id sid tid token lemma pos dti-1426 1 1 1drug 1drug NUM dti-1426 1 2 target target NOUN dti-1426 1 3 insights insight NOUN dti-1426 1 4 2016:10(s1 2016:10(s1 NUM dti-1426 1 5 ) ) PUNCT dti-1426 1 6 preliminary preliminary ADJ dti-1426 1 7 in in ADP dti-1426 1 8 vivo vivo ADJ dti-1426 1 9 evaluation evaluation NOUN dti-1426 1 10 of of ADP dti-1426 1 11 a a DET dti-1426 1 12 hybrid hybrid ADJ dti-1426 1 13 armored armored ADJ dti-1426 1 14 vascular vascular ADJ dti-1426 1 15 graft graft NOUN dti-1426 1 16 combining combine VERB dti-1426 1 17 electrospinning electrospinne VERB dti-1426 1 18 and and CCONJ dti-1426 1 19 additive additive NOUN dti-1426 1 20 manufacturing manufacturing NOUN dti-1426 1 21 techniques technique NOUN dti-1426 1 22 supplementary supplementary ADJ dti-1426 1 23 issue issue NOUN dti-1426 1 24 : : PUNCT dti-1426 1 25 current current ADJ dti-1426 1 26 developments development NOUN dti-1426 1 27 in in ADP dti-1426 1 28 drug drug NOUN dti-1426 1 29 eluting eluting NOUN dti-1426 1 30 devices device NOUN dti-1426 1 31 cristiano cristiano PROPN dti-1426 1 32 spadaccio1 spadaccio1 PROPN dti-1426 1 33 , , PUNCT dti-1426 1 34 * * PROPN dti-1426 1 35 , , PUNCT dti-1426 1 36 francesco francesco PROPN dti-1426 1 37 nappi2 nappi2 PROPN dti-1426 1 38 , , PUNCT dti-1426 1 39 * * PUNCT dti-1426 1 40 , , PUNCT dti-1426 1 41 federico federico PROPN dti-1426 1 42 de de PROPN dti-1426 1 43 marco3 marco3 PROPN dti-1426 1 44 , , PUNCT dti-1426 1 45 pietro pietro PROPN dti-1426 1 46 sedati4 sedati4 PROPN dti-1426 1 47 , , PUNCT dti-1426 1 48 fraser fraser PROPN dti-1426 1 49 w.h w.h PROPN dti-1426 1 50 . . PROPN dti-1426 1 51 sutherland1 sutherland1 PROPN dti-1426 1 52 , , PUNCT dti-1426 1 53 massimo massimo PROPN dti-1426 1 54 chello5 chello5 PROPN dti-1426 1 55 , , PUNCT dti-1426 1 56 marcella marcella PROPN dti-1426 1 57 trombetta6 trombetta6 PROPN dti-1426 1 58 and and CCONJ dti-1426 1 59 alberto alberto PROPN dti-1426 1 60 rainer6 rainer6 PROPN dti-1426 1 61 1department 1department NUM dti-1426 1 62 of of ADP dti-1426 1 63 cardiothoracic cardiothoracic NOUN dti-1426 1 64 surgery surgery NOUN dti-1426 1 65 , , PUNCT dti-1426 1 66 golden golden ADJ dti-1426 1 67 jubilee jubilee PROPN dti-1426 1 68 national national PROPN dti-1426 1 69 hospital hospital PROPN dti-1426 1 70 , , PUNCT dti-1426 1 71 clydebank clydebank PROPN dti-1426 1 72 , , PUNCT dti-1426 1 73 dunbartonshire dunbartonshire NOUN dti-1426 1 74 , , PUNCT dti-1426 1 75 uk uk PROPN dti-1426 1 76 . . PROPN dti-1426 1 77 2cardiac 2cardiac NUM dti-1426 1 78 surgery surgery NOUN dti-1426 1 79 , , PUNCT dti-1426 1 80 centre centre NOUN dti-1426 1 81 cardiologique cardiologique NOUN dti-1426 1 82 du du PROPN dti-1426 1 83 nord nord PROPN dti-1426 1 84 de de PROPN dti-1426 1 85 saint saint PROPN dti-1426 1 86 - - PUNCT dti-1426 1 87 denis denis PROPN dti-1426 1 88 , , PUNCT dti-1426 1 89 paris paris PROPN dti-1426 1 90 , , PUNCT dti-1426 1 91 france france PROPN dti-1426 1 92 . . PUNCT dti-1426 2 1 3laboratory 3laboratory NUM dti-1426 2 2 of of ADP dti-1426 2 3 virology virology NOUN dti-1426 2 4 , , PUNCT dti-1426 2 5 the the DET dti-1426 2 6 regina regina PROPN dti-1426 2 7 elena elena PROPN dti-1426 2 8 national national PROPN dti-1426 2 9 cancer cancer PROPN dti-1426 2 10 institute institute PROPN dti-1426 2 11 , , PUNCT dti-1426 2 12 rome rome PROPN dti-1426 2 13 , , PUNCT dti-1426 2 14 italy italy PROPN dti-1426 2 15 . . PUNCT dti-1426 3 1 4unit 4unit NUM dti-1426 3 2 of of ADP dti-1426 3 3 imaging imaging NOUN dti-1426 3 4 and and CCONJ dti-1426 3 5 diagnostics diagnostic NOUN dti-1426 3 6 , , PUNCT dti-1426 3 7 università università PROPN dti-1426 3 8 campus campus PROPN dti-1426 3 9 bio bio PROPN dti-1426 3 10 - - ADJ dti-1426 3 11 medico medico ADJ dti-1426 3 12 di di X dti-1426 3 13 roma roma PROPN dti-1426 3 14 , , PUNCT dti-1426 3 15 rome rome PROPN dti-1426 3 16 , , PUNCT dti-1426 3 17 italy italy PROPN dti-1426 3 18 . . PUNCT dti-1426 4 1 5unit 5unit NUM dti-1426 4 2 of of ADP dti-1426 4 3 cardiac cardiac ADJ dti-1426 4 4 surgery surgery NOUN dti-1426 4 5 , , PUNCT dti-1426 4 6 università università PROPN dti-1426 4 7 campus campus PROPN dti-1426 4 8 bio bio PROPN dti-1426 4 9 - - ADJ dti-1426 4 10 medico medico ADJ dti-1426 4 11 di di X dti-1426 4 12 roma roma PROPN dti-1426 4 13 , , PUNCT dti-1426 4 14 rome rome PROPN dti-1426 4 15 , , PUNCT dti-1426 4 16 italy italy PROPN dti-1426 4 17 . . PUNCT dti-1426 5 1 6tissue 6tissue NUM dti-1426 5 2 engineering engineer VERB dti-1426 5 3 laboratory laboratory NOUN dti-1426 5 4 , , PUNCT dti-1426 5 5 università università PROPN dti-1426 5 6 campus campus PROPN dti-1426 5 7 bio bio PROPN dti-1426 5 8 - - ADJ dti-1426 5 9 medico medico ADJ dti-1426 5 10 di di X dti-1426 5 11 roma roma PROPN dti-1426 5 12 , , PUNCT dti-1426 5 13 rome rome PROPN dti-1426 5 14 , , PUNCT dti-1426 5 15 italy italy PROPN dti-1426 5 16 . . PUNCT dti-1426 6 1 * * PUNCT dti-1426 6 2 these these DET dti-1426 6 3 authors author NOUN dti-1426 6 4 contributed contribute VERB dti-1426 6 5 equally equally ADV dti-1426 6 6 to to ADP dti-1426 6 7 this this DET dti-1426 6 8 work work NOUN dti-1426 6 9 . . PUNCT dti-1426 7 1 abstr abstr PROPN dti-1426 7 2 act act PROPN dti-1426 7 3 : : PUNCT dti-1426 7 4 in in ADP dti-1426 7 5 this this DET dti-1426 7 6 study study NOUN dti-1426 7 7 , , PUNCT dti-1426 7 8 we we PRON dti-1426 7 9 tested test VERB dti-1426 7 10 in in ADP dti-1426 7 11 vivo vivo ADJ dti-1426 7 12 effectiveness effectiveness NOUN dti-1426 7 13 of of ADP dti-1426 7 14 a a DET dti-1426 7 15 previously previously ADV dti-1426 7 16 developed develop VERB dti-1426 7 17 poly poly ADJ dti-1426 7 18 - - PUNCT dti-1426 7 19 l l NOUN dti-1426 7 20 - - PUNCT dti-1426 7 21 lactide lactide ADJ dti-1426 7 22 / / SYM dti-1426 7 23 poly poly ADJ dti-1426 7 24 - - PUNCT dti-1426 7 25 e e NOUN dti-1426 7 26 - - NOUN dti-1426 7 27 caprolactone caprolactone ADJ dti-1426 7 28 armored armored ADJ dti-1426 7 29 vascular vascular ADJ dti-1426 7 30 graft graft NOUN dti-1426 7 31 releasing release VERB dti-1426 7 32 heparin heparin NOUN dti-1426 7 33 . . PUNCT dti-1426 8 1 this this DET dti-1426 8 2 bioprosthesis bioprosthesis NOUN dti-1426 8 3 was be AUX dti-1426 8 4 designed design VERB dti-1426 8 5 in in ADP dti-1426 8 6 order order NOUN dti-1426 8 7 to to PART dti-1426 8 8 overcome overcome VERB dti-1426 8 9 the the DET dti-1426 8 10 main main ADJ dti-1426 8 11 drawbacks drawback NOUN dti-1426 8 12 of of ADP dti-1426 8 13 tissue tissue NOUN dti-1426 8 14 - - PUNCT dti-1426 8 15 engineered engineer VERB dti-1426 8 16 vascular vascular ADJ dti-1426 8 17 grafts graft NOUN dti-1426 8 18 , , PUNCT dti-1426 8 19 mainly mainly ADV dti-1426 8 20 concerning concern VERB dti-1426 8 21 poor poor ADJ dti-1426 8 22 mechanical mechanical ADJ dti-1426 8 23 properties property NOUN dti-1426 8 24 , , PUNCT dti-1426 8 25 thrombogenicity thrombogenicity NOUN dti-1426 8 26 , , PUNCT dti-1426 8 27 and and CCONJ dti-1426 8 28 endothelialization endothelialization NOUN dti-1426 8 29 . . PUNCT dti-1426 9 1 the the DET dti-1426 9 2 bioprosthesis bioprosthesis NOUN dti-1426 9 3 was be AUX dti-1426 9 4 successfully successfully ADV dti-1426 9 5 implanted implant VERB dti-1426 9 6 in in ADP dti-1426 9 7 an an DET dti-1426 9 8 aortic aortic ADJ dti-1426 9 9 vascular vascular ADJ dti-1426 9 10 reconstruction reconstruction NOUN dti-1426 9 11 model model NOUN dti-1426 9 12 in in ADP dti-1426 9 13 rabbits rabbit NOUN dti-1426 9 14 . . PUNCT dti-1426 10 1 all all DET dti-1426 10 2 grafts graft NOUN dti-1426 10 3 implanted implant VERB dti-1426 10 4 were be AUX dti-1426 10 5 patent patent NOUN dti-1426 10 6 at at ADP dti-1426 10 7 four four NUM dti-1426 10 8 weeks week NOUN dti-1426 10 9 postoperatively postoperatively ADV dti-1426 10 10 and and CCONJ dti-1426 10 11 have have AUX dti-1426 10 12 been be AUX dti-1426 10 13 adequately adequately ADV dti-1426 10 14 populated populate VERB dti-1426 10 15 by by ADP dti-1426 10 16 endogenous endogenous ADJ dti-1426 10 17 cells cell NOUN dti-1426 10 18 without without ADP dti-1426 10 19 signs sign NOUN dti-1426 10 20 of of ADP dti-1426 10 21 thrombosis thrombosis NOUN dti-1426 10 22 or or CCONJ dti-1426 10 23 structural structural ADJ dti-1426 10 24 failure failure NOUN dti-1426 10 25 and and CCONJ dti-1426 10 26 with with ADP dti-1426 10 27 no no DET dti-1426 10 28 need need NOUN dti-1426 10 29 of of ADP dti-1426 10 30 antiplatelet antiplatelet NOUN dti-1426 10 31 therapy therapy NOUN dti-1426 10 32 . . PUNCT dti-1426 11 1 the the DET dti-1426 11 2 results result NOUN dti-1426 11 3 of of ADP dti-1426 11 4 this this DET dti-1426 11 5 preliminary preliminary ADJ dti-1426 11 6 study study NOUN dti-1426 11 7 might might AUX dti-1426 11 8 warrant warrant VERB dti-1426 11 9 for for ADP dti-1426 11 10 further far ADV dti-1426 11 11 larger large ADJ dti-1426 11 12 controlled control VERB dti-1426 11 13 in in ADP dti-1426 11 14 vivo vivo ADJ dti-1426 11 15 studies study NOUN dti-1426 11 16 to to PART dti-1426 11 17 further far ADV dti-1426 11 18 confirm confirm VERB dti-1426 11 19 these these DET dti-1426 11 20 findings finding NOUN dti-1426 11 21 . . PUNCT dti-1426 12 1 key key ADJ dti-1426 12 2 words word NOUN dti-1426 12 3 : : PUNCT dti-1426 12 4 vascular vascular ADJ dti-1426 12 5 graft graft NOUN dti-1426 12 6 , , PUNCT dti-1426 12 7 computer computer NOUN dti-1426 12 8 - - PUNCT dti-1426 12 9 aided aid VERB dti-1426 12 10 tissue tissue NOUN dti-1426 12 11 engineering engineering NOUN dti-1426 12 12 , , PUNCT dti-1426 12 13 electrospinning electrospinne VERB dti-1426 12 14 , , PUNCT dti-1426 12 15 additive additive ADJ dti-1426 12 16 manufacturing manufacturing NOUN dti-1426 12 17 , , PUNCT dti-1426 12 18 heparin heparin NOUN dti-1426 12 19 , , PUNCT dti-1426 12 20 drug drug NOUN dti-1426 12 21 release release NOUN dti-1426 12 22 supplement supplement NOUN dti-1426 12 23 : : PUNCT dti-1426 12 24 current current ADJ dti-1426 12 25 developments development NOUN dti-1426 12 26 in in ADP dti-1426 12 27 drug drug NOUN dti-1426 12 28 eluting eluting NOUN dti-1426 12 29 devices device NOUN dti-1426 12 30 citation citation NOUN dti-1426 12 31 : : PUNCT dti-1426 12 32 spadaccio spadaccio PROPN dti-1426 12 33 et et PROPN dti-1426 12 34 al al PROPN dti-1426 12 35 . . PROPN dti-1426 12 36 preliminary preliminary ADJ dti-1426 12 37 in in ADP dti-1426 12 38 vivo vivo ADJ dti-1426 12 39 evaluation evaluation NOUN dti-1426 12 40 of of ADP dti-1426 12 41 a a DET dti-1426 12 42 hybrid hybrid ADJ dti-1426 12 43 armored armored ADJ dti-1426 12 44 vascular vascular ADJ dti-1426 12 45 graft graft NOUN dti-1426 12 46 combining combine VERB dti-1426 12 47 electrospinning electrospinne VERB dti-1426 12 48 and and CCONJ dti-1426 12 49 additive additive ADJ dti-1426 12 50 manufacturing manufacturing NOUN dti-1426 12 51 techniques technique NOUN dti-1426 12 52 . . PUNCT dti-1426 13 1 drug drug NOUN dti-1426 13 2 target target NOUN dti-1426 13 3 insights insight NOUN dti-1426 13 4 2016:10(s1 2016:10(s1 NUM dti-1426 13 5 ) ) PUNCT dti-1426 13 6 1–7 1–7 NUM dti-1426 13 7 doi:10.4137 doi:10.4137 NOUN dti-1426 13 8 / / SYM dti-1426 13 9 dti.s35202 dti.s35202 PROPN dti-1426 13 10 . . PUNCT dti-1426 14 1 type type NOUN dti-1426 14 2 : : PUNCT dti-1426 14 3 original original ADJ dti-1426 14 4 research research NOUN dti-1426 14 5 received receive VERB dti-1426 14 6 : : PUNCT dti-1426 14 7 september september PROPN dti-1426 14 8 25 25 NUM dti-1426 14 9 , , PUNCT dti-1426 14 10 2015 2015 NUM dti-1426 14 11 . . PUNCT dti-1426 15 1 resubmitted resubmitte VERB dti-1426 15 2 : : PUNCT dti-1426 15 3 november november PROPN dti-1426 15 4 12 12 NUM dti-1426 15 5 , , PUNCT dti-1426 15 6 2015 2015 NUM dti-1426 15 7 . . PUNCT dti-1426 16 1 accepted accept VERB dti-1426 16 2 for for ADP dti-1426 16 3 publication publication NOUN dti-1426 16 4 : : PUNCT dti-1426 16 5 november november PROPN dti-1426 16 6 16 16 NUM dti-1426 16 7 , , PUNCT dti-1426 16 8 2015 2015 NUM dti-1426 16 9 . . PUNCT dti-1426 17 1 academic academic ADJ dti-1426 17 2 editor editor NOUN dti-1426 17 3 : : PUNCT dti-1426 17 4 anuj anuj PROPN dti-1426 17 5 chauhan chauhan PROPN dti-1426 17 6 , , PUNCT dti-1426 17 7 editor editor NOUN dti-1426 17 8 in in ADP dti-1426 17 9 chief chief ADJ dti-1426 17 10 peer peer NOUN dti-1426 17 11 review review NOUN dti-1426 17 12 : : PUNCT dti-1426 17 13 three three NUM dti-1426 17 14 peer peer NOUN dti-1426 17 15 reviewers reviewer NOUN dti-1426 17 16 contributed contribute VERB dti-1426 17 17 to to ADP dti-1426 17 18 the the DET dti-1426 17 19 peer peer NOUN dti-1426 17 20 review review NOUN dti-1426 17 21 report report NOUN dti-1426 17 22 . . PUNCT dti-1426 18 1 reviewers reviewer NOUN dti-1426 18 2 ’ ' PUNCT dti-1426 18 3 reports report NOUN dti-1426 18 4 totaled total VERB dti-1426 18 5 507 507 NUM dti-1426 18 6 words word NOUN dti-1426 18 7 , , PUNCT dti-1426 18 8 excluding exclude VERB dti-1426 18 9 any any DET dti-1426 18 10 confidential confidential ADJ dti-1426 18 11 comments comment NOUN dti-1426 18 12 to to ADP dti-1426 18 13 the the DET dti-1426 18 14 academic academic ADJ dti-1426 18 15 editor editor NOUN dti-1426 18 16 . . PUNCT dti-1426 19 1 funding funding NOUN dti-1426 19 2 : : PUNCT dti-1426 19 3 authors author NOUN dti-1426 19 4 disclose disclose VERB dti-1426 19 5 no no DET dti-1426 19 6 external external ADJ dti-1426 19 7 funding funding NOUN dti-1426 19 8 sources source NOUN dti-1426 19 9 . . PUNCT dti-1426 20 1 competing compete VERB dti-1426 20 2 interests interest NOUN dti-1426 20 3 : : PUNCT dti-1426 20 4 authors author NOUN dti-1426 20 5 disclose disclose VERB dti-1426 20 6 no no DET dti-1426 20 7 potential potential ADJ dti-1426 20 8 conflicts conflict NOUN dti-1426 20 9 of of ADP dti-1426 20 10 interest interest NOUN dti-1426 20 11 . . PUNCT dti-1426 21 1 copyright copyright NOUN dti-1426 21 2 : : PUNCT dti-1426 21 3 © © PROPN dti-1426 21 4 the the DET dti-1426 21 5 authors author NOUN dti-1426 21 6 , , PUNCT dti-1426 21 7 publisher publisher NOUN dti-1426 21 8 and and CCONJ dti-1426 21 9 licensee licensee NOUN dti-1426 21 10 libertas liberta NOUN dti-1426 21 11 academica academica PROPN dti-1426 21 12 limited limit VERB dti-1426 21 13 . . PUNCT dti-1426 22 1 this this PRON dti-1426 22 2 is be AUX dti-1426 22 3 an an DET dti-1426 22 4 open open ADJ dti-1426 22 5 - - PUNCT dti-1426 22 6 access access NOUN dti-1426 22 7 article article NOUN dti-1426 22 8 distributed distribute VERB dti-1426 22 9 under under ADP dti-1426 22 10 the the DET dti-1426 22 11 terms term NOUN dti-1426 22 12 of of ADP dti-1426 22 13 the the DET dti-1426 22 14 creative creative ADJ dti-1426 22 15 commons common NOUN dti-1426 22 16 cc cc NOUN dti-1426 22 17 - - PUNCT dti-1426 22 18 by by ADP dti-1426 22 19 - - PUNCT dti-1426 22 20 nc nc PROPN dti-1426 22 21 3.0 3.0 NUM dti-1426 22 22 license license NOUN dti-1426 22 23 . . PUNCT dti-1426 23 1 correspondence correspondence NOUN dti-1426 23 2 : : PUNCT dti-1426 24 1 cristiano.spadaccio@gjnh.scot.nhs.uk cristiano.spadaccio@gjnh.scot.nhs.uk PRON dti-1426 24 2 paper paper NOUN dti-1426 24 3 subject subject NOUN dti-1426 24 4 to to ADP dti-1426 24 5 independent independent ADJ dti-1426 24 6 expert expert ADJ dti-1426 24 7 blind blind ADJ dti-1426 24 8 peer peer NOUN dti-1426 24 9 review review NOUN dti-1426 24 10 . . PUNCT dti-1426 25 1 all all DET dti-1426 25 2 editorial editorial ADJ dti-1426 25 3 decisions decision NOUN dti-1426 25 4 made make VERB dti-1426 25 5 by by ADP dti-1426 25 6 independent independent ADJ dti-1426 25 7 academic academic ADJ dti-1426 25 8 editor editor NOUN dti-1426 25 9 . . PUNCT dti-1426 26 1 upon upon SCONJ dti-1426 26 2 submission submission NOUN dti-1426 26 3 manuscript manuscript NOUN dti-1426 26 4 was be AUX dti-1426 26 5 subject subject ADJ dti-1426 26 6 to to ADP dti-1426 26 7 antiplagiarism antiplagiarism NOUN dti-1426 26 8 scanning scanning NOUN dti-1426 26 9 . . PUNCT dti-1426 27 1 prior prior ADV dti-1426 27 2 to to ADP dti-1426 27 3 publication publication NOUN dti-1426 27 4 all all DET dti-1426 27 5 authors author NOUN dti-1426 27 6 have have AUX dti-1426 27 7 given give VERB dti-1426 27 8 signed sign VERB dti-1426 27 9 confirmation confirmation NOUN dti-1426 27 10 of of ADP dti-1426 27 11 agreement agreement NOUN dti-1426 27 12 to to ADP dti-1426 27 13 article article NOUN dti-1426 27 14 publication publication NOUN dti-1426 27 15 and and CCONJ dti-1426 27 16 compliance compliance NOUN dti-1426 27 17 with with ADP dti-1426 27 18 all all DET dti-1426 27 19 applicable applicable ADJ dti-1426 27 20 ethical ethical ADJ dti-1426 27 21 and and CCONJ dti-1426 27 22 legal legal ADJ dti-1426 27 23 requirements requirement NOUN dti-1426 27 24 , , PUNCT dti-1426 27 25 including include VERB dti-1426 27 26 the the DET dti-1426 27 27 accuracy accuracy NOUN dti-1426 27 28 of of ADP dti-1426 27 29 author author NOUN dti-1426 27 30 and and CCONJ dti-1426 27 31 contributor contributor NOUN dti-1426 27 32 information information NOUN dti-1426 27 33 , , PUNCT dti-1426 27 34 disclosure disclosure NOUN dti-1426 27 35 of of ADP dti-1426 27 36 competing compete VERB dti-1426 27 37 interests interest NOUN dti-1426 27 38 and and CCONJ dti-1426 27 39 funding funding NOUN dti-1426 27 40 sources source NOUN dti-1426 27 41 , , PUNCT dti-1426 27 42 compliance compliance NOUN dti-1426 27 43 with with ADP dti-1426 27 44 ethical ethical ADJ dti-1426 27 45 requirements requirement NOUN dti-1426 27 46 relating relate VERB dti-1426 27 47 to to ADP dti-1426 27 48 human human ADJ dti-1426 27 49 and and CCONJ dti-1426 27 50 animal animal NOUN dti-1426 27 51 study study NOUN dti-1426 27 52 participants participant NOUN dti-1426 27 53 , , PUNCT dti-1426 27 54 and and CCONJ dti-1426 27 55 compliance compliance NOUN dti-1426 27 56 with with ADP dti-1426 27 57 any any DET dti-1426 27 58 copyright copyright NOUN dti-1426 27 59 requirements requirement NOUN dti-1426 27 60 of of ADP dti-1426 27 61 third third ADJ dti-1426 27 62 parties party NOUN dti-1426 27 63 . . PUNCT dti-1426 28 1 this this DET dti-1426 28 2 journal journal NOUN dti-1426 28 3 is be AUX dti-1426 28 4 a a DET dti-1426 28 5 member member NOUN dti-1426 28 6 of of ADP dti-1426 28 7 the the DET dti-1426 28 8 committee committee NOUN dti-1426 28 9 on on ADP dti-1426 28 10 publication publication NOUN dti-1426 28 11 ethics ethic NOUN dti-1426 28 12 ( ( PUNCT dti-1426 28 13 cope cope PROPN dti-1426 28 14 ) ) PUNCT dti-1426 28 15 . . PUNCT dti-1426 29 1 published publish VERB dti-1426 29 2 by by ADP dti-1426 29 3 libertas liberta NOUN dti-1426 29 4 academica academica PROPN dti-1426 29 5 . . PUNCT dti-1426 30 1 learn learn VERB dti-1426 30 2 more more ADJ dti-1426 30 3 about about ADP dti-1426 30 4 this this DET dti-1426 30 5 journal journal NOUN dti-1426 30 6 . . PUNCT dti-1426 31 1 introduction introduction NOUN dti-1426 31 2 cardiovascular cardiovascular ADJ dti-1426 31 3 diseases disease NOUN dti-1426 31 4 are be AUX dti-1426 31 5 nowadays nowadays ADV dti-1426 31 6 emerging emerge VERB dti-1426 31 7 as as ADP dti-1426 31 8 an an DET dti-1426 31 9 overwhelming overwhelming ADJ dti-1426 31 10 clinical clinical ADJ dti-1426 31 11 reality reality NOUN dti-1426 31 12 leading lead VERB dti-1426 31 13 to to ADP dti-1426 31 14 high high ADJ dti-1426 31 15 morbidity morbidity NOUN dti-1426 31 16 and and CCONJ dti-1426 31 17 requiring require VERB dti-1426 31 18 several several ADJ dti-1426 31 19 surgical surgical ADJ dti-1426 31 20 procedures procedure NOUN dti-1426 31 21 such such ADJ dti-1426 31 22 as as ADP dti-1426 31 23 arterial arterial ADJ dti-1426 31 24 bypass bypass NOUN dti-1426 31 25 and and CCONJ dti-1426 31 26 vascular vascular ADJ dti-1426 31 27 replacing replacing NOUN dti-1426 31 28 . . PUNCT dti-1426 32 1 currently currently ADV dti-1426 32 2 used use VERB dti-1426 32 3 prosthetic prosthetic ADJ dti-1426 32 4 vascular vascular ADJ dti-1426 32 5 graft graft NOUN dti-1426 32 6 materials material NOUN dti-1426 32 7 such such ADJ dti-1426 32 8 as as ADP dti-1426 32 9 polyethylene polyethylene NOUN dti-1426 32 10 terephthalate terephthalate NOUN dti-1426 32 11 and and CCONJ dti-1426 32 12 polytetrafluoroethylene polytetrafluoroethylene NOUN dti-1426 32 13 ( ( PUNCT dti-1426 32 14 ptfe ptfe NOUN dti-1426 32 15 ) ) PUNCT dti-1426 32 16 are be AUX dti-1426 32 17 often often ADV dti-1426 32 18 inadequate inadequate ADJ dti-1426 32 19 because because SCONJ dti-1426 32 20 of of ADP dti-1426 32 21 limitations limitation NOUN dti-1426 32 22 regarding regard VERB dti-1426 32 23 thrombogenicity thrombogenicity NOUN dti-1426 32 24 , , PUNCT dti-1426 32 25 graft graft NOUN dti-1426 32 26 failure failure NOUN dti-1426 32 27 , , PUNCT dti-1426 32 28 and and CCONJ dti-1426 32 29 infection infection NOUN dti-1426 32 30 , , PUNCT dti-1426 32 31 especially especially ADV dti-1426 32 32 when when SCONJ dti-1426 32 33 used use VERB dti-1426 32 34 for for ADP dti-1426 32 35 small small ADJ dti-1426 32 36 - - PUNCT dti-1426 32 37 caliber caliber NOUN dti-1426 32 38 vessel vessel NOUN dti-1426 32 39 bypass bypass NOUN dti-1426 32 40 grafting grafting NOUN dti-1426 32 41 . . PUNCT dti-1426 33 1 on on ADP dti-1426 33 2 the the DET dti-1426 33 3 other other ADJ dti-1426 33 4 side side NOUN dti-1426 33 5 , , PUNCT dti-1426 33 6 the the DET dti-1426 33 7 use use NOUN dti-1426 33 8 of of ADP dti-1426 33 9 autografts autograft NOUN dti-1426 33 10 , , PUNCT dti-1426 33 11 such such ADJ dti-1426 33 12 as as ADP dti-1426 33 13 internal internal ADJ dti-1426 33 14 thoracic thoracic NOUN dti-1426 33 15 artery artery NOUN dti-1426 33 16 or or CCONJ dti-1426 33 17 safenous safenous ADJ dti-1426 33 18 vein vein NOUN dti-1426 33 19 , , PUNCT dti-1426 33 20 is be AUX dti-1426 33 21 harnessed harness VERB dti-1426 33 22 by by ADP dti-1426 33 23 problems problem NOUN dti-1426 33 24 of of ADP dti-1426 33 25 poor poor ADJ dti-1426 33 26 quality quality NOUN dti-1426 33 27 , , PUNCT dti-1426 33 28 especially especially ADV dti-1426 33 29 in in ADP dti-1426 33 30 the the DET dti-1426 33 31 elderly elderly ADJ dti-1426 33 32 , , PUNCT dti-1426 33 33 and and CCONJ dti-1426 33 34 inadequate inadequate ADJ dti-1426 33 35 size size NOUN dti-1426 33 36 or or CCONJ dti-1426 33 37 length length NOUN dti-1426 33 38 of of ADP dti-1426 33 39 the the DET dti-1426 33 40 vascular vascular ADJ dti-1426 33 41 conduit conduit NOUN dti-1426 33 42 itself itself PRON dti-1426 33 43 . . PUNCT dti-1426 34 1 tissue tissue NOUN dti-1426 34 2 engineering engineering NOUN dti-1426 34 3 of of ADP dti-1426 34 4 vascular vascular ADJ dti-1426 34 5 conduits conduit NOUN dti-1426 34 6 is be AUX dti-1426 34 7 emerging emerge VERB dti-1426 34 8 as as ADP dti-1426 34 9 a a DET dti-1426 34 10 cornerstone cornerstone NOUN dti-1426 34 11 strategy strategy NOUN dti-1426 34 12 to to PART dti-1426 34 13 surmount surmount VERB dti-1426 34 14 the the DET dti-1426 34 15 drawbacks drawback NOUN dti-1426 34 16 experienced experience VERB dti-1426 34 17 with with ADP dti-1426 34 18 surgical surgical ADJ dti-1426 34 19 replacement replacement NOUN dti-1426 34 20 with with ADP dti-1426 34 21 autologous autologous ADJ dti-1426 34 22 vessels vessel NOUN dti-1426 34 23 , , PUNCT dti-1426 34 24 allografts allograft NOUN dti-1426 34 25 or or CCONJ dti-1426 34 26 xenografts xenograft NOUN dti-1426 34 27 , , PUNCT dti-1426 34 28 and and CCONJ dti-1426 34 29 prosthetic prosthetic ADJ dti-1426 34 30 materials.1,2 materials.1,2 ADJ dti-1426 34 31 tissue tissue NOUN dti-1426 34 32 - - PUNCT dti-1426 34 33 engineered engineer VERB dti-1426 34 34 vascular vascular NOUN dti-1426 34 35 graft graft NOUN dti-1426 34 36 ( ( PUNCT dti-1426 34 37 tevg tevg PROPN dti-1426 34 38 ) ) PUNCT dti-1426 34 39 is be AUX dti-1426 34 40 emerging emerge VERB dti-1426 34 41 as as ADP dti-1426 34 42 a a DET dti-1426 34 43 valid valid ADJ dti-1426 34 44 alternative alternative NOUN dti-1426 34 45 to to ADP dti-1426 34 46 routinely routinely ADV dti-1426 34 47 used use VERB dti-1426 34 48 vascular vascular ADJ dti-1426 34 49 prostheses prosthesis NOUN dti-1426 34 50 . . PUNCT dti-1426 35 1 tevg tevg PROPN dti-1426 35 2 constructs construct NOUN dti-1426 35 3 are be AUX dti-1426 35 4 based base VERB dti-1426 35 5 on on ADP dti-1426 35 6 the the DET dti-1426 35 7 use use NOUN dti-1426 35 8 of of ADP dti-1426 35 9 biodegradable biodegradable ADJ dti-1426 35 10 polymeric polymeric ADJ dti-1426 35 11 scaffolds scaffold NOUN dti-1426 35 12 that that PRON dti-1426 35 13 are be AUX dti-1426 35 14 used use VERB dti-1426 35 15 as as ADP dti-1426 35 16 frameworks framework NOUN dti-1426 35 17 for for ADP dti-1426 35 18 autologous autologous ADJ dti-1426 35 19 vascular vascular ADJ dti-1426 35 20 wall wall NOUN dti-1426 35 21 cells cell NOUN dti-1426 35 22 seeding seed VERB dti-1426 35 23 and and CCONJ dti-1426 35 24 culturing.3 culturing.3 PROPN dti-1426 35 25 animal animal NOUN dti-1426 35 26 studies study NOUN dti-1426 35 27 and and CCONJ dti-1426 35 28 human human ADJ dti-1426 35 29 trials trial NOUN dti-1426 35 30 demonstrated demonstrate VERB dti-1426 35 31 the the DET dti-1426 35 32 effectiveness effectiveness NOUN dti-1426 35 33 of of ADP dti-1426 35 34 tevgs tevg NOUN dti-1426 35 35 in in ADP dti-1426 35 36 vascular vascular ADJ dti-1426 35 37 replacement replacement NOUN dti-1426 35 38 for for ADP dti-1426 35 39 both both DET dti-1426 35 40 large(∅ large(∅ ADJ dti-1426 35 41     SPACE dti-1426 35 42 . . PUNCT dti-1426 35 43     SPACE dti-1426 36 1 6 6 NUM dti-1426 36 2     SPACE dti-1426 36 3 mm)4 mm)4 ADJ dti-1426 36 4 and and CCONJ dti-1426 36 5 small small ADJ dti-1426 36 6 - - PUNCT dti-1426 36 7 diameter diameter NOUN dti-1426 36 8 vessels vessel NOUN dti-1426 36 9 ( ( PUNCT dti-1426 36 10 ∅ ∅ NOUN dti-1426 36 11     SPACE dti-1426 36 12 , , PUNCT dti-1426 36 13     SPACE dti-1426 36 14 4 4 NUM dti-1426 36 15     SPACE dti-1426 36 16 mm).5 mm).5 PROPN dti-1426 36 17 tevgs tevg NOUN dti-1426 36 18 seeded seed VERB dti-1426 36 19 with with ADP dti-1426 36 20 autologous autologous ADJ dti-1426 36 21 cells cell NOUN dti-1426 36 22 showed show VERB dti-1426 36 23 efficient efficient ADJ dti-1426 36 24 endothelialization endothelialization NOUN dti-1426 36 25 , , PUNCT dti-1426 36 26 stability stability NOUN dti-1426 36 27 over over ADP dti-1426 36 28 time time NOUN dti-1426 36 29 , , PUNCT dti-1426 36 30 and and CCONJ dti-1426 36 31 freedom freedom NOUN dti-1426 36 32 from from ADP dti-1426 36 33 infections infection NOUN dti-1426 36 34 . . PUNCT dti-1426 37 1 however however ADV dti-1426 37 2 , , PUNCT dti-1426 37 3 several several ADJ dti-1426 37 4 issues issue NOUN dti-1426 37 5 concerning concern VERB dti-1426 37 6 the the DET dti-1426 37 7 clinical clinical ADJ dti-1426 37 8 applications application NOUN dti-1426 37 9 of of ADP dti-1426 37 10 tevg tevg PROPN dti-1426 37 11 still still ADV dti-1426 37 12 need need VERB dti-1426 37 13 to to PART dti-1426 37 14 be be AUX dti-1426 37 15 answered answer VERB dti-1426 37 16 . . PUNCT dti-1426 38 1 reasonable reasonable ADJ dti-1426 38 2 and and CCONJ dti-1426 38 3 clinically clinically ADV dti-1426 38 4 suitable suitable ADJ dti-1426 38 5 timing timing NOUN dti-1426 38 6 for for ADP dti-1426 38 7 scaffold scaffold NOUN dti-1426 38 8 preparation preparation NOUN dti-1426 38 9 , , PUNCT dti-1426 38 10 mechanical mechanical ADJ dti-1426 38 11 properties property NOUN dti-1426 38 12 , , PUNCT dti-1426 38 13 cell cell NOUN dti-1426 38 14 type type NOUN dti-1426 38 15 , , PUNCT dti-1426 38 16 differentiation differentiation NOUN dti-1426 38 17 and and CCONJ dti-1426 38 18 growth growth NOUN dti-1426 38 19 inside inside ADP dti-1426 38 20 the the DET dti-1426 38 21 construct construct NOUN dti-1426 38 22 , , PUNCT dti-1426 38 23 donor donor NOUN dti-1426 38 24 scarcity scarcity NOUN dti-1426 38 25 , , PUNCT dti-1426 38 26 and and CCONJ dti-1426 38 27 thrombogenicity thrombogenicity NOUN dti-1426 38 28 represent represent VERB dti-1426 38 29 the the DET dti-1426 38 30 major major ADJ dti-1426 38 31 concerns concern NOUN dti-1426 38 32 . . PUNCT dti-1426 39 1 the the DET dti-1426 39 2 minimum minimum ADJ dti-1426 39 3 time time NOUN dti-1426 39 4 from from ADP dti-1426 39 5 harvest harvest NOUN dti-1426 39 6 of of ADP dti-1426 39 7 autologous autologous ADJ dti-1426 39 8 cells cell NOUN dti-1426 39 9 to to ADP dti-1426 39 10 the the DET dti-1426 39 11 generation generation NOUN dti-1426 39 12 of of ADP dti-1426 39 13 a a DET dti-1426 39 14 mature mature ADJ dti-1426 39 15 and and CCONJ dti-1426 39 16 durable durable ADJ dti-1426 39 17 conduit conduit NOUN dti-1426 39 18 is be AUX dti-1426 39 19 approximately approximately ADV dti-1426 39 20 eight eight NUM dti-1426 39 21 weeks.6,7 weeks.6,7 PROPN dti-1426 39 22 this this PRON dti-1426 39 23 limits limit VERB dti-1426 39 24 the the DET dti-1426 39 25 use use NOUN dti-1426 39 26 of of ADP dti-1426 39 27 such such ADJ dti-1426 39 28 conduits conduit NOUN dti-1426 39 29 to to ADP dti-1426 39 30 elective elective ADJ dti-1426 39 31 procedures procedure NOUN dti-1426 39 32 and and CCONJ dti-1426 39 33 requires require VERB dti-1426 39 34 local local ADJ dti-1426 39 35 expertise expertise NOUN dti-1426 39 36 and and CCONJ dti-1426 39 37 bioreactor bioreactor NOUN dti-1426 39 38 facilities facility NOUN dti-1426 39 39 . . PUNCT dti-1426 40 1 moreover moreover ADV dti-1426 40 2 issues issue NOUN dti-1426 40 3 concerning concern VERB dti-1426 40 4 the the DET dti-1426 40 5 patency patency NOUN dti-1426 40 6 rate rate NOUN dti-1426 40 7 of of ADP dti-1426 40 8 the the DET dti-1426 40 9 graft graft NOUN dti-1426 40 10 should should AUX dti-1426 40 11 be be AUX dti-1426 40 12 considered consider VERB dti-1426 40 13 as as SCONJ dti-1426 40 14 the the DET dti-1426 40 15 use use NOUN dti-1426 40 16 of of ADP dti-1426 40 17 engineered engineer VERB dti-1426 40 18 scaffold scaffold NOUN dti-1426 40 19 or or CCONJ dti-1426 40 20 even even ADV dti-1426 40 21 small small ADJ dti-1426 40 22 intestine intestine NOUN dti-1426 40 23 submucosa submucosa NOUN dti-1426 40 24 in in ADP dti-1426 40 25 several several ADJ dti-1426 40 26 animal animal NOUN dti-1426 40 27 models model NOUN dti-1426 40 28 has have AUX dti-1426 40 29 been be AUX dti-1426 40 30 shown show VERB dti-1426 40 31 an an DET dti-1426 40 32 journal journal NOUN dti-1426 40 33 name name NOUN dti-1426 40 34 : : PUNCT dti-1426 40 35 drug drug NOUN dti-1426 40 36 target target NOUN dti-1426 40 37 insights insight NOUN dti-1426 40 38 journal journal NOUN dti-1426 40 39 type type NOUN dti-1426 40 40 : : PUNCT dti-1426 40 41 original original ADJ dti-1426 40 42 research research NOUN dti-1426 40 43 year year NOUN dti-1426 40 44 : : PUNCT dti-1426 40 45 2015 2015 NUM dti-1426 40 46 volume volume NOUN dti-1426 40 47 : : PUNCT dti-1426 40 48 9(s1 9(s1 X dti-1426 40 49 ) ) PUNCT dti-1426 40 50 running run VERB dti-1426 40 51 head head NOUN dti-1426 40 52 verso verso ADJ dti-1426 40 53 : : PUNCT dti-1426 40 54 spadaccio spadaccio NOUN dti-1426 40 55 et et PROPN dti-1426 40 56 al al PROPN dti-1426 40 57 running run VERB dti-1426 40 58 head head NOUN dti-1426 40 59 recto recto NOUN dti-1426 40 60 : : PUNCT dti-1426 40 61 hybrid hybrid ADJ dti-1426 40 62 armored armored ADJ dti-1426 40 63 vascular vascular ADJ dti-1426 40 64 graft graft NOUN dti-1426 40 65 manufacturing manufacturing NOUN dti-1426 40 66 techniques technique NOUN dti-1426 40 67 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 NOUN dti-1426 40 68 http://www.la-press.com http://www.la-press.com X dti-1426 41 1 http://dx.doi.org/10.4137/dti.s35202 http://dx.doi.org/10.4137/dti.s35202 ADV dti-1426 41 2 http://creativecommons.org/licenses/by-nc/3.0/ http://creativecommons.org/licenses/by-nc/3.0/ PROPN dti-1426 41 3 http://creativecommons.org/licenses/by-nc/3.0/ http://creativecommons.org/licenses/by-nc/3.0/ PROPN dti-1426 41 4 mailto:cristiano.spadaccio@gjnh.scot.nhs.uk mailto:cristiano.spadaccio@gjnh.scot.nhs.uk NOUN dti-1426 41 5 http://www.la-press.com http://www.la-press.com X dti-1426 41 6 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1426 41 7 spadaccio spadaccio PROPN dti-1426 41 8 et et PROPN dti-1426 41 9 al al PROPN dti-1426 41 10 2 2 NUM dti-1426 41 11 drug drug NOUN dti-1426 41 12 target target NOUN dti-1426 41 13 insights insight NOUN dti-1426 41 14 2016:10(s1 2016:10(s1 NUM dti-1426 41 15 ) ) PUNCT dti-1426 41 16 overall overall ADJ dti-1426 41 17 patency patency NOUN dti-1426 41 18 rate rate NOUN dti-1426 41 19 of of ADP dti-1426 41 20 75 75 NUM dti-1426 41 21 per per NOUN dti-1426 41 22 cent cent NOUN dti-1426 41 23 ( ( PUNCT dti-1426 41 24 48 48 NUM dti-1426 41 25 weeks week NOUN dti-1426 41 26 ) ) PUNCT dti-1426 41 27 nothwithstanding nothwithstande VERB dti-1426 41 28 aspirin aspirin NOUN dti-1426 41 29 and and CCONJ dti-1426 41 30 warfarin warfarin NOUN dti-1426 41 31 administration.8 administration.8 PROPN dti-1426 41 32 in in ADP dti-1426 41 33 this this DET dti-1426 41 34 context context NOUN dti-1426 41 35 , , PUNCT dti-1426 41 36 bioengineering bioengineere VERB dti-1426 41 37 experimental experimental ADJ dti-1426 41 38 efforts effort NOUN dti-1426 41 39 have have AUX dti-1426 41 40 been be AUX dti-1426 41 41 oriented orient VERB dti-1426 41 42 toward toward ADP dti-1426 41 43 the the DET dti-1426 41 44 fabrication fabrication NOUN dti-1426 41 45 of of ADP dti-1426 41 46 scaffolds scaffold NOUN dti-1426 41 47 behaving behave VERB dti-1426 41 48 as as ADP dti-1426 41 49 biological biological ADJ dti-1426 41 50 equivalents equivalent NOUN dti-1426 41 51 with with ADP dti-1426 41 52 histoarchitecture histoarchitecture NOUN dti-1426 41 53 similar similar ADJ dti-1426 41 54 to to ADP dti-1426 41 55 the the DET dti-1426 41 56 native native ADJ dti-1426 41 57 vessels vessel NOUN dti-1426 41 58 with with ADP dti-1426 41 59 the the DET dti-1426 41 60 aim aim NOUN dti-1426 41 61 to to PART dti-1426 41 62 stimulate stimulate VERB dti-1426 41 63 and and CCONJ dti-1426 41 64 support support VERB dti-1426 41 65 cell cell NOUN dti-1426 41 66 engraftment engraftment NOUN dti-1426 41 67 and and CCONJ dti-1426 41 68 proliferation proliferation NOUN dti-1426 41 69 . . PUNCT dti-1426 42 1 different different ADJ dti-1426 42 2 approaches approach NOUN dti-1426 42 3 to to ADP dti-1426 42 4 the the DET dti-1426 42 5 fabrication fabrication NOUN dti-1426 42 6 of of ADP dti-1426 42 7 tevgs tevg NOUN dti-1426 42 8 have have AUX dti-1426 42 9 been be AUX dti-1426 42 10 described.9 described.9 PROPN dti-1426 42 11 in in ADP dti-1426 42 12 this this DET dti-1426 42 13 context context NOUN dti-1426 42 14 , , PUNCT dti-1426 42 15 electrospinning electrospinne VERB dti-1426 42 16 has have AUX dti-1426 42 17 been be AUX dti-1426 42 18 claimed claim VERB dti-1426 42 19 among among ADP dti-1426 42 20 the the DET dti-1426 42 21 most most ADV dti-1426 42 22 promising promising ADJ dti-1426 42 23 manufacturing manufacturing NOUN dti-1426 42 24 techniques technique NOUN dti-1426 42 25 for for ADP dti-1426 42 26 the the DET dti-1426 42 27 production production NOUN dti-1426 42 28 of of ADP dti-1426 42 29 polymeric polymeric ADJ dti-1426 42 30 fibrillar fibrillar ADJ dti-1426 42 31 meshes mesh NOUN dti-1426 42 32 resembling resemble VERB dti-1426 42 33 the the DET dti-1426 42 34 extracellular extracellular ADJ dti-1426 42 35 matrix matrix NOUN dti-1426 42 36 ( ( PUNCT dti-1426 42 37 ecm ecm PROPN dti-1426 42 38 ) ) PUNCT dti-1426 42 39 organization organization NOUN dti-1426 42 40 with with ADP dti-1426 42 41 fiber fiber NOUN dti-1426 42 42 diameters diameter NOUN dti-1426 42 43 ranging range VERB dti-1426 42 44 in in ADP dti-1426 42 45 the the DET dti-1426 42 46 nanometer nanometer NOUN dti-1426 42 47 or or CCONJ dti-1426 42 48 micrometer micrometer NOUN dti-1426 42 49 scale.10 scale.10 VERB dti-1426 42 50 with with ADP dti-1426 42 51 this this DET dti-1426 42 52 system system NOUN dti-1426 42 53 , , PUNCT dti-1426 42 54 it it PRON dti-1426 42 55 is be AUX dti-1426 42 56 possible possible ADJ dti-1426 42 57 to to PART dti-1426 42 58 manufacture manufacture VERB dti-1426 42 59 interconnected interconnected ADJ dti-1426 42 60 porous porous ADJ dti-1426 42 61 structures structure NOUN dti-1426 42 62 displaying display VERB dti-1426 42 63 desirable desirable ADJ dti-1426 42 64 morphologic morphologic ADJ dti-1426 42 65 characteristics characteristic NOUN dti-1426 42 66 in in ADP dti-1426 42 67 biological biological ADJ dti-1426 42 68 environments environment NOUN dti-1426 42 69 as as ADP dti-1426 42 70 a a DET dti-1426 42 71 high high ADJ dti-1426 42 72 surface surface NOUN dti-1426 42 73 - - PUNCT dti-1426 42 74 to to ADP dti-1426 42 75 - - PUNCT dti-1426 42 76 volume volume NOUN dti-1426 42 77 ratio ratio NOUN dti-1426 42 78 , , PUNCT dti-1426 42 79 as as ADV dti-1426 42 80 well well ADV dti-1426 42 81 as as ADP dti-1426 42 82 a a DET dti-1426 42 83 high high ADJ dti-1426 42 84 permeability.11 permeability.11 NOUN dti-1426 42 85 the the DET dti-1426 42 86 manufacturing manufacturing NOUN dti-1426 42 87 setup setup NOUN dti-1426 42 88 is be AUX dti-1426 42 89 amenable amenable ADJ dti-1426 42 90 to to PART dti-1426 42 91 produce produce VERB dti-1426 42 92 tubular tubular ADJ dti-1426 42 93 shapes10 shapes10 NOUN dti-1426 42 94 and and CCONJ dti-1426 42 95 associated associate VERB dti-1426 42 96 to to ADP dti-1426 42 97 all all DET dti-1426 42 98 the the DET dti-1426 42 99 techniques technique NOUN dti-1426 42 100 of of ADP dti-1426 42 101 cell cell NOUN dti-1426 42 102 seeding.12 seeding.12 NOUN dti-1426 42 103 additionally additionally ADV dti-1426 42 104 , , PUNCT dti-1426 42 105 fibers fiber NOUN dti-1426 42 106 are be AUX dti-1426 42 107 amenable amenable ADJ dti-1426 42 108 to to PART dti-1426 42 109 be be AUX dti-1426 42 110 functionalized functionalize VERB dti-1426 42 111 with with ADP dti-1426 42 112 several several ADJ dti-1426 42 113 compounds compound NOUN dti-1426 42 114 and and CCONJ dti-1426 42 115 growth growth NOUN dti-1426 42 116 factors factor NOUN dti-1426 42 117 without without ADP dti-1426 42 118 impairing impair VERB dti-1426 42 119 their their PRON dti-1426 42 120 biological biological ADJ dti-1426 42 121 function function NOUN dti-1426 42 122 and and CCONJ dti-1426 42 123 activity activity NOUN dti-1426 42 124 . . PUNCT dti-1426 43 1 we we PRON dti-1426 43 2 have have AUX dti-1426 43 3 previously previously ADV dti-1426 43 4 developed develop VERB dti-1426 43 5 poly poly ADJ dti-1426 43 6 - - PUNCT dti-1426 43 7 l l NOUN dti-1426 43 8 - - NOUN dti-1426 43 9 lactide lactide ADJ dti-1426 43 10 ( ( PUNCT dti-1426 43 11 plla plla NOUN dti-1426 43 12 ) ) PUNCT dti-1426 43 13 electrospun electrospun NOUN dti-1426 43 14 tubular tubular ADJ dti-1426 43 15 scaffold scaffold NOUN dti-1426 43 16 functionalized functionalize VERB dti-1426 43 17 with with ADP dti-1426 43 18 heparin heparin NOUN dti-1426 43 19 with with ADP dti-1426 43 20 the the DET dti-1426 43 21 final final ADJ dti-1426 43 22 aim aim NOUN dti-1426 43 23 to to PART dti-1426 43 24 both both CCONJ dti-1426 43 25 assist assist VERB dti-1426 43 26 cell cell NOUN dti-1426 43 27 differentiation differentiation NOUN dti-1426 43 28 and and CCONJ dti-1426 43 29 realize realize VERB dti-1426 43 30 a a DET dti-1426 43 31 drug drug NOUN dti-1426 43 32 delivery delivery NOUN dti-1426 43 33 device device NOUN dti-1426 43 34 to to PART dti-1426 43 35 prevent prevent VERB dti-1426 43 36 graft graft NOUN dti-1426 43 37 thrombosis thrombosis NOUN dti-1426 43 38 with with ADP dti-1426 43 39 encouraging encourage VERB dti-1426 43 40 results.13 results.13 VERB dti-1426 43 41 moreover moreover ADV dti-1426 43 42 , , PUNCT dti-1426 43 43 electrospun electrospun NOUN dti-1426 43 44 scaffolds scaffold NOUN dti-1426 43 45 , , PUNCT dti-1426 43 46 simulating simulate VERB dti-1426 43 47 the the DET dti-1426 43 48 arrangement arrangement NOUN dti-1426 43 49 of of ADP dti-1426 43 50 ecm ecm NOUN dti-1426 43 51 fibrillar fibrillar ADJ dti-1426 43 52 proteins protein NOUN dti-1426 43 53 , , PUNCT dti-1426 43 54 showed show VERB dti-1426 43 55 a a DET dti-1426 43 56 permissive permissive ADJ dti-1426 43 57 effect effect NOUN dti-1426 43 58 on on ADP dti-1426 43 59 vascular vascular ADJ dti-1426 43 60 remodeling remodeling NOUN dti-1426 43 61 of of ADP dti-1426 43 62 both both CCONJ dti-1426 43 63 the the DET dti-1426 43 64 cellular cellular ADJ dti-1426 43 65 and and CCONJ dti-1426 43 66 extracellular extracellular ADJ dti-1426 43 67 components component NOUN dti-1426 43 68 of of ADP dti-1426 43 69 a a DET dti-1426 43 70 graft graft NOUN dti-1426 43 71 , , PUNCT dti-1426 43 72 and and CCONJ dti-1426 43 73 might might AUX dti-1426 43 74 therefore therefore ADV dti-1426 43 75 constitute constitute VERB dti-1426 43 76 a a DET dti-1426 43 77 suitable suitable ADJ dti-1426 43 78 candidate candidate NOUN dti-1426 43 79 for for ADP dti-1426 43 80 tevgs tevgs NOUN dti-1426 43 81 fabrication.14 fabrication.14 NOUN dti-1426 43 82 however however ADV dti-1426 43 83 , , PUNCT dti-1426 43 84 the the DET dti-1426 43 85 ability ability NOUN dti-1426 43 86 to to PART dti-1426 43 87 simulate simulate VERB dti-1426 43 88 biomechanical biomechanical ADJ dti-1426 43 89 characteristics characteristic NOUN dti-1426 43 90 and and CCONJ dti-1426 43 91 behavior behavior NOUN dti-1426 43 92 of of ADP dti-1426 43 93 the the DET dti-1426 43 94 natural natural ADJ dti-1426 43 95 vessel vessel NOUN dti-1426 43 96 wall wall NOUN dti-1426 43 97 represents represent VERB dti-1426 43 98 an an DET dti-1426 43 99 obstacle.15–18 obstacle.15–18 NOUN dti-1426 43 100 despite despite SCONJ dti-1426 43 101 a a DET dti-1426 43 102 number number NOUN dti-1426 43 103 of of ADP dti-1426 43 104 efforts effort NOUN dti-1426 43 105 experimental experimental ADJ dti-1426 43 106 efforts effort NOUN dti-1426 43 107 lavished lavish VERB dti-1426 43 108 in in ADP dti-1426 43 109 this this DET dti-1426 43 110 direction direction NOUN dti-1426 43 111 , , PUNCT dti-1426 43 112 the the DET dti-1426 43 113 mechanical mechanical ADJ dti-1426 43 114 properties property NOUN dti-1426 43 115 of of ADP dti-1426 43 116 electrospun electrospun NOUN dti-1426 43 117 fibrillar fibrillar ADJ dti-1426 43 118 matrices matrix NOUN dti-1426 43 119 are be AUX dti-1426 43 120 still still ADV dti-1426 43 121 inappropriate inappropriate ADJ dti-1426 43 122 to to PART dti-1426 43 123 sustain sustain VERB dti-1426 43 124 the the DET dti-1426 43 125 pressure pressure NOUN dti-1426 43 126 loads load NOUN dti-1426 43 127 soon soon ADV dti-1426 43 128 after after ADP dti-1426 43 129 implantation implantation NOUN dti-1426 43 130 in in ADP dti-1426 43 131 the the DET dti-1426 43 132 vascular vascular ADJ dti-1426 43 133 tree tree NOUN dti-1426 43 134 and and CCONJ dti-1426 43 135 to to PART dti-1426 43 136 ensure ensure VERB dti-1426 43 137 structural structural ADJ dti-1426 43 138 and and CCONJ dti-1426 43 139 functional functional ADJ dti-1426 43 140 integrity integrity NOUN dti-1426 43 141 in in ADP dti-1426 43 142 the the DET dti-1426 43 143 later later ADJ dti-1426 43 144 stages stage NOUN dti-1426 43 145 during during ADP dti-1426 43 146 the the DET dti-1426 43 147 remodeling remodeling NOUN dti-1426 43 148 phases.19 phases.19 NOUN dti-1426 43 149 in in ADP dti-1426 43 150 order order NOUN dti-1426 43 151 to to PART dti-1426 43 152 overcome overcome VERB dti-1426 43 153 this this DET dti-1426 43 154 drawback drawback NOUN dti-1426 43 155 , , PUNCT dti-1426 43 156 we we PRON dti-1426 43 157 recently recently ADV dti-1426 43 158 developed develop VERB dti-1426 43 159 a a DET dti-1426 43 160 hybrid hybrid ADJ dti-1426 43 161 technique technique NOUN dti-1426 43 162 associating associate VERB dti-1426 43 163 electrospinning electrospinne VERB dti-1426 43 164 and and CCONJ dti-1426 43 165 bioprinting bioprinting NOUN dti-1426 43 166 to to PART dti-1426 43 167 fabricate fabricate VERB dti-1426 43 168 a a DET dti-1426 43 169 bioresorbable bioresorbable ADJ dti-1426 43 170 scaffold scaffold NOUN dti-1426 43 171 for for ADP dti-1426 43 172 vascular vascular ADJ dti-1426 43 173 tissue tissue NOUN dti-1426 43 174 engineering engineering NOUN dti-1426 43 175 . . PUNCT dti-1426 44 1 with with ADP dti-1426 44 2 the the DET dti-1426 44 3 aim aim NOUN dti-1426 44 4 to to PART dti-1426 44 5 improve improve VERB dti-1426 44 6 mechanical mechanical ADJ dti-1426 44 7 and and CCONJ dti-1426 44 8 functional functional ADJ dti-1426 44 9 properties property NOUN dti-1426 44 10 of of ADP dti-1426 44 11 the the DET dti-1426 44 12 tevg tevg PROPN dti-1426 44 13 , , PUNCT dti-1426 44 14 a a DET dti-1426 44 15 single single ADJ dti-1426 44 16 - - PUNCT dti-1426 44 17 layer layer NOUN dti-1426 44 18 helical helical ADJ dti-1426 44 19 poly poly ADJ dti-1426 44 20 - - PUNCT dti-1426 44 21 e e NOUN dti-1426 44 22 - - NOUN dti-1426 44 23 caprolactone caprolactone ADJ dti-1426 44 24 ( ( PUNCT dti-1426 44 25 pcl pcl PROPN dti-1426 44 26 ) ) PUNCT dti-1426 44 27 coil coil NOUN dti-1426 44 28 was be AUX dti-1426 44 29 bioprinted bioprinte VERB dti-1426 44 30 on on ADP dti-1426 44 31 the the DET dti-1426 44 32 external external ADJ dti-1426 44 33 surface surface NOUN dti-1426 44 34 as as ADP dti-1426 44 35 a a DET dti-1426 44 36 reinforcement reinforcement NOUN dti-1426 44 37 of of ADP dti-1426 44 38 an an DET dti-1426 44 39 heparin heparin NOUN dti-1426 44 40 - - PUNCT dti-1426 44 41 releasing release VERB dti-1426 44 42 plla plla NOUN dti-1426 44 43 tubular tubular ADJ dti-1426 44 44 electrospun electrospun NOUN dti-1426 44 45 scaffold.20 scaffold.20 PROPN dti-1426 44 46 this this DET dti-1426 44 47 approach approach NOUN dti-1426 44 48 takes take VERB dti-1426 44 49 its its PRON dti-1426 44 50 inspiration inspiration NOUN dti-1426 44 51 from from ADP dti-1426 44 52 the the DET dti-1426 44 53 so so ADV dti-1426 44 54 - - PUNCT dti-1426 44 55 called call VERB dti-1426 44 56 computer computer NOUN dti-1426 44 57 - - PUNCT dti-1426 44 58 aided aid VERB dti-1426 44 59 tissue tissue NOUN dti-1426 44 60 engineering engineering NOUN dti-1426 44 61 ( ( PUNCT dti-1426 44 62 cate cate PROPN dti-1426 44 63 ) ) PUNCT dti-1426 44 64 , , PUNCT dti-1426 44 65 which which PRON dti-1426 44 66 has have AUX dti-1426 44 67 been be AUX dti-1426 44 68 reported report VERB dti-1426 44 69 to to PART dti-1426 44 70 be be AUX dti-1426 44 71 an an DET dti-1426 44 72 exciting exciting ADJ dti-1426 44 73 resource resource NOUN dti-1426 44 74 to to PART dti-1426 44 75 produce produce VERB dti-1426 44 76 three three NUM dti-1426 44 77 - - PUNCT dti-1426 44 78 dimensional dimensional ADJ dti-1426 44 79 ( ( PUNCT dti-1426 44 80 3d 3d NOUN dti-1426 44 81 ) ) PUNCT dti-1426 44 82 geometry geometry NOUN dti-1426 44 83 constructs.21,22 constructs.21,22 NOUN dti-1426 44 84 biofunctionalization biofunctionalization NOUN dti-1426 44 85 with with ADP dti-1426 44 86 heparin heparin NOUN dti-1426 44 87 permitted permit VERB dti-1426 44 88 the the DET dti-1426 44 89 creation creation NOUN dti-1426 44 90 of of ADP dti-1426 44 91 a a DET dti-1426 44 92 drug drug NOUN dti-1426 44 93 delivery delivery NOUN dti-1426 44 94 system system NOUN dti-1426 44 95 that that PRON dti-1426 44 96 could could AUX dti-1426 44 97 overcome overcome VERB dti-1426 44 98 the the DET dti-1426 44 99 thrombogenic thrombogenic ADJ dti-1426 44 100 issues issue NOUN dti-1426 44 101 of of ADP dti-1426 44 102 tevg tevg PROPN dti-1426 44 103 and and CCONJ dti-1426 44 104 at at ADP dti-1426 44 105 the the DET dti-1426 44 106 same same ADJ dti-1426 44 107 time time NOUN dti-1426 44 108 provide provide VERB dti-1426 44 109 a a DET dti-1426 44 110 microenvironment microenvironment NOUN dti-1426 44 111 suitable suitable ADJ dti-1426 44 112 to to PART dti-1426 44 113 stimulate stimulate VERB dti-1426 44 114 endothelial endothelial ADJ dti-1426 44 115 differentiation differentiation NOUN dti-1426 44 116 . . PUNCT dti-1426 45 1 the the DET dti-1426 45 2     SPACE dti-1426 45 3 pcl pcl PROPN dti-1426 45 4 external external PROPN dti-1426 45 5 reinforcement reinforcement NOUN dti-1426 45 6 ameliorated ameliorate VERB dti-1426 45 7 the the DET dti-1426 45 8 resistance resistance NOUN dti-1426 45 9 to to ADP dti-1426 45 10 mechanical mechanical ADJ dti-1426 45 11 stress stress NOUN dti-1426 45 12 of of ADP dti-1426 45 13 the the DET dti-1426 45 14 scaffold scaffold NOUN dti-1426 45 15 in in ADP dti-1426 45 16 comparison comparison NOUN dti-1426 45 17 to to ADP dti-1426 45 18 nonarmored nonarmore VERB dti-1426 45 19 grafts graft NOUN dti-1426 45 20 , , PUNCT dti-1426 45 21 and and CCONJ dti-1426 45 22 more more ADV dti-1426 45 23 interestingly interestingly ADV dti-1426 45 24 , , PUNCT dti-1426 45 25 when when SCONJ dti-1426 45 26 compared compare VERB dti-1426 45 27 to to ADP dti-1426 45 28 autologous autologous ADJ dti-1426 45 29 conduits conduit NOUN dti-1426 45 30 , , PUNCT dti-1426 45 31 it it PRON dti-1426 45 32 showed show VERB dti-1426 45 33 better well ADJ dti-1426 45 34 mechanical mechanical ADJ dti-1426 45 35 properties property NOUN dti-1426 45 36 and and CCONJ dti-1426 45 37 stress stress NOUN dti-1426 45 38 – – PUNCT dti-1426 45 39 strain strain NOUN dti-1426 45 40 profile profile NOUN dti-1426 45 41 than than ADP dti-1426 45 42 a a DET dti-1426 45 43 human human ADJ dti-1426 45 44 saphenous saphenous ADJ dti-1426 45 45 vein vein NOUN dti-1426 45 46 while while SCONJ dti-1426 45 47 approximating approximate VERB dti-1426 45 48 to to ADP dti-1426 45 49 the the DET dti-1426 45 50 ones one NOUN dti-1426 45 51 of of ADP dti-1426 45 52 the the DET dti-1426 45 53 internal internal ADJ dti-1426 45 54 thoracic thoracic NOUN dti-1426 45 55 artery artery NOUN dti-1426 45 56 . . PUNCT dti-1426 46 1 additionally additionally ADV dti-1426 46 2 , , PUNCT dti-1426 46 3 it it PRON dti-1426 46 4 preserved preserve VERB dti-1426 46 5 the the DET dti-1426 46 6 fibrillar fibrillar ADJ dti-1426 46 7 ecm ecm NOUN dti-1426 46 8 - - PUNCT dti-1426 46 9 like like ADJ dti-1426 46 10 arrangement arrangement NOUN dti-1426 46 11 optimal optimal ADJ dti-1426 46 12 for for ADP dti-1426 46 13 initial initial ADJ dti-1426 46 14 cell cell NOUN dti-1426 46 15 attachment attachment NOUN dti-1426 46 16 and and CCONJ dti-1426 46 17 was be AUX dti-1426 46 18 able able ADJ dti-1426 46 19 to to PART dti-1426 46 20 stimulate stimulate VERB dti-1426 46 21 the the DET dti-1426 46 22 engraftment engraftment NOUN dti-1426 46 23 , , PUNCT dti-1426 46 24 proliferation proliferation NOUN dti-1426 46 25 , , PUNCT dti-1426 46 26 and and CCONJ dti-1426 46 27 endothelial endothelial ADJ dti-1426 46 28 differentiation differentiation NOUN dti-1426 46 29 of of ADP dti-1426 46 30 human human ADJ dti-1426 46 31 bone bone NOUN dti-1426 46 32 marrow marrow NOUN dti-1426 46 33 - - PUNCT dti-1426 46 34 derived derive VERB dti-1426 46 35 mesenchymal mesenchymal NOUN dti-1426 46 36 stem stem NOUN dti-1426 46 37 cells cell NOUN dti-1426 46 38 . . PUNCT dti-1426 47 1 to to ADP dti-1426 47 2 our our PRON dti-1426 47 3 knowledge knowledge NOUN dti-1426 47 4 , , PUNCT dti-1426 47 5 no no DET dti-1426 47 6 other other ADJ dti-1426 47 7 approaches approach NOUN dti-1426 47 8 combining combine VERB dti-1426 47 9 a a DET dti-1426 47 10 heparinreleasing heparinrelease VERB dti-1426 47 11 plla plla NOUN dti-1426 47 12 electrospun electrospun NOUN dti-1426 47 13 scaffold scaffold NOUN dti-1426 47 14 with with ADP dti-1426 47 15 a a DET dti-1426 47 16 bioprinted bioprinte VERB dti-1426 47 17 pcl pcl PROPN dti-1426 47 18 armor armor NOUN dti-1426 47 19 have have AUX dti-1426 47 20 been be AUX dti-1426 47 21 proposed propose VERB dti-1426 47 22 in in ADP dti-1426 47 23 the the DET dti-1426 47 24 literature literature NOUN dti-1426 47 25 . . PUNCT dti-1426 48 1 on on ADP dti-1426 48 2 the the DET dti-1426 48 3 basis basis NOUN dti-1426 48 4 of of ADP dti-1426 48 5 these these DET dti-1426 48 6 experimental experimental ADJ dti-1426 48 7 results result NOUN dti-1426 48 8 , , PUNCT dti-1426 48 9 we we PRON dti-1426 48 10 decided decide VERB dti-1426 48 11 to to PART dti-1426 48 12 perform perform VERB dti-1426 48 13 a a DET dti-1426 48 14 preliminary preliminary ADJ dti-1426 48 15 proof proof NOUN dti-1426 48 16 - - PUNCT dti-1426 48 17 of of ADP dti-1426 48 18 - - PUNCT dti-1426 48 19 principle principle NOUN dti-1426 48 20 study study NOUN dti-1426 48 21 to to PART dti-1426 48 22 test test VERB dti-1426 48 23 the the DET dti-1426 48 24 effectiveness effectiveness NOUN dti-1426 48 25 of of ADP dti-1426 48 26 the the DET dti-1426 48 27 previously previously ADV dti-1426 48 28 developed develop VERB dti-1426 48 29 tevg tevg PROPN dti-1426 48 30 in in ADP dti-1426 48 31 an an DET dti-1426 48 32 in in ADP dti-1426 48 33 vivo vivo ADJ dti-1426 48 34 rabbit rabbit NOUN dti-1426 48 35 model model NOUN dti-1426 48 36 of of ADP dti-1426 48 37 aortoaortic aortoaortic ADJ dti-1426 48 38 vascular vascular ADJ dti-1426 48 39 bypass bypass NOUN dti-1426 48 40 . . PUNCT dti-1426 49 1 materials material NOUN dti-1426 49 2 and and CCONJ dti-1426 49 3 methods method NOUN dti-1426 49 4 fabrication fabrication NOUN dti-1426 49 5 of of ADP dti-1426 49 6 the the DET dti-1426 49 7 graft graft NOUN dti-1426 49 8 . . PUNCT dti-1426 50 1 armored armored ADJ dti-1426 50 2 vascular vascular ADJ dti-1426 50 3 grafts graft NOUN dti-1426 50 4 were be AUX dti-1426 50 5 prepared prepare VERB dti-1426 50 6 as as ADP dti-1426 50 7 previously previously ADV dti-1426 50 8 described.20 described.20 NUM dti-1426 50 9 briefly briefly ADV dti-1426 50 10 , , PUNCT dti-1426 50 11 a a DET dti-1426 50 12 13 13 NUM dti-1426 50 13 % % NOUN dti-1426 50 14     SPACE dti-1426 50 15 w w PROPN dti-1426 50 16 / / SYM dti-1426 50 17 w w NOUN dti-1426 50 18 plla plla NOUN dti-1426 50 19 ( ( PUNCT dti-1426 50 20 sigma sigma PROPN dti-1426 50 21 - - PUNCT dti-1426 50 22 aldrich aldrich NOUN dti-1426 50 23 ) ) PUNCT dti-1426 50 24 solution solution NOUN dti-1426 50 25 in in ADP dti-1426 50 26 dichloromethane dichloromethane NOUN dti-1426 50 27 was be AUX dti-1426 50 28 combined combine VERB dti-1426 50 29 with with ADP dti-1426 50 30 unfractioned unfractioned ADJ dti-1426 50 31 heparin heparin NOUN dti-1426 50 32 ( ( PUNCT dti-1426 50 33 sodium sodium NOUN dti-1426 50 34 salt salt NOUN dti-1426 50 35 , , PUNCT dti-1426 50 36 5000 5000 NUM dti-1426 50 37     SPACE dti-1426 50 38 ui ui PROPN dti-1426 50 39 / / SYM dti-1426 50 40 ml ml PROPN dti-1426 50 41 ; ; PUNCT dti-1426 50 42 mspharma mspharma NOUN dti-1426 50 43 ) ) PUNCT dti-1426 50 44 using use VERB dti-1426 50 45 methanol methanol NOUN dti-1426 50 46 as as ADP dti-1426 50 47 a a DET dti-1426 50 48 cosolvent cosolvent NOUN dti-1426 50 49 . . PUNCT dti-1426 51 1 a a DET dti-1426 51 2 final final ADJ dti-1426 51 3 concentration concentration NOUN dti-1426 51 4 of of ADP dti-1426 51 5 heparin heparin NOUN dti-1426 51 6 ( ( PUNCT dti-1426 51 7 with with ADP dti-1426 51 8 respect respect NOUN dti-1426 51 9 to to ADP dti-1426 51 10 plla plla NOUN dti-1426 51 11 ) ) PUNCT dti-1426 51 12 of of ADP dti-1426 51 13 830 830 NUM dti-1426 51 14     SPACE dti-1426 51 15 mg mg PROPN dti-1426 51 16 / / SYM dti-1426 51 17 g g PROPN dti-1426 51 18 was be AUX dti-1426 51 19 obtained obtain VERB dti-1426 51 20 , , PUNCT dti-1426 51 21 corresponding correspond VERB dti-1426 51 22 to to ADP dti-1426 51 23 the the DET dti-1426 51 24 dosage dosage NOUN dti-1426 51 25 routinely routinely ADV dti-1426 51 26 used use VERB dti-1426 51 27 in in ADP dti-1426 51 28 literature literature NOUN dti-1426 51 29 and and CCONJ dti-1426 51 30 clinical clinical ADJ dti-1426 51 31 settings.23 settings.23 PROPN dti-1426 51 32 a a DET dti-1426 51 33 tubular tubular ADJ dti-1426 51 34 scaffold scaffold NOUN dti-1426 51 35 , , PUNCT dti-1426 51 36 5 5 NUM dti-1426 51 37     SPACE dti-1426 51 38 mm mm PROPN dti-1426 51 39 in in ADP dti-1426 51 40 diameter diameter NOUN dti-1426 51 41 and and CCONJ dti-1426 51 42 6 6 NUM dti-1426 51 43     SPACE dti-1426 51 44 cm cm NOUN dti-1426 51 45 in in ADP dti-1426 51 46 length length NOUN dti-1426 51 47 , , PUNCT dti-1426 51 48 was be AUX dti-1426 51 49 manufactured manufacture VERB dti-1426 51 50 by by ADP dti-1426 51 51 means mean NOUN dti-1426 51 52 of of ADP dti-1426 51 53 electrospinning electrospinne VERB dti-1426 51 54 according accord VERB dti-1426 51 55 to to ADP dti-1426 51 56 previously previously ADV dti-1426 51 57 described describe VERB dti-1426 51 58 methods.13,20 methods.13,20 NOUN dti-1426 51 59 subsequently subsequently ADV dti-1426 51 60 , , PUNCT dti-1426 51 61 an an DET dti-1426 51 62 outer outer ADJ dti-1426 51 63 pcl pcl PROPN dti-1426 51 64 ( ( PUNCT dti-1426 51 65 mw mw PROPN dti-1426 51 66 80 80 NUM dti-1426 51 67     SPACE dti-1426 51 68 kda kda NOUN dti-1426 51 69 ; ; PUNCT dti-1426 51 70 sigmaaldrich sigmaaldrich ADJ dti-1426 51 71 ) ) PUNCT dti-1426 51 72 armor armor NOUN dti-1426 51 73 was be AUX dti-1426 51 74 constructed construct VERB dti-1426 51 75 by by ADP dti-1426 51 76 fusion fusion NOUN dti-1426 51 77 deposition deposition NOUN dti-1426 51 78 modeling modeling NOUN dti-1426 51 79 techniques technique NOUN dti-1426 51 80 using use VERB dti-1426 51 81 a a DET dti-1426 51 82 previously previously ADV dti-1426 51 83 developed develop VERB dti-1426 51 84 bioprinter.20 bioprinter.20 PROPN dti-1426 51 85 a a DET dti-1426 51 86 detailed detailed ADJ dti-1426 51 87 description description NOUN dti-1426 51 88 of of ADP dti-1426 51 89 the the DET dti-1426 51 90 morphological morphological ADJ dti-1426 51 91 and and CCONJ dti-1426 51 92 mechanical mechanical ADJ dti-1426 51 93 characterization characterization NOUN dti-1426 51 94 of of ADP dti-1426 51 95 the the DET dti-1426 51 96 graft graft NOUN dti-1426 51 97 is be AUX dti-1426 51 98 reported report VERB dti-1426 51 99 elsewhere.20 elsewhere.20 PROPN dti-1426 51 100 in in ADP dti-1426 51 101 vivo vivo ADJ dti-1426 51 102 experimental experimental ADJ dti-1426 51 103 design design NOUN dti-1426 51 104 and and CCONJ dti-1426 51 105 surgical surgical ADJ dti-1426 51 106 procedure procedure NOUN dti-1426 51 107 . . PUNCT dti-1426 52 1 a a DET dti-1426 52 2 modified modify VERB dti-1426 52 3 model model NOUN dti-1426 52 4 of of ADP dti-1426 52 5 abdominal abdominal ADJ dti-1426 52 6 aorta aorta NOUN dti-1426 52 7 vascular vascular NOUN dti-1426 52 8 reconstruction reconstruction NOUN dti-1426 52 9 was be AUX dti-1426 52 10 performed perform VERB dti-1426 52 11 according accord VERB dti-1426 52 12 to to ADP dti-1426 52 13 previously previously ADV dti-1426 52 14 described describe VERB dti-1426 52 15 protocols protocol NOUN dti-1426 52 16 ( ( PUNCT dti-1426 52 17 fig fig NOUN dti-1426 52 18 . . PUNCT dti-1426 53 1 1).24 1).24 NUM dti-1426 53 2 a a DET dti-1426 53 3 total total NOUN dti-1426 53 4 of of ADP dti-1426 53 5 10 10 NUM dti-1426 53 6 adult adult NOUN dti-1426 53 7 male male NOUN dti-1426 53 8 new new PROPN dti-1426 53 9 zealand zealand PROPN dti-1426 53 10 white white PROPN dti-1426 53 11 rabbits rabbit NOUN dti-1426 53 12 weighting weight VERB dti-1426 53 13 1.8–2.1 1.8–2.1 NOUN dti-1426 53 14     SPACE dti-1426 53 15 kg kg NOUN dti-1426 53 16 were be AUX dti-1426 53 17 purchased purchase VERB dti-1426 53 18 ( ( PUNCT dti-1426 53 19 charles charles PROPN dti-1426 53 20 river river PROPN dti-1426 53 21 laboratory laboratory PROPN dti-1426 53 22 ) ) PUNCT dti-1426 53 23 and and CCONJ dti-1426 53 24 housed house VERB dti-1426 53 25 under under ADP dti-1426 53 26 controlled control VERB dti-1426 53 27 conditions condition NOUN dti-1426 53 28 and and CCONJ dti-1426 53 29 normal normal ADJ dti-1426 53 30 diet diet NOUN dti-1426 53 31 for for ADP dti-1426 53 32 three three NUM dti-1426 53 33 weeks week NOUN dti-1426 53 34 before before ADP dti-1426 53 35 experimentation experimentation NOUN dti-1426 53 36 . . PUNCT dti-1426 54 1 all all DET dti-1426 54 2 animals animal NOUN dti-1426 54 3 were be AUX dti-1426 54 4 implanted implant VERB dti-1426 54 5 with with ADP dti-1426 54 6 a a DET dti-1426 54 7 pcl pcl NOUN dti-1426 54 8 - - PUNCT dti-1426 54 9 armored armor VERB dti-1426 54 10 heparin heparin NOUN dti-1426 54 11 - - PUNCT dti-1426 54 12 releasing release VERB dti-1426 54 13 plla plla NOUN dti-1426 54 14 tubular tubular ADJ dti-1426 54 15 scaffold scaffold NOUN dti-1426 54 16 according accord VERB dti-1426 54 17 to to ADP dti-1426 54 18 the the DET dti-1426 54 19 procedure procedure NOUN dti-1426 54 20 further far ADV dti-1426 54 21 described describe VERB dti-1426 54 22 . . PUNCT dti-1426 55 1 the the DET dti-1426 55 2 study study NOUN dti-1426 55 3 design design NOUN dti-1426 55 4 did do AUX dti-1426 55 5 not not PART dti-1426 55 6 include include VERB dti-1426 55 7 a a DET dti-1426 55 8 control control NOUN dti-1426 55 9 graft graft NOUN dti-1426 55 10 without without ADP dti-1426 55 11 heparin heparin ADJ dti-1426 55 12 loading loading NOUN dti-1426 55 13 , , PUNCT dti-1426 55 14 as as SCONJ dti-1426 55 15 previous previous ADJ dti-1426 55 16 preliminary preliminary ADJ dti-1426 55 17 experiments experiment NOUN dti-1426 55 18 using use VERB dti-1426 55 19 pclarmored pclarmore VERB dti-1426 55 20 plla plla NOUN dti-1426 55 21 grafts graft NOUN dti-1426 55 22 showed show VERB dti-1426 55 23 an an DET dti-1426 55 24 excessively excessively ADV dti-1426 55 25 low low ADJ dti-1426 55 26 patency patency NOUN dti-1426 55 27 rate rate NOUN dti-1426 55 28 due due ADP dti-1426 55 29 to to ADP dti-1426 55 30 acute acute ADJ dti-1426 55 31 graft graft NOUN dti-1426 55 32 thrombotic thrombotic ADJ dti-1426 55 33 occlusion occlusion NOUN dti-1426 55 34 . . PUNCT dti-1426 56 1 additionally additionally ADV dti-1426 56 2 , , PUNCT dti-1426 56 3 nonarmored nonarmore VERB dti-1426 56 4 plla plla NOUN dti-1426 56 5 tubular tubular ADJ dti-1426 56 6 grafts graft NOUN dti-1426 56 7 showed show VERB dti-1426 56 8 no no DET dti-1426 56 9 adequate adequate ADJ dti-1426 56 10 mechanical mechanical ADJ dti-1426 56 11 properties property NOUN dti-1426 56 12 to to PART dti-1426 56 13 support support VERB dti-1426 56 14 flow flow NOUN dti-1426 56 15 after after ADP dti-1426 56 16 implantation implantation NOUN dti-1426 56 17 . . PUNCT dti-1426 57 1 considering consider VERB dti-1426 57 2 the the DET dti-1426 57 3 preliminary preliminary ADJ dti-1426 57 4 nature nature NOUN dti-1426 57 5 of of ADP dti-1426 57 6 this this DET dti-1426 57 7 study study NOUN dti-1426 57 8 , , PUNCT dti-1426 57 9 designed design VERB dti-1426 57 10 as as ADP dti-1426 57 11 a a DET dti-1426 57 12 proofof proofof NOUN dti-1426 57 13 - - PUNCT dti-1426 57 14 principle principle NOUN dti-1426 57 15 to to PART dti-1426 57 16 test test NOUN dti-1426 57 17 effectiveness effectiveness NOUN dti-1426 57 18 of of ADP dti-1426 57 19 the the DET dti-1426 57 20 newly newly ADV dti-1426 57 21 developed develop VERB dti-1426 57 22 armored armored ADJ dti-1426 57 23 heparin heparin NOUN dti-1426 57 24 - - PUNCT dti-1426 57 25 releasing releasing NOUN dti-1426 57 26 scaffold scaffold NOUN dti-1426 57 27 , , PUNCT dti-1426 57 28 we we PRON dti-1426 57 29 decided decide VERB dti-1426 57 30 to to PART dti-1426 57 31 not not PART dti-1426 57 32 include include VERB dti-1426 57 33 control control NOUN dti-1426 57 34 groups group NOUN dti-1426 57 35 which which PRON dti-1426 57 36 would would AUX dti-1426 57 37 have have AUX dti-1426 57 38 been be AUX dti-1426 57 39 certainly certainly ADV dti-1426 57 40 inferior inferior ADJ dti-1426 57 41 in in ADP dti-1426 57 42 http://www.la-press.com http://www.la-press.com X dti-1426 57 43 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1426 57 44 hybrid hybrid ADJ dti-1426 57 45 armored armored ADJ dti-1426 57 46 vascular vascular ADJ dti-1426 57 47 graft graft NOUN dti-1426 57 48 manufacturing manufacturing NOUN dti-1426 57 49 techniques technique NOUN dti-1426 57 50 3drug 3drug NUM dti-1426 57 51 target target NOUN dti-1426 57 52 insights insight NOUN dti-1426 57 53 2016:10(s1 2016:10(s1 NUM dti-1426 57 54 ) ) PUNCT dti-1426 57 55 performance performance NOUN dti-1426 57 56 to to ADP dti-1426 57 57 the the DET dti-1426 57 58 study study NOUN dti-1426 57 59 group group NOUN dti-1426 57 60 . . PUNCT dti-1426 58 1 all all DET dti-1426 58 2 procedures procedure NOUN dti-1426 58 3 , , PUNCT dti-1426 58 4 care care NOUN dti-1426 58 5 , , PUNCT dti-1426 58 6 and and CCONJ dti-1426 58 7 handling handling NOUN dti-1426 58 8 of of ADP dti-1426 58 9 the the DET dti-1426 58 10 animals animal NOUN dti-1426 58 11 were be AUX dti-1426 58 12 reviewed review VERB dti-1426 58 13 and and CCONJ dti-1426 58 14 approved approve VERB dti-1426 58 15 by by ADP dti-1426 58 16 the the DET dti-1426 58 17 institutional institutional ADJ dti-1426 58 18 animal animal NOUN dti-1426 58 19 care care NOUN dti-1426 58 20 and and CCONJ dti-1426 58 21 use use VERB dti-1426 58 22 committee committee NOUN dti-1426 58 23 of of ADP dti-1426 58 24 the the DET dti-1426 58 25 regina regina PROPN dti-1426 58 26 elena elena PROPN dti-1426 58 27 institute institute PROPN dti-1426 58 28 . . PUNCT dti-1426 59 1 an an DET dti-1426 59 2 optimized optimize VERB dti-1426 59 3 anesthesia anesthesia NOUN dti-1426 59 4 protocol protocol NOUN dti-1426 59 5 was be AUX dti-1426 59 6 selected select VERB dti-1426 59 7 in in SCONJ dti-1426 59 8 order order NOUN dti-1426 59 9 to to PART dti-1426 59 10 guarantee guarantee VERB dti-1426 59 11 stabilization stabilization NOUN dti-1426 59 12 of of ADP dti-1426 59 13 cardiovascular cardiovascular ADJ dti-1426 59 14 function function NOUN dti-1426 59 15 during during ADP dti-1426 59 16 the the DET dti-1426 59 17 open open ADJ dti-1426 59 18 chest chest NOUN dti-1426 59 19 procedure.25 procedure.25 VERB dti-1426 59 20 anesthesia anesthesia PROPN dti-1426 59 21 was be AUX dti-1426 59 22 inducted induct VERB dti-1426 59 23 by by ADP dti-1426 59 24 intramuscular intramuscular ADJ dti-1426 59 25 ( ( PUNCT dti-1426 59 26 i.m i.m PROPN dti-1426 59 27 . . PUNCT dti-1426 59 28 ) ) PUNCT dti-1426 60 1 administration administration NOUN dti-1426 60 2 of of ADP dti-1426 60 3 ketamine ketamine PROPN dti-1426 60 4 hydrochloride hydrochloride NOUN dti-1426 60 5 ( ( PUNCT dti-1426 60 6 25 25 NUM dti-1426 60 7     SPACE dti-1426 60 8 mg mg PROPN dti-1426 60 9 / / SYM dti-1426 60 10 kg kg PROPN dti-1426 60 11 of of ADP dti-1426 60 12 body body NOUN dti-1426 60 13 weight weight NOUN dti-1426 60 14 ) ) PUNCT dti-1426 60 15 and and CCONJ dti-1426 60 16 xylazine xylazine PROPN dti-1426 60 17 hydrochloride hydrochloride NOUN dti-1426 60 18 ( ( PUNCT dti-1426 60 19 15 15 NUM dti-1426 60 20     SPACE dti-1426 60 21 mg mg PROPN dti-1426 60 22 / / SYM dti-1426 60 23 kg kg PROPN dti-1426 60 24 ) ) PUNCT dti-1426 60 25 . . PUNCT dti-1426 61 1 after after ADP dti-1426 61 2 disappearance disappearance NOUN dti-1426 61 3 of of ADP dti-1426 61 4 the the DET dti-1426 61 5 pedal pedal ADJ dti-1426 61 6 reflex reflex NOUN dti-1426 61 7 in in ADP dti-1426 61 8 the the DET dti-1426 61 9 hindlimbs hindlimb NOUN dti-1426 61 10 , , PUNCT dti-1426 61 11 rabbits rabbit NOUN dti-1426 61 12 were be AUX dti-1426 61 13 placed place VERB dti-1426 61 14 on on ADP dti-1426 61 15 a a DET dti-1426 61 16 warming warm VERB dti-1426 61 17 operative operative ADJ dti-1426 61 18 platform platform NOUN dti-1426 61 19 ( ( PUNCT dti-1426 61 20 37 37 NUM dti-1426 61 21 ° ° NUM dti-1426 61 22 c c NOUN dti-1426 61 23 ) ) PUNCT dti-1426 61 24 in in ADP dti-1426 61 25 the the DET dti-1426 61 26 supine supine ADJ dti-1426 61 27 position position NOUN dti-1426 61 28 . . PUNCT dti-1426 62 1 a a DET dti-1426 62 2 23 23 NUM dti-1426 62 3 g g NOUN dti-1426 62 4 vascular vascular ADJ dti-1426 62 5 access access NOUN dti-1426 62 6 was be AUX dti-1426 62 7 obtained obtain VERB dti-1426 62 8 through through ADP dti-1426 62 9 the the DET dti-1426 62 10 marginal marginal ADJ dti-1426 62 11 vein vein NOUN dti-1426 62 12 of of ADP dti-1426 62 13 the the DET dti-1426 62 14 ear ear NOUN dti-1426 62 15 . . PUNCT dti-1426 63 1 the the DET dti-1426 63 2 skin skin NOUN dti-1426 63 3 of of ADP dti-1426 63 4 the the DET dti-1426 63 5 ventral ventral ADJ dti-1426 63 6 abdomen abdoman NOUN dti-1426 63 7 was be AUX dti-1426 63 8 aseptically aseptically ADV dti-1426 63 9 prepped preppe VERB dti-1426 63 10 with with ADP dti-1426 63 11 povidone povidone NOUN dti-1426 63 12 – – PUNCT dti-1426 63 13 iodine iodine NOUN dti-1426 63 14 solution solution NOUN dti-1426 63 15 . . PUNCT dti-1426 64 1 briefly briefly NOUN dti-1426 64 2 , , PUNCT dti-1426 64 3 a a DET dti-1426 64 4 midline midline NOUN dti-1426 64 5 laparotomy laparotomy NOUN dti-1426 64 6 incision incision NOUN dti-1426 64 7 was be AUX dti-1426 64 8 performed perform VERB dti-1426 64 9 and and CCONJ dti-1426 64 10 the the DET dti-1426 64 11 abdominal abdominal ADJ dti-1426 64 12 aorta aorta NOUN dti-1426 64 13 exposed expose VERB dti-1426 64 14 . . PUNCT dti-1426 65 1 renal renal ADJ dti-1426 65 2 arteries artery NOUN dti-1426 65 3 were be AUX dti-1426 65 4 identified identify VERB dti-1426 65 5 and and CCONJ dti-1426 65 6 following follow VERB dti-1426 65 7 administration administration NOUN dti-1426 65 8 of of ADP dti-1426 65 9 100 100 NUM dti-1426 65 10     SPACE dti-1426 65 11 iu iu NOUN dti-1426 65 12 / / SYM dti-1426 65 13 kg kg NOUN dti-1426 65 14 of of ADP dti-1426 65 15 sodium sodium NOUN dti-1426 65 16 heparin heparin NOUN dti-1426 65 17 , , PUNCT dti-1426 65 18 proximal proximal ADJ dti-1426 65 19 end end NOUN dti-1426 65 20 - - PUNCT dti-1426 65 21 to to ADP dti-1426 65 22 - - PUNCT dti-1426 65 23 side side NOUN dti-1426 65 24 anastomosis anastomosis NOUN dti-1426 65 25 with with ADP dti-1426 65 26 the the DET dti-1426 65 27 composite composite ADJ dti-1426 65 28 graft graft NOUN dti-1426 65 29 was be AUX dti-1426 65 30 constructed construct VERB dti-1426 65 31 using use VERB dti-1426 65 32 a a DET dti-1426 65 33 sidebiting sidebite VERB dti-1426 65 34 microclamp microclamp NOUN dti-1426 65 35     SPACE dti-1426 65 36 ~1 ~1 ADV dti-1426 65 37     SPACE dti-1426 65 38 cm cm NOUN dti-1426 65 39 below below ADP dti-1426 65 40 the the DET dti-1426 65 41 origin origin NOUN dti-1426 65 42 or or CCONJ dti-1426 65 43 renal renal ADJ dti-1426 65 44 arteries artery NOUN dti-1426 65 45 using use VERB dti-1426 65 46 monofilament monofilament NOUN dti-1426 65 47 8–0 8–0 NUM dti-1426 65 48 polypropylene polypropylene NOUN dti-1426 65 49 suture suture NOUN dti-1426 65 50 . . PUNCT dti-1426 66 1 aorta aorta NOUN dti-1426 66 2 was be AUX dti-1426 66 3 bypassed bypass VERB dti-1426 66 4 for for ADP dti-1426 66 5 a a DET dti-1426 66 6 tract tract NOUN dti-1426 66 7 of of ADP dti-1426 66 8 ~4 ~4 ADJ dti-1426 66 9     SPACE dti-1426 66 10 cm cm NOUN dti-1426 66 11 and and CCONJ dti-1426 66 12 the the DET dti-1426 66 13 distal distal ADJ dti-1426 66 14 end end NOUN dti-1426 66 15 graft graft NOUN dti-1426 66 16 was be AUX dti-1426 66 17 then then ADV dti-1426 66 18 end end NOUN dti-1426 66 19 - - PUNCT dti-1426 66 20 toside toside NOUN dti-1426 66 21 anastomosed anastomose VERB dti-1426 66 22 to to ADP dti-1426 66 23 aorta aorta NOUN dti-1426 66 24 before before ADP dti-1426 66 25 the the DET dti-1426 66 26 origin origin NOUN dti-1426 66 27 of of ADP dti-1426 66 28 iliac iliac NOUN dti-1426 66 29 arteries artery NOUN dti-1426 66 30 using use VERB dti-1426 66 31 monofilament monofilament NOUN dti-1426 66 32 8–0 8–0 NUM dti-1426 66 33 polypropylene polypropylene NOUN dti-1426 66 34 sutures suture NOUN dti-1426 66 35 . . PUNCT dti-1426 67 1 the the DET dti-1426 67 2 infrarenal infrarenal ADJ dti-1426 67 3 aorta aorta NOUN dti-1426 67 4 between between ADP dti-1426 67 5 the the DET dti-1426 67 6 two two NUM dti-1426 67 7 anastomoses anastomosis NOUN dti-1426 67 8 was be AUX dti-1426 67 9 ligated ligate VERB dti-1426 67 10 so so SCONJ dti-1426 67 11 that that SCONJ dti-1426 67 12 all all DET dti-1426 67 13 the the DET dti-1426 67 14 blood blood NOUN dti-1426 67 15 flow flow NOUN dti-1426 67 16 to to ADP dti-1426 67 17 the the DET dti-1426 67 18 inferior inferior ADJ dti-1426 67 19 limbs limb NOUN dti-1426 67 20 was be AUX dti-1426 67 21 dependent dependent ADJ dti-1426 67 22 on on ADP dti-1426 67 23 the the DET dti-1426 67 24 graft graft NOUN dti-1426 67 25 ( ( PUNCT dti-1426 67 26 fig fig NOUN dti-1426 67 27 . . PUNCT dti-1426 67 28     SPACE dti-1426 68 1 1 1 NUM dti-1426 68 2 ) ) PUNCT dti-1426 68 3 . . PUNCT dti-1426 69 1 muscle muscle NOUN dti-1426 69 2 layer layer NOUN dti-1426 69 3 and and CCONJ dti-1426 69 4 skin skin NOUN dti-1426 69 5 were be AUX dti-1426 69 6 closed close VERB dti-1426 69 7 with with ADP dti-1426 69 8 3–0 3–0 NUM dti-1426 69 9 polyglactin polyglactin NOUN dti-1426 69 10 absorbable absorbable NOUN dti-1426 69 11 suture suture NOUN dti-1426 69 12 ( ( PUNCT dti-1426 69 13 vycril vycril NOUN dti-1426 69 14 ; ; PUNCT dti-1426 69 15 ethicon ethicon NOUN dti-1426 69 16 ) ) PUNCT dti-1426 69 17 . . PUNCT dti-1426 70 1 after after ADP dti-1426 70 2 closure closure NOUN dti-1426 70 3 of of ADP dti-1426 70 4 the the DET dti-1426 70 5 abdomen abdomen NOUN dti-1426 70 6 , , PUNCT dti-1426 70 7 the the DET dti-1426 70 8 animals animal NOUN dti-1426 70 9 were be AUX dti-1426 70 10 allowed allow VERB dti-1426 70 11 to to PART dti-1426 70 12 recover recover VERB dti-1426 70 13 on on ADP dti-1426 70 14 a a DET dti-1426 70 15 warming warm VERB dti-1426 70 16 pad pad NOUN dti-1426 70 17 . . PUNCT dti-1426 71 1 the the DET dti-1426 71 2 surgical surgical ADJ dti-1426 71 3 procedure procedure NOUN dti-1426 71 4 was be AUX dti-1426 71 5 completed complete VERB dti-1426 71 6 within within ADP dti-1426 71 7 30 30 NUM dti-1426 71 8 minutes minute NOUN dti-1426 71 9 after after ADP dti-1426 71 10 the the DET dti-1426 71 11 initiation initiation NOUN dti-1426 71 12 of of ADP dti-1426 71 13 anesthesia anesthesia NOUN dti-1426 71 14 . . PUNCT dti-1426 72 1 when when SCONJ dti-1426 72 2 responsive responsive ADJ dti-1426 72 3 to to AUX dti-1426 72 4 stimuli stimulus NOUN dti-1426 72 5 and and CCONJ dti-1426 72 6 able able ADJ dti-1426 72 7 to to PART dti-1426 72 8 maintain maintain VERB dti-1426 72 9 an an DET dti-1426 72 10 upright upright ADJ dti-1426 72 11 posture posture NOUN dti-1426 72 12 , , PUNCT dti-1426 72 13 rabbits rabbit NOUN dti-1426 72 14 were be AUX dti-1426 72 15 returned return VERB dti-1426 72 16 to to ADP dti-1426 72 17 the the DET dti-1426 72 18 home home NOUN dti-1426 72 19 cage cage NOUN dti-1426 72 20 and and CCONJ dti-1426 72 21 analgesia analgesia NOUN dti-1426 72 22 initiated initiate VERB dti-1426 72 23 with with ADP dti-1426 72 24 buprenorphine buprenorphine NOUN dti-1426 72 25 ( ( PUNCT dti-1426 72 26 0.5 0.5 NUM dti-1426 72 27     SPACE dti-1426 72 28 mg mg PROPN dti-1426 72 29 / / SYM dti-1426 72 30 kg kg PROPN dti-1426 72 31 ) ) PUNCT dti-1426 72 32 and and CCONJ dti-1426 72 33 paracetamol paracetamol NOUN dti-1426 72 34 ( ( PUNCT dti-1426 72 35 1 1 NUM dti-1426 72 36     SPACE dti-1426 72 37 mg mg PROPN dti-1426 72 38 / / SYM dti-1426 72 39 kg kg PROPN dti-1426 72 40 ) ) PUNCT dti-1426 72 41 . . PUNCT dti-1426 73 1 the the DET dti-1426 73 2 first first ADJ dti-1426 73 3 three three NUM dti-1426 73 4 days day NOUN dti-1426 73 5 after after ADP dti-1426 73 6 surgery surgery NOUN dti-1426 73 7 , , PUNCT dti-1426 73 8 buprenorphine buprenorphine NOUN dti-1426 73 9 ( ( PUNCT dti-1426 73 10 0.5 0.5 NUM dti-1426 73 11     SPACE dti-1426 73 12 mg mg PROPN dti-1426 73 13 / / SYM dti-1426 73 14 kg kg PROPN dti-1426 73 15 b.i.d b.i.d PROPN dti-1426 73 16 . . PUNCT dti-1426 73 17 ) ) PUNCT dti-1426 74 1 and and CCONJ dti-1426 74 2 cefuroxime cefuroxime ADJ dti-1426 74 3 ( ( PUNCT dti-1426 74 4 100 100 NUM dti-1426 74 5     SPACE dti-1426 74 6 mg mg PROPN dti-1426 74 7 / / SYM dti-1426 74 8 kg kg PROPN dti-1426 74 9 b.i.d b.i.d PROPN dti-1426 74 10 . . PUNCT dti-1426 74 11 ) ) PUNCT dti-1426 74 12 were be AUX dti-1426 74 13 administered administer VERB dti-1426 74 14 subcutaneously subcutaneously ADV dti-1426 74 15 . . PUNCT dti-1426 75 1 the the DET dti-1426 75 2     SPACE dti-1426 75 3 animals animal NOUN dti-1426 75 4 received receive VERB dti-1426 75 5 no no DET dti-1426 75 6 antiaggregation antiaggregation NOUN dti-1426 75 7 therapy therapy NOUN dti-1426 75 8 . . PUNCT dti-1426 76 1 daily daily ADJ dti-1426 76 2 controls control NOUN dti-1426 76 3 using use VERB dti-1426 76 4 handheld handheld ADJ dti-1426 76 5 doppler doppler NOUN dti-1426 76 6 ultrasound ultrasound NOUN dti-1426 76 7 system system NOUN dti-1426 76 8 were be AUX dti-1426 76 9 performed perform VERB dti-1426 76 10 to to PART dti-1426 76 11 assess assess VERB dti-1426 76 12 patency patency NOUN dti-1426 76 13 of of ADP dti-1426 76 14 the the DET dti-1426 76 15 grafts graft NOUN dti-1426 76 16 and and CCONJ dti-1426 76 17 animals animal NOUN dti-1426 76 18 were be AUX dti-1426 76 19 examined examine VERB dti-1426 76 20 for for ADP dti-1426 76 21 signs sign NOUN dti-1426 76 22 of of ADP dti-1426 76 23 inferior inferior ADJ dti-1426 76 24 limbs limb NOUN dti-1426 76 25 weakness weakness NOUN dti-1426 76 26 or or CCONJ dti-1426 76 27 paralysis paralysis NOUN dti-1426 76 28 . . PUNCT dti-1426 77 1 four four NUM dti-1426 77 2 weeks week NOUN dti-1426 77 3 after after ADP dti-1426 77 4 implantation implantation NOUN dti-1426 77 5 , , PUNCT dti-1426 77 6 animals animal NOUN dti-1426 77 7 were be AUX dti-1426 77 8 humanely humanely ADV dti-1426 77 9 sacrificed sacrifice VERB dti-1426 77 10 and and CCONJ dti-1426 77 11 grafts graft NOUN dti-1426 77 12 were be AUX dti-1426 77 13 explanted explante VERB dti-1426 77 14 for for ADP dti-1426 77 15 evaluation evaluation NOUN dti-1426 77 16 . . PUNCT dti-1426 78 1 contrast contrast NOUN dti-1426 78 2 - - PUNCT dti-1426 78 3 enhanced enhance VERB dti-1426 78 4 vascular vascular ADJ dti-1426 78 5 imaging imaging NOUN dti-1426 78 6 . . PUNCT dti-1426 79 1 before before ADP dti-1426 79 2 sacrifice sacrifice NOUN dti-1426 79 3 , , PUNCT dti-1426 79 4 animals animal NOUN dti-1426 79 5 underwent undergo VERB dti-1426 79 6 ct ct NUM dti-1426 79 7 scanning scanning NOUN dti-1426 79 8 with with ADP dti-1426 79 9 intravenous intravenous ADJ dti-1426 79 10 contrast contrast NOUN dti-1426 79 11 agent agent NOUN dti-1426 79 12 . . PUNCT dti-1426 80 1 briefly briefly ADV dti-1426 80 2 , , PUNCT dti-1426 80 3 rabbits rabbit NOUN dti-1426 80 4 were be AUX dti-1426 80 5 anesthetized anesthetize VERB dti-1426 80 6 with with ADP dti-1426 80 7 midazolam midazolam PROPN dti-1426 80 8 at at ADP dti-1426 80 9 a a DET dti-1426 80 10 dose dose NOUN dti-1426 80 11 of of ADP dti-1426 80 12 2 2 NUM dti-1426 80 13     SPACE dti-1426 80 14 mg mg PROPN dti-1426 80 15 / / SYM dti-1426 80 16 kg kg PROPN dti-1426 80 17 i.m i.m PROPN dti-1426 80 18 . . PROPN dti-1426 81 1 iodinated iodinate VERB dti-1426 81 2 contrast contrast NOUN dti-1426 81 3 medium medium NOUN dti-1426 81 4 was be AUX dti-1426 81 5 injected inject VERB dti-1426 81 6 in in ADP dti-1426 81 7 the the DET dti-1426 81 8 marginal marginal ADJ dti-1426 81 9 ear ear NOUN dti-1426 81 10 vein vein VERB dti-1426 81 11 , , PUNCT dti-1426 81 12 and and CCONJ dti-1426 81 13 cardiac cardiac ADJ dti-1426 81 14 ct ct PROPN dti-1426 81 15 scans scan NOUN dti-1426 81 16 were be AUX dti-1426 81 17 obtained obtain VERB dti-1426 81 18 and and CCONJ dti-1426 81 19 reformatted reformatte VERB dti-1426 81 20 in in ADP dti-1426 81 21 3d 3d NOUN dti-1426 81 22 using use VERB dti-1426 81 23 maximum maximum ADJ dti-1426 81 24 intensity intensity NOUN dti-1426 81 25 projection projection NOUN dti-1426 81 26 ( ( PUNCT dti-1426 81 27 mip mip PROPN dti-1426 81 28 ) ) PUNCT dti-1426 81 29 and and CCONJ dti-1426 81 30 volume volume NOUN dti-1426 81 31 rendering rendering NOUN dti-1426 81 32 algorithms algorithm NOUN dti-1426 81 33 . . PUNCT dti-1426 82 1 histology histology NOUN dti-1426 82 2 . . PUNCT dti-1426 83 1 samples sample NOUN dti-1426 83 2 obtained obtain VERB dti-1426 83 3 were be AUX dti-1426 83 4 fixed fix VERB dti-1426 83 5 in in ADP dti-1426 83 6 4 4 NUM dti-1426 83 7 % % NOUN dti-1426 83 8 paraformaldehyde paraformaldehyde NOUN dti-1426 83 9 and and CCONJ dti-1426 83 10 embedded embed VERB dti-1426 83 11 in in ADP dti-1426 83 12 paraffin paraffin NOUN dti-1426 83 13 . . PUNCT dti-1426 84 1 serial serial ADJ dti-1426 84 2 sections section NOUN dti-1426 84 3 ( ( PUNCT dti-1426 84 4 6 6 NUM dti-1426 84 5     SPACE dti-1426 84 6 mm mm PROPN dti-1426 84 7 thick thick PROPN dti-1426 84 8 ) ) PUNCT dti-1426 84 9 were be AUX dti-1426 84 10 cut cut VERB dti-1426 84 11 and and CCONJ dti-1426 84 12 used use VERB dti-1426 84 13 for for ADP dti-1426 84 14 hematoxylin hematoxylin NOUN dti-1426 84 15 – – PUNCT dti-1426 84 16 eosin eosin NOUN dti-1426 84 17 staining stain VERB dti-1426 84 18 . . PUNCT dti-1426 85 1 results result NOUN dti-1426 85 2 at at ADP dti-1426 85 3 the the DET dti-1426 85 4 moment moment NOUN dti-1426 85 5 of of ADP dti-1426 85 6 surgery surgery NOUN dti-1426 85 7 , , PUNCT dti-1426 85 8 no no DET dti-1426 85 9 evidence evidence NOUN dti-1426 85 10 of of ADP dti-1426 85 11 transgraft transgraft NOUN dti-1426 85 12 leakage leakage NOUN dti-1426 85 13 of of ADP dti-1426 85 14 blood blood NOUN dti-1426 85 15 was be AUX dti-1426 85 16 demonstrated demonstrate VERB dti-1426 85 17 . . PUNCT dti-1426 86 1 during during ADP dti-1426 86 2 clinical clinical ADJ dti-1426 86 3 follow follow NOUN dti-1426 86 4 - - PUNCT dti-1426 86 5 up up NOUN dti-1426 86 6 , , PUNCT dti-1426 86 7 no no DET dti-1426 86 8 neurological neurological ADJ dti-1426 86 9 events event NOUN dti-1426 86 10 , , PUNCT dti-1426 86 11 infection infection NOUN dti-1426 86 12 , , PUNCT dti-1426 86 13 or or CCONJ dti-1426 86 14 other other ADJ dti-1426 86 15 surgical surgical ADJ dti-1426 86 16 complications complication NOUN dti-1426 86 17 have have AUX dti-1426 86 18 been be AUX dti-1426 86 19 noted note VERB dti-1426 86 20 . . PUNCT dti-1426 87 1 use use NOUN dti-1426 87 2 of of ADP dti-1426 87 3 sidebiting sidebite VERB dti-1426 87 4 clamp clamp NOUN dti-1426 87 5 and and CCONJ dti-1426 87 6 the the DET dti-1426 87 7 endto endto NOUN dti-1426 87 8 - - PUNCT dti-1426 87 9 side side NOUN dti-1426 87 10 fashion fashion NOUN dti-1426 87 11 of of ADP dti-1426 87 12 the the DET dti-1426 87 13 anastomosis anastomosis NOUN dti-1426 87 14 used use VERB dti-1426 87 15 prevented prevent VERB dti-1426 87 16 the the DET dti-1426 87 17 known known ADJ dti-1426 87 18 tendency tendency NOUN dti-1426 87 19 to to ADP dti-1426 87 20 paraplegia paraplegia PROPN dti-1426 87 21 resulting result VERB dti-1426 87 22 from from ADP dti-1426 87 23 cross cross ADJ dti-1426 87 24 - - ADJ dti-1426 87 25 clamping clamping NOUN dti-1426 87 26 of of ADP dti-1426 87 27 infrarenal infrarenal ADJ dti-1426 87 28 aorta aorta NOUN dti-1426 87 29 . . PUNCT dti-1426 88 1 all all DET dti-1426 88 2 the the DET dti-1426 88 3 grafts graft NOUN dti-1426 88 4 and and CCONJ dti-1426 88 5 iliac iliac NOUN dti-1426 88 6 axes axis NOUN dti-1426 88 7 were be AUX dti-1426 88 8 patent patent NOUN dti-1426 88 9 at at ADP dti-1426 88 10 four four NUM dti-1426 88 11 weeks week NOUN dti-1426 88 12 postimplant postimplant ADJ dti-1426 88 13 and and CCONJ dti-1426 88 14 perfusion perfusion NOUN dti-1426 88 15 preserved preserve VERB dti-1426 88 16 in in ADP dti-1426 88 17 the the DET dti-1426 88 18 inferior inferior ADJ dti-1426 88 19 limbs limb NOUN dti-1426 88 20 . . PUNCT dti-1426 89 1 kidneys kidney NOUN dti-1426 89 2 were be AUX dti-1426 89 3 adequately adequately ADV dti-1426 89 4 perfused perfuse VERB dti-1426 89 5 ( ( PUNCT dti-1426 89 6 fig fig NOUN dti-1426 89 7 . . PUNCT dti-1426 89 8 2 2 NUM dti-1426 89 9 ) ) PUNCT dti-1426 89 10 . . PUNCT dti-1426 90 1 at at ADP dti-1426 90 2 explant explant NOUN dti-1426 90 3 the the DET dti-1426 90 4 graft graft NOUN dti-1426 90 5 preserved preserve VERB dti-1426 90 6 their their PRON dti-1426 90 7 integrity integrity NOUN dti-1426 90 8 with with ADP dti-1426 90 9 no no DET dti-1426 90 10 signs sign NOUN dti-1426 90 11 of of ADP dti-1426 90 12 significant significant ADJ dti-1426 90 13 intraluminal intraluminal ADJ dti-1426 90 14 thrombosis thrombosis NOUN dti-1426 90 15 or or CCONJ dti-1426 90 16 exuberant exuberant ADJ dti-1426 90 17 foreign foreign ADJ dti-1426 90 18 - - PUNCT dti-1426 90 19 body body NOUN dti-1426 90 20 inflammatory inflammatory ADJ dti-1426 90 21 reaction reaction NOUN dti-1426 90 22 . . PUNCT dti-1426 91 1 at at ADP dti-1426 91 2 histology histology NOUN dti-1426 91 3 scaffolds scaffold NOUN dti-1426 91 4 appeared appear VERB dti-1426 91 5 uniformly uniformly ADV dti-1426 91 6 cellularized cellularize VERB dti-1426 91 7 with with ADP dti-1426 91 8 a a DET dti-1426 91 9 variety variety NOUN dti-1426 91 10 elements element NOUN dti-1426 91 11 colonizing colonize VERB dti-1426 91 12 the the DET dti-1426 91 13 scaffold scaffold NOUN dti-1426 91 14 fibrillar fibrillar ADJ dti-1426 91 15 framework framework NOUN dti-1426 91 16 . . PUNCT dti-1426 92 1 polymer polymer NOUN dti-1426 92 2 fibers fiber NOUN dti-1426 92 3     SPACE dti-1426 92 4 could could AUX dti-1426 92 5 be be AUX dti-1426 92 6 seen see VERB dti-1426 92 7 with with ADP dti-1426 92 8 cells cell NOUN dti-1426 92 9 engrafted engraft VERB dti-1426 92 10 within within ADP dti-1426 92 11 scaffold scaffold NOUN dti-1426 92 12 meshes mesh NOUN dti-1426 92 13 with with ADP dti-1426 92 14 deposition deposition NOUN dti-1426 92 15 of of ADP dti-1426 92 16 ecm ecm NOUN dti-1426 92 17 . . PUNCT dti-1426 93 1 interestingly interestingly ADV dti-1426 93 2 , , PUNCT dti-1426 93 3 the the DET dti-1426 93 4 inner inner ADJ dti-1426 93 5 surface surface NOUN dti-1426 93 6 was be AUX dti-1426 93 7 populated populate VERB dti-1426 93 8 by by ADP dti-1426 93 9 elongated elongate VERB dti-1426 93 10 cells cell NOUN dti-1426 93 11 with with ADP dti-1426 93 12 rare rare ADJ dti-1426 93 13 cytoplasm cytoplasm NOUN dti-1426 93 14 , , PUNCT dti-1426 93 15 a a DET dti-1426 93 16 high high ADJ dti-1426 93 17 figure figure NOUN dti-1426 93 18 1 1 NUM dti-1426 93 19 . . PUNCT dti-1426 94 1 ( ( PUNCT dti-1426 94 2 a a X dti-1426 94 3 ) ) PUNCT dti-1426 94 4 schematic schematic ADJ dti-1426 94 5 diagram diagram NOUN dti-1426 94 6 of of ADP dti-1426 94 7 the the DET dti-1426 94 8 experimental experimental ADJ dti-1426 94 9 procedure procedure NOUN dti-1426 94 10 . . PUNCT dti-1426 95 1 ( ( PUNCT dti-1426 95 2 b b X dti-1426 95 3 ) ) PUNCT dti-1426 95 4 intraoperative intraoperative ADJ dti-1426 95 5 photograph photograph NOUN dti-1426 95 6 showing show VERB dti-1426 95 7 the the DET dti-1426 95 8 plla plla NOUN dti-1426 95 9 armored armor VERB dti-1426 95 10 scaffold scaffold NOUN dti-1426 95 11 implanted implant VERB dti-1426 95 12 and and CCONJ dti-1426 95 13 the the DET dti-1426 95 14 ligature ligature NOUN dti-1426 95 15 of of ADP dti-1426 95 16 the the DET dti-1426 95 17 segment segment NOUN dti-1426 95 18 of of ADP dti-1426 95 19 infrarenal infrarenal ADJ dti-1426 95 20 aorta aorta NOUN dti-1426 95 21 between between ADP dti-1426 95 22 the the DET dti-1426 95 23 two two NUM dti-1426 95 24 anastomoses anastomosis NOUN dti-1426 95 25 . . PUNCT dti-1426 96 1 http://www.la-press.com http://www.la-press.com X dti-1426 96 2 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1426 96 3 spadaccio spadaccio PROPN dti-1426 96 4 et et PROPN dti-1426 96 5 al al PROPN dti-1426 96 6 4 4 NUM dti-1426 96 7 drug drug NOUN dti-1426 96 8 target target NOUN dti-1426 96 9 insights insight NOUN dti-1426 96 10 2016:10(s1 2016:10(s1 NUM dti-1426 96 11 ) ) PUNCT dti-1426 96 12 nucleus nucleus NOUN dti-1426 96 13 / / SYM dti-1426 96 14 cytoplasm cytoplasm NOUN dti-1426 96 15 ratio ratio NOUN dti-1426 96 16 , , PUNCT dti-1426 96 17 and and CCONJ dti-1426 96 18 nuclei nucleus NOUN dti-1426 96 19 protruding protrude VERB dti-1426 96 20 in in ADP dti-1426 96 21 the the DET dti-1426 96 22 lumen luman NOUN dti-1426 96 23 . . PUNCT dti-1426 97 1 this this DET dti-1426 97 2     SPACE dti-1426 97 3 endothelial endothelial NOUN dti-1426 97 4 - - PUNCT dti-1426 97 5 like like ADJ dti-1426 97 6 morphology morphology NOUN dti-1426 97 7 was be AUX dti-1426 97 8 not not PART dti-1426 97 9 encountered encounter VERB dti-1426 97 10 within within ADP dti-1426 97 11 the the DET dti-1426 97 12 wall wall NOUN dti-1426 97 13 of of ADP dti-1426 97 14 the the DET dti-1426 97 15 scaffold scaffold NOUN dti-1426 97 16 , , PUNCT dti-1426 97 17 in in ADP dti-1426 97 18 which which PRON dti-1426 97 19 cellular cellular ADJ dti-1426 97 20 elements element NOUN dti-1426 97 21 looked look VERB dti-1426 97 22 more more ADV dti-1426 97 23 irregular irregular ADJ dti-1426 97 24 and and CCONJ dti-1426 97 25 immersed immerse VERB dti-1426 97 26 in in ADP dti-1426 97 27 an an DET dti-1426 97 28 eosinophil eosinophil ADJ dti-1426 97 29 connectival connectival ADJ dti-1426 97 30 atmosphere atmosphere NOUN dti-1426 97 31 . . PUNCT dti-1426 98 1 the the DET dti-1426 98 2 outer outer ADJ dti-1426 98 3 side side NOUN dti-1426 98 4 of of ADP dti-1426 98 5 the the DET dti-1426 98 6 tubular tubular ADJ dti-1426 98 7 graft graft NOUN dti-1426 98 8 was be AUX dti-1426 98 9 populated populate VERB dti-1426 98 10 by by ADP dti-1426 98 11 spindle spindle NOUN dti-1426 98 12 - - PUNCT dti-1426 98 13 shaped shape VERB dti-1426 98 14 cells cell NOUN dti-1426 98 15 with with ADP dti-1426 98 16 characters character NOUN dti-1426 98 17 resembling resemble VERB dti-1426 98 18 proliferating proliferate VERB dti-1426 98 19 fibroblasts fibroblast NOUN dti-1426 98 20 ( ( PUNCT dti-1426 98 21 fig fig NOUN dti-1426 98 22 . . PUNCT dti-1426 98 23     SPACE dti-1426 98 24 3 3 NUM dti-1426 98 25 ) ) PUNCT dti-1426 98 26 . . PUNCT dti-1426 99 1 taken take VERB dti-1426 99 2 together together ADV dti-1426 99 3 , , PUNCT dti-1426 99 4 these these DET dti-1426 99 5 findings finding NOUN dti-1426 99 6 might might AUX dti-1426 99 7 reliably reliably ADV dti-1426 99 8 suggest suggest VERB dti-1426 99 9 the the DET dti-1426 99 10 idea idea NOUN dti-1426 99 11 of of ADP dti-1426 99 12 self self NOUN dti-1426 99 13 - - PUNCT dti-1426 99 14 colonization colonization NOUN dti-1426 99 15 of of ADP dti-1426 99 16 the the DET dti-1426 99 17 scaffold scaffold NOUN dti-1426 99 18 by by ADP dti-1426 99 19 endogenous endogenous ADJ dti-1426 99 20 cells cell NOUN dti-1426 99 21 that that PRON dti-1426 99 22 progressively progressively ADV dti-1426 99 23 acquired acquire VERB dti-1426 99 24 different different ADJ dti-1426 99 25 phenotypes phenotype NOUN dti-1426 99 26 within within ADP dti-1426 99 27 the the DET dti-1426 99 28 scaffold scaffold NOUN dti-1426 99 29 . . PUNCT dti-1426 100 1 figure figure NOUN dti-1426 100 2 2 2 NUM dti-1426 100 3 . . NUM dti-1426 100 4 computed compute VERB dti-1426 100 5 tomographic tomographic ADJ dti-1426 100 6 angiography angiography NOUN dti-1426 100 7 study study NOUN dti-1426 100 8 . . PUNCT dti-1426 101 1 left leave VERB dti-1426 101 2 : : PUNCT dti-1426 101 3 contrast contrast NOUN dti-1426 101 4 - - PUNCT dti-1426 101 5 enhanced enhance VERB dti-1426 101 6 imaging imaging NOUN dti-1426 101 7 . . PUNCT dti-1426 102 1 note note VERB dti-1426 102 2 patency patency NOUN dti-1426 102 3 of of ADP dti-1426 102 4 the the DET dti-1426 102 5 tegv tegv NOUN dti-1426 102 6 . . PUNCT dti-1426 103 1 right right ADJ dti-1426 103 2 : : PUNCT dti-1426 103 3 3d 3d NUM dti-1426 103 4 reconstruction reconstruction NOUN dti-1426 103 5 with with ADP dti-1426 103 6 mip mip PROPN dti-1426 103 7 and and CCONJ dti-1426 103 8 volume volume NOUN dti-1426 103 9 rendering rendering NOUN dti-1426 103 10 algorithms algorithm NOUN dti-1426 103 11 . . PUNCT dti-1426 104 1 figure figure VERB dti-1426 104 2 3 3 NUM dti-1426 104 3 . . PUNCT dti-1426 105 1 histological histological ADJ dti-1426 105 2 analysis analysis NOUN dti-1426 105 3 . . PUNCT dti-1426 106 1 hematoxylin hematoxylin NOUN dti-1426 106 2 – – PUNCT dti-1426 106 3 eosin eosin NOUN dti-1426 106 4 staining stain VERB dti-1426 106 5 . . PUNCT dti-1426 107 1 the the DET dti-1426 107 2 scaffold scaffold NOUN dti-1426 107 3 appeared appear VERB dti-1426 107 4 to to PART dti-1426 107 5 be be AUX dti-1426 107 6 densely densely ADV dti-1426 107 7 colonized colonize VERB dti-1426 107 8 by by ADP dti-1426 107 9 different different ADJ dti-1426 107 10 cellular cellular ADJ dti-1426 107 11 elements element NOUN dti-1426 107 12 that that PRON dti-1426 107 13 progressively progressively ADV dti-1426 107 14 acquired acquire VERB dti-1426 107 15 different different ADJ dti-1426 107 16 phenotypic phenotypic ADJ dti-1426 107 17 characteristics characteristic NOUN dti-1426 107 18 according accord VERB dti-1426 107 19 to to ADP dti-1426 107 20 the the DET dti-1426 107 21 region region NOUN dti-1426 107 22 of of ADP dti-1426 107 23 the the DET dti-1426 107 24 tevg tevg PROPN dti-1426 107 25 in in ADP dti-1426 107 26 which which PRON dti-1426 107 27 they they PRON dti-1426 107 28 engrafted engraft VERB dti-1426 107 29 . . PUNCT dti-1426 108 1 ( ( PUNCT dti-1426 108 2 a a X dti-1426 108 3 ) ) PUNCT dti-1426 108 4 5× 5× NOUN dti-1426 108 5 magnification magnification NOUN dti-1426 108 6 . . PUNCT dti-1426 109 1 ( ( PUNCT dti-1426 109 2 b b X dti-1426 109 3 ) ) PUNCT dti-1426 109 4 10× 10× NOUN dti-1426 109 5 magnification magnification NOUN dti-1426 109 6 . . PUNCT dti-1426 110 1 ( ( PUNCT dti-1426 110 2 c c X dti-1426 110 3 ) ) PUNCT dti-1426 110 4 40× 40× NUM dti-1426 110 5 magnification magnification NOUN dti-1426 110 6 of of ADP dti-1426 110 7 the the DET dti-1426 110 8 inner inner ADJ dti-1426 110 9 side side NOUN dti-1426 110 10 of of ADP dti-1426 110 11 the the DET dti-1426 110 12 tevg tevg PROPN dti-1426 110 13 . . PUNCT dti-1426 111 1 note note VERB dti-1426 111 2 flat flat ADJ dti-1426 111 3 elongated elongate VERB dti-1426 111 4 cells cell NOUN dti-1426 111 5 with with ADP dti-1426 111 6 nucleus nucleus NOUN dti-1426 111 7 protruding protrude VERB dti-1426 111 8 in in ADP dti-1426 111 9 the the DET dti-1426 111 10 lumen luman NOUN dti-1426 111 11 ( ( PUNCT dti-1426 111 12 arrow arrow NOUN dti-1426 111 13 ) ) PUNCT dti-1426 111 14 organized organize VERB dti-1426 111 15 in in ADP dti-1426 111 16 an an DET dti-1426 111 17 endothelial endothelial NOUN dti-1426 111 18 - - PUNCT dti-1426 111 19 like like ADJ dti-1426 111 20 fashion fashion NOUN dti-1426 111 21 . . PUNCT dti-1426 112 1 ( ( PUNCT dti-1426 112 2 d d X dti-1426 112 3 ) ) PUNCT dti-1426 112 4 40× 40× NUM dti-1426 112 5 magnification magnification NOUN dti-1426 112 6 of of ADP dti-1426 112 7 the the DET dti-1426 112 8 outer outer ADJ dti-1426 112 9 side side NOUN dti-1426 112 10 of of ADP dti-1426 112 11 the the DET dti-1426 112 12 tevg tevg PROPN dti-1426 112 13 . . PUNCT dti-1426 113 1 note note VERB dti-1426 113 2 spindle spindle NOUN dti-1426 113 3 - - PUNCT dti-1426 113 4 shaped shape VERB dti-1426 113 5 cells cell NOUN dti-1426 113 6 reliably reliably ADV dti-1426 113 7 representing represent VERB dti-1426 113 8 fibroblasts fibroblast NOUN dti-1426 113 9 ( ( PUNCT dti-1426 113 10 arrow arrow NOUN dti-1426 113 11 ) ) PUNCT dti-1426 113 12 . . PUNCT dti-1426 114 1 f f PROPN dti-1426 114 2 indicates indicate VERB dti-1426 114 3 fibers fiber NOUN dti-1426 114 4 of of ADP dti-1426 114 5 polymer polymer NOUN dti-1426 114 6 in in ADP dti-1426 114 7 both both PRON dti-1426 114 8 cross cross ADJ dti-1426 114 9 and and CCONJ dti-1426 114 10 long long ADJ dti-1426 114 11 axis axis NOUN dti-1426 114 12 section section NOUN dti-1426 114 13 . . PUNCT dti-1426 115 1 http://www.la-press.com http://www.la-press.com X dti-1426 116 1 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 VERB dti-1426 116 2 hybrid hybrid ADJ dti-1426 116 3 armored armored ADJ dti-1426 116 4 vascular vascular ADJ dti-1426 116 5 graft graft NOUN dti-1426 116 6 manufacturing manufacturing NOUN dti-1426 116 7 techniques technique NOUN dti-1426 116 8 5drug 5drug NUM dti-1426 116 9 target target NOUN dti-1426 116 10 insights insight NOUN dti-1426 116 11 2016:10(s1 2016:10(s1 NUM dti-1426 116 12 ) ) PUNCT dti-1426 116 13 discussion discussion NOUN dti-1426 116 14 the the DET dti-1426 116 15 two two NUM dti-1426 116 16 major major ADJ dti-1426 116 17 concerns concern NOUN dti-1426 116 18 in in ADP dti-1426 116 19 tevgs tevg NOUN dti-1426 116 20 rely rely VERB dti-1426 116 21 on on ADP dti-1426 116 22 the the DET dti-1426 116 23 prevention prevention NOUN dti-1426 116 24 of of ADP dti-1426 116 25 thrombosis thrombosis NOUN dti-1426 116 26 and and CCONJ dti-1426 116 27 mechanical mechanical ADJ dti-1426 116 28 resistance resistance NOUN dti-1426 116 29 of of ADP dti-1426 116 30 the the DET dti-1426 116 31 construct construct NOUN dti-1426 116 32 when when SCONJ dti-1426 116 33 implanted implant VERB dti-1426 116 34 in in ADP dti-1426 116 35 vivo vivo NOUN dti-1426 116 36 . . PUNCT dti-1426 117 1 acute acute ADJ dti-1426 117 2 graft graft NOUN dti-1426 117 3 failure failure NOUN dti-1426 117 4 for for ADP dti-1426 117 5 thrombotic thrombotic ADJ dti-1426 117 6 occlusion occlusion NOUN dti-1426 117 7 or or CCONJ dti-1426 117 8 structural structural ADJ dti-1426 117 9 deterioration deterioration NOUN dti-1426 117 10 with with ADP dti-1426 117 11 aneurysmal aneurysmal ADJ dti-1426 117 12 degeneration degeneration NOUN dti-1426 117 13 or or CCONJ dti-1426 117 14 rupture rupture NOUN dti-1426 117 15 are be AUX dti-1426 117 16 considered consider VERB dti-1426 117 17 the the DET dti-1426 117 18 main main ADJ dti-1426 117 19 drawbacks drawback NOUN dti-1426 117 20 of of ADP dti-1426 117 21 tevg tevg PROPN dti-1426 117 22 harnessing harness VERB dti-1426 117 23 their their PRON dti-1426 117 24 actual actual ADJ dti-1426 117 25 clinical clinical ADJ dti-1426 117 26 application.26–28 application.26–28 NOUN dti-1426 117 27 in in ADP dti-1426 117 28 this this DET dti-1426 117 29 proofof proofof ADJ dti-1426 117 30 - - PUNCT dti-1426 117 31 principle principle NOUN dti-1426 117 32 study study NOUN dti-1426 117 33 , , PUNCT dti-1426 117 34 a a DET dti-1426 117 35 pcl pcl NOUN dti-1426 117 36 - - PUNCT dti-1426 117 37 armored armor VERB dti-1426 117 38 heparin heparin NOUN dti-1426 117 39 - - PUNCT dti-1426 117 40 releasing release VERB dti-1426 117 41 plla plla NOUN dti-1426 117 42 graft graft NOUN dti-1426 117 43 showed show VERB dti-1426 117 44 good good ADJ dti-1426 117 45 patency patency NOUN dti-1426 117 46 rate rate NOUN dti-1426 117 47 and and CCONJ dti-1426 117 48 structural structural ADJ dti-1426 117 49 integrity integrity NOUN dti-1426 117 50 in in ADP dti-1426 117 51 a a DET dti-1426 117 52 previously previously ADV dti-1426 117 53 described describe VERB dti-1426 117 54 model model NOUN dti-1426 117 55 of of ADP dti-1426 117 56 aortoaortic aortoaortic ADJ dti-1426 117 57 bypass.24 bypass.24 NOUN dti-1426 117 58 we we PRON dti-1426 117 59 avoided avoid VERB dti-1426 117 60 an an DET dti-1426 117 61 aortic aortic ADJ dti-1426 117 62 interposition interposition NOUN dti-1426 117 63 graft graft NOUN dti-1426 117 64 model model NOUN dti-1426 117 65 for for ADP dti-1426 117 66 a a DET dti-1426 117 67 number number NOUN dti-1426 117 68 of of ADP dti-1426 117 69 reasons reason NOUN dti-1426 117 70 . . PUNCT dti-1426 118 1 first first ADV dti-1426 118 2 , , PUNCT dti-1426 118 3 to to PART dti-1426 118 4 avoid avoid VERB dti-1426 118 5 the the DET dti-1426 118 6 well well ADV dti-1426 118 7 - - PUNCT dti-1426 118 8 known know VERB dti-1426 118 9 tendency tendency NOUN dti-1426 118 10 to to ADP dti-1426 118 11 paraplegia paraplegia VERB dti-1426 118 12 after after SCONJ dti-1426 118 13 infrarenal infrarenal ADJ dti-1426 118 14 aortic aortic ADJ dti-1426 118 15 cross cross NOUN dti-1426 118 16 - - NOUN dti-1426 118 17 clamp clamp ADJ dti-1426 118 18 in in ADP dti-1426 118 19 rabbits.29,30 rabbits.29,30 NOUN dti-1426 118 20 second second ADJ dti-1426 118 21 , , PUNCT dti-1426 118 22 to to PART dti-1426 118 23 simulate simulate VERB dti-1426 118 24 the the DET dti-1426 118 25 clinical clinical ADJ dti-1426 118 26 scenario scenario NOUN dti-1426 118 27 normally normally ADV dti-1426 118 28 characterized characterize VERB dti-1426 118 29 by by ADP dti-1426 118 30 end end NOUN dti-1426 118 31 - - PUNCT dti-1426 118 32 to to ADP dti-1426 118 33 - - PUNCT dti-1426 118 34 side side NOUN dti-1426 118 35 anastomoses anastomosis NOUN dti-1426 118 36 rather rather ADV dti-1426 118 37 than than ADP dti-1426 118 38 end end VERB dti-1426 118 39 - - PUNCT dti-1426 118 40 to to ADP dti-1426 118 41 - - PUNCT dti-1426 118 42 end end NOUN dti-1426 118 43 sutured suture VERB dti-1426 118 44 grafts graft NOUN dti-1426 118 45 . . PUNCT dti-1426 119 1 third third ADJ dti-1426 119 2 , , PUNCT dti-1426 119 3 to to PART dti-1426 119 4 test test VERB dti-1426 119 5 the the DET dti-1426 119 6 antithrombogenic antithrombogenic ADJ dti-1426 119 7 properties property NOUN dti-1426 119 8 of of ADP dti-1426 119 9 the the DET dti-1426 119 10 tevg tevg PROPN dti-1426 119 11 in in ADP dti-1426 119 12 a a DET dti-1426 119 13 condition condition NOUN dti-1426 119 14 characterized characterize VERB dti-1426 119 15 by by ADP dti-1426 119 16 a a DET dti-1426 119 17 higher high ADJ dti-1426 119 18 risk risk NOUN dti-1426 119 19 of of ADP dti-1426 119 20 turbulence turbulence NOUN dti-1426 119 21 and and CCONJ dti-1426 119 22 hemodynamic hemodynamic ADJ dti-1426 119 23 irregularity irregularity NOUN dti-1426 119 24 , , PUNCT dti-1426 119 25 as as ADP dti-1426 119 26 for for ADP dti-1426 119 27 a a DET dti-1426 119 28 90 90 NUM dti-1426 119 29 ° ° NUM dti-1426 119 30 anastomosis anastomosis NOUN dti-1426 119 31 , , PUNCT dti-1426 119 32 rather rather ADV dti-1426 119 33 than than ADP dti-1426 119 34 a a DET dti-1426 119 35 full full ADJ dti-1426 119 36 - - PUNCT dti-1426 119 37 channel channel NOUN dti-1426 119 38 straight straight ADJ dti-1426 119 39 anastomosis anastomosis NOUN dti-1426 119 40 between between ADP dti-1426 119 41 conduits conduit NOUN dti-1426 119 42 of of ADP dti-1426 119 43 similar similar ADJ dti-1426 119 44 diameters diameter NOUN dti-1426 119 45 . . PUNCT dti-1426 120 1 the the DET dti-1426 120 2 tevg tevg PROPN dti-1426 120 3 remained remain VERB dti-1426 120 4 patent patent NOUN dti-1426 120 5 throughout throughout ADP dti-1426 120 6 the the DET dti-1426 120 7 duration duration NOUN dti-1426 120 8 of of ADP dti-1426 120 9 the the DET dti-1426 120 10 study study NOUN dti-1426 120 11 and and CCONJ dti-1426 120 12 no no DET dti-1426 120 13 signs sign NOUN dti-1426 120 14 of of ADP dti-1426 120 15 embolic embolic ADJ dti-1426 120 16 or or CCONJ dti-1426 120 17 neurological neurological ADJ dti-1426 120 18 events event NOUN dti-1426 120 19 were be AUX dti-1426 120 20 noted note VERB dti-1426 120 21 . . PUNCT dti-1426 121 1 the the DET dti-1426 121 2 latter latter ADJ dti-1426 121 3 acquires acquire VERB dti-1426 121 4 a a DET dti-1426 121 5 significant significant ADJ dti-1426 121 6 value value NOUN dti-1426 121 7 considering consider VERB dti-1426 121 8 that that SCONJ dti-1426 121 9 , , PUNCT dti-1426 121 10 for for ADP dti-1426 121 11 the the DET dti-1426 121 12 characteristics characteristic NOUN dti-1426 121 13 of of ADP dti-1426 121 14 the the DET dti-1426 121 15 model model NOUN dti-1426 121 16 used use VERB dti-1426 121 17 , , PUNCT dti-1426 121 18 the the DET dti-1426 121 19 entire entire ADJ dti-1426 121 20 limbs limb NOUN dti-1426 121 21 perfusion perfusion NOUN dti-1426 121 22 was be AUX dti-1426 121 23 dependent dependent ADJ dti-1426 121 24 on on ADP dti-1426 121 25 the the DET dti-1426 121 26 graft graft NOUN dti-1426 121 27 and and CCONJ dti-1426 121 28 no no DET dti-1426 121 29 antiplatelet antiplatelet NOUN dti-1426 121 30 agents agent NOUN dti-1426 121 31 were be AUX dti-1426 121 32 given give VERB dti-1426 121 33 as as ADP dti-1426 121 34 thrombosis thrombosis NOUN dti-1426 121 35 prophylaxis prophylaxis NOUN dti-1426 121 36 . . PUNCT dti-1426 122 1 the the DET dti-1426 122 2 scaffold scaffold NOUN dti-1426 122 3 appeared appear VERB dti-1426 122 4 to to PART dti-1426 122 5 be be AUX dti-1426 122 6 densely densely ADV dti-1426 122 7 colonized colonize VERB dti-1426 122 8 by by ADP dti-1426 122 9 different different ADJ dti-1426 122 10 cellular cellular ADJ dti-1426 122 11 elements element NOUN dti-1426 122 12 that that PRON dti-1426 122 13 progressively progressively ADV dti-1426 122 14 acquired acquire VERB dti-1426 122 15 different different ADJ dti-1426 122 16 phenotypic phenotypic ADJ dti-1426 122 17 characteristics characteristic NOUN dti-1426 122 18 according accord VERB dti-1426 122 19 to to ADP dti-1426 122 20 the the DET dti-1426 122 21 region region NOUN dti-1426 122 22 of of ADP dti-1426 122 23 the the DET dti-1426 122 24 tevg tevg PROPN dti-1426 122 25 in in ADP dti-1426 122 26 which which PRON dti-1426 122 27 they they PRON dti-1426 122 28 engrafted engraft VERB dti-1426 122 29 . . PUNCT dti-1426 123 1 the the DET dti-1426 123 2 inner inner ADJ dti-1426 123 3 side side NOUN dti-1426 123 4 was be AUX dti-1426 123 5 populated populate VERB dti-1426 123 6 by by ADP dti-1426 123 7 elongated elongate VERB dti-1426 123 8 flat flat ADJ dti-1426 123 9 cells cell NOUN dti-1426 123 10 organized organize VERB dti-1426 123 11 in in ADP dti-1426 123 12 an an DET dti-1426 123 13 endothelial endothelial NOUN dti-1426 123 14 - - PUNCT dti-1426 123 15 like like ADJ dti-1426 123 16 fashion fashion NOUN dti-1426 123 17 . . PUNCT dti-1426 124 1 cells cell NOUN dti-1426 124 2 within within ADP dti-1426 124 3 the the DET dti-1426 124 4 scaffold scaffold NOUN dti-1426 124 5 wall wall NOUN dti-1426 124 6 and and CCONJ dti-1426 124 7 in in ADP dti-1426 124 8 the the DET dti-1426 124 9 outer outer ADJ dti-1426 124 10 side side NOUN dti-1426 124 11 showed show VERB dti-1426 124 12 characters character NOUN dti-1426 124 13 of of ADP dti-1426 124 14 both both CCONJ dti-1426 124 15 quiescent quiescent ADJ dti-1426 124 16 and and CCONJ dti-1426 124 17 active active ADJ dti-1426 124 18 fibroblast fibroblast NOUN dti-1426 124 19 , , PUNCT dti-1426 124 20 indicating indicate VERB dti-1426 124 21 the the DET dti-1426 124 22 contemporaneous contemporaneous ADJ dti-1426 124 23 presence presence NOUN dti-1426 124 24 of of ADP dti-1426 124 25 different different ADJ dti-1426 124 26 degrees degree NOUN dti-1426 124 27 of of ADP dti-1426 124 28 cell cell NOUN dti-1426 124 29 activity activity NOUN dti-1426 124 30 in in ADP dti-1426 124 31 terms term NOUN dti-1426 124 32 of of ADP dti-1426 124 33 neo neo NOUN dti-1426 124 34 - - NOUN dti-1426 124 35 ecm ecm NOUN dti-1426 124 36 deposition deposition NOUN dti-1426 124 37 . . PUNCT dti-1426 125 1 the the DET dti-1426 125 2 outer outer ADJ dti-1426 125 3 layers layer NOUN dti-1426 125 4 of of ADP dti-1426 125 5 the the DET dti-1426 125 6 scaffolds scaffold NOUN dti-1426 125 7 were be AUX dti-1426 125 8 colonized colonize VERB dti-1426 125 9 by by ADP dti-1426 125 10 spindleshaped spindleshape VERB dti-1426 125 11 cells cell NOUN dti-1426 125 12 , , PUNCT dti-1426 125 13 which which PRON dti-1426 125 14 might might AUX dti-1426 125 15 either either CCONJ dti-1426 125 16 represent represent VERB dti-1426 125 17 fibroblasts fibroblast NOUN dti-1426 125 18 or or CCONJ dti-1426 125 19 smooth smooth ADJ dti-1426 125 20 muscle muscle NOUN dti-1426 125 21 cells cell NOUN dti-1426 125 22 . . PUNCT dti-1426 126 1 as as SCONJ dti-1426 126 2 shown show VERB dti-1426 126 3 in in ADP dti-1426 126 4 our our PRON dti-1426 126 5 previous previous ADJ dti-1426 126 6 work work NOUN dti-1426 126 7 , , PUNCT dti-1426 126 8 heparin heparin ADJ dti-1426 126 9 functionalization functionalization NOUN dti-1426 126 10 exerted exert VERB dti-1426 126 11 a a DET dti-1426 126 12 significant significant ADJ dti-1426 126 13 influence influence NOUN dti-1426 126 14 on on ADP dti-1426 126 15 cell cell NOUN dti-1426 126 16 differentiation differentiation NOUN dti-1426 126 17 toward toward ADP dti-1426 126 18 vascular vascular ADJ dti-1426 126 19 endothelium.13 endothelium.13 NOUN dti-1426 126 20 besides besides SCONJ dti-1426 126 21 the the DET dti-1426 126 22 well well ADV dti-1426 126 23 - - PUNCT dti-1426 126 24 known know VERB dti-1426 126 25 action action NOUN dti-1426 126 26 on on ADP dti-1426 126 27 thrombosis thrombosis NOUN dti-1426 126 28 prevention,31,32 prevention,31,32 X dti-1426 126 29 heparin heparin NOUN dti-1426 126 30 is be AUX dti-1426 126 31 essential essential ADJ dti-1426 126 32 for for ADP dti-1426 126 33 endothelial endothelial ADJ dti-1426 126 34 cell cell NOUN dti-1426 126 35 adhesion adhesion NOUN dti-1426 126 36 and and CCONJ dti-1426 126 37 homeostasis homeostasis NOUN dti-1426 126 38 , , PUNCT dti-1426 126 39 ameliorates ameliorate VERB dti-1426 126 40 cell cell NOUN dti-1426 126 41 engraftment engraftment NOUN dti-1426 126 42 into into ADP dti-1426 126 43 the the DET dti-1426 126 44 scaffold scaffold NOUN dti-1426 126 45 , , PUNCT dti-1426 126 46 and and CCONJ dti-1426 126 47 provides provide VERB dti-1426 126 48 signals signal NOUN dti-1426 126 49 for for ADP dti-1426 126 50 cells cell NOUN dti-1426 126 51 survival survival NOUN dti-1426 126 52 and and CCONJ dti-1426 126 53 differentiation.33,34 differentiation.33,34 NOUN dti-1426 126 54 additionally additionally ADV dti-1426 126 55 , , PUNCT dti-1426 126 56 heparin heparin ADJ dti-1426 126 57 binds bind VERB dti-1426 126 58 a a DET dti-1426 126 59 number number NOUN dti-1426 126 60 of of ADP dti-1426 126 61 angiogenic angiogenic ADJ dti-1426 126 62 growth growth NOUN dti-1426 126 63 factors factor NOUN dti-1426 126 64 , , PUNCT dti-1426 126 65 such such ADJ dti-1426 126 66 as as ADP dti-1426 126 67 vascular vascular ADJ dti-1426 126 68 endothelial endothelial ADJ dti-1426 126 69 growth growth NOUN dti-1426 126 70 factor factor NOUN dti-1426 126 71 ( ( PUNCT dti-1426 126 72 vegf vegf PROPN dti-1426 126 73 ) ) PUNCT dti-1426 126 74 and and CCONJ dti-1426 126 75 basic basic ADJ dti-1426 126 76 fibroblast fibroblast ADJ dti-1426 126 77 growth growth NOUN dti-1426 126 78 factor factor NOUN dti-1426 126 79 ( ( PUNCT dti-1426 126 80 bfgf).33 bfgf).33 PROPN dti-1426 126 81 therefore therefore ADV dti-1426 126 82 , , PUNCT dti-1426 126 83 scaffold scaffold NOUN dti-1426 126 84 functionalization functionalization NOUN dti-1426 126 85 with with ADP dti-1426 126 86 heparin heparin NOUN dti-1426 126 87 would would AUX dti-1426 126 88 permit permit VERB dti-1426 126 89 to to PART dti-1426 126 90 attract attract VERB dti-1426 126 91 and and CCONJ dti-1426 126 92 concentrate concentrate VERB dti-1426 126 93 in in ADP dti-1426 126 94 the the DET dti-1426 126 95 scaffold scaffold NOUN dti-1426 126 96 the the DET dti-1426 126 97 soluble soluble ADJ dti-1426 126 98 angiogenic angiogenic ADJ dti-1426 126 99 growth growth NOUN dti-1426 126 100 factors factor NOUN dti-1426 126 101 released release VERB dti-1426 126 102 in in ADP dti-1426 126 103 the the DET dti-1426 126 104 blood blood NOUN dti-1426 126 105 stream stream NOUN dti-1426 126 106 during during ADP dti-1426 126 107 a a DET dti-1426 126 108 vascular vascular ADJ dti-1426 126 109 injury injury NOUN dti-1426 126 110 . . PUNCT dti-1426 127 1 this this PRON dti-1426 127 2 might might AUX dti-1426 127 3 reliably reliably ADV dti-1426 127 4 explain explain VERB dti-1426 127 5 the the DET dti-1426 127 6 flourishing flourish VERB dti-1426 127 7 cell cell NOUN dti-1426 127 8 colonization colonization NOUN dti-1426 127 9 within within ADP dti-1426 127 10 the the DET dti-1426 127 11 scaffold scaffold NOUN dti-1426 127 12 after after ADP dti-1426 127 13 four four NUM dti-1426 127 14 weeks week NOUN dti-1426 127 15 and and CCONJ dti-1426 127 16 their their PRON dti-1426 127 17 differentiation differentiation NOUN dti-1426 127 18 toward toward ADP dti-1426 127 19 an an DET dti-1426 127 20 endothelial endothelial NOUN dti-1426 127 21 - - PUNCT dti-1426 127 22 like like ADJ dti-1426 127 23 phenotype phenotype NOUN dti-1426 127 24 . . PUNCT dti-1426 128 1 however however ADV dti-1426 128 2 , , PUNCT dti-1426 128 3 specific specific ADJ dti-1426 128 4 immunophenotype immunophenotype NOUN dti-1426 128 5 analysis analysis NOUN dti-1426 128 6 of of ADP dti-1426 128 7 both both CCONJ dti-1426 128 8 resident resident NOUN dti-1426 128 9 and and CCONJ dti-1426 128 10 blood blood NOUN dti-1426 128 11 stream stream NOUN dti-1426 128 12 cells cell NOUN dti-1426 128 13 should should AUX dti-1426 128 14 be be AUX dti-1426 128 15 performed perform VERB dti-1426 128 16 to to PART dti-1426 128 17 support support VERB dti-1426 128 18 this this DET dti-1426 128 19 hypothesis hypothesis NOUN dti-1426 128 20 . . PUNCT dti-1426 129 1 conversely conversely ADV dti-1426 129 2 , , PUNCT dti-1426 129 3 the the DET dti-1426 129 4 fibroblastic fibroblastic ADJ dti-1426 129 5 / / SYM dti-1426 129 6 smooth smooth ADJ dti-1426 129 7 muscle muscle NOUN dti-1426 129 8 cell cell NOUN dti-1426 129 9 phenotype phenotype NOUN dti-1426 129 10 observed observe VERB dti-1426 129 11 in in ADP dti-1426 129 12 the the DET dti-1426 129 13 outer outer ADJ dti-1426 129 14 side side NOUN dti-1426 129 15 of of ADP dti-1426 129 16 the the DET dti-1426 129 17 scaffold scaffold NOUN dti-1426 129 18 might might AUX dti-1426 129 19 represent represent VERB dti-1426 129 20 either either CCONJ dti-1426 129 21 a a DET dti-1426 129 22 further further ADJ dti-1426 129 23 evolution evolution NOUN dti-1426 129 24 of of ADP dti-1426 129 25 the the DET dti-1426 129 26 same same ADJ dti-1426 129 27 population population NOUN dti-1426 129 28 of of ADP dti-1426 129 29 cells cell NOUN dti-1426 129 30 colonizing colonize VERB dti-1426 129 31 the the DET dti-1426 129 32 scaffold scaffold NOUN dti-1426 129 33 from from ADP dti-1426 129 34 the the DET dti-1426 129 35 blood blood NOUN dti-1426 129 36 stream stream NOUN dti-1426 129 37 or or CCONJ dti-1426 129 38 the the DET dti-1426 129 39 results result NOUN dti-1426 129 40 of of ADP dti-1426 129 41 a a DET dti-1426 129 42 foreign foreign ADJ dti-1426 129 43 body body NOUN dti-1426 129 44 reaction reaction NOUN dti-1426 129 45 from from ADP dti-1426 129 46 the the DET dti-1426 129 47 tissue tissue NOUN dti-1426 129 48 surrounding surround VERB dti-1426 129 49 the the DET dti-1426 129 50 graft graft NOUN dti-1426 129 51 . . PUNCT dti-1426 130 1 in in ADP dti-1426 130 2 the the DET dti-1426 130 3 first first ADJ dti-1426 130 4 case case NOUN dti-1426 130 5 , , PUNCT dti-1426 130 6 we we PRON dti-1426 130 7 might might AUX dti-1426 130 8 reliably reliably ADV dti-1426 130 9 speculate speculate VERB dti-1426 130 10 that that SCONJ dti-1426 130 11 both both CCONJ dti-1426 130 12 biological biological ADJ dti-1426 130 13 and and CCONJ dti-1426 130 14 mechanical mechanical ADJ dti-1426 130 15 factors factor NOUN dti-1426 130 16 ( ( PUNCT dti-1426 130 17 ie ie X dti-1426 130 18 , , PUNCT dti-1426 130 19 shear shear NOUN dti-1426 130 20 stress stress NOUN dti-1426 130 21 at at ADP dti-1426 130 22 luminal luminal ADJ dti-1426 130 23 side side NOUN dti-1426 130 24 ) ) PUNCT dti-1426 130 25 have have AUX dti-1426 130 26 influenced influence VERB dti-1426 130 27 the the DET dti-1426 130 28 differentiation differentiation NOUN dti-1426 130 29 of of ADP dti-1426 130 30 the the DET dti-1426 130 31 cells cell NOUN dti-1426 130 32 . . PUNCT dti-1426 131 1 however however ADV dti-1426 131 2 , , PUNCT dti-1426 131 3 in in ADP dti-1426 131 4 the the DET dti-1426 131 5 in in ADP dti-1426 131 6 vivo vivo ADJ dti-1426 131 7 hemodynamic hemodynamic ADJ dti-1426 131 8 conditions condition NOUN dti-1426 131 9 , , PUNCT dti-1426 131 10 several several ADJ dti-1426 131 11 other other ADJ dti-1426 131 12 factors factor NOUN dti-1426 131 13 might might AUX dti-1426 131 14 be be AUX dti-1426 131 15 involved involve VERB dti-1426 131 16 in in ADP dti-1426 131 17 these these DET dti-1426 131 18 phenomena phenomenon NOUN dti-1426 131 19 and and CCONJ dti-1426 131 20 exert exert VERB dti-1426 131 21 specific specific ADJ dti-1426 131 22 effects effect NOUN dti-1426 131 23 on on ADP dti-1426 131 24 the the DET dti-1426 131 25 system system NOUN dti-1426 131 26 . . PUNCT dti-1426 132 1 in in ADP dti-1426 132 2 the the DET dti-1426 132 3 second second ADJ dti-1426 132 4 case case NOUN dti-1426 132 5 , , PUNCT dti-1426 132 6 despite despite SCONJ dti-1426 132 7 plla plla NOUN dti-1426 132 8 is be AUX dti-1426 132 9 known know VERB dti-1426 132 10 to to PART dti-1426 132 11 be be AUX dti-1426 132 12 highly highly ADV dti-1426 132 13 biocompatible biocompatible ADJ dti-1426 132 14 and and CCONJ dti-1426 132 15 to to PART dti-1426 132 16 not not PART dti-1426 132 17 elicit elicit VERB dti-1426 132 18 strong strong ADJ dti-1426 132 19 inflammatory inflammatory ADJ dti-1426 132 20 reactions reaction NOUN dti-1426 132 21 , , PUNCT dti-1426 132 22 the the DET dti-1426 132 23 connective connective ADJ dti-1426 132 24 tissue tissue NOUN dti-1426 132 25 surrounding surround VERB dti-1426 132 26 the the DET dti-1426 132 27 tevg tevg PROPN dti-1426 132 28 might might AUX dti-1426 132 29 have have AUX dti-1426 132 30 constituted constitute VERB dti-1426 132 31 a a DET dti-1426 132 32 fibroblastic fibroblastic ADJ dti-1426 132 33 layer layer NOUN dti-1426 132 34 around around ADP dti-1426 132 35 the the DET dti-1426 132 36 prosthesis prosthesis NOUN dti-1426 132 37 . . PUNCT dti-1426 133 1 clearly clearly ADV dti-1426 133 2 , , PUNCT dti-1426 133 3 further further ADJ dti-1426 133 4 studies study NOUN dti-1426 133 5 are be AUX dti-1426 133 6 required require VERB dti-1426 133 7 to to PART dti-1426 133 8 elucidate elucidate VERB dti-1426 133 9 the the DET dti-1426 133 10 mechanism mechanism NOUN dti-1426 133 11 underlying underlie VERB dti-1426 133 12 these these DET dti-1426 133 13 findings finding NOUN dti-1426 133 14 . . PUNCT dti-1426 134 1 different different ADJ dti-1426 134 2 from from ADP dti-1426 134 3 other other ADJ dti-1426 134 4 approaches approach NOUN dti-1426 134 5 and and CCONJ dti-1426 134 6 in in ADP dti-1426 134 7 light light NOUN dti-1426 134 8 of of ADP dti-1426 134 9 a a DET dti-1426 134 10 translational translational ADJ dti-1426 134 11 inspiration inspiration NOUN dti-1426 134 12 , , PUNCT dti-1426 134 13 in in ADP dti-1426 134 14 this this DET dti-1426 134 15 study study NOUN dti-1426 134 16 , , PUNCT dti-1426 134 17 we we PRON dti-1426 134 18 did do AUX dti-1426 134 19 not not PART dti-1426 134 20 preseed preseed VERB dti-1426 134 21 scaffolds scaffold NOUN dti-1426 134 22 with with ADP dti-1426 134 23 autologous autologous ADJ dti-1426 134 24 cells cell NOUN dti-1426 134 25 . . PUNCT dti-1426 135 1 indeed indeed ADV dti-1426 135 2 , , PUNCT dti-1426 135 3 in in ADP dti-1426 135 4 order order NOUN dti-1426 135 5 to to PART dti-1426 135 6 overcome overcome VERB dti-1426 135 7 many many ADJ dti-1426 135 8 of of ADP dti-1426 135 9 the the DET dti-1426 135 10 biological biological ADJ dti-1426 135 11 , , PUNCT dti-1426 135 12 economical economical ADJ dti-1426 135 13 , , PUNCT dti-1426 135 14 logistic logistic ADJ dti-1426 135 15 , , PUNCT dti-1426 135 16 and and CCONJ dti-1426 135 17 ethical ethical ADJ dti-1426 135 18 concerns concern NOUN dti-1426 135 19 , , PUNCT dti-1426 135 20 which which PRON dti-1426 135 21 are be AUX dti-1426 135 22 currently currently ADV dti-1426 135 23 known know VERB dti-1426 135 24 to to PART dti-1426 135 25 hurdle hurdle VERB dti-1426 135 26 the the DET dti-1426 135 27 clinical clinical ADJ dti-1426 135 28 application application NOUN dti-1426 135 29 of of ADP dti-1426 135 30 cellular cellular NOUN dti-1426 135 31 - - PUNCT dti-1426 135 32 based base VERB dti-1426 135 33 therapy therapy NOUN dti-1426 135 34 , , PUNCT dti-1426 135 35 we we PRON dti-1426 135 36 decided decide VERB dti-1426 135 37 to to PART dti-1426 135 38 explore explore VERB dti-1426 135 39 a a DET dti-1426 135 40 strategy strategy NOUN dti-1426 135 41 that that PRON dti-1426 135 42 avoids avoid VERB dti-1426 135 43 the the DET dti-1426 135 44 use use NOUN dti-1426 135 45 of of ADP dti-1426 135 46 cells cell NOUN dti-1426 135 47 but but CCONJ dti-1426 135 48 mostly mostly ADV dti-1426 135 49 relies rely VERB dti-1426 135 50 on on ADP dti-1426 135 51 the the DET dti-1426 135 52 biomimetic biomimetic ADJ dti-1426 135 53 design design NOUN dti-1426 135 54 of of ADP dti-1426 135 55 the the DET dti-1426 135 56 scaffold scaffold NOUN dti-1426 135 57 and and CCONJ dti-1426 135 58 its its PRON dti-1426 135 59 paracrine paracrine ADJ dti-1426 135 60 effect effect NOUN dti-1426 135 61 as as ADP dti-1426 135 62 a a DET dti-1426 135 63 drug drug NOUN dti-1426 135 64 - - PUNCT dti-1426 135 65 eluting elute VERB dti-1426 135 66 device device NOUN dti-1426 135 67 and and CCONJ dti-1426 135 68 might might AUX dti-1426 135 69 , , PUNCT dti-1426 135 70 therefore therefore ADV dti-1426 135 71 , , PUNCT dti-1426 135 72 be be AUX dti-1426 135 73 more more ADV dti-1426 135 74 rapidly rapidly ADV dti-1426 135 75 translatable translatable ADJ dti-1426 135 76 to to ADP dti-1426 135 77 the the DET dti-1426 135 78 clinical clinical ADJ dti-1426 135 79 practice practice NOUN dti-1426 135 80 . . PUNCT dti-1426 136 1 the the DET dti-1426 136 2 rationale rationale NOUN dti-1426 136 3 underlying underlie VERB dti-1426 136 4 this this DET dti-1426 136 5 study study NOUN dti-1426 136 6 concerned concern VERB dti-1426 136 7 the the DET dti-1426 136 8 possibility possibility NOUN dti-1426 136 9 to to PART dti-1426 136 10 exploit exploit VERB dti-1426 136 11 the the DET dti-1426 136 12 endogenous endogenous ADJ dti-1426 136 13 reparative reparative ADJ dti-1426 136 14 capabilities capability NOUN dti-1426 136 15 of of ADP dti-1426 136 16 the the DET dti-1426 136 17 body body NOUN dti-1426 136 18 and and CCONJ dti-1426 136 19 to to PART dti-1426 136 20 guide guide VERB dti-1426 136 21 these these DET dti-1426 136 22 regenerative regenerative ADJ dti-1426 136 23 resources resource NOUN dti-1426 136 24 toward toward ADP dti-1426 136 25 tissue tissue NOUN dti-1426 136 26 restoration restoration NOUN dti-1426 136 27 by by ADP dti-1426 136 28 means mean NOUN dti-1426 136 29 of of ADP dti-1426 136 30 a a DET dti-1426 136 31 tailored tailor VERB dti-1426 136 32 absorbable absorbable ADJ dti-1426 136 33 material material NOUN dti-1426 136 34 . . PUNCT dti-1426 137 1 circulating circulate VERB dti-1426 137 2 endothelial endothelial ADJ dti-1426 137 3 progenitor progenitor NOUN dti-1426 137 4 cells cell NOUN dti-1426 137 5 or or CCONJ dti-1426 137 6 bone bone NOUN dti-1426 137 7 marrow marrow NOUN dti-1426 137 8 - - PUNCT dti-1426 137 9 derived derive VERB dti-1426 137 10 cells cell NOUN dti-1426 137 11 recruited recruit VERB dti-1426 137 12 from from ADP dti-1426 137 13 the the DET dti-1426 137 14 blood blood NOUN dti-1426 137 15 stream stream NOUN dti-1426 137 16 might might AUX dti-1426 137 17 therefore therefore ADV dti-1426 137 18 colonize colonize VERB dti-1426 137 19 an an DET dti-1426 137 20 artificial artificial ADJ dti-1426 137 21 matrix matrix NOUN dti-1426 137 22 that that PRON dti-1426 137 23 , , PUNCT dti-1426 137 24 for for ADP dti-1426 137 25 its its PRON dti-1426 137 26 internal internal ADJ dti-1426 137 27 structure structure NOUN dti-1426 137 28 , , PUNCT dti-1426 137 29 closely closely ADV dti-1426 137 30 simulates simulate VERB dti-1426 137 31 the the DET dti-1426 137 32 native native ADJ dti-1426 137 33 ecm ecm PROPN dti-1426 137 34 atmosphere atmosphere NOUN dti-1426 137 35 and and CCONJ dti-1426 137 36 actively actively ADV dti-1426 137 37 emanates emanate VERB dti-1426 137 38 biological biological ADJ dti-1426 137 39 signals signal NOUN dti-1426 137 40 to to PART dti-1426 137 41 support support VERB dti-1426 137 42 their their PRON dti-1426 137 43 survival survival NOUN dti-1426 137 44 and and CCONJ dti-1426 137 45 differentiation differentiation NOUN dti-1426 137 46 . . PUNCT dti-1426 138 1 recruited recruit VERB dti-1426 138 2 cells cell NOUN dti-1426 138 3 would would AUX dti-1426 138 4 in in ADP dti-1426 138 5 fact fact NOUN dti-1426 138 6 differentiate differentiate VERB dti-1426 138 7 within within ADP dti-1426 138 8 a a DET dti-1426 138 9 3d 3d NUM dti-1426 138 10 environment environment NOUN dti-1426 138 11 that that PRON dti-1426 138 12 closely closely ADV dti-1426 138 13 mimics mimic VERB dti-1426 138 14 the the DET dti-1426 138 15 organization organization NOUN dti-1426 138 16 of of ADP dti-1426 138 17 the the DET dti-1426 138 18 vascular vascular ADJ dti-1426 138 19 ecm ecm NOUN dti-1426 138 20 and and CCONJ dti-1426 138 21 guarantees guarantee VERB dti-1426 138 22 progressive progressive ADJ dti-1426 138 23 cell cell NOUN dti-1426 138 24 growth growth NOUN dti-1426 138 25 and and CCONJ dti-1426 138 26 neotissue neotissue NOUN dti-1426 138 27 formation formation NOUN dti-1426 138 28 . . PUNCT dti-1426 139 1 the the DET dti-1426 139 2 concept concept NOUN dti-1426 139 3 of of ADP dti-1426 139 4 fabricating fabricate VERB dti-1426 139 5 a a DET dti-1426 139 6 scaffold scaffold NOUN dti-1426 139 7 recapitulating recapitulate VERB dti-1426 139 8 native native ADJ dti-1426 139 9 ecm ecm NOUN dti-1426 139 10 and and CCONJ dti-1426 139 11 delivering deliver VERB dti-1426 139 12 molecules molecule NOUN dti-1426 139 13 like like ADP dti-1426 139 14 heparin heparin NOUN dti-1426 139 15 , , PUNCT dti-1426 139 16 which which PRON dti-1426 139 17 are be AUX dti-1426 139 18 able able ADJ dti-1426 139 19 to to PART dti-1426 139 20 stimulate stimulate VERB dti-1426 139 21 stem stem NOUN dti-1426 139 22 cells cell NOUN dti-1426 139 23 differentiation differentiation NOUN dti-1426 139 24 and and CCONJ dti-1426 139 25 also also ADV dti-1426 139 26 to to PART dti-1426 139 27 produce produce VERB dti-1426 139 28 crucial crucial ADJ dti-1426 139 29 systemic systemic ADJ dti-1426 139 30 effects effect NOUN dti-1426 139 31 , , PUNCT dti-1426 139 32 has have AUX dti-1426 139 33 been be AUX dti-1426 139 34 previously previously ADV dti-1426 139 35 explored explore VERB dti-1426 139 36 and and CCONJ dti-1426 139 37 validated validate VERB dti-1426 139 38 by by ADP dti-1426 139 39 our our PRON dti-1426 139 40 group group NOUN dti-1426 139 41 also also ADV dti-1426 139 42 in in ADP dti-1426 139 43 nonvascular nonvascular ADJ dti-1426 139 44 fields.35–38 fields.35–38 NOUN dti-1426 139 45 in in ADP dti-1426 139 46 this this DET dti-1426 139 47 study study NOUN dti-1426 139 48 , , PUNCT dti-1426 139 49 we we PRON dti-1426 139 50 aimed aim VERB dti-1426 139 51 at at ADP dti-1426 139 52 developing develop VERB dti-1426 139 53 a a DET dti-1426 139 54 device device NOUN dti-1426 139 55 able able ADJ dti-1426 139 56 to to PART dti-1426 139 57 boost boost VERB dti-1426 139 58 the the DET dti-1426 139 59 endogenous endogenous ADJ dti-1426 139 60 process process NOUN dti-1426 139 61 of of ADP dti-1426 139 62 reendothelialization reendothelialization NOUN dti-1426 139 63 and and CCONJ dti-1426 139 64 , , PUNCT dti-1426 139 65 contemporaneously contemporaneously ADV dti-1426 139 66 , , PUNCT dti-1426 139 67 to to PART dti-1426 139 68 simplify simplify VERB dti-1426 139 69 and and CCONJ dti-1426 139 70 improve improve VERB dti-1426 139 71 the the DET dti-1426 139 72 pharmacological pharmacological NOUN dti-1426 139 73 handling handling NOUN dti-1426 139 74 and and CCONJ dti-1426 139 75 the the DET dti-1426 139 76 outcomes outcome NOUN dti-1426 139 77 of of ADP dti-1426 139 78 the the DET dti-1426 139 79 graft graft NOUN dti-1426 139 80 once once ADV dti-1426 139 81 in in ADP dti-1426 139 82 the the DET dti-1426 139 83 clinical clinical ADJ dti-1426 139 84 scenario scenario NOUN dti-1426 139 85 . . PUNCT dti-1426 140 1 the the DET dti-1426 140 2 idea idea NOUN dti-1426 140 3 of of ADP dti-1426 140 4 combining combine VERB dti-1426 140 5 biomaterials biomaterial NOUN dti-1426 140 6 with with ADP dti-1426 140 7 different different ADJ dti-1426 140 8 resorption resorption NOUN dti-1426 140 9 timings timing NOUN dti-1426 140 10 to to PART dti-1426 140 11 progressively progressively ADV dti-1426 140 12 accompany accompany VERB dti-1426 140 13 vascular vascular ADJ dti-1426 140 14 reconstitution reconstitution NOUN dti-1426 140 15 over over ADP dti-1426 140 16 time time NOUN dti-1426 140 17 is be AUX dti-1426 140 18 also also ADV dti-1426 140 19 novel novel ADJ dti-1426 140 20 . . PUNCT dti-1426 141 1 additionally additionally ADV dti-1426 141 2 , , PUNCT dti-1426 141 3 the the DET dti-1426 141 4 proposed propose VERB dti-1426 141 5 manufacturing manufacturing NOUN dti-1426 141 6 technique technique NOUN dti-1426 141 7 is be AUX dti-1426 141 8 amenable amenable ADJ dti-1426 141 9 to to PART dti-1426 141 10 be be AUX dti-1426 141 11 used use VERB dti-1426 141 12 in in ADP dti-1426 141 13 the the DET dti-1426 141 14 context context NOUN dti-1426 141 15 of of ADP dti-1426 141 16 gmp gmp PROPN dti-1426 141 17 facilities facility NOUN dti-1426 141 18 in in ADP dti-1426 141 19 view view NOUN dti-1426 141 20 of of ADP dti-1426 141 21 a a DET dti-1426 141 22 potential potential ADJ dti-1426 141 23 translational translational ADJ dti-1426 141 24 application application NOUN dti-1426 141 25 . . PUNCT dti-1426 142 1 in in ADP dti-1426 142 2 conclusion conclusion NOUN dti-1426 142 3 , , PUNCT dti-1426 142 4 this this DET dti-1426 142 5 preliminary preliminary ADJ dti-1426 142 6 study study NOUN dti-1426 142 7 assessed assess VERB dti-1426 142 8 the the DET dti-1426 142 9 feasibility feasibility NOUN dti-1426 142 10 and and CCONJ dti-1426 142 11 the the DET dti-1426 142 12 in in ADP dti-1426 142 13 vivo vivo ADJ dti-1426 142 14 effectiveness effectiveness NOUN dti-1426 142 15 of of ADP dti-1426 142 16 a a DET dti-1426 142 17 heparin heparin NOUN dti-1426 142 18 - - PUNCT dti-1426 142 19 releasing releasing NOUN dti-1426 142 20 armored armored ADJ dti-1426 142 21 tubular tubular ADJ dti-1426 142 22 scaffold scaffold NOUN dti-1426 142 23 . . PUNCT dti-1426 143 1 scaffold scaffold NOUN dti-1426 143 2 has have AUX dti-1426 143 3 been be AUX dti-1426 143 4 adequately adequately ADV dti-1426 143 5 populated populate VERB dti-1426 143 6 by by ADP dti-1426 143 7 endogenous endogenous ADJ dti-1426 143 8 cells cell NOUN dti-1426 143 9 and and CCONJ dti-1426 143 10 did do AUX dti-1426 143 11 not not PART dti-1426 143 12 show show VERB dti-1426 143 13 signs sign NOUN dti-1426 143 14 of of ADP dti-1426 143 15 http://www.la-press.com http://www.la-press.com X dti-1426 143 16 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1426 143 17 spadaccio spadaccio PROPN dti-1426 143 18 et et PROPN dti-1426 143 19 al al PROPN dti-1426 143 20 6 6 NUM dti-1426 143 21 drug drug NOUN dti-1426 143 22 target target NOUN dti-1426 143 23 insights insight NOUN dti-1426 143 24 2016:10(s1 2016:10(s1 NUM dti-1426 143 25 ) ) PUNCT dti-1426 143 26 thrombosis thrombosis NOUN dti-1426 143 27 or or CCONJ dti-1426 143 28 structural structural ADJ dti-1426 143 29 failure failure NOUN dti-1426 143 30 with with ADP dti-1426 143 31 no no DET dti-1426 143 32 need need NOUN dti-1426 143 33 of of ADP dti-1426 143 34 antiplatelet antiplatelet NOUN dti-1426 143 35 therapy therapy NOUN dti-1426 143 36 . . PUNCT dti-1426 144 1 if if SCONJ dti-1426 144 2 confirmed confirm VERB dti-1426 144 3 by by ADP dti-1426 144 4 larger large ADJ dti-1426 144 5 studies study NOUN dti-1426 144 6 , , PUNCT dti-1426 144 7 we we PRON dti-1426 144 8 might might AUX dti-1426 144 9 reliably reliably ADV dti-1426 144 10 speculate speculate VERB dti-1426 144 11 that that SCONJ dti-1426 144 12 this this DET dti-1426 144 13 construct construct NOUN dti-1426 144 14 could could AUX dti-1426 144 15 constitute constitute VERB dti-1426 144 16 an an DET dti-1426 144 17 attractive attractive ADJ dti-1426 144 18 alternative alternative NOUN dti-1426 144 19 in in ADP dti-1426 144 20 the the DET dti-1426 144 21 panorama panorama NOUN dti-1426 144 22 of of ADP dti-1426 144 23 tissue tissue NOUN dti-1426 144 24 engineering engineering NOUN dti-1426 144 25 of of ADP dti-1426 144 26 vascular vascular ADJ dti-1426 144 27 grafts graft NOUN dti-1426 144 28 overcoming overcome VERB dti-1426 144 29 the the DET dti-1426 144 30 majority majority NOUN dti-1426 144 31 of of ADP dti-1426 144 32 the the DET dti-1426 144 33 limits limit NOUN dti-1426 144 34 currently currently ADV dti-1426 144 35 known know VERB dti-1426 144 36 for for ADP dti-1426 144 37 tevg tevg PROPN dti-1426 144 38 and and CCONJ dti-1426 144 39 allowing allow VERB dti-1426 144 40 for for ADP dti-1426 144 41 a a DET dti-1426 144 42 potentially potentially ADV dti-1426 144 43 easier easy ADJ dti-1426 144 44 clinical clinical ADJ dti-1426 144 45 management management NOUN dti-1426 144 46 . . PUNCT dti-1426 145 1 limitations limitation NOUN dti-1426 145 2 among among ADP dti-1426 145 3 the the DET dti-1426 145 4 limitations limitation NOUN dti-1426 145 5 of of ADP dti-1426 145 6 this this DET dti-1426 145 7 study study NOUN dti-1426 145 8 , , PUNCT dti-1426 145 9 the the DET dti-1426 145 10 authors author NOUN dti-1426 145 11 acknowledge acknowledge VERB dti-1426 145 12 the the DET dti-1426 145 13 lack lack NOUN dti-1426 145 14 of of ADP dti-1426 145 15 an an DET dti-1426 145 16 immunohistological immunohistological ADJ dti-1426 145 17 analysis analysis NOUN dti-1426 145 18 of of ADP dti-1426 145 19 the the DET dti-1426 145 20 cells cell NOUN dti-1426 145 21 colonizing colonize VERB dti-1426 145 22 the the DET dti-1426 145 23 scaffolds scaffold NOUN dti-1426 145 24 to to PART dti-1426 145 25 demonstrate demonstrate VERB dti-1426 145 26 the the DET dti-1426 145 27 phenomena phenomenon NOUN dti-1426 145 28 of of ADP dti-1426 145 29 endothelialization endothelialization NOUN dti-1426 145 30 and and CCONJ dti-1426 145 31 smooth smooth ADJ dti-1426 145 32 muscular muscular ADJ dti-1426 145 33 differentiation differentiation NOUN dti-1426 145 34 speculated speculate VERB dti-1426 145 35 in in ADP dti-1426 145 36 the the DET dti-1426 145 37 text text NOUN dti-1426 145 38 . . PUNCT dti-1426 146 1 the the DET dti-1426 146 2 scarcity scarcity NOUN dti-1426 146 3 of of ADP dti-1426 146 4 a a DET dti-1426 146 5 specific specific ADJ dti-1426 146 6 antibody antibody NOUN dti-1426 146 7 to to PART dti-1426 146 8 detect detect VERB dti-1426 146 9 rabbit rabbit NOUN dti-1426 146 10 markers marker NOUN dti-1426 146 11 limited limit VERB dti-1426 146 12 this this DET dti-1426 146 13 study study NOUN dti-1426 146 14 . . PUNCT dti-1426 147 1 second second ADJ dti-1426 147 2 , , PUNCT dti-1426 147 3 the the DET dti-1426 147 4 lack lack NOUN dti-1426 147 5 of of ADP dti-1426 147 6 a a DET dti-1426 147 7 quantitative quantitative ADJ dti-1426 147 8 and and CCONJ dti-1426 147 9 qualitative qualitative ADJ dti-1426 147 10 analysis analysis NOUN dti-1426 147 11 of of ADP dti-1426 147 12 the the DET dti-1426 147 13 neo neo NOUN dti-1426 147 14 - - NOUN dti-1426 147 15 matrix matrix NOUN dti-1426 147 16 deposited deposit VERB dti-1426 147 17 within within ADP dti-1426 147 18 the the DET dti-1426 147 19 biopolymer biopolymer NOUN dti-1426 147 20 in in ADP dti-1426 147 21 order order NOUN dti-1426 147 22 to to PART dti-1426 147 23 support support VERB dti-1426 147 24 the the DET dti-1426 147 25 findings finding NOUN dti-1426 147 26 on on ADP dti-1426 147 27 the the DET dti-1426 147 28 vascular vascular ADJ dti-1426 147 29 remodeling remodeling NOUN dti-1426 147 30 of of ADP dti-1426 147 31 the the DET dti-1426 147 32 tevg tevg PROPN dti-1426 147 33 . . PUNCT dti-1426 148 1 third third ADV dti-1426 148 2 , , PUNCT dti-1426 148 3 the the DET dti-1426 148 4 lack lack NOUN dti-1426 148 5 of of ADP dti-1426 148 6 a a DET dti-1426 148 7 control control NOUN dti-1426 148 8 group group NOUN dti-1426 148 9 implanted implant VERB dti-1426 148 10 with with ADP dti-1426 148 11 a a DET dti-1426 148 12 nonfunctionalized nonfunctionalize VERB dti-1426 148 13 plla plla NOUN dti-1426 148 14 graft graft NOUN dti-1426 148 15 or or CCONJ dti-1426 148 16 with with ADP dti-1426 148 17 current current ADJ dti-1426 148 18 state state NOUN dti-1426 148 19 - - PUNCT dti-1426 148 20 of of ADP dti-1426 148 21 - - PUNCT dti-1426 148 22 the the DET dti-1426 148 23 - - PUNCT dti-1426 148 24 art art NOUN dti-1426 148 25 graft graft NOUN dti-1426 148 26 routinely routinely ADV dti-1426 148 27 used use VERB dti-1426 148 28 in in ADP dti-1426 148 29 clinical clinical ADJ dti-1426 148 30 practice practice NOUN dti-1426 148 31 . . PUNCT dti-1426 149 1 as as SCONJ dti-1426 149 2 described describe VERB dti-1426 149 3 earlier early ADV dti-1426 149 4 , , PUNCT dti-1426 149 5 our our PRON dti-1426 149 6 preliminary preliminary ADJ dti-1426 149 7 in in ADP dti-1426 149 8 vivo vivo NOUN dti-1426 149 9 study study NOUN dti-1426 149 10 demonstrated demonstrate VERB dti-1426 149 11 an an DET dti-1426 149 12 excessive excessive ADJ dti-1426 149 13 acute acute ADJ dti-1426 149 14 failure failure NOUN dti-1426 149 15 of of ADP dti-1426 149 16 the the DET dti-1426 149 17 graft graft NOUN dti-1426 149 18 for for ADP dti-1426 149 19 thrombosis thrombosis NOUN dti-1426 149 20 in in ADP dti-1426 149 21 nonheparin nonheparin NOUN dti-1426 149 22 - - PUNCT dti-1426 149 23 functionalized functionalize VERB dti-1426 149 24 scaffolds scaffold NOUN dti-1426 149 25 , , PUNCT dti-1426 149 26 which which PRON dti-1426 149 27 led lead VERB dti-1426 149 28 us we PRON dti-1426 149 29 to to PART dti-1426 149 30 abandon abandon VERB dti-1426 149 31 this this DET dti-1426 149 32 approach approach NOUN dti-1426 149 33 . . PUNCT dti-1426 150 1 conversely conversely ADV dti-1426 150 2 , , PUNCT dti-1426 150 3 a a DET dti-1426 150 4 number number NOUN dti-1426 150 5 of of ADP dti-1426 150 6 reasons reason NOUN dti-1426 150 7 prevented prevent VERB dti-1426 150 8 to to PART dti-1426 150 9 add add VERB dti-1426 150 10 a a DET dti-1426 150 11 polyethylene polyethylene NOUN dti-1426 150 12 terephthalate terephthalate NOUN dti-1426 150 13 or or CCONJ dti-1426 150 14 ptfe ptfe ADJ dti-1426 150 15 graft graft NOUN dti-1426 150 16 control control NOUN dti-1426 150 17 group group NOUN dti-1426 150 18 in in ADP dti-1426 150 19 the the DET dti-1426 150 20 study study NOUN dti-1426 150 21 . . PUNCT dti-1426 151 1 first first ADV dti-1426 151 2 , , PUNCT dti-1426 151 3 the the DET dti-1426 151 4 technical technical ADJ dti-1426 151 5 difficulty difficulty NOUN dti-1426 151 6 in in ADP dti-1426 151 7 performing perform VERB dti-1426 151 8 the the DET dti-1426 151 9 vascular vascular ADJ dti-1426 151 10 reconstruction reconstruction NOUN dti-1426 151 11 model model NOUN dti-1426 151 12 used use VERB dti-1426 151 13 considering consider VERB dti-1426 151 14 the the DET dti-1426 151 15 discrepancy discrepancy NOUN dti-1426 151 16 in in ADP dti-1426 151 17 caliber caliber NOUN dti-1426 151 18 of of ADP dti-1426 151 19 the the DET dti-1426 151 20 native native ADJ dti-1426 151 21 aorta aorta NOUN dti-1426 151 22 and and CCONJ dti-1426 151 23 the the DET dti-1426 151 24 smallest small ADJ dti-1426 151 25 clinically clinically ADV dti-1426 151 26 available available ADJ dti-1426 151 27 prosthetic prosthetic ADJ dti-1426 151 28 graft graft NOUN dti-1426 151 29 , , PUNCT dti-1426 151 30 as as SCONJ dti-1426 151 31 no no DET dti-1426 151 32 other other ADJ dti-1426 151 33 experiences experience NOUN dti-1426 151 34 with with ADP dti-1426 151 35 these these DET dti-1426 151 36 type type NOUN dti-1426 151 37 of of ADP dti-1426 151 38 grafts graft NOUN dti-1426 151 39 are be AUX dti-1426 151 40 reported report VERB dti-1426 151 41 in in ADP dti-1426 151 42 the the DET dti-1426 151 43 literature literature NOUN dti-1426 151 44 for for ADP dti-1426 151 45 a a DET dti-1426 151 46 rabbit rabbit NOUN dti-1426 151 47 model model NOUN dti-1426 151 48 . . PUNCT dti-1426 152 1 second second ADJ dti-1426 152 2 , , PUNCT dti-1426 152 3 the the DET dti-1426 152 4 discrepancy discrepancy NOUN dti-1426 152 5 in in ADP dti-1426 152 6 caliber caliber NOUN dti-1426 152 7 would would AUX dti-1426 152 8 have have AUX dti-1426 152 9 added add VERB dti-1426 152 10 an an DET dti-1426 152 11 additional additional ADJ dti-1426 152 12 bias bias NOUN dti-1426 152 13 considering consider VERB dti-1426 152 14 the the DET dti-1426 152 15 possibility possibility NOUN dti-1426 152 16 of of ADP dti-1426 152 17 thrombosis thrombosis NOUN dti-1426 152 18 because because SCONJ dti-1426 152 19 of of ADP dti-1426 152 20 hemodynamic hemodynamic ADJ dti-1426 152 21 irregularity irregularity NOUN dti-1426 152 22 or or CCONJ dti-1426 152 23 turbulence turbulence NOUN dti-1426 152 24 . . PUNCT dti-1426 153 1 third third ADV dti-1426 153 2 , , PUNCT dti-1426 153 3 this this DET dti-1426 153 4 group group NOUN dti-1426 153 5 would would AUX dti-1426 153 6 have have AUX dti-1426 153 7 implied imply VERB dti-1426 153 8 to to PART dti-1426 153 9 administer administer VERB dti-1426 153 10 antiplatelet antiplatelet NOUN dti-1426 153 11 agents agent NOUN dti-1426 153 12 , , PUNCT dti-1426 153 13 as as SCONJ dti-1426 153 14 normally normally ADV dti-1426 153 15 required require VERB dti-1426 153 16 in in ADP dti-1426 153 17 clinical clinical ADJ dti-1426 153 18 settings setting NOUN dti-1426 153 19 to to PART dti-1426 153 20 avoid avoid VERB dti-1426 153 21 thrombosis thrombosis NOUN dti-1426 153 22 , , PUNCT dti-1426 153 23 weakening weaken VERB dti-1426 153 24 the the DET dti-1426 153 25 main main ADJ dti-1426 153 26 aims aim NOUN dti-1426 153 27 of of ADP dti-1426 153 28 this this DET dti-1426 153 29 study study NOUN dti-1426 153 30 , , PUNCT dti-1426 153 31 ie ie X dti-1426 153 32 , , PUNCT dti-1426 153 33 to to PART dti-1426 153 34 test test VERB dti-1426 153 35 the the DET dti-1426 153 36 actual actual ADJ dti-1426 153 37 ability ability NOUN dti-1426 153 38 of of ADP dti-1426 153 39 a a DET dti-1426 153 40 tevg tevg PROPN dti-1426 153 41 to to PART dti-1426 153 42 constitute constitute VERB dti-1426 153 43 a a DET dti-1426 153 44 valid valid ADJ dti-1426 153 45 alternative alternative NOUN dti-1426 153 46 to to ADP dti-1426 153 47 autologous autologous ADJ dti-1426 153 48 conduits conduit NOUN dti-1426 153 49 guaranteeing guarantee VERB dti-1426 153 50 patency patency NOUN dti-1426 153 51 and and CCONJ dti-1426 153 52 mechanical mechanical ADJ dti-1426 153 53 resistance resistance NOUN dti-1426 153 54 . . PUNCT dti-1426 154 1 in in ADP dti-1426 154 2 this this DET dti-1426 154 3 context context NOUN dti-1426 154 4 , , PUNCT dti-1426 154 5 a a DET dti-1426 154 6 longer long ADJ dti-1426 154 7 term term NOUN dti-1426 154 8 follow follow VERB dti-1426 154 9 - - PUNCT dti-1426 154 10 up up NOUN dti-1426 154 11 would would AUX dti-1426 154 12 have have AUX dti-1426 154 13 been be AUX dti-1426 154 14 useful useful ADJ dti-1426 154 15 to to PART dti-1426 154 16 evaluate evaluate VERB dti-1426 154 17 vascular vascular ADJ dti-1426 154 18 reconstitution reconstitution NOUN dti-1426 154 19 and and CCONJ dti-1426 154 20 potential potential ADJ dti-1426 154 21 side side NOUN dti-1426 154 22 effects effect NOUN dti-1426 154 23 . . PUNCT dti-1426 155 1 finally finally ADV dti-1426 155 2 , , PUNCT dti-1426 155 3 this this DET dti-1426 155 4 study study NOUN dti-1426 155 5 was be AUX dti-1426 155 6 only only ADV dti-1426 155 7 preliminary preliminary ADJ dti-1426 155 8 and and CCONJ dti-1426 155 9 speculative speculative ADJ dti-1426 155 10 in in ADP dti-1426 155 11 its its PRON dti-1426 155 12 nature nature NOUN dti-1426 155 13 and and CCONJ dti-1426 155 14 was be AUX dti-1426 155 15 performed perform VERB dti-1426 155 16 as as ADP dti-1426 155 17 a a DET dti-1426 155 18 proof proof NOUN dti-1426 155 19 - - PUNCT dti-1426 155 20 of of ADP dti-1426 155 21 - - PUNCT dti-1426 155 22 principle principle NOUN dti-1426 155 23 to to PART dti-1426 155 24 test test VERB dti-1426 155 25 the the DET dti-1426 155 26 in in ADP dti-1426 155 27 vivo vivo ADJ dti-1426 155 28 effectiveness effectiveness NOUN dti-1426 155 29 of of ADP dti-1426 155 30 our our PRON dti-1426 155 31 previously previously ADV dti-1426 155 32 developed develop VERB dti-1426 155 33 armored armored ADJ dti-1426 155 34 prosthesis prosthesis NOUN dti-1426 155 35 in in ADP dti-1426 155 36 terms term NOUN dti-1426 155 37 of of ADP dti-1426 155 38 patency patency NOUN dti-1426 155 39 and and CCONJ dti-1426 155 40 resistance resistance NOUN dti-1426 155 41 . . PUNCT dti-1426 156 1 the the DET dti-1426 156 2 results result NOUN dti-1426 156 3 of of ADP dti-1426 156 4 this this DET dti-1426 156 5 preliminary preliminary ADJ dti-1426 156 6 study study NOUN dti-1426 156 7 might might AUX dti-1426 156 8 warrant warrant VERB dti-1426 156 9 for for ADP dti-1426 156 10 further far ADV dti-1426 156 11 larger large ADJ dti-1426 156 12 controlled control VERB dti-1426 156 13 in in ADP dti-1426 156 14 vivo vivo ADJ dti-1426 156 15 studies study NOUN dti-1426 156 16 to to PART dti-1426 156 17 further far ADV dti-1426 156 18 confirm confirm VERB dti-1426 156 19 these these DET dti-1426 156 20 findings finding NOUN dti-1426 156 21 . . PUNCT dti-1426 157 1 author author NOUN dti-1426 157 2 contributions contribution NOUN dti-1426 157 3 conceived conceive VERB dti-1426 157 4 and and CCONJ dti-1426 157 5 designed design VERB dti-1426 157 6 the the DET dti-1426 157 7 experiments experiment NOUN dti-1426 157 8 : : PUNCT dti-1426 157 9 cs cs X dti-1426 157 10 . . PROPN dti-1426 157 11 analyzed analyze VERB dti-1426 157 12 the the DET dti-1426 157 13 data datum NOUN dti-1426 157 14 : : PUNCT dti-1426 157 15 fn fn NOUN dti-1426 157 16 , , PUNCT dti-1426 157 17 fdm fdm NOUN dti-1426 157 18 , , PUNCT dti-1426 157 19 ar ar PROPN dti-1426 157 20 . . PROPN dti-1426 157 21 wrote write VERB dti-1426 157 22 the the DET dti-1426 157 23 first first ADJ dti-1426 157 24 draft draft NOUN dti-1426 157 25 of of ADP dti-1426 157 26 the the DET dti-1426 157 27 manuscript manuscript NOUN dti-1426 157 28 : : PUNCT dti-1426 157 29 cs cs PROPN dti-1426 157 30 , , PUNCT dti-1426 157 31 ps ps PROPN dti-1426 157 32 , , PUNCT dti-1426 157 33 fs fs PROPN dti-1426 157 34 . . PROPN dti-1426 157 35 contributed contribute VERB dti-1426 157 36 to to ADP dti-1426 157 37 the the DET dti-1426 157 38 writing writing NOUN dti-1426 157 39 of of ADP dti-1426 157 40 the the DET dti-1426 157 41 manuscript manuscript NOUN dti-1426 157 42 : : PUNCT dti-1426 157 43 fn fn NOUN dti-1426 157 44 , , PUNCT dti-1426 157 45 ar ar PROPN dti-1426 157 46 , , PUNCT dti-1426 157 47 mc mc PROPN dti-1426 157 48 , , PUNCT dti-1426 157 49 mt mt PROPN dti-1426 157 50 . . PROPN dti-1426 157 51 agree agree VERB dti-1426 157 52 with with ADP dti-1426 157 53 manuscript manuscript NOUN dti-1426 157 54 results result NOUN dti-1426 157 55 and and CCONJ dti-1426 157 56 conclusions conclusion NOUN dti-1426 157 57 : : PUNCT dti-1426 157 58 ar ar PROPN dti-1426 157 59 , , PUNCT dti-1426 157 60 fs fs PROPN dti-1426 157 61 , , PUNCT dti-1426 157 62 mc mc PROPN dti-1426 157 63 , , PUNCT dti-1426 157 64 mt mt PROPN dti-1426 157 65 . . PROPN dti-1426 158 1 jointly jointly ADV dti-1426 158 2 developed develop VERB dti-1426 158 3 the the DET dti-1426 158 4 structure structure NOUN dti-1426 158 5 and and CCONJ dti-1426 158 6 arguments argument NOUN dti-1426 158 7 for for ADP dti-1426 158 8 the the DET dti-1426 158 9 paper paper NOUN dti-1426 158 10 : : PUNCT dti-1426 158 11 cs cs PROPN dti-1426 158 12 , , PUNCT dti-1426 158 13 ar ar PROPN dti-1426 158 14 , , PUNCT dti-1426 158 15 fn fn NOUN dti-1426 158 16 , , PUNCT dti-1426 158 17 fs fs PROPN dti-1426 158 18 , , PUNCT dti-1426 158 19 ps ps PROPN dti-1426 158 20 . . PROPN dti-1426 158 21 made make VERB dti-1426 158 22 critical critical ADJ dti-1426 158 23 revisions revision NOUN dti-1426 158 24 and and CCONJ dti-1426 158 25 approved approve VERB dti-1426 158 26 final final ADJ dti-1426 158 27 version version NOUN dti-1426 158 28 : : PUNCT dti-1426 158 29 fs fs PROPN dti-1426 158 30 , , PUNCT dti-1426 158 31 mc mc PROPN dti-1426 158 32 , , PUNCT dti-1426 158 33 mt mt PROPN dti-1426 158 34 , , PUNCT dti-1426 158 35 ar ar PROPN dti-1426 158 36 , , PUNCT dti-1426 158 37 fn fn NOUN dti-1426 158 38 . . PUNCT dti-1426 159 1 all all DET dti-1426 159 2 authors author NOUN dti-1426 159 3 reviewed review VERB dti-1426 159 4 and and CCONJ dti-1426 159 5 approved approve VERB dti-1426 159 6 of of ADP dti-1426 159 7 the the DET dti-1426 159 8 final final ADJ dti-1426 159 9 manuscript manuscript NOUN dti-1426 159 10 . . PUNCT dti-1426 160 1 references reference NOUN dti-1426 160 2 1 1 NUM dti-1426 160 3 . . PUNCT dti-1426 160 4 xu xu PROPN dti-1426 161 1 zc zc PROPN dti-1426 161 2 , , PUNCT dti-1426 161 3 zhang zhang PROPN dti-1426 161 4 wj wj PROPN dti-1426 161 5 , , PUNCT dti-1426 161 6 li li PROPN dti-1426 161 7 h h PROPN dti-1426 161 8 , , PUNCT dti-1426 161 9 et et PROPN dti-1426 161 10 al al PROPN dti-1426 161 11 . . PUNCT dti-1426 161 12 engineering engineering NOUN dti-1426 161 13 of of ADP dti-1426 161 14 an an DET dti-1426 161 15 elastic elastic ADJ dti-1426 161 16 large large ADJ dti-1426 161 17 muscular muscular ADJ dti-1426 161 18 vessel vessel NOUN dti-1426 161 19 wall wall NOUN dti-1426 161 20 with with ADP dti-1426 161 21 pulsatile pulsatile NOUN dti-1426 161 22 stimulation stimulation NOUN dti-1426 161 23 in in ADP dti-1426 161 24 bioreactor bioreactor NOUN dti-1426 161 25 . . PUNCT dti-1426 162 1 biomaterials biomaterial NOUN dti-1426 162 2 . . PUNCT dti-1426 163 1 2008;29(10 2008;29(10 NUM dti-1426 163 2 ): ): PUNCT dti-1426 163 3 1464–1472 1464–1472 NUM dti-1426 163 4 . . PUNCT dti-1426 164 1 2 2 NUM dti-1426 164 2 . . X dti-1426 164 3 yang yang PROPN dti-1426 164 4 f f PROPN dti-1426 164 5 , , PUNCT dti-1426 164 6 murugan murugan PROPN dti-1426 164 7 r r PROPN dti-1426 164 8 , , PUNCT dti-1426 164 9 wang wang PROPN dti-1426 164 10 s s PROPN dti-1426 164 11 , , PUNCT dti-1426 164 12 et et PROPN dti-1426 164 13 al al PROPN dti-1426 164 14 . . PUNCT dti-1426 165 1 electrospinning electrospinne VERB dti-1426 165 2 of of ADP dti-1426 165 3 nano nano NOUN dti-1426 165 4 / / SYM dti-1426 165 5 micro micro ADJ dti-1426 165 6 scale scale NOUN dti-1426 165 7 poly(llactic poly(llactic ADJ dti-1426 165 8 acid acid NOUN dti-1426 165 9 ) ) PUNCT dti-1426 165 10 aligned aligned ADJ dti-1426 165 11 fibers fiber NOUN dti-1426 165 12 and and CCONJ dti-1426 165 13 their their PRON dti-1426 165 14 potential potential NOUN dti-1426 165 15 in in ADP dti-1426 165 16 neural neural ADJ dti-1426 165 17 tissue tissue NOUN dti-1426 165 18 engineering engineering NOUN dti-1426 165 19 . . PUNCT dti-1426 166 1 biomaterials biomaterial NOUN dti-1426 166 2 . . PUNCT dti-1426 167 1 2005;26(15):2603–2610 2005;26(15):2603–2610 NUM dti-1426 167 2 . . PUNCT dti-1426 168 1 3 3 X dti-1426 168 2 . . X dti-1426 168 3 shinoka shinoka PROPN dti-1426 168 4 t t PROPN dti-1426 168 5 , , PUNCT dti-1426 168 6 shum shum PROPN dti-1426 168 7 - - PUNCT dti-1426 168 8 tim tim PROPN dti-1426 168 9 d d PROPN dti-1426 168 10 , , PUNCT dti-1426 168 11 ma ma PROPN dti-1426 168 12 px px PROPN dti-1426 168 13 , , PUNCT dti-1426 168 14 et et PROPN dti-1426 168 15 al al PROPN dti-1426 168 16 . . PUNCT dti-1426 169 1 creation creation NOUN dti-1426 169 2 of of ADP dti-1426 169 3 viable viable ADJ dti-1426 169 4 pulmonary pulmonary ADJ dti-1426 169 5 artery artery NOUN dti-1426 169 6 autografts autograft NOUN dti-1426 169 7 through through ADP dti-1426 169 8 tissue tissue NOUN dti-1426 169 9 engineering engineering NOUN dti-1426 169 10 . . PUNCT dti-1426 170 1 j j PROPN dti-1426 170 2 thorac thorac PROPN dti-1426 170 3 cardiovasc cardiovasc PROPN dti-1426 170 4 surg surg PROPN dti-1426 170 5 . . PUNCT dti-1426 171 1 1998;115(3 1998;115(3 NUM dti-1426 171 2 ): ): PUNCT dti-1426 172 1 536–545 536–545 NUM dti-1426 172 2 . . PUNCT dti-1426 173 1 [ [ X dti-1426 173 2 discussion discussion NOUN dti-1426 173 3 545–536 545–536 NUM dti-1426 173 4 ] ] PUNCT dti-1426 173 5 . . PUNCT dti-1426 174 1 4 4 X dti-1426 174 2 . . X dti-1426 174 3 shin’oka shin’oka PROPN dti-1426 174 4 t t PROPN dti-1426 174 5 , , PUNCT dti-1426 174 6 matsumura matsumura ADJ dti-1426 174 7 g g PROPN dti-1426 174 8 , , PUNCT dti-1426 174 9 hibino hibino PROPN dti-1426 174 10 n n CCONJ dti-1426 174 11 , , PUNCT dti-1426 174 12 et et PROPN dti-1426 174 13 al al PROPN dti-1426 174 14 . . PROPN dti-1426 175 1 midterm midterm PROPN dti-1426 175 2 clinical clinical ADJ dti-1426 175 3 result result NOUN dti-1426 175 4 of of ADP dti-1426 175 5 tissueengineered tissueengineere VERB dti-1426 175 6 vascular vascular ADJ dti-1426 175 7 autografts autograft NOUN dti-1426 175 8 seeded seed VERB dti-1426 175 9 with with ADP dti-1426 175 10 autologous autologous ADJ dti-1426 175 11 bone bone NOUN dti-1426 175 12 marrow marrow NOUN dti-1426 175 13 cells cell NOUN dti-1426 175 14 . . PUNCT dti-1426 176 1 j j PROPN dti-1426 176 2 thorac thorac PROPN dti-1426 176 3 cardiovasc cardiovasc PROPN dti-1426 176 4 surg surg PROPN dti-1426 176 5 . . PUNCT dti-1426 177 1 2005;129(6):1330–1338 2005;129(6):1330–1338 NUM dti-1426 177 2 . . NOUN dti-1426 177 3 5 5 NUM dti-1426 177 4 . . X dti-1426 177 5 he he PRON dti-1426 177 6 w w PROPN dti-1426 177 7 , , PUNCT dti-1426 177 8 ma ma PROPN dti-1426 177 9 z z PROPN dti-1426 177 10 , , PUNCT dti-1426 177 11 teo teo PROPN dti-1426 177 12 we we PRON dti-1426 177 13 , , PUNCT dti-1426 177 14 et et PROPN dti-1426 177 15 al al PROPN dti-1426 177 16 . . PROPN dti-1426 178 1 tubular tubular ADJ dti-1426 178 2 nanofiber nanofiber NOUN dti-1426 178 3 scaffolds scaffold NOUN dti-1426 178 4 for for ADP dti-1426 178 5 tissue tissue NOUN dti-1426 178 6 engineered engineer VERB dti-1426 178 7 small small ADJ dti-1426 178 8 - - PUNCT dti-1426 178 9 diameter diameter NOUN dti-1426 178 10 vascular vascular ADJ dti-1426 178 11 grafts graft NOUN dti-1426 178 12 . . PUNCT dti-1426 179 1 j j PROPN dti-1426 179 2 biomed biome VERB dti-1426 179 3 mater mater NOUN dti-1426 179 4 res re NOUN dti-1426 179 5 a. a. NOUN dti-1426 179 6 2009;90(1):205–216 2009;90(1):205–216 NUM dti-1426 179 7 . . PROPN dti-1426 180 1 6 6 NUM dti-1426 180 2 . . PUNCT dti-1426 181 1 carr carr PROPN dti-1426 181 2 hm hm PROPN dti-1426 181 3 , , PUNCT dti-1426 181 4 vohra vohra PROPN dti-1426 181 5 r r PROPN dti-1426 181 6 , , PUNCT dti-1426 181 7 sharma sharma PROPN dti-1426 181 8 h h PROPN dti-1426 181 9 , , PUNCT dti-1426 181 10 et et PROPN dti-1426 181 11 al al PROPN dti-1426 181 12 . . PUNCT dti-1426 182 1 endothelial endothelial ADJ dti-1426 182 2 cell cell NOUN dti-1426 182 3 seeding seed VERB dti-1426 182 4 kinetics kinetic NOUN dti-1426 182 5 under under ADP dti-1426 182 6 chronic chronic ADJ dti-1426 182 7 flow flow NOUN dti-1426 182 8 in in ADP dti-1426 182 9 prosthetic prosthetic ADJ dti-1426 182 10 grafts graft NOUN dti-1426 182 11 . . PUNCT dti-1426 183 1 ann ann PROPN dti-1426 183 2 vasc vasc PROPN dti-1426 183 3 surg surg PROPN dti-1426 183 4 . . PUNCT dti-1426 184 1 1996;10(5):469–475 1996;10(5):469–475 NUM dti-1426 184 2 . . NOUN dti-1426 185 1 7 7 NUM dti-1426 185 2 . . X dti-1426 185 3 rosenman rosenman PROPN dti-1426 185 4 je je PROPN dti-1426 185 5 , , PUNCT dti-1426 185 6 kempczinski kempczinski PROPN dti-1426 185 7 rf rf PROPN dti-1426 185 8 , , PUNCT dti-1426 185 9 pearce pearce PROPN dti-1426 185 10 wh wh PROPN dti-1426 185 11 , , PUNCT dti-1426 185 12 et et PROPN dti-1426 185 13 al al PROPN dti-1426 185 14 . . PUNCT dti-1426 185 15 kinetics kinetic NOUN dti-1426 185 16 of of ADP dti-1426 185 17 endothelial endothelial ADJ dti-1426 185 18 cell cell NOUN dti-1426 185 19 seeding seeding NOUN dti-1426 185 20 . . PUNCT dti-1426 186 1 j j PROPN dti-1426 186 2 vasc vasc PROPN dti-1426 186 3 surg surg PROPN dti-1426 186 4 . . PUNCT dti-1426 187 1 1985;2(6):778–784 1985;2(6):778–784 NUM dti-1426 187 2 . . NOUN dti-1426 187 3 8 8 NUM dti-1426 187 4 . . PUNCT dti-1426 187 5 greisler greisler PROPN dti-1426 187 6 hp hp PROPN dti-1426 187 7 , , PUNCT dti-1426 187 8 cziperle cziperle NOUN dti-1426 187 9 dj dj PROPN dti-1426 187 10 , , PUNCT dti-1426 187 11 kim kim PROPN dti-1426 187 12 du du PROPN dti-1426 187 13 , , PUNCT dti-1426 187 14 et et PROPN dti-1426 187 15 al al PROPN dti-1426 187 16 . . PROPN dti-1426 187 17 enhanced enhance VERB dti-1426 187 18 endothelialization endothelialization NOUN dti-1426 187 19 of of ADP dti-1426 187 20 expanded expand VERB dti-1426 187 21 polytetrafluoroethylene polytetrafluoroethylene NOUN dti-1426 187 22 grafts graft NOUN dti-1426 187 23 by by ADP dti-1426 187 24 fibroblast fibroblast ADJ dti-1426 187 25 growth growth NOUN dti-1426 187 26 factor factor NOUN dti-1426 187 27 type type NOUN dti-1426 187 28 1 1 NUM dti-1426 187 29 pretreatment pretreatment NOUN dti-1426 187 30 . . PUNCT dti-1426 188 1 surgery surgery NOUN dti-1426 188 2 . . PUNCT dti-1426 189 1 1992;112(2):244–254 1992;112(2):244–254 NUM dti-1426 189 2 . . PUNCT dti-1426 190 1 [ [ X dti-1426 190 2 discussion discussion NOUN dti-1426 190 3 254–245 254–245 NUM dti-1426 190 4 ] ] PUNCT dti-1426 190 5 . . PUNCT dti-1426 191 1 9 9 X dti-1426 191 2 . . X dti-1426 191 3 spadaccio spadaccio PROPN dti-1426 191 4 c c X dti-1426 191 5 , , PUNCT dti-1426 191 6 chello chello PROPN dti-1426 191 7 m m PROPN dti-1426 191 8 , , PUNCT dti-1426 191 9 trombetta trombetta PROPN dti-1426 191 10 m m PROPN dti-1426 191 11 , , PUNCT dti-1426 191 12 et et PROPN dti-1426 191 13 al al PROPN dti-1426 191 14 . . PROPN dti-1426 191 15 drug drug PROPN dti-1426 191 16 releasing release VERB dti-1426 191 17 systems system NOUN dti-1426 191 18 in in ADP dti-1426 191 19 cardiovascular cardiovascular ADJ dti-1426 191 20 tissue tissue NOUN dti-1426 191 21 engineering engineering NOUN dti-1426 191 22 . . PUNCT dti-1426 192 1 j j PROPN dti-1426 192 2 cell cell PROPN dti-1426 192 3 mol mol ADP dti-1426 192 4 med med PROPN dti-1426 192 5 . . PUNCT dti-1426 193 1 2009;13(3):422–439 2009;13(3):422–439 NUM dti-1426 193 2 . . PUNCT dti-1426 194 1 10 10 NUM dti-1426 194 2 . . X dti-1426 194 3 mo mo PROPN dti-1426 194 4 xm xm PROPN dti-1426 194 5 , , PUNCT dti-1426 194 6 xu xu PROPN dti-1426 194 7 cy cy PROPN dti-1426 194 8 , , PUNCT dti-1426 194 9 kotaki kotaki PROPN dti-1426 194 10 m m PROPN dti-1426 194 11 , , PUNCT dti-1426 195 1 et et PROPN dti-1426 195 2 al al PROPN dti-1426 195 3 . . PROPN dti-1426 195 4 electrospun electrospun PROPN dti-1426 195 5 p(lla p(lla NOUN dti-1426 195 6 - - PUNCT dti-1426 195 7 cl cl NOUN dti-1426 195 8 ) ) PUNCT dti-1426 195 9 nanofiber nanofiber NOUN dti-1426 195 10 : : PUNCT dti-1426 195 11 a a DET dti-1426 195 12 biomimetic biomimetic ADJ dti-1426 195 13 extracellular extracellular ADJ dti-1426 195 14 matrix matrix NOUN dti-1426 195 15 for for ADP dti-1426 195 16 smooth smooth ADJ dti-1426 195 17 muscle muscle NOUN dti-1426 195 18 cell cell NOUN dti-1426 195 19 and and CCONJ dti-1426 195 20 endothelial endothelial ADJ dti-1426 195 21 cell cell NOUN dti-1426 195 22 proliferation proliferation NOUN dti-1426 195 23 . . PUNCT dti-1426 196 1 biomaterials biomaterial NOUN dti-1426 196 2 . . PUNCT dti-1426 197 1 2004;25(10):1883–1890 2004;25(10):1883–1890 VERB dti-1426 197 2 . . NOUN dti-1426 197 3 11 11 NUM dti-1426 197 4 . . X dti-1426 197 5 badami badami NOUN dti-1426 197 6 as as ADP dti-1426 197 7 , , PUNCT dti-1426 197 8 kreke kreke ADJ dti-1426 197 9 mr mr PROPN dti-1426 197 10 , , PUNCT dti-1426 197 11 thompson thompson PROPN dti-1426 197 12 ms ms PROPN dti-1426 197 13 , , PUNCT dti-1426 197 14 et et PROPN dti-1426 197 15 al al PROPN dti-1426 197 16 . . PROPN dti-1426 197 17 effect effect NOUN dti-1426 197 18 of of ADP dti-1426 197 19 fiber fiber NOUN dti-1426 197 20 diameter diameter NOUN dti-1426 197 21 on on ADP dti-1426 197 22 spreading spread VERB dti-1426 197 23 , , PUNCT dti-1426 197 24 proliferation proliferation NOUN dti-1426 197 25 , , PUNCT dti-1426 197 26 and and CCONJ dti-1426 197 27 differentiation differentiation NOUN dti-1426 197 28 of of ADP dti-1426 197 29 osteoblastic osteoblastic ADJ dti-1426 197 30 cells cell NOUN dti-1426 197 31 on on ADP dti-1426 197 32 electrospun electrospun NOUN dti-1426 197 33 poly(lactic poly(lactic PROPN dti-1426 197 34 acid acid NOUN dti-1426 197 35 ) ) PUNCT dti-1426 197 36 substrates substrate NOUN dti-1426 197 37 . . PUNCT dti-1426 197 38 biomaterials biomaterial NOUN dti-1426 197 39 . . PUNCT dti-1426 198 1 2006;27(4):596–606 2006;27(4):596–606 NUM dti-1426 198 2 . . NOUN dti-1426 199 1 12 12 NUM dti-1426 199 2 . . PUNCT dti-1426 200 1 xu xu PROPN dti-1426 201 1 c c X dti-1426 201 2 , , PUNCT dti-1426 201 3 inai inai PROPN dti-1426 201 4 r r PROPN dti-1426 201 5 , , PUNCT dti-1426 201 6 kotaki kotaki PROPN dti-1426 201 7 m m PROPN dti-1426 201 8 , , PUNCT dti-1426 201 9 et et PROPN dti-1426 201 10 al al PROPN dti-1426 201 11 . . PROPN dti-1426 201 12 electrospun electrospun PROPN dti-1426 201 13 nanofiber nanofiber PROPN dti-1426 201 14 fabrication fabrication NOUN dti-1426 201 15 as as ADP dti-1426 201 16 synthetic synthetic ADJ dti-1426 201 17 extracellular extracellular ADJ dti-1426 201 18 matrix matrix NOUN dti-1426 201 19 and and CCONJ dti-1426 201 20 its its PRON dti-1426 201 21 potential potential NOUN dti-1426 201 22 for for ADP dti-1426 201 23 vascular vascular ADJ dti-1426 201 24 tissue tissue NOUN dti-1426 201 25 engineering engineering NOUN dti-1426 201 26 . . PUNCT dti-1426 202 1 tissue tissue NOUN dti-1426 202 2 eng eng PROPN dti-1426 202 3 . . PUNCT dti-1426 203 1 2004;10(7–8):1160–1168 2004;10(7–8):1160–1168 NOUN dti-1426 203 2 . . PUNCT dti-1426 203 3 13 13 NUM dti-1426 203 4 . . PUNCT dti-1426 203 5 spadaccio spadaccio PROPN dti-1426 203 6 c c NOUN dti-1426 203 7 , , PUNCT dti-1426 203 8 rainer rainer NOUN dti-1426 203 9 a a PRON dti-1426 203 10 , , PUNCT dti-1426 203 11 centola centola PROPN dti-1426 203 12 m m PROPN dti-1426 203 13 , , PUNCT dti-1426 203 14 et et PROPN dti-1426 203 15 al al PROPN dti-1426 203 16 . . PROPN dti-1426 203 17 heparin heparin NOUN dti-1426 203 18 - - PUNCT dti-1426 203 19 releasing release VERB dti-1426 203 20 scaffold scaffold NOUN dti-1426 203 21 for for ADP dti-1426 203 22 stem stem NOUN dti-1426 203 23 cells cell NOUN dti-1426 203 24 : : PUNCT dti-1426 203 25 a a DET dti-1426 203 26 differentiating differentiate VERB dti-1426 203 27 device device NOUN dti-1426 203 28 for for ADP dti-1426 203 29 vascular vascular ADJ dti-1426 203 30 aims aim NOUN dti-1426 203 31 . . PUNCT dti-1426 204 1 regen regen PROPN dti-1426 204 2 med med PROPN dti-1426 204 3 . . PUNCT dti-1426 205 1 2010;5(4):645–657 2010;5(4):645–657 NUM dti-1426 205 2 . . PUNCT dti-1426 206 1 14 14 NUM dti-1426 206 2 . . PUNCT dti-1426 207 1 hashi hashi PROPN dti-1426 207 2 ck ck PROPN dti-1426 207 3 , , PUNCT dti-1426 207 4 zhu zhu PROPN dti-1426 207 5 y y PROPN dti-1426 207 6 , , PUNCT dti-1426 207 7 yang yang PROPN dti-1426 207 8 gy gy PROPN dti-1426 207 9 , , PUNCT dti-1426 207 10 et et PROPN dti-1426 207 11 al al PROPN dti-1426 207 12 . . PROPN dti-1426 207 13 antithrombogenic antithrombogenic ADJ dti-1426 207 14 property property NOUN dti-1426 207 15 of of ADP dti-1426 207 16 bone bone NOUN dti-1426 207 17 marrow marrow NOUN dti-1426 207 18 mesenchymal mesenchymal NOUN dti-1426 207 19 stem stem NOUN dti-1426 207 20 cells cell NOUN dti-1426 207 21 in in ADP dti-1426 207 22 nanofibrous nanofibrous ADJ dti-1426 207 23 vascular vascular ADJ dti-1426 207 24 grafts graft NOUN dti-1426 207 25 . . PUNCT dti-1426 208 1 proc proc PROPN dti-1426 208 2 natl natl PROPN dti-1426 208 3 acad acad PROPN dti-1426 208 4 sci sci PROPN dti-1426 208 5 u u PROPN dti-1426 208 6     SPACE dti-1426 208 7 s s PART dti-1426 208 8     SPACE dti-1426 208 9 a. a. NOUN dti-1426 208 10 2007;104(29):11915–11920 2007;104(29):11915–11920 NUM dti-1426 208 11 . . PUNCT dti-1426 208 12 15 15 NUM dti-1426 208 13 . . PUNCT dti-1426 209 1 barnes barnes PROPN dti-1426 209 2 cp cp PROPN dti-1426 209 3 , , PUNCT dti-1426 209 4 sell sell VERB dti-1426 209 5 sa sa PROPN dti-1426 209 6 , , PUNCT dti-1426 209 7 boland boland PROPN dti-1426 209 8 ed ed PROPN dti-1426 209 9 , , PUNCT dti-1426 209 10 et et PROPN dti-1426 209 11 al al PROPN dti-1426 209 12 . . PROPN dti-1426 209 13 nanofiber nanofiber PROPN dti-1426 209 14 technology technology NOUN dti-1426 209 15 : : PUNCT dti-1426 209 16 designing design VERB dti-1426 209 17 the the DET dti-1426 209 18 next next ADJ dti-1426 209 19 generation generation NOUN dti-1426 209 20 of of ADP dti-1426 209 21 tissue tissue NOUN dti-1426 209 22 engineering engineering NOUN dti-1426 209 23 scaffolds scaffold NOUN dti-1426 209 24 . . PUNCT dti-1426 210 1 adv adv PROPN dti-1426 210 2 drug drug PROPN dti-1426 210 3 deliv deliv PROPN dti-1426 210 4 rev rev VERB dti-1426 210 5 . . PUNCT dti-1426 211 1 2007;59(14 2007;59(14 NUM dti-1426 211 2 ): ): PUNCT dti-1426 211 3 1413–1433 1413–1433 NUM dti-1426 211 4 . . PUNCT dti-1426 212 1 16 16 NUM dti-1426 212 2 . . PUNCT dti-1426 213 1 murugan murugan PROPN dti-1426 213 2 r r PROPN dti-1426 213 3 , , PUNCT dti-1426 213 4 ramakrishna ramakrishna PROPN dti-1426 213 5 s. s. PROPN dti-1426 213 6 nano nano PROPN dti-1426 213 7 - - PUNCT dti-1426 213 8 featured feature VERB dti-1426 213 9 scaffolds scaffold NOUN dti-1426 213 10 for for ADP dti-1426 213 11 tissue tissue NOUN dti-1426 213 12 engineering engineering NOUN dti-1426 213 13 : : PUNCT dti-1426 213 14 a a DET dti-1426 213 15 review review NOUN dti-1426 213 16 of of ADP dti-1426 213 17 spinning spinning NOUN dti-1426 213 18 methodologies methodology NOUN dti-1426 213 19 . . PUNCT dti-1426 214 1 tissue tissue NOUN dti-1426 214 2 eng eng PROPN dti-1426 214 3 . . PUNCT dti-1426 214 4 2006;12(3):435–447 2006;12(3):435–447 PROPN dti-1426 214 5 . . PROPN dti-1426 214 6 17 17 NUM dti-1426 214 7 . . PUNCT dti-1426 215 1 lee lee PROPN dti-1426 215 2 sj sj PROPN dti-1426 215 3 , , PUNCT dti-1426 215 4 yoo yoo PROPN dti-1426 215 5 jj jj PROPN dti-1426 215 6 , , PUNCT dti-1426 215 7 lim lim PROPN dti-1426 215 8 gj gj PROPN dti-1426 215 9 , , PUNCT dti-1426 215 10 et et PROPN dti-1426 215 11 al al PROPN dti-1426 215 12 . . PROPN dti-1426 216 1 in in ADP dti-1426 216 2 vitro vitro X dti-1426 216 3 evaluation evaluation NOUN dti-1426 216 4 of of ADP dti-1426 216 5 electrospun electrospun PROPN dti-1426 216 6 nanofiber nanofiber NOUN dti-1426 216 7 scaffolds scaffold NOUN dti-1426 216 8 for for ADP dti-1426 216 9 vascular vascular ADJ dti-1426 216 10 graft graft NOUN dti-1426 216 11 application application NOUN dti-1426 216 12 . . PUNCT dti-1426 217 1 j j PROPN dti-1426 217 2 biomed biome VERB dti-1426 217 3 mater mater NOUN dti-1426 217 4 res re NOUN dti-1426 217 5 a. a. NOUN dti-1426 217 6 2007;83(4):999–1008 2007;83(4):999–1008 PROPN dti-1426 217 7 . . PUNCT dti-1426 218 1 18 18 NUM dti-1426 218 2 . . PUNCT dti-1426 219 1 mironov mironov PROPN dti-1426 219 2 v v PROPN dti-1426 219 3 , , PUNCT dti-1426 219 4 kasyanov kasyanov PROPN dti-1426 219 5 v v PROPN dti-1426 219 6 , , PUNCT dti-1426 219 7 markwald markwald PROPN dti-1426 219 8 rr rr PROPN dti-1426 219 9 . . PUNCT dti-1426 220 1 nanotechnology nanotechnology PROPN dti-1426 220 2 in in ADP dti-1426 220 3 vascular vascular ADJ dti-1426 220 4 tissue tissue NOUN dti-1426 220 5 engineering engineering NOUN dti-1426 220 6 : : PUNCT dti-1426 220 7 from from ADP dti-1426 220 8 nanoscaffolding nanoscaffolde VERB dti-1426 220 9 towards towards ADP dti-1426 220 10 rapid rapid ADJ dti-1426 220 11 vessel vessel NOUN dti-1426 220 12 biofabrication biofabrication NOUN dti-1426 220 13 . . PUNCT dti-1426 221 1 trends trend NOUN dti-1426 221 2 biotechnol biotechnol VERB dti-1426 221 3 . . PUNCT dti-1426 222 1 2008;26(6):338–344 2008;26(6):338–344 NUM dti-1426 222 2 . . PROPN dti-1426 222 3 19 19 NUM dti-1426 222 4 . . PUNCT dti-1426 223 1 kim kim PROPN dti-1426 223 2 sh sh PROPN dti-1426 223 3 , , PUNCT dti-1426 223 4 nederberg nederberg PROPN dti-1426 223 5 f f PROPN dti-1426 223 6 , , PUNCT dti-1426 223 7 zhang zhang PROPN dti-1426 223 8 l l PROPN dti-1426 223 9 , , PUNCT dti-1426 223 10 et et PROPN dti-1426 223 11 al al PROPN dti-1426 223 12 . . PROPN dti-1426 223 13 hierarchical hierarchical ADJ dti-1426 223 14 assembly assembly NOUN dti-1426 223 15 of of ADP dti-1426 223 16 nanostructured nanostructure VERB dti-1426 223 17 organosilicate organosilicate ADJ dti-1426 223 18 networks network NOUN dti-1426 223 19 via via ADP dti-1426 223 20 stereocomplexation stereocomplexation NOUN dti-1426 223 21 of of ADP dti-1426 223 22 block block NOUN dti-1426 223 23 copolymers copolymer NOUN dti-1426 223 24 . . PUNCT dti-1426 224 1 nano nano PROPN dti-1426 224 2 lett lett PROPN dti-1426 224 3 . . PUNCT dti-1426 225 1 2008;8(1):294–301 2008;8(1):294–301 NUM dti-1426 225 2 . . PROPN dti-1426 225 3 20 20 NUM dti-1426 225 4 . . PUNCT dti-1426 226 1 centola centola PROPN dti-1426 226 2 m m PROPN dti-1426 226 3 , , PUNCT dti-1426 226 4 rainer rainer VERB dti-1426 226 5 a a DET dti-1426 226 6 , , PUNCT dti-1426 226 7 spadaccio spadaccio NOUN dti-1426 226 8 c c NOUN dti-1426 226 9 , , PUNCT dti-1426 226 10 et et PROPN dti-1426 226 11 al al PROPN dti-1426 226 12 . . PUNCT dti-1426 227 1 combining combine VERB dti-1426 227 2 electrospinning electrospinne VERB dti-1426 227 3 and and CCONJ dti-1426 227 4 fused fused ADJ dti-1426 227 5 deposition deposition NOUN dti-1426 227 6 modeling modeling NOUN dti-1426 227 7 for for ADP dti-1426 227 8 the the DET dti-1426 227 9 fabrication fabrication NOUN dti-1426 227 10 of of ADP dti-1426 227 11 a a DET dti-1426 227 12 hybrid hybrid ADJ dti-1426 227 13 vascular vascular NOUN dti-1426 227 14 graft graft NOUN dti-1426 227 15 . . PUNCT dti-1426 228 1 biofabrication biofabrication NOUN dti-1426 228 2 . . PUNCT dti-1426 229 1 2010;2(1):014102 2010;2(1):014102 NUM dti-1426 229 2 . . PROPN dti-1426 229 3 21 21 NUM dti-1426 229 4 . . X dti-1426 230 1 giannitelli giannitelli PROPN dti-1426 230 2 sm sm PROPN dti-1426 230 3 , , PUNCT dti-1426 230 4 accoto accoto NOUN dti-1426 230 5 d d PROPN dti-1426 230 6 , , PUNCT dti-1426 230 7 trombetta trombetta PROPN dti-1426 230 8 m m PROPN dti-1426 230 9 , , PUNCT dti-1426 230 10 et et PROPN dti-1426 230 11 al al PROPN dti-1426 230 12 . . PUNCT dti-1426 231 1 current current ADJ dti-1426 231 2 trends trend NOUN dti-1426 231 3 in in ADP dti-1426 231 4 the the DET dti-1426 231 5 design design NOUN dti-1426 231 6 of of ADP dti-1426 231 7 scaffolds scaffold NOUN dti-1426 231 8 for for ADP dti-1426 231 9 computer computer NOUN dti-1426 231 10 - - PUNCT dti-1426 231 11 aided aid VERB dti-1426 231 12 tissue tissue NOUN dti-1426 231 13 engineering engineering NOUN dti-1426 231 14 . . PUNCT dti-1426 232 1 acta acta PROPN dti-1426 232 2 biomater biomater PROPN dti-1426 232 3 . . PUNCT dti-1426 233 1 2014;10(2 2014;10(2 NUM dti-1426 233 2 ): ): PUNCT dti-1426 234 1 580–594 580–594 NUM dti-1426 234 2 . . PUNCT dti-1426 235 1 22 22 NUM dti-1426 235 2 . . PUNCT dti-1426 236 1 giannitelli giannitelli PROPN dti-1426 236 2 sm sm PROPN dti-1426 236 3 , , PUNCT dti-1426 236 4 mozetic mozetic ADJ dti-1426 236 5 p p NOUN dti-1426 236 6 , , PUNCT dti-1426 236 7 trombetta trombetta NOUN dti-1426 236 8 m m PROPN dti-1426 236 9 , , PUNCT dti-1426 236 10 et et PROPN dti-1426 236 11 al al PROPN dti-1426 236 12 . . PROPN dti-1426 237 1 combined combine VERB dti-1426 237 2 additive additive ADJ dti-1426 237 3 manufacturing manufacturing NOUN dti-1426 237 4 approaches approach NOUN dti-1426 237 5 in in ADP dti-1426 237 6 tissue tissue NOUN dti-1426 237 7 engineering engineering NOUN dti-1426 237 8 . . PUNCT dti-1426 238 1 acta acta PROPN dti-1426 238 2 biomater biomater PROPN dti-1426 238 3 . . PUNCT dti-1426 239 1 2015;24:1–11 2015;24:1–11 NOUN dti-1426 239 2 . . PUNCT dti-1426 240 1 23 23 NUM dti-1426 240 2 . . PUNCT dti-1426 241 1 lobo lobo PROPN dti-1426 241 2 bl bl PROPN dti-1426 241 3 , , PUNCT dti-1426 241 4 greene greene PROPN dti-1426 241 5 wl wl PROPN dti-1426 241 6 . . PUNCT dti-1426 242 1 accp accp PROPN dti-1426 242 2 consensus consensus NOUN dti-1426 242 3 conference conference NOUN dti-1426 242 4 on on ADP dti-1426 242 5 antithrombotic antithrombotic ADJ dti-1426 242 6 therapy therapy NOUN dti-1426 242 7 . . PUNCT dti-1426 243 1 indicate indicate VERB dti-1426 243 2 specific specific ADJ dti-1426 243 3 low low ADJ dti-1426 243 4 molecular molecular ADJ dti-1426 243 5 weight weight NOUN dti-1426 243 6 heparin heparin NOUN dti-1426 243 7 product product NOUN dti-1426 243 8 and and CCONJ dti-1426 243 9 dosage dosage NOUN dti-1426 243 10 . . PUNCT dti-1426 244 1 chest chest NOUN dti-1426 244 2 . . PUNCT dti-1426 245 1 1996;110(3):866 1996;110(3):866 NUM dti-1426 245 2 . . PUNCT dti-1426 246 1 24 24 NUM dti-1426 246 2 . . PUNCT dti-1426 247 1 tillman tillman NOUN dti-1426 247 2 bw bw PROPN dti-1426 247 3 , , PUNCT dti-1426 247 4 yazdani yazdani PROPN dti-1426 247 5 sk sk PROPN dti-1426 247 6 , , PUNCT dti-1426 247 7 lee lee PROPN dti-1426 247 8 sj sj PROPN dti-1426 247 9 , , PUNCT dti-1426 247 10 et et PROPN dti-1426 247 11 al al PROPN dti-1426 247 12 . . PUNCT dti-1426 248 1 the the DET dti-1426 248 2 in in ADP dti-1426 248 3 vivo vivo ADJ dti-1426 248 4 stability stability NOUN dti-1426 248 5 of of ADP dti-1426 248 6 electrospun electrospun NOUN dti-1426 248 7 polycaprolactone polycaprolactone NOUN dti-1426 248 8 - - PUNCT dti-1426 248 9 collagen collagen NOUN dti-1426 248 10 scaffolds scaffold NOUN dti-1426 248 11 in in ADP dti-1426 248 12 vascular vascular ADJ dti-1426 248 13 reconstruction reconstruction NOUN dti-1426 248 14 . . PUNCT dti-1426 248 15 biomaterials biomaterial NOUN dti-1426 248 16 . . PUNCT dti-1426 249 1 2009;30(4):583–588 2009;30(4):583–588 X dti-1426 249 2 . . PUNCT dti-1426 250 1 25 25 NUM dti-1426 250 2 . . X dti-1426 250 3 de de PROPN dti-1426 250 4 mulder mulder PROPN dti-1426 250 5 pa pa PROPN dti-1426 250 6 , , PUNCT dti-1426 250 7 van van PROPN dti-1426 250 8 kerckhoven kerckhoven PROPN dti-1426 250 9 rj rj PROPN dti-1426 250 10 , , PUNCT dti-1426 250 11 adriaensen adriaensen PROPN dti-1426 250 12 hf hf PROPN dti-1426 250 13 , , PUNCT dti-1426 250 14 et et PROPN dti-1426 250 15 al al PROPN dti-1426 250 16 . . PUNCT dti-1426 251 1 continuous continuous ADJ dti-1426 251 2 total total ADJ dti-1426 251 3 intravenous intravenous ADJ dti-1426 251 4 anesthesia anesthesia NOUN dti-1426 251 5 , , PUNCT dti-1426 251 6 using use VERB dti-1426 251 7 propofol propofol NOUN dti-1426 251 8 and and CCONJ dti-1426 251 9 fentanyl fentanyl NOUN dti-1426 251 10 in in ADP dti-1426 251 11 an an DET dti-1426 251 12 open open ADJ dti-1426 251 13 - - PUNCT dti-1426 251 14 thorax thorax NOUN dti-1426 251 15 rabbit rabbit NOUN dti-1426 251 16 model model NOUN dti-1426 251 17 : : PUNCT dti-1426 251 18 evaluation evaluation NOUN dti-1426 251 19 of of ADP dti-1426 251 20 cardiac cardiac ADJ dti-1426 251 21 contractile contractile NOUN dti-1426 251 22 function function NOUN dti-1426 251 23 and and CCONJ dti-1426 251 24 biochemical biochemical ADJ dti-1426 251 25 assessment assessment NOUN dti-1426 251 26 . . PUNCT dti-1426 252 1 lab lab PROPN dti-1426 252 2 anim anim PROPN dti-1426 252 3 sci sci PROPN dti-1426 252 4 . . PUNCT dti-1426 253 1 1997;47(4):367–375 1997;47(4):367–375 NUM dti-1426 253 2 . . PUNCT dti-1426 253 3 http://www.la-press.com http://www.la-press.com X dti-1426 254 1 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN dti-1426 254 2 hybrid hybrid ADJ dti-1426 254 3 armored armored ADJ dti-1426 254 4 vascular vascular ADJ dti-1426 254 5 graft graft NOUN dti-1426 254 6 manufacturing manufacturing NOUN dti-1426 254 7 techniques technique NOUN dti-1426 254 8 7drug 7drug NUM dti-1426 254 9 target target NOUN dti-1426 254 10 insights insight NOUN dti-1426 254 11 2016:10(s1 2016:10(s1 NUM dti-1426 254 12 ) ) PUNCT dti-1426 254 13 26 26 NUM dti-1426 254 14 . . PUNCT dti-1426 255 1 isenberg isenberg PROPN dti-1426 255 2 bc bc PROPN dti-1426 255 3 , , PUNCT dti-1426 255 4 williams williams PROPN dti-1426 255 5 c c PROPN dti-1426 255 6 , , PUNCT dti-1426 255 7 tranquillo tranquillo PROPN dti-1426 255 8 rt rt PROPN dti-1426 255 9 . . PUNCT dti-1426 255 10 small small ADJ dti-1426 255 11 - - PUNCT dti-1426 255 12 diameter diameter NOUN dti-1426 255 13 artificial artificial ADJ dti-1426 255 14 arteries artery NOUN dti-1426 255 15 engineered engineer VERB dti-1426 255 16 in in ADP dti-1426 255 17 vitro vitro X dti-1426 255 18 . . PUNCT dti-1426 256 1 circ circ PROPN dti-1426 256 2 res re NOUN dti-1426 256 3 . . PUNCT dti-1426 257 1 2006;98(1):25–35 2006;98(1):25–35 NUM dti-1426 257 2 . . NOUN dti-1426 257 3 27 27 NUM dti-1426 257 4 . . PUNCT dti-1426 258 1 l’heureux l’heureux PROPN dti-1426 258 2 n n CCONJ dti-1426 258 3 , , PUNCT dti-1426 258 4 dusserre dusserre NOUN dti-1426 258 5 n n CCONJ dti-1426 258 6 , , PUNCT dti-1426 258 7 marini marini PROPN dti-1426 258 8 a a PROPN dti-1426 258 9 , , PUNCT dti-1426 258 10 et et PROPN dti-1426 258 11 al al PROPN dti-1426 258 12 . . PUNCT dti-1426 258 13 technology technology PROPN dti-1426 258 14 insight insight NOUN dti-1426 258 15 : : PUNCT dti-1426 258 16 the the DET dti-1426 258 17 evolution evolution NOUN dti-1426 258 18 of of ADP dti-1426 258 19 tissue tissue NOUN dti-1426 258 20 - - PUNCT dti-1426 258 21 engineered engineer VERB dti-1426 258 22 vascular vascular ADJ dti-1426 258 23 grafts graft NOUN dti-1426 258 24 — — PUNCT dti-1426 258 25 from from ADP dti-1426 258 26 research research NOUN dti-1426 258 27 to to ADP dti-1426 258 28 clinical clinical ADJ dti-1426 258 29 practice practice NOUN dti-1426 258 30 . . PUNCT dti-1426 259 1 nat nat PROPN dti-1426 259 2 clin clin PROPN dti-1426 259 3 pract pract PROPN dti-1426 259 4 cardiovasc cardiovasc PROPN dti-1426 259 5 med me VERB dti-1426 259 6 . . PUNCT dti-1426 260 1 2007;4(7):389–395 2007;4(7):389–395 X dti-1426 260 2 . . NOUN dti-1426 260 3 28 28 NUM dti-1426 260 4 . . PUNCT dti-1426 260 5 stegemann stegemann PROPN dti-1426 260 6 jp jp PROPN dti-1426 260 7 , , PUNCT dti-1426 260 8 kaszuba kaszuba PROPN dti-1426 260 9 sn sn PROPN dti-1426 260 10 , , PUNCT dti-1426 260 11 rowe rowe PROPN dti-1426 260 12 sl sl PROPN dti-1426 260 13 . . PROPN dti-1426 260 14 review review PROPN dti-1426 260 15 : : PUNCT dti-1426 260 16 advances advance NOUN dti-1426 260 17 in in ADP dti-1426 260 18 vascular vascular ADJ dti-1426 260 19 tissue tissue NOUN dti-1426 260 20 engineering engineering NOUN dti-1426 260 21 using use VERB dti-1426 260 22 protein protein NOUN dti-1426 260 23 - - PUNCT dti-1426 260 24 based base VERB dti-1426 260 25 biomaterials biomaterial NOUN dti-1426 260 26 . . PUNCT dti-1426 261 1 tissue tissue NOUN dti-1426 261 2 eng eng PROPN dti-1426 261 3 . . PROPN dti-1426 262 1 2007;13(11 2007;13(11 NUM dti-1426 262 2 ): ): PUNCT dti-1426 262 3 2601–2613 2601–2613 NUM dti-1426 262 4 . . NOUN dti-1426 263 1 29 29 NUM dti-1426 263 2 . . PUNCT dti-1426 264 1 tetik tetik ADV dti-1426 265 1 o o NOUN dti-1426 265 2 , , PUNCT dti-1426 265 3 islamoglu islamoglu PROPN dti-1426 265 4 f f PROPN dti-1426 265 5 , , PUNCT dti-1426 265 6 goncu goncu PROPN dti-1426 265 7 t t PROPN dti-1426 265 8 , , PUNCT dti-1426 265 9 et et PROPN dti-1426 265 10 al al PROPN dti-1426 265 11 . . PUNCT dti-1426 265 12 reduction reduction NOUN dti-1426 265 13 of of ADP dti-1426 265 14 spinal spinal ADJ dti-1426 265 15 cord cord NOUN dti-1426 265 16 injury injury NOUN dti-1426 265 17 with with ADP dti-1426 265 18 pentobarbital pentobarbital NOUN dti-1426 265 19 and and CCONJ dti-1426 265 20 hypothermia hypothermia NOUN dti-1426 265 21 in in ADP dti-1426 265 22 a a DET dti-1426 265 23 rabbit rabbit NOUN dti-1426 265 24 model model NOUN dti-1426 265 25 . . PUNCT dti-1426 266 1 eur eur PROPN dti-1426 266 2 j j PROPN dti-1426 266 3 vasc vasc PROPN dti-1426 266 4 endovasc endovasc PROPN dti-1426 266 5 surg surg PROPN dti-1426 266 6 . . PUNCT dti-1426 267 1 2002;24(6 2002;24(6 NUM dti-1426 267 2 ): ): PUNCT dti-1426 267 3 540–544 540–544 NUM dti-1426 267 4 . . NOUN dti-1426 267 5 30 30 NUM dti-1426 267 6 . . X dti-1426 268 1 wisselink wisselink VERB dti-1426 268 2 w w PROPN dti-1426 268 3 , , PUNCT dti-1426 268 4 money money PROPN dti-1426 268 5 sr sr PROPN dti-1426 268 6 , , PUNCT dti-1426 268 7 crockett crockett PROPN dti-1426 268 8 de de PROPN dti-1426 268 9 , , PUNCT dti-1426 268 10 et et PROPN dti-1426 268 11 al al PROPN dti-1426 268 12 . . PROPN dti-1426 268 13 ischemia ischemia NOUN dti-1426 268 14 - - PUNCT dti-1426 268 15 reperfusion reperfusion NOUN dti-1426 268 16 injury injury NOUN dti-1426 268 17 of of ADP dti-1426 268 18 the the DET dti-1426 268 19 spinal spinal ADJ dti-1426 268 20 cord cord NOUN dti-1426 268 21 : : PUNCT dti-1426 268 22 protective protective ADJ dti-1426 268 23 effect effect NOUN dti-1426 268 24 of of ADP dti-1426 268 25 the the DET dti-1426 268 26 hydroxyl hydroxyl NOUN dti-1426 268 27 radical radical ADJ dti-1426 268 28 scavenger scavenger NOUN dti-1426 268 29 dimethylthiourea dimethylthiourea NOUN dti-1426 268 30 . . PUNCT dti-1426 269 1 j j PROPN dti-1426 269 2 vasc vasc PROPN dti-1426 269 3 surg surg PROPN dti-1426 269 4 . . PUNCT dti-1426 270 1 1994;20(3):444–491 1994;20(3):444–491 X dti-1426 270 2 . . PUNCT dti-1426 271 1 [ [ X dti-1426 271 2 discussion discussion NOUN dti-1426 271 3 449–450 449–450 NUM dti-1426 271 4 ] ] PUNCT dti-1426 271 5 . . PUNCT dti-1426 272 1 31 31 NUM dti-1426 272 2 . . PUNCT dti-1426 273 1 chandy chandy PROPN dti-1426 273 2 t t PROPN dti-1426 273 3 , , PUNCT dti-1426 273 4 rao rao PROPN dti-1426 273 5 gh gh PROPN dti-1426 273 6 , , PUNCT dti-1426 273 7 wilson wilson PROPN dti-1426 273 8 rf rf PROPN dti-1426 273 9 , , PUNCT dti-1426 273 10 et et PROPN dti-1426 273 11 al al PROPN dti-1426 273 12 . . PUNCT dti-1426 273 13 delivery delivery NOUN dti-1426 273 14 of of ADP dti-1426 273 15 lmw lmw ADJ dti-1426 273 16 heparin heparin NOUN dti-1426 273 17 via via ADP dti-1426 273 18 surface surface NOUN dti-1426 273 19 coated coat VERB dti-1426 273 20 chitosan chitosan NOUN dti-1426 273 21 / / SYM dti-1426 273 22 peg peg NOUN dti-1426 273 23 - - PUNCT dti-1426 273 24 alginate alginate NOUN dti-1426 273 25 microspheres microsphere NOUN dti-1426 273 26 prevents prevent VERB dti-1426 273 27 thrombosis thrombosis NOUN dti-1426 273 28 . . PUNCT dti-1426 274 1 drug drug NOUN dti-1426 274 2 deliv deliv NOUN dti-1426 274 3 . . PUNCT dti-1426 275 1 2002;9(2):87–96 2002;9(2):87–96 NUM dti-1426 275 2 . . X dti-1426 276 1 32 32 NUM dti-1426 276 2 . . PUNCT dti-1426 277 1 philbrick philbrick PROPN dti-1426 277 2 jt jt PROPN dti-1426 277 3 . . PROPN dti-1426 277 4 review review PROPN dti-1426 277 5 : : PUNCT dti-1426 277 6 extended extend VERB dti-1426 277 7 - - PUNCT dti-1426 277 8 duration duration NOUN dti-1426 277 9 prophylaxis prophylaxis NOUN dti-1426 277 10 with with ADP dti-1426 277 11 heparin heparin ADJ dti-1426 277 12 prevents prevent VERB dti-1426 277 13 deep deep ADJ dti-1426 277 14 venous venous ADJ dti-1426 277 15 thrombosis thrombosis NOUN dti-1426 277 16 in in ADP dti-1426 277 17 hip hip NOUN dti-1426 277 18 or or CCONJ dti-1426 277 19 knee knee NOUN dti-1426 277 20 replacement replacement NOUN dti-1426 277 21 . . PUNCT dti-1426 278 1 acp acp PROPN dti-1426 278 2 j j PROPN dti-1426 278 3 club club PROPN dti-1426 278 4 . . PUNCT dti-1426 279 1 2002;136(1):9 2002;136(1):9 NUM dti-1426 279 2 . . PROPN dti-1426 280 1 33 33 NUM dti-1426 280 2 . . PUNCT dti-1426 281 1 chabut chabut NOUN dti-1426 282 1 d d PROPN dti-1426 282 2 , , PUNCT dti-1426 282 3 fischer fischer PROPN dti-1426 282 4 am be AUX dti-1426 282 5 , , PUNCT dti-1426 282 6 colliec colliec NOUN dti-1426 282 7 - - PUNCT dti-1426 282 8 jouault jouault NOUN dti-1426 282 9 s s PROPN dti-1426 282 10 , , PUNCT dti-1426 282 11 et et PROPN dti-1426 282 12 al al PROPN dti-1426 282 13 . . PROPN dti-1426 283 1 low low PROPN dti-1426 283 2 molecular molecular ADJ dti-1426 283 3 weight weight NOUN dti-1426 283 4 fucoidan fucoidan NOUN dti-1426 283 5 and and CCONJ dti-1426 283 6 heparin heparin NOUN dti-1426 283 7 enhance enhance VERB dti-1426 283 8 the the DET dti-1426 283 9 basic basic ADJ dti-1426 283 10 fibroblast fibroblast ADJ dti-1426 283 11 growth growth NOUN dti-1426 283 12 factor factor NOUN dti-1426 283 13 - - PUNCT dti-1426 283 14 induced induce VERB dti-1426 283 15 tube tube NOUN dti-1426 283 16 formation formation NOUN dti-1426 283 17 of of ADP dti-1426 283 18 endothelial endothelial ADJ dti-1426 283 19 cells cell NOUN dti-1426 283 20 through through ADP dti-1426 283 21 heparan heparan ADJ dti-1426 283 22 sulfate sulfate NOUN dti-1426 283 23 - - PUNCT dti-1426 283 24 dependent dependent ADJ dti-1426 283 25 alpha6 alpha6 ADJ dti-1426 283 26 overexpression overexpression NOUN dti-1426 283 27 . . PUNCT dti-1426 284 1 mol mol ADP dti-1426 284 2 pharmacol pharmacol PROPN dti-1426 284 3 . . PUNCT dti-1426 285 1 2003;64(3):696–702 2003;64(3):696–702 NUM dti-1426 285 2 . . PROPN dti-1426 285 3 34 34 NUM dti-1426 285 4 . . PUNCT dti-1426 285 5 serizawa serizawa PROPN dti-1426 285 6 n n CCONJ dti-1426 285 7 , , PUNCT dti-1426 285 8 takei takei PROPN dti-1426 285 9 y y PROPN dti-1426 285 10 , , PUNCT dti-1426 285 11 okubo okubo PROPN dti-1426 285 12 h h PROPN dti-1426 285 13 , , PUNCT dti-1426 285 14 et et PROPN dti-1426 285 15 al al PROPN dti-1426 285 16 . . PROPN dti-1426 285 17 effect effect NOUN dti-1426 285 18 of of ADP dti-1426 285 19 low low ADJ dti-1426 285 20 - - PUNCT dti-1426 285 21 molecular molecular ADJ dti-1426 285 22 - - PUNCT dti-1426 285 23 weight weight NOUN dti-1426 285 24 heparin heparin NOUN dti-1426 285 25 on on ADP dti-1426 285 26 the the DET dti-1426 285 27 commitment commitment NOUN dti-1426 285 28 of of ADP dti-1426 285 29 bone bone NOUN dti-1426 285 30 marrow marrow NOUN dti-1426 285 31 cells cell NOUN dti-1426 285 32 to to PART dti-1426 285 33 liver liver VERB dti-1426 285 34 sinusoidal sinusoidal ADJ dti-1426 285 35 endothelial endothelial ADJ dti-1426 285 36 cells cell NOUN dti-1426 285 37 in in ADP dti-1426 285 38 ccl(4)-induced ccl(4)-induced ADJ dti-1426 285 39 liver liver NOUN dti-1426 285 40 injury injury NOUN dti-1426 285 41 . . PUNCT dti-1426 286 1 hepatol hepatol ADJ dti-1426 286 2 res re NOUN dti-1426 286 3 . . PUNCT dti-1426 287 1 2006;34(4):207–213 2006;34(4):207–213 NUM dti-1426 287 2 . . X dti-1426 287 3 35 35 NUM dti-1426 287 4 . . PUNCT dti-1426 287 5 spadaccio spadaccio PROPN dti-1426 288 1 c c NOUN dti-1426 288 2 , , PUNCT dti-1426 288 3 rainer rainer VERB dti-1426 288 4 a a PRON dti-1426 288 5 , , PUNCT dti-1426 288 6 de de X dti-1426 288 7 porcellinis porcellinis PROPN dti-1426 288 8 s s PART dti-1426 288 9 , , PUNCT dti-1426 288 10 et et PROPN dti-1426 288 11 al al PROPN dti-1426 288 12 . . PUNCT dti-1426 289 1 a a DET dti-1426 289 2 g g NOUN dti-1426 289 3 - - PUNCT dti-1426 289 4 csf csf ADJ dti-1426 289 5 functionalized functionalized ADJ dti-1426 289 6 plla plla NOUN dti-1426 289 7 scaffold scaffold NOUN dti-1426 289 8 for for ADP dti-1426 289 9 wound wound ADJ dti-1426 289 10 repair repair NOUN dti-1426 289 11 : : PUNCT dti-1426 289 12 an an DET dti-1426 289 13 in in ADP dti-1426 289 14 vitro vitro X dti-1426 289 15 preliminary preliminary ADJ dti-1426 289 16 study study NOUN dti-1426 289 17 . . PUNCT dti-1426 290 1 conf conf PROPN dti-1426 290 2 proc proc PROPN dti-1426 290 3 ieee ieee PROPN dti-1426 290 4 eng eng PROPN dti-1426 290 5 med med PROPN dti-1426 290 6 biol biol PROPN dti-1426 290 7 soc soc NOUN dti-1426 290 8 . . PUNCT dti-1426 291 1 2010;2010:843–846 2010;2010:843–846 NUM dti-1426 291 2 . . PUNCT dti-1426 292 1 36 36 NUM dti-1426 292 2 . . PUNCT dti-1426 292 3 spadaccio spadaccio PROPN dti-1426 292 4 c c NOUN dti-1426 292 5 , , PUNCT dti-1426 292 6 rainer rainer VERB dti-1426 292 7 a a PRON dti-1426 292 8 , , PUNCT dti-1426 292 9 trombetta trombetta PROPN dti-1426 292 10 m m PROPN dti-1426 292 11 , , PUNCT dti-1426 292 12 et et PROPN dti-1426 292 13 al al PROPN dti-1426 292 14 . . PUNCT dti-1426 293 1 a a DET dti-1426 293 2 g g NOUN dti-1426 293 3 - - PUNCT dti-1426 293 4 csf csf NOUN dti-1426 293 5 functionalized functionalize VERB dti-1426 293 6 scaffold scaffold NOUN dti-1426 293 7 for for ADP dti-1426 293 8 stem stem NOUN dti-1426 293 9 cells cell NOUN dti-1426 293 10 seeding seed VERB dti-1426 293 11 : : PUNCT dti-1426 293 12 a a DET dti-1426 293 13 differentiating differentiate VERB dti-1426 293 14 device device NOUN dti-1426 293 15 for for ADP dti-1426 293 16 cardiac cardiac ADJ dti-1426 293 17 purposes purpose NOUN dti-1426 293 18 . . PUNCT dti-1426 294 1 j j PROPN dti-1426 294 2 cell cell NOUN dti-1426 294 3 mol mol ADP dti-1426 294 4 med med PROPN dti-1426 294 5 . . PUNCT dti-1426 295 1 2011;15(5):1096–1108 2011;15(5):1096–1108 NUM dti-1426 295 2 . . PUNCT dti-1426 296 1 37 37 NUM dti-1426 296 2 . . PUNCT dti-1426 296 3 spadaccio spadaccio PROPN dti-1426 296 4 c c NOUN dti-1426 296 5 , , PUNCT dti-1426 296 6 rainer rainer VERB dti-1426 296 7 a a PRON dti-1426 296 8 , , PUNCT dti-1426 296 9 trombetta trombetta PROPN dti-1426 296 10 m m PROPN dti-1426 296 11 , , PUNCT dti-1426 296 12 et et PROPN dti-1426 296 13 al al PROPN dti-1426 296 14 . . PUNCT dti-1426 296 15 poly poly ADJ dti-1426 296 16 - - PUNCT dti-1426 296 17 l l NOUN dti-1426 296 18 - - ADJ dti-1426 296 19 lactic lactic ADJ dti-1426 296 20 acid acid NOUN dti-1426 296 21 / / SYM dti-1426 296 22 hydroxyapatite hydroxyapatite NOUN dti-1426 296 23 electrospun electrospun NOUN dti-1426 296 24 nanocomposites nanocomposite NOUN dti-1426 296 25 induce induce VERB dti-1426 296 26 chondrogenic chondrogenic ADJ dti-1426 296 27 differentiation differentiation NOUN dti-1426 296 28 of of ADP dti-1426 296 29 human human PROPN dti-1426 296 30 msc msc PROPN dti-1426 296 31 . . PUNCT dti-1426 297 1 ann ann PROPN dti-1426 297 2 biomed biome VERB dti-1426 297 3 eng eng PROPN dti-1426 297 4 . . PUNCT dti-1426 297 5 2009;37(7):1376–1389 2009;37(7):1376–1389 NUM dti-1426 297 6 . . PUNCT dti-1426 298 1 38 38 NUM dti-1426 298 2 . . PUNCT dti-1426 299 1 rainer rainer PROPN dti-1426 299 2 a a DET dti-1426 299 3 , , PUNCT dti-1426 299 4 spadaccio spadaccio NOUN dti-1426 299 5 c c NOUN dti-1426 299 6 , , PUNCT dti-1426 299 7 sedati sedati PROPN dti-1426 299 8 p p PROPN dti-1426 299 9 , , PUNCT dti-1426 299 10 et et PROPN dti-1426 299 11 al al PROPN dti-1426 299 12 . . PROPN dti-1426 299 13 electrospun electrospun PROPN dti-1426 299 14 hydroxyapatitefunctionalized hydroxyapatitefunctionalize VERB dti-1426 299 15 plla plla NOUN dti-1426 299 16 scaffold scaffold NOUN dti-1426 299 17 : : PUNCT dti-1426 299 18 potential potential ADJ dti-1426 299 19 applications application NOUN dti-1426 299 20 in in ADP dti-1426 299 21 sternal sternal ADJ dti-1426 299 22 bone bone NOUN dti-1426 299 23 healing healing NOUN dti-1426 299 24 . . PUNCT dti-1426 300 1 ann ann PROPN dti-1426 300 2 biomed biome VERB dti-1426 300 3 eng eng PROPN dti-1426 300 4 . . PUNCT dti-1426 300 5 2011;39(7):1882–1890 2011;39(7):1882–1890 PROPN dti-1426 300 6 . . PUNCT dti-1426 301 1 http://www.la-press.com http://www.la-press.com X dti-1426 301 2 http://www.la-press.com/drug-target-insights-journal-j23 http://www.la-press.com/drug-target-insights-journal-j23 PROPN