id	sid	tid	token	lemma	pos
dti-2469	1	1	dti	dti	PROPN
dti-2469	1	2	drug	drug	PROPN
dti-2469	1	3	target	target	NOUN
dti-2469	1	4	insights	insight	NOUN
dti-2469	1	5	issn	issn	VERB
dti-2469	1	6	1177	1177	NUM
dti-2469	1	7	-	-	SYM
dti-2469	1	8	3928	3928	NUM
dti-2469	1	9	www.aboutscience.eu/dti	www.aboutscience.eu/dti	NOUN
dti-2469	1	10	©	©	PROPN
dti-2469	1	11	2022	2022	NUM
dti-2469	1	12	the	the	DET
dti-2469	1	13	authors	author	NOUN
dti-2469	1	14	.	.	PUNCT
dti-2469	2	1	this	this	DET
dti-2469	2	2	article	article	NOUN
dti-2469	2	3	is	be	AUX
dti-2469	2	4	published	publish	VERB
dti-2469	2	5	by	by	ADP
dti-2469	2	6	aboutscience	aboutscience	NOUN
dti-2469	2	7	and	and	CCONJ
dti-2469	2	8	licensed	license	VERB
dti-2469	2	9	under	under	ADP
dti-2469	2	10	creative	creative	ADJ
dti-2469	2	11	commons	common	NOUN
dti-2469	2	12	attribution	attribution	NOUN
dti-2469	2	13	-	-	PUNCT
dti-2469	2	14	noncommercial	noncommercial	ADJ
dti-2469	2	15	4.0	4.0	NUM
dti-2469	2	16	international	international	NOUN
dti-2469	2	17	(	(	PUNCT
dti-2469	2	18	cc	cc	NOUN
dti-2469	2	19	by	by	ADP
dti-2469	2	20	-	-	PUNCT
dti-2469	2	21	nc	nc	PROPN
dti-2469	2	22	4.0	4.0	NUM
dti-2469	2	23	)	)	PUNCT
dti-2469	2	24	.	.	PUNCT
dti-2469	3	1	commercial	commercial	ADJ
dti-2469	3	2	use	use	NOUN
dti-2469	3	3	is	be	AUX
dti-2469	3	4	not	not	PART
dti-2469	3	5	permitted	permit	VERB
dti-2469	3	6	and	and	CCONJ
dti-2469	3	7	is	be	AUX
dti-2469	3	8	subject	subject	ADJ
dti-2469	3	9	to	to	ADP
dti-2469	3	10	publisher	publisher	NOUN
dti-2469	3	11	’s	’s	PART
dti-2469	3	12	permissions	permission	NOUN
dti-2469	3	13	.	.	PUNCT
dti-2469	4	1	full	full	ADJ
dti-2469	4	2	information	information	NOUN
dti-2469	4	3	is	be	AUX
dti-2469	4	4	available	available	ADJ
dti-2469	4	5	at	at	ADP
dti-2469	4	6	www.aboutscience.eu	www.aboutscience.eu	PROPN
dti-2469	4	7	drug	drug	NOUN
dti-2469	4	8	target	target	NOUN
dti-2469	4	9	insights	insight	NOUN
dti-2469	4	10	2022	2022	NUM
dti-2469	4	11	;	;	PUNCT
dti-2469	4	12	16	16	NUM
dti-2469	4	13	:	:	SYM
dti-2469	4	14	17	17	NUM
dti-2469	4	15	-	-	SYM
dti-2469	4	16	24	24	NUM
dti-2469	4	17	issn	issn	PROPN
dti-2469	4	18	1177	1177	NUM
dti-2469	4	19	-	-	SYM
dti-2469	4	20	3928	3928	NUM
dti-2469	4	21	|	|	ADV
dti-2469	4	22	doi	doi	NOUN
dti-2469	4	23	:	:	PUNCT
dti-2469	4	24	10.33393	10.33393	NUM
dti-2469	4	25	/	/	SYM
dti-2469	4	26	dti.2022.2469	dti.2022.2469	NOUN
dti-2469	4	27	original	original	ADJ
dti-2469	4	28	research	research	NOUN
dti-2469	4	29	article	article	NOUN
dti-2469	4	30	redefining	redefine	VERB
dti-2469	4	31	genomic	genomic	ADJ
dti-2469	4	32	view	view	NOUN
dti-2469	4	33	of	of	ADP
dti-2469	4	34	clostridioides	clostridioide	NOUN
dti-2469	4	35	difficile	difficile	VERB
dti-2469	4	36	through	through	ADP
dti-2469	4	37	pangenome	pangenome	NOUN
dti-2469	4	38	analysis	analysis	NOUN
dti-2469	4	39	and	and	CCONJ
dti-2469	4	40	identification	identification	NOUN
dti-2469	4	41	of	of	ADP
dti-2469	4	42	drug	drug	NOUN
dti-2469	4	43	targets	target	NOUN
dti-2469	4	44	from	from	ADP
dti-2469	4	45	its	its	PRON
dti-2469	4	46	core	core	NOUN
dti-2469	4	47	genome	genome	NOUN
dti-2469	4	48	nikita	nikita	X
dti-2469	4	49	chordia	chordia	PROPN
dti-2469	4	50	golchha1	golchha1	PROPN
dti-2469	4	51	,	,	PUNCT
dti-2469	4	52	anand	anand	PROPN
dti-2469	4	53	nighojkar2	nighojkar2	PROPN
dti-2469	4	54	,	,	PUNCT
dti-2469	4	55	sadhana	sadhana	NOUN
dti-2469	4	56	nighojkar3	nighojkar3	NOUN
dti-2469	4	57	1school	1school	NUM
dti-2469	4	58	of	of	ADP
dti-2469	4	59	biotechnology	biotechnology	NOUN
dti-2469	4	60	,	,	PUNCT
dti-2469	4	61	devi	devi	PROPN
dti-2469	4	62	ahilya	ahilya	PROPN
dti-2469	4	63	university	university	PROPN
dti-2469	4	64	,	,	PUNCT
dti-2469	4	65	takshashila	takshashila	PROPN
dti-2469	4	66	campus	campus	PROPN
dti-2469	4	67	,	,	PUNCT
dti-2469	4	68	indore	indore	PROPN
dti-2469	4	69	india	india	PROPN
dti-2469	4	70	2maharaja	2maharaja	PROPN
dti-2469	4	71	ranjit	ranjit	PROPN
dti-2469	4	72	singh	singh	PROPN
dti-2469	4	73	college	college	PROPN
dti-2469	4	74	of	of	ADP
dti-2469	4	75	professional	professional	PROPN
dti-2469	4	76	sciences	sciences	PROPN
dti-2469	4	77	,	,	PUNCT
dti-2469	4	78	hemkunt	hemkunt	PROPN
dti-2469	4	79	campus	campus	PROPN
dti-2469	4	80	,	,	PUNCT
dti-2469	4	81	indore	indore	PROPN
dti-2469	4	82	india	india	PROPN
dti-2469	4	83	3mata	3mata	NUM
dti-2469	4	84	gujri	gujri	PROPN
dti-2469	4	85	college	college	NOUN
dti-2469	4	86	of	of	ADP
dti-2469	4	87	professional	professional	ADJ
dti-2469	4	88	studies	study	NOUN
dti-2469	4	89	,	,	PUNCT
dti-2469	4	90	indore	indore	PROPN
dti-2469	4	91	india	india	PROPN
dti-2469	4	92	abstract	abstract	ADJ
dti-2469	4	93	introduction	introduction	NOUN
dti-2469	4	94	:	:	PUNCT
dti-2469	4	95	clostridioides	clostridioide	NOUN
dti-2469	4	96	difficile	difficile	VERB
dti-2469	4	97	infection	infection	NOUN
dti-2469	4	98	(	(	PUNCT
dti-2469	4	99	cdi	cdi	PROPN
dti-2469	4	100	)	)	PUNCT
dti-2469	4	101	is	be	AUX
dti-2469	4	102	a	a	DET
dti-2469	4	103	leading	lead	VERB
dti-2469	4	104	cause	cause	NOUN
dti-2469	4	105	of	of	ADP
dti-2469	4	106	gastrointestinal	gastrointestinal	ADJ
dti-2469	4	107	infections	infection	NOUN
dti-2469	4	108	and	and	CCONJ
dti-2469	4	109	in	in	ADP
dti-2469	4	110	the	the	DET
dti-2469	4	111	present	present	ADJ
dti-2469	4	112	day	day	NOUN
dti-2469	4	113	is	be	AUX
dti-2469	4	114	a	a	DET
dti-2469	4	115	major	major	ADJ
dti-2469	4	116	concern	concern	NOUN
dti-2469	4	117	for	for	ADP
dti-2469	4	118	global	global	ADJ
dti-2469	4	119	health	health	NOUN
dti-2469	4	120	care	care	NOUN
dti-2469	4	121	system	system	NOUN
dti-2469	4	122	.	.	PUNCT
dti-2469	5	1	the	the	DET
dti-2469	5	2	unavailability	unavailability	NOUN
dti-2469	5	3	of	of	ADP
dti-2469	5	4	specific	specific	ADJ
dti-2469	5	5	antibiotics	antibiotic	NOUN
dti-2469	5	6	for	for	ADP
dti-2469	5	7	cdi	cdi	PROPN
dti-2469	5	8	treatment	treatment	NOUN
dti-2469	5	9	and	and	CCONJ
dti-2469	5	10	its	its	PRON
dti-2469	5	11	emerging	emerge	VERB
dti-2469	5	12	cases	case	NOUN
dti-2469	5	13	worldwide	worldwide	ADV
dti-2469	5	14	further	far	ADV
dti-2469	5	15	broaden	broaden	VERB
dti-2469	5	16	the	the	DET
dti-2469	5	17	challenge	challenge	NOUN
dti-2469	5	18	to	to	PART
dti-2469	5	19	control	control	VERB
dti-2469	5	20	cdi	cdi	PROPN
dti-2469	5	21	.	.	PROPN
dti-2469	5	22	methods	method	NOUN
dti-2469	5	23	:	:	PUNCT
dti-2469	5	24	the	the	DET
dti-2469	5	25	availability	availability	NOUN
dti-2469	5	26	of	of	ADP
dti-2469	5	27	a	a	DET
dti-2469	5	28	large	large	ADJ
dti-2469	5	29	number	number	NOUN
dti-2469	5	30	of	of	ADP
dti-2469	5	31	genome	genome	NOUN
dti-2469	5	32	sequences	sequence	NOUN
dti-2469	5	33	for	for	ADP
dti-2469	5	34	c.	c.	NOUN
dti-2469	5	35	difficile	difficile	NOUN
dti-2469	5	36	and	and	CCONJ
dti-2469	5	37	many	many	ADJ
dti-2469	5	38	bioinformatics	bioinformatics	NOUN
dti-2469	5	39	tools	tool	NOUN
dti-2469	5	40	for	for	ADP
dti-2469	5	41	genome	genome	NOUN
dti-2469	5	42	analysis	analysis	NOUN
dti-2469	5	43	provides	provide	VERB
dti-2469	5	44	the	the	DET
dti-2469	5	45	opportunity	opportunity	NOUN
dti-2469	5	46	for	for	ADP
dti-2469	5	47	in	in	ADP
dti-2469	5	48	silico	silico	NOUN
dti-2469	5	49	pangenomic	pangenomic	ADJ
dti-2469	5	50	analysis	analysis	NOUN
dti-2469	5	51	.	.	PUNCT
dti-2469	6	1	in	in	ADP
dti-2469	6	2	the	the	DET
dti-2469	6	3	present	present	ADJ
dti-2469	6	4	study	study	NOUN
dti-2469	6	5	,	,	PUNCT
dti-2469	6	6	97	97	NUM
dti-2469	6	7	strains	strain	NOUN
dti-2469	6	8	of	of	ADP
dti-2469	6	9	c.	c.	NOUN
dti-2469	6	10	difficile	difficile	PROPN
dti-2469	6	11	were	be	AUX
dti-2469	6	12	used	use	VERB
dti-2469	6	13	for	for	ADP
dti-2469	6	14	pangenomic	pangenomic	ADJ
dti-2469	6	15	studies	study	NOUN
dti-2469	6	16	and	and	CCONJ
dti-2469	6	17	characterized	characterize	VERB
dti-2469	6	18	for	for	ADP
dti-2469	6	19	their	their	PRON
dti-2469	6	20	phylogenomic	phylogenomic	ADJ
dti-2469	6	21	and	and	CCONJ
dti-2469	6	22	functional	functional	ADJ
dti-2469	6	23	analysis	analysis	NOUN
dti-2469	6	24	.	.	PUNCT
dti-2469	7	1	results	result	NOUN
dti-2469	7	2	:	:	PUNCT
dti-2469	7	3	pangenome	pangenome	NOUN
dti-2469	7	4	analysis	analysis	NOUN
dti-2469	7	5	reveals	reveal	VERB
dti-2469	7	6	open	open	ADJ
dti-2469	7	7	pangenome	pangenome	NOUN
dti-2469	7	8	of	of	ADP
dti-2469	7	9	c.	c.	NOUN
dti-2469	7	10	difficile	difficile	NOUN
dti-2469	7	11	and	and	CCONJ
dti-2469	7	12	high	high	ADJ
dti-2469	7	13	genetic	genetic	ADJ
dti-2469	7	14	diversity	diversity	NOUN
dti-2469	7	15	.	.	PUNCT
dti-2469	8	1	sequence	sequence	NOUN
dti-2469	8	2	and	and	CCONJ
dti-2469	8	3	interactome	interactome	NOUN
dti-2469	8	4	analysis	analysis	NOUN
dti-2469	8	5	of	of	ADP
dti-2469	8	6	1,481	1,481	NUM
dti-2469	8	7	core	core	NOUN
dti-2469	8	8	genes	gene	NOUN
dti-2469	8	9	was	be	AUX
dti-2469	8	10	done	do	VERB
dti-2469	8	11	and	and	CCONJ
dti-2469	8	12	eight	eight	NUM
dti-2469	8	13	potent	potent	ADJ
dti-2469	8	14	drug	drug	NOUN
dti-2469	8	15	targets	target	NOUN
dti-2469	8	16	are	be	AUX
dti-2469	8	17	identified	identify	VERB
dti-2469	8	18	.	.	PUNCT
dti-2469	9	1	three	three	NUM
dti-2469	9	2	drug	drug	NOUN
dti-2469	9	3	targets	target	NOUN
dti-2469	9	4	,	,	PUNCT
dti-2469	9	5	namely	namely	ADV
dti-2469	9	6	,	,	PUNCT
dti-2469	9	7	aminodeoxychorismate	aminodeoxychorismate	ADJ
dti-2469	9	8	synthase	synthase	NOUN
dti-2469	9	9	(	(	PUNCT
dti-2469	9	10	pabb	pabb	NOUN
dti-2469	9	11	)	)	PUNCT
dti-2469	9	12	,	,	PUNCT
dti-2469	9	13	d	d	X
dti-2469	9	14	-	-	PUNCT
dti-2469	9	15	alanyl	alanyl	VERB
dti-2469	9	16	-	-	PUNCT
dti-2469	9	17	d	d	NOUN
dti-2469	9	18	-	-	PUNCT
dti-2469	9	19	alanine	alanine	NOUN
dti-2469	9	20	carboxypeptidase	carboxypeptidase	NOUN
dti-2469	9	21	(	(	PUNCT
dti-2469	9	22	dd	dd	NOUN
dti-2469	9	23	-	-	PUNCT
dti-2469	9	24	cpase	cpase	NOUN
dti-2469	9	25	)	)	PUNCT
dti-2469	9	26	and	and	CCONJ
dti-2469	9	27	undecaprenyl	undecaprenyl	NOUN
dti-2469	9	28	diphospho	diphospho	NOUN
dti-2469	9	29	-	-	PUNCT
dti-2469	9	30	muramoyl	muramoyl	ADJ
dti-2469	9	31	pentapeptide	pentapeptide	NOUN
dti-2469	9	32	beta	beta	NOUN
dti-2469	9	33	-	-	PUNCT
dti-2469	9	34	n	n	CCONJ
dti-2469	9	35	-	-	PUNCT
dti-2469	9	36	acetylglucosaminyl	acetylglucosaminyl	NOUN
dti-2469	9	37	transferase	transferase	NOUN
dti-2469	9	38	(	(	PUNCT
dti-2469	9	39	murg	murg	NOUN
dti-2469	9	40	transferase	transferase	NOUN
dti-2469	9	41	)	)	PUNCT
dti-2469	9	42	,	,	PUNCT
dti-2469	9	43	have	have	AUX
dti-2469	9	44	been	be	AUX
dti-2469	9	45	reported	report	VERB
dti-2469	9	46	as	as	ADP
dti-2469	9	47	drug	drug	NOUN
dti-2469	9	48	targets	target	NOUN
dti-2469	9	49	for	for	ADP
dti-2469	9	50	other	other	ADJ
dti-2469	9	51	human	human	ADJ
dti-2469	9	52	pathogens	pathogen	NOUN
dti-2469	9	53	,	,	PUNCT
dti-2469	9	54	and	and	CCONJ
dti-2469	9	55	five	five	NUM
dti-2469	9	56	targets	target	NOUN
dti-2469	9	57	,	,	PUNCT
dti-2469	9	58	namely	namely	ADV
dti-2469	9	59	,	,	PUNCT
dti-2469	9	60	bifunctional	bifunctional	ADJ
dti-2469	9	61	diguanylate	diguanylate	NOUN
dti-2469	9	62	cyclase	cyclase	NOUN
dti-2469	9	63	/	/	SYM
dti-2469	9	64	phosphodiesterase	phosphodiesterase	NOUN
dti-2469	9	65	(	(	PUNCT
dti-2469	9	66	cyclic	cyclic	NOUN
dti-2469	9	67	-	-	PUNCT
dti-2469	9	68	digmp	digmp	NOUN
dti-2469	9	69	)	)	PUNCT
dti-2469	9	70	,	,	PUNCT
dti-2469	9	71	sporulation	sporulation	NOUN
dti-2469	9	72	transcription	transcription	NOUN
dti-2469	9	73	factor	factor	NOUN
dti-2469	9	74	(	(	PUNCT
dti-2469	9	75	spo0a	spo0a	PROPN
dti-2469	9	76	)	)	PUNCT
dti-2469	9	77	,	,	PUNCT
dti-2469	9	78	histidinol	histidinol	ADJ
dti-2469	9	79	-	-	PUNCT
dti-2469	9	80	phosphate	phosphate	NOUN
dti-2469	9	81	transaminase	transaminase	NOUN
dti-2469	9	82	(	(	PUNCT
dti-2469	9	83	hisc	hisc	NOUN
dti-2469	9	84	)	)	PUNCT
dti-2469	9	85	,	,	PUNCT
dti-2469	9	86	3	3	NUM
dti-2469	9	87	-	-	PUNCT
dti-2469	9	88	deoxy-7	deoxy-7	NOUN
dti-2469	9	89	-	-	PUNCT
dti-2469	9	90	phosphoheptulonate	phosphoheptulonate	ADJ
dti-2469	9	91	synthase	synthase	NOUN
dti-2469	9	92	(	(	PUNCT
dti-2469	9	93	dahp	dahp	NOUN
dti-2469	9	94	synthase	synthase	NOUN
dti-2469	9	95	)	)	PUNCT
dti-2469	9	96	and	and	CCONJ
dti-2469	9	97	c	c	X
dti-2469	9	98	-	-	PUNCT
dti-2469	9	99	di	di	NOUN
dti-2469	9	100	-	-	PUNCT
dti-2469	9	101	gmp	gmp	NOUN
dti-2469	9	102	phosphodiesterase	phosphodiesterase	NOUN
dti-2469	9	103	(	(	PUNCT
dti-2469	9	104	pdca	pdca	PROPN
dti-2469	9	105	)	)	PUNCT
dti-2469	9	106	,	,	PUNCT
dti-2469	9	107	are	be	AUX
dti-2469	9	108	novel	novel	ADJ
dti-2469	9	109	.	.	PUNCT
dti-2469	10	1	conclusion	conclusion	NOUN
dti-2469	10	2	:	:	PUNCT
dti-2469	10	3	the	the	DET
dti-2469	10	4	suggested	suggest	VERB
dti-2469	10	5	potent	potent	ADJ
dti-2469	10	6	targets	target	NOUN
dti-2469	10	7	could	could	AUX
dti-2469	10	8	act	act	VERB
dti-2469	10	9	as	as	ADP
dti-2469	10	10	broad	broad	ADJ
dti-2469	10	11	-	-	PUNCT
dti-2469	10	12	spectrum	spectrum	NOUN
dti-2469	10	13	drug	drug	NOUN
dti-2469	10	14	targets	target	NOUN
dti-2469	10	15	for	for	ADP
dti-2469	10	16	c.	c.	PROPN
dti-2469	10	17	difficile	difficile	PROPN
dti-2469	10	18	.	.	PUNCT
dti-2469	11	1	however	however	ADV
dti-2469	11	2	,	,	PUNCT
dti-2469	11	3	further	further	ADJ
dti-2469	11	4	validation	validation	NOUN
dti-2469	11	5	needs	need	VERB
dti-2469	11	6	to	to	PART
dti-2469	11	7	be	be	AUX
dti-2469	11	8	done	do	VERB
dti-2469	11	9	before	before	ADP
dti-2469	11	10	using	use	VERB
dti-2469	11	11	them	they	PRON
dti-2469	11	12	for	for	ADP
dti-2469	11	13	lead	lead	ADJ
dti-2469	11	14	compound	compound	NOUN
dti-2469	11	15	discovery	discovery	NOUN
dti-2469	11	16	.	.	PUNCT
dti-2469	12	1	keywords	keyword	NOUN
dti-2469	12	2	:	:	PUNCT
dti-2469	12	3	clostridioides	clostridioide	NOUN
dti-2469	12	4	difficile	difficile	ADJ
dti-2469	12	5	,	,	PUNCT
dti-2469	12	6	drug	drug	NOUN
dti-2469	12	7	target	target	NOUN
dti-2469	12	8	,	,	PUNCT
dti-2469	12	9	genome	genome	NOUN
dti-2469	12	10	,	,	PUNCT
dti-2469	12	11	inhibition	inhibition	NOUN
dti-2469	12	12	,	,	PUNCT
dti-2469	12	13	phylogenomics	phylogenomic	NOUN
dti-2469	12	14	received	receive	VERB
dti-2469	12	15	:	:	PUNCT
dti-2469	12	16	july	july	PROPN
dti-2469	12	17	16	16	NUM
dti-2469	12	18	,	,	PUNCT
dti-2469	12	19	2022	2022	NUM
dti-2469	12	20	accepted	accept	VERB
dti-2469	12	21	:	:	PUNCT
dti-2469	12	22	october	october	PROPN
dti-2469	12	23	10	10	NUM
dti-2469	12	24	,	,	PUNCT
dti-2469	12	25	2022	2022	NUM
dti-2469	12	26	published	publish	VERB
dti-2469	12	27	online	online	ADV
dti-2469	12	28	:	:	PUNCT
dti-2469	12	29	november	november	PROPN
dti-2469	12	30	11	11	NUM
dti-2469	12	31	,	,	PUNCT
dti-2469	12	32	2022	2022	NUM
dti-2469	12	33	this	this	DET
dti-2469	12	34	article	article	NOUN
dti-2469	12	35	includes	include	VERB
dti-2469	12	36	supplementary	supplementary	ADJ
dti-2469	12	37	material	material	NOUN
dti-2469	12	38	corresponding	corresponding	ADJ
dti-2469	12	39	author	author	NOUN
dti-2469	12	40	:	:	PUNCT
dti-2469	12	41	dr	dr	PROPN
dti-2469	12	42	.	.	PROPN
dti-2469	12	43	sadhana	sadhana	PROPN
dti-2469	12	44	nighojkar	nighojkar	PROPN
dti-2469	12	45	professor	professor	NOUN
dti-2469	12	46	and	and	CCONJ
dti-2469	12	47	head	head	NOUN
dti-2469	12	48	,	,	PUNCT
dti-2469	12	49	department	department	PROPN
dti-2469	12	50	of	of	ADP
dti-2469	12	51	biosciences	biosciences	PROPN
dti-2469	12	52	mata	mata	PROPN
dti-2469	12	53	gujri	gujri	PROPN
dti-2469	12	54	college	college	PROPN
dti-2469	12	55	of	of	ADP
dti-2469	12	56	professional	professional	ADJ
dti-2469	12	57	studies	study	NOUN
dti-2469	12	58	a.b	a.b	PROPN
dti-2469	12	59	.	.	PROPN
dti-2469	12	60	road	road	PROPN
dti-2469	12	61	brts	brts	PROPN
dti-2469	12	62	indore	indore	PROPN
dti-2469	12	63	,	,	PUNCT
dti-2469	12	64	452001	452001	NUM
dti-2469	12	65	india	india	NOUN
dti-2469	12	66	sadhana0301@gmail.com	sadhana0301@gmail.com	X
dti-2469	12	67	intestinal	intestinal	ADJ
dti-2469	12	68	epithelia	epithelia	PROPN
dti-2469	12	69	,	,	PUNCT
dti-2469	12	70	resulting	result	VERB
dti-2469	12	71	in	in	ADP
dti-2469	12	72	a	a	DET
dti-2469	12	73	variety	variety	NOUN
dti-2469	12	74	of	of	ADP
dti-2469	12	75	diseases	disease	NOUN
dti-2469	12	76	ranging	range	VERB
dti-2469	12	77	from	from	ADP
dti-2469	12	78	mild	mild	ADJ
dti-2469	12	79	,	,	PUNCT
dti-2469	12	80	self	self	NOUN
dti-2469	12	81	-	-	PUNCT
dti-2469	12	82	limiting	limit	VERB
dti-2469	12	83	diarrhoea	diarrhoea	NOUN
dti-2469	12	84	to	to	ADP
dti-2469	12	85	the	the	DET
dti-2469	12	86	fatal	fatal	ADJ
dti-2469	12	87	pseudomembranous	pseudomembranous	ADJ
dti-2469	12	88	colitis	colitis	NOUN
dti-2469	12	89	(	(	PUNCT
dti-2469	12	90	pmc	pmc	PROPN
dti-2469	12	91	)	)	PUNCT
dti-2469	12	92	(	(	PUNCT
dti-2469	12	93	2	2	NUM
dti-2469	12	94	-	-	SYM
dti-2469	12	95	5	5	NUM
dti-2469	12	96	)	)	PUNCT
dti-2469	12	97	.	.	PUNCT
dti-2469	13	1	during	during	ADP
dti-2469	13	2	the	the	DET
dti-2469	13	3	past	past	ADJ
dti-2469	13	4	two	two	NUM
dti-2469	13	5	decades	decade	NOUN
dti-2469	13	6	,	,	PUNCT
dti-2469	13	7	there	there	PRON
dti-2469	13	8	has	have	AUX
dti-2469	13	9	been	be	AUX
dti-2469	13	10	dramatic	dramatic	ADJ
dti-2469	13	11	increase	increase	NOUN
dti-2469	13	12	in	in	ADP
dti-2469	13	13	the	the	DET
dti-2469	13	14	incidence	incidence	NOUN
dti-2469	13	15	and	and	CCONJ
dti-2469	13	16	severity	severity	NOUN
dti-2469	13	17	of	of	ADP
dti-2469	13	18	c.	c.	NOUN
dti-2469	13	19	difficile	difficile	PROPN
dti-2469	13	20	infection	infection	NOUN
dti-2469	13	21	(	(	PUNCT
dti-2469	13	22	cdi	cdi	PROPN
dti-2469	13	23	)	)	PUNCT
dti-2469	13	24	(	(	PUNCT
dti-2469	13	25	6,7	6,7	NUM
dti-2469	13	26	)	)	PUNCT
dti-2469	13	27	.	.	PUNCT
dti-2469	14	1	cdi	cdi	PROPN
dti-2469	14	2	is	be	AUX
dti-2469	14	3	usually	usually	ADV
dti-2469	14	4	followed	follow	VERB
dti-2469	14	5	by	by	ADP
dti-2469	14	6	the	the	DET
dti-2469	14	7	antibiotic	antibiotic	ADJ
dti-2469	14	8	treatment	treatment	NOUN
dti-2469	14	9	that	that	PRON
dti-2469	14	10	impairs	impair	VERB
dti-2469	14	11	the	the	DET
dti-2469	14	12	protective	protective	ADJ
dti-2469	14	13	gut	gut	NOUN
dti-2469	14	14	microflora	microflora	NOUN
dti-2469	14	15	(	(	PUNCT
dti-2469	14	16	8)	8)	NUM
dti-2469	14	17	.	.	PUNCT
dti-2469	15	1	c.	c.	PROPN
dti-2469	15	2	difficile	difficile	PROPN
dti-2469	15	3	was	be	AUX
dti-2469	15	4	first	first	ADV
dti-2469	15	5	identified	identify	VERB
dti-2469	15	6	from	from	ADP
dti-2469	15	7	microbial	microbial	ADJ
dti-2469	15	8	flora	flora	NOUN
dti-2469	15	9	of	of	ADP
dti-2469	15	10	faeces	faece	NOUN
dti-2469	15	11	of	of	ADP
dti-2469	15	12	healthy	healthy	ADJ
dti-2469	15	13	newborn	newborn	ADJ
dti-2469	15	14	infants	infant	NOUN
dti-2469	15	15	and	and	CCONJ
dti-2469	15	16	was	be	AUX
dti-2469	15	17	considered	consider	VERB
dti-2469	15	18	that	that	SCONJ
dti-2469	15	19	it	it	PRON
dti-2469	15	20	has	have	VERB
dti-2469	15	21	no	no	DET
dti-2469	15	22	deleterious	deleterious	ADJ
dti-2469	15	23	effects	effect	NOUN
dti-2469	15	24	in	in	ADP
dti-2469	15	25	human	human	ADJ
dti-2469	15	26	(	(	PUNCT
dti-2469	15	27	9	9	NUM
dti-2469	15	28	)	)	PUNCT
dti-2469	15	29	.	.	PUNCT
dti-2469	16	1	but	but	CCONJ
dti-2469	16	2	later	later	ADV
dti-2469	16	3	on	on	ADV
dti-2469	16	4	,	,	PUNCT
dti-2469	16	5	it	it	PRON
dti-2469	16	6	was	be	AUX
dti-2469	16	7	identified	identify	VERB
dti-2469	16	8	as	as	ADP
dti-2469	16	9	the	the	DET
dti-2469	16	10	cause	cause	NOUN
dti-2469	16	11	of	of	ADP
dti-2469	16	12	antibiotic	antibiotic	NOUN
dti-2469	16	13	-	-	PUNCT
dti-2469	16	14	associated	associate	VERB
dti-2469	16	15	pmc	pmc	PROPN
dti-2469	16	16	(	(	PUNCT
dti-2469	16	17	10	10	NUM
dti-2469	16	18	)	)	PUNCT
dti-2469	16	19	.	.	PUNCT
dti-2469	17	1	c.	c.	PROPN
dti-2469	17	2	difficile	difficile	PROPN
dti-2469	17	3	has	have	AUX
dti-2469	17	4	been	be	AUX
dti-2469	17	5	reported	report	VERB
dti-2469	17	6	to	to	PART
dti-2469	17	7	have	have	VERB
dti-2469	17	8	genetic	genetic	ADJ
dti-2469	17	9	heterogeneity	heterogeneity	NOUN
dti-2469	17	10	because	because	SCONJ
dti-2469	17	11	of	of	ADP
dti-2469	17	12	its	its	PRON
dti-2469	17	13	wide	wide	ADJ
dti-2469	17	14	ecological	ecological	ADJ
dti-2469	17	15	adaptability	adaptability	NOUN
dti-2469	17	16	.	.	PUNCT
dti-2469	18	1	hence	hence	ADV
dti-2469	18	2	,	,	PUNCT
dti-2469	18	3	in	in	ADP
dti-2469	18	4	the	the	DET
dti-2469	18	5	past	past	ADJ
dti-2469	18	6	20	20	NUM
dti-2469	18	7	years	year	NOUN
dti-2469	18	8	,	,	PUNCT
dti-2469	18	9	significant	significant	ADJ
dti-2469	18	10	changes	change	NOUN
dti-2469	18	11	in	in	ADP
dti-2469	18	12	cdi	cdi	PROPN
dti-2469	18	13	epidemiology	epidemiology	NOUN
dti-2469	18	14	have	have	AUX
dti-2469	18	15	been	be	AUX
dti-2469	18	16	reported	report	VERB
dti-2469	18	17	(	(	PUNCT
dti-2469	18	18	11	11	NUM
dti-2469	18	19	)	)	PUNCT
dti-2469	18	20	.	.	PUNCT
dti-2469	19	1	the	the	DET
dti-2469	19	2	differences	difference	NOUN
dti-2469	19	3	in	in	ADP
dti-2469	19	4	the	the	DET
dti-2469	19	5	severity	severity	NOUN
dti-2469	19	6	of	of	ADP
dti-2469	19	7	the	the	DET
dti-2469	19	8	infection	infection	NOUN
dti-2469	19	9	,	,	PUNCT
dti-2469	19	10	presence	presence	NOUN
dti-2469	19	11	of	of	ADP
dti-2469	19	12	pathogen	pathogen	NOUN
dti-2469	19	13	at	at	ADP
dti-2469	19	14	multiple	multiple	ADJ
dti-2469	19	15	sites	site	NOUN
dti-2469	19	16	(	(	PUNCT
dti-2469	19	17	human	human	NOUN
dti-2469	19	18	,	,	PUNCT
dti-2469	19	19	animal	animal	NOUN
dti-2469	19	20	and	and	CCONJ
dti-2469	19	21	environment	environment	NOUN
dti-2469	19	22	)	)	PUNCT
dti-2469	19	23	and	and	CCONJ
dti-2469	19	24	their	their	PRON
dti-2469	19	25	genetic	genetic	ADJ
dti-2469	19	26	differences	difference	NOUN
dti-2469	19	27	have	have	AUX
dti-2469	19	28	revived	revive	VERB
dti-2469	19	29	interest	interest	NOUN
dti-2469	19	30	in	in	ADP
dti-2469	19	31	the	the	DET
dti-2469	19	32	genomic	genomic	ADJ
dti-2469	19	33	comparison	comparison	NOUN
dti-2469	19	34	of	of	ADP
dti-2469	19	35	c.	c.	PROPN
dti-2469	19	36	difficile	difficile	PROPN
dti-2469	19	37	.	.	PUNCT
dti-2469	20	1	introduction	introduction	NOUN
dti-2469	20	2	clostridioides	clostridioide	NOUN
dti-2469	20	3	difficile	difficile	VERB
dti-2469	20	4	,	,	PUNCT
dti-2469	20	5	earlier	early	ADV
dti-2469	20	6	known	know	VERB
dti-2469	20	7	as	as	ADP
dti-2469	20	8	clostridium	clostridium	NOUN
dti-2469	20	9	difficile	difficile	NOUN
dti-2469	20	10	,	,	PUNCT
dti-2469	20	11	is	be	AUX
dti-2469	20	12	a	a	DET
dti-2469	20	13	toxin	toxin	NOUN
dti-2469	20	14	-	-	PUNCT
dti-2469	20	15	producing	produce	VERB
dti-2469	20	16	gram	gram	NOUN
dti-2469	20	17	-	-	PUNCT
dti-2469	20	18	positive	positive	ADJ
dti-2469	20	19	,	,	PUNCT
dti-2469	20	20	anaerobic	anaerobic	ADJ
dti-2469	20	21	bacteria	bacteria	NOUN
dti-2469	20	22	(	(	PUNCT
dti-2469	20	23	1	1	NUM
dti-2469	20	24	)	)	PUNCT
dti-2469	20	25	.	.	PUNCT
dti-2469	21	1	during	during	ADP
dti-2469	21	2	infection	infection	NOUN
dti-2469	21	3	,	,	PUNCT
dti-2469	21	4	it	it	PRON
dti-2469	21	5	releases	release	VERB
dti-2469	21	6	toxins	toxin	NOUN
dti-2469	21	7	that	that	PRON
dti-2469	21	8	disrupt	disrupt	VERB
dti-2469	21	9	the	the	DET
dti-2469	21	10	focus	focus	NOUN
dti-2469	21	11	on	on	ADP
dti-2469	21	12	antimicrobial	antimicrobial	ADJ
dti-2469	21	13	resistance	resistance	NOUN
dti-2469	21	14	(	(	PUNCT
dti-2469	21	15	amr	amr	NOUN
dti-2469	21	16	)	)	PUNCT
dti-2469	21	17	https://creativecommons.org/licenses/by-nc/4.0/legalcode	https://creativecommons.org/licenses/by-nc/4.0/legalcode	PROPN
dti-2469	21	18	https://doi.org/10.33393/dti.2022.2469	https://doi.org/10.33393/dti.2022.2469	NOUN
dti-2469	21	19	mailto:sadhana0301@gmail.com	mailto:sadhana0301@gmail.com	PROPN
dti-2469	21	20	pangenome	pangenome	NOUN
dti-2469	21	21	analysis	analysis	NOUN
dti-2469	21	22	of	of	ADP
dti-2469	21	23	c.	c.	NOUN
dti-2469	21	24	difficile	difficile	NOUN
dti-2469	21	25	and	and	CCONJ
dti-2469	21	26	drug	drug	NOUN
dti-2469	21	27	target	target	NOUN
dti-2469	21	28	identification18	identification18	NOUN
dti-2469	22	1	©	©	ADP
dti-2469	22	2	2022	2022	NUM
dti-2469	22	3	the	the	DET
dti-2469	22	4	authors	author	NOUN
dti-2469	22	5	.	.	PUNCT
dti-2469	23	1	drug	drug	NOUN
dti-2469	23	2	target	target	NOUN
dti-2469	23	3	insights	insight	NOUN
dti-2469	23	4	issn	issn	VERB
dti-2469	23	5	1177	1177	NUM
dti-2469	23	6	-	-	SYM
dti-2469	23	7	3928	3928	NUM
dti-2469	23	8	www.aboutscience.eu/dti	www.aboutscience.eu/dti	VERB
dti-2469	23	9	several	several	ADJ
dti-2469	23	10	strains	strain	NOUN
dti-2469	23	11	of	of	ADP
dti-2469	23	12	c.	c.	NOUN
dti-2469	23	13	difficile	difficile	PROPN
dti-2469	23	14	have	have	AUX
dti-2469	23	15	been	be	AUX
dti-2469	23	16	isolated	isolate	VERB
dti-2469	23	17	and	and	CCONJ
dti-2469	23	18	sequenced	sequence	VERB
dti-2469	23	19	from	from	ADP
dti-2469	23	20	different	different	ADJ
dti-2469	23	21	ecological	ecological	ADJ
dti-2469	23	22	niches	niche	NOUN
dti-2469	23	23	;	;	PUNCT
dti-2469	23	24	these	these	DET
dti-2469	23	25	sequences	sequence	NOUN
dti-2469	23	26	were	be	AUX
dti-2469	23	27	procured	procure	VERB
dti-2469	23	28	for	for	ADP
dti-2469	23	29	genomic	genomic	ADJ
dti-2469	23	30	comparison	comparison	NOUN
dti-2469	23	31	.	.	PUNCT
dti-2469	24	1	the	the	DET
dti-2469	24	2	availability	availability	NOUN
dti-2469	24	3	of	of	ADP
dti-2469	24	4	genome	genome	NOUN
dti-2469	24	5	sequence	sequence	NOUN
dti-2469	24	6	and	and	CCONJ
dti-2469	24	7	further	further	ADJ
dti-2469	24	8	development	development	NOUN
dti-2469	24	9	in	in	ADP
dti-2469	24	10	genomics	genomic	NOUN
dti-2469	24	11	and	and	CCONJ
dti-2469	24	12	related	relate	VERB
dti-2469	24	13	sciences	science	NOUN
dti-2469	24	14	has	have	AUX
dti-2469	24	15	provided	provide	VERB
dti-2469	24	16	a	a	DET
dti-2469	24	17	platform	platform	NOUN
dti-2469	24	18	to	to	PART
dti-2469	24	19	understand	understand	VERB
dti-2469	24	20	the	the	DET
dti-2469	24	21	functions	function	NOUN
dti-2469	24	22	of	of	ADP
dti-2469	24	23	various	various	ADJ
dti-2469	24	24	proteins	protein	NOUN
dti-2469	24	25	encoded	encode	VERB
dti-2469	24	26	by	by	ADP
dti-2469	24	27	its	its	PRON
dti-2469	24	28	genome	genome	NOUN
dti-2469	24	29	.	.	PUNCT
dti-2469	25	1	the	the	DET
dti-2469	25	2	concept	concept	NOUN
dti-2469	25	3	of	of	ADP
dti-2469	25	4	pangenome	pangenome	NOUN
dti-2469	25	5	can	can	AUX
dti-2469	25	6	be	be	AUX
dti-2469	25	7	applied	apply	VERB
dti-2469	25	8	to	to	PART
dti-2469	25	9	identify	identify	VERB
dti-2469	25	10	different	different	ADJ
dti-2469	25	11	genomes	genome	NOUN
dti-2469	25	12	:	:	PUNCT
dti-2469	25	13	core	core	NOUN
dti-2469	25	14	genome	genome	NOUN
dti-2469	25	15	,	,	PUNCT
dti-2469	25	16	that	that	ADV
dti-2469	25	17	is	is	ADV
dti-2469	25	18	,	,	PUNCT
dti-2469	25	19	genes	gene	NOUN
dti-2469	25	20	present	present	ADJ
dti-2469	25	21	in	in	ADP
dti-2469	25	22	all	all	DET
dti-2469	25	23	strains	strain	NOUN
dti-2469	25	24	of	of	ADP
dti-2469	25	25	the	the	DET
dti-2469	25	26	dataset	dataset	NOUN
dti-2469	25	27	;	;	PUNCT
dti-2469	25	28	dispensable	dispensable	ADJ
dti-2469	25	29	or	or	CCONJ
dti-2469	25	30	accessory	accessory	ADJ
dti-2469	25	31	genome	genome	NOUN
dti-2469	25	32	,	,	PUNCT
dti-2469	25	33	which	which	PRON
dti-2469	25	34	are	be	AUX
dti-2469	25	35	genes	gene	NOUN
dti-2469	25	36	present	present	ADJ
dti-2469	25	37	in	in	ADP
dti-2469	25	38	few	few	ADJ
dti-2469	25	39	strains	strain	NOUN
dti-2469	25	40	of	of	ADP
dti-2469	25	41	the	the	DET
dti-2469	25	42	dataset	dataset	NOUN
dti-2469	25	43	;	;	PUNCT
dti-2469	25	44	and	and	CCONJ
dti-2469	25	45	strain	strain	VERB
dti-2469	25	46	specific	specific	ADJ
dti-2469	25	47	or	or	CCONJ
dti-2469	25	48	unique	unique	ADJ
dti-2469	25	49	genome	genome	NOUN
dti-2469	25	50	,	,	PUNCT
dti-2469	25	51	which	which	PRON
dti-2469	25	52	are	be	AUX
dti-2469	25	53	genes	gene	NOUN
dti-2469	25	54	present	present	ADJ
dti-2469	25	55	in	in	ADP
dti-2469	25	56	only	only	ADV
dti-2469	25	57	one	one	NUM
dti-2469	25	58	strain	strain	NOUN
dti-2469	25	59	and	and	CCONJ
dti-2469	25	60	absent	absent	ADJ
dti-2469	25	61	in	in	ADP
dti-2469	25	62	others	other	NOUN
dti-2469	25	63	(	(	PUNCT
dti-2469	25	64	12	12	NUM
dti-2469	25	65	)	)	PUNCT
dti-2469	25	66	.	.	PUNCT
dti-2469	26	1	core	core	PROPN
dti-2469	26	2	gene(s	gene(s	PROPN
dti-2469	26	3	)	)	PUNCT
dti-2469	26	4	can	can	AUX
dti-2469	26	5	be	be	AUX
dti-2469	26	6	utilized	utilize	VERB
dti-2469	26	7	to	to	PART
dti-2469	26	8	identify	identify	VERB
dti-2469	26	9	the	the	DET
dti-2469	26	10	drug	drug	NOUN
dti-2469	26	11	targets	target	NOUN
dti-2469	26	12	and	and	CCONJ
dti-2469	26	13	design	design	VERB
dti-2469	26	14	broad	broad	ADJ
dti-2469	26	15	-	-	PUNCT
dti-2469	26	16	spectrum	spectrum	NOUN
dti-2469	26	17	antibiotics	antibiotic	NOUN
dti-2469	26	18	for	for	ADP
dti-2469	26	19	pathogenic	pathogenic	ADJ
dti-2469	26	20	species	specie	NOUN
dti-2469	26	21	,	,	PUNCT
dti-2469	26	22	whereas	whereas	SCONJ
dti-2469	26	23	accessory	accessory	NOUN
dti-2469	26	24	and	and	CCONJ
dti-2469	26	25	unique	unique	ADJ
dti-2469	26	26	genes	gene	NOUN
dti-2469	26	27	are	be	AUX
dti-2469	26	28	supposed	suppose	VERB
dti-2469	26	29	to	to	PART
dti-2469	26	30	give	give	VERB
dti-2469	26	31	them	they	PRON
dti-2469	26	32	advantage	advantage	NOUN
dti-2469	26	33	in	in	ADP
dti-2469	26	34	survival	survival	NOUN
dti-2469	26	35	,	,	PUNCT
dti-2469	26	36	pathogenicity	pathogenicity	NOUN
dti-2469	26	37	or	or	CCONJ
dti-2469	26	38	habitat	habitat	NOUN
dti-2469	26	39	adaptation	adaptation	NOUN
dti-2469	26	40	(	(	PUNCT
dti-2469	26	41	13	13	NUM
dti-2469	26	42	)	)	PUNCT
dti-2469	26	43	.	.	PUNCT
dti-2469	27	1	the	the	DET
dti-2469	27	2	analysis	analysis	NOUN
dti-2469	27	3	of	of	ADP
dti-2469	27	4	gene	gene	NOUN
dti-2469	27	5	functions	function	NOUN
dti-2469	27	6	reveals	reveal	VERB
dti-2469	27	7	their	their	PRON
dti-2469	27	8	incorporation	incorporation	NOUN
dti-2469	27	9	in	in	ADP
dti-2469	27	10	different	different	ADJ
dti-2469	27	11	genes	gene	NOUN
dti-2469	27	12	and	and	CCONJ
dti-2469	27	13	their	their	PRON
dti-2469	27	14	proteins	protein	NOUN
dti-2469	27	15	,	,	PUNCT
dti-2469	27	16	which	which	PRON
dti-2469	27	17	are	be	AUX
dti-2469	27	18	functional	functional	ADJ
dti-2469	27	19	in	in	ADP
dti-2469	27	20	various	various	ADJ
dti-2469	27	21	metabolic	metabolic	NOUN
dti-2469	27	22	processes	process	NOUN
dti-2469	27	23	that	that	PRON
dti-2469	27	24	help	help	VERB
dti-2469	27	25	pathogens	pathogen	NOUN
dti-2469	27	26	to	to	PART
dti-2469	27	27	survive	survive	VERB
dti-2469	27	28	in	in	ADP
dti-2469	27	29	the	the	DET
dti-2469	27	30	different	different	ADJ
dti-2469	27	31	ecological	ecological	ADJ
dti-2469	27	32	niches	niche	NOUN
dti-2469	27	33	(	(	PUNCT
dti-2469	27	34	14	14	NUM
dti-2469	27	35	)	)	PUNCT
dti-2469	27	36	.	.	PUNCT
dti-2469	28	1	there	there	PRON
dti-2469	28	2	are	be	VERB
dti-2469	28	3	various	various	ADJ
dti-2469	28	4	bioinformatics	bioinformatics	NOUN
dti-2469	28	5	approaches	approach	NOUN
dti-2469	28	6	to	to	PART
dti-2469	28	7	investigate	investigate	VERB
dti-2469	28	8	the	the	DET
dti-2469	28	9	drug	drug	NOUN
dti-2469	28	10	target	target	NOUN
dti-2469	28	11	from	from	ADP
dti-2469	28	12	the	the	DET
dti-2469	28	13	genome	genome	NOUN
dti-2469	28	14	such	such	ADJ
dti-2469	28	15	as	as	ADP
dti-2469	28	16	ligand	ligand	NOUN
dti-2469	28	17	-	-	PUNCT
dti-2469	28	18	based	base	VERB
dti-2469	28	19	interaction	interaction	NOUN
dti-2469	28	20	fingerprint	fingerprint	NOUN
dti-2469	28	21	,	,	PUNCT
dti-2469	28	22	proteochemometrics	proteochemometric	NOUN
dti-2469	28	23	modelling	modelling	NOUN
dti-2469	28	24	,	,	PUNCT
dti-2469	28	25	linear	linear	ADJ
dti-2469	28	26	interaction	interaction	NOUN
dti-2469	28	27	energy	energy	NOUN
dti-2469	28	28	modelling	modelling	NOUN
dti-2469	28	29	and	and	CCONJ
dti-2469	28	30	many	many	ADJ
dti-2469	28	31	more	more	ADJ
dti-2469	28	32	(	(	PUNCT
dti-2469	28	33	15	15	NUM
dti-2469	28	34	)	)	PUNCT
dti-2469	28	35	.	.	PUNCT
dti-2469	29	1	here	here	ADV
dti-2469	29	2	we	we	PRON
dti-2469	29	3	have	have	AUX
dti-2469	29	4	used	use	VERB
dti-2469	29	5	the	the	DET
dti-2469	29	6	core	core	ADJ
dti-2469	29	7	genome	genome	NOUN
dti-2469	29	8	of	of	ADP
dti-2469	29	9	c.	c.	NOUN
dti-2469	29	10	difficile	difficile	VERB
dti-2469	29	11	to	to	PART
dti-2469	29	12	identify	identify	VERB
dti-2469	29	13	the	the	DET
dti-2469	29	14	drug	drug	NOUN
dti-2469	29	15	target	target	NOUN
dti-2469	29	16	by	by	ADP
dti-2469	29	17	an	an	DET
dti-2469	29	18	integrative	integrative	ADJ
dti-2469	29	19	approach	approach	NOUN
dti-2469	29	20	using	use	VERB
dti-2469	29	21	sequence	sequence	NOUN
dti-2469	29	22	and	and	CCONJ
dti-2469	29	23	interactome	interactome	NOUN
dti-2469	29	24	analysis	analysis	NOUN
dti-2469	29	25	.	.	PUNCT
dti-2469	30	1	conventional	conventional	ADJ
dti-2469	30	2	methods	method	NOUN
dti-2469	30	3	for	for	ADP
dti-2469	30	4	drug	drug	NOUN
dti-2469	30	5	discovery	discovery	NOUN
dti-2469	30	6	are	be	AUX
dti-2469	30	7	very	very	ADV
dti-2469	30	8	costly	costly	ADJ
dti-2469	30	9	and	and	CCONJ
dti-2469	30	10	time	time	NOUN
dti-2469	30	11	consuming	consume	VERB
dti-2469	30	12	;	;	PUNCT
dti-2469	30	13	however	however	ADV
dti-2469	30	14	,	,	PUNCT
dti-2469	30	15	using	use	VERB
dti-2469	30	16	computer	computer	NOUN
dti-2469	30	17	analysis	analysis	NOUN
dti-2469	30	18	at	at	ADP
dti-2469	30	19	initial	initial	ADJ
dti-2469	30	20	stages	stage	NOUN
dti-2469	30	21	can	can	AUX
dti-2469	30	22	reduce	reduce	VERB
dti-2469	30	23	the	the	DET
dti-2469	30	24	cost	cost	NOUN
dti-2469	30	25	and	and	CCONJ
dti-2469	30	26	time	time	NOUN
dti-2469	30	27	.	.	PUNCT
dti-2469	31	1	in	in	ADP
dti-2469	31	2	the	the	DET
dti-2469	31	3	present	present	ADJ
dti-2469	31	4	study	study	NOUN
dti-2469	31	5	,	,	PUNCT
dti-2469	31	6	pangenome	pangenome	NOUN
dti-2469	31	7	analysis	analysis	NOUN
dti-2469	31	8	was	be	AUX
dti-2469	31	9	done	do	VERB
dti-2469	31	10	and	and	CCONJ
dti-2469	31	11	its	its	PRON
dti-2469	31	12	core	core	NOUN
dti-2469	31	13	genome	genome	NOUN
dti-2469	31	14	has	have	AUX
dti-2469	31	15	been	be	AUX
dti-2469	31	16	used	use	VERB
dti-2469	31	17	to	to	PART
dti-2469	31	18	identify	identify	VERB
dti-2469	31	19	the	the	DET
dti-2469	31	20	drug	drug	NOUN
dti-2469	31	21	targets	target	NOUN
dti-2469	31	22	.	.	PUNCT
dti-2469	32	1	this	this	DET
dti-2469	32	2	method	method	NOUN
dti-2469	32	3	has	have	AUX
dti-2469	32	4	been	be	AUX
dti-2469	32	5	developed	develop	VERB
dti-2469	32	6	for	for	ADP
dti-2469	32	7	the	the	DET
dti-2469	32	8	first	first	ADJ
dti-2469	32	9	time	time	NOUN
dti-2469	32	10	to	to	PART
dti-2469	32	11	identify	identify	VERB
dti-2469	32	12	the	the	DET
dti-2469	32	13	drug	drug	NOUN
dti-2469	32	14	targets	target	NOUN
dti-2469	32	15	from	from	ADP
dti-2469	32	16	the	the	DET
dti-2469	32	17	core	core	NOUN
dti-2469	32	18	genome	genome	NOUN
dti-2469	32	19	of	of	ADP
dti-2469	32	20	c.	c.	PROPN
dti-2469	32	21	difficile	difficile	PROPN
dti-2469	32	22	,	,	PUNCT
dti-2469	32	23	which	which	PRON
dti-2469	32	24	can	can	AUX
dti-2469	32	25	be	be	AUX
dti-2469	32	26	used	use	VERB
dti-2469	32	27	in	in	ADP
dti-2469	32	28	the	the	DET
dti-2469	32	29	future	future	NOUN
dti-2469	32	30	for	for	ADP
dti-2469	32	31	other	other	ADJ
dti-2469	32	32	pathogens	pathogen	NOUN
dti-2469	32	33	too	too	ADV
dti-2469	32	34	.	.	PUNCT
dti-2469	33	1	methodology	methodology	NOUN
dti-2469	33	2	collection	collection	NOUN
dti-2469	33	3	of	of	ADP
dti-2469	33	4	genomic	genomic	ADJ
dti-2469	33	5	data	datum	NOUN
dti-2469	33	6	the	the	DET
dti-2469	33	7	strains	strain	NOUN
dti-2469	33	8	of	of	ADP
dti-2469	33	9	c.	c.	NOUN
dti-2469	33	10	difficile	difficile	PROPN
dti-2469	33	11	isolated	isolate	VERB
dti-2469	33	12	from	from	ADP
dti-2469	33	13	almost	almost	ADV
dti-2469	33	14	all	all	DET
dti-2469	33	15	the	the	DET
dti-2469	33	16	geographical	geographical	ADJ
dti-2469	33	17	regions	region	NOUN
dti-2469	33	18	of	of	ADP
dti-2469	33	19	the	the	DET
dti-2469	33	20	world	world	NOUN
dti-2469	33	21	were	be	AUX
dti-2469	33	22	chosen	choose	VERB
dti-2469	33	23	for	for	ADP
dti-2469	33	24	the	the	DET
dti-2469	33	25	present	present	ADJ
dti-2469	33	26	study	study	NOUN
dti-2469	33	27	.	.	PUNCT
dti-2469	34	1	the	the	DET
dti-2469	34	2	complete	complete	ADJ
dti-2469	34	3	genome	genome	NOUN
dti-2469	34	4	sequences	sequence	NOUN
dti-2469	34	5	of	of	ADP
dti-2469	34	6	these	these	DET
dti-2469	34	7	97	97	NUM
dti-2469	34	8	c.	c.	NOUN
dti-2469	34	9	difficile	difficile	VERB
dti-2469	34	10	strains	strain	NOUN
dti-2469	34	11	and	and	CCONJ
dti-2469	34	12	their	their	PRON
dti-2469	34	13	associated	associated	ADJ
dti-2469	34	14	proteomes	proteome	NOUN
dti-2469	34	15	were	be	AUX
dti-2469	34	16	retrieved	retrieve	VERB
dti-2469	34	17	from	from	ADP
dti-2469	34	18	the	the	DET
dti-2469	34	19	genbank	genbank	NOUN
dti-2469	34	20	database	database	NOUN
dti-2469	34	21	(	(	PUNCT
dti-2469	34	22	https://www.ncbi.nlm.nih.gov/	https://www.ncbi.nlm.nih.gov/	NOUN
dti-2469	34	23	genbank/	genbank/	NUM
dti-2469	34	24	)	)	PUNCT
dti-2469	34	25	available	available	ADJ
dti-2469	34	26	at	at	ADP
dti-2469	34	27	the	the	DET
dti-2469	34	28	national	national	ADJ
dti-2469	34	29	center	center	NOUN
dti-2469	34	30	for	for	ADP
dti-2469	34	31	biotechnology	biotechnology	NOUN
dti-2469	34	32	information	information	NOUN
dti-2469	34	33	(	(	PUNCT
dti-2469	34	34	ncbi	ncbi	NOUN
dti-2469	34	35	)	)	PUNCT
dti-2469	34	36	(	(	PUNCT
dti-2469	34	37	16	16	NUM
dti-2469	34	38	)	)	PUNCT
dti-2469	34	39	.	.	PUNCT
dti-2469	35	1	the	the	DET
dti-2469	35	2	assembly	assembly	NOUN
dti-2469	35	3	levels	level	NOUN
dti-2469	35	4	of	of	ADP
dti-2469	35	5	all	all	DET
dti-2469	35	6	these	these	DET
dti-2469	35	7	genomes	genome	NOUN
dti-2469	35	8	were	be	AUX
dti-2469	35	9	complete	complete	ADJ
dti-2469	35	10	,	,	PUNCT
dti-2469	35	11	that	that	ADV
dti-2469	35	12	is	is	ADV
dti-2469	35	13	,	,	PUNCT
dti-2469	35	14	all	all	DET
dti-2469	35	15	the	the	DET
dti-2469	35	16	expected	expect	VERB
dti-2469	35	17	necessary	necessary	ADJ
dti-2469	35	18	chromosomes	chromosome	NOUN
dti-2469	35	19	are	be	AUX
dti-2469	35	20	present	present	ADJ
dti-2469	35	21	with	with	ADP
dti-2469	35	22	no	no	DET
dti-2469	35	23	gaps	gap	NOUN
dti-2469	35	24	.	.	PUNCT
dti-2469	36	1	pangenome	pangenome	NOUN
dti-2469	36	2	analysis	analysis	NOUN
dti-2469	36	3	pangenome	pangenome	NOUN
dti-2469	36	4	analysis	analysis	NOUN
dti-2469	36	5	was	be	AUX
dti-2469	36	6	conducted	conduct	VERB
dti-2469	36	7	on	on	ADP
dti-2469	36	8	these	these	DET
dti-2469	36	9	97	97	NUM
dti-2469	36	10	strains	strain	NOUN
dti-2469	36	11	of	of	ADP
dti-2469	36	12	c.	c.	NOUN
dti-2469	36	13	difficile	difficile	NOUN
dti-2469	36	14	using	use	VERB
dti-2469	36	15	the	the	DET
dti-2469	36	16	bacterial	bacterial	ADJ
dti-2469	36	17	pan	pan	NOUN
dti-2469	36	18	genome	genome	NOUN
dti-2469	36	19	analysis	analysis	NOUN
dti-2469	36	20	(	(	PUNCT
dti-2469	36	21	bpga	bpga	NOUN
dti-2469	36	22	)	)	PUNCT
dti-2469	36	23	tool	tool	NOUN
dti-2469	36	24	(	(	PUNCT
dti-2469	36	25	17	17	NUM
dti-2469	36	26	)	)	PUNCT
dti-2469	36	27	.	.	PUNCT
dti-2469	37	1	for	for	ADP
dti-2469	37	2	this	this	PRON
dti-2469	37	3	,	,	PUNCT
dti-2469	37	4	we	we	PRON
dti-2469	37	5	have	have	AUX
dti-2469	37	6	used	use	VERB
dti-2469	37	7	usearch	usearch	NOUN
dti-2469	37	8	algorithm	algorithm	NOUN
dti-2469	37	9	to	to	PART
dti-2469	37	10	generate	generate	VERB
dti-2469	37	11	orthologous	orthologous	ADJ
dti-2469	37	12	protein	protein	NOUN
dti-2469	37	13	clusters	cluster	NOUN
dti-2469	37	14	with	with	ADP
dti-2469	37	15	the	the	DET
dti-2469	37	16	default	default	NOUN
dti-2469	37	17	threshold	threshold	NOUN
dti-2469	37	18	of	of	ADP
dti-2469	37	19	50	50	NUM
dti-2469	37	20	%	%	NOUN
dti-2469	37	21	identity	identity	NOUN
dti-2469	37	22	(	(	PUNCT
dti-2469	37	23	18	18	NUM
dti-2469	37	24	)	)	PUNCT
dti-2469	37	25	.	.	PUNCT
dti-2469	38	1	by	by	ADP
dti-2469	38	2	examining	examine	VERB
dti-2469	38	3	20	20	NUM
dti-2469	38	4	permutations	permutation	NOUN
dti-2469	38	5	at	at	ADP
dti-2469	38	6	random	random	ADJ
dti-2469	38	7	and	and	CCONJ
dti-2469	38	8	giving	give	VERB
dti-2469	38	9	median	median	ADJ
dti-2469	38	10	values	value	NOUN
dti-2469	38	11	after	after	SCONJ
dti-2469	38	12	each	each	DET
dti-2469	38	13	genome	genome	NOUN
dti-2469	38	14	is	be	AUX
dti-2469	38	15	added	add	VERB
dti-2469	38	16	,	,	PUNCT
dti-2469	38	17	the	the	DET
dti-2469	38	18	pan	pan	NOUN
dti-2469	38	19	and	and	CCONJ
dti-2469	38	20	core	core	NOUN
dti-2469	38	21	genome	genome	NOUN
dti-2469	38	22	size	size	NOUN
dti-2469	38	23	is	be	AUX
dti-2469	38	24	determined	determine	VERB
dti-2469	38	25	.	.	PUNCT
dti-2469	39	1	by	by	ADP
dti-2469	39	2	comparing	compare	VERB
dti-2469	39	3	the	the	DET
dti-2469	39	4	common	common	ADJ
dti-2469	39	5	gene	gene	NOUN
dti-2469	39	6	and	and	CCONJ
dti-2469	39	7	unique	unique	ADJ
dti-2469	39	8	gene	gene	NOUN
dti-2469	39	9	families	family	NOUN
dti-2469	39	10	to	to	ADP
dti-2469	39	11	the	the	DET
dti-2469	39	12	entire	entire	ADJ
dti-2469	39	13	genome	genome	NOUN
dti-2469	39	14	,	,	PUNCT
dti-2469	39	15	core	core	NOUN
dti-2469	39	16	and	and	CCONJ
dti-2469	39	17	pan	pan	NOUN
dti-2469	39	18	genome	genome	NOUN
dti-2469	39	19	curves	curve	NOUN
dti-2469	39	20	,	,	PUNCT
dti-2469	39	21	respectively	respectively	ADV
dti-2469	39	22	,	,	PUNCT
dti-2469	39	23	are	be	AUX
dti-2469	39	24	created	create	VERB
dti-2469	39	25	.	.	PUNCT
dti-2469	40	1	in	in	ADP
dti-2469	40	2	addition	addition	NOUN
dti-2469	40	3	,	,	PUNCT
dti-2469	40	4	it	it	PRON
dti-2469	40	5	also	also	ADV
dti-2469	40	6	generates	generate	VERB
dti-2469	40	7	the	the	DET
dti-2469	40	8	pan	pan	NOUN
dti-2469	40	9	phylogeny	phylogeny	NOUN
dti-2469	40	10	using	use	VERB
dti-2469	40	11	the	the	DET
dti-2469	40	12	pan	pan	NOUN
dti-2469	40	13	matrix	matrix	NOUN
dti-2469	40	14	data	datum	NOUN
dti-2469	40	15	.	.	PUNCT
dti-2469	41	1	using	use	VERB
dti-2469	41	2	neighbour	neighbour	NOUN
dti-2469	41	3	-	-	PUNCT
dti-2469	41	4	joining	join	VERB
dti-2469	41	5	method	method	NOUN
dti-2469	41	6	,	,	PUNCT
dti-2469	41	7	a	a	DET
dti-2469	41	8	pangenome	pangenome	NOUN
dti-2469	41	9	tree	tree	NOUN
dti-2469	41	10	was	be	AUX
dti-2469	41	11	constructed	construct	VERB
dti-2469	41	12	with	with	ADP
dti-2469	41	13	a	a	DET
dti-2469	41	14	default	default	NOUN
dti-2469	41	15	combination	combination	NOUN
dti-2469	41	16	value	value	NOUN
dti-2469	41	17	of	of	ADP
dti-2469	41	18	20	20	NUM
dti-2469	41	19	iterations	iteration	NOUN
dti-2469	41	20	.	.	PUNCT
dti-2469	42	1	functional	functional	ADJ
dti-2469	42	2	analysis	analysis	NOUN
dti-2469	42	3	all	all	DET
dti-2469	42	4	the	the	DET
dti-2469	42	5	accessory	accessory	NOUN
dti-2469	42	6	and	and	CCONJ
dti-2469	42	7	unique	unique	ADJ
dti-2469	42	8	genes	gene	NOUN
dti-2469	42	9	were	be	AUX
dti-2469	42	10	subjected	subject	VERB
dti-2469	42	11	to	to	ADP
dti-2469	42	12	functional	functional	ADJ
dti-2469	42	13	analysis	analysis	NOUN
dti-2469	42	14	using	use	VERB
dti-2469	42	15	protein	protein	NOUN
dti-2469	42	16	blast	blast	NOUN
dti-2469	42	17	against	against	ADP
dti-2469	42	18	cog	cog	PROPN
dti-2469	42	19	(	(	PUNCT
dti-2469	42	20	clusters	cluster	NOUN
dti-2469	42	21	of	of	ADP
dti-2469	42	22	orthologous	orthologous	ADJ
dti-2469	42	23	genes	gene	NOUN
dti-2469	42	24	)	)	PUNCT
dti-2469	42	25	and	and	CCONJ
dti-2469	42	26	kegg	kegg	NOUN
dti-2469	42	27	(	(	PUNCT
dti-2469	42	28	kyoto	kyoto	PROPN
dti-2469	42	29	encyclopedia	encyclopedia	NOUN
dti-2469	42	30	of	of	ADP
dti-2469	42	31	genes	gene	NOUN
dti-2469	42	32	and	and	CCONJ
dti-2469	42	33	genomes	genome	NOUN
dti-2469	42	34	)	)	PUNCT
dti-2469	42	35	databases	database	NOUN
dti-2469	42	36	(	(	PUNCT
dti-2469	42	37	19,20	19,20	NOUN
dti-2469	42	38	)	)	PUNCT
dti-2469	42	39	.	.	PUNCT
dti-2469	43	1	the	the	DET
dti-2469	43	2	percentage	percentage	NOUN
dti-2469	43	3	frequencies	frequency	NOUN
dti-2469	43	4	of	of	ADP
dti-2469	43	5	these	these	DET
dti-2469	43	6	cog	cog	PROPN
dti-2469	43	7	and	and	CCONJ
dti-2469	43	8	kegg	kegg	NOUN
dti-2469	43	9	categories	category	NOUN
dti-2469	43	10	are	be	AUX
dti-2469	43	11	calculated	calculate	VERB
dti-2469	43	12	for	for	ADP
dti-2469	43	13	each	each	DET
dti-2469	43	14	gene	gene	NOUN
dti-2469	43	15	and	and	CCONJ
dti-2469	43	16	their	their	PRON
dti-2469	43	17	outputs	output	NOUN
dti-2469	43	18	are	be	AUX
dti-2469	43	19	generated	generate	VERB
dti-2469	43	20	in	in	ADP
dti-2469	43	21	the	the	DET
dti-2469	43	22	form	form	NOUN
dti-2469	43	23	of	of	ADP
dti-2469	43	24	charts	chart	NOUN
dti-2469	43	25	.	.	PUNCT
dti-2469	44	1	identification	identification	NOUN
dti-2469	44	2	of	of	ADP
dti-2469	44	3	drug	drug	NOUN
dti-2469	44	4	targets	target	NOUN
dti-2469	44	5	core	core	NOUN
dti-2469	44	6	genome	genome	NOUN
dti-2469	44	7	obtained	obtain	VERB
dti-2469	44	8	from	from	ADP
dti-2469	44	9	pangenome	pangenome	NOUN
dti-2469	44	10	analysis	analysis	NOUN
dti-2469	44	11	was	be	AUX
dti-2469	44	12	used	use	VERB
dti-2469	44	13	to	to	PART
dti-2469	44	14	identify	identify	VERB
dti-2469	44	15	the	the	DET
dti-2469	44	16	potent	potent	ADJ
dti-2469	44	17	drug	drug	NOUN
dti-2469	44	18	targets	target	NOUN
dti-2469	44	19	.	.	PUNCT
dti-2469	45	1	initially	initially	ADV
dti-2469	45	2	,	,	PUNCT
dti-2469	45	3	all	all	DET
dti-2469	45	4	the	the	DET
dti-2469	45	5	core	core	NOUN
dti-2469	45	6	genes	gene	NOUN
dti-2469	45	7	were	be	AUX
dti-2469	45	8	subjected	subject	VERB
dti-2469	45	9	to	to	PART
dti-2469	45	10	blast	blast	VERB
dti-2469	45	11	search	search	NOUN
dti-2469	45	12	against	against	ADP
dti-2469	45	13	human	human	NOUN
dti-2469	45	14	(	(	PUNCT
dti-2469	45	15	21	21	NUM
dti-2469	45	16	)	)	PUNCT
dti-2469	45	17	.	.	PUNCT
dti-2469	46	1	genes	gene	NOUN
dti-2469	46	2	with	with	ADP
dti-2469	46	3	the	the	DET
dti-2469	46	4	e	e	NOUN
dti-2469	46	5	-	-	NOUN
dti-2469	46	6	value	value	NOUN
dti-2469	46	7	greater	great	ADJ
dti-2469	46	8	than	than	ADP
dti-2469	46	9	1	1	NUM
dti-2469	46	10	×	×	NOUN
dti-2469	46	11	10–3	10–3	PROPN
dti-2469	46	12	were	be	AUX
dti-2469	46	13	considered	consider	VERB
dti-2469	46	14	as	as	ADP
dti-2469	46	15	non	non	ADJ
dti-2469	46	16	-	-	ADJ
dti-2469	46	17	homologous	homologous	ADJ
dti-2469	46	18	.	.	PUNCT
dti-2469	47	1	this	this	PRON
dti-2469	47	2	is	be	AUX
dti-2469	47	3	done	do	VERB
dti-2469	47	4	to	to	PART
dti-2469	47	5	reduce	reduce	VERB
dti-2469	47	6	the	the	DET
dti-2469	47	7	cross	cross	NOUN
dti-2469	47	8	reactivity	reactivity	NOUN
dti-2469	47	9	with	with	ADP
dti-2469	47	10	the	the	DET
dti-2469	47	11	human	human	ADJ
dti-2469	47	12	genome	genome	NOUN
dti-2469	47	13	and	and	CCONJ
dti-2469	47	14	to	to	PART
dti-2469	47	15	decrease	decrease	VERB
dti-2469	47	16	drug	drug	NOUN
dti-2469	47	17	toxicity	toxicity	NOUN
dti-2469	47	18	.	.	PUNCT
dti-2469	48	1	the	the	DET
dti-2469	48	2	resultant	resultant	NOUN
dti-2469	48	3	non	non	ADJ
dti-2469	48	4	-	-	ADJ
dti-2469	48	5	homologous	homologous	ADJ
dti-2469	48	6	genes	gene	NOUN
dti-2469	48	7	(	(	PUNCT
dti-2469	48	8	to	to	ADP
dti-2469	48	9	human	human	NOUN
dti-2469	48	10	)	)	PUNCT
dti-2469	48	11	were	be	AUX
dti-2469	48	12	subjected	subject	VERB
dti-2469	48	13	to	to	PART
dti-2469	48	14	blast	blast	VERB
dti-2469	48	15	against	against	ADP
dti-2469	48	16	deg	deg	PROPN
dti-2469	48	17	(	(	PUNCT
dti-2469	48	18	database	database	NOUN
dti-2469	48	19	of	of	ADP
dti-2469	48	20	essential	essential	ADJ
dti-2469	48	21	genes	gene	NOUN
dti-2469	48	22	)	)	PUNCT
dti-2469	48	23	to	to	PART
dti-2469	48	24	identify	identify	VERB
dti-2469	48	25	the	the	DET
dti-2469	48	26	genes	gene	NOUN
dti-2469	48	27	that	that	PRON
dti-2469	48	28	were	be	AUX
dti-2469	48	29	essential	essential	ADJ
dti-2469	48	30	for	for	ADP
dti-2469	48	31	bacterial	bacterial	ADJ
dti-2469	48	32	sustainability	sustainability	NOUN
dti-2469	48	33	.	.	PUNCT
dti-2469	49	1	deg	deg	PROPN
dti-2469	49	2	contains	contain	VERB
dti-2469	49	3	experimentally	experimentally	ADV
dti-2469	49	4	validated	validate	VERB
dti-2469	49	5	genes	gene	NOUN
dti-2469	49	6	of	of	ADP
dti-2469	49	7	many	many	ADJ
dti-2469	49	8	genera	genera	NOUN
dti-2469	49	9	that	that	PRON
dti-2469	49	10	are	be	AUX
dti-2469	49	11	essential	essential	ADJ
dti-2469	49	12	for	for	ADP
dti-2469	49	13	survival	survival	NOUN
dti-2469	49	14	(	(	PUNCT
dti-2469	49	15	22	22	NUM
dti-2469	49	16	)	)	PUNCT
dti-2469	49	17	.	.	PUNCT
dti-2469	50	1	to	to	PART
dti-2469	50	2	shortlist	shortlist	VERB
dti-2469	50	3	essential	essential	ADJ
dti-2469	50	4	genes	gene	NOUN
dti-2469	50	5	,	,	PUNCT
dti-2469	50	6	e	e	NOUN
dti-2469	50	7	-	-	NOUN
dti-2469	50	8	value	value	NOUN
dti-2469	50	9	<	<	NOUN
dti-2469	50	10	0.0001	0.0001	NUM
dti-2469	50	11	and	and	CCONJ
dti-2469	50	12	bit	bit	NOUN
dti-2469	50	13	score	score	NOUN
dti-2469	50	14	>	>	X
dti-2469	50	15	100	100	NUM
dti-2469	50	16	was	be	AUX
dti-2469	50	17	used	use	VERB
dti-2469	50	18	.	.	PUNCT
dti-2469	51	1	the	the	DET
dti-2469	51	2	essential	essential	ADJ
dti-2469	51	3	genes	gene	NOUN
dti-2469	51	4	involved	involve	VERB
dti-2469	51	5	in	in	ADP
dti-2469	51	6	vital	vital	ADJ
dti-2469	51	7	function	function	NOUN
dti-2469	51	8	are	be	AUX
dti-2469	51	9	targeted	target	VERB
dti-2469	51	10	,	,	PUNCT
dti-2469	51	11	such	such	ADJ
dti-2469	51	12	that	that	SCONJ
dti-2469	51	13	the	the	DET
dti-2469	51	14	pathogen	pathogen	NOUN
dti-2469	51	15	is	be	AUX
dti-2469	51	16	affected	affect	VERB
dti-2469	51	17	and	and	CCONJ
dti-2469	51	18	killed	kill	VERB
dti-2469	51	19	.	.	PUNCT
dti-2469	52	1	all	all	DET
dti-2469	52	2	nonhomologous	nonhomologous	ADJ
dti-2469	52	3	and	and	CCONJ
dti-2469	52	4	essential	essential	ADJ
dti-2469	52	5	genes	gene	NOUN
dti-2469	52	6	were	be	AUX
dti-2469	52	7	subjected	subject	VERB
dti-2469	52	8	to	to	ADP
dti-2469	52	9	virulence	virulence	NOUN
dti-2469	52	10	study	study	NOUN
dti-2469	52	11	.	.	PUNCT
dti-2469	53	1	vfdb	vfdb	PROPN
dti-2469	53	2	(	(	PUNCT
dti-2469	53	3	virulence	virulence	NOUN
dti-2469	53	4	factor	factor	NOUN
dti-2469	53	5	database	database	NOUN
dti-2469	53	6	)	)	PUNCT
dti-2469	53	7	is	be	AUX
dti-2469	53	8	a	a	DET
dti-2469	53	9	comprehensive	comprehensive	ADJ
dti-2469	53	10	database	database	NOUN
dti-2469	53	11	that	that	PRON
dti-2469	53	12	provides	provide	VERB
dti-2469	53	13	information	information	NOUN
dti-2469	53	14	about	about	ADP
dti-2469	53	15	virulence	virulence	NOUN
dti-2469	53	16	factors	factor	NOUN
dti-2469	53	17	,	,	PUNCT
dti-2469	53	18	which	which	PRON
dti-2469	53	19	are	be	AUX
dti-2469	53	20	the	the	DET
dti-2469	53	21	gene	gene	NOUN
dti-2469	53	22	products	product	NOUN
dti-2469	53	23	that	that	PRON
dti-2469	53	24	help	help	VERB
dti-2469	53	25	the	the	DET
dti-2469	53	26	pathogen	pathogen	NOUN
dti-2469	53	27	to	to	PART
dti-2469	53	28	grow	grow	VERB
dti-2469	53	29	inside	inside	ADP
dti-2469	53	30	host	host	NOUN
dti-2469	53	31	and	and	CCONJ
dti-2469	53	32	increase	increase	VERB
dti-2469	53	33	its	its	PRON
dti-2469	53	34	ability	ability	NOUN
dti-2469	53	35	to	to	PART
dti-2469	53	36	cause	cause	VERB
dti-2469	53	37	disease	disease	NOUN
dti-2469	53	38	(	(	PUNCT
dti-2469	53	39	23	23	NUM
dti-2469	53	40	)	)	PUNCT
dti-2469	53	41	.	.	PUNCT
dti-2469	54	1	all	all	DET
dti-2469	54	2	the	the	DET
dti-2469	54	3	selected	select	VERB
dti-2469	54	4	proteins	protein	NOUN
dti-2469	54	5	were	be	AUX
dti-2469	54	6	filtered	filter	VERB
dti-2469	54	7	on	on	ADP
dti-2469	54	8	the	the	DET
dti-2469	54	9	basis	basis	NOUN
dti-2469	54	10	of	of	ADP
dti-2469	54	11	their	their	PRON
dti-2469	54	12	physicochemical	physicochemical	ADJ
dti-2469	54	13	properties	property	NOUN
dti-2469	54	14	such	such	ADJ
dti-2469	54	15	as	as	ADP
dti-2469	54	16	number	number	NOUN
dti-2469	54	17	of	of	ADP
dti-2469	54	18	amino	amino	ADJ
dti-2469	54	19	acids	acid	NOUN
dti-2469	54	20	,	,	PUNCT
dti-2469	54	21	molecular	molecular	ADJ
dti-2469	54	22	weight	weight	NOUN
dti-2469	54	23	,	,	PUNCT
dti-2469	54	24	isoelectric	isoelectric	ADJ
dti-2469	54	25	point	point	NOUN
dti-2469	54	26	(	(	PUNCT
dti-2469	54	27	pi	pi	NOUN
dti-2469	54	28	)	)	PUNCT
dti-2469	54	29	,	,	PUNCT
dti-2469	54	30	gravy	gravy	NOUN
dti-2469	54	31	(	(	PUNCT
dti-2469	54	32	grand	grand	ADJ
dti-2469	54	33	average	average	NOUN
dti-2469	54	34	of	of	ADP
dti-2469	54	35	hydropathicity	hydropathicity	NOUN
dti-2469	54	36	)	)	PUNCT
dti-2469	54	37	value	value	NOUN
dti-2469	54	38	,	,	PUNCT
dti-2469	54	39	aliphatic	aliphatic	ADJ
dti-2469	54	40	index	index	NOUN
dti-2469	54	41	and	and	CCONJ
dti-2469	54	42	subcellular	subcellular	ADJ
dti-2469	54	43	localization	localization	NOUN
dti-2469	54	44	.	.	PUNCT
dti-2469	55	1	except	except	SCONJ
dti-2469	55	2	subcellular	subcellular	ADJ
dti-2469	55	3	localization	localization	NOUN
dti-2469	55	4	,	,	PUNCT
dti-2469	55	5	all	all	DET
dti-2469	55	6	the	the	DET
dti-2469	55	7	parameters	parameter	NOUN
dti-2469	55	8	are	be	AUX
dti-2469	55	9	calculated	calculate	VERB
dti-2469	55	10	using	use	VERB
dti-2469	55	11	protparam	protparam	PROPN
dti-2469	55	12	tool	tool	NOUN
dti-2469	55	13	and	and	CCONJ
dti-2469	55	14	subcellular	subcellular	ADJ
dti-2469	55	15	localization	localization	NOUN
dti-2469	55	16	is	be	AUX
dti-2469	55	17	predicted	predict	VERB
dti-2469	55	18	using	use	VERB
dti-2469	55	19	cello	cello	NOUN
dti-2469	55	20	(	(	PUNCT
dti-2469	55	21	24,25	24,25	NUM
dti-2469	55	22	)	)	PUNCT
dti-2469	55	23	.	.	PUNCT
dti-2469	56	1	sequences	sequence	NOUN
dti-2469	56	2	with	with	ADP
dti-2469	56	3	less	less	ADJ
dti-2469	56	4	than	than	ADP
dti-2469	56	5	100	100	NUM
dti-2469	56	6	amino	amino	ADJ
dti-2469	56	7	acids	acid	NOUN
dti-2469	56	8	called	call	VERB
dti-2469	56	9	peptides	peptide	NOUN
dti-2469	56	10	are	be	AUX
dti-2469	56	11	excluded	exclude	VERB
dti-2469	56	12	from	from	ADP
dti-2469	56	13	the	the	DET
dti-2469	56	14	present	present	ADJ
dti-2469	56	15	study	study	NOUN
dti-2469	56	16	.	.	PUNCT
dti-2469	57	1	similarly	similarly	ADV
dti-2469	57	2	,	,	PUNCT
dti-2469	57	3	drugs	drug	NOUN
dti-2469	57	4	are	be	AUX
dti-2469	57	5	more	more	ADV
dti-2469	57	6	accessible	accessible	ADJ
dti-2469	57	7	to	to	ADP
dti-2469	57	8	low	low	ADJ
dti-2469	57	9	molecular	molecular	ADJ
dti-2469	57	10	weight	weight	NOUN
dti-2469	57	11	targets	target	NOUN
dti-2469	57	12	,	,	PUNCT
dti-2469	57	13	therefore	therefore	ADV
dti-2469	57	14	sequences	sequence	NOUN
dti-2469	57	15	with	with	ADP
dti-2469	57	16	more	more	ADJ
dti-2469	57	17	than	than	ADP
dti-2469	57	18	75	75	NUM
dti-2469	57	19	kda	kda	NOUN
dti-2469	57	20	are	be	AUX
dti-2469	57	21	also	also	ADV
dti-2469	57	22	excluded	exclude	VERB
dti-2469	57	23	(	(	PUNCT
dti-2469	57	24	26	26	NUM
dti-2469	57	25	)	)	PUNCT
dti-2469	57	26	.	.	PUNCT
dti-2469	58	1	the	the	DET
dti-2469	58	2	drug	drug	NOUN
dti-2469	58	3	targets	target	NOUN
dti-2469	58	4	having	have	VERB
dti-2469	58	5	low	low	ADJ
dti-2469	58	6	pi	pi	NOUN
dti-2469	58	7	have	have	AUX
dti-2469	58	8	been	be	AUX
dti-2469	58	9	included	include	VERB
dti-2469	58	10	in	in	ADP
dti-2469	58	11	this	this	DET
dti-2469	58	12	study	study	NOUN
dti-2469	58	13	,	,	PUNCT
dti-2469	58	14	which	which	PRON
dti-2469	58	15	is	be	AUX
dti-2469	58	16	in	in	ADP
dti-2469	58	17	accordance	accordance	NOUN
dti-2469	58	18	with	with	ADP
dti-2469	58	19	the	the	DET
dti-2469	58	20	study	study	NOUN
dti-2469	58	21	of	of	ADP
dti-2469	58	22	bakheet	bakheet	NOUN
dti-2469	58	23	and	and	CCONJ
dti-2469	58	24	doig	doig	PROPN
dti-2469	58	25	(	(	PUNCT
dti-2469	58	26	27	27	NUM
dti-2469	58	27	)	)	PUNCT
dti-2469	58	28	.	.	PUNCT
dti-2469	59	1	in	in	ADP
dti-2469	59	2	addition	addition	NOUN
dti-2469	59	3	,	,	PUNCT
dti-2469	59	4	negative	negative	ADJ
dti-2469	59	5	gravy	gravy	NOUN
dti-2469	59	6	value	value	NOUN
dti-2469	59	7	indicated	indicate	VERB
dti-2469	59	8	the	the	DET
dti-2469	59	9	hydrophilic	hydrophilic	ADJ
dti-2469	59	10	nature	nature	NOUN
dti-2469	59	11	of	of	ADP
dti-2469	59	12	drug	drug	NOUN
dti-2469	59	13	target	target	NOUN
dti-2469	59	14	and	and	CCONJ
dti-2469	59	15	higher	high	ADJ
dti-2469	59	16	value	value	NOUN
dti-2469	59	17	of	of	ADP
dti-2469	59	18	aliphatic	aliphatic	ADJ
dti-2469	59	19	index	index	NOUN
dti-2469	59	20	indicates	indicate	VERB
dti-2469	59	21	thermostability	thermostability	NOUN
dti-2469	59	22	(	(	PUNCT
dti-2469	59	23	28,29	28,29	NUM
dti-2469	59	24	)	)	PUNCT
dti-2469	59	25	.	.	PUNCT
dti-2469	60	1	all	all	DET
dti-2469	60	2	extracellularly	extracellularly	ADV
dti-2469	60	3	localized	localize	VERB
dti-2469	60	4	proteins	protein	NOUN
dti-2469	60	5	were	be	AUX
dti-2469	60	6	also	also	ADV
dti-2469	60	7	excluded	exclude	VERB
dti-2469	60	8	from	from	ADP
dti-2469	60	9	the	the	DET
dti-2469	60	10	study	study	NOUN
dti-2469	60	11	,	,	PUNCT
dti-2469	60	12	these	these	PRON
dti-2469	60	13	being	be	AUX
dti-2469	60	14	secreted	secrete	VERB
dti-2469	60	15	outside	outside	ADP
dti-2469	60	16	the	the	DET
dti-2469	60	17	cell	cell	NOUN
dti-2469	60	18	(	(	PUNCT
dti-2469	60	19	30	30	NUM
dti-2469	60	20	)	)	PUNCT
dti-2469	60	21	.	.	PUNCT
dti-2469	61	1	interactome	interactome	NOUN
dti-2469	61	2	analysis	analysis	NOUN
dti-2469	61	3	to	to	PART
dti-2469	61	4	search	search	VERB
dti-2469	61	5	the	the	DET
dti-2469	61	6	key	key	ADJ
dti-2469	61	7	proteins	protein	NOUN
dti-2469	61	8	(	(	PUNCT
dti-2469	61	9	from	from	ADP
dti-2469	61	10	selected	select	VERB
dti-2469	61	11	proteins	protein	NOUN
dti-2469	61	12	)	)	PUNCT
dti-2469	61	13	,	,	PUNCT
dti-2469	61	14	the	the	DET
dti-2469	61	15	choke	choke	NOUN
dti-2469	61	16	point	point	VERB
dti-2469	61	17	analysis	analysis	NOUN
dti-2469	61	18	using	use	VERB
dti-2469	61	19	pathway	pathway	NOUN
dti-2469	61	20	tool	tool	NOUN
dti-2469	61	21	is	be	AUX
dti-2469	61	22	performed	perform	VERB
dti-2469	61	23	to	to	PART
dti-2469	61	24	find	find	VERB
dti-2469	61	25	https://www.ncbi.nlm.nih.gov/genbank/	https://www.ncbi.nlm.nih.gov/genbank/	PROPN
dti-2469	61	26	https://www.ncbi.nlm.nih.gov/genbank/	https://www.ncbi.nlm.nih.gov/genbank/	PROPN
dti-2469	61	27	golchha	golchha	PROPN
dti-2469	61	28	et	et	PROPN
dti-2469	61	29	al	al	PROPN
dti-2469	61	30	drug	drug	PROPN
dti-2469	61	31	target	target	NOUN
dti-2469	61	32	insights	insight	NOUN
dti-2469	61	33	2022	2022	NUM
dti-2469	61	34	;	;	PUNCT
dti-2469	61	35	16	16	NUM
dti-2469	61	36	:	:	SYM
dti-2469	61	37	19	19	NUM
dti-2469	61	38	©	©	PROPN
dti-2469	61	39	2022	2022	NUM
dti-2469	61	40	the	the	DET
dti-2469	61	41	authors	author	NOUN
dti-2469	61	42	.	.	PUNCT
dti-2469	62	1	published	publish	VERB
dti-2469	62	2	by	by	ADP
dti-2469	62	3	aboutscience	aboutscience	NOUN
dti-2469	62	4	www.aboutscience.eu	www.aboutscience.eu	NOUN
dti-2469	62	5	out	out	ADP
dti-2469	62	6	the	the	DET
dti-2469	62	7	proteins	protein	NOUN
dti-2469	62	8	which	which	PRON
dti-2469	62	9	were	be	AUX
dti-2469	62	10	specific	specific	ADJ
dti-2469	62	11	in	in	ADP
dti-2469	62	12	the	the	DET
dti-2469	62	13	metabolic	metabolic	NOUN
dti-2469	62	14	network	network	NOUN
dti-2469	62	15	and	and	CCONJ
dti-2469	62	16	whose	whose	DET
dti-2469	62	17	function	function	NOUN
dti-2469	62	18	can	can	AUX
dti-2469	62	19	not	not	PART
dti-2469	62	20	be	be	AUX
dti-2469	62	21	replaced	replace	VERB
dti-2469	62	22	by	by	ADP
dti-2469	62	23	any	any	DET
dti-2469	62	24	other	other	ADJ
dti-2469	62	25	protein	protein	NOUN
dti-2469	62	26	(	(	PUNCT
dti-2469	62	27	31	31	NUM
dti-2469	62	28	)	)	PUNCT
dti-2469	62	29	.	.	PUNCT
dti-2469	63	1	a	a	DET
dti-2469	63	2	choke	choke	NOUN
dti-2469	63	3	point	point	NOUN
dti-2469	63	4	protein	protein	NOUN
dti-2469	63	5	is	be	AUX
dti-2469	63	6	compulsory	compulsory	ADJ
dti-2469	63	7	for	for	ADP
dti-2469	63	8	any	any	DET
dti-2469	63	9	pathway	pathway	NOUN
dti-2469	63	10	and	and	CCONJ
dti-2469	63	11	is	be	AUX
dti-2469	63	12	essential	essential	ADJ
dti-2469	63	13	for	for	ADP
dti-2469	63	14	pathogen	pathogen	NOUN
dti-2469	63	15	survival	survival	NOUN
dti-2469	63	16	.	.	PUNCT
dti-2469	64	1	targeting	target	VERB
dti-2469	64	2	choke	choke	NOUN
dti-2469	64	3	point	point	NOUN
dti-2469	64	4	protein	protein	NOUN
dti-2469	64	5	affects	affect	VERB
dti-2469	64	6	the	the	DET
dti-2469	64	7	metabolic	metabolic	NOUN
dti-2469	64	8	pathway	pathway	NOUN
dti-2469	64	9	,	,	PUNCT
dti-2469	64	10	which	which	PRON
dti-2469	64	11	results	result	VERB
dti-2469	64	12	in	in	ADP
dti-2469	64	13	death	death	NOUN
dti-2469	64	14	of	of	ADP
dti-2469	64	15	the	the	DET
dti-2469	64	16	pathogen	pathogen	NOUN
dti-2469	64	17	.	.	PUNCT
dti-2469	65	1	further	further	ADJ
dti-2469	65	2	analysis	analysis	NOUN
dti-2469	65	3	was	be	AUX
dti-2469	65	4	done	do	VERB
dti-2469	65	5	using	use	VERB
dti-2469	65	6	interactome	interactome	NOUN
dti-2469	65	7	studies	study	NOUN
dti-2469	65	8	,	,	PUNCT
dti-2469	65	9	in	in	ADP
dti-2469	65	10	which	which	PRON
dti-2469	65	11	the	the	DET
dti-2469	65	12	input	input	NOUN
dti-2469	65	13	of	of	ADP
dti-2469	65	14	all	all	DET
dti-2469	65	15	choke	choke	NOUN
dti-2469	65	16	point	point	NOUN
dti-2469	65	17	proteins	protein	NOUN
dti-2469	65	18	was	be	AUX
dti-2469	65	19	given	give	VERB
dti-2469	65	20	to	to	ADP
dti-2469	65	21	the	the	DET
dti-2469	65	22	string	string	NOUN
dti-2469	65	23	database	database	NOUN
dti-2469	65	24	and	and	CCONJ
dti-2469	65	25	network	network	NOUN
dti-2469	65	26	was	be	AUX
dti-2469	65	27	created	create	VERB
dti-2469	65	28	at	at	ADP
dti-2469	65	29	high	high	ADJ
dti-2469	65	30	confidence	confidence	NOUN
dti-2469	65	31	level	level	NOUN
dti-2469	65	32	(	(	PUNCT
dti-2469	65	33	32	32	NUM
dti-2469	65	34	)	)	PUNCT
dti-2469	65	35	.	.	PUNCT
dti-2469	66	1	the	the	DET
dti-2469	66	2	metabolic	metabolic	ADJ
dti-2469	66	3	functional	functional	ADJ
dti-2469	66	4	interaction	interaction	NOUN
dti-2469	66	5	was	be	AUX
dti-2469	66	6	created	create	VERB
dti-2469	66	7	using	use	VERB
dti-2469	66	8	various	various	ADJ
dti-2469	66	9	methods	method	NOUN
dti-2469	66	10	such	such	ADJ
dti-2469	66	11	as	as	ADP
dti-2469	66	12	gene	gene	NOUN
dti-2469	66	13	fusion	fusion	NOUN
dti-2469	66	14	,	,	PUNCT
dti-2469	66	15	neighbourhood	neighbourhood	NOUN
dti-2469	66	16	,	,	PUNCT
dti-2469	66	17	co	co	NOUN
dti-2469	66	18	-	-	NOUN
dti-2469	66	19	occurrence	occurrence	NOUN
dti-2469	66	20	,	,	PUNCT
dti-2469	66	21	co	co	NOUN
dti-2469	66	22	-	-	NOUN
dti-2469	66	23	expression	expression	NOUN
dti-2469	66	24	and	and	CCONJ
dti-2469	66	25	text	text	NOUN
dti-2469	66	26	mining	mining	NOUN
dti-2469	66	27	.	.	PUNCT
dti-2469	67	1	the	the	DET
dti-2469	67	2	interactome	interactome	NOUN
dti-2469	67	3	was	be	AUX
dti-2469	67	4	downloaded	download	VERB
dti-2469	67	5	from	from	ADP
dti-2469	67	6	string	string	NOUN
dti-2469	67	7	in	in	ADP
dti-2469	67	8	xml	xml	NOUN
dti-2469	67	9	format	format	NOUN
dti-2469	67	10	and	and	CCONJ
dti-2469	67	11	its	its	PRON
dti-2469	67	12	analysis	analysis	NOUN
dti-2469	67	13	was	be	AUX
dti-2469	67	14	done	do	VERB
dti-2469	67	15	using	use	VERB
dti-2469	67	16	cytoscape	cytoscape	NOUN
dti-2469	67	17	(	(	PUNCT
dti-2469	67	18	33	33	NUM
dti-2469	67	19	)	)	PUNCT
dti-2469	67	20	.	.	PUNCT
dti-2469	68	1	in	in	ADP
dti-2469	68	2	cytoscape	cytoscape	NOUN
dti-2469	68	3	,	,	PUNCT
dti-2469	68	4	various	various	ADJ
dti-2469	68	5	critical	critical	ADJ
dti-2469	68	6	network	network	NOUN
dti-2469	68	7	parameters	parameter	NOUN
dti-2469	68	8	such	such	ADJ
dti-2469	68	9	as	as	ADP
dti-2469	68	10	clustering	clustering	ADJ
dti-2469	68	11	coefficient	coefficient	NOUN
dti-2469	68	12	,	,	PUNCT
dti-2469	68	13	characteristic	characteristic	ADJ
dti-2469	68	14	path	path	NOUN
dti-2469	68	15	length	length	NOUN
dti-2469	68	16	and	and	CCONJ
dti-2469	68	17	network	network	NOUN
dti-2469	68	18	centralization	centralization	NOUN
dti-2469	68	19	were	be	AUX
dti-2469	68	20	calculated	calculate	VERB
dti-2469	68	21	for	for	ADP
dti-2469	68	22	each	each	DET
dti-2469	68	23	node	node	NOUN
dti-2469	68	24	of	of	ADP
dti-2469	68	25	the	the	DET
dti-2469	68	26	network	network	NOUN
dti-2469	68	27	.	.	PUNCT
dti-2469	69	1	clustering	cluster	VERB
dti-2469	69	2	coefficient	coefficient	NOUN
dti-2469	69	3	cn	cn	PROPN
dti-2469	69	4	for	for	ADP
dti-2469	69	5	node	node	NOUN
dti-2469	69	6	n	n	CCONJ
dti-2469	69	7	was	be	AUX
dti-2469	69	8	calculated	calculate	VERB
dti-2469	69	9	using	use	VERB
dti-2469	69	10	:	:	PUNCT
dti-2469	69	11	cn	cn	PROPN
dti-2469	69	12	=	=	SYM
dti-2469	69	13	2en	2en	NOUN
dti-2469	69	14	 	 	SPACE
dti-2469	69	15	/k(kn	/k(kn	PUNCT
dti-2469	69	16	–	–	PUNCT
dti-2469	69	17	1	1	NUM
dti-2469	69	18	)	)	PUNCT
dti-2469	69	19	where	where	SCONJ
dti-2469	69	20	en	en	X
dti-2469	69	21	is	be	AUX
dti-2469	69	22	the	the	DET
dti-2469	69	23	number	number	NOUN
dti-2469	69	24	of	of	ADP
dti-2469	69	25	connected	connected	ADJ
dti-2469	69	26	pairs	pair	NOUN
dti-2469	69	27	between	between	ADP
dti-2469	69	28	all	all	DET
dti-2469	69	29	neighbours	neighbour	NOUN
dti-2469	69	30	of	of	ADP
dti-2469	69	31	n	n	PROPN
dti-2469	69	32	and	and	CCONJ
dti-2469	69	33	kn	kn	PROPN
dti-2469	69	34	is	be	AUX
dti-2469	69	35	the	the	DET
dti-2469	69	36	number	number	NOUN
dti-2469	69	37	of	of	ADP
dti-2469	69	38	neighbours	neighbour	NOUN
dti-2469	69	39	.	.	PUNCT
dti-2469	70	1	characteristic	characteristic	ADJ
dti-2469	70	2	path	path	NOUN
dti-2469	70	3	length	length	NOUN
dti-2469	70	4	is	be	AUX
dti-2469	70	5	the	the	DET
dti-2469	70	6	distance	distance	NOUN
dti-2469	70	7	between	between	ADP
dti-2469	70	8	nodes	node	NOUN
dti-2469	70	9	.	.	PUNCT
dti-2469	71	1	network	network	NOUN
dti-2469	71	2	centralization	centralization	NOUN
dti-2469	71	3	is	be	AUX
dti-2469	71	4	the	the	DET
dti-2469	71	5	measure	measure	NOUN
dti-2469	71	6	of	of	ADP
dti-2469	71	7	network	network	NOUN
dti-2469	71	8	association	association	NOUN
dti-2469	71	9	around	around	ADP
dti-2469	71	10	the	the	DET
dti-2469	71	11	central	central	ADJ
dti-2469	71	12	node	node	NOUN
dti-2469	71	13	;	;	PUNCT
dti-2469	71	14	node	node	NOUN
dti-2469	71	15	having	have	VERB
dti-2469	71	16	value	value	NOUN
dti-2469	71	17	close	close	ADV
dti-2469	71	18	to	to	PART
dti-2469	71	19	1	1	NUM
dti-2469	71	20	is	be	AUX
dti-2469	71	21	central	central	ADJ
dti-2469	71	22	to	to	ADP
dti-2469	71	23	network	network	NOUN
dti-2469	71	24	and	and	CCONJ
dti-2469	71	25	value	value	NOUN
dti-2469	71	26	near	near	ADP
dti-2469	71	27	to	to	ADP
dti-2469	71	28	0	0	NUM
dti-2469	71	29	shows	show	VERB
dti-2469	71	30	decentralization	decentralization	NOUN
dti-2469	71	31	.	.	PUNCT
dti-2469	72	1	the	the	DET
dti-2469	72	2	values	value	NOUN
dti-2469	72	3	for	for	ADP
dti-2469	72	4	clustering	clustering	ADJ
dti-2469	72	5	coefficient	coefficient	NOUN
dti-2469	72	6	and	and	CCONJ
dti-2469	72	7	characteristic	characteristic	ADJ
dti-2469	72	8	path	path	NOUN
dti-2469	72	9	length	length	NOUN
dti-2469	72	10	are	be	AUX
dti-2469	72	11	calculated	calculate	VERB
dti-2469	72	12	for	for	ADP
dti-2469	72	13	a	a	DET
dti-2469	72	14	node	node	NOUN
dti-2469	72	15	as	as	ADV
dti-2469	72	16	well	well	ADV
dti-2469	72	17	as	as	ADP
dti-2469	72	18	after	after	ADP
dti-2469	72	19	deleting	delete	VERB
dti-2469	72	20	the	the	DET
dti-2469	72	21	node	node	NOUN
dti-2469	72	22	.	.	PUNCT
dti-2469	73	1	the	the	DET
dti-2469	73	2	difference	difference	NOUN
dti-2469	73	3	in	in	ADP
dti-2469	73	4	these	these	DET
dti-2469	73	5	two	two	NUM
dti-2469	73	6	values	value	NOUN
dti-2469	73	7	shows	show	VERB
dti-2469	73	8	the	the	DET
dti-2469	73	9	impact	impact	NOUN
dti-2469	73	10	of	of	ADP
dti-2469	73	11	node	node	NOUN
dti-2469	73	12	in	in	ADP
dti-2469	73	13	the	the	DET
dti-2469	73	14	network	network	NOUN
dti-2469	73	15	(	(	PUNCT
dti-2469	73	16	33	33	NUM
dti-2469	73	17	)	)	PUNCT
dti-2469	73	18	.	.	PUNCT
dti-2469	74	1	the	the	DET
dti-2469	74	2	complete	complete	ADJ
dti-2469	74	3	methodology	methodology	NOUN
dti-2469	74	4	is	be	AUX
dti-2469	74	5	shown	show	VERB
dti-2469	74	6	in	in	ADP
dti-2469	74	7	figure	figure	NOUN
dti-2469	74	8	1	1	NUM
dti-2469	74	9	.	.	PUNCT
dti-2469	74	10	fig	fig	NOUN
dti-2469	74	11	.	.	PUNCT
dti-2469	75	1	1	1	NUM
dti-2469	75	2	flowchart	flowchart	NOUN
dti-2469	75	3	depicting	depict	VERB
dti-2469	75	4	the	the	DET
dti-2469	75	5	workflow	workflow	NOUN
dti-2469	75	6	of	of	ADP
dti-2469	75	7	the	the	DET
dti-2469	75	8	methodology	methodology	NOUN
dti-2469	75	9	adopted	adopt	VERB
dti-2469	75	10	.	.	PUNCT
dti-2469	76	1	results	result	NOUN
dti-2469	76	2	and	and	CCONJ
dti-2469	76	3	discussion	discussion	VERB
dti-2469	76	4	the	the	DET
dti-2469	76	5	97	97	NUM
dti-2469	76	6	complete	complete	ADJ
dti-2469	76	7	genomes	genome	NOUN
dti-2469	76	8	and	and	CCONJ
dti-2469	76	9	associated	associated	ADJ
dti-2469	76	10	proteomes	proteome	NOUN
dti-2469	76	11	of	of	ADP
dti-2469	76	12	c.	c.	PROPN
dti-2469	76	13	difficile	difficile	VERB
dti-2469	76	14	available	available	ADJ
dti-2469	76	15	till	till	SCONJ
dti-2469	76	16	the	the	DET
dti-2469	76	17	present	present	ADJ
dti-2469	76	18	study	study	NOUN
dti-2469	76	19	were	be	AUX
dti-2469	76	20	downloaded	download	VERB
dti-2469	76	21	from	from	ADP
dti-2469	76	22	the	the	DET
dti-2469	76	23	ncbi	ncbi	NOUN
dti-2469	76	24	.	.	PUNCT
dti-2469	77	1	their	their	PRON
dti-2469	77	2	information	information	NOUN
dti-2469	77	3	such	such	ADJ
dti-2469	77	4	as	as	ADP
dti-2469	77	5	accession	accession	NOUN
dti-2469	77	6	number	number	NOUN
dti-2469	77	7	,	,	PUNCT
dti-2469	77	8	name	name	NOUN
dti-2469	77	9	of	of	ADP
dti-2469	77	10	the	the	DET
dti-2469	77	11	strain	strain	NOUN
dti-2469	77	12	,	,	PUNCT
dti-2469	77	13	country	country	NOUN
dti-2469	77	14	from	from	ADP
dti-2469	77	15	where	where	SCONJ
dti-2469	77	16	isolated	isolated	ADJ
dti-2469	77	17	and	and	CCONJ
dti-2469	77	18	genome	genome	NOUN
dti-2469	77	19	statistics	statistic	NOUN
dti-2469	77	20	is	be	AUX
dti-2469	77	21	provided	provide	VERB
dti-2469	77	22	in	in	ADP
dti-2469	77	23	supplementary	supplementary	ADJ
dti-2469	77	24	file	file	NOUN
dti-2469	77	25	1	1	NUM
dti-2469	77	26	.	.	PUNCT
dti-2469	78	1	the	the	DET
dti-2469	78	2	pangenome	pangenome	NOUN
dti-2469	78	3	analysis	analysis	NOUN
dti-2469	78	4	of	of	ADP
dti-2469	78	5	these	these	DET
dti-2469	78	6	97	97	NUM
dti-2469	78	7	strains	strain	NOUN
dti-2469	78	8	reveals	reveal	VERB
dti-2469	78	9	6,286	6,286	NUM
dti-2469	78	10	gene	gene	NOUN
dti-2469	78	11	families	family	NOUN
dti-2469	78	12	(	(	PUNCT
dti-2469	78	13	pangenome	pangenome	NOUN
dti-2469	78	14	)	)	PUNCT
dti-2469	78	15	,	,	PUNCT
dti-2469	78	16	out	out	ADP
dti-2469	78	17	of	of	ADP
dti-2469	78	18	which	which	PRON
dti-2469	78	19	1,481	1,481	NUM
dti-2469	78	20	are	be	AUX
dti-2469	78	21	core	core	NOUN
dti-2469	78	22	genes	gene	NOUN
dti-2469	78	23	(	(	PUNCT
dti-2469	78	24	present	present	ADJ
dti-2469	78	25	in	in	ADP
dti-2469	78	26	all	all	DET
dti-2469	78	27	species	specie	NOUN
dti-2469	78	28	)	)	PUNCT
dti-2469	78	29	.	.	PUNCT
dti-2469	79	1	thus	thus	ADV
dti-2469	79	2	the	the	DET
dti-2469	79	3	core	core	NOUN
dti-2469	79	4	genes	gene	NOUN
dti-2469	79	5	form	form	VERB
dti-2469	79	6	23.5	23.5	NUM
dti-2469	79	7	%	%	NOUN
dti-2469	79	8	of	of	ADP
dti-2469	79	9	the	the	DET
dti-2469	79	10	total	total	ADJ
dti-2469	79	11	genome	genome	NOUN
dti-2469	79	12	,	,	PUNCT
dti-2469	79	13	which	which	PRON
dti-2469	79	14	signifies	signify	VERB
dti-2469	79	15	a	a	DET
dti-2469	79	16	high	high	ADJ
dti-2469	79	17	genetic	genetic	ADJ
dti-2469	79	18	diversity	diversity	NOUN
dti-2469	79	19	among	among	ADP
dti-2469	79	20	different	different	ADJ
dti-2469	79	21	strains	strain	NOUN
dti-2469	79	22	.	.	PUNCT
dti-2469	80	1	the	the	DET
dti-2469	80	2	same	same	ADJ
dti-2469	80	3	feature	feature	NOUN
dti-2469	80	4	is	be	AUX
dti-2469	80	5	represented	represent	VERB
dti-2469	80	6	in	in	ADP
dti-2469	80	7	core	core	NOUN
dti-2469	80	8	-	-	PUNCT
dti-2469	80	9	pan	pan	NOUN
dti-2469	80	10	genome	genome	NOUN
dti-2469	80	11	plot	plot	NOUN
dti-2469	80	12	(	(	PUNCT
dti-2469	80	13	fig	fig	NOUN
dti-2469	80	14	.	.	PUNCT
dti-2469	81	1	2	2	NUM
dti-2469	81	2	)	)	PUNCT
dti-2469	81	3	.	.	PUNCT
dti-2469	82	1	as	as	SCONJ
dti-2469	82	2	the	the	DET
dti-2469	82	3	genomes	genome	NOUN
dti-2469	82	4	are	be	AUX
dti-2469	82	5	added	add	VERB
dti-2469	82	6	,	,	PUNCT
dti-2469	82	7	the	the	DET
dti-2469	82	8	size	size	NOUN
dti-2469	82	9	of	of	ADP
dti-2469	82	10	pangenome	pangenome	NOUN
dti-2469	82	11	increases	increase	NOUN
dti-2469	82	12	,	,	PUNCT
dti-2469	82	13	whereas	whereas	SCONJ
dti-2469	82	14	the	the	DET
dti-2469	82	15	size	size	NOUN
dti-2469	82	16	of	of	ADP
dti-2469	82	17	core	core	NOUN
dti-2469	82	18	genome	genome	NOUN
dti-2469	82	19	declines	decline	VERB
dti-2469	82	20	.	.	PUNCT
dti-2469	83	1	the	the	DET
dti-2469	83	2	curve	curve	NOUN
dti-2469	83	3	of	of	ADP
dti-2469	83	4	pangenome	pangenome	NOUN
dti-2469	83	5	(	(	PUNCT
dti-2469	83	6	yellow	yellow	ADJ
dti-2469	83	7	colour	colour	NOUN
dti-2469	83	8	)	)	PUNCT
dti-2469	83	9	is	be	AUX
dti-2469	83	10	still	still	ADV
dti-2469	83	11	progressing	progress	VERB
dti-2469	83	12	,	,	PUNCT
dti-2469	83	13	indicating	indicate	VERB
dti-2469	83	14	the	the	DET
dti-2469	83	15	likelihood	likelihood	NOUN
dti-2469	83	16	of	of	ADP
dti-2469	83	17	addition	addition	NOUN
dti-2469	83	18	of	of	ADP
dti-2469	83	19	more	more	ADJ
dti-2469	83	20	genes	gene	NOUN
dti-2469	83	21	,	,	PUNCT
dti-2469	83	22	that	that	ADV
dti-2469	83	23	is	is	ADV
dti-2469	83	24	,	,	PUNCT
dti-2469	83	25	global	global	ADJ
dti-2469	83	26	gene	gene	NOUN
dti-2469	83	27	repertoire	repertoire	NOUN
dti-2469	83	28	is	be	AUX
dti-2469	83	29	likely	likely	ADJ
dti-2469	83	30	to	to	PART
dti-2469	83	31	change	change	VERB
dti-2469	83	32	in	in	ADP
dti-2469	83	33	the	the	DET
dti-2469	83	34	near	near	ADJ
dti-2469	83	35	future	future	NOUN
dti-2469	83	36	and	and	CCONJ
dti-2469	83	37	its	its	PRON
dti-2469	83	38	pangenome	pangenome	NOUN
dti-2469	83	39	is	be	AUX
dti-2469	83	40	almost	almost	ADV
dti-2469	83	41	open	open	ADJ
dti-2469	83	42	.	.	PUNCT
dti-2469	84	1	fig	fig	NOUN
dti-2469	84	2	.	.	PUNCT
dti-2469	85	1	2	2	NUM
dti-2469	85	2	core	core	NOUN
dti-2469	85	3	-	-	PUNCT
dti-2469	85	4	pan	pan	NOUN
dti-2469	85	5	plot	plot	NOUN
dti-2469	85	6	of	of	ADP
dti-2469	85	7	97	97	NUM
dti-2469	85	8	strains	strain	NOUN
dti-2469	85	9	of	of	ADP
dti-2469	85	10	c.	c.	NOUN
dti-2469	85	11	difficile	difficile	NOUN
dti-2469	85	12	genome	genome	NOUN
dti-2469	85	13	.	.	PUNCT
dti-2469	86	1	the	the	DET
dti-2469	86	2	power	power	NOUN
dti-2469	86	3	law	law	PROPN
dti-2469	86	4	regression	regression	NOUN
dti-2469	86	5	model	model	NOUN
dti-2469	86	6	equation	equation	NOUN
dti-2469	86	7	,	,	PUNCT
dti-2469	86	8	f(x	f(x	PROPN
dti-2469	86	9	)	)	PUNCT
dti-2469	87	1	=	=	PUNCT
dti-2469	88	1	a.xb	a.xb	PROPN
dti-2469	88	2	where	where	SCONJ
dti-2469	88	3	f(x	f(x	PROPN
dti-2469	88	4	)	)	PUNCT
dti-2469	88	5	is	be	AUX
dti-2469	88	6	the	the	DET
dti-2469	88	7	pangenome	pangenome	NOUN
dti-2469	88	8	size	size	NOUN
dti-2469	88	9	,	,	PUNCT
dti-2469	88	10	x	x	X
dti-2469	88	11	is	be	AUX
dti-2469	88	12	the	the	DET
dti-2469	88	13	number	number	NOUN
dti-2469	88	14	of	of	ADP
dti-2469	88	15	genomes	genome	NOUN
dti-2469	88	16	used	use	VERB
dti-2469	88	17	,	,	PUNCT
dti-2469	88	18	and	and	CCONJ
dti-2469	88	19	a	a	PRON
dti-2469	88	20	and	and	CCONJ
dti-2469	88	21	b	b	NOUN
dti-2469	88	22	are	be	AUX
dti-2469	88	23	fitting	fitting	ADJ
dti-2469	88	24	parameters	parameter	NOUN
dti-2469	88	25	used	use	VERB
dti-2469	88	26	to	to	PART
dti-2469	88	27	find	find	VERB
dti-2469	88	28	the	the	DET
dti-2469	88	29	openness	openness	NOUN
dti-2469	88	30	and	and	CCONJ
dti-2469	88	31	closeness	closeness	NOUN
dti-2469	88	32	of	of	ADP
dti-2469	88	33	pangenome	pangenome	NOUN
dti-2469	88	34	,	,	PUNCT
dti-2469	88	35	has	have	AUX
dti-2469	88	36	been	be	AUX
dti-2469	88	37	used	use	VERB
dti-2469	88	38	in	in	ADP
dti-2469	88	39	the	the	DET
dti-2469	88	40	present	present	ADJ
dti-2469	88	41	study	study	NOUN
dti-2469	88	42	(	(	PUNCT
dti-2469	88	43	17	17	NUM
dti-2469	88	44	)	)	PUNCT
dti-2469	88	45	.	.	PUNCT
dti-2469	89	1	in	in	ADP
dti-2469	89	2	our	our	PRON
dti-2469	89	3	study	study	NOUN
dti-2469	89	4	with	with	ADP
dti-2469	89	5	c.	c.	NOUN
dti-2469	89	6	difficile	difficile	NOUN
dti-2469	89	7	genes	gene	NOUN
dti-2469	89	8	,	,	PUNCT
dti-2469	89	9	the	the	DET
dti-2469	89	10	values	value	NOUN
dti-2469	89	11	of	of	ADP
dti-2469	89	12	f(x	f(x	PROPN
dti-2469	89	13	)	)	PUNCT
dti-2469	90	1	=	=	PUNCT
dti-2469	90	2	6,286	6,286	NUM
dti-2469	90	3	,	,	PUNCT
dti-2469	90	4	x	x	SYM
dti-2469	90	5	=	=	SYM
dti-2469	90	6	97	97	NUM
dti-2469	90	7	,	,	PUNCT
dti-2469	90	8	a	a	DET
dti-2469	90	9	=	=	SYM
dti-2469	90	10	2687.17	2687.17	NUM
dti-2469	90	11	and	and	CCONJ
dti-2469	90	12	b	b	X
dti-2469	90	13	=	=	NOUN
dti-2469	90	14	0.185459	0.185459	NUM
dti-2469	90	15	indicated	indicate	VERB
dti-2469	90	16	that	that	SCONJ
dti-2469	90	17	the	the	DET
dti-2469	90	18	pangenome	pangenome	NOUN
dti-2469	90	19	is	be	AUX
dti-2469	90	20	open	open	ADJ
dti-2469	90	21	at	at	ADP
dti-2469	90	22	b	b	PROPN
dti-2469	90	23	>	>	X
dti-2469	90	24	0	0	NUM
dti-2469	90	25	;	;	PUNCT
dti-2469	90	26	otherwise	otherwise	ADV
dti-2469	90	27	,	,	PUNCT
dti-2469	90	28	the	the	DET
dti-2469	90	29	pangenome	pangenome	NOUN
dti-2469	90	30	would	would	AUX
dti-2469	90	31	be	be	AUX
dti-2469	90	32	considered	consider	VERB
dti-2469	90	33	to	to	PART
dti-2469	90	34	be	be	AUX
dti-2469	90	35	closed	close	VERB
dti-2469	90	36	.	.	PUNCT
dti-2469	91	1	the	the	DET
dti-2469	91	2	value	value	NOUN
dti-2469	91	3	of	of	ADP
dti-2469	91	4	b	b	NOUN
dti-2469	91	5	=	=	NOUN
dti-2469	91	6	0.185459	0.185459	NUM
dti-2469	91	7	indicates	indicate	VERB
dti-2469	91	8	that	that	SCONJ
dti-2469	91	9	the	the	DET
dti-2469	91	10	pangenome	pangenome	NOUN
dti-2469	91	11	is	be	AUX
dti-2469	91	12	open	open	ADJ
dti-2469	91	13	but	but	CCONJ
dti-2469	91	14	soon	soon	ADV
dti-2469	91	15	may	may	AUX
dti-2469	91	16	be	be	AUX
dti-2469	91	17	closed	close	VERB
dti-2469	91	18	with	with	ADP
dti-2469	91	19	increase	increase	NOUN
dti-2469	91	20	in	in	ADP
dti-2469	91	21	genome	genome	NOUN
dti-2469	91	22	data	datum	NOUN
dti-2469	91	23	.	.	PUNCT
dti-2469	92	1	c.	c.	PROPN
dti-2469	92	2	difficile	difficile	PROPN
dti-2469	92	3	has	have	VERB
dti-2469	92	4	186,308	186,308	NUM
dti-2469	92	5	accessory	accessory	ADJ
dti-2469	92	6	genes	gene	NOUN
dti-2469	92	7	which	which	PRON
dti-2469	92	8	are	be	AUX
dti-2469	92	9	present	present	ADJ
dti-2469	92	10	in	in	ADP
dti-2469	92	11	a	a	DET
dti-2469	92	12	few	few	ADJ
dti-2469	92	13	strains	strain	NOUN
dti-2469	92	14	and	and	CCONJ
dti-2469	92	15	has	have	VERB
dti-2469	92	16	976	976	NUM
dti-2469	92	17	unique	unique	ADJ
dti-2469	92	18	genes	gene	NOUN
dti-2469	92	19	which	which	PRON
dti-2469	92	20	are	be	AUX
dti-2469	92	21	present	present	ADJ
dti-2469	92	22	in	in	ADP
dti-2469	92	23	specific	specific	ADJ
dti-2469	92	24	strains	strain	NOUN
dti-2469	92	25	of	of	ADP
dti-2469	92	26	c.	c.	PROPN
dti-2469	92	27	difficile	difficile	PROPN
dti-2469	92	28	.	.	PUNCT
dti-2469	93	1	the	the	DET
dti-2469	93	2	conservation	conservation	NOUN
dti-2469	93	3	level	level	NOUN
dti-2469	93	4	of	of	ADP
dti-2469	93	5	c.	c.	NOUN
dti-2469	93	6	difficile	difficile	PROPN
dti-2469	93	7	does	do	AUX
dti-2469	93	8	not	not	PART
dti-2469	93	9	seem	seem	VERB
dti-2469	93	10	to	to	PART
dti-2469	93	11	be	be	AUX
dti-2469	93	12	very	very	ADV
dti-2469	93	13	high	high	ADJ
dti-2469	93	14	.	.	PUNCT
dti-2469	94	1	the	the	DET
dti-2469	94	2	genome	genome	NOUN
dti-2469	94	3	level	level	NOUN
dti-2469	94	4	analysis	analysis	NOUN
dti-2469	94	5	reveals	reveal	VERB
dti-2469	94	6	high	high	ADJ
dti-2469	94	7	genetic	genetic	ADJ
dti-2469	94	8	variability	variability	NOUN
dti-2469	94	9	;	;	PUNCT
dti-2469	94	10	this	this	PRON
dti-2469	94	11	may	may	AUX
dti-2469	94	12	be	be	AUX
dti-2469	94	13	due	due	ADJ
dti-2469	94	14	to	to	ADP
dti-2469	94	15	its	its	PRON
dti-2469	94	16	existence	existence	NOUN
dti-2469	94	17	in	in	ADP
dti-2469	94	18	different	different	ADJ
dti-2469	94	19	niches	niche	NOUN
dti-2469	94	20	.	.	PUNCT
dti-2469	95	1	on	on	ADP
dti-2469	95	2	functional	functional	ADJ
dti-2469	95	3	analysis	analysis	NOUN
dti-2469	95	4	,	,	PUNCT
dti-2469	95	5	it	it	PRON
dti-2469	95	6	is	be	AUX
dti-2469	95	7	observed	observe	VERB
dti-2469	95	8	that	that	SCONJ
dti-2469	95	9	unique	unique	ADJ
dti-2469	95	10	genes	gene	NOUN
dti-2469	95	11	(	(	PUNCT
dti-2469	95	12	shown	show	VERB
dti-2469	95	13	in	in	ADP
dti-2469	95	14	blue	blue	ADJ
dti-2469	95	15	)	)	PUNCT
dti-2469	95	16	and	and	CCONJ
dti-2469	95	17	accessory	accessory	NOUN
dti-2469	95	18	genes	gene	NOUN
dti-2469	95	19	(	(	PUNCT
dti-2469	95	20	shown	show	VERB
dti-2469	95	21	in	in	ADP
dti-2469	95	22	red	red	ADJ
dti-2469	95	23	)	)	PUNCT
dti-2469	95	24	are	be	AUX
dti-2469	95	25	mostly	mostly	ADV
dti-2469	95	26	responsible	responsible	ADJ
dti-2469	95	27	for	for	ADP
dti-2469	95	28	metabolism	metabolism	NOUN
dti-2469	95	29	and	and	CCONJ
dti-2469	95	30	transporter	transporter	NOUN
dti-2469	95	31	function	function	NOUN
dti-2469	95	32	(	(	PUNCT
dti-2469	95	33	fig	fig	NOUN
dti-2469	95	34	.	.	PUNCT
dti-2469	96	1	3	3	NUM
dti-2469	96	2	)	)	PUNCT
dti-2469	96	3	.	.	PUNCT
dti-2469	97	1	this	this	PRON
dti-2469	97	2	shows	show	VERB
dti-2469	97	3	that	that	SCONJ
dti-2469	97	4	both	both	PRON
dti-2469	97	5	of	of	ADP
dti-2469	97	6	them	they	PRON
dti-2469	97	7	are	be	AUX
dti-2469	97	8	more	more	ADV
dti-2469	97	9	diversified	diversified	ADJ
dti-2469	97	10	in	in	ADP
dti-2469	97	11	c.	c.	PROPN
dti-2469	97	12	difficile	difficile	PROPN
dti-2469	97	13	.	.	PUNCT
dti-2469	98	1	recently	recently	ADV
dti-2469	98	2	in	in	ADP
dti-2469	98	3	2021	2021	NUM
dti-2469	98	4	,	,	PUNCT
dti-2469	98	5	kulecka	kulecka	PROPN
dti-2469	98	6	et	et	PROPN
dti-2469	98	7	al	al	PROPN
dti-2469	98	8	.	.	PROPN
dti-2469	98	9	also	also	ADV
dti-2469	98	10	reported	report	VERB
dti-2469	98	11	the	the	DET
dti-2469	98	12	variability	variability	NOUN
dti-2469	98	13	in	in	ADP
dti-2469	98	14	the	the	DET
dti-2469	98	15	metabolism	metabolism	NOUN
dti-2469	98	16	genes	gene	NOUN
dti-2469	98	17	in	in	ADP
dti-2469	98	18	recurrent	recurrent	ADJ
dti-2469	98	19	cdi	cdi	PROPN
dti-2469	98	20	cases	case	NOUN
dti-2469	98	21	(	(	PUNCT
dti-2469	98	22	34	34	NUM
dti-2469	98	23	)	)	PUNCT
dti-2469	98	24	.	.	PUNCT
dti-2469	99	1	in	in	ADP
dti-2469	99	2	addition	addition	NOUN
dti-2469	99	3	,	,	PUNCT
dti-2469	99	4	the	the	DET
dti-2469	99	5	core	core	NOUN
dti-2469	99	6	genes	gene	NOUN
dti-2469	99	7	like	like	ADP
dti-2469	99	8	polc	polc	NOUN
dti-2469	99	9	-	-	PUNCT
dti-2469	99	10	type	type	NOUN
dti-2469	99	11	deoxyribonucleic	deoxyribonucleic	ADJ
dti-2469	99	12	acid	acid	NOUN
dti-2469	99	13	(	(	PUNCT
dti-2469	99	14	dna	dna	PROPN
dti-2469	99	15	)	)	PUNCT
dti-2469	99	16	polymerase	polymerase	NOUN
dti-2469	99	17	iii	iii	PROPN
dti-2469	99	18	,	,	PUNCT
dti-2469	99	19	exonuclease	exonuclease	VERB
dti-2469	99	20	subunit	subunit	NOUN
dti-2469	99	21	c	c	NOUN
dti-2469	99	22	,	,	PUNCT
dti-2469	99	23	cell	cell	NOUN
dti-2469	99	24	wall	wall	NOUN
dti-2469	99	25	–	–	PUNCT
dti-2469	99	26	binding	bind	VERB
dti-2469	99	27	protein	protein	NOUN
dti-2469	99	28	cwp20	cwp20	NOUN
dti-2469	99	29	,	,	PUNCT
dti-2469	99	30	sensor	sensor	NOUN
dti-2469	99	31	histidine	histidine	NOUN
dti-2469	99	32	kinase	kinase	PROPN
dti-2469	99	33	kdpd	kdpd	PROPN
dti-2469	99	34	and	and	CCONJ
dti-2469	99	35	alanine	alanine	NOUN
dti-2469	99	36	-	-	PUNCT
dti-2469	99	37	trna	trna	NOUN
dti-2469	99	38	ligase	ligase	NOUN
dti-2469	99	39	(	(	PUNCT
dti-2469	99	40	shown	show	VERB
dti-2469	99	41	in	in	ADP
dti-2469	99	42	green	green	NOUN
dti-2469	99	43	)	)	PUNCT
dti-2469	99	44	are	be	AUX
dti-2469	99	45	the	the	DET
dti-2469	99	46	genes	gene	NOUN
dti-2469	99	47	pangenome	pangenome	NOUN
dti-2469	99	48	analysis	analysis	NOUN
dti-2469	99	49	of	of	ADP
dti-2469	99	50	c.	c.	NOUN
dti-2469	99	51	difficile	difficile	NOUN
dti-2469	99	52	and	and	CCONJ
dti-2469	99	53	drug	drug	NOUN
dti-2469	99	54	target	target	NOUN
dti-2469	99	55	identification20	identification20	NOUN
dti-2469	99	56	©	©	ADP
dti-2469	99	57	2022	2022	NUM
dti-2469	99	58	the	the	DET
dti-2469	99	59	authors	author	NOUN
dti-2469	99	60	.	.	PUNCT
dti-2469	100	1	drug	drug	NOUN
dti-2469	100	2	target	target	NOUN
dti-2469	100	3	insights	insight	NOUN
dti-2469	100	4	issn	issn	VERB
dti-2469	100	5	1177	1177	NUM
dti-2469	100	6	-	-	SYM
dti-2469	100	7	3928	3928	NUM
dti-2469	100	8	www.aboutscience.eu/dti	www.aboutscience.eu/dti	NOUN
dti-2469	100	9	for	for	ADP
dti-2469	100	10	cellular	cellular	ADJ
dti-2469	100	11	processes	process	NOUN
dti-2469	100	12	such	such	ADJ
dti-2469	100	13	as	as	ADP
dti-2469	100	14	cell	cell	NOUN
dti-2469	100	15	division	division	NOUN
dti-2469	100	16	,	,	PUNCT
dti-2469	100	17	cell	cell	NOUN
dti-2469	100	18	cycle	cycle	NOUN
dti-2469	100	19	and	and	CCONJ
dti-2469	100	20	its	its	PRON
dti-2469	100	21	control	control	NOUN
dti-2469	100	22	,	,	PUNCT
dti-2469	100	23	cell	cell	NOUN
dti-2469	100	24	motility	motility	NOUN
dti-2469	100	25	,	,	PUNCT
dti-2469	100	26	cell	cell	NOUN
dti-2469	100	27	wall	wall	NOUN
dti-2469	100	28	/	/	SYM
dti-2469	100	29	membrane	membrane	NOUN
dti-2469	100	30	biogenesis	biogenesis	NOUN
dti-2469	100	31	,	,	PUNCT
dti-2469	100	32	transcription	transcription	NOUN
dti-2469	100	33	,	,	PUNCT
dti-2469	100	34	translation	translation	NOUN
dti-2469	100	35	,	,	PUNCT
dti-2469	100	36	ribosomal	ribosomal	NOUN
dti-2469	100	37	structure	structure	NOUN
dti-2469	100	38	and	and	CCONJ
dti-2469	100	39	biogenesis	biogenesis	NOUN
dti-2469	100	40	,	,	PUNCT
dti-2469	100	41	and	and	CCONJ
dti-2469	100	42	are	be	AUX
dti-2469	100	43	mostly	mostly	ADV
dti-2469	100	44	conserved	conserve	VERB
dti-2469	100	45	.	.	PUNCT
dti-2469	101	1	this	this	PRON
dti-2469	101	2	signifies	signify	VERB
dti-2469	101	3	that	that	SCONJ
dti-2469	101	4	genes	gene	NOUN
dti-2469	101	5	involved	involve	VERB
dti-2469	101	6	in	in	ADP
dti-2469	101	7	important	important	ADJ
dti-2469	101	8	cellular	cellular	ADJ
dti-2469	101	9	mechanism	mechanism	NOUN
dti-2469	101	10	are	be	AUX
dti-2469	101	11	conserved	conserve	VERB
dti-2469	101	12	,	,	PUNCT
dti-2469	101	13	while	while	SCONJ
dti-2469	101	14	genes	gene	NOUN
dti-2469	101	15	required	require	VERB
dti-2469	101	16	to	to	PART
dti-2469	101	17	adapt	adapt	VERB
dti-2469	101	18	to	to	ADP
dti-2469	101	19	the	the	DET
dti-2469	101	20	new	new	ADJ
dti-2469	101	21	ecological	ecological	ADJ
dti-2469	101	22	niches	niche	NOUN
dti-2469	101	23	are	be	AUX
dti-2469	101	24	variable	variable	ADJ
dti-2469	101	25	.	.	PUNCT
dti-2469	102	1	the	the	DET
dti-2469	102	2	pan	pan	NOUN
dti-2469	102	3	-	-	PUNCT
dti-2469	102	4	phylogeny	phylogeny	NOUN
dti-2469	102	5	-	-	PUNCT
dti-2469	102	6	based	base	VERB
dti-2469	102	7	phylogenetic	phylogenetic	ADJ
dti-2469	102	8	tree	tree	NOUN
dti-2469	102	9	is	be	AUX
dti-2469	102	10	shown	show	VERB
dti-2469	102	11	in	in	ADP
dti-2469	102	12	figure	figure	NOUN
dti-2469	102	13	4	4	NUM
dti-2469	102	14	.	.	PUNCT
dti-2469	103	1	it	it	PRON
dti-2469	103	2	is	be	AUX
dti-2469	103	3	observed	observe	VERB
dti-2469	103	4	that	that	SCONJ
dti-2469	103	5	strains	strain	NOUN
dti-2469	103	6	are	be	AUX
dti-2469	103	7	divided	divide	VERB
dti-2469	103	8	into	into	ADP
dti-2469	103	9	different	different	ADJ
dti-2469	103	10	clades	clade	NOUN
dti-2469	103	11	based	base	VERB
dti-2469	103	12	on	on	ADP
dti-2469	103	13	genome	genome	NOUN
dti-2469	103	14	similarity	similarity	NOUN
dti-2469	103	15	.	.	PUNCT
dti-2469	104	1	on	on	ADP
dti-2469	104	2	observing	observe	VERB
dti-2469	104	3	each	each	DET
dti-2469	104	4	clade	clade	NOUN
dti-2469	104	5	,	,	PUNCT
dti-2469	104	6	it	it	PRON
dti-2469	104	7	is	be	AUX
dti-2469	104	8	noticed	notice	VERB
dti-2469	104	9	that	that	SCONJ
dti-2469	104	10	similarity	similarity	NOUN
dti-2469	104	11	is	be	AUX
dti-2469	104	12	mainly	mainly	ADV
dti-2469	104	13	based	base	VERB
dti-2469	104	14	on	on	ADP
dti-2469	104	15	the	the	DET
dti-2469	104	16	country	country	NOUN
dti-2469	104	17	from	from	ADP
dti-2469	104	18	where	where	SCONJ
dti-2469	104	19	the	the	DET
dti-2469	104	20	samples	sample	NOUN
dti-2469	104	21	are	be	AUX
dti-2469	104	22	isolated	isolate	VERB
dti-2469	104	23	.	.	PUNCT
dti-2469	105	1	it	it	PRON
dti-2469	105	2	suggests	suggest	VERB
dti-2469	105	3	that	that	SCONJ
dti-2469	105	4	c.	c.	PROPN
dti-2469	105	5	difficile	difficile	NOUN
dti-2469	105	6	adapts	adapt	VERB
dti-2469	105	7	to	to	ADP
dti-2469	105	8	different	different	ADJ
dti-2469	105	9	environmental	environmental	ADJ
dti-2469	105	10	conditions	condition	NOUN
dti-2469	105	11	by	by	ADP
dti-2469	105	12	expression	expression	NOUN
dti-2469	105	13	of	of	ADP
dti-2469	105	14	relative	relative	ADJ
dti-2469	105	15	proportions	proportion	NOUN
dti-2469	105	16	of	of	ADP
dti-2469	105	17	the	the	DET
dti-2469	105	18	different	different	ADJ
dti-2469	105	19	gene	gene	NOUN
dti-2469	105	20	products	product	NOUN
dti-2469	105	21	.	.	PUNCT
dti-2469	106	1	for	for	ADP
dti-2469	106	2	example	example	NOUN
dti-2469	106	3	,	,	PUNCT
dti-2469	106	4	strains	strain	NOUN
dti-2469	106	5	cd9	cd9	NOUN
dti-2469	106	6	,	,	PUNCT
dti-2469	106	7	cd12	cd12	PROPN
dti-2469	106	8	,	,	PUNCT
dti-2469	106	9	mt5121	mt5121	ADJ
dti-2469	106	10	,	,	PUNCT
dti-2469	106	11	cd23	cd23	PROPN
dti-2469	106	12	and	and	CCONJ
dti-2469	106	13	w0023a	w0023a	NOUN
dti-2469	106	14	are	be	AUX
dti-2469	106	15	all	all	PRON
dti-2469	106	16	assembled	assemble	VERB
dti-2469	106	17	in	in	ADP
dti-2469	106	18	one	one	NUM
dti-2469	106	19	clade	clade	NOUN
dti-2469	106	20	and	and	CCONJ
dti-2469	106	21	are	be	AUX
dti-2469	106	22	isolated	isolate	VERB
dti-2469	106	23	from	from	ADP
dti-2469	106	24	the	the	DET
dti-2469	106	25	usa	usa	PROPN
dti-2469	106	26	.	.	PROPN
dti-2469	107	1	similarly	similarly	ADV
dti-2469	107	2	strains	strain	VERB
dti-2469	107	3	cd-10	cd-10	NOUN
dti-2469	107	4	-	-	PUNCT
dti-2469	107	5	00484	00484	NUM
dti-2469	107	6	,	,	PUNCT
dti-2469	107	7	10	10	NUM
dti-2469	107	8	-	-	SYM
dti-2469	107	9	00078	00078	NUM
dti-2469	107	10	,	,	PUNCT
dti-2469	107	11	dsm	dsm	PROPN
dti-2469	107	12	102860	102860	NUM
dti-2469	107	13	,	,	PUNCT
dti-2469	107	14	dsm	dsm	PROPN
dti-2469	107	15	102978	102978	NUM
dti-2469	107	16	and	and	CCONJ
dti-2469	107	17	dsm	dsm	PROPN
dti-2469	107	18	29745	29745	NUM
dti-2469	107	19	isolated	isolate	VERB
dti-2469	107	20	from	from	ADP
dti-2469	107	21	germany	germany	PROPN
dti-2469	107	22	show	show	NOUN
dti-2469	107	23	genome	genome	NOUN
dti-2469	107	24	similarity	similarity	NOUN
dti-2469	107	25	and	and	CCONJ
dti-2469	107	26	are	be	AUX
dti-2469	107	27	assembled	assemble	VERB
dti-2469	107	28	in	in	ADP
dti-2469	107	29	one	one	NUM
dti-2469	107	30	clade	clade	NOUN
dti-2469	107	31	.	.	PUNCT
dti-2469	108	1	with	with	ADP
dti-2469	108	2	high	high	ADJ
dti-2469	108	3	genetic	genetic	ADJ
dti-2469	108	4	variability	variability	NOUN
dti-2469	108	5	and	and	CCONJ
dti-2469	108	6	drug	drug	NOUN
dti-2469	108	7	resistance	resistance	NOUN
dti-2469	108	8	for	for	ADP
dti-2469	108	9	cdi	cdi	PROPN
dti-2469	108	10	,	,	PUNCT
dti-2469	108	11	it	it	PRON
dti-2469	108	12	is	be	AUX
dti-2469	108	13	very	very	ADV
dti-2469	108	14	necessary	necessary	ADJ
dti-2469	108	15	to	to	PART
dti-2469	108	16	design	design	VERB
dti-2469	108	17	a	a	DET
dti-2469	108	18	drug	drug	NOUN
dti-2469	108	19	that	that	PRON
dti-2469	108	20	targets	target	VERB
dti-2469	108	21	the	the	DET
dti-2469	108	22	core	core	NOUN
dti-2469	108	23	genes	gene	NOUN
dti-2469	108	24	of	of	ADP
dti-2469	108	25	the	the	DET
dti-2469	108	26	pathogen	pathogen	NOUN
dti-2469	108	27	,	,	PUNCT
dti-2469	108	28	as	as	SCONJ
dti-2469	108	29	core	core	NOUN
dti-2469	108	30	genes	gene	NOUN
dti-2469	108	31	are	be	AUX
dti-2469	108	32	present	present	ADJ
dti-2469	108	33	in	in	ADP
dti-2469	108	34	all	all	DET
dti-2469	108	35	the	the	DET
dti-2469	108	36	strains	strain	NOUN
dti-2469	108	37	of	of	ADP
dti-2469	108	38	the	the	DET
dti-2469	108	39	pathogen	pathogen	NOUN
dti-2469	108	40	and	and	CCONJ
dti-2469	108	41	are	be	AUX
dti-2469	108	42	essential	essential	ADJ
dti-2469	108	43	for	for	ADP
dti-2469	108	44	the	the	DET
dti-2469	108	45	survival	survival	NOUN
dti-2469	108	46	of	of	ADP
dti-2469	108	47	the	the	DET
dti-2469	108	48	pathogen	pathogen	NOUN
dti-2469	108	49	.	.	PUNCT
dti-2469	109	1	therefore	therefore	ADV
dti-2469	109	2	,	,	PUNCT
dti-2469	109	3	targeting	target	VERB
dti-2469	109	4	core	core	NOUN
dti-2469	109	5	gene	gene	NOUN
dti-2469	109	6	will	will	AUX
dti-2469	109	7	surely	surely	ADV
dti-2469	109	8	help	help	VERB
dti-2469	109	9	to	to	PART
dti-2469	109	10	overcome	overcome	VERB
dti-2469	109	11	cdi	cdi	PROPN
dti-2469	109	12	.	.	PUNCT
dti-2469	110	1	we	we	PRON
dti-2469	110	2	have	have	AUX
dti-2469	110	3	used	use	VERB
dti-2469	110	4	an	an	DET
dti-2469	110	5	integrative	integrative	ADJ
dti-2469	110	6	approach	approach	NOUN
dti-2469	110	7	based	base	VERB
dti-2469	110	8	on	on	ADP
dti-2469	110	9	sequence	sequence	NOUN
dti-2469	110	10	and	and	CCONJ
dti-2469	110	11	interactome	interactome	NOUN
dti-2469	110	12	analysis	analysis	NOUN
dti-2469	110	13	to	to	PART
dti-2469	110	14	find	find	VERB
dti-2469	110	15	the	the	DET
dti-2469	110	16	drug	drug	NOUN
dti-2469	110	17	target	target	NOUN
dti-2469	110	18	against	against	ADP
dti-2469	110	19	c.	c.	PROPN
dti-2469	110	20	difficile	difficile	PROPN
dti-2469	110	21	.	.	PUNCT
dti-2469	111	1	from	from	ADP
dti-2469	111	2	the	the	DET
dti-2469	111	3	core	core	NOUN
dti-2469	111	4	genome	genome	NOUN
dti-2469	111	5	,	,	PUNCT
dti-2469	111	6	genes	gene	NOUN
dti-2469	111	7	that	that	PRON
dti-2469	111	8	are	be	AUX
dti-2469	111	9	homologous	homologous	ADJ
dti-2469	111	10	to	to	ADP
dti-2469	111	11	humans	human	NOUN
dti-2469	111	12	are	be	AUX
dti-2469	111	13	excluded	exclude	VERB
dti-2469	111	14	in	in	ADP
dti-2469	111	15	the	the	DET
dti-2469	111	16	first	first	ADJ
dti-2469	111	17	step	step	NOUN
dti-2469	111	18	,	,	PUNCT
dti-2469	111	19	as	as	SCONJ
dti-2469	111	20	it	it	PRON
dti-2469	111	21	may	may	AUX
dti-2469	111	22	adversely	adversely	ADV
dti-2469	111	23	affect	affect	VERB
dti-2469	111	24	the	the	DET
dti-2469	111	25	host	host	NOUN
dti-2469	111	26	metabolism	metabolism	NOUN
dti-2469	111	27	.	.	PUNCT
dti-2469	112	1	a	a	DET
dti-2469	112	2	total	total	NOUN
dti-2469	112	3	of	of	ADP
dti-2469	112	4	1,130	1,130	NUM
dti-2469	112	5	proteins	protein	NOUN
dti-2469	112	6	are	be	AUX
dti-2469	112	7	found	find	VERB
dti-2469	112	8	to	to	PART
dti-2469	112	9	be	be	AUX
dti-2469	112	10	non	non	ADJ
dti-2469	112	11	-	-	ADJ
dti-2469	112	12	homologous	homologous	ADJ
dti-2469	112	13	to	to	ADP
dti-2469	112	14	human	human	NOUN
dti-2469	112	15	(	(	PUNCT
dti-2469	112	16	supplementary	supplementary	ADJ
dti-2469	112	17	file	file	NOUN
dti-2469	112	18	2	2	NUM
dti-2469	112	19	)	)	PUNCT
dti-2469	112	20	.	.	PUNCT
dti-2469	113	1	on	on	ADP
dti-2469	113	2	further	further	ADJ
dti-2469	113	3	screening	screening	NOUN
dti-2469	113	4	,	,	PUNCT
dti-2469	113	5	essential	essential	ADJ
dti-2469	113	6	proteins	protein	NOUN
dti-2469	113	7	that	that	PRON
dti-2469	113	8	are	be	AUX
dti-2469	113	9	vital	vital	ADJ
dti-2469	113	10	for	for	SCONJ
dti-2469	113	11	the	the	DET
dti-2469	113	12	survival	survival	NOUN
dti-2469	113	13	of	of	ADP
dti-2469	113	14	pathogens	pathogen	NOUN
dti-2469	113	15	are	be	AUX
dti-2469	113	16	searched	search	VERB
dti-2469	113	17	using	use	VERB
dti-2469	113	18	deg	deg	NOUN
dti-2469	113	19	.	.	PUNCT
dti-2469	114	1	among	among	ADP
dti-2469	114	2	them	they	PRON
dti-2469	114	3	,	,	PUNCT
dti-2469	114	4	370	370	NUM
dti-2469	114	5	proteins	protein	NOUN
dti-2469	114	6	were	be	AUX
dti-2469	114	7	found	find	VERB
dti-2469	114	8	to	to	PART
dti-2469	114	9	be	be	AUX
dti-2469	114	10	essential	essential	ADJ
dti-2469	114	11	and	and	CCONJ
dti-2469	114	12	crucial	crucial	ADJ
dti-2469	114	13	for	for	ADP
dti-2469	114	14	c.	c.	PROPN
dti-2469	114	15	difficile	difficile	PROPN
dti-2469	114	16	survival	survival	NOUN
dti-2469	114	17	(	(	PUNCT
dti-2469	114	18	supplementary	supplementary	ADJ
dti-2469	114	19	file	file	NOUN
dti-2469	114	20	2	2	NUM
dti-2469	114	21	)	)	PUNCT
dti-2469	114	22	.	.	PUNCT
dti-2469	115	1	essential	essential	ADJ
dti-2469	115	2	proteins	protein	NOUN
dti-2469	115	3	were	be	AUX
dti-2469	115	4	further	far	ADV
dti-2469	115	5	screened	screen	VERB
dti-2469	115	6	for	for	ADP
dti-2469	115	7	their	their	PRON
dti-2469	115	8	virulence	virulence	NOUN
dti-2469	115	9	,	,	PUNCT
dti-2469	115	10	as	as	SCONJ
dti-2469	115	11	these	these	DET
dti-2469	115	12	factors	factor	NOUN
dti-2469	115	13	are	be	AUX
dti-2469	115	14	responsible	responsible	ADJ
dti-2469	115	15	for	for	ADP
dti-2469	115	16	pathogenesis	pathogenesis	NOUN
dti-2469	115	17	.	.	PUNCT
dti-2469	116	1	from	from	ADP
dti-2469	116	2	370	370	NUM
dti-2469	116	3	essential	essential	ADJ
dti-2469	116	4	proteins	protein	NOUN
dti-2469	116	5	,	,	PUNCT
dti-2469	116	6	130	130	NUM
dti-2469	116	7	proteins	protein	NOUN
dti-2469	116	8	were	be	AUX
dti-2469	116	9	found	find	VERB
dti-2469	116	10	to	to	PART
dti-2469	116	11	be	be	AUX
dti-2469	116	12	virulence	virulence	NOUN
dti-2469	116	13	-	-	PUNCT
dti-2469	116	14	associated	associate	VERB
dti-2469	116	15	factors	factor	NOUN
dti-2469	116	16	(	(	PUNCT
dti-2469	116	17	supplementary	supplementary	ADJ
dti-2469	116	18	file	file	NOUN
dti-2469	116	19	2	2	NUM
dti-2469	116	20	)	)	PUNCT
dti-2469	116	21	.	.	PUNCT
dti-2469	117	1	all	all	DET
dti-2469	117	2	130	130	NUM
dti-2469	117	3	proteins	protein	NOUN
dti-2469	117	4	were	be	AUX
dti-2469	117	5	checked	check	VERB
dti-2469	117	6	for	for	ADP
dti-2469	117	7	their	their	PRON
dti-2469	117	8	physicochemical	physicochemical	ADJ
dti-2469	117	9	properties	property	NOUN
dti-2469	117	10	.	.	PUNCT
dti-2469	118	1	proteins	protein	NOUN
dti-2469	118	2	having	have	VERB
dti-2469	118	3	more	more	ADJ
dti-2469	118	4	than	than	ADP
dti-2469	118	5	100	100	NUM
dti-2469	118	6	amino	amino	ADJ
dti-2469	118	7	acids	acid	NOUN
dti-2469	118	8	,	,	PUNCT
dti-2469	118	9	less	less	ADV
dti-2469	118	10	molecular	molecular	ADJ
dti-2469	118	11	weight	weight	NOUN
dti-2469	118	12	,	,	PUNCT
dti-2469	118	13	low	low	ADJ
dti-2469	118	14	pi	pi	NOUN
dti-2469	118	15	,	,	PUNCT
dti-2469	118	16	negative	negative	ADJ
dti-2469	118	17	gravy	gravy	NOUN
dti-2469	118	18	value	value	NOUN
dti-2469	118	19	,	,	PUNCT
dti-2469	118	20	high	high	ADJ
dti-2469	118	21	aliphatic	aliphatic	ADJ
dti-2469	118	22	index	index	NOUN
dti-2469	118	23	and	and	CCONJ
dti-2469	118	24	membrane	membrane	NOUN
dti-2469	118	25	or	or	CCONJ
dti-2469	118	26	cytoplasmic	cytoplasmic	ADJ
dti-2469	118	27	localization	localization	NOUN
dti-2469	118	28	were	be	AUX
dti-2469	118	29	further	far	ADV
dti-2469	118	30	considered	consider	VERB
dti-2469	118	31	(	(	PUNCT
dti-2469	118	32	26	26	NUM
dti-2469	118	33	-	-	SYM
dti-2469	118	34	30	30	NUM
dti-2469	118	35	)	)	PUNCT
dti-2469	118	36	.	.	PUNCT
dti-2469	119	1	all	all	DET
dti-2469	119	2	these	these	PRON
dti-2469	119	3	are	be	AUX
dti-2469	119	4	the	the	DET
dti-2469	119	5	physicochemical	physicochemical	ADJ
dti-2469	119	6	properties	property	NOUN
dti-2469	119	7	required	require	VERB
dti-2469	119	8	for	for	ADP
dti-2469	119	9	the	the	DET
dti-2469	119	10	potent	potent	ADJ
dti-2469	119	11	drug	drug	NOUN
dti-2469	119	12	target	target	NOUN
dti-2469	119	13	.	.	PUNCT
dti-2469	120	1	a	a	DET
dti-2469	120	2	total	total	NOUN
dti-2469	120	3	of	of	ADP
dti-2469	120	4	94	94	NUM
dti-2469	120	5	proteins	protein	NOUN
dti-2469	120	6	were	be	AUX
dti-2469	120	7	obtained	obtain	VERB
dti-2469	120	8	after	after	ADP
dti-2469	120	9	all	all	DET
dti-2469	120	10	physicochemical	physicochemical	ADJ
dti-2469	120	11	checks	check	NOUN
dti-2469	120	12	(	(	PUNCT
dti-2469	120	13	supplementary	supplementary	ADJ
dti-2469	120	14	file	file	NOUN
dti-2469	120	15	2	2	NUM
dti-2469	120	16	)	)	PUNCT
dti-2469	120	17	;	;	PUNCT
dti-2469	120	18	they	they	PRON
dti-2469	120	19	are	be	AUX
dti-2469	120	20	further	far	ADV
dti-2469	120	21	used	use	VERB
dti-2469	120	22	for	for	ADP
dti-2469	120	23	choke	choke	NOUN
dti-2469	120	24	point	point	NOUN
dti-2469	120	25	analysis	analysis	NOUN
dti-2469	120	26	.	.	PUNCT
dti-2469	121	1	on	on	ADP
dti-2469	121	2	choke	choke	NOUN
dti-2469	121	3	point	point	NOUN
dti-2469	121	4	analysis	analysis	NOUN
dti-2469	121	5	,	,	PUNCT
dti-2469	121	6	only	only	ADV
dti-2469	121	7	39	39	NUM
dti-2469	121	8	proteins	protein	NOUN
dti-2469	121	9	involved	involve	VERB
dti-2469	121	10	in	in	ADP
dti-2469	121	11	the	the	DET
dti-2469	121	12	unique	unique	ADJ
dti-2469	121	13	metabolic	metabolic	NOUN
dti-2469	121	14	pathways	pathway	NOUN
dti-2469	121	15	were	be	AUX
dti-2469	121	16	identified	identify	VERB
dti-2469	121	17	(	(	PUNCT
dti-2469	121	18	supplementary	supplementary	ADJ
dti-2469	121	19	file	file	NOUN
dti-2469	121	20	2	2	NUM
dti-2469	121	21	)	)	PUNCT
dti-2469	121	22	.	.	PUNCT
dti-2469	122	1	for	for	ADP
dti-2469	122	2	these	these	DET
dti-2469	122	3	39	39	NUM
dti-2469	122	4	proteins	protein	NOUN
dti-2469	122	5	,	,	PUNCT
dti-2469	122	6	interactome	interactome	NOUN
dti-2469	122	7	is	be	AUX
dti-2469	122	8	created	create	VERB
dti-2469	122	9	using	use	VERB
dti-2469	122	10	string	string	NOUN
dti-2469	122	11	as	as	SCONJ
dti-2469	122	12	shown	show	VERB
dti-2469	122	13	in	in	ADP
dti-2469	122	14	figure	figure	NOUN
dti-2469	122	15	5	5	NUM
dti-2469	122	16	.	.	PUNCT
dti-2469	123	1	on	on	ADP
dti-2469	123	2	interactome	interactome	NOUN
dti-2469	123	3	analysis	analysis	NOUN
dti-2469	123	4	with	with	ADP
dti-2469	123	5	cytoscape	cytoscape	NOUN
dti-2469	123	6	,	,	PUNCT
dti-2469	123	7	eight	eight	NUM
dti-2469	123	8	potent	potent	ADJ
dti-2469	123	9	drug	drug	NOUN
dti-2469	123	10	targets	target	NOUN
dti-2469	123	11	were	be	AUX
dti-2469	123	12	found	find	VERB
dti-2469	123	13	.	.	PUNCT
dti-2469	124	1	their	their	PRON
dti-2469	124	2	interactome	interactome	NOUN
dti-2469	124	3	analysis	analysis	NOUN
dti-2469	124	4	fig	fig	NOUN
dti-2469	124	5	.	.	PUNCT
dti-2469	125	1	3	3	NUM
dti-2469	125	2	functional	functional	ADJ
dti-2469	125	3	analysis	analysis	NOUN
dti-2469	125	4	of	of	ADP
dti-2469	125	5	various	various	ADJ
dti-2469	125	6	core	core	NOUN
dti-2469	125	7	,	,	PUNCT
dti-2469	125	8	accessory	accessory	NOUN
dti-2469	125	9	and	and	CCONJ
dti-2469	125	10	unique	unique	ADJ
dti-2469	125	11	genes	gene	NOUN
dti-2469	125	12	using	use	VERB
dti-2469	125	13	cog	cog	PROPN
dti-2469	125	14	and	and	CCONJ
dti-2469	125	15	kegg	kegg	NOUN
dti-2469	125	16	distributions	distribution	NOUN
dti-2469	125	17	.	.	PUNCT
dti-2469	126	1	golchha	golchha	PROPN
dti-2469	126	2	et	et	PROPN
dti-2469	126	3	al	al	PROPN
dti-2469	126	4	drug	drug	PROPN
dti-2469	126	5	target	target	NOUN
dti-2469	126	6	insights	insight	NOUN
dti-2469	126	7	2022	2022	NUM
dti-2469	126	8	;	;	PUNCT
dti-2469	126	9	16	16	NUM
dti-2469	126	10	:	:	SYM
dti-2469	126	11	21	21	NUM
dti-2469	126	12	©	©	PROPN
dti-2469	126	13	2022	2022	NUM
dti-2469	126	14	the	the	DET
dti-2469	126	15	authors	author	NOUN
dti-2469	126	16	.	.	PUNCT
dti-2469	127	1	published	publish	VERB
dti-2469	127	2	by	by	ADP
dti-2469	127	3	aboutscience	aboutscience	NOUN
dti-2469	127	4	www.aboutscience.eu	www.aboutscience.eu	NOUN
dti-2469	127	5	fig	fig	NOUN
dti-2469	127	6	.	.	PUNCT
dti-2469	128	1	4	4	NUM
dti-2469	128	2	pan	pan	NOUN
dti-2469	128	3	phylogeny	phylogeny	NOUN
dti-2469	128	4	–	–	PUNCT
dti-2469	128	5	based	base	VERB
dti-2469	128	6	phylogenetic	phylogenetic	ADJ
dti-2469	128	7	tree	tree	NOUN
dti-2469	128	8	of	of	ADP
dti-2469	128	9	97	97	NUM
dti-2469	128	10	strains	strain	NOUN
dti-2469	128	11	of	of	ADP
dti-2469	128	12	c.	c.	PROPN
dti-2469	128	13	difficile	difficile	PROPN
dti-2469	128	14	.	.	PUNCT
dti-2469	129	1	fig	fig	NOUN
dti-2469	129	2	.	.	PUNCT
dti-2469	130	1	5	5	NUM
dti-2469	130	2	a	a	PRON
dti-2469	130	3	)	)	PUNCT
dti-2469	130	4	interactome	interactome	NOUN
dti-2469	130	5	created	create	VERB
dti-2469	130	6	using	use	VERB
dti-2469	130	7	string	string	NOUN
dti-2469	130	8	.	.	PUNCT
dti-2469	131	1	b	b	X
dti-2469	131	2	)	)	PUNCT
dti-2469	131	3	zoomed	zoomed	ADJ
dti-2469	131	4	view	view	NOUN
dti-2469	131	5	of	of	ADP
dti-2469	131	6	interactome	interactome	NOUN
dti-2469	131	7	.	.	PUNCT
dti-2469	132	1	pangenome	pangenome	NOUN
dti-2469	132	2	analysis	analysis	NOUN
dti-2469	132	3	of	of	ADP
dti-2469	132	4	c.	c.	NOUN
dti-2469	132	5	difficile	difficile	NOUN
dti-2469	132	6	and	and	CCONJ
dti-2469	132	7	drug	drug	NOUN
dti-2469	132	8	target	target	NOUN
dti-2469	132	9	identification22	identification22	NOUN
dti-2469	133	1	©	©	ADP
dti-2469	133	2	2022	2022	NUM
dti-2469	134	1	the	the	DET
dti-2469	134	2	authors	author	NOUN
dti-2469	134	3	.	.	PUNCT
dti-2469	135	1	drug	drug	NOUN
dti-2469	135	2	target	target	NOUN
dti-2469	135	3	insights	insight	NOUN
dti-2469	135	4	issn	issn	VERB
dti-2469	135	5	1177	1177	NUM
dti-2469	135	6	-	-	SYM
dti-2469	135	7	3928	3928	NUM
dti-2469	135	8	www.aboutscience.eu/dti	www.aboutscience.eu/dti	NOUN
dti-2469	135	9	table	table	NOUN
dti-2469	135	10	i	i	PRON
dti-2469	135	11	interactome	interactome	VERB
dti-2469	135	12	analysis	analysis	NOUN
dti-2469	135	13	of	of	ADP
dti-2469	135	14	potent	potent	ADJ
dti-2469	135	15	eight	eight	NUM
dti-2469	135	16	drug	drug	NOUN
dti-2469	135	17	targets	target	NOUN
dti-2469	135	18	sl	sl	VERB
dti-2469	135	19	.	.	PUNCT
dti-2469	136	1	no	no	DET
dti-2469	136	2	sequence	sequence	NOUN
dti-2469	136	3	no	no	INTJ
dti-2469	136	4	.	.	PUNCT
dti-2469	137	1	target	target	NOUN
dti-2469	137	2	name	name	NOUN
dti-2469	137	3	clustering	cluster	VERB
dti-2469	137	4	coefficient	coefficient	ADJ
dti-2469	137	5	characteristic	characteristic	ADJ
dti-2469	137	6	path	path	NOUN
dti-2469	137	7	length	length	PROPN
dti-2469	137	8	network	network	PROPN
dti-2469	137	9	centralizationbefore	centralizationbefore	PROPN
dti-2469	137	10	n.d	n.d	PROPN
dti-2469	137	11	.	.	PROPN
dti-2469	138	1	after	after	ADP
dti-2469	138	2	n.d	n.d	PROPN
dti-2469	138	3	.	.	PROPN
dti-2469	138	4	before	before	ADP
dti-2469	138	5	n.d	n.d	PROPN
dti-2469	138	6	.	.	PROPN
dti-2469	139	1	after	after	ADP
dti-2469	139	2	n.d	n.d	PROPN
dti-2469	139	3	.	.	PROPN
dti-2469	139	4	1	1	NUM
dti-2469	139	5	.	.	PUNCT
dti-2469	140	1	org18_gene1417	org18_gene1417	ADJ
dti-2469	140	2	aminodeoxychorismate	aminodeoxychorismate	ADJ
dti-2469	140	3	synthase	synthase	NOUN
dti-2469	140	4	(	(	PUNCT
dti-2469	140	5	pabb	pabb	NOUN
dti-2469	140	6	)	)	PUNCT
dti-2469	140	7	0.666	0.666	NUM
dti-2469	140	8	0.397	0.397	NUM
dti-2469	140	9	3.98	3.98	NUM
dti-2469	140	10	2.76	2.76	NUM
dti-2469	140	11	0.325	0.325	NUM
dti-2469	140	12	2	2	NUM
dti-2469	140	13	.	.	PUNCT
dti-2469	141	1	org18_gene1870	org18_gene1870	ADJ
dti-2469	141	2	bifunctional	bifunctional	ADJ
dti-2469	141	3	diguanylate	diguanylate	ADJ
dti-2469	141	4	cyclase/	cyclase/	NUM
dti-2469	141	5	phosphodiesterase	phosphodiesterase	NOUN
dti-2469	141	6	(	(	PUNCT
dti-2469	141	7	cyclic	cyclic	NOUN
dti-2469	141	8	-	-	PUNCT
dti-2469	141	9	digmp	digmp	NOUN
dti-2469	141	10	)	)	PUNCT
dti-2469	141	11	0.863	0.863	NUM
dti-2469	141	12	0.425	0.425	NUM
dti-2469	141	13	2.36	2.36	NUM
dti-2469	141	14	1.83	1.83	NUM
dti-2469	141	15	0.693	0.693	NUM
dti-2469	141	16	3	3	NUM
dti-2469	141	17	.	.	PUNCT
dti-2469	142	1	org11_gene1255	org11_gene1255	PROPN
dti-2469	142	2	sporulation	sporulation	NOUN
dti-2469	142	3	transcription	transcription	NOUN
dti-2469	142	4	factor	factor	NOUN
dti-2469	142	5	(	(	PUNCT
dti-2469	142	6	spo0a	spo0a	PROPN
dti-2469	142	7	)	)	PUNCT
dti-2469	142	8	0.99	0.99	NUM
dti-2469	142	9	0.725	0.725	NUM
dti-2469	142	10	3.26	3.26	NUM
dti-2469	142	11	2.98	2.98	NUM
dti-2469	142	12	0.523	0.523	NUM
dti-2469	142	13	4	4	NUM
dti-2469	142	14	.	.	PUNCT
dti-2469	143	1	org39_gene1501	org39_gene1501	VERB
dti-2469	143	2	histidinol	histidinol	ADJ
dti-2469	143	3	-	-	PUNCT
dti-2469	143	4	phosphate	phosphate	NOUN
dti-2469	143	5	transaminase	transaminase	NOUN
dti-2469	143	6	(	(	PUNCT
dti-2469	143	7	hisc	hisc	NOUN
dti-2469	143	8	)	)	PUNCT
dti-2469	143	9	0.356	0.356	NUM
dti-2469	143	10	0.120	0.120	NUM
dti-2469	143	11	2.35	2.35	NUM
dti-2469	143	12	1.25	1.25	NUM
dti-2469	143	13	0.364	0.364	NUM
dti-2469	143	14	5	5	NUM
dti-2469	143	15	.	.	PUNCT
dti-2469	144	1	org82_gene1721	org82_gene1721	PROPN
dti-2469	144	2	3	3	NUM
dti-2469	144	3	-	-	PUNCT
dti-2469	144	4	deoxy-7	deoxy-7	NOUN
dti-2469	144	5	-	-	PUNCT
dti-2469	144	6	phosphoheptulonate	phosphoheptulonate	ADJ
dti-2469	144	7	synthase	synthase	NOUN
dti-2469	144	8	(	(	PUNCT
dti-2469	144	9	dahp	dahp	NOUN
dti-2469	144	10	synthase	synthase	NOUN
dti-2469	144	11	)	)	PUNCT
dti-2469	144	12	0.70	0.70	NUM
dti-2469	144	13	0.530	0.530	NUM
dti-2469	144	14	3.29	3.29	NUM
dti-2469	144	15	2.98	2.98	NUM
dti-2469	144	16	0.452	0.452	NUM
dti-2469	144	17	6	6	NUM
dti-2469	144	18	.	.	PUNCT
dti-2469	145	1	org18_gene2684	org18_gene2684	PRON
dti-2469	145	2	undecaprenyl	undecaprenyl	NOUN
dti-2469	145	3	diphospho	diphospho	VERB
dti-2469	145	4	-	-	PUNCT
dti-2469	145	5	muramoyl	muramoyl	ADJ
dti-2469	145	6	pentapeptide	pentapeptide	NOUN
dti-2469	145	7	beta	beta	NOUN
dti-2469	145	8	-	-	PUNCT
dti-2469	145	9	n	n	CCONJ
dti-2469	145	10	-	-	PUNCT
dti-2469	145	11	acetyl	acetyl	NOUN
dti-2469	145	12	glucosaminyltransferase	glucosaminyltransferase	NOUN
dti-2469	145	13	(	(	PUNCT
dti-2469	145	14	murg	murg	NOUN
dti-2469	145	15	transferase	transferase	NOUN
dti-2469	145	16	)	)	PUNCT
dti-2469	145	17	0.893	0.893	NUM
dti-2469	145	18	0.452	0.452	NUM
dti-2469	145	19	4.63	4.63	NUM
dti-2469	145	20	1.88	1.88	NUM
dti-2469	145	21	0.832	0.832	NUM
dti-2469	145	22	7	7	NUM
dti-2469	145	23	.	.	PUNCT
dti-2469	146	1	org50_gene2566	org50_gene2566	PROPN
dti-2469	146	2	d	d	ADJ
dti-2469	146	3	-	-	PUNCT
dti-2469	146	4	alanyl	alanyl	VERB
dti-2469	146	5	-	-	PUNCT
dti-2469	146	6	d	d	NOUN
dti-2469	146	7	-	-	PUNCT
dti-2469	146	8	alanine	alanine	NOUN
dti-2469	146	9	carboxypeptidase	carboxypeptidase	NOUN
dti-2469	146	10	(	(	PUNCT
dti-2469	146	11	dd	dd	NOUN
dti-2469	146	12	-	-	PUNCT
dti-2469	146	13	cpase	cpase	NOUN
dti-2469	146	14	)	)	PUNCT
dti-2469	146	15	0.528	0.528	NUM
dti-2469	146	16	0.257	0.257	NUM
dti-2469	146	17	3.00	3.00	NUM
dti-2469	146	18	2.08	2.08	NUM
dti-2469	146	19	0.452	0.452	NUM
dti-2469	146	20	8	8	NUM
dti-2469	146	21	.	.	PUNCT
dti-2469	147	1	org95_gene1329	org95_gene1329	PROPN
dti-2469	147	2	c	c	PROPN
dti-2469	147	3	-	-	PUNCT
dti-2469	147	4	di	di	NOUN
dti-2469	147	5	-	-	PUNCT
dti-2469	147	6	gmp	gmp	NOUN
dti-2469	147	7	phosphodiesterase	phosphodiesterase	NOUN
dti-2469	147	8	(	(	PUNCT
dti-2469	147	9	pdca	pdca	PROPN
dti-2469	147	10	)	)	PUNCT
dti-2469	147	11	0.731	0.731	NUM
dti-2469	147	12	0.458	0.458	NUM
dti-2469	147	13	4.11	4.11	NUM
dti-2469	147	14	3.37	3.37	NUM
dti-2469	147	15	0.673	0.673	NUM
dti-2469	147	16	results	result	NOUN
dti-2469	147	17	are	be	AUX
dti-2469	147	18	shown	show	VERB
dti-2469	147	19	in	in	ADP
dti-2469	147	20	table	table	NOUN
dti-2469	147	21	i.	i.	NOUN
dti-2469	147	22	out	out	ADP
dti-2469	147	23	of	of	ADP
dti-2469	147	24	the	the	DET
dti-2469	147	25	eight	eight	NUM
dti-2469	147	26	drug	drug	NOUN
dti-2469	147	27	targets	target	NOUN
dti-2469	147	28	,	,	PUNCT
dti-2469	147	29	three	three	NUM
dti-2469	147	30	targets	target	NOUN
dti-2469	147	31	,	,	PUNCT
dti-2469	147	32	namely	namely	ADV
dti-2469	147	33	,	,	PUNCT
dti-2469	147	34	aminodeoxychorismate	aminodeoxychorismate	ADJ
dti-2469	147	35	synthase	synthase	NOUN
dti-2469	147	36	(	(	PUNCT
dti-2469	147	37	pabb	pabb	NOUN
dti-2469	147	38	)	)	PUNCT
dti-2469	147	39	,	,	PUNCT
dti-2469	147	40	d	d	X
dti-2469	147	41	-	-	PUNCT
dti-2469	147	42	alanyl	alanyl	VERB
dti-2469	147	43	-	-	PUNCT
dti-2469	147	44	d	d	NOUN
dti-2469	147	45	-	-	PUNCT
dti-2469	147	46	alanine	alanine	NOUN
dti-2469	147	47	carboxypeptidase	carboxypeptidase	NOUN
dti-2469	147	48	(	(	PUNCT
dti-2469	147	49	dd	dd	NOUN
dti-2469	147	50	-	-	PUNCT
dti-2469	147	51	cpase	cpase	NOUN
dti-2469	147	52	)	)	PUNCT
dti-2469	147	53	and	and	CCONJ
dti-2469	147	54	undecaprenyl	undecaprenyl	NOUN
dti-2469	147	55	diphospho	diphospho	NOUN
dti-2469	147	56	-	-	PUNCT
dti-2469	147	57	muramoyl	muramoyl	ADJ
dti-2469	147	58	pentapeptide	pentapeptide	NOUN
dti-2469	147	59	beta	beta	NOUN
dti-2469	147	60	-	-	PUNCT
dti-2469	147	61	n	n	NOUN
dti-2469	147	62	acetylglucosaminyl	acetylglucosaminyl	NOUN
dti-2469	147	63	transferase	transferase	NOUN
dti-2469	147	64	(	(	PUNCT
dti-2469	147	65	murg	murg	NOUN
dti-2469	147	66	transferase	transferase	NOUN
dti-2469	147	67	)	)	PUNCT
dti-2469	147	68	were	be	AUX
dti-2469	147	69	identified	identify	VERB
dti-2469	147	70	which	which	PRON
dti-2469	147	71	have	have	AUX
dti-2469	147	72	been	be	AUX
dti-2469	147	73	previously	previously	ADV
dti-2469	147	74	reported	report	VERB
dti-2469	147	75	(	(	PUNCT
dti-2469	147	76	35	35	NUM
dti-2469	147	77	)	)	PUNCT
dti-2469	147	78	.	.	PUNCT
dti-2469	148	1	pabb	pabb	NOUN
dti-2469	148	2	is	be	AUX
dti-2469	148	3	involved	involve	VERB
dti-2469	148	4	in	in	ADP
dti-2469	148	5	folate	folate	NOUN
dti-2469	148	6	synthesis	synthesis	NOUN
dti-2469	148	7	;	;	PUNCT
dti-2469	148	8	its	its	PRON
dti-2469	148	9	inhibition	inhibition	NOUN
dti-2469	148	10	affects	affect	VERB
dti-2469	148	11	dna	dna	NOUN
dti-2469	148	12	and	and	CCONJ
dti-2469	148	13	protein	protein	NOUN
dti-2469	148	14	synthesis	synthesis	NOUN
dti-2469	148	15	adversely	adversely	ADV
dti-2469	148	16	.	.	PUNCT
dti-2469	149	1	it	it	PRON
dti-2469	149	2	is	be	AUX
dti-2469	149	3	reported	report	VERB
dti-2469	149	4	that	that	SCONJ
dti-2469	149	5	it	it	PRON
dti-2469	149	6	is	be	AUX
dti-2469	149	7	targeted	target	VERB
dti-2469	149	8	by	by	ADP
dti-2469	149	9	the	the	DET
dti-2469	149	10	antibiotics	antibiotic	NOUN
dti-2469	149	11	6	6	NUM
dti-2469	149	12	-	-	PUNCT
dti-2469	149	13	fluoroshikimic	fluoroshikimic	ADJ
dti-2469	149	14	acid	acid	NOUN
dti-2469	149	15	and	and	CCONJ
dti-2469	149	16	atropabyssomycin	atropabyssomycin	NOUN
dti-2469	149	17	c	c	NOUN
dti-2469	149	18	(	(	PUNCT
dti-2469	149	19	35	35	NUM
dti-2469	149	20	)	)	PUNCT
dti-2469	149	21	.	.	PUNCT
dti-2469	150	1	bifunctional	bifunctional	ADJ
dti-2469	150	2	diguanylate	diguanylate	NOUN
dti-2469	150	3	cyclase	cyclase	NOUN
dti-2469	150	4	/	/	SYM
dti-2469	150	5	phosphodiesterase	phosphodiesterase	NOUN
dti-2469	150	6	(	(	PUNCT
dti-2469	150	7	cyclic	cyclic	NOUN
dti-2469	150	8	-	-	PUNCT
dti-2469	150	9	digmp	digmp	NOUN
dti-2469	150	10	)	)	PUNCT
dti-2469	150	11	is	be	AUX
dti-2469	150	12	a	a	DET
dti-2469	150	13	messenger	messenger	NOUN
dti-2469	150	14	protein	protein	NOUN
dti-2469	150	15	that	that	PRON
dti-2469	150	16	regulates	regulate	VERB
dti-2469	150	17	motility	motility	NOUN
dti-2469	150	18	,	,	PUNCT
dti-2469	150	19	virulence	virulence	NOUN
dti-2469	150	20	and	and	CCONJ
dti-2469	150	21	biofilm	biofilm	NOUN
dti-2469	150	22	formation	formation	NOUN
dti-2469	150	23	attributed	attribute	VERB
dti-2469	150	24	to	to	ADP
dti-2469	150	25	pathogenicity	pathogenicity	NOUN
dti-2469	150	26	(	(	PUNCT
dti-2469	150	27	36,37	36,37	NUM
dti-2469	150	28	)	)	PUNCT
dti-2469	150	29	.	.	PUNCT
dti-2469	151	1	inhibition	inhibition	NOUN
dti-2469	151	2	of	of	ADP
dti-2469	151	3	cyclic	cyclic	NOUN
dti-2469	151	4	-	-	PUNCT
dti-2469	151	5	digmp	digmp	NOUN
dti-2469	151	6	affects	affect	VERB
dti-2469	151	7	many	many	ADJ
dti-2469	151	8	processes	process	NOUN
dti-2469	151	9	of	of	ADP
dti-2469	151	10	the	the	DET
dti-2469	151	11	pathogen	pathogen	NOUN
dti-2469	151	12	that	that	PRON
dti-2469	151	13	result	result	VERB
dti-2469	151	14	in	in	ADP
dti-2469	151	15	the	the	DET
dti-2469	151	16	death	death	NOUN
dti-2469	151	17	of	of	ADP
dti-2469	151	18	the	the	DET
dti-2469	151	19	pathogen	pathogen	NOUN
dti-2469	151	20	.	.	PUNCT
dti-2469	152	1	another	another	DET
dti-2469	152	2	identified	identify	VERB
dti-2469	152	3	target	target	NOUN
dti-2469	152	4	is	be	AUX
dti-2469	152	5	sporulation	sporulation	NOUN
dti-2469	152	6	transcription	transcription	NOUN
dti-2469	152	7	factor	factor	NOUN
dti-2469	152	8	spo0a	spo0a	PROPN
dti-2469	152	9	,	,	PUNCT
dti-2469	152	10	which	which	PRON
dti-2469	152	11	is	be	AUX
dti-2469	152	12	a	a	DET
dti-2469	152	13	key	key	ADJ
dti-2469	152	14	factor	factor	NOUN
dti-2469	152	15	for	for	ADP
dti-2469	152	16	entry	entry	NOUN
dti-2469	152	17	into	into	ADP
dti-2469	152	18	sporulation	sporulation	NOUN
dti-2469	152	19	in	in	ADP
dti-2469	152	20	stress	stress	NOUN
dti-2469	152	21	conditions	condition	NOUN
dti-2469	152	22	and	and	CCONJ
dti-2469	152	23	biofilm	biofilm	NOUN
dti-2469	152	24	formation	formation	NOUN
dti-2469	152	25	(	(	PUNCT
dti-2469	152	26	38	38	NUM
dti-2469	152	27	)	)	PUNCT
dti-2469	152	28	.	.	PUNCT
dti-2469	153	1	histidinol	histidinol	ADJ
dti-2469	153	2	-	-	PUNCT
dti-2469	153	3	phosphate	phosphate	NOUN
dti-2469	153	4	transaminase	transaminase	NOUN
dti-2469	153	5	(	(	PUNCT
dti-2469	153	6	hisc	hisc	NOUN
dti-2469	153	7	)	)	PUNCT
dti-2469	153	8	is	be	AUX
dti-2469	153	9	a	a	DET
dti-2469	153	10	transferase	transferase	NOUN
dti-2469	153	11	that	that	PRON
dti-2469	153	12	is	be	AUX
dti-2469	153	13	mainly	mainly	ADV
dti-2469	153	14	involved	involve	VERB
dti-2469	153	15	in	in	ADP
dti-2469	153	16	transferring	transfer	VERB
dti-2469	153	17	nitrogenous	nitrogenous	ADJ
dti-2469	153	18	group	group	NOUN
dti-2469	153	19	.	.	PUNCT
dti-2469	154	1	it	it	PRON
dti-2469	154	2	is	be	AUX
dti-2469	154	3	involved	involve	VERB
dti-2469	154	4	in	in	ADP
dti-2469	154	5	synthesis	synthesis	NOUN
dti-2469	154	6	and	and	CCONJ
dti-2469	154	7	metabolism	metabolism	NOUN
dti-2469	154	8	of	of	ADP
dti-2469	154	9	many	many	ADJ
dti-2469	154	10	amino	amino	ADJ
dti-2469	154	11	acids	acid	NOUN
dti-2469	154	12	(	(	PUNCT
dti-2469	154	13	39	39	NUM
dti-2469	154	14	)	)	PUNCT
dti-2469	154	15	.	.	PUNCT
dti-2469	155	1	3	3	NUM
dti-2469	155	2	-	-	PUNCT
dti-2469	155	3	deoxy-7	deoxy-7	NUM
dti-2469	155	4	phosphoheptulonate	phosphoheptulonate	ADJ
dti-2469	155	5	synthase	synthase	NOUN
dti-2469	155	6	(	(	PUNCT
dti-2469	155	7	dahp	dahp	NOUN
dti-2469	155	8	synthase	synthase	NOUN
dti-2469	155	9	)	)	PUNCT
dti-2469	155	10	is	be	AUX
dti-2469	155	11	involved	involve	VERB
dti-2469	155	12	in	in	ADP
dti-2469	155	13	the	the	DET
dti-2469	155	14	shikimate	shikimate	NOUN
dti-2469	155	15	pathway	pathway	NOUN
dti-2469	155	16	and	and	CCONJ
dti-2469	155	17	is	be	AUX
dti-2469	155	18	also	also	ADV
dti-2469	155	19	responsible	responsible	ADJ
dti-2469	155	20	for	for	ADP
dti-2469	155	21	the	the	DET
dti-2469	155	22	synthesis	synthesis	NOUN
dti-2469	155	23	of	of	ADP
dti-2469	155	24	aromatic	aromatic	ADJ
dti-2469	155	25	amino	amino	NOUN
dti-2469	155	26	acids	acid	NOUN
dti-2469	155	27	,	,	PUNCT
dti-2469	155	28	such	such	ADJ
dti-2469	155	29	as	as	ADP
dti-2469	155	30	tyrosine	tyrosine	NOUN
dti-2469	155	31	,	,	PUNCT
dti-2469	155	32	phenylalanine	phenylalanine	NOUN
dti-2469	155	33	and	and	CCONJ
dti-2469	155	34	tryptophan	tryptophan	NOUN
dti-2469	155	35	which	which	PRON
dti-2469	155	36	are	be	AUX
dti-2469	155	37	essential	essential	ADJ
dti-2469	155	38	for	for	ADP
dti-2469	155	39	bacterial	bacterial	ADJ
dti-2469	155	40	metabolism	metabolism	NOUN
dti-2469	155	41	(	(	PUNCT
dti-2469	155	42	40	40	NUM
dti-2469	155	43	)	)	PUNCT
dti-2469	155	44	.	.	PUNCT
dti-2469	156	1	another	another	DET
dti-2469	156	2	identified	identify	VERB
dti-2469	156	3	drug	drug	NOUN
dti-2469	156	4	target	target	NOUN
dti-2469	156	5	,	,	PUNCT
dti-2469	156	6	murg	murg	NOUN
dti-2469	156	7	transferase	transferase	NOUN
dti-2469	156	8	,	,	PUNCT
dti-2469	156	9	is	be	AUX
dti-2469	156	10	involved	involve	VERB
dti-2469	156	11	in	in	ADP
dti-2469	156	12	the	the	DET
dti-2469	156	13	peptidoglycan	peptidoglycan	ADJ
dti-2469	156	14	biosynthesis	biosynthesis	NOUN
dti-2469	156	15	and	and	CCONJ
dti-2469	156	16	is	be	AUX
dti-2469	156	17	reported	report	VERB
dti-2469	156	18	to	to	PART
dti-2469	156	19	be	be	AUX
dti-2469	156	20	the	the	DET
dti-2469	156	21	drug	drug	NOUN
dti-2469	156	22	target	target	NOUN
dti-2469	156	23	for	for	ADP
dti-2469	156	24	many	many	ADJ
dti-2469	156	25	pathogens	pathogen	NOUN
dti-2469	156	26	such	such	ADJ
dti-2469	156	27	as	as	ADP
dti-2469	156	28	neisseria	neisseria	PROPN
dti-2469	156	29	meningitidis	meningitidis	PROPN
dti-2469	156	30	(	(	PUNCT
dti-2469	156	31	41	41	NUM
dti-2469	156	32	)	)	PUNCT
dti-2469	156	33	,	,	PUNCT
dti-2469	157	1	acinetobacter	acinetobacter	ADV
dti-2469	157	2	baumannii	baumannii	ADJ
dti-2469	157	3	(	(	PUNCT
dti-2469	157	4	42	42	NUM
dti-2469	157	5	)	)	PUNCT
dti-2469	157	6	and	and	CCONJ
dti-2469	157	7	mycobacterium	mycobacterium	NOUN
dti-2469	157	8	tuberculosis	tuberculosis	NOUN
dti-2469	157	9	(	(	PUNCT
dti-2469	157	10	43	43	NUM
dti-2469	157	11	)	)	PUNCT
dti-2469	157	12	.	.	PUNCT
dti-2469	158	1	another	another	DET
dti-2469	158	2	identified	identify	VERB
dti-2469	158	3	potent	potent	ADJ
dti-2469	158	4	target	target	NOUN
dti-2469	158	5	,	,	PUNCT
dti-2469	158	6	dd	dd	NOUN
dti-2469	158	7	-	-	PUNCT
dti-2469	158	8	cpase	cpase	NOUN
dti-2469	158	9	is	be	AUX
dti-2469	158	10	a	a	DET
dti-2469	158	11	reported	report	VERB
dti-2469	158	12	drug	drug	NOUN
dti-2469	158	13	target	target	NOUN
dti-2469	158	14	and	and	CCONJ
dti-2469	158	15	is	be	AUX
dti-2469	158	16	involved	involve	VERB
dti-2469	158	17	in	in	ADP
dti-2469	158	18	peptidoglycan	peptidoglycan	ADJ
dti-2469	158	19	biosynthesis	biosynthesis	NOUN
dti-2469	158	20	and	and	CCONJ
dti-2469	158	21	remodelling	remodelling	NOUN
dti-2469	158	22	and	and	CCONJ
dti-2469	158	23	is	be	AUX
dti-2469	158	24	inhibited	inhibit	VERB
dti-2469	158	25	by	by	ADP
dti-2469	158	26	β	β	NOUN
dti-2469	158	27	-	-	NOUN
dti-2469	158	28	lactam	lactam	NOUN
dti-2469	158	29	antibiotics	antibiotic	NOUN
dti-2469	158	30	(	(	PUNCT
dti-2469	158	31	44	44	NUM
dti-2469	158	32	)	)	PUNCT
dti-2469	158	33	.	.	PUNCT
dti-2469	159	1	c	c	X
dti-2469	159	2	-	-	PUNCT
dti-2469	159	3	di	di	NOUN
dti-2469	159	4	-	-	PUNCT
dti-2469	159	5	gmp	gmp	NOUN
dti-2469	159	6	phosphodiesterase	phosphodiesterase	NOUN
dti-2469	159	7	(	(	PUNCT
dti-2469	159	8	pdca	pdca	PROPN
dti-2469	159	9	)	)	PUNCT
dti-2469	159	10	is	be	AUX
dti-2469	159	11	a	a	DET
dti-2469	159	12	potent	potent	ADJ
dti-2469	159	13	drug	drug	NOUN
dti-2469	159	14	target	target	NOUN
dti-2469	159	15	that	that	PRON
dti-2469	159	16	regulates	regulate	VERB
dti-2469	159	17	bacterial	bacterial	ADJ
dti-2469	159	18	pathogenesis	pathogenesis	NOUN
dti-2469	159	19	as	as	ADV
dti-2469	159	20	well	well	ADV
dti-2469	159	21	as	as	ADP
dti-2469	159	22	is	be	AUX
dti-2469	159	23	involved	involve	VERB
dti-2469	159	24	in	in	ADP
dti-2469	159	25	surface	surface	NOUN
dti-2469	159	26	adherence	adherence	NOUN
dti-2469	159	27	and	and	CCONJ
dti-2469	159	28	biofilm	biofilm	NOUN
dti-2469	159	29	development	development	NOUN
dti-2469	159	30	(	(	PUNCT
dti-2469	159	31	45	45	NUM
dti-2469	159	32	)	)	PUNCT
dti-2469	159	33	.	.	PUNCT
dti-2469	160	1	conclusion	conclusion	NOUN
dti-2469	160	2	cdi	cdi	PROPN
dti-2469	160	3	is	be	AUX
dti-2469	160	4	a	a	DET
dti-2469	160	5	challenging	challenging	ADJ
dti-2469	160	6	situation	situation	NOUN
dti-2469	160	7	worldwide	worldwide	ADV
dti-2469	160	8	.	.	PUNCT
dti-2469	161	1	the	the	DET
dti-2469	161	2	unavailability	unavailability	NOUN
dti-2469	161	3	of	of	ADP
dti-2469	161	4	specific	specific	ADJ
dti-2469	161	5	antibiotic	antibiotic	NOUN
dti-2469	161	6	and	and	CCONJ
dti-2469	161	7	emergence	emergence	NOUN
dti-2469	161	8	of	of	ADP
dti-2469	161	9	antibiotic	antibiotic	ADJ
dti-2469	161	10	resistance	resistance	NOUN
dti-2469	161	11	against	against	ADP
dti-2469	161	12	c.	c.	NOUN
dti-2469	161	13	difficile	difficile	PROPN
dti-2469	161	14	is	be	AUX
dti-2469	161	15	a	a	DET
dti-2469	161	16	matter	matter	NOUN
dti-2469	161	17	of	of	ADP
dti-2469	161	18	concern	concern	NOUN
dti-2469	161	19	.	.	PUNCT
dti-2469	162	1	diversity	diversity	NOUN
dti-2469	162	2	in	in	ADP
dti-2469	162	3	c.	c.	PROPN
dti-2469	162	4	difficile	difficile	PROPN
dti-2469	162	5	genome	genome	NOUN
dti-2469	162	6	drives	drive	VERB
dti-2469	162	7	the	the	DET
dti-2469	162	8	genomic	genomic	ADJ
dti-2469	162	9	comparison	comparison	NOUN
dti-2469	162	10	of	of	ADP
dti-2469	162	11	the	the	DET
dti-2469	162	12	pathogen	pathogen	NOUN
dti-2469	162	13	.	.	PUNCT
dti-2469	163	1	pangenome	pangenome	NOUN
dti-2469	163	2	analysis	analysis	NOUN
dti-2469	163	3	reveals	reveal	VERB
dti-2469	163	4	the	the	DET
dti-2469	163	5	open	open	ADJ
dti-2469	163	6	pangenome	pangenome	NOUN
dti-2469	163	7	of	of	ADP
dti-2469	163	8	c.	c.	PROPN
dti-2469	163	9	difficile	difficile	NOUN
dti-2469	163	10	that	that	PRON
dti-2469	163	11	may	may	AUX
dti-2469	163	12	be	be	AUX
dti-2469	163	13	soon	soon	ADV
dti-2469	163	14	closed	close	VERB
dti-2469	163	15	.	.	PUNCT
dti-2469	164	1	the	the	DET
dti-2469	164	2	diversity	diversity	NOUN
dti-2469	164	3	is	be	AUX
dti-2469	164	4	due	due	ADJ
dti-2469	164	5	to	to	ADP
dti-2469	164	6	its	its	PRON
dti-2469	164	7	adaptability	adaptability	NOUN
dti-2469	164	8	in	in	ADP
dti-2469	164	9	different	different	ADJ
dti-2469	164	10	niches	niche	NOUN
dti-2469	164	11	and	and	CCONJ
dti-2469	164	12	different	different	ADJ
dti-2469	164	13	hosts	host	NOUN
dti-2469	164	14	.	.	PUNCT
dti-2469	165	1	due	due	ADP
dti-2469	165	2	to	to	ADP
dti-2469	165	3	such	such	ADJ
dti-2469	165	4	genomic	genomic	ADJ
dti-2469	165	5	diversity	diversity	NOUN
dti-2469	165	6	,	,	PUNCT
dti-2469	165	7	a	a	DET
dti-2469	165	8	drug	drug	NOUN
dti-2469	165	9	target	target	NOUN
dti-2469	165	10	can	can	AUX
dti-2469	165	11	be	be	AUX
dti-2469	165	12	designed	design	VERB
dti-2469	165	13	only	only	ADV
dti-2469	165	14	from	from	ADP
dti-2469	165	15	its	its	PRON
dti-2469	165	16	core	core	NOUN
dti-2469	165	17	gene	gene	NOUN
dti-2469	165	18	,	,	PUNCT
dti-2469	165	19	whose	whose	DET
dti-2469	165	20	inhibition	inhibition	NOUN
dti-2469	165	21	affects	affect	VERB
dti-2469	165	22	all	all	DET
dti-2469	165	23	strains	strain	NOUN
dti-2469	165	24	of	of	ADP
dti-2469	165	25	c.	c.	NOUN
dti-2469	165	26	difficile	difficile	PROPN
dti-2469	165	27	.	.	PUNCT
dti-2469	166	1	from	from	ADP
dti-2469	166	2	sequence	sequence	NOUN
dti-2469	166	3	and	and	CCONJ
dti-2469	166	4	interactome	interactome	NOUN
dti-2469	166	5	analysis	analysis	NOUN
dti-2469	166	6	of	of	ADP
dti-2469	166	7	core	core	NOUN
dti-2469	166	8	genes	gene	NOUN
dti-2469	166	9	,	,	PUNCT
dti-2469	166	10	eight	eight	NUM
dti-2469	166	11	potent	potent	ADJ
dti-2469	166	12	drug	drug	NOUN
dti-2469	166	13	targets	target	NOUN
dti-2469	166	14	are	be	AUX
dti-2469	166	15	reported	report	VERB
dti-2469	166	16	.	.	PUNCT
dti-2469	167	1	out	out	ADP
dti-2469	167	2	of	of	ADP
dti-2469	167	3	these	these	PRON
dti-2469	167	4	,	,	PUNCT
dti-2469	167	5	three	three	NUM
dti-2469	167	6	of	of	ADP
dti-2469	167	7	the	the	DET
dti-2469	167	8	targets	target	NOUN
dti-2469	167	9	–	–	PUNCT
dti-2469	167	10	pabb	pabb	NOUN
dti-2469	167	11	,	,	PUNCT
dti-2469	167	12	dd	dd	NOUN
dti-2469	167	13	-	-	ADJ
dti-2469	167	14	cpase	cpase	ADJ
dti-2469	167	15	and	and	CCONJ
dti-2469	167	16	murg	murg	PROPN
dti-2469	167	17	transferase	transferase	NOUN
dti-2469	167	18	–	–	PUNCT
dti-2469	167	19	are	be	AUX
dti-2469	167	20	also	also	ADV
dti-2469	167	21	reported	report	VERB
dti-2469	167	22	as	as	ADP
dti-2469	167	23	drug	drug	NOUN
dti-2469	167	24	target	target	NOUN
dti-2469	167	25	for	for	ADP
dti-2469	167	26	other	other	ADJ
dti-2469	167	27	pathogens	pathogen	NOUN
dti-2469	167	28	,	,	PUNCT
dti-2469	167	29	whereas	whereas	SCONJ
dti-2469	167	30	bifunctional	bifunctional	ADJ
dti-2469	167	31	cyclic	cyclic	NOUN
dti-2469	167	32	-	-	PUNCT
dti-2469	167	33	digmp	digmp	NOUN
dti-2469	167	34	,	,	PUNCT
dti-2469	167	35	spo0a	spo0a	PROPN
dti-2469	167	36	,	,	PUNCT
dti-2469	167	37	hisc	hisc	NOUN
dti-2469	167	38	,	,	PUNCT
dti-2469	167	39	dahp	dahp	NOUN
dti-2469	167	40	synthase	synthase	NOUN
dti-2469	167	41	and	and	CCONJ
dti-2469	167	42	pdca	pdca	PROPN
dti-2469	167	43	are	be	AUX
dti-2469	167	44	newly	newly	ADV
dti-2469	167	45	reported	report	VERB
dti-2469	167	46	targets	target	NOUN
dti-2469	167	47	.	.	PUNCT
dti-2469	168	1	this	this	PRON
dti-2469	168	2	indicates	indicate	VERB
dti-2469	168	3	that	that	SCONJ
dti-2469	168	4	the	the	DET
dti-2469	168	5	method	method	NOUN
dti-2469	168	6	originated	originate	VERB
dti-2469	168	7	in	in	ADP
dti-2469	168	8	the	the	DET
dti-2469	168	9	present	present	ADJ
dti-2469	168	10	study	study	NOUN
dti-2469	168	11	has	have	VERB
dti-2469	168	12	a	a	DET
dti-2469	168	13	high	high	ADJ
dti-2469	168	14	rate	rate	NOUN
dti-2469	168	15	of	of	ADP
dti-2469	168	16	success	success	NOUN
dti-2469	168	17	and	and	CCONJ
dti-2469	168	18	saves	save	VERB
dti-2469	168	19	considerable	considerable	ADJ
dti-2469	168	20	time	time	NOUN
dti-2469	168	21	and	and	CCONJ
dti-2469	168	22	money	money	NOUN
dti-2469	168	23	.	.	PUNCT
dti-2469	169	1	the	the	DET
dti-2469	169	2	same	same	ADJ
dti-2469	169	3	method	method	NOUN
dti-2469	169	4	can	can	AUX
dti-2469	169	5	be	be	AUX
dti-2469	169	6	used	use	VERB
dti-2469	169	7	for	for	ADP
dti-2469	169	8	other	other	ADJ
dti-2469	169	9	pathogens	pathogen	NOUN
dti-2469	169	10	also	also	ADV
dti-2469	169	11	.	.	PUNCT
dti-2469	170	1	limitations	limitation	NOUN
dti-2469	170	2	of	of	ADP
dti-2469	170	3	the	the	DET
dti-2469	170	4	study	study	NOUN
dti-2469	170	5	this	this	DET
dti-2469	170	6	computational	computational	ADJ
dti-2469	170	7	method	method	NOUN
dti-2469	170	8	uses	use	VERB
dti-2469	170	9	multiple	multiple	ADJ
dti-2469	170	10	genomes	genome	NOUN
dti-2469	170	11	with	with	ADP
dti-2469	170	12	complete	complete	ADJ
dti-2469	170	13	genome	genome	NOUN
dti-2469	170	14	assembly	assembly	NOUN
dti-2469	170	15	,	,	PUNCT
dti-2469	170	16	therefore	therefore	ADV
dti-2469	170	17	this	this	DET
dti-2469	170	18	method	method	NOUN
dti-2469	170	19	can	can	AUX
dti-2469	170	20	not	not	PART
dti-2469	170	21	be	be	AUX
dti-2469	170	22	employed	employ	VERB
dti-2469	170	23	for	for	ADP
dti-2469	170	24	pathogens	pathogen	NOUN
dti-2469	170	25	whose	whose	DET
dti-2469	170	26	majority	majority	NOUN
dti-2469	170	27	of	of	ADP
dti-2469	170	28	the	the	DET
dti-2469	170	29	strains	strain	NOUN
dti-2469	170	30	have	have	AUX
dti-2469	170	31	not	not	PART
dti-2469	170	32	been	be	AUX
dti-2469	170	33	sequenced	sequence	VERB
dti-2469	170	34	.	.	PUNCT
dti-2469	171	1	pangenome	pangenome	NOUN
dti-2469	171	2	analysis	analysis	NOUN
dti-2469	171	3	can	can	AUX
dti-2469	171	4	only	only	ADV
dti-2469	171	5	be	be	AUX
dti-2469	171	6	performed	perform	VERB
dti-2469	171	7	if	if	SCONJ
dti-2469	171	8	multiple	multiple	ADJ
dti-2469	171	9	sequenced	sequence	VERB
dti-2469	171	10	strains	strain	NOUN
dti-2469	171	11	are	be	AUX
dti-2469	171	12	available	available	ADJ
dti-2469	171	13	for	for	ADP
dti-2469	171	14	the	the	DET
dti-2469	171	15	organism	organism	NOUN
dti-2469	171	16	.	.	PUNCT
dti-2469	172	1	pangenomics	pangenomic	NOUN
dti-2469	172	2	can	can	AUX
dti-2469	172	3	easily	easily	ADV
dti-2469	172	4	be	be	AUX
dti-2469	172	5	done	do	VERB
dti-2469	172	6	only	only	ADV
dti-2469	172	7	when	when	SCONJ
dti-2469	172	8	proper	proper	ADJ
dti-2469	172	9	software	software	NOUN
dti-2469	172	10	or	or	CCONJ
dti-2469	172	11	tool	tool	NOUN
dti-2469	172	12	is	be	AUX
dti-2469	172	13	available	available	ADJ
dti-2469	172	14	;	;	PUNCT
dti-2469	172	15	it	it	PRON
dti-2469	172	16	is	be	AUX
dti-2469	172	17	very	very	ADV
dti-2469	172	18	complex	complex	ADJ
dti-2469	172	19	to	to	PART
dti-2469	172	20	handle	handle	VERB
dti-2469	172	21	the	the	DET
dti-2469	172	22	genome	genome	NOUN
dti-2469	172	23	manually	manually	ADV
dti-2469	172	24	.	.	PUNCT
dti-2469	173	1	another	another	DET
dti-2469	173	2	limitation	limitation	NOUN
dti-2469	173	3	with	with	ADP
dti-2469	173	4	this	this	DET
dti-2469	173	5	study	study	NOUN
dti-2469	173	6	is	be	AUX
dti-2469	173	7	the	the	DET
dti-2469	173	8	use	use	NOUN
dti-2469	173	9	of	of	ADP
dti-2469	173	10	in	in	ADP
dti-2469	173	11	silico	silico	NOUN
dti-2469	173	12	method	method	NOUN
dti-2469	173	13	for	for	ADP
dti-2469	173	14	drug	drug	NOUN
dti-2469	173	15	target	target	NOUN
dti-2469	173	16	identification	identification	NOUN
dti-2469	173	17	that	that	PRON
dti-2469	173	18	saves	save	VERB
dti-2469	173	19	considerable	considerable	ADJ
dti-2469	173	20	time	time	NOUN
dti-2469	173	21	and	and	CCONJ
dti-2469	173	22	money	money	NOUN
dti-2469	173	23	,	,	PUNCT
dti-2469	173	24	but	but	CCONJ
dti-2469	173	25	its	its	PRON
dti-2469	173	26	accuracy	accuracy	NOUN
dti-2469	173	27	is	be	AUX
dti-2469	173	28	still	still	ADV
dti-2469	173	29	questionable	questionable	ADJ
dti-2469	173	30	.	.	PUNCT
dti-2469	174	1	we	we	PRON
dti-2469	174	2	have	have	AUX
dti-2469	174	3	used	use	VERB
dti-2469	174	4	the	the	DET
dti-2469	174	5	core	core	NOUN
dti-2469	174	6	genes	gene	NOUN
dti-2469	174	7	which	which	PRON
dti-2469	174	8	are	be	AUX
dti-2469	174	9	conserved	conserve	VERB
dti-2469	174	10	and	and	CCONJ
dti-2469	174	11	involved	involve	VERB
dti-2469	174	12	in	in	ADP
dti-2469	174	13	essential	essential	ADJ
dti-2469	174	14	processes	process	NOUN
dti-2469	174	15	for	for	ADP
dti-2469	174	16	drug	drug	NOUN
dti-2469	174	17	target	target	NOUN
dti-2469	174	18	golchha	golchha	PROPN
dti-2469	174	19	et	et	PROPN
dti-2469	174	20	al	al	PROPN
dti-2469	174	21	drug	drug	PROPN
dti-2469	174	22	target	target	NOUN
dti-2469	174	23	insights	insight	NOUN
dti-2469	174	24	2022	2022	NUM
dti-2469	174	25	;	;	PUNCT
dti-2469	174	26	16	16	NUM
dti-2469	174	27	:	:	SYM
dti-2469	174	28	23	23	NUM
dti-2469	175	1	©	©	ADP
dti-2469	175	2	2022	2022	NUM
dti-2469	176	1	the	the	DET
dti-2469	176	2	authors	author	NOUN
dti-2469	176	3	.	.	PUNCT
dti-2469	176	4	published	publish	VERB
dti-2469	176	5	by	by	ADP
dti-2469	176	6	aboutscience	aboutscience	NOUN
dti-2469	176	7	www.aboutscience.eu	www.aboutscience.eu	NOUN
dti-2469	176	8	identification	identification	NOUN
dti-2469	176	9	,	,	PUNCT
dti-2469	176	10	but	but	CCONJ
dti-2469	176	11	the	the	DET
dti-2469	176	12	drug	drug	NOUN
dti-2469	176	13	targets	target	NOUN
dti-2469	176	14	from	from	ADP
dti-2469	176	15	novel	novel	ADJ
dti-2469	176	16	genes	gene	NOUN
dti-2469	176	17	which	which	PRON
dti-2469	176	18	the	the	DET
dti-2469	176	19	bacteria	bacteria	NOUN
dti-2469	176	20	inherits	inherit	VERB
dti-2469	176	21	from	from	ADP
dti-2469	176	22	its	its	PRON
dti-2469	176	23	adaptation	adaptation	NOUN
dti-2469	176	24	in	in	ADP
dti-2469	176	25	new	new	ADJ
dti-2469	176	26	niches	niche	NOUN
dti-2469	176	27	can	can	AUX
dti-2469	176	28	not	not	PART
dti-2469	176	29	be	be	AUX
dti-2469	176	30	considered	consider	VERB
dti-2469	176	31	in	in	ADP
dti-2469	176	32	this	this	DET
dti-2469	176	33	type	type	NOUN
dti-2469	176	34	of	of	ADP
dti-2469	176	35	study	study	NOUN
dti-2469	176	36	.	.	PUNCT
dti-2469	177	1	acknowledgements	acknowledgement	NOUN
dti-2469	177	2	the	the	DET
dti-2469	177	3	authors	author	NOUN
dti-2469	177	4	acknowledge	acknowledge	VERB
dti-2469	177	5	the	the	DET
dti-2469	177	6	facilities	facility	NOUN
dti-2469	177	7	of	of	ADP
dti-2469	177	8	the	the	DET
dti-2469	177	9	department	department	NOUN
dti-2469	177	10	of	of	ADP
dti-2469	177	11	biotechnology	biotechnology	NOUN
dti-2469	177	12	,	,	PUNCT
dti-2469	177	13	ministry	ministry	PROPN
dti-2469	177	14	of	of	ADP
dti-2469	177	15	science	science	NOUN
dti-2469	177	16	and	and	CCONJ
dti-2469	177	17	technology	technology	NOUN
dti-2469	177	18	,	,	PUNCT
dti-2469	177	19	government	government	NOUN
dti-2469	177	20	of	of	ADP
dti-2469	177	21	india	india	PROPN
dti-2469	177	22	,	,	PUNCT
dti-2469	177	23	new	new	ADJ
dti-2469	177	24	delhi	delhi	PROPN
dti-2469	177	25	(	(	PUNCT
dti-2469	177	26	dbt	dbt	PROPN
dti-2469	177	27	)	)	PUNCT
dti-2469	177	28	,	,	PUNCT
dti-2469	177	29	under	under	ADP
dti-2469	177	30	the	the	DET
dti-2469	177	31	bioinformatics	bioinformatics	NOUN
dti-2469	177	32	sub	sub	NOUN
dti-2469	177	33	centre	centre	NOUN
dti-2469	177	34	as	as	ADV
dti-2469	177	35	well	well	ADV
dti-2469	177	36	as	as	ADP
dti-2469	177	37	m.sc	m.sc	PROPN
dti-2469	177	38	.	.	PUNCT
dti-2469	178	1	biotechnology	biotechnology	NOUN
dti-2469	178	2	programme	programme	NOUN
dti-2469	178	3	used	use	VERB
dti-2469	178	4	in	in	ADP
dti-2469	178	5	the	the	DET
dti-2469	178	6	present	present	ADJ
dti-2469	178	7	work	work	NOUN
dti-2469	178	8	.	.	PUNCT
dti-2469	179	1	disclosures	disclosure	VERB
dti-2469	179	2	conflict	conflict	NOUN
dti-2469	179	3	of	of	ADP
dti-2469	179	4	interest	interest	NOUN
dti-2469	179	5	:	:	PUNCT
dti-2469	179	6	the	the	DET
dti-2469	179	7	authors	author	NOUN
dti-2469	179	8	confirm	confirm	VERB
dti-2469	179	9	that	that	SCONJ
dti-2469	179	10	they	they	PRON
dti-2469	179	11	have	have	VERB
dti-2469	179	12	no	no	DET
dti-2469	179	13	conflict	conflict	NOUN
dti-2469	179	14	of	of	ADP
dti-2469	179	15	interest	interest	NOUN
dti-2469	179	16	.	.	PUNCT
dti-2469	180	1	financial	financial	ADJ
dti-2469	180	2	support	support	NOUN
dti-2469	180	3	:	:	PUNCT
dti-2469	180	4	this	this	DET
dti-2469	180	5	research	research	NOUN
dti-2469	180	6	received	receive	VERB
dti-2469	180	7	no	no	DET
dti-2469	180	8	specific	specific	ADJ
dti-2469	180	9	grant	grant	NOUN
dti-2469	180	10	from	from	ADP
dti-2469	180	11	any	any	DET
dti-2469	180	12	funding	funding	NOUN
dti-2469	180	13	agency	agency	NOUN
dti-2469	180	14	in	in	ADP
dti-2469	180	15	the	the	DET
dti-2469	180	16	public	public	ADJ
dti-2469	180	17	,	,	PUNCT
dti-2469	180	18	commercial	commercial	ADJ
dti-2469	180	19	or	or	CCONJ
dti-2469	180	20	not	not	PART
dti-2469	180	21	-	-	PUNCT
dti-2469	180	22	for	for	ADP
dti-2469	180	23	-	-	PUNCT
dti-2469	180	24	profit	profit	NOUN
dti-2469	180	25	sectors	sector	NOUN
dti-2469	180	26	.	.	PUNCT
dti-2469	181	1	references	reference	NOUN
dti-2469	181	2	1	1	NUM
dti-2469	181	3	.	.	PUNCT
dti-2469	182	1	zhu	zhu	PROPN
dti-2469	182	2	d	d	PROPN
dti-2469	182	3	,	,	PUNCT
dti-2469	182	4	sorg	sorg	PROPN
dti-2469	182	5	ja	ja	PROPN
dti-2469	182	6	,	,	PUNCT
dti-2469	182	7	sun	sun	PROPN
dti-2469	182	8	x.	x.	NOUN
dti-2469	182	9	clostridioides	clostridioide	VERB
dti-2469	182	10	difficile	difficile	ADJ
dti-2469	182	11	biology	biology	NOUN
dti-2469	182	12	:	:	PUNCT
dti-2469	182	13	sporulation	sporulation	NOUN
dti-2469	182	14	,	,	PUNCT
dti-2469	182	15	germination	germination	NOUN
dti-2469	182	16	,	,	PUNCT
dti-2469	182	17	and	and	CCONJ
dti-2469	182	18	corresponding	correspond	VERB
dti-2469	182	19	therapies	therapy	NOUN
dti-2469	182	20	for	for	ADP
dti-2469	182	21	c.	c.	NOUN
dti-2469	182	22	difficile	difficile	PROPN
dti-2469	182	23	infection	infection	NOUN
dti-2469	182	24	.	.	PUNCT
dti-2469	183	1	front	front	ADJ
dti-2469	183	2	cell	cell	NOUN
dti-2469	183	3	infect	infect	VERB
dti-2469	183	4	microbiol	microbiol	PROPN
dti-2469	183	5	.	.	PUNCT
dti-2469	184	1	2018;8:29	2018;8:29	NOUN
dti-2469	184	2	.	.	PUNCT
dti-2469	185	1	crossref	crossref	PROPN
dti-2469	185	2	pubmed	pubmed	PROPN
dti-2469	185	3	2	2	PROPN
dti-2469	185	4	.	.	PUNCT
dti-2469	185	5	leffler	leffler	PROPN
dti-2469	185	6	da	da	PROPN
dti-2469	185	7	,	,	PUNCT
dti-2469	185	8	lamont	lamont	PROPN
dti-2469	185	9	jt	jt	PROPN
dti-2469	185	10	.	.	PUNCT
dti-2469	185	11	clostridium	clostridium	PROPN
dti-2469	185	12	difficile	difficile	ADJ
dti-2469	185	13	infection	infection	NOUN
dti-2469	185	14	.	.	PUNCT
dti-2469	186	1	n	n	PROPN
dti-2469	186	2	engl	engl	PROPN
dti-2469	186	3	j	j	PROPN
dti-2469	186	4	med	med	PROPN
dti-2469	186	5	.	.	PUNCT
dti-2469	187	1	2015;372(16):1539	2015;372(16):1539	NOUN
dti-2469	187	2	-	-	SYM
dti-2469	187	3	1548	1548	NUM
dti-2469	187	4	.	.	PUNCT
dti-2469	188	1	crossref	crossref	PROPN
dti-2469	188	2	pubmed	pubmed	PROPN
dti-2469	188	3	3	3	PROPN
dti-2469	188	4	.	.	PUNCT
dti-2469	189	1	rupnik	rupnik	PROPN
dti-2469	189	2	m	m	PROPN
dti-2469	189	3	,	,	PUNCT
dti-2469	189	4	wilcox	wilcox	PROPN
dti-2469	189	5	mh	mh	PROPN
dti-2469	189	6	,	,	PUNCT
dti-2469	189	7	gerding	gerde	VERB
dti-2469	189	8	dn	dn	PROPN
dti-2469	189	9	.	.	PUNCT
dti-2469	189	10	clostridium	clostridium	NOUN
dti-2469	189	11	difficile	difficile	ADJ
dti-2469	189	12	infection	infection	NOUN
dti-2469	189	13	:	:	PUNCT
dti-2469	189	14	new	new	ADJ
dti-2469	189	15	developments	development	NOUN
dti-2469	189	16	in	in	ADP
dti-2469	189	17	epidemiology	epidemiology	NOUN
dti-2469	189	18	and	and	CCONJ
dti-2469	189	19	pathogenesis	pathogenesis	NOUN
dti-2469	189	20	.	.	PUNCT
dti-2469	190	1	nat	nat	PROPN
dti-2469	190	2	rev	rev	VERB
dti-2469	190	3	microbiol	microbiol	PROPN
dti-2469	190	4	.	.	PUNCT
dti-2469	191	1	2009;7(7):526	2009;7(7):526	X
dti-2469	191	2	-	-	SYM
dti-2469	191	3	536	536	NUM
dti-2469	191	4	.	.	PUNCT
dti-2469	192	1	crossref	crossref	PROPN
dti-2469	192	2	pubmed	pubmed	PROPN
dti-2469	192	3	4	4	PROPN
dti-2469	192	4	.	.	PUNCT
dti-2469	193	1	martin	martin	PROPN
dti-2469	193	2	js	js	PROPN
dti-2469	193	3	,	,	PUNCT
dti-2469	193	4	monaghan	monaghan	PROPN
dti-2469	193	5	tm	tm	PROPN
dti-2469	193	6	,	,	PUNCT
dti-2469	193	7	wilcox	wilcox	PROPN
dti-2469	193	8	mh	mh	PROPN
dti-2469	193	9	.	.	PUNCT
dti-2469	193	10	clostridium	clostridium	PROPN
dti-2469	193	11	difficile	difficile	ADJ
dti-2469	193	12	infection	infection	NOUN
dti-2469	193	13	:	:	PUNCT
dti-2469	193	14	epidemiology	epidemiology	NOUN
dti-2469	193	15	,	,	PUNCT
dti-2469	193	16	diagnosis	diagnosis	NOUN
dti-2469	193	17	and	and	CCONJ
dti-2469	193	18	understanding	understanding	NOUN
dti-2469	193	19	transmission	transmission	NOUN
dti-2469	193	20	.	.	PUNCT
dti-2469	194	1	nat	nat	PROPN
dti-2469	194	2	rev	rev	PROPN
dti-2469	194	3	gastroenterol	gastroenterol	NOUN
dti-2469	194	4	hepatol	hepatol	ADV
dti-2469	194	5	.	.	PUNCT
dti-2469	195	1	2016;13(4):206	2016;13(4):206	NOUN
dti-2469	195	2	-	-	SYM
dti-2469	195	3	216	216	NUM
dti-2469	195	4	.	.	PUNCT
dti-2469	196	1	crossref	crossref	PROPN
dti-2469	196	2	pubmed	pubmed	PROPN
dti-2469	196	3	5	5	PROPN
dti-2469	196	4	.	.	PUNCT
dti-2469	197	1	abt	abt	PROPN
dti-2469	197	2	mc	mc	PROPN
dti-2469	197	3	,	,	PUNCT
dti-2469	197	4	mckenney	mckenney	PROPN
dti-2469	197	5	pt	pt	PROPN
dti-2469	197	6	,	,	PUNCT
dti-2469	197	7	pamer	pamer	NOUN
dti-2469	197	8	eg	eg	NOUN
dti-2469	197	9	.	.	PUNCT
dti-2469	198	1	clostridium	clostridium	NOUN
dti-2469	198	2	difficile	difficile	ADJ
dti-2469	198	3	colitis	colitis	NOUN
dti-2469	198	4	:	:	PUNCT
dti-2469	198	5	pathogenesis	pathogenesis	NOUN
dti-2469	198	6	and	and	CCONJ
dti-2469	198	7	host	host	NOUN
dti-2469	198	8	defence	defence	NOUN
dti-2469	198	9	.	.	PUNCT
dti-2469	199	1	nat	nat	PROPN
dti-2469	199	2	rev	rev	PROPN
dti-2469	199	3	microbiol	microbiol	PROPN
dti-2469	199	4	.	.	PUNCT
dti-2469	200	1	2016	2016	NUM
dti-2469	200	2	;	;	PUNCT
dti-2469	200	3	14(10):609	14(10):609	NUM
dti-2469	200	4	-	-	SYM
dti-2469	200	5	620	620	NUM
dti-2469	200	6	.	.	PUNCT
dti-2469	201	1	crossref	crossref	PROPN
dti-2469	201	2	pubmed	pubmed	PROPN
dti-2469	201	3	6	6	NUM
dti-2469	201	4	.	.	PUNCT
dti-2469	202	1	lim	lim	PROPN
dti-2469	202	2	sc	sc	PROPN
dti-2469	202	3	,	,	PUNCT
dti-2469	202	4	knight	knight	PROPN
dti-2469	202	5	dr	dr	PROPN
dti-2469	202	6	,	,	PUNCT
dti-2469	202	7	riley	riley	PROPN
dti-2469	202	8	tv	tv	PROPN
dti-2469	202	9	.	.	PUNCT
dti-2469	203	1	clostridium	clostridium	NOUN
dti-2469	203	2	difficile	difficile	NOUN
dti-2469	203	3	and	and	CCONJ
dti-2469	203	4	one	one	NUM
dti-2469	203	5	health	health	NOUN
dti-2469	203	6	.	.	PUNCT
dti-2469	204	1	clin	clin	PROPN
dti-2469	204	2	microbiol	microbiol	PROPN
dti-2469	204	3	infect	infect	VERB
dti-2469	204	4	.	.	PUNCT
dti-2469	205	1	2020;26(7):857	2020;26(7):857	NOUN
dti-2469	205	2	-	-	NUM
dti-2469	205	3	863	863	NUM
dti-2469	205	4	.	.	PUNCT
dti-2469	206	1	crossref	crossref	PROPN
dti-2469	206	2	pubmed	pubmed	PROPN
dti-2469	206	3	7	7	PROPN
dti-2469	206	4	.	.	PUNCT
dti-2469	207	1	lessa	lessa	PROPN
dti-2469	207	2	fc	fc	PROPN
dti-2469	207	3	,	,	PUNCT
dti-2469	207	4	mu	mu	PROPN
dti-2469	207	5	y	y	PROPN
dti-2469	207	6	,	,	PUNCT
dti-2469	207	7	bamberg	bamberg	PROPN
dti-2469	207	8	wm	wm	PROPN
dti-2469	207	9	,	,	PUNCT
dti-2469	207	10	et	et	PROPN
dti-2469	207	11	al	al	PROPN
dti-2469	207	12	.	.	PUNCT
dti-2469	207	13	burden	burden	NOUN
dti-2469	207	14	of	of	ADP
dti-2469	207	15	clostridium	clostridium	NOUN
dti-2469	207	16	difficile	difficile	ADJ
dti-2469	207	17	infection	infection	NOUN
dti-2469	207	18	in	in	ADP
dti-2469	207	19	the	the	DET
dti-2469	207	20	united	united	PROPN
dti-2469	207	21	states	states	PROPN
dti-2469	207	22	.	.	PUNCT
dti-2469	208	1	n	n	PROPN
dti-2469	208	2	engl	engl	PROPN
dti-2469	208	3	j	j	PROPN
dti-2469	208	4	med	med	PROPN
dti-2469	208	5	.	.	PUNCT
dti-2469	209	1	2015;372(9	2015;372(9	NOUN
dti-2469	209	2	):	):	PUNCT
dti-2469	209	3	825	825	NUM
dti-2469	209	4	-	-	SYM
dti-2469	209	5	834	834	NUM
dti-2469	209	6	.	.	PUNCT
dti-2469	210	1	crossref	crossref	PROPN
dti-2469	210	2	pubmed	pubmed	PROPN
dti-2469	210	3	8	8	PROPN
dti-2469	210	4	.	.	PUNCT
dti-2469	211	1	seekatz	seekatz	PROPN
dti-2469	211	2	am	be	AUX
dti-2469	211	3	,	,	PUNCT
dti-2469	211	4	young	young	ADJ
dti-2469	211	5	vb	vb	PROPN
dti-2469	211	6	.	.	PUNCT
dti-2469	211	7	clostridium	clostridium	NOUN
dti-2469	211	8	difficile	difficile	NOUN
dti-2469	211	9	and	and	CCONJ
dti-2469	211	10	the	the	DET
dti-2469	211	11	microbiota	microbiota	NOUN
dti-2469	211	12	.	.	PUNCT
dti-2469	212	1	j	j	PROPN
dti-2469	212	2	clin	clin	PROPN
dti-2469	212	3	invest	invest	PROPN
dti-2469	212	4	.	.	PUNCT
dti-2469	213	1	2014;124(10):4182	2014;124(10):4182	NOUN
dti-2469	213	2	-	-	SYM
dti-2469	213	3	4189	4189	NUM
dti-2469	213	4	.	.	PUNCT
dti-2469	214	1	crossref	crossref	PROPN
dti-2469	214	2	pubmed	pubmed	PROPN
dti-2469	214	3	9	9	PROPN
dti-2469	214	4	.	.	PUNCT
dti-2469	214	5	hall	hall	PROPN
dti-2469	214	6	ic	ic	PROPN
dti-2469	214	7	,	,	PUNCT
dti-2469	214	8	o’toole	o’toole	PROPN
dti-2469	214	9	e.	e.	PROPN
dti-2469	214	10	intestinal	intestinal	ADJ
dti-2469	214	11	flora	flora	NOUN
dti-2469	214	12	in	in	ADP
dti-2469	214	13	new	new	ADV
dti-2469	214	14	-	-	PUNCT
dti-2469	214	15	born	bear	VERB
dti-2469	214	16	infants	infant	NOUN
dti-2469	214	17	:	:	PUNCT
dti-2469	214	18	with	with	ADP
dti-2469	214	19	a	a	DET
dti-2469	214	20	description	description	NOUN
dti-2469	214	21	of	of	ADP
dti-2469	214	22	a	a	DET
dti-2469	214	23	new	new	ADJ
dti-2469	214	24	pathogenic	pathogenic	ADJ
dti-2469	214	25	anaerobe	anaerobe	NOUN
dti-2469	214	26	,	,	PUNCT
dti-2469	214	27	bacillus	bacillus	NOUN
dti-2469	214	28	difficilis	difficili	NOUN
dti-2469	214	29	.	.	PUNCT
dti-2469	215	1	ama	ama	PROPN
dti-2469	215	2	am	be	AUX
dti-2469	215	3	j	j	PROPN
dti-2469	215	4	dis	dis	PROPN
dti-2469	215	5	child	child	NOUN
dti-2469	215	6	.	.	PUNCT
dti-2469	216	1	1935;49(2):390	1935;49(2):390	NUM
dti-2469	216	2	-	-	PUNCT
dti-2469	216	3	402	402	NUM
dti-2469	216	4	.	.	PUNCT
dti-2469	217	1	crossref	crossref	PROPN
dti-2469	217	2	10	10	NUM
dti-2469	217	3	.	.	PUNCT
dti-2469	218	1	bartlett	bartlett	PROPN
dti-2469	218	2	jg	jg	PROPN
dti-2469	218	3	,	,	PUNCT
dti-2469	218	4	moon	moon	PROPN
dti-2469	218	5	n	n	CCONJ
dti-2469	218	6	,	,	PUNCT
dti-2469	218	7	chang	chang	PROPN
dti-2469	218	8	tw	tw	PROPN
dti-2469	218	9	,	,	PUNCT
dti-2469	218	10	taylor	taylor	PROPN
dti-2469	218	11	n	n	CCONJ
dti-2469	218	12	,	,	PUNCT
dti-2469	218	13	onderdonk	onderdonk	PROPN
dti-2469	218	14	ab	ab	PROPN
dti-2469	218	15	.	.	PUNCT
dti-2469	218	16	role	role	NOUN
dti-2469	218	17	of	of	ADP
dti-2469	218	18	clostridium	clostridium	NOUN
dti-2469	218	19	difficile	difficile	ADJ
dti-2469	218	20	in	in	ADP
dti-2469	218	21	antibiotic	antibiotic	ADJ
dti-2469	218	22	-	-	PUNCT
dti-2469	218	23	associated	associate	VERB
dti-2469	218	24	pseudomembranous	pseudomembranous	ADJ
dti-2469	218	25	colitis	colitis	NOUN
dti-2469	218	26	.	.	PUNCT
dti-2469	219	1	gastroenterology	gastroenterology	NOUN
dti-2469	219	2	.	.	PUNCT
dti-2469	220	1	1978;75(5):778	1978;75(5):778	PROPN
dti-2469	220	2	-	-	PUNCT
dti-2469	220	3	782	782	PROPN
dti-2469	220	4	.	.	PUNCT
dti-2469	221	1	crossref	crossref	PROPN
dti-2469	221	2	pubmed	pubmed	PROPN
dti-2469	221	3	11	11	NUM
dti-2469	221	4	.	.	PUNCT
dti-2469	222	1	knight	knight	PROPN
dti-2469	222	2	dr	dr	PROPN
dti-2469	222	3	,	,	PUNCT
dti-2469	222	4	imwattana	imwattana	PROPN
dti-2469	222	5	k	k	PROPN
dti-2469	222	6	,	,	PUNCT
dti-2469	222	7	kullin	kullin	PROPN
dti-2469	222	8	b	b	PROPN
dti-2469	222	9	,	,	PUNCT
dti-2469	222	10	et	et	PROPN
dti-2469	222	11	al	al	PROPN
dti-2469	222	12	.	.	PUNCT
dti-2469	223	1	major	major	ADJ
dti-2469	223	2	genetic	genetic	ADJ
dti-2469	223	3	discontinuity	discontinuity	NOUN
dti-2469	223	4	and	and	CCONJ
dti-2469	223	5	novel	novel	ADJ
dti-2469	223	6	toxigenic	toxigenic	ADJ
dti-2469	223	7	species	specie	NOUN
dti-2469	223	8	in	in	ADP
dti-2469	223	9	clostridioides	clostridioide	NOUN
dti-2469	223	10	difficile	difficile	VERB
dti-2469	223	11	taxonomy	taxonomy	NOUN
dti-2469	223	12	.	.	PUNCT
dti-2469	224	1	elife	elife	NOUN
dti-2469	224	2	.	.	PUNCT
dti-2469	225	1	2021;10	2021;10	NUM
dti-2469	225	2	:	:	PUNCT
dti-2469	226	1	e64325	e64325	PROPN
dti-2469	226	2	.	.	PUNCT
dti-2469	226	3	crossref	crossref	PROPN
dti-2469	226	4	pubmed	pubmed	PROPN
dti-2469	226	5	12	12	NUM
dti-2469	226	6	.	.	PUNCT
dti-2469	227	1	vernikos	vernikos	PROPN
dti-2469	227	2	g	g	PROPN
dti-2469	227	3	,	,	PUNCT
dti-2469	227	4	medini	medini	PROPN
dti-2469	227	5	d	d	PROPN
dti-2469	227	6	,	,	PUNCT
dti-2469	227	7	riley	riley	PROPN
dti-2469	227	8	dr	dr	PROPN
dti-2469	227	9	,	,	PUNCT
dti-2469	227	10	tettelin	tettelin	PROPN
dti-2469	227	11	h.	h.	PROPN
dti-2469	227	12	ten	ten	NUM
dti-2469	227	13	years	year	NOUN
dti-2469	227	14	of	of	ADP
dti-2469	227	15	pangenome	pangenome	NOUN
dti-2469	227	16	analyses	analysis	NOUN
dti-2469	227	17	.	.	PUNCT
dti-2469	228	1	curr	curr	PROPN
dti-2469	228	2	opin	opin	PROPN
dti-2469	228	3	microbiol	microbiol	PROPN
dti-2469	228	4	.	.	PUNCT
dti-2469	229	1	2015;23:148	2015;23:148	PROPN
dti-2469	229	2	-	-	SYM
dti-2469	229	3	154	154	NUM
dti-2469	229	4	.	.	PUNCT
dti-2469	230	1	crossref	crossref	PROPN
dti-2469	230	2	pubmed	pubmed	PROPN
dti-2469	230	3	13	13	PROPN
dti-2469	230	4	.	.	PUNCT
dti-2469	231	1	tettelin	tettelin	PROPN
dti-2469	231	2	h	h	PROPN
dti-2469	231	3	,	,	PUNCT
dti-2469	231	4	masignani	masignani	PROPN
dti-2469	231	5	v	v	NOUN
dti-2469	231	6	,	,	PUNCT
dti-2469	231	7	cieslewicz	cieslewicz	PROPN
dti-2469	231	8	mj	mj	PROPN
dti-2469	231	9	,	,	PUNCT
dti-2469	231	10	et	et	PROPN
dti-2469	231	11	al	al	PROPN
dti-2469	231	12	.	.	PROPN
dti-2469	231	13	genome	genome	NOUN
dti-2469	231	14	analysis	analysis	NOUN
dti-2469	231	15	of	of	ADP
dti-2469	231	16	multiple	multiple	ADJ
dti-2469	231	17	pathogenic	pathogenic	ADJ
dti-2469	231	18	isolates	isolate	NOUN
dti-2469	231	19	of	of	ADP
dti-2469	231	20	streptococcus	streptococcus	NOUN
dti-2469	231	21	agalactiae	agalactiae	NOUN
dti-2469	231	22	:	:	PUNCT
dti-2469	231	23	implications	implication	NOUN
dti-2469	231	24	for	for	ADP
dti-2469	231	25	the	the	DET
dti-2469	231	26	microbial	microbial	ADJ
dti-2469	231	27	“	"	PUNCT
dti-2469	231	28	pan	pan	NOUN
dti-2469	231	29	-	-	NOUN
dti-2469	231	30	genome	genome	NOUN
dti-2469	231	31	”	"	PUNCT
dti-2469	231	32	.	.	PUNCT
dti-2469	232	1	proc	proc	PROPN
dti-2469	232	2	natl	natl	PROPN
dti-2469	232	3	acad	acad	PROPN
dti-2469	232	4	sci	sci	PROPN
dti-2469	232	5	usa	usa	PROPN
dti-2469	232	6	.	.	PROPN
dti-2469	233	1	2005;102(39):13950	2005;102(39):13950	NUM
dti-2469	233	2	-	-	PROPN
dti-2469	233	3	13955	13955	NUM
dti-2469	233	4	.	.	PUNCT
dti-2469	234	1	crossref	crossref	PROPN
dti-2469	234	2	pubmed	pubmed	PROPN
dti-2469	234	3	14	14	NUM
dti-2469	234	4	.	.	PUNCT
dti-2469	235	1	croll	croll	PROPN
dti-2469	235	2	d	d	PROPN
dti-2469	235	3	,	,	PUNCT
dti-2469	235	4	mcdonald	mcdonald	PROPN
dti-2469	235	5	ba	ba	PROPN
dti-2469	235	6	.	.	PUNCT
dti-2469	236	1	the	the	DET
dti-2469	236	2	accessory	accessory	NOUN
dti-2469	236	3	genome	genome	NOUN
dti-2469	236	4	as	as	ADP
dti-2469	236	5	a	a	DET
dti-2469	236	6	cradle	cradle	NOUN
dti-2469	236	7	for	for	ADP
dti-2469	236	8	adaptive	adaptive	ADJ
dti-2469	236	9	evolution	evolution	NOUN
dti-2469	236	10	in	in	ADP
dti-2469	236	11	pathogens	pathogen	NOUN
dti-2469	236	12	.	.	PUNCT
dti-2469	237	1	plos	plos	PROPN
dti-2469	237	2	pathog	pathog	PROPN
dti-2469	237	3	.	.	PUNCT
dti-2469	238	1	2012;8(4	2012;8(4	NUM
dti-2469	238	2	):	):	PUNCT
dti-2469	238	3	e1002608	e1002608	NOUN
dti-2469	238	4	.	.	PUNCT
dti-2469	239	1	crossref	crossref	PROPN
dti-2469	239	2	pubmed	pubmed	PROPN
dti-2469	239	3	15	15	PROPN
dti-2469	239	4	.	.	PUNCT
dti-2469	240	1	katsila	katsila	PROPN
dti-2469	240	2	t	t	PROPN
dti-2469	240	3	,	,	PUNCT
dti-2469	240	4	spyroulias	spyroulias	PROPN
dti-2469	240	5	ga	ga	PROPN
dti-2469	240	6	,	,	PUNCT
dti-2469	240	7	patrinos	patrinos	PROPN
dti-2469	240	8	gp	gp	NOUN
dti-2469	240	9	,	,	PUNCT
dti-2469	240	10	matsoukas	matsoukas	PROPN
dti-2469	240	11	mt	mt	PROPN
dti-2469	240	12	.	.	PROPN
dti-2469	240	13	computational	computational	ADJ
dti-2469	240	14	approaches	approach	NOUN
dti-2469	240	15	in	in	ADP
dti-2469	240	16	target	target	NOUN
dti-2469	240	17	identification	identification	NOUN
dti-2469	240	18	and	and	CCONJ
dti-2469	240	19	drug	drug	NOUN
dti-2469	240	20	discovery	discovery	NOUN
dti-2469	240	21	.	.	PUNCT
dti-2469	241	1	comput	comput	PROPN
dti-2469	241	2	struct	struct	VERB
dti-2469	241	3	biotechnol	biotechnol	ADJ
dti-2469	241	4	j.	j.	PROPN
dti-2469	241	5	2016;14:177	2016;14:177	PROPN
dti-2469	241	6	-	-	SYM
dti-2469	241	7	184	184	NUM
dti-2469	241	8	.	.	PUNCT
dti-2469	242	1	crossref	crossref	PROPN
dti-2469	242	2	pubmed	pubmed	PROPN
dti-2469	242	3	16	16	NUM
dti-2469	242	4	.	.	PUNCT
dti-2469	243	1	sayers	sayer	NOUN
dti-2469	243	2	ew	ew	PROPN
dti-2469	243	3	,	,	PUNCT
dti-2469	243	4	beck	beck	PROPN
dti-2469	243	5	j	j	PROPN
dti-2469	243	6	,	,	PUNCT
dti-2469	243	7	bolton	bolton	PROPN
dti-2469	243	8	ee	ee	PROPN
dti-2469	243	9	,	,	PUNCT
dti-2469	243	10	et	et	PROPN
dti-2469	243	11	al	al	PROPN
dti-2469	243	12	.	.	PUNCT
dti-2469	244	1	database	database	NOUN
dti-2469	244	2	resources	resource	NOUN
dti-2469	244	3	of	of	ADP
dti-2469	244	4	the	the	DET
dti-2469	244	5	national	national	ADJ
dti-2469	244	6	center	center	NOUN
dti-2469	244	7	for	for	ADP
dti-2469	244	8	biotechnology	biotechnology	NOUN
dti-2469	244	9	information	information	NOUN
dti-2469	244	10	.	.	PUNCT
dti-2469	245	1	nucleic	nucleic	ADJ
dti-2469	245	2	acids	acid	NOUN
dti-2469	245	3	res	re	NOUN
dti-2469	245	4	.	.	PUNCT
dti-2469	246	1	2021;49(d1):d10	2021;49(d1):d10	NUM
dti-2469	246	2	-	-	PUNCT
dti-2469	246	3	d17	d17	NOUN
dti-2469	246	4	.	.	PUNCT
dti-2469	247	1	crossref	crossref	PROPN
dti-2469	247	2	pubmed	pubmed	PROPN
dti-2469	247	3	17	17	NUM
dti-2469	247	4	.	.	PUNCT
dti-2469	248	1	chaudhari	chaudhari	PROPN
dti-2469	248	2	nm	nm	PROPN
dti-2469	248	3	,	,	PUNCT
dti-2469	248	4	gupta	gupta	PROPN
dti-2469	248	5	vk	vk	VERB
dti-2469	248	6	,	,	PUNCT
dti-2469	248	7	dutta	dutta	PROPN
dti-2469	248	8	c.	c.	PROPN
dti-2469	248	9	bpga	bpga	PROPN
dti-2469	248	10	–	–	PUNCT
dti-2469	248	11	an	an	DET
dti-2469	248	12	ultra	ultra	ADJ
dti-2469	248	13	-	-	ADJ
dti-2469	248	14	fast	fast	ADJ
dti-2469	248	15	pangenome	pangenome	NOUN
dti-2469	248	16	analysis	analysis	NOUN
dti-2469	248	17	pipeline	pipeline	NOUN
dti-2469	248	18	.	.	PUNCT
dti-2469	249	1	sci	sci	PROPN
dti-2469	249	2	rep	rep	PROPN
dti-2469	249	3	.	.	PROPN
dti-2469	249	4	2016;6(1):24373	2016;6(1):24373	NUM
dti-2469	249	5	.	.	PUNCT
dti-2469	250	1	crossref	crossref	PROPN
dti-2469	250	2	pubmed	pubmed	PROPN
dti-2469	250	3	18	18	NUM
dti-2469	250	4	.	.	PUNCT
dti-2469	251	1	edgar	edgar	PROPN
dti-2469	251	2	rc	rc	PROPN
dti-2469	251	3	.	.	PUNCT
dti-2469	251	4	search	search	PROPN
dti-2469	251	5	and	and	CCONJ
dti-2469	251	6	clustering	clustering	ADJ
dti-2469	251	7	orders	order	NOUN
dti-2469	251	8	of	of	ADP
dti-2469	251	9	magnitude	magnitude	NOUN
dti-2469	251	10	faster	fast	ADV
dti-2469	251	11	than	than	ADP
dti-2469	251	12	blast	blast	NOUN
dti-2469	251	13	.	.	PUNCT
dti-2469	252	1	bioinformatics	bioinformatic	NOUN
dti-2469	252	2	.	.	PUNCT
dti-2469	253	1	2010;26(19):2460	2010;26(19):2460	NUM
dti-2469	253	2	-	-	SYM
dti-2469	253	3	2461	2461	NUM
dti-2469	253	4	.	.	PUNCT
dti-2469	254	1	crossref	crossref	PROPN
dti-2469	254	2	pubmed	pubmed	PROPN
dti-2469	254	3	19	19	NUM
dti-2469	254	4	.	.	PUNCT
dti-2469	255	1	kanehisa	kanehisa	PROPN
dti-2469	255	2	m	m	PROPN
dti-2469	255	3	,	,	PUNCT
dti-2469	255	4	goto	goto	ADJ
dti-2469	255	5	s.	s.	PROPN
dti-2469	255	6	kegg	kegg	PROPN
dti-2469	255	7	:	:	PUNCT
dti-2469	255	8	kyoto	kyoto	PROPN
dti-2469	255	9	encyclopedia	encyclopedia	NOUN
dti-2469	255	10	of	of	ADP
dti-2469	255	11	genes	gene	NOUN
dti-2469	255	12	and	and	CCONJ
dti-2469	255	13	genomes	genome	NOUN
dti-2469	255	14	.	.	PUNCT
dti-2469	256	1	nucleic	nucleic	ADJ
dti-2469	256	2	acids	acid	NOUN
dti-2469	256	3	res	re	NOUN
dti-2469	256	4	.	.	PUNCT
dti-2469	257	1	2000;28(1):27	2000;28(1):27	NUM
dti-2469	257	2	-	-	SYM
dti-2469	257	3	30	30	NUM
dti-2469	257	4	.	.	PUNCT
dti-2469	258	1	crossref	crossref	PROPN
dti-2469	258	2	pubmed	pubmed	PROPN
dti-2469	258	3	20	20	NUM
dti-2469	258	4	.	.	PUNCT
dti-2469	259	1	tatusov	tatusov	PROPN
dti-2469	259	2	rl	rl	PROPN
dti-2469	259	3	,	,	PUNCT
dti-2469	259	4	fedorova	fedorova	PROPN
dti-2469	259	5	nd	nd	PROPN
dti-2469	259	6	,	,	PUNCT
dti-2469	259	7	jackson	jackson	PROPN
dti-2469	259	8	jd	jd	PROPN
dti-2469	259	9	,	,	PUNCT
dti-2469	259	10	et	et	PROPN
dti-2469	259	11	al	al	PROPN
dti-2469	259	12	.	.	PUNCT
dti-2469	260	1	the	the	DET
dti-2469	260	2	cog	cog	PROPN
dti-2469	260	3	database	database	PROPN
dti-2469	260	4	:	:	PUNCT
dti-2469	260	5	an	an	DET
dti-2469	260	6	updated	update	VERB
dti-2469	260	7	version	version	NOUN
dti-2469	260	8	includes	include	VERB
dti-2469	260	9	eukaryotes	eukaryote	NOUN
dti-2469	260	10	.	.	PUNCT
dti-2469	261	1	bmc	bmc	ADJ
dti-2469	261	2	bioinformatics	bioinformatics	NOUN
dti-2469	261	3	.	.	PUNCT
dti-2469	262	1	2003;4(1):41	2003;4(1):41	NUM
dti-2469	262	2	.	.	PUNCT
dti-2469	262	3	crossref	crossref	PROPN
dti-2469	262	4	pubmed	pubmed	PROPN
dti-2469	262	5	21	21	NUM
dti-2469	262	6	.	.	PUNCT
dti-2469	263	1	ye	ye	PRON
dti-2469	263	2	j	j	PROPN
dti-2469	263	3	,	,	PUNCT
dti-2469	263	4	mcginnis	mcginnis	PROPN
dti-2469	263	5	s	s	PROPN
dti-2469	263	6	,	,	PUNCT
dti-2469	263	7	madden	madden	PROPN
dti-2469	263	8	tl	tl	PROPN
dti-2469	263	9	.	.	PUNCT
dti-2469	263	10	blast	blast	PROPN
dti-2469	263	11	:	:	PUNCT
dti-2469	263	12	improvements	improvement	NOUN
dti-2469	263	13	for	for	ADP
dti-2469	263	14	better	well	ADJ
dti-2469	263	15	sequence	sequence	NOUN
dti-2469	263	16	analysis	analysis	NOUN
dti-2469	263	17	.	.	PUNCT
dti-2469	264	1	nucleic	nucleic	ADJ
dti-2469	264	2	acids	acid	NOUN
dti-2469	264	3	res	re	NOUN
dti-2469	264	4	.	.	PUNCT
dti-2469	265	1	2006;34(web	2006;34(web	NUM
dti-2469	265	2	server	server	NOUN
dti-2469	265	3	issue):w6	issue):w6	NOUN
dti-2469	265	4	-	-	PUNCT
dti-2469	265	5	9	9	NUM
dti-2469	265	6	.	.	PUNCT
dti-2469	265	7	pubmed	pubmed	PROPN
dti-2469	265	8	22	22	NUM
dti-2469	265	9	.	.	PUNCT
dti-2469	266	1	luo	luo	PROPN
dti-2469	266	2	h	h	PROPN
dti-2469	266	3	,	,	PUNCT
dti-2469	266	4	lin	lin	PROPN
dti-2469	266	5	y	y	PROPN
dti-2469	266	6	,	,	PUNCT
dti-2469	266	7	liu	liu	PROPN
dti-2469	266	8	t	t	PROPN
dti-2469	266	9	,	,	PUNCT
dti-2469	266	10	et	et	PROPN
dti-2469	266	11	al	al	PROPN
dti-2469	266	12	.	.	PROPN
dti-2469	266	13	deg	deg	PROPN
dti-2469	266	14	15	15	NUM
dti-2469	266	15	,	,	PUNCT
dti-2469	266	16	an	an	DET
dti-2469	266	17	update	update	NOUN
dti-2469	266	18	of	of	ADP
dti-2469	266	19	the	the	DET
dti-2469	266	20	database	database	NOUN
dti-2469	266	21	of	of	ADP
dti-2469	266	22	essential	essential	ADJ
dti-2469	266	23	genes	gene	NOUN
dti-2469	266	24	that	that	PRON
dti-2469	266	25	includes	include	VERB
dti-2469	266	26	built	build	VERB
dti-2469	266	27	-	-	PUNCT
dti-2469	266	28	in	in	ADP
dti-2469	266	29	analysis	analysis	NOUN
dti-2469	266	30	tools	tool	NOUN
dti-2469	266	31	.	.	PUNCT
dti-2469	267	1	nucleic	nucleic	ADJ
dti-2469	267	2	acids	acid	NOUN
dti-2469	267	3	res	re	NOUN
dti-2469	267	4	.	.	PUNCT
dti-2469	268	1	2021;49(d1):d677	2021;49(d1):d677	NUM
dti-2469	268	2	-	-	PUNCT
dti-2469	268	3	d686	d686	PROPN
dti-2469	268	4	.	.	PUNCT
dti-2469	268	5	crossref	crossref	PROPN
dti-2469	268	6	pubmed	pubmed	PROPN
dti-2469	268	7	23	23	NUM
dti-2469	268	8	.	.	PUNCT
dti-2469	269	1	liu	liu	PROPN
dti-2469	269	2	b	b	PROPN
dti-2469	269	3	,	,	PUNCT
dti-2469	269	4	zheng	zheng	PROPN
dti-2469	269	5	d	d	PROPN
dti-2469	269	6	,	,	PUNCT
dti-2469	269	7	jin	jin	PROPN
dti-2469	269	8	q	q	PROPN
dti-2469	269	9	,	,	PUNCT
dti-2469	269	10	chen	chen	PROPN
dti-2469	269	11	l	l	PROPN
dti-2469	269	12	,	,	PUNCT
dti-2469	269	13	yang	yang	PROPN
dti-2469	269	14	j.	j.	PROPN
dti-2469	269	15	vfdb	vfdb	PROPN
dti-2469	269	16	2019	2019	NUM
dti-2469	269	17	:	:	PUNCT
dti-2469	269	18	a	a	DET
dti-2469	269	19	comparative	comparative	ADJ
dti-2469	269	20	pathogenomic	pathogenomic	ADJ
dti-2469	269	21	platform	platform	NOUN
dti-2469	269	22	with	with	ADP
dti-2469	269	23	an	an	DET
dti-2469	269	24	interactive	interactive	ADJ
dti-2469	269	25	web	web	NOUN
dti-2469	269	26	interface	interface	NOUN
dti-2469	269	27	.	.	PUNCT
dti-2469	270	1	nucleic	nucleic	ADJ
dti-2469	270	2	acids	acid	NOUN
dti-2469	270	3	res	re	NOUN
dti-2469	270	4	.	.	PUNCT
dti-2469	271	1	2019;47(d1):d687	2019;47(d1):d687	X
dti-2469	271	2	-	-	PUNCT
dti-2469	271	3	d692	d692	PROPN
dti-2469	271	4	.	.	PUNCT
dti-2469	271	5	crossref	crossref	PROPN
dti-2469	271	6	pubmed	pubmed	PROPN
dti-2469	271	7	24	24	NUM
dti-2469	271	8	.	.	PUNCT
dti-2469	272	1	gasteiger	gasteiger	NOUN
dti-2469	272	2	e	e	NOUN
dti-2469	272	3	,	,	PUNCT
dti-2469	272	4	hoogland	hoogland	NOUN
dti-2469	272	5	c	c	NOUN
dti-2469	272	6	,	,	PUNCT
dti-2469	272	7	gattiker	gattiker	PROPN
dti-2469	272	8	a	a	NOUN
dti-2469	272	9	,	,	PUNCT
dti-2469	272	10	et	et	PROPN
dti-2469	272	11	al	al	PROPN
dti-2469	272	12	.	.	PUNCT
dti-2469	272	13	protein	protein	NOUN
dti-2469	272	14	identification	identification	NOUN
dti-2469	272	15	and	and	CCONJ
dti-2469	272	16	analysis	analysis	NOUN
dti-2469	272	17	tools	tool	NOUN
dti-2469	272	18	on	on	ADP
dti-2469	272	19	the	the	DET
dti-2469	272	20	expasy	expasy	ADJ
dti-2469	272	21	server	server	NOUN
dti-2469	272	22	.	.	PUNCT
dti-2469	273	1	the	the	DET
dti-2469	273	2	proteomics	proteomic	NOUN
dti-2469	273	3	protocols	protocol	NOUN
dti-2469	273	4	handbook	handbook	VERB
dti-2469	273	5	2005	2005	NUM
dti-2469	273	6	;	;	PUNCT
dti-2469	273	7	571	571	NUM
dti-2469	273	8	-	-	SYM
dti-2469	273	9	607	607	NUM
dti-2469	273	10	.	.	PUNCT
dti-2469	274	1	crossref	crossref	PROPN
dti-2469	274	2	25	25	NUM
dti-2469	274	3	.	.	PUNCT
dti-2469	274	4	yu	yu	PROPN
dti-2469	275	1	cs	cs	PROPN
dti-2469	275	2	,	,	PUNCT
dti-2469	275	3	chen	chen	PROPN
dti-2469	275	4	yc	yc	PROPN
dti-2469	275	5	,	,	PUNCT
dti-2469	275	6	lu	lu	PROPN
dti-2469	275	7	ch	ch	PROPN
dti-2469	275	8	,	,	PUNCT
dti-2469	275	9	hwang	hwang	PROPN
dti-2469	275	10	jk	jk	PROPN
dti-2469	275	11	.	.	PUNCT
dti-2469	275	12	prediction	prediction	NOUN
dti-2469	275	13	of	of	ADP
dti-2469	275	14	protein	protein	NOUN
dti-2469	275	15	subcellular	subcellular	ADJ
dti-2469	275	16	localization	localization	NOUN
dti-2469	275	17	.	.	PUNCT
dti-2469	276	1	proteins	protein	NOUN
dti-2469	276	2	.	.	PUNCT
dti-2469	277	1	2006;64(3):643	2006;64(3):643	NOUN
dti-2469	277	2	-	-	SYM
dti-2469	277	3	651	651	NUM
dti-2469	277	4	.	.	PUNCT
dti-2469	278	1	crossref	crossref	PROPN
dti-2469	278	2	pubmed	pubmed	PROPN
dti-2469	278	3	26	26	NUM
dti-2469	278	4	.	.	PUNCT
dti-2469	279	1	gashaw	gashaw	PROPN
dti-2469	279	2	i	i	PRON
dti-2469	279	3	,	,	PUNCT
dti-2469	279	4	ellinghaus	ellinghaus	PROPN
dti-2469	279	5	p	p	NOUN
dti-2469	279	6	,	,	PUNCT
dti-2469	279	7	sommer	sommer	NOUN
dti-2469	279	8	a	a	X
dti-2469	279	9	,	,	PUNCT
dti-2469	279	10	asadullah	asadullah	PROPN
dti-2469	279	11	k.	k.	PROPN
dti-2469	280	1	what	what	PRON
dti-2469	280	2	makes	make	VERB
dti-2469	280	3	a	a	DET
dti-2469	280	4	good	good	ADJ
dti-2469	280	5	drug	drug	NOUN
dti-2469	280	6	target	target	NOUN
dti-2469	280	7	?	?	PUNCT
dti-2469	281	1	drug	drug	NOUN
dti-2469	281	2	discov	discov	NOUN
dti-2469	281	3	today	today	NOUN
dti-2469	281	4	.	.	PUNCT
dti-2469	282	1	2011;16(23	2011;16(23	NUM
dti-2469	282	2	-	-	SYM
dti-2469	282	3	24):10371043	24):10371043	NUM
dti-2469	282	4	.	.	PUNCT
dti-2469	283	1	crossref	crossref	PROPN
dti-2469	283	2	pubmed	pubmed	PROPN
dti-2469	283	3	27	27	NUM
dti-2469	283	4	.	.	PUNCT
dti-2469	284	1	bakheet	bakheet	PROPN
dti-2469	284	2	tm	tm	PROPN
dti-2469	284	3	,	,	PUNCT
dti-2469	284	4	doig	doig	PROPN
dti-2469	284	5	aj	aj	PROPN
dti-2469	284	6	.	.	PUNCT
dti-2469	285	1	properties	property	NOUN
dti-2469	285	2	and	and	CCONJ
dti-2469	285	3	identification	identification	NOUN
dti-2469	285	4	of	of	ADP
dti-2469	285	5	human	human	ADJ
dti-2469	285	6	protein	protein	NOUN
dti-2469	285	7	drug	drug	NOUN
dti-2469	285	8	targets	target	NOUN
dti-2469	285	9	.	.	PUNCT
dti-2469	286	1	bioinformatics	bioinformatic	NOUN
dti-2469	286	2	.	.	PUNCT
dti-2469	287	1	2009;25(4):451	2009;25(4):451	NUM
dti-2469	287	2	-	-	PUNCT
dti-2469	287	3	457	457	NUM
dti-2469	287	4	.	.	PUNCT
dti-2469	288	1	crossref	crossref	PROPN
dti-2469	288	2	pubmed	pubmed	PROPN
dti-2469	288	3	28	28	PROPN
dti-2469	288	4	.	.	PUNCT
dti-2469	289	1	solanki	solanki	PROPN
dti-2469	289	2	v	v	PROPN
dti-2469	289	3	,	,	PUNCT
dti-2469	289	4	tiwari	tiwari	ADJ
dti-2469	289	5	v.	v.	ADP
dti-2469	289	6	subtractive	subtractive	ADJ
dti-2469	289	7	proteomics	proteomic	NOUN
dti-2469	289	8	to	to	PART
dti-2469	289	9	identify	identify	VERB
dti-2469	289	10	novel	novel	ADJ
dti-2469	289	11	drug	drug	NOUN
dti-2469	289	12	targets	target	NOUN
dti-2469	289	13	and	and	CCONJ
dti-2469	289	14	reverse	reverse	ADJ
dti-2469	289	15	vaccinology	vaccinology	NOUN
dti-2469	289	16	for	for	ADP
dti-2469	289	17	the	the	DET
dti-2469	289	18	development	development	NOUN
dti-2469	289	19	of	of	ADP
dti-2469	289	20	chimeric	chimeric	ADJ
dti-2469	289	21	vaccine	vaccine	NOUN
dti-2469	289	22	against	against	ADP
dti-2469	289	23	acinetobacter	acinetobacter	ADJ
dti-2469	289	24	baumannii	baumannii	PROPN
dti-2469	289	25	.	.	PUNCT
dti-2469	290	1	sci	sci	PROPN
dti-2469	290	2	rep	rep	PROPN
dti-2469	290	3	.	.	PROPN
dti-2469	290	4	2018;8(1):9044	2018;8(1):9044	NUM
dti-2469	290	5	.	.	PUNCT
dti-2469	290	6	crossref	crossref	PROPN
dti-2469	290	7	pubmed	pubmed	PROPN
dti-2469	290	8	29	29	NUM
dti-2469	290	9	.	.	PUNCT
dti-2469	291	1	chang	chang	PROPN
dti-2469	291	2	ky	ky	PROPN
dti-2469	291	3	,	,	PUNCT
dti-2469	291	4	yang	yang	PROPN
dti-2469	291	5	jr	jr	PROPN
dti-2469	291	6	.	.	PUNCT
dti-2469	291	7	analysis	analysis	NOUN
dti-2469	291	8	and	and	CCONJ
dti-2469	291	9	prediction	prediction	NOUN
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dti-2469	291	11	highly	highly	ADV
dti-2469	291	12	effective	effective	ADJ
dti-2469	291	13	antiviral	antiviral	ADJ
dti-2469	291	14	peptides	peptide	NOUN
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dti-2469	292	1	plos	plos	PROPN
dti-2469	292	2	one	one	NUM
dti-2469	292	3	.	.	PUNCT
dti-2469	293	1	2013;8(8):e70166	2013;8(8):e70166	NUM
dti-2469	293	2	.	.	PUNCT
dti-2469	294	1	crossref	crossref	PROPN
dti-2469	294	2	pubmed	pubmed	PROPN
dti-2469	294	3	30	30	NUM
dti-2469	294	4	.	.	PUNCT
dti-2469	295	1	kumar	kumar	PROPN
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dti-2469	295	7	vyawahare	vyawahare	VERB
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dti-2469	295	9	,	,	PUNCT
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dti-2469	295	11	r.	r.	PROPN
dti-2469	295	12	membrane	membrane	NOUN
dti-2469	295	13	trafficking	trafficking	NOUN
dti-2469	295	14	and	and	CCONJ
dti-2469	295	15	subcellular	subcellular	ADJ
dti-2469	295	16	drug	drug	NOUN
dti-2469	295	17	targeting	target	VERB
dti-2469	295	18	pathways	pathway	NOUN
dti-2469	295	19	.	.	PUNCT
dti-2469	296	1	front	front	ADJ
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dti-2469	296	3	.	.	PUNCT
dti-2469	297	1	2020;11:629	2020;11:629	NUM
dti-2469	297	2	.	.	PUNCT
dti-2469	297	3	crossref	crossref	PROPN
dti-2469	297	4	pubmed	pubmed	PROPN
dti-2469	297	5	31	31	NUM
dti-2469	297	6	.	.	PUNCT
dti-2469	298	1	karp	karp	PROPN
dti-2469	298	2	pd	pd	PROPN
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dti-2469	298	6	,	,	PUNCT
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dti-2469	298	8	p.	p.	PROPN
dti-2469	298	9	the	the	DET
dti-2469	298	10	pathway	pathway	NOUN
dti-2469	298	11	tools	tool	NOUN
dti-2469	298	12	software	software	NOUN
dti-2469	298	13	.	.	PUNCT
dti-2469	299	1	bioinformatics	bioinformatic	NOUN
dti-2469	299	2	.	.	PUNCT
dti-2469	300	1	2002;18(suppl	2002;18(suppl	NOUN
dti-2469	300	2	1):s225	1):s225	NUM
dti-2469	300	3	-	-	SYM
dti-2469	300	4	s232	s232	PROPN
dti-2469	300	5	.	.	PUNCT
dti-2469	301	1	crossref	crossref	PROPN
dti-2469	301	2	pubmed	pubmed	PROPN
dti-2469	301	3	32	32	NUM
dti-2469	301	4	.	.	PUNCT
dti-2469	302	1	szklarczyk	szklarczyk	PROPN
dti-2469	302	2	d	d	X
dti-2469	302	3	,	,	PUNCT
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dti-2469	302	6	,	,	PUNCT
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dti-2469	302	8	h	h	NOUN
dti-2469	302	9	,	,	PUNCT
dti-2469	302	10	et	et	PROPN
dti-2469	302	11	al	al	PROPN
dti-2469	302	12	.	.	PUNCT
dti-2469	303	1	the	the	DET
dti-2469	303	2	string	string	NOUN
dti-2469	303	3	database	database	NOUN
dti-2469	303	4	in	in	ADP
dti-2469	303	5	2017	2017	NUM
dti-2469	303	6	:	:	PUNCT
dti-2469	303	7	quality	quality	NOUN
dti-2469	303	8	-	-	PUNCT
dti-2469	303	9	controlled	control	VERB
dti-2469	303	10	protein	protein	NOUN
dti-2469	303	11	–	–	PUNCT
dti-2469	303	12	protein	protein	NOUN
dti-2469	303	13	association	association	NOUN
dti-2469	303	14	networks	network	NOUN
dti-2469	303	15	,	,	PUNCT
dti-2469	303	16	made	make	VERB
dti-2469	303	17	broadly	broadly	ADV
dti-2469	303	18	accessible	accessible	ADJ
dti-2469	303	19	.	.	PUNCT
dti-2469	304	1	nucleic	nucleic	ADJ
dti-2469	304	2	acids	acid	NOUN
dti-2469	304	3	res	re	NOUN
dti-2469	304	4	.	.	PROPN
dti-2469	304	5	2017	2017	NUM
dti-2469	304	6	jan	jan	PROPN
dti-2469	304	7	4;45(d1):d362	4;45(d1):d362	PROPN
dti-2469	304	8	-	-	PUNCT
dti-2469	304	9	d368	d368	PROPN
dti-2469	304	10	.	.	PUNCT
dti-2469	305	1	crossref	crossref	PROPN
dti-2469	305	2	pubmed	pubmed	PROPN
dti-2469	305	3	33	33	NUM
dti-2469	305	4	.	.	PUNCT
dti-2469	306	1	demchak	demchak	PROPN
dti-2469	306	2	b	b	PROPN
dti-2469	306	3	,	,	PUNCT
dti-2469	306	4	hull	hull	PROPN
dti-2469	306	5	t	t	PROPN
dti-2469	306	6	,	,	PUNCT
dti-2469	306	7	reich	reich	PROPN
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dti-2469	306	10	et	et	PROPN
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dti-2469	306	12	.	.	PROPN
dti-2469	306	13	cytoscape	cytoscape	PROPN
dti-2469	306	14	:	:	PUNCT
dti-2469	306	15	the	the	DET
dti-2469	306	16	network	network	NOUN
dti-2469	306	17	visualization	visualization	NOUN
dti-2469	306	18	tool	tool	NOUN
dti-2469	306	19	for	for	ADP
dti-2469	306	20	genomespace	genomespace	NOUN
dti-2469	306	21	workflows	workflow	NOUN
dti-2469	306	22	.	.	PUNCT
dti-2469	307	1	f1000	f1000	PROPN
dti-2469	307	2	res	re	NOUN
dti-2469	307	3	.	.	PUNCT
dti-2469	307	4	2014	2014	NUM
dti-2469	307	5	;	;	PUNCT
dti-2469	307	6	3:151	3:151	NUM
dti-2469	307	7	.	.	PUNCT
dti-2469	308	1	crossref	crossref	PROPN
dti-2469	308	2	pubmed	pubmed	PROPN
dti-2469	308	3	34	34	NUM
dti-2469	308	4	.	.	PUNCT
dti-2469	309	1	kulecka	kulecka	PROPN
dti-2469	309	2	m	m	PROPN
dti-2469	309	3	,	,	PUNCT
dti-2469	309	4	waker	waker	PROPN
dti-2469	309	5	e	e	PROPN
dti-2469	309	6	,	,	PUNCT
dti-2469	309	7	ambrozkiewicz	ambrozkiewicz	PROPN
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dti-2469	309	9	,	,	PUNCT
dti-2469	309	10	et	et	PROPN
dti-2469	309	11	al	al	PROPN
dti-2469	309	12	.	.	PUNCT
dti-2469	309	13	higher	high	ADJ
dti-2469	309	14	genome	genome	NOUN
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dti-2469	309	19	associates	associate	NOUN
dti-2469	309	20	with	with	ADP
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dti-2469	309	22	clostridium	clostridium	NOUN
dti-2469	309	23	difficile	difficile	ADJ
dti-2469	309	24	infection	infection	NOUN
dti-2469	309	25	.	.	PUNCT
dti-2469	310	1	bmc	bmc	PROPN
dti-2469	310	2	microbiol	microbiol	PROPN
dti-2469	310	3	.	.	PUNCT
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dti-2469	311	4	pubmed	pubmed	PROPN
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dti-2469	311	6	.	.	PUNCT
dti-2469	312	1	sahr	sahr	PROPN
dti-2469	312	2	t	t	PROPN
dti-2469	312	3	,	,	PUNCT
dti-2469	312	4	ravanel	ravanel	NOUN
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dti-2469	312	6	,	,	PUNCT
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dti-2469	312	9	,	,	PUNCT
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dti-2469	312	12	,	,	PUNCT
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dti-2469	312	15	,	,	PUNCT
dti-2469	312	16	rébeillé	rébeillé	NOUN
dti-2469	312	17	f.	f.	PROPN
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dti-2469	312	19	synthesis	synthesis	NOUN
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dti-2469	312	22	:	:	PUNCT
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dti-2469	312	25	kinetic	kinetic	ADJ
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dti-2469	312	28	and	and	CCONJ
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dti-2469	312	30	https://www.ncbi.nlm.nih.gov/pubmed/29473021	https://www.ncbi.nlm.nih.gov/pubmed/29473021	NUM
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dti-2469	312	38	https://www.ncbi.nlm.nih.gov/pubmed/27573580	https://www.ncbi.nlm.nih.gov/pubmed/27573580	X
dti-2469	312	39	https://doi.org/10.1016/j.cmi.2019.10.023	https://doi.org/10.1016/j.cmi.2019.10.023	NOUN
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dti-2469	313	24	https://www.ncbi.nlm.nih.gov/pubmed/16845079	https://www.ncbi.nlm.nih.gov/pubmed/16845079	NUM
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dti-2469	314	10	https://doi.org/10.1093/bioinformatics/btp002	https://doi.org/10.1093/bioinformatics/btp002	PROPN
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dti-2469	314	18	https://doi.org/10.1093/bioinformatics/18.suppl_1.s225	https://doi.org/10.1093/bioinformatics/18.suppl_1.s225	NUM
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dti-2469	314	21	https://www.ncbi.nlm.nih.gov/pubmed/27924014	https://www.ncbi.nlm.nih.gov/pubmed/27924014	PRON
dti-2469	315	1	https://doi.org/10.12688/f1000research.4492.2	https://doi.org/10.12688/f1000research.4492.2	PROPN
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dti-2469	318	6	-	-	SYM
dti-2469	318	7	3928	3928	NUM
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dti-2469	320	2	-	-	PUNCT
dti-2469	320	3	162	162	NUM
dti-2469	320	4	.	.	PUNCT
dti-2469	321	1	crossref	crossref	PROPN
dti-2469	321	2	pubmed	pubmed	PROPN
dti-2469	321	3	36	36	NUM
dti-2469	321	4	.	.	PUNCT
dti-2469	322	1	nesbitt	nesbitt	PROPN
dti-2469	322	2	nm	nm	PROPN
dti-2469	322	3	,	,	PUNCT
dti-2469	322	4	arora	arora	PROPN
dti-2469	322	5	dp	dp	PROPN
dti-2469	322	6	,	,	PUNCT
dti-2469	322	7	johnson	johnson	PROPN
dti-2469	322	8	ra	ra	PROPN
dti-2469	322	9	,	,	PUNCT
dti-2469	322	10	boon	boon	PROPN
dti-2469	322	11	em	em	PRON
dti-2469	322	12	.	.	PUNCT
dti-2469	323	1	modification	modification	NOUN
dti-2469	323	2	of	of	ADP
dti-2469	323	3	a	a	DET
dti-2469	323	4	bi	bi	ADJ
dti-2469	323	5	-	-	ADJ
dti-2469	323	6	functional	functional	ADJ
dti-2469	323	7	diguanylate	diguanylate	ADJ
dti-2469	323	8	cyclase	cyclase	NOUN
dti-2469	323	9	-	-	PUNCT
dti-2469	323	10	phosphodiesterase	phosphodiesterase	NOUN
dti-2469	323	11	to	to	PART
dti-2469	323	12	efficiently	efficiently	ADV
dti-2469	323	13	produce	produce	VERB
dti-2469	323	14	cyclic	cyclic	ADJ
dti-2469	323	15	diguanylate	diguanylate	ADJ
dti-2469	323	16	monophosphate	monophosphate	NOUN
dti-2469	323	17	.	.	PUNCT
dti-2469	324	1	biotechnol	biotechnol	PROPN
dti-2469	324	2	rep	rep	PROPN
dti-2469	324	3	(	(	PUNCT
dti-2469	324	4	amst	amst	PROPN
dti-2469	324	5	)	)	PUNCT
dti-2469	324	6	.	.	PUNCT
dti-2469	325	1	2015;7:30	2015;7:30	NOUN
dti-2469	325	2	-	-	PUNCT
dti-2469	325	3	37	37	NUM
dti-2469	325	4	.	.	PUNCT
dti-2469	326	1	crossref	crossref	PROPN
dti-2469	326	2	pubmed	pubmed	PROPN
dti-2469	326	3	37	37	NUM
dti-2469	326	4	.	.	PUNCT
dti-2469	327	1	phippen	phippen	PROPN
dti-2469	327	2	cw	cw	PROPN
dti-2469	327	3	,	,	PUNCT
dti-2469	327	4	mikolajek	mikolajek	NOUN
dti-2469	327	5	h	h	NOUN
dti-2469	327	6	,	,	PUNCT
dti-2469	327	7	schlaefli	schlaefli	PROPN
dti-2469	327	8	hg	hg	PROPN
dti-2469	327	9	,	,	PUNCT
dti-2469	327	10	keevil	keevil	PROPN
dti-2469	327	11	cw	cw	NOUN
dti-2469	327	12	,	,	PUNCT
dti-2469	327	13	webb	webb	PROPN
dti-2469	327	14	js	js	PROPN
dti-2469	327	15	,	,	PUNCT
dti-2469	327	16	tews	tew	NOUN
dti-2469	327	17	i.	i.	NOUN
dti-2469	327	18	formation	formation	NOUN
dti-2469	327	19	and	and	CCONJ
dti-2469	327	20	dimerization	dimerization	NOUN
dti-2469	327	21	of	of	ADP
dti-2469	327	22	the	the	DET
dti-2469	327	23	phosphodiesterase	phosphodiesterase	NOUN
dti-2469	327	24	active	active	ADJ
dti-2469	327	25	site	site	NOUN
dti-2469	327	26	of	of	ADP
dti-2469	327	27	the	the	DET
dti-2469	327	28	pseudomonas	pseudomonas	PROPN
dti-2469	327	29	aeruginosa	aeruginosa	PROPN
dti-2469	327	30	mora	mora	PROPN
dti-2469	327	31	,	,	PUNCT
dti-2469	327	32	a	a	DET
dti-2469	327	33	bi	bi	ADJ
dti-2469	327	34	functional	functional	ADJ
dti-2469	327	35	c	c	NOUN
dti-2469	327	36	-	-	PUNCT
dti-2469	327	37	di	di	NOUN
dti-2469	327	38	-	-	PUNCT
dti-2469	327	39	gmp	gmp	PROPN
dti-2469	327	40	regulator	regulator	NOUN
dti-2469	327	41	.	.	PUNCT
dti-2469	328	1	febs	febs	PROPN
dti-2469	328	2	lett	lett	PROPN
dti-2469	328	3	.	.	PUNCT
dti-2469	329	1	2014;588(24):46314636	2014;588(24):46314636	NUM
dti-2469	329	2	.	.	PUNCT
dti-2469	330	1	crossref	crossref	PROPN
dti-2469	330	2	pubmed	pubmed	PROPN
dti-2469	330	3	38	38	NUM
dti-2469	330	4	.	.	PUNCT
dti-2469	331	1	fujita	fujita	PROPN
dti-2469	331	2	m	m	PROPN
dti-2469	331	3	,	,	PUNCT
dti-2469	331	4	losick	losick	PROPN
dti-2469	331	5	r.	r.	PROPN
dti-2469	331	6	the	the	DET
dti-2469	331	7	master	master	NOUN
dti-2469	331	8	regulator	regulator	NOUN
dti-2469	331	9	for	for	ADP
dti-2469	331	10	entry	entry	NOUN
dti-2469	331	11	into	into	ADP
dti-2469	331	12	sporulation	sporulation	NOUN
dti-2469	331	13	in	in	ADP
dti-2469	331	14	bacillus	bacillus	NOUN
dti-2469	331	15	subtilis	subtili	NOUN
dti-2469	331	16	becomes	become	VERB
dti-2469	331	17	a	a	DET
dti-2469	331	18	cell	cell	NOUN
dti-2469	331	19	-	-	PUNCT
dti-2469	331	20	specific	specific	ADJ
dti-2469	331	21	transcription	transcription	NOUN
dti-2469	331	22	factor	factor	NOUN
dti-2469	331	23	after	after	ADP
dti-2469	331	24	asymmetric	asymmetric	ADJ
dti-2469	331	25	division	division	NOUN
dti-2469	331	26	.	.	PUNCT
dti-2469	332	1	genes	gene	NOUN
dti-2469	332	2	dev	dev	PROPN
dti-2469	332	3	.	.	PUNCT
dti-2469	333	1	2003;17(9):11661174	2003;17(9):11661174	NUM
dti-2469	333	2	.	.	PUNCT
dti-2469	334	1	crossref	crossref	PROPN
dti-2469	334	2	pubmed	pubmed	PROPN
dti-2469	334	3	39	39	NUM
dti-2469	334	4	.	.	PUNCT
dti-2469	335	1	sivaraman	sivaraman	PROPN
dti-2469	335	2	j	j	PROPN
dti-2469	335	3	,	,	PUNCT
dti-2469	335	4	li	li	PROPN
dti-2469	335	5	y	y	PROPN
dti-2469	335	6	,	,	PUNCT
dti-2469	335	7	larocque	larocque	ADJ
dti-2469	335	8	r	r	NOUN
dti-2469	335	9	,	,	PUNCT
dti-2469	335	10	schrag	schrag	PROPN
dti-2469	335	11	jd	jd	PROPN
dti-2469	335	12	,	,	PUNCT
dti-2469	335	13	cygler	cygler	NOUN
dti-2469	335	14	m	m	PROPN
dti-2469	335	15	,	,	PUNCT
dti-2469	335	16	matte	matte	NOUN
dti-2469	335	17	a.	a.	NOUN
dti-2469	335	18	crystal	crystal	NOUN
dti-2469	335	19	structure	structure	NOUN
dti-2469	335	20	of	of	ADP
dti-2469	335	21	histidinol	histidinol	ADJ
dti-2469	335	22	phosphate	phosphate	NOUN
dti-2469	335	23	aminotransferase	aminotransferase	NOUN
dti-2469	335	24	(	(	PUNCT
dti-2469	335	25	hisc	hisc	PROPN
dti-2469	335	26	)	)	PUNCT
dti-2469	335	27	from	from	ADP
dti-2469	335	28	escherichia	escherichia	NOUN
dti-2469	335	29	coli	coli	NOUN
dti-2469	335	30	,	,	PUNCT
dti-2469	335	31	and	and	CCONJ
dti-2469	335	32	its	its	PRON
dti-2469	335	33	covalent	covalent	NOUN
dti-2469	335	34	complex	complex	NOUN
dti-2469	335	35	with	with	ADP
dti-2469	335	36	pyridoxal-5′-phosphate	pyridoxal-5′-phosphate	ADJ
dti-2469	335	37	and	and	CCONJ
dti-2469	335	38	l	l	ADJ
dti-2469	335	39	-	-	ADJ
dti-2469	335	40	histidinol	histidinol	ADJ
dti-2469	335	41	phosphate	phosphate	NOUN
dti-2469	335	42	.	.	PUNCT
dti-2469	336	1	j	j	PROPN
dti-2469	336	2	mol	mol	ADP
dti-2469	336	3	biol	biol	PROPN
dti-2469	336	4	.	.	PUNCT
dti-2469	337	1	2001;311(4):761	2001;311(4):761	NUM
dti-2469	337	2	-	-	SYM
dti-2469	337	3	776	776	NUM
dti-2469	337	4	.	.	PUNCT
dti-2469	338	1	crossref	crossref	PROPN
dti-2469	338	2	pubmed	pubmed	PROPN
dti-2469	338	3	40	40	NUM
dti-2469	338	4	.	.	PUNCT
dti-2469	339	1	de	de	PROPN
dti-2469	339	2	oliveira	oliveira	PROPN
dti-2469	339	3	md	md	PROPN
dti-2469	339	4	,	,	PUNCT
dti-2469	339	5	araújo	araújo	PROPN
dti-2469	339	6	jo	jo	PROPN
dti-2469	339	7	,	,	PUNCT
dti-2469	339	8	galúcio	galúcio	PROPN
dti-2469	339	9	jmp	jmp	PROPN
dti-2469	339	10	,	,	PUNCT
dti-2469	339	11	santana	santana	PROPN
dti-2469	339	12	k	k	PROPN
dti-2469	339	13	,	,	PUNCT
dti-2469	339	14	lima	lima	PROPN
dti-2469	339	15	ah	ah	INTJ
dti-2469	339	16	.	.	PUNCT
dti-2469	340	1	targeting	target	VERB
dti-2469	340	2	shikimate	shikimate	NOUN
dti-2469	340	3	pathway	pathway	NOUN
dti-2469	340	4	:	:	PUNCT
dti-2469	340	5	in	in	ADP
dti-2469	340	6	silico	silico	NOUN
dti-2469	340	7	analysis	analysis	NOUN
dti-2469	340	8	of	of	ADP
dti-2469	340	9	phosphoenolpyruvate	phosphoenolpyruvate	ADJ
dti-2469	340	10	derivatives	derivative	NOUN
dti-2469	340	11	as	as	ADP
dti-2469	340	12	inhibitors	inhibitor	NOUN
dti-2469	340	13	of	of	ADP
dti-2469	340	14	epsp	epsp	ADJ
dti-2469	340	15	synthase	synthase	NOUN
dti-2469	340	16	and	and	CCONJ
dti-2469	340	17	dahp	dahp	NOUN
dti-2469	340	18	synthase	synthase	NOUN
dti-2469	340	19	.	.	PUNCT
dti-2469	341	1	j	j	PROPN
dti-2469	341	2	mol	mol	ADP
dti-2469	341	3	graph	graph	NOUN
dti-2469	341	4	model	model	NOUN
dti-2469	341	5	.	.	PUNCT
dti-2469	342	1	2020;101:107735	2020;101:107735	X
dti-2469	342	2	.	.	PUNCT
dti-2469	343	1	crossref	crossref	PROPN
dti-2469	343	2	pubmed	pubmed	PROPN
dti-2469	343	3	41	41	NUM
dti-2469	343	4	.	.	PUNCT
dti-2469	344	1	tripathi	tripathi	PROPN
dti-2469	344	2	p	p	PROPN
dti-2469	344	3	,	,	PUNCT
dti-2469	344	4	tripathi	tripathi	PROPN
dti-2469	344	5	v.	v.	ADP
dti-2469	344	6	determination	determination	NOUN
dti-2469	344	7	of	of	ADP
dti-2469	344	8	murg	murg	PROPN
dti-2469	344	9	transferase	transferase	NOUN
dti-2469	344	10	as	as	ADP
dti-2469	344	11	a	a	DET
dti-2469	344	12	potential	potential	ADJ
dti-2469	344	13	drug	drug	NOUN
dti-2469	344	14	target	target	NOUN
dti-2469	344	15	in	in	ADP
dti-2469	344	16	neisseria	neisseria	NOUN
dti-2469	344	17	meningitides	meningitide	NOUN
dti-2469	344	18	by	by	ADP
dti-2469	344	19	spectral	spectral	ADJ
dti-2469	344	20	graph	graph	NOUN
dti-2469	344	21	theory	theory	NOUN
dti-2469	344	22	approach	approach	NOUN
dti-2469	344	23	.	.	PUNCT
dti-2469	345	1	in	in	ADP
dti-2469	345	2	:	:	PUNCT
dti-2469	345	3	kesari	kesari	PROPN
dti-2469	345	4	kk	kk	PROPN
dti-2469	345	5	.	.	PROPN
dti-2469	345	6	perspectives	perspective	NOUN
dti-2469	345	7	in	in	ADP
dti-2469	345	8	environmental	environmental	ADJ
dti-2469	345	9	toxicology	toxicology	NOUN
dti-2469	345	10	2017	2017	NUM
dti-2469	345	11	;	;	PUNCT
dti-2469	345	12	147	147	NUM
dti-2469	345	13	-	-	SYM
dti-2469	345	14	160	160	NUM
dti-2469	345	15	.	.	PUNCT
dti-2469	346	1	crossref	crossref	PROPN
dti-2469	346	2	42	42	NUM
dti-2469	346	3	.	.	PUNCT
dti-2469	347	1	amera	amera	PROPN
dti-2469	347	2	gm	gm	PROPN
dti-2469	347	3	,	,	PUNCT
dti-2469	347	4	khan	khan	PROPN
dti-2469	347	5	rj	rj	PROPN
dti-2469	347	6	,	,	PUNCT
dti-2469	347	7	pathak	pathak	PROPN
dti-2469	347	8	a	a	PROPN
dti-2469	347	9	,	,	PUNCT
dti-2469	347	10	jha	jha	PROPN
dti-2469	347	11	rk	rk	PROPN
dti-2469	347	12	,	,	PUNCT
dti-2469	347	13	muthukumaran	muthukumaran	VERB
dti-2469	347	14	j	j	PROPN
dti-2469	347	15	,	,	PUNCT
dti-2469	347	16	singh	singh	PROPN
dti-2469	347	17	ak	ak	PROPN
dti-2469	347	18	.	.	PROPN
dti-2469	347	19	screening	screen	VERB
dti-2469	347	20	of	of	ADP
dti-2469	347	21	promising	promise	VERB
dti-2469	347	22	molecules	molecule	NOUN
dti-2469	347	23	against	against	ADP
dti-2469	347	24	murg	murg	PROPN
dti-2469	347	25	as	as	ADP
dti-2469	347	26	drug	drug	NOUN
dti-2469	347	27	target	target	NOUN
dti-2469	347	28	in	in	ADP
dti-2469	347	29	multi	multi	ADJ
dti-2469	347	30	-	-	ADJ
dti-2469	347	31	drug	drug	NOUN
dti-2469	347	32	-	-	PUNCT
dti-2469	347	33	resistant	resistant	ADJ
dti-2469	347	34	-	-	PUNCT
dti-2469	347	35	acinetobacter	acinetobacter	NOUN
dti-2469	347	36	baumannii	baumannii	ADJ
dti-2469	347	37	–	–	PUNCT
dti-2469	347	38	insights	insight	NOUN
dti-2469	347	39	from	from	ADP
dti-2469	347	40	comparative	comparative	ADJ
dti-2469	347	41	protein	protein	NOUN
dti-2469	347	42	modeling	modeling	NOUN
dti-2469	347	43	,	,	PUNCT
dti-2469	347	44	molecular	molecular	ADJ
dti-2469	347	45	docking	docking	NOUN
dti-2469	347	46	and	and	CCONJ
dti-2469	347	47	molecular	molecular	ADJ
dti-2469	347	48	dynamics	dynamic	NOUN
dti-2469	347	49	simulation	simulation	NOUN
dti-2469	347	50	.	.	PUNCT
dti-2469	348	1	j	j	PROPN
dti-2469	348	2	biomol	biomol	PROPN
dti-2469	348	3	struct	struct	NOUN
dti-2469	348	4	dyn	dyn	NOUN
dti-2469	348	5	.	.	PUNCT
dti-2469	349	1	2020;38(17):5230	2020;38(17):5230	NUM
dti-2469	349	2	-	-	SYM
dti-2469	349	3	5252	5252	NUM
dti-2469	349	4	.	.	PUNCT
dti-2469	350	1	crossref	crossref	PROPN
dti-2469	350	2	pubmed	pubmed	PROPN
dti-2469	350	3	43	43	NUM
dti-2469	350	4	.	.	PUNCT
dti-2469	351	1	konyariková	konyariková	PROPN
dti-2469	352	1	z	z	X
dti-2469	352	2	,	,	PUNCT
dti-2469	352	3	savková	savková	PROPN
dti-2469	352	4	k	k	PROPN
dti-2469	352	5	,	,	PUNCT
dti-2469	352	6	kozmon	kozmon	PROPN
dti-2469	352	7	s	s	PROPN
dti-2469	352	8	,	,	PUNCT
dti-2469	352	9	mikušová	mikušová	PROPN
dti-2469	352	10	k.	k.	PROPN
dti-2469	352	11	biosynthesis	biosynthesis	PROPN
dti-2469	352	12	of	of	ADP
dti-2469	352	13	galactan	galactan	ADJ
dti-2469	352	14	in	in	ADP
dti-2469	352	15	mycobacterium	mycobacterium	NOUN
dti-2469	352	16	tuberculosis	tuberculosis	NOUN
dti-2469	352	17	as	as	ADP
dti-2469	352	18	a	a	DET
dti-2469	352	19	viable	viable	ADJ
dti-2469	352	20	tb	tb	ADP
dti-2469	352	21	drug	drug	NOUN
dti-2469	352	22	target	target	NOUN
dti-2469	352	23	?	?	PUNCT
dti-2469	353	1	antibiotics	antibiotic	NOUN
dti-2469	353	2	(	(	PUNCT
dti-2469	353	3	basel	basel	PROPN
dti-2469	353	4	)	)	PUNCT
dti-2469	353	5	.	.	PUNCT
dti-2469	354	1	2020;9(1):20	2020;9(1):20	X
dti-2469	354	2	.	.	PUNCT
dti-2469	355	1	crossref	crossref	PROPN
dti-2469	355	2	pubmed	pubmed	PROPN
dti-2469	355	3	44	44	NUM
dti-2469	355	4	.	.	PUNCT
dti-2469	356	1	rioseras	rioseras	PROPN
dti-2469	356	2	b	b	PROPN
dti-2469	356	3	,	,	PUNCT
dti-2469	356	4	yagüe	yagüe	NOUN
dti-2469	356	5	p	p	NOUN
dti-2469	356	6	,	,	PUNCT
dti-2469	356	7	lópez	lópez	NOUN
dti-2469	356	8	-	-	PUNCT
dti-2469	356	9	garcía	garcía	PROPN
dti-2469	356	10	mt	mt	PROPN
dti-2469	356	11	,	,	PUNCT
dti-2469	356	12	et	et	PROPN
dti-2469	356	13	al	al	PROPN
dti-2469	356	14	.	.	PUNCT
dti-2469	356	15	characterization	characterization	NOUN
dti-2469	356	16	of	of	ADP
dti-2469	356	17	sco4439	sco4439	NOUN
dti-2469	356	18	,	,	PUNCT
dti-2469	356	19	a	a	DET
dti-2469	356	20	d	d	NOUN
dti-2469	356	21	-	-	PUNCT
dti-2469	356	22	alanyl	alanyl	VERB
dti-2469	356	23	-	-	PUNCT
dti-2469	356	24	d	d	NOUN
dti-2469	356	25	-	-	PUNCT
dti-2469	356	26	alanine	alanine	NOUN
dti-2469	356	27	carboxypeptidase	carboxypeptidase	NOUN
dti-2469	356	28	involved	involve	VERB
dti-2469	356	29	in	in	ADP
dti-2469	356	30	spore	spore	ADJ
dti-2469	356	31	cell	cell	NOUN
dti-2469	356	32	wall	wall	NOUN
dti-2469	356	33	maturation	maturation	PROPN
dti-2469	356	34	,	,	PUNCT
dti-2469	356	35	resistance	resistance	NOUN
dti-2469	356	36	,	,	PUNCT
dti-2469	356	37	and	and	CCONJ
dti-2469	356	38	germination	germination	NOUN
dti-2469	356	39	in	in	ADP
dti-2469	356	40	streptomyces	streptomyce	NOUN
dti-2469	356	41	coelicolor	coelicolor	NOUN
dti-2469	356	42	.	.	PUNCT
dti-2469	357	1	sci	sci	PROPN
dti-2469	357	2	rep	rep	PROPN
dti-2469	357	3	.	.	PROPN
dti-2469	357	4	2016;6(1):21659	2016;6(1):21659	NUM
dti-2469	357	5	.	.	PUNCT
dti-2469	357	6	crossref	crossref	PROPN
dti-2469	357	7	pubmed	pubmed	PROPN
dti-2469	357	8	45	45	NUM
dti-2469	357	9	.	.	PUNCT
dti-2469	358	1	tamayo	tamayo	PROPN
dti-2469	358	2	r.	r.	PROPN
dti-2469	358	3	cyclic	cyclic	PROPN
dti-2469	358	4	diguanylate	diguanylate	ADJ
dti-2469	358	5	riboswitches	riboswitche	NOUN
dti-2469	358	6	control	control	VERB
dti-2469	358	7	bacterial	bacterial	ADJ
dti-2469	358	8	pathogenesis	pathogenesis	NOUN
dti-2469	358	9	mechanisms	mechanism	NOUN
dti-2469	358	10	.	.	PUNCT
dti-2469	359	1	plos	plos	PROPN
dti-2469	359	2	pathog	pathog	PROPN
dti-2469	359	3	.	.	PUNCT
dti-2469	360	1	2019;15(2):e1007529	2019;15(2):e1007529	X
dti-2469	360	2	.	.	PUNCT
dti-2469	361	1	crossref	crossref	PROPN
dti-2469	361	2	pubmed	pubmed	PROPN
dti-2469	361	3	https://doi.org/10.1042/bj20051851	https://doi.org/10.1042/bj20051851	PROPN
dti-2469	361	4	https://www.ncbi.nlm.nih.gov/pubmed/16466344	https://www.ncbi.nlm.nih.gov/pubmed/16466344	PROPN
dti-2469	361	5	https://doi.org/10.1016/j.btre.2015.04.008	https://doi.org/10.1016/j.btre.2015.04.008	PROPN
dti-2469	361	6	https://www.ncbi.nlm.nih.gov/pubmed/28626712	https://www.ncbi.nlm.nih.gov/pubmed/28626712	NOUN
dti-2469	361	7	https://doi.org/10.1016/j.febslet.2014.11.002	https://doi.org/10.1016/j.febslet.2014.11.002	NOUN
dti-2469	361	8	https://www.ncbi.nlm.nih.gov/pubmed/25447517	https://www.ncbi.nlm.nih.gov/pubmed/25447517	PROPN
dti-2469	361	9	https://doi.org/10.1101/gad.1078303	https://doi.org/10.1101/gad.1078303	PROPN
dti-2469	361	10	https://www.ncbi.nlm.nih.gov/pubmed/12730135	https://www.ncbi.nlm.nih.gov/pubmed/12730135	NUM
dti-2469	361	11	https://doi.org/10.1006/jmbi.2001.4882	https://doi.org/10.1006/jmbi.2001.4882	PROPN
dti-2469	361	12	https://www.ncbi.nlm.nih.gov/pubmed/11518529	https://www.ncbi.nlm.nih.gov/pubmed/11518529	ADP
dti-2469	361	13	https://doi.org/10.1016/j.jmgm.2020.107735	https://doi.org/10.1016/j.jmgm.2020.107735	PROPN
dti-2469	361	14	https://www.ncbi.nlm.nih.gov/pubmed/32947107	https://www.ncbi.nlm.nih.gov/pubmed/32947107	ADP
dti-2469	361	15	https://doi.org/10.1007/978-3-319-46248-6_7	https://doi.org/10.1007/978-3-319-46248-6_7	X
dti-2469	362	1	https://doi.org/10.1080/07391102.2019.1700167	https://doi.org/10.1080/07391102.2019.1700167	PROPN
dti-2469	362	2	https://www.ncbi.nlm.nih.gov/pubmed/31787065	https://www.ncbi.nlm.nih.gov/pubmed/31787065	PROPN
dti-2469	362	3	https://doi.org/10.3390/antibiotics9010020	https://doi.org/10.3390/antibiotics9010020	NOUN
dti-2469	362	4	https://www.ncbi.nlm.nih.gov/pubmed/31935842	https://www.ncbi.nlm.nih.gov/pubmed/31935842	VERB
dti-2469	362	5	https://doi.org/10.1038/srep21659	https://doi.org/10.1038/srep21659	NOUN
dti-2469	362	6	https://www.ncbi.nlm.nih.gov/pubmed/26867711	https://www.ncbi.nlm.nih.gov/pubmed/26867711	NOUN
dti-2469	362	7	https://doi.org/10.1371/journal.ppat.1007529	https://doi.org/10.1371/journal.ppat.1007529	ADV
dti-2469	362	8	https://www.ncbi.nlm.nih.gov/pubmed/30730989	https://www.ncbi.nlm.nih.gov/pubmed/30730989	PROPN