id	sid	tid	token	lemma	pos
dti-3271	1	1	dti	dti	PROPN
dti-3271	1	2	drug	drug	PROPN
dti-3271	1	3	target	target	NOUN
dti-3271	1	4	insights	insight	NOUN
dti-3271	1	5	2025	2025	NUM
dti-3271	1	6	;	;	PUNCT
dti-3271	1	7	19	19	NUM
dti-3271	1	8	:	:	SYM
dti-3271	1	9	11	11	NUM
dti-3271	1	10	-	-	SYM
dti-3271	1	11	17	17	NUM
dti-3271	1	12	issn	issn	PROPN
dti-3271	1	13	1177	1177	NUM
dti-3271	1	14	-	-	SYM
dti-3271	1	15	3928	3928	NUM
dti-3271	1	16	|	|	ADV
dti-3271	1	17	doi	doi	NOUN
dti-3271	1	18	:	:	PUNCT
dti-3271	1	19	10.33393	10.33393	NUM
dti-3271	1	20	/	/	SYM
dti-3271	1	21	dti.2025.3271	dti.2025.3271	PROPN
dti-3271	1	22	original	original	ADJ
dti-3271	1	23	research	research	NOUN
dti-3271	1	24	article	article	NOUN
dti-3271	1	25	drug	drug	NOUN
dti-3271	1	26	target	target	NOUN
dti-3271	1	27	insights	insight	NOUN
dti-3271	1	28	issn	issn	VERB
dti-3271	1	29	1177	1177	NUM
dti-3271	1	30	-	-	SYM
dti-3271	1	31	3928	3928	NUM
dti-3271	1	32	www.aboutscience.eu/dti	www.aboutscience.eu/dti	NOUN
dti-3271	1	33	©	©	PROPN
dti-3271	1	34	2025	2025	NUM
dti-3271	1	35	the	the	DET
dti-3271	1	36	authors	author	NOUN
dti-3271	1	37	.	.	PUNCT
dti-3271	2	1	this	this	DET
dti-3271	2	2	article	article	NOUN
dti-3271	2	3	is	be	AUX
dti-3271	2	4	published	publish	VERB
dti-3271	2	5	by	by	ADP
dti-3271	2	6	aboutscience	aboutscience	NOUN
dti-3271	2	7	and	and	CCONJ
dti-3271	2	8	licensed	license	VERB
dti-3271	2	9	under	under	ADP
dti-3271	2	10	creative	creative	ADJ
dti-3271	2	11	commons	common	NOUN
dti-3271	2	12	attribution	attribution	NOUN
dti-3271	2	13	-	-	PUNCT
dti-3271	2	14	noncommercial	noncommercial	ADJ
dti-3271	2	15	4.0	4.0	NUM
dti-3271	2	16	international	international	NOUN
dti-3271	2	17	(	(	PUNCT
dti-3271	2	18	cc	cc	NOUN
dti-3271	2	19	by	by	ADP
dti-3271	2	20	-	-	PUNCT
dti-3271	2	21	nc	nc	PROPN
dti-3271	2	22	4.0	4.0	NUM
dti-3271	2	23	)	)	PUNCT
dti-3271	2	24	.	.	PUNCT
dti-3271	3	1	commercial	commercial	ADJ
dti-3271	3	2	use	use	NOUN
dti-3271	3	3	is	be	AUX
dti-3271	3	4	not	not	PART
dti-3271	3	5	permitted	permit	VERB
dti-3271	3	6	and	and	CCONJ
dti-3271	3	7	is	be	AUX
dti-3271	3	8	subject	subject	ADJ
dti-3271	3	9	to	to	ADP
dti-3271	3	10	publisher	publisher	NOUN
dti-3271	3	11	’s	’s	PART
dti-3271	3	12	permissions	permission	NOUN
dti-3271	3	13	.	.	PUNCT
dti-3271	4	1	full	full	ADJ
dti-3271	4	2	information	information	NOUN
dti-3271	4	3	is	be	AUX
dti-3271	4	4	available	available	ADJ
dti-3271	4	5	at	at	ADP
dti-3271	4	6	www.aboutscience.eu	www.aboutscience.eu	NOUN
dti-3271	4	7	exploring	explore	VERB
dti-3271	4	8	the	the	DET
dti-3271	4	9	in	in	NOUN
dti-3271	4	10	vitro	vitro	X
dti-3271	4	11	anti	anti	ADJ
dti-3271	4	12	-	-	ADJ
dti-3271	4	13	diabetic	diabetic	ADJ
dti-3271	4	14	potential	potential	NOUN
dti-3271	4	15	and	and	CCONJ
dti-3271	4	16	in	in	ADP
dti-3271	4	17	silico	silico	NOUN
dti-3271	4	18	studies	study	NOUN
dti-3271	4	19	of	of	ADP
dti-3271	4	20	2	2	NUM
dti-3271	4	21	,	,	PUNCT
dti-3271	4	22	3	3	NUM
dti-3271	4	23	and	and	CCONJ
dti-3271	4	24	2	2	NUM
dti-3271	4	25	,	,	PUNCT
dti-3271	4	26	6	6	NUM
dti-3271	4	27	-	-	PUNCT
dti-3271	4	28	dichloroindolinone	dichloroindolinone	NOUN
dti-3271	4	29	abdur	abdur	PROPN
dti-3271	4	30	rauf	rauf	PROPN
dti-3271	4	31	1	1	NUM
dti-3271	4	32	,	,	PUNCT
dti-3271	4	33	waqas	waqas	ADJ
dti-3271	4	34	alam	alam	PROPN
dti-3271	4	35	1	1	NUM
dti-3271	4	36	,	,	PUNCT
dti-3271	4	37	momin	momin	NOUN
dti-3271	4	38	khan2	khan2	PROPN
dti-3271	4	39	,	,	PUNCT
dti-3271	4	40	hany	hany	PROPN
dti-3271	4	41	w.	w.	PROPN
dti-3271	4	42	darwish3	darwish3	PROPN
dti-3271	4	43	,	,	PUNCT
dti-3271	4	44	maria	maria	PROPN
dti-3271	4	45	daglia	daglia	PROPN
dti-3271	4	46	4	4	NUM
dti-3271	4	47	,	,	PUNCT
dti-3271	4	48	ahmed	ahmed	PROPN
dti-3271	4	49	a.	a.	PROPN
dti-3271	4	50	elhenawy	elhenawy	PROPN
dti-3271	4	51	5	5	NUM
dti-3271	4	52	,	,	PUNCT
dti-3271	4	53	haroon	haroon	PROPN
dti-3271	4	54	khan	khan	PROPN
dti-3271	4	55	1,6	1,6	NUM
dti-3271	4	56	1department	1department	NUM
dti-3271	4	57	of	of	ADP
dti-3271	4	58	pharmacy	pharmacy	NOUN
dti-3271	4	59	,	,	PUNCT
dti-3271	4	60	abdul	abdul	PROPN
dti-3271	4	61	wali	wali	PROPN
dti-3271	4	62	khan	khan	PROPN
dti-3271	4	63	university	university	PROPN
dti-3271	4	64	,	,	PUNCT
dti-3271	4	65	mardan	mardan	PROPN
dti-3271	4	66	pakistan	pakistan	PROPN
dti-3271	4	67	2department	2department	NUM
dti-3271	4	68	of	of	ADP
dti-3271	4	69	chemistry	chemistry	NOUN
dti-3271	4	70	,	,	PUNCT
dti-3271	4	71	abdul	abdul	PROPN
dti-3271	4	72	wali	wali	PROPN
dti-3271	4	73	khan	khan	PROPN
dti-3271	4	74	university	university	PROPN
dti-3271	4	75	,	,	PUNCT
dti-3271	4	76	mardan	mardan	PROPN
dti-3271	4	77	pakistan	pakistan	PROPN
dti-3271	4	78	3department	3department	NUM
dti-3271	4	79	of	of	ADP
dti-3271	4	80	pharmaceutical	pharmaceutical	ADJ
dti-3271	4	81	chemistry	chemistry	NOUN
dti-3271	4	82	,	,	PUNCT
dti-3271	4	83	college	college	NOUN
dti-3271	4	84	of	of	ADP
dti-3271	4	85	pharmacy	pharmacy	NOUN
dti-3271	4	86	,	,	PUNCT
dti-3271	4	87	king	king	PROPN
dti-3271	4	88	saud	saud	PROPN
dti-3271	4	89	university	university	PROPN
dti-3271	4	90	,	,	PUNCT
dti-3271	4	91	riyadh	riyadh	PROPN
dti-3271	4	92	kingdom	kingdom	NOUN
dti-3271	4	93	of	of	ADP
dti-3271	4	94	saudi	saudi	PROPN
dti-3271	4	95	arabia	arabia	PROPN
dti-3271	4	96	4department	4department	NUM
dti-3271	4	97	of	of	ADP
dti-3271	4	98	pharmacy	pharmacy	NOUN
dti-3271	4	99	,	,	PUNCT
dti-3271	4	100	university	university	PROPN
dti-3271	4	101	of	of	ADP
dti-3271	4	102	naples	naples	PROPN
dti-3271	4	103	federico	federico	PROPN
dti-3271	4	104	iiitaly	iiitaly	VERB
dti-3271	4	105	5department	5department	NUM
dti-3271	4	106	of	of	ADP
dti-3271	4	107	chemistry	chemistry	NOUN
dti-3271	4	108	,	,	PUNCT
dti-3271	4	109	faculty	faculty	NOUN
dti-3271	4	110	of	of	ADP
dti-3271	4	111	science	science	NOUN
dti-3271	4	112	,	,	PUNCT
dti-3271	4	113	al	al	PROPN
dti-3271	4	114	-	-	PUNCT
dti-3271	4	115	azhar	azhar	PROPN
dti-3271	4	116	university	university	PROPN
dti-3271	4	117	,	,	PUNCT
dti-3271	4	118	cairo	cairo	PROPN
dti-3271	4	119	egypt	egypt	PROPN
dti-3271	4	120	6department	6department	NUM
dti-3271	4	121	of	of	ADP
dti-3271	4	122	pharmacy	pharmacy	NOUN
dti-3271	4	123	,	,	PUNCT
dti-3271	4	124	korea	korea	PROPN
dti-3271	4	125	university	university	PROPN
dti-3271	4	126	,	,	PUNCT
dti-3271	5	1	sejong	sejong	PROPN
dti-3271	5	2	south	south	PROPN
dti-3271	5	3	korea	korea	PROPN
dti-3271	5	4	abstract	abstract	ADJ
dti-3271	5	5	introduction	introduction	NOUN
dti-3271	5	6	:	:	PUNCT
dti-3271	5	7	adequate	adequate	ADJ
dti-3271	5	8	hyperglycemic	hyperglycemic	ADJ
dti-3271	5	9	control	control	NOUN
dti-3271	5	10	is	be	AUX
dti-3271	5	11	still	still	ADV
dti-3271	5	12	a	a	DET
dti-3271	5	13	huge	huge	ADJ
dti-3271	5	14	challenge	challenge	NOUN
dti-3271	5	15	with	with	ADP
dti-3271	5	16	the	the	DET
dti-3271	5	17	clinically	clinically	ADV
dti-3271	5	18	used	use	VERB
dti-3271	5	19	therapeutics	therapeutic	NOUN
dti-3271	5	20	.	.	PUNCT
dti-3271	6	1	new	new	ADJ
dti-3271	6	2	,	,	PUNCT
dti-3271	6	3	more	more	ADV
dti-3271	6	4	effective	effective	ADJ
dti-3271	6	5	anti	anti	ADJ
dti-3271	6	6	-	-	ADJ
dti-3271	6	7	diabetic	diabetic	ADJ
dti-3271	6	8	agents	agent	NOUN
dti-3271	6	9	are	be	AUX
dti-3271	6	10	on	on	ADP
dti-3271	6	11	the	the	DET
dti-3271	6	12	top	top	ADJ
dti-3271	6	13	list	list	NOUN
dti-3271	6	14	of	of	ADP
dti-3271	6	15	drug	drug	NOUN
dti-3271	6	16	discovery	discovery	NOUN
dti-3271	6	17	projects	project	NOUN
dti-3271	6	18	.	.	PUNCT
dti-3271	7	1	methods	method	NOUN
dti-3271	7	2	:	:	PUNCT
dti-3271	7	3	this	this	DET
dti-3271	7	4	article	article	NOUN
dti-3271	7	5	deals	deal	VERB
dti-3271	7	6	with	with	ADP
dti-3271	7	7	the	the	DET
dti-3271	7	8	in	in	NOUN
dti-3271	7	9	vitro	vitro	X
dti-3271	7	10	anti	anti	ADJ
dti-3271	7	11	-	-	ADJ
dti-3271	7	12	diabetic	diabetic	ADJ
dti-3271	7	13	potential	potential	NOUN
dti-3271	7	14	of	of	ADP
dti-3271	7	15	2	2	NUM
dti-3271	7	16	,	,	PUNCT
dti-3271	7	17	3	3	NUM
dti-3271	7	18	dichloroindolinone	dichloroindolinone	NOUN
dti-3271	7	19	(	(	PUNCT
dti-3271	7	20	c1	c1	PROPN
dti-3271	7	21	)	)	PUNCT
dti-3271	7	22	and	and	CCONJ
dti-3271	7	23	2	2	NUM
dti-3271	7	24	,	,	PUNCT
dti-3271	7	25	6	6	NUM
dti-3271	7	26	-	-	PUNCT
dti-3271	7	27	dichloroindolinone	dichloroindolinone	NOUN
dti-3271	7	28	(	(	PUNCT
dti-3271	7	29	c2	c2	PROPN
dti-3271	7	30	)	)	PUNCT
dti-3271	7	31	on	on	ADP
dti-3271	7	32	α	α	NOUN
dti-3271	7	33	-	-	NOUN
dti-3271	7	34	glucosidase	glucosidase	ADJ
dti-3271	7	35	and	and	CCONJ
dti-3271	7	36	α	α	NOUN
dti-3271	7	37	-	-	NOUN
dti-3271	7	38	amylase	amylase	NOUN
dti-3271	7	39	followed	follow	VERB
dti-3271	7	40	by	by	ADP
dti-3271	7	41	in	in	ADP
dti-3271	7	42	silico	silico	NOUN
dti-3271	7	43	analysis	analysis	NOUN
dti-3271	7	44	.	.	PUNCT
dti-3271	8	1	results	result	NOUN
dti-3271	8	2	:	:	PUNCT
dti-3271	8	3	both	both	DET
dti-3271	8	4	compounds	compound	NOUN
dti-3271	8	5	,	,	PUNCT
dti-3271	8	6	c-1	c-1	NOUN
dti-3271	8	7	and	and	CCONJ
dti-3271	8	8	c-2	c-2	NOUN
dti-3271	8	9	,	,	PUNCT
dti-3271	8	10	caused	cause	VERB
dti-3271	8	11	significant	significant	ADJ
dti-3271	8	12	inhibition	inhibition	NOUN
dti-3271	8	13	of	of	ADP
dti-3271	8	14	α	α	NOUN
dti-3271	8	15	-	-	NOUN
dti-3271	8	16	glucosidase	glucosidase	NOUN
dti-3271	8	17	at	at	ADP
dti-3271	8	18	various	various	ADJ
dti-3271	8	19	test	test	NOUN
dti-3271	8	20	concentrations	concentration	NOUN
dti-3271	8	21	with	with	ADP
dti-3271	8	22	ic50	ic50	PROPN
dti-3271	8	23	of	of	ADP
dti-3271	8	24	35.266	35.266	NUM
dti-3271	8	25	μm	μm	NUM
dti-3271	8	26	and	and	CCONJ
dti-3271	8	27	38	38	NUM
dti-3271	8	28	.	.	PUNCT
dti-3271	8	29	379	379	NUM
dti-3271	8	30	μm	μm	NUM
dti-3271	8	31	,	,	PUNCT
dti-3271	8	32	respectively	respectively	ADV
dti-3271	8	33	.	.	PUNCT
dti-3271	9	1	similarly	similarly	ADV
dti-3271	9	2	,	,	PUNCT
dti-3271	9	3	compounds	compound	VERB
dti-3271	9	4	c-1	c-1	NOUN
dti-3271	9	5	and	and	CCONJ
dti-3271	9	6	c-2	c-2	NOUN
dti-3271	9	7	elicited	elicit	VERB
dti-3271	9	8	significant	significant	ADJ
dti-3271	9	9	anti	anti	ADJ
dti-3271	9	10	-	-	ADJ
dti-3271	9	11	α	α	PRON
dti-3271	9	12	-	-	PUNCT
dti-3271	9	13	amylase	amylase	NOUN
dti-3271	9	14	action	action	NOUN
dti-3271	9	15	with	with	ADP
dti-3271	9	16	ic50	ic50	PROPN
dti-3271	9	17	values	value	NOUN
dti-3271	9	18	of	of	ADP
dti-3271	9	19	42.449	42.449	NUM
dti-3271	9	20	μm	μm	NUM
dti-3271	9	21	and	and	CCONJ
dti-3271	9	22	46.708	46.708	NUM
dti-3271	9	23	μm	μm	NUM
dti-3271	9	24	,	,	PUNCT
dti-3271	9	25	respectively	respectively	ADV
dti-3271	9	26	.	.	PUNCT
dti-3271	10	1	the	the	DET
dti-3271	10	2	molecular	molecular	ADJ
dti-3271	10	3	docking	docking	NOUN
dti-3271	10	4	investigation	investigation	NOUN
dti-3271	10	5	regarding	regard	VERB
dti-3271	10	6	the	the	DET
dti-3271	10	7	α	α	NOUN
dti-3271	10	8	-	-	NOUN
dti-3271	10	9	glucosidase	glucosidase	ADJ
dti-3271	10	10	and	and	CCONJ
dti-3271	10	11	α	α	NOUN
dti-3271	10	12	-	-	PUNCT
dti-3271	10	13	amylase	amylase	NOUN
dti-3271	10	14	binding	bind	VERB
dti-3271	10	15	site	site	NOUN
dti-3271	10	16	was	be	AUX
dti-3271	10	17	implemented	implement	VERB
dti-3271	10	18	to	to	PART
dti-3271	10	19	attain	attain	VERB
dti-3271	10	20	better	well	ADJ
dti-3271	10	21	comprehension	comprehension	NOUN
dti-3271	10	22	with	with	ADP
dti-3271	10	23	respect	respect	NOUN
dti-3271	10	24	to	to	ADP
dti-3271	10	25	the	the	DET
dti-3271	10	26	pattern	pattern	NOUN
dti-3271	10	27	in	in	ADP
dti-3271	10	28	which	which	PRON
dti-3271	10	29	binding	bind	VERB
dti-3271	10	30	mechanics	mechanic	NOUN
dti-3271	10	31	occur	occur	VERB
dti-3271	10	32	between	between	ADP
dti-3271	10	33	the	the	DET
dti-3271	10	34	c1	c1	PROPN
dti-3271	10	35	and	and	CCONJ
dti-3271	10	36	c2	c2	PROPN
dti-3271	10	37	molecules	molecule	NOUN
dti-3271	10	38	and	and	CCONJ
dti-3271	10	39	the	the	DET
dti-3271	10	40	active	active	ADJ
dti-3271	10	41	sites	site	NOUN
dti-3271	10	42	,	,	PUNCT
dti-3271	10	43	which	which	PRON
dti-3271	10	44	illustrated	illustrate	VERB
dti-3271	10	45	a	a	DET
dti-3271	10	46	higher	high	ADJ
dti-3271	10	47	binding	bind	VERB
dti-3271	10	48	efficacy	efficacy	NOUN
dti-3271	10	49	in	in	ADP
dti-3271	10	50	appraisal	appraisal	NOUN
dti-3271	10	51	with	with	ADP
dti-3271	10	52	reference	reference	NOUN
dti-3271	10	53	inhibitor	inhibitor	NOUN
dti-3271	10	54	and	and	CCONJ
dti-3271	10	55	acarbose	acarbose	NOUN
dti-3271	10	56	.	.	PUNCT
dti-3271	11	1	the	the	DET
dti-3271	11	2	interactions	interaction	NOUN
dti-3271	11	3	between	between	ADP
dti-3271	11	4	the	the	DET
dti-3271	11	5	active	active	ADJ
dti-3271	11	6	compounds	compound	NOUN
dti-3271	11	7	c1	c1	PROPN
dti-3271	11	8	and	and	CCONJ
dti-3271	11	9	c2	c2	PROPN
dti-3271	11	10	with	with	ADP
dti-3271	11	11	the	the	DET
dti-3271	11	12	active	active	ADJ
dti-3271	11	13	site	site	NOUN
dti-3271	11	14	residues	residue	NOUN
dti-3271	11	15	were	be	AUX
dti-3271	11	16	mainly	mainly	ADV
dti-3271	11	17	polar	polar	ADJ
dti-3271	11	18	bonds	bond	NOUN
dti-3271	11	19	,	,	PUNCT
dti-3271	11	20	hydrogen	hydrogen	NOUN
dti-3271	11	21	bonding	bonding	NOUN
dti-3271	11	22	,	,	PUNCT
dti-3271	11	23	π−π	π−π	PROPN
dti-3271	11	24	,	,	PUNCT
dti-3271	11	25	and	and	CCONJ
dti-3271	11	26	π−h	π−h	NOUN
dti-3271	11	27	interactions	interaction	NOUN
dti-3271	11	28	,	,	PUNCT
dti-3271	11	29	which	which	PRON
dti-3271	11	30	contributed	contribute	VERB
dti-3271	11	31	to	to	ADP
dti-3271	11	32	a	a	DET
dti-3271	11	33	strong	strong	ADJ
dti-3271	11	34	alignment	alignment	NOUN
dti-3271	11	35	with	with	ADP
dti-3271	11	36	the	the	DET
dti-3271	11	37	enzyme	enzyme	NOUN
dti-3271	11	38	backbone	backbone	NOUN
dti-3271	11	39	.	.	PUNCT
dti-3271	12	1	similarly	similarly	ADV
dti-3271	12	2	,	,	PUNCT
dti-3271	12	3	effective	effective	ADJ
dti-3271	12	4	binding	binding	NOUN
dti-3271	12	5	is	be	AUX
dti-3271	12	6	frequently	frequently	ADV
dti-3271	12	7	indicated	indicate	VERB
dti-3271	12	8	by	by	ADP
dti-3271	12	9	a	a	DET
dti-3271	12	10	strong	strong	ADJ
dti-3271	12	11	and	and	CCONJ
dti-3271	12	12	stable	stable	ADJ
dti-3271	12	13	hydrogen	hydrogen	NOUN
dti-3271	12	14	-	-	PUNCT
dti-3271	12	15	bonding	bonding	NOUN
dti-3271	12	16	pattern	pattern	NOUN
dti-3271	12	17	,	,	PUNCT
dti-3271	12	18	which	which	PRON
dti-3271	12	19	is	be	AUX
dti-3271	12	20	suggested	suggest	VERB
dti-3271	12	21	by	by	ADP
dti-3271	12	22	the	the	DET
dti-3271	12	23	minimal	minimal	ADJ
dti-3271	12	24	fluctuation	fluctuation	NOUN
dti-3271	12	25	in	in	ADP
dti-3271	12	26	mm	mm	NOUN
dti-3271	12	27	-	-	PUNCT
dti-3271	12	28	pbsa	pbsa	NOUN
dti-3271	12	29	values	value	NOUN
dti-3271	12	30	.	.	PUNCT
dti-3271	13	1	conclusion	conclusion	NOUN
dti-3271	13	2	:	:	PUNCT
dti-3271	13	3	in	in	ADP
dti-3271	13	4	short	short	ADJ
dti-3271	13	5	,	,	PUNCT
dti-3271	13	6	this	this	DET
dti-3271	13	7	study	study	NOUN
dti-3271	13	8	will	will	AUX
dti-3271	13	9	contribute	contribute	VERB
dti-3271	13	10	to	to	ADP
dti-3271	13	11	providing	provide	VERB
dti-3271	13	12	these	these	DET
dti-3271	13	13	compounds	compound	NOUN
dti-3271	13	14	with	with	ADP
dti-3271	13	15	an	an	DET
dti-3271	13	16	improved	improved	ADJ
dti-3271	13	17	anti	anti	ADJ
dti-3271	13	18	-	-	ADJ
dti-3271	13	19	diabetic	diabetic	ADJ
dti-3271	13	20	profile	profile	NOUN
dti-3271	13	21	and	and	CCONJ
dti-3271	13	22	decreased	decrease	VERB
dti-3271	13	23	toxicity	toxicity	NOUN
dti-3271	13	24	.	.	PUNCT
dti-3271	14	1	keywords	keyword	NOUN
dti-3271	14	2	:	:	PUNCT
dti-3271	14	3	2	2	NUM
dti-3271	14	4	,	,	PUNCT
dti-3271	14	5	3	3	NUM
dti-3271	14	6	and	and	CCONJ
dti-3271	14	7	2	2	NUM
dti-3271	14	8	,	,	PUNCT
dti-3271	14	9	6	6	NUM
dti-3271	14	10	-	-	PUNCT
dti-3271	14	11	dichloroindolinone	dichloroindolinone	NOUN
dti-3271	14	12	,	,	PUNCT
dti-3271	14	13	α	α	NOUN
dti-3271	14	14	-	-	PUNCT
dti-3271	14	15	glucosidase	glucosidase	ADJ
dti-3271	14	16	/	/	SYM
dti-3271	14	17	α	α	NOUN
dti-3271	14	18	-	-	PUNCT
dti-3271	14	19	amylase	amylase	NOUN
dti-3271	14	20	inhibition	inhibition	NOUN
dti-3271	14	21	,	,	PUNCT
dti-3271	14	22	molecular	molecular	ADJ
dti-3271	14	23	docking	docking	NOUN
dti-3271	14	24	,	,	PUNCT
dti-3271	14	25	molecular	molecular	ADJ
dti-3271	14	26	simulation	simulation	NOUN
dti-3271	14	27	received	receive	VERB
dti-3271	14	28	:	:	PUNCT
dti-3271	14	29	august	august	PROPN
dti-3271	14	30	23	23	NUM
dti-3271	14	31	,	,	PUNCT
dti-3271	14	32	2024	2024	NUM
dti-3271	14	33	accepted	accept	VERB
dti-3271	14	34	:	:	PUNCT
dti-3271	14	35	february	february	NOUN
dti-3271	14	36	4	4	NUM
dti-3271	14	37	,	,	PUNCT
dti-3271	14	38	2025	2025	NUM
dti-3271	14	39	published	publish	VERB
dti-3271	14	40	online	online	ADV
dti-3271	14	41	:	:	PUNCT
dti-3271	14	42	march	march	PROPN
dti-3271	14	43	10	10	NUM
dti-3271	14	44	,	,	PUNCT
dti-3271	14	45	2025	2025	NUM
dti-3271	14	46	corresponding	correspond	VERB
dti-3271	14	47	author	author	NOUN
dti-3271	14	48	:	:	PUNCT
dti-3271	14	49	haroon	haroon	PROPN
dti-3271	14	50	khan	khan	PROPN
dti-3271	14	51	email	email	NOUN
dti-3271	14	52	:	:	PUNCT
dti-3271	14	53	haroonkhan@awkum.edu.pk	haroonkhan@awkum.edu.pk	NOUN
dti-3271	14	54	by	by	ADP
dti-3271	14	55	type	type	NOUN
dti-3271	14	56	ii	ii	PROPN
dti-3271	14	57	dm	dm	PROPN
dti-3271	14	58	(	(	PUNCT
dti-3271	14	59	t2	t2	PROPN
dti-3271	14	60	dm	dm	PROPN
dti-3271	14	61	)	)	PUNCT
dti-3271	14	62	,	,	PUNCT
dti-3271	14	63	which	which	PRON
dti-3271	14	64	is	be	AUX
dti-3271	14	65	described	describe	VERB
dti-3271	14	66	by	by	ADP
dti-3271	14	67	tissue	tissue	NOUN
dti-3271	14	68	inadequate	inadequate	ADJ
dti-3271	14	69	insulin	insulin	NOUN
dti-3271	14	70	or	or	CCONJ
dti-3271	14	71	insulin	insulin	NOUN
dti-3271	14	72	resistance	resistance	NOUN
dti-3271	14	73	synthesis	synthesis	NOUN
dti-3271	14	74	by	by	ADP
dti-3271	14	75	the	the	DET
dti-3271	14	76	pancreatic	pancreatic	ADJ
dti-3271	14	77	β	β	NOUN
dti-3271	14	78	cells	cell	NOUN
dti-3271	14	79	and	and	CCONJ
dti-3271	14	80	an	an	DET
dti-3271	14	81	improper	improper	ADJ
dti-3271	14	82	compensatory	compensatory	ADJ
dti-3271	14	83	insulin	insulin	NOUN
dti-3271	14	84	secretory	secretory	ADJ
dti-3271	14	85	response	response	NOUN
dti-3271	14	86	(	(	PUNCT
dti-3271	14	87	2	2	NUM
dti-3271	14	88	)	)	PUNCT
dti-3271	14	89	.	.	PUNCT
dti-3271	15	1	diabetes	diabetes	NOUN
dti-3271	15	2	is	be	AUX
dti-3271	15	3	the	the	DET
dti-3271	15	4	tenth	tenth	ADV
dti-3271	15	5	most	most	ADV
dti-3271	15	6	common	common	ADJ
dti-3271	15	7	cause	cause	NOUN
dti-3271	15	8	of	of	ADP
dti-3271	15	9	death	death	NOUN
dti-3271	15	10	,	,	PUNCT
dti-3271	15	11	accounting	account	VERB
dti-3271	15	12	for	for	ADP
dti-3271	15	13	over	over	ADP
dti-3271	15	14	a	a	DET
dti-3271	15	15	million	million	NUM
dti-3271	15	16	deaths	death	NOUN
dti-3271	15	17	annually	annually	ADV
dti-3271	15	18	.	.	PUNCT
dti-3271	16	1	by	by	ADP
dti-3271	16	2	2030	2030	NUM
dti-3271	16	3	,	,	PUNCT
dti-3271	16	4	the	the	DET
dti-3271	16	5	number	number	NOUN
dti-3271	16	6	of	of	ADP
dti-3271	16	7	people	people	NOUN
dti-3271	16	8	with	with	ADP
dti-3271	16	9	type	type	NOUN
dti-3271	16	10	2	2	NUM
dti-3271	16	11	diabetes	diabetes	NOUN
dti-3271	16	12	worldwide	worldwide	ADV
dti-3271	16	13	is	be	AUX
dti-3271	16	14	expected	expect	VERB
dti-3271	16	15	to	to	PART
dti-3271	16	16	reach	reach	VERB
dti-3271	16	17	7079	7079	NUM
dti-3271	16	18	per	per	ADP
dti-3271	16	19	100,000	100,000	NUM
dti-3271	16	20	,	,	PUNCT
dti-3271	16	21	indicating	indicate	VERB
dti-3271	16	22	a	a	DET
dti-3271	16	23	persistent	persistent	ADJ
dti-3271	16	24	increase	increase	NOUN
dti-3271	16	25	in	in	ADP
dti-3271	16	26	cases	case	NOUN
dti-3271	16	27	worldwide	worldwide	ADV
dti-3271	16	28	.	.	PUNCT
dti-3271	17	1	concerning	concern	VERB
dti-3271	17	2	evidence	evidence	NOUN
dti-3271	17	3	indicates	indicate	VERB
dti-3271	17	4	that	that	SCONJ
dti-3271	17	5	prevalence	prevalence	NOUN
dti-3271	17	6	is	be	AUX
dti-3271	17	7	on	on	ADP
dti-3271	17	8	the	the	DET
dti-3271	17	9	rise	rise	NOUN
dti-3271	17	10	in	in	ADP
dti-3271	17	11	lower	low	ADJ
dti-3271	17	12	-	-	PUNCT
dti-3271	17	13	income	income	NOUN
dti-3271	17	14	nations	nation	NOUN
dti-3271	17	15	.	.	PUNCT
dti-3271	18	1	there	there	PRON
dti-3271	18	2	is	be	VERB
dti-3271	18	3	a	a	DET
dti-3271	18	4	need	need	NOUN
dti-3271	18	5	for	for	ADP
dti-3271	18	6	immediate	immediate	ADJ
dti-3271	18	7	clinical	clinical	ADJ
dti-3271	18	8	preventative	preventative	NOUN
dti-3271	18	9	and	and	CCONJ
dti-3271	18	10	public	public	ADJ
dti-3271	18	11	health	health	NOUN
dti-3271	18	12	actions	action	NOUN
dti-3271	18	13	.	.	PUNCT
dti-3271	19	1	(	(	PUNCT
dti-3271	19	2	3	3	NUM
dti-3271	19	3	)	)	PUNCT
dti-3271	19	4	.	.	PUNCT
dti-3271	20	1	type	type	NOUN
dti-3271	20	2	2	2	NUM
dti-3271	20	3	diabetes	diabete	NOUN
dti-3271	20	4	,	,	PUNCT
dti-3271	20	5	which	which	PRON
dti-3271	20	6	develops	develop	VERB
dti-3271	20	7	in	in	ADP
dti-3271	20	8	adult	adult	NOUN
dti-3271	20	9	age	age	NOUN
dti-3271	20	10	,	,	PUNCT
dti-3271	20	11	is	be	AUX
dti-3271	20	12	defined	define	VERB
dti-3271	20	13	by	by	ADP
dti-3271	20	14	inadequate	inadequate	ADJ
dti-3271	20	15	insulin	insulin	NOUN
dti-3271	20	16	production	production	NOUN
dti-3271	20	17	,	,	PUNCT
dti-3271	20	18	either	either	CCONJ
dti-3271	20	19	alone	alone	ADJ
dti-3271	20	20	or	or	CCONJ
dti-3271	20	21	in	in	ADP
dti-3271	20	22	combination	combination	NOUN
dti-3271	20	23	with	with	ADP
dti-3271	20	24	insulin	insulin	NOUN
dti-3271	20	25	resistance	resistance	NOUN
dti-3271	20	26	(	(	PUNCT
dti-3271	20	27	4	4	NUM
dti-3271	20	28	)	)	PUNCT
dti-3271	20	29	.	.	PUNCT
dti-3271	21	1	there	there	PRON
dti-3271	21	2	are	be	VERB
dti-3271	21	3	some	some	DET
dti-3271	21	4	key	key	ADJ
dti-3271	21	5	similarities	similarity	NOUN
dti-3271	21	6	between	between	ADP
dti-3271	21	7	heart	heart	NOUN
dti-3271	21	8	disease	disease	NOUN
dti-3271	21	9	[	[	X
dti-3271	21	10	cardiovascular	cardiovascular	ADJ
dti-3271	21	11	disease	disease	NOUN
dti-3271	21	12	(	(	PUNCT
dti-3271	21	13	cvd	cvd	PROPN
dti-3271	21	14	)	)	PUNCT
dti-3271	21	15	]	]	PUNCT
dti-3271	21	16	and	and	CCONJ
dti-3271	21	17	dm	dm	X
dti-3271	21	18	.	.	PUNCT
dti-3271	22	1	one	one	NUM
dti-3271	22	2	significant	significant	ADJ
dti-3271	22	3	and	and	CCONJ
dti-3271	22	4	unique	unique	ADJ
dti-3271	22	5	risk	risk	NOUN
dti-3271	22	6	factor	factor	NOUN
dti-3271	22	7	for	for	ADP
dti-3271	22	8	cvd	cvd	PROPN
dti-3271	22	9	is	be	AUX
dti-3271	22	10	diabetes	diabete	NOUN
dti-3271	22	11	.	.	PUNCT
dti-3271	23	1	the	the	DET
dti-3271	23	2	most	most	ADV
dti-3271	23	3	frequent	frequent	ADJ
dti-3271	23	4	and	and	CCONJ
dti-3271	23	5	expensive	expensive	ADJ
dti-3271	23	6	blood	blood	NOUN
dti-3271	23	7	vessel	vessel	NOUN
dti-3271	23	8	consequence	consequence	NOUN
dti-3271	23	9	of	of	ADP
dti-3271	23	10	diabetes	diabetes	NOUN
dti-3271	23	11	is	be	AUX
dti-3271	23	12	heart	heart	NOUN
dti-3271	23	13	disease	disease	NOUN
dti-3271	23	14	[	[	PUNCT
dti-3271	23	15	coronary	coronary	ADJ
dti-3271	23	16	heart	heart	NOUN
dti-3271	23	17	disease	disease	NOUN
dti-3271	23	18	(	(	PUNCT
dti-3271	23	19	chd	chd	NOUN
dti-3271	23	20	)	)	PUNCT
dti-3271	23	21	]	]	PUNCT
dti-3271	24	1	(	(	PUNCT
dti-3271	24	2	5	5	NUM
dti-3271	24	3	)	)	PUNCT
dti-3271	24	4	.	.	PUNCT
dti-3271	25	1	there	there	PRON
dti-3271	25	2	are	be	VERB
dti-3271	25	3	presently	presently	ADV
dti-3271	25	4	no	no	DET
dti-3271	25	5	effective	effective	ADJ
dti-3271	25	6	medications	medication	NOUN
dti-3271	25	7	to	to	PART
dti-3271	25	8	treat	treat	VERB
dti-3271	25	9	this	this	DET
dti-3271	25	10	health	health	NOUN
dti-3271	25	11	condition	condition	NOUN
dti-3271	25	12	,	,	PUNCT
dti-3271	25	13	and	and	CCONJ
dti-3271	25	14	the	the	DET
dti-3271	25	15	available	available	ADJ
dti-3271	25	16	therapies	therapy	NOUN
dti-3271	25	17	are	be	AUX
dti-3271	25	18	successful	successful	ADJ
dti-3271	25	19	for	for	SCONJ
dti-3271	25	20	some	some	DET
dti-3271	25	21	introduction	introduction	NOUN
dti-3271	25	22	diabetes	diabetes	NOUN
dti-3271	25	23	mellitus	mellitus	NOUN
dti-3271	25	24	(	(	PUNCT
dti-3271	25	25	dm	dm	PROPN
dti-3271	25	26	)	)	PUNCT
dti-3271	25	27	is	be	AUX
dti-3271	25	28	a	a	DET
dti-3271	25	29	prolonged	prolonged	ADJ
dti-3271	25	30	metabolic	metabolic	NOUN
dti-3271	25	31	state	state	NOUN
dti-3271	25	32	that	that	PRON
dti-3271	25	33	can	can	AUX
dti-3271	25	34	result	result	VERB
dti-3271	25	35	from	from	ADP
dti-3271	25	36	reduced	reduce	VERB
dti-3271	25	37	insulin	insulin	NOUN
dti-3271	25	38	synthesis	synthesis	NOUN
dti-3271	25	39	or	or	CCONJ
dti-3271	25	40	decreased	decrease	VERB
dti-3271	25	41	insulin	insulin	NOUN
dti-3271	25	42	’s	’s	PART
dti-3271	25	43	ability	ability	NOUN
dti-3271	25	44	to	to	PART
dti-3271	25	45	facilitate	facilitate	VERB
dti-3271	25	46	the	the	DET
dti-3271	25	47	absorption	absorption	NOUN
dti-3271	25	48	of	of	ADP
dti-3271	25	49	glucose	glucose	NOUN
dti-3271	25	50	.	.	PUNCT
dti-3271	26	1	hyperglycemia	hyperglycemia	NOUN
dti-3271	26	2	or	or	CCONJ
dti-3271	26	3	extremely	extremely	ADV
dti-3271	26	4	high	high	ADJ
dti-3271	26	5	blood	blood	NOUN
dti-3271	26	6	glucose	glucose	NOUN
dti-3271	26	7	,	,	PUNCT
dti-3271	26	8	and	and	CCONJ
dti-3271	26	9	glucose	glucose	NOUN
dti-3271	26	10	intolerance	intolerance	NOUN
dti-3271	26	11	are	be	AUX
dti-3271	26	12	characteristics	characteristic	NOUN
dti-3271	26	13	of	of	ADP
dti-3271	26	14	dm	dm	PROPN
dti-3271	26	15	(	(	PUNCT
dti-3271	26	16	1	1	NUM
dti-3271	26	17	)	)	PUNCT
dti-3271	26	18	.	.	PUNCT
dti-3271	27	1	the	the	DET
dti-3271	27	2	world	world	PROPN
dti-3271	27	3	health	health	PROPN
dti-3271	27	4	organization	organization	NOUN
dti-3271	27	5	(	(	PUNCT
dti-3271	27	6	who	who	PRON
dti-3271	27	7	)	)	PUNCT
dti-3271	27	8	describes	describe	VERB
dti-3271	27	9	dm	dm	PROPN
dti-3271	27	10	as	as	ADP
dti-3271	27	11	a	a	DET
dti-3271	27	12	life	life	NOUN
dti-3271	27	13	-	-	PUNCT
dti-3271	27	14	long	long	ADJ
dti-3271	27	15	metabolic	metabolic	NOUN
dti-3271	27	16	disorder	disorder	NOUN
dti-3271	27	17	marked	mark	VERB
dti-3271	27	18	by	by	ADP
dti-3271	27	19	increased	increase	VERB
dti-3271	27	20	blood	blood	NOUN
dti-3271	27	21	glucose	glucose	NOUN
dti-3271	27	22	levels	level	NOUN
dti-3271	27	23	that	that	PRON
dti-3271	27	24	eventually	eventually	ADV
dti-3271	27	25	cause	cause	VERB
dti-3271	27	26	harm	harm	NOUN
dti-3271	27	27	to	to	ADP
dti-3271	27	28	the	the	DET
dti-3271	27	29	kidneys	kidney	NOUN
dti-3271	27	30	,	,	PUNCT
dti-3271	27	31	eyes	eye	NOUN
dti-3271	27	32	,	,	PUNCT
dti-3271	27	33	nerves	nerve	NOUN
dti-3271	27	34	,	,	PUNCT
dti-3271	27	35	cardiovascular	cardiovascular	ADJ
dti-3271	27	36	system	system	NOUN
dti-3271	27	37	,	,	PUNCT
dti-3271	27	38	and	and	CCONJ
dti-3271	27	39	vascular	vascular	ADJ
dti-3271	27	40	system	system	NOUN
dti-3271	27	41	.	.	PUNCT
dti-3271	28	1	over	over	ADP
dti-3271	28	2	ninety	ninety	NUM
dti-3271	28	3	percent	percent	NOUN
dti-3271	28	4	of	of	ADP
dti-3271	28	5	the	the	DET
dti-3271	28	6	cases	case	NOUN
dti-3271	28	7	of	of	ADP
dti-3271	28	8	dm	dm	PROPN
dti-3271	28	9	are	be	AUX
dti-3271	28	10	caused	cause	VERB
dti-3271	28	11	https://doi.org/10.33393/dti.2025.3271	https://doi.org/10.33393/dti.2025.3271	ADP
dti-3271	28	12	https://creativecommons.org/licenses/by-nc/4.0/legalcode	https://creativecommons.org/licenses/by-nc/4.0/legalcode	NUM
dti-3271	28	13	https://orcid.org/0009-0009-4680-4956	https://orcid.org/0009-0009-4680-4956	NOUN
dti-3271	28	14	https://orcid.org/0009-0009-4680-4956	https://orcid.org/0009-0009-4680-4956	PROPN
dti-3271	28	15	https://orcid.org/0009-0009-4680-4956	https://orcid.org/0009-0009-4680-4956	PROPN
dti-3271	28	16	https://orcid.org/0009-0009-4680-4956	https://orcid.org/0009-0009-4680-4956	PROPN
dti-3271	28	17	https://orcid.org/0009-0009-4680-4956	https://orcid.org/0009-0009-4680-4956	PROPN
dti-3271	28	18	mailto	mailto	PROPN
dti-3271	28	19	:	:	PUNCT
dti-3271	28	20	haroonkhan%40awkum.edu.pk?subject=	haroonkhan%40awkum.edu.pk?subject=	VERB
dti-3271	28	21	anti	anti	ADJ
dti-3271	28	22	-	-	ADJ
dti-3271	28	23	diabetic	diabetic	ADJ
dti-3271	28	24	effects	effect	NOUN
dti-3271	28	25	of	of	ADP
dti-3271	28	26	dichloroindolinone12	dichloroindolinone12	NOUN
dti-3271	28	27	©	©	PROPN
dti-3271	28	28	2025	2025	NUM
dti-3271	28	29	the	the	DET
dti-3271	28	30	authors	author	NOUN
dti-3271	28	31	.	.	PUNCT
dti-3271	29	1	drug	drug	NOUN
dti-3271	29	2	target	target	NOUN
dti-3271	29	3	insights	insight	NOUN
dti-3271	29	4	issn	issn	VERB
dti-3271	29	5	1177	1177	NUM
dti-3271	29	6	-	-	SYM
dti-3271	29	7	3928	3928	NUM
dti-3271	29	8	www.aboutscience.eu/dti	www.aboutscience.eu/dti	NOUN
dti-3271	29	9	people	people	NOUN
dti-3271	29	10	but	but	CCONJ
dti-3271	29	11	not	not	PART
dti-3271	29	12	all	all	PRON
dti-3271	29	13	.	.	PUNCT
dti-3271	30	1	innovative	innovative	ADJ
dti-3271	30	2	anti	anti	ADJ
dti-3271	30	3	-	-	ADJ
dti-3271	30	4	diabetic	diabetic	ADJ
dti-3271	30	5	drugs	drug	NOUN
dti-3271	30	6	are	be	AUX
dti-3271	30	7	therefore	therefore	ADV
dti-3271	30	8	greatly	greatly	ADV
dti-3271	30	9	needed	need	VERB
dti-3271	30	10	.	.	PUNCT
dti-3271	31	1	diabetes	diabetes	NOUN
dti-3271	31	2	management	management	NOUN
dti-3271	31	3	requires	require	VERB
dti-3271	31	4	an	an	DET
dti-3271	31	5	extensive	extensive	ADJ
dti-3271	31	6	review	review	NOUN
dti-3271	31	7	of	of	ADP
dti-3271	31	8	current	current	ADJ
dti-3271	31	9	pharmacotherapies	pharmacotherapie	NOUN
dti-3271	31	10	and	and	CCONJ
dti-3271	31	11	phytotherapies	phytotherapy	NOUN
dti-3271	31	12	,	,	PUNCT
dti-3271	31	13	as	as	ADV
dti-3271	31	14	well	well	ADV
dti-3271	31	15	as	as	ADP
dti-3271	31	16	nutraceutical	nutraceutical	NOUN
dti-3271	31	17	-	-	PUNCT
dti-3271	31	18	based	base	VERB
dti-3271	31	19	therapies	therapy	NOUN
dti-3271	31	20	for	for	ADP
dti-3271	31	21	effective	effective	ADJ
dti-3271	31	22	management	management	NOUN
dti-3271	31	23	of	of	ADP
dti-3271	31	24	diabetes	diabetes	NOUN
dti-3271	31	25	,	,	PUNCT
dti-3271	31	26	along	along	ADP
dti-3271	31	27	with	with	ADP
dti-3271	31	28	their	their	PRON
dti-3271	31	29	merits	merit	NOUN
dti-3271	31	30	and	and	CCONJ
dti-3271	31	31	limitations	limitation	NOUN
dti-3271	31	32	(	(	PUNCT
dti-3271	31	33	6	6	NUM
dti-3271	31	34	)	)	PUNCT
dti-3271	31	35	.	.	PUNCT
dti-3271	32	1	the	the	DET
dti-3271	32	2	first	first	ADJ
dti-3271	32	3	known	know	VERB
dti-3271	32	4	oxindole	oxindole	NOUN
dti-3271	32	5	derivative	derivative	NOUN
dti-3271	32	6	was	be	AUX
dti-3271	32	7	discovered	discover	VERB
dti-3271	32	8	in	in	ADP
dti-3271	32	9	the	the	DET
dti-3271	32	10	form	form	NOUN
dti-3271	32	11	of	of	ADP
dti-3271	32	12	alkaloids	alkaloid	NOUN
dti-3271	32	13	from	from	ADP
dti-3271	32	14	the	the	DET
dti-3271	32	15	bark	bark	NOUN
dti-3271	32	16	of	of	ADP
dti-3271	32	17	the	the	DET
dti-3271	32	18	tropical	tropical	ADJ
dti-3271	32	19	climber	climber	NOUN
dti-3271	32	20	species	specie	NOUN
dti-3271	32	21	known	know	VERB
dti-3271	32	22	as	as	ADP
dti-3271	32	23	cat	cat	NOUN
dti-3271	32	24	claw	claw	NOUN
dti-3271	32	25	’s	’s	PART
dti-3271	32	26	plant	plant	NOUN
dti-3271	32	27	(	(	PUNCT
dti-3271	32	28	uncaria	uncaria	PROPN
dti-3271	32	29	tomentosa	tomentosa	PROPN
dti-3271	32	30	)	)	PUNCT
dti-3271	32	31	,	,	PUNCT
dti-3271	32	32	which	which	PRON
dti-3271	32	33	is	be	AUX
dti-3271	32	34	native	native	ADJ
dti-3271	32	35	to	to	ADP
dti-3271	32	36	the	the	DET
dti-3271	32	37	dense	dense	ADJ
dti-3271	32	38	rainforests	rainforest	NOUN
dti-3271	32	39	of	of	ADP
dti-3271	32	40	the	the	DET
dti-3271	32	41	amazon	amazon	NOUN
dti-3271	32	42	region	region	NOUN
dti-3271	32	43	and	and	CCONJ
dti-3271	32	44	other	other	ADJ
dti-3271	32	45	tropical	tropical	ADJ
dti-3271	32	46	regions	region	NOUN
dti-3271	32	47	of	of	ADP
dti-3271	32	48	central	central	ADJ
dti-3271	32	49	and	and	CCONJ
dti-3271	32	50	southern	southern	PROPN
dti-3271	32	51	south	south	PROPN
dti-3271	32	52	america	america	PROPN
dti-3271	32	53	(	(	PUNCT
dti-3271	32	54	7	7	NUM
dti-3271	32	55	)	)	PUNCT
dti-3271	32	56	.	.	PUNCT
dti-3271	33	1	oxindoles	oxindole	NOUN
dti-3271	33	2	are	be	AUX
dti-3271	33	3	naturally	naturally	ADV
dti-3271	33	4	occurring	occur	VERB
dti-3271	33	5	aromatic	aromatic	ADJ
dti-3271	33	6	chemical	chemical	NOUN
dti-3271	33	7	compounds	compound	NOUN
dti-3271	33	8	found	find	VERB
dti-3271	33	9	in	in	ADP
dti-3271	33	10	a	a	DET
dti-3271	33	11	variety	variety	NOUN
dti-3271	33	12	of	of	ADP
dti-3271	33	13	plant	plant	NOUN
dti-3271	33	14	materials	material	NOUN
dti-3271	33	15	as	as	ADV
dti-3271	33	16	well	well	ADV
dti-3271	33	17	as	as	ADP
dti-3271	33	18	in	in	ADP
dti-3271	33	19	animal	animal	NOUN
dti-3271	33	20	tissues	tissue	NOUN
dti-3271	33	21	and	and	CCONJ
dti-3271	33	22	body	body	NOUN
dti-3271	33	23	fluids	fluid	NOUN
dti-3271	33	24	.	.	PUNCT
dti-3271	34	1	a	a	DET
dti-3271	34	2	six	six	NUM
dti-3271	34	3	-	-	PUNCT
dti-3271	34	4	membered	membere	VERB
dti-3271	34	5	benzene	benzene	NOUN
dti-3271	34	6	ring	ring	NOUN
dti-3271	34	7	and	and	CCONJ
dti-3271	34	8	a	a	DET
dti-3271	34	9	five	five	NUM
dti-3271	34	10	-	-	PUNCT
dti-3271	34	11	membered	membere	VERB
dti-3271	34	12	ring	ring	NOUN
dti-3271	34	13	containing	contain	VERB
dti-3271	34	14	nitrogen	nitrogen	NOUN
dti-3271	34	15	combine	combine	NOUN
dti-3271	34	16	to	to	PART
dti-3271	34	17	form	form	VERB
dti-3271	34	18	an	an	DET
dti-3271	34	19	oxindole	oxindole	NOUN
dti-3271	34	20	(	(	PUNCT
dti-3271	34	21	8)	8)	NUM
dti-3271	34	22	.	.	PUNCT
dti-3271	35	1	several	several	ADJ
dti-3271	35	2	researchers	researcher	NOUN
dti-3271	35	3	have	have	AUX
dti-3271	35	4	discovered	discover	VERB
dti-3271	35	5	,	,	PUNCT
dti-3271	35	6	produced	produce	VERB
dti-3271	35	7	,	,	PUNCT
dti-3271	35	8	generated	generate	VERB
dti-3271	35	9	,	,	PUNCT
dti-3271	35	10	and	and	CCONJ
dti-3271	35	11	analyzed	analyze	VERB
dti-3271	35	12	oxindole	oxindole	NOUN
dti-3271	35	13	derivatives	derivative	NOUN
dti-3271	35	14	for	for	ADP
dti-3271	35	15	a	a	DET
dti-3271	35	16	range	range	NOUN
dti-3271	35	17	of	of	ADP
dti-3271	35	18	biological	biological	ADJ
dti-3271	35	19	effects	effect	NOUN
dti-3271	35	20	and	and	CCONJ
dti-3271	35	21	observed	observe	VERB
dti-3271	35	22	significant	significant	ADJ
dti-3271	35	23	effects	effect	NOUN
dti-3271	35	24	(	(	PUNCT
dti-3271	35	25	9	9	NUM
dti-3271	35	26	-	-	SYM
dti-3271	35	27	12	12	NUM
dti-3271	35	28	)	)	PUNCT
dti-3271	35	29	.	.	PUNCT
dti-3271	36	1	medicinal	medicinal	ADJ
dti-3271	36	2	chemists	chemist	NOUN
dti-3271	36	3	are	be	AUX
dti-3271	36	4	motivated	motivated	ADJ
dti-3271	36	5	to	to	PART
dti-3271	36	6	create	create	VERB
dti-3271	36	7	new	new	ADJ
dti-3271	36	8	oxindole	oxindole	NOUN
dti-3271	36	9	derivatives	derivative	NOUN
dti-3271	36	10	because	because	SCONJ
dti-3271	36	11	of	of	ADP
dti-3271	36	12	the	the	DET
dti-3271	36	13	oxindole	oxindole	NOUN
dti-3271	36	14	nucleus	nucleus	PROPN
dti-3271	36	15	’s	’s	PART
dti-3271	36	16	historical	historical	ADJ
dti-3271	36	17	and	and	CCONJ
dti-3271	36	18	current	current	ADJ
dti-3271	36	19	medicinal	medicinal	ADJ
dti-3271	36	20	value	value	NOUN
dti-3271	36	21	.	.	PUNCT
dti-3271	37	1	oxindole	oxindole	NOUN
dti-3271	37	2	-	-	PUNCT
dti-3271	37	3	derived	derive	VERB
dti-3271	37	4	compounds	compound	NOUN
dti-3271	37	5	are	be	AUX
dti-3271	37	6	potent	potent	ADJ
dti-3271	37	7	inhibitors	inhibitor	NOUN
dti-3271	37	8	of	of	ADP
dti-3271	37	9	the	the	DET
dti-3271	37	10	α	α	NOUN
dti-3271	37	11	-	-	PUNCT
dti-3271	37	12	glucosidase	glucosidase	ADJ
dti-3271	37	13	enzyme	enzyme	NOUN
dti-3271	37	14	,	,	PUNCT
dti-3271	37	15	which	which	PRON
dti-3271	37	16	is	be	AUX
dti-3271	37	17	a	a	DET
dti-3271	37	18	target	target	NOUN
dti-3271	37	19	enzyme	enzyme	NOUN
dti-3271	37	20	in	in	ADP
dti-3271	37	21	the	the	DET
dti-3271	37	22	treatment	treatment	NOUN
dti-3271	37	23	of	of	ADP
dti-3271	37	24	dm	dm	PROPN
dti-3271	37	25	(	(	PUNCT
dti-3271	37	26	13	13	NUM
dti-3271	37	27	)	)	PUNCT
dti-3271	37	28	.	.	PUNCT
dti-3271	38	1	the	the	DET
dti-3271	38	2	breakdown	breakdown	NOUN
dti-3271	38	3	and	and	CCONJ
dti-3271	38	4	intestinal	intestinal	ADJ
dti-3271	38	5	absorption	absorption	NOUN
dti-3271	38	6	of	of	ADP
dti-3271	38	7	carbohydrates	carbohydrate	NOUN
dti-3271	38	8	occur	occur	VERB
dti-3271	38	9	by	by	ADP
dti-3271	38	10	important	important	ADJ
dti-3271	38	11	enzymes	enzyme	NOUN
dti-3271	38	12	α	α	NOUN
dti-3271	38	13	-	-	NOUN
dti-3271	38	14	amylase	amylase	NOUN
dti-3271	38	15	and	and	CCONJ
dti-3271	38	16	α	α	NOUN
dti-3271	38	17	-	-	PUNCT
dti-3271	38	18	glucosidase	glucosidase	ADJ
dti-3271	38	19	,	,	PUNCT
dti-3271	38	20	respectively	respectively	ADV
dti-3271	38	21	.	.	PUNCT
dti-3271	39	1	the	the	DET
dti-3271	39	2	therapy	therapy	NOUN
dti-3271	39	3	of	of	ADP
dti-3271	39	4	non	non	ADJ
dti-3271	39	5	-	-	ADJ
dti-3271	39	6	insulin	insulin	ADJ
dti-3271	39	7	-	-	PUNCT
dti-3271	39	8	dependent	dependent	ADJ
dti-3271	39	9	dm	dm	PROPN
dti-3271	39	10	(	(	PUNCT
dti-3271	39	11	niddm	niddm	PROPN
dti-3271	39	12	)	)	PUNCT
dti-3271	39	13	can	can	AUX
dti-3271	39	14	benefit	benefit	VERB
dti-3271	39	15	greatly	greatly	ADV
dti-3271	39	16	from	from	ADP
dti-3271	39	17	the	the	DET
dti-3271	39	18	inhibition	inhibition	NOUN
dti-3271	39	19	of	of	ADP
dti-3271	39	20	these	these	DET
dti-3271	39	21	enzymes	enzyme	NOUN
dti-3271	39	22	,	,	PUNCT
dti-3271	39	23	which	which	PRON
dti-3271	39	24	inhibits	inhibit	VERB
dti-3271	39	25	the	the	DET
dti-3271	39	26	rise	rise	NOUN
dti-3271	39	27	in	in	ADP
dti-3271	39	28	blood	blood	NOUN
dti-3271	39	29	glucose	glucose	NOUN
dti-3271	39	30	levels	level	NOUN
dti-3271	39	31	following	follow	VERB
dti-3271	39	32	the	the	DET
dti-3271	39	33	consumption	consumption	NOUN
dti-3271	39	34	of	of	ADP
dti-3271	39	35	carbohydrates	carbohydrate	NOUN
dti-3271	39	36	(	(	PUNCT
dti-3271	39	37	14	14	NUM
dti-3271	39	38	)	)	PUNCT
dti-3271	39	39	.	.	PUNCT
dti-3271	40	1	similarly	similarly	ADV
dti-3271	40	2	,	,	PUNCT
dti-3271	40	3	2	2	NUM
dti-3271	40	4	,	,	PUNCT
dti-3271	40	5	3	3	NUM
dti-3271	40	6	and	and	CCONJ
dti-3271	40	7	2	2	NUM
dti-3271	40	8	,	,	PUNCT
dti-3271	40	9	6	6	NUM
dti-3271	40	10	-	-	PUNCT
dti-3271	40	11	dichloroindolinone	dichloroindolinone	NOUN
dti-3271	40	12	have	have	AUX
dti-3271	40	13	already	already	ADV
dti-3271	40	14	shown	show	VERB
dti-3271	40	15	potential	potential	ADJ
dti-3271	40	16	drug	drug	NOUN
dti-3271	40	17	-	-	PUNCT
dti-3271	40	18	like	like	ADJ
dti-3271	40	19	properties	property	NOUN
dti-3271	40	20	coupled	couple	VERB
dti-3271	40	21	with	with	ADP
dti-3271	40	22	antioxidant	antioxidant	ADJ
dti-3271	40	23	potential	potential	NOUN
dti-3271	40	24	(	(	PUNCT
dti-3271	40	25	15	15	NUM
dti-3271	40	26	)	)	PUNCT
dti-3271	40	27	.	.	PUNCT
dti-3271	41	1	in	in	ADP
dti-3271	41	2	the	the	DET
dti-3271	41	3	present	present	ADJ
dti-3271	41	4	article	article	NOUN
dti-3271	41	5	,	,	PUNCT
dti-3271	41	6	we	we	PRON
dti-3271	41	7	are	be	AUX
dti-3271	41	8	presenting	present	VERB
dti-3271	41	9	the	the	DET
dti-3271	41	10	in	in	ADV
dti-3271	41	11	vitro	vitro	X
dti-3271	41	12	α	α	NOUN
dti-3271	41	13	-	-	NOUN
dti-3271	41	14	glucosidase	glucosidase	ADJ
dti-3271	41	15	and	and	CCONJ
dti-3271	41	16	α	α	NOUN
dti-3271	41	17	-	-	PUNCT
dti-3271	41	18	amylase	amylase	NOUN
dti-3271	41	19	activities	activity	NOUN
dti-3271	41	20	of	of	ADP
dti-3271	41	21	oxindoles	oxindole	NOUN
dti-3271	41	22	,	,	PUNCT
dti-3271	41	23	2	2	NUM
dti-3271	41	24	,	,	PUNCT
dti-3271	41	25	3	3	NUM
dti-3271	41	26	dichloroindolinone	dichloroindolinone	NOUN
dti-3271	41	27	(	(	PUNCT
dti-3271	41	28	c1	c1	PROPN
dti-3271	41	29	)	)	PUNCT
dti-3271	41	30	and	and	CCONJ
dti-3271	41	31	2	2	NUM
dti-3271	41	32	,	,	PUNCT
dti-3271	41	33	6	6	NUM
dti-3271	41	34	-	-	PUNCT
dti-3271	41	35	dichloroindolinone	dichloroindolinone	NOUN
dti-3271	41	36	(	(	PUNCT
dti-3271	41	37	c2	c2	PROPN
dti-3271	41	38	)	)	PUNCT
dti-3271	41	39	(	(	PUNCT
dti-3271	41	40	figure	figure	NOUN
dti-3271	41	41	1	1	NUM
dti-3271	41	42	)	)	PUNCT
dti-3271	41	43	followed	follow	VERB
dti-3271	41	44	by	by	ADP
dti-3271	41	45	molecular	molecular	ADJ
dti-3271	41	46	docking	docking	NOUN
dti-3271	41	47	and	and	CCONJ
dti-3271	41	48	molecular	molecular	ADJ
dti-3271	41	49	dynamic	dynamic	ADJ
dti-3271	41	50	simulation	simulation	NOUN
dti-3271	41	51	.	.	PUNCT
dti-3271	42	1	materials	material	NOUN
dti-3271	42	2	and	and	CCONJ
dti-3271	42	3	methods	method	NOUN
dti-3271	42	4	chemicals	chemical	NOUN
dti-3271	42	5	chemicals	chemical	NOUN
dti-3271	42	6	used	use	VERB
dti-3271	42	7	were	be	AUX
dti-3271	42	8	α	α	NOUN
dti-3271	42	9	-	-	NOUN
dti-3271	42	10	glucosidase	glucosidase	ADJ
dti-3271	42	11	,	,	PUNCT
dti-3271	42	12	α	α	NOUN
dti-3271	42	13	-	-	PUNCT
dti-3271	42	14	amylase	amylase	NOUN
dti-3271	42	15	,	,	PUNCT
dti-3271	42	16	acarbose	acarbose	NOUN
dti-3271	42	17	,	,	PUNCT
dti-3271	42	18	glucopyranoside	glucopyranoside	NOUN
dti-3271	42	19	,	,	PUNCT
dti-3271	42	20	phosphate	phosphate	ADJ
dti-3271	42	21	buffer	buffer	NOUN
dti-3271	42	22	,	,	PUNCT
dti-3271	42	23	and	and	CCONJ
dti-3271	42	24	piperidine	piperidine	NOUN
dti-3271	42	25	,	,	PUNCT
dti-3271	42	26	na2co3	na2co3	PROPN
dti-3271	42	27	,	,	PUNCT
dti-3271	42	28	starch	starch	NOUN
dti-3271	42	29	and	and	CCONJ
dti-3271	42	30	dinitro	dinitro	ADJ
dti-3271	42	31	salicylic	salicylic	ADJ
dti-3271	42	32	acid	acid	PROPN
dti-3271	42	33	-solution	-solution	PROPN
dti-3271	42	34	,	,	PUNCT
dti-3271	42	35	hydrochloric	hydrochloric	ADJ
dti-3271	42	36	acid	acid	NOUN
dti-3271	42	37	and	and	CCONJ
dti-3271	42	38	distilled	distil	VERB
dti-3271	42	39	water	water	NOUN
dti-3271	42	40	.	.	PUNCT
dti-3271	43	1	α	α	X
dti-3271	43	2	-	-	ADJ
dti-3271	43	3	glucosidase	glucosidase	ADJ
dti-3271	43	4	activity	activity	NOUN
dti-3271	43	5	in	in	ADP
dti-3271	43	6	this	this	DET
dti-3271	43	7	test	test	NOUN
dti-3271	43	8	,	,	PUNCT
dti-3271	43	9	glucopyranoside	glucopyranoside	PROPN
dti-3271	43	10	is	be	AUX
dti-3271	43	11	incorporated	incorporate	VERB
dti-3271	43	12	into	into	ADP
dti-3271	43	13	the	the	DET
dti-3271	43	14	solvent	solvent	NOUN
dti-3271	43	15	(	(	PUNCT
dti-3271	43	16	phosphate	phosphate	ADJ
dti-3271	43	17	buffer	buffer	NOUN
dti-3271	43	18	)	)	PUNCT
dti-3271	43	19	.	.	PUNCT
dti-3271	44	1	several	several	ADJ
dti-3271	44	2	doses	dose	NOUN
dti-3271	44	3	of	of	ADP
dti-3271	44	4	the	the	DET
dti-3271	44	5	synthesized	synthesize	VERB
dti-3271	44	6	compounds	compound	NOUN
dti-3271	44	7	,	,	PUNCT
dti-3271	44	8	including	include	VERB
dti-3271	44	9	62.5	62.5	NUM
dti-3271	44	10	µg	µg	NOUN
dti-3271	44	11	/	/	SYM
dti-3271	44	12	ml	ml	NOUN
dti-3271	44	13	,	,	PUNCT
dti-3271	44	14	125	125	NUM
dti-3271	44	15	µg	µg	ADJ
dti-3271	44	16	/	/	SYM
dti-3271	44	17	ml	ml	NOUN
dti-3271	44	18	,	,	PUNCT
dti-3271	44	19	250	250	NUM
dti-3271	44	20	µg	µg	ADV
dti-3271	44	21	/	/	SYM
dti-3271	44	22	ml	ml	NOUN
dti-3271	44	23	,	,	PUNCT
dti-3271	44	24	500	500	NUM
dti-3271	44	25	µg	µg	NOUN
dti-3271	44	26	/	/	SYM
dti-3271	44	27	ml	ml	NOUN
dti-3271	44	28	,	,	PUNCT
dti-3271	44	29	and	and	CCONJ
dti-3271	44	30	1000	1000	NUM
dti-3271	44	31	µg	µg	NOUN
dti-3271	44	32	/	/	SYM
dti-3271	44	33	ml	ml	NOUN
dti-3271	44	34	,	,	PUNCT
dti-3271	44	35	were	be	AUX
dti-3271	44	36	used	use	VERB
dti-3271	44	37	to	to	PART
dti-3271	44	38	create	create	VERB
dti-3271	44	39	the	the	DET
dti-3271	44	40	sample	sample	NOUN
dti-3271	44	41	solutions	solution	NOUN
dti-3271	44	42	.	.	PUNCT
dti-3271	45	1	added	add	VERB
dti-3271	45	2	0.5	0.5	NUM
dti-3271	45	3	µg	µg	NOUN
dti-3271	45	4	/	/	SYM
dti-3271	45	5	ml	ml	NOUN
dti-3271	45	6	of	of	ADP
dti-3271	45	7	glucosidase	glucosidase	NOUN
dti-3271	45	8	in	in	ADP
dti-3271	45	9	distilled	distil	VERB
dti-3271	45	10	water	water	NOUN
dti-3271	45	11	to	to	ADP
dti-3271	45	12	the	the	DET
dti-3271	45	13	mixture	mixture	NOUN
dti-3271	45	14	described	describe	VERB
dti-3271	45	15	above	above	ADV
dti-3271	45	16	.	.	PUNCT
dti-3271	46	1	subsequently	subsequently	ADV
dti-3271	46	2	,	,	PUNCT
dti-3271	46	3	the	the	DET
dti-3271	46	4	resultant	resultant	NOUN
dti-3271	46	5	mixture	mixture	NOUN
dti-3271	46	6	was	be	AUX
dti-3271	46	7	incubated	incubate	VERB
dti-3271	46	8	at	at	ADP
dti-3271	46	9	37	37	NUM
dti-3271	46	10	°	°	ADP
dti-3271	46	11	c	c	NOUN
dti-3271	46	12	for	for	ADP
dti-3271	46	13	20	20	NUM
dti-3271	46	14	minutes	minute	NOUN
dti-3271	46	15	(	(	PUNCT
dti-3271	46	16	16	16	NUM
dti-3271	46	17	)	)	PUNCT
dti-3271	46	18	.	.	PUNCT
dti-3271	47	1	hydrochloric	hydrochloric	PROPN
dti-3271	47	2	acid	acid	PROPN
dti-3271	47	3	was	be	AUX
dti-3271	47	4	used	use	VERB
dti-3271	47	5	to	to	PART
dti-3271	47	6	stop	stop	VERB
dti-3271	47	7	the	the	DET
dti-3271	47	8	reaction	reaction	NOUN
dti-3271	47	9	mixture	mixture	NOUN
dti-3271	47	10	after	after	ADP
dti-3271	47	11	the	the	DET
dti-3271	47	12	incubation	incubation	NOUN
dti-3271	47	13	period	period	NOUN
dti-3271	47	14	.	.	PUNCT
dti-3271	48	1	using	use	VERB
dti-3271	48	2	a	a	DET
dti-3271	48	3	spectrophotometer	spectrophotometer	NOUN
dti-3271	48	4	,	,	PUNCT
dti-3271	48	5	the	the	DET
dti-3271	48	6	color	color	NOUN
dti-3271	48	7	intensity	intensity	NOUN
dti-3271	48	8	was	be	AUX
dti-3271	48	9	determined	determine	VERB
dti-3271	48	10	at	at	ADP
dti-3271	48	11	a	a	DET
dti-3271	48	12	wavelength	wavelength	NOUN
dti-3271	48	13	of	of	ADP
dti-3271	48	14	540	540	NUM
dti-3271	48	15	nm	nm	NOUN
dti-3271	48	16	.	.	PUNCT
dti-3271	49	1	the	the	DET
dti-3271	49	2	percentage	percentage	NOUN
dti-3271	49	3	inhibition	inhibition	NOUN
dti-3271	49	4	was	be	AUX
dti-3271	49	5	computed	compute	VERB
dti-3271	49	6	using	use	VERB
dti-3271	49	7	the	the	DET
dti-3271	49	8	following	follow	VERB
dti-3271	49	9	equation	equation	NOUN
dti-3271	49	10	:	:	PUNCT
dti-3271	49	11	inhibition	inhibition	NOUN
dti-3271	49	12	(	(	PUNCT
dti-3271	49	13	%	%	INTJ
dti-3271	49	14	)	)	PUNCT
dti-3271	50	1	=	=	SYM
dti-3271	50	2	(	(	PUNCT
dti-3271	50	3	control	control	NOUN
dti-3271	50	4	abs	ab	NOUN
dti-3271	50	5	−	−	NOUN
dti-3271	50	6	test	test	NOUN
dti-3271	50	7	abs	ab	NOUN
dti-3271	50	8	/	/	SYM
dti-3271	50	9	control	control	NOUN
dti-3271	50	10	abs	ab	NOUN
dti-3271	50	11	)	)	PUNCT
dti-3271	50	12	×	×	NOUN
dti-3271	50	13	100	100	NUM
dti-3271	50	14	α	α	NUM
dti-3271	50	15	-	-	PUNCT
dti-3271	50	16	amylase	amylase	NOUN
dti-3271	50	17	activity	activity	NOUN
dti-3271	50	18	in	in	ADP
dti-3271	50	19	this	this	DET
dti-3271	50	20	assay	assay	NOUN
dti-3271	50	21	,	,	PUNCT
dti-3271	50	22	previously	previously	ADV
dti-3271	50	23	published	publish	VERB
dti-3271	50	24	techniques	technique	NOUN
dti-3271	50	25	were	be	AUX
dti-3271	50	26	applied	apply	VERB
dti-3271	50	27	(	(	PUNCT
dti-3271	50	28	16	16	NUM
dti-3271	50	29	)	)	PUNCT
dti-3271	50	30	.	.	PUNCT
dti-3271	51	1	α	α	X
dti-3271	51	2	-	-	PUNCT
dti-3271	51	3	amylase	amylase	NOUN
dti-3271	51	4	,	,	PUNCT
dti-3271	51	5	phosphate	phosphate	ADJ
dti-3271	51	6	buffer	buffer	NOUN
dti-3271	51	7	,	,	PUNCT
dti-3271	51	8	and	and	CCONJ
dti-3271	51	9	the	the	DET
dti-3271	51	10	sample	sample	NOUN
dti-3271	51	11	solution	solution	NOUN
dti-3271	51	12	were	be	AUX
dti-3271	51	13	prepared	prepare	VERB
dti-3271	51	14	by	by	ADP
dti-3271	51	15	combining	combine	VERB
dti-3271	51	16	different	different	ADJ
dti-3271	51	17	amounts	amount	NOUN
dti-3271	51	18	of	of	ADP
dti-3271	51	19	the	the	DET
dti-3271	51	20	produced	produce	VERB
dti-3271	51	21	compounds	compound	NOUN
dti-3271	51	22	(	(	PUNCT
dti-3271	51	23	62.5	62.5	NUM
dti-3271	51	24	µg	µg	NOUN
dti-3271	51	25	/	/	SYM
dti-3271	51	26	ml	ml	NOUN
dti-3271	51	27	,	,	PUNCT
dti-3271	51	28	125	125	NUM
dti-3271	51	29	µg	µg	ADJ
dti-3271	51	30	/	/	SYM
dti-3271	51	31	ml	ml	NOUN
dti-3271	51	32	,	,	PUNCT
dti-3271	51	33	250	250	NUM
dti-3271	51	34	µg	µg	ADV
dti-3271	51	35	/	/	SYM
dti-3271	51	36	ml	ml	NOUN
dti-3271	51	37	,	,	PUNCT
dti-3271	51	38	500	500	NUM
dti-3271	51	39	µg	µg	NOUN
dti-3271	51	40	/	/	SYM
dti-3271	51	41	ml	ml	NOUN
dti-3271	51	42	,	,	PUNCT
dti-3271	51	43	and	and	CCONJ
dti-3271	51	44	1000	1000	NUM
dti-3271	51	45	µg	µg	NOUN
dti-3271	51	46	/	/	SYM
dti-3271	51	47	ml	ml	NOUN
dti-3271	51	48	)	)	PUNCT
dti-3271	51	49	.	.	PUNCT
dti-3271	52	1	after	after	ADP
dti-3271	52	2	mixing	mix	VERB
dti-3271	52	3	this	this	DET
dti-3271	52	4	solution	solution	NOUN
dti-3271	52	5	with	with	ADP
dti-3271	52	6	the	the	DET
dti-3271	52	7	starch	starch	NOUN
dti-3271	52	8	solution	solution	NOUN
dti-3271	52	9	,	,	PUNCT
dti-3271	52	10	the	the	DET
dti-3271	52	11	mixture	mixture	NOUN
dti-3271	52	12	was	be	AUX
dti-3271	52	13	left	leave	VERB
dti-3271	52	14	to	to	PART
dti-3271	52	15	incubate	incubate	VERB
dti-3271	52	16	for	for	ADP
dti-3271	52	17	around	around	ADV
dti-3271	52	18	20	20	NUM
dti-3271	52	19	minutes	minute	NOUN
dti-3271	52	20	at	at	ADP
dti-3271	52	21	37	37	NUM
dti-3271	52	22	°	°	NOUN
dti-3271	52	23	c	c	NOUN
dti-3271	52	24	.	.	PUNCT
dti-3271	53	1	following	follow	VERB
dti-3271	53	2	incubation	incubation	NOUN
dti-3271	53	3	,	,	PUNCT
dti-3271	53	4	the	the	DET
dti-3271	53	5	reactant	reactant	NOUN
dti-3271	53	6	mixture	mixture	NOUN
dti-3271	53	7	was	be	AUX
dti-3271	53	8	just	just	ADV
dti-3271	53	9	maintained	maintain	VERB
dti-3271	53	10	at	at	ADP
dti-3271	53	11	100	100	NUM
dti-3271	53	12	°	°	NOUN
dti-3271	53	13	c	c	NOUN
dti-3271	53	14	in	in	ADP
dti-3271	53	15	a	a	DET
dti-3271	53	16	water	water	NOUN
dti-3271	53	17	bath	bath	NOUN
dti-3271	53	18	.	.	PUNCT
dti-3271	54	1	at	at	ADP
dti-3271	54	2	656	656	NUM
dti-3271	54	3	nm	nm	NOUN
dti-3271	54	4	,	,	PUNCT
dti-3271	54	5	the	the	DET
dti-3271	54	6	color	color	NOUN
dti-3271	54	7	intensity	intensity	NOUN
dti-3271	54	8	was	be	AUX
dti-3271	54	9	determined	determine	VERB
dti-3271	54	10	using	use	VERB
dti-3271	54	11	a	a	DET
dti-3271	54	12	microplate	microplate	NOUN
dti-3271	54	13	reader	reader	NOUN
dti-3271	54	14	.	.	PUNCT
dti-3271	55	1	the	the	DET
dti-3271	55	2	following	follow	VERB
dti-3271	55	3	formula	formula	NOUN
dti-3271	55	4	was	be	AUX
dti-3271	55	5	used	use	VERB
dti-3271	55	6	to	to	PART
dti-3271	55	7	get	get	VERB
dti-3271	55	8	the	the	DET
dti-3271	55	9	inhibition	inhibition	NOUN
dti-3271	55	10	percentage	percentage	NOUN
dti-3271	55	11	.	.	PUNCT
dti-3271	56	1	inhibition	inhibition	NOUN
dti-3271	56	2	(	(	PUNCT
dti-3271	56	3	%	%	INTJ
dti-3271	56	4	)	)	PUNCT
dti-3271	56	5	=	=	SYM
dti-3271	56	6	(	(	PUNCT
dti-3271	56	7	control	control	NOUN
dti-3271	56	8	abs	ab	NOUN
dti-3271	56	9	test	test	NOUN
dti-3271	56	10	abs	ab	NOUN
dti-3271	56	11	/	/	SYM
dti-3271	56	12	control	control	NOUN
dti-3271	56	13	abs	ab	NOUN
dti-3271	56	14	)	)	PUNCT
dti-3271	56	15	x	x	SYM
dti-3271	56	16	100	100	NUM
dti-3271	56	17	molecular	molecular	ADJ
dti-3271	56	18	docking	dock	VERB
dti-3271	56	19	the	the	DET
dti-3271	56	20	synergistic	synergistic	ADJ
dti-3271	56	21	effect	effect	NOUN
dti-3271	56	22	of	of	ADP
dti-3271	56	23	characteristics	characteristic	NOUN
dti-3271	56	24	of	of	ADP
dti-3271	56	25	active	active	ADJ
dti-3271	56	26	compounds	compound	NOUN
dti-3271	56	27	c1	c1	PROPN
dti-3271	56	28	and	and	CCONJ
dti-3271	56	29	c2	c2	PROPN
dti-3271	56	30	on	on	ADP
dti-3271	56	31	α	α	NOUN
dti-3271	56	32	-	-	NOUN
dti-3271	56	33	glucosidase	glucosidase	ADJ
dti-3271	56	34	and	and	CCONJ
dti-3271	56	35	α	α	NOUN
dti-3271	56	36	-	-	PUNCT
dti-3271	56	37	amylase	amylase	NOUN
dti-3271	56	38	inhibitory	inhibitory	ADJ
dti-3271	56	39	actions	action	NOUN
dti-3271	56	40	was	be	AUX
dti-3271	56	41	investigated	investigate	VERB
dti-3271	56	42	using	use	VERB
dti-3271	56	43	molecular	molecular	ADJ
dti-3271	56	44	docking	docking	NOUN
dti-3271	56	45	studies	study	NOUN
dti-3271	56	46	(	(	PUNCT
dti-3271	56	47	17	17	NUM
dti-3271	56	48	)	)	PUNCT
dti-3271	56	49	.	.	PUNCT
dti-3271	57	1	the	the	DET
dti-3271	57	2	protein	protein	NOUN
dti-3271	57	3	data	datum	NOUN
dti-3271	57	4	bank	bank	PROPN
dti-3271	57	5	provided	provide	VERB
dti-3271	57	6	the	the	DET
dti-3271	57	7	α	α	NOUN
dti-3271	57	8	-	-	NOUN
dti-3271	57	9	glucosidase	glucosidase	ADJ
dti-3271	57	10	and	and	CCONJ
dti-3271	57	11	α	α	NOUN
dti-3271	57	12	-	-	PUNCT
dti-3271	57	13	amylase	amylase	NOUN
dti-3271	57	14	pdb	pdb	NOUN
dti-3271	57	15	ids	id	NOUN
dti-3271	57	16	,	,	PUNCT
dti-3271	57	17	which	which	PRON
dti-3271	57	18	are	be	AUX
dti-3271	57	19	5nn5	5nn5	NUM
dti-3271	57	20	and	and	CCONJ
dti-3271	57	21	4gqr	4gqr	NUM
dti-3271	57	22	,	,	PUNCT
dti-3271	57	23	respectively	respectively	ADV
dti-3271	57	24	.	.	PUNCT
dti-3271	58	1	molecular	molecular	ADJ
dti-3271	58	2	dynamic	dynamic	ADJ
dti-3271	58	3	simulation	simulation	NOUN
dti-3271	58	4	we	we	PRON
dti-3271	58	5	calculated	calculate	VERB
dti-3271	58	6	the	the	DET
dti-3271	58	7	parameters	parameter	NOUN
dti-3271	58	8	,	,	PUNCT
dti-3271	58	9	including	include	VERB
dti-3271	58	10	binding	bind	VERB
dti-3271	58	11	free	free	ADJ
dti-3271	58	12	energy	energy	NOUN
dti-3271	58	13	,	,	PUNCT
dti-3271	58	14	van	van	PROPN
dti-3271	58	15	der	der	NOUN
dti-3271	58	16	waals	waal	NOUN
dti-3271	58	17	energy	energy	NOUN
dti-3271	58	18	,	,	PUNCT
dti-3271	58	19	electrostatic	electrostatic	ADJ
dti-3271	58	20	energy	energy	NOUN
dti-3271	58	21	,	,	PUNCT
dti-3271	58	22	kinetic	kinetic	ADJ
dti-3271	58	23	energy	energy	NOUN
dti-3271	58	24	,	,	PUNCT
dti-3271	58	25	and	and	CCONJ
dti-3271	58	26	potential	potential	ADJ
dti-3271	58	27	energy	energy	NOUN
dti-3271	58	28	changes	change	NOUN
dti-3271	58	29	using	use	VERB
dti-3271	58	30	molecular	molecular	ADJ
dti-3271	58	31	dynamics	dynamic	NOUN
dti-3271	58	32	simulations	simulation	NOUN
dti-3271	58	33	.	.	PUNCT
dti-3271	59	1	furthermore	furthermore	ADV
dti-3271	59	2	,	,	PUNCT
dti-3271	59	3	we	we	PRON
dti-3271	59	4	investigated	investigate	VERB
dti-3271	59	5	the	the	DET
dti-3271	59	6	interactions	interaction	NOUN
dti-3271	59	7	that	that	SCONJ
dti-3271	59	8	these	these	DET
dti-3271	59	9	compounds	compound	NOUN
dti-3271	59	10	had	have	VERB
dti-3271	59	11	with	with	ADP
dti-3271	59	12	the	the	DET
dti-3271	59	13	proteins	protein	NOUN
dti-3271	59	14	,	,	PUNCT
dti-3271	59	15	glucosidase	glucosidase	ADJ
dti-3271	59	16	,	,	PUNCT
dti-3271	59	17	and	and	CCONJ
dti-3271	59	18	amylase	amylase	NOUN
dti-3271	59	19	throughout	throughout	ADP
dti-3271	59	20	a	a	DET
dti-3271	59	21	time	time	NOUN
dti-3271	59	22	span	span	NOUN
dti-3271	59	23	of	of	ADP
dti-3271	59	24	0	0	NUM
dti-3271	59	25	to	to	PART
dti-3271	59	26	250	250	NUM
dti-3271	59	27	ns	ns	NUM
dti-3271	59	28	.	.	PUNCT
dti-3271	60	1	the	the	DET
dti-3271	60	2	binding	bind	VERB
dti-3271	60	3	free	free	ADJ
dti-3271	60	4	energy	energy	NOUN
dti-3271	60	5	change	change	NOUN
dti-3271	60	6	values	value	NOUN
dti-3271	60	7	for	for	ADP
dti-3271	60	8	the	the	DET
dti-3271	60	9	two	two	NUM
dti-3271	60	10	compounds	compound	NOUN
dti-3271	60	11	interacting	interact	VERB
dti-3271	60	12	with	with	ADP
dti-3271	60	13	the	the	DET
dti-3271	60	14	proteins	protein	NOUN
dti-3271	60	15	were	be	AUX
dti-3271	60	16	also	also	ADV
dti-3271	60	17	computed	compute	VERB
dti-3271	60	18	(	(	PUNCT
dti-3271	60	19	18	18	NUM
dti-3271	60	20	)	)	PUNCT
dti-3271	60	21	.	.	PUNCT
dti-3271	61	1	the	the	DET
dti-3271	61	2	docking	docking	NOUN
dti-3271	61	3	analysis	analysis	NOUN
dti-3271	61	4	was	be	AUX
dti-3271	61	5	performed	perform	VERB
dti-3271	61	6	to	to	PART
dti-3271	61	7	explicate	explicate	VERB
dti-3271	61	8	the	the	DET
dti-3271	61	9	potency	potency	NOUN
dti-3271	61	10	of	of	ADP
dti-3271	61	11	these	these	DET
dti-3271	61	12	desirable	desirable	ADJ
dti-3271	61	13	molecules	molecule	NOUN
dti-3271	61	14	in	in	ADP
dti-3271	61	15	vitro	vitro	X
dti-3271	61	16	against	against	ADP
dti-3271	61	17	the	the	DET
dti-3271	61	18	epidermal	epidermal	ADJ
dti-3271	61	19	growth	growth	NOUN
dti-3271	61	20	factor	factor	NOUN
dti-3271	61	21	receptor	receptor	NOUN
dti-3271	61	22	(	(	PUNCT
dti-3271	61	23	egfr	egfr	X
dti-3271	61	24	)	)	PUNCT
dti-3271	61	25	kinase	kinase	NOUN
dti-3271	61	26	through	through	ADP
dti-3271	61	27	their	their	PRON
dti-3271	61	28	potential	potential	ADJ
dti-3271	61	29	interaction	interaction	NOUN
dti-3271	61	30	mechanisms	mechanism	NOUN
dti-3271	61	31	with	with	ADP
dti-3271	61	32	their	their	PRON
dti-3271	61	33	crystal	crystal	NOUN
dti-3271	61	34	frameworks	framework	NOUN
dti-3271	61	35	(	(	PUNCT
dti-3271	61	36	pdb	pdb	NOUN
dti-3271	61	37	:	:	PUNCT
dti-3271	61	38	1b2y	1b2y	NUM
dti-3271	61	39	(	(	PUNCT
dti-3271	61	40	19	19	NUM
dti-3271	61	41	)	)	PUNCT
dti-3271	61	42	,	,	PUNCT
dti-3271	61	43	pdb	pdb	NOUN
dti-3271	61	44	:	:	PUNCT
dti-3271	61	45	3a4a	3a4a	NUM
dti-3271	61	46	)	)	PUNCT
dti-3271	61	47	(	(	PUNCT
dti-3271	61	48	20	20	NUM
dti-3271	61	49	)	)	PUNCT
dti-3271	61	50	)	)	PUNCT
dti-3271	61	51	.	.	PUNCT
dti-3271	62	1	the	the	DET
dti-3271	62	2	docking	docking	NOUN
dti-3271	62	3	investigation	investigation	NOUN
dti-3271	62	4	was	be	AUX
dti-3271	62	5	implemented	implement	VERB
dti-3271	62	6	through	through	ADP
dti-3271	62	7	glide	glide	NOUN
dti-3271	62	8	’s	’s	PART
dti-3271	62	9	module	module	NOUN
dti-3271	62	10	®	®	NOUN
dti-3271	62	11	.	.	PUNCT
dti-3271	63	1	the	the	DET
dti-3271	63	2	preliminary	preliminary	ADJ
dti-3271	63	3	inhibitors	inhibitor	NOUN
dti-3271	63	4	(	(	PUNCT
dti-3271	63	5	acarbose	acarbose	NOUN
dti-3271	63	6	)	)	PUNCT
dti-3271	63	7	were	be	AUX
dti-3271	63	8	relocked	relocke	VERB
dti-3271	63	9	into	into	ADP
dti-3271	63	10	the	the	DET
dti-3271	63	11	α	α	NOUN
dti-3271	63	12	-	-	PUNCT
dti-3271	63	13	amylase	amylase	NOUN
dti-3271	63	14	crystal	crystal	NOUN
dti-3271	63	15	framework	framework	NOUN
dti-3271	63	16	to	to	PART
dti-3271	63	17	verify	verify	VERB
dti-3271	63	18	the	the	DET
dti-3271	63	19	docking	docking	NOUN
dti-3271	63	20	methodology	methodology	NOUN
dti-3271	63	21	.	.	PUNCT
dti-3271	64	1	furthermore	furthermore	ADV
dti-3271	64	2	,	,	PUNCT
dti-3271	64	3	the	the	DET
dti-3271	64	4	efficacious	efficacious	ADJ
dti-3271	64	5	performance	performance	NOUN
dti-3271	64	6	of	of	ADP
dti-3271	64	7	the	the	DET
dti-3271	64	8	targeted	target	VERB
dti-3271	64	9	molecules	molecule	NOUN
dti-3271	64	10	was	be	AUX
dti-3271	64	11	authenticated	authenticate	VERB
dti-3271	64	12	via	via	ADP
dti-3271	64	13	the	the	DET
dti-3271	64	14	low	low	ADJ
dti-3271	64	15	values	value	NOUN
dti-3271	64	16	of	of	ADP
dti-3271	64	17	rmsd	rmsd	NOUN
dti-3271	64	18	(	(	PUNCT
dti-3271	64	19	1.02	1.02	NUM
dti-3271	64	20	respectively	respectively	ADV
dti-3271	64	21	)	)	PUNCT
dti-3271	64	22	,	,	PUNCT
dti-3271	64	23	which	which	PRON
dti-3271	64	24	were	be	AUX
dti-3271	64	25	acquired	acquire	VERB
dti-3271	64	26	through	through	ADP
dti-3271	64	27	the	the	DET
dti-3271	64	28	figure	figure	NOUN
dti-3271	64	29	1	1	NUM
dti-3271	64	30	structures	structure	NOUN
dti-3271	64	31	of	of	ADP
dti-3271	64	32	test	test	NOUN
dti-3271	64	33	compounds	compound	NOUN
dti-3271	64	34	.	.	PUNCT
dti-3271	65	1	https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/salicylic-acid	https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/salicylic-acid	PROPN
dti-3271	65	2	rauf	rauf	PROPN
dti-3271	65	3	et	et	PROPN
dti-3271	65	4	al	al	PROPN
dti-3271	65	5	drug	drug	PROPN
dti-3271	65	6	target	target	NOUN
dti-3271	65	7	insights	insight	NOUN
dti-3271	65	8	2025	2025	NUM
dti-3271	65	9	;	;	PUNCT
dti-3271	65	10	19	19	NUM
dti-3271	65	11	:	:	SYM
dti-3271	65	12	13	13	NUM
dti-3271	65	13	©	©	ADP
dti-3271	65	14	2025	2025	NUM
dti-3271	65	15	the	the	DET
dti-3271	65	16	authors	author	NOUN
dti-3271	65	17	.	.	PUNCT
dti-3271	66	1	published	publish	VERB
dti-3271	66	2	by	by	ADP
dti-3271	66	3	aboutscience	aboutscience	NOUN
dti-3271	66	4	www.aboutscience.eu	www.aboutscience.eu	NOUN
dti-3271	66	5	root	root	NOUN
dti-3271	66	6	mean	mean	ADJ
dti-3271	66	7	square	square	ADJ
dti-3271	66	8	deviation	deviation	NOUN
dti-3271	66	9	between	between	ADP
dti-3271	66	10	the	the	DET
dti-3271	66	11	native	native	ADJ
dti-3271	66	12	and	and	CCONJ
dti-3271	66	13	relocked	relocked	ADJ
dti-3271	66	14	poses	pose	NOUN
dti-3271	66	15	of	of	ADP
dti-3271	66	16	the	the	DET
dti-3271	66	17	co	co	ADJ
dti-3271	66	18	-	-	ADJ
dti-3271	66	19	crystallized	crystallized	ADJ
dti-3271	66	20	inhibitor	inhibitor	NOUN
dti-3271	66	21	.	.	PUNCT
dti-3271	67	1	statistical	statistical	ADJ
dti-3271	67	2	analysis	analysis	NOUN
dti-3271	67	3	the	the	DET
dti-3271	67	4	data	data	NOUN
dti-3271	67	5	is	be	AUX
dti-3271	67	6	illustrated	illustrate	VERB
dti-3271	67	7	as	as	ADP
dti-3271	67	8	mean	mean	NOUN
dti-3271	67	9	±	±	NUM
dti-3271	67	10	sem	sem	NOUN
dti-3271	67	11	of	of	ADP
dti-3271	67	12	three	three	NUM
dti-3271	67	13	distinct	distinct	ADJ
dti-3271	67	14	measurements	measurement	NOUN
dti-3271	67	15	.	.	PUNCT
dti-3271	68	1	analyisis	analyisis	NOUN
dti-3271	68	2	of	of	ADP
dti-3271	68	3	variance	variance	NOUN
dti-3271	68	4	(	(	PUNCT
dti-3271	68	5	anova	anova	PROPN
dti-3271	68	6	)	)	PUNCT
dti-3271	68	7	at	at	ADP
dti-3271	68	8	*	*	PUNCT
dti-3271	68	9	p	p	X
dti-3271	68	10	<	<	X
dti-3271	68	11	0.05	0.05	NUM
dti-3271	68	12	and	and	CCONJ
dti-3271	68	13	the	the	DET
dti-3271	68	14	bonferroni	bonferroni	NOUN
dti-3271	68	15	test	test	NOUN
dti-3271	68	16	showed	show	VERB
dti-3271	68	17	static	static	ADJ
dti-3271	68	18	significance	significance	NOUN
dti-3271	68	19	using	use	VERB
dti-3271	68	20	graphpad	graphpad	NOUN
dti-3271	68	21	version	version	NOUN
dti-3271	68	22	8	8	NUM
dti-3271	68	23	.	.	PUNCT
dti-3271	69	1	results	result	VERB
dti-3271	69	2	effects	effect	NOUN
dti-3271	69	3	of	of	ADP
dti-3271	69	4	compounds	compound	NOUN
dti-3271	69	5	on	on	ADP
dti-3271	69	6	α	α	NOUN
dti-3271	69	7	-	-	PUNCT
dti-3271	69	8	glucosidase	glucosidase	ADJ
dti-3271	69	9	inhibition	inhibition	NOUN
dti-3271	69	10	figure	figure	NOUN
dti-3271	69	11	2	2	NUM
dti-3271	69	12	shows	show	VERB
dti-3271	69	13	the	the	DET
dti-3271	69	14	α	α	NOUN
dti-3271	69	15	-	-	PUNCT
dti-3271	69	16	glucosidase	glucosidase	ADJ
dti-3271	69	17	inhibition	inhibition	NOUN
dti-3271	69	18	of	of	ADP
dti-3271	69	19	selected	select	VERB
dti-3271	69	20	compounds	compound	NOUN
dti-3271	69	21	(	(	PUNCT
dti-3271	69	22	c1	c1	NOUN
dti-3271	69	23	-	-	PUNCT
dti-3271	69	24	c2	c2	PROPN
dti-3271	69	25	)	)	PUNCT
dti-3271	69	26	when	when	SCONJ
dti-3271	69	27	studied	study	VERB
dti-3271	69	28	at	at	ADP
dti-3271	69	29	various	various	ADJ
dti-3271	69	30	concentrations	concentration	NOUN
dti-3271	69	31	.	.	PUNCT
dti-3271	70	1	in	in	ADP
dti-3271	70	2	the	the	DET
dti-3271	70	3	assay	assay	NOUN
dti-3271	70	4	,	,	PUNCT
dti-3271	70	5	c1	c1	PROPN
dti-3271	70	6	produced	produce	VERB
dti-3271	70	7	marked	mark	VERB
dti-3271	70	8	inhibition	inhibition	NOUN
dti-3271	70	9	that	that	PRON
dti-3271	70	10	was	be	AUX
dti-3271	70	11	increased	increase	VERB
dti-3271	70	12	with	with	ADP
dti-3271	70	13	increasing	increase	VERB
dti-3271	70	14	drug	drug	NOUN
dti-3271	70	15	concentrations	concentration	NOUN
dti-3271	70	16	,	,	PUNCT
dti-3271	70	17	and	and	CCONJ
dti-3271	70	18	the	the	DET
dti-3271	70	19	maximum	maximum	ADJ
dti-3271	70	20	effect	effect	NOUN
dti-3271	70	21	(	(	PUNCT
dti-3271	70	22	88	88	NUM
dti-3271	70	23	%	%	NOUN
dti-3271	70	24	)	)	PUNCT
dti-3271	70	25	was	be	AUX
dti-3271	70	26	noted	note	VERB
dti-3271	70	27	at	at	ADP
dti-3271	70	28	1000	1000	NUM
dti-3271	70	29	μm	μm	NOUN
dti-3271	70	30	.	.	PUNCT
dti-3271	71	1	the	the	DET
dti-3271	71	2	ic50	ic50	PROPN
dti-3271	71	3	value	value	NOUN
dti-3271	71	4	of	of	ADP
dti-3271	71	5	c1	c1	PROPN
dti-3271	71	6	was	be	AUX
dti-3271	71	7	estimated	estimate	VERB
dti-3271	71	8	as	as	ADP
dti-3271	71	9	35.266	35.266	NUM
dti-3271	71	10	μm	μm	NOUN
dti-3271	71	11	.	.	PUNCT
dti-3271	72	1	similarly	similarly	ADV
dti-3271	72	2	,	,	PUNCT
dti-3271	72	3	c2	c2	PROPN
dti-3271	72	4	displayed	display	VERB
dti-3271	72	5	significant	significant	ADJ
dti-3271	72	6	α	α	ADJ
dti-3271	72	7	-	-	ADJ
dti-3271	72	8	glucosidase	glucosidase	ADJ
dti-3271	72	9	inhibition	inhibition	NOUN
dti-3271	72	10	when	when	SCONJ
dti-3271	72	11	tested	test	VERB
dti-3271	72	12	at	at	ADP
dti-3271	72	13	various	various	ADJ
dti-3271	72	14	concentrations	concentration	NOUN
dti-3271	72	15	.	.	PUNCT
dti-3271	73	1	the	the	DET
dti-3271	73	2	maximum	maximum	ADJ
dti-3271	73	3	inhibitory	inhibitory	ADJ
dti-3271	73	4	effect	effect	NOUN
dti-3271	73	5	was	be	AUX
dti-3271	73	6	85	85	NUM
dti-3271	73	7	%	%	NOUN
dti-3271	73	8	at	at	ADP
dti-3271	73	9	a	a	DET
dti-3271	73	10	dose	dose	NOUN
dti-3271	73	11	of	of	ADP
dti-3271	73	12	1000	1000	NUM
dti-3271	73	13	μm	μm	NOUN
dti-3271	73	14	in	in	ADP
dti-3271	73	15	specified	specified	ADJ
dti-3271	73	16	conditions	condition	NOUN
dti-3271	73	17	.	.	PUNCT
dti-3271	74	1	the	the	DET
dti-3271	74	2	potency	potency	NOUN
dti-3271	74	3	was	be	AUX
dti-3271	74	4	expressed	express	VERB
dti-3271	74	5	as	as	ADP
dti-3271	74	6	an	an	DET
dti-3271	74	7	ic50	ic50	PROPN
dti-3271	74	8	value	value	NOUN
dti-3271	74	9	of	of	ADP
dti-3271	74	10	38.379	38.379	NUM
dti-3271	74	11	μm	μm	NOUN
dti-3271	74	12	.	.	PUNCT
dti-3271	75	1	in	in	ADP
dti-3271	75	2	comparison	comparison	NOUN
dti-3271	75	3	,	,	PUNCT
dti-3271	75	4	acarbose	acarbose	PROPN
dti-3271	75	5	had	have	VERB
dti-3271	75	6	ic50	ic50	PROPN
dti-3271	75	7	values	value	NOUN
dti-3271	75	8	of	of	ADP
dti-3271	75	9	34.216	34.216	NUM
dti-3271	75	10	μm	μm	NOUN
dti-3271	75	11	.	.	PUNCT
dti-3271	75	12	effect	effect	NOUN
dti-3271	75	13	of	of	ADP
dti-3271	75	14	compounds	compound	NOUN
dti-3271	75	15	on	on	ADP
dti-3271	75	16	α	α	NOUN
dti-3271	75	17	-	-	PUNCT
dti-3271	75	18	amylase	amylase	NOUN
dti-3271	75	19	inhibition	inhibition	NOUN
dti-3271	75	20	the	the	DET
dti-3271	75	21	α	α	NOUN
dti-3271	75	22	-	-	PUNCT
dti-3271	75	23	amylase	amylase	NOUN
dti-3271	75	24	inhibitory	inhibitory	ADJ
dti-3271	75	25	potential	potential	NOUN
dti-3271	75	26	of	of	ADP
dti-3271	75	27	test	test	NOUN
dti-3271	75	28	compounds	compound	NOUN
dti-3271	75	29	(	(	PUNCT
dti-3271	75	30	c1	c1	NOUN
dti-3271	75	31	-	-	PUNCT
dti-3271	75	32	c2	c2	PROPN
dti-3271	75	33	)	)	PUNCT
dti-3271	75	34	when	when	SCONJ
dti-3271	75	35	challenged	challenge	VERB
dti-3271	75	36	at	at	ADP
dti-3271	75	37	various	various	ADJ
dti-3271	75	38	concentrations	concentration	NOUN
dti-3271	75	39	are	be	AUX
dti-3271	75	40	displayed	display	VERB
dti-3271	75	41	in	in	ADP
dti-3271	75	42	figure	figure	NOUN
dti-3271	75	43	3	3	NUM
dti-3271	75	44	.	.	PUNCT
dti-3271	76	1	compound	compound	NOUN
dti-3271	76	2	1	1	NUM
dti-3271	76	3	caused	cause	VERB
dti-3271	76	4	significant	significant	ADJ
dti-3271	76	5	inhibition	inhibition	NOUN
dti-3271	76	6	of	of	ADP
dti-3271	76	7	α	α	NOUN
dti-3271	76	8	-	-	NOUN
dti-3271	76	9	amylase	amylase	NOUN
dti-3271	76	10	,	,	PUNCT
dti-3271	76	11	and	and	CCONJ
dti-3271	76	12	the	the	DET
dti-3271	76	13	overall	overall	ADJ
dti-3271	76	14	effects	effect	NOUN
dti-3271	76	15	were	be	AUX
dti-3271	76	16	concentration	concentration	NOUN
dti-3271	76	17	dependant	dependant	ADJ
dti-3271	76	18	.	.	PUNCT
dti-3271	77	1	the	the	DET
dti-3271	77	2	maximum	maximum	ADJ
dti-3271	77	3	inhibition	inhibition	NOUN
dti-3271	77	4	of	of	ADP
dti-3271	77	5	90	90	NUM
dti-3271	77	6	%	%	NOUN
dti-3271	77	7	was	be	AUX
dti-3271	77	8	observed	observe	VERB
dti-3271	77	9	at	at	ADP
dti-3271	77	10	figure	figure	NOUN
dti-3271	77	11	2	2	NUM
dti-3271	77	12	showing	show	VERB
dti-3271	77	13	α	α	NOUN
dti-3271	77	14	-	-	ADJ
dti-3271	77	15	glucosidase	glucosidase	ADJ
dti-3271	77	16	inhibiting	inhibiting	ADJ
dti-3271	77	17	effects	effect	NOUN
dti-3271	77	18	of	of	ADP
dti-3271	77	19	compounds	compound	NOUN
dti-3271	77	20	(	(	PUNCT
dti-3271	77	21	c1	c1	NOUN
dti-3271	77	22	and	and	CCONJ
dti-3271	77	23	c2	c2	PROPN
dti-3271	77	24	)	)	PUNCT
dti-3271	77	25	.	.	PUNCT
dti-3271	78	1	the	the	DET
dti-3271	78	2	mean	mean	ADJ
dti-3271	78	3	±	±	NUM
dti-3271	78	4	sem	sem	NOUN
dti-3271	78	5	of	of	ADP
dti-3271	78	6	three	three	NUM
dti-3271	78	7	distinct	distinct	ADJ
dti-3271	78	8	measurements	measurement	NOUN
dti-3271	78	9	was	be	AUX
dti-3271	78	10	provided	provide	VERB
dti-3271	78	11	as	as	ADP
dti-3271	78	12	the	the	DET
dti-3271	78	13	result	result	NOUN
dti-3271	78	14	.	.	PUNCT
dti-3271	79	1	anova	anova	PROPN
dti-3271	79	2	at	at	ADP
dti-3271	79	3	*	*	PUNCT
dti-3271	79	4	p	p	X
dti-3271	79	5	<	<	X
dti-3271	79	6	0.05	0.05	NUM
dti-3271	79	7	and	and	CCONJ
dti-3271	79	8	the	the	DET
dti-3271	79	9	bonferroni	bonferroni	NOUN
dti-3271	79	10	test	test	NOUN
dti-3271	79	11	showed	show	VERB
dti-3271	79	12	static	static	ADJ
dti-3271	79	13	significance	significance	NOUN
dti-3271	79	14	.	.	PUNCT
dti-3271	80	1	at	at	ADP
dti-3271	80	2	the	the	DET
dti-3271	80	3	same	same	ADJ
dti-3271	80	4	tested	test	VERB
dti-3271	80	5	strengths	strength	NOUN
dti-3271	80	6	,	,	PUNCT
dti-3271	80	7	there	there	PRON
dti-3271	80	8	are	be	VERB
dti-3271	80	9	slight	slight	ADJ
dti-3271	80	10	variations	variation	NOUN
dti-3271	80	11	in	in	ADP
dti-3271	80	12	*	*	PROPN
dti-3271	80	13	*	*	PUNCT
dti-3271	80	14	*	*	PUNCT
dti-3271	80	15	p	p	X
dti-3271	80	16	<	<	X
dti-3271	80	17	0.001	0.001	NUM
dti-3271	80	18	results	result	NOUN
dti-3271	80	19	when	when	SCONJ
dti-3271	80	20	compared	compare	VERB
dti-3271	80	21	to	to	ADP
dti-3271	80	22	the	the	DET
dti-3271	80	23	positive	positive	ADJ
dti-3271	80	24	control	control	NOUN
dti-3271	80	25	(	(	PUNCT
dti-3271	80	26	acarbose	acarbose	NOUN
dti-3271	80	27	)	)	PUNCT
dti-3271	80	28	.	.	PUNCT
dti-3271	81	1	figure	figure	VERB
dti-3271	81	2	3	3	NUM
dti-3271	81	3	showing	show	VERB
dti-3271	81	4	α	α	NOUN
dti-3271	81	5	-	-	PUNCT
dti-3271	81	6	amylase	amylase	NOUN
dti-3271	81	7	inhibiting	inhibit	VERB
dti-3271	81	8	effects	effect	NOUN
dti-3271	81	9	of	of	ADP
dti-3271	81	10	compounds	compound	NOUN
dti-3271	81	11	(	(	PUNCT
dti-3271	81	12	c1	c1	NOUN
dti-3271	81	13	and	and	CCONJ
dti-3271	81	14	c2	c2	PROPN
dti-3271	81	15	)	)	PUNCT
dti-3271	81	16	.	.	PUNCT
dti-3271	82	1	the	the	DET
dti-3271	82	2	mean	mean	ADJ
dti-3271	82	3	±	±	NUM
dti-3271	82	4	sem	sem	NOUN
dti-3271	82	5	of	of	ADP
dti-3271	82	6	three	three	NUM
dti-3271	82	7	distinct	distinct	ADJ
dti-3271	82	8	measurements	measurement	NOUN
dti-3271	82	9	was	be	AUX
dti-3271	82	10	provided	provide	VERB
dti-3271	82	11	as	as	ADP
dti-3271	82	12	the	the	DET
dti-3271	82	13	result	result	NOUN
dti-3271	82	14	.	.	PUNCT
dti-3271	83	1	anova	anova	PROPN
dti-3271	83	2	at	at	ADP
dti-3271	83	3	*	*	PUNCT
dti-3271	83	4	p	p	X
dti-3271	83	5	<	<	X
dti-3271	83	6	0.05	0.05	NUM
dti-3271	83	7	and	and	CCONJ
dti-3271	83	8	the	the	DET
dti-3271	83	9	bonferroni	bonferroni	NOUN
dti-3271	83	10	test	test	NOUN
dti-3271	83	11	showed	show	VERB
dti-3271	83	12	static	static	ADJ
dti-3271	83	13	significance	significance	NOUN
dti-3271	83	14	.	.	PUNCT
dti-3271	84	1	at	at	ADP
dti-3271	84	2	the	the	DET
dti-3271	84	3	same	same	ADJ
dti-3271	84	4	tested	test	VERB
dti-3271	84	5	strengths	strength	NOUN
dti-3271	84	6	,	,	PUNCT
dti-3271	84	7	there	there	PRON
dti-3271	84	8	are	be	VERB
dti-3271	84	9	slight	slight	ADJ
dti-3271	84	10	variations	variation	NOUN
dti-3271	84	11	in	in	ADP
dti-3271	84	12	*	*	PROPN
dti-3271	84	13	*	*	PUNCT
dti-3271	84	14	*	*	PUNCT
dti-3271	84	15	p	p	X
dti-3271	84	16	<	<	X
dti-3271	84	17	0.001	0.001	NUM
dti-3271	84	18	results	result	NOUN
dti-3271	84	19	when	when	SCONJ
dti-3271	84	20	compared	compare	VERB
dti-3271	84	21	to	to	ADP
dti-3271	84	22	the	the	DET
dti-3271	84	23	positive	positive	ADJ
dti-3271	84	24	control	control	NOUN
dti-3271	84	25	(	(	PUNCT
dti-3271	84	26	acarbose	acarbose	NOUN
dti-3271	84	27	)	)	PUNCT
dti-3271	84	28	.	.	PUNCT
dti-3271	85	1	anti	anti	ADJ
dti-3271	85	2	-	-	ADJ
dti-3271	85	3	diabetic	diabetic	ADJ
dti-3271	85	4	effects	effect	NOUN
dti-3271	85	5	of	of	ADP
dti-3271	85	6	dichloroindolinone14	dichloroindolinone14	NOUN
dti-3271	85	7	©	©	PROPN
dti-3271	85	8	2025	2025	NUM
dti-3271	85	9	the	the	DET
dti-3271	85	10	authors	author	NOUN
dti-3271	85	11	.	.	PUNCT
dti-3271	86	1	drug	drug	NOUN
dti-3271	86	2	target	target	NOUN
dti-3271	86	3	insights	insight	NOUN
dti-3271	86	4	issn	issn	VERB
dti-3271	86	5	1177	1177	NUM
dti-3271	86	6	-	-	SYM
dti-3271	86	7	3928	3928	NUM
dti-3271	86	8	www.aboutscience.eu/dti	www.aboutscience.eu/dti	VERB
dti-3271	86	9	1000	1000	NUM
dti-3271	86	10	μm	μm	NOUN
dti-3271	86	11	,	,	PUNCT
dti-3271	86	12	and	and	CCONJ
dti-3271	86	13	the	the	DET
dti-3271	86	14	ic50	ic50	PROPN
dti-3271	86	15	was	be	AUX
dti-3271	86	16	42.449	42.449	NUM
dti-3271	86	17	μm	μm	NOUN
dti-3271	86	18	.	.	PUNCT
dti-3271	87	1	similarly	similarly	ADV
dti-3271	87	2	,	,	PUNCT
dti-3271	87	3	compound	compound	NOUN
dti-3271	87	4	2	2	NUM
dti-3271	87	5	caused	cause	VERB
dti-3271	87	6	potential	potential	ADJ
dti-3271	87	7	α	α	NOUN
dti-3271	87	8	-	-	PUNCT
dti-3271	87	9	amylase	amylase	NOUN
dti-3271	87	10	inhibition	inhibition	NOUN
dti-3271	87	11	at	at	ADP
dti-3271	87	12	various	various	ADJ
dti-3271	87	13	doses	dose	NOUN
dti-3271	87	14	from	from	ADP
dti-3271	87	15	62.50	62.50	NUM
dti-3271	87	16	-	-	SYM
dti-3271	87	17	1000	1000	NUM
dti-3271	87	18	μm	μm	NOUN
dti-3271	87	19	.	.	PUNCT
dti-3271	88	1	the	the	DET
dti-3271	88	2	maximum	maximum	ADJ
dti-3271	88	3	inhibition	inhibition	NOUN
dti-3271	88	4	,	,	PUNCT
dti-3271	88	5	87	87	NUM
dti-3271	88	6	%	%	NOUN
dti-3271	88	7	,	,	PUNCT
dti-3271	88	8	was	be	AUX
dti-3271	88	9	demonstrated	demonstrate	VERB
dti-3271	88	10	at	at	ADP
dti-3271	88	11	1000	1000	NUM
dti-3271	88	12	μm	μm	NOUN
dti-3271	88	13	.	.	PUNCT
dti-3271	89	1	the	the	DET
dti-3271	89	2	overall	overall	ADJ
dti-3271	89	3	effect	effect	NOUN
dti-3271	89	4	of	of	ADP
dti-3271	89	5	ic50	ic50	PROPN
dti-3271	89	6	was	be	AUX
dti-3271	89	7	46.708	46.708	NUM
dti-3271	89	8	μm	μm	NOUN
dti-3271	89	9	.	.	PUNCT
dti-3271	90	1	the	the	DET
dti-3271	90	2	standard	standard	ADJ
dti-3271	90	3	drug	drug	NOUN
dti-3271	90	4	(	(	PUNCT
dti-3271	90	5	acarbose	acarbose	NOUN
dti-3271	90	6	)	)	PUNCT
dti-3271	90	7	had	have	VERB
dti-3271	90	8	an	an	DET
dti-3271	90	9	ic50	ic50	PROPN
dti-3271	90	10	value	value	NOUN
dti-3271	90	11	of	of	ADP
dti-3271	90	12	24.802	24.802	NUM
dti-3271	90	13	μm	μm	NOUN
dti-3271	90	14	.	.	PUNCT
dti-3271	91	1	molecular	molecular	ADJ
dti-3271	91	2	docking	docking	NOUN
dti-3271	91	3	analysis	analysis	NOUN
dti-3271	91	4	the	the	DET
dti-3271	91	5	binding	bind	VERB
dti-3271	91	6	free	free	ADJ
dti-3271	91	7	energies	energy	NOUN
dti-3271	91	8	for	for	ADP
dti-3271	91	9	δe	δe	NOUN
dti-3271	91	10	are	be	AUX
dti-3271	91	11	listed	list	VERB
dti-3271	91	12	in	in	ADP
dti-3271	91	13	(	(	PUNCT
dti-3271	91	14	table	table	NOUN
dti-3271	91	15	1	1	NUM
dti-3271	91	16	)	)	PUNCT
dti-3271	91	17	.	.	PUNCT
dti-3271	92	1	the	the	DET
dti-3271	92	2	initial	initial	ADJ
dti-3271	92	3	inhibitors	inhibitor	NOUN
dti-3271	92	4	have	have	AUX
dti-3271	92	5	been	be	AUX
dti-3271	92	6	adequately	adequately	ADV
dti-3271	92	7	installed	instal	VERB
dti-3271	92	8	into	into	ADP
dti-3271	92	9	their	their	PRON
dti-3271	92	10	binding	bind	VERB
dti-3271	92	11	sites	site	NOUN
dti-3271	92	12	in	in	ADP
dti-3271	92	13	order	order	NOUN
dti-3271	92	14	to	to	PART
dti-3271	92	15	attain	attain	VERB
dti-3271	92	16	their	their	PRON
dti-3271	92	17	crystal	crystal	NOUN
dti-3271	92	18	configurations	configuration	NOUN
dti-3271	92	19	.	.	PUNCT
dti-3271	93	1	table	table	NOUN
dti-3271	93	2	1	1	NUM
dti-3271	93	3	the	the	DET
dti-3271	93	4	binding	bind	VERB
dti-3271	93	5	affinity	affinity	NOUN
dti-3271	93	6	for	for	ADP
dti-3271	93	7	compounds	compound	NOUN
dti-3271	93	8	c1	c1	PROPN
dti-3271	93	9	and	and	CCONJ
dti-3271	93	10	c2	c2	PROPN
dti-3271	93	11	with	with	ADP
dti-3271	93	12	docking	dock	VERB
dti-3271	93	13	score	score	NOUN
dti-3271	93	14	(	(	PUNCT
dti-3271	93	15	kcal	kcal	NOUN
dti-3271	93	16	/	/	SYM
dti-3271	93	17	mol	mol	NOUN
dti-3271	93	18	)	)	PUNCT
dti-3271	93	19	against	against	ADP
dti-3271	93	20	α	α	NOUN
dti-3271	93	21	-	-	PUNCT
dti-3271	93	22	amylase	amylase	NOUN
dti-3271	93	23	no	no	NOUN
dti-3271	93	24	.	.	PUNCT
dti-3271	94	1	δg	δg	AUX
dti-3271	94	2	rmsd	rmsd	VERB
dti-3271	94	3	h.	h.	PROPN
dti-3271	94	4	b	b	PROPN
dti-3271	94	5	eint	eint	PROPN
dti-3271	94	6	.	.	PUNCT
dti-3271	95	1	eele	eele	PROPN
dti-3271	95	2	le	le	PUNCT
dti-3271	96	1	α	α	PROPN
dti-3271	96	2	-	-	PUNCT
dti-3271	96	3	glucosides	glucoside	NOUN
dti-3271	96	4	c1	c1	NOUN
dti-3271	96	5	−5.898	−5.898	PROPN
dti-3271	96	6	0.893	0.893	NUM
dti-3271	96	7	−10.228	−10.228	PROPN
dti-3271	96	8	−6.188	−6.188	PROPN
dti-3271	96	9	−13.702	−13.702	NOUN
dti-3271	96	10	−6.604	−6.604	PROPN
dti-3271	96	11	c2	c2	PROPN
dti-3271	96	12	−6.312	−6.312	VERB
dti-3271	96	13	1.285	1.285	NUM
dti-3271	96	14	−8.658	−8.658	PROPN
dti-3271	96	15	−4.223	−4.223	PROPN
dti-3271	96	16	−21.775	−21.775	NOUN
dti-3271	96	17	−4.912	−4.912	PROPN
dti-3271	96	18	acarbose	acarbose	NOUN
dti-3271	97	1	−6.088	−6.088	NOUN
dti-3271	97	2	0.725	0.725	NUM
dti-3271	97	3	−15.129	−15.129	PROPN
dti-3271	97	4	−12.148	−12.148	NOUN
dti-3271	97	5	−31.340	−31.340	VERB
dti-3271	97	6	−8.393	−8.393	NUM
dti-3271	97	7	α	α	NOUN
dti-3271	97	8	-	-	PUNCT
dti-3271	97	9	amylase	amylase	NOUN
dti-3271	97	10	c1	c1	NOUN
dti-3271	97	11	−5.449	−5.449	NOUN
dti-3271	97	12	0.955	0.955	NUM
dti-3271	97	13	24.364	24.364	NUM
dti-3271	97	14	−19.256	−19.256	ADJ
dti-3271	97	15	−8.526	−8.526	NOUN
dti-3271	97	16	2.10	2.10	NUM
dti-3271	97	17	c2	c2	PROPN
dti-3271	97	18	−5.497	−5.497	NOUN
dti-3271	97	19	1.257	1.257	NUM
dti-3271	97	20	19.021	19.021	NUM
dti-3271	97	21	−18.133	−18.133	NOUN
dti-3271	97	22	−8.679	−8.679	PRON
dti-3271	97	23	2.253	2.253	NUM
dti-3271	97	24	acarbose	acarbose	NOUN
dti-3271	97	25	−9.814	−9.814	PROPN
dti-3271	97	26	1.634	1.634	NUM
dti-3271	97	27	-34.746	-34.746	PROPN
dti-3271	97	28	−15.117	−15.117	PROPN
dti-3271	97	29	−55.322	−55.322	PROPN
dti-3271	97	30	2.885	2.885	NUM
dti-3271	97	31	where	where	SCONJ
dti-3271	97	32	δg	δg	VERB
dti-3271	97	33	:	:	PUNCT
dti-3271	97	34	free	free	ADJ
dti-3271	97	35	binding	bind	VERB
dti-3271	97	36	energy	energy	NOUN
dti-3271	97	37	of	of	ADP
dti-3271	97	38	the	the	DET
dti-3271	97	39	ligand	ligand	NOUN
dti-3271	97	40	;	;	PUNCT
dti-3271	97	41	rmsd	rmsd	VERB
dti-3271	97	42	:	:	PUNCT
dti-3271	97	43	root	root	NOUN
dti-3271	97	44	-	-	PUNCT
dti-3271	97	45	mean	mean	ADJ
dti-3271	97	46	-	-	PUNCT
dti-3271	97	47	square	square	NOUN
dti-3271	97	48	deviation	deviation	NOUN
dti-3271	97	49	;	;	PUNCT
dti-3271	97	50	h.b	h.b	PROPN
dti-3271	97	51	.	.	PROPN
dti-3271	97	52	:	:	PUNCT
dti-3271	98	1	h	h	NOUN
dti-3271	98	2	-	-	PUNCT
dti-3271	98	3	bonding	bond	VERB
dti-3271	98	4	energy	energy	NOUN
dti-3271	98	5	between	between	ADP
dti-3271	98	6	protein	protein	NOUN
dti-3271	98	7	and	and	CCONJ
dti-3271	98	8	ligand	ligand	NOUN
dti-3271	98	9	;	;	PUNCT
dti-3271	98	10	eint	eint	NOUN
dti-3271	98	11	.	.	PUNCT
dti-3271	99	1	binding	bind	VERB
dti-3271	99	2	affinity	affinity	NOUN
dti-3271	99	3	of	of	ADP
dti-3271	99	4	h	h	NOUN
dti-3271	99	5	-	-	PUNCT
dti-3271	99	6	bond	bond	NOUN
dti-3271	99	7	interaction	interaction	NOUN
dti-3271	99	8	with	with	ADP
dti-3271	99	9	receptor	receptor	NOUN
dti-3271	99	10	;	;	PUNCT
dti-3271	99	11	eele	eele	PROPN
dti-3271	99	12	:	:	PUNCT
dti-3271	99	13	electrostatic	electrostatic	ADJ
dti-3271	99	14	interaction	interaction	NOUN
dti-3271	99	15	over	over	ADP
dti-3271	99	16	the	the	DET
dti-3271	99	17	receptor	receptor	NOUN
dti-3271	99	18	,	,	PUNCT
dti-3271	99	19	ki	ki	PROPN
dti-3271	99	20	:	:	PUNCT
dti-3271	99	21	inhibition	inhibition	NOUN
dti-3271	99	22	constant	constant	ADJ
dti-3271	99	23	.	.	PUNCT
dti-3271	100	1	for	for	ADP
dti-3271	100	2	the	the	DET
dti-3271	100	3	docking	docking	NOUN
dti-3271	100	4	analysis	analysis	NOUN
dti-3271	100	5	,	,	PUNCT
dti-3271	100	6	we	we	PRON
dti-3271	100	7	selected	select	VERB
dti-3271	100	8	the	the	DET
dti-3271	100	9	most	most	ADV
dti-3271	100	10	perforable	perforable	ADJ
dti-3271	100	11	docking	docking	NOUN
dti-3271	100	12	conformations	conformation	NOUN
dti-3271	100	13	of	of	ADP
dti-3271	100	14	c1	c1	PROPN
dti-3271	100	15	and	and	CCONJ
dti-3271	100	16	c2	c2	PROPN
dti-3271	100	17	compounds	compound	VERB
dti-3271	100	18	that	that	PRON
dti-3271	100	19	were	be	AUX
dti-3271	100	20	detected	detect	VERB
dti-3271	100	21	inside	inside	ADP
dti-3271	100	22	the	the	DET
dti-3271	100	23	active	active	ADJ
dti-3271	100	24	site	site	NOUN
dti-3271	100	25	of	of	ADP
dti-3271	100	26	α	α	NOUN
dti-3271	100	27	-	-	PUNCT
dti-3271	100	28	glucosidase	glucosidase	ADJ
dti-3271	100	29	enzyme	enzyme	NOUN
dti-3271	100	30	(	(	PUNCT
dti-3271	100	31	pdb	pdb	NOUN
dti-3271	100	32	:	:	PUNCT
dti-3271	100	33	3a4a	3a4a	NUM
dti-3271	100	34	)	)	PUNCT
dti-3271	100	35	with	with	ADP
dti-3271	100	36	proper	proper	ADJ
dti-3271	100	37	alignment	alignment	NOUN
dti-3271	100	38	.	.	PUNCT
dti-3271	101	1	the	the	DET
dti-3271	101	2	active	active	ADJ
dti-3271	101	3	site	site	NOUN
dti-3271	101	4	includes	include	VERB
dti-3271	101	5	the	the	DET
dti-3271	101	6	hydrophilic	hydrophilic	ADJ
dti-3271	101	7	amino	amino	NOUN
dti-3271	101	8	acids	acid	NOUN
dti-3271	101	9	(	(	PUNCT
dti-3271	101	10	asp69	asp69	PROPN
dti-3271	101	11	,	,	PUNCT
dti-3271	101	12	tyr72	tyr72	PROPN
dti-3271	101	13	,	,	PUNCT
dti-3271	101	14	glu277	glu277	PROPN
dti-3271	101	15	,	,	PUNCT
dti-3271	101	16	his351	his351	NOUN
dti-3271	101	17	,	,	PUNCT
dti-3271	101	18	asp352	asp352	NOUN
dti-3271	101	19	,	,	PUNCT
dti-3271	101	20	and	and	CCONJ
dti-3271	101	21	arg442	arg442	PROPN
dti-3271	101	22	)	)	PUNCT
dti-3271	101	23	,	,	PUNCT
dti-3271	101	24	which	which	PRON
dti-3271	101	25	interact	interact	VERB
dti-3271	101	26	with	with	ADP
dti-3271	101	27	competitive	competitive	ADJ
dti-3271	101	28	inhibitor	inhibitor	NOUN
dti-3271	101	29	acarbose	acarbose	NOUN
dti-3271	101	30	.	.	PUNCT
dti-3271	102	1	we	we	PRON
dti-3271	102	2	noticed	notice	VERB
dti-3271	102	3	that	that	SCONJ
dti-3271	102	4	almost	almost	ADV
dti-3271	102	5	all	all	PRON
dti-3271	102	6	investigated	investigate	VERB
dti-3271	102	7	compounds	compound	NOUN
dti-3271	102	8	interacted	interact	VERB
dti-3271	102	9	with	with	ADP
dti-3271	102	10	significant	significant	ADJ
dti-3271	102	11	residues	residue	NOUN
dti-3271	102	12	in	in	ADP
dti-3271	102	13	the	the	DET
dti-3271	102	14	binding	bind	VERB
dti-3271	102	15	pocket	pocket	NOUN
dti-3271	102	16	.	.	PUNCT
dti-3271	103	1	we	we	PRON
dti-3271	103	2	defined	define	VERB
dti-3271	103	3	the	the	DET
dti-3271	103	4	inhibitory	inhibitory	ADJ
dti-3271	103	5	behavior	behavior	NOUN
dti-3271	103	6	in	in	ADP
dti-3271	103	7	terms	term	NOUN
dti-3271	103	8	of	of	ADP
dti-3271	103	9	binding	bind	VERB
dti-3271	103	10	energy	energy	NOUN
dti-3271	103	11	be	be	VERB
dti-3271	103	12	that	that	PRON
dti-3271	103	13	was	be	AUX
dti-3271	103	14	evaluated	evaluate	VERB
dti-3271	103	15	with	with	ADP
dti-3271	103	16	the	the	DET
dti-3271	103	17	receptor	receptor	NOUN
dti-3271	103	18	.	.	PUNCT
dti-3271	104	1	then	then	ADV
dti-3271	104	2	,	,	PUNCT
dti-3271	104	3	redocked	redocke	VERB
dti-3271	104	4	compounds	compound	NOUN
dti-3271	104	5	compared	compare	VERB
dti-3271	104	6	the	the	DET
dti-3271	104	7	results	result	NOUN
dti-3271	104	8	to	to	ADP
dti-3271	104	9	the	the	DET
dti-3271	104	10	comparative	comparative	ADJ
dti-3271	104	11	reference	reference	NOUN
dti-3271	104	12	inhibitor	inhibitor	NOUN
dti-3271	104	13	and	and	CCONJ
dti-3271	104	14	obtained	obtain	VERB
dti-3271	104	15	a	a	DET
dti-3271	104	16	root	root	NOUN
dti-3271	104	17	mean	mean	ADJ
dti-3271	104	18	square	square	ADJ
dti-3271	104	19	deviation	deviation	NOUN
dti-3271	104	20	(	(	PUNCT
dti-3271	104	21	rmsd	rmsd	NOUN
dti-3271	104	22	)	)	PUNCT
dti-3271	104	23	,	,	PUNCT
dti-3271	104	24	which	which	PRON
dti-3271	104	25	is	be	AUX
dti-3271	104	26	summarized	summarize	VERB
dti-3271	104	27	in	in	ADP
dti-3271	104	28	(	(	PUNCT
dti-3271	104	29	table	table	NOUN
dti-3271	104	30	1	1	NUM
dti-3271	104	31	)	)	PUNCT
dti-3271	104	32	.	.	PUNCT
dti-3271	105	1	the	the	DET
dti-3271	105	2	c2	c2	PROPN
dti-3271	105	3	exhibited	exhibit	VERB
dti-3271	105	4	strong	strong	ADJ
dti-3271	105	5	interactions	interaction	NOUN
dti-3271	105	6	with	with	ADP
dti-3271	105	7	the	the	DET
dti-3271	105	8	enzyme	enzyme	NOUN
dti-3271	105	9	,	,	PUNCT
dti-3271	105	10	as	as	SCONJ
dti-3271	105	11	indicated	indicate	VERB
dti-3271	105	12	by	by	ADP
dti-3271	105	13	their	their	PRON
dti-3271	105	14	binding	bind	VERB
dti-3271	105	15	free	free	ADJ
dti-3271	105	16	energies	energy	NOUN
dti-3271	105	17	of	of	ADP
dti-3271	105	18	−6.312	−6.312	PROPN
dti-3271	105	19	kcal	kcal	PROPN
dti-3271	105	20	/	/	SYM
dti-3271	105	21	mol	mol	PROPN
dti-3271	105	22	.	.	PUNCT
dti-3271	106	1	compared	compare	VERB
dti-3271	106	2	to	to	ADP
dti-3271	106	3	the	the	DET
dti-3271	106	4	reference	reference	NOUN
dti-3271	106	5	inhibitor	inhibitor	NOUN
dti-3271	106	6	,	,	PUNCT
dti-3271	106	7	which	which	PRON
dti-3271	106	8	had	have	VERB
dti-3271	106	9	a	a	DET
dti-3271	106	10	binding	bind	VERB
dti-3271	106	11	free	free	ADJ
dti-3271	106	12	energy	energy	NOUN
dti-3271	106	13	of	of	ADP
dti-3271	106	14	−6.088	−6.088	PROPN
dti-3271	106	15	kcal	kcal	PROPN
dti-3271	106	16	/	/	SYM
dti-3271	106	17	mol	mol	PROPN
dti-3271	106	18	and	and	CCONJ
dti-3271	106	19	lower	low	ADJ
dti-3271	106	20	inhibitory	inhibitory	ADJ
dti-3271	106	21	activity	activity	NOUN
dti-3271	106	22	,	,	PUNCT
dti-3271	106	23	the	the	DET
dti-3271	106	24	c1	c1	NOUN
dti-3271	106	25	showed	show	VERB
dti-3271	106	26	superior	superior	ADJ
dti-3271	106	27	binding	bind	VERB
dti-3271	106	28	efficacies	efficacy	NOUN
dti-3271	106	29	,	,	PUNCT
dti-3271	106	30	−5.898	−5.898	PROPN
dti-3271	106	31	kcal	kcal	PROPN
dti-3271	106	32	/	/	SYM
dti-3271	106	33	mol	mol	PROPN
dti-3271	106	34	.	.	PUNCT
dti-3271	107	1	the	the	DET
dti-3271	107	2	docking	docking	NOUN
dti-3271	107	3	analysis	analysis	NOUN
dti-3271	107	4	revealed	reveal	VERB
dti-3271	107	5	that	that	SCONJ
dti-3271	107	6	c2	c2	PROPN
dti-3271	107	7	had	have	VERB
dti-3271	107	8	the	the	DET
dti-3271	107	9	highest	high	ADJ
dti-3271	107	10	binding	bind	VERB
dti-3271	107	11	affinity	affinity	NOUN
dti-3271	107	12	and	and	CCONJ
dti-3271	107	13	formed	form	VERB
dti-3271	107	14	a	a	DET
dti-3271	107	15	strong	strong	ADJ
dti-3271	107	16	hydrogen	hydrogen	NOUN
dti-3271	107	17	bond	bond	NOUN
dti-3271	107	18	with	with	ADP
dti-3271	107	19	gly353	gly353	PROPN
dti-3271	107	20	,	,	PUNCT
dti-3271	107	21	glu411	glu411	NOUN
dti-3271	107	22	,	,	PUNCT
dti-3271	107	23	and	and	CCONJ
dti-3271	107	24	asp307	asp307	PROPN
dti-3271	107	25	,	,	PUNCT
dti-3271	107	26	which	which	PRON
dti-3271	107	27	are	be	AUX
dti-3271	107	28	essential	essential	ADJ
dti-3271	107	29	for	for	ADP
dti-3271	107	30	enzyme	enzyme	NOUN
dti-3271	107	31	activity	activity	NOUN
dti-3271	107	32	.	.	PUNCT
dti-3271	108	1	the	the	DET
dti-3271	108	2	second	second	ADJ
dti-3271	108	3	inhibitor	inhibitor	NOUN
dti-3271	108	4	,	,	PUNCT
dti-3271	108	5	c1	c1	PROPN
dti-3271	108	6	,	,	PUNCT
dti-3271	108	7	had	have	VERB
dti-3271	108	8	a	a	DET
dti-3271	108	9	similar	similar	ADJ
dti-3271	108	10	binding	bind	VERB
dti-3271	108	11	mode	mode	NOUN
dti-3271	108	12	to	to	ADP
dti-3271	108	13	the	the	DET
dti-3271	108	14	reference	reference	NOUN
dti-3271	108	15	inhibitor	inhibitor	NOUN
dti-3271	108	16	and	and	CCONJ
dti-3271	108	17	established	establish	VERB
dti-3271	108	18	a	a	DET
dti-3271	108	19	strong	strong	ADJ
dti-3271	108	20	hydrogen	hydrogen	NOUN
dti-3271	108	21	bond	bond	NOUN
dti-3271	108	22	with	with	ADP
dti-3271	108	23	gln353	gln353	PROPN
dti-3271	108	24	,	,	PUNCT
dti-3271	108	25	arg213	arg213	PROPN
dti-3271	108	26	,	,	PUNCT
dti-3271	108	27	and	and	CCONJ
dti-3271	108	28	gln182	gln182	PROPN
dti-3271	108	29	(	(	PUNCT
dti-3271	108	30	figure	figure	NOUN
dti-3271	108	31	4	4	NUM
dti-3271	108	32	)	)	PUNCT
dti-3271	108	33	.	.	PUNCT
dti-3271	109	1	the	the	DET
dti-3271	109	2	molecule	molecule	NOUN
dti-3271	109	3	docked	dock	VERB
dti-3271	109	4	prolifically	prolifically	ADV
dti-3271	109	5	into	into	ADP
dti-3271	109	6	active	active	ADJ
dti-3271	109	7	sites	site	NOUN
dti-3271	109	8	in	in	ADP
dti-3271	109	9	a	a	DET
dti-3271	109	10	mechanism	mechanism	NOUN
dti-3271	109	11	similar	similar	ADJ
dti-3271	109	12	to	to	ADP
dti-3271	109	13	that	that	PRON
dti-3271	109	14	of	of	ADP
dti-3271	109	15	the	the	DET
dti-3271	109	16	original	original	ADJ
dti-3271	109	17	inhibitors	inhibitor	NOUN
dti-3271	109	18	.	.	PUNCT
dti-3271	110	1	for	for	ADP
dti-3271	110	2	amylase	amylase	NOUN
dti-3271	110	3	,	,	PUNCT
dti-3271	110	4	compounds	compound	VERB
dti-3271	110	5	c1	c1	PROPN
dti-3271	110	6	and	and	CCONJ
dti-3271	110	7	c2	c2	PROPN
dti-3271	110	8	demonstrated	demonstrate	VERB
dti-3271	110	9	promising	promise	VERB
dti-3271	110	10	binding	bind	VERB
dti-3271	110	11	affinities	affinity	NOUN
dti-3271	110	12	(	(	PUNCT
dti-3271	110	13	δe	δe	NOUN
dti-3271	110	14	=	=	NOUN
dti-3271	110	15	−5.44	−5.44	NOUN
dti-3271	110	16	to	to	ADP
dti-3271	110	17	−5.5	−5.5	PROPN
dti-3271	110	18	kcal	kcal	NOUN
dti-3271	110	19	/	/	SYM
dti-3271	110	20	mol	mol	NOUN
dti-3271	110	21	)	)	PUNCT
dti-3271	110	22	,	,	PUNCT
dti-3271	110	23	which	which	PRON
dti-3271	110	24	substantiated	substantiate	VERB
dti-3271	110	25	their	their	PRON
dti-3271	110	26	promising	promising	ADJ
dti-3271	110	27	potencies	potency	NOUN
dti-3271	110	28	.	.	PUNCT
dti-3271	111	1	the	the	DET
dti-3271	111	2	interactions	interaction	NOUN
dti-3271	111	3	between	between	ADP
dti-3271	111	4	the	the	DET
dti-3271	111	5	thirteen	thirteen	NUM
dti-3271	111	6	active	active	ADJ
dti-3271	111	7	compounds	compound	NOUN
dti-3271	111	8	c1	c1	PROPN
dti-3271	111	9	and	and	CCONJ
dti-3271	111	10	c2	c2	PROPN
dti-3271	111	11	with	with	ADP
dti-3271	111	12	the	the	DET
dti-3271	111	13	active	active	ADJ
dti-3271	111	14	site	site	NOUN
dti-3271	111	15	residues	residue	NOUN
dti-3271	111	16	were	be	AUX
dti-3271	111	17	mainly	mainly	ADV
dti-3271	111	18	polar	polar	ADJ
dti-3271	111	19	bonds	bond	NOUN
dti-3271	111	20	,	,	PUNCT
dti-3271	111	21	hydrogen	hydrogen	NOUN
dti-3271	111	22	bonding	bonding	NOUN
dti-3271	111	23	,	,	PUNCT
dti-3271	111	24	π−π	π−π	PROPN
dti-3271	111	25	,	,	PUNCT
dti-3271	111	26	and	and	CCONJ
dti-3271	111	27	π−h	π−h	NOUN
dti-3271	111	28	interactions	interaction	NOUN
dti-3271	111	29	,	,	PUNCT
dti-3271	111	30	which	which	PRON
dti-3271	111	31	contributed	contribute	VERB
dti-3271	111	32	to	to	ADP
dti-3271	111	33	a	a	DET
dti-3271	111	34	strong	strong	ADJ
dti-3271	111	35	alignment	alignment	NOUN
dti-3271	111	36	with	with	ADP
dti-3271	111	37	the	the	DET
dti-3271	111	38	enzyme	enzyme	NOUN
dti-3271	111	39	backbone	backbone	NOUN
dti-3271	111	40	figure	figure	NOUN
dti-3271	111	41	5	5	NUM
dti-3271	111	42	.	.	PUNCT
dti-3271	112	1	the	the	DET
dti-3271	112	2	active	active	ADJ
dti-3271	112	3	molecules	molecule	NOUN
dti-3271	112	4	c1	c1	PROPN
dti-3271	112	5	and	and	CCONJ
dti-3271	112	6	c2	c2	PROPN
dti-3271	112	7	were	be	AUX
dti-3271	112	8	attached	attach	VERB
dti-3271	112	9	deeply	deeply	ADV
dti-3271	112	10	and	and	CCONJ
dti-3271	112	11	comfortingly	comfortingly	ADV
dti-3271	112	12	in	in	ADP
dti-3271	112	13	the	the	DET
dti-3271	112	14	binding	bind	VERB
dti-3271	112	15	pocket	pocket	NOUN
dti-3271	112	16	by	by	ADP
dti-3271	112	17	interacting	interact	VERB
dti-3271	112	18	with	with	ADP
dti-3271	112	19	the	the	DET
dti-3271	112	20	hydrophilic	hydrophilic	ADJ
dti-3271	112	21	asp	asp	NOUN
dti-3271	112	22	198	198	NUM
dti-3271	112	23	hydrophobic	hydrophobic	NOUN
dti-3271	112	24	binding	bind	VERB
dti-3271	112	25	pocket	pocket	NOUN
dti-3271	112	26	ala197	ala197	NOUN
dti-3271	113	1	and	and	CCONJ
dti-3271	113	2	ile	ile	PROPN
dti-3271	113	3	235	235	NUM
dti-3271	113	4	.	.	PUNCT
dti-3271	114	1	compound	compound	NOUN
dti-3271	114	2	c2	c2	PROPN
dti-3271	114	3	docked	dock	VERB
dti-3271	114	4	in	in	ADP
dti-3271	114	5	the	the	DET
dti-3271	114	6	α	α	NOUN
dti-3271	114	7	-	-	PUNCT
dti-3271	114	8	amylase	amylase	NOUN
dti-3271	114	9	binding	bind	VERB
dti-3271	114	10	pocket	pocket	NOUN
dti-3271	114	11	via	via	ADP
dti-3271	114	12	hydrophobic	hydrophobic	NOUN
dti-3271	114	13	interaction	interaction	NOUN
dti-3271	114	14	with	with	ADP
dti-3271	114	15	ala198	ala198	PROPN
dti-3271	114	16	.	.	PUNCT
dti-3271	115	1	it	it	PRON
dti-3271	115	2	is	be	AUX
dti-3271	115	3	inferred	infer	VERB
dti-3271	115	4	that	that	SCONJ
dti-3271	115	5	the	the	DET
dti-3271	115	6	formation	formation	NOUN
dti-3271	115	7	of	of	ADP
dti-3271	115	8	strong	strong	ADJ
dti-3271	115	9	interactions	interaction	NOUN
dti-3271	115	10	with	with	ADP
dti-3271	115	11	important	important	ADJ
dti-3271	115	12	residues	residue	NOUN
dti-3271	115	13	can	can	AUX
dti-3271	115	14	pinpoint	pinpoint	VERB
dti-3271	115	15	α	α	PRON
dti-3271	115	16	-	-	NOUN
dti-3271	115	17	amylase	amylase	NOUN
dti-3271	115	18	in	in	ADP
dti-3271	115	19	the	the	DET
dti-3271	115	20	binding	bind	VERB
dti-3271	115	21	pocket	pocket	NOUN
dti-3271	115	22	.	.	PUNCT
dti-3271	116	1	lastly	lastly	ADV
dti-3271	116	2	,	,	PUNCT
dti-3271	116	3	according	accord	VERB
dti-3271	116	4	to	to	ADP
dti-3271	116	5	the	the	DET
dti-3271	116	6	3d	3d	ADJ
dti-3271	116	7	-	-	PUNCT
dti-3271	116	8	molecular	molecular	ADJ
dti-3271	116	9	docking	docking	NOUN
dti-3271	116	10	,	,	PUNCT
dti-3271	116	11	the	the	DET
dti-3271	116	12	c2	c2	PROPN
dti-3271	116	13	prefers	prefer	VERB
dti-3271	116	14	a	a	DET
dti-3271	116	15	parallel	parallel	ADJ
dti-3271	116	16	orientation	orientation	NOUN
dti-3271	116	17	between	between	ADP
dti-3271	116	18	the	the	DET
dti-3271	116	19	central	central	ADJ
dti-3271	116	20	indoline	indoline	NOUN
dti-3271	116	21	ring	ring	NOUN
dti-3271	116	22	and	and	CCONJ
dti-3271	116	23	the	the	DET
dti-3271	116	24	important	important	ADJ
dti-3271	116	25	hydrophilic	hydrophilic	ADJ
dti-3271	116	26	asp	asp	NOUN
dti-3271	116	27	197	197	NUM
dti-3271	116	28	into	into	ADP
dti-3271	116	29	the	the	DET
dti-3271	116	30	binding	bind	VERB
dti-3271	116	31	pockets	pocket	NOUN
dti-3271	116	32	.	.	PUNCT
dti-3271	117	1	molecular	molecular	ADJ
dti-3271	117	2	dynamic	dynamic	ADJ
dti-3271	117	3	investigations	investigation	NOUN
dti-3271	117	4	of	of	ADP
dti-3271	117	5	c1	c1	PROPN
dti-3271	117	6	-	-	PUNCT
dti-3271	117	7	c2	c2	PROPN
dti-3271	117	8	in	in	ADP
dti-3271	117	9	order	order	NOUN
dti-3271	117	10	to	to	PART
dti-3271	117	11	comprehend	comprehend	VERB
dti-3271	117	12	enzymatic	enzymatic	ADJ
dti-3271	117	13	activity	activity	NOUN
dti-3271	117	14	and	and	CCONJ
dti-3271	117	15	create	create	VERB
dti-3271	117	16	inhibitors	inhibitor	NOUN
dti-3271	117	17	,	,	PUNCT
dti-3271	117	18	it	it	PRON
dti-3271	117	19	is	be	AUX
dti-3271	117	20	essential	essential	ADJ
dti-3271	117	21	to	to	PART
dti-3271	117	22	investigate	investigate	VERB
dti-3271	117	23	ligand	ligand	NOUN
dti-3271	117	24	-	-	PUNCT
dti-3271	117	25	enzyme	enzyme	NOUN
dti-3271	117	26	interactions	interaction	NOUN
dti-3271	117	27	,	,	PUNCT
dti-3271	117	28	like	like	ADP
dti-3271	117	29	the	the	DET
dti-3271	117	30	one	one	NOUN
dti-3271	117	31	that	that	PRON
dti-3271	117	32	exists	exist	VERB
dti-3271	117	33	between	between	ADP
dti-3271	117	34	the	the	DET
dti-3271	117	35	α	α	NOUN
dti-3271	117	36	-	-	PUNCT
dti-3271	117	37	glucosidase	glucosidase	ADJ
dti-3271	117	38	protein	protein	NOUN
dti-3271	117	39	and	and	CCONJ
dti-3271	117	40	a	a	DET
dti-3271	117	41	ligand	ligand	NOUN
dti-3271	117	42	.	.	PUNCT
dti-3271	118	1	molecular	molecular	ADJ
dti-3271	118	2	mechanics	mechanic	NOUN
dti-3271	118	3	-	-	PUNCT
dti-3271	118	4	poisson	poisson	NOUN
dti-3271	118	5	-	-	PUNCT
dti-3271	118	6	boltzmann	boltzmann	PROPN
dti-3271	118	7	surface	surface	NOUN
dti-3271	118	8	area	area	NOUN
dti-3271	118	9	(	(	PUNCT
dti-3271	118	10	mm	mm	NOUN
dti-3271	118	11	-	-	PUNCT
dti-3271	118	12	pbsa	pbsa	NOUN
dti-3271	118	13	)	)	PUNCT
dti-3271	118	14	computations	computation	NOUN
dti-3271	118	15	offer	offer	VERB
dti-3271	118	16	a	a	DET
dti-3271	118	17	thorough	thorough	ADJ
dti-3271	118	18	understanding	understanding	NOUN
dti-3271	118	19	of	of	ADP
dti-3271	118	20	the	the	DET
dti-3271	118	21	molecular	molecular	ADJ
dti-3271	118	22	binding	bind	VERB
dti-3271	118	23	processes	process	NOUN
dti-3271	118	24	.	.	PUNCT
dti-3271	119	1	the	the	DET
dti-3271	119	2	dynamic	dynamic	ADJ
dti-3271	119	3	nature	nature	NOUN
dti-3271	119	4	of	of	ADP
dti-3271	119	5	molecular	molecular	ADJ
dti-3271	119	6	interactions	interaction	NOUN
dti-3271	119	7	is	be	AUX
dti-3271	119	8	captured	capture	VERB
dti-3271	119	9	through	through	ADP
dti-3271	119	10	a	a	DET
dti-3271	119	11	rigorous	rigorous	ADJ
dti-3271	119	12	approach	approach	NOUN
dti-3271	119	13	of	of	ADP
dti-3271	119	14	accounting	account	VERB
dti-3271	119	15	for	for	ADP
dti-3271	119	16	the	the	DET
dti-3271	119	17	flexibility	flexibility	NOUN
dti-3271	119	18	of	of	ADP
dti-3271	119	19	α	α	NOUN
dti-3271	119	20	-	-	PUNCT
dti-3271	119	21	glucosidase	glucosidase	ADJ
dti-3271	119	22	figure	figure	NOUN
dti-3271	119	23	4	4	NUM
dti-3271	119	24	showing	show	VERB
dti-3271	119	25	3d	3d	NUM
dti-3271	119	26	docking	docking	NOUN
dti-3271	119	27	poses	pose	NOUN
dti-3271	119	28	of	of	ADP
dti-3271	119	29	c1	c1	NOUN
dti-3271	119	30	,	,	PUNCT
dti-3271	119	31	and	and	CCONJ
dti-3271	119	32	c2	c2	PROPN
dti-3271	119	33	against	against	ADP
dti-3271	119	34	αglucosidase	αglucosidase	PROPN
dti-3271	119	35	.	.	PUNCT
dti-3271	120	1	figure	figure	NOUN
dti-3271	120	2	5	5	NUM
dti-3271	120	3	showing	show	VERB
dti-3271	120	4	3d	3d	NUM
dti-3271	120	5	docking	docking	NOUN
dti-3271	120	6	poses	pose	NOUN
dti-3271	120	7	of	of	ADP
dti-3271	120	8	c1	c1	NOUN
dti-3271	120	9	,	,	PUNCT
dti-3271	120	10	and	and	CCONJ
dti-3271	120	11	c2	c2	PROPN
dti-3271	120	12	against	against	ADP
dti-3271	120	13	αamylase	αamylase	PROPN
dti-3271	120	14	.	.	PUNCT
dti-3271	121	1	rauf	rauf	PROPN
dti-3271	121	2	et	et	PROPN
dti-3271	121	3	al	al	PROPN
dti-3271	121	4	drug	drug	PROPN
dti-3271	121	5	target	target	NOUN
dti-3271	121	6	insights	insight	NOUN
dti-3271	121	7	2025	2025	NUM
dti-3271	121	8	;	;	PUNCT
dti-3271	121	9	19	19	NUM
dti-3271	121	10	:	:	SYM
dti-3271	121	11	15	15	NUM
dti-3271	121	12	©	©	ADP
dti-3271	121	13	2025	2025	NUM
dti-3271	121	14	the	the	DET
dti-3271	121	15	authors	author	NOUN
dti-3271	121	16	.	.	PUNCT
dti-3271	122	1	published	publish	VERB
dti-3271	122	2	by	by	ADP
dti-3271	122	3	aboutscience	aboutscience	NOUN
dti-3271	122	4	www.aboutscience.eu	www.aboutscience.eu	NOUN
dti-3271	122	5	protein	protein	NOUN
dti-3271	122	6	complexes	complex	NOUN
dti-3271	122	7	during	during	ADP
dti-3271	122	8	contact	contact	NOUN
dti-3271	122	9	tests	test	NOUN
dti-3271	122	10	at	at	ADP
dti-3271	122	11	2	2	NUM
dti-3271	122	12	ns	ns	NUM
dti-3271	122	13	intervals	interval	NOUN
dti-3271	122	14	.	.	PUNCT
dti-3271	123	1	the	the	DET
dti-3271	123	2	energy	energy	NOUN
dti-3271	123	3	changes	change	NOUN
dti-3271	123	4	in	in	ADP
dti-3271	123	5	figure	figure	NOUN
dti-3271	123	6	6	6	NUM
dti-3271	123	7	,	,	PUNCT
dti-3271	123	8	which	which	PRON
dti-3271	123	9	illustrate	illustrate	VERB
dti-3271	123	10	fluctuations	fluctuation	NOUN
dti-3271	123	11	in	in	ADP
dti-3271	123	12	the	the	DET
dti-3271	123	13	binding	bind	VERB
dti-3271	123	14	free	free	ADJ
dti-3271	123	15	energy	energy	NOUN
dti-3271	123	16	at	at	ADP
dti-3271	123	17	12	12	NUM
dti-3271	123	18	-	-	PUNCT
dti-3271	123	19	ns	ns	NUM
dti-3271	123	20	intervals	interval	NOUN
dti-3271	123	21	,	,	PUNCT
dti-3271	123	22	provide	provide	VERB
dti-3271	123	23	important	important	ADJ
dti-3271	123	24	information	information	NOUN
dti-3271	123	25	about	about	ADP
dti-3271	123	26	the	the	DET
dti-3271	123	27	strength	strength	NOUN
dti-3271	123	28	and	and	CCONJ
dti-3271	123	29	stability	stability	NOUN
dti-3271	123	30	of	of	ADP
dti-3271	123	31	the	the	DET
dti-3271	123	32	binding	binding	NOUN
dti-3271	123	33	throughout	throughout	ADP
dti-3271	123	34	time	time	NOUN
dti-3271	123	35	.	.	PUNCT
dti-3271	124	1	the	the	DET
dti-3271	124	2	significance	significance	NOUN
dti-3271	124	3	of	of	ADP
dti-3271	124	4	structural	structural	ADJ
dti-3271	124	5	variations	variation	NOUN
dti-3271	124	6	on	on	ADP
dti-3271	124	7	binding	bind	VERB
dti-3271	124	8	affinity	affinity	NOUN
dti-3271	124	9	is	be	AUX
dti-3271	124	10	highlighted	highlight	VERB
dti-3271	124	11	by	by	ADP
dti-3271	124	12	comparing	compare	VERB
dti-3271	124	13	the	the	DET
dti-3271	124	14	energy	energy	NOUN
dti-3271	124	15	changes	change	NOUN
dti-3271	124	16	of	of	ADP
dti-3271	124	17	the	the	DET
dti-3271	124	18	two	two	NUM
dti-3271	124	19	dichloroindolinone	dichloroindolinone	NOUN
dti-3271	124	20	molecules	molecule	NOUN
dti-3271	124	21	.	.	PUNCT
dti-3271	125	1	positive	positive	ADJ
dti-3271	125	2	interactions	interaction	NOUN
dti-3271	125	3	were	be	AUX
dti-3271	125	4	indicated	indicate	VERB
dti-3271	125	5	by	by	ADP
dti-3271	125	6	the	the	DET
dti-3271	125	7	binding	bind	VERB
dti-3271	125	8	parameter	parameter	NOUN
dti-3271	125	9	values	value	NOUN
dti-3271	125	10	that	that	PRON
dti-3271	125	11	are	be	AUX
dti-3271	125	12	negative	negative	ADJ
dti-3271	125	13	,	,	PUNCT
dti-3271	125	14	which	which	PRON
dti-3271	125	15	is	be	AUX
dti-3271	125	16	encouraging	encouraging	ADJ
dti-3271	125	17	for	for	ADP
dti-3271	125	18	the	the	DET
dti-3271	125	19	possible	possible	ADJ
dti-3271	125	20	effectiveness	effectiveness	NOUN
dti-3271	125	21	of	of	ADP
dti-3271	125	22	these	these	DET
dti-3271	125	23	compounds	compound	NOUN
dti-3271	125	24	as	as	ADP
dti-3271	125	25	inhibitors	inhibitor	NOUN
dti-3271	125	26	.	.	PUNCT
dti-3271	126	1	effective	effective	ADJ
dti-3271	126	2	binding	binding	NOUN
dti-3271	126	3	is	be	AUX
dti-3271	126	4	frequently	frequently	ADV
dti-3271	126	5	indicated	indicate	VERB
dti-3271	126	6	by	by	ADP
dti-3271	126	7	a	a	DET
dti-3271	126	8	strong	strong	ADJ
dti-3271	126	9	and	and	CCONJ
dti-3271	126	10	stable	stable	ADJ
dti-3271	126	11	hydrogen	hydrogen	NOUN
dti-3271	126	12	-	-	PUNCT
dti-3271	126	13	bonding	bonding	NOUN
dti-3271	126	14	pattern	pattern	NOUN
dti-3271	126	15	,	,	PUNCT
dti-3271	126	16	which	which	PRON
dti-3271	126	17	is	be	AUX
dti-3271	126	18	suggested	suggest	VERB
dti-3271	126	19	by	by	ADP
dti-3271	126	20	the	the	DET
dti-3271	126	21	minimal	minimal	ADJ
dti-3271	126	22	fluctuation	fluctuation	NOUN
dti-3271	126	23	in	in	ADP
dti-3271	126	24	mm	mm	NOUN
dti-3271	126	25	-	-	PUNCT
dti-3271	126	26	pbsa	pbsa	NOUN
dti-3271	126	27	values	value	NOUN
dti-3271	126	28	.	.	PUNCT
dti-3271	127	1	it	it	PRON
dti-3271	127	2	is	be	AUX
dti-3271	127	3	unsuitable	unsuitable	ADJ
dti-3271	127	4	for	for	ADP
dti-3271	127	5	illustrating	illustrate	VERB
dti-3271	127	6	the	the	DET
dti-3271	127	7	relationship	relationship	NOUN
dti-3271	127	8	between	between	ADP
dti-3271	127	9	molecular	molecular	ADJ
dti-3271	127	10	docking	docking	NOUN
dti-3271	127	11	computations	computation	NOUN
dti-3271	127	12	and	and	CCONJ
dti-3271	127	13	ligand	ligand	ADJ
dti-3271	127	14	-	-	PUNCT
dti-3271	127	15	protein	protein	NOUN
dti-3271	127	16	interactions	interaction	NOUN
dti-3271	127	17	at	at	ADP
dti-3271	127	18	the	the	DET
dti-3271	127	19	ns	ns	ADJ
dti-3271	127	20	level	level	NOUN
dti-3271	127	21	since	since	SCONJ
dti-3271	127	22	the	the	DET
dti-3271	127	23	ligand	ligand	ADJ
dti-3271	127	24	molecules	molecule	NOUN
dti-3271	127	25	are	be	AUX
dti-3271	127	26	rather	rather	ADV
dti-3271	127	27	flexible	flexible	ADJ
dti-3271	127	28	in	in	ADP
dti-3271	127	29	the	the	DET
dti-3271	127	30	calculations	calculation	NOUN
dti-3271	127	31	.	.	PUNCT
dti-3271	128	1	the	the	DET
dti-3271	128	2	ligand	ligand	NOUN
dti-3271	128	3	-	-	PUNCT
dti-3271	128	4	amylase	amylase	NOUN
dti-3271	128	5	protein	protein	NOUN
dti-3271	128	6	interaction	interaction	NOUN
dti-3271	128	7	is	be	AUX
dti-3271	128	8	performed	perform	VERB
dti-3271	128	9	at	at	ADP
dti-3271	128	10	250	250	NUM
dti-3271	128	11	ns	ns	NUM
dti-3271	128	12	using	use	VERB
dti-3271	128	13	mm	mm	NOUN
dti-3271	128	14	-	-	PUNCT
dti-3271	128	15	psba	psba	NOUN
dti-3271	128	16	calculations	calculation	NOUN
dti-3271	128	17	.	.	PUNCT
dti-3271	129	1	in	in	ADP
dti-3271	129	2	mm	mm	NOUN
dti-3271	129	3	-	-	PUNCT
dti-3271	129	4	psba	psba	NOUN
dti-3271	129	5	calculations	calculation	NOUN
dti-3271	129	6	,	,	PUNCT
dti-3271	129	7	all	all	DET
dti-3271	129	8	compounds	compound	NOUN
dti-3271	129	9	of	of	ADP
dti-3271	129	10	amylase	amylase	NOUN
dti-3271	129	11	protein	protein	NOUN
dti-3271	129	12	complexes	complex	NOUN
dti-3271	129	13	have	have	VERB
dti-3271	129	14	flexibility	flexibility	NOUN
dti-3271	129	15	when	when	SCONJ
dti-3271	129	16	checking	check	VERB
dti-3271	129	17	the	the	DET
dti-3271	129	18	interaction	interaction	NOUN
dti-3271	129	19	every	every	DET
dti-3271	129	20	2	2	NUM
dti-3271	129	21	ns	ns	NUM
dti-3271	129	22	,	,	PUNCT
dti-3271	129	23	and	and	CCONJ
dti-3271	129	24	the	the	DET
dti-3271	129	25	energy	energy	NOUN
dti-3271	129	26	change	change	NOUN
dti-3271	129	27	is	be	AUX
dti-3271	129	28	reported	report	VERB
dti-3271	129	29	in	in	ADP
dti-3271	129	30	figure	figure	NOUN
dti-3271	129	31	7	7	NUM
dti-3271	129	32	.	.	PUNCT
dti-3271	130	1	the	the	DET
dti-3271	130	2	resulting	result	VERB
dti-3271	130	3	graph	graph	NOUN
dti-3271	130	4	in	in	ADP
dti-3271	130	5	figure	figure	NOUN
dti-3271	130	6	7	7	NUM
dti-3271	130	7	depicts	depict	VERB
dti-3271	130	8	the	the	DET
dti-3271	130	9	binding	bind	VERB
dti-3271	130	10	free	free	ADJ
dti-3271	130	11	energy	energy	NOUN
dti-3271	130	12	changes	change	NOUN
dti-3271	130	13	and	and	CCONJ
dti-3271	130	14	variations	variation	NOUN
dti-3271	130	15	in	in	ADP
dti-3271	130	16	all	all	PRON
dti-3271	130	17	ten	ten	NUM
dti-3271	130	18	(	(	PUNCT
dti-3271	130	19	ns	ns	NOUN
dti-3271	130	20	)	)	PUNCT
dti-3271	130	21	intervals	interval	NOUN
dti-3271	130	22	.	.	PUNCT
dti-3271	131	1	the	the	DET
dti-3271	131	2	energy	energy	NOUN
dti-3271	131	3	changes	change	NOUN
dti-3271	131	4	of	of	ADP
dti-3271	131	5	the	the	DET
dti-3271	131	6	most	most	ADV
dti-3271	131	7	active	active	ADJ
dti-3271	131	8	two	two	NUM
dti-3271	131	9	2	2	NUM
dti-3271	131	10	,	,	PUNCT
dti-3271	131	11	3	3	NUM
dti-3271	131	12	and	and	CCONJ
dti-3271	131	13	2	2	NUM
dti-3271	131	14	,	,	PUNCT
dti-3271	131	15	6	6	NUM
dti-3271	131	16	-	-	PUNCT
dti-3271	131	17	dichloroindolinone	dichloroindolinone	NOUN
dti-3271	131	18	molecules	molecule	NOUN
dti-3271	131	19	were	be	AUX
dti-3271	131	20	compared	compare	VERB
dti-3271	131	21	,	,	PUNCT
dti-3271	131	22	and	and	CCONJ
dti-3271	131	23	the	the	DET
dti-3271	131	24	calculations	calculation	NOUN
dti-3271	131	25	were	be	AUX
dti-3271	131	26	performed	perform	VERB
dti-3271	131	27	to	to	PART
dti-3271	131	28	validate	validate	VERB
dti-3271	131	29	the	the	DET
dti-3271	131	30	determination	determination	NOUN
dti-3271	131	31	of	of	ADP
dti-3271	131	32	bonding	bond	VERB
dti-3271	131	33	free	free	ADJ
dti-3271	131	34	energies	energy	NOUN
dti-3271	131	35	using	use	VERB
dti-3271	131	36	the	the	DET
dti-3271	131	37	molecular	molecular	ADJ
dti-3271	131	38	mmpbsa	mmpbsa	NOUN
dti-3271	131	39	approach	approach	NOUN
dti-3271	131	40	.	.	PUNCT
dti-3271	132	1	negative	negative	ADJ
dti-3271	132	2	values	value	NOUN
dti-3271	132	3	for	for	ADP
dti-3271	132	4	the	the	DET
dti-3271	132	5	relevant	relevant	ADJ
dti-3271	132	6	parameters	parameter	NOUN
dti-3271	132	7	indicate	indicate	VERB
dti-3271	132	8	improved	improved	ADJ
dti-3271	132	9	binding	bind	VERB
dti-3271	132	10	.	.	PUNCT
dti-3271	133	1	the	the	DET
dti-3271	133	2	small	small	ADJ
dti-3271	133	3	fluctuations	fluctuation	NOUN
dti-3271	133	4	for	for	ADP
dti-3271	133	5	mm	mm	NOUN
dti-3271	133	6	-	-	PUNCT
dti-3271	133	7	pbsa	pbsa	NOUN
dti-3271	133	8	for	for	ADP
dti-3271	133	9	both	both	PRON
dti-3271	133	10	complexed	complexe	VERB
dti-3271	133	11	with	with	ADP
dti-3271	133	12	amylase	amylase	NOUN
dti-3271	133	13	over	over	ADP
dti-3271	133	14	the	the	DET
dti-3271	133	15	entire	entire	ADJ
dti-3271	133	16	time	time	NOUN
dti-3271	133	17	scale	scale	NOUN
dti-3271	133	18	indicated	indicate	VERB
dti-3271	133	19	a	a	DET
dti-3271	133	20	robust	robust	ADJ
dti-3271	133	21	contact	contact	NOUN
dti-3271	133	22	between	between	ADP
dti-3271	133	23	ligand	ligand	NOUN
dti-3271	133	24	and	and	CCONJ
dti-3271	133	25	amino	amino	NOUN
dti-3271	133	26	acid	acid	NOUN
dti-3271	133	27	backbone	backbone	NOUN
dti-3271	133	28	,	,	PUNCT
dti-3271	133	29	indicating	indicate	VERB
dti-3271	133	30	a	a	DET
dti-3271	133	31	firm	firm	ADJ
dti-3271	133	32	h	h	NOUN
dti-3271	133	33	-	-	PUNCT
dti-3271	133	34	bonding	bonding	NOUN
dti-3271	133	35	pattern	pattern	NOUN
dti-3271	133	36	.	.	PUNCT
dti-3271	134	1	discussion	discussion	NOUN
dti-3271	134	2	the	the	DET
dti-3271	134	3	study	study	NOUN
dti-3271	134	4	revealed	reveal	VERB
dti-3271	134	5	significant	significant	ADJ
dti-3271	134	6	in	in	ADP
dti-3271	134	7	vitro	vitro	X
dti-3271	134	8	α	α	NOUN
dti-3271	134	9	-	-	NOUN
dti-3271	134	10	glucosidase	glucosidase	ADJ
dti-3271	134	11	and	and	CCONJ
dti-3271	134	12	α	α	NOUN
dti-3271	134	13	-	-	PUNCT
dti-3271	134	14	amylase	amylase	NOUN
dti-3271	134	15	inhibition	inhibition	NOUN
dti-3271	134	16	of	of	ADP
dti-3271	134	17	oxindoles	oxindole	NOUN
dti-3271	134	18	,	,	PUNCT
dti-3271	134	19	2	2	NUM
dti-3271	134	20	,	,	PUNCT
dti-3271	134	21	3	3	NUM
dti-3271	134	22	dichloroindolinone	dichloroindolinone	NOUN
dti-3271	134	23	(	(	PUNCT
dti-3271	134	24	c1	c1	PROPN
dti-3271	134	25	)	)	PUNCT
dti-3271	134	26	and	and	CCONJ
dti-3271	134	27	2	2	NUM
dti-3271	134	28	,	,	PUNCT
dti-3271	134	29	6	6	NUM
dti-3271	134	30	-	-	PUNCT
dti-3271	134	31	dichloroindolinone	dichloroindolinone	NOUN
dti-3271	134	32	(	(	PUNCT
dti-3271	134	33	c2	c2	PROPN
dti-3271	134	34	)	)	PUNCT
dti-3271	134	35	,	,	PUNCT
dti-3271	134	36	which	which	PRON
dti-3271	134	37	were	be	AUX
dti-3271	134	38	molecular	molecular	ADJ
dti-3271	134	39	docking	docking	NOUN
dti-3271	134	40	and	and	CCONJ
dti-3271	134	41	simulation	simulation	NOUN
dti-3271	134	42	studies	study	NOUN
dti-3271	134	43	.	.	PUNCT
dti-3271	135	1	the	the	DET
dti-3271	135	2	development	development	NOUN
dti-3271	135	3	of	of	ADP
dti-3271	135	4	a	a	DET
dti-3271	135	5	new	new	ADJ
dti-3271	135	6	,	,	PUNCT
dti-3271	135	7	more	more	ADV
dti-3271	135	8	effective	effective	ADJ
dti-3271	135	9	molecule	molecule	NOUN
dti-3271	135	10	with	with	ADP
dti-3271	135	11	lower	low	ADJ
dti-3271	135	12	toxicity	toxicity	NOUN
dti-3271	135	13	is	be	AUX
dti-3271	135	14	always	always	ADV
dti-3271	135	15	a	a	DET
dti-3271	135	16	primary	primary	ADJ
dti-3271	135	17	target	target	NOUN
dti-3271	135	18	in	in	ADP
dti-3271	135	19	research	research	NOUN
dti-3271	135	20	(	(	PUNCT
dti-3271	135	21	21	21	NUM
dti-3271	135	22	)	)	PUNCT
dti-3271	135	23	.	.	PUNCT
dti-3271	136	1	dichloroindolinone	dichloroindolinone	NOUN
dti-3271	136	2	are	be	AUX
dti-3271	136	3	oxindole	oxindole	NOUN
dti-3271	136	4	derivatives	derivative	NOUN
dti-3271	136	5	that	that	PRON
dti-3271	136	6	are	be	AUX
dti-3271	136	7	utilized	utilize	VERB
dti-3271	136	8	for	for	ADP
dti-3271	136	9	a	a	DET
dti-3271	136	10	wide	wide	ADJ
dti-3271	136	11	range	range	NOUN
dti-3271	136	12	of	of	ADP
dti-3271	136	13	biological	biological	ADJ
dti-3271	136	14	effects	effect	NOUN
dti-3271	136	15	(	(	PUNCT
dti-3271	136	16	10,22,23	10,22,23	NUM
dti-3271	136	17	)	)	PUNCT
dti-3271	136	18	.	.	PUNCT
dti-3271	137	1	enzymes	enzyme	NOUN
dti-3271	137	2	belonging	belong	VERB
dti-3271	137	3	to	to	ADP
dti-3271	137	4	the	the	DET
dti-3271	137	5	glucosidases	glucosidase	NOUN
dti-3271	137	6	are	be	AUX
dti-3271	137	7	present	present	ADJ
dti-3271	137	8	on	on	ADP
dti-3271	137	9	the	the	DET
dti-3271	137	10	brush	brush	NOUN
dti-3271	137	11	boundary	boundary	ADJ
dti-3271	137	12	surface	surface	NOUN
dti-3271	137	13	of	of	ADP
dti-3271	137	14	intestinal	intestinal	ADJ
dti-3271	137	15	microglia	microglia	NOUN
dti-3271	137	16	.	.	PUNCT
dti-3271	138	1	they	they	PRON
dti-3271	138	2	cause	cause	VERB
dti-3271	138	3	starch	starch	NOUN
dti-3271	138	4	1,4	1,4	NUM
dti-3271	138	5	-	-	ADJ
dti-3271	138	6	glycosidic	glycosidic	ADJ
dti-3271	138	7	bonds	bond	NOUN
dti-3271	138	8	to	to	PART
dti-3271	138	9	break	break	VERB
dti-3271	138	10	,	,	PUNCT
dti-3271	138	11	releasing	release	VERB
dti-3271	138	12	–	–	PUNCT
dti-3271	138	13	d	d	NOUN
dti-3271	138	14	-	-	NOUN
dti-3271	138	15	glucose	glucose	NOUN
dti-3271	138	16	,	,	PUNCT
dti-3271	138	17	which	which	PRON
dti-3271	138	18	is	be	AUX
dti-3271	138	19	absorbed	absorb	VERB
dti-3271	138	20	.	.	PUNCT
dti-3271	139	1	it	it	PRON
dti-3271	139	2	consequently	consequently	ADV
dti-3271	139	3	raises	raise	VERB
dti-3271	139	4	post	post	ADJ
dti-3271	139	5	-	-	ADJ
dti-3271	139	6	meal	meal	ADJ
dti-3271	139	7	hyperglycemia	hyperglycemia	NOUN
dti-3271	139	8	.	.	PUNCT
dti-3271	140	1	therefore	therefore	ADV
dti-3271	140	2	,	,	PUNCT
dti-3271	140	3	it	it	PRON
dti-3271	140	4	is	be	AUX
dti-3271	140	5	essential	essential	ADJ
dti-3271	140	6	to	to	PART
dti-3271	140	7	use	use	VERB
dti-3271	140	8	these	these	DET
dti-3271	140	9	enzyme	enzyme	NOUN
dti-3271	140	10	inhibitors	inhibitor	NOUN
dti-3271	140	11	in	in	ADP
dti-3271	140	12	the	the	DET
dti-3271	140	13	management	management	NOUN
dti-3271	140	14	of	of	ADP
dti-3271	140	15	type	type	NOUN
dti-3271	140	16	ii	ii	NOUN
dti-3271	140	17	diabetes	diabetes	NOUN
dti-3271	140	18	.	.	PUNCT
dti-3271	141	1	a	a	DET
dti-3271	141	2	class	class	NOUN
dti-3271	141	3	of	of	ADP
dti-3271	141	4	enzymes	enzyme	NOUN
dti-3271	141	5	known	know	VERB
dti-3271	141	6	as	as	ADP
dti-3271	141	7	α	α	NOUN
dti-3271	141	8	-	-	PUNCT
dti-3271	141	9	glucosidases	glucosidase	NOUN
dti-3271	141	10	hydrolyzes	hydrolyze	VERB
dti-3271	141	11	the	the	DET
dti-3271	141	12	1	1	NUM
dti-3271	141	13	,	,	PUNCT
dti-3271	141	14	4	4	NUM
dti-3271	141	15	-	-	PUNCT
dti-3271	141	16	glycosidic	glycosidic	ADJ
dti-3271	141	17	bond	bond	NOUN
dti-3271	141	18	in	in	ADP
dti-3271	141	19	starch	starch	NOUN
dti-3271	141	20	to	to	PART
dti-3271	141	21	produce	produce	VERB
dti-3271	141	22	α	α	PRON
dti-3271	141	23	-	-	PUNCT
dti-3271	141	24	d	d	NOUN
dti-3271	141	25	-	-	PUNCT
dti-3271	141	26	glucose	glucose	NOUN
dti-3271	141	27	,	,	PUNCT
dti-3271	141	28	which	which	PRON
dti-3271	141	29	enters	enter	VERB
dti-3271	141	30	the	the	DET
dti-3271	141	31	bloodstream	bloodstream	NOUN
dti-3271	141	32	after	after	ADP
dti-3271	141	33	absorption	absorption	NOUN
dti-3271	141	34	(	(	PUNCT
dti-3271	141	35	24	24	NUM
dti-3271	141	36	)	)	PUNCT
dti-3271	141	37	.	.	PUNCT
dti-3271	142	1	as	as	ADP
dti-3271	142	2	a	a	DET
dti-3271	142	3	result	result	NOUN
dti-3271	142	4	,	,	PUNCT
dti-3271	142	5	it	it	PRON
dti-3271	142	6	causes	cause	VERB
dti-3271	142	7	post	post	ADJ
dti-3271	142	8	-	-	ADJ
dti-3271	142	9	meal	meal	ADJ
dti-3271	142	10	hyperglycemia	hyperglycemia	NOUN
dti-3271	142	11	.	.	PUNCT
dti-3271	143	1	as	as	ADP
dti-3271	143	2	a	a	DET
dti-3271	143	3	result	result	NOUN
dti-3271	143	4	,	,	PUNCT
dti-3271	143	5	using	use	VERB
dti-3271	143	6	these	these	DET
dti-3271	143	7	enzyme	enzyme	NOUN
dti-3271	143	8	inhibitors	inhibitor	NOUN
dti-3271	143	9	is	be	AUX
dti-3271	143	10	essential	essential	ADJ
dti-3271	143	11	for	for	ADP
dti-3271	143	12	managing	manage	VERB
dti-3271	143	13	t2	t2	NOUN
dti-3271	143	14	dm	dm	NOUN
dti-3271	143	15	.	.	PUNCT
dti-3271	143	16	proper	proper	ADJ
dti-3271	143	17	absorption	absorption	NOUN
dti-3271	143	18	and	and	CCONJ
dti-3271	143	19	digestion	digestion	NOUN
dti-3271	143	20	of	of	ADP
dti-3271	143	21	monosaccharides	monosaccharide	NOUN
dti-3271	143	22	may	may	AUX
dti-3271	143	23	help	help	VERB
dti-3271	143	24	avoid	avoid	VERB
dti-3271	143	25	diabetes	diabetes	NOUN
dti-3271	143	26	,	,	PUNCT
dti-3271	143	27	obesity	obesity	NOUN
dti-3271	143	28	,	,	PUNCT
dti-3271	143	29	hyperlipoproteinemia	hyperlipoproteinemia	NOUN
dti-3271	143	30	,	,	PUNCT
dti-3271	143	31	and	and	CCONJ
dti-3271	143	32	hyperlipidemia	hyperlipidemia	NOUN
dti-3271	143	33	(	(	PUNCT
dti-3271	143	34	25	25	NUM
dti-3271	143	35	)	)	PUNCT
dti-3271	143	36	.	.	PUNCT
dti-3271	144	1	these	these	DET
dti-3271	144	2	inhibitors	inhibitor	NOUN
dti-3271	144	3	may	may	AUX
dti-3271	144	4	be	be	AUX
dti-3271	144	5	used	use	VERB
dti-3271	144	6	to	to	PART
dti-3271	144	7	treat	treat	VERB
dti-3271	144	8	malignancies	malignancy	NOUN
dti-3271	144	9	,	,	PUNCT
dti-3271	144	10	viral	viral	ADJ
dti-3271	144	11	infections	infection	NOUN
dti-3271	144	12	,	,	PUNCT
dti-3271	144	13	and	and	CCONJ
dti-3271	144	14	several	several	ADJ
dti-3271	144	15	other	other	ADJ
dti-3271	144	16	diseases	disease	NOUN
dti-3271	144	17	,	,	PUNCT
dti-3271	144	18	as	as	ADV
dti-3271	144	19	well	well	ADV
dti-3271	144	20	as	as	ADP
dti-3271	144	21	to	to	PART
dti-3271	144	22	regulate	regulate	VERB
dti-3271	144	23	the	the	DET
dti-3271	144	24	immune	immune	ADJ
dti-3271	144	25	system	system	NOUN
dti-3271	144	26	(	(	PUNCT
dti-3271	144	27	13	13	NUM
dti-3271	144	28	)	)	PUNCT
dti-3271	144	29	.	.	PUNCT
dti-3271	145	1	the	the	DET
dti-3271	145	2	early	early	ADJ
dti-3271	145	3	metabolism	metabolism	NOUN
dti-3271	145	4	abnormality	abnormality	NOUN
dti-3271	145	5	that	that	PRON
dti-3271	145	6	arises	arise	VERB
dti-3271	145	7	in	in	ADP
dti-3271	145	8	niddm	niddm	NOUN
dti-3271	145	9	,	,	PUNCT
dti-3271	145	10	postprandial	postprandial	ADJ
dti-3271	145	11	hyperglycemia	hyperglycemia	NOUN
dti-3271	145	12	,	,	PUNCT
dti-3271	145	13	has	have	AUX
dti-3271	145	14	been	be	AUX
dti-3271	145	15	identified	identify	VERB
dti-3271	145	16	as	as	ADP
dti-3271	145	17	a	a	DET
dti-3271	145	18	potential	potential	ADJ
dti-3271	145	19	therapy	therapy	NOUN
dti-3271	145	20	for	for	ADP
dti-3271	145	21	glucosidase	glucosidase	PROPN
dti-3271	145	22	(	(	PUNCT
dti-3271	145	23	26	26	NUM
dti-3271	145	24	)	)	PUNCT
dti-3271	145	25	.	.	PUNCT
dti-3271	146	1	our	our	PRON
dti-3271	146	2	finding	finding	NOUN
dti-3271	146	3	on	on	ADP
dti-3271	146	4	the	the	DET
dti-3271	146	5	test	test	NOUN
dti-3271	146	6	compounds	compound	NOUN
dti-3271	146	7	showed	show	VERB
dti-3271	146	8	significant	significant	ADJ
dti-3271	146	9	inhibition	inhibition	NOUN
dti-3271	146	10	of	of	ADP
dti-3271	146	11	the	the	DET
dti-3271	146	12	enzyme	enzyme	NOUN
dti-3271	146	13	by	by	ADP
dti-3271	146	14	both	both	DET
dti-3271	146	15	compounds	compound	NOUN
dti-3271	146	16	and	and	CCONJ
dti-3271	146	17	,	,	PUNCT
dti-3271	146	18	therefore	therefore	ADV
dti-3271	146	19	,	,	PUNCT
dti-3271	146	20	could	could	AUX
dti-3271	146	21	be	be	AUX
dti-3271	146	22	potential	potential	ADJ
dti-3271	146	23	candidates	candidate	NOUN
dti-3271	146	24	as	as	ADP
dti-3271	146	25	glucosidase	glucosidase	ADJ
dti-3271	146	26	inhibitors	inhibitor	NOUN
dti-3271	146	27	.	.	PUNCT
dti-3271	147	1	the	the	DET
dti-3271	147	2	hydrolase	hydrolase	NOUN
dti-3271	147	3	enzyme	enzyme	NOUN
dti-3271	147	4	α	α	NOUN
dti-3271	147	5	-	-	PUNCT
dti-3271	147	6	amylase	amylase	NOUN
dti-3271	147	7	catalyzes	catalyze	VERB
dti-3271	147	8	the	the	DET
dti-3271	147	9	hydrolysis	hydrolysis	NOUN
dti-3271	147	10	of	of	ADP
dti-3271	147	11	internal	internal	ADJ
dti-3271	147	12	-1	-1	ADJ
dti-3271	147	13	,	,	PUNCT
dti-3271	147	14	4	4	NUM
dti-3271	147	15	-	-	PUNCT
dti-3271	147	16	glycosidic	glycosidic	ADJ
dti-3271	147	17	bonds	bond	NOUN
dti-3271	147	18	in	in	ADP
dti-3271	147	19	starch	starch	NOUN
dti-3271	147	20	to	to	PART
dti-3271	147	21	create	create	VERB
dti-3271	147	22	products	product	NOUN
dti-3271	147	23	like	like	ADP
dti-3271	147	24	glucose	glucose	NOUN
dti-3271	147	25	and	and	CCONJ
dti-3271	147	26	maltose	maltose	NOUN
dti-3271	147	27	.	.	PUNCT
dti-3271	148	1	since	since	SCONJ
dti-3271	148	2	it	it	PRON
dti-3271	148	3	is	be	AUX
dti-3271	148	4	a	a	DET
dti-3271	148	5	calcium	calcium	NOUN
dti-3271	148	6	metalloenzyme	metalloenzyme	NOUN
dti-3271	148	7	,	,	PUNCT
dti-3271	148	8	a	a	DET
dti-3271	148	9	metal	metal	NOUN
dti-3271	148	10	cofactor	cofactor	NOUN
dti-3271	148	11	is	be	AUX
dti-3271	148	12	necessary	necessary	ADJ
dti-3271	148	13	for	for	SCONJ
dti-3271	148	14	it	it	PRON
dti-3271	148	15	to	to	PART
dti-3271	148	16	function	function	VERB
dti-3271	148	17	(	(	PUNCT
dti-3271	148	18	27	27	NUM
dti-3271	148	19	)	)	PUNCT
dti-3271	148	20	.	.	PUNCT
dti-3271	149	1	the	the	DET
dti-3271	149	2	class	class	NOUN
dti-3271	149	3	of	of	ADP
dti-3271	149	4	enzymes	enzyme	NOUN
dti-3271	149	5	known	know	VERB
dti-3271	149	6	as	as	ADP
dti-3271	149	7	amylases	amylase	NOUN
dti-3271	149	8	is	be	AUX
dti-3271	149	9	responsible	responsible	ADJ
dti-3271	149	10	for	for	ADP
dti-3271	149	11	hydrolyzing	hydrolyze	VERB
dti-3271	149	12	starch	starch	NOUN
dti-3271	149	13	to	to	PART
dti-3271	149	14	produce	produce	VERB
dti-3271	149	15	low	low	ADJ
dti-3271	149	16	-	-	PUNCT
dti-3271	149	17	molecular	molecular	ADJ
dti-3271	149	18	-	-	PUNCT
dti-3271	149	19	weight	weight	NOUN
dti-3271	149	20	dextrins	dextrin	NOUN
dti-3271	149	21	and	and	CCONJ
dti-3271	149	22	sugars	sugar	NOUN
dti-3271	149	23	,	,	PUNCT
dti-3271	149	24	and	and	CCONJ
dti-3271	149	25	they	they	PRON
dti-3271	149	26	are	be	AUX
dti-3271	149	27	crucial	crucial	ADJ
dti-3271	149	28	for	for	ADP
dti-3271	149	29	the	the	DET
dti-3271	149	30	digestion	digestion	NOUN
dti-3271	149	31	of	of	ADP
dti-3271	149	32	carbohydrates	carbohydrate	NOUN
dti-3271	149	33	.	.	PUNCT
dti-3271	150	1	maltose	maltose	VERB
dti-3271	150	2	,	,	PUNCT
dti-3271	150	3	maltotriose	maltotriose	PROPN
dti-3271	150	4	,	,	PUNCT
dti-3271	150	5	and	and	CCONJ
dti-3271	150	6	other	other	ADJ
dti-3271	150	7	(	(	PUNCT
dti-3271	150	8	1,6	1,6	NUM
dti-3271	150	9	)	)	PUNCT
dti-3271	150	10	and	and	CCONJ
dti-3271	150	11	(	(	PUNCT
dti-3271	150	12	1,4	1,4	NUM
dti-3271	150	13	)	)	PUNCT
dti-3271	150	14	oligoglucans	oligoglucan	NOUN
dti-3271	150	15	can	can	AUX
dti-3271	150	16	be	be	AUX
dti-3271	150	17	broken	break	VERB
dti-3271	150	18	down	down	ADP
dti-3271	150	19	into	into	ADP
dti-3271	150	20	glucose	glucose	NOUN
dti-3271	150	21	by	by	ADP
dti-3271	150	22	various	various	ADJ
dti-3271	150	23	α	α	NOUN
dti-3271	150	24	-	-	NOUN
dti-3271	150	25	glucosidases	glucosidase	NOUN
dti-3271	150	26	and	and	CCONJ
dti-3271	150	27	are	be	AUX
dti-3271	150	28	the	the	DET
dti-3271	150	29	primary	primary	ADJ
dti-3271	150	30	components	component	NOUN
dti-3271	150	31	of	of	ADP
dti-3271	150	32	the	the	DET
dti-3271	150	33	final	final	ADJ
dti-3271	150	34	hydrolysate	hydrolysate	NOUN
dti-3271	150	35	.	.	PUNCT
dti-3271	151	1	controlling	control	VERB
dti-3271	151	2	the	the	DET
dti-3271	151	3	activity	activity	NOUN
dti-3271	151	4	of	of	ADP
dti-3271	151	5	hpa	hpa	NOUN
dti-3271	151	6	,	,	PUNCT
dti-3271	151	7	which	which	PRON
dti-3271	151	8	is	be	AUX
dti-3271	151	9	a	a	DET
dti-3271	151	10	human	human	ADJ
dti-3271	151	11	pancreatic	pancreatic	ADJ
dti-3271	151	12	enzyme	enzyme	NOUN
dti-3271	151	13	that	that	PRON
dti-3271	151	14	is	be	AUX
dti-3271	151	15	essential	essential	ADJ
dti-3271	151	16	for	for	ADP
dti-3271	151	17	the	the	DET
dti-3271	151	18	digestion	digestion	NOUN
dti-3271	151	19	of	of	ADP
dti-3271	151	20	starch	starch	NOUN
dti-3271	151	21	,	,	PUNCT
dti-3271	151	22	could	could	AUX
dti-3271	151	23	effectively	effectively	ADV
dti-3271	151	24	lower	lower	VERB
dti-3271	151	25	blood	blood	NOUN
dti-3271	151	26	glucose	glucose	NOUN
dti-3271	151	27	levels	level	NOUN
dti-3271	151	28	after	after	ADP
dti-3271	151	29	meals	meal	NOUN
dti-3271	151	30	(	(	PUNCT
dti-3271	151	31	28	28	NUM
dti-3271	151	32	)	)	PUNCT
dti-3271	151	33	.	.	PUNCT
dti-3271	152	1	when	when	SCONJ
dti-3271	152	2	combined	combine	VERB
dti-3271	152	3	,	,	PUNCT
dti-3271	152	4	α	α	NOUN
dti-3271	152	5	-	-	NOUN
dti-3271	152	6	glucosidase	glucosidase	ADJ
dti-3271	152	7	and	and	CCONJ
dti-3271	152	8	α	α	NOUN
dti-3271	152	9	-	-	PUNCT
dti-3271	152	10	amylase	amylase	NOUN
dti-3271	152	11	inhibition	inhibition	NOUN
dti-3271	152	12	can	can	AUX
dti-3271	152	13	significantly	significantly	ADV
dti-3271	152	14	reduce	reduce	VERB
dti-3271	152	15	the	the	DET
dti-3271	152	16	rise	rise	NOUN
dti-3271	152	17	in	in	ADP
dti-3271	152	18	blood	blood	NOUN
dti-3271	152	19	glucose	glucose	NOUN
dti-3271	152	20	that	that	PRON
dti-3271	152	21	occurs	occur	VERB
dti-3271	152	22	after	after	ADP
dti-3271	152	23	meals	meal	NOUN
dti-3271	152	24	and	and	CCONJ
dti-3271	152	25	could	could	AUX
dti-3271	152	26	be	be	AUX
dti-3271	152	27	an	an	DET
dti-3271	152	28	essential	essential	ADJ
dti-3271	152	29	strategy	strategy	NOUN
dti-3271	152	30	for	for	ADP
dti-3271	152	31	controlling	control	VERB
dti-3271	152	32	blood	blood	NOUN
dti-3271	152	33	glucose	glucose	NOUN
dti-3271	152	34	levels	level	NOUN
dti-3271	152	35	in	in	ADP
dti-3271	152	36	people	people	NOUN
dti-3271	152	37	with	with	ADP
dti-3271	152	38	t2	t2	NOUN
dti-3271	152	39	dm	dm	PROPN
dti-3271	152	40	.	.	PUNCT
dti-3271	153	1	the	the	DET
dti-3271	153	2	main	main	ADJ
dti-3271	153	3	treatment	treatment	NOUN
dti-3271	153	4	targets	target	NOUN
dti-3271	153	5	for	for	ADP
dti-3271	153	6	type-2	type-2	NUM
dti-3271	153	7	dm	dm	PROPN
dti-3271	153	8	are	be	AUX
dti-3271	153	9	thus	thus	ADV
dti-3271	153	10	pancreatic	pancreatic	ADJ
dti-3271	153	11	α	α	NOUN
dti-3271	153	12	-	-	NOUN
dti-3271	153	13	amylase	amylase	NOUN
dti-3271	153	14	and	and	CCONJ
dti-3271	153	15	gut	gut	NOUN
dti-3271	153	16	glucoamylases	glucoamylase	NOUN
dti-3271	153	17	.	.	PUNCT
dti-3271	154	1	amylase	amylase	NOUN
dti-3271	154	2	antagonists	antagonist	NOUN
dti-3271	154	3	are	be	AUX
dti-3271	154	4	already	already	ADV
dti-3271	154	5	available	available	ADJ
dti-3271	154	6	on	on	ADP
dti-3271	154	7	figure	figure	NOUN
dti-3271	154	8	6	6	NUM
dti-3271	154	9	the	the	DET
dti-3271	154	10	values	value	NOUN
dti-3271	154	11	of	of	ADP
dti-3271	154	12	the	the	DET
dti-3271	154	13	test	test	NOUN
dti-3271	154	14	compounds	compound	VERB
dti-3271	154	15	c1	c1	PROPN
dti-3271	154	16	and	and	CCONJ
dti-3271	154	17	c2	c2	PROPN
dti-3271	154	18	for	for	ADP
dti-3271	154	19	the	the	DET
dti-3271	154	20	gibbs	gibbs	PROPN
dti-3271	154	21	free	free	ADJ
dti-3271	154	22	energy	energy	NOUN
dti-3271	154	23	of	of	ADP
dti-3271	154	24	ligand	ligand	ADJ
dti-3271	154	25	α	α	PROPN
dti-3271	154	26	-	-	PUNCT
dti-3271	154	27	glucosidase	glucosidase	ADJ
dti-3271	154	28	protein	protein	NOUN
dti-3271	154	29	.	.	PUNCT
dti-3271	155	1	figure	figure	VERB
dti-3271	155	2	7	7	NUM
dti-3271	155	3	the	the	DET
dti-3271	155	4	values	value	NOUN
dti-3271	155	5	of	of	ADP
dti-3271	155	6	the	the	DET
dti-3271	155	7	test	test	NOUN
dti-3271	155	8	compounds	compound	VERB
dti-3271	155	9	c1	c1	PROPN
dti-3271	155	10	and	and	CCONJ
dti-3271	155	11	c2	c2	PROPN
dti-3271	155	12	for	for	ADP
dti-3271	155	13	the	the	DET
dti-3271	155	14	gibbs	gibbs	PROPN
dti-3271	155	15	free	free	ADJ
dti-3271	155	16	energy	energy	NOUN
dti-3271	155	17	of	of	ADP
dti-3271	155	18	ligand	ligand	ADJ
dti-3271	155	19	α	α	NOUN
dti-3271	155	20	-	-	PUNCT
dti-3271	155	21	amylase	amylase	NOUN
dti-3271	155	22	protein	protein	NOUN
dti-3271	155	23	.	.	PUNCT
dti-3271	156	1	anti	anti	ADJ
dti-3271	156	2	-	-	ADJ
dti-3271	156	3	diabetic	diabetic	ADJ
dti-3271	156	4	effects	effect	NOUN
dti-3271	156	5	of	of	ADP
dti-3271	156	6	dichloroindolinone16	dichloroindolinone16	NOUN
dti-3271	156	7	©	©	PROPN
dti-3271	156	8	2025	2025	NUM
dti-3271	156	9	the	the	DET
dti-3271	156	10	authors	author	NOUN
dti-3271	156	11	.	.	PUNCT
dti-3271	157	1	drug	drug	NOUN
dti-3271	157	2	target	target	NOUN
dti-3271	157	3	insights	insight	NOUN
dti-3271	157	4	issn	issn	VERB
dti-3271	157	5	1177	1177	NUM
dti-3271	157	6	-	-	SYM
dti-3271	157	7	3928	3928	NUM
dti-3271	157	8	www.aboutscience.eu/dti	www.aboutscience.eu/dti	VERB
dti-3271	157	9	the	the	DET
dti-3271	157	10	market	market	NOUN
dti-3271	157	11	for	for	ADP
dti-3271	157	12	the	the	DET
dti-3271	157	13	treatment	treatment	NOUN
dti-3271	157	14	of	of	ADP
dti-3271	157	15	diabetes	diabetes	NOUN
dti-3271	157	16	.	.	PUNCT
dti-3271	158	1	amylase	amylase	NOUN
dti-3271	158	2	inhibitors	inhibitor	NOUN
dti-3271	158	3	can	can	AUX
dti-3271	158	4	also	also	ADV
dti-3271	158	5	be	be	AUX
dti-3271	158	6	used	use	VERB
dti-3271	158	7	to	to	PART
dti-3271	158	8	treat	treat	VERB
dti-3271	158	9	obesity	obesity	NOUN
dti-3271	158	10	(	(	PUNCT
dti-3271	158	11	29	29	NUM
dti-3271	158	12	)	)	PUNCT
dti-3271	158	13	.	.	PUNCT
dti-3271	159	1	we	we	PRON
dti-3271	159	2	observed	observe	VERB
dti-3271	159	3	strong	strong	ADJ
dti-3271	159	4	inhibition	inhibition	NOUN
dti-3271	159	5	of	of	ADP
dti-3271	159	6	the	the	DET
dti-3271	159	7	α	α	NOUN
dti-3271	159	8	-	-	NOUN
dti-3271	159	9	amylase	amylase	NOUN
dti-3271	159	10	by	by	ADP
dti-3271	159	11	the	the	DET
dti-3271	159	12	test	test	NOUN
dti-3271	159	13	compounds	compound	NOUN
dti-3271	159	14	at	at	ADP
dti-3271	159	15	various	various	ADJ
dti-3271	159	16	concentrations	concentration	NOUN
dti-3271	159	17	and	and	CCONJ
dti-3271	159	18	therefore	therefore	ADV
dti-3271	159	19	augmented	augment	VERB
dti-3271	159	20	the	the	DET
dti-3271	159	21	overall	overall	ADJ
dti-3271	159	22	antidiabetic	antidiabetic	ADJ
dti-3271	159	23	potential	potential	NOUN
dti-3271	159	24	of	of	ADP
dti-3271	159	25	these	these	DET
dti-3271	159	26	compounds	compound	NOUN
dti-3271	159	27	as	as	ADP
dti-3271	159	28	strong	strong	ADJ
dti-3271	159	29	candidates	candidate	NOUN
dti-3271	159	30	for	for	ADP
dti-3271	159	31	further	further	ADJ
dti-3271	159	32	studies	study	NOUN
dti-3271	159	33	.	.	PUNCT
dti-3271	160	1	molecular	molecular	ADJ
dti-3271	160	2	docking	docking	NOUN
dti-3271	160	3	tests	test	NOUN
dti-3271	160	4	revealed	reveal	VERB
dti-3271	160	5	that	that	SCONJ
dti-3271	160	6	the	the	DET
dti-3271	160	7	bestranked	bestranke	VERB
dti-3271	160	8	conformation	conformation	NOUN
dti-3271	160	9	of	of	ADP
dti-3271	160	10	the	the	DET
dti-3271	160	11	test	test	NOUN
dti-3271	160	12	compounds	compound	NOUN
dti-3271	160	13	fit	fit	ADJ
dti-3271	160	14	into	into	ADP
dti-3271	160	15	the	the	DET
dti-3271	160	16	site	site	NOUN
dti-3271	160	17	of	of	ADP
dti-3271	160	18	activity	activity	NOUN
dti-3271	160	19	well	well	ADV
dti-3271	160	20	,	,	PUNCT
dti-3271	160	21	and	and	CCONJ
dti-3271	160	22	its	its	PRON
dti-3271	160	23	oxindole	oxindole	NOUN
dti-3271	160	24	moiety	moiety	NOUN
dti-3271	160	25	interacted	interact	VERB
dti-3271	160	26	with	with	ADP
dti-3271	160	27	important	important	ADJ
dti-3271	160	28	locations	location	NOUN
dti-3271	160	29	in	in	ADP
dti-3271	160	30	the	the	DET
dti-3271	160	31	binding	bind	VERB
dti-3271	160	32	pocket	pocket	NOUN
dti-3271	160	33	.	.	PUNCT
dti-3271	161	1	the	the	DET
dti-3271	161	2	interaction	interaction	NOUN
dti-3271	161	3	between	between	ADP
dti-3271	161	4	ligands	ligand	NOUN
dti-3271	161	5	and	and	CCONJ
dti-3271	161	6	enzymes	enzyme	NOUN
dti-3271	161	7	was	be	AUX
dti-3271	161	8	studied	study	VERB
dti-3271	161	9	in	in	ADP
dti-3271	161	10	docking	dock	VERB
dti-3271	161	11	investigations	investigation	NOUN
dti-3271	161	12	to	to	PART
dti-3271	161	13	gain	gain	VERB
dti-3271	161	14	a	a	DET
dti-3271	161	15	greater	great	ADJ
dti-3271	161	16	understanding	understanding	NOUN
dti-3271	161	17	of	of	ADP
dti-3271	161	18	the	the	DET
dti-3271	161	19	in	in	ADV
dti-3271	161	20	vitro	vitro	X
dti-3271	161	21	outcomes	outcome	NOUN
dti-3271	161	22	.	.	PUNCT
dti-3271	162	1	the	the	DET
dti-3271	162	2	structure	structure	NOUN
dti-3271	162	3	data	datum	NOUN
dti-3271	162	4	for	for	ADP
dti-3271	162	5	the	the	DET
dti-3271	162	6	selected	select	VERB
dti-3271	162	7	enzymes	enzyme	NOUN
dti-3271	162	8	was	be	AUX
dti-3271	162	9	obtained	obtain	VERB
dti-3271	162	10	by	by	ADP
dti-3271	162	11	searching	search	VERB
dti-3271	162	12	the	the	DET
dti-3271	162	13	protein	protein	NOUN
dti-3271	162	14	data	datum	NOUN
dti-3271	162	15	bank	bank	NOUN
dti-3271	162	16	.	.	PUNCT
dti-3271	163	1	the	the	DET
dti-3271	163	2	pdb	pdb	PROPN
dti-3271	163	3	ids	id	VERB
dti-3271	163	4	for	for	ADP
dti-3271	163	5	αamylase	αamylase	PROPN
dti-3271	163	6	and	and	CCONJ
dti-3271	163	7	α	α	NOUN
dti-3271	163	8	-	-	NOUN
dti-3271	163	9	glucosidase	glucosidase	PROPN
dti-3271	163	10	were	be	AUX
dti-3271	163	11	4gqr	4gqr	NUM
dti-3271	163	12	and	and	CCONJ
dti-3271	163	13	5nn5	5nn5	NUM
dti-3271	163	14	,	,	PUNCT
dti-3271	163	15	respectively	respectively	ADV
dti-3271	163	16	(	(	PUNCT
dti-3271	163	17	28	28	NUM
dti-3271	163	18	,	,	PUNCT
dti-3271	163	19	30	30	NUM
dti-3271	163	20	)	)	PUNCT
dti-3271	163	21	.	.	PUNCT
dti-3271	164	1	the	the	DET
dti-3271	164	2	process	process	NOUN
dti-3271	164	3	and	and	CCONJ
dti-3271	164	4	enzyme	enzyme	NOUN
dti-3271	164	5	preparation	preparation	NOUN
dti-3271	164	6	were	be	AUX
dti-3271	164	7	completed	complete	VERB
dti-3271	164	8	with	with	ADP
dti-3271	164	9	the	the	DET
dti-3271	164	10	aid	aid	NOUN
dti-3271	164	11	of	of	ADP
dti-3271	164	12	the	the	DET
dti-3271	164	13	molecular	molecular	ADJ
dti-3271	164	14	operating	operating	NOUN
dti-3271	164	15	environment	environment	NOUN
dti-3271	164	16	(	(	PUNCT
dti-3271	164	17	moe	moe	NOUN
dti-3271	164	18	)	)	PUNCT
dti-3271	164	19	software	software	NOUN
dti-3271	164	20	.	.	PUNCT
dti-3271	165	1	the	the	DET
dti-3271	165	2	enzymes	enzyme	NOUN
dti-3271	165	3	were	be	AUX
dti-3271	165	4	first	first	ADV
dti-3271	165	5	removed	remove	VERB
dti-3271	165	6	from	from	ADP
dti-3271	165	7	non	non	ADJ
dti-3271	165	8	-	-	ADJ
dti-3271	165	9	standard	standard	ADJ
dti-3271	165	10	structures	structure	NOUN
dti-3271	165	11	and	and	CCONJ
dti-3271	165	12	inadequate	inadequate	ADJ
dti-3271	165	13	bounded	bound	VERB
dti-3271	165	14	ligands	ligand	NOUN
dti-3271	165	15	in	in	ADP
dti-3271	165	16	order	order	NOUN
dti-3271	165	17	to	to	PART
dti-3271	165	18	prepare	prepare	VERB
dti-3271	165	19	them	they	PRON
dti-3271	165	20	for	for	ADP
dti-3271	165	21	docking	docking	NOUN
dti-3271	165	22	in	in	ADP
dti-3271	165	23	pdb	pdb	PROPN
dti-3271	165	24	format	format	NOUN
dti-3271	165	25	.	.	PUNCT
dti-3271	166	1	binding	bind	VERB
dti-3271	166	2	energies	energy	NOUN
dti-3271	166	3	were	be	AUX
dti-3271	166	4	investigated	investigate	VERB
dti-3271	166	5	,	,	PUNCT
dti-3271	166	6	and	and	CCONJ
dti-3271	166	7	docking	docking	NOUN
dti-3271	166	8	method	method	NOUN
dti-3271	166	9	outcomes	outcome	NOUN
dti-3271	166	10	were	be	AUX
dti-3271	166	11	evaluated	evaluate	VERB
dti-3271	166	12	.	.	PUNCT
dti-3271	167	1	it	it	PRON
dti-3271	167	2	was	be	AUX
dti-3271	167	3	demonstrated	demonstrate	VERB
dti-3271	167	4	that	that	SCONJ
dti-3271	167	5	the	the	DET
dti-3271	167	6	optimal	optimal	ADJ
dti-3271	167	7	ligand	ligand	ADJ
dti-3271	167	8	-	-	PUNCT
dti-3271	167	9	enzyme	enzyme	NOUN
dti-3271	167	10	interaction	interaction	NOUN
dti-3271	167	11	model	model	NOUN
dti-3271	167	12	produced	produce	VERB
dti-3271	167	13	increased	increase	VERB
dti-3271	167	14	negative	negative	ADJ
dti-3271	167	15	values	value	NOUN
dti-3271	167	16	;	;	PUNCT
dti-3271	167	17	the	the	DET
dti-3271	167	18	more	more	ADV
dti-3271	167	19	negative	negative	ADJ
dti-3271	167	20	values	value	NOUN
dti-3271	167	21	,	,	PUNCT
dti-3271	167	22	the	the	PRON
dti-3271	167	23	greater	great	ADJ
dti-3271	167	24	the	the	DET
dti-3271	167	25	probability	probability	NOUN
dti-3271	167	26	of	of	ADP
dti-3271	167	27	binding	bind	VERB
dti-3271	167	28	at	at	ADP
dti-3271	167	29	that	that	DET
dti-3271	167	30	particular	particular	ADJ
dti-3271	167	31	site	site	NOUN
dti-3271	167	32	.	.	PUNCT
dti-3271	168	1	various	various	ADJ
dti-3271	168	2	situations	situation	NOUN
dti-3271	168	3	were	be	AUX
dti-3271	168	4	used	use	VERB
dti-3271	168	5	in	in	ADP
dti-3271	168	6	order	order	NOUN
dti-3271	168	7	to	to	PART
dti-3271	168	8	see	see	VERB
dti-3271	168	9	the	the	DET
dti-3271	168	10	key	key	ADJ
dti-3271	168	11	interaction	interaction	NOUN
dti-3271	168	12	between	between	ADP
dti-3271	168	13	the	the	DET
dti-3271	168	14	ligands	ligand	NOUN
dti-3271	168	15	and	and	CCONJ
dti-3271	168	16	enzymes	enzyme	NOUN
dti-3271	168	17	,	,	PUNCT
dti-3271	168	18	amino	amino	NOUN
dti-3271	168	19	acid	acid	NOUN
dti-3271	168	20	residues	residue	NOUN
dti-3271	168	21	,	,	PUNCT
dti-3271	168	22	binding	bind	VERB
dti-3271	168	23	pocket	pocket	NOUN
dti-3271	168	24	,	,	PUNCT
dti-3271	168	25	and	and	CCONJ
dti-3271	168	26	bond	bond	NOUN
dti-3271	168	27	lengths	length	NOUN
dti-3271	168	28	were	be	AUX
dti-3271	168	29	presented	present	VERB
dti-3271	168	30	in	in	ADP
dti-3271	168	31	different	different	ADJ
dti-3271	168	32	colors	color	NOUN
dti-3271	168	33	.	.	PUNCT
dti-3271	169	1	the	the	DET
dti-3271	169	2	lowest	low	ADJ
dti-3271	169	3	score	score	NOUN
dti-3271	169	4	poses	pose	NOUN
dti-3271	169	5	,	,	PUNCT
dti-3271	169	6	and	and	CCONJ
dti-3271	169	7	rmsd	rmsd	PROPN
dti-3271	169	8	revealed	reveal	VERB
dti-3271	169	9	increased	increase	VERB
dti-3271	169	10	stability	stability	NOUN
dti-3271	169	11	in	in	ADP
dti-3271	169	12	the	the	DET
dti-3271	169	13	binding	bind	VERB
dti-3271	169	14	pocket	pocket	NOUN
dti-3271	169	15	.	.	PUNCT
dti-3271	170	1	the	the	DET
dti-3271	170	2	data	datum	NOUN
dti-3271	170	3	was	be	AUX
dti-3271	170	4	utilized	utilize	VERB
dti-3271	170	5	to	to	PART
dti-3271	170	6	rank	rank	VERB
dti-3271	170	7	the	the	DET
dti-3271	170	8	docked	dock	VERB
dti-3271	170	9	poses	pose	NOUN
dti-3271	170	10	and	and	CCONJ
dti-3271	170	11	to	to	PART
dti-3271	170	12	select	select	VERB
dti-3271	170	13	the	the	DET
dti-3271	170	14	most	most	ADV
dti-3271	170	15	capable	capable	ADJ
dti-3271	170	16	docked	docked	ADJ
dti-3271	170	17	conformation	conformation	NOUN
dti-3271	170	18	of	of	ADP
dti-3271	170	19	each	each	DET
dti-3271	170	20	compound	compound	NOUN
dti-3271	170	21	.	.	PUNCT
dti-3271	171	1	the	the	DET
dti-3271	171	2	hetero	hetero	NOUN
dti-3271	171	3	ring	ring	NOUN
dti-3271	171	4	for	for	ADP
dti-3271	171	5	erlotinib	erlotinib	NOUN
dti-3271	171	6	and	and	CCONJ
dti-3271	171	7	benzimidazole	benzimidazole	NOUN
dti-3271	171	8	centered	center	VERB
dti-3271	171	9	on	on	ADP
dti-3271	171	10	the	the	DET
dti-3271	171	11	α	α	NOUN
dti-3271	171	12	-	-	PUNCT
dti-3271	171	13	amylase	amylase	NOUN
dti-3271	171	14	pocket	pocket	NOUN
dti-3271	171	15	and	and	CCONJ
dti-3271	171	16	interacted	interact	VERB
dti-3271	171	17	with	with	ADP
dti-3271	171	18	his	his	PRON
dti-3271	171	19	305	305	NUM
dti-3271	171	20	,	,	PUNCT
dti-3271	171	21	asp	asp	PROPN
dti-3271	171	22	300	300	NUM
dti-3271	171	23	,	,	PUNCT
dti-3271	171	24	ala198	ala198	PROPN
dti-3271	171	25	,	,	PUNCT
dti-3271	171	26	asp	asp	NOUN
dti-3271	171	27	197	197	NUM
dti-3271	171	28	,	,	PUNCT
dti-3271	171	29	thr	thr	PROPN
dti-3271	171	30	163	163	NUM
dti-3271	171	31	,	,	PUNCT
dti-3271	171	32	leu162	leu162	PROPN
dti-3271	171	33	,	,	PUNCT
dti-3271	171	34	tyr	tyr	PROPN
dti-3271	171	35	151	151	NUM
dti-3271	171	36	,	,	PUNCT
dti-3271	171	37	gln	gln	NOUN
dti-3271	171	38	63	63	NUM
dti-3271	171	39	,	,	PUNCT
dti-3271	171	40	trp	trp	PROPN
dti-3271	171	41	59	59	NUM
dti-3271	171	42	.	.	PUNCT
dti-3271	172	1	in	in	ADP
dti-3271	172	2	the	the	DET
dti-3271	172	3	mm	mm	NOUN
dti-3271	172	4	-	-	PUNCT
dti-3271	172	5	pbsa	pbsa	NOUN
dti-3271	172	6	calculations	calculation	NOUN
dti-3271	172	7	,	,	PUNCT
dti-3271	172	8	the	the	DET
dti-3271	172	9	ligand	ligand	NOUN
dti-3271	172	10	-	-	PUNCT
dti-3271	172	11	glucosidase	glucosidase	NOUN
dti-3271	172	12	and	and	CCONJ
dti-3271	172	13	amylase	amylase	NOUN
dti-3271	172	14	protein	protein	NOUN
dti-3271	172	15	interaction	interaction	NOUN
dti-3271	172	16	is	be	AUX
dti-3271	172	17	monitored	monitor	VERB
dti-3271	172	18	every	every	DET
dti-3271	172	19	2	2	NUM
dti-3271	172	20	ns	ns	NOUN
dti-3271	172	21	.	.	PUNCT
dti-3271	173	1	the	the	DET
dti-3271	173	2	negative	negative	ADJ
dti-3271	173	3	values	value	NOUN
dti-3271	173	4	indicate	indicate	VERB
dti-3271	173	5	improved	improved	ADJ
dti-3271	173	6	binding	bind	VERB
dti-3271	173	7	(	(	PUNCT
dti-3271	173	8	more	more	ADV
dti-3271	173	9	favorable	favorable	ADJ
dti-3271	173	10	interactions	interaction	NOUN
dti-3271	173	11	)	)	PUNCT
dti-3271	173	12	.	.	PUNCT
dti-3271	174	1	the	the	DET
dti-3271	174	2	small	small	ADJ
dti-3271	174	3	fluctuations	fluctuation	NOUN
dti-3271	174	4	observed	observe	VERB
dti-3271	174	5	for	for	ADP
dti-3271	174	6	mm	mm	NOUN
dti-3271	174	7	-	-	PUNCT
dti-3271	174	8	pbsa	pbsa	NOUN
dti-3271	174	9	over	over	ADP
dti-3271	174	10	the	the	DET
dti-3271	174	11	entire	entire	ADJ
dti-3271	174	12	time	time	NOUN
dti-3271	174	13	scale	scale	NOUN
dti-3271	174	14	suggest	suggest	VERB
dti-3271	174	15	a	a	DET
dti-3271	174	16	stable	stable	ADJ
dti-3271	174	17	interaction	interaction	NOUN
dti-3271	174	18	.	.	PUNCT
dti-3271	175	1	the	the	DET
dti-3271	175	2	robust	robust	ADJ
dti-3271	175	3	contact	contact	NOUN
dti-3271	175	4	between	between	ADP
dti-3271	175	5	the	the	DET
dti-3271	175	6	ligand	ligand	NOUN
dti-3271	175	7	and	and	CCONJ
dti-3271	175	8	the	the	DET
dti-3271	175	9	amino	amino	NOUN
dti-3271	175	10	acid	acid	NOUN
dti-3271	175	11	backbone	backbone	NOUN
dti-3271	175	12	indicates	indicate	VERB
dti-3271	175	13	firm	firm	ADJ
dti-3271	175	14	hydrogen	hydrogen	NOUN
dti-3271	175	15	bonding	bonding	NOUN
dti-3271	175	16	.	.	PUNCT
dti-3271	176	1	conclusion	conclusion	NOUN
dti-3271	176	2	in	in	ADP
dti-3271	176	3	a	a	DET
dti-3271	176	4	dose	dose	NOUN
dti-3271	176	5	-	-	PUNCT
dti-3271	176	6	dependent	dependent	ADJ
dti-3271	176	7	way	way	NOUN
dti-3271	176	8	,	,	PUNCT
dti-3271	176	9	the	the	DET
dti-3271	176	10	6	6	NUM
dti-3271	176	11	-	-	PUNCT
dti-3271	176	12	chlorooxindole	chlorooxindole	NOUN
dti-3271	176	13	-	-	PUNCT
dti-3271	176	14	derived	derive	VERB
dti-3271	176	15	compounds	compound	NOUN
dti-3271	176	16	c1	c1	PROPN
dti-3271	176	17	and	and	CCONJ
dti-3271	176	18	c2	c2	PROPN
dti-3271	176	19	showed	show	VERB
dti-3271	176	20	potential	potential	NOUN
dti-3271	176	21	in	in	ADP
dti-3271	176	22	vitro	vitro	X
dti-3271	176	23	α	α	NOUN
dti-3271	176	24	-	-	NOUN
dti-3271	176	25	glucosidase	glucosidase	ADJ
dti-3271	176	26	and	and	CCONJ
dti-3271	176	27	α	α	NOUN
dti-3271	176	28	-	-	PUNCT
dti-3271	176	29	amylase	amylase	NOUN
dti-3271	176	30	inhibition	inhibition	NOUN
dti-3271	176	31	.	.	PUNCT
dti-3271	177	1	c1	c1	PROPN
dti-3271	177	2	and	and	CCONJ
dti-3271	177	3	c2	c2	PROPN
dti-3271	177	4	demonstrated	demonstrate	VERB
dti-3271	177	5	a	a	DET
dti-3271	177	6	high	high	ADJ
dti-3271	177	7	binding	binding	ADJ
dti-3271	177	8	and	and	CCONJ
dti-3271	177	9	inhibitory	inhibitory	ADJ
dti-3271	177	10	potential	potential	NOUN
dti-3271	177	11	when	when	SCONJ
dti-3271	177	12	docked	dock	VERB
dti-3271	177	13	with	with	ADP
dti-3271	177	14	the	the	DET
dti-3271	177	15	enzyme	enzyme	NOUN
dti-3271	177	16	α	α	NOUN
dti-3271	177	17	-	-	NOUN
dti-3271	177	18	glucosidase	glucosidase	ADJ
dti-3271	177	19	(	(	PUNCT
dti-3271	177	20	5nn5	5nn5	NUM
dti-3271	177	21	)	)	PUNCT
dti-3271	177	22	and	and	CCONJ
dti-3271	177	23	α	α	NOUN
dti-3271	177	24	-	-	NOUN
dti-3271	177	25	amylase	amylase	NOUN
dti-3271	177	26	(	(	PUNCT
dti-3271	177	27	4gqr	4gqr	NOUN
dti-3271	177	28	)	)	PUNCT
dti-3271	177	29	enzyme	enzyme	NOUN
dti-3271	177	30	.	.	PUNCT
dti-3271	178	1	strong	strong	ADJ
dti-3271	178	2	alignment	alignment	NOUN
dti-3271	178	3	with	with	ADP
dti-3271	178	4	the	the	DET
dti-3271	178	5	enzyme	enzyme	NOUN
dti-3271	178	6	backbone	backbone	NOUN
dti-3271	178	7	was	be	AUX
dti-3271	178	8	achieved	achieve	VERB
dti-3271	178	9	by	by	ADP
dti-3271	178	10	the	the	DET
dti-3271	178	11	active	active	ADJ
dti-3271	178	12	chemicals	chemical	NOUN
dti-3271	178	13	c1	c1	PROPN
dti-3271	178	14	and	and	CCONJ
dti-3271	178	15	c2	c2	PROPN
dti-3271	178	16	interacting	interact	VERB
dti-3271	178	17	primarily	primarily	ADV
dti-3271	178	18	with	with	ADP
dti-3271	178	19	the	the	DET
dti-3271	178	20	active	active	ADJ
dti-3271	178	21	site	site	NOUN
dti-3271	178	22	residues	residue	NOUN
dti-3271	178	23	through	through	ADP
dti-3271	178	24	polar	polar	ADJ
dti-3271	178	25	bonds	bond	NOUN
dti-3271	178	26	,	,	PUNCT
dti-3271	178	27	hydrogen	hydrogen	NOUN
dti-3271	178	28	bonding	bonding	NOUN
dti-3271	178	29	,	,	PUNCT
dti-3271	178	30	π−π	π−π	PROPN
dti-3271	178	31	,	,	PUNCT
dti-3271	178	32	and	and	CCONJ
dti-3271	178	33	π−h	π−h	NOUN
dti-3271	178	34	interactions	interaction	NOUN
dti-3271	178	35	.	.	PUNCT
dti-3271	179	1	the	the	DET
dti-3271	179	2	minimal	minimal	ADJ
dti-3271	179	3	fluctuation	fluctuation	NOUN
dti-3271	179	4	in	in	ADP
dti-3271	179	5	mm	mm	NOUN
dti-3271	179	6	-	-	PUNCT
dti-3271	179	7	pbsa	pbsa	NOUN
dti-3271	179	8	values	value	NOUN
dti-3271	179	9	suggests	suggest	VERB
dti-3271	179	10	a	a	DET
dti-3271	179	11	consistent	consistent	ADJ
dti-3271	179	12	and	and	CCONJ
dti-3271	179	13	strong	strong	ADJ
dti-3271	179	14	hydrogenbonding	hydrogenbonding	NOUN
dti-3271	179	15	pattern	pattern	NOUN
dti-3271	179	16	,	,	PUNCT
dti-3271	179	17	which	which	PRON
dti-3271	179	18	is	be	AUX
dti-3271	179	19	often	often	ADV
dti-3271	179	20	a	a	DET
dti-3271	179	21	hallmark	hallmark	NOUN
dti-3271	179	22	of	of	ADP
dti-3271	179	23	effective	effective	ADJ
dti-3271	179	24	binding	binding	NOUN
dti-3271	179	25	.	.	PUNCT
dti-3271	180	1	the	the	DET
dti-3271	180	2	present	present	ADJ
dti-3271	180	3	investigation	investigation	NOUN
dti-3271	180	4	reveals	reveal	VERB
dti-3271	180	5	improved	improve	VERB
dti-3271	180	6	anti	anti	ADJ
dti-3271	180	7	-	-	ADJ
dti-3271	180	8	diabetic	diabetic	ADJ
dti-3271	180	9	features	feature	NOUN
dti-3271	180	10	for	for	ADP
dti-3271	180	11	the	the	DET
dti-3271	180	12	6	6	NUM
dti-3271	180	13	-	-	PUNCT
dti-3271	180	14	chlorooxindole	chlorooxindole	NOUN
dti-3271	180	15	derivatives	derivative	NOUN
dti-3271	180	16	.	.	PUNCT
dti-3271	181	1	these	these	DET
dti-3271	181	2	focused	focus	VERB
dti-3271	181	3	compounds	compound	NOUN
dti-3271	181	4	could	could	AUX
dti-3271	181	5	help	help	VERB
dti-3271	181	6	develop	develop	VERB
dti-3271	181	7	more	more	ADV
dti-3271	181	8	potent	potent	ADJ
dti-3271	181	9	antihyperglycemic	antihyperglycemic	ADJ
dti-3271	181	10	medications	medication	NOUN
dti-3271	181	11	in	in	ADP
dti-3271	181	12	the	the	DET
dti-3271	181	13	future	future	NOUN
dti-3271	181	14	,	,	PUNCT
dti-3271	181	15	but	but	CCONJ
dti-3271	181	16	need	need	VERB
dti-3271	181	17	further	far	ADV
dti-3271	181	18	detailed	detailed	ADJ
dti-3271	181	19	studies	study	NOUN
dti-3271	181	20	.	.	PUNCT
dti-3271	182	1	acknowledgments	acknowledgment	NOUN
dti-3271	182	2	the	the	DET
dti-3271	182	3	authors	author	NOUN
dti-3271	182	4	extend	extend	VERB
dti-3271	182	5	their	their	PRON
dti-3271	182	6	appreciation	appreciation	NOUN
dti-3271	182	7	to	to	ADP
dti-3271	182	8	the	the	DET
dti-3271	182	9	researchers	researcher	NOUN
dti-3271	182	10	supporting	support	VERB
dti-3271	182	11	project	project	NOUN
dti-3271	182	12	number	number	NOUN
dti-3271	182	13	(	(	PUNCT
dti-3271	182	14	rspd2025r812	rspd2025r812	PROPN
dti-3271	182	15	)	)	PUNCT
dti-3271	182	16	,	,	PUNCT
dti-3271	182	17	king	king	PROPN
dti-3271	182	18	saud	saud	PROPN
dti-3271	182	19	university	university	PROPN
dti-3271	182	20	,	,	PUNCT
dti-3271	182	21	riyadh	riyadh	PROPN
dti-3271	182	22	,	,	PUNCT
dti-3271	182	23	saudi	saudi	PROPN
dti-3271	182	24	arabia	arabia	PROPN
dti-3271	182	25	,	,	PUNCT
dti-3271	182	26	for	for	ADP
dti-3271	182	27	funding	funding	NOUN
dti-3271	182	28	.	.	PUNCT
dti-3271	183	1	disclosures	disclosure	VERB
dti-3271	183	2	financial	financial	ADJ
dti-3271	183	3	support	support	NOUN
dti-3271	183	4	:	:	PUNCT
dti-3271	183	5	the	the	DET
dti-3271	183	6	authors	author	NOUN
dti-3271	183	7	extend	extend	VERB
dti-3271	183	8	their	their	PRON
dti-3271	183	9	appreciation	appreciation	NOUN
dti-3271	183	10	to	to	ADP
dti-3271	183	11	the	the	DET
dti-3271	183	12	researchers	researcher	NOUN
dti-3271	183	13	supporting	support	VERB
dti-3271	183	14	project	project	NOUN
dti-3271	183	15	number	number	NOUN
dti-3271	183	16	(	(	PUNCT
dti-3271	183	17	rspd2025r812	rspd2025r812	PROPN
dti-3271	183	18	)	)	PUNCT
dti-3271	183	19	,	,	PUNCT
dti-3271	183	20	king	king	PROPN
dti-3271	183	21	saud	saud	PROPN
dti-3271	183	22	university	university	PROPN
dti-3271	183	23	,	,	PUNCT
dti-3271	183	24	riyadh	riyadh	PROPN
dti-3271	183	25	,	,	PUNCT
dti-3271	183	26	saudi	saudi	PROPN
dti-3271	183	27	arabia	arabia	PROPN
dti-3271	183	28	,	,	PUNCT
dti-3271	183	29	for	for	ADP
dti-3271	183	30	funding	funding	NOUN
dti-3271	183	31	.	.	PUNCT
dti-3271	184	1	conflict	conflict	NOUN
dti-3271	184	2	of	of	ADP
dti-3271	184	3	interest	interest	NOUN
dti-3271	184	4	:	:	PUNCT
dti-3271	184	5	the	the	DET
dti-3271	184	6	authors	author	NOUN
dti-3271	184	7	of	of	ADP
dti-3271	184	8	this	this	DET
dti-3271	184	9	article	article	NOUN
dti-3271	184	10	declare	declare	VERB
dti-3271	184	11	no	no	DET
dti-3271	184	12	conflict	conflict	NOUN
dti-3271	184	13	of	of	ADP
dti-3271	184	14	interest	interest	NOUN
dti-3271	184	15	.	.	PUNCT
dti-3271	185	1	data	datum	NOUN
dti-3271	185	2	availability	availability	NOUN
dti-3271	185	3	statement	statement	NOUN
dti-3271	185	4	:	:	PUNCT
dti-3271	185	5	the	the	DET
dti-3271	185	6	data	datum	NOUN
dti-3271	185	7	that	that	PRON
dti-3271	185	8	support	support	VERB
dti-3271	185	9	the	the	DET
dti-3271	185	10	findings	finding	NOUN
dti-3271	185	11	of	of	ADP
dti-3271	185	12	the	the	DET
dti-3271	185	13	present	present	ADJ
dti-3271	185	14	study	study	NOUN
dti-3271	185	15	are	be	AUX
dti-3271	185	16	available	available	ADJ
dti-3271	185	17	from	from	ADP
dti-3271	185	18	the	the	DET
dti-3271	185	19	corresponding	correspond	VERB
dti-3271	185	20	authors	author	NOUN
dti-3271	185	21	upon	upon	SCONJ
dti-3271	185	22	reasonable	reasonable	ADJ
dti-3271	185	23	request	request	NOUN
dti-3271	185	24	.	.	PUNCT
dti-3271	186	1	references	reference	NOUN
dti-3271	186	2	1	1	NUM
dti-3271	186	3	.	.	PUNCT
dti-3271	186	4	sagbo	sagbo	PROPN
dti-3271	186	5	ij	ij	PROPN
dti-3271	186	6	,	,	PUNCT
dti-3271	186	7	van	van	PROPN
dti-3271	186	8	de	de	PROPN
dti-3271	186	9	venter	venter	PROPN
dti-3271	186	10	m	m	PROPN
dti-3271	186	11	,	,	PUNCT
dti-3271	186	12	koekemoer	koekemoer	PROPN
dti-3271	186	13	t	t	PROPN
dti-3271	186	14	,	,	PUNCT
dti-3271	186	15	et	et	PROPN
dti-3271	186	16	al	al	PROPN
dti-3271	186	17	.	.	PROPN
dti-3271	187	1	in	in	ADP
dti-3271	187	2	vitro	vitro	X
dti-3271	187	3	anti	anti	X
dti-3271	187	4	diabetic	diabetic	ADJ
dti-3271	187	5	activity	activity	NOUN
dti-3271	187	6	and	and	CCONJ
dti-3271	187	7	mechanism	mechanism	NOUN
dti-3271	187	8	of	of	ADP
dti-3271	187	9	action	action	NOUN
dti-3271	187	10	of	of	ADP
dti-3271	187	11	brachylaena	brachylaena	PROPN
dti-3271	187	12	elliptica	elliptica	PROPN
dti-3271	187	13	(	(	PUNCT
dti-3271	187	14	thunb	thunb	NOUN
dti-3271	187	15	.	.	PUNCT
dti-3271	187	16	)	)	PUNCT
dti-3271	188	1	dc	dc	PROPN
dti-3271	188	2	.	.	PUNCT
dti-3271	188	3	evidence	evidence	NOUN
dti-3271	188	4	-	-	PUNCT
dti-3271	188	5	based	base	VERB
dti-3271	188	6	complementary	complementary	ADJ
dti-3271	188	7	and	and	CCONJ
dti-3271	188	8	alternative	alternative	ADJ
dti-3271	188	9	medicine	medicine	NOUN
dti-3271	188	10	,	,	PUNCT
dti-3271	188	11	2018	2018	NUM
dti-3271	188	12	.	.	PUNCT
dti-3271	189	1	crossref	crossref	PROPN
dti-3271	189	2	pubmed	pubmed	PROPN
dti-3271	189	3	2	2	PROPN
dti-3271	189	4	.	.	PUNCT
dti-3271	190	1	galicia	galicia	PROPN
dti-3271	190	2	-	-	PUNCT
dti-3271	190	3	garcia	garcia	PROPN
dti-3271	190	4	u	u	PROPN
dti-3271	190	5	,	,	PUNCT
dti-3271	190	6	benito	benito	PROPN
dti-3271	190	7	-	-	PROPN
dti-3271	190	8	vicente	vicente	PROPN
dti-3271	190	9	a	a	PRON
dti-3271	190	10	,	,	PUNCT
dti-3271	190	11	jebari	jebari	PROPN
dti-3271	190	12	s	s	PART
dti-3271	190	13	,	,	PUNCT
dti-3271	190	14	et	et	PROPN
dti-3271	190	15	al	al	PROPN
dti-3271	190	16	.	.	PROPN
dti-3271	190	17	pathophysiology	pathophysiology	NOUN
dti-3271	190	18	of	of	ADP
dti-3271	190	19	type	type	NOUN
dti-3271	190	20	2	2	NUM
dti-3271	190	21	diabetes	diabetes	NOUN
dti-3271	190	22	mellitus	mellitus	NOUN
dti-3271	190	23	.	.	PUNCT
dti-3271	191	1	int	int	PROPN
dti-3271	191	2	j	j	PROPN
dti-3271	191	3	mol	mol	ADP
dti-3271	191	4	sci	sci	PROPN
dti-3271	191	5	.	.	PUNCT
dti-3271	192	1	2020;21(17):6275	2020;21(17):6275	NUM
dti-3271	192	2	.	.	PUNCT
dti-3271	192	3	crossref	crossref	PROPN
dti-3271	192	4	pubmed	pubmed	PROPN
dti-3271	192	5	3	3	PROPN
dti-3271	192	6	.	.	PUNCT
dti-3271	192	7	khan	khan	PROPN
dti-3271	192	8	mab	mab	PROPN
dti-3271	192	9	,	,	PUNCT
dti-3271	192	10	hashim	hashim	PROPN
dti-3271	192	11	mj	mj	PROPN
dti-3271	192	12	,	,	PUNCT
dti-3271	192	13	king	king	PROPN
dti-3271	192	14	jk	jk	PROPN
dti-3271	192	15	,	,	PUNCT
dti-3271	192	16	et	et	PROPN
dti-3271	192	17	al	al	PROPN
dti-3271	192	18	.	.	PUNCT
dti-3271	193	1	epidemiology	epidemiology	NOUN
dti-3271	193	2	of	of	ADP
dti-3271	193	3	type	type	NOUN
dti-3271	193	4	2	2	NUM
dti-3271	193	5	diabetes	diabetes	NOUN
dti-3271	193	6	—	—	PUNCT
dti-3271	193	7	global	global	ADJ
dti-3271	193	8	burden	burden	NOUN
dti-3271	193	9	of	of	ADP
dti-3271	193	10	disease	disease	NOUN
dti-3271	193	11	and	and	CCONJ
dti-3271	193	12	forecasted	forecast	VERB
dti-3271	193	13	trends	trend	NOUN
dti-3271	193	14	.	.	PUNCT
dti-3271	194	1	j	j	PROPN
dti-3271	194	2	epidemiol	epidemiol	PROPN
dti-3271	194	3	glob	glob	PROPN
dti-3271	194	4	health	health	NOUN
dti-3271	194	5	.	.	PUNCT
dti-3271	195	1	2020;10(1):107	2020;10(1):107	NOUN
dti-3271	195	2	-	-	SYM
dti-3271	195	3	111	111	NUM
dti-3271	195	4	.	.	PUNCT
dti-3271	196	1	crossref	crossref	PROPN
dti-3271	196	2	pubmed	pubmed	PROPN
dti-3271	196	3	4	4	PROPN
dti-3271	196	4	.	.	PUNCT
dti-3271	197	1	pozzilli	pozzilli	PROPN
dti-3271	197	2	p	p	X
dti-3271	197	3	,	,	PUNCT
dti-3271	197	4	di	di	PROPN
dti-3271	197	5	mario	mario	PROPN
dti-3271	197	6	u.	u.	PROPN
dti-3271	197	7	autoimmune	autoimmune	PROPN
dti-3271	197	8	diabetes	diabete	NOUN
dti-3271	197	9	not	not	PART
dti-3271	197	10	requiring	require	VERB
dti-3271	197	11	insulin	insulin	NOUN
dti-3271	197	12	at	at	ADP
dti-3271	197	13	diagnosis	diagnosis	NOUN
dti-3271	197	14	(	(	PUNCT
dti-3271	197	15	latent	latent	ADJ
dti-3271	197	16	autoimmune	autoimmune	ADJ
dti-3271	197	17	diabetes	diabetes	NOUN
dti-3271	197	18	of	of	ADP
dti-3271	197	19	the	the	DET
dti-3271	197	20	adult	adult	NOUN
dti-3271	197	21	):	):	PUNCT
dti-3271	197	22	definition	definition	NOUN
dti-3271	197	23	,	,	PUNCT
dti-3271	197	24	characterization	characterization	NOUN
dti-3271	197	25	,	,	PUNCT
dti-3271	197	26	and	and	CCONJ
dti-3271	197	27	potential	potential	ADJ
dti-3271	197	28	prevention	prevention	NOUN
dti-3271	197	29	.	.	PUNCT
dti-3271	198	1	diabetes	diabetes	NOUN
dti-3271	198	2	care	care	NOUN
dti-3271	198	3	.	.	PUNCT
dti-3271	199	1	2001;24(8):1460	2001;24(8):1460	NUM
dti-3271	199	2	-	-	SYM
dti-3271	199	3	1467	1467	NUM
dti-3271	199	4	.	.	PUNCT
dti-3271	200	1	crossref	crossref	PROPN
dti-3271	200	2	pubmed	pubmed	PROPN
dti-3271	200	3	5	5	PROPN
dti-3271	200	4	.	.	PUNCT
dti-3271	201	1	resnick	resnick	PROPN
dti-3271	201	2	he	he	PRON
dti-3271	201	3	,	,	PUNCT
dti-3271	201	4	howard	howard	PROPN
dti-3271	201	5	bv	bv	PROPN
dti-3271	201	6	.	.	PROPN
dti-3271	201	7	diabetes	diabetes	NOUN
dti-3271	201	8	and	and	CCONJ
dti-3271	201	9	cardiovascular	cardiovascular	ADJ
dti-3271	201	10	disease	disease	NOUN
dti-3271	201	11	.	.	PUNCT
dti-3271	202	1	annu	annu	PROPN
dti-3271	202	2	rev	rev	VERB
dti-3271	202	3	med	med	PROPN
dti-3271	202	4	.	.	PUNCT
dti-3271	203	1	2002;53(1):245	2002;53(1):245	PROPN
dti-3271	203	2	-	-	SYM
dti-3271	203	3	267	267	NUM
dti-3271	203	4	.	.	PUNCT
dti-3271	204	1	crossref	crossref	PROPN
dti-3271	204	2	pubmed	pubmed	PROPN
dti-3271	204	3	6	6	NUM
dti-3271	204	4	.	.	PUNCT
dti-3271	205	1	khursheed	khursheed	NOUN
dti-3271	205	2	r	r	NOUN
dti-3271	205	3	,	,	PUNCT
dti-3271	205	4	singh	singh	PROPN
dti-3271	205	5	sk	sk	PROPN
dti-3271	205	6	,	,	PUNCT
dti-3271	205	7	wadhwa	wadhwa	PROPN
dti-3271	205	8	s	s	PROPN
dti-3271	205	9	,	,	PUNCT
dti-3271	205	10	et	et	PROPN
dti-3271	205	11	al	al	PROPN
dti-3271	205	12	.	.	PUNCT
dti-3271	206	1	treatment	treatment	NOUN
dti-3271	206	2	strategies	strategy	NOUN
dti-3271	206	3	against	against	ADP
dti-3271	206	4	diabetes	diabetes	NOUN
dti-3271	206	5	:	:	PUNCT
dti-3271	206	6	success	success	NOUN
dti-3271	206	7	so	so	ADV
dti-3271	206	8	far	far	ADV
dti-3271	206	9	and	and	CCONJ
dti-3271	206	10	challenges	challenge	VERB
dti-3271	206	11	ahead	ahead	ADV
dti-3271	206	12	.	.	PUNCT
dti-3271	207	1	eur	eur	PROPN
dti-3271	207	2	j	j	PROPN
dti-3271	207	3	pharmacol	pharmacol	PROPN
dti-3271	207	4	.	.	PUNCT
dti-3271	208	1	2019;862:172625	2019;862:172625	NUM
dti-3271	208	2	.	.	PUNCT
dti-3271	209	1	crossref	crossref	PROPN
dti-3271	209	2	pubmed	pubmed	PROPN
dti-3271	209	3	7	7	PROPN
dti-3271	209	4	.	.	PUNCT
dti-3271	210	1	khetmalis	khetmalis	PROPN
dti-3271	210	2	ym	ym	PROPN
dti-3271	210	3	,	,	PUNCT
dti-3271	210	4	shivani	shivani	PROPN
dti-3271	210	5	m	m	PROPN
dti-3271	210	6	,	,	PUNCT
dti-3271	210	7	murugesan	murugesan	PROPN
dti-3271	210	8	s	s	PROPN
dti-3271	210	9	,	,	PUNCT
dti-3271	210	10	et	et	PROPN
dti-3271	210	11	al	al	PROPN
dti-3271	210	12	.	.	PROPN
dti-3271	210	13	oxindole	oxindole	PROPN
dti-3271	210	14	and	and	CCONJ
dti-3271	210	15	its	its	PRON
dti-3271	210	16	derivatives	derivative	NOUN
dti-3271	210	17	:	:	PUNCT
dti-3271	210	18	a	a	DET
dti-3271	210	19	review	review	NOUN
dti-3271	210	20	on	on	ADP
dti-3271	210	21	recent	recent	ADJ
dti-3271	210	22	progress	progress	NOUN
dti-3271	210	23	in	in	ADP
dti-3271	210	24	biological	biological	ADJ
dti-3271	210	25	activities	activity	NOUN
dti-3271	210	26	.	.	PUNCT
dti-3271	210	27	biomed	biome	VERB
dti-3271	210	28	pharmacother	pharmacother	ADJ
dti-3271	210	29	.	.	PUNCT
dti-3271	211	1	2021;141:111842	2021;141:111842	NUM
dti-3271	211	2	.	.	PUNCT
dti-3271	212	1	crossref	crossref	PROPN
dti-3271	212	2	pubmed	pubmed	PROPN
dti-3271	212	3	8	8	PROPN
dti-3271	212	4	.	.	PUNCT
dti-3271	213	1	gassman	gassman	PROPN
dti-3271	213	2	pg	pg	PROPN
dti-3271	213	3	,	,	PUNCT
dti-3271	213	4	van	van	PROPN
dti-3271	213	5	bergen	bergen	PROPN
dti-3271	213	6	t.	t.	PROPN
dti-3271	213	7	general	general	PROPN
dti-3271	213	8	method	method	NOUN
dti-3271	213	9	for	for	ADP
dti-3271	213	10	the	the	DET
dti-3271	213	11	synthesis	synthesis	NOUN
dti-3271	213	12	of	of	ADP
dti-3271	213	13	oxindoles	oxindole	NOUN
dti-3271	213	14	.	.	PUNCT
dti-3271	214	1	j	j	PROPN
dti-3271	214	2	am	be	AUX
dti-3271	214	3	chem	chem	NOUN
dti-3271	214	4	soc	soc	NOUN
dti-3271	214	5	.	.	PUNCT
dti-3271	215	1	1973;95(8):2718	1973;95(8):2718	PROPN
dti-3271	215	2	-	-	SYM
dti-3271	215	3	2719	2719	NUM
dti-3271	215	4	.	.	PUNCT
dti-3271	216	1	crossref	crossref	PROPN
dti-3271	216	2	9	9	NUM
dti-3271	216	3	.	.	NOUN
dti-3271	216	4	mukhliss	mukhliss	PROPN
dti-3271	216	5	l	l	PROPN
dti-3271	216	6	,	,	PUNCT
dti-3271	216	7	taha	taha	PROPN
dti-3271	216	8	m	m	PROPN
dti-3271	216	9	,	,	PUNCT
dti-3271	216	10	rahim	rahim	PROPN
dti-3271	216	11	f	f	AUX
dti-3271	216	12	,	,	PUNCT
dti-3271	216	13	et	et	PROPN
dti-3271	216	14	al	al	PROPN
dti-3271	216	15	.	.	PUNCT
dti-3271	216	16	synthesis	synthesis	NOUN
dti-3271	216	17	and	and	CCONJ
dti-3271	216	18	novel	novel	ADJ
dti-3271	216	19	structural	structural	ADJ
dti-3271	216	20	hybrid	hybrid	ADJ
dti-3271	216	21	analogs	analog	NOUN
dti-3271	216	22	of	of	ADP
dti-3271	216	23	oxindole	oxindole	NOUN
dti-3271	216	24	derivatives	derivative	NOUN
dti-3271	216	25	bearing	bear	VERB
dti-3271	216	26	piperidine	piperidine	NOUN
dti-3271	216	27	ring	ring	NOUN
dti-3271	216	28	,	,	PUNCT
dti-3271	216	29	their	their	PRON
dti-3271	216	30	antidiabetics	antidiabetic	NOUN
dti-3271	216	31	ii	ii	NOUN
dti-3271	216	32	activity	activity	NOUN
dti-3271	216	33	and	and	CCONJ
dti-3271	216	34	molecular	molecular	ADJ
dti-3271	216	35	docking	docking	NOUN
dti-3271	216	36	study	study	NOUN
dti-3271	216	37	.	.	PUNCT
dti-3271	217	1	j	j	PROPN
dti-3271	217	2	mol	mol	ADP
dti-3271	217	3	struct	struct	NOUN
dti-3271	217	4	.	.	PUNCT
dti-3271	218	1	2025;1332:141666	2025;1332:141666	NUM
dti-3271	218	2	.	.	PUNCT
dti-3271	219	1	crossref	crossref	PROPN
dti-3271	219	2	10	10	NUM
dti-3271	219	3	.	.	PUNCT
dti-3271	220	1	pirzada	pirzada	PROPN
dti-3271	220	2	as	as	ADP
dti-3271	220	3	,	,	PUNCT
dti-3271	220	4	khan	khan	PROPN
dti-3271	220	5	h	h	PROPN
dti-3271	220	6	,	,	PUNCT
dti-3271	220	7	alam	alam	PROPN
dti-3271	220	8	w	w	PROPN
dti-3271	220	9	,	,	PUNCT
dti-3271	220	10	et	et	PROPN
dti-3271	220	11	al	al	PROPN
dti-3271	220	12	.	.	PUNCT
dti-3271	220	13	physicochemical	physicochemical	ADJ
dti-3271	220	14	properties	property	NOUN
dti-3271	220	15	,	,	PUNCT
dti-3271	220	16	pharmacokinetic	pharmacokinetic	ADJ
dti-3271	220	17	studies	study	NOUN
dti-3271	220	18	,	,	PUNCT
dti-3271	220	19	dft	dft	PROPN
dti-3271	220	20	approach	approach	NOUN
dti-3271	220	21	,	,	PUNCT
dti-3271	220	22	and	and	CCONJ
dti-3271	220	23	antioxidant	antioxidant	ADJ
dti-3271	220	24	activity	activity	NOUN
dti-3271	220	25	of	of	ADP
dti-3271	220	26	nitro	nitro	NOUN
dti-3271	220	27	and	and	CCONJ
dti-3271	220	28	chloro	chloro	NOUN
dti-3271	220	29	indolinone	indolinone	NOUN
dti-3271	220	30	derivatives	derivative	NOUN
dti-3271	220	31	.	.	PUNCT
dti-3271	221	1	front	front	ADJ
dti-3271	221	2	chem	chem	NOUN
dti-3271	221	3	.	.	PUNCT
dti-3271	222	1	2024;12:1360719	2024;12:1360719	NUM
dti-3271	222	2	.	.	PUNCT
dti-3271	223	1	crossref	crossref	PROPN
dti-3271	223	2	pubmed	pubmed	PROPN
dti-3271	223	3	11	11	NUM
dti-3271	223	4	.	.	PUNCT
dti-3271	224	1	ahmad	ahmad	PROPN
dti-3271	224	2	i	i	PRON
dti-3271	224	3	,	,	PUNCT
dti-3271	224	4	khan	khan	PROPN
dti-3271	224	5	h	h	PROPN
dti-3271	224	6	,	,	PUNCT
dti-3271	224	7	serdaroğlu	serdaroğlu	PROPN
dti-3271	224	8	g.	g.	PROPN
dti-3271	224	9	physicochemical	physicochemical	ADJ
dti-3271	224	10	properties	property	NOUN
dti-3271	224	11	,	,	PUNCT
dti-3271	224	12	drug	drug	NOUN
dti-3271	224	13	likeness	likeness	NOUN
dti-3271	224	14	,	,	PUNCT
dti-3271	224	15	admet	admet	PROPN
dti-3271	224	16	,	,	PUNCT
dti-3271	224	17	dft	dft	PROPN
dti-3271	224	18	studies	study	NOUN
dti-3271	224	19	,	,	PUNCT
dti-3271	224	20	and	and	CCONJ
dti-3271	224	21	in	in	ADP
dti-3271	224	22	vitro	vitro	X
dti-3271	224	23	antioxidant	antioxidant	ADJ
dti-3271	224	24	activity	activity	NOUN
dti-3271	224	25	of	of	ADP
dti-3271	224	26	oxindole	oxindole	NOUN
dti-3271	224	27	derivatives	derivative	NOUN
dti-3271	224	28	.	.	PUNCT
dti-3271	225	1	comput	comput	VERB
dti-3271	225	2	biol	biol	PROPN
dti-3271	225	3	chem	chem	NOUN
dti-3271	225	4	.	.	PUNCT
dti-3271	226	1	2023;104:107861	2023;104:107861	NUM
dti-3271	226	2	.	.	PUNCT
dti-3271	227	1	crossref	crossref	PROPN
dti-3271	227	2	pubmed	pubmed	PROPN
dti-3271	227	3	12	12	NUM
dti-3271	227	4	.	.	PUNCT
dti-3271	228	1	kadhim	kadhim	PROPN
dti-3271	228	2	mm	mm	PROPN
dti-3271	228	3	,	,	PUNCT
dti-3271	228	4	heravi	heravi	PROPN
dti-3271	228	5	mrp	mrp	NOUN
dti-3271	228	6	,	,	PUNCT
dti-3271	228	7	mohammadi	mohammadi	NOUN
dti-3271	228	8	-	-	PUNCT
dti-3271	228	9	aghdam	aghdam	NOUN
dti-3271	228	10	s	s	PROPN
dti-3271	228	11	,	,	PUNCT
dti-3271	228	12	et	et	PROPN
dti-3271	228	13	al	al	PROPN
dti-3271	228	14	.	.	PROPN
dti-3271	228	15	investigation	investigation	NOUN
dti-3271	228	16	of	of	ADP
dti-3271	228	17	anti	anti	ADJ
dti-3271	228	18	-	-	ADJ
dti-3271	228	19	tumor	tumor	ADJ
dti-3271	228	20	(	(	PUNCT
dti-3271	228	21	e)-3	e)-3	NOUN
dti-3271	228	22	-	-	PUNCT
dti-3271	228	23	x	x	NOUN
dti-3271	228	24	-	-	NOUN
dti-3271	228	25	oxindole	oxindole	NOUN
dti-3271	228	26	via	via	ADP
dti-3271	228	27	functionalization	functionalization	NOUN
dti-3271	228	28	of	of	ADP
dti-3271	228	29	c20	c20	NOUN
dti-3271	228	30	nano	nano	NOUN
dti-3271	228	31	structure	structure	NOUN
dti-3271	228	32	:	:	PUNCT
dti-3271	228	33	a	a	DET
dti-3271	228	34	dft	dft	PROPN
dti-3271	228	35	approach	approach	NOUN
dti-3271	228	36	.	.	PUNCT
dti-3271	229	1	comput	comput	PROPN
dti-3271	229	2	theor	theor	PROPN
dti-3271	229	3	chem	chem	NOUN
dti-3271	229	4	.	.	PUNCT
dti-3271	230	1	2022;1214:113763	2022;1214:113763	NUM
dti-3271	230	2	.	.	PUNCT
dti-3271	231	1	crossref	crossref	PROPN
dti-3271	231	2	13	13	NUM
dti-3271	231	3	.	.	PUNCT
dti-3271	232	1	khan	khan	PROPN
dti-3271	232	2	m	m	PROPN
dti-3271	232	3	,	,	PUNCT
dti-3271	232	4	yousaf	yousaf	PROPN
dti-3271	232	5	m	m	PROPN
dti-3271	232	6	,	,	PUNCT
dti-3271	232	7	wadood	wadood	PROPN
dti-3271	232	8	a	a	X
dti-3271	232	9	,	,	PUNCT
dti-3271	232	10	et	et	PROPN
dti-3271	232	11	al	al	PROPN
dti-3271	232	12	.	.	PROPN
dti-3271	232	13	discovery	discovery	PROPN
dti-3271	232	14	of	of	ADP
dti-3271	232	15	novel	novel	ADJ
dti-3271	232	16	oxindole	oxindole	NOUN
dti-3271	232	17	derivatives	derivative	NOUN
dti-3271	232	18	as	as	ADP
dti-3271	232	19	potent	potent	ADJ
dti-3271	232	20	α	α	NOUN
dti-3271	232	21	-	-	PUNCT
dti-3271	232	22	glucosidase	glucosidase	ADJ
dti-3271	232	23	inhibitors	inhibitor	NOUN
dti-3271	232	24	.	.	PUNCT
dti-3271	233	1	bioorg	bioorg	PROPN
dti-3271	233	2	med	med	PROPN
dti-3271	233	3	chem	chem	NOUN
dti-3271	233	4	.	.	PUNCT
dti-3271	234	1	2014;22(13):3441	2014;22(13):3441	NUM
dti-3271	234	2	-	-	SYM
dti-3271	234	3	3448	3448	NUM
dti-3271	234	4	.	.	PUNCT
dti-3271	235	1	crossref	crossref	PROPN
dti-3271	235	2	pubmed	pubmed	PROPN
dti-3271	235	3	https://doi.org/10.1155/2018/4170372	https://doi.org/10.1155/2018/4170372	PROPN
dti-3271	236	1	https://pubmed.ncbi.nlm.nih.gov/30108655/	https://pubmed.ncbi.nlm.nih.gov/30108655/	PROPN
dti-3271	236	2	https://doi.org/10.3390/ijms21176275	https://doi.org/10.3390/ijms21176275	PROPN
dti-3271	236	3	https://pubmed.ncbi.nlm.nih.gov/32872570	https://pubmed.ncbi.nlm.nih.gov/32872570	PROPN
dti-3271	236	4	https://doi.org/10.2991/jegh.k.191028.001	https://doi.org/10.2991/jegh.k.191028.001	VERB
dti-3271	236	5	https://pubmed.ncbi.nlm.nih.gov/32175717	https://pubmed.ncbi.nlm.nih.gov/32175717	ADV
dti-3271	236	6	https://doi.org/10.2337/diacare.24.8.1460	https://doi.org/10.2337/diacare.24.8.1460	ADJ
dti-3271	236	7	https://pubmed.ncbi.nlm.nih.gov/11473087	https://pubmed.ncbi.nlm.nih.gov/11473087	NOUN
dti-3271	236	8	https://doi.org/10.1146/annurev.med.53.082901.103904	https://doi.org/10.1146/annurev.med.53.082901.103904	PROPN
dti-3271	236	9	https://pubmed.ncbi.nlm.nih.gov/11818473	https://pubmed.ncbi.nlm.nih.gov/11818473	PROPN
dti-3271	236	10	https://doi.org/10.1016/j.ejphar.2019.172625	https://doi.org/10.1016/j.ejphar.2019.172625	PROPN
dti-3271	236	11	https://pubmed.ncbi.nlm.nih.gov/31449807	https://pubmed.ncbi.nlm.nih.gov/31449807	PROPN
dti-3271	236	12	https://doi.org/10.1016/j.biopha.2021.111842	https://doi.org/10.1016/j.biopha.2021.111842	NOUN
dti-3271	236	13	https://pubmed.ncbi.nlm.nih.gov/34174506	https://pubmed.ncbi.nlm.nih.gov/34174506	PROPN
dti-3271	236	14	https://doi.org/10.1021/ja00789a070	https://doi.org/10.1021/ja00789a070	PROPN
dti-3271	236	15	https://doi:10.1016	https://doi:10.1016	PROPN
dti-3271	236	16	/	/	SYM
dti-3271	236	17	j.molstruc.2025.141666	j.molstruc.2025.141666	NOUN
dti-3271	236	18	https://doi.org/10.3389/fchem.2024.1360719	https://doi.org/10.3389/fchem.2024.1360719	PROPN
dti-3271	236	19	https://pubmed.ncbi.nlm.nih.gov/38562526	https://pubmed.ncbi.nlm.nih.gov/38562526	PROPN
dti-3271	236	20	https://doi.org/10.1016/j.compbiolchem.2023.107861	https://doi.org/10.1016/j.compbiolchem.2023.107861	PROPN
dti-3271	236	21	https://pubmed.ncbi.nlm.nih.gov/37060784	https://pubmed.ncbi.nlm.nih.gov/37060784	VERB
dti-3271	236	22	https://doi:10.1016	https://doi:10.1016	PROPN
dti-3271	236	23	/	/	SYM
dti-3271	236	24	j.comptc.2022.113763	j.comptc.2022.113763	PROPN
dti-3271	236	25	https://doi.org/10.1016/j.bmc.2014.04.033	https://doi.org/10.1016/j.bmc.2014.04.033	PROPN
dti-3271	236	26	https://pubmed.ncbi.nlm.nih.gov/24825482	https://pubmed.ncbi.nlm.nih.gov/24825482	PROPN
dti-3271	236	27	rauf	rauf	PROPN
dti-3271	236	28	et	et	PROPN
dti-3271	236	29	al	al	PROPN
dti-3271	236	30	drug	drug	PROPN
dti-3271	236	31	target	target	NOUN
dti-3271	236	32	insights	insight	NOUN
dti-3271	236	33	2025	2025	NUM
dti-3271	236	34	;	;	PUNCT
dti-3271	236	35	19	19	NUM
dti-3271	236	36	:	:	SYM
dti-3271	236	37	17	17	NUM
dti-3271	236	38	©	©	PROPN
dti-3271	236	39	2025	2025	NUM
dti-3271	236	40	the	the	DET
dti-3271	236	41	authors	author	NOUN
dti-3271	236	42	.	.	PUNCT
dti-3271	237	1	published	publish	VERB
dti-3271	237	2	by	by	ADP
dti-3271	237	3	aboutscience	aboutscience	NOUN
dti-3271	237	4	www.aboutscience.eu	www.aboutscience.eu	PROPN
dti-3271	237	5	14	14	NUM
dti-3271	237	6	.	.	PUNCT
dti-3271	238	1	altowyan	altowyan	PROPN
dti-3271	238	2	ms	ms	PROPN
dti-3271	238	3	,	,	PUNCT
dti-3271	238	4	barakat	barakat	PROPN
dti-3271	238	5	a	a	PROPN
dti-3271	238	6	,	,	PUNCT
dti-3271	238	7	al	al	PROPN
dti-3271	238	8	-	-	PUNCT
dti-3271	238	9	majid	majid	PROPN
dti-3271	238	10	am	am	PROPN
dti-3271	238	11	,	,	PUNCT
dti-3271	238	12	et	et	PROPN
dti-3271	238	13	al	al	PROPN
dti-3271	238	14	.	.	PUNCT
dti-3271	239	1	spiroindolone	spiroindolone	PROPN
dti-3271	239	2	analogues	analogue	NOUN
dti-3271	239	3	as	as	ADP
dti-3271	239	4	potential	potential	ADJ
dti-3271	239	5	hypoglycemic	hypoglycemic	ADJ
dti-3271	239	6	with	with	ADP
dti-3271	239	7	dual	dual	ADJ
dti-3271	239	8	inhibitory	inhibitory	ADJ
dti-3271	239	9	activity	activity	NOUN
dti-3271	239	10	on	on	ADP
dti-3271	239	11	α	α	NOUN
dti-3271	239	12	-	-	NOUN
dti-3271	239	13	amylase	amylase	NOUN
dti-3271	239	14	and	and	CCONJ
dti-3271	239	15	α	α	NOUN
dti-3271	239	16	-	-	PUNCT
dti-3271	239	17	glucosidase	glucosidase	ADJ
dti-3271	239	18	.	.	PUNCT
dti-3271	240	1	molecules	molecule	NOUN
dti-3271	240	2	.	.	PUNCT
dti-3271	241	1	2019	2019	NUM
dti-3271	241	2	;	;	PUNCT
dti-3271	242	1	24(12):2342	24(12):2342	NUM
dti-3271	242	2	.	.	PUNCT
dti-3271	243	1	crossref	crossref	PROPN
dti-3271	243	2	pubmed	pubmed	PROPN
dti-3271	243	3	15	15	PROPN
dti-3271	243	4	.	.	PUNCT
dti-3271	244	1	rauf	rauf	PROPN
dti-3271	244	2	a	a	PROPN
dti-3271	244	3	,	,	PUNCT
dti-3271	244	4	khan	khan	PROPN
dti-3271	244	5	h	h	PROPN
dti-3271	244	6	,	,	PUNCT
dti-3271	244	7	khan	khan	PROPN
dti-3271	244	8	m	m	PROPN
dti-3271	244	9	,	,	PUNCT
dti-3271	244	10	et	et	PROPN
dti-3271	244	11	al	al	PROPN
dti-3271	244	12	.	.	PROPN
dti-3271	245	1	in	in	ADP
dti-3271	245	2	silico	silico	NOUN
dti-3271	245	3	,	,	PUNCT
dti-3271	245	4	swiss	swiss	ADJ
dti-3271	245	5	adme	adme	NOUN
dti-3271	245	6	,	,	PUNCT
dti-3271	245	7	and	and	CCONJ
dti-3271	245	8	dft	dft	PROPN
dti-3271	245	9	studies	study	NOUN
dti-3271	245	10	of	of	ADP
dti-3271	245	11	newly	newly	ADV
dti-3271	245	12	synthesized	synthesize	VERB
dti-3271	245	13	oxindole	oxindole	NOUN
dti-3271	245	14	derivatives	derivative	NOUN
dti-3271	245	15	followed	follow	VERB
dti-3271	245	16	by	by	ADP
dti-3271	245	17	antioxidant	antioxidant	ADJ
dti-3271	245	18	studies	study	NOUN
dti-3271	245	19	.	.	PUNCT
dti-3271	246	1	j	j	PROPN
dti-3271	246	2	chem	chem	NOUN
dti-3271	246	3	.	.	PUNCT
dti-3271	247	1	2023;2023(1):5553913	2023;2023(1):5553913	NUM
dti-3271	247	2	.	.	PUNCT
dti-3271	248	1	crossref	crossref	PROPN
dti-3271	248	2	16	16	NUM
dti-3271	248	3	.	.	PUNCT
dti-3271	249	1	huneif	huneif	PROPN
dti-3271	249	2	ma	ma	PROPN
dti-3271	249	3	,	,	PUNCT
dti-3271	249	4	alshehri	alshehri	PROPN
dti-3271	249	5	db	db	PROPN
dti-3271	249	6	,	,	PUNCT
dti-3271	249	7	alshaibari	alshaibari	ADJ
dti-3271	249	8	ks	ks	PROPN
dti-3271	249	9	,	,	PUNCT
dti-3271	249	10	et	et	PROPN
dti-3271	249	11	al	al	PROPN
dti-3271	249	12	.	.	PROPN
dti-3271	249	13	design	design	NOUN
dti-3271	249	14	,	,	PUNCT
dti-3271	249	15	synthesis	synthesis	NOUN
dti-3271	249	16	and	and	CCONJ
dti-3271	249	17	bioevaluation	bioevaluation	NOUN
dti-3271	249	18	of	of	ADP
dti-3271	249	19	new	new	ADJ
dti-3271	249	20	vanillin	vanillin	NOUN
dti-3271	249	21	hybrid	hybrid	NOUN
dti-3271	249	22	as	as	ADP
dti-3271	249	23	multitarget	multitarget	PROPN
dti-3271	249	24	inhibitor	inhibitor	NOUN
dti-3271	249	25	of	of	ADP
dti-3271	249	26	α	α	NOUN
dti-3271	249	27	-	-	PUNCT
dti-3271	249	28	glucosidase	glucosidase	ADJ
dti-3271	249	29	,	,	PUNCT
dti-3271	249	30	α	α	NOUN
dti-3271	249	31	-	-	NOUN
dti-3271	249	32	amylase	amylase	NOUN
dti-3271	249	33	,	,	PUNCT
dti-3271	249	34	ptp-1b	ptp-1b	NOUN
dti-3271	249	35	and	and	CCONJ
dti-3271	249	36	dpp4	dpp4	PROPN
dti-3271	249	37	for	for	ADP
dti-3271	249	38	the	the	DET
dti-3271	249	39	treatment	treatment	NOUN
dti-3271	249	40	of	of	ADP
dti-3271	249	41	type	type	NOUN
dti-3271	249	42	-	-	PUNCT
dti-3271	249	43	ii	ii	NOUN
dti-3271	249	44	diabetes	diabetes	NOUN
dti-3271	249	45	.	.	PUNCT
dti-3271	249	46	biomed	biome	VERB
dti-3271	249	47	pharmacother	pharmacother	ADJ
dti-3271	249	48	.	.	PUNCT
dti-3271	250	1	2022;150:113038	2022;150:113038	X
dti-3271	250	2	.	.	PUNCT
dti-3271	251	1	crossref	crossref	PROPN
dti-3271	251	2	pubmed	pubmed	PROPN
dti-3271	251	3	17	17	NUM
dti-3271	251	4	.	.	PUNCT
dti-3271	252	1	taha	taha	PROPN
dti-3271	252	2	m	m	PROPN
dti-3271	252	3	,	,	PUNCT
dti-3271	252	4	ismail	ismail	PROPN
dti-3271	252	5	nh	nh	PROPN
dti-3271	252	6	,	,	PUNCT
dti-3271	252	7	khan	khan	PROPN
dti-3271	252	8	a	a	PROPN
dti-3271	252	9	,	,	PUNCT
dti-3271	252	10	et	et	PROPN
dti-3271	252	11	al	al	PROPN
dti-3271	252	12	.	.	PUNCT
dti-3271	252	13	synthesis	synthesis	NOUN
dti-3271	252	14	of	of	ADP
dti-3271	252	15	novel	novel	ADJ
dti-3271	252	16	derivatives	derivative	NOUN
dti-3271	252	17	of	of	ADP
dti-3271	252	18	oxindole	oxindole	NOUN
dti-3271	252	19	,	,	PUNCT
dti-3271	252	20	their	their	PRON
dti-3271	252	21	urease	urease	NOUN
dti-3271	252	22	inhibition	inhibition	NOUN
dti-3271	252	23	and	and	CCONJ
dti-3271	252	24	molecular	molecular	ADJ
dti-3271	252	25	docking	docking	NOUN
dti-3271	252	26	studies	study	NOUN
dti-3271	252	27	.	.	PUNCT
dti-3271	253	1	bioorg	bioorg	PROPN
dti-3271	253	2	med	med	PROPN
dti-3271	253	3	chem	chem	NOUN
dti-3271	253	4	lett	lett	PROPN
dti-3271	253	5	.	.	PUNCT
dti-3271	254	1	2015;25(16):3285	2015;25(16):3285	NUM
dti-3271	254	2	-	-	SYM
dti-3271	254	3	3289	3289	NUM
dti-3271	254	4	.	.	PUNCT
dti-3271	255	1	crossref	crossref	PROPN
dti-3271	255	2	pubmed	pubmed	PROPN
dti-3271	255	3	18	18	NUM
dti-3271	255	4	.	.	PUNCT
dti-3271	256	1	irfan	irfan	PROPN
dti-3271	256	2	a	a	X
dti-3271	256	3	,	,	PUNCT
dti-3271	256	4	faisal	faisal	PROPN
dti-3271	256	5	s	s	PROPN
dti-3271	256	6	,	,	PUNCT
dti-3271	256	7	ahmad	ahmad	PROPN
dti-3271	256	8	s	s	PROPN
dti-3271	256	9	,	,	PUNCT
dti-3271	256	10	et	et	PROPN
dti-3271	256	11	al	al	PROPN
dti-3271	256	12	.	.	PROPN
dti-3271	256	13	structure	structure	NOUN
dti-3271	256	14	-	-	PUNCT
dti-3271	256	15	based	base	VERB
dti-3271	256	16	virtual	virtual	ADJ
dti-3271	256	17	screening	screening	NOUN
dti-3271	256	18	of	of	ADP
dti-3271	256	19	furan-1	furan-1	PROPN
dti-3271	256	20	,	,	PUNCT
dti-3271	256	21	3	3	NUM
dti-3271	256	22	,	,	PUNCT
dti-3271	256	23	4	4	NUM
dti-3271	256	24	-	-	PUNCT
dti-3271	256	25	oxadiazole	oxadiazole	NOUN
dti-3271	256	26	tethered	tethered	ADJ
dti-3271	256	27	n	n	CCONJ
dti-3271	256	28	-	-	PUNCT
dti-3271	256	29	phenylacetamide	phenylacetamide	NOUN
dti-3271	256	30	derivatives	derivative	NOUN
dti-3271	256	31	as	as	ADP
dti-3271	256	32	novel	novel	ADJ
dti-3271	256	33	class	class	NOUN
dti-3271	256	34	of	of	ADP
dti-3271	256	35	htyr	htyr	NOUN
dti-3271	256	36	and	and	CCONJ
dti-3271	256	37	htyrp1	htyrp1	NOUN
dti-3271	256	38	inhibitors	inhibitor	NOUN
dti-3271	256	39	.	.	PUNCT
dti-3271	257	1	pharmaceuticals	pharmaceutical	NOUN
dti-3271	257	2	,	,	PUNCT
dti-3271	257	3	2023	2023	NUM
dti-3271	257	4	,	,	PUNCT
dti-3271	257	5	16	16	NUM
dti-3271	257	6	,	,	PUNCT
dti-3271	257	7	(	(	PUNCT
dti-3271	257	8	3	3	NUM
dti-3271	257	9	)	)	PUNCT
dti-3271	257	10	,	,	PUNCT
dti-3271	257	11	344	344	NUM
dti-3271	257	12	.	.	PUNCT
dti-3271	258	1	crossref	crossref	PROPN
dti-3271	258	2	19	19	NUM
dti-3271	258	3	.	.	PUNCT
dti-3271	258	4	nahoum	nahoum	PROPN
dti-3271	258	5	v	v	NOUN
dti-3271	258	6	,	,	PUNCT
dti-3271	258	7	roux	roux	NOUN
dti-3271	258	8	g	g	NOUN
dti-3271	258	9	,	,	PUNCT
dti-3271	258	10	anton	anton	NOUN
dti-3271	258	11	v	v	NOUN
dti-3271	258	12	,	,	PUNCT
dti-3271	258	13	et	et	PROPN
dti-3271	258	14	al	al	PROPN
dti-3271	258	15	.	.	PUNCT
dti-3271	259	1	crystal	crystal	NOUN
dti-3271	259	2	structures	structure	NOUN
dti-3271	259	3	of	of	ADP
dti-3271	259	4	human	human	ADJ
dti-3271	259	5	pancreatic	pancreatic	ADJ
dti-3271	259	6	α	α	NOUN
dti-3271	259	7	-	-	NOUN
dti-3271	259	8	amylase	amylase	NOUN
dti-3271	259	9	in	in	ADP
dti-3271	259	10	complex	complex	NOUN
dti-3271	259	11	with	with	ADP
dti-3271	259	12	carbohydrate	carbohydrate	NOUN
dti-3271	259	13	and	and	CCONJ
dti-3271	259	14	proteinaceous	proteinaceous	ADJ
dti-3271	259	15	inhibitors	inhibitor	NOUN
dti-3271	259	16	.	.	PUNCT
dti-3271	260	1	biochem	biochem	PROPN
dti-3271	260	2	j.	j.	PROPN
dti-3271	261	1	2000;346(pt	2000;346(pt	PROPN
dti-3271	261	2	1):201	1):201	PROPN
dti-3271	261	3	-	-	SYM
dti-3271	261	4	208	208	NUM
dti-3271	261	5	.	.	PUNCT
dti-3271	262	1	crossref	crossref	PROPN
dti-3271	262	2	pubmed	pubmed	PROPN
dti-3271	262	3	20	20	NUM
dti-3271	262	4	.	.	PUNCT
dti-3271	263	1	yamamoto	yamamoto	PROPN
dti-3271	263	2	k	k	PROPN
dti-3271	263	3	,	,	PUNCT
dti-3271	263	4	miyake	miyake	PROPN
dti-3271	263	5	h	h	PROPN
dti-3271	263	6	,	,	PUNCT
dti-3271	263	7	kusunoki	kusunoki	PROPN
dti-3271	263	8	m	m	PROPN
dti-3271	263	9	,	,	PUNCT
dti-3271	263	10	et	et	PROPN
dti-3271	263	11	al	al	PROPN
dti-3271	263	12	.	.	PUNCT
dti-3271	264	1	crystal	crystal	NOUN
dti-3271	264	2	structures	structure	NOUN
dti-3271	264	3	of	of	ADP
dti-3271	264	4	isomaltase	isomaltase	NOUN
dti-3271	264	5	from	from	ADP
dti-3271	264	6	saccharomyces	saccharomyce	NOUN
dti-3271	264	7	cerevisiae	cerevisiae	NOUN
dti-3271	264	8	and	and	CCONJ
dti-3271	264	9	in	in	ADP
dti-3271	264	10	complex	complex	NOUN
dti-3271	264	11	with	with	ADP
dti-3271	264	12	its	its	PRON
dti-3271	264	13	competitive	competitive	ADJ
dti-3271	264	14	inhibitor	inhibitor	NOUN
dti-3271	264	15	maltose	maltose	PROPN
dti-3271	264	16	.	.	PUNCT
dti-3271	265	1	febs	febs	PROPN
dti-3271	265	2	j.	j.	PROPN
dti-3271	265	3	2010;277(20	2010;277(20	PROPN
dti-3271	265	4	):	):	PUNCT
dti-3271	265	5	4205	4205	NUM
dti-3271	265	6	-	-	SYM
dti-3271	265	7	4214	4214	NUM
dti-3271	265	8	.	.	PUNCT
dti-3271	266	1	crossref	crossref	PROPN
dti-3271	266	2	pubmed	pubmed	PROPN
dti-3271	266	3	21	21	NUM
dti-3271	266	4	.	.	PUNCT
dti-3271	267	1	schenone	schenone	PROPN
dti-3271	267	2	m	m	PROPN
dti-3271	267	3	,	,	PUNCT
dti-3271	267	4	dančík	dančík	NOUN
dti-3271	267	5	v	v	NOUN
dti-3271	267	6	,	,	PUNCT
dti-3271	267	7	wagner	wagner	PROPN
dti-3271	267	8	bk	bk	PROPN
dti-3271	267	9	,	,	PUNCT
dti-3271	267	10	et	et	PROPN
dti-3271	267	11	al	al	PROPN
dti-3271	267	12	.	.	PROPN
dti-3271	267	13	target	target	NOUN
dti-3271	267	14	identification	identification	NOUN
dti-3271	267	15	and	and	CCONJ
dti-3271	267	16	mechanism	mechanism	NOUN
dti-3271	267	17	of	of	ADP
dti-3271	267	18	action	action	NOUN
dti-3271	267	19	in	in	ADP
dti-3271	267	20	chemical	chemical	ADJ
dti-3271	267	21	biology	biology	NOUN
dti-3271	267	22	and	and	CCONJ
dti-3271	267	23	drug	drug	NOUN
dti-3271	267	24	discovery	discovery	NOUN
dti-3271	267	25	.	.	PUNCT
dti-3271	268	1	nat	nat	PROPN
dti-3271	268	2	chem	chem	PROPN
dti-3271	268	3	biol	biol	PROPN
dti-3271	268	4	.	.	PUNCT
dti-3271	269	1	2013;9(4):232	2013;9(4):232	X
dti-3271	269	2	-	-	SYM
dti-3271	269	3	240	240	NUM
dti-3271	269	4	.	.	PUNCT
dti-3271	270	1	crossref	crossref	PROPN
dti-3271	270	2	pubmed	pubmed	PROPN
dti-3271	270	3	22	22	NUM
dti-3271	270	4	.	.	PUNCT
dti-3271	271	1	rindhe	rindhe	PROPN
dti-3271	271	2	ss	ss	PROPN
dti-3271	271	3	,	,	PUNCT
dti-3271	271	4	karale	karale	NOUN
dti-3271	271	5	bk	bk	PROPN
dti-3271	271	6	,	,	PUNCT
dti-3271	271	7	gupta	gupta	PROPN
dti-3271	271	8	rc	rc	PROPN
dti-3271	271	9	,	,	PUNCT
dti-3271	271	10	et	et	PROPN
dti-3271	271	11	al	al	PROPN
dti-3271	271	12	.	.	PUNCT
dti-3271	271	13	synthesis	synthesis	NOUN
dti-3271	271	14	,	,	PUNCT
dti-3271	271	15	antimicrobial	antimicrobial	ADJ
dti-3271	271	16	and	and	CCONJ
dti-3271	271	17	antioxidant	antioxidant	ADJ
dti-3271	271	18	activity	activity	NOUN
dti-3271	271	19	of	of	ADP
dti-3271	271	20	some	some	DET
dti-3271	271	21	oxindoles	oxindole	NOUN
dti-3271	271	22	.	.	PUNCT
dti-3271	272	1	indian	indian	PROPN
dti-3271	272	2	j	j	PROPN
dti-3271	272	3	pharm	pharm	PROPN
dti-3271	272	4	sci	sci	PROPN
dti-3271	272	5	.	.	PUNCT
dti-3271	272	6	2011;73(3):292	2011;73(3):292	NUM
dti-3271	272	7	-	-	PUNCT
dti-3271	272	8	296	296	NUM
dti-3271	272	9	.	.	PUNCT
dti-3271	272	10	pubmed	pubmed	PROPN
dti-3271	272	11	23	23	NUM
dti-3271	272	12	.	.	PUNCT
dti-3271	273	1	qi	qi	PROPN
dti-3271	273	2	y	y	PROPN
dti-3271	273	3	,	,	PUNCT
dti-3271	273	4	gong	gong	PROPN
dti-3271	273	5	h	h	PROPN
dti-3271	273	6	,	,	PUNCT
dti-3271	273	7	wang	wang	PROPN
dti-3271	273	8	z	z	PROPN
dti-3271	273	9	,	,	PUNCT
dti-3271	274	1	et	et	PROPN
dti-3271	274	2	al	al	PROPN
dti-3271	274	3	.	.	PROPN
dti-3271	274	4	discovery	discovery	PROPN
dti-3271	274	5	of	of	ADP
dti-3271	274	6	novel	novel	ADJ
dti-3271	274	7	oxindole	oxindole	NOUN
dti-3271	274	8	derivatives	derivative	NOUN
dti-3271	274	9	as	as	ADP
dti-3271	274	10	trpa1	trpa1	NOUN
dti-3271	274	11	antagonists	antagonist	NOUN
dti-3271	274	12	with	with	ADP
dti-3271	274	13	potent	potent	ADJ
dti-3271	274	14	analgesic	analgesic	ADJ
dti-3271	274	15	activity	activity	NOUN
dti-3271	274	16	for	for	ADP
dti-3271	274	17	pain	pain	NOUN
dti-3271	274	18	treatment	treatment	NOUN
dti-3271	274	19	.	.	PUNCT
dti-3271	275	1	bioorganic	bioorganic	ADJ
dti-3271	275	2	chemistry	chemistry	NOUN
dti-3271	275	3	154	154	NUM
dti-3271	275	4	,	,	PUNCT
dti-3271	275	5	108088	108088	NUM
dti-3271	275	6	.	.	PUNCT
dti-3271	276	1	24	24	NUM
dti-3271	276	2	.	.	PUNCT
dti-3271	276	3	casirola	casirola	PROPN
dti-3271	276	4	dm	dm	PROPN
dti-3271	276	5	,	,	PUNCT
dti-3271	276	6	ferraris	ferraris	PROPN
dti-3271	276	7	rp	rp	PROPN
dti-3271	276	8	.	.	PUNCT
dti-3271	277	1	α	α	X
dti-3271	277	2	-	-	ADJ
dti-3271	277	3	glucosidase	glucosidase	ADJ
dti-3271	277	4	inhibitors	inhibitor	NOUN
dti-3271	277	5	prevent	prevent	VERB
dti-3271	277	6	diet	diet	NOUN
dti-3271	277	7	-	-	PUNCT
dti-3271	277	8	induced	induce	VERB
dti-3271	277	9	increases	increase	NOUN
dti-3271	277	10	in	in	ADP
dti-3271	277	11	intestinal	intestinal	ADJ
dti-3271	277	12	sugar	sugar	NOUN
dti-3271	277	13	transport	transport	NOUN
dti-3271	277	14	in	in	ADP
dti-3271	277	15	diabetic	diabetic	ADJ
dti-3271	277	16	mice	mouse	NOUN
dti-3271	277	17	.	.	PUNCT
dti-3271	278	1	metabolism	metabolism	NOUN
dti-3271	278	2	.	.	PUNCT
dti-3271	279	1	2006;55(6):832	2006;55(6):832	NUM
dti-3271	279	2	-	-	SYM
dti-3271	279	3	841	841	NUM
dti-3271	279	4	.	.	PUNCT
dti-3271	280	1	crossref	crossref	PROPN
dti-3271	280	2	pubmed	pubmed	PROPN
dti-3271	280	3	25	25	NUM
dti-3271	280	4	.	.	PUNCT
dti-3271	281	1	derosa	derosa	PROPN
dti-3271	281	2	g	g	PROPN
dti-3271	281	3	,	,	PUNCT
dti-3271	281	4	maffioli	maffioli	PROPN
dti-3271	281	5	p.	p.	NOUN
dti-3271	281	6	α	α	NOUN
dti-3271	281	7	-	-	ADJ
dti-3271	281	8	glucosidase	glucosidase	ADJ
dti-3271	281	9	inhibitors	inhibitor	NOUN
dti-3271	281	10	and	and	CCONJ
dti-3271	281	11	their	their	PRON
dti-3271	281	12	use	use	NOUN
dti-3271	281	13	in	in	ADP
dti-3271	281	14	clinical	clinical	ADJ
dti-3271	281	15	practice	practice	NOUN
dti-3271	281	16	.	.	PUNCT
dti-3271	282	1	arch	arch	PROPN
dti-3271	282	2	med	med	PROPN
dti-3271	282	3	sci	sci	PROPN
dti-3271	282	4	.	.	PUNCT
dti-3271	283	1	2012;8(5):899	2012;8(5):899	X
dti-3271	283	2	-	-	PUNCT
dti-3271	283	3	906	906	NUM
dti-3271	283	4	.	.	PUNCT
dti-3271	284	1	crossref	crossref	PROPN
dti-3271	284	2	pubmed	pubmed	PROPN
dti-3271	284	3	26	26	NUM
dti-3271	284	4	.	.	PUNCT
dti-3271	285	1	thilagam	thilagam	PROPN
dti-3271	285	2	e	e	NOUN
dti-3271	285	3	,	,	PUNCT
dti-3271	285	4	parimaladevi	parimaladevi	PROPN
dti-3271	285	5	b	b	NOUN
dti-3271	285	6	,	,	PUNCT
dti-3271	285	7	kumarappan	kumarappan	NOUN
dti-3271	285	8	c	c	NOUN
dti-3271	285	9	,	,	PUNCT
dti-3271	285	10	et	et	PROPN
dti-3271	285	11	al	al	PROPN
dti-3271	285	12	.	.	PUNCT
dti-3271	286	1	α	α	PROPN
dti-3271	286	2	-	-	PUNCT
dti-3271	286	3	glucosidase	glucosidase	ADJ
dti-3271	286	4	and	and	CCONJ
dti-3271	286	5	α	α	NOUN
dti-3271	286	6	-	-	PUNCT
dti-3271	286	7	amylase	amylase	NOUN
dti-3271	286	8	inhibitory	inhibitory	ADJ
dti-3271	286	9	activity	activity	NOUN
dti-3271	286	10	of	of	ADP
dti-3271	286	11	senna	senna	NOUN
dti-3271	286	12	surattensis	surattensis	NOUN
dti-3271	286	13	.	.	PUNCT
dti-3271	287	1	j	j	PROPN
dti-3271	287	2	acupunct	acupunct	PROPN
dti-3271	287	3	meridian	meridian	PROPN
dti-3271	287	4	stud	stud	NOUN
dti-3271	287	5	.	.	PUNCT
dti-3271	288	1	2013;6(1):24	2013;6(1):24	NUM
dti-3271	288	2	-	-	SYM
dti-3271	288	3	30	30	NUM
dti-3271	288	4	.	.	PUNCT
dti-3271	289	1	crossref	crossref	PROPN
dti-3271	289	2	pubmed	pubmed	PROPN
dti-3271	289	3	27	27	NUM
dti-3271	289	4	.	.	PUNCT
dti-3271	290	1	de	de	PROPN
dti-3271	290	2	souza	souza	PROPN
dti-3271	290	3	pm	pm	PROPN
dti-3271	290	4	,	,	PUNCT
dti-3271	290	5	de	de	PROPN
dti-3271	290	6	oliveira	oliveira	PROPN
dti-3271	290	7	magalhães	magalhães	PROPN
dti-3271	290	8	p.	p.	PROPN
dti-3271	290	9	application	application	NOUN
dti-3271	290	10	of	of	ADP
dti-3271	290	11	microbial	microbial	ADJ
dti-3271	290	12	α	α	NOUN
dti-3271	290	13	-	-	NOUN
dti-3271	290	14	amylase	amylase	NOUN
dti-3271	290	15	in	in	ADP
dti-3271	290	16	industry	industry	NOUN
dti-3271	290	17	a	a	DET
dti-3271	290	18	review	review	NOUN
dti-3271	290	19	.	.	PUNCT
dti-3271	291	1	braz	braz	PROPN
dti-3271	291	2	j	j	PROPN
dti-3271	291	3	microbiol	microbiol	PROPN
dti-3271	291	4	.	.	PUNCT
dti-3271	292	1	2010;41(4	2010;41(4	NUM
dti-3271	292	2	)	)	PUNCT
dti-3271	292	3	,	,	PUNCT
dti-3271	292	4	850	850	NUM
dti-3271	292	5	-	-	SYM
dti-3271	292	6	861	861	NUM
dti-3271	292	7	.	.	PUNCT
dti-3271	293	1	crossref	crossref	PROPN
dti-3271	293	2	pubmed	pubmed	PROPN
dti-3271	293	3	28	28	PROPN
dti-3271	293	4	.	.	PUNCT
dti-3271	294	1	qin	qin	PROPN
dti-3271	295	1	x	x	PROPN
dti-3271	295	2	,	,	PUNCT
dti-3271	295	3	ren	ren	PROPN
dti-3271	295	4	l	l	PROPN
dti-3271	295	5	,	,	PUNCT
dti-3271	295	6	yang	yang	PROPN
dti-3271	295	7	x	x	PROPN
dti-3271	295	8	,	,	PUNCT
dti-3271	295	9	et	et	PROPN
dti-3271	295	10	al	al	PROPN
dti-3271	295	11	.	.	PROPN
dti-3271	295	12	structures	structure	NOUN
dti-3271	295	13	of	of	ADP
dti-3271	295	14	human	human	ADJ
dti-3271	295	15	pancreatic	pancreatic	ADJ
dti-3271	295	16	α	α	NOUN
dti-3271	295	17	-	-	NOUN
dti-3271	295	18	amylase	amylase	NOUN
dti-3271	295	19	in	in	ADP
dti-3271	295	20	complex	complex	NOUN
dti-3271	295	21	with	with	ADP
dti-3271	295	22	acarviostatins	acarviostatin	NOUN
dti-3271	295	23	:	:	PUNCT
dti-3271	295	24	implications	implication	NOUN
dti-3271	295	25	for	for	ADP
dti-3271	295	26	drug	drug	NOUN
dti-3271	295	27	design	design	NOUN
dti-3271	295	28	against	against	ADP
dti-3271	295	29	type	type	NOUN
dti-3271	295	30	ii	ii	NOUN
dti-3271	295	31	diabetes	diabetes	NOUN
dti-3271	295	32	.	.	PUNCT
dti-3271	296	1	j	j	PROPN
dti-3271	296	2	struct	struct	NOUN
dti-3271	296	3	biol	biol	PROPN
dti-3271	296	4	.	.	PUNCT
dti-3271	297	1	2011;174(1	2011;174(1	NUM
dti-3271	297	2	):	):	PUNCT
dti-3271	297	3	196	196	NUM
dti-3271	297	4	-	-	SYM
dti-3271	297	5	202	202	NUM
dti-3271	297	6	.	.	PUNCT
dti-3271	298	1	crossref	crossref	PROPN
dti-3271	298	2	pubmed	pubmed	PROPN
dti-3271	298	3	29	29	NUM
dti-3271	298	4	.	.	PUNCT
dti-3271	299	1	jayaraj	jayaraj	PROPN
dti-3271	299	2	s	s	PROPN
dti-3271	299	3	,	,	PUNCT
dti-3271	299	4	suresh	suresh	PROPN
dti-3271	299	5	s	s	PROPN
dti-3271	299	6	,	,	PUNCT
dti-3271	299	7	kadeppagari	kadeppagari	ADJ
dti-3271	299	8	rk	rk	NOUN
dti-3271	299	9	.	.	NOUN
dti-3271	299	10	amylase	amylase	NOUN
dti-3271	299	11	inhibitors	inhibitor	NOUN
dti-3271	299	12	and	and	CCONJ
dti-3271	299	13	their	their	PRON
dti-3271	299	14	biomedical	biomedical	ADJ
dti-3271	299	15	applications	application	NOUN
dti-3271	299	16	.	.	PUNCT
dti-3271	300	1	stärke	stärke	PROPN
dti-3271	300	2	.	.	PUNCT
dti-3271	301	1	2013;65(7	2013;65(7	NUM
dti-3271	301	2	-	-	PUNCT
dti-3271	301	3	8):535	8):535	NUM
dti-3271	301	4	-	-	PUNCT
dti-3271	301	5	542	542	NUM
dti-3271	301	6	.	.	PUNCT
dti-3271	302	1	crossref	crossref	PROPN
dti-3271	302	2	30	30	NUM
dti-3271	302	3	.	.	PUNCT
dti-3271	303	1	azam	azam	PROPN
dti-3271	303	2	ss	ss	PROPN
dti-3271	303	3	,	,	PUNCT
dti-3271	303	4	uddin	uddin	ADJ
dti-3271	303	5	r	r	NOUN
dti-3271	303	6	,	,	PUNCT
dti-3271	303	7	wadood	wadood	NOUN
dti-3271	303	8	a.	a.	NOUN
dti-3271	303	9	structure	structure	NOUN
dti-3271	303	10	and	and	CCONJ
dti-3271	303	11	dynamics	dynamic	NOUN
dti-3271	303	12	of	of	ADP
dti-3271	303	13	alphaglucosidase	alphaglucosidase	PROPN
dti-3271	303	14	through	through	ADP
dti-3271	303	15	molecular	molecular	ADJ
dti-3271	303	16	dynamics	dynamic	NOUN
dti-3271	303	17	simulation	simulation	NOUN
dti-3271	303	18	studies	study	NOUN
dti-3271	303	19	.	.	PUNCT
dti-3271	304	1	j	j	PROPN
dti-3271	304	2	mol	mol	ADP
dti-3271	304	3	liq	liq	PROPN
dti-3271	304	4	.	.	PUNCT
dti-3271	305	1	2012;174:58	2012;174:58	NUM
dti-3271	305	2	-	-	SYM
dti-3271	305	3	62	62	NUM
dti-3271	305	4	.	.	PUNCT
dti-3271	306	1	crossref	crossref	PROPN
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dti-3271	306	3	https://pubmed.ncbi.nlm.nih.gov/31242688	https://pubmed.ncbi.nlm.nih.gov/31242688	PROPN
dti-3271	306	4	https://doi.org/10.1155/2023/5553913	https://doi.org/10.1155/2023/5553913	PROPN
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dti-3271	306	6	https://pubmed.ncbi.nlm.nih.gov/35658208	https://pubmed.ncbi.nlm.nih.gov/35658208	PRON
dti-3271	306	7	https://doi.org/10.1016/j.bmcl.2015.05.069	https://doi.org/10.1016/j.bmcl.2015.05.069	PROPN
dti-3271	306	8	https://pubmed.ncbi.nlm.nih.gov/26077497	https://pubmed.ncbi.nlm.nih.gov/26077497	NOUN
dti-3271	306	9	https://doi.org/10.3390/ph16030344	https://doi.org/10.3390/ph16030344	NOUN
dti-3271	306	10	https://doi.org/10.1042/bj3460201	https://doi.org/10.1042/bj3460201	X
dti-3271	306	11	https://pubmed.ncbi.nlm.nih.gov/10657258	https://pubmed.ncbi.nlm.nih.gov/10657258	PROPN
dti-3271	306	12	https://doi.org/10.1111/j.1742-4658.2010.07810.x	https://doi.org/10.1111/j.1742-4658.2010.07810.x	PROPN
dti-3271	306	13	https://pubmed.ncbi.nlm.nih.gov/20812985	https://pubmed.ncbi.nlm.nih.gov/20812985	PRON
dti-3271	306	14	https://doi.org/10.1038/nchembio.1199	https://doi.org/10.1038/nchembio.1199	VERB
dti-3271	306	15	https://pubmed.ncbi.nlm.nih.gov/23508189	https://pubmed.ncbi.nlm.nih.gov/23508189	PRON
dti-3271	306	16	https://pubmed.ncbi.nlm.nih.gov/22457553	https://pubmed.ncbi.nlm.nih.gov/22457553	PROPN
dti-3271	306	17	https://doi.org/10.1016/j.metabol.2006.02.011	https://doi.org/10.1016/j.metabol.2006.02.011	PROPN
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dti-3271	306	19	https://doi.org/10.5114/aoms.2012.31621	https://doi.org/10.5114/aoms.2012.31621	PROPN
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dti-3271	306	21	https://doi.org/10.1016/j.jams.2012.10.005	https://doi.org/10.1016/j.jams.2012.10.005	PROPN
dti-3271	307	1	https://pubmed.ncbi.nlm.nih.gov/23433052	https://pubmed.ncbi.nlm.nih.gov/23433052	INTJ
dti-3271	307	2	https://doi.org/10.1590/s1517-83822010000400004	https://doi.org/10.1590/s1517-83822010000400004	PROPN
dti-3271	307	3	https://pubmed.ncbi.nlm.nih.gov/24031565	https://pubmed.ncbi.nlm.nih.gov/24031565	ADV
dti-3271	307	4	https://doi.org/10.1016/j.jsb.2010.11.020	https://doi.org/10.1016/j.jsb.2010.11.020	VERB
dti-3271	307	5	https://pubmed.ncbi.nlm.nih.gov/21111049	https://pubmed.ncbi.nlm.nih.gov/21111049	PROPN
dti-3271	307	6	https://doi.org/10.1002/star.201200194	https://doi.org/10.1002/star.201200194	PROPN
dti-3271	307	7	https://doi.org/10.1016/j.molliq.2012.07.003	https://doi.org/10.1016/j.molliq.2012.07.003	PROPN