id sid tid token lemma pos dti-1425 1 1 9drug 9drug NUM dti-1425 1 2 target target NOUN dti-1425 1 3 insights insight NOUN dti-1425 1 4 2016:10(s1 2016:10(s1 NUM dti-1425 1 5 ) ) PUNCT dti-1425 1 6 gentamicin gentamicin NOUN dti-1425 1 7 - - PUNCT dti-1425 1 8 impregnated impregnate VERB dti-1425 1 9 collagen collagen NOUN dti-1425 1 10 sponge sponge NOUN dti-1425 1 11 : : PUNCT dti-1425 1 12 effectiveness effectiveness NOUN dti-1425 1 13 in in ADP dti-1425 1 14 preventing prevent VERB dti-1425 1 15 sternal sternal ADJ dti-1425 1 16 wound wound NOUN dti-1425 1 17 infection infection NOUN dti-1425 1 18 in in ADP dti-1425 1 19 high high ADJ dti-1425 1 20 - - PUNCT dti-1425 1 21 risk risk NOUN dti-1425 1 22 cardiac cardiac ADJ dti-1425 1 23 surgery surgery NOUN dti-1425 1 24 supplementary supplementary ADJ dti-1425 1 25 issue issue NOUN dti-1425 1 26 : : PUNCT dti-1425 1 27 current current ADJ dti-1425 1 28 developments development NOUN dti-1425 1 29 in in ADP dti-1425 1 30 drug drug NOUN dti-1425 1 31 eluting eluting NOUN dti-1425 1 32 devices device NOUN dti-1425 1 33 filippo filippo PROPN dti-1425 1 34 rapetto1 rapetto1 PROPN dti-1425 1 35 , , PUNCT dti-1425 1 36 vito vito PROPN dti-1425 1 37 d. d. PROPN dti-1425 1 38 bruno1 bruno1 PROPN dti-1425 1 39 , , PUNCT dti-1425 1 40 gustavo gustavo PROPN dti-1425 1 41 guida1 guida1 PROPN dti-1425 1 42 , , PUNCT dti-1425 1 43 roberto roberto PROPN dti-1425 1 44 marsico1 marsico1 PROPN dti-1425 1 45 , , PUNCT dti-1425 1 46 pierpaolo pierpaolo ADJ dti-1425 1 47 chivasso1 chivasso1 PROPN dti-1425 1 48 and and CCONJ dti-1425 1 49 carlo carlo PROPN dti-1425 1 50 zebele2 zebele2 PROPN dti-1425 1 51 1department 1department NUM dti-1425 1 52 of of ADP dti-1425 1 53 cardiac cardiac ADJ dti-1425 1 54 surgery surgery NOUN dti-1425 1 55 , , PUNCT dti-1425 1 56 bristol bristol PROPN dti-1425 1 57 heart heart PROPN dti-1425 1 58 institute institute PROPN dti-1425 1 59 , , PUNCT dti-1425 1 60 bristol bristol PROPN dti-1425 1 61 , , PUNCT dti-1425 1 62 uk uk PROPN dti-1425 1 63 . . PROPN dti-1425 1 64 2department 2department NUM dti-1425 1 65 of of ADP dti-1425 1 66 cardiac cardiac ADJ dti-1425 1 67 surgery surgery NOUN dti-1425 1 68 , , PUNCT dti-1425 1 69 citta citta NOUN dti-1425 1 70 ’ ' PUNCT dti-1425 1 71 di di NOUN dti-1425 1 72 lecce lecce PROPN dti-1425 1 73 hospital hospital PROPN dti-1425 1 74 , , PUNCT dti-1425 1 75 lecce lecce PROPN dti-1425 1 76 , , PUNCT dti-1425 1 77 italy italy PROPN dti-1425 1 78 . . PUNCT dti-1425 2 1 abstr abstr PROPN dti-1425 2 2 act act PROPN dti-1425 2 3 : : PUNCT dti-1425 2 4 sternal sternal ADJ dti-1425 2 5 wound wound NOUN dti-1425 2 6 infections infection NOUN dti-1425 2 7 represent represent VERB dti-1425 2 8 one one NUM dti-1425 2 9 of of ADP dti-1425 2 10 the the DET dti-1425 2 11 most most ADV dti-1425 2 12 frequent frequent ADJ dti-1425 2 13 complications complication NOUN dti-1425 2 14 after after ADP dti-1425 2 15 cardiac cardiac ADJ dti-1425 2 16 surgery surgery NOUN dti-1425 2 17 and and CCONJ dti-1425 2 18 are be AUX dti-1425 2 19 associated associate VERB dti-1425 2 20 with with ADP dti-1425 2 21 high high ADJ dti-1425 2 22 postoperative postoperative ADJ dti-1425 2 23 mortality mortality NOUN dti-1425 2 24 . . PUNCT dti-1425 3 1 several several ADJ dti-1425 3 2 preventive preventive ADJ dti-1425 3 3 methods method NOUN dti-1425 3 4 have have AUX dti-1425 3 5 been be AUX dti-1425 3 6 introduced introduce VERB dti-1425 3 7 , , PUNCT dti-1425 3 8 and and CCONJ dti-1425 3 9 recently recently ADV dti-1425 3 10 , , PUNCT dti-1425 3 11 gentamicin gentamicin NOUN dti-1425 3 12 - - PUNCT dti-1425 3 13 impregnated impregnate VERB dti-1425 3 14 collagen collagen NOUN dti-1425 3 15 sponges sponge NOUN dti-1425 3 16 ( ( PUNCT dti-1425 3 17 gicss gicss PROPN dti-1425 3 18 ) ) PUNCT dti-1425 3 19 have have AUX dti-1425 3 20 shown show VERB dti-1425 3 21 a a DET dti-1425 3 22 promising promising ADJ dti-1425 3 23 effect effect NOUN dti-1425 3 24 in in ADP dti-1425 3 25 reducing reduce VERB dti-1425 3 26 the the DET dti-1425 3 27 incidence incidence NOUN dti-1425 3 28 of of ADP dti-1425 3 29 this this DET dti-1425 3 30 type type NOUN dti-1425 3 31 of of ADP dti-1425 3 32 complications complication NOUN dti-1425 3 33 . . PUNCT dti-1425 4 1 gentamicin gentamicin PROPN dti-1425 4 2 is be AUX dti-1425 4 3 an an DET dti-1425 4 4 aminoglycoside aminoglycoside ADJ dti-1425 4 5 antibiotic antibiotic NOUN dti-1425 4 6 that that PRON dti-1425 4 7 has have AUX dti-1425 4 8 been be AUX dti-1425 4 9 widely widely ADV dti-1425 4 10 used use VERB dti-1425 4 11 to to PART dti-1425 4 12 treat treat VERB dti-1425 4 13 infections infection NOUN dti-1425 4 14 caused cause VERB dti-1425 4 15 by by ADP dti-1425 4 16 multiresistant multiresistant ADJ dti-1425 4 17 bacteria bacteria NOUN dti-1425 4 18 ; ; PUNCT dti-1425 4 19 despite despite SCONJ dti-1425 4 20 its its PRON dti-1425 4 21 effectiveness effectiveness NOUN dti-1425 4 22 , , PUNCT dti-1425 4 23 its its PRON dti-1425 4 24 systemic systemic ADJ dti-1425 4 25 use use NOUN dti-1425 4 26 carries carry VERB dti-1425 4 27 a a DET dti-1425 4 28 risk risk NOUN dti-1425 4 29 of of ADP dti-1425 4 30 toxicity toxicity NOUN dti-1425 4 31 . . PUNCT dti-1425 5 1 gicss gicss PROPN dti-1425 5 2 appear appear VERB dti-1425 5 3 to to PART dti-1425 5 4 overcome overcome VERB dti-1425 5 5 this this DET dti-1425 5 6 side side NOUN dti-1425 5 7 effect effect NOUN dti-1425 5 8 , , PUNCT dti-1425 5 9 topically topically ADV dti-1425 5 10 delivering deliver VERB dti-1425 5 11 high high ADJ dti-1425 5 12 antibiotic antibiotic ADJ dti-1425 5 13 concentrations concentration NOUN dti-1425 5 14 to to ADP dti-1425 5 15 the the DET dti-1425 5 16 wound wound NOUN dti-1425 5 17 and and CCONJ dti-1425 5 18 thus thus ADV dti-1425 5 19 reducing reduce VERB dti-1425 5 20 the the DET dti-1425 5 21 toxic toxic ADJ dti-1425 5 22 - - PUNCT dti-1425 5 23 related relate VERB dti-1425 5 24 events event NOUN dti-1425 5 25 . . PUNCT dti-1425 6 1 although although SCONJ dti-1425 6 2 several several ADJ dti-1425 6 3 retrospective retrospective ADJ dti-1425 6 4 analyses analysis NOUN dti-1425 6 5 and and CCONJ dti-1425 6 6 randomized randomize VERB dti-1425 6 7 controlled control VERB dti-1425 6 8 trials trial NOUN dti-1425 6 9 have have AUX dti-1425 6 10 studied study VERB dti-1425 6 11 the the DET dti-1425 6 12 use use NOUN dti-1425 6 13 of of ADP dti-1425 6 14 gicss gicss NOUN dti-1425 6 15 in in ADP dti-1425 6 16 cardiac cardiac ADJ dti-1425 6 17 surgery surgery NOUN dti-1425 6 18 , , PUNCT dti-1425 6 19 conclusions conclusion NOUN dti-1425 6 20 regarding regard VERB dti-1425 6 21 their their PRON dti-1425 6 22 efficacy efficacy NOUN dti-1425 6 23 in in ADP dti-1425 6 24 preventing prevent VERB dti-1425 6 25 sternal sternal ADJ dti-1425 6 26 wound wound NOUN dti-1425 6 27 infection infection NOUN dti-1425 6 28 are be AUX dti-1425 6 29 inconsistent inconsistent ADJ dti-1425 6 30 . . PUNCT dti-1425 7 1 we we PRON dti-1425 7 2 have have AUX dti-1425 7 3 reviewed review VERB dti-1425 7 4 the the DET dti-1425 7 5 current current ADJ dti-1425 7 6 literature literature NOUN dti-1425 7 7 focusing focus VERB dti-1425 7 8 on on ADP dti-1425 7 9 high high ADJ dti-1425 7 10 - - PUNCT dti-1425 7 11 risk risk NOUN dti-1425 7 12 patients patient NOUN dti-1425 7 13 . . PUNCT dti-1425 8 1 key key ADJ dti-1425 8 2 words word NOUN dti-1425 8 3 : : PUNCT dti-1425 8 4 gentamicin gentamicin NOUN dti-1425 8 5 , , PUNCT dti-1425 8 6 wound wound NOUN dti-1425 8 7 infection infection NOUN dti-1425 8 8 , , PUNCT dti-1425 8 9 topical topical ADJ dti-1425 8 10 drug drug NOUN dti-1425 8 11 administration administration NOUN dti-1425 8 12 supplement supplement NOUN dti-1425 8 13 : : PUNCT dti-1425 8 14 current current ADJ dti-1425 8 15 developments development NOUN dti-1425 8 16 in in ADP dti-1425 8 17 drug drug NOUN dti-1425 8 18 eluting eluting NOUN dti-1425 8 19 devices device NOUN dti-1425 8 20 citation citation NOUN dti-1425 8 21 : : PUNCT dti-1425 8 22 rapetto rapetto NOUN dti-1425 8 23 et et PROPN dti-1425 8 24 al al PROPN dti-1425 8 25 . . PROPN dti-1425 8 26 gentamicin gentamicin PROPN dti-1425 8 27 - - PUNCT dti-1425 8 28 impregnated impregnate VERB dti-1425 8 29 collagen collagen NOUN dti-1425 8 30 sponge sponge NOUN dti-1425 8 31 : : PUNCT dti-1425 8 32 effectiveness effectiveness NOUN dti-1425 8 33 in in ADP dti-1425 8 34 preventing prevent VERB dti-1425 8 35 sternal sternal ADJ dti-1425 8 36 wound wound NOUN dti-1425 8 37 infection infection NOUN dti-1425 8 38 in in ADP dti-1425 8 39 high high ADJ dti-1425 8 40 - - PUNCT dti-1425 8 41 risk risk NOUN dti-1425 8 42 cardiac cardiac ADJ dti-1425 8 43 surgery surgery NOUN dti-1425 8 44 . . PUNCT dti-1425 9 1 drug drug NOUN dti-1425 9 2 target target NOUN dti-1425 9 3 insights insight NOUN dti-1425 9 4 2016:10(s1 2016:10(s1 NUM dti-1425 9 5 ) ) PUNCT dti-1425 9 6 9–13 9–13 NOUN dti-1425 9 7 doi:10.4137 doi:10.4137 NOUN dti-1425 9 8 / / SYM dti-1425 9 9 dti.s39077 dti.s39077 NOUN dti-1425 9 10 . . PUNCT dti-1425 10 1 type type NOUN dti-1425 10 2 : : PUNCT dti-1425 10 3 consise consise PROPN dti-1425 10 4 review review NOUN dti-1425 10 5 received receive VERB dti-1425 10 6 : : PUNCT dti-1425 10 7 february february PROPN dti-1425 10 8 5 5 NUM dti-1425 10 9 , , PUNCT dti-1425 10 10 2016 2016 NUM dti-1425 10 11 . . PUNCT dti-1425 11 1 resubmitted resubmitte VERB dti-1425 11 2 : : PUNCT dti-1425 11 3 april april PROPN dti-1425 11 4 5 5 NUM dti-1425 11 5 , , PUNCT dti-1425 11 6 2016 2016 NUM dti-1425 11 7 . . PUNCT dti-1425 12 1 accepted accept VERB dti-1425 12 2 for for ADP dti-1425 12 3 publication publication NOUN dti-1425 12 4 : : PUNCT dti-1425 12 5 april april PROPN dti-1425 12 6 11 11 NUM dti-1425 12 7 , , PUNCT dti-1425 12 8 2016 2016 NUM dti-1425 12 9 . . PUNCT dti-1425 13 1 academic academic ADJ dti-1425 13 2 editor editor NOUN dti-1425 13 3 : : PUNCT dti-1425 13 4 anuj anuj PROPN dti-1425 13 5 chauhan chauhan PROPN dti-1425 13 6 , , PUNCT dti-1425 13 7 editor editor NOUN dti-1425 13 8 in in ADP dti-1425 13 9 chief chief ADJ dti-1425 13 10 peer peer NOUN dti-1425 13 11 review review NOUN dti-1425 13 12 : : PUNCT dti-1425 13 13 three three NUM dti-1425 13 14 peer peer NOUN dti-1425 13 15 reviewers reviewer NOUN dti-1425 13 16 contributed contribute VERB dti-1425 13 17 to to ADP dti-1425 13 18 the the DET dti-1425 13 19 peer peer NOUN dti-1425 13 20 review review NOUN dti-1425 13 21 report report NOUN dti-1425 13 22 . . PUNCT dti-1425 14 1 reviewers reviewer NOUN dti-1425 14 2 ’ ' PUNCT dti-1425 14 3 reports report NOUN dti-1425 14 4 totaled total VERB dti-1425 14 5 333 333 NUM dti-1425 14 6 words word NOUN dti-1425 14 7 , , PUNCT dti-1425 14 8 excluding exclude VERB dti-1425 14 9 any any DET dti-1425 14 10 confidential confidential ADJ dti-1425 14 11 comments comment NOUN dti-1425 14 12 to to ADP dti-1425 14 13 the the DET dti-1425 14 14 academic academic ADJ dti-1425 14 15 editor editor NOUN dti-1425 14 16 . . PUNCT dti-1425 15 1 funding funding NOUN dti-1425 15 2 : : PUNCT dti-1425 15 3 authors author NOUN dti-1425 15 4 disclose disclose VERB dti-1425 15 5 no no DET dti-1425 15 6 external external ADJ dti-1425 15 7 funding funding NOUN dti-1425 15 8 sources source NOUN dti-1425 15 9 . . PUNCT dti-1425 16 1 competing compete VERB dti-1425 16 2 interests interest NOUN dti-1425 16 3 : : PUNCT dti-1425 16 4 authors author NOUN dti-1425 16 5 disclose disclose VERB dti-1425 16 6 no no DET dti-1425 16 7 potential potential ADJ dti-1425 16 8 conflicts conflict NOUN dti-1425 16 9 of of ADP dti-1425 16 10 interest interest NOUN dti-1425 16 11 . . PUNCT dti-1425 17 1 copyright copyright NOUN dti-1425 17 2 : : PUNCT dti-1425 17 3 © © PROPN dti-1425 17 4 the the DET dti-1425 17 5 authors author NOUN dti-1425 17 6 , , PUNCT dti-1425 17 7 publisher publisher NOUN dti-1425 17 8 and and CCONJ dti-1425 17 9 licensee licensee NOUN dti-1425 17 10 libertas liberta NOUN dti-1425 17 11 academica academica PROPN dti-1425 17 12 limited limit VERB dti-1425 17 13 . . PUNCT dti-1425 18 1 this this PRON dti-1425 18 2 is be AUX dti-1425 18 3 an an DET dti-1425 18 4 open open ADJ dti-1425 18 5 - - PUNCT dti-1425 18 6 access access NOUN dti-1425 18 7 article article NOUN dti-1425 18 8 distributed distribute VERB dti-1425 18 9 under under ADP dti-1425 18 10 the the DET dti-1425 18 11 terms term NOUN dti-1425 18 12 of of ADP dti-1425 18 13 the the DET dti-1425 18 14 creative creative ADJ dti-1425 18 15 commons common NOUN dti-1425 18 16 cc cc NOUN dti-1425 18 17 - - PUNCT dti-1425 18 18 by by ADP dti-1425 18 19 - - PUNCT dti-1425 18 20 nc nc PROPN dti-1425 18 21 3.0 3.0 NUM dti-1425 18 22 license license NOUN dti-1425 18 23 . . PUNCT dti-1425 19 1 correspondence correspondence NOUN dti-1425 19 2 : : PUNCT dti-1425 20 1 vitodomenicobruno@gmail.com vitodomenicobruno@gmail.com X dti-1425 20 2 paper paper PROPN dti-1425 20 3 subject subject NOUN dti-1425 20 4 to to ADP dti-1425 20 5 independent independent ADJ dti-1425 20 6 expert expert ADJ dti-1425 20 7 single single ADJ dti-1425 20 8 - - PUNCT dti-1425 20 9 blind blind ADJ dti-1425 20 10 peer peer NOUN dti-1425 20 11 review review NOUN dti-1425 20 12 . . PUNCT dti-1425 21 1 all all DET dti-1425 21 2 editorial editorial ADJ dti-1425 21 3 decisions decision NOUN dti-1425 21 4 made make VERB dti-1425 21 5 by by ADP dti-1425 21 6 independent independent ADJ dti-1425 21 7 academic academic ADJ dti-1425 21 8 editor editor NOUN dti-1425 21 9 . . PUNCT dti-1425 22 1 upon upon SCONJ dti-1425 22 2 submission submission NOUN dti-1425 22 3 manuscript manuscript NOUN dti-1425 22 4 was be AUX dti-1425 22 5 subject subject ADJ dti-1425 22 6 to to ADP dti-1425 22 7 anti anti ADJ dti-1425 22 8 - - NOUN dti-1425 22 9 plagiarism plagiarism ADJ dti-1425 22 10 scanning scanning NOUN dti-1425 22 11 . . PUNCT dti-1425 23 1 prior prior ADV dti-1425 23 2 to to ADP dti-1425 23 3 publication publication NOUN dti-1425 23 4 all all DET dti-1425 23 5 authors author NOUN dti-1425 23 6 have have AUX dti-1425 23 7 given give VERB dti-1425 23 8 signed sign VERB dti-1425 23 9 confirmation confirmation NOUN dti-1425 23 10 of of ADP dti-1425 23 11 agreement agreement NOUN dti-1425 23 12 to to ADP dti-1425 23 13 article article NOUN dti-1425 23 14 publication publication NOUN dti-1425 23 15 and and CCONJ dti-1425 23 16 compliance compliance NOUN dti-1425 23 17 with with ADP dti-1425 23 18 all all DET dti-1425 23 19 applicable applicable ADJ dti-1425 23 20 ethical ethical ADJ dti-1425 23 21 and and CCONJ dti-1425 23 22 legal legal ADJ dti-1425 23 23 requirements requirement NOUN dti-1425 23 24 , , PUNCT dti-1425 23 25 including include VERB dti-1425 23 26 the the DET dti-1425 23 27 accuracy accuracy NOUN dti-1425 23 28 of of ADP dti-1425 23 29 author author NOUN dti-1425 23 30 and and CCONJ dti-1425 23 31 contributor contributor NOUN dti-1425 23 32 information information NOUN dti-1425 23 33 , , PUNCT dti-1425 23 34 disclosure disclosure NOUN dti-1425 23 35 of of ADP dti-1425 23 36 competing compete VERB dti-1425 23 37 interests interest NOUN dti-1425 23 38 and and CCONJ dti-1425 23 39 funding funding NOUN dti-1425 23 40 sources source NOUN dti-1425 23 41 , , PUNCT dti-1425 23 42 compliance compliance NOUN dti-1425 23 43 with with ADP dti-1425 23 44 ethical ethical ADJ dti-1425 23 45 requirements requirement NOUN dti-1425 23 46 relating relate VERB dti-1425 23 47 to to ADP dti-1425 23 48 human human ADJ dti-1425 23 49 and and CCONJ dti-1425 23 50 animal animal NOUN dti-1425 23 51 study study NOUN dti-1425 23 52 participants participant NOUN dti-1425 23 53 , , PUNCT dti-1425 23 54 and and CCONJ dti-1425 23 55 compliance compliance NOUN dti-1425 23 56 with with ADP dti-1425 23 57 any any DET dti-1425 23 58 copyright copyright NOUN dti-1425 23 59 requirements requirement NOUN dti-1425 23 60 of of ADP dti-1425 23 61 third third ADJ dti-1425 23 62 parties party NOUN dti-1425 23 63 . . PUNCT dti-1425 24 1 this this DET dti-1425 24 2 journal journal NOUN dti-1425 24 3 is be AUX dti-1425 24 4 a a DET dti-1425 24 5 member member NOUN dti-1425 24 6 of of ADP dti-1425 24 7 the the DET dti-1425 24 8 committee committee NOUN dti-1425 24 9 on on ADP dti-1425 24 10 publication publication NOUN dti-1425 24 11 ethics ethic NOUN dti-1425 24 12 ( ( PUNCT dti-1425 24 13 cope cope PROPN dti-1425 24 14 ) ) PUNCT dti-1425 24 15 . . PUNCT dti-1425 25 1 published publish VERB dti-1425 25 2 by by ADP dti-1425 25 3 libertas liberta NOUN dti-1425 25 4 academica academica PROPN dti-1425 25 5 . . PUNCT dti-1425 26 1 learn learn VERB dti-1425 26 2 more more ADJ dti-1425 26 3 about about ADP dti-1425 26 4 this this DET dti-1425 26 5 journal journal NOUN dti-1425 26 6 . . PUNCT dti-1425 27 1 introduction introduction NOUN dti-1425 27 2 sternal sternal ADJ dti-1425 27 3 wound wound NOUN dti-1425 27 4 infections infection NOUN dti-1425 27 5 ( ( PUNCT dti-1425 27 6 swis swis NOUN dti-1425 27 7 ) ) PUNCT dti-1425 27 8 represent represent VERB dti-1425 27 9 one one NUM dti-1425 27 10 of of ADP dti-1425 27 11 the the DET dti-1425 27 12 most most ADV dti-1425 27 13 challenging challenging ADJ dti-1425 27 14 postoperative postoperative ADJ dti-1425 27 15 complications complication NOUN dti-1425 27 16 following follow VERB dti-1425 27 17 cardiac cardiac ADJ dti-1425 27 18 surgery surgery NOUN dti-1425 27 19 , , PUNCT dti-1425 27 20 associated associate VERB dti-1425 27 21 with with ADP dti-1425 27 22 increased increase VERB dti-1425 27 23 hospital hospital NOUN dti-1425 27 24 stay stay NOUN dti-1425 27 25 , , PUNCT dti-1425 27 26 mortality mortality NOUN dti-1425 27 27 , , PUNCT dti-1425 27 28 and and CCONJ dti-1425 27 29 costs.1 costs.1 NOUN dti-1425 27 30 it it PRON dti-1425 27 31 is be AUX dti-1425 27 32 widely widely ADV dti-1425 27 33 acknowledged acknowledge VERB dti-1425 27 34 that that SCONJ dti-1425 27 35 several several ADJ dti-1425 27 36 factors factor NOUN dti-1425 27 37 ( ( PUNCT dti-1425 27 38 eg eg NOUN dti-1425 27 39 , , PUNCT dti-1425 27 40 smoking smoking NOUN dti-1425 27 41 , , PUNCT dti-1425 27 42 obesity obesity NOUN dti-1425 27 43 , , PUNCT dti-1425 27 44 insulin insulin NOUN dti-1425 27 45 - - PUNCT dti-1425 27 46 dependent dependent ADJ dti-1425 27 47 diabetes diabetes NOUN dti-1425 27 48 , , PUNCT dti-1425 27 49 emergent emergent ADJ dti-1425 27 50 surgery surgery NOUN dti-1425 27 51 , , PUNCT dti-1425 27 52 prolonged prolonged ADJ dti-1425 27 53 operative operative ADJ dti-1425 27 54 time time NOUN dti-1425 27 55 , , PUNCT dti-1425 27 56 reoperation reoperation NOUN dti-1425 27 57 , , PUNCT dti-1425 27 58 bilateral bilateral ADJ dti-1425 27 59 internal internal ADJ dti-1425 27 60 mammary mammary ADJ dti-1425 27 61 artery artery NOUN dti-1425 27 62 ( ( PUNCT dti-1425 27 63 bima bima PROPN dti-1425 27 64 ) ) PUNCT dti-1425 27 65 harvesting harvesting NOUN dti-1425 27 66 , , PUNCT dti-1425 27 67 transfusions transfusion NOUN dti-1425 27 68 , , PUNCT dti-1425 27 69 and and CCONJ dti-1425 27 70 prolonged prolonged ADJ dti-1425 27 71 ventilation ventilation NOUN dti-1425 27 72 / / SYM dti-1425 27 73 intensive intensive ADJ dti-1425 27 74 care care NOUN dti-1425 27 75 unit unit NOUN dti-1425 27 76 [ [ X dti-1425 27 77 icu icu X dti-1425 27 78 ] ] PUNCT dti-1425 27 79 stay stay NOUN dti-1425 27 80 ) ) PUNCT dti-1425 27 81 pre pre VERB dti-1425 27 82 dispose dispose ADJ dti-1425 27 83 to to ADP dti-1425 27 84 a a DET dti-1425 27 85 higher high ADJ dti-1425 27 86 risk risk NOUN dti-1425 27 87 of of ADP dti-1425 27 88 both both CCONJ dti-1425 27 89 superficial superficial ADJ dti-1425 27 90 and and CCONJ dti-1425 27 91 deep deep ADJ dti-1425 27 92 swis swis NOUN dti-1425 27 93 ; ; PUNCT dti-1425 27 94 many many ADJ dti-1425 27 95 of of ADP dti-1425 27 96 these these DET dti-1425 27 97 conditions condition NOUN dti-1425 27 98 are be AUX dti-1425 27 99 observed observe VERB dti-1425 27 100 with with ADP dti-1425 27 101 increasing increase VERB dti-1425 27 102 frequency frequency NOUN dti-1425 27 103 in in ADP dti-1425 27 104 the the DET dti-1425 27 105 modern modern ADJ dti-1425 27 106 cardiac cardiac ADJ dti-1425 27 107 surgery surgery NOUN dti-1425 27 108 scenario.2–4 scenario.2–4 NOUN dti-1425 27 109 historically historically ADV dti-1425 27 110 , , PUNCT dti-1425 27 111 the the DET dti-1425 27 112 cornerstones cornerstone NOUN dti-1425 27 113 of of ADP dti-1425 27 114 prevention prevention NOUN dti-1425 27 115 of of ADP dti-1425 27 116 swis swis NOUN dti-1425 27 117 have have AUX dti-1425 27 118 been be AUX dti-1425 27 119 preoperative preoperative ADJ dti-1425 27 120 skin skin NOUN dti-1425 27 121 asepsis asepsis NOUN dti-1425 27 122 and and CCONJ dti-1425 27 123 administration administration NOUN dti-1425 27 124 of of ADP dti-1425 27 125 prophylactic prophylactic ADJ dti-1425 27 126 antimicrobial antimicrobial ADJ dti-1425 27 127 drugs drug NOUN dti-1425 27 128 and and CCONJ dti-1425 27 129 several several ADJ dti-1425 27 130 surgical surgical ADJ dti-1425 27 131 maneuvers maneuver NOUN dti-1425 27 132 intended intend VERB dti-1425 27 133 to to PART dti-1425 27 134 maintain maintain VERB dti-1425 27 135 sterility sterility NOUN dti-1425 27 136 and and CCONJ dti-1425 27 137 achieve achieve VERB dti-1425 27 138 a a DET dti-1425 27 139 stable stable ADJ dti-1425 27 140 sternal sternal NOUN dti-1425 27 141 fixation.5–7 fixation.5–7 ADJ dti-1425 27 142 during during ADP dti-1425 27 143 the the DET dti-1425 27 144 past past ADJ dti-1425 27 145 few few ADJ dti-1425 27 146 years year NOUN dti-1425 27 147 , , PUNCT dti-1425 27 148 local local ADJ dti-1425 27 149 administration administration NOUN dti-1425 27 150 of of ADP dti-1425 27 151 gentamicin gentamicin PROPN dti-1425 27 152 through through ADP dti-1425 27 153 a a DET dti-1425 27 154 surgically surgically ADV dti-1425 27 155 inserted insert VERB dti-1425 27 156 collagen collagen NOUN dti-1425 27 157 sponge sponge NOUN dti-1425 27 158 has have AUX dti-1425 27 159 been be AUX dti-1425 27 160 gaining gain VERB dti-1425 27 161 popularity popularity NOUN dti-1425 27 162 in in ADP dti-1425 27 163 different different ADJ dti-1425 27 164 surgical surgical ADJ dti-1425 27 165 fields field NOUN dti-1425 27 166 , , PUNCT dti-1425 27 167 and and CCONJ dti-1425 27 168 it it PRON dti-1425 27 169 has have AUX dti-1425 27 170 been be AUX dti-1425 27 171 increasingly increasingly ADV dti-1425 27 172 used use VERB dti-1425 27 173 in in ADP dti-1425 27 174 cardiac cardiac NOUN dti-1425 27 175 surgery.8 surgery.8 ADP dti-1425 27 176 the the DET dti-1425 27 177 reported report VERB dti-1425 27 178 incidence incidence NOUN dti-1425 27 179 of of ADP dti-1425 27 180 swis swis NOUN dti-1425 27 181 varies vary VERB dti-1425 27 182 between between ADP dti-1425 27 183 0.5 0.5 NUM dti-1425 27 184 % % NOUN dti-1425 27 185 and and CCONJ dti-1425 27 186 6 6 NUM dti-1425 27 187 % % NOUN dti-1425 27 188 throughout throughout ADP dti-1425 27 189 the the DET dti-1425 27 190 literature literature NOUN dti-1425 27 191 , , PUNCT dti-1425 27 192 although although SCONJ dti-1425 27 193 it it PRON dti-1425 27 194 is be AUX dti-1425 27 195 considerably considerably ADV dti-1425 27 196 higher high ADJ dti-1425 27 197 among among ADP dti-1425 27 198 high high ADJ dti-1425 27 199 - - PUNCT dti-1425 27 200 risk risk NOUN dti-1425 27 201 individuals individual NOUN dti-1425 27 202 , , PUNCT dti-1425 27 203 ranging range VERB dti-1425 27 204 between between ADP dti-1425 27 205 12 12 NUM dti-1425 27 206 % % NOUN dti-1425 27 207 and and CCONJ dti-1425 27 208 20%.6 20%.6 NUM dti-1425 27 209 swis swis NOUN dti-1425 27 210 can can AUX dti-1425 27 211 be be AUX dti-1425 27 212 classified classify VERB dti-1425 27 213 as as ADP dti-1425 27 214 super super ADJ dti-1425 27 215 ficial ficial ADJ dti-1425 27 216 swis swis NOUN dti-1425 27 217 ( ( PUNCT dti-1425 27 218 sswis sswis NOUN dti-1425 27 219 ) ) PUNCT dti-1425 27 220 or or CCONJ dti-1425 27 221 deep deep ADJ dti-1425 27 222 swis swis NOUN dti-1425 27 223 ( ( PUNCT dti-1425 27 224 dswis dswis NOUN dti-1425 27 225 ) ) PUNCT dti-1425 27 226 , , PUNCT dti-1425 27 227 according accord VERB dti-1425 27 228 to to ADP dti-1425 27 229 the the DET dti-1425 27 230 extension extension NOUN dti-1425 27 231 of of ADP dti-1425 27 232 the the DET dti-1425 27 233 infective infective ADJ dti-1425 27 234 process process NOUN dti-1425 27 235 from from ADP dti-1425 27 236 the the DET dti-1425 27 237 skin skin NOUN dti-1425 27 238 and and CCONJ dti-1425 27 239 subcutaneous subcutaneous ADJ dti-1425 27 240 layer layer NOUN dti-1425 27 241 to to ADP dti-1425 27 242 the the DET dti-1425 27 243 bone bone NOUN dti-1425 27 244 and and CCONJ dti-1425 27 245 mediastinum mediastinum NOUN dti-1425 27 246 . . PUNCT dti-1425 28 1 the the DET dti-1425 28 2 centers center NOUN dti-1425 28 3 for for ADP dti-1425 28 4 disease disease NOUN dti-1425 28 5 control control NOUN dti-1425 28 6 and and CCONJ dti-1425 28 7 prevention prevention NOUN dti-1425 28 8 and and CCONJ dti-1425 28 9 the the DET dti-1425 28 10 national national PROPN dti-1425 28 11 institute institute PROPN dti-1425 28 12 of of ADP dti-1425 28 13 clinical clinical PROPN dti-1425 28 14 excellence excellence PROPN dti-1425 28 15 have have AUX dti-1425 28 16 developed develop VERB dti-1425 28 17 guidelines guideline NOUN dti-1425 28 18 for for ADP dti-1425 28 19 the the DET dti-1425 28 20 diagnosis diagnosis NOUN dti-1425 28 21 and and CCONJ dti-1425 28 22 management management NOUN dti-1425 28 23 of of ADP dti-1425 28 24 surgical surgical ADJ dti-1425 28 25 site site NOUN dti-1425 28 26 infections.9,10 infections.9,10 VERB dti-1425 28 27 however however ADV dti-1425 28 28 , , PUNCT dti-1425 28 29 currently currently ADV dti-1425 28 30 , , PUNCT dti-1425 28 31 the the DET dti-1425 28 32 assessment assessment NOUN dti-1425 28 33 and and CCONJ dti-1425 28 34 treatment treatment NOUN dti-1425 28 35 of of ADP dti-1425 28 36 swis swis NOUN dti-1425 28 37 seem seem VERB dti-1425 28 38 to to PART dti-1425 28 39 be be AUX dti-1425 28 40 quite quite ADV dti-1425 28 41 heterogeneous heterogeneous ADJ dti-1425 28 42 among among ADP dti-1425 28 43 different different ADJ dti-1425 28 44 centers center NOUN dti-1425 28 45 and and CCONJ dti-1425 28 46 even even ADV dti-1425 28 47 among among ADP dti-1425 28 48 different different ADJ dti-1425 28 49 surgeons surgeon NOUN dti-1425 28 50 from from ADP dti-1425 28 51 the the DET dti-1425 28 52 same same ADJ dti-1425 28 53 center center NOUN dti-1425 28 54 . . PUNCT dti-1425 29 1 it it PRON dti-1425 29 2 is be AUX dti-1425 29 3 clear clear ADJ dti-1425 29 4 that that SCONJ dti-1425 29 5 dswis dswis NOUN dti-1425 29 6 strongly strongly ADV dti-1425 29 7 impact impact VERB dti-1425 29 8 on on ADP dti-1425 29 9 postoperative postoperative ADJ dti-1425 29 10 morbidity morbidity NOUN dti-1425 29 11 and and CCONJ dti-1425 29 12 mortality mortality NOUN dti-1425 29 13 and and CCONJ dti-1425 29 14 that that DET dti-1425 29 15 sswis sswis NOUN dti-1425 29 16 are be AUX dti-1425 29 17 a a DET dti-1425 29 18 common common ADJ dti-1425 29 19 cause cause NOUN dti-1425 29 20 of of ADP dti-1425 29 21 prolonged prolonged ADJ dti-1425 29 22 hospital hospital NOUN dti-1425 29 23 stay stay NOUN dti-1425 29 24 . . PUNCT dti-1425 30 1 in in ADP dti-1425 30 2 2008 2008 NUM dti-1425 30 3 , , PUNCT dti-1425 30 4 mauermann mauermann PROPN dti-1425 30 5 et et PROPN dti-1425 30 6 al al PROPN dti-1425 30 7 reviewed review VERB dti-1425 30 8 data datum NOUN dti-1425 30 9 regarding regard VERB dti-1425 30 10 11 11 NUM dti-1425 30 11 series series NOUN dti-1425 30 12 of of ADP dti-1425 30 13 postoperative postoperative ADJ dti-1425 30 14 swis swis NOUN dti-1425 30 15 , , PUNCT dti-1425 30 16 reporting report VERB dti-1425 30 17 an an DET dti-1425 30 18 overall overall ADJ dti-1425 30 19 mortality mortality NOUN dti-1425 30 20 of of ADP dti-1425 30 21 13 13 NUM dti-1425 30 22 % % NOUN dti-1425 30 23 ( ( PUNCT dti-1425 30 24 ranging range VERB dti-1425 30 25 between between ADP dti-1425 30 26 6 6 NUM dti-1425 30 27 % % NOUN dti-1425 30 28 and and CCONJ dti-1425 30 29 30 30 NUM dti-1425 30 30 % % NOUN dti-1425 30 31 ) ) PUNCT dti-1425 30 32 . . PUNCT dti-1425 31 1 they they PRON dti-1425 31 2 also also ADV dti-1425 31 3 concluded conclude VERB dti-1425 31 4 that that SCONJ dti-1425 31 5 it it PRON dti-1425 31 6 is be AUX dti-1425 31 7 difficult difficult ADJ dti-1425 31 8 to to PART dti-1425 31 9 precisely precisely ADV dti-1425 31 10 assess assess VERB dti-1425 31 11 the the DET dti-1425 31 12 impact impact NOUN dti-1425 31 13 of of ADP dti-1425 31 14 swis swis NOUN dti-1425 31 15 on on ADP dti-1425 31 16 hospital hospital NOUN dti-1425 31 17 costs cost NOUN dti-1425 31 18 due due ADP dti-1425 31 19 to to ADP dti-1425 31 20 the the DET dti-1425 31 21 variability variability NOUN dti-1425 31 22 in in ADP dti-1425 31 23 protocols protocol NOUN dti-1425 31 24 among among ADP dti-1425 31 25 different different ADJ dti-1425 31 26 centers.1 centers.1 NOUN dti-1425 31 27 since since SCONJ dti-1425 31 28 swis swis NOUN dti-1425 31 29 significantly significantly ADV dti-1425 31 30 prolong prolong VERB dti-1425 31 31 icu icu PROPN dti-1425 31 32 stay stay NOUN dti-1425 31 33 and and CCONJ dti-1425 31 34 hospitalization hospitalization NOUN dti-1425 31 35 , , PUNCT dti-1425 31 36 they they PRON dti-1425 31 37 are be AUX dti-1425 31 38 widely widely ADV dti-1425 31 39 known know VERB dti-1425 31 40 to to PART dti-1425 31 41 be be AUX dti-1425 31 42 a a DET dti-1425 31 43 major major ADJ dti-1425 31 44 cause cause NOUN dti-1425 31 45 of of ADP dti-1425 31 46 increased increase VERB dti-1425 31 47 health health NOUN dti-1425 31 48 - - PUNCT dti-1425 31 49 care care NOUN dti-1425 31 50 costs cost NOUN dti-1425 31 51 in in ADP dti-1425 31 52 cardiac cardiac ADJ dti-1425 31 53 surgery.1 surgery.1 NOUN dti-1425 31 54 both both DET dti-1425 31 55 dswis dswis NOUN dti-1425 31 56 and and CCONJ dti-1425 31 57 sswis sswis NOUN dti-1425 31 58 are be AUX dti-1425 31 59 usually usually ADV dti-1425 31 60 caused cause VERB dti-1425 31 61 by by ADP dti-1425 31 62 gram gram NOUN dti-1425 31 63 - - PUNCT dti-1425 31 64 positive positive ADJ dti-1425 31 65 skin skin NOUN dti-1425 31 66 bacteria bacteria NOUN dti-1425 31 67 such such ADJ dti-1425 31 68 as as ADP dti-1425 31 69 coagulasenegative coagulasenegative ADJ dti-1425 31 70 staphylococci staphylococci NOUN dti-1425 31 71 ( ( PUNCT dti-1425 31 72 cons con NOUN dti-1425 31 73 ) ) PUNCT dti-1425 31 74 and and CCONJ dti-1425 31 75 staphylococcus staphylococcus NOUN dti-1425 31 76 aureus aureus NOUN dti-1425 31 77 ; ; PUNCT dti-1425 31 78 in in ADP dti-1425 31 79 a a DET dti-1425 31 80 minority minority NOUN dti-1425 31 81 of of ADP dti-1425 31 82 cases case NOUN dti-1425 31 83 , , PUNCT dti-1425 31 84 they they PRON dti-1425 31 85 can can AUX dti-1425 31 86 be be AUX dti-1425 31 87 caused cause VERB dti-1425 31 88 by by ADP dti-1425 31 89 gram gram NOUN dti-1425 31 90 - - PUNCT dti-1425 31 91 negative negative ADJ dti-1425 31 92 rods rod NOUN dti-1425 31 93 journal journal NOUN dti-1425 31 94 name name NOUN dti-1425 31 95 : : PUNCT dti-1425 31 96 drug drug NOUN dti-1425 31 97 target target NOUN dti-1425 31 98 insights insight NOUN dti-1425 31 99 journal journal NOUN dti-1425 31 100 type type NOUN dti-1425 31 101 : : PUNCT dti-1425 31 102 consise consise PROPN dti-1425 31 103 review review NOUN dti-1425 31 104 year year NOUN dti-1425 31 105 : : PUNCT dti-1425 31 106 2016 2016 NUM dti-1425 31 107 volume volume NOUN dti-1425 31 108 : : PUNCT dti-1425 31 109 10(s1 10(s1 NUM dti-1425 31 110 ) ) PUNCT dti-1425 31 111 running run VERB dti-1425 31 112 head head NOUN dti-1425 31 113 verso verso NOUN dti-1425 31 114 : : PUNCT dti-1425 31 115 rapetto rapetto NOUN dti-1425 31 116 et et PROPN dti-1425 31 117 al al PROPN dti-1425 31 118 running run VERB dti-1425 31 119 head head NOUN dti-1425 31 120 recto recto NOUN dti-1425 31 121 : : PUNCT dti-1425 31 122 effectiveness effectiveness NOUN dti-1425 31 123 of of ADP dti-1425 31 124 gentamicin gentamicin NOUN dti-1425 31 125 - - PUNCT dti-1425 31 126 impregnated impregnate VERB dti-1425 31 127 collagen collagen NOUN dti-1425 31 128 sponge sponge NOUN dti-1425 31 129 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1425 31 130 http://www.la-press.com http://www.la-press.com X dti-1425 31 131 http://dx.doi.org/10.4137/dti.s39077 http://dx.doi.org/10.4137/dti.s39077 PROPN dti-1425 31 132 http://creativecommons.org/licenses/by-nc/3.0/ http://creativecommons.org/licenses/by-nc/3.0/ PROPN dti-1425 31 133 http://creativecommons.org/licenses/by-nc/3.0/ http://creativecommons.org/licenses/by-nc/3.0/ PROPN dti-1425 31 134 mailto:vitodomenicobruno@gmail.com mailto:vitodomenicobruno@gmail.com VERB dti-1425 31 135 http://www.la-press.com http://www.la-press.com X dti-1425 31 136 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1425 31 137 rapetto rapetto PROPN dti-1425 31 138 et et PROPN dti-1425 31 139 al al PROPN dti-1425 31 140 10 10 NUM dti-1425 31 141 drug drug NOUN dti-1425 31 142 target target NOUN dti-1425 31 143 insights insight NOUN dti-1425 31 144 2016:10(s1 2016:10(s1 NUM dti-1425 31 145 ) ) PUNCT dti-1425 31 146 such such ADJ dti-1425 31 147 as as ADP dti-1425 31 148 escherichia escherichia NOUN dti-1425 31 149 coli coli NOUN dti-1425 31 150 and and CCONJ dti-1425 31 151 pseudomonas pseudomona NOUN dti-1425 31 152 aeruginosa aeruginosa NOUN dti-1425 31 153 and and CCONJ dti-1425 31 154 fungi fungus NOUN dti-1425 31 155 such such ADJ dti-1425 31 156 as as ADP dti-1425 31 157 candida candida NOUN dti-1425 31 158 albicans.11–13 albicans.11–13 NOUN dti-1425 31 159 as as SCONJ dti-1425 31 160 shown show VERB dti-1425 31 161 in in ADP dti-1425 31 162 table table NOUN dti-1425 31 163 1 1 NUM dti-1425 31 164 , , PUNCT dti-1425 31 165 grampositive grampositive ADJ dti-1425 31 166 bacteria bacteria NOUN dti-1425 31 167 are be AUX dti-1425 31 168 isolated isolate VERB dti-1425 31 169 in in ADP dti-1425 31 170 60%–80 60%–80 NUM dti-1425 31 171 % % NOUN dti-1425 31 172 of of ADP dti-1425 31 173 postoperative postoperative ADJ dti-1425 31 174 swis swis NOUN dti-1425 31 175 , , PUNCT dti-1425 31 176 gram gram NOUN dti-1425 31 177 - - PUNCT dti-1425 31 178 negative negative ADJ dti-1425 31 179 rods rod NOUN dti-1425 31 180 in in ADP dti-1425 31 181 20%–40 20%–40 NUM dti-1425 31 182 % % NOUN dti-1425 31 183 of of ADP dti-1425 31 184 cases case NOUN dti-1425 31 185 , , PUNCT dti-1425 31 186 and and CCONJ dti-1425 31 187 fungi fungi VERB dti-1425 31 188 in in ADP dti-1425 31 189 about about ADV dti-1425 31 190 5 5 NUM dti-1425 31 191 % % NOUN dti-1425 31 192 ( ( PUNCT dti-1425 31 193 polymicrobial polymicrobial ADJ dti-1425 31 194 isolations isolation NOUN dti-1425 31 195 are be AUX dti-1425 31 196 frequent frequent ADJ dti-1425 31 197 and and CCONJ dti-1425 31 198 occur occur VERB dti-1425 31 199 in in ADP dti-1425 31 200 10%–40 10%–40 NUM dti-1425 31 201 % % NOUN dti-1425 31 202 of of ADP dti-1425 31 203 cases).1,14,15 cases).1,14,15 ADJ dti-1425 31 204 the the DET dti-1425 31 205 emergence emergence NOUN dti-1425 31 206 of of ADP dti-1425 31 207 multiresistant multiresistant ADJ dti-1425 31 208 bacterial bacterial ADJ dti-1425 31 209 strains strain NOUN dti-1425 31 210 has have AUX dti-1425 31 211 led lead VERB dti-1425 31 212 to to ADP dti-1425 31 213 a a DET dti-1425 31 214 challenging challenging ADJ dti-1425 31 215 situation situation NOUN dti-1425 31 216 : : PUNCT dti-1425 31 217 beta beta NOUN dti-1425 31 218 - - PUNCT dti-1425 31 219 lactam lactam NOUN dti-1425 31 220 antibiotics antibiotic NOUN dti-1425 31 221 have have AUX dti-1425 31 222 become become VERB dti-1425 31 223 ineffective ineffective ADJ dti-1425 31 224 against against ADP dti-1425 31 225 most most ADJ dti-1425 31 226 cons con NOUN dti-1425 31 227 and and CCONJ dti-1425 31 228 s. s. PROPN dti-1425 31 229 aureus aureus PROPN dti-1425 31 230 clusters cluster NOUN dti-1425 31 231 , , PUNCT dti-1425 31 232 and and CCONJ dti-1425 31 233 the the DET dti-1425 31 234 routine routine ADJ dti-1425 31 235 use use NOUN dti-1425 31 236 of of ADP dti-1425 31 237 vancomycin vancomycin PROPN dti-1425 31 238 as as ADP dti-1425 31 239 a a DET dti-1425 31 240 prophylactic prophylactic ADJ dti-1425 31 241 agent agent NOUN dti-1425 31 242 is be AUX dti-1425 31 243 not not PART dti-1425 31 244 advisable advisable ADJ dti-1425 31 245 in in ADP dti-1425 31 246 order order NOUN dti-1425 31 247 to to PART dti-1425 31 248 avoid avoid VERB dti-1425 31 249 further further ADJ dti-1425 31 250 antibiotic antibiotic ADJ dti-1425 31 251 resistances.13,16 resistances.13,16 NOUN dti-1425 31 252 furthermore furthermore ADV dti-1425 31 253 , , PUNCT dti-1425 31 254 cons con NOUN dti-1425 31 255 have have VERB dti-1425 31 256 the the DET dti-1425 31 257 intrinsic intrinsic ADJ dti-1425 31 258 ability ability NOUN dti-1425 31 259 to to PART dti-1425 31 260 adhere adhere VERB dti-1425 31 261 to to ADP dti-1425 31 262 foreign foreign ADJ dti-1425 31 263 bodies body NOUN dti-1425 31 264 ( ( PUNCT dti-1425 31 265 eg eg NOUN dti-1425 31 266 , , PUNCT dti-1425 31 267 sternal sternal ADJ dti-1425 31 268 wires wire NOUN dti-1425 31 269 ) ) PUNCT dti-1425 31 270 and and CCONJ dti-1425 31 271 produce produce VERB dti-1425 31 272 a a DET dti-1425 31 273 biofilm biofilm NOUN dti-1425 31 274 , , PUNCT dti-1425 31 275 thus thus ADV dti-1425 31 276 increasing increase VERB dti-1425 31 277 their their PRON dti-1425 31 278 resistance resistance NOUN dti-1425 31 279 to to ADP dti-1425 31 280 antibiotics antibiotic NOUN dti-1425 31 281 and and CCONJ dti-1425 31 282 the the DET dti-1425 31 283 probability probability NOUN dti-1425 31 284 of of ADP dti-1425 31 285 a a DET dti-1425 31 286 chronic chronic ADJ dti-1425 31 287 infection.17,18 infection.17,18 NOUN dti-1425 31 288 advantages advantage NOUN dti-1425 31 289 of of ADP dti-1425 31 290 gentamicin gentamicin ADJ dti-1425 31 291 local local ADJ dti-1425 31 292 delivery delivery NOUN dti-1425 31 293 local local ADJ dti-1425 31 294 administration administration NOUN dti-1425 31 295 of of ADP dti-1425 31 296 antibiotics antibiotic NOUN dti-1425 31 297 such such ADJ dti-1425 31 298 as as ADP dti-1425 31 299 gentamicin gentamicin NOUN dti-1425 31 300 , , PUNCT dti-1425 31 301 tobramycin tobramycin PROPN dti-1425 31 302 , , PUNCT dti-1425 31 303 tetracycline tetracycline NOUN dti-1425 31 304 , , PUNCT dti-1425 31 305 minocycline minocycline PROPN dti-1425 31 306 , , PUNCT dti-1425 31 307 teicoplanin teicoplanin ADJ dti-1425 31 308 , , PUNCT dti-1425 31 309 and and CCONJ dti-1425 31 310 sulbactam sulbactam NOUN dti-1425 31 311 – – PUNCT dti-1425 31 312 cefoperazone cefoperazone NOUN dti-1425 31 313 has have AUX dti-1425 31 314 been be AUX dti-1425 31 315 performed perform VERB dti-1425 31 316 in in ADP dti-1425 31 317 several several ADJ dti-1425 31 318 surgical surgical ADJ dti-1425 31 319 fields.8 fields.8 PROPN dti-1425 31 320 gentamicin gentamicin NOUN dti-1425 31 321 has have AUX dti-1425 31 322 gradually gradually ADV dti-1425 31 323 become become VERB dti-1425 31 324 the the DET dti-1425 31 325 most most ADV dti-1425 31 326 used used ADJ dti-1425 31 327 molecule molecule NOUN dti-1425 31 328 for for ADP dti-1425 31 329 this this DET dti-1425 31 330 purpose purpose NOUN dti-1425 31 331 due due ADP dti-1425 31 332 to to ADP dti-1425 31 333 a a DET dti-1425 31 334 combination combination NOUN dti-1425 31 335 of of ADP dti-1425 31 336 characteristics characteristic NOUN dti-1425 31 337 such such ADJ dti-1425 31 338 as as ADP dti-1425 31 339 broad broad ADJ dti-1425 31 340 spectrum spectrum NOUN dti-1425 31 341 , , PUNCT dti-1425 31 342 low low ADJ dti-1425 31 343 cost cost NOUN dti-1425 31 344 , , PUNCT dti-1425 31 345 and and CCONJ dti-1425 31 346 favorable favorable ADJ dti-1425 31 347 pharmacokinetics pharmacokinetic NOUN dti-1425 31 348 and and CCONJ dti-1425 31 349 pharmacodynamics pharmacodynamic NOUN dti-1425 31 350 when when SCONJ dti-1425 31 351 administered administer VERB dti-1425 31 352 topically.8,19 topically.8,19 ADJ dti-1425 31 353 gentamicin gentamicin NOUN dti-1425 31 354 is be AUX dti-1425 31 355 an an DET dti-1425 31 356 aminoglycoside aminoglycoside ADJ dti-1425 31 357 antibiotic antibiotic NOUN dti-1425 31 358 that that PRON dti-1425 31 359 has have AUX dti-1425 31 360 been be AUX dti-1425 31 361 widely widely ADV dti-1425 31 362 used use VERB dti-1425 31 363 to to PART dti-1425 31 364 treat treat VERB dti-1425 31 365 infections infection NOUN dti-1425 31 366 caused cause VERB dti-1425 31 367 by by ADP dti-1425 31 368 multiresistant multiresistant ADJ dti-1425 31 369 bacteria bacteria NOUN dti-1425 31 370 ( ( PUNCT dti-1425 31 371 fig fig NOUN dti-1425 31 372 . . PUNCT dti-1425 32 1 1 1 NUM dti-1425 32 2 ) ) PUNCT dti-1425 32 3 . . PUNCT dti-1425 33 1 although although SCONJ dti-1425 33 2 its its PRON dti-1425 33 3 spectrum spectrum NOUN dti-1425 33 4 is be AUX dti-1425 33 5 mainly mainly ADV dti-1425 33 6 directed direct VERB dti-1425 33 7 toward toward ADP dti-1425 33 8 gram gram NOUN dti-1425 33 9 - - PUNCT dti-1425 33 10 negative negative ADJ dti-1425 33 11 species specie NOUN dti-1425 33 12 , , PUNCT dti-1425 33 13 gentamicin gentamicin PROPN dti-1425 33 14 is be AUX dti-1425 33 15 also also ADV dti-1425 33 16 effective effective ADJ dti-1425 33 17 against against ADP dti-1425 33 18 several several ADJ dti-1425 33 19 gram gram NOUN dti-1425 33 20 - - PUNCT dti-1425 33 21 positive positive ADJ dti-1425 33 22 strains.19 strains.19 NOUN dti-1425 33 23 furthermore furthermore ADV dti-1425 33 24 , , PUNCT dti-1425 33 25 gentamicin gentamicin PROPN dti-1425 33 26 also also ADV dti-1425 33 27 shows show VERB dti-1425 33 28 a a DET dti-1425 33 29 synergy synergy NOUN dti-1425 33 30 with with ADP dti-1425 33 31 beta beta NOUN dti-1425 33 32 - - PUNCT dti-1425 33 33 lactam lactam NOUN dti-1425 33 34 antibiotics antibiotic NOUN dti-1425 33 35 , , PUNCT dti-1425 33 36 especially especially ADV dti-1425 33 37 against against ADP dti-1425 33 38 gram gram NOUN dti-1425 33 39 - - PUNCT dti-1425 33 40 positive positive ADJ dti-1425 33 41 species specie NOUN dti-1425 33 42 such such ADJ dti-1425 33 43 as as ADP dti-1425 33 44 s. s. PROPN dti-1425 33 45 aureus aureus PROPN dti-1425 33 46 and and CCONJ dti-1425 33 47 cons.16 cons.16 PROPN dti-1425 33 48 nevertheless nevertheless ADV dti-1425 33 49 , , PUNCT dti-1425 33 50 the the DET dti-1425 33 51 principal principal ADJ dti-1425 33 52 factor factor NOUN dti-1425 33 53 limiting limit VERB dti-1425 33 54 its its PRON dti-1425 33 55 systemic systemic ADJ dti-1425 33 56 use use NOUN dti-1425 33 57 is be AUX dti-1425 33 58 represented represent VERB dti-1425 33 59 by by ADP dti-1425 33 60 its its PRON dti-1425 33 61 intrinsic intrinsic ADJ dti-1425 33 62 toxicity toxicity NOUN dti-1425 33 63 ; ; PUNCT dti-1425 33 64 when when SCONJ dti-1425 33 65 administered administer VERB dti-1425 33 66 intravenously intravenously ADV dti-1425 33 67 or or CCONJ dti-1425 33 68 intramuscularly intramuscularly ADV dti-1425 33 69 , , PUNCT dti-1425 33 70 gentamicin gentamicin PROPN dti-1425 33 71 accumulates accumulate VERB dti-1425 33 72 into into ADP dti-1425 33 73 renal renal ADJ dti-1425 33 74 cortex cortex NOUN dti-1425 33 75 and and CCONJ dti-1425 33 76 into into ADP dti-1425 33 77 endolymph endolymph NOUN dti-1425 33 78 and and CCONJ dti-1425 33 79 perilymph perilymph NOUN dti-1425 33 80 of of ADP dti-1425 33 81 the the DET dti-1425 33 82 inner inner ADJ dti-1425 33 83 ear ear NOUN dti-1425 33 84 , , PUNCT dti-1425 33 85 causing cause VERB dti-1425 33 86 kidney kidney NOUN dti-1425 33 87 injury injury NOUN dti-1425 33 88 and and CCONJ dti-1425 33 89 hearing hear VERB dti-1425 33 90 loss.20 loss.20 NOUN dti-1425 33 91 these these DET dti-1425 33 92 drawbacks drawback NOUN dti-1425 33 93 can can AUX dti-1425 33 94 be be AUX dti-1425 33 95 partially partially ADV dti-1425 33 96 eluded elude VERB dti-1425 33 97 by by ADP dti-1425 33 98 administering administer VERB dti-1425 33 99 gentamicin gentamicin NOUN dti-1425 33 100 locally locally ADV dti-1425 33 101 , , PUNCT dti-1425 33 102 reducing reduce VERB dti-1425 33 103 the the DET dti-1425 33 104 systemic systemic ADJ dti-1425 33 105 toxicity toxicity NOUN dti-1425 33 106 . . PUNCT dti-1425 34 1 kidney kidney NOUN dti-1425 34 2 and and CCONJ dti-1425 34 3 inner inner ADJ dti-1425 34 4 ear ear NOUN dti-1425 34 5 accumulations accumulation NOUN dti-1425 34 6 seem seem VERB dti-1425 34 7 to to PART dti-1425 34 8 appear appear VERB dti-1425 34 9 when when SCONJ dti-1425 34 10 gentamicin gentamicin NOUN dti-1425 34 11 serum serum NOUN dti-1425 34 12 concentration concentration NOUN dti-1425 34 13 exceeds exceed VERB dti-1425 34 14 10–12 10–12 NUM dti-1425 34 15     SPACE dti-1425 34 16 mg mg PROPN dti-1425 34 17 / / SYM dti-1425 34 18 l l NOUN dti-1425 34 19 , , PUNCT dti-1425 34 20 although although SCONJ dti-1425 34 21 a a DET dti-1425 34 22 precise precise ADJ dti-1425 34 23 cutoff cutoff NOUN dti-1425 34 24 has have AUX dti-1425 34 25 not not PART dti-1425 34 26 been be AUX dti-1425 34 27 established.8,21 established.8,21 NOUN dti-1425 34 28 interestingly interestingly ADV dti-1425 34 29 , , PUNCT dti-1425 34 30 it it PRON dti-1425 34 31 has have AUX dti-1425 34 32 been be AUX dti-1425 34 33 observed observe VERB dti-1425 34 34 that that SCONJ dti-1425 34 35 , , PUNCT dti-1425 34 36 after after ADP dti-1425 34 37 local local ADJ dti-1425 34 38 administration administration NOUN dti-1425 34 39 in in ADP dti-1425 34 40 the the DET dti-1425 34 41 sternal sternal ADJ dti-1425 34 42 region region NOUN dti-1425 34 43 , , PUNCT dti-1425 34 44 the the DET dti-1425 34 45 drug drug NOUN dti-1425 34 46 serum serum NOUN dti-1425 34 47 concentration concentration NOUN dti-1425 34 48 does do AUX dti-1425 34 49 not not PART dti-1425 34 50 exceed exceed VERB dti-1425 34 51 1 1 NUM dti-1425 34 52     SPACE dti-1425 34 53 mg mg PROPN dti-1425 34 54 / / SYM dti-1425 34 55 l l NOUN dti-1425 34 56 , , PUNCT dti-1425 34 57 while while SCONJ dti-1425 34 58 mediastinal mediastinal ADJ dti-1425 34 59 fluid fluid ADJ dti-1425 34 60 concentration concentration NOUN dti-1425 34 61 remains remain VERB dti-1425 34 62 above above ADP dti-1425 34 63 300 300 NUM dti-1425 34 64     SPACE dti-1425 34 65 mg mg PROPN dti-1425 34 66 / / SYM dti-1425 34 67 l l NOUN dti-1425 34 68 for for ADP dti-1425 34 69 36 36 NUM dti-1425 34 70 hours.21 hours.21 NOUN dti-1425 34 71 moreover moreover ADV dti-1425 34 72 , , PUNCT dti-1425 34 73 gentamicin gentamicin NOUN dti-1425 34 74 exhibits exhibit VERB dti-1425 34 75 a a DET dti-1425 34 76 concentration concentration NOUN dti-1425 34 77 - - PUNCT dti-1425 34 78 dependent dependent ADJ dti-1425 34 79 effect effect NOUN dti-1425 34 80 , , PUNCT dti-1425 34 81 especially especially ADV dti-1425 34 82 against against ADP dti-1425 34 83 gram gram NOUN dti-1425 34 84 - - PUNCT dti-1425 34 85 negative negative ADJ dti-1425 34 86 rods rod NOUN dti-1425 34 87 : : PUNCT dti-1425 34 88 this this PRON dti-1425 34 89 means mean VERB dti-1425 34 90 that that SCONJ dti-1425 34 91 a a DET dti-1425 34 92 high high ADJ dti-1425 34 93 concentration concentration NOUN dti-1425 34 94 of of ADP dti-1425 34 95 the the DET dti-1425 34 96 drug drug NOUN dti-1425 34 97 circumscribed circumscribe VERB dti-1425 34 98 to to ADP dti-1425 34 99 the the DET dti-1425 34 100 surgical surgical ADJ dti-1425 34 101 site site NOUN dti-1425 34 102 can can AUX dti-1425 34 103 lead lead VERB dti-1425 34 104 to to ADP dti-1425 34 105 a a DET dti-1425 34 106 bactericidal bactericidal ADJ dti-1425 34 107 effect effect NOUN dti-1425 34 108 not not PART dti-1425 34 109 only only ADV dti-1425 34 110 toward toward ADP dti-1425 34 111 sensitive sensitive ADJ dti-1425 34 112 bacteria bacteria NOUN dti-1425 34 113 but but CCONJ dti-1425 34 114 also also ADV dti-1425 34 115 toward toward ADP dti-1425 34 116 poorly poorly ADV dti-1425 34 117 sensitive sensitive ADJ dti-1425 34 118 or or CCONJ dti-1425 34 119 even even ADV dti-1425 34 120 resistant resistant ADJ dti-1425 34 121 ones;20 ones;20 NOUN dti-1425 34 122 an an DET dti-1425 34 123 acute acute ADJ dti-1425 34 124 peak peak NOUN dti-1425 34 125 concentration concentration NOUN dti-1425 34 126 in in ADP dti-1425 34 127 the the DET dti-1425 34 128 surgical surgical ADJ dti-1425 34 129 site site NOUN dti-1425 34 130 , , PUNCT dti-1425 34 131 combined combine VERB dti-1425 34 132 with with ADP dti-1425 34 133 a a DET dti-1425 34 134 low low ADJ dti-1425 34 135 serum serum NOUN dti-1425 34 136 level level NOUN dti-1425 34 137 of of ADP dti-1425 34 138 the the DET dti-1425 34 139 drug drug NOUN dti-1425 34 140 , , PUNCT dti-1425 34 141 is be AUX dti-1425 34 142 protective protective ADJ dti-1425 34 143 against against ADP dti-1425 34 144 the the DET dti-1425 34 145 selection selection NOUN dti-1425 34 146 of of ADP dti-1425 34 147 resistant resistant ADJ dti-1425 34 148 bacteria bacteria NOUN dti-1425 34 149 ; ; PUNCT dti-1425 34 150 in in ADP dti-1425 34 151 fact fact NOUN dti-1425 34 152 , , PUNCT dti-1425 34 153 prolonged prolong VERB dti-1425 34 154 high high ADJ dti-1425 34 155 serum serum NOUN dti-1425 34 156 concentrations concentration NOUN dti-1425 34 157 promote promote VERB dti-1425 34 158 the the DET dti-1425 34 159 so so ADV dti-1425 34 160 - - PUNCT dti-1425 34 161 called call VERB dti-1425 34 162 adaptive adaptive ADJ dti-1425 34 163 resistance resistance NOUN dti-1425 34 164 to to ADP dti-1425 34 165 gentamicin.20 gentamicin.20 PROPN dti-1425 34 166 pharmacokinetics pharmacokinetic NOUN dti-1425 34 167 of of ADP dti-1425 34 168 gics gic NOUN dti-1425 34 169 surgical surgical ADJ dti-1425 34 170 implants implant NOUN dti-1425 34 171 impregnated impregnate VERB dti-1425 34 172 with with ADP dti-1425 34 173 gentamicin gentamicin NOUN dti-1425 34 174 started start VERB dti-1425 34 175 to to PART dti-1425 34 176 be be AUX dti-1425 34 177 used use VERB dti-1425 34 178 in in ADP dti-1425 34 179 the the DET dti-1425 34 180 1970s 1970 NOUN dti-1425 34 181 , , PUNCT dti-1425 34 182 primarily primarily ADV dti-1425 34 183 in in ADP dti-1425 34 184 orthopedic orthopedic ADJ dti-1425 34 185 surgery surgery NOUN dti-1425 34 186 , , PUNCT dti-1425 34 187 aiming aim VERB dti-1425 34 188 to to PART dti-1425 34 189 treat treat VERB dti-1425 34 190 or or CCONJ dti-1425 34 191 prevent prevent VERB dti-1425 34 192 prosthetic prosthetic ADJ dti-1425 34 193 infections infection NOUN dti-1425 34 194 . . PUNCT dti-1425 35 1 the the DET dti-1425 35 2 first first ADJ dti-1425 35 3 devices device NOUN dti-1425 35 4 had have VERB dti-1425 35 5 the the DET dti-1425 35 6 disadvantage disadvantage NOUN dti-1425 35 7 that that SCONJ dti-1425 35 8 they they PRON dti-1425 35 9 were be AUX dti-1425 35 10 not not PART dti-1425 35 11 made make VERB dti-1425 35 12 of of ADP dti-1425 35 13 reabsorbable reabsorbable ADJ dti-1425 35 14 materials material NOUN dti-1425 35 15 ; ; PUNCT dti-1425 35 16 hence hence ADV dti-1425 35 17 , , PUNCT dti-1425 35 18 they they PRON dti-1425 35 19 had have VERB dti-1425 35 20 to to PART dti-1425 35 21 be be AUX dti-1425 35 22 surgically surgically ADV dti-1425 35 23 removed remove VERB dti-1425 35 24 once once SCONJ dti-1425 35 25 the the DET dti-1425 35 26 infection infection NOUN dti-1425 35 27 had have AUX dti-1425 35 28 been be AUX dti-1425 35 29 treated.22 treated.22 NUM dti-1425 35 30 as as ADP dti-1425 35 31 a a DET dti-1425 35 32 consequence consequence NOUN dti-1425 35 33 , , PUNCT dti-1425 35 34 biodegradable biodegradable ADJ dti-1425 35 35 polymers polymer NOUN dti-1425 35 36 such such ADJ dti-1425 35 37 as as ADP dti-1425 35 38 polylactic polylactic ADJ dti-1425 35 39 acid acid NOUN dti-1425 35 40 , , PUNCT dti-1425 35 41 polyglycolic polyglycolic NOUN dti-1425 35 42 - - PUNCT dti-1425 35 43 polylactic polylactic ADJ dti-1425 35 44 acid acid NOUN dti-1425 35 45 , , PUNCT dti-1425 35 46 poly(ortho poly(ortho PROPN dti-1425 35 47 esters ester NOUN dti-1425 35 48 ) ) PUNCT dti-1425 35 49 , , PUNCT dti-1425 35 50 and and CCONJ dti-1425 35 51 polyhydroxybutyrate polyhydroxybutyrate VERB dti-1425 35 52 - - PUNCT dti-1425 35 53 co co NOUN dti-1425 35 54 - - ADJ dti-1425 35 55 hydroxyvalerate hydroxyvalerate NOUN dti-1425 35 56 were be AUX dti-1425 35 57 developed develop VERB dti-1425 35 58 to to PART dti-1425 35 59 carry carry VERB dti-1425 35 60 antibiotic antibiotic ADJ dti-1425 35 61 drugs drug NOUN dti-1425 35 62 to to ADP dti-1425 35 63 the the DET dti-1425 35 64 surgical surgical ADJ dti-1425 35 65 site.23,24 site.23,24 NOUN dti-1425 35 66 finally finally ADV dti-1425 35 67 , , PUNCT dti-1425 35 68 since since SCONJ dti-1425 35 69 the the DET dti-1425 35 70 1980s 1980s NUM dti-1425 35 71 , , PUNCT dti-1425 35 72 collagen collagen NOUN dti-1425 35 73 implants implant NOUN dti-1425 35 74 began begin VERB dti-1425 35 75 to to PART dti-1425 35 76 be be AUX dti-1425 35 77 used use VERB dti-1425 35 78 in in ADP dti-1425 35 79 several several ADJ dti-1425 35 80 surgical surgical ADJ dti-1425 35 81 specialties specialty NOUN dti-1425 35 82 for for ADP dti-1425 35 83 local local ADJ dti-1425 35 84 antibiotic antibiotic ADJ dti-1425 35 85 delivery delivery NOUN dti-1425 35 86 , , PUNCT dti-1425 35 87 mainly mainly ADV dti-1425 35 88 due due ADP dti-1425 35 89 to to ADP dti-1425 35 90 collagen collagen NOUN dti-1425 35 91 biocompatibility biocompatibility NOUN dti-1425 35 92 and and CCONJ dti-1425 35 93 pharmacokinetic pharmacokinetic ADJ dti-1425 35 94 versatility.23,24 versatility.23,24 NOUN dti-1425 35 95 regarding regard VERB dti-1425 35 96 pharmacokinetics pharmacokinetic NOUN dti-1425 35 97 , , PUNCT dti-1425 35 98 collagen collagen NOUN dti-1425 35 99 is be AUX dti-1425 35 100 a a DET dti-1425 35 101 unique unique ADJ dti-1425 35 102 polymer polymer NOUN dti-1425 35 103 because because SCONJ dti-1425 35 104 it it PRON dti-1425 35 105 has have VERB dti-1425 35 106 a a DET dti-1425 35 107 complex complex ADJ dti-1425 35 108 , , PUNCT dti-1425 35 109 well well ADV dti-1425 35 110 - - PUNCT dti-1425 35 111 known know VERB dti-1425 35 112 three three NUM dti-1425 35 113 - - PUNCT dti-1425 35 114 dimensional dimensional ADJ dti-1425 35 115 structure structure NOUN dti-1425 35 116 with with ADP dti-1425 35 117 different different ADJ dti-1425 35 118 hierarchical hierarchical ADJ dti-1425 35 119 levels level NOUN dti-1425 35 120 : : PUNCT dti-1425 35 121 primary primary ADJ dti-1425 35 122 , , PUNCT dti-1425 35 123 secondary secondary ADJ dti-1425 35 124 , , PUNCT dti-1425 35 125 tertiary tertiary ADJ dti-1425 35 126 , , PUNCT dti-1425 35 127 and and CCONJ dti-1425 35 128 quaternary.25 quaternary.25 VERB dti-1425 35 129 the the DET dti-1425 35 130 physiochemical physiochemical ADJ dti-1425 35 131 characteristics characteristic NOUN dti-1425 35 132 table table NOUN dti-1425 35 133 1 1 NUM dti-1425 35 134 . . PUNCT dti-1425 36 1 microbiology microbiology NOUN dti-1425 36 2 of of ADP dti-1425 36 3 swis swis PROPN dti-1425 36 4 . . PUNCT dti-1425 37 1 microorganism microorganism NOUN dti-1425 37 2 frequency frequency NOUN dti-1425 37 3 gram gram NOUN dti-1425 37 4 - - PUNCT dti-1425 37 5 positive positive ADJ dti-1425 37 6 cocci cocci NOUN dti-1425 37 7 60–80 60–80 NUM dti-1425 37 8 % % NOUN dti-1425 37 9 staphylococcus staphylococcus NOUN dti-1425 37 10 aureus aureus NOUN dti-1425 37 11 40–45 40–45 NUM dti-1425 37 12 % % NOUN dti-1425 37 13 coagulase coagulase ADJ dti-1425 37 14 - - PUNCT dti-1425 37 15 negative negative ADJ dti-1425 37 16 staphylococcus staphylococcus NOUN dti-1425 37 17 20–35 20–35 NUM dti-1425 37 18 % % NOUN dti-1425 37 19 gram gram NOUN dti-1425 37 20 - - PUNCT dti-1425 37 21 negative negative ADJ dti-1425 37 22 rods rod NOUN dti-1425 37 23 20–40 20–40 NUM dti-1425 37 24 % % NOUN dti-1425 37 25 enterobacter enterobacter ADJ dti-1425 37 26 spp spp NOUN dti-1425 37 27 10 10 NUM dti-1425 37 28 % % NOUN dti-1425 37 29 pseudomonas pseudomona NOUN dti-1425 37 30 spp spp NOUN dti-1425 37 31 2–10 2–10 NOUN dti-1425 37 32 % % NOUN dti-1425 37 33 klebsiella klebsiella PROPN dti-1425 37 34 spp spp NOUN dti-1425 37 35 3–8 3–8 NUM dti-1425 37 36 % % NOUN dti-1425 37 37 escherichia escherichia NOUN dti-1425 37 38 coli coli NOUN dti-1425 37 39 5 5 NUM dti-1425 37 40 % % NOUN dti-1425 37 41 proteus proteus NOUN dti-1425 37 42 spp spp NOUN dti-1425 37 43 2–3 2–3 NOUN dti-1425 37 44 % % NOUN dti-1425 37 45 fungi fungus NOUN dti-1425 37 46 5 5 NUM dti-1425 37 47 % % NOUN dti-1425 37 48 polymicrobial polymicrobial ADJ dti-1425 37 49 10–40 10–40 NUM dti-1425 37 50 % % NOUN dti-1425 37 51 note note NOUN dti-1425 37 52 : : PUNCT dti-1425 37 53 adapted adapt VERB dti-1425 37 54 from from ADP dti-1425 37 55 refs ref NOUN dti-1425 37 56 . . PUNCT dti-1425 38 1 1,14,15 1,14,15 NUM dti-1425 38 2 . . PUNCT dti-1425 38 3 figure figure NOUN dti-1425 38 4 1 1 NUM dti-1425 38 5 . . PUNCT dti-1425 38 6 chemical chemical ADJ dti-1425 38 7 structure structure NOUN dti-1425 38 8 of of ADP dti-1425 38 9 gentamicin gentamicin PROPN dti-1425 38 10 . . PUNCT dti-1425 39 1 notes note NOUN dti-1425 39 2 : : PUNCT dti-1425 39 3 atoms atom NOUN dti-1425 39 4 are be AUX dti-1425 39 5 represented represent VERB dti-1425 39 6 as as ADP dti-1425 39 7 spheres sphere NOUN dti-1425 39 8 with with ADP dti-1425 39 9 conventional conventional ADJ dti-1425 39 10 color color NOUN dti-1425 39 11 coding coding NOUN dti-1425 39 12 : : PUNCT dti-1425 39 13 white white PROPN dti-1425 39 14 represents represent VERB dti-1425 39 15 hydrogen hydrogen NOUN dti-1425 39 16 , , PUNCT dti-1425 39 17 gray gray ADJ dti-1425 39 18 represents represent VERB dti-1425 39 19 carbon carbon NOUN dti-1425 39 20 , , PUNCT dti-1425 39 21 blue blue NOUN dti-1425 39 22 represents represent VERB dti-1425 39 23 nitrogen nitrogen NOUN dti-1425 39 24 , , PUNCT dti-1425 39 25 and and CCONJ dti-1425 39 26 red red NOUN dti-1425 39 27 represents represent VERB dti-1425 39 28 oxygen oxygen NOUN dti-1425 39 29 . . PUNCT dti-1425 40 1 http://www.la-press.com http://www.la-press.com X dti-1425 41 1 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1425 41 2 effectiveness effectiveness NOUN dti-1425 41 3 of of ADP dti-1425 41 4 gentamicin gentamicin NOUN dti-1425 41 5 - - PUNCT dti-1425 41 6 impregnated impregnate VERB dti-1425 41 7 collagen collagen NOUN dti-1425 41 8 sponge sponge NOUN dti-1425 41 9 11drug 11drug NUM dti-1425 42 1 target target VERB dti-1425 42 2 insights insight NOUN dti-1425 42 3 2016:10(s1 2016:10(s1 NUM dti-1425 42 4 ) ) PUNCT dti-1425 42 5 of of ADP dti-1425 42 6 the the DET dti-1425 42 7 final final ADJ dti-1425 42 8 polymer polymer NOUN dti-1425 42 9 can can AUX dti-1425 42 10 be be AUX dti-1425 42 11 modified modify VERB dti-1425 42 12 by by ADP dti-1425 42 13 intervening intervene VERB dti-1425 42 14 on on ADP dti-1425 42 15 the the DET dti-1425 42 16 molecular molecular ADJ dti-1425 42 17 structure structure NOUN dti-1425 42 18 ( ( PUNCT dti-1425 42 19 eg eg NOUN dti-1425 42 20 , , PUNCT dti-1425 42 21 intraand intraand X dti-1425 42 22 intermolecular intermolecular ADJ dti-1425 42 23 cross cross NOUN dti-1425 42 24 - - NOUN dti-1425 42 25 links link NOUN dti-1425 42 26 ) ) PUNCT dti-1425 42 27 as as ADV dti-1425 42 28 well well ADV dti-1425 42 29 as as ADP dti-1425 42 30 linking link VERB dti-1425 42 31 collagen collagen NOUN dti-1425 42 32 with with ADP dti-1425 42 33 other other ADJ dti-1425 42 34 polymers polymer NOUN dti-1425 42 35 to to PART dti-1425 42 36 obtain obtain VERB dti-1425 42 37 different different ADJ dti-1425 42 38 drug drug NOUN dti-1425 42 39 - - PUNCT dti-1425 42 40 releasing release VERB dti-1425 42 41 temporal temporal ADJ dti-1425 42 42 curves curve NOUN dti-1425 42 43 . . PUNCT dti-1425 43 1 hence hence ADV dti-1425 43 2 , , PUNCT dti-1425 43 3 when when SCONJ dti-1425 43 4 collagen collagen NOUN dti-1425 43 5 is be AUX dti-1425 43 6 used use VERB dti-1425 43 7 as as ADP dti-1425 43 8 a a DET dti-1425 43 9 carrier carrier NOUN dti-1425 43 10 for for ADP dti-1425 43 11 a a DET dti-1425 43 12 drug drug NOUN dti-1425 43 13 , , PUNCT dti-1425 43 14 any any DET dti-1425 43 15 structural structural ADJ dti-1425 43 16 modification modification NOUN dti-1425 43 17 can can AUX dti-1425 43 18 lead lead VERB dti-1425 43 19 to to ADP dti-1425 43 20 different different ADJ dti-1425 43 21 pharmacokinetic pharmacokinetic ADJ dti-1425 43 22 profiles.8,26,27 profiles.8,26,27 ADJ dti-1425 43 23 collagen collagen NOUN dti-1425 43 24 biocompatibility biocompatibility NOUN dti-1425 43 25 and and CCONJ dti-1425 43 26 absorbability absorbability NOUN dti-1425 43 27 represent represent VERB dti-1425 43 28 essential essential ADJ dti-1425 43 29 characteristics characteristic NOUN dti-1425 43 30 with with ADP dti-1425 43 31 respect respect NOUN dti-1425 43 32 to to ADP dti-1425 43 33 infection infection NOUN dti-1425 43 34 prevention prevention NOUN dti-1425 43 35 or or CCONJ dti-1425 43 36 treatment treatment NOUN dti-1425 43 37 , , PUNCT dti-1425 43 38 because because SCONJ dti-1425 43 39 they they PRON dti-1425 43 40 allow allow VERB dti-1425 43 41 to to PART dti-1425 43 42 avoid avoid VERB dti-1425 43 43 a a DET dti-1425 43 44 further further ADJ dti-1425 43 45 surgical surgical ADJ dti-1425 43 46 procedure procedure NOUN dti-1425 43 47 ( ( PUNCT dti-1425 43 48 which which PRON dti-1425 43 49 could could AUX dti-1425 43 50 be be AUX dti-1425 43 51 as as ADV dti-1425 43 52 well well ADV dti-1425 43 53 complicated complicated ADJ dti-1425 43 54 by by ADP dti-1425 43 55 infection infection NOUN dti-1425 43 56 ) ) PUNCT dti-1425 43 57 to to PART dti-1425 43 58 remove remove VERB dti-1425 43 59 the the DET dti-1425 43 60 drug drug NOUN dti-1425 43 61 - - PUNCT dti-1425 43 62 carrying carry VERB dti-1425 43 63 device device NOUN dti-1425 43 64 . . PUNCT dti-1425 44 1 gentamicin gentamicin NOUN dti-1425 44 2 - - PUNCT dti-1425 44 3 impregnated impregnate VERB dti-1425 44 4 collagen collagen NOUN dti-1425 44 5 sponges sponge NOUN dti-1425 44 6 ( ( PUNCT dti-1425 44 7 gicss gicss PROPN dti-1425 44 8 ) ) PUNCT dti-1425 44 9 can can AUX dti-1425 44 10 be be AUX dti-1425 44 11 inserted insert VERB dti-1425 44 12 in in ADP dti-1425 44 13 three three NUM dti-1425 44 14 different different ADJ dti-1425 44 15 regions region NOUN dti-1425 44 16 during during ADP dti-1425 44 17 sternal sternal ADJ dti-1425 44 18 closure closure NOUN dti-1425 44 19 , , PUNCT dti-1425 44 20 depending depend VERB dti-1425 44 21 on on ADP dti-1425 44 22 the the DET dti-1425 44 23 desired desire VERB dti-1425 44 24 primary primary ADJ dti-1425 44 25 site site NOUN dti-1425 44 26 of of ADP dti-1425 44 27 action action NOUN dti-1425 44 28 : : PUNCT dti-1425 44 29 – – PUNCT dti-1425 44 30 behind behind ADP dti-1425 44 31 the the DET dti-1425 44 32 posterior posterior ADJ dti-1425 44 33 surface surface NOUN dti-1425 44 34 of of ADP dti-1425 44 35 the the DET dti-1425 44 36 sternum sternum NOUN dti-1425 44 37 , , PUNCT dti-1425 44 38 between between ADP dti-1425 44 39 the the DET dti-1425 44 40 bone bone NOUN dti-1425 44 41 and and CCONJ dti-1425 44 42 the the DET dti-1425 44 43 sternal sternal ADJ dti-1425 44 44 wires wire NOUN dti-1425 44 45 ; ; PUNCT dti-1425 44 46 – – PUNCT dti-1425 44 47 between between ADP dti-1425 44 48 sternal sternal ADJ dti-1425 44 49 halves half NOUN dti-1425 44 50 ; ; PUNCT dti-1425 44 51 and and CCONJ dti-1425 44 52 – – PUNCT dti-1425 44 53 on on ADP dti-1425 44 54 the the DET dti-1425 44 55 anterior anterior ADJ dti-1425 44 56 surface surface NOUN dti-1425 44 57 of of ADP dti-1425 44 58 the the DET dti-1425 44 59 sternum sternum NOUN dti-1425 44 60 , , PUNCT dti-1425 44 61 under under ADP dti-1425 44 62 the the DET dti-1425 44 63 muscular muscular ADJ dti-1425 44 64 fascia fascia NOUN dti-1425 44 65 . . PUNCT dti-1425 45 1 every every DET dti-1425 45 2 different different ADJ dti-1425 45 3 position position NOUN dti-1425 45 4 of of ADP dti-1425 45 5 the the DET dti-1425 45 6 gics gic NOUN dti-1425 45 7 corresponds correspond VERB dti-1425 45 8 to to ADP dti-1425 45 9 a a DET dti-1425 45 10 slightly slightly ADV dti-1425 45 11 different different ADJ dti-1425 45 12 spatial spatial ADJ dti-1425 45 13 distribution distribution NOUN dti-1425 45 14 of of ADP dti-1425 45 15 gentamicin gentamicin NOUN dti-1425 45 16 , , PUNCT dti-1425 45 17 according accord VERB dti-1425 45 18 to to ADP dti-1425 45 19 the the DET dti-1425 45 20 closest close ADJ dti-1425 45 21 sternal sternal ADJ dti-1425 45 22 region.28,29 region.28,29 NOUN dti-1425 45 23 for for ADP dti-1425 45 24 instance instance NOUN dti-1425 45 25 , , PUNCT dti-1425 45 26 when when SCONJ dti-1425 45 27 a a DET dti-1425 45 28 gics gic NOUN dti-1425 45 29 was be AUX dti-1425 45 30 placed place VERB dti-1425 45 31 posteriorly posteriorly ADV dti-1425 45 32 to to ADP dti-1425 45 33 the the DET dti-1425 45 34 sternum sternum NOUN dti-1425 45 35 , , PUNCT dti-1425 45 36 its its PRON dti-1425 45 37 effect effect NOUN dti-1425 45 38 was be AUX dti-1425 45 39 more more ADV dti-1425 45 40 evident evident ADJ dti-1425 45 41 in in ADP dti-1425 45 42 preventing prevent VERB dti-1425 45 43 dswi dswi NOUN dti-1425 45 44 rather rather ADV dti-1425 45 45 than than ADP dti-1425 45 46 sswi.30 sswi.30 NOUN dti-1425 45 47 one one NUM dti-1425 45 48 or or CCONJ dti-1425 45 49 two two NUM dti-1425 45 50 gicss gicss NOUN dti-1425 45 51 per per ADP dti-1425 45 52 patient patient NOUN dti-1425 45 53 , , PUNCT dti-1425 45 54 corresponding correspond VERB dti-1425 45 55 to to ADP dti-1425 45 56 130 130 NUM dti-1425 45 57 and and CCONJ dti-1425 45 58 260 260 NUM dti-1425 45 59     SPACE dti-1425 45 60 mg mg PROPN dti-1425 45 61 of of ADP dti-1425 45 62 gentamicin gentamicin NOUN dti-1425 45 63 , , PUNCT dti-1425 45 64 respectively respectively ADV dti-1425 45 65 , , PUNCT dti-1425 45 66 were be AUX dti-1425 45 67 used use VERB dti-1425 45 68 in in ADP dti-1425 45 69 most most ADJ dti-1425 45 70 of of ADP dti-1425 45 71 the the DET dti-1425 45 72 reviewed review VERB dti-1425 45 73 studies study NOUN dti-1425 45 74 , , PUNCT dti-1425 45 75 with with ADP dti-1425 45 76 various various ADJ dti-1425 45 77 combinations combination NOUN dti-1425 45 78 of of ADP dti-1425 45 79 the the DET dti-1425 45 80 abovementioned abovementioned ADJ dti-1425 45 81 positions position NOUN dti-1425 45 82 . . PUNCT dti-1425 46 1 there there PRON dti-1425 46 2 is be VERB dti-1425 46 3 some some DET dti-1425 46 4 evidence evidence NOUN dti-1425 46 5 that that SCONJ dti-1425 46 6 collagen collagen NOUN dti-1425 46 7 sponges sponge NOUN dti-1425 46 8 should should AUX dti-1425 46 9 not not PART dti-1425 46 10 be be AUX dti-1425 46 11 soaked soak VERB dti-1425 46 12 in in ADP dti-1425 46 13 saline saline ADJ dti-1425 46 14 solution solution NOUN dti-1425 46 15 prior prior ADV dti-1425 46 16 to to ADP dti-1425 46 17 use.31,32 use.31,32 PROPN dti-1425 46 18 bennett bennett PROPN dti-1425 46 19 - - PUNCT dti-1425 46 20 guerrero guerrero PROPN dti-1425 46 21 et et PROPN dti-1425 46 22 al al PROPN dti-1425 46 23 conducted conduct VERB dti-1425 46 24 a a DET dti-1425 46 25 multicenter multicenter NOUN dti-1425 46 26 randomized randomize VERB dti-1425 46 27 double double ADJ dti-1425 46 28 - - PUNCT dti-1425 46 29 blind blind ADJ dti-1425 46 30 trial trial NOUN dti-1425 46 31 comparing compare VERB dti-1425 46 32 high high ADJ dti-1425 46 33 - - PUNCT dti-1425 46 34 risk risk NOUN dti-1425 46 35 cardiac cardiac ADJ dti-1425 46 36 surgical surgical ADJ dti-1425 46 37 patients patient NOUN dti-1425 46 38 receiving receive VERB dti-1425 46 39 a a DET dti-1425 46 40 gics gic NOUN dti-1425 46 41 with with ADP dti-1425 46 42 patients patient NOUN dti-1425 46 43 receiving receive VERB dti-1425 46 44 a a DET dti-1425 46 45 standard standard ADJ dti-1425 46 46 sternal sternal ADJ dti-1425 46 47 closure closure NOUN dti-1425 46 48 . . PUNCT dti-1425 47 1 the the DET dti-1425 47 2 authors author NOUN dti-1425 47 3 found find VERB dti-1425 47 4 no no DET dti-1425 47 5 advantages advantage NOUN dti-1425 47 6 for for ADP dti-1425 47 7 the the DET dti-1425 47 8 study study NOUN dti-1425 47 9 group group NOUN dti-1425 47 10 over over ADP dti-1425 47 11 the the DET dti-1425 47 12 control control NOUN dti-1425 47 13 group group NOUN dti-1425 47 14 regarding regard VERB dti-1425 47 15 the the DET dti-1425 47 16 incidence incidence NOUN dti-1425 47 17 of of ADP dti-1425 47 18 swi swi PROPN dti-1425 47 19 up up ADP dti-1425 47 20 to to PART dti-1425 47 21 90 90 NUM dti-1425 47 22 days day NOUN dti-1425 47 23 after after ADP dti-1425 47 24 surgery surgery NOUN dti-1425 47 25 . . PUNCT dti-1425 48 1 the the DET dti-1425 48 2 gics gic NOUN dti-1425 48 3 were be AUX dti-1425 48 4 soaked soak VERB dti-1425 48 5 in in ADP dti-1425 48 6 saline saline NOUN dti-1425 48 7 as as ADP dti-1425 48 8 per per ADP dti-1425 48 9 the the DET dti-1425 48 10 study study NOUN dti-1425 48 11 protocol protocol NOUN dti-1425 48 12 , , PUNCT dti-1425 48 13 and and CCONJ dti-1425 48 14 the the DET dti-1425 48 15 authors author NOUN dti-1425 48 16 have have AUX dti-1425 48 17 been be AUX dti-1425 48 18 criticized criticize VERB dti-1425 48 19 due due ADP dti-1425 48 20 to to ADP dti-1425 48 21 this this DET dti-1425 48 22 maneuver.31 maneuver.31 NOUN dti-1425 48 23 gentamicin gentamicin VERB dti-1425 48 24 is be AUX dti-1425 48 25 a a DET dti-1425 48 26 highly highly ADV dti-1425 48 27 water water NOUN dti-1425 48 28 - - PUNCT dti-1425 48 29 soluble soluble ADJ dti-1425 48 30 molecule molecule NOUN dti-1425 48 31 , , PUNCT dti-1425 48 32 and and CCONJ dti-1425 48 33 in in ADP dti-1425 48 34 vitro vitro X dti-1425 48 35 studies study NOUN dti-1425 48 36 have have AUX dti-1425 48 37 showed show VERB dti-1425 48 38 that that SCONJ dti-1425 48 39 exposing expose VERB dti-1425 48 40 a a DET dti-1425 48 41 gics gic NOUN dti-1425 48 42 to to PART dti-1425 48 43 saline saline VERB dti-1425 48 44 causes cause VERB dti-1425 48 45 the the DET dti-1425 48 46 loss loss NOUN dti-1425 48 47 of of ADP dti-1425 48 48 6.7 6.7 NUM dti-1425 48 49 % % NOUN dti-1425 48 50 , , PUNCT dti-1425 48 51 40.5 40.5 NUM dti-1425 48 52 % % NOUN dti-1425 48 53 , , PUNCT dti-1425 48 54 and and CCONJ dti-1425 48 55 100 100 NUM dti-1425 48 56 % % NOUN dti-1425 48 57 of of ADP dti-1425 48 58 the the DET dti-1425 48 59 gentamicin gentamicin NOUN dti-1425 48 60 after after ADP dti-1425 48 61 2 2 NUM dti-1425 48 62 seconds second NOUN dti-1425 48 63 , , PUNCT dti-1425 48 64 1 1 NUM dti-1425 48 65 minute minute NOUN dti-1425 48 66 , , PUNCT dti-1425 48 67 and and CCONJ dti-1425 48 68 6 6 NUM dti-1425 48 69 hours hour NOUN dti-1425 48 70 , , PUNCT dti-1425 48 71 respectively.32 respectively.32 SCONJ dti-1425 48 72 manufacturers manufacturer NOUN dti-1425 48 73 recommend recommend VERB dti-1425 48 74 not not PART dti-1425 48 75 to to PART dti-1425 48 76 soak soak VERB dti-1425 48 77 the the DET dti-1425 48 78 gics gic NOUN dti-1425 48 79 prior prior ADV dti-1425 48 80 to to ADP dti-1425 48 81 use use NOUN dti-1425 48 82 . . PUNCT dti-1425 49 1 gics gic NOUN dti-1425 49 2 use use VERB dti-1425 49 3 in in ADP dti-1425 49 4 high high ADJ dti-1425 49 5 - - PUNCT dti-1425 49 6 risk risk NOUN dti-1425 49 7 cardiac cardiac ADJ dti-1425 49 8 surgery surgery NOUN dti-1425 49 9 patients patient NOUN dti-1425 49 10 obesity obesity NOUN dti-1425 49 11 represents represent VERB dti-1425 49 12 one one NUM dti-1425 49 13 of of ADP dti-1425 49 14 the the DET dti-1425 49 15 most most ADV dti-1425 49 16 important important ADJ dti-1425 49 17 risk risk NOUN dti-1425 49 18 factors factor NOUN dti-1425 49 19 for for ADP dti-1425 49 20 the the DET dti-1425 49 21 development development NOUN dti-1425 49 22 of of ADP dti-1425 49 23 swi swi PROPN dti-1425 49 24 in in ADP dti-1425 49 25 cardiac cardiac ADJ dti-1425 49 26 surgery,15 surgery,15 NOUN dti-1425 50 1 but but CCONJ dti-1425 50 2 there there PRON dti-1425 50 3 are be VERB dti-1425 50 4 contrasting contrast VERB dti-1425 50 5 data datum NOUN dti-1425 50 6 on on ADP dti-1425 50 7 the the DET dti-1425 50 8 effect effect NOUN dti-1425 50 9 of of ADP dti-1425 50 10 the the DET dti-1425 50 11 gics gic NOUN dti-1425 50 12 on on ADP dti-1425 50 13 preventing prevent VERB dti-1425 50 14 this this DET dti-1425 50 15 complication complication NOUN dti-1425 50 16 in in ADP dti-1425 50 17 this this DET dti-1425 50 18 subgroup subgroup NOUN dti-1425 50 19 of of ADP dti-1425 50 20 patients patient NOUN dti-1425 50 21 . . PUNCT dti-1425 51 1 an an DET dti-1425 51 2 important important ADJ dti-1425 51 3 multicenter multicenter NOUN dti-1425 51 4 randomized randomize VERB dti-1425 51 5 controlled control VERB dti-1425 51 6 trial trial NOUN dti-1425 51 7 has have AUX dti-1425 51 8 involved involve VERB dti-1425 51 9 1502 1502 NUM dti-1425 51 10 high high ADJ dti-1425 51 11 - - PUNCT dti-1425 51 12 risk risk NOUN dti-1425 51 13 patients patient NOUN dti-1425 51 14 in in ADP dti-1425 51 15 48 48 NUM dti-1425 51 16 centers center NOUN dti-1425 51 17 ( ( PUNCT dti-1425 51 18 table table NOUN dti-1425 51 19 2).31 2).31 NUM dti-1425 51 20 in in ADP dti-1425 51 21 this this DET dti-1425 51 22 study study NOUN dti-1425 51 23 , , PUNCT dti-1425 51 24 1006 1006 NUM dti-1425 51 25 patients patient NOUN dti-1425 51 26 ( ( PUNCT dti-1425 51 27 67 67 NUM dti-1425 51 28 % % NOUN dti-1425 51 29 of of ADP dti-1425 51 30 the the DET dti-1425 51 31 population population NOUN dti-1425 51 32 ) ) PUNCT dti-1425 51 33 were be AUX dti-1425 51 34 diabetic diabetic ADJ dti-1425 51 35 and and CCONJ dti-1425 51 36 1137 1137 NUM dti-1425 51 37 patients patient NOUN dti-1425 51 38 ( ( PUNCT dti-1425 51 39 76 76 NUM dti-1425 51 40 % % NOUN dti-1425 51 41 ) ) PUNCT dti-1425 51 42 were be AUX dti-1425 51 43 obese obese ADJ dti-1425 51 44 with with ADP dti-1425 51 45 a a DET dti-1425 51 46 median median ADJ dti-1425 51 47 body body NOUN dti-1425 51 48 mass mass NOUN dti-1425 51 49 index index NOUN dti-1425 51 50 ( ( PUNCT dti-1425 51 51 bmi bmi PROPN dti-1425 51 52 ) ) PUNCT dti-1425 51 53 of of ADP dti-1425 51 54 32.9 32.9 NUM dti-1425 51 55     SPACE dti-1425 51 56 kg kg PROPN dti-1425 51 57 / / SYM dti-1425 51 58 m2 m2 PROPN dti-1425 51 59 . . PROPN dti-1425 52 1 with with ADP dti-1425 52 2 a a DET dti-1425 52 3 90 90 NUM dti-1425 52 4 - - PUNCT dti-1425 52 5 day day NOUN dti-1425 52 6 postoperative postoperative ADJ dti-1425 52 7 follow follow NOUN dti-1425 52 8 - - PUNCT dti-1425 52 9 up up NOUN dti-1425 52 10 , , PUNCT dti-1425 52 11 the the DET dti-1425 52 12 authors author NOUN dti-1425 52 13 reported report VERB dti-1425 52 14 a a DET dti-1425 52 15 comparable comparable ADJ dti-1425 52 16 incidence incidence NOUN dti-1425 52 17 of of ADP dti-1425 52 18 swis swis NOUN dti-1425 52 19 in in ADP dti-1425 52 20 the the DET dti-1425 52 21 intention intention NOUN dti-1425 52 22 - - PUNCT dti-1425 52 23 to to ADP dti-1425 52 24 - - PUNCT dti-1425 52 25 treat treat VERB dti-1425 52 26 analysis analysis NOUN dti-1425 52 27 , , PUNCT dti-1425 52 28 with with ADP dti-1425 52 29 an an DET dti-1425 52 30 incidence incidence NOUN dti-1425 52 31 of of ADP dti-1425 52 32 dswi dswi NOUN dti-1425 52 33 of of ADP dti-1425 52 34 8.4 8.4 NUM dti-1425 52 35 % % NOUN dti-1425 52 36 in in ADP dti-1425 52 37 the the DET dti-1425 52 38 gics gic NOUN dti-1425 52 39 group group NOUN dti-1425 52 40 vs vs ADP dti-1425 52 41 8.7 8.7 NUM dti-1425 52 42 % % NOUN dti-1425 52 43 in in ADP dti-1425 52 44 the the DET dti-1425 52 45 control control NOUN dti-1425 52 46 group group NOUN dti-1425 52 47 ( ( PUNCT dti-1425 52 48 p p X dti-1425 52 49     SPACE dti-1425 52 50 = = NOUN dti-1425 52 51     SPACE dti-1425 52 52 0.83 0.83 NUM dti-1425 52 53 ) ) PUNCT dti-1425 52 54 . . PUNCT dti-1425 53 1 similar similar ADJ dti-1425 53 2 results result NOUN dti-1425 53 3 have have AUX dti-1425 53 4 been be AUX dti-1425 53 5 reported report VERB dti-1425 53 6 in in ADP dti-1425 53 7 the the DET dti-1425 53 8 per per ADP dti-1425 53 9 - - PUNCT dti-1425 53 10 protocol protocol NOUN dti-1425 53 11 analysis analysis NOUN dti-1425 53 12 ( ( PUNCT dti-1425 53 13 8.4 8.4 NUM dti-1425 53 14 % % NOUN dti-1425 53 15 vs vs ADP dti-1425 53 16 8.6 8.6 NUM dti-1425 53 17 % % NOUN dti-1425 53 18 , , PUNCT dti-1425 53 19 p p X dti-1425 53 20     SPACE dti-1425 53 21 = = NOUN dti-1425 53 22     SPACE dti-1425 53 23 0.89 0.89 NUM dti-1425 53 24 ) ) PUNCT dti-1425 53 25 . . PUNCT dti-1425 54 1 a a DET dti-1425 54 2 further further ADJ dti-1425 54 3 subanalysis subanalysis NOUN dti-1425 54 4 of of ADP dti-1425 54 5 this this DET dti-1425 54 6 study study NOUN dti-1425 54 7 , , PUNCT dti-1425 54 8 targeting target VERB dti-1425 54 9 the the DET dti-1425 54 10 very very ADV dti-1425 54 11 high high ADJ dti-1425 54 12 - - PUNCT dti-1425 54 13 risk risk NOUN dti-1425 54 14 group group NOUN dti-1425 54 15 and and CCONJ dti-1425 54 16 including include VERB dti-1425 54 17 patients patient NOUN dti-1425 54 18 who who PRON dti-1425 54 19 table table VERB dti-1425 54 20 2 2 NUM dti-1425 54 21 . . PUNCT dti-1425 54 22 comparison comparison NOUN dti-1425 54 23 of of ADP dti-1425 54 24 various various ADJ dti-1425 54 25 studies study NOUN dti-1425 54 26 that that PRON dti-1425 54 27 have have AUX dti-1425 54 28 investigated investigate VERB dti-1425 54 29 gics gic NOUN dti-1425 54 30 use use VERB dti-1425 54 31 in in ADP dti-1425 54 32 high high ADJ dti-1425 54 33 - - PUNCT dti-1425 54 34 risk risk NOUN dti-1425 54 35 cardiac cardiac ADJ dti-1425 54 36 surgery surgery NOUN dti-1425 54 37 patients patient NOUN dti-1425 54 38 . . PUNCT dti-1425 55 1 author author NOUN dti-1425 55 2 type type NOUN dti-1425 55 3 of of ADP dti-1425 55 4 study study NOUN dti-1425 55 5 subgroup subgroup PROPN dti-1425 55 6 outcome outcome PROPN dti-1425 55 7 gics gic NOUN dti-1425 55 8 no no DET dti-1425 55 9 gics gic NOUN dti-1425 55 10 p p ADJ dti-1425 55 11 - - PUNCT dti-1425 55 12 value value NOUN dti-1425 55 13 bennett bennett PROPN dti-1425 55 14 - - PUNCT dti-1425 55 15 guerrero guerrero PROPN dti-1425 55 16 et et NOUN dti-1425 56 1 al31 al31 PROPN dti-1425 56 2 multicenter multicenter NOUN dti-1425 56 3 rct rct PROPN dti-1425 56 4 , , PUNCT dti-1425 56 5 1502 1502 NUM dti-1425 56 6 pts pts ADP dti-1425 56 7 all all DET dti-1425 56 8 pts pt NOUN dti-1425 56 9 any any DET dti-1425 56 10 swi swi NOUN dti-1425 56 11 ( ( PUNCT dti-1425 56 12 itt itt PROPN dti-1425 56 13 ) ) PUNCT dti-1425 56 14 8.4 8.4 NUM dti-1425 56 15 % % NOUN dti-1425 56 16 8.7 8.7 NUM dti-1425 56 17 % % NOUN dti-1425 56 18 0.83 0.83 NUM dti-1425 56 19 any any DET dti-1425 56 20 swi swi NOUN dti-1425 56 21 ( ( PUNCT dti-1425 56 22 pp pp PROPN dti-1425 56 23 ) ) PUNCT dti-1425 56 24 8.4 8.4 NUM dti-1425 56 25 % % NOUN dti-1425 56 26 8.6 8.6 NUM dti-1425 56 27 % % NOUN dti-1425 56 28 0.89 0.89 NUM dti-1425 56 29 bmi bmi NOUN dti-1425 56 30   CCONJ dti-1425 56 31 30 30 NUM dti-1425 56 32 any any DET dti-1425 56 33 swi swi NUM dti-1425 56 34 8.1 8.1 NUM dti-1425 56 35 % % NOUN dti-1425 56 36 4.2 4.2 NUM dti-1425 56 37 % % NOUN dti-1425 56 38 0.07 0.07 NUM dti-1425 56 39 diabetes diabetes NOUN dti-1425 56 40 any any DET dti-1425 56 41 swi swi NOUN dti-1425 56 42 4 4 NUM dti-1425 56 43 % % NOUN dti-1425 56 44 5.4 5.4 NUM dti-1425 56 45 % % NOUN dti-1425 56 46 0.52 0.52 NUM dti-1425 56 47 bmi bmi NOUN dti-1425 56 48   CCONJ dti-1425 56 49 30 30 NUM dti-1425 56 50 + + NUM dti-1425 56 51 diabetes diabete VERB dti-1425 56 52 any any DET dti-1425 56 53 swi swi NUM dti-1425 56 54 11.1 11.1 NUM dti-1425 56 55 % % NOUN dti-1425 56 56 13.8 13.8 NUM dti-1425 56 57 % % NOUN dti-1425 56 58 0.30 0.30 NUM dti-1425 56 59 friberg friberg PROPN dti-1425 56 60 et et PROPN dti-1425 57 1 al16 al16 PROPN dti-1425 57 2 two two NUM dti-1425 57 3 - - PUNCT dti-1425 57 4 centers center NOUN dti-1425 57 5 rct rct PROPN dti-1425 57 6 , , PUNCT dti-1425 57 7 2000 2000 NUM dti-1425 57 8 pts pts ADP dti-1425 57 9 all all DET dti-1425 57 10 pts pt NOUN dti-1425 57 11 any any DET dti-1425 57 12 swi swi NUM dti-1425 57 13 4.3 4.3 NUM dti-1425 57 14 % % NOUN dti-1425 57 15 9 9 NUM dti-1425 57 16 % % NOUN dti-1425 57 17 0.001 0.001 X dti-1425 57 18 sswi sswi ADJ dti-1425 57 19 1.9 1.9 NUM dti-1425 57 20 % % NOUN dti-1425 57 21 5.7 5.7 NUM dti-1425 57 22 % % NOUN dti-1425 57 23 0.001 0.001 NOUN dti-1425 57 24 dswi dswi ADJ dti-1425 57 25 2.3 2.3 NUM dti-1425 57 26 % % NOUN dti-1425 57 27 3.3 3.3 NUM dti-1425 57 28 % % NOUN dti-1425 57 29 0.20 0.20 NUM dti-1425 57 30 no no DET dti-1425 57 31 reoperation reoperation NOUN dti-1425 57 32 or or CCONJ dti-1425 57 33 early early ADJ dti-1425 57 34 death death NOUN dti-1425 57 35 sswi sswi ADJ dti-1425 57 36 2.7 2.7 NUM dti-1425 57 37 % % NOUN dti-1425 57 38 6.7 6.7 NUM dti-1425 57 39 % % NOUN dti-1425 57 40 0.001 0.001 NOUN dti-1425 57 41 dswi dswi ADJ dti-1425 57 42 2.1 2.1 NUM dti-1425 57 43 % % NOUN dti-1425 57 44 3.3 3.3 NUM dti-1425 57 45 % % NOUN dti-1425 57 46 0.088 0.088 NUM dti-1425 57 47 diabetes diabetes NOUN dti-1425 57 48 sswi sswi ADJ dti-1425 57 49 1.67 1.67 NUM dti-1425 57 50 % % NOUN dti-1425 57 51 7.47 7.47 NUM dti-1425 57 52 % % NOUN dti-1425 57 53 0.0086 0.0086 NUM dti-1425 57 54 dswi dswi ADJ dti-1425 57 55 3.89 3.89 NUM dti-1425 57 56 % % NOUN dti-1425 57 57 9.77 9.77 NUM dti-1425 57 58 % % NOUN dti-1425 57 59 0.028 0.028 NUM dti-1425 57 60 bmi bmi X dti-1425 57 61   CCONJ dti-1425 57 62 25 25 NUM dti-1425 57 63 sswi sswi ADJ dti-1425 57 64 2.16 2.16 NUM dti-1425 57 65 % % NOUN dti-1425 57 66 6.45 6.45 NUM dti-1425 57 67 % % NOUN dti-1425 57 68 0.001 0.001 NOUN dti-1425 57 69 dswi dswi ADJ dti-1425 57 70 2.47 2.47 NUM dti-1425 57 71 % % NOUN dti-1425 57 72 4.45 4.45 NUM dti-1425 57 73 % % NOUN dti-1425 57 74 0.050 0.050 NUM dti-1425 57 75 birgand birgand NOUN dti-1425 57 76 et et NOUN dti-1425 58 1 al35 al35 PROPN dti-1425 58 2 single single ADJ dti-1425 58 3 center center NOUN dti-1425 58 4 cs cs PROPN dti-1425 58 5 , , PUNCT dti-1425 58 6 552 552 NUM dti-1425 58 7 pts pt NOUN dti-1425 58 8 bima bima PROPN dti-1425 58 9 + + CCONJ dti-1425 58 10 bmi bmi X dti-1425 58 11   NUM dti-1425 58 12 30 30 NUM dti-1425 58 13 or or CCONJ dti-1425 58 14 i i PRON dti-1425 58 15 d d PROPN dti-1425 58 16 diabetes diabetes NOUN dti-1425 58 17 dswi dswi VERB dti-1425 58 18 12.6 12.6 NUM dti-1425 58 19 % % NOUN dti-1425 58 20 13.8 13.8 NUM dti-1425 58 21 % % NOUN dti-1425 58 22 ns ns NUM dti-1425 58 23 abbreviations abbreviation NOUN dti-1425 58 24 : : PUNCT dti-1425 58 25 bima bima PROPN dti-1425 58 26 , , PUNCT dti-1425 58 27 bilateral bilateral ADJ dti-1425 58 28 internal internal ADJ dti-1425 58 29 mammary mammary NOUN dti-1425 58 30 ; ; PUNCT dti-1425 58 31 cs cs ADJ dti-1425 58 32 , , PUNCT dti-1425 58 33 cohort cohort NOUN dti-1425 58 34 study study NOUN dti-1425 58 35 ; ; PUNCT dti-1425 58 36 dswi dswi ADJ dti-1425 58 37 , , PUNCT dti-1425 58 38 deep deep ADJ dti-1425 58 39 sternal sternal ADJ dti-1425 58 40 wound wound NOUN dti-1425 58 41 infection infection NOUN dti-1425 58 42 ; ; PUNCT dti-1425 58 43 bmi bmi PROPN dti-1425 58 44 , , PUNCT dti-1425 58 45 body body NOUN dti-1425 58 46 mass mass PROPN dti-1425 58 47 index index NOUN dti-1425 58 48 ; ; PUNCT dti-1425 58 49 gics gic NOUN dti-1425 58 50 , , PUNCT dti-1425 58 51 gentamicin gentamicin NOUN dti-1425 58 52 - - PUNCT dti-1425 58 53 impregnated impregnate VERB dti-1425 58 54 collagen collagen NOUN dti-1425 58 55 sponge sponge NOUN dti-1425 58 56 ; ; PUNCT dti-1425 58 57 i i PROPN dti-1425 58 58 d d PROPN dti-1425 58 59 , , PUNCT dti-1425 58 60 insulin insulin NOUN dti-1425 58 61 - - PUNCT dti-1425 58 62 dependent dependent ADJ dti-1425 58 63 ; ; PUNCT dti-1425 59 1 itt itt VERB dti-1425 59 2 , , PUNCT dti-1425 59 3 intention intention NOUN dti-1425 59 4 - - PUNCT dti-1425 59 5 to to ADP dti-1425 59 6 - - PUNCT dti-1425 59 7 treat treat NOUN dti-1425 59 8 ; ; PUNCT dti-1425 59 9 ns ns X dti-1425 59 10 , , PUNCT dti-1425 59 11 not not PART dti-1425 59 12 significant significant ADJ dti-1425 59 13 ; ; PUNCT dti-1425 59 14 pp pp CCONJ dti-1425 59 15 , , PUNCT dti-1425 59 16 per per ADP dti-1425 59 17 - - PUNCT dti-1425 59 18 protocol protocol NOUN dti-1425 59 19 ; ; PUNCT dti-1425 59 20 pts pt NOUN dti-1425 59 21 , , PUNCT dti-1425 59 22 patients patient NOUN dti-1425 59 23 ; ; PUNCT dti-1425 59 24 rct rct PROPN dti-1425 59 25 , , PUNCT dti-1425 59 26 randomized randomize VERB dti-1425 59 27 controlled control VERB dti-1425 59 28 trial trial NOUN dti-1425 59 29 ; ; PUNCT dti-1425 59 30 sswi sswi ADJ dti-1425 59 31 , , PUNCT dti-1425 59 32 superficial superficial ADJ dti-1425 59 33 sternal sternal ADJ dti-1425 59 34 wound wound NOUN dti-1425 59 35 infection infection NOUN dti-1425 59 36 ; ; PUNCT dti-1425 59 37 swi swi NUM dti-1425 59 38 , , PUNCT dti-1425 59 39 sternal sternal ADJ dti-1425 59 40 wound wound NOUN dti-1425 59 41 infection infection NOUN dti-1425 59 42 . . PUNCT dti-1425 60 1 http://www.la-press.com http://www.la-press.com X dti-1425 61 1 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1425 61 2 rapetto rapetto PROPN dti-1425 61 3 et et NOUN dti-1425 61 4 al al PROPN dti-1425 61 5 12 12 NUM dti-1425 61 6 drug drug NOUN dti-1425 61 7 target target NOUN dti-1425 61 8 insights insight NOUN dti-1425 61 9 2016:10(s1 2016:10(s1 NUM dti-1425 61 10 ) ) PUNCT dti-1425 61 11 were be AUX dti-1425 61 12 both both CCONJ dti-1425 61 13 obese obese ADJ dti-1425 61 14 and and CCONJ dti-1425 61 15 diabetic diabetic ADJ dti-1425 61 16 , , PUNCT dti-1425 61 17 showed show VERB dti-1425 61 18 no no DET dti-1425 61 19 differences difference NOUN dti-1425 61 20 between between ADP dti-1425 61 21 the the DET dti-1425 61 22 two two NUM dti-1425 61 23 groups group NOUN dti-1425 61 24 ( ( PUNCT dti-1425 61 25 11.1 11.1 NUM dti-1425 61 26 % % NOUN dti-1425 61 27 vs vs ADP dti-1425 61 28 13.8 13.8 NUM dti-1425 61 29 % % NOUN dti-1425 61 30 , , PUNCT dti-1425 62 1 p p X dti-1425 62 2     SPACE dti-1425 62 3 = = NOUN dti-1425 62 4     SPACE dti-1425 62 5 0.30 0.30 NUM dti-1425 62 6 ) ) PUNCT dti-1425 62 7 . . PUNCT dti-1425 63 1 the the DET dti-1425 63 2 authors author NOUN dti-1425 63 3 concluded conclude VERB dti-1425 63 4 that that SCONJ dti-1425 63 5 the the DET dti-1425 63 6 use use NOUN dti-1425 63 7 of of ADP dti-1425 63 8 a a DET dti-1425 63 9 gics gic NOUN dti-1425 63 10 did do AUX dti-1425 63 11 not not PART dti-1425 63 12 reduce reduce VERB dti-1425 63 13 the the DET dti-1425 63 14 90 90 NUM dti-1425 63 15 - - PUNCT dti-1425 63 16 day day NOUN dti-1425 63 17 swi swi NOUN dti-1425 63 18 rate.31 rate.31 NOUN dti-1425 63 19 one one NUM dti-1425 63 20 of of ADP dti-1425 63 21 the the DET dti-1425 63 22 most most ADV dti-1425 63 23 controversial controversial ADJ dti-1425 63 24 points point NOUN dti-1425 63 25 regarding regard VERB dti-1425 63 26 this this DET dti-1425 63 27 study study NOUN dti-1425 63 28 was be AUX dti-1425 63 29 the the DET dti-1425 63 30 fact fact NOUN dti-1425 63 31 that that SCONJ dti-1425 63 32 the the DET dti-1425 63 33 gics gic NOUN dti-1425 63 34 was be AUX dti-1425 63 35 wetted wet VERB dti-1425 63 36 in in ADP dti-1425 63 37 saline saline NOUN dti-1425 63 38 before before ADP dti-1425 63 39 application application NOUN dti-1425 63 40 : : PUNCT dti-1425 63 41 the the DET dti-1425 63 42 consequence consequence NOUN dti-1425 63 43 of of ADP dti-1425 63 44 this this PRON dti-1425 63 45 may may AUX dti-1425 63 46 have have AUX dti-1425 63 47 influenced influence VERB dti-1425 63 48 the the DET dti-1425 63 49 gentamicin gentamicin PROPN dti-1425 63 50 release,32,33 release,32,33 PROPN dti-1425 63 51 and and CCONJ dti-1425 63 52 therefore therefore ADV dti-1425 63 53 the the DET dti-1425 63 54 outcome outcome NOUN dti-1425 63 55 of of ADP dti-1425 63 56 the the DET dti-1425 63 57 study study NOUN dti-1425 63 58 would would AUX dti-1425 63 59 have have AUX dti-1425 63 60 been be AUX dti-1425 63 61 affected affect VERB dti-1425 63 62 . . PUNCT dti-1425 64 1 different different ADJ dti-1425 64 2 results result NOUN dti-1425 64 3 were be AUX dti-1425 64 4 reported report VERB dti-1425 64 5 by by ADP dti-1425 64 6 a a DET dti-1425 64 7 previously previously ADV dti-1425 64 8 published publish VERB dti-1425 64 9 randomized randomize VERB dti-1425 64 10 controlled control VERB dti-1425 64 11 trial,16 trial,16 NOUN dti-1425 64 12 where where SCONJ dti-1425 64 13 the the DET dti-1425 64 14 impact impact NOUN dti-1425 64 15 of of ADP dti-1425 64 16 obesity obesity NOUN dti-1425 64 17 was be AUX dti-1425 64 18 specifically specifically ADV dti-1425 64 19 subanalyzed subanalyze VERB dti-1425 64 20 . . PUNCT dti-1425 65 1 with with ADP dti-1425 65 2 a a DET dti-1425 65 3 cutoff cutoff NOUN dti-1425 65 4 of of ADP dti-1425 65 5 bmi bmi NOUN dti-1425 65 6     SPACE dti-1425 65 7   ADV dti-1425 65 8     SPACE dti-1425 65 9 25 25 NUM dti-1425 65 10     SPACE dti-1425 65 11 kg kg PROPN dti-1425 65 12 / / SYM dti-1425 65 13 m2 m2 PROPN dti-1425 65 14 ( ( PUNCT dti-1425 65 15 1299 1299 NUM dti-1425 65 16 patients patient NOUN dti-1425 65 17 ) ) PUNCT dti-1425 65 18 , , PUNCT dti-1425 65 19 the the DET dti-1425 65 20 authors author NOUN dti-1425 65 21 reported report VERB dti-1425 65 22 a a DET dti-1425 65 23 significantly significantly ADV dti-1425 65 24 reduced reduce VERB dti-1425 65 25 incidence incidence NOUN dti-1425 65 26 of of ADP dti-1425 65 27 sswis sswis NOUN dti-1425 65 28 ( ( PUNCT dti-1425 65 29 2.16 2.16 NUM dti-1425 65 30 % % NOUN dti-1425 65 31 vs vs ADP dti-1425 65 32 6.45 6.45 NUM dti-1425 65 33 % % NOUN dti-1425 65 34 , , PUNCT dti-1425 65 35 p p X dti-1425 65 36     SPACE dti-1425 65 37   NOUN dti-1425 65 38     SPACE dti-1425 65 39 0.001 0.001 NUM dti-1425 65 40 ) ) PUNCT dti-1425 65 41 and and CCONJ dti-1425 65 42 dswis dswis NOUN dti-1425 65 43 ( ( PUNCT dti-1425 65 44 2.47 2.47 NUM dti-1425 65 45 % % NOUN dti-1425 65 46 vs vs ADP dti-1425 65 47 4.45 4.45 NUM dti-1425 65 48 % % NOUN dti-1425 65 49 , , PUNCT dti-1425 65 50 p p X dti-1425 65 51     SPACE dti-1425 65 52 = = NOUN dti-1425 65 53     SPACE dti-1425 65 54 0.05 0.05 NUM dti-1425 65 55 ) ) PUNCT dti-1425 65 56 in in ADP dti-1425 65 57 the the DET dti-1425 65 58 gics gic NOUN dti-1425 65 59 group group NOUN dti-1425 65 60 . . PUNCT dti-1425 66 1 the the DET dti-1425 66 2 analysis analysis NOUN dti-1425 66 3 of of ADP dti-1425 66 4 the the DET dti-1425 66 5 whole whole ADJ dti-1425 66 6 population population NOUN dti-1425 66 7 confirmed confirm VERB dti-1425 66 8 these these DET dti-1425 66 9 results result NOUN dti-1425 66 10 only only ADV dti-1425 66 11 for for ADP dti-1425 66 12 sswis sswis NOUN dti-1425 66 13 , , PUNCT dti-1425 66 14 whereas whereas SCONJ dti-1425 66 15 there there PRON dti-1425 66 16 were be VERB dti-1425 66 17 no no DET dti-1425 66 18 differences difference NOUN dti-1425 66 19 in in ADP dti-1425 66 20 terms term NOUN dti-1425 66 21 of of ADP dti-1425 66 22 dswis dswis NOUN dti-1425 66 23 ( ( PUNCT dti-1425 66 24 p p X dti-1425 66 25     SPACE dti-1425 66 26 = = NOUN dti-1425 66 27     SPACE dti-1425 66 28 0.2 0.2 NUM dti-1425 66 29 ) ) PUNCT dti-1425 66 30 ; ; PUNCT dti-1425 66 31 these these DET dti-1425 66 32 outcomes outcome NOUN dti-1425 66 33 can can AUX dti-1425 66 34 be be AUX dti-1425 66 35 interpreted interpret VERB dti-1425 66 36 as as ADP dti-1425 66 37 a a DET dti-1425 66 38 stronger strong ADJ dti-1425 66 39 effect effect NOUN dti-1425 66 40 of of ADP dti-1425 66 41 gics gic NOUN dti-1425 66 42 in in ADP dti-1425 66 43 preventing prevent VERB dti-1425 66 44 dswi dswi NOUN dti-1425 66 45 in in ADP dti-1425 66 46 the the DET dti-1425 66 47 obese obese ADJ dti-1425 66 48 group group NOUN dti-1425 66 49 of of ADP dti-1425 66 50 patients patient NOUN dti-1425 66 51 . . PUNCT dti-1425 67 1 another another DET dti-1425 67 2 subgroup subgroup NOUN dti-1425 67 3 at at ADP dti-1425 67 4 high high ADJ dti-1425 67 5 risk risk NOUN dti-1425 67 6 of of ADP dti-1425 67 7 swi swi NOUN dti-1425 67 8 includes include VERB dti-1425 67 9 patients patient NOUN dti-1425 67 10 who who PRON dti-1425 67 11 undergo undergo VERB dti-1425 67 12 bima bima PROPN dti-1425 67 13 harvesting harvesting NOUN dti-1425 67 14 during during ADP dti-1425 67 15 coronary coronary ADJ dti-1425 67 16 artery artery NOUN dti-1425 67 17 bypass bypass NOUN dti-1425 67 18 grafting grafting NOUN dti-1425 67 19 ( ( PUNCT dti-1425 67 20 cabg cabg NOUN dti-1425 67 21 ) ) PUNCT dti-1425 67 22 , , PUNCT dti-1425 67 23 as as SCONJ dti-1425 67 24 this this DET dti-1425 67 25 technique technique NOUN dti-1425 67 26 can can AUX dti-1425 67 27 impair impair VERB dti-1425 67 28 sternal sternal ADJ dti-1425 67 29 vascularization.34 vascularization.34 NOUN dti-1425 67 30 a a DET dti-1425 67 31 single single ADJ dti-1425 67 32 - - PUNCT dti-1425 67 33 center center NOUN dti-1425 67 34 study study NOUN dti-1425 67 35 , , PUNCT dti-1425 67 36 published publish VERB dti-1425 67 37 in in ADP dti-1425 67 38 2012 2012 NUM dti-1425 67 39 by by ADP dti-1425 67 40 birgand birgand NOUN dti-1425 68 1 et et PROPN dti-1425 68 2 al al PROPN dti-1425 68 3 ( ( PUNCT dti-1425 68 4 table table NOUN dti-1425 68 5 2 2 NUM dti-1425 68 6 ) ) PUNCT dti-1425 68 7 , , PUNCT dti-1425 68 8 compared compare VERB dti-1425 68 9 the the DET dti-1425 68 10 incidence incidence NOUN dti-1425 68 11 of of ADP dti-1425 68 12 dswi dswi ADJ dti-1425 68 13 requiring require VERB dti-1425 68 14 surgery surgery NOUN dti-1425 68 15 in in ADP dti-1425 68 16 high high ADJ dti-1425 68 17 - - PUNCT dti-1425 68 18 risk risk NOUN dti-1425 68 19 patients patient NOUN dti-1425 68 20 defined define VERB dti-1425 68 21 as as ADP dti-1425 68 22 bima bima PROPN dti-1425 68 23 harvesting harvesting NOUN dti-1425 68 24 plus plus CCONJ dti-1425 68 25 overweight overweight NOUN dti-1425 68 26 ( ( PUNCT dti-1425 68 27 bmi bmi NOUN dti-1425 68 28     SPACE dti-1425 68 29   NOUN dti-1425 68 30     SPACE dti-1425 68 31 30 30 NUM dti-1425 68 32     SPACE dti-1425 68 33 kg kg PROPN dti-1425 68 34 / / SYM dti-1425 68 35 m2 m2 PROPN dti-1425 68 36 ) ) PUNCT dti-1425 68 37 and/or and/or CCONJ dti-1425 68 38 insulin insulin NOUN dti-1425 68 39 - - PUNCT dti-1425 68 40 dependent dependent ADJ dti-1425 68 41 diabetes.35 diabetes.35 NOUN dti-1425 68 42 the the DET dti-1425 68 43 authors author NOUN dti-1425 68 44 did do AUX dti-1425 68 45 not not PART dti-1425 68 46 find find VERB dti-1425 68 47 any any DET dti-1425 68 48 difference difference NOUN dti-1425 68 49 regarding regard VERB dti-1425 68 50 the the DET dti-1425 68 51 incidence incidence NOUN dti-1425 68 52 of of ADP dti-1425 68 53 dswi dswi NOUN dti-1425 68 54 between between ADP dti-1425 68 55 patients patient NOUN dti-1425 68 56 receiving receive VERB dti-1425 68 57 a a DET dti-1425 68 58 gics gic NOUN dti-1425 68 59 and and CCONJ dti-1425 68 60 those those PRON dti-1425 68 61 who who PRON dti-1425 68 62 did do AUX dti-1425 68 63 not not PART dti-1425 68 64 receive receive VERB dti-1425 68 65 it it PRON dti-1425 68 66 ( ( PUNCT dti-1425 68 67 12.6 12.6 NUM dti-1425 68 68 % % NOUN dti-1425 68 69 vs vs ADP dti-1425 68 70 13.8 13.8 NUM dti-1425 68 71 % % NOUN dti-1425 68 72 , , PUNCT dti-1425 68 73 respectively respectively ADV dti-1425 68 74 ) ) PUNCT dti-1425 68 75 ; ; PUNCT dti-1425 68 76 interestingly interestingly ADV dti-1425 68 77 , , PUNCT dti-1425 68 78 in in ADP dti-1425 68 79 that that DET dti-1425 68 80 series series NOUN dti-1425 68 81 , , PUNCT dti-1425 68 82 the the DET dti-1425 68 83 probability probability NOUN dti-1425 68 84 of of ADP dti-1425 68 85 dswi dswi NOUN dti-1425 68 86 caused cause VERB dti-1425 68 87 by by ADP dti-1425 68 88 a a DET dti-1425 68 89 gentamicin gentamicin NOUN dti-1425 68 90 - - PUNCT dti-1425 68 91 resistant resistant ADJ dti-1425 68 92 bacterium bacterium NOUN dti-1425 68 93 was be AUX dti-1425 68 94 higher high ADJ dti-1425 68 95 in in ADP dti-1425 68 96 the the DET dti-1425 68 97 gics gic NOUN dti-1425 68 98 group group NOUN dti-1425 68 99 ( ( PUNCT dti-1425 68 100 21/27 21/27 NUM dti-1425 68 101 , , PUNCT dti-1425 68 102 77.8 77.8 NUM dti-1425 68 103 % % NOUN dti-1425 68 104 ) ) PUNCT dti-1425 68 105 compared compare VERB dti-1425 68 106 with with ADP dti-1425 68 107 the the DET dti-1425 68 108 other other ADJ dti-1425 68 109 patients patient NOUN dti-1425 68 110 ( ( PUNCT dti-1425 68 111 23/56 23/56 NUM dti-1425 68 112 , , PUNCT dti-1425 68 113 41.1 41.1 NUM dti-1425 68 114 % % NOUN dti-1425 68 115 ; ; PUNCT dti-1425 68 116 p p X dti-1425 68 117     SPACE dti-1425 68 118   NOUN dti-1425 68 119     SPACE dti-1425 68 120 0.01 0.01 NUM dti-1425 68 121 ) ) PUNCT dti-1425 68 122 . . PUNCT dti-1425 69 1 again again ADV dti-1425 69 2 , , PUNCT dti-1425 69 3 as as ADP dti-1425 69 4 in in ADP dti-1425 69 5 the the DET dti-1425 69 6 above above ADV dti-1425 69 7 - - PUNCT dti-1425 69 8 mentioned mention VERB dti-1425 69 9 study study NOUN dti-1425 69 10 , , PUNCT dti-1425 69 11 gics gic NOUN dti-1425 69 12 presoaking presoake VERB dti-1425 69 13 in in ADP dti-1425 69 14 saline saline ADJ dti-1425 69 15 solution solution NOUN dti-1425 69 16 represented represent VERB dti-1425 69 17 a a DET dti-1425 69 18 weakness weakness NOUN dti-1425 69 19 . . PUNCT dti-1425 70 1 once once SCONJ dti-1425 70 2 we we PRON dti-1425 70 3 consider consider VERB dti-1425 70 4 the the DET dti-1425 70 5 patients patient NOUN dti-1425 70 6 who who PRON dti-1425 70 7 undergo undergo VERB dti-1425 70 8 an an DET dti-1425 70 9 early early ADJ dti-1425 70 10 reoperation reoperation NOUN dti-1425 70 11 for for ADP dti-1425 70 12 bleeding bleed VERB dti-1425 70 13 ( ( PUNCT dti-1425 70 14 or or CCONJ dti-1425 70 15 other other ADJ dti-1425 70 16 reasons reason NOUN dti-1425 70 17 ) ) PUNCT dti-1425 70 18 in in ADP dti-1425 70 19 the the DET dti-1425 70 20 immediate immediate ADJ dti-1425 70 21 postoperative postoperative ADJ dti-1425 70 22 course course NOUN dti-1425 70 23 , , PUNCT dti-1425 70 24 the the DET dti-1425 70 25 risk risk NOUN dti-1425 70 26 of of ADP dti-1425 70 27 a a DET dti-1425 70 28 swi swi NOUN dti-1425 70 29 is be AUX dti-1425 70 30 increased increase VERB dti-1425 70 31 . . PUNCT dti-1425 71 1 in in ADP dti-1425 71 2 their their PRON dti-1425 71 3 prospective prospective ADJ dti-1425 71 4 randomized randomized ADJ dti-1425 71 5 trial trial NOUN dti-1425 71 6 , , PUNCT dti-1425 71 7 friberg friberg PROPN dti-1425 71 8 et et PROPN dti-1425 71 9 al16 al16 PROPN dti-1425 71 10 investigated investigate VERB dti-1425 71 11 the the DET dti-1425 71 12 beneficial beneficial ADJ dti-1425 71 13 effect effect NOUN dti-1425 71 14 of of ADP dti-1425 71 15 gics gic NOUN dti-1425 71 16 in in ADP dti-1425 71 17 2000 2000 NUM dti-1425 71 18 patients patient NOUN dti-1425 71 19 undergoing undergo VERB dti-1425 71 20 cardiac cardiac ADJ dti-1425 71 21 surgery surgery NOUN dti-1425 71 22 ( ( PUNCT dti-1425 71 23 table table NOUN dti-1425 71 24 2 2 NUM dti-1425 71 25 ) ) PUNCT dti-1425 71 26 ; ; PUNCT dti-1425 71 27 their their PRON dti-1425 71 28 results result NOUN dti-1425 71 29 showed show VERB dti-1425 71 30 a a DET dti-1425 71 31 reduced reduced ADJ dti-1425 71 32 incidence incidence NOUN dti-1425 71 33 of of ADP dti-1425 71 34 swi swi NOUN dti-1425 71 35 at at ADP dti-1425 71 36 two two NUM dti-1425 71 37 months month NOUN dti-1425 71 38 in in ADP dti-1425 71 39 the the DET dti-1425 71 40 treatment treatment NOUN dti-1425 71 41 group group NOUN dti-1425 71 42 ( ( PUNCT dti-1425 71 43 4.3 4.3 NUM dti-1425 71 44 % % NOUN dti-1425 71 45 vs vs ADP dti-1425 71 46 9 9 NUM dti-1425 71 47 % % NOUN dti-1425 71 48 , , PUNCT dti-1425 71 49 rr rr PROPN dti-1425 71 50 0.47 0.47 NUM dti-1425 71 51 ; ; PUNCT dti-1425 71 52 95 95 NUM dti-1425 71 53 % % NOUN dti-1425 71 54 confidence confidence NOUN dti-1425 71 55 interval interval NOUN dti-1425 72 1 [ [ X dti-1425 72 2 ci ci X dti-1425 72 3 ] ] X dti-1425 72 4 0.33–0.68 0.33–0.68 NUM dti-1425 72 5 , , PUNCT dti-1425 72 6 p p ADJ dti-1425 72 7     SPACE dti-1425 72 8   NOUN dti-1425 72 9     SPACE dti-1425 72 10 0.001 0.001 NUM dti-1425 72 11 ) ) PUNCT dti-1425 72 12 . . PUNCT dti-1425 73 1 this this DET dti-1425 73 2 result result NOUN dti-1425 73 3 appears appear VERB dti-1425 73 4 to to PART dti-1425 73 5 be be AUX dti-1425 73 6 even even ADV dti-1425 73 7 more more ADV dti-1425 73 8 important important ADJ dti-1425 73 9 if if SCONJ dti-1425 73 10 we we PRON dti-1425 73 11 consider consider VERB dti-1425 73 12 that that SCONJ dti-1425 73 13 the the DET dti-1425 73 14 treatment treatment NOUN dti-1425 73 15 group group NOUN dti-1425 73 16 had have VERB dti-1425 73 17 a a DET dti-1425 73 18 higher high ADJ dti-1425 73 19 number number NOUN dti-1425 73 20 of of ADP dti-1425 73 21 early early ADJ dti-1425 73 22 reoperations reoperation NOUN dti-1425 73 23 for for ADP dti-1425 73 24 bleeding bleed VERB dti-1425 73 25 ( ( PUNCT dti-1425 73 26 4 4 NUM dti-1425 73 27 % % NOUN dti-1425 73 28 vs vs ADP dti-1425 73 29 2.3 2.3 NUM dti-1425 73 30 % % NOUN dti-1425 73 31 , , PUNCT dti-1425 73 32 p p X dti-1425 73 33     SPACE dti-1425 73 34 = = NOUN dti-1425 73 35     SPACE dti-1425 73 36 0.03 0.03 NUM dti-1425 73 37 ) ) PUNCT dti-1425 73 38 , , PUNCT dti-1425 73 39 thus thus ADV dti-1425 73 40 suggesting suggest VERB dti-1425 73 41 that that SCONJ dti-1425 73 42 the the DET dti-1425 73 43 use use NOUN dti-1425 73 44 of of ADP dti-1425 73 45 a a DET dti-1425 73 46 gics gic NOUN dti-1425 73 47 is be AUX dti-1425 73 48 effective effective ADJ dti-1425 73 49 in in ADP dti-1425 73 50 reducing reduce VERB dti-1425 73 51 swi swi NOUN dti-1425 73 52 even even ADV dti-1425 73 53 in in ADP dti-1425 73 54 the the DET dti-1425 73 55 presence presence NOUN dti-1425 73 56 of of ADP dti-1425 73 57 early early ADJ dti-1425 73 58 resternotomy resternotomy NOUN dti-1425 73 59 . . PUNCT dti-1425 74 1 the the DET dti-1425 74 2 authors author NOUN dti-1425 74 3 repeated repeat VERB dti-1425 74 4 their their PRON dti-1425 74 5 analysis analysis NOUN dti-1425 74 6 , , PUNCT dti-1425 74 7 excluding exclude VERB dti-1425 74 8 the the DET dti-1425 74 9 patients patient NOUN dti-1425 74 10 reoperated reoperate VERB dti-1425 74 11 for for ADP dti-1425 74 12 bleeding bleed VERB dti-1425 74 13 ( ( PUNCT dti-1425 74 14 or or CCONJ dti-1425 74 15 other other ADJ dti-1425 74 16 reasons reason NOUN dti-1425 74 17 ) ) PUNCT dti-1425 74 18 and and CCONJ dti-1425 74 19 those those PRON dti-1425 74 20 who who PRON dti-1425 74 21 died die VERB dti-1425 74 22 within within ADP dti-1425 74 23 two two NUM dti-1425 74 24 months month NOUN dti-1425 74 25 ; ; PUNCT dti-1425 74 26 in in ADP dti-1425 74 27 this this DET dti-1425 74 28 subgroup subgroup NOUN dti-1425 74 29 , , PUNCT dti-1425 74 30 there there PRON dti-1425 74 31 was be VERB dti-1425 74 32 still still ADV dti-1425 74 33 a a DET dti-1425 74 34 significantly significantly ADV dti-1425 74 35 lower low ADJ dti-1425 74 36 incidence incidence NOUN dti-1425 74 37 of of ADP dti-1425 74 38 sswis sswis NOUN dti-1425 74 39 ( ( PUNCT dti-1425 74 40 2.5 2.5 NUM dti-1425 74 41 % % NOUN dti-1425 74 42 vs vs ADP dti-1425 74 43 6.7 6.7 NUM dti-1425 74 44 % % NOUN dti-1425 74 45 , , PUNCT dti-1425 74 46 p p X dti-1425 74 47     SPACE dti-1425 74 48 = = NOUN dti-1425 74 49     SPACE dti-1425 74 50 0.001 0.001 NUM dti-1425 74 51 ) ) PUNCT dti-1425 74 52 and and CCONJ dti-1425 74 53 dswis dswis NOUN dti-1425 74 54 ( ( PUNCT dti-1425 74 55 2.1 2.1 NUM dti-1425 74 56 vs vs ADP dti-1425 74 57 3.3 3.3 NUM dti-1425 74 58 % % NOUN dti-1425 74 59 , , PUNCT dti-1425 74 60 p p X dti-1425 74 61     SPACE dti-1425 74 62 = = NOUN dti-1425 74 63     SPACE dti-1425 74 64 0.088 0.088 NUM dti-1425 74 65 ) ) PUNCT dti-1425 74 66 in in ADP dti-1425 74 67 the the DET dti-1425 74 68 gics gic NOUN dti-1425 74 69 group group NOUN dti-1425 74 70 . . PUNCT dti-1425 75 1 in in ADP dti-1425 75 2 2012 2012 NUM dti-1425 75 3 , , PUNCT dti-1425 75 4 creanor creanor NOUN dti-1425 75 5 et et NOUN dti-1425 75 6 al al PROPN dti-1425 75 7 published publish VERB dti-1425 75 8 a a DET dti-1425 75 9 meta meta ADJ dti-1425 75 10 - - PUNCT dti-1425 75 11 analysis analysis NOUN dti-1425 75 12 including include VERB dti-1425 75 13 randomized randomize VERB dti-1425 75 14 controlled control VERB dti-1425 75 15 trials trial NOUN dti-1425 75 16 , , PUNCT dti-1425 75 17 which which PRON dti-1425 75 18 had have AUX dti-1425 75 19 previously previously ADV dti-1425 75 20 investigated investigate VERB dti-1425 75 21 the the DET dti-1425 75 22 use use NOUN dti-1425 75 23 of of ADP dti-1425 75 24 gics gic NOUN dti-1425 75 25 in in ADP dti-1425 75 26 cardiac cardiac ADJ dti-1425 75 27 surgery.36 surgery.36 NOUN dti-1425 75 28 one one NUM dti-1425 75 29 of of ADP dti-1425 75 30 the the DET dti-1425 75 31 subanalyses subanalyse NOUN dti-1425 75 32 of of ADP dti-1425 75 33 this this DET dti-1425 75 34 study study NOUN dti-1425 75 35 was be AUX dti-1425 75 36 conducted conduct VERB dti-1425 75 37 considering consider VERB dti-1425 75 38 high high ADJ dti-1425 75 39 - - PUNCT dti-1425 75 40 risk risk NOUN dti-1425 75 41 patients patient NOUN dti-1425 75 42 ; ; PUNCT dti-1425 75 43 a a DET dti-1425 75 44 statistically statistically ADV dti-1425 75 45 significant significant ADJ dti-1425 75 46 difference difference NOUN dti-1425 75 47 between between ADP dti-1425 75 48 treatment treatment NOUN dti-1425 75 49 and and CCONJ dti-1425 75 50 control control NOUN dti-1425 75 51 group group NOUN dti-1425 75 52 was be AUX dti-1425 75 53 found find VERB dti-1425 75 54 with with ADP dti-1425 75 55 regard regard NOUN dti-1425 75 56 to to ADP dti-1425 75 57 dswis dswis NOUN dti-1425 75 58 ( ( PUNCT dti-1425 75 59 odds odd VERB dti-1425 75 60 ratio ratio NOUN dti-1425 75 61 [ [ X dti-1425 75 62 or or CCONJ dti-1425 75 63 ] ] PUNCT dti-1425 75 64 0.62 0.62 NUM dti-1425 75 65 , , PUNCT dti-1425 75 66 95 95 NUM dti-1425 75 67 % % NOUN dti-1425 75 68 ci ci NOUN dti-1425 75 69 0.39–0.98 0.39–0.98 NUM dti-1425 75 70 ) ) PUNCT dti-1425 75 71 , , PUNCT dti-1425 75 72 while while SCONJ dti-1425 75 73 no no DET dti-1425 75 74 difference difference NOUN dti-1425 75 75 was be AUX dti-1425 75 76 found find VERB dti-1425 75 77 with with ADP dti-1425 75 78 regard regard NOUN dti-1425 75 79 to to ADP dti-1425 75 80 any any DET dti-1425 75 81 swi swi NOUN dti-1425 75 82 ( ( PUNCT dti-1425 75 83 or or CCONJ dti-1425 75 84 0.60 0.60 NUM dti-1425 75 85 , , PUNCT dti-1425 75 86 95 95 NUM dti-1425 75 87 % % NOUN dti-1425 75 88 ci ci NOUN dti-1425 75 89 0.24–1.52).36 0.24–1.52).36 NUM dti-1425 75 90 in in ADP dti-1425 75 91 a a DET dti-1425 75 92 recent recent ADJ dti-1425 75 93 study study NOUN dti-1425 75 94 published publish VERB dti-1425 75 95 in in ADP dti-1425 75 96 2014 2014 NUM dti-1425 75 97 , , PUNCT dti-1425 75 98 benedetto benedetto PROPN dti-1425 75 99 and and CCONJ dti-1425 75 100 raja33 raja33 PROPN dti-1425 75 101 identified identify VERB dti-1425 75 102 the the DET dti-1425 75 103 most most ADV dti-1425 75 104 important important ADJ dti-1425 75 105 risk risk NOUN dti-1425 75 106 factors factor NOUN dti-1425 75 107 for for ADP dti-1425 75 108 dswi dswi ADJ dti-1425 75 109 after after ADP dti-1425 75 110 cardiac cardiac ADJ dti-1425 75 111 surgery surgery NOUN dti-1425 75 112 . . PUNCT dti-1425 76 1 in in ADP dti-1425 76 2 their their PRON dti-1425 76 3 large large ADJ dti-1425 76 4 analysis analysis NOUN dti-1425 76 5 involving involve VERB dti-1425 76 6 8750 8750 NUM dti-1425 76 7 cardiac cardiac ADJ dti-1425 76 8 surgical surgical ADJ dti-1425 76 9 patients patient NOUN dti-1425 76 10 , , PUNCT dti-1425 76 11 the the DET dti-1425 76 12 authors author NOUN dti-1425 76 13 identified identify VERB dti-1425 76 14 several several ADJ dti-1425 76 15 variables variable NOUN dti-1425 76 16 that that PRON dti-1425 76 17 can can AUX dti-1425 76 18 have have VERB dti-1425 76 19 an an DET dti-1425 76 20 impact impact NOUN dti-1425 76 21 on on ADP dti-1425 76 22 the the DET dti-1425 76 23 development development NOUN dti-1425 76 24 of of ADP dti-1425 76 25 this this DET dti-1425 76 26 complication complication NOUN dti-1425 76 27 : : PUNCT dti-1425 76 28 female female ADJ dti-1425 76 29 gender gender NOUN dti-1425 76 30 , , PUNCT dti-1425 76 31 obesity obesity NOUN dti-1425 76 32 , , PUNCT dti-1425 76 33 insulin insulin NOUN dti-1425 76 34 - - PUNCT dti-1425 76 35 dependent dependent ADJ dti-1425 76 36 diabetes diabetes NOUN dti-1425 76 37 , , PUNCT dti-1425 76 38 need need VERB dti-1425 76 39 for for ADP dti-1425 76 40 reexploration reexploration NOUN dti-1425 76 41 , , PUNCT dti-1425 76 42 isolated isolated ADJ dti-1425 76 43 or or CCONJ dti-1425 76 44 combined combine VERB dti-1425 76 45 cabg cabg NOUN dti-1425 76 46 , , PUNCT dti-1425 76 47 and and CCONJ dti-1425 76 48 the the DET dti-1425 76 49 use use NOUN dti-1425 76 50 of of ADP dti-1425 76 51 bilateral bilateral ADJ dti-1425 76 52 mammary mammary ADJ dti-1425 76 53 artery.33 artery.33 PROPN dti-1425 76 54 using use VERB dti-1425 76 55 these these DET dti-1425 76 56 variables variable NOUN dti-1425 76 57 , , PUNCT dti-1425 76 58 the the DET dti-1425 76 59 authors author NOUN dti-1425 76 60 were be AUX dti-1425 76 61 able able ADJ dti-1425 76 62 to to PART dti-1425 76 63 create create VERB dti-1425 76 64 a a DET dti-1425 76 65 risk risk NOUN dti-1425 76 66 score score NOUN dti-1425 76 67 to to PART dti-1425 76 68 guide guide VERB dti-1425 76 69 the the DET dti-1425 76 70 use use NOUN dti-1425 76 71 of of ADP dti-1425 76 72 gics gic NOUN dti-1425 76 73 , , PUNCT dti-1425 76 74 demonstrating demonstrate VERB dti-1425 76 75 that that SCONJ dti-1425 76 76 an an DET dti-1425 76 77 individual individual ADJ dti-1425 76 78 assessment assessment NOUN dti-1425 76 79 of of ADP dti-1425 76 80 dswi dswi ADJ dti-1425 76 81 risk risk NOUN dti-1425 76 82 is be AUX dti-1425 76 83 realizable realizable ADJ dti-1425 76 84 . . PUNCT dti-1425 77 1 patients patient NOUN dti-1425 77 2 were be AUX dti-1425 77 3 classified classify VERB dti-1425 77 4 as as ADP dti-1425 77 5 low low ADJ dti-1425 77 6 , , PUNCT dti-1425 77 7 moderate moderate ADJ dti-1425 77 8 , , PUNCT dti-1425 77 9 or or CCONJ dti-1425 77 10 high high ADJ dti-1425 77 11 risk risk NOUN dti-1425 77 12 for for ADP dti-1425 77 13 dswi dswi NOUN dti-1425 77 14 , , PUNCT dti-1425 77 15 depending depend VERB dti-1425 77 16 on on ADP dti-1425 77 17 their their PRON dti-1425 77 18 baseline baseline ADJ dti-1425 77 19 score score NOUN dti-1425 77 20 ( ( PUNCT dti-1425 77 21 table table NOUN dti-1425 77 22     SPACE dti-1425 77 23 3 3 NUM dti-1425 77 24 and and CCONJ dti-1425 77 25 fig fig NOUN dti-1425 77 26 . . PUNCT dti-1425 77 27     SPACE dti-1425 78 1 2 2 NUM dti-1425 78 2 ) ) PUNCT dti-1425 78 3 . . PUNCT dti-1425 79 1 according accord VERB dti-1425 79 2 to to ADP dti-1425 79 3 the the DET dti-1425 79 4 authors author NOUN dti-1425 79 5 ’ ’ PART dti-1425 79 6 findings finding NOUN dti-1425 79 7 , , PUNCT dti-1425 79 8 the the DET dti-1425 79 9 use use NOUN dti-1425 79 10 of of ADP dti-1425 79 11 gics gic NOUN dti-1425 79 12 allowed allow VERB dti-1425 79 13 to to PART dti-1425 79 14 reclassify reclassify VERB dti-1425 79 15 patients patient NOUN dti-1425 79 16 with with ADP dti-1425 79 17 moderate moderate ADJ dti-1425 79 18 predicted predict VERB dti-1425 79 19 risk risk NOUN dti-1425 79 20 of of ADP dti-1425 79 21 dswi dswi NOUN dti-1425 79 22 in in ADP dti-1425 79 23 the the DET dti-1425 79 24 low low ADJ dti-1425 79 25 - - PUNCT dti-1425 79 26 risk risk NOUN dti-1425 79 27 class class NOUN dti-1425 79 28 . . PUNCT dti-1425 80 1 on on ADP dti-1425 80 2 the the DET dti-1425 80 3 other other ADJ dti-1425 80 4 hand hand NOUN dti-1425 80 5 , , PUNCT dti-1425 80 6 in in ADP dti-1425 80 7 high high ADJ dti-1425 80 8 - - PUNCT dti-1425 80 9 risk risk NOUN dti-1425 80 10 patients patient NOUN dti-1425 80 11 , , PUNCT dti-1425 80 12 the the DET dti-1425 80 13 observed observe VERB dti-1425 80 14 dswi dswi ADJ dti-1425 80 15 incidence incidence NOUN dti-1425 80 16 was be AUX dti-1425 80 17 lower low ADJ dti-1425 80 18 than than SCONJ dti-1425 80 19 expected expect VERB dti-1425 80 20 when when SCONJ dti-1425 80 21 a a DET dti-1425 80 22 gics gic NOUN dti-1425 80 23 was be AUX dti-1425 80 24 implanted implant VERB dti-1425 80 25 , , PUNCT dti-1425 80 26 but but CCONJ dti-1425 80 27 the the DET dti-1425 80 28 authors author NOUN dti-1425 80 29 concluded conclude VERB dti-1425 80 30 that that SCONJ dti-1425 80 31 these these DET dti-1425 80 32 patients patient NOUN dti-1425 80 33 should should AUX dti-1425 80 34 still still ADV dti-1425 80 35 be be AUX dti-1425 80 36 considered consider VERB dti-1425 80 37 at at ADP dti-1425 80 38 higher high ADJ dti-1425 80 39 risk.33 risk.33 NOUN dti-1425 80 40 till till SCONJ dti-1425 80 41 date date NOUN dti-1425 80 42 , , PUNCT dti-1425 80 43 this this DET dti-1425 80 44 score score NOUN dti-1425 80 45 appears appear VERB dti-1425 80 46 to to PART dti-1425 80 47 be be AUX dti-1425 80 48 the the DET dti-1425 80 49 only only ADJ dti-1425 80 50 available available ADJ dti-1425 80 51 guide guide NOUN dti-1425 80 52 in in ADP dti-1425 80 53 the the DET dti-1425 80 54 decisionmaking decisionmake VERB dti-1425 80 55 process process NOUN dti-1425 80 56 for for ADP dti-1425 80 57 the the DET dti-1425 80 58 use use NOUN dti-1425 80 59 of of ADP dti-1425 80 60 gics gic NOUN dti-1425 80 61 in in ADP dti-1425 80 62 cardiac cardiac ADJ dti-1425 80 63 surgery surgery NOUN dti-1425 80 64 . . PUNCT dti-1425 81 1 conclusion conclusion NOUN dti-1425 81 2 gicss gicss PROPN dti-1425 81 3 represent represent VERB dti-1425 81 4 a a DET dti-1425 81 5 promising promise VERB dti-1425 81 6 option option NOUN dti-1425 81 7 to to PART dti-1425 81 8 prevent prevent VERB dti-1425 81 9 the the DET dti-1425 81 10 occurrence occurrence NOUN dti-1425 81 11 of of ADP dti-1425 81 12 swis swis NOUN dti-1425 81 13 after after ADP dti-1425 81 14 heart heart NOUN dti-1425 81 15 surgery surgery NOUN dti-1425 81 16 . . PUNCT dti-1425 82 1 their their PRON dti-1425 82 2 main main ADJ dti-1425 82 3 advantage advantage NOUN dti-1425 82 4 is be AUX dti-1425 82 5 related relate VERB dti-1425 82 6 to to ADP dti-1425 82 7 a a DET dti-1425 82 8 high high ADJ dti-1425 82 9 local local ADJ dti-1425 82 10 concentration concentration NOUN dti-1425 82 11 of of ADP dti-1425 82 12 gentamicin gentamicin NOUN dti-1425 82 13 to to ADP dti-1425 82 14 the the DET dti-1425 82 15 surgical surgical ADJ dti-1425 82 16 site site NOUN dti-1425 82 17 , , PUNCT dti-1425 82 18 combined combine VERB dti-1425 82 19 with with ADP dti-1425 82 20 low low ADJ dti-1425 82 21 serum serum NOUN dti-1425 82 22 levels level NOUN dti-1425 82 23 of of ADP dti-1425 82 24 the the DET dti-1425 82 25 drug drug NOUN dti-1425 82 26 , , PUNCT dti-1425 82 27 thus thus ADV dti-1425 82 28 avoiding avoid VERB dti-1425 82 29 systemic systemic ADJ dti-1425 82 30 side side NOUN dti-1425 82 31 effects effect NOUN dti-1425 82 32 . . PUNCT dti-1425 83 1 most most ADJ dti-1425 83 2 of of ADP dti-1425 83 3 the the DET dti-1425 83 4 current current ADJ dti-1425 83 5 knowledge knowledge NOUN dti-1425 83 6 on on ADP dti-1425 83 7 their their PRON dti-1425 83 8 use use NOUN dti-1425 83 9 in in ADP dti-1425 83 10 cardiac cardiac ADJ dti-1425 83 11 surgery surgery NOUN dti-1425 83 12 derives derive VERB dti-1425 83 13 from from ADP dti-1425 83 14 underpowered underpowered ADJ dti-1425 83 15 studies study NOUN dti-1425 83 16 , , PUNCT dti-1425 83 17 with with ADP dti-1425 83 18 different different ADJ dti-1425 83 19 techniques technique NOUN dti-1425 83 20 of of ADP dti-1425 83 21 application application NOUN dti-1425 83 22 . . PUNCT dti-1425 84 1 hence hence ADV dti-1425 84 2 , , PUNCT dti-1425 84 3 the the DET dti-1425 84 4 real real ADJ dti-1425 84 5 clinical clinical ADJ dti-1425 84 6 beneficial beneficial ADJ dti-1425 84 7 effects effect NOUN dti-1425 84 8 in in ADP dti-1425 84 9 high high ADJ dti-1425 84 10 - - PUNCT dti-1425 84 11 risk risk NOUN dti-1425 84 12 patients patient NOUN dti-1425 84 13 undergoing undergo VERB dti-1425 84 14 cardiac cardiac ADJ dti-1425 84 15 surgery surgery NOUN dti-1425 84 16 have have AUX dti-1425 84 17 not not PART dti-1425 84 18 been be AUX dti-1425 84 19 completely completely ADV dti-1425 84 20 established establish VERB dti-1425 84 21 , , PUNCT dti-1425 84 22 although although SCONJ dti-1425 84 23 there there PRON dti-1425 84 24 seems seem VERB dti-1425 84 25 to to PART dti-1425 84 26 be be AUX dti-1425 84 27 a a DET dti-1425 84 28 tendency tendency NOUN dti-1425 84 29 toward toward ADP dti-1425 84 30 a a DET dti-1425 84 31 reduced reduce VERB dti-1425 84 32 incidence incidence NOUN dti-1425 84 33 of of ADP dti-1425 84 34 swis swis NOUN dti-1425 84 35 with with ADP dti-1425 84 36 their their PRON dti-1425 84 37 use use NOUN dti-1425 84 38 . . PUNCT dti-1425 85 1 this this PRON dti-1425 85 2 is be AUX dti-1425 85 3 particularly particularly ADV dti-1425 85 4 evident evident ADJ dti-1425 85 5 when when SCONJ dti-1425 85 6 the the DET dti-1425 85 7 device device NOUN dti-1425 85 8 is be AUX dti-1425 85 9 not not PART dti-1425 85 10 soaked soak VERB dti-1425 85 11 in in ADP dti-1425 85 12 saline saline ADJ dti-1425 85 13 solution solution NOUN dti-1425 85 14 , , PUNCT dti-1425 85 15 as as SCONJ dti-1425 85 16 the the DET dti-1425 85 17 results result NOUN dti-1425 85 18 appear appear VERB dti-1425 85 19 to to PART dti-1425 85 20 be be AUX dti-1425 85 21 negatively negatively ADV dti-1425 85 22 affected affect VERB dti-1425 85 23 by by ADP dti-1425 85 24 this this DET dti-1425 85 25 maneuver maneuver NOUN dti-1425 85 26 . . PUNCT dti-1425 85 27 table table NOUN dti-1425 86 1 3 3 NUM dti-1425 86 2 . . PUNCT dti-1425 86 3 score score NOUN dti-1425 86 4 to to PART dti-1425 86 5 calculate calculate VERB dti-1425 86 6 dswi dswi ADJ dti-1425 86 7 predicted predict VERB dti-1425 86 8 risk risk NOUN dti-1425 86 9 . . PUNCT dti-1425 87 1 variable variable ADJ dti-1425 87 2 points point NOUN dti-1425 87 3 female female ADJ dti-1425 87 4 gender gender NOUN dti-1425 87 5 26 26 NUM dti-1425 87 6 insulin insulin NOUN dti-1425 87 7 - - PUNCT dti-1425 87 8 dependent dependent ADJ dti-1425 87 9 diabetes diabetes NOUN dti-1425 87 10 mellitus mellitus NOUN dti-1425 87 11 20 20 NUM dti-1425 87 12 cabg cabg ADJ dti-1425 87 13 ( ( PUNCT dti-1425 87 14 isolated isolated ADJ dti-1425 87 15 or or CCONJ dti-1425 87 16 combined combine VERB dti-1425 87 17 ) ) PUNCT dti-1425 87 18 19 19 NUM dti-1425 87 19 bima bima NOUN dti-1425 87 20 harvesting harvesting NOUN dti-1425 87 21 15 15 NUM dti-1425 87 22 need need NOUN dti-1425 87 23 for for ADP dti-1425 87 24 re re NOUN dti-1425 87 25 - - VERB dti-1425 87 26 exploration exploration ADJ dti-1425 87 27 51 51 NUM dti-1425 87 28 bmi bmi NOUN dti-1425 87 29 see see VERB dti-1425 87 30 figure figure NOUN dti-1425 87 31 2 2 NUM dti-1425 87 32 notes note NOUN dti-1425 87 33 : : PUNCT dti-1425 87 34 data datum NOUN dti-1425 87 35 from from ADP dti-1425 87 36 ref ref NOUN dti-1425 87 37 . . PUNCT dti-1425 88 1 33 33 NUM dti-1425 88 2 . . PUNCT dti-1425 89 1 overall overall ADJ dti-1425 89 2 score score NOUN dti-1425 89 3   PROPN dti-1425 89 4 136 136 NUM dti-1425 89 5 : : PUNCT dti-1425 89 6 low low ADJ dti-1425 89 7 risk risk NOUN dti-1425 89 8 of of ADP dti-1425 89 9 dswi dswi NOUN dti-1425 89 10 . . PUNCT dti-1425 90 1 overall overall ADJ dti-1425 90 2 score score NOUN dti-1425 90 3 between between ADP dti-1425 90 4 136 136 NUM dti-1425 90 5 and and CCONJ dti-1425 90 6 199 199 NUM dti-1425 90 7 : : PUNCT dti-1425 90 8 moderate moderate ADJ dti-1425 90 9 risk risk NOUN dti-1425 90 10 of of ADP dti-1425 90 11 dswi dswi NOUN dti-1425 90 12 . . PUNCT dti-1425 91 1 overall overall ADJ dti-1425 91 2 score score NOUN dti-1425 91 3   CCONJ dti-1425 91 4 199 199 NUM dti-1425 91 5 : : PUNCT dti-1425 91 6 high high ADJ dti-1425 91 7 risk risk NOUN dti-1425 91 8 of of ADP dti-1425 91 9 dswi dswi NOUN dti-1425 91 10 . . PUNCT dti-1425 92 1 abbreviations abbreviation NOUN dti-1425 92 2 : : PUNCT dti-1425 92 3 cabg cabg VERB dti-1425 92 4 , , PUNCT dti-1425 92 5 coronary coronary ADJ dti-1425 92 6 artery artery NOUN dti-1425 92 7 bypass bypass NOUN dti-1425 92 8 grafting grafting NOUN dti-1425 92 9 ; ; PUNCT dti-1425 92 10 bmi bmi PROPN dti-1425 92 11 , , PUNCT dti-1425 92 12 body body NOUN dti-1425 92 13 mass mass PROPN dti-1425 92 14 index index NOUN dti-1425 92 15 . . PUNCT dti-1425 93 1 http://www.la-press.com http://www.la-press.com X dti-1425 94 1 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1425 94 2 effectiveness effectiveness NOUN dti-1425 94 3 of of ADP dti-1425 94 4 gentamicin gentamicin NOUN dti-1425 94 5 - - PUNCT dti-1425 94 6 impregnated impregnate VERB dti-1425 94 7 collagen collagen NOUN dti-1425 94 8 sponge sponge NOUN dti-1425 94 9 13drug 13drug NUM dti-1425 94 10 target target VERB dti-1425 94 11 insights insight NOUN dti-1425 94 12 2016:10(s1 2016:10(s1 NUM dti-1425 94 13 ) ) PUNCT dti-1425 94 14 currently currently ADV dti-1425 94 15 , , PUNCT dti-1425 94 16 there there PRON dti-1425 94 17 are be VERB dti-1425 94 18 no no DET dti-1425 94 19 guidelines guideline NOUN dti-1425 94 20 on on ADP dti-1425 94 21 the the DET dti-1425 94 22 use use NOUN dti-1425 94 23 of of ADP dti-1425 94 24 gics gic NOUN dti-1425 94 25 in in ADP dti-1425 94 26 cardiac cardiac ADJ dti-1425 94 27 surgery surgery NOUN dti-1425 94 28 ; ; PUNCT dti-1425 94 29 the the DET dti-1425 94 30 scoring scoring NOUN dti-1425 94 31 system system NOUN dti-1425 94 32 , , PUNCT dti-1425 94 33 proposed propose VERB dti-1425 94 34 by by ADP dti-1425 94 35 benedetto benedetto PROPN dti-1425 94 36 and and CCONJ dti-1425 94 37 raja,33 raja,33 NOUN dti-1425 94 38 seems seem VERB dti-1425 94 39 to to PART dti-1425 94 40 be be AUX dti-1425 94 41 the the DET dti-1425 94 42 most most ADV dti-1425 94 43 reliable reliable ADJ dti-1425 94 44 tool tool NOUN dti-1425 94 45 presently presently ADV dti-1425 94 46 available available ADJ dti-1425 94 47 for for ADP dti-1425 94 48 the the DET dti-1425 94 49 indication indication NOUN dti-1425 94 50 of of ADP dti-1425 94 51 their their PRON dti-1425 94 52 use use NOUN dti-1425 94 53 in in ADP dti-1425 94 54 high high ADJ dti-1425 94 55 - - PUNCT dti-1425 94 56 risk risk NOUN dti-1425 94 57 patients patient NOUN dti-1425 94 58 . . PUNCT dti-1425 95 1 however however ADV dti-1425 95 2 , , PUNCT dti-1425 95 3 further far ADV dti-1425 95 4 prospective prospective ADJ dti-1425 95 5 randomized randomize VERB dti-1425 95 6 controlled control VERB dti-1425 95 7 trials trial NOUN dti-1425 95 8 , , PUNCT dti-1425 95 9 particularly particularly ADV dti-1425 95 10 in in ADP dti-1425 95 11 high high ADJ dti-1425 95 12 - - PUNCT dti-1425 95 13 risk risk NOUN dti-1425 95 14 patients patient NOUN dti-1425 95 15 , , PUNCT dti-1425 95 16 are be AUX dti-1425 95 17 needed need VERB dti-1425 95 18 to to PART dti-1425 95 19 better well ADV dti-1425 95 20 clarify clarify VERB dti-1425 95 21 the the DET dti-1425 95 22 impact impact NOUN dti-1425 95 23 of of ADP dti-1425 95 24 gics gic NOUN dti-1425 95 25 in in ADP dti-1425 95 26 preventing prevent VERB dti-1425 95 27 swis swis NOUN dti-1425 95 28 . . PUNCT dti-1425 96 1 author author NOUN dti-1425 96 2 contributions contribution NOUN dti-1425 96 3 conceived conceive VERB dti-1425 96 4 the the DET dti-1425 96 5 concepts concept NOUN dti-1425 96 6 : : PUNCT dti-1425 97 1 fr fr PROPN dti-1425 97 2 and and CCONJ dti-1425 97 3 vdb vdb VERB dti-1425 97 4 . . PROPN dti-1425 97 5 wrote write VERB dti-1425 97 6 the the DET dti-1425 97 7 first first ADJ dti-1425 97 8 draft draft NOUN dti-1425 97 9 of of ADP dti-1425 97 10 the the DET dti-1425 97 11 manuscript manuscript NOUN dti-1425 97 12 : : PUNCT dti-1425 97 13 fr fr PROPN dti-1425 97 14 , , PUNCT dti-1425 97 15 vdb vdb NOUN dti-1425 97 16 , , PUNCT dti-1425 97 17 and and CCONJ dti-1425 97 18 cz cz NOUN dti-1425 97 19 . . PROPN dti-1425 97 20 contributed contribute VERB dti-1425 97 21 to to ADP dti-1425 97 22 the the DET dti-1425 97 23 writing writing NOUN dti-1425 97 24 of of ADP dti-1425 97 25 the the DET dti-1425 97 26 manuscript manuscript NOUN dti-1425 97 27 : : PUNCT dti-1425 97 28 pc pc NOUN dti-1425 97 29 , , PUNCT dti-1425 97 30 gg gg NOUN dti-1425 97 31 , , PUNCT dti-1425 97 32 and and CCONJ dti-1425 97 33 rm rm PROPN dti-1425 97 34 . . PROPN dti-1425 98 1 agreed agree VERB dti-1425 98 2 with with ADP dti-1425 98 3 manuscript manuscript NOUN dti-1425 98 4 results result NOUN dti-1425 98 5 and and CCONJ dti-1425 98 6 conclusions conclusion NOUN dti-1425 98 7 : : PUNCT dti-1425 99 1 fr fr ADJ dti-1425 99 2 , , PUNCT dti-1425 99 3 cz cz NOUN dti-1425 99 4 , , PUNCT dti-1425 99 5 gg gg PROPN dti-1425 99 6 , , PUNCT dti-1425 99 7 rm rm PROPN dti-1425 99 8 , , PUNCT dti-1425 99 9 pc pc NOUN dti-1425 99 10 , , PUNCT dti-1425 99 11 and and CCONJ dti-1425 99 12 vdb vdb NOUN dti-1425 99 13 . . PUNCT dti-1425 100 1 jointly jointly ADV dti-1425 100 2 developed develop VERB dti-1425 100 3 the the DET dti-1425 100 4 structure structure NOUN dti-1425 100 5 and and CCONJ dti-1425 100 6 arguments argument NOUN dti-1425 100 7 for for ADP dti-1425 100 8 the the DET dti-1425 100 9 paper paper NOUN dti-1425 100 10 : : PUNCT dti-1425 100 11 fr fr ADJ dti-1425 100 12 , , PUNCT dti-1425 100 13 cz cz NOUN dti-1425 100 14 , , PUNCT dti-1425 100 15 gg gg PROPN dti-1425 100 16 , , PUNCT dti-1425 100 17 rm rm PROPN dti-1425 100 18 , , PUNCT dti-1425 100 19 pc pc NOUN dti-1425 100 20 , , PUNCT dti-1425 100 21 and and CCONJ dti-1425 100 22 vdb vdb NOUN dti-1425 100 23 . . PUNCT dti-1425 101 1 made make VERB dti-1425 101 2 critical critical ADJ dti-1425 101 3 revisions revision NOUN dti-1425 101 4 and and CCONJ dti-1425 101 5 approved approve VERB dti-1425 101 6 the the DET dti-1425 101 7 final final ADJ dti-1425 101 8 version version NOUN dti-1425 101 9 : : PUNCT dti-1425 101 10 fr fr ADJ dti-1425 101 11 , , PUNCT dti-1425 101 12 cz cz NOUN dti-1425 101 13 , , PUNCT dti-1425 101 14 gg gg PROPN dti-1425 101 15 , , PUNCT dti-1425 101 16 rm rm PROPN dti-1425 101 17 , , PUNCT dti-1425 101 18 pc pc NOUN dti-1425 101 19 , , PUNCT dti-1425 101 20 and and CCONJ dti-1425 101 21 vdb vdb VERB dti-1425 101 22 . . PUNCT dti-1425 102 1 all all DET dti-1425 102 2 the the DET dti-1425 102 3 authors author NOUN dti-1425 102 4 reviewed review VERB dti-1425 102 5 and and CCONJ dti-1425 102 6 approved approve VERB dti-1425 102 7 the the DET dti-1425 102 8 final final ADJ dti-1425 102 9 manuscript manuscript NOUN dti-1425 102 10 . . PUNCT dti-1425 103 1 references reference NOUN dti-1425 103 2 1 1 NUM dti-1425 103 3 . . PUNCT dti-1425 103 4 mauermann mauermann PROPN dti-1425 103 5 wj wj PROPN dti-1425 103 6 , , PUNCT dti-1425 103 7 sampathkumar sampathkumar PROPN dti-1425 103 8 p p NOUN dti-1425 103 9 , , PUNCT dti-1425 103 10 thompson thompson PROPN dti-1425 103 11 rl rl PROPN dti-1425 103 12 . . PROPN dti-1425 103 13 sternal sternal ADJ dti-1425 103 14 wound wound NOUN dti-1425 103 15 infections infection NOUN dti-1425 103 16 . . PUNCT dti-1425 104 1 best good ADJ dti-1425 104 2 pract pract PROPN dti-1425 104 3 res res PROPN dti-1425 104 4 clin clin PROPN dti-1425 104 5 anaesthesiol anaesthesiol PROPN dti-1425 104 6 . . PUNCT dti-1425 105 1 2008;22(3):423–436 2008;22(3):423–436 NUM dti-1425 105 2 . . PROPN dti-1425 105 3 2 2 NUM dti-1425 105 4 . . X dti-1425 105 5 tang tang PROPN dti-1425 105 6 ghl ghl PROPN dti-1425 105 7 , , PUNCT dti-1425 105 8 maganti maganti PROPN dti-1425 105 9 m m PROPN dti-1425 105 10 , , PUNCT dti-1425 105 11 weisel weisel PROPN dti-1425 105 12 rd rd PROPN dti-1425 105 13 , , PUNCT dti-1425 105 14 borger borger PROPN dti-1425 105 15 ma ma PROPN dti-1425 105 16 . . PROPN dti-1425 105 17 prevention prevention PROPN dti-1425 105 18 and and CCONJ dti-1425 105 19 management management NOUN dti-1425 105 20 of of ADP dti-1425 105 21 deep deep ADJ dti-1425 105 22 sternal sternal ADJ dti-1425 105 23 wound wound NOUN dti-1425 105 24 infection infection NOUN dti-1425 105 25 . . PUNCT dti-1425 106 1 semin semin PROPN dti-1425 106 2 thorac thorac PROPN dti-1425 106 3 cardiovasc cardiovasc PROPN dti-1425 106 4 surg surg PROPN dti-1425 106 5 . . PUNCT dti-1425 107 1 2004;16(1):62–69 2004;16(1):62–69 X dti-1425 107 2 . . NOUN dti-1425 107 3 3 3 NUM dti-1425 107 4 . . X dti-1425 107 5 mavros mavros PROPN dti-1425 107 6 mn mn PROPN dti-1425 107 7 , , PUNCT dti-1425 107 8 mitsikostas mitsikostas PROPN dti-1425 107 9 pk pk NOUN dti-1425 107 10 , , PUNCT dti-1425 107 11 alexiou alexiou NOUN dti-1425 107 12 vg vg NOUN dti-1425 107 13 , , PUNCT dti-1425 107 14 peppas peppa VERB dti-1425 107 15 g g ADP dti-1425 107 16 , , PUNCT dti-1425 107 17 falagas falagas VERB dti-1425 107 18 me i PRON dti-1425 107 19 . . PUNCT dti-1425 108 1 gentamicin gentamicin NOUN dti-1425 108 2 collagen collagen NOUN dti-1425 108 3 sponges sponge NOUN dti-1425 108 4 for for ADP dti-1425 108 5 the the DET dti-1425 108 6 prevention prevention NOUN dti-1425 108 7 of of ADP dti-1425 108 8 sternal sternal ADJ dti-1425 108 9 wound wound NOUN dti-1425 108 10 infection infection NOUN dti-1425 108 11 : : PUNCT dti-1425 108 12 a a DET dti-1425 108 13 meta meta ADJ dti-1425 108 14 - - PUNCT dti-1425 108 15 analysis analysis NOUN dti-1425 108 16 of of ADP dti-1425 108 17 randomized randomized ADJ dti-1425 108 18 controlled control VERB dti-1425 108 19 trials trial NOUN dti-1425 108 20 . . PUNCT dti-1425 109 1 j j PROPN dti-1425 109 2 thorac thorac PROPN dti-1425 109 3 cardiovasc cardiovasc PROPN dti-1425 109 4 surg surg PROPN dti-1425 109 5 . . PUNCT dti-1425 110 1 2012;144(5):1235–1240 2012;144(5):1235–1240 NUM dti-1425 110 2 . . NOUN dti-1425 111 1 4 4 NUM dti-1425 111 2 . . X dti-1425 111 3 abboud abboud PROPN dti-1425 111 4 cs cs PROPN dti-1425 111 5 , , PUNCT dti-1425 111 6 wey wey PROPN dti-1425 111 7 sb sb PROPN dti-1425 111 8 , , PUNCT dti-1425 111 9 baltar baltar PROPN dti-1425 111 10 vt vt PROPN dti-1425 111 11 . . PROPN dti-1425 111 12 risk risk NOUN dti-1425 111 13 factors factor NOUN dti-1425 111 14 for for ADP dti-1425 111 15 mediastinitis mediastinitis NOUN dti-1425 111 16 after after ADP dti-1425 111 17 cardiac cardiac ADJ dti-1425 111 18 surgery surgery NOUN dti-1425 111 19 . . PUNCT dti-1425 112 1 ann ann PROPN dti-1425 112 2 thorac thorac PROPN dti-1425 112 3 surg surg NOUN dti-1425 112 4 . . PUNCT dti-1425 113 1 2004;77(2):676–683 2004;77(2):676–683 X dti-1425 113 2 . . PUNCT dti-1425 114 1 5 5 X dti-1425 114 2 . . X dti-1425 114 3 lador lador PROPN dti-1425 114 4 a a PROPN dti-1425 114 5 , , PUNCT dti-1425 114 6 nasir nasir PROPN dti-1425 114 7 h h PROPN dti-1425 114 8 , , PUNCT dti-1425 114 9 mansur mansur PROPN dti-1425 114 10 n n CCONJ dti-1425 114 11 , , PUNCT dti-1425 114 12 et et PROPN dti-1425 114 13 al al PROPN dti-1425 114 14 . . PUNCT dti-1425 115 1 antibiotic antibiotic ADJ dti-1425 115 2 prophylaxis prophylaxis NOUN dti-1425 115 3 in in ADP dti-1425 115 4 cardiac cardiac ADJ dti-1425 115 5 surgery surgery NOUN dti-1425 115 6 : : PUNCT dti-1425 115 7 systematic systematic ADJ dti-1425 115 8 review review NOUN dti-1425 115 9 and and CCONJ dti-1425 115 10 meta meta ADJ dti-1425 115 11 - - PUNCT dti-1425 115 12 analysis analysis NOUN dti-1425 115 13 . . PUNCT dti-1425 116 1 j j PROPN dti-1425 116 2 antimicrob antimicrob PROPN dti-1425 116 3 chemother chemother PROPN dti-1425 116 4 . . PUNCT dti-1425 117 1 2012;67(3):541–550 2012;67(3):541–550 NUM dti-1425 117 2 . . PUNCT dti-1425 118 1 6 6 NUM dti-1425 118 2 . . PUNCT dti-1425 119 1 mishra mishra PROPN dti-1425 119 2 p p PROPN dti-1425 119 3 , , PUNCT dti-1425 119 4 ashoub ashoub ADV dti-1425 119 5 a a PRON dti-1425 119 6 , , PUNCT dti-1425 119 7 salhiyyah salhiyyah PROPN dti-1425 119 8 k k NOUN dti-1425 119 9 , , PUNCT dti-1425 119 10 et et PROPN dti-1425 119 11 al al PROPN dti-1425 119 12 . . PROPN dti-1425 119 13 role role NOUN dti-1425 119 14 of of ADP dti-1425 119 15 topical topical ADJ dti-1425 119 16 application application NOUN dti-1425 119 17 of of ADP dti-1425 119 18 gentamicin gentamicin NOUN dti-1425 119 19 containing contain VERB dti-1425 119 20 collagen collagen NOUN dti-1425 119 21 implants implant NOUN dti-1425 119 22 in in ADP dti-1425 119 23 cardiac cardiac ADJ dti-1425 119 24 surgery surgery NOUN dti-1425 119 25 . . PUNCT dti-1425 120 1 j j PROPN dti-1425 120 2 cardiothorac cardiothorac PROPN dti-1425 120 3 surg surg PROPN dti-1425 120 4 . . PUNCT dti-1425 121 1 2014 2014 NUM dti-1425 121 2 ; ; PUNCT dti-1425 122 1 9(1):122 9(1):122 NUM dti-1425 122 2 . . NOUN dti-1425 123 1 7 7 X dti-1425 123 2 . . X dti-1425 123 3 beckmann beckmann PROPN dti-1425 123 4 a a PROPN dti-1425 123 5 , , PUNCT dti-1425 123 6 doebler doebler NOUN dti-1425 123 7 k k PROPN dti-1425 123 8 , , PUNCT dti-1425 123 9 schaefer schaefer PROPN dti-1425 123 10 e e PROPN dti-1425 123 11 , , PUNCT dti-1425 123 12 koetting koette VERB dti-1425 123 13 j j PROPN dti-1425 123 14 , , PUNCT dti-1425 123 15 gastmeier gastmeier AUX dti-1425 123 16 p p NOUN dti-1425 123 17 , , PUNCT dti-1425 123 18 graf graf PROPN dti-1425 123 19 k. k. PROPN dti-1425 124 1 sternal sternal ADJ dti-1425 124 2 surgical surgical ADJ dti-1425 124 3 site site NOUN dti-1425 124 4 infection infection NOUN dti-1425 124 5 prevention prevention NOUN dti-1425 124 6 — — PUNCT dti-1425 124 7 is be AUX dti-1425 124 8 there there PRON dti-1425 124 9 any any DET dti-1425 124 10 room room NOUN dti-1425 124 11 for for ADP dti-1425 124 12 improvement improvement NOUN dti-1425 124 13 ? ? PUNCT dti-1425 125 1 eur eur PROPN dti-1425 125 2 j j PROPN dti-1425 125 3 cardiothorac cardiothorac PROPN dti-1425 125 4 surg surg PROPN dti-1425 125 5 . . PUNCT dti-1425 126 1 2011;40(2):347–351 2011;40(2):347–351 X dti-1425 126 2 . . X dti-1425 126 3 8 8 NUM dti-1425 126 4 . . PUNCT dti-1425 126 5 ruszczak ruszczak PROPN dti-1425 126 6 z z PROPN dti-1425 126 7 , , PUNCT dti-1425 126 8 friess friess PROPN dti-1425 126 9 w. w. PROPN dti-1425 126 10 collagen collagen PROPN dti-1425 126 11 as as ADP dti-1425 126 12 a a DET dti-1425 126 13 carrier carrier NOUN dti-1425 126 14 for for ADP dti-1425 126 15 on on ADP dti-1425 126 16 - - PUNCT dti-1425 126 17 site site NOUN dti-1425 126 18 delivery delivery NOUN dti-1425 126 19 of of ADP dti-1425 126 20 antibacterial antibacterial ADJ dti-1425 126 21 drugs drug NOUN dti-1425 126 22 . . PUNCT dti-1425 127 1 adv adv PROPN dti-1425 127 2 drug drug PROPN dti-1425 127 3 deliv deliv PROPN dti-1425 127 4 rev rev VERB dti-1425 127 5 . . PUNCT dti-1425 128 1 2003;55(12):1679–1698 2003;55(12):1679–1698 NUM dti-1425 128 2 . . PUNCT dti-1425 129 1 9 9 X dti-1425 129 2 . . X dti-1425 129 3 horan horan PROPN dti-1425 129 4 tc tc PROPN dti-1425 129 5 , , PUNCT dti-1425 129 6 andrus andrus PROPN dti-1425 129 7 m m PROPN dti-1425 129 8 , , PUNCT dti-1425 129 9 dudeck dudeck PROPN dti-1425 129 10 ma ma PROPN dti-1425 129 11 . . PUNCT dti-1425 130 1 cdc cdc PROPN dti-1425 130 2 / / SYM dti-1425 130 3 nhsn nhsn PROPN dti-1425 130 4 surveillance surveillance NOUN dti-1425 130 5 definition definition NOUN dti-1425 130 6 of of ADP dti-1425 130 7 health health NOUN dti-1425 130 8 care care NOUN dti-1425 130 9 - - PUNCT dti-1425 130 10 associated associate VERB dti-1425 130 11 infection infection NOUN dti-1425 130 12 and and CCONJ dti-1425 130 13 criteria criterion NOUN dti-1425 130 14 for for ADP dti-1425 130 15 specific specific ADJ dti-1425 130 16 types type NOUN dti-1425 130 17 of of ADP dti-1425 130 18 infections infection NOUN dti-1425 130 19 in in ADP dti-1425 130 20 the the DET dti-1425 130 21 acute acute NOUN dti-1425 130 22 care care NOUN dti-1425 130 23 setting setting NOUN dti-1425 130 24 . . PUNCT dti-1425 131 1 am be AUX dti-1425 131 2 j j PROPN dti-1425 131 3 infect infect PROPN dti-1425 131 4 control control NOUN dti-1425 131 5 . . PUNCT dti-1425 132 1 2008;36(5):309–332 2008;36(5):309–332 X dti-1425 132 2 . . NOUN dti-1425 132 3 10 10 NUM dti-1425 132 4 . . PUNCT dti-1425 132 5 national national PROPN dti-1425 132 6 institute institute PROPN dti-1425 132 7 for for ADP dti-1425 132 8 health health NOUN dti-1425 132 9 and and CCONJ dti-1425 132 10 clinical clinical ADJ dti-1425 132 11 excellence excellence NOUN dti-1425 132 12 . . PUNCT dti-1425 133 1 nice nice ADJ dti-1425 133 2 clinical clinical ADJ dti-1425 133 3 guideline guideline NOUN dti-1425 133 4 74 74 NUM dti-1425 133 5 : : PUNCT dti-1425 133 6 surgical surgical ADJ dti-1425 133 7 site site NOUN dti-1425 133 8 infection infection NOUN dti-1425 133 9 . . PUNCT dti-1425 134 1 national national PROPN dti-1425 134 2 institute institute PROPN dti-1425 134 3 for for ADP dti-1425 134 4 health health NOUN dti-1425 134 5 and and CCONJ dti-1425 134 6 clinical clinical ADJ dti-1425 134 7 excellence excellence PROPN dti-1425 134 8 , , PUNCT dti-1425 134 9 manchester manchester PROPN dti-1425 134 10 , , PUNCT dti-1425 134 11 united united ADJ dti-1425 134 12 kingdom kingdom PROPN dti-1425 134 13 ; ; PUNCT dti-1425 134 14 2008:1–31 2008:1–31 NUM dti-1425 134 15 . . PROPN dti-1425 134 16 11 11 NUM dti-1425 134 17 . . PUNCT dti-1425 135 1 gårdlund gårdlund PROPN dti-1425 135 2 b b PROPN dti-1425 135 3 , , PUNCT dti-1425 135 4 bitkover bitkover PROPN dti-1425 135 5 cy cy PROPN dti-1425 135 6 , , PUNCT dti-1425 135 7 vaage vaage NOUN dti-1425 135 8 j. j. PROPN dti-1425 135 9 postoperative postoperative ADJ dti-1425 135 10 mediastinitis mediastinitis PROPN dti-1425 135 11 in in ADP dti-1425 135 12 cardiac cardiac ADJ dti-1425 135 13 surgery surgery NOUN dti-1425 135 14 — — PUNCT dti-1425 135 15 microbiology microbiology NOUN dti-1425 135 16 and and CCONJ dti-1425 135 17 pathogenesis pathogenesis NOUN dti-1425 135 18 . . PUNCT dti-1425 136 1 eur eur PROPN dti-1425 136 2 j j PROPN dti-1425 136 3 cardiothorac cardiothorac PROPN dti-1425 136 4 surg surg PROPN dti-1425 136 5 . . PUNCT dti-1425 137 1 2002;21(5):825–830 2002;21(5):825–830 NUM dti-1425 137 2 . . PUNCT dti-1425 138 1 12 12 NUM dti-1425 138 2 . . PUNCT dti-1425 139 1 charbonneau charbonneau PROPN dti-1425 139 2 h h PROPN dti-1425 139 3 , , PUNCT dti-1425 139 4 maillet maillet PROPN dti-1425 139 5 jm jm PROPN dti-1425 139 6 , , PUNCT dti-1425 139 7 faron faron PROPN dti-1425 139 8 m m PROPN dti-1425 139 9 , , PUNCT dti-1425 139 10 et et PROPN dti-1425 139 11 al al PROPN dti-1425 139 12 . . PUNCT dti-1425 139 13 mediastinitis mediastinitis PROPN dti-1425 139 14 due due ADP dti-1425 139 15 to to ADP dti-1425 139 16 gram gram NOUN dti-1425 139 17 - - PUNCT dti-1425 139 18 negative negative ADJ dti-1425 139 19 bacteria bacteria NOUN dti-1425 139 20 is be AUX dti-1425 139 21 associated associate VERB dti-1425 139 22 with with ADP dti-1425 139 23 increased increase VERB dti-1425 139 24 mortality mortality NOUN dti-1425 139 25 . . PUNCT dti-1425 140 1 clin clin PROPN dti-1425 140 2 microbiol microbiol PROPN dti-1425 140 3 infect infect VERB dti-1425 140 4 . . PUNCT dti-1425 141 1 2013;20(3 2013;20(3 NUM dti-1425 141 2 ): ): PUNCT dti-1425 141 3 o197 o197 PROPN dti-1425 141 4 – – PUNCT dti-1425 141 5 o202 o202 PROPN dti-1425 141 6 . . PROPN dti-1425 142 1 13 13 NUM dti-1425 142 2 . . PUNCT dti-1425 143 1 friberg friberg PROPN dti-1425 143 2 ö ö PROPN dti-1425 143 3 , , PUNCT dti-1425 143 4 dahlin dahlin PROPN dti-1425 143 5 l l PROPN dti-1425 143 6 - - NOUN dti-1425 143 7 g g PROPN dti-1425 143 8 , , PUNCT dti-1425 143 9 källman källman PROPN dti-1425 143 10 j j PROPN dti-1425 143 11 , , PUNCT dti-1425 143 12 kihlström kihlström NOUN dti-1425 143 13 e e NOUN dti-1425 143 14 , , PUNCT dti-1425 143 15 söderquist söderquist NOUN dti-1425 143 16 b b NOUN dti-1425 143 17 , , PUNCT dti-1425 143 18 svedjeholm svedjeholm PROPN dti-1425 143 19 r. r. PROPN dti-1425 143 20 collagen collagen PROPN dti-1425 143 21 - - PUNCT dti-1425 143 22 gentamicin gentamicin VERB dti-1425 143 23 implant implant NOUN dti-1425 143 24 for for ADP dti-1425 143 25 prevention prevention NOUN dti-1425 143 26 of of ADP dti-1425 143 27 sternal sternal ADJ dti-1425 143 28 wound wound NOUN dti-1425 143 29 infection infection NOUN dti-1425 143 30 ; ; PUNCT dti-1425 143 31 longterm longterm VERB dti-1425 143 32 follow follow NOUN dti-1425 143 33 - - PUNCT dti-1425 143 34 up up NOUN dti-1425 143 35 of of ADP dti-1425 143 36 effectiveness effectiveness NOUN dti-1425 143 37 . . PUNCT dti-1425 144 1 interact interact PROPN dti-1425 144 2 cardiovasc cardiovasc PROPN dti-1425 144 3 thorac thorac PROPN dti-1425 144 4 surg surg NOUN dti-1425 144 5 . . PUNCT dti-1425 145 1 2009;9(3 2009;9(3 NUM dti-1425 145 2 ): ): PUNCT dti-1425 146 1 454–458 454–458 NUM dti-1425 146 2 . . PUNCT dti-1425 147 1 14 14 NUM dti-1425 147 2 . . PUNCT dti-1425 148 1 lepelletier lepelletier PROPN dti-1425 148 2 d d PROPN dti-1425 148 3 , , PUNCT dti-1425 148 4 bourigault bourigault PROPN dti-1425 148 5 c c NOUN dti-1425 148 6 , , PUNCT dti-1425 148 7 roussel roussel PROPN dti-1425 148 8 jc jc PROPN dti-1425 148 9 , , PUNCT dti-1425 148 10 et et PROPN dti-1425 148 11 al al PROPN dti-1425 148 12 . . PUNCT dti-1425 149 1 epidemiology epidemiology NOUN dti-1425 149 2 and and CCONJ dti-1425 149 3 prevention prevention NOUN dti-1425 149 4 of of ADP dti-1425 149 5 surgical surgical ADJ dti-1425 149 6 site site NOUN dti-1425 149 7 infections infection NOUN dti-1425 149 8 after after ADP dti-1425 149 9 cardiac cardiac ADJ dti-1425 149 10 surgery surgery NOUN dti-1425 149 11 . . PUNCT dti-1425 150 1 méd méd X dti-1425 150 2 mal mal ADJ dti-1425 150 3 infect infect VERB dti-1425 150 4 . . PUNCT dti-1425 151 1 2013;43(10 2013;43(10 NUM dti-1425 151 2 ): ): PUNCT dti-1425 151 3 403–409 403–409 NUM dti-1425 151 4 . . NOUN dti-1425 151 5 15 15 NUM dti-1425 151 6 . . PUNCT dti-1425 152 1 filsoufi filsoufi NOUN dti-1425 152 2 f f PROPN dti-1425 152 3 , , PUNCT dti-1425 152 4 castillo castillo PROPN dti-1425 152 5 jg jg PROPN dti-1425 152 6 , , PUNCT dti-1425 152 7 rahmanian rahmanian PROPN dti-1425 152 8 pb pb PROPN dti-1425 152 9 , , PUNCT dti-1425 152 10 et et PROPN dti-1425 152 11 al al PROPN dti-1425 152 12 . . PUNCT dti-1425 153 1 epidemiology epidemiology NOUN dti-1425 153 2 of of ADP dti-1425 153 3 deep deep ADJ dti-1425 153 4 sternal sternal ADJ dti-1425 153 5 wound wound NOUN dti-1425 153 6 infection infection NOUN dti-1425 153 7 in in ADP dti-1425 153 8 cardiac cardiac ADJ dti-1425 153 9 surgery surgery NOUN dti-1425 153 10 . . PUNCT dti-1425 154 1 j j PROPN dti-1425 154 2 cardiothorac cardiothorac PROPN dti-1425 154 3 vasc vasc PROPN dti-1425 154 4 anesth anesth PROPN dti-1425 154 5 . . PUNCT dti-1425 155 1 2009;23(4):488–494 2009;23(4):488–494 NUM dti-1425 155 2 . . NOUN dti-1425 155 3 16 16 NUM dti-1425 155 4 . . PUNCT dti-1425 156 1 friberg friberg PROPN dti-1425 156 2 ö ö PROPN dti-1425 156 3 , , PUNCT dti-1425 156 4 svedjeholm svedjeholm NOUN dti-1425 156 5 r r NOUN dti-1425 156 6 , , PUNCT dti-1425 156 7 söderquist söderquist NOUN dti-1425 156 8 b b NOUN dti-1425 156 9 , , PUNCT dti-1425 156 10 granfeldt granfeldt PROPN dti-1425 156 11 h h NOUN dti-1425 156 12 , , PUNCT dti-1425 156 13 vikerfors vikerfors PROPN dti-1425 156 14 t t PROPN dti-1425 156 15 , , PUNCT dti-1425 156 16 källman källman PROPN dti-1425 156 17 j. j. PROPN dti-1425 156 18 local local ADJ dti-1425 156 19 gentamicin gentamicin NOUN dti-1425 156 20 reduces reduce VERB dti-1425 156 21 sternal sternal ADJ dti-1425 156 22 wound wound NOUN dti-1425 156 23 infections infection NOUN dti-1425 156 24 after after ADP dti-1425 156 25 cardiac cardiac ADJ dti-1425 156 26 surgery surgery NOUN dti-1425 156 27 : : PUNCT dti-1425 156 28 a a DET dti-1425 156 29 randomized randomized ADJ dti-1425 156 30 controlled control VERB dti-1425 156 31 trial trial NOUN dti-1425 156 32 . . PUNCT dti-1425 157 1 ann ann PROPN dti-1425 157 2 thorac thorac PROPN dti-1425 157 3 surg surg NOUN dti-1425 157 4 . . PUNCT dti-1425 158 1 2005;79(1):153–161 2005;79(1):153–161 NUM dti-1425 158 2 ; ; PUNCT dti-1425 158 3 discussion discussion NOUN dti-1425 158 4 161–162 161–162 NUM dti-1425 158 5 . . PUNCT dti-1425 159 1 17 17 NUM dti-1425 159 2 . . PUNCT dti-1425 160 1 darouiche darouiche PROPN dti-1425 160 2 ro ro PROPN dti-1425 160 3 . . PROPN dti-1425 160 4 treatment treatment NOUN dti-1425 160 5 of of ADP dti-1425 160 6 infections infection NOUN dti-1425 160 7 associated associate VERB dti-1425 160 8 with with ADP dti-1425 160 9 surgical surgical ADJ dti-1425 160 10 implants implant NOUN dti-1425 160 11 . . PUNCT dti-1425 161 1 n n X dti-1425 161 2 engl engl PROPN dti-1425 161 3 j j PROPN dti-1425 161 4 med med PROPN dti-1425 161 5 . . PROPN dti-1425 162 1 2004;350(14):1422–1429 2004;350(14):1422–1429 NUM dti-1425 162 2 . . PROPN dti-1425 162 3 18 18 NUM dti-1425 162 4 . . PUNCT dti-1425 163 1 olsson olsson PROPN dti-1425 163 2 e e PROPN dti-1425 163 3 , , PUNCT dti-1425 163 4 friberg friberg PROPN dti-1425 163 5 ö ö PROPN dti-1425 163 6 , , PUNCT dti-1425 163 7 venizelos venizelo NOUN dti-1425 163 8 n n CCONJ dti-1425 163 9 , , PUNCT dti-1425 163 10 koskela koskela VERB dti-1425 163 11 a a DET dti-1425 163 12 , , PUNCT dti-1425 163 13 källman källman PROPN dti-1425 163 14 j j PROPN dti-1425 163 15 , , PUNCT dti-1425 163 16 söderquist söderquist PROPN dti-1425 163 17 b. b. PROPN dti-1425 163 18 coagulase coagulase PROPN dti-1425 163 19 - - PUNCT dti-1425 163 20 negative negative ADJ dti-1425 163 21 staphylococci staphylococci NOUN dti-1425 163 22 isolated isolate VERB dti-1425 163 23 from from ADP dti-1425 163 24 sternal sternal ADJ dti-1425 163 25 wound wound NOUN dti-1425 163 26 infections infection NOUN dti-1425 163 27 after after ADP dti-1425 163 28 cardiac cardiac ADJ dti-1425 163 29 surgery surgery NOUN dti-1425 163 30 : : PUNCT dti-1425 163 31 attachment attachment NOUN dti-1425 163 32 to to ADP dti-1425 163 33 and and CCONJ dti-1425 163 34 accumulation accumulation NOUN dti-1425 163 35 on on ADP dti-1425 163 36 sternal sternal ADJ dti-1425 163 37 fixation fixation NOUN dti-1425 163 38 stainless stainless ADJ dti-1425 163 39 steel steel NOUN dti-1425 163 40 wires wire NOUN dti-1425 163 41 . . PUNCT dti-1425 164 1 apmis apmis PROPN dti-1425 164 2 . . PUNCT dti-1425 165 1 2007;115(2):142–151 2007;115(2):142–151 NUM dti-1425 165 2 . . NOUN dti-1425 165 3 19 19 NUM dti-1425 165 4 . . PUNCT dti-1425 165 5 brunton brunton PROPN dti-1425 165 6 l l PROPN dti-1425 165 7 , , PUNCT dti-1425 165 8 chabner chabner PROPN dti-1425 165 9 b b PROPN dti-1425 165 10 , , PUNCT dti-1425 165 11 knollman knollman PROPN dti-1425 165 12 b. b. PROPN dti-1425 165 13 goodman goodman PROPN dti-1425 165 14 and and CCONJ dti-1425 165 15 gilman gilman PROPN dti-1425 165 16 ’s ’s PART dti-1425 165 17 the the DET dti-1425 165 18 pharmacological pharmacological ADJ dti-1425 165 19 basis basis NOUN dti-1425 165 20 of of ADP dti-1425 165 21 therapeutics therapeutic NOUN dti-1425 165 22 , , PUNCT dti-1425 165 23 ( ( PUNCT dti-1425 165 24 12th 12th NOUN dti-1425 165 25 ed ed NOUN dti-1425 165 26 . . PUNCT dti-1425 165 27 ) ) PUNCT dti-1425 165 28 . . PUNCT dti-1425 166 1 new new PROPN dti-1425 166 2 york york PROPN dti-1425 166 3 : : PUNCT dti-1425 166 4 mcgraw mcgraw PROPN dti-1425 166 5 - - PUNCT dti-1425 166 6 hill hill NOUN dti-1425 166 7 . . PUNCT dti-1425 167 1 2011 2011 NUM dti-1425 167 2 ; ; PUNCT dti-1425 167 3 2011 2011 NUM dti-1425 167 4 . . PUNCT dti-1425 168 1 20 20 NUM dti-1425 168 2 . . PUNCT dti-1425 169 1 pagkalis pagkalis PROPN dti-1425 169 2 s s PART dti-1425 169 3 , , PUNCT dti-1425 169 4 mantadakis mantadakis PROPN dti-1425 169 5 e e NOUN dti-1425 169 6 , , PUNCT dti-1425 169 7 mavros mavros PROPN dti-1425 169 8 mn mn PROPN dti-1425 169 9 , , PUNCT dti-1425 169 10 ammari ammari PROPN dti-1425 169 11 c c X dti-1425 169 12 , , PUNCT dti-1425 169 13 falagas falagas VERB dti-1425 169 14 me i PRON dti-1425 169 15 . . PUNCT dti-1425 170 1 pharmacological pharmacological ADJ dti-1425 170 2 considerations consideration NOUN dti-1425 170 3 for for ADP dti-1425 170 4 the the DET dti-1425 170 5 proper proper ADJ dti-1425 170 6 clinical clinical ADJ dti-1425 170 7 use use NOUN dti-1425 170 8 of of ADP dti-1425 170 9 aminoglycosides aminoglycoside NOUN dti-1425 170 10 . . PUNCT dti-1425 171 1 drugs drug NOUN dti-1425 171 2 . . PUNCT dti-1425 172 1 2011 2011 NUM dti-1425 172 2 ; ; PUNCT dti-1425 173 1 71(17):2277–2294 71(17):2277–2294 NUM dti-1425 173 2 . . PUNCT dti-1425 174 1 21 21 NUM dti-1425 174 2 . . PUNCT dti-1425 175 1 leyh leyh PROPN dti-1425 175 2 rg rg PROPN dti-1425 175 3 , , PUNCT dti-1425 175 4 bartels bartel NOUN dti-1425 175 5 c c PROPN dti-1425 175 6 , , PUNCT dti-1425 175 7 sievers sievers PROPN dti-1425 175 8 hh hh PROPN dti-1425 175 9 . . PROPN dti-1425 176 1 adjuvant adjuvant ADJ dti-1425 176 2 treatment treatment NOUN dti-1425 176 3 of of ADP dti-1425 176 4 deep deep ADJ dti-1425 176 5 sternal sternal ADJ dti-1425 176 6 wound wound NOUN dti-1425 176 7 infection infection NOUN dti-1425 176 8 with with ADP dti-1425 176 9 collagenous collagenous ADJ dti-1425 176 10 gentamycin gentamycin NOUN dti-1425 176 11 . . PUNCT dti-1425 177 1 ann ann PROPN dti-1425 177 2 thorac thorac PROPN dti-1425 177 3 surg surg NOUN dti-1425 177 4 . . PUNCT dti-1425 178 1 1999;68(5):1648–1651 1999;68(5):1648–1651 NUM dti-1425 178 2 . . PUNCT dti-1425 179 1 22 22 NUM dti-1425 179 2 . . PUNCT dti-1425 180 1 wahlig wahlig PROPN dti-1425 180 2 h. h. PROPN dti-1425 180 3 gentamicin gentamicin PROPN dti-1425 180 4 - - PUNCT dti-1425 180 5 pmma pmma PROPN dti-1425 180 6 beads bead NOUN dti-1425 180 7 : : PUNCT dti-1425 180 8 a a DET dti-1425 180 9 drug drug NOUN dti-1425 180 10 delivery delivery NOUN dti-1425 180 11 system system NOUN dti-1425 180 12 in in ADP dti-1425 180 13 the the DET dti-1425 180 14 treatment treatment NOUN dti-1425 180 15 of of ADP dti-1425 180 16 chronic chronic ADJ dti-1425 180 17 bone bone NOUN dti-1425 180 18 and and CCONJ dti-1425 180 19 soft soft ADJ dti-1425 180 20 tissue tissue NOUN dti-1425 180 21 infections infection NOUN dti-1425 180 22 . . PUNCT dti-1425 181 1 j j PROPN dti-1425 181 2 antimicrob antimicrob PROPN dti-1425 181 3 chemother chemother PROPN dti-1425 181 4 . . PUNCT dti-1425 182 1 1982 1982 NUM dti-1425 182 2 ; ; PUNCT dti-1425 183 1 10(5):463–465 10(5):463–465 PROPN dti-1425 183 2 . . PUNCT dti-1425 184 1 23 23 NUM dti-1425 184 2 . . PUNCT dti-1425 185 1 sendil sendil PROPN dti-1425 185 2 d d NOUN dti-1425 185 3 , , PUNCT dti-1425 185 4 gürsel gürsel PROPN dti-1425 185 5 i i PRON dti-1425 185 6 , , PUNCT dti-1425 185 7 wise wise ADJ dti-1425 185 8 dl dl PROPN dti-1425 185 9 , , PUNCT dti-1425 185 10 hasirci hasirci NOUN dti-1425 185 11 v. v. ADP dti-1425 185 12 antibiotic antibiotic ADJ dti-1425 185 13 release release NOUN dti-1425 185 14 from from ADP dti-1425 185 15 biodegradable biodegradable ADJ dti-1425 185 16 phbv phbv NOUN dti-1425 185 17 microparticles microparticle NOUN dti-1425 185 18 . . PUNCT dti-1425 186 1 j j PROPN dti-1425 186 2 control control PROPN dti-1425 186 3 release release PROPN dti-1425 186 4 . . PUNCT dti-1425 187 1 1999;59(2):207–217 1999;59(2):207–217 X dti-1425 187 2 . . PROPN dti-1425 187 3 24 24 NUM dti-1425 187 4 . . PUNCT dti-1425 188 1 türesin türesin PROPN dti-1425 188 2 f f PROPN dti-1425 188 3 , , PUNCT dti-1425 188 4 gürsel gürsel PROPN dti-1425 188 5 i i PRON dti-1425 188 6 , , PUNCT dti-1425 188 7 hasirci hasirci ADJ dti-1425 188 8 v. v. ADP dti-1425 188 9 biodegradable biodegradable ADJ dti-1425 188 10 polyhydroxyalkanoate polyhydroxyalkanoate NOUN dti-1425 188 11 implants implant NOUN dti-1425 188 12 for for ADP dti-1425 188 13 osteomyelitis osteomyelitis NOUN dti-1425 188 14 therapy therapy NOUN dti-1425 188 15 : : PUNCT dti-1425 188 16 in in ADP dti-1425 188 17 vitro vitro X dti-1425 188 18 antibiotic antibiotic ADJ dti-1425 188 19 release release NOUN dti-1425 188 20 . . PUNCT dti-1425 189 1 j j PROPN dti-1425 189 2 biomater biomater VERB dti-1425 189 3 sci sci PROPN dti-1425 189 4 polym polym PROPN dti-1425 189 5 ed ed NOUN dti-1425 189 6 . . PUNCT dti-1425 190 1 2001;12(2):195–207 2001;12(2):195–207 NOUN dti-1425 190 2 . . X dti-1425 191 1 25 25 NUM dti-1425 191 2 . . PUNCT dti-1425 191 3 brown brown PROPN dti-1425 191 4 jc jc PROPN dti-1425 191 5 , , PUNCT dti-1425 191 6 timpl timpl PROPN dti-1425 191 7 r. r. VERB dti-1425 191 8 the the DET dti-1425 191 9 collagen collagen NOUN dti-1425 191 10 superfamily superfamily NOUN dti-1425 191 11 . . PUNCT dti-1425 192 1 int int PROPN dti-1425 192 2 arch arch ADJ dti-1425 192 3 allergy allergy PROPN dti-1425 192 4 immunol immunol NOUN dti-1425 192 5 . . PUNCT dti-1425 193 1 1995 1995 NUM dti-1425 193 2 ; ; PUNCT dti-1425 194 1 107(4):484–490 107(4):484–490 NUM dti-1425 194 2 . . NOUN dti-1425 194 3 26 26 NUM dti-1425 194 4 . . PUNCT dti-1425 195 1 ramshaw ramshaw PROPN dti-1425 195 2 ja ja PROPN dti-1425 195 3 , , PUNCT dti-1425 195 4 werkmeister werkmeister PROPN dti-1425 195 5 ja ja PROPN dti-1425 195 6 , , PUNCT dti-1425 195 7 glattauer glattauer PROPN dti-1425 195 8 v. v. ADP dti-1425 195 9 collagen collagen NOUN dti-1425 195 10 - - PUNCT dti-1425 195 11 based base VERB dti-1425 195 12 biomaterials biomaterial NOUN dti-1425 195 13 . . PUNCT dti-1425 196 1 biotechnol biotechnol PROPN dti-1425 196 2 genet genet PROPN dti-1425 196 3 eng eng PROPN dti-1425 196 4 rev rev PROPN dti-1425 196 5 . . PUNCT dti-1425 196 6 1996;13:335–382 1996;13:335–382 NOUN dti-1425 196 7 . . PUNCT dti-1425 197 1 27 27 NUM dti-1425 197 2 . . PUNCT dti-1425 198 1 rao rao PROPN dti-1425 198 2 kp kp PROPN dti-1425 198 3 . . PUNCT dti-1425 199 1 recent recent ADJ dti-1425 199 2 developments development NOUN dti-1425 199 3 of of ADP dti-1425 199 4 collagen collagen NOUN dti-1425 199 5 - - PUNCT dti-1425 199 6 based base VERB dti-1425 199 7 materials material NOUN dti-1425 199 8 for for ADP dti-1425 199 9 medical medical ADJ dti-1425 199 10 applications application NOUN dti-1425 199 11 and and CCONJ dti-1425 199 12 drug drug NOUN dti-1425 199 13 delivery delivery NOUN dti-1425 199 14 systems system NOUN dti-1425 199 15 . . PUNCT dti-1425 200 1 j j PROPN dti-1425 200 2 biomater biomater VERB dti-1425 200 3 sci sci PROPN dti-1425 200 4 polym polym PROPN dti-1425 200 5 ed ed NOUN dti-1425 200 6 . . PUNCT dti-1425 201 1 1995;7(7):623–645 1995;7(7):623–645 NUM dti-1425 201 2 . . PUNCT dti-1425 201 3 28 28 NUM dti-1425 201 4 . . PUNCT dti-1425 202 1 schersten schersten PROPN dti-1425 202 2 h. h. PROPN dti-1425 202 3 modified modify VERB dti-1425 202 4 prophylaxis prophylaxis NOUN dti-1425 202 5 for for ADP dti-1425 202 6 preventing prevent VERB dti-1425 202 7 deep deep ADJ dti-1425 202 8 sternal sternal ADJ dti-1425 202 9 wound wound NOUN dti-1425 202 10 infection infection NOUN dti-1425 202 11 after after ADP dti-1425 202 12 cardiac cardiac ADJ dti-1425 202 13 surgery surgery NOUN dti-1425 202 14 . . PUNCT dti-1425 203 1 apmis apmis PROPN dti-1425 203 2 . . PUNCT dti-1425 204 1 2007;115(9):1025–1028 2007;115(9):1025–1028 ADJ dti-1425 204 2 . . NOUN dti-1425 204 3 29 29 NUM dti-1425 204 4 . . PUNCT dti-1425 205 1 kozioł kozioł PROPN dti-1425 205 2 m m PROPN dti-1425 205 3 , , PUNCT dti-1425 205 4 targońska targońska PROPN dti-1425 205 5 s s PROPN dti-1425 205 6 , , PUNCT dti-1425 205 7 stążka stążka PROPN dti-1425 205 8 j j PROPN dti-1425 205 9 , , PUNCT dti-1425 205 10 kozioł kozioł ADJ dti-1425 205 11 - - PUNCT dti-1425 205 12 montewka montewka NOUN dti-1425 205 13 m. m. NOUN dti-1425 205 14 gentamicin gentamicin NOUN dti-1425 205 15 - - PUNCT dti-1425 205 16 impregnated impregnate VERB dti-1425 205 17 collagen collagen NOUN dti-1425 205 18 sponge sponge NOUN dti-1425 205 19 for for ADP dti-1425 205 20 preventing prevent VERB dti-1425 205 21 sternal sternal ADJ dti-1425 205 22 wound wound NOUN dti-1425 205 23 infection infection NOUN dti-1425 205 24 after after ADP dti-1425 205 25 cardiac cardiac ADJ dti-1425 205 26 surgery surgery NOUN dti-1425 205 27 . . PUNCT dti-1425 206 1 kardiochir kardiochir PROPN dti-1425 206 2 torakochirurgia torakochirurgia PROPN dti-1425 206 3 pol pol PROPN dti-1425 206 4 . . PUNCT dti-1425 207 1 2014;11:21–25 2014;11:21–25 NUM dti-1425 207 2 . . X dti-1425 208 1 30 30 NUM dti-1425 208 2 . . X dti-1425 208 3 schimmer schimmer NOUN dti-1425 208 4 c c PROPN dti-1425 208 5 , , PUNCT dti-1425 208 6 özkur özkur PROPN dti-1425 208 7 m m PROPN dti-1425 208 8 , , PUNCT dti-1425 208 9 sinha sinha PROPN dti-1425 208 10 b b PROPN dti-1425 208 11 , , PUNCT dti-1425 208 12 et et PROPN dti-1425 208 13 al al PROPN dti-1425 208 14 . . PROPN dti-1425 208 15 gentamicin gentamicin PROPN dti-1425 208 16 - - PUNCT dti-1425 208 17 collagen collagen NOUN dti-1425 208 18 sponge sponge NOUN dti-1425 208 19 reduces reduce VERB dti-1425 208 20 sternal sternal ADJ dti-1425 208 21 wound wound NOUN dti-1425 208 22 complications complication NOUN dti-1425 208 23 after after ADP dti-1425 208 24 heart heart NOUN dti-1425 208 25 surgery surgery NOUN dti-1425 208 26 : : PUNCT dti-1425 208 27 a a DET dti-1425 208 28 controlled control VERB dti-1425 208 29 , , PUNCT dti-1425 208 30 prospectively prospectively ADV dti-1425 208 31 randomized randomize VERB dti-1425 208 32 , , PUNCT dti-1425 208 33 double double ADJ dti-1425 208 34 - - PUNCT dti-1425 208 35 blind blind ADJ dti-1425 208 36 study study NOUN dti-1425 208 37 . . PUNCT dti-1425 209 1 j j PROPN dti-1425 209 2 thorac thorac PROPN dti-1425 209 3 cardiovasc cardiovasc PROPN dti-1425 209 4 surg surg PROPN dti-1425 209 5 . . PUNCT dti-1425 210 1 2012;143(1):194–200 2012;143(1):194–200 NUM dti-1425 210 2 . . NOUN dti-1425 210 3 31 31 NUM dti-1425 210 4 . . X dti-1425 210 5 bennett bennett PROPN dti-1425 210 6 - - PUNCT dti-1425 210 7 guerrero guerrero PROPN dti-1425 210 8 e e PROPN dti-1425 210 9 , , PUNCT dti-1425 210 10 ferguson ferguson PROPN dti-1425 210 11 tb tb PROPN dti-1425 210 12 , , PUNCT dti-1425 210 13 lin lin PROPN dti-1425 210 14 m m PROPN dti-1425 210 15 , , PUNCT dti-1425 210 16 et et PROPN dti-1425 210 17 al al PROPN dti-1425 210 18 . . PROPN dti-1425 210 19 effect effect NOUN dti-1425 210 20 of of ADP dti-1425 210 21 an an DET dti-1425 210 22 implantable implantable ADJ dti-1425 210 23 gentamicin gentamicin NOUN dti-1425 210 24 - - PUNCT dti-1425 210 25 collagen collagen NOUN dti-1425 210 26 sponge sponge NOUN dti-1425 210 27 on on ADP dti-1425 210 28 sternal sternal ADJ dti-1425 210 29 wound wound NOUN dti-1425 210 30 infections infection NOUN dti-1425 210 31 following follow VERB dti-1425 210 32 cardiac cardiac ADJ dti-1425 210 33 surgery surgery NOUN dti-1425 210 34 : : PUNCT dti-1425 210 35 a a DET dti-1425 210 36 randomized randomized ADJ dti-1425 210 37 trial trial NOUN dti-1425 210 38 . . PUNCT dti-1425 211 1 jama jama PROPN dti-1425 211 2 . . PUNCT dti-1425 212 1 2010;304(7):755–762 2010;304(7):755–762 NUM dti-1425 212 2 . . NOUN dti-1425 212 3 32 32 NUM dti-1425 212 4 . . PUNCT dti-1425 213 1 lovering lovere VERB dti-1425 213 2 am am NOUN dti-1425 213 3 , , PUNCT dti-1425 213 4 sunderland sunderland PROPN dti-1425 213 5 j. j. PROPN dti-1425 213 6 impact impact PROPN dti-1425 213 7 of of ADP dti-1425 213 8 soaking soak VERB dti-1425 213 9 gentamicin gentamicin NOUN dti-1425 213 10 - - PUNCT dti-1425 213 11 containing contain VERB dti-1425 213 12 collagen collagen NOUN dti-1425 213 13 implants implant NOUN dti-1425 213 14 on on ADP dti-1425 213 15 potential potential ADJ dti-1425 213 16 antimicrobial antimicrobial ADJ dti-1425 213 17 efficacy efficacy NOUN dti-1425 213 18 . . PUNCT dti-1425 214 1 int int NOUN dti-1425 214 2 j j PROPN dti-1425 214 3 surg surg PROPN dti-1425 214 4 . . PUNCT dti-1425 215 1 2012;10(suppl 2012;10(suppl PROPN dti-1425 215 2 1 1 NUM dti-1425 215 3 ): ): PUNCT dti-1425 215 4 s2 s2 PROPN dti-1425 215 5 – – PUNCT dti-1425 215 6 s4 s4 NOUN dti-1425 215 7 . . PUNCT dti-1425 216 1 33 33 NUM dti-1425 216 2 . . PUNCT dti-1425 217 1 benedetto benedetto PROPN dti-1425 217 2 u u PROPN dti-1425 217 3 , , PUNCT dti-1425 217 4 raja raja PROPN dti-1425 217 5 sg sg PROPN dti-1425 217 6 . . PUNCT dti-1425 217 7 scoring score VERB dti-1425 217 8 system system NOUN dti-1425 217 9 to to PART dti-1425 217 10 guide guide VERB dti-1425 217 11 decision decision NOUN dti-1425 217 12 making making NOUN dti-1425 217 13 for for ADP dti-1425 217 14 the the DET dti-1425 217 15 use use NOUN dti-1425 217 16 of of ADP dti-1425 217 17 gentamicin gentamicin NOUN dti-1425 217 18 - - PUNCT dti-1425 217 19 impregnated impregnate VERB dti-1425 217 20 collagen collagen NOUN dti-1425 217 21 sponge sponge NOUN dti-1425 217 22 to to PART dti-1425 217 23 prevent prevent VERB dti-1425 217 24 deep deep ADJ dti-1425 217 25 sternal sternal ADJ dti-1425 217 26 wound wound NOUN dti-1425 217 27 infection infection NOUN dti-1425 217 28 . . PUNCT dti-1425 218 1 j j PROPN dti-1425 218 2 thorac thorac PROPN dti-1425 218 3 cardiovasc cardiovasc PROPN dti-1425 218 4 surg surg PROPN dti-1425 218 5 . . PUNCT dti-1425 219 1 2014;148(5):2390.e1–2396.e1 2014;148(5):2390.e1–2396.e1 X dti-1425 219 2 . . PUNCT dti-1425 220 1 34 34 NUM dti-1425 220 2 . . PUNCT dti-1425 221 1 toumpoulis toumpoulis PROPN dti-1425 221 2 ik ik PROPN dti-1425 221 3 , , PUNCT dti-1425 221 4 theakos theakos NOUN dti-1425 221 5 n n CCONJ dti-1425 221 6 , , PUNCT dti-1425 221 7 dunning dun VERB dti-1425 221 8 j. j. PROPN dti-1425 221 9 does do AUX dti-1425 221 10 bilateral bilateral ADJ dti-1425 221 11 internal internal ADJ dti-1425 221 12 thoracic thoracic NOUN dti-1425 221 13 artery artery NOUN dti-1425 221 14 harvest harvest NOUN dti-1425 221 15 increase increase VERB dti-1425 221 16 the the DET dti-1425 221 17 risk risk NOUN dti-1425 221 18 of of ADP dti-1425 221 19 mediastinitis mediastinitis NOUN dti-1425 221 20 ? ? PUNCT dti-1425 222 1 interact interact PROPN dti-1425 222 2 cardiovasc cardiovasc PROPN dti-1425 222 3 thorac thorac PROPN dti-1425 222 4 surg surg PROPN dti-1425 222 5 . . PUNCT dti-1425 223 1 2007 2007 NUM dti-1425 223 2 ; ; PUNCT dti-1425 223 3 6(6):787–791 6(6):787–791 NUM dti-1425 223 4 . . X dti-1425 224 1 35 35 NUM dti-1425 224 2 . . X dti-1425 224 3 birgand birgand PROPN dti-1425 224 4 g g PROPN dti-1425 224 5 , , PUNCT dti-1425 224 6 radu radu PROPN dti-1425 224 7 c c PROPN dti-1425 224 8 , , PUNCT dti-1425 224 9 alkhoder alkhoder PROPN dti-1425 224 10 s s PROPN dti-1425 224 11 , , PUNCT dti-1425 224 12 et et PROPN dti-1425 224 13 al al PROPN dti-1425 224 14 . . PROPN dti-1425 224 15 does do AUX dti-1425 224 16 a a DET dti-1425 224 17 gentamicin gentamicin NOUN dti-1425 224 18 - - PUNCT dti-1425 224 19 impregnated impregnate VERB dti-1425 224 20 collagen collagen NOUN dti-1425 224 21 sponge sponge NOUN dti-1425 224 22 reduce reduce VERB dti-1425 224 23 sternal sternal ADJ dti-1425 224 24 wound wound NOUN dti-1425 224 25 infections infection NOUN dti-1425 224 26 in in ADP dti-1425 224 27 high high ADJ dti-1425 224 28 - - PUNCT dti-1425 224 29 risk risk NOUN dti-1425 224 30 cardiac cardiac ADJ dti-1425 224 31 surgery surgery NOUN dti-1425 224 32 patients patient NOUN dti-1425 224 33 ? ? PUNCT dti-1425 225 1 interact interact PROPN dti-1425 225 2 cardiovasc cardiovasc PROPN dti-1425 225 3 thorac thorac PROPN dti-1425 225 4 surg surg NOUN dti-1425 225 5 . . PUNCT dti-1425 226 1 2013;16(2):134–141 2013;16(2):134–141 NUM dti-1425 226 2 . . X dti-1425 227 1 36 36 NUM dti-1425 227 2 . . PUNCT dti-1425 227 3 creanor creanor PROPN dti-1425 227 4 s s PROPN dti-1425 227 5 , , PUNCT dti-1425 227 6 barton barton PROPN dti-1425 227 7 a a PRON dti-1425 227 8 , , PUNCT dti-1425 227 9 marchbank marchbank ADJ dti-1425 227 10 a. a. NOUN dti-1425 227 11 effectiveness effectiveness NOUN dti-1425 227 12 of of ADP dti-1425 227 13 a a DET dti-1425 227 14 gentamicin gentamicin NOUN dti-1425 227 15 impregnated impregnated ADJ dti-1425 227 16 collagen collagen NOUN dti-1425 227 17 sponge sponge NOUN dti-1425 227 18 on on ADP dti-1425 227 19 reducing reduce VERB dti-1425 227 20 sternal sternal ADJ dti-1425 227 21 wound wound NOUN dti-1425 227 22 infections infection NOUN dti-1425 227 23 following follow VERB dti-1425 227 24 cardiac cardiac ADJ dti-1425 227 25 surgery surgery NOUN dti-1425 227 26 : : PUNCT dti-1425 227 27 a a DET dti-1425 227 28 meta meta ADJ dti-1425 227 29 - - PUNCT dti-1425 227 30 analysis analysis NOUN dti-1425 227 31 of of ADP dti-1425 227 32 randomised randomised ADJ dti-1425 227 33 controlled control VERB dti-1425 227 34 trials trial NOUN dti-1425 227 35 . . PUNCT dti-1425 228 1 ann ann PROPN dti-1425 228 2 r r PROPN dti-1425 228 3 coll coll PROPN dti-1425 228 4 surg surg PROPN dti-1425 228 5 engl engl PROPN dti-1425 228 6 . . PUNCT dti-1425 229 1 2012;94(4):227–231 2012;94(4):227–231 ADJ dti-1425 229 2 . . PUNCT dti-1425 229 3 figure figure NOUN dti-1425 229 4 2 2 NUM dti-1425 229 5 . . PUNCT dti-1425 229 6 baseline baseline NOUN dti-1425 229 7 score score NOUN dti-1425 229 8 points point NOUN dti-1425 229 9 according accord VERB dti-1425 229 10 to to ADP dti-1425 229 11 bmi bmi PROPN dti-1425 229 12 ( ( PUNCT dti-1425 229 13 data datum NOUN dti-1425 229 14 from from ADP dti-1425 229 15 ref ref NOUN dti-1425 229 16 . . PUNCT dti-1425 230 1 33 33 NUM dti-1425 230 2 ) ) PUNCT dti-1425 230 3 . . PUNCT dti-1425 231 1 abbreviation abbreviation NOUN dti-1425 231 2 : : PUNCT dti-1425 231 3 bmi bmi PROPN dti-1425 231 4 , , PUNCT dti-1425 231 5 body body NOUN dti-1425 231 6 mass mass PROPN dti-1425 231 7 index index NOUN dti-1425 231 8 . . PUNCT dti-1425 232 1 http://www.la-press.com http://www.la-press.com X dti-1425 232 2 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN