id sid tid token lemma pos dti-1410 1 1 29drug 29drug NUM dti-1410 1 2 target target NOUN dti-1410 1 3 insights insight VERB dti-1410 1 4 2015:9 2015:9 PRON dti-1410 1 5 management management NOUN dti-1410 1 6 of of ADP dti-1410 1 7 diabetes diabetes NOUN dti-1410 1 8 associated associate VERB dti-1410 1 9 with with ADP dti-1410 1 10 nephrotic nephrotic ADJ dti-1410 1 11 syndrome syndrome NOUN dti-1410 1 12 : : PUNCT dti-1410 1 13 therapeutic therapeutic ADJ dti-1410 1 14 potential potential NOUN dti-1410 1 15 of of ADP dti-1410 1 16 dapagliflozin dapagliflozin NOUN dti-1410 1 17 for for ADP dti-1410 1 18 protracted protract VERB dti-1410 1 19 volume volume NOUN dti-1410 1 20 retention retention NOUN dti-1410 1 21 toshimi toshimi PROPN dti-1410 1 22 imai imai PROPN dti-1410 1 23 , , PUNCT dti-1410 1 24 tetsu tetsu PROPN dti-1410 1 25 akimoto akimoto PROPN dti-1410 1 26 , , PUNCT dti-1410 1 27 chiharu chiharu PROPN dti-1410 1 28 ito ito PROPN dti-1410 1 29 , , PUNCT dti-1410 1 30 takahiro takahiro PROPN dti-1410 1 31 masuda masuda PROPN dti-1410 1 32 and and CCONJ dti-1410 1 33 daisuke daisuke PROPN dti-1410 1 34 nagata nagata PROPN dti-1410 1 35 division division NOUN dti-1410 1 36 of of ADP dti-1410 1 37 nephrology nephrology NOUN dti-1410 1 38 , , PUNCT dti-1410 1 39 department department NOUN dti-1410 1 40 of of ADP dti-1410 1 41 internal internal ADJ dti-1410 1 42 medicine medicine NOUN dti-1410 1 43 , , PUNCT dti-1410 1 44 jichi jichi PROPN dti-1410 1 45 medical medical PROPN dti-1410 1 46 university university PROPN dti-1410 1 47 , , PUNCT dti-1410 1 48 shimotsuke shimotsuke NOUN dti-1410 1 49 - - PUNCT dti-1410 1 50 shi shi PROPN dti-1410 1 51 , , PUNCT dti-1410 1 52 tochigi tochigi PROPN dti-1410 1 53 , , PUNCT dti-1410 1 54 japan japan PROPN dti-1410 1 55 . . PUNCT dti-1410 2 1 abstr abstr PROPN dti-1410 2 2 act act PROPN dti-1410 2 3 : : PUNCT dti-1410 2 4 a a DET dti-1410 2 5 48 48 NUM dti-1410 2 6 - - PUNCT dti-1410 2 7 year year NOUN dti-1410 2 8 - - PUNCT dti-1410 2 9 old old ADJ dti-1410 2 10 female female NOUN dti-1410 2 11 was be AUX dti-1410 2 12 admitted admit VERB dti-1410 2 13 to to ADP dti-1410 2 14 our our PRON dti-1410 2 15 hospital hospital NOUN dti-1410 2 16 presenting present VERB dti-1410 2 17 with with ADP dti-1410 2 18 a a DET dti-1410 2 19 chief chief ADJ dti-1410 2 20 complaint complaint NOUN dti-1410 2 21 of of ADP dti-1410 2 22 progressive progressive ADJ dti-1410 2 23 swelling swell VERB dti-1410 2 24 because because SCONJ dti-1410 2 25 of of ADP dti-1410 2 26 diabetic diabetic ADJ dti-1410 2 27 nephrotic nephrotic ADJ dti-1410 2 28 syndrome syndrome NOUN dti-1410 2 29 . . PUNCT dti-1410 3 1 dapagliflozin dapagliflozin PROPN dti-1410 3 2 seemed seem VERB dti-1410 3 3 to to PART dti-1410 3 4 play play VERB dti-1410 3 5 a a DET dti-1410 3 6 role role NOUN dti-1410 3 7 in in ADP dti-1410 3 8 accelerating accelerate VERB dti-1410 3 9 the the DET dti-1410 3 10 patient patient NOUN dti-1410 3 11 ’s ’s PART dti-1410 3 12 urinary urinary ADJ dti-1410 3 13 sodium sodium NOUN dti-1410 3 14 excretion excretion NOUN dti-1410 3 15 as as ADV dti-1410 3 16 well well ADV dti-1410 3 17 as as ADP dti-1410 3 18 reducing reduce VERB dti-1410 3 19 gross gross ADJ dti-1410 3 20 fluid fluid ADJ dti-1410 3 21 retention retention NOUN dti-1410 3 22 despite despite SCONJ dti-1410 3 23 the the DET dti-1410 3 24 fact fact NOUN dti-1410 3 25 that that SCONJ dti-1410 3 26 her her PRON dti-1410 3 27 nephrotic nephrotic ADJ dti-1410 3 28 condition condition NOUN dti-1410 3 29 was be AUX dti-1410 3 30 resistant resistant ADJ dti-1410 3 31 to to PART dti-1410 3 32 furosemide furosemide VERB dti-1410 3 33 . . PUNCT dti-1410 4 1 our our PRON dti-1410 4 2 experience experience NOUN dti-1410 4 3 emphasizes emphasize VERB dti-1410 4 4 a a DET dti-1410 4 5 potential potential ADJ dti-1410 4 6 novel novel ADJ dti-1410 4 7 approach approach NOUN dti-1410 4 8 to to ADP dti-1410 4 9 overcoming overcome VERB dti-1410 4 10 loop loop NOUN dti-1410 4 11 diuretic diuretic ADJ dti-1410 4 12 resistance resistance NOUN dti-1410 4 13 using use VERB dti-1410 4 14 this this DET dti-1410 4 15 agent agent NOUN dti-1410 4 16 among among ADP dti-1410 4 17 some some DET dti-1410 4 18 subsets subset NOUN dti-1410 4 19 of of ADP dti-1410 4 20 type type NOUN dti-1410 4 21 2 2 NUM dti-1410 4 22 diabetic diabetic ADJ dti-1410 4 23 subjects subject NOUN dti-1410 4 24 complicated complicate VERB dti-1410 4 25 with with ADP dti-1410 4 26 severe severe ADJ dti-1410 4 27 volume volume NOUN dti-1410 4 28 accumulation accumulation NOUN dti-1410 4 29 . . PUNCT dti-1410 5 1 we we PRON dti-1410 5 2 believe believe VERB dti-1410 5 3 that that SCONJ dti-1410 5 4 combination combination NOUN dti-1410 5 5 treatment treatment NOUN dti-1410 5 6 consisting consist VERB dti-1410 5 7 of of ADP dti-1410 5 8 dapagliflozin dapagliflozin NOUN dti-1410 5 9 and and CCONJ dti-1410 5 10 furosemide furosemide ADV dti-1410 5 11 may may AUX dti-1410 5 12 produce produce VERB dti-1410 5 13 diuretic diuretic ADJ dti-1410 5 14 synergy synergy NOUN dti-1410 5 15 via via ADP dti-1410 5 16 sequential sequential ADJ dti-1410 5 17 nephron nephron NOUN dti-1410 5 18 blockade blockade NOUN dti-1410 5 19 . . PUNCT dti-1410 6 1 the the DET dti-1410 6 2 accumulation accumulation NOUN dti-1410 6 3 of of ADP dti-1410 6 4 more more ADJ dti-1410 6 5 experience experience NOUN dti-1410 6 6 with with ADP dti-1410 6 7 additional additional ADJ dti-1410 6 8 cases case NOUN dti-1410 6 9 similar similar ADJ dti-1410 6 10 to to ADP dti-1410 6 11 ours ours PRON dti-1410 6 12 requires require VERB dti-1410 6 13 continuous continuous ADJ dti-1410 6 14 and and CCONJ dti-1410 6 15 careful careful ADJ dti-1410 6 16 attention attention NOUN dti-1410 6 17 . . PUNCT dti-1410 7 1 key key ADJ dti-1410 7 2 words word NOUN dti-1410 7 3 : : PUNCT dti-1410 7 4 nephrotic nephrotic ADJ dti-1410 7 5 syndrome syndrome NOUN dti-1410 7 6 , , PUNCT dti-1410 7 7 sglt-2 sglt-2 NUM dti-1410 7 8 , , PUNCT dti-1410 7 9 dapagliflozin dapagliflozin NOUN dti-1410 7 10 , , PUNCT dti-1410 7 11 diabetes diabetes NOUN dti-1410 7 12 , , PUNCT dti-1410 7 13 furosemide furosemide ADJ dti-1410 7 14 citation citation NOUN dti-1410 7 15 : : PUNCT dti-1410 7 16 imai imai PROPN dti-1410 7 17 et et PROPN dti-1410 7 18 al al PROPN dti-1410 7 19 . . PUNCT dti-1410 7 20 management management NOUN dti-1410 7 21 of of ADP dti-1410 7 22 diabetes diabetes NOUN dti-1410 7 23 associated associate VERB dti-1410 7 24 with with ADP dti-1410 7 25 nephrotic nephrotic ADJ dti-1410 7 26 syndrome syndrome NOUN dti-1410 7 27 : : PUNCT dti-1410 7 28 therapeutic therapeutic ADJ dti-1410 7 29 potential potential NOUN dti-1410 7 30 of of ADP dti-1410 7 31 dapagliflozin dapagliflozin NOUN dti-1410 7 32 for for ADP dti-1410 7 33 protracted protract VERB dti-1410 7 34 volume volume NOUN dti-1410 7 35 retention retention NOUN dti-1410 7 36 . . PUNCT dti-1410 8 1 drug drug NOUN dti-1410 8 2 target target NOUN dti-1410 8 3 insights insight NOUN dti-1410 8 4 2015:9 2015:9 DET dti-1410 8 5 29–31 29–31 NUM dti-1410 8 6 doi:10.4137 doi:10.4137 NOUN dti-1410 8 7 / / SYM dti-1410 8 8 dti.s31710 dti.s31710 NOUN dti-1410 8 9 . . PUNCT dti-1410 9 1 type type NOUN dti-1410 9 2 : : PUNCT dti-1410 9 3 case case NOUN dti-1410 9 4 report report NOUN dti-1410 9 5 received receive VERB dti-1410 9 6 : : PUNCT dti-1410 9 7 july july PROPN dti-1410 9 8 13 13 NUM dti-1410 9 9 , , PUNCT dti-1410 9 10 2015 2015 NUM dti-1410 9 11 . . PUNCT dti-1410 10 1 resubmitted resubmitte VERB dti-1410 10 2 : : PUNCT dti-1410 10 3 september september PROPN dti-1410 10 4 10 10 NUM dti-1410 10 5 , , PUNCT dti-1410 10 6 2015 2015 NUM dti-1410 10 7 . . PUNCT dti-1410 11 1 accepted accept VERB dti-1410 11 2 for for ADP dti-1410 11 3 publication publication NOUN dti-1410 11 4 : : PUNCT dti-1410 11 5 september september PROPN dti-1410 11 6 14 14 NUM dti-1410 11 7 , , PUNCT dti-1410 11 8 2015 2015 NUM dti-1410 11 9 . . PUNCT dti-1410 12 1 academic academic ADJ dti-1410 12 2 editor editor NOUN dti-1410 12 3 : : PUNCT dti-1410 12 4 anuj anuj PROPN dti-1410 12 5 chauhan chauhan PROPN dti-1410 12 6 , , PUNCT dti-1410 12 7 editor editor NOUN dti-1410 12 8 in in ADP dti-1410 12 9 chief chief ADJ dti-1410 12 10 peer peer NOUN dti-1410 12 11 review review NOUN dti-1410 12 12 : : PUNCT dti-1410 12 13 three three NUM dti-1410 12 14 peer peer NOUN dti-1410 12 15 reviewers reviewer NOUN dti-1410 12 16 contributed contribute VERB dti-1410 12 17 to to ADP dti-1410 12 18 the the DET dti-1410 12 19 peer peer NOUN dti-1410 12 20 review review NOUN dti-1410 12 21 report report NOUN dti-1410 12 22 . . PUNCT dti-1410 13 1 reviewers reviewer NOUN dti-1410 13 2 ’ ' PUNCT dti-1410 13 3 reports report NOUN dti-1410 13 4 totaled total VERB dti-1410 13 5 358 358 NUM dti-1410 13 6 words word NOUN dti-1410 13 7 , , PUNCT dti-1410 13 8 excluding exclude VERB dti-1410 13 9 any any DET dti-1410 13 10 confidential confidential ADJ dti-1410 13 11 comments comment NOUN dti-1410 13 12 to to ADP dti-1410 13 13 the the DET dti-1410 13 14 academic academic ADJ dti-1410 13 15 editor editor NOUN dti-1410 13 16 . . PUNCT dti-1410 14 1 funding funding NOUN dti-1410 14 2 : : PUNCT dti-1410 14 3 authors author NOUN dti-1410 14 4 disclose disclose VERB dti-1410 14 5 no no DET dti-1410 14 6 funding funding NOUN dti-1410 14 7 sources source NOUN dti-1410 14 8 . . PUNCT dti-1410 15 1 competing compete VERB dti-1410 15 2 interests interest NOUN dti-1410 15 3 : : PUNCT dti-1410 15 4 authors author NOUN dti-1410 15 5 disclose disclose VERB dti-1410 15 6 no no DET dti-1410 15 7 potential potential ADJ dti-1410 15 8 conflicts conflict NOUN dti-1410 15 9 of of ADP dti-1410 15 10 interest interest NOUN dti-1410 15 11 . . PUNCT dti-1410 16 1 copyright copyright NOUN dti-1410 16 2 : : PUNCT dti-1410 16 3 © © PROPN dti-1410 16 4 the the DET dti-1410 16 5 authors author NOUN dti-1410 16 6 , , PUNCT dti-1410 16 7 publisher publisher NOUN dti-1410 16 8 and and CCONJ dti-1410 16 9 licensee licensee NOUN dti-1410 16 10 libertas liberta NOUN dti-1410 16 11 academica academica PROPN dti-1410 16 12 limited limit VERB dti-1410 16 13 . . PUNCT dti-1410 17 1 this this PRON dti-1410 17 2 is be AUX dti-1410 17 3 an an DET dti-1410 17 4 open open ADJ dti-1410 17 5 - - PUNCT dti-1410 17 6 access access NOUN dti-1410 17 7 article article NOUN dti-1410 17 8 distributed distribute VERB dti-1410 17 9 under under ADP dti-1410 17 10 the the DET dti-1410 17 11 terms term NOUN dti-1410 17 12 of of ADP dti-1410 17 13 the the DET dti-1410 17 14 creative creative ADJ dti-1410 17 15 commons common NOUN dti-1410 17 16 cc cc NOUN dti-1410 17 17 - - PUNCT dti-1410 17 18 by by ADP dti-1410 17 19 - - PUNCT dti-1410 17 20 nc nc PROPN dti-1410 17 21 3.0 3.0 NUM dti-1410 17 22 license license NOUN dti-1410 17 23 . . PUNCT dti-1410 18 1 correspondence correspondence NOUN dti-1410 18 2 : : PUNCT dti-1410 18 3 r0609ti@jichi.ac.jp r0609ti@jichi.ac.jp VERB dti-1410 18 4 paper paper NOUN dti-1410 18 5 subject subject NOUN dti-1410 18 6 to to ADP dti-1410 18 7 independent independent ADJ dti-1410 18 8 expert expert ADJ dti-1410 18 9 blind blind ADJ dti-1410 18 10 peer peer NOUN dti-1410 18 11 review review NOUN dti-1410 18 12 . . PUNCT dti-1410 19 1 all all DET dti-1410 19 2 editorial editorial ADJ dti-1410 19 3 decisions decision NOUN dti-1410 19 4 made make VERB dti-1410 19 5 by by ADP dti-1410 19 6 independent independent ADJ dti-1410 19 7 academic academic ADJ dti-1410 19 8 editor editor NOUN dti-1410 19 9 . . PUNCT dti-1410 20 1 upon upon SCONJ dti-1410 20 2 submission submission NOUN dti-1410 20 3 manuscript manuscript NOUN dti-1410 20 4 was be AUX dti-1410 20 5 subject subject ADJ dti-1410 20 6 to to ADP dti-1410 20 7 antiplagiarism antiplagiarism NOUN dti-1410 20 8 scanning scanning NOUN dti-1410 20 9 . . PUNCT dti-1410 21 1 prior prior ADV dti-1410 21 2 to to ADP dti-1410 21 3 publication publication NOUN dti-1410 21 4 all all DET dti-1410 21 5 authors author NOUN dti-1410 21 6 have have AUX dti-1410 21 7 given give VERB dti-1410 21 8 signed sign VERB dti-1410 21 9 confirmation confirmation NOUN dti-1410 21 10 of of ADP dti-1410 21 11 agreement agreement NOUN dti-1410 21 12 to to ADP dti-1410 21 13 article article NOUN dti-1410 21 14 publication publication NOUN dti-1410 21 15 and and CCONJ dti-1410 21 16 compliance compliance NOUN dti-1410 21 17 with with ADP dti-1410 21 18 all all DET dti-1410 21 19 applicable applicable ADJ dti-1410 21 20 ethical ethical ADJ dti-1410 21 21 and and CCONJ dti-1410 21 22 legal legal ADJ dti-1410 21 23 requirements requirement NOUN dti-1410 21 24 , , PUNCT dti-1410 21 25 including include VERB dti-1410 21 26 the the DET dti-1410 21 27 accuracy accuracy NOUN dti-1410 21 28 of of ADP dti-1410 21 29 author author NOUN dti-1410 21 30 and and CCONJ dti-1410 21 31 contributor contributor NOUN dti-1410 21 32 information information NOUN dti-1410 21 33 , , PUNCT dti-1410 21 34 disclosure disclosure NOUN dti-1410 21 35 of of ADP dti-1410 21 36 competing compete VERB dti-1410 21 37 interests interest NOUN dti-1410 21 38 and and CCONJ dti-1410 21 39 funding funding NOUN dti-1410 21 40 sources source NOUN dti-1410 21 41 , , PUNCT dti-1410 21 42 compliance compliance NOUN dti-1410 21 43 with with ADP dti-1410 21 44 ethical ethical ADJ dti-1410 21 45 requirements requirement NOUN dti-1410 21 46 relating relate VERB dti-1410 21 47 to to ADP dti-1410 21 48 human human ADJ dti-1410 21 49 and and CCONJ dti-1410 21 50 animal animal NOUN dti-1410 21 51 study study NOUN dti-1410 21 52 participants participant NOUN dti-1410 21 53 , , PUNCT dti-1410 21 54 and and CCONJ dti-1410 21 55 compliance compliance NOUN dti-1410 21 56 with with ADP dti-1410 21 57 any any DET dti-1410 21 58 copyright copyright NOUN dti-1410 21 59 requirements requirement NOUN dti-1410 21 60 of of ADP dti-1410 21 61 third third ADJ dti-1410 21 62 parties party NOUN dti-1410 21 63 . . PUNCT dti-1410 22 1 this this DET dti-1410 22 2 journal journal NOUN dti-1410 22 3 is be AUX dti-1410 22 4 a a DET dti-1410 22 5 member member NOUN dti-1410 22 6 of of ADP dti-1410 22 7 the the DET dti-1410 22 8 committee committee NOUN dti-1410 22 9 on on ADP dti-1410 22 10 publication publication NOUN dti-1410 22 11 ethics ethic NOUN dti-1410 22 12 ( ( PUNCT dti-1410 22 13 cope cope PROPN dti-1410 22 14 ) ) PUNCT dti-1410 22 15 . . PUNCT dti-1410 23 1 published publish VERB dti-1410 23 2 by by ADP dti-1410 23 3 libertas liberta NOUN dti-1410 23 4 academica academica PROPN dti-1410 23 5 . . PUNCT dti-1410 24 1 learn learn VERB dti-1410 24 2 more more ADJ dti-1410 24 3 about about ADP dti-1410 24 4 this this DET dti-1410 24 5 journal journal NOUN dti-1410 24 6 . . PUNCT dti-1410 25 1 introduction introduction NOUN dti-1410 25 2 dapagliflozin dapagliflozin PROPN dti-1410 25 3 , , PUNCT dti-1410 25 4 a a DET dti-1410 25 5 sodium sodium NOUN dti-1410 25 6 – – PUNCT dti-1410 25 7 glucose glucose NOUN dti-1410 25 8 cotransporter cotransporter NOUN dti-1410 25 9 2 2 NUM dti-1410 25 10 ( ( PUNCT dti-1410 25 11 sglt-2 sglt-2 NUM dti-1410 25 12 ) ) PUNCT dti-1410 25 13 inhibitor inhibitor NOUN dti-1410 25 14 , , PUNCT dti-1410 25 15 which which PRON dti-1410 25 16 recently recently ADV dti-1410 25 17 received receive VERB dti-1410 25 18 marketing marketing NOUN dti-1410 25 19 approval approval NOUN dti-1410 25 20 as as ADP dti-1410 25 21 a a DET dti-1410 25 22 novel novel ADJ dti-1410 25 23 therapeutic therapeutic ADJ dti-1410 25 24 option option NOUN dti-1410 25 25 for for ADP dti-1410 25 26 type type NOUN dti-1410 25 27 2 2 NUM dti-1410 25 28 diabetes diabetes NOUN dti-1410 25 29 , , PUNCT dti-1410 25 30 promotes promote VERB dti-1410 25 31 glycosuria glycosuria NOUN dti-1410 25 32 via via ADP dti-1410 25 33 an an DET dti-1410 25 34 osmotic osmotic ADJ dti-1410 25 35 diuretic diuretic ADJ dti-1410 25 36 effect.1 effect.1 NOUN dti-1410 25 37 in in ADP dti-1410 25 38 this this DET dti-1410 25 39 report report NOUN dti-1410 25 40 , , PUNCT dti-1410 25 41 we we PRON dti-1410 25 42 describe describe VERB dti-1410 25 43 our our PRON dti-1410 25 44 serendipitous serendipitous ADJ dti-1410 25 45 experience experience NOUN dti-1410 25 46 with with ADP dti-1410 25 47 a a DET dti-1410 25 48 case case NOUN dti-1410 25 49 of of ADP dti-1410 25 50 type type NOUN dti-1410 25 51 2 2 NUM dti-1410 25 52 diabetes diabetes NOUN dti-1410 25 53 accompanied accompany VERB dti-1410 25 54 by by ADP dti-1410 25 55 nephrotic nephrotic ADJ dti-1410 25 56 syndrome syndrome NOUN dti-1410 25 57 in in ADP dti-1410 25 58 which which PRON dti-1410 25 59 dapagliflozin dapagliflozin PROPN dti-1410 25 60 seemed seem VERB dti-1410 25 61 to to PART dti-1410 25 62 play play VERB dti-1410 25 63 a a DET dti-1410 25 64 role role NOUN dti-1410 25 65 in in ADP dti-1410 25 66 controlling control VERB dti-1410 25 67 diuretic diuretic ADJ dti-1410 25 68 - - PUNCT dti-1410 25 69 resistant resistant ADJ dti-1410 25 70 fluid fluid ADJ dti-1410 25 71 retention retention NOUN dti-1410 25 72 . . PUNCT dti-1410 26 1 case case NOUN dti-1410 26 2 report report VERB dti-1410 26 3 a a DET dti-1410 26 4 48 48 NUM dti-1410 26 5 - - PUNCT dti-1410 26 6 year year NOUN dti-1410 26 7 - - PUNCT dti-1410 26 8 old old ADJ dti-1410 26 9 female female NOUN dti-1410 26 10 was be AUX dti-1410 26 11 admitted admit VERB dti-1410 26 12 to to ADP dti-1410 26 13 our our PRON dti-1410 26 14 hospital hospital NOUN dti-1410 26 15 presenting present VERB dti-1410 26 16 with with ADP dti-1410 26 17 a a DET dti-1410 26 18 complaint complaint NOUN dti-1410 26 19 of of ADP dti-1410 26 20 progressive progressive ADJ dti-1410 26 21 swelling swelling NOUN dti-1410 26 22 of of ADP dti-1410 26 23 her her PRON dti-1410 26 24 legs leg NOUN dti-1410 26 25 . . PUNCT dti-1410 27 1 she she PRON dti-1410 27 2 had have AUX dti-1410 27 3 gained gain VERB dti-1410 27 4 ~20 ~20 NOUN dti-1410 27 5     SPACE dti-1410 27 6 kg kg NOUN dti-1410 27 7 in in ADP dti-1410 27 8 the the DET dti-1410 27 9 past past ADJ dti-1410 27 10 four four NUM dti-1410 27 11 months month NOUN dti-1410 27 12 . . PUNCT dti-1410 28 1 at at ADP dti-1410 28 2 35 35 NUM dti-1410 28 3 years year NOUN dti-1410 28 4 of of ADP dti-1410 28 5 age age NOUN dti-1410 28 6 , , PUNCT dti-1410 28 7 she she PRON dti-1410 28 8 was be AUX dti-1410 28 9 found find VERB dti-1410 28 10 to to PART dti-1410 28 11 have have VERB dti-1410 28 12 type type NOUN dti-1410 28 13 2 2 NUM dti-1410 28 14 diabetes diabetes NOUN dti-1410 28 15 with with ADP dti-1410 28 16 a a DET dti-1410 28 17 hemoglobin hemoglobin NOUN dti-1410 28 18 a1c a1c PROPN dti-1410 28 19 ( ( PUNCT dti-1410 28 20 hba1c hba1c ADJ dti-1410 28 21 ) ) PUNCT dti-1410 28 22 level level NOUN dti-1410 28 23 of of ADP dti-1410 28 24 9.4 9.4 NUM dti-1410 28 25 % % NOUN dti-1410 28 26 , , PUNCT dti-1410 28 27 for for ADP dti-1410 28 28 which which PRON dti-1410 28 29 she she PRON dti-1410 28 30 had have AUX dti-1410 28 31 received receive VERB dti-1410 28 32 sporadic sporadic ADJ dti-1410 28 33 medical medical ADJ dti-1410 28 34 care care NOUN dti-1410 28 35 . . PUNCT dti-1410 29 1 two two NUM dti-1410 29 2 months month NOUN dti-1410 29 3 before before ADP dti-1410 29 4 admission admission NOUN dti-1410 29 5 , , PUNCT dti-1410 29 6 when when SCONJ dti-1410 29 7 she she PRON dti-1410 29 8 was be AUX dti-1410 29 9 found find VERB dti-1410 29 10 to to PART dti-1410 29 11 have have VERB dti-1410 29 12 hypertension hypertension NOUN dti-1410 29 13 and and CCONJ dti-1410 29 14 hypercholesterolemia hypercholesterolemia NOUN dti-1410 29 15 as as ADV dti-1410 29 16 well well ADV dti-1410 29 17 as as ADP dti-1410 29 18 uncontrolled uncontrolled ADJ dti-1410 29 19 diabetes diabetes NOUN dti-1410 29 20 with with ADP dti-1410 29 21 a a DET dti-1410 29 22 serum serum NOUN dti-1410 29 23 hba1c hba1c NOUN dti-1410 29 24 level level NOUN dti-1410 29 25 of of ADP dti-1410 29 26 7.1 7.1 NUM dti-1410 29 27 % % NOUN dti-1410 29 28 , , PUNCT dti-1410 29 29 treatment treatment NOUN dti-1410 29 30 with with ADP dti-1410 29 31 furosemide furosemide NOUN dti-1410 29 32 at at ADP dti-1410 29 33 a a DET dti-1410 29 34 dose dose NOUN dti-1410 29 35 of of ADP dti-1410 29 36 60 60 NUM dti-1410 29 37     SPACE dti-1410 29 38 mg mg PROPN dti-1410 29 39 / / SYM dti-1410 29 40 day day NOUN dti-1410 29 41 combined combine VERB dti-1410 29 42 with with ADP dti-1410 29 43 alogliptin alogliptin NOUN dti-1410 29 44 at at ADP dti-1410 29 45 a a DET dti-1410 29 46 dose dose NOUN dti-1410 29 47 of of ADP dti-1410 29 48 25 25 NUM dti-1410 29 49     SPACE dti-1410 29 50 mg mg PROPN dti-1410 29 51 / / SYM dti-1410 29 52 day day NOUN dti-1410 29 53 , , PUNCT dti-1410 29 54 irbesartan irbesartan PROPN dti-1410 29 55 at at ADP dti-1410 29 56 a a DET dti-1410 29 57 dose dose NOUN dti-1410 29 58 of of ADP dti-1410 29 59 100 100 NUM dti-1410 29 60     SPACE dti-1410 29 61 mg mg PROPN dti-1410 29 62 / / SYM dti-1410 29 63 day day NOUN dti-1410 29 64 , , PUNCT dti-1410 29 65 amlodipine amlodipine NOUN dti-1410 29 66 at at ADP dti-1410 29 67 a a DET dti-1410 29 68 dose dose NOUN dti-1410 29 69 of of ADP dti-1410 29 70 10 10 NUM dti-1410 29 71     SPACE dti-1410 29 72 mg mg PROPN dti-1410 29 73 / / SYM dti-1410 29 74 day day NOUN dti-1410 29 75 , , PUNCT dti-1410 29 76 and and CCONJ dti-1410 29 77 rosuvastatin rosuvastatin NOUN dti-1410 29 78 at at ADP dti-1410 29 79 a a DET dti-1410 29 80 dose dose NOUN dti-1410 29 81 of of ADP dti-1410 29 82 2.5 2.5 NUM dti-1410 29 83     SPACE dti-1410 29 84 mg mg PROPN dti-1410 29 85 / / SYM dti-1410 29 86 day day NOUN dti-1410 29 87 was be AUX dti-1410 29 88 started start VERB dti-1410 29 89 ; ; PUNCT dti-1410 29 90 however however ADV dti-1410 29 91 , , PUNCT dti-1410 29 92 her her PRON dti-1410 29 93 generalized generalized ADJ dti-1410 29 94 edema edema NOUN dti-1410 29 95 persisted persist VERB dti-1410 29 96 and and CCONJ dti-1410 29 97 subsequently subsequently ADV dti-1410 29 98 worsened worsen VERB dti-1410 29 99 . . PUNCT dti-1410 30 1 therefore therefore ADV dti-1410 30 2 , , PUNCT dti-1410 30 3 she she PRON dti-1410 30 4 was be AUX dti-1410 30 5 referred refer VERB dti-1410 30 6 and and CCONJ dti-1410 30 7 admitted admit VERB dti-1410 30 8 for for ADP dti-1410 30 9 a a DET dti-1410 30 10 further further ADJ dti-1410 30 11 workup workup NOUN dti-1410 30 12 . . PUNCT dti-1410 31 1 she she PRON dti-1410 31 2 neither neither CCONJ dti-1410 31 3 smoked smoke VERB dti-1410 31 4 nor nor CCONJ dti-1410 31 5 drank drank VERB dti-1410 31 6 alcohol alcohol NOUN dti-1410 31 7 and and CCONJ dti-1410 31 8 denied deny VERB dti-1410 31 9 using use VERB dti-1410 31 10 any any DET dti-1410 31 11     SPACE dti-1410 31 12 drugs drug NOUN dti-1410 31 13 . . PUNCT dti-1410 32 1 a a DET dti-1410 32 2 physical physical ADJ dti-1410 32 3 examination examination NOUN dti-1410 32 4 completed complete VERB dti-1410 32 5 on on ADP dti-1410 32 6 admission admission NOUN dti-1410 32 7 revealed reveal VERB dti-1410 32 8 that that SCONJ dti-1410 32 9 the the DET dti-1410 32 10 patient patient NOUN dti-1410 32 11 ’s ’s PART dti-1410 32 12 face face NOUN dti-1410 32 13 was be AUX dti-1410 32 14 swollen swollen ADJ dti-1410 32 15 , , PUNCT dti-1410 32 16 with with ADP dti-1410 32 17 significant significant ADJ dti-1410 32 18 edema edema NOUN dti-1410 32 19 noted note VERB dti-1410 32 20 in in ADP dti-1410 32 21 the the DET dti-1410 32 22 upper upper ADJ dti-1410 32 23 and and CCONJ dti-1410 32 24 lower low ADJ dti-1410 32 25 extremities extremity NOUN dti-1410 32 26 . . PUNCT dti-1410 33 1 her her PRON dti-1410 33 2 blood blood NOUN dti-1410 33 3 pressure pressure NOUN dti-1410 33 4 ( ( PUNCT dti-1410 33 5 bp bp PROPN dti-1410 33 6 ) ) PUNCT dti-1410 33 7 was be AUX dti-1410 33 8 153/87 153/87 NUM dti-1410 33 9     SPACE dti-1410 33 10 mmhg mmhg NOUN dti-1410 33 11 , , PUNCT dti-1410 33 12 her her PRON dti-1410 33 13 pulse pulse NOUN dti-1410 33 14 was be AUX dti-1410 33 15 90 90 NUM dti-1410 33 16     SPACE dti-1410 33 17 beats beat NOUN dti-1410 33 18 / / SYM dti-1410 33 19 minute minute NOUN dti-1410 33 20 , , PUNCT dti-1410 33 21 and and CCONJ dti-1410 33 22 her her PRON dti-1410 33 23 temperature temperature NOUN dti-1410 33 24 was be AUX dti-1410 33 25 36.0 36.0 NUM dti-1410 33 26 ° ° NOUN dti-1410 33 27 c c NOUN dti-1410 33 28 . . PUNCT dti-1410 34 1 although although SCONJ dti-1410 34 2 the the DET dti-1410 34 3 oxygen oxygen NOUN dti-1410 34 4 saturation saturation NOUN dti-1410 34 5 was be AUX dti-1410 34 6 98 98 NUM dti-1410 34 7 % % NOUN dti-1410 34 8 while while SCONJ dti-1410 34 9 she she PRON dti-1410 34 10 breathed breathe VERB dti-1410 34 11 ambient ambient ADJ dti-1410 34 12 air air NOUN dti-1410 34 13 , , PUNCT dti-1410 34 14 the the DET dti-1410 34 15 presence presence NOUN dti-1410 34 16 of of ADP dti-1410 34 17 bilateral bilateral ADJ dti-1410 34 18 pleural pleural ADJ dti-1410 34 19 effusion effusion NOUN dti-1410 34 20 and and CCONJ dti-1410 34 21 ascites ascite NOUN dti-1410 34 22 was be AUX dti-1410 34 23 confirmed confirm VERB dti-1410 34 24 on on ADP dti-1410 34 25 chest chest NOUN dti-1410 34 26 x x NOUN dti-1410 34 27 - - NOUN dti-1410 34 28 ray ray NOUN dti-1410 34 29 and/or and/or CCONJ dti-1410 34 30 computed compute VERB dti-1410 34 31 tomography tomography NOUN dti-1410 34 32 scans scan NOUN dti-1410 34 33 . . PUNCT dti-1410 35 1 no no DET dti-1410 35 2 findings finding NOUN dti-1410 35 3 suggestive suggestive ADJ dti-1410 35 4 of of ADP dti-1410 35 5 heart heart NOUN dti-1410 35 6 failure failure NOUN dti-1410 35 7 were be AUX dti-1410 35 8 observed observe VERB dti-1410 35 9 on on ADP dti-1410 35 10 echocardiography echocardiography NOUN dti-1410 35 11 . . PUNCT dti-1410 36 1 a a DET dti-1410 36 2 laboratory laboratory NOUN dti-1410 36 3 evaluation evaluation NOUN dti-1410 36 4 revealed reveal VERB dti-1410 36 5 the the DET dti-1410 36 6 following follow VERB dti-1410 36 7 results result NOUN dti-1410 36 8 : : PUNCT dti-1410 36 9 hb hb NOUN dti-1410 36 10 , , PUNCT dti-1410 36 11 9.5 9.5 NUM dti-1410 36 12     SPACE dti-1410 36 13 g g PROPN dti-1410 36 14 / / SYM dti-1410 36 15 dl dl PROPN dti-1410 36 16 ; ; PUNCT dti-1410 36 17 platelet platelet NOUN dti-1410 36 18 count count NOUN dti-1410 36 19 , , PUNCT dti-1410 36 20 33.6 33.6 NUM dti-1410 36 21     SPACE dti-1410 36 22 × × NOUN dti-1410 36 23     SPACE dti-1410 36 24 104 104 NUM dti-1410 36 25 / / SYM dti-1410 36 26 μl μl NUM dti-1410 36 27 ; ; PUNCT dti-1410 36 28 total total ADJ dti-1410 36 29 protein protein NOUN dti-1410 36 30 , , PUNCT dti-1410 36 31 5.5 5.5 NUM dti-1410 36 32     SPACE dti-1410 36 33 g g PROPN dti-1410 36 34 / / SYM dti-1410 36 35 dl dl PROPN dti-1410 36 36 ; ; PUNCT dti-1410 36 37 serum serum NOUN dti-1410 36 38 albumin albumin NOUN dti-1410 36 39 , , PUNCT dti-1410 36 40 2.0 2.0 NUM dti-1410 36 41     SPACE dti-1410 36 42 g g PROPN dti-1410 36 43 / / SYM dti-1410 36 44 dl dl PROPN dti-1410 36 45 ; ; PUNCT dti-1410 36 46 blood blood NOUN dti-1410 36 47 urea urea NOUN dti-1410 36 48 nitrogen nitrogen NOUN dti-1410 36 49 , , PUNCT dti-1410 36 50 14.5 14.5 NUM dti-1410 36 51     SPACE dti-1410 36 52 mg mg PROPN dti-1410 36 53 / / SYM dti-1410 36 54 dl dl PROPN dti-1410 36 55 ; ; PUNCT dti-1410 36 56 creatinine creatinine NOUN dti-1410 36 57 ( ( PUNCT dti-1410 36 58 cr cr NOUN dti-1410 36 59 ) ) PUNCT dti-1410 36 60 , , PUNCT dti-1410 36 61 1.01 1.01 NUM dti-1410 36 62     SPACE dti-1410 36 63 mg mg PROPN dti-1410 36 64 / / SYM dti-1410 36 65 dl dl PROPN dti-1410 36 66 ; ; PUNCT dti-1410 36 67 sodium sodium NOUN dti-1410 36 68 , , PUNCT dti-1410 36 69 141 141 NUM dti-1410 36 70     SPACE dti-1410 36 71 mmol mmol NOUN dti-1410 36 72 / / SYM dti-1410 36 73 l l NOUN dti-1410 36 74 ; ; PUNCT dti-1410 36 75 potassium potassium NOUN dti-1410 36 76 , , PUNCT dti-1410 36 77 4.0 4.0 NUM dti-1410 36 78     SPACE dti-1410 36 79 mmol mmol NOUN dti-1410 36 80 / / SYM dti-1410 36 81 l l NOUN dti-1410 36 82 ; ; PUNCT dti-1410 36 83 chloride chloride NOUN dti-1410 36 84 , , PUNCT dti-1410 36 85 105.1 105.1 NUM dti-1410 36 86     SPACE dti-1410 36 87 mmol mmol NOUN dti-1410 36 88 / / SYM dti-1410 36 89 l l NOUN dti-1410 36 90 ; ; PUNCT dti-1410 36 91 aspartate aspartate NOUN dti-1410 36 92 aminotransferase aminotransferase NOUN dti-1410 36 93 , , PUNCT dti-1410 36 94 20 20 NUM dti-1410 36 95     SPACE dti-1410 36 96 u u NOUN dti-1410 36 97 / / SYM dti-1410 36 98 l l NOUN dti-1410 36 99 ; ; PUNCT dti-1410 36 100 alanine alanine NOUN dti-1410 36 101 aminotransferase aminotransferase NOUN dti-1410 36 102 , , PUNCT dti-1410 36 103 9 9 NUM dti-1410 36 104     SPACE dti-1410 36 105 u u NOUN dti-1410 36 106 / / SYM dti-1410 36 107 l l NOUN dti-1410 36 108 ; ; PUNCT dti-1410 36 109 fasting fast VERB dti-1410 36 110 plasma plasma NOUN dti-1410 36 111 glucose glucose NOUN dti-1410 36 112 , , PUNCT dti-1410 36 113 180 180 NUM dti-1410 36 114     SPACE dti-1410 36 115 mg mg PROPN dti-1410 36 116 / / SYM dti-1410 36 117 dl dl PROPN dti-1410 36 118 ; ; PUNCT dti-1410 36 119 hba1c hba1c PROPN dti-1410 36 120 , , PUNCT dti-1410 36 121 6.6 6.6 NUM dti-1410 36 122 % % NOUN dti-1410 36 123 ; ; PUNCT dti-1410 36 124 and and CCONJ dti-1410 36 125 c c X dti-1410 36 126 - - PUNCT dti-1410 36 127 reactive reactive ADJ dti-1410 36 128 protein protein NOUN dti-1410 36 129 , , PUNCT dti-1410 36 130 0.3 0.3 NUM dti-1410 36 131     SPACE dti-1410 36 132 mg mg PROPN dti-1410 36 133 / / SYM dti-1410 36 134 dl dl PROPN dti-1410 36 135 . . PUNCT dti-1410 37 1 the the DET dti-1410 37 2 patient patient NOUN dti-1410 37 3 ’s ’s PART dti-1410 37 4 urine urine NOUN dti-1410 37 5 contained contain VERB dti-1410 37 6 7.0 7.0 NUM dti-1410 37 7     SPACE dti-1410 37 8 g g NOUN dti-1410 37 9 of of ADP dti-1410 37 10 protein protein NOUN dti-1410 37 11 in in ADP dti-1410 37 12 a a DET dti-1410 37 13 24 24 NUM dti-1410 37 14 - - PUNCT dti-1410 37 15 hour hour NOUN dti-1410 37 16 specimen speciman NOUN dti-1410 37 17 , , PUNCT dti-1410 37 18 and and CCONJ dti-1410 37 19 the the DET dti-1410 37 20 sediment sediment NOUN dti-1410 37 21 contained contain VERB dti-1410 37 22 five five NUM dti-1410 37 23 to to PART dti-1410 37 24 nine nine NUM dti-1410 37 25 red red ADJ dti-1410 37 26 blood blood NOUN dti-1410 37 27 cells cell NOUN dti-1410 37 28 per per ADP dti-1410 37 29 high high ADJ dti-1410 37 30 - - PUNCT dti-1410 37 31 power power NOUN dti-1410 37 32 field field NOUN dti-1410 37 33 . . PUNCT dti-1410 38 1 the the DET dti-1410 38 2 cr cr PROPN dti-1410 38 3 clearance clearance NOUN dti-1410 38 4 was be AUX dti-1410 38 5 29.0 29.0 NUM dti-1410 38 6     SPACE dti-1410 38 7 ml ml NOUN dti-1410 38 8 / / SYM dti-1410 38 9 minute minute NOUN dti-1410 38 10 . . PUNCT dti-1410 39 1 an an DET dti-1410 39 2 ophthalmologic ophthalmologic ADJ dti-1410 39 3 analysis analysis NOUN dti-1410 39 4 revealed reveal VERB dti-1410 39 5 severe severe ADJ dti-1410 39 6 nonproliferative nonproliferative ADJ dti-1410 39 7 diabetic diabetic ADJ dti-1410 39 8 retinopathy retinopathy NOUN dti-1410 39 9 . . PUNCT dti-1410 40 1 based base VERB dti-1410 40 2 on on ADP dti-1410 40 3 the the DET dti-1410 40 4 clinical clinical ADJ dti-1410 40 5 picture picture NOUN dti-1410 40 6 and and CCONJ dti-1410 40 7 laboratory laboratory NOUN dti-1410 40 8 findings finding NOUN dti-1410 40 9 , , PUNCT dti-1410 40 10 the the DET dti-1410 40 11 patient patient NOUN dti-1410 40 12 was be AUX dti-1410 40 13 thus thus ADV dti-1410 40 14 diagnosed diagnose VERB dti-1410 40 15 as as ADP dti-1410 40 16 having have VERB dti-1410 40 17 nephrotic nephrotic ADJ dti-1410 40 18 syndrome syndrome NOUN dti-1410 40 19 due due ADP dti-1410 40 20 to to ADP dti-1410 40 21 diabetic diabetic ADJ dti-1410 40 22 nephropathy nephropathy NOUN dti-1410 40 23 . . PUNCT dti-1410 41 1 despite despite SCONJ dti-1410 41 2 treatment treatment NOUN dti-1410 41 3 with with ADP dti-1410 41 4 an an DET dti-1410 41 5 increased increase VERB dti-1410 41 6 dose dose NOUN dti-1410 41 7 of of ADP dti-1410 41 8 furosemide furosemide NOUN dti-1410 41 9 , , PUNCT dti-1410 41 10 given give VERB dti-1410 41 11 both both CCONJ dti-1410 41 12 orally orally ADV dti-1410 41 13 and and CCONJ dti-1410 41 14 intravenously intravenously ADV dti-1410 41 15 , , PUNCT dti-1410 41 16 her her PRON dti-1410 41 17 body body NOUN dti-1410 41 18 weight weight NOUN dti-1410 41 19 and and CCONJ dti-1410 41 20 daily daily ADJ dti-1410 41 21 urine urine NOUN dti-1410 41 22 volume volume NOUN dti-1410 41 23 remained remain VERB dti-1410 41 24 almost almost ADV dti-1410 41 25 constant constant ADJ dti-1410 41 26 , , PUNCT dti-1410 41 27 keeping keep VERB dti-1410 41 28 her she PRON dti-1410 41 29 grossly grossly ADV dti-1410 41 30 edematous edematous ADJ dti-1410 41 31 . . PUNCT dti-1410 42 1 she she PRON dti-1410 42 2 then then ADV dti-1410 42 3 received receive VERB dti-1410 42 4 journal journal NOUN dti-1410 42 5 name name NOUN dti-1410 42 6 : : PUNCT dti-1410 42 7 drug drug NOUN dti-1410 42 8 target target NOUN dti-1410 42 9 insights insight NOUN dti-1410 42 10 journal journal NOUN dti-1410 42 11 type type NOUN dti-1410 42 12 : : PUNCT dti-1410 42 13 case case NOUN dti-1410 42 14 report report NOUN dti-1410 42 15 year year NOUN dti-1410 42 16 : : PUNCT dti-1410 42 17 2015 2015 NUM dti-1410 42 18 volume volume NOUN dti-1410 42 19 : : PUNCT dti-1410 42 20 9 9 NUM dti-1410 42 21 running run VERB dti-1410 42 22 head head NOUN dti-1410 42 23 verso verso NOUN dti-1410 42 24 : : PUNCT dti-1410 42 25 imai imai PROPN dti-1410 42 26 et et PROPN dti-1410 42 27 al al PROPN dti-1410 42 28 running run VERB dti-1410 42 29 head head NOUN dti-1410 42 30 recto recto NOUN dti-1410 42 31 : : PUNCT dti-1410 42 32 management management NOUN dti-1410 42 33 of of ADP dti-1410 42 34 diabetes diabetes NOUN dti-1410 42 35 associated associate VERB dti-1410 42 36 with with ADP dti-1410 42 37 nephrotic nephrotic ADJ dti-1410 42 38 syndrome syndrome NOUN dti-1410 42 39 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1410 42 40 http://www.la-press.com http://www.la-press.com X dti-1410 43 1 http://dx.doi.org/10.4137/dti.s31710 http://dx.doi.org/10.4137/dti.s31710 ADJ dti-1410 43 2 http://creativecommons.org/licenses/by-nc/3.0/ http://creativecommons.org/licenses/by-nc/3.0/ NOUN dti-1410 43 3 http://creativecommons.org/licenses/by-nc/3.0/ http://creativecommons.org/licenses/by-nc/3.0/ NOUN dti-1410 43 4 mailto:r0609ti@jichi.ac.jp mailto:r0609ti@jichi.ac.jp PROPN dti-1410 43 5 http://www.la-press.com http://www.la-press.com X dti-1410 43 6 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1410 43 7 imai imai PROPN dti-1410 43 8 et et PROPN dti-1410 43 9 al al PROPN dti-1410 43 10 30 30 NUM dti-1410 43 11 drug drug NOUN dti-1410 43 12 target target NOUN dti-1410 43 13 insights insight NOUN dti-1410 43 14 2015:9 2015:9 PRON dti-1410 43 15 treatment treatment NOUN dti-1410 43 16 with with ADP dti-1410 43 17 oral oral ADJ dti-1410 43 18 dapagliflozin dapagliflozin NOUN dti-1410 43 19 at at ADP dti-1410 43 20 a a DET dti-1410 43 21 dose dose NOUN dti-1410 43 22 of of ADP dti-1410 43 23 5 5 NUM dti-1410 43 24     SPACE dti-1410 43 25 mg mg PROPN dti-1410 43 26 / / SYM dti-1410 43 27 day day NOUN dti-1410 43 28 on on ADP dti-1410 43 29 hospital hospital NOUN dti-1410 43 30 day day NOUN dti-1410 43 31     SPACE dti-1410 43 32 5 5 NUM dti-1410 43 33 , , PUNCT dti-1410 43 34 which which PRON dti-1410 43 35 resulted result VERB dti-1410 43 36 in in ADP dti-1410 43 37 a a DET dti-1410 43 38 remarkable remarkable ADJ dti-1410 43 39 increase increase NOUN dti-1410 43 40 in in ADP dti-1410 43 41 her her PRON dti-1410 43 42 urine urine NOUN dti-1410 43 43 volume volume NOUN dti-1410 43 44 as as ADV dti-1410 43 45 well well ADV dti-1410 43 46 as as ADP dti-1410 43 47 the the DET dti-1410 43 48 amount amount NOUN dti-1410 43 49 of of ADP dti-1410 43 50 urinary urinary ADJ dti-1410 43 51 excreted excrete VERB dti-1410 43 52 sodium sodium NOUN dti-1410 43 53 and and CCONJ dti-1410 43 54 glucose glucose NOUN dti-1410 43 55 , , PUNCT dti-1410 43 56 with with ADP dti-1410 43 57 the the DET dti-1410 43 58 gradual gradual ADJ dti-1410 43 59 disappearance disappearance NOUN dti-1410 43 60 of of ADP dti-1410 43 61 the the DET dti-1410 43 62 generalized generalized ADJ dti-1410 43 63 edema edema NOUN dti-1410 43 64 , , PUNCT dti-1410 43 65 despite despite SCONJ dti-1410 43 66 the the DET dti-1410 43 67 almost almost ADV dti-1410 43 68 constant constant ADJ dti-1410 43 69 levels level NOUN dti-1410 43 70 of of ADP dti-1410 43 71 her her PRON dti-1410 43 72 systolic systolic ADJ dti-1410 43 73 and and CCONJ dti-1410 43 74 diastolic diastolic ADJ dti-1410 43 75 bp bp PROPN dti-1410 43 76 during during ADP dti-1410 43 77 the the DET dti-1410 43 78 observation observation NOUN dti-1410 43 79 period period NOUN dti-1410 43 80 ( ( PUNCT dti-1410 43 81 fig fig NOUN dti-1410 43 82 . . PUNCT dti-1410 43 83     SPACE dti-1410 43 84 1 1 NUM dti-1410 43 85 ) ) PUNCT dti-1410 43 86 . . PUNCT dti-1410 44 1 finally finally ADV dti-1410 44 2 , , PUNCT dti-1410 44 3 her her PRON dti-1410 44 4 body body NOUN dti-1410 44 5 weight weight NOUN dti-1410 44 6 settled settle VERB dti-1410 44 7 at at ADP dti-1410 44 8 around around ADV dti-1410 44 9 65 65 NUM dti-1410 44 10     SPACE dti-1410 44 11 kg kg NOUN dti-1410 44 12 under under ADP dti-1410 44 13 the the DET dti-1410 44 14 treatment treatment NOUN dti-1410 44 15 with with ADP dti-1410 44 16 sodium sodium NOUN dti-1410 44 17 and and CCONJ dti-1410 44 18 fluid fluid ADJ dti-1410 44 19 restriction restriction NOUN dti-1410 44 20 and and CCONJ dti-1410 44 21 the the DET dti-1410 44 22 same same ADJ dti-1410 44 23 dose dose NOUN dti-1410 44 24 of of ADP dti-1410 44 25 dapagliflozin dapagliflozin NOUN dti-1410 44 26 combined combine VERB dti-1410 44 27 with with ADP dti-1410 44 28 oral oral ADJ dti-1410 44 29 furosemide furosemide NOUN dti-1410 44 30 ( ( PUNCT dti-1410 44 31 220 220 NUM dti-1410 44 32     SPACE dti-1410 44 33 mg mg PROPN dti-1410 44 34 / / SYM dti-1410 44 35 day day NOUN dti-1410 44 36 ) ) PUNCT dti-1410 44 37 . . PUNCT dti-1410 45 1 at at ADP dti-1410 45 2 three three NUM dti-1410 45 3 months month NOUN dti-1410 45 4 of of ADP dti-1410 45 5 follow follow NOUN dti-1410 45 6 - - PUNCT dti-1410 45 7 up up NOUN dti-1410 45 8 , , PUNCT dti-1410 45 9 she she PRON dti-1410 45 10 is be AUX dti-1410 45 11 currently currently ADV dti-1410 45 12 doing do VERB dti-1410 45 13 well well ADV dti-1410 45 14 with with ADP dti-1410 45 15 an an DET dti-1410 45 16 hba1c hba1c ADJ dti-1410 45 17 level level NOUN dti-1410 45 18 of of ADP dti-1410 45 19 6.1 6.1 NUM dti-1410 45 20 % % NOUN dti-1410 45 21 despite despite SCONJ dti-1410 45 22 protracted protract VERB dti-1410 45 23 nephrotic nephrotic ADJ dti-1410 45 24 - - PUNCT dti-1410 45 25 range range NOUN dti-1410 45 26 proteinuria proteinuria NOUN dti-1410 45 27 at at ADP dti-1410 45 28 approximately approximately ADV dti-1410 45 29 5 5 NUM dti-1410 45 30     SPACE dti-1410 45 31 g g NOUN dti-1410 45 32 / / SYM dti-1410 45 33 day day NOUN dti-1410 45 34 . . PUNCT dti-1410 46 1 discussion discussion NOUN dti-1410 46 2 nephrologists nephrologist NOUN dti-1410 46 3 occasionally occasionally ADV dti-1410 46 4 face face VERB dti-1410 46 5 difficulties difficulty NOUN dti-1410 46 6 in in ADP dti-1410 46 7 controlling control VERB dti-1410 46 8 fluid fluid ADJ dti-1410 46 9 retention retention NOUN dti-1410 46 10 despite despite SCONJ dti-1410 46 11 the the DET dti-1410 46 12 availability availability NOUN dti-1410 46 13 of of ADP dti-1410 46 14 various various ADJ dti-1410 46 15 types type NOUN dti-1410 46 16 of of ADP dti-1410 46 17 diuretic diuretic ADJ dti-1410 46 18 agents.2,3 agents.2,3 PROPN dti-1410 46 19 the the DET dti-1410 46 20 pathogenic pathogenic ADJ dti-1410 46 21 processes process NOUN dti-1410 46 22 responsible responsible ADJ dti-1410 46 23 for for ADP dti-1410 46 24 diuretic diuretic ADJ dti-1410 46 25 resistance resistance NOUN dti-1410 46 26 are be AUX dti-1410 46 27 multifactorial multifactorial ADJ dti-1410 46 28 , , PUNCT dti-1410 46 29 and and CCONJ dti-1410 46 30 the the DET dti-1410 46 31 albumin albumin ADJ dti-1410 46 32 present present NOUN dti-1410 46 33 in in ADP dti-1410 46 34 the the DET dti-1410 46 35 luminal luminal ADJ dti-1410 46 36 content content NOUN dti-1410 46 37 as as ADP dti-1410 46 38 a a DET dti-1410 46 39 result result NOUN dti-1410 46 40 of of ADP dti-1410 46 41 the the DET dti-1410 46 42 disease disease NOUN dti-1410 46 43 process process NOUN dti-1410 46 44 is be AUX dti-1410 46 45 capable capable ADJ dti-1410 46 46 of of ADP dti-1410 46 47 binding bind VERB dti-1410 46 48 the the DET dti-1410 46 49 diuretic diuretic ADJ dti-1410 46 50 drug drug NOUN dti-1410 46 51 and and CCONJ dti-1410 46 52 thereby thereby ADV dti-1410 46 53 eliciting elicit VERB dti-1410 46 54 resistance resistance NOUN dti-1410 46 55 in in ADP dti-1410 46 56 subjects subject NOUN dti-1410 46 57 with with ADP dti-1410 46 58 nephrotic nephrotic ADJ dti-1410 46 59 syndrome.4 syndrome.4 NOUN dti-1410 46 60 consequently consequently ADV dti-1410 46 61 , , PUNCT dti-1410 46 62 one one PRON dti-1410 46 63 may may AUX dti-1410 46 64 argue argue VERB dti-1410 46 65 that that SCONJ dti-1410 46 66 some some PRON dti-1410 46 67 of of ADP dti-1410 46 68 the the DET dti-1410 46 69 clinical clinical ADJ dti-1410 46 70 manifestations manifestation NOUN dti-1410 46 71 and and CCONJ dti-1410 46 72 therapeutic therapeutic ADJ dti-1410 46 73 conundrums conundrum NOUN dti-1410 46 74 observed observe VERB dti-1410 46 75 in in ADP dti-1410 46 76 our our PRON dti-1410 46 77 patient patient NOUN dti-1410 46 78 are be AUX dti-1410 46 79 too too ADV dti-1410 46 80 common common ADJ dti-1410 46 81 to to PART dti-1410 46 82 be be AUX dti-1410 46 83 described describe VERB dti-1410 46 84 in in ADP dti-1410 46 85 the the DET dti-1410 46 86 literature literature NOUN dti-1410 46 87 ; ; PUNCT dti-1410 46 88 however however ADV dti-1410 46 89 , , PUNCT dti-1410 46 90 the the DET dti-1410 46 91 clinical clinical ADJ dti-1410 46 92 significance significance NOUN dti-1410 46 93 of of ADP dti-1410 46 94 the the DET dti-1410 46 95 current current ADJ dti-1410 46 96 report report NOUN dti-1410 46 97 should should AUX dti-1410 46 98 be be AUX dti-1410 46 99 evaluated evaluate VERB dti-1410 46 100 carefully carefully ADV dti-1410 46 101 in in ADP dti-1410 46 102 terms term NOUN dti-1410 46 103 of of ADP dti-1410 46 104 assessing assess VERB dti-1410 46 105 the the DET dti-1410 46 106 therapeutic therapeutic ADJ dti-1410 46 107 potential potential NOUN dti-1410 46 108 of of ADP dti-1410 46 109 dapagliflozin dapagliflozin NOUN dti-1410 46 110 for for ADP dti-1410 46 111 the the DET dti-1410 46 112 management management NOUN dti-1410 46 113 of of ADP dti-1410 46 114 refractory refractory NOUN dti-1410 46 115 edema edema NOUN dti-1410 46 116 in in ADP dti-1410 46 117 the the DET dti-1410 46 118 cases case NOUN dti-1410 46 119 of of ADP dti-1410 46 120 diabetic diabetic ADJ dti-1410 46 121 nephrotic nephrotic ADJ dti-1410 46 122 syndrome syndrome NOUN dti-1410 46 123 . . PUNCT dti-1410 47 1 comprehensive comprehensive ADJ dti-1410 47 2 insight insight NOUN dti-1410 47 3 into into ADP dti-1410 47 4 the the DET dti-1410 47 5 role role NOUN dti-1410 47 6 of of ADP dti-1410 47 7 sglt-2 sglt-2 NOUN dti-1410 47 8 , , PUNCT dti-1410 47 9 which which PRON dti-1410 47 10 is be AUX dti-1410 47 11 located locate VERB dti-1410 47 12 mainly mainly ADV dti-1410 47 13 in in ADP dti-1410 47 14 the the DET dti-1410 47 15 brush brush NOUN dti-1410 47 16 border border NOUN dti-1410 47 17 membrane membrane NOUN dti-1410 47 18 of of ADP dti-1410 47 19 the the DET dti-1410 47 20 early early ADJ dti-1410 47 21 proximal proximal ADJ dti-1410 47 22 tubule,5 tubule,5 NOUN dti-1410 47 23 in in ADP dti-1410 47 24 glucose glucose NOUN dti-1410 47 25 handling handling NOUN dti-1410 47 26 within within ADP dti-1410 47 27 the the DET dti-1410 47 28 kidney kidney NOUN dti-1410 47 29 has have AUX dti-1410 47 30 led lead VERB dti-1410 47 31 to to ADP dti-1410 47 32 the the DET dti-1410 47 33 development development NOUN dti-1410 47 34 of of ADP dti-1410 47 35 selective selective ADJ dti-1410 47 36 orally orally ADV dti-1410 47 37 available available ADJ dti-1410 47 38 sodium sodium NOUN dti-1410 47 39 – – PUNCT dti-1410 47 40 glucose glucose NOUN dti-1410 47 41 transport transport NOUN dti-1410 47 42 inhibitors inhibitor NOUN dti-1410 47 43 as as ADP dti-1410 47 44 a a DET dti-1410 47 45 means means NOUN dti-1410 47 46 of of ADP dti-1410 47 47 regulating regulate VERB dti-1410 47 48 the the DET dti-1410 47 49 serum serum NOUN dti-1410 47 50 glucose glucose NOUN dti-1410 47 51 level.1,6 level.1,6 PROPN dti-1410 47 52 recent recent ADJ dti-1410 47 53 clinical clinical ADJ dti-1410 47 54 trials trial NOUN dti-1410 47 55 of of ADP dti-1410 47 56 these these DET dti-1410 47 57 agents agent NOUN dti-1410 47 58 have have AUX dti-1410 47 59 demonstrated demonstrate VERB dti-1410 47 60 favorable favorable ADJ dti-1410 47 61 safety safety NOUN dti-1410 47 62 profiles profile NOUN dti-1410 47 63 , , PUNCT dti-1410 47 64 whereas whereas SCONJ dti-1410 47 65 neither neither CCONJ dti-1410 47 66 major major ADJ dti-1410 47 67 hypoglycemic hypoglycemic ADJ dti-1410 47 68 events event NOUN dti-1410 47 69 nor nor CCONJ dti-1410 47 70 adverse adverse ADJ dti-1410 47 71 changes change NOUN dti-1410 47 72 in in ADP dti-1410 47 73 the the DET dti-1410 47 74 renal renal ADJ dti-1410 47 75 function function NOUN dti-1410 47 76 were be AUX dti-1410 47 77 reported.7,8 reported.7,8 PROPN dti-1410 47 78 on on ADP dti-1410 47 79 the the DET dti-1410 47 80 other other ADJ dti-1410 47 81 hand hand NOUN dti-1410 47 82 , , PUNCT dti-1410 47 83 there there PRON dti-1410 47 84 are be VERB dti-1410 47 85 several several ADJ dti-1410 47 86 observations observation NOUN dti-1410 47 87 suggesting suggest VERB dti-1410 47 88 that that SCONJ dti-1410 47 89 the the DET dti-1410 47 90 promising promising ADJ dti-1410 47 91 benefits benefit NOUN dti-1410 47 92 of of ADP dti-1410 47 93 these these DET dti-1410 47 94 drugs drug NOUN dti-1410 47 95 may may AUX dti-1410 47 96 extend extend VERB dti-1410 47 97 beyond beyond ADP dti-1410 47 98 glycemic glycemic ADJ dti-1410 47 99 control control NOUN dti-1410 47 100 . . PUNCT dti-1410 48 1 the the DET dti-1410 48 2 blockade blockade NOUN dti-1410 48 3 of of ADP dti-1410 48 4 sglt-2 sglt-2 PROPN dti-1410 48 5 has have AUX dti-1410 48 6 been be AUX dti-1410 48 7 shown show VERB dti-1410 48 8 to to PART dti-1410 48 9 result result VERB dti-1410 48 10 in in ADP dti-1410 48 11 glycosuria glycosuria NOUN dti-1410 48 12 - - PUNCT dti-1410 48 13 mediated mediate VERB dti-1410 48 14 calorie calorie NOUN dti-1410 48 15 wasting wasting NOUN dti-1410 48 16 , , PUNCT dti-1410 48 17 leading lead VERB dti-1410 48 18 to to ADP dti-1410 48 19 weight weight NOUN dti-1410 48 20 loss.7 loss.7 NOUN dti-1410 48 21 such such ADJ dti-1410 48 22 treatment treatment NOUN dti-1410 48 23 may may AUX dti-1410 48 24 also also ADV dti-1410 48 25 lead lead VERB dti-1410 48 26 to to ADP dti-1410 48 27 reduced reduce VERB dti-1410 48 28 sodium sodium NOUN dti-1410 48 29 reabsorption reabsorption NOUN dti-1410 48 30 in in ADP dti-1410 48 31 the the DET dti-1410 48 32 proximal proximal ADJ dti-1410 48 33 tubule tubule NOUN dti-1410 48 34 , , PUNCT dti-1410 48 35 thereby thereby ADV dti-1410 48 36 accelerating accelerate VERB dti-1410 48 37 sodium sodium NOUN dti-1410 48 38 excretion.9 excretion.9 NOUN dti-1410 48 39 although although SCONJ dti-1410 48 40 too too ADV dti-1410 48 41 few few ADJ dti-1410 48 42 studies study NOUN dti-1410 48 43 have have AUX dti-1410 48 44 reported report VERB dti-1410 48 45 the the DET dti-1410 48 46 cases case NOUN dti-1410 48 47 of of ADP dti-1410 48 48 urinary urinary ADJ dti-1410 48 49 sodium sodium NOUN dti-1410 48 50 excretion excretion NOUN dti-1410 48 51 to to PART dti-1410 48 52 allow allow VERB dti-1410 48 53 for for ADP dti-1410 48 54 a a DET dti-1410 48 55 substantial substantial ADJ dti-1410 48 56 analysis,10–12 analysis,10–12 NOUN dti-1410 48 57 the the DET dti-1410 48 58 association association NOUN dti-1410 48 59 between between ADP dti-1410 48 60 the the DET dti-1410 48 61 use use NOUN dti-1410 48 62 of of ADP dti-1410 48 63 sglt-2 sglt-2 NUM dti-1410 48 64 inhibitors inhibitor NOUN dti-1410 48 65 and and CCONJ dti-1410 48 66 the the DET dti-1410 48 67 significant significant ADJ dti-1410 48 68 decreases decrease NOUN dti-1410 48 69 in in ADP dti-1410 48 70 bp bp PROPN dti-1410 48 71 demonstrated demonstrate VERB dti-1410 48 72 in in ADP dti-1410 48 73 several several ADJ dti-1410 48 74 recent recent ADJ dti-1410 48 75 studies study NOUN dti-1410 48 76 should should AUX dti-1410 48 77 encourage encourage VERB dti-1410 48 78 researchers researcher NOUN dti-1410 48 79 to to PART dti-1410 48 80 pursue pursue VERB dti-1410 48 81 further further ADJ dti-1410 48 82 investigations investigation NOUN dti-1410 48 83 regarding regard VERB dti-1410 48 84 the the DET dti-1410 48 85 diuretic diuretic ADJ dti-1410 48 86 - - PUNCT dti-1410 48 87 like like ADJ dti-1410 48 88 figure figure NOUN dti-1410 48 89 1 1 NUM dti-1410 48 90 . . PUNCT dti-1410 49 1 clinical clinical ADJ dti-1410 49 2 course course NOUN dti-1410 49 3 . . PUNCT dti-1410 50 1 on on ADP dti-1410 50 2 hospital hospital NOUN dti-1410 50 3 day day NOUN dti-1410 50 4 12 12 NUM dti-1410 50 5 , , PUNCT dti-1410 50 6 intravenous intravenous ADJ dti-1410 50 7 furosemide furosemide NOUN dti-1410 50 8 was be AUX dti-1410 50 9 terminated terminate VERB dti-1410 50 10 , , PUNCT dti-1410 50 11 while while SCONJ dti-1410 50 12 oral oral ADJ dti-1410 50 13 furosemide furosemide NOUN dti-1410 50 14 was be AUX dti-1410 50 15 continued continue VERB dti-1410 50 16 with with ADP dti-1410 50 17 an an DET dti-1410 50 18 increased increase VERB dti-1410 50 19 dose dose NOUN dti-1410 50 20 of of ADP dti-1410 50 21 300 300 NUM dti-1410 50 22 mg mg NUM dti-1410 50 23 / / SYM dti-1410 50 24 day day NOUN dti-1410 50 25 , , PUNCT dti-1410 50 26 and and CCONJ dti-1410 50 27 the the DET dti-1410 50 28 patient patient NOUN dti-1410 50 29 was be AUX dti-1410 50 30 discharged discharge VERB dti-1410 50 31 on on ADP dti-1410 50 32 hospital hospital NOUN dti-1410 50 33 day day NOUN dti-1410 50 34 16 16 NUM dti-1410 50 35 . . PUNCT dti-1410 51 1 note note VERB dti-1410 51 2 that that SCONJ dti-1410 51 3 the the DET dti-1410 51 4 levels level NOUN dti-1410 51 5 of of ADP dti-1410 51 6 bp bp PROPN dti-1410 51 7 and and CCONJ dti-1410 51 8 serum serum PROPN dti-1410 51 9 cr cr PROPN dti-1410 51 10 ( ( PUNCT dti-1410 51 11 scr scr NOUN dti-1410 51 12 ) ) PUNCT dti-1410 51 13 were be AUX dti-1410 51 14 almost almost ADV dti-1410 51 15 constant constant ADJ dti-1410 51 16 during during ADP dti-1410 51 17 the the DET dti-1410 51 18 observation observation NOUN dti-1410 51 19 period period NOUN dti-1410 51 20 despite despite SCONJ dti-1410 51 21 prominent prominent ADJ dti-1410 51 22 elevation elevation NOUN dti-1410 51 23 of of ADP dti-1410 51 24 the the DET dti-1410 51 25 daily daily ADJ dti-1410 51 26 urine urine NOUN dti-1410 51 27 output output NOUN dti-1410 51 28 after after ADP dti-1410 51 29 the the DET dti-1410 51 30 commencement commencement NOUN dti-1410 51 31 of of ADP dti-1410 51 32 oral oral ADJ dti-1410 51 33 dapagliflozin dapagliflozin NOUN dti-1410 51 34 . . PUNCT dti-1410 52 1 http://www.la-press.com http://www.la-press.com X dti-1410 53 1 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1410 53 2 management management NOUN dti-1410 53 3 of of ADP dti-1410 53 4 diabetes diabetes NOUN dti-1410 53 5 associated associate VERB dti-1410 53 6 with with ADP dti-1410 53 7 nephrotic nephrotic ADJ dti-1410 53 8 syndrome syndrome NOUN dti-1410 53 9 31drug 31drug NUM dti-1410 53 10 target target NOUN dti-1410 53 11 insights insight NOUN dti-1410 53 12 2015:9 2015:9 PRON dti-1410 53 13 antihypertensive antihypertensive ADJ dti-1410 53 14 actions action NOUN dti-1410 53 15 of of ADP dti-1410 53 16 these these DET dti-1410 53 17 medications medication NOUN dti-1410 53 18 , , PUNCT dti-1410 53 19 which which PRON dti-1410 53 20 should should AUX dti-1410 53 21 be be AUX dti-1410 53 22 linked link VERB dti-1410 53 23 to to ADP dti-1410 53 24 natriuresis natriuresis NOUN dti-1410 53 25 as as ADV dti-1410 53 26 well well ADV dti-1410 53 27 as as ADP dti-1410 53 28 glucose glucose NOUN dti-1410 53 29 - - PUNCT dti-1410 53 30 mediated mediate VERB dti-1410 53 31 osmotic osmotic ADJ dti-1410 53 32 diuresis.1,9,13 diuresis.1,9,13 NOUN dti-1410 53 33 at at ADP dti-1410 53 34 present present ADJ dti-1410 53 35 , , PUNCT dti-1410 53 36 we we PRON dti-1410 53 37 have have VERB dti-1410 53 38 no no DET dti-1410 53 39 idea idea NOUN dti-1410 53 40 why why SCONJ dti-1410 53 41 we we PRON dti-1410 53 42 failed fail VERB dti-1410 53 43 to to PART dti-1410 53 44 confirm confirm VERB dti-1410 53 45 such such DET dti-1410 53 46 an an DET dti-1410 53 47 effect effect NOUN dti-1410 53 48 in in ADP dti-1410 53 49 the the DET dti-1410 53 50 present present ADJ dti-1410 53 51 patient patient NOUN dti-1410 53 52 ; ; PUNCT dti-1410 53 53 however however ADV dti-1410 53 54 , , PUNCT dti-1410 53 55 it it PRON dti-1410 53 56 may may AUX dti-1410 53 57 be be AUX dti-1410 53 58 reasonable reasonable ADJ dti-1410 53 59 to to PART dti-1410 53 60 consider consider VERB dti-1410 53 61 that that SCONJ dti-1410 53 62 her her PRON dti-1410 53 63 volume volume NOUN dti-1410 53 64 overload overload NOUN dti-1410 53 65 status status NOUN dti-1410 53 66 might might AUX dti-1410 53 67 have have AUX dti-1410 53 68 masked mask VERB dti-1410 53 69 the the DET dti-1410 53 70 diuresis diuresis NOUN dti-1410 53 71 - - PUNCT dti-1410 53 72 dependent dependent ADJ dti-1410 53 73 antihypertensive antihypertensive ADJ dti-1410 53 74 properties.14 properties.14 NOUN dti-1410 53 75 otherwise otherwise ADV dti-1410 53 76 , , PUNCT dti-1410 53 77 what what DET dti-1410 53 78 subtypes subtype NOUN dti-1410 53 79 of of ADP dti-1410 53 80 diabetic diabetic ADJ dti-1410 53 81 subjects subject NOUN dti-1410 53 82 are be AUX dti-1410 53 83 vulnerable vulnerable ADJ dti-1410 53 84 to to ADP dti-1410 53 85 these these DET dti-1410 53 86 kinds kind NOUN dti-1410 53 87 of of ADP dti-1410 53 88 agents agent NOUN dti-1410 53 89 also also ADV dti-1410 53 90 needs need VERB dti-1410 53 91 to to PART dti-1410 53 92 be be AUX dti-1410 53 93 assessed assess VERB dti-1410 53 94 in in ADP dti-1410 53 95 more more ADJ dti-1410 53 96 detail detail NOUN dti-1410 53 97 . . PUNCT dti-1410 54 1 a a DET dti-1410 54 2 case case NOUN dti-1410 54 3 of of ADP dti-1410 54 4 volume volume NOUN dti-1410 54 5 depletion depletion NOUN dti-1410 54 6 and and CCONJ dti-1410 54 7 prerenal prerenal ADJ dti-1410 54 8 azotemia azotemia NOUN dti-1410 54 9 that that PRON dti-1410 54 10 required require VERB dti-1410 54 11 rehydration rehydration NOUN dti-1410 54 12 and and CCONJ dti-1410 54 13 the the DET dti-1410 54 14 withdrawal withdrawal NOUN dti-1410 54 15 of of ADP dti-1410 54 16 angiotensin angiotensin NOUN dti-1410 54 17 - - PUNCT dti-1410 54 18 converting convert VERB dti-1410 54 19 inhibitor inhibitor NOUN dti-1410 54 20 and and CCONJ dti-1410 54 21 diuretic diuretic ADJ dti-1410 54 22 treatment treatment NOUN dti-1410 54 23 was be AUX dti-1410 54 24 recently recently ADV dti-1410 54 25 reported report VERB dti-1410 54 26 in in ADP dti-1410 54 27 a a DET dti-1410 54 28 phase phase NOUN dti-1410 54 29 ii ii NOUN dti-1410 54 30 trial trial NOUN dti-1410 54 31 of of ADP dti-1410 54 32 dapagliflozin.15 dapagliflozin.15 NOUN dti-1410 54 33 not not PART dti-1410 54 34 surprisingly surprisingly ADV dti-1410 54 35 , , PUNCT dti-1410 54 36 dapagliflozin dapagliflozin PROPN dti-1410 54 37 was be AUX dti-1410 54 38 effective effective ADJ dti-1410 54 39 and and CCONJ dti-1410 54 40 well well ADV dti-1410 54 41 tolerated tolerate VERB dti-1410 54 42 as as ADP dti-1410 54 43 an an DET dti-1410 54 44 adequate adequate ADJ dti-1410 54 45 therapeutic therapeutic ADJ dti-1410 54 46 option option NOUN dti-1410 54 47 for for ADP dti-1410 54 48 modulating modulate VERB dti-1410 54 49 the the DET dti-1410 54 50 present present ADJ dti-1410 54 51 patient patient NOUN dti-1410 54 52 ’s ’s PART dti-1410 54 53 level level NOUN dti-1410 54 54 of of ADP dti-1410 54 55 glycemic glycemic ADJ dti-1410 54 56 control control NOUN dti-1410 54 57 . . PUNCT dti-1410 55 1 our our PRON dti-1410 55 2 experience experience NOUN dti-1410 55 3 with with ADP dti-1410 55 4 this this DET dti-1410 55 5 agent agent NOUN dti-1410 55 6 in in ADP dti-1410 55 7 the the DET dti-1410 55 8 current current ADJ dti-1410 55 9 patient patient NOUN dti-1410 55 10 rather rather ADV dti-1410 55 11 emphasizes emphasize VERB dti-1410 55 12 a a DET dti-1410 55 13 potential potential ADJ dti-1410 55 14 approach approach NOUN dti-1410 55 15 for for ADP dti-1410 55 16 overcoming overcome VERB dti-1410 55 17 loop loop NOUN dti-1410 55 18 diuretic diuretic ADJ dti-1410 55 19 resistance resistance NOUN dti-1410 55 20 among among ADP dti-1410 55 21 some some DET dti-1410 55 22 subsets subset NOUN dti-1410 55 23 of of ADP dti-1410 55 24 type type NOUN dti-1410 55 25 2 2 NUM dti-1410 55 26 diabetic diabetic ADJ dti-1410 55 27 subjects subject NOUN dti-1410 55 28 complicated complicate VERB dti-1410 55 29 with with ADP dti-1410 55 30 severe severe ADJ dti-1410 55 31 volume volume NOUN dti-1410 55 32 accumulation accumulation NOUN dti-1410 55 33 . . PUNCT dti-1410 56 1 indeed indeed ADV dti-1410 56 2 , , PUNCT dti-1410 56 3 dapagliflozin dapagliflozin PROPN dti-1410 56 4 seemed seem VERB dti-1410 56 5 to to PART dti-1410 56 6 play play VERB dti-1410 56 7 a a DET dti-1410 56 8 role role NOUN dti-1410 56 9 in in ADP dti-1410 56 10 accelerating accelerate VERB dti-1410 56 11 urinary urinary ADJ dti-1410 56 12 sodium sodium NOUN dti-1410 56 13 excretion excretion NOUN dti-1410 56 14 as as ADV dti-1410 56 15 well well ADV dti-1410 56 16 as as ADP dti-1410 56 17 reducing reduce VERB dti-1410 56 18 the the DET dti-1410 56 19 considerable considerable ADJ dti-1410 56 20 fluid fluid ADJ dti-1410 56 21 retention retention NOUN dti-1410 56 22 in in ADP dti-1410 56 23 the the DET dti-1410 56 24 current current ADJ dti-1410 56 25 patient patient NOUN dti-1410 56 26 despite despite SCONJ dti-1410 56 27 the the DET dti-1410 56 28 fact fact NOUN dti-1410 56 29 that that SCONJ dti-1410 56 30 her her PRON dti-1410 56 31 nephrotic nephrotic ADJ dti-1410 56 32 condition condition NOUN dti-1410 56 33 was be AUX dti-1410 56 34 resistant resistant ADJ dti-1410 56 35 to to PART dti-1410 56 36 furosemide furosemide VERB dti-1410 56 37 . . PUNCT dti-1410 57 1 the the DET dti-1410 57 2 fact fact NOUN dti-1410 57 3 that that SCONJ dti-1410 57 4 the the DET dti-1410 57 5 natriuretic natriuretic ADJ dti-1410 57 6 effect effect NOUN dti-1410 57 7 of of ADP dti-1410 57 8 dapagliflozin dapagliflozin PROPN dti-1410 57 9 did do AUX dti-1410 57 10 not not PART dti-1410 57 11 persist persist VERB dti-1410 57 12 may may AUX dti-1410 57 13 be be AUX dti-1410 57 14 ascribed ascribe VERB dti-1410 57 15 to to ADP dti-1410 57 16 the the DET dti-1410 57 17 establishment establishment NOUN dti-1410 57 18 of of ADP dti-1410 57 19 a a DET dti-1410 57 20 new new ADJ dti-1410 57 21 steady steady ADJ dti-1410 57 22 state state NOUN dti-1410 57 23 , , PUNCT dti-1410 57 24 in in ADP dti-1410 57 25 which which PRON dti-1410 57 26 the the DET dti-1410 57 27 patient patient NOUN dti-1410 57 28 ’s ’s PART dti-1410 57 29 depleted depleted ADJ dti-1410 57 30 volume volume NOUN dti-1410 57 31 status status NOUN dti-1410 57 32 and and CCONJ dti-1410 57 33 increased increase VERB dti-1410 57 34 activity activity NOUN dti-1410 57 35 of of ADP dti-1410 57 36 the the DET dti-1410 57 37 renin renin ADJ dti-1410 57 38 angiotensin angiotensin NOUN dti-1410 57 39 system system NOUN dti-1410 57 40 stimulated stimulate VERB dti-1410 57 41 renal renal ADJ dti-1410 57 42 sodium sodium NOUN dti-1410 57 43 uptake uptake ADJ dti-1410 57 44 through through ADP dti-1410 57 45 alternate alternate ADJ dti-1410 57 46 pathways pathway NOUN dti-1410 57 47 and and CCONJ dti-1410 57 48 compensated compensate VERB dti-1410 57 49 for for ADP dti-1410 57 50 the the DET dti-1410 57 51 natriuretic natriuretic ADJ dti-1410 57 52 effect effect NOUN dti-1410 57 53 of of ADP dti-1410 57 54 the the DET dti-1410 57 55 agent.6,16 agent.6,16 PROPN dti-1410 57 56 finally finally ADV dti-1410 57 57 , , PUNCT dti-1410 57 58 we we PRON dti-1410 57 59 believe believe VERB dti-1410 57 60 that that SCONJ dti-1410 57 61 combination combination NOUN dti-1410 57 62 treatment treatment NOUN dti-1410 57 63 consisting consist VERB dti-1410 57 64 of of ADP dti-1410 57 65 dapagliflozin dapagliflozin NOUN dti-1410 57 66 and and CCONJ dti-1410 57 67 furosemide furosemide NOUN dti-1410 57 68 may may AUX dti-1410 57 69 have have AUX dti-1410 57 70 produced produce VERB dti-1410 57 71 diuretic diuretic ADJ dti-1410 57 72 synergy synergy NOUN dti-1410 57 73 via via ADP dti-1410 57 74 the the DET dti-1410 57 75 sequential sequential ADJ dti-1410 57 76 blockade blockade NOUN dti-1410 57 77 of of ADP dti-1410 57 78 solute solute ADJ dti-1410 57 79 reabsorption reabsorption NOUN dti-1410 57 80 at at ADP dti-1410 57 81 the the DET dti-1410 57 82 proximal proximal ADJ dti-1410 57 83 tubules tubule NOUN dti-1410 57 84 and and CCONJ dti-1410 57 85 at at ADP dti-1410 57 86 the the DET dti-1410 57 87 thick thick ADJ dti-1410 57 88 ascending ascend VERB dti-1410 57 89 limb limb NOUN dti-1410 57 90 of of ADP dti-1410 57 91 the the DET dti-1410 57 92 loop loop NOUN dti-1410 57 93 of of ADP dti-1410 57 94 henle henle PROPN dti-1410 57 95 in in ADP dti-1410 57 96     SPACE dti-1410 57 97 our our PRON dti-1410 57 98 patient patient NOUN dti-1410 57 99 . . PUNCT dti-1410 58 1 the the DET dti-1410 58 2 lack lack NOUN dti-1410 58 3 of of ADP dti-1410 58 4 longitudinal longitudinal ADJ dti-1410 58 5 data datum NOUN dti-1410 58 6 regarding regard VERB dti-1410 58 7 the the DET dti-1410 58 8 gross gross ADJ dti-1410 58 9 daily daily ADJ dti-1410 58 10 urine urine NOUN dti-1410 58 11 output output NOUN dti-1410 58 12 , , PUNCT dti-1410 58 13 as as ADV dti-1410 58 14 well well ADV dti-1410 58 15 as as ADP dti-1410 58 16 the the DET dti-1410 58 17 amount amount NOUN dti-1410 58 18 of of ADP dti-1410 58 19 urinary urinary ADJ dti-1410 58 20 excreted excrete VERB dti-1410 58 21 sodium sodium NOUN dti-1410 58 22 after after ADP dti-1410 58 23 the the DET dti-1410 58 24 commencement commencement NOUN dti-1410 58 25 of of ADP dti-1410 58 26 oral oral ADJ dti-1410 58 27 dapagliflozin dapagliflozin NOUN dti-1410 58 28 treatment treatment NOUN dti-1410 58 29 in in ADP dti-1410 58 30 the the DET dti-1410 58 31 previous previous ADJ dti-1410 58 32 studies study NOUN dti-1410 58 33 , , PUNCT dti-1410 58 34 precludes preclude VERB dti-1410 58 35 us we PRON dti-1410 58 36 from from ADP dti-1410 58 37 evaluating evaluate VERB dti-1410 58 38 the the DET dti-1410 58 39 validity validity NOUN dti-1410 58 40 of of ADP dti-1410 58 41 our our PRON dti-1410 58 42 findings.10–12 findings.10–12 NOUN dti-1410 58 43 nevertheless nevertheless ADV dti-1410 58 44 , , PUNCT dti-1410 58 45 list list NOUN dti-1410 58 46 et et PROPN dti-1410 58 47 al al PROPN dti-1410 58 48 , , PUNCT dti-1410 58 49 demonstrated demonstrate VERB dti-1410 58 50 that that SCONJ dti-1410 58 51 the the DET dti-1410 58 52 administration administration NOUN dti-1410 58 53 of of ADP dti-1410 58 54 dapagliflozin dapagliflozin PROPN dti-1410 58 55 in in ADP dti-1410 58 56 treatment treatment NOUN dti-1410 58 57 - - PUNCT dti-1410 58 58 naive naive ADJ dti-1410 58 59 patients patient NOUN dti-1410 58 60 with with ADP dti-1410 58 61 type type NOUN dti-1410 58 62 2 2 NUM dti-1410 58 63 diabetes diabetes NOUN dti-1410 58 64 resulted result VERB dti-1410 58 65 in in ADP dti-1410 58 66 an an DET dti-1410 58 67 increased increase VERB dti-1410 58 68 urinary urinary ADJ dti-1410 58 69 output output NOUN dti-1410 58 70 of of ADP dti-1410 58 71 between between ADP dti-1410 58 72 107 107 NUM dti-1410 58 73     SPACE dti-1410 58 74 ml ml NOUN dti-1410 58 75 / / SYM dti-1410 58 76 day day NOUN dti-1410 58 77 and and CCONJ dti-1410 58 78 470 470 NUM dti-1410 58 79     SPACE dti-1410 58 80 ml ml NOUN dti-1410 58 81 / / SYM dti-1410 58 82 day day NOUN dti-1410 58 83 , , PUNCT dti-1410 58 84 equating equate VERB dti-1410 58 85 to to ADP dti-1410 58 86 ~0.3–1.5 ~0.3–1.5 PRON dti-1410 58 87 additional additional ADJ dti-1410 58 88 voids voids NOUN dti-1410 58 89 per per ADP dti-1410 58 90 day.1,17 day.1,17 NOUN dti-1410 58 91 this this DET dti-1410 58 92 highlights highlight NOUN dti-1410 58 93 the the DET dti-1410 58 94 need need NOUN dti-1410 58 95 for for ADP dti-1410 58 96 further further ADJ dti-1410 58 97 investigation investigation NOUN dti-1410 58 98 regarding regard VERB dti-1410 58 99 the the DET dti-1410 58 100 impact impact NOUN dti-1410 58 101 of of ADP dti-1410 58 102 the the DET dti-1410 58 103 diuretic diuretic ADJ dti-1410 58 104 properties property NOUN dti-1410 58 105 of of ADP dti-1410 58 106 this this DET dti-1410 58 107 agent agent NOUN dti-1410 58 108 on on ADP dti-1410 58 109 the the DET dti-1410 58 110 overall overall ADJ dti-1410 58 111 management management NOUN dti-1410 58 112 of of ADP dti-1410 58 113 diabetic diabetic ADJ dti-1410 58 114 patients.9 patients.9 NOUN dti-1410 58 115 obviously obviously ADV dti-1410 58 116 , , PUNCT dti-1410 58 117 the the DET dti-1410 58 118 accumulation accumulation NOUN dti-1410 58 119 of of ADP dti-1410 58 120 more more ADJ dti-1410 58 121 experience experience NOUN dti-1410 58 122 with with ADP dti-1410 58 123 additional additional ADJ dti-1410 58 124 cases case NOUN dti-1410 58 125 similar similar ADJ dti-1410 58 126 to to ADP dti-1410 58 127 ours ours PRON dti-1410 58 128 requires require VERB dti-1410 58 129 continuous continuous ADJ dti-1410 58 130 and and CCONJ dti-1410 58 131 careful careful ADJ dti-1410 58 132 attention attention NOUN dti-1410 58 133 , , PUNCT dti-1410 58 134 and and CCONJ dti-1410 58 135 such such DET dti-1410 58 136 a a DET dti-1410 58 137 strategy strategy NOUN dti-1410 58 138 would would AUX dti-1410 58 139 aid aid VERB dti-1410 58 140 in in ADP dti-1410 58 141 the the DET dti-1410 58 142 establishment establishment NOUN dti-1410 58 143 of of ADP dti-1410 58 144 a a DET dti-1410 58 145 novel novel ADJ dti-1410 58 146 approach approach NOUN dti-1410 58 147 to to ADP dti-1410 58 148 treating treat VERB dti-1410 58 149 fluid fluid ADJ dti-1410 58 150 retention retention NOUN dti-1410 58 151 as as ADV dti-1410 58 152 well well ADV dti-1410 58 153 as as ADP dti-1410 58 154 investigating investigate VERB dti-1410 58 155 the the DET dti-1410 58 156 therapeutic therapeutic ADJ dti-1410 58 157 impact impact NOUN dti-1410 58 158 of of ADP dti-1410 58 159 sglt-2 sglt-2 NUM dti-1410 58 160 inhibitors inhibitor NOUN dti-1410 58 161 in in ADP dti-1410 58 162 diabetic diabetic ADJ dti-1410 58 163 patients patient NOUN dti-1410 58 164 with with ADP dti-1410 58 165 nephrotic nephrotic ADJ dti-1410 58 166 syndrome syndrome NOUN dti-1410 58 167 . . PUNCT dti-1410 59 1 author author NOUN dti-1410 59 2 contributions contribution NOUN dti-1410 59 3 drafted draft VERB dti-1410 59 4 the the DET dti-1410 59 5 manuscript manuscript NOUN dti-1410 59 6 : : PUNCT dti-1410 59 7 ti ti PROPN dti-1410 59 8 and and CCONJ dti-1410 59 9 ta ta PROPN dti-1410 59 10 . . PROPN dti-1410 59 11 made make VERB dti-1410 59 12 contributions contribution NOUN dti-1410 59 13 to to ADP dti-1410 59 14 the the DET dti-1410 59 15 acquisition acquisition NOUN dti-1410 59 16 of of ADP dti-1410 59 17 the the DET dti-1410 59 18 clinical clinical ADJ dti-1410 59 19 data datum NOUN dti-1410 59 20 : : PUNCT dti-1410 59 21 ci ci PROPN dti-1410 59 22 and and CCONJ dti-1410 59 23 tm tm PROPN dti-1410 59 24 . . PROPN dti-1410 59 25 provided provide VERB dti-1410 59 26 a a DET dti-1410 59 27 detailed detailed ADJ dti-1410 59 28 review review NOUN dti-1410 59 29 of of ADP dti-1410 59 30 the the DET dti-1410 59 31 contents content NOUN dti-1410 59 32 and and CCONJ dti-1410 59 33 structure structure NOUN dti-1410 59 34 of of ADP dti-1410 59 35 the the DET dti-1410 59 36 manuscript manuscript NOUN dti-1410 59 37 , , PUNCT dti-1410 59 38 resulting result VERB dti-1410 59 39 in in ADP dti-1410 59 40 significant significant ADJ dti-1410 59 41 changes change NOUN dti-1410 59 42 to to ADP dti-1410 59 43 the the DET dti-1410 59 44 original original ADJ dti-1410 59 45 document document NOUN dti-1410 59 46 : : PUNCT dti-1410 60 1 dn dn X dti-1410 60 2 . . PUNCT dti-1410 61 1 all all DET dti-1410 61 2 authors author NOUN dti-1410 61 3 have have AUX dti-1410 61 4 read read VERB dti-1410 61 5 and and CCONJ dti-1410 61 6 approved approve VERB dti-1410 61 7 the the DET dti-1410 61 8 final final ADJ dti-1410 61 9 manuscript manuscript NOUN dti-1410 61 10 . . PUNCT dti-1410 62 1 references reference NOUN dti-1410 62 2 1 1 NUM dti-1410 62 3 . . X dti-1410 62 4 list list PROPN dti-1410 62 5 jf jf PROPN dti-1410 62 6 , , PUNCT dti-1410 62 7 woo woo VERB dti-1410 62 8 v v ADP dti-1410 62 9 , , PUNCT dti-1410 62 10 morales morales PROPN dti-1410 62 11 e e PROPN dti-1410 62 12 , , PUNCT dti-1410 62 13 tang tang PROPN dti-1410 62 14 w w PROPN dti-1410 62 15 , , PUNCT dti-1410 62 16 fiedorek fiedorek NOUN dti-1410 62 17 ft ft PROPN dti-1410 62 18 . . PROPN dti-1410 62 19 sodium sodium NOUN dti-1410 62 20 - - PUNCT dti-1410 62 21 glucose glucose NOUN dti-1410 62 22 cotransport cotransport NOUN dti-1410 62 23 inhibition inhibition NOUN dti-1410 62 24 with with ADP dti-1410 62 25 dapagliflozin dapagliflozin NOUN dti-1410 62 26 in in ADP dti-1410 62 27 type type NOUN dti-1410 62 28 2 2 NUM dti-1410 62 29 diabetes diabetes NOUN dti-1410 62 30 . . PUNCT dti-1410 63 1 diabetes diabetes NOUN dti-1410 63 2 care care VERB dti-1410 63 3 . . PUNCT dti-1410 64 1 2009;32(4 2009;32(4 NUM dti-1410 64 2 ): ): PUNCT dti-1410 64 3 650–657 650–657 NUM dti-1410 64 4 . . PUNCT dti-1410 65 1 2 2 NUM dti-1410 65 2 . . X dti-1410 65 3 onoyama onoyama NOUN dti-1410 66 1 k k PROPN dti-1410 66 2 , , PUNCT dti-1410 66 3 kumagai kumagai NOUN dti-1410 66 4 h h NOUN dti-1410 66 5 , , PUNCT dti-1410 66 6 fujishima fujishima PROPN dti-1410 66 7 m. m. PROPN dti-1410 66 8 hemodynamic hemodynamic ADJ dti-1410 66 9 and and CCONJ dti-1410 66 10 volume volume NOUN dti-1410 66 11 changes change NOUN dti-1410 66 12 by by ADP dti-1410 66 13 ultrafiltration ultrafiltration NOUN dti-1410 66 14 in in ADP dti-1410 66 15 refractory refractory NOUN dti-1410 66 16 edema edema NOUN dti-1410 66 17 of of ADP dti-1410 66 18 diabetic diabetic ADJ dti-1410 66 19 nephrotic nephrotic ADJ dti-1410 66 20 syndrome syndrome NOUN dti-1410 66 21 with with ADP dti-1410 66 22 severe severe ADJ dti-1410 66 23 renal renal ADJ dti-1410 66 24 insufficiency insufficiency NOUN dti-1410 66 25 . . PUNCT dti-1410 67 1 clin clin PROPN dti-1410 67 2 nephrol nephrol PROPN dti-1410 67 3 . . PUNCT dti-1410 68 1 1987;27(1):21–25 1987;27(1):21–25 NUM dti-1410 68 2 . . NOUN dti-1410 68 3 3 3 NUM dti-1410 68 4 . . PUNCT dti-1410 68 5 davenport davenport PROPN dti-1410 68 6 a. a. NOUN dti-1410 68 7 ultrafiltration ultrafiltration NOUN dti-1410 68 8 in in ADP dti-1410 68 9 diuretic diuretic ADJ dti-1410 68 10 - - PUNCT dti-1410 68 11 resistant resistant ADJ dti-1410 68 12 volume volume NOUN dti-1410 68 13 overload overload NOUN dti-1410 68 14 in in ADP dti-1410 68 15 nephrotic nephrotic ADJ dti-1410 68 16 syndrome syndrome NOUN dti-1410 68 17 and and CCONJ dti-1410 68 18 patients patient NOUN dti-1410 68 19 with with ADP dti-1410 68 20 ascites ascite NOUN dti-1410 68 21 due due ADJ dti-1410 68 22 to to ADP dti-1410 68 23 chronic chronic ADJ dti-1410 68 24 liver liver NOUN dti-1410 68 25 disease disease NOUN dti-1410 68 26 . . PUNCT dti-1410 69 1 cardiology cardiology NOUN dti-1410 69 2 . . PUNCT dti-1410 70 1 2001 2001 NUM dti-1410 70 2 ; ; PUNCT dti-1410 71 1 96(3–4):190–195 96(3–4):190–195 NUM dti-1410 71 2 . . NOUN dti-1410 71 3 4 4 X dti-1410 71 4 . . X dti-1410 71 5 brater brater PROPN dti-1410 71 6 dc dc PROPN dti-1410 71 7 . . PUNCT dti-1410 71 8 diuretic diuretic ADJ dti-1410 71 9 resistance resistance NOUN dti-1410 71 10 : : PUNCT dti-1410 71 11 mechanisms mechanism NOUN dti-1410 71 12 and and CCONJ dti-1410 71 13 therapeutic therapeutic ADJ dti-1410 71 14 strategies strategy NOUN dti-1410 71 15 . . PUNCT dti-1410 72 1 cardiology cardiology NOUN dti-1410 72 2 . . PUNCT dti-1410 73 1 1994;84(suppl 1994;84(suppl PROPN dti-1410 73 2 2):57–67 2):57–67 NUM dti-1410 73 3 . . NOUN dti-1410 73 4 5 5 NUM dti-1410 73 5 . . NOUN dti-1410 73 6 vallon vallon PROPN dti-1410 73 7 v v NOUN dti-1410 73 8 , , PUNCT dti-1410 73 9 platt platt PROPN dti-1410 73 10 ka ka PROPN dti-1410 73 11 , , PUNCT dti-1410 73 12 cunard cunard PROPN dti-1410 73 13 r r NOUN dti-1410 73 14 , , PUNCT dti-1410 73 15 et et PROPN dti-1410 73 16 al al PROPN dti-1410 73 17 . . PROPN dti-1410 73 18 sglt2 sglt2 PROPN dti-1410 73 19 mediates mediate VERB dti-1410 73 20 glucose glucose NOUN dti-1410 73 21 reabsorption reabsorption NOUN dti-1410 73 22 in in ADP dti-1410 73 23 the the DET dti-1410 73 24 early early ADJ dti-1410 73 25 proximal proximal ADJ dti-1410 73 26 tubule tubule NOUN dti-1410 73 27 . . PUNCT dti-1410 74 1 j j PROPN dti-1410 74 2 am be AUX dti-1410 74 3 soc soc NOUN dti-1410 74 4 nephrol nephrol NOUN dti-1410 74 5 . . PUNCT dti-1410 75 1 2011;22(1):104–112 2011;22(1):104–112 X dti-1410 75 2 . . NOUN dti-1410 76 1 6 6 NUM dti-1410 76 2 . . X dti-1410 76 3 gallo gallo PROPN dti-1410 76 4 la la PROPN dti-1410 76 5 , , PUNCT dti-1410 76 6 wright wright PROPN dti-1410 76 7 em em PRON dti-1410 76 8 , , PUNCT dti-1410 76 9 vallon vallon NOUN dti-1410 76 10 v. v. ADP dti-1410 76 11 probing probe VERB dti-1410 76 12 sglt2 sglt2 PROPN dti-1410 76 13 as as ADP dti-1410 76 14 a a DET dti-1410 76 15 therapeutic therapeutic ADJ dti-1410 76 16 target target NOUN dti-1410 76 17 for for ADP dti-1410 76 18 diabetes diabetes NOUN dti-1410 76 19 : : PUNCT dti-1410 76 20 basic basic ADJ dti-1410 76 21 physiology physiology NOUN dti-1410 76 22 and and CCONJ dti-1410 76 23 consequences consequence NOUN dti-1410 76 24 . . PUNCT dti-1410 77 1 diab diab PROPN dti-1410 77 2 vasc vasc PROPN dti-1410 77 3 dis dis PROPN dti-1410 77 4 res re NOUN dti-1410 77 5 . . PUNCT dti-1410 78 1 2015;12(2):78–89 2015;12(2):78–89 X dti-1410 78 2 . . NOUN dti-1410 78 3 7 7 NUM dti-1410 78 4 . . X dti-1410 78 5 musso musso PROPN dti-1410 78 6 g g PROPN dti-1410 78 7 , , PUNCT dti-1410 78 8 gambino gambino PROPN dti-1410 78 9 r r PROPN dti-1410 78 10 , , PUNCT dti-1410 78 11 cassader cassader NOUN dti-1410 78 12 m m PROPN dti-1410 78 13 , , PUNCT dti-1410 78 14 pagano pagano PROPN dti-1410 78 15 g. g. PROPN dti-1410 78 16 a a DET dti-1410 78 17 novel novel ADJ dti-1410 78 18 approach approach NOUN dti-1410 78 19 to to PART dti-1410 78 20 control control VERB dti-1410 78 21 hyperglycemia hyperglycemia NOUN dti-1410 78 22 in in ADP dti-1410 78 23 type type NOUN dti-1410 78 24 2 2 NUM dti-1410 78 25 diabetes diabetes NOUN dti-1410 78 26 : : PUNCT dti-1410 78 27 sodium sodium NOUN dti-1410 78 28 glucose glucose NOUN dti-1410 78 29 co co NOUN dti-1410 78 30 - - NOUN dti-1410 78 31 transport transport ADJ dti-1410 78 32 ( ( PUNCT dti-1410 78 33 sglt sglt ADJ dti-1410 78 34 ) ) PUNCT dti-1410 78 35 inhibitors inhibitor NOUN dti-1410 78 36 : : PUNCT dti-1410 78 37 systematic systematic ADJ dti-1410 78 38 review review NOUN dti-1410 78 39 and and CCONJ dti-1410 78 40 meta meta NOUN dti-1410 78 41 - - PUNCT dti-1410 78 42 analysis analysis NOUN dti-1410 78 43 of of ADP dti-1410 78 44 randomized randomized ADJ dti-1410 78 45 trials trial NOUN dti-1410 78 46 . . PUNCT dti-1410 79 1 ann ann PROPN dti-1410 79 2 med med PROPN dti-1410 79 3 . . PUNCT dti-1410 80 1 2012;44(4 2012;44(4 NUM dti-1410 80 2 ): ): PUNCT dti-1410 80 3 375–393 375–393 NUM dti-1410 80 4 . . NOUN dti-1410 81 1 8 8 NUM dti-1410 81 2 . . X dti-1410 81 3 shah shah PROPN dti-1410 81 4 nk nk PROPN dti-1410 81 5 , , PUNCT dti-1410 81 6 deeb deeb PROPN dti-1410 81 7 we we PRON dti-1410 81 8 , , PUNCT dti-1410 81 9 choksi choksi PROPN dti-1410 81 10 r r PROPN dti-1410 81 11 , , PUNCT dti-1410 81 12 epstein epstein PROPN dti-1410 81 13 bj bj PROPN dti-1410 81 14 . . PUNCT dti-1410 82 1 dapagliflozin dapagliflozin PROPN dti-1410 82 2 : : PUNCT dti-1410 82 3 a a DET dti-1410 82 4 novel novel ADJ dti-1410 82 5 sodiumglucose sodiumglucose NOUN dti-1410 82 6 cotransporter cotransporter NOUN dti-1410 82 7 type type NOUN dti-1410 82 8 2 2 NUM dti-1410 82 9 inhibitor inhibitor NOUN dti-1410 82 10 for for ADP dti-1410 82 11 the the DET dti-1410 82 12 treatment treatment NOUN dti-1410 82 13 of of ADP dti-1410 82 14 type type NOUN dti-1410 82 15 2 2 NUM dti-1410 82 16 diabetes diabetes NOUN dti-1410 82 17 mellitus mellitus NOUN dti-1410 82 18 . . PUNCT dti-1410 83 1 pharmacotherapy pharmacotherapy NOUN dti-1410 83 2 . . PUNCT dti-1410 84 1 2012;32(1):80–94 2012;32(1):80–94 X dti-1410 84 2 . . NOUN dti-1410 84 3 9 9 NUM dti-1410 84 4 . . X dti-1410 84 5 lambers lamber NOUN dti-1410 84 6 heerspink heerspink VERB dti-1410 84 7 hj hj PROPN dti-1410 84 8 , , PUNCT dti-1410 84 9 de de X dti-1410 84 10 zeeuw zeeuw PROPN dti-1410 84 11 d d PROPN dti-1410 84 12 , , PUNCT dti-1410 84 13 wie wie PROPN dti-1410 84 14 l l PROPN dti-1410 84 15 , , PUNCT dti-1410 84 16 leslie leslie PROPN dti-1410 84 17 b b PROPN dti-1410 84 18 , , PUNCT dti-1410 84 19 list list NOUN dti-1410 84 20 j. j. PROPN dti-1410 84 21 dapagliflozin dapagliflozin PROPN dti-1410 84 22 a a DET dti-1410 84 23 glucose glucose NOUN dti-1410 84 24 - - PUNCT dti-1410 84 25 regulating regulate VERB dti-1410 84 26 drug drug NOUN dti-1410 84 27 with with ADP dti-1410 84 28 diuretic diuretic ADJ dti-1410 84 29 properties property NOUN dti-1410 84 30 in in ADP dti-1410 84 31 subjects subject NOUN dti-1410 84 32 with with ADP dti-1410 84 33 type type NOUN dti-1410 84 34 2 2 NUM dti-1410 84 35 diabetes diabetes NOUN dti-1410 84 36 . . PUNCT dti-1410 85 1 diabetes diabetes NOUN dti-1410 85 2 obes obes PRON dti-1410 85 3 metab metab ADJ dti-1410 85 4 . . PUNCT dti-1410 86 1 2013;15(9):853–862 2013;15(9):853–862 NUM dti-1410 86 2 . . X dti-1410 86 3 10 10 NUM dti-1410 86 4 . . PUNCT dti-1410 86 5 komoroski komoroski PROPN dti-1410 86 6 b b PROPN dti-1410 86 7 , , PUNCT dti-1410 86 8 vachharajani vachharajani NOUN dti-1410 86 9 n n CCONJ dti-1410 86 10 , , PUNCT dti-1410 86 11 feng feng PROPN dti-1410 86 12 y y PROPN dti-1410 86 13 , , PUNCT dti-1410 86 14 li li PROPN dti-1410 86 15 l l PROPN dti-1410 86 16 , , PUNCT dti-1410 86 17 kornhauser kornhauser PROPN dti-1410 86 18 d d PROPN dti-1410 86 19 , , PUNCT dti-1410 86 20 pfister pfister NOUN dti-1410 86 21 m. m. NOUN dti-1410 86 22 dapagliflozin dapagliflozin PROPN dti-1410 86 23 , , PUNCT dti-1410 86 24 a a DET dti-1410 86 25 novel novel NOUN dti-1410 86 26 , , PUNCT dti-1410 86 27 selective selective ADJ dti-1410 86 28 sglt2 sglt2 NOUN dti-1410 86 29 inhibitor inhibitor NOUN dti-1410 86 30 , , PUNCT dti-1410 86 31 improved improve VERB dti-1410 86 32 glycemic glycemic ADJ dti-1410 86 33 control control NOUN dti-1410 86 34 over over ADP dti-1410 86 35 2 2 NUM dti-1410 86 36     SPACE dti-1410 86 37 weeks week NOUN dti-1410 86 38 in in ADP dti-1410 86 39 patients patient NOUN dti-1410 86 40 with with ADP dti-1410 86 41 type type NOUN dti-1410 86 42 2 2 NUM dti-1410 86 43 diabetes diabetes NOUN dti-1410 86 44 mellitus mellitus NOUN dti-1410 86 45 . . PUNCT dti-1410 87 1 clin clin PROPN dti-1410 87 2 pharmacol pharmacol PROPN dti-1410 87 3 ther ther ADV dti-1410 87 4 . . PUNCT dti-1410 88 1 2009;85(5 2009;85(5 NUM dti-1410 88 2 ): ): PUNCT dti-1410 89 1 513–519 513–519 NUM dti-1410 89 2 . . PUNCT dti-1410 90 1 11 11 NUM dti-1410 90 2 . . PUNCT dti-1410 90 3 devineni devineni PROPN dti-1410 90 4 d d PROPN dti-1410 90 5 , , PUNCT dti-1410 90 6 morrow morrow PROPN dti-1410 90 7 l l PROPN dti-1410 90 8 , , PUNCT dti-1410 90 9 hompesch hompesch PROPN dti-1410 90 10 m m PROPN dti-1410 90 11 , , PUNCT dti-1410 90 12 et et PROPN dti-1410 90 13 al al PROPN dti-1410 90 14 . . PROPN dti-1410 90 15 canagliflozin canagliflozin PROPN dti-1410 90 16 improves improve VERB dti-1410 90 17 glycaemic glycaemic ADJ dti-1410 90 18 control control NOUN dti-1410 90 19 over over ADP dti-1410 90 20 28 28 NUM dti-1410 90 21 days day NOUN dti-1410 90 22 in in ADP dti-1410 90 23 subjects subject NOUN dti-1410 90 24 with with ADP dti-1410 90 25 type type NOUN dti-1410 90 26 2 2 NUM dti-1410 90 27 diabetes diabete NOUN dti-1410 90 28 not not PART dti-1410 90 29 optimally optimally ADV dti-1410 90 30 controlled control VERB dti-1410 90 31 on on ADP dti-1410 90 32 insulin insulin NOUN dti-1410 90 33 . . PUNCT dti-1410 91 1 diabetes diabetes NOUN dti-1410 91 2 obes obe VERB dti-1410 91 3 metab metab ADJ dti-1410 91 4 . . PUNCT dti-1410 92 1 2012;14(6):539–545 2012;14(6):539–545 NUM dti-1410 92 2 . . NOUN dti-1410 92 3 12 12 NUM dti-1410 92 4 . . PUNCT dti-1410 93 1 devineni devineni PROPN dti-1410 93 2 d d PROPN dti-1410 93 3 , , PUNCT dti-1410 93 4 vaccaro vaccaro PROPN dti-1410 93 5 n n CCONJ dti-1410 93 6 , , PUNCT dti-1410 93 7 polidori polidori PROPN dti-1410 93 8 d d PROPN dti-1410 93 9 , , PUNCT dti-1410 93 10 rusch rusch PROPN dti-1410 93 11 s s PROPN dti-1410 93 12 , , PUNCT dti-1410 93 13 wajs wajs PROPN dti-1410 93 14 e. e. PROPN dti-1410 93 15 effects effect NOUN dti-1410 93 16 of of ADP dti-1410 93 17 hydrochlorothiazide hydrochlorothiazide NOUN dti-1410 93 18 on on ADP dti-1410 93 19 the the DET dti-1410 93 20 pharmacokinetics pharmacokinetic NOUN dti-1410 93 21 , , PUNCT dti-1410 93 22 pharmacodynamics pharmacodynamic NOUN dti-1410 93 23 , , PUNCT dti-1410 93 24 and and CCONJ dti-1410 93 25 tolerability tolerability NOUN dti-1410 93 26 of of ADP dti-1410 93 27 canagliflozin canagliflozin NOUN dti-1410 93 28 , , PUNCT dti-1410 93 29 a a DET dti-1410 93 30 sodium sodium NOUN dti-1410 93 31 glucose glucose NOUN dti-1410 93 32 co co NOUN dti-1410 93 33 - - NOUN dti-1410 93 34 transporter transporter ADJ dti-1410 93 35 2 2 NUM dti-1410 93 36 inhibitor inhibitor NOUN dti-1410 93 37 , , PUNCT dti-1410 93 38 in in ADP dti-1410 93 39 healthy healthy ADJ dti-1410 93 40 participants participant NOUN dti-1410 93 41 . . PUNCT dti-1410 94 1 clin clin PROPN dti-1410 94 2 ther ther ADV dti-1410 94 3 . . PUNCT dti-1410 95 1 2014;36(5):698–710 2014;36(5):698–710 NUM dti-1410 95 2 . . PUNCT dti-1410 95 3 13 13 NUM dti-1410 95 4 . . PUNCT dti-1410 96 1 baker baker PROPN dti-1410 96 2 wl wl PROPN dti-1410 96 3 , , PUNCT dti-1410 96 4 smyth smyth PROPN dti-1410 96 5 lr lr PROPN dti-1410 96 6 , , PUNCT dti-1410 96 7 riche riche X dti-1410 96 8 dm dm PROPN dti-1410 96 9 , , PUNCT dti-1410 96 10 bourret bourret VERB dti-1410 96 11 em em PRON dti-1410 96 12 , , PUNCT dti-1410 96 13 chamberlin chamberlin PROPN dti-1410 96 14 kw kw PROPN dti-1410 96 15 , , PUNCT dti-1410 96 16 white white PROPN dti-1410 96 17 wb wb PROPN dti-1410 96 18 . . PROPN dti-1410 96 19 effects effect NOUN dti-1410 96 20 of of ADP dti-1410 96 21 sodium sodium NOUN dti-1410 96 22 - - PUNCT dti-1410 96 23 glucose glucose NOUN dti-1410 96 24 co co NOUN dti-1410 96 25 - - NOUN dti-1410 96 26 transporter transporter ADJ dti-1410 96 27 2 2 NUM dti-1410 96 28 inhibitors inhibitor NOUN dti-1410 96 29 on on ADP dti-1410 96 30 blood blood NOUN dti-1410 96 31 pressure pressure NOUN dti-1410 96 32 : : PUNCT dti-1410 96 33 a a DET dti-1410 96 34 systematic systematic ADJ dti-1410 96 35 review review NOUN dti-1410 96 36 and and CCONJ dti-1410 96 37 meta meta ADJ dti-1410 96 38 - - PUNCT dti-1410 96 39 analysis analysis NOUN dti-1410 96 40 . . PUNCT dti-1410 97 1 j j PROPN dti-1410 97 2 am be AUX dti-1410 97 3 soc soc NOUN dti-1410 97 4 hypertens hyperten NOUN dti-1410 97 5 . . PUNCT dti-1410 98 1 2014;8(4):262–275 2014;8(4):262–275 X dti-1410 98 2 . . NOUN dti-1410 98 3 14 14 NUM dti-1410 98 4 . . PUNCT dti-1410 99 1 meltzer meltzer PROPN dti-1410 99 2 ji ji PROPN dti-1410 99 3 , , PUNCT dti-1410 99 4 keim keim PROPN dti-1410 99 5 hj hj PROPN dti-1410 99 6 , , PUNCT dti-1410 99 7 laragh laragh PROPN dti-1410 99 8 jh jh PROPN dti-1410 99 9 , , PUNCT dti-1410 99 10 sealey sealey PROPN dti-1410 99 11 je je PROPN dti-1410 99 12 , , PUNCT dti-1410 99 13 jan jan PROPN dti-1410 99 14 km km PROPN dti-1410 99 15 , , PUNCT dti-1410 99 16 chien chien PROPN dti-1410 99 17 s. s. PROPN dti-1410 99 18 nephrotic nephrotic PROPN dti-1410 99 19 syndrome syndrome PROPN dti-1410 99 20 : : PUNCT dti-1410 99 21 vasoconstriction vasoconstriction NOUN dti-1410 99 22 and and CCONJ dti-1410 99 23 hypervolemic hypervolemic ADJ dti-1410 99 24 types type NOUN dti-1410 99 25 indicated indicate VERB dti-1410 99 26 by by ADP dti-1410 99 27 renin renin ADJ dti-1410 99 28 - - PUNCT dti-1410 99 29 sodium sodium NOUN dti-1410 99 30 profiling profiling NOUN dti-1410 99 31 . . PUNCT dti-1410 100 1 ann ann PROPN dti-1410 100 2 intern intern PROPN dti-1410 100 3 med me VERB dti-1410 100 4 . . PUNCT dti-1410 101 1 1979;91(5):688–696 1979;91(5):688–696 X dti-1410 101 2 . . PUNCT dti-1410 101 3 15 15 NUM dti-1410 101 4 . . X dti-1410 101 5 wilding wilde VERB dti-1410 101 6 jp jp NOUN dti-1410 101 7 , , PUNCT dti-1410 101 8 norwood norwood PROPN dti-1410 101 9 p p PROPN dti-1410 101 10 , , PUNCT dti-1410 101 11 t t PROPN dti-1410 101 12 ’ ' PUNCT dti-1410 101 13 joen joen VERB dti-1410 101 14 c c NOUN dti-1410 101 15 , , PUNCT dti-1410 101 16 bastien bastien PROPN dti-1410 101 17 a a PRON dti-1410 101 18 , , PUNCT dti-1410 101 19 list list NOUN dti-1410 101 20 jf jf PROPN dti-1410 101 21 , , PUNCT dti-1410 101 22 fiedorek fiedorek NOUN dti-1410 101 23 ft ft PROPN dti-1410 101 24 . . PUNCT dti-1410 102 1 a a DET dti-1410 102 2 study study NOUN dti-1410 102 3 of of ADP dti-1410 102 4 dapagliflozin dapagliflozin PROPN dti-1410 102 5 in in ADP dti-1410 102 6 patients patient NOUN dti-1410 102 7 with with ADP dti-1410 102 8 type type NOUN dti-1410 102 9 2 2 NUM dti-1410 102 10 diabetes diabetes NOUN dti-1410 102 11 receiving receive VERB dti-1410 102 12 high high ADJ dti-1410 102 13 doses dose NOUN dti-1410 102 14 of of ADP dti-1410 102 15 insulin insulin NOUN dti-1410 102 16 plus plus CCONJ dti-1410 102 17 insulin insulin NOUN dti-1410 102 18 sensitizers sensitizer NOUN dti-1410 102 19 : : PUNCT dti-1410 102 20 applicability applicability NOUN dti-1410 102 21 of of ADP dti-1410 102 22 a a DET dti-1410 102 23 novel novel ADJ dti-1410 102 24 insulin insulin NOUN dti-1410 102 25 - - PUNCT dti-1410 102 26 independent independent ADJ dti-1410 102 27 treatment treatment NOUN dti-1410 102 28 . . PUNCT dti-1410 103 1 diabetes diabetes NOUN dti-1410 103 2 care care NOUN dti-1410 103 3 . . PUNCT dti-1410 104 1 2009;32(9):1656–1662 2009;32(9):1656–1662 NOUN dti-1410 104 2 . . PUNCT dti-1410 105 1 16 16 NUM dti-1410 105 2 . . PUNCT dti-1410 106 1 thomas thomas PROPN dti-1410 106 2 mc mc PROPN dti-1410 106 3 , , PUNCT dti-1410 106 4 jandeleit jandeleit PROPN dti-1410 106 5 - - PUNCT dti-1410 106 6 dahm dahm PROPN dti-1410 106 7 k k NOUN dti-1410 106 8 , , PUNCT dti-1410 106 9 bonnet bonnet NOUN dti-1410 106 10 f. f. PROPN dti-1410 106 11 beyond beyond ADP dti-1410 106 12 glycosuria glycosuria NOUN dti-1410 106 13 : : PUNCT dti-1410 106 14 exploring explore VERB dti-1410 106 15 the the DET dti-1410 106 16 intrarenal intrarenal ADJ dti-1410 106 17 effects effect NOUN dti-1410 106 18 of of ADP dti-1410 106 19 sglt-2 sglt-2 NUM dti-1410 106 20 inhibition inhibition NOUN dti-1410 106 21 in in ADP dti-1410 106 22 diabetes diabetes NOUN dti-1410 106 23 . . PUNCT dti-1410 107 1 diabetes diabetes NOUN dti-1410 107 2 metab metab NOUN dti-1410 107 3 . . PUNCT dti-1410 108 1 2014;40 2014;40 NUM dti-1410 108 2 ( ( PUNCT dti-1410 108 3 6 6 NUM dti-1410 108 4 suppl suppl ADJ dti-1410 108 5 1):s17 1):s17 NUM dti-1410 108 6 – – PUNCT dti-1410 108 7 s22 s22 NOUN dti-1410 108 8 . . PUNCT dti-1410 109 1 17 17 NUM dti-1410 109 2 . . PUNCT dti-1410 109 3 list list PROPN dti-1410 109 4 jf jf PROPN dti-1410 109 5 , , PUNCT dti-1410 109 6 whaley whaley PROPN dti-1410 109 7 jm jm PROPN dti-1410 109 8 . . PROPN dti-1410 109 9 glucose glucose NOUN dti-1410 109 10 dynamics dynamic NOUN dti-1410 109 11 and and CCONJ dti-1410 109 12 mechanistic mechanistic ADJ dti-1410 109 13 implications implication NOUN dti-1410 109 14 of of ADP dti-1410 109 15 sglt2 sglt2 ADJ dti-1410 109 16 inhibitors inhibitor NOUN dti-1410 109 17 in in ADP dti-1410 109 18 animals animal NOUN dti-1410 109 19 and and CCONJ dti-1410 109 20 humans human NOUN dti-1410 109 21 . . PUNCT dti-1410 110 1 kidney kidney NOUN dti-1410 110 2 int int NOUN dti-1410 110 3 . . PUNCT dti-1410 111 1 2011;79(suppl 2011;79(suppl NUM dti-1410 111 2 120):s20 120):s20 NUM dti-1410 111 3 – – PUNCT dti-1410 111 4 s27 s27 PROPN dti-1410 111 5 . . PUNCT dti-1410 111 6 http://www.la-press.com http://www.la-press.com X dti-1410 111 7 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN