id	sid	tid	token	lemma	pos
dti-1416	1	1	creative	creative	ADJ
dti-1416	1	2	commons	common	NOUN
dti-1416	1	3	cc	cc	ADP
dti-1416	1	4	by	by	ADP
dti-1416	1	5	:	:	PUNCT
dti-1416	1	6	this	this	DET
dti-1416	1	7	article	article	NOUN
dti-1416	1	8	is	be	AUX
dti-1416	1	9	distributed	distribute	VERB
dti-1416	1	10	under	under	ADP
dti-1416	1	11	the	the	DET
dti-1416	1	12	terms	term	NOUN
dti-1416	1	13	of	of	ADP
dti-1416	1	14	the	the	DET
dti-1416	1	15	creative	creative	ADJ
dti-1416	1	16	commons	common	NOUN
dti-1416	1	17	attribution	attribution	NOUN
dti-1416	1	18	4.0	4.0	NUM
dti-1416	1	19	license	license	NOUN
dti-1416	1	20	(	(	PUNCT
dti-1416	1	21	http://www.creativecommons.org/licenses/by/4.0/	http://www.creativecommons.org/licenses/by/4.0/	X
dti-1416	1	22	)	)	PUNCT
dti-1416	1	23	which	which	PRON
dti-1416	1	24	permits	permit	VERB
dti-1416	1	25	any	any	DET
dti-1416	1	26	use	use	NOUN
dti-1416	1	27	,	,	PUNCT
dti-1416	1	28	reproduction	reproduction	NOUN
dti-1416	1	29	and	and	CCONJ
dti-1416	1	30	distribution	distribution	NOUN
dti-1416	1	31	of	of	ADP
dti-1416	1	32	the	the	DET
dti-1416	1	33	work	work	NOUN
dti-1416	1	34	without	without	ADP
dti-1416	1	35	further	further	ADJ
dti-1416	1	36	permission	permission	NOUN
dti-1416	1	37	provided	provide	VERB
dti-1416	1	38	the	the	DET
dti-1416	1	39	original	original	ADJ
dti-1416	1	40	work	work	NOUN
dti-1416	1	41	is	be	AUX
dti-1416	1	42	attributed	attribute	VERB
dti-1416	1	43	as	as	ADP
dti-1416	1	44	specified	specify	VERB
dti-1416	1	45	on	on	ADP
dti-1416	1	46	the	the	DET
dti-1416	1	47	sage	sage	NOUN
dti-1416	1	48	and	and	CCONJ
dti-1416	1	49	open	open	ADJ
dti-1416	1	50	access	access	NOUN
dti-1416	1	51	pages	page	NOUN
dti-1416	1	52	(	(	PUNCT
dti-1416	1	53	https://us.sagepub.com/en-us/nam/open-access-at-sage	https://us.sagepub.com/en-us/nam/open-access-at-sage	NOUN
dti-1416	1	54	)	)	PUNCT
dti-1416	1	55	.	.	PUNCT
dti-1416	2	1	https://doi.org/10.1177/1177392819886875	https://doi.org/10.1177/1177392819886875	NOUN
dti-1416	2	2	drug	drug	NOUN
dti-1416	2	3	target	target	NOUN
dti-1416	2	4	insights	insight	NOUN
dti-1416	2	5	volume	volume	VERB
dti-1416	2	6	13	13	NUM
dti-1416	2	7	:	:	SYM
dti-1416	2	8	1–7	1–7	NUM
dti-1416	2	9	©	©	ADP
dti-1416	2	10	the	the	DET
dti-1416	2	11	author(s	author(s	PROPN
dti-1416	2	12	)	)	PUNCT
dti-1416	2	13	2019	2019	NUM
dti-1416	2	14	doi	doi	NOUN
dti-1416	2	15	:	:	PUNCT
dti-1416	2	16	10.1177/1177392819886875	10.1177/1177392819886875	NUM
dti-1416	2	17	we	we	PRON
dti-1416	2	18	are	be	AUX
dti-1416	2	19	at	at	ADP
dti-1416	2	20	a	a	DET
dti-1416	2	21	pivotal	pivotal	ADJ
dti-1416	2	22	moment	moment	NOUN
dti-1416	2	23	in	in	ADP
dti-1416	2	24	medical	medical	ADJ
dti-1416	2	25	science	science	NOUN
dti-1416	2	26	and	and	CCONJ
dti-1416	2	27	pharmacy	pharmacy	NOUN
dti-1416	2	28	practice	practice	NOUN
dti-1416	2	29	where	where	SCONJ
dti-1416	2	30	specific	specific	ADJ
dti-1416	2	31	variations	variation	NOUN
dti-1416	2	32	in	in	ADP
dti-1416	2	33	the	the	DET
dti-1416	2	34	genetic	genetic	ADJ
dti-1416	2	35	code	code	NOUN
dti-1416	2	36	are	be	AUX
dti-1416	2	37	being	be	AUX
dti-1416	2	38	associated	associate	VERB
dti-1416	2	39	with	with	ADP
dti-1416	2	40	differences	difference	NOUN
dti-1416	2	41	in	in	ADP
dti-1416	2	42	drug	drug	NOUN
dti-1416	2	43	response	response	NOUN
dti-1416	2	44	,	,	PUNCT
dti-1416	2	45	an	an	DET
dti-1416	2	46	individual	individual	NOUN
dti-1416	2	47	’s	’s	PART
dti-1416	2	48	propensity	propensity	NOUN
dti-1416	2	49	for	for	ADP
dti-1416	2	50	developing	develop	VERB
dti-1416	2	51	certain	certain	ADJ
dti-1416	2	52	drug	drug	NOUN
dti-1416	2	53	side	side	NOUN
dti-1416	2	54	effects	effect	NOUN
dti-1416	2	55	,	,	PUNCT
dti-1416	2	56	and	and	CCONJ
dti-1416	2	57	variation	variation	NOUN
dti-1416	2	58	in	in	ADP
dti-1416	2	59	the	the	DET
dti-1416	2	60	rate	rate	NOUN
dti-1416	2	61	and	and	CCONJ
dti-1416	2	62	extent	extent	NOUN
dti-1416	2	63	of	of	ADP
dti-1416	2	64	drug	drug	NOUN
dti-1416	2	65	metabolism	metabolism	NOUN
dti-1416	2	66	.	.	PUNCT
dti-1416	3	1	termed	term	VERB
dti-1416	3	2	pharmacogenomics	pharmacogenomic	NOUN
dti-1416	3	3	(	(	PUNCT
dti-1416	3	4	pgx	pgx	PROPN
dti-1416	3	5	)	)	PUNCT
dti-1416	3	6	,	,	PUNCT
dti-1416	3	7	this	this	DET
dti-1416	3	8	new	new	ADJ
dti-1416	3	9	discipline	discipline	NOUN
dti-1416	3	10	is	be	AUX
dti-1416	3	11	the	the	DET
dti-1416	3	12	study	study	NOUN
dti-1416	3	13	of	of	ADP
dti-1416	3	14	the	the	DET
dti-1416	3	15	interplay	interplay	NOUN
dti-1416	3	16	between	between	ADP
dti-1416	3	17	the	the	DET
dti-1416	3	18	human	human	ADJ
dti-1416	3	19	genome	genome	NOUN
dti-1416	3	20	and	and	CCONJ
dti-1416	3	21	the	the	DET
dti-1416	3	22	science	science	NOUN
dti-1416	3	23	of	of	ADP
dti-1416	3	24	pharmacology.1	pharmacology.1	NOUN
dti-1416	3	25	the	the	DET
dti-1416	3	26	curriculums	curriculum	NOUN
dti-1416	3	27	of	of	ADP
dti-1416	3	28	most	most	ADJ
dti-1416	3	29	pharmacy	pharmacy	NOUN
dti-1416	3	30	schools	school	NOUN
dti-1416	3	31	have	have	AUX
dti-1416	3	32	only	only	ADV
dti-1416	3	33	recently	recently	ADV
dti-1416	3	34	included	include	VERB
dti-1416	3	35	coursework	coursework	NOUN
dti-1416	3	36	in	in	ADP
dti-1416	3	37	genetics	genetic	NOUN
dti-1416	3	38	and	and	CCONJ
dti-1416	3	39	pgx	pgx	PROPN
dti-1416	3	40	.	.	PUNCT
dti-1416	4	1	pharmacists	pharmacist	NOUN
dti-1416	4	2	educated	educate	VERB
dti-1416	4	3	in	in	ADP
dti-1416	4	4	the	the	DET
dti-1416	4	5	past	past	NOUN
dti-1416	4	6	may	may	AUX
dti-1416	4	7	have	have	AUX
dti-1416	4	8	had	have	VERB
dti-1416	4	9	little	little	ADJ
dti-1416	4	10	exposure	exposure	NOUN
dti-1416	4	11	to	to	ADP
dti-1416	4	12	the	the	DET
dti-1416	4	13	genetic	genetic	ADJ
dti-1416	4	14	principles	principle	NOUN
dti-1416	4	15	underlying	underlie	VERB
dti-1416	4	16	pgx	pgx	PROPN
dti-1416	4	17	.	.	PUNCT
dti-1416	5	1	the	the	DET
dti-1416	5	2	intent	intent	NOUN
dti-1416	5	3	of	of	ADP
dti-1416	5	4	this	this	DET
dti-1416	5	5	review	review	NOUN
dti-1416	5	6	is	be	AUX
dti-1416	5	7	to	to	PART
dti-1416	5	8	present	present	VERB
dti-1416	5	9	basic	basic	ADJ
dti-1416	5	10	concepts	concept	NOUN
dti-1416	5	11	in	in	ADP
dti-1416	5	12	genetics	genetic	NOUN
dti-1416	5	13	and	and	CCONJ
dti-1416	5	14	genetic	genetic	ADJ
dti-1416	5	15	variation	variation	NOUN
dti-1416	5	16	to	to	PART
dti-1416	5	17	provide	provide	VERB
dti-1416	5	18	a	a	DET
dti-1416	5	19	foundation	foundation	NOUN
dti-1416	5	20	for	for	ADP
dti-1416	5	21	understanding	understand	VERB
dti-1416	5	22	important	important	ADJ
dti-1416	5	23	and	and	CCONJ
dti-1416	5	24	highly	highly	ADV
dti-1416	5	25	evidenced	evidence	VERB
dti-1416	5	26	gene	gene	NOUN
dti-1416	5	27	-	-	PUNCT
dti-1416	5	28	drug	drug	NOUN
dti-1416	5	29	associations	association	NOUN
dti-1416	5	30	.	.	PUNCT
dti-1416	6	1	whenever	whenever	SCONJ
dti-1416	6	2	possible	possible	ADJ
dti-1416	6	3	,	,	PUNCT
dti-1416	6	4	the	the	DET
dti-1416	6	5	examples	example	NOUN
dti-1416	6	6	used	use	VERB
dti-1416	6	7	will	will	AUX
dti-1416	6	8	include	include	VERB
dti-1416	6	9	medications	medication	NOUN
dti-1416	6	10	where	where	SCONJ
dti-1416	6	11	genetic	genetic	ADJ
dti-1416	6	12	testing	testing	NOUN
dti-1416	6	13	is	be	AUX
dti-1416	6	14	recommended	recommend	VERB
dti-1416	6	15	by	by	ADP
dti-1416	6	16	the	the	DET
dti-1416	6	17	us	us	PROPN
dti-1416	6	18	food	food	NOUN
dti-1416	6	19	and	and	CCONJ
dti-1416	6	20	drug	drug	PROPN
dti-1416	6	21	administration	administration	PROPN
dti-1416	6	22	(	(	PUNCT
dti-1416	6	23	fda	fda	PROPN
dti-1416	6	24	)	)	PUNCT
dti-1416	6	25	labeling	labeling	NOUN
dti-1416	6	26	or	or	CCONJ
dti-1416	6	27	expert	expert	VERB
dti-1416	6	28	clinical	clinical	ADJ
dti-1416	6	29	practice	practice	NOUN
dti-1416	6	30	guidelines	guideline	NOUN
dti-1416	6	31	.	.	PUNCT
dti-1416	7	1	several	several	ADJ
dti-1416	7	2	reliable	reliable	ADJ
dti-1416	7	3	,	,	PUNCT
dti-1416	7	4	online	online	PROPN
dti-1416	7	5	pgx	pgx	PROPN
dti-1416	7	6	references	reference	NOUN
dti-1416	7	7	will	will	AUX
dti-1416	7	8	also	also	ADV
dti-1416	7	9	be	be	AUX
dti-1416	7	10	presented	present	VERB
dti-1416	7	11	.	.	PUNCT
dti-1416	8	1	as	as	ADP
dti-1416	8	2	pharmacists	pharmacist	NOUN
dti-1416	8	3	and	and	CCONJ
dti-1416	8	4	scientists	scientist	NOUN
dti-1416	8	5	,	,	PUNCT
dti-1416	8	6	the	the	DET
dti-1416	8	7	time	time	NOUN
dti-1416	8	8	is	be	AUX
dti-1416	8	9	now	now	ADV
dti-1416	8	10	to	to	PART
dti-1416	8	11	embrace	embrace	VERB
dti-1416	8	12	these	these	DET
dti-1416	8	13	ensuing	ensue	VERB
dti-1416	8	14	advancements	advancement	NOUN
dti-1416	8	15	in	in	ADP
dti-1416	8	16	drug	drug	NOUN
dti-1416	8	17	therapy	therapy	NOUN
dti-1416	8	18	and	and	CCONJ
dti-1416	8	19	prepare	prepare	VERB
dti-1416	8	20	ourselves	ourselves	PRON
dti-1416	8	21	to	to	PART
dti-1416	8	22	translate	translate	VERB
dti-1416	8	23	gene	gene	NOUN
dti-1416	8	24	-	-	PUNCT
dti-1416	8	25	drug	drug	NOUN
dti-1416	8	26	associations	association	NOUN
dti-1416	8	27	into	into	ADP
dti-1416	8	28	clinical	clinical	ADJ
dti-1416	8	29	practice	practice	NOUN
dti-1416	8	30	.	.	PUNCT
dti-1416	9	1	pharmacogenomics	pharmacogenomic	NOUN
dti-1416	9	2	was	be	AUX
dti-1416	9	3	born	bear	VERB
dti-1416	9	4	out	out	ADP
dti-1416	9	5	of	of	ADP
dti-1416	9	6	the	the	DET
dti-1416	9	7	findings	finding	NOUN
dti-1416	9	8	from	from	ADP
dti-1416	9	9	the	the	DET
dti-1416	9	10	human	human	ADJ
dti-1416	9	11	genome	genome	NOUN
dti-1416	9	12	project	project	NOUN
dti-1416	9	13	(	(	PUNCT
dti-1416	9	14	hgp	hgp	PROPN
dti-1416	9	15	;	;	PUNCT
dti-1416	9	16	www.genome.gov).2	www.genome.gov).2	PROPN
dti-1416	9	17	launched	launch	VERB
dti-1416	9	18	in	in	ADP
dti-1416	9	19	1990	1990	NUM
dti-1416	9	20	,	,	PUNCT
dti-1416	9	21	the	the	DET
dti-1416	9	22	hgp	hgp	PROPN
dti-1416	9	23	was	be	AUX
dti-1416	9	24	an	an	DET
dti-1416	9	25	international	international	ADJ
dti-1416	9	26	effort	effort	NOUN
dti-1416	9	27	to	to	PART
dti-1416	9	28	identify	identify	VERB
dti-1416	9	29	and	and	CCONJ
dti-1416	9	30	understand	understand	VERB
dti-1416	9	31	the	the	DET
dti-1416	9	32	structure	structure	NOUN
dti-1416	9	33	of	of	ADP
dti-1416	9	34	every	every	DET
dti-1416	9	35	gene	gene	NOUN
dti-1416	9	36	human	human	ADJ
dti-1416	9	37	beings	being	NOUN
dti-1416	9	38	possess	possess	VERB
dti-1416	9	39	.	.	PUNCT
dti-1416	10	1	the	the	DET
dti-1416	10	2	hgp	hgp	PROPN
dti-1416	10	3	will	will	AUX
dti-1416	10	4	no	no	ADV
dti-1416	10	5	doubt	doubt	ADV
dti-1416	10	6	be	be	AUX
dti-1416	10	7	viewed	view	VERB
dti-1416	10	8	as	as	ADP
dti-1416	10	9	the	the	DET
dti-1416	10	10	greatest	great	ADJ
dti-1416	10	11	scientific	scientific	ADJ
dti-1416	10	12	advancement	advancement	NOUN
dti-1416	10	13	of	of	ADP
dti-1416	10	14	our	our	PRON
dti-1416	10	15	lifetime	lifetime	NOUN
dti-1416	10	16	and	and	CCONJ
dti-1416	10	17	will	will	AUX
dti-1416	10	18	have	have	VERB
dti-1416	10	19	a	a	DET
dti-1416	10	20	profound	profound	ADJ
dti-1416	10	21	impact	impact	NOUN
dti-1416	10	22	on	on	ADP
dti-1416	10	23	medical	medical	ADJ
dti-1416	10	24	science	science	NOUN
dti-1416	10	25	and	and	CCONJ
dti-1416	10	26	the	the	DET
dti-1416	10	27	practice	practice	NOUN
dti-1416	10	28	of	of	ADP
dti-1416	10	29	pharmacy	pharmacy	NOUN
dti-1416	10	30	.	.	PUNCT
dti-1416	11	1	the	the	DET
dti-1416	11	2	main	main	ADJ
dti-1416	11	3	mission	mission	NOUN
dti-1416	11	4	of	of	ADP
dti-1416	11	5	the	the	DET
dti-1416	11	6	project	project	NOUN
dti-1416	11	7	was	be	AUX
dti-1416	11	8	to	to	PART
dti-1416	11	9	crack	crack	VERB
dti-1416	11	10	the	the	DET
dti-1416	11	11	human	human	ADJ
dti-1416	11	12	genetic	genetic	ADJ
dti-1416	11	13	code	code	NOUN
dti-1416	11	14	by	by	ADP
dti-1416	11	15	combining	combine	VERB
dti-1416	11	16	the	the	DET
dti-1416	11	17	power	power	NOUN
dti-1416	11	18	of	of	ADP
dti-1416	11	19	scientists	scientist	NOUN
dti-1416	11	20	from	from	ADP
dti-1416	11	21	universities	university	NOUN
dti-1416	11	22	and	and	CCONJ
dti-1416	11	23	research	research	NOUN
dti-1416	11	24	centers	center	NOUN
dti-1416	11	25	in	in	ADP
dti-1416	11	26	the	the	DET
dti-1416	11	27	united	united	PROPN
dti-1416	11	28	states	states	PROPN
dti-1416	11	29	,	,	PUNCT
dti-1416	11	30	the	the	DET
dti-1416	11	31	united	united	PROPN
dti-1416	11	32	kingdom	kingdom	PROPN
dti-1416	11	33	,	,	PUNCT
dti-1416	11	34	france	france	PROPN
dti-1416	11	35	,	,	PUNCT
dti-1416	11	36	germany	germany	PROPN
dti-1416	11	37	,	,	PUNCT
dti-1416	11	38	japan	japan	PROPN
dti-1416	11	39	,	,	PUNCT
dti-1416	11	40	and	and	CCONJ
dti-1416	11	41	china	china	PROPN
dti-1416	11	42	.	.	PUNCT
dti-1416	12	1	this	this	DET
dti-1416	12	2	worldwide	worldwide	ADJ
dti-1416	12	3	endeavor	endeavor	NOUN
dti-1416	12	4	stands	stand	VERB
dti-1416	12	5	as	as	ADP
dti-1416	12	6	a	a	DET
dti-1416	12	7	testimony	testimony	NOUN
dti-1416	12	8	to	to	ADP
dti-1416	12	9	the	the	DET
dti-1416	12	10	greater	great	ADJ
dti-1416	12	11	good	good	NOUN
dti-1416	12	12	that	that	PRON
dti-1416	12	13	can	can	AUX
dti-1416	12	14	be	be	AUX
dti-1416	12	15	achieved	achieve	VERB
dti-1416	12	16	when	when	SCONJ
dti-1416	12	17	researchers	researcher	NOUN
dti-1416	12	18	work	work	VERB
dti-1416	12	19	together	together	ADV
dti-1416	12	20	to	to	PART
dti-1416	12	21	accomplish	accomplish	VERB
dti-1416	12	22	a	a	DET
dti-1416	12	23	common	common	ADJ
dti-1416	12	24	goal	goal	NOUN
dti-1416	12	25	.	.	PUNCT
dti-1416	13	1	the	the	DET
dti-1416	13	2	sequencing	sequencing	NOUN
dti-1416	13	3	or	or	CCONJ
dti-1416	13	4	mapping	mapping	NOUN
dti-1416	13	5	of	of	ADP
dti-1416	13	6	the	the	DET
dti-1416	13	7	2.91	2.91	NUM
dti-1416	13	8	billion	billion	NUM
dti-1416	13	9	base	base	NOUN
dti-1416	13	10	pairs	pair	NOUN
dti-1416	13	11	that	that	PRON
dti-1416	13	12	spell	spell	VERB
dti-1416	13	13	out	out	ADP
dti-1416	13	14	the	the	DET
dti-1416	13	15	genetic	genetic	ADJ
dti-1416	13	16	blueprint	blueprint	NOUN
dti-1416	13	17	within	within	ADP
dti-1416	13	18	the	the	DET
dti-1416	13	19	molecule	molecule	NOUN
dti-1416	13	20	called	call	VERB
dti-1416	13	21	deoxyribonucleic	deoxyribonucleic	ADJ
dti-1416	13	22	acid	acid	NOUN
dti-1416	13	23	(	(	PUNCT
dti-1416	13	24	dna	dna	PROPN
dti-1416	13	25	)	)	PUNCT
dti-1416	13	26	was	be	AUX
dti-1416	13	27	completed	complete	VERB
dti-1416	13	28	years	year	NOUN
dti-1416	13	29	ahead	ahead	ADV
dti-1416	13	30	of	of	ADP
dti-1416	13	31	schedule	schedule	NOUN
dti-1416	13	32	in	in	ADP
dti-1416	13	33	april	april	PROPN
dti-1416	13	34	of	of	ADP
dti-1416	13	35	2003	2003	NUM
dti-1416	13	36	.	.	PUNCT
dti-1416	14	1	the	the	DET
dti-1416	14	2	entire	entire	ADJ
dti-1416	14	3	code	code	NOUN
dti-1416	14	4	is	be	AUX
dti-1416	14	5	known	know	VERB
dti-1416	14	6	as	as	ADP
dti-1416	14	7	the	the	DET
dti-1416	14	8	human	human	ADJ
dti-1416	14	9	genome	genome	NOUN
dti-1416	14	10	and	and	CCONJ
dti-1416	14	11	is	be	AUX
dti-1416	14	12	housed	house	VERB
dti-1416	14	13	in	in	ADP
dti-1416	14	14	the	the	DET
dti-1416	14	15	nucleus	nucleus	NOUN
dti-1416	14	16	of	of	ADP
dti-1416	14	17	nearly	nearly	ADV
dti-1416	14	18	every	every	PRON
dti-1416	14	19	human	human	ADJ
dti-1416	14	20	cell	cell	NOUN
dti-1416	14	21	.	.	PUNCT
dti-1416	15	1	research	research	NOUN
dti-1416	15	2	to	to	PART
dti-1416	15	3	discover	discover	VERB
dti-1416	15	4	how	how	SCONJ
dti-1416	15	5	variation	variation	NOUN
dti-1416	15	6	and	and	CCONJ
dti-1416	15	7	expression	expression	NOUN
dti-1416	15	8	of	of	ADP
dti-1416	15	9	this	this	DET
dti-1416	15	10	code	code	NOUN
dti-1416	15	11	influence	influence	NOUN
dti-1416	15	12	human	human	ADJ
dti-1416	15	13	health	health	NOUN
dti-1416	15	14	is	be	AUX
dti-1416	15	15	just	just	ADV
dti-1416	15	16	beginning.3	beginning.3	ADP
dti-1416	15	17	the	the	DET
dti-1416	15	18	hgp	hgp	NOUN
dti-1416	15	19	has	have	AUX
dti-1416	15	20	given	give	VERB
dti-1416	15	21	rise	rise	NOUN
dti-1416	15	22	to	to	ADP
dti-1416	15	23	truly	truly	ADV
dti-1416	15	24	personalized	personalize	VERB
dti-1416	15	25	medicine	medicine	NOUN
dti-1416	15	26	,	,	PUNCT
dti-1416	15	27	which	which	PRON
dti-1416	15	28	relates	relate	VERB
dti-1416	15	29	markers	marker	NOUN
dti-1416	15	30	or	or	CCONJ
dti-1416	15	31	patterns	pattern	NOUN
dti-1416	15	32	in	in	ADP
dti-1416	15	33	an	an	DET
dti-1416	15	34	individual	individual	NOUN
dti-1416	15	35	’s	’s	PART
dti-1416	15	36	dna	dna	PROPN
dti-1416	15	37	sequence	sequence	NOUN
dti-1416	15	38	to	to	ADP
dti-1416	15	39	the	the	DET
dti-1416	15	40	causation	causation	NOUN
dti-1416	15	41	and	and	CCONJ
dti-1416	15	42	treatment	treatment	NOUN
dti-1416	15	43	of	of	ADP
dti-1416	15	44	disease	disease	NOUN
dti-1416	15	45	.	.	PUNCT
dti-1416	16	1	pharmacists	pharmacist	NOUN
dti-1416	16	2	are	be	AUX
dti-1416	16	3	the	the	DET
dti-1416	16	4	ideal	ideal	ADJ
dti-1416	16	5	practitioners	practitioner	NOUN
dti-1416	16	6	to	to	PART
dti-1416	16	7	implement	implement	VERB
dti-1416	16	8	pgxguided	pgxguide	VERB
dti-1416	16	9	drug	drug	NOUN
dti-1416	16	10	therapy	therapy	NOUN
dti-1416	16	11	and	and	CCONJ
dti-1416	16	12	to	to	PART
dti-1416	16	13	translate	translate	VERB
dti-1416	16	14	gene	gene	NOUN
dti-1416	16	15	-	-	PUNCT
dti-1416	16	16	drug	drug	NOUN
dti-1416	16	17	associations	association	NOUN
dti-1416	16	18	into	into	ADP
dti-1416	16	19	clinical	clinical	ADJ
dti-1416	16	20	practice	practice	NOUN
dti-1416	16	21	.	.	PUNCT
dti-1416	17	1	pharmacists	pharmacist	NOUN
dti-1416	17	2	will	will	AUX
dti-1416	17	3	be	be	AUX
dti-1416	17	4	needed	need	VERB
dti-1416	17	5	to	to	PART
dti-1416	17	6	personalize	personalize	VERB
dti-1416	17	7	the	the	DET
dti-1416	17	8	selection	selection	NOUN
dti-1416	17	9	and	and	CCONJ
dti-1416	17	10	dosing	dosing	NOUN
dti-1416	17	11	of	of	ADP
dti-1416	17	12	medications	medication	NOUN
dti-1416	17	13	and	and	CCONJ
dti-1416	17	14	explain	explain	VERB
dti-1416	17	15	pgx	pgx	PROPN
dti-1416	17	16	risk	risk	NOUN
dti-1416	17	17	information	information	NOUN
dti-1416	17	18	to	to	ADP
dti-1416	17	19	both	both	DET
dti-1416	17	20	patients	patient	NOUN
dti-1416	17	21	and	and	CCONJ
dti-1416	17	22	providers	provider	NOUN
dti-1416	17	23	.	.	PUNCT
dti-1416	18	1	the	the	DET
dti-1416	18	2	intent	intent	NOUN
dti-1416	18	3	of	of	ADP
dti-1416	18	4	this	this	DET
dti-1416	18	5	review	review	NOUN
dti-1416	18	6	is	be	AUX
dti-1416	18	7	to	to	PART
dti-1416	18	8	open	open	VERB
dti-1416	18	9	a	a	DET
dti-1416	18	10	window	window	NOUN
dti-1416	18	11	into	into	ADP
dti-1416	18	12	the	the	DET
dti-1416	18	13	future	future	NOUN
dti-1416	18	14	of	of	ADP
dti-1416	18	15	drug	drug	NOUN
dti-1416	18	16	therapy	therapy	NOUN
dti-1416	18	17	by	by	ADP
dti-1416	18	18	presenting	present	VERB
dti-1416	18	19	the	the	DET
dti-1416	18	20	basic	basic	ADJ
dti-1416	18	21	terminology	terminology	NOUN
dti-1416	18	22	and	and	CCONJ
dti-1416	18	23	concepts	concept	NOUN
dti-1416	18	24	of	of	ADP
dti-1416	18	25	pgx	pgx	PROPN
dti-1416	18	26	and	and	CCONJ
dti-1416	18	27	provide	provide	VERB
dti-1416	18	28	educational	educational	ADJ
dti-1416	18	29	resources	resource	NOUN
dti-1416	18	30	that	that	PRON
dti-1416	18	31	will	will	AUX
dti-1416	18	32	help	help	VERB
dti-1416	18	33	you	you	PRON
dti-1416	18	34	remain	remain	VERB
dti-1416	18	35	up	up	ADP
dti-1416	18	36	to	to	ADP
dti-1416	18	37	date	date	NOUN
dti-1416	18	38	with	with	ADP
dti-1416	18	39	these	these	DET
dti-1416	18	40	emerging	emerge	VERB
dti-1416	18	41	changes	change	NOUN
dti-1416	18	42	in	in	ADP
dti-1416	18	43	medical	medical	ADJ
dti-1416	18	44	science	science	NOUN
dti-1416	18	45	and	and	CCONJ
dti-1416	18	46	medication	medication	NOUN
dti-1416	18	47	management	management	NOUN
dti-1416	18	48	.	.	PUNCT
dti-1416	19	1	dna	dna	PROPN
dti-1416	19	2	,	,	PUNCT
dti-1416	19	3	chromosomes	chromosome	NOUN
dti-1416	19	4	,	,	PUNCT
dti-1416	19	5	and	and	CCONJ
dti-1416	19	6	genes	gene	VERB
dti-1416	19	7	a	a	DET
dti-1416	19	8	foundational	foundational	ADJ
dti-1416	19	9	concept	concept	NOUN
dti-1416	19	10	to	to	PART
dti-1416	19	11	keep	keep	VERB
dti-1416	19	12	in	in	ADP
dti-1416	19	13	mind	mind	NOUN
dti-1416	19	14	is	be	AUX
dti-1416	19	15	that	that	SCONJ
dti-1416	19	16	genes	gene	NOUN
dti-1416	19	17	,	,	PUNCT
dti-1416	19	18	which	which	PRON
dti-1416	19	19	are	be	AUX
dti-1416	19	20	stretches	stretch	NOUN
dti-1416	19	21	of	of	ADP
dti-1416	19	22	dna	dna	PROPN
dti-1416	19	23	,	,	PUNCT
dti-1416	19	24	determine	determine	VERB
dti-1416	19	25	the	the	DET
dti-1416	19	26	composition	composition	NOUN
dti-1416	19	27	,	,	PUNCT
dti-1416	19	28	size	size	NOUN
dti-1416	19	29	,	,	PUNCT
dti-1416	19	30	and	and	CCONJ
dti-1416	19	31	shape	shape	NOUN
dti-1416	19	32	of	of	ADP
dti-1416	19	33	every	every	DET
dti-1416	19	34	protein	protein	NOUN
dti-1416	19	35	a	a	DET
dti-1416	19	36	living	live	VERB
dti-1416	19	37	organism	organism	NOUN
dti-1416	19	38	builds	build	VERB
dti-1416	19	39	.	.	PUNCT
dti-1416	20	1	one	one	NUM
dti-1416	20	2	gene	gene	NOUN
dti-1416	20	3	may	may	AUX
dti-1416	20	4	hold	hold	VERB
dti-1416	20	5	the	the	DET
dti-1416	20	6	“	"	PUNCT
dti-1416	20	7	recipe	recipe	NOUN
dti-1416	20	8	”	"	PUNCT
dti-1416	20	9	for	for	ADP
dti-1416	20	10	one	one	NUM
dti-1416	20	11	or	or	CCONJ
dti-1416	20	12	hundreds	hundred	NOUN
dti-1416	20	13	of	of	ADP
dti-1416	20	14	different	different	ADJ
dti-1416	20	15	proteins	protein	NOUN
dti-1416	20	16	.	.	PUNCT
dti-1416	21	1	an	an	DET
dti-1416	21	2	effort	effort	NOUN
dti-1416	21	3	to	to	PART
dti-1416	21	4	identify	identify	VERB
dti-1416	21	5	every	every	DET
dti-1416	21	6	protein	protein	NOUN
dti-1416	21	7	human	human	ADJ
dti-1416	21	8	beings	being	NOUN
dti-1416	21	9	produce	produce	VERB
dti-1416	21	10	called	call	VERB
dti-1416	21	11	the	the	DET
dti-1416	21	12	human	human	ADJ
dti-1416	21	13	proteome	proteome	PROPN
dti-1416	21	14	project	project	NOUN
dti-1416	21	15	is	be	AUX
dti-1416	21	16	also	also	ADV
dti-1416	21	17	underway	underway	ADJ
dti-1416	21	18	and	and	CCONJ
dti-1416	21	19	once	once	ADV
dti-1416	21	20	completed	complete	VERB
dti-1416	21	21	humans	human	NOUN
dti-1416	21	22	are	be	AUX
dti-1416	21	23	estimated	estimate	VERB
dti-1416	21	24	to	to	PART
dti-1416	21	25	make	make	VERB
dti-1416	21	26	approximately	approximately	ADV
dti-1416	21	27	250	250	NUM
dti-1416	21	28	000	000	NUM
dti-1416	21	29	to	to	ADP
dti-1416	21	30	1	1	NUM
dti-1416	21	31	million	million	NUM
dti-1416	21	32	different	different	ADJ
dti-1416	21	33	proteins.4	proteins.4	NOUN
dti-1416	21	34	as	as	ADP
dti-1416	21	35	enzymes	enzyme	NOUN
dti-1416	21	36	,	,	PUNCT
dti-1416	21	37	transporters	transporter	NOUN
dti-1416	21	38	,	,	PUNCT
dti-1416	21	39	drug	drug	NOUN
dti-1416	21	40	receptor	receptor	NOUN
dti-1416	21	41	,	,	PUNCT
dti-1416	21	42	binding	bind	VERB
dti-1416	21	43	sites	site	NOUN
dti-1416	21	44	,	,	PUNCT
dti-1416	21	45	cell	cell	NOUN
dti-1416	21	46	structural	structural	ADJ
dti-1416	21	47	components	component	NOUN
dti-1416	21	48	,	,	PUNCT
dti-1416	21	49	and	and	CCONJ
dti-1416	21	50	peptide	peptide	ADJ
dti-1416	21	51	hormones	hormone	NOUN
dti-1416	21	52	,	,	PUNCT
dti-1416	21	53	protein	protein	NOUN
dti-1416	21	54	molecules	molecule	NOUN
dti-1416	21	55	are	be	AUX
dti-1416	21	56	central	central	ADJ
dti-1416	21	57	to	to	ADP
dti-1416	21	58	nearly	nearly	ADV
dti-1416	21	59	every	every	PRON
dti-1416	21	60	biochemical	biochemical	ADJ
dti-1416	21	61	and	and	CCONJ
dti-1416	21	62	pharmacological	pharmacological	ADJ
dti-1416	21	63	reaction	reaction	NOUN
dti-1416	21	64	.	.	PUNCT
dti-1416	22	1	basic	basic	ADJ
dti-1416	22	2	concepts	concept	NOUN
dti-1416	22	3	in	in	ADP
dti-1416	22	4	genetics	genetic	NOUN
dti-1416	22	5	and	and	CCONJ
dti-1416	22	6	pharmacogenomics	pharmacogenomic	NOUN
dti-1416	22	7	for	for	ADP
dti-1416	22	8	pharmacists	pharmacist	NOUN
dti-1416	22	9	kathleen	kathleen	PROPN
dti-1416	22	10	b	b	PROPN
dti-1416	23	1	orrico1,2	orrico1,2	PROPN
dti-1416	23	2	1school	1school	NUM
dti-1416	23	3	of	of	ADP
dti-1416	23	4	pharmacy	pharmacy	NOUN
dti-1416	23	5	,	,	PUNCT
dti-1416	23	6	university	university	PROPN
dti-1416	23	7	of	of	ADP
dti-1416	23	8	california	california	PROPN
dti-1416	23	9	,	,	PUNCT
dti-1416	23	10	san	san	PROPN
dti-1416	23	11	francisco	francisco	PROPN
dti-1416	23	12	,	,	PUNCT
dti-1416	23	13	san	san	PROPN
dti-1416	23	14	francisco	francisco	PROPN
dti-1416	23	15	,	,	PUNCT
dti-1416	23	16	ca	ca	PROPN
dti-1416	23	17	,	,	PUNCT
dti-1416	23	18	usa	usa	PROPN
dti-1416	23	19	.	.	PROPN
dti-1416	23	20	2center	2center	NUM
dti-1416	23	21	for	for	ADP
dti-1416	23	22	clinical	clinical	ADJ
dti-1416	23	23	research	research	NOUN
dti-1416	23	24	,	,	PUNCT
dti-1416	23	25	stanford	stanford	PROPN
dti-1416	23	26	university	university	PROPN
dti-1416	23	27	school	school	NOUN
dti-1416	23	28	of	of	ADP
dti-1416	23	29	medicine	medicine	NOUN
dti-1416	23	30	,	,	PUNCT
dti-1416	23	31	stanford	stanford	PROPN
dti-1416	23	32	,	,	PUNCT
dti-1416	23	33	ca	ca	PROPN
dti-1416	23	34	,	,	PUNCT
dti-1416	23	35	usa	usa	PROPN
dti-1416	23	36	.	.	PROPN
dti-1416	23	37	abstract	abstract	PROPN
dti-1416	23	38	:	:	PUNCT
dti-1416	23	39	this	this	DET
dti-1416	23	40	basic	basic	ADJ
dti-1416	23	41	review	review	NOUN
dti-1416	23	42	of	of	ADP
dti-1416	23	43	genetic	genetic	ADJ
dti-1416	23	44	principles	principle	NOUN
dti-1416	23	45	will	will	AUX
dti-1416	23	46	aid	aid	VERB
dti-1416	23	47	pharmacists	pharmacist	NOUN
dti-1416	23	48	in	in	ADP
dti-1416	23	49	preparing	prepare	VERB
dti-1416	23	50	for	for	ADP
dti-1416	23	51	their	their	PRON
dti-1416	23	52	eventual	eventual	ADJ
dti-1416	23	53	role	role	NOUN
dti-1416	23	54	of	of	ADP
dti-1416	23	55	translating	translate	VERB
dti-1416	23	56	gene	gene	NOUN
dti-1416	23	57	-	-	PUNCT
dti-1416	23	58	drug	drug	NOUN
dti-1416	23	59	associations	association	NOUN
dti-1416	23	60	into	into	ADP
dti-1416	23	61	clinical	clinical	ADJ
dti-1416	23	62	practice	practice	NOUN
dti-1416	23	63	.	.	PUNCT
dti-1416	24	1	genes	gene	NOUN
dti-1416	24	2	,	,	PUNCT
dti-1416	24	3	which	which	PRON
dti-1416	24	4	are	be	AUX
dti-1416	24	5	stretches	stretch	NOUN
dti-1416	24	6	of	of	ADP
dti-1416	24	7	deoxyribonucleic	deoxyribonucleic	ADJ
dti-1416	24	8	acid	acid	NOUN
dti-1416	24	9	(	(	PUNCT
dti-1416	24	10	dna	dna	PROPN
dti-1416	24	11	)	)	PUNCT
dti-1416	24	12	contained	contain	VERB
dti-1416	24	13	on	on	ADP
dti-1416	24	14	the	the	DET
dti-1416	24	15	23	23	NUM
dti-1416	24	16	pairs	pair	NOUN
dti-1416	24	17	of	of	ADP
dti-1416	24	18	human	human	ADJ
dti-1416	24	19	chromosomes	chromosome	NOUN
dti-1416	24	20	,	,	PUNCT
dti-1416	24	21	determine	determine	VERB
dti-1416	24	22	the	the	DET
dti-1416	24	23	size	size	NOUN
dti-1416	24	24	and	and	CCONJ
dti-1416	24	25	shape	shape	NOUN
dti-1416	24	26	of	of	ADP
dti-1416	24	27	every	every	DET
dti-1416	24	28	protein	protein	NOUN
dti-1416	24	29	a	a	DET
dti-1416	24	30	living	live	VERB
dti-1416	24	31	organism	organism	NOUN
dti-1416	24	32	builds	build	VERB
dti-1416	24	33	.	.	PUNCT
dti-1416	25	1	variation	variation	NOUN
dti-1416	25	2	in	in	ADP
dti-1416	25	3	pharmacogenes	pharmacogene	NOUN
dti-1416	25	4	which	which	PRON
dti-1416	25	5	encode	encode	VERB
dti-1416	25	6	for	for	ADP
dti-1416	25	7	proteins	protein	NOUN
dti-1416	25	8	central	central	ADJ
dti-1416	25	9	to	to	ADP
dti-1416	25	10	drug	drug	NOUN
dti-1416	25	11	action	action	NOUN
dti-1416	25	12	and	and	CCONJ
dti-1416	25	13	toxicity	toxicity	NOUN
dti-1416	25	14	serves	serve	VERB
dti-1416	25	15	as	as	ADP
dti-1416	25	16	the	the	DET
dti-1416	25	17	basis	basis	NOUN
dti-1416	25	18	of	of	ADP
dti-1416	25	19	pharmacogenomics	pharmacogenomic	NOUN
dti-1416	25	20	(	(	PUNCT
dti-1416	25	21	pgx	pgx	PROPN
dti-1416	25	22	)	)	PUNCT
dti-1416	25	23	.	.	PUNCT
dti-1416	26	1	important	important	ADJ
dti-1416	26	2	online	online	ADJ
dti-1416	26	3	resources	resource	NOUN
dti-1416	26	4	such	such	ADJ
dti-1416	26	5	as	as	ADP
dti-1416	26	6	pharmgkb.org	pharmgkb.org	NOUN
dti-1416	26	7	,	,	PUNCT
dti-1416	26	8	cpicpgx.org	cpicpgx.org	X
dti-1416	26	9	,	,	PUNCT
dti-1416	26	10	and	and	CCONJ
dti-1416	26	11	pharmvar.org	pharmvar.org	NOUN
dti-1416	26	12	provide	provide	VERB
dti-1416	26	13	the	the	DET
dti-1416	26	14	clinician	clinician	NOUN
dti-1416	26	15	with	with	ADP
dti-1416	26	16	curated	curate	VERB
dti-1416	26	17	and	and	CCONJ
dti-1416	26	18	summarized	summarize	VERB
dti-1416	26	19	pgx	pgx	PROPN
dti-1416	26	20	associations	association	NOUN
dti-1416	26	21	and	and	CCONJ
dti-1416	26	22	clinical	clinical	ADJ
dti-1416	26	23	guidelines	guideline	NOUN
dti-1416	26	24	.	.	PUNCT
dti-1416	27	1	as	as	SCONJ
dti-1416	27	2	genetic	genetic	ADJ
dti-1416	27	3	testing	testing	NOUN
dti-1416	27	4	becomes	become	VERB
dti-1416	27	5	increasingly	increasingly	ADV
dti-1416	27	6	affordable	affordable	ADJ
dti-1416	27	7	and	and	CCONJ
dti-1416	27	8	accessible	accessible	ADJ
dti-1416	27	9	,	,	PUNCT
dti-1416	27	10	the	the	DET
dti-1416	27	11	time	time	NOUN
dti-1416	27	12	is	be	AUX
dti-1416	27	13	now	now	ADV
dti-1416	27	14	for	for	SCONJ
dti-1416	27	15	pharmacists	pharmacist	NOUN
dti-1416	27	16	to	to	PART
dti-1416	27	17	embrace	embrace	VERB
dti-1416	27	18	pgx	pgx	PROPN
dti-1416	27	19	-	-	PUNCT
dti-1416	27	20	guided	guide	VERB
dti-1416	27	21	medication	medication	NOUN
dti-1416	27	22	selection	selection	NOUN
dti-1416	27	23	and	and	CCONJ
dti-1416	27	24	dosing	dose	VERB
dti-1416	27	25	to	to	PART
dti-1416	27	26	personalize	personalize	VERB
dti-1416	27	27	and	and	CCONJ
dti-1416	27	28	improve	improve	VERB
dti-1416	27	29	the	the	DET
dti-1416	27	30	safety	safety	NOUN
dti-1416	27	31	and	and	CCONJ
dti-1416	27	32	efficacy	efficacy	NOUN
dti-1416	27	33	of	of	ADP
dti-1416	27	34	drug	drug	NOUN
dti-1416	27	35	therapy	therapy	NOUN
dti-1416	27	36	.	.	PUNCT
dti-1416	28	1	keywords	keyword	NOUN
dti-1416	28	2	:	:	PUNCT
dti-1416	28	3	pharmacogenomics	pharmacogenomic	NOUN
dti-1416	28	4	,	,	PUNCT
dti-1416	28	5	pharmacogenetics	pharmacogenetic	NOUN
dti-1416	28	6	,	,	PUNCT
dti-1416	28	7	personalized	personalized	ADJ
dti-1416	28	8	medicine	medicine	NOUN
dti-1416	28	9	,	,	PUNCT
dti-1416	28	10	pharmacogenomics	pharmacogenomic	NOUN
dti-1416	28	11	knowledge	knowledge	PROPN
dti-1416	28	12	base	base	PROPN
dti-1416	28	13	received	receive	VERB
dti-1416	28	14	:	:	PUNCT
dti-1416	28	15	september	september	PROPN
dti-1416	28	16	25	25	NUM
dti-1416	28	17	,	,	PUNCT
dti-1416	28	18	2019	2019	NUM
dti-1416	28	19	.	.	PUNCT
dti-1416	29	1	accepted	accept	VERB
dti-1416	29	2	:	:	PUNCT
dti-1416	29	3	october	october	PROPN
dti-1416	29	4	7	7	NUM
dti-1416	29	5	,	,	PUNCT
dti-1416	29	6	2019	2019	NUM
dti-1416	29	7	.	.	PUNCT
dti-1416	30	1	type	type	NOUN
dti-1416	30	2	:	:	PUNCT
dti-1416	30	3	review	review	NOUN
dti-1416	30	4	funding	funding	NOUN
dti-1416	30	5	:	:	PUNCT
dti-1416	30	6	the	the	DET
dti-1416	30	7	author(s	author(s	PROPN
dti-1416	30	8	)	)	PUNCT
dti-1416	30	9	received	receive	VERB
dti-1416	30	10	no	no	DET
dti-1416	30	11	financial	financial	ADJ
dti-1416	30	12	support	support	NOUN
dti-1416	30	13	for	for	ADP
dti-1416	30	14	the	the	DET
dti-1416	30	15	research	research	NOUN
dti-1416	30	16	,	,	PUNCT
dti-1416	30	17	authorship	authorship	NOUN
dti-1416	30	18	,	,	PUNCT
dti-1416	30	19	and/or	and/or	CCONJ
dti-1416	30	20	publication	publication	NOUN
dti-1416	30	21	of	of	ADP
dti-1416	30	22	this	this	DET
dti-1416	30	23	article	article	NOUN
dti-1416	30	24	.	.	PUNCT
dti-1416	31	1	declaration	declaration	NOUN
dti-1416	31	2	of	of	ADP
dti-1416	31	3	conflicting	conflicting	ADJ
dti-1416	31	4	interests	interest	NOUN
dti-1416	31	5	:	:	PUNCT
dti-1416	31	6	the	the	DET
dti-1416	31	7	author(s	author(s	NOUN
dti-1416	31	8	)	)	PUNCT
dti-1416	31	9	declared	declare	VERB
dti-1416	31	10	no	no	DET
dti-1416	31	11	potential	potential	ADJ
dti-1416	31	12	conflicts	conflict	NOUN
dti-1416	31	13	of	of	ADP
dti-1416	31	14	interest	interest	NOUN
dti-1416	31	15	with	with	ADP
dti-1416	31	16	respect	respect	NOUN
dti-1416	31	17	to	to	ADP
dti-1416	31	18	the	the	DET
dti-1416	31	19	research	research	NOUN
dti-1416	31	20	,	,	PUNCT
dti-1416	31	21	authorship	authorship	NOUN
dti-1416	31	22	,	,	PUNCT
dti-1416	31	23	and/or	and/or	CCONJ
dti-1416	31	24	publication	publication	NOUN
dti-1416	31	25	of	of	ADP
dti-1416	31	26	this	this	DET
dti-1416	31	27	article	article	NOUN
dti-1416	31	28	.	.	PUNCT
dti-1416	32	1	corresponding	correspond	VERB
dti-1416	32	2	author	author	NOUN
dti-1416	32	3	:	:	PUNCT
dti-1416	32	4	kathleen	kathleen	PROPN
dti-1416	32	5	b	b	PROPN
dti-1416	32	6	orrico	orrico	PROPN
dti-1416	32	7	,	,	PUNCT
dti-1416	32	8	university	university	PROPN
dti-1416	32	9	of	of	ADP
dti-1416	32	10	california	california	PROPN
dti-1416	32	11	san	san	PROPN
dti-1416	32	12	francisco	francisco	PROPN
dti-1416	32	13	,	,	PUNCT
dti-1416	32	14	school	school	NOUN
dti-1416	32	15	of	of	ADP
dti-1416	32	16	pharmacy	pharmacy	NOUN
dti-1416	32	17	,	,	PUNCT
dti-1416	32	18	1430	1430	NUM
dti-1416	32	19	rosemary	rosemary	ADJ
dti-1416	32	20	street	street	NOUN
dti-1416	32	21	,	,	PUNCT
dti-1416	32	22	menlo	menlo	NOUN
dti-1416	32	23	park	park	NOUN
dti-1416	32	24	,	,	PUNCT
dti-1416	32	25	ca	ca	PROPN
dti-1416	32	26	94025	94025	NUM
dti-1416	32	27	,	,	PUNCT
dti-1416	32	28	usa	usa	PROPN
dti-1416	32	29	.	.	PROPN
dti-1416	32	30	emails	email	NOUN
dti-1416	32	31	:	:	PUNCT
dti-1416	32	32	kathleen.orrico@ucsf.edu	kathleen.orrico@ucsf.edu	NOUN
dti-1416	32	33	;	;	PUNCT
dti-1416	32	34	orricok@comcast.net	orricok@comcast.net	PROPN
dti-1416	32	35	886875	886875	NUM
dti-1416	32	36	dti0010.1177/1177392819886875drug	dti0010.1177/1177392819886875drug	PROPN
dti-1416	32	37	target	target	NOUN
dti-1416	32	38	insightsorrico	insightsorrico	NOUN
dti-1416	32	39	review	review	NOUN
dti-1416	32	40	-	-	PUNCT
dti-1416	32	41	article2019	article2019	PROPN
dti-1416	32	42	www.genome.gov	www.genome.gov	ADJ
dti-1416	32	43	mailto:kathleen.orrico@ucsf.edu	mailto:kathleen.orrico@ucsf.edu	VERB
dti-1416	32	44	mailto:orricok@comcast.net	mailto:orricok@comcast.net	NOUN
dti-1416	32	45	2	2	NUM
dti-1416	32	46	drug	drug	NOUN
dti-1416	32	47	target	target	NOUN
dti-1416	32	48	insights	insight	NOUN
dti-1416	32	49	proteins	protein	NOUN
dti-1416	32	50	are	be	AUX
dti-1416	32	51	unique	unique	ADJ
dti-1416	32	52	molecules	molecule	NOUN
dti-1416	32	53	in	in	SCONJ
dti-1416	32	54	that	that	SCONJ
dti-1416	32	55	their	their	PRON
dti-1416	32	56	function	function	NOUN
dti-1416	32	57	is	be	AUX
dti-1416	32	58	greatly	greatly	ADV
dti-1416	32	59	affected	affect	VERB
dti-1416	32	60	by	by	ADP
dti-1416	32	61	their	their	PRON
dti-1416	32	62	conformational	conformational	ADJ
dti-1416	32	63	shape	shape	NOUN
dti-1416	32	64	.	.	PUNCT
dti-1416	33	1	variation	variation	NOUN
dti-1416	33	2	in	in	ADP
dti-1416	33	3	the	the	DET
dti-1416	33	4	amino	amino	NOUN
dti-1416	33	5	acid	acid	NOUN
dti-1416	33	6	composition	composition	NOUN
dti-1416	33	7	of	of	ADP
dti-1416	33	8	a	a	DET
dti-1416	33	9	protein	protein	NOUN
dti-1416	33	10	,	,	PUNCT
dti-1416	33	11	which	which	PRON
dti-1416	33	12	is	be	AUX
dti-1416	33	13	translated	translate	VERB
dti-1416	33	14	from	from	ADP
dti-1416	33	15	a	a	DET
dti-1416	33	16	gene(s	gene(s	NOUN
dti-1416	33	17	)	)	PUNCT
dti-1416	33	18	,	,	PUNCT
dti-1416	33	19	can	can	AUX
dti-1416	33	20	influence	influence	VERB
dti-1416	33	21	molecular	molecular	ADJ
dti-1416	33	22	folding	folding	NOUN
dti-1416	33	23	,	,	PUNCT
dti-1416	33	24	and	and	CCONJ
dti-1416	33	25	therefore	therefore	ADV
dti-1416	33	26	the	the	DET
dti-1416	33	27	biological	biological	ADJ
dti-1416	33	28	activity	activity	NOUN
dti-1416	33	29	of	of	ADP
dti-1416	33	30	the	the	DET
dti-1416	33	31	polypeptide	polypeptide	ADJ
dti-1416	33	32	molecule	molecule	NOUN
dti-1416	33	33	produced	produce	VERB
dti-1416	33	34	.	.	PUNCT
dti-1416	34	1	for	for	ADP
dti-1416	34	2	example	example	NOUN
dti-1416	34	3	,	,	PUNCT
dti-1416	34	4	the	the	DET
dti-1416	34	5	cftr	cftr	NOUN
dti-1416	34	6	gene	gene	NOUN
dti-1416	34	7	“	"	PUNCT
dti-1416	34	8	encodes	encodes	PROPN
dti-1416	34	9	”	"	PUNCT
dti-1416	34	10	for	for	ADP
dti-1416	34	11	a	a	DET
dti-1416	34	12	protein	protein	NOUN
dti-1416	34	13	structure	structure	NOUN
dti-1416	34	14	called	call	VERB
dti-1416	34	15	the	the	DET
dti-1416	34	16	cystic	cystic	ADJ
dti-1416	34	17	fibrosis	fibrosis	NOUN
dti-1416	34	18	transmembrane	transmembrane	NOUN
dti-1416	34	19	conductance	conductance	NOUN
dti-1416	34	20	regulator	regulator	NOUN
dti-1416	34	21	(	(	PUNCT
dti-1416	34	22	cftr	cftr	PROPN
dti-1416	34	23	)	)	PUNCT
dti-1416	34	24	,	,	PUNCT
dti-1416	34	25	which	which	PRON
dti-1416	34	26	serves	serve	VERB
dti-1416	34	27	as	as	ADP
dti-1416	34	28	a	a	DET
dti-1416	34	29	channel	channel	NOUN
dti-1416	34	30	for	for	ADP
dti-1416	34	31	chloride	chloride	NOUN
dti-1416	34	32	ions	ion	NOUN
dti-1416	34	33	across	across	ADP
dti-1416	34	34	exocrine	exocrine	NOUN
dti-1416	34	35	cell	cell	NOUN
dti-1416	34	36	membranes	membrane	NOUN
dti-1416	34	37	mainly	mainly	ADV
dti-1416	34	38	in	in	ADP
dti-1416	34	39	lung	lung	NOUN
dti-1416	34	40	and	and	CCONJ
dti-1416	34	41	pancreatic	pancreatic	ADJ
dti-1416	34	42	duct	duct	NOUN
dti-1416	34	43	epithelium	epithelium	NOUN
dti-1416	34	44	.	.	PUNCT
dti-1416	35	1	cystic	cystic	ADJ
dti-1416	35	2	fibrosis	fibrosis	NOUN
dti-1416	35	3	is	be	AUX
dti-1416	35	4	caused	cause	VERB
dti-1416	35	5	by	by	ADP
dti-1416	35	6	variations	variation	NOUN
dti-1416	35	7	or	or	CCONJ
dti-1416	35	8	mutations	mutation	NOUN
dti-1416	35	9	in	in	ADP
dti-1416	35	10	the	the	DET
dti-1416	35	11	cftr	cftr	NOUN
dti-1416	35	12	gene	gene	NOUN
dti-1416	35	13	,	,	PUNCT
dti-1416	35	14	which	which	PRON
dti-1416	35	15	result	result	VERB
dti-1416	35	16	in	in	ADP
dti-1416	35	17	cftr	cftr	NOUN
dti-1416	35	18	proteins	protein	NOUN
dti-1416	35	19	that	that	PRON
dti-1416	35	20	differ	differ	VERB
dti-1416	35	21	in	in	ADP
dti-1416	35	22	structure	structure	NOUN
dti-1416	35	23	and	and	CCONJ
dti-1416	35	24	possess	possess	NOUN
dti-1416	35	25	limited	limit	VERB
dti-1416	35	26	to	to	ADP
dti-1416	35	27	no	no	DET
dti-1416	35	28	ability	ability	NOUN
dti-1416	35	29	to	to	PART
dti-1416	35	30	transport	transport	VERB
dti-1416	35	31	chloride	chloride	NOUN
dti-1416	35	32	and	and	CCONJ
dti-1416	35	33	other	other	ADJ
dti-1416	35	34	ions	ion	NOUN
dti-1416	35	35	.	.	PUNCT
dti-1416	36	1	this	this	PRON
dti-1416	36	2	changes	change	VERB
dti-1416	36	3	the	the	DET
dti-1416	36	4	electrolyte	electrolyte	NOUN
dti-1416	36	5	composition	composition	NOUN
dti-1416	36	6	and	and	CCONJ
dti-1416	36	7	viscosity	viscosity	NOUN
dti-1416	36	8	of	of	ADP
dti-1416	36	9	exocrine	exocrine	NOUN
dti-1416	36	10	secretions	secretion	NOUN
dti-1416	36	11	leading	lead	VERB
dti-1416	36	12	to	to	ADP
dti-1416	36	13	cystic	cystic	ADJ
dti-1416	36	14	fibrosis	fibrosis	NOUN
dti-1416	36	15	disease	disease	NOUN
dti-1416	36	16	sequelae	sequelae	PROPN
dti-1416	36	17	.	.	PUNCT
dti-1416	37	1	the	the	DET
dti-1416	37	2	most	most	ADV
dti-1416	37	3	common	common	ADJ
dti-1416	37	4	cftr	cftr	NOUN
dti-1416	37	5	gene	gene	NOUN
dti-1416	37	6	variation	variation	NOUN
dti-1416	37	7	is	be	AUX
dti-1416	37	8	caused	cause	VERB
dti-1416	37	9	by	by	ADP
dti-1416	37	10	the	the	DET
dti-1416	37	11	deletion	deletion	NOUN
dti-1416	37	12	of	of	ADP
dti-1416	37	13	1	1	NUM
dti-1416	37	14	phenylalanine	phenylalanine	NOUN
dti-1416	37	15	amino	amino	NOUN
dti-1416	37	16	acid	acid	NOUN
dti-1416	37	17	in	in	ADP
dti-1416	37	18	the	the	DET
dti-1416	37	19	cftr	cftr	NOUN
dti-1416	37	20	protein	protein	NOUN
dti-1416	37	21	produced	produce	VERB
dti-1416	37	22	.	.	PUNCT
dti-1416	38	1	this	this	DET
dti-1416	38	2	singular	singular	ADJ
dti-1416	38	3	change	change	NOUN
dti-1416	38	4	in	in	ADP
dti-1416	38	5	cftr	cftr	NOUN
dti-1416	38	6	structure	structure	NOUN
dti-1416	38	7	allows	allow	VERB
dti-1416	38	8	it	it	PRON
dti-1416	38	9	to	to	PART
dti-1416	38	10	be	be	AUX
dti-1416	38	11	sequestered	sequester	VERB
dti-1416	38	12	and	and	CCONJ
dti-1416	38	13	destroyed	destroy	VERB
dti-1416	38	14	by	by	ADP
dti-1416	38	15	regulatory	regulatory	ADJ
dti-1416	38	16	factors	factor	NOUN
dti-1416	38	17	before	before	SCONJ
dti-1416	38	18	it	it	PRON
dti-1416	38	19	can	can	AUX
dti-1416	38	20	be	be	AUX
dti-1416	38	21	placed	place	VERB
dti-1416	38	22	within	within	ADP
dti-1416	38	23	the	the	DET
dti-1416	38	24	cell	cell	NOUN
dti-1416	38	25	membrane	membrane	NOUN
dti-1416	38	26	.	.	PUNCT
dti-1416	39	1	the	the	DET
dti-1416	39	2	genome	genome	NOUN
dti-1416	39	3	or	or	CCONJ
dti-1416	39	4	complete	complete	ADJ
dti-1416	39	5	set	set	NOUN
dti-1416	39	6	of	of	ADP
dti-1416	39	7	genetic	genetic	ADJ
dti-1416	39	8	instructions	instruction	NOUN
dti-1416	39	9	for	for	ADP
dti-1416	39	10	all	all	DET
dti-1416	39	11	cellular	cellular	ADJ
dti-1416	39	12	organisms	organism	NOUN
dti-1416	39	13	such	such	ADJ
dti-1416	39	14	as	as	ADP
dti-1416	39	15	plants	plant	NOUN
dti-1416	39	16	,	,	PUNCT
dti-1416	39	17	animals	animal	NOUN
dti-1416	39	18	,	,	PUNCT
dti-1416	39	19	and	and	CCONJ
dti-1416	39	20	human	human	ADJ
dti-1416	39	21	beings	being	NOUN
dti-1416	39	22	is	be	AUX
dti-1416	39	23	spelled	spell	VERB
dti-1416	39	24	out	out	ADP
dti-1416	39	25	in	in	ADP
dti-1416	39	26	the	the	DET
dti-1416	39	27	structure	structure	NOUN
dti-1416	39	28	of	of	ADP
dti-1416	39	29	dna	dna	PROPN
dti-1416	39	30	and	and	CCONJ
dti-1416	39	31	serves	serve	VERB
dti-1416	39	32	as	as	ADP
dti-1416	39	33	the	the	DET
dti-1416	39	34	molecular	molecular	ADJ
dti-1416	39	35	basis	basis	NOUN
dti-1416	39	36	of	of	ADP
dti-1416	39	37	inheritance.5	inheritance.5	NOUN
dti-1416	39	38	the	the	DET
dti-1416	39	39	dna	dna	PROPN
dti-1416	39	40	molecule	molecule	NOUN
dti-1416	39	41	is	be	AUX
dti-1416	39	42	a	a	DET
dti-1416	39	43	large	large	ADJ
dti-1416	39	44	doublestranded	doublestranded	ADJ
dti-1416	39	45	polymer	polymer	NOUN
dti-1416	39	46	of	of	ADP
dti-1416	39	47	nucleotide	nucleotide	ADJ
dti-1416	39	48	base	base	NOUN
dti-1416	39	49	units	unit	NOUN
dti-1416	39	50	that	that	PRON
dti-1416	39	51	resembles	resemble	VERB
dti-1416	39	52	a	a	DET
dti-1416	39	53	twisted	twisted	ADJ
dti-1416	39	54	ladder	ladder	NOUN
dti-1416	39	55	and	and	CCONJ
dti-1416	39	56	is	be	AUX
dti-1416	39	57	often	often	ADV
dti-1416	39	58	referred	refer	VERB
dti-1416	39	59	to	to	ADP
dti-1416	39	60	as	as	ADP
dti-1416	39	61	a	a	DET
dti-1416	39	62	double	double	ADJ
dti-1416	39	63	helix	helix	NOUN
dti-1416	39	64	(	(	PUNCT
dti-1416	39	65	figure	figure	NOUN
dti-1416	39	66	1	1	NUM
dti-1416	39	67	)	)	PUNCT
dti-1416	39	68	.	.	PUNCT
dti-1416	40	1	the	the	DET
dti-1416	40	2	side	side	NOUN
dti-1416	40	3	rails	rail	NOUN
dti-1416	40	4	or	or	CCONJ
dti-1416	40	5	backbone	backbone	NOUN
dti-1416	40	6	of	of	ADP
dti-1416	40	7	the	the	DET
dti-1416	40	8	ladder	ladder	NOUN
dti-1416	40	9	are	be	AUX
dti-1416	40	10	composed	compose	VERB
dti-1416	40	11	of	of	ADP
dti-1416	40	12	repeating	repeat	VERB
dti-1416	40	13	units	unit	NOUN
dti-1416	40	14	of	of	ADP
dti-1416	40	15	the	the	DET
dti-1416	40	16	5	5	NUM
dti-1416	40	17	-	-	PUNCT
dti-1416	40	18	carbon	carbon	NOUN
dti-1416	40	19	sugar	sugar	NOUN
dti-1416	40	20	deoxyribose	deoxyribose	NOUN
dti-1416	40	21	linked	link	VERB
dti-1416	40	22	by	by	ADP
dti-1416	40	23	an	an	DET
dti-1416	40	24	acidic	acidic	ADJ
dti-1416	40	25	phosphate	phosphate	NOUN
dti-1416	40	26	group	group	NOUN
dti-1416	40	27	.	.	PUNCT
dti-1416	41	1	the	the	DET
dti-1416	41	2	rungs	rung	NOUN
dti-1416	41	3	of	of	ADP
dti-1416	41	4	the	the	DET
dti-1416	41	5	ladder	ladder	NOUN
dti-1416	41	6	are	be	AUX
dti-1416	41	7	formed	form	VERB
dti-1416	41	8	from	from	ADP
dti-1416	41	9	the	the	DET
dti-1416	41	10	hydrogen	hydrogen	NOUN
dti-1416	41	11	bonding	bonding	NOUN
dti-1416	41	12	of	of	ADP
dti-1416	41	13	2	2	NUM
dti-1416	41	14	of	of	ADP
dti-1416	41	15	4	4	NUM
dti-1416	41	16	different	different	ADJ
dti-1416	41	17	nitrogenous	nitrogenous	ADJ
dti-1416	41	18	bases	basis	NOUN
dti-1416	41	19	and	and	CCONJ
dti-1416	41	20	serve	serve	VERB
dti-1416	41	21	as	as	ADP
dti-1416	41	22	the	the	DET
dti-1416	41	23	connections	connection	NOUN
dti-1416	41	24	between	between	ADP
dti-1416	41	25	the	the	DET
dti-1416	41	26	2	2	NUM
dti-1416	41	27	nucleotide	nucleotide	NOUN
dti-1416	41	28	strands	strand	NOUN
dti-1416	41	29	.	.	PUNCT
dti-1416	42	1	much	much	ADV
dti-1416	42	2	as	as	SCONJ
dti-1416	42	3	binary	binary	PROPN
dti-1416	42	4	code	code	NOUN
dti-1416	42	5	is	be	AUX
dti-1416	42	6	to	to	PART
dti-1416	42	7	computer	computer	NOUN
dti-1416	42	8	language	language	NOUN
dti-1416	42	9	where	where	SCONJ
dti-1416	42	10	every	every	DET
dti-1416	42	11	instruction	instruction	NOUN
dti-1416	42	12	is	be	AUX
dti-1416	42	13	written	write	VERB
dti-1416	42	14	as	as	ADP
dti-1416	42	15	a	a	DET
dti-1416	42	16	series	series	NOUN
dti-1416	42	17	of	of	ADP
dti-1416	42	18	0s	0s	NUM
dti-1416	42	19	and	and	CCONJ
dti-1416	42	20	1s	1s	NUM
dti-1416	42	21	,	,	PUNCT
dti-1416	42	22	it	it	PRON
dti-1416	42	23	is	be	AUX
dti-1416	42	24	the	the	DET
dti-1416	42	25	sequence	sequence	NOUN
dti-1416	42	26	or	or	CCONJ
dti-1416	42	27	pattern	pattern	NOUN
dti-1416	42	28	of	of	ADP
dti-1416	42	29	these	these	DET
dti-1416	42	30	4	4	NUM
dti-1416	42	31	nitrogenous	nitrogenous	ADJ
dti-1416	42	32	bases	basis	NOUN
dti-1416	42	33	that	that	PRON
dti-1416	42	34	ultimately	ultimately	ADV
dti-1416	42	35	spells	spell	VERB
dti-1416	42	36	out	out	ADP
dti-1416	42	37	the	the	DET
dti-1416	42	38	directions	direction	NOUN
dti-1416	42	39	to	to	PART
dti-1416	42	40	make	make	VERB
dti-1416	42	41	every	every	DET
dti-1416	42	42	protein	protein	NOUN
dti-1416	42	43	.	.	PUNCT
dti-1416	43	1	the	the	DET
dti-1416	43	2	4	4	NUM
dti-1416	43	3	bases	basis	NOUN
dti-1416	43	4	in	in	ADP
dti-1416	43	5	dna	dna	PROPN
dti-1416	43	6	’s	’s	PART
dti-1416	43	7	alphabet	alphabet	NOUN
dti-1416	43	8	include	include	VERB
dti-1416	43	9	the	the	DET
dti-1416	43	10	double	double	ADJ
dti-1416	43	11	-	-	PUNCT
dti-1416	43	12	ring	ring	NOUN
dti-1416	43	13	purines	purine	NOUN
dti-1416	43	14	adenine	adenine	NOUN
dti-1416	43	15	(	(	PUNCT
dti-1416	43	16	a	a	X
dti-1416	43	17	)	)	PUNCT
dti-1416	43	18	and	and	CCONJ
dti-1416	43	19	guanine	guanine	NOUN
dti-1416	43	20	(	(	PUNCT
dti-1416	43	21	g	g	NOUN
dti-1416	43	22	)	)	PUNCT
dti-1416	43	23	and	and	CCONJ
dti-1416	43	24	the	the	DET
dti-1416	43	25	single	single	ADJ
dti-1416	43	26	-	-	PUNCT
dti-1416	43	27	ring	ring	NOUN
dti-1416	43	28	pyrimidines	pyrimidine	NOUN
dti-1416	43	29	cytosine	cytosine	NOUN
dti-1416	43	30	(	(	PUNCT
dti-1416	43	31	c	c	NOUN
dti-1416	43	32	)	)	PUNCT
dti-1416	43	33	and	and	CCONJ
dti-1416	43	34	thymine	thymine	PROPN
dti-1416	43	35	(	(	PUNCT
dti-1416	43	36	t	t	PROPN
dti-1416	43	37	)	)	PUNCT
dti-1416	43	38	;	;	PUNCT
dti-1416	43	39	1	1	NUM
dti-1416	43	40	purine	purine	NOUN
dti-1416	43	41	and	and	CCONJ
dti-1416	43	42	1	1	NUM
dti-1416	43	43	pyrimidine	pyrimidine	NOUN
dti-1416	43	44	form	form	NOUN
dti-1416	43	45	the	the	DET
dti-1416	43	46	connecting	connect	VERB
dti-1416	43	47	or	or	CCONJ
dti-1416	43	48	complementary	complementary	ADJ
dti-1416	43	49	base	base	NOUN
dti-1416	43	50	pairs	pair	NOUN
dti-1416	43	51	in	in	ADP
dti-1416	43	52	a	a	DET
dti-1416	43	53	very	very	ADV
dti-1416	43	54	specific	specific	ADJ
dti-1416	43	55	manner	manner	NOUN
dti-1416	43	56	.	.	PUNCT
dti-1416	44	1	adenine	adenine	NOUN
dti-1416	44	2	always	always	ADV
dti-1416	44	3	pairs	pair	NOUN
dti-1416	44	4	with	with	ADP
dti-1416	44	5	thymine	thymine	PROPN
dti-1416	44	6	(	(	PUNCT
dti-1416	44	7	at	at	ADP
dti-1416	44	8	)	)	PUNCT
dti-1416	44	9	using	use	VERB
dti-1416	44	10	2	2	NUM
dti-1416	44	11	hydrogen	hydrogen	NOUN
dti-1416	44	12	bonds	bond	NOUN
dti-1416	44	13	,	,	PUNCT
dti-1416	44	14	and	and	CCONJ
dti-1416	44	15	guanine	guanine	VERB
dti-1416	44	16	always	always	ADV
dti-1416	44	17	pairs	pair	NOUN
dti-1416	44	18	with	with	ADP
dti-1416	44	19	cytosine	cytosine	NOUN
dti-1416	44	20	(	(	PUNCT
dti-1416	44	21	gc	gc	PROPN
dti-1416	44	22	)	)	PUNCT
dti-1416	44	23	using	use	VERB
dti-1416	44	24	3	3	NUM
dti-1416	44	25	hydrogen	hydrogen	NOUN
dti-1416	44	26	bonds	bond	NOUN
dti-1416	44	27	.	.	PUNCT
dti-1416	45	1	therefore	therefore	ADV
dti-1416	45	2	,	,	PUNCT
dti-1416	45	3	it	it	PRON
dti-1416	45	4	is	be	AUX
dti-1416	45	5	only	only	ADV
dti-1416	45	6	necessary	necessary	ADJ
dti-1416	45	7	to	to	PART
dti-1416	45	8	determine	determine	VERB
dti-1416	45	9	the	the	DET
dti-1416	45	10	order	order	NOUN
dti-1416	45	11	of	of	ADP
dti-1416	45	12	bases	basis	NOUN
dti-1416	45	13	in	in	ADP
dti-1416	45	14	1	1	NUM
dti-1416	45	15	strand	strand	NOUN
dti-1416	45	16	of	of	ADP
dti-1416	45	17	the	the	DET
dti-1416	45	18	dna	dna	PROPN
dti-1416	45	19	molecule	molecule	NOUN
dti-1416	45	20	to	to	PART
dti-1416	45	21	deduce	deduce	VERB
dti-1416	45	22	the	the	DET
dti-1416	45	23	sequence	sequence	NOUN
dti-1416	45	24	of	of	ADP
dti-1416	45	25	the	the	DET
dti-1416	45	26	complementary	complementary	ADJ
dti-1416	45	27	strand	strand	NOUN
dti-1416	45	28	.	.	PUNCT
dti-1416	46	1	within	within	ADP
dti-1416	46	2	the	the	DET
dti-1416	46	3	nucleus	nucleus	NOUN
dti-1416	46	4	of	of	ADP
dti-1416	46	5	every	every	DET
dti-1416	46	6	human	human	ADJ
dti-1416	46	7	cell	cell	NOUN
dti-1416	46	8	except	except	SCONJ
dti-1416	46	9	red	red	ADJ
dti-1416	46	10	blood	blood	NOUN
dti-1416	46	11	cells	cell	NOUN
dti-1416	46	12	and	and	CCONJ
dti-1416	46	13	platelets	platelet	NOUN
dti-1416	46	14	,	,	PUNCT
dti-1416	46	15	dna	dna	PROPN
dti-1416	46	16	is	be	AUX
dti-1416	46	17	arranged	arrange	VERB
dti-1416	46	18	into	into	ADP
dti-1416	46	19	structures	structure	NOUN
dti-1416	46	20	known	know	VERB
dti-1416	46	21	as	as	ADP
dti-1416	46	22	chromosomes	chromosome	NOUN
dti-1416	46	23	.	.	PUNCT
dti-1416	47	1	a	a	DET
dti-1416	47	2	small	small	ADJ
dti-1416	47	3	amount	amount	NOUN
dti-1416	47	4	of	of	ADP
dti-1416	47	5	dna	dna	NOUN
dti-1416	47	6	,	,	PUNCT
dti-1416	47	7	inherited	inherit	VERB
dti-1416	47	8	through	through	ADP
dti-1416	47	9	the	the	DET
dti-1416	47	10	maternal	maternal	ADJ
dti-1416	47	11	line	line	NOUN
dti-1416	47	12	only	only	ADV
dti-1416	47	13	,	,	PUNCT
dti-1416	47	14	exists	exist	VERB
dti-1416	47	15	in	in	ADP
dti-1416	47	16	the	the	DET
dti-1416	47	17	mitochondria	mitochondria	NOUN
dti-1416	47	18	of	of	ADP
dti-1416	47	19	cells	cell	NOUN
dti-1416	47	20	and	and	CCONJ
dti-1416	47	21	is	be	AUX
dti-1416	47	22	known	know	VERB
dti-1416	47	23	as	as	ADP
dti-1416	47	24	mitochondrial	mitochondrial	ADJ
dti-1416	47	25	dna	dna	NOUN
dti-1416	47	26	(	(	PUNCT
dti-1416	47	27	mtdna	mtdna	NOUN
dti-1416	47	28	)	)	PUNCT
dti-1416	47	29	.	.	PUNCT
dti-1416	48	1	if	if	SCONJ
dti-1416	48	2	stretched	stretch	VERB
dti-1416	48	3	end	end	NOUN
dti-1416	48	4	to	to	PART
dti-1416	48	5	end	end	VERB
dti-1416	48	6	as	as	ADP
dti-1416	48	7	a	a	DET
dti-1416	48	8	continuous	continuous	ADJ
dti-1416	48	9	strand	strand	NOUN
dti-1416	48	10	,	,	PUNCT
dti-1416	48	11	the	the	DET
dti-1416	48	12	dna	dna	NOUN
dti-1416	48	13	contained	contain	VERB
dti-1416	48	14	in	in	ADP
dti-1416	48	15	1	1	NUM
dti-1416	48	16	cell	cell	NOUN
dti-1416	48	17	nucleus	nucleus	NOUN
dti-1416	48	18	called	call	VERB
dti-1416	48	19	nuclear	nuclear	ADJ
dti-1416	48	20	dna	dna	PROPN
dti-1416	48	21	(	(	PUNCT
dti-1416	48	22	ndna	ndna	ADJ
dti-1416	48	23	)	)	PUNCT
dti-1416	48	24	measures	measure	NOUN
dti-1416	48	25	over	over	ADP
dti-1416	48	26	6	6	NUM
dti-1416	48	27	feet	foot	NOUN
dti-1416	48	28	in	in	ADP
dti-1416	48	29	length	length	NOUN
dti-1416	48	30	and	and	CCONJ
dti-1416	48	31	contains	contain	VERB
dti-1416	48	32	all	all	PRON
dti-1416	48	33	of	of	ADP
dti-1416	48	34	the	the	DET
dti-1416	48	35	approximately	approximately	ADV
dti-1416	48	36	3	3	NUM
dti-1416	48	37	billion	billion	NUM
dti-1416	48	38	base	base	NOUN
dti-1416	48	39	pairs	pair	NOUN
dti-1416	48	40	that	that	PRON
dti-1416	48	41	make	make	VERB
dti-1416	48	42	up	up	ADP
dti-1416	48	43	the	the	DET
dti-1416	48	44	human	human	ADJ
dti-1416	48	45	genome	genome	NOUN
dti-1416	48	46	.	.	PUNCT
dti-1416	49	1	before	before	SCONJ
dti-1416	49	2	mitosis	mitosis	NOUN
dti-1416	49	3	or	or	CCONJ
dti-1416	49	4	cell	cell	NOUN
dti-1416	49	5	division	division	NOUN
dti-1416	49	6	begins	begin	VERB
dti-1416	49	7	,	,	PUNCT
dti-1416	49	8	ndna	ndna	ADV
dti-1416	49	9	tightly	tightly	ADV
dti-1416	49	10	coils	coil	NOUN
dti-1416	49	11	around	around	ADP
dti-1416	49	12	histone	histone	NOUN
dti-1416	49	13	proteins	protein	NOUN
dti-1416	49	14	to	to	PART
dti-1416	49	15	form	form	VERB
dti-1416	49	16	structures	structure	NOUN
dti-1416	49	17	called	call	VERB
dti-1416	49	18	chromosomes	chromosome	NOUN
dti-1416	49	19	.	.	PUNCT
dti-1416	50	1	much	much	ADV
dti-1416	50	2	more	more	ADJ
dti-1416	50	3	than	than	ADP
dti-1416	50	4	inert	inert	ADJ
dti-1416	50	5	spools	spool	NOUN
dti-1416	50	6	,	,	PUNCT
dti-1416	50	7	the	the	DET
dti-1416	50	8	function	function	NOUN
dti-1416	50	9	of	of	ADP
dti-1416	50	10	histone	histone	NOUN
dti-1416	50	11	proteins	protein	NOUN
dti-1416	50	12	has	have	AUX
dti-1416	50	13	only	only	ADV
dti-1416	50	14	begun	begin	VERB
dti-1416	50	15	to	to	PART
dti-1416	50	16	be	be	AUX
dti-1416	50	17	appreciated	appreciate	VERB
dti-1416	50	18	.	.	PUNCT
dti-1416	51	1	through	through	ADP
dti-1416	51	2	winding	wind	VERB
dti-1416	51	3	and	and	CCONJ
dti-1416	51	4	unwinding	unwinding	NOUN
dti-1416	51	5	of	of	ADP
dti-1416	51	6	the	the	DET
dti-1416	51	7	dna	dna	PROPN
dti-1416	51	8	strand	strand	NOUN
dti-1416	51	9	in	in	ADP
dti-1416	51	10	response	response	NOUN
dti-1416	51	11	to	to	ADP
dti-1416	51	12	intracellular	intracellular	ADJ
dti-1416	51	13	signaling	signal	VERB
dti-1416	51	14	,	,	PUNCT
dti-1416	51	15	histones	histone	NOUN
dti-1416	51	16	orchestrate	orchestrate	ADJ
dti-1416	51	17	gene	gene	NOUN
dti-1416	51	18	exposure	exposure	NOUN
dti-1416	51	19	to	to	ADP
dti-1416	51	20	the	the	DET
dti-1416	51	21	cellular	cellular	ADJ
dti-1416	51	22	environment	environment	NOUN
dti-1416	51	23	and	and	CCONJ
dti-1416	51	24	play	play	VERB
dti-1416	51	25	a	a	DET
dti-1416	51	26	role	role	NOUN
dti-1416	51	27	in	in	ADP
dti-1416	51	28	gene	gene	NOUN
dti-1416	51	29	expression	expression	NOUN
dti-1416	51	30	.	.	PUNCT
dti-1416	52	1	chromosomes	chromosome	NOUN
dti-1416	52	2	are	be	AUX
dti-1416	52	3	not	not	PART
dti-1416	52	4	static	static	ADJ
dti-1416	52	5	structures	structure	NOUN
dti-1416	52	6	but	but	CCONJ
dti-1416	52	7	rather	rather	ADV
dti-1416	52	8	active	active	ADJ
dti-1416	52	9	arrangements	arrangement	NOUN
dti-1416	52	10	of	of	ADP
dti-1416	52	11	specific	specific	ADJ
dti-1416	52	12	sections	section	NOUN
dti-1416	52	13	of	of	ADP
dti-1416	52	14	the	the	DET
dti-1416	52	15	ndna	ndna	ADJ
dti-1416	52	16	strand	strand	NOUN
dti-1416	52	17	that	that	PRON
dti-1416	52	18	comprise	comprise	VERB
dti-1416	52	19	the	the	DET
dti-1416	52	20	whole	whole	ADJ
dti-1416	52	21	genome	genome	NOUN
dti-1416	52	22	.	.	PUNCT
dti-1416	53	1	the	the	DET
dti-1416	53	2	size	size	NOUN
dti-1416	53	3	of	of	ADP
dti-1416	53	4	human	human	ADJ
dti-1416	53	5	chromosomes	chromosome	NOUN
dti-1416	53	6	ranges	range	VERB
dti-1416	53	7	from	from	ADP
dti-1416	53	8	50	50	NUM
dti-1416	53	9	000	000	NUM
dti-1416	53	10	000	000	NUM
dti-1416	53	11	to	to	ADP
dti-1416	53	12	300	300	NUM
dti-1416	53	13	000	000	NUM
dti-1416	53	14	000	000	NUM
dti-1416	53	15	base	base	NOUN
dti-1416	53	16	pairs	pair	NOUN
dti-1416	53	17	and	and	CCONJ
dti-1416	53	18	can	can	AUX
dti-1416	53	19	contain	contain	VERB
dti-1416	53	20	hundreds	hundred	NOUN
dti-1416	53	21	to	to	PART
dti-1416	53	22	thousands	thousand	NOUN
dti-1416	53	23	of	of	ADP
dti-1416	53	24	genes.6	genes.6	PROPN
dti-1416	53	25	chromosome	chromosome	NOUN
dti-1416	53	26	1	1	NUM
dti-1416	53	27	,	,	PUNCT
dti-1416	53	28	for	for	ADP
dti-1416	53	29	example	example	NOUN
dti-1416	53	30	,	,	PUNCT
dti-1416	53	31	which	which	PRON
dti-1416	53	32	is	be	AUX
dti-1416	53	33	the	the	DET
dti-1416	53	34	largest	large	ADJ
dti-1416	53	35	,	,	PUNCT
dti-1416	53	36	contains	contain	VERB
dti-1416	53	37	approximately	approximately	ADV
dti-1416	53	38	2100	2100	NUM
dti-1416	53	39	protein	protein	NOUN
dti-1416	53	40	-	-	PUNCT
dti-1416	53	41	coding	code	VERB
dti-1416	53	42	genes	gene	NOUN
dti-1416	53	43	,	,	PUNCT
dti-1416	53	44	while	while	SCONJ
dti-1416	53	45	the	the	DET
dti-1416	53	46	y	y	PROPN
dti-1416	53	47	chromosome	chromosome	NOUN
dti-1416	53	48	contains	contain	VERB
dti-1416	53	49	the	the	DET
dti-1416	53	50	least	least	ADJ
dti-1416	53	51	number	number	NOUN
dti-1416	53	52	or	or	CCONJ
dti-1416	53	53	60	60	NUM
dti-1416	53	54	functional	functional	ADJ
dti-1416	53	55	genes	gene	NOUN
dti-1416	53	56	.	.	PUNCT
dti-1416	54	1	chromosomes	chromosome	NOUN
dti-1416	54	2	are	be	AUX
dti-1416	54	3	typically	typically	ADV
dti-1416	54	4	depicted	depict	VERB
dti-1416	54	5	as	as	ADP
dti-1416	54	6	in	in	ADP
dti-1416	54	7	figure	figure	NOUN
dti-1416	54	8	2	2	NUM
dti-1416	54	9	,	,	PUNCT
dti-1416	54	10	when	when	SCONJ
dti-1416	54	11	they	they	PRON
dti-1416	54	12	are	be	AUX
dti-1416	54	13	most	most	ADV
dti-1416	54	14	visible	visible	ADJ
dti-1416	54	15	.	.	PUNCT
dti-1416	55	1	this	this	DET
dti-1416	55	2	arrangement	arrangement	NOUN
dti-1416	55	3	occurs	occur	VERB
dti-1416	55	4	immediately	immediately	ADV
dti-1416	55	5	before	before	ADP
dti-1416	55	6	cell	cell	NOUN
dti-1416	55	7	division	division	NOUN
dti-1416	55	8	and	and	CCONJ
dti-1416	55	9	after	after	ADP
dti-1416	55	10	figure	figure	NOUN
dti-1416	55	11	1	1	NUM
dti-1416	55	12	.	.	PUNCT
dti-1416	55	13	double	double	ADJ
dti-1416	55	14	helix	helix	ADJ
dti-1416	55	15	structure	structure	NOUN
dti-1416	55	16	of	of	ADP
dti-1416	55	17	deoxyribonucleic	deoxyribonucleic	ADJ
dti-1416	55	18	acid	acid	NOUN
dti-1416	55	19	(	(	PUNCT
dti-1416	55	20	dna	dna	PROPN
dti-1416	55	21	)	)	PUNCT
dti-1416	55	22	.	.	PUNCT
dti-1416	56	1	source	source	NOUN
dti-1416	56	2	:	:	PUNCT
dti-1416	56	3	genetics	genetic	NOUN
dti-1416	56	4	home	home	ADV
dti-1416	56	5	reference.5	reference.5	NOUN
dti-1416	56	6	figure	figure	NOUN
dti-1416	56	7	2	2	NUM
dti-1416	56	8	.	.	PUNCT
dti-1416	57	1	the	the	DET
dti-1416	57	2	structure	structure	NOUN
dti-1416	57	3	of	of	ADP
dti-1416	57	4	a	a	DET
dti-1416	57	5	human	human	ADJ
dti-1416	57	6	chromosome	chromosome	NOUN
dti-1416	57	7	.	.	PUNCT
dti-1416	58	1	dna	dna	PROPN
dti-1416	58	2	indicates	indicate	VERB
dti-1416	58	3	deoxyribonucleic	deoxyribonucleic	ADJ
dti-1416	58	4	acid	acid	NOUN
dti-1416	58	5	.	.	PUNCT
dti-1416	59	1	source	source	NOUN
dti-1416	59	2	:	:	PUNCT
dti-1416	59	3	genetics	genetics	PROPN
dti-1416	59	4	home	home	NOUN
dti-1416	59	5	reference.7	reference.7	NOUN
dti-1416	59	6	orrico	orrico	PROPN
dti-1416	59	7	3	3	NUM
dti-1416	59	8	the	the	DET
dti-1416	59	9	dna	dna	PROPN
dti-1416	59	10	has	have	AUX
dti-1416	59	11	been	be	AUX
dti-1416	59	12	replicated	replicate	VERB
dti-1416	59	13	forming	form	VERB
dti-1416	59	14	2	2	NUM
dti-1416	59	15	sister	sister	NOUN
dti-1416	59	16	chromatid	chromatid	ADJ
dti-1416	59	17	strands	strand	NOUN
dti-1416	59	18	held	hold	VERB
dti-1416	59	19	in	in	ADP
dti-1416	59	20	contact	contact	NOUN
dti-1416	59	21	by	by	ADP
dti-1416	59	22	a	a	DET
dti-1416	59	23	centromere	centromere	NOUN
dti-1416	59	24	.	.	PUNCT
dti-1416	60	1	within	within	ADP
dti-1416	60	2	the	the	DET
dti-1416	60	3	nucleus	nucleus	NOUN
dti-1416	60	4	of	of	ADP
dti-1416	60	5	every	every	DET
dti-1416	60	6	cell	cell	NOUN
dti-1416	60	7	,	,	PUNCT
dti-1416	60	8	except	except	SCONJ
dti-1416	60	9	sperm	sperm	NOUN
dti-1416	60	10	and	and	CCONJ
dti-1416	60	11	egg	egg	NOUN
dti-1416	60	12	cells	cell	NOUN
dti-1416	60	13	,	,	PUNCT
dti-1416	60	14	humans	human	NOUN
dti-1416	60	15	have	have	VERB
dti-1416	60	16	a	a	DET
dti-1416	60	17	total	total	NOUN
dti-1416	60	18	of	of	ADP
dti-1416	60	19	46	46	NUM
dti-1416	60	20	chromosomes	chromosome	NOUN
dti-1416	60	21	existing	exist	VERB
dti-1416	60	22	as	as	ADP
dti-1416	60	23	23	23	NUM
dti-1416	60	24	pairs	pair	NOUN
dti-1416	60	25	composed	compose	VERB
dti-1416	60	26	of	of	ADP
dti-1416	60	27	1	1	NUM
dti-1416	60	28	chromosome	chromosome	NOUN
dti-1416	60	29	contributed	contribute	VERB
dti-1416	60	30	from	from	ADP
dti-1416	60	31	the	the	DET
dti-1416	60	32	mother	mother	NOUN
dti-1416	60	33	and	and	CCONJ
dti-1416	60	34	1	1	NUM
dti-1416	60	35	from	from	ADP
dti-1416	60	36	the	the	DET
dti-1416	60	37	father	father	NOUN
dti-1416	60	38	;	;	PUNCT
dti-1416	60	39	22	22	NUM
dti-1416	60	40	of	of	ADP
dti-1416	60	41	these	these	DET
dti-1416	60	42	pairs	pair	NOUN
dti-1416	60	43	are	be	AUX
dti-1416	60	44	called	call	VERB
dti-1416	60	45	autosomes	autosome	NOUN
dti-1416	60	46	and	and	CCONJ
dti-1416	60	47	are	be	AUX
dti-1416	60	48	identified	identify	VERB
dti-1416	60	49	by	by	ADP
dti-1416	60	50	number	number	NOUN
dti-1416	60	51	from	from	ADP
dti-1416	60	52	the	the	DET
dti-1416	60	53	largest	large	ADJ
dti-1416	60	54	in	in	ADP
dti-1416	60	55	size	size	NOUN
dti-1416	60	56	(	(	PUNCT
dti-1416	60	57	chromosome	chromosome	NOUN
dti-1416	60	58	1	1	NUM
dti-1416	60	59	)	)	PUNCT
dti-1416	60	60	to	to	ADP
dti-1416	60	61	the	the	DET
dti-1416	60	62	smallest	small	ADJ
dti-1416	60	63	(	(	PUNCT
dti-1416	60	64	chromosomes	chromosome	NOUN
dti-1416	60	65	22	22	NUM
dti-1416	60	66	)	)	PUNCT
dti-1416	60	67	.	.	PUNCT
dti-1416	61	1	the	the	DET
dti-1416	61	2	23rd	23rd	ADJ
dti-1416	61	3	or	or	CCONJ
dti-1416	61	4	last	last	ADJ
dti-1416	61	5	pair	pair	NOUN
dti-1416	61	6	are	be	AUX
dti-1416	61	7	the	the	DET
dti-1416	61	8	non	non	ADJ
dti-1416	61	9	-	-	ADJ
dti-1416	61	10	identical	identical	ADJ
dti-1416	61	11	sex	sex	NOUN
dti-1416	61	12	chromosomes	chromosome	NOUN
dti-1416	61	13	.	.	PUNCT
dti-1416	62	1	named	name	VERB
dti-1416	62	2	the	the	DET
dti-1416	62	3	x	x	PROPN
dti-1416	62	4	and	and	CCONJ
dti-1416	62	5	y	y	PROPN
dti-1416	62	6	chromosomes	chromosome	NOUN
dti-1416	62	7	,	,	PUNCT
dti-1416	62	8	they	they	PRON
dti-1416	62	9	determine	determine	VERB
dti-1416	62	10	the	the	DET
dti-1416	62	11	sex	sex	NOUN
dti-1416	62	12	of	of	ADP
dti-1416	62	13	the	the	DET
dti-1416	62	14	offspring	offspring	NOUN
dti-1416	62	15	.	.	PUNCT
dti-1416	63	1	at	at	ADP
dti-1416	63	2	the	the	DET
dti-1416	63	3	ends	end	NOUN
dti-1416	63	4	or	or	CCONJ
dti-1416	63	5	tips	tip	NOUN
dti-1416	63	6	of	of	ADP
dti-1416	63	7	the	the	DET
dti-1416	63	8	dna	dna	PROPN
dti-1416	63	9	strands	strand	NOUN
dti-1416	63	10	that	that	PRON
dti-1416	63	11	form	form	NOUN
dti-1416	63	12	chromosomes	chromosome	NOUN
dti-1416	63	13	are	be	AUX
dti-1416	63	14	repeating	repeat	VERB
dti-1416	63	15	sequences	sequence	NOUN
dti-1416	63	16	of	of	ADP
dti-1416	63	17	base	base	NOUN
dti-1416	63	18	pairs	pair	NOUN
dti-1416	63	19	called	call	VERB
dti-1416	63	20	telomeres.8	telomeres.8	PROPN
dti-1416	63	21	rather	rather	ADV
dti-1416	63	22	like	like	ADP
dti-1416	63	23	caps	cap	NOUN
dti-1416	63	24	or	or	CCONJ
dti-1416	63	25	aglets	aglet	NOUN
dti-1416	63	26	at	at	ADP
dti-1416	63	27	the	the	DET
dti-1416	63	28	end	end	NOUN
dti-1416	63	29	of	of	ADP
dti-1416	63	30	shoelaces	shoelace	NOUN
dti-1416	63	31	,	,	PUNCT
dti-1416	63	32	telomeres	telomere	NOUN
dti-1416	63	33	protect	protect	VERB
dti-1416	63	34	the	the	DET
dti-1416	63	35	chromosome	chromosome	NOUN
dti-1416	63	36	from	from	ADP
dti-1416	63	37	breakdown	breakdown	NOUN
dti-1416	63	38	by	by	ADP
dti-1416	63	39	providing	provide	VERB
dti-1416	63	40	spare	spare	ADJ
dti-1416	63	41	parts	part	NOUN
dti-1416	63	42	for	for	ADP
dti-1416	63	43	the	the	DET
dti-1416	63	44	ongoing	ongoing	ADJ
dti-1416	63	45	process	process	NOUN
dti-1416	63	46	of	of	ADP
dti-1416	63	47	dna	dna	PROPN
dti-1416	63	48	repair	repair	NOUN
dti-1416	63	49	that	that	PRON
dti-1416	63	50	occurs	occur	VERB
dti-1416	63	51	during	during	ADP
dti-1416	63	52	replication	replication	NOUN
dti-1416	63	53	.	.	PUNCT
dti-1416	64	1	an	an	DET
dti-1416	64	2	association	association	NOUN
dti-1416	64	3	exists	exist	VERB
dti-1416	64	4	between	between	ADP
dti-1416	64	5	the	the	DET
dti-1416	64	6	length	length	NOUN
dti-1416	64	7	of	of	ADP
dti-1416	64	8	telomeres	telomere	NOUN
dti-1416	64	9	and	and	CCONJ
dti-1416	64	10	the	the	DET
dti-1416	64	11	life	life	NOUN
dti-1416	64	12	span	span	NOUN
dti-1416	64	13	of	of	ADP
dti-1416	64	14	a	a	DET
dti-1416	64	15	cell	cell	NOUN
dti-1416	64	16	,	,	PUNCT
dti-1416	64	17	and	and	CCONJ
dti-1416	64	18	thus	thus	ADV
dti-1416	64	19	the	the	DET
dti-1416	64	20	ultimate	ultimate	ADJ
dti-1416	64	21	age	age	NOUN
dti-1416	64	22	of	of	ADP
dti-1416	64	23	a	a	DET
dti-1416	64	24	living	live	VERB
dti-1416	64	25	organism	organism	NOUN
dti-1416	64	26	.	.	PUNCT
dti-1416	65	1	genes	gene	NOUN
dti-1416	65	2	a	a	DET
dti-1416	65	3	gene	gene	NOUN
dti-1416	65	4	is	be	AUX
dti-1416	65	5	a	a	DET
dti-1416	65	6	specific	specific	ADJ
dti-1416	65	7	section	section	NOUN
dti-1416	65	8	of	of	ADP
dti-1416	65	9	the	the	DET
dti-1416	65	10	dna	dna	PROPN
dti-1416	65	11	base	base	NOUN
dti-1416	65	12	pair	pair	NOUN
dti-1416	65	13	sequence	sequence	NOUN
dti-1416	65	14	located	locate	VERB
dti-1416	65	15	on	on	ADP
dti-1416	65	16	the	the	DET
dti-1416	65	17	chromosome	chromosome	NOUN
dti-1416	65	18	,	,	PUNCT
dti-1416	65	19	which	which	PRON
dti-1416	65	20	acts	act	VERB
dti-1416	65	21	as	as	ADP
dti-1416	65	22	a	a	DET
dti-1416	65	23	recipe	recipe	NOUN
dti-1416	65	24	or	or	CCONJ
dti-1416	65	25	code	code	NOUN
dti-1416	65	26	that	that	PRON
dti-1416	65	27	is	be	AUX
dti-1416	65	28	transcribed	transcribe	VERB
dti-1416	65	29	and	and	CCONJ
dti-1416	65	30	then	then	ADV
dti-1416	65	31	translated	translate	VERB
dti-1416	65	32	into	into	ADP
dti-1416	65	33	the	the	DET
dti-1416	65	34	amino	amino	NOUN
dti-1416	65	35	acid	acid	NOUN
dti-1416	65	36	structure	structure	NOUN
dti-1416	65	37	of	of	ADP
dti-1416	65	38	a	a	DET
dti-1416	65	39	protein	protein	NOUN
dti-1416	65	40	.	.	PUNCT
dti-1416	66	1	of	of	ADP
dti-1416	66	2	the	the	DET
dti-1416	66	3	estimated	estimate	VERB
dti-1416	66	4	20	20	NUM
dti-1416	66	5	000	000	NUM
dti-1416	66	6	protein	protein	NOUN
dti-1416	66	7	-	-	PUNCT
dti-1416	66	8	coding	code	VERB
dti-1416	66	9	genes	gene	NOUN
dti-1416	66	10	in	in	ADP
dti-1416	66	11	the	the	DET
dti-1416	66	12	human	human	ADJ
dti-1416	66	13	genome	genome	NOUN
dti-1416	66	14	,	,	PUNCT
dti-1416	66	15	each	each	PRON
dti-1416	66	16	makes	make	VERB
dti-1416	66	17	an	an	DET
dti-1416	66	18	average	average	NOUN
dti-1416	66	19	of	of	ADP
dti-1416	66	20	3	3	NUM
dti-1416	66	21	proteins.7	proteins.7	NOUN
dti-1416	66	22	the	the	DET
dti-1416	66	23	gene	gene	NOUN
dti-1416	66	24	’s	’s	PART
dti-1416	66	25	dna	dna	PROPN
dti-1416	66	26	sequence	sequence	NOUN
dti-1416	66	27	is	be	AUX
dti-1416	66	28	divided	divide	VERB
dti-1416	66	29	into	into	ADP
dti-1416	66	30	regions	region	NOUN
dti-1416	66	31	called	call	VERB
dti-1416	66	32	exons	exon	NOUN
dti-1416	66	33	and	and	CCONJ
dti-1416	66	34	introns	intron	NOUN
dti-1416	66	35	.	.	PUNCT
dti-1416	67	1	during	during	ADP
dti-1416	67	2	transcription	transcription	NOUN
dti-1416	67	3	,	,	PUNCT
dti-1416	67	4	messenger	messenger	NOUN
dti-1416	67	5	ribonucleic	ribonucleic	ADJ
dti-1416	67	6	acid	acid	PROPN
dti-1416	67	7	(	(	PUNCT
dti-1416	67	8	mrna	mrna	PROPN
dti-1416	67	9	)	)	PUNCT
dti-1416	67	10	copies	copy	NOUN
dti-1416	67	11	or	or	CCONJ
dti-1416	67	12	transcribes	transcribe	NOUN
dti-1416	67	13	the	the	DET
dti-1416	67	14	code	code	NOUN
dti-1416	67	15	,	,	PUNCT
dti-1416	67	16	and	and	CCONJ
dti-1416	67	17	delivers	deliver	VERB
dti-1416	67	18	it	it	PRON
dti-1416	67	19	to	to	ADP
dti-1416	67	20	the	the	DET
dti-1416	67	21	ribosome	ribosome	NOUN
dti-1416	67	22	for	for	ADP
dti-1416	67	23	translation	translation	NOUN
dti-1416	67	24	to	to	ADP
dti-1416	67	25	a	a	DET
dti-1416	67	26	protein	protein	NOUN
dti-1416	67	27	.	.	PUNCT
dti-1416	68	1	it	it	PRON
dti-1416	68	2	is	be	AUX
dti-1416	68	3	the	the	DET
dti-1416	68	4	exons	exon	NOUN
dti-1416	68	5	or	or	CCONJ
dti-1416	68	6	protein	protein	NOUN
dti-1416	68	7	-	-	PUNCT
dti-1416	68	8	coding	code	VERB
dti-1416	68	9	portions	portion	NOUN
dti-1416	68	10	of	of	ADP
dti-1416	68	11	the	the	DET
dti-1416	68	12	sequence	sequence	NOUN
dti-1416	68	13	that	that	PRON
dti-1416	68	14	ultimately	ultimately	ADV
dti-1416	68	15	determine	determine	VERB
dti-1416	68	16	which	which	PRON
dti-1416	68	17	amino	amino	NOUN
dti-1416	68	18	acids	acid	NOUN
dti-1416	68	19	comprise	comprise	VERB
dti-1416	68	20	a	a	DET
dti-1416	68	21	given	give	VERB
dti-1416	68	22	protein	protein	NOUN
dti-1416	68	23	.	.	PUNCT
dti-1416	69	1	the	the	DET
dti-1416	69	2	intron	intron	ADJ
dti-1416	69	3	sections	section	NOUN
dti-1416	69	4	perform	perform	VERB
dti-1416	69	5	regulatory	regulatory	ADJ
dti-1416	69	6	functions	function	NOUN
dti-1416	69	7	and	and	CCONJ
dti-1416	69	8	are	be	AUX
dti-1416	69	9	spliced	splice	VERB
dti-1416	69	10	out	out	ADP
dti-1416	69	11	.	.	PUNCT
dti-1416	70	1	the	the	DET
dti-1416	70	2	size	size	NOUN
dti-1416	70	3	of	of	ADP
dti-1416	70	4	a	a	DET
dti-1416	70	5	gene	gene	NOUN
dti-1416	70	6	is	be	AUX
dti-1416	70	7	expressed	express	VERB
dti-1416	70	8	by	by	ADP
dti-1416	70	9	the	the	DET
dti-1416	70	10	number	number	NOUN
dti-1416	70	11	of	of	ADP
dti-1416	70	12	nitrogenous	nitrogenous	ADJ
dti-1416	70	13	base	base	NOUN
dti-1416	70	14	pairs	pair	NOUN
dti-1416	70	15	it	it	PRON
dti-1416	70	16	contains	contain	VERB
dti-1416	70	17	and	and	CCONJ
dti-1416	70	18	can	can	AUX
dti-1416	70	19	range	range	VERB
dti-1416	70	20	from	from	ADP
dti-1416	70	21	a	a	DET
dti-1416	70	22	few	few	ADJ
dti-1416	70	23	hundred	hundred	NUM
dti-1416	70	24	to	to	ADP
dti-1416	70	25	over	over	ADP
dti-1416	70	26	2	2	NUM
dti-1416	70	27	million	million	NUM
dti-1416	70	28	.	.	PUNCT
dti-1416	71	1	many	many	ADJ
dti-1416	71	2	genes	gene	NOUN
dti-1416	71	3	are	be	AUX
dti-1416	71	4	named	name	VERB
dti-1416	71	5	for	for	ADP
dti-1416	71	6	the	the	DET
dti-1416	71	7	proteins	protein	NOUN
dti-1416	71	8	they	they	PRON
dti-1416	71	9	encode	encode	VERB
dti-1416	71	10	and	and	CCONJ
dti-1416	71	11	are	be	AUX
dti-1416	71	12	given	give	VERB
dti-1416	71	13	a	a	DET
dti-1416	71	14	symbol	symbol	NOUN
dti-1416	71	15	.	.	PUNCT
dti-1416	72	1	for	for	ADP
dti-1416	72	2	example	example	NOUN
dti-1416	72	3	,	,	PUNCT
dti-1416	72	4	the	the	DET
dti-1416	72	5	cytochrome	cytochrome	NOUN
dti-1416	72	6	p450	p450	PROPN
dti-1416	72	7	(	(	PUNCT
dti-1416	72	8	cyp	cyp	ADJ
dti-1416	72	9	)	)	PUNCT
dti-1416	72	10	2d6	2d6	NUM
dti-1416	72	11	enzyme	enzyme	NOUN
dti-1416	72	12	and	and	CCONJ
dti-1416	72	13	gene	gene	NOUN
dti-1416	72	14	share	share	VERB
dti-1416	72	15	the	the	DET
dti-1416	72	16	same	same	ADJ
dti-1416	72	17	name	name	NOUN
dti-1416	72	18	,	,	PUNCT
dti-1416	72	19	and	and	CCONJ
dti-1416	72	20	the	the	DET
dti-1416	72	21	gene	gene	NOUN
dti-1416	72	22	is	be	AUX
dti-1416	72	23	assigned	assign	VERB
dti-1416	72	24	the	the	DET
dti-1416	72	25	symbol	symbol	NOUN
dti-1416	72	26	cyp2d6	cyp2d6	NOUN
dti-1416	72	27	.	.	PUNCT
dti-1416	73	1	the	the	DET
dti-1416	73	2	gene	gene	NOUN
dti-1416	73	3	symbol	symbol	NOUN
dti-1416	73	4	ace	ace	NOUN
dti-1416	73	5	designates	designate	VERB
dti-1416	73	6	the	the	DET
dti-1416	73	7	angiotensin	angiotensin	NOUN
dti-1416	73	8	i	i	PRON
dti-1416	73	9	converting	convert	VERB
dti-1416	73	10	enzyme	enzyme	NOUN
dti-1416	73	11	gene	gene	NOUN
dti-1416	73	12	.	.	PUNCT
dti-1416	74	1	the	the	DET
dti-1416	74	2	human	human	ADJ
dti-1416	74	3	genome	genome	NOUN
dti-1416	74	4	organisation	organisation	NOUN
dti-1416	74	5	(	(	PUNCT
dti-1416	74	6	hugo	hugo	PROPN
dti-1416	74	7	)	)	PUNCT
dti-1416	74	8	gene	gene	NOUN
dti-1416	74	9	nomenclature	nomenclature	NOUN
dti-1416	74	10	committee	committee	NOUN
dti-1416	74	11	(	(	PUNCT
dti-1416	74	12	genenames.org	genenames.org	X
dti-1416	74	13	)	)	PUNCT
dti-1416	74	14	establishes	establish	VERB
dti-1416	74	15	an	an	DET
dti-1416	74	16	official	official	ADJ
dti-1416	74	17	name	name	NOUN
dti-1416	74	18	and	and	CCONJ
dti-1416	74	19	symbol	symbol	NOUN
dti-1416	74	20	for	for	ADP
dti-1416	74	21	each	each	DET
dti-1416	74	22	gene	gene	NOUN
dti-1416	74	23	;	;	PUNCT
dti-1416	74	24	however	however	ADV
dti-1416	74	25	,	,	PUNCT
dti-1416	74	26	be	be	AUX
dti-1416	74	27	aware	aware	ADJ
dti-1416	74	28	that	that	SCONJ
dti-1416	74	29	genes	gene	NOUN
dti-1416	74	30	may	may	AUX
dti-1416	74	31	be	be	AUX
dti-1416	74	32	referred	refer	VERB
dti-1416	74	33	to	to	ADP
dti-1416	74	34	by	by	ADP
dti-1416	74	35	multiple	multiple	ADJ
dti-1416	74	36	names	name	NOUN
dti-1416	74	37	in	in	ADP
dti-1416	74	38	the	the	DET
dti-1416	74	39	literature.9	literature.9	NOUN
dti-1416	74	40	genes	gene	NOUN
dti-1416	74	41	are	be	AUX
dti-1416	74	42	the	the	DET
dti-1416	74	43	basic	basic	ADJ
dti-1416	74	44	units	unit	NOUN
dti-1416	74	45	for	for	ADP
dti-1416	74	46	the	the	DET
dti-1416	74	47	inheritance	inheritance	NOUN
dti-1416	74	48	of	of	ADP
dti-1416	74	49	traits	trait	NOUN
dti-1416	74	50	.	.	PUNCT
dti-1416	75	1	genes	gene	NOUN
dti-1416	75	2	that	that	PRON
dti-1416	75	3	encode	encode	VERB
dti-1416	75	4	for	for	ADP
dti-1416	75	5	proteins	protein	NOUN
dti-1416	75	6	involved	involve	VERB
dti-1416	75	7	in	in	ADP
dti-1416	75	8	drug	drug	NOUN
dti-1416	75	9	action	action	NOUN
dti-1416	75	10	,	,	PUNCT
dti-1416	75	11	toxicity	toxicity	NOUN
dti-1416	75	12	,	,	PUNCT
dti-1416	75	13	or	or	CCONJ
dti-1416	75	14	metabolism	metabolism	NOUN
dti-1416	75	15	are	be	AUX
dti-1416	75	16	often	often	ADV
dti-1416	75	17	referred	refer	VERB
dti-1416	75	18	to	to	ADP
dti-1416	75	19	as	as	ADP
dti-1416	75	20	pharmacogenes	pharmacogene	NOUN
dti-1416	75	21	.	.	PUNCT
dti-1416	76	1	the	the	DET
dti-1416	76	2	term	term	NOUN
dti-1416	76	3	phenotype	phenotype	NOUN
dti-1416	76	4	is	be	AUX
dti-1416	76	5	used	use	VERB
dti-1416	76	6	to	to	PART
dti-1416	76	7	designate	designate	VERB
dti-1416	76	8	the	the	DET
dti-1416	76	9	type	type	NOUN
dti-1416	76	10	or	or	CCONJ
dti-1416	76	11	classification	classification	NOUN
dti-1416	76	12	of	of	ADP
dti-1416	76	13	a	a	DET
dti-1416	76	14	visible	visible	ADJ
dti-1416	76	15	trait	trait	NOUN
dti-1416	76	16	or	or	CCONJ
dti-1416	76	17	characteristic	characteristic	ADJ
dti-1416	76	18	resulting	result	VERB
dti-1416	76	19	from	from	ADP
dti-1416	76	20	gene	gene	NOUN
dti-1416	76	21	expression	expression	NOUN
dti-1416	76	22	such	such	ADJ
dti-1416	76	23	as	as	ADP
dti-1416	76	24	eye	eye	NOUN
dti-1416	76	25	color	color	NOUN
dti-1416	76	26	,	,	PUNCT
dti-1416	76	27	height	height	NOUN
dti-1416	76	28	,	,	PUNCT
dti-1416	76	29	or	or	CCONJ
dti-1416	76	30	the	the	DET
dti-1416	76	31	rate	rate	NOUN
dti-1416	76	32	of	of	ADP
dti-1416	76	33	cytochrome	cytochrome	ADJ
dti-1416	76	34	p450	p450	PROPN
dti-1416	76	35	(	(	PUNCT
dti-1416	76	36	cyp	cyp	ADJ
dti-1416	76	37	p450	p450	PROPN
dti-1416	76	38	)	)	PUNCT
dti-1416	76	39	metabolism	metabolism	NOUN
dti-1416	76	40	.	.	PUNCT
dti-1416	77	1	at	at	ADP
dti-1416	77	2	the	the	DET
dti-1416	77	3	time	time	NOUN
dti-1416	77	4	of	of	ADP
dti-1416	77	5	this	this	DET
dti-1416	77	6	writing	writing	NOUN
dti-1416	77	7	,	,	PUNCT
dti-1416	77	8	66	66	NUM
dti-1416	77	9	“	"	PUNCT
dti-1416	77	10	very	very	ADV
dti-1416	77	11	important	important	ADJ
dti-1416	77	12	pharmacogenes	pharmacogene	NOUN
dti-1416	77	13	”	"	PUNCT
dti-1416	77	14	(	(	PUNCT
dti-1416	77	15	vips	vip	NOUN
dti-1416	77	16	)	)	PUNCT
dti-1416	77	17	are	be	AUX
dti-1416	77	18	listed	list	VERB
dti-1416	77	19	by	by	ADP
dti-1416	77	20	the	the	DET
dti-1416	77	21	premier	premier	ADJ
dti-1416	77	22	curators	curator	NOUN
dti-1416	77	23	of	of	ADP
dti-1416	77	24	pgx	pgx	PROPN
dti-1416	77	25	information	information	NOUN
dti-1416	77	26	the	the	DET
dti-1416	77	27	pharmacogenomic	pharmacogenomic	ADJ
dti-1416	77	28	knowledge	knowledge	NOUN
dti-1416	77	29	base	base	NOUN
dti-1416	77	30	(	(	PUNCT
dti-1416	77	31	pharmgkb).10	pharmgkb).10	PROPN
dti-1416	77	32	chief	chief	NOUN
dti-1416	77	33	among	among	ADP
dti-1416	77	34	these	these	PRON
dti-1416	77	35	are	be	AUX
dti-1416	77	36	genes	gene	NOUN
dti-1416	77	37	for	for	ADP
dti-1416	77	38	specific	specific	ADJ
dti-1416	77	39	cyp	cyp	ADJ
dti-1416	77	40	p450	p450	PROPN
dti-1416	77	41	enzymes	enzyme	NOUN
dti-1416	77	42	with	with	ADP
dti-1416	77	43	known	know	VERB
dti-1416	77	44	associations	association	NOUN
dti-1416	77	45	between	between	ADP
dti-1416	77	46	variation	variation	NOUN
dti-1416	77	47	in	in	ADP
dti-1416	77	48	their	their	PRON
dti-1416	77	49	genetic	genetic	ADJ
dti-1416	77	50	recipe	recipe	NOUN
dti-1416	77	51	and	and	CCONJ
dti-1416	77	52	the	the	DET
dti-1416	77	53	phenotype	phenotype	NOUN
dti-1416	77	54	or	or	CCONJ
dti-1416	77	55	degree	degree	NOUN
dti-1416	77	56	of	of	ADP
dti-1416	77	57	enzyme	enzyme	NOUN
dti-1416	77	58	activity	activity	NOUN
dti-1416	77	59	produced	produce	VERB
dti-1416	77	60	by	by	ADP
dti-1416	77	61	the	the	DET
dti-1416	77	62	resulting	result	VERB
dti-1416	77	63	protein	protein	NOUN
dti-1416	77	64	.	.	PUNCT
dti-1416	78	1	human	human	ADJ
dti-1416	78	2	beings	being	NOUN
dti-1416	78	3	are	be	AUX
dti-1416	78	4	diploid	diploid	ADJ
dti-1416	78	5	organisms	organism	NOUN
dti-1416	78	6	,	,	PUNCT
dti-1416	78	7	meaning	mean	VERB
dti-1416	78	8	we	we	PRON
dti-1416	78	9	have	have	VERB
dti-1416	78	10	2	2	NUM
dti-1416	78	11	versions	version	NOUN
dti-1416	78	12	of	of	ADP
dti-1416	78	13	every	every	DET
dti-1416	78	14	gene	gene	NOUN
dti-1416	78	15	,	,	PUNCT
dti-1416	78	16	1	1	NUM
dti-1416	78	17	inherited	inherit	VERB
dti-1416	78	18	from	from	ADP
dti-1416	78	19	each	each	DET
dti-1416	78	20	parent	parent	NOUN
dti-1416	78	21	.	.	PUNCT
dti-1416	79	1	the	the	DET
dti-1416	79	2	process	process	NOUN
dti-1416	79	3	of	of	ADP
dti-1416	79	4	meiosis	meiosis	NOUN
dti-1416	79	5	determines	determine	NOUN
dti-1416	79	6	which	which	PRON
dti-1416	79	7	1	1	NUM
dti-1416	79	8	of	of	ADP
dti-1416	79	9	the	the	DET
dti-1416	79	10	2	2	NUM
dti-1416	79	11	genes	gene	NOUN
dti-1416	79	12	each	each	DET
dti-1416	79	13	parent	parent	NOUN
dti-1416	79	14	possesses	possesse	NOUN
dti-1416	79	15	gets	get	AUX
dti-1416	79	16	inherited	inherit	VERB
dti-1416	79	17	by	by	ADP
dti-1416	79	18	the	the	DET
dti-1416	79	19	offspring	offspring	NOUN
dti-1416	79	20	and	and	CCONJ
dti-1416	79	21	is	be	AUX
dti-1416	79	22	the	the	DET
dti-1416	79	23	basis	basis	NOUN
dti-1416	79	24	for	for	ADP
dti-1416	79	25	the	the	DET
dti-1416	79	26	mendelian	mendelian	ADJ
dti-1416	79	27	law	law	NOUN
dti-1416	79	28	of	of	ADP
dti-1416	79	29	segregation	segregation	NOUN
dti-1416	79	30	.	.	PUNCT
dti-1416	80	1	when	when	SCONJ
dti-1416	80	2	egg	egg	NOUN
dti-1416	80	3	and	and	CCONJ
dti-1416	80	4	sperm	sperm	NOUN
dti-1416	80	5	combine	combine	NOUN
dti-1416	80	6	,	,	PUNCT
dti-1416	80	7	the	the	DET
dti-1416	80	8	now	now	ADV
dti-1416	80	9	-	-	PUNCT
dti-1416	80	10	fertilized	fertilize	VERB
dti-1416	80	11	egg	egg	NOUN
dti-1416	80	12	contains	contain	VERB
dti-1416	80	13	the	the	DET
dti-1416	80	14	entire	entire	ADJ
dti-1416	80	15	genome	genome	NOUN
dti-1416	80	16	of	of	ADP
dti-1416	80	17	the	the	DET
dti-1416	80	18	offspring	offspring	NOUN
dti-1416	80	19	which	which	PRON
dti-1416	80	20	in	in	ADP
dti-1416	80	21	turn	turn	NOUN
dti-1416	80	22	gets	get	AUX
dti-1416	80	23	passed	pass	VERB
dti-1416	80	24	to	to	ADP
dti-1416	80	25	future	future	ADJ
dti-1416	80	26	cells	cell	NOUN
dti-1416	80	27	at	at	ADP
dti-1416	80	28	every	every	DET
dti-1416	80	29	cell	cell	NOUN
dti-1416	80	30	division	division	NOUN
dti-1416	80	31	.	.	PUNCT
dti-1416	81	1	the	the	DET
dti-1416	81	2	term	term	NOUN
dti-1416	81	3	genotype	genotype	NOUN
dti-1416	81	4	refers	refer	VERB
dti-1416	81	5	to	to	ADP
dti-1416	81	6	the	the	DET
dti-1416	81	7	specific	specific	ADJ
dti-1416	81	8	combination	combination	NOUN
dti-1416	81	9	of	of	ADP
dti-1416	81	10	the	the	DET
dti-1416	81	11	2	2	NUM
dti-1416	81	12	genes	gene	NOUN
dti-1416	81	13	(	(	PUNCT
dti-1416	81	14	alleles	allele	NOUN
dti-1416	81	15	)	)	PUNCT
dti-1416	81	16	an	an	DET
dti-1416	81	17	individual	individual	ADJ
dti-1416	81	18	inherits.11	inherits.11	ADJ
dti-1416	81	19	alleles	allele	NOUN
dti-1416	81	20	are	be	AUX
dti-1416	81	21	forms	form	NOUN
dti-1416	81	22	or	or	CCONJ
dti-1416	81	23	variants	variant	NOUN
dti-1416	81	24	of	of	ADP
dti-1416	81	25	the	the	DET
dti-1416	81	26	same	same	ADJ
dti-1416	81	27	gene	gene	NOUN
dti-1416	81	28	with	with	ADP
dti-1416	81	29	small	small	ADJ
dti-1416	81	30	differences	difference	NOUN
dti-1416	81	31	in	in	ADP
dti-1416	81	32	their	their	PRON
dti-1416	81	33	dna	dna	NOUN
dti-1416	81	34	base	base	NOUN
dti-1416	81	35	sequence	sequence	NOUN
dti-1416	81	36	.	.	PUNCT
dti-1416	82	1	differences	difference	NOUN
dti-1416	82	2	in	in	ADP
dti-1416	82	3	the	the	DET
dti-1416	82	4	dna	dna	PROPN
dti-1416	82	5	base	base	NOUN
dti-1416	82	6	sequence	sequence	NOUN
dti-1416	82	7	can	can	AUX
dti-1416	82	8	ultimately	ultimately	ADV
dti-1416	82	9	lead	lead	VERB
dti-1416	82	10	to	to	ADP
dti-1416	82	11	variation	variation	NOUN
dti-1416	82	12	in	in	ADP
dti-1416	82	13	the	the	DET
dti-1416	82	14	structure	structure	NOUN
dti-1416	82	15	of	of	ADP
dti-1416	82	16	the	the	DET
dti-1416	82	17	encoded	encode	VERB
dti-1416	82	18	protein	protein	NOUN
dti-1416	82	19	or	or	CCONJ
dti-1416	82	20	the	the	DET
dti-1416	82	21	amount	amount	NOUN
dti-1416	82	22	produced	produce	VERB
dti-1416	82	23	.	.	PUNCT
dti-1416	83	1	some	some	DET
dti-1416	83	2	genes	gene	NOUN
dti-1416	83	3	are	be	AUX
dti-1416	83	4	more	more	ADV
dti-1416	83	5	likely	likely	ADJ
dti-1416	83	6	than	than	SCONJ
dti-1416	83	7	others	other	NOUN
dti-1416	83	8	to	to	PART
dti-1416	83	9	be	be	AUX
dti-1416	83	10	subject	subject	ADJ
dti-1416	83	11	to	to	ADP
dti-1416	83	12	variation	variation	NOUN
dti-1416	83	13	,	,	PUNCT
dti-1416	83	14	and	and	CCONJ
dti-1416	83	15	the	the	DET
dti-1416	83	16	term	term	NOUN
dti-1416	83	17	polymorphism	polymorphism	NOUN
dti-1416	83	18	(	(	PUNCT
dti-1416	83	19	multiple	multiple	ADJ
dti-1416	83	20	forms	form	NOUN
dti-1416	83	21	)	)	PUNCT
dti-1416	83	22	is	be	AUX
dti-1416	83	23	generally	generally	ADV
dti-1416	83	24	used	use	VERB
dti-1416	83	25	to	to	PART
dti-1416	83	26	discuss	discuss	VERB
dti-1416	83	27	genes	gene	NOUN
dti-1416	83	28	with	with	ADP
dti-1416	83	29	multiple	multiple	ADJ
dti-1416	83	30	alleles	allele	NOUN
dti-1416	83	31	.	.	PUNCT
dti-1416	84	1	most	most	ADJ
dti-1416	84	2	of	of	ADP
dti-1416	84	3	the	the	DET
dti-1416	84	4	genes	gene	NOUN
dti-1416	84	5	located	locate	VERB
dti-1416	84	6	on	on	ADP
dti-1416	84	7	autosomal	autosomal	ADJ
dti-1416	84	8	chromosomes	chromosome	NOUN
dti-1416	84	9	have	have	VERB
dti-1416	84	10	biallelic	biallelic	ADJ
dti-1416	84	11	expression	expression	NOUN
dti-1416	84	12	,	,	PUNCT
dti-1416	84	13	meaning	mean	VERB
dti-1416	84	14	that	that	SCONJ
dti-1416	84	15	both	both	DET
dti-1416	84	16	copies	copy	NOUN
dti-1416	84	17	express	express	VERB
dti-1416	84	18	the	the	DET
dti-1416	84	19	encoded	encode	VERB
dti-1416	84	20	protein	protein	NOUN
dti-1416	84	21	.	.	PUNCT
dti-1416	85	1	other	other	ADJ
dti-1416	85	2	factors	factor	NOUN
dti-1416	85	3	involved	involve	VERB
dti-1416	85	4	in	in	ADP
dti-1416	85	5	gene	gene	NOUN
dti-1416	85	6	expression	expression	NOUN
dti-1416	85	7	can	can	AUX
dti-1416	85	8	influence	influence	VERB
dti-1416	85	9	when	when	SCONJ
dti-1416	85	10	or	or	CCONJ
dti-1416	85	11	whether	whether	SCONJ
dti-1416	85	12	a	a	DET
dti-1416	85	13	protein	protein	NOUN
dti-1416	85	14	will	will	AUX
dti-1416	85	15	be	be	AUX
dti-1416	85	16	made	make	VERB
dti-1416	85	17	and	and	CCONJ
dti-1416	85	18	in	in	ADP
dti-1416	85	19	what	what	DET
dti-1416	85	20	amount	amount	NOUN
dti-1416	85	21	.	.	PUNCT
dti-1416	86	1	understanding	understand	VERB
dti-1416	86	2	the	the	DET
dti-1416	86	3	implications	implication	NOUN
dti-1416	86	4	of	of	ADP
dti-1416	86	5	variation	variation	NOUN
dti-1416	86	6	in	in	ADP
dti-1416	86	7	pharmacogenes	pharmacogene	NOUN
dti-1416	86	8	is	be	AUX
dti-1416	86	9	the	the	DET
dti-1416	86	10	heart	heart	NOUN
dti-1416	86	11	and	and	CCONJ
dti-1416	86	12	soul	soul	NOUN
dti-1416	86	13	of	of	ADP
dti-1416	86	14	pgx	pgx	PROPN
dti-1416	86	15	and	and	CCONJ
dti-1416	86	16	allows	allow	VERB
dti-1416	86	17	us	we	PRON
dti-1416	86	18	to	to	PART
dti-1416	86	19	individualize	individualize	VERB
dti-1416	86	20	drug	drug	NOUN
dti-1416	86	21	therapy	therapy	NOUN
dti-1416	86	22	.	.	PUNCT
dti-1416	87	1	as	as	ADP
dti-1416	87	2	a	a	DET
dti-1416	87	3	species	specie	NOUN
dti-1416	87	4	,	,	PUNCT
dti-1416	87	5	human	human	ADJ
dti-1416	87	6	beings	being	NOUN
dti-1416	87	7	are	be	AUX
dti-1416	87	8	nearly	nearly	ADV
dti-1416	87	9	genetically	genetically	ADV
dti-1416	87	10	homogeneous	homogeneous	ADJ
dti-1416	87	11	and	and	CCONJ
dti-1416	87	12	share	share	VERB
dti-1416	87	13	over	over	ADP
dti-1416	87	14	99.9	99.9	NUM
dti-1416	87	15	%	%	NOUN
dti-1416	87	16	of	of	ADP
dti-1416	87	17	our	our	PRON
dti-1416	87	18	entire	entire	ADJ
dti-1416	87	19	genome	genome	NOUN
dti-1416	87	20	with	with	ADP
dti-1416	87	21	each	each	DET
dti-1416	87	22	other	other	ADJ
dti-1416	87	23	.	.	PUNCT
dti-1416	88	1	it	it	PRON
dti-1416	88	2	is	be	AUX
dti-1416	88	3	this	this	DET
dti-1416	88	4	less	less	ADJ
dti-1416	88	5	than	than	ADP
dti-1416	88	6	0.1	0.1	NUM
dti-1416	88	7	%	%	NOUN
dti-1416	88	8	variation	variation	NOUN
dti-1416	88	9	that	that	PRON
dti-1416	88	10	makes	make	VERB
dti-1416	88	11	each	each	PRON
dti-1416	88	12	of	of	ADP
dti-1416	88	13	us	we	PRON
dti-1416	88	14	unique	unique	ADJ
dti-1416	88	15	.	.	PUNCT
dti-1416	89	1	a	a	DET
dti-1416	89	2	set	set	NOUN
dti-1416	89	3	or	or	CCONJ
dti-1416	89	4	group	group	NOUN
dti-1416	89	5	of	of	ADP
dti-1416	89	6	gene	gene	NOUN
dti-1416	89	7	alleles	allele	NOUN
dti-1416	89	8	typically	typically	ADV
dti-1416	89	9	located	locate	VERB
dti-1416	89	10	on	on	ADP
dti-1416	89	11	the	the	DET
dti-1416	89	12	same	same	ADJ
dti-1416	89	13	chromosome	chromosome	NOUN
dti-1416	89	14	and	and	CCONJ
dti-1416	89	15	inherited	inherit	VERB
dti-1416	89	16	together	together	ADV
dti-1416	89	17	is	be	AUX
dti-1416	89	18	referred	refer	VERB
dti-1416	89	19	to	to	ADP
dti-1416	89	20	as	as	ADP
dti-1416	89	21	a	a	DET
dti-1416	89	22	haplotype	haplotype	NOUN
dti-1416	89	23	and	and	CCONJ
dti-1416	89	24	may	may	AUX
dti-1416	89	25	indicate	indicate	VERB
dti-1416	89	26	a	a	DET
dti-1416	89	27	common	common	ADJ
dti-1416	89	28	line	line	NOUN
dti-1416	89	29	of	of	ADP
dti-1416	89	30	descent	descent	NOUN
dti-1416	89	31	in	in	ADP
dti-1416	89	32	individuals	individual	NOUN
dti-1416	89	33	who	who	PRON
dti-1416	89	34	share	share	VERB
dti-1416	89	35	one	one	NUM
dti-1416	89	36	.	.	PUNCT
dti-1416	90	1	the	the	DET
dti-1416	90	2	allele	allele	NOUN
dti-1416	90	3	or	or	CCONJ
dti-1416	90	4	version	version	NOUN
dti-1416	90	5	of	of	ADP
dti-1416	90	6	a	a	DET
dti-1416	90	7	gene	gene	NOUN
dti-1416	90	8	that	that	PRON
dti-1416	90	9	produces	produce	VERB
dti-1416	90	10	a	a	DET
dti-1416	90	11	trait	trait	NOUN
dti-1416	90	12	shared	share	VERB
dti-1416	90	13	by	by	ADP
dti-1416	90	14	a	a	DET
dti-1416	90	15	sizable	sizable	ADJ
dti-1416	90	16	group	group	NOUN
dti-1416	90	17	of	of	ADP
dti-1416	90	18	individuals	individual	NOUN
dti-1416	90	19	in	in	ADP
dti-1416	90	20	a	a	DET
dti-1416	90	21	population	population	NOUN
dti-1416	90	22	is	be	AUX
dti-1416	90	23	often	often	ADV
dti-1416	90	24	referred	refer	VERB
dti-1416	90	25	to	to	ADP
dti-1416	90	26	as	as	SCONJ
dti-1416	90	27	the	the	DET
dti-1416	90	28	non	non	ADJ
dti-1416	90	29	-	-	ADJ
dti-1416	90	30	mutated	mutated	ADJ
dti-1416	90	31	or	or	CCONJ
dti-1416	90	32	wild	wild	ADJ
dti-1416	90	33	-	-	PUNCT
dti-1416	90	34	type	type	NOUN
dti-1416	90	35	allele.11	allele.11	ADP
dti-1416	90	36	the	the	DET
dti-1416	90	37	wild	wild	ADJ
dti-1416	90	38	-	-	PUNCT
dti-1416	90	39	type	type	NOUN
dti-1416	90	40	variant(s	variant(s	PROPN
dti-1416	90	41	)	)	PUNCT
dti-1416	90	42	is	be	AUX
dti-1416	90	43	often	often	ADV
dti-1416	90	44	noted	note	VERB
dti-1416	90	45	using	use	VERB
dti-1416	90	46	star	star	NOUN
dti-1416	90	47	(	(	PUNCT
dti-1416	90	48	*	*	NOUN
dti-1416	90	49	)	)	PUNCT
dti-1416	90	50	nomenclature	nomenclature	NOUN
dti-1416	90	51	and	and	CCONJ
dti-1416	90	52	written	write	VERB
dti-1416	90	53	as	as	ADP
dti-1416	90	54	the	the	DET
dti-1416	90	55	gene	gene	NOUN
dti-1416	90	56	symbol	symbol	NOUN
dti-1416	90	57	followed	follow	VERB
dti-1416	90	58	by	by	ADP
dti-1416	90	59	an	an	DET
dti-1416	90	60	asterisk	asterisk	NOUN
dti-1416	90	61	and	and	CCONJ
dti-1416	90	62	number	number	NOUN
dti-1416	90	63	1	1	NUM
dti-1416	90	64	(	(	PUNCT
dti-1416	90	65	cyp2d6	cyp2d6	NOUN
dti-1416	90	66	*	*	ADJ
dti-1416	90	67	1	1	NUM
dti-1416	90	68	)	)	PUNCT
dti-1416	90	69	.	.	PUNCT
dti-1416	91	1	it	it	PRON
dti-1416	91	2	is	be	AUX
dti-1416	91	3	possible	possible	ADJ
dti-1416	91	4	to	to	PART
dti-1416	91	5	have	have	VERB
dti-1416	91	6	more	more	ADJ
dti-1416	91	7	than	than	ADP
dti-1416	91	8	1	1	NUM
dti-1416	91	9	wild	wild	ADJ
dti-1416	91	10	-	-	PUNCT
dti-1416	91	11	type	type	NOUN
dti-1416	91	12	allele	allele	NOUN
dti-1416	91	13	typically	typically	ADV
dti-1416	91	14	noted	note	VERB
dti-1416	91	15	by	by	ADP
dti-1416	91	16	a	a	DET
dti-1416	91	17	letter	letter	NOUN
dti-1416	91	18	following	follow	VERB
dti-1416	91	19	*	*	PROPN
dti-1416	91	20	1	1	NUM
dti-1416	91	21	.	.	PUNCT
dti-1416	92	1	a	a	DET
dti-1416	92	2	person	person	NOUN
dti-1416	92	3	’s	’s	PART
dti-1416	92	4	pharmacogenes	pharmacogene	NOUN
dti-1416	92	5	can	can	AUX
dti-1416	92	6	differ	differ	VERB
dti-1416	92	7	in	in	ADP
dti-1416	92	8	multiple	multiple	ADJ
dti-1416	92	9	ways	way	NOUN
dti-1416	92	10	.	.	PUNCT
dti-1416	93	1	genetic	genetic	ADJ
dti-1416	93	2	variation	variation	NOUN
dti-1416	93	3	that	that	PRON
dti-1416	93	4	results	result	VERB
dti-1416	93	5	from	from	ADP
dti-1416	93	6	differences	difference	NOUN
dti-1416	93	7	in	in	ADP
dti-1416	93	8	the	the	DET
dti-1416	93	9	dna	dna	PROPN
dti-1416	93	10	structure	structure	NOUN
dti-1416	93	11	of	of	ADP
dti-1416	93	12	a	a	DET
dti-1416	93	13	gene	gene	NOUN
dti-1416	93	14	or	or	CCONJ
dti-1416	93	15	regulatory	regulatory	ADJ
dti-1416	93	16	portions	portion	NOUN
dti-1416	93	17	of	of	ADP
dti-1416	93	18	the	the	DET
dti-1416	93	19	genome	genome	NOUN
dti-1416	93	20	can	can	AUX
dti-1416	93	21	be	be	AUX
dti-1416	93	22	caused	cause	VERB
dti-1416	93	23	by	by	ADP
dti-1416	93	24	deletions	deletion	NOUN
dti-1416	93	25	,	,	PUNCT
dti-1416	93	26	insertions	insertion	NOUN
dti-1416	93	27	,	,	PUNCT
dti-1416	93	28	duplications	duplication	NOUN
dti-1416	93	29	,	,	PUNCT
dti-1416	93	30	inversions	inversion	NOUN
dti-1416	93	31	,	,	PUNCT
dti-1416	93	32	or	or	CCONJ
dti-1416	93	33	substitutions	substitution	NOUN
dti-1416	93	34	of	of	ADP
dti-1416	93	35	nitrogenous	nitrogenous	ADJ
dti-1416	93	36	bases	basis	NOUN
dti-1416	93	37	within	within	ADP
dti-1416	93	38	the	the	DET
dti-1416	93	39	usual	usual	ADJ
dti-1416	93	40	sequence	sequence	NOUN
dti-1416	93	41	,	,	PUNCT
dti-1416	93	42	thus	thus	ADV
dti-1416	93	43	changing	change	VERB
dti-1416	93	44	the	the	DET
dti-1416	93	45	genetic	genetic	ADJ
dti-1416	93	46	code	code	NOUN
dti-1416	93	47	and	and	CCONJ
dti-1416	93	48	possibly	possibly	ADV
dti-1416	93	49	the	the	DET
dti-1416	93	50	proteins	protein	NOUN
dti-1416	93	51	produced	produce	VERB
dti-1416	93	52	.	.	PUNCT
dti-1416	94	1	a	a	DET
dti-1416	94	2	single	single	ADJ
dti-1416	94	3	-	-	PUNCT
dti-1416	94	4	nucleotide	nucleotide	NOUN
dti-1416	94	5	polymorphism	polymorphism	NOUN
dti-1416	94	6	(	(	PUNCT
dti-1416	94	7	snp	snp	ADJ
dti-1416	94	8	,	,	PUNCT
dti-1416	94	9	“	"	PUNCT
dti-1416	94	10	snip	snip	NOUN
dti-1416	94	11	”	"	PUNCT
dti-1416	94	12	)	)	PUNCT
dti-1416	94	13	occurs	occur	VERB
dti-1416	94	14	when	when	SCONJ
dti-1416	94	15	1	1	NUM
dti-1416	94	16	nitrogenous	nitrogenous	ADJ
dti-1416	94	17	base	base	NOUN
dti-1416	94	18	,	,	PUNCT
dti-1416	94	19	along	along	ADP
dti-1416	94	20	with	with	ADP
dti-1416	94	21	its	its	PRON
dti-1416	94	22	paired	pair	VERB
dti-1416	94	23	complement	complement	NOUN
dti-1416	94	24	,	,	PUNCT
dti-1416	94	25	is	be	AUX
dti-1416	94	26	substituted	substitute	VERB
dti-1416	94	27	within	within	ADP
dti-1416	94	28	the	the	DET
dti-1416	94	29	nucleotide	nucleotide	ADJ
dti-1416	94	30	sequence	sequence	NOUN
dti-1416	94	31	.	.	PUNCT
dti-1416	95	1	single	single	ADJ
dti-1416	95	2	-	-	PUNCT
dti-1416	95	3	nucleotide	nucleotide	NOUN
dti-1416	95	4	polymorphisms	polymorphism	NOUN
dti-1416	95	5	can	can	AUX
dti-1416	95	6	be	be	AUX
dti-1416	95	7	conceptualized	conceptualize	VERB
dti-1416	95	8	as	as	ADP
dti-1416	95	9	misspellings	misspelling	NOUN
dti-1416	95	10	or	or	CCONJ
dti-1416	95	11	“	"	PUNCT
dti-1416	95	12	typos	typos	PROPN
dti-1416	95	13	”	"	PUNCT
dti-1416	95	14	in	in	ADP
dti-1416	95	15	the	the	DET
dti-1416	95	16	usual	usual	ADJ
dti-1416	95	17	order	order	NOUN
dti-1416	95	18	of	of	ADP
dti-1416	95	19	bases	basis	NOUN
dti-1416	95	20	.	.	PUNCT
dti-1416	96	1	a	a	DET
dti-1416	96	2	snp	snp	NOUN
dti-1416	96	3	can	can	AUX
dti-1416	96	4	become	become	VERB
dti-1416	96	5	consequential	consequential	ADJ
dti-1416	96	6	if	if	SCONJ
dti-1416	96	7	it	it	PRON
dti-1416	96	8	occurs	occur	VERB
dti-1416	96	9	within	within	ADP
dti-1416	96	10	a	a	DET
dti-1416	96	11	gene	gene	NOUN
dti-1416	96	12	or	or	CCONJ
dti-1416	96	13	regulatory	regulatory	ADJ
dti-1416	96	14	region	region	NOUN
dti-1416	96	15	,	,	PUNCT
dti-1416	96	16	and	and	CCONJ
dti-1416	96	17	alters	alter	VERB
dti-1416	96	18	the	the	DET
dti-1416	96	19	function	function	NOUN
dti-1416	96	20	of	of	ADP
dti-1416	96	21	the	the	DET
dti-1416	96	22	protein	protein	NOUN
dti-1416	96	23	produced	produce	VERB
dti-1416	96	24	or	or	CCONJ
dti-1416	96	25	disrupts	disrupt	VERB
dti-1416	96	26	the	the	DET
dti-1416	96	27	usual	usual	ADJ
dti-1416	96	28	recipe	recipe	NOUN
dti-1416	96	29	so	so	SCONJ
dti-1416	96	30	that	that	SCONJ
dti-1416	96	31	no	no	DET
dti-1416	96	32	protein	protein	NOUN
dti-1416	96	33	is	be	AUX
dti-1416	96	34	produced	produce	VERB
dti-1416	96	35	at	at	ADV
dti-1416	96	36	all	all	ADV
dti-1416	96	37	.	.	PUNCT
dti-1416	97	1	for	for	ADP
dti-1416	97	2	example	example	NOUN
dti-1416	97	3	,	,	PUNCT
dti-1416	97	4	an	an	DET
dti-1416	97	5	allele	allele	NOUN
dti-1416	97	6	of	of	ADP
dti-1416	97	7	the	the	DET
dti-1416	97	8	4	4	NUM
dti-1416	97	9	drug	drug	NOUN
dti-1416	97	10	target	target	NOUN
dti-1416	97	11	insights	insight	NOUN
dti-1416	97	12	cyp2c19	cyp2c19	NOUN
dti-1416	97	13	gene	gene	NOUN
dti-1416	97	14	named	name	VERB
dti-1416	97	15	cyp2c19	cyp2c19	PROPN
dti-1416	97	16	*	*	PROPN
dti-1416	97	17	2a	2a	NUM
dti-1416	97	18	(	(	PUNCT
dti-1416	97	19	“	"	PUNCT
dti-1416	97	20	star	star	NOUN
dti-1416	97	21	2a	2a	NUM
dti-1416	97	22	”	"	PUNCT
dti-1416	97	23	)	)	PUNCT
dti-1416	97	24	results	result	NOUN
dti-1416	97	25	from	from	ADP
dti-1416	97	26	a	a	DET
dti-1416	97	27	substitution	substitution	NOUN
dti-1416	97	28	of	of	ADP
dti-1416	97	29	an	an	DET
dti-1416	97	30	adenine	adenine	NOUN
dti-1416	97	31	instead	instead	ADV
dti-1416	97	32	of	of	ADP
dti-1416	97	33	a	a	DET
dti-1416	97	34	guanine	guanine	NOUN
dti-1416	97	35	at	at	ADP
dti-1416	97	36	exon	exon	NOUN
dti-1416	97	37	position	position	NOUN
dti-1416	97	38	681	681	NUM
dti-1416	97	39	(	(	PUNCT
dti-1416	97	40	noted	note	VERB
dti-1416	97	41	as	as	ADP
dti-1416	97	42	681g	681g	NOUN
dti-1416	97	43	>	>	X
dti-1416	97	44	a	a	NOUN
dti-1416	97	45	)	)	PUNCT
dti-1416	97	46	and	and	CCONJ
dti-1416	97	47	results	result	NOUN
dti-1416	97	48	in	in	ADP
dti-1416	97	49	a	a	DET
dti-1416	97	50	non	non	ADJ
dti-1416	97	51	-	-	ADJ
dti-1416	97	52	functioning	functioning	ADJ
dti-1416	97	53	enzyme.12	enzyme.12	NOUN
dti-1416	97	54	several	several	ADJ
dti-1416	97	55	drugs	drug	NOUN
dti-1416	97	56	,	,	PUNCT
dti-1416	97	57	including	include	VERB
dti-1416	97	58	the	the	DET
dti-1416	97	59	anti	anti	ADJ
dti-1416	97	60	-	-	ADJ
dti-1416	97	61	platelet	platelet	ADJ
dti-1416	97	62	agent	agent	NOUN
dti-1416	97	63	clopidogrel	clopidogrel	NOUN
dti-1416	97	64	,	,	PUNCT
dti-1416	97	65	require	require	VERB
dti-1416	97	66	cyp2c19	cyp2c19	NOUN
dti-1416	97	67	for	for	ADP
dti-1416	97	68	bioactivation	bioactivation	NOUN
dti-1416	97	69	to	to	ADP
dti-1416	97	70	an	an	DET
dti-1416	97	71	active	active	ADJ
dti-1416	97	72	metabolite	metabolite	NOUN
dti-1416	97	73	to	to	PART
dti-1416	97	74	be	be	AUX
dti-1416	97	75	fully	fully	ADV
dti-1416	97	76	effective	effective	ADJ
dti-1416	97	77	.	.	PUNCT
dti-1416	98	1	people	people	NOUN
dti-1416	98	2	receiving	receive	VERB
dti-1416	98	3	clopidogrel	clopidogrel	NOUN
dti-1416	98	4	,	,	PUNCT
dti-1416	98	5	whose	whose	DET
dti-1416	98	6	genotype	genotype	NOUN
dti-1416	98	7	includes	include	VERB
dti-1416	98	8	1	1	NUM
dti-1416	98	9	or	or	CCONJ
dti-1416	98	10	2	2	NUM
dti-1416	98	11	no	no	PRON
dti-1416	98	12	function	function	NOUN
dti-1416	98	13	alleles	allele	NOUN
dti-1416	98	14	such	such	ADJ
dti-1416	98	15	as	as	ADP
dti-1416	98	16	cyp2c19	cyp2c19	NOUN
dti-1416	98	17	*	*	NOUN
dti-1416	98	18	2a	2a	NUM
dti-1416	98	19	,	,	PUNCT
dti-1416	98	20	are	be	AUX
dti-1416	98	21	classified	classify	VERB
dti-1416	98	22	as	as	ADP
dti-1416	98	23	poor	poor	ADJ
dti-1416	98	24	metabolizers	metabolizer	NOUN
dti-1416	98	25	(	(	PUNCT
dti-1416	98	26	pms	pm	NOUN
dti-1416	98	27	)	)	PUNCT
dti-1416	98	28	of	of	ADP
dti-1416	98	29	the	the	DET
dti-1416	98	30	drug	drug	NOUN
dti-1416	98	31	.	.	PUNCT
dti-1416	99	1	the	the	DET
dti-1416	99	2	fda	fda	PROPN
dti-1416	99	3	-	-	PUNCT
dti-1416	99	4	approved	approve	VERB
dti-1416	99	5	label	label	NOUN
dti-1416	99	6	for	for	ADP
dti-1416	99	7	clopidogrel	clopidogrel	NOUN
dti-1416	99	8	recommends	recommend	VERB
dti-1416	99	9	that	that	SCONJ
dti-1416	99	10	people	people	NOUN
dti-1416	99	11	who	who	PRON
dti-1416	99	12	are	be	AUX
dti-1416	99	13	pms	pms	NOUN
dti-1416	99	14	consider	consider	VERB
dti-1416	99	15	use	use	NOUN
dti-1416	99	16	of	of	ADP
dti-1416	99	17	an	an	DET
dti-1416	99	18	alternative	alternative	ADJ
dti-1416	99	19	platelet	platelet	NOUN
dti-1416	99	20	p2y12	p2y12	NOUN
dti-1416	99	21	inhibitor	inhibitor	NOUN
dti-1416	99	22	to	to	PART
dti-1416	99	23	avoid	avoid	VERB
dti-1416	99	24	poor	poor	ADJ
dti-1416	99	25	outcomes.13	outcomes.13	NOUN
dti-1416	99	26	copy	copy	NOUN
dti-1416	99	27	number	number	NOUN
dti-1416	99	28	variation	variation	NOUN
dti-1416	99	29	(	(	PUNCT
dti-1416	99	30	cnv	cnv	NOUN
dti-1416	99	31	)	)	PUNCT
dti-1416	99	32	occurs	occur	VERB
dti-1416	99	33	when	when	SCONJ
dti-1416	99	34	sections	section	NOUN
dti-1416	99	35	of	of	ADP
dti-1416	99	36	the	the	DET
dti-1416	99	37	usual	usual	ADJ
dti-1416	99	38	dna	dna	NOUN
dti-1416	99	39	sequence	sequence	NOUN
dti-1416	99	40	either	either	CCONJ
dti-1416	99	41	repeat	repeat	VERB
dti-1416	99	42	multiple	multiple	ADJ
dti-1416	99	43	times	time	NOUN
dti-1416	99	44	or	or	CCONJ
dti-1416	99	45	are	be	AUX
dti-1416	99	46	deleted	delete	VERB
dti-1416	99	47	and	and	CCONJ
dti-1416	99	48	do	do	AUX
dti-1416	99	49	not	not	PART
dti-1416	99	50	occur	occur	VERB
dti-1416	99	51	at	at	ADP
dti-1416	99	52	all.14	all.14	PRON
dti-1416	99	53	copy	copy	NOUN
dti-1416	99	54	number	number	NOUN
dti-1416	99	55	variations	variation	NOUN
dti-1416	99	56	become	become	VERB
dti-1416	99	57	significant	significant	ADJ
dti-1416	99	58	when	when	SCONJ
dti-1416	99	59	they	they	PRON
dti-1416	99	60	encompass	encompass	VERB
dti-1416	99	61	a	a	DET
dti-1416	99	62	regulatory	regulatory	ADJ
dti-1416	99	63	or	or	CCONJ
dti-1416	99	64	coding	code	VERB
dti-1416	99	65	section	section	NOUN
dti-1416	99	66	of	of	ADP
dti-1416	99	67	a	a	DET
dti-1416	99	68	gene	gene	NOUN
dti-1416	99	69	.	.	PUNCT
dti-1416	100	1	when	when	SCONJ
dti-1416	100	2	cnv	cnv	PROPN
dti-1416	100	3	leads	lead	VERB
dti-1416	100	4	to	to	ADP
dti-1416	100	5	greater	great	ADJ
dti-1416	100	6	than	than	ADP
dti-1416	100	7	2	2	NUM
dti-1416	100	8	copies	copy	NOUN
dti-1416	100	9	of	of	ADP
dti-1416	100	10	a	a	DET
dti-1416	100	11	gene	gene	NOUN
dti-1416	100	12	,	,	PUNCT
dti-1416	100	13	the	the	DET
dti-1416	100	14	encoded	encode	VERB
dti-1416	100	15	protein	protein	NOUN
dti-1416	100	16	may	may	AUX
dti-1416	100	17	be	be	AUX
dti-1416	100	18	produced	produce	VERB
dti-1416	100	19	in	in	ADP
dti-1416	100	20	greater	great	ADJ
dti-1416	100	21	amounts	amount	NOUN
dti-1416	100	22	and	and	CCONJ
dti-1416	100	23	enzymatic	enzymatic	ADJ
dti-1416	100	24	activity	activity	NOUN
dti-1416	100	25	increased	increase	VERB
dti-1416	100	26	.	.	PUNCT
dti-1416	101	1	a	a	DET
dti-1416	101	2	cnv	cnv	NOUN
dti-1416	101	3	,	,	PUNCT
dti-1416	101	4	that	that	PRON
dti-1416	101	5	results	result	VERB
dti-1416	101	6	in	in	ADP
dti-1416	101	7	multiple	multiple	ADJ
dti-1416	101	8	copies	copy	NOUN
dti-1416	101	9	of	of	ADP
dti-1416	101	10	the	the	DET
dti-1416	101	11	gene	gene	NOUN
dti-1416	101	12	is	be	AUX
dti-1416	101	13	a	a	DET
dti-1416	101	14	multiple	multiple	NOUN
dti-1416	101	15	,	,	PUNCT
dti-1416	101	16	is	be	AUX
dti-1416	101	17	typically	typically	ADV
dti-1416	101	18	noted	note	VERB
dti-1416	101	19	as	as	ADP
dti-1416	101	20	the	the	DET
dti-1416	101	21	gene	gene	NOUN
dti-1416	101	22	symbol	symbol	NOUN
dti-1416	101	23	followed	follow	VERB
dti-1416	101	24	by	by	ADP
dti-1416	101	25	the	the	DET
dti-1416	101	26	allele	allele	PROPN
dti-1416	101	27	star	star	NOUN
dti-1416	101	28	number	number	NOUN
dti-1416	101	29	×	×	PROPN
dti-1416	101	30	n	n	CCONJ
dti-1416	101	31	(	(	PUNCT
dti-1416	101	32	*	*	PROPN
dti-1416	101	33	2	2	NUM
dti-1416	101	34	×	×	NOUN
dti-1416	101	35	n	n	CCONJ
dti-1416	101	36	)	)	PUNCT
dti-1416	101	37	.	.	PUNCT
dti-1416	102	1	if	if	SCONJ
dti-1416	102	2	the	the	DET
dti-1416	102	3	protein	protein	NOUN
dti-1416	102	4	is	be	AUX
dti-1416	102	5	an	an	DET
dti-1416	102	6	enzyme	enzyme	NOUN
dti-1416	102	7	involved	involve	VERB
dti-1416	102	8	in	in	ADP
dti-1416	102	9	drug	drug	NOUN
dti-1416	102	10	metabolism	metabolism	NOUN
dti-1416	102	11	such	such	ADJ
dti-1416	102	12	as	as	ADP
dti-1416	102	13	one	one	NUM
dti-1416	102	14	of	of	ADP
dti-1416	102	15	the	the	DET
dti-1416	102	16	cyp	cyp	ADJ
dti-1416	102	17	p450	p450	PROPN
dti-1416	102	18	enzymes	enzyme	NOUN
dti-1416	102	19	,	,	PUNCT
dti-1416	102	20	increased	increase	VERB
dti-1416	102	21	enzyme	enzyme	NOUN
dti-1416	102	22	activity	activity	NOUN
dti-1416	102	23	can	can	AUX
dti-1416	102	24	result	result	VERB
dti-1416	102	25	in	in	ADP
dti-1416	102	26	accelerated	accelerated	ADJ
dti-1416	102	27	metabolism	metabolism	NOUN
dti-1416	102	28	and	and	CCONJ
dti-1416	102	29	altered	alter	VERB
dti-1416	102	30	pharmacokinetics	pharmacokinetic	NOUN
dti-1416	102	31	.	.	PUNCT
dti-1416	103	1	conversely	conversely	ADV
dti-1416	103	2	,	,	PUNCT
dti-1416	103	3	cnv	cnv	PROPN
dti-1416	103	4	can	can	AUX
dti-1416	103	5	also	also	ADV
dti-1416	103	6	lead	lead	VERB
dti-1416	103	7	to	to	ADP
dti-1416	103	8	the	the	DET
dti-1416	103	9	deletion	deletion	NOUN
dti-1416	103	10	or	or	CCONJ
dti-1416	103	11	skipping	skipping	NOUN
dti-1416	103	12	of	of	ADP
dti-1416	103	13	a	a	DET
dti-1416	103	14	gene	gene	NOUN
dti-1416	103	15	leaving	leave	VERB
dti-1416	103	16	an	an	DET
dti-1416	103	17	individual	individual	NOUN
dti-1416	103	18	with	with	ADP
dti-1416	103	19	less	less	ADJ
dti-1416	103	20	than	than	ADP
dti-1416	103	21	2	2	NUM
dti-1416	103	22	copies	copy	NOUN
dti-1416	103	23	.	.	PUNCT
dti-1416	104	1	lacking	lack	VERB
dti-1416	104	2	one	one	NUM
dti-1416	104	3	or	or	CCONJ
dti-1416	104	4	both	both	DET
dti-1416	104	5	copies	copy	NOUN
dti-1416	104	6	of	of	ADP
dti-1416	104	7	a	a	DET
dti-1416	104	8	cyp	cyp	ADJ
dti-1416	104	9	p450	p450	PROPN
dti-1416	104	10	gene	gene	NOUN
dti-1416	104	11	can	can	AUX
dti-1416	104	12	result	result	VERB
dti-1416	104	13	in	in	ADP
dti-1416	104	14	less	less	ADJ
dti-1416	104	15	to	to	ADP
dti-1416	104	16	no	no	DET
dti-1416	104	17	enzyme	enzyme	NOUN
dti-1416	104	18	being	be	AUX
dti-1416	104	19	produced	produce	VERB
dti-1416	104	20	leading	lead	VERB
dti-1416	104	21	to	to	ADP
dti-1416	104	22	poor	poor	ADJ
dti-1416	104	23	drug	drug	NOUN
dti-1416	104	24	metabolism	metabolism	NOUN
dti-1416	104	25	.	.	PUNCT
dti-1416	105	1	variation	variation	NOUN
dti-1416	105	2	can	can	AUX
dti-1416	105	3	also	also	ADV
dti-1416	105	4	exist	exist	VERB
dti-1416	105	5	in	in	ADP
dti-1416	105	6	the	the	DET
dti-1416	105	7	factors	factor	NOUN
dti-1416	105	8	that	that	PRON
dti-1416	105	9	regulate	regulate	VERB
dti-1416	105	10	the	the	DET
dti-1416	105	11	expression	expression	NOUN
dti-1416	105	12	of	of	ADP
dti-1416	105	13	genes	gene	NOUN
dti-1416	105	14	but	but	CCONJ
dti-1416	105	15	do	do	AUX
dti-1416	105	16	not	not	PART
dti-1416	105	17	alter	alter	VERB
dti-1416	105	18	the	the	DET
dti-1416	105	19	nucleotide	nucleotide	ADJ
dti-1416	105	20	base	base	NOUN
dti-1416	105	21	sequence	sequence	NOUN
dti-1416	105	22	.	.	PUNCT
dti-1416	106	1	epigenetics	epigenetic	NOUN
dti-1416	106	2	,	,	PUNCT
dti-1416	106	3	meaning	meaning	NOUN
dti-1416	106	4	above	above	ADP
dti-1416	106	5	or	or	CCONJ
dti-1416	106	6	upon	upon	SCONJ
dti-1416	106	7	the	the	DET
dti-1416	106	8	gene	gene	NOUN
dti-1416	106	9	,	,	PUNCT
dti-1416	106	10	is	be	AUX
dti-1416	106	11	the	the	DET
dti-1416	106	12	study	study	NOUN
dti-1416	106	13	of	of	ADP
dti-1416	106	14	factors	factor	NOUN
dti-1416	106	15	and	and	CCONJ
dti-1416	106	16	processes	process	NOUN
dti-1416	106	17	within	within	ADP
dti-1416	106	18	the	the	DET
dti-1416	106	19	cell	cell	NOUN
dti-1416	106	20	or	or	CCONJ
dti-1416	106	21	the	the	DET
dti-1416	106	22	environment	environment	NOUN
dti-1416	106	23	that	that	PRON
dti-1416	106	24	influence	influence	VERB
dti-1416	106	25	the	the	DET
dti-1416	106	26	expression	expression	NOUN
dti-1416	106	27	or	or	CCONJ
dti-1416	106	28	suppression	suppression	NOUN
dti-1416	106	29	of	of	ADP
dti-1416	106	30	the	the	DET
dti-1416	106	31	genes	gene	NOUN
dti-1416	106	32	mapped	map	VERB
dti-1416	106	33	in	in	ADP
dti-1416	106	34	the	the	DET
dti-1416	106	35	dna	dna	PROPN
dti-1416	106	36	sequence	sequence	NOUN
dti-1416	106	37	.	.	PUNCT
dti-1416	107	1	in	in	ADP
dti-1416	107	2	other	other	ADJ
dti-1416	107	3	words	word	NOUN
dti-1416	107	4	,	,	PUNCT
dti-1416	107	5	epigenetic	epigenetic	ADJ
dti-1416	107	6	factors	factor	NOUN
dti-1416	107	7	such	such	ADJ
dti-1416	107	8	as	as	ADP
dti-1416	107	9	methylation	methylation	NOUN
dti-1416	107	10	and	and	CCONJ
dti-1416	107	11	transcription	transcription	NOUN
dti-1416	107	12	factor	factor	NOUN
dti-1416	107	13	proteins	protein	NOUN
dti-1416	107	14	signal	signal	VERB
dti-1416	107	15	the	the	DET
dti-1416	107	16	static	static	ADJ
dti-1416	107	17	dna	dna	PROPN
dti-1416	107	18	blueprint	blueprint	NOUN
dti-1416	107	19	to	to	PART
dti-1416	107	20	turn	turn	VERB
dti-1416	107	21	on	on	ADP
dti-1416	107	22	and	and	CCONJ
dti-1416	107	23	off	off	ADV
dti-1416	107	24	.	.	PUNCT
dti-1416	108	1	an	an	DET
dti-1416	108	2	organization	organization	NOUN
dti-1416	108	3	called	call	VERB
dti-1416	108	4	the	the	DET
dti-1416	108	5	pharmacogene	pharmacogene	NOUN
dti-1416	108	6	variation	variation	NOUN
dti-1416	108	7	consortium	consortium	NOUN
dti-1416	108	8	(	(	PUNCT
dti-1416	108	9	pharmvar.org	pharmvar.org	X
dti-1416	108	10	)	)	PUNCT
dti-1416	108	11	has	have	AUX
dti-1416	108	12	been	be	AUX
dti-1416	108	13	formed	form	VERB
dti-1416	108	14	to	to	PART
dti-1416	108	15	catalog	catalog	VERB
dti-1416	108	16	and	and	CCONJ
dti-1416	108	17	consistently	consistently	ADV
dti-1416	108	18	name	name	VERB
dti-1416	108	19	pharmacogene	pharmacogene	NOUN
dti-1416	108	20	variants	variant	NOUN
dti-1416	108	21	,	,	PUNCT
dti-1416	108	22	especially	especially	ADV
dti-1416	108	23	alleles	allele	NOUN
dti-1416	108	24	of	of	ADP
dti-1416	108	25	the	the	DET
dti-1416	108	26	cyp	cyp	ADJ
dti-1416	108	27	p450	p450	PROPN
dti-1416	108	28	enzymes.15	enzymes.15	NOUN
dti-1416	108	29	as	as	ADP
dti-1416	108	30	clinical	clinical	ADJ
dti-1416	108	31	genetic	genetic	ADJ
dti-1416	108	32	testing	testing	NOUN
dti-1416	108	33	becomes	become	VERB
dti-1416	108	34	widespread	widespread	ADJ
dti-1416	108	35	,	,	PUNCT
dti-1416	108	36	it	it	PRON
dti-1416	108	37	is	be	AUX
dti-1416	108	38	important	important	ADJ
dti-1416	108	39	for	for	SCONJ
dti-1416	108	40	researchers	researcher	NOUN
dti-1416	108	41	and	and	CCONJ
dti-1416	108	42	providers	provider	NOUN
dti-1416	108	43	to	to	PART
dti-1416	108	44	communicate	communicate	VERB
dti-1416	108	45	pgx	pgx	PROPN
dti-1416	108	46	results	result	NOUN
dti-1416	108	47	in	in	ADP
dti-1416	108	48	an	an	DET
dti-1416	108	49	accurate	accurate	ADJ
dti-1416	108	50	and	and	CCONJ
dti-1416	108	51	standardized	standardized	ADJ
dti-1416	108	52	manner	manner	NOUN
dti-1416	108	53	.	.	PUNCT
dti-1416	109	1	as	as	ADP
dti-1416	109	2	in	in	ADP
dti-1416	109	3	the	the	DET
dti-1416	109	4	above	above	ADJ
dti-1416	109	5	example	example	NOUN
dti-1416	109	6	,	,	PUNCT
dti-1416	109	7	variants	variant	NOUN
dti-1416	109	8	of	of	ADP
dti-1416	109	9	the	the	DET
dti-1416	109	10	cyp	cyp	ADJ
dti-1416	109	11	p450	p450	PROPN
dti-1416	109	12	enzymes	enzyme	NOUN
dti-1416	109	13	are	be	AUX
dti-1416	109	14	customarily	customarily	ADV
dti-1416	109	15	named	name	VERB
dti-1416	109	16	using	use	VERB
dti-1416	109	17	star	star	NOUN
dti-1416	109	18	-	-	PUNCT
dti-1416	109	19	allele	allele	NOUN
dti-1416	109	20	nomenclature	nomenclature	NOUN
dti-1416	109	21	where	where	SCONJ
dti-1416	109	22	the	the	DET
dti-1416	109	23	gene	gene	NOUN
dti-1416	109	24	symbol	symbol	NOUN
dti-1416	109	25	is	be	AUX
dti-1416	109	26	followed	follow	VERB
dti-1416	109	27	by	by	ADP
dti-1416	109	28	an	an	DET
dti-1416	109	29	asterisk	asterisk	NOUN
dti-1416	109	30	and	and	CCONJ
dti-1416	109	31	a	a	DET
dti-1416	109	32	variant	variant	ADJ
dti-1416	109	33	number	number	NOUN
dti-1416	109	34	.	.	PUNCT
dti-1416	110	1	pharmvar	pharmvar	NOUN
dti-1416	110	2	will	will	AUX
dti-1416	110	3	expand	expand	VERB
dti-1416	110	4	upon	upon	SCONJ
dti-1416	110	5	this	this	DET
dti-1416	110	6	convention	convention	NOUN
dti-1416	110	7	and	and	CCONJ
dti-1416	110	8	also	also	ADV
dti-1416	110	9	serve	serve	VERB
dti-1416	110	10	as	as	ADP
dti-1416	110	11	a	a	DET
dti-1416	110	12	repository	repository	NOUN
dti-1416	110	13	for	for	ADP
dti-1416	110	14	phenotypic	phenotypic	ADJ
dti-1416	110	15	information	information	NOUN
dti-1416	110	16	on	on	ADP
dti-1416	110	17	pharmacogenes	pharmacogene	NOUN
dti-1416	110	18	.	.	PUNCT
dti-1416	111	1	variant	variant	ADJ
dti-1416	111	2	tables	table	NOUN
dti-1416	111	3	for	for	ADP
dti-1416	111	4	the	the	DET
dti-1416	111	5	polymorphic	polymorphic	ADJ
dti-1416	111	6	cyp2c9	cyp2c9	NOUN
dti-1416	111	7	,	,	PUNCT
dti-1416	111	8	cyp2c19	cyp2c19	PROPN
dti-1416	111	9	,	,	PUNCT
dti-1416	111	10	and	and	CCONJ
dti-1416	111	11	cyp2d6	cyp2d6	NOUN
dti-1416	111	12	genes	gene	NOUN
dti-1416	111	13	are	be	AUX
dti-1416	111	14	posted	post	VERB
dti-1416	111	15	in	in	ADP
dti-1416	111	16	the	the	DET
dti-1416	111	17	pharmvar	pharmvar	NOUN
dti-1416	111	18	database	database	NOUN
dti-1416	111	19	and	and	CCONJ
dti-1416	111	20	include	include	VERB
dti-1416	111	21	the	the	DET
dti-1416	111	22	corresponding	corresponding	ADJ
dti-1416	111	23	phenotypic	phenotypic	ADJ
dti-1416	111	24	enzyme	enzyme	NOUN
dti-1416	111	25	activity	activity	NOUN
dti-1416	111	26	level.16	level.16	NOUN
dti-1416	111	27	clinically	clinically	ADV
dti-1416	111	28	actionable	actionable	ADJ
dti-1416	111	29	pharmacogene	pharmacogene	NOUN
dti-1416	111	30	variation	variation	NOUN
dti-1416	111	31	generally	generally	ADV
dti-1416	111	32	,	,	PUNCT
dti-1416	111	33	a	a	DET
dti-1416	111	34	gene	gene	NOUN
dti-1416	111	35	-	-	PUNCT
dti-1416	111	36	drug	drug	NOUN
dti-1416	111	37	association	association	NOUN
dti-1416	111	38	is	be	AUX
dti-1416	111	39	considered	consider	VERB
dti-1416	111	40	clinically	clinically	ADV
dti-1416	111	41	actionable	actionable	ADJ
dti-1416	111	42	if	if	SCONJ
dti-1416	111	43	information	information	NOUN
dti-1416	111	44	about	about	ADP
dti-1416	111	45	genetic	genetic	ADJ
dti-1416	111	46	testing	testing	NOUN
dti-1416	111	47	is	be	AUX
dti-1416	111	48	included	include	VERB
dti-1416	111	49	in	in	ADP
dti-1416	111	50	the	the	DET
dti-1416	111	51	fda	fda	PROPN
dti-1416	111	52	-	-	PUNCT
dti-1416	111	53	approved	approve	VERB
dti-1416	111	54	labeling	labeling	NOUN
dti-1416	111	55	.	.	PUNCT
dti-1416	112	1	currently	currently	ADV
dti-1416	112	2	,	,	PUNCT
dti-1416	112	3	multiple	multiple	ADJ
dti-1416	112	4	gene	gene	NOUN
dti-1416	112	5	-	-	PUNCT
dti-1416	112	6	drug	drug	NOUN
dti-1416	112	7	associations	association	NOUN
dti-1416	112	8	that	that	PRON
dti-1416	112	9	are	be	AUX
dti-1416	112	10	clinically	clinically	ADV
dti-1416	112	11	actionable	actionable	ADJ
dti-1416	112	12	for	for	SCONJ
dti-1416	112	13	pharmacists	pharmacist	NOUN
dti-1416	112	14	involve	involve	VERB
dti-1416	112	15	the	the	DET
dti-1416	112	16	cyp	cyp	ADJ
dti-1416	112	17	p450	p450	NUM
dti-1416	112	18	enzymes	enzyme	NOUN
dti-1416	112	19	.	.	PUNCT
dti-1416	113	1	variation	variation	NOUN
dti-1416	113	2	in	in	ADP
dti-1416	113	3	the	the	DET
dti-1416	113	4	dna	dna	PROPN
dti-1416	113	5	nitrogenous	nitrogenous	ADJ
dti-1416	113	6	base	base	NOUN
dti-1416	113	7	sequence	sequence	NOUN
dti-1416	113	8	can	can	AUX
dti-1416	113	9	produce	produce	VERB
dti-1416	113	10	different	different	ADJ
dti-1416	113	11	versions	version	NOUN
dti-1416	113	12	(	(	PUNCT
dti-1416	113	13	alleles	allele	NOUN
dti-1416	113	14	)	)	PUNCT
dti-1416	113	15	of	of	ADP
dti-1416	113	16	the	the	DET
dti-1416	113	17	cyp2c9	cyp2c9	NOUN
dti-1416	113	18	,	,	PUNCT
dti-1416	113	19	cyp2c19	cyp2c19	PROPN
dti-1416	113	20	,	,	PUNCT
dti-1416	113	21	and	and	CCONJ
dti-1416	113	22	cyp2d6	cyp2d6	NOUN
dti-1416	113	23	genes.17	genes.17	PROPN
dti-1416	113	24	several	several	ADJ
dti-1416	113	25	known	know	VERB
dti-1416	113	26	gene	gene	NOUN
dti-1416	113	27	variants	variant	NOUN
dti-1416	113	28	in	in	ADP
dti-1416	113	29	turn	turn	NOUN
dti-1416	113	30	produce	produce	VERB
dti-1416	113	31	cyp	cyp	ADJ
dti-1416	113	32	p450	p450	NUM
dti-1416	113	33	enzymes	enzyme	NOUN
dti-1416	113	34	that	that	PRON
dti-1416	113	35	differ	differ	VERB
dti-1416	113	36	in	in	ADP
dti-1416	113	37	the	the	DET
dti-1416	113	38	extent	extent	NOUN
dti-1416	113	39	of	of	ADP
dti-1416	113	40	enzyme	enzyme	NOUN
dti-1416	113	41	activity	activity	NOUN
dti-1416	113	42	or	or	CCONJ
dti-1416	113	43	amount	amount	NOUN
dti-1416	113	44	produced	produce	VERB
dti-1416	113	45	,	,	PUNCT
dti-1416	113	46	and	and	CCONJ
dti-1416	113	47	therefore	therefore	ADV
dti-1416	113	48	in	in	ADP
dti-1416	113	49	their	their	PRON
dti-1416	113	50	ability	ability	NOUN
dti-1416	113	51	to	to	PART
dti-1416	113	52	metabolize	metabolize	VERB
dti-1416	113	53	drugs	drug	NOUN
dti-1416	113	54	.	.	PUNCT
dti-1416	114	1	knowing	know	VERB
dti-1416	114	2	the	the	DET
dti-1416	114	3	genotype	genotype	NOUN
dti-1416	114	4	or	or	CCONJ
dti-1416	114	5	the	the	DET
dti-1416	114	6	2	2	NUM
dti-1416	114	7	gene	gene	NOUN
dti-1416	114	8	alleles	allele	NOUN
dti-1416	114	9	a	a	DET
dti-1416	114	10	person	person	NOUN
dti-1416	114	11	inherits	inherit	VERB
dti-1416	114	12	gives	give	VERB
dti-1416	114	13	the	the	DET
dti-1416	114	14	pharmacist	pharmacist	NOUN
dti-1416	114	15	additional	additional	ADJ
dti-1416	114	16	information	information	NOUN
dti-1416	114	17	to	to	PART
dti-1416	114	18	consider	consider	VERB
dti-1416	114	19	when	when	SCONJ
dti-1416	114	20	selecting	select	VERB
dti-1416	114	21	or	or	CCONJ
dti-1416	114	22	dosing	dose	VERB
dti-1416	114	23	drugs	drug	NOUN
dti-1416	114	24	.	.	PUNCT
dti-1416	115	1	to	to	PART
dti-1416	115	2	illustrate	illustrate	VERB
dti-1416	115	3	several	several	ADJ
dti-1416	115	4	of	of	ADP
dti-1416	115	5	these	these	DET
dti-1416	115	6	concepts	concept	NOUN
dti-1416	115	7	,	,	PUNCT
dti-1416	115	8	let	let	VERB
dti-1416	115	9	us	we	PRON
dti-1416	115	10	examine	examine	VERB
dti-1416	115	11	how	how	SCONJ
dti-1416	115	12	cyp2d6	cyp2d6	NOUN
dti-1416	115	13	gene	gene	NOUN
dti-1416	115	14	variation	variation	NOUN
dti-1416	115	15	relates	relate	VERB
dti-1416	115	16	to	to	ADP
dti-1416	115	17	both	both	DET
dti-1416	115	18	the	the	DET
dti-1416	115	19	effectiveness	effectiveness	NOUN
dti-1416	115	20	and	and	CCONJ
dti-1416	115	21	safety	safety	NOUN
dti-1416	115	22	of	of	ADP
dti-1416	115	23	the	the	DET
dti-1416	115	24	opioid	opioid	ADJ
dti-1416	115	25	analgesic	analgesic	ADJ
dti-1416	115	26	drug	drug	NOUN
dti-1416	115	27	codeine	codeine	NOUN
dti-1416	115	28	.	.	PUNCT
dti-1416	116	1	cyp2d6	cyp2d6	NOUN
dti-1416	116	2	polymorphism	polymorphism	NOUN
dti-1416	116	3	the	the	DET
dti-1416	116	4	cyp2d6	cyp2d6	NOUN
dti-1416	116	5	enzyme	enzyme	NOUN
dti-1416	116	6	participates	participate	VERB
dti-1416	116	7	in	in	ADP
dti-1416	116	8	the	the	DET
dti-1416	116	9	metabolism	metabolism	NOUN
dti-1416	116	10	of	of	ADP
dti-1416	116	11	approximately	approximately	ADV
dti-1416	116	12	25	25	NUM
dti-1416	116	13	%	%	NOUN
dti-1416	116	14	of	of	ADP
dti-1416	116	15	all	all	DET
dti-1416	116	16	drugs	drug	NOUN
dti-1416	116	17	,	,	PUNCT
dti-1416	116	18	including	include	VERB
dti-1416	116	19	the	the	DET
dti-1416	116	20	bioactivation	bioactivation	NOUN
dti-1416	116	21	of	of	ADP
dti-1416	116	22	codeine	codeine	NOUN
dti-1416	116	23	,	,	PUNCT
dti-1416	116	24	tramadol	tramadol	NOUN
dti-1416	116	25	,	,	PUNCT
dti-1416	116	26	and	and	CCONJ
dti-1416	116	27	several	several	ADJ
dti-1416	116	28	other	other	ADJ
dti-1416	116	29	pro	pro	ADJ
dti-1416	116	30	-	-	NOUN
dti-1416	116	31	drugs	drug	NOUN
dti-1416	116	32	.	.	PUNCT
dti-1416	117	1	the	the	DET
dti-1416	117	2	cyp2d6	cyp2d6	NOUN
dti-1416	117	3	gene	gene	NOUN
dti-1416	117	4	located	locate	VERB
dti-1416	117	5	on	on	ADP
dti-1416	117	6	chromosome	chromosome	NOUN
dti-1416	117	7	22	22	NUM
dti-1416	117	8	is	be	AUX
dti-1416	117	9	highly	highly	ADV
dti-1416	117	10	polymorphic	polymorphic	ADJ
dti-1416	117	11	and	and	CCONJ
dti-1416	117	12	over	over	ADP
dti-1416	117	13	90	90	NUM
dti-1416	117	14	known	know	VERB
dti-1416	117	15	variants	variant	NOUN
dti-1416	117	16	or	or	CCONJ
dti-1416	117	17	alleles	allele	NOUN
dti-1416	117	18	have	have	AUX
dti-1416	117	19	been	be	AUX
dti-1416	117	20	identified	identify	VERB
dti-1416	117	21	which	which	PRON
dti-1416	117	22	encode	encode	VERB
dti-1416	117	23	for	for	ADP
dti-1416	117	24	multiple	multiple	ADJ
dti-1416	117	25	forms	form	NOUN
dti-1416	117	26	of	of	ADP
dti-1416	117	27	the	the	DET
dti-1416	117	28	enzyme.18	enzyme.18	NOUN
dti-1416	117	29	for	for	ADP
dti-1416	117	30	many	many	ADJ
dti-1416	117	31	of	of	ADP
dti-1416	117	32	these	these	DET
dti-1416	117	33	alleles	allele	NOUN
dti-1416	117	34	,	,	PUNCT
dti-1416	117	35	a	a	DET
dti-1416	117	36	relationship	relationship	NOUN
dti-1416	117	37	has	have	AUX
dti-1416	117	38	been	be	AUX
dti-1416	117	39	established	establish	VERB
dti-1416	117	40	between	between	ADP
dti-1416	117	41	the	the	DET
dti-1416	117	42	version	version	NOUN
dti-1416	117	43	of	of	ADP
dti-1416	117	44	the	the	DET
dti-1416	117	45	gene	gene	NOUN
dti-1416	117	46	and	and	CCONJ
dti-1416	117	47	the	the	DET
dti-1416	117	48	enzymatic	enzymatic	ADJ
dti-1416	117	49	activity	activity	NOUN
dti-1416	117	50	of	of	ADP
dti-1416	117	51	the	the	DET
dti-1416	117	52	cyp2d6	cyp2d6	NOUN
dti-1416	117	53	protein	protein	NOUN
dti-1416	117	54	produced	produce	VERB
dti-1416	117	55	.	.	PUNCT
dti-1416	118	1	for	for	ADP
dti-1416	118	2	example	example	NOUN
dti-1416	118	3	,	,	PUNCT
dti-1416	118	4	the	the	DET
dti-1416	118	5	cyp2d6	cyp2d6	NOUN
dti-1416	118	6	*	*	SYM
dti-1416	118	7	4	4	NUM
dti-1416	118	8	allele	allele	NOUN
dti-1416	118	9	results	result	NOUN
dti-1416	118	10	from	from	ADP
dti-1416	118	11	a	a	DET
dti-1416	118	12	snp	snp	NOUN
dti-1416	118	13	caused	cause	VERB
dti-1416	118	14	by	by	ADP
dti-1416	118	15	the	the	DET
dti-1416	118	16	substitution	substitution	NOUN
dti-1416	118	17	of	of	ADP
dti-1416	118	18	an	an	DET
dti-1416	118	19	adenine	adenine	NOUN
dti-1416	118	20	instead	instead	ADV
dti-1416	118	21	of	of	ADP
dti-1416	118	22	a	a	DET
dti-1416	118	23	guanine	guanine	NOUN
dti-1416	118	24	(	(	PUNCT
dti-1416	118	25	g	g	NOUN
dti-1416	118	26	>	>	X
dti-1416	118	27	a	a	PRON
dti-1416	118	28	)	)	PUNCT
dti-1416	118	29	,	,	PUNCT
dti-1416	118	30	which	which	DET
dti-1416	118	31	shifts	shift	NOUN
dti-1416	118	32	the	the	DET
dti-1416	118	33	code	code	NOUN
dti-1416	118	34	and	and	CCONJ
dti-1416	118	35	produces	produce	VERB
dti-1416	118	36	a	a	DET
dti-1416	118	37	non	non	ADJ
dti-1416	118	38	-	-	ADJ
dti-1416	118	39	functioning	functioning	ADJ
dti-1416	118	40	enzyme	enzyme	NOUN
dti-1416	118	41	.	.	PUNCT
dti-1416	119	1	the	the	DET
dti-1416	119	2	cyp2d6	cyp2d6	NOUN
dti-1416	119	3	gene	gene	NOUN
dti-1416	119	4	is	be	AUX
dti-1416	119	5	also	also	ADV
dti-1416	119	6	subject	subject	ADJ
dti-1416	119	7	to	to	ADP
dti-1416	119	8	inheritable	inheritable	ADJ
dti-1416	119	9	cnv	cnv	NOUN
dti-1416	119	10	,	,	PUNCT
dti-1416	119	11	which	which	PRON
dti-1416	119	12	can	can	AUX
dti-1416	119	13	include	include	VERB
dti-1416	119	14	both	both	DET
dti-1416	119	15	multiple	multiple	ADJ
dti-1416	119	16	copies	copy	NOUN
dti-1416	119	17	of	of	ADP
dti-1416	119	18	the	the	DET
dti-1416	119	19	gene	gene	NOUN
dti-1416	119	20	or	or	CCONJ
dti-1416	119	21	deletion	deletion	NOUN
dti-1416	119	22	of	of	ADP
dti-1416	119	23	one	one	NUM
dti-1416	119	24	or	or	CCONJ
dti-1416	119	25	both	both	DET
dti-1416	119	26	copies	copy	NOUN
dti-1416	119	27	.	.	PUNCT
dti-1416	120	1	one	one	NUM
dti-1416	120	2	study	study	NOUN
dti-1416	120	3	found	find	VERB
dti-1416	120	4	that	that	SCONJ
dti-1416	120	5	12.6	12.6	NUM
dti-1416	120	6	%	%	NOUN
dti-1416	120	7	of	of	ADP
dti-1416	120	8	30	30	NUM
dti-1416	120	9	000	000	NUM
dti-1416	120	10	patient	patient	NOUN
dti-1416	120	11	samples	sample	NOUN
dti-1416	120	12	tested	test	VERB
dti-1416	120	13	contained	contain	VERB
dti-1416	120	14	0	0	NUM
dti-1416	120	15	,	,	PUNCT
dti-1416	120	16	1	1	NUM
dti-1416	120	17	,	,	PUNCT
dti-1416	120	18	or	or	CCONJ
dti-1416	120	19	3	3	NUM
dti-1416	120	20	or	or	CCONJ
dti-1416	120	21	more	more	ADJ
dti-1416	120	22	copies	copy	NOUN
dti-1416	120	23	of	of	ADP
dti-1416	120	24	the	the	DET
dti-1416	120	25	cyp2d6	cyp2d6	NOUN
dti-1416	120	26	gene.19	gene.19	NOUN
dti-1416	120	27	codeine	codeine	PROPN
dti-1416	120	28	is	be	AUX
dti-1416	120	29	essentially	essentially	ADV
dti-1416	120	30	a	a	DET
dti-1416	120	31	pro	pro	ADJ
dti-1416	120	32	-	-	ADJ
dti-1416	120	33	drug	drug	NOUN
dti-1416	120	34	that	that	PRON
dti-1416	120	35	needs	need	VERB
dti-1416	120	36	the	the	DET
dti-1416	120	37	cyp2d6	cyp2d6	NOUN
dti-1416	120	38	enzyme	enzyme	NOUN
dti-1416	120	39	to	to	PART
dti-1416	120	40	convert	convert	VERB
dti-1416	120	41	5	5	NUM
dti-1416	120	42	%	%	NOUN
dti-1416	120	43	to	to	PART
dti-1416	120	44	10	10	NUM
dti-1416	120	45	%	%	NOUN
dti-1416	120	46	of	of	ADP
dti-1416	120	47	each	each	DET
dti-1416	120	48	dose	dose	NOUN
dti-1416	120	49	to	to	ADP
dti-1416	120	50	morphine	morphine	NOUN
dti-1416	120	51	,	,	PUNCT
dti-1416	120	52	which	which	PRON
dti-1416	120	53	has	have	VERB
dti-1416	120	54	a	a	DET
dti-1416	120	55	200	200	NUM
dti-1416	120	56	times	time	NOUN
dti-1416	120	57	greater	great	ADJ
dti-1416	120	58	affinity	affinity	NOUN
dti-1416	120	59	for	for	ADP
dti-1416	120	60	the	the	DET
dti-1416	120	61	mu	mu	NOUN
dti-1416	120	62	opioid	opioid	ADJ
dti-1416	120	63	receptor	receptor	NOUN
dti-1416	120	64	than	than	SCONJ
dti-1416	120	65	does	do	AUX
dti-1416	120	66	the	the	DET
dti-1416	120	67	parent	parent	NOUN
dti-1416	120	68	compound.20	compound.20	NOUN
dti-1416	120	69	the	the	DET
dti-1416	120	70	balance	balance	NOUN
dti-1416	120	71	between	between	ADP
dti-1416	120	72	adequate	adequate	ADJ
dti-1416	120	73	analgesic	analgesic	ADJ
dti-1416	120	74	effect	effect	NOUN
dti-1416	120	75	and	and	CCONJ
dti-1416	120	76	over	over	ADP
dti-1416	120	77	-	-	PUNCT
dti-1416	120	78	sedation	sedation	NOUN
dti-1416	120	79	is	be	AUX
dti-1416	120	80	dependent	dependent	ADJ
dti-1416	120	81	upon	upon	SCONJ
dti-1416	120	82	an	an	DET
dti-1416	120	83	individual	individual	NOUN
dti-1416	120	84	’s	’s	PART
dti-1416	120	85	cyp2d6	cyp2d6	NOUN
dti-1416	120	86	activity	activity	NOUN
dti-1416	120	87	.	.	PUNCT
dti-1416	121	1	based	base	VERB
dti-1416	121	2	on	on	ADP
dti-1416	121	3	genotype	genotype	NOUN
dti-1416	121	4	(	(	PUNCT
dti-1416	121	5	the	the	DET
dti-1416	121	6	combination	combination	NOUN
dti-1416	121	7	of	of	ADP
dti-1416	121	8	inherited	inherit	VERB
dti-1416	121	9	alleles	allele	NOUN
dti-1416	121	10	)	)	PUNCT
dti-1416	121	11	,	,	PUNCT
dti-1416	121	12	people	people	NOUN
dti-1416	121	13	can	can	AUX
dti-1416	121	14	be	be	AUX
dti-1416	121	15	placed	place	VERB
dti-1416	121	16	into	into	ADP
dti-1416	121	17	1	1	NUM
dti-1416	121	18	of	of	ADP
dti-1416	121	19	4	4	NUM
dti-1416	121	20	phenotypic	phenotypic	ADJ
dti-1416	121	21	categories	category	NOUN
dti-1416	121	22	that	that	PRON
dti-1416	121	23	predict	predict	VERB
dti-1416	121	24	their	their	PRON
dti-1416	121	25	expected	expect	VERB
dti-1416	121	26	level	level	NOUN
dti-1416	121	27	of	of	ADP
dti-1416	121	28	cyp2d6	cyp2d6	NOUN
dti-1416	121	29	enzyme	enzyme	NOUN
dti-1416	121	30	activity	activity	NOUN
dti-1416	121	31	.	.	PUNCT
dti-1416	122	1	variation	variation	NOUN
dti-1416	122	2	in	in	ADP
dti-1416	122	3	the	the	DET
dti-1416	122	4	cyp2d6	cyp2d6	NOUN
dti-1416	122	5	gene	gene	NOUN
dti-1416	122	6	leads	lead	VERB
dti-1416	122	7	to	to	ADP
dti-1416	122	8	a	a	DET
dti-1416	122	9	spectrum	spectrum	NOUN
dti-1416	122	10	of	of	ADP
dti-1416	122	11	enzymatic	enzymatic	ADJ
dti-1416	122	12	activity	activity	NOUN
dti-1416	122	13	that	that	PRON
dti-1416	122	14	ranges	range	VERB
dti-1416	122	15	from	from	ADP
dti-1416	122	16	rapid	rapid	ADJ
dti-1416	122	17	conversion	conversion	NOUN
dti-1416	122	18	of	of	ADP
dti-1416	122	19	codeine	codeine	NOUN
dti-1416	122	20	to	to	PART
dti-1416	122	21	morphine	morphine	VERB
dti-1416	122	22	to	to	ADP
dti-1416	122	23	an	an	DET
dti-1416	122	24	inability	inability	NOUN
dti-1416	122	25	to	to	PART
dti-1416	122	26	metabolize	metabolize	VERB
dti-1416	122	27	codeine	codeine	NOUN
dti-1416	122	28	through	through	ADP
dti-1416	122	29	this	this	DET
dti-1416	122	30	pathway	pathway	NOUN
dti-1416	122	31	.	.	PUNCT
dti-1416	123	1	table	table	NOUN
dti-1416	123	2	1	1	NUM
dti-1416	123	3	shows	show	VERB
dti-1416	123	4	some	some	DET
dti-1416	123	5	common	common	ADJ
dti-1416	123	6	cyp2d6	cyp2d6	NOUN
dti-1416	123	7	alleles	allele	NOUN
dti-1416	123	8	accompanied	accompany	VERB
dti-1416	123	9	with	with	ADP
dti-1416	123	10	the	the	DET
dti-1416	123	11	phenotypic	phenotypic	ADJ
dti-1416	123	12	enzyme	enzyme	NOUN
dti-1416	123	13	activity	activity	NOUN
dti-1416	123	14	level.21	level.21	NOUN
dti-1416	123	15	when	when	SCONJ
dti-1416	123	16	presented	present	VERB
dti-1416	123	17	with	with	ADP
dti-1416	123	18	a	a	DET
dti-1416	123	19	person	person	NOUN
dti-1416	123	20	’s	’s	PART
dti-1416	123	21	genotype	genotype	NOUN
dti-1416	123	22	,	,	PUNCT
dti-1416	123	23	the	the	DET
dti-1416	123	24	phenotype	phenotype	NOUN
dti-1416	123	25	category	category	NOUN
dti-1416	123	26	is	be	AUX
dti-1416	123	27	assigned	assign	VERB
dti-1416	123	28	based	base	VERB
dti-1416	123	29	on	on	ADP
dti-1416	123	30	the	the	DET
dti-1416	123	31	highest	high	ADJ
dti-1416	123	32	functioning	function	VERB
dti-1416	123	33	cyp2d6	cyp2d6	NOUN
dti-1416	123	34	allele	allele	PROPN
dti-1416	123	35	.	.	PUNCT
dti-1416	124	1	people	people	NOUN
dti-1416	124	2	categorized	categorize	VERB
dti-1416	124	3	as	as	ADP
dti-1416	124	4	ultrarapid	ultrarapid	NOUN
dti-1416	124	5	metabolizers	metabolizer	NOUN
dti-1416	124	6	(	(	PUNCT
dti-1416	124	7	ums	ums	PROPN
dti-1416	124	8	)	)	PUNCT
dti-1416	124	9	possess	possess	VERB
dti-1416	124	10	multiple	multiple	ADJ
dti-1416	124	11	copies	copy	NOUN
dti-1416	124	12	(	(	PUNCT
dti-1416	124	13	more	more	ADJ
dti-1416	124	14	than	than	ADP
dti-1416	124	15	2	2	NUM
dti-1416	124	16	)	)	PUNCT
dti-1416	124	17	of	of	ADP
dti-1416	124	18	active	active	ADJ
dti-1416	124	19	alleles	allele	NOUN
dti-1416	124	20	and	and	CCONJ
dti-1416	124	21	express	express	VERB
dti-1416	124	22	greater	great	ADJ
dti-1416	124	23	amounts	amount	NOUN
dti-1416	124	24	of	of	ADP
dti-1416	124	25	the	the	DET
dti-1416	124	26	cyp2d6	cyp2d6	NOUN
dti-1416	124	27	enzyme	enzyme	NOUN
dti-1416	124	28	and	and	CCONJ
dti-1416	124	29	therefore	therefore	ADV
dti-1416	124	30	rapidly	rapidly	ADV
dti-1416	124	31	convert	convert	VERB
dti-1416	124	32	codeine	codeine	NOUN
dti-1416	124	33	to	to	ADP
dti-1416	124	34	morphine	morphine	VERB
dti-1416	124	35	.	.	PUNCT
dti-1416	125	1	an	an	DET
dti-1416	125	2	example	example	NOUN
dti-1416	125	3	genotype	genotype	NOUN
dti-1416	125	4	of	of	ADP
dti-1416	125	5	an	an	DET
dti-1416	125	6	um	um	INTJ
dti-1416	125	7	might	might	AUX
dti-1416	125	8	consist	consist	VERB
dti-1416	125	9	of	of	ADP
dti-1416	125	10	a	a	DET
dti-1416	125	11	*	*	SYM
dti-1416	125	12	1	1	NUM
dti-1416	125	13	allele	allele	NOUN
dti-1416	125	14	(	(	PUNCT
dti-1416	125	15	wild	wild	NOUN
dti-1416	125	16	-	-	PUNCT
dti-1416	125	17	type	type	NOUN
dti-1416	125	18	)	)	PUNCT
dti-1416	125	19	and	and	CCONJ
dti-1416	125	20	the	the	DET
dti-1416	125	21	cnv	cnv	PROPN
dti-1416	125	22	*	*	PROPN
dti-1416	125	23	2	2	NUM
dti-1416	125	24	×	×	NOUN
dti-1416	125	25	n	n	PRON
dti-1416	125	26	(	(	PUNCT
dti-1416	125	27	*	*	NOUN
dti-1416	125	28	1/*2	1/*2	NUM
dti-1416	125	29	×	×	NOUN
dti-1416	125	30	n	n	CCONJ
dti-1416	125	31	)	)	PUNCT
dti-1416	125	32	resulting	result	VERB
dti-1416	125	33	in	in	ADP
dti-1416	125	34	the	the	DET
dti-1416	125	35	production	production	NOUN
dti-1416	125	36	of	of	ADP
dti-1416	125	37	greater	great	ADJ
dti-1416	125	38	than	than	ADP
dti-1416	125	39	normal	normal	ADJ
dti-1416	125	40	amounts	amount	NOUN
dti-1416	125	41	of	of	ADP
dti-1416	125	42	the	the	DET
dti-1416	125	43	cyp2d6	cyp2d6	NOUN
dti-1416	125	44	enzyme	enzyme	NOUN
dti-1416	125	45	activity	activity	NOUN
dti-1416	125	46	.	.	PUNCT
dti-1416	126	1	orrico	orrico	PROPN
dti-1416	126	2	5	5	NUM
dti-1416	126	3	ultrarapid	ultrarapid	NOUN
dti-1416	126	4	metabolizers	metabolizer	NOUN
dti-1416	126	5	can	can	AUX
dti-1416	126	6	experience	experience	VERB
dti-1416	126	7	high	high	ADJ
dti-1416	126	8	blood	blood	NOUN
dti-1416	126	9	levels	level	NOUN
dti-1416	126	10	of	of	ADP
dti-1416	126	11	morphine	morphine	NOUN
dti-1416	126	12	and	and	CCONJ
dti-1416	126	13	if	if	SCONJ
dti-1416	126	14	breastfeeding	breastfeeding	NOUN
dti-1416	126	15	can	can	AUX
dti-1416	126	16	pass	pass	VERB
dti-1416	126	17	excessive	excessive	ADJ
dti-1416	126	18	amounts	amount	NOUN
dti-1416	126	19	to	to	ADP
dti-1416	126	20	a	a	DET
dti-1416	126	21	nursing	nursing	NOUN
dti-1416	126	22	infant	infant	NOUN
dti-1416	126	23	.	.	PUNCT
dti-1416	127	1	at	at	ADP
dti-1416	127	2	the	the	DET
dti-1416	127	3	opposite	opposite	ADJ
dti-1416	127	4	end	end	NOUN
dti-1416	127	5	of	of	ADP
dti-1416	127	6	the	the	DET
dti-1416	127	7	spectrum	spectrum	NOUN
dti-1416	127	8	,	,	PUNCT
dti-1416	127	9	pms	pm	NOUN
dti-1416	127	10	possess	possess	VERB
dti-1416	127	11	2	2	NUM
dti-1416	127	12	no	no	DET
dti-1416	127	13	function	function	NOUN
dti-1416	127	14	alleles	allele	NOUN
dti-1416	127	15	that	that	PRON
dti-1416	127	16	encode	encode	VERB
dti-1416	127	17	for	for	ADP
dti-1416	127	18	cyp2d6	cyp2d6	NOUN
dti-1416	127	19	enzyme	enzyme	NOUN
dti-1416	127	20	that	that	PRON
dti-1416	127	21	is	be	AUX
dti-1416	127	22	inactive	inactive	ADJ
dti-1416	127	23	or	or	CCONJ
dti-1416	127	24	does	do	AUX
dti-1416	127	25	not	not	PART
dti-1416	127	26	get	get	AUX
dti-1416	127	27	produced	produce	VERB
dti-1416	127	28	at	at	ADV
dti-1416	127	29	all	all	ADV
dti-1416	127	30	.	.	PUNCT
dti-1416	128	1	when	when	SCONJ
dti-1416	128	2	given	give	VERB
dti-1416	128	3	usual	usual	ADJ
dti-1416	128	4	doses	dose	NOUN
dti-1416	128	5	of	of	ADP
dti-1416	128	6	codeine	codeine	NOUN
dti-1416	128	7	,	,	PUNCT
dti-1416	128	8	pms	pm	NOUN
dti-1416	128	9	experience	experience	VERB
dti-1416	128	10	little	little	ADJ
dti-1416	128	11	analgesic	analgesic	ADJ
dti-1416	128	12	effect	effect	NOUN
dti-1416	128	13	because	because	SCONJ
dti-1416	128	14	they	they	PRON
dti-1416	128	15	do	do	AUX
dti-1416	128	16	not	not	PART
dti-1416	128	17	convert	convert	VERB
dti-1416	128	18	codeine	codeine	NOUN
dti-1416	128	19	to	to	PART
dti-1416	128	20	morphine	morphine	VERB
dti-1416	128	21	to	to	ADP
dti-1416	128	22	an	an	DET
dti-1416	128	23	appreciable	appreciable	ADJ
dti-1416	128	24	degree	degree	NOUN
dti-1416	128	25	.	.	PUNCT
dti-1416	129	1	extensive	extensive	ADJ
dti-1416	129	2	metabolizer	metabolizer	NOUN
dti-1416	129	3	(	(	PUNCT
dti-1416	129	4	em	em	NOUN
dti-1416	129	5	)	)	PUNCT
dti-1416	129	6	and	and	CCONJ
dti-1416	129	7	intermediate	intermediate	ADJ
dti-1416	129	8	metabolizer	metabolizer	NOUN
dti-1416	129	9	(	(	PUNCT
dti-1416	129	10	i	i	NOUN
dti-1416	129	11	m	m	NOUN
dti-1416	129	12	)	)	PUNCT
dti-1416	129	13	phenotypes	phenotype	NOUN
dti-1416	129	14	are	be	AUX
dti-1416	129	15	often	often	ADV
dti-1416	129	16	grouped	group	VERB
dti-1416	129	17	together	together	ADV
dti-1416	129	18	and	and	CCONJ
dti-1416	129	19	are	be	AUX
dti-1416	129	20	typically	typically	ADV
dti-1416	129	21	considered	consider	VERB
dti-1416	129	22	to	to	PART
dti-1416	129	23	have	have	VERB
dti-1416	129	24	enzyme	enzyme	NOUN
dti-1416	129	25	activity	activity	NOUN
dti-1416	129	26	within	within	ADP
dti-1416	129	27	the	the	DET
dti-1416	129	28	normal	normal	ADJ
dti-1416	129	29	range	range	NOUN
dti-1416	129	30	and	and	CCONJ
dti-1416	129	31	classified	classify	VERB
dti-1416	129	32	as	as	ADP
dti-1416	129	33	normal	normal	ADJ
dti-1416	129	34	metabolizers	metabolizer	NOUN
dti-1416	129	35	(	(	PUNCT
dti-1416	129	36	nms	nms	PROPN
dti-1416	129	37	)	)	PUNCT
dti-1416	129	38	.	.	PUNCT
dti-1416	130	1	an	an	DET
dti-1416	130	2	individual	individual	NOUN
dti-1416	130	3	with	with	ADP
dti-1416	130	4	a	a	DET
dti-1416	130	5	genotype	genotype	NOUN
dti-1416	130	6	of	of	ADP
dti-1416	130	7	*	*	NOUN
dti-1416	130	8	1/*17	1/*17	NUM
dti-1416	130	9	,	,	PUNCT
dti-1416	130	10	for	for	ADP
dti-1416	130	11	example	example	NOUN
dti-1416	130	12	,	,	PUNCT
dti-1416	130	13	would	would	AUX
dti-1416	130	14	be	be	AUX
dti-1416	130	15	classified	classify	VERB
dti-1416	130	16	as	as	ADP
dti-1416	130	17	an	an	DET
dti-1416	130	18	nm	nm	NOUN
dti-1416	130	19	because	because	SCONJ
dti-1416	130	20	they	they	PRON
dti-1416	130	21	possess	possess	VERB
dti-1416	130	22	at	at	ADV
dti-1416	130	23	least	least	ADJ
dti-1416	130	24	1	1	NUM
dti-1416	130	25	normal	normal	ADJ
dti-1416	130	26	function	function	NOUN
dti-1416	130	27	allele	allele	NOUN
dti-1416	130	28	.	.	PUNCT
dti-1416	131	1	intermediate	intermediate	ADJ
dti-1416	131	2	metabolizers	metabolizer	NOUN
dti-1416	131	3	possess	possess	VERB
dti-1416	131	4	a	a	DET
dti-1416	131	5	genotype	genotype	NOUN
dti-1416	131	6	consisting	consist	VERB
dti-1416	131	7	of	of	ADP
dti-1416	131	8	2	2	NUM
dti-1416	131	9	decreased	decrease	VERB
dti-1416	131	10	function	function	NOUN
dti-1416	131	11	alleles	allele	NOUN
dti-1416	131	12	or	or	CCONJ
dti-1416	131	13	1	1	NUM
dti-1416	131	14	decreased	decrease	VERB
dti-1416	131	15	and	and	CCONJ
dti-1416	131	16	1	1	NUM
dti-1416	131	17	no	no	PRON
dti-1416	131	18	function	function	NOUN
dti-1416	131	19	allele	allele	NOUN
dti-1416	131	20	such	such	ADJ
dti-1416	131	21	as	as	ADP
dti-1416	131	22	*	*	PROPN
dti-1416	131	23	9/*41	9/*41	NUM
dti-1416	131	24	or	or	CCONJ
dti-1416	131	25	*	*	NOUN
dti-1416	131	26	9/*3	9/*3	NUM
dti-1416	131	27	.	.	PUNCT
dti-1416	132	1	once	once	SCONJ
dti-1416	132	2	the	the	DET
dti-1416	132	3	cyp2d6	cyp2d6	NOUN
dti-1416	132	4	genotype	genotype	NOUN
dti-1416	132	5	and	and	CCONJ
dti-1416	132	6	metabolizer	metabolizer	NOUN
dti-1416	132	7	class	class	NOUN
dti-1416	132	8	is	be	AUX
dti-1416	132	9	determined	determine	VERB
dti-1416	132	10	,	,	PUNCT
dti-1416	132	11	the	the	DET
dti-1416	132	12	pharmacist	pharmacist	NOUN
dti-1416	132	13	must	must	AUX
dti-1416	132	14	integrate	integrate	VERB
dti-1416	132	15	this	this	DET
dti-1416	132	16	information	information	NOUN
dti-1416	132	17	into	into	ADP
dti-1416	132	18	the	the	DET
dti-1416	132	19	drug	drug	NOUN
dti-1416	132	20	treatment	treatment	NOUN
dti-1416	132	21	plan	plan	NOUN
dti-1416	132	22	.	.	PUNCT
dti-1416	133	1	consulting	consult	VERB
dti-1416	133	2	the	the	DET
dti-1416	133	3	pharmgkb	pharmgkb	NOUN
dti-1416	133	4	is	be	AUX
dti-1416	133	5	a	a	DET
dti-1416	133	6	vital	vital	ADJ
dti-1416	133	7	first	first	ADJ
dti-1416	133	8	step	step	NOUN
dti-1416	133	9	.	.	PUNCT
dti-1416	134	1	pharmgkb.org	pharmgkb.org	PROPN
dti-1416	134	2	provides	provide	VERB
dti-1416	134	3	a	a	DET
dti-1416	134	4	comprehensive	comprehensive	ADJ
dti-1416	134	5	and	and	CCONJ
dti-1416	134	6	easily	easily	ADV
dti-1416	134	7	accessible	accessible	ADJ
dti-1416	134	8	online	online	ADJ
dti-1416	134	9	pgx	pgx	PROPN
dti-1416	134	10	resource	resource	NOUN
dti-1416	134	11	developed	develop	VERB
dti-1416	134	12	and	and	CCONJ
dti-1416	134	13	generously	generously	ADV
dti-1416	134	14	shared	share	VERB
dti-1416	134	15	by	by	ADP
dti-1416	134	16	experts	expert	NOUN
dti-1416	134	17	at	at	ADP
dti-1416	134	18	stanford	stanford	PROPN
dti-1416	134	19	university	university	PROPN
dti-1416	134	20	.	.	PUNCT
dti-1416	135	1	the	the	DET
dti-1416	135	2	mission	mission	NOUN
dti-1416	135	3	of	of	ADP
dti-1416	135	4	pharmgkb	pharmgkb	PROPN
dti-1416	135	5	is	be	AUX
dti-1416	135	6	to	to	PART
dti-1416	135	7	collect	collect	VERB
dti-1416	135	8	,	,	PUNCT
dti-1416	135	9	curate	curate	NOUN
dti-1416	135	10	,	,	PUNCT
dti-1416	135	11	and	and	CCONJ
dti-1416	135	12	disseminate	disseminate	VERB
dti-1416	135	13	knowledge	knowledge	NOUN
dti-1416	135	14	about	about	ADP
dti-1416	135	15	the	the	DET
dti-1416	135	16	impact	impact	NOUN
dti-1416	135	17	of	of	ADP
dti-1416	135	18	human	human	ADJ
dti-1416	135	19	genetic	genetic	ADJ
dti-1416	135	20	variation	variation	NOUN
dti-1416	135	21	on	on	ADP
dti-1416	135	22	drug	drug	NOUN
dti-1416	135	23	response.22	response.22	NOUN
dti-1416	135	24	it	it	PRON
dti-1416	135	25	is	be	AUX
dti-1416	135	26	an	an	DET
dti-1416	135	27	invaluable	invaluable	ADJ
dti-1416	135	28	repository	repository	NOUN
dti-1416	135	29	of	of	ADP
dti-1416	135	30	evidence	evidence	NOUN
dti-1416	135	31	-	-	PUNCT
dti-1416	135	32	based	base	VERB
dti-1416	135	33	pgx	pgx	PROPN
dti-1416	135	34	knowledge	knowledge	NOUN
dti-1416	135	35	that	that	PRON
dti-1416	135	36	is	be	AUX
dti-1416	135	37	organized	organize	VERB
dti-1416	135	38	and	and	CCONJ
dti-1416	135	39	annotated	annotate	VERB
dti-1416	135	40	for	for	ADP
dti-1416	135	41	clinicians	clinician	NOUN
dti-1416	135	42	and	and	CCONJ
dti-1416	135	43	researchers	researcher	NOUN
dti-1416	135	44	alike	alike	ADV
dti-1416	135	45	.	.	PUNCT
dti-1416	136	1	in	in	ADP
dti-1416	136	2	addition	addition	NOUN
dti-1416	136	3	to	to	ADP
dti-1416	136	4	the	the	DET
dti-1416	136	5	aforementioned	aforementioned	ADJ
dti-1416	136	6	list	list	NOUN
dti-1416	136	7	of	of	ADP
dti-1416	136	8	vips	vip	NOUN
dti-1416	136	9	,	,	PUNCT
dti-1416	136	10	pharmgkb	pharmgkb	ADJ
dti-1416	136	11	houses	house	VERB
dti-1416	136	12	clinical	clinical	ADJ
dti-1416	136	13	practice	practice	NOUN
dti-1416	136	14	guidelines	guideline	NOUN
dti-1416	136	15	and	and	CCONJ
dti-1416	136	16	drug	drug	NOUN
dti-1416	136	17	labeling	labeling	NOUN
dti-1416	136	18	information	information	NOUN
dti-1416	136	19	from	from	ADP
dti-1416	136	20	the	the	DET
dti-1416	136	21	united	united	PROPN
dti-1416	136	22	states	states	PROPN
dti-1416	136	23	,	,	PUNCT
dti-1416	136	24	canada	canada	PROPN
dti-1416	136	25	,	,	PUNCT
dti-1416	136	26	japan	japan	PROPN
dti-1416	136	27	,	,	PUNCT
dti-1416	136	28	and	and	CCONJ
dti-1416	136	29	the	the	DET
dti-1416	136	30	netherlands	netherlands	PROPN
dti-1416	136	31	.	.	PUNCT
dti-1416	137	1	navigating	navigate	VERB
dti-1416	137	2	pharmgkb	pharmgkb	NOUN
dti-1416	137	3	can	can	AUX
dti-1416	137	4	be	be	AUX
dti-1416	137	5	as	as	ADV
dti-1416	137	6	simple	simple	ADJ
dti-1416	137	7	as	as	ADP
dti-1416	137	8	entering	enter	VERB
dti-1416	137	9	the	the	DET
dti-1416	137	10	name	name	NOUN
dti-1416	137	11	of	of	ADP
dti-1416	137	12	the	the	DET
dti-1416	137	13	drug	drug	NOUN
dti-1416	137	14	or	or	CCONJ
dti-1416	137	15	gene	gene	NOUN
dti-1416	137	16	into	into	ADP
dti-1416	137	17	the	the	DET
dti-1416	137	18	search	search	NOUN
dti-1416	137	19	field	field	NOUN
dti-1416	137	20	and	and	CCONJ
dti-1416	137	21	arriving	arrive	VERB
dti-1416	137	22	at	at	ADP
dti-1416	137	23	a	a	DET
dti-1416	137	24	monograph	monograph	NOUN
dti-1416	137	25	-	-	PUNCT
dti-1416	137	26	type	type	NOUN
dti-1416	137	27	synopsis	synopsis	NOUN
dti-1416	137	28	with	with	ADP
dti-1416	137	29	a	a	DET
dti-1416	137	30	side	side	NOUN
dti-1416	137	31	bar	bar	NOUN
dti-1416	137	32	section	section	NOUN
dti-1416	137	33	tool	tool	NOUN
dti-1416	137	34	.	.	PUNCT
dti-1416	138	1	another	another	DET
dti-1416	138	2	efficient	efficient	ADJ
dti-1416	138	3	way	way	NOUN
dti-1416	138	4	to	to	PART
dti-1416	138	5	navigate	navigate	VERB
dti-1416	138	6	is	be	AUX
dti-1416	138	7	to	to	PART
dti-1416	138	8	select	select	VERB
dti-1416	138	9	the	the	DET
dti-1416	138	10	category	category	NOUN
dti-1416	138	11	link	link	NOUN
dti-1416	138	12	titled	title	VERB
dti-1416	138	13	dosing	dose	VERB
dti-1416	138	14	guidelines	guideline	NOUN
dti-1416	138	15	displayed	display	VERB
dti-1416	138	16	on	on	ADP
dti-1416	138	17	the	the	DET
dti-1416	138	18	home	home	NOUN
dti-1416	138	19	page	page	NOUN
dti-1416	138	20	and	and	CCONJ
dti-1416	138	21	scrolling	scroll	VERB
dti-1416	138	22	to	to	ADP
dti-1416	138	23	the	the	DET
dti-1416	138	24	drug	drug	NOUN
dti-1416	138	25	name	name	NOUN
dti-1416	138	26	such	such	ADJ
dti-1416	138	27	as	as	ADP
dti-1416	138	28	codeine	codeine	NOUN
dti-1416	138	29	,	,	PUNCT
dti-1416	138	30	for	for	ADP
dti-1416	138	31	example	example	NOUN
dti-1416	138	32	.	.	PUNCT
dti-1416	139	1	displayed	display	VERB
dti-1416	139	2	here	here	ADV
dti-1416	139	3	is	be	AUX
dti-1416	139	4	a	a	DET
dti-1416	139	5	side	side	NOUN
dti-1416	139	6	-	-	PUNCT
dti-1416	139	7	by	by	ADP
dti-1416	139	8	-	-	PUNCT
dti-1416	139	9	side	side	NOUN
dti-1416	139	10	selection	selection	NOUN
dti-1416	139	11	of	of	ADP
dti-1416	139	12	the	the	DET
dti-1416	139	13	available	available	NOUN
dti-1416	139	14	vetted	vet	VERB
dti-1416	139	15	pgx	pgx	PROPN
dti-1416	139	16	clinical	clinical	ADJ
dti-1416	139	17	practice	practice	NOUN
dti-1416	139	18	guidelines	guideline	NOUN
dti-1416	139	19	for	for	ADP
dti-1416	139	20	codeine.23	codeine.23	NOUN
dti-1416	139	21	accessing	access	VERB
dti-1416	139	22	the	the	DET
dti-1416	139	23	link	link	NOUN
dti-1416	139	24	in	in	ADP
dti-1416	139	25	the	the	DET
dti-1416	139	26	first	first	ADJ
dti-1416	139	27	column	column	NOUN
dti-1416	139	28	displays	display	VERB
dti-1416	139	29	an	an	DET
dti-1416	139	30	annotation	annotation	NOUN
dti-1416	139	31	of	of	ADP
dti-1416	139	32	the	the	DET
dti-1416	139	33	clinical	clinical	ADJ
dti-1416	139	34	pharmacogenetics	pharmacogenetic	NOUN
dti-1416	139	35	implementation	implementation	NOUN
dti-1416	139	36	consortium	consortium	PROPN
dti-1416	139	37	(	(	PUNCT
dti-1416	139	38	cpic	cpic	NOUN
dti-1416	139	39	)	)	PUNCT
dti-1416	139	40	guidelines	guideline	NOUN
dti-1416	139	41	concerning	concern	VERB
dti-1416	139	42	codeine	codeine	NOUN
dti-1416	139	43	and	and	CCONJ
dti-1416	139	44	cyp2d6	cyp2d6	NOUN
dti-1416	139	45	.	.	PUNCT
dti-1416	140	1	the	the	DET
dti-1416	140	2	cpic	cpic	NOUN
dti-1416	140	3	guidelines	guideline	NOUN
dti-1416	140	4	are	be	AUX
dti-1416	140	5	composed	compose	VERB
dti-1416	140	6	by	by	ADP
dti-1416	140	7	an	an	DET
dti-1416	140	8	international	international	ADJ
dti-1416	140	9	expert	expert	NOUN
dti-1416	140	10	panel	panel	NOUN
dti-1416	140	11	with	with	ADP
dti-1416	140	12	a	a	DET
dti-1416	140	13	mission	mission	NOUN
dti-1416	140	14	to	to	PART
dti-1416	140	15	help	help	VERB
dti-1416	140	16	clinicians	clinician	NOUN
dti-1416	140	17	use	use	VERB
dti-1416	140	18	genetic	genetic	ADJ
dti-1416	140	19	testing	testing	NOUN
dti-1416	140	20	to	to	PART
dti-1416	140	21	inform	inform	VERB
dti-1416	140	22	safe	safe	ADJ
dti-1416	140	23	prescribing	prescribing	NOUN
dti-1416	140	24	(	(	PUNCT
dti-1416	140	25	https://cpicpgx	https://cpicpgx	X
dti-1416	140	26	.	.	NOUN
dti-1416	140	27	org/	org/	NUM
dti-1416	140	28	)	)	PUNCT
dti-1416	140	29	.	.	PUNCT
dti-1416	141	1	the	the	DET
dti-1416	141	2	cpic	cpic	NOUN
dti-1416	141	3	recommends	recommend	VERB
dti-1416	141	4	using	use	VERB
dti-1416	141	5	alternate	alternate	ADJ
dti-1416	141	6	analgesics	analgesic	NOUN
dti-1416	141	7	for	for	ADP
dti-1416	141	8	people	people	NOUN
dti-1416	141	9	categorized	categorize	VERB
dti-1416	141	10	as	as	ADP
dti-1416	141	11	ums	ums	NOUN
dti-1416	141	12	and	and	CCONJ
dti-1416	141	13	pms	pm	NOUN
dti-1416	141	14	.	.	PUNCT
dti-1416	142	1	for	for	ADP
dti-1416	142	2	those	those	PRON
dti-1416	142	3	categorized	categorize	VERB
dti-1416	142	4	as	as	ADP
dti-1416	142	5	nms	nms	NOUN
dti-1416	142	6	(	(	PUNCT
dti-1416	142	7	ims	ims	PROPN
dti-1416	142	8	and	and	CCONJ
dti-1416	142	9	ems	ems	PROPN
dti-1416	142	10	)	)	PUNCT
dti-1416	142	11	,	,	PUNCT
dti-1416	142	12	cpic	cpic	NOUN
dti-1416	142	13	advises	advise	VERB
dti-1416	142	14	following	follow	VERB
dti-1416	142	15	the	the	DET
dti-1416	142	16	fda	fda	PROPN
dti-1416	142	17	labeling	labeling	NOUN
dti-1416	142	18	recommendations	recommendation	NOUN
dti-1416	142	19	which	which	PRON
dti-1416	142	20	contraindicate	contraindicate	VERB
dti-1416	142	21	the	the	DET
dti-1416	142	22	use	use	NOUN
dti-1416	142	23	of	of	ADP
dti-1416	142	24	codeine	codeine	NOUN
dti-1416	142	25	in	in	ADP
dti-1416	142	26	children	child	NOUN
dti-1416	142	27	less	less	ADJ
dti-1416	142	28	than	than	ADP
dti-1416	142	29	18	18	NUM
dti-1416	142	30	years	year	NOUN
dti-1416	142	31	old	old	ADJ
dti-1416	142	32	and	and	CCONJ
dti-1416	142	33	in	in	ADP
dti-1416	142	34	breastfeeding	breastfeed	VERB
dti-1416	142	35	women	woman	NOUN
dti-1416	142	36	.	.	PUNCT
dti-1416	143	1	next	next	ADJ
dti-1416	143	2	,	,	PUNCT
dti-1416	143	3	guidelines	guideline	NOUN
dti-1416	143	4	from	from	ADP
dti-1416	143	5	the	the	DET
dti-1416	143	6	royal	royal	PROPN
dti-1416	143	7	dutch	dutch	PROPN
dti-1416	143	8	association	association	NOUN
dti-1416	143	9	for	for	ADP
dti-1416	143	10	the	the	DET
dti-1416	143	11	advancement	advancement	NOUN
dti-1416	143	12	of	of	ADP
dti-1416	143	13	pharmacy	pharmacy	NOUN
dti-1416	143	14	—	—	PUNCT
dti-1416	143	15	pharmacogenetics	pharmacogenetics	PROPN
dti-1416	143	16	working	working	NOUN
dti-1416	143	17	group	group	NOUN
dti-1416	143	18	(	(	PUNCT
dti-1416	143	19	dpwg	dpwg	PROPN
dti-1416	143	20	)	)	PUNCT
dti-1416	143	21	are	be	AUX
dti-1416	143	22	posted	post	VERB
dti-1416	143	23	for	for	ADP
dti-1416	143	24	comparison	comparison	NOUN
dti-1416	143	25	.	.	PUNCT
dti-1416	144	1	notice	notice	VERB
dti-1416	144	2	that	that	SCONJ
dti-1416	144	3	dpwg	dpwg	PROPN
dti-1416	144	4	recommendations	recommendation	NOUN
dti-1416	144	5	differ	differ	VERB
dti-1416	144	6	from	from	ADP
dti-1416	144	7	cpic	cpic	NOUN
dti-1416	144	8	by	by	ADP
dti-1416	144	9	advising	advise	VERB
dti-1416	144	10	that	that	SCONJ
dti-1416	144	11	ims	ims	PROPN
dti-1416	144	12	avoid	avoid	VERB
dti-1416	144	13	codeine	codeine	NOUN
dti-1416	144	14	use	use	NOUN
dti-1416	144	15	as	as	ADV
dti-1416	144	16	well	well	ADV
dti-1416	144	17	as	as	ADP
dti-1416	144	18	ums	ums	NOUN
dti-1416	144	19	and	and	CCONJ
dti-1416	144	20	pms	pm	NOUN
dti-1416	144	21	.	.	PUNCT
dti-1416	145	1	the	the	DET
dti-1416	145	2	last	last	ADJ
dti-1416	145	3	link	link	NOUN
dti-1416	145	4	leads	lead	VERB
dti-1416	145	5	to	to	ADP
dti-1416	145	6	the	the	DET
dti-1416	145	7	canadian	canadian	ADJ
dti-1416	145	8	pharmacogenomics	pharmacogenomic	NOUN
dti-1416	145	9	network	network	NOUN
dti-1416	145	10	for	for	ADP
dti-1416	145	11	drug	drug	NOUN
dti-1416	145	12	safety	safety	NOUN
dti-1416	145	13	(	(	PUNCT
dti-1416	145	14	cpnds	cpnd	NOUN
dti-1416	145	15	)	)	PUNCT
dti-1416	145	16	guidelines	guideline	NOUN
dti-1416	145	17	that	that	PRON
dti-1416	145	18	match	match	VERB
dti-1416	145	19	cpic	cpic	NOUN
dti-1416	145	20	recommendations	recommendation	NOUN
dti-1416	145	21	on	on	ADP
dti-1416	145	22	codeine	codeine	NOUN
dti-1416	145	23	use	use	NOUN
dti-1416	145	24	and	and	CCONJ
dti-1416	145	25	cyp2d6	cyp2d6	NOUN
dti-1416	145	26	genotype	genotype	PROPN
dti-1416	145	27	.	.	PUNCT
dti-1416	146	1	predicting	predict	VERB
dti-1416	146	2	the	the	DET
dti-1416	146	3	risk	risk	NOUN
dti-1416	146	4	for	for	ADP
dti-1416	146	5	adverse	adverse	ADJ
dti-1416	146	6	drug	drug	NOUN
dti-1416	146	7	reactions	reaction	NOUN
dti-1416	146	8	one	one	NUM
dti-1416	146	9	of	of	ADP
dti-1416	146	10	the	the	DET
dti-1416	146	11	most	most	ADV
dti-1416	146	12	promising	promising	ADJ
dti-1416	146	13	applications	application	NOUN
dti-1416	146	14	of	of	ADP
dti-1416	146	15	pgx	pgx	PROPN
dti-1416	146	16	information	information	NOUN
dti-1416	146	17	is	be	AUX
dti-1416	146	18	the	the	DET
dti-1416	146	19	ability	ability	NOUN
dti-1416	146	20	to	to	PART
dti-1416	146	21	predict	predict	VERB
dti-1416	146	22	an	an	DET
dti-1416	146	23	individual	individual	ADJ
dti-1416	146	24	patient	patient	NOUN
dti-1416	146	25	’s	’s	PART
dti-1416	146	26	risk	risk	NOUN
dti-1416	146	27	for	for	ADP
dti-1416	146	28	developing	develop	VERB
dti-1416	146	29	certain	certain	ADJ
dti-1416	146	30	drug	drug	NOUN
dti-1416	146	31	side	side	NOUN
dti-1416	146	32	effects	effect	NOUN
dti-1416	146	33	.	.	PUNCT
dti-1416	147	1	approximately	approximately	ADV
dti-1416	147	2	15	15	NUM
dti-1416	147	3	%	%	NOUN
dti-1416	147	4	of	of	ADP
dti-1416	147	5	adverse	adverse	ADJ
dti-1416	147	6	drug	drug	NOUN
dti-1416	147	7	reactions	reaction	NOUN
dti-1416	147	8	(	(	PUNCT
dti-1416	147	9	adrs	adr	NOUN
dti-1416	147	10	)	)	PUNCT
dti-1416	147	11	are	be	AUX
dti-1416	147	12	type	type	NOUN
dti-1416	147	13	b	b	NOUN
dti-1416	147	14	or	or	CCONJ
dti-1416	147	15	idiosyncratic	idiosyncratic	ADJ
dti-1416	147	16	reactions	reaction	NOUN
dti-1416	147	17	,	,	PUNCT
dti-1416	147	18	meaning	mean	VERB
dti-1416	147	19	they	they	PRON
dti-1416	147	20	are	be	AUX
dti-1416	147	21	not	not	PART
dti-1416	147	22	related	relate	VERB
dti-1416	147	23	to	to	ADP
dti-1416	147	24	the	the	DET
dti-1416	147	25	expected	expect	VERB
dti-1416	147	26	pharmacology	pharmacology	NOUN
dti-1416	147	27	,	,	PUNCT
dti-1416	147	28	pharmacokinetics	pharmacokinetic	NOUN
dti-1416	147	29	,	,	PUNCT
dti-1416	147	30	or	or	CCONJ
dti-1416	147	31	systemic	systemic	ADJ
dti-1416	147	32	concentration	concentration	NOUN
dti-1416	147	33	of	of	ADP
dti-1416	147	34	a	a	DET
dti-1416	147	35	medication.24	medication.24	NOUN
dti-1416	147	36	often	often	ADV
dti-1416	147	37	these	these	PRON
dti-1416	147	38	are	be	AUX
dti-1416	147	39	immune	immune	NOUN
dti-1416	147	40	-	-	PUNCT
dti-1416	147	41	mediated	mediate	VERB
dti-1416	147	42	,	,	PUNCT
dti-1416	147	43	hypersensitivity	hypersensitivity	NOUN
dti-1416	147	44	reactions	reaction	NOUN
dti-1416	147	45	that	that	SCONJ
dti-1416	147	46	in	in	ADP
dti-1416	147	47	some	some	DET
dti-1416	147	48	cases	case	NOUN
dti-1416	147	49	have	have	AUX
dti-1416	147	50	been	be	AUX
dti-1416	147	51	associated	associate	VERB
dti-1416	147	52	with	with	ADP
dti-1416	147	53	genetic	genetic	ADJ
dti-1416	147	54	risk	risk	NOUN
dti-1416	147	55	factors	factor	NOUN
dti-1416	147	56	.	.	PUNCT
dti-1416	148	1	several	several	ADJ
dti-1416	148	2	strong	strong	ADJ
dti-1416	148	3	associations	association	NOUN
dti-1416	148	4	between	between	ADP
dti-1416	148	5	variants	variant	NOUN
dti-1416	148	6	of	of	ADP
dti-1416	148	7	the	the	DET
dti-1416	148	8	human	human	ADJ
dti-1416	148	9	leukocyte	leukocyte	NOUN
dti-1416	148	10	antigen	antigen	NOUN
dti-1416	148	11	(	(	PUNCT
dti-1416	148	12	hla	hla	NOUN
dti-1416	148	13	)	)	PUNCT
dti-1416	148	14	gene	gene	NOUN
dti-1416	148	15	complex	complex	NOUN
dti-1416	148	16	and	and	CCONJ
dti-1416	148	17	the	the	DET
dti-1416	148	18	occurrence	occurrence	NOUN
dti-1416	148	19	of	of	ADP
dti-1416	148	20	severe	severe	ADJ
dti-1416	148	21	cutaneous	cutaneous	ADJ
dti-1416	148	22	reactions	reaction	NOUN
dti-1416	148	23	have	have	AUX
dti-1416	148	24	been	be	AUX
dti-1416	148	25	established	establish	VERB
dti-1416	148	26	for	for	ADP
dti-1416	148	27	a	a	DET
dti-1416	148	28	range	range	NOUN
dti-1416	148	29	of	of	ADP
dti-1416	148	30	drugs.25	drugs.25	NOUN
dti-1416	148	31	for	for	ADP
dti-1416	148	32	this	this	DET
dti-1416	148	33	reason	reason	NOUN
dti-1416	148	34	,	,	PUNCT
dti-1416	148	35	pharmgkb	pharmgkb	PROPN
dti-1416	148	36	designates	designate	VERB
dti-1416	148	37	the	the	DET
dti-1416	148	38	human	human	ADJ
dti-1416	148	39	leukocyte	leukocyte	NOUN
dti-1416	148	40	antigen	antigen	NOUN
dti-1416	148	41	b	b	X
dti-1416	148	42	(	(	PUNCT
dti-1416	148	43	hla	hla	PROPN
dti-1416	148	44	-	-	PUNCT
dti-1416	148	45	b	b	NOUN
dti-1416	148	46	)	)	PUNCT
dti-1416	148	47	gene	gene	NOUN
dti-1416	148	48	as	as	ADP
dti-1416	148	49	a	a	DET
dti-1416	148	50	vip	vip	NOUN
dti-1416	148	51	and	and	CCONJ
dti-1416	148	52	provides	provide	VERB
dti-1416	148	53	links	link	NOUN
dti-1416	148	54	to	to	ADP
dti-1416	148	55	cpic	cpic	NOUN
dti-1416	148	56	guidelines	guideline	NOUN
dti-1416	148	57	on	on	ADP
dti-1416	148	58	its	its	PRON
dti-1416	148	59	website	website	NOUN
dti-1416	148	60	,	,	PUNCT
dti-1416	148	61	which	which	PRON
dti-1416	148	62	address	address	VERB
dti-1416	148	63	hla	hla	NOUN
dti-1416	148	64	gene	gene	NOUN
dti-1416	148	65	testing	testing	NOUN
dti-1416	148	66	and	and	CCONJ
dti-1416	148	67	safe	safe	ADJ
dti-1416	148	68	use	use	NOUN
dti-1416	148	69	recommendations	recommendation	NOUN
dti-1416	148	70	for	for	ADP
dti-1416	148	71	abacavir	abacavir	NOUN
dti-1416	148	72	,	,	PUNCT
dti-1416	148	73	allopurinol	allopurinol	NOUN
dti-1416	148	74	,	,	PUNCT
dti-1416	148	75	phenytoin	phenytoin	NOUN
dti-1416	148	76	,	,	PUNCT
dti-1416	148	77	oxcarbazepine	oxcarbazepine	ADJ
dti-1416	148	78	,	,	PUNCT
dti-1416	148	79	and	and	CCONJ
dti-1416	148	80	carbamazepine.26	carbamazepine.26	VERB
dti-1416	148	81	the	the	DET
dti-1416	148	82	hla	hla	PROPN
dti-1416	148	83	-	-	PUNCT
dti-1416	148	84	b	b	NOUN
dti-1416	148	85	gene	gene	NOUN
dti-1416	148	86	is	be	AUX
dti-1416	148	87	part	part	NOUN
dti-1416	148	88	of	of	ADP
dti-1416	148	89	a	a	DET
dti-1416	148	90	complex	complex	NOUN
dti-1416	148	91	of	of	ADP
dti-1416	148	92	genes	gene	NOUN
dti-1416	148	93	located	locate	VERB
dti-1416	148	94	on	on	ADP
dti-1416	148	95	chromosome	chromosome	NOUN
dti-1416	148	96	6	6	NUM
dti-1416	148	97	that	that	PRON
dti-1416	148	98	encode	encode	ADJ
dti-1416	148	99	for	for	ADP
dti-1416	148	100	cell	cell	NOUN
dti-1416	148	101	surface	surface	NOUN
dti-1416	148	102	proteins	protein	NOUN
dti-1416	148	103	involved	involve	VERB
dti-1416	148	104	in	in	ADP
dti-1416	148	105	presenting	present	VERB
dti-1416	148	106	antigens	antigen	NOUN
dti-1416	148	107	to	to	ADP
dti-1416	148	108	the	the	DET
dti-1416	148	109	immune	immune	ADJ
dti-1416	148	110	system	system	NOUN
dti-1416	148	111	.	.	PUNCT
dti-1416	149	1	specific	specific	ADJ
dti-1416	149	2	allelic	allelic	ADJ
dti-1416	149	3	variants	variant	NOUN
dti-1416	149	4	of	of	ADP
dti-1416	149	5	hla	hla	PROPN
dti-1416	149	6	-	-	PUNCT
dti-1416	149	7	b	b	NOUN
dti-1416	149	8	have	have	AUX
dti-1416	149	9	been	be	AUX
dti-1416	149	10	associated	associate	VERB
dti-1416	149	11	with	with	ADP
dti-1416	149	12	the	the	DET
dti-1416	149	13	development	development	NOUN
dti-1416	149	14	of	of	ADP
dti-1416	149	15	table	table	NOUN
dti-1416	149	16	1	1	NUM
dti-1416	149	17	.	.	X
dti-1416	149	18	cytochrome	cytochrome	PROPN
dti-1416	149	19	p450	p450	PROPN
dti-1416	149	20	cyp2d6	cyp2d6	NOUN
dti-1416	149	21	allelic	allelic	ADJ
dti-1416	149	22	variants	variant	NOUN
dti-1416	149	23	and	and	CCONJ
dti-1416	149	24	enzyme	enzyme	NOUN
dti-1416	149	25	activity	activity	NOUN
dti-1416	149	26	.	.	PUNCT
dti-1416	150	1	phenotype	phenotype	NOUN
dti-1416	150	2	:	:	PUNCT
dti-1416	150	3	cyp2d6	cyp2d6	NOUN
dti-1416	150	4	enzyme	enzyme	NOUN
dti-1416	150	5	activity	activity	NOUN
dti-1416	150	6	level	level	NOUN
dti-1416	150	7	cyp2d6	cyp2d6	NOUN
dti-1416	150	8	gene	gene	NOUN
dti-1416	150	9	variant	variant	NOUN
dti-1416	150	10	(	(	PUNCT
dti-1416	150	11	cyp2d6*x	cyp2d6*x	PROPN
dti-1416	150	12	)	)	PUNCT
dti-1416	150	13	no	no	DET
dti-1416	150	14	function	function	NOUN
dti-1416	150	15	(	(	PUNCT
dti-1416	150	16	null	null	NOUN
dti-1416	150	17	)	)	PUNCT
dti-1416	150	18	alleles	allele	NOUN
dti-1416	150	19	*	*	PUNCT
dti-1416	150	20	3	3	NUM
dti-1416	150	21	*	*	SYM
dti-1416	150	22	4	4	NUM
dti-1416	150	23	*	*	SYM
dti-1416	150	24	5	5	NUM
dti-1416	150	25	*	*	SYM
dti-1416	150	26	6	6	NUM
dti-1416	150	27	*	*	SYM
dti-1416	150	28	7	7	NUM
dti-1416	150	29	*	*	SYM
dti-1416	150	30	8	8	NUM
dti-1416	150	31	*	*	SYM
dti-1416	150	32	11	11	NUM
dti-1416	150	33	*	*	SYM
dti-1416	150	34	12	12	NUM
dti-1416	150	35	*	*	SYM
dti-1416	150	36	13	13	NUM
dti-1416	150	37	*	*	SYM
dti-1416	150	38	15	15	NUM
dti-1416	150	39	*	*	SYM
dti-1416	150	40	18	18	NUM
dti-1416	150	41	*	*	SYM
dti-1416	150	42	19	19	NUM
dti-1416	150	43	*	*	SYM
dti-1416	150	44	20	20	NUM
dti-1416	150	45	*	*	SYM
dti-1416	150	46	21	21	NUM
dti-1416	150	47	*	*	SYM
dti-1416	150	48	31	31	NUM
dti-1416	150	49	*	*	SYM
dti-1416	150	50	36	36	NUM
dti-1416	150	51	*	*	SYM
dti-1416	150	52	38	38	NUM
dti-1416	150	53	*	*	SYM
dti-1416	150	54	40	40	NUM
dti-1416	150	55	*	*	SYM
dti-1416	150	56	42	42	NUM
dti-1416	150	57	*	*	SYM
dti-1416	150	58	44	44	NUM
dti-1416	150	59	*	*	SYM
dti-1416	150	60	47	47	NUM
dti-1416	150	61	*	*	SYM
dti-1416	150	62	51	51	NUM
dti-1416	150	63	*	*	PUNCT
dti-1416	150	64	56	56	NUM
dti-1416	150	65	*	*	SYM
dti-1416	150	66	57	57	NUM
dti-1416	150	67	*	*	SYM
dti-1416	150	68	60	60	NUM
dti-1416	150	69	*	*	SYM
dti-1416	150	70	62	62	NUM
dti-1416	150	71	*	*	SYM
dti-1416	150	72	68	68	NUM
dti-1416	150	73	*	*	SYM
dti-1416	150	74	69	69	NUM
dti-1416	150	75	*	*	PUNCT
dti-1416	150	76	92	92	NUM
dti-1416	150	77	*	*	SYM
dti-1416	150	78	96	96	NUM
dti-1416	150	79	*	*	SYM
dti-1416	150	80	99	99	NUM
dti-1416	150	81	*	*	SYM
dti-1416	150	82	100	100	NUM
dti-1416	150	83	*	*	SYM
dti-1416	150	84	101	101	NUM
dti-1416	150	85	*	*	SYM
dti-1416	150	86	114	114	NUM
dti-1416	150	87	decreased	decrease	VERB
dti-1416	150	88	function	function	NOUN
dti-1416	150	89	alleles	allele	NOUN
dti-1416	150	90	*	*	PUNCT
dti-1416	150	91	9	9	NUM
dti-1416	150	92	*	*	SYM
dti-1416	150	93	10	10	NUM
dti-1416	150	94	*	*	SYM
dti-1416	150	95	14	14	NUM
dti-1416	150	96	*	*	SYM
dti-1416	150	97	17	17	NUM
dti-1416	150	98	*	*	SYM
dti-1416	150	99	29	29	NUM
dti-1416	150	100	*	*	SYM
dti-1416	150	101	41	41	NUM
dti-1416	150	102	*	*	SYM
dti-1416	150	103	49	49	NUM
dti-1416	150	104	*	*	SYM
dti-1416	150	105	50	50	NUM
dti-1416	150	106	*	*	SYM
dti-1416	150	107	54	54	NUM
dti-1416	150	108	*	*	SYM
dti-1416	150	109	55	55	NUM
dti-1416	150	110	*	*	SYM
dti-1416	150	111	59	59	NUM
dti-1416	150	112	*	*	SYM
dti-1416	150	113	72	72	NUM
dti-1416	150	114	*	*	SYM
dti-1416	150	115	84	84	NUM
dti-1416	150	116	normal	normal	ADJ
dti-1416	150	117	function	function	NOUN
dti-1416	150	118	alleles	allele	NOUN
dti-1416	150	119	*	*	NOUN
dti-1416	150	120	1	1	NUM
dti-1416	150	121	(	(	PUNCT
dti-1416	150	122	wild	wild	ADJ
dti-1416	150	123	type	type	NOUN
dti-1416	150	124	)	)	PUNCT
dti-1416	150	125	*	*	PUNCT
dti-1416	150	126	2	2	NUM
dti-1416	150	127	*	*	SYM
dti-1416	150	128	27	27	NUM
dti-1416	150	129	*	*	SYM
dti-1416	150	130	33	33	NUM
dti-1416	150	131	*	*	SYM
dti-1416	150	132	34	34	NUM
dti-1416	150	133	*	*	SYM
dti-1416	150	134	35	35	NUM
dti-1416	150	135	*	*	SYM
dti-1416	150	136	39	39	NUM
dti-1416	150	137	*	*	SYM
dti-1416	150	138	45	45	NUM
dti-1416	150	139	*	*	SYM
dti-1416	150	140	46	46	NUM
dti-1416	150	141	*	*	SYM
dti-1416	150	142	48	48	NUM
dti-1416	150	143	*	*	SYM
dti-1416	150	144	53	53	NUM
dti-1416	150	145	increased	increase	VERB
dti-1416	150	146	function	function	NOUN
dti-1416	150	147	alleles	allele	NOUN
dti-1416	150	148	copy	copy	VERB
dti-1416	150	149	number	number	NOUN
dti-1416	150	150	variants	variant	NOUN
dti-1416	150	151	*	*	PUNCT
dti-1416	150	152	1	1	NUM
dti-1416	150	153	×	×	NOUN
dti-1416	150	154	n	n	PRON
dti-1416	150	155	*	*	SYM
dti-1416	150	156	2	2	NUM
dti-1416	150	157	×	×	NOUN
dti-1416	150	158	n	n	PROPN
dti-1416	150	159	*	*	PROPN
dti-1416	150	160	35	35	NUM
dti-1416	150	161	×	×	NOUN
dti-1416	150	162	2	2	NUM
dti-1416	150	163	uncertain	uncertain	ADJ
dti-1416	150	164	/	/	SYM
dti-1416	150	165	unknown	unknown	ADJ
dti-1416	150	166	function	function	NOUN
dti-1416	150	167	alleles	allele	VERB
dti-1416	150	168	*	*	PUNCT
dti-1416	150	169	22	22	NUM
dti-1416	150	170	*	*	SYM
dti-1416	150	171	23	23	NUM
dti-1416	150	172	*	*	SYM
dti-1416	150	173	24	24	NUM
dti-1416	150	174	*	*	SYM
dti-1416	150	175	25	25	NUM
dti-1416	150	176	*	*	SYM
dti-1416	150	177	26	26	NUM
dti-1416	150	178	*	*	SYM
dti-1416	150	179	28	28	NUM
dti-1416	150	180	*	*	SYM
dti-1416	150	181	30	30	NUM
dti-1416	150	182	*	*	SYM
dti-1416	150	183	37	37	NUM
dti-1416	150	184	*	*	SYM
dti-1416	150	185	43	43	NUM
dti-1416	150	186	*	*	SYM
dti-1416	150	187	52	52	NUM
dti-1416	150	188	*	*	SYM
dti-1416	150	189	58	58	NUM
dti-1416	150	190	*	*	SYM
dti-1416	150	191	61	61	NUM
dti-1416	150	192	*	*	SYM
dti-1416	150	193	63	63	NUM
dti-1416	150	194	*	*	SYM
dti-1416	150	195	64	64	NUM
dti-1416	150	196	*	*	SYM
dti-1416	150	197	65	65	NUM
dti-1416	150	198	*	*	SYM
dti-1416	150	199	70	70	NUM
dti-1416	150	200	*	*	SYM
dti-1416	150	201	71	71	NUM
dti-1416	150	202	*	*	SYM
dti-1416	150	203	73	73	NUM
dti-1416	150	204	*	*	SYM
dti-1416	150	205	74	74	NUM
dti-1416	150	206	*	*	SYM
dti-1416	150	207	75	75	NUM
dti-1416	150	208	*	*	SYM
dti-1416	150	209	81	81	NUM
dti-1416	150	210	*	*	SYM
dti-1416	150	211	82	82	NUM
dti-1416	150	212	*	*	NUM
dti-1416	150	213	83	83	NUM
dti-1416	150	214	*	*	SYM
dti-1416	150	215	85	85	NUM
dti-1416	150	216	*	*	SYM
dti-1416	150	217	86	86	NUM
dti-1416	150	218	*	*	SYM
dti-1416	150	219	87	87	NUM
dti-1416	150	220	*	*	SYM
dti-1416	150	221	88	88	NUM
dti-1416	150	222	*	*	SYM
dti-1416	150	223	89	89	NUM
dti-1416	150	224	*	*	SYM
dti-1416	150	225	90	90	NUM
dti-1416	150	226	*	*	NUM
dti-1416	150	227	91	91	NUM
dti-1416	150	228	*	*	SYM
dti-1416	150	229	93	93	NUM
dti-1416	150	230	*	*	SYM
dti-1416	150	231	94	94	NUM
dti-1416	150	232	*	*	SYM
dti-1416	150	233	95	95	NUM
dti-1416	151	1	*	*	NUM
dti-1416	151	2	97	97	NUM
dti-1416	152	1	*	*	SYM
dti-1416	152	2	98	98	NUM
dti-1416	153	1	*	*	SYM
dti-1416	153	2	102	102	NUM
dti-1416	154	1	*	*	SYM
dti-1416	154	2	103	103	NUM
dti-1416	154	3	*	*	SYM
dti-1416	154	4	104	104	NUM
dti-1416	155	1	*	*	SYM
dti-1416	155	2	105	105	NUM
dti-1416	155	3	*	*	SYM
dti-1416	155	4	106	106	NUM
dti-1416	155	5	*	*	SYM
dti-1416	155	6	107	107	NUM
dti-1416	155	7	*	*	SYM
dti-1416	155	8	108	108	NUM
dti-1416	155	9	*	*	SYM
dti-1416	155	10	109	109	NUM
dti-1416	155	11	*	*	SYM
dti-1416	155	12	110	110	NUM
dti-1416	155	13	*	*	SYM
dti-1416	155	14	111	111	NUM
dti-1416	155	15	*	*	SYM
dti-1416	155	16	112	112	NUM
dti-1416	155	17	*	*	SYM
dti-1416	155	18	113	113	NUM
dti-1416	155	19	source	source	NOUN
dti-1416	155	20	:	:	PUNCT
dti-1416	155	21	adapted	adapt	VERB
dti-1416	155	22	from	from	ADP
dti-1416	155	23	pharmacogene	pharmacogene	NOUN
dti-1416	155	24	variation	variation	NOUN
dti-1416	155	25	consortium	consortium	NOUN
dti-1416	155	26	(	(	PUNCT
dti-1416	155	27	pharmvar).21	pharmvar).21	PROPN
dti-1416	155	28	https://cpicpgx.org/	https://cpicpgx.org/	PRON
dti-1416	155	29	https://cpicpgx.org/	https://cpicpgx.org/	PRON
dti-1416	155	30	6	6	NUM
dti-1416	155	31	drug	drug	NOUN
dti-1416	155	32	target	target	NOUN
dti-1416	155	33	insights	insight	NOUN
dti-1416	155	34	severe	severe	ADJ
dti-1416	155	35	cutaneous	cutaneous	ADJ
dti-1416	155	36	adrs	adr	NOUN
dti-1416	155	37	following	follow	VERB
dti-1416	155	38	exposure	exposure	NOUN
dti-1416	155	39	to	to	ADP
dti-1416	155	40	carbamazepine	carbamazepine	NOUN
dti-1416	155	41	typically	typically	ADV
dti-1416	155	42	occurring	occur	VERB
dti-1416	155	43	early	early	ADV
dti-1416	155	44	in	in	ADP
dti-1416	155	45	therapy	therapy	NOUN
dti-1416	155	46	.	.	PUNCT
dti-1416	156	1	known	know	VERB
dti-1416	156	2	as	as	ADP
dti-1416	156	3	stevens	stevens	PROPN
dti-1416	156	4	-	-	PUNCT
dti-1416	156	5	johnson	johnson	PROPN
dti-1416	156	6	syndrome	syndrome	PROPN
dti-1416	156	7	(	(	PUNCT
dti-1416	156	8	sjs	sjs	PROPN
dti-1416	156	9	)	)	PUNCT
dti-1416	156	10	and	and	CCONJ
dti-1416	156	11	toxic	toxic	ADJ
dti-1416	156	12	epidermal	epidermal	ADJ
dti-1416	156	13	necrolysis	necrolysis	NOUN
dti-1416	156	14	(	(	PUNCT
dti-1416	156	15	ten	ten	NUM
dti-1416	156	16	)	)	PUNCT
dti-1416	156	17	,	,	PUNCT
dti-1416	156	18	these	these	DET
dti-1416	156	19	maladies	malady	NOUN
dti-1416	156	20	can	can	AUX
dti-1416	156	21	result	result	VERB
dti-1416	156	22	in	in	ADP
dti-1416	156	23	blistering	blister	VERB
dti-1416	156	24	and	and	CCONJ
dti-1416	156	25	sloughing	sloughing	NOUN
dti-1416	156	26	of	of	ADP
dti-1416	156	27	the	the	DET
dti-1416	156	28	skin	skin	NOUN
dti-1416	156	29	and	and	CCONJ
dti-1416	156	30	mucous	mucous	ADJ
dti-1416	156	31	membranes	membrane	NOUN
dti-1416	156	32	that	that	PRON
dti-1416	156	33	can	can	AUX
dti-1416	156	34	proceed	proceed	VERB
dti-1416	156	35	to	to	PART
dti-1416	156	36	liver	liver	NOUN
dti-1416	156	37	and	and	CCONJ
dti-1416	156	38	other	other	ADJ
dti-1416	156	39	organ	organ	NOUN
dti-1416	156	40	failure.27	failure.27	PROPN
dti-1416	156	41	stevens	stevens	PROPN
dti-1416	156	42	-	-	PUNCT
dti-1416	156	43	johnson	johnson	PROPN
dti-1416	156	44	syndrome	syndrome	NOUN
dti-1416	156	45	and	and	CCONJ
dti-1416	156	46	ten	ten	NUM
dti-1416	156	47	are	be	AUX
dti-1416	156	48	really	really	ADV
dti-1416	156	49	a	a	DET
dti-1416	156	50	continuum	continuum	NOUN
dti-1416	156	51	of	of	ADP
dti-1416	156	52	severity	severity	NOUN
dti-1416	156	53	of	of	ADP
dti-1416	156	54	the	the	DET
dti-1416	156	55	same	same	ADJ
dti-1416	156	56	adverse	adverse	ADJ
dti-1416	156	57	reaction	reaction	NOUN
dti-1416	156	58	.	.	PUNCT
dti-1416	157	1	stevensjohnson	stevensjohnson	PROPN
dti-1416	157	2	syndrome	syndrome	PROPN
dti-1416	157	3	is	be	AUX
dti-1416	157	4	fatal	fatal	ADJ
dti-1416	157	5	in	in	ADP
dti-1416	157	6	10	10	NUM
dti-1416	157	7	%	%	NOUN
dti-1416	157	8	of	of	ADP
dti-1416	157	9	patients	patient	NOUN
dti-1416	157	10	,	,	PUNCT
dti-1416	157	11	whereas	whereas	SCONJ
dti-1416	157	12	50	50	NUM
dti-1416	157	13	%	%	NOUN
dti-1416	157	14	of	of	ADP
dti-1416	157	15	those	those	PRON
dti-1416	157	16	who	who	PRON
dti-1416	157	17	progress	progress	VERB
dti-1416	157	18	to	to	ADP
dti-1416	157	19	ten	ten	NUM
dti-1416	157	20	die	die	VERB
dti-1416	157	21	.	.	PUNCT
dti-1416	158	1	possessing	possess	VERB
dti-1416	158	2	1	1	NUM
dti-1416	158	3	copy	copy	NOUN
dti-1416	158	4	of	of	ADP
dti-1416	158	5	the	the	DET
dti-1416	158	6	hla	hla	PROPN
dti-1416	158	7	-	-	PUNCT
dti-1416	158	8	b*1502	b*1502	VERB
dti-1416	158	9	allele	allele	PROPN
dti-1416	158	10	places	place	VERB
dti-1416	158	11	a	a	DET
dti-1416	158	12	person	person	NOUN
dti-1416	158	13	receiving	receive	VERB
dti-1416	158	14	carbamazepine	carbamazepine	NOUN
dti-1416	158	15	at	at	ADP
dti-1416	158	16	a	a	DET
dti-1416	158	17	greater	great	ADJ
dti-1416	158	18	risk	risk	NOUN
dti-1416	158	19	for	for	ADP
dti-1416	158	20	experiencing	experience	VERB
dti-1416	158	21	these	these	DET
dti-1416	158	22	rare	rare	ADJ
dti-1416	158	23	but	but	CCONJ
dti-1416	158	24	sometimes	sometimes	ADV
dti-1416	158	25	fatal	fatal	ADJ
dti-1416	158	26	delayed	delay	VERB
dti-1416	158	27	hypersensitivity	hypersensitivity	NOUN
dti-1416	158	28	reactions	reaction	NOUN
dti-1416	158	29	.	.	PUNCT
dti-1416	159	1	for	for	ADP
dti-1416	159	2	this	this	DET
dti-1416	159	3	reason	reason	NOUN
dti-1416	159	4	,	,	PUNCT
dti-1416	159	5	the	the	DET
dti-1416	159	6	fda	fda	PROPN
dti-1416	159	7	mandates	mandate	NOUN
dti-1416	159	8	as	as	ADP
dti-1416	159	9	a	a	DET
dti-1416	159	10	boxed	boxed	ADJ
dti-1416	159	11	warning	warning	NOUN
dti-1416	159	12	targeted	target	VERB
dti-1416	159	13	genetic	genetic	ADJ
dti-1416	159	14	testing	testing	NOUN
dti-1416	159	15	for	for	ADP
dti-1416	159	16	the	the	DET
dti-1416	159	17	hla	hla	PROPN
dti-1416	159	18	-	-	PUNCT
dti-1416	159	19	b*1502	b*1502	PROPN
dti-1416	159	20	allele	allele	NOUN
dti-1416	159	21	before	before	ADP
dti-1416	159	22	initiation	initiation	NOUN
dti-1416	159	23	of	of	ADP
dti-1416	159	24	carbamazepine	carbamazepine	NOUN
dti-1416	159	25	in	in	ADP
dti-1416	159	26	ethnic	ethnic	ADJ
dti-1416	159	27	groups	group	NOUN
dti-1416	159	28	more	more	ADV
dti-1416	159	29	likely	likely	ADJ
dti-1416	159	30	to	to	PART
dti-1416	159	31	possess	possess	VERB
dti-1416	159	32	this	this	DET
dti-1416	159	33	allelic	allelic	ADJ
dti-1416	159	34	variant	variant	NOUN
dti-1416	159	35	and	and	CCONJ
dti-1416	159	36	to	to	PART
dti-1416	159	37	avoid	avoid	VERB
dti-1416	159	38	use	use	NOUN
dti-1416	159	39	in	in	ADP
dti-1416	159	40	carriers	carrier	NOUN
dti-1416	159	41	.	.	PUNCT
dti-1416	160	1	these	these	DET
dti-1416	160	2	groups	group	NOUN
dti-1416	160	3	include	include	VERB
dti-1416	160	4	people	people	NOUN
dti-1416	160	5	of	of	ADP
dti-1416	160	6	han	han	PROPN
dti-1416	160	7	chinese	chinese	PROPN
dti-1416	160	8	,	,	PUNCT
dti-1416	160	9	thai	thai	PROPN
dti-1416	160	10	,	,	PUNCT
dti-1416	160	11	malaysian	malaysian	ADJ
dti-1416	160	12	,	,	PUNCT
dti-1416	160	13	indonesian	indonesian	ADJ
dti-1416	160	14	,	,	PUNCT
dti-1416	160	15	filipino	filipino	PROPN
dti-1416	160	16	,	,	PUNCT
dti-1416	160	17	and	and	CCONJ
dti-1416	160	18	south	south	ADJ
dti-1416	160	19	indian	indian	ADJ
dti-1416	160	20	ethnicity	ethnicity	NOUN
dti-1416	160	21	who	who	PRON
dti-1416	160	22	have	have	VERB
dti-1416	160	23	as	as	ADV
dti-1416	160	24	much	much	ADJ
dti-1416	160	25	as	as	ADP
dti-1416	160	26	10	10	NUM
dti-1416	160	27	times	time	NOUN
dti-1416	160	28	the	the	DET
dti-1416	160	29	risk	risk	NOUN
dti-1416	160	30	for	for	ADP
dti-1416	160	31	experiencing	experience	VERB
dti-1416	160	32	hypersensitivity	hypersensitivity	NOUN
dti-1416	160	33	reactions	reaction	NOUN
dti-1416	160	34	than	than	SCONJ
dti-1416	160	35	do	do	VERB
dti-1416	160	36	mainly	mainly	ADV
dti-1416	160	37	caucasian	caucasian	ADJ
dti-1416	160	38	populations	population	NOUN
dti-1416	160	39	.	.	PUNCT
dti-1416	161	1	a	a	DET
dti-1416	161	2	review	review	NOUN
dti-1416	161	3	of	of	ADP
dti-1416	161	4	the	the	DET
dti-1416	161	5	fda	fda	PROPN
dti-1416	161	6	table	table	NOUN
dti-1416	161	7	of	of	ADP
dti-1416	161	8	pharmacogenomic	pharmacogenomic	ADJ
dti-1416	161	9	biomarkers	biomarker	NOUN
dti-1416	161	10	in	in	ADP
dti-1416	161	11	drug	drug	NOUN
dti-1416	161	12	labeling	labeling	NOUN
dti-1416	161	13	identifies	identify	VERB
dti-1416	161	14	the	the	DET
dti-1416	161	15	location	location	NOUN
dti-1416	161	16	within	within	ADP
dti-1416	161	17	the	the	DET
dti-1416	161	18	drug	drug	NOUN
dti-1416	161	19	labeling	labeling	NOUN
dti-1416	161	20	of	of	ADP
dti-1416	161	21	any	any	DET
dti-1416	161	22	recommendation	recommendation	NOUN
dti-1416	161	23	regarding	regard	VERB
dti-1416	161	24	genetic	genetic	ADJ
dti-1416	161	25	testing.28	testing.28	NOUN
dti-1416	161	26	notice	notice	NOUN
dti-1416	161	27	for	for	ADP
dti-1416	161	28	carbamazepine	carbamazepine	NOUN
dti-1416	161	29	that	that	PRON
dti-1416	161	30	the	the	DET
dti-1416	161	31	fda	fda	PROPN
dti-1416	161	32	also	also	ADV
dti-1416	161	33	suggests	suggest	VERB
dti-1416	161	34	but	but	CCONJ
dti-1416	161	35	does	do	AUX
dti-1416	161	36	not	not	PART
dti-1416	161	37	require	require	VERB
dti-1416	161	38	testing	testing	NOUN
dti-1416	161	39	for	for	ADP
dti-1416	161	40	another	another	DET
dti-1416	161	41	hla	hla	NOUN
dti-1416	161	42	complex	complex	ADJ
dti-1416	161	43	gene	gene	NOUN
dti-1416	161	44	variant	variant	NOUN
dti-1416	161	45	,	,	PUNCT
dti-1416	161	46	the	the	DET
dti-1416	161	47	hla	hla	PROPN
dti-1416	161	48	-	-	PUNCT
dti-1416	161	49	a*3101	a*3101	PROPN
dti-1416	161	50	allele	allele	NOUN
dti-1416	161	51	,	,	PUNCT
dti-1416	161	52	which	which	PRON
dti-1416	161	53	is	be	AUX
dti-1416	161	54	associated	associate	VERB
dti-1416	161	55	with	with	ADP
dti-1416	161	56	an	an	DET
dti-1416	161	57	increased	increase	VERB
dti-1416	161	58	risk	risk	NOUN
dti-1416	161	59	of	of	ADP
dti-1416	161	60	drug	drug	NOUN
dti-1416	161	61	reaction	reaction	NOUN
dti-1416	161	62	with	with	ADP
dti-1416	161	63	eosinophilia	eosinophilia	PROPN
dti-1416	161	64	and	and	CCONJ
dti-1416	161	65	systemic	systemic	ADJ
dti-1416	161	66	symptoms	symptom	NOUN
dti-1416	161	67	(	(	PUNCT
dti-1416	161	68	dress	dress	NOUN
dti-1416	161	69	)	)	PUNCT
dti-1416	161	70	and	and	CCONJ
dti-1416	161	71	maculopapular	maculopapular	ADJ
dti-1416	161	72	exanthema	exanthema	NOUN
dti-1416	161	73	(	(	PUNCT
dti-1416	161	74	mpe	mpe	NOUN
dti-1416	161	75	)	)	PUNCT
dti-1416	161	76	as	as	ADV
dti-1416	161	77	well	well	ADV
dti-1416	161	78	as	as	ADP
dti-1416	161	79	sjs	sjs	PROPN
dti-1416	161	80	/	/	SYM
dti-1416	161	81	ten	ten	NUM
dti-1416	161	82	.	.	PUNCT
dti-1416	162	1	this	this	PRON
dti-1416	162	2	differs	differ	VERB
dti-1416	162	3	from	from	ADP
dti-1416	162	4	cpic	cpic	NOUN
dti-1416	162	5	guidelines	guideline	NOUN
dti-1416	162	6	for	for	ADP
dti-1416	162	7	carbamazepine	carbamazepine	NOUN
dti-1416	162	8	and	and	CCONJ
dti-1416	162	9	hla	hla	NOUN
dti-1416	162	10	-	-	PUNCT
dti-1416	162	11	a	a	NOUN
dti-1416	162	12	and	and	CCONJ
dti-1416	162	13	hla	hla	PROPN
dti-1416	162	14	-	-	PUNCT
dti-1416	162	15	b	b	NOUN
dti-1416	162	16	gene	gene	NOUN
dti-1416	162	17	variants	variant	NOUN
dti-1416	162	18	,	,	PUNCT
dti-1416	162	19	which	which	PRON
dti-1416	162	20	recommend	recommend	VERB
dti-1416	162	21	that	that	SCONJ
dti-1416	162	22	testing	testing	NOUN
dti-1416	162	23	for	for	ADP
dti-1416	162	24	both	both	CCONJ
dti-1416	162	25	hlab*1502	hlab*1502	PROPN
dti-1416	162	26	and	and	CCONJ
dti-1416	162	27	hla	hla	PROPN
dti-1416	162	28	-	-	PUNCT
dti-1416	162	29	a*1301	a*1301	PROPN
dti-1416	162	30	be	be	AUX
dti-1416	162	31	conducted	conduct	VERB
dti-1416	162	32	for	for	ADP
dti-1416	162	33	all	all	DET
dti-1416	162	34	carbamazepinenaïve	carbamazepinenaïve	NOUN
dti-1416	162	35	patients	patient	NOUN
dti-1416	162	36	in	in	ADP
dti-1416	162	37	high	high	ADJ
dti-1416	162	38	-	-	PUNCT
dti-1416	162	39	risk	risk	NOUN
dti-1416	162	40	ethnic	ethnic	ADJ
dti-1416	162	41	groups.29	groups.29	NOUN
dti-1416	162	42	for	for	ADP
dti-1416	162	43	clearly	clearly	ADV
dti-1416	162	44	actionable	actionable	ADJ
dti-1416	162	45	and	and	CCONJ
dti-1416	162	46	fda	fda	PROPN
dti-1416	162	47	required	require	VERB
dti-1416	162	48	genetic	genetic	ADJ
dti-1416	162	49	testing	testing	NOUN
dti-1416	162	50	such	such	ADJ
dti-1416	162	51	as	as	ADP
dti-1416	162	52	for	for	ADP
dti-1416	162	53	newstarts	newstart	NOUN
dti-1416	162	54	on	on	ADP
dti-1416	162	55	carbamazepine	carbamazepine	NOUN
dti-1416	162	56	in	in	ADP
dti-1416	162	57	specific	specific	ADJ
dti-1416	162	58	ethnic	ethnic	ADJ
dti-1416	162	59	populations	population	NOUN
dti-1416	162	60	,	,	PUNCT
dti-1416	162	61	pharmacists	pharmacist	NOUN
dti-1416	162	62	can	can	AUX
dti-1416	162	63	play	play	VERB
dti-1416	162	64	an	an	DET
dti-1416	162	65	important	important	ADJ
dti-1416	162	66	role	role	NOUN
dti-1416	162	67	within	within	ADP
dti-1416	162	68	their	their	PRON
dti-1416	162	69	practice	practice	NOUN
dti-1416	162	70	institutions	institution	NOUN
dti-1416	162	71	by	by	ADP
dti-1416	162	72	inquiring	inquire	VERB
dti-1416	162	73	and	and	CCONJ
dti-1416	162	74	conducting	conduct	VERB
dti-1416	162	75	reviews	review	NOUN
dti-1416	162	76	to	to	PART
dti-1416	162	77	determine	determine	VERB
dti-1416	162	78	whether	whether	SCONJ
dti-1416	162	79	appropriate	appropriate	ADJ
dti-1416	162	80	genetic	genetic	ADJ
dti-1416	162	81	testing	testing	NOUN
dti-1416	162	82	is	be	AUX
dti-1416	162	83	being	be	AUX
dti-1416	162	84	done	do	VERB
dti-1416	162	85	.	.	PUNCT
dti-1416	163	1	genetic	genetic	ADJ
dti-1416	163	2	sequencing	sequence	VERB
dti-1416	163	3	the	the	DET
dti-1416	163	4	increasing	increase	VERB
dti-1416	163	5	accessibility	accessibility	NOUN
dti-1416	163	6	and	and	CCONJ
dti-1416	163	7	affordability	affordability	NOUN
dti-1416	163	8	of	of	ADP
dti-1416	163	9	genetic	genetic	ADJ
dti-1416	163	10	testing	testing	NOUN
dti-1416	163	11	is	be	AUX
dti-1416	163	12	driving	drive	VERB
dti-1416	163	13	the	the	DET
dti-1416	163	14	translation	translation	NOUN
dti-1416	163	15	of	of	ADP
dti-1416	163	16	genomic	genomic	ADJ
dti-1416	163	17	medicine	medicine	NOUN
dti-1416	163	18	into	into	ADP
dti-1416	163	19	clinical	clinical	ADJ
dti-1416	163	20	practice	practice	NOUN
dti-1416	163	21	.	.	PUNCT
dti-1416	164	1	improvements	improvement	NOUN
dti-1416	164	2	in	in	ADP
dti-1416	164	3	dna	dna	NOUN
dti-1416	164	4	sequencing	sequencing	NOUN
dti-1416	164	5	technologies	technology	NOUN
dti-1416	164	6	have	have	AUX
dti-1416	164	7	dramatically	dramatically	ADV
dti-1416	164	8	reduced	reduce	VERB
dti-1416	164	9	both	both	CCONJ
dti-1416	164	10	the	the	DET
dti-1416	164	11	cost	cost	NOUN
dti-1416	164	12	and	and	CCONJ
dti-1416	164	13	the	the	DET
dti-1416	164	14	time	time	NOUN
dti-1416	164	15	it	it	PRON
dti-1416	164	16	takes	take	VERB
dti-1416	164	17	to	to	PART
dti-1416	164	18	accomplish	accomplish	VERB
dti-1416	164	19	whole	whole	ADJ
dti-1416	164	20	genome	genome	NOUN
dti-1416	164	21	sequencing	sequence	VERB
dti-1416	164	22	(	(	PUNCT
dti-1416	164	23	wgs	wgs	NOUN
dti-1416	164	24	)	)	PUNCT
dti-1416	164	25	and	and	CCONJ
dti-1416	164	26	whole	whole	ADJ
dti-1416	164	27	exome	exome	NOUN
dti-1416	164	28	sequencing	sequence	VERB
dti-1416	164	29	(	(	PUNCT
dti-1416	164	30	wes	wes	PROPN
dti-1416	164	31	)	)	PUNCT
dti-1416	164	32	,	,	PUNCT
dti-1416	164	33	which	which	PRON
dti-1416	164	34	selectively	selectively	ADV
dti-1416	164	35	maps	map	VERB
dti-1416	164	36	the	the	DET
dti-1416	164	37	proteincoding	proteincoding	NOUN
dti-1416	164	38	or	or	CCONJ
dti-1416	164	39	exon	exon	ADJ
dti-1416	164	40	regions	region	NOUN
dti-1416	164	41	of	of	ADP
dti-1416	164	42	the	the	DET
dti-1416	164	43	genes	gene	NOUN
dti-1416	164	44	.	.	PUNCT
dti-1416	165	1	the	the	DET
dti-1416	165	2	hgp	hgp	PROPN
dti-1416	165	3	spent	spend	VERB
dti-1416	165	4	in	in	ADP
dti-1416	165	5	excess	excess	NOUN
dti-1416	165	6	of	of	ADP
dti-1416	165	7	$	$	SYM
dti-1416	165	8	500	500	NUM
dti-1416	165	9	million	million	NUM
dti-1416	165	10	and	and	CCONJ
dti-1416	165	11	took	take	VERB
dti-1416	165	12	over	over	ADP
dti-1416	165	13	10	10	NUM
dti-1416	165	14	years	year	NOUN
dti-1416	165	15	to	to	PART
dti-1416	165	16	sequence	sequence	VERB
dti-1416	165	17	the	the	DET
dti-1416	165	18	first	first	ADJ
dti-1416	165	19	single	single	ADJ
dti-1416	165	20	reference	reference	NOUN
dti-1416	165	21	human	human	PROPN
dti-1416	165	22	genome.30	genome.30	NOUN
dti-1416	165	23	by	by	ADP
dti-1416	165	24	comparison	comparison	NOUN
dti-1416	165	25	,	,	PUNCT
dti-1416	165	26	in	in	ADP
dti-1416	165	27	2018	2018	NUM
dti-1416	165	28	,	,	PUNCT
dti-1416	165	29	wgs	wgs	NOUN
dti-1416	165	30	conducted	conduct	VERB
dti-1416	165	31	in	in	ADP
dti-1416	165	32	standard	standard	ADJ
dti-1416	165	33	clinical	clinical	ADJ
dti-1416	165	34	practice	practice	NOUN
dti-1416	165	35	can	can	AUX
dti-1416	165	36	deliver	deliver	VERB
dti-1416	165	37	results	result	NOUN
dti-1416	165	38	in	in	ADP
dti-1416	165	39	2	2	NUM
dti-1416	165	40	to	to	PART
dti-1416	165	41	8	8	NUM
dti-1416	165	42	weeks	week	NOUN
dti-1416	165	43	at	at	ADP
dti-1416	165	44	a	a	DET
dti-1416	165	45	cost	cost	NOUN
dti-1416	165	46	of	of	ADP
dti-1416	165	47	less	less	ADJ
dti-1416	165	48	than	than	ADP
dti-1416	165	49	$	$	SYM
dti-1416	165	50	1000	1000	NUM
dti-1416	165	51	.	.	PUNCT
dti-1416	166	1	testing	test	VERB
dti-1416	166	2	for	for	ADP
dti-1416	166	3	targeted	target	VERB
dti-1416	166	4	gene	gene	NOUN
dti-1416	166	5	variants	variant	NOUN
dti-1416	166	6	can	can	AUX
dti-1416	166	7	be	be	AUX
dti-1416	166	8	accomplished	accomplish	VERB
dti-1416	166	9	in	in	ADP
dti-1416	166	10	a	a	DET
dti-1416	166	11	matter	matter	NOUN
dti-1416	166	12	of	of	ADP
dti-1416	166	13	days	day	NOUN
dti-1416	166	14	at	at	ADP
dti-1416	166	15	a	a	DET
dti-1416	166	16	cost	cost	NOUN
dti-1416	166	17	of	of	ADP
dti-1416	166	18	a	a	DET
dti-1416	166	19	few	few	ADJ
dti-1416	166	20	hundred	hundred	NUM
dti-1416	166	21	dollars	dollar	NOUN
dti-1416	166	22	.	.	PUNCT
dti-1416	167	1	in	in	ADP
dti-1416	167	2	1977	1977	NUM
dti-1416	167	3	,	,	PUNCT
dti-1416	167	4	frederick	frederick	PROPN
dti-1416	167	5	sanger	sanger	PROPN
dti-1416	167	6	developed	develop	VERB
dti-1416	167	7	the	the	DET
dti-1416	167	8	original	original	ADJ
dti-1416	167	9	base	base	NOUN
dti-1416	167	10	sequencing	sequence	VERB
dti-1416	167	11	technique	technique	NOUN
dti-1416	167	12	that	that	PRON
dti-1416	167	13	involved	involve	VERB
dti-1416	167	14	cleaving	cleave	VERB
dti-1416	167	15	1	1	NUM
dti-1416	167	16	strand	strand	NOUN
dti-1416	167	17	of	of	ADP
dti-1416	167	18	the	the	DET
dti-1416	167	19	dna	dna	PROPN
dti-1416	167	20	molecule	molecule	NOUN
dti-1416	167	21	into	into	ADP
dti-1416	167	22	millions	million	NOUN
dti-1416	167	23	of	of	ADP
dti-1416	167	24	pieces	piece	NOUN
dti-1416	167	25	,	,	PUNCT
dti-1416	167	26	copying	copying	NOUN
dti-1416	167	27	or	or	CCONJ
dti-1416	167	28	amplifying	amplify	VERB
dti-1416	167	29	the	the	DET
dti-1416	167	30	fragments	fragment	NOUN
dti-1416	167	31	,	,	PUNCT
dti-1416	167	32	and	and	CCONJ
dti-1416	167	33	painstakingly	painstakingly	ADV
dti-1416	167	34	identifying	identify	VERB
dti-1416	167	35	the	the	DET
dti-1416	167	36	terminal	terminal	ADJ
dti-1416	167	37	nitrogenous	nitrogenous	ADJ
dti-1416	167	38	base	base	NOUN
dti-1416	167	39	in	in	ADP
dti-1416	167	40	each	each	DET
dti-1416	167	41	fragment	fragment	NOUN
dti-1416	167	42	by	by	ADP
dti-1416	167	43	tagging	tag	VERB
dti-1416	167	44	it	it	PRON
dti-1416	167	45	with	with	ADP
dti-1416	167	46	a	a	DET
dti-1416	167	47	radioactive	radioactive	ADJ
dti-1416	167	48	or	or	CCONJ
dti-1416	167	49	fluorescent	fluorescent	ADJ
dti-1416	167	50	complementary	complementary	ADJ
dti-1416	167	51	base	base	NOUN
dti-1416	167	52	.	.	PUNCT
dti-1416	168	1	the	the	DET
dti-1416	168	2	hgp	hgp	PROPN
dti-1416	168	3	used	use	VERB
dti-1416	168	4	an	an	DET
dti-1416	168	5	updated	update	VERB
dti-1416	168	6	version	version	NOUN
dti-1416	168	7	of	of	ADP
dti-1416	168	8	the	the	DET
dti-1416	168	9	sanger	sanger	PROPN
dti-1416	168	10	method	method	NOUN
dti-1416	168	11	that	that	PRON
dti-1416	168	12	automated	automate	VERB
dti-1416	168	13	the	the	DET
dti-1416	168	14	process	process	NOUN
dti-1416	168	15	and	and	CCONJ
dti-1416	168	16	allowed	allow	VERB
dti-1416	168	17	multiple	multiple	ADJ
dti-1416	168	18	fragments	fragment	NOUN
dti-1416	168	19	to	to	PART
dti-1416	168	20	be	be	AUX
dti-1416	168	21	tested	test	VERB
dti-1416	168	22	at	at	ADP
dti-1416	168	23	one	one	NUM
dti-1416	168	24	time	time	NOUN
dti-1416	168	25	.	.	PUNCT
dti-1416	169	1	today	today	NOUN
dti-1416	169	2	’s	’s	PART
dti-1416	169	3	technologies	technology	NOUN
dti-1416	169	4	called	call	VERB
dti-1416	169	5	next	next	ADJ
dti-1416	169	6	-	-	PUNCT
dti-1416	169	7	generation	generation	NOUN
dti-1416	169	8	or	or	CCONJ
dti-1416	169	9	high	high	ADJ
dti-1416	169	10	-	-	PUNCT
dti-1416	169	11	throughput	throughput	NOUN
dti-1416	169	12	sequencing	sequencing	NOUN
dti-1416	169	13	can	can	AUX
dti-1416	169	14	sequence	sequence	VERB
dti-1416	169	15	millions	million	NOUN
dti-1416	169	16	of	of	ADP
dti-1416	169	17	dna	dna	PROPN
dti-1416	169	18	fragments	fragment	NOUN
dti-1416	169	19	simultaneously	simultaneously	ADV
dti-1416	169	20	and	and	CCONJ
dti-1416	169	21	process	process	VERB
dti-1416	169	22	dna	dna	NOUN
dti-1416	169	23	from	from	ADP
dti-1416	169	24	multiple	multiple	ADJ
dti-1416	169	25	individuals	individual	NOUN
dti-1416	169	26	at	at	ADP
dti-1416	169	27	the	the	DET
dti-1416	169	28	same	same	ADJ
dti-1416	169	29	time.31	time.31	ADP
dti-1416	169	30	an	an	DET
dti-1416	169	31	entire	entire	ADJ
dti-1416	169	32	genetic	genetic	ADJ
dti-1416	169	33	testing	testing	NOUN
dti-1416	169	34	industry	industry	NOUN
dti-1416	169	35	has	have	AUX
dti-1416	169	36	arisen	arise	VERB
dti-1416	169	37	devoted	devote	VERB
dti-1416	169	38	to	to	ADP
dti-1416	169	39	exploring	explore	VERB
dti-1416	169	40	new	new	ADJ
dti-1416	169	41	technologies	technology	NOUN
dti-1416	169	42	and	and	CCONJ
dti-1416	169	43	marketing	marketing	NOUN
dti-1416	169	44	services	service	NOUN
dti-1416	169	45	not	not	PART
dti-1416	169	46	only	only	ADV
dti-1416	169	47	to	to	ADP
dti-1416	169	48	health	health	NOUN
dti-1416	169	49	care	care	NOUN
dti-1416	169	50	providers	provider	NOUN
dti-1416	169	51	but	but	CCONJ
dti-1416	169	52	directly	directly	ADV
dti-1416	169	53	to	to	ADP
dti-1416	169	54	consumers.32	consumers.32	PROPN
dti-1416	169	55	perhaps	perhaps	ADV
dti-1416	169	56	because	because	SCONJ
dti-1416	169	57	of	of	ADP
dti-1416	169	58	the	the	DET
dti-1416	169	59	success	success	NOUN
dti-1416	169	60	and	and	CCONJ
dti-1416	169	61	public	public	ADJ
dti-1416	169	62	receptivity	receptivity	NOUN
dti-1416	169	63	of	of	ADP
dti-1416	169	64	ancestry	ancestry	NOUN
dti-1416	169	65	genetic	genetic	ADJ
dti-1416	169	66	testing	testing	NOUN
dti-1416	169	67	,	,	PUNCT
dti-1416	169	68	personal	personal	ADJ
dti-1416	169	69	medical	medical	ADJ
dti-1416	169	70	testing	testing	NOUN
dti-1416	169	71	is	be	AUX
dti-1416	169	72	being	be	AUX
dti-1416	169	73	marketed	market	VERB
dti-1416	169	74	directly	directly	ADV
dti-1416	169	75	to	to	ADP
dti-1416	169	76	the	the	DET
dti-1416	169	77	public	public	NOUN
dti-1416	169	78	with	with	ADP
dti-1416	169	79	at	at	ADP
dti-1416	169	80	-	-	PUNCT
dti-1416	169	81	home	home	NOUN
dti-1416	169	82	dna	dna	PROPN
dti-1416	169	83	sample	sample	NOUN
dti-1416	169	84	collection	collection	NOUN
dti-1416	169	85	.	.	PUNCT
dti-1416	170	1	many	many	ADJ
dti-1416	170	2	companies	company	NOUN
dti-1416	170	3	offer	offer	VERB
dti-1416	170	4	clinical	clinical	ADJ
dti-1416	170	5	-	-	PUNCT
dti-1416	170	6	grade	grade	NOUN
dti-1416	170	7	genetic	genetic	ADJ
dti-1416	170	8	testing	testing	NOUN
dti-1416	170	9	after	after	ADP
dti-1416	170	10	delivery	delivery	NOUN
dti-1416	170	11	of	of	ADP
dti-1416	170	12	a	a	DET
dti-1416	170	13	saliva	saliva	NOUN
dti-1416	170	14	sample	sample	NOUN
dti-1416	170	15	and	and	CCONJ
dti-1416	170	16	some	some	PRON
dti-1416	170	17	but	but	CCONJ
dti-1416	170	18	not	not	PART
dti-1416	170	19	all	all	PRON
dti-1416	170	20	require	require	VERB
dti-1416	170	21	a	a	DET
dti-1416	170	22	physician	physician	NOUN
dti-1416	170	23	’s	’s	PART
dti-1416	170	24	order	order	NOUN
dti-1416	170	25	.	.	PUNCT
dti-1416	171	1	typically	typically	ADV
dti-1416	171	2	,	,	PUNCT
dti-1416	171	3	a	a	DET
dti-1416	171	4	package	package	NOUN
dti-1416	171	5	of	of	ADP
dti-1416	171	6	targeted	target	VERB
dti-1416	171	7	genes	gene	NOUN
dti-1416	171	8	intended	intend	VERB
dti-1416	171	9	to	to	PART
dti-1416	171	10	screen	screen	VERB
dti-1416	171	11	for	for	ADP
dti-1416	171	12	an	an	DET
dti-1416	171	13	individual	individual	NOUN
dti-1416	171	14	’s	’s	PART
dti-1416	171	15	risk	risk	NOUN
dti-1416	171	16	for	for	ADP
dti-1416	171	17	developing	develop	VERB
dti-1416	171	18	specific	specific	ADJ
dti-1416	171	19	diseases	disease	NOUN
dti-1416	171	20	are	be	AUX
dti-1416	171	21	characterized	characterize	VERB
dti-1416	171	22	.	.	PUNCT
dti-1416	172	1	several	several	ADJ
dti-1416	172	2	companies	company	NOUN
dti-1416	172	3	offer	offer	VERB
dti-1416	172	4	to	to	PART
dti-1416	172	5	test	test	VERB
dti-1416	172	6	for	for	ADP
dti-1416	172	7	gene	gene	NOUN
dti-1416	172	8	variants	variant	NOUN
dti-1416	172	9	predictive	predictive	ADJ
dti-1416	172	10	of	of	ADP
dti-1416	172	11	cancers	cancer	NOUN
dti-1416	172	12	or	or	CCONJ
dti-1416	172	13	inherited	inherit	VERB
dti-1416	172	14	cardiovascular	cardiovascular	ADJ
dti-1416	172	15	diseases	disease	NOUN
dti-1416	172	16	such	such	ADJ
dti-1416	172	17	as	as	ADP
dti-1416	172	18	cardiomyopathy	cardiomyopathy	ADJ
dti-1416	172	19	.	.	PUNCT
dti-1416	173	1	a	a	DET
dti-1416	173	2	few	few	ADJ
dti-1416	173	3	companies	company	NOUN
dti-1416	173	4	specifically	specifically	ADV
dti-1416	173	5	offer	offer	VERB
dti-1416	173	6	pgx	pgx	PROPN
dti-1416	173	7	testing	testing	NOUN
dti-1416	173	8	with	with	ADP
dti-1416	173	9	1	1	NUM
dti-1416	173	10	testing	testing	NOUN
dti-1416	173	11	for	for	ADP
dti-1416	173	12	50	50	NUM
dti-1416	173	13	pharmacogenes	pharmacogene	NOUN
dti-1416	173	14	.	.	PUNCT
dti-1416	174	1	the	the	DET
dti-1416	174	2	directto	directto	ADJ
dti-1416	174	3	-	-	PUNCT
dti-1416	174	4	consumer	consumer	NOUN
dti-1416	174	5	marketing	marketing	NOUN
dti-1416	174	6	of	of	ADP
dti-1416	174	7	genetic	genetic	ADJ
dti-1416	174	8	testing	testing	NOUN
dti-1416	174	9	places	place	VERB
dti-1416	174	10	the	the	DET
dti-1416	174	11	results	result	NOUN
dti-1416	174	12	into	into	ADP
dti-1416	174	13	the	the	DET
dti-1416	174	14	consumer	consumer	NOUN
dti-1416	174	15	’s	’s	PART
dti-1416	174	16	hands	hand	NOUN
dti-1416	174	17	,	,	PUNCT
dti-1416	174	18	and	and	CCONJ
dti-1416	174	19	while	while	SCONJ
dti-1416	174	20	most	most	ADJ
dti-1416	174	21	companies	company	NOUN
dti-1416	174	22	offer	offer	VERB
dti-1416	174	23	access	access	NOUN
dti-1416	174	24	to	to	ADP
dti-1416	174	25	genetic	genetic	ADJ
dti-1416	174	26	counselors	counselor	NOUN
dti-1416	174	27	or	or	CCONJ
dti-1416	174	28	help	help	VERB
dti-1416	174	29	lines	line	NOUN
dti-1416	174	30	,	,	PUNCT
dti-1416	174	31	people	people	NOUN
dti-1416	174	32	are	be	AUX
dti-1416	174	33	often	often	ADV
dti-1416	174	34	directed	direct	VERB
dti-1416	174	35	to	to	PART
dti-1416	174	36	discuss	discuss	VERB
dti-1416	174	37	testing	testing	NOUN
dti-1416	174	38	results	result	NOUN
dti-1416	174	39	with	with	ADP
dti-1416	174	40	their	their	PRON
dti-1416	174	41	health	health	NOUN
dti-1416	174	42	care	care	NOUN
dti-1416	174	43	providers	provider	NOUN
dti-1416	174	44	.	.	PUNCT
dti-1416	175	1	pharmacists	pharmacist	NOUN
dti-1416	175	2	may	may	AUX
dti-1416	175	3	be	be	AUX
dti-1416	175	4	called	call	VERB
dti-1416	175	5	upon	upon	SCONJ
dti-1416	175	6	to	to	PART
dti-1416	175	7	evaluate	evaluate	VERB
dti-1416	175	8	a	a	DET
dti-1416	175	9	person	person	NOUN
dti-1416	175	10	’s	’s	PART
dti-1416	175	11	drug	drug	NOUN
dti-1416	175	12	regimen	regiman	NOUN
dti-1416	175	13	and	and	CCONJ
dti-1416	175	14	tailor	tailor	NOUN
dti-1416	175	15	it	it	PRON
dti-1416	175	16	based	base	VERB
dti-1416	175	17	on	on	ADP
dti-1416	175	18	pgx	pgx	PROPN
dti-1416	175	19	test	test	NOUN
dti-1416	175	20	results	result	NOUN
dti-1416	175	21	.	.	PUNCT
dti-1416	176	1	reports	report	NOUN
dti-1416	176	2	usually	usually	ADV
dti-1416	176	3	include	include	VERB
dti-1416	176	4	a	a	DET
dti-1416	176	5	clinical	clinical	ADJ
dti-1416	176	6	interpretation	interpretation	NOUN
dti-1416	176	7	to	to	PART
dti-1416	176	8	help	help	VERB
dti-1416	176	9	the	the	DET
dti-1416	176	10	recipient	recipient	NOUN
dti-1416	176	11	understand	understand	VERB
dti-1416	176	12	the	the	DET
dti-1416	176	13	implications	implication	NOUN
dti-1416	176	14	of	of	ADP
dti-1416	176	15	the	the	DET
dti-1416	176	16	test	test	NOUN
dti-1416	176	17	.	.	PUNCT
dti-1416	177	1	if	if	SCONJ
dti-1416	177	2	presented	present	VERB
dti-1416	177	3	with	with	ADP
dti-1416	177	4	a	a	DET
dti-1416	177	5	report	report	NOUN
dti-1416	177	6	from	from	ADP
dti-1416	177	7	a	a	DET
dti-1416	177	8	patient	patient	NOUN
dti-1416	177	9	,	,	PUNCT
dti-1416	177	10	accessing	access	VERB
dti-1416	177	11	the	the	DET
dti-1416	177	12	company	company	NOUN
dti-1416	177	13	’s	’s	PART
dti-1416	177	14	website	website	NOUN
dti-1416	177	15	to	to	PART
dti-1416	177	16	obtain	obtain	VERB
dti-1416	177	17	more	more	ADJ
dti-1416	177	18	information	information	NOUN
dti-1416	177	19	about	about	ADP
dti-1416	177	20	which	which	PRON
dti-1416	177	21	genes	gene	NOUN
dti-1416	177	22	are	be	AUX
dti-1416	177	23	tested	test	VERB
dti-1416	177	24	and	and	CCONJ
dti-1416	177	25	access	access	VERB
dti-1416	177	26	clinical	clinical	ADJ
dti-1416	177	27	decision	decision	NOUN
dti-1416	177	28	support	support	NOUN
dti-1416	177	29	tools	tool	NOUN
dti-1416	177	30	may	may	AUX
dti-1416	177	31	be	be	AUX
dti-1416	177	32	helpful	helpful	ADJ
dti-1416	177	33	.	.	PUNCT
dti-1416	178	1	certainly	certainly	ADV
dti-1416	178	2	,	,	PUNCT
dti-1416	178	3	consulting	consult	VERB
dti-1416	178	4	pharmgkb	pharmgkb	NOUN
dti-1416	178	5	and	and	CCONJ
dti-1416	178	6	cpic	cpic	NOUN
dti-1416	178	7	guidelines	guideline	NOUN
dti-1416	178	8	will	will	AUX
dti-1416	178	9	be	be	AUX
dti-1416	178	10	useful	useful	ADJ
dti-1416	178	11	.	.	PUNCT
dti-1416	179	1	conclusions	conclusion	NOUN
dti-1416	179	2	pharmacists	pharmacist	NOUN
dti-1416	179	3	are	be	AUX
dti-1416	179	4	the	the	DET
dti-1416	179	5	ideal	ideal	ADJ
dti-1416	179	6	providers	provider	NOUN
dti-1416	179	7	to	to	PART
dti-1416	179	8	orchestrate	orchestrate	VERB
dti-1416	179	9	the	the	DET
dti-1416	179	10	translation	translation	NOUN
dti-1416	179	11	of	of	ADP
dti-1416	179	12	pgx	pgx	PROPN
dti-1416	179	13	gene	gene	NOUN
dti-1416	179	14	-	-	PUNCT
dti-1416	179	15	drug	drug	NOUN
dti-1416	179	16	associations	association	NOUN
dti-1416	179	17	into	into	ADP
dti-1416	179	18	clinical	clinical	ADJ
dti-1416	179	19	practice	practice	NOUN
dti-1416	179	20	and	and	CCONJ
dti-1416	179	21	improve	improve	VERB
dti-1416	179	22	patient	patient	ADJ
dti-1416	179	23	care	care	NOUN
dti-1416	179	24	.	.	PUNCT
dti-1416	180	1	knowing	know	VERB
dti-1416	180	2	the	the	DET
dti-1416	180	3	genetic	genetic	ADJ
dti-1416	180	4	information	information	NOUN
dti-1416	180	5	of	of	ADP
dti-1416	180	6	our	our	PRON
dti-1416	180	7	patients	patient	NOUN
dti-1416	180	8	adds	add	VERB
dti-1416	180	9	complexity	complexity	NOUN
dti-1416	180	10	to	to	ADP
dti-1416	180	11	treatment	treatment	NOUN
dti-1416	180	12	options	option	NOUN
dti-1416	180	13	and	and	CCONJ
dti-1416	180	14	gives	give	VERB
dti-1416	180	15	us	we	PRON
dti-1416	180	16	new	new	ADJ
dti-1416	180	17	attributes	attribute	NOUN
dti-1416	180	18	to	to	PART
dti-1416	180	19	consider	consider	VERB
dti-1416	180	20	when	when	SCONJ
dti-1416	180	21	personalizing	personalize	VERB
dti-1416	180	22	the	the	DET
dti-1416	180	23	selection	selection	NOUN
dti-1416	180	24	,	,	PUNCT
dti-1416	180	25	dosing	dosing	NOUN
dti-1416	180	26	,	,	PUNCT
dti-1416	180	27	and	and	CCONJ
dti-1416	180	28	monitoring	monitoring	NOUN
dti-1416	180	29	of	of	ADP
dti-1416	180	30	drug	drug	NOUN
dti-1416	180	31	therapy	therapy	NOUN
dti-1416	180	32	.	.	PUNCT
dti-1416	181	1	discovering	discover	VERB
dti-1416	181	2	and	and	CCONJ
dti-1416	181	3	getting	getting	AUX
dti-1416	181	4	involved	involve	VERB
dti-1416	181	5	with	with	ADP
dti-1416	181	6	committees	committee	NOUN
dti-1416	181	7	focused	focus	VERB
dti-1416	181	8	on	on	ADP
dti-1416	181	9	genomic	genomic	ADJ
dti-1416	181	10	medicine	medicine	NOUN
dti-1416	181	11	at	at	ADP
dti-1416	181	12	your	your	PRON
dti-1416	181	13	institution	institution	NOUN
dti-1416	181	14	is	be	AUX
dti-1416	181	15	important	important	ADJ
dti-1416	181	16	for	for	ADP
dti-1416	181	17	establishing	establish	VERB
dti-1416	181	18	our	our	PRON
dti-1416	181	19	eventual	eventual	ADJ
dti-1416	181	20	role	role	NOUN
dti-1416	181	21	early	early	ADV
dti-1416	181	22	-	-	PUNCT
dti-1416	181	23	on	on	ADV
dti-1416	181	24	.	.	PUNCT
dti-1416	182	1	consider	consider	VERB
dti-1416	182	2	adding	add	VERB
dti-1416	182	3	pgx	pgx	PROPN
dti-1416	182	4	subcommittees	subcommittee	NOUN
dti-1416	182	5	to	to	ADP
dti-1416	182	6	established	establish	VERB
dti-1416	182	7	pharmacy	pharmacy	NOUN
dti-1416	182	8	committees	committee	NOUN
dti-1416	182	9	such	such	ADJ
dti-1416	182	10	as	as	ADP
dti-1416	182	11	pharmacy	pharmacy	NOUN
dti-1416	182	12	and	and	CCONJ
dti-1416	182	13	therapeutics	therapeutic	NOUN
dti-1416	182	14	and	and	CCONJ
dti-1416	182	15	medication	medication	NOUN
dti-1416	182	16	safety	safety	NOUN
dti-1416	182	17	.	.	PUNCT
dti-1416	183	1	hopefully	hopefully	ADV
dti-1416	183	2	,	,	PUNCT
dti-1416	183	3	this	this	DET
dti-1416	183	4	review	review	NOUN
dti-1416	183	5	has	have	AUX
dti-1416	183	6	inspired	inspire	VERB
dti-1416	183	7	you	you	PRON
dti-1416	183	8	to	to	PART
dti-1416	183	9	embrace	embrace	VERB
dti-1416	183	10	this	this	DET
dti-1416	183	11	emerging	emerge	VERB
dti-1416	183	12	body	body	NOUN
dti-1416	183	13	of	of	ADP
dti-1416	183	14	knowledge	knowledge	NOUN
dti-1416	183	15	and	and	CCONJ
dti-1416	183	16	continue	continue	VERB
dti-1416	183	17	to	to	PART
dti-1416	183	18	learn	learn	VERB
dti-1416	183	19	about	about	ADP
dti-1416	183	20	new	new	ADJ
dti-1416	183	21	discoveries	discovery	NOUN
dti-1416	183	22	in	in	ADP
dti-1416	183	23	genomic	genomic	ADJ
dti-1416	183	24	medicine	medicine	NOUN
dti-1416	183	25	.	.	PUNCT
dti-1416	184	1	as	as	SCONJ
dti-1416	184	2	pgx	pgx	PROPN
dti-1416	184	3	driven	drive	VERB
dti-1416	184	4	drug	drug	NOUN
dti-1416	184	5	therapy	therapy	NOUN
dti-1416	184	6	advances	advance	NOUN
dti-1416	184	7	,	,	PUNCT
dti-1416	184	8	in	in	ADP
dti-1416	184	9	medical	medical	ADJ
dti-1416	184	10	science	science	NOUN
dti-1416	184	11	lead	lead	NOUN
dti-1416	184	12	to	to	ADP
dti-1416	184	13	a	a	DET
dti-1416	184	14	paradigm	paradigm	NOUN
dti-1416	184	15	shift	shift	NOUN
dti-1416	184	16	in	in	ADP
dti-1416	184	17	drug	drug	NOUN
dti-1416	184	18	discovery	discovery	NOUN
dti-1416	184	19	and	and	CCONJ
dti-1416	184	20	treatment	treatment	NOUN
dti-1416	184	21	,	,	PUNCT
dti-1416	184	22	it	it	PRON
dti-1416	184	23	is	be	AUX
dti-1416	184	24	both	both	PRON
dti-1416	184	25	necessary	necessary	ADJ
dti-1416	184	26	and	and	CCONJ
dti-1416	184	27	professionally	professionally	ADV
dti-1416	184	28	fulfilling	fulfil	VERB
dti-1416	184	29	to	to	PART
dti-1416	184	30	keep	keep	VERB
dti-1416	184	31	current	current	ADJ
dti-1416	184	32	and	and	CCONJ
dti-1416	184	33	practice	practice	VERB
dti-1416	184	34	ready	ready	ADJ
dti-1416	184	35	.	.	PUNCT
dti-1416	185	1	orrico	orrico	PROPN
dti-1416	185	2	7	7	NUM
dti-1416	185	3	orcid	orcid	NOUN
dti-1416	186	1	i	i	NOUN
dti-1416	186	2	d	d	NOUN
dti-1416	186	3	kathleen	kathleen	PROPN
dti-1416	186	4	b	b	PROPN
dti-1416	187	1	orrico	orrico	PROPN
dti-1416	187	2	https://orcid.org/0000-0001-9450-9040	https://orcid.org/0000-0001-9450-9040	VERB
dti-1416	187	3	supplemental	supplemental	ADJ
dti-1416	187	4	material	material	NOUN
dti-1416	187	5	supplemental	supplemental	ADJ
dti-1416	187	6	material	material	NOUN
dti-1416	187	7	for	for	ADP
dti-1416	187	8	this	this	DET
dti-1416	187	9	article	article	NOUN
dti-1416	187	10	is	be	AUX
dti-1416	187	11	available	available	ADJ
dti-1416	187	12	online	online	ADV
dti-1416	187	13	.	.	PUNCT
dti-1416	188	1	references	reference	NOUN
dti-1416	188	2	1	1	NUM
dti-1416	188	3	.	.	PUNCT
dti-1416	188	4	genetics	genetic	NOUN
dti-1416	188	5	home	home	NOUN
dti-1416	188	6	reference	reference	NOUN
dti-1416	188	7	.	.	PUNCT
dti-1416	189	1	what	what	PRON
dti-1416	189	2	is	be	AUX
dti-1416	189	3	pharmacogenomics	pharmacogenomic	NOUN
dti-1416	189	4	?	?	PUNCT
dti-1416	190	1	bethesda	bethesda	PROPN
dti-1416	190	2	,	,	PUNCT
dti-1416	190	3	md	md	PROPN
dti-1416	190	4	:	:	PUNCT
dti-1416	190	5	us	us	PROPN
dti-1416	190	6	national	national	PROPN
dti-1416	190	7	library	library	NOUN
dti-1416	190	8	of	of	ADP
dti-1416	190	9	medicine	medicine	NOUN
dti-1416	190	10	.	.	PUNCT
dti-1416	191	1	https://ghr.nlm.nih.gov/primer/genomicresearch/pharmacogenomics	https://ghr.nlm.nih.gov/primer/genomicresearch/pharmacogenomics	PROPN
dti-1416	191	2	.	.	PROPN
dti-1416	191	3	updated	update	VERB
dti-1416	191	4	july	july	PROPN
dti-1416	191	5	16	16	NUM
dti-1416	191	6	,	,	PUNCT
dti-1416	191	7	2019	2019	NUM
dti-1416	191	8	.	.	PUNCT
dti-1416	192	1	accessed	access	VERB
dti-1416	192	2	august	august	PROPN
dti-1416	192	3	6	6	NUM
dti-1416	192	4	,	,	PUNCT
dti-1416	192	5	2019	2019	NUM
dti-1416	192	6	.	.	PUNCT
dti-1416	193	1	2	2	X
dti-1416	193	2	.	.	X
dti-1416	193	3	all	all	ADV
dti-1416	193	4	about	about	ADP
dti-1416	193	5	the	the	DET
dti-1416	193	6	human	human	ADJ
dti-1416	193	7	genome	genome	NOUN
dti-1416	193	8	project	project	NOUN
dti-1416	193	9	(	(	PUNCT
dti-1416	193	10	hgp	hgp	PROPN
dti-1416	193	11	)	)	PUNCT
dti-1416	193	12	.	.	PUNCT
dti-1416	194	1	washington	washington	PROPN
dti-1416	194	2	,	,	PUNCT
dti-1416	194	3	dc	dc	PROPN
dti-1416	194	4	:	:	PUNCT
dti-1416	194	5	national	national	PROPN
dti-1416	194	6	institutes	institutes	PROPN
dti-1416	194	7	of	of	ADP
dti-1416	194	8	health	health	PROPN
dti-1416	194	9	,	,	PUNCT
dti-1416	194	10	national	national	ADJ
dti-1416	194	11	human	human	ADJ
dti-1416	194	12	genome	genome	NOUN
dti-1416	194	13	research	research	NOUN
dti-1416	194	14	institute	institute	NOUN
dti-1416	194	15	.	.	PUNCT
dti-1416	195	1	https://www	https://www	PROPN
dti-1416	195	2	.	.	PUNCT
dti-1416	195	3	genome.gov/human-genome-project	genome.gov/human-genome-project	PROPN
dti-1416	195	4	.	.	PUNCT
dti-1416	196	1	updated	update	VERB
dti-1416	196	2	january	january	PROPN
dti-1416	196	3	9	9	NUM
dti-1416	196	4	,	,	PUNCT
dti-1416	196	5	2019	2019	NUM
dti-1416	196	6	.	.	PUNCT
dti-1416	197	1	accessed	access	VERB
dti-1416	197	2	september	september	PROPN
dti-1416	197	3	1	1	NUM
dti-1416	197	4	,	,	PUNCT
dti-1416	197	5	2019	2019	NUM
dti-1416	197	6	.	.	PUNCT
dti-1416	198	1	3	3	X
dti-1416	198	2	.	.	X
dti-1416	198	3	venter	venter	PROPN
dti-1416	198	4	jc	jc	PROPN
dti-1416	198	5	,	,	PUNCT
dti-1416	198	6	adams	adams	PROPN
dti-1416	198	7	md	md	PROPN
dti-1416	198	8	,	,	PUNCT
dti-1416	198	9	myers	myers	PROPN
dti-1416	198	10	ew	ew	PROPN
dti-1416	198	11	,	,	PUNCT
dti-1416	198	12	et	et	PROPN
dti-1416	198	13	al	al	PROPN
dti-1416	198	14	.	.	PUNCT
dti-1416	199	1	the	the	DET
dti-1416	199	2	sequence	sequence	NOUN
dti-1416	199	3	of	of	ADP
dti-1416	199	4	the	the	DET
dti-1416	199	5	human	human	ADJ
dti-1416	199	6	genome	genome	NOUN
dti-1416	199	7	.	.	PUNCT
dti-1416	200	1	science	science	NOUN
dti-1416	200	2	.	.	PUNCT
dti-1416	201	1	2001;291:1304	2001;291:1304	NUM
dti-1416	201	2	-	-	SYM
dti-1416	201	3	1351	1351	NUM
dti-1416	201	4	.	.	PUNCT
dti-1416	202	1	4	4	X
dti-1416	202	2	.	.	X
dti-1416	202	3	the	the	DET
dti-1416	202	4	human	human	ADJ
dti-1416	202	5	proteome	proteome	PROPN
dti-1416	202	6	project	project	NOUN
dti-1416	202	7	.	.	PUNCT
dti-1416	203	1	vancouver	vancouver	PROPN
dti-1416	203	2	,	,	PUNCT
dti-1416	203	3	bc	bc	PROPN
dti-1416	203	4	,	,	PUNCT
dti-1416	203	5	canada	canada	PROPN
dti-1416	203	6	:	:	PUNCT
dti-1416	203	7	human	human	ADJ
dti-1416	203	8	proteome	proteome	PROPN
dti-1416	203	9	organization	organization	NOUN
dti-1416	203	10	.	.	PUNCT
dti-1416	204	1	https://hupo.org/human-proteome-project/.	https://hupo.org/human-proteome-project/.	PROPN
dti-1416	204	2	updated	update	VERB
dti-1416	204	3	2016	2016	NUM
dti-1416	204	4	.	.	PUNCT
dti-1416	205	1	accessed	access	VERB
dti-1416	205	2	september	september	PROPN
dti-1416	205	3	1	1	NUM
dti-1416	205	4	,	,	PUNCT
dti-1416	205	5	2019	2019	NUM
dti-1416	205	6	.	.	PUNCT
dti-1416	206	1	5	5	X
dti-1416	206	2	.	.	X
dti-1416	206	3	genetics	genetic	NOUN
dti-1416	206	4	home	home	NOUN
dti-1416	206	5	reference	reference	NOUN
dti-1416	206	6	.	.	PUNCT
dti-1416	207	1	what	what	PRON
dti-1416	207	2	is	be	AUX
dti-1416	207	3	dna	dna	PROPN
dti-1416	207	4	?	?	PUNCT
dti-1416	208	1	bethesda	bethesda	NOUN
dti-1416	208	2	,	,	PUNCT
dti-1416	208	3	md	md	PROPN
dti-1416	208	4	:	:	PUNCT
dti-1416	208	5	us	us	PROPN
dti-1416	208	6	national	national	PROPN
dti-1416	208	7	library	library	NOUN
dti-1416	208	8	of	of	ADP
dti-1416	208	9	medicine	medicine	NOUN
dti-1416	208	10	.	.	PUNCT
dti-1416	209	1	https://ghr.nlm.nih.gov/primer/basics/dna	https://ghr.nlm.nih.gov/primer/basics/dna	PUNCT
dti-1416	209	2	.	.	PUNCT
dti-1416	210	1	updated	update	VERB
dti-1416	210	2	august	august	PROPN
dti-1416	210	3	20	20	NUM
dti-1416	210	4	,	,	PUNCT
dti-1416	210	5	2019	2019	NUM
dti-1416	210	6	.	.	PUNCT
dti-1416	211	1	accessed	access	VERB
dti-1416	211	2	september	september	PROPN
dti-1416	211	3	2	2	NUM
dti-1416	211	4	,	,	PUNCT
dti-1416	211	5	2019	2019	NUM
dti-1416	211	6	.	.	PUNCT
dti-1416	212	1	6	6	NUM
dti-1416	212	2	.	.	X
dti-1416	212	3	national	national	ADJ
dti-1416	212	4	human	human	PROPN
dti-1416	212	5	genome	genome	PROPN
dti-1416	212	6	research	research	NOUN
dti-1416	212	7	institute	institute	NOUN
dti-1416	212	8	.	.	PUNCT
dti-1416	213	1	the	the	DET
dti-1416	213	2	human	human	ADJ
dti-1416	213	3	genome	genome	NOUN
dti-1416	213	4	project	project	NOUN
dti-1416	213	5	completion	completion	NOUN
dti-1416	213	6	:	:	PUNCT
dti-1416	213	7	frequently	frequently	ADV
dti-1416	213	8	asked	ask	VERB
dti-1416	213	9	questions	question	NOUN
dti-1416	213	10	.	.	PUNCT
dti-1416	214	1	what	what	PRON
dti-1416	214	2	is	be	AUX
dti-1416	214	3	dna	dna	NOUN
dti-1416	214	4	sequencing	sequence	VERB
dti-1416	214	5	?	?	PUNCT
dti-1416	215	1	https://	https://	PROPN
dti-1416	215	2	www.genome.gov/11006943/human-genome-project-completion-frequentlyasked-questions/.	www.genome.gov/11006943/human-genome-project-completion-frequentlyasked-questions/.	PROPN
dti-1416	215	3	updated	update	VERB
dti-1416	215	4	november	november	PROPN
dti-1416	215	5	12	12	NUM
dti-1416	215	6	,	,	PUNCT
dti-1416	215	7	2018	2018	NUM
dti-1416	215	8	.	.	PUNCT
dti-1416	216	1	accessed	access	VERB
dti-1416	216	2	september	september	PROPN
dti-1416	216	3	2	2	NUM
dti-1416	216	4	,	,	PUNCT
dti-1416	216	5	2019	2019	NUM
dti-1416	216	6	.	.	PUNCT
dti-1416	217	1	7	7	X
dti-1416	217	2	.	.	X
dti-1416	217	3	genetics	genetic	NOUN
dti-1416	217	4	home	home	NOUN
dti-1416	217	5	reference	reference	NOUN
dti-1416	217	6	.	.	PUNCT
dti-1416	218	1	what	what	PRON
dti-1416	218	2	is	be	AUX
dti-1416	218	3	a	a	DET
dti-1416	218	4	chromosome	chromosome	NOUN
dti-1416	218	5	?	?	PUNCT
dti-1416	219	1	bethesda	bethesda	NOUN
dti-1416	219	2	,	,	PUNCT
dti-1416	219	3	md	md	PROPN
dti-1416	219	4	:	:	PUNCT
dti-1416	219	5	us	us	PROPN
dti-1416	219	6	national	national	PROPN
dti-1416	219	7	library	library	NOUN
dti-1416	219	8	of	of	ADP
dti-1416	219	9	medicine	medicine	NOUN
dti-1416	219	10	.	.	PUNCT
dti-1416	220	1	https://ghr.nlm.nih.gov/primer/basics/chromosome	https://ghr.nlm.nih.gov/primer/basics/chromosome	PROPN
dti-1416	220	2	.	.	PUNCT
dti-1416	220	3	update	update	NOUN
dti-1416	220	4	august	august	PROPN
dti-1416	220	5	20	20	NUM
dti-1416	220	6	,	,	PUNCT
dti-1416	220	7	2019	2019	NUM
dti-1416	220	8	.	.	PUNCT
dti-1416	221	1	accessed	access	VERB
dti-1416	221	2	september	september	PROPN
dti-1416	221	3	2	2	NUM
dti-1416	221	4	,	,	PUNCT
dti-1416	221	5	2019	2019	NUM
dti-1416	221	6	.	.	PUNCT
dti-1416	222	1	8	8	NUM
dti-1416	222	2	.	.	X
dti-1416	223	1	shammas	shammas	PROPN
dti-1416	223	2	ma	ma	PROPN
dti-1416	223	3	.	.	PROPN
dti-1416	223	4	telomeres	telomere	NOUN
dti-1416	223	5	,	,	PUNCT
dti-1416	223	6	lifestyle	lifestyle	NOUN
dti-1416	223	7	,	,	PUNCT
dti-1416	223	8	cancer	cancer	NOUN
dti-1416	223	9	,	,	PUNCT
dti-1416	223	10	and	and	CCONJ
dti-1416	223	11	aging	aging	NOUN
dti-1416	223	12	.	.	PUNCT
dti-1416	224	1	curr	curr	PROPN
dti-1416	224	2	opin	opin	PROPN
dti-1416	224	3	clin	clin	PROPN
dti-1416	224	4	nutr	nutr	PROPN
dti-1416	224	5	metab	metab	PROPN
dti-1416	224	6	care	care	NOUN
dti-1416	224	7	.	.	PUNCT
dti-1416	225	1	2011;14:28	2011;14:28	NUM
dti-1416	225	2	-	-	SYM
dti-1416	225	3	34	34	NUM
dti-1416	225	4	.	.	PUNCT
dti-1416	226	1	doi:10.1097	doi:10.1097	PROPN
dti-1416	226	2	/	/	SYM
dti-1416	226	3	mco.0b013e32834121b1	mco.0b013e32834121b1	NOUN
dti-1416	226	4	.	.	PUNCT
dti-1416	227	1	9	9	X
dti-1416	227	2	.	.	X
dti-1416	227	3	genetics	genetic	NOUN
dti-1416	227	4	home	home	NOUN
dti-1416	227	5	reference	reference	NOUN
dti-1416	227	6	.	.	PUNCT
dti-1416	228	1	how	how	SCONJ
dti-1416	228	2	are	be	AUX
dti-1416	228	3	genetic	genetic	ADJ
dti-1416	228	4	conditions	condition	NOUN
dti-1416	228	5	and	and	CCONJ
dti-1416	228	6	genes	gene	NOUN
dti-1416	228	7	named	name	VERB
dti-1416	228	8	?	?	PUNCT
dti-1416	229	1	bethesda	bethesda	PROPN
dti-1416	229	2	,	,	PUNCT
dti-1416	229	3	md	md	PROPN
dti-1416	229	4	:	:	PUNCT
dti-1416	229	5	us	us	PROPN
dti-1416	229	6	national	national	PROPN
dti-1416	229	7	library	library	NOUN
dti-1416	229	8	of	of	ADP
dti-1416	229	9	medicine	medicine	NOUN
dti-1416	229	10	.	.	PUNCT
dti-1416	230	1	https://ghr.nlm.nih.gov/	https://ghr.nlm.nih.gov/	NUM
dti-1416	230	2	primer	primer	NOUN
dti-1416	230	3	/	/	SYM
dti-1416	230	4	mutationsanddisorders	mutationsanddisorder	NOUN
dti-1416	230	5	/	/	SYM
dti-1416	230	6	naming	naming	NOUN
dti-1416	230	7	.	.	PUNCT
dti-1416	231	1	updated	update	VERB
dti-1416	231	2	august	august	PROPN
dti-1416	231	3	20	20	NUM
dti-1416	231	4	,	,	PUNCT
dti-1416	231	5	2019	2019	NUM
dti-1416	231	6	.	.	PUNCT
dti-1416	232	1	accessed	access	VERB
dti-1416	232	2	september	september	PROPN
dti-1416	232	3	2	2	NUM
dti-1416	232	4	,	,	PUNCT
dti-1416	232	5	2019	2019	NUM
dti-1416	232	6	.	.	PUNCT
dti-1416	233	1	10	10	NUM
dti-1416	233	2	.	.	X
dti-1416	234	1	whirl	whirl	NOUN
dti-1416	234	2	-	-	PUNCT
dti-1416	234	3	carrillo	carrillo	PROPN
dti-1416	234	4	m	m	PROPN
dti-1416	234	5	,	,	PUNCT
dti-1416	234	6	mcdonagh	mcdonagh	PROPN
dti-1416	234	7	em	em	PRON
dti-1416	234	8	,	,	PUNCT
dti-1416	234	9	hebert	hebert	PROPN
dti-1416	234	10	jm	jm	PROPN
dti-1416	234	11	,	,	PUNCT
dti-1416	234	12	et	et	PROPN
dti-1416	234	13	al	al	PROPN
dti-1416	234	14	.	.	PROPN
dti-1416	234	15	pharmacogenomics	pharmacogenomic	NOUN
dti-1416	234	16	knowledge	knowledge	NOUN
dti-1416	234	17	for	for	ADP
dti-1416	234	18	personalized	personalized	ADJ
dti-1416	234	19	medicine	medicine	NOUN
dti-1416	234	20	.	.	PUNCT
dti-1416	235	1	clin	clin	PROPN
dti-1416	235	2	pharmacol	pharmacol	PROPN
dti-1416	235	3	ther	ther	ADV
dti-1416	235	4	.	.	PUNCT
dti-1416	236	1	2012;92(4):414	2012;92(4):414	NUM
dti-1416	236	2	-	-	SYM
dti-1416	236	3	417	417	NUM
dti-1416	236	4	.	.	PUNCT
dti-1416	236	5	doi:10.1038	doi:10.1038	NOUN
dti-1416	236	6	/	/	SYM
dti-1416	236	7	clpt.2012.96	clpt.2012.96	NOUN
dti-1416	236	8	.	.	PUNCT
dti-1416	237	1	11	11	NUM
dti-1416	237	2	.	.	X
dti-1416	238	1	talking	talk	VERB
dti-1416	238	2	glossary	glossary	NOUN
dti-1416	238	3	of	of	ADP
dti-1416	238	4	genetic	genetic	ADJ
dti-1416	238	5	terms	term	NOUN
dti-1416	238	6	.	.	PUNCT
dti-1416	239	1	washington	washington	PROPN
dti-1416	239	2	,	,	PUNCT
dti-1416	239	3	dc	dc	PROPN
dti-1416	239	4	:	:	PUNCT
dti-1416	239	5	national	national	PROPN
dti-1416	239	6	institutes	institutes	PROPN
dti-1416	239	7	of	of	ADP
dti-1416	239	8	health	health	PROPN
dti-1416	239	9	,	,	PUNCT
dti-1416	239	10	national	national	ADJ
dti-1416	239	11	human	human	ADJ
dti-1416	239	12	genome	genome	NOUN
dti-1416	239	13	research	research	NOUN
dti-1416	239	14	institute	institute	NOUN
dti-1416	239	15	.	.	PUNCT
dti-1416	240	1	https://www.genome	https://www.genome	PROPN
dti-1416	240	2	.	.	PUNCT
dti-1416	241	1	gov	gov	PROPN
dti-1416	241	2	/	/	SYM
dti-1416	241	3	glossary/.	glossary/.	PROPN
dti-1416	241	4	updated	update	VERB
dti-1416	241	5	march	march	PROPN
dti-1416	241	6	26	26	NUM
dti-1416	241	7	,	,	PUNCT
dti-1416	241	8	2019	2019	NUM
dti-1416	241	9	.	.	PUNCT
dti-1416	242	1	accessed	access	VERB
dti-1416	242	2	september	september	PROPN
dti-1416	242	3	2	2	NUM
dti-1416	242	4	,	,	PUNCT
dti-1416	242	5	2019	2019	NUM
dti-1416	242	6	.	.	PUNCT
dti-1416	243	1	12	12	NUM
dti-1416	243	2	.	.	PUNCT
dti-1416	244	1	johnson	johnson	PROPN
dti-1416	244	2	ja	ja	PROPN
dti-1416	244	3	,	,	PUNCT
dti-1416	244	4	cavallari	cavallari	PROPN
dti-1416	244	5	lh	lh	PROPN
dti-1416	244	6	,	,	PUNCT
dti-1416	244	7	touyz	touyz	PROPN
dti-1416	244	8	rm	rm	PROPN
dti-1416	244	9	.	.	PUNCT
dti-1416	244	10	pharmacogenetics	pharmacogenetic	NOUN
dti-1416	244	11	and	and	CCONJ
dti-1416	244	12	cardiovascular	cardiovascular	ADJ
dti-1416	244	13	disease	disease	NOUN
dti-1416	244	14	—	—	PUNCT
dti-1416	244	15	implications	implication	NOUN
dti-1416	244	16	for	for	ADP
dti-1416	244	17	personalized	personalized	ADJ
dti-1416	244	18	medicine	medicine	NOUN
dti-1416	244	19	.	.	PUNCT
dti-1416	245	1	pharmacol	pharmacol	PROPN
dti-1416	245	2	rev	rev	PROPN
dti-1416	245	3	.	.	PUNCT
dti-1416	246	1	2013;65(3):987	2013;65(3):987	NUM
dti-1416	246	2	-	-	PUNCT
dti-1416	246	3	1009	1009	NUM
dti-1416	246	4	.	.	PUNCT
dti-1416	247	1	13	13	NUM
dti-1416	247	2	.	.	X
dti-1416	248	1	us	us	PROPN
dti-1416	248	2	food	food	NOUN
dti-1416	248	3	and	and	CCONJ
dti-1416	248	4	drug	drug	PROPN
dti-1416	248	5	administration	administration	NOUN
dti-1416	248	6	.	.	PUNCT
dti-1416	249	1	table	table	NOUN
dti-1416	249	2	of	of	ADP
dti-1416	249	3	pharmacogenomic	pharmacogenomic	ADJ
dti-1416	249	4	biomarkers	biomarker	NOUN
dti-1416	249	5	in	in	ADP
dti-1416	249	6	drug	drug	NOUN
dti-1416	249	7	labeling	labeling	NOUN
dti-1416	249	8	:	:	PUNCT
dti-1416	249	9	clopidogrel	clopidogrel	NOUN
dti-1416	249	10	.	.	PUNCT
dti-1416	250	1	https://www.fda.gov/drugs/science-research-drugs/	https://www.fda.gov/drugs/science-research-drugs/	ADP
dti-1416	250	2	table	table	NOUN
dti-1416	250	3	-	-	PUNCT
dti-1416	250	4	pharmacogenomic	pharmacogenomic	ADJ
dti-1416	250	5	-	-	PUNCT
dti-1416	250	6	biomarkers	biomarker	NOUN
dti-1416	250	7	-	-	PUNCT
dti-1416	250	8	drug	drug	NOUN
dti-1416	250	9	-	-	PUNCT
dti-1416	250	10	labeling	labeling	NOUN
dti-1416	250	11	.	.	PUNCT
dti-1416	251	1	updated	update	VERB
dti-1416	251	2	september	september	PROPN
dti-1416	251	3	3	3	NUM
dti-1416	251	4	,	,	PUNCT
dti-1416	251	5	2019	2019	NUM
dti-1416	251	6	.	.	PUNCT
dti-1416	252	1	accessed	access	VERB
dti-1416	252	2	september	september	PROPN
dti-1416	252	3	5	5	NUM
dti-1416	252	4	,	,	PUNCT
dti-1416	252	5	2019	2019	NUM
dti-1416	252	6	.	.	PUNCT
dti-1416	253	1	14	14	NUM
dti-1416	253	2	.	.	PUNCT
dti-1416	254	1	he	he	PRON
dti-1416	254	2	y	y	PROPN
dti-1416	254	3	,	,	PUNCT
dti-1416	254	4	hoskins	hoskins	PROPN
dti-1416	254	5	jm	jm	PROPN
dti-1416	254	6	,	,	PUNCT
dti-1416	254	7	mcleod	mcleod	PROPN
dti-1416	254	8	hl	hl	PROPN
dti-1416	254	9	.	.	PROPN
dti-1416	254	10	copy	copy	NOUN
dti-1416	254	11	number	number	NOUN
dti-1416	254	12	variants	variant	NOUN
dti-1416	254	13	in	in	ADP
dti-1416	254	14	pharmacogenetic	pharmacogenetic	ADJ
dti-1416	254	15	genes	gene	NOUN
dti-1416	254	16	.	.	PUNCT
dti-1416	255	1	trends	trend	NOUN
dti-1416	255	2	mol	mol	ADP
dti-1416	255	3	med	med	PROPN
dti-1416	255	4	.	.	PUNCT
dti-1416	256	1	2011;17:244	2011;17:244	NUM
dti-1416	256	2	-	-	PUNCT
dti-1416	256	3	251	251	NUM
dti-1416	256	4	.	.	PUNCT
dti-1416	257	1	doi:10.1016	doi:10.1016	PROPN
dti-1416	257	2	/	/	SYM
dti-1416	257	3	j.molmed.2011.01.007	j.molmed.2011.01.007	PROPN
dti-1416	257	4	.	.	PROPN
dti-1416	257	5	15	15	NUM
dti-1416	257	6	.	.	PUNCT
dti-1416	258	1	gaedigk	gaedigk	PROPN
dti-1416	258	2	a	a	PRON
dti-1416	258	3	,	,	PUNCT
dti-1416	258	4	ingelman	ingelman	NOUN
dti-1416	258	5	-	-	PUNCT
dti-1416	258	6	sundberg	sundberg	PROPN
dti-1416	258	7	m	m	PROPN
dti-1416	258	8	,	,	PUNCT
dti-1416	258	9	miller	miller	PROPN
dti-1416	258	10	na	na	PROPN
dti-1416	258	11	,	,	PUNCT
dti-1416	258	12	leeder	leeder	PROPN
dti-1416	258	13	js	js	PROPN
dti-1416	258	14	,	,	PUNCT
dti-1416	258	15	whirl	whirl	NOUN
dti-1416	258	16	-	-	PUNCT
dti-1416	258	17	carrillo	carrillo	PROPN
dti-1416	258	18	m	m	PROPN
dti-1416	258	19	,	,	PUNCT
dti-1416	258	20	klein	klein	PROPN
dti-1416	258	21	te	te	PROPN
dti-1416	258	22	.	.	PUNCT
dti-1416	259	1	the	the	DET
dti-1416	259	2	pharmacogene	pharmacogene	NOUN
dti-1416	259	3	variation	variation	NOUN
dti-1416	259	4	(	(	PUNCT
dti-1416	259	5	pharmvar	pharmvar	NOUN
dti-1416	259	6	)	)	PUNCT
dti-1416	259	7	consortium	consortium	NOUN
dti-1416	259	8	:	:	PUNCT
dti-1416	259	9	incorporation	incorporation	NOUN
dti-1416	259	10	of	of	ADP
dti-1416	259	11	the	the	DET
dti-1416	259	12	human	human	ADJ
dti-1416	259	13	cytochrome	cytochrome	NOUN
dti-1416	259	14	p450	p450	PROPN
dti-1416	259	15	(	(	PUNCT
dti-1416	259	16	cyp	cyp	ADJ
dti-1416	259	17	)	)	PUNCT
dti-1416	259	18	allele	allele	NOUN
dti-1416	259	19	nomenclature	nomenclature	NOUN
dti-1416	259	20	database	database	NOUN
dti-1416	259	21	.	.	PUNCT
dti-1416	260	1	clin	clin	PROPN
dti-1416	260	2	pharmacol	pharmacol	PROPN
dti-1416	260	3	ther	ther	ADV
dti-1416	260	4	.	.	PUNCT
dti-1416	261	1	2018;103(3):399	2018;103(3):399	NUM
dti-1416	261	2	-	-	SYM
dti-1416	261	3	401	401	NUM
dti-1416	261	4	.	.	PUNCT
dti-1416	262	1	16	16	NUM
dti-1416	262	2	.	.	PUNCT
dti-1416	263	1	pharmacogene	pharmacogene	NOUN
dti-1416	263	2	variation	variation	NOUN
dti-1416	263	3	consortium	consortium	NOUN
dti-1416	263	4	(	(	PUNCT
dti-1416	263	5	pharmvar	pharmvar	NOUN
dti-1416	263	6	)	)	PUNCT
dti-1416	263	7	.	.	PUNCT
dti-1416	264	1	genes	gene	NOUN
dti-1416	264	2	.	.	PUNCT
dti-1416	265	1	https://www.pharmvar.org/genes	https://www.pharmvar.org/genes	PROPN
dti-1416	265	2	.	.	PUNCT
dti-1416	266	1	updated	update	VERB
dti-1416	266	2	june	june	PROPN
dti-1416	266	3	21	21	NUM
dti-1416	266	4	,	,	PUNCT
dti-1416	266	5	2019	2019	NUM
dti-1416	266	6	.	.	PUNCT
dti-1416	267	1	accessed	access	VERB
dti-1416	267	2	july	july	PROPN
dti-1416	267	3	3	3	NUM
dti-1416	267	4	,	,	PUNCT
dti-1416	267	5	2019	2019	NUM
dti-1416	267	6	.	.	PUNCT
dti-1416	268	1	17	17	NUM
dti-1416	268	2	.	.	PUNCT
dti-1416	269	1	zhou	zhou	PROPN
dti-1416	269	2	sf	sf	PROPN
dti-1416	269	3	.	.	PUNCT
dti-1416	269	4	polymorphism	polymorphism	NOUN
dti-1416	269	5	of	of	ADP
dti-1416	269	6	human	human	ADJ
dti-1416	269	7	cytochrome	cytochrome	NOUN
dti-1416	269	8	p450	p450	PROPN
dti-1416	269	9	2d6	2d6	NUM
dti-1416	269	10	and	and	CCONJ
dti-1416	269	11	its	its	PRON
dti-1416	269	12	clinical	clinical	ADJ
dti-1416	269	13	significance	significance	NOUN
dti-1416	269	14	:	:	PUNCT
dti-1416	269	15	part	part	NOUN
dti-1416	269	16	i.	i.	PROPN
dti-1416	269	17	clin	clin	PROPN
dti-1416	269	18	pharmacokinet	pharmacokinet	PROPN
dti-1416	269	19	.	.	PUNCT
dti-1416	270	1	2009;48:689	2009;48:689	NUM
dti-1416	270	2	-	-	SYM
dti-1416	270	3	723	723	NUM
dti-1416	270	4	.	.	NOUN
dti-1416	271	1	18	18	NUM
dti-1416	271	2	.	.	PUNCT
dti-1416	272	1	dean	dean	PROPN
dti-1416	272	2	l.	l.	PROPN
dti-1416	272	3	codeine	codeine	PROPN
dti-1416	272	4	therapy	therapy	NOUN
dti-1416	272	5	and	and	CCONJ
dti-1416	272	6	cyp2d6	cyp2d6	NOUN
dti-1416	272	7	genotype	genotype	NOUN
dti-1416	272	8	.	.	PUNCT
dti-1416	273	1	in	in	ADP
dti-1416	273	2	:	:	PUNCT
dti-1416	273	3	medical	medical	ADJ
dti-1416	273	4	genetics	genetics	NOUN
dti-1416	273	5	summaries	summary	NOUN
dti-1416	273	6	.	.	PUNCT
dti-1416	274	1	https://www.ncbi.nlm.nih.gov/books/nbk100662/.	https://www.ncbi.nlm.nih.gov/books/nbk100662/.	PROPN
dti-1416	274	2	updated	update	VERB
dti-1416	274	3	march	march	PROPN
dti-1416	274	4	16	16	NUM
dti-1416	274	5	,	,	PUNCT
dti-1416	274	6	2017	2017	NUM
dti-1416	274	7	.	.	PUNCT
dti-1416	275	1	accessed	access	VERB
dti-1416	275	2	september	september	PROPN
dti-1416	275	3	4	4	NUM
dti-1416	275	4	,	,	PUNCT
dti-1416	275	5	2019	2019	NUM
dti-1416	275	6	.	.	PUNCT
dti-1416	276	1	19	19	NUM
dti-1416	276	2	.	.	X
dti-1416	276	3	beoris	beoris	PROPN
dti-1416	276	4	m	m	PROPN
dti-1416	276	5	,	,	PUNCT
dti-1416	276	6	amos	amos	PROPN
dti-1416	276	7	wilson	wilson	PROPN
dti-1416	276	8	j	j	PROPN
dti-1416	276	9	,	,	PUNCT
dti-1416	276	10	garces	garces	PROPN
dti-1416	276	11	ja	ja	PROPN
dti-1416	276	12	,	,	PUNCT
dti-1416	276	13	lukowiak	lukowiak	PROPN
dti-1416	276	14	aa	aa	PROPN
dti-1416	276	15	.	.	PUNCT
dti-1416	277	1	cyp2d6	cyp2d6	NOUN
dti-1416	277	2	copy	copy	VERB
dti-1416	277	3	number	number	NOUN
dti-1416	277	4	distribution	distribution	NOUN
dti-1416	277	5	in	in	ADP
dti-1416	277	6	the	the	DET
dti-1416	277	7	us	us	PROPN
dti-1416	277	8	population	population	NOUN
dti-1416	277	9	.	.	PUNCT
dti-1416	278	1	pharmacogenet	pharmacogenet	NOUN
dti-1416	278	2	genomics	genomic	NOUN
dti-1416	278	3	.	.	PUNCT
dti-1416	279	1	2016;26(2):96	2016;26(2):96	NUM
dti-1416	279	2	-	-	SYM
dti-1416	279	3	99	99	NUM
dti-1416	279	4	.	.	PUNCT
dti-1416	280	1	20	20	NUM
dti-1416	280	2	.	.	PUNCT
dti-1416	281	1	the	the	DET
dti-1416	281	2	medical	medical	ADJ
dti-1416	281	3	letter	letter	NOUN
dti-1416	281	4	.	.	PUNCT
dti-1416	282	1	fda	fda	PROPN
dti-1416	282	2	warns	warn	VERB
dti-1416	282	3	against	against	ADP
dti-1416	282	4	use	use	NOUN
dti-1416	282	5	of	of	ADP
dti-1416	282	6	codeine	codeine	NOUN
dti-1416	282	7	and	and	CCONJ
dti-1416	282	8	tramadol	tramadol	NOUN
dti-1416	282	9	in	in	ADP
dti-1416	282	10	children	child	NOUN
dti-1416	282	11	and	and	CCONJ
dti-1416	282	12	breastfeeding	breastfeed	VERB
dti-1416	282	13	women	woman	NOUN
dti-1416	282	14	.	.	PUNCT
dti-1416	283	1	med	med	ADJ
dti-1416	283	2	lett	lett	PROPN
dti-1416	283	3	drugs	drug	NOUN
dti-1416	283	4	ther	ther	ADV
dti-1416	283	5	.	.	PUNCT
dti-1416	284	1	2017;59(1521):86	2017;59(1521):86	NUM
dti-1416	284	2	-	-	SYM
dti-1416	284	3	88	88	NUM
dti-1416	284	4	.	.	PUNCT
dti-1416	285	1	21	21	NUM
dti-1416	285	2	.	.	PUNCT
dti-1416	286	1	pharmacogene	pharmacogene	NOUN
dti-1416	286	2	variation	variation	NOUN
dti-1416	286	3	consortium	consortium	NOUN
dti-1416	286	4	(	(	PUNCT
dti-1416	286	5	pharmvar	pharmvar	NOUN
dti-1416	286	6	)	)	PUNCT
dti-1416	286	7	.	.	PUNCT
dti-1416	287	1	cyp2d6	cyp2d6	NOUN
dti-1416	287	2	.	.	PUNCT
dti-1416	288	1	https://www	https://www	PROPN
dti-1416	288	2	.	.	PUNCT
dti-1416	289	1	pharmvar.org/gene/cyp2d6	pharmvar.org/gene/cyp2d6	NUM
dti-1416	289	2	.	.	PUNCT
dti-1416	290	1	updated	update	VERB
dti-1416	290	2	august	august	PROPN
dti-1416	290	3	28	28	NUM
dti-1416	290	4	,	,	PUNCT
dti-1416	290	5	2019	2019	NUM
dti-1416	290	6	.	.	PUNCT
dti-1416	291	1	accessed	access	VERB
dti-1416	291	2	september	september	PROPN
dti-1416	291	3	4	4	NUM
dti-1416	291	4	,	,	PUNCT
dti-1416	291	5	2019	2019	NUM
dti-1416	291	6	.	.	PUNCT
dti-1416	292	1	22	22	NUM
dti-1416	292	2	.	.	PUNCT
dti-1416	293	1	the	the	DET
dti-1416	293	2	pharmacogenomics	pharmacogenomics	PROPN
dti-1416	293	3	knowledge	knowledge	NOUN
dti-1416	293	4	base	base	PROPN
dti-1416	293	5	(	(	PUNCT
dti-1416	293	6	pharmgkb	pharmgkb	ADJ
dti-1416	293	7	)	)	PUNCT
dti-1416	293	8	.	.	PUNCT
dti-1416	294	1	about	about	ADP
dti-1416	294	2	us	we	PRON
dti-1416	294	3	.	.	PUNCT
dti-1416	295	1	https://www	https://www	PROPN
dti-1416	295	2	.	.	PUNCT
dti-1416	295	3	pharmgkb.org/about	pharmgkb.org/about	NOUN
dti-1416	295	4	.	.	PUNCT
dti-1416	296	1	accessed	access	VERB
dti-1416	296	2	september	september	PROPN
dti-1416	296	3	4	4	NUM
dti-1416	296	4	,	,	PUNCT
dti-1416	296	5	2019	2019	NUM
dti-1416	296	6	.	.	PUNCT
dti-1416	297	1	23	23	NUM
dti-1416	297	2	.	.	PUNCT
dti-1416	298	1	the	the	DET
dti-1416	298	2	pharmacogenomics	pharmacogenomics	PROPN
dti-1416	298	3	knowledge	knowledge	NOUN
dti-1416	298	4	base	base	PROPN
dti-1416	298	5	(	(	PUNCT
dti-1416	298	6	pharmgkb	pharmgkb	ADJ
dti-1416	298	7	)	)	PUNCT
dti-1416	298	8	.	.	PUNCT
dti-1416	299	1	dosing	dose	VERB
dti-1416	299	2	guidelines	guideline	NOUN
dti-1416	299	3	.	.	PUNCT
dti-1416	300	1	https://www.pharmgkb.org/guidelines	https://www.pharmgkb.org/guideline	NOUN
dti-1416	300	2	.	.	PUNCT
dti-1416	300	3	accessed	access	VERB
dti-1416	300	4	september	september	PROPN
dti-1416	300	5	4	4	NUM
dti-1416	300	6	,	,	PUNCT
dti-1416	300	7	2019	2019	NUM
dti-1416	300	8	.	.	PUNCT
dti-1416	301	1	24	24	NUM
dti-1416	301	2	.	.	PUNCT
dti-1416	301	3	lee	lee	PROPN
dti-1416	301	4	a.	a.	PROPN
dti-1416	301	5	adverse	adverse	PROPN
dti-1416	301	6	drug	drug	NOUN
dti-1416	301	7	reactions	reaction	NOUN
dti-1416	301	8	.	.	PUNCT
dti-1416	302	1	2nd	2nd	ADJ
dti-1416	302	2	ed	ed	NOUN
dti-1416	302	3	.	.	PUNCT
dti-1416	303	1	london	london	PROPN
dti-1416	303	2	,	,	PUNCT
dti-1416	303	3	england	england	PROPN
dti-1416	303	4	:	:	PUNCT
dti-1416	303	5	pharmaceutical	pharmaceutical	NOUN
dti-1416	303	6	press	press	NOUN
dti-1416	303	7	;	;	PUNCT
dti-1416	303	8	2006:7	2006:7	NUM
dti-1416	303	9	.	.	PUNCT
dti-1416	304	1	25	25	NUM
dti-1416	304	2	.	.	PUNCT
dti-1416	304	3	negrini	negrini	PROPN
dti-1416	304	4	s	s	PROPN
dti-1416	304	5	,	,	PUNCT
dti-1416	304	6	becquemont	becquemont	PROPN
dti-1416	304	7	l.	l.	PROPN
dti-1416	304	8	hla	hla	PROPN
dti-1416	304	9	-	-	PUNCT
dti-1416	304	10	associated	associate	VERB
dti-1416	304	11	drug	drug	NOUN
dti-1416	304	12	hypersensitivity	hypersensitivity	NOUN
dti-1416	304	13	and	and	CCONJ
dti-1416	304	14	the	the	DET
dti-1416	304	15	prediction	prediction	NOUN
dti-1416	304	16	of	of	ADP
dti-1416	304	17	adverse	adverse	ADJ
dti-1416	304	18	drug	drug	NOUN
dti-1416	304	19	reactions	reaction	NOUN
dti-1416	304	20	.	.	PUNCT
dti-1416	305	1	pharmacogenomics	pharmacogenomic	NOUN
dti-1416	305	2	.	.	PUNCT
dti-1416	306	1	2017;18:1441	2017;18:1441	NUM
dti-1416	306	2	-	-	SYM
dti-1416	306	3	1457	1457	NUM
dti-1416	306	4	.	.	PUNCT
dti-1416	307	1	doi:10.2217	doi:10.2217	NOUN
dti-1416	307	2	/	/	SYM
dti-1416	307	3	pgs-2017	pgs-2017	NOUN
dti-1416	307	4	-	-	PUNCT
dti-1416	307	5	0090	0090	NUM
dti-1416	307	6	.	.	PUNCT
dti-1416	308	1	26	26	NUM
dti-1416	308	2	.	.	PUNCT
dti-1416	309	1	clinical	clinical	ADJ
dti-1416	309	2	pharmacogenetics	pharmacogenetic	NOUN
dti-1416	309	3	implementation	implementation	NOUN
dti-1416	309	4	consortium	consortium	PROPN
dti-1416	309	5	(	(	PUNCT
dti-1416	309	6	cpic	cpic	NOUN
dti-1416	309	7	)	)	PUNCT
dti-1416	309	8	.	.	PUNCT
dti-1416	310	1	guidelines	guideline	NOUN
dti-1416	310	2	.	.	PUNCT
dti-1416	311	1	https://cpicpgx.org/guidelines/.	https://cpicpgx.org/guidelines/.	PROPN
dti-1416	311	2	updated	update	VERB
dti-1416	311	3	july	july	PROPN
dti-1416	311	4	11	11	NUM
dti-1416	311	5	,	,	PUNCT
dti-1416	311	6	2019	2019	NUM
dti-1416	311	7	.	.	PUNCT
dti-1416	312	1	accessed	access	VERB
dti-1416	312	2	september	september	PROPN
dti-1416	312	3	5	5	NUM
dti-1416	312	4	,	,	PUNCT
dti-1416	312	5	2019	2019	NUM
dti-1416	312	6	.	.	PUNCT
dti-1416	313	1	27	27	NUM
dti-1416	313	2	.	.	PUNCT
dti-1416	313	3	negrini	negrini	PROPN
dti-1416	313	4	s	s	PART
dti-1416	313	5	,	,	PUNCT
dti-1416	313	6	becquemont	becquemont	PROPN
dti-1416	313	7	l.	l.	PROPN
dti-1416	313	8	pharmacogenetics	pharmacogenetics	PROPN
dti-1416	313	9	of	of	ADP
dti-1416	313	10	hypersensitivity	hypersensitivity	NOUN
dti-1416	313	11	drug	drug	NOUN
dti-1416	313	12	reactions	reaction	NOUN
dti-1416	313	13	.	.	PUNCT
dti-1416	314	1	therapie	therapie	PROPN
dti-1416	314	2	.	.	PUNCT
dti-1416	315	1	2017;72:231	2017;72:231	PROPN
dti-1416	315	2	-	-	SYM
dti-1416	315	3	243	243	NUM
dti-1416	315	4	.	.	PUNCT
dti-1416	316	1	28	28	NUM
dti-1416	316	2	.	.	PUNCT
dti-1416	317	1	us	us	PROPN
dti-1416	317	2	food	food	NOUN
dti-1416	317	3	and	and	CCONJ
dti-1416	317	4	drug	drug	PROPN
dti-1416	317	5	administration	administration	NOUN
dti-1416	317	6	.	.	PUNCT
dti-1416	318	1	table	table	NOUN
dti-1416	318	2	of	of	ADP
dti-1416	318	3	pharmacogenomic	pharmacogenomic	ADJ
dti-1416	318	4	biomarkers	biomarker	NOUN
dti-1416	318	5	in	in	ADP
dti-1416	318	6	drug	drug	NOUN
dti-1416	318	7	labeling	labeling	NOUN
dti-1416	318	8	:	:	PUNCT
dti-1416	318	9	carbamazepine	carbamazepine	NOUN
dti-1416	318	10	.	.	PUNCT
dti-1416	319	1	https://www.fda.gov/drugs/science-researchdrugs/table-pharmacogenomic-biomarkers-drug-labeling	https://www.fda.gov/drugs/science-researchdrugs/table-pharmacogenomic-biomarkers-drug-labele	VERB
dti-1416	319	2	.	.	PUNCT
dti-1416	320	1	updated	update	VERB
dti-1416	320	2	september	september	PROPN
dti-1416	320	3	3	3	NUM
dti-1416	320	4	,	,	PUNCT
dti-1416	320	5	2019	2019	NUM
dti-1416	320	6	.	.	PUNCT
dti-1416	321	1	accessed	access	VERB
dti-1416	321	2	september	september	PROPN
dti-1416	321	3	5	5	NUM
dti-1416	321	4	,	,	PUNCT
dti-1416	321	5	2019	2019	NUM
dti-1416	321	6	.	.	PUNCT
dti-1416	322	1	29	29	NUM
dti-1416	322	2	.	.	PUNCT
dti-1416	323	1	the	the	DET
dti-1416	323	2	pharmacogenomics	pharmacogenomics	PROPN
dti-1416	323	3	knowledge	knowledge	NOUN
dti-1416	323	4	base	base	PROPN
dti-1416	323	5	(	(	PUNCT
dti-1416	323	6	pharmgkb	pharmgkb	ADJ
dti-1416	323	7	)	)	PUNCT
dti-1416	323	8	.	.	PUNCT
dti-1416	324	1	annotation	annotation	NOUN
dti-1416	324	2	of	of	ADP
dti-1416	324	3	cpic	cpic	PROPN
dti-1416	324	4	guideline	guideline	NOUN
dti-1416	324	5	for	for	ADP
dti-1416	324	6	carbamazepine	carbamazepine	NOUN
dti-1416	324	7	and	and	CCONJ
dti-1416	324	8	hla	hla	PROPN
dti-1416	324	9	-	-	PUNCT
dti-1416	324	10	a	a	PRON
dti-1416	324	11	,	,	PUNCT
dti-1416	324	12	hla	hla	PROPN
dti-1416	324	13	-	-	PUNCT
dti-1416	324	14	b.	b.	PROPN
dti-1416	324	15	https://www.pharmgkb	https://www.pharmgkb	X
dti-1416	324	16	.	.	PUNCT
dti-1416	325	1	org	org	ADJ
dti-1416	325	2	/	/	SYM
dti-1416	325	3	guideline	guideline	NOUN
dti-1416	325	4	/	/	SYM
dti-1416	325	5	pa166105008	pa166105008	NOUN
dti-1416	325	6	.	.	PUNCT
dti-1416	326	1	updated	update	VERB
dti-1416	326	2	march	march	PROPN
dti-1416	326	3	20	20	NUM
dti-1416	326	4	,	,	PUNCT
dti-1416	326	5	2019	2019	NUM
dti-1416	326	6	.	.	PUNCT
dti-1416	327	1	accessed	access	VERB
dti-1416	327	2	september	september	PROPN
dti-1416	327	3	4	4	NUM
dti-1416	327	4	,	,	PUNCT
dti-1416	327	5	2019	2019	NUM
dti-1416	327	6	.	.	PUNCT
dti-1416	328	1	30	30	NUM
dti-1416	328	2	.	.	PUNCT
dti-1416	329	1	national	national	ADJ
dti-1416	329	2	human	human	PROPN
dti-1416	329	3	genome	genome	PROPN
dti-1416	329	4	research	research	NOUN
dti-1416	329	5	institute	institute	NOUN
dti-1416	329	6	.	.	PUNCT
dti-1416	330	1	the	the	DET
dti-1416	330	2	cost	cost	NOUN
dti-1416	330	3	of	of	ADP
dti-1416	330	4	sequencing	sequence	VERB
dti-1416	330	5	a	a	DET
dti-1416	330	6	human	human	ADJ
dti-1416	330	7	genome	genome	NOUN
dti-1416	330	8	.	.	PUNCT
dti-1416	331	1	https://www.genome.gov/about-genomics/fact-sheets/sequencing	https://www.genome.gov/about-genomics/fact-sheets/sequence	VERB
dti-1416	331	2	-human	-human	ADJ
dti-1416	331	3	-	-	PUNCT
dti-1416	331	4	genome	genome	NOUN
dti-1416	331	5	-	-	PUNCT
dti-1416	331	6	cost	cost	NOUN
dti-1416	331	7	.	.	PUNCT
dti-1416	332	1	updated	update	VERB
dti-1416	332	2	july	july	PROPN
dti-1416	332	3	10	10	NUM
dti-1416	332	4	,	,	PUNCT
dti-1416	332	5	2019	2019	NUM
dti-1416	332	6	.	.	PUNCT
dti-1416	333	1	accessed	access	VERB
dti-1416	333	2	september	september	PROPN
dti-1416	333	3	5	5	NUM
dti-1416	333	4	,	,	PUNCT
dti-1416	333	5	2019	2019	NUM
dti-1416	333	6	.	.	PUNCT
dti-1416	334	1	31	31	NUM
dti-1416	334	2	.	.	PUNCT
dti-1416	335	1	reuter	reuter	PROPN
dti-1416	335	2	ja	ja	PROPN
dti-1416	335	3	,	,	PUNCT
dti-1416	335	4	spacek	spacek	PROPN
dti-1416	335	5	d	d	PROPN
dti-1416	335	6	,	,	PUNCT
dti-1416	335	7	snyder	snyder	PROPN
dti-1416	335	8	mp	mp	PROPN
dti-1416	335	9	.	.	PROPN
dti-1416	335	10	high	high	ADJ
dti-1416	335	11	-	-	PUNCT
dti-1416	335	12	throughput	throughput	NOUN
dti-1416	335	13	sequencing	sequence	VERB
dti-1416	335	14	technologies	technology	NOUN
dti-1416	335	15	.	.	PUNCT
dti-1416	336	1	mol	mol	ADP
dti-1416	336	2	cell	cell	NOUN
dti-1416	336	3	.	.	PUNCT
dti-1416	337	1	2015;58:586	2015;58:586	NUM
dti-1416	337	2	-	-	SYM
dti-1416	337	3	597	597	NUM
dti-1416	337	4	.	.	PUNCT
dti-1416	338	1	32	32	NUM
dti-1416	338	2	.	.	PUNCT
dti-1416	339	1	genetics	genetic	NOUN
dti-1416	339	2	home	home	NOUN
dti-1416	339	3	reference	reference	NOUN
dti-1416	339	4	.	.	PUNCT
dti-1416	340	1	what	what	PRON
dti-1416	340	2	is	be	AUX
dti-1416	340	3	direct	direct	ADJ
dti-1416	340	4	-	-	PUNCT
dti-1416	340	5	to	to	ADP
dti-1416	340	6	-	-	PUNCT
dti-1416	340	7	consumer	consumer	NOUN
dti-1416	340	8	genetic	genetic	ADJ
dti-1416	340	9	testing	testing	NOUN
dti-1416	340	10	?	?	PUNCT
dti-1416	341	1	bethesda	bethesda	NOUN
dti-1416	341	2	,	,	PUNCT
dti-1416	341	3	md	md	PROPN
dti-1416	341	4	:	:	PUNCT
dti-1416	341	5	us	us	PROPN
dti-1416	341	6	national	national	PROPN
dti-1416	341	7	library	library	NOUN
dti-1416	341	8	of	of	ADP
dti-1416	341	9	medicine	medicine	NOUN
dti-1416	341	10	.	.	PUNCT
dti-1416	342	1	https://ghr.nlm.nih.gov/	https://ghr.nlm.nih.gov/	NUM
dti-1416	342	2	primer	primer	NOUN
dti-1416	342	3	/	/	SYM
dti-1416	342	4	dtcgenetictesting	dtcgenetictesting	NOUN
dti-1416	342	5	/	/	SYM
dti-1416	342	6	directtoconsumer	directtoconsumer	NOUN
dti-1416	342	7	.	.	PUNCT
dti-1416	343	1	updated	update	VERB
dti-1416	343	2	september	september	PROPN
dti-1416	343	3	3	3	NUM
dti-1416	343	4	,	,	PUNCT
dti-1416	343	5	2019	2019	NUM
dti-1416	343	6	.	.	PUNCT
dti-1416	344	1	accessed	access	VERB
dti-1416	344	2	september	september	PROPN
dti-1416	344	3	4	4	NUM
dti-1416	344	4	,	,	PUNCT
dti-1416	344	5	2019	2019	NUM
dti-1416	344	6	.	.	PUNCT
dti-1416	345	1	https://orcid.org/0000-0001-9450-9040	https://orcid.org/0000-0001-9450-9040	PROPN
dti-1416	345	2	https://ghr.nlm.nih.gov/primer/genomicresearch/pharmacogenomics	https://ghr.nlm.nih.gov/primer/genomicresearch/pharmacogenomic	NOUN
dti-1416	345	3	https://ghr.nlm.nih.gov/primer/genomicresearch/pharmacogenomics	https://ghr.nlm.nih.gov/primer/genomicresearch/pharmacogenomic	NOUN
dti-1416	345	4	https://www.genome.gov/human-genome-project	https://www.genome.gov/human-genome-project	PROPN
dti-1416	345	5	https://www.genome.gov/human-genome-project	https://www.genome.gov/human-genome-project	ADJ
dti-1416	345	6	https://hupo.org/human-proteome-project/	https://hupo.org/human-proteome-project/	NOUN
dti-1416	345	7	https://ghr.nlm.nih.gov/primer/basics/dna	https://ghr.nlm.nih.gov/primer/basics/dna	PROPN
dti-1416	345	8	https://www.genome.gov/11006943/human-genome-project-completion-frequently-asked-questions/	https://www.genome.gov/11006943/human-genome-project-completion-frequently-asked-questions/	PROPN
dti-1416	345	9	https://www.genome.gov/11006943/human-genome-project-completion-frequently-asked-questions/	https://www.genome.gov/11006943/human-genome-project-completion-frequently-asked-questions/	PROPN
dti-1416	345	10	https://www.genome.gov/11006943/human-genome-project-completion-frequently-asked-questions/	https://www.genome.gov/11006943/human-genome-project-completion-frequently-asked-questions/	NOUN
dti-1416	345	11	https://ghr.nlm.nih.gov/primer/basics/chromosome	https://ghr.nlm.nih.gov/primer/basics/chromosome	VERB
dti-1416	345	12	https://ghr.nlm.nih.gov/primer/mutationsanddisorders/naming	https://ghr.nlm.nih.gov/primer/mutationsanddisorders/name	VERB
dti-1416	345	13	https://ghr.nlm.nih.gov/primer/mutationsanddisorders/naming	https://ghr.nlm.nih.gov/primer/mutationsanddisorders/name	VERB
dti-1416	345	14	https://www.genome.gov/glossary/	https://www.genome.gov/glossary/	PUNCT
dti-1416	345	15	https://www.genome.gov/glossary/	https://www.genome.gov/glossary/	PUNCT
dti-1416	345	16	https://www.fda.gov/drugs/science-research-drugs/table-pharmacogenomic-biomarkers-drug-labeling	https://www.fda.gov/drugs/science-research-drugs/table-pharmacogenomic-biomarkers-drug-labele	VERB
dti-1416	345	17	https://www.fda.gov/drugs/science-research-drugs/table-pharmacogenomic-biomarkers-drug-labeling	https://www.fda.gov/drugs/science-research-drugs/table-pharmacogenomic-biomarkers-drug-labele	VERB
dti-1416	345	18	https://www.pharmvar.org/genes	https://www.pharmvar.org/gene	NOUN
dti-1416	345	19	https://www.pharmvar.org/genes	https://www.pharmvar.org/gene	NOUN
dti-1416	345	20	https://www.ncbi.nlm.nih.gov/books/nbk100662/	https://www.ncbi.nlm.nih.gov/books/nbk100662/	NOUN
dti-1416	345	21	https://www.pharmvar.org/gene/cyp2d6	https://www.pharmvar.org/gene/cyp2d6	ADV
dti-1416	345	22	https://www.pharmvar.org/gene/cyp2d6	https://www.pharmvar.org/gene/cyp2d6	ADV
dti-1416	345	23	https://www.pharmgkb.org/about	https://www.pharmgkb.org/about	ADP
dti-1416	345	24	https://www.pharmgkb.org/about	https://www.pharmgkb.org/about	X
dti-1416	346	1	https://www.pharmgkb.org/guidelines	https://www.pharmgkb.org/guideline	NOUN
dti-1416	346	2	https://cpicpgx.org/guidelines/	https://cpicpgx.org/guidelines/	VERB
dti-1416	346	3	https://www.fda.gov/drugs/science-research-drugs/table-pharmacogenomic-biomarkers-drug-labeling	https://www.fda.gov/drugs/science-research-drugs/table-pharmacogenomic-biomarkers-drug-labele	VERB
dti-1416	346	4	https://www.fda.gov/drugs/science-research-drugs/table-pharmacogenomic-biomarkers-drug-labeling	https://www.fda.gov/drugs/science-research-drugs/table-pharmacogenomic-biomarkers-drug-labele	VERB
dti-1416	346	5	https://www.pharmgkb.org/guideline/pa166105008	https://www.pharmgkb.org/guideline/pa166105008	PROPN
dti-1416	346	6	https://www.pharmgkb.org/guideline/pa166105008	https://www.pharmgkb.org/guideline/pa166105008	PROPN
dti-1416	346	7	https://www.genome.gov/about-genomics/fact-sheets/sequencing-human-genome-cost	https://www.genome.gov/about-genomics/fact-sheets/sequencing-human-genome-cost	X
dti-1416	346	8	https://www.genome.gov/about-genomics/fact-sheets/sequencing-human-genome-cost	https://www.genome.gov/about-genomics/fact-sheets/sequencing-human-genome-cost	X
dti-1416	346	9	https://ghr.nlm.nih.gov/primer/dtcgenetictesting/directtoconsumer	https://ghr.nlm.nih.gov/primer/dtcgenetictesting/directtoconsumer	ADP
dti-1416	346	10	https://ghr.nlm.nih.gov/primer/dtcgenetictesting/directtoconsumer	https://ghr.nlm.nih.gov/primer/dtcgenetictesting/directtoconsumer	ADP