine medicine NOUN dti-1408 1 34 , , PUNCT dti-1408 1 35 skåne skåne PROPN dti-1408 1 36 university university PROPN dti-1408 1 37 hospital hospital NOUN dti-1408 1 38 , , PUNCT dti-1408 1 39 malmö malmö PROPN dti-1408 1 40 , , PUNCT dti-1408 1 41 and and CCONJ dti-1408 1 42 lund lund PROPN dti-1408 1 43 university university PROPN dti-1408 1 44 , , PUNCT dti-1408 1 45 lund lund PROPN dti-1408 1 46 , , PUNCT dti-1408 1 47 sweden sweden PROPN dti-1408 1 48 . . PROPN dti-1408 2 1 abstr abstr PROPN dti-1408 2 2 act act PROPN dti-1408 2 3 : : PUNCT dti-1408 2 4 evidence evidence NOUN dti-1408 2 5 of of ADP dti-1408 2 6 interactions interaction NOUN dti-1408 2 7 between between ADP dti-1408 2 8 the the DET dti-1408 2 9 enteric enteric ADJ dti-1408 2 10 nervous nervous ADJ dti-1408 2 11 system system NOUN dti-1408 2 12 , , PUNCT dti-1408 2 13 neuropeptides neuropeptide NOUN dti-1408 2 14 , , PUNCT dti-1408 2 15 and and CCONJ dti-1408 2 16 the the DET dti-1408 2 17 immune immune ADJ dti-1408 2 18 system system NOUN dti-1408 2 19 is be AUX dti-1408 2 20 growing grow VERB dti-1408 2 21 . . PUNCT dti-1408 3 1 the the DET dti-1408 3 2 aim aim NOUN dti-1408 3 3 of of ADP dti-1408 3 4 this this DET dti-1408 3 5 study study NOUN dti-1408 3 6 was be AUX dti-1408 3 7 to to PART dti-1408 3 8 examine examine VERB dti-1408 3 9 basal basal ADJ dti-1408 3 10 plasma plasma NOUN dti-1408 3 11 levels level NOUN dti-1408 3 12 of of ADP dti-1408 3 13 a a DET dti-1408 3 14 variety variety NOUN dti-1408 3 15 of of ADP dti-1408 3 16 peptide peptide ADJ dti-1408 3 17 precursors precursor NOUN dti-1408 3 18 in in ADP dti-1408 3 19 patients patient NOUN dti-1408 3 20 with with ADP dti-1408 3 21 inflammatory inflammatory ADJ dti-1408 3 22 bowel bowel NOUN dti-1408 3 23 disease disease NOUN dti-1408 3 24 ( ( PUNCT dti-1408 3 25 ibd ibd PROPN dti-1408 3 26 ) ) PUNCT dti-1408 3 27 . . PUNCT dti-1408 4 1 in in ADP dti-1408 4 2 two two NUM dti-1408 4 3 middle middle ADJ dti-1408 4 4 - - PUNCT dti-1408 4 5 aged aged ADJ dti-1408 4 6 cohorts cohort NOUN dti-1408 4 7 , , PUNCT dti-1408 4 8 malmö malmö PROPN dti-1408 4 9 preventive preventive ADJ dti-1408 4 10 medicine medicine NOUN dti-1408 4 11 ( ( PUNCT dti-1408 4 12 n n NOUN dti-1408 4 13 = = SYM dti-1408 4 14 5,415 5,415 NUM dti-1408 4 15 ) ) PUNCT dti-1408 4 16 and and CCONJ dti-1408 4 17 malmö malmö PROPN dti-1408 4 18 diet diet PROPN dti-1408 4 19 and and CCONJ dti-1408 4 20 cost cost NOUN dti-1408 4 21 study study NOUN dti-1408 4 22 ( ( PUNCT dti-1408 4 23 n n NOUN dti-1408 4 24 = = SYM dti-1408 4 25 6,103 6,103 NUM dti-1408 4 26 ) ) PUNCT dti-1408 4 27 , , PUNCT dti-1408 4 28 individuals individual NOUN dti-1408 4 29 with with ADP dti-1408 4 30 the the DET dti-1408 4 31 diagnosis diagnosis NOUN dti-1408 4 32 of of ADP dti-1408 4 33 ibd ibd NOUN dti-1408 4 34 were be AUX dti-1408 4 35 identified identify VERB dti-1408 4 36 . . PUNCT dti-1408 5 1 medical medical ADJ dti-1408 5 2 records record NOUN dti-1408 5 3 were be AUX dti-1408 5 4 scrutinized scrutinize VERB dti-1408 5 5 . . PUNCT dti-1408 6 1 three three NUM dti-1408 6 2 controls control NOUN dti-1408 6 3 were be AUX dti-1408 6 4 matched match VERB dti-1408 6 5 for for ADP dti-1408 6 6 each each DET dti-1408 6 7 patient patient NOUN dti-1408 6 8 . . PUNCT dti-1408 7 1 copeptin copeptin NOUN dti-1408 7 2 , , PUNCT dti-1408 7 3 midregional midregional ADJ dti-1408 7 4 fragments fragment NOUN dti-1408 7 5 of of ADP dti-1408 7 6 adrenomedullin adrenomedullin NOUN dti-1408 7 7 , , PUNCT dti-1408 7 8 pro pro ADJ dti-1408 7 9 - - ADJ dti-1408 7 10 atrial atrial ADJ dti-1408 7 11 natriuretic natriuretic ADJ dti-1408 7 12 peptide peptide NOUN dti-1408 7 13 , , PUNCT dti-1408 7 14 and and CCONJ dti-1408 7 15 proenkephalin proenkephalin PROPN dti-1408 7 16 a a PRON dti-1408 7 17 , , PUNCT dti-1408 7 18 as as ADV dti-1408 7 19 well well ADV dti-1408 7 20 as as ADP dti-1408 7 21 n n NOUN dti-1408 7 22 - - PUNCT dti-1408 7 23 terminal terminal ADJ dti-1408 7 24 protachykinin protachykinin NOUN dti-1408 7 25 a a DET dti-1408 7 26 and and CCONJ dti-1408 7 27 proneurotensin proneurotensin NOUN dti-1408 7 28 were be AUX dti-1408 7 29 analyzed analyze VERB dti-1408 7 30 in in ADP dti-1408 7 31 the the DET dti-1408 7 32 plasma plasma NOUN dti-1408 7 33 . . PUNCT dti-1408 8 1 sixty sixty NUM dti-1408 8 2 - - PUNCT dti-1408 8 3 two two NUM dti-1408 8 4 ibd ibd NOUN dti-1408 8 5 patients patient NOUN dti-1408 8 6 were be AUX dti-1408 8 7 identified identify VERB dti-1408 8 8 . . PUNCT dti-1408 9 1 the the DET dti-1408 9 2 only only ADJ dti-1408 9 3 difference difference NOUN dti-1408 9 4 between between ADP dti-1408 9 5 patients patient NOUN dti-1408 9 6 and and CCONJ dti-1408 9 7 controls control NOUN dti-1408 9 8 was be AUX dti-1408 9 9 higher high ADJ dti-1408 9 10 copeptin copeptin NOUN dti-1408 9 11 levels level NOUN dti-1408 9 12 in in ADP dti-1408 9 13 the the DET dti-1408 9 14 patients patient NOUN dti-1408 9 15 compared compare VERB dti-1408 9 16 with with ADP dti-1408 9 17 controls control NOUN dti-1408 9 18 ( ( PUNCT dti-1408 9 19 p p X dti-1408 9 20 = = NOUN dti-1408 9 21 0.006 0.006 NUM dti-1408 9 22 ) ) PUNCT dti-1408 9 23 , , PUNCT dti-1408 9 24 with with ADP dti-1408 9 25 higher high ADJ dti-1408 9 26 copeptin copeptin NOUN dti-1408 9 27 levels level NOUN dti-1408 9 28 in in ADP dti-1408 9 29 resected resect VERB dti-1408 9 30 than than ADP dti-1408 9 31 unresected unresected ADJ dti-1408 9 32 patients patient NOUN dti-1408 9 33 ( ( PUNCT dti-1408 9 34 p p X dti-1408 9 35 = = NOUN dti-1408 9 36 0.020 0.020 NUM dti-1408 9 37 ) ) PUNCT dti-1408 9 38 . . PUNCT dti-1408 10 1 there there PRON dti-1408 10 2 was be VERB dti-1408 10 3 no no DET dti-1408 10 4 difference difference NOUN dti-1408 10 5 in in ADP dti-1408 10 6 any any DET dti-1408 10 7 precursor precursor NOUN dti-1408 10 8 levels level NOUN dti-1408 10 9 between between ADP dti-1408 10 10 crohn crohn PROPN dti-1408 10 11 ’s ’s PART dti-1408 10 12 disease disease NOUN dti-1408 10 13 and and CCONJ dti-1408 10 14 ulcerative ulcerative ADJ dti-1408 10 15 colitis colitis NOUN dti-1408 10 16 , , PUNCT dti-1408 10 17 between between ADP dti-1408 10 18 different different ADJ dti-1408 10 19 distributions distribution NOUN dti-1408 10 20 of of ADP dti-1408 10 21 disease disease NOUN dti-1408 10 22 lesions lesion NOUN dti-1408 10 23 , , PUNCT dti-1408 10 24 or or CCONJ dti-1408 10 25 between between ADP dti-1408 10 26 different different ADJ dti-1408 10 27 treatments treatment NOUN dti-1408 10 28 . . PUNCT dti-1408 11 1 key key ADJ dti-1408 11 2 words word NOUN dti-1408 11 3 : : PUNCT dti-1408 11 4 copeptin copeptin NOUN dti-1408 11 5 , , PUNCT dti-1408 11 6 inflammatory inflammatory ADJ dti-1408 11 7 bowel bowel NOUN dti-1408 11 8 disease disease NOUN dti-1408 11 9 , , PUNCT dti-1408 11 10 irritable irritable ADJ dti-1408 11 11 bowel bowel NOUN dti-1408 11 12 syndrome syndrome NOUN dti-1408 11 13 - - PUNCT dti-1408 11 14 like like ADJ dti-1408 11 15 symptoms symptom NOUN dti-1408 11 16 , , PUNCT dti-1408 11 17 neuropeptides neuropeptide NOUN dti-1408 11 18 , , PUNCT dti-1408 11 19 precursors precursor NOUN dti-1408 11 20 citation citation NOUN dti-1408 11 21 : : PUNCT dti-1408 11 22 ohlsson ohlsson NOUN dti-1408 11 23 and and CCONJ dti-1408 11 24 melander melander NOUN dti-1408 11 25 . . PUNCT dti-1408 12 1 basal basal ADJ dti-1408 12 2 plasma plasma NOUN dti-1408 12 3 levels level NOUN dti-1408 12 4 of of ADP dti-1408 12 5 copeptin copeptin NOUN dti-1408 12 6 are be AUX dti-1408 12 7 elevated elevate VERB dti-1408 12 8 in in ADP dti-1408 12 9 inactive inactive ADJ dti-1408 12 10 inflammatory inflammatory ADJ dti-1408 12 11 bowel bowel NOUN dti-1408 12 12 disease disease NOUN dti-1408 12 13 after after ADP dti-1408 12 14 bowel bowel NOUN dti-1408 12 15 resection resection NOUN dti-1408 12 16 . . PUNCT dti-1408 13 1 drug drug NOUN dti-1408 13 2 target target NOUN dti-1408 13 3 insights insight VERB dti-1408 13 4 2015:9 2015:9 NUM dti-1408 13 5 21–27 21–27 NUM dti-1408 13 6 doi:10.4137 doi:10.4137 NOUN dti-1408 13 7 / / SYM dti-1408 13 8 dti.s26589 dti.s26589 NOUN dti-1408 13 9 . . PUNCT dti-1408 14 1 received receive VERB dti-1408 14 2 : : PUNCT dti-1408 14 3 march march PROPN dti-1408 14 4 24 24 NUM dti-1408 14 5 , , PUNCT dti-1408 14 6 2015 2015 NUM dti-1408 14 7 . . PUNCT dti-1408 15 1 resubmitted resubmitte VERB dti-1408 15 2 : : PUNCT dti-1408 15 3 june june PROPN dti-1408 15 4 1 1 NUM dti-1408 15 5 , , PUNCT dti-1408 15 6 2015 2015 NUM dti-1408 15 7 . . PUNCT dti-1408 16 1 accepted accept VERB dti-1408 16 2 for for ADP dti-1408 16 3 publication publication NOUN dti-1408 16 4 : : PUNCT dti-1408 16 5 june june PROPN dti-1408 16 6 3 3 NUM dti-1408 16 7 , , PUNCT dti-1408 16 8 2015 2015 NUM dti-1408 16 9 . . PUNCT dti-1408 17 1 academic academic ADJ dti-1408 17 2 editor editor NOUN dti-1408 17 3 : : PUNCT dti-1408 17 4 anuj anuj PROPN dti-1408 17 5 chauhan chauhan PROPN dti-1408 17 6 , , PUNCT dti-1408 17 7 editor editor NOUN dti-1408 17 8 in in ADP dti-1408 17 9 chief chief ADJ dti-1408 17 10 type type NOUN dti-1408 17 11 : : PUNCT dti-1408 17 12 original original ADJ dti-1408 17 13 research research NOUN dti-1408 17 14 funding funding NOUN dti-1408 17 15 : : PUNCT dti-1408 17 16 this this DET dti-1408 17 17 work work NOUN dti-1408 17 18 was be AUX dti-1408 17 19 supported support VERB dti-1408 17 20 by by ADP dti-1408 17 21 the the DET dti-1408 17 22 bengt bengt PROPN dti-1408 17 23 ihre ihre PROPN dti-1408 17 24 foundation foundation PROPN dti-1408 17 25 , , PUNCT dti-1408 17 26 dir dir PROPN dti-1408 17 27 . . PUNCT dti-1408 18 1 albert albert PROPN dti-1408 18 2 påhlsson påhlsson PROPN dti-1408 18 3 foundation foundation PROPN dti-1408 18 4 , , PUNCT dti-1408 18 5 foundation foundation PROPN dti-1408 18 6 of of ADP dti-1408 18 7 skåne skåne PROPN dti-1408 18 8 university university PROPN dti-1408 18 9 hospital hospital NOUN dti-1408 18 10 , , PUNCT dti-1408 18 11 and and CCONJ dti-1408 18 12 the the DET dti-1408 18 13 development development NOUN dti-1408 18 14 foundation foundation PROPN dti-1408 18 15 of of ADP dti-1408 18 16 region region NOUN dti-1408 18 17 skåne skåne PROPN dti-1408 18 18 . . PUNCT dti-1408 19 1 the the DET dti-1408 19 2 authors author NOUN dti-1408 19 3 confirm confirm VERB dti-1408 19 4 that that SCONJ dti-1408 19 5 the the DET dti-1408 19 6 funder funder NOUN dti-1408 19 7 had have VERB dti-1408 19 8 no no DET dti-1408 19 9 influence influence NOUN dti-1408 19 10 over over ADP dti-1408 19 11 the the DET dti-1408 19 12 study study NOUN dti-1408 19 13 design design NOUN dti-1408 19 14 , , PUNCT dti-1408 19 15 content content NOUN dti-1408 19 16 of of ADP dti-1408 19 17 the the DET dti-1408 19 18 article article NOUN dti-1408 19 19 , , PUNCT dti-1408 19 20 or or CCONJ dti-1408 19 21 selection selection NOUN dti-1408 19 22 of of ADP dti-1408 19 23 this this DET dti-1408 19 24 journal journal NOUN dti-1408 19 25 . . PUNCT dti-1408 20 1 competing compete VERB dti-1408 20 2 interests interest NOUN dti-1408 20 3 : : PUNCT dti-1408 20 4 authors author NOUN dti-1408 20 5 disclose disclose VERB dti-1408 20 6 no no DET dti-1408 20 7 potential potential ADJ dti-1408 20 8 conflicts conflict NOUN dti-1408 20 9 of of ADP dti-1408 20 10 interest interest NOUN dti-1408 20 11 . . PUNCT dti-1408 21 1 copyright copyright NOUN dti-1408 21 2 : : PUNCT dti-1408 21 3 © © PROPN dti-1408 21 4 the the DET dti-1408 21 5 authors author NOUN dti-1408 21 6 , , PUNCT dti-1408 21 7 publisher publisher NOUN dti-1408 21 8 and and CCONJ dti-1408 21 9 licensee licensee NOUN dti-1408 21 10 libertas liberta NOUN dti-1408 21 11 academica academica PROPN dti-1408 21 12 limited limit VERB dti-1408 21 13 . . PUNCT dti-1408 22 1 this this PRON dti-1408 22 2 is be AUX dti-1408 22 3 an an DET dti-1408 22 4 open open ADJ dti-1408 22 5 - - PUNCT dti-1408 22 6 access access NOUN dti-1408 22 7 article article NOUN dti-1408 22 8 distributed distribute VERB dti-1408 22 9 under under ADP dti-1408 22 10 the the DET dti-1408 22 11 terms term NOUN dti-1408 22 12 of of ADP dti-1408 22 13 the the DET dti-1408 22 14 creative creative ADJ dti-1408 22 15 commons common NOUN dti-1408 22 16 cc cc NOUN dti-1408 22 17 - - PUNCT dti-1408 22 18 by by ADP dti-1408 22 19 - - PUNCT dti-1408 22 20 nc nc PROPN dti-1408 22 21 3.0 3.0 NUM dti-1408 22 22 license license NOUN dti-1408 22 23 . . PUNCT dti-1408 23 1 correspondence correspondence NOUN dti-1408 23 2 : : PUNCT dti-1408 23 3 bodil.ohlsson@med.lu.se bodil.ohlsson@med.lu.se NOUN dti-1408 23 4 paper paper PROPN dti-1408 23 5 subject subject NOUN dti-1408 23 6 to to ADP dti-1408 23 7 independent independent ADJ dti-1408 23 8 expert expert NOUN dti-1408 23 9 blind blind ADJ dti-1408 23 10 peer peer NOUN dti-1408 23 11 review review NOUN dti-1408 23 12 by by ADP dti-1408 23 13 minimum minimum NOUN dti-1408 23 14 of of ADP dti-1408 23 15 two two NUM dti-1408 23 16 reviewers reviewer NOUN dti-1408 23 17 . . PUNCT dti-1408 24 1 all all DET dti-1408 24 2 editorial editorial ADJ dti-1408 24 3 decisions decision NOUN dti-1408 24 4 made make VERB dti-1408 24 5 by by ADP dti-1408 24 6 independent independent ADJ dti-1408 24 7 academic academic ADJ dti-1408 24 8 editor editor NOUN dti-1408 24 9 . . PUNCT dti-1408 25 1 upon upon SCONJ dti-1408 25 2 submission submission NOUN dti-1408 25 3 manuscript manuscript NOUN dti-1408 25 4 was be AUX dti-1408 25 5 subject subject ADJ dti-1408 25 6 to to ADP dti-1408 25 7 anti anti ADJ dti-1408 25 8 - - NOUN dti-1408 25 9 plagiarism plagiarism ADJ dti-1408 25 10 scanning scanning NOUN dti-1408 25 11 . . PUNCT dti-1408 26 1 prior prior ADV dti-1408 26 2 to to ADP dti-1408 26 3 publication publication NOUN dti-1408 26 4 all all DET dti-1408 26 5 authors author NOUN dti-1408 26 6 have have AUX dti-1408 26 7 given give VERB dti-1408 26 8 signed sign VERB dti-1408 26 9 confirmation confirmation NOUN dti-1408 26 10 of of ADP dti-1408 26 11 agreement agreement NOUN dti-1408 26 12 to to ADP dti-1408 26 13 article article NOUN dti-1408 26 14 publication publication NOUN dti-1408 26 15 and and CCONJ dti-1408 26 16 compliance compliance NOUN dti-1408 26 17 with with ADP dti-1408 26 18 all all DET dti-1408 26 19 applicable applicable ADJ dti-1408 26 20 ethical ethical ADJ dti-1408 26 21 and and CCONJ dti-1408 26 22 legal legal ADJ dti-1408 26 23 requirements requirement NOUN dti-1408 26 24 , , PUNCT dti-1408 26 25 including include VERB dti-1408 26 26 the the DET dti-1408 26 27 accuracy accuracy NOUN dti-1408 26 28 of of ADP dti-1408 26 29 author author NOUN dti-1408 26 30 and and CCONJ dti-1408 26 31 contributor contributor NOUN dti-1408 26 32 information information NOUN dti-1408 26 33 , , PUNCT dti-1408 26 34 disclosure disclosure NOUN dti-1408 26 35 of of ADP dti-1408 26 36 competing compete VERB dti-1408 26 37 interests interest NOUN dti-1408 26 38 and and CCONJ dti-1408 26 39 funding funding NOUN dti-1408 26 40 sources source NOUN dti-1408 26 41 , , PUNCT dti-1408 26 42 compliance compliance NOUN dti-1408 26 43 with with ADP dti-1408 26 44 ethical ethical ADJ dti-1408 26 45 requirements requirement NOUN dti-1408 26 46 relating relate VERB dti-1408 26 47 to to ADP dti-1408 26 48 human human ADJ dti-1408 26 49 and and CCONJ dti-1408 26 50 animal animal NOUN dti-1408 26 51 study study NOUN dti-1408 26 52 participants participant NOUN dti-1408 26 53 , , PUNCT dti-1408 26 54 and and CCONJ dti-1408 26 55 compliance compliance NOUN dti-1408 26 56 with with ADP dti-1408 26 57 any any DET dti-1408 26 58 copyright copyright NOUN dti-1408 26 59 requirements requirement NOUN dti-1408 26 60 of of ADP dti-1408 26 61 third third ADJ dti-1408 26 62 parties party NOUN dti-1408 26 63 . . PUNCT dti-1408 27 1 this this DET dti-1408 27 2 journal journal NOUN dti-1408 27 3 is be AUX dti-1408 27 4 a a DET dti-1408 27 5 member member NOUN dti-1408 27 6 of of ADP dti-1408 27 7 the the DET dti-1408 27 8 committee committee NOUN dti-1408 27 9 on on ADP dti-1408 27 10 publication publication NOUN dti-1408 27 11 ethics ethic NOUN dti-1408 27 12 ( ( PUNCT dti-1408 27 13 cope cope PROPN dti-1408 27 14 ) ) PUNCT dti-1408 27 15 . . PUNCT dti-1408 28 1 published publish VERB dti-1408 28 2 by by ADP dti-1408 28 3 libertas liberta NOUN dti-1408 28 4 academica academica PROPN dti-1408 28 5 . . PUNCT dti-1408 29 1 learn learn VERB dti-1408 29 2 more more ADJ dti-1408 29 3 about about ADP dti-1408 29 4 this this DET dti-1408 29 5 journal journal NOUN dti-1408 29 6 . . PUNCT dti-1408 30 1 introduction introduction NOUN dti-1408 30 2 interactions interaction NOUN dti-1408 30 3 between between ADP dti-1408 30 4 the the DET dti-1408 30 5 enteric enteric ADJ dti-1408 30 6 nervous nervous ADJ dti-1408 30 7 system system NOUN dti-1408 30 8 ( ( PUNCT dti-1408 30 9 ens ens PROPN dti-1408 30 10 ) ) PUNCT dti-1408 30 11 and and CCONJ dti-1408 30 12 the the DET dti-1408 30 13 immune immune ADJ dti-1408 30 14 system system NOUN dti-1408 30 15 have have AUX dti-1408 30 16 been be AUX dti-1408 30 17 the the DET dti-1408 30 18 subject subject NOUN dti-1408 30 19 of of ADP dti-1408 30 20 much much ADJ dti-1408 30 21 new new ADJ dti-1408 30 22 evidence evidence NOUN dti-1408 30 23 in in ADP dti-1408 30 24 recent recent ADJ dti-1408 30 25 years year NOUN dti-1408 30 26 . . PUNCT dti-1408 31 1 inflammatory inflammatory ADJ dti-1408 31 2 cells cell NOUN dti-1408 31 3 in in ADP dti-1408 31 4 the the DET dti-1408 31 5 intestine intestine NOUN dti-1408 31 6 express express ADJ dti-1408 31 7 receptors receptor NOUN dti-1408 31 8 for for ADP dti-1408 31 9 neuropeptides neuropeptide NOUN dti-1408 31 10 , , PUNCT dti-1408 31 11 and and CCONJ dti-1408 31 12 the the DET dti-1408 31 13 enteric enteric ADJ dti-1408 31 14 neurons neuron NOUN dti-1408 31 15 are be AUX dti-1408 31 16 responsive responsive ADJ dti-1408 31 17 to to ADP dti-1408 31 18 cytokines cytokine NOUN dti-1408 31 19 secreted secrete VERB dti-1408 31 20 from from ADP dti-1408 31 21 inflammatory inflammatory ADJ dti-1408 31 22 cells.1,2 cells.1,2 PROPN dti-1408 31 23 nevertheless nevertheless ADV dti-1408 31 24 , , PUNCT dti-1408 31 25 the the DET dti-1408 31 26 focus focus NOUN dti-1408 31 27 in in ADP dti-1408 31 28 inflammatory inflammatory ADJ dti-1408 31 29 bowel bowel NOUN dti-1408 31 30 disease disease NOUN dti-1408 31 31 ( ( PUNCT dti-1408 31 32 ibd ibd PROPN dti-1408 31 33 ) ) PUNCT dti-1408 31 34 has have AUX dti-1408 31 35 been be AUX dti-1408 31 36 the the DET dti-1408 31 37 immune immune ADJ dti-1408 31 38 system system NOUN dti-1408 31 39 , , PUNCT dti-1408 31 40 and and CCONJ dti-1408 31 41 few few ADJ dti-1408 31 42 studies study NOUN dti-1408 31 43 have have AUX dti-1408 31 44 examined examine VERB dti-1408 31 45 the the DET dti-1408 31 46 role role NOUN dti-1408 31 47 of of ADP dti-1408 31 48 neuropeptides neuropeptide NOUN dti-1408 31 49 in in ADP dti-1408 31 50 the the DET dti-1408 31 51 development development NOUN dti-1408 31 52 and and CCONJ dti-1408 31 53 maintenance maintenance NOUN dti-1408 31 54 of of ADP dti-1408 31 55 the the DET dti-1408 31 56 disease disease NOUN dti-1408 31 57 , , PUNCT dti-1408 31 58 especially especially ADV dti-1408 31 59 in in ADP dti-1408 31 60 inactive inactive ADJ dti-1408 31 61 disease disease NOUN dti-1408 31 62 . . PUNCT dti-1408 32 1 even even ADV dti-1408 32 2 when when SCONJ dti-1408 32 3 the the DET dti-1408 32 4 disease disease NOUN dti-1408 32 5 is be AUX dti-1408 32 6 under under ADP dti-1408 32 7 control control NOUN dti-1408 32 8 and and CCONJ dti-1408 32 9 no no DET dti-1408 32 10 signs sign NOUN dti-1408 32 11 of of ADP dti-1408 32 12 inflammation inflammation NOUN dti-1408 32 13 are be AUX dti-1408 32 14 present present ADJ dti-1408 32 15 , , PUNCT dti-1408 32 16 patients patient NOUN dti-1408 32 17 with with ADP dti-1408 32 18 ibd ibd PROPN dti-1408 32 19 often often ADV dti-1408 32 20 suffer suffer VERB dti-1408 32 21 from from ADP dti-1408 32 22 abdominal abdominal ADJ dti-1408 32 23 pain pain NOUN dti-1408 32 24 and and CCONJ dti-1408 32 25 functional functional ADJ dti-1408 32 26 abdominal abdominal ADJ dti-1408 32 27 complaints complaint NOUN dti-1408 32 28 , , PUNCT dti-1408 32 29 so so ADV dti-1408 32 30 - - PUNCT dti-1408 32 31 called call VERB dti-1408 32 32 irritable irritable ADJ dti-1408 32 33 bowel bowel NOUN dti-1408 32 34 syndrome syndrome NOUN dti-1408 32 35 ( ( PUNCT dti-1408 32 36 ibs)-like ibs)-like INTJ dti-1408 32 37 symptoms.3 symptoms.3 VERB dti-1408 32 38 the the DET dti-1408 32 39 reason reason NOUN dti-1408 32 40 for for ADP dti-1408 32 41 these these DET dti-1408 32 42 complaints complaint NOUN dti-1408 32 43 is be AUX dti-1408 32 44 unknown unknown ADJ dti-1408 32 45 , , PUNCT dti-1408 32 46 but but CCONJ dti-1408 32 47 hypersensitivity hypersensitivity NOUN dti-1408 32 48 , , PUNCT dti-1408 32 49 lowgrade lowgrade NOUN dti-1408 32 50 inflammation inflammation NOUN dti-1408 32 51 , , PUNCT dti-1408 32 52 or or CCONJ dti-1408 32 53 impaired impair VERB dti-1408 32 54 epithelial epithelial ADJ dti-1408 32 55 barrier barrier NOUN dti-1408 32 56 has have AUX dti-1408 32 57 been be AUX dti-1408 32 58 suggested.3 suggested.3 NOUN dti-1408 32 59 imbalance imbalance NOUN dti-1408 32 60 in in ADP dti-1408 32 61 neurotransmitters neurotransmitter NOUN dti-1408 32 62 / / SYM dti-1408 32 63 neuropeptides neuropeptide NOUN dti-1408 32 64 has have AUX dti-1408 32 65 only only ADV dti-1408 32 66 been be AUX dti-1408 32 67 sparsely sparsely ADV dti-1408 32 68 examined examine VERB dti-1408 32 69 in in ADP dti-1408 32 70 relation relation NOUN dti-1408 32 71 to to ADP dti-1408 32 72 hypersensitivity hypersensitivity NOUN dti-1408 32 73 and and CCONJ dti-1408 32 74 ibs ib NOUN dti-1408 32 75 - - PUNCT dti-1408 32 76 like like ADJ dti-1408 32 77 symptoms symptom NOUN dti-1408 32 78 . . PUNCT dti-1408 33 1 structural structural ADJ dti-1408 33 2 changes change NOUN dti-1408 33 3 occur occur VERB dti-1408 33 4 in in ADP dti-1408 33 5 the the DET dti-1408 33 6 ens ens NOUN dti-1408 33 7 during during ADP dti-1408 33 8 ibd,4 ibd,4 NOUN dti-1408 33 9 and and CCONJ dti-1408 33 10 the the DET dti-1408 33 11 precursor precursor NOUN dti-1408 33 12 mrnas mrna NOUN dti-1408 33 13 encoding encode VERB dti-1408 33 14 substance substance NOUN dti-1408 33 15 p p NOUN dti-1408 33 16 and and CCONJ dti-1408 33 17 related related ADJ dti-1408 33 18 receptors receptor NOUN dti-1408 33 19 have have AUX dti-1408 33 20 been be AUX dti-1408 33 21 found find VERB dti-1408 33 22 to to PART dti-1408 33 23 be be AUX dti-1408 33 24 upregulated upregulate VERB dti-1408 33 25 in in ADP dti-1408 33 26 crohn crohn PROPN dti-1408 33 27 ’s ’s PART dti-1408 33 28 disease.5,6 disease.5,6 VERB dti-1408 33 29 recently recently ADV dti-1408 33 30 , , PUNCT dti-1408 33 31 lower low ADJ dti-1408 33 32 plasma plasma NOUN dti-1408 33 33 levels level NOUN dti-1408 33 34 of of ADP dti-1408 33 35 enkephalins enkephalin NOUN dti-1408 33 36 were be AUX dti-1408 33 37 described describe VERB dti-1408 33 38 in in ADP dti-1408 33 39 active active ADJ dti-1408 33 40 ibd ibd NOUN dti-1408 33 41 patients patient NOUN dti-1408 33 42 compared compare VERB dti-1408 33 43 with with ADP dti-1408 33 44 controls.7 controls.7 PROPN dti-1408 33 45 adrenomedullin adrenomedullin PROPN dti-1408 33 46 , , PUNCT dti-1408 33 47 enkephalin enkephalin PROPN dti-1408 33 48 a a PROPN dti-1408 33 49 , , PUNCT dti-1408 33 50 neurotensin neurotensin NOUN dti-1408 33 51 , , PUNCT dti-1408 33 52 and and CCONJ dti-1408 33 53 substance substance NOUN dti-1408 33 54 p p NOUN dti-1408 33 55 , , PUNCT dti-1408 33 56 as as ADV dti-1408 33 57 well well ADV dti-1408 33 58 as as ADP dti-1408 33 59 their their PRON dti-1408 33 60 receptors receptor NOUN dti-1408 33 61 , , PUNCT dti-1408 33 62 have have AUX dti-1408 33 63 been be AUX dti-1408 33 64 demonstrated demonstrate VERB dti-1408 33 65 in in ADP dti-1408 33 66 the the DET dti-1408 33 67 gastrointestinal gastrointestinal ADJ dti-1408 33 68 tract2,8–11 tract2,8–11 NOUN dti-1408 33 69 and and CCONJ dti-1408 33 70 found find VERB dti-1408 33 71 to to PART dti-1408 33 72 be be AUX dti-1408 33 73 involved involve VERB dti-1408 33 74 in in ADP dti-1408 33 75 inflammation inflammation NOUN dti-1408 33 76 and and CCONJ dti-1408 33 77 nociception.10–14 nociception.10–14 PROPN dti-1408 33 78 adrenomedullin adrenomedullin NOUN dti-1408 33 79 has have AUX dti-1408 33 80 been be AUX dti-1408 33 81 shown show VERB dti-1408 33 82 to to PART dti-1408 33 83 ameliorate ameliorate VERB dti-1408 33 84 the the DET dti-1408 33 85 induction induction NOUN dti-1408 33 86 of of ADP dti-1408 33 87 colitis colitis NOUN dti-1408 33 88 in in ADP dti-1408 33 89 animal animal NOUN dti-1408 33 90 models model NOUN dti-1408 33 91 and and CCONJ dti-1408 33 92 to to PART dti-1408 33 93 induce induce VERB dti-1408 33 94 wound wound NOUN dti-1408 33 95 healing.10 healing.10 NOUN dti-1408 33 96 enkephalins enkephalin NOUN dti-1408 33 97 exert exert VERB dti-1408 33 98 both both PRON dti-1408 33 99 antiinflammatory antiinflammatory NOUN dti-1408 33 100 and and CCONJ dti-1408 33 101 anti anti ADJ dti-1408 33 102 - - ADJ dti-1408 33 103 nociceptive nociceptive ADJ dti-1408 33 104 effects effect NOUN dti-1408 33 105 in in ADP dti-1408 33 106 induced induced ADJ dti-1408 33 107 colitis colitis NOUN dti-1408 33 108 in in ADP dti-1408 33 109 animal animal NOUN dti-1408 33 110 models.13 models.13 PROPN dti-1408 33 111 endogenous endogenous ADJ dti-1408 33 112 neurotensin neurotensin NOUN dti-1408 33 113 facilitates facilitate VERB dti-1408 33 114 visceral visceral ADJ dti-1408 33 115 pain pain NOUN dti-1408 33 116 responses response NOUN dti-1408 33 117 and and CCONJ dti-1408 33 118 is be AUX dti-1408 33 119 necessary necessary ADJ dti-1408 33 120 for for SCONJ dti-1408 33 121 the the DET dti-1408 33 122 development development NOUN dti-1408 33 123 of of ADP dti-1408 33 124 irritantinduced irritantinduce VERB dti-1408 33 125 hyperalgesia.12 hyperalgesia.12 NOUN dti-1408 33 126 substance substance NOUN dti-1408 33 127 p p NOUN dti-1408 33 128 is be AUX dti-1408 33 129 involved involve VERB dti-1408 33 130 in in ADP dti-1408 33 131 the the DET dti-1408 33 132 regulation regulation NOUN dti-1408 33 133 of of ADP dti-1408 33 134 mast mast NOUN dti-1408 33 135 cell cell NOUN dti-1408 33 136 activation,14 activation,14 ADV dti-1408 33 137 and and CCONJ dti-1408 33 138 the the DET dti-1408 33 139 upregulation upregulation NOUN dti-1408 33 140 of of ADP dti-1408 33 141 substance substance NOUN dti-1408 33 142 p p NOUN dti-1408 33 143 observed observe VERB dti-1408 33 144 in in ADP dti-1408 33 145 the the DET dti-1408 33 146 gastrointestinal gastrointestinal ADJ dti-1408 33 147 tract tract NOUN dti-1408 33 148 in in ADP dti-1408 33 149 ibd ibd NOUN dti-1408 33 150 patients patient NOUN dti-1408 33 151 seems seem VERB dti-1408 33 152 to to PART dti-1408 33 153 be be AUX dti-1408 33 154 associated associate VERB dti-1408 33 155 with with ADP dti-1408 33 156 ongoing ongoing ADJ dti-1408 33 157 local local ADJ dti-1408 33 158 inflammation inflammation NOUN dti-1408 33 159 , , PUNCT dti-1408 33 160 which which PRON dti-1408 33 161 can can AUX dti-1408 33 162 be be AUX dti-1408 33 163 clinically clinically ADV dti-1408 33 164 quiet.11 quiet.11 ADJ dti-1408 33 165 copeptin copeptin NOUN dti-1408 33 166 , , PUNCT dti-1408 33 167 the the DET dti-1408 33 168 precursor precursor NOUN dti-1408 33 169 of of ADP dti-1408 33 170 arginine arginine NOUN dti-1408 33 171 vasopressin vasopressin NOUN dti-1408 33 172 ( ( PUNCT dti-1408 33 173 avp avp PROPN dti-1408 33 174 ) ) PUNCT dti-1408 33 175 , , PUNCT dti-1408 33 176 is be AUX dti-1408 33 177 secreted secrete VERB dti-1408 33 178 from from ADP dti-1408 33 179 the the DET dti-1408 33 180 posterior posterior ADJ dti-1408 33 181 pituitary pituitary ADJ dti-1408 33 182 gland gland NOUN dti-1408 33 183 , , PUNCT dti-1408 33 184 and and CCONJ dti-1408 33 185 all all DET dti-1408 33 186 three three NUM dti-1408 33 187 vasopressin vasopressin NOUN dti-1408 33 188 receptors receptor NOUN dti-1408 33 189 have have AUX dti-1408 33 190 been be AUX dti-1408 33 191 found find VERB dti-1408 33 192 in in ADP dti-1408 33 193 the the DET dti-1408 33 194 gastrointestinal gastrointestinal ADJ dti-1408 33 195 tract.15 tract.15 NOUN dti-1408 33 196 the the DET dti-1408 33 197 main main ADJ dti-1408 33 198 roles role NOUN dti-1408 33 199 of of ADP dti-1408 33 200 vasopressin vasopressin NOUN dti-1408 33 201 are be AUX dti-1408 33 202 water water NOUN dti-1408 33 203 reabsorption reabsorption NOUN dti-1408 33 204 through through ADP dti-1408 33 205 v2 v2 NOUN dti-1408 33 206 receptors,16 receptors,16 NOUN dti-1408 33 207 regulation regulation NOUN dti-1408 33 208 of of ADP dti-1408 33 209 vascular vascular ADJ dti-1408 33 210 tone tone NOUN dti-1408 33 211 by by ADP dti-1408 33 212 v1a v1a ADJ dti-1408 33 213 receptor receptor NOUN dti-1408 33 214 activation,17 activation,17 NOUN dti-1408 33 215 and and CCONJ dti-1408 33 216 physiological physiological ADJ dti-1408 33 217 adaptations adaptation NOUN dti-1408 33 218 to to PART dti-1408 33 219 stress stress VERB dti-1408 33 220 through through ADP dti-1408 33 221 adrenocorticotropic adrenocorticotropic NOUN dti-1408 33 222 hormone hormone NOUN dti-1408 33 223 ( ( PUNCT dti-1408 33 224 acth acth NOUN dti-1408 33 225 ) ) PUNCT dti-1408 33 226 release release NOUN dti-1408 33 227 by by ADP dti-1408 33 228 the the DET dti-1408 33 229 posterior posterior ADJ dti-1408 33 230 pituitary pituitary NOUN dti-1408 33 231 involving involve VERB dti-1408 33 232 v1b v1b NOUN dti-1408 33 233 receptors.18 receptors.18 VERB dti-1408 33 234 a a DET dti-1408 33 235 few few ADJ dti-1408 33 236 studies study NOUN dti-1408 33 237 have have AUX dti-1408 33 238 examined examine VERB dti-1408 33 239 the the DET dti-1408 33 240 pharmacological pharmacological NOUN dti-1408 33 241 , , PUNCT dti-1408 33 242 but but CCONJ dti-1408 33 243 not not PART dti-1408 33 244 the the DET dti-1408 33 245 physiological physiological ADJ dti-1408 33 246 , , PUNCT dti-1408 33 247 effect effect NOUN dti-1408 33 248 of of ADP dti-1408 33 249 vasopressin vasopressin NOUN dti-1408 33 250 on on ADP dti-1408 33 251 water water NOUN dti-1408 33 252 and and CCONJ dti-1408 33 253 sodium sodium NOUN dti-1408 33 254 absorption absorption NOUN dti-1408 33 255 and and CCONJ dti-1408 33 256 secretion secretion NOUN dti-1408 33 257 in in ADP dti-1408 33 258 human human ADJ dti-1408 33 259 intestines.19,20 intestines.19,20 NOUN dti-1408 33 260 in in ADP dti-1408 33 261 rodents rodent NOUN dti-1408 33 262 , , PUNCT dti-1408 33 263 vasopressin vasopressin NOUN dti-1408 33 264 has have AUX dti-1408 33 265 been be AUX dti-1408 33 266 reported report VERB dti-1408 33 267 to to PART dti-1408 33 268 exert exert VERB dti-1408 33 269 proinflammatory proinflammatory ADJ dti-1408 33 270 effects effect NOUN dti-1408 33 271 through through ADP dti-1408 33 272 mast mast NOUN dti-1408 33 273 cell cell NOUN dti-1408 33 274 activation activation NOUN dti-1408 33 275 and and CCONJ dti-1408 33 276 enhanced enhance VERB dti-1408 33 277 epithelial epithelial ADJ dti-1408 33 278 permeability permeability NOUN dti-1408 33 279 in in ADP dti-1408 33 280 the the DET dti-1408 33 281 colon.21 colon.21 PROPN dti-1408 33 282 atrial atrial ADJ dti-1408 33 283 natriuretic natriuretic ADJ dti-1408 33 284 peptide peptide NOUN dti-1408 33 285 ( ( PUNCT dti-1408 33 286 anp anp PROPN dti-1408 33 287 ) ) PUNCT dti-1408 33 288 is be AUX dti-1408 33 289 secreted secrete VERB dti-1408 33 290 from from ADP dti-1408 33 291 the the DET dti-1408 33 292 heart heart NOUN dti-1408 33 293 and and CCONJ dti-1408 33 294 contributes contribute VERB dti-1408 33 295 to to ADP dti-1408 33 296 substantial substantial ADJ dti-1408 33 297 fluid fluid ADJ dti-1408 33 298 loss loss NOUN dti-1408 33 299 via via ADP dti-1408 33 300 the the DET dti-1408 33 301 gastrointestinal gastrointestinal ADJ dti-1408 33 302 tract.22 tract.22 NOUN dti-1408 33 303 peptides peptide NOUN dti-1408 33 304 have have VERB dti-1408 33 305 a a DET dti-1408 33 306 short short ADJ dti-1408 33 307 half half ADJ dti-1408 33 308 - - PUNCT dti-1408 33 309 time time NOUN dti-1408 33 310 in in ADP dti-1408 33 311 plasma plasma NOUN dti-1408 33 312 , , PUNCT dti-1408 33 313 so so SCONJ dti-1408 33 314 it it PRON dti-1408 33 315 is be AUX dti-1408 33 316 advantageous advantageous ADJ dti-1408 33 317 to to PART dti-1408 33 318 measure measure VERB dti-1408 33 319 the the DET dti-1408 33 320 highly highly ADV dti-1408 33 321 stable stable ADJ dti-1408 33 322 precursors precursor NOUN dti-1408 33 323 instead instead ADV dti-1408 33 324 journal journal PROPN dti-1408 33 325 name name PROPN dti-1408 33 326 : : PUNCT dti-1408 33 327 drug drug NOUN dti-1408 33 328 target target NOUN dti-1408 33 329 insights insight NOUN dti-1408 33 330 journal journal NOUN dti-1408 33 331 type type NOUN dti-1408 33 332 : : PUNCT dti-1408 33 333 original original ADJ dti-1408 33 334 research research NOUN dti-1408 33 335 year year NOUN dti-1408 33 336 : : PUNCT dti-1408 33 337 2015 2015 NUM dti-1408 33 338 volume volume NOUN dti-1408 33 339 : : PUNCT dti-1408 33 340 9 9 NUM dti-1408 33 341 running run VERB dti-1408 33 342 head head NOUN dti-1408 33 343 verso verso NOUN dti-1408 33 344 : : PUNCT dti-1408 33 345 ohlsson ohlsson NOUN dti-1408 33 346 and and CCONJ dti-1408 33 347 melander melander NOUN dti-1408 33 348 running run VERB dti-1408 33 349 head head NOUN dti-1408 33 350 recto recto ADJ dti-1408 33 351 : : PUNCT dti-1408 33 352 basal basal ADJ dti-1408 33 353 plasma plasma NOUN dti-1408 33 354 levels level NOUN dti-1408 33 355 of of ADP dti-1408 33 356 copeptin copeptin NOUN dti-1408 33 357 in in ADP dti-1408 33 358 ibd ibd PROPN dti-1408 34 1 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1408 34 2 http://www.la-press.com http://www.la-press.com X dti-1408 34 3 http://dx.doi.org/10.4137/dti.s26589 http://dx.doi.org/10.4137/dti.s26589 PROPN dti-1408 34 4 http://creativecommons.org/licenses/by-nc/3.0/ http://creativecommons.org/licenses/by-nc/3.0/ PROPN dti-1408 34 5 http://creativecommons.org/licenses/by-nc/3.0/ http://creativecommons.org/licenses/by-nc/3.0/ PROPN dti-1408 35 1 mailto:bodil.ohlsson@med.lu.se mailto:bodil.ohlsson@med.lu.se PROPN dti-1408 35 2 http://www.la-press.com http://www.la-press.com X dti-1408 36 1 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1408 36 2 ohlsson ohlsson PROPN dti-1408 36 3 and and CCONJ dti-1408 36 4 melander melander VERB dti-1408 36 5 22 22 NUM dti-1408 36 6 drug drug NOUN dti-1408 36 7 target target NOUN dti-1408 36 8 insights insight NOUN dti-1408 36 9 2015:9 2015:9 NUM dti-1408 36 10 of of ADP dti-1408 36 11 peptides peptide NOUN dti-1408 36 12 , , PUNCT dti-1408 36 13 which which PRON dti-1408 36 14 are be AUX dti-1408 36 15 synthesized synthesize VERB dti-1408 36 16 in in ADP dti-1408 36 17 stoichiometric stoichiometric ADJ dti-1408 36 18 amounts amount NOUN dti-1408 36 19 relative relative ADJ dti-1408 36 20 to to ADP dti-1408 36 21 the the DET dti-1408 36 22 mature mature NOUN dti-1408 36 23 peptides.23,24 peptides.23,24 VERB dti-1408 36 24 the the DET dti-1408 36 25 aim aim NOUN dti-1408 36 26 of of ADP dti-1408 36 27 the the DET dti-1408 36 28 present present ADJ dti-1408 36 29 pilot pilot NOUN dti-1408 36 30 study study NOUN dti-1408 36 31 was be AUX dti-1408 36 32 to to PART dti-1408 36 33 analyze analyze VERB dti-1408 36 34 the the DET dti-1408 36 35 basal basal ADJ dti-1408 36 36 plasma plasma NOUN dti-1408 36 37 levels level NOUN dti-1408 36 38 of of ADP dti-1408 36 39 a a DET dti-1408 36 40 variety variety NOUN dti-1408 36 41 of of ADP dti-1408 36 42 peptide peptide ADJ dti-1408 36 43 precursors precursor NOUN dti-1408 36 44 involved involve VERB dti-1408 36 45 in in ADP dti-1408 36 46 the the DET dti-1408 36 47 physiology physiology NOUN dti-1408 36 48 of of ADP dti-1408 36 49 the the DET dti-1408 36 50 gastrointestinal gastrointestinal ADJ dti-1408 36 51 tract tract NOUN dti-1408 36 52 , , PUNCT dti-1408 36 53 ie ie X dti-1408 36 54 , , PUNCT dti-1408 36 55 copeptin copeptin NOUN dti-1408 36 56 , , PUNCT dti-1408 36 57 midregional midregional ADJ dti-1408 36 58 fragment fragment NOUN dti-1408 36 59 of of ADP dti-1408 36 60 pro pro ADJ dti-1408 36 61 - - ADJ dti-1408 36 62 adrenomedullin adrenomedullin NOUN dti-1408 36 63 ( ( PUNCT dti-1408 36 64 mr mr PROPN dti-1408 36 65 - - PUNCT dti-1408 36 66 proadm proadm NOUN dti-1408 36 67 ) ) PUNCT dti-1408 36 68 , , PUNCT dti-1408 36 69 midregional midregional ADJ dti-1408 36 70 fragment fragment NOUN dti-1408 36 71 of of ADP dti-1408 36 72 pro pro ADJ dti-1408 36 73 - - ADJ dti-1408 36 74 atrial atrial ADJ dti-1408 36 75 natriuretic natriuretic ADJ dti-1408 36 76 peptide peptide NOUN dti-1408 36 77 ( ( PUNCT dti-1408 36 78 mr mr PROPN dti-1408 36 79 - - PUNCT dti-1408 36 80 proanp proanp NOUN dti-1408 36 81 ) ) PUNCT dti-1408 36 82 , , PUNCT dti-1408 36 83 midregional midregional ADJ dti-1408 36 84 fragment fragment NOUN dti-1408 36 85 of of ADP dti-1408 36 86 proenkephalin proenkephalin PROPN dti-1408 36 87 a a PROPN dti-1408 36 88 ( ( PUNCT dti-1408 36 89 mr mr PROPN dti-1408 36 90 - - PUNCT dti-1408 36 91 penk penk PROPN dti-1408 36 92 a a NOUN dti-1408 36 93 ) ) PUNCT dti-1408 36 94 , , PUNCT dti-1408 36 95 n n CCONJ dti-1408 36 96 - - PUNCT dti-1408 36 97 terminal terminal ADJ dti-1408 36 98 protachykinin protachykinin NOUN dti-1408 36 99 a a DET dti-1408 36 100 ( ( PUNCT dti-1408 36 101 nt not PART dti-1408 36 102 - - PUNCT dti-1408 36 103 pta pta NOUN dti-1408 36 104 ) ) PUNCT dti-1408 36 105 , , PUNCT dti-1408 36 106 and and CCONJ dti-1408 36 107 proneurotensin proneurotensin VERB dti-1408 36 108 , , PUNCT dti-1408 36 109 in in ADP dti-1408 36 110 two two NUM dti-1408 36 111 well well ADV dti-1408 36 112 - - PUNCT dti-1408 36 113 defined define VERB dti-1408 36 114 populations population NOUN dti-1408 36 115 of of ADP dti-1408 36 116 patients patient NOUN dti-1408 36 117 with with ADP dti-1408 36 118 ibd ibd PROPN dti-1408 36 119 , , PUNCT dti-1408 36 120 as as SCONJ dti-1408 36 121 these these DET dti-1408 36 122 precursors precursor NOUN dti-1408 36 123 have have AUX dti-1408 36 124 been be AUX dti-1408 36 125 discussed discuss VERB dti-1408 36 126 in in ADP dti-1408 36 127 the the DET dti-1408 36 128 development development NOUN dti-1408 36 129 and and CCONJ dti-1408 36 130 activity activity NOUN dti-1408 36 131 of of ADP dti-1408 36 132 gastrointestinal gastrointestinal ADJ dti-1408 36 133 diseases disease NOUN dti-1408 36 134 . . PUNCT dti-1408 37 1 material material NOUN dti-1408 37 2 and and CCONJ dti-1408 37 3 methods method NOUN dti-1408 37 4 the the DET dti-1408 37 5 research research NOUN dti-1408 37 6 protocol protocol NOUN dti-1408 37 7 was be AUX dti-1408 37 8 in in ADP dti-1408 37 9 accordance accordance NOUN dti-1408 37 10 with with ADP dti-1408 37 11 the the DET dti-1408 37 12 declaration declaration NOUN dti-1408 37 13 of of ADP dti-1408 37 14 helsinki helsinki PROPN dti-1408 37 15 , , PUNCT dti-1408 37 16 and and CCONJ dti-1408 37 17 the the DET dti-1408 37 18 study study NOUN dti-1408 37 19 was be AUX dti-1408 37 20 approved approve VERB dti-1408 37 21 by by ADP dti-1408 37 22 the the DET dti-1408 37 23 ethics ethic NOUN dti-1408 37 24 committee committee PROPN dti-1408 37 25 of of ADP dti-1408 37 26 lund lund PROPN dti-1408 37 27 university university PROPN dti-1408 37 28 ( ( PUNCT dti-1408 37 29 2013/609 2013/609 NUM dti-1408 37 30 ) ) PUNCT dti-1408 37 31 . . PUNCT dti-1408 38 1 study study NOUN dti-1408 38 2 population population NOUN dti-1408 38 3 . . PUNCT dti-1408 39 1 the the DET dti-1408 39 2 malmö malmö PROPN dti-1408 39 3 preventive preventive ADJ dti-1408 39 4 medicine medicine NOUN dti-1408 39 5 ( ( PUNCT dti-1408 39 6 mpm mpm NOUN dti-1408 39 7 ) ) PUNCT dti-1408 39 8 study study NOUN dti-1408 39 9 is be AUX dti-1408 39 10 a a DET dti-1408 39 11 population population NOUN dti-1408 39 12 - - PUNCT dti-1408 39 13 based base VERB dti-1408 39 14 , , PUNCT dti-1408 39 15 prospective prospective ADJ dti-1408 39 16 , , PUNCT dti-1408 39 17 epidemiologic epidemiologic ADJ dti-1408 39 18 cohort cohort NOUN dti-1408 39 19 of of ADP dti-1408 39 20     SPACE dti-1408 39 21 22,444 22,444 NUM dti-1408 39 22 men man NOUN dti-1408 39 23 ( ( PUNCT dti-1408 39 24 born bear VERB dti-1408 39 25 between between ADP dti-1408 39 26 1921 1921 NUM dti-1408 39 27 and and CCONJ dti-1408 39 28 1949 1949 NUM dti-1408 39 29 ) ) PUNCT dti-1408 39 30 and and CCONJ dti-1408 39 31 10,902 10,902 NUM dti-1408 39 32 women woman NOUN dti-1408 39 33 ( ( PUNCT dti-1408 39 34 born bear VERB dti-1408 39 35 between between ADP dti-1408 39 36 1926 1926 NUM dti-1408 39 37 and and CCONJ dti-1408 39 38 1949 1949 NUM dti-1408 39 39 ) ) PUNCT dti-1408 39 40 from from ADP dti-1408 39 41 malmö malmö PROPN dti-1408 39 42 , , PUNCT dti-1408 39 43 sweden sweden PROPN dti-1408 39 44 , , PUNCT dti-1408 39 45 who who PRON dti-1408 39 46 underwent undergo VERB dti-1408 39 47 baseline baseline NOUN dti-1408 39 48 examinations examination NOUN dti-1408 39 49 between between ADP dti-1408 39 50 1974 1974 NUM dti-1408 39 51 and and CCONJ dti-1408 39 52 1992.25 1992.25 NUM dti-1408 39 53 from from ADP dti-1408 39 54 this this DET dti-1408 39 55 cohort cohort NOUN dti-1408 39 56 , , PUNCT dti-1408 39 57 18,240 18,240 NUM dti-1408 39 58 were be AUX dti-1408 39 59 re re VERB dti-1408 39 60 - - VERB dti-1408 39 61 examined examine VERB dti-1408 39 62 from from ADP dti-1408 39 63 2002 2002 NUM dti-1408 39 64 to to ADP dti-1408 39 65 2006 2006 NUM dti-1408 39 66 , , PUNCT dti-1408 39 67 and and CCONJ dti-1408 39 68 new new ADJ dti-1408 39 69 blood blood NOUN dti-1408 39 70 samples sample NOUN dti-1408 39 71 were be AUX dti-1408 39 72 collected collect VERB dti-1408 39 73 . . PUNCT dti-1408 40 1 out out ADP dti-1408 40 2 of of ADP dti-1408 40 3 these these PRON dti-1408 40 4 , , PUNCT dti-1408 40 5 5,415 5,415 NUM dti-1408 40 6 were be AUX dti-1408 40 7 randomly randomly ADV dti-1408 40 8 chosen choose VERB dti-1408 40 9 for for ADP dti-1408 40 10 precursor precursor NOUN dti-1408 40 11 analyses analysis NOUN dti-1408 40 12 . . PUNCT dti-1408 41 1 the the DET dti-1408 41 2 malmö malmö PROPN dti-1408 41 3 diet diet PROPN dti-1408 41 4 and and CCONJ dti-1408 41 5 cancer cancer NOUN dti-1408 41 6 study study NOUN dti-1408 41 7 ( ( PUNCT dti-1408 41 8 mdcs mdcs PROPN dti-1408 41 9 ) ) PUNCT dti-1408 41 10 is be AUX dti-1408 41 11 a a DET dti-1408 41 12 population population NOUN dti-1408 41 13 - - PUNCT dti-1408 41 14 based base VERB dti-1408 41 15 , , PUNCT dti-1408 41 16 prospective prospective ADJ dti-1408 41 17 , , PUNCT dti-1408 41 18 epidemiologic epidemiologic ADJ dti-1408 41 19 cohort cohort NOUN dti-1408 41 20 of of ADP dti-1408 41 21 28,449 28,449 NUM dti-1408 41 22 men man NOUN dti-1408 41 23 ( ( PUNCT dti-1408 41 24 born bear VERB dti-1408 41 25 between between ADP dti-1408 41 26 1923 1923 NUM dti-1408 41 27 and and CCONJ dti-1408 41 28 1945 1945 NUM dti-1408 41 29 ) ) PUNCT dti-1408 41 30 and and CCONJ dti-1408 41 31 women woman NOUN dti-1408 41 32 ( ( PUNCT dti-1408 41 33 born bear VERB dti-1408 41 34 between between ADP dti-1408 41 35 1923 1923 NUM dti-1408 41 36 and and CCONJ dti-1408 41 37 1950 1950 NUM dti-1408 41 38 ) ) PUNCT dti-1408 41 39 from from ADP dti-1408 41 40 malmö malmö PROPN dti-1408 41 41 , , PUNCT dti-1408 41 42 sweden sweden PROPN dti-1408 41 43 , , PUNCT dti-1408 41 44 who who PRON dti-1408 41 45 underwent undergo VERB dti-1408 41 46 baseline baseline NOUN dti-1408 41 47 examinations examination NOUN dti-1408 41 48 between between ADP dti-1408 41 49 1991 1991 NUM dti-1408 41 50 and and CCONJ dti-1408 41 51 1996 1996 NUM dti-1408 41 52 . . PUNCT dti-1408 42 1 from from ADP dti-1408 42 2 this this DET dti-1408 42 3 cohort cohort NOUN dti-1408 42 4 , , PUNCT dti-1408 42 5 6,103 6,103 NUM dti-1408 42 6 individuals individual NOUN dti-1408 42 7 were be AUX dti-1408 42 8 randomly randomly ADV dti-1408 42 9 selected select VERB dti-1408 42 10 to to PART dti-1408 42 11 participate participate VERB dti-1408 42 12 in in ADP dti-1408 42 13 the the DET dti-1408 42 14 mdcs mdcs ADJ dti-1408 42 15 cardiovascular cardiovascular ADJ dti-1408 42 16 cohort cohort NOUN dti-1408 42 17 ( ( PUNCT dti-1408 42 18 mdc mdc NOUN dti-1408 42 19 - - PUNCT dti-1408 42 20 cc cc NOUN dti-1408 42 21 ) ) PUNCT dti-1408 42 22 , , PUNCT dti-1408 42 23 which which PRON dti-1408 42 24 was be AUX dti-1408 42 25 designed design VERB dti-1408 42 26 to to PART dti-1408 42 27 investigate investigate VERB dti-1408 42 28 the the DET dti-1408 42 29 epidemiology epidemiology NOUN dti-1408 42 30 of of ADP dti-1408 42 31 carotid carotid NOUN dti-1408 42 32 artery artery NOUN dti-1408 42 33 disease disease NOUN dti-1408 42 34 between between ADP dti-1408 42 35 1991 1991 NUM dti-1408 42 36 and and CCONJ dti-1408 42 37 1994.26 1994.26 NUM dti-1408 42 38 the the DET dti-1408 42 39 baseline baseline NOUN dti-1408 42 40 examination examination NOUN dti-1408 42 41 procedure procedure NOUN dti-1408 42 42 has have AUX dti-1408 42 43 been be AUX dti-1408 42 44 described describe VERB dti-1408 42 45 in in ADP dti-1408 42 46 detail detail NOUN dti-1408 42 47 previously.27 previously.27 PROPN dti-1408 42 48 briefly briefly NOUN dti-1408 42 49 , , PUNCT dti-1408 42 50 the the DET dti-1408 42 51 mpm mpm NOUN dti-1408 42 52 and and CCONJ dti-1408 42 53 mdc mdc NOUN dti-1408 42 54 - - PUNCT dti-1408 42 55 cc cc NOUN dti-1408 42 56 baseline baseline NOUN dti-1408 42 57 examinations examination NOUN dti-1408 42 58 included include VERB dti-1408 42 59 a a DET dti-1408 42 60 dietary dietary ADJ dti-1408 42 61 assessment assessment NOUN dti-1408 42 62 ; ; PUNCT dti-1408 42 63 a a DET dti-1408 42 64 self self NOUN dti-1408 42 65 - - PUNCT dti-1408 42 66 administered administer VERB dti-1408 42 67 questionnaire questionnaire NOUN dti-1408 42 68 about about ADP dti-1408 42 69 marital marital ADJ dti-1408 42 70 status status NOUN dti-1408 42 71 , , PUNCT dti-1408 42 72 education education NOUN dti-1408 42 73 , , PUNCT dti-1408 42 74 employment employment NOUN dti-1408 42 75 , , PUNCT dti-1408 42 76 smoking smoking NOUN dti-1408 42 77 habits habit NOUN dti-1408 42 78 , , PUNCT dti-1408 42 79 wine wine NOUN dti-1408 42 80 consumption consumption NOUN dti-1408 42 81 , , PUNCT dti-1408 42 82 physical physical ADJ dti-1408 42 83 activity activity NOUN dti-1408 42 84 , , PUNCT dti-1408 42 85 medical medical ADJ dti-1408 42 86 conditions condition NOUN dti-1408 42 87 and and CCONJ dti-1408 42 88 medication medication NOUN dti-1408 42 89 ; ; PUNCT dti-1408 42 90 anthropometric anthropometric ADJ dti-1408 42 91 measurements measurement NOUN dti-1408 42 92 ; ; PUNCT dti-1408 42 93 and and CCONJ dti-1408 42 94 collection collection NOUN dti-1408 42 95 of of ADP dti-1408 42 96 blood blood NOUN dti-1408 42 97 samples sample NOUN dti-1408 42 98 . . PUNCT dti-1408 43 1 at at ADP dti-1408 43 2 baseline baseline NOUN dti-1408 43 3 , , PUNCT dti-1408 43 4 no no DET dti-1408 43 5 questions question NOUN dti-1408 43 6 concerning concern VERB dti-1408 43 7 bowel bowel NOUN dti-1408 43 8 diseases disease NOUN dti-1408 43 9 were be AUX dti-1408 43 10 asked ask VERB dti-1408 43 11 . . PUNCT dti-1408 44 1 thus thus ADV dti-1408 44 2 , , PUNCT dti-1408 44 3 we we PRON dti-1408 44 4 used use VERB dti-1408 44 5 local local ADJ dti-1408 44 6 registers register NOUN dti-1408 44 7 to to PART dti-1408 44 8 retrieve retrieve VERB dti-1408 44 9 prevalent prevalent ADJ dti-1408 44 10 cases case NOUN dti-1408 44 11 of of ADP dti-1408 44 12 ibd ibd NOUN dti-1408 44 13 according accord VERB dti-1408 44 14 to to ADP dti-1408 44 15 the the DET dti-1408 44 16 international international ADJ dti-1408 44 17 classification classification NOUN dti-1408 44 18 of of ADP dti-1408 44 19 diseases disease NOUN dti-1408 44 20 ( ( PUNCT dti-1408 44 21 icd icd NOUN dti-1408 44 22 ) ) PUNCT dti-1408 44 23 version version NOUN dti-1408 44 24 8 8 NUM dti-1408 44 25 , , PUNCT dti-1408 44 26 9 9 NUM dti-1408 44 27 , , PUNCT dti-1408 44 28 and and CCONJ dti-1408 44 29 10 10 NUM dti-1408 44 30 . . PUNCT dti-1408 45 1 we we PRON dti-1408 45 2 initially initially ADV dti-1408 45 3 identified identify VERB dti-1408 45 4 35 35 NUM dti-1408 45 5     SPACE dti-1408 45 6 patients patient NOUN dti-1408 45 7 with with ADP dti-1408 45 8 ibd ibd PROPN dti-1408 45 9 in in ADP dti-1408 45 10 the the DET dti-1408 45 11 mpm mpm NOUN dti-1408 45 12 re re NOUN dti-1408 45 13 - - NOUN dti-1408 45 14 examination examination ADJ dti-1408 45 15 cohort cohort NOUN dti-1408 45 16 with with ADP dti-1408 45 17 available available ADJ dti-1408 45 18 precursors precursor NOUN dti-1408 45 19 analyses analysis NOUN dti-1408 45 20 , , PUNCT dti-1408 45 21 and and CCONJ dti-1408 45 22 70 70 NUM dti-1408 45 23 patients patient NOUN dti-1408 45 24 with with ADP dti-1408 45 25 ibd ibd PROPN dti-1408 45 26 in in ADP dti-1408 45 27 the the DET dti-1408 45 28 mdc mdc NOUN dti-1408 45 29 - - PUNCT dti-1408 45 30 cc cc NOUN dti-1408 45 31 cohort cohort NOUN dti-1408 45 32 . . PUNCT dti-1408 46 1 the the DET dti-1408 46 2 diagnoses diagnosis NOUN dti-1408 46 3 were be AUX dti-1408 46 4 validated validate VERB dti-1408 46 5 by by ADP dti-1408 46 6 scrutinizing scrutinize VERB dti-1408 46 7 all all DET dti-1408 46 8 the the DET dti-1408 46 9 medical medical ADJ dti-1408 46 10 records record NOUN dti-1408 46 11 , , PUNCT dti-1408 46 12 and and CCONJ dti-1408 46 13 all all DET dti-1408 46 14 patients patient NOUN dti-1408 46 15 with with ADP dti-1408 46 16 a a DET dti-1408 46 17 clinical clinical ADJ dti-1408 46 18 diagnosis diagnosis NOUN dti-1408 46 19 made make VERB dti-1408 46 20 after after ADP dti-1408 46 21 careful careful ADJ dti-1408 46 22 clinical clinical ADJ dti-1408 46 23 examination examination NOUN dti-1408 46 24 including include VERB dti-1408 46 25 endoscopy endoscopy NOUN dti-1408 46 26 and and CCONJ dti-1408 46 27 histopathological histopathological ADJ dti-1408 46 28 examination examination NOUN dti-1408 46 29 were be AUX dti-1408 46 30 included include VERB dti-1408 46 31 in in ADP dti-1408 46 32 the the DET dti-1408 46 33 study study NOUN dti-1408 46 34 . . PUNCT dti-1408 47 1 from from ADP dti-1408 47 2 the the DET dti-1408 47 3 medical medical ADJ dti-1408 47 4 records record NOUN dti-1408 47 5 , , PUNCT dti-1408 47 6 the the DET dti-1408 47 7 activity activity NOUN dti-1408 47 8 and and CCONJ dti-1408 47 9 extent extent NOUN dti-1408 47 10 of of ADP dti-1408 47 11 disease disease NOUN dti-1408 47 12 , , PUNCT dti-1408 47 13 concomitant concomitant ADJ dti-1408 47 14 diseases disease NOUN dti-1408 47 15 , , PUNCT dti-1408 47 16 drug drug NOUN dti-1408 47 17 treatment treatment NOUN dti-1408 47 18 , , PUNCT dti-1408 47 19 and and CCONJ dti-1408 47 20 bowel bowel NOUN dti-1408 47 21 resections resection NOUN dti-1408 47 22 were be AUX dti-1408 47 23 recognized recognize VERB dti-1408 47 24 . . PUNCT dti-1408 48 1 disease disease NOUN dti-1408 48 2 involvement involvement NOUN dti-1408 48 3 in in ADP dti-1408 48 4 more more ADJ dti-1408 48 5 than than ADP dti-1408 48 6 one one NUM dti-1408 48 7 gastrointestinal gastrointestinal ADJ dti-1408 48 8 segment segment NOUN dti-1408 48 9 was be AUX dti-1408 48 10 defined define VERB dti-1408 48 11 as as ADP dti-1408 48 12 extensive extensive ADJ dti-1408 48 13 disease disease NOUN dti-1408 48 14 . . PUNCT dti-1408 49 1 six six NUM dti-1408 49 2 patients patient NOUN dti-1408 49 3 in in ADP dti-1408 49 4 the the DET dti-1408 49 5 mpm mpm NOUN dti-1408 49 6 cohort cohort NOUN dti-1408 49 7 and and CCONJ dti-1408 49 8 nine nine NUM dti-1408 49 9 patients patient NOUN dti-1408 49 10 in in ADP dti-1408 49 11 the the DET dti-1408 49 12 mdccc mdccc PROPN dti-1408 49 13 were be AUX dti-1408 49 14 excluded exclude VERB dti-1408 49 15 due due ADP dti-1408 49 16 to to ADP dti-1408 49 17 wrong wrong ADJ dti-1408 49 18 diagnosis diagnosis NOUN dti-1408 49 19 , , PUNCT dti-1408 49 20 the the DET dti-1408 49 21 coexistence coexistence NOUN dti-1408 49 22 of of ADP dti-1408 49 23 cardiovascular cardiovascular ADJ dti-1408 49 24 disease disease NOUN dti-1408 49 25 , , PUNCT dti-1408 49 26 diabetes diabetes NOUN dti-1408 49 27 mellitus mellitus NOUN dti-1408 49 28 , , PUNCT dti-1408 49 29 or or CCONJ dti-1408 49 30 malignancy malignancy NOUN dti-1408 49 31 , , PUNCT dti-1408 49 32 or or CCONJ dti-1408 49 33 the the DET dti-1408 49 34 medical medical ADJ dti-1408 49 35 records record NOUN dti-1408 49 36 not not PART dti-1408 49 37 being be AUX dti-1408 49 38 found find VERB dti-1408 49 39 in in ADP dti-1408 49 40 the the DET dti-1408 49 41 archive archive NOUN dti-1408 49 42 and and CCONJ dti-1408 49 43 hence hence ADV dti-1408 49 44 validation validation NOUN dti-1408 49 45 according accord VERB dti-1408 49 46 to to ADP dti-1408 49 47 prevalent prevalent ADJ dti-1408 49 48 or or CCONJ dti-1408 49 49 incident incident NOUN dti-1408 49 50 ibd ibd NOUN dti-1408 49 51 , , PUNCT dti-1408 49 52 disease disease NOUN dti-1408 49 53 activity activity NOUN dti-1408 49 54 , , PUNCT dti-1408 49 55 and and CCONJ dti-1408 49 56 concomitant concomitant ADJ dti-1408 49 57 diseases disease NOUN dti-1408 49 58 could could AUX dti-1408 49 59 not not PART dti-1408 49 60 be be AUX dti-1408 49 61 performed perform VERB dti-1408 49 62 . . PUNCT dti-1408 50 1 thus thus ADV dti-1408 50 2 , , PUNCT dti-1408 50 3 after after ADP dti-1408 50 4 validation validation NOUN dti-1408 50 5 of of ADP dti-1408 50 6 the the DET dti-1408 50 7 information information NOUN dti-1408 50 8 from from ADP dti-1408 50 9 the the DET dti-1408 50 10 register register NOUN dti-1408 50 11 using use VERB dti-1408 50 12 the the DET dti-1408 50 13 medical medical ADJ dti-1408 50 14 records record NOUN dti-1408 50 15 , , PUNCT dti-1408 50 16 22 22 NUM dti-1408 50 17 prevalent prevalent ADJ dti-1408 50 18 and and CCONJ dti-1408 50 19 7 7 NUM dti-1408 50 20 incident incident NOUN dti-1408 50 21 cases case NOUN dti-1408 50 22 of of ADP dti-1408 50 23 ibd ibd NOUN dti-1408 50 24 remained remain VERB dti-1408 50 25 in in ADP dti-1408 50 26 the the DET dti-1408 50 27 mpm mpm NOUN dti-1408 50 28 cohort cohort NOUN dti-1408 50 29 and and CCONJ dti-1408 50 30 40 40 NUM dti-1408 50 31 prevalent prevalent ADJ dti-1408 50 32 and and CCONJ dti-1408 50 33 21 21 NUM dti-1408 50 34 incident incident NOUN dti-1408 50 35 cases case NOUN dti-1408 50 36 in in ADP dti-1408 50 37 the the DET dti-1408 50 38 mdc mdc NOUN dti-1408 50 39 - - PUNCT dti-1408 50 40 cc cc NOUN dti-1408 50 41 , , PUNCT dti-1408 50 42 at at ADP dti-1408 50 43 the the DET dti-1408 50 44 time time NOUN dti-1408 50 45 point point NOUN dti-1408 50 46 when when SCONJ dti-1408 50 47 plasma plasma NOUN dti-1408 50 48 samples sample NOUN dti-1408 50 49 were be AUX dti-1408 50 50 collected collect VERB dti-1408 50 51 . . PUNCT dti-1408 51 1 analyses analysis NOUN dti-1408 51 2 . . PUNCT dti-1408 52 1 at at ADP dti-1408 52 2 the the DET dti-1408 52 3 mpm mpm NOUN dti-1408 52 4 reexamination reexamination NOUN dti-1408 52 5 and and CCONJ dti-1408 52 6 at at ADP dti-1408 52 7 the the DET dti-1408 52 8 mdccc mdccc PROPN dti-1408 52 9 baseline baseline PROPN dti-1408 52 10 examination examination NOUN dti-1408 52 11 , , PUNCT dti-1408 52 12 blood blood NOUN dti-1408 52 13 was be AUX dti-1408 52 14 collected collect VERB dti-1408 52 15 in in ADP dti-1408 52 16 the the DET dti-1408 52 17 morning morning NOUN dti-1408 52 18 after after ADP dti-1408 52 19 12 12 NUM dti-1408 52 20     SPACE dti-1408 52 21 hours hour NOUN dti-1408 52 22 of of ADP dti-1408 52 23 fasting fasting NOUN dti-1408 52 24 , , PUNCT dti-1408 52 25 and and CCONJ dti-1408 52 26 plasma plasma NOUN dti-1408 52 27 was be AUX dti-1408 52 28 separated separate VERB dti-1408 52 29 and and CCONJ dti-1408 52 30 immediately immediately ADV dti-1408 52 31 frozen freeze VERB dti-1408 52 32 at at ADP dti-1408 52 33 −80 −80 PROPN dti-1408 52 34 ° ° ADP dti-1408 52 35 c c NOUN dti-1408 52 36 . . PUNCT dti-1408 53 1 in in ADP dti-1408 53 2 the the DET dti-1408 53 3 mdc mdc PROPN dti-1408 53 4 - - PUNCT dti-1408 53 5 cc cc NOUN dti-1408 53 6 , , PUNCT dti-1408 53 7 plasma plasma NOUN dti-1408 53 8 samples sample NOUN dti-1408 53 9 were be AUX dti-1408 53 10 available available ADJ dti-1408 53 11 for for ADP dti-1408 53 12 analyses analysis NOUN dti-1408 53 13 of of ADP dti-1408 53 14 mr mr PROPN dti-1408 53 15 - - PUNCT dti-1408 53 16 penk penk PROPN dti-1408 53 17 , , PUNCT dti-1408 53 18 nt not PART dti-1408 53 19 - - PUNCT dti-1408 53 20 pta pta NOUN dti-1408 53 21 , , PUNCT dti-1408 53 22 and and CCONJ dti-1408 53 23 proneurotensin proneurotensin VERB dti-1408 53 24 in in ADP dti-1408 53 25 4,632 4,632 NUM dti-1408 53 26 participants participant NOUN dti-1408 53 27 , , PUNCT dti-1408 53 28 and and CCONJ dti-1408 53 29 for for ADP dti-1408 53 30 analyses analysis NOUN dti-1408 53 31 of of ADP dti-1408 53 32 copeptin copeptin NOUN dti-1408 53 33 , , PUNCT dti-1408 53 34 mr mr PROPN dti-1408 53 35 - - PUNCT dti-1408 53 36 proadm proadm PROPN dti-1408 53 37 , , PUNCT dti-1408 53 38 and and CCONJ dti-1408 53 39 mr mr PROPN dti-1408 53 40 - - PUNCT dti-1408 53 41 proanp proanp PROPN dti-1408 53 42 in in ADP dti-1408 53 43 4,742 4,742 NUM dti-1408 53 44 participants participant NOUN dti-1408 53 45 . . PUNCT dti-1408 54 1 the the DET dti-1408 54 2 excluded exclude VERB dti-1408 54 3 participants participant NOUN dti-1408 54 4 ( ( PUNCT dti-1408 54 5 due due ADP dti-1408 54 6 to to ADP dti-1408 54 7 lack lack NOUN dti-1408 54 8 of of ADP dti-1408 54 9 plasma plasma NOUN dti-1408 54 10 samples sample NOUN dti-1408 54 11 ) ) PUNCT dti-1408 54 12 were be AUX dti-1408 54 13 slightly slightly ADV dti-1408 54 14 younger young ADJ dti-1408 54 15 , , PUNCT dti-1408 54 16 but but CCONJ dti-1408 54 17 did do AUX dti-1408 54 18 not not PART dti-1408 54 19 otherwise otherwise ADV dti-1408 54 20 differ differ VERB dti-1408 54 21 in in ADP dti-1408 54 22 terms term NOUN dti-1408 54 23 of of ADP dti-1408 54 24 sex sex NOUN dti-1408 54 25 , , PUNCT dti-1408 54 26 smoking smoking NOUN dti-1408 54 27 habits habit NOUN dti-1408 54 28 , , PUNCT dti-1408 54 29 diabetes diabetes NOUN dti-1408 54 30 , , PUNCT dti-1408 54 31 hypertension hypertension NOUN dti-1408 54 32 status status NOUN dti-1408 54 33 , , PUNCT dti-1408 54 34 body body NOUN dti-1408 54 35 mass mass NOUN dti-1408 54 36 index index NOUN dti-1408 54 37 ( ( PUNCT dti-1408 54 38 bmi bmi PROPN dti-1408 54 39 ) ) PUNCT dti-1408 54 40 , , PUNCT dti-1408 54 41 or or CCONJ dti-1408 54 42 plasma plasma PROPN dti-1408 54 43 lipids.27,28 lipids.27,28 NOUN dti-1408 54 44 copeptin copeptin PROPN dti-1408 54 45 , , PUNCT dti-1408 54 46 the the DET dti-1408 54 47 stable stable ADJ dti-1408 54 48 precursor precursor NOUN dti-1408 54 49 peptide peptide NOUN dti-1408 54 50 of of ADP dti-1408 54 51 avp avp PROPN dti-1408 54 52 , , PUNCT dti-1408 54 53 was be AUX dti-1408 54 54 measured measure VERB dti-1408 54 55 by by ADP dti-1408 54 56 a a DET dti-1408 54 57 murine murine ADJ dti-1408 54 58 monoclonal monoclonal NOUN dti-1408 54 59 antibody antibody NOUN dti-1408 54 60 directed direct VERB dti-1408 54 61 to to ADP dti-1408 54 62 amino amino ADJ dti-1408 54 63 acids acid NOUN dti-1408 54 64 137–144 137–144 NUM dti-1408 54 65 of of ADP dti-1408 54 66 proavp proavp VERB dti-1408 54 67 using use VERB dti-1408 54 68 a a DET dti-1408 54 69 commercially commercially ADV dti-1408 54 70 available available ADJ dti-1408 54 71 assay assay NOUN dti-1408 54 72 in in ADP dti-1408 54 73 the the DET dti-1408 54 74 chemiluminescence chemiluminescence NOUN dti-1408 54 75 / / SYM dti-1408 54 76 coated coat VERB dti-1408 54 77 tube tube NOUN dti-1408 54 78 format format NOUN dti-1408 54 79 ( ( PUNCT dti-1408 54 80 lumitest lumitest NOUN dti-1408 54 81 ct ct ADV dti-1408 54 82 - - PUNCT dti-1408 54 83 proavp proavp VERB dti-1408 54 84 , , PUNCT dti-1408 54 85 brahms brahms NOUN dti-1408 54 86 gmbh gmbh PROPN dti-1408 54 87 ) ) PUNCT dti-1408 54 88 as as SCONJ dti-1408 54 89 described describe VERB dti-1408 54 90 previously.29 previously.29 NOUN dti-1408 54 91 mr mr PROPN dti-1408 54 92 - - PUNCT dti-1408 54 93 proadm proadm PROPN dti-1408 54 94 and and CCONJ dti-1408 54 95 mr mr PROPN dti-1408 54 96 - - PUNCT dti-1408 54 97 proanp proanp PROPN dti-1408 54 98 were be AUX dti-1408 54 99 analyzed analyze VERB dti-1408 54 100 using use VERB dti-1408 54 101 sandwich sandwich NOUN dti-1408 54 102 immunoluminometric immunoluminometric ADJ dti-1408 54 103 assays assay NOUN dti-1408 54 104 targeted target VERB dti-1408 54 105 against against ADP dti-1408 54 106 amino amino ADJ dti-1408 54 107 acids acid NOUN dti-1408 54 108 in in ADP dti-1408 54 109 the the DET dti-1408 54 110 mid mid NOUN dti-1408 54 111 - - NOUN dti-1408 54 112 regions region NOUN dti-1408 54 113 of of ADP dti-1408 54 114 the the DET dti-1408 54 115 respective respective ADJ dti-1408 54 116 peptide peptide NOUN dti-1408 54 117 ( ( PUNCT dti-1408 54 118 brahms brahms PROPN dti-1408 54 119 sevadil sevadil PROPN dti-1408 54 120 lia lia PROPN dti-1408 54 121 ® ® PROPN dti-1408 54 122 and and CCONJ dti-1408 54 123 brahms brahms PROPN dti-1408 54 124 seristra seristra PROPN dti-1408 54 125 ® ® PROPN dti-1408 54 126 , , PUNCT dti-1408 54 127 respectively respectively ADV dti-1408 54 128 , , PUNCT dti-1408 54 129 brahms brahms NOUN dti-1408 54 130 gmbh).30,31 gmbh).30,31 PROPN dti-1408 54 131 briefly briefly ADV dti-1408 54 132 , , PUNCT dti-1408 54 133 two two NUM dti-1408 54 134 polyclonal polyclonal ADJ dti-1408 54 135 antibodies antibody NOUN dti-1408 54 136 targeted target VERB dti-1408 54 137 to to ADP dti-1408 54 138 amino amino ADJ dti-1408 54 139 acids acid NOUN dti-1408 54 140 45–92 45–92 PROPN dti-1408 54 141 of of ADP dti-1408 54 142 proadm proadm PROPN dti-1408 54 143 was be AUX dti-1408 54 144 used use VERB dti-1408 54 145 for for ADP dti-1408 54 146 the the DET dti-1408 54 147 measurement measurement NOUN dti-1408 54 148 of of ADP dti-1408 54 149 mr mr PROPN dti-1408 54 150 - - PUNCT dti-1408 54 151 proadm,30 proadm,30 PROPN dti-1408 54 152 and and CCONJ dti-1408 54 153 polyclonal polyclonal ADJ dti-1408 54 154 sheep sheep NOUN dti-1408 54 155 antibodies antibodie VERB dti-1408 54 156 specific specific ADJ dti-1408 54 157 for for ADP dti-1408 54 158 amino amino ADJ dti-1408 54 159 acids acid NOUN dti-1408 54 160 73–90 73–90 NUM dti-1408 54 161 were be AUX dti-1408 54 162 used use VERB dti-1408 54 163 for for ADP dti-1408 54 164 the the DET dti-1408 54 165 measurement measurement NOUN dti-1408 54 166 of of ADP dti-1408 54 167 mr mr PROPN dti-1408 54 168 - - PUNCT dti-1408 54 169 proanp.31 proanp.31 PROPN dti-1408 54 170 mr mr PROPN dti-1408 54 171 - - PUNCT dti-1408 54 172 penk penk NOUN dti-1408 54 173 a a PRON dti-1408 54 174 is be AUX dti-1408 54 175 the the DET dti-1408 54 176 stable stable ADJ dti-1408 54 177 fragment fragment NOUN dti-1408 54 178 of of ADP dti-1408 54 179 the the DET dti-1408 54 180 peptide peptide ADJ dti-1408 54 181 precursor precursor NOUN dti-1408 54 182 of of ADP dti-1408 54 183 enkephalins enkephalin NOUN dti-1408 54 184 , , PUNCT dti-1408 54 185 and and CCONJ dti-1408 54 186 nt not PART dti-1408 54 187 - - PUNCT dti-1408 54 188 pta pta PROPN dti-1408 54 189 is be AUX dti-1408 54 190 the the DET dti-1408 54 191 stable stable ADJ dti-1408 54 192 fragment fragment NOUN dti-1408 54 193 of of ADP dti-1408 54 194 the the DET dti-1408 54 195 peptide peptide ADJ dti-1408 54 196 precursor precursor NOUN dti-1408 54 197 of of ADP dti-1408 54 198 substance substance NOUN dti-1408 55 1 p. p. NOUN dti-1408 55 2 mr mr PROPN dti-1408 55 3 - - PUNCT dti-1408 55 4 penk penk PROPN dti-1408 55 5 a a PRON dti-1408 55 6 was be AUX dti-1408 55 7 measured measure VERB dti-1408 55 8 by by ADP dti-1408 55 9 a a DET dti-1408 55 10 sensitive sensitive ADJ dti-1408 55 11 chemiluminescence chemiluminescence NOUN dti-1408 55 12 immunoassay immunoassay NOUN dti-1408 55 13 against against ADP dti-1408 55 14 amino amino ADJ dti-1408 55 15 acids acid NOUN dti-1408 55 16 119−159 119−159 NUM dti-1408 55 17 of of ADP dti-1408 55 18 the the DET dti-1408 55 19 mr mr PROPN dti-1408 55 20 - - PUNCT dti-1408 55 21 penk penk NOUN dti-1408 55 22 a a DET dti-1408 55 23 precursor precursor NOUN dti-1408 55 24 fragment fragment NOUN dti-1408 55 25 ( ( PUNCT dti-1408 55 26 brahms brahms NOUN dti-1408 55 27 gmbh).23 gmbh).23 VERB dti-1408 55 28 a a DET dti-1408 55 29 similar similar ADJ dti-1408 55 30 sensitive sensitive ADJ dti-1408 55 31 chemiluminescence chemiluminescence NOUN dti-1408 55 32 immunoassay immunoassay NOUN dti-1408 55 33 was be AUX dti-1408 55 34 developed develop VERB dti-1408 55 35 to to PART dti-1408 55 36 detect detect VERB dti-1408 55 37 amino amino ADJ dti-1408 55 38 acids acid NOUN dti-1408 55 39 1−37 1−37 PROPN dti-1408 55 40 of of ADP dti-1408 55 41 nt nt NOUN dti-1408 55 42 - - PUNCT dti-1408 55 43 pta pta PROPN dti-1408 55 44 ( ( PUNCT dti-1408 55 45 brahms brahms NOUN dti-1408 55 46 gmbh).32 gmbh).32 PROPN dti-1408 55 47 proneurotensin proneurotensin NOUN dti-1408 55 48 was be AUX dti-1408 55 49 measured measure VERB dti-1408 55 50 by by ADP dti-1408 55 51 a a DET dti-1408 55 52 recent recent ADJ dti-1408 55 53 developed developed ADJ dti-1408 55 54 chemiluminometric chemiluminometric NOUN dti-1408 55 55 sandwich sandwich NOUN dti-1408 55 56 immunoassay immunoassay PROPN dti-1408 55 57 to to PART dti-1408 55 58 detect detect VERB dti-1408 55 59 a a DET dti-1408 55 60 proneurotensin proneurotensin NOUN dti-1408 55 61 precursor precursor NOUN dti-1408 55 62 fragment fragment NOUN dti-1408 55 63 ( ( PUNCT dti-1408 55 64 pro pro X dti-1408 55 65 nt nt PROPN dti-1408 55 66 / / SYM dti-1408 55 67 nmn nmn PROPN dti-1408 55 68 1–117 1–117 NUM dti-1408 55 69 ) ) PUNCT dti-1408 55 70 ( ( PUNCT dti-1408 55 71 brahms brahms NOUN dti-1408 55 72 gmbh).33 gmbh).33 VERB dti-1408 55 73 statistical statistical ADJ dti-1408 55 74 analyses analysis NOUN dti-1408 55 75 . . PUNCT dti-1408 56 1 patients patient NOUN dti-1408 56 2 with with ADP dti-1408 56 3 valid valid ADJ dti-1408 56 4 , , PUNCT dti-1408 56 5 prevalent prevalent ADJ dti-1408 56 6 ibd ibd NOUN dti-1408 56 7 in in ADP dti-1408 56 8 the the DET dti-1408 56 9 mpm mpm NOUN dti-1408 56 10 ( ( PUNCT dti-1408 56 11 n n NOUN dti-1408 56 12 = = SYM dti-1408 56 13 22 22 NUM dti-1408 56 14 ) ) PUNCT dti-1408 56 15 and and CCONJ dti-1408 56 16 mdc mdc NOUN dti-1408 56 17 - - PUNCT dti-1408 56 18 cc cc X dti-1408 56 19 ( ( PUNCT dti-1408 56 20 n n NOUN dti-1408 56 21 = = SYM dti-1408 56 22 40 40 NUM dti-1408 56 23 ) ) PUNCT dti-1408 56 24 cohorts cohort NOUN dti-1408 56 25 were be AUX dti-1408 56 26 matched match VERB dti-1408 56 27 with with ADP dti-1408 56 28 three three NUM dti-1408 56 29 controls control NOUN dti-1408 56 30 from from ADP dti-1408 56 31 their their PRON dti-1408 56 32 own own ADJ dti-1408 56 33 cohort cohort NOUN dti-1408 56 34 . . PUNCT dti-1408 57 1 those those DET dti-1408 57 2 subjects subject NOUN dti-1408 57 3 with with ADP dti-1408 57 4 prevalent prevalent ADJ dti-1408 57 5 cardiovascular cardiovascular ADJ dti-1408 57 6 disease disease NOUN dti-1408 57 7 , , PUNCT dti-1408 57 8 diabetes diabetes NOUN dti-1408 57 9 mellitus mellitus NOUN dti-1408 57 10 , , PUNCT dti-1408 57 11 or or CCONJ dti-1408 57 12 malignancy malignancy NOUN dti-1408 57 13 prior prior ADV dti-1408 57 14 to to ADP dti-1408 57 15 the the DET dti-1408 57 16 blood blood NOUN dti-1408 57 17 sampling sampling NOUN dti-1408 57 18 were be AUX dti-1408 57 19 excluded exclude VERB dti-1408 57 20 from from ADP dti-1408 57 21 both both DET dti-1408 57 22 patients patient NOUN dti-1408 57 23 and and CCONJ dti-1408 57 24 controls control NOUN dti-1408 57 25 , , PUNCT dti-1408 57 26 as as ADP dti-1408 57 27 these these DET dti-1408 57 28 diseases disease NOUN dti-1408 57 29 http://www.la-press.com http://www.la-press.com X dti-1408 57 30 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1408 57 31 basal basal ADJ dti-1408 57 32 plasma plasma NOUN dti-1408 57 33 levels level NOUN dti-1408 57 34 of of ADP dti-1408 57 35 copeptin copeptin NOUN dti-1408 57 36 in in ADP dti-1408 57 37 ibd ibd PROPN dti-1408 57 38 23drug 23drug PUNCT dti-1408 57 39 target target NOUN dti-1408 57 40 insights insight NOUN dti-1408 57 41 2015:9 2015:9 NUM dti-1408 57 42 may may AUX dti-1408 57 43 interact interact VERB dti-1408 57 44 with with ADP dti-1408 57 45 plasma plasma NOUN dti-1408 57 46 precursor precursor NOUN dti-1408 57 47 levels.28 levels.28 NOUN dti-1408 57 48 matching matching NOUN dti-1408 57 49 was be AUX dti-1408 57 50 performed perform VERB dti-1408 57 51 considering consider VERB dti-1408 57 52 age age NOUN dti-1408 57 53 at at ADP dti-1408 57 54 baseline baseline NOUN dti-1408 57 55 , , PUNCT dti-1408 57 56 date date NOUN dti-1408 57 57 of of ADP dti-1408 57 58 inclusion inclusion NOUN dti-1408 57 59 , , PUNCT dti-1408 57 60 sex sex NOUN dti-1408 57 61 , , PUNCT dti-1408 57 62 smoking smoking NOUN dti-1408 57 63 habits habit NOUN dti-1408 57 64 , , PUNCT dti-1408 57 65 and and CCONJ dti-1408 57 66     SPACE dti-1408 57 67 bmi bmi NOUN dti-1408 57 68 . . PUNCT dti-1408 58 1 plasma plasma NOUN dti-1408 58 2 analyses analysis NOUN dti-1408 58 3 were be AUX dti-1408 58 4 not not PART dti-1408 58 5 available available ADJ dti-1408 58 6 in in ADP dti-1408 58 7 some some PRON dti-1408 58 8 of of ADP dti-1408 58 9 the the DET dti-1408 58 10 subjects subject NOUN dti-1408 58 11 in in ADP dti-1408 58 12 the the DET dti-1408 58 13 mdc mdc NOUN dti-1408 58 14 - - PUNCT dti-1408 58 15 cc cc NOUN dti-1408 58 16 , , PUNCT dti-1408 58 17 so so SCONJ dti-1408 58 18 analyses analysis NOUN dti-1408 58 19 were be AUX dti-1408 58 20 measured measure VERB dti-1408 58 21 in in ADP dti-1408 58 22 28 28 NUM dti-1408 58 23 or or CCONJ dti-1408 58 24 34 34 NUM dti-1408 58 25 prevalent prevalent ADJ dti-1408 58 26 patients patient NOUN dti-1408 58 27 with with ADP dti-1408 58 28 ibd ibd PROPN dti-1408 58 29 and and CCONJ dti-1408 58 30 in in ADP dti-1408 58 31 106 106 NUM dti-1408 58 32 or or CCONJ dti-1408 58 33 115 115 NUM dti-1408 58 34 controls control NOUN dti-1408 58 35 , , PUNCT dti-1408 58 36 respectively respectively ADV dti-1408 58 37 . . PUNCT dti-1408 59 1 as as SCONJ dti-1408 59 2 plasma plasma NOUN dti-1408 59 3 analyses analysis NOUN dti-1408 59 4 were be AUX dti-1408 59 5 not not PART dti-1408 59 6 available available ADJ dti-1408 59 7 in in ADP dti-1408 59 8 several several ADJ dti-1408 59 9 of of ADP dti-1408 59 10 the the DET dti-1408 59 11 few few ADJ dti-1408 59 12 incidental incidental ADJ dti-1408 59 13 cases case NOUN dti-1408 59 14 , , PUNCT dti-1408 59 15 these these PRON dti-1408 59 16 were be AUX dti-1408 59 17 omitted omit VERB dti-1408 59 18 from from ADP dti-1408 59 19 statistical statistical ADJ dti-1408 59 20 calculations calculation NOUN dti-1408 59 21 . . PUNCT dti-1408 60 1 all all DET dti-1408 60 2 calculations calculation NOUN dti-1408 60 3 were be AUX dti-1408 60 4 performed perform VERB dti-1408 60 5 with with ADP dti-1408 60 6 the the DET dti-1408 60 7 spss spss PROPN dti-1408 60 8 version version PROPN dti-1408 60 9 22 22 NUM dti-1408 60 10 ( ( PUNCT dti-1408 60 11 statistical statistical ADJ dti-1408 60 12 package package NOUN dti-1408 60 13 for for ADP dti-1408 60 14 the the DET dti-1408 60 15 social social ADJ dti-1408 60 16 sciences sciences PROPN dti-1408 60 17 , , PUNCT dti-1408 60 18 ibm ibm PROPN dti-1408 60 19 corporation corporation NOUN dti-1408 60 20 ) ) PUNCT dti-1408 60 21 . . PUNCT dti-1408 61 1 calculations calculation NOUN dti-1408 61 2 were be AUX dti-1408 61 3 performed perform VERB dti-1408 61 4 separately separately ADV dti-1408 61 5 for for ADP dti-1408 61 6 the the DET dti-1408 61 7 two two NUM dti-1408 61 8 cohorts cohort NOUN dti-1408 61 9 compared compare VERB dti-1408 61 10 with with ADP dti-1408 61 11 controls control NOUN dti-1408 61 12 . . PUNCT dti-1408 62 1 furthermore furthermore ADV dti-1408 62 2 , , PUNCT dti-1408 62 3 the the DET dti-1408 62 4 two two NUM dti-1408 62 5 cohorts cohort NOUN dti-1408 62 6 were be AUX dti-1408 62 7 added add VERB dti-1408 62 8 in in ADP dti-1408 62 9 an an DET dti-1408 62 10 attempt attempt NOUN dti-1408 62 11 to to PART dti-1408 62 12 reach reach VERB dti-1408 62 13 a a DET dti-1408 62 14 greater great ADJ dti-1408 62 15 cohort cohort NOUN dti-1408 62 16 . . PUNCT dti-1408 63 1 as as SCONJ dti-1408 63 2 age age NOUN dti-1408 63 3 differed differ VERB dti-1408 63 4 between between ADP dti-1408 63 5 mpm mpm NOUN dti-1408 63 6 and and CCONJ dti-1408 63 7 mdc mdc NOUN dti-1408 63 8 - - PUNCT dti-1408 63 9 cc cc NOUN dti-1408 63 10 , , PUNCT dti-1408 63 11 and and CCONJ dti-1408 63 12 several several ADJ dti-1408 63 13 peptide peptide NOUN dti-1408 63 14 analyses analysis NOUN dti-1408 63 15 correlated correlate VERB dti-1408 63 16 with with ADP dti-1408 63 17 age age NOUN dti-1408 63 18 , , PUNCT dti-1408 63 19 the the DET dti-1408 63 20 values value NOUN dti-1408 63 21 were be AUX dti-1408 63 22 age age NOUN dti-1408 63 23 - - PUNCT dti-1408 63 24 standardized standardized ADJ dti-1408 63 25 using use VERB dti-1408 63 26 a a DET dti-1408 63 27 linear linear ADJ dti-1408 63 28 regression regression NOUN dti-1408 63 29 model model NOUN dti-1408 63 30 into into ADP dti-1408 63 31 which which PRON dti-1408 63 32 age age NOUN dti-1408 63 33 was be AUX dti-1408 63 34 added add VERB dti-1408 63 35 as as ADP dti-1408 63 36 a a DET dti-1408 63 37 covariate covariate NOUN dti-1408 63 38 and and CCONJ dti-1408 63 39 the the DET dti-1408 63 40 variables variable NOUN dti-1408 63 41 were be AUX dti-1408 63 42 expressed express VERB dti-1408 63 43 as as ADP dti-1408 63 44 z z NOUN dti-1408 63 45 - - NOUN dti-1408 63 46 scores score NOUN dti-1408 63 47 . . PUNCT dti-1408 64 1 those those DET dti-1408 64 2 precursors precursor NOUN dti-1408 64 3 that that PRON dti-1408 64 4 did do AUX dti-1408 64 5 not not PART dti-1408 64 6 differ differ VERB dti-1408 64 7 between between ADP dti-1408 64 8 the the DET dti-1408 64 9 mpm mpm NOUN dti-1408 64 10 and and CCONJ dti-1408 64 11 mdc mdc NOUN dti-1408 64 12 - - PUNCT dti-1408 64 13 cc cc NOUN dti-1408 64 14 cohorts cohort NOUN dti-1408 64 15 were be AUX dti-1408 64 16 copeptin copeptin NOUN dti-1408 64 17 ( ( PUNCT dti-1408 64 18 p p X dti-1408 64 19 = = NOUN dti-1408 64 20 0.623 0.623 NUM dti-1408 64 21 ) ) PUNCT dti-1408 64 22 , , PUNCT dti-1408 64 23 mr mr PROPN dti-1408 64 24 - - PUNCT dti-1408 64 25 proadm proadm PROPN dti-1408 64 26 ( ( PUNCT dti-1408 64 27 p p NOUN dti-1408 64 28 = = NOUN dti-1408 64 29 0.058 0.058 NUM dti-1408 64 30 ) ) PUNCT dti-1408 64 31 , , PUNCT dti-1408 64 32 and and CCONJ dti-1408 64 33 mr mr PROPN dti-1408 64 34 - - PUNCT dti-1408 64 35 proanp proanp PROPN dti-1408 64 36 ( ( PUNCT dti-1408 64 37 p p X dti-1408 64 38 = = NOUN dti-1408 64 39 0.500 0.500 NUM dti-1408 64 40 ) ) PUNCT dti-1408 64 41 , , PUNCT dti-1408 64 42 which which PRON dti-1408 64 43 were be AUX dti-1408 64 44 thus thus ADV dti-1408 64 45 calculated calculate VERB dti-1408 64 46 together together ADV dti-1408 64 47 . . PUNCT dti-1408 65 1 values value NOUN dti-1408 65 2 are be AUX dti-1408 65 3 given give VERB dti-1408 65 4 as as ADP dti-1408 65 5 median median PROPN dti-1408 65 6 [ [ X dti-1408 65 7 interquartile interquartile ADJ dti-1408 65 8 range range NOUN dti-1408 65 9 ( ( PUNCT dti-1408 65 10 iqr iqr NOUN dti-1408 65 11 ) ) PUNCT dti-1408 65 12 ] ] PUNCT dti-1408 65 13 or or CCONJ dti-1408 65 14 mean mean NOUN dti-1408 65 15 ± ± NUM dti-1408 65 16 standard standard ADJ dti-1408 65 17 deviation deviation NOUN dti-1408 65 18 ( ( PUNCT dti-1408 65 19 sd sd NOUN dti-1408 65 20 ) ) PUNCT dti-1408 65 21 . . PUNCT dti-1408 66 1 the the DET dti-1408 66 2 mann mann PROPN dti-1408 66 3 – – PUNCT dti-1408 66 4 whitney whitney PROPN dti-1408 66 5 u u NOUN dti-1408 66 6 - - NOUN dti-1408 66 7 test test NOUN dti-1408 66 8 was be AUX dti-1408 66 9 used use VERB dti-1408 66 10 to to PART dti-1408 66 11 compare compare VERB dti-1408 66 12 the the DET dti-1408 66 13 differences difference NOUN dti-1408 66 14 in in ADP dti-1408 66 15 precursor precursor NOUN dti-1408 66 16 levels level NOUN dti-1408 66 17 between between ADP dti-1408 66 18 patients patient NOUN dti-1408 66 19 and and CCONJ dti-1408 66 20 controls control NOUN dti-1408 66 21 and and CCONJ dti-1408 66 22 for for ADP dti-1408 66 23 subgroup subgroup NOUN dti-1408 66 24 analyses analysis NOUN dti-1408 66 25 within within ADP dti-1408 66 26 the the DET dti-1408 66 27 ibd ibd PROPN dti-1408 66 28 group group NOUN dti-1408 66 29 . . PUNCT dti-1408 67 1 fisher fisher PROPN dti-1408 67 2 ’s ’s PART dti-1408 67 3 exact exact ADJ dti-1408 67 4 test test NOUN dti-1408 67 5 was be AUX dti-1408 67 6 used use VERB dti-1408 67 7 for for ADP dti-1408 67 8 dichotomous dichotomous ADJ dti-1408 67 9 variables variable NOUN dti-1408 67 10 . . PUNCT dti-1408 68 1 the the DET dti-1408 68 2 spearman spearman NOUN dti-1408 68 3 rank rank NOUN dti-1408 68 4 correlation correlation NOUN dti-1408 68 5 test test NOUN dti-1408 68 6 was be AUX dti-1408 68 7 used use VERB dti-1408 68 8 for for ADP dti-1408 68 9 correlations correlation NOUN dti-1408 68 10 between between ADP dti-1408 68 11 precursor precursor NOUN dti-1408 68 12 and and CCONJ dti-1408 68 13 disease disease NOUN dti-1408 68 14 duration duration NOUN dti-1408 68 15 . . PUNCT dti-1408 69 1 p p X dti-1408 69 2     SPACE dti-1408 69 3   NOUN dti-1408 69 4     SPACE dti-1408 69 5 0.05 0.05 NUM dti-1408 69 6 was be AUX dti-1408 69 7 considered consider VERB dti-1408 69 8 statistically statistically ADV dti-1408 69 9 significant significant ADJ dti-1408 69 10 . . PUNCT dti-1408 70 1 results result VERB dti-1408 70 2 patient patient ADJ dti-1408 70 3 characteristics characteristic NOUN dti-1408 70 4 . . PUNCT dti-1408 71 1 mpm mpm NOUN dti-1408 71 2 . . PUNCT dti-1408 72 1 the the DET dti-1408 72 2 basal basal ADJ dti-1408 72 3 characteristics characteristic NOUN dti-1408 72 4 are be AUX dti-1408 72 5 described describe VERB dti-1408 72 6 in in ADP dti-1408 72 7 table table NOUN dti-1408 72 8 1 1 NUM dti-1408 72 9 . . PUNCT dti-1408 73 1 the the DET dti-1408 73 2 22 22 NUM dti-1408 73 3 included include VERB dti-1408 73 4 patients patient NOUN dti-1408 73 5 were be AUX dti-1408 73 6 in in ADP dti-1408 73 7 an an DET dti-1408 73 8 inactive inactive ADJ dti-1408 73 9 phase phase NOUN dti-1408 73 10 during during ADP dti-1408 73 11 their their PRON dti-1408 73 12 enrollment enrollment NOUN dti-1408 73 13 in in ADP dti-1408 73 14 the the DET dti-1408 73 15 study study NOUN dti-1408 73 16 . . PUNCT dti-1408 74 1 disease disease NOUN dti-1408 74 2 duration duration NOUN dti-1408 74 3 was be AUX dti-1408 74 4 25.4 25.4 NUM dti-1408 74 5     SPACE dti-1408 74 6 ± ± NOUN dti-1408 74 7     SPACE dti-1408 74 8 13.4 13.4 NUM dti-1408 74 9     SPACE dti-1408 74 10 years year NOUN dti-1408 74 11 . . PUNCT dti-1408 75 1 none none NOUN dti-1408 75 2 of of ADP dti-1408 75 3 the the DET dti-1408 75 4 patients patient NOUN dti-1408 75 5 was be AUX dti-1408 75 6 receiving receive VERB dti-1408 75 7 acute acute NOUN dti-1408 75 8 therapy therapy NOUN dti-1408 75 9 , , PUNCT dti-1408 75 10 but but CCONJ dti-1408 75 11 six six NUM dti-1408 75 12 ( ( PUNCT dti-1408 75 13 27 27 NUM dti-1408 75 14 % % NOUN dti-1408 75 15 ) ) PUNCT dti-1408 75 16 were be AUX dti-1408 75 17 on on ADP dti-1408 75 18 continuous continuous ADJ dti-1408 75 19 treatment treatment NOUN dti-1408 75 20 with with ADP dti-1408 75 21 anti anti ADJ dti-1408 75 22 - - ADJ dti-1408 75 23 inflammatory inflammatory ADJ dti-1408 75 24 or or CCONJ dti-1408 75 25 immune immune NOUN dti-1408 75 26 - - PUNCT dti-1408 75 27 modulating modulate VERB dti-1408 75 28 therapy therapy NOUN dti-1408 75 29 . . PUNCT dti-1408 76 1 twelve twelve NUM dti-1408 76 2 patients patient NOUN dti-1408 76 3 ( ( PUNCT dti-1408 76 4 54 54 NUM dti-1408 76 5 % % NOUN dti-1408 76 6 ) ) PUNCT dti-1408 76 7 had have AUX dti-1408 76 8 undergone undergo VERB dti-1408 76 9 intestinal intestinal ADJ dti-1408 76 10 resections resection NOUN dti-1408 76 11 due due ADJ dti-1408 76 12 to to ADP dti-1408 76 13 ibd ibd NOUN dti-1408 76 14 , , PUNCT dti-1408 76 15 and and CCONJ dti-1408 76 16 10 10 NUM dti-1408 76 17 of of ADP dti-1408 76 18 the the DET dti-1408 76 19 patients patient NOUN dti-1408 76 20 ( ( PUNCT dti-1408 76 21 46 46 NUM dti-1408 76 22 % % NOUN dti-1408 76 23 ) ) PUNCT dti-1408 76 24 had have VERB dti-1408 76 25 extensive extensive ADJ dti-1408 76 26 disease disease NOUN dti-1408 76 27 . . PUNCT dti-1408 77 1 apart apart ADV dti-1408 77 2 from from ADP dti-1408 77 3 ibd ibd PROPN dti-1408 77 4 , , PUNCT dti-1408 77 5 six six NUM dti-1408 77 6 patients patient NOUN dti-1408 77 7 also also ADV dti-1408 77 8 suffered suffer VERB dti-1408 77 9 from from ADP dti-1408 77 10 hypertension hypertension NOUN dti-1408 77 11 and and CCONJ dti-1408 77 12 four four NUM dti-1408 77 13 from from ADP dti-1408 77 14 nephrolithiasis nephrolithiasis NOUN dti-1408 77 15 . . PUNCT dti-1408 78 1 sporadic sporadic ADJ dti-1408 78 2 cases case NOUN dti-1408 78 3 of of ADP dti-1408 78 4 asthma asthma NOUN dti-1408 78 5 bronchialis bronchiali NOUN dti-1408 78 6 , , PUNCT dti-1408 78 7 bile bile NOUN dti-1408 78 8 stones stone NOUN dti-1408 78 9 , , PUNCT dti-1408 78 10 chronic chronic ADJ dti-1408 78 11 obstructive obstructive ADJ dti-1408 78 12 pulmonary pulmonary ADJ dti-1408 78 13 disease disease NOUN dti-1408 78 14 ( ( PUNCT dti-1408 78 15 copd copd PROPN dti-1408 78 16 ) ) PUNCT dti-1408 78 17 , , PUNCT dti-1408 78 18 dyspepsia dyspepsia NOUN dti-1408 78 19 , , PUNCT dti-1408 78 20 hyperlipidemia hyperlipidemia NOUN dti-1408 78 21 , , PUNCT dti-1408 78 22 hypothyroidism hypothyroidism NOUN dti-1408 78 23 , , PUNCT dti-1408 78 24 migraine migraine NOUN dti-1408 78 25 , , PUNCT dti-1408 78 26 primary primary ADJ dti-1408 78 27 sjögren sjögren PROPN dti-1408 78 28 ’s ’s PART dti-1408 78 29 syndrome syndrome NOUN dti-1408 78 30 , , PUNCT dti-1408 78 31 reflux reflux NOUN dti-1408 78 32 , , PUNCT dti-1408 78 33 and and CCONJ dti-1408 78 34 renal renal ADJ dti-1408 78 35 insufficiency insufficiency NOUN dti-1408 78 36 were be AUX dti-1408 78 37 found find VERB dti-1408 78 38 . . PUNCT dti-1408 79 1 mdc mdc NOUN dti-1408 79 2 - - PUNCT dti-1408 79 3 cc cc NOUN dti-1408 79 4 . . PUNCT dti-1408 80 1 all all DET dti-1408 80 2 40 40 NUM dti-1408 80 3 included include VERB dti-1408 80 4 patients patient NOUN dti-1408 80 5 with with ADP dti-1408 80 6 prevalent prevalent ADJ dti-1408 80 7 ibd ibd PROPN dti-1408 80 8 were be AUX dti-1408 80 9 in in ADP dti-1408 80 10 an an DET dti-1408 80 11 inactive inactive ADJ dti-1408 80 12 state state NOUN dti-1408 80 13 during during ADP dti-1408 80 14 enrollment enrollment NOUN dti-1408 80 15 in in ADP dti-1408 80 16 the the DET dti-1408 80 17 study study NOUN dti-1408 80 18 . . PUNCT dti-1408 81 1 disease disease NOUN dti-1408 81 2 duration duration NOUN dti-1408 81 3 was be AUX dti-1408 81 4 13.1 13.1 NUM dti-1408 81 5 ± ± NUM dti-1408 81 6 10.0 10.0 NUM dti-1408 81 7     SPACE dti-1408 81 8 years year NOUN dti-1408 81 9 ( ( PUNCT dti-1408 81 10 table table NOUN dti-1408 81 11 1 1 NUM dti-1408 81 12 ) ) PUNCT dti-1408 81 13 . . PUNCT dti-1408 82 1 none none NOUN dti-1408 82 2 was be AUX dti-1408 82 3 undergoing undergo VERB dti-1408 82 4 acute acute NOUN dti-1408 82 5 therapy therapy NOUN dti-1408 82 6 , , PUNCT dti-1408 82 7 and and CCONJ dti-1408 82 8 only only ADV dti-1408 82 9 three three NUM dti-1408 82 10 patients patient NOUN dti-1408 82 11 ( ( PUNCT dti-1408 82 12 8 8 NUM dti-1408 82 13 % % NOUN dti-1408 82 14 ) ) PUNCT dti-1408 82 15 were be AUX dti-1408 82 16 on on ADP dti-1408 82 17 continuous continuous ADJ dti-1408 82 18 treatment treatment NOUN dti-1408 82 19 with with ADP dti-1408 82 20 anti anti ADJ dti-1408 82 21 - - ADJ dti-1408 82 22 inflammatory inflammatory ADJ dti-1408 82 23 or or CCONJ dti-1408 82 24 immunemodulating immunemodulating NOUN dti-1408 82 25 therapy therapy NOUN dti-1408 82 26 . . PUNCT dti-1408 83 1 thirteen thirteen NUM dti-1408 83 2 patients patient NOUN dti-1408 83 3 ( ( PUNCT dti-1408 83 4 32 32 NUM dti-1408 83 5 % % NOUN dti-1408 83 6 ) ) PUNCT dti-1408 83 7 had have AUX dti-1408 83 8 undergone undergo VERB dti-1408 83 9 intestinal intestinal ADJ dti-1408 83 10 resections resection NOUN dti-1408 83 11 due due ADJ dti-1408 83 12 to to ADP dti-1408 83 13 ibd ibd NOUN dti-1408 83 14 , , PUNCT dti-1408 83 15 whereas whereas SCONJ dti-1408 83 16 18 18 NUM dti-1408 83 17 patients patient NOUN dti-1408 83 18 ( ( PUNCT dti-1408 83 19 45 45 NUM dti-1408 83 20 % % NOUN dti-1408 83 21 ) ) PUNCT dti-1408 83 22 had have VERB dti-1408 83 23 an an DET dti-1408 83 24 extensive extensive ADJ dti-1408 83 25 distribution distribution NOUN dti-1408 83 26 of of ADP dti-1408 83 27 the the DET dti-1408 83 28 disease disease NOUN dti-1408 83 29 . . PUNCT dti-1408 84 1 sporadic sporadic ADJ dti-1408 84 2 concomitant concomitant ADJ dti-1408 84 3 diseases disease NOUN dti-1408 84 4 were be AUX dti-1408 84 5 present present ADJ dti-1408 84 6 in in ADP dti-1408 84 7 the the DET dti-1408 84 8 form form NOUN dti-1408 84 9 of of ADP dti-1408 84 10 asthma asthma NOUN dti-1408 84 11 bronchialis bronchiali NOUN dti-1408 84 12 , , PUNCT dti-1408 84 13 copd copd NOUN dti-1408 84 14 , , PUNCT dti-1408 84 15 duodenal duodenal ADJ dti-1408 84 16 ulceration ulceration NOUN dti-1408 84 17 , , PUNCT dti-1408 84 18 dyspepsia dyspepsia PROPN dti-1408 84 19 , , PUNCT dti-1408 84 20 hiatal hiatal ADJ dti-1408 84 21 hernia hernia NOUN dti-1408 84 22 , , PUNCT dti-1408 84 23 hypertension hypertension NOUN dti-1408 84 24 , , PUNCT dti-1408 84 25 hypothyroidism hypothyroidism NOUN dti-1408 84 26 , , PUNCT dti-1408 84 27 inguinal inguinal ADJ dti-1408 84 28 hernia hernia NOUN dti-1408 84 29 , , PUNCT dti-1408 84 30 ankylosing ankylose VERB dti-1408 84 31 spondylitis spondylitis NOUN dti-1408 84 32 , , PUNCT dti-1408 84 33 and and CCONJ dti-1408 84 34 venous venous ADJ dti-1408 84 35 thrombosis thrombosis NOUN dti-1408 84 36 . . PUNCT dti-1408 85 1 precursor precursor NOUN dti-1408 85 2 analyses analysis NOUN dti-1408 85 3 . . PUNCT dti-1408 86 1 when when SCONJ dti-1408 86 2 precursor precursor NOUN dti-1408 86 3 analyses analysis NOUN dti-1408 86 4 were be AUX dti-1408 86 5 done do VERB dti-1408 86 6 together together ADV dti-1408 86 7 , , PUNCT dti-1408 86 8 the the DET dti-1408 86 9 higher high ADJ dti-1408 86 10 plasma plasma NOUN dti-1408 86 11 level level NOUN dti-1408 86 12 of of ADP dti-1408 86 13 copeptin copeptin NOUN dti-1408 86 14 was be AUX dti-1408 86 15 the the DET dti-1408 86 16 only only ADJ dti-1408 86 17 significant significant ADJ dti-1408 86 18 difference difference NOUN dti-1408 86 19 in in ADP dti-1408 86 20 plasma plasma NOUN dti-1408 86 21 measurements measurement NOUN dti-1408 86 22 between between ADP dti-1408 86 23 patients patient NOUN dti-1408 86 24 and and CCONJ dti-1408 86 25 controls control NOUN dti-1408 86 26 ( ( PUNCT dti-1408 86 27 table table NOUN dti-1408 86 28 2 2 NUM dti-1408 86 29 ) ) PUNCT dti-1408 86 30 . . PUNCT dti-1408 87 1 patients patient NOUN dti-1408 87 2 who who PRON dti-1408 87 3 had have AUX dti-1408 87 4 undergone undergo VERB dti-1408 87 5 bowel bowel NOUN dti-1408 87 6 resection resection NOUN dti-1408 87 7 had have VERB dti-1408 87 8 higher high ADJ dti-1408 87 9 plasma plasma NOUN dti-1408 87 10 levels level NOUN dti-1408 87 11 of of ADP dti-1408 87 12 copeptin copeptin NOUN dti-1408 87 13 compared compare VERB dti-1408 87 14 with with ADP dti-1408 87 15 unresected unresected ADJ dti-1408 87 16 patients patient NOUN dti-1408 87 17 [ [ X dti-1408 87 18 10.25 10.25 NUM dti-1408 87 19 ( ( PUNCT dti-1408 87 20 7.94–13.75 7.94–13.75 PROPN dti-1408 87 21 ) ) PUNCT dti-1408 87 22 and and CCONJ dti-1408 87 23 6.33 6.33 NUM dti-1408 87 24 ( ( PUNCT dti-1408 87 25 4.92–9.52 4.92–9.52 NUM dti-1408 87 26 ) ) PUNCT dti-1408 87 27 pmol pmol PROPN dti-1408 87 28 / / SYM dti-1408 87 29 l l NOUN dti-1408 87 30 , , PUNCT dti-1408 87 31 respectively respectively ADV dti-1408 87 32 , , PUNCT dti-1408 87 33 p p X dti-1408 87 34 = = PROPN dti-1408 87 35 0.020 0.020 NUM dti-1408 87 36 ] ] PUNCT dti-1408 87 37 . . PUNCT dti-1408 88 1 when when SCONJ dti-1408 88 2 the the DET dti-1408 88 3 patients patient NOUN dti-1408 88 4 with with ADP dti-1408 88 5 a a DET dti-1408 88 6 history history NOUN dti-1408 88 7 of of ADP dti-1408 88 8 bowel bowel NOUN dti-1408 88 9 resection resection NOUN dti-1408 88 10 were be AUX dti-1408 88 11 excluded exclude VERB dti-1408 88 12 ( ( PUNCT dti-1408 88 13 n n NOUN dti-1408 88 14 = = NUM dti-1408 88 15 23 23 NUM dti-1408 88 16 ) ) PUNCT dti-1408 88 17 together together ADV dti-1408 88 18 with with ADP dti-1408 88 19 their their PRON dti-1408 88 20 matched match VERB dti-1408 88 21 controls control NOUN dti-1408 88 22 , , PUNCT dti-1408 88 23 there there PRON dti-1408 88 24 was be VERB dti-1408 88 25 no no DET dti-1408 88 26 difference difference NOUN dti-1408 88 27 in in ADP dti-1408 88 28 copeptin copeptin NOUN dti-1408 88 29 levels level NOUN dti-1408 88 30 between between ADP dti-1408 88 31 patients patient NOUN dti-1408 88 32 and and CCONJ dti-1408 88 33 controls control VERB dti-1408 88 34 [ [ PUNCT dti-1408 88 35 6.33 6.33 NUM dti-1408 88 36 ( ( PUNCT dti-1408 88 37 4.92–9.52 4.92–9.52 NUM dti-1408 88 38 ) ) PUNCT dti-1408 88 39 and and CCONJ dti-1408 88 40 5.81 5.81 NUM dti-1408 88 41 ( ( PUNCT dti-1408 88 42 3.52–9.64 3.52–9.64 NUM dti-1408 88 43 ) ) PUNCT dti-1408 88 44 pmol pmol PROPN dti-1408 88 45 / / SYM dti-1408 88 46 l l NOUN dti-1408 88 47 , , PUNCT dti-1408 88 48 respectively respectively ADV dti-1408 88 49 , , PUNCT dti-1408 88 50 p p X dti-1408 88 51 = = PROPN dti-1408 88 52 0.501 0.501 NUM dti-1408 88 53 ] ] PUNCT dti-1408 88 54 . . PUNCT dti-1408 89 1 there there PRON dti-1408 89 2 was be VERB dti-1408 89 3 no no DET dti-1408 89 4 diftable diftable ADJ dti-1408 89 5 1 1 NUM dti-1408 89 6 . . PUNCT dti-1408 90 1 patient patient ADJ dti-1408 90 2 characteristics characteristic NOUN dti-1408 90 3 of of ADP dti-1408 90 4 the the DET dti-1408 90 5 two two NUM dti-1408 90 6 cohorts cohort NOUN dti-1408 90 7 . . PUNCT dti-1408 91 1 prevalent prevalent ADJ dti-1408 91 2 ibd ibd PROPN dti-1408 91 3 mpm mpm PROPN dti-1408 91 4 n n NOUN dti-1408 91 5 = = SYM dti-1408 91 6 22 22 NUM dti-1408 91 7 prevalent prevalent PROPN dti-1408 91 8 ibd ibd PROPN dti-1408 91 9 mdc mdc PROPN dti-1408 91 10 - - PUNCT dti-1408 91 11 cc cc NOUN dti-1408 91 12 n n NOUN dti-1408 91 13 = = NUM dti-1408 91 14 40 40 NUM dti-1408 91 15 p p ADJ dti-1408 91 16 - - PUNCT dti-1408 91 17 value value NOUN dti-1408 91 18 age age NOUN dti-1408 91 19 ( ( PUNCT dti-1408 91 20 years year NOUN dti-1408 91 21 ) ) PUNCT dti-1408 91 22 69.7 69.7 NUM dti-1408 91 23 ± ± NUM dti-1408 91 24 7.2 7.2 NUM dti-1408 91 25 56.0 56.0 NUM dti-1408 91 26 ± ± NUM dti-1408 91 27 6.5 6.5 NUM dti-1408 91 28 0.0001 0.0001 NOUN dti-1408 91 29 sex sex NOUN dti-1408 91 30 ( ( PUNCT dti-1408 91 31 male male NOUN dti-1408 91 32 / / SYM dti-1408 91 33 female female NOUN dti-1408 91 34 ) ) PUNCT dti-1408 91 35 12/10 12/10 NUM dti-1408 91 36 19/21 19/21 NUM dti-1408 91 37 0.791 0.791 NUM dti-1408 91 38 smoking smoking NOUN dti-1408 91 39 ( ( PUNCT dti-1408 91 40 n n CCONJ dti-1408 91 41 , , PUNCT dti-1408 91 42 % % INTJ dti-1408 91 43 ) ) PUNCT dti-1408 91 44 0.182 0.182 NUM dti-1408 91 45 missing miss VERB dti-1408 91 46 values value NOUN dti-1408 91 47 ( ( PUNCT dti-1408 91 48 n n CCONJ dti-1408 91 49 ) ) PUNCT dti-1408 91 50 2 2 NUM dti-1408 91 51 smokers smoker NOUN dti-1408 91 52 11 11 NUM dti-1408 91 53 ( ( PUNCT dti-1408 91 54 50 50 NUM dti-1408 91 55 ) ) PUNCT dti-1408 91 56 12 12 NUM dti-1408 91 57 ( ( PUNCT dti-1408 91 58 30 30 NUM dti-1408 91 59 ) ) PUNCT dti-1408 91 60 nonsmokers nonsmoker NOUN dti-1408 91 61 11 11 NUM dti-1408 91 62 ( ( PUNCT dti-1408 91 63 50 50 NUM dti-1408 91 64 ) ) PUNCT dti-1408 91 65 26 26 NUM dti-1408 91 66 ( ( PUNCT dti-1408 91 67 65 65 NUM dti-1408 91 68 ) ) PUNCT dti-1408 91 69 bmi bmi NOUN dti-1408 91 70 ( ( PUNCT dti-1408 91 71 kg kg NOUN dti-1408 91 72 / / SYM dti-1408 91 73 m2 m2 PROPN dti-1408 91 74 ) ) PUNCT dti-1408 91 75 23.8 23.8 NUM dti-1408 91 76 ± ± NUM dti-1408 91 77 3.8 3.8 NUM dti-1408 91 78 24.8 24.8 NUM dti-1408 91 79 ± ± NUM dti-1408 91 80 3.5 3.5 NUM dti-1408 91 81 0.237 0.237 NUM dti-1408 91 82 duration duration NOUN dti-1408 91 83 of of ADP dti-1408 91 84 ibd ibd PROPN dti-1408 91 85 ( ( PUNCT dti-1408 91 86 years year NOUN dti-1408 91 87 ) ) PUNCT dti-1408 91 88 25.4 25.4 NUM dti-1408 91 89 ± ± NUM dti-1408 91 90 13.4 13.4 NUM dti-1408 91 91 13.1 13.1 NUM dti-1408 91 92 ± ± NUM dti-1408 91 93 10.0 10.0 NUM dti-1408 91 94 0.0001 0.0001 VERB dti-1408 91 95 missing miss VERB dti-1408 91 96 values value NOUN dti-1408 91 97 ( ( PUNCT dti-1408 91 98 n n CCONJ dti-1408 91 99 ) ) PUNCT dti-1408 91 100 2 2 NUM dti-1408 91 101 crohn crohn PROPN dti-1408 91 102 ’s ’s PART dti-1408 91 103 disease disease NOUN dti-1408 91 104 / / SYM dti-1408 91 105 ulcerative ulcerative ADJ dti-1408 91 106 colitis colitis NOUN dti-1408 91 107 8/14 8/14 NUM dti-1408 91 108 19/21 19/21 NUM dti-1408 91 109 0.435 0.435 NUM dti-1408 91 110 notes note NOUN dti-1408 91 111 : : PUNCT dti-1408 91 112 n n X dti-1408 91 113 ( ( PUNCT dti-1408 91 114 % % INTJ dti-1408 91 115 ) ) PUNCT dti-1408 91 116 = = NOUN dti-1408 91 117 number number NOUN dti-1408 91 118 and and CCONJ dti-1408 91 119 percentage percentage NOUN dti-1408 91 120 of of ADP dti-1408 91 121 cases case NOUN dti-1408 91 122 . . PUNCT dti-1408 92 1 values value NOUN dti-1408 92 2 are be AUX dti-1408 92 3 given give VERB dti-1408 92 4 as as ADP dti-1408 92 5 mean mean PROPN dti-1408 92 6 ± ± NUM dti-1408 92 7 standard standard ADJ dti-1408 92 8 deviation deviation NOUN dti-1408 92 9 ( ( PUNCT dti-1408 92 10 sd sd NOUN dti-1408 92 11 ) ) PUNCT dti-1408 92 12 . . PUNCT dti-1408 93 1 mann mann PROPN dti-1408 93 2 – – PUNCT dti-1408 93 3 whitney whitney PROPN dti-1408 93 4 u u NOUN dti-1408 93 5 - - NOUN dti-1408 93 6 test test NOUN dti-1408 93 7 or or CCONJ dti-1408 93 8 fisher fisher PROPN dti-1408 93 9 ’s ’s PART dti-1408 93 10 exact exact ADJ dti-1408 93 11 test test NOUN dti-1408 93 12 . . PUNCT dti-1408 94 1 p p X dti-1408 94 2   NOUN dti-1408 94 3 0.05 0.05 NUM dti-1408 94 4 was be AUX dti-1408 94 5 considered consider VERB dti-1408 94 6 statistically statistically ADV dti-1408 94 7 significant significant ADJ dti-1408 94 8 . . PUNCT dti-1408 95 1 abbreviations abbreviation NOUN dti-1408 95 2 : : PUNCT dti-1408 95 3 bmi bmi NOUN dti-1408 95 4 , , PUNCT dti-1408 95 5 body body NOUN dti-1408 95 6 mass mass PROPN dti-1408 95 7 index index NOUN dti-1408 95 8 ; ; PUNCT dti-1408 95 9 ibd ibd NOUN dti-1408 95 10 , , PUNCT dti-1408 95 11 inflammatory inflammatory ADJ dti-1408 95 12 bowel bowel NOUN dti-1408 95 13 syndrome syndrome NOUN dti-1408 95 14 ; ; PUNCT dti-1408 95 15 mdc mdc NOUN dti-1408 95 16 - - PUNCT dti-1408 95 17 cc cc PROPN dti-1408 95 18 , , PUNCT dti-1408 95 19 malmö malmö PROPN dti-1408 95 20 diet diet PROPN dti-1408 95 21 and and CCONJ dti-1408 95 22 cancer cancer NOUN dti-1408 95 23 study study NOUN dti-1408 95 24 cardiovascular cardiovascular ADJ dti-1408 95 25 cohort cohort NOUN dti-1408 95 26 ; ; PUNCT dti-1408 95 27 mpm mpm PROPN dti-1408 95 28 , , PUNCT dti-1408 95 29 malmö malmö PROPN dti-1408 95 30 preventive preventive ADJ dti-1408 95 31 medicine medicine NOUN dti-1408 95 32 . . PUNCT dti-1408 96 1 http://www.la-press.com http://www.la-press.com X dti-1408 97 1 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 AUX dti-1408 97 2 ohlsson ohlsson ADJ dti-1408 97 3 and and CCONJ dti-1408 97 4 melander melander VERB dti-1408 97 5 24 24 NUM dti-1408 97 6 drug drug NOUN dti-1408 97 7 target target NOUN dti-1408 97 8 insights insight NOUN dti-1408 97 9 2015:9 2015:9 DET dti-1408 97 10 ference ference NOUN dti-1408 97 11 in in ADP dti-1408 97 12 copeptin copeptin NOUN dti-1408 97 13 levels level NOUN dti-1408 97 14 whether whether SCONJ dti-1408 97 15 or or CCONJ dti-1408 97 16 not not PART dti-1408 97 17 the the DET dti-1408 97 18 patients patient NOUN dti-1408 97 19 suffered suffer VERB dti-1408 97 20 from from ADP dti-1408 97 21 crohn crohn PROPN dti-1408 97 22 ’s ’s PART dti-1408 97 23 disease disease NOUN dti-1408 97 24 or or CCONJ dti-1408 97 25 ulcerative ulcerative ADJ dti-1408 97 26 colitis colitis NOUN dti-1408 97 27 [ [ X dti-1408 97 28 7.19 7.19 NUM dti-1408 97 29 ( ( PUNCT dti-1408 97 30 4.15–11.34 4.15–11.34 NUM dti-1408 97 31 ) ) PUNCT dti-1408 97 32 and and CCONJ dti-1408 97 33 8.13 8.13 NUM dti-1408 97 34 ( ( PUNCT dti-1408 97 35 5.03–11.68 5.03–11.68 NUM dti-1408 97 36 ) ) PUNCT dti-1408 97 37 pmol pmol PROPN dti-1408 97 38 / / SYM dti-1408 97 39 l l NOUN dti-1408 97 40 , , PUNCT dti-1408 97 41 respectively respectively ADV dti-1408 97 42 , , PUNCT dti-1408 97 43 p p X dti-1408 97 44 = = PROPN dti-1408 97 45 0.461 0.461 NUM dti-1408 97 46 ] ] X dti-1408 97 47 , , PUNCT dti-1408 97 48 whether whether SCONJ dti-1408 97 49 they they PRON dti-1408 97 50 were be AUX dti-1408 97 51 treated treat VERB dti-1408 97 52 with with ADP dti-1408 97 53 anti anti ADJ dti-1408 97 54 - - ADJ dti-1408 97 55 inflammatory inflammatory ADJ dti-1408 97 56 drugs drug NOUN dti-1408 97 57 or or CCONJ dti-1408 97 58 not not PART dti-1408 97 59 [ [ X dti-1408 97 60 4.69 4.69 NUM dti-1408 97 61 ( ( PUNCT dti-1408 97 62 3.06–11.77 3.06–11.77 NUM dti-1408 97 63 ) ) PUNCT dti-1408 97 64 and and CCONJ dti-1408 97 65 8.09 8.09 NUM dti-1408 97 66 ( ( PUNCT dti-1408 97 67 5.60–11.43 5.60–11.43 NUM dti-1408 97 68 ) ) PUNCT dti-1408 97 69 pmol pmol PROPN dti-1408 97 70 / / SYM dti-1408 97 71 l l NOUN dti-1408 97 72 , , PUNCT dti-1408 97 73 respectively respectively ADV dti-1408 97 74 , , PUNCT dti-1408 97 75 p p X dti-1408 97 76 = = PROPN dti-1408 97 77 0.254 0.254 NUM dti-1408 97 78 ] ] PUNCT dti-1408 97 79 , , PUNCT dti-1408 97 80 or or CCONJ dti-1408 97 81 whether whether SCONJ dti-1408 97 82 they they PRON dti-1408 97 83 had have VERB dti-1408 97 84 a a DET dti-1408 97 85 limited limited ADJ dti-1408 97 86 or or CCONJ dti-1408 97 87 extensive extensive ADJ dti-1408 97 88 disease disease NOUN dti-1408 97 89 [ [ X dti-1408 97 90 8.03 8.03 NUM dti-1408 97 91 ( ( PUNCT dti-1408 97 92 5.53–12.60 5.53–12.60 NUM dti-1408 97 93 ) ) PUNCT dti-1408 97 94 and and CCONJ dti-1408 97 95 8.13 8.13 NUM dti-1408 97 96 ( ( PUNCT dti-1408 97 97 5.24–11.05 5.24–11.05 NUM dti-1408 97 98 ) ) PUNCT dti-1408 97 99 pmol pmol PROPN dti-1408 97 100 / / SYM dti-1408 97 101 l l NOUN dti-1408 97 102 , , PUNCT dti-1408 97 103 respectively respectively ADV dti-1408 97 104 , , PUNCT dti-1408 97 105 p p X dti-1408 97 106 = = PROPN dti-1408 97 107 0.493 0.493 NUM dti-1408 97 108 ] ] PUNCT dti-1408 97 109 . . PUNCT dti-1408 98 1 since since SCONJ dti-1408 98 2 age age NOUN dti-1408 98 3 and and CCONJ dti-1408 98 4 disease disease NOUN dti-1408 98 5 duration duration NOUN dti-1408 98 6 were be AUX dti-1408 98 7 strongly strongly ADV dti-1408 98 8 correlated correlate VERB dti-1408 98 9 ( ( PUNCT dti-1408 98 10 rs rs NOUN dti-1408 98 11 = = SYM dti-1408 98 12 0.374 0.374 NUM dti-1408 98 13 , , PUNCT dti-1408 98 14 p p X dti-1408 98 15 = = NOUN dti-1408 98 16 0.003 0.003 NUM dti-1408 98 17 ) ) PUNCT dti-1408 98 18 , , PUNCT dti-1408 98 19 the the DET dti-1408 98 20 correlation correlation NOUN dti-1408 98 21 between between ADP dti-1408 98 22 disease disease NOUN dti-1408 98 23 duration duration NOUN dti-1408 98 24 and and CCONJ dti-1408 98 25 plasma plasma NOUN dti-1408 98 26 levels level NOUN dti-1408 98 27 of of ADP dti-1408 98 28 mr mr PROPN dti-1408 98 29 - - PUNCT dti-1408 98 30 proadm proadm PROPN dti-1408 98 31 ( ( PUNCT dti-1408 98 32 rs rs NOUN dti-1408 98 33 = = PUNCT dti-1408 98 34 0.380 0.380 NUM dti-1408 98 35 , , PUNCT dti-1408 98 36 p p X dti-1408 98 37 = = NOUN dti-1408 98 38 0.005 0.005 NUM dti-1408 98 39 ) ) PUNCT dti-1408 98 40 , , PUNCT dti-1408 98 41 nt not PART dti-1408 98 42 - - PUNCT dti-1408 98 43 pta pta INTJ dti-1408 98 44 ( ( PUNCT dti-1408 98 45 rs rs NOUN dti-1408 98 46 = = SYM dti-1408 98 47 0.483 0.483 NUM dti-1408 98 48 , , PUNCT dti-1408 98 49 p p NOUN dti-1408 98 50 = = NOUN dti-1408 98 51 0.001 0.001 NUM dti-1408 98 52 ) ) PUNCT dti-1408 98 53 , , PUNCT dti-1408 98 54 and and CCONJ dti-1408 98 55 mr mr PROPN dti-1408 98 56 - - PUNCT dti-1408 98 57 penk penk PROPN dti-1408 98 58 a a X dti-1408 98 59 ( ( PUNCT dti-1408 98 60 rs rs NOUN dti-1408 98 61 = = SYM dti-1408 98 62 0.302 0.302 NUM dti-1408 98 63 , , PUNCT dti-1408 98 64 p p X dti-1408 98 65 = = NOUN dti-1408 98 66 0.037 0.037 NUM dti-1408 98 67 ) ) PUNCT dti-1408 98 68 was be AUX dti-1408 98 69 reflected reflect VERB dti-1408 98 70 by by ADP dti-1408 98 71 concomitant concomitant ADJ dti-1408 98 72 correlation correlation NOUN dti-1408 98 73 with with ADP dti-1408 98 74 age age NOUN dti-1408 98 75 ( ( PUNCT dti-1408 98 76 rs rs NOUN dti-1408 98 77 = = PUNCT dti-1408 98 78 0.668 0.668 NUM dti-1408 98 79 , , PUNCT dti-1408 98 80 p p NOUN dti-1408 98 81   PROPN dti-1408 98 82 0.0001 0.0001 NUM dti-1408 98 83 ; ; PUNCT dti-1408 98 84 rs rs NOUN dti-1408 98 85 = = SYM dti-1408 98 86 0.483 0.483 NUM dti-1408 98 87 , , PUNCT dti-1408 98 88 p p NOUN dti-1408 98 89   PROPN dti-1408 98 90 0.0001 0.0001 NUM dti-1408 98 91 ; ; PUNCT dti-1408 98 92 and and CCONJ dti-1408 98 93 rs r NOUN dti-1408 98 94     SPACE dti-1408 98 95 = = NOUN dti-1408 98 96     SPACE dti-1408 98 97 0.315 0.315 NUM dti-1408 98 98 , , PUNCT dti-1408 98 99 p p X dti-1408 98 100 = = NOUN dti-1408 98 101 0.026 0.026 NUM dti-1408 98 102 , , PUNCT dti-1408 98 103 respectively respectively ADV dti-1408 98 104 ) ) PUNCT dti-1408 98 105 . . PUNCT dti-1408 99 1 the the DET dti-1408 99 2 expression expression NOUN dti-1408 99 3 of of ADP dti-1408 99 4 crohn crohn PROPN dti-1408 99 5 ’s ’s PART dti-1408 99 6 disease disease NOUN dti-1408 99 7 or or CCONJ dti-1408 99 8 ulcerative ulcerative ADJ dti-1408 99 9 colitis colitis NOUN dti-1408 99 10 , , PUNCT dti-1408 99 11 treatment treatment NOUN dti-1408 99 12 with with ADP dti-1408 99 13 anti anti ADJ dti-1408 99 14 - - ADJ dti-1408 99 15 inflammatory inflammatory ADJ dti-1408 99 16 drugs drug NOUN dti-1408 99 17 or or CCONJ dti-1408 99 18 not not PART dti-1408 99 19 , , PUNCT dti-1408 99 20 limited limited ADJ dti-1408 99 21 or or CCONJ dti-1408 99 22 extensive extensive ADJ dti-1408 99 23 disease disease NOUN dti-1408 99 24 , , PUNCT dti-1408 99 25 or or CCONJ dti-1408 99 26 a a DET dti-1408 99 27 past past ADJ dti-1408 99 28 bowel bowel NOUN dti-1408 99 29 resection resection NOUN dti-1408 99 30 did do AUX dti-1408 99 31 not not PART dti-1408 99 32 affect affect VERB dti-1408 99 33 the the DET dti-1408 99 34 plasma plasma NOUN dti-1408 99 35 levels level NOUN dti-1408 99 36 of of ADP dti-1408 99 37 any any PRON dti-1408 99 38 of of ADP dti-1408 99 39 the the DET dti-1408 99 40 other other ADJ dti-1408 99 41 precursors precursor NOUN dti-1408 99 42 ( ( PUNCT dti-1408 99 43 data datum NOUN dti-1408 99 44 not not PART dti-1408 99 45 shown show VERB dti-1408 99 46 ) ) PUNCT dti-1408 99 47 . . PUNCT dti-1408 100 1 when when SCONJ dti-1408 100 2 calculated calculate VERB dti-1408 100 3 separately separately ADV dti-1408 100 4 , , PUNCT dti-1408 100 5 there there PRON dti-1408 100 6 was be VERB dti-1408 100 7 a a DET dti-1408 100 8 difference difference NOUN dti-1408 100 9 between between ADP dti-1408 100 10 mpm mpm NOUN dti-1408 100 11 and and CCONJ dti-1408 100 12 controls control NOUN dti-1408 100 13 regarding regard VERB dti-1408 100 14 plasma plasma NOUN dti-1408 100 15 levels level NOUN dti-1408 100 16 of of ADP dti-1408 100 17 copeptin copeptin PROPN dti-1408 100 18 and and CCONJ dti-1408 100 19 mr mr PROPN dti-1408 100 20 - - PUNCT dti-1408 100 21 proadm proadm PROPN dti-1408 100 22 but but CCONJ dti-1408 100 23 not not PART dti-1408 100 24 regarding regard VERB dti-1408 100 25 those those PRON dti-1408 100 26 of of ADP dti-1408 100 27 the the DET dti-1408 100 28 other other ADJ dti-1408 100 29 precursors precursor NOUN dti-1408 100 30 ( ( PUNCT dti-1408 100 31 table table NOUN dti-1408 100 32 3 3 NUM dti-1408 100 33 ) ) PUNCT dti-1408 100 34 . . PUNCT dti-1408 101 1 the the DET dti-1408 101 2 level level NOUN dti-1408 101 3 of of ADP dti-1408 101 4 copeptin copeptin NOUN dti-1408 101 5 was be AUX dti-1408 101 6 higher high ADJ dti-1408 101 7 in in ADP dti-1408 101 8 patients patient NOUN dti-1408 101 9 who who PRON dti-1408 101 10 had have AUX dti-1408 101 11 undergone undergo VERB dti-1408 101 12 a a DET dti-1408 101 13 bowel bowel NOUN dti-1408 101 14 resection resection NOUN dti-1408 101 15 ( ( PUNCT dti-1408 101 16 n n NOUN dti-1408 101 17 = = NUM dti-1408 101 18 12 12 NUM dti-1408 101 19 ) ) PUNCT dti-1408 101 20 compared compare VERB dti-1408 101 21 with with ADP dti-1408 101 22 the the DET dti-1408 101 23 nonresected nonresected ADJ dti-1408 101 24 ( ( PUNCT dti-1408 101 25 n n NOUN dti-1408 101 26 = = SYM dti-1408 101 27 6 6 NUM dti-1408 101 28 , , PUNCT dti-1408 101 29 missing miss VERB dti-1408 101 30 value value NOUN dti-1408 101 31 = = NOUN dti-1408 101 32 4 4 NUM dti-1408 101 33 ) ) PUNCT dti-1408 101 34 , , PUNCT dti-1408 101 35 although although SCONJ dti-1408 101 36 it it PRON dti-1408 101 37 did do AUX dti-1408 101 38 not not PART dti-1408 101 39 reach reach VERB dti-1408 101 40 statistical statistical ADJ dti-1408 101 41 significance significance NOUN dti-1408 101 42 in in ADP dti-1408 101 43 the the DET dti-1408 101 44 small small ADJ dti-1408 101 45 cohort cohort NOUN dti-1408 102 1 [ [ X dti-1408 102 2 11.46 11.46 NUM dti-1408 102 3 ( ( PUNCT dti-1408 102 4 8.33–19.08 8.33–19.08 NUM dti-1408 102 5 ) ) PUNCT dti-1408 102 6 and and CCONJ dti-1408 102 7 7.42 7.42 NUM dti-1408 102 8 ( ( PUNCT dti-1408 102 9 5.68–14.44 5.68–14.44 NUM dti-1408 102 10 ) ) PUNCT dti-1408 102 11 , , PUNCT dti-1408 102 12 respectively respectively ADV dti-1408 102 13 , , PUNCT dti-1408 102 14 p p X dti-1408 102 15 = = PROPN dti-1408 102 16 0.291 0.291 NUM dti-1408 102 17 ] ] PUNCT dti-1408 102 18 . . PUNCT dti-1408 103 1 neither neither CCONJ dti-1408 103 2 was be AUX dti-1408 103 3 there there PRON dti-1408 103 4 any any DET dti-1408 103 5 difference difference NOUN dti-1408 103 6 in in ADP dti-1408 103 7 plasma plasma NOUN dti-1408 103 8 copeptin copeptin NOUN dti-1408 103 9 levels level NOUN dti-1408 103 10 depending depend VERB dti-1408 103 11 on on ADP dti-1408 103 12 crohn crohn PROPN dti-1408 103 13 ’s ’s PART dti-1408 103 14 disease disease NOUN dti-1408 103 15 or or CCONJ dti-1408 103 16 ulcerative ulcerative ADJ dti-1408 103 17 colitis colitis NOUN dti-1408 104 1 [ [ X dti-1408 104 2 7.92 7.92 NUM dti-1408 104 3 ( ( PUNCT dti-1408 104 4 5.68–11.01 5.68–11.01 NUM dti-1408 104 5 ) ) PUNCT dti-1408 104 6 and and CCONJ dti-1408 104 7 10.41 10.41 NUM dti-1408 104 8 ( ( PUNCT dti-1408 104 9 5.92–16.68 5.92–16.68 NUM dti-1408 104 10 ) ) PUNCT dti-1408 104 11 , , PUNCT dti-1408 104 12 respectively respectively ADV dti-1408 104 13 , , PUNCT dti-1408 104 14 p p X dti-1408 104 15 = = NOUN dti-1408 104 16 0.365 0.365 NUM dti-1408 104 17 ] ] PUNCT dti-1408 104 18 , , PUNCT dti-1408 104 19 were be AUX dti-1408 104 20 treated treat VERB dti-1408 104 21 with with ADP dti-1408 104 22 anti anti ADJ dti-1408 104 23 - - ADJ dti-1408 104 24 inflammatory inflammatory ADJ dti-1408 104 25 drugs drug NOUN dti-1408 104 26 or or CCONJ dti-1408 104 27 not not PART dti-1408 104 28 [ [ X dti-1408 104 29 9.71 9.71 NUM dti-1408 104 30 ( ( PUNCT dti-1408 104 31 3.90–12.81 3.90–12.81 NUM dti-1408 104 32 ) ) PUNCT dti-1408 104 33 and and CCONJ dti-1408 104 34 8.66 8.66 NUM dti-1408 104 35 [ [ X dti-1408 104 36 6.09–18.16 6.09–18.16 X dti-1408 104 37 ] ] X dti-1408 104 38 pmol pmol PROPN dti-1408 104 39 / / SYM dti-1408 104 40 l l NOUN dti-1408 104 41 , , PUNCT dti-1408 104 42 respectively respectively ADV dti-1408 104 43 , , PUNCT dti-1408 104 44 p p X dti-1408 104 45 = = NOUN dti-1408 104 46 0.693 0.693 NUM dti-1408 104 47 ) ) PUNCT dti-1408 104 48 or or CCONJ dti-1408 104 49 a a DET dti-1408 104 50 limited limited ADJ dti-1408 104 51 or or CCONJ dti-1408 104 52 extensive extensive ADJ dti-1408 104 53 disease disease NOUN dti-1408 104 54 [ [ X dti-1408 104 55 11.75 11.75 NUM dti-1408 104 56 ( ( PUNCT dti-1408 104 57 7.08–17.86 7.08–17.86 NOUN dti-1408 104 58 ) ) PUNCT dti-1408 104 59 and and CCONJ dti-1408 104 60 9.01 9.01 NUM dti-1408 104 61 ( ( PUNCT dti-1408 104 62 5.90–13.82 5.90–13.82 NUM dti-1408 104 63 ) ) PUNCT dti-1408 104 64 , , PUNCT dti-1408 104 65 respectively respectively ADV dti-1408 104 66 , , PUNCT dti-1408 104 67 p p X dti-1408 104 68 = = PROPN dti-1408 104 69 0.604 0.604 NUM dti-1408 104 70 ] ] PUNCT dti-1408 104 71 . . PUNCT dti-1408 105 1 regarding regard VERB dti-1408 105 2 mr mr PROPN dti-1408 105 3 - - PUNCT dti-1408 105 4 proadm proadm PROPN dti-1408 105 5 , , PUNCT dti-1408 105 6 there there PRON dti-1408 105 7 was be VERB dti-1408 105 8 no no DET dti-1408 105 9 difference difference NOUN dti-1408 105 10 in in ADP dti-1408 105 11 plasma plasma NOUN dti-1408 105 12 levels level NOUN dti-1408 105 13 depending depend VERB dti-1408 105 14 on on ADP dti-1408 105 15 bowel bowel NOUN dti-1408 105 16 resection resection NOUN dti-1408 105 17 or or CCONJ dti-1408 105 18 not not PART dti-1408 105 19 [ [ X dti-1408 105 20 0.83 0.83 NUM dti-1408 105 21 ( ( PUNCT dti-1408 105 22 0.65–1.22 0.65–1.22 NUM dti-1408 105 23 ) ) PUNCT dti-1408 105 24 and and CCONJ dti-1408 105 25 0.84 0.84 NUM dti-1408 105 26 ( ( PUNCT dti-1408 105 27 0.73–1.05 0.73–1.05 NOUN dti-1408 105 28 ) ) PUNCT dti-1408 105 29 , , PUNCT dti-1408 105 30 respectively respectively ADV dti-1408 105 31 , , PUNCT dti-1408 105 32 p p X dti-1408 105 33 = = NOUN dti-1408 105 34 0.892 0.892 NUM dti-1408 105 35 ] ] PUNCT dti-1408 105 36 , , PUNCT dti-1408 105 37 crohn crohn PROPN dti-1408 105 38 ’s ’s PART dti-1408 105 39 disease disease NOUN dti-1408 105 40 or or CCONJ dti-1408 105 41 ulcerative ulcerative ADJ dti-1408 105 42 colitis colitis NOUN dti-1408 105 43 [ [ X dti-1408 105 44 0.75 0.75 NUM dti-1408 105 45 ( ( PUNCT dti-1408 105 46 0.69–0.87 0.69–0.87 NUM dti-1408 105 47 ) ) PUNCT dti-1408 105 48 and and CCONJ dti-1408 105 49 0.86 0.86 NUM dti-1408 105 50 ( ( PUNCT dti-1408 105 51 0.66–1.11 0.66–1.11 NOUN dti-1408 105 52 ) ) PUNCT dti-1408 105 53 , , PUNCT dti-1408 105 54 respectively respectively ADV dti-1408 105 55 , , PUNCT dti-1408 105 56 p p X dti-1408 105 57 = = SYM dti-1408 105 58 0525 0525 NUM dti-1408 105 59 ] ] PUNCT dti-1408 105 60 , , PUNCT dti-1408 105 61 were be AUX dti-1408 105 62 treated treat VERB dti-1408 105 63 with with ADP dti-1408 105 64 anti anti ADJ dti-1408 105 65 - - ADJ dti-1408 105 66 inflammatory inflammatory ADJ dti-1408 105 67 drugs drug NOUN dti-1408 105 68 or or CCONJ dti-1408 105 69 not not PART dti-1408 106 1 [ [ X dti-1408 106 2 0.84 0.84 NUM dti-1408 106 3 ( ( PUNCT dti-1408 106 4 0.67–1.11 0.67–1.11 NUM dti-1408 106 5 ) ) PUNCT dti-1408 106 6 and and CCONJ dti-1408 106 7 0.79 0.79 NUM dti-1408 106 8 ( ( PUNCT dti-1408 106 9 0.68–1.01 0.68–1.01 PROPN dti-1408 106 10 ) ) PUNCT dti-1408 106 11 pmol pmol PROPN dti-1408 106 12 / / SYM dti-1408 106 13 l l NOUN dti-1408 106 14 , , PUNCT dti-1408 106 15 respectively respectively ADV dti-1408 106 16 , , PUNCT dti-1408 106 17 p p X dti-1408 106 18 = = NOUN dti-1408 106 19 0.858 0.858 NUM dti-1408 106 20 ] ] PUNCT dti-1408 106 21 , , PUNCT dti-1408 106 22 or or CCONJ dti-1408 106 23 a a DET dti-1408 106 24 limited limited ADJ dti-1408 106 25 or or CCONJ dti-1408 106 26 extensive extensive ADJ dti-1408 106 27 disease disease NOUN dti-1408 106 28 [ [ X dti-1408 106 29 0.89 0.89 NUM dti-1408 106 30 ( ( PUNCT dti-1408 106 31 0.75–1.37 0.75–1.37 NUM dti-1408 106 32 ) ) PUNCT dti-1408 106 33 and and CCONJ dti-1408 106 34 0.77 0.77 NUM dti-1408 106 35 ( ( PUNCT dti-1408 106 36 0.64–1.04 0.64–1.04 NUM dti-1408 106 37 ) ) PUNCT dti-1408 106 38 , , PUNCT dti-1408 106 39 respectively respectively ADV dti-1408 106 40 , , PUNCT dti-1408 106 41 p p X dti-1408 106 42 = = NOUN dti-1408 106 43 0.182 0.182 NUM dti-1408 106 44 ] ] PUNCT dti-1408 106 45 . . PUNCT dti-1408 107 1 in in ADP dti-1408 107 2 the the DET dti-1408 107 3 mdc mdc NOUN dti-1408 107 4 - - PUNCT dti-1408 107 5 cc cc NOUN dti-1408 107 6 cohort cohort NOUN dti-1408 107 7 , , PUNCT dti-1408 107 8 no no DET dti-1408 107 9 differences difference NOUN dti-1408 107 10 were be AUX dti-1408 107 11 seen see VERB dti-1408 107 12 between between ADP dti-1408 107 13 controls control NOUN dti-1408 107 14 and and CCONJ dti-1408 107 15 patients patient NOUN dti-1408 107 16 in in ADP dti-1408 107 17 any any DET dti-1408 107 18 plasma plasma NOUN dti-1408 107 19 precursor precursor NOUN dti-1408 107 20 analyses analysis NOUN dti-1408 107 21 ( ( PUNCT dti-1408 107 22 table table NOUN dti-1408 107 23 4 4 NUM dti-1408 107 24 ) ) PUNCT dti-1408 107 25 . . PUNCT dti-1408 108 1 neither neither PRON dti-1408 108 2 were be VERB dti-1408 108 3 any any DET dti-1408 108 4 differences difference NOUN dti-1408 108 5 in in ADP dti-1408 108 6 plasma plasma NOUN dti-1408 108 7 levels level NOUN dti-1408 108 8 of of ADP dti-1408 108 9 any any PRON dti-1408 108 10 of of ADP dti-1408 108 11 the the DET dti-1408 108 12 precursors precursor NOUN dti-1408 108 13 between between ADP dti-1408 108 14 the the DET dti-1408 108 15 expression expression NOUN dti-1408 108 16 of of ADP dti-1408 108 17 crohn crohn PROPN dti-1408 108 18 ’s ’s PART dti-1408 108 19 disease disease NOUN dti-1408 108 20 or or CCONJ dti-1408 108 21 ulcerative ulcerative ADJ dti-1408 108 22 colitis colitis NOUN dti-1408 108 23 , , PUNCT dti-1408 108 24 treatment treatment NOUN dti-1408 108 25 with with ADP dti-1408 108 26 anti anti ADJ dti-1408 108 27 - - ADJ dti-1408 108 28 inflammatory inflammatory ADJ dti-1408 108 29 drugs drug NOUN dti-1408 108 30 or or CCONJ dti-1408 108 31 not not PART dti-1408 108 32 , , PUNCT dti-1408 108 33 limited limited ADJ dti-1408 108 34 or or CCONJ dti-1408 108 35 extensive extensive ADJ dti-1408 108 36 disease disease NOUN dti-1408 108 37 , , PUNCT dti-1408 108 38 or or CCONJ dti-1408 108 39 a a DET dti-1408 108 40 past past ADJ dti-1408 108 41 bowel bowel NOUN dti-1408 108 42 resection resection NOUN dti-1408 108 43 ( ( PUNCT dti-1408 108 44 data datum NOUN dti-1408 108 45 not not PART dti-1408 108 46 shown show VERB dti-1408 108 47 ) ) PUNCT dti-1408 108 48 . . PUNCT dti-1408 109 1 discussion discussion NOUN dti-1408 109 2 the the DET dti-1408 109 3 main main ADJ dti-1408 109 4 conclusion conclusion NOUN dti-1408 109 5 of of ADP dti-1408 109 6 this this DET dti-1408 109 7 study study NOUN dti-1408 109 8 is be AUX dti-1408 109 9 that that SCONJ dti-1408 109 10 basal basal ADJ dti-1408 109 11 plasma plasma NOUN dti-1408 109 12 copeptin copeptin NOUN dti-1408 109 13 levels level NOUN dti-1408 109 14 are be AUX dti-1408 109 15 elevated elevate VERB dti-1408 109 16 after after ADP dti-1408 109 17 complete complete ADJ dti-1408 109 18 bowel bowel NOUN dti-1408 109 19 resection resection NOUN dti-1408 109 20 , , PUNCT dti-1408 109 21 but but CCONJ dti-1408 109 22 other other ADJ dti-1408 109 23 peptide peptide NOUN dti-1408 109 24 precursors precursor NOUN dti-1408 109 25 are be AUX dti-1408 109 26 unaffected unaffected ADJ dti-1408 109 27 in in ADP dti-1408 109 28 middle middle ADJ dti-1408 109 29 - - PUNCT dti-1408 109 30 aged aged ADJ dti-1408 109 31 subjects subject NOUN dti-1408 109 32 in in ADP dti-1408 109 33 inactive inactive ADJ dti-1408 109 34 ibd ibd NOUN dti-1408 109 35 compared compare VERB dti-1408 109 36 with with ADP dti-1408 109 37 matched match VERB dti-1408 109 38 controls control NOUN dti-1408 109 39 . . PUNCT dti-1408 110 1 however however ADV dti-1408 110 2 , , PUNCT dti-1408 110 3 the the DET dti-1408 110 4 elevated elevated ADJ dti-1408 110 5 copeptin copeptin NOUN dti-1408 110 6 levels level NOUN dti-1408 110 7 did do AUX dti-1408 110 8 not not PART dti-1408 110 9 reach reach VERB dti-1408 110 10 statistical statistical ADJ dti-1408 110 11 significance significance NOUN dti-1408 110 12 when when SCONJ dti-1408 110 13 precursor precursor NOUN dti-1408 110 14 levels level NOUN dti-1408 110 15 were be AUX dti-1408 110 16 calculated calculate VERB dti-1408 110 17 separately separately ADV dti-1408 110 18 in in ADP dti-1408 110 19 the the DET dti-1408 110 20 mdccc mdccc PROPN dti-1408 110 21 cohort cohort NOUN dti-1408 110 22 , , PUNCT dti-1408 110 23 or or CCONJ dti-1408 110 24 when when SCONJ dti-1408 110 25 the the DET dti-1408 110 26 mpm mpm NOUN dti-1408 110 27 cohort cohort NOUN dti-1408 110 28 was be AUX dti-1408 110 29 separated separate VERB dti-1408 110 30 into into ADP dti-1408 110 31 table table NOUN dti-1408 110 32 2 2 NUM dti-1408 110 33 . . PUNCT dti-1408 110 34 plasma plasma NOUN dti-1408 110 35 peptide peptide NOUN dti-1408 110 36 levels level NOUN dti-1408 110 37 from from ADP dti-1408 110 38 all all DET dti-1408 110 39 patients patient NOUN dti-1408 110 40 with with ADP dti-1408 110 41 inflammatory inflammatory ADJ dti-1408 110 42 bowel bowel NOUN dti-1408 110 43 disease disease NOUN dti-1408 110 44 and and CCONJ dti-1408 110 45 controls control NOUN dti-1408 110 46 . . PUNCT dti-1408 111 1 ibd ibd PROPN dti-1408 111 2 ( ( PUNCT dti-1408 111 3 n n NOUN dti-1408 111 4 = = SYM dti-1408 111 5 62 62 NUM dti-1408 111 6 ) ) PUNCT dti-1408 111 7 controls control NOUN dti-1408 111 8 ( ( PUNCT dti-1408 111 9 n n NOUN dti-1408 111 10 = = SYM dti-1408 111 11 186 186 NUM dti-1408 111 12 ) ) PUNCT dti-1408 111 13 p p ADJ dti-1408 111 14 - - PUNCT dti-1408 111 15 value value NOUN dti-1408 111 16 copeptin copeptin NOUN dti-1408 111 17 ( ( PUNCT dti-1408 111 18 pmol pmol X dti-1408 111 19 / / SYM dti-1408 111 20 l l NOUN dti-1408 111 21 ) ) PUNCT dti-1408 111 22 8.0 8.0 NUM dti-1408 111 23 ( ( PUNCT dti-1408 111 24 4.8–11.5 4.8–11.5 NOUN dti-1408 111 25 ) ) PUNCT dti-1408 111 26 ( ( PUNCT dti-1408 111 27 56 56 NUM dti-1408 111 28 ) ) PUNCT dti-1408 111 29 5.8 5.8 NUM dti-1408 111 30 ( ( PUNCT dti-1408 111 31 3.4–8.5 3.4–8.5 NUM dti-1408 111 32 ) ) PUNCT dti-1408 111 33 ( ( PUNCT dti-1408 111 34 181 181 NUM dti-1408 111 35 ) ) PUNCT dti-1408 111 36 0.006 0.006 NUM dti-1408 111 37 mr mr PROPN dti-1408 111 38 - - PUNCT dti-1408 111 39 proadm proadm PROPN dti-1408 111 40 ( ( PUNCT dti-1408 111 41 nmol nmol NOUN dti-1408 111 42 / / SYM dti-1408 111 43 l l NOUN dti-1408 111 44 ) ) PUNCT dti-1408 111 45 0.6 0.6 NUM dti-1408 111 46 ( ( PUNCT dti-1408 111 47 0.4–0.8 0.4–0.8 ADV dti-1408 111 48 ) ) PUNCT dti-1408 111 49 ( ( PUNCT dti-1408 111 50 56 56 NUM dti-1408 111 51 ) ) PUNCT dti-1408 111 52 0.5 0.5 NUM dti-1408 111 53 ( ( PUNCT dti-1408 111 54 0.4–0.7 0.4–0.7 NUM dti-1408 111 55 ) ) PUNCT dti-1408 111 56 ( ( PUNCT dti-1408 111 57 182 182 NUM dti-1408 111 58 ) ) PUNCT dti-1408 111 59 0.127 0.127 NUM dti-1408 111 60 mr mr PROPN dti-1408 111 61 - - PUNCT dti-1408 111 62 proanp proanp PROPN dti-1408 111 63 ( ( PUNCT dti-1408 111 64 pmol pmol PROPN dti-1408 111 65 / / SYM dti-1408 111 66 l l NOUN dti-1408 111 67 ) ) PUNCT dti-1408 111 68 78.0 78.0 NUM dti-1408 111 69 ( ( PUNCT dti-1408 111 70 59.2–111.8 59.2–111.8 NUM dti-1408 111 71 ) ) PUNCT dti-1408 111 72 ( ( PUNCT dti-1408 111 73 56 56 NUM dti-1408 111 74 ) ) PUNCT dti-1408 111 75 72.7 72.7 NUM dti-1408 111 76 ( ( PUNCT dti-1408 111 77 54.1–101.3 54.1–101.3 NUM dti-1408 111 78 ) ) PUNCT dti-1408 111 79 ( ( PUNCT dti-1408 111 80 182 182 NUM dti-1408 111 81 ) ) PUNCT dti-1408 111 82 0.367 0.367 NUM dti-1408 111 83 notes note VERB dti-1408 111 84 : : PUNCT dti-1408 111 85 n n NOUN dti-1408 111 86 = = NOUN dti-1408 111 87 number number NOUN dti-1408 111 88 of of ADP dti-1408 111 89 analyses analysis NOUN dti-1408 111 90 . . PUNCT dti-1408 112 1 values value NOUN dti-1408 112 2 are be AUX dti-1408 112 3 given give VERB dti-1408 112 4 as as ADP dti-1408 112 5 median median PROPN dti-1408 112 6 [ [ X dti-1408 112 7 interquartile interquartile ADJ dti-1408 112 8 range range NOUN dti-1408 112 9 ( ( PUNCT dti-1408 112 10 iqr iqr NOUN dti-1408 112 11 ) ) PUNCT dti-1408 112 12 ] ] PUNCT dti-1408 112 13 . . PUNCT dti-1408 113 1 mann mann PROPN dti-1408 113 2 – – PUNCT dti-1408 113 3 whitney whitney PROPN dti-1408 113 4 u u NOUN dti-1408 113 5 - - NOUN dti-1408 113 6 test test NOUN dti-1408 113 7 . . PUNCT dti-1408 114 1 p p X dti-1408 114 2   NOUN dti-1408 114 3 0.05 0.05 NUM dti-1408 114 4 was be AUX dti-1408 114 5 considered consider VERB dti-1408 114 6 statistically statistically ADV dti-1408 114 7 significant significant ADJ dti-1408 114 8 . . PUNCT dti-1408 115 1 abbreviations abbreviation NOUN dti-1408 115 2 : : PUNCT dti-1408 115 3 ibd ibd NOUN dti-1408 115 4 , , PUNCT dti-1408 115 5 inflammatory inflammatory ADJ dti-1408 115 6 bowel bowel NOUN dti-1408 115 7 disease disease NOUN dti-1408 115 8 ; ; PUNCT dti-1408 115 9 mr mr PROPN dti-1408 115 10 - - PUNCT dti-1408 115 11 proadm proadm ADJ dti-1408 115 12 , , PUNCT dti-1408 115 13 midregional midregional ADJ dti-1408 115 14 fragment fragment NOUN dti-1408 115 15 of of ADP dti-1408 115 16 pro pro ADJ dti-1408 115 17 - - ADJ dti-1408 115 18 adrenomedullin adrenomedullin NOUN dti-1408 115 19 ; ; PUNCT dti-1408 115 20 mr mr PROPN dti-1408 115 21 - - PUNCT dti-1408 115 22 proanp proanp PROPN dti-1408 115 23 , , PUNCT dti-1408 115 24 midregional midregional ADJ dti-1408 115 25 fragment fragment NOUN dti-1408 115 26 of of ADP dti-1408 115 27 pro pro ADJ dti-1408 115 28 - - ADJ dti-1408 115 29 atrial atrial ADJ dti-1408 115 30 natriuretic natriuretic ADJ dti-1408 115 31 peptide peptide NOUN dti-1408 115 32 . . PUNCT dti-1408 116 1 table table NOUN dti-1408 116 2 3 3 NUM dti-1408 116 3 . . PUNCT dti-1408 116 4 plasma plasma NOUN dti-1408 116 5 peptide peptide NOUN dti-1408 116 6 levels level NOUN dti-1408 116 7 from from ADP dti-1408 116 8 patients patient NOUN dti-1408 116 9 in in ADP dti-1408 116 10 malmö malmö PROPN dti-1408 116 11 preventive preventive ADJ dti-1408 116 12 medicine medicine NOUN dti-1408 116 13 ( ( PUNCT dti-1408 116 14 mpm mpm NOUN dti-1408 116 15 ) ) PUNCT dti-1408 116 16 compared compare VERB dti-1408 116 17 with with ADP dti-1408 116 18 controls control NOUN dti-1408 116 19 . . PUNCT dti-1408 117 1 mpm mpm NOUN dti-1408 117 2 ( ( PUNCT dti-1408 117 3 n n NOUN dti-1408 117 4 = = SYM dti-1408 117 5 22 22 NUM dti-1408 117 6 ) ) PUNCT dti-1408 117 7 controls control NOUN dti-1408 117 8 ( ( PUNCT dti-1408 117 9 n n NOUN dti-1408 117 10 = = SYM dti-1408 117 11 66 66 NUM dti-1408 117 12 ) ) PUNCT dti-1408 117 13 p p X dti-1408 117 14 - - PUNCT dti-1408 117 15 value value NOUN dti-1408 117 16 copeptin copeptin NOUN dti-1408 117 17 ( ( PUNCT dti-1408 117 18 pmol pmol X dti-1408 117 19 / / SYM dti-1408 117 20 l l NOUN dti-1408 117 21 ) ) PUNCT dti-1408 117 22 8.66 8.66 NUM dti-1408 117 23 ( ( PUNCT dti-1408 117 24 5.90–12.81 5.90–12.81 NUM dti-1408 117 25 ) ) PUNCT dti-1408 117 26 6.23 6.23 NUM dti-1408 117 27 ( ( PUNCT dti-1408 117 28 3.79–9.19 3.79–9.19 NUM dti-1408 117 29 ) ) PUNCT dti-1408 117 30 0.007 0.007 NUM dti-1408 117 31 mr mr PROPN dti-1408 117 32 - - PUNCT dti-1408 117 33 proadm proadm PROPN dti-1408 117 34 ( ( PUNCT dti-1408 117 35 nmol nmol NOUN dti-1408 117 36 / / SYM dti-1408 117 37 l l NOUN dti-1408 117 38 ) ) PUNCT dti-1408 117 39 0.80 0.80 NUM dti-1408 117 40 ( ( PUNCT dti-1408 117 41 0.68–1.04 0.68–1.04 PROPN dti-1408 117 42 ) ) PUNCT dti-1408 117 43 0.70 0.70 NUM dti-1408 117 44 ( ( PUNCT dti-1408 117 45 0.57–0.84 0.57–0.84 NUM dti-1408 117 46 ) ) PUNCT dti-1408 117 47 0.010 0.010 NUM dti-1408 117 48 mr mr PROPN dti-1408 117 49 - - PUNCT dti-1408 117 50 proanp proanp PROPN dti-1408 117 51 ( ( PUNCT dti-1408 117 52 pmol pmol PROPN dti-1408 117 53 / / SYM dti-1408 117 54 l l NOUN dti-1408 117 55 ) ) PUNCT dti-1408 117 56 104.27 104.27 NUM dti-1408 117 57 ( ( PUNCT dti-1408 117 58 77.10–149.13 77.10–149.13 NUM dti-1408 117 59 ) ) PUNCT dti-1408 117 60 98.73 98.73 NUM dti-1408 117 61 ( ( PUNCT dti-1408 117 62 68.14–145.69 68.14–145.69 NOUN dti-1408 117 63 ) ) PUNCT dti-1408 117 64 0.649 0.649 NUM dti-1408 117 65 mr mr PROPN dti-1408 117 66 - - PUNCT dti-1408 117 67 penk penk PROPN dti-1408 117 68 ( ( PUNCT dti-1408 117 69 pmol pmol X dti-1408 117 70 / / SYM dti-1408 117 71 l l NOUN dti-1408 117 72 ) ) PUNCT dti-1408 117 73 59.48 59.48 NUM dti-1408 117 74 ( ( PUNCT dti-1408 117 75 54.41–74.41 54.41–74.41 NUM dti-1408 117 76 ) ) PUNCT dti-1408 117 77 60.89 60.89 NUM dti-1408 117 78 ( ( PUNCT dti-1408 117 79 50.39–74.63 50.39–74.63 NUM dti-1408 117 80 ) ) PUNCT dti-1408 117 81 0.785 0.785 NUM dti-1408 117 82 nt not PART dti-1408 117 83 - - PUNCT dti-1408 117 84 pta pta NOUN dti-1408 117 85 ( ( PUNCT dti-1408 117 86 pmol pmol X dti-1408 117 87 / / SYM dti-1408 117 88 l l NOUN dti-1408 117 89 ) ) PUNCT dti-1408 117 90 78.98 78.98 NUM dti-1408 117 91 ( ( PUNCT dti-1408 117 92 64.11–98.66 64.11–98.66 NUM dti-1408 117 93 ) ) PUNCT dti-1408 117 94 80.64 80.64 NUM dti-1408 117 95 ( ( PUNCT dti-1408 117 96 67.12–97.40 67.12–97.40 NUM dti-1408 117 97 ) ) PUNCT dti-1408 117 98 0.852 0.852 NUM dti-1408 117 99 proneurotensin proneurotensin NOUN dti-1408 117 100 ( ( PUNCT dti-1408 117 101 pmol pmol X dti-1408 117 102 / / SYM dti-1408 117 103 l l NOUN dti-1408 117 104 ) ) PUNCT dti-1408 117 105 79.15 79.15 NUM dti-1408 117 106 ( ( PUNCT dti-1408 117 107 63.15–130.45 63.15–130.45 NUM dti-1408 117 108 ) ) PUNCT dti-1408 117 109 84.45 84.45 NUM dti-1408 117 110 ( ( PUNCT dti-1408 117 111 62.18–119.65 62.18–119.65 NUM dti-1408 117 112 ) ) PUNCT dti-1408 117 113 0.972 0.972 NUM dti-1408 117 114 notes note VERB dti-1408 117 115 : : PUNCT dti-1408 117 116 n n NOUN dti-1408 117 117 = = NOUN dti-1408 117 118 number number NOUN dti-1408 117 119 of of ADP dti-1408 117 120 analyses analysis NOUN dti-1408 117 121 . . PUNCT dti-1408 118 1 values value NOUN dti-1408 118 2 are be AUX dti-1408 118 3 given give VERB dti-1408 118 4 as as ADP dti-1408 118 5 median median PROPN dti-1408 118 6 [ [ X dti-1408 118 7 interquartile interquartile ADJ dti-1408 118 8 range range NOUN dti-1408 118 9 ( ( PUNCT dti-1408 118 10 iqr iqr NOUN dti-1408 118 11 ) ) PUNCT dti-1408 118 12 ] ] PUNCT dti-1408 118 13 . . PUNCT dti-1408 119 1 mann mann PROPN dti-1408 119 2 – – PUNCT dti-1408 119 3 whitney whitney PROPN dti-1408 119 4 u u NOUN dti-1408 119 5 - - NOUN dti-1408 119 6 test test NOUN dti-1408 119 7 . . PUNCT dti-1408 120 1 p p X dti-1408 120 2   NOUN dti-1408 120 3 0.05 0.05 NUM dti-1408 120 4 was be AUX dti-1408 120 5 considered consider VERB dti-1408 120 6 statistically statistically ADV dti-1408 120 7 significant significant ADJ dti-1408 120 8 . . PUNCT dti-1408 121 1 abbreviations abbreviation NOUN dti-1408 121 2 : : PUNCT dti-1408 121 3 ibd ibd NOUN dti-1408 121 4 , , PUNCT dti-1408 121 5 inflammatory inflammatory ADJ dti-1408 121 6 bowel bowel NOUN dti-1408 121 7 disease disease NOUN dti-1408 121 8 ; ; PUNCT dti-1408 121 9 mr mr PROPN dti-1408 121 10 - - PUNCT dti-1408 121 11 proadm proadm ADJ dti-1408 121 12 , , PUNCT dti-1408 121 13 midregional midregional ADJ dti-1408 121 14 fragment fragment NOUN dti-1408 121 15 of of ADP dti-1408 121 16 pro pro ADJ dti-1408 121 17 - - ADJ dti-1408 121 18 adrenomedullin adrenomedullin NOUN dti-1408 121 19 ; ; PUNCT dti-1408 121 20 mr mr PROPN dti-1408 121 21 - - PUNCT dti-1408 121 22 proanp proanp PROPN dti-1408 121 23 , , PUNCT dti-1408 121 24 midregional midregional ADJ dti-1408 121 25 fragment fragment NOUN dti-1408 121 26 of of ADP dti-1408 121 27 pro pro ADJ dti-1408 121 28 - - ADJ dti-1408 121 29 atrial atrial ADJ dti-1408 121 30 natriuretic natriuretic ADJ dti-1408 121 31 peptide peptide NOUN dti-1408 121 32 ; ; PUNCT dti-1408 121 33 mr mr PROPN dti-1408 121 34 - - PUNCT dti-1408 121 35 penk penk PROPN dti-1408 121 36 , , PUNCT dti-1408 121 37 midregional midregional ADJ dti-1408 121 38 fragment fragment NOUN dti-1408 121 39 of of ADP dti-1408 121 40 proenkephalin proenkephalin PROPN dti-1408 121 41 a a PRON dti-1408 121 42 ; ; PUNCT dti-1408 121 43 nt not PART dti-1408 121 44 - - PUNCT dti-1408 121 45 pta pta NOUN dti-1408 121 46 , , PUNCT dti-1408 121 47 n n CCONJ dti-1408 121 48 - - PUNCT dti-1408 121 49 terminal terminal ADJ dti-1408 121 50 polytachykinin polytachykinin PROPN dti-1408 121 51 a. a. NOUN dti-1408 121 52 http://www.la-press.com http://www.la-press.com X dti-1408 121 53 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1408 121 54 basal basal ADJ dti-1408 121 55 plasma plasma NOUN dti-1408 121 56 levels level NOUN dti-1408 121 57 of of ADP dti-1408 121 58 copeptin copeptin NOUN dti-1408 121 59 in in ADP dti-1408 121 60 ibd ibd PROPN dti-1408 121 61 25drug 25drug PROPN dti-1408 121 62 target target PROPN dti-1408 121 63 insights insight NOUN dti-1408 121 64 2015:9 2015:9 NUM dti-1408 121 65 resected resect VERB dti-1408 121 66 and and CCONJ dti-1408 121 67 unresected unresected ADJ dti-1408 121 68 groups group NOUN dti-1408 121 69 . . PUNCT dti-1408 122 1 the the DET dti-1408 122 2 elevated elevated ADJ dti-1408 122 3 plasma plasma NOUN dti-1408 122 4 level level NOUN dti-1408 122 5 of of ADP dti-1408 122 6 mr mr PROPN dti-1408 122 7 - - PUNCT dti-1408 122 8 proadm proadm PROPN dti-1408 122 9 observed observe VERB dti-1408 122 10 in in ADP dti-1408 122 11 the the DET dti-1408 122 12 mpm mpm NOUN dti-1408 122 13 cohort cohort NOUN dti-1408 122 14 was be AUX dti-1408 122 15 diluted dilute VERB dti-1408 122 16 when when SCONJ dti-1408 122 17 the the DET dti-1408 122 18 two two NUM dti-1408 122 19 cohorts cohort NOUN dti-1408 122 20 were be AUX dti-1408 122 21 calculated calculate VERB dti-1408 122 22 together together ADV dti-1408 122 23 . . PUNCT dti-1408 123 1 the the DET dti-1408 123 2 etiology etiology NOUN dti-1408 123 3 of of ADP dti-1408 123 4 ibd ibd PROPN dti-1408 123 5 is be AUX dti-1408 123 6 unknown unknown ADJ dti-1408 123 7 , , PUNCT dti-1408 123 8 but but CCONJ dti-1408 123 9 a a DET dti-1408 123 10 complex complex ADJ dti-1408 123 11 interplay interplay NOUN dti-1408 123 12 of of ADP dti-1408 123 13 genetic genetic ADJ dti-1408 123 14 , , PUNCT dti-1408 123 15 microbial microbial ADJ dti-1408 123 16 , , PUNCT dti-1408 123 17 immunologic immunologic ADJ dti-1408 123 18 , , PUNCT dti-1408 123 19 and and CCONJ dti-1408 123 20 environmental environmental ADJ dti-1408 123 21 factors factor NOUN dti-1408 123 22 are be AUX dti-1408 123 23 discussed discuss VERB dti-1408 123 24 . . PUNCT dti-1408 124 1 the the DET dti-1408 124 2 inflammation inflammation NOUN dti-1408 124 3 in in ADP dti-1408 124 4 ibd ibd PROPN dti-1408 124 5 is be AUX dti-1408 124 6 mainly mainly ADV dti-1408 124 7 situated situate VERB dti-1408 124 8 in in ADP dti-1408 124 9 the the DET dti-1408 124 10 mucosa mucosa NOUN dti-1408 124 11 , , PUNCT dti-1408 124 12 but but CCONJ dti-1408 124 13 transmural transmural ADJ dti-1408 124 14 inflammation inflammation NOUN dti-1408 124 15 has have AUX dti-1408 124 16 been be AUX dti-1408 124 17 documented document VERB dti-1408 124 18 in in ADP dti-1408 124 19 both both DET dti-1408 124 20 crohn crohn PROPN dti-1408 124 21 ’s ’s PART dti-1408 124 22 disease disease NOUN dti-1408 124 23 and and CCONJ dti-1408 124 24 ulcerative ulcerative ADJ dti-1408 124 25 colitis.4 colitis.4 PROPN dti-1408 124 26 the the DET dti-1408 124 27 majority majority NOUN dti-1408 124 28 of of ADP dti-1408 124 29 the the DET dti-1408 124 30 neuropeptides neuropeptide NOUN dti-1408 124 31 are be AUX dti-1408 124 32 found find VERB dti-1408 124 33 both both PRON dti-1408 124 34 in in ADP dti-1408 124 35 the the DET dti-1408 124 36 central central ADJ dti-1408 124 37 nervous nervous ADJ dti-1408 124 38 system system NOUN dti-1408 124 39 ( ( PUNCT dti-1408 124 40 cns cns NOUN dti-1408 124 41 ) ) PUNCT dti-1408 124 42 and and CCONJ dti-1408 124 43 in in ADP dti-1408 124 44 the the DET dti-1408 124 45 ens en NOUN dti-1408 124 46 , , PUNCT dti-1408 124 47 and and CCONJ dti-1408 124 48 we we PRON dti-1408 124 49 do do AUX dti-1408 124 50 not not PART dti-1408 124 51 know know VERB dti-1408 124 52 whether whether SCONJ dti-1408 124 53 the the DET dti-1408 124 54 plasma plasma NOUN dti-1408 124 55 peptides peptide NOUN dti-1408 124 56 are be AUX dti-1408 124 57 of of ADP dti-1408 124 58 gastrointestinal gastrointestinal ADJ dti-1408 124 59 or or CCONJ dti-1408 124 60 cephalic cephalic ADJ dti-1408 124 61 origin origin NOUN dti-1408 124 62 . . PUNCT dti-1408 125 1 gastrointestinal gastrointestinal ADJ dti-1408 125 2 peptides peptide NOUN dti-1408 125 3 may may AUX dti-1408 125 4 be be AUX dti-1408 125 5 secreted secrete VERB dti-1408 125 6 from from ADP dti-1408 125 7 both both PRON dti-1408 125 8 enterochromaffin enterochromaffin NOUN dti-1408 125 9 mucosal mucosal NOUN dti-1408 125 10 cells cell NOUN dti-1408 125 11 and and CCONJ dti-1408 125 12 enteric enteric ADJ dti-1408 125 13 neurons.9,11,34 neurons.9,11,34 NOUN dti-1408 125 14 furthermore furthermore ADV dti-1408 125 15 , , PUNCT dti-1408 125 16 ibd ibd PROPN dti-1408 125 17 affects affect VERB dti-1408 125 18 the the DET dti-1408 125 19 brain brain NOUN dti-1408 125 20 – – PUNCT dti-1408 125 21 gut gut NOUN dti-1408 125 22 axis axis NOUN dti-1408 125 23 with with ADP dti-1408 125 24 possible possible ADJ dti-1408 125 25 subsequent subsequent ADJ dti-1408 125 26 effects effect NOUN dti-1408 125 27 on on ADP dti-1408 125 28 peptide peptide ADJ dti-1408 125 29 release release NOUN dti-1408 125 30 from from ADP dti-1408 125 31 the the DET dti-1408 125 32 brain.35 brain.35 NOUN dti-1408 125 33 the the DET dti-1408 125 34 modest modest ADJ dti-1408 125 35 effect effect NOUN dti-1408 125 36 on on ADP dti-1408 125 37 plasma plasma NOUN dti-1408 125 38 levels level NOUN dti-1408 125 39 of of ADP dti-1408 125 40 precursors precursor NOUN dti-1408 125 41 in in ADP dti-1408 125 42 the the DET dti-1408 125 43 present present ADJ dti-1408 125 44 study study NOUN dti-1408 125 45 suggests suggest VERB dti-1408 125 46 that that SCONJ dti-1408 125 47 , , PUNCT dti-1408 125 48 despite despite SCONJ dti-1408 125 49 the the DET dti-1408 125 50 chronic chronic ADJ dti-1408 125 51 nature nature NOUN dti-1408 125 52 of of ADP dti-1408 125 53 ibd ibd PROPN dti-1408 125 54 , , PUNCT dti-1408 125 55 the the DET dti-1408 125 56 disease disease NOUN dti-1408 125 57 does do AUX dti-1408 125 58 not not PART dti-1408 125 59 have have VERB dti-1408 125 60 a a DET dti-1408 125 61 major major ADJ dti-1408 125 62 impact impact NOUN dti-1408 125 63 on on ADP dti-1408 125 64 peptide peptide ADJ dti-1408 125 65 secretion secretion NOUN dti-1408 125 66 . . PUNCT dti-1408 126 1 nevertheless nevertheless ADV dti-1408 126 2 , , PUNCT dti-1408 126 3 as as SCONJ dti-1408 126 4 a a DET dti-1408 126 5 wide wide ADJ dti-1408 126 6 range range NOUN dti-1408 126 7 of of ADP dti-1408 126 8 neuropeptides neuropeptide NOUN dti-1408 126 9 and and CCONJ dti-1408 126 10 inflammatory inflammatory ADJ dti-1408 126 11 factors factor NOUN dti-1408 126 12 are be AUX dti-1408 126 13 involved involve VERB dti-1408 126 14 in in ADP dti-1408 126 15 physiological physiological ADJ dti-1408 126 16 and and CCONJ dti-1408 126 17 pathophysiological pathophysiological ADJ dti-1408 126 18 processes process NOUN dti-1408 126 19 , , PUNCT dti-1408 126 20 the the DET dti-1408 126 21 balance balance NOUN dti-1408 126 22 between between ADP dti-1408 126 23 peptides peptide NOUN dti-1408 126 24 , , PUNCT dti-1408 126 25 rather rather ADV dti-1408 126 26 than than ADP dti-1408 126 27 the the DET dti-1408 126 28 actual actual ADJ dti-1408 126 29 concentration concentration NOUN dti-1408 126 30 of of ADP dti-1408 126 31 one one NUM dti-1408 126 32 specific specific ADJ dti-1408 126 33 peptide peptide NOUN dti-1408 126 34 , , PUNCT dti-1408 126 35 may may AUX dti-1408 126 36 be be AUX dti-1408 126 37 important important ADJ dti-1408 126 38 . . PUNCT dti-1408 127 1 the the DET dti-1408 127 2 levels level NOUN dti-1408 127 3 of of ADP dti-1408 127 4 copeptin copeptin NOUN dti-1408 127 5 and and CCONJ dti-1408 127 6 vasopressin vasopressin NOUN dti-1408 127 7 in in ADP dti-1408 127 8 plasma plasma NOUN dti-1408 127 9 are be AUX dti-1408 127 10 correlated correlate VERB dti-1408 127 11 with with ADP dti-1408 127 12 each each DET dti-1408 127 13 other other ADJ dti-1408 127 14 in in ADP dti-1408 127 15 both both CCONJ dti-1408 127 16 healthy healthy ADJ dti-1408 127 17 volunteers volunteer NOUN dti-1408 127 18 and and CCONJ dti-1408 127 19 sick sick ADJ dti-1408 127 20 patients.24 patients.24 NOUN dti-1408 127 21 vasopressin vasopressin NOUN dti-1408 127 22 has have AUX dti-1408 127 23 been be AUX dti-1408 127 24 shown show VERB dti-1408 127 25 to to PART dti-1408 127 26 increase increase VERB dti-1408 127 27 epithelial epithelial ADJ dti-1408 127 28 permeability,21 permeability,21 NOUN dti-1408 127 29 but but CCONJ dti-1408 127 30 its its PRON dti-1408 127 31 effect effect NOUN dti-1408 127 32 on on ADP dti-1408 127 33 water water NOUN dti-1408 127 34 reabsorption reabsorption NOUN dti-1408 127 35 in in ADP dti-1408 127 36 the the DET dti-1408 127 37 gastrointestinal gastrointestinal ADJ dti-1408 127 38 tract tract NOUN dti-1408 127 39 has have AUX dti-1408 127 40 only only ADV dti-1408 127 41 been be AUX dti-1408 127 42 studied study VERB dti-1408 127 43 in in ADP dti-1408 127 44 pharmacological pharmacological ADJ dti-1408 127 45 doses dose NOUN dti-1408 127 46 of of ADP dti-1408 127 47 vasopressin vasopressin NOUN dti-1408 127 48 , , PUNCT dti-1408 127 49 and and CCONJ dti-1408 127 50 the the DET dti-1408 127 51 results result NOUN dti-1408 127 52 are be AUX dti-1408 127 53 not not PART dti-1408 127 54 conclusive.19,20 conclusive.19,20 NOUN dti-1408 127 55 as as SCONJ dti-1408 127 56 patients patient NOUN dti-1408 127 57 with with ADP dti-1408 127 58 ibd ibd PROPN dti-1408 127 59 and and CCONJ dti-1408 127 60 a a DET dti-1408 127 61 history history NOUN dti-1408 127 62 of of ADP dti-1408 127 63 bowel bowel NOUN dti-1408 127 64 resection resection NOUN dti-1408 127 65 had have VERB dti-1408 127 66 higher high ADJ dti-1408 127 67 plasma plasma NOUN dti-1408 127 68 levels level NOUN dti-1408 127 69 of of ADP dti-1408 127 70 copeptin copeptin NOUN dti-1408 127 71 , , PUNCT dti-1408 127 72 the the DET dti-1408 127 73 question question NOUN dti-1408 127 74 remains remain VERB dti-1408 127 75 whether whether SCONJ dti-1408 127 76 the the DET dti-1408 127 77 altered altered ADJ dti-1408 127 78 precursor precursor NOUN dti-1408 127 79 levels level NOUN dti-1408 127 80 measured measure VERB dti-1408 127 81 in in ADP dti-1408 127 82 plasma plasma NOUN dti-1408 127 83 are be AUX dti-1408 127 84 a a DET dti-1408 127 85 primary primary ADJ dti-1408 127 86 etiological etiological ADJ dti-1408 127 87 factor factor NOUN dti-1408 127 88 or or CCONJ dti-1408 127 89 a a DET dti-1408 127 90 secondary secondary ADJ dti-1408 127 91 effect effect NOUN dti-1408 127 92 of of ADP dti-1408 127 93 the the DET dti-1408 127 94 disease.7,36 disease.7,36 NOUN dti-1408 127 95 the the DET dti-1408 127 96 difference difference NOUN dti-1408 127 97 could could AUX dti-1408 127 98 hypothetically hypothetically ADV dti-1408 127 99 be be AUX dti-1408 127 100 explained explain VERB dti-1408 127 101 by by ADP dti-1408 127 102 a a DET dti-1408 127 103 compensatory compensatory ADJ dti-1408 127 104 mechanism mechanism NOUN dti-1408 127 105 due due ADP dti-1408 127 106 to to ADP dti-1408 127 107 a a DET dti-1408 127 108 shorter short ADJ dti-1408 127 109 bowel bowel NOUN dti-1408 127 110 , , PUNCT dti-1408 127 111 with with ADP dti-1408 127 112 ensuing ensue VERB dti-1408 127 113 reduced reduce VERB dti-1408 127 114 amount amount NOUN dti-1408 127 115 of of ADP dti-1408 127 116 vasopressin vasopressin NOUN dti-1408 127 117 receptors receptor NOUN dti-1408 127 118 and/or and/or CCONJ dti-1408 127 119 reduced reduce VERB dti-1408 127 120 water water NOUN dti-1408 127 121 reabsorption reabsorption NOUN dti-1408 127 122 capacity capacity NOUN dti-1408 127 123 of of ADP dti-1408 127 124 the the DET dti-1408 127 125 bowel.15,24 bowel.15,24 ADJ dti-1408 127 126 elevated elevated ADJ dti-1408 127 127 plasma plasma NOUN dti-1408 127 128 levels level NOUN dti-1408 127 129 of of ADP dti-1408 127 130 vasopressin vasopressin NOUN dti-1408 127 131 have have AUX dti-1408 127 132 been be AUX dti-1408 127 133 found find VERB dti-1408 127 134 in in ADP dti-1408 127 135 diseases disease NOUN dti-1408 127 136 characterized characterize VERB dti-1408 127 137 by by ADP dti-1408 127 138 chronic chronic ADJ dti-1408 127 139 inflammation.37 inflammation.37 PROPN dti-1408 127 140 in in ADP dti-1408 127 141 mice mouse NOUN dti-1408 127 142 , , PUNCT dti-1408 127 143 injections injection NOUN dti-1408 127 144 of of ADP dti-1408 127 145 vasopressin vasopressin NOUN dti-1408 127 146 into into ADP dti-1408 127 147 the the DET dti-1408 127 148 periaqueductal periaqueductal ADJ dti-1408 127 149 gray gray NOUN dti-1408 127 150 raised raise VERB dti-1408 127 151 the the DET dti-1408 127 152 plasma plasma NOUN dti-1408 127 153 levels level NOUN dti-1408 127 154 of of ADP dti-1408 127 155 all all DET dti-1408 127 156 enkephalins,38 enkephalins,38 NOUN dti-1408 127 157 and and CCONJ dti-1408 127 158 stimulation stimulation NOUN dti-1408 127 159 of of ADP dti-1408 127 160 peripheral peripheral ADJ dti-1408 127 161 vasopressin vasopressin NOUN dti-1408 127 162 receptors receptor NOUN dti-1408 127 163 had have VERB dti-1408 127 164 proinflammatory proinflammatory ADJ dti-1408 127 165 effects effect NOUN dti-1408 127 166 in in ADP dti-1408 127 167 experimental experimental ADJ dti-1408 127 168 colitis colitis NOUN dti-1408 127 169 , , PUNCT dti-1408 127 170 whereas whereas SCONJ dti-1408 127 171 inhibition inhibition NOUN dti-1408 127 172 of of ADP dti-1408 127 173 the the DET dti-1408 127 174 receptors receptor NOUN dti-1408 127 175 abolished abolish VERB dti-1408 127 176 the the DET dti-1408 127 177 vasopressin vasopressin NOUN dti-1408 127 178 effect.21 effect.21 VERB dti-1408 127 179 the the DET dti-1408 127 180 effect effect NOUN dti-1408 127 181 of of ADP dti-1408 127 182 vasopressin vasopressin NOUN dti-1408 127 183 on on ADP dti-1408 127 184 encephalin encephalin PROPN dti-1408 127 185 secretion secretion NOUN dti-1408 127 186 has have AUX dti-1408 127 187 not not PART dti-1408 127 188 been be AUX dti-1408 127 189 studied study VERB dti-1408 127 190 in in ADP dti-1408 127 191 humans human NOUN dti-1408 127 192 . . PUNCT dti-1408 128 1 proenkephalin proenkephalin PROPN dti-1408 128 2 is be AUX dti-1408 128 3 the the DET dti-1408 128 4 precursor precursor NOUN dti-1408 128 5 of of ADP dti-1408 128 6 met meet VERB dti-1408 128 7 - - PUNCT dti-1408 128 8 enkephalin enkephalin PROPN dti-1408 128 9 and and CCONJ dti-1408 128 10 leu leu PROPN dti-1408 128 11 - - PROPN dti-1408 128 12 enkephalin enkephalin PROPN dti-1408 128 13 , , PUNCT dti-1408 128 14 and and CCONJ dti-1408 128 15 in in ADP dti-1408 128 16 contrast contrast NOUN dti-1408 128 17 to to ADP dti-1408 128 18 the the DET dti-1408 128 19 findings finding NOUN dti-1408 128 20 in in ADP dti-1408 128 21 our our PRON dti-1408 128 22 study study NOUN dti-1408 128 23 with with ADP dti-1408 128 24 unaffected unaffected ADJ dti-1408 128 25 mr mr PROPN dti-1408 128 26 - - PUNCT dti-1408 128 27 penk penk NOUN dti-1408 128 28 a a PRON dti-1408 128 29 , , PUNCT dti-1408 128 30 plasma plasma NOUN dti-1408 128 31 levels level NOUN dti-1408 128 32 of of ADP dti-1408 128 33 met meet VERB dti-1408 128 34 - - PUNCT dti-1408 128 35 enkephalin enkephalin PROPN dti-1408 128 36 have have AUX dti-1408 128 37 previously previously ADV dti-1408 128 38 been be AUX dti-1408 128 39 shown show VERB dti-1408 128 40 to to PART dti-1408 128 41 be be AUX dti-1408 128 42 lowered lower VERB dti-1408 128 43 in in ADP dti-1408 128 44 ibd ibd PROPN dti-1408 128 45 patients.7,36 patients.7,36 VERB dti-1408 128 46 the the DET dti-1408 128 47 study study NOUN dti-1408 128 48 by by ADP dti-1408 128 49 owczarek owczarek NOUN dti-1408 128 50 et et PROPN dti-1408 128 51 al7 al7 PROPN dti-1408 128 52 was be AUX dti-1408 128 53 performed perform VERB dti-1408 128 54 in in ADP dti-1408 128 55 younger young ADJ dti-1408 128 56 patients patient NOUN dti-1408 128 57 with with ADP dti-1408 128 58 active active ADJ dti-1408 128 59 disease disease NOUN dti-1408 128 60 , , PUNCT dti-1408 128 61 which which PRON dti-1408 128 62 could could AUX dti-1408 128 63 exhaust exhaust VERB dti-1408 128 64 the the DET dti-1408 128 65 peptides peptide NOUN dti-1408 128 66 in in ADP dti-1408 128 67 the the DET dti-1408 128 68 blood blood NOUN dti-1408 128 69 circulation circulation NOUN dti-1408 128 70 and and CCONJ dti-1408 128 71 explain explain VERB dti-1408 128 72 the the DET dti-1408 128 73 different different ADJ dti-1408 128 74 results result NOUN dti-1408 128 75 . . PUNCT dti-1408 129 1 the the DET dti-1408 129 2 actual actual ADJ dti-1408 129 3 encephalin encephalin ADJ dti-1408 129 4 concentration concentration NOUN dti-1408 129 5 in in ADP dti-1408 129 6 the the DET dti-1408 129 7 gastrointestinal gastrointestinal ADJ dti-1408 129 8 tissue tissue NOUN dti-1408 129 9 is be AUX dti-1408 129 10 not not PART dti-1408 129 11 measured measure VERB dti-1408 129 12 , , PUNCT dti-1408 129 13 but but CCONJ dti-1408 129 14 agonists agonist NOUN dti-1408 129 15 to to ADP dti-1408 129 16 the the DET dti-1408 129 17 peripheral peripheral ADJ dti-1408 129 18 opioid opioid ADJ dti-1408 129 19 receptors receptor NOUN dti-1408 129 20 lead lead VERB dti-1408 129 21 to to ADP dti-1408 129 22 anti anti ADJ dti-1408 129 23 - - ADJ dti-1408 129 24 inflammatory inflammatory ADJ dti-1408 129 25 and and CCONJ dti-1408 129 26 anti anti ADJ dti-1408 129 27 - - ADJ dti-1408 129 28 nociceptive nociceptive ADJ dti-1408 129 29 effects.13 effects.13 NOUN dti-1408 130 1 these these DET dti-1408 130 2 studies study NOUN dti-1408 130 3 suggest suggest VERB dti-1408 130 4 a a DET dti-1408 130 5 role role NOUN dti-1408 130 6 of of ADP dti-1408 130 7 the the DET dti-1408 130 8 enkephalins enkephalin NOUN dti-1408 130 9 and and CCONJ dti-1408 130 10 their their PRON dti-1408 130 11 receptors receptor NOUN dti-1408 130 12 in in ADP dti-1408 130 13 disease disease NOUN dti-1408 130 14 activity activity NOUN dti-1408 130 15 . . PUNCT dti-1408 131 1 the the DET dti-1408 131 2 higher high ADJ dti-1408 131 3 levels level NOUN dti-1408 131 4 of of ADP dti-1408 131 5 copeptin copeptin NOUN dti-1408 131 6 in in ADP dti-1408 131 7 ibd ibd PROPN dti-1408 131 8 patients patient NOUN dti-1408 131 9 with with ADP dti-1408 131 10 a a DET dti-1408 131 11 bowel bowel NOUN dti-1408 131 12 resection resection NOUN dti-1408 131 13 may may AUX dti-1408 131 14 thus thus ADV dti-1408 131 15 be be AUX dti-1408 131 16 of of ADP dti-1408 131 17 interest interest NOUN dti-1408 131 18 , , PUNCT dti-1408 131 19 as as SCONJ dti-1408 131 20 vasopressin vasopressin NOUN dti-1408 131 21 may may AUX dti-1408 131 22 modulate modulate VERB dti-1408 131 23 gastrointestinal gastrointestinal ADJ dti-1408 131 24 inflammation inflammation NOUN dti-1408 131 25 , , PUNCT dti-1408 131 26 either either CCONJ dti-1408 131 27 directly38 directly38 NOUN dti-1408 131 28 or or CCONJ dti-1408 131 29 indirectly indirectly ADV dti-1408 131 30 through through ADP dti-1408 131 31 modulation modulation NOUN dti-1408 131 32 of of ADP dti-1408 131 33 proenkephalins proenkephalin NOUN dti-1408 131 34 and and CCONJ dti-1408 131 35 their their PRON dti-1408 131 36 stimulation stimulation NOUN dti-1408 131 37 of of ADP dti-1408 131 38 the the DET dti-1408 131 39 opioid opioid NOUN dti-1408 131 40 receptors.13,21 receptors.13,21 VERB dti-1408 131 41 the the DET dti-1408 131 42 role role NOUN dti-1408 131 43 of of ADP dti-1408 131 44 copeptin copeptin NOUN dti-1408 131 45 to to PART dti-1408 131 46 keep keep VERB dti-1408 131 47 the the DET dti-1408 131 48 ibd ibd NOUN dti-1408 131 49 patient patient NOUN dti-1408 131 50 in in ADP dti-1408 131 51 remission remission NOUN dti-1408 131 52 deserves deserve VERB dti-1408 131 53 to to PART dti-1408 131 54 be be AUX dti-1408 131 55 further far ADV dti-1408 131 56 examined examine VERB dti-1408 131 57 . . PUNCT dti-1408 132 1 ibs ib NOUN dti-1408 132 2 - - PUNCT dti-1408 132 3 like like ADJ dti-1408 132 4 symptoms symptom NOUN dti-1408 132 5 are be AUX dti-1408 132 6 present present ADJ dti-1408 132 7 in in ADP dti-1408 132 8 35%–40 35%–40 NUM dti-1408 132 9 % % NOUN dti-1408 132 10 of of ADP dti-1408 132 11 ibd ibd NOUN dti-1408 132 12 patients patient NOUN dti-1408 132 13 during during ADP dti-1408 132 14 remission remission NOUN dti-1408 132 15 . . PUNCT dti-1408 133 1 this this DET dti-1408 133 2 well well ADV dti-1408 133 3 - - PUNCT dti-1408 133 4 described describe VERB dti-1408 133 5 phenomenon phenomenon NOUN dti-1408 133 6 has have AUX dti-1408 133 7 for for ADP dti-1408 133 8 several several ADJ dti-1408 133 9 years year NOUN dti-1408 133 10 been be AUX dti-1408 133 11 believed believe VERB dti-1408 133 12 to to PART dti-1408 133 13 depend depend VERB dti-1408 133 14 on on ADP dti-1408 133 15 low low ADJ dti-1408 133 16 - - PUNCT dti-1408 133 17 grade grade NOUN dti-1408 133 18 inflammation.3 inflammation.3 NOUN dti-1408 133 19 very very ADV dti-1408 133 20 few few ADJ dti-1408 133 21 human human ADJ dti-1408 133 22 studies study NOUN dti-1408 133 23 have have AUX dti-1408 133 24 examined examine VERB dti-1408 133 25 the the DET dti-1408 133 26 effect effect NOUN dti-1408 133 27 of of ADP dti-1408 133 28 neuropeptides neuropeptide NOUN dti-1408 133 29 on on ADP dti-1408 133 30 visceral visceral ADJ dti-1408 133 31 pain pain NOUN dti-1408 133 32 , , PUNCT dti-1408 133 33 but but CCONJ dti-1408 133 34 a a DET dti-1408 133 35 connection connection NOUN dti-1408 133 36 between between ADP dti-1408 133 37 spinal spinal ADJ dti-1408 133 38 afferents afferent NOUN dti-1408 133 39 , , PUNCT dti-1408 133 40 enteric enteric ADJ dti-1408 133 41 mast mast NOUN dti-1408 133 42 cells cell NOUN dti-1408 133 43 , , PUNCT dti-1408 133 44 and and CCONJ dti-1408 133 45 the the DET dti-1408 133 46 ens ens NOUN dti-1408 133 47 has have AUX dti-1408 133 48 been be AUX dti-1408 133 49 confirmed confirm VERB dti-1408 133 50 , , PUNCT dti-1408 133 51 suggesting suggest VERB dti-1408 133 52 how how SCONJ dti-1408 133 53 elevation elevation NOUN dti-1408 133 54 of of ADP dti-1408 133 55 intestinal intestinal ADJ dti-1408 133 56 hypersensitivity hypersensitivity NOUN dti-1408 133 57 might might AUX dti-1408 133 58 occur occur VERB dti-1408 133 59 involving involve VERB dti-1408 133 60 neural neural ADJ dti-1408 133 61 peptides peptide NOUN dti-1408 133 62 , , PUNCT dti-1408 133 63 eg eg NOUN dti-1408 133 64 , , PUNCT dti-1408 133 65 neurotensin neurotensin NOUN dti-1408 133 66 and and CCONJ dti-1408 133 67 substance substance NOUN dti-1408 133 68 p.12,14 p.12,14 ADP dti-1408 133 69 substance substance NOUN dti-1408 133 70 p p NOUN dti-1408 133 71 has have AUX dti-1408 133 72 also also ADV dti-1408 133 73 been be AUX dti-1408 133 74 shown show VERB dti-1408 133 75 to to PART dti-1408 133 76 exert exert VERB dti-1408 133 77 proinflammatory proinflammatory ADJ dti-1408 133 78 effects effect NOUN dti-1408 133 79 , , PUNCT dti-1408 133 80 especially especially ADV dti-1408 133 81 on on ADP dti-1408 133 82 neurogenic neurogenic ADJ dti-1408 133 83 inflammation.11,14 inflammation.11,14 NOUN dti-1408 133 84 noninflamed noninflame VERB dti-1408 133 85 small small ADJ dti-1408 133 86 bowel bowel NOUN dti-1408 133 87 samples sample NOUN dti-1408 133 88 from from ADP dti-1408 133 89 patients patient NOUN dti-1408 133 90 with with ADP dti-1408 133 91 crohn crohn PROPN dti-1408 133 92 ’s ’s PART dti-1408 133 93 disease disease NOUN dti-1408 133 94 have have AUX dti-1408 133 95 shown show VERB dti-1408 133 96 increased increase VERB dti-1408 133 97 expression expression NOUN dti-1408 133 98 of of ADP dti-1408 133 99 substance substance NOUN dti-1408 133 100 p p X dti-1408 133 101 mrna mrna NOUN dti-1408 133 102 in in ADP dti-1408 133 103 one one NUM dti-1408 133 104 study,5 study,5 NOUN dti-1408 133 105 with with ADP dti-1408 133 106 more more ADJ dti-1408 133 107 binding bind VERB dti-1408 133 108 sites site NOUN dti-1408 133 109 in in ADP dti-1408 133 110 the the DET dti-1408 133 111 inflamed inflame VERB dti-1408 133 112 areas area NOUN dti-1408 133 113 , , PUNCT dti-1408 133 114 although although SCONJ dti-1408 133 115 unchanged unchanged ADJ dti-1408 133 116 mrna mrna PROPN dti-1408 133 117 levels level NOUN dti-1408 133 118 were be AUX dti-1408 133 119 found find VERB dti-1408 133 120 in in ADP dti-1408 133 121 another another DET dti-1408 133 122 study.6 study.6 ADJ dti-1408 133 123 plasma plasma NOUN dti-1408 133 124 levels level NOUN dti-1408 133 125 of of ADP dti-1408 133 126 substance substance NOUN dti-1408 133 127 p p NOUN dti-1408 133 128 have have AUX dti-1408 133 129 previously previously ADV dti-1408 133 130 been be AUX dti-1408 133 131 found find VERB dti-1408 133 132 to to PART dti-1408 133 133 be be AUX dti-1408 133 134 increased increase VERB dti-1408 133 135 in in ADP dti-1408 133 136 ibs ib NOUN dti-1408 133 137 patients patient NOUN dti-1408 133 138 but but CCONJ dti-1408 133 139 not not PART dti-1408 133 140 in in ADP dti-1408 133 141 ibd ibd NOUN dti-1408 133 142 patients patient NOUN dti-1408 133 143 with with ADP dti-1408 133 144 ibs ib NOUN dti-1408 133 145 - - PUNCT dti-1408 133 146 like like ADJ dti-1408 133 147 symptoms.39 symptoms.39 NOUN dti-1408 133 148 presence presence NOUN dti-1408 133 149 of of ADP dti-1408 133 150 ibs ibs PROPN dti-1408 133 151 - - PUNCT dti-1408 133 152 like like ADJ dti-1408 133 153 symptoms symptom NOUN dti-1408 133 154 was be AUX dti-1408 133 155 not not PART dti-1408 133 156 measured measure VERB dti-1408 133 157 in in ADP dti-1408 133 158 this this DET dti-1408 133 159 retrospective retrospective ADJ dti-1408 133 160 study study NOUN dti-1408 133 161 , , PUNCT dti-1408 133 162 but but CCONJ dti-1408 133 163 the the DET dti-1408 133 164 unaltered unaltered ADJ dti-1408 133 165 plasma plasma NOUN dti-1408 133 166 levels level NOUN dti-1408 133 167 of of ADP dti-1408 133 168 precursors precursor NOUN dti-1408 133 169 in in ADP dti-1408 133 170 the the DET dti-1408 133 171 current current ADJ dti-1408 133 172 study study NOUN dti-1408 133 173 do do VERB dti-1408 133 174 table table NOUN dti-1408 133 175 4 4 NUM dti-1408 133 176 . . PUNCT dti-1408 133 177 plasma plasma NOUN dti-1408 133 178 peptide peptide NOUN dti-1408 133 179 levels level NOUN dti-1408 133 180 from from ADP dti-1408 133 181 patients patient NOUN dti-1408 133 182 in in ADP dti-1408 133 183 malmö malmö PROPN dti-1408 133 184 diet diet PROPN dti-1408 133 185 and and CCONJ dti-1408 133 186 cancer cancer NOUN dti-1408 133 187 study study NOUN dti-1408 133 188 cardiovacsular cardiovacsular ADJ dti-1408 133 189 cohort cohort NOUN dti-1408 133 190 ( ( PUNCT dti-1408 133 191 mdc mdc NOUN dti-1408 133 192 - - PUNCT dti-1408 133 193 cc cc NOUN dti-1408 133 194 ) ) PUNCT dti-1408 133 195 compared compare VERB dti-1408 133 196 with with ADP dti-1408 133 197 controls control NOUN dti-1408 133 198 . . PUNCT dti-1408 134 1 mdc mdc NOUN dti-1408 134 2 - - PUNCT dti-1408 134 3 cc cc PROPN dti-1408 134 4 ( ( PUNCT dti-1408 134 5 n n NOUN dti-1408 134 6 = = NUM dti-1408 134 7 40 40 NUM dti-1408 134 8 ) ) PUNCT dti-1408 134 9 controls control NOUN dti-1408 134 10 ( ( PUNCT dti-1408 134 11 n n NOUN dti-1408 134 12 = = SYM dti-1408 134 13 120 120 NUM dti-1408 134 14 ) ) PUNCT dti-1408 134 15 p p ADJ dti-1408 134 16 - - PUNCT dti-1408 134 17 value value NOUN dti-1408 134 18 copeptin copeptin NOUN dti-1408 134 19 ( ( PUNCT dti-1408 134 20 pmol pmol X dti-1408 134 21 / / SYM dti-1408 134 22 l l NOUN dti-1408 134 23 ) ) PUNCT dti-1408 134 24 6.70 6.70 NUM dti-1408 134 25 ( ( PUNCT dti-1408 134 26 3.86–10.55 3.86–10.55 NUM dti-1408 134 27 ) ) PUNCT dti-1408 134 28 ( ( PUNCT dti-1408 134 29 34 34 NUM dti-1408 134 30 ) ) PUNCT dti-1408 134 31 5.65 5.65 NUM dti-1408 134 32 ( ( PUNCT dti-1408 134 33 3.23–8.42 3.23–8.42 NUM dti-1408 134 34 ) ) PUNCT dti-1408 134 35 ( ( PUNCT dti-1408 134 36 115 115 NUM dti-1408 134 37 ) ) PUNCT dti-1408 134 38 0.182 0.182 NUM dti-1408 134 39 mr mr PROPN dti-1408 134 40 - - PUNCT dti-1408 134 41 proadm proadm PROPN dti-1408 134 42 ( ( PUNCT dti-1408 134 43 nmol nmol NOUN dti-1408 134 44 / / SYM dti-1408 134 45 l l NOUN dti-1408 134 46 ) ) PUNCT dti-1408 134 47 0.45 0.45 NUM dti-1408 134 48 ( ( PUNCT dti-1408 134 49 0.38–0.54 0.38–0.54 NUM dti-1408 134 50 ) ) PUNCT dti-1408 134 51 ( ( PUNCT dti-1408 134 52 34 34 NUM dti-1408 134 53 ) ) PUNCT dti-1408 134 54 0.45 0.45 NUM dti-1408 134 55 ( ( PUNCT dti-1408 134 56 0.38–0.51 0.38–0.51 NUM dti-1408 134 57 ) ) PUNCT dti-1408 134 58 ( ( PUNCT dti-1408 134 59 116 116 NUM dti-1408 134 60 ) ) PUNCT dti-1408 134 61 0.489 0.489 NUM dti-1408 134 62 mr mr PROPN dti-1408 134 63 - - PUNCT dti-1408 134 64 proanp proanp PROPN dti-1408 134 65 ( ( PUNCT dti-1408 134 66 pmol pmol PROPN dti-1408 134 67 / / SYM dti-1408 134 68 l l NOUN dti-1408 134 69 ) ) PUNCT dti-1408 134 70 66.60 66.60 NUM dti-1408 134 71 ( ( PUNCT dti-1408 134 72 52.40–82.62 52.40–82.62 NUM dti-1408 134 73 ) ) PUNCT dti-1408 134 74 ( ( PUNCT dti-1408 134 75 34 34 NUM dti-1408 134 76 ) ) PUNCT dti-1408 134 77 65.85 65.85 NUM dti-1408 134 78 ( ( PUNCT dti-1408 134 79 47.38–85.65 47.38–85.65 NUM dti-1408 134 80 ) ) PUNCT dti-1408 134 81 ( ( PUNCT dti-1408 134 82 116 116 NUM dti-1408 134 83 ) ) PUNCT dti-1408 134 84 0.499 0.499 NUM dti-1408 134 85 mr mr PROPN dti-1408 134 86 - - PUNCT dti-1408 134 87 penk penk PROPN dti-1408 134 88 ( ( PUNCT dti-1408 134 89 pmol pmol X dti-1408 134 90 / / SYM dti-1408 134 91 l l NOUN dti-1408 134 92 ) ) PUNCT dti-1408 134 93 42.65 42.65 NUM dti-1408 134 94 ( ( PUNCT dti-1408 134 95 37.45–47.52 37.45–47.52 ADJ dti-1408 134 96 ) ) PUNCT dti-1408 134 97 ( ( PUNCT dti-1408 134 98 28 28 NUM dti-1408 134 99 ) ) PUNCT dti-1408 134 100 46.15 46.15 NUM dti-1408 134 101 ( ( PUNCT dti-1408 134 102 39.60–53.62 39.60–53.62 NUM dti-1408 134 103 ) ) PUNCT dti-1408 134 104 ( ( PUNCT dti-1408 134 105 106 106 NUM dti-1408 134 106 ) ) PUNCT dti-1408 134 107 0.086 0.086 NUM dti-1408 134 108 nt not PART dti-1408 134 109 - - PUNCT dti-1408 134 110 pta pta NOUN dti-1408 134 111 ( ( PUNCT dti-1408 134 112 pmol pmol X dti-1408 134 113 / / SYM dti-1408 134 114 l l NOUN dti-1408 134 115 ) ) PUNCT dti-1408 134 116 51.86 51.86 NUM dti-1408 134 117 ( ( PUNCT dti-1408 134 118 44.18–60.38 44.18–60.38 NUM dti-1408 134 119 ) ) PUNCT dti-1408 134 120 ( ( PUNCT dti-1408 134 121 28 28 NUM dti-1408 134 122 ) ) PUNCT dti-1408 134 123 51.01 51.01 NUM dti-1408 134 124 ( ( PUNCT dti-1408 134 125 41.00–61.67 41.00–61.67 NUM dti-1408 134 126 ) ) PUNCT dti-1408 134 127 ( ( PUNCT dti-1408 134 128 102 102 NUM dti-1408 134 129 ) ) PUNCT dti-1408 134 130 0.854 0.854 NUM dti-1408 134 131 proneurotensin proneurotensin NOUN dti-1408 134 132 ( ( PUNCT dti-1408 134 133 pmol pmol NOUN dti-1408 134 134 / / SYM dti-1408 134 135 l l NOUN dti-1408 134 136 ) ) PUNCT dti-1408 134 137 96.28 96.28 NUM dti-1408 134 138 ( ( PUNCT dti-1408 134 139 62.09–142.69 62.09–142.69 NOUN dti-1408 134 140 ) ) PUNCT dti-1408 134 141 ( ( PUNCT dti-1408 134 142 28 28 NUM dti-1408 134 143 ) ) PUNCT dti-1408 134 144 93.39 93.39 NUM dti-1408 134 145 ( ( PUNCT dti-1408 134 146 67.37–138.27 67.37–138.27 PROPN dti-1408 134 147 ) ) PUNCT dti-1408 134 148 ( ( PUNCT dti-1408 134 149 106 106 NUM dti-1408 134 150 ) ) PUNCT dti-1408 134 151 0.860 0.860 NUM dti-1408 134 152 notes note VERB dti-1408 134 153 : : PUNCT dti-1408 134 154 n n NOUN dti-1408 134 155 = = NOUN dti-1408 134 156 number number NOUN dti-1408 134 157 of of ADP dti-1408 134 158 analyses analysis NOUN dti-1408 134 159 . . PUNCT dti-1408 135 1 values value NOUN dti-1408 135 2 are be AUX dti-1408 135 3 given give VERB dti-1408 135 4 as as ADP dti-1408 135 5 median median PROPN dti-1408 135 6 [ [ X dti-1408 135 7 interquartile interquartile ADJ dti-1408 135 8 range range NOUN dti-1408 135 9 ( ( PUNCT dti-1408 135 10 iqr iqr NOUN dti-1408 135 11 ) ) PUNCT dti-1408 135 12 ] ] PUNCT dti-1408 135 13 . . PUNCT dti-1408 136 1 mann mann PROPN dti-1408 136 2 – – PUNCT dti-1408 136 3 whitney whitney PROPN dti-1408 136 4 u u NOUN dti-1408 136 5 - - NOUN dti-1408 136 6 test test NOUN dti-1408 136 7 . . PUNCT dti-1408 137 1 p p X dti-1408 137 2   NOUN dti-1408 137 3 0.05 0.05 NUM dti-1408 137 4 was be AUX dti-1408 137 5 considered consider VERB dti-1408 137 6 statistically statistically ADV dti-1408 137 7 significant significant ADJ dti-1408 137 8 . . PUNCT dti-1408 138 1 abbreviations abbreviation NOUN dti-1408 138 2 : : PUNCT dti-1408 138 3 ibd ibd NOUN dti-1408 138 4 , , PUNCT dti-1408 138 5 inflammatory inflammatory ADJ dti-1408 138 6 bowel bowel NOUN dti-1408 138 7 disease disease NOUN dti-1408 138 8 ; ; PUNCT dti-1408 138 9 mr mr PROPN dti-1408 138 10 - - PUNCT dti-1408 138 11 proadm proadm ADJ dti-1408 138 12 , , PUNCT dti-1408 138 13 midregional midregional ADJ dti-1408 138 14 fragment fragment NOUN dti-1408 138 15 of of ADP dti-1408 138 16 pro pro ADJ dti-1408 138 17 - - ADJ dti-1408 138 18 adrenomedullin adrenomedullin NOUN dti-1408 138 19 ; ; PUNCT dti-1408 138 20 mr mr PROPN dti-1408 138 21 - - PUNCT dti-1408 138 22 proanp proanp PROPN dti-1408 138 23 , , PUNCT dti-1408 138 24 midregional midregional ADJ dti-1408 138 25 fragment fragment NOUN dti-1408 138 26 of of ADP dti-1408 138 27 pro pro ADJ dti-1408 138 28 - - ADJ dti-1408 138 29 atrial atrial ADJ dti-1408 138 30 natriuretic natriuretic ADJ dti-1408 138 31 peptide peptide NOUN dti-1408 138 32 ; ; PUNCT dti-1408 138 33 mr mr PROPN dti-1408 138 34 - - PUNCT dti-1408 138 35 penk penk PROPN dti-1408 138 36 , , PUNCT dti-1408 138 37 midregional midregional ADJ dti-1408 138 38 fragment fragment NOUN dti-1408 138 39 of of ADP dti-1408 138 40 proenkephalin proenkephalin PROPN dti-1408 138 41 a a PRON dti-1408 138 42 ; ; PUNCT dti-1408 138 43 nt not PART dti-1408 138 44 - - PUNCT dti-1408 138 45 pta pta NOUN dti-1408 138 46 , , PUNCT dti-1408 138 47 n n CCONJ dti-1408 138 48 - - PUNCT dti-1408 138 49 terminal terminal ADJ dti-1408 138 50 polytachykinin polytachykinin PROPN dti-1408 138 51 a. a. NOUN dti-1408 138 52 http://www.la-press.com http://www.la-press.com X dti-1408 139 1 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 AUX dti-1408 139 2 ohlsson ohlsson NOUN dti-1408 139 3 and and CCONJ dti-1408 139 4 melander melander VERB dti-1408 139 5 26 26 NUM dti-1408 139 6 drug drug NOUN dti-1408 139 7 target target NOUN dti-1408 139 8 insights insight NOUN dti-1408 139 9 2015:9 2015:9 NUM dti-1408 139 10 not not PART dti-1408 139 11 suggest suggest VERB dti-1408 139 12 involvement involvement NOUN dti-1408 139 13 of of ADP dti-1408 139 14 peptides peptide NOUN dti-1408 139 15 for for ADP dti-1408 139 16 development development NOUN dti-1408 139 17 of of ADP dti-1408 139 18 gastrointestinal gastrointestinal ADJ dti-1408 139 19 symptoms symptom NOUN dti-1408 139 20 . . PUNCT dti-1408 140 1 the the DET dti-1408 140 2 limitation limitation NOUN dti-1408 140 3 of of ADP dti-1408 140 4 the the DET dti-1408 140 5 present present ADJ dti-1408 140 6 study study NOUN dti-1408 140 7 is be AUX dti-1408 140 8 the the DET dti-1408 140 9 small small ADJ dti-1408 140 10 study study NOUN dti-1408 140 11 population population NOUN dti-1408 140 12 . . PUNCT dti-1408 141 1 however however ADV dti-1408 141 2 , , PUNCT dti-1408 141 3 previous previous ADJ dti-1408 141 4 studies study NOUN dti-1408 141 5 in in ADP dti-1408 141 6 the the DET dti-1408 141 7 field field NOUN dti-1408 141 8 have have AUX dti-1408 141 9 been be AUX dti-1408 141 10 of of ADP dti-1408 141 11 smaller small ADJ dti-1408 141 12 or or CCONJ dti-1408 141 13 similar similar ADJ dti-1408 141 14 sizes.7,36 sizes.7,36 NOUN dti-1408 141 15 the the DET dti-1408 141 16 advantage advantage NOUN dti-1408 141 17 of of ADP dti-1408 141 18 measuring measure VERB dti-1408 141 19 precursors precursor NOUN dti-1408 141 20 instead instead ADV dti-1408 141 21 of of ADP dti-1408 141 22 peptides peptide NOUN dti-1408 141 23 depends depend VERB dti-1408 141 24 on on ADP dti-1408 141 25 the the DET dti-1408 141 26 high high ADJ dti-1408 141 27 stability stability NOUN dti-1408 141 28 of of ADP dti-1408 141 29 these these DET dti-1408 141 30 precursors precursor NOUN dti-1408 141 31 , , PUNCT dti-1408 141 32 which which PRON dti-1408 141 33 are be AUX dti-1408 141 34 synthesized synthesize VERB dti-1408 141 35 in in ADP dti-1408 141 36 stoichiometric stoichiometric ADJ dti-1408 141 37 amounts amount NOUN dti-1408 141 38 relative relative ADJ dti-1408 141 39 to to ADP dti-1408 141 40 the the DET dti-1408 141 41 mature mature NOUN dti-1408 141 42 peptides.23,24 peptides.23,24 NOUN dti-1408 141 43 the the DET dti-1408 141 44 strength strength NOUN dti-1408 141 45 is be AUX dti-1408 141 46 that that SCONJ dti-1408 141 47 we we PRON dti-1408 141 48 have have AUX dti-1408 141 49 analyzed analyze VERB dti-1408 141 50 several several ADJ dti-1408 141 51 precursors precursor NOUN dti-1408 141 52 in in ADP dti-1408 141 53 well well ADV dti-1408 141 54 - - PUNCT dti-1408 141 55 characterized characterize VERB dti-1408 141 56 cohorts cohort NOUN dti-1408 141 57 . . PUNCT dti-1408 142 1 higher high ADJ dti-1408 142 2 plasma plasma NOUN dti-1408 142 3 levels level NOUN dti-1408 142 4 of of ADP dti-1408 142 5 precursors precursor NOUN dti-1408 142 6 may may AUX dti-1408 142 7 be be AUX dti-1408 142 8 related relate VERB dti-1408 142 9 to to ADP dti-1408 142 10 a a DET dti-1408 142 11 reduced reduce VERB dti-1408 142 12 degradation degradation NOUN dti-1408 142 13 / / SYM dti-1408 142 14 excretion excretion NOUN dti-1408 142 15 in in ADP dti-1408 142 16 an an DET dti-1408 142 17 elder eld ADJ dti-1408 142 18 cohort cohort NOUN dti-1408 142 19 , , PUNCT dti-1408 142 20 rather rather ADV dti-1408 142 21 than than ADP dti-1408 142 22 an an DET dti-1408 142 23 altered altered ADJ dti-1408 142 24 expression expression NOUN dti-1408 142 25 / / SYM dti-1408 143 1 secretion.40 secretion.40 NOUN dti-1408 143 2 this this PRON dti-1408 143 3 means mean VERB dti-1408 143 4 that that SCONJ dti-1408 143 5 multiple multiple ADJ dti-1408 143 6 factors factor NOUN dti-1408 143 7 influence influence VERB dti-1408 143 8 the the DET dti-1408 143 9 precursor precursor NOUN dti-1408 143 10 levels level NOUN dti-1408 143 11 in in ADP dti-1408 143 12 plasma plasma NOUN dti-1408 143 13 . . PUNCT dti-1408 144 1 we we PRON dti-1408 144 2 have have AUX dti-1408 144 3 matched match VERB dti-1408 144 4 for for ADP dti-1408 144 5 age age NOUN dti-1408 144 6 , , PUNCT dti-1408 144 7 gender gender NOUN dti-1408 144 8 , , PUNCT dti-1408 144 9 smoking smoking NOUN dti-1408 144 10 habits habit NOUN dti-1408 144 11 , , PUNCT dti-1408 144 12 and and CCONJ dti-1408 144 13 bmi bmi NOUN dti-1408 144 14 , , PUNCT dti-1408 144 15 and and CCONJ dti-1408 144 16 excluded exclude VERB dti-1408 144 17 patients patient NOUN dti-1408 144 18 with with ADP dti-1408 144 19 cardiovascular cardiovascular ADJ dti-1408 144 20 diseases disease NOUN dti-1408 144 21 , , PUNCT dti-1408 144 22 diabetes diabetes NOUN dti-1408 144 23 mellitus mellitus NOUN dti-1408 144 24 , , PUNCT dti-1408 144 25 and and CCONJ dti-1408 144 26 malignancy malignancy NOUN dti-1408 144 27 , , PUNCT dti-1408 144 28 but but CCONJ dti-1408 144 29 factors factor NOUN dti-1408 144 30 such such ADJ dti-1408 144 31 as as ADP dti-1408 144 32 dietary dietary ADJ dti-1408 144 33 habits habit NOUN dti-1408 144 34 , , PUNCT dti-1408 144 35 alcohol alcohol NOUN dti-1408 144 36 intake intake NOUN dti-1408 144 37 , , PUNCT dti-1408 144 38 stress stress NOUN dti-1408 144 39 , , PUNCT dti-1408 144 40 physical physical ADJ dti-1408 144 41 activity activity NOUN dti-1408 144 42 , , PUNCT dti-1408 144 43 sleeping sleeping NOUN dti-1408 144 44 habits habit NOUN dti-1408 144 45 , , PUNCT dti-1408 144 46 and and CCONJ dti-1408 144 47 drug drug NOUN dti-1408 144 48 therapy therapy NOUN dti-1408 144 49 may may AUX dti-1408 144 50 also also ADV dti-1408 144 51 influence influence VERB dti-1408 144 52 the the DET dti-1408 144 53 secretion secretion NOUN dti-1408 144 54 and and CCONJ dti-1408 144 55 degradation degradation NOUN dti-1408 144 56 of of ADP dti-1408 144 57 precursors precursor NOUN dti-1408 144 58 . . PUNCT dti-1408 145 1 the the DET dti-1408 145 2 difference difference NOUN dti-1408 145 3 between between ADP dti-1408 145 4 the the DET dti-1408 145 5 two two NUM dti-1408 145 6 cohorts cohort NOUN dti-1408 145 7 regarding regard VERB dti-1408 145 8 plasma plasma NOUN dti-1408 145 9 values value NOUN dti-1408 145 10 of of ADP dti-1408 145 11 penk penk PROPN dti-1408 145 12 , , PUNCT dti-1408 145 13 pnt pnt PROPN dti-1408 145 14 , , PUNCT dti-1408 145 15 and and CCONJ dti-1408 145 16 pta pta PROPN dti-1408 145 17 may may AUX dti-1408 145 18 be be AUX dti-1408 145 19 reflected reflect VERB dti-1408 145 20 by by ADP dti-1408 145 21 the the DET dti-1408 145 22 different different ADJ dti-1408 145 23 factors factor NOUN dti-1408 145 24 mentioned mention VERB dti-1408 145 25 above above ADV dti-1408 145 26 . . PUNCT dti-1408 146 1 although although SCONJ dti-1408 146 2 not not PART dti-1408 146 3 statistically statistically ADV dti-1408 146 4 significant significant ADJ dti-1408 146 5 , , PUNCT dti-1408 146 6 there there PRON dti-1408 146 7 were be VERB dti-1408 146 8 more more ADJ dti-1408 146 9 cases case NOUN dti-1408 146 10 of of ADP dti-1408 146 11 crohn crohn NOUN dti-1408 146 12 ’s ’s PART dti-1408 146 13 disease disease NOUN dti-1408 146 14 in in ADP dti-1408 146 15 the the DET dti-1408 146 16 mdc mdc NOUN dti-1408 146 17 - - PUNCT dti-1408 146 18 cc cc NOUN dti-1408 146 19 cohort cohort NOUN dti-1408 146 20 than than ADP dti-1408 146 21 in in ADP dti-1408 146 22 the the DET dti-1408 146 23 mpm mpm NOUN dti-1408 146 24 cohort cohort NOUN dti-1408 146 25 , , PUNCT dti-1408 146 26 and and CCONJ dti-1408 146 27 also also ADV dti-1408 146 28 a a DET dti-1408 146 29 different different ADJ dti-1408 146 30 smoking smoking NOUN dti-1408 146 31 prevalence prevalence NOUN dti-1408 146 32 between between ADP dti-1408 146 33 the the DET dti-1408 146 34 two two NUM dti-1408 146 35 cohorts cohort NOUN dti-1408 146 36 . . PUNCT dti-1408 147 1 as as SCONJ dti-1408 147 2 data datum NOUN dti-1408 147 3 on on ADP dti-1408 147 4 the the DET dti-1408 147 5 mpm mpm NOUN dti-1408 147 6 cohort cohort NOUN dti-1408 147 7 were be AUX dti-1408 147 8 collected collect VERB dti-1408 147 9 several several ADJ dti-1408 147 10 years year NOUN dti-1408 147 11 before before ADP dti-1408 147 12 those those PRON dti-1408 147 13 of of ADP dti-1408 147 14 the the DET dti-1408 147 15 mdc mdc NOUN dti-1408 147 16 - - PUNCT dti-1408 147 17 cc cc NOUN dti-1408 147 18 cohort cohort NOUN dti-1408 147 19 , , PUNCT dti-1408 147 20 treatment treatment NOUN dti-1408 147 21 regimens regimen NOUN dti-1408 147 22 in in ADP dti-1408 147 23 the the DET dti-1408 147 24 daily daily ADJ dti-1408 147 25 clinic clinic NOUN dti-1408 147 26 also also ADV dti-1408 147 27 differed differ VERB dti-1408 147 28 , , PUNCT dti-1408 147 29 which which PRON dti-1408 147 30 may may AUX dti-1408 147 31 have have AUX dti-1408 147 32 influenced influence VERB dti-1408 147 33 the the DET dti-1408 147 34 precursor precursor NOUN dti-1408 147 35 secretion secretion NOUN dti-1408 147 36 . . PUNCT dti-1408 148 1 thus thus ADV dti-1408 148 2 , , PUNCT dti-1408 148 3 the the DET dti-1408 148 4 two two NUM dti-1408 148 5 cohorts cohort NOUN dti-1408 148 6 were be AUX dti-1408 148 7 not not PART dti-1408 148 8 matched match VERB dti-1408 148 9 or or CCONJ dti-1408 148 10 identical identical ADJ dti-1408 148 11 in in ADP dti-1408 148 12 composition composition NOUN dti-1408 148 13 . . PUNCT dti-1408 149 1 in in ADP dti-1408 149 2 conclusion conclusion NOUN dti-1408 149 3 , , PUNCT dti-1408 149 4 higher high ADJ dti-1408 149 5 basal basal ADJ dti-1408 149 6 plasma plasma NOUN dti-1408 149 7 levels level NOUN dti-1408 149 8 of of ADP dti-1408 149 9 copeptin copeptin NOUN dti-1408 149 10 were be AUX dti-1408 149 11 found find VERB dti-1408 149 12 in in ADP dti-1408 149 13 inactive inactive ADJ dti-1408 149 14 ibd ibd NOUN dti-1408 149 15 patients patient NOUN dti-1408 149 16 , , PUNCT dti-1408 149 17 whereas whereas SCONJ dti-1408 149 18 the the DET dti-1408 149 19 basal basal ADJ dti-1408 149 20 plasma plasma NOUN dti-1408 149 21 levels level NOUN dti-1408 149 22 of of ADP dti-1408 149 23 mr mr PROPN dti-1408 149 24 - - PUNCT dti-1408 149 25 proadm proadm PROPN dti-1408 149 26 , , PUNCT dti-1408 149 27 mr mr PROPN dti-1408 149 28 - - PUNCT dti-1408 149 29 proanp proanp PROPN dti-1408 149 30 , , PUNCT dti-1408 149 31 mr mr PROPN dti-1408 149 32 - - PUNCT dti-1408 149 33 penk penk PROPN dti-1408 149 34 a a X dti-1408 149 35 , , PUNCT dti-1408 149 36 ntpta ntpta NOUN dti-1408 149 37 , , PUNCT dti-1408 149 38 and and CCONJ dti-1408 149 39 proneurotensin proneurotensin NOUN dti-1408 149 40 were be AUX dti-1408 149 41 not not PART dti-1408 149 42 altered alter VERB dti-1408 149 43 in in ADP dti-1408 149 44 inactive inactive ADJ dti-1408 149 45 ibd ibd NOUN dti-1408 149 46 compared compare VERB dti-1408 149 47 with with ADP dti-1408 149 48 controls control NOUN dti-1408 149 49 in in ADP dti-1408 149 50 middle middle ADJ dti-1408 149 51 - - PUNCT dti-1408 149 52 aged aged ADJ dti-1408 149 53 subjects subject NOUN dti-1408 149 54 . . PUNCT dti-1408 150 1 elevated elevated ADJ dti-1408 150 2 copeptin copeptin NOUN dti-1408 150 3 levels level NOUN dti-1408 150 4 were be AUX dti-1408 150 5 found find VERB dti-1408 150 6 in in ADP dti-1408 150 7 ibd ibd NOUN dti-1408 150 8 patients patient NOUN dti-1408 150 9 who who PRON dti-1408 150 10 had have AUX dti-1408 150 11 undergone undergo VERB dti-1408 150 12 bowel bowel NOUN dti-1408 150 13 resection resection NOUN dti-1408 150 14 . . PUNCT dti-1408 151 1 the the DET dti-1408 151 2 role role NOUN dti-1408 151 3 of of ADP dti-1408 151 4 copeptin copeptin NOUN dti-1408 151 5 to to PART dti-1408 151 6 keep keep VERB dti-1408 151 7 the the DET dti-1408 151 8 ibd ibd NOUN dti-1408 151 9 patient patient NOUN dti-1408 151 10 in in ADP dti-1408 151 11 remission remission NOUN dti-1408 151 12 deserves deserve VERB dti-1408 151 13 to to PART dti-1408 151 14 be be AUX dti-1408 151 15 further far ADV dti-1408 151 16 examined examine VERB dti-1408 151 17 . . PUNCT dti-1408 152 1 list list NOUN dti-1408 152 2 of of ADP dti-1408 152 3 abbreviations abbreviation NOUN dti-1408 152 4 avp avp VERB dti-1408 152 5 , , PUNCT dti-1408 152 6 arginine arginine NOUN dti-1408 152 7 vasopressin vasopressin NOUN dti-1408 152 8 ; ; PUNCT dti-1408 152 9 bmi bmi NOUN dti-1408 152 10 , , PUNCT dti-1408 152 11 body body NOUN dti-1408 152 12 mass mass PROPN dti-1408 152 13 index index NOUN dti-1408 152 14 ; ; PUNCT dti-1408 152 15 ibd ibd NOUN dti-1408 152 16 , , PUNCT dti-1408 152 17 inflammatory inflammatory ADJ dti-1408 152 18 bowel bowel NOUN dti-1408 152 19 disease disease NOUN dti-1408 152 20 ; ; PUNCT dti-1408 152 21 mdc mdc NOUN dti-1408 152 22 - - PUNCT dti-1408 152 23 cc cc PROPN dti-1408 152 24 , , PUNCT dti-1408 152 25 malmö malmö PROPN dti-1408 152 26 diet diet PROPN dti-1408 152 27 and and CCONJ dti-1408 152 28 cancer cancer NOUN dti-1408 152 29 study study NOUN dti-1408 152 30 cardiovascular cardiovascular ADJ dti-1408 152 31 cohort cohort NOUN dti-1408 152 32 ; ; PUNCT dti-1408 152 33 mpm mpm PROPN dti-1408 152 34 , , PUNCT dti-1408 152 35 malmö malmö PROPN dti-1408 152 36 preventive preventive ADJ dti-1408 152 37 medicine medicine NOUN dti-1408 152 38 ; ; PUNCT dti-1408 152 39 mr mr PROPN dti-1408 152 40 - - PUNCT dti-1408 152 41 proadm proadm ADJ dti-1408 152 42 , , PUNCT dti-1408 152 43 midregional midregional ADJ dti-1408 152 44 fragment fragment NOUN dti-1408 152 45 of of ADP dti-1408 152 46 pro pro ADJ dti-1408 152 47 - - ADJ dti-1408 152 48 adrenomedullin adrenomedullin NOUN dti-1408 152 49 ; ; PUNCT dti-1408 152 50 mr mr PROPN dti-1408 152 51 - - PUNCT dti-1408 152 52 proanp proanp PROPN dti-1408 152 53 , , PUNCT dti-1408 152 54 midregional midregional ADJ dti-1408 152 55 fragment fragment NOUN dti-1408 152 56 of of ADP dti-1408 152 57 pro pro ADJ dti-1408 152 58 - - ADJ dti-1408 152 59 atrial atrial ADJ dti-1408 152 60 natriuretic natriuretic ADJ dti-1408 152 61 peptide peptide NOUN dti-1408 152 62 ; ; PUNCT dti-1408 152 63 mr mr PROPN dti-1408 152 64 - - PUNCT dti-1408 152 65 penk penk PROPN dti-1408 152 66 , , PUNCT dti-1408 152 67 midregional midregional ADJ dti-1408 152 68 fragment fragment NOUN dti-1408 152 69 of of ADP dti-1408 152 70 proenkephalin proenkephalin PROPN dti-1408 152 71 a a PRON dti-1408 152 72 ; ; PUNCT dti-1408 152 73 nt not PART dti-1408 152 74 - - PUNCT dti-1408 152 75 pta pta NOUN dti-1408 152 76 , , PUNCT dti-1408 152 77 n n CCONJ dti-1408 152 78 - - PUNCT dti-1408 152 79 terminal terminal ADJ dti-1408 152 80 polytachykinin polytachykinin PROPN dti-1408 152 81 a. a. NOUN dti-1408 152 82 author author NOUN dti-1408 152 83 contributions contribution NOUN dti-1408 152 84 made make VERB dti-1408 152 85 substantial substantial ADJ dti-1408 152 86 contributions contribution NOUN dti-1408 152 87 to to ADP dti-1408 152 88 the the DET dti-1408 152 89 conception conception NOUN dti-1408 152 90 and and CCONJ dti-1408 152 91 design design NOUN dti-1408 152 92 of of ADP dti-1408 152 93 the the DET dti-1408 152 94 study study NOUN dti-1408 152 95 , , PUNCT dti-1408 152 96 participated participate VERB dti-1408 152 97 in in ADP dti-1408 152 98 the the DET dti-1408 152 99 interpretation interpretation NOUN dti-1408 152 100 of of ADP dti-1408 152 101 the the DET dti-1408 152 102 statistical statistical ADJ dti-1408 152 103 analysis analysis NOUN dti-1408 152 104 , , PUNCT dti-1408 152 105 and and CCONJ dti-1408 152 106 financed finance VERB dti-1408 152 107 the the DET dti-1408 152 108 study study NOUN dti-1408 152 109 : : PUNCT dti-1408 152 110 bo bo NOUN dti-1408 152 111 , , PUNCT dti-1408 152 112 om om PROPN dti-1408 152 113 . . PUNCT dti-1408 152 114 validated validate VERB dti-1408 152 115 the the DET dti-1408 152 116 medical medical ADJ dti-1408 152 117 records record NOUN dti-1408 152 118 and and CCONJ dti-1408 152 119 wrote write VERB dti-1408 152 120 the the DET dti-1408 152 121 manuscript manuscript NOUN dti-1408 152 122 : : PUNCT dti-1408 153 1 bo bo PROPN dti-1408 153 2 . . PUNCT dti-1408 154 1 both both DET dti-1408 154 2 authors author NOUN dti-1408 154 3 were be AUX dti-1408 154 4 involved involve VERB dti-1408 154 5 in in ADP dti-1408 154 6 revising revise VERB dti-1408 154 7 the the DET dti-1408 154 8 manuscript manuscript NOUN dti-1408 154 9 critically critically ADV dti-1408 154 10 for for ADP dti-1408 154 11 important important ADJ dti-1408 154 12 intellectual intellectual ADJ dti-1408 154 13 content content NOUN dti-1408 154 14 , , PUNCT dti-1408 154 15 and and CCONJ dti-1408 154 16 approved approve VERB dti-1408 154 17 the the DET dti-1408 154 18 final final ADJ dti-1408 154 19 manuscript manuscript NOUN dti-1408 154 20 . . PUNCT dti-1408 155 1 references reference NOUN dti-1408 155 2 1 1 NUM dti-1408 155 3 . . PUNCT dti-1408 156 1 levite levite PROPN dti-1408 156 2 m m PROPN dti-1408 156 3 , , PUNCT dti-1408 156 4 chowers chowers PROPN dti-1408 156 5 y. y. PROPN dti-1408 156 6 nerve nerve NOUN dti-1408 156 7 - - PUNCT dti-1408 156 8 driven drive VERB dti-1408 156 9 immunity immunity NOUN dti-1408 156 10 : : PUNCT dti-1408 156 11 neuropeptides neuropeptide NOUN dti-1408 156 12 regulate regulate VERB dti-1408 156 13 cytokine cytokine ADJ dti-1408 156 14 secretion secretion NOUN dti-1408 156 15 of of ADP dti-1408 156 16 t t NOUN dti-1408 156 17 cells cell NOUN dti-1408 156 18 and and CCONJ dti-1408 156 19 intestinal intestinal ADJ dti-1408 156 20 epithelial epithelial ADJ dti-1408 156 21 cells cell NOUN dti-1408 156 22 in in ADP dti-1408 156 23 a a DET dti-1408 156 24 direct direct ADJ dti-1408 156 25 , , PUNCT dti-1408 156 26 powerful powerful ADJ dti-1408 156 27 and and CCONJ dti-1408 156 28 contextual contextual ADJ dti-1408 156 29 manner manner NOUN dti-1408 156 30 . . PUNCT dti-1408 157 1 ann ann PROPN dti-1408 157 2 oncol oncol PROPN dti-1408 157 3 . . PUNCT dti-1408 158 1 2001;12 2001;12 NOUN dti-1408 158 2 : : PUNCT dti-1408 158 3 s19 s19 PROPN dti-1408 158 4 – – PUNCT dti-1408 158 5 s25 s25 NOUN dti-1408 158 6 . . PUNCT dti-1408 159 1 2 2 NUM dti-1408 159 2 . . PUNCT dti-1408 159 3 margolis margolis PROPN dti-1408 159 4 kg kg PROPN dti-1408 159 5 , , PUNCT dti-1408 159 6 gershon gershon PROPN dti-1408 159 7 md md PROPN dti-1408 159 8 . . PROPN dti-1408 159 9 neuropeptides neuropeptide NOUN dti-1408 159 10 and and CCONJ dti-1408 159 11 inflammatory inflammatory ADJ dti-1408 159 12 bowel bowel NOUN dti-1408 159 13 disease disease NOUN dti-1408 159 14 . . PUNCT dti-1408 160 1 curr curr PROPN dti-1408 160 2 opin opin PROPN dti-1408 160 3 gastroenterol gastroenterol NOUN dti-1408 160 4 . . PUNCT dti-1408 161 1 2009;25:503–511 2009;25:503–511 NOUN dti-1408 161 2 . . PUNCT dti-1408 162 1 3 3 X dti-1408 162 2 . . X dti-1408 162 3 vivinus vivinus PROPN dti-1408 162 4 - - PUNCT dti-1408 162 5 nébot nébot NOUN dti-1408 162 6 m m NOUN dti-1408 162 7 , , PUNCT dti-1408 162 8 frin frin ADV dti-1408 162 9 - - PUNCT dti-1408 162 10 mathy mathy ADJ dti-1408 162 11 g g NOUN dti-1408 162 12 , , PUNCT dti-1408 162 13 bzioueche bzioueche PROPN dti-1408 162 14 h h PROPN dti-1408 162 15 , , PUNCT dti-1408 162 16 et et PROPN dti-1408 162 17 al al PROPN dti-1408 162 18 . . PUNCT dti-1408 162 19 functional functional ADJ dti-1408 162 20 bowel bowel NOUN dti-1408 162 21 symptoms symptom NOUN dti-1408 162 22 in in ADP dti-1408 162 23 quiescent quiescent ADJ dti-1408 162 24 inflammatory inflammatory ADJ dti-1408 162 25 bowel bowel NOUN dti-1408 162 26 diseases disease NOUN dti-1408 162 27 : : PUNCT dti-1408 162 28 role role NOUN dti-1408 162 29 of of ADP dti-1408 162 30 epithelial epithelial ADJ dti-1408 162 31 barrier barrier NOUN dti-1408 162 32 disruption disruption NOUN dti-1408 162 33 and and CCONJ dti-1408 162 34 low low ADJ dti-1408 162 35 - - PUNCT dti-1408 162 36 grade grade NOUN dti-1408 162 37 inflammation inflammation NOUN dti-1408 162 38 . . PUNCT dti-1408 163 1 gut gut INTJ dti-1408 163 2 . . PUNCT dti-1408 164 1 2014;63:744–752 2014;63:744–752 NOUN dti-1408 164 2 . . PUNCT dti-1408 165 1 4 4 X dti-1408 165 2 . . X dti-1408 165 3 ohlsson ohlsson PROPN dti-1408 165 4 b b PROPN dti-1408 165 5 , , PUNCT dti-1408 165 6 veress veress NOUN dti-1408 165 7 b b NOUN dti-1408 165 8 , , PUNCT dti-1408 165 9 lindgren lindgren PROPN dti-1408 165 10 s s PROPN dti-1408 165 11 , , PUNCT dti-1408 165 12 sundkvist sundkvist NOUN dti-1408 165 13 g. g. PROPN dti-1408 165 14 enteric enteric PROPN dti-1408 165 15 ganglioneuritis ganglioneuritis PROPN dti-1408 165 16 and and CCONJ dti-1408 165 17 abnormal abnormal ADJ dti-1408 165 18 interstitial interstitial ADJ dti-1408 165 19 cells cell NOUN dti-1408 165 20 of of ADP dti-1408 165 21 cajal cajal PROPN dti-1408 165 22 ; ; PUNCT dti-1408 165 23 features feature NOUN dti-1408 165 24 of of ADP dti-1408 165 25 inflammatory inflammatory ADJ dti-1408 165 26 bowel bowel NOUN dti-1408 165 27 disease disease NOUN dti-1408 165 28 . . PUNCT dti-1408 166 1 inflamm inflamm PROPN dti-1408 166 2 bowel bowel PROPN dti-1408 166 3 dis dis PROPN dti-1408 166 4 . . PUNCT dti-1408 167 1 2007;132:45–51 2007;132:45–51 NUM dti-1408 167 2 . . NOUN dti-1408 168 1 5 5 NUM dti-1408 168 2 . . X dti-1408 168 3 michalski michalski PROPN dti-1408 168 4 cw cw PROPN dti-1408 168 5 , , PUNCT dti-1408 168 6 autschbach autschbach PROPN dti-1408 168 7 f f PROPN dti-1408 168 8 , , PUNCT dti-1408 168 9 selvaggi selvaggi PROPN dti-1408 168 10 f f PROPN dti-1408 168 11 , , PUNCT dti-1408 168 12 et et PROPN dti-1408 168 13 al al PROPN dti-1408 168 14 . . PUNCT dti-1408 168 15 increase increase NOUN dti-1408 168 16 in in ADP dti-1408 168 17 substance substance NOUN dti-1408 168 18 p p PRON dti-1408 168 19 precursor precursor NOUN dti-1408 168 20 mrna mrna NOUN dti-1408 168 21 in in ADP dti-1408 168 22 noninflamed noninflame VERB dti-1408 168 23 small small ADJ dti-1408 168 24 - - PUNCT dti-1408 168 25 bowel bowel NOUN dti-1408 168 26 sections section NOUN dti-1408 168 27 in in ADP dti-1408 168 28 patients patient NOUN dti-1408 168 29 with with ADP dti-1408 168 30 crohn crohn PROPN dti-1408 168 31 ’s ’s PART dti-1408 168 32 disease disease NOUN dti-1408 168 33 . . PUNCT dti-1408 169 1 am be AUX dti-1408 169 2 j j PROPN dti-1408 169 3 surg surg PROPN dti-1408 169 4 . . PUNCT dti-1408 170 1 2007;193:476–481 2007;193:476–481 NUM dti-1408 170 2 . . NOUN dti-1408 171 1 6 6 NUM dti-1408 171 2 . . X dti-1408 171 3 ter ter NOUN dti-1408 171 4 beek beek PROPN dti-1408 171 5 wp wp PROPN dti-1408 171 6 , , PUNCT dti-1408 171 7 biemond biemond PROPN dti-1408 171 8 i i PRON dti-1408 171 9 , , PUNCT dti-1408 171 10 muller muller PROPN dti-1408 171 11 es es PROPN dti-1408 171 12 , , PUNCT dti-1408 171 13 van van PROPN dti-1408 171 14 den den PROPN dti-1408 171 15 berg berg PROPN dti-1408 171 16 m m PROPN dti-1408 171 17 , , PUNCT dti-1408 171 18 lamers lamers PROPN dti-1408 171 19 cb cb PROPN dti-1408 171 20 . . PROPN dti-1408 171 21 substance substance NOUN dti-1408 171 22 p p NOUN dti-1408 171 23 receptor receptor NOUN dti-1408 171 24 expression expression NOUN dti-1408 171 25 in in ADP dti-1408 171 26 patients patient NOUN dti-1408 171 27 with with ADP dti-1408 171 28 inflammatory inflammatory ADJ dti-1408 171 29 bowel bowel NOUN dti-1408 171 30 disease disease NOUN dti-1408 171 31 . . PUNCT dti-1408 172 1 determination determination NOUN dti-1408 172 2 by by ADP dti-1408 172 3 three three NUM dti-1408 172 4 different different ADJ dti-1408 172 5 techniques technique NOUN dti-1408 172 6 , , PUNCT dti-1408 172 7 i.e. i.e. X dti-1408 172 8 , , PUNCT dti-1408 172 9 storage storage NOUN dti-1408 172 10 phosphor phosphor NOUN dti-1408 172 11 autoradiography autoradiography NOUN dti-1408 172 12 , , PUNCT dti-1408 172 13 rt rt PROPN dti-1408 172 14 - - PUNCT dti-1408 172 15 pcr pcr PROPN dti-1408 172 16 and and CCONJ dti-1408 172 17 immunohistochemistry immunohistochemistry NOUN dti-1408 172 18 . . PUNCT dti-1408 173 1 neuropeptides neuropeptide NOUN dti-1408 173 2 . . PUNCT dti-1408 174 1 2007;41:301–306 2007;41:301–306 NUM dti-1408 174 2 . . PUNCT dti-1408 175 1 7 7 X dti-1408 175 2 . . X dti-1408 175 3 owczarek owczarek PROPN dti-1408 176 1 d d NOUN dti-1408 176 2 , , PUNCT dti-1408 176 3 cibor cibor NOUN dti-1408 176 4 d d NOUN dti-1408 176 5 , , PUNCT dti-1408 176 6 mach mach NOUN dti-1408 176 7 t t PROPN dti-1408 176 8 , , PUNCT dti-1408 176 9 et et PROPN dti-1408 176 10 al al PROPN dti-1408 176 11 . . PROPN dti-1408 176 12 met meet VERB dti-1408 176 13 - - PUNCT dti-1408 176 14 enkephalins enkephalin NOUN dti-1408 176 15 in in ADP dti-1408 176 16 patients patient NOUN dti-1408 176 17 with with ADP dti-1408 176 18 inflammatory inflammatory ADJ dti-1408 176 19 bowel bowel NOUN dti-1408 176 20 diseases disease NOUN dti-1408 176 21 . . PUNCT dti-1408 177 1 adv adv PROPN dti-1408 177 2 med med PROPN dti-1408 177 3 sci sci PROPN dti-1408 177 4 . . PUNCT dti-1408 178 1 2011;56:158–164 2011;56:158–164 PROPN dti-1408 178 2 . . PUNCT dti-1408 179 1 8 8 NUM dti-1408 179 2 . . X dti-1408 179 3 monstein monstein PROPN dti-1408 179 4 hj hj PROPN dti-1408 179 5 , , PUNCT dti-1408 179 6 grahn grahn VERB dti-1408 179 7 n n PRON dti-1408 179 8 , , PUNCT dti-1408 179 9 ohlsson ohlsson PROPN dti-1408 179 10 b. b. PROPN dti-1408 179 11 proenkephalin proenkephalin PROPN dti-1408 179 12 - - PUNCT dti-1408 179 13 a a DET dti-1408 179 14 mrna mrna NOUN dti-1408 179 15 is be AUX dti-1408 179 16 widely widely ADV dti-1408 179 17 expressed express VERB dti-1408 179 18 in in ADP dti-1408 179 19 tissues tissue NOUN dti-1408 179 20 of of ADP dti-1408 179 21 the the DET dti-1408 179 22 human human ADJ dti-1408 179 23 gastrointestinal gastrointestinal ADJ dti-1408 179 24 tract tract NOUN dti-1408 179 25 . . PUNCT dti-1408 180 1 eur eur PROPN dti-1408 180 2 surg surg NOUN dti-1408 180 3 res re NOUN dti-1408 180 4 . . PUNCT dti-1408 181 1 2006;38:464–468 2006;38:464–468 NUM dti-1408 181 2 . . NOUN dti-1408 181 3 9 9 NUM dti-1408 181 4 . . X dti-1408 181 5 egerod egerod PROPN dti-1408 181 6 kl kl PROPN dti-1408 181 7 , , PUNCT dti-1408 181 8 engelstoft engelstoft ADV dti-1408 181 9 ms ms NOUN dti-1408 181 10 , , PUNCT dti-1408 181 11 grunddal grunddal PROPN dti-1408 181 12 kv kv PROPN dti-1408 181 13 , , PUNCT dti-1408 181 14 et et PROPN dti-1408 181 15 al al PROPN dti-1408 181 16 . . PUNCT dti-1408 182 1 a a DET dti-1408 182 2 major major ADJ dti-1408 182 3 lineage lineage NOUN dti-1408 182 4 of of ADP dti-1408 182 5 enteroendocrine enteroendocrine ADJ dti-1408 182 6 cells cell NOUN dti-1408 182 7 coexpress coexpress PROPN dti-1408 182 8 cck cck NOUN dti-1408 182 9 , , PUNCT dti-1408 182 10 secretin secretin NOUN dti-1408 182 11 , , PUNCT dti-1408 182 12 gip gip NOUN dti-1408 182 13 , , PUNCT dti-1408 182 14 glp-1 glp-1 NOUN dti-1408 182 15 , , PUNCT dti-1408 182 16 pyy pyy NOUN dti-1408 182 17 , , PUNCT dti-1408 182 18 and and CCONJ dti-1408 182 19 neurotensin neurotensin NOUN dti-1408 182 20 but but CCONJ dti-1408 182 21 not not PART dti-1408 182 22 somatostatin somatostatin NOUN dti-1408 182 23 . . PUNCT dti-1408 183 1 endocrinology endocrinology NOUN dti-1408 183 2 . . PUNCT dti-1408 184 1 2012;153:5782–5795 2012;153:5782–5795 NUM dti-1408 184 2 . . NOUN dti-1408 185 1 10 10 NUM dti-1408 185 2 . . PUNCT dti-1408 186 1 ashizuka ashizuka PROPN dti-1408 186 2 s s PROPN dti-1408 186 3 , , PUNCT dti-1408 186 4 inatsu inatsu PROPN dti-1408 186 5 h h PROPN dti-1408 186 6 , , PUNCT dti-1408 186 7 inagaki inagaki PROPN dti-1408 186 8 - - PUNCT dti-1408 186 9 ohara ohara PROPN dti-1408 186 10 k k PROPN dti-1408 186 11 , , PUNCT dti-1408 186 12 kita kita PROPN dti-1408 186 13 t t PROPN dti-1408 186 14 , , PUNCT dti-1408 186 15 kitamura kitamura PROPN dti-1408 186 16 k. k. PROPN dti-1408 186 17 adrenomedullin adrenomedullin PROPN dti-1408 186 18 as as ADP dti-1408 186 19 a a DET dti-1408 186 20 potential potential ADJ dti-1408 186 21 therapeutic therapeutic ADJ dti-1408 186 22 agent agent NOUN dti-1408 186 23 for for ADP dti-1408 186 24 inflammatory inflammatory ADJ dti-1408 186 25 bowel bowel NOUN dti-1408 186 26 disease disease NOUN dti-1408 186 27 . . PUNCT dti-1408 187 1 curr curr PROPN dti-1408 187 2 protein protein PROPN dti-1408 187 3 pept pept PROPN dti-1408 187 4 sci sci PROPN dti-1408 187 5 . . PUNCT dti-1408 187 6 2013;14:246–255 2013;14:246–255 PROPN dti-1408 187 7 . . PROPN dti-1408 187 8 11 11 NUM dti-1408 187 9 . . PUNCT dti-1408 188 1 demir demir PROPN dti-1408 188 2 ie ie PROPN dti-1408 188 3 , , PUNCT dti-1408 188 4 schäfer schäfer PROPN dti-1408 188 5 kh kh PROPN dti-1408 188 6 , , PUNCT dti-1408 188 7 tieftrunk tieftrunk NOUN dti-1408 188 8 e e NOUN dti-1408 188 9 , , PUNCT dti-1408 188 10 friess friess ADJ dti-1408 188 11 h h PROPN dti-1408 188 12 , , PUNCT dti-1408 188 13 ceyhan ceyhan PROPN dti-1408 188 14 go go VERB dti-1408 188 15 . . PUNCT dti-1408 189 1 neural neural ADJ dti-1408 189 2 plasticity plasticity NOUN dti-1408 189 3 in in ADP dti-1408 189 4 the the DET dti-1408 189 5 gastrointestinal gastrointestinal ADJ dti-1408 189 6 tract tract NOUN dti-1408 189 7 : : PUNCT dti-1408 189 8 chronic chronic ADJ dti-1408 189 9 inflammation inflammation NOUN dti-1408 189 10 , , PUNCT dti-1408 189 11 neurotrophic neurotrophic ADJ dti-1408 189 12 signals signal NOUN dti-1408 189 13 , , PUNCT dti-1408 189 14 and and CCONJ dti-1408 189 15 hypersensitivity hypersensitivity NOUN dti-1408 189 16 . . PUNCT dti-1408 190 1 acta acta PROPN dti-1408 190 2 neuropathol neuropathol PROPN dti-1408 190 3 . . PUNCT dti-1408 191 1 2013;125:491–509 2013;125:491–509 NUM dti-1408 191 2 . . PUNCT dti-1408 192 1 12 12 NUM dti-1408 192 2 . . PUNCT dti-1408 192 3 gui gui PROPN dti-1408 192 4 x x PROPN dti-1408 192 5 , , PUNCT dti-1408 192 6 carraway carraway PROPN dti-1408 192 7 re re PROPN dti-1408 192 8 , , PUNCT dti-1408 192 9 dobner dobner NOUN dti-1408 192 10 pr pr X dti-1408 192 11 . . PUNCT dti-1408 193 1 endogenous endogenous ADJ dti-1408 193 2 neurotensin neurotensin NOUN dti-1408 193 3 facilitates facilitate VERB dti-1408 193 4 visceral visceral ADJ dti-1408 193 5 nociception nociception NOUN dti-1408 193 6 and and CCONJ dti-1408 193 7 is be AUX dti-1408 193 8 required require VERB dti-1408 193 9 for for ADP dti-1408 193 10 stress stress NOUN dti-1408 193 11 - - PUNCT dti-1408 193 12 induced induce VERB dti-1408 193 13 antinociception antinociception NOUN dti-1408 193 14 in in ADP dti-1408 193 15 mice mouse NOUN dti-1408 193 16 and and CCONJ dti-1408 193 17 rats rat NOUN dti-1408 193 18 . . PUNCT dti-1408 194 1 neuroscience neuroscience NOUN dti-1408 194 2 . . PUNCT dti-1408 195 1 2004;126:1023–1032 2004;126:1023–1032 X dti-1408 195 2 . . PROPN dti-1408 196 1 13 13 NUM dti-1408 196 2 . . PUNCT dti-1408 197 1 sobczak sobczak PROPN dti-1408 197 2 m m PROPN dti-1408 197 3 , , PUNCT dti-1408 197 4 pilarczyk pilarczyk VERB dti-1408 197 5 a a PRON dti-1408 197 6 , , PUNCT dti-1408 197 7 jonakowski jonakowski PROPN dti-1408 197 8 m m PROPN dti-1408 197 9 , , PUNCT dti-1408 197 10 et et PROPN dti-1408 197 11 al al PROPN dti-1408 197 12 . . PUNCT dti-1408 198 1 anti anti ADJ dti-1408 198 2 - - ADJ dti-1408 198 3 inflammatory inflammatory ADJ dti-1408 198 4 and and CCONJ dti-1408 198 5 antinociceptive antinociceptive ADJ dti-1408 198 6 action action NOUN dti-1408 198 7 of of ADP dti-1408 198 8 the the DET dti-1408 198 9 dimeric dimeric ADJ dti-1408 198 10 enkephalin enkephalin PROPN dti-1408 198 11 peptide peptide PROPN dti-1408 198 12 biphalin biphalin PROPN dti-1408 198 13 in in ADP dti-1408 198 14 the the DET dti-1408 198 15 mouse mouse NOUN dti-1408 198 16 model model NOUN dti-1408 198 17 of of ADP dti-1408 198 18 colitis colitis NOUN dti-1408 198 19 : : PUNCT dti-1408 198 20 new new ADJ dti-1408 198 21 potential potential ADJ dti-1408 198 22 treatment treatment NOUN dti-1408 198 23 of of ADP dti-1408 198 24 abdominal abdominal ADJ dti-1408 198 25 pain pain NOUN dti-1408 198 26 associated associate VERB dti-1408 198 27 with with ADP dti-1408 198 28 inflammatory inflammatory ADJ dti-1408 198 29 bowel bowel NOUN dti-1408 198 30 diseases disease NOUN dti-1408 198 31 . . PUNCT dti-1408 199 1 peptides peptide NOUN dti-1408 199 2 . . PUNCT dti-1408 200 1 2014;60:102–106 2014;60:102–106 NUM dti-1408 200 2 . . PUNCT dti-1408 201 1 14 14 NUM dti-1408 201 2 . . PUNCT dti-1408 202 1 wang wang PROPN dti-1408 202 2 gd gd PROPN dti-1408 202 3 , , PUNCT dti-1408 202 4 wang wang PROPN dti-1408 202 5 xy xy PROPN dti-1408 202 6 , , PUNCT dti-1408 202 7 liu liu PROPN dti-1408 202 8 s s PROPN dti-1408 202 9 , , PUNCT dti-1408 202 10 et et PROPN dti-1408 202 11 al al PROPN dti-1408 202 12 . . PROPN dti-1408 202 13 innervation innervation NOUN dti-1408 202 14 of of ADP dti-1408 202 15 enteric enteric ADJ dti-1408 202 16 mast mast NOUN dti-1408 202 17 cells cell NOUN dti-1408 202 18 by by ADP dti-1408 202 19 primary primary ADJ dti-1408 202 20 spinal spinal ADJ dti-1408 202 21 afferents afferent NOUN dti-1408 202 22 in in ADP dti-1408 202 23 guinea guinea NOUN dti-1408 202 24 pig pig NOUN dti-1408 202 25 and and CCONJ dti-1408 202 26 human human ADJ dti-1408 202 27 small small ADJ dti-1408 202 28 intestine intestine NOUN dti-1408 202 29 . . PUNCT dti-1408 202 30 am be AUX dti-1408 202 31 j j PROPN dti-1408 202 32 physiol physiol PROPN dti-1408 202 33 gastrointest gastrointest PROPN dti-1408 202 34 liver liver PROPN dti-1408 202 35 physiol physiol PROPN dti-1408 202 36 . . PUNCT dti-1408 203 1 2014;307 2014;307 NUM dti-1408 203 2 : : PUNCT dti-1408 203 3 g719 g719 PROPN dti-1408 203 4 – – PUNCT dti-1408 203 5 g731 g731 PROPN dti-1408 203 6 . . PUNCT dti-1408 204 1 15 15 NUM dti-1408 204 2 . . PUNCT dti-1408 204 3 monstein monstein PROPN dti-1408 204 4 hj hj PROPN dti-1408 204 5 , , PUNCT dti-1408 204 6 truedsson truedsson PROPN dti-1408 204 7 m m PROPN dti-1408 204 8 , , PUNCT dti-1408 204 9 ryberg ryberg NOUN dti-1408 204 10 a a PRON dti-1408 204 11 , , PUNCT dti-1408 204 12 ohlsson ohlsson PROPN dti-1408 204 13 b. b. PROPN dti-1408 204 14 vasopressin vasopressin PROPN dti-1408 204 15 receptor receptor NOUN dti-1408 204 16 mrna mrna NOUN dti-1408 204 17 expression expression NOUN dti-1408 204 18 in in ADP dti-1408 204 19 the the DET dti-1408 204 20 human human ADJ dti-1408 204 21 gastrointestinal gastrointestinal ADJ dti-1408 204 22 tract tract NOUN dti-1408 204 23 . . PUNCT dti-1408 205 1 eur eur PROPN dti-1408 205 2 surg surg NOUN dti-1408 205 3 res re NOUN dti-1408 205 4 . . PUNCT dti-1408 206 1 2008;40:34–40 2008;40:34–40 NUM dti-1408 206 2 . . X dti-1408 207 1 16 16 NUM dti-1408 207 2 . . PUNCT dti-1408 208 1 deen deen PROPN dti-1408 208 2 pm pm PROPN dti-1408 208 3 , , PUNCT dti-1408 208 4 verdijk verdijk PROPN dti-1408 208 5 ma ma PROPN dti-1408 208 6 , , PUNCT dti-1408 208 7 knoers knoer VERB dti-1408 208 8 nv nv PROPN dti-1408 208 9 , , PUNCT dti-1408 208 10 et et PROPN dti-1408 208 11 al al PROPN dti-1408 208 12 . . PROPN dti-1408 208 13 requirement requirement NOUN dti-1408 208 14 of of ADP dti-1408 208 15 human human ADJ dti-1408 208 16 renal renal ADJ dti-1408 208 17 water water NOUN dti-1408 208 18 channel channel NOUN dti-1408 208 19 aquaporin-2 aquaporin-2 NUM dti-1408 208 20 for for ADP dti-1408 208 21 vasopressin vasopressin NOUN dti-1408 208 22 - - PUNCT dti-1408 208 23 dependent dependent ADJ dti-1408 208 24 concentration concentration NOUN dti-1408 208 25 of of ADP dti-1408 208 26 urine urine NOUN dti-1408 208 27 . . PUNCT dti-1408 209 1 science science NOUN dti-1408 209 2 . . PUNCT dti-1408 210 1 1994;264:92–95 1994;264:92–95 NUM dti-1408 210 2 . . NOUN dti-1408 211 1 17 17 NUM dti-1408 211 2 . . PUNCT dti-1408 212 1 byron byron PROPN dti-1408 212 2 kl kl PROPN dti-1408 212 3 . . PROPN dti-1408 212 4 vasoprressin vasoprressin PROPN dti-1408 212 5 stimulates stimulate VERB dti-1408 212 6 ca2 ca2 PROPN dti-1408 212 7 + + CCONJ dti-1408 212 8 spiking spike VERB dti-1408 212 9 activity activity NOUN dti-1408 212 10 in in ADP dti-1408 212 11 a7r5 a7r5 VERB dti-1408 212 12 vascular vascular ADJ dti-1408 212 13 smooth smooth ADJ dti-1408 212 14 muscle muscle NOUN dti-1408 212 15 cells cell NOUN dti-1408 212 16 via via ADP dti-1408 212 17 activation activation NOUN dti-1408 212 18 of of ADP dti-1408 212 19 phospholipase phospholipase NOUN dti-1408 212 20 a2 a2 PROPN dti-1408 212 21 . . PUNCT dti-1408 213 1 circ circ PROPN dti-1408 213 2 res re NOUN dti-1408 213 3 . . PUNCT dti-1408 214 1 1996;78:813–820 1996;78:813–820 NOUN dti-1408 214 2 . . PUNCT dti-1408 215 1 18 18 NUM dti-1408 215 2 . . PUNCT dti-1408 216 1 decaux decaux VERB dti-1408 216 2 g g NOUN dti-1408 216 3 , , PUNCT dti-1408 216 4 soupart soupart VERB dti-1408 216 5 a a DET dti-1408 216 6 , , PUNCT dti-1408 216 7 vassart vassart NOUN dti-1408 216 8 g. g. PROPN dti-1408 216 9 non non ADJ dti-1408 216 10 - - ADJ dti-1408 216 11 peptide peptide ADJ dti-1408 216 12 arginine arginine NOUN dti-1408 216 13 - - PUNCT dti-1408 216 14 vasopressin vasopressin NOUN dti-1408 216 15 antagonists antagonist NOUN dti-1408 216 16 : : PUNCT dti-1408 216 17 the the DET dti-1408 216 18 vptans vptan NOUN dti-1408 216 19 . . PUNCT dti-1408 217 1 lancet lancet NOUN dti-1408 217 2 . . PUNCT dti-1408 218 1 2008;371:1624–1632 2008;371:1624–1632 X dti-1408 218 2 . . X dti-1408 219 1 19 19 NUM dti-1408 219 2 . . X dti-1408 219 3 levitan levitan PROPN dti-1408 219 4 r r PROPN dti-1408 219 5 , , PUNCT dti-1408 219 6 mauer mauer PROPN dti-1408 219 7 i. i. PROPN dti-1408 219 8 effect effect NOUN dti-1408 219 9 of of ADP dti-1408 219 10 intravenous intravenous ADJ dti-1408 219 11 antidiuretic antidiuretic ADJ dti-1408 219 12 hormone hormone NOUN dti-1408 219 13 administration administration NOUN dti-1408 219 14 on on ADP dti-1408 219 15 salt salt NOUN dti-1408 219 16 and and CCONJ dti-1408 219 17 water water NOUN dti-1408 219 18 absorption absorption NOUN dti-1408 219 19 from from ADP dti-1408 219 20 the the DET dti-1408 219 21 human human ADJ dti-1408 219 22 colon colon NOUN dti-1408 219 23 . . PUNCT dti-1408 220 1 j j PROPN dti-1408 220 2 lab lab PROPN dti-1408 220 3 clin clin PROPN dti-1408 220 4 med med PROPN dti-1408 220 5 . . PUNCT dti-1408 221 1 1968;72 1968;72 NUM dti-1408 221 2 : : PUNCT dti-1408 222 1 739–746 739–746 NUM dti-1408 222 2 . . NOUN dti-1408 222 3 20 20 NUM dti-1408 222 4 . . PUNCT dti-1408 223 1 soergel soergel PROPN dti-1408 223 2 kh kh PROPN dti-1408 223 3 , , PUNCT dti-1408 223 4 whalen whalen PROPN dti-1408 223 5 ge ge PROPN dti-1408 223 6 , , PUNCT dti-1408 223 7 harris harris PROPN dti-1408 223 8 ja ja PROPN dti-1408 223 9 , , PUNCT dti-1408 223 10 geenen geenen PROPN dti-1408 223 11 je je PROPN dti-1408 223 12 . . PROPN dti-1408 223 13 effect effect NOUN dti-1408 223 14 of of ADP dti-1408 223 15 antidiuretic antidiuretic ADJ dti-1408 223 16 hormone hormone NOUN dti-1408 223 17 on on ADP dti-1408 223 18 human human ADJ dti-1408 223 19 small small ADJ dti-1408 223 20 intestinal intestinal ADJ dti-1408 223 21 water water NOUN dti-1408 223 22 and and CCONJ dti-1408 223 23 solute solute NOUN dti-1408 223 24 transport transport NOUN dti-1408 223 25 . . PUNCT dti-1408 224 1 j j PROPN dti-1408 224 2 clin clin PROPN dti-1408 224 3 invest invest PROPN dti-1408 224 4 . . PUNCT dti-1408 225 1 1968;47 1968;47 NUM dti-1408 225 2 : : PUNCT dti-1408 225 3 1071–1082 1071–1082 NUM dti-1408 225 4 . . PUNCT dti-1408 226 1 21 21 NUM dti-1408 226 2 . . PUNCT dti-1408 227 1 ferrier ferrier PROPN dti-1408 227 2 l l PROPN dti-1408 227 3 , , PUNCT dti-1408 227 4 serradeil serradeil NOUN dti-1408 227 5 - - PUNCT dti-1408 227 6 le le X dti-1408 227 7 gal gal PROPN dti-1408 227 8 c c X dti-1408 227 9 , , PUNCT dti-1408 227 10 schulte schulte PROPN dti-1408 227 11 am am PROPN dti-1408 227 12 , , PUNCT dti-1408 227 13 et et PROPN dti-1408 227 14 al al PROPN dti-1408 227 15 . . PUNCT dti-1408 227 16 proinflammatory proinflammatory ADJ dti-1408 227 17 role role NOUN dti-1408 227 18 of of ADP dti-1408 227 19 vasopressin vasopressin NOUN dti-1408 227 20 through through ADP dti-1408 227 21 v1b v1b NOUN dti-1408 227 22 receptors receptor NOUN dti-1408 227 23 in in ADP dti-1408 227 24 hapten hapten VERB dti-1408 227 25 - - PUNCT dti-1408 227 26 induced induce VERB dti-1408 227 27 experimental experimental ADJ dti-1408 227 28 colitis colitis NOUN dti-1408 227 29 in in ADP dti-1408 227 30 rodents rodent NOUN dti-1408 227 31 : : PUNCT dti-1408 227 32 implication implication NOUN dti-1408 227 33 in in ADP dti-1408 227 34 ibd ibd PROPN dti-1408 227 35 . . PUNCT dti-1408 228 1 am be AUX dti-1408 228 2 j j PROPN dti-1408 228 3 physiol physiol PROPN dti-1408 228 4 gastrointest gastrointest PROPN dti-1408 228 5 liver liver PROPN dti-1408 228 6 physiol physiol NOUN dti-1408 228 7 . . PUNCT dti-1408 229 1 2010;299 2010;299 NUM dti-1408 229 2 : : PUNCT dti-1408 229 3 g1298 g1298 NOUN dti-1408 229 4 – – PUNCT dti-1408 229 5 g1307 g1307 NOUN dti-1408 229 6 . . NOUN dti-1408 229 7 22 22 NUM dti-1408 229 8 . . PUNCT dti-1408 229 9 aardal aardal PROPN dti-1408 229 10 s s PROPN dti-1408 229 11 , , PUNCT dti-1408 229 12 helle helle PROPN dti-1408 229 13 kb kb PROPN dti-1408 229 14 . . PUNCT dti-1408 230 1 comparative comparative ADJ dti-1408 230 2 aspects aspect NOUN dti-1408 230 3 of of ADP dti-1408 230 4 the the DET dti-1408 230 5 endocrine endocrine ADJ dti-1408 230 6 myocardium myocardium NOUN dti-1408 230 7 . . PUNCT dti-1408 231 1 acta acta PROPN dti-1408 231 2 physiol physiol PROPN dti-1408 231 3 scand scand PROPN dti-1408 231 4 suppl suppl PROPN dti-1408 231 5 . . PUNCT dti-1408 232 1 1991;599:31–46 1991;599:31–46 NUM dti-1408 232 2 . . NOUN dti-1408 232 3 23 23 NUM dti-1408 232 4 . . PUNCT dti-1408 233 1 ernst ernst PROPN dti-1408 233 2 a a PRON dti-1408 233 3 , , PUNCT dti-1408 233 4 kohrle kohrle PROPN dti-1408 233 5 j j PROPN dti-1408 233 6 , , PUNCT dti-1408 233 7 bergmann bergmann PROPN dti-1408 233 8 a. a. PROPN dti-1408 233 9 proenkephalin proenkephalin PROPN dti-1408 233 10 a a DET dti-1408 233 11 119–159 119–159 NUM dti-1408 233 12 , , PUNCT dti-1408 233 13 a a DET dti-1408 233 14 stable stable ADJ dti-1408 233 15 proenkephalin proenkephalin NOUN dti-1408 233 16 a a DET dti-1408 233 17 precursor precursor NOUN dti-1408 233 18 fragment fragment NOUN dti-1408 233 19 identified identify VERB dti-1408 233 20 in in ADP dti-1408 233 21 human human ADJ dti-1408 233 22 circulation circulation NOUN dti-1408 233 23 . . PUNCT dti-1408 234 1 peptides peptide NOUN dti-1408 234 2 . . PUNCT dti-1408 235 1 2006;27 2006;27 NUM dti-1408 235 2 : : PUNCT dti-1408 236 1 1835–1840 1835–1840 NUM dti-1408 236 2 . . PUNCT dti-1408 237 1 24 24 NUM dti-1408 237 2 . . PUNCT dti-1408 238 1 jochberger jochberger PROPN dti-1408 238 2 s s PROPN dti-1408 238 3 , , PUNCT dti-1408 238 4 morgenthaler morgenthaler PROPN dti-1408 238 5 ng ng PROPN dti-1408 238 6 , , PUNCT dti-1408 238 7 mayr mayr PROPN dti-1408 238 8 vd vd PROPN dti-1408 238 9 , , PUNCT dti-1408 238 10 et et PROPN dti-1408 238 11 al al PROPN dti-1408 238 12 . . PROPN dti-1408 238 13 copeptin copeptin PROPN dti-1408 238 14 and and CCONJ dti-1408 238 15 arginine arginine NOUN dti-1408 238 16 vasopressin vasopressin NOUN dti-1408 238 17 concentrations concentration NOUN dti-1408 238 18 in in ADP dti-1408 238 19 critically critically ADV dti-1408 238 20 ill ill ADJ dti-1408 238 21 patients patient NOUN dti-1408 238 22 . . PUNCT dti-1408 239 1 j j PROPN dti-1408 239 2 clin clin PROPN dti-1408 239 3 endocrinol endocrinol PROPN dti-1408 239 4 metab metab NOUN dti-1408 239 5 . . PUNCT dti-1408 240 1 2006;91 2006;91 NOUN dti-1408 240 2 : : PUNCT dti-1408 240 3 4381–4386 4381–4386 NUM dti-1408 240 4 . . X dti-1408 241 1 25 25 NUM dti-1408 241 2 . . PUNCT dti-1408 241 3 berglund berglund PROPN dti-1408 241 4 g g PROPN dti-1408 241 5 , , PUNCT dti-1408 241 6 eriksson eriksson PROPN dti-1408 241 7 kf kf PROPN dti-1408 241 8 , , PUNCT dti-1408 241 9 israelsson israelsson NOUN dti-1408 241 10 b b PROPN dti-1408 241 11 , , PUNCT dti-1408 241 12 et et PROPN dti-1408 241 13 al al PROPN dti-1408 241 14 . . PUNCT dti-1408 242 1 cardiovascular cardiovascular ADJ dti-1408 242 2 risk risk NOUN dti-1408 242 3 groups group NOUN dti-1408 242 4 and and CCONJ dti-1408 242 5 mortality mortality NOUN dti-1408 242 6 in in ADP dti-1408 242 7 an an DET dti-1408 242 8 urban urban ADJ dti-1408 242 9 swedish swedish ADJ dti-1408 242 10 male male ADJ dti-1408 242 11 population population NOUN dti-1408 242 12 : : PUNCT dti-1408 242 13 the the DET dti-1408 242 14 malmö malmö PROPN dti-1408 242 15 preventive preventive ADJ dti-1408 242 16 project project NOUN dti-1408 242 17 . . PUNCT dti-1408 243 1 j j PROPN dti-1408 243 2 intern intern PROPN dti-1408 243 3 med me VERB dti-1408 243 4 . . PUNCT dti-1408 244 1 1996;239:489–497 1996;239:489–497 NUM dti-1408 244 2 . . PUNCT dti-1408 245 1 26 26 NUM dti-1408 245 2 . . PUNCT dti-1408 246 1 persson persson PROPN dti-1408 246 2 m m PROPN dti-1408 246 3 , , PUNCT dti-1408 246 4 berglund berglund PROPN dti-1408 246 5 g g PROPN dti-1408 246 6 , , PUNCT dti-1408 246 7 nelson nelson PROPN dti-1408 246 8 jj jj PROPN dti-1408 246 9 , , PUNCT dti-1408 246 10 hedblad hedblad PROPN dti-1408 246 11 b. b. PROPN dti-1408 247 1 lp lp ADJ dti-1408 247 2 - - PUNCT dti-1408 247 3 pla2 pla2 NOUN dti-1408 247 4 activity activity NOUN dti-1408 247 5 and and CCONJ dti-1408 247 6 mass mass NOUN dti-1408 247 7 are be AUX dti-1408 247 8 associated associate VERB dti-1408 247 9 with with ADP dti-1408 247 10 increased increase VERB dti-1408 247 11 incidence incidence NOUN dti-1408 247 12 of of ADP dti-1408 247 13 ischemic ischemic ADJ dti-1408 247 14 stroke stroke NOUN dti-1408 247 15 : : PUNCT dti-1408 247 16 a a DET dti-1408 247 17 population population NOUN dti-1408 247 18 - - PUNCT dti-1408 247 19 based base VERB dti-1408 247 20 cohort cohort NOUN dti-1408 247 21 study study NOUN dti-1408 247 22 from from ADP dti-1408 247 23 malmö malmö PROPN dti-1408 247 24 , , PUNCT dti-1408 247 25 sweden sweden PROPN dti-1408 247 26 . . PUNCT dti-1408 247 27 atherosclerosis atherosclerosis NOUN dti-1408 247 28 . . PUNCT dti-1408 248 1 2008;200:191–198 2008;200:191–198 NUM dti-1408 248 2 . . PUNCT dti-1408 249 1 27 27 NUM dti-1408 249 2 . . PUNCT dti-1408 250 1 enhörning enhörne VERB dti-1408 250 2 s s PROPN dti-1408 250 3 , , PUNCT dti-1408 250 4 wang wang PROPN dti-1408 250 5 tj tj PROPN dti-1408 250 6 , , PUNCT dti-1408 250 7 nilsson nilsson PROPN dti-1408 250 8 pm pm PROPN dti-1408 250 9 , , PUNCT dti-1408 250 10 et et PROPN dti-1408 250 11 al al PROPN dti-1408 250 12 . . PUNCT dti-1408 250 13 plasma plasma NOUN dti-1408 250 14 copeptin copeptin NOUN dti-1408 250 15 and and CCONJ dti-1408 250 16 the the DET dti-1408 250 17 risk risk NOUN dti-1408 250 18 of of ADP dti-1408 250 19 diabetes diabetes NOUN dti-1408 250 20 mellitus mellitus NOUN dti-1408 250 21 . . PUNCT dti-1408 251 1 circulation circulation NOUN dti-1408 251 2 . . PUNCT dti-1408 252 1 2010;121:2102–2108 2010;121:2102–2108 NUM dti-1408 252 2 . . PUNCT dti-1408 252 3 http://www.la-press.com http://www.la-press.com X dti-1408 253 1 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1408 253 2 basal basal ADJ dti-1408 253 3 plasma plasma NOUN dti-1408 253 4 levels level NOUN dti-1408 253 5 of of ADP dti-1408 253 6 copeptin copeptin NOUN dti-1408 253 7 in in ADP dti-1408 253 8 ibd ibd PROPN dti-1408 253 9 27drug 27drug NUM dti-1408 253 10 target target NOUN dti-1408 253 11 insights insight NOUN dti-1408 253 12 2015:9 2015:9 DET dti-1408 253 13 28 28 NUM dti-1408 253 14 . . PUNCT dti-1408 254 1 melander melander PROPN dti-1408 254 2 o o NOUN dti-1408 254 3 , , PUNCT dti-1408 254 4 maisel maisel ADJ dti-1408 254 5 as as ADP dti-1408 254 6 , , PUNCT dti-1408 254 7 almgren almgren ADJ dti-1408 254 8 p p X dti-1408 254 9 , , PUNCT dti-1408 254 10 et et PROPN dti-1408 254 11 al al PROPN dti-1408 254 12 . . PUNCT dti-1408 254 13 plasma plasma NOUN dti-1408 254 14 proneurotensin proneurotensin NOUN dti-1408 254 15 and and CCONJ dti-1408 254 16 incidence incidence NOUN dti-1408 254 17 of of ADP dti-1408 254 18 diabetes diabetes NOUN dti-1408 254 19 , , PUNCT dti-1408 254 20 cardiovascular cardiovascular ADJ dti-1408 254 21 disease disease NOUN dti-1408 254 22 , , PUNCT dti-1408 254 23 breast breast NOUN dti-1408 254 24 cancer cancer NOUN dti-1408 254 25 , , PUNCT dti-1408 254 26 and and CCONJ dti-1408 254 27 mortality mortality NOUN dti-1408 254 28 . . PUNCT dti-1408 255 1 jama jama PROPN dti-1408 255 2 . . PUNCT dti-1408 256 1 2012;308:1469–1475 2012;308:1469–1475 X dti-1408 256 2 . . X dti-1408 257 1 29 29 NUM dti-1408 257 2 . . PUNCT dti-1408 258 1 fenske fenske PROPN dti-1408 258 2 w w PROPN dti-1408 258 3 , , PUNCT dti-1408 258 4 stork stork NOUN dti-1408 258 5 s s PROPN dti-1408 258 6 , , PUNCT dti-1408 258 7 blechschmidt blechschmidt VERB dti-1408 258 8 a a PRON dti-1408 258 9 , , PUNCT dti-1408 258 10 maier maier PROPN dti-1408 258 11 sg sg PROPN dti-1408 258 12 , , PUNCT dti-1408 258 13 morgenthaler morgenthaler PROPN dti-1408 258 14 ng ng PROPN dti-1408 258 15 , , PUNCT dti-1408 258 16 allolio allolio PROPN dti-1408 258 17 b. b. PROPN dti-1408 258 18 copeptin copeptin PROPN dti-1408 258 19 in in ADP dti-1408 258 20 the the DET dti-1408 258 21 differential differential ADJ dti-1408 258 22 diagnosis diagnosis NOUN dti-1408 258 23 of of ADP dti-1408 258 24 hyponatremia hyponatremia PROPN dti-1408 258 25 . . PUNCT dti-1408 259 1 j j PROPN dti-1408 259 2 clin clin PROPN dti-1408 259 3 endocrinol endocrinol PROPN dti-1408 259 4 metab metab NOUN dti-1408 259 5 . . PUNCT dti-1408 260 1 2009;94:123–129 2009;94:123–129 NUM dti-1408 260 2 . . PROPN dti-1408 260 3 30 30 NUM dti-1408 260 4 . . PUNCT dti-1408 261 1 morgenthaler morgenthaler PROPN dti-1408 261 2 ng ng PROPN dti-1408 261 3 , , PUNCT dti-1408 261 4 struck strike VERB dti-1408 261 5 j j PROPN dti-1408 261 6 , , PUNCT dti-1408 261 7 thomas thomas PROPN dti-1408 261 8 b b PROPN dti-1408 261 9 , , PUNCT dti-1408 261 10 bergmann bergmann PROPN dti-1408 261 11 a. a. PROPN dti-1408 261 12 immunoluminometric immunoluminometric PROPN dti-1408 261 13 assay assay VERB dti-1408 261 14 for for ADP dti-1408 261 15 the the DET dti-1408 261 16 midregion midregion NOUN dti-1408 261 17 of of ADP dti-1408 261 18 pro pro ADJ dti-1408 261 19 - - ADJ dti-1408 261 20 atrial atrial ADJ dti-1408 261 21 natriuretic natriuretic ADJ dti-1408 261 22 peptide peptide NOUN dti-1408 261 23 in in ADP dti-1408 261 24 human human ADJ dti-1408 261 25 plasma plasma NOUN dti-1408 261 26 . . PUNCT dti-1408 262 1 clin clin PROPN dti-1408 262 2 chem chem PROPN dti-1408 262 3 . . PUNCT dti-1408 263 1 2004;50:234–236 2004;50:234–236 NUM dti-1408 263 2 . . PROPN dti-1408 264 1 31 31 NUM dti-1408 264 2 . . PUNCT dti-1408 265 1 morgenthaler morgenthaler PROPN dti-1408 265 2 ng ng PROPN dti-1408 265 3 , , PUNCT dti-1408 265 4 struck strike VERB dti-1408 265 5 j j PROPN dti-1408 265 6 , , PUNCT dti-1408 265 7 alonso alonso PROPN dti-1408 265 8 c c PROPN dti-1408 265 9 , , PUNCT dti-1408 265 10 bergmann bergmann PROPN dti-1408 265 11 a. a. PROPN dti-1408 265 12 measurement measurement PROPN dti-1408 265 13 of of ADP dti-1408 265 14 midregional midregional ADJ dti-1408 265 15 proadrenomedullin proadrenomedullin NOUN dti-1408 265 16 in in ADP dti-1408 265 17 plasma plasma NOUN dti-1408 265 18 with with ADP dti-1408 265 19 an an DET dti-1408 265 20 immunoluminometric immunoluminometric NOUN dti-1408 265 21 assay assay NOUN dti-1408 265 22 . . PUNCT dti-1408 266 1 clin clin PROPN dti-1408 266 2 chem chem PROPN dti-1408 266 3 . . PUNCT dti-1408 267 1 2005;51:1823–1829 2005;51:1823–1829 NOUN dti-1408 267 2 . . PUNCT dti-1408 268 1 32 32 NUM dti-1408 268 2 . . PUNCT dti-1408 269 1 ernst ernst PROPN dti-1408 269 2 a a PRON dti-1408 269 3 , , PUNCT dti-1408 269 4 suhr suhr PROPN dti-1408 269 5 j j PROPN dti-1408 269 6 , , PUNCT dti-1408 269 7 kohrle kohrle PROPN dti-1408 269 8 j j PROPN dti-1408 269 9 , , PUNCT dti-1408 269 10 bergmann bergmann PROPN dti-1408 269 11 a. a. NOUN dti-1408 269 12 detection detection NOUN dti-1408 269 13 of of ADP dti-1408 269 14 stable stable ADJ dti-1408 269 15 n n CCONJ dti-1408 269 16 - - PUNCT dti-1408 269 17 terminal terminal ADJ dti-1408 269 18 protachykinin protachykinin NOUN dti-1408 269 19 a a DET dti-1408 269 20 immunoreactivity immunoreactivity NOUN dti-1408 269 21 in in ADP dti-1408 269 22 human human ADJ dti-1408 269 23 plasma plasma NOUN dti-1408 269 24 and and CCONJ dti-1408 269 25 cerebrospinal cerebrospinal ADJ dti-1408 269 26 fluid fluid NOUN dti-1408 269 27 . . PUNCT dti-1408 270 1 peptides peptide NOUN dti-1408 270 2 . . PUNCT dti-1408 271 1 2008 2008 NUM dti-1408 271 2 ; ; PUNCT dti-1408 272 1 29:1201–1206 29:1201–1206 X dti-1408 272 2 . . PUNCT dti-1408 273 1 33 33 NUM dti-1408 273 2 . . PUNCT dti-1408 274 1 ernst ernst PROPN dti-1408 274 2 a a PROPN dti-1408 274 3 , , PUNCT dti-1408 274 4 hellmich hellmich NOUN dti-1408 274 5 s s PART dti-1408 274 6 , , PUNCT dti-1408 274 7 bergmann bergmann PROPN dti-1408 274 8 a. a. PROPN dti-1408 274 9 proneurotensin proneurotensin PROPN dti-1408 274 10 1–117 1–117 NUM dti-1408 274 11 , , PUNCT dti-1408 274 12 a a DET dti-1408 274 13 stable stable ADJ dti-1408 274 14 neurotensin neurotensin NOUN dti-1408 274 15 precursor precursor NOUN dti-1408 274 16 fragment fragment NOUN dti-1408 274 17 identified identify VERB dti-1408 274 18 in in ADP dti-1408 274 19 human human ADJ dti-1408 274 20 circulation circulation NOUN dti-1408 274 21 . . PUNCT dti-1408 275 1 peptides peptide NOUN dti-1408 275 2 . . PUNCT dti-1408 276 1 2006;27:1787–1793 2006;27:1787–1793 NUM dti-1408 276 2 . . PUNCT dti-1408 277 1 34 34 NUM dti-1408 277 2 . . PUNCT dti-1408 277 3 khan khan PROPN dti-1408 277 4 wi wi PROPN dti-1408 277 5 , , PUNCT dti-1408 277 6 ghia ghia PROPN dti-1408 277 7 je je PROPN dti-1408 277 8 . . PUNCT dti-1408 278 1 gut gut NOUN dti-1408 278 2 hormones hormone NOUN dti-1408 278 3 : : PUNCT dti-1408 278 4 emerging emerge VERB dti-1408 278 5 role role NOUN dti-1408 278 6 in in ADP dti-1408 278 7 immune immune ADJ dti-1408 278 8 activation activation NOUN dti-1408 278 9 and and CCONJ dti-1408 278 10 inflammation inflammation NOUN dti-1408 278 11 . . PUNCT dti-1408 279 1 clin clin PROPN dti-1408 279 2 exp exp NOUN dti-1408 279 3 immunol immunol NOUN dti-1408 279 4 . . PUNCT dti-1408 280 1 2010;161:19–27 2010;161:19–27 NUM dti-1408 280 2 . . PROPN dti-1408 280 3 35 35 NUM dti-1408 280 4 . . PUNCT dti-1408 280 5 bonaz bonaz PROPN dti-1408 280 6 bl bl PROPN dti-1408 280 7 , , PUNCT dti-1408 280 8 bernstein bernstein PROPN dti-1408 280 9 cn cn PROPN dti-1408 280 10 . . PUNCT dti-1408 280 11 brain brain NOUN dti-1408 280 12 - - PUNCT dti-1408 280 13 gut gut NOUN dti-1408 280 14 interactions interaction NOUN dti-1408 280 15 in in ADP dti-1408 280 16 inflammatory inflammatory ADJ dti-1408 280 17 bowel bowel NOUN dti-1408 280 18 disease disease NOUN dti-1408 280 19 . . PUNCT dti-1408 281 1 gastroenterology gastroenterology NOUN dti-1408 281 2 . . PUNCT dti-1408 282 1 2013;144:36–49 2013;144:36–49 NUM dti-1408 282 2 . . PUNCT dti-1408 283 1 36 36 NUM dti-1408 283 2 . . PUNCT dti-1408 284 1 wiedermann wiedermann PROPN dti-1408 284 2 cj cj NOUN dti-1408 284 3 , , PUNCT dti-1408 284 4 sacerdote sacerdote VERB dti-1408 284 5 p p NOUN dti-1408 284 6 , , PUNCT dti-1408 284 7 propst propst NOUN dti-1408 284 8 a a PRON dti-1408 284 9 , , PUNCT dti-1408 284 10 et et PROPN dti-1408 284 11 al al PROPN dti-1408 284 12 . . PROPN dti-1408 284 13 decreased decrease VERB dti-1408 284 14 beta beta NOUN dti-1408 284 15 - - PUNCT dti-1408 284 16 endorphin endorphin NOUN dti-1408 284 17 content content NOUN dti-1408 284 18 in in ADP dti-1408 284 19 peripheral peripheral ADJ dti-1408 284 20 blood blood NOUN dti-1408 284 21 mononuclear mononuclear ADJ dti-1408 284 22 leukocytes leukocyte NOUN dti-1408 284 23 from from ADP dti-1408 284 24 patients patient NOUN dti-1408 284 25 with with ADP dti-1408 284 26 crohn crohn PROPN dti-1408 284 27 ’s ’s PART dti-1408 284 28 disease disease NOUN dti-1408 284 29 . . PUNCT dti-1408 285 1 brain brain NOUN dti-1408 285 2 behav behav PROPN dti-1408 285 3 immun immun PROPN dti-1408 285 4 . . PUNCT dti-1408 286 1 1994;8:261–269 1994;8:261–269 X dti-1408 286 2 . . PROPN dti-1408 286 3 37 37 NUM dti-1408 286 4 . . PUNCT dti-1408 287 1 han han PROPN dti-1408 287 2 dm dm PROPN dti-1408 287 3 , , PUNCT dti-1408 287 4 zhang zhang PROPN dti-1408 287 5 yq yq PROPN dti-1408 287 6 , , PUNCT dti-1408 287 7 bai bai PROPN dti-1408 287 8 qx qx PROPN dti-1408 287 9 , , PUNCT dti-1408 287 10 chen chen PROPN dti-1408 287 11 xq xq PROPN dti-1408 287 12 . . PROPN dti-1408 288 1 assay assay PROPN dti-1408 288 2 of of ADP dti-1408 288 3 avp avp PROPN dti-1408 288 4 , , PUNCT dti-1408 288 5 crp crp PROPN dti-1408 288 6 , , PUNCT dti-1408 288 7 and and CCONJ dti-1408 288 8 lps lps PROPN dti-1408 288 9 in in ADP dti-1408 288 10 leukemia leukemia NOUN dti-1408 288 11 . . PUNCT dti-1408 289 1 int int NOUN dti-1408 289 2 j j PROPN dti-1408 289 3 lab lab NOUN dti-1408 289 4 hematol hematol NOUN dti-1408 289 5 . . PUNCT dti-1408 290 1 2007;29:185–189 2007;29:185–189 NOUN dti-1408 290 2 . . PUNCT dti-1408 291 1 38 38 NUM dti-1408 291 2 . . PUNCT dti-1408 292 1 yang yang PROPN dti-1408 292 2 j j PROPN dti-1408 292 3 , , PUNCT dti-1408 292 4 yang yang PROPN dti-1408 292 5 y y PROPN dti-1408 292 6 , , PUNCT dti-1408 292 7 xu xu PROPN dti-1408 293 1 ht ht PROPN dti-1408 293 2 , , PUNCT dti-1408 293 3 chen chen PROPN dti-1408 293 4 jm jm PROPN dti-1408 293 5 , , PUNCT dti-1408 293 6 liu liu PROPN dti-1408 293 7 wy wy PROPN dti-1408 293 8 , , PUNCT dti-1408 293 9 lin lin PROPN dti-1408 293 10 bc bc PROPN dti-1408 293 11 . . PROPN dti-1408 293 12 arginine arginine PROPN dti-1408 293 13 vasopressin vasopressin NOUN dti-1408 293 14 induces induce VERB dti-1408 293 15 periaqueductal periaqueductal ADJ dti-1408 293 16 grey grey ADJ dti-1408 293 17 release release NOUN dti-1408 293 18 of of ADP dti-1408 293 19 encephalin encephalin NOUN dti-1408 293 20 and and CCONJ dti-1408 293 21 endorphin endorphin NOUN dti-1408 293 22 relating relate VERB dti-1408 293 23 to to ADP dti-1408 293 24 pain pain NOUN dti-1408 293 25 modulation modulation NOUN dti-1408 293 26 in in ADP dti-1408 293 27 the the DET dti-1408 293 28 rat rat NOUN dti-1408 293 29 . . PROPN dti-1408 293 30 regul regul PROPN dti-1408 293 31 pept pept PROPN dti-1408 293 32 . . PUNCT dti-1408 294 1 2007;142:29–36 2007;142:29–36 NUM dti-1408 294 2 . . NOUN dti-1408 294 3 39 39 NUM dti-1408 294 4 . . PUNCT dti-1408 295 1 keszthelyi keszthelyi ADV dti-1408 295 2 d d NOUN dti-1408 295 3 , , PUNCT dti-1408 295 4 troost troost PROPN dti-1408 295 5 fj fj PROPN dti-1408 295 6 , , PUNCT dti-1408 295 7 jonkers jonkers PROPN dti-1408 295 8 dm dm PROPN dti-1408 295 9 , , PUNCT dti-1408 295 10 et et PROPN dti-1408 295 11 al al PROPN dti-1408 295 12 . . PUNCT dti-1408 295 13 alterations alteration NOUN dti-1408 295 14 in in ADP dti-1408 295 15 mucosal mucosal ADJ dti-1408 295 16 neuropeptides neuropeptide NOUN dti-1408 295 17 in in ADP dti-1408 295 18 patients patient NOUN dti-1408 295 19 with with ADP dti-1408 295 20 irritable irritable ADJ dti-1408 295 21 bowel bowel NOUN dti-1408 295 22 syndrome syndrome NOUN dti-1408 295 23 and and CCONJ dti-1408 295 24 ulcerative ulcerative ADJ dti-1408 295 25 colitis colitis NOUN dti-1408 295 26 in in ADP dti-1408 295 27 remission remission NOUN dti-1408 295 28 : : PUNCT dti-1408 295 29 a a DET dti-1408 295 30 role role NOUN dti-1408 295 31 in in ADP dti-1408 295 32 pain pain NOUN dti-1408 295 33 symptom symptom NOUN dti-1408 295 34 generation generation NOUN dti-1408 295 35 ? ? PUNCT dti-1408 296 1 eur eur PROPN dti-1408 296 2 j j PROPN dti-1408 296 3 pain pain NOUN dti-1408 296 4 . . PUNCT dti-1408 297 1 2013;17:1299–1306 2013;17:1299–1306 ADJ dti-1408 297 2 . . PUNCT dti-1408 298 1 40 40 NUM dti-1408 298 2 . . PUNCT dti-1408 298 3 bhandari bhandari PROPN dti-1408 298 4 ss ss PROPN dti-1408 298 5 , , PUNCT dti-1408 298 6 loke loke ADV dti-1408 298 7 i i PRON dti-1408 298 8 , , PUNCT dti-1408 298 9 davies davies PROPN dti-1408 298 10 je je PROPN dti-1408 298 11 , , PUNCT dti-1408 298 12 squire squire PROPN dti-1408 298 13 ib ib PROPN dti-1408 298 14 , , PUNCT dti-1408 298 15 struck strike VERB dti-1408 298 16 j j PROPN dti-1408 298 17 , , PUNCT dti-1408 298 18 ng ng PROPN dti-1408 298 19 ll ll NOUN dti-1408 298 20 . . PUNCT dti-1408 299 1 gender gender NOUN dti-1408 299 2 and and CCONJ dti-1408 299 3 renal renal ADJ dti-1408 299 4 function function NOUN dti-1408 299 5 influence influence NOUN dti-1408 299 6 plasma plasma NOUN dti-1408 299 7 levels level NOUN dti-1408 299 8 of of ADP dti-1408 299 9 copeptin copeptin NOUN dti-1408 299 10 in in ADP dti-1408 299 11 healthy healthy ADJ dti-1408 299 12 individuals individual NOUN dti-1408 299 13 . . PUNCT dti-1408 300 1 clin clin PROPN dti-1408 300 2 sci sci PROPN dti-1408 300 3 . . PROPN dti-1408 300 4 2009 2009 NUM dti-1408 300 5 ; ; PUNCT dti-1408 300 6 116:257–263 116:257–263 NUM dti-1408 300 7 . . PUNCT dti-1408 300 8 http://www.la-press.com http://www.la-press.com X dti-1408 300 9 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN