id	sid	tid	token	lemma	pos
dti-2103	1	1	dti	dti	PROPN
dti-2103	1	2	©	©	PROPN
dti-2103	1	3	2020	2020	NUM
dti-2103	1	4	the	the	DET
dti-2103	1	5	authors	author	NOUN
dti-2103	1	6	.	.	PUNCT
dti-2103	2	1	this	this	DET
dti-2103	2	2	article	article	NOUN
dti-2103	2	3	is	be	AUX
dti-2103	2	4	published	publish	VERB
dti-2103	2	5	by	by	ADP
dti-2103	2	6	aboutscience	aboutscience	NOUN
dti-2103	2	7	and	and	CCONJ
dti-2103	2	8	licensed	license	VERB
dti-2103	2	9	under	under	ADP
dti-2103	2	10	creative	creative	ADJ
dti-2103	2	11	commons	common	NOUN
dti-2103	2	12	attribution	attribution	NOUN
dti-2103	2	13	-	-	PUNCT
dti-2103	2	14	noncommercial	noncommercial	ADJ
dti-2103	2	15	4.0	4.0	NUM
dti-2103	2	16	international	international	NOUN
dti-2103	2	17	(	(	PUNCT
dti-2103	2	18	cc	cc	NOUN
dti-2103	2	19	by	by	ADP
dti-2103	2	20	-	-	PUNCT
dti-2103	2	21	nc	nc	PROPN
dti-2103	2	22	4.0	4.0	NUM
dti-2103	2	23	)	)	PUNCT
dti-2103	2	24	.	.	PUNCT
dti-2103	3	1	any	any	DET
dti-2103	3	2	commercial	commercial	ADJ
dti-2103	3	3	use	use	NOUN
dti-2103	3	4	is	be	AUX
dti-2103	3	5	not	not	PART
dti-2103	3	6	permitted	permit	VERB
dti-2103	3	7	and	and	CCONJ
dti-2103	3	8	is	be	AUX
dti-2103	3	9	subject	subject	ADJ
dti-2103	3	10	to	to	ADP
dti-2103	3	11	publisher	publisher	NOUN
dti-2103	3	12	’s	’s	PART
dti-2103	3	13	permissions	permission	NOUN
dti-2103	3	14	.	.	PUNCT
dti-2103	4	1	full	full	ADJ
dti-2103	4	2	information	information	NOUN
dti-2103	4	3	is	be	AUX
dti-2103	4	4	available	available	ADJ
dti-2103	4	5	at	at	ADP
dti-2103	4	6	www.aboutscience.eu	www.aboutscience.eu	PROPN
dti-2103	4	7	issn	issn	PROPN
dti-2103	4	8	1177	1177	NUM
dti-2103	4	9	-	-	SYM
dti-2103	4	10	3928	3928	NUM
dti-2103	4	11	drug	drug	NOUN
dti-2103	4	12	target	target	NOUN
dti-2103	4	13	insights	insight	NOUN
dti-2103	4	14	2020	2020	NUM
dti-2103	4	15	;	;	PUNCT
dti-2103	4	16	14	14	NUM
dti-2103	4	17	:	:	SYM
dti-2103	4	18	26	26	NUM
dti-2103	4	19	-	-	SYM
dti-2103	4	20	33	33	NUM
dti-2103	4	21	original	original	ADJ
dti-2103	4	22	research	research	NOUN
dti-2103	4	23	article	article	NOUN
dti-2103	4	24	doi	doi	NOUN
dti-2103	4	25	:	:	PUNCT
dti-2103	4	26	10.33393	10.33393	NUM
dti-2103	4	27	/	/	SYM
dti-2103	4	28	dti.2020.2103	dti.2020.2103	NUM
dti-2103	4	29	targeting	target	VERB
dti-2103	4	30	streptococcus	streptococcus	NOUN
dti-2103	4	31	pneumoniae	pneumoniae	ADP
dti-2103	4	32	udp	udp	NOUN
dti-2103	4	33	-	-	NOUN
dti-2103	4	34	glucose	glucose	NOUN
dti-2103	4	35	pyrophosphorylase	pyrophosphorylase	NOUN
dti-2103	4	36	(	(	PUNCT
dti-2103	4	37	ugpase	ugpase	NOUN
dti-2103	4	38	):	):	PUNCT
dti-2103	4	39	in	in	ADP
dti-2103	4	40	vitro	vitro	X
dti-2103	4	41	validation	validation	NOUN
dti-2103	4	42	of	of	ADP
dti-2103	4	43	a	a	DET
dti-2103	4	44	putative	putative	ADJ
dti-2103	4	45	inhibitor	inhibitor	NOUN
dti-2103	4	46	monica	monica	PROPN
dti-2103	4	47	sharma1	sharma1	PROPN
dti-2103	4	48	,	,	PUNCT
dti-2103	4	49	swati	swati	PROPN
dti-2103	4	50	sharma1	sharma1	PROPN
dti-2103	4	51	,	,	PUNCT
dti-2103	4	52	pallab	pallab	PROPN
dti-2103	4	53	ray2	ray2	NOUN
dti-2103	4	54	,	,	PUNCT
dti-2103	4	55	anuradha	anuradha	PROPN
dti-2103	4	56	chakraborti1	chakraborti1	PROPN
dti-2103	4	57	1molecular	1molecular	NUM
dti-2103	4	58	genetics	genetic	NOUN
dti-2103	4	59	laboratory	laboratory	NOUN
dti-2103	4	60	,	,	PUNCT
dti-2103	4	61	department	department	NOUN
dti-2103	4	62	of	of	ADP
dti-2103	4	63	experimental	experimental	ADJ
dti-2103	4	64	medicine	medicine	NOUN
dti-2103	4	65	and	and	CCONJ
dti-2103	4	66	biotechnology	biotechnology	NOUN
dti-2103	4	67	,	,	PUNCT
dti-2103	4	68	postgraduate	postgraduate	PROPN
dti-2103	4	69	institute	institute	PROPN
dti-2103	4	70	of	of	ADP
dti-2103	4	71	medical	medical	ADJ
dti-2103	4	72	education	education	PROPN
dti-2103	4	73	&	&	CCONJ
dti-2103	4	74	research	research	PROPN
dti-2103	4	75	(	(	PUNCT
dti-2103	4	76	pgimer	pgimer	NOUN
dti-2103	4	77	)	)	PUNCT
dti-2103	4	78	,	,	PUNCT
dti-2103	4	79	chandigarh	chandigarh	PROPN
dti-2103	4	80	india	india	PROPN
dti-2103	4	81	2bacteriology	2bacteriology	PROPN
dti-2103	4	82	laboratory	laboratory	NOUN
dti-2103	4	83	,	,	PUNCT
dti-2103	4	84	department	department	NOUN
dti-2103	4	85	of	of	ADP
dti-2103	4	86	medical	medical	ADJ
dti-2103	4	87	microbiology	microbiology	NOUN
dti-2103	4	88	,	,	PUNCT
dti-2103	4	89	postgraduate	postgraduate	PROPN
dti-2103	4	90	institute	institute	PROPN
dti-2103	4	91	of	of	ADP
dti-2103	4	92	medical	medical	ADJ
dti-2103	4	93	education	education	PROPN
dti-2103	4	94	&	&	CCONJ
dti-2103	4	95	research	research	PROPN
dti-2103	4	96	(	(	PUNCT
dti-2103	4	97	pgimer	pgimer	NOUN
dti-2103	4	98	)	)	PUNCT
dti-2103	4	99	,	,	PUNCT
dti-2103	4	100	chandigarh	chandigarh	PROPN
dti-2103	4	101	india	india	PROPN
dti-2103	4	102	abstract	abstract	ADJ
dti-2103	4	103	background	background	NOUN
dti-2103	4	104	:	:	PUNCT
dti-2103	4	105	genome	genome	NOUN
dti-2103	4	106	plasticity	plasticity	NOUN
dti-2103	4	107	of	of	ADP
dti-2103	4	108	streptococcus	streptococcus	NOUN
dti-2103	4	109	pneumoniae	pneumoniae	ADJ
dti-2103	4	110	is	be	AUX
dti-2103	4	111	responsible	responsible	ADJ
dti-2103	4	112	for	for	ADP
dti-2103	4	113	the	the	DET
dti-2103	4	114	reduced	reduce	VERB
dti-2103	4	115	efficacy	efficacy	NOUN
dti-2103	4	116	of	of	ADP
dti-2103	4	117	various	various	ADJ
dti-2103	4	118	antibiotics	antibiotic	NOUN
dti-2103	4	119	and	and	CCONJ
dti-2103	4	120	capsular	capsular	VERB
dti-2103	4	121	polysaccharide	polysaccharide	NOUN
dti-2103	4	122	-	-	PUNCT
dti-2103	4	123	based	base	VERB
dti-2103	4	124	vaccines	vaccine	NOUN
dti-2103	4	125	.	.	PUNCT
dti-2103	5	1	therefore	therefore	ADV
dti-2103	5	2	,	,	PUNCT
dti-2103	5	3	targets	target	VERB
dti-2103	5	4	independent	independent	ADJ
dti-2103	5	5	of	of	ADP
dti-2103	5	6	capsular	capsular	ADJ
dti-2103	5	7	types	type	NOUN
dti-2103	5	8	are	be	AUX
dti-2103	5	9	sought	seek	VERB
dti-2103	5	10	to	to	PART
dti-2103	5	11	control	control	VERB
dti-2103	5	12	the	the	DET
dti-2103	5	13	pneumococcal	pneumococcal	ADJ
dti-2103	5	14	pathogenicity	pathogenicity	NOUN
dti-2103	5	15	.	.	PUNCT
dti-2103	6	1	udp	udp	NOUN
dti-2103	6	2	-	-	NOUN
dti-2103	6	3	glucose	glucose	NOUN
dti-2103	6	4	pyrophosphorylase	pyrophosphorylase	NOUN
dti-2103	6	5	(	(	PUNCT
dti-2103	6	6	ugpase	ugpase	NOUN
dti-2103	6	7	)	)	PUNCT
dti-2103	6	8	is	be	AUX
dti-2103	6	9	one	one	NUM
dti-2103	6	10	such	such	ADJ
dti-2103	6	11	desired	desire	VERB
dti-2103	6	12	candidate	candidate	NOUN
dti-2103	6	13	being	be	AUX
dti-2103	6	14	responsible	responsible	ADJ
dti-2103	6	15	for	for	ADP
dti-2103	6	16	the	the	DET
dti-2103	6	17	synthesis	synthesis	NOUN
dti-2103	6	18	of	of	ADP
dti-2103	6	19	udp	udp	NOUN
dti-2103	6	20	-	-	NOUN
dti-2103	6	21	glucose	glucose	NOUN
dti-2103	6	22	,	,	PUNCT
dti-2103	6	23	a	a	DET
dti-2103	6	24	sugar	sugar	NOUN
dti-2103	6	25	precursor	precursor	NOUN
dti-2103	6	26	in	in	ADP
dti-2103	6	27	capsular	capsular	NOUN
dti-2103	6	28	biosynthesis	biosynthesis	NOUN
dti-2103	6	29	and	and	CCONJ
dti-2103	6	30	metabolic	metabolic	NOUN
dti-2103	6	31	leloir	leloir	NOUN
dti-2103	6	32	pathway	pathway	NOUN
dti-2103	6	33	.	.	PUNCT
dti-2103	7	1	being	be	AUX
dti-2103	7	2	crucial	crucial	ADJ
dti-2103	7	3	to	to	ADP
dti-2103	7	4	pneumococcal	pneumococcal	ADJ
dti-2103	7	5	pathobiology	pathobiology	NOUN
dti-2103	7	6	,	,	PUNCT
dti-2103	7	7	the	the	DET
dti-2103	7	8	effect	effect	NOUN
dti-2103	7	9	of	of	ADP
dti-2103	7	10	ugpase	ugpase	NOUN
dti-2103	7	11	inhibition	inhibition	NOUN
dti-2103	7	12	on	on	ADP
dti-2103	7	13	virulence	virulence	NOUN
dti-2103	7	14	was	be	AUX
dti-2103	7	15	evaluated	evaluate	VERB
dti-2103	7	16	in	in	ADP
dti-2103	7	17	vitro	vitro	X
dti-2103	7	18	.	.	PUNCT
dti-2103	8	1	methods	method	NOUN
dti-2103	8	2	:	:	PUNCT
dti-2103	8	3	a	a	DET
dti-2103	8	4	putative	putative	ADJ
dti-2103	8	5	inhibitor	inhibitor	NOUN
dti-2103	8	6	,	,	PUNCT
dti-2103	8	7	uridine	uridine	NOUN
dti-2103	8	8	diphosphate	diphosphate	NOUN
dti-2103	8	9	(	(	PUNCT
dti-2103	8	10	udp	udp	PROPN
dti-2103	8	11	)	)	PUNCT
dti-2103	8	12	,	,	PUNCT
dti-2103	8	13	was	be	AUX
dti-2103	8	14	evaluated	evaluate	VERB
dti-2103	8	15	for	for	ADP
dti-2103	8	16	effective	effective	ADJ
dti-2103	8	17	inhibitory	inhibitory	ADJ
dti-2103	8	18	concentration	concentration	NOUN
dti-2103	8	19	in	in	ADP
dti-2103	8	20	s.	s.	PROPN
dti-2103	8	21	pneumoniae	pneumoniae	NOUN
dti-2103	8	22	and	and	CCONJ
dti-2103	8	23	a549	a549	PROPN
dti-2103	8	24	cells	cell	NOUN
dti-2103	8	25	,	,	PUNCT
dti-2103	8	26	its	its	PRON
dti-2103	8	27	efficacy	efficacy	NOUN
dti-2103	8	28	and	and	CCONJ
dti-2103	8	29	toxicity	toxicity	NOUN
dti-2103	8	30	.	.	PUNCT
dti-2103	9	1	the	the	DET
dti-2103	9	2	effect	effect	NOUN
dti-2103	9	3	of	of	ADP
dti-2103	9	4	udp	udp	NOUN
dti-2103	9	5	on	on	ADP
dti-2103	9	6	adherence	adherence	NOUN
dti-2103	9	7	and	and	CCONJ
dti-2103	9	8	phagocytosis	phagocytosis	NOUN
dti-2103	9	9	was	be	AUX
dti-2103	9	10	measured	measure	VERB
dti-2103	9	11	in	in	ADP
dti-2103	9	12	human	human	ADJ
dti-2103	9	13	respiratory	respiratory	ADJ
dti-2103	9	14	epithelial	epithelial	NOUN
dti-2103	9	15	(	(	PUNCT
dti-2103	9	16	a549	a549	PROPN
dti-2103	9	17	and	and	CCONJ
dti-2103	9	18	hep-2	hep-2	PUNCT
dti-2103	9	19	)	)	PUNCT
dti-2103	9	20	and	and	CCONJ
dti-2103	9	21	macrophage	macrophage	ADJ
dti-2103	9	22	(	(	PUNCT
dti-2103	9	23	thp1	thp1	NOUN
dti-2103	9	24	and	and	CCONJ
dti-2103	9	25	j774.a.1	j774.a.1	PROPN
dti-2103	9	26	)	)	PUNCT
dti-2103	9	27	cell	cell	NOUN
dti-2103	9	28	lines	line	NOUN
dti-2103	9	29	respectively	respectively	ADV
dti-2103	9	30	.	.	PUNCT
dti-2103	10	1	results	result	NOUN
dti-2103	10	2	:	:	PUNCT
dti-2103	10	3	a	a	DET
dti-2103	10	4	differential	differential	ADJ
dti-2103	10	5	effective	effective	ADJ
dti-2103	10	6	inhibitory	inhibitory	ADJ
dti-2103	10	7	concentration	concentration	NOUN
dti-2103	10	8	of	of	ADP
dti-2103	10	9	udp	udp	NOUN
dti-2103	10	10	for	for	ADP
dti-2103	10	11	ugpase	ugpase	NOUN
dti-2103	10	12	inhibition	inhibition	NOUN
dti-2103	10	13	was	be	AUX
dti-2103	10	14	observed	observe	VERB
dti-2103	10	15	in	in	ADP
dti-2103	10	16	s.	s.	PROPN
dti-2103	10	17	pneumoniae	pneumoniae	NOUN
dti-2103	10	18	and	and	CCONJ
dti-2103	10	19	a549	a549	PROPN
dti-2103	10	20	cells	cell	NOUN
dti-2103	10	21	,	,	PUNCT
dti-2103	10	22	that	that	ADV
dti-2103	10	23	is	is	ADV
dti-2103	10	24	,	,	PUNCT
dti-2103	10	25	5	5	NUM
dti-2103	10	26	and	and	CCONJ
dti-2103	10	27	100	100	NUM
dti-2103	10	28	µm	µm	ADP
dti-2103	10	29	respectively	respectively	ADV
dti-2103	10	30	.	.	PUNCT
dti-2103	11	1	udp	udp	NOUN
dti-2103	11	2	treatments	treatment	NOUN
dti-2103	11	3	lowered	lower	VERB
dti-2103	11	4	percent	percent	NOUN
dti-2103	11	5	cytotoxicity	cytotoxicity	NOUN
dti-2103	11	6	in	in	ADP
dti-2103	11	7	pneumococcal	pneumococcal	ADJ
dti-2103	11	8	-	-	PUNCT
dti-2103	11	9	infected	infect	VERB
dti-2103	11	10	monolayers	monolayer	NOUN
dti-2103	11	11	and	and	CCONJ
dti-2103	11	12	did	do	AUX
dti-2103	11	13	n’t	not	PART
dti-2103	11	14	exert	exert	VERB
dti-2103	11	15	adverse	adverse	ADJ
dti-2103	11	16	effects	effect	NOUN
dti-2103	11	17	on	on	ADP
dti-2103	11	18	viabilities	viability	NOUN
dti-2103	11	19	.	.	PUNCT
dti-2103	12	1	s.	s.	PROPN
dti-2103	12	2	pneumoniae	pneumoniae	ADJ
dti-2103	12	3	adherence	adherence	NOUN
dti-2103	12	4	to	to	ADP
dti-2103	12	5	host	host	NOUN
dti-2103	12	6	cells	cell	NOUN
dti-2103	12	7	decreased	decrease	VERB
dti-2103	12	8	significantly	significantly	ADV
dti-2103	12	9	with	with	ADP
dti-2103	12	10	udp	udp	NOUN
dti-2103	12	11	treatments	treatment	NOUN
dti-2103	12	12	.	.	PUNCT
dti-2103	13	1	udp	udp	PROPN
dti-2103	13	2	induced	induce	VERB
dti-2103	13	3	the	the	DET
dti-2103	13	4	secretion	secretion	NOUN
dti-2103	13	5	of	of	ADP
dti-2103	13	6	interleukin	interleukin	NOUN
dti-2103	13	7	(	(	PUNCT
dti-2103	13	8	il)-1β	il)-1β	PROPN
dti-2103	13	9	,	,	PUNCT
dti-2103	13	10	tumor	tumor	NOUN
dti-2103	13	11	necrosis	necrosis	NOUN
dti-2103	13	12	factor	factor	NOUN
dti-2103	13	13	(	(	PUNCT
dti-2103	13	14	tnf)-α	tnf)-α	PROPN
dti-2103	13	15	,	,	PUNCT
dti-2103	13	16	il-6	il-6	NOUN
dti-2103	13	17	,	,	PUNCT
dti-2103	13	18	and	and	CCONJ
dti-2103	13	19	il-8	il-8	NOUN
dti-2103	13	20	and	and	CCONJ
dti-2103	13	21	increased	increase	VERB
dti-2103	13	22	pneumococcal	pneumococcal	ADJ
dti-2103	13	23	phagocytosis	phagocytosis	NOUN
dti-2103	13	24	.	.	PUNCT
dti-2103	14	1	conclusion	conclusion	NOUN
dti-2103	14	2	:	:	PUNCT
dti-2103	14	3	our	our	PRON
dti-2103	14	4	study	study	NOUN
dti-2103	14	5	shows	show	VERB
dti-2103	14	6	udp	udp	NOUN
dti-2103	14	7	-	-	ADJ
dti-2103	14	8	mediated	mediate	VERB
dti-2103	14	9	decrease	decrease	NOUN
dti-2103	14	10	in	in	ADP
dti-2103	14	11	the	the	DET
dti-2103	14	12	virulence	virulence	NOUN
dti-2103	14	13	of	of	ADP
dti-2103	14	14	s.	s.	PROPN
dti-2103	14	15	pneumoniae	pneumoniae	PROPN
dti-2103	14	16	and	and	CCONJ
dti-2103	14	17	demonstrates	demonstrate	VERB
dti-2103	14	18	udp	udp	NOUN
dti-2103	14	19	as	as	ADP
dti-2103	14	20	an	an	DET
dti-2103	14	21	effective	effective	ADJ
dti-2103	14	22	inhibitor	inhibitor	NOUN
dti-2103	14	23	of	of	ADP
dti-2103	14	24	pneumococcal	pneumococcal	ADJ
dti-2103	14	25	ugpase	ugpase	NOUN
dti-2103	14	26	.	.	PUNCT
dti-2103	15	1	keywords	keyword	NOUN
dti-2103	15	2	:	:	PUNCT
dti-2103	15	3	capsule	capsule	NOUN
dti-2103	15	4	,	,	PUNCT
dti-2103	15	5	galu	galu	NOUN
dti-2103	15	6	,	,	PUNCT
dti-2103	15	7	inhibitor	inhibitor	NOUN
dti-2103	15	8	,	,	PUNCT
dti-2103	15	9	pneumococcus	pneumococcus	NOUN
dti-2103	15	10	,	,	PUNCT
dti-2103	15	11	udp	udp	PROPN
dti-2103	15	12	,	,	PUNCT
dti-2103	15	13	virulence	virulence	NOUN
dti-2103	15	14	received	receive	VERB
dti-2103	15	15	:	:	PUNCT
dti-2103	15	16	february	february	PROPN
dti-2103	15	17	26	26	NUM
dti-2103	15	18	,	,	PUNCT
dti-2103	15	19	2020	2020	NUM
dti-2103	15	20	accepted	accept	VERB
dti-2103	15	21	:	:	PUNCT
dti-2103	15	22	july	july	PROPN
dti-2103	15	23	30	30	NUM
dti-2103	15	24	,	,	PUNCT
dti-2103	15	25	2020	2020	NUM
dti-2103	15	26	published	publish	VERB
dti-2103	15	27	online	online	ADV
dti-2103	15	28	:	:	PUNCT
dti-2103	15	29	october	october	PROPN
dti-2103	15	30	7	7	NUM
dti-2103	15	31	,	,	PUNCT
dti-2103	15	32	2020	2020	NUM
dti-2103	15	33	corresponding	correspond	VERB
dti-2103	15	34	author	author	NOUN
dti-2103	15	35	:	:	PUNCT
dti-2103	15	36	prof	prof	PROPN
dti-2103	15	37	.	.	PUNCT
dti-2103	16	1	anuradha	anuradha	PROPN
dti-2103	16	2	chakraborti	chakraborti	PROPN
dti-2103	16	3	department	department	PROPN
dti-2103	16	4	of	of	ADP
dti-2103	16	5	experimental	experimental	ADJ
dti-2103	16	6	medicine	medicine	NOUN
dti-2103	16	7	and	and	CCONJ
dti-2103	16	8	biotechnology	biotechnology	NOUN
dti-2103	16	9	postgraduate	postgraduate	PROPN
dti-2103	16	10	institute	institute	PROPN
dti-2103	16	11	of	of	ADP
dti-2103	16	12	medical	medical	ADJ
dti-2103	16	13	education	education	PROPN
dti-2103	16	14	&	&	CCONJ
dti-2103	16	15	research	research	PROPN
dti-2103	16	16	(	(	PUNCT
dti-2103	16	17	pgimer	pgimer	NOUN
dti-2103	16	18	)	)	PUNCT
dti-2103	16	19	chandigarh-160012	chandigarh-160012	NOUN
dti-2103	16	20	,	,	PUNCT
dti-2103	16	21	india	india	PROPN
dti-2103	16	22	superoxide14@gmail.com	superoxide14@gmail.com	PROPN
dti-2103	16	23	and	and	CCONJ
dti-2103	16	24	non	non	ADJ
dti-2103	16	25	-	-	NOUN
dti-2103	16	26	ipds	ipd	NOUN
dti-2103	16	27	,	,	PUNCT
dti-2103	16	28	for	for	ADP
dti-2103	16	29	example	example	NOUN
dti-2103	16	30	,	,	PUNCT
dti-2103	16	31	acute	acute	ADJ
dti-2103	16	32	otitis	otitis	NOUN
dti-2103	16	33	media	medium	NOUN
dti-2103	16	34	and	and	CCONJ
dti-2103	16	35	sinusitis	sinusitis	NOUN
dti-2103	16	36	(	(	PUNCT
dti-2103	16	37	1	1	NUM
dti-2103	16	38	)	)	PUNCT
dti-2103	16	39	.	.	PUNCT
dti-2103	17	1	pneumococcal	pneumococcal	ADJ
dti-2103	17	2	infections	infection	NOUN
dti-2103	17	3	are	be	AUX
dti-2103	17	4	associated	associate	VERB
dti-2103	17	5	with	with	ADP
dti-2103	17	6	significant	significant	ADJ
dti-2103	17	7	morbidity	morbidity	NOUN
dti-2103	17	8	and	and	CCONJ
dti-2103	17	9	mortality	mortality	NOUN
dti-2103	17	10	globally	globally	ADV
dti-2103	17	11	,	,	PUNCT
dti-2103	17	12	specifically	specifically	ADV
dti-2103	17	13	in	in	ADP
dti-2103	17	14	children	child	NOUN
dti-2103	17	15	younger	young	ADJ
dti-2103	17	16	than	than	ADP
dti-2103	17	17	5	5	NUM
dti-2103	17	18	years	year	NOUN
dti-2103	17	19	,	,	PUNCT
dti-2103	17	20	elderly	elderly	ADJ
dti-2103	17	21	adults	adult	NOUN
dti-2103	17	22	,	,	PUNCT
dti-2103	17	23	and	and	CCONJ
dti-2103	17	24	individuals	individual	NOUN
dti-2103	17	25	with	with	ADP
dti-2103	17	26	immune	immune	ADJ
dti-2103	17	27	deficiencies	deficiency	NOUN
dti-2103	17	28	.	.	PUNCT
dti-2103	18	1	global	global	ADJ
dti-2103	18	2	disease	disease	NOUN
dti-2103	18	3	burden	burden	NOUN
dti-2103	18	4	and	and	CCONJ
dti-2103	18	5	mortality	mortality	NOUN
dti-2103	18	6	estimates	estimate	NOUN
dti-2103	18	7	have	have	AUX
dti-2103	18	8	documented	document	VERB
dti-2103	18	9	341,029	341,029	NUM
dti-2103	18	10	deaths	death	NOUN
dti-2103	18	11	in	in	ADP
dti-2103	18	12	children	child	NOUN
dti-2103	18	13	aged	age	VERB
dti-2103	18	14	below	below	ADP
dti-2103	18	15	5	5	NUM
dti-2103	18	16	years	year	NOUN
dti-2103	18	17	;	;	PUNCT
dti-2103	18	18	494,340	494,340	NUM
dti-2103	18	19	deaths	death	NOUN
dti-2103	18	20	in	in	ADP
dti-2103	18	21	the	the	DET
dti-2103	18	22	elderly	elderly	ADJ
dti-2103	18	23	(	(	PUNCT
dti-2103	18	24	aged	aged	ADJ
dti-2103	18	25	above	above	ADP
dti-2103	18	26	70	70	NUM
dti-2103	18	27	years	year	NOUN
dti-2103	18	28	)	)	PUNCT
dti-2103	18	29	,	,	PUNCT
dti-2103	18	30	and	and	CCONJ
dti-2103	18	31	total	total	VERB
dti-2103	18	32	1,189,937	1,189,937	NUM
dti-2103	18	33	deaths	death	NOUN
dti-2103	18	34	among	among	ADP
dti-2103	18	35	all	all	DET
dti-2103	18	36	ages	age	NOUN
dti-2103	18	37	due	due	ADJ
dti-2103	18	38	to	to	ADP
dti-2103	18	39	pneumococcal	pneumococcal	ADJ
dti-2103	18	40	infections	infection	NOUN
dti-2103	18	41	(	(	PUNCT
dti-2103	18	42	2	2	NUM
dti-2103	18	43	-	-	SYM
dti-2103	18	44	4	4	NUM
dti-2103	18	45	)	)	PUNCT
dti-2103	18	46	.	.	PUNCT
dti-2103	19	1	this	this	DET
dti-2103	19	2	huge	huge	ADJ
dti-2103	19	3	burden	burden	NOUN
dti-2103	19	4	of	of	ADP
dti-2103	19	5	pneumococcal	pneumococcal	ADJ
dti-2103	19	6	diseases	disease	NOUN
dti-2103	19	7	is	be	AUX
dti-2103	19	8	fueled	fuel	VERB
dti-2103	19	9	by	by	ADP
dti-2103	19	10	the	the	DET
dti-2103	19	11	rise	rise	NOUN
dti-2103	19	12	of	of	ADP
dti-2103	19	13	new	new	ADJ
dti-2103	19	14	capsular	capsular	NOUN
dti-2103	19	15	serotypes	serotype	NOUN
dti-2103	19	16	and	and	CCONJ
dti-2103	19	17	spread	spread	VERB
dti-2103	19	18	of	of	ADP
dti-2103	19	19	antimicrobial	antimicrobial	ADJ
dti-2103	19	20	-	-	PUNCT
dti-2103	19	21	resistant	resistant	ADJ
dti-2103	19	22	clones	clone	NOUN
dti-2103	19	23	(	(	PUNCT
dti-2103	19	24	5	5	NUM
dti-2103	19	25	)	)	PUNCT
dti-2103	19	26	.	.	PUNCT
dti-2103	20	1	introduction	introduction	NOUN
dti-2103	20	2	of	of	ADP
dti-2103	20	3	the	the	DET
dti-2103	20	4	capsular	capsular	ADJ
dti-2103	20	5	polysaccharide	polysaccharide	NOUN
dti-2103	20	6	(	(	PUNCT
dti-2103	20	7	cps)based	cps)based	ADJ
dti-2103	20	8	vaccines	vaccine	NOUN
dti-2103	20	9	and	and	CCONJ
dti-2103	20	10	pneumococcal	pneumococcal	ADJ
dti-2103	20	11	conjugate	conjugate	ADJ
dti-2103	20	12	vaccines	vaccine	NOUN
dti-2103	20	13	had	have	AUX
dti-2103	20	14	provided	provide	VERB
dti-2103	20	15	a	a	DET
dti-2103	20	16	little	little	ADJ
dti-2103	20	17	relief	relief	NOUN
dti-2103	20	18	,	,	PUNCT
dti-2103	20	19	but	but	CCONJ
dti-2103	20	20	they	they	PRON
dti-2103	20	21	still	still	ADV
dti-2103	20	22	remain	remain	VERB
dti-2103	20	23	unsatisfactory	unsatisfactory	ADJ
dti-2103	20	24	due	due	ADJ
dti-2103	20	25	to	to	ADP
dti-2103	20	26	limited	limited	ADJ
dti-2103	20	27	serotype	serotype	ADJ
dti-2103	20	28	protection	protection	NOUN
dti-2103	20	29	and	and	CCONJ
dti-2103	20	30	replacement	replacement	NOUN
dti-2103	20	31	,	,	PUNCT
dti-2103	20	32	restricted	restrict	VERB
dti-2103	20	33	efficacy	efficacy	NOUN
dti-2103	20	34	of	of	ADP
dti-2103	20	35	vaccine	vaccine	NOUN
dti-2103	20	36	at	at	ADP
dti-2103	20	37	the	the	DET
dti-2103	20	38	mucosal	mucosal	NOUN
dti-2103	20	39	surface	surface	NOUN
dti-2103	20	40	,	,	PUNCT
dti-2103	20	41	implementation	implementation	NOUN
dti-2103	20	42	issues	issue	NOUN
dti-2103	20	43	,	,	PUNCT
dti-2103	20	44	and	and	CCONJ
dti-2103	20	45	high	high	ADJ
dti-2103	20	46	cost	cost	NOUN
dti-2103	20	47	(	(	PUNCT
dti-2103	20	48	6,7	6,7	NUM
dti-2103	20	49	)	)	PUNCT
dti-2103	20	50	.	.	PUNCT
dti-2103	21	1	hence	hence	ADV
dti-2103	21	2	,	,	PUNCT
dti-2103	21	3	formulation	formulation	NOUN
dti-2103	21	4	of	of	ADP
dti-2103	21	5	alternative	alternative	ADJ
dti-2103	21	6	preventive	preventive	ADJ
dti-2103	21	7	measures	measure	NOUN
dti-2103	21	8	independent	independent	ADJ
dti-2103	21	9	of	of	ADP
dti-2103	21	10	serotypes	serotype	NOUN
dti-2103	21	11	introduction	introduction	NOUN
dti-2103	21	12	streptococcus	streptococcus	VERB
dti-2103	21	13	pneumoniae	pneumoniae	ADJ
dti-2103	21	14	(	(	PUNCT
dti-2103	21	15	pneumococcus	pneumococcus	NOUN
dti-2103	21	16	)	)	PUNCT
dti-2103	21	17	is	be	AUX
dti-2103	21	18	an	an	DET
dti-2103	21	19	important	important	ADJ
dti-2103	21	20	healthcare	healthcare	NOUN
dti-2103	21	21	-	-	PUNCT
dti-2103	21	22	associated	associate	VERB
dti-2103	21	23	pathogen	pathogen	NOUN
dti-2103	21	24	being	be	AUX
dti-2103	21	25	responsible	responsible	ADJ
dti-2103	21	26	for	for	ADP
dti-2103	21	27	various	various	ADJ
dti-2103	21	28	invasive	invasive	ADJ
dti-2103	21	29	pneumococcal	pneumococcal	ADJ
dti-2103	21	30	diseases	disease	NOUN
dti-2103	21	31	(	(	PUNCT
dti-2103	21	32	ipds	ipds	NOUN
dti-2103	21	33	)	)	PUNCT
dti-2103	21	34	,	,	PUNCT
dti-2103	21	35	for	for	ADP
dti-2103	21	36	example	example	NOUN
dti-2103	21	37	,	,	PUNCT
dti-2103	21	38	bacteremia	bacteremia	NOUN
dti-2103	21	39	,	,	PUNCT
dti-2103	21	40	pneumonia	pneumonia	NOUN
dti-2103	21	41	,	,	PUNCT
dti-2103	21	42	septicemia	septicemia	NOUN
dti-2103	21	43	,	,	PUNCT
dti-2103	21	44	and	and	CCONJ
dti-2103	21	45	meningitis	meningitis	PROPN
dti-2103	21	46	,	,	PUNCT
dti-2103	21	47	sharma	sharma	PROPN
dti-2103	21	48	et	et	PROPN
dti-2103	21	49	al	al	PROPN
dti-2103	21	50	27	27	NUM
dti-2103	22	1	©	©	PROPN
dti-2103	22	2	2020	2020	NUM
dti-2103	22	3	the	the	DET
dti-2103	22	4	authors	author	NOUN
dti-2103	22	5	.	.	PUNCT
dti-2103	23	1	published	publish	VERB
dti-2103	23	2	by	by	ADP
dti-2103	23	3	aboutscience	aboutscience	NOUN
dti-2103	23	4	is	be	AUX
dti-2103	23	5	inevitable	inevitable	ADJ
dti-2103	23	6	for	for	ADP
dti-2103	23	7	the	the	DET
dti-2103	23	8	better	well	ADJ
dti-2103	23	9	management	management	NOUN
dti-2103	23	10	of	of	ADP
dti-2103	23	11	pneumococcal	pneumococcal	ADJ
dti-2103	23	12	diseases	disease	NOUN
dti-2103	23	13	.	.	PUNCT
dti-2103	24	1	pneumococcal	pneumococcal	ADJ
dti-2103	24	2	strains	strain	NOUN
dti-2103	24	3	have	have	AUX
dti-2103	24	4	been	be	AUX
dti-2103	24	5	shown	show	VERB
dti-2103	24	6	to	to	PART
dti-2103	24	7	synthesize	synthesize	VERB
dti-2103	24	8	a	a	DET
dti-2103	24	9	distinct	distinct	ADJ
dti-2103	24	10	serotype	serotype	NOUN
dti-2103	24	11	-	-	PUNCT
dti-2103	24	12	specific	specific	ADJ
dti-2103	24	13	polysaccharide	polysaccharide	NOUN
dti-2103	24	14	capsule	capsule	NOUN
dti-2103	24	15	capable	capable	ADJ
dti-2103	24	16	of	of	ADP
dti-2103	24	17	dodging	dodge	VERB
dti-2103	24	18	host	host	NOUN
dti-2103	24	19	immune	immune	ADJ
dti-2103	24	20	components	component	NOUN
dti-2103	24	21	(	(	PUNCT
dti-2103	24	22	8,9	8,9	NUM
dti-2103	24	23	)	)	PUNCT
dti-2103	24	24	.	.	PUNCT
dti-2103	25	1	the	the	DET
dti-2103	25	2	loss	loss	NOUN
dti-2103	25	3	of	of	ADP
dti-2103	25	4	capsule	capsule	NOUN
dti-2103	25	5	has	have	AUX
dti-2103	25	6	been	be	AUX
dti-2103	25	7	associated	associate	VERB
dti-2103	25	8	with	with	ADP
dti-2103	25	9	rapid	rapid	ADJ
dti-2103	25	10	phagocytosis	phagocytosis	NOUN
dti-2103	25	11	(	(	PUNCT
dti-2103	25	12	10,11	10,11	NOUN
dti-2103	25	13	)	)	PUNCT
dti-2103	25	14	.	.	PUNCT
dti-2103	26	1	genetic	genetic	ADJ
dti-2103	26	2	dissection	dissection	NOUN
dti-2103	26	3	of	of	ADP
dti-2103	26	4	the	the	DET
dti-2103	26	5	cps	cps	PROPN
dti-2103	26	6	/	/	SYM
dti-2103	26	7	cap	cap	NOUN
dti-2103	26	8	gene	gene	NOUN
dti-2103	26	9	cluster	cluster	NOUN
dti-2103	26	10	encoding	encoding	NOUN
dti-2103	26	11	for	for	ADP
dti-2103	26	12	cps	cp	NOUN
dti-2103	26	13	had	have	AUX
dti-2103	26	14	strongly	strongly	ADV
dti-2103	26	15	advocated	advocate	VERB
dti-2103	26	16	the	the	DET
dti-2103	26	17	involvement	involvement	NOUN
dti-2103	26	18	of	of	ADP
dti-2103	26	19	other	other	ADJ
dti-2103	26	20	unlinked	unlinked	ADJ
dti-2103	26	21	genes	gene	NOUN
dti-2103	26	22	that	that	PRON
dti-2103	26	23	are	be	AUX
dti-2103	26	24	dispersed	disperse	VERB
dti-2103	26	25	in	in	ADP
dti-2103	26	26	chromosome	chromosome	NOUN
dti-2103	26	27	in	in	ADP
dti-2103	26	28	cps	cps	NOUN
dti-2103	26	29	synthesis	synthesis	NOUN
dti-2103	26	30	(	(	PUNCT
dti-2103	26	31	12,13	12,13	NUM
dti-2103	26	32	)	)	PUNCT
dti-2103	26	33	.	.	PUNCT
dti-2103	27	1	one	one	NUM
dti-2103	27	2	of	of	ADP
dti-2103	27	3	the	the	DET
dti-2103	27	4	genes	gene	NOUN
dti-2103	27	5	,	,	PUNCT
dti-2103	27	6	galu	galu	NOUN
dti-2103	27	7	,	,	PUNCT
dti-2103	27	8	encodes	encode	NOUN
dti-2103	27	9	for	for	ADP
dti-2103	27	10	enzyme	enzyme	NOUN
dti-2103	27	11	uridine	uridine	NOUN
dti-2103	27	12	diphosphate	diphosphate	NOUN
dti-2103	27	13	(	(	PUNCT
dti-2103	27	14	udp)-glucose	udp)-glucose	PROPN
dti-2103	27	15	pyrophosphorylase	pyrophosphorylase	NOUN
dti-2103	27	16	(	(	PUNCT
dti-2103	27	17	ugpase	ugpase	NOUN
dti-2103	27	18	)	)	PUNCT
dti-2103	27	19	,	,	PUNCT
dti-2103	27	20	and	and	CCONJ
dti-2103	27	21	its	its	PRON
dti-2103	27	22	role	role	NOUN
dti-2103	27	23	in	in	ADP
dti-2103	27	24	the	the	DET
dti-2103	27	25	virulence	virulence	NOUN
dti-2103	27	26	of	of	ADP
dti-2103	27	27	various	various	ADJ
dti-2103	27	28	gram	gram	NOUN
dti-2103	27	29	-	-	PUNCT
dti-2103	27	30	negatives	negative	NOUN
dti-2103	27	31	and	and	CCONJ
dti-2103	27	32	gram	gram	NOUN
dti-2103	27	33	-	-	PUNCT
dti-2103	27	34	positives	positive	NOUN
dti-2103	27	35	is	be	AUX
dti-2103	27	36	well	well	ADV
dti-2103	27	37	studied	study	VERB
dti-2103	27	38	(	(	PUNCT
dti-2103	27	39	14	14	NUM
dti-2103	27	40	-	-	SYM
dti-2103	27	41	19	19	NUM
dti-2103	27	42	)	)	PUNCT
dti-2103	27	43	.	.	PUNCT
dti-2103	28	1	ugpase	ugpase	NOUN
dti-2103	28	2	catalyzes	catalyze	VERB
dti-2103	28	3	the	the	DET
dti-2103	28	4	synthesis	synthesis	NOUN
dti-2103	28	5	of	of	ADP
dti-2103	28	6	udpglucose	udpglucose	NOUN
dti-2103	28	7	(	(	PUNCT
dti-2103	28	8	udp	udp	NOUN
dti-2103	28	9	-	-	NOUN
dti-2103	28	10	glc	glc	PROPN
dti-2103	28	11	)	)	PUNCT
dti-2103	28	12	,	,	PUNCT
dti-2103	28	13	which	which	PRON
dti-2103	28	14	is	be	AUX
dti-2103	28	15	an	an	DET
dti-2103	28	16	important	important	ADJ
dti-2103	28	17	glycosyl	glycosyl	NOUN
dti-2103	28	18	donor	donor	NOUN
dti-2103	28	19	for	for	ADP
dti-2103	28	20	the	the	DET
dti-2103	28	21	modification	modification	NOUN
dti-2103	28	22	and	and	CCONJ
dti-2103	28	23	interconversion	interconversion	NOUN
dti-2103	28	24	of	of	ADP
dti-2103	28	25	sugars	sugar	NOUN
dti-2103	28	26	in	in	ADP
dti-2103	28	27	metabolic	metabolic	NOUN
dti-2103	28	28	and	and	CCONJ
dti-2103	28	29	capsular	capsular	VERB
dti-2103	28	30	pathways	pathway	NOUN
dti-2103	28	31	(	(	PUNCT
dti-2103	28	32	17,19,20	17,19,20	NUM
dti-2103	28	33	)	)	PUNCT
dti-2103	28	34	.	.	PUNCT
dti-2103	29	1	the	the	DET
dti-2103	29	2	galu	galu	NOUN
dti-2103	29	3	mutants	mutant	NOUN
dti-2103	29	4	of	of	ADP
dti-2103	29	5	pneumococcus	pneumococcus	NOUN
dti-2103	29	6	have	have	AUX
dti-2103	29	7	been	be	AUX
dti-2103	29	8	shown	show	VERB
dti-2103	29	9	to	to	PART
dti-2103	29	10	be	be	AUX
dti-2103	29	11	acapsular	acapsular	ADJ
dti-2103	29	12	despite	despite	SCONJ
dti-2103	29	13	the	the	DET
dti-2103	29	14	presence	presence	NOUN
dti-2103	29	15	of	of	ADP
dti-2103	29	16	functional	functional	ADJ
dti-2103	29	17	cps	cp	NOUN
dti-2103	29	18	genes	gene	NOUN
dti-2103	29	19	(	(	PUNCT
dti-2103	29	20	14,19	14,19	NUM
dti-2103	29	21	)	)	PUNCT
dti-2103	29	22	.	.	PUNCT
dti-2103	30	1	ugpase	ugpase	NOUN
dti-2103	30	2	has	have	AUX
dti-2103	30	3	been	be	AUX
dti-2103	30	4	considered	consider	VERB
dti-2103	30	5	as	as	ADP
dti-2103	30	6	a	a	DET
dti-2103	30	7	suitable	suitable	ADJ
dti-2103	30	8	target	target	NOUN
dti-2103	30	9	to	to	PART
dti-2103	30	10	control	control	VERB
dti-2103	30	11	the	the	DET
dti-2103	30	12	pneumococcal	pneumococcal	ADJ
dti-2103	30	13	virulence	virulence	NOUN
dti-2103	30	14	(	(	PUNCT
dti-2103	30	15	17,21	17,21	NUM
dti-2103	30	16	)	)	PUNCT
dti-2103	30	17	as	as	SCONJ
dti-2103	30	18	galu	galu	NOUN
dti-2103	30	19	has	have	AUX
dti-2103	30	20	been	be	AUX
dti-2103	30	21	reported	report	VERB
dti-2103	30	22	in	in	ADP
dti-2103	30	23	all	all	DET
dti-2103	30	24	pneumococcal	pneumococcal	ADJ
dti-2103	30	25	strains	strain	NOUN
dti-2103	30	26	regardless	regardless	ADV
dti-2103	30	27	of	of	ADP
dti-2103	30	28	capsular	capsular	ADJ
dti-2103	30	29	types	type	NOUN
dti-2103	30	30	(	(	PUNCT
dti-2103	30	31	14	14	NUM
dti-2103	30	32	)	)	PUNCT
dti-2103	30	33	.	.	PUNCT
dti-2103	31	1	also	also	ADV
dti-2103	31	2	,	,	PUNCT
dti-2103	31	3	mammalian	mammalian	NOUN
dti-2103	31	4	ugpases	ugpase	NOUN
dti-2103	31	5	have	have	AUX
dti-2103	31	6	been	be	AUX
dti-2103	31	7	evolutionarily	evolutionarily	ADV
dti-2103	31	8	unrelated	unrelated	ADJ
dti-2103	31	9	to	to	ADP
dti-2103	31	10	their	their	PRON
dti-2103	31	11	prokaryotic	prokaryotic	ADJ
dti-2103	31	12	counterparts	counterpart	NOUN
dti-2103	31	13	,	,	PUNCT
dti-2103	31	14	suggesting	suggest	VERB
dti-2103	31	15	that	that	SCONJ
dti-2103	31	16	its	its	PRON
dti-2103	31	17	putative	putative	ADJ
dti-2103	31	18	inhibitors	inhibitor	NOUN
dti-2103	31	19	would	would	AUX
dti-2103	31	20	not	not	PART
dti-2103	31	21	be	be	AUX
dti-2103	31	22	inimical	inimical	ADJ
dti-2103	31	23	to	to	ADP
dti-2103	31	24	the	the	DET
dti-2103	31	25	host	host	NOUN
dti-2103	31	26	(	(	PUNCT
dti-2103	31	27	17,21,22	17,21,22	NUM
dti-2103	31	28	)	)	PUNCT
dti-2103	31	29	.	.	PUNCT
dti-2103	32	1	the	the	DET
dti-2103	32	2	effects	effect	NOUN
dti-2103	32	3	of	of	ADP
dti-2103	32	4	ugpase	ugpase	NOUN
dti-2103	32	5	inhibition	inhibition	NOUN
dti-2103	32	6	in	in	ADP
dti-2103	32	7	the	the	DET
dti-2103	32	8	pathogenicity	pathogenicity	NOUN
dti-2103	32	9	of	of	ADP
dti-2103	32	10	pneumococcus	pneumococcus	NOUN
dti-2103	32	11	have	have	AUX
dti-2103	32	12	not	not	PART
dti-2103	32	13	been	be	AUX
dti-2103	32	14	elucidated	elucidate	VERB
dti-2103	32	15	so	so	ADV
dti-2103	32	16	far	far	ADV
dti-2103	32	17	despite	despite	SCONJ
dti-2103	32	18	the	the	DET
dti-2103	32	19	availability	availability	NOUN
dti-2103	32	20	of	of	ADP
dti-2103	32	21	evidence	evidence	NOUN
dti-2103	32	22	of	of	ADP
dti-2103	32	23	gene	gene	NOUN
dti-2103	32	24	mutation	mutation	NOUN
dti-2103	32	25	studies	study	NOUN
dti-2103	32	26	(	(	PUNCT
dti-2103	32	27	19	19	NUM
dti-2103	32	28	)	)	PUNCT
dti-2103	32	29	.	.	PUNCT
dti-2103	33	1	a	a	DET
dti-2103	33	2	study	study	NOUN
dti-2103	33	3	has	have	AUX
dti-2103	33	4	screened	screen	VERB
dti-2103	33	5	few	few	ADJ
dti-2103	33	6	chemical	chemical	ADJ
dti-2103	33	7	inhibitors	inhibitor	NOUN
dti-2103	33	8	for	for	ADP
dti-2103	33	9	the	the	DET
dti-2103	33	10	inhibition	inhibition	NOUN
dti-2103	33	11	of	of	ADP
dti-2103	33	12	ugpase	ugpase	NOUN
dti-2103	33	13	activity	activity	NOUN
dti-2103	33	14	in	in	ADP
dti-2103	33	15	a	a	DET
dti-2103	33	16	calorimetric	calorimetric	ADJ
dti-2103	33	17	assay	assay	NOUN
dti-2103	33	18	from	from	ADP
dti-2103	33	19	purified	purified	ADJ
dti-2103	33	20	extracts	extract	NOUN
dti-2103	33	21	(	(	PUNCT
dti-2103	33	22	23	23	NUM
dti-2103	33	23	)	)	PUNCT
dti-2103	33	24	,	,	PUNCT
dti-2103	33	25	but	but	CCONJ
dti-2103	33	26	no	no	DET
dti-2103	33	27	study	study	NOUN
dti-2103	33	28	is	be	AUX
dti-2103	33	29	available	available	ADJ
dti-2103	33	30	on	on	ADP
dti-2103	33	31	inhibitormediated	inhibitormediate	VERB
dti-2103	33	32	host	host	NOUN
dti-2103	33	33	-	-	PUNCT
dti-2103	33	34	pathogen	pathogen	NOUN
dti-2103	33	35	interaction	interaction	NOUN
dti-2103	33	36	.	.	PUNCT
dti-2103	34	1	therefore	therefore	ADV
dti-2103	34	2	,	,	PUNCT
dti-2103	34	3	for	for	ADP
dti-2103	34	4	the	the	DET
dti-2103	34	5	selection	selection	NOUN
dti-2103	34	6	of	of	ADP
dti-2103	34	7	ugpase	ugpase	NOUN
dti-2103	34	8	inhibitor	inhibitor	NOUN
dti-2103	34	9	,	,	PUNCT
dti-2103	34	10	we	we	PRON
dti-2103	34	11	modeled	model	VERB
dti-2103	34	12	and	and	CCONJ
dti-2103	34	13	analyzed	analyze	VERB
dti-2103	34	14	the	the	DET
dti-2103	34	15	structure	structure	NOUN
dti-2103	34	16	of	of	ADP
dti-2103	34	17	s.	s.	PROPN
dti-2103	34	18	pneumoniae	pneumoniae	ADJ
dti-2103	34	19	ugpase	ugpase	NOUN
dti-2103	34	20	using	use	VERB
dti-2103	34	21	i	i	NOUN
dti-2103	34	22	-	-	PUNCT
dti-2103	34	23	tasser	tasser	NOUN
dti-2103	34	24	(	(	PUNCT
dti-2103	34	25	iterativethreading	iterativethreade	VERB
dti-2103	34	26	assembly	assembly	NOUN
dti-2103	34	27	refinement	refinement	NOUN
dti-2103	34	28	)	)	PUNCT
dti-2103	34	29	server	server	NOUN
dti-2103	34	30	(	(	PUNCT
dti-2103	34	31	http://zhang.bioinformatics.ku.edu/i-tasser	http://zhang.bioinformatics.ku.edu/i-tasser	NOUN
dti-2103	34	32	)	)	PUNCT
dti-2103	34	33	to	to	PART
dti-2103	34	34	delineate	delineate	VERB
dti-2103	34	35	its	its	PRON
dti-2103	34	36	tertiary	tertiary	ADJ
dti-2103	34	37	structure	structure	NOUN
dti-2103	34	38	,	,	PUNCT
dti-2103	34	39	active	active	ADJ
dti-2103	34	40	site	site	NOUN
dti-2103	34	41	residues	residue	NOUN
dti-2103	34	42	,	,	PUNCT
dti-2103	34	43	and	and	CCONJ
dti-2103	34	44	properties	property	NOUN
dti-2103	34	45	.	.	PUNCT
dti-2103	35	1	in	in	ADP
dti-2103	35	2	this	this	DET
dti-2103	35	3	study	study	NOUN
dti-2103	35	4	,	,	PUNCT
dti-2103	35	5	we	we	PRON
dti-2103	35	6	have	have	AUX
dti-2103	35	7	studied	study	VERB
dti-2103	35	8	the	the	DET
dti-2103	35	9	effect	effect	NOUN
dti-2103	35	10	of	of	ADP
dti-2103	35	11	ugpase	ugpase	NOUN
dti-2103	35	12	inhibition	inhibition	NOUN
dti-2103	35	13	on	on	ADP
dti-2103	35	14	the	the	DET
dti-2103	35	15	virulence	virulence	NOUN
dti-2103	35	16	of	of	ADP
dti-2103	35	17	s.	s.	PROPN
dti-2103	35	18	pneumoniae	pneumoniae	ADJ
dti-2103	35	19	during	during	ADP
dti-2103	35	20	host	host	NOUN
dti-2103	35	21	-	-	PUNCT
dti-2103	35	22	pathogen	pathogen	NOUN
dti-2103	35	23	interactions	interaction	NOUN
dti-2103	35	24	and	and	CCONJ
dti-2103	35	25	validated	validate	VERB
dti-2103	35	26	a	a	DET
dti-2103	35	27	putative	putative	ADJ
dti-2103	35	28	inhibitor	inhibitor	NOUN
dti-2103	35	29	of	of	ADP
dti-2103	35	30	pneumococcal	pneumococcal	ADJ
dti-2103	35	31	ugpase	ugpase	NOUN
dti-2103	35	32	for	for	ADP
dti-2103	35	33	its	its	PRON
dti-2103	35	34	inhibition	inhibition	NOUN
dti-2103	35	35	potentials	potential	NOUN
dti-2103	35	36	and	and	CCONJ
dti-2103	35	37	efficacy	efficacy	NOUN
dti-2103	35	38	in	in	ADP
dti-2103	35	39	vitro	vitro	X
dti-2103	35	40	.	.	PUNCT
dti-2103	36	1	materials	material	NOUN
dti-2103	36	2	and	and	CCONJ
dti-2103	36	3	methods	method	NOUN
dti-2103	36	4	this	this	DET
dti-2103	36	5	study	study	NOUN
dti-2103	36	6	was	be	AUX
dti-2103	36	7	approved	approve	VERB
dti-2103	36	8	by	by	ADP
dti-2103	36	9	the	the	DET
dti-2103	36	10	institute	institute	PROPN
dti-2103	36	11	ethics	ethics	PROPN
dti-2103	36	12	committee	committee	PROPN
dti-2103	36	13	(	(	PUNCT
dti-2103	36	14	iec	iec	PROPN
dti-2103	36	15	memo	memo	NOUN
dti-2103	36	16	no	no	NOUN
dti-2103	36	17	.	.	NOUN
dti-2103	36	18	87770	87770	NUM
dti-2103	36	19	-	-	PUNCT
dti-2103	36	20	pg11	pg11	PROPN
dti-2103	36	21	-	-	PUNCT
dti-2103	36	22	itrg/11384	itrg/11384	NOUN
dti-2103	36	23	)	)	PUNCT
dti-2103	36	24	.	.	PUNCT
dti-2103	37	1	respiratory	respiratory	ADJ
dti-2103	37	2	epithelial	epithelial	NOUN
dti-2103	37	3	(	(	PUNCT
dti-2103	37	4	a549	a549	PROPN
dti-2103	37	5	and	and	CCONJ
dti-2103	37	6	hep-2	hep-2	PUNCT
dti-2103	37	7	)	)	PUNCT
dti-2103	37	8	and	and	CCONJ
dti-2103	37	9	macrophage	macrophage	ADJ
dti-2103	37	10	(	(	PUNCT
dti-2103	37	11	j774.a.1	j774.a.1	PROPN
dti-2103	37	12	and	and	CCONJ
dti-2103	37	13	thp1	thp1	PROPN
dti-2103	37	14	)	)	PUNCT
dti-2103	37	15	cell	cell	NOUN
dti-2103	37	16	lines	line	NOUN
dti-2103	37	17	were	be	AUX
dti-2103	37	18	procured	procure	VERB
dti-2103	37	19	from	from	ADP
dti-2103	37	20	the	the	DET
dti-2103	37	21	cell	cell	NOUN
dti-2103	37	22	repository	repository	NOUN
dti-2103	37	23	of	of	ADP
dti-2103	37	24	national	national	ADJ
dti-2103	37	25	centre	centre	NOUN
dti-2103	37	26	for	for	ADP
dti-2103	37	27	cell	cell	NOUN
dti-2103	37	28	sciences	science	NOUN
dti-2103	37	29	(	(	PUNCT
dti-2103	37	30	nccs	nccs	PROPN
dti-2103	37	31	)	)	PUNCT
dti-2103	37	32	,	,	PUNCT
dti-2103	37	33	pune	pune	NOUN
dti-2103	37	34	,	,	PUNCT
dti-2103	37	35	india	india	PROPN
dti-2103	37	36	.	.	PUNCT
dti-2103	38	1	s.	s.	PROPN
dti-2103	38	2	pneumoniae	pneumoniae	ADJ
dti-2103	38	3	reference	reference	NOUN
dti-2103	38	4	strains	strain	VERB
dti-2103	38	5	d39	d39	NOUN
dti-2103	38	6	(	(	PUNCT
dti-2103	38	7	nctc	nctc	NOUN
dti-2103	38	8	7466	7466	NUM
dti-2103	38	9	)	)	PUNCT
dti-2103	38	10	and	and	CCONJ
dti-2103	38	11	mtcc	mtcc	NOUN
dti-2103	38	12	655	655	NUM
dti-2103	38	13	(	(	PUNCT
dti-2103	38	14	nctc	nctc	NOUN
dti-2103	38	15	7465	7465	NUM
dti-2103	38	16	)	)	PUNCT
dti-2103	38	17	were	be	AUX
dti-2103	38	18	procured	procure	VERB
dti-2103	38	19	from	from	ADP
dti-2103	38	20	microbial	microbial	ADJ
dti-2103	38	21	type	type	NOUN
dti-2103	38	22	culture	culture	NOUN
dti-2103	38	23	collection	collection	NOUN
dti-2103	38	24	(	(	PUNCT
dti-2103	38	25	mtcc	mtcc	ADJ
dti-2103	38	26	)	)	PUNCT
dti-2103	38	27	,	,	PUNCT
dti-2103	38	28	imtech	imtech	ADJ
dti-2103	38	29	,	,	PUNCT
dti-2103	38	30	chandigarh	chandigarh	PROPN
dti-2103	38	31	,	,	PUNCT
dti-2103	38	32	india	india	PROPN
dti-2103	38	33	.	.	PUNCT
dti-2103	39	1	a	a	DET
dti-2103	39	2	clinical	clinical	ADJ
dti-2103	39	3	blood	blood	NOUN
dti-2103	39	4	isolate	isolate	NOUN
dti-2103	39	5	of	of	ADP
dti-2103	39	6	serotype	serotype	PROPN
dti-2103	39	7	19f	19f	PROPN
dti-2103	39	8	was	be	AUX
dti-2103	39	9	also	also	ADV
dti-2103	39	10	used	use	VERB
dti-2103	39	11	in	in	ADP
dti-2103	39	12	the	the	DET
dti-2103	39	13	study	study	NOUN
dti-2103	39	14	as	as	SCONJ
dti-2103	39	15	its	its	PRON
dti-2103	39	16	occurrence	occurrence	NOUN
dti-2103	39	17	has	have	AUX
dti-2103	39	18	been	be	AUX
dti-2103	39	19	reported	report	VERB
dti-2103	39	20	frequently	frequently	ADV
dti-2103	39	21	in	in	ADP
dti-2103	39	22	ipds	ipds	PROPN
dti-2103	39	23	.	.	PUNCT
dti-2103	40	1	clinical	clinical	ADJ
dti-2103	40	2	strain	strain	NOUN
dti-2103	40	3	was	be	AUX
dti-2103	40	4	isolated	isolate	VERB
dti-2103	40	5	from	from	ADP
dti-2103	40	6	the	the	DET
dti-2103	40	7	blood	blood	NOUN
dti-2103	40	8	sample	sample	NOUN
dti-2103	40	9	of	of	ADP
dti-2103	40	10	a	a	DET
dti-2103	40	11	patient	patient	NOUN
dti-2103	40	12	suffering	suffering	NOUN
dti-2103	40	13	from	from	ADP
dti-2103	40	14	lower	low	ADJ
dti-2103	40	15	respiratory	respiratory	ADJ
dti-2103	40	16	tract	tract	NOUN
dti-2103	40	17	infection	infection	NOUN
dti-2103	40	18	of	of	ADP
dti-2103	40	19	s.	s.	PROPN
dti-2103	40	20	pneumoniae	pneumoniae	ADJ
dti-2103	40	21	only	only	ADV
dti-2103	40	22	.	.	PUNCT
dti-2103	41	1	cell	cell	NOUN
dti-2103	41	2	culture	culture	NOUN
dti-2103	41	3	a549	a549	PROPN
dti-2103	41	4	and	and	CCONJ
dti-2103	41	5	thp1	thp1	NOUN
dti-2103	41	6	cell	cell	NOUN
dti-2103	41	7	lines	line	NOUN
dti-2103	41	8	were	be	AUX
dti-2103	41	9	cultured	cultured	ADJ
dti-2103	41	10	and	and	CCONJ
dti-2103	41	11	maintained	maintain	VERB
dti-2103	41	12	in	in	ADP
dti-2103	41	13	rpmi	rpmi	NOUN
dti-2103	41	14	1640	1640	NUM
dti-2103	41	15	,	,	PUNCT
dti-2103	41	16	while	while	SCONJ
dti-2103	41	17	hep-2	hep-2	ADJ
dti-2103	41	18	and	and	CCONJ
dti-2103	41	19	j774.a.1	j774.a.1	PROPN
dti-2103	41	20	cell	cell	NOUN
dti-2103	41	21	lines	line	NOUN
dti-2103	41	22	were	be	AUX
dti-2103	41	23	cultured	cultured	ADJ
dti-2103	41	24	in	in	ADP
dti-2103	41	25	minimal	minimal	ADJ
dti-2103	41	26	essential	essential	ADJ
dti-2103	41	27	medium	medium	ADJ
dti-2103	41	28	(	(	PUNCT
dti-2103	41	29	mem	mem	ADJ
dti-2103	41	30	)	)	PUNCT
dti-2103	41	31	and	and	CCONJ
dti-2103	41	32	dulbecco	dulbecco	NOUN
dti-2103	41	33	’s	’s	PART
dti-2103	41	34	modified	modified	PROPN
dti-2103	41	35	eagle	eagle	PROPN
dti-2103	41	36	’s	’s	PART
dti-2103	41	37	medium	medium	ADJ
dti-2103	41	38	(	(	PUNCT
dti-2103	41	39	dmem	dmem	ADJ
dti-2103	41	40	)	)	PUNCT
dti-2103	41	41	,	,	PUNCT
dti-2103	41	42	respectively	respectively	ADV
dti-2103	41	43	,	,	PUNCT
dti-2103	41	44	at	at	ADP
dti-2103	41	45	37	37	NUM
dti-2103	41	46	°	°	ADP
dti-2103	41	47	c	c	NOUN
dti-2103	41	48	with	with	ADP
dti-2103	41	49	5	5	NUM
dti-2103	41	50	%	%	NOUN
dti-2103	41	51	co2	co2	NOUN
dti-2103	41	52	.	.	PUNCT
dti-2103	42	1	all	all	DET
dti-2103	42	2	the	the	DET
dti-2103	42	3	media	medium	NOUN
dti-2103	42	4	were	be	AUX
dti-2103	42	5	supplemented	supplement	VERB
dti-2103	42	6	with	with	ADP
dti-2103	42	7	10	10	NUM
dti-2103	42	8	%	%	NOUN
dti-2103	42	9	(	(	PUNCT
dti-2103	42	10	v	v	NOUN
dti-2103	42	11	/	/	SYM
dti-2103	42	12	v	v	NOUN
dti-2103	42	13	)	)	PUNCT
dti-2103	42	14	heatinactivated	heatinactivate	VERB
dti-2103	42	15	fetal	fetal	ADJ
dti-2103	42	16	bovine	bovine	NOUN
dti-2103	42	17	serum	serum	NOUN
dti-2103	42	18	(	(	PUNCT
dti-2103	42	19	fbs	fbs	PROPN
dti-2103	42	20	)	)	PUNCT
dti-2103	42	21	,	,	PUNCT
dti-2103	42	22	0.15	0.15	NUM
dti-2103	42	23	%	%	NOUN
dti-2103	42	24	(	(	PUNCT
dti-2103	42	25	v	v	NOUN
dti-2103	42	26	/	/	SYM
dti-2103	42	27	v	v	NOUN
dti-2103	42	28	)	)	PUNCT
dti-2103	42	29	sodium	sodium	NOUN
dti-2103	42	30	bicarbonate	bicarbonate	NOUN
dti-2103	42	31	,	,	PUNCT
dti-2103	42	32	streptomycin	streptomycin	PROPN
dti-2103	42	33	(	(	PUNCT
dti-2103	42	34	100	100	NUM
dti-2103	42	35	µg	µg	NOUN
dti-2103	42	36	/	/	SYM
dti-2103	42	37	ml	ml	NOUN
dti-2103	42	38	)	)	PUNCT
dti-2103	42	39	,	,	PUNCT
dti-2103	42	40	and	and	CCONJ
dti-2103	42	41	penicillin	penicillin	NOUN
dti-2103	42	42	(	(	PUNCT
dti-2103	42	43	100	100	NUM
dti-2103	42	44	u	u	NOUN
dti-2103	42	45	/	/	SYM
dti-2103	42	46	ml	ml	VERB
dti-2103	42	47	)	)	PUNCT
dti-2103	42	48	.	.	PUNCT
dti-2103	43	1	antibiotic	antibiotic	ADJ
dti-2103	43	2	-	-	PUNCT
dti-2103	43	3	free	free	ADJ
dti-2103	43	4	media	medium	NOUN
dti-2103	43	5	were	be	AUX
dti-2103	43	6	prepared	prepare	VERB
dti-2103	43	7	for	for	ADP
dti-2103	43	8	experiments	experiment	NOUN
dti-2103	43	9	involving	involve	VERB
dti-2103	43	10	bacterial	bacterial	ADJ
dti-2103	43	11	infection	infection	NOUN
dti-2103	43	12	.	.	PUNCT
dti-2103	44	1	udp	udp	NOUN
dti-2103	44	2	as	as	SCONJ
dti-2103	44	3	ugpase	ugpase	VERB
dti-2103	44	4	inhibitor	inhibitor	NOUN
dti-2103	44	5	effective	effective	ADJ
dti-2103	44	6	concentration	concentration	NOUN
dti-2103	44	7	of	of	ADP
dti-2103	44	8	udp	udp	NOUN
dti-2103	44	9	as	as	SCONJ
dti-2103	44	10	inhibitor	inhibitor	NOUN
dti-2103	44	11	of	of	ADP
dti-2103	44	12	ugpase	ugpase	NOUN
dti-2103	44	13	was	be	AUX
dti-2103	44	14	evaluated	evaluate	VERB
dti-2103	44	15	by	by	ADP
dti-2103	44	16	ugpase	ugpase	NOUN
dti-2103	44	17	assay	assay	PROPN
dti-2103	44	18	(	(	PUNCT
dti-2103	44	19	17	17	NUM
dti-2103	44	20	)	)	PUNCT
dti-2103	44	21	in	in	ADP
dti-2103	44	22	both	both	PRON
dti-2103	44	23	s.	s.	PROPN
dti-2103	44	24	pneumoniae	pneumoniae	NOUN
dti-2103	44	25	and	and	CCONJ
dti-2103	44	26	a549	a549	PROPN
dti-2103	44	27	cells	cell	NOUN
dti-2103	44	28	.	.	PUNCT
dti-2103	45	1	log	log	NOUN
dti-2103	45	2	phase	phase	NOUN
dti-2103	45	3	culture	culture	NOUN
dti-2103	45	4	of	of	ADP
dti-2103	45	5	s.	s.	PROPN
dti-2103	45	6	pneumoniae	pneumoniae	PROPN
dti-2103	45	7	and	and	CCONJ
dti-2103	45	8	confluent	confluent	ADJ
dti-2103	45	9	cell	cell	NOUN
dti-2103	45	10	monolayers	monolayer	NOUN
dti-2103	45	11	were	be	AUX
dti-2103	45	12	treated	treat	VERB
dti-2103	45	13	with	with	ADP
dti-2103	45	14	udp	udp	NOUN
dti-2103	45	15	at	at	ADP
dti-2103	45	16	different	different	ADJ
dti-2103	45	17	concentrations	concentration	NOUN
dti-2103	45	18	for	for	ADP
dti-2103	45	19	1	1	NUM
dti-2103	45	20	hour	hour	NOUN
dti-2103	45	21	at	at	ADP
dti-2103	45	22	37	37	NUM
dti-2103	45	23	°	°	NOUN
dti-2103	45	24	c	c	NOUN
dti-2103	45	25	and	and	CCONJ
dti-2103	45	26	5	5	NUM
dti-2103	45	27	%	%	NOUN
dti-2103	45	28	co2	co2	NOUN
dti-2103	45	29	.	.	PUNCT
dti-2103	46	1	a549	a549	PROPN
dti-2103	46	2	cells	cell	NOUN
dti-2103	46	3	in	in	ADP
dti-2103	46	4	phosphate	phosphate	NOUN
dti-2103	46	5	-	-	PUNCT
dti-2103	46	6	buffered	buffer	VERB
dti-2103	46	7	saline	saline	NOUN
dti-2103	46	8	(	(	PUNCT
dti-2103	46	9	pbs	pbs	PROPN
dti-2103	46	10	)	)	PUNCT
dti-2103	46	11	were	be	AUX
dti-2103	46	12	lysed	lyse	VERB
dti-2103	46	13	with	with	ADP
dti-2103	46	14	three	three	NUM
dti-2103	46	15	cycles	cycle	NOUN
dti-2103	46	16	of	of	ADP
dti-2103	46	17	temperature	temperature	NOUN
dti-2103	46	18	-	-	PUNCT
dti-2103	46	19	shock	shock	NOUN
dti-2103	46	20	(	(	PUNCT
dti-2103	46	21	5	5	NUM
dti-2103	46	22	minutes	minute	NOUN
dti-2103	46	23	each	each	PRON
dti-2103	46	24	)	)	PUNCT
dti-2103	46	25	.	.	PUNCT
dti-2103	47	1	bacterial	bacterial	ADJ
dti-2103	47	2	pellets	pellet	NOUN
dti-2103	47	3	were	be	AUX
dti-2103	47	4	sonicated	sonicate	VERB
dti-2103	47	5	(	(	PUNCT
dti-2103	47	6	3	3	NUM
dti-2103	47	7	cycles	cycle	NOUN
dti-2103	47	8	;	;	PUNCT
dti-2103	47	9	pulse	pulse	NOUN
dti-2103	47	10	10	10	NUM
dti-2103	47	11	seconds	second	NOUN
dti-2103	47	12	on	on	ADP
dti-2103	47	13	,	,	PUNCT
dti-2103	47	14	30	30	NUM
dti-2103	47	15	seconds	second	NOUN
dti-2103	47	16	off	off	ADV
dti-2103	47	17	)	)	PUNCT
dti-2103	47	18	in	in	ADP
dti-2103	47	19	ice	ice	NOUN
dti-2103	47	20	bath	bath	NOUN
dti-2103	47	21	.	.	PUNCT
dti-2103	48	1	ugpase	ugpase	NOUN
dti-2103	48	2	activity	activity	NOUN
dti-2103	48	3	was	be	AUX
dti-2103	48	4	assessed	assess	VERB
dti-2103	48	5	in	in	ADP
dti-2103	48	6	total	total	ADJ
dti-2103	48	7	1	1	NUM
dti-2103	48	8	ml	ml	NOUN
dti-2103	48	9	reaction	reaction	NOUN
dti-2103	48	10	mixture	mixture	NOUN
dti-2103	48	11	with	with	ADP
dti-2103	48	12	freshly	freshly	ADV
dti-2103	48	13	prepared	prepare	VERB
dti-2103	48	14	extracts	extract	NOUN
dti-2103	48	15	(	(	PUNCT
dti-2103	48	16	100	100	NUM
dti-2103	48	17	μl	μl	PRON
dti-2103	48	18	)	)	PUNCT
dti-2103	48	19	at	at	ADP
dti-2103	48	20	25	25	NUM
dti-2103	48	21	°	°	NOUN
dti-2103	48	22	c	c	NOUN
dti-2103	48	23	.	.	PUNCT
dti-2103	49	1	reaction	reaction	NOUN
dti-2103	49	2	mixture	mixture	NOUN
dti-2103	49	3	constituted	constitute	VERB
dti-2103	49	4	50	50	NUM
dti-2103	49	5	mm	mm	NUM
dti-2103	49	6	tris	tris	PROPN
dti-2103	49	7	-	-	PUNCT
dti-2103	49	8	hcl	hcl	NOUN
dti-2103	49	9	buffer	buffer	NOUN
dti-2103	49	10	(	(	PUNCT
dti-2103	49	11	ph	ph	NOUN
dti-2103	49	12	7.5	7.5	NUM
dti-2103	49	13	)	)	PUNCT
dti-2103	49	14	,	,	PUNCT
dti-2103	49	15	16	16	NUM
dti-2103	49	16	mm	mm	NOUN
dti-2103	49	17	mgcl2	mgcl2	PROPN
dti-2103	49	18	,	,	PUNCT
dti-2103	49	19	0.6	0.6	NUM
dti-2103	49	20	mm	mm	NOUN
dti-2103	49	21	β	β	NOUN
dti-2103	49	22	-	-	NOUN
dti-2103	49	23	nicotinamide	nicotinamide	NOUN
dti-2103	49	24	adenine	adenine	ADJ
dti-2103	49	25	dinucleotide	dinucleotide	NOUN
dti-2103	49	26	phosphate	phosphate	NOUN
dti-2103	49	27	(	(	PUNCT
dti-2103	49	28	nadp	nadp	PROPN
dti-2103	49	29	)	)	PUNCT
dti-2103	49	30	,	,	PUNCT
dti-2103	49	31	0.6	0.6	NUM
dti-2103	49	32	mm	mm	PROPN
dti-2103	49	33	udp	udp	NOUN
dti-2103	49	34	-	-	NOUN
dti-2103	49	35	glucose	glucose	NOUN
dti-2103	49	36	,	,	PUNCT
dti-2103	49	37	udp	udp	NOUN
dti-2103	49	38	-	-	NOUN
dti-2103	49	39	glucose	glucose	NOUN
dti-2103	49	40	dehydrogenase	dehydrogenase	NOUN
dti-2103	49	41	(	(	PUNCT
dti-2103	49	42	0.7	0.7	NUM
dti-2103	49	43	u	u	NOUN
dti-2103	49	44	)	)	PUNCT
dti-2103	49	45	,	,	PUNCT
dti-2103	49	46	and	and	CCONJ
dti-2103	49	47	phosphoglucomutase	phosphoglucomutase	NOUN
dti-2103	49	48	(	(	PUNCT
dti-2103	49	49	0.07	0.07	NUM
dti-2103	49	50	u	u	NOUN
dti-2103	49	51	)	)	PUNCT
dti-2103	49	52	.	.	PUNCT
dti-2103	50	1	reaction	reaction	NOUN
dti-2103	50	2	was	be	AUX
dti-2103	50	3	initiated	initiate	VERB
dti-2103	50	4	with	with	ADP
dti-2103	50	5	the	the	DET
dti-2103	50	6	addition	addition	NOUN
dti-2103	50	7	of	of	ADP
dti-2103	50	8	sodium	sodium	NOUN
dti-2103	50	9	pyrophosphate	pyrophosphate	NOUN
dti-2103	50	10	(	(	PUNCT
dti-2103	50	11	1.7	1.7	NUM
dti-2103	50	12	mm	mm	NOUN
dti-2103	50	13	)	)	PUNCT
dti-2103	50	14	and	and	CCONJ
dti-2103	50	15	nadph	nadph	ADJ
dti-2103	50	16	formation	formation	NOUN
dti-2103	50	17	was	be	AUX
dti-2103	50	18	determined	determine	VERB
dti-2103	50	19	by	by	ADP
dti-2103	50	20	measuring	measure	VERB
dti-2103	50	21	the	the	DET
dti-2103	50	22	increase	increase	NOUN
dti-2103	50	23	in	in	ADP
dti-2103	50	24	absorbance	absorbance	NOUN
dti-2103	50	25	at	at	ADP
dti-2103	50	26	340	340	NUM
dti-2103	50	27	nm	nm	NOUN
dti-2103	50	28	.	.	PUNCT
dti-2103	51	1	blank	blank	PROPN
dti-2103	51	2	consisted	consist	VERB
dti-2103	51	3	of	of	ADP
dti-2103	51	4	reaction	reaction	NOUN
dti-2103	51	5	mixture	mixture	NOUN
dti-2103	51	6	without	without	ADP
dti-2103	51	7	cell	cell	NOUN
dti-2103	51	8	or	or	CCONJ
dti-2103	51	9	bacterial	bacterial	ADJ
dti-2103	51	10	extract	extract	NOUN
dti-2103	51	11	.	.	PUNCT
dti-2103	52	1	inhibitor	inhibitor	NOUN
dti-2103	52	2	toxicity	toxicity	NOUN
dti-2103	52	3	to	to	ADP
dti-2103	52	4	host	host	NOUN
dti-2103	52	5	cells	cell	NOUN
dti-2103	52	6	a549	a549	PART
dti-2103	52	7	cell	cell	NOUN
dti-2103	52	8	monolayers	monolayer	NOUN
dti-2103	52	9	were	be	AUX
dti-2103	52	10	treated	treat	VERB
dti-2103	52	11	with	with	ADP
dti-2103	52	12	different	different	ADJ
dti-2103	52	13	concentrations	concentration	NOUN
dti-2103	52	14	of	of	ADP
dti-2103	52	15	udp	udp	NOUN
dti-2103	52	16	for	for	ADP
dti-2103	52	17	1	1	NUM
dti-2103	52	18	hour	hour	NOUN
dti-2103	52	19	at	at	ADP
dti-2103	52	20	37	37	NUM
dti-2103	52	21	°	°	NOUN
dti-2103	52	22	c	c	NOUN
dti-2103	52	23	and	and	CCONJ
dti-2103	52	24	untreated	untreated	ADJ
dti-2103	52	25	cells	cell	NOUN
dti-2103	52	26	were	be	AUX
dti-2103	52	27	taken	take	VERB
dti-2103	52	28	as	as	ADP
dti-2103	52	29	reference	reference	NOUN
dti-2103	52	30	.	.	PUNCT
dti-2103	53	1	the	the	DET
dti-2103	53	2	effect	effect	NOUN
dti-2103	53	3	of	of	ADP
dti-2103	53	4	udp	udp	NOUN
dti-2103	53	5	on	on	ADP
dti-2103	53	6	viability	viability	NOUN
dti-2103	53	7	of	of	ADP
dti-2103	53	8	cells	cell	NOUN
dti-2103	53	9	was	be	AUX
dti-2103	53	10	evaluated	evaluate	VERB
dti-2103	53	11	using	use	VERB
dti-2103	53	12	mtt	mtt	NOUN
dti-2103	53	13	assay	assay	NOUN
dti-2103	53	14	(	(	PUNCT
dti-2103	53	15	24	24	NUM
dti-2103	53	16	)	)	PUNCT
dti-2103	53	17	.	.	PUNCT
dti-2103	54	1	briefly	briefly	NOUN
dti-2103	54	2	,	,	PUNCT
dti-2103	54	3	mtt	mtt	NOUN
dti-2103	54	4	solution	solution	NOUN
dti-2103	54	5	(	(	PUNCT
dti-2103	54	6	2.5	2.5	NUM
dti-2103	54	7	mg	mg	NOUN
dti-2103	54	8	/	/	SYM
dti-2103	54	9	ml	ml	PROPN
dti-2103	54	10	;	;	PUNCT
dti-2103	54	11	sigma	sigma	PROPN
dti-2103	54	12	)	)	PUNCT
dti-2103	54	13	was	be	AUX
dti-2103	54	14	added	add	VERB
dti-2103	54	15	to	to	ADP
dti-2103	54	16	monolayers	monolayer	NOUN
dti-2103	54	17	and	and	CCONJ
dti-2103	54	18	incubated	incubate	VERB
dti-2103	54	19	for	for	ADP
dti-2103	54	20	4	4	NUM
dti-2103	54	21	hours	hour	NOUN
dti-2103	54	22	.	.	PUNCT
dti-2103	55	1	media	medium	NOUN
dti-2103	55	2	containing	contain	VERB
dti-2103	55	3	mtt	mtt	NOUN
dti-2103	55	4	was	be	AUX
dti-2103	55	5	discarded	discard	VERB
dti-2103	55	6	and	and	CCONJ
dti-2103	55	7	dimethyl	dimethyl	NOUN
dti-2103	55	8	sulfoxide	sulfoxide	NOUN
dti-2103	55	9	(	(	PUNCT
dti-2103	55	10	dmso	dmso	NOUN
dti-2103	55	11	,	,	PUNCT
dti-2103	55	12	200	200	NUM
dti-2103	55	13	µl	µl	NOUN
dti-2103	55	14	)	)	PUNCT
dti-2103	55	15	was	be	AUX
dti-2103	55	16	added	add	VERB
dti-2103	55	17	.	.	PUNCT
dti-2103	56	1	absorbance	absorbance	NOUN
dti-2103	56	2	was	be	AUX
dti-2103	56	3	recorded	record	VERB
dti-2103	56	4	at	at	ADP
dti-2103	56	5	590	590	NUM
dti-2103	56	6	nm	nm	NOUN
dti-2103	56	7	in	in	ADP
dti-2103	56	8	microplate	microplate	PROPN
dti-2103	56	9	reader	reader	PROPN
dti-2103	56	10	(	(	PUNCT
dti-2103	56	11	bio	bio	NOUN
dti-2103	56	12	-	-	NOUN
dti-2103	56	13	rad	rad	PROPN
dti-2103	56	14	680	680	NUM
dti-2103	56	15	)	)	PUNCT
dti-2103	56	16	.	.	PUNCT
dti-2103	57	1	expression	expression	NOUN
dti-2103	57	2	of	of	ADP
dti-2103	57	3	ugpase	ugpase	NOUN
dti-2103	57	4	in	in	ADP
dti-2103	57	5	host	host	NOUN
dti-2103	57	6	cells	cell	NOUN
dti-2103	57	7	a549	a549	PROPN
dti-2103	57	8	and	and	CCONJ
dti-2103	57	9	hep-2	hep-2	PUNCT
dti-2103	57	10	monolayers	monolayer	NOUN
dti-2103	57	11	were	be	AUX
dti-2103	57	12	treated	treat	VERB
dti-2103	57	13	with	with	ADP
dti-2103	57	14	udp	udp	NOUN
dti-2103	57	15	at	at	ADP
dti-2103	57	16	effective	effective	ADJ
dti-2103	57	17	inhibiting	inhibit	VERB
dti-2103	57	18	dose	dose	NOUN
dti-2103	57	19	for	for	ADP
dti-2103	57	20	1	1	NUM
dti-2103	57	21	hour	hour	NOUN
dti-2103	57	22	at	at	ADP
dti-2103	57	23	37	37	NUM
dti-2103	57	24	°	°	NOUN
dti-2103	57	25	c	c	NOUN
dti-2103	57	26	,	,	PUNCT
dti-2103	57	27	5	5	NUM
dti-2103	57	28	%	%	NOUN
dti-2103	57	29	co2	co2	NOUN
dti-2103	57	30	and	and	CCONJ
dti-2103	57	31	untreated	untreated	ADJ
dti-2103	57	32	cells	cell	NOUN
dti-2103	57	33	were	be	AUX
dti-2103	57	34	taken	take	VERB
dti-2103	57	35	as	as	ADP
dti-2103	57	36	control	control	NOUN
dti-2103	57	37	.	.	PUNCT
dti-2103	58	1	total	total	ADJ
dti-2103	58	2	protein	protein	NOUN
dti-2103	58	3	was	be	AUX
dti-2103	58	4	extracted	extract	VERB
dti-2103	58	5	from	from	ADP
dti-2103	58	6	cell	cell	NOUN
dti-2103	58	7	pellet	pellet	NOUN
dti-2103	58	8	by	by	ADP
dti-2103	58	9	sonication	sonication	NOUN
dti-2103	58	10	(	(	PUNCT
dti-2103	58	11	3	3	NUM
dti-2103	58	12	minutes	minute	NOUN
dti-2103	58	13	:	:	PUNCT
dti-2103	58	14	pulse	pulse	VERB
dti-2103	58	15	30	30	NUM
dti-2103	58	16	seconds	second	NOUN
dti-2103	58	17	on	on	ADP
dti-2103	58	18	,	,	PUNCT
dti-2103	58	19	30	30	NUM
dti-2103	58	20	seconds	second	NOUN
dti-2103	58	21	off	off	ADV
dti-2103	58	22	)	)	PUNCT
dti-2103	58	23	in	in	ADP
dti-2103	58	24	ice	ice	NOUN
dti-2103	58	25	-	-	PUNCT
dti-2103	58	26	chilled	chill	VERB
dti-2103	58	27	pbs	pbs	NOUN
dti-2103	58	28	and	and	CCONJ
dti-2103	58	29	was	be	AUX
dti-2103	58	30	quantitated	quantitate	VERB
dti-2103	58	31	.	.	PUNCT
dti-2103	59	1	samples	sample	NOUN
dti-2103	59	2	were	be	AUX
dti-2103	59	3	electrophoresed	electrophorese	VERB
dti-2103	59	4	in	in	ADP
dti-2103	59	5	10	10	NUM
dti-2103	59	6	%	%	NOUN
dti-2103	59	7	sodium	sodium	NOUN
dti-2103	59	8	dodecyl	dodecyl	NOUN
dti-2103	59	9	sulfate	sulfate	NOUN
dti-2103	59	10	-	-	PUNCT
dti-2103	59	11	polyacrylamide	polyacrylamide	NOUN
dti-2103	59	12	gel	gel	NOUN
dti-2103	59	13	electrophoresis	electrophoresis	NOUN
dti-2103	59	14	(	(	PUNCT
dti-2103	59	15	sds	sds	NOUN
dti-2103	59	16	-	-	PUNCT
dti-2103	59	17	page	page	NOUN
dti-2103	59	18	)	)	PUNCT
dti-2103	59	19	and	and	CCONJ
dti-2103	59	20	separated	separate	VERB
dti-2103	59	21	proteins	protein	NOUN
dti-2103	59	22	were	be	AUX
dti-2103	59	23	transferred	transfer	VERB
dti-2103	59	24	onto	onto	ADP
dti-2103	59	25	polyvinylidene	polyvinylidene	NOUN
dti-2103	59	26	difluoride	difluoride	NOUN
dti-2103	59	27	(	(	PUNCT
dti-2103	59	28	pvdf	pvdf	NOUN
dti-2103	59	29	)	)	PUNCT
dti-2103	59	30	membrane	membrane	NOUN
dti-2103	59	31	.	.	PUNCT
dti-2103	60	1	membranes	membrane	NOUN
dti-2103	60	2	were	be	AUX
dti-2103	60	3	processed	process	VERB
dti-2103	60	4	and	and	CCONJ
dti-2103	60	5	incubated	incubate	VERB
dti-2103	60	6	with	with	ADP
dti-2103	60	7	anti	anti	ADJ
dti-2103	60	8	-	-	ADJ
dti-2103	60	9	ugp2	ugp2	ADJ
dti-2103	60	10	antibody	antibody	NOUN
dti-2103	60	11	(	(	PUNCT
dti-2103	60	12	1:2,000	1:2,000	NUM
dti-2103	60	13	,	,	PUNCT
dti-2103	60	14	abcam	abcam	PROPN
dti-2103	60	15	)	)	PUNCT
dti-2103	60	16	for	for	ADP
dti-2103	60	17	3	3	NUM
dti-2103	60	18	hours	hour	NOUN
dti-2103	60	19	at	at	ADP
dti-2103	60	20	37	37	NUM
dti-2103	60	21	°	°	NOUN
dti-2103	60	22	c	c	NOUN
dti-2103	60	23	followed	follow	VERB
dti-2103	60	24	by	by	ADP
dti-2103	60	25	treatment	treatment	NOUN
dti-2103	60	26	with	with	ADP
dti-2103	60	27	horseradish	horseradish	ADJ
dti-2103	60	28	peroxidase	peroxidase	NOUN
dti-2103	60	29	(	(	PUNCT
dti-2103	60	30	hrp)-conjugated	hrp)-conjugated	ADJ
dti-2103	60	31	secondary	secondary	ADJ
dti-2103	60	32	antibody	antibody	NOUN
dti-2103	60	33	(	(	PUNCT
dti-2103	60	34	1:20,000	1:20,000	NUM
dti-2103	60	35	)	)	PUNCT
dti-2103	60	36	for	for	ADP
dti-2103	60	37	2	2	NUM
dti-2103	60	38	hours	hour	NOUN
dti-2103	60	39	at	at	ADP
dti-2103	60	40	37	37	NUM
dti-2103	60	41	°	°	NOUN
dti-2103	60	42	c	c	NOUN
dti-2103	60	43	.	.	PUNCT
dti-2103	61	1	pierce	pierce	PROPN
dti-2103	61	2	®	®	PROPN
dti-2103	61	3	ecl	ecl	PROPN
dti-2103	61	4	western	western	ADJ
dti-2103	61	5	blotting	blotting	ADJ
dti-2103	61	6	peroxidase	peroxidase	NOUN
dti-2103	61	7	substrate	substrate	NOUN
dti-2103	61	8	(	(	PUNCT
dti-2103	61	9	thermoscientific	thermoscientific	NOUN
dti-2103	61	10	)	)	PUNCT
dti-2103	61	11	was	be	AUX
dti-2103	61	12	used	use	VERB
dti-2103	61	13	for	for	ADP
dti-2103	61	14	developing	develop	VERB
dti-2103	61	15	protein	protein	NOUN
dti-2103	61	16	bands	band	NOUN
dti-2103	61	17	,	,	PUNCT
dti-2103	61	18	which	which	PRON
dti-2103	61	19	were	be	AUX
dti-2103	61	20	quantitated	quantitate	VERB
dti-2103	61	21	with	with	ADP
dti-2103	61	22	fluorchem	fluorchem	PROPN
dti-2103	61	23	m	m	PROPN
dti-2103	61	24	proteinsimple	proteinsimple	NOUN
dti-2103	61	25	(	(	PUNCT
dti-2103	61	26	bio	bio	NOUN
dti-2103	61	27	-	-	PUNCT
dti-2103	61	28	techne	techne	NOUN
dti-2103	61	29	)	)	PUNCT
dti-2103	61	30	.	.	PUNCT
dti-2103	62	1	gapdh	gapdh	NOUN
dti-2103	62	2	as	as	ADP
dti-2103	62	3	endogenous	endogenous	ADJ
dti-2103	62	4	control	control	NOUN
dti-2103	62	5	was	be	AUX
dti-2103	62	6	simultaneously	simultaneously	ADV
dti-2103	62	7	blotted	blot	VERB
dti-2103	62	8	and	and	CCONJ
dti-2103	62	9	analyzed	analyze	VERB
dti-2103	62	10	.	.	PUNCT
dti-2103	63	1	expression	expression	NOUN
dti-2103	63	2	of	of	ADP
dti-2103	63	3	ugpase	ugpase	NOUN
dti-2103	63	4	was	be	AUX
dti-2103	63	5	normalized	normalize	VERB
dti-2103	63	6	with	with	ADP
dti-2103	63	7	the	the	DET
dti-2103	63	8	value	value	NOUN
dti-2103	63	9	of	of	ADP
dti-2103	63	10	gapdh	gapdh	NOUN
dti-2103	63	11	in	in	ADP
dti-2103	63	12	each	each	DET
dti-2103	63	13	sample	sample	NOUN
dti-2103	63	14	.	.	PUNCT
dti-2103	64	1	ugpase	ugpase	NOUN
dti-2103	64	2	-	-	PUNCT
dti-2103	64	3	mediated	mediate	VERB
dti-2103	64	4	streptococcus	streptococcus	NOUN
dti-2103	64	5	pneumoniae	pneumoniae	ADJ
dti-2103	64	6	virulence28	virulence28	NOUN
dti-2103	64	7	©	©	ADP
dti-2103	64	8	2020	2020	NUM
dti-2103	65	1	the	the	DET
dti-2103	65	2	authors	author	NOUN
dti-2103	65	3	.	.	PUNCT
dti-2103	65	4	published	publish	VERB
dti-2103	65	5	by	by	ADP
dti-2103	65	6	aboutscience	aboutscience	NOUN
dti-2103	65	7	adherence	adherence	NOUN
dti-2103	65	8	assay	assay	NOUN
dti-2103	65	9	efficacy	efficacy	NOUN
dti-2103	65	10	of	of	ADP
dti-2103	65	11	udp	udp	NOUN
dti-2103	65	12	to	to	PART
dti-2103	65	13	inhibit	inhibit	VERB
dti-2103	65	14	the	the	DET
dti-2103	65	15	adherence	adherence	NOUN
dti-2103	65	16	of	of	ADP
dti-2103	65	17	s.	s.	PROPN
dti-2103	65	18	pneumoniae	pneumoniae	ADJ
dti-2103	65	19	during	during	ADP
dti-2103	65	20	infection	infection	NOUN
dti-2103	65	21	with	with	ADP
dti-2103	65	22	a549	a549	PROPN
dti-2103	65	23	and	and	CCONJ
dti-2103	65	24	hep-2	hep-2	PUNCT
dti-2103	65	25	monolayers	monolayer	NOUN
dti-2103	65	26	was	be	AUX
dti-2103	65	27	checked	check	VERB
dti-2103	65	28	by	by	ADP
dti-2103	65	29	flow	flow	NOUN
dti-2103	65	30	cytometer	cytometer	NOUN
dti-2103	65	31	(	(	PUNCT
dti-2103	65	32	bd	bd	PROPN
dti-2103	65	33	biosciences	bioscience	NOUN
dti-2103	65	34	)	)	PUNCT
dti-2103	65	35	(	(	PUNCT
dti-2103	65	36	25	25	NUM
dti-2103	65	37	)	)	PUNCT
dti-2103	65	38	.	.	PUNCT
dti-2103	66	1	log	log	NOUN
dti-2103	66	2	phase	phase	NOUN
dti-2103	66	3	cultures	culture	NOUN
dti-2103	66	4	of	of	ADP
dti-2103	66	5	pneumococcus	pneumococcus	NOUN
dti-2103	66	6	were	be	AUX
dti-2103	66	7	labeled	label	VERB
dti-2103	66	8	with	with	ADP
dti-2103	66	9	fluorescein	fluorescein	ADJ
dti-2103	66	10	isothiocyanate	isothiocyanate	NOUN
dti-2103	66	11	(	(	PUNCT
dti-2103	66	12	fitc	fitc	PROPN
dti-2103	66	13	,	,	PUNCT
dti-2103	66	14	1.0	1.0	NUM
dti-2103	66	15	μg	μg	PROPN
dti-2103	66	16	/	/	SYM
dti-2103	66	17	μl	μl	PROPN
dti-2103	66	18	)	)	PUNCT
dti-2103	66	19	and	and	CCONJ
dti-2103	66	20	infected	infect	VERB
dti-2103	66	21	onto	onto	ADP
dti-2103	66	22	monolayers	monolayer	NOUN
dti-2103	66	23	at	at	ADP
dti-2103	66	24	100:1	100:1	NUM
dti-2103	66	25	multiplicity	multiplicity	NOUN
dti-2103	66	26	of	of	ADP
dti-2103	66	27	infection	infection	NOUN
dti-2103	66	28	(	(	PUNCT
dti-2103	66	29	moi	moi	PROPN
dti-2103	66	30	:	:	PUNCT
dti-2103	66	31	bacteria	bacteria	NOUN
dti-2103	66	32	/	/	SYM
dti-2103	66	33	cell	cell	NOUN
dti-2103	66	34	)	)	PUNCT
dti-2103	66	35	in	in	ADP
dti-2103	66	36	the	the	DET
dti-2103	66	37	presence	presence	NOUN
dti-2103	66	38	and	and	CCONJ
dti-2103	66	39	absence	absence	NOUN
dti-2103	66	40	of	of	ADP
dti-2103	66	41	inhibitor	inhibitor	NOUN
dti-2103	66	42	at	at	ADP
dti-2103	66	43	effective	effective	ADJ
dti-2103	66	44	dose	dose	NOUN
dti-2103	66	45	.	.	PUNCT
dti-2103	67	1	monolayers	monolayer	NOUN
dti-2103	67	2	were	be	AUX
dti-2103	67	3	incubated	incubate	VERB
dti-2103	67	4	at	at	ADP
dti-2103	67	5	37	37	NUM
dti-2103	67	6	°	°	NOUN
dti-2103	67	7	c	c	NOUN
dti-2103	67	8	at	at	ADP
dti-2103	67	9	5	5	NUM
dti-2103	67	10	%	%	NOUN
dti-2103	67	11	co2	co2	NOUN
dti-2103	67	12	for	for	ADP
dti-2103	67	13	2	2	NUM
dti-2103	67	14	hours	hour	NOUN
dti-2103	67	15	followed	follow	VERB
dti-2103	67	16	by	by	ADP
dti-2103	67	17	trypsinization	trypsinization	NOUN
dti-2103	67	18	(	(	PUNCT
dti-2103	67	19	0.05	0.05	NUM
dti-2103	67	20	%	%	NOUN
dti-2103	67	21	)	)	PUNCT
dti-2103	67	22	and	and	CCONJ
dti-2103	67	23	fixation	fixation	NOUN
dti-2103	67	24	with	with	ADP
dti-2103	67	25	ice	ice	NOUN
dti-2103	67	26	-	-	PUNCT
dti-2103	67	27	cold	cold	ADJ
dti-2103	67	28	paraformaldehyde	paraformaldehyde	NOUN
dti-2103	67	29	(	(	PUNCT
dti-2103	67	30	2	2	NUM
dti-2103	67	31	%	%	NOUN
dti-2103	67	32	)	)	PUNCT
dti-2103	67	33	.	.	PUNCT
dti-2103	68	1	samples	sample	NOUN
dti-2103	68	2	were	be	AUX
dti-2103	68	3	analyzed	analyze	VERB
dti-2103	68	4	using	use	VERB
dti-2103	68	5	facscan	facscan	ADJ
dti-2103	68	6	flow	flow	NOUN
dti-2103	68	7	cytometer	cytometer	NOUN
dti-2103	68	8	using	use	VERB
dti-2103	68	9	cellquest	cellquest	VERB
dti-2103	68	10	3.3	3.3	NUM
dti-2103	68	11	software	software	NOUN
dti-2103	68	12	(	(	PUNCT
dti-2103	68	13	bd	bd	PROPN
dti-2103	68	14	biosciences	bioscience	NOUN
dti-2103	68	15	)	)	PUNCT
dti-2103	68	16	.	.	PUNCT
dti-2103	69	1	mean	mean	VERB
dti-2103	69	2	fluorescence	fluorescence	NOUN
dti-2103	69	3	intensity	intensity	NOUN
dti-2103	69	4	(	(	PUNCT
dti-2103	69	5	mfi	mfi	PROPN
dti-2103	69	6	)	)	PUNCT
dti-2103	69	7	values	value	NOUN
dti-2103	69	8	were	be	AUX
dti-2103	69	9	obtained	obtain	VERB
dti-2103	69	10	from	from	ADP
dti-2103	69	11	control	control	NOUN
dti-2103	69	12	samples	sample	NOUN
dti-2103	69	13	(	(	PUNCT
dti-2103	69	14	unlabeled	unlabele	VERB
dti-2103	69	15	host	host	NOUN
dti-2103	69	16	cells	cell	NOUN
dti-2103	69	17	and	and	CCONJ
dti-2103	69	18	bacteria	bacteria	NOUN
dti-2103	69	19	)	)	PUNCT
dti-2103	69	20	.	.	PUNCT
dti-2103	70	1	adherence	adherence	NOUN
dti-2103	70	2	was	be	AUX
dti-2103	70	3	calculated	calculate	VERB
dti-2103	70	4	from	from	ADP
dti-2103	70	5	the	the	DET
dti-2103	70	6	mfi	mfi	PROPN
dti-2103	70	7	of	of	ADP
dti-2103	70	8	host	host	NOUN
dti-2103	70	9	cell	cell	NOUN
dti-2103	70	10	with	with	ADP
dti-2103	70	11	adherent	adherent	ADJ
dti-2103	70	12	pneumococci	pneumococci	NOUN
dti-2103	70	13	divided	divide	VERB
dti-2103	70	14	by	by	ADP
dti-2103	70	15	mfi	mfi	PROPN
dti-2103	70	16	of	of	ADP
dti-2103	70	17	labeled	label	VERB
dti-2103	70	18	pneumococci	pneumococci	NOUN
dti-2103	70	19	.	.	PUNCT
dti-2103	71	1	effectiveness	effectiveness	NOUN
dti-2103	71	2	of	of	ADP
dti-2103	71	3	inhibitor	inhibitor	NOUN
dti-2103	71	4	was	be	AUX
dti-2103	71	5	evaluated	evaluate	VERB
dti-2103	71	6	from	from	ADP
dti-2103	71	7	the	the	DET
dti-2103	71	8	adherence	adherence	NOUN
dti-2103	71	9	potential	potential	NOUN
dti-2103	71	10	of	of	ADP
dti-2103	71	11	s.	s.	PROPN
dti-2103	71	12	pneumoniae	pneumoniae	ADJ
dti-2103	71	13	to	to	ADP
dti-2103	71	14	monolayers	monolayer	NOUN
dti-2103	71	15	in	in	ADP
dti-2103	71	16	the	the	DET
dti-2103	71	17	presence	presence	NOUN
dti-2103	71	18	of	of	ADP
dti-2103	71	19	inhibitor	inhibitor	NOUN
dti-2103	71	20	.	.	PUNCT
dti-2103	72	1	phagocytosis	phagocytosis	NOUN
dti-2103	72	2	assay	assay	PROPN
dti-2103	72	3	fitc	fitc	NOUN
dti-2103	72	4	-	-	PUNCT
dti-2103	72	5	labeled	label	VERB
dti-2103	72	6	pneumococci	pneumococci	NOUN
dti-2103	72	7	were	be	AUX
dti-2103	72	8	loaded	load	VERB
dti-2103	72	9	(	(	PUNCT
dti-2103	72	10	moi	moi	X
dti-2103	72	11	,	,	PUNCT
dti-2103	72	12	100:1	100:1	NUM
dti-2103	72	13	)	)	PUNCT
dti-2103	72	14	onto	onto	ADP
dti-2103	72	15	macrophage	macrophage	ADJ
dti-2103	72	16	cells	cell	NOUN
dti-2103	72	17	(	(	PUNCT
dti-2103	72	18	thp1	thp1	NOUN
dti-2103	72	19	and	and	CCONJ
dti-2103	72	20	j774.a.1	j774.a.1	PROPN
dti-2103	72	21	)	)	PUNCT
dti-2103	72	22	in	in	ADP
dti-2103	72	23	the	the	DET
dti-2103	72	24	presence	presence	NOUN
dti-2103	72	25	and	and	CCONJ
dti-2103	72	26	absence	absence	NOUN
dti-2103	72	27	of	of	ADP
dti-2103	72	28	udp	udp	NOUN
dti-2103	72	29	for	for	ADP
dti-2103	72	30	1	1	NUM
dti-2103	72	31	hour	hour	NOUN
dti-2103	72	32	at	at	ADP
dti-2103	72	33	37	37	NUM
dti-2103	72	34	°	°	NOUN
dti-2103	72	35	c	c	NOUN
dti-2103	72	36	in	in	ADP
dti-2103	72	37	5	5	NUM
dti-2103	72	38	%	%	NOUN
dti-2103	72	39	co2	co2	NOUN
dti-2103	72	40	.	.	PUNCT
dti-2103	73	1	cells	cell	NOUN
dti-2103	73	2	were	be	AUX
dti-2103	73	3	fixed	fix	VERB
dti-2103	73	4	with	with	ADP
dti-2103	73	5	cold	cold	ADJ
dti-2103	73	6	2	2	NUM
dti-2103	73	7	%	%	NOUN
dti-2103	73	8	paraformaldehyde	paraformaldehyde	NOUN
dti-2103	73	9	.	.	PUNCT
dti-2103	74	1	briefly	briefly	ADV
dti-2103	74	2	,	,	PUNCT
dti-2103	74	3	cells	cell	NOUN
dti-2103	74	4	were	be	AUX
dti-2103	74	5	collected	collect	VERB
dti-2103	74	6	,	,	PUNCT
dti-2103	74	7	centrifuged	centrifuge	VERB
dti-2103	74	8	,	,	PUNCT
dti-2103	74	9	washed	wash	VERB
dti-2103	74	10	as	as	SCONJ
dti-2103	74	11	required	require	VERB
dti-2103	74	12	,	,	PUNCT
dti-2103	74	13	and	and	CCONJ
dti-2103	74	14	were	be	AUX
dti-2103	74	15	suspended	suspend	VERB
dti-2103	74	16	in	in	ADP
dti-2103	74	17	icecold	icecold	PROPN
dti-2103	74	18	pbs	pbs	PROPN
dti-2103	74	19	.	.	PUNCT
dti-2103	75	1	trypan	trypan	PROPN
dti-2103	75	2	blue	blue	NOUN
dti-2103	75	3	(	(	PUNCT
dti-2103	75	4	0.2	0.2	NUM
dti-2103	75	5	%	%	NOUN
dti-2103	75	6	)	)	PUNCT
dti-2103	75	7	was	be	AUX
dti-2103	75	8	added	add	VERB
dti-2103	75	9	to	to	PART
dti-2103	75	10	quench	quench	VERB
dti-2103	75	11	fluorescence	fluorescence	NOUN
dti-2103	75	12	of	of	ADP
dti-2103	75	13	extracellularly	extracellularly	ADV
dti-2103	75	14	attached	attach	VERB
dti-2103	75	15	pneumococci	pneumococci	NOUN
dti-2103	75	16	,	,	PUNCT
dti-2103	75	17	just	just	ADV
dti-2103	75	18	before	before	ADP
dti-2103	75	19	analysis	analysis	NOUN
dti-2103	75	20	in	in	ADP
dti-2103	75	21	flow	flow	NOUN
dti-2103	75	22	cytometer	cytometer	NOUN
dti-2103	75	23	(	(	PUNCT
dti-2103	75	24	bd	bd	PROPN
dti-2103	75	25	biosciences	bioscience	NOUN
dti-2103	75	26	)	)	PUNCT
dti-2103	75	27	.	.	PUNCT
dti-2103	76	1	mfi	mfi	PROPN
dti-2103	76	2	of	of	ADP
dti-2103	76	3	fitc	fitc	PROPN
dti-2103	76	4	positive	positive	ADJ
dti-2103	76	5	cells	cell	NOUN
dti-2103	76	6	was	be	AUX
dti-2103	76	7	calculated	calculate	VERB
dti-2103	76	8	to	to	PART
dti-2103	76	9	assess	assess	VERB
dti-2103	76	10	the	the	DET
dti-2103	76	11	phagocytic	phagocytic	ADJ
dti-2103	76	12	activity	activity	NOUN
dti-2103	76	13	in	in	ADP
dti-2103	76	14	comparison	comparison	NOUN
dti-2103	76	15	to	to	ADP
dti-2103	76	16	controls	control	NOUN
dti-2103	76	17	(	(	PUNCT
dti-2103	76	18	unlabeled	unlabele	VERB
dti-2103	76	19	cells	cell	NOUN
dti-2103	76	20	and	and	CCONJ
dti-2103	76	21	bacteria	bacteria	NOUN
dti-2103	76	22	)	)	PUNCT
dti-2103	76	23	.	.	PUNCT
dti-2103	77	1	for	for	ADP
dti-2103	77	2	opsonophagocytic	opsonophagocytic	ADJ
dti-2103	77	3	assay	assay	NOUN
dti-2103	77	4	(	(	PUNCT
dti-2103	77	5	opa	opa	NOUN
dti-2103	77	6	)	)	PUNCT
dti-2103	77	7	,	,	PUNCT
dti-2103	77	8	bacterial	bacterial	ADJ
dti-2103	77	9	cells	cell	NOUN
dti-2103	77	10	(	(	PUNCT
dti-2103	77	11	106	106	NUM
dti-2103	77	12	cfu/	cfu/	VERB
dti-2103	77	13	ml	ml	NOUN
dti-2103	77	14	)	)	PUNCT
dti-2103	77	15	were	be	AUX
dti-2103	77	16	labeled	label	VERB
dti-2103	77	17	with	with	ADP
dti-2103	77	18	fitc	fitc	PROPN
dti-2103	77	19	(	(	PUNCT
dti-2103	77	20	1	1	NUM
dti-2103	77	21	μg	μg	PROPN
dti-2103	77	22	/	/	SYM
dti-2103	77	23	μl	μl	NOUN
dti-2103	77	24	)	)	PUNCT
dti-2103	77	25	after	after	ADP
dti-2103	77	26	inactivation	inactivation	NOUN
dti-2103	77	27	at	at	ADP
dti-2103	77	28	95	95	NUM
dti-2103	77	29	°	°	ADP
dti-2103	77	30	c	c	NOUN
dti-2103	77	31	for	for	ADP
dti-2103	77	32	5	5	NUM
dti-2103	77	33	minutes	minute	NOUN
dti-2103	77	34	.	.	PUNCT
dti-2103	78	1	nonviability	nonviability	PROPN
dti-2103	78	2	was	be	AUX
dti-2103	78	3	confirmed	confirm	VERB
dti-2103	78	4	by	by	ADP
dti-2103	78	5	overnight	overnight	ADJ
dti-2103	78	6	incubation	incubation	NOUN
dti-2103	78	7	of	of	ADP
dti-2103	78	8	blood	blood	NOUN
dti-2103	78	9	agar	agar	NOUN
dti-2103	78	10	plates	plate	NOUN
dti-2103	78	11	streaked	streak	VERB
dti-2103	78	12	with	with	ADP
dti-2103	78	13	bacterial	bacterial	ADJ
dti-2103	78	14	suspension	suspension	NOUN
dti-2103	78	15	(	(	PUNCT
dti-2103	78	16	100	100	NUM
dti-2103	78	17	μl	μl	NUM
dti-2103	78	18	)	)	PUNCT
dti-2103	78	19	.	.	PUNCT
dti-2103	79	1	labeled	label	VERB
dti-2103	79	2	bacteria	bacteria	NOUN
dti-2103	79	3	were	be	AUX
dti-2103	79	4	incubated	incubate	VERB
dti-2103	79	5	with	with	ADP
dti-2103	79	6	pooled	pool	VERB
dti-2103	79	7	human	human	ADJ
dti-2103	79	8	sera	sera	NOUN
dti-2103	79	9	(	(	PUNCT
dti-2103	79	10	10	10	NUM
dti-2103	79	11	%	%	NOUN
dti-2103	79	12	of	of	ADP
dti-2103	79	13	1:2	1:2	NUM
dti-2103	79	14	diluted	dilute	VERB
dti-2103	79	15	in	in	ADP
dti-2103	79	16	pbs	pbs	PROPN
dti-2103	79	17	)	)	PUNCT
dti-2103	79	18	for	for	ADP
dti-2103	79	19	30	30	NUM
dti-2103	79	20	minutes	minute	NOUN
dti-2103	79	21	at	at	ADP
dti-2103	79	22	37	37	NUM
dti-2103	79	23	°	°	NOUN
dti-2103	79	24	c	c	NOUN
dti-2103	79	25	,	,	PUNCT
dti-2103	79	26	150	150	NUM
dti-2103	79	27	rpm	rpm	NOUN
dti-2103	79	28	.	.	PUNCT
dti-2103	80	1	bacteria	bacteria	NOUN
dti-2103	80	2	were	be	AUX
dti-2103	80	3	further	far	ADV
dti-2103	80	4	inoculated	inoculate	VERB
dti-2103	80	5	onto	onto	ADP
dti-2103	80	6	thp1	thp1	NOUN
dti-2103	80	7	and	and	CCONJ
dti-2103	80	8	j774.a.1	j774.a.1	PROPN
dti-2103	80	9	cells	cell	NOUN
dti-2103	80	10	at	at	ADP
dti-2103	80	11	moi	moi	PROPN
dti-2103	80	12	100:1	100:1	NUM
dti-2103	80	13	for	for	ADP
dti-2103	80	14	1	1	NUM
dti-2103	80	15	hour	hour	NOUN
dti-2103	80	16	at	at	ADP
dti-2103	80	17	37	37	NUM
dti-2103	80	18	°	°	NOUN
dti-2103	80	19	c	c	NOUN
dti-2103	80	20	and	and	CCONJ
dti-2103	80	21	5	5	NUM
dti-2103	80	22	%	%	NOUN
dti-2103	80	23	co2	co2	NOUN
dti-2103	80	24	.	.	PUNCT
dti-2103	81	1	control	control	NOUN
dti-2103	81	2	tubes	tube	NOUN
dti-2103	81	3	contained	contain	VERB
dti-2103	81	4	pbs	pbs	PROPN
dti-2103	81	5	or	or	CCONJ
dti-2103	81	6	heat	heat	NOUN
dti-2103	81	7	-	-	PUNCT
dti-2103	81	8	inactivated	inactivate	VERB
dti-2103	81	9	(	(	PUNCT
dti-2103	81	10	56	56	NUM
dti-2103	81	11	°	°	NOUN
dti-2103	81	12	c	c	NOUN
dti-2103	81	13	for	for	ADP
dti-2103	81	14	45	45	NUM
dti-2103	81	15	minutes	minute	NOUN
dti-2103	81	16	)	)	PUNCT
dti-2103	81	17	pooled	pool	VERB
dti-2103	81	18	sera	sera	NOUN
dti-2103	81	19	.	.	PUNCT
dti-2103	82	1	the	the	DET
dti-2103	82	2	cells	cell	NOUN
dti-2103	82	3	were	be	AUX
dti-2103	82	4	obtained	obtain	VERB
dti-2103	82	5	,	,	PUNCT
dti-2103	82	6	washed	wash	VERB
dti-2103	82	7	,	,	PUNCT
dti-2103	82	8	centrifuged	centrifuge	VERB
dti-2103	82	9	,	,	PUNCT
dti-2103	82	10	and	and	CCONJ
dti-2103	82	11	fixed	fix	VERB
dti-2103	82	12	with	with	ADP
dti-2103	82	13	cold	cold	ADJ
dti-2103	82	14	2	2	NUM
dti-2103	82	15	%	%	NOUN
dti-2103	82	16	paraformaldehyde	paraformaldehyde	NOUN
dti-2103	82	17	and	and	CCONJ
dti-2103	82	18	analyzed	analyze	VERB
dti-2103	82	19	in	in	ADP
dti-2103	82	20	a	a	DET
dti-2103	82	21	flow	flow	NOUN
dti-2103	82	22	cytometer	cytometer	NOUN
dti-2103	82	23	(	(	PUNCT
dti-2103	82	24	26	26	NUM
dti-2103	82	25	)	)	PUNCT
dti-2103	82	26	.	.	PUNCT
dti-2103	83	1	expression	expression	NOUN
dti-2103	83	2	of	of	ADP
dti-2103	83	3	postinfection	postinfection	NOUN
dti-2103	83	4	cytokines	cytokine	VERB
dti-2103	83	5	a549	a549	PROPN
dti-2103	83	6	monolayers	monolayer	NOUN
dti-2103	83	7	were	be	AUX
dti-2103	83	8	incubated	incubate	VERB
dti-2103	83	9	with	with	ADP
dti-2103	83	10	effective	effective	ADJ
dti-2103	83	11	dose	dose	NOUN
dti-2103	83	12	of	of	ADP
dti-2103	83	13	udp	udp	NOUN
dti-2103	83	14	for	for	ADP
dti-2103	83	15	1	1	NUM
dti-2103	83	16	hour	hour	NOUN
dti-2103	83	17	at	at	ADP
dti-2103	83	18	37	37	NUM
dti-2103	83	19	°	°	NOUN
dti-2103	83	20	c	c	NOUN
dti-2103	83	21	,	,	PUNCT
dti-2103	83	22	5	5	NUM
dti-2103	83	23	%	%	NOUN
dti-2103	83	24	co2	co2	NOUN
dti-2103	83	25	.	.	PUNCT
dti-2103	84	1	in	in	ADP
dti-2103	84	2	another	another	DET
dti-2103	84	3	set	set	NOUN
dti-2103	84	4	,	,	PUNCT
dti-2103	84	5	monolayers	monolayer	NOUN
dti-2103	84	6	were	be	AUX
dti-2103	84	7	treated	treat	VERB
dti-2103	84	8	with	with	ADP
dti-2103	84	9	10	10	NUM
dti-2103	84	10	μm	μm	NUM
dti-2103	84	11	mrs2578	mrs2578	NOUN
dti-2103	84	12	for	for	ADP
dti-2103	84	13	30	30	NUM
dti-2103	84	14	minutes	minute	NOUN
dti-2103	84	15	before	before	ADP
dti-2103	84	16	incubation	incubation	NOUN
dti-2103	84	17	with	with	ADP
dti-2103	84	18	udp	udp	NOUN
dti-2103	84	19	(	(	PUNCT
dti-2103	84	20	27	27	NUM
dti-2103	84	21	)	)	PUNCT
dti-2103	84	22	.	.	PUNCT
dti-2103	85	1	total	total	ADJ
dti-2103	85	2	ribonucleic	ribonucleic	ADJ
dti-2103	85	3	acid	acid	NOUN
dti-2103	85	4	(	(	PUNCT
dti-2103	85	5	rna	rna	PROPN
dti-2103	85	6	)	)	PUNCT
dti-2103	85	7	was	be	AUX
dti-2103	85	8	extracted	extract	VERB
dti-2103	85	9	from	from	ADP
dti-2103	85	10	trypsinized	trypsinize	VERB
dti-2103	85	11	cell	cell	NOUN
dti-2103	85	12	pellets	pellet	NOUN
dti-2103	85	13	using	use	VERB
dti-2103	85	14	trizol	trizol	PROPN
dti-2103	85	15	reagent	reagent	NOUN
dti-2103	85	16	followed	follow	VERB
dti-2103	85	17	by	by	ADP
dti-2103	85	18	complementary	complementary	ADJ
dti-2103	85	19	deoxyribonucleic	deoxyribonucleic	ADJ
dti-2103	85	20	acid	acid	NOUN
dti-2103	85	21	(	(	PUNCT
dti-2103	85	22	cdna	cdna	PROPN
dti-2103	85	23	)	)	PUNCT
dti-2103	85	24	synthesis	synthesis	NOUN
dti-2103	85	25	using	use	VERB
dti-2103	85	26	messenger	messenger	PROPN
dti-2103	85	27	rna	rna	PROPN
dti-2103	85	28	revertaid	revertaid	VERB
dti-2103	85	29	™	™	PROPN
dti-2103	85	30	first	first	ADJ
dti-2103	85	31	strand	strand	NOUN
dti-2103	85	32	cdna	cdna	PROPN
dti-2103	85	33	synthesis	synthesis	NOUN
dti-2103	85	34	kit	kit	NOUN
dti-2103	85	35	(	(	PUNCT
dti-2103	85	36	thermo	thermo	NOUN
dti-2103	85	37	scientific	scientific	NOUN
dti-2103	85	38	)	)	PUNCT
dti-2103	85	39	.	.	PUNCT
dti-2103	86	1	expression	expression	NOUN
dti-2103	86	2	of	of	ADP
dti-2103	86	3	various	various	ADJ
dti-2103	86	4	cytokines	cytokine	NOUN
dti-2103	86	5	(	(	PUNCT
dti-2103	86	6	interleukin	interleukin	NOUN
dti-2103	86	7	[	[	X
dti-2103	86	8	il]-6	il]-6	ADV
dti-2103	86	9	,	,	PUNCT
dti-2103	86	10	il-1β	il-1β	PROPN
dti-2103	86	11	,	,	PUNCT
dti-2103	86	12	il-8	il-8	NOUN
dti-2103	86	13	,	,	PUNCT
dti-2103	86	14	tumor	tumor	NOUN
dti-2103	86	15	necrosis	necrosis	NOUN
dti-2103	86	16	factor	factor	NOUN
dti-2103	86	17	[	[	X
dti-2103	86	18	tnf]-α	tnf]-α	NOUN
dti-2103	86	19	)	)	PUNCT
dti-2103	86	20	was	be	AUX
dti-2103	86	21	analyzed	analyze	VERB
dti-2103	86	22	using	use	VERB
dti-2103	86	23	real	real	ADJ
dti-2103	86	24	-	-	PUNCT
dti-2103	86	25	time	time	NOUN
dti-2103	86	26	polymerase	polymerase	NOUN
dti-2103	86	27	chain	chain	NOUN
dti-2103	86	28	reaction	reaction	NOUN
dti-2103	86	29	(	(	PUNCT
dti-2103	86	30	pcr	pcr	PROPN
dti-2103	86	31	;	;	PUNCT
dti-2103	86	32	roche	roche	PROPN
dti-2103	86	33	lightcycler	lightcycler	PROPN
dti-2103	86	34	®	®	PROPN
dti-2103	86	35	480	480	NUM
dti-2103	86	36	)	)	PUNCT
dti-2103	86	37	in	in	ADP
dti-2103	86	38	reactions	reaction	NOUN
dti-2103	86	39	(	(	PUNCT
dti-2103	86	40	10	10	NUM
dti-2103	86	41	μl	μl	VERB
dti-2103	86	42	)	)	PUNCT
dti-2103	86	43	containing	contain	VERB
dti-2103	86	44	50	50	NUM
dti-2103	86	45	ng	ng	PROPN
dti-2103	86	46	cdna	cdna	PROPN
dti-2103	86	47	,	,	PUNCT
dti-2103	86	48	0.5	0.5	NUM
dti-2103	86	49	μm	μm	NUM
dti-2103	86	50	primer	primer	NOUN
dti-2103	86	51	,	,	PUNCT
dti-2103	86	52	1x	1x	NUM
dti-2103	86	53	sybr	sybr	NOUN
dti-2103	86	54	mix	mix	PROPN
dti-2103	86	55	,	,	PUNCT
dti-2103	86	56	and	and	CCONJ
dti-2103	86	57	deionized	deionize	VERB
dti-2103	86	58	water	water	NOUN
dti-2103	86	59	.	.	PUNCT
dti-2103	87	1	gene	gene	NOUN
dti-2103	87	2	-	-	PUNCT
dti-2103	87	3	specific	specific	ADJ
dti-2103	87	4	primers	primer	NOUN
dti-2103	87	5	were	be	AUX
dti-2103	87	6	designed	design	VERB
dti-2103	87	7	using	use	VERB
dti-2103	87	8	primer3tool	primer3tool	NOUN
dti-2103	87	9	and	and	CCONJ
dti-2103	87	10	pcrs	pcrs	NOUN
dti-2103	87	11	were	be	AUX
dti-2103	87	12	run	run	VERB
dti-2103	87	13	in	in	ADP
dti-2103	87	14	primer	primer	NOUN
dti-2103	87	15	-	-	PUNCT
dti-2103	87	16	specific	specific	ADJ
dti-2103	87	17	cycling	cycling	NOUN
dti-2103	87	18	conditions	condition	NOUN
dti-2103	87	19	and	and	CCONJ
dti-2103	87	20	with	with	ADP
dti-2103	87	21	appropriate	appropriate	ADJ
dti-2103	87	22	negative	negative	ADJ
dti-2103	87	23	controls	control	NOUN
dti-2103	87	24	for	for	ADP
dti-2103	87	25	each	each	DET
dti-2103	87	26	reaction	reaction	NOUN
dti-2103	87	27	.	.	PUNCT
dti-2103	88	1	statistical	statistical	ADJ
dti-2103	88	2	analysis	analysis	NOUN
dti-2103	88	3	each	each	DET
dti-2103	88	4	experiment	experiment	NOUN
dti-2103	88	5	was	be	AUX
dti-2103	88	6	performed	perform	VERB
dti-2103	88	7	at	at	ADP
dti-2103	88	8	least	least	ADV
dti-2103	88	9	three	three	NUM
dti-2103	88	10	times	time	NOUN
dti-2103	88	11	in	in	ADP
dti-2103	88	12	duplicate	duplicate	NOUN
dti-2103	88	13	or	or	CCONJ
dti-2103	88	14	triplicate	triplicate	VERB
dti-2103	88	15	sets	set	NOUN
dti-2103	88	16	.	.	PUNCT
dti-2103	89	1	graphpad	graphpad	NOUN
dti-2103	89	2	prism	prism	NOUN
dti-2103	89	3	6.0	6.0	NUM
dti-2103	89	4	was	be	AUX
dti-2103	89	5	used	use	VERB
dti-2103	89	6	for	for	ADP
dti-2103	89	7	statistical	statistical	ADJ
dti-2103	89	8	calculations	calculation	NOUN
dti-2103	89	9	.	.	PUNCT
dti-2103	90	1	student	student	NOUN
dti-2103	90	2	’s	’s	PART
dti-2103	90	3	t	t	PROPN
dti-2103	90	4	-	-	PUNCT
dti-2103	90	5	test	test	NOUN
dti-2103	90	6	,	,	PUNCT
dti-2103	90	7	or	or	CCONJ
dti-2103	90	8	mann	mann	PROPN
dti-2103	90	9	-	-	PUNCT
dti-2103	90	10	whitney	whitney	PROPN
dti-2103	90	11	u	u	NOUN
dti-2103	90	12	-	-	NOUN
dti-2103	90	13	test	test	NOUN
dti-2103	90	14	or	or	CCONJ
dti-2103	90	15	analysis	analysis	NOUN
dti-2103	90	16	of	of	ADP
dti-2103	90	17	variance	variance	NOUN
dti-2103	90	18	(	(	PUNCT
dti-2103	90	19	anova	anova	PROPN
dti-2103	90	20	)	)	PUNCT
dti-2103	90	21	was	be	AUX
dti-2103	90	22	applied	apply	VERB
dti-2103	90	23	as	as	ADP
dti-2103	90	24	appropriate	appropriate	ADJ
dti-2103	90	25	.	.	PUNCT
dti-2103	91	1	a	a	DET
dti-2103	91	2	p	p	NOUN
dti-2103	91	3	value	value	NOUN
dti-2103	91	4	less	less	ADJ
dti-2103	91	5	than	than	ADP
dti-2103	91	6	0.05	0.05	NUM
dti-2103	91	7	was	be	AUX
dti-2103	91	8	considered	consider	VERB
dti-2103	91	9	to	to	PART
dti-2103	91	10	represent	represent	VERB
dti-2103	91	11	a	a	DET
dti-2103	91	12	significant	significant	ADJ
dti-2103	91	13	association	association	NOUN
dti-2103	91	14	.	.	PUNCT
dti-2103	92	1	results	result	VERB
dti-2103	92	2	putative	putative	ADJ
dti-2103	92	3	inhibitor	inhibitor	NOUN
dti-2103	92	4	of	of	ADP
dti-2103	92	5	ugpase	ugpase	VERB
dti-2103	92	6	the	the	DET
dti-2103	92	7	structure	structure	NOUN
dti-2103	92	8	of	of	ADP
dti-2103	92	9	s.	s.	PROPN
dti-2103	92	10	pneumoniae	pneumoniae	ADJ
dti-2103	92	11	ugpase	ugpase	NOUN
dti-2103	92	12	was	be	AUX
dti-2103	92	13	analyzed	analyze	VERB
dti-2103	92	14	in	in	ADP
dti-2103	92	15	silico	silico	NOUN
dti-2103	92	16	using	use	VERB
dti-2103	92	17	i	i	PROPN
dti-2103	92	18	-	-	PUNCT
dti-2103	92	19	tasser	tasser	NOUN
dti-2103	92	20	server	server	NOUN
dti-2103	92	21	(	(	PUNCT
dti-2103	92	22	http://zhang.bioinformatics	http://zhang.bioinformatic	NOUN
dti-2103	92	23	.	.	PUNCT
dti-2103	93	1	ku.edu/i-tasser	ku.edu/i-tasser	PROPN
dti-2103	93	2	;	;	PUNCT
dti-2103	93	3	phd	phd	NOUN
dti-2103	93	4	thesis	thesis	NOUN
dti-2103	93	5	)	)	PUNCT
dti-2103	93	6	.	.	PUNCT
dti-2103	94	1	the	the	DET
dti-2103	94	2	tertiary	tertiary	ADJ
dti-2103	94	3	structure	structure	NOUN
dti-2103	94	4	,	,	PUNCT
dti-2103	94	5	active	active	ADJ
dti-2103	94	6	site	site	NOUN
dti-2103	94	7	residues	residue	NOUN
dti-2103	94	8	,	,	PUNCT
dti-2103	94	9	and	and	CCONJ
dti-2103	94	10	its	its	PRON
dti-2103	94	11	substrate	substrate	NOUN
dti-2103	94	12	-	-	PUNCT
dti-2103	94	13	binding	bind	VERB
dti-2103	94	14	properties	property	NOUN
dti-2103	94	15	were	be	AUX
dti-2103	94	16	analyzed	analyze	VERB
dti-2103	94	17	.	.	PUNCT
dti-2103	95	1	the	the	DET
dti-2103	95	2	local	local	ADJ
dti-2103	95	3	conformational	conformational	ADJ
dti-2103	95	4	changes	change	NOUN
dti-2103	95	5	induced	induce	VERB
dti-2103	95	6	near	near	ADP
dti-2103	95	7	the	the	DET
dti-2103	95	8	active	active	ADJ
dti-2103	95	9	site	site	NOUN
dti-2103	95	10	in	in	ADP
dti-2103	95	11	response	response	NOUN
dti-2103	95	12	to	to	ADP
dti-2103	95	13	binding	bind	VERB
dti-2103	95	14	of	of	ADP
dti-2103	95	15	its	its	PRON
dti-2103	95	16	natural	natural	ADJ
dti-2103	95	17	substrate	substrate	NOUN
dti-2103	95	18	were	be	AUX
dti-2103	95	19	analyzed	analyze	VERB
dti-2103	95	20	.	.	PUNCT
dti-2103	96	1	using	use	VERB
dti-2103	96	2	information	information	NOUN
dti-2103	96	3	of	of	ADP
dti-2103	96	4	the	the	DET
dti-2103	96	5	active	active	ADJ
dti-2103	96	6	site	site	NOUN
dti-2103	96	7	pocket	pocket	NOUN
dti-2103	96	8	of	of	ADP
dti-2103	96	9	ugpase	ugpase	NOUN
dti-2103	96	10	and	and	CCONJ
dti-2103	96	11	literature	literature	NOUN
dti-2103	96	12	-	-	PUNCT
dti-2103	96	13	based	base	VERB
dti-2103	96	14	evidence	evidence	NOUN
dti-2103	96	15	(	(	PUNCT
dti-2103	96	16	11,14,17,21	11,14,17,21	NUM
dti-2103	96	17	-	-	SYM
dti-2103	96	18	23	23	NUM
dti-2103	96	19	)	)	PUNCT
dti-2103	96	20	,	,	PUNCT
dti-2103	96	21	udp	udp	NOUN
dti-2103	96	22	was	be	AUX
dti-2103	96	23	selected	select	VERB
dti-2103	96	24	as	as	ADP
dti-2103	96	25	a	a	DET
dti-2103	96	26	probable	probable	ADJ
dti-2103	96	27	inhibitor	inhibitor	NOUN
dti-2103	96	28	of	of	ADP
dti-2103	96	29	s.	s.	PROPN
dti-2103	96	30	pneumoniae	pneumoniae	ADJ
dti-2103	96	31	ugpase	ugpase	NOUN
dti-2103	96	32	.	.	PUNCT
dti-2103	97	1	in	in	ADP
dti-2103	97	2	silico	silico	NOUN
dti-2103	97	3	analysis	analysis	NOUN
dti-2103	97	4	showed	show	VERB
dti-2103	97	5	that	that	SCONJ
dti-2103	97	6	udp	udp	NOUN
dti-2103	97	7	binding	binding	NOUN
dti-2103	97	8	did	do	AUX
dti-2103	97	9	not	not	PART
dti-2103	97	10	result	result	VERB
dti-2103	97	11	in	in	ADP
dti-2103	97	12	alteration	alteration	NOUN
dti-2103	97	13	in	in	ADP
dti-2103	97	14	local	local	ADJ
dti-2103	97	15	conformation	conformation	NOUN
dti-2103	97	16	of	of	ADP
dti-2103	97	17	enzymatic	enzymatic	ADJ
dti-2103	97	18	active	active	ADJ
dti-2103	97	19	site	site	NOUN
dti-2103	97	20	.	.	PUNCT
dti-2103	98	1	the	the	DET
dti-2103	98	2	effective	effective	ADJ
dti-2103	98	3	inhibitory	inhibitory	ADJ
dti-2103	98	4	concentrations	concentration	NOUN
dti-2103	98	5	of	of	ADP
dti-2103	98	6	udp	udp	NOUN
dti-2103	98	7	,	,	PUNCT
dti-2103	98	8	its	its	PRON
dti-2103	98	9	extent	extent	NOUN
dti-2103	98	10	of	of	ADP
dti-2103	98	11	inhibition	inhibition	NOUN
dti-2103	98	12	,	,	PUNCT
dti-2103	98	13	and	and	CCONJ
dti-2103	98	14	probable	probable	ADJ
dti-2103	98	15	toxicity	toxicity	NOUN
dti-2103	98	16	to	to	ADP
dti-2103	98	17	host	host	NOUN
dti-2103	98	18	cell	cell	NOUN
dti-2103	98	19	lines	line	NOUN
dti-2103	98	20	were	be	AUX
dti-2103	98	21	studied	study	VERB
dti-2103	98	22	.	.	PUNCT
dti-2103	99	1	the	the	DET
dti-2103	99	2	pneumococcal	pneumococcal	ADJ
dti-2103	99	3	virulence	virulence	NOUN
dti-2103	99	4	and	and	CCONJ
dti-2103	99	5	clearance	clearance	NOUN
dti-2103	99	6	of	of	ADP
dti-2103	99	7	infection	infection	NOUN
dti-2103	99	8	in	in	ADP
dti-2103	99	9	response	response	NOUN
dti-2103	99	10	to	to	ADP
dti-2103	99	11	udp	udp	NOUN
dti-2103	99	12	were	be	AUX
dti-2103	99	13	explored	explore	VERB
dti-2103	99	14	in	in	ADP
dti-2103	99	15	vitro	vitro	X
dti-2103	99	16	.	.	PUNCT
dti-2103	100	1	effect	effect	NOUN
dti-2103	100	2	of	of	ADP
dti-2103	100	3	udp	udp	NOUN
dti-2103	100	4	on	on	ADP
dti-2103	100	5	ugpase	ugpase	NOUN
dti-2103	100	6	activity	activity	NOUN
dti-2103	100	7	ugpase	ugpase	NOUN
dti-2103	100	8	activity	activity	NOUN
dti-2103	100	9	was	be	AUX
dti-2103	100	10	evaluated	evaluate	VERB
dti-2103	100	11	at	at	ADP
dti-2103	100	12	different	different	ADJ
dti-2103	100	13	udp	udp	NOUN
dti-2103	100	14	concentrations	concentration	NOUN
dti-2103	100	15	(	(	PUNCT
dti-2103	100	16	0.05	0.05	NUM
dti-2103	100	17	-	-	SYM
dti-2103	100	18	100	100	NUM
dti-2103	100	19	μm	μm	NUM
dti-2103	100	20	)	)	PUNCT
dti-2103	100	21	in	in	ADP
dti-2103	100	22	a549	a549	PROPN
dti-2103	100	23	cells	cell	NOUN
dti-2103	100	24	and	and	CCONJ
dti-2103	100	25	s.	s.	PROPN
dti-2103	100	26	pneumoniae	pneumoniae	ADJ
dti-2103	100	27	d39	d39	NOUN
dti-2103	100	28	strain	strain	NOUN
dti-2103	100	29	.	.	PUNCT
dti-2103	101	1	concentration	concentration	NOUN
dti-2103	101	2	-	-	PUNCT
dti-2103	101	3	dependent	dependent	ADJ
dti-2103	101	4	dose	dose	NOUN
dti-2103	101	5	response	response	NOUN
dti-2103	101	6	curve	curve	NOUN
dti-2103	101	7	showed	show	VERB
dti-2103	101	8	that	that	SCONJ
dti-2103	101	9	udp	udp	NOUN
dti-2103	101	10	decreased	decrease	VERB
dti-2103	101	11	ugpase	ugpase	NOUN
dti-2103	101	12	activity	activity	NOUN
dti-2103	101	13	in	in	ADP
dti-2103	101	14	host	host	NOUN
dti-2103	101	15	a549	a549	PROPN
dti-2103	101	16	cells	cell	NOUN
dti-2103	101	17	(	(	PUNCT
dti-2103	101	18	fig	fig	NOUN
dti-2103	101	19	.	.	PUNCT
dti-2103	102	1	1a	1a	NOUN
dti-2103	102	2	)	)	PUNCT
dti-2103	102	3	as	as	ADV
dti-2103	102	4	well	well	ADV
dti-2103	102	5	as	as	ADP
dti-2103	102	6	in	in	ADP
dti-2103	102	7	pneumococcus	pneumococcus	NOUN
dti-2103	102	8	(	(	PUNCT
dti-2103	102	9	fig	fig	NOUN
dti-2103	102	10	.	.	PUNCT
dti-2103	103	1	1b	1b	NUM
dti-2103	103	2	)	)	PUNCT
dti-2103	103	3	.	.	PUNCT
dti-2103	104	1	udptreated	udptreate	VERB
dti-2103	104	2	a549	a549	PROPN
dti-2103	104	3	cells	cell	NOUN
dti-2103	104	4	showed	show	VERB
dti-2103	104	5	a	a	DET
dti-2103	104	6	declined	decline	VERB
dti-2103	104	7	ugpase	ugpase	NOUN
dti-2103	104	8	activity	activity	NOUN
dti-2103	104	9	in	in	ADP
dti-2103	104	10	comparison	comparison	NOUN
dti-2103	104	11	to	to	ADP
dti-2103	104	12	untreated	untreated	ADJ
dti-2103	104	13	(	(	PUNCT
dti-2103	104	14	0.0	0.0	NUM
dti-2103	104	15	μm	μm	NOUN
dti-2103	104	16	)	)	PUNCT
dti-2103	104	17	control	control	NOUN
dti-2103	104	18	cells	cell	NOUN
dti-2103	104	19	(	(	PUNCT
dti-2103	104	20	fig	fig	NOUN
dti-2103	104	21	.	.	PUNCT
dti-2103	105	1	1a	1a	NOUN
dti-2103	105	2	)	)	PUNCT
dti-2103	105	3	.	.	PUNCT
dti-2103	106	1	ugpase	ugpase	NOUN
dti-2103	106	2	activity	activity	NOUN
dti-2103	106	3	was	be	AUX
dti-2103	106	4	not	not	PART
dti-2103	106	5	significantly	significantly	ADV
dti-2103	106	6	decreased	decrease	VERB
dti-2103	106	7	in	in	ADP
dti-2103	106	8	the	the	DET
dti-2103	106	9	cells	cell	NOUN
dti-2103	106	10	treated	treat	VERB
dti-2103	106	11	with	with	ADP
dti-2103	106	12	0.1	0.1	NUM
dti-2103	106	13	-	-	SYM
dti-2103	106	14	3	3	NUM
dti-2103	106	15	μm	μm	NOUN
dti-2103	106	16	udp	udp	NOUN
dti-2103	106	17	.	.	PUNCT
dti-2103	107	1	however	however	ADV
dti-2103	107	2	,	,	PUNCT
dti-2103	107	3	activity	activity	NOUN
dti-2103	107	4	was	be	AUX
dti-2103	107	5	significantly	significantly	ADV
dti-2103	107	6	decreased	decrease	VERB
dti-2103	107	7	at	at	ADP
dti-2103	107	8	5	5	NUM
dti-2103	107	9	μm	μm	NOUN
dti-2103	107	10	(	(	PUNCT
dti-2103	107	11	p	p	X
dti-2103	107	12	=	=	NOUN
dti-2103	107	13	0.009	0.009	NUM
dti-2103	107	14	)	)	PUNCT
dti-2103	107	15	and	and	CCONJ
dti-2103	107	16	100	100	NUM
dti-2103	107	17	μm	μm	NOUN
dti-2103	107	18	(	(	PUNCT
dti-2103	107	19	p	p	X
dti-2103	107	20	=	=	NOUN
dti-2103	107	21	0.011	0.011	NUM
dti-2103	107	22	)	)	PUNCT
dti-2103	107	23	udp	udp	NOUN
dti-2103	107	24	treatments	treatment	NOUN
dti-2103	107	25	.	.	PUNCT
dti-2103	108	1	the	the	DET
dti-2103	108	2	inhibition	inhibition	NOUN
dti-2103	108	3	of	of	ADP
dti-2103	108	4	ugpase	ugpase	NOUN
dti-2103	108	5	activity	activity	NOUN
dti-2103	108	6	in	in	ADP
dti-2103	108	7	a549	a549	PROPN
dti-2103	108	8	cells	cell	NOUN
dti-2103	108	9	was	be	AUX
dti-2103	108	10	2.8	2.8	NUM
dti-2103	108	11	fold	fold	ADV
dti-2103	108	12	higher	higher	ADV
dti-2103	108	13	at	at	ADP
dti-2103	108	14	100	100	NUM
dti-2103	108	15	μm	μm	NOUN
dti-2103	108	16	udp	udp	NOUN
dti-2103	108	17	treatment	treatment	NOUN
dti-2103	108	18	in	in	ADP
dti-2103	108	19	comparison	comparison	NOUN
dti-2103	108	20	to	to	ADP
dti-2103	108	21	5	5	NUM
dti-2103	108	22	μm	μm	NUM
dti-2103	108	23	treatment	treatment	NOUN
dti-2103	108	24	.	.	PUNCT
dti-2103	109	1	in	in	ADP
dti-2103	109	2	s.	s.	PROPN
dti-2103	109	3	pneumoniae	pneumoniae	ADJ
dti-2103	109	4	d39	d39	NOUN
dti-2103	109	5	strain	strain	NOUN
dti-2103	109	6	,	,	PUNCT
dti-2103	109	7	a	a	DET
dti-2103	109	8	significant	significant	ADJ
dti-2103	109	9	decrease	decrease	NOUN
dti-2103	109	10	in	in	ADP
dti-2103	109	11	ugpase	ugpase	NOUN
dti-2103	109	12	activity	activity	NOUN
dti-2103	109	13	was	be	AUX
dti-2103	109	14	observed	observe	VERB
dti-2103	109	15	at	at	ADP
dti-2103	109	16	2	2	NUM
dti-2103	109	17	μm	μm	NOUN
dti-2103	109	18	udp	udp	NOUN
dti-2103	109	19	(	(	PUNCT
dti-2103	109	20	p	p	NOUN
dti-2103	109	21	=	=	NOUN
dti-2103	109	22	0.02	0.02	NUM
dti-2103	109	23	)	)	PUNCT
dti-2103	109	24	treatment	treatment	NOUN
dti-2103	109	25	(	(	PUNCT
dti-2103	109	26	fig	fig	NOUN
dti-2103	109	27	.	.	PUNCT
dti-2103	109	28	1b	1b	NUM
dti-2103	109	29	)	)	PUNCT
dti-2103	109	30	.	.	PUNCT
dti-2103	110	1	at	at	ADP
dti-2103	110	2	5	5	NUM
dti-2103	110	3	μm	μm	NOUN
dti-2103	110	4	udp	udp	NOUN
dti-2103	110	5	,	,	PUNCT
dti-2103	110	6	threefold	threefold	ADJ
dti-2103	110	7	inhibition	inhibition	NOUN
dti-2103	110	8	(	(	PUNCT
dti-2103	110	9	p	p	X
dti-2103	110	10	=	=	NOUN
dti-2103	110	11	0.01	0.01	NUM
dti-2103	110	12	)	)	PUNCT
dti-2103	110	13	was	be	AUX
dti-2103	110	14	observed	observe	VERB
dti-2103	110	15	in	in	ADP
dti-2103	110	16	ugpase	ugpase	NOUN
dti-2103	110	17	activity	activity	NOUN
dti-2103	110	18	in	in	ADP
dti-2103	110	19	comparison	comparison	NOUN
dti-2103	110	20	to	to	ADP
dti-2103	110	21	100	100	NUM
dti-2103	110	22	μm	μm	NUM
dti-2103	110	23	.	.	PUNCT
dti-2103	111	1	further	far	ADV
dti-2103	111	2	,	,	PUNCT
dti-2103	111	3	effect	effect	NOUN
dti-2103	111	4	of	of	ADP
dti-2103	111	5	udp	udp	NOUN
dti-2103	111	6	(	(	PUNCT
dti-2103	111	7	at	at	ADP
dti-2103	111	8	5	5	NUM
dti-2103	111	9	and	and	CCONJ
dti-2103	111	10	100	100	NUM
dti-2103	111	11	μm	μm	NUM
dti-2103	111	12	)	)	PUNCT
dti-2103	111	13	on	on	ADP
dti-2103	111	14	ugpase	ugpase	NOUN
dti-2103	111	15	activity	activity	NOUN
dti-2103	111	16	was	be	AUX
dti-2103	111	17	evaluated	evaluate	VERB
dti-2103	111	18	in	in	ADP
dti-2103	111	19	invasive	invasive	ADJ
dti-2103	111	20	s.	s.	PROPN
dti-2103	111	21	pneumoniae	pneumoniae	PROPN
dti-2103	111	22	isolate	isolate	PROPN
dti-2103	111	23	(	(	PUNCT
dti-2103	111	24	retrieved	retrieve	VERB
dti-2103	111	25	from	from	ADP
dti-2103	111	26	blood	blood	NOUN
dti-2103	111	27	sample	sample	NOUN
dti-2103	111	28	)	)	PUNCT
dti-2103	111	29	,	,	PUNCT
dti-2103	111	30	which	which	PRON
dti-2103	111	31	showed	show	VERB
dti-2103	111	32	a	a	DET
dti-2103	111	33	decrease	decrease	NOUN
dti-2103	111	34	in	in	ADP
dti-2103	111	35	activity	activity	NOUN
dti-2103	111	36	at	at	ADP
dti-2103	111	37	5	5	NUM
dti-2103	111	38	μm	μm	NOUN
dti-2103	111	39	udp	udp	NOUN
dti-2103	111	40	(	(	PUNCT
dti-2103	111	41	p	p	NOUN
dti-2103	111	42	=	=	NOUN
dti-2103	111	43	0.015	0.015	NUM
dti-2103	111	44	)	)	PUNCT
dti-2103	111	45	(	(	PUNCT
dti-2103	111	46	fig	fig	NOUN
dti-2103	111	47	.	.	PUNCT
dti-2103	112	1	1c	1c	NOUN
dti-2103	112	2	)	)	PUNCT
dti-2103	112	3	.	.	PUNCT
dti-2103	113	1	comparative	comparative	ADJ
dti-2103	113	2	analysis	analysis	NOUN
dti-2103	113	3	of	of	ADP
dti-2103	113	4	udp	udp	NOUN
dti-2103	113	5	treatment	treatment	NOUN
dti-2103	113	6	on	on	ADP
dti-2103	113	7	blood	blood	NOUN
dti-2103	113	8	isolate	isolate	NOUN
dti-2103	113	9	and	and	CCONJ
dti-2103	113	10	reference	reference	NOUN
dti-2103	113	11	d39	d39	NOUN
dti-2103	113	12	strain	strain	NOUN
dti-2103	113	13	showed	show	VERB
dti-2103	113	14	that	that	SCONJ
dti-2103	113	15	5	5	NUM
dti-2103	113	16	μm	μm	NOUN
dti-2103	113	17	udp	udp	NOUN
dti-2103	113	18	treatments	treatment	NOUN
dti-2103	113	19	for	for	ADP
dti-2103	113	20	1	1	NUM
dti-2103	113	21	hour	hour	NOUN
dti-2103	113	22	were	be	AUX
dti-2103	113	23	effective	effective	ADJ
dti-2103	113	24	to	to	PART
dti-2103	113	25	reduce	reduce	VERB
dti-2103	113	26	the	the	DET
dti-2103	113	27	bacterial	bacterial	ADJ
dti-2103	113	28	ugpase	ugpase	NOUN
dti-2103	113	29	activity	activity	NOUN
dti-2103	113	30	(	(	PUNCT
dti-2103	113	31	fig	fig	NOUN
dti-2103	113	32	.	.	PUNCT
dti-2103	114	1	1c	1c	NOUN
dti-2103	114	2	)	)	PUNCT
dti-2103	114	3	by	by	ADP
dti-2103	114	4	half	half	NOUN
dti-2103	114	5	than	than	ADP
dti-2103	114	6	in	in	ADP
dti-2103	114	7	its	its	PRON
dti-2103	114	8	host	host	NOUN
dti-2103	114	9	counterpart	counterpart	NOUN
dti-2103	114	10	(	(	PUNCT
dti-2103	114	11	fig	fig	NOUN
dti-2103	114	12	.	.	PUNCT
dti-2103	115	1	1a	1a	NOUN
dti-2103	115	2	)	)	PUNCT
dti-2103	115	3	.	.	PUNCT
dti-2103	116	1	sharma	sharma	PROPN
dti-2103	116	2	et	et	PROPN
dti-2103	116	3	al	al	PROPN
dti-2103	116	4	29	29	NUM
dti-2103	116	5	©	©	PROPN
dti-2103	116	6	2020	2020	NUM
dti-2103	116	7	the	the	DET
dti-2103	116	8	authors	author	NOUN
dti-2103	116	9	.	.	PUNCT
dti-2103	117	1	published	publish	VERB
dti-2103	117	2	by	by	ADP
dti-2103	117	3	aboutscience	aboutscience	NOUN
dti-2103	117	4	further	further	ADJ
dti-2103	117	5	analysis	analysis	NOUN
dti-2103	117	6	of	of	ADP
dti-2103	117	7	ugpase	ugpase	NOUN
dti-2103	117	8	expression	expression	NOUN
dti-2103	117	9	in	in	ADP
dti-2103	117	10	a549	a549	PROPN
dti-2103	117	11	cell	cell	NOUN
dti-2103	117	12	lysate	lysate	NOUN
dti-2103	117	13	using	use	VERB
dti-2103	117	14	human	human	ADJ
dti-2103	117	15	anti	anti	ADJ
dti-2103	117	16	-	-	ADJ
dti-2103	117	17	ugp2	ugp2	ADJ
dti-2103	117	18	antibody	antibody	NOUN
dti-2103	117	19	reconfirmed	reconfirm	VERB
dti-2103	117	20	the	the	DET
dti-2103	117	21	significant	significant	ADJ
dti-2103	117	22	decrease	decrease	NOUN
dti-2103	117	23	(	(	PUNCT
dti-2103	117	24	p	p	X
dti-2103	117	25	=	=	NOUN
dti-2103	117	26	0.03	0.03	NUM
dti-2103	117	27	)	)	PUNCT
dti-2103	117	28	at	at	ADP
dti-2103	117	29	100	100	NUM
dti-2103	117	30	μm	μm	NOUN
dti-2103	117	31	udp	udp	NOUN
dti-2103	117	32	treatment	treatment	NOUN
dti-2103	117	33	in	in	ADP
dti-2103	117	34	comparison	comparison	NOUN
dti-2103	117	35	to	to	ADP
dti-2103	117	36	5	5	NUM
dti-2103	117	37	μm	μm	NUM
dti-2103	117	38	treated	treat	VERB
dti-2103	117	39	and	and	CCONJ
dti-2103	117	40	control	control	NOUN
dti-2103	117	41	(	(	PUNCT
dti-2103	117	42	untreated	untreated	ADJ
dti-2103	117	43	)	)	PUNCT
dti-2103	117	44	cells	cell	NOUN
dti-2103	117	45	(	(	PUNCT
dti-2103	117	46	fig	fig	NOUN
dti-2103	117	47	.	.	PUNCT
dti-2103	118	1	1d	1d	NUM
dti-2103	118	2	)	)	PUNCT
dti-2103	118	3	.	.	PUNCT
dti-2103	119	1	however	however	ADV
dti-2103	119	2	,	,	PUNCT
dti-2103	119	3	we	we	PRON
dti-2103	119	4	could	could	AUX
dti-2103	119	5	not	not	PART
dti-2103	119	6	analyze	analyze	VERB
dti-2103	119	7	the	the	DET
dti-2103	119	8	ugpase	ugpase	NOUN
dti-2103	119	9	expression	expression	NOUN
dti-2103	119	10	in	in	ADP
dti-2103	119	11	s.	s.	PROPN
dti-2103	119	12	pneumoniae	pneumoniae	ADJ
dti-2103	119	13	due	due	ADP
dti-2103	119	14	to	to	ADP
dti-2103	119	15	unavailability	unavailability	NOUN
dti-2103	119	16	of	of	ADP
dti-2103	119	17	antibody	antibody	NOUN
dti-2103	119	18	against	against	ADP
dti-2103	119	19	bacterial	bacterial	ADJ
dti-2103	119	20	enzymes	enzyme	NOUN
dti-2103	119	21	.	.	PUNCT
dti-2103	120	1	udp	udp	NOUN
dti-2103	120	2	treatment	treatment	NOUN
dti-2103	120	3	and	and	CCONJ
dti-2103	120	4	a549	a549	PROPN
dti-2103	120	5	cell	cell	NOUN
dti-2103	120	6	survival	survival	NOUN
dti-2103	120	7	the	the	DET
dti-2103	120	8	effect	effect	NOUN
dti-2103	120	9	of	of	ADP
dti-2103	120	10	udp	udp	NOUN
dti-2103	120	11	on	on	ADP
dti-2103	120	12	a549	a549	PROPN
dti-2103	120	13	cell	cell	NOUN
dti-2103	120	14	viability	viability	NOUN
dti-2103	120	15	was	be	AUX
dti-2103	120	16	evaluated	evaluate	VERB
dti-2103	120	17	in	in	ADP
dti-2103	120	18	a	a	DET
dti-2103	120	19	dose	dose	NOUN
dti-2103	120	20	-	-	PUNCT
dti-2103	120	21	dependent	dependent	ADJ
dti-2103	120	22	manner	manner	NOUN
dti-2103	120	23	in	in	ADP
dti-2103	120	24	the	the	DET
dti-2103	120	25	absence	absence	NOUN
dti-2103	120	26	(	(	PUNCT
dti-2103	120	27	control	control	NOUN
dti-2103	120	28	)	)	PUNCT
dti-2103	120	29	and	and	CCONJ
dti-2103	120	30	presence	presence	NOUN
dti-2103	120	31	of	of	ADP
dti-2103	120	32	s.	s.	PROPN
dti-2103	120	33	pneumoniae	pneumoniae	ADJ
dti-2103	120	34	infection	infection	NOUN
dti-2103	120	35	(	(	PUNCT
dti-2103	120	36	fig	fig	NOUN
dti-2103	120	37	.	.	PUNCT
dti-2103	121	1	2	2	NUM
dti-2103	121	2	)	)	PUNCT
dti-2103	121	3	.	.	PUNCT
dti-2103	122	1	uninfected	uninfected	ADJ
dti-2103	122	2	(	(	PUNCT
dti-2103	122	3	control	control	NOUN
dti-2103	122	4	)	)	PUNCT
dti-2103	122	5	cells	cell	NOUN
dti-2103	122	6	treated	treat	VERB
dti-2103	122	7	with	with	ADP
dti-2103	122	8	udp	udp	NOUN
dti-2103	122	9	(	(	PUNCT
dti-2103	122	10	0.5	0.5	NUM
dti-2103	122	11	-	-	SYM
dti-2103	122	12	100	100	NUM
dti-2103	122	13	μm	μm	NUM
dti-2103	122	14	)	)	PUNCT
dti-2103	122	15	showed	show	VERB
dti-2103	122	16	negligible	negligible	ADJ
dti-2103	122	17	changes	change	NOUN
dti-2103	122	18	in	in	ADP
dti-2103	122	19	the	the	DET
dti-2103	122	20	percentage	percentage	NOUN
dti-2103	122	21	cell	cell	NOUN
dti-2103	122	22	viability	viability	NOUN
dti-2103	122	23	.	.	PUNCT
dti-2103	123	1	however	however	ADV
dti-2103	123	2	,	,	PUNCT
dti-2103	123	3	a549	a549	PROPN
dti-2103	123	4	cells	cell	NOUN
dti-2103	123	5	infected	infect	VERB
dti-2103	123	6	with	with	ADP
dti-2103	123	7	pneumococci	pneumococci	NOUN
dti-2103	123	8	(	(	PUNCT
dti-2103	123	9	d39	d39	NOUN
dti-2103	123	10	and	and	CCONJ
dti-2103	123	11	blood	blood	NOUN
dti-2103	123	12	isolate	isolate	NOUN
dti-2103	123	13	)	)	PUNCT
dti-2103	123	14	showed	show	VERB
dti-2103	123	15	a	a	DET
dti-2103	123	16	significant	significant	ADJ
dti-2103	123	17	decrease	decrease	NOUN
dti-2103	123	18	in	in	ADP
dti-2103	123	19	percent	percent	NOUN
dti-2103	123	20	viability	viability	NOUN
dti-2103	123	21	in	in	ADP
dti-2103	123	22	the	the	DET
dti-2103	123	23	absence	absence	NOUN
dti-2103	123	24	of	of	ADP
dti-2103	123	25	udp	udp	NOUN
dti-2103	123	26	treatment	treatment	NOUN
dti-2103	123	27	(	(	PUNCT
dti-2103	123	28	p	p	NOUN
dti-2103	123	29	=	=	NOUN
dti-2103	123	30	0.001	0.001	NUM
dti-2103	123	31	)	)	PUNCT
dti-2103	123	32	.	.	PUNCT
dti-2103	124	1	notably	notably	ADV
dti-2103	124	2	,	,	PUNCT
dti-2103	124	3	the	the	DET
dti-2103	124	4	viability	viability	NOUN
dti-2103	124	5	of	of	ADP
dti-2103	124	6	infected	infected	ADJ
dti-2103	124	7	a549	a549	PROPN
dti-2103	124	8	cells	cell	NOUN
dti-2103	124	9	was	be	AUX
dti-2103	124	10	elevated	elevate	VERB
dti-2103	124	11	at	at	ADP
dti-2103	124	12	higher	high	ADJ
dti-2103	124	13	udp	udp	NOUN
dti-2103	124	14	treatments	treatment	NOUN
dti-2103	124	15	(	(	PUNCT
dti-2103	124	16	>	>	SYM
dti-2103	124	17	10	10	NUM
dti-2103	124	18	μm	μm	NUM
dti-2103	124	19	)	)	PUNCT
dti-2103	124	20	in	in	ADP
dti-2103	124	21	a	a	DET
dti-2103	124	22	dose	dose	NOUN
dti-2103	124	23	-	-	PUNCT
dti-2103	124	24	dependent	dependent	ADJ
dti-2103	124	25	manner	manner	NOUN
dti-2103	124	26	(	(	PUNCT
dti-2103	124	27	fig	fig	NOUN
dti-2103	124	28	.	.	PUNCT
dti-2103	125	1	2a	2a	NUM
dti-2103	125	2	)	)	PUNCT
dti-2103	125	3	.	.	PUNCT
dti-2103	126	1	further	far	ADV
dti-2103	126	2	,	,	PUNCT
dti-2103	126	3	a	a	DET
dti-2103	126	4	comparative	comparative	ADJ
dti-2103	126	5	analysis	analysis	NOUN
dti-2103	126	6	of	of	ADP
dti-2103	126	7	udp	udp	NOUN
dti-2103	126	8	treatments	treatment	NOUN
dti-2103	126	9	(	(	PUNCT
dti-2103	126	10	0	0	NUM
dti-2103	126	11	,	,	PUNCT
dti-2103	126	12	5	5	NUM
dti-2103	126	13	,	,	PUNCT
dti-2103	126	14	100	100	NUM
dti-2103	126	15	μm	μm	NUM
dti-2103	126	16	)	)	PUNCT
dti-2103	126	17	to	to	ADP
dti-2103	126	18	a549	a549	PROPN
dti-2103	126	19	cells	cell	NOUN
dti-2103	126	20	showed	show	VERB
dti-2103	126	21	significantly	significantly	ADV
dti-2103	126	22	improved	improve	VERB
dti-2103	126	23	viability	viability	NOUN
dti-2103	126	24	at	at	ADP
dti-2103	126	25	100	100	NUM
dti-2103	126	26	μm	μm	NUM
dti-2103	126	27	treatment	treatment	NOUN
dti-2103	126	28	in	in	ADP
dti-2103	126	29	d39	d39	NOUN
dti-2103	126	30	(	(	PUNCT
dti-2103	126	31	p	p	NOUN
dti-2103	126	32	=	=	NOUN
dti-2103	126	33	0.009	0.009	NUM
dti-2103	126	34	)	)	PUNCT
dti-2103	126	35	and	and	CCONJ
dti-2103	126	36	blood	blood	NOUN
dti-2103	126	37	isolate	isolate	NOUN
dti-2103	126	38	(	(	PUNCT
dti-2103	126	39	p	p	X
dti-2103	126	40	=	=	NOUN
dti-2103	126	41	0.04	0.04	NUM
dti-2103	126	42	)	)	PUNCT
dti-2103	126	43	infected	infected	ADJ
dti-2103	126	44	cells	cell	NOUN
dti-2103	126	45	,	,	PUNCT
dti-2103	126	46	while	while	SCONJ
dti-2103	126	47	no	no	DET
dti-2103	126	48	change	change	NOUN
dti-2103	126	49	in	in	ADP
dti-2103	126	50	cell	cell	NOUN
dti-2103	126	51	viability	viability	NOUN
dti-2103	126	52	was	be	AUX
dti-2103	126	53	observed	observe	VERB
dti-2103	126	54	in	in	ADP
dti-2103	126	55	uninfected	uninfected	ADJ
dti-2103	126	56	(	(	PUNCT
dti-2103	126	57	control	control	NOUN
dti-2103	126	58	)	)	PUNCT
dti-2103	126	59	cells	cell	NOUN
dti-2103	126	60	(	(	PUNCT
dti-2103	126	61	fig	fig	NOUN
dti-2103	126	62	.	.	PUNCT
dti-2103	126	63	2b	2b	NUM
dti-2103	126	64	)	)	PUNCT
dti-2103	126	65	.	.	PUNCT
dti-2103	127	1	thus	thus	ADV
dti-2103	127	2	,	,	PUNCT
dti-2103	127	3	udp	udp	NOUN
dti-2103	127	4	seems	seem	VERB
dti-2103	127	5	safer	safe	ADJ
dti-2103	127	6	to	to	PART
dti-2103	127	7	explore	explore	VERB
dti-2103	127	8	for	for	ADP
dti-2103	127	9	its	its	PRON
dti-2103	127	10	potential	potential	NOUN
dti-2103	127	11	as	as	SCONJ
dti-2103	127	12	it	it	PRON
dti-2103	127	13	did	do	AUX
dti-2103	127	14	not	not	PART
dti-2103	127	15	exert	exert	VERB
dti-2103	127	16	any	any	DET
dti-2103	127	17	cytotoxic	cytotoxic	ADJ
dti-2103	127	18	effect	effect	NOUN
dti-2103	127	19	on	on	ADP
dti-2103	127	20	a549	a549	PROPN
dti-2103	127	21	cells	cell	NOUN
dti-2103	127	22	(	(	PUNCT
dti-2103	127	23	fig	fig	NOUN
dti-2103	127	24	.	.	PUNCT
dti-2103	128	1	2	2	NUM
dti-2103	128	2	)	)	PUNCT
dti-2103	128	3	,	,	PUNCT
dti-2103	128	4	while	while	SCONJ
dti-2103	128	5	it	it	PRON
dti-2103	128	6	improved	improve	VERB
dti-2103	128	7	the	the	DET
dti-2103	128	8	percentage	percentage	NOUN
dti-2103	128	9	cell	cell	NOUN
dti-2103	128	10	viability	viability	NOUN
dti-2103	128	11	in	in	ADP
dti-2103	128	12	the	the	DET
dti-2103	128	13	presence	presence	NOUN
dti-2103	128	14	of	of	ADP
dti-2103	128	15	bacterial	bacterial	ADJ
dti-2103	128	16	infection	infection	NOUN
dti-2103	128	17	.	.	PUNCT
dti-2103	129	1	further	far	ADV
dti-2103	129	2	,	,	PUNCT
dti-2103	129	3	effect	effect	NOUN
dti-2103	129	4	of	of	ADP
dti-2103	129	5	ugpase	ugpase	NOUN
dti-2103	129	6	inhibition	inhibition	NOUN
dti-2103	129	7	on	on	ADP
dti-2103	129	8	adherence	adherence	NOUN
dti-2103	129	9	and	and	CCONJ
dti-2103	129	10	phagocytosis	phagocytosis	NOUN
dti-2103	129	11	of	of	ADP
dti-2103	129	12	s.	s.	PROPN
dti-2103	129	13	pneumoniae	pneumoniae	PROPN
dti-2103	129	14	(	(	PUNCT
dti-2103	129	15	blood	blood	NOUN
dti-2103	129	16	isolate	isolate	NOUN
dti-2103	129	17	and	and	CCONJ
dti-2103	129	18	standard	standard	ADJ
dti-2103	129	19	strains	strain	NOUN
dti-2103	129	20	mtcc	mtcc	ADJ
dti-2103	129	21	655	655	NUM
dti-2103	129	22	;	;	PUNCT
dti-2103	129	23	a	a	DET
dti-2103	129	24	highly	highly	ADV
dti-2103	129	25	capsular	capsular	ADJ
dti-2103	129	26	strain	strain	NOUN
dti-2103	129	27	and	and	CCONJ
dti-2103	129	28	d39	d39	NOUN
dti-2103	129	29	)	)	PUNCT
dti-2103	129	30	was	be	AUX
dti-2103	129	31	evaluated	evaluate	VERB
dti-2103	129	32	at	at	ADP
dti-2103	129	33	effective	effective	ADJ
dti-2103	129	34	5	5	NUM
dti-2103	129	35	μm	μm	NOUN
dti-2103	129	36	udp	udp	NOUN
dti-2103	129	37	concentration	concentration	NOUN
dti-2103	129	38	(	(	PUNCT
dti-2103	129	39	fig	fig	NOUN
dti-2103	129	40	.	.	NOUN
dti-2103	129	41	1	1	NUM
dti-2103	129	42	)	)	PUNCT
dti-2103	129	43	.	.	PUNCT
dti-2103	130	1	fig	fig	NOUN
dti-2103	130	2	.	.	PUNCT
dti-2103	131	1	1	1	NUM
dti-2103	131	2	uridine	uridine	NOUN
dti-2103	131	3	diphosphate	diphosphate	NOUN
dti-2103	131	4	(	(	PUNCT
dti-2103	131	5	udp)-glucose	udp)-glucose	PROPN
dti-2103	131	6	pyrophosphorylase	pyrophosphorylase	NOUN
dti-2103	131	7	(	(	PUNCT
dti-2103	131	8	ugpase	ugpase	NOUN
dti-2103	131	9	)	)	PUNCT
dti-2103	131	10	activity	activity	NOUN
dti-2103	131	11	in	in	ADP
dti-2103	131	12	response	response	NOUN
dti-2103	131	13	to	to	ADP
dti-2103	131	14	fractional	fractional	ADJ
dti-2103	131	15	treatment	treatment	NOUN
dti-2103	131	16	of	of	ADP
dti-2103	131	17	udp	udp	NOUN
dti-2103	131	18	in	in	ADP
dti-2103	131	19	(	(	PUNCT
dti-2103	131	20	a	a	NOUN
dti-2103	131	21	)	)	PUNCT
dti-2103	131	22	a549	a549	PROPN
dti-2103	131	23	cells	cell	NOUN
dti-2103	131	24	,	,	PUNCT
dti-2103	131	25	(	(	PUNCT
dti-2103	131	26	b	b	X
dti-2103	131	27	)	)	PUNCT
dti-2103	131	28	s.	s.	PROPN
dti-2103	131	29	pneumoniae	pneumoniae	ADJ
dti-2103	131	30	d39	d39	NOUN
dti-2103	131	31	strain	strain	NOUN
dti-2103	131	32	,	,	PUNCT
dti-2103	131	33	(	(	PUNCT
dti-2103	131	34	c	c	X
dti-2103	131	35	)	)	PUNCT
dti-2103	131	36	comparative	comparative	ADJ
dti-2103	131	37	analysis	analysis	NOUN
dti-2103	131	38	of	of	ADP
dti-2103	131	39	s.	s.	PROPN
dti-2103	131	40	pneumoniae	pneumoniae	ADJ
dti-2103	131	41	ugpase	ugpase	NOUN
dti-2103	131	42	activity	activity	NOUN
dti-2103	131	43	in	in	ADP
dti-2103	131	44	response	response	NOUN
dti-2103	131	45	to	to	ADP
dti-2103	131	46	udp	udp	NOUN
dti-2103	131	47	treatments	treatment	NOUN
dti-2103	131	48	.	.	PUNCT
dti-2103	132	1	the	the	DET
dti-2103	132	2	p	p	PROPN
dti-2103	132	3	values	value	NOUN
dti-2103	132	4	calculated	calculate	VERB
dti-2103	132	5	in	in	ADP
dti-2103	132	6	comparison	comparison	NOUN
dti-2103	132	7	to	to	ADP
dti-2103	132	8	control	control	NOUN
dti-2103	132	9	(	(	PUNCT
dti-2103	132	10	untreated	untreated	ADJ
dti-2103	132	11	)	)	PUNCT
dti-2103	132	12	.	.	PUNCT
dti-2103	133	1	(	(	PUNCT
dti-2103	133	2	d	d	X
dti-2103	133	3	)	)	PUNCT
dti-2103	133	4	western	western	ADJ
dti-2103	133	5	blot	blot	NOUN
dti-2103	133	6	analysis	analysis	NOUN
dti-2103	133	7	of	of	ADP
dti-2103	133	8	ugp2	ugp2	NOUN
dti-2103	133	9	in	in	ADP
dti-2103	133	10	a549	a549	PROPN
dti-2103	133	11	cell	cell	NOUN
dti-2103	133	12	lysate	lysate	NOUN
dti-2103	133	13	,	,	PUNCT
dti-2103	133	14	*	*	PUNCT
dti-2103	133	15	p	p	X
dti-2103	133	16	<	<	X
dti-2103	133	17	0.05	0.05	NUM
dti-2103	133	18	,	,	PUNCT
dti-2103	133	19	*	*	PUNCT
dti-2103	133	20	*	*	PUNCT
dti-2103	133	21	p	p	X
dti-2103	133	22	<	<	X
dti-2103	133	23	0.01	0.01	NUM
dti-2103	133	24	.	.	PUNCT
dti-2103	134	1	a	a	DET
dti-2103	134	2	c	c	NOUN
dti-2103	134	3	b	b	PROPN
dti-2103	134	4	d	d	X
dti-2103	134	5	ugpase	ugpase	NOUN
dti-2103	134	6	-	-	PUNCT
dti-2103	134	7	mediated	mediate	VERB
dti-2103	134	8	streptococcus	streptococcus	NOUN
dti-2103	134	9	pneumoniae	pneumoniae	ADJ
dti-2103	134	10	virulence30	virulence30	NOUN
dti-2103	134	11	©	©	ADP
dti-2103	134	12	2020	2020	NUM
dti-2103	135	1	the	the	DET
dti-2103	135	2	authors	author	NOUN
dti-2103	135	3	.	.	PUNCT
dti-2103	135	4	published	publish	VERB
dti-2103	135	5	by	by	ADP
dti-2103	135	6	aboutscience	aboutscience	NOUN
dti-2103	135	7	effect	effect	NOUN
dti-2103	135	8	of	of	ADP
dti-2103	135	9	udp	udp	NOUN
dti-2103	135	10	on	on	ADP
dti-2103	135	11	s.	s.	PROPN
dti-2103	135	12	pneumoniae	pneumoniae	ADJ
dti-2103	135	13	adherence	adherence	NOUN
dti-2103	135	14	all	all	DET
dti-2103	135	15	s.	s.	PROPN
dti-2103	135	16	pneumoniae	pneumoniae	ADJ
dti-2103	135	17	strains	strain	NOUN
dti-2103	135	18	showed	show	VERB
dti-2103	135	19	a	a	DET
dti-2103	135	20	decrease	decrease	NOUN
dti-2103	135	21	in	in	ADP
dti-2103	135	22	adherence	adherence	NOUN
dti-2103	135	23	to	to	ADP
dti-2103	135	24	a549	a549	PROPN
dti-2103	135	25	(	(	PUNCT
dti-2103	135	26	p	p	NOUN
dti-2103	135	27	=	=	NOUN
dti-2103	135	28	0.018	0.018	NUM
dti-2103	135	29	)	)	PUNCT
dti-2103	135	30	and	and	CCONJ
dti-2103	135	31	hep-2	hep-2	PUNCT
dti-2103	135	32	cells	cell	NOUN
dti-2103	135	33	(	(	PUNCT
dti-2103	135	34	p	p	NOUN
dti-2103	135	35	=	=	NOUN
dti-2103	135	36	0.001	0.001	NUM
dti-2103	135	37	)	)	PUNCT
dti-2103	135	38	in	in	ADP
dti-2103	135	39	the	the	DET
dti-2103	135	40	presence	presence	NOUN
dti-2103	135	41	of	of	ADP
dti-2103	135	42	5	5	NUM
dti-2103	135	43	μm	μm	NOUN
dti-2103	135	44	udp	udp	NOUN
dti-2103	135	45	(	(	PUNCT
dti-2103	135	46	fig	fig	NOUN
dti-2103	135	47	.	.	PUNCT
dti-2103	136	1	3	3	NUM
dti-2103	136	2	)	)	PUNCT
dti-2103	136	3	.	.	PUNCT
dti-2103	137	1	adherence	adherence	NOUN
dti-2103	137	2	of	of	ADP
dti-2103	137	3	mtcc	mtcc	NOUN
dti-2103	137	4	655	655	NUM
dti-2103	137	5	and	and	CCONJ
dti-2103	137	6	blood	blood	NOUN
dti-2103	137	7	isolate	isolate	NOUN
dti-2103	137	8	was	be	AUX
dti-2103	137	9	significantly	significantly	ADV
dti-2103	137	10	(	(	PUNCT
dti-2103	137	11	p<0.05	p<0.05	NOUN
dti-2103	137	12	)	)	PUNCT
dti-2103	137	13	lowered	lower	VERB
dti-2103	137	14	in	in	ADP
dti-2103	137	15	both	both	CCONJ
dti-2103	137	16	the	the	DET
dti-2103	137	17	cell	cell	NOUN
dti-2103	137	18	lines	line	NOUN
dti-2103	137	19	(	(	PUNCT
dti-2103	137	20	fig	fig	NOUN
dti-2103	137	21	.	.	PUNCT
dti-2103	138	1	3a	3a	NUM
dti-2103	138	2	and	and	CCONJ
dti-2103	138	3	b	b	X
dti-2103	138	4	)	)	PUNCT
dti-2103	138	5	,	,	PUNCT
dti-2103	138	6	while	while	SCONJ
dti-2103	138	7	d39	d39	NOUN
dti-2103	138	8	showed	show	VERB
dti-2103	138	9	a	a	DET
dti-2103	138	10	significant	significant	ADJ
dti-2103	138	11	(	(	PUNCT
dti-2103	138	12	p	p	X
dti-2103	138	13	=	=	SYM
dti-2103	138	14	0.031	0.031	NUM
dti-2103	138	15	)	)	PUNCT
dti-2103	138	16	decrease	decrease	NOUN
dti-2103	138	17	in	in	ADP
dti-2103	138	18	hep-2	hep-2	PUNCT
dti-2103	138	19	cells	cell	NOUN
dti-2103	138	20	only	only	ADV
dti-2103	138	21	(	(	PUNCT
dti-2103	138	22	fig	fig	NOUN
dti-2103	138	23	.	.	PUNCT
dti-2103	139	1	3b	3b	NUM
dti-2103	139	2	)	)	PUNCT
dti-2103	139	3	.	.	PUNCT
dti-2103	140	1	adherence	adherence	NOUN
dti-2103	140	2	of	of	ADP
dti-2103	140	3	blood	blood	NOUN
dti-2103	140	4	isolate	isolate	NOUN
dti-2103	140	5	to	to	ADP
dti-2103	140	6	a549	a549	PROPN
dti-2103	140	7	(	(	PUNCT
dti-2103	140	8	p	p	X
dti-2103	140	9	=	=	NOUN
dti-2103	140	10	0.032	0.032	NUM
dti-2103	140	11	)	)	PUNCT
dti-2103	140	12	and	and	CCONJ
dti-2103	140	13	hep-2	hep-2	PUNCT
dti-2103	140	14	(	(	PUNCT
dti-2103	140	15	p	p	X
dti-2103	140	16	=	=	NOUN
dti-2103	140	17	0.014	0.014	NUM
dti-2103	140	18	)	)	PUNCT
dti-2103	140	19	cells	cell	NOUN
dti-2103	140	20	declined	decline	VERB
dti-2103	140	21	by	by	ADP
dti-2103	140	22	threeto	threeto	NOUN
dti-2103	140	23	fivefold	fivefold	ADV
dti-2103	140	24	.	.	PUNCT
dti-2103	141	1	effect	effect	NOUN
dti-2103	141	2	of	of	ADP
dti-2103	141	3	udp	udp	NOUN
dti-2103	141	4	on	on	ADP
dti-2103	141	5	phagocytosis	phagocytosis	NOUN
dti-2103	141	6	of	of	ADP
dti-2103	141	7	s.	s.	PROPN
dti-2103	141	8	pneumoniae	pneumoniae	ADP
dti-2103	141	9	the	the	DET
dti-2103	141	10	phagocytosis	phagocytosis	NOUN
dti-2103	141	11	of	of	ADP
dti-2103	141	12	s.	s.	PROPN
dti-2103	141	13	pneumoniae	pneumoniae	PROPN
dti-2103	141	14	was	be	AUX
dti-2103	141	15	increased	increase	VERB
dti-2103	141	16	in	in	ADP
dti-2103	141	17	the	the	DET
dti-2103	141	18	presence	presence	NOUN
dti-2103	141	19	of	of	ADP
dti-2103	141	20	udp	udp	NOUN
dti-2103	141	21	in	in	ADP
dti-2103	141	22	both	both	DET
dti-2103	141	23	j774.a.1	j774.a.1	PROPN
dti-2103	141	24	(	(	PUNCT
dti-2103	141	25	p	p	X
dti-2103	141	26	=	=	NOUN
dti-2103	141	27	0.01	0.01	NUM
dti-2103	141	28	)	)	PUNCT
dti-2103	141	29	and	and	CCONJ
dti-2103	141	30	thp1	thp1	NOUN
dti-2103	141	31	(	(	PUNCT
dti-2103	141	32	p	p	X
dti-2103	141	33	=	=	NOUN
dti-2103	141	34	0.022	0.022	NUM
dti-2103	141	35	)	)	PUNCT
dti-2103	141	36	cells	cell	NOUN
dti-2103	141	37	(	(	PUNCT
dti-2103	141	38	fig	fig	NOUN
dti-2103	141	39	.	.	PUNCT
dti-2103	142	1	4a	4a	NOUN
dti-2103	142	2	and	and	CCONJ
dti-2103	142	3	b	b	NOUN
dti-2103	142	4	respectively	respectively	ADV
dti-2103	142	5	)	)	PUNCT
dti-2103	142	6	.	.	PUNCT
dti-2103	143	1	phagocytosis	phagocytosis	NOUN
dti-2103	143	2	of	of	ADP
dti-2103	143	3	d39	d39	NOUN
dti-2103	143	4	strain	strain	NOUN
dti-2103	143	5	was	be	AUX
dti-2103	143	6	significantly	significantly	ADV
dti-2103	143	7	higher	high	ADJ
dti-2103	143	8	than	than	ADP
dti-2103	143	9	mtcc	mtcc	NOUN
dti-2103	143	10	655	655	NUM
dti-2103	143	11	strain	strain	NOUN
dti-2103	143	12	(	(	PUNCT
dti-2103	143	13	p	p	X
dti-2103	143	14	=	=	NOUN
dti-2103	143	15	0.033	0.033	NUM
dti-2103	143	16	)	)	PUNCT
dti-2103	143	17	in	in	ADP
dti-2103	143	18	both	both	CCONJ
dti-2103	143	19	the	the	DET
dti-2103	143	20	cell	cell	NOUN
dti-2103	143	21	lines	line	NOUN
dti-2103	143	22	,	,	PUNCT
dti-2103	143	23	which	which	PRON
dti-2103	143	24	could	could	AUX
dti-2103	143	25	be	be	AUX
dti-2103	143	26	attributed	attribute	VERB
dti-2103	143	27	to	to	ADP
dti-2103	143	28	heavy	heavy	ADJ
dti-2103	143	29	encapsulation	encapsulation	NOUN
dti-2103	143	30	in	in	ADP
dti-2103	143	31	the	the	DET
dti-2103	143	32	latter	latter	ADJ
dti-2103	143	33	.	.	PUNCT
dti-2103	144	1	udp	udp	NOUN
dti-2103	144	2	treatment	treatment	NOUN
dti-2103	144	3	also	also	ADV
dti-2103	144	4	showed	show	VERB
dti-2103	144	5	an	an	DET
dti-2103	144	6	increase	increase	NOUN
dti-2103	144	7	in	in	ADP
dti-2103	144	8	phagocytosis	phagocytosis	NOUN
dti-2103	144	9	of	of	ADP
dti-2103	144	10	blood	blood	NOUN
dti-2103	144	11	isolate	isolate	NOUN
dti-2103	144	12	by	by	ADP
dti-2103	144	13	j774.a.1	j774.a.1	PROPN
dti-2103	144	14	(	(	PUNCT
dti-2103	144	15	p	p	X
dti-2103	144	16	=	=	NOUN
dti-2103	144	17	0.034	0.034	NUM
dti-2103	144	18	)	)	PUNCT
dti-2103	144	19	and	and	CCONJ
dti-2103	144	20	thp1	thp1	NOUN
dti-2103	144	21	cells	cell	NOUN
dti-2103	144	22	(	(	PUNCT
dti-2103	144	23	p	p	X
dti-2103	144	24	=	=	NOUN
dti-2103	144	25	0.041	0.041	NUM
dti-2103	144	26	)	)	PUNCT
dti-2103	144	27	.	.	PUNCT
dti-2103	145	1	overall	overall	ADV
dti-2103	145	2	,	,	PUNCT
dti-2103	145	3	udp	udp	NOUN
dti-2103	145	4	-	-	ADJ
dti-2103	145	5	dependent	dependent	ADJ
dti-2103	145	6	fold	fold	NOUN
dti-2103	145	7	change	change	NOUN
dti-2103	145	8	in	in	ADP
dti-2103	145	9	phagocytosis	phagocytosis	NOUN
dti-2103	145	10	ranged	range	VERB
dti-2103	145	11	from	from	ADP
dti-2103	145	12	1.4	1.4	NUM
dti-2103	145	13	to	to	ADP
dti-2103	145	14	1.9	1.9	NUM
dti-2103	145	15	for	for	ADP
dti-2103	145	16	pneumococcal	pneumococcal	ADJ
dti-2103	145	17	strains	strain	NOUN
dti-2103	145	18	.	.	PUNCT
dti-2103	146	1	it	it	PRON
dti-2103	146	2	is	be	AUX
dti-2103	146	3	well	well	ADV
dti-2103	146	4	known	know	VERB
dti-2103	146	5	that	that	SCONJ
dti-2103	146	6	host	host	NOUN
dti-2103	146	7	immune	immune	ADJ
dti-2103	146	8	cells	cell	NOUN
dti-2103	146	9	use	use	VERB
dti-2103	146	10	complement	complement	NOUN
dti-2103	146	11	factors	factor	NOUN
dti-2103	146	12	for	for	ADP
dti-2103	146	13	the	the	DET
dti-2103	146	14	clearance	clearance	NOUN
dti-2103	146	15	of	of	ADP
dti-2103	146	16	s.	s.	PROPN
dti-2103	146	17	pneumoniae	pneumoniae	PROPN
dti-2103	146	18	,	,	PUNCT
dti-2103	146	19	and	and	CCONJ
dti-2103	146	20	opa	opa	NOUN
dti-2103	146	21	of	of	ADP
dti-2103	146	22	heat	heat	NOUN
dti-2103	146	23	-	-	PUNCT
dti-2103	146	24	inactivated	inactivate	VERB
dti-2103	146	25	s.	s.	PROPN
dti-2103	146	26	pneumoniae	pneumoniae	NOUN
dti-2103	146	27	was	be	AUX
dti-2103	146	28	found	find	VERB
dti-2103	146	29	to	to	PART
dti-2103	146	30	be	be	AUX
dti-2103	146	31	enhanced	enhance	VERB
dti-2103	146	32	in	in	ADP
dti-2103	146	33	the	the	DET
dti-2103	146	34	presence	presence	NOUN
dti-2103	146	35	of	of	ADP
dti-2103	146	36	udp	udp	NOUN
dti-2103	146	37	in	in	ADP
dti-2103	146	38	both	both	CCONJ
dti-2103	146	39	the	the	DET
dti-2103	146	40	cell	cell	NOUN
dti-2103	146	41	lines	line	NOUN
dti-2103	146	42	(	(	PUNCT
dti-2103	146	43	fig	fig	NOUN
dti-2103	146	44	.	.	PUNCT
dti-2103	147	1	5a	5a	NUM
dti-2103	147	2	and	and	CCONJ
dti-2103	147	3	b	b	NOUN
dti-2103	147	4	)	)	PUNCT
dti-2103	147	5	.	.	PUNCT
dti-2103	148	1	interestingly	interestingly	ADV
dti-2103	148	2	,	,	PUNCT
dti-2103	148	3	j774.a.1	j774.a.1	PROPN
dti-2103	148	4	cells	cell	NOUN
dti-2103	148	5	(	(	PUNCT
dti-2103	148	6	fig	fig	NOUN
dti-2103	148	7	.	.	PUNCT
dti-2103	149	1	5a	5a	NUM
dti-2103	149	2	)	)	PUNCT
dti-2103	149	3	showed	show	VERB
dti-2103	149	4	marked	marked	ADJ
dti-2103	149	5	increase	increase	NOUN
dti-2103	149	6	in	in	ADP
dti-2103	149	7	the	the	DET
dti-2103	149	8	opa	opa	NOUN
dti-2103	149	9	of	of	ADP
dti-2103	149	10	blood	blood	NOUN
dti-2103	149	11	isolate	isolate	NOUN
dti-2103	149	12	than	than	ADP
dti-2103	149	13	mtcc	mtcc	NOUN
dti-2103	149	14	655	655	NUM
dti-2103	149	15	and	and	CCONJ
dti-2103	149	16	d39	d39	NOUN
dti-2103	149	17	strains	strain	NOUN
dti-2103	149	18	.	.	PUNCT
dti-2103	150	1	phagocytosis	phagocytosis	NOUN
dti-2103	150	2	of	of	ADP
dti-2103	150	3	mtcc	mtcc	NOUN
dti-2103	150	4	655	655	NUM
dti-2103	150	5	and	and	CCONJ
dti-2103	150	6	d39	d39	NOUN
dti-2103	150	7	strains	strain	NOUN
dti-2103	150	8	was	be	AUX
dti-2103	150	9	higher	high	ADJ
dti-2103	150	10	in	in	ADP
dti-2103	150	11	thp1	thp1	NOUN
dti-2103	150	12	cells	cell	NOUN
dti-2103	150	13	(	(	PUNCT
dti-2103	150	14	fig	fig	NOUN
dti-2103	150	15	.	.	PUNCT
dti-2103	151	1	5b	5b	NUM
dti-2103	151	2	)	)	PUNCT
dti-2103	151	3	in	in	ADP
dti-2103	151	4	the	the	DET
dti-2103	151	5	presence	presence	NOUN
dti-2103	151	6	of	of	ADP
dti-2103	151	7	udp	udp	NOUN
dti-2103	151	8	(	(	PUNCT
dti-2103	151	9	5	5	NUM
dti-2103	151	10	μm	μm	NUM
dti-2103	151	11	)	)	PUNCT
dti-2103	151	12	and	and	CCONJ
dti-2103	151	13	sera	sera	NOUN
dti-2103	151	14	.	.	PUNCT
dti-2103	152	1	real	real	ADJ
dti-2103	152	2	-	-	PUNCT
dti-2103	152	3	time	time	NOUN
dti-2103	152	4	pcr	pcr	ADJ
dti-2103	152	5	analysis	analysis	NOUN
dti-2103	152	6	of	of	ADP
dti-2103	152	7	cytokines	cytokine	NOUN
dti-2103	152	8	an	an	DET
dti-2103	152	9	attempt	attempt	NOUN
dti-2103	152	10	was	be	AUX
dti-2103	152	11	made	make	VERB
dti-2103	152	12	to	to	PART
dti-2103	152	13	evaluate	evaluate	VERB
dti-2103	152	14	the	the	DET
dti-2103	152	15	cytokine	cytokine	ADJ
dti-2103	152	16	response	response	NOUN
dti-2103	152	17	in	in	ADP
dti-2103	152	18	a549	a549	PROPN
dti-2103	152	19	cells	cell	NOUN
dti-2103	152	20	in	in	ADP
dti-2103	152	21	response	response	NOUN
dti-2103	152	22	to	to	AUX
dti-2103	152	23	udp	udp	VERB
dti-2103	152	24	treatment	treatment	NOUN
dti-2103	152	25	as	as	ADP
dti-2103	152	26	previous	previous	ADJ
dti-2103	152	27	studies	study	NOUN
dti-2103	152	28	have	have	AUX
dti-2103	152	29	shown	show	VERB
dti-2103	152	30	the	the	DET
dti-2103	152	31	activation	activation	NOUN
dti-2103	152	32	of	of	ADP
dti-2103	152	33	inflammatory	inflammatory	ADJ
dti-2103	152	34	pathway	pathway	NOUN
dti-2103	152	35	upon	upon	SCONJ
dti-2103	152	36	udp	udp	NOUN
dti-2103	152	37	stimulation	stimulation	NOUN
dti-2103	152	38	from	from	ADP
dti-2103	152	39	monocytes	monocyte	NOUN
dti-2103	152	40	and	and	CCONJ
dti-2103	152	41	microglial	microglial	ADJ
dti-2103	152	42	cells	cell	NOUN
dti-2103	152	43	(	(	PUNCT
dti-2103	152	44	28,29	28,29	NUM
dti-2103	152	45	)	)	PUNCT
dti-2103	152	46	.	.	PUNCT
dti-2103	153	1	interestingly	interestingly	ADV
dti-2103	153	2	,	,	PUNCT
dti-2103	153	3	udp	udp	NOUN
dti-2103	153	4	treatment	treatment	NOUN
dti-2103	153	5	(	(	PUNCT
dti-2103	153	6	5	5	NUM
dti-2103	153	7	μm	μm	NOUN
dti-2103	153	8	)	)	PUNCT
dti-2103	153	9	induced	induce	VERB
dti-2103	153	10	the	the	DET
dti-2103	153	11	secretion	secretion	NOUN
dti-2103	153	12	of	of	ADP
dti-2103	153	13	a	a	DET
dti-2103	153	14	b	b	NOUN
dti-2103	153	15	fig	fig	NOUN
dti-2103	153	16	.	.	PUNCT
dti-2103	154	1	2	2	NUM
dti-2103	154	2	effect	effect	NOUN
dti-2103	154	3	of	of	ADP
dti-2103	154	4	uridine	uridine	NOUN
dti-2103	154	5	diphosphate	diphosphate	NOUN
dti-2103	154	6	(	(	PUNCT
dti-2103	154	7	udp	udp	NOUN
dti-2103	154	8	)	)	PUNCT
dti-2103	154	9	treatment	treatment	NOUN
dti-2103	154	10	on	on	ADP
dti-2103	154	11	a549	a549	PROPN
dti-2103	154	12	cell	cell	NOUN
dti-2103	154	13	survival	survival	NOUN
dti-2103	154	14	.	.	PUNCT
dti-2103	155	1	(	(	PUNCT
dti-2103	155	2	a	a	X
dti-2103	155	3	)	)	PUNCT
dti-2103	155	4	treatment	treatment	NOUN
dti-2103	155	5	-	-	PUNCT
dti-2103	155	6	response	response	NOUN
dti-2103	155	7	curve	curve	NOUN
dti-2103	155	8	of	of	ADP
dti-2103	155	9	cells	cell	NOUN
dti-2103	155	10	infected	infect	VERB
dti-2103	155	11	with	with	ADP
dti-2103	155	12	s.	s.	PROPN
dti-2103	155	13	pneumoniae	pneumoniae	PROPN
dti-2103	155	14	,	,	PUNCT
dti-2103	155	15	(	(	PUNCT
dti-2103	155	16	b	b	X
dti-2103	155	17	)	)	PUNCT
dti-2103	155	18	comparative	comparative	ADJ
dti-2103	155	19	analysis	analysis	NOUN
dti-2103	155	20	of	of	ADP
dti-2103	155	21	udp	udp	NOUN
dti-2103	155	22	treated	treat	VERB
dti-2103	155	23	and	and	CCONJ
dti-2103	155	24	untreated	untreated	ADJ
dti-2103	155	25	(	(	PUNCT
dti-2103	155	26	0	0	NUM
dti-2103	155	27	µm	µm	NOUN
dti-2103	155	28	)	)	PUNCT
dti-2103	155	29	cells	cell	NOUN
dti-2103	155	30	,	,	PUNCT
dti-2103	155	31	control	control	NOUN
dti-2103	155	32	:	:	PUNCT
dti-2103	155	33	uninfected	uninfecte	VERB
dti-2103	155	34	a549	a549	PROPN
dti-2103	155	35	cells	cell	NOUN
dti-2103	155	36	,	,	PUNCT
dti-2103	155	37	*	*	PUNCT
dti-2103	155	38	p	p	X
dti-2103	155	39	<	<	X
dti-2103	155	40	0.05	0.05	NUM
dti-2103	155	41	,	,	PUNCT
dti-2103	155	42	*	*	PUNCT
dti-2103	155	43	*	*	PUNCT
dti-2103	155	44	p	p	X
dti-2103	155	45	<	<	X
dti-2103	155	46	0.01	0.01	NUM
dti-2103	155	47	.	.	PUNCT
dti-2103	156	1	fig	fig	NOUN
dti-2103	156	2	.	.	PUNCT
dti-2103	157	1	3	3	NUM
dti-2103	157	2	effect	effect	NOUN
dti-2103	157	3	of	of	ADP
dti-2103	157	4	uridine	uridine	NOUN
dti-2103	157	5	diphosphate	diphosphate	NOUN
dti-2103	157	6	(	(	PUNCT
dti-2103	157	7	udp	udp	NOUN
dti-2103	157	8	)	)	PUNCT
dti-2103	157	9	treatment	treatment	NOUN
dti-2103	157	10	on	on	ADP
dti-2103	157	11	adherence	adherence	NOUN
dti-2103	157	12	of	of	ADP
dti-2103	157	13	s.	s.	PROPN
dti-2103	157	14	pneumoniae	pneumoniae	ADV
dti-2103	157	15	by	by	ADP
dti-2103	157	16	(	(	PUNCT
dti-2103	157	17	a	a	NOUN
dti-2103	157	18	)	)	PUNCT
dti-2103	157	19	a549	a549	PROPN
dti-2103	157	20	and	and	CCONJ
dti-2103	157	21	(	(	PUNCT
dti-2103	157	22	b	b	NOUN
dti-2103	157	23	)	)	PUNCT
dti-2103	157	24	hep-2	hep-2	PUNCT
dti-2103	157	25	cells	cell	NOUN
dti-2103	157	26	,	,	PUNCT
dti-2103	157	27	*	*	PUNCT
dti-2103	157	28	p	p	X
dti-2103	157	29	<	<	X
dti-2103	157	30	0.05	0.05	NUM
dti-2103	157	31	.	.	PUNCT
dti-2103	158	1	a	a	DET
dti-2103	158	2	b	b	PROPN
dti-2103	158	3	sharma	sharma	PROPN
dti-2103	158	4	et	et	PROPN
dti-2103	158	5	al	al	PROPN
dti-2103	158	6	31	31	NUM
dti-2103	158	7	©	©	PROPN
dti-2103	158	8	2020	2020	NUM
dti-2103	158	9	the	the	DET
dti-2103	158	10	authors	author	NOUN
dti-2103	158	11	.	.	PUNCT
dti-2103	159	1	published	publish	VERB
dti-2103	159	2	by	by	ADP
dti-2103	159	3	aboutscience	aboutscience	NOUN
dti-2103	159	4	a	a	DET
dti-2103	159	5	a	a	DET
dti-2103	159	6	b	b	PROPN
dti-2103	159	7	b	b	X
dti-2103	159	8	fig	fig	NOUN
dti-2103	159	9	.	.	PUNCT
dti-2103	160	1	6	6	NUM
dti-2103	160	2	relative	relative	ADJ
dti-2103	160	3	messenger	messenger	NOUN
dti-2103	160	4	ribonucleic	ribonucleic	ADJ
dti-2103	160	5	acid	acid	PROPN
dti-2103	160	6	(	(	PUNCT
dti-2103	160	7	mrna	mrna	PROPN
dti-2103	160	8	)	)	PUNCT
dti-2103	160	9	expression	expression	NOUN
dti-2103	160	10	of	of	ADP
dti-2103	160	11	cytokines	cytokine	NOUN
dti-2103	160	12	induced	induce	VERB
dti-2103	160	13	in	in	ADP
dti-2103	160	14	a549	a549	PROPN
dti-2103	160	15	cells	cell	NOUN
dti-2103	160	16	,	,	PUNCT
dti-2103	160	17	mrs2578	mrs2578	NUM
dti-2103	160	18	:	:	PUNCT
dti-2103	160	19	antagonist	antagonist	NOUN
dti-2103	160	20	of	of	ADP
dti-2103	160	21	uridine	uridine	NOUN
dti-2103	160	22	diphosphate	diphosphate	NOUN
dti-2103	160	23	(	(	PUNCT
dti-2103	160	24	udp	udp	PROPN
dti-2103	160	25	)	)	PUNCT
dti-2103	160	26	.	.	PUNCT
dti-2103	161	1	fig	fig	NOUN
dti-2103	161	2	.	.	PUNCT
dti-2103	162	1	4	4	NUM
dti-2103	162	2	effect	effect	NOUN
dti-2103	162	3	of	of	ADP
dti-2103	162	4	uridine	uridine	NOUN
dti-2103	162	5	diphosphate	diphosphate	NOUN
dti-2103	162	6	(	(	PUNCT
dti-2103	162	7	udp	udp	PROPN
dti-2103	162	8	,	,	PUNCT
dti-2103	162	9	5	5	NUM
dti-2103	162	10	µm	µm	NOUN
dti-2103	162	11	)	)	PUNCT
dti-2103	162	12	on	on	ADP
dti-2103	162	13	phagocytosis	phagocytosis	NOUN
dti-2103	162	14	of	of	ADP
dti-2103	162	15	s.	s.	PROPN
dti-2103	162	16	pneumoniae	pneumoniae	ADV
dti-2103	162	17	by	by	ADP
dti-2103	162	18	(	(	PUNCT
dti-2103	162	19	a	a	NOUN
dti-2103	162	20	)	)	PUNCT
dti-2103	162	21	j774.a.1	j774.a.1	PROPN
dti-2103	162	22	and	and	CCONJ
dti-2103	162	23	(	(	PUNCT
dti-2103	162	24	b	b	NOUN
dti-2103	162	25	)	)	PUNCT
dti-2103	162	26	thp1	thp1	NOUN
dti-2103	162	27	cells	cell	NOUN
dti-2103	162	28	,	,	PUNCT
dti-2103	162	29	*	*	PUNCT
dti-2103	162	30	p	p	X
dti-2103	162	31	<	<	X
dti-2103	162	32	0.05	0.05	NUM
dti-2103	162	33	,	,	PUNCT
dti-2103	162	34	*	*	PUNCT
dti-2103	162	35	*	*	PUNCT
dti-2103	162	36	p	p	X
dti-2103	162	37	<	<	X
dti-2103	162	38	0.01	0.01	NUM
dti-2103	162	39	.	.	PUNCT
dti-2103	162	40	fig	fig	NOUN
dti-2103	162	41	.	.	PUNCT
dti-2103	163	1	5	5	NUM
dti-2103	163	2	effect	effect	NOUN
dti-2103	163	3	of	of	ADP
dti-2103	163	4	uridine	uridine	NOUN
dti-2103	163	5	diphosphate	diphosphate	NOUN
dti-2103	163	6	(	(	PUNCT
dti-2103	163	7	udp	udp	PROPN
dti-2103	163	8	,	,	PUNCT
dti-2103	163	9	5	5	NUM
dti-2103	163	10	µm	µm	NOUN
dti-2103	163	11	)	)	PUNCT
dti-2103	163	12	on	on	ADP
dti-2103	163	13	opsonophagocytosis	opsonophagocytosis	NOUN
dti-2103	163	14	of	of	ADP
dti-2103	163	15	s.	s.	PROPN
dti-2103	163	16	pneumoniae	pneumoniae	ADV
dti-2103	163	17	by	by	ADP
dti-2103	163	18	(	(	PUNCT
dti-2103	163	19	a	a	NOUN
dti-2103	163	20	)	)	PUNCT
dti-2103	163	21	j774.a.1	j774.a.1	PROPN
dti-2103	163	22	and	and	CCONJ
dti-2103	163	23	(	(	PUNCT
dti-2103	163	24	b	b	NOUN
dti-2103	163	25	)	)	PUNCT
dti-2103	163	26	thp1	thp1	NOUN
dti-2103	163	27	cells	cell	NOUN
dti-2103	163	28	,	,	PUNCT
dti-2103	163	29	*	*	PUNCT
dti-2103	163	30	p	p	X
dti-2103	163	31	<	<	X
dti-2103	163	32	0.05	0.05	NUM
dti-2103	163	33	,	,	PUNCT
dti-2103	163	34	*	*	PUNCT
dti-2103	163	35	*	*	PUNCT
dti-2103	163	36	p	p	X
dti-2103	163	37	<	<	X
dti-2103	163	38	0.01	0.01	NUM
dti-2103	163	39	,	,	PUNCT
dti-2103	163	40	*	*	PUNCT
dti-2103	163	41	*	*	PUNCT
dti-2103	163	42	*	*	PUNCT
dti-2103	163	43	p	p	X
dti-2103	163	44	<	<	X
dti-2103	163	45	0.001	0.001	NUM
dti-2103	163	46	.	.	PUNCT
dti-2103	164	1	il-1β	il-1β	PROPN
dti-2103	164	2	,	,	PUNCT
dti-2103	164	3	tnf	tnf	PROPN
dti-2103	164	4	-	-	PUNCT
dti-2103	164	5	α	α	PROPN
dti-2103	164	6	,	,	PUNCT
dti-2103	164	7	il-6	il-6	NOUN
dti-2103	164	8	,	,	PUNCT
dti-2103	164	9	and	and	CCONJ
dti-2103	164	10	il-8	il-8	ADP
dti-2103	164	11	from	from	ADP
dti-2103	164	12	the	the	DET
dti-2103	164	13	a549	a549	PROPN
dti-2103	164	14	alveolar	alveolar	ADJ
dti-2103	164	15	epithelial	epithelial	ADJ
dti-2103	164	16	cells	cell	NOUN
dti-2103	164	17	(	(	PUNCT
dti-2103	164	18	fig	fig	NOUN
dti-2103	164	19	.	.	PUNCT
dti-2103	165	1	6	6	NUM
dti-2103	165	2	)	)	PUNCT
dti-2103	165	3	.	.	PUNCT
dti-2103	166	1	an	an	DET
dti-2103	166	2	udp	udp	NOUN
dti-2103	166	3	antagonist	antagonist	NOUN
dti-2103	166	4	mrs2578	mrs2578	PROPN
dti-2103	166	5	(	(	PUNCT
dti-2103	166	6	sigma	sigma	PROPN
dti-2103	166	7	)	)	PUNCT
dti-2103	166	8	effectively	effectively	ADV
dti-2103	166	9	suppressed	suppress	VERB
dti-2103	166	10	the	the	DET
dti-2103	166	11	expression	expression	NOUN
dti-2103	166	12	of	of	ADP
dti-2103	166	13	these	these	DET
dti-2103	166	14	cytokines	cytokine	NOUN
dti-2103	166	15	in	in	ADP
dti-2103	166	16	a549	a549	PROPN
dti-2103	166	17	cells	cell	NOUN
dti-2103	166	18	.	.	PUNCT
dti-2103	167	1	in	in	ADP
dti-2103	167	2	agreement	agreement	NOUN
dti-2103	167	3	with	with	ADP
dti-2103	167	4	these	these	DET
dti-2103	167	5	results	result	NOUN
dti-2103	167	6	,	,	PUNCT
dti-2103	167	7	udp	udp	NOUN
dti-2103	167	8	is	be	AUX
dti-2103	167	9	shown	show	VERB
dti-2103	167	10	to	to	PART
dti-2103	167	11	bind	bind	VERB
dti-2103	167	12	its	its	PRON
dti-2103	167	13	purinergic	purinergic	NOUN
dti-2103	167	14	receptor	receptor	NOUN
dti-2103	167	15	p2y6	p2y6	NOUN
dti-2103	167	16	on	on	ADP
dti-2103	167	17	various	various	ADJ
dti-2103	167	18	cells	cell	NOUN
dti-2103	167	19	and	and	CCONJ
dti-2103	167	20	stimulate	stimulate	VERB
dti-2103	167	21	signaling	signal	VERB
dti-2103	167	22	cascade	cascade	NOUN
dti-2103	167	23	(	(	PUNCT
dti-2103	167	24	30,31	30,31	NUM
dti-2103	167	25	)	)	PUNCT
dti-2103	167	26	.	.	PUNCT
dti-2103	168	1	conclusions	conclusion	NOUN
dti-2103	168	2	the	the	DET
dti-2103	168	3	paradox	paradox	NOUN
dti-2103	168	4	of	of	ADP
dti-2103	168	5	infections	infection	NOUN
dti-2103	168	6	caused	cause	VERB
dti-2103	168	7	by	by	ADP
dti-2103	168	8	s.	s.	PROPN
dti-2103	168	9	pneumoniae	pneumoniae	PROPN
dti-2103	168	10	lies	lie	NOUN
dti-2103	168	11	in	in	ADP
dti-2103	168	12	the	the	DET
dti-2103	168	13	availability	availability	NOUN
dti-2103	168	14	of	of	ADP
dti-2103	168	15	preventive	preventive	ADJ
dti-2103	168	16	measures	measure	NOUN
dti-2103	168	17	such	such	ADJ
dti-2103	168	18	as	as	ADP
dti-2103	168	19	antibiotics	antibiotic	NOUN
dti-2103	168	20	and	and	CCONJ
dti-2103	168	21	vaccines	vaccine	NOUN
dti-2103	168	22	,	,	PUNCT
dti-2103	168	23	but	but	CCONJ
dti-2103	168	24	not	not	PART
dti-2103	168	25	effective	effective	ADJ
dti-2103	168	26	prevention	prevention	NOUN
dti-2103	168	27	from	from	ADP
dti-2103	168	28	the	the	DET
dti-2103	168	29	pneumococcal	pneumococcal	ADJ
dti-2103	168	30	diseases	disease	NOUN
dti-2103	168	31	,	,	PUNCT
dti-2103	168	32	especially	especially	ADV
dti-2103	168	33	in	in	ADP
dti-2103	168	34	lowto	lowto	NOUN
dti-2103	168	35	middle	middle	ADJ
dti-2103	168	36	-	-	PUNCT
dti-2103	168	37	income	income	NOUN
dti-2103	168	38	settings	setting	NOUN
dti-2103	168	39	.	.	PUNCT
dti-2103	169	1	the	the	DET
dti-2103	169	2	major	major	ADJ
dti-2103	169	3	reason	reason	NOUN
dti-2103	169	4	for	for	ADP
dti-2103	169	5	this	this	DET
dti-2103	169	6	paradox	paradox	NOUN
dti-2103	169	7	is	be	AUX
dti-2103	169	8	the	the	DET
dti-2103	169	9	genome	genome	NOUN
dti-2103	169	10	plasticity	plasticity	NOUN
dti-2103	169	11	of	of	ADP
dti-2103	169	12	pneumococcus	pneumococcus	NOUN
dti-2103	169	13	and	and	CCONJ
dti-2103	169	14	diverse	diverse	VERB
dti-2103	169	15	nature	nature	NOUN
dti-2103	169	16	of	of	ADP
dti-2103	169	17	cps	cps	PROPN
dti-2103	169	18	loci	loci	PROPN
dti-2103	169	19	,	,	PUNCT
dti-2103	169	20	which	which	PRON
dti-2103	169	21	has	have	AUX
dti-2103	169	22	precluded	preclude	VERB
dti-2103	169	23	the	the	DET
dti-2103	169	24	absolute	absolute	ADJ
dti-2103	169	25	success	success	NOUN
dti-2103	169	26	of	of	ADP
dti-2103	169	27	vaccines	vaccine	NOUN
dti-2103	169	28	(	(	PUNCT
dti-2103	169	29	11,12,32	11,12,32	NUM
dti-2103	169	30	)	)	PUNCT
dti-2103	169	31	.	.	PUNCT
dti-2103	170	1	evidently	evidently	ADV
dti-2103	170	2	,	,	PUNCT
dti-2103	170	3	various	various	ADJ
dti-2103	170	4	virulence	virulence	NOUN
dti-2103	170	5	factors	factor	NOUN
dti-2103	170	6	of	of	ADP
dti-2103	170	7	pneumococci	pneumococci	NOUN
dti-2103	170	8	had	have	AUX
dti-2103	170	9	been	be	AUX
dti-2103	170	10	explored	explore	VERB
dti-2103	170	11	to	to	PART
dti-2103	170	12	understand	understand	VERB
dti-2103	170	13	its	its	PRON
dti-2103	170	14	pathobiology	pathobiology	NOUN
dti-2103	170	15	and	and	CCONJ
dti-2103	170	16	with	with	ADP
dti-2103	170	17	broader	broad	ADJ
dti-2103	170	18	ugpase	ugpase	NOUN
dti-2103	170	19	-	-	PUNCT
dti-2103	170	20	mediated	mediate	VERB
dti-2103	170	21	streptococcus	streptococcus	NOUN
dti-2103	170	22	pneumoniae	pneumoniae	ADJ
dti-2103	170	23	virulence32	virulence32	NOUN
dti-2103	171	1	©	©	ADP
dti-2103	171	2	2020	2020	NUM
dti-2103	172	1	the	the	DET
dti-2103	172	2	authors	author	NOUN
dti-2103	172	3	.	.	PUNCT
dti-2103	173	1	published	publish	VERB
dti-2103	173	2	by	by	ADP
dti-2103	173	3	aboutscience	aboutscience	NOUN
dti-2103	173	4	prospect	prospect	NOUN
dti-2103	173	5	to	to	PART
dti-2103	173	6	yield	yield	VERB
dti-2103	173	7	potential	potential	ADJ
dti-2103	173	8	targets	target	NOUN
dti-2103	173	9	for	for	ADP
dti-2103	173	10	preventive	preventive	ADJ
dti-2103	173	11	interventions	intervention	NOUN
dti-2103	173	12	(	(	PUNCT
dti-2103	173	13	8	8	NUM
dti-2103	173	14	-	-	NUM
dti-2103	173	15	11,21	11,21	NUM
dti-2103	173	16	)	)	PUNCT
dti-2103	173	17	.	.	PUNCT
dti-2103	174	1	elucidation	elucidation	NOUN
dti-2103	174	2	of	of	ADP
dti-2103	174	3	cps	cps	PROPN
dti-2103	174	4	loci	loci	PROPN
dti-2103	174	5	from	from	ADP
dti-2103	174	6	different	different	ADJ
dti-2103	174	7	pneumococcal	pneumococcal	ADJ
dti-2103	174	8	serotypes	serotype	NOUN
dti-2103	174	9	has	have	AUX
dti-2103	174	10	established	establish	VERB
dti-2103	174	11	a	a	DET
dti-2103	174	12	crucial	crucial	ADJ
dti-2103	174	13	role	role	NOUN
dti-2103	174	14	of	of	ADP
dti-2103	174	15	galu	galu	NOUN
dti-2103	174	16	-	-	PUNCT
dti-2103	174	17	encoded	encode	VERB
dti-2103	174	18	ugpase	ugpase	NOUN
dti-2103	174	19	in	in	ADP
dti-2103	174	20	capsule	capsule	ADJ
dti-2103	174	21	formation	formation	NOUN
dti-2103	174	22	(	(	PUNCT
dti-2103	174	23	14,17,18	14,17,18	NUM
dti-2103	174	24	)	)	PUNCT
dti-2103	174	25	.	.	PUNCT
dti-2103	175	1	ugpase	ugpase	NOUN
dti-2103	175	2	-	-	PUNCT
dti-2103	175	3	catalyzed	catalyze	VERB
dti-2103	175	4	reaction	reaction	NOUN
dti-2103	175	5	provides	provide	VERB
dti-2103	175	6	udp	udp	NOUN
dti-2103	175	7	-	-	NOUN
dti-2103	175	8	glucose	glucose	NOUN
dti-2103	175	9	(	(	PUNCT
dti-2103	175	10	glc	glc	PROPN
dti-2103	175	11	)	)	PUNCT
dti-2103	175	12	,	,	PUNCT
dti-2103	175	13	a	a	DET
dti-2103	175	14	key	key	ADJ
dti-2103	175	15	sugar	sugar	NOUN
dti-2103	175	16	precursor	precursor	NOUN
dti-2103	175	17	to	to	PART
dti-2103	175	18	fulfill	fulfill	VERB
dti-2103	175	19	various	various	ADJ
dti-2103	175	20	capsular	capsular	NOUN
dti-2103	175	21	(	(	PUNCT
dti-2103	175	22	cps	cp	NOUN
dti-2103	175	23	biosynthesis	biosynthesis	NOUN
dti-2103	175	24	pathway	pathway	NOUN
dti-2103	175	25	)	)	PUNCT
dti-2103	175	26	and	and	CCONJ
dti-2103	175	27	metabolic	metabolic	NOUN
dti-2103	175	28	(	(	PUNCT
dti-2103	175	29	leloir	leloir	PROPN
dti-2103	175	30	pathway	pathway	NOUN
dti-2103	175	31	)	)	PUNCT
dti-2103	175	32	needs	need	NOUN
dti-2103	175	33	of	of	ADP
dti-2103	175	34	pneumococcus	pneumococcus	NOUN
dti-2103	175	35	(	(	PUNCT
dti-2103	175	36	1214,18,20,36	1214,18,20,36	NUM
dti-2103	175	37	-	-	SYM
dti-2103	175	38	38	38	NUM
dti-2103	175	39	)	)	PUNCT
dti-2103	175	40	.	.	PUNCT
dti-2103	176	1	in	in	ADP
dti-2103	176	2	this	this	DET
dti-2103	176	3	study	study	NOUN
dti-2103	176	4	,	,	PUNCT
dti-2103	176	5	we	we	PRON
dti-2103	176	6	explored	explore	VERB
dti-2103	176	7	the	the	DET
dti-2103	176	8	potential	potential	NOUN
dti-2103	176	9	of	of	ADP
dti-2103	176	10	ugpase	ugpase	NOUN
dti-2103	176	11	in	in	ADP
dti-2103	176	12	modulating	modulate	VERB
dti-2103	176	13	s.	s.	PROPN
dti-2103	176	14	pneumoniae	pneumoniae	ADJ
dti-2103	176	15	pathogenicity	pathogenicity	NOUN
dti-2103	176	16	by	by	ADP
dti-2103	176	17	using	use	VERB
dti-2103	176	18	udp	udp	NOUN
dti-2103	176	19	as	as	ADP
dti-2103	176	20	an	an	DET
dti-2103	176	21	ugpase	ugpase	NOUN
dti-2103	176	22	inhibitor	inhibitor	NOUN
dti-2103	176	23	.	.	PUNCT
dti-2103	177	1	udp	udp	PROPN
dti-2103	177	2	proved	prove	VERB
dti-2103	177	3	to	to	PART
dti-2103	177	4	be	be	AUX
dti-2103	177	5	an	an	DET
dti-2103	177	6	effective	effective	ADJ
dti-2103	177	7	inhibitor	inhibitor	NOUN
dti-2103	177	8	of	of	ADP
dti-2103	177	9	pneumococcal	pneumococcal	ADJ
dti-2103	177	10	ugpase	ugpase	NOUN
dti-2103	177	11	and	and	CCONJ
dti-2103	177	12	mediated	mediate	VERB
dti-2103	177	13	a	a	DET
dti-2103	177	14	significant	significant	ADJ
dti-2103	177	15	reduction	reduction	NOUN
dti-2103	177	16	in	in	ADP
dti-2103	177	17	the	the	DET
dti-2103	177	18	in	in	X
dti-2103	177	19	vitro	vitro	X
dti-2103	177	20	virulence	virulence	NOUN
dti-2103	177	21	of	of	ADP
dti-2103	177	22	pneumococci	pneumococci	NOUN
dti-2103	177	23	.	.	PUNCT
dti-2103	178	1	the	the	DET
dti-2103	178	2	differential	differential	ADJ
dti-2103	178	3	concentration	concentration	NOUN
dti-2103	178	4	-	-	PUNCT
dti-2103	178	5	based	base	VERB
dti-2103	178	6	enzyme	enzyme	NOUN
dti-2103	178	7	activity	activity	NOUN
dti-2103	178	8	inhibition	inhibition	NOUN
dti-2103	178	9	maxima	maxima	NOUN
dti-2103	178	10	suggests	suggest	VERB
dti-2103	178	11	the	the	DET
dti-2103	178	12	feasibility	feasibility	NOUN
dti-2103	178	13	of	of	ADP
dti-2103	178	14	selective	selective	ADJ
dti-2103	178	15	inhibition	inhibition	NOUN
dti-2103	178	16	of	of	ADP
dti-2103	178	17	pneumococcal	pneumococcal	ADJ
dti-2103	178	18	ugpase	ugpase	NOUN
dti-2103	178	19	(	(	PUNCT
dti-2103	178	20	5	5	NUM
dti-2103	178	21	μm	μm	NOUN
dti-2103	178	22	udp	udp	NOUN
dti-2103	178	23	)	)	PUNCT
dti-2103	178	24	without	without	ADP
dti-2103	178	25	inimical	inimical	ADJ
dti-2103	178	26	effect	effect	NOUN
dti-2103	178	27	on	on	ADP
dti-2103	178	28	host	host	NOUN
dti-2103	178	29	.	.	PUNCT
dti-2103	179	1	the	the	DET
dti-2103	179	2	decline	decline	NOUN
dti-2103	179	3	in	in	ADP
dti-2103	179	4	pneumococcal	pneumococcal	ADJ
dti-2103	179	5	adherence	adherence	NOUN
dti-2103	179	6	to	to	ADP
dti-2103	179	7	host	host	NOUN
dti-2103	179	8	cell	cell	NOUN
dti-2103	179	9	lines	line	NOUN
dti-2103	179	10	also	also	ADV
dti-2103	179	11	accentuates	accentuate	VERB
dti-2103	179	12	the	the	DET
dti-2103	179	13	efficacy	efficacy	NOUN
dti-2103	179	14	of	of	ADP
dti-2103	179	15	udp	udp	PROPN
dti-2103	179	16	as	as	ADP
dti-2103	179	17	an	an	DET
dti-2103	179	18	inhibitor	inhibitor	NOUN
dti-2103	179	19	.	.	PUNCT
dti-2103	180	1	a	a	DET
dti-2103	180	2	study	study	NOUN
dti-2103	180	3	by	by	ADP
dti-2103	180	4	zavala	zavala	PROPN
dti-2103	180	5	et	et	PROPN
dti-2103	180	6	al	al	PROPN
dti-2103	180	7	used	use	VERB
dti-2103	180	8	nucleoside	nucleoside	NOUN
dti-2103	180	9	analogs	analog	NOUN
dti-2103	180	10	,	,	PUNCT
dti-2103	180	11	namely	namely	ADV
dti-2103	180	12	abacavir	abacavir	PROPN
dti-2103	180	13	,	,	PUNCT
dti-2103	180	14	decitabine	decitabine	NOUN
dti-2103	180	15	,	,	PUNCT
dti-2103	180	16	stavudine	stavudine	ADJ
dti-2103	180	17	,	,	PUNCT
dti-2103	180	18	and	and	CCONJ
dti-2103	180	19	zidovudine	zidovudine	NOUN
dti-2103	180	20	,	,	PUNCT
dti-2103	180	21	to	to	PART
dti-2103	180	22	show	show	VERB
dti-2103	180	23	42%-58	42%-58	NUM
dti-2103	180	24	%	%	NOUN
dti-2103	180	25	inhibition	inhibition	NOUN
dti-2103	180	26	of	of	ADP
dti-2103	180	27	ugpase	ugpase	NOUN
dti-2103	180	28	,	,	PUNCT
dti-2103	180	29	but	but	CCONJ
dti-2103	180	30	did	do	AUX
dti-2103	180	31	not	not	PART
dti-2103	180	32	elaborate	elaborate	VERB
dti-2103	180	33	on	on	ADP
dti-2103	180	34	the	the	DET
dti-2103	180	35	use	use	NOUN
dti-2103	180	36	of	of	ADP
dti-2103	180	37	high	high	ADJ
dti-2103	180	38	concentration	concentration	NOUN
dti-2103	180	39	(	(	PUNCT
dti-2103	180	40	7.5	7.5	NUM
dti-2103	180	41	mm	mm	NOUN
dti-2103	180	42	)	)	PUNCT
dti-2103	180	43	of	of	ADP
dti-2103	180	44	inhibitors	inhibitor	NOUN
dti-2103	180	45	,	,	PUNCT
dti-2103	180	46	their	their	PRON
dti-2103	180	47	toxic	toxic	ADJ
dti-2103	180	48	effects	effect	NOUN
dti-2103	180	49	,	,	PUNCT
dti-2103	180	50	and	and	CCONJ
dti-2103	180	51	safety	safety	NOUN
dti-2103	180	52	as	as	ADP
dti-2103	180	53	antipneumococcal	antipneumococcal	ADJ
dti-2103	180	54	drug	drug	NOUN
dti-2103	180	55	(	(	PUNCT
dti-2103	180	56	23	23	NUM
dti-2103	180	57	)	)	PUNCT
dti-2103	180	58	.	.	PUNCT
dti-2103	181	1	our	our	PRON
dti-2103	181	2	study	study	NOUN
dti-2103	181	3	establishes	establish	VERB
dti-2103	181	4	the	the	DET
dti-2103	181	5	noncytotoxicity	noncytotoxicity	NOUN
dti-2103	181	6	of	of	ADP
dti-2103	181	7	udp	udp	NOUN
dti-2103	181	8	to	to	PART
dti-2103	181	9	host	host	NOUN
dti-2103	181	10	cells	cell	NOUN
dti-2103	181	11	and	and	CCONJ
dti-2103	181	12	boosted	boost	VERB
dti-2103	181	13	uptake	uptake	NOUN
dti-2103	181	14	of	of	ADP
dti-2103	181	15	s.	s.	PROPN
dti-2103	181	16	pneumoniae	pneumoniae	ADJ
dti-2103	181	17	upon	upon	SCONJ
dti-2103	181	18	udp	udp	NOUN
dti-2103	181	19	stimulation	stimulation	NOUN
dti-2103	181	20	by	by	ADP
dti-2103	181	21	macrophage	macrophage	ADJ
dti-2103	181	22	cell	cell	NOUN
dti-2103	181	23	lines	line	NOUN
dti-2103	181	24	.	.	PUNCT
dti-2103	182	1	our	our	PRON
dti-2103	182	2	findings	finding	NOUN
dti-2103	182	3	are	be	AUX
dti-2103	182	4	supported	support	VERB
dti-2103	182	5	by	by	ADP
dti-2103	182	6	previous	previous	ADJ
dti-2103	182	7	studies	study	NOUN
dti-2103	182	8	on	on	ADP
dti-2103	182	9	the	the	DET
dti-2103	182	10	clearance	clearance	NOUN
dti-2103	182	11	of	of	ADP
dti-2103	182	12	escherichia	escherichia	NOUN
dti-2103	182	13	coli	coli	NOUN
dti-2103	182	14	from	from	ADP
dti-2103	182	15	peritonitis	peritonitis	NOUN
dti-2103	182	16	mouse	mouse	NOUN
dti-2103	182	17	model	model	NOUN
dti-2103	182	18	in	in	ADP
dti-2103	182	19	response	response	NOUN
dti-2103	182	20	to	to	ADP
dti-2103	182	21	direct	direct	ADJ
dti-2103	182	22	udp	udp	NOUN
dti-2103	182	23	injection	injection	NOUN
dti-2103	182	24	(	(	PUNCT
dti-2103	182	25	33	33	NUM
dti-2103	182	26	)	)	PUNCT
dti-2103	182	27	and	and	CCONJ
dti-2103	182	28	increased	increase	VERB
dti-2103	182	29	host	host	NOUN
dti-2103	182	30	defenses	defense	NOUN
dti-2103	182	31	upon	upon	SCONJ
dti-2103	182	32	udp	udp	NOUN
dti-2103	182	33	binding	bind	VERB
dti-2103	182	34	to	to	ADP
dti-2103	182	35	p2y6	p2y6	NOUN
dti-2103	182	36	receptor	receptor	NOUN
dti-2103	182	37	(	(	PUNCT
dti-2103	182	38	34	34	NUM
dti-2103	182	39	-	-	SYM
dti-2103	182	40	36	36	NUM
dti-2103	182	41	)	)	PUNCT
dti-2103	182	42	.	.	PUNCT
dti-2103	183	1	the	the	DET
dti-2103	183	2	crucial	crucial	ADJ
dti-2103	183	3	role	role	NOUN
dti-2103	183	4	of	of	ADP
dti-2103	183	5	udp	udp	NOUN
dti-2103	183	6	as	as	ADP
dti-2103	183	7	inflammatory	inflammatory	ADJ
dti-2103	183	8	inducer	inducer	NOUN
dti-2103	183	9	in	in	ADP
dti-2103	183	10	brain	brain	NOUN
dti-2103	183	11	injuries	injury	NOUN
dti-2103	183	12	has	have	AUX
dti-2103	183	13	been	be	AUX
dti-2103	183	14	reported	report	VERB
dti-2103	183	15	in	in	ADP
dti-2103	183	16	microglia	microglia	NOUN
dti-2103	183	17	and	and	CCONJ
dti-2103	183	18	astrocytes	astrocyte	NOUN
dti-2103	183	19	(	(	PUNCT
dti-2103	183	20	28	28	NUM
dti-2103	183	21	)	)	PUNCT
dti-2103	183	22	.	.	PUNCT
dti-2103	184	1	likewise	likewise	ADV
dti-2103	184	2	,	,	PUNCT
dti-2103	184	3	we	we	PRON
dti-2103	184	4	have	have	AUX
dti-2103	184	5	also	also	ADV
dti-2103	184	6	found	find	VERB
dti-2103	184	7	the	the	DET
dti-2103	184	8	activation	activation	NOUN
dti-2103	184	9	of	of	ADP
dti-2103	184	10	proinflammatory	proinflammatory	ADJ
dti-2103	184	11	cytokines	cytokine	NOUN
dti-2103	184	12	in	in	ADP
dti-2103	184	13	alveolar	alveolar	ADJ
dti-2103	184	14	epithelial	epithelial	ADJ
dti-2103	184	15	cells	cell	NOUN
dti-2103	184	16	in	in	ADP
dti-2103	184	17	response	response	NOUN
dti-2103	184	18	to	to	ADP
dti-2103	184	19	pneumococcal	pneumococcal	ADJ
dti-2103	184	20	infection	infection	NOUN
dti-2103	184	21	.	.	PUNCT
dti-2103	185	1	the	the	DET
dti-2103	185	2	stimulation	stimulation	NOUN
dti-2103	185	3	of	of	ADP
dti-2103	185	4	cytokines	cytokine	NOUN
dti-2103	185	5	by	by	ADP
dti-2103	185	6	udp	udp	NOUN
dti-2103	185	7	emphasizes	emphasize	VERB
dti-2103	185	8	its	its	PRON
dti-2103	185	9	protective	protective	ADJ
dti-2103	185	10	functional	functional	ADJ
dti-2103	185	11	nature	nature	NOUN
dti-2103	185	12	,	,	PUNCT
dti-2103	185	13	which	which	PRON
dti-2103	185	14	might	might	AUX
dti-2103	185	15	enhance	enhance	VERB
dti-2103	185	16	its	its	PRON
dti-2103	185	17	efficacy	efficacy	NOUN
dti-2103	185	18	as	as	ADP
dti-2103	185	19	a	a	DET
dti-2103	185	20	potent	potent	ADJ
dti-2103	185	21	inhibitor	inhibitor	NOUN
dti-2103	185	22	.	.	PUNCT
dti-2103	186	1	the	the	DET
dti-2103	186	2	present	present	ADJ
dti-2103	186	3	study	study	NOUN
dti-2103	186	4	provides	provide	VERB
dti-2103	186	5	evidence	evidence	NOUN
dti-2103	186	6	to	to	ADP
dti-2103	186	7	the	the	DET
dti-2103	186	8	udp	udp	NOUN
dti-2103	186	9	-	-	ADJ
dti-2103	186	10	mediated	mediate	VERB
dti-2103	186	11	reduction	reduction	NOUN
dti-2103	186	12	in	in	ADP
dti-2103	186	13	the	the	DET
dti-2103	186	14	virulence	virulence	NOUN
dti-2103	186	15	of	of	ADP
dti-2103	186	16	s.	s.	PROPN
dti-2103	186	17	pneumoniae	pneumoniae	PROPN
dti-2103	186	18	.	.	PUNCT
dti-2103	187	1	being	be	AUX
dti-2103	187	2	one	one	NUM
dti-2103	187	3	of	of	ADP
dti-2103	187	4	the	the	DET
dti-2103	187	5	intercellular	intercellular	ADJ
dti-2103	187	6	messengers	messenger	NOUN
dti-2103	187	7	,	,	PUNCT
dti-2103	187	8	udp	udp	NOUN
dti-2103	187	9	acts	act	VERB
dti-2103	187	10	as	as	ADP
dti-2103	187	11	a	a	DET
dti-2103	187	12	protective	protective	ADJ
dti-2103	187	13	signaling	signal	VERB
dti-2103	187	14	molecule	molecule	NOUN
dti-2103	187	15	and	and	CCONJ
dti-2103	187	16	activates	activate	VERB
dti-2103	187	17	p2y6	p2y6	NOUN
dti-2103	187	18	receptors	receptor	NOUN
dti-2103	187	19	that	that	PRON
dti-2103	187	20	are	be	AUX
dti-2103	187	21	known	know	VERB
dti-2103	187	22	to	to	PART
dti-2103	187	23	result	result	VERB
dti-2103	187	24	in	in	ADP
dti-2103	187	25	wide	wide	ADJ
dti-2103	187	26	range	range	NOUN
dti-2103	187	27	of	of	ADP
dti-2103	187	28	physiologic	physiologic	ADJ
dti-2103	187	29	responses	response	NOUN
dti-2103	187	30	,	,	PUNCT
dti-2103	187	31	such	such	ADJ
dti-2103	187	32	as	as	ADP
dti-2103	187	33	induction	induction	NOUN
dti-2103	187	34	of	of	ADP
dti-2103	187	35	cytokines	cytokine	NOUN
dti-2103	187	36	,	,	PUNCT
dti-2103	187	37	chemokines	chemokine	NOUN
dti-2103	187	38	,	,	PUNCT
dti-2103	187	39	phagocytosis	phagocytosis	NOUN
dti-2103	187	40	,	,	PUNCT
dti-2103	187	41	and	and	CCONJ
dti-2103	187	42	increase	increase	VERB
dti-2103	187	43	in	in	ADP
dti-2103	187	44	concentration	concentration	NOUN
dti-2103	187	45	of	of	ADP
dti-2103	187	46	extracellular	extracellular	ADJ
dti-2103	187	47	nucleotides	nucleotide	NOUN
dti-2103	187	48	(	(	PUNCT
dti-2103	187	49	33,35,37,38	33,35,37,38	NUM
dti-2103	187	50	)	)	PUNCT
dti-2103	187	51	.	.	PUNCT
dti-2103	188	1	the	the	DET
dti-2103	188	2	evidence	evidence	NOUN
dti-2103	188	3	of	of	ADP
dti-2103	188	4	udp	udp	NOUN
dti-2103	188	5	meddling	meddle	VERB
dti-2103	188	6	with	with	ADP
dti-2103	188	7	host	host	NOUN
dti-2103	188	8	-	-	PUNCT
dti-2103	188	9	pathogen	pathogen	NOUN
dti-2103	188	10	interactions	interaction	NOUN
dti-2103	188	11	has	have	AUX
dti-2103	188	12	opened	open	VERB
dti-2103	188	13	the	the	DET
dti-2103	188	14	vast	vast	ADJ
dti-2103	188	15	horizon	horizon	NOUN
dti-2103	188	16	to	to	PART
dti-2103	188	17	investigate	investigate	VERB
dti-2103	188	18	its	its	PRON
dti-2103	188	19	underlying	underlie	VERB
dti-2103	188	20	mechanisms	mechanism	NOUN
dti-2103	188	21	,	,	PUNCT
dti-2103	188	22	which	which	PRON
dti-2103	188	23	would	would	AUX
dti-2103	188	24	definitely	definitely	ADV
dti-2103	188	25	shed	shed	VERB
dti-2103	188	26	light	light	NOUN
dti-2103	188	27	on	on	ADP
dti-2103	188	28	its	its	PRON
dti-2103	188	29	potential	potential	ADJ
dti-2103	188	30	utility	utility	NOUN
dti-2103	188	31	in	in	ADP
dti-2103	188	32	restraining	restrain	VERB
dti-2103	188	33	the	the	DET
dti-2103	188	34	pneumococcal	pneumococcal	ADJ
dti-2103	188	35	virulence	virulence	NOUN
dti-2103	188	36	.	.	PUNCT
dti-2103	189	1	the	the	DET
dti-2103	189	2	present	present	ADJ
dti-2103	189	3	work	work	NOUN
dti-2103	189	4	is	be	AUX
dti-2103	189	5	a	a	DET
dti-2103	189	6	little	little	ADJ
dti-2103	189	7	step	step	NOUN
dti-2103	189	8	forward	forward	ADV
dti-2103	189	9	in	in	ADP
dti-2103	189	10	search	search	NOUN
dti-2103	189	11	of	of	ADP
dti-2103	189	12	potential	potential	ADJ
dti-2103	189	13	s.	s.	PROPN
dti-2103	189	14	pneumoniae	pneumoniae	ADJ
dti-2103	189	15	inhibitor	inhibitor	NOUN
dti-2103	189	16	independent	independent	ADJ
dti-2103	189	17	of	of	ADP
dti-2103	189	18	serotypes	serotype	NOUN
dti-2103	189	19	,	,	PUNCT
dti-2103	189	20	though	though	SCONJ
dti-2103	189	21	the	the	DET
dti-2103	189	22	inhibitory	inhibitory	ADJ
dti-2103	189	23	effect	effect	NOUN
dti-2103	189	24	of	of	ADP
dti-2103	189	25	udp	udp	NOUN
dti-2103	189	26	should	should	AUX
dti-2103	189	27	be	be	AUX
dti-2103	189	28	evaluated	evaluate	VERB
dti-2103	189	29	in	in	ADP
dti-2103	189	30	vivo	vivo	NOUN
dti-2103	189	31	to	to	PART
dti-2103	189	32	ascertain	ascertain	VERB
dti-2103	189	33	its	its	PRON
dti-2103	189	34	efficacy	efficacy	NOUN
dti-2103	189	35	.	.	PUNCT
dti-2103	190	1	our	our	PRON
dti-2103	190	2	study	study	NOUN
dti-2103	190	3	has	have	AUX
dti-2103	190	4	been	be	AUX
dti-2103	190	5	limited	limit	VERB
dti-2103	190	6	in	in	ADP
dti-2103	190	7	evaluating	evaluate	VERB
dti-2103	190	8	the	the	DET
dti-2103	190	9	cytokine	cytokine	ADJ
dti-2103	190	10	response	response	NOUN
dti-2103	190	11	and	and	CCONJ
dti-2103	190	12	udp	udp	NOUN
dti-2103	190	13	-	-	ADJ
dti-2103	190	14	mediated	mediate	VERB
dti-2103	190	15	behavior	behavior	NOUN
dti-2103	190	16	of	of	ADP
dti-2103	190	17	p2y6	p2y6	NOUN
dti-2103	190	18	receptors	receptor	NOUN
dti-2103	190	19	,	,	PUNCT
dti-2103	190	20	which	which	PRON
dti-2103	190	21	further	far	ADV
dti-2103	190	22	need	need	VERB
dti-2103	190	23	a	a	DET
dti-2103	190	24	detailed	detailed	ADJ
dti-2103	190	25	investigation	investigation	NOUN
dti-2103	190	26	.	.	PUNCT
dti-2103	191	1	mechanistic	mechanistic	ADJ
dti-2103	191	2	understanding	understanding	NOUN
dti-2103	191	3	of	of	ADP
dti-2103	191	4	udpmediated	udpmediated	ADJ
dti-2103	191	5	ugpase	ugpase	NOUN
dti-2103	191	6	inhibition	inhibition	NOUN
dti-2103	191	7	and	and	CCONJ
dti-2103	191	8	its	its	PRON
dti-2103	191	9	in	in	ADP
dti-2103	191	10	vivo	vivo	ADJ
dti-2103	191	11	validation	validation	NOUN
dti-2103	191	12	would	would	AUX
dti-2103	191	13	be	be	AUX
dti-2103	191	14	crucial	crucial	ADJ
dti-2103	191	15	for	for	ADP
dti-2103	191	16	translating	translate	VERB
dti-2103	191	17	the	the	DET
dti-2103	191	18	outcome	outcome	NOUN
dti-2103	191	19	of	of	ADP
dti-2103	191	20	this	this	DET
dti-2103	191	21	study	study	NOUN
dti-2103	191	22	.	.	PUNCT
dti-2103	192	1	author	author	NOUN
dti-2103	192	2	contributions	contribution	NOUN
dti-2103	192	3	monica	monica	PROPN
dti-2103	192	4	sharma	sharma	PROPN
dti-2103	192	5	performed	perform	VERB
dti-2103	192	6	the	the	DET
dti-2103	192	7	experiments	experiment	NOUN
dti-2103	192	8	,	,	PUNCT
dti-2103	192	9	analyzed	analyze	VERB
dti-2103	192	10	the	the	DET
dti-2103	192	11	data	datum	NOUN
dti-2103	192	12	,	,	PUNCT
dti-2103	192	13	and	and	CCONJ
dti-2103	192	14	wrote	write	VERB
dti-2103	192	15	the	the	DET
dti-2103	192	16	manuscript	manuscript	NOUN
dti-2103	192	17	.	.	PUNCT
dti-2103	193	1	swati	swati	PROPN
dti-2103	193	2	sharma	sharma	PROPN
dti-2103	193	3	helped	help	VERB
dti-2103	193	4	in	in	ADP
dti-2103	193	5	manuscript	manuscript	NOUN
dti-2103	193	6	editing	edit	VERB
dti-2103	193	7	.	.	PUNCT
dti-2103	194	1	anuradha	anuradha	PROPN
dti-2103	194	2	chakraborti	chakraborti	PROPN
dti-2103	194	3	and	and	CCONJ
dti-2103	194	4	monica	monica	PROPN
dti-2103	194	5	sharma	sharma	PROPN
dti-2103	194	6	designed	design	VERB
dti-2103	194	7	the	the	DET
dti-2103	194	8	study	study	NOUN
dti-2103	194	9	.	.	PUNCT
dti-2103	195	1	pallab	pallab	PROPN
dti-2103	195	2	ray	ray	NOUN
dti-2103	195	3	provided	provide	VERB
dti-2103	195	4	the	the	DET
dti-2103	195	5	clinical	clinical	ADJ
dti-2103	195	6	isolates	isolate	NOUN
dti-2103	195	7	for	for	ADP
dti-2103	195	8	the	the	DET
dti-2103	195	9	study	study	NOUN
dti-2103	195	10	.	.	PUNCT
dti-2103	196	1	anuradha	anuradha	PROPN
dti-2103	196	2	chakraborti	chakraborti	PROPN
dti-2103	196	3	and	and	CCONJ
dti-2103	196	4	pallab	pallab	PROPN
dti-2103	196	5	ray	ray	NOUN
dti-2103	196	6	reviewed	review	VERB
dti-2103	196	7	the	the	DET
dti-2103	196	8	study	study	NOUN
dti-2103	196	9	and	and	CCONJ
dti-2103	196	10	manuscript	manuscript	NOUN
dti-2103	196	11	.	.	PUNCT
dti-2103	197	1	disclosures	disclosure	VERB
dti-2103	197	2	financial	financial	ADJ
dti-2103	197	3	support	support	NOUN
dti-2103	197	4	:	:	PUNCT
dti-2103	197	5	the	the	DET
dti-2103	197	6	authors	author	NOUN
dti-2103	197	7	are	be	AUX
dti-2103	197	8	grateful	grateful	ADJ
dti-2103	197	9	to	to	ADP
dti-2103	197	10	the	the	DET
dti-2103	197	11	indian	indian	ADJ
dti-2103	197	12	council	council	PROPN
dti-2103	197	13	of	of	ADP
dti-2103	197	14	medical	medical	ADJ
dti-2103	197	15	research	research	NOUN
dti-2103	197	16	(	(	PUNCT
dti-2103	197	17	icmr	icmr	PROPN
dti-2103	197	18	)	)	PUNCT
dti-2103	197	19	,	,	PUNCT
dti-2103	197	20	new	new	PROPN
dti-2103	197	21	delhi	delhi	PROPN
dti-2103	197	22	,	,	PUNCT
dti-2103	197	23	india	india	PROPN
dti-2103	197	24	for	for	ADP
dti-2103	197	25	financial	financial	ADJ
dti-2103	197	26	support	support	NOUN
dti-2103	197	27	and	and	CCONJ
dti-2103	197	28	providing	provide	VERB
dti-2103	197	29	senior	senior	ADJ
dti-2103	197	30	research	research	NOUN
dti-2103	197	31	fellowship	fellowship	NOUN
dti-2103	197	32	(	(	PUNCT
dti-2103	197	33	file	file	VERB
dti-2103	197	34	no	no	NOUN
dti-2103	197	35	.	.	PUNCT
dti-2103	198	1	80/768/2012	80/768/2012	NUM
dti-2103	198	2	-	-	PUNCT
dti-2103	198	3	ecd-1	ecd-1	NOUN
dti-2103	198	4	)	)	PUNCT
dti-2103	198	5	to	to	ADP
dti-2103	198	6	ms	ms	PROPN
dti-2103	198	7	.	.	PROPN
dti-2103	198	8	monica	monica	PROPN
dti-2103	198	9	sharma	sharma	PROPN
dti-2103	198	10	and	and	CCONJ
dti-2103	198	11	funding	fund	VERB
dti-2103	198	12	the	the	DET
dti-2103	198	13	project	project	NOUN
dti-2103	198	14	.	.	PUNCT
dti-2103	199	1	swati	swati	PROPN
dti-2103	199	2	sharma	sharma	PROPN
dti-2103	199	3	received	receive	VERB
dti-2103	199	4	research	research	NOUN
dti-2103	199	5	fellowship	fellowship	NOUN
dti-2103	199	6	from	from	ADP
dti-2103	199	7	council	council	NOUN
dti-2103	199	8	of	of	ADP
dti-2103	199	9	scientific	scientific	ADJ
dti-2103	199	10	and	and	CCONJ
dti-2103	199	11	industrial	industrial	ADJ
dti-2103	199	12	research	research	NOUN
dti-2103	199	13	(	(	PUNCT
dti-2103	199	14	csir	csir	PROPN
dti-2103	199	15	)	)	PUNCT
dti-2103	199	16	new	new	PROPN
dti-2103	199	17	delhi	delhi	PROPN
dti-2103	199	18	,	,	PUNCT
dti-2103	199	19	india	india	PROPN
dti-2103	199	20	.	.	PUNCT
dti-2103	200	1	authors	author	NOUN
dti-2103	200	2	disclose	disclose	VERB
dti-2103	200	3	no	no	DET
dti-2103	200	4	other	other	ADJ
dti-2103	200	5	external	external	ADJ
dti-2103	200	6	funding	funding	NOUN
dti-2103	200	7	sources	source	NOUN
dti-2103	200	8	.	.	PUNCT
dti-2103	201	1	conflict	conflict	NOUN
dti-2103	201	2	of	of	ADP
dti-2103	201	3	interest	interest	NOUN
dti-2103	201	4	:	:	PUNCT
dti-2103	201	5	the	the	DET
dti-2103	201	6	authors	author	NOUN
dti-2103	201	7	declare	declare	VERB
dti-2103	201	8	no	no	DET
dti-2103	201	9	conflict	conflict	NOUN
dti-2103	201	10	of	of	ADP
dti-2103	201	11	interest	interest	NOUN
dti-2103	201	12	.	.	PUNCT
dti-2103	202	1	references	reference	NOUN
dti-2103	202	2	1	1	NUM
dti-2103	202	3	.	.	X
dti-2103	202	4	musher	musher	PROPN
dti-2103	202	5	dm	dm	PROPN
dti-2103	202	6	.	.	PUNCT
dti-2103	202	7	streptococcus	streptococcus	NOUN
dti-2103	202	8	pneumoniae	pneumoniae	ADV
dti-2103	202	9	.	.	PUNCT
dti-2103	203	1	in	in	ADP
dti-2103	203	2	:	:	PUNCT
dti-2103	203	3	mandell	mandell	PROPN
dti-2103	203	4	gl	gl	PROPN
dti-2103	203	5	,	,	PUNCT
dti-2103	203	6	bennett	bennett	PROPN
dti-2103	203	7	je	je	PROPN
dti-2103	203	8	,	,	PUNCT
dti-2103	203	9	dolin	dolin	PROPN
dti-2103	203	10	r	r	PROPN
dti-2103	203	11	,	,	PUNCT
dti-2103	203	12	eds	eds	PROPN
dti-2103	203	13	.	.	PUNCT
dti-2103	204	1	mandell	mandell	PROPN
dti-2103	204	2	,	,	PUNCT
dti-2103	204	3	douglas	douglas	PROPN
dti-2103	204	4	,	,	PUNCT
dti-2103	204	5	and	and	CCONJ
dti-2103	204	6	bennett	bennett	PROPN
dti-2103	204	7	’s	’s	PART
dti-2103	204	8	principles	principle	NOUN
dti-2103	204	9	and	and	CCONJ
dti-2103	204	10	practice	practice	NOUN
dti-2103	204	11	of	of	ADP
dti-2103	204	12	infectious	infectious	ADJ
dti-2103	204	13	diseases	disease	NOUN
dti-2103	204	14	.	.	PUNCT
dti-2103	205	1	7th	7th	ADJ
dti-2103	205	2	ed	ed	NOUN
dti-2103	205	3	.	.	PUNCT
dti-2103	205	4	philadelphia	philadelphia	PROPN
dti-2103	205	5	,	,	PUNCT
dti-2103	205	6	pa	pa	PROPN
dti-2103	205	7	:	:	PUNCT
dti-2103	205	8	churchill	churchill	PROPN
dti-2103	205	9	livingstone	livingstone	PROPN
dti-2103	205	10	elsevier	elsevier	PROPN
dti-2103	205	11	2010	2010	NUM
dti-2103	205	12	;	;	PUNCT
dti-2103	205	13	2623	2623	NUM
dti-2103	205	14	-	-	SYM
dti-2103	205	15	2642	2642	NUM
dti-2103	205	16	.	.	PUNCT
dti-2103	206	1	2	2	X
dti-2103	206	2	.	.	X
dti-2103	206	3	troeger	troeger	PROPN
dti-2103	206	4	c	c	PROPN
dti-2103	206	5	,	,	PUNCT
dti-2103	206	6	blacker	black	ADJ
dti-2103	206	7	b	b	PROPN
dti-2103	206	8	,	,	PUNCT
dti-2103	206	9	khalil	khalil	PROPN
dti-2103	206	10	ia	ia	PROPN
dti-2103	206	11	,	,	PUNCT
dti-2103	206	12	et	et	PROPN
dti-2103	206	13	al	al	PROPN
dti-2103	206	14	.	.	PROPN
dti-2103	206	15	,	,	PUNCT
dti-2103	206	16	srm	srm	PROPN
dti-2103	206	17	gbd	gbd	NOUN
dti-2103	206	18	2016	2016	NUM
dti-2103	206	19	lower	low	ADJ
dti-2103	206	20	respiratory	respiratory	ADJ
dti-2103	206	21	infections	infection	NOUN
dti-2103	206	22	collaborators	collaborator	NOUN
dti-2103	206	23	.	.	PUNCT
dti-2103	207	1	estimates	estimate	NOUN
dti-2103	207	2	of	of	ADP
dti-2103	207	3	the	the	DET
dti-2103	207	4	global	global	ADJ
dti-2103	207	5	,	,	PUNCT
dti-2103	207	6	regional	regional	ADJ
dti-2103	207	7	,	,	PUNCT
dti-2103	207	8	and	and	CCONJ
dti-2103	207	9	national	national	ADJ
dti-2103	207	10	morbidity	morbidity	NOUN
dti-2103	207	11	,	,	PUNCT
dti-2103	207	12	mortality	mortality	NOUN
dti-2103	207	13	,	,	PUNCT
dti-2103	207	14	and	and	CCONJ
dti-2103	207	15	aetiologies	aetiology	NOUN
dti-2103	207	16	of	of	ADP
dti-2103	207	17	lower	low	ADJ
dti-2103	207	18	respiratory	respiratory	ADJ
dti-2103	207	19	infections	infection	NOUN
dti-2103	207	20	in	in	ADP
dti-2103	207	21	195	195	NUM
dti-2103	207	22	countries	country	NOUN
dti-2103	207	23	,	,	PUNCT
dti-2103	207	24	1990	1990	NUM
dti-2103	207	25	-	-	SYM
dti-2103	207	26	2016	2016	NUM
dti-2103	207	27	:	:	PUNCT
dti-2103	207	28	a	a	DET
dti-2103	207	29	systematic	systematic	ADJ
dti-2103	207	30	analysis	analysis	NOUN
dti-2103	207	31	for	for	ADP
dti-2103	207	32	the	the	DET
dti-2103	207	33	global	global	ADJ
dti-2103	207	34	burden	burden	NOUN
dti-2103	207	35	of	of	ADP
dti-2103	207	36	disease	disease	NOUN
dti-2103	207	37	study	study	NOUN
dti-2103	207	38	2016	2016	NUM
dti-2103	207	39	.	.	PUNCT
dti-2103	208	1	lancet	lancet	PROPN
dti-2103	208	2	infect	infect	PROPN
dti-2103	208	3	dis	dis	PROPN
dti-2103	208	4	.	.	PUNCT
dti-2103	209	1	2018;18:1191	2018;18:1191	NUM
dti-2103	209	2	-	-	SYM
dti-2103	209	3	1210	1210	NUM
dti-2103	209	4	.	.	PUNCT
dti-2103	210	1	3	3	X
dti-2103	210	2	.	.	X
dti-2103	210	3	wahl	wahl	PROPN
dti-2103	210	4	b	b	PROPN
dti-2103	210	5	,	,	PUNCT
dti-2103	210	6	o’brien	o’brien	PROPN
dti-2103	210	7	kl	kl	PROPN
dti-2103	210	8	,	,	PUNCT
dti-2103	210	9	greenbaum	greenbaum	PROPN
dti-2103	210	10	a	a	X
dti-2103	210	11	,	,	PUNCT
dti-2103	210	12	et	et	PROPN
dti-2103	210	13	al	al	PROPN
dti-2103	210	14	.	.	PUNCT
dti-2103	210	15	burden	burden	NOUN
dti-2103	210	16	of	of	ADP
dti-2103	210	17	streptococcus	streptococcus	NOUN
dti-2103	210	18	pneumoniae	pneumoniae	ADJ
dti-2103	210	19	and	and	CCONJ
dti-2103	210	20	haemophilus	haemophilus	ADJ
dti-2103	210	21	influenzae	influenzae	VERB
dti-2103	210	22	type	type	NOUN
dti-2103	210	23	b	b	PROPN
dti-2103	210	24	disease	disease	NOUN
dti-2103	210	25	in	in	ADP
dti-2103	210	26	children	child	NOUN
dti-2103	210	27	in	in	ADP
dti-2103	210	28	the	the	DET
dti-2103	210	29	era	era	NOUN
dti-2103	210	30	of	of	ADP
dti-2103	210	31	conjugate	conjugate	ADJ
dti-2103	210	32	vaccines	vaccine	NOUN
dti-2103	210	33	:	:	PUNCT
dti-2103	210	34	global	global	ADJ
dti-2103	210	35	,	,	PUNCT
dti-2103	210	36	regional	regional	ADJ
dti-2103	210	37	,	,	PUNCT
dti-2103	210	38	and	and	CCONJ
dti-2103	210	39	national	national	ADJ
dti-2103	210	40	estimates	estimate	NOUN
dti-2103	210	41	for	for	ADP
dti-2103	210	42	2000	2000	NUM
dti-2103	210	43	-	-	SYM
dti-2103	210	44	15	15	NUM
dti-2103	210	45	.	.	PUNCT
dti-2103	211	1	lancet	lancet	NOUN
dti-2103	211	2	glob	glob	PROPN
dti-2103	211	3	health	health	NOUN
dti-2103	211	4	.	.	PUNCT
dti-2103	212	1	2018;6	2018;6	NOUN
dti-2103	212	2	:	:	PUNCT
dti-2103	212	3	e744	e744	PROPN
dti-2103	212	4	-	-	PUNCT
dti-2103	212	5	e757	e757	PROPN
dti-2103	212	6	.	.	NOUN
dti-2103	213	1	4	4	NUM
dti-2103	213	2	.	.	X
dti-2103	213	3	wahl	wahl	PROPN
dti-2103	213	4	b	b	PROPN
dti-2103	213	5	,	,	PUNCT
dti-2103	213	6	sharan	sharan	NOUN
dti-2103	213	7	a	a	PRON
dti-2103	213	8	,	,	PUNCT
dti-2103	213	9	deloria	deloria	PROPN
dti-2103	213	10	knoll	knoll	PROPN
dti-2103	213	11	m	m	PROPN
dti-2103	213	12	,	,	PUNCT
dti-2103	213	13	et	et	PROPN
dti-2103	213	14	al	al	PROPN
dti-2103	213	15	.	.	PROPN
dti-2103	213	16	national	national	ADJ
dti-2103	213	17	,	,	PUNCT
dti-2103	213	18	regional	regional	ADJ
dti-2103	213	19	,	,	PUNCT
dti-2103	213	20	and	and	CCONJ
dti-2103	213	21	state	state	NOUN
dti-2103	213	22	-	-	PUNCT
dti-2103	213	23	level	level	NOUN
dti-2103	213	24	burden	burden	NOUN
dti-2103	213	25	of	of	ADP
dti-2103	213	26	streptococcus	streptococcus	NOUN
dti-2103	213	27	pneumoniae	pneumoniae	ADJ
dti-2103	213	28	and	and	CCONJ
dti-2103	213	29	haemophilus	haemophilus	ADJ
dti-2103	213	30	influenzae	influenzae	VERB
dti-2103	213	31	type	type	NOUN
dti-2103	213	32	b	b	PROPN
dti-2103	213	33	disease	disease	NOUN
dti-2103	213	34	in	in	ADP
dti-2103	213	35	children	child	NOUN
dti-2103	213	36	in	in	ADP
dti-2103	213	37	india	india	PROPN
dti-2103	213	38	:	:	PUNCT
dti-2103	213	39	modeled	model	VERB
dti-2103	213	40	estimates	estimate	NOUN
dti-2103	213	41	for	for	ADP
dti-2103	213	42	2000	2000	NUM
dti-2103	213	43	-	-	SYM
dti-2103	213	44	15	15	NUM
dti-2103	213	45	.	.	PUNCT
dti-2103	214	1	lancet	lancet	NOUN
dti-2103	214	2	glob	glob	PROPN
dti-2103	214	3	health	health	NOUN
dti-2103	214	4	.	.	PUNCT
dti-2103	215	1	2019;7	2019;7	NOUN
dti-2103	215	2	:	:	PUNCT
dti-2103	215	3	e735	e735	PROPN
dti-2103	215	4	-	-	PUNCT
dti-2103	215	5	e747	e747	PROPN
dti-2103	215	6	.	.	PROPN
dti-2103	216	1	5	5	NUM
dti-2103	216	2	.	.	X
dti-2103	216	3	kim	kim	PROPN
dti-2103	216	4	sh	sh	PROPN
dti-2103	216	5	,	,	PUNCT
dti-2103	216	6	song	song	PROPN
dti-2103	216	7	jh	jh	PROPN
dti-2103	216	8	,	,	PUNCT
dti-2103	216	9	chung	chung	PROPN
dti-2103	216	10	dr	dr	PROPN
dti-2103	216	11	,	,	PUNCT
dti-2103	216	12	et	et	PROPN
dti-2103	216	13	al	al	PROPN
dti-2103	216	14	.	.	PUNCT
dti-2103	217	1	changing	change	VERB
dti-2103	217	2	trends	trend	NOUN
dti-2103	217	3	in	in	ADP
dti-2103	217	4	antimicrobial	antimicrobial	ADJ
dti-2103	217	5	resistance	resistance	NOUN
dti-2103	217	6	and	and	CCONJ
dti-2103	217	7	serotypes	serotype	NOUN
dti-2103	217	8	of	of	ADP
dti-2103	217	9	streptococcus	streptococcus	NOUN
dti-2103	217	10	pneumoniae	pneumoniae	ADJ
dti-2103	217	11	isolates	isolate	NOUN
dti-2103	217	12	in	in	ADP
dti-2103	217	13	asian	asian	ADJ
dti-2103	217	14	countries	country	NOUN
dti-2103	217	15	:	:	PUNCT
dti-2103	217	16	an	an	DET
dti-2103	217	17	asian	asian	ADJ
dti-2103	217	18	network	network	NOUN
dti-2103	217	19	for	for	ADP
dti-2103	217	20	surveillance	surveillance	NOUN
dti-2103	217	21	of	of	ADP
dti-2103	217	22	resistant	resistant	ADJ
dti-2103	217	23	pathogens	pathogen	NOUN
dti-2103	217	24	(	(	PUNCT
dti-2103	217	25	ansorp	ansorp	PROPN
dti-2103	217	26	)	)	PUNCT
dti-2103	217	27	study	study	NOUN
dti-2103	217	28	.	.	PUNCT
dti-2103	218	1	antimicrob	antimicrob	PROPN
dti-2103	218	2	agents	agents	PROPN
dti-2103	218	3	chemother	chemother	PROPN
dti-2103	218	4	.	.	PUNCT
dti-2103	219	1	2012;56:1418	2012;56:1418	NUM
dti-2103	219	2	-	-	SYM
dti-2103	219	3	1426	1426	NUM
dti-2103	219	4	.	.	PUNCT
dti-2103	220	1	6	6	NUM
dti-2103	220	2	.	.	X
dti-2103	220	3	azarian	azarian	PROPN
dti-2103	220	4	t	t	PROPN
dti-2103	220	5	,	,	PUNCT
dti-2103	220	6	grant	grant	PROPN
dti-2103	220	7	lr	lr	PROPN
dti-2103	220	8	,	,	PUNCT
dti-2103	220	9	arnold	arnold	PROPN
dti-2103	220	10	bj	bj	PROPN
dti-2103	220	11	,	,	PUNCT
dti-2103	220	12	et	et	PROPN
dti-2103	220	13	al	al	PROPN
dti-2103	220	14	.	.	PUNCT
dti-2103	221	1	the	the	DET
dti-2103	221	2	impact	impact	NOUN
dti-2103	221	3	of	of	ADP
dti-2103	221	4	serotypespecific	serotypespecific	ADJ
dti-2103	221	5	vaccination	vaccination	NOUN
dti-2103	221	6	on	on	ADP
dti-2103	221	7	phylodynamic	phylodynamic	ADJ
dti-2103	221	8	parameters	parameter	NOUN
dti-2103	221	9	of	of	ADP
dti-2103	221	10	streptococcus	streptococcus	NOUN
dti-2103	221	11	pneumoniae	pneumoniae	ADJ
dti-2103	221	12	and	and	CCONJ
dti-2103	221	13	the	the	DET
dti-2103	221	14	pneumococcal	pneumococcal	ADJ
dti-2103	221	15	pan	pan	NOUN
dti-2103	221	16	-	-	NOUN
dti-2103	221	17	genome	genome	NOUN
dti-2103	221	18	.	.	PUNCT
dti-2103	222	1	plos	plos	PROPN
dti-2103	222	2	pathog	pathog	PROPN
dti-2103	222	3	.	.	PUNCT
dti-2103	223	1	2018;14	2018;14	NUM
dti-2103	223	2	:	:	PUNCT
dti-2103	223	3	e1006966	e1006966	NOUN
dti-2103	223	4	.	.	PROPN
dti-2103	224	1	7	7	NUM
dti-2103	224	2	.	.	X
dti-2103	224	3	mclaughlin	mclaughlin	PROPN
dti-2103	224	4	jm	jm	PROPN
dti-2103	224	5	,	,	PUNCT
dti-2103	224	6	jiang	jiang	PROPN
dti-2103	224	7	q	q	PROPN
dti-2103	224	8	,	,	PUNCT
dti-2103	224	9	isturiz	isturiz	NOUN
dti-2103	224	10	re	re	NOUN
dti-2103	224	11	,	,	PUNCT
dti-2103	224	12	et	et	PROPN
dti-2103	224	13	al	al	PROPN
dti-2103	224	14	.	.	PROPN
dti-2103	224	15	effectiveness	effectiveness	NOUN
dti-2103	224	16	of	of	ADP
dti-2103	224	17	13	13	NUM
dti-2103	224	18	valent	valent	NOUN
dti-2103	224	19	pneumococcal	pneumococcal	ADJ
dti-2103	224	20	conjugate	conjugate	ADJ
dti-2103	224	21	vaccine	vaccine	NOUN
dti-2103	224	22	against	against	ADP
dti-2103	224	23	hospitalization	hospitalization	NOUN
dti-2103	224	24	for	for	ADP
dti-2103	224	25	community	community	NOUN
dti-2103	224	26	-	-	PUNCT
dti-2103	224	27	acquired	acquire	VERB
dti-2103	224	28	pneumonia	pneumonia	NOUN
dti-2103	224	29	in	in	ADP
dti-2103	224	30	older	old	ADJ
dti-2103	224	31	us	us	PROPN
dti-2103	224	32	adults	adult	NOUN
dti-2103	224	33	:	:	PUNCT
dti-2103	224	34	a	a	DET
dti-2103	224	35	testnegative	testnegative	ADJ
dti-2103	224	36	design	design	NOUN
dti-2103	224	37	.	.	PUNCT
dti-2103	225	1	clin	clin	PROPN
dti-2103	225	2	infect	infect	PROPN
dti-2103	225	3	dis	dis	PROPN
dti-2103	225	4	.	.	PUNCT
dti-2103	226	1	2018;67:1498	2018;67:1498	NUM
dti-2103	226	2	-	-	SYM
dti-2103	226	3	1506	1506	NUM
dti-2103	226	4	.	.	PUNCT
dti-2103	227	1	8	8	X
dti-2103	227	2	.	.	X
dti-2103	227	3	mitchell	mitchell	PROPN
dti-2103	227	4	am	am	PROPN
dti-2103	227	5	,	,	PUNCT
dti-2103	227	6	mitchell	mitchell	PROPN
dti-2103	227	7	tj	tj	PROPN
dti-2103	227	8	.	.	PROPN
dti-2103	227	9	streptococcus	streptococcus	NOUN
dti-2103	227	10	pneumoniae	pneumoniae	ADV
dti-2103	227	11	:	:	PUNCT
dti-2103	227	12	virulence	virulence	NOUN
dti-2103	227	13	factors	factor	NOUN
dti-2103	227	14	and	and	CCONJ
dti-2103	227	15	variation	variation	NOUN
dti-2103	227	16	.	.	PUNCT
dti-2103	228	1	clin	clin	PROPN
dti-2103	228	2	microbiol	microbiol	PROPN
dti-2103	228	3	infect	infect	VERB
dti-2103	228	4	.	.	PUNCT
dti-2103	229	1	2010;16:411	2010;16:411	PROPN
dti-2103	229	2	-	-	NOUN
dti-2103	229	3	418	418	NUM
dti-2103	229	4	.	.	PUNCT
dti-2103	230	1	9	9	NUM
dti-2103	230	2	.	.	PUNCT
dti-2103	230	3	brooks	brooks	PROPN
dti-2103	230	4	lrk	lrk	PROPN
dti-2103	230	5	,	,	PUNCT
dti-2103	230	6	mias	mias	PROPN
dti-2103	230	7	gi	gi	PROPN
dti-2103	230	8	.	.	PROPN
dti-2103	230	9	streptococcus	streptococcus	VERB
dti-2103	230	10	pneumoniae	pneumoniae	ADJ
dti-2103	230	11	’s	’s	PART
dti-2103	230	12	virulence	virulence	NOUN
dti-2103	230	13	and	and	CCONJ
dti-2103	230	14	host	host	NOUN
dti-2103	230	15	immunity	immunity	NOUN
dti-2103	230	16	:	:	PUNCT
dti-2103	230	17	aging	aging	NOUN
dti-2103	230	18	,	,	PUNCT
dti-2103	230	19	diagnostics	diagnostic	NOUN
dti-2103	230	20	,	,	PUNCT
dti-2103	230	21	and	and	CCONJ
dti-2103	230	22	prevention	prevention	NOUN
dti-2103	230	23	.	.	PUNCT
dti-2103	231	1	front	front	ADJ
dti-2103	231	2	immunol	immunol	NOUN
dti-2103	231	3	.	.	PUNCT
dti-2103	232	1	2018;9:1366	2018;9:1366	NOUN
dti-2103	232	2	.	.	PUNCT
dti-2103	233	1	10	10	NUM
dti-2103	233	2	.	.	PUNCT
dti-2103	233	3	magee	magee	PROPN
dti-2103	233	4	ad	ad	PROPN
dti-2103	233	5	,	,	PUNCT
dti-2103	233	6	yother	yother	PROPN
dti-2103	233	7	j.	j.	PROPN
dti-2103	233	8	requirement	requirement	PROPN
dti-2103	233	9	for	for	ADP
dti-2103	233	10	capsule	capsule	NOUN
dti-2103	233	11	in	in	ADP
dti-2103	233	12	colonization	colonization	NOUN
dti-2103	233	13	by	by	ADP
dti-2103	233	14	streptococcus	streptococcus	NOUN
dti-2103	233	15	pneumoniae	pneumoniae	NOUN
dti-2103	233	16	.	.	PUNCT
dti-2103	234	1	infect	infect	VERB
dti-2103	234	2	immun	immun	PROPN
dti-2103	234	3	.	.	PUNCT
dti-2103	235	1	2001;69:3755	2001;69:3755	NUM
dti-2103	235	2	-	-	SYM
dti-2103	235	3	3761	3761	NUM
dti-2103	235	4	.	.	PUNCT
dti-2103	236	1	11	11	NUM
dti-2103	236	2	.	.	X
dti-2103	237	1	shainheit	shainheit	PROPN
dti-2103	237	2	mg	mg	PROPN
dti-2103	237	3	,	,	PUNCT
dti-2103	237	4	mulé	mulé	VERB
dti-2103	237	5	m	m	PROPN
dti-2103	237	6	,	,	PUNCT
dti-2103	237	7	camilli	camilli	PROPN
dti-2103	237	8	a.	a.	NOUN
dti-2103	237	9	the	the	DET
dti-2103	237	10	core	core	NOUN
dti-2103	237	11	promoter	promoter	NOUN
dti-2103	237	12	of	of	ADP
dti-2103	237	13	the	the	DET
dti-2103	237	14	capsule	capsule	NOUN
dti-2103	237	15	operon	operon	NOUN
dti-2103	237	16	of	of	ADP
dti-2103	237	17	streptococcus	streptococcus	NOUN
dti-2103	237	18	pneumoniae	pneumoniae	ADJ
dti-2103	237	19	is	be	AUX
dti-2103	237	20	necessary	necessary	ADJ
dti-2103	237	21	for	for	ADP
dti-2103	237	22	colonization	colonization	NOUN
dti-2103	237	23	and	and	CCONJ
dti-2103	237	24	invasive	invasive	ADJ
dti-2103	237	25	disease	disease	NOUN
dti-2103	237	26	.	.	PUNCT
dti-2103	238	1	infect	infect	VERB
dti-2103	238	2	immun	immun	PROPN
dti-2103	238	3	.	.	PUNCT
dti-2103	239	1	2014;82:694	2014;82:694	PROPN
dti-2103	239	2	-	-	SYM
dti-2103	239	3	705	705	NUM
dti-2103	239	4	.	.	PUNCT
dti-2103	239	5	12	12	NUM
dti-2103	239	6	.	.	PUNCT
dti-2103	240	1	garcía	garcía	PROPN
dti-2103	240	2	e	e	NOUN
dti-2103	240	3	,	,	PUNCT
dti-2103	240	4	llull	llull	NOUN
dti-2103	240	5	d	d	PROPN
dti-2103	240	6	,	,	PUNCT
dti-2103	240	7	lópez	lópez	PROPN
dti-2103	240	8	r.	r.	PROPN
dti-2103	240	9	functional	functional	PROPN
dti-2103	240	10	organization	organization	NOUN
dti-2103	240	11	of	of	ADP
dti-2103	240	12	the	the	DET
dti-2103	240	13	gene	gene	NOUN
dti-2103	240	14	cluster	cluster	NOUN
dti-2103	240	15	involved	involve	VERB
dti-2103	240	16	in	in	ADP
dti-2103	240	17	the	the	DET
dti-2103	240	18	synthesis	synthesis	NOUN
dti-2103	240	19	of	of	ADP
dti-2103	240	20	the	the	DET
dti-2103	240	21	pneumococcal	pneumococcal	ADJ
dti-2103	240	22	capsule	capsule	NOUN
dti-2103	240	23	.	.	PUNCT
dti-2103	241	1	int	int	PROPN
dti-2103	241	2	microbiol	microbiol	PROPN
dti-2103	241	3	.	.	PUNCT
dti-2103	242	1	1999;2:169	1999;2:169	X
dti-2103	242	2	-	-	SYM
dti-2103	242	3	176	176	NUM
dti-2103	242	4	.	.	PUNCT
dti-2103	243	1	13	13	NUM
dti-2103	243	2	.	.	PUNCT
dti-2103	244	1	garcía	garcía	PROPN
dti-2103	244	2	e	e	NOUN
dti-2103	244	3	,	,	PUNCT
dti-2103	244	4	llull	llull	PROPN
dti-2103	244	5	d	d	PROPN
dti-2103	244	6	,	,	PUNCT
dti-2103	244	7	muñoz	muñoz	PROPN
dti-2103	244	8	r	r	PROPN
dti-2103	244	9	,	,	PUNCT
dti-2103	244	10	mollerach	mollerach	NOUN
dti-2103	244	11	m	m	PROPN
dti-2103	244	12	,	,	PUNCT
dti-2103	244	13	lópez	lópez	PROPN
dti-2103	244	14	r.	r.	PROPN
dti-2103	244	15	current	current	ADJ
dti-2103	244	16	trends	trend	NOUN
dti-2103	244	17	in	in	ADP
dti-2103	244	18	capsular	capsular	ADJ
dti-2103	244	19	polysaccharide	polysaccharide	NOUN
dti-2103	244	20	biosynthesis	biosynthesis	NOUN
dti-2103	244	21	of	of	ADP
dti-2103	244	22	streptococcus	streptococcus	NOUN
dti-2103	244	23	pneumoniae	pneumoniae	NOUN
dti-2103	244	24	.	.	PUNCT
dti-2103	245	1	res	re	NOUN
dti-2103	245	2	microbiol	microbiol	PROPN
dti-2103	245	3	.	.	PUNCT
dti-2103	246	1	2000;151:429	2000;151:429	NUM
dti-2103	246	2	-	-	SYM
dti-2103	246	3	435	435	NUM
dti-2103	246	4	.	.	PUNCT
dti-2103	247	1	sharma	sharma	PROPN
dti-2103	247	2	et	et	PROPN
dti-2103	247	3	al	al	PROPN
dti-2103	247	4	33	33	NUM
dti-2103	247	5	©	©	PROPN
dti-2103	247	6	2020	2020	NUM
dti-2103	247	7	the	the	DET
dti-2103	247	8	authors	author	NOUN
dti-2103	247	9	.	.	PUNCT
dti-2103	248	1	published	publish	VERB
dti-2103	248	2	by	by	ADP
dti-2103	248	3	aboutscience	aboutscience	NOUN
dti-2103	248	4	14	14	NUM
dti-2103	248	5	.	.	PUNCT
dti-2103	249	1	mollerach	mollerach	PROPN
dti-2103	249	2	m	m	PROPN
dti-2103	249	3	,	,	PUNCT
dti-2103	249	4	lópez	lópez	PROPN
dti-2103	249	5	r	r	NOUN
dti-2103	249	6	,	,	PUNCT
dti-2103	249	7	garcía	garcía	ADJ
dti-2103	249	8	e.	e.	PROPN
dti-2103	249	9	characterization	characterization	NOUN
dti-2103	249	10	of	of	ADP
dti-2103	249	11	the	the	DET
dti-2103	249	12	galu	galu	NOUN
dti-2103	249	13	gene	gene	NOUN
dti-2103	249	14	of	of	ADP
dti-2103	249	15	streptococcus	streptococcus	NOUN
dti-2103	249	16	pneumoniae	pneumoniae	ADJ
dti-2103	249	17	encoding	encode	VERB
dti-2103	249	18	a	a	DET
dti-2103	249	19	uridine	uridine	NOUN
dti-2103	249	20	diphosphoglucose	diphosphoglucose	ADJ
dti-2103	249	21	pyrophosphorylase	pyrophosphorylase	NOUN
dti-2103	249	22	:	:	PUNCT
dti-2103	249	23	a	a	DET
dti-2103	249	24	gene	gene	NOUN
dti-2103	249	25	essential	essential	ADJ
dti-2103	249	26	for	for	ADP
dti-2103	249	27	capsular	capsular	VERB
dti-2103	249	28	polysaccharide	polysaccharide	NOUN
dti-2103	249	29	biosynthesis	biosynthesis	NOUN
dti-2103	249	30	.	.	PUNCT
dti-2103	250	1	j	j	PROPN
dti-2103	250	2	exp	exp	NOUN
dti-2103	250	3	med	med	PROPN
dti-2103	250	4	.	.	PUNCT
dti-2103	251	1	1998;188:2047	1998;188:2047	NUM
dti-2103	251	2	-	-	SYM
dti-2103	251	3	2056	2056	NUM
dti-2103	251	4	.	.	PUNCT
dti-2103	252	1	15	15	NUM
dti-2103	252	2	.	.	PUNCT
dti-2103	253	1	chang	chang	PROPN
dti-2103	253	2	hy	hy	PROPN
dti-2103	253	3	,	,	PUNCT
dti-2103	253	4	lee	lee	PROPN
dti-2103	253	5	jh	jh	PROPN
dti-2103	253	6	,	,	PUNCT
dti-2103	253	7	deng	deng	PROPN
dti-2103	253	8	wl	wl	PROPN
dti-2103	253	9	,	,	PUNCT
dti-2103	253	10	fu	fu	PROPN
dti-2103	253	11	tf	tf	PROPN
dti-2103	253	12	,	,	PUNCT
dti-2103	253	13	peng	peng	PROPN
dti-2103	253	14	hl	hl	PROPN
dti-2103	253	15	.	.	PUNCT
dti-2103	253	16	virulence	virulence	NOUN
dti-2103	253	17	and	and	CCONJ
dti-2103	253	18	outer	outer	ADJ
dti-2103	253	19	membrane	membrane	NOUN
dti-2103	253	20	properties	property	NOUN
dti-2103	253	21	of	of	ADP
dti-2103	253	22	a	a	DET
dti-2103	253	23	galu	galu	NOUN
dti-2103	253	24	mutant	mutant	NOUN
dti-2103	253	25	of	of	ADP
dti-2103	253	26	klebsiella	klebsiella	NOUN
dti-2103	253	27	pneumoniae	pneumoniae	ADJ
dti-2103	253	28	cg43	cg43	PROPN
dti-2103	253	29	.	.	PUNCT
dti-2103	254	1	microb	microb	PROPN
dti-2103	254	2	pathog	pathog	PROPN
dti-2103	254	3	.	.	PUNCT
dti-2103	255	1	1996;20:255	1996;20:255	NUM
dti-2103	255	2	-	-	NUM
dti-2103	255	3	261	261	NUM
dti-2103	255	4	.	.	PUNCT
dti-2103	256	1	16	16	NUM
dti-2103	256	2	.	.	PUNCT
dti-2103	257	1	priebe	priebe	PROPN
dti-2103	257	2	gp	gp	NOUN
dti-2103	257	3	,	,	PUNCT
dti-2103	257	4	dean	dean	PROPN
dti-2103	257	5	cr	cr	PROPN
dti-2103	257	6	,	,	PUNCT
dti-2103	257	7	zaidi	zaidi	PROPN
dti-2103	257	8	t	t	PROPN
dti-2103	257	9	,	,	PUNCT
dti-2103	257	10	et	et	PROPN
dti-2103	257	11	al	al	PROPN
dti-2103	257	12	.	.	PUNCT
dti-2103	258	1	the	the	DET
dti-2103	258	2	galu	galu	NOUN
dti-2103	258	3	gene	gene	NOUN
dti-2103	258	4	of	of	ADP
dti-2103	258	5	pseudomonas	pseudomona	NOUN
dti-2103	258	6	aeruginosa	aeruginosa	NOUN
dti-2103	258	7	is	be	AUX
dti-2103	258	8	required	require	VERB
dti-2103	258	9	for	for	ADP
dti-2103	258	10	corneal	corneal	ADJ
dti-2103	258	11	infection	infection	NOUN
dti-2103	258	12	and	and	CCONJ
dti-2103	258	13	efficient	efficient	ADJ
dti-2103	258	14	systemic	systemic	ADJ
dti-2103	258	15	spread	spread	NOUN
dti-2103	258	16	following	follow	VERB
dti-2103	258	17	pneumonia	pneumonia	NOUN
dti-2103	258	18	but	but	CCONJ
dti-2103	258	19	not	not	PART
dti-2103	258	20	for	for	ADP
dti-2103	258	21	infection	infection	NOUN
dti-2103	258	22	confined	confine	VERB
dti-2103	258	23	to	to	ADP
dti-2103	258	24	the	the	DET
dti-2103	258	25	lung	lung	NOUN
dti-2103	258	26	.	.	PUNCT
dti-2103	259	1	infect	infect	VERB
dti-2103	259	2	immun	immun	PROPN
dti-2103	259	3	.	.	PUNCT
dti-2103	260	1	2004;72:4224	2004;72:4224	NUM
dti-2103	260	2	-	-	SYM
dti-2103	260	3	4232	4232	NUM
dti-2103	260	4	.	.	PUNCT
dti-2103	261	1	17	17	NUM
dti-2103	261	2	.	.	PUNCT
dti-2103	262	1	bonofiglio	bonofiglio	DET
dti-2103	262	2	l	l	NOUN
dti-2103	262	3	,	,	PUNCT
dti-2103	262	4	garcía	garcía	ADJ
dti-2103	262	5	e	e	NOUN
dti-2103	262	6	,	,	PUNCT
dti-2103	262	7	mollerach	mollerach	NOUN
dti-2103	262	8	m.	m.	NOUN
dti-2103	262	9	biochemical	biochemical	ADJ
dti-2103	262	10	characterization	characterization	NOUN
dti-2103	262	11	of	of	ADP
dti-2103	262	12	the	the	DET
dti-2103	262	13	pneumococcal	pneumococcal	ADJ
dti-2103	262	14	glucose	glucose	NOUN
dti-2103	262	15	1	1	NUM
dti-2103	262	16	-	-	PUNCT
dti-2103	262	17	phosphate	phosphate	NOUN
dti-2103	262	18	uridylyltransferase	uridylyltransferase	NOUN
dti-2103	262	19	(	(	PUNCT
dti-2103	262	20	galu	galu	NOUN
dti-2103	262	21	)	)	PUNCT
dti-2103	262	22	essential	essential	ADJ
dti-2103	262	23	for	for	ADP
dti-2103	262	24	capsule	capsule	NOUN
dti-2103	262	25	biosynthesis	biosynthesis	NOUN
dti-2103	262	26	.	.	PUNCT
dti-2103	263	1	curr	curr	PROPN
dti-2103	263	2	microbiol	microbiol	PROPN
dti-2103	263	3	.	.	PUNCT
dti-2103	264	1	2005;51:217	2005;51:217	NUM
dti-2103	264	2	-	-	SYM
dti-2103	264	3	221	221	NUM
dti-2103	264	4	.	.	PUNCT
dti-2103	265	1	18	18	NUM
dti-2103	265	2	.	.	PUNCT
dti-2103	266	1	bonofiglio	bonofiglio	DET
dti-2103	266	2	l	l	NOUN
dti-2103	266	3	,	,	PUNCT
dti-2103	266	4	garcía	garcía	ADJ
dti-2103	266	5	e	e	NOUN
dti-2103	266	6	,	,	PUNCT
dti-2103	266	7	mollerach	mollerach	NOUN
dti-2103	266	8	m.	m.	NOUN
dti-2103	266	9	the	the	DET
dti-2103	266	10	galu	galu	NOUN
dti-2103	266	11	gene	gene	NOUN
dti-2103	266	12	expression	expression	NOUN
dti-2103	266	13	in	in	ADP
dti-2103	266	14	streptococcus	streptococcus	NOUN
dti-2103	266	15	pneumoniae	pneumoniae	NOUN
dti-2103	266	16	.	.	PUNCT
dti-2103	267	1	fems	fems	PROPN
dti-2103	267	2	microbiol	microbiol	PROPN
dti-2103	267	3	lett	lett	PROPN
dti-2103	267	4	.	.	PUNCT
dti-2103	268	1	2012;332:47	2012;332:47	NUM
dti-2103	268	2	-	-	SYM
dti-2103	268	3	53	53	NUM
dti-2103	268	4	.	.	NOUN
dti-2103	268	5	19	19	NUM
dti-2103	268	6	.	.	PUNCT
dti-2103	268	7	cools	cool	VERB
dti-2103	268	8	f	f	NUM
dti-2103	268	9	,	,	PUNCT
dti-2103	268	10	torfs	torf	NOUN
dti-2103	268	11	e	e	NOUN
dti-2103	268	12	,	,	PUNCT
dti-2103	268	13	vanhoutte	vanhoutte	PROPN
dti-2103	268	14	b	b	PROPN
dti-2103	268	15	,	,	PUNCT
dti-2103	268	16	et	et	PROPN
dti-2103	268	17	al	al	PROPN
dti-2103	268	18	.	.	PROPN
dti-2103	268	19	streptococcus	streptococcus	VERB
dti-2103	268	20	pneumoniae	pneumoniae	ADJ
dti-2103	268	21	galu	galu	NOUN
dti-2103	268	22	gene	gene	NOUN
dti-2103	268	23	mutation	mutation	NOUN
dti-2103	268	24	has	have	VERB
dti-2103	268	25	a	a	DET
dti-2103	268	26	direct	direct	ADJ
dti-2103	268	27	effect	effect	NOUN
dti-2103	268	28	on	on	ADP
dti-2103	268	29	biofilm	biofilm	NOUN
dti-2103	268	30	growth	growth	NOUN
dti-2103	268	31	,	,	PUNCT
dti-2103	268	32	adherence	adherence	NOUN
dti-2103	268	33	and	and	CCONJ
dti-2103	268	34	phagocytosis	phagocytosis	NOUN
dti-2103	268	35	in	in	ADP
dti-2103	268	36	vitro	vitro	NOUN
dti-2103	268	37	and	and	CCONJ
dti-2103	268	38	pathogenicity	pathogenicity	NOUN
dti-2103	268	39	in	in	ADP
dti-2103	268	40	vivo	vivo	NOUN
dti-2103	268	41	.	.	PUNCT
dti-2103	269	1	pathog	pathog	PROPN
dti-2103	269	2	dis	dis	PROPN
dti-2103	269	3	.	.	PUNCT
dti-2103	270	1	2018;76	2018;76	NUM
dti-2103	270	2	.	.	PROPN
dti-2103	271	1	20	20	NUM
dti-2103	271	2	.	.	PUNCT
dti-2103	272	1	frey	frey	PROPN
dti-2103	272	2	pa	pa	PROPN
dti-2103	272	3	.	.	PUNCT
dti-2103	273	1	the	the	DET
dti-2103	273	2	leloir	leloir	PROPN
dti-2103	273	3	pathway	pathway	NOUN
dti-2103	273	4	:	:	PUNCT
dti-2103	273	5	a	a	DET
dti-2103	273	6	mechanistic	mechanistic	ADJ
dti-2103	273	7	imperative	imperative	NOUN
dti-2103	273	8	for	for	ADP
dti-2103	273	9	three	three	NUM
dti-2103	273	10	enzymes	enzyme	NOUN
dti-2103	273	11	to	to	PART
dti-2103	273	12	change	change	VERB
dti-2103	273	13	the	the	DET
dti-2103	273	14	stereochemical	stereochemical	ADJ
dti-2103	273	15	configuration	configuration	NOUN
dti-2103	273	16	of	of	ADP
dti-2103	273	17	a	a	DET
dti-2103	273	18	single	single	ADJ
dti-2103	273	19	carbon	carbon	NOUN
dti-2103	273	20	in	in	ADP
dti-2103	273	21	galactose	galactose	NOUN
dti-2103	273	22	.	.	PUNCT
dti-2103	274	1	faseb	faseb	PROPN
dti-2103	274	2	j.	j.	PROPN
dti-2103	274	3	1996;10:461	1996;10:461	PROPN
dti-2103	274	4	-	-	PROPN
dti-2103	274	5	470	470	NUM
dti-2103	274	6	.	.	PUNCT
dti-2103	275	1	21	21	NUM
dti-2103	275	2	.	.	PUNCT
dti-2103	276	1	alvaro	alvaro	PROPN
dti-2103	276	2	berbis	berbis	PROPN
dti-2103	276	3	m	m	PROPN
dti-2103	276	4	,	,	PUNCT
dti-2103	276	5	maria	maria	PROPN
dti-2103	276	6	sanchez	sanchez	PROPN
dti-2103	276	7	-	-	PUNCT
dti-2103	276	8	puelles	puelles	PROPN
dti-2103	276	9	j	j	PROPN
dti-2103	276	10	,	,	PUNCT
dti-2103	276	11	javier	javier	PROPN
dti-2103	276	12	canada	canada	PROPN
dti-2103	277	1	f	f	PROPN
dti-2103	277	2	,	,	PUNCT
dti-2103	277	3	jimenez	jimenez	PROPN
dti-2103	277	4	-	-	PUNCT
dti-2103	277	5	barbero	barbero	PROPN
dti-2103	277	6	j.	j.	PROPN
dti-2103	277	7	structure	structure	PROPN
dti-2103	277	8	and	and	CCONJ
dti-2103	277	9	function	function	NOUN
dti-2103	277	10	of	of	ADP
dti-2103	277	11	prokaryotic	prokaryotic	ADJ
dti-2103	277	12	udpglucose	udpglucose	ADJ
dti-2103	277	13	pyrophosphorylase	pyrophosphorylase	NOUN
dti-2103	277	14	,	,	PUNCT
dti-2103	277	15	a	a	DET
dti-2103	277	16	drug	drug	NOUN
dti-2103	277	17	target	target	NOUN
dti-2103	277	18	candidate	candidate	NOUN
dti-2103	277	19	.	.	PUNCT
dti-2103	278	1	curr	curr	PROPN
dti-2103	278	2	med	med	PROPN
dti-2103	278	3	chem	chem	NOUN
dti-2103	278	4	.	.	PUNCT
dti-2103	279	1	2015;22:1687	2015;22:1687	NUM
dti-2103	279	2	-	-	SYM
dti-2103	279	3	1697	1697	NUM
dti-2103	279	4	.	.	PUNCT
dti-2103	280	1	22	22	NUM
dti-2103	280	2	.	.	PUNCT
dti-2103	281	1	mollerach	mollerach	PROPN
dti-2103	281	2	m	m	PROPN
dti-2103	281	3	,	,	PUNCT
dti-2103	281	4	garcía	garcía	PROPN
dti-2103	281	5	e.	e.	PROPN
dti-2103	281	6	the	the	DET
dti-2103	281	7	galu	galu	NOUN
dti-2103	281	8	gene	gene	NOUN
dti-2103	281	9	of	of	ADP
dti-2103	281	10	streptococcus	streptococcus	NOUN
dti-2103	281	11	pneumoniae	pneumoniae	ADJ
dti-2103	281	12	that	that	SCONJ
dti-2103	281	13	codes	code	VERB
dti-2103	281	14	for	for	ADP
dti-2103	281	15	a	a	DET
dti-2103	281	16	udp	udp	NOUN
dti-2103	281	17	-	-	NOUN
dti-2103	281	18	glucose	glucose	NOUN
dti-2103	281	19	pyrophosphorylase	pyrophosphorylase	NOUN
dti-2103	281	20	is	be	AUX
dti-2103	281	21	highly	highly	ADV
dti-2103	281	22	polymorphic	polymorphic	ADJ
dti-2103	281	23	and	and	CCONJ
dti-2103	281	24	suitable	suitable	ADJ
dti-2103	281	25	for	for	ADP
dti-2103	281	26	molecular	molecular	ADJ
dti-2103	281	27	typing	typing	NOUN
dti-2103	281	28	and	and	CCONJ
dti-2103	281	29	phylogenetic	phylogenetic	ADJ
dti-2103	281	30	studies	study	NOUN
dti-2103	281	31	.	.	PUNCT
dti-2103	282	1	gene	gene	NOUN
dti-2103	282	2	.	.	PUNCT
dti-2103	283	1	2000;260:77	2000;260:77	NUM
dti-2103	283	2	-	-	SYM
dti-2103	283	3	86	86	NUM
dti-2103	283	4	.	.	PUNCT
dti-2103	284	1	23	23	NUM
dti-2103	284	2	.	.	PUNCT
dti-2103	285	1	zavala	zavala	PROPN
dti-2103	285	2	a	a	PRON
dti-2103	285	3	,	,	PUNCT
dti-2103	285	4	kovacec	kovacec	AUX
dti-2103	285	5	v	v	NOUN
dti-2103	285	6	,	,	PUNCT
dti-2103	285	7	levín	levín	VERB
dti-2103	285	8	g	g	PROPN
dti-2103	285	9	,	,	PUNCT
dti-2103	285	10	et	et	PROPN
dti-2103	285	11	al	al	PROPN
dti-2103	285	12	.	.	PUNCT
dti-2103	285	13	screening	screen	VERB
dti-2103	285	14	assay	assay	ADV
dti-2103	285	15	for	for	ADP
dti-2103	285	16	inhibitors	inhibitor	NOUN
dti-2103	285	17	of	of	ADP
dti-2103	285	18	a	a	DET
dti-2103	285	19	recombinant	recombinant	ADJ
dti-2103	285	20	streptococcus	streptococcus	NOUN
dti-2103	285	21	pneumoniae	pneumoniae	ADJ
dti-2103	285	22	udp	udp	NOUN
dti-2103	285	23	-	-	NOUN
dti-2103	285	24	glucose	glucose	NOUN
dti-2103	285	25	pyrophosphorylase	pyrophosphorylase	NOUN
dti-2103	285	26	.	.	PUNCT
dti-2103	286	1	j	j	PROPN
dti-2103	286	2	enzyme	enzyme	NOUN
dti-2103	286	3	inhib	inhib	VERB
dti-2103	286	4	med	med	ADJ
dti-2103	286	5	chem	chem	NOUN
dti-2103	286	6	.	.	PUNCT
dti-2103	287	1	2017;32:203	2017;32:203	NOUN
dti-2103	287	2	-	-	SYM
dti-2103	287	3	207	207	NUM
dti-2103	287	4	.	.	PUNCT
dti-2103	288	1	24	24	NUM
dti-2103	288	2	.	.	PUNCT
dti-2103	289	1	twentyman	twentyman	NOUN
dti-2103	289	2	pr	pr	PROPN
dti-2103	289	3	,	,	PUNCT
dti-2103	289	4	luscombe	luscombe	NOUN
dti-2103	289	5	m.	m.	NOUN
dti-2103	289	6	a	a	DET
dti-2103	289	7	study	study	NOUN
dti-2103	289	8	of	of	ADP
dti-2103	289	9	some	some	DET
dti-2103	289	10	variables	variable	NOUN
dti-2103	289	11	in	in	ADP
dti-2103	289	12	a	a	DET
dti-2103	289	13	tetrazolium	tetrazolium	NOUN
dti-2103	289	14	dye	dye	NOUN
dti-2103	289	15	(	(	PUNCT
dti-2103	289	16	mtt	mtt	NOUN
dti-2103	289	17	)	)	PUNCT
dti-2103	289	18	based	base	VERB
dti-2103	289	19	assay	assay	PROPN
dti-2103	289	20	for	for	ADP
dti-2103	289	21	cell	cell	NOUN
dti-2103	289	22	growth	growth	NOUN
dti-2103	289	23	and	and	CCONJ
dti-2103	289	24	chemosensitivity	chemosensitivity	NOUN
dti-2103	289	25	.	.	PUNCT
dti-2103	290	1	br	br	PROPN
dti-2103	290	2	j	j	PROPN
dti-2103	290	3	cancer	cancer	NOUN
dti-2103	290	4	.	.	PUNCT
dti-2103	291	1	1987;56:279	1987;56:279	NUM
dti-2103	291	2	-	-	SYM
dti-2103	291	3	285	285	NUM
dti-2103	291	4	.	.	PUNCT
dti-2103	292	1	25	25	NUM
dti-2103	292	2	.	.	PUNCT
dti-2103	293	1	hara	hara	PROPN
dti-2103	293	2	-	-	PUNCT
dti-2103	293	3	kaonga	kaonga	PROPN
dti-2103	293	4	b	b	PROPN
dti-2103	293	5	,	,	PUNCT
dti-2103	293	6	pistole	pistole	PROPN
dti-2103	293	7	tg	tg	PROPN
dti-2103	293	8	.	.	PUNCT
dti-2103	294	1	a	a	DET
dti-2103	294	2	dual	dual	ADJ
dti-2103	294	3	fluorescence	fluorescence	NOUN
dti-2103	294	4	flow	flow	NOUN
dti-2103	294	5	cytometric	cytometric	ADJ
dti-2103	294	6	analysis	analysis	NOUN
dti-2103	294	7	of	of	ADP
dti-2103	294	8	bacterial	bacterial	ADJ
dti-2103	294	9	adherence	adherence	NOUN
dti-2103	294	10	to	to	ADP
dti-2103	294	11	mammalian	mammalian	ADJ
dti-2103	294	12	host	host	NOUN
dti-2103	294	13	cells	cell	NOUN
dti-2103	294	14	.	.	PUNCT
dti-2103	295	1	j	j	PROPN
dti-2103	295	2	microbiol	microbiol	PROPN
dti-2103	295	3	methods	method	NOUN
dti-2103	295	4	.	.	PUNCT
dti-2103	296	1	2007;69:37	2007;69:37	NUM
dti-2103	296	2	-	-	SYM
dti-2103	296	3	43	43	NUM
dti-2103	296	4	.	.	PUNCT
dti-2103	297	1	26	26	NUM
dti-2103	297	2	.	.	PUNCT
dti-2103	297	3	hu	hu	PROPN
dti-2103	298	1	bt	bt	PROPN
dti-2103	298	2	,	,	PUNCT
dti-2103	298	3	yu	yu	PROPN
dti-2103	298	4	x	x	PROPN
dti-2103	298	5	,	,	PUNCT
dti-2103	298	6	jones	jones	PROPN
dti-2103	298	7	tr	tr	VERB
dti-2103	298	8	,	,	PUNCT
dti-2103	298	9	et	et	PROPN
dti-2103	298	10	al	al	PROPN
dti-2103	298	11	.	.	PROPN
dti-2103	298	12	approach	approach	NOUN
dti-2103	298	13	to	to	ADP
dti-2103	298	14	validating	validate	VERB
dti-2103	298	15	an	an	DET
dti-2103	298	16	opsonophagocytic	opsonophagocytic	ADJ
dti-2103	298	17	assay	assay	NOUN
dti-2103	298	18	for	for	ADP
dti-2103	298	19	streptococcus	streptococcus	NOUN
dti-2103	298	20	pneumoniae	pneumoniae	NOUN
dti-2103	298	21	.	.	PUNCT
dti-2103	299	1	clin	clin	PROPN
dti-2103	299	2	diagn	diagn	PROPN
dti-2103	299	3	lab	lab	NOUN
dti-2103	299	4	immunol	immunol	NOUN
dti-2103	299	5	.	.	PUNCT
dti-2103	300	1	2005;12:287	2005;12:287	NUM
dti-2103	300	2	-	-	SYM
dti-2103	300	3	295	295	NUM
dti-2103	300	4	.	.	PUNCT
dti-2103	301	1	27	27	NUM
dti-2103	301	2	.	.	PUNCT
dti-2103	302	1	kim	kim	PROPN
dti-2103	302	2	b	b	PROPN
dti-2103	302	3	,	,	PUNCT
dti-2103	302	4	jeong	jeong	PROPN
dti-2103	302	5	hk	hk	PROPN
dti-2103	302	6	,	,	PUNCT
dti-2103	302	7	kim	kim	PROPN
dti-2103	302	8	jh	jh	PROPN
dti-2103	302	9	,	,	PUNCT
dti-2103	302	10	lee	lee	PROPN
dti-2103	302	11	sy	sy	PROPN
dti-2103	302	12	,	,	PUNCT
dti-2103	302	13	jou	jou	PROPN
dti-2103	302	14	i	i	PROPN
dti-2103	302	15	,	,	PUNCT
dti-2103	302	16	joe	joe	PROPN
dti-2103	302	17	eh	eh	INTJ
dti-2103	302	18	.	.	PROPN
dti-2103	302	19	uridine	uridine	PROPN
dti-2103	302	20	5′-diphosphate	5′-diphosphate	PROPN
dti-2103	302	21	induces	induce	VERB
dti-2103	302	22	chemokine	chemokine	ADJ
dti-2103	302	23	expression	expression	NOUN
dti-2103	302	24	in	in	ADP
dti-2103	302	25	microglia	microglia	NOUN
dti-2103	302	26	and	and	CCONJ
dti-2103	302	27	astrocytes	astrocyte	VERB
dti-2103	302	28	through	through	ADP
dti-2103	302	29	activation	activation	NOUN
dti-2103	302	30	of	of	ADP
dti-2103	302	31	the	the	DET
dti-2103	302	32	p2y6	p2y6	NOUN
dti-2103	302	33	receptor	receptor	NOUN
dti-2103	302	34	.	.	PUNCT
dti-2103	303	1	j	j	PROPN
dti-2103	303	2	immunol	immunol	NOUN
dti-2103	303	3	.	.	PUNCT
dti-2103	304	1	2011;186:3701	2011;186:3701	NUM
dti-2103	304	2	-	-	SYM
dti-2103	304	3	3709	3709	NUM
dti-2103	304	4	.	.	PUNCT
dti-2103	305	1	28	28	NUM
dti-2103	305	2	.	.	PUNCT
dti-2103	306	1	cox	cox	PROPN
dti-2103	306	2	ma	ma	PROPN
dti-2103	306	3	,	,	PUNCT
dti-2103	306	4	gomes	gomes	PROPN
dti-2103	306	5	b	b	PROPN
dti-2103	306	6	,	,	PUNCT
dti-2103	306	7	palmer	palmer	PROPN
dti-2103	306	8	k	k	PROPN
dti-2103	306	9	,	,	PUNCT
dti-2103	306	10	et	et	PROPN
dti-2103	306	11	al	al	PROPN
dti-2103	306	12	.	.	PUNCT
dti-2103	307	1	the	the	DET
dti-2103	307	2	pyrimidinergic	pyrimidinergic	ADJ
dti-2103	307	3	p2y6	p2y6	NOUN
dti-2103	307	4	receptor	receptor	NOUN
dti-2103	307	5	mediates	mediate	VERB
dti-2103	307	6	a	a	DET
dti-2103	307	7	novel	novel	ADJ
dti-2103	307	8	release	release	NOUN
dti-2103	307	9	of	of	ADP
dti-2103	307	10	proinflammatory	proinflammatory	ADJ
dti-2103	307	11	cytokines	cytokine	NOUN
dti-2103	307	12	and	and	CCONJ
dti-2103	307	13	chemokines	chemokine	NOUN
dti-2103	307	14	in	in	ADP
dti-2103	307	15	monocytic	monocytic	ADJ
dti-2103	307	16	cells	cell	NOUN
dti-2103	307	17	stimulated	stimulate	VERB
dti-2103	307	18	with	with	ADP
dti-2103	307	19	udp	udp	PROPN
dti-2103	307	20	.	.	PROPN
dti-2103	307	21	biochem	biochem	PROPN
dti-2103	307	22	biophys	biophys	PROPN
dti-2103	307	23	res	re	NOUN
dti-2103	307	24	commun	commun	PROPN
dti-2103	307	25	.	.	PUNCT
dti-2103	308	1	2005;330:467	2005;330:467	X
dti-2103	308	2	-	-	SYM
dti-2103	308	3	473	473	NUM
dti-2103	308	4	.	.	NOUN
dti-2103	309	1	29	29	NUM
dti-2103	309	2	.	.	PUNCT
dti-2103	309	3	grbic	grbic	ADJ
dti-2103	309	4	dm	dm	PROPN
dti-2103	309	5	,	,	PUNCT
dti-2103	309	6	degagné	degagné	NOUN
dti-2103	309	7	é	é	NOUN
dti-2103	309	8	,	,	PUNCT
dti-2103	309	9	larrivée	larrivée	PROPN
dti-2103	309	10	jf	jf	PROPN
dti-2103	309	11	,	,	PUNCT
dti-2103	309	12	et	et	PROPN
dti-2103	309	13	al	al	PROPN
dti-2103	309	14	.	.	PUNCT
dti-2103	310	1	p2y6	p2y6	PROPN
dti-2103	310	2	receptor	receptor	NOUN
dti-2103	310	3	contributes	contribute	VERB
dti-2103	310	4	to	to	ADP
dti-2103	310	5	neutrophil	neutrophil	ADJ
dti-2103	310	6	recruitment	recruitment	NOUN
dti-2103	310	7	to	to	PART
dti-2103	310	8	inflamed	inflamed	VERB
dti-2103	310	9	intestinal	intestinal	ADJ
dti-2103	310	10	mucosa	mucosa	NOUN
dti-2103	310	11	by	by	ADP
dti-2103	310	12	increasing	increase	VERB
dti-2103	310	13	cxc	cxc	PROPN
dti-2103	310	14	chemokine	chemokine	PROPN
dti-2103	310	15	ligand	ligand	NOUN
dti-2103	310	16	8	8	NUM
dti-2103	310	17	expression	expression	NOUN
dti-2103	310	18	in	in	ADP
dti-2103	310	19	an	an	DET
dti-2103	310	20	ap1	ap1	PROPN
dti-2103	310	21	-	-	PUNCT
dti-2103	310	22	dependent	dependent	ADJ
dti-2103	310	23	manner	manner	NOUN
dti-2103	310	24	in	in	ADP
dti-2103	310	25	epithelial	epithelial	ADJ
dti-2103	310	26	cells	cell	NOUN
dti-2103	310	27	.	.	PUNCT
dti-2103	311	1	inflamm	inflamm	PROPN
dti-2103	311	2	bowel	bowel	PROPN
dti-2103	311	3	dis	dis	PROPN
dti-2103	311	4	.	.	PUNCT
dti-2103	312	1	2012;18:1456	2012;18:1456	NUM
dti-2103	312	2	-	-	SYM
dti-2103	312	3	1469	1469	NUM
dti-2103	312	4	.	.	PUNCT
dti-2103	313	1	30	30	NUM
dti-2103	313	2	.	.	PUNCT
dti-2103	314	1	ginsburg	ginsburg	PROPN
dti-2103	314	2	-	-	PUNCT
dti-2103	314	3	shmuel	shmuel	PROPN
dti-2103	314	4	t	t	PROPN
dti-2103	314	5	,	,	PUNCT
dti-2103	314	6	haas	haas	PROPN
dti-2103	314	7	m	m	PROPN
dti-2103	314	8	,	,	PUNCT
dti-2103	314	9	grbic	grbic	ADJ
dti-2103	314	10	d	d	NOUN
dti-2103	314	11	,	,	PUNCT
dti-2103	314	12	et	et	PROPN
dti-2103	314	13	al	al	PROPN
dti-2103	314	14	.	.	PROPN
dti-2103	314	15	udp	udp	PROPN
dti-2103	314	16	made	make	VERB
dti-2103	314	17	a	a	DET
dti-2103	314	18	highly	highly	ADV
dti-2103	314	19	promising	promising	ADJ
dti-2103	314	20	stable	stable	ADJ
dti-2103	314	21	,	,	PUNCT
dti-2103	314	22	potent	potent	NOUN
dti-2103	314	23	,	,	PUNCT
dti-2103	314	24	and	and	CCONJ
dti-2103	314	25	selective	selective	ADJ
dti-2103	314	26	p2y6	p2y6	NOUN
dti-2103	314	27	-	-	NOUN
dti-2103	314	28	receptor	receptor	ADJ
dti-2103	314	29	agonist	agonist	NOUN
dti-2103	314	30	upon	upon	SCONJ
dti-2103	314	31	introduction	introduction	NOUN
dti-2103	314	32	of	of	ADP
dti-2103	314	33	a	a	DET
dti-2103	314	34	boranophosphate	boranophosphate	ADJ
dti-2103	314	35	moiety	moiety	NOUN
dti-2103	314	36	.	.	PUNCT
dti-2103	315	1	bioorg	bioorg	PROPN
dti-2103	315	2	med	med	PROPN
dti-2103	315	3	chem	chem	NOUN
dti-2103	315	4	.	.	PUNCT
dti-2103	316	1	2012;20:5483	2012;20:5483	NUM
dti-2103	316	2	-	-	PUNCT
dti-2103	316	3	5495	5495	NUM
dti-2103	316	4	.	.	PUNCT
dti-2103	317	1	31	31	NUM
dti-2103	317	2	.	.	PUNCT
dti-2103	318	1	hao	hao	PROPN
dti-2103	318	2	y	y	PROPN
dti-2103	318	3	,	,	PUNCT
dti-2103	318	4	liang	liang	PROPN
dti-2103	318	5	jf	jf	PROPN
dti-2103	318	6	,	,	PUNCT
dti-2103	318	7	chow	chow	PROPN
dti-2103	318	8	w	w	PROPN
dti-2103	318	9	,	,	PUNCT
dti-2103	318	10	cheung	cheung	PROPN
dti-2103	318	11	w	w	PROPN
dti-2103	318	12	,	,	PUNCT
dti-2103	318	13	ko	ko	PROPN
dti-2103	318	14	w.	w.	PROPN
dti-2103	318	15	p2y6	p2y6	PROPN
dti-2103	318	16	receptor	receptor	NOUN
dti-2103	318	17	mediated	mediate	VERB
dti-2103	318	18	proinflammatory	proinflammatory	ADJ
dti-2103	318	19	signaling	signaling	NOUN
dti-2103	318	20	in	in	ADP
dti-2103	318	21	human	human	ADJ
dti-2103	318	22	bronchial	bronchial	ADJ
dti-2103	318	23	epithelia	epithelia	NOUN
dti-2103	318	24	.	.	PUNCT
dti-2103	319	1	plos	plos	PROPN
dti-2103	319	2	one	one	NUM
dti-2103	319	3	.	.	PUNCT
dti-2103	320	1	2014;9	2014;9	NUM
dti-2103	320	2	:	:	PUNCT
dti-2103	320	3	e106235	e106235	PROPN
dti-2103	320	4	.	.	PROPN
dti-2103	320	5	32	32	NUM
dti-2103	320	6	.	.	PUNCT
dti-2103	321	1	subramanian	subramanian	PROPN
dti-2103	321	2	k	k	PROPN
dti-2103	321	3	,	,	PUNCT
dti-2103	321	4	henriques	henrique	NOUN
dti-2103	321	5	-	-	PUNCT
dti-2103	321	6	normark	normark	ADJ
dti-2103	321	7	b	b	NOUN
dti-2103	321	8	,	,	PUNCT
dti-2103	321	9	normark	normark	PROPN
dti-2103	321	10	s.	s.	PROPN
dti-2103	321	11	emerging	emerge	VERB
dti-2103	321	12	concepts	concept	NOUN
dti-2103	321	13	in	in	ADP
dti-2103	321	14	the	the	DET
dti-2103	321	15	pathogenesis	pathogenesis	NOUN
dti-2103	321	16	of	of	ADP
dti-2103	321	17	the	the	DET
dti-2103	321	18	streptococcus	streptococcus	NOUN
dti-2103	321	19	pneumoniae	pneumoniae	ADJ
dti-2103	321	20	:	:	PUNCT
dti-2103	321	21	from	from	ADP
dti-2103	321	22	nasopharyngeal	nasopharyngeal	ADJ
dti-2103	321	23	colonizer	colonizer	NOUN
dti-2103	321	24	to	to	ADP
dti-2103	321	25	intracellular	intracellular	ADJ
dti-2103	321	26	pathogen	pathogen	NOUN
dti-2103	321	27	.	.	PUNCT
dti-2103	322	1	cell	cell	NOUN
dti-2103	322	2	microbiol	microbiol	PROPN
dti-2103	322	3	.	.	PUNCT
dti-2103	323	1	2019;2	2019;2	NUM
dti-2103	323	2	:	:	PUNCT
dti-2103	323	3	e13077	e13077	PROPN
dti-2103	323	4	.	.	PROPN
dti-2103	324	1	33	33	NUM
dti-2103	324	2	.	.	PUNCT
dti-2103	325	1	zhang	zhang	PROPN
dti-2103	325	2	z	z	PROPN
dti-2103	325	3	,	,	PUNCT
dti-2103	325	4	wang	wang	PROPN
dti-2103	325	5	z	z	PROPN
dti-2103	325	6	,	,	PUNCT
dti-2103	325	7	ren	ren	PROPN
dti-2103	325	8	h	h	NOUN
dti-2103	325	9	,	,	PUNCT
dti-2103	325	10	et	et	PROPN
dti-2103	325	11	al	al	PROPN
dti-2103	325	12	.	.	PUNCT
dti-2103	325	13	p2y6	p2y6	PROPN
dti-2103	325	14	agonist	agonist	NOUN
dti-2103	325	15	uridine	uridine	NOUN
dti-2103	325	16	5′-diphosphate	5′-diphosphate	NOUN
dti-2103	325	17	promotes	promote	VERB
dti-2103	325	18	host	host	NOUN
dti-2103	325	19	defense	defense	NOUN
dti-2103	325	20	against	against	ADP
dti-2103	325	21	bacterial	bacterial	ADJ
dti-2103	325	22	infection	infection	NOUN
dti-2103	325	23	via	via	ADP
dti-2103	325	24	monocyte	monocyte	PROPN
dti-2103	325	25	chemoattractant	chemoattractant	PROPN
dti-2103	325	26	protein-1	protein-1	PROPN
dti-2103	325	27	–	–	PUNCT
dti-2103	325	28	mediated	mediate	VERB
dti-2103	325	29	monocytes	monocyte	NOUN
dti-2103	325	30	/	/	SYM
dti-2103	325	31	macrophages	macrophage	NOUN
dti-2103	325	32	recruitment	recruitment	NOUN
dti-2103	325	33	.	.	PUNCT
dti-2103	326	1	j	j	PROPN
dti-2103	326	2	immunol	immunol	NOUN
dti-2103	326	3	.	.	PUNCT
dti-2103	327	1	2011;186	2011;186	NUM
dti-2103	327	2	:	:	PUNCT
dti-2103	327	3	5376	5376	NUM
dti-2103	327	4	-	-	SYM
dti-2103	327	5	5387	5387	NUM
dti-2103	327	6	.	.	PUNCT
dti-2103	328	1	34	34	NUM
dti-2103	328	2	.	.	PUNCT
dti-2103	329	1	idzko	idzko	PROPN
dti-2103	329	2	m	m	PROPN
dti-2103	329	3	,	,	PUNCT
dti-2103	329	4	ferrari	ferrari	PROPN
dti-2103	329	5	d	d	PROPN
dti-2103	329	6	,	,	PUNCT
dti-2103	329	7	eltzschig	eltzschig	PROPN
dti-2103	329	8	hk	hk	PROPN
dti-2103	329	9	.	.	PUNCT
dti-2103	329	10	nucleotide	nucleotide	PROPN
dti-2103	329	11	signalling	signal	VERB
dti-2103	329	12	during	during	ADP
dti-2103	329	13	inflammation	inflammation	NOUN
dti-2103	329	14	.	.	PUNCT
dti-2103	330	1	nature	nature	NOUN
dti-2103	330	2	.	.	PUNCT
dti-2103	331	1	2014;509:310	2014;509:310	NUM
dti-2103	331	2	-	-	SYM
dti-2103	331	3	317	317	NUM
dti-2103	331	4	.	.	PUNCT
dti-2103	331	5	35	35	NUM
dti-2103	331	6	.	.	PUNCT
dti-2103	332	1	koizumi	koizumi	PROPN
dti-2103	332	2	s	s	PROPN
dti-2103	332	3	,	,	PUNCT
dti-2103	332	4	shigemoto	shigemoto	NOUN
dti-2103	332	5	-	-	PUNCT
dti-2103	332	6	mogami	mogami	PROPN
dti-2103	332	7	y	y	PROPN
dti-2103	332	8	,	,	PUNCT
dti-2103	332	9	nasu	nasu	PROPN
dti-2103	332	10	-	-	PUNCT
dti-2103	332	11	tada	tada	PROPN
dti-2103	332	12	k	k	PROPN
dti-2103	332	13	,	,	PUNCT
dti-2103	332	14	et	et	PROPN
dti-2103	332	15	al	al	PROPN
dti-2103	332	16	.	.	PROPN
dti-2103	332	17	udp	udp	PROPN
dti-2103	332	18	acting	act	VERB
dti-2103	332	19	at	at	ADP
dti-2103	332	20	p2y6	p2y6	NOUN
dti-2103	332	21	receptors	receptor	NOUN
dti-2103	332	22	is	be	AUX
dti-2103	332	23	a	a	DET
dti-2103	332	24	mediator	mediator	NOUN
dti-2103	332	25	of	of	ADP
dti-2103	332	26	microglial	microglial	ADJ
dti-2103	332	27	phagocytosis	phagocytosis	NOUN
dti-2103	332	28	.	.	PUNCT
dti-2103	333	1	nature	nature	NOUN
dti-2103	333	2	.	.	PUNCT
dti-2103	334	1	2007;446:1091	2007;446:1091	NUM
dti-2103	334	2	-	-	SYM
dti-2103	334	3	1095	1095	NUM
dti-2103	334	4	.	.	PUNCT
dti-2103	335	1	36	36	NUM
dti-2103	335	2	.	.	PUNCT
dti-2103	336	1	inoue	inoue	PROPN
dti-2103	336	2	k	k	PROPN
dti-2103	336	3	,	,	PUNCT
dti-2103	336	4	koizumi	koizumi	PROPN
dti-2103	336	5	s	s	PROPN
dti-2103	336	6	,	,	PUNCT
dti-2103	336	7	kataoka	kataoka	PROPN
dti-2103	336	8	a	a	PRON
dti-2103	336	9	,	,	PUNCT
dti-2103	336	10	tozaki	tozaki	ADJ
dti-2103	336	11	-	-	PUNCT
dti-2103	336	12	saitoh	saitoh	ADJ
dti-2103	336	13	h	h	NOUN
dti-2103	336	14	,	,	PUNCT
dti-2103	336	15	tsuda	tsuda	NOUN
dti-2103	336	16	m.	m.	NOUN
dti-2103	336	17	p2y(6)-evoked	p2y(6)-evoke	VERB
dti-2103	336	18	microglial	microglial	ADJ
dti-2103	336	19	phagocytosis	phagocytosis	NOUN
dti-2103	336	20	.	.	PUNCT
dti-2103	337	1	int	int	PROPN
dti-2103	337	2	rev	rev	PROPN
dti-2103	337	3	neurobiol	neurobiol	PROPN
dti-2103	337	4	.	.	PUNCT
dti-2103	338	1	2009;85:159	2009;85:159	NUM
dti-2103	338	2	-	-	SYM
dti-2103	338	3	163	163	NUM
dti-2103	338	4	.	.	PUNCT
dti-2103	339	1	37	37	NUM
dti-2103	339	2	.	.	PUNCT
dti-2103	340	1	neher	neher	PROPN
dti-2103	340	2	jj	jj	PROPN
dti-2103	340	3	,	,	PUNCT
dti-2103	340	4	neniskyte	neniskyte	PROPN
dti-2103	340	5	u	u	NOUN
dti-2103	340	6	,	,	PUNCT
dti-2103	340	7	hornik	hornik	X
dti-2103	340	8	t	t	PROPN
dti-2103	340	9	,	,	PUNCT
dti-2103	340	10	brown	brown	PROPN
dti-2103	340	11	gc	gc	PROPN
dti-2103	340	12	.	.	PROPN
dti-2103	340	13	inhibition	inhibition	NOUN
dti-2103	340	14	of	of	ADP
dti-2103	340	15	udp	udp	NOUN
dti-2103	340	16	/	/	SYM
dti-2103	340	17	p2y6	p2y6	NOUN
dti-2103	340	18	purinergic	purinergic	NOUN
dti-2103	340	19	signaling	signal	VERB
dti-2103	340	20	prevents	prevent	VERB
dti-2103	340	21	phagocytosis	phagocytosis	NOUN
dti-2103	340	22	of	of	ADP
dti-2103	340	23	viable	viable	ADJ
dti-2103	340	24	neurons	neuron	NOUN
dti-2103	340	25	by	by	ADP
dti-2103	340	26	activated	activate	VERB
dti-2103	340	27	microglia	microglia	NOUN
dti-2103	340	28	in	in	ADP
dti-2103	340	29	vitro	vitro	X
dti-2103	340	30	and	and	CCONJ
dti-2103	340	31	in	in	ADP
dti-2103	340	32	vivo	vivo	NOUN
dti-2103	340	33	.	.	PUNCT
dti-2103	341	1	glia	glia	NOUN
dti-2103	341	2	.	.	PUNCT
dti-2103	342	1	2014;62:1463	2014;62:1463	NUM
dti-2103	342	2	-	-	SYM
dti-2103	342	3	1475	1475	NUM
dti-2103	342	4	.	.	PUNCT
dti-2103	343	1	38	38	NUM
dti-2103	343	2	.	.	PUNCT
dti-2103	343	3	zierhut	zierhut	PROPN
dti-2103	343	4	m	m	PROPN
dti-2103	343	5	,	,	PUNCT
dti-2103	343	6	dyckhoff	dyckhoff	PROPN
dti-2103	343	7	s	s	PROPN
dti-2103	343	8	,	,	PUNCT
dti-2103	343	9	masouris	masouris	PROPN
dti-2103	343	10	i	i	PROPN
dti-2103	343	11	,	,	PUNCT
dti-2103	343	12	et	et	PROPN
dti-2103	343	13	al	al	PROPN
dti-2103	343	14	.	.	PUNCT
dti-2103	343	15	role	role	NOUN
dti-2103	343	16	of	of	ADP
dti-2103	343	17	purinergic	purinergic	NOUN
dti-2103	343	18	signaling	signal	VERB
dti-2103	343	19	in	in	ADP
dti-2103	343	20	experimental	experimental	ADJ
dti-2103	343	21	pneumococcal	pneumococcal	ADJ
dti-2103	343	22	meningitis	meningitis	NOUN
dti-2103	343	23	.	.	PUNCT
dti-2103	344	1	sci	sci	PROPN
dti-2103	344	2	rep	rep	PROPN
dti-2103	344	3	.	.	PROPN
dti-2103	344	4	2017;7:44625	2017;7:44625	NUM
dti-2103	344	5	.	.	PUNCT