id sid tid token lemma pos dti-1423 1 1 1drug 1drug NUM dti-1423 1 2 target target NOUN dti-1423 1 3 insights insight NOUN dti-1423 1 4 2016:10 2016:10 NUM dti-1423 1 5 brain brain NOUN dti-1423 1 6 histamine histamine NOUN dti-1423 1 7 n n CCONJ dti-1423 1 8 - - PUNCT dti-1423 1 9 methyltransferase methyltransferase NOUN dti-1423 1 10 as as ADP dti-1423 1 11 a a DET dti-1423 1 12 possible possible ADJ dti-1423 1 13 target target NOUN dti-1423 1 14 of of ADP dti-1423 1 15 treatment treatment NOUN dti-1423 1 16 for for ADP dti-1423 1 17 methamphetamine methamphetamine NOUN dti-1423 1 18 overdose overdose NOUN dti-1423 1 19 junichi junichi PROPN dti-1423 1 20 kitanaka1 kitanaka1 PROPN dti-1423 1 21 , , PUNCT dti-1423 1 22 nobue nobue VERB dti-1423 1 23 kitanaka1 kitanaka1 PROPN dti-1423 1 24 , , PUNCT dti-1423 1 25 f. f. PROPN dti-1423 1 26 scott scott PROPN dti-1423 1 27 hall2 hall2 PROPN dti-1423 1 28 , , PUNCT dti-1423 1 29 george george PROPN dti-1423 1 30 r. r. PROPN dti-1423 1 31 uhl3 uhl3 PROPN dti-1423 1 32 and and CCONJ dti-1423 1 33 motohiko motohiko PROPN dti-1423 1 34 takemura1 takemura1 PROPN dti-1423 2 1 1department 1department NUM dti-1423 2 2 of of ADP dti-1423 2 3 pharmacology pharmacology NOUN dti-1423 2 4 , , PUNCT dti-1423 2 5 hyogo hyogo PROPN dti-1423 2 6 college college NOUN dti-1423 2 7 of of ADP dti-1423 2 8 medicine medicine NOUN dti-1423 2 9 , , PUNCT dti-1423 2 10 hyogo hyogo NOUN dti-1423 2 11 , , PUNCT dti-1423 2 12 japan japan PROPN dti-1423 2 13 . . PUNCT dti-1423 3 1 2department 2department NUM dti-1423 3 2 of of ADP dti-1423 3 3 pharmacology pharmacology NOUN dti-1423 3 4 and and CCONJ dti-1423 3 5 experimental experimental ADJ dti-1423 3 6 therapeutics therapeutic NOUN dti-1423 3 7 , , PUNCT dti-1423 3 8 college college NOUN dti-1423 3 9 of of ADP dti-1423 3 10 pharmacy pharmacy NOUN dti-1423 3 11 and and CCONJ dti-1423 3 12 pharmaceutical pharmaceutical NOUN dti-1423 3 13 sciences science NOUN dti-1423 3 14 , , PUNCT dti-1423 3 15 university university PROPN dti-1423 3 16 of of ADP dti-1423 3 17 toledo toledo PROPN dti-1423 3 18 , , PUNCT dti-1423 3 19 toledo toledo PROPN dti-1423 3 20 , , PUNCT dti-1423 3 21 oh oh INTJ dti-1423 3 22 , , PUNCT dti-1423 3 23 usa usa PROPN dti-1423 3 24 . . PROPN dti-1423 4 1 3new 3new PROPN dti-1423 4 2 mexico mexico PROPN dti-1423 4 3 va va PROPN dti-1423 4 4 healthcare healthcare PROPN dti-1423 4 5 system system PROPN dti-1423 4 6 / / SYM dti-1423 4 7 brinm brinm PROPN dti-1423 4 8 , , PUNCT dti-1423 4 9 albuquerque albuquerque PROPN dti-1423 4 10 , , PUNCT dti-1423 4 11 nm nm PROPN dti-1423 4 12 , , PUNCT dti-1423 4 13 usa usa PROPN dti-1423 4 14 . . PROPN dti-1423 4 15 abstr abstr PROPN dti-1423 4 16 act act PROPN dti-1423 4 17 : : PUNCT dti-1423 4 18 stereotypical stereotypical ADJ dti-1423 4 19 behaviors behavior NOUN dti-1423 4 20 induced induce VERB dti-1423 4 21 by by ADP dti-1423 4 22 methamphetamine methamphetamine NOUN dti-1423 4 23 ( ( PUNCT dti-1423 4 24 meth meth NOUN dti-1423 4 25 ) ) PUNCT dti-1423 4 26 overdose overdose NOUN dti-1423 4 27 are be AUX dti-1423 4 28 one one NUM dti-1423 4 29 of of ADP dti-1423 4 30 the the DET dti-1423 4 31 overt overt ADJ dti-1423 4 32 symptoms symptom NOUN dti-1423 4 33 of of ADP dti-1423 4 34 meth meth NOUN dti-1423 4 35 abuse abuse NOUN dti-1423 4 36 , , PUNCT dti-1423 4 37 which which PRON dti-1423 4 38 can can AUX dti-1423 4 39 be be AUX dti-1423 4 40 easily easily ADV dti-1423 4 41 assessed assess VERB dti-1423 4 42 in in ADP dti-1423 4 43 animal animal NOUN dti-1423 4 44 models model NOUN dti-1423 4 45 . . PUNCT dti-1423 5 1 currently currently ADV dti-1423 5 2 , , PUNCT dti-1423 5 3 there there PRON dti-1423 5 4 is be VERB dti-1423 5 5 no no DET dti-1423 5 6 successful successful ADJ dti-1423 5 7 treatment treatment NOUN dti-1423 5 8 for for ADP dti-1423 5 9 meth meth NOUN dti-1423 5 10 overdose overdose ADV dti-1423 5 11 . . PUNCT dti-1423 6 1 there there PRON dti-1423 6 2 is be VERB dti-1423 6 3 increasing increase VERB dti-1423 6 4 evidence evidence NOUN dti-1423 6 5 that that SCONJ dti-1423 6 6 elevated elevated ADJ dti-1423 6 7 levels level NOUN dti-1423 6 8 of of ADP dti-1423 6 9 brain brain NOUN dti-1423 6 10 histamine histamine NOUN dti-1423 6 11 can can AUX dti-1423 6 12 attenuate attenuate VERB dti-1423 6 13 meth meth NOUN dti-1423 6 14 - - PUNCT dti-1423 6 15 induced induce VERB dti-1423 6 16 behavioral behavioral ADJ dti-1423 6 17 abnormalities abnormality NOUN dti-1423 6 18 , , PUNCT dti-1423 6 19 which which PRON dti-1423 6 20 might might AUX dti-1423 6 21 therefore therefore ADV dti-1423 6 22 constitute constitute VERB dti-1423 6 23 a a DET dti-1423 6 24 novel novel ADJ dti-1423 6 25 therapeutic therapeutic ADJ dti-1423 6 26 treatment treatment NOUN dti-1423 6 27 for for ADP dti-1423 6 28 meth meth NOUN dti-1423 6 29 abuse abuse NOUN dti-1423 6 30 and and CCONJ dti-1423 6 31 meth meth NOUN dti-1423 6 32 overdose overdose ADV dti-1423 6 33 . . PUNCT dti-1423 7 1 in in ADP dti-1423 7 2 mammals mammal NOUN dti-1423 7 3 , , PUNCT dti-1423 7 4 histamine histamine NOUN dti-1423 7 5 n n CCONJ dti-1423 7 6 - - PUNCT dti-1423 7 7 methyltransferase methyltransferase NOUN dti-1423 7 8 ( ( PUNCT dti-1423 7 9 hmt hmt NOUN dti-1423 7 10 ) ) PUNCT dti-1423 7 11 is be AUX dti-1423 7 12 the the DET dti-1423 7 13 sole sole ADJ dti-1423 7 14 enzyme enzyme NOUN dti-1423 7 15 responsible responsible ADJ dti-1423 7 16 for for ADP dti-1423 7 17 degrading degrade VERB dti-1423 7 18 histamine histamine NOUN dti-1423 7 19 in in ADP dti-1423 7 20 the the DET dti-1423 7 21 brain brain NOUN dti-1423 7 22 . . PUNCT dti-1423 8 1 metoprine metoprine NOUN dti-1423 8 2 , , PUNCT dti-1423 8 3 one one NUM dti-1423 8 4 of of ADP dti-1423 8 5 the the DET dti-1423 8 6 most most ADV dti-1423 8 7 potent potent ADJ dti-1423 8 8 hmt hmt NOUN dti-1423 8 9 inhibitors inhibitor NOUN dti-1423 8 10 , , PUNCT dti-1423 8 11 can can AUX dti-1423 8 12 cross cross VERB dti-1423 8 13 the the DET dti-1423 8 14 blood blood NOUN dti-1423 8 15 – – PUNCT dti-1423 8 16 brain brain NOUN dti-1423 8 17 barrier barrier NOUN dti-1423 8 18 and and CCONJ dti-1423 8 19 increase increase VERB dti-1423 8 20 brain brain NOUN dti-1423 8 21 histamine histamine NOUN dti-1423 8 22 levels level NOUN dti-1423 8 23 by by ADP dti-1423 8 24 inhibiting inhibit VERB dti-1423 8 25 hmt hmt NOUN dti-1423 8 26 . . PUNCT dti-1423 9 1 consequently consequently ADV dti-1423 9 2 , , PUNCT dti-1423 9 3 this this DET dti-1423 9 4 compound compound NOUN dti-1423 9 5 can can AUX dti-1423 9 6 be be AUX dti-1423 9 7 a a DET dti-1423 9 8 candidate candidate NOUN dti-1423 9 9 for for ADP dti-1423 9 10 a a DET dti-1423 9 11 prototype prototype NOUN dti-1423 9 12 of of ADP dti-1423 9 13 drugs drug NOUN dti-1423 9 14 for for ADP dti-1423 9 15 the the DET dti-1423 9 16 treatment treatment NOUN dti-1423 9 17 of of ADP dti-1423 9 18 meth meth NOUN dti-1423 9 19 overdose overdose NOUN dti-1423 9 20 . . PUNCT dti-1423 10 1 key key ADJ dti-1423 10 2 words word NOUN dti-1423 10 3 : : PUNCT dti-1423 10 4 methamphetamine methamphetamine NOUN dti-1423 10 5 , , PUNCT dti-1423 10 6 overdose overdose ADV dti-1423 10 7 , , PUNCT dti-1423 10 8 stereotyped stereotyped ADJ dti-1423 10 9 behavior behavior NOUN dti-1423 10 10 , , PUNCT dti-1423 10 11 histamine histamine NOUN dti-1423 10 12 n n CCONJ dti-1423 10 13 - - PUNCT dti-1423 10 14 methyltransferase methyltransferase NOUN dti-1423 10 15 , , PUNCT dti-1423 10 16 brain brain NOUN dti-1423 10 17 histaminergic histaminergic ADJ dti-1423 10 18 system system NOUN dti-1423 10 19 , , PUNCT dti-1423 10 20 metoprine metoprine NOUN dti-1423 10 21 citation citation NOUN dti-1423 10 22 : : PUNCT dti-1423 10 23 kitanaka kitanaka PROPN dti-1423 10 24 et et PROPN dti-1423 10 25 al al PROPN dti-1423 10 26 . . PROPN dti-1423 10 27 brain brain PROPN dti-1423 10 28 histamine histamine NOUN dti-1423 10 29 n n CCONJ dti-1423 10 30 - - PUNCT dti-1423 10 31 methyltransferase methyltransferase NOUN dti-1423 10 32 as as ADP dti-1423 10 33 a a DET dti-1423 10 34 possible possible ADJ dti-1423 10 35 target target NOUN dti-1423 10 36 of of ADP dti-1423 10 37 treatment treatment NOUN dti-1423 10 38 for for ADP dti-1423 10 39 methamphetamine methamphetamine NOUN dti-1423 10 40 overdose overdose NOUN dti-1423 10 41 . . PUNCT dti-1423 11 1 drug drug NOUN dti-1423 11 2 target target NOUN dti-1423 11 3 insights insight NOUN dti-1423 11 4 2016:10 2016:10 NUM dti-1423 11 5 1–7 1–7 NUM dti-1423 11 6 doi:10.4137 doi:10.4137 NOUN dti-1423 11 7 / / SYM dti-1423 11 8 dti.s38342 dti.s38342 NOUN dti-1423 11 9 . . PUNCT dti-1423 12 1 type type NOUN dti-1423 12 2 : : PUNCT dti-1423 12 3 review review NOUN dti-1423 12 4 received receive VERB dti-1423 12 5 : : PUNCT dti-1423 12 6 december december PROPN dti-1423 12 7 23 23 NUM dti-1423 12 8 , , PUNCT dti-1423 12 9 2015 2015 NUM dti-1423 12 10 . . PUNCT dti-1423 13 1 resubmitted resubmitte VERB dti-1423 13 2 : : PUNCT dti-1423 13 3 january january PROPN dti-1423 13 4 25 25 NUM dti-1423 13 5 , , PUNCT dti-1423 13 6 2016 2016 NUM dti-1423 13 7 . . PUNCT dti-1423 14 1 accepted accept VERB dti-1423 14 2 for for ADP dti-1423 14 3 publication publication NOUN dti-1423 14 4 : : PUNCT dti-1423 14 5 january january PROPN dti-1423 14 6 27 27 NUM dti-1423 14 7 , , PUNCT dti-1423 14 8 2016 2016 NUM dti-1423 14 9 . . PUNCT dti-1423 15 1 academic academic ADJ dti-1423 15 2 editor editor NOUN dti-1423 15 3 : : PUNCT dti-1423 15 4 anuj anuj PROPN dti-1423 15 5 chauhan chauhan PROPN dti-1423 15 6 , , PUNCT dti-1423 15 7 editor editor NOUN dti-1423 15 8 in in ADP dti-1423 15 9 chief chief ADJ dti-1423 15 10 peer peer NOUN dti-1423 15 11 review review NOUN dti-1423 15 12 : : PUNCT dti-1423 15 13 four four NUM dti-1423 15 14 peer peer NOUN dti-1423 15 15 reviewers reviewer NOUN dti-1423 15 16 contributed contribute VERB dti-1423 15 17 to to ADP dti-1423 15 18 the the DET dti-1423 15 19 peer peer NOUN dti-1423 15 20 review review NOUN dti-1423 15 21 report report NOUN dti-1423 15 22 . . PUNCT dti-1423 16 1 reviewers reviewer NOUN dti-1423 16 2 ’ ' PUNCT dti-1423 16 3 reports report NOUN dti-1423 16 4 totaled total VERB dti-1423 16 5 341 341 NUM dti-1423 16 6 words word NOUN dti-1423 16 7 , , PUNCT dti-1423 16 8 excluding exclude VERB dti-1423 16 9 any any DET dti-1423 16 10 confidential confidential ADJ dti-1423 16 11 comments comment NOUN dti-1423 16 12 to to ADP dti-1423 16 13 the the DET dti-1423 16 14 academic academic ADJ dti-1423 16 15 editor editor NOUN dti-1423 16 16 . . PUNCT dti-1423 17 1 funding funding NOUN dti-1423 17 2 : : PUNCT dti-1423 17 3 this this DET dti-1423 17 4 research research NOUN dti-1423 17 5 was be AUX dti-1423 17 6 supported support VERB dti-1423 17 7 , , PUNCT dti-1423 17 8 in in ADP dti-1423 17 9 part part NOUN dti-1423 17 10 , , PUNCT dti-1423 17 11 by by ADP dti-1423 17 12 a a DET dti-1423 17 13 grant grant NOUN dti-1423 17 14 - - PUNCT dti-1423 17 15 in in ADP dti-1423 17 16 - - PUNCT dti-1423 17 17 aid aid NOUN dti-1423 17 18 for for ADP dti-1423 17 19 researchers researcher NOUN dti-1423 17 20 , , PUNCT dti-1423 17 21 hyogo hyogo VERB dti-1423 17 22 college college NOUN dti-1423 17 23 of of ADP dti-1423 17 24 medicine medicine NOUN dti-1423 17 25 ( ( PUNCT dti-1423 17 26 2015 2015 NUM dti-1423 17 27 to to ADP dti-1423 17 28 nk nk PROPN dti-1423 17 29 ) ) PUNCT dti-1423 17 30 and and CCONJ dti-1423 17 31 jsps jsps PROPN dti-1423 17 32 kakenhi kakenhi PROPN dti-1423 17 33 grant grant PROPN dti-1423 17 34 number number NOUN dti-1423 17 35 15k08603 15k08603 PROPN dti-1423 17 36 ( ( PUNCT dti-1423 17 37 to to ADP dti-1423 17 38 jk jk PROPN dti-1423 17 39 ) ) PUNCT dti-1423 17 40 . . PUNCT dti-1423 18 1 the the DET dti-1423 18 2 authors author NOUN dti-1423 18 3 confirm confirm VERB dti-1423 18 4 that that SCONJ dti-1423 18 5 the the DET dti-1423 18 6 funder funder NOUN dti-1423 18 7 had have VERB dti-1423 18 8 no no DET dti-1423 18 9 influence influence NOUN dti-1423 18 10 over over ADP dti-1423 18 11 the the DET dti-1423 18 12 study study NOUN dti-1423 18 13 design design NOUN dti-1423 18 14 , , PUNCT dti-1423 18 15 content content NOUN dti-1423 18 16 of of ADP dti-1423 18 17 the the DET dti-1423 18 18 article article NOUN dti-1423 18 19 , , PUNCT dti-1423 18 20 or or CCONJ dti-1423 18 21 selection selection NOUN dti-1423 18 22 of of ADP dti-1423 18 23 this this DET dti-1423 18 24 journal journal NOUN dti-1423 18 25 . . PUNCT dti-1423 19 1 competing compete VERB dti-1423 19 2 interests interest NOUN dti-1423 19 3 : : PUNCT dti-1423 19 4 metoprine metoprine NOUN dti-1423 19 5 was be AUX dti-1423 19 6 donated donate VERB dti-1423 19 7 by by ADP dti-1423 19 8 glaxosmithkline glaxosmithkline PROPN dti-1423 19 9 . . PUNCT dti-1423 20 1 authors author NOUN dti-1423 20 2 disclose disclose VERB dti-1423 20 3 no no DET dti-1423 20 4 other other ADJ dti-1423 20 5 potential potential ADJ dti-1423 20 6 conflicts conflict NOUN dti-1423 20 7 of of ADP dti-1423 20 8 interest interest NOUN dti-1423 20 9 . . PUNCT dti-1423 21 1 copyright copyright NOUN dti-1423 21 2 : : PUNCT dti-1423 21 3 © © PROPN dti-1423 21 4 the the DET dti-1423 21 5 authors author NOUN dti-1423 21 6 , , PUNCT dti-1423 21 7 publisher publisher NOUN dti-1423 21 8 and and CCONJ dti-1423 21 9 licensee licensee NOUN dti-1423 21 10 libertas liberta NOUN dti-1423 21 11 academica academica PROPN dti-1423 21 12 limited limit VERB dti-1423 21 13 . . PUNCT dti-1423 22 1 this this PRON dti-1423 22 2 is be AUX dti-1423 22 3 an an DET dti-1423 22 4 open open ADJ dti-1423 22 5 - - PUNCT dti-1423 22 6 access access NOUN dti-1423 22 7 article article NOUN dti-1423 22 8 distributed distribute VERB dti-1423 22 9 under under ADP dti-1423 22 10 the the DET dti-1423 22 11 terms term NOUN dti-1423 22 12 of of ADP dti-1423 22 13 the the DET dti-1423 22 14 creative creative ADJ dti-1423 22 15 commons common NOUN dti-1423 22 16 cc cc NOUN dti-1423 22 17 - - PUNCT dti-1423 22 18 by by ADP dti-1423 22 19 - - PUNCT dti-1423 22 20 nc nc PROPN dti-1423 22 21 3.0 3.0 NUM dti-1423 22 22 license license NOUN dti-1423 22 23 . . PUNCT dti-1423 23 1 correspondence correspondence NOUN dti-1423 23 2 : : PUNCT dti-1423 23 3 kitanaka-hyg@umin.net kitanaka-hyg@umin.net PROPN dti-1423 23 4 paper paper NOUN dti-1423 23 5 subject subject NOUN dti-1423 23 6 to to ADP dti-1423 23 7 independent independent ADJ dti-1423 23 8 expert expert ADJ dti-1423 23 9 single single ADJ dti-1423 23 10 - - PUNCT dti-1423 23 11 blind blind ADJ dti-1423 23 12 peer peer NOUN dti-1423 23 13 review review NOUN dti-1423 23 14 . . PUNCT dti-1423 24 1 all all DET dti-1423 24 2 editorial editorial ADJ dti-1423 24 3 decisions decision NOUN dti-1423 24 4 made make VERB dti-1423 24 5 by by ADP dti-1423 24 6 independent independent ADJ dti-1423 24 7 academic academic ADJ dti-1423 24 8 editor editor NOUN dti-1423 24 9 . . PUNCT dti-1423 25 1 upon upon SCONJ dti-1423 25 2 submission submission NOUN dti-1423 25 3 manuscript manuscript NOUN dti-1423 25 4 was be AUX dti-1423 25 5 subject subject ADJ dti-1423 25 6 to to ADP dti-1423 25 7 anti anti ADJ dti-1423 25 8 - - NOUN dti-1423 25 9 plagiarism plagiarism ADJ dti-1423 25 10 scanning scanning NOUN dti-1423 25 11 . . PUNCT dti-1423 26 1 prior prior ADV dti-1423 26 2 to to ADP dti-1423 26 3 publication publication NOUN dti-1423 26 4 all all DET dti-1423 26 5 authors author NOUN dti-1423 26 6 have have AUX dti-1423 26 7 given give VERB dti-1423 26 8 signed sign VERB dti-1423 26 9 confirmation confirmation NOUN dti-1423 26 10 of of ADP dti-1423 26 11 agreement agreement NOUN dti-1423 26 12 to to ADP dti-1423 26 13 article article NOUN dti-1423 26 14 publication publication NOUN dti-1423 26 15 and and CCONJ dti-1423 26 16 compliance compliance NOUN dti-1423 26 17 with with ADP dti-1423 26 18 all all DET dti-1423 26 19 applicable applicable ADJ dti-1423 26 20 ethical ethical ADJ dti-1423 26 21 and and CCONJ dti-1423 26 22 legal legal ADJ dti-1423 26 23 requirements requirement NOUN dti-1423 26 24 , , PUNCT dti-1423 26 25 including include VERB dti-1423 26 26 the the DET dti-1423 26 27 accuracy accuracy NOUN dti-1423 26 28 of of ADP dti-1423 26 29 author author NOUN dti-1423 26 30 and and CCONJ dti-1423 26 31 contributor contributor NOUN dti-1423 26 32 information information NOUN dti-1423 26 33 , , PUNCT dti-1423 26 34 disclosure disclosure NOUN dti-1423 26 35 of of ADP dti-1423 26 36 competing compete VERB dti-1423 26 37 interests interest NOUN dti-1423 26 38 and and CCONJ dti-1423 26 39 funding funding NOUN dti-1423 26 40 sources source NOUN dti-1423 26 41 , , PUNCT dti-1423 26 42 compliance compliance NOUN dti-1423 26 43 with with ADP dti-1423 26 44 ethical ethical ADJ dti-1423 26 45 requirements requirement NOUN dti-1423 26 46 relating relate VERB dti-1423 26 47 to to ADP dti-1423 26 48 human human ADJ dti-1423 26 49 and and CCONJ dti-1423 26 50 animal animal NOUN dti-1423 26 51 study study NOUN dti-1423 26 52 participants participant NOUN dti-1423 26 53 , , PUNCT dti-1423 26 54 and and CCONJ dti-1423 26 55 compliance compliance NOUN dti-1423 26 56 with with ADP dti-1423 26 57 any any DET dti-1423 26 58 copyright copyright NOUN dti-1423 26 59 requirements requirement NOUN dti-1423 26 60 of of ADP dti-1423 26 61 third third ADJ dti-1423 26 62 parties party NOUN dti-1423 26 63 . . PUNCT dti-1423 27 1 this this DET dti-1423 27 2 journal journal NOUN dti-1423 27 3 is be AUX dti-1423 27 4 a a DET dti-1423 27 5 member member NOUN dti-1423 27 6 of of ADP dti-1423 27 7 the the DET dti-1423 27 8 committee committee NOUN dti-1423 27 9 on on ADP dti-1423 27 10 publication publication NOUN dti-1423 27 11 ethics ethic NOUN dti-1423 27 12 ( ( PUNCT dti-1423 27 13 cope cope PROPN dti-1423 27 14 ) ) PUNCT dti-1423 27 15 . . PUNCT dti-1423 28 1 provenance provenance NOUN dti-1423 28 2 : : PUNCT dti-1423 28 3 the the DET dti-1423 28 4 authors author NOUN dti-1423 28 5 were be AUX dti-1423 28 6 invited invite VERB dti-1423 28 7 to to PART dti-1423 28 8 submit submit VERB dti-1423 28 9 this this DET dti-1423 28 10 paper paper NOUN dti-1423 28 11 . . PUNCT dti-1423 29 1 published publish VERB dti-1423 29 2 by by ADP dti-1423 29 3 libertas liberta NOUN dti-1423 29 4 academica academica PROPN dti-1423 29 5 . . PUNCT dti-1423 30 1 learn learn VERB dti-1423 30 2 more more ADJ dti-1423 30 3 about about ADP dti-1423 30 4 this this DET dti-1423 30 5 journal journal NOUN dti-1423 30 6 . . PUNCT dti-1423 31 1 journal journal PROPN dti-1423 31 2 name name PROPN dti-1423 31 3 : : PUNCT dti-1423 31 4 drug drug NOUN dti-1423 31 5 target target NOUN dti-1423 31 6 insights insight NOUN dti-1423 31 7 journal journal NOUN dti-1423 31 8 type type NOUN dti-1423 31 9 : : PUNCT dti-1423 31 10 review review NOUN dti-1423 31 11 year year NOUN dti-1423 31 12 : : PUNCT dti-1423 31 13 2016 2016 NUM dti-1423 31 14 volume volume NOUN dti-1423 31 15 : : PUNCT dti-1423 31 16 10 10 NUM dti-1423 31 17 running run VERB dti-1423 31 18 head head NOUN dti-1423 31 19 verso verso NOUN dti-1423 31 20 : : PUNCT dti-1423 31 21 kitanaka kitanaka PROPN dti-1423 31 22 et et PROPN dti-1423 31 23 al al PROPN dti-1423 31 24 running run VERB dti-1423 31 25 head head NOUN dti-1423 31 26 recto recto NOUN dti-1423 31 27 : : PUNCT dti-1423 31 28 treatment treatment NOUN dti-1423 31 29 for for ADP dti-1423 31 30 methamphetamine methamphetamine NOUN dti-1423 31 31 overdose overdose NOUN dti-1423 31 32 introduction introduction NOUN dti-1423 31 33 methamphetamine methamphetamine NOUN dti-1423 31 34 ( ( PUNCT dti-1423 31 35 meth meth NOUN dti-1423 31 36 ; ; PUNCT dti-1423 31 37 n n CCONJ dti-1423 31 38 - - PUNCT dti-1423 31 39 methyl-1 methyl-1 NUM dti-1423 31 40 - - PUNCT dti-1423 31 41 phenylpropan-2 phenylpropan-2 NOUN dti-1423 31 42 amine amine NOUN dti-1423 31 43 ) ) PUNCT dti-1423 31 44 is be AUX dti-1423 31 45 a a DET dti-1423 31 46 powerful powerful ADJ dti-1423 31 47 psychomotor psychomotor NOUN dti-1423 31 48 stimulant stimulant NOUN dti-1423 31 49 similar similar ADJ dti-1423 31 50 in in ADP dti-1423 31 51 structure structure NOUN dti-1423 31 52 to to ADP dti-1423 31 53 amphetamine amphetamine PROPN dti-1423 31 54 ( ( PUNCT dti-1423 31 55 amph amph NOUN dti-1423 31 56 ; ; PUNCT dti-1423 31 57 1 1 NUM dti-1423 31 58 - - PUNCT dti-1423 31 59 phenylpropan-2 phenylpropan-2 NUM dti-1423 31 60 - - PUNCT dti-1423 31 61 amine amine NOUN dti-1423 31 62 ) ) PUNCT dti-1423 31 63 . . PUNCT dti-1423 32 1 although although SCONJ dti-1423 32 2 meth meth NOUN dti-1423 32 3 is be AUX dti-1423 32 4 used use VERB dti-1423 32 5 in in ADP dti-1423 32 6 the the DET dti-1423 32 7 treatment treatment NOUN dti-1423 32 8 of of ADP dti-1423 32 9 attention attention NOUN dti-1423 32 10 - - PUNCT dti-1423 32 11 deficit deficit NOUN dti-1423 32 12 hyperactivity hyperactivity NOUN dti-1423 32 13 disorder disorder NOUN dti-1423 32 14 , , PUNCT dti-1423 32 15 narcolepsy narcolepsy NOUN dti-1423 32 16 , , PUNCT dti-1423 32 17 and and CCONJ dti-1423 32 18 severe severe ADJ dti-1423 32 19 obesity,1 obesity,1 NOUN dti-1423 32 20 the the DET dti-1423 32 21 clinical clinical ADJ dti-1423 32 22 utility utility NOUN dti-1423 32 23 of of ADP dti-1423 32 24 meth meth NOUN dti-1423 32 25 is be AUX dti-1423 32 26 limited limit VERB dti-1423 32 27 by by ADP dti-1423 32 28 its its PRON dti-1423 32 29 abuse abuse NOUN dti-1423 32 30 potential potential NOUN dti-1423 32 31 . . PUNCT dti-1423 33 1 meth meth NOUN dti-1423 33 2 is be AUX dti-1423 33 3 typically typically ADV dti-1423 33 4 abused abuse VERB dti-1423 33 5 via via ADP dti-1423 33 6 intranasal intranasal NOUN dti-1423 33 7 , , PUNCT dti-1423 33 8 intravenous intravenous ADJ dti-1423 33 9 , , PUNCT dti-1423 33 10 or or CCONJ dti-1423 33 11 inhalation inhalation NOUN dti-1423 33 12 routes route NOUN dti-1423 33 13 of of ADP dti-1423 33 14 administration administration NOUN dti-1423 33 15 , , PUNCT dti-1423 33 16 rather rather ADV dti-1423 33 17 than than ADP dti-1423 33 18 orally orally ADV dti-1423 33 19 , , PUNCT dti-1423 33 20 worldwide worldwide ADV dti-1423 33 21 , , PUNCT dti-1423 33 22 including include VERB dti-1423 33 23 japan japan PROPN dti-1423 33 24 and and CCONJ dti-1423 33 25 the the DET dti-1423 33 26 united united PROPN dti-1423 33 27 states.2,3 states.2,3 PROPN dti-1423 33 28 meth meth NOUN dti-1423 33 29 addiction addiction NOUN dti-1423 33 30 , , PUNCT dti-1423 33 31 including include VERB dti-1423 33 32 adverse adverse ADJ dti-1423 33 33 effects effect NOUN dti-1423 33 34 associated associate VERB dti-1423 33 35 with with ADP dti-1423 33 36 acute acute ADJ dti-1423 33 37 meth meth NOUN dti-1423 33 38 use use NOUN dti-1423 33 39 and and CCONJ dti-1423 33 40 long long ADJ dti-1423 33 41 - - PUNCT dti-1423 33 42 term term NOUN dti-1423 33 43 effects effect NOUN dti-1423 33 44 associated associate VERB dti-1423 33 45 with with ADP dti-1423 33 46 meth meth NOUN dti-1423 33 47 addiction addiction NOUN dti-1423 33 48 , , PUNCT dti-1423 33 49 is be AUX dti-1423 33 50 a a DET dti-1423 33 51 serious serious ADJ dti-1423 33 52 public public ADJ dti-1423 33 53 health health NOUN dti-1423 33 54 problem.4–8 problem.4–8 NOUN dti-1423 33 55 currently currently ADV dti-1423 33 56 , , PUNCT dti-1423 33 57 there there PRON dti-1423 33 58 are be VERB dti-1423 33 59 no no DET dti-1423 33 60 effective effective ADJ dti-1423 33 61 treatments treatment NOUN dti-1423 33 62 for for ADP dti-1423 33 63 meth meth NOUN dti-1423 33 64 addiction addiction NOUN dti-1423 33 65 , , PUNCT dti-1423 33 66 abuse abuse NOUN dti-1423 33 67 or or CCONJ dti-1423 33 68 acute acute NOUN dti-1423 33 69 overdose.7,9,10 overdose.7,9,10 NOUN dti-1423 33 70 the the DET dti-1423 33 71 molecular molecular ADJ dti-1423 33 72 basis basis NOUN dti-1423 33 73 of of ADP dti-1423 33 74 action action NOUN dti-1423 33 75 of of ADP dti-1423 33 76 meth meth NOUN dti-1423 33 77 is be AUX dti-1423 33 78 considered consider VERB dti-1423 33 79 to to PART dti-1423 33 80 be be AUX dti-1423 33 81 very very ADV dti-1423 33 82 similar similar ADJ dti-1423 33 83 to to ADP dti-1423 33 84 that that PRON dti-1423 33 85 of of ADP dti-1423 33 86 amph amph NOUN dti-1423 33 87 because because SCONJ dti-1423 33 88 of of ADP dti-1423 33 89 their their PRON dti-1423 33 90 structural structural ADJ dti-1423 33 91 similarities similarity NOUN dti-1423 33 92 . . PUNCT dti-1423 34 1 meth meth NOUN dti-1423 34 2 interacts interact VERB dti-1423 34 3 with with ADP dti-1423 34 4 proteins protein NOUN dti-1423 34 5 that that PRON dti-1423 34 6 affect affect VERB dti-1423 34 7 monoamine monoamine ADJ dti-1423 34 8 function function NOUN dti-1423 34 9 , , PUNCT dti-1423 34 10 including include VERB dti-1423 34 11 the the DET dti-1423 34 12 dopamine dopamine NOUN dti-1423 34 13 transporter transporter NOUN dti-1423 34 14 ( ( PUNCT dti-1423 34 15 dat dat PROPN dti-1423 34 16 ) ) PUNCT dti-1423 34 17 , , PUNCT dti-1423 34 18 monoamine monoamine NOUN dti-1423 34 19 oxidases oxidase NOUN dti-1423 34 20 ( ( PUNCT dti-1423 34 21 maos maos PROPN dti-1423 34 22 ) ) PUNCT dti-1423 34 23 , , PUNCT dti-1423 34 24 and and CCONJ dti-1423 34 25 the the DET dti-1423 34 26 vesicular vesicular ADJ dti-1423 34 27 monoamine monoamine NOUN dti-1423 34 28 transporter-2 transporter-2 NUM dti-1423 34 29 ( ( PUNCT dti-1423 34 30 vmat2 vmat2 PROPN dti-1423 34 31 ) ) PUNCT dti-1423 34 32 , , PUNCT dti-1423 34 33 inhibiting inhibit VERB dti-1423 34 34 their their PRON dti-1423 34 35 functions function NOUN dti-1423 34 36 in in ADP dti-1423 34 37 a a DET dti-1423 34 38 manner manner NOUN dti-1423 34 39 similar similar ADJ dti-1423 34 40 to to ADP dti-1423 34 41 amph,11,12 amph,11,12 PROPN dti-1423 34 42 although although SCONJ dti-1423 34 43 with with ADP dti-1423 34 44 somewhat somewhat ADV dti-1423 34 45 different different ADJ dti-1423 34 46 potencies potency NOUN dti-1423 34 47 on on ADP dti-1423 34 48 dopamine dopamine NOUN dti-1423 34 49 transport.13,14 transport.13,14 NOUN dti-1423 34 50 meth meth NOUN dti-1423 34 51 inhibition inhibition NOUN dti-1423 34 52 of of ADP dti-1423 34 53 dat dat NOUN dti-1423 34 54 , , PUNCT dti-1423 34 55 mao mao PROPN dti-1423 34 56 , , PUNCT dti-1423 34 57 and and CCONJ dti-1423 34 58 vmat2 vmat2 NOUN dti-1423 34 59 results result NOUN dti-1423 34 60 in in ADP dti-1423 34 61 the the DET dti-1423 34 62 elevation elevation NOUN dti-1423 34 63 of of ADP dti-1423 34 64 presynaptic presynaptic ADJ dti-1423 34 65 cytosolic cytosolic NOUN dti-1423 34 66 da da PROPN dti-1423 34 67 levels level NOUN dti-1423 34 68 and and CCONJ dti-1423 34 69 the the DET dti-1423 34 70 impulse impulse ADJ dti-1423 34 71 - - PUNCT dti-1423 34 72 independent independent ADJ dti-1423 34 73 release release NOUN dti-1423 34 74 of of ADP dti-1423 34 75 dopamine dopamine NOUN dti-1423 34 76 into into ADP dti-1423 34 77 the the DET dti-1423 34 78 synaptic synaptic ADJ dti-1423 34 79 clefts cleft NOUN dti-1423 34 80 of of ADP dti-1423 34 81 the the DET dti-1423 34 82 dopaminergic dopaminergic ADJ dti-1423 34 83 neurons neuron NOUN dti-1423 34 84 via via ADP dti-1423 34 85 reverse reverse ADJ dti-1423 34 86 transport transport NOUN dti-1423 34 87 mediated mediate VERB dti-1423 34 88 by by ADP dti-1423 34 89 dat dat PROPN dti-1423 34 90 . . PUNCT dti-1423 35 1 the the DET dti-1423 35 2 abnormally abnormally ADV dti-1423 35 3 released release VERB dti-1423 35 4 dopamine dopamine NOUN dti-1423 35 5 then then ADV dti-1423 35 6 binds bind VERB dti-1423 35 7 to to PART dti-1423 35 8 preand preand VERB dti-1423 35 9 postsynaptic postsynaptic ADJ dti-1423 35 10 dopamine dopamine NOUN dti-1423 35 11 d1 d1 PROPN dti-1423 35 12 and and CCONJ dti-1423 35 13 d2 d2 NOUN dti-1423 35 14 receptors receptor NOUN dti-1423 35 15 , , PUNCT dti-1423 35 16 resulting result VERB dti-1423 35 17 in in ADP dti-1423 35 18 behavioral behavioral ADJ dti-1423 35 19 and and CCONJ dti-1423 35 20 psychological psychological ADJ dti-1423 35 21 alterations.15 alterations.15 NOUN dti-1423 35 22 behavioral behavioral ADJ dti-1423 35 23 alterations alteration NOUN dti-1423 35 24 in in ADP dti-1423 35 25 animals animal NOUN dti-1423 35 26 are be AUX dti-1423 35 27 augmented augment VERB dti-1423 35 28 with with ADP dti-1423 35 29 repeated repeat VERB dti-1423 35 30 treatment treatment NOUN dti-1423 35 31 in in ADP dti-1423 35 32 a a DET dti-1423 35 33 dose dose NOUN dti-1423 35 34 - - PUNCT dti-1423 35 35 dependent dependent ADJ dti-1423 35 36 manner manner NOUN dti-1423 35 37 ( ( PUNCT dti-1423 35 38 eg eg NOUN dti-1423 35 39 , , PUNCT dti-1423 35 40 sensitization).16 sensitization).16 PROPN dti-1423 35 41 dopamine dopamine NOUN dti-1423 35 42 receptor receptor NOUN dti-1423 35 43 antagonists antagonist NOUN dti-1423 35 44 drastically drastically ADV dti-1423 35 45 attenuate attenuate VERB dti-1423 35 46 meth meth NOUN dti-1423 35 47 - - PUNCT dti-1423 35 48 induced induce VERB dti-1423 35 49 behavioral behavioral ADJ dti-1423 35 50 and and CCONJ dti-1423 35 51 psychological psychological ADJ dti-1423 35 52 alterations alteration NOUN dti-1423 35 53 , , PUNCT dti-1423 35 54 including include VERB dti-1423 35 55 both both CCONJ dti-1423 35 56 acute acute ADJ dti-1423 35 57 and and CCONJ dti-1423 35 58 sensitized sensitize VERB dti-1423 35 59 effects effect NOUN dti-1423 35 60 . . PUNCT dti-1423 36 1 in in ADP dti-1423 36 2 human human ADJ dti-1423 36 3 beings being NOUN dti-1423 36 4 , , PUNCT dti-1423 36 5 meth meth NOUN dti-1423 36 6 sensitization sensitization NOUN dti-1423 36 7 is be AUX dti-1423 36 8 associated associate VERB dti-1423 36 9 with with ADP dti-1423 36 10 progressive progressive ADJ dti-1423 36 11 development development NOUN dti-1423 36 12 of of ADP dti-1423 36 13 meth meth NOUN dti-1423 36 14 - - PUNCT dti-1423 36 15 induced induce VERB dti-1423 36 16 psychosis,17 psychosis,17 NOUN dti-1423 36 17 which which PRON dti-1423 36 18 is be AUX dti-1423 36 19 improved improve VERB dti-1423 36 20 by by ADP dti-1423 36 21 treatment treatment NOUN dti-1423 36 22 with with ADP dti-1423 36 23 haloperidol,18 haloperidol,18 PROPN dti-1423 36 24 a a DET dti-1423 36 25 classical classical ADJ dti-1423 36 26 antipsychotic antipsychotic NOUN dti-1423 36 27 that that PRON dti-1423 36 28 has have VERB dti-1423 36 29 antagonistic antagonistic ADJ dti-1423 36 30 actions action NOUN dti-1423 36 31 at at ADP dti-1423 36 32 dopamine dopamine NOUN dti-1423 36 33 d2 d2 NOUN dti-1423 36 34 receptors receptor NOUN dti-1423 36 35 , , PUNCT dti-1423 36 36 but but CCONJ dti-1423 36 37 with with ADP dti-1423 36 38 pronounced pronounce VERB dti-1423 36 39 extrapyramidal extrapyramidal ADJ dti-1423 36 40 side side NOUN dti-1423 36 41 effects.19,20 effects.19,20 ADJ dti-1423 36 42 in in ADP dti-1423 36 43 the the DET dti-1423 36 44 search search NOUN dti-1423 36 45 for for ADP dti-1423 36 46 an an DET dti-1423 36 47 effective effective ADJ dti-1423 36 48 pharmacotherapy pharmacotherapy NOUN dti-1423 36 49 for for ADP dti-1423 36 50 methinduced methinduce VERB dti-1423 36 51 symptoms symptom NOUN dti-1423 36 52 without without ADP dti-1423 36 53 these these DET dti-1423 36 54 adverse adverse ADJ dti-1423 36 55 effects effect NOUN dti-1423 36 56 , , PUNCT dti-1423 36 57 other other ADJ dti-1423 36 58 neuronal neuronal ADJ dti-1423 36 59 systems system NOUN dti-1423 36 60 have have AUX dti-1423 36 61 been be AUX dti-1423 36 62 investigated.21–24 investigated.21–24 NOUN dti-1423 36 63 our our PRON dti-1423 36 64 research research NOUN dti-1423 36 65 has have AUX dti-1423 36 66 focused focus VERB dti-1423 36 67 on on ADP dti-1423 36 68 a a DET dti-1423 36 69 possible possible ADJ dti-1423 36 70 involvement involvement NOUN dti-1423 36 71 of of ADP dti-1423 36 72 brain brain NOUN dti-1423 36 73 histaminergic histaminergic ADJ dti-1423 36 74 systems system NOUN dti-1423 36 75 in in ADP dti-1423 36 76 meth meth NOUN dti-1423 36 77 actions action NOUN dti-1423 36 78 , , PUNCT dti-1423 36 79 especially especially ADV dti-1423 36 80 high high ADV dti-1423 36 81 - - PUNCT dti-1423 36 82 dose dose NOUN dti-1423 36 83 meth meth NOUN dti-1423 36 84 effects effect NOUN dti-1423 36 85 such such ADJ dti-1423 36 86 as as ADP dti-1423 36 87 meth meth NOUN dti-1423 36 88 - - PUNCT dti-1423 36 89 induced induce VERB dti-1423 36 90 stereotypy stereotypy NOUN dti-1423 36 91 in in ADP dti-1423 36 92 mice mouse NOUN dti-1423 36 93 . . PUNCT dti-1423 37 1 here here ADV dti-1423 37 2 , , PUNCT dti-1423 37 3 we we PRON dti-1423 37 4 will will AUX dti-1423 37 5 review review VERB dti-1423 37 6 the the DET dti-1423 37 7 brain brain NOUN dti-1423 37 8 histaminergic histaminergic ADJ dti-1423 37 9 systems system NOUN dti-1423 37 10 , , PUNCT dti-1423 37 11 and and CCONJ dti-1423 37 12 evidence evidence NOUN dti-1423 37 13 that that PRON dti-1423 37 14 may may AUX dti-1423 37 15 suggest suggest VERB dti-1423 37 16 that that SCONJ dti-1423 37 17 alterations alteration NOUN dti-1423 37 18 in in ADP dti-1423 37 19 histaminergic histaminergic ADJ dti-1423 37 20 function function NOUN dti-1423 37 21 may may AUX dti-1423 37 22 be be AUX dti-1423 37 23 a a DET dti-1423 37 24 possible possible ADJ dti-1423 37 25 therapeutic therapeutic ADJ dti-1423 37 26 approach approach NOUN dti-1423 37 27 to to ADP dti-1423 37 28 the the DET dti-1423 37 29 treatment treatment NOUN dti-1423 37 30 of of ADP dti-1423 37 31 meth meth NOUN dti-1423 37 32 overdose overdose NOUN dti-1423 37 33 associated associate VERB dti-1423 37 34 with with ADP dti-1423 37 35 high high ADJ dti-1423 37 36 meth meth NOUN dti-1423 37 37 doses dose NOUN dti-1423 37 38 , , PUNCT dti-1423 37 39 or or CCONJ dti-1423 37 40 the the DET dti-1423 37 41 sensitized sensitize VERB dti-1423 37 42 state state NOUN dti-1423 37 43 associated associate VERB dti-1423 37 44 with with ADP dti-1423 37 45 long long ADJ dti-1423 37 46 - - PUNCT dti-1423 37 47 term term NOUN dti-1423 37 48 meth meth NOUN dti-1423 37 49 use use NOUN dti-1423 37 50 . . PUNCT dti-1423 38 1 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1423 38 2 http://www.la-press.com http://www.la-press.com X dti-1423 38 3 http://dx.doi.org/10.4137/dti.s38342 http://dx.doi.org/10.4137/dti.s38342 PROPN dti-1423 38 4 http://creativecommons.org/licenses/by-nc/3.0/ http://creativecommons.org/licenses/by-nc/3.0/ PROPN dti-1423 38 5 http://creativecommons.org/licenses/by-nc/3.0/ http://creativecommons.org/licenses/by-nc/3.0/ NOUN dti-1423 38 6 mailto:kitanaka-hyg@umin.net mailto:kitanaka-hyg@umin.net NOUN dti-1423 38 7 http://www.la-press.com http://www.la-press.com X dti-1423 39 1 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 AUX dti-1423 39 2 kitanaka kitanaka PROPN dti-1423 39 3 et et PROPN dti-1423 39 4 al al PROPN dti-1423 39 5 2 2 NUM dti-1423 39 6 drug drug NOUN dti-1423 39 7 target target NOUN dti-1423 39 8 insights insight NOUN dti-1423 39 9 2016:10 2016:10 NUM dti-1423 39 10 meth meth NOUN dti-1423 39 11 overdose overdose ADV dti-1423 39 12 : : PUNCT dti-1423 39 13 experimental experimental ADJ dti-1423 39 14 procedures procedure NOUN dti-1423 39 15 and and CCONJ dti-1423 39 16 behavioral behavioral ADJ dti-1423 39 17 effects effect NOUN dti-1423 39 18 in in ADP dti-1423 39 19 rodents rodent NOUN dti-1423 39 20 , , PUNCT dti-1423 39 21 systemic systemic ADJ dti-1423 39 22 administration administration NOUN dti-1423 39 23 of of ADP dti-1423 39 24 meth meth NOUN dti-1423 39 25 induces induce VERB dti-1423 39 26 locomotor locomotor NOUN dti-1423 39 27 hyperactivity hyperactivity NOUN dti-1423 39 28 that that PRON dti-1423 39 29 is be AUX dti-1423 39 30 replaced replace VERB dti-1423 39 31 by by ADP dti-1423 39 32 repetitive repetitive ADJ dti-1423 39 33 and and CCONJ dti-1423 39 34 compulsive compulsive ADJ dti-1423 39 35 behaviors behavior NOUN dti-1423 39 36 called call VERB dti-1423 39 37 stereotypies stereotypie NOUN dti-1423 39 38 at at ADP dti-1423 39 39 higher high ADJ dti-1423 39 40 doses.16,25,26 doses.16,25,26 NOUN dti-1423 39 41 for for ADP dti-1423 39 42 instance instance NOUN dti-1423 39 43 , , PUNCT dti-1423 39 44 a a DET dti-1423 39 45 single single ADJ dti-1423 39 46 administration administration NOUN dti-1423 39 47 of of ADP dti-1423 39 48 meth meth NOUN dti-1423 39 49 at at ADP dti-1423 39 50 doses dose NOUN dti-1423 39 51 of of ADP dti-1423 39 52 0.5–2 0.5–2 PROPN dti-1423 39 53     SPACE dti-1423 39 54 mg mg PROPN dti-1423 39 55 / / SYM dti-1423 39 56 kg kg PROPN dti-1423 39 57 induces induce VERB dti-1423 39 58 hyperlocomotion,16,27–30 hyperlocomotion,16,27–30 PROPN dti-1423 39 59 while while SCONJ dti-1423 39 60 rodents rodent NOUN dti-1423 39 61 exhibit exhibit VERB dti-1423 39 62 stereotypy stereotypy NOUN dti-1423 39 63 when when SCONJ dti-1423 39 64 treated treat VERB dti-1423 39 65 with with ADP dti-1423 39 66 higher high ADJ dti-1423 39 67 doses dose NOUN dti-1423 39 68 of of ADP dti-1423 39 69 meth meth NOUN dti-1423 39 70 ( ( PUNCT dti-1423 39 71 5–20 5–20 NOUN dti-1423 39 72     SPACE dti-1423 39 73 mg mg PROPN dti-1423 39 74 / / SYM dti-1423 39 75 kg).31–37 kg).31–37 NOUN dti-1423 39 76 rodents rodent NOUN dti-1423 39 77 exhibiting exhibit VERB dti-1423 39 78 stereotypy stereotypy NOUN dti-1423 39 79 after after ADP dti-1423 39 80 acute acute ADJ dti-1423 39 81 high high ADJ dti-1423 39 82 doses dose NOUN dti-1423 39 83 of of ADP dti-1423 39 84 meth meth NOUN dti-1423 39 85 are be AUX dti-1423 39 86 considered consider VERB dti-1423 39 87 to to PART dti-1423 39 88 be be AUX dti-1423 39 89 a a DET dti-1423 39 90 model model NOUN dti-1423 39 91 for for ADP dti-1423 39 92 meth meth NOUN dti-1423 39 93 overdose overdose ADV dti-1423 39 94 . . PUNCT dti-1423 40 1 to to PART dti-1423 40 2 evaluate evaluate VERB dti-1423 40 3 meth meth NOUN dti-1423 40 4 - - PUNCT dti-1423 40 5 induced induce VERB dti-1423 40 6 stereotypy stereotypy NOUN dti-1423 40 7 reproducibly reproducibly ADV dti-1423 40 8 , , PUNCT dti-1423 40 9 tatsuta tatsuta INTJ dti-1423 40 10 et et PROPN dti-1423 40 11 al al PROPN dti-1423 40 12 developed develop VERB dti-1423 40 13 an an DET dti-1423 40 14 experimental experimental ADJ dti-1423 40 15 procedure procedure NOUN dti-1423 40 16 using use VERB dti-1423 40 17 mice mouse NOUN dti-1423 40 18 as as ADP dti-1423 40 19 follows35 follows35 NOUN dti-1423 40 20 : : PUNCT dti-1423 40 21 test test NOUN dti-1423 40 22 subjects subject NOUN dti-1423 40 23 are be AUX dti-1423 40 24 placed place VERB dti-1423 40 25 in in ADP dti-1423 40 26 a a DET dti-1423 40 27 transparent transparent ADJ dti-1423 40 28 acrylic acrylic NOUN dti-1423 40 29 box box NOUN dti-1423 40 30 ( ( PUNCT dti-1423 40 31 30 30 NUM dti-1423 40 32     SPACE dti-1423 40 33 × × NOUN dti-1423 40 34     SPACE dti-1423 40 35 30 30 NUM dti-1423 40 36     SPACE dti-1423 40 37 × × NOUN dti-1423 40 38     SPACE dti-1423 40 39 35 35 NUM dti-1423 40 40     SPACE dti-1423 40 41 cm cm NOUN dti-1423 40 42 ) ) PUNCT dti-1423 40 43 with with ADP dti-1423 40 44 ~25 ~25 NOUN dti-1423 40 45     SPACE dti-1423 40 46 g g NOUN dti-1423 40 47 of of ADP dti-1423 40 48 fresh fresh ADJ dti-1423 40 49 wood wood NOUN dti-1423 40 50 chips chip NOUN dti-1423 40 51 spread spread VERB dti-1423 40 52 on on ADP dti-1423 40 53 the the DET dti-1423 40 54 floor floor NOUN dti-1423 40 55 of of ADP dti-1423 40 56 the the DET dti-1423 40 57 chamber chamber NOUN dti-1423 40 58 and and CCONJ dti-1423 40 59 observed observe VERB dti-1423 40 60 for for ADP dti-1423 40 61 stereotypy stereotypy NOUN dti-1423 40 62 for for ADP dti-1423 40 63 one one NUM dti-1423 40 64 hour hour NOUN dti-1423 40 65 after after ADP dti-1423 40 66 drug drug NOUN dti-1423 40 67 challenge challenge NOUN dti-1423 40 68 by by ADP dti-1423 40 69 observers observer NOUN dti-1423 40 70 unaware unaware ADJ dti-1423 40 71 of of ADP dti-1423 40 72 the the DET dti-1423 40 73 treatments treatment NOUN dti-1423 40 74 . . PUNCT dti-1423 41 1 meth meth NOUN dti-1423 41 2 - - PUNCT dti-1423 41 3 induced induce VERB dti-1423 41 4 stereotypy stereotypy NOUN dti-1423 41 5 lasts last VERB dti-1423 41 6 for for ADP dti-1423 41 7 ~170 ~170 NOUN dti-1423 41 8     SPACE dti-1423 41 9 minutes minute NOUN dti-1423 41 10 after after ADP dti-1423 41 11 a a DET dti-1423 41 12 10 10 NUM dti-1423 41 13     SPACE dti-1423 41 14 mg mg PROPN dti-1423 41 15 / / SYM dti-1423 41 16 kg kg PROPN dti-1423 41 17 i.p i.p PROPN dti-1423 41 18 . . PROPN dti-1423 41 19 injection injection NOUN dti-1423 41 20 in in ADP dti-1423 41 21 mice.35 mice.35 NOUN dti-1423 41 22 the the DET dti-1423 41 23 frequencies frequency NOUN dti-1423 41 24 of of ADP dti-1423 41 25 each each DET dti-1423 41 26 behavioral behavioral ADJ dti-1423 41 27 component component NOUN dti-1423 41 28 of of ADP dti-1423 41 29 stereotypical stereotypical ADJ dti-1423 41 30 behavior behavior NOUN dti-1423 41 31 ( ( PUNCT dti-1423 41 32 see see VERB dti-1423 41 33 description description NOUN dti-1423 41 34 of of ADP dti-1423 41 35 categories category NOUN dti-1423 41 36 below below ADV dti-1423 41 37 ) ) PUNCT dti-1423 41 38 observed observe VERB dti-1423 41 39 for for ADP dti-1423 41 40 two two NUM dti-1423 41 41 - - PUNCT dti-1423 41 42 hour hour NOUN dti-1423 41 43 postinjection postinjection NOUN dti-1423 41 44 are be AUX dti-1423 41 45 the the DET dti-1423 41 46 same same ADJ dti-1423 41 47 as as SCONJ dti-1423 41 48 the the DET dti-1423 41 49 frequencies frequency NOUN dti-1423 41 50 observed observe VERB dti-1423 41 51 for for ADP dti-1423 41 52 one one NUM dti-1423 41 53 hour hour NOUN dti-1423 41 54 ( ( PUNCT dti-1423 41 55 two two NUM dti-1423 41 56 - - PUNCT dti-1423 41 57 hour hour NOUN dti-1423 41 58 observations38 observations38 NOUN dti-1423 41 59 vs. vs. ADP dti-1423 41 60 one one NUM dti-1423 41 61 - - PUNCT dti-1423 41 62 hour hour NOUN dti-1423 41 63 observations39 observations39 NOUN dti-1423 41 64 ) ) PUNCT dti-1423 41 65 . . PUNCT dti-1423 42 1 therefore therefore ADV dti-1423 42 2 , , PUNCT dti-1423 42 3 the the DET dti-1423 42 4 period period NOUN dti-1423 42 5 of of ADP dti-1423 42 6 one one NUM dti-1423 42 7 hour hour NOUN dti-1423 42 8 was be AUX dti-1423 42 9 chosen choose VERB dti-1423 42 10 in in ADP dti-1423 42 11 all all PRON dti-1423 42 12 of of ADP dti-1423 42 13 our our PRON dti-1423 42 14 subsequent subsequent ADJ dti-1423 42 15 experiments experiment NOUN dti-1423 42 16 . . PUNCT dti-1423 43 1 behavior behavior NOUN dti-1423 43 2 is be AUX dti-1423 43 3 assessed assess VERB dti-1423 43 4 at at ADP dti-1423 43 5 30 30 NUM dti-1423 43 6 - - PUNCT dti-1423 43 7 second second NOUN dti-1423 43 8 intervals interval NOUN dti-1423 43 9 , , PUNCT dti-1423 43 10 and and CCONJ dti-1423 43 11 the the DET dti-1423 43 12 predominant predominant ADJ dti-1423 43 13 behavior behavior NOUN dti-1423 43 14 observed observe VERB dti-1423 43 15 during during ADP dti-1423 43 16 each each DET dti-1423 43 17 interval interval NOUN dti-1423 43 18 is be AUX dti-1423 43 19 recorded record VERB dti-1423 43 20 . . PUNCT dti-1423 44 1 since since SCONJ dti-1423 44 2 individual individual ADJ dti-1423 44 3 stereotypical stereotypical ADJ dti-1423 44 4 behaviors behavior NOUN dti-1423 44 5 are be AUX dti-1423 44 6 unchanged unchanged ADJ dti-1423 44 7 for for ADP dti-1423 44 8 long long ADJ dti-1423 44 9 periods period NOUN dti-1423 44 10 ( ( PUNCT dti-1423 44 11 .30 .30 NUM dti-1423 44 12 seconds second NOUN dti-1423 44 13 ) ) PUNCT dti-1423 44 14 after after ADP dti-1423 44 15 drug drug NOUN dti-1423 44 16 treatment treatment NOUN dti-1423 44 17 , , PUNCT dti-1423 44 18 it it PRON dti-1423 44 19 is be AUX dti-1423 44 20 possible possible ADJ dti-1423 44 21 to to PART dti-1423 44 22 record record VERB dti-1423 44 23 the the DET dti-1423 44 24 observations observation NOUN dti-1423 44 25 by by ADP dti-1423 44 26 hand hand NOUN dti-1423 44 27 . . PUNCT dti-1423 45 1 the the DET dti-1423 45 2 behaviors behavior NOUN dti-1423 45 3 scored score VERB dti-1423 45 4 are be AUX dti-1423 45 5 inactive inactive ADJ dti-1423 45 6 ( ( PUNCT dti-1423 45 7 awake awake ADJ dti-1423 45 8 and and CCONJ dti-1423 45 9 inactive inactive ADJ dti-1423 45 10 , , PUNCT dti-1423 45 11 or or CCONJ dti-1423 45 12 sleeping sleeping NOUN dti-1423 45 13 ) ) PUNCT dti-1423 45 14 , , PUNCT dti-1423 45 15 ambulation ambulation NOUN dti-1423 45 16 , , PUNCT dti-1423 45 17 rearing rear VERB dti-1423 45 18 ( ( PUNCT dti-1423 45 19 standing stand VERB dti-1423 45 20 on on ADP dti-1423 45 21 the the DET dti-1423 45 22 hind hind NOUN dti-1423 45 23 legs leg NOUN dti-1423 45 24 , , PUNCT dti-1423 45 25 with with ADP dti-1423 45 26 forelegs foreleg NOUN dti-1423 45 27 unsupported unsupported ADJ dti-1423 45 28 or or CCONJ dti-1423 45 29 supported support VERB dti-1423 45 30 on on ADP dti-1423 45 31 the the DET dti-1423 45 32 walls wall NOUN dti-1423 45 33 ) ) PUNCT dti-1423 45 34 , , PUNCT dti-1423 45 35 persistent persistent ADJ dti-1423 45 36 locomotion locomotion NOUN dti-1423 45 37 , , PUNCT dti-1423 45 38 head head NOUN dti-1423 45 39 bobbing bob VERB dti-1423 45 40 ( ( PUNCT dti-1423 45 41 up up ADP dti-1423 45 42 - - PUNCT dti-1423 45 43 and and CCONJ dti-1423 45 44 - - PUNCT dti-1423 45 45 down down ADJ dti-1423 45 46 movements movement NOUN dti-1423 45 47 of of ADP dti-1423 45 48 the the DET dti-1423 45 49 head head NOUN dti-1423 45 50 ) ) PUNCT dti-1423 45 51 , , PUNCT dti-1423 45 52 continuous continuous ADJ dti-1423 45 53 sniffing sniffing NOUN dti-1423 45 54 , , PUNCT dti-1423 45 55 circling circling NOUN dti-1423 45 56 , , PUNCT dti-1423 45 57 and and CCONJ dti-1423 45 58 continuous continuous ADJ dti-1423 45 59 nail nail NOUN dti-1423 45 60 and/or and/or CCONJ dti-1423 45 61 wood wood NOUN dti-1423 45 62 chip chip NOUN dti-1423 45 63 biting bite VERB dti-1423 45 64 or or CCONJ dti-1423 45 65 licking lick VERB dti-1423 45 66 . . PUNCT dti-1423 46 1 ambulation ambulation NOUN dti-1423 46 2 , , PUNCT dti-1423 46 3 rearing rearing NOUN dti-1423 46 4 , , PUNCT dti-1423 46 5 and and CCONJ dti-1423 46 6 persistent persistent ADJ dti-1423 46 7 locomotion locomotion NOUN dti-1423 46 8 are be AUX dti-1423 46 9 considered consider VERB dti-1423 46 10 to to PART dti-1423 46 11 be be AUX dti-1423 46 12 exploratory exploratory ADJ dti-1423 46 13 behaviors behavior NOUN dti-1423 46 14 , , PUNCT dti-1423 46 15 and and CCONJ dti-1423 46 16 the the DET dti-1423 46 17 last last ADJ dti-1423 46 18 four four NUM dti-1423 46 19 categories category NOUN dti-1423 46 20 are be AUX dti-1423 46 21 considered consider VERB dti-1423 46 22 stereotypies stereotypie NOUN dti-1423 46 23 . . PUNCT dti-1423 47 1 stereotypical stereotypical ADJ dti-1423 47 2 cage cage NOUN dti-1423 47 3 climbing40 climbing40 NOUN dti-1423 47 4 is be AUX dti-1423 47 5 not not PART dti-1423 47 6 observed observe VERB dti-1423 47 7 in in ADP dti-1423 47 8 our our PRON dti-1423 47 9 experimental experimental ADJ dti-1423 47 10 procedure procedure NOUN dti-1423 47 11 because because SCONJ dti-1423 47 12 of of ADP dti-1423 47 13 the the DET dti-1423 47 14 use use NOUN dti-1423 47 15 of of ADP dti-1423 47 16 an an DET dti-1423 47 17 acrylic acrylic NOUN dti-1423 47 18 test test NOUN dti-1423 47 19 chamber chamber NOUN dti-1423 47 20 without without ADP dti-1423 47 21 a a DET dti-1423 47 22 stainless stainless ADJ dti-1423 47 23 steel steel NOUN dti-1423 47 24 grid grid NOUN dti-1423 47 25 top top NOUN dti-1423 47 26 . . PUNCT dti-1423 48 1 persistent persistent ADJ dti-1423 48 2 locomotion locomotion NOUN dti-1423 48 3 is be AUX dti-1423 48 4 not not PART dti-1423 48 5 classified classify VERB dti-1423 48 6 as as ADP dti-1423 48 7 stereotypy stereotypy PROPN dti-1423 48 8 because because SCONJ dti-1423 48 9 the the DET dti-1423 48 10 mice mouse NOUN dti-1423 48 11 scored score VERB dti-1423 48 12 as as ADP dti-1423 48 13 having have VERB dti-1423 48 14 persistent persistent ADJ dti-1423 48 15 locomotion locomotion NOUN dti-1423 48 16 show show VERB dti-1423 48 17 horizontal horizontal ADJ dti-1423 48 18 locomotor locomotor NOUN dti-1423 48 19 activity activity NOUN dti-1423 48 20 less less ADJ dti-1423 48 21 than than ADP dti-1423 48 22 or or CCONJ dti-1423 48 23 equal equal ADJ dti-1423 48 24 to to ADP dti-1423 48 25 that that PRON dti-1423 48 26 displayed display VERB dti-1423 48 27 by by ADP dti-1423 48 28 mice mouse NOUN dti-1423 48 29 showing show VERB dti-1423 48 30 hyperlocomotion hyperlocomotion NOUN dti-1423 48 31 induced induce VERB dti-1423 48 32 by by ADP dti-1423 48 33 1 1 NUM dti-1423 48 34     SPACE dti-1423 48 35 mg mg PROPN dti-1423 48 36 / / SYM dti-1423 48 37 kg kg PROPN dti-1423 48 38 meth meth NOUN dti-1423 48 39 ( ( PUNCT dti-1423 48 40 which which PRON dti-1423 48 41 is be AUX dti-1423 48 42 not not PART dti-1423 48 43 generally generally ADV dti-1423 48 44 defined define VERB dti-1423 48 45 as as ADP dti-1423 48 46 a a DET dti-1423 48 47 stereotypy stereotypy NOUN dti-1423 48 48 ) ) PUNCT dti-1423 48 49 measured measure VERB dti-1423 48 50 by by ADP dti-1423 48 51 automated automate VERB dti-1423 48 52 animex animex NOUN dti-1423 48 53 auto.41 auto.41 NOUN dti-1423 48 54 the the DET dti-1423 48 55 cumulative cumulative ADJ dti-1423 48 56 number number NOUN dti-1423 48 57 of of ADP dti-1423 48 58 intervals interval NOUN dti-1423 48 59 within within ADP dti-1423 48 60 each each DET dti-1423 48 61 five five NUM dti-1423 48 62 - - PUNCT dti-1423 48 63 minute minute NOUN dti-1423 48 64 period period NOUN dti-1423 48 65 in in ADP dti-1423 48 66 which which PRON dti-1423 48 67 stereotypies stereotypie NOUN dti-1423 48 68 are be AUX dti-1423 48 69 observed observe VERB dti-1423 48 70 is be AUX dti-1423 48 71 evaluated evaluate VERB dti-1423 48 72 as as ADP dti-1423 48 73 a a DET dti-1423 48 74 time time NOUN dti-1423 48 75 course course NOUN dti-1423 48 76 ( ( PUNCT dti-1423 48 77 maximal maximal ADJ dti-1423 48 78 value value NOUN dti-1423 48 79     SPACE dti-1423 49 1 = = NOUN dti-1423 49 2     SPACE dti-1423 49 3 10 10 NUM dti-1423 49 4 ) ) PUNCT dti-1423 49 5 . . PUNCT dti-1423 50 1 animal animal NOUN dti-1423 50 2 handling handling NOUN dti-1423 50 3 and and CCONJ dti-1423 50 4 care care NOUN dti-1423 50 5 were be AUX dti-1423 50 6 conducted conduct VERB dti-1423 50 7 in in ADP dti-1423 50 8 accordance accordance NOUN dti-1423 50 9 with with ADP dti-1423 50 10 the the DET dti-1423 50 11 guide guide NOUN dti-1423 50 12 for for ADP dti-1423 50 13 the the DET dti-1423 50 14 care care NOUN dti-1423 50 15 and and CCONJ dti-1423 50 16 use use NOUN dti-1423 50 17 of of ADP dti-1423 50 18 laboratory laboratory NOUN dti-1423 50 19 animals animal NOUN dti-1423 50 20 ( ( PUNCT dti-1423 50 21 8th 8th ADJ dti-1423 50 22 edition edition NOUN dti-1423 50 23 , , PUNCT dti-1423 50 24 institute institute PROPN dti-1423 50 25 of of ADP dti-1423 50 26 laboratory laboratory NOUN dti-1423 50 27 animal animal NOUN dti-1423 50 28 resources resource NOUN dti-1423 50 29 - - PUNCT dti-1423 50 30 national national PROPN dti-1423 50 31 research research PROPN dti-1423 50 32 council council PROPN dti-1423 50 33 , , PUNCT dti-1423 50 34 national national PROPN dti-1423 50 35 academy academy PROPN dti-1423 50 36 press press PROPN dti-1423 50 37 , , PUNCT dti-1423 50 38 2011 2011 NUM dti-1423 50 39 ) ) PUNCT dti-1423 50 40 , , PUNCT dti-1423 50 41 and and CCONJ dti-1423 50 42 all all DET dti-1423 50 43 experiments experiment NOUN dti-1423 50 44 were be AUX dti-1423 50 45 reviewed review VERB dti-1423 50 46 and and CCONJ dti-1423 50 47 approved approve VERB dti-1423 50 48 by by ADP dti-1423 50 49 the the DET dti-1423 50 50 institutional institutional ADJ dti-1423 50 51 animal animal NOUN dti-1423 50 52 research research NOUN dti-1423 50 53 committee committee NOUN dti-1423 50 54 of of ADP dti-1423 50 55 hyogo hyogo PROPN dti-1423 50 56 college college NOUN dti-1423 50 57 of of ADP dti-1423 50 58 medicine medicine NOUN dti-1423 50 59 . . PUNCT dti-1423 51 1 using use VERB dti-1423 51 2 the the DET dti-1423 51 3 experimental experimental ADJ dti-1423 51 4 procedure procedure NOUN dti-1423 51 5 described describe VERB dti-1423 51 6 above above ADV dti-1423 51 7 , , PUNCT dti-1423 51 8 we we PRON dti-1423 51 9 found find VERB dti-1423 51 10 that that SCONJ dti-1423 51 11 a a DET dti-1423 51 12 single single ADJ dti-1423 51 13 administration administration NOUN dti-1423 51 14 of of ADP dti-1423 51 15 meth meth NOUN dti-1423 51 16 ( ( PUNCT dti-1423 51 17 5 5 NUM dti-1423 51 18     SPACE dti-1423 51 19 mg mg PROPN dti-1423 51 20 / / SYM dti-1423 51 21 kg kg PROPN dti-1423 51 22 ) ) PUNCT dti-1423 51 23 induces induce VERB dti-1423 51 24 stereotypical stereotypical ADJ dti-1423 51 25 sniffing sniffing NOUN dti-1423 51 26 , , PUNCT dti-1423 51 27 while while SCONJ dti-1423 51 28 stereotypical stereotypical ADJ dti-1423 51 29 biting biting NOUN dti-1423 51 30 is be AUX dti-1423 51 31 predominantly predominantly ADV dti-1423 51 32 observed observe VERB dti-1423 51 33 at at ADP dti-1423 51 34 10 10 NUM dti-1423 51 35     SPACE dti-1423 51 36 mg mg PROPN dti-1423 51 37 / / SYM dti-1423 51 38 kg kg PROPN dti-1423 51 39 meth.33,35 meth.33,35 ADJ dti-1423 51 40 another another DET dti-1423 51 41 group group NOUN dti-1423 51 42 reported report VERB dti-1423 51 43 that that SCONJ dti-1423 51 44 a a DET dti-1423 51 45 single single ADJ dti-1423 51 46 administration administration NOUN dti-1423 51 47 of of ADP dti-1423 51 48 meth meth NOUN dti-1423 51 49 ( ( PUNCT dti-1423 51 50 20 20 NUM dti-1423 51 51     SPACE dti-1423 51 52 mg mg PROPN dti-1423 51 53 / / SYM dti-1423 51 54 kg kg PROPN dti-1423 51 55 ) ) PUNCT dti-1423 51 56 induces induce VERB dti-1423 51 57 repetitive repetitive ADJ dti-1423 51 58 self self NOUN dti-1423 51 59 - - PUNCT dti-1423 51 60 injurious injurious ADJ dti-1423 51 61 behavior.31,37 behavior.31,37 NOUN dti-1423 51 62 in in ADP dti-1423 51 63 line line NOUN dti-1423 51 64 with with ADP dti-1423 51 65 these these DET dti-1423 51 66 observations observation NOUN dti-1423 51 67 , , PUNCT dti-1423 51 68 meth meth NOUN dti-1423 51 69 - - PUNCT dti-1423 51 70 induced induce VERB dti-1423 51 71 stereotypical stereotypical ADJ dti-1423 51 72 biting biting NOUN dti-1423 51 73 appears appear VERB dti-1423 51 74 to to PART dti-1423 51 75 be be AUX dti-1423 51 76 a a DET dti-1423 51 77 more more ADV dti-1423 51 78 severe severe ADJ dti-1423 51 79 symptom symptom NOUN dti-1423 51 80 than than ADP dti-1423 51 81 stereotypical stereotypical ADJ dti-1423 51 82 sniffing sniffing NOUN dti-1423 51 83 as as ADP dti-1423 51 84 an an DET dti-1423 51 85 animal animal NOUN dti-1423 51 86 model model NOUN dti-1423 51 87 of of ADP dti-1423 51 88 meth meth NOUN dti-1423 51 89 overdose overdose ADV dti-1423 51 90 . . PUNCT dti-1423 52 1 possible possible ADJ dti-1423 52 2 pharmacological pharmacological ADJ dti-1423 52 3 properties property NOUN dti-1423 52 4 of of ADP dti-1423 52 5 compounds compound NOUN dti-1423 52 6 that that PRON dti-1423 52 7 will will AUX dti-1423 52 8 be be AUX dti-1423 52 9 effective effective ADJ dti-1423 52 10 for for ADP dti-1423 52 11 meth meth NOUN dti-1423 52 12 overdose overdose NOUN dti-1423 52 13 should should AUX dti-1423 52 14 ( ( PUNCT dti-1423 52 15 1 1 X dti-1423 52 16 ) ) PUNCT dti-1423 52 17 inhibit inhibit VERB dti-1423 52 18 meth meth NOUN dti-1423 52 19 - - PUNCT dti-1423 52 20 induced induce VERB dti-1423 52 21 stereotypical stereotypical ADJ dti-1423 52 22 biting bite VERB dti-1423 52 23 or or CCONJ dti-1423 52 24 ( ( PUNCT dti-1423 52 25 2 2 NUM dti-1423 52 26 ) ) PUNCT dti-1423 52 27 shift shift NOUN dti-1423 52 28 stereotypical stereotypical ADJ dti-1423 52 29 biting bite VERB dti-1423 52 30 to to ADP dti-1423 52 31 sniffing sniff VERB dti-1423 52 32 ( ( PUNCT dti-1423 52 33 eg eg NOUN dti-1423 52 34 , , PUNCT dti-1423 52 35 a a DET dti-1423 52 36 leftward leftward NOUN dti-1423 52 37 shift shift NOUN dti-1423 52 38 in in ADP dti-1423 52 39 the the DET dti-1423 52 40 meth meth NOUN dti-1423 52 41 dose dose VERB dti-1423 52 42 – – PUNCT dti-1423 52 43 response response NOUN dti-1423 52 44 relationship relationship NOUN dti-1423 52 45 , , PUNCT dti-1423 52 46 producing produce VERB dti-1423 52 47 less less ADV dti-1423 52 48 severe severe ADJ dti-1423 52 49 stereotypies stereotypie NOUN dti-1423 52 50 ) ) PUNCT dti-1423 52 51 . . PUNCT dti-1423 53 1 using use VERB dti-1423 53 2 this this DET dti-1423 53 3 approach approach NOUN dti-1423 53 4 , , PUNCT dti-1423 53 5 we we PRON dti-1423 53 6 investigated investigate VERB dti-1423 53 7 a a DET dti-1423 53 8 possible possible ADJ dti-1423 53 9 involvement involvement NOUN dti-1423 53 10 of of ADP dti-1423 53 11 brain brain NOUN dti-1423 53 12 histaminergic histaminergic ADJ dti-1423 53 13 neurons neuron NOUN dti-1423 53 14 in in ADP dti-1423 53 15 meth meth NOUN dti-1423 53 16 - - PUNCT dti-1423 53 17 induced induce VERB dti-1423 53 18 stereotypical stereotypical ADJ dti-1423 53 19 behavior behavior NOUN dti-1423 53 20 , , PUNCT dti-1423 53 21 as as ADP dti-1423 53 22 a a DET dti-1423 53 23 way way NOUN dti-1423 53 24 to to PART dti-1423 53 25 approach approach VERB dti-1423 53 26 potential potential ADJ dti-1423 53 27 novel novel NOUN dti-1423 53 28 treatments treatment NOUN dti-1423 53 29 for for ADP dti-1423 53 30 meth meth NOUN dti-1423 53 31 overdose overdose NOUN dti-1423 53 32 . . PUNCT dti-1423 54 1 brain brain NOUN dti-1423 54 2 histaminergic histaminergic ADJ dti-1423 54 3 systems system NOUN dti-1423 54 4 : : PUNCT dti-1423 54 5 potential potential ADJ dti-1423 54 6 roles role NOUN dti-1423 54 7 in in ADP dti-1423 54 8 drug drug NOUN dti-1423 54 9 addiction addiction NOUN dti-1423 54 10 , , PUNCT dti-1423 54 11 drug drug NOUN dti-1423 54 12 abuse abuse NOUN dti-1423 54 13 , , PUNCT dti-1423 54 14 and and CCONJ dti-1423 54 15 drug drug NOUN dti-1423 54 16 overdose overdose NOUN dti-1423 54 17 histamine histamine NOUN dti-1423 54 18 is be AUX dti-1423 54 19 a a DET dti-1423 54 20 biogenic biogenic ADJ dti-1423 54 21 amine amine NOUN dti-1423 54 22 produced produce VERB dti-1423 54 23 by by ADP dti-1423 54 24 the the DET dti-1423 54 25 body body NOUN dti-1423 54 26 and and CCONJ dti-1423 54 27 plays play VERB dti-1423 54 28 major major ADJ dti-1423 54 29 roles role NOUN dti-1423 54 30 in in ADP dti-1423 54 31 allergic allergic ADJ dti-1423 54 32 reactions reaction NOUN dti-1423 54 33 and and CCONJ dti-1423 54 34 secretion secretion NOUN dti-1423 54 35 of of ADP dti-1423 54 36 gastric gastric ADJ dti-1423 54 37 acid.42–44 acid.42–44 SCONJ dti-1423 54 38 it it PRON dti-1423 54 39 is be AUX dti-1423 54 40 also also ADV dti-1423 54 41 released release VERB dti-1423 54 42 by by ADP dti-1423 54 43 neurons neuron NOUN dti-1423 54 44 that that PRON dti-1423 54 45 originate originate VERB dti-1423 54 46 from from ADP dti-1423 54 47 the the DET dti-1423 54 48 tuberomammillary tuberomammillary ADJ dti-1423 54 49 nucleus nucleus NOUN dti-1423 54 50 of of ADP dti-1423 54 51 the the DET dti-1423 54 52 posterior posterior ADJ dti-1423 54 53 hypothalamus hypothalamus NOUN dti-1423 54 54 and and CCONJ dti-1423 54 55 project project NOUN dti-1423 54 56 to to ADP dti-1423 54 57 various various ADJ dti-1423 54 58 brain brain NOUN dti-1423 54 59 areas,45,46 areas,45,46 PROPN dti-1423 54 60 suggesting suggest VERB dti-1423 54 61 that that SCONJ dti-1423 54 62 histamine histamine NOUN dti-1423 54 63 has have VERB dti-1423 54 64 crucial crucial ADJ dti-1423 54 65 roles role NOUN dti-1423 54 66 in in ADP dti-1423 54 67 the the DET dti-1423 54 68 central central ADJ dti-1423 54 69 nervous nervous ADJ dti-1423 54 70 system.47 system.47 PROPN dti-1423 54 71 brain brain NOUN dti-1423 54 72 histamine histamine NOUN dti-1423 54 73 is be AUX dti-1423 54 74 considered consider VERB dti-1423 54 75 to to PART dti-1423 54 76 be be AUX dti-1423 54 77 involved involve VERB dti-1423 54 78 in in ADP dti-1423 54 79 the the DET dti-1423 54 80 regulation regulation NOUN dti-1423 54 81 of of ADP dti-1423 54 82 arousal arousal NOUN dti-1423 54 83 , , PUNCT dti-1423 54 84 hormone hormone NOUN dti-1423 54 85 release release NOUN dti-1423 54 86 , , PUNCT dti-1423 54 87 feeding feeding NOUN dti-1423 54 88 / / SYM dti-1423 54 89 drinking drinking NOUN dti-1423 54 90 , , PUNCT dti-1423 54 91 and and CCONJ dti-1423 54 92 pain pain NOUN dti-1423 54 93 perception.48–54 perception.48–54 PROPN dti-1423 54 94 as as SCONJ dti-1423 54 95 shown show VERB dti-1423 54 96 in in ADP dti-1423 54 97 figure figure NOUN dti-1423 54 98 1 1 NUM dti-1423 54 99 , , PUNCT dti-1423 54 100 histamine histamine NOUN dti-1423 54 101 is be AUX dti-1423 54 102 synthesized synthesize VERB dti-1423 54 103 by by ADP dti-1423 54 104 decarboxylation decarboxylation NOUN dti-1423 54 105 of of ADP dti-1423 54 106 the the DET dti-1423 54 107 amino amino NOUN dti-1423 54 108 acid acid PROPN dti-1423 54 109 l l PROPN dti-1423 54 110 - - NOUN dti-1423 54 111 histidine histidine NOUN dti-1423 54 112 in in ADP dti-1423 54 113 a a DET dti-1423 54 114 reaction reaction NOUN dti-1423 54 115 catalyzed catalyze VERB dti-1423 54 116 by by ADP dti-1423 54 117 histidine histidine ADJ dti-1423 54 118 decarboxylase decarboxylase PROPN dti-1423 54 119 ( ( PUNCT dti-1423 54 120 hdc hdc NOUN dti-1423 54 121 ) ) PUNCT dti-1423 54 122 , , PUNCT dti-1423 54 123 stored store VERB dti-1423 54 124 in in ADP dti-1423 54 125 mast mast NOUN dti-1423 54 126 cells cell NOUN dti-1423 54 127 , , PUNCT dti-1423 54 128 basophils basophils PROPN dti-1423 54 129 , , PUNCT dti-1423 54 130 enterochromaffin enterochromaffin NOUN dti-1423 54 131 - - PUNCT dti-1423 54 132 like like ADJ dti-1423 54 133 cells cell NOUN dti-1423 54 134 , , PUNCT dti-1423 54 135 and and CCONJ dti-1423 54 136 histaminergic histaminergic ADJ dti-1423 54 137 neurons neuron NOUN dti-1423 54 138 , , PUNCT dti-1423 54 139 and and CCONJ dti-1423 54 140 released release VERB dti-1423 54 141 on on ADP dti-1423 54 142 stimulation stimulation NOUN dti-1423 54 143 . . PUNCT dti-1423 55 1 released release VERB dti-1423 55 2 histamine histamine NOUN dti-1423 55 3 in in ADP dti-1423 55 4 turn turn NOUN dti-1423 55 5 activates activate VERB dti-1423 55 6 histaminergic histaminergic ADJ dti-1423 55 7 receptors receptor NOUN dti-1423 55 8 , , PUNCT dti-1423 55 9 causing cause VERB dti-1423 55 10 physiological physiological ADJ dti-1423 55 11 reactions reaction NOUN dti-1423 55 12 . . PUNCT dti-1423 56 1 in in ADP dti-1423 56 2 brain brain NOUN dti-1423 56 3 , , PUNCT dti-1423 56 4 for for ADP dti-1423 56 5 termination termination NOUN dti-1423 56 6 of of ADP dti-1423 56 7 histaminergic histaminergic ADJ dti-1423 56 8 neurotransmission neurotransmission NOUN dti-1423 56 9 after after ADP dti-1423 56 10 activation activation NOUN dti-1423 56 11 of of ADP dti-1423 56 12 histamine histamine NOUN dti-1423 56 13 receptors receptor NOUN dti-1423 56 14 , , PUNCT dti-1423 56 15 histamine histamine NOUN dti-1423 56 16 is be AUX dti-1423 56 17 transferred transfer VERB dti-1423 56 18 from from ADP dti-1423 56 19 the the DET dti-1423 56 20 extracellular extracellular ADJ dti-1423 56 21 space space NOUN dti-1423 56 22 into into ADP dti-1423 56 23 cytoplasm cytoplasm NOUN dti-1423 56 24 by by ADP dti-1423 56 25 organic organic ADJ dti-1423 56 26 cation cation NOUN dti-1423 56 27 transporter transporter NOUN dti-1423 56 28 3 3 NUM dti-1423 56 29 and/or and/or CCONJ dti-1423 56 30 the the DET dti-1423 56 31 equilibrative equilibrative ADJ dti-1423 56 32 nucleoside nucleoside NOUN dti-1423 56 33 transporter transporter NOUN dti-1423 56 34 ( ( PUNCT dti-1423 56 35 ent4 ent4 PROPN dti-1423 56 36 ) ) PUNCT dti-1423 56 37 , , PUNCT dti-1423 56 38 and and CCONJ dti-1423 56 39 catabolized catabolize VERB dti-1423 56 40 by by ADP dti-1423 56 41 the the DET dti-1423 56 42 cytosolic cytosolic ADJ dti-1423 56 43 enzyme enzyme NOUN dti-1423 56 44 histamine histamine NOUN dti-1423 56 45 n n CCONJ dti-1423 56 46 - - PUNCT dti-1423 56 47 methyltransferase methyltransferase NOUN dti-1423 56 48 ( ( PUNCT dti-1423 56 49 hmt hmt NOUN dti-1423 56 50 ) ) PUNCT dti-1423 56 51 to to PART dti-1423 56 52 form form VERB dti-1423 56 53 n n CCONJ dti-1423 56 54 - - PUNCT dti-1423 56 55 methylhistamine methylhistamine NOUN dti-1423 56 56 , , PUNCT dti-1423 56 57 which which PRON dti-1423 56 58 is be AUX dti-1423 56 59 inactive inactive ADJ dti-1423 56 60 in in ADP dti-1423 56 61 the the DET dti-1423 56 62 histaminergic histaminergic ADJ dti-1423 56 63 system.55,56 system.55,56 NOUN dti-1423 56 64 hmt hmt PROPN dti-1423 56 65 is be AUX dti-1423 56 66 the the DET dti-1423 56 67 sole sole ADJ dti-1423 56 68 enzyme enzyme NOUN dti-1423 56 69 that that PRON dti-1423 56 70 degrades degrade VERB dti-1423 56 71 histamine histamine NOUN dti-1423 56 72 in in ADP dti-1423 56 73 brain,57,58 brain,57,58 PROPN dti-1423 56 74 whereas whereas SCONJ dti-1423 56 75 diamine diamine ADJ dti-1423 56 76 oxidase oxidase NOUN dti-1423 56 77 ( ( PUNCT dti-1423 56 78 dao dao NOUN dti-1423 56 79 ; ; PUNCT dti-1423 56 80 histaminase histaminase PROPN dti-1423 56 81 ) ) PUNCT dti-1423 56 82 catabolizes catabolize VERB dti-1423 56 83 histamine histamine NOUN dti-1423 56 84 in in ADP dti-1423 56 85 peripheral peripheral ADJ dti-1423 56 86 tissues.49,59 tissues.49,59 NOUN dti-1423 56 87 it it PRON dti-1423 56 88 is be AUX dti-1423 56 89 noted note VERB dti-1423 56 90 that that SCONJ dti-1423 56 91 both both PRON dti-1423 56 92 hmt hmt PROPN dti-1423 56 93 mrna mrna NOUN dti-1423 56 94 and and CCONJ dti-1423 56 95 hmt hmt NOUN dti-1423 56 96 - - PUNCT dti-1423 56 97 like like ADJ dti-1423 56 98 immunoreactivity immunoreactivity NOUN dti-1423 56 99 are be AUX dti-1423 56 100 expressed express VERB dti-1423 56 101 in in ADP dti-1423 56 102 mouse mouse NOUN dti-1423 56 103 stomach57,58 stomach57,58 NOUN dti-1423 56 104 and and CCONJ dti-1423 56 105 that that SCONJ dti-1423 56 106 the the DET dti-1423 56 107 urinary urinary ADJ dti-1423 56 108 excretions excretion NOUN dti-1423 56 109 of of ADP dti-1423 56 110 histamine histamine NOUN dti-1423 56 111 and and CCONJ dti-1423 56 112 n n DET dti-1423 56 113 t t PROPN dti-1423 56 114 - - PUNCT dti-1423 56 115 methylhistamine methylhistamine PROPN dti-1423 56 116 are be AUX dti-1423 56 117 affected affect VERB dti-1423 56 118 by by ADP dti-1423 56 119 food food NOUN dti-1423 56 120 intake intake NOUN dti-1423 56 121 in in ADP dti-1423 56 122 human human PROPN dti-1423 56 123 beings;60 beings;60 PROPN dti-1423 56 124 there there PRON dti-1423 56 125 is be VERB dti-1423 56 126 a a DET dti-1423 56 127 possibility possibility NOUN dti-1423 56 128 that that SCONJ dti-1423 56 129 hmt hmt PROPN dti-1423 56 130 might might AUX dti-1423 56 131 , , PUNCT dti-1423 56 132 at at ADP dti-1423 56 133 least least ADJ dti-1423 56 134 in in ADP dti-1423 56 135 part part NOUN dti-1423 56 136 , , PUNCT dti-1423 56 137 function function VERB dti-1423 56 138 in in ADP dti-1423 56 139 peripherally peripherally ADV dti-1423 56 140 . . PUNCT dti-1423 57 1 there there PRON dti-1423 57 2 is be VERB dti-1423 57 3 evidence evidence NOUN dti-1423 57 4 that that SCONJ dti-1423 57 5 some some DET dti-1423 57 6 drugs drug NOUN dti-1423 57 7 of of ADP dti-1423 57 8 abuse abuse NOUN dti-1423 57 9 ( ( PUNCT dti-1423 57 10 meth meth NOUN dti-1423 57 11 , , PUNCT dti-1423 57 12 ethanol ethanol NOUN dti-1423 57 13 , , PUNCT dti-1423 57 14 and and CCONJ dti-1423 57 15 caffeine caffeine NOUN dti-1423 57 16 ) ) PUNCT dti-1423 57 17 , , PUNCT dti-1423 57 18 acting act VERB dti-1423 57 19 through through ADP dti-1423 57 20 quite quite ADV dti-1423 57 21 different different ADJ dti-1423 57 22 initial initial ADJ dti-1423 57 23 molecular molecular ADJ dti-1423 57 24 targets target NOUN dti-1423 57 25 , , PUNCT dti-1423 57 26 release release VERB dti-1423 57 27 histamine histamine NOUN dti-1423 57 28 and and CCONJ dti-1423 57 29 increase increase VERB dti-1423 57 30 endogenous endogenous ADJ dti-1423 57 31 histamine histamine NOUN dti-1423 57 32 levels level NOUN dti-1423 57 33 in in ADP dti-1423 57 34 brain.61–65 brain.61–65 PRON dti-1423 57 35 what what PRON dti-1423 57 36 is be AUX dti-1423 57 37 the the DET dti-1423 57 38 role role NOUN dti-1423 57 39 of of ADP dti-1423 57 40 released release VERB dti-1423 57 41 histamine histamine NOUN dti-1423 57 42 by by ADP dti-1423 57 43 these these DET dti-1423 57 44 drugs drug NOUN dti-1423 57 45 in in ADP dti-1423 57 46 drug drug NOUN dti-1423 57 47 abuse abuse NOUN dti-1423 57 48 and and CCONJ dti-1423 57 49 addiction addiction NOUN dti-1423 57 50 ? ? PUNCT dti-1423 58 1 there there PRON dti-1423 58 2 are be VERB dti-1423 58 3 two two NUM dti-1423 58 4 main main ADJ dti-1423 58 5 possibilities possibility NOUN dti-1423 58 6 : : PUNCT dti-1423 58 7 ( ( PUNCT dti-1423 58 8 1 1 X dti-1423 58 9 ) ) PUNCT dti-1423 58 10 that that PRON dti-1423 58 11 histamine histamine NOUN dti-1423 58 12 contributes contribute VERB dti-1423 58 13 to to ADP dti-1423 58 14 the the DET dti-1423 58 15 addictive addictive ADJ dti-1423 58 16 or or CCONJ dti-1423 58 17 adverse adverse ADJ dti-1423 58 18 effects effect NOUN dti-1423 58 19 associated associate VERB dti-1423 58 20 with with ADP dti-1423 58 21 these these DET dti-1423 58 22 drugs drug NOUN dti-1423 58 23 or or CCONJ dti-1423 58 24 ( ( PUNCT dti-1423 58 25 2 2 NUM dti-1423 58 26 ) ) PUNCT dti-1423 58 27     SPACE dti-1423 58 28 that that DET dti-1423 58 29 histamine histamine NOUN dti-1423 58 30 release release NOUN dti-1423 58 31 acts act VERB dti-1423 58 32 in in ADP dti-1423 58 33 opposition opposition NOUN dti-1423 58 34 to to ADP dti-1423 58 35 those those DET dti-1423 58 36 effects effect NOUN dti-1423 58 37 and and CCONJ dti-1423 58 38 is be AUX dti-1423 58 39 part part NOUN dti-1423 58 40 of of ADP dti-1423 58 41 a a DET dti-1423 58 42 homeostatic homeostatic ADJ dti-1423 58 43 counterreaction counterreaction NOUN dti-1423 58 44 . . PUNCT dti-1423 59 1 supporting support VERB dti-1423 59 2 this this DET dti-1423 59 3 latter latter ADJ dti-1423 59 4 idea idea NOUN dti-1423 59 5 , , PUNCT dti-1423 59 6 chandorkar chandorkar NOUN dti-1423 59 7 and and CCONJ dti-1423 59 8 http://www.la-press.com http://www.la-press.com NOUN dti-1423 59 9 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1423 59 10 treatment treatment NOUN dti-1423 59 11 for for ADP dti-1423 59 12 methamphetamine methamphetamine NOUN dti-1423 59 13 overdose overdose ADP dti-1423 59 14 3drug 3drug NUM dti-1423 59 15 target target NOUN dti-1423 59 16 insights insight NOUN dti-1423 59 17 2016:10 2016:10 NUM dti-1423 59 18 coworkers coworker NOUN dti-1423 59 19 demonstrated demonstrate VERB dti-1423 59 20 that that SCONJ dti-1423 59 21 intraperitoneal intraperitoneal ADJ dti-1423 59 22 administration administration NOUN dti-1423 59 23 of of ADP dti-1423 59 24 high high ADJ dti-1423 59 25 doses dose NOUN dti-1423 59 26 of of ADP dti-1423 59 27 l l NOUN dti-1423 59 28 - - NOUN dti-1423 59 29 histidine histidine ADJ dti-1423 59 30 , , PUNCT dti-1423 59 31 a a DET dti-1423 59 32 substrate substrate NOUN dti-1423 59 33 for for ADP dti-1423 59 34 histamine histamine NOUN dti-1423 59 35 synthesis synthesis NOUN dti-1423 59 36 ( ( PUNCT dti-1423 59 37 fig fig NOUN dti-1423 59 38 . . NOUN dti-1423 59 39 1 1 NUM dti-1423 59 40 ) ) PUNCT dti-1423 59 41 , , PUNCT dti-1423 59 42 reduces reduce VERB dti-1423 59 43 methand methand NOUN dti-1423 59 44 apomorphine apomorphine NOUN dti-1423 59 45 - - PUNCT dti-1423 59 46 induced induce VERB dti-1423 59 47 stereotypical stereotypical ADJ dti-1423 59 48 behaviors behavior NOUN dti-1423 59 49 in in ADP dti-1423 59 50 mice mouse NOUN dti-1423 59 51 , , PUNCT dti-1423 59 52 suggesting suggest VERB dti-1423 59 53 that that SCONJ dti-1423 59 54 increased increase VERB dti-1423 59 55 levels level NOUN dti-1423 59 56 of of ADP dti-1423 59 57 histamine histamine NOUN dti-1423 59 58 in in ADP dti-1423 59 59 brain brain NOUN dti-1423 59 60 suppress suppress VERB dti-1423 59 61 abnormal abnormal ADJ dti-1423 59 62 behaviors behavior NOUN dti-1423 59 63 associated associate VERB dti-1423 59 64 with with ADP dti-1423 59 65 administration administration NOUN dti-1423 59 66 of of ADP dti-1423 59 67 high high ADJ dti-1423 59 68 doses dose NOUN dti-1423 59 69 of of ADP dti-1423 59 70 these these DET dti-1423 59 71 drugs.36,66 drugs.36,66 ADJ dti-1423 59 72 observation observation NOUN dti-1423 59 73 reported report VERB dti-1423 59 74 by by ADP dti-1423 59 75 ito ito PROPN dti-1423 59 76 et et PROPN dti-1423 59 77 al al PROPN dti-1423 59 78 support support PROPN dti-1423 59 79 chandorkar chandorkar NOUN dti-1423 59 80 ’s ’s PART dti-1423 59 81 perspective perspective NOUN dti-1423 59 82 , , PUNCT dti-1423 59 83 finding find VERB dti-1423 59 84 that that SCONJ dti-1423 59 85 pretreatment pretreatment NOUN dti-1423 59 86 with with ADP dti-1423 59 87 l l NOUN dti-1423 59 88 - - NOUN dti-1423 59 89 histidine histidine NOUN dti-1423 59 90 inhibits inhibit VERB dti-1423 59 91 meth meth NOUN dti-1423 59 92 - - PUNCT dti-1423 59 93 induced induce VERB dti-1423 59 94 stereotypy stereotypy NOUN dti-1423 59 95 and and CCONJ dti-1423 59 96 behavioral behavioral ADJ dti-1423 59 97 sensitization sensitization NOUN dti-1423 59 98 in in ADP dti-1423 59 99 rats rat NOUN dti-1423 59 100 , , PUNCT dti-1423 59 101 while while SCONJ dti-1423 59 102 stereotypy stereotypy PROPN dti-1423 59 103 and and CCONJ dti-1423 59 104 behavioral behavioral ADJ dti-1423 59 105 sensitization sensitization NOUN dti-1423 59 106 are be AUX dti-1423 59 107 exacerbated exacerbate VERB dti-1423 59 108 when when SCONJ dti-1423 59 109 rats rat NOUN dti-1423 59 110 were be AUX dti-1423 59 111 pretreated pretreate VERB dti-1423 59 112 with with ADP dti-1423 59 113 a a DET dti-1423 59 114 - - PUNCT dti-1423 59 115 fluoromethylhistidine fluoromethylhistidine NOUN dti-1423 59 116 , , PUNCT dti-1423 59 117 an an DET dti-1423 59 118 irreversible irreversible ADJ dti-1423 59 119 inhibitor inhibitor NOUN dti-1423 59 120 of of ADP dti-1423 59 121 hdc hdc NOUN dti-1423 59 122 ( ( PUNCT dti-1423 59 123 fig fig NOUN dti-1423 59 124 . . NOUN dti-1423 60 1 1 1 NUM dti-1423 60 2 ) ) PUNCT dti-1423 60 3 that that PRON dti-1423 60 4 reduces reduce VERB dti-1423 60 5 brain brain NOUN dti-1423 60 6 histamine histamine NOUN dti-1423 60 7 levels.67 levels.67 NOUN dti-1423 60 8 in in ADP dti-1423 60 9 line line NOUN dti-1423 60 10 with with ADP dti-1423 60 11 these these DET dti-1423 60 12 observations observation NOUN dti-1423 60 13 , , PUNCT dti-1423 60 14 it it PRON dti-1423 60 15 is be AUX dti-1423 60 16 likely likely ADJ dti-1423 60 17 that that SCONJ dti-1423 60 18 increasing increase VERB dti-1423 60 19 levels level NOUN dti-1423 60 20 of of ADP dti-1423 60 21 brain brain NOUN dti-1423 60 22 histamine histamine NOUN dti-1423 60 23 may may AUX dti-1423 60 24 attenuate attenuate VERB dti-1423 60 25 meth meth NOUN dti-1423 60 26 - - PUNCT dti-1423 60 27 induced induce VERB dti-1423 60 28 behavioral behavioral ADJ dti-1423 60 29 effects effect NOUN dti-1423 60 30 . . PUNCT dti-1423 61 1 this this PRON dti-1423 61 2 is be AUX dti-1423 61 3 supported support VERB dti-1423 61 4 by by ADP dti-1423 61 5 the the DET dti-1423 61 6 evidence evidence NOUN dti-1423 61 7 that that SCONJ dti-1423 61 8 the the DET dti-1423 61 9 l l ADJ dti-1423 61 10 - - ADJ dti-1423 61 11 histidine histidine ADJ dti-1423 61 12 effects effect NOUN dti-1423 61 13 were be AUX dti-1423 61 14 blocked block VERB dti-1423 61 15 by by ADP dti-1423 61 16 treatment treatment NOUN dti-1423 61 17 with with ADP dti-1423 61 18 brain brain NOUN dti-1423 61 19 - - PUNCT dti-1423 61 20 penetrating penetrate VERB dti-1423 61 21 histamine histamine NOUN dti-1423 61 22 h1 h1 PROPN dti-1423 61 23 / / SYM dti-1423 61 24 h2 h2 NOUN dti-1423 61 25 receptor receptor NOUN dti-1423 61 26 antagonists.67 antagonists.67 PROPN dti-1423 61 27 hmt hmt PROPN dti-1423 61 28 : : PUNCT dti-1423 61 29 a a DET dti-1423 61 30 key key ADJ dti-1423 61 31 enzyme enzyme NOUN dti-1423 61 32 regulating regulate VERB dti-1423 61 33 high high ADJ dti-1423 61 34 - - PUNCT dti-1423 61 35 dose dose NOUN dti-1423 61 36 effects effect NOUN dti-1423 61 37 of of ADP dti-1423 61 38 meth meth NOUN dti-1423 61 39 as as SCONJ dti-1423 61 40 described describe VERB dti-1423 61 41 above above ADV dti-1423 61 42 , , PUNCT dti-1423 61 43 compounds compound VERB dti-1423 61 44 such such ADJ dti-1423 61 45 as as ADP dti-1423 61 46 l l NOUN dti-1423 61 47 - - NOUN dti-1423 61 48 histidine histidine ADJ dti-1423 61 49 and and CCONJ dti-1423 61 50 a a DET dti-1423 61 51 - - PUNCT dti-1423 61 52 fluoromethylhistidine fluoromethylhistidine NOUN dti-1423 61 53 are be AUX dti-1423 61 54 useful useful ADJ dti-1423 61 55 for for ADP dti-1423 61 56 the the DET dti-1423 61 57 increase increase NOUN dti-1423 61 58 or or CCONJ dti-1423 61 59 decrease decrease NOUN dti-1423 61 60 in in ADP dti-1423 61 61 neuronal neuronal ADJ dti-1423 61 62 histamine histamine NOUN dti-1423 61 63 release release NOUN dti-1423 61 64 , , PUNCT dti-1423 61 65 resulting result VERB dti-1423 61 66 in in ADP dti-1423 61 67 increasing increase VERB dti-1423 61 68 or or CCONJ dti-1423 61 69 decreasing decrease VERB dti-1423 61 70 brain brain NOUN dti-1423 61 71 histamine histamine NOUN dti-1423 61 72 levels level NOUN dti-1423 61 73 , , PUNCT dti-1423 61 74 respectively.66–71 respectively.66–71 VERB dti-1423 61 75 however however ADV dti-1423 61 76 , , PUNCT dti-1423 61 77 these these DET dti-1423 61 78 compounds compound NOUN dti-1423 61 79 potentially potentially ADV dti-1423 61 80 alter alter VERB dti-1423 61 81 the the DET dti-1423 61 82 levels level NOUN dti-1423 61 83 of of ADP dti-1423 61 84 histamines histamine NOUN dti-1423 61 85 throughout throughout ADP dti-1423 61 86 the the DET dti-1423 61 87 body body NOUN dti-1423 61 88 . . PUNCT dti-1423 62 1 by by ADP dti-1423 62 2 contrast contrast NOUN dti-1423 62 3 , , PUNCT dti-1423 62 4 inhibition inhibition NOUN dti-1423 62 5 of of ADP dti-1423 62 6 hmt hmt NOUN dti-1423 62 7 activity activity NOUN dti-1423 62 8 predominantly predominantly ADV dti-1423 62 9 modulates modulate VERB dti-1423 62 10 central central ADJ dti-1423 62 11 histaminergic histaminergic ADJ dti-1423 62 12 activity activity NOUN dti-1423 62 13 , , PUNCT dti-1423 62 14 while while SCONJ dti-1423 62 15 peripheral peripheral ADJ dti-1423 62 16 histaminergic histaminergic ADJ dti-1423 62 17 activity activity NOUN dti-1423 62 18 is be AUX dti-1423 62 19 affected affect VERB dti-1423 62 20 , , PUNCT dti-1423 62 21 to to ADP dti-1423 62 22 a a DET dti-1423 62 23 lesser less ADJ dti-1423 62 24 extent extent NOUN dti-1423 62 25 , , PUNCT dti-1423 62 26 by by ADP dti-1423 62 27 inhibiting inhibit VERB dti-1423 62 28 an an DET dti-1423 62 29 hmt hmt NOUN dti-1423 62 30 activity activity NOUN dti-1423 62 31 . . PUNCT dti-1423 63 1 at at ADP dti-1423 63 2 present present ADJ dti-1423 63 3 , , PUNCT dti-1423 63 4 there there PRON dti-1423 63 5 are be VERB dti-1423 63 6 no no DET dti-1423 63 7 compounds compound NOUN dti-1423 63 8 that that PRON dti-1423 63 9 increase increase VERB dti-1423 63 10 hmt hmt NOUN dti-1423 63 11 activity activity NOUN dti-1423 63 12 . . PUNCT dti-1423 64 1 several several ADJ dti-1423 64 2 hmt hmt NOUN dti-1423 64 3 inhibitors inhibitor NOUN dti-1423 64 4 are be AUX dti-1423 64 5 available available ADJ dti-1423 64 6 for for ADP dti-1423 64 7 research research NOUN dti-1423 64 8 purposes.72–74 purposes.72–74 PROPN dti-1423 64 9 the the DET dti-1423 64 10 dimaprit dimaprit PROPN dti-1423 64 11 analog analog NOUN dti-1423 64 12 skf skf PROPN dti-1423 64 13 91488 91488 NUM dti-1423 64 14 ( ( PUNCT dti-1423 64 15 s-[4-(n s-[4-(n NUM dti-1423 64 16 , , PUNCT dti-1423 64 17 n n CCONJ dti-1423 64 18 - - PUNCT dti-1423 64 19 dimethylamino)butyl]isothiourea dimethylamino)butyl]isothiourea NOUN dti-1423 64 20 ) ) PUNCT dti-1423 64 21 is be AUX dti-1423 64 22 one one NUM dti-1423 64 23 of of ADP dti-1423 64 24 the the DET dti-1423 64 25 most most ADV dti-1423 64 26 potent potent ADJ dti-1423 64 27 hmt hmt NOUN dti-1423 64 28 inhibitors inhibitor NOUN dti-1423 64 29 currently currently ADV dti-1423 64 30 known.74 known.74 VERB dti-1423 64 31 however however ADV dti-1423 64 32 , , PUNCT dti-1423 64 33 to to PART dti-1423 64 34 inhibit inhibit VERB dti-1423 64 35 hmt hmt NOUN dti-1423 64 36 activity activity NOUN dti-1423 64 37 in in ADP dti-1423 64 38 the the DET dti-1423 64 39 brain brain NOUN dti-1423 64 40 , , PUNCT dti-1423 64 41 skf skf PROPN dti-1423 64 42 91488 91488 NUM dti-1423 64 43 needs need VERB dti-1423 64 44 to to PART dti-1423 64 45 be be AUX dti-1423 64 46 administered administer VERB dti-1423 64 47 by by ADP dti-1423 64 48 an an DET dti-1423 64 49 intracerebroventricular intracerebroventricular ADJ dti-1423 64 50 route.65,75 route.65,75 NOUN dti-1423 64 51 intraperitoneal intraperitoneal PROPN dti-1423 64 52 administration administration NOUN dti-1423 64 53 of of ADP dti-1423 64 54 skf skf PROPN dti-1423 64 55 91488 91488 NUM dti-1423 64 56 does do AUX dti-1423 64 57 not not PART dti-1423 64 58 appear appear VERB dti-1423 64 59 to to PART dti-1423 64 60 affect affect VERB dti-1423 64 61 hmt hmt NOUN dti-1423 64 62 activity activity NOUN dti-1423 64 63 in in ADP dti-1423 64 64 the the DET dti-1423 64 65 brain brain NOUN dti-1423 64 66 , , PUNCT dti-1423 64 67 suggesting suggest VERB dti-1423 64 68 that that SCONJ dti-1423 64 69 the the DET dti-1423 64 70 compound compound NOUN dti-1423 64 71 does do AUX dti-1423 64 72 not not PART dti-1423 64 73 cross cross VERB dti-1423 64 74 the the DET dti-1423 64 75 brood brood NOUN dti-1423 64 76 – – PUNCT dti-1423 64 77 brain brain NOUN dti-1423 64 78 barrier.74 barrier.74 NOUN dti-1423 64 79 there there PRON dti-1423 64 80 are be VERB dti-1423 64 81 no no DET dti-1423 64 82 reports report NOUN dti-1423 64 83 of of ADP dti-1423 64 84 the the DET dti-1423 64 85 effects effect NOUN dti-1423 64 86 of of ADP dti-1423 64 87 skf skf PROPN dti-1423 64 88 91488 91488 NUM dti-1423 64 89 on on ADP dti-1423 64 90 rodent rodent ADJ dti-1423 64 91 behavior behavior NOUN dti-1423 64 92 except except SCONJ dti-1423 64 93 that that SCONJ dti-1423 64 94 by by ADP dti-1423 64 95 malmberg malmberg PROPN dti-1423 64 96 - - PUNCT dti-1423 64 97 aiello aiello PROPN dti-1423 64 98 et et NOUN dti-1423 64 99 al,75 al,75 NOUN dti-1423 64 100 which which PRON dti-1423 64 101 describes describe VERB dti-1423 64 102 that that DET dti-1423 64 103 intracerebroventricular intracerebroventricular ADJ dti-1423 64 104 administration administration NOUN dti-1423 64 105 of of ADP dti-1423 64 106 skf skf PROPN dti-1423 64 107 91488 91488 NUM dti-1423 64 108 produces produce VERB dti-1423 64 109 antinociceptive antinociceptive ADJ dti-1423 64 110 effects effect NOUN dti-1423 64 111 in in ADP dti-1423 64 112 hot hot ADJ dti-1423 64 113 plate plate NOUN dti-1423 64 114 , , PUNCT dti-1423 64 115 abdominal abdominal ADJ dti-1423 64 116 constriction constriction NOUN dti-1423 64 117 , , PUNCT dti-1423 64 118 and and CCONJ dti-1423 64 119 paw paw NOUN dti-1423 64 120 pressure pressure NOUN dti-1423 64 121 tests test NOUN dti-1423 64 122 ( ( PUNCT dti-1423 64 123 table table NOUN dti-1423 64 124 1 1 NUM dti-1423 64 125 ) ) PUNCT dti-1423 64 126 . . PUNCT dti-1423 65 1 these these DET dti-1423 65 2 observations observation NOUN dti-1423 65 3 suggest suggest VERB dti-1423 65 4 that that SCONJ dti-1423 65 5 skf skf PROPN dti-1423 65 6 91488 91488 NUM dti-1423 65 7 increases increase VERB dti-1423 65 8 brain brain NOUN dti-1423 65 9 histamine histamine NOUN dti-1423 65 10 levels level NOUN dti-1423 65 11 by by ADP dti-1423 65 12 inhibiting inhibit VERB dti-1423 65 13 an an DET dti-1423 65 14 hmt hmt NOUN dti-1423 65 15 activity activity NOUN dti-1423 65 16 resulting result VERB dti-1423 65 17 in in ADP dti-1423 65 18 antinociceptive antinociceptive ADJ dti-1423 65 19 effects effect NOUN dti-1423 65 20 by by ADP dti-1423 65 21 activating activate VERB dti-1423 65 22 central central ADJ dti-1423 65 23 histaminergic histaminergic ADJ dti-1423 65 24 neurotransmission52 neurotransmission52 NOUN dti-1423 65 25 and and CCONJ dti-1423 65 26 that that SCONJ dti-1423 65 27 hmt hmt NOUN dti-1423 65 28 inhibitors inhibitor NOUN dti-1423 65 29 may may AUX dti-1423 65 30 be be AUX dti-1423 65 31 used use VERB dti-1423 65 32 to to PART dti-1423 65 33 reveal reveal VERB dti-1423 65 34 important important ADJ dti-1423 65 35 roles role NOUN dti-1423 65 36 of of ADP dti-1423 65 37 central central ADJ dti-1423 65 38 histaminergic histaminergic ADJ dti-1423 65 39 system system NOUN dti-1423 65 40 . . PUNCT dti-1423 66 1 however however ADV dti-1423 66 2 , , PUNCT dti-1423 66 3 an an DET dti-1423 66 4 alternative alternative ADJ dti-1423 66 5 compound compound NOUN dti-1423 66 6 would would AUX dti-1423 66 7 be be AUX dti-1423 66 8 desirable desirable ADJ dti-1423 66 9 for for ADP dti-1423 66 10 both both CCONJ dti-1423 66 11 research research NOUN dti-1423 66 12 and and CCONJ dti-1423 66 13 clinical clinical ADJ dti-1423 66 14 applications application NOUN dti-1423 66 15 . . PUNCT dti-1423 67 1 in in ADP dti-1423 67 2 contrast contrast NOUN dti-1423 67 3 to to ADP dti-1423 67 4 the the DET dti-1423 67 5 limitations limitation NOUN dti-1423 67 6 of of ADP dti-1423 67 7 skf skf PROPN dti-1423 67 8 9148874 9148874 NUM dti-1423 67 9 for for ADP dti-1423 67 10 studies study NOUN dti-1423 67 11 of of ADP dti-1423 67 12 central central ADJ dti-1423 67 13 histamine histamine NOUN dti-1423 67 14 function function NOUN dti-1423 67 15 , , PUNCT dti-1423 67 16 metoprine metoprine NOUN dti-1423 67 17 ( ( PUNCT dti-1423 67 18 2,4 2,4 NUM dti-1423 67 19 - - PUNCT dti-1423 67 20 diamino-5(3′,4′-dichlorophenyl)-6 diamino-5(3′,4′-dichlorophenyl)-6 NOUN dti-1423 67 21 - - NOUN dti-1423 67 22 methylpyrimidine methylpyrimidine NOUN dti-1423 67 23 ; ; PUNCT dti-1423 67 24 formerly formerly ADV dti-1423 67 25 called call VERB dti-1423 67 26 bw bw PROPN dti-1423 67 27 197u 197u PROPN dti-1423 67 28 ) ) PUNCT dti-1423 67 29 , , PUNCT dti-1423 67 30 a a DET dti-1423 67 31 diaminopyrimidine diaminopyrimidine NOUN dti-1423 67 32 derivative derivative NOUN dti-1423 67 33 and and CCONJ dti-1423 67 34 potent potent ADJ dti-1423 67 35 hmt hmt NOUN dti-1423 67 36 inhibitor,73 inhibitor,73 NOUN dti-1423 67 37 readily readily ADV dti-1423 67 38 crosses cross VERB dti-1423 67 39 the the DET dti-1423 67 40 blood blood NOUN dti-1423 67 41 – – PUNCT dti-1423 67 42 brain brain NOUN dti-1423 67 43 barrier.76 barrier.76 NOUN dti-1423 67 44 thus thus ADV dti-1423 67 45 , , PUNCT dti-1423 67 46 this this DET dti-1423 67 47 compound compound NOUN dti-1423 67 48 can can AUX dti-1423 67 49 be be AUX dti-1423 67 50 administered administer VERB dti-1423 67 51 systemically systemically ADV dti-1423 67 52 in in ADP dti-1423 67 53 order order NOUN dti-1423 67 54 to to PART dti-1423 67 55 inhibit inhibit VERB dti-1423 67 56 the the DET dti-1423 67 57 hmt hmt NOUN dti-1423 67 58 activity activity NOUN dti-1423 67 59 in in ADP dti-1423 67 60 the the DET dti-1423 67 61 brain brain NOUN dti-1423 67 62 . . PUNCT dti-1423 68 1 intraperitoneal intraperitoneal ADJ dti-1423 68 2 administration administration NOUN dti-1423 68 3 of of ADP dti-1423 68 4 metoprine metoprine NOUN dti-1423 68 5 produces produce VERB dti-1423 68 6 various various ADJ dti-1423 68 7 behavioral behavioral ADJ dti-1423 68 8 effects effect NOUN dti-1423 68 9 , , PUNCT dti-1423 68 10 including include VERB dti-1423 68 11 decreases decrease NOUN dti-1423 68 12 in in ADP dti-1423 68 13 food food NOUN dti-1423 68 14 intake77 intake77 NOUN dti-1423 68 15 and and CCONJ dti-1423 68 16 increases increase VERB dti-1423 68 17 in in ADP dti-1423 68 18 water water NOUN dti-1423 68 19 consumption.78 consumption.78 VERB dti-1423 68 20 these these DET dti-1423 68 21 observations observation NOUN dti-1423 68 22 support support VERB dti-1423 68 23 a a DET dti-1423 68 24 hypothesis hypothesis NOUN dti-1423 68 25 that that PRON dti-1423 68 26 central central ADJ dti-1423 68 27 histaminergic histaminergic ADJ dti-1423 68 28 system system NOUN dti-1423 68 29 may may AUX dti-1423 68 30 involve involve VERB dti-1423 68 31 in in ADP dti-1423 68 32 the the DET dti-1423 68 33 regulation regulation NOUN dti-1423 68 34 of of ADP dti-1423 68 35 feeding/ feeding/ NUM dti-1423 68 36 drinking.54 drinking.54 NOUN dti-1423 68 37 studies study NOUN dti-1423 68 38 with with ADP dti-1423 68 39 metoprine metoprine NOUN dti-1423 68 40 also also ADV dti-1423 68 41 suggest suggest VERB dti-1423 68 42 that that SCONJ dti-1423 68 43 brain brain NOUN dti-1423 68 44 histaminergic histaminergic ADJ dti-1423 68 45 systems system NOUN dti-1423 68 46 may may AUX dti-1423 68 47 be be AUX dti-1423 68 48 involved involve VERB dti-1423 68 49 in in ADP dti-1423 68 50 mood mood NOUN dti-1423 68 51 and and CCONJ dti-1423 68 52 memory memory NOUN dti-1423 68 53 processes.79,80 processes.79,80 NOUN dti-1423 68 54 regarding regard VERB dti-1423 68 55 regulation regulation NOUN dti-1423 68 56 of of ADP dti-1423 68 57 drug drug NOUN dti-1423 68 58 abuse abuse NOUN dti-1423 68 59 - - PUNCT dti-1423 68 60 related relate VERB dti-1423 68 61 phenotypes phenotype NOUN dti-1423 68 62 by by ADP dti-1423 68 63 central central ADJ dti-1423 68 64 histaminergic histaminergic ADJ dti-1423 68 65 systems system NOUN dti-1423 68 66 , , PUNCT dti-1423 68 67 itoh itoh PROPN dti-1423 68 68 et et NOUN dti-1423 68 69 al81 al81 PROPN dti-1423 68 70 reported report VERB dti-1423 68 71 that that SCONJ dti-1423 68 72 pretreatment pretreatment NOUN dti-1423 68 73 with with ADP dti-1423 68 74 metoprine metoprine NOUN dti-1423 68 75 inhibited inhibit VERB dti-1423 68 76 meth meth NOUN dti-1423 68 77 - - PUNCT dti-1423 68 78 induced induce VERB dti-1423 68 79 hyperlocomotion hyperlocomotion NOUN dti-1423 68 80 in in ADP dti-1423 68 81 mice mouse NOUN dti-1423 68 82 , , PUNCT dti-1423 68 83 suggesting suggest VERB dti-1423 68 84 that that SCONJ dti-1423 68 85 central central ADJ dti-1423 68 86 histaminergic histaminergic ADJ dti-1423 68 87 systems system NOUN dti-1423 68 88 inhibit inhibit VERB dti-1423 68 89 meth meth NOUN dti-1423 68 90 - - PUNCT dti-1423 68 91 induced induce VERB dti-1423 68 92 behavioral behavioral ADJ dti-1423 68 93 effects effect NOUN dti-1423 68 94 . . PUNCT dti-1423 69 1 we we PRON dti-1423 69 2 have have AUX dti-1423 69 3 investigated investigate VERB dti-1423 69 4 whether whether SCONJ dti-1423 69 5 metoprine metoprine NOUN dti-1423 69 6 could could AUX dti-1423 69 7 inhibit inhibit VERB dti-1423 69 8 methinduced methinduce VERB dti-1423 69 9 stereotypy stereotypy PROPN dti-1423 69 10 , , PUNCT dti-1423 69 11 a a DET dti-1423 69 12 high high ADV dti-1423 69 13 - - PUNCT dti-1423 69 14 dose dose VERB dti-1423 69 15 behavioral behavioral ADJ dti-1423 69 16 effect effect NOUN dti-1423 69 17 intended intend VERB dti-1423 69 18 to to PART dti-1423 69 19 model model VERB dti-1423 69 20 meth meth NOUN dti-1423 69 21 overdose overdose ADV dti-1423 69 22 . . PUNCT dti-1423 70 1 pretreatment pretreatment NOUN dti-1423 70 2 with with ADP dti-1423 70 3 metoprine metoprine NOUN dti-1423 70 4 dose dose NOUN dti-1423 70 5 figure figure NOUN dti-1423 70 6 1 1 NUM dti-1423 70 7 . . PUNCT dti-1423 70 8 histamine histamine NOUN dti-1423 70 9 synthesis synthesis NOUN dti-1423 70 10 and and CCONJ dti-1423 70 11 catabolism catabolism NOUN dti-1423 70 12 in in ADP dti-1423 70 13 mammals mammal NOUN dti-1423 70 14 . . PUNCT dti-1423 71 1 abbreviations abbreviation NOUN dti-1423 71 2 : : PUNCT dti-1423 71 3 adh adh NOUN dti-1423 71 4 , , PUNCT dti-1423 71 5 alcohol alcohol NOUN dti-1423 71 6 dehydrogenase dehydrogenase NOUN dti-1423 71 7 ; ; PUNCT dti-1423 71 8 dao dao NOUN dti-1423 71 9 , , PUNCT dti-1423 71 10 diamine diamine NOUN dti-1423 71 11 oxidase oxidase NOUN dti-1423 71 12 ; ; PUNCT dti-1423 71 13 hdc hdc NUM dti-1423 71 14 , , PUNCT dti-1423 71 15 histidine histidine NOUN dti-1423 71 16 decarboxylase decarboxylase NOUN dti-1423 71 17 ; ; PUNCT dti-1423 71 18 hmt hmt NOUN dti-1423 71 19 , , PUNCT dti-1423 71 20 histamine histamine NOUN dti-1423 71 21 n n CCONJ dti-1423 71 22 - - PUNCT dti-1423 71 23 methyltransferase methyltransferase NOUN dti-1423 71 24 ; ; PUNCT dti-1423 71 25 mao mao PROPN dti-1423 71 26 , , PUNCT dti-1423 71 27 monoamine monoamine NOUN dti-1423 71 28 oxidase oxidase NOUN dti-1423 71 29 ; ; PUNCT dti-1423 71 30 sah sah PROPN dti-1423 71 31 , , PUNCT dti-1423 71 32 s s NOUN dti-1423 71 33 - - PUNCT dti-1423 71 34 adenosylhomosysteine adenosylhomosysteine NOUN dti-1423 71 35 ; ; PUNCT dti-1423 71 36 sam sam PROPN dti-1423 71 37 , , PUNCT dti-1423 71 38 s s NOUN dti-1423 71 39 - - PUNCT dti-1423 71 40 adenosylmethionine adenosylmethionine NOUN dti-1423 71 41 . . PUNCT dti-1423 71 42 http://www.la-press.com http://www.la-press.com X dti-1423 72 1 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1423 72 2 kitanaka kitanaka PROPN dti-1423 72 3 et et PROPN dti-1423 72 4 al al PROPN dti-1423 72 5 4 4 NUM dti-1423 72 6 drug drug NOUN dti-1423 72 7 target target NOUN dti-1423 72 8 insights insight NOUN dti-1423 72 9 2016:10 2016:10 NUM dti-1423 72 10 dependently dependently ADV dti-1423 72 11 decreased decrease VERB dti-1423 72 12 meth meth NOUN dti-1423 72 13 - - PUNCT dti-1423 72 14 induced induce VERB dti-1423 72 15 stereotypical stereotypical ADJ dti-1423 72 16 biting biting NOUN dti-1423 72 17 , , PUNCT dti-1423 72 18 while while SCONJ dti-1423 72 19 increasing increase VERB dti-1423 72 20 sniffing sniff VERB dti-1423 72 21 , , PUNCT dti-1423 72 22 suggesting suggest VERB dti-1423 72 23 that that SCONJ dti-1423 72 24 metoprine metoprine NOUN dti-1423 72 25 may may AUX dti-1423 72 26 ameliorate ameliorate VERB dti-1423 72 27 high high ADJ dti-1423 72 28 - - PUNCT dti-1423 72 29 dose dose NOUN dti-1423 72 30 meth meth NOUN dti-1423 72 31 - - PUNCT dti-1423 72 32 induced induce VERB dti-1423 72 33 symptoms symptom NOUN dti-1423 72 34 by by ADP dti-1423 72 35 producing produce VERB dti-1423 72 36 a a DET dti-1423 72 37 leftward leftward NOUN dti-1423 72 38 shift shift NOUN dti-1423 72 39 in in ADP dti-1423 72 40 meth meth NOUN dti-1423 72 41 behavioral behavioral ADJ dti-1423 72 42 effects effect NOUN dti-1423 72 43 ( ( PUNCT dti-1423 72 44 table table NOUN dti-1423 72 45 1).65 1).65 NUM dti-1423 72 46 the the DET dti-1423 72 47 inhibitory inhibitory ADJ dti-1423 72 48 effect effect NOUN dti-1423 72 49 of of ADP dti-1423 72 50 metoprine metoprine NOUN dti-1423 72 51 on on ADP dti-1423 72 52 meth meth NOUN dti-1423 72 53 - - PUNCT dti-1423 72 54 induced induce VERB dti-1423 72 55 stereotypical stereotypical ADJ dti-1423 72 56 biting biting NOUN dti-1423 72 57 is be AUX dti-1423 72 58 likely likely ADJ dti-1423 72 59 to to PART dti-1423 72 60 be be AUX dti-1423 72 61 mediated mediate VERB dti-1423 72 62 by by ADP dti-1423 72 63 histamine histamine NOUN dti-1423 72 64 h1 h1 NOUN dti-1423 72 65 ( ( PUNCT dti-1423 72 66 but but CCONJ dti-1423 72 67 not not PART dti-1423 72 68 h2 h2 NOUN dti-1423 72 69 / / SYM dti-1423 72 70 h3 h3 NOUN dti-1423 72 71 ) ) PUNCT dti-1423 72 72 receptors receptor NOUN dti-1423 72 73 located locate VERB dti-1423 72 74 in in ADP dti-1423 72 75 the the DET dti-1423 72 76 brain brain NOUN dti-1423 72 77 , , PUNCT dti-1423 72 78 since since SCONJ dti-1423 72 79 the the DET dti-1423 72 80 metoprine metoprine NOUN dti-1423 72 81 effect effect NOUN dti-1423 72 82 was be AUX dti-1423 72 83 blocked block VERB dti-1423 72 84 by by ADP dti-1423 72 85 coadministration coadministration NOUN dti-1423 72 86 of of ADP dti-1423 72 87 metoprine metoprine NOUN dti-1423 72 88 with with ADP dti-1423 72 89 brainpenetrating brainpenetrate VERB dti-1423 72 90 histamine histamine NOUN dti-1423 72 91 h1 h1 NOUN dti-1423 72 92 receptor receptor NOUN dti-1423 72 93 antagonists.65 antagonists.65 ADP dti-1423 72 94 it it PRON dti-1423 72 95 is be AUX dti-1423 72 96 likely likely ADJ dti-1423 72 97 that that SCONJ dti-1423 72 98 metoprine metoprine NOUN dti-1423 72 99 - - PUNCT dti-1423 72 100 activated activate VERB dti-1423 72 101 histaminergic histaminergic ADJ dti-1423 72 102 neurotransmission neurotransmission NOUN dti-1423 72 103 via via ADP dti-1423 72 104 central central ADJ dti-1423 72 105 histamine histamine NOUN dti-1423 72 106 h1 h1 NOUN dti-1423 72 107 receptors receptor NOUN dti-1423 72 108 accounted account VERB dti-1423 72 109 for for ADP dti-1423 72 110 the the DET dti-1423 72 111 attenuation attenuation NOUN dti-1423 72 112 of of ADP dti-1423 72 113 meth meth NOUN dti-1423 72 114 - - PUNCT dti-1423 72 115 induced induce VERB dti-1423 72 116 stereotypical stereotypical ADJ dti-1423 72 117 biting biting NOUN dti-1423 72 118 . . PUNCT dti-1423 73 1 this this PRON dti-1423 73 2 is be AUX dti-1423 73 3 supported support VERB dti-1423 73 4 by by ADP dti-1423 73 5 the the DET dti-1423 73 6 evidence evidence NOUN dti-1423 73 7 that that SCONJ dti-1423 73 8 ( ( PUNCT dti-1423 73 9 1 1 X dti-1423 73 10 ) ) PUNCT dti-1423 73 11 metoprine metoprine NOUN dti-1423 73 12 increased increase VERB dti-1423 73 13 histamine histamine NOUN dti-1423 73 14 levels level NOUN dti-1423 73 15 , , PUNCT dti-1423 73 16 but but CCONJ dti-1423 73 17 decreased decrease VERB dti-1423 73 18 n n PRON dti-1423 73 19 t t PROPN dti-1423 73 20 - - PUNCT dti-1423 73 21 methylhistamine methylhistamine ADJ dti-1423 73 22 levels level NOUN dti-1423 73 23 , , PUNCT dti-1423 73 24 in in ADP dti-1423 73 25 the the DET dti-1423 73 26 hypothalamus hypothalamus NOUN dti-1423 73 27 and and CCONJ dti-1423 73 28 ( ( PUNCT dti-1423 73 29 2 2 X dti-1423 73 30 ) ) PUNCT dti-1423 73 31 pretreatment pretreatment NOUN dti-1423 73 32 with with ADP dti-1423 73 33 l l NOUN dti-1423 73 34 - - NOUN dti-1423 73 35 histidine histidine NOUN dti-1423 73 36 , , PUNCT dti-1423 73 37 which which PRON dti-1423 73 38 increased increase VERB dti-1423 73 39 the the DET dti-1423 73 40 levels level NOUN dti-1423 73 41 of of ADP dti-1423 73 42 brain brain NOUN dti-1423 73 43 histamine histamine NOUN dti-1423 73 44 , , PUNCT dti-1423 73 45 also also ADV dti-1423 73 46 reduced reduce VERB dti-1423 73 47 the the DET dti-1423 73 48 frequency frequency NOUN dti-1423 73 49 of of ADP dti-1423 73 50 meth meth NOUN dti-1423 73 51 - - PUNCT dti-1423 73 52 induced induce VERB dti-1423 73 53 stereotypical stereotypical ADJ dti-1423 73 54 biting.82 biting.82 NOUN dti-1423 73 55 iwabuchi iwabuchi NOUN dti-1423 73 56 et et NOUN dti-1423 74 1 al83 al83 PROPN dti-1423 74 2 reported report VERB dti-1423 74 3 that that SCONJ dti-1423 74 4 meth meth NOUN dti-1423 74 5 - - PUNCT dti-1423 74 6 induced induce VERB dti-1423 74 7 locomotor locomotor NOUN dti-1423 74 8 hyperactivity hyperactivity NOUN dti-1423 74 9 and and CCONJ dti-1423 74 10 the the DET dti-1423 74 11 development development NOUN dti-1423 74 12 of of ADP dti-1423 74 13 behavioral behavioral ADJ dti-1423 74 14 sensitization sensitization NOUN dti-1423 74 15 were be AUX dti-1423 74 16 facilitated facilitate VERB dti-1423 74 17 more more ADV dti-1423 74 18 in in ADP dti-1423 74 19 the the DET dti-1423 74 20 histamine histamine NOUN dti-1423 74 21 h1 h1 PROPN dti-1423 74 22 / / SYM dti-1423 74 23 h2 h2 NOUN dti-1423 74 24 gene gene NOUN dti-1423 74 25 double double ADJ dti-1423 74 26 knockout knockout NOUN dti-1423 74 27 mice mouse NOUN dti-1423 74 28 than than ADP dti-1423 74 29 in in ADP dti-1423 74 30 the the DET dti-1423 74 31 wild wild ADJ dti-1423 74 32 - - PUNCT dti-1423 74 33 type type NOUN dti-1423 74 34 mice mouse NOUN dti-1423 74 35 , , PUNCT dti-1423 74 36 indicating indicate VERB dti-1423 74 37 that that SCONJ dti-1423 74 38 brain brain NOUN dti-1423 74 39 histaminergic histaminergic ADJ dti-1423 74 40 system system NOUN dti-1423 74 41 is be AUX dti-1423 74 42 negatively negatively ADV dti-1423 74 43 associated associate VERB dti-1423 74 44 with with ADP dti-1423 74 45 meth meth NOUN dti-1423 74 46 action action NOUN dti-1423 74 47 via via ADP dti-1423 74 48 histamine histamine NOUN dti-1423 74 49 h1 h1 PROPN dti-1423 74 50 / / SYM dti-1423 74 51 h2 h2 NOUN dti-1423 74 52 receptors receptor NOUN dti-1423 74 53 ( ( PUNCT dti-1423 74 54 see see VERB dti-1423 74 55 also also ADV dti-1423 74 56 reports report VERB dti-1423 74 57 by by ADP dti-1423 74 58 munzar munzar NOUN dti-1423 74 59 et et PROPN dti-1423 74 60 al,84,85 al,84,85 PROPN dti-1423 74 61 which which PRON dti-1423 74 62 described describe VERB dti-1423 74 63 a a DET dti-1423 74 64 possible possible ADJ dti-1423 74 65 involvement involvement NOUN dti-1423 74 66 of of ADP dti-1423 74 67 histamine histamine NOUN dti-1423 74 68 h3 h3 NOUN dti-1423 74 69 receptors receptor NOUN dti-1423 74 70 in in ADP dti-1423 74 71 meth meth NOUN dti-1423 74 72 - - PUNCT dti-1423 74 73 seeking seek VERB dti-1423 74 74 behavior behavior NOUN dti-1423 74 75 ) ) PUNCT dti-1423 74 76 . . PUNCT dti-1423 75 1 in in ADP dti-1423 75 2 addition addition NOUN dti-1423 75 3 , , PUNCT dti-1423 75 4 pretreatment pretreatment NOUN dti-1423 75 5 with with ADP dti-1423 75 6 histamine histamine NOUN dti-1423 75 7 h3 h3 NOUN dti-1423 75 8 receptor receptor NOUN dti-1423 75 9 ( ( PUNCT dti-1423 75 10 autoreceptor autoreceptor NOUN dti-1423 75 11 ) ) PUNCT dti-1423 75 12 agonists agonist NOUN dti-1423 75 13 such such ADJ dti-1423 75 14 as as ADP dti-1423 75 15 ( ( PUNCT dti-1423 75 16 r)-a r)-a NOUN dti-1423 75 17 - - ADJ dti-1423 75 18 methylhistamine methylhistamine ADJ dti-1423 75 19 , , PUNCT dti-1423 75 20 imetit imetit NOUN dti-1423 75 21 , , PUNCT dti-1423 75 22 and and CCONJ dti-1423 75 23 immepip immepip NOUN dti-1423 75 24 decreased decrease VERB dti-1423 75 25 hypothalamic hypothalamic ADJ dti-1423 75 26 histamine histamine NOUN dti-1423 75 27 levels level NOUN dti-1423 75 28 and and CCONJ dti-1423 75 29 increased increase VERB dti-1423 75 30 the the DET dti-1423 75 31 frequency frequency NOUN dti-1423 75 32 of of ADP dti-1423 75 33 meth meth NOUN dti-1423 75 34 - - PUNCT dti-1423 75 35 induced induce VERB dti-1423 75 36 stereotypical stereotypical ADJ dti-1423 75 37 biting.86 biting.86 NOUN dti-1423 75 38 moreover moreover ADV dti-1423 75 39 , , PUNCT dti-1423 75 40 it it PRON dti-1423 75 41 was be AUX dti-1423 75 42 noted note VERB dti-1423 75 43 that that SCONJ dti-1423 75 44 there there PRON dti-1423 75 45 was be VERB dti-1423 75 46 a a DET dti-1423 75 47 very very ADV dti-1423 75 48 strong strong ADJ dti-1423 75 49 negative negative ADJ dti-1423 75 50 correlation correlation NOUN dti-1423 75 51 ( ( PUNCT dti-1423 75 52 r r NOUN dti-1423 75 53     SPACE dti-1423 75 54 = = NOUN dti-1423 75 55     SPACE dti-1423 75 56 -0.918 -0.918 NOUN dti-1423 75 57 , , PUNCT dti-1423 75 58 p p X dti-1423 75 59     SPACE dti-1423 75 60 , , PUNCT dti-1423 75 61     SPACE dti-1423 75 62 0.001 0.001 NUM dti-1423 75 63 ) ) PUNCT dti-1423 75 64 between between ADP dti-1423 75 65 the the DET dti-1423 75 66 frequency frequency NOUN dti-1423 75 67 of of ADP dti-1423 75 68 meth meth NOUN dti-1423 75 69 - - PUNCT dti-1423 75 70 induced induce VERB dti-1423 75 71 stereotypical stereotypical ADJ dti-1423 75 72 biting bite VERB dti-1423 75 73 and and CCONJ dti-1423 75 74 hypothalamic hypothalamic ADJ dti-1423 75 75 histamine histamine NOUN dti-1423 75 76 levels level NOUN dti-1423 75 77 , , PUNCT dti-1423 75 78 suggesting suggest VERB dti-1423 75 79 that that DET dti-1423 75 80 activation activation NOUN dti-1423 75 81 of of ADP dti-1423 75 82 brain brain NOUN dti-1423 75 83 histaminergic histaminergic ADJ dti-1423 75 84 system system NOUN dti-1423 75 85 may may AUX dti-1423 75 86 suppress suppress VERB dti-1423 75 87 high high ADJ dti-1423 75 88 - - PUNCT dti-1423 75 89 dose dose NOUN dti-1423 75 90 behavioral behavioral ADJ dti-1423 75 91 effects effect NOUN dti-1423 75 92 of of ADP dti-1423 75 93 meth meth NOUN dti-1423 75 94 , , PUNCT dti-1423 75 95 and and CCONJ dti-1423 75 96 might might AUX dti-1423 75 97 consequently consequently ADV dti-1423 75 98 reduce reduce VERB dti-1423 75 99 high high ADJ dti-1423 75 100 - - PUNCT dti-1423 75 101 dose dose NOUN dti-1423 75 102 effects effect NOUN dti-1423 75 103 associated associate VERB dti-1423 75 104 with with ADP dti-1423 75 105 the the DET dti-1423 75 106 progression progression NOUN dti-1423 75 107 to to ADP dti-1423 75 108 drug drug NOUN dti-1423 75 109 dependence dependence NOUN dti-1423 75 110 and and CCONJ dti-1423 75 111 acute acute ADJ dti-1423 75 112 overdose.87 overdose.87 NOUN dti-1423 75 113 hmt hmt NOUN dti-1423 75 114 inhibitors inhibitor NOUN dti-1423 75 115 : : PUNCT dti-1423 75 116 candidate candidate NOUN dti-1423 75 117 compounds compound NOUN dti-1423 75 118 of of ADP dti-1423 75 119     SPACE dti-1423 75 120 treatment treatment NOUN dti-1423 75 121 for for ADP dti-1423 75 122 meth meth NOUN dti-1423 75 123 overdose overdose ADP dti-1423 75 124 no no DET dti-1423 75 125 agents agent NOUN dti-1423 75 126 that that PRON dti-1423 75 127 modulate modulate VERB dti-1423 75 128 histaminergic histaminergic ADJ dti-1423 75 129 system system NOUN dti-1423 75 130 other other ADJ dti-1423 75 131 than than ADP dti-1423 75 132 the the DET dti-1423 75 133 hmt hmt NOUN dti-1423 75 134 inhibitors inhibitor NOUN dti-1423 75 135 and and CCONJ dti-1423 75 136 l l NOUN dti-1423 75 137 - - NOUN dti-1423 75 138 histidine histidine NOUN dti-1423 75 139 have have AUX dti-1423 75 140 been be AUX dti-1423 75 141 reported report VERB dti-1423 75 142 to to PART dti-1423 75 143 ameliorate ameliorate VERB dti-1423 75 144 symptoms symptom NOUN dti-1423 75 145 of of ADP dti-1423 75 146 acute acute ADJ dti-1423 75 147 injections injection NOUN dti-1423 75 148 of of ADP dti-1423 75 149 high high ADJ dti-1423 75 150 - - PUNCT dti-1423 75 151 dose dose NOUN dti-1423 75 152 meth meth NOUN dti-1423 75 153 , , PUNCT dti-1423 75 154 although although SCONJ dti-1423 75 155 abt-239 abt-239 PROPN dti-1423 75 156 , , PUNCT dti-1423 75 157 an an DET dti-1423 75 158 antagonist antagonist NOUN dti-1423 75 159 selective selective NOUN dti-1423 75 160 for for ADP dti-1423 75 161 histamine histamine NOUN dti-1423 75 162 h3 h3 NOUN dti-1423 75 163 receptors receptor NOUN dti-1423 75 164 , , PUNCT dti-1423 75 165 attenuates attenuate VERB dti-1423 75 166 moderate moderate ADJ dti-1423 75 167 doses dose NOUN dti-1423 75 168 of of ADP dti-1423 75 169 meth meth NOUN dti-1423 75 170 - - PUNCT dti-1423 75 171 induced induce VERB dti-1423 75 172 locomotor locomotor NOUN dti-1423 75 173 hyperactivity.88 hyperactivity.88 NOUN dti-1423 75 174 in in ADP dti-1423 75 175 our our PRON dti-1423 75 176 preliminary preliminary ADJ dti-1423 75 177 experiments experiment NOUN dti-1423 75 178 , , PUNCT dti-1423 75 179 metoprine metoprine NOUN dti-1423 75 180 itself itself PRON dti-1423 75 181 did do AUX dti-1423 75 182 not not PART dti-1423 75 183 induce induce VERB dti-1423 75 184 an an DET dti-1423 75 185 anxiety anxiety NOUN dti-1423 75 186 - - PUNCT dti-1423 75 187 like like ADJ dti-1423 75 188 behavior behavior NOUN dti-1423 75 189 and and CCONJ dti-1423 75 190 memory memory NOUN dti-1423 75 191 impairments impairment NOUN dti-1423 75 192 in in ADP dti-1423 75 193 the the DET dti-1423 75 194 marble marble NOUN dti-1423 75 195 - - PUNCT dti-1423 75 196 burying bury VERB dti-1423 75 197 test test NOUN dti-1423 75 198 and and CCONJ dti-1423 75 199 y y ADJ dti-1423 75 200 - - PUNCT dti-1423 75 201 maze maze NOUN dti-1423 75 202 test test NOUN dti-1423 75 203 , , PUNCT dti-1423 75 204 respectively respectively ADV dti-1423 75 205 ( ( PUNCT dti-1423 75 206 s. s. PROPN dti-1423 75 207 okumura okumura PROPN dti-1423 75 208 and and CCONJ dti-1423 75 209 t. t. PROPN dti-1423 75 210 sakamoto sakamoto PROPN dti-1423 75 211 , , PUNCT dti-1423 75 212 unpublished unpublished ADJ dti-1423 75 213 observations observation NOUN dti-1423 75 214 ) ) PUNCT dti-1423 75 215 . . PUNCT dti-1423 76 1 therefore therefore ADV dti-1423 76 2 , , PUNCT dti-1423 76 3 metoprine metoprine NOUN dti-1423 76 4 is be AUX dti-1423 76 5 likely likely ADJ dti-1423 76 6 to to PART dti-1423 76 7 have have VERB dti-1423 76 8 limited limit VERB dti-1423 76 9 side side NOUN dti-1423 76 10 effects effect NOUN dti-1423 76 11 , , PUNCT dti-1423 76 12 although although SCONJ dti-1423 76 13 it it PRON dti-1423 76 14 has have AUX dti-1423 76 15 been be AUX dti-1423 76 16 associated associate VERB dti-1423 76 17 with with ADP dti-1423 76 18 increases increase NOUN dti-1423 76 19 in in ADP dti-1423 76 20 locomotor locomotor PROPN dti-1423 76 21 behaviors,65,89,90 behaviors,65,89,90 PROPN dti-1423 76 22 anxiogenic79 anxiogenic79 NOUN dti-1423 76 23 ( ( PUNCT dti-1423 76 24 but but CCONJ dti-1423 76 25 there there PRON dti-1423 76 26 is be VERB dti-1423 76 27 a a DET dti-1423 76 28 negative negative ADJ dti-1423 76 29 finding),65 finding),65 NOUN dti-1423 76 30 antiamnesic,80 antiamnesic,80 NOUN dti-1423 76 31 and and CCONJ dti-1423 76 32 antinociceptive antinociceptive ADJ dti-1423 76 33 effects75 effects75 NOUN dti-1423 76 34 in in ADP dti-1423 76 35 rodents rodent NOUN dti-1423 76 36 ( ( PUNCT dti-1423 76 37 table table NOUN dti-1423 76 38 1 1 NUM dti-1423 76 39 ) ) PUNCT dti-1423 76 40 . . PUNCT dti-1423 77 1 regarding regard VERB dti-1423 77 2 metoprine metoprine NOUN dti-1423 77 3 - - PUNCT dti-1423 77 4 induced induce VERB dti-1423 77 5 locomotor locomotor NOUN dti-1423 77 6 hyperactivity hyperactivity NOUN dti-1423 77 7 , , PUNCT dti-1423 77 8 a a DET dti-1423 77 9 dose dose NOUN dti-1423 77 10 – – PUNCT dti-1423 77 11 response response NOUN dti-1423 77 12 effect effect NOUN dti-1423 77 13 of of ADP dti-1423 77 14 metoprine metoprine NOUN dti-1423 77 15 on on ADP dti-1423 77 16 general general ADJ dti-1423 77 17 locomotion locomotion NOUN dti-1423 77 18 was be AUX dti-1423 77 19 biphasic biphasic ADJ dti-1423 77 20 with with ADP dti-1423 77 21 the the DET dti-1423 77 22 greatest great ADJ dti-1423 77 23 hyperactivity hyperactivity NOUN dti-1423 77 24 noted note VERB dti-1423 77 25 at at ADP dti-1423 77 26 a a DET dti-1423 77 27 dose dose NOUN dti-1423 77 28 of of ADP dti-1423 77 29 10 10 NUM dti-1423 77 30     SPACE dti-1423 77 31 mg mg PROPN dti-1423 77 32 / / SYM dti-1423 77 33 kg kg NOUN dti-1423 77 34 of of ADP dti-1423 77 35 metoprine.65 metoprine.65 NOUN dti-1423 77 36 the the DET dti-1423 77 37 biphasic biphasic ADJ dti-1423 77 38 reaction reaction NOUN dti-1423 77 39 to to PART dti-1423 77 40 metoprine metoprine PROPN dti-1423 77 41 dose dose NOUN dti-1423 77 42 appears appear VERB dti-1423 77 43 to to PART dti-1423 77 44 be be AUX dti-1423 77 45 mediated mediate VERB dti-1423 77 46 by by ADP dti-1423 77 47 brain brain NOUN dti-1423 77 48 histamine histamine NOUN dti-1423 77 49 - - PUNCT dti-1423 77 50 mediated mediate VERB dti-1423 77 51 effects effect NOUN dti-1423 77 52 , , PUNCT dti-1423 77 53 since since SCONJ dti-1423 77 54 histamine histamine NOUN dti-1423 77 55 itself itself PRON dti-1423 77 56 injected inject VERB dti-1423 77 57 into into ADP dti-1423 77 58 the the DET dti-1423 77 59 brain brain NOUN dti-1423 77 60 induces induce VERB dti-1423 77 61 biphasic biphasic ADJ dti-1423 77 62 locomotor locomotor NOUN dti-1423 77 63 alterations alteration NOUN dti-1423 77 64 as as SCONJ dti-1423 77 65 well.91,92 well.91,92 NOUN dti-1423 77 66 several several ADJ dti-1423 77 67 types type NOUN dti-1423 77 68 of of ADP dti-1423 77 69 seizures seizure NOUN dti-1423 77 70 are be AUX dti-1423 77 71 also also ADV dti-1423 77 72 inhibited inhibit VERB dti-1423 77 73 by by ADP dti-1423 77 74 metoprine metoprine NOUN dti-1423 77 75 ( ( PUNCT dti-1423 77 76 table table NOUN dti-1423 77 77 1).70,71,93,94 1).70,71,93,94 NUM dti-1423 77 78 whether whether SCONJ dti-1423 77 79 similar similar ADJ dti-1423 77 80 mechanisms mechanism NOUN dti-1423 77 81 underlie underlie VERB dti-1423 77 82 these these DET dti-1423 77 83 effects effect NOUN dti-1423 77 84 and and CCONJ dti-1423 77 85 effects effect NOUN dti-1423 77 86 on on ADP dti-1423 77 87 meth meth NOUN dti-1423 77 88 - - PUNCT dti-1423 77 89 induced induce VERB dti-1423 77 90 behavior behavior NOUN dti-1423 77 91 is be AUX dti-1423 77 92 uncertain uncertain ADJ dti-1423 77 93 . . PUNCT dti-1423 78 1 in in ADP dti-1423 78 2 any any DET dti-1423 78 3 case case NOUN dti-1423 78 4 , , PUNCT dti-1423 78 5 the the DET dti-1423 78 6 anticonvulsant anticonvulsant ADJ dti-1423 78 7 topiramate topiramate NOUN dti-1423 78 8 did do AUX dti-1423 78 9 not not PART dti-1423 78 10 affect affect VERB dti-1423 78 11 meth meth NOUN dti-1423 78 12 - - PUNCT dti-1423 78 13 induced induce VERB dti-1423 78 14 stereotypical stereotypical ADJ dti-1423 78 15 biting biting NOUN dti-1423 78 16 , , PUNCT dti-1423 78 17 suggesting suggest VERB dti-1423 78 18 that that SCONJ dti-1423 78 19 the the DET dti-1423 78 20 antagonism antagonism NOUN dti-1423 78 21 of of ADP dti-1423 78 22 meth meth NOUN dti-1423 78 23 - - PUNCT dti-1423 78 24 induced induce VERB dti-1423 78 25 effects effect NOUN dti-1423 78 26 by by ADP dti-1423 78 27 metoprine metoprine NOUN dti-1423 78 28 is be AUX dti-1423 78 29 not not PART dti-1423 78 30 something something PRON dti-1423 78 31 that that PRON dti-1423 78 32 is be AUX dti-1423 78 33 produced produce VERB dti-1423 78 34 by by ADP dti-1423 78 35 all all DET dti-1423 78 36 anticonvulsive anticonvulsive ADJ dti-1423 78 37 drugs.38 drugs.38 NOUN dti-1423 78 38 another another DET dti-1423 78 39 piece piece NOUN dti-1423 78 40 of of ADP dti-1423 78 41 evidence evidence NOUN dti-1423 78 42 consistent consistent ADJ dti-1423 78 43 with with ADP dti-1423 78 44 histaminergic histaminergic ADJ dti-1423 78 45 modulation modulation NOUN dti-1423 78 46 of of ADP dti-1423 78 47 systems system NOUN dti-1423 78 48 associated associate VERB dti-1423 78 49 with with ADP dti-1423 78 50 high high ADJ dti-1423 78 51 - - PUNCT dti-1423 78 52 dose dose NOUN dti-1423 78 53 meth meth NOUN dti-1423 78 54 effects effect NOUN dti-1423 78 55 comes come VERB dti-1423 78 56 from from ADP dti-1423 78 57 studies study NOUN dti-1423 78 58 of of ADP dti-1423 78 59 hdc hdc NOUN dti-1423 78 60 gene gene NOUN dti-1423 78 61 knockout knockout NOUN dti-1423 78 62 mice mouse NOUN dti-1423 78 63 , , PUNCT dti-1423 78 64 which which PRON dti-1423 78 65 demonstrate demonstrate VERB dti-1423 78 66 tic tic ADJ dti-1423 78 67 - - PUNCT dti-1423 78 68 like like ADJ dti-1423 78 69 stereotypical stereotypical ADJ dti-1423 78 70 movements movement NOUN dti-1423 78 71 , , PUNCT dti-1423 78 72 which which PRON dti-1423 78 73 can can AUX dti-1423 78 74 be be AUX dti-1423 78 75 ameliorated ameliorate VERB dti-1423 78 76 by by ADP dti-1423 78 77 histamine histamine NOUN dti-1423 78 78 repletion.95 repletion.95 NOUN dti-1423 78 79 this this PRON dti-1423 78 80 might might AUX dti-1423 78 81 table table VERB dti-1423 78 82 1 1 NUM dti-1423 78 83 . . PUNCT dti-1423 78 84 effects effect NOUN dti-1423 78 85 of of ADP dti-1423 78 86 hmt hmt NOUN dti-1423 78 87 inhibitors inhibitor NOUN dti-1423 78 88 on on ADP dti-1423 78 89 rodent rodent ADJ dti-1423 78 90 behaviors behavior NOUN dti-1423 78 91 . . PUNCT dti-1423 79 1 hmt hmt NOUN dti-1423 79 2 inhibitor inhibitor NOUN dti-1423 79 3 effect effect NOUN dti-1423 79 4 reference reference NOUN dti-1423 79 5 feeding feeding PROPN dti-1423 79 6 / / SYM dti-1423 79 7 drinking drinking NOUN dti-1423 79 8 metoprine metoprine NOUN dti-1423 79 9 decrease decrease NOUN dti-1423 79 10 in in ADP dti-1423 79 11 food food NOUN dti-1423 79 12 intake intake NOUN dti-1423 79 13 77 77 NUM dti-1423 79 14 metoprine metoprine NOUN dti-1423 79 15 increase increase NOUN dti-1423 79 16 in in ADP dti-1423 79 17 water water NOUN dti-1423 79 18 consumption consumption NOUN dti-1423 79 19 78 78 NUM dti-1423 79 20 mood mood NOUN dti-1423 79 21 metoprine metoprine NOUN dti-1423 79 22 anxiogenic anxiogenic NOUN dti-1423 79 23 - - PUNCT dti-1423 79 24 like like ADJ dti-1423 79 25 79 79 NUM dti-1423 79 26 memory memory NOUN dti-1423 79 27 process process NOUN dti-1423 79 28 metoprine metoprine NOUN dti-1423 79 29 antiamnesic antiamnesic ADJ dti-1423 79 30 80 80 NUM dti-1423 79 31 pain pain NOUN dti-1423 79 32 skf skf PROPN dti-1423 79 33 91488 91488 NUM dti-1423 79 34 antinociceptive antinociceptive VERB dti-1423 79 35 75 75 NUM dti-1423 79 36 bw bw PROPN dti-1423 79 37 301u 301u PROPN dti-1423 79 38 antinociceptive antinociceptive VERB dti-1423 79 39 75 75 NUM dti-1423 79 40 locomotor locomotor NOUN dti-1423 79 41 activity activity NOUN dti-1423 79 42 metoprine metoprine NOUN dti-1423 79 43 increase increase NOUN dti-1423 79 44 in in ADP dti-1423 79 45 locomotor locomotor ADJ dti-1423 79 46 activity activity NOUN dti-1423 79 47 89 89 NUM dti-1423 79 48 metoprine metoprine NOUN dti-1423 79 49 increase increase NOUN dti-1423 79 50 in in ADP dti-1423 79 51 number number NOUN dti-1423 79 52 of of ADP dti-1423 79 53 rearing rear VERB dti-1423 79 54 89 89 NUM dti-1423 79 55 metoprine metoprine NOUN dti-1423 79 56 increase increase NOUN dti-1423 79 57 in in ADP dti-1423 79 58 locomotor locomotor ADJ dti-1423 79 59 activity activity NOUN dti-1423 79 60 65 65 NUM dti-1423 79 61 metoprine metoprine NOUN dti-1423 79 62 increase increase NOUN dti-1423 79 63 in in ADP dti-1423 79 64 locomotor locomotor ADJ dti-1423 79 65 activity activity NOUN dti-1423 79 66 90 90 NUM dti-1423 79 67 seizures seizure NOUN dti-1423 79 68 metoprine metoprine NOUN dti-1423 79 69 inhibition inhibition NOUN dti-1423 79 70 of of ADP dti-1423 79 71 audiogenic audiogenic NOUN dti-1423 79 72 seizure seizure VERB dti-1423 79 73 93 93 NUM dti-1423 79 74 metoprine metoprine NOUN dti-1423 79 75 decrease decrease NOUN dti-1423 79 76 in in ADP dti-1423 79 77 duration duration NOUN dti-1423 79 78 of of ADP dti-1423 79 79 convulsions convulsion NOUN dti-1423 79 80 70 70 NUM dti-1423 79 81 metoprine metoprine NOUN dti-1423 79 82 inhibition inhibition NOUN dti-1423 79 83 of of ADP dti-1423 79 84 amygdaloid amygdaloid ADJ dti-1423 79 85 kindled kindle VERB dti-1423 79 86 seizure seizure VERB dti-1423 79 87 94 94 NUM dti-1423 79 88 metoprine metoprine NOUN dti-1423 79 89 delay delay NOUN dti-1423 79 90 in in ADP dti-1423 79 91 the the DET dti-1423 79 92 onset onset NOUN dti-1423 79 93 of of ADP dti-1423 79 94 seizure seizure NOUN dti-1423 79 95 episodes episode NOUN dti-1423 79 96 71 71 NUM dti-1423 79 97 meth meth NOUN dti-1423 79 98 - - PUNCT dti-1423 79 99 induced induce VERB dti-1423 79 100 behavior behavior NOUN dti-1423 79 101 metoprine metoprine NOUN dti-1423 79 102 decrease decrease NOUN dti-1423 79 103 in in ADP dti-1423 79 104 meth meth NOUN dti-1423 79 105 - - PUNCT dti-1423 79 106 induced induce VERB dti-1423 79 107 hyperlocomotion hyperlocomotion NOUN dti-1423 79 108 81 81 NUM dti-1423 79 109 metoprine metoprine NOUN dti-1423 79 110 decrease decrease NOUN dti-1423 79 111 in in ADP dti-1423 79 112 meth meth NOUN dti-1423 79 113 - - PUNCT dti-1423 79 114 induced induce VERB dti-1423 79 115 stereotypical stereotypical ADJ dti-1423 79 116 biting bite VERB dti-1423 79 117 65 65 NUM dti-1423 79 118 skf skf ADJ dti-1423 79 119 91488 91488 NUM dti-1423 79 120 decrease decrease NOUN dti-1423 79 121 in in ADP dti-1423 79 122 meth meth NOUN dti-1423 79 123 - - PUNCT dti-1423 79 124 induced induce VERB dti-1423 79 125 stereotypical stereotypical ADJ dti-1423 79 126 biting bite VERB dti-1423 79 127 65 65 NUM dti-1423 79 128 notes note NOUN dti-1423 79 129 : : PUNCT dti-1423 79 130 metoprine metoprine NOUN dti-1423 79 131 = = VERB dti-1423 79 132 2,4 2,4 NUM dti-1423 79 133 - - PUNCT dti-1423 79 134 diamino-5-(3′,4′-dichlorophenyl)-6 diamino-5-(3′,4′-dichlorophenyl)-6 ADP dti-1423 79 135 - - PUNCT dti-1423 79 136 methylpyrimidine methylpyrimidine NOUN dti-1423 79 137 , , PUNCT dti-1423 79 138 skf skf PROPN dti-1423 79 139 91488 91488 NUM dti-1423 79 140 = = SYM dti-1423 79 141 s-[4-(n s-[4-(n ADJ dti-1423 79 142 , , PUNCT dti-1423 79 143 n n CCONJ dti-1423 79 144 - - PUNCT dti-1423 79 145 dimethylamino)butyl]isothiourea dimethylamino)butyl]isothiourea NOUN dti-1423 79 146 , , PUNCT dti-1423 79 147 bw bw PROPN dti-1423 79 148 301u 301u PROPN dti-1423 79 149 = = SYM dti-1423 79 150 2,4 2,4 NUM dti-1423 79 151 diamino-6-(2,5 diamino-6-(2,5 NUM dti-1423 79 152 - - PUNCT dti-1423 79 153 dimethoxybenzyl)-5 dimethoxybenzyl)-5 PROPN dti-1423 79 154 - - PUNCT dti-1423 79 155 methylpyrido[2,3 methylpyrido[2,3 NOUN dti-1423 79 156 - - PUNCT dti-1423 79 157 d]pyrimidine d]pyrimidine NOUN dti-1423 79 158 . . PUNCT dti-1423 79 159 abbreviations abbreviation NOUN dti-1423 79 160 : : PUNCT dti-1423 79 161 hmt hmt NOUN dti-1423 79 162 , , PUNCT dti-1423 79 163 histamine histamine NOUN dti-1423 79 164 n n CCONJ dti-1423 79 165 - - PUNCT dti-1423 79 166 methyltransferase methyltransferase NOUN dti-1423 79 167 ; ; PUNCT dti-1423 79 168 meth meth NOUN dti-1423 79 169 , , PUNCT dti-1423 79 170 methamphetamine methamphetamine NOUN dti-1423 79 171 . . PUNCT dti-1423 79 172 http://www.la-press.com http://www.la-press.com X dti-1423 80 1 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1423 80 2 treatment treatment NOUN dti-1423 80 3 for for ADP dti-1423 80 4 methamphetamine methamphetamine NOUN dti-1423 80 5 overdose overdose ADP dti-1423 80 6 5drug 5drug NUM dti-1423 80 7 target target NOUN dti-1423 80 8 insights insight NOUN dti-1423 80 9 2016:10 2016:10 NUM dti-1423 80 10 suggest suggest VERB dti-1423 80 11 that that SCONJ dti-1423 80 12 modulation modulation NOUN dti-1423 80 13 of of ADP dti-1423 80 14 histaminergic histaminergic ADJ dti-1423 80 15 function function NOUN dti-1423 80 16 might might AUX dti-1423 80 17 be be AUX dti-1423 80 18 useful useful ADJ dti-1423 80 19 in in ADP dti-1423 80 20 other other ADJ dti-1423 80 21 types type NOUN dti-1423 80 22 of of ADP dti-1423 80 23 striatal striatal ADJ dti-1423 80 24 dysfunctions dysfunction NOUN dti-1423 80 25 associated associate VERB dti-1423 80 26 with with ADP dti-1423 80 27 abnormal abnormal ADJ dti-1423 80 28 movements movement NOUN dti-1423 80 29 , , PUNCT dti-1423 80 30 or or CCONJ dti-1423 80 31 repetitive repetitive ADJ dti-1423 80 32 behaviors behavior NOUN dti-1423 80 33 . . PUNCT dti-1423 81 1 with with ADP dti-1423 81 2 regard regard NOUN dti-1423 81 3 to to ADP dti-1423 81 4 the the DET dti-1423 81 5 high high ADV dti-1423 81 6 - - PUNCT dti-1423 81 7 dose dose NOUN dti-1423 81 8 meth meth NOUN dti-1423 81 9 effects effect NOUN dti-1423 81 10 associated associate VERB dti-1423 81 11 with with ADP dti-1423 81 12 sensitization sensitization NOUN dti-1423 81 13 or or CCONJ dti-1423 81 14 other other ADJ dti-1423 81 15 adverse adverse ADJ dti-1423 81 16 effects effect NOUN dti-1423 81 17 , , PUNCT dti-1423 81 18 it it PRON dti-1423 81 19 would would AUX dti-1423 81 20 appear appear VERB dti-1423 81 21 that that SCONJ dti-1423 81 22 metoprine metoprine NOUN dti-1423 81 23 may may AUX dti-1423 81 24 be be AUX dti-1423 81 25 beneficial beneficial ADJ dti-1423 81 26 based base VERB dti-1423 81 27 on on ADP dti-1423 81 28 the the DET dti-1423 81 29 model model NOUN dti-1423 81 30 discussed discuss VERB dti-1423 81 31 here here ADV dti-1423 81 32 . . PUNCT dti-1423 82 1 possible possible ADJ dti-1423 82 2 treatments treatment NOUN dti-1423 82 3 of of ADP dti-1423 82 4 metoprine metoprine NOUN dti-1423 82 5 with with ADP dti-1423 82 6 histamine histamine NOUN dti-1423 82 7 h3 h3 NOUN dti-1423 82 8 receptor receptor NOUN dti-1423 82 9 antagonists antagonist NOUN dti-1423 82 10 or or CCONJ dti-1423 82 11 with with ADP dti-1423 82 12 modafinil modafinil NOUN dti-1423 82 13 for for ADP dti-1423 82 14 meth meth NOUN dti-1423 82 15 overdose overdose NOUN dti-1423 82 16 should should AUX dti-1423 82 17 be be AUX dti-1423 82 18 evaluated evaluate VERB dti-1423 82 19 in in ADP dti-1423 82 20 the the DET dti-1423 82 21 future future ADJ dti-1423 82 22 studies study NOUN dti-1423 82 23 because because SCONJ dti-1423 82 24 histamine histamine NOUN dti-1423 82 25 h3 h3 NOUN dti-1423 82 26 receptor receptor NOUN dti-1423 82 27 antagonists antagonist NOUN dti-1423 82 28 and and CCONJ dti-1423 82 29 modafinil modafinil NOUN dti-1423 82 30 increase increase NOUN dti-1423 82 31 tissue tissue NOUN dti-1423 82 32 levels level NOUN dti-1423 82 33 of of ADP dti-1423 82 34 histamine histamine NOUN dti-1423 82 35 in in ADP dti-1423 82 36 the the DET dti-1423 82 37 hypothalamus.96,97 hypothalamus.96,97 NOUN dti-1423 82 38 it it PRON dti-1423 82 39 remains remain VERB dti-1423 82 40 to to PART dti-1423 82 41 be be AUX dti-1423 82 42 seen see VERB dti-1423 82 43 how how SCONJ dti-1423 82 44 metoprine metoprine NOUN dti-1423 82 45 will will AUX dti-1423 82 46 affect affect VERB dti-1423 82 47 other other ADJ dti-1423 82 48 meth meth NOUN dti-1423 82 49 - - PUNCT dti-1423 82 50 induced induce VERB dti-1423 82 51 behaviors behavior NOUN dti-1423 82 52 , , PUNCT dti-1423 82 53 specifically specifically ADV dti-1423 82 54 , , PUNCT dti-1423 82 55 including include VERB dti-1423 82 56 others other NOUN dti-1423 82 57 more more ADV dti-1423 82 58 specific specific ADJ dti-1423 82 59 to to ADP dti-1423 82 60 addiction addiction NOUN dti-1423 82 61 or or CCONJ dti-1423 82 62 meth meth NOUN dti-1423 82 63 overdose overdose ADV dti-1423 82 64 . . PUNCT dti-1423 83 1 in in ADP dti-1423 83 2 any any DET dti-1423 83 3 case case NOUN dti-1423 83 4 , , PUNCT dti-1423 83 5 the the DET dti-1423 83 6 present present ADJ dti-1423 83 7 data datum NOUN dti-1423 83 8 support support VERB dti-1423 83 9 the the DET dti-1423 83 10 proposal proposal NOUN dti-1423 83 11 that that PRON dti-1423 83 12 hmt hmt NOUN dti-1423 83 13 inhibitors inhibitor NOUN dti-1423 83 14 such such ADJ dti-1423 83 15 as as ADP dti-1423 83 16 metoprine metoprine NOUN dti-1423 83 17 are be AUX dti-1423 83 18 possible possible ADJ dti-1423 83 19 candidate candidate NOUN dti-1423 83 20 compounds compound NOUN dti-1423 83 21 for for ADP dti-1423 83 22 the the DET dti-1423 83 23 treatment treatment NOUN dti-1423 83 24 of of ADP dti-1423 83 25 meth meth NOUN dti-1423 83 26 - - PUNCT dti-1423 83 27 related relate VERB dti-1423 83 28 conditions condition NOUN dti-1423 83 29 , , PUNCT dti-1423 83 30 including include VERB dti-1423 83 31 meth meth NOUN dti-1423 83 32 - - PUNCT dti-1423 83 33 induced induce VERB dti-1423 83 34 psychosis psychosis NOUN dti-1423 83 35 and and CCONJ dti-1423 83 36 overdose overdose ADV dti-1423 83 37 . . PUNCT dti-1423 84 1 acknowledgments acknowledgment NOUN dti-1423 84 2 the the DET dti-1423 84 3 authors author NOUN dti-1423 84 4 are be AUX dti-1423 84 5 grateful grateful ADJ dti-1423 84 6 to to ADP dti-1423 84 7 dr dr PROPN dti-1423 84 8 . . PROPN dti-1423 84 9 tomohiro tomohiro PROPN dti-1423 84 10 tatsuta tatsuta PROPN dti-1423 84 11 of of ADP dti-1423 84 12 ibogawa ibogawa PROPN dti-1423 84 13 hospital hospital PROPN dti-1423 84 14 , , PUNCT dti-1423 84 15 hyogo hyogo PROPN dti-1423 84 16 , , PUNCT dti-1423 84 17 japan japan PROPN dti-1423 84 18 , , PUNCT dti-1423 84 19 for for ADP dti-1423 84 20 his his PRON dti-1423 84 21 remarkable remarkable ADJ dti-1423 84 22 contribution contribution NOUN dti-1423 84 23 to to ADP dti-1423 84 24 the the DET dti-1423 84 25 development development NOUN dti-1423 84 26 of of ADP dti-1423 84 27 a a DET dti-1423 84 28 method method NOUN dti-1423 84 29 to to PART dti-1423 84 30 evaluate evaluate VERB dti-1423 84 31 stereotypy stereotypy NOUN dti-1423 84 32 observed observe VERB dti-1423 84 33 under under ADP dti-1423 84 34 meth meth NOUN dti-1423 84 35 overdose overdose NOUN dti-1423 84 36 . . PUNCT dti-1423 85 1 metoprine metoprine NOUN dti-1423 85 2 was be AUX dti-1423 85 3 generously generously ADV dti-1423 85 4 donated donate VERB dti-1423 85 5 by by ADP dti-1423 85 6 glaxosmithkline glaxosmithkline PROPN dti-1423 85 7 ( ( PUNCT dti-1423 85 8 stevenage stevenage PROPN dti-1423 85 9 , , PUNCT dti-1423 85 10 uk uk PROPN dti-1423 85 11 ) ) PUNCT dti-1423 85 12 . . PUNCT dti-1423 86 1 author author NOUN dti-1423 86 2 contributions contribution NOUN dti-1423 86 3 conceived conceive VERB dti-1423 86 4 and and CCONJ dti-1423 86 5 designed design VERB dti-1423 86 6 the the DET dti-1423 86 7 experiments experiment NOUN dti-1423 86 8 : : PUNCT dti-1423 87 1 jk jk PROPN dti-1423 87 2 , , PUNCT dti-1423 87 3 nk nk PROPN dti-1423 87 4 , , PUNCT dti-1423 87 5 fsh fsh NOUN dti-1423 87 6 , , PUNCT dti-1423 87 7 and and CCONJ dti-1423 87 8 mt mt PROPN dti-1423 87 9 . . PROPN dti-1423 87 10 analyzed analyze VERB dti-1423 87 11 the the DET dti-1423 87 12 data datum NOUN dti-1423 87 13 : : PUNCT dti-1423 87 14 nk nk PROPN dti-1423 87 15 , , PUNCT dti-1423 87 16 jk jk PROPN dti-1423 87 17 , , PUNCT dti-1423 87 18 fsh fsh NOUN dti-1423 87 19 , , PUNCT dti-1423 87 20 and and CCONJ dti-1423 87 21 mt mt PROPN dti-1423 87 22 . . PROPN dti-1423 87 23 wrote write VERB dti-1423 87 24 the the DET dti-1423 87 25 first first ADJ dti-1423 87 26 draft draft NOUN dti-1423 87 27 of of ADP dti-1423 87 28 the the DET dti-1423 87 29 manuscript manuscript NOUN dti-1423 87 30 : : PUNCT dti-1423 87 31 nk nk PROPN dti-1423 87 32 , , PUNCT dti-1423 87 33 jk jk PROPN dti-1423 87 34 , , PUNCT dti-1423 87 35 fsh fsh PROPN dti-1423 87 36 , , PUNCT dti-1423 87 37 gru gru PROPN dti-1423 87 38 , , PUNCT dti-1423 87 39 and and CCONJ dti-1423 87 40 mt mt PROPN dti-1423 87 41 . . PROPN dti-1423 87 42 contributed contribute VERB dti-1423 87 43 to to ADP dti-1423 87 44 the the DET dti-1423 87 45 writing writing NOUN dti-1423 87 46 of of ADP dti-1423 87 47 the the DET dti-1423 87 48 manuscript manuscript NOUN dti-1423 87 49 : : PUNCT dti-1423 88 1 jk jk PROPN dti-1423 88 2 , , PUNCT dti-1423 88 3 nk nk PROPN dti-1423 88 4 , , PUNCT dti-1423 88 5 fsh fsh PROPN dti-1423 88 6 , , PUNCT dti-1423 88 7 gru gru PROPN dti-1423 88 8 , , PUNCT dti-1423 88 9 and and CCONJ dti-1423 88 10 mt mt PROPN dti-1423 88 11 . . PROPN dti-1423 88 12 agreed agree VERB dti-1423 88 13 with with ADP dti-1423 88 14 manuscript manuscript NOUN dti-1423 88 15 results result NOUN dti-1423 88 16 and and CCONJ dti-1423 88 17 conclusions conclusion NOUN dti-1423 88 18 : : PUNCT dti-1423 89 1 jk jk PROPN dti-1423 89 2 , , PUNCT dti-1423 89 3 nk nk PROPN dti-1423 89 4 , , PUNCT dti-1423 89 5 fsh fsh PROPN dti-1423 89 6 , , PUNCT dti-1423 89 7 gru gru PROPN dti-1423 89 8 , , PUNCT dti-1423 89 9 and and CCONJ dti-1423 89 10 mt mt PROPN dti-1423 89 11 . . PROPN dti-1423 89 12 jointly jointly ADV dti-1423 89 13 developed develop VERB dti-1423 89 14 the the DET dti-1423 89 15 structure structure NOUN dti-1423 89 16 and and CCONJ dti-1423 89 17 arguments argument NOUN dti-1423 89 18 for for ADP dti-1423 89 19 the the DET dti-1423 89 20 paper paper NOUN dti-1423 89 21 : : PUNCT dti-1423 89 22 fsh fsh PROPN dti-1423 89 23 and and CCONJ dti-1423 89 24 gru gru PROPN dti-1423 89 25 . . PROPN dti-1423 89 26 made make VERB dti-1423 89 27 critical critical ADJ dti-1423 89 28 revisions revision NOUN dti-1423 89 29 and and CCONJ dti-1423 89 30 approved approve VERB dti-1423 89 31 the the DET dti-1423 89 32 final final ADJ dti-1423 89 33 version version NOUN dti-1423 89 34 : : PUNCT dti-1423 89 35 jk jk PROPN dti-1423 89 36 , , PUNCT dti-1423 89 37 nk nk PROPN dti-1423 89 38 , , PUNCT dti-1423 89 39 fsh fsh PROPN dti-1423 89 40 , , PUNCT dti-1423 89 41 gru gru PROPN dti-1423 89 42 , , PUNCT dti-1423 89 43 and and CCONJ dti-1423 89 44 mt mt PROPN dti-1423 89 45 . . PUNCT dti-1423 90 1 all all DET dti-1423 90 2 the the DET dti-1423 90 3 authors author NOUN dti-1423 90 4 reviewed review VERB dti-1423 90 5 and and CCONJ dti-1423 90 6 approved approve VERB dti-1423 90 7 the the DET dti-1423 90 8 final final ADJ dti-1423 90 9 manuscript manuscript NOUN dti-1423 90 10 . . PUNCT dti-1423 91 1 references reference NOUN dti-1423 91 2 1 1 NUM dti-1423 91 3 . . PUNCT dti-1423 91 4 sanchez sanchez PROPN dti-1423 91 5 - - PUNCT dti-1423 91 6 ramos ramos PROPN dti-1423 91 7 j. j. PROPN dti-1423 91 8 neurologic neurologic ADJ dti-1423 91 9 complications complication NOUN dti-1423 91 10 of of ADP dti-1423 91 11 psychomotor psychomotor NOUN dti-1423 91 12 stimulant stimulant ADJ dti-1423 91 13 abuse abuse NOUN dti-1423 91 14 . . PUNCT dti-1423 92 1 int int PROPN dti-1423 92 2 rev rev PROPN dti-1423 92 3 neurobiol neurobiol PROPN dti-1423 92 4 . . PUNCT dti-1423 93 1 2015;120:131–160 2015;120:131–160 NUM dti-1423 93 2 . . NOUN dti-1423 93 3 2 2 NUM dti-1423 93 4 . . X dti-1423 93 5 ujike ujike PROPN dti-1423 93 6 h h NOUN dti-1423 93 7 , , PUNCT dti-1423 93 8 sato sato NOUN dti-1423 93 9 m. m. NOUN dti-1423 93 10 clinical clinical ADJ dti-1423 93 11 features feature NOUN dti-1423 93 12 of of ADP dti-1423 93 13 sensitization sensitization NOUN dti-1423 93 14 to to PART dti-1423 93 15 methamphetamine methamphetamine NOUN dti-1423 93 16 observed observe VERB dti-1423 93 17 in in ADP dti-1423 93 18 patients patient NOUN dti-1423 93 19 with with ADP dti-1423 93 20 methamphetamine methamphetamine NOUN dti-1423 93 21 dependence dependence NOUN dti-1423 93 22 and and CCONJ dti-1423 93 23 psychosis psychosis NOUN dti-1423 93 24 . . PUNCT dti-1423 94 1 ann ann PROPN dti-1423 94 2 n n PROPN dti-1423 94 3 y y PROPN dti-1423 94 4 acad acad PROPN dti-1423 94 5 sci sci PROPN dti-1423 94 6 . . PROPN dti-1423 94 7 2004;1025:279–287 2004;1025:279–287 PROPN dti-1423 94 8 . . PUNCT dti-1423 95 1 3 3 X dti-1423 95 2 . . X dti-1423 95 3 greberman greberman PROPN dti-1423 95 4 sb sb PROPN dti-1423 95 5 , , PUNCT dti-1423 95 6 wada wada PROPN dti-1423 95 7 k. k. PROPN dti-1423 96 1 social social PROPN dti-1423 96 2 and and CCONJ dti-1423 96 3 legal legal ADJ dti-1423 96 4 factors factor NOUN dti-1423 96 5 related relate VERB dti-1423 96 6 to to ADP dti-1423 96 7 drug drug NOUN dti-1423 96 8 abuse abuse NOUN dti-1423 96 9 in in ADP dti-1423 96 10 the the DET dti-1423 96 11 united united PROPN dti-1423 96 12 states states PROPN dti-1423 96 13 and and CCONJ dti-1423 96 14 japan japan PROPN dti-1423 96 15 . . PUNCT dti-1423 97 1 public public ADJ dti-1423 97 2 health health PROPN dti-1423 97 3 rep rep PROPN dti-1423 97 4 . . PROPN dti-1423 97 5 1994;109(6):731–737 1994;109(6):731–737 NUM dti-1423 97 6 . . PUNCT dti-1423 98 1 4 4 X dti-1423 98 2 . . X dti-1423 98 3 national national PROPN dti-1423 98 4 institute institute PROPN dti-1423 98 5 on on ADP dti-1423 98 6 drug drug NOUN dti-1423 98 7 abuse abuse NOUN dti-1423 98 8 . . PUNCT dti-1423 99 1 nida nida PROPN dti-1423 99 2 drugfacts drugfact VERB dti-1423 99 3 : : PUNCT dti-1423 99 4 methamphetamine methamphetamine NOUN dti-1423 99 5 ; ; PUNCT dti-1423 99 6 2014 2014 NUM dti-1423 99 7 . . PUNCT dti-1423 100 1 available available ADJ dti-1423 100 2 at at ADP dti-1423 100 3 : : PUNCT dti-1423 100 4 http://www.drugabuse.gov/publications/drugfacts/methamphetamine http://www.drugabuse.gov/publications/drugfacts/methamphetamine ADJ dti-1423 100 5 . . PUNCT dti-1423 101 1 accessed access VERB dti-1423 101 2 september september PROPN dti-1423 101 3 16 16 NUM dti-1423 101 4 , , PUNCT dti-1423 101 5 2015 2015 NUM dti-1423 101 6 . . PUNCT dti-1423 102 1 5 5 X dti-1423 102 2 . . X dti-1423 102 3 sato sato NOUN dti-1423 102 4 m. m. NOUN dti-1423 102 5 a a DET dti-1423 102 6 lasting last VERB dti-1423 102 7 vulnerability vulnerability NOUN dti-1423 102 8 to to ADP dti-1423 102 9 psychosis psychosis NOUN dti-1423 102 10 in in ADP dti-1423 102 11 patients patient NOUN dti-1423 102 12 with with ADP dti-1423 102 13 previous previous ADJ dti-1423 102 14 methamphetamine methamphetamine NOUN dti-1423 102 15 psychosis psychosis NOUN dti-1423 102 16 . . PUNCT dti-1423 103 1 ann ann PROPN dti-1423 103 2 n n PROPN dti-1423 103 3 y y PROPN dti-1423 103 4 acad acad PROPN dti-1423 103 5 sci sci PROPN dti-1423 103 6 . . PROPN dti-1423 103 7 1992;654:160–170 1992;654:160–170 NUM dti-1423 103 8 . . PUNCT dti-1423 104 1 6 6 NUM dti-1423 104 2 . . X dti-1423 104 3 cruickshank cruickshank PROPN dti-1423 104 4 cc cc PROPN dti-1423 104 5 , , PUNCT dti-1423 104 6 dyer dyer PROPN dti-1423 104 7 kr kr PROPN dti-1423 104 8 . . PUNCT dti-1423 105 1 a a DET dti-1423 105 2 review review NOUN dti-1423 105 3 of of ADP dti-1423 105 4 the the DET dti-1423 105 5 clinical clinical ADJ dti-1423 105 6 pharmacology pharmacology NOUN dti-1423 105 7 of of ADP dti-1423 105 8 methamphetamine methamphetamine NOUN dti-1423 105 9 . . PUNCT dti-1423 106 1 addiction addiction NOUN dti-1423 106 2 . . PUNCT dti-1423 107 1 2009;104(7):1085–1099 2009;104(7):1085–1099 NUM dti-1423 107 2 . . X dti-1423 107 3 7 7 X dti-1423 107 4 . . NUM dti-1423 107 5 brackins brackin VERB dti-1423 107 6 t t PROPN dti-1423 107 7 , , PUNCT dti-1423 107 8 brahm brahm PROPN dti-1423 107 9 nc nc PROPN dti-1423 107 10 , , PUNCT dti-1423 107 11 kissack kissack PROPN dti-1423 107 12 jc jc PROPN dti-1423 107 13 . . PROPN dti-1423 108 1 treatments treatment NOUN dti-1423 108 2 for for ADP dti-1423 108 3 methamphetamine methamphetamine NOUN dti-1423 108 4 abuse abuse NOUN dti-1423 108 5 : : PUNCT dti-1423 108 6 a a DET dti-1423 108 7     SPACE dti-1423 108 8 literature literature NOUN dti-1423 108 9 review review NOUN dti-1423 108 10 for for ADP dti-1423 108 11 the the DET dti-1423 108 12 clinician clinician NOUN dti-1423 108 13 . . PUNCT dti-1423 109 1 j j PROPN dti-1423 109 2 pharm pharm PROPN dti-1423 109 3 pract pract PROPN dti-1423 109 4 . . PUNCT dti-1423 110 1 2011;24(6):541–550 2011;24(6):541–550 NUM dti-1423 110 2 . . NOUN dti-1423 110 3 8 8 NUM dti-1423 110 4 . . PUNCT dti-1423 111 1 murray murray PROPN dti-1423 111 2 jb jb PROPN dti-1423 111 3 . . PUNCT dti-1423 112 1 psychophysiological psychophysiological ADJ dti-1423 112 2 aspects aspect NOUN dti-1423 112 3 of of ADP dti-1423 112 4 amphetamine amphetamine NOUN dti-1423 112 5 - - PUNCT dti-1423 112 6 methamphetamine methamphetamine NOUN dti-1423 112 7 abuse abuse NOUN dti-1423 112 8 . . PUNCT dti-1423 113 1 j j PROPN dti-1423 113 2 psychol psychol PROPN dti-1423 113 3 . . PUNCT dti-1423 114 1 1998;132(2):227–237 1998;132(2):227–237 NUM dti-1423 114 2 . . NOUN dti-1423 114 3 9 9 NUM dti-1423 114 4 . . X dti-1423 114 5 karila karila PROPN dti-1423 114 6 l l PROPN dti-1423 114 7 , , PUNCT dti-1423 114 8 weinstein weinstein PROPN dti-1423 114 9 a a PROPN dti-1423 114 10 , , PUNCT dti-1423 114 11 aubin aubin PROPN dti-1423 114 12 hj hj PROPN dti-1423 114 13 , , PUNCT dti-1423 114 14 benyamina benyamina PROPN dti-1423 114 15 a a PRON dti-1423 114 16 , , PUNCT dti-1423 114 17 reynaud reynaud PROPN dti-1423 114 18 m m PROPN dti-1423 114 19 , , PUNCT dti-1423 114 20 batki batki NOUN dti-1423 114 21 sl sl VERB dti-1423 114 22 . . PUNCT dti-1423 114 23 pharmacological pharmacological ADJ dti-1423 114 24 approaches approach NOUN dti-1423 114 25 to to ADP dti-1423 114 26 methamphetamine methamphetamine NOUN dti-1423 114 27 dependence dependence NOUN dti-1423 114 28 : : PUNCT dti-1423 114 29 a a DET dti-1423 114 30 focused focused ADJ dti-1423 114 31 review review NOUN dti-1423 114 32 . . PUNCT dti-1423 115 1 br br PUNCT dti-1423 116 1 j j PROPN dti-1423 116 2     SPACE dti-1423 116 3 clin clin PROPN dti-1423 116 4 pharmacol pharmacol PROPN dti-1423 116 5 . . PUNCT dti-1423 117 1 2010;69(6):578–592 2010;69(6):578–592 NUM dti-1423 117 2 . . PROPN dti-1423 117 3 10 10 NUM dti-1423 117 4 . . PUNCT dti-1423 118 1 cretzmeyer cretzmeyer PROPN dti-1423 118 2 m m PROPN dti-1423 118 3 , , PUNCT dti-1423 118 4 sarrazin sarrazin PROPN dti-1423 118 5 mv mv PROPN dti-1423 118 6 , , PUNCT dti-1423 118 7 huber huber PROPN dti-1423 118 8 dl dl PROPN dti-1423 118 9 , , PUNCT dti-1423 118 10 block block PROPN dti-1423 118 11 ri ri PROPN dti-1423 118 12 , , PUNCT dti-1423 118 13 hall hall PROPN dti-1423 118 14 ja ja PROPN dti-1423 118 15 . . PUNCT dti-1423 119 1 treatment treatment NOUN dti-1423 119 2 of of ADP dti-1423 119 3 methamphetamine methamphetamine NOUN dti-1423 119 4 abuse abuse NOUN dti-1423 119 5 : : PUNCT dti-1423 119 6 research research NOUN dti-1423 119 7 findings finding NOUN dti-1423 119 8 and and CCONJ dti-1423 119 9 clinical clinical ADJ dti-1423 119 10 directions direction NOUN dti-1423 119 11 . . PUNCT dti-1423 120 1 j j PROPN dti-1423 120 2 subst subst NOUN dti-1423 120 3 abuse abuse NOUN dti-1423 120 4 treat treat NOUN dti-1423 120 5 . . PUNCT dti-1423 121 1 2003;24(3):267–277 2003;24(3):267–277 X dti-1423 121 2 . . PUNCT dti-1423 122 1 11 11 NUM dti-1423 122 2 . . PUNCT dti-1423 123 1 seiden seiden PROPN dti-1423 123 2 ls ls PROPN dti-1423 123 3 , , PUNCT dti-1423 123 4 sabol sabol PROPN dti-1423 123 5 ke ke PROPN dti-1423 123 6 , , PUNCT dti-1423 123 7 ricaurte ricaurte PROPN dti-1423 123 8 ga ga PROPN dti-1423 123 9 . . PROPN dti-1423 123 10 amphetamine amphetamine PROPN dti-1423 123 11 : : PUNCT dti-1423 123 12 effects effect NOUN dti-1423 123 13 on on ADP dti-1423 123 14 catecholamine catecholamine NOUN dti-1423 123 15 systems system NOUN dti-1423 123 16 and and CCONJ dti-1423 123 17 behavior behavior NOUN dti-1423 123 18 . . PUNCT dti-1423 124 1 annu annu PROPN dti-1423 124 2 rev rev VERB dti-1423 124 3 pharmacol pharmacol PROPN dti-1423 124 4 toxicol toxicol PROPN dti-1423 124 5 . . PUNCT dti-1423 125 1 1993;33:639–677 1993;33:639–677 NUM dti-1423 125 2 . . PUNCT dti-1423 126 1 12 12 NUM dti-1423 126 2 . . PUNCT dti-1423 127 1 sulzer sulzer PROPN dti-1423 127 2 d. d. PROPN dti-1423 127 3 how how SCONJ dti-1423 127 4 addictive addictive ADJ dti-1423 127 5 drugs drug NOUN dti-1423 127 6 disrupt disrupt VERB dti-1423 127 7 presynaptic presynaptic ADJ dti-1423 127 8 dopamine dopamine NOUN dti-1423 127 9 neurotransmission neurotransmission NOUN dti-1423 127 10 . . PUNCT dti-1423 128 1 neuron neuron PROPN dti-1423 128 2 . . PUNCT dti-1423 129 1 2011;69(4):628–649 2011;69(4):628–649 X dti-1423 129 2 . . NOUN dti-1423 129 3 13 13 NUM dti-1423 129 4 . . PUNCT dti-1423 130 1 goodwin goodwin PROPN dti-1423 130 2 js js PROPN dti-1423 130 3 , , PUNCT dti-1423 130 4 larson larson PROPN dti-1423 130 5 ga ga PROPN dti-1423 130 6 , , PUNCT dti-1423 130 7 swant swant PROPN dti-1423 130 8 j j PROPN dti-1423 130 9 , , PUNCT dti-1423 130 10 et et PROPN dti-1423 130 11 al al PROPN dti-1423 130 12 . . PROPN dti-1423 130 13 amphetamine amphetamine PROPN dti-1423 130 14 and and CCONJ dti-1423 130 15 methamphetamine methamphetamine NOUN dti-1423 130 16 differentially differentially ADV dti-1423 130 17 affect affect VERB dti-1423 130 18 dopamine dopamine NOUN dti-1423 130 19 transporters transporter NOUN dti-1423 130 20 in in ADP dti-1423 130 21 vitro vitro X dti-1423 130 22 and and CCONJ dti-1423 130 23 in in ADP dti-1423 130 24 vivo vivo NOUN dti-1423 130 25 . . PUNCT dti-1423 131 1 j j PROPN dti-1423 131 2 biol biol PROPN dti-1423 131 3 chem chem NOUN dti-1423 131 4 . . PUNCT dti-1423 132 1 2009 2009 NUM dti-1423 132 2 ; ; PUNCT dti-1423 132 3 284(5):2978–2989 284(5):2978–2989 NUM dti-1423 132 4 . . PUNCT dti-1423 133 1 14 14 NUM dti-1423 133 2 . . PUNCT dti-1423 134 1 eshleman eshleman PROPN dti-1423 134 2 aj aj PROPN dti-1423 134 3 , , PUNCT dti-1423 134 4 henningsen henningsen PROPN dti-1423 134 5 ra ra PROPN dti-1423 134 6 , , PUNCT dti-1423 134 7 neve neve PROPN dti-1423 134 8 ka ka PROPN dti-1423 134 9 , , PUNCT dti-1423 134 10 janowsky janowsky ADJ dti-1423 134 11 a. a. NOUN dti-1423 134 12 release release NOUN dti-1423 134 13 of of ADP dti-1423 134 14 dopamine dopamine NOUN dti-1423 134 15 via via ADP dti-1423 134 16 the the DET dti-1423 134 17 human human ADJ dti-1423 134 18 transporter transporter NOUN dti-1423 134 19 . . PUNCT dti-1423 135 1 mol mol ADP dti-1423 135 2 pharmacol pharmacol PROPN dti-1423 135 3 . . PUNCT dti-1423 136 1 1994;45(2):312–316 1994;45(2):312–316 NUM dti-1423 136 2 . . NOUN dti-1423 136 3 15 15 NUM dti-1423 136 4 . . PUNCT dti-1423 137 1 shoblock shoblock PROPN dti-1423 137 2 jr jr PROPN dti-1423 137 3 , , PUNCT dti-1423 137 4 sullivan sullivan PROPN dti-1423 137 5 eb eb PROPN dti-1423 137 6 , , PUNCT dti-1423 137 7 maisonneuve maisonneuve VERB dti-1423 137 8 i i PRON dti-1423 137 9 m m PROPN dti-1423 137 10 , , PUNCT dti-1423 137 11 glick glick PROPN dti-1423 137 12 sd sd PROPN dti-1423 137 13 . . PUNCT dti-1423 137 14 neurochemical neurochemical ADJ dti-1423 137 15 and and CCONJ dti-1423 137 16 behavioral behavioral ADJ dti-1423 137 17 differences difference NOUN dti-1423 137 18 between between ADP dti-1423 137 19 d d NOUN dti-1423 137 20 - - PUNCT dti-1423 137 21 methamphetamine methamphetamine NOUN dti-1423 137 22 and and CCONJ dti-1423 137 23 d d NOUN dti-1423 137 24 - - PUNCT dti-1423 137 25 amphetamine amphetamine VERB dti-1423 137 26 in in ADP dti-1423 137 27 rats rat NOUN dti-1423 137 28 . . PUNCT dti-1423 138 1 psychopharmacology psychopharmacology NOUN dti-1423 138 2 . . PUNCT dti-1423 139 1 2003;165(4):359–369 2003;165(4):359–369 NUM dti-1423 139 2 . . PROPN dti-1423 139 3 16 16 NUM dti-1423 139 4 . . PUNCT dti-1423 140 1 nishikawa nishikawa PROPN dti-1423 140 2 t t PROPN dti-1423 140 3 , , PUNCT dti-1423 140 4 mataga mataga NOUN dti-1423 140 5 n n CCONJ dti-1423 140 6 , , PUNCT dti-1423 140 7 takashima takashima PROPN dti-1423 140 8 m m PROPN dti-1423 140 9 , , PUNCT dti-1423 140 10 toru toru PROPN dti-1423 140 11 m. m. NOUN dti-1423 140 12 behavioral behavioral ADJ dti-1423 140 13 sensitization sensitization NOUN dti-1423 140 14 and and CCONJ dti-1423 140 15 relative relative ADJ dti-1423 140 16 hyperresponsiveness hyperresponsiveness NOUN dti-1423 140 17 of of ADP dti-1423 140 18 striatal striatal ADJ dti-1423 140 19 and and CCONJ dti-1423 140 20 limbic limbic ADJ dti-1423 140 21 dopaminergic dopaminergic ADJ dti-1423 140 22 neurons neuron NOUN dti-1423 140 23 after after ADP dti-1423 140 24 repeated repeat VERB dti-1423 140 25 methamphetamine methamphetamine NOUN dti-1423 140 26 treatment treatment NOUN dti-1423 140 27 . . PUNCT dti-1423 141 1 eur eur PROPN dti-1423 141 2 j j PROPN dti-1423 141 3 pharmacol pharmacol PROPN dti-1423 141 4 . . PUNCT dti-1423 142 1 1983;88(2–3):195–203 1983;88(2–3):195–203 NUM dti-1423 142 2 . . PUNCT dti-1423 143 1 17 17 NUM dti-1423 143 2 . . PUNCT dti-1423 143 3 grant grant PROPN dti-1423 143 4 km km PROPN dti-1423 143 5 , , PUNCT dti-1423 143 6 levan levan PROPN dti-1423 143 7 td td PROPN dti-1423 143 8 , , PUNCT dti-1423 143 9 wells wells PROPN dti-1423 143 10 sm sm PROPN dti-1423 143 11 , , PUNCT dti-1423 143 12 et et PROPN dti-1423 143 13 al al PROPN dti-1423 143 14 . . PROPN dti-1423 143 15 methamphetamine methamphetamine NOUN dti-1423 143 16 - - PUNCT dti-1423 143 17 associated associate VERB dti-1423 143 18 psychosis psychosis NOUN dti-1423 143 19 . . PUNCT dti-1423 144 1 j j PROPN dti-1423 144 2 neuroimmune neuroimmune PROPN dti-1423 144 3 pharmacol pharmacol PROPN dti-1423 144 4 . . PUNCT dti-1423 145 1 2012;7(1):113–139 2012;7(1):113–139 NUM dti-1423 145 2 . . PROPN dti-1423 145 3 18 18 NUM dti-1423 145 4 . . PUNCT dti-1423 145 5 verachai verachai PROPN dti-1423 145 6 v v PROPN dti-1423 145 7 , , PUNCT dti-1423 145 8 rukngan rukngan ADJ dti-1423 145 9 w w PROPN dti-1423 145 10 , , PUNCT dti-1423 145 11 chawanakrasaesin chawanakrasaesin PROPN dti-1423 145 12 k k PROPN dti-1423 145 13 , , PUNCT dti-1423 145 14 et et PROPN dti-1423 145 15 al al PROPN dti-1423 145 16 . . PUNCT dti-1423 146 1 treatment treatment NOUN dti-1423 146 2 of of ADP dti-1423 146 3 methamphetamine methamphetamine NOUN dti-1423 146 4 - - PUNCT dti-1423 146 5 induced induce VERB dti-1423 146 6 psychosis psychosis NOUN dti-1423 146 7 : : PUNCT dti-1423 146 8 a a DET dti-1423 146 9 double double ADJ dti-1423 146 10 - - PUNCT dti-1423 146 11 blind blind ADJ dti-1423 146 12 randomized randomize VERB dti-1423 146 13 controlled control VERB dti-1423 146 14 trial trial NOUN dti-1423 146 15 comparing compare VERB dti-1423 146 16 haloperidol haloperidol NOUN dti-1423 146 17 and and CCONJ dti-1423 146 18 quetiapine quetiapine NOUN dti-1423 146 19 . . PUNCT dti-1423 147 1 psychopharmacology psychopharmacology NOUN dti-1423 147 2 . . PUNCT dti-1423 148 1 2014;231(16):3099–3108 2014;231(16):3099–3108 NUM dti-1423 148 2 . . PUNCT dti-1423 149 1 19 19 NUM dti-1423 149 2 . . PUNCT dti-1423 150 1 gao gao PROPN dti-1423 150 2 k k PROPN dti-1423 150 3 , , PUNCT dti-1423 150 4 kemp kemp PROPN dti-1423 150 5 de de PROPN dti-1423 150 6 , , PUNCT dti-1423 150 7 ganocy ganocy PROPN dti-1423 150 8 sj sj PROPN dti-1423 150 9 , , PUNCT dti-1423 150 10 gajwani gajwani NOUN dti-1423 150 11 p p NOUN dti-1423 150 12 , , PUNCT dti-1423 150 13 xia xia PROPN dti-1423 150 14 g g PROPN dti-1423 150 15 , , PUNCT dti-1423 150 16 calabrese calabrese PROPN dti-1423 150 17 jr jr PROPN dti-1423 150 18 . . PROPN dti-1423 150 19 antipsychoticinduced antipsychoticinduce VERB dti-1423 150 20 extrapyramidal extrapyramidal ADJ dti-1423 150 21 side side NOUN dti-1423 150 22 effects effect NOUN dti-1423 150 23 in in ADP dti-1423 150 24 bipolar bipolar ADJ dti-1423 150 25 disorder disorder NOUN dti-1423 150 26 and and CCONJ dti-1423 150 27 schizophrenia schizophrenia NOUN dti-1423 150 28 : : PUNCT dti-1423 150 29 a a DET dti-1423 150 30 systematic systematic ADJ dti-1423 150 31 review review NOUN dti-1423 150 32 . . PUNCT dti-1423 151 1 j j PROPN dti-1423 151 2 clin clin PROPN dti-1423 151 3 psychopharmacol psychopharmacol PROPN dti-1423 151 4 . . PUNCT dti-1423 152 1 2008;28(2):203–209 2008;28(2):203–209 NUM dti-1423 152 2 . . PUNCT dti-1423 153 1 20 20 NUM dti-1423 153 2 . . PUNCT dti-1423 154 1 haddad haddad PROPN dti-1423 154 2 pm pm PROPN dti-1423 154 3 , , PUNCT dti-1423 154 4 das das PROPN dti-1423 154 5 a a PRON dti-1423 154 6 , , PUNCT dti-1423 154 7 keyhani keyhani PROPN dti-1423 154 8 s. s. PROPN dti-1423 154 9 antipsychotic antipsychotic ADJ dti-1423 154 10 drugs drug NOUN dti-1423 154 11 and and CCONJ dti-1423 154 12 extrapyramidal extrapyramidal ADJ dti-1423 154 13 side side NOUN dti-1423 154 14 effects effect NOUN dti-1423 154 15 in in ADP dti-1423 154 16 first first ADJ dti-1423 154 17 episode episode NOUN dti-1423 154 18 psychosis psychosis NOUN dti-1423 154 19 : : PUNCT dti-1423 154 20 a a DET dti-1423 154 21 systematic systematic ADJ dti-1423 154 22 review review NOUN dti-1423 154 23 of of ADP dti-1423 154 24 head head NOUN dti-1423 154 25 - - PUNCT dti-1423 154 26 head head NOUN dti-1423 154 27 comparisons comparison NOUN dti-1423 154 28 . . PUNCT dti-1423 155 1 j j PROPN dti-1423 155 2 psychopharmacol psychopharmacol PROPN dti-1423 155 3 . . PUNCT dti-1423 155 4 2012;26(5 2012;26(5 NUM dti-1423 155 5 suppl):15–26 suppl):15–26 NUM dti-1423 155 6 . . PUNCT dti-1423 156 1 21 21 NUM dti-1423 156 2 . . PUNCT dti-1423 157 1 grant grant PROPN dti-1423 157 2 je je PROPN dti-1423 157 3 , , PUNCT dti-1423 157 4 odlaug odlaug PROPN dti-1423 157 5 bl bl PROPN dti-1423 157 6 , , PUNCT dti-1423 157 7 kim kim PROPN dti-1423 157 8 sw sw PROPN dti-1423 157 9 . . PUNCT dti-1423 158 1 a a DET dti-1423 158 2 double double ADJ dti-1423 158 3 - - PUNCT dti-1423 158 4 blind blind ADJ dti-1423 158 5 , , PUNCT dti-1423 158 6 placebo placebo NOUN dti-1423 158 7 - - PUNCT dti-1423 158 8 controlled control VERB dti-1423 158 9 study study NOUN dti-1423 158 10 of of ADP dti-1423 158 11 n n CCONJ dti-1423 158 12 - - PUNCT dti-1423 158 13 acetyl acetyl NOUN dti-1423 158 14 cysteine cysteine NOUN dti-1423 158 15 plus plus CCONJ dti-1423 158 16 naltrexone naltrexone NOUN dti-1423 158 17 for for ADP dti-1423 158 18 methamphetamine methamphetamine NOUN dti-1423 158 19 dependence dependence NOUN dti-1423 158 20 . . PUNCT dti-1423 159 1 eur eur PROPN dti-1423 159 2 neuropsychopharmacol neuropsychopharmacol PROPN dti-1423 159 3 . . PUNCT dti-1423 160 1 2010;20(11):823–828 2010;20(11):823–828 NUM dti-1423 160 2 . . PUNCT dti-1423 161 1 22 22 NUM dti-1423 161 2 . . PUNCT dti-1423 162 1 whitfield whitfield PROPN dti-1423 162 2 tw tw PROPN dti-1423 162 3 jr jr PROPN dti-1423 162 4 , , PUNCT dti-1423 162 5 schlosburg schlosburg PROPN dti-1423 162 6 je je PROPN dti-1423 162 7 , , PUNCT dti-1423 162 8 wee wee PROPN dti-1423 162 9 s s PROPN dti-1423 162 10 , , PUNCT dti-1423 162 11 et et PROPN dti-1423 162 12 al al PROPN dti-1423 162 13 . . PROPN dti-1423 162 14 kappa kappa PROPN dti-1423 162 15 opioid opioid ADJ dti-1423 162 16 receptors receptor NOUN dti-1423 162 17 in in ADP dti-1423 162 18 the the DET dti-1423 162 19 nucleus nucleus NOUN dti-1423 162 20 accumbens accumben NOUN dti-1423 162 21 shell shell VERB dti-1423 162 22 mediate mediate ADJ dti-1423 162 23 escalation escalation NOUN dti-1423 162 24 of of ADP dti-1423 162 25 methamphetamine methamphetamine NOUN dti-1423 162 26 intake intake NOUN dti-1423 162 27 . . PUNCT dti-1423 163 1 j j PROPN dti-1423 163 2     SPACE dti-1423 163 3 neurosci neurosci PROPN dti-1423 163 4 . . PUNCT dti-1423 164 1 2015;35(10):4296–4305 2015;35(10):4296–4305 X dti-1423 164 2 . . PUNCT dti-1423 165 1 23 23 NUM dti-1423 165 2 . . PUNCT dti-1423 166 1 thorn thorn NOUN dti-1423 166 2 da da PROPN dti-1423 166 3 , , PUNCT dti-1423 166 4 winter winter PROPN dti-1423 166 5 jc jc PROPN dti-1423 166 6 , , PUNCT dti-1423 166 7 li li PROPN dti-1423 166 8 jx jx PROPN dti-1423 166 9 . . PUNCT dti-1423 167 1 agmatine agmatine PROPN dti-1423 167 2 attenuates attenuate VERB dti-1423 167 3 methamphetamine methamphetamine NOUN dti-1423 167 4 - - PUNCT dti-1423 167 5 induced induce VERB dti-1423 167 6 conditioned condition VERB dti-1423 167 7 place place NOUN dti-1423 167 8 preference preference NOUN dti-1423 167 9 in in ADP dti-1423 167 10 rats rat NOUN dti-1423 167 11 . . PUNCT dti-1423 168 1 eur eur PROPN dti-1423 168 2 j j PROPN dti-1423 168 3 pharmacol pharmacol PROPN dti-1423 168 4 . . PUNCT dti-1423 169 1 2012;680(1–3):69–72 2012;680(1–3):69–72 NUM dti-1423 169 2 . . NOUN dti-1423 169 3 24 24 NUM dti-1423 169 4 . . PUNCT dti-1423 170 1 nguyen nguyen PROPN dti-1423 170 2 l l PROPN dti-1423 170 3 , , PUNCT dti-1423 170 4 kaushal kaushal PROPN dti-1423 170 5 n n CCONJ dti-1423 170 6 , , PUNCT dti-1423 170 7 robson robson PROPN dti-1423 170 8 mj mj PROPN dti-1423 170 9 , , PUNCT dti-1423 170 10 matsumoto matsumoto PROPN dti-1423 170 11 rr rr PROPN dti-1423 170 12 . . PUNCT dti-1423 171 1 sigma sigma PROPN dti-1423 171 2 receptors receptor NOUN dti-1423 171 3 as as ADP dti-1423 171 4 potential potential ADJ dti-1423 171 5 therapeutic therapeutic ADJ dti-1423 171 6 targets target NOUN dti-1423 171 7 for for ADP dti-1423 171 8 neuroprotection neuroprotection NOUN dti-1423 171 9 . . PUNCT dti-1423 172 1 eur eur PROPN dti-1423 172 2 j j PROPN dti-1423 172 3 pharmacol pharmacol PROPN dti-1423 172 4 . . PUNCT dti-1423 173 1 2014;743:42–47 2014;743:42–47 NUM dti-1423 173 2 . . PROPN dti-1423 173 3 25 25 NUM dti-1423 173 4 . . PUNCT dti-1423 174 1 segal segal PROPN dti-1423 174 2 ds ds PROPN dti-1423 174 3 , , PUNCT dti-1423 174 4 kuczenski kuczenski PROPN dti-1423 174 5 r. r. PROPN dti-1423 174 6 repeated repeat VERB dti-1423 174 7 binge binge ADJ dti-1423 174 8 exposures exposure NOUN dti-1423 174 9 to to ADP dti-1423 174 10 amphetamine amphetamine VERB dti-1423 174 11 and and CCONJ dti-1423 174 12 methamphetamine methamphetamine NOUN dti-1423 174 13 : : PUNCT dti-1423 174 14 behavioral behavioral ADJ dti-1423 174 15 and and CCONJ dti-1423 174 16 neurochemical neurochemical ADJ dti-1423 174 17 characterization characterization NOUN dti-1423 174 18 . . PUNCT dti-1423 175 1 j j PROPN dti-1423 175 2 pharmacol pharmacol PROPN dti-1423 175 3 exp exp NOUN dti-1423 175 4 ther ther ADV dti-1423 175 5 . . PUNCT dti-1423 176 1 1997;282(2):561–573 1997;282(2):561–573 NUM dti-1423 176 2 . . NOUN dti-1423 176 3 26 26 NUM dti-1423 176 4 . . PUNCT dti-1423 177 1 berridge berridge PROPN dti-1423 177 2 cw cw PROPN dti-1423 177 3 . . PROPN dti-1423 177 4 neural neural ADJ dti-1423 177 5 substrates substrate NOUN dti-1423 177 6 of of ADP dti-1423 177 7 psychostimulant psychostimulant NOUN dti-1423 177 8 - - PUNCT dti-1423 177 9 induced induce VERB dti-1423 177 10 arousal arousal NOUN dti-1423 177 11 . . PUNCT dti-1423 178 1 neuropsychopharmacology neuropsychopharmacology PROPN dti-1423 178 2 . . PUNCT dti-1423 179 1 2006;31(11):2332–2340 2006;31(11):2332–2340 NUM dti-1423 179 2 . . PUNCT dti-1423 180 1 27 27 NUM dti-1423 180 2 . . PUNCT dti-1423 181 1 kitanaka kitanaka PROPN dti-1423 181 2 n n CCONJ dti-1423 181 3 , , PUNCT dti-1423 181 4 kitanaka kitanaka PROPN dti-1423 181 5 j j PROPN dti-1423 181 6 , , PUNCT dti-1423 181 7 takemura takemura VERB dti-1423 181 8 m. m. NOUN dti-1423 181 9 behavioral behavioral ADJ dti-1423 181 10 sensitization sensitization NOUN dti-1423 181 11 and and CCONJ dti-1423 181 12 alteration alteration NOUN dti-1423 181 13 in in ADP dti-1423 181 14 monoamine monoamine ADJ dti-1423 181 15 metabolism metabolism NOUN dti-1423 181 16 in in ADP dti-1423 181 17 mice mouse NOUN dti-1423 181 18 after after ADP dti-1423 181 19 single single ADJ dti-1423 181 20 versus versus ADP dti-1423 181 21 repeated repeat VERB dti-1423 181 22 methamphetamine methamphetamine NOUN dti-1423 181 23 administration administration NOUN dti-1423 181 24 . . PUNCT dti-1423 182 1 eur eur PROPN dti-1423 182 2 j j PROPN dti-1423 182 3 pharmacol pharmacol PROPN dti-1423 182 4 . . PUNCT dti-1423 183 1 2003;474(1):63–70 2003;474(1):63–70 NUM dti-1423 183 2 . . PUNCT dti-1423 184 1 28 28 NUM dti-1423 184 2 . . PUNCT dti-1423 185 1 kitanaka kitanaka PROPN dti-1423 185 2 n n CCONJ dti-1423 185 3 , , PUNCT dti-1423 185 4 kitanaka kitanaka PROPN dti-1423 185 5 j j PROPN dti-1423 185 6 , , PUNCT dti-1423 185 7 tatsuta tatsuta PROPN dti-1423 185 8 t t PROPN dti-1423 185 9 , , PUNCT dti-1423 185 10 watabe watabe PROPN dti-1423 185 11 k k PROPN dti-1423 185 12 , , PUNCT dti-1423 185 13 morita morita PROPN dti-1423 185 14 y y PROPN dti-1423 185 15 , , PUNCT dti-1423 185 16 takemura takemura VERB dti-1423 185 17 m. m. NOUN dti-1423 185 18 methamphetamine methamphetamine NOUN dti-1423 185 19 reward reward NOUN dti-1423 185 20 in in ADP dti-1423 185 21 mice mouse NOUN dti-1423 185 22 as as SCONJ dti-1423 185 23 assessed assess VERB dti-1423 185 24 by by ADP dti-1423 185 25 conditioned condition VERB dti-1423 185 26 place place NOUN dti-1423 185 27 preference preference NOUN dti-1423 185 28 test test NOUN dti-1423 185 29 with with ADP dti-1423 185 30 supermex supermex NOUN dti-1423 185 31 sensors sensor NOUN dti-1423 185 32 : : PUNCT dti-1423 185 33 effect effect NOUN dti-1423 185 34 of of ADP dti-1423 185 35 subchronic subchronic ADJ dti-1423 185 36 clorgyline clorgyline PROPN dti-1423 185 37 pretreatment pretreatment NOUN dti-1423 185 38 . . PUNCT dti-1423 186 1 neurochem neurochem PROPN dti-1423 186 2 res re NOUN dti-1423 186 3 . . PUNCT dti-1423 187 1 2006;31(6):805–813 2006;31(6):805–813 NUM dti-1423 187 2 . . PROPN dti-1423 187 3 29 29 NUM dti-1423 187 4 . . PUNCT dti-1423 188 1 itzhak itzhak PROPN dti-1423 188 2 y y PROPN dti-1423 188 3 , , PUNCT dti-1423 188 4 martin martin PROPN dti-1423 188 5 jl jl PROPN dti-1423 188 6 . . PUNCT dti-1423 189 1 effect effect NOUN dti-1423 189 2 of of ADP dti-1423 189 3 riluzole riluzole NOUN dti-1423 189 4 and and CCONJ dti-1423 189 5 gabapentin gabapentin NOUN dti-1423 189 6 on on ADP dti-1423 189 7 cocaineand cocaineand PROPN dti-1423 189 8 methamphetamine methamphetamine NOUN dti-1423 189 9 - - PUNCT dti-1423 189 10 induced induce VERB dti-1423 189 11 behavioral behavioral ADJ dti-1423 189 12 sensitization sensitization NOUN dti-1423 189 13 in in ADP dti-1423 189 14 mice mouse NOUN dti-1423 189 15 . . PUNCT dti-1423 190 1 psychopharmacology psychopharmacology NOUN dti-1423 190 2 . . PUNCT dti-1423 191 1 2000;151(2–3):226–233 2000;151(2–3):226–233 NUM dti-1423 191 2 . . X dti-1423 191 3 30 30 NUM dti-1423 191 4 . . PUNCT dti-1423 192 1 niwa niwa PROPN dti-1423 192 2 m m PROPN dti-1423 192 3 , , PUNCT dti-1423 192 4 nitta nitta PROPN dti-1423 192 5 a a PRON dti-1423 192 6 , , PUNCT dti-1423 192 7 mizoguchi mizoguchi PROPN dti-1423 192 8 h h PROPN dti-1423 192 9 , , PUNCT dti-1423 192 10 et et PROPN dti-1423 192 11 al al PROPN dti-1423 192 12 . . PUNCT dti-1423 193 1 a a DET dti-1423 193 2 novel novel ADJ dti-1423 193 3 molecule molecule NOUN dti-1423 193 4 “ " PUNCT dti-1423 193 5 shati shati NOUN dti-1423 193 6 ” " PUNCT dti-1423 193 7 is be AUX dti-1423 193 8 involved involve VERB dti-1423 193 9 in in ADP dti-1423 193 10 methamphetamine methamphetamine NOUN dti-1423 193 11 - - PUNCT dti-1423 193 12 induced induce VERB dti-1423 193 13 hyperlocomotion hyperlocomotion NOUN dti-1423 193 14 , , PUNCT dti-1423 193 15 sensitization sensitization NOUN dti-1423 193 16 , , PUNCT dti-1423 193 17 and and CCONJ dti-1423 193 18 conditioned condition VERB dti-1423 193 19 place place NOUN dti-1423 193 20 preference preference NOUN dti-1423 193 21 . . PUNCT dti-1423 194 1 j j PROPN dti-1423 194 2 neurosci neurosci PROPN dti-1423 194 3 . . PUNCT dti-1423 195 1 2007;27(28):7604–7615 2007;27(28):7604–7615 NUM dti-1423 195 2 . . PROPN dti-1423 195 3 31 31 NUM dti-1423 195 4 . . PUNCT dti-1423 195 5 mori mori PROPN dti-1423 195 6 t t PROPN dti-1423 195 7 , , PUNCT dti-1423 195 8 ito ito PROPN dti-1423 195 9 s s PROPN dti-1423 195 10 , , PUNCT dti-1423 195 11 kita kita PROPN dti-1423 195 12 t t PROPN dti-1423 195 13 , , PUNCT dti-1423 195 14 narita narita PROPN dti-1423 195 15 m m PROPN dti-1423 195 16 , , PUNCT dti-1423 195 17 suzuki suzuki PROPN dti-1423 195 18 t t PROPN dti-1423 195 19 , , PUNCT dti-1423 195 20 sawaguchi sawaguchi ADJ dti-1423 195 21 t. t. NOUN dti-1423 195 22 effects effect NOUN dti-1423 195 23 of of ADP dti-1423 195 24 mu- mu- NOUN dti-1423 195 25 , , PUNCT dti-1423 195 26 delta delta NOUN dti-1423 195 27 and and CCONJ dti-1423 195 28 kappa kappa ADJ dti-1423 195 29 - - ADJ dti-1423 195 30 opioid opioid ADJ dti-1423 195 31 receptor receptor NOUN dti-1423 195 32 agonists agonist NOUN dti-1423 195 33 on on ADP dti-1423 195 34 methamphetamine methamphetamine NOUN dti-1423 195 35 - - PUNCT dti-1423 195 36 induced induce VERB dti-1423 195 37 self self NOUN dti-1423 195 38 - - PUNCT dti-1423 195 39 injurious injurious ADJ dti-1423 195 40 behavior behavior NOUN dti-1423 195 41 in in ADP dti-1423 195 42 mice mouse NOUN dti-1423 195 43 . . PUNCT dti-1423 196 1 eur eur PROPN dti-1423 196 2 j j PROPN dti-1423 196 3 pharmacol pharmacol PROPN dti-1423 196 4 . . PUNCT dti-1423 197 1 2006;532(1–2):81–87 2006;532(1–2):81–87 NUM dti-1423 197 2 . . PUNCT dti-1423 198 1 32 32 NUM dti-1423 198 2 . . PUNCT dti-1423 199 1 kitanaka kitanaka PROPN dti-1423 199 2 n n CCONJ dti-1423 199 3 , , PUNCT dti-1423 199 4 kitanaka kitanaka PROPN dti-1423 199 5 j j PROPN dti-1423 199 6 , , PUNCT dti-1423 199 7 hall hall PROPN dti-1423 199 8 fs fs PROPN dti-1423 199 9 , , PUNCT dti-1423 199 10 et et PROPN dti-1423 199 11 al al PROPN dti-1423 199 12 . . PUNCT dti-1423 200 1 agmatine agmatine PROPN dti-1423 200 2 attenuates attenuate VERB dti-1423 200 3 methamphetamineinduced methamphetamineinduce VERB dti-1423 200 4 hyperlocomotion hyperlocomotion NOUN dti-1423 200 5 and and CCONJ dti-1423 200 6 stereotyped stereotype VERB dti-1423 200 7 behavior behavior NOUN dti-1423 200 8 in in ADP dti-1423 200 9 mice mouse NOUN dti-1423 200 10 . . PUNCT dti-1423 201 1 behav behav PROPN dti-1423 201 2 pharmacol pharmacol PROPN dti-1423 201 3 . . PUNCT dti-1423 201 4 2014 2014 NUM dti-1423 201 5 ; ; PUNCT dti-1423 202 1 25(2):158–165 25(2):158–165 PROPN dti-1423 202 2 . . PUNCT dti-1423 203 1 33 33 NUM dti-1423 203 2 . . PUNCT dti-1423 204 1 kitanaka kitanaka PROPN dti-1423 204 2 j j PROPN dti-1423 204 3 , , PUNCT dti-1423 204 4 kitanaka kitanaka PROPN dti-1423 204 5 n n CCONJ dti-1423 204 6 , , PUNCT dti-1423 204 7 hall hall PROPN dti-1423 204 8 fs fs PROPN dti-1423 204 9 , , PUNCT dti-1423 204 10 et et PROPN dti-1423 204 11 al al PROPN dti-1423 204 12 . . PUNCT dti-1423 205 1 pretreatment pretreatment NOUN dti-1423 205 2 with with ADP dti-1423 205 3 nomifensine nomifensine ADJ dti-1423 205 4 or or CCONJ dti-1423 205 5 nomifensine nomifensine ADJ dti-1423 205 6 analogue analogue NOUN dti-1423 205 7 4 4 NUM dti-1423 205 8 - - PUNCT dti-1423 205 9 phenyl-1,2,3,4 phenyl-1,2,3,4 NUM dti-1423 205 10 - - PUNCT dti-1423 205 11 tetrahydroisoquinoline tetrahydroisoquinoline NOUN dti-1423 205 12 augments augment VERB dti-1423 205 13 methamphetamineinduced methamphetamineinduced ADJ dti-1423 205 14 stereotypical stereotypical ADJ dti-1423 205 15 behavior behavior NOUN dti-1423 205 16 in in ADP dti-1423 205 17 mice mouse NOUN dti-1423 205 18 . . PUNCT dti-1423 206 1 brain brain NOUN dti-1423 206 2 res re NOUN dti-1423 206 3 . . PUNCT dti-1423 207 1 2012;1439:15–26 2012;1439:15–26 PROPN dti-1423 207 2 . . PUNCT dti-1423 208 1 34 34 NUM dti-1423 208 2 . . PUNCT dti-1423 209 1 horner horner PROPN dti-1423 209 2 ka ka PROPN dti-1423 209 3 , , PUNCT dti-1423 209 4 noble noble ADJ dti-1423 209 5 es es NOUN dti-1423 209 6 , , PUNCT dti-1423 209 7 gilbert gilbert PROPN dti-1423 209 8 ye ye PROPN dti-1423 209 9 . . PROPN dti-1423 209 10 methamphetamine methamphetamine NOUN dti-1423 209 11 - - PUNCT dti-1423 209 12 induced induce VERB dti-1423 209 13 stereotypy stereotypy NOUN dti-1423 209 14 correlates correlate VERB dti-1423 209 15 negatively negatively ADV dti-1423 209 16 with with ADP dti-1423 209 17 patch patch NOUN dti-1423 209 18 - - PUNCT dti-1423 209 19 enhanced enhance VERB dti-1423 209 20 prodynorphin prodynorphin NOUN dti-1423 209 21 and and CCONJ dti-1423 209 22 arc arc NOUN dti-1423 209 23 mrna mrna NOUN dti-1423 209 24 expression expression NOUN dti-1423 209 25 in in ADP dti-1423 209 26 the the DET dti-1423 209 27 rat rat NOUN dti-1423 209 28 caudate caudate NOUN dti-1423 209 29 putamen putaman NOUN dti-1423 209 30 : : PUNCT dti-1423 209 31 the the DET dti-1423 209 32 role role NOUN dti-1423 209 33 of of ADP dti-1423 209 34 mu mu PROPN dti-1423 209 35 opioid opioid ADJ dti-1423 209 36 receptor receptor NOUN dti-1423 209 37 activation activation NOUN dti-1423 209 38 . . PUNCT dti-1423 210 1 pharmacol pharmacol PROPN dti-1423 210 2 biochem biochem PROPN dti-1423 210 3 behav behav NOUN dti-1423 210 4 . . PUNCT dti-1423 211 1 2010;95(4):410–421 2010;95(4):410–421 NUM dti-1423 211 2 . . PROPN dti-1423 211 3 35 35 NUM dti-1423 211 4 . . PUNCT dti-1423 211 5 tatsuta tatsuta PROPN dti-1423 211 6 t t PROPN dti-1423 211 7 , , PUNCT dti-1423 211 8 kitanaka kitanaka PROPN dti-1423 211 9 n n CCONJ dti-1423 211 10 , , PUNCT dti-1423 211 11 kitanaka kitanaka PROPN dti-1423 211 12 j j PROPN dti-1423 211 13 , , PUNCT dti-1423 211 14 morita morita PROPN dti-1423 211 15 y y PROPN dti-1423 211 16 , , PUNCT dti-1423 211 17 takemura takemura VERB dti-1423 211 18 m. m. NOUN dti-1423 211 19 lobeline lobeline NOUN dti-1423 211 20 attenuates attenuate VERB dti-1423 211 21 methamphetamine methamphetamine NOUN dti-1423 211 22 - - PUNCT dti-1423 211 23 induced induce VERB dti-1423 211 24 stereotypy stereotypy NOUN dti-1423 211 25 in in ADP dti-1423 211 26 adolescent adolescent ADJ dti-1423 211 27 mice mouse NOUN dti-1423 211 28 . . PUNCT dti-1423 212 1 neurochem neurochem PROPN dti-1423 212 2 res re NOUN dti-1423 212 3 . . PUNCT dti-1423 213 1 2006 2006 NUM dti-1423 213 2 ; ; PUNCT dti-1423 213 3 31(11):1359–1369 31(11):1359–1369 NUM dti-1423 213 4 . . PUNCT dti-1423 214 1 36 36 NUM dti-1423 214 2 . . PUNCT dti-1423 215 1 joshi joshi PROPN dti-1423 215 2 vv vv PROPN dti-1423 215 3 , , PUNCT dti-1423 215 4 balsara balsara PROPN dti-1423 215 5 jj jj PROPN dti-1423 215 6 , , PUNCT dti-1423 215 7 jadhav jadhav PROPN dti-1423 215 8 jh jh PROPN dti-1423 215 9 , , PUNCT dti-1423 215 10 chandorkar chandorkar PROPN dti-1423 215 11 ag ag PROPN dti-1423 215 12 . . PROPN dti-1423 215 13 effect effect NOUN dti-1423 215 14 of of ADP dti-1423 215 15 l l NOUN dti-1423 215 16 - - NOUN dti-1423 215 17 histidine histidine ADJ dti-1423 215 18 and and CCONJ dti-1423 215 19 chlorcyclizine chlorcyclizine NOUN dti-1423 215 20 on on ADP dti-1423 215 21 apomorphine apomorphine NOUN dti-1423 215 22 - - PUNCT dti-1423 215 23 induced induce VERB dti-1423 215 24 climbing climbing NOUN dti-1423 215 25 behaviour behaviour NOUN dti-1423 215 26 and and CCONJ dti-1423 215 27 methamphetamine methamphetamine NOUN dti-1423 215 28 stereotypy stereotypy PROPN dti-1423 215 29 in in ADP dti-1423 215 30 mice mouse NOUN dti-1423 215 31 . . PUNCT dti-1423 216 1 eur eur PROPN dti-1423 216 2 j j PROPN dti-1423 216 3 pharmacol pharmacol PROPN dti-1423 216 4 . . PUNCT dti-1423 217 1 1981;69(4):499–502 1981;69(4):499–502 NUM dti-1423 217 2 . . PUNCT dti-1423 218 1 37 37 NUM dti-1423 218 2 . . PUNCT dti-1423 218 3 mori mori PROPN dti-1423 218 4 t t PROPN dti-1423 218 5 , , PUNCT dti-1423 218 6 ito ito PROPN dti-1423 218 7 s s PROPN dti-1423 218 8 , , PUNCT dti-1423 218 9 kita kita PROPN dti-1423 218 10 t t PROPN dti-1423 218 11 , , PUNCT dti-1423 218 12 sawaguchi sawaguchi ADJ dti-1423 218 13 t. t. NOUN dti-1423 218 14 effects effect NOUN dti-1423 218 15 of of ADP dti-1423 218 16 dopamineand dopamineand NOUN dti-1423 218 17 serotonin serotonin NOUN dti-1423 218 18 - - PUNCT dti-1423 218 19 related relate VERB dti-1423 218 20 compounds compound NOUN dti-1423 218 21 on on ADP dti-1423 218 22 methamphetamine methamphetamine NOUN dti-1423 218 23 - - PUNCT dti-1423 218 24 induced induce VERB dti-1423 218 25 self self NOUN dti-1423 218 26 - - PUNCT dti-1423 218 27 injurious injurious ADJ dti-1423 218 28 behavior behavior NOUN dti-1423 218 29 in in ADP dti-1423 218 30 mice mouse NOUN dti-1423 218 31 . . PUNCT dti-1423 219 1 j j PROPN dti-1423 219 2     SPACE dti-1423 219 3 pharmacol pharmacol PROPN dti-1423 219 4 sci sci PROPN dti-1423 219 5 . . PUNCT dti-1423 219 6 2004;96(4):459–464 2004;96(4):459–464 NUM dti-1423 219 7 . . PUNCT dti-1423 219 8 http://www.la-press.com http://www.la-press.com X dti-1423 220 1 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 AUX dti-1423 220 2 http://www.drugabuse.gov/publications/drugfacts/methamphetamine http://www.drugabuse.gov/publications/drugfacts/methamphetamine PROPN dti-1423 220 3 http://www.drugabuse.gov/publications/drugfacts/methamphetamine http://www.drugabuse.gov/publications/drugfacts/methamphetamine PROPN dti-1423 220 4 kitanaka kitanaka PROPN dti-1423 220 5 et et PROPN dti-1423 220 6 al al PROPN dti-1423 220 7 6 6 NUM dti-1423 220 8 drug drug NOUN dti-1423 220 9 target target NOUN dti-1423 220 10 insights insight NOUN dti-1423 220 11 2016:10 2016:10 NUM dti-1423 220 12 38 38 NUM dti-1423 220 13 . . PUNCT dti-1423 221 1 tatsuta tatsuta PROPN dti-1423 221 2 t t PROPN dti-1423 221 3 , , PUNCT dti-1423 221 4 kitanaka kitanaka PROPN dti-1423 221 5 n n CCONJ dti-1423 221 6 , , PUNCT dti-1423 221 7 kitanaka kitanaka PROPN dti-1423 221 8 j j PROPN dti-1423 221 9 , , PUNCT dti-1423 221 10 morita morita PROPN dti-1423 221 11 y y PROPN dti-1423 221 12 , , PUNCT dti-1423 221 13 takemura takemura VERB dti-1423 221 14 m. m. NOUN dti-1423 221 15 lack lack NOUN dti-1423 221 16 of of ADP dti-1423 221 17 effect effect NOUN dti-1423 221 18 of of ADP dti-1423 221 19 anticonvulsant anticonvulsant ADJ dti-1423 221 20 topiramate topiramate NOUN dti-1423 221 21 on on ADP dti-1423 221 22 methamphetamine methamphetamine NOUN dti-1423 221 23 - - PUNCT dti-1423 221 24 induced induce VERB dti-1423 221 25 stereotypy stereotypy NOUN dti-1423 221 26 and and CCONJ dti-1423 221 27 rewarding rewarding ADJ dti-1423 221 28 property property NOUN dti-1423 221 29 in in ADP dti-1423 221 30 mice mouse NOUN dti-1423 221 31 . . PUNCT dti-1423 222 1 pharmacol pharmacol PROPN dti-1423 222 2 biochem biochem PROPN dti-1423 222 3 behav behav NOUN dti-1423 222 4 . . PUNCT dti-1423 223 1 2007;87(1):48–55 2007;87(1):48–55 X dti-1423 223 2 . . PUNCT dti-1423 223 3 39 39 NUM dti-1423 223 4 . . PUNCT dti-1423 224 1 kitanaka kitanaka PROPN dti-1423 224 2 j j PROPN dti-1423 224 3 , , PUNCT dti-1423 224 4 kitanaka kitanaka PROPN dti-1423 224 5 n n CCONJ dti-1423 224 6 , , PUNCT dti-1423 224 7 tatsuta tatsuta PROPN dti-1423 224 8 t t PROPN dti-1423 224 9 , , PUNCT dti-1423 224 10 et et PROPN dti-1423 224 11 al al PROPN dti-1423 224 12 . . PUNCT dti-1423 224 13 sigma1 sigma1 PROPN dti-1423 225 1 receptor receptor NOUN dti-1423 225 2 antagonists antagonist NOUN dti-1423 225 3 determine determine VERB dti-1423 225 4 the the DET dti-1423 225 5 behavioral behavioral ADJ dti-1423 225 6 pattern pattern NOUN dti-1423 225 7 of of ADP dti-1423 225 8 the the DET dti-1423 225 9 methamphetamine methamphetamine NOUN dti-1423 225 10 - - PUNCT dti-1423 225 11 induced induce VERB dti-1423 225 12 stereotypy stereotypy NOUN dti-1423 225 13 in in ADP dti-1423 225 14 mice mouse NOUN dti-1423 225 15 . . PUNCT dti-1423 226 1 psychopharmacology psychopharmacology NOUN dti-1423 226 2 . . PUNCT dti-1423 227 1 2009;203(4):781–792 2009;203(4):781–792 NUM dti-1423 227 2 . . NOUN dti-1423 227 3 40 40 NUM dti-1423 227 4 . . PUNCT dti-1423 227 5 gianutsos gianutsos PROPN dti-1423 227 6 g g PROPN dti-1423 227 7 , , PUNCT dti-1423 227 8 morrow morrow NOUN dti-1423 227 9 g g PROPN dti-1423 227 10 , , PUNCT dti-1423 227 11 light light NOUN dti-1423 227 12 s s PROPN dti-1423 227 13 , , PUNCT dti-1423 227 14 sweeney sweeney PROPN dti-1423 227 15 mj mj PROPN dti-1423 227 16 . . PUNCT dti-1423 228 1 dopaminergic dopaminergic ADJ dti-1423 228 2 properties property NOUN dti-1423 228 3 of of ADP dti-1423 228 4 nomifensine nomifensine NOUN dti-1423 228 5 . . PUNCT dti-1423 229 1 pharmacol pharmacol PROPN dti-1423 229 2 biochem biochem PROPN dti-1423 229 3 behav behav NOUN dti-1423 229 4 . . PUNCT dti-1423 230 1 1982;17(5):951–954 1982;17(5):951–954 NUM dti-1423 230 2 . . X dti-1423 230 3 41 41 NUM dti-1423 230 4 . . PUNCT dti-1423 231 1 kitanaka kitanaka PROPN dti-1423 231 2 n n CCONJ dti-1423 231 3 , , PUNCT dti-1423 231 4 kitanaka kitanaka PROPN dti-1423 231 5 j j PROPN dti-1423 231 6 , , PUNCT dti-1423 231 7 takemura takemura VERB dti-1423 231 8 m. m. NOUN dti-1423 231 9 inhibition inhibition NOUN dti-1423 231 10 of of ADP dti-1423 231 11 methamphetamine methamphetamine NOUN dti-1423 231 12 - - PUNCT dti-1423 231 13 induced induce VERB dti-1423 231 14 hyperlocomotion hyperlocomotion NOUN dti-1423 231 15 in in ADP dti-1423 231 16 mice mouse NOUN dti-1423 231 17 by by ADP dti-1423 231 18 clorgyline clorgyline PROPN dti-1423 231 19 , , PUNCT dti-1423 231 20 a a DET dti-1423 231 21 monoamine monoamine NOUN dti-1423 231 22 oxidase oxidase NOUN dti-1423 231 23 - - PUNCT dti-1423 231 24 a a DET dti-1423 231 25 inhibitor inhibitor NOUN dti-1423 231 26 , , PUNCT dti-1423 231 27 through through ADP dti-1423 231 28 alteration alteration NOUN dti-1423 231 29 of of ADP dti-1423 231 30 the the DET dti-1423 231 31 5 5 NUM dti-1423 231 32 - - PUNCT dti-1423 231 33 hydroxytryptamine hydroxytryptamine NOUN dti-1423 231 34 turnover turnover NOUN dti-1423 231 35 in in ADP dti-1423 231 36 the the DET dti-1423 231 37 striatum striatum NOUN dti-1423 231 38 . . PUNCT dti-1423 232 1 neuroscience neuroscience NOUN dti-1423 232 2 . . PUNCT dti-1423 233 1 2005;130(2):295–308 2005;130(2):295–308 NUM dti-1423 233 2 . . X dti-1423 234 1 42 42 NUM dti-1423 234 2 . . PUNCT dti-1423 235 1 amin amin PROPN dti-1423 235 2 k. k. PROPN dti-1423 236 1 the the DET dti-1423 236 2 role role NOUN dti-1423 236 3 of of ADP dti-1423 236 4 mast mast NOUN dti-1423 236 5 cells cell NOUN dti-1423 236 6 in in ADP dti-1423 236 7 allergic allergic ADJ dti-1423 236 8 inflammation inflammation NOUN dti-1423 236 9 . . PUNCT dti-1423 237 1 respir respir VERB dti-1423 237 2 med med ADJ dti-1423 237 3 . . PUNCT dti-1423 238 1 2012;106(1 2012;106(1 NUM dti-1423 238 2 ): ): PUNCT dti-1423 238 3 9–14 9–14 PROPN dti-1423 238 4 . . PUNCT dti-1423 239 1 43 43 NUM dti-1423 239 2 . . PUNCT dti-1423 240 1 cataldi cataldi PROPN dti-1423 240 2 m m PROPN dti-1423 240 3 , , PUNCT dti-1423 240 4 borriello borriello PROPN dti-1423 240 5 f f PROPN dti-1423 240 6 , , PUNCT dti-1423 240 7 granata granata PROPN dti-1423 240 8 f f PROPN dti-1423 240 9 , , PUNCT dti-1423 240 10 annunziato annunziato PROPN dti-1423 240 11 l l PROPN dti-1423 240 12 , , PUNCT dti-1423 240 13 marone marone PROPN dti-1423 240 14 g. g. PROPN dti-1423 240 15 histamine histamine NOUN dti-1423 240 16 receptors receptor NOUN dti-1423 240 17 and and CCONJ dti-1423 240 18 antihistamines antihistamine NOUN dti-1423 240 19 : : PUNCT dti-1423 240 20 from from ADP dti-1423 240 21 discovery discovery NOUN dti-1423 240 22 to to ADP dti-1423 240 23 clinical clinical ADJ dti-1423 240 24 applications application NOUN dti-1423 240 25 . . PUNCT dti-1423 241 1 chem chem NOUN dti-1423 241 2 immunol immunol NOUN dti-1423 241 3 allergy allergy NOUN dti-1423 241 4 . . PUNCT dti-1423 242 1 2014;100:214–226 2014;100:214–226 NUM dti-1423 242 2 . . PUNCT dti-1423 243 1 44 44 NUM dti-1423 243 2 . . PUNCT dti-1423 244 1 huang huang PROPN dti-1423 244 2 jf jf PROPN dti-1423 244 3 , , PUNCT dti-1423 244 4 thurmond thurmond PROPN dti-1423 244 5 rl rl PROPN dti-1423 244 6 . . PUNCT dti-1423 245 1 the the DET dti-1423 245 2 new new ADJ dti-1423 245 3 biology biology NOUN dti-1423 245 4 of of ADP dti-1423 245 5 histamine histamine NOUN dti-1423 245 6 receptors receptor NOUN dti-1423 245 7 . . PUNCT dti-1423 246 1 curr curr PROPN dti-1423 246 2 allergy allergy PROPN dti-1423 246 3 asthma asthma PROPN dti-1423 246 4 rep rep PROPN dti-1423 246 5 . . PROPN dti-1423 246 6 2008;8(1):21–27 2008;8(1):21–27 NUM dti-1423 246 7 . . PUNCT dti-1423 247 1 45 45 NUM dti-1423 247 2 . . PUNCT dti-1423 248 1 watanabe watanabe PROPN dti-1423 248 2 t t PROPN dti-1423 248 3 , , PUNCT dti-1423 248 4 taguchi taguchi PROPN dti-1423 248 5 y y PROPN dti-1423 248 6 , , PUNCT dti-1423 248 7 hayashi hayashi PROPN dti-1423 248 8 h h PROPN dti-1423 248 9 , , PUNCT dti-1423 248 10 et et PROPN dti-1423 248 11 al al PROPN dti-1423 248 12 . . PROPN dti-1423 248 13 evidence evidence NOUN dti-1423 248 14 for for ADP dti-1423 248 15 the the DET dti-1423 248 16 presence presence NOUN dti-1423 248 17 of of ADP dti-1423 248 18 a a DET dti-1423 248 19 histaminergic histaminergic ADJ dti-1423 248 20 neuron neuron NOUN dti-1423 248 21 system system NOUN dti-1423 248 22 in in ADP dti-1423 248 23 the the DET dti-1423 248 24 rat rat NOUN dti-1423 248 25 brain brain NOUN dti-1423 248 26 : : PUNCT dti-1423 248 27 an an DET dti-1423 248 28 immunohistochemical immunohistochemical ADJ dti-1423 248 29 analysis analysis NOUN dti-1423 248 30 . . PUNCT dti-1423 249 1 neurosci neurosci PROPN dti-1423 249 2 lett lett PROPN dti-1423 249 3 . . PUNCT dti-1423 250 1 1983;39(3):249–254 1983;39(3):249–254 X dti-1423 250 2 . . PROPN dti-1423 251 1 46 46 NUM dti-1423 251 2 . . PUNCT dti-1423 252 1 panula panula PROPN dti-1423 253 1 p p X dti-1423 253 2 , , PUNCT dti-1423 253 3 yang yang PROPN dti-1423 253 4 hy hy PROPN dti-1423 253 5 , , PUNCT dti-1423 253 6 costa costa PROPN dti-1423 253 7 e. e. PROPN dti-1423 253 8 histamine histamine PROPN dti-1423 253 9 - - PUNCT dti-1423 253 10 containing contain VERB dti-1423 253 11 neurons neuron NOUN dti-1423 253 12 in in ADP dti-1423 253 13 the the DET dti-1423 253 14 rat rat NOUN dti-1423 253 15 hypothalamus hypothalamus PROPN dti-1423 253 16 . . PUNCT dti-1423 254 1 proc proc PROPN dti-1423 254 2 natl natl PROPN dti-1423 254 3 acad acad PROPN dti-1423 254 4 sci sci PROPN dti-1423 254 5 u u PROPN dti-1423 254 6 s s PART dti-1423 254 7 a. a. NOUN dti-1423 254 8 1984;81(8):2572–2576 1984;81(8):2572–2576 NUM dti-1423 254 9 . . PUNCT dti-1423 255 1 47 47 NUM dti-1423 255 2 . . PUNCT dti-1423 256 1 prell prell PROPN dti-1423 256 2 gd gd PROPN dti-1423 256 3 , , PUNCT dti-1423 256 4 green green PROPN dti-1423 256 5 jp jp PROPN dti-1423 256 6 . . PUNCT dti-1423 256 7 histamine histamine NOUN dti-1423 256 8 as as ADP dti-1423 256 9 a a DET dti-1423 256 10 neuroregulator neuroregulator NOUN dti-1423 256 11 . . PUNCT dti-1423 257 1 annu annu PROPN dti-1423 257 2 rev rev PROPN dti-1423 257 3 neurosci neurosci PROPN dti-1423 257 4 . . PUNCT dti-1423 258 1 1986;9 1986;9 NUM dti-1423 258 2 : : PUNCT dti-1423 259 1 209–254 209–254 NUM dti-1423 259 2 . . X dti-1423 260 1 48 48 NUM dti-1423 260 2 . . PUNCT dti-1423 260 3 brown brown PROPN dti-1423 260 4 re re PROPN dti-1423 260 5 , , PUNCT dti-1423 260 6 stevens stevens PROPN dti-1423 260 7 dr dr PROPN dti-1423 260 8 , , PUNCT dti-1423 260 9 haas haas PROPN dti-1423 260 10 hl hl PROPN dti-1423 260 11 . . PUNCT dti-1423 261 1 the the DET dti-1423 261 2 physiology physiology NOUN dti-1423 261 3 of of ADP dti-1423 261 4 brain brain NOUN dti-1423 261 5 histamine histamine NOUN dti-1423 261 6 . . PUNCT dti-1423 262 1 prog prog PROPN dti-1423 262 2 neurobiol neurobiol PROPN dti-1423 262 3 . . PUNCT dti-1423 263 1 2001;63(6):637–672 2001;63(6):637–672 NUM dti-1423 263 2 . . NOUN dti-1423 263 3 49 49 NUM dti-1423 263 4 . . PUNCT dti-1423 264 1 haas haas PROPN dti-1423 264 2 hl hl PROPN dti-1423 264 3 , , PUNCT dti-1423 264 4 sergeeva sergeeva PROPN dti-1423 264 5 oa oa INTJ dti-1423 264 6 , , PUNCT dti-1423 264 7 selbach selbach NOUN dti-1423 264 8 o. o. NOUN dti-1423 264 9 histamine histamine NOUN dti-1423 264 10 in in ADP dti-1423 264 11 the the DET dti-1423 264 12 nervous nervous ADJ dti-1423 264 13 system system NOUN dti-1423 264 14 . . PUNCT dti-1423 265 1 physiol physiol PROPN dti-1423 265 2 rev rev VERB dti-1423 265 3 . . PROPN dti-1423 265 4 2008;88(3):1183–1241 2008;88(3):1183–1241 NUM dti-1423 265 5 . . PUNCT dti-1423 266 1 50 50 NUM dti-1423 266 2 . . PUNCT dti-1423 267 1 roberts roberts PROPN dti-1423 267 2 f f PROPN dti-1423 267 3 , , PUNCT dti-1423 267 4 calcutt calcutt PROPN dti-1423 267 5 cr cr PROPN dti-1423 267 6 . . PUNCT dti-1423 267 7 histamine histamine NOUN dti-1423 267 8 and and CCONJ dti-1423 267 9 the the DET dti-1423 267 10 hypothalamus hypothalamus PROPN dti-1423 267 11 . . PUNCT dti-1423 268 1 neuroscience neuroscience NOUN dti-1423 268 2 . . PUNCT dti-1423 269 1 1983;9(4 1983;9(4 NUM dti-1423 269 2 ): ): PUNCT dti-1423 269 3 721–739 721–739 NUM dti-1423 269 4 . . PUNCT dti-1423 270 1 51 51 NUM dti-1423 270 2 . . PUNCT dti-1423 271 1 jones jones PROPN dti-1423 271 2 be be VERB dti-1423 271 3 . . PUNCT dti-1423 272 1 arousal arousal NOUN dti-1423 272 2 systems system NOUN dti-1423 272 3 . . PUNCT dti-1423 273 1 front front PROPN dti-1423 273 2 biosci biosci PROPN dti-1423 273 3 . . PUNCT dti-1423 274 1 2003;8 2003;8 NUM dti-1423 274 2 : : PUNCT dti-1423 274 3 s438 s438 NUM dti-1423 274 4 – – PUNCT dti-1423 274 5 s451 s451 PROPN dti-1423 274 6 . . PROPN dti-1423 275 1 52 52 NUM dti-1423 275 2 . . PUNCT dti-1423 276 1 nuutinen nuutinen PROPN dti-1423 276 2 s s PROPN dti-1423 276 3 , , PUNCT dti-1423 276 4 panula panula VERB dti-1423 276 5 p. p. NOUN dti-1423 276 6 histamine histamine NOUN dti-1423 276 7 in in ADP dti-1423 276 8 neurotransmission neurotransmission NOUN dti-1423 276 9 and and CCONJ dti-1423 276 10 brain brain NOUN dti-1423 276 11 diseases disease NOUN dti-1423 276 12 . . PUNCT dti-1423 277 1 adv adv PROPN dti-1423 277 2 exp exp NOUN dti-1423 277 3 med med ADJ dti-1423 277 4 biol biol NOUN dti-1423 277 5 . . PUNCT dti-1423 278 1 2010;709:95–107 2010;709:95–107 X dti-1423 278 2 . . PROPN dti-1423 279 1 53 53 NUM dti-1423 279 2 . . PUNCT dti-1423 280 1 fukagawa fukagawa PROPN dti-1423 280 2 k k PROPN dti-1423 280 3 , , PUNCT dti-1423 280 4 sakata sakata PROPN dti-1423 280 5 t t PROPN dti-1423 280 6 , , PUNCT dti-1423 280 7 shiraishi shiraishi PROPN dti-1423 280 8 t t PROPN dti-1423 280 9 , , PUNCT dti-1423 280 10 et et PROPN dti-1423 280 11 al al PROPN dti-1423 280 12 . . PUNCT dti-1423 280 13 neuronal neuronal ADJ dti-1423 280 14 histamine histamine NOUN dti-1423 280 15 modulates modulate NOUN dti-1423 280 16 feeding feed VERB dti-1423 280 17 behavior behavior NOUN dti-1423 280 18 through through ADP dti-1423 280 19 h1 h1 NOUN dti-1423 280 20 - - PUNCT dti-1423 280 21 receptor receptor NOUN dti-1423 280 22 in in ADP dti-1423 280 23 rat rat NOUN dti-1423 280 24 hypothalamus hypothalamus PROPN dti-1423 280 25 . . PUNCT dti-1423 281 1 am be AUX dti-1423 281 2 j j PROPN dti-1423 281 3 physiol physiol PROPN dti-1423 281 4 . . PUNCT dti-1423 282 1 1989;256(3 1989;256(3 NUM dti-1423 282 2 pt pt PROPN dti-1423 282 3 2 2 NUM dti-1423 282 4 ): ): PUNCT dti-1423 282 5 r605 r605 PROPN dti-1423 282 6 – – PUNCT dti-1423 282 7 r611 r611 PROPN dti-1423 282 8 . . PROPN dti-1423 283 1 54 54 NUM dti-1423 283 2 . . PUNCT dti-1423 284 1 wada wada PROPN dti-1423 284 2 h h PROPN dti-1423 284 3 , , PUNCT dti-1423 284 4 inagaki inagaki PROPN dti-1423 284 5 n n PRON dti-1423 284 6 , , PUNCT dti-1423 284 7 yamatodani yamatodani PROPN dti-1423 284 8 a a X dti-1423 284 9 , , PUNCT dti-1423 284 10 watanabe watanabe PROPN dti-1423 284 11 t. t. PROPN dti-1423 284 12 is be AUX dti-1423 284 13 the the DET dti-1423 284 14 histaminergic histaminergic ADJ dti-1423 284 15 neuron neuron NOUN dti-1423 284 16 system system NOUN dti-1423 284 17 a a DET dti-1423 284 18 regulatory regulatory ADJ dti-1423 284 19 center center NOUN dti-1423 284 20 for for ADP dti-1423 284 21 whole whole ADJ dti-1423 284 22 - - PUNCT dti-1423 284 23 brain brain NOUN dti-1423 284 24 activity activity NOUN dti-1423 284 25 ? ? PUNCT dti-1423 285 1 trends trend NOUN dti-1423 285 2 neurosci neurosci NOUN dti-1423 285 3 . . PUNCT dti-1423 286 1 1991;14(9 1991;14(9 NUM dti-1423 286 2 ): ): PUNCT dti-1423 286 3 415–418 415–418 NUM dti-1423 286 4 . . PUNCT dti-1423 287 1 55 55 NUM dti-1423 287 2 . . X dti-1423 288 1 ogasawara ogasawara PROPN dti-1423 288 2 m m PROPN dti-1423 288 3 , , PUNCT dti-1423 288 4 yamauchi yamauchi PROPN dti-1423 288 5 k k PROPN dti-1423 288 6 , , PUNCT dti-1423 288 7 satoh satoh PROPN dti-1423 288 8 y y PROPN dti-1423 288 9 , , PUNCT dti-1423 288 10 et et PROPN dti-1423 288 11 al al PROPN dti-1423 288 12 . . PUNCT dti-1423 289 1 recent recent ADJ dti-1423 289 2 advances advance NOUN dti-1423 289 3 in in ADP dti-1423 289 4 molecular molecular ADJ dti-1423 289 5 pharmacology pharmacology NOUN dti-1423 289 6 of of ADP dti-1423 289 7 the the DET dti-1423 289 8 histamine histamine NOUN dti-1423 289 9 systems system NOUN dti-1423 289 10 : : PUNCT dti-1423 289 11 organic organic ADJ dti-1423 289 12 cation cation NOUN dti-1423 289 13 transporters transporter NOUN dti-1423 289 14 as as ADP dti-1423 289 15 a a DET dti-1423 289 16 histamine histamine NOUN dti-1423 289 17 transporter transporter NOUN dti-1423 289 18 and and CCONJ dti-1423 289 19 histamine histamine NOUN dti-1423 289 20 metabolism metabolism NOUN dti-1423 289 21 . . PUNCT dti-1423 290 1 j j PROPN dti-1423 290 2 pharmacol pharmacol PROPN dti-1423 290 3 sci sci PROPN dti-1423 290 4 . . PUNCT dti-1423 291 1 2006;101(1):24–30 2006;101(1):24–30 NUM dti-1423 291 2 . . PUNCT dti-1423 292 1 56 56 NUM dti-1423 292 2 . . PUNCT dti-1423 293 1 yoshikawa yoshikawa PROPN dti-1423 293 2 t t PROPN dti-1423 293 3 , , PUNCT dti-1423 293 4 naganuma naganuma PROPN dti-1423 293 5 f f PROPN dti-1423 293 6 , , PUNCT dti-1423 293 7 iida iida PROPN dti-1423 293 8 t t PROPN dti-1423 293 9 , , PUNCT dti-1423 293 10 et et PROPN dti-1423 293 11 al al PROPN dti-1423 293 12 . . PUNCT dti-1423 294 1 molecular molecular ADJ dti-1423 294 2 mechanism mechanism NOUN dti-1423 294 3 of of ADP dti-1423 294 4 histamine histamine NOUN dti-1423 294 5 clearance clearance NOUN dti-1423 294 6 by by ADP dti-1423 294 7 primary primary ADJ dti-1423 294 8 human human ADJ dti-1423 294 9 astrocytes astrocyte NOUN dti-1423 294 10 . . PUNCT dti-1423 295 1 glia glia NOUN dti-1423 295 2 . . PUNCT dti-1423 296 1 2013;61(6):905–916 2013;61(6):905–916 NUM dti-1423 296 2 . . PUNCT dti-1423 297 1 57 57 NUM dti-1423 297 2 . . PUNCT dti-1423 298 1 takemura takemura PROPN dti-1423 298 2 m m PROPN dti-1423 298 3 , , PUNCT dti-1423 298 4 imamura imamura PROPN dti-1423 298 5 i i PROPN dti-1423 298 6 , , PUNCT dti-1423 298 7 mizuguchi mizuguchi PROPN dti-1423 298 8 h h PROPN dti-1423 298 9 , , PUNCT dti-1423 298 10 fukui fukui PROPN dti-1423 298 11 h h PROPN dti-1423 298 12 , , PUNCT dti-1423 298 13 yamatodani yamatodani PROPN dti-1423 298 14 a. a. NOUN dti-1423 298 15 tissue tissue NOUN dti-1423 298 16 distribution distribution NOUN dti-1423 298 17 of of ADP dti-1423 298 18 histamine histamine NOUN dti-1423 298 19 n n CCONJ dti-1423 298 20 - - PUNCT dti-1423 298 21 methyltransferase methyltransferase NOUN dti-1423 298 22 - - PUNCT dti-1423 298 23 like like ADJ dti-1423 298 24 immunoreactivity immunoreactivity NOUN dti-1423 298 25 in in ADP dti-1423 298 26 rodents rodent NOUN dti-1423 298 27 . . PUNCT dti-1423 299 1 life life NOUN dti-1423 299 2 sci sci PROPN dti-1423 299 3 . . PUNCT dti-1423 300 1 1994;54(15):1059–1071 1994;54(15):1059–1071 NUM dti-1423 300 2 . . PUNCT dti-1423 301 1 58 58 NUM dti-1423 301 2 . . PUNCT dti-1423 302 1 kitanaka kitanaka PROPN dti-1423 302 2 n n CCONJ dti-1423 302 3 , , PUNCT dti-1423 302 4 kitanaka kitanaka PROPN dti-1423 302 5 j j PROPN dti-1423 302 6 , , PUNCT dti-1423 302 7 oue oue PROPN dti-1423 302 8 t t PROPN dti-1423 302 9 , , PUNCT dti-1423 302 10 tada tada PROPN dti-1423 302 11 y y PROPN dti-1423 302 12 , , PUNCT dti-1423 302 13 tanaka tanaka PROPN dti-1423 302 14 t t PROPN dti-1423 302 15 , , PUNCT dti-1423 302 16 takemura takemura VERB dti-1423 302 17 m. m. NOUN dti-1423 302 18 genomic genomic NOUN dti-1423 302 19 structure structure NOUN dti-1423 302 20 of of ADP dti-1423 302 21 the the DET dti-1423 302 22 rat rat NOUN dti-1423 302 23 and and CCONJ dti-1423 302 24 mouse mouse NOUN dti-1423 302 25 histamine histamine NOUN dti-1423 302 26 n n CCONJ dti-1423 302 27 - - PUNCT dti-1423 302 28 methyltransferase methyltransferase NOUN dti-1423 302 29 gene gene NOUN dti-1423 302 30 . . PUNCT dti-1423 303 1 jpn jpn PROPN dti-1423 303 2 j j PROPN dti-1423 303 3 pharmacol pharmacol PROPN dti-1423 303 4 . . PUNCT dti-1423 304 1 2002;88(1):85–92 2002;88(1):85–92 X dti-1423 304 2 . . NOUN dti-1423 304 3 59 59 NUM dti-1423 304 4 . . PUNCT dti-1423 305 1 kitanaka kitanaka PROPN dti-1423 305 2 j j PROPN dti-1423 305 3 , , PUNCT dti-1423 305 4 kitanaka kitanaka PROPN dti-1423 305 5 n n PRON dti-1423 305 6 , , PUNCT dti-1423 305 7 tsujimura tsujimura PROPN dti-1423 305 8 t t PROPN dti-1423 305 9 , , PUNCT dti-1423 305 10 terada terada PROPN dti-1423 305 11 n n CCONJ dti-1423 305 12 , , PUNCT dti-1423 305 13 takemura takemura VERB dti-1423 305 14 m. m. NOUN dti-1423 305 15 expression expression NOUN dti-1423 305 16 of of ADP dti-1423 305 17 diamine diamine ADJ dti-1423 305 18 oxidase oxidase NOUN dti-1423 305 19 ( ( PUNCT dti-1423 305 20 histaminase histaminase PROPN dti-1423 305 21 ) ) PUNCT dti-1423 305 22 in in ADP dti-1423 305 23 guinea guinea NOUN dti-1423 305 24 - - PUNCT dti-1423 305 25 pig pig NOUN dti-1423 305 26 tissues tissue NOUN dti-1423 305 27 . . PUNCT dti-1423 306 1 eur eur PROPN dti-1423 306 2 j j PROPN dti-1423 306 3 pharmacol pharmacol PROPN dti-1423 306 4 . . PUNCT dti-1423 307 1 2002 2002 NUM dti-1423 307 2 ; ; PUNCT dti-1423 307 3 437(3):179–185 437(3):179–185 NUM dti-1423 307 4 . . NOUN dti-1423 308 1 60 60 NUM dti-1423 308 2 . . PUNCT dti-1423 309 1 imamura imamura PROPN dti-1423 309 2 i i PROPN dti-1423 309 3 , , PUNCT dti-1423 309 4 watanabe watanabe PROPN dti-1423 309 5 t t PROPN dti-1423 309 6 , , PUNCT dti-1423 309 7 maeyama maeyama PROPN dti-1423 309 8 k k PROPN dti-1423 309 9 , , PUNCT dti-1423 309 10 kubota kubota PROPN dti-1423 309 11 a a X dti-1423 309 12 , , PUNCT dti-1423 309 13 okada okada PROPN dti-1423 309 14 a a PROPN dti-1423 309 15 , , PUNCT dti-1423 309 16 wada wada PROPN dti-1423 309 17 h. h. PROPN dti-1423 309 18 effect effect NOUN dti-1423 309 19 of of ADP dti-1423 309 20 food food NOUN dti-1423 309 21 intake intake NOUN dti-1423 309 22 on on ADP dti-1423 309 23 urinary urinary ADJ dti-1423 309 24 excretions excretion NOUN dti-1423 309 25 of of ADP dti-1423 309 26 histamine histamine NOUN dti-1423 309 27 , , PUNCT dti-1423 309 28 n n CCONJ dti-1423 309 29 tau tau PROPN dti-1423 309 30 - - PUNCT dti-1423 309 31 methylhistamine methylhistamine ADJ dti-1423 309 32 , , PUNCT dti-1423 309 33 imidazole imidazole NOUN dti-1423 309 34 acetic acetic ADJ dti-1423 309 35 acid acid NOUN dti-1423 309 36 and and CCONJ dti-1423 309 37 its its PRON dti-1423 309 38 conjugate(s conjugate(s NOUN dti-1423 309 39 ) ) PUNCT dti-1423 309 40 in in ADP dti-1423 309 41 humans human NOUN dti-1423 309 42 and and CCONJ dti-1423 309 43 mice mouse NOUN dti-1423 309 44 . . PUNCT dti-1423 310 1 j j PROPN dti-1423 310 2 biochem biochem PROPN dti-1423 310 3 . . PUNCT dti-1423 311 1 1984;96(6 1984;96(6 NUM dti-1423 311 2 ): ): PUNCT dti-1423 311 3 1931–1937 1931–1937 NUM dti-1423 311 4 . . PUNCT dti-1423 312 1 61 61 NUM dti-1423 312 2 . . PUNCT dti-1423 313 1 ito ito PROPN dti-1423 313 2 c c PROPN dti-1423 313 3 , , PUNCT dti-1423 313 4 onodera onodera PROPN dti-1423 313 5 k k NOUN dti-1423 313 6 , , PUNCT dti-1423 313 7 sakurai sakurai PROPN dti-1423 313 8 e e PROPN dti-1423 313 9 , , PUNCT dti-1423 313 10 sato sato PROPN dti-1423 313 11 m m PRON dti-1423 313 12 , , PUNCT dti-1423 313 13 watanabe watanabe PROPN dti-1423 313 14 t. t. PROPN dti-1423 313 15 the the DET dti-1423 313 16 effect effect NOUN dti-1423 313 17 of of ADP dti-1423 313 18 methamphetamine methamphetamine NOUN dti-1423 313 19 on on ADP dti-1423 313 20 histamine histamine NOUN dti-1423 313 21 level level NOUN dti-1423 313 22 and and CCONJ dti-1423 313 23 histidine histidine ADJ dti-1423 313 24 decarboxylase decarboxylase NOUN dti-1423 313 25 activity activity NOUN dti-1423 313 26 in in ADP dti-1423 313 27 the the DET dti-1423 313 28 rat rat NOUN dti-1423 313 29 brain brain NOUN dti-1423 313 30 . . PUNCT dti-1423 314 1 brain brain NOUN dti-1423 314 2 res re NOUN dti-1423 314 3 . . PUNCT dti-1423 315 1 1996;734(1–2):98–102 1996;734(1–2):98–102 NUM dti-1423 315 2 . . PUNCT dti-1423 316 1 62 62 NUM dti-1423 316 2 . . PUNCT dti-1423 317 1 ito ito PROPN dti-1423 317 2 c c PROPN dti-1423 317 3 , , PUNCT dti-1423 317 4 onodera onodera NOUN dti-1423 317 5 k k NOUN dti-1423 317 6 , , PUNCT dti-1423 317 7 yamatodani yamatodani PROPN dti-1423 317 8 a a PRON dti-1423 317 9 , , PUNCT dti-1423 317 10 watanabe watanabe PROPN dti-1423 317 11 t t PROPN dti-1423 317 12 , , PUNCT dti-1423 317 13 sato sato NOUN dti-1423 317 14 m. m. NOUN dti-1423 317 15 the the DET dti-1423 317 16 effect effect NOUN dti-1423 317 17 of of ADP dti-1423 317 18 methamphetamine methamphetamine NOUN dti-1423 317 19 on on ADP dti-1423 317 20 histamine histamine NOUN dti-1423 317 21 release release NOUN dti-1423 317 22 in in ADP dti-1423 317 23 the the DET dti-1423 317 24 rat rat NOUN dti-1423 317 25 hypothalamus hypothalamus PROPN dti-1423 317 26 . . PUNCT dti-1423 318 1 psychiatry psychiatry PROPN dti-1423 318 2 clin clin PROPN dti-1423 318 3 neurosci neurosci PROPN dti-1423 318 4 . . PUNCT dti-1423 319 1 1997;51(2):79–81 1997;51(2):79–81 NUM dti-1423 319 2 . . PROPN dti-1423 320 1 63 63 NUM dti-1423 320 2 . . PUNCT dti-1423 321 1 john john PROPN dti-1423 321 2 j j PROPN dti-1423 321 3 , , PUNCT dti-1423 321 4 kodama kodama PROPN dti-1423 321 5 t t PROPN dti-1423 321 6 , , PUNCT dti-1423 321 7 siegel siegel PROPN dti-1423 321 8 jm jm PROPN dti-1423 321 9 . . PROPN dti-1423 321 10 caffeine caffeine NOUN dti-1423 321 11 promotes promote VERB dti-1423 321 12 glutamate glutamate NOUN dti-1423 321 13 and and CCONJ dti-1423 321 14 histamine histamine NOUN dti-1423 321 15 release release NOUN dti-1423 321 16 in in ADP dti-1423 321 17 the the DET dti-1423 321 18 posterior posterior ADJ dti-1423 321 19 hypothalamus hypothalamus NOUN dti-1423 321 20 . . PUNCT dti-1423 322 1 am be AUX dti-1423 322 2 j j PROPN dti-1423 322 3 physiol physiol PROPN dti-1423 322 4 regul regul PROPN dti-1423 322 5 integr integr PROPN dti-1423 322 6 comp comp PROPN dti-1423 322 7 physiol physiol PROPN dti-1423 322 8 . . PUNCT dti-1423 323 1 2014;307(6):r704 2014;307(6):r704 NUM dti-1423 323 2 – – PUNCT dti-1423 323 3 r710 r710 NUM dti-1423 323 4 . . X dti-1423 324 1 64 64 NUM dti-1423 324 2 . . PUNCT dti-1423 325 1 subramanian subramanian PROPN dti-1423 325 2 n n CCONJ dti-1423 325 3 , , PUNCT dti-1423 325 4 schinzel schinzel ADJ dti-1423 325 5 w w PROPN dti-1423 325 6 , , PUNCT dti-1423 325 7 mitznegg mitznegg NOUN dti-1423 325 8 p p NOUN dti-1423 325 9 , , PUNCT dti-1423 325 10 estler estler PROPN dti-1423 325 11 cj cj NOUN dti-1423 325 12 . . PUNCT dti-1423 326 1 influence influence NOUN dti-1423 326 2 of of ADP dti-1423 326 3 ethanol ethanol NOUN dti-1423 326 4 on on ADP dti-1423 326 5 histamine histamine NOUN dti-1423 326 6 metabolism metabolism NOUN dti-1423 326 7 and and CCONJ dti-1423 326 8 release release NOUN dti-1423 326 9 in in ADP dti-1423 326 10 the the DET dti-1423 326 11 rat rat NOUN dti-1423 326 12 brain brain NOUN dti-1423 326 13 . . PUNCT dti-1423 327 1 ii ii PROPN dti-1423 327 2 . . PUNCT dti-1423 328 1 regions region NOUN dti-1423 328 2 of of ADP dti-1423 328 3 the the DET dti-1423 328 4 histaminergic histaminergic ADJ dti-1423 328 5 pathway pathway NOUN dti-1423 328 6 . . PUNCT dti-1423 329 1 pharmacology pharmacology NOUN dti-1423 329 2 . . PUNCT dti-1423 330 1 1980;20(1):42–45 1980;20(1):42–45 NUM dti-1423 330 2 . . PUNCT dti-1423 331 1 65 65 NUM dti-1423 331 2 . . PUNCT dti-1423 332 1 kitanaka kitanaka PROPN dti-1423 332 2 j j PROPN dti-1423 332 3 , , PUNCT dti-1423 332 4 kitanaka kitanaka PROPN dti-1423 332 5 n n CCONJ dti-1423 332 6 , , PUNCT dti-1423 332 7 tatsuta tatsuta PROPN dti-1423 332 8 t t PROPN dti-1423 332 9 , , PUNCT dti-1423 332 10 morita morita PROPN dti-1423 332 11 y y PROPN dti-1423 332 12 , , PUNCT dti-1423 332 13 takemura takemura VERB dti-1423 332 14 m. m. NOUN dti-1423 332 15 blockade blockade NOUN dti-1423 332 16 of of ADP dti-1423 332 17 brain brain NOUN dti-1423 332 18 histamine histamine NOUN dti-1423 332 19 metabolism metabolism NOUN dti-1423 332 20 alters alter VERB dti-1423 332 21 methamphetamine methamphetamine NOUN dti-1423 332 22 - - PUNCT dti-1423 332 23 induced induce VERB dti-1423 332 24 expression expression NOUN dti-1423 332 25 pattern pattern NOUN dti-1423 332 26 of of ADP dti-1423 332 27 stereotypy stereotypy NOUN dti-1423 332 28 in in ADP dti-1423 332 29 mice mouse NOUN dti-1423 332 30 via via ADP dti-1423 332 31 histamine histamine NOUN dti-1423 332 32 h1 h1 NOUN dti-1423 332 33 receptors receptor NOUN dti-1423 332 34 . . PUNCT dti-1423 333 1 neuroscience neuroscience NOUN dti-1423 333 2 . . PUNCT dti-1423 334 1 2007;147(3):765–777 2007;147(3):765–777 NUM dti-1423 334 2 . . PROPN dti-1423 334 3 66 66 NUM dti-1423 334 4 . . PUNCT dti-1423 335 1 muley muley PROPN dti-1423 335 2 mp mp PROPN dti-1423 335 3 , , PUNCT dti-1423 335 4 balsara balsara PROPN dti-1423 335 5 jj jj PROPN dti-1423 335 6 , , PUNCT dti-1423 335 7 chandorkar chandorkar PROPN dti-1423 335 8 ag ag PROPN dti-1423 335 9 . . PROPN dti-1423 335 10 effect effect NOUN dti-1423 335 11 of of ADP dti-1423 335 12 l l ADJ dti-1423 335 13 - - ADJ dti-1423 335 14 histidine histidine ADJ dti-1423 335 15 pretreatment pretreatment NOUN dti-1423 335 16 on on ADP dti-1423 335 17 methamphetamine methamphetamine NOUN dti-1423 335 18 induced induce VERB dti-1423 335 19 sterotyped sterotype VERB dti-1423 335 20 behaviour behaviour NOUN dti-1423 335 21 in in ADP dti-1423 335 22 rats rat NOUN dti-1423 335 23 . . PUNCT dti-1423 336 1 indian indian PROPN dti-1423 336 2 j j PROPN dti-1423 336 3 physiol physiol PROPN dti-1423 336 4 pharmacol pharmacol PROPN dti-1423 336 5 . . PUNCT dti-1423 337 1 1979;23(4):291–296 1979;23(4):291–296 NUM dti-1423 337 2 . . NOUN dti-1423 338 1 67 67 NUM dti-1423 338 2 . . PUNCT dti-1423 339 1 ito ito PROPN dti-1423 339 2 c c PROPN dti-1423 339 3 , , PUNCT dti-1423 339 4 onodera onodera PROPN dti-1423 339 5 k k NOUN dti-1423 339 6 , , PUNCT dti-1423 339 7 watanabe watanabe PROPN dti-1423 339 8 t t PROPN dti-1423 339 9 , , PUNCT dti-1423 339 10 sato sato NOUN dti-1423 339 11 m. m. NOUN dti-1423 339 12 effects effect NOUN dti-1423 339 13 of of ADP dti-1423 339 14 histamine histamine NOUN dti-1423 339 15 agents agent NOUN dti-1423 339 16 on on ADP dti-1423 339 17 methamphetamine methamphetamine NOUN dti-1423 339 18 - - PUNCT dti-1423 339 19 induced induce VERB dti-1423 339 20 stereotyped stereotype VERB dti-1423 339 21 behavior behavior NOUN dti-1423 339 22 and and CCONJ dti-1423 339 23 behavioral behavioral ADJ dti-1423 339 24 sensitization sensitization NOUN dti-1423 339 25 in in ADP dti-1423 339 26 rats rat NOUN dti-1423 339 27 . . PUNCT dti-1423 340 1 psychopharmacology psychopharmacology NOUN dti-1423 340 2 . . PUNCT dti-1423 341 1 1997;130(4):362–367 1997;130(4):362–367 PROPN dti-1423 341 2 . . PROPN dti-1423 342 1 68 68 NUM dti-1423 342 2 . . PUNCT dti-1423 343 1 zawilska zawilska PROPN dti-1423 343 2 j j PROPN dti-1423 343 3 , , PUNCT dti-1423 343 4 nowak nowak PROPN dti-1423 343 5 jz jz PROPN dti-1423 343 6 . . PROPN dti-1423 343 7 changes change NOUN dti-1423 343 8 in in ADP dti-1423 343 9 the the DET dti-1423 343 10 rat rat NOUN dti-1423 343 11 brain brain NOUN dti-1423 343 12 histamine histamine NOUN dti-1423 343 13 content content NOUN dti-1423 343 14 following follow VERB dti-1423 343 15 metoprine metoprine NOUN dti-1423 343 16 and and CCONJ dti-1423 343 17 other other ADJ dti-1423 343 18 histamine histamine NOUN dti-1423 343 19 - - PUNCT dti-1423 343 20 methyltransferase methyltransferase NOUN dti-1423 343 21 ( ( PUNCT dti-1423 343 22 hmt hmt NOUN dti-1423 343 23 ) ) PUNCT dti-1423 343 24 inhibitors inhibitor NOUN dti-1423 343 25 . . PUNCT dti-1423 344 1 pol pol PROPN dti-1423 344 2 j j PROPN dti-1423 344 3     SPACE dti-1423 344 4 pharmacol pharmacol NOUN dti-1423 344 5 pharm pharm NOUN dti-1423 344 6 . . PUNCT dti-1423 345 1 1985;37(6):821–830 1985;37(6):821–830 X dti-1423 345 2 . . NUM dti-1423 345 3 69 69 NUM dti-1423 345 4 . . PUNCT dti-1423 346 1 itoh itoh PROPN dti-1423 346 2 y y PROPN dti-1423 346 3 , , PUNCT dti-1423 346 4 oishi oishi PROPN dti-1423 346 5 r r NOUN dti-1423 346 6 , , PUNCT dti-1423 346 7 nishibori nishibori ADV dti-1423 346 8 m m PROPN dti-1423 346 9 , , PUNCT dti-1423 346 10 saeki saeki PROPN dti-1423 346 11 k. k. PROPN dti-1423 347 1 characterization characterization NOUN dti-1423 347 2 of of ADP dti-1423 347 3 histamine histamine NOUN dti-1423 347 4 release release NOUN dti-1423 347 5 from from ADP dti-1423 347 6 the the DET dti-1423 347 7 rat rat NOUN dti-1423 347 8 hypothalamus hypothalamus NOUN dti-1423 347 9 as as SCONJ dti-1423 347 10 measured measure VERB dti-1423 347 11 by by ADP dti-1423 347 12 in in ADP dti-1423 347 13 vivo vivo ADJ dti-1423 347 14 microdialysis microdialysis NOUN dti-1423 347 15 . . PUNCT dti-1423 348 1 j j PROPN dti-1423 348 2 neurochem neurochem PROPN dti-1423 348 3 . . PUNCT dti-1423 349 1 1991;56(3):769–774 1991;56(3):769–774 X dti-1423 349 2 . . PUNCT dti-1423 350 1 70 70 NUM dti-1423 350 2 . . PUNCT dti-1423 351 1 yokoyama yokoyama PROPN dti-1423 351 2 h h PROPN dti-1423 351 3 , , PUNCT dti-1423 351 4 onodera onodera PROPN dti-1423 351 5 k k NOUN dti-1423 351 6 , , PUNCT dti-1423 351 7 maeyama maeyama PROPN dti-1423 351 8 k k PROPN dti-1423 351 9 , , PUNCT dti-1423 351 10 et et PROPN dti-1423 351 11 al al PROPN dti-1423 351 12 . . PROPN dti-1423 351 13 histamine histamine NOUN dti-1423 351 14 levels level NOUN dti-1423 351 15 and and CCONJ dti-1423 351 16 clonic clonic ADJ dti-1423 351 17 convulsions convulsion NOUN dti-1423 351 18 of of ADP dti-1423 351 19 electrically electrically ADV dti-1423 351 20 - - PUNCT dti-1423 351 21 induced induce VERB dti-1423 351 22 seizure seizure NOUN dti-1423 351 23 in in ADP dti-1423 351 24 mice mouse NOUN dti-1423 351 25 : : PUNCT dti-1423 351 26 the the DET dti-1423 351 27 effects effect NOUN dti-1423 351 28 of of ADP dti-1423 351 29 alpha alpha NOUN dti-1423 351 30 - - PUNCT dti-1423 351 31 fluoromethylhistidine fluoromethylhistidine NOUN dti-1423 351 32 and and CCONJ dti-1423 351 33 metoprine metoprine NOUN dti-1423 351 34 . . PUNCT dti-1423 352 1 naunyn naunyn PROPN dti-1423 352 2 schmiedebergs schmiedebergs PROPN dti-1423 352 3 arch arch NOUN dti-1423 352 4 pharmacol pharmacol PROPN dti-1423 352 5 . . PUNCT dti-1423 353 1 1992;346(1):40–45 1992;346(1):40–45 NUM dti-1423 353 2 . . PUNCT dti-1423 354 1 71 71 NUM dti-1423 354 2 . . PUNCT dti-1423 355 1 yawata yawata PROPN dti-1423 356 1 i i PROPN dti-1423 356 2 , , PUNCT dti-1423 356 3 tanaka tanaka PROPN dti-1423 356 4 k k PROPN dti-1423 356 5 , , PUNCT dti-1423 356 6 nakagawa nakagawa PROPN dti-1423 356 7 y y PROPN dti-1423 356 8 , , PUNCT dti-1423 356 9 watanabe watanabe PROPN dti-1423 356 10 y y PROPN dti-1423 356 11 , , PUNCT dti-1423 356 12 murashima murashima NOUN dti-1423 356 13 yl yl NOUN dti-1423 356 14 , , PUNCT dti-1423 356 15 nakano nakano PROPN dti-1423 356 16 k. k. PROPN dti-1423 356 17 role role NOUN dti-1423 356 18 of of ADP dti-1423 356 19 histaminergic histaminergic ADJ dti-1423 356 20 neurons neuron NOUN dti-1423 356 21 in in ADP dti-1423 356 22 development development NOUN dti-1423 356 23 of of ADP dti-1423 356 24 epileptic epileptic ADJ dti-1423 356 25 seizures seizure NOUN dti-1423 356 26 in in ADP dti-1423 356 27 el el PROPN dti-1423 356 28 mice mouse NOUN dti-1423 356 29 . . PUNCT dti-1423 357 1 brain brain NOUN dti-1423 357 2 res re NOUN dti-1423 357 3 mol mol ADP dti-1423 357 4 brain brain NOUN dti-1423 357 5 res re NOUN dti-1423 357 6 . . PUNCT dti-1423 358 1 2004;132(1):13–17 2004;132(1):13–17 X dti-1423 358 2 . . PUNCT dti-1423 359 1 72 72 NUM dti-1423 359 2 . . PUNCT dti-1423 360 1 duch duch PROPN dti-1423 360 2 ds ds PROPN dti-1423 360 3 , , PUNCT dti-1423 360 4 bacchi bacchi PROPN dti-1423 360 5 cj cj PROPN dti-1423 360 6 , , PUNCT dti-1423 360 7 edelstein edelstein PROPN dti-1423 360 8 mp mp PROPN dti-1423 360 9 , , PUNCT dti-1423 360 10 nichol nichol PROPN dti-1423 360 11 ca can AUX dti-1423 360 12 . . PUNCT dti-1423 361 1 inhibitors inhibitor NOUN dti-1423 361 2 of of ADP dti-1423 361 3 histamine histamine NOUN dti-1423 361 4 metabolism metabolism NOUN dti-1423 361 5 in in ADP dti-1423 361 6 vitro vitro X dti-1423 361 7 and and CCONJ dti-1423 361 8 in in ADP dti-1423 361 9 vivo vivo NOUN dti-1423 361 10 . . PUNCT dti-1423 362 1 correlations correlation NOUN dti-1423 362 2 with with ADP dti-1423 362 3 antitrypanosomal antitrypanosomal ADJ dti-1423 362 4 activity activity NOUN dti-1423 362 5 . . PUNCT dti-1423 363 1 biochem biochem PROPN dti-1423 363 2 pharmacol pharmacol PROPN dti-1423 363 3 . . PUNCT dti-1423 364 1 1984;33(9):1547–1553 1984;33(9):1547–1553 NUM dti-1423 364 2 . . PUNCT dti-1423 365 1 73 73 NUM dti-1423 365 2 . . PUNCT dti-1423 366 1 duch duch PROPN dti-1423 366 2 ds ds PROPN dti-1423 366 3 , , PUNCT dti-1423 366 4 bowers bowers PROPN dti-1423 366 5 sw sw PROPN dti-1423 366 6 , , PUNCT dti-1423 366 7 nichol nichol PROPN dti-1423 366 8 ca can AUX dti-1423 366 9 . . PUNCT dti-1423 367 1 elevation elevation NOUN dti-1423 367 2 of of ADP dti-1423 367 3 brain brain NOUN dti-1423 367 4 histamine histamine NOUN dti-1423 367 5 levels level NOUN dti-1423 367 6 by by ADP dti-1423 367 7 diaminopyrimidine diaminopyrimidine NOUN dti-1423 367 8 inhibitors inhibitor NOUN dti-1423 367 9 of of ADP dti-1423 367 10 histamine histamine NOUN dti-1423 367 11 n n CCONJ dti-1423 367 12 - - PUNCT dti-1423 367 13 methyl methyl NOUN dti-1423 367 14 transferase transferase NOUN dti-1423 367 15 . . PUNCT dti-1423 368 1 biochem biochem PROPN dti-1423 368 2 pharmacol pharmacol PROPN dti-1423 368 3 . . PUNCT dti-1423 369 1 1978;27(10):1507–1509 1978;27(10):1507–1509 NOUN dti-1423 369 2 . . PUNCT dti-1423 370 1 74 74 NUM dti-1423 370 2 . . PUNCT dti-1423 371 1 beaven beaven PROPN dti-1423 371 2 ma ma PROPN dti-1423 371 3 , , PUNCT dti-1423 371 4 shaff shaff NOUN dti-1423 371 5 re re NOUN dti-1423 371 6 . . PUNCT dti-1423 371 7 inhibition inhibition NOUN dti-1423 371 8 of of ADP dti-1423 371 9 histamine histamine ADJ dti-1423 371 10 methylation methylation NOUN dti-1423 371 11 in in ADP dti-1423 371 12 vivo vivo NOUN dti-1423 371 13 by by ADP dti-1423 371 14 the the DET dti-1423 371 15 dimaprit dimaprit PROPN dti-1423 371 16 analog analog NOUN dti-1423 371 17 , , PUNCT dti-1423 371 18 skf skf PROPN dti-1423 371 19 compound compound NOUN dti-1423 371 20 91488 91488 NUM dti-1423 371 21 . . PUNCT dti-1423 372 1 agents agent NOUN dti-1423 372 2 actions action NOUN dti-1423 372 3 . . PUNCT dti-1423 373 1 1979;9(5–6):455–460 1979;9(5–6):455–460 NUM dti-1423 373 2 . . PUNCT dti-1423 374 1 75 75 NUM dti-1423 374 2 . . PUNCT dti-1423 375 1 malmberg malmberg PROPN dti-1423 375 2 - - PUNCT dti-1423 375 3 aiello aiello PROPN dti-1423 375 4 p p PROPN dti-1423 375 5 , , PUNCT dti-1423 375 6 lamberti lamberti PROPN dti-1423 375 7 c c NOUN dti-1423 375 8 , , PUNCT dti-1423 375 9 ipponi ipponi VERB dti-1423 375 10 a a PRON dti-1423 375 11 , , PUNCT dti-1423 375 12 hanninen hanninen PROPN dti-1423 375 13 j j PROPN dti-1423 375 14 , , PUNCT dti-1423 375 15 ghelardini ghelardini PROPN dti-1423 375 16 c c NOUN dti-1423 375 17 , , PUNCT dti-1423 375 18 bartolini bartolini NOUN dti-1423 375 19 a. a. NOUN dti-1423 375 20 effects effect NOUN dti-1423 375 21 of of ADP dti-1423 375 22 two two NUM dti-1423 375 23 histamine histamine NOUN dti-1423 375 24 - - PUNCT dti-1423 375 25 n n CCONJ dti-1423 375 26 - - PUNCT dti-1423 375 27 methyltransferase methyltransferase NOUN dti-1423 375 28 inhibitors inhibitor NOUN dti-1423 375 29 , , PUNCT dti-1423 375 30 skf skf PROPN dti-1423 375 31 91488 91488 NUM dti-1423 375 32 and and CCONJ dti-1423 375 33 bw bw PROPN dti-1423 375 34 301 301 NUM dti-1423 375 35 u u NOUN dti-1423 375 36 , , PUNCT dti-1423 375 37 in in ADP dti-1423 375 38 rodent rodent ADJ dti-1423 375 39 antinociception antinociception NOUN dti-1423 375 40 . . PUNCT dti-1423 376 1 naunyn naunyn PROPN dti-1423 376 2 schmiedebergs schmiedebergs PROPN dti-1423 376 3 arch arch NOUN dti-1423 376 4 pharmacol pharmacol NOUN dti-1423 376 5 . . PUNCT dti-1423 377 1 1997;355(3):354–360 1997;355(3):354–360 NUM dti-1423 377 2 . . PUNCT dti-1423 378 1 76 76 NUM dti-1423 378 2 . . PUNCT dti-1423 379 1 nichol nichol PROPN dti-1423 379 2 ca ca PROPN dti-1423 379 3 , , PUNCT dti-1423 379 4 cavallito cavallito PROPN dti-1423 379 5 jc jc PROPN dti-1423 379 6 , , PUNCT dti-1423 379 7 woolley woolley PROPN dti-1423 379 8 jl jl PROPN dti-1423 379 9 , , PUNCT dti-1423 379 10 sigel sigel PROPN dti-1423 379 11 cw cw PROPN dti-1423 379 12 . . PUNCT dti-1423 379 13 lipid lipid NOUN dti-1423 379 14 - - PUNCT dti-1423 379 15 soluble soluble ADJ dti-1423 379 16 diaminopyrimidine diaminopyrimidine NOUN dti-1423 379 17 inhibitors inhibitor NOUN dti-1423 379 18 of of ADP dti-1423 379 19 dihydrofolate dihydrofolate ADJ dti-1423 379 20 reductase reductase NOUN dti-1423 379 21 . . PUNCT dti-1423 380 1 cancer cancer NOUN dti-1423 380 2 treat treat PROPN dti-1423 380 3 rep rep PROPN dti-1423 380 4 . . PROPN dti-1423 380 5 1977;61(4):559–564 1977;61(4):559–564 NUM dti-1423 380 6 . . PUNCT dti-1423 381 1 77 77 NUM dti-1423 381 2 . . PUNCT dti-1423 382 1 lecklin lecklin PROPN dti-1423 382 2 a a NOUN dti-1423 382 3 , , PUNCT dti-1423 382 4 tuomisto tuomisto NOUN dti-1423 382 5 l l NOUN dti-1423 382 6 , , PUNCT dti-1423 382 7 macdonald macdonald PROPN dti-1423 382 8 e. e. PROPN dti-1423 382 9 metoprine metoprine PROPN dti-1423 382 10 , , PUNCT dti-1423 382 11 an an DET dti-1423 382 12 inhibitor inhibitor NOUN dti-1423 382 13 of of ADP dti-1423 382 14 histamine histamine NOUN dti-1423 382 15 n n CCONJ dti-1423 382 16 - - PUNCT dti-1423 382 17 methyltransferase methyltransferase NOUN dti-1423 382 18 but but CCONJ dti-1423 382 19 not not PART dti-1423 382 20 catechol catechol NOUN dti-1423 382 21 - - PUNCT dti-1423 382 22 o o NOUN dti-1423 382 23 - - NOUN dti-1423 382 24 methyltransferase methyltransferase NOUN dti-1423 382 25 , , PUNCT dti-1423 382 26 suppresses suppress VERB dti-1423 382 27 feeding feed VERB dti-1423 382 28 in in ADP dti-1423 382 29 sated sated ADJ dti-1423 382 30 and and CCONJ dti-1423 382 31 in in ADP dti-1423 382 32 food food NOUN dti-1423 382 33 deprived deprive VERB dti-1423 382 34 rats rat NOUN dti-1423 382 35 . . PUNCT dti-1423 383 1 methods method NOUN dti-1423 383 2 find find VERB dti-1423 383 3 exp exp NOUN dti-1423 383 4 clin clin PROPN dti-1423 383 5 pharmacol pharmacol PROPN dti-1423 383 6 . . PUNCT dti-1423 384 1 1995;17(1):47–52 1995;17(1):47–52 NUM dti-1423 384 2 . . X dti-1423 385 1 78 78 NUM dti-1423 385 2 . . PUNCT dti-1423 386 1 lecklin lecklin PROPN dti-1423 386 2 a a PROPN dti-1423 386 3 , , PUNCT dti-1423 386 4 eriksson eriksson PROPN dti-1423 386 5 l l PROPN dti-1423 386 6 , , PUNCT dti-1423 386 7 leppaluoto leppaluoto PROPN dti-1423 386 8 j j PROPN dti-1423 386 9 , , PUNCT dti-1423 386 10 tarhanen tarhanen PROPN dti-1423 386 11 j j PROPN dti-1423 386 12 , , PUNCT dti-1423 386 13 tuomisto tuomisto NOUN dti-1423 386 14 l. l. NOUN dti-1423 386 15 metoprineinduced metoprineinduce VERB dti-1423 386 16 thirst thirst NOUN dti-1423 386 17 and and CCONJ dti-1423 386 18 diuresis diuresis NOUN dti-1423 386 19 in in ADP dti-1423 386 20 wistar wistar PROPN dti-1423 386 21 rats rat NOUN dti-1423 386 22 . . PUNCT dti-1423 387 1 acta acta PROPN dti-1423 387 2 physiol physiol PROPN dti-1423 387 3 scand scand PROPN dti-1423 387 4 . . PUNCT dti-1423 388 1 1999;165(3):325–333 1999;165(3):325–333 NUM dti-1423 388 2 . . NOUN dti-1423 388 3 79 79 NUM dti-1423 388 4 . . PUNCT dti-1423 389 1 malmberg malmberg PROPN dti-1423 389 2 - - PUNCT dti-1423 389 3 aiello aiello PROPN dti-1423 389 4 p p PROPN dti-1423 389 5 , , PUNCT dti-1423 389 6 ipponi ipponi VERB dti-1423 389 7 a a PRON dti-1423 389 8 , , PUNCT dti-1423 389 9 bartolini bartolini NOUN dti-1423 389 10 a a PRON dti-1423 389 11 , , PUNCT dti-1423 389 12 schunack schunack PROPN dti-1423 389 13 w. w. PROPN dti-1423 389 14 mouse mouse PROPN dti-1423 389 15 light light ADJ dti-1423 389 16 / / SYM dti-1423 389 17 dark dark PROPN dti-1423 389 18 box box NOUN dti-1423 389 19 test test NOUN dti-1423 389 20 reveals reveal VERB dti-1423 389 21 anxiogenic anxiogenic ADJ dti-1423 389 22 - - PUNCT dti-1423 389 23 like like ADJ dti-1423 389 24 effects effect NOUN dti-1423 389 25 by by ADP dti-1423 389 26 activation activation NOUN dti-1423 389 27 of of ADP dti-1423 389 28 histamine histamine NOUN dti-1423 389 29 h1 h1 NOUN dti-1423 389 30 receptors receptor NOUN dti-1423 389 31 . . PUNCT dti-1423 390 1 pharmacol pharmacol PROPN dti-1423 390 2 biochem biochem PROPN dti-1423 390 3 behav behav NOUN dti-1423 390 4 . . PUNCT dti-1423 391 1 2002;71(1–2):313–318 2002;71(1–2):313–318 NUM dti-1423 391 2 . . PUNCT dti-1423 392 1 80 80 NUM dti-1423 392 2 . . PUNCT dti-1423 393 1 malmberg malmberg PROPN dti-1423 393 2 - - PUNCT dti-1423 393 3 aiello aiello PROPN dti-1423 393 4 p p PROPN dti-1423 393 5 , , PUNCT dti-1423 393 6 ipponi ipponi VERB dti-1423 393 7 a a PRON dti-1423 393 8 , , PUNCT dti-1423 393 9 bartolini bartolini NOUN dti-1423 393 10 a a PRON dti-1423 393 11 , , PUNCT dti-1423 393 12 schunack schunack PROPN dti-1423 393 13 w. w. PROPN dti-1423 393 14 antiamnesic antiamnesic ADJ dti-1423 393 15 effect effect NOUN dti-1423 393 16 of of ADP dti-1423 393 17 metoprine metoprine NOUN dti-1423 393 18 and and CCONJ dti-1423 393 19 of of ADP dti-1423 393 20 selective selective ADJ dti-1423 393 21 histamine histamine NOUN dti-1423 393 22 h(1 h(1 NOUN dti-1423 393 23 ) ) PUNCT dti-1423 393 24 receptor receptor NOUN dti-1423 393 25 agonists agonist NOUN dti-1423 393 26 in in ADP dti-1423 393 27 a a DET dti-1423 393 28 modified modify VERB dti-1423 393 29 mouse mouse NOUN dti-1423 393 30 passive passive ADJ dti-1423 393 31 avoidance avoidance NOUN dti-1423 393 32 test test NOUN dti-1423 393 33 . . PUNCT dti-1423 394 1 neurosci neurosci PROPN dti-1423 394 2 lett lett PROPN dti-1423 394 3 . . PUNCT dti-1423 395 1 2000;288(1):1–4 2000;288(1):1–4 NOUN dti-1423 395 2 . . PUNCT dti-1423 396 1 81 81 NUM dti-1423 396 2 . . PUNCT dti-1423 397 1 itoh itoh PROPN dti-1423 397 2 y y PROPN dti-1423 397 3 , , PUNCT dti-1423 397 4 nishibori nishibori ADV dti-1423 397 5 m m PROPN dti-1423 397 6 , , PUNCT dti-1423 397 7 oishi oishi PROPN dti-1423 397 8 r r PROPN dti-1423 397 9 , , PUNCT dti-1423 397 10 saeki saeki PROPN dti-1423 397 11 k. k. PROPN dti-1423 398 1 neuronal neuronal ADJ dti-1423 398 2 histamine histamine NOUN dti-1423 398 3 inhibits inhibit VERB dti-1423 398 4 methamphetamine methamphetamine NOUN dti-1423 398 5 - - PUNCT dti-1423 398 6 induced induce VERB dti-1423 398 7 locomotor locomotor NOUN dti-1423 398 8 hyperactivity hyperactivity NOUN dti-1423 398 9 in in ADP dti-1423 398 10 mice mouse NOUN dti-1423 398 11 . . PUNCT dti-1423 399 1 neurosci neurosci PROPN dti-1423 399 2 lett lett PROPN dti-1423 399 3 . . PROPN dti-1423 399 4 1984 1984 NUM dti-1423 399 5 ; ; PUNCT dti-1423 399 6 48(3):305–309 48(3):305–309 NOUN dti-1423 399 7 . . PUNCT dti-1423 400 1 82 82 NUM dti-1423 400 2 . . PUNCT dti-1423 401 1 kitanaka kitanaka PROPN dti-1423 401 2 j j PROPN dti-1423 401 3 , , PUNCT dti-1423 401 4 kitanaka kitanaka PROPN dti-1423 401 5 n n CCONJ dti-1423 401 6 , , PUNCT dti-1423 401 7 tatsuta tatsuta PROPN dti-1423 401 8 t t PROPN dti-1423 401 9 , , PUNCT dti-1423 401 10 et et PROPN dti-1423 401 11 al al PROPN dti-1423 401 12 . . PUNCT dti-1423 401 13 pretreatment pretreatment NOUN dti-1423 401 14 with with ADP dti-1423 401 15 l l NOUN dti-1423 401 16 - - NOUN dti-1423 401 17 histidine histidine NOUN dti-1423 401 18 produces produce VERB dti-1423 401 19 a a DET dti-1423 401 20 shift shift NOUN dti-1423 401 21 from from ADP dti-1423 401 22 methamphetamine methamphetamine NOUN dti-1423 401 23 - - PUNCT dti-1423 401 24 induced induce VERB dti-1423 401 25 stereotypical stereotypical ADJ dti-1423 401 26 biting bite VERB dti-1423 401 27 to to ADP dti-1423 401 28 persistent persistent ADJ dti-1423 401 29 locomotion locomotion NOUN dti-1423 401 30 in in ADP dti-1423 401 31 mice mouse NOUN dti-1423 401 32 . . PUNCT dti-1423 402 1 pharmacol pharmacol PROPN dti-1423 402 2 biochem biochem PROPN dti-1423 402 3 behav behav NOUN dti-1423 402 4 . . PUNCT dti-1423 403 1 2010;94(3):464–470 2010;94(3):464–470 NUM dti-1423 403 2 . . X dti-1423 403 3 83 83 NUM dti-1423 403 4 . . PUNCT dti-1423 404 1 iwabuchi iwabuchi PROPN dti-1423 404 2 k k PROPN dti-1423 404 3 , , PUNCT dti-1423 404 4 kubota kubota PROPN dti-1423 404 5 y y PROPN dti-1423 404 6 , , PUNCT dti-1423 404 7 ito ito PROPN dti-1423 404 8 c c PROPN dti-1423 404 9 , , PUNCT dti-1423 404 10 watanabe watanabe PROPN dti-1423 404 11 t t PROPN dti-1423 404 12 , , PUNCT dti-1423 404 13 yanai yanai PROPN dti-1423 404 14 k. k. PROPN dti-1423 404 15 methamphetamine methamphetamine PROPN dti-1423 404 16 and and CCONJ dti-1423 404 17 brain brain NOUN dti-1423 404 18 histamine histamine NOUN dti-1423 404 19 : : PUNCT dti-1423 404 20 a a DET dti-1423 404 21 study study NOUN dti-1423 404 22 using use VERB dti-1423 404 23 histamine histamine NOUN dti-1423 404 24 - - PUNCT dti-1423 404 25 related relate VERB dti-1423 404 26 gene gene NOUN dti-1423 404 27 knockout knockout NOUN dti-1423 404 28 mice mouse NOUN dti-1423 404 29 . . PUNCT dti-1423 405 1 ann ann PROPN dti-1423 405 2 n n PROPN dti-1423 405 3 y y PROPN dti-1423 405 4 acad acad PROPN dti-1423 405 5 sci sci PROPN dti-1423 405 6 . . PUNCT dti-1423 405 7 2004;1025:129–134 2004;1025:129–134 NUM dti-1423 405 8 . . PUNCT dti-1423 405 9 84 84 NUM dti-1423 405 10 . . PUNCT dti-1423 406 1 munzar munzar PROPN dti-1423 406 2 p p NOUN dti-1423 406 3 , , PUNCT dti-1423 406 4 nosal nosal ADJ dti-1423 406 5 r r PROPN dti-1423 406 6 , , PUNCT dti-1423 406 7 goldberg goldberg PROPN dti-1423 406 8 sr sr PROPN dti-1423 406 9 . . PUNCT dti-1423 407 1 potentiation potentiation NOUN dti-1423 407 2 of of ADP dti-1423 407 3 the the DET dti-1423 407 4 discriminative discriminative NOUN dti-1423 407 5 - - PUNCT dti-1423 407 6 stimulus stimulus ADJ dti-1423 407 7 effects effect NOUN dti-1423 407 8 of of ADP dti-1423 407 9 methamphetamine methamphetamine NOUN dti-1423 407 10 by by ADP dti-1423 407 11 the the DET dti-1423 407 12 histamine histamine NOUN dti-1423 407 13 h3 h3 NOUN dti-1423 407 14 receptor receptor NOUN dti-1423 407 15 antagonist antagonist NOUN dti-1423 407 16 thioperamide thioperamide ADV dti-1423 407 17 in in ADP dti-1423 407 18 rats rat NOUN dti-1423 407 19 . . PUNCT dti-1423 408 1 eur eur PROPN dti-1423 408 2 j j PROPN dti-1423 408 3 pharmacol pharmacol PROPN dti-1423 408 4 . . PUNCT dti-1423 409 1 1998;363(2–3):93–101 1998;363(2–3):93–101 NUM dti-1423 409 2 . . NOUN dti-1423 409 3 85 85 NUM dti-1423 409 4 . . PUNCT dti-1423 410 1 munzar munzar PROPN dti-1423 410 2 p p PROPN dti-1423 410 3 , , PUNCT dti-1423 410 4 tanda tanda PROPN dti-1423 410 5 g g PROPN dti-1423 410 6 , , PUNCT dti-1423 410 7 justinova justinova PROPN dti-1423 410 8 z z PROPN dti-1423 410 9 , , PUNCT dti-1423 410 10 goldberg goldberg PROPN dti-1423 410 11 sr sr PROPN dti-1423 410 12 . . PUNCT dti-1423 411 1 histamine histamine NOUN dti-1423 411 2 h3 h3 NOUN dti-1423 411 3 receptor receptor NOUN dti-1423 411 4 antagonists antagonist NOUN dti-1423 411 5 potentiate potentiate VERB dti-1423 411 6 methamphetamine methamphetamine NOUN dti-1423 411 7 self self NOUN dti-1423 411 8 - - PUNCT dti-1423 411 9 administration administration NOUN dti-1423 411 10 and and CCONJ dti-1423 411 11 methamphetamine methamphetamine NOUN dti-1423 411 12 induced induce VERB dti-1423 411 13 accumbal accumbal ADJ dti-1423 411 14 dopamine dopamine NOUN dti-1423 411 15 release release NOUN dti-1423 411 16 . . PUNCT dti-1423 412 1 neuropsychopharmacology neuropsychopharmacology NOUN dti-1423 412 2 . . PUNCT dti-1423 413 1 2004;29(4 2004;29(4 NUM dti-1423 413 2 ): ): PUNCT dti-1423 414 1 705–717 705–717 NUM dti-1423 414 2 . . PUNCT dti-1423 415 1 86 86 NUM dti-1423 415 2 . . PUNCT dti-1423 416 1 kitanaka kitanaka PROPN dti-1423 416 2 j j PROPN dti-1423 416 3 , , PUNCT dti-1423 416 4 kitanaka kitanaka PROPN dti-1423 416 5 n n CCONJ dti-1423 416 6 , , PUNCT dti-1423 416 7 hall hall PROPN dti-1423 416 8 fs fs PROPN dti-1423 416 9 , , PUNCT dti-1423 416 10 et et PROPN dti-1423 416 11 al al PROPN dti-1423 416 12 . . PUNCT dti-1423 417 1 histamine histamine NOUN dti-1423 417 2 h3 h3 NOUN dti-1423 417 3 receptor receptor NOUN dti-1423 417 4 agonists agonist NOUN dti-1423 417 5 decrease decrease VERB dti-1423 417 6 hypothalamic hypothalamic ADJ dti-1423 417 7 histamine histamine NOUN dti-1423 417 8 levels level NOUN dti-1423 417 9 and and CCONJ dti-1423 417 10 increase increase VERB dti-1423 417 11 stereotypical stereotypical ADJ dti-1423 417 12 biting bite VERB dti-1423 417 13 in in ADP dti-1423 417 14 mice mouse NOUN dti-1423 417 15 challenged challenge VERB dti-1423 417 16 with with ADP dti-1423 417 17 methamphetamine methamphetamine NOUN dti-1423 417 18 . . PUNCT dti-1423 418 1 neurochem neurochem PROPN dti-1423 418 2 res re NOUN dti-1423 418 3 . . PUNCT dti-1423 419 1 2011;36(10):1824–1833 2011;36(10):1824–1833 NUM dti-1423 419 2 . . PUNCT dti-1423 420 1 87 87 NUM dti-1423 420 2 . . PUNCT dti-1423 421 1 kitanaka kitanaka PROPN dti-1423 421 2 j j PROPN dti-1423 421 3 , , PUNCT dti-1423 421 4 kitanaka kitanaka PROPN dti-1423 421 5 n n NUM dti-1423 421 6 , , PUNCT dti-1423 421 7 takemura takemura NOUN dti-1423 421 8 m. m. NOUN dti-1423 421 9 [ [ PUNCT dti-1423 421 10 methamphetamine methamphetamine NOUN dti-1423 421 11 - - PUNCT dti-1423 421 12 induced induce VERB dti-1423 421 13 brain brain NOUN dti-1423 421 14 pathology pathology NOUN dti-1423 421 15 and and CCONJ dti-1423 421 16 central central ADJ dti-1423 421 17 histaminergic histaminergic ADJ dti-1423 421 18 system system NOUN dti-1423 421 19 ] ] PUNCT dti-1423 421 20 ( ( PUNCT dti-1423 421 21 in in ADP dti-1423 421 22 japanese japanese PROPN dti-1423 421 23 ) ) PUNCT dti-1423 421 24 . . PUNCT dti-1423 422 1 brain21 brain21 PROPN dti-1423 422 2 ( ( PUNCT dti-1423 422 3 nou21 nou21 PROPN dti-1423 422 4 ) ) PUNCT dti-1423 422 5 . . PUNCT dti-1423 423 1 2015;18(2):83–88 2015;18(2):83–88 NUM dti-1423 423 2 . . NOUN dti-1423 423 3 88 88 NUM dti-1423 423 4 . . PUNCT dti-1423 424 1 fox fox PROPN dti-1423 424 2 gb gb PROPN dti-1423 424 3 , , PUNCT dti-1423 424 4 esbenshade esbenshade VERB dti-1423 424 5 ta ta PROPN dti-1423 424 6 , , PUNCT dti-1423 424 7 pan pan PROPN dti-1423 424 8 jb jb PROPN dti-1423 424 9 , , PUNCT dti-1423 424 10 et et PROPN dti-1423 424 11 al al PROPN dti-1423 424 12 . . PUNCT dti-1423 425 1 pharmacological pharmacological ADJ dti-1423 425 2 properties property NOUN dti-1423 425 3 of of ADP dti-1423 425 4 abt-239 abt-239 NOUN dti-1423 425 5 [ [ PUNCT dti-1423 425 6 4-(2-{2-[(2r)-2 4-(2-{2-[(2r)-2 NUM dti-1423 425 7 - - PUNCT dti-1423 425 8 methylpyrrolidinyl]ethyl}-benzofuran-5 methylpyrrolidinyl]ethyl}-benzofuran-5 NOUN dti-1423 425 9 - - PUNCT dti-1423 425 10 yl)benzonitrile yl)benzonitrile NOUN dti-1423 425 11 ] ] PRON dti-1423 425 12 : : PUNCT dti-1423 425 13 ii ii X dti-1423 425 14 . . PUNCT dti-1423 425 15 neurophysiological neurophysiological ADJ dti-1423 425 16 characterization characterization NOUN dti-1423 425 17 and and CCONJ dti-1423 425 18 broad broad ADJ dti-1423 425 19 preclinical preclinical ADJ dti-1423 425 20 efficacy efficacy NOUN dti-1423 425 21 in in ADP dti-1423 425 22 cognition cognition NOUN dti-1423 425 23 and and CCONJ dti-1423 425 24 schizophrenia schizophrenia NOUN dti-1423 425 25 of of ADP dti-1423 425 26 a a DET dti-1423 425 27 potent potent ADJ dti-1423 425 28 and and CCONJ dti-1423 425 29 selective selective ADJ dti-1423 425 30 histamine histamine NOUN dti-1423 425 31 h3 h3 NOUN dti-1423 425 32 receptor receptor NOUN dti-1423 425 33 antagonist antagonist NOUN dti-1423 425 34 . . PUNCT dti-1423 426 1 j j NOUN dti-1423 426 2     SPACE dti-1423 426 3 pharmacol pharmacol PROPN dti-1423 426 4 exp exp NOUN dti-1423 426 5 ther ther ADV dti-1423 426 6 . . PUNCT dti-1423 427 1 2005;313(1):176–190 2005;313(1):176–190 NUM dti-1423 427 2 . . PUNCT dti-1423 427 3 89 89 NUM dti-1423 427 4 . . PUNCT dti-1423 428 1 sakai sakai PROPN dti-1423 428 2 n n PROPN dti-1423 428 3 , , PUNCT dti-1423 428 4 onodera onodera NOUN dti-1423 428 5 k k NOUN dti-1423 428 6 , , PUNCT dti-1423 428 7 maeyama maeyama PROPN dti-1423 428 8 k k NOUN dti-1423 428 9 , , PUNCT dti-1423 428 10 yanai yanai PROPN dti-1423 428 11 k k PROPN dti-1423 428 12 , , PUNCT dti-1423 428 13 watanabe watanabe PROPN dti-1423 428 14 t. t. PROPN dti-1423 428 15 effects effect NOUN dti-1423 428 16 of of ADP dti-1423 428 17 ( ( PUNCT dti-1423 428 18 s)-alphafluoromethylhistidine s)-alphafluoromethylhistidine X dti-1423 428 19 and and CCONJ dti-1423 428 20 metoprine metoprine NOUN dti-1423 428 21 on on ADP dti-1423 428 22 locomotor locomotor NOUN dti-1423 428 23 activity activity NOUN dti-1423 428 24 and and CCONJ dti-1423 428 25 brain brain NOUN dti-1423 428 26 histamine histamine NOUN dti-1423 428 27 content content NOUN dti-1423 428 28 in in ADP dti-1423 428 29 mice mouse NOUN dti-1423 428 30 . . PUNCT dti-1423 429 1 life life PROPN dti-1423 429 2 sci sci PROPN dti-1423 429 3 . . PUNCT dti-1423 429 4 1992;51(6):397–405 1992;51(6):397–405 PROPN dti-1423 429 5 . . PUNCT dti-1423 429 6 90 90 NUM dti-1423 429 7 . . PUNCT dti-1423 430 1 samotaeva samotaeva PROPN dti-1423 430 2 is be AUX dti-1423 430 3 , , PUNCT dti-1423 430 4 birioukova birioukova PROPN dti-1423 430 5 lm lm PROPN dti-1423 430 6 , , PUNCT dti-1423 430 7 midzyanovskaya midzyanovskaya NOUN dti-1423 430 8 is be AUX dti-1423 430 9 , , PUNCT dti-1423 430 10 kuznetsova kuznetsova PROPN dti-1423 430 11 gd gd PROPN dti-1423 430 12 , , PUNCT dti-1423 430 13 bazyan bazyan VERB dti-1423 430 14 as as ADP dti-1423 430 15 , , PUNCT dti-1423 430 16 tuomisto tuomisto NOUN dti-1423 430 17 l. l. PROPN dti-1423 430 18 metoprine metoprine PROPN dti-1423 430 19 induced induce VERB dti-1423 430 20 behavioral behavioral ADJ dti-1423 430 21 modifications modification NOUN dti-1423 430 22 and and CCONJ dti-1423 430 23 brain brain NOUN dti-1423 430 24 regional regional ADJ dti-1423 430 25 histamine histamine NOUN dti-1423 430 26 increase increase NOUN dti-1423 430 27 in in ADP dti-1423 430 28 wag wag NOUN dti-1423 430 29 / / SYM dti-1423 430 30 rij rij X dti-1423 430 31 and and CCONJ dti-1423 430 32 wistar wistar PROPN dti-1423 430 33 rats rat NOUN dti-1423 430 34 . . PUNCT dti-1423 431 1 epilepsy epilepsy NOUN dti-1423 431 2 res re NOUN dti-1423 431 3 . . PUNCT dti-1423 432 1 2012;101(1–2):148–156 2012;101(1–2):148–156 NUM dti-1423 432 2 . . PUNCT dti-1423 433 1 91 91 NUM dti-1423 433 2 . . PUNCT dti-1423 434 1 bristow bristow PROPN dti-1423 434 2 lj lj PROPN dti-1423 434 3 , , PUNCT dti-1423 434 4 bennett bennett PROPN dti-1423 434 5 gw gw PROPN dti-1423 434 6 . . PUNCT dti-1423 434 7 biphasic biphasic ADJ dti-1423 434 8 effects effect NOUN dti-1423 434 9 of of ADP dti-1423 434 10 intra intra ADJ dti-1423 434 11 - - ADJ dti-1423 434 12 accumbens accumbens ADJ dti-1423 434 13 histamine histamine NOUN dti-1423 434 14 administration administration NOUN dti-1423 434 15 on on ADP dti-1423 434 16 spontaneous spontaneous ADJ dti-1423 434 17 motor motor NOUN dti-1423 434 18 activity activity NOUN dti-1423 434 19 in in ADP dti-1423 434 20 the the DET dti-1423 434 21 rat rat NOUN dti-1423 434 22 ; ; PUNCT dti-1423 434 23 a a DET dti-1423 434 24 role role NOUN dti-1423 434 25 for for ADP dti-1423 434 26 central central ADJ dti-1423 434 27 histamine histamine NOUN dti-1423 434 28 receptors receptor NOUN dti-1423 434 29 . . PUNCT dti-1423 435 1 br br PROPN dti-1423 435 2 j j PROPN dti-1423 435 3 pharmacol pharmacol PROPN dti-1423 435 4 . . PUNCT dti-1423 436 1 1988;95(4):1292–1302 1988;95(4):1292–1302 NUM dti-1423 436 2 . . PUNCT dti-1423 437 1 http://www.la-press.com http://www.la-press.com X dti-1423 438 1 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1423 438 2 treatment treatment NOUN dti-1423 438 3 for for ADP dti-1423 438 4 methamphetamine methamphetamine NOUN dti-1423 438 5 overdose overdose ADP dti-1423 438 6 7drug 7drug NUM dti-1423 438 7 target target NOUN dti-1423 438 8 insights insight NOUN dti-1423 438 9 2016:10 2016:10 NUM dti-1423 438 10 92 92 NUM dti-1423 438 11 . . PUNCT dti-1423 439 1 chiavegatto chiavegatto PROPN dti-1423 439 2 s s PROPN dti-1423 439 3 , , PUNCT dti-1423 439 4 nasello nasello PROPN dti-1423 439 5 ag ag PROPN dti-1423 439 6 , , PUNCT dti-1423 439 7 bernardi bernardi PROPN dti-1423 439 8 mm mm PROPN dti-1423 439 9 . . PUNCT dti-1423 439 10 histamine histamine NOUN dti-1423 439 11 and and CCONJ dti-1423 439 12 spontaneous spontaneous ADJ dti-1423 439 13 motor motor NOUN dti-1423 439 14 activity activity NOUN dti-1423 439 15 : : PUNCT dti-1423 439 16 biphasic biphasic ADJ dti-1423 439 17 changes change NOUN dti-1423 439 18 , , PUNCT dti-1423 439 19 receptors receptor NOUN dti-1423 439 20 involved involve VERB dti-1423 439 21 and and CCONJ dti-1423 439 22 participation participation NOUN dti-1423 439 23 of of ADP dti-1423 439 24 the the DET dti-1423 439 25 striatal striatal ADJ dti-1423 439 26 dopamine dopamine NOUN dti-1423 439 27 system system NOUN dti-1423 439 28 . . PUNCT dti-1423 440 1 life life PROPN dti-1423 440 2 sci sci PROPN dti-1423 440 3 . . PUNCT dti-1423 440 4 1998;62(20):1875–1888 1998;62(20):1875–1888 NUM dti-1423 440 5 . . PUNCT dti-1423 441 1 93 93 NUM dti-1423 441 2 . . PUNCT dti-1423 441 3 tuomisto tuomisto NOUN dti-1423 441 4 l l NOUN dti-1423 441 5 , , PUNCT dti-1423 441 6 tacke tacke PROPN dti-1423 441 7 u u NOUN dti-1423 441 8 , , PUNCT dti-1423 441 9 willman willman PROPN dti-1423 441 10 a. a. NOUN dti-1423 441 11 inhibition inhibition NOUN dti-1423 441 12 of of ADP dti-1423 441 13 sound sound ADV dti-1423 441 14 - - PUNCT dti-1423 441 15 induced induce VERB dti-1423 441 16 convulsions convulsion NOUN dti-1423 441 17 by by ADP dti-1423 441 18 metoprine metoprine NOUN dti-1423 441 19 in in ADP dti-1423 441 20 the the DET dti-1423 441 21 audiogenic audiogenic NOUN dti-1423 441 22 seizure seizure VERB dti-1423 441 23 susceptible susceptible ADJ dti-1423 441 24 rat rat NOUN dti-1423 441 25 . . PUNCT dti-1423 441 26 agents agent NOUN dti-1423 441 27 actions action NOUN dti-1423 441 28 . . PUNCT dti-1423 442 1 1987;20(3–4 1987;20(3–4 NUM dti-1423 442 2 ): ): PUNCT dti-1423 442 3 252–254 252–254 NUM dti-1423 442 4 . . PUNCT dti-1423 443 1 94 94 NUM dti-1423 443 2 . . PUNCT dti-1423 444 1 kakinoki kakinoki PROPN dti-1423 444 2 h h PROPN dti-1423 444 3 , , PUNCT dti-1423 444 4 ishizawa ishizawa PROPN dti-1423 444 5 k k NOUN dti-1423 444 6 , , PUNCT dti-1423 444 7 fukunaga fukunaga PROPN dti-1423 444 8 m m PROPN dti-1423 444 9 , , PUNCT dti-1423 444 10 fujii fujii PROPN dti-1423 444 11 y y PROPN dti-1423 444 12 , , PUNCT dti-1423 444 13 kamei kamei PROPN dti-1423 444 14 c. c. PROPN dti-1423 445 1 the the DET dti-1423 445 2 effects effect NOUN dti-1423 445 3 of of ADP dti-1423 445 4 histamine histamine NOUN dti-1423 445 5 h3 h3 NOUN dti-1423 445 6 - - PUNCT dti-1423 445 7 receptor receptor NOUN dti-1423 445 8 antagonists antagonist NOUN dti-1423 445 9 on on ADP dti-1423 445 10 amygdaloid amygdaloid ADJ dti-1423 445 11 kindled kindle VERB dti-1423 445 12 seizures seizure NOUN dti-1423 445 13 in in ADP dti-1423 445 14 rats rat NOUN dti-1423 445 15 . . PUNCT dti-1423 446 1 brain brain NOUN dti-1423 446 2 res re NOUN dti-1423 446 3 bull bull NOUN dti-1423 446 4 . . PUNCT dti-1423 447 1 1998;46(5):461–465 1998;46(5):461–465 NOUN dti-1423 447 2 . . PUNCT dti-1423 448 1 95 95 NUM dti-1423 448 2 . . PUNCT dti-1423 449 1 castellan castellan PROPN dti-1423 449 2 baldan baldan PROPN dti-1423 449 3 l l PROPN dti-1423 449 4 , , PUNCT dti-1423 449 5 williams williams PROPN dti-1423 449 6 ka ka PROPN dti-1423 449 7 , , PUNCT dti-1423 449 8 gallezot gallezot PROPN dti-1423 449 9 jd jd PROPN dti-1423 449 10 , , PUNCT dti-1423 449 11 et et PROPN dti-1423 449 12 al al PROPN dti-1423 449 13 . . PROPN dti-1423 449 14 histidine histidine ADJ dti-1423 449 15 decarboxylase decarboxylase NOUN dti-1423 449 16 deficiency deficiency NOUN dti-1423 449 17 causes cause VERB dti-1423 449 18 tourette tourette NOUN dti-1423 449 19 syndrome syndrome NOUN dti-1423 449 20 : : PUNCT dti-1423 449 21 parallel parallel ADJ dti-1423 449 22 findings finding NOUN dti-1423 449 23 in in ADP dti-1423 449 24 humans human NOUN dti-1423 449 25 and and CCONJ dti-1423 449 26 mice mouse NOUN dti-1423 449 27 . . PUNCT dti-1423 450 1 neuron neuron PROPN dti-1423 450 2 . . PUNCT dti-1423 451 1 2014;81(1):77–90 2014;81(1):77–90 NUM dti-1423 451 2 . . PUNCT dti-1423 452 1 96 96 NUM dti-1423 452 2 . . PUNCT dti-1423 453 1 arrang arrang PROPN dti-1423 453 2 jm jm PROPN dti-1423 453 3 , , PUNCT dti-1423 453 4 garbarg garbarg NOUN dti-1423 453 5 m m PROPN dti-1423 453 6 , , PUNCT dti-1423 453 7 schwartz schwartz PROPN dti-1423 453 8 jc jc PROPN dti-1423 453 9 . . PROPN dti-1423 453 10 autoregulation autoregulation NOUN dti-1423 453 11 of of ADP dti-1423 453 12 histamine histamine NOUN dti-1423 453 13 release release NOUN dti-1423 453 14 in in ADP dti-1423 453 15 brain brain NOUN dti-1423 453 16 by by ADP dti-1423 453 17 presynaptic presynaptic ADJ dti-1423 453 18 h3 h3 NOUN dti-1423 453 19 - - PUNCT dti-1423 453 20 receptors receptor NOUN dti-1423 453 21 . . PUNCT dti-1423 454 1 neuroscience neuroscience NOUN dti-1423 454 2 . . PUNCT dti-1423 455 1 1985;15(2):553–562 1985;15(2):553–562 NUM dti-1423 455 2 . . PROPN dti-1423 455 3 97 97 NUM dti-1423 455 4 . . PUNCT dti-1423 456 1 ishizuka ishizuka PROPN dti-1423 456 2 t t PROPN dti-1423 456 3 , , PUNCT dti-1423 456 4 sakamoto sakamoto PROPN dti-1423 456 5 y y PROPN dti-1423 456 6 , , PUNCT dti-1423 456 7 sakurai sakurai PROPN dti-1423 456 8 t t PROPN dti-1423 456 9 , , PUNCT dti-1423 456 10 yamatodani yamatodani PROPN dti-1423 456 11 a. a. PROPN dti-1423 456 12 modafinil modafinil PROPN dti-1423 456 13 increases increase VERB dti-1423 456 14 histamine histamine NOUN dti-1423 456 15 release release NOUN dti-1423 456 16 in in ADP dti-1423 456 17 the the DET dti-1423 456 18 anterior anterior ADJ dti-1423 456 19 hypothalamus hypothalamus NOUN dti-1423 456 20 of of ADP dti-1423 456 21 rats rat NOUN dti-1423 456 22 . . PUNCT dti-1423 457 1 neurosci neurosci PROPN dti-1423 457 2 lett lett PROPN dti-1423 457 3 . . PUNCT dti-1423 458 1 2003;339(2):143–146 2003;339(2):143–146 NUM dti-1423 458 2 . . PUNCT dti-1423 458 3 http://www.la-press.com http://www.la-press.com X dti-1423 458 4 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN