id	sid	tid	token	lemma	pos
dti-3495	1	1	dti	dti	PROPN
dti-3495	1	2	drug	drug	PROPN
dti-3495	1	3	target	target	NOUN
dti-3495	1	4	insights	insight	NOUN
dti-3495	1	5	2025	2025	NUM
dti-3495	1	6	;	;	PUNCT
dti-3495	1	7	19	19	NUM
dti-3495	1	8	:	:	SYM
dti-3495	1	9	71	71	NUM
dti-3495	1	10	-	-	SYM
dti-3495	1	11	90	90	NUM
dti-3495	1	12	issn	issn	PROPN
dti-3495	1	13	1177	1177	NUM
dti-3495	1	14	-	-	SYM
dti-3495	1	15	3928	3928	NUM
dti-3495	1	16	|	|	ADV
dti-3495	1	17	doi	doi	NOUN
dti-3495	1	18	:	:	PUNCT
dti-3495	1	19	10.33393	10.33393	NUM
dti-3495	1	20	/	/	SYM
dti-3495	1	21	dti.2025.3495	dti.2025.3495	ADJ
dti-3495	1	22	original	original	ADJ
dti-3495	1	23	research	research	NOUN
dti-3495	1	24	article	article	NOUN
dti-3495	1	25	drug	drug	NOUN
dti-3495	1	26	target	target	NOUN
dti-3495	1	27	insights	insight	NOUN
dti-3495	1	28	issn	issn	VERB
dti-3495	1	29	1177	1177	NUM
dti-3495	1	30	-	-	SYM
dti-3495	1	31	3928	3928	NUM
dti-3495	1	32	www.aboutscience.eu/dti	www.aboutscience.eu/dti	NOUN
dti-3495	1	33	©	©	PROPN
dti-3495	1	34	2025	2025	NUM
dti-3495	1	35	the	the	DET
dti-3495	1	36	authors	author	NOUN
dti-3495	1	37	.	.	PUNCT
dti-3495	2	1	this	this	DET
dti-3495	2	2	article	article	NOUN
dti-3495	2	3	is	be	AUX
dti-3495	2	4	published	publish	VERB
dti-3495	2	5	by	by	ADP
dti-3495	2	6	aboutscience	aboutscience	NOUN
dti-3495	2	7	and	and	CCONJ
dti-3495	2	8	licensed	license	VERB
dti-3495	2	9	under	under	ADP
dti-3495	2	10	creative	creative	ADJ
dti-3495	2	11	commons	common	NOUN
dti-3495	2	12	attribution	attribution	NOUN
dti-3495	2	13	-	-	PUNCT
dti-3495	2	14	noncommercial	noncommercial	ADJ
dti-3495	2	15	4.0	4.0	NUM
dti-3495	2	16	international	international	NOUN
dti-3495	2	17	(	(	PUNCT
dti-3495	2	18	cc	cc	NOUN
dti-3495	2	19	by	by	ADP
dti-3495	2	20	-	-	PUNCT
dti-3495	2	21	nc	nc	PROPN
dti-3495	2	22	4.0	4.0	NUM
dti-3495	2	23	)	)	PUNCT
dti-3495	2	24	.	.	PUNCT
dti-3495	3	1	commercial	commercial	ADJ
dti-3495	3	2	use	use	NOUN
dti-3495	3	3	is	be	AUX
dti-3495	3	4	not	not	PART
dti-3495	3	5	permitted	permit	VERB
dti-3495	3	6	and	and	CCONJ
dti-3495	3	7	is	be	AUX
dti-3495	3	8	subject	subject	ADJ
dti-3495	3	9	to	to	ADP
dti-3495	3	10	publisher	publisher	NOUN
dti-3495	3	11	’s	’s	PART
dti-3495	3	12	permissions	permission	NOUN
dti-3495	3	13	.	.	PUNCT
dti-3495	4	1	full	full	ADJ
dti-3495	4	2	information	information	NOUN
dti-3495	4	3	is	be	AUX
dti-3495	4	4	available	available	ADJ
dti-3495	4	5	at	at	ADP
dti-3495	4	6	www.aboutscience.eu	www.aboutscience.eu	NOUN
dti-3495	4	7	integrated	integrate	VERB
dti-3495	4	8	in	in	ADP
dti-3495	4	9	vitro	vitro	X
dti-3495	4	10	,	,	PUNCT
dti-3495	4	11	microarray	microarray	NOUN
dti-3495	4	12	,	,	PUNCT
dti-3495	4	13	and	and	CCONJ
dti-3495	4	14	network	network	NOUN
dti-3495	4	15	pharmacology	pharmacology	NOUN
dti-3495	4	16	analysis	analysis	NOUN
dti-3495	4	17	reveals	reveal	VERB
dti-3495	4	18	the	the	DET
dti-3495	4	19	multi	multi	ADJ
dti-3495	4	20	-	-	ADJ
dti-3495	4	21	target	target	ADJ
dti-3495	4	22	anti	anti	ADJ
dti-3495	4	23	-	-	ADJ
dti-3495	4	24	diabetic	diabetic	ADJ
dti-3495	4	25	potential	potential	NOUN
dti-3495	4	26	of	of	ADP
dti-3495	4	27	vigna	vigna	PROPN
dti-3495	4	28	unguiculata	unguiculata	PROPN
dti-3495	4	29	haseeba	haseeba	PROPN
dti-3495	4	30	sardar1	sardar1	PROPN
dti-3495	4	31	,	,	PUNCT
dti-3495	4	32	fatima	fatima	PROPN
dti-3495	4	33	noor2	noor2	PROPN
dti-3495	4	34	,	,	PUNCT
dti-3495	4	35	syed	syed	PROPN
dti-3495	4	36	muhammad	muhammad	PROPN
dti-3495	4	37	mukarram	mukarram	PROPN
dti-3495	4	38	shah	shah	PROPN
dti-3495	4	39	3	3	NUM
dti-3495	4	40	,	,	PUNCT
dti-3495	4	41	ashraf	ashraf	VERB
dti-3495	4	42	ullah	ullah	PROPN
dti-3495	4	43	khan	khan	PROPN
dti-3495	4	44	4	4	NUM
dti-3495	4	45	,	,	PUNCT
dti-3495	4	46	jamelah	jamelah	PROPN
dti-3495	4	47	s	s	PROPN
dti-3495	4	48	al	al	PROPN
dti-3495	4	49	-	-	PUNCT
dti-3495	4	50	otaibi5	otaibi5	PROPN
dti-3495	4	51	,	,	PUNCT
dti-3495	4	52	fazal	fazal	PROPN
dti-3495	4	53	hadi	hadi	PROPN
dti-3495	4	54	1	1	NUM
dti-3495	4	55	,	,	PUNCT
dti-3495	4	56	maria	maria	PROPN
dti-3495	4	57	daglia	daglia	PROPN
dti-3495	4	58	6,7	6,7	NUM
dti-3495	4	59	,	,	PUNCT
dti-3495	4	60	haroon	haroon	PROPN
dti-3495	4	61	khan1,8	khan1,8	PROPN
dti-3495	4	62	1department	1department	NUM
dti-3495	4	63	of	of	ADP
dti-3495	4	64	pharmacy	pharmacy	NOUN
dti-3495	4	65	,	,	PUNCT
dti-3495	4	66	abdul	abdul	PROPN
dti-3495	4	67	wali	wali	PROPN
dti-3495	4	68	khan	khan	PROPN
dti-3495	4	69	university	university	PROPN
dti-3495	4	70	,	,	PUNCT
dti-3495	4	71	mardan	mardan	PROPN
dti-3495	4	72	pakistan	pakistan	PROPN
dti-3495	4	73	2institute	2institute	NUM
dti-3495	4	74	of	of	ADP
dti-3495	4	75	molecular	molecular	ADJ
dti-3495	4	76	biology	biology	NOUN
dti-3495	4	77	and	and	CCONJ
dti-3495	4	78	biotechnology	biotechnology	NOUN
dti-3495	4	79	,	,	PUNCT
dti-3495	4	80	the	the	DET
dti-3495	4	81	university	university	NOUN
dti-3495	4	82	of	of	ADP
dti-3495	4	83	lahore	lahore	NOUN
dti-3495	4	84	,	,	PUNCT
dti-3495	4	85	lahore	lahore	PROPN
dti-3495	4	86	pakistan	pakistan	PROPN
dti-3495	4	87	3department	3department	NUM
dti-3495	4	88	of	of	ADP
dti-3495	4	89	pharmacy	pharmacy	NOUN
dti-3495	4	90	,	,	PUNCT
dti-3495	4	91	university	university	NOUN
dti-3495	4	92	of	of	ADP
dti-3495	4	93	swabi	swabi	PROPN
dti-3495	4	94	,	,	PUNCT
dti-3495	4	95	swabi	swabi	NOUN
dti-3495	4	96	pakistan	pakistan	PROPN
dti-3495	4	97	4faculty	4faculty	NUM
dti-3495	4	98	of	of	ADP
dti-3495	4	99	pharmaceutical	pharmaceutical	NOUN
dti-3495	4	100	sciences	science	NOUN
dti-3495	4	101	,	,	PUNCT
dti-3495	4	102	abasyn	abasyn	NOUN
dti-3495	4	103	university	university	NOUN
dti-3495	4	104	,	,	PUNCT
dti-3495	4	105	peshawar	peshawar	NOUN
dti-3495	4	106	pakistan	pakistan	PROPN
dti-3495	5	1	5department	5department	NUM
dti-3495	5	2	of	of	ADP
dti-3495	5	3	chemistry	chemistry	NOUN
dti-3495	5	4	,	,	PUNCT
dti-3495	5	5	college	college	NOUN
dti-3495	5	6	of	of	ADP
dti-3495	5	7	science	science	NOUN
dti-3495	5	8	,	,	PUNCT
dti-3495	5	9	princess	princess	PROPN
dti-3495	5	10	nourah	nourah	PROPN
dti-3495	5	11	bint	bint	PROPN
dti-3495	5	12	abdulrahman	abdulrahman	PROPN
dti-3495	5	13	university	university	PROPN
dti-3495	5	14	,	,	PUNCT
dti-3495	5	15	riyadh	riyadh	PROPN
dti-3495	5	16	saudi	saudi	PROPN
dti-3495	5	17	arabia	arabia	PROPN
dti-3495	5	18	6department	6department	NUM
dti-3495	5	19	of	of	ADP
dti-3495	5	20	pharmacy	pharmacy	NOUN
dti-3495	5	21	,	,	PUNCT
dti-3495	5	22	university	university	PROPN
dti-3495	5	23	of	of	ADP
dti-3495	5	24	naples	naples	PROPN
dti-3495	5	25	federico	federico	PROPN
dti-3495	5	26	ii	ii	PROPN
dti-3495	5	27	,	,	PUNCT
dti-3495	5	28	naples	naples	PROPN
dti-3495	5	29	italy	italy	PROPN
dti-3495	6	1	7international	7international	NUM
dti-3495	6	2	research	research	NOUN
dti-3495	6	3	center	center	NOUN
dti-3495	6	4	for	for	ADP
dti-3495	6	5	food	food	NOUN
dti-3495	6	6	nutrition	nutrition	NOUN
dti-3495	6	7	and	and	CCONJ
dti-3495	6	8	safety	safety	NOUN
dti-3495	6	9	,	,	PUNCT
dti-3495	6	10	jiangsu	jiangsu	PROPN
dti-3495	6	11	university	university	PROPN
dti-3495	6	12	,	,	PUNCT
dti-3495	6	13	zhenjiang	zhenjiang	PROPN
dti-3495	6	14	china	china	PROPN
dti-3495	6	15	8department	8department	NUM
dti-3495	6	16	of	of	ADP
dti-3495	6	17	pharmacy	pharmacy	PROPN
dti-3495	6	18	,	,	PUNCT
dti-3495	6	19	korea	korea	PROPN
dti-3495	6	20	university	university	PROPN
dti-3495	6	21	,	,	PUNCT
dti-3495	6	22	sejong	sejong	PROPN
dti-3495	6	23	south	south	PROPN
dti-3495	6	24	korea	korea	PROPN
dti-3495	6	25	abstract	abstract	ADJ
dti-3495	6	26	introduction	introduction	NOUN
dti-3495	6	27	:	:	PUNCT
dti-3495	6	28	diabetes	diabetes	NOUN
dti-3495	6	29	mellitus	mellitus	NOUN
dti-3495	6	30	(	(	PUNCT
dti-3495	6	31	dm	dm	PROPN
dti-3495	6	32	)	)	PUNCT
dti-3495	6	33	,	,	PUNCT
dti-3495	6	34	particularly	particularly	ADV
dti-3495	6	35	type	type	NOUN
dti-3495	6	36	2	2	NUM
dti-3495	6	37	dm	dm	PROPN
dti-3495	6	38	(	(	PUNCT
dti-3495	6	39	t2	t2	PROPN
dti-3495	6	40	dm	dm	PROPN
dti-3495	6	41	)	)	PUNCT
dti-3495	6	42	,	,	PUNCT
dti-3495	6	43	is	be	AUX
dti-3495	6	44	a	a	DET
dti-3495	6	45	chronic	chronic	ADJ
dti-3495	6	46	metabolic	metabolic	NOUN
dti-3495	6	47	disorder	disorder	NOUN
dti-3495	6	48	requiring	require	VERB
dti-3495	6	49	novel	novel	ADJ
dti-3495	6	50	therapeutic	therapeutic	ADJ
dti-3495	6	51	approaches	approach	NOUN
dti-3495	6	52	as	as	ADP
dti-3495	6	53	the	the	DET
dti-3495	6	54	available	available	ADJ
dti-3495	6	55	therapies	therapy	NOUN
dti-3495	6	56	are	be	AUX
dti-3495	6	57	not	not	PART
dti-3495	6	58	meeting	meet	VERB
dti-3495	6	59	the	the	DET
dti-3495	6	60	current	current	ADJ
dti-3495	6	61	challenges	challenge	NOUN
dti-3495	6	62	.	.	PUNCT
dti-3495	7	1	this	this	DET
dti-3495	7	2	study	study	NOUN
dti-3495	7	3	investigates	investigate	VERB
dti-3495	7	4	the	the	DET
dti-3495	7	5	anti	anti	ADJ
dti-3495	7	6	-	-	ADJ
dti-3495	7	7	diabetic	diabetic	ADJ
dti-3495	7	8	potential	potential	NOUN
dti-3495	7	9	of	of	ADP
dti-3495	7	10	vigna	vigna	PROPN
dti-3495	7	11	unguiculata	unguiculata	PROPN
dti-3495	7	12	using	use	VERB
dti-3495	7	13	a	a	DET
dti-3495	7	14	network	network	NOUN
dti-3495	7	15	pharmacology	pharmacology	NOUN
dti-3495	7	16	approach	approach	NOUN
dti-3495	7	17	,	,	PUNCT
dti-3495	7	18	supported	support	VERB
dti-3495	7	19	by	by	ADP
dti-3495	7	20	in	in	ADP
dti-3495	7	21	vitro	vitro	X
dti-3495	7	22	and	and	CCONJ
dti-3495	7	23	in	in	ADP
dti-3495	7	24	silico	silico	NOUN
dti-3495	7	25	analyses	analysis	NOUN
dti-3495	7	26	.	.	PUNCT
dti-3495	8	1	methods	method	NOUN
dti-3495	8	2	:	:	PUNCT
dti-3495	8	3	the	the	DET
dti-3495	8	4	plant	plant	NOUN
dti-3495	8	5	was	be	AUX
dti-3495	8	6	collected	collect	VERB
dti-3495	8	7	from	from	ADP
dti-3495	8	8	khyber	khyber	PROPN
dti-3495	8	9	pakhtunkhwa	pakhtunkhwa	PROPN
dti-3495	8	10	,	,	PUNCT
dti-3495	8	11	pakistan	pakistan	PROPN
dti-3495	8	12	,	,	PUNCT
dti-3495	8	13	and	and	CCONJ
dti-3495	8	14	subjected	subject	VERB
dti-3495	8	15	to	to	ADP
dti-3495	8	16	hydroalcoholic	hydroalcoholic	ADJ
dti-3495	8	17	extraction	extraction	NOUN
dti-3495	8	18	and	and	CCONJ
dti-3495	8	19	fractionation	fractionation	NOUN
dti-3495	8	20	.	.	PUNCT
dti-3495	9	1	in	in	ADP
dti-3495	9	2	vitro	vitro	X
dti-3495	9	3	assays	assay	NOUN
dti-3495	9	4	included	include	VERB
dti-3495	9	5	α	α	DET
dti-3495	9	6	-	-	NOUN
dti-3495	9	7	amylase	amylase	NOUN
dti-3495	9	8	,	,	PUNCT
dti-3495	9	9	α	α	NOUN
dti-3495	9	10	-	-	NOUN
dti-3495	9	11	glucosidase	glucosidase	NOUN
dti-3495	9	12	,	,	PUNCT
dti-3495	9	13	and	and	CCONJ
dti-3495	9	14	aldose	aldose	PRON
dti-3495	9	15	reductase	reductase	NOUN
dti-3495	9	16	.	.	PUNCT
dti-3495	10	1	target	target	NOUN
dti-3495	10	2	prediction	prediction	NOUN
dti-3495	10	3	using	use	VERB
dti-3495	10	4	stitch	stitch	NOUN
dti-3495	10	5	and	and	CCONJ
dti-3495	10	6	swisstargetprediction	swisstargetprediction	NOUN
dti-3495	10	7	identified	identify	VERB
dti-3495	10	8	88	88	NUM
dti-3495	10	9	common	common	ADJ
dti-3495	10	10	genes	gene	NOUN
dti-3495	10	11	linked	link	VERB
dti-3495	10	12	to	to	ADP
dti-3495	10	13	t2	t2	PROPN
dti-3495	10	14	dm	dm	PROPN
dti-3495	10	15	.	.	PUNCT
dti-3495	10	16	protein	protein	NOUN
dti-3495	10	17	-	-	PUNCT
dti-3495	10	18	protein	protein	NOUN
dti-3495	10	19	interaction	interaction	NOUN
dti-3495	10	20	(	(	PUNCT
dti-3495	10	21	ppi	ppi	NOUN
dti-3495	10	22	)	)	PUNCT
dti-3495	10	23	network	network	NOUN
dti-3495	10	24	analysis	analysis	NOUN
dti-3495	10	25	highlighted	highlight	VERB
dti-3495	10	26	key	key	ADJ
dti-3495	10	27	genes	gene	NOUN
dti-3495	10	28	like	like	ADP
dti-3495	10	29	egfr	egfr	NOUN
dti-3495	10	30	,	,	PUNCT
dti-3495	10	31	ptgs2	ptgs2	PROPN
dti-3495	10	32	,	,	PUNCT
dti-3495	10	33	and	and	CCONJ
dti-3495	10	34	tlr4	tlr4	NOUN
dti-3495	10	35	as	as	ADP
dti-3495	10	36	central	central	ADJ
dti-3495	10	37	nodes	node	NOUN
dti-3495	10	38	in	in	ADP
dti-3495	10	39	diabetes	diabetes	NOUN
dti-3495	10	40	-	-	PUNCT
dti-3495	10	41	related	relate	VERB
dti-3495	10	42	pathways	pathway	NOUN
dti-3495	10	43	.	.	PUNCT
dti-3495	11	1	molecular	molecular	ADJ
dti-3495	11	2	docking	docking	NOUN
dti-3495	11	3	was	be	AUX
dti-3495	11	4	used	use	VERB
dti-3495	11	5	to	to	PART
dti-3495	11	6	study	study	VERB
dti-3495	11	7	the	the	DET
dti-3495	11	8	binding	bind	VERB
dti-3495	11	9	affinities	affinity	NOUN
dti-3495	11	10	of	of	ADP
dti-3495	11	11	compounds	compound	NOUN
dti-3495	11	12	.	.	PUNCT
dti-3495	12	1	results	result	NOUN
dti-3495	12	2	:	:	PUNCT
dti-3495	12	3	ic50	ic50	PROPN
dti-3495	12	4	values	value	NOUN
dti-3495	12	5	were	be	AUX
dti-3495	12	6	determined	determine	VERB
dti-3495	12	7	using	use	VERB
dti-3495	12	8	ibm	ibm	PROPN
dti-3495	12	9	spss	spss	PROPN
dti-3495	12	10	statistics	statistic	NOUN
dti-3495	12	11	21	21	NUM
dti-3495	12	12	software	software	NOUN
dti-3495	12	13	.	.	PUNCT
dti-3495	13	1	the	the	DET
dti-3495	13	2	data	datum	NOUN
dti-3495	13	3	underwent	undergo	VERB
dti-3495	13	4	analysis	analysis	NOUN
dti-3495	13	5	using	use	VERB
dti-3495	13	6	one	one	NUM
dti-3495	13	7	-	-	PUNCT
dti-3495	13	8	way	way	NOUN
dti-3495	13	9	anova	anova	PROPN
dti-3495	13	10	followed	follow	VERB
dti-3495	13	11	by	by	ADP
dti-3495	13	12	dunnett	dunnett	PROPN
dti-3495	13	13	’s	’s	PART
dti-3495	13	14	multiple	multiple	ADJ
dti-3495	13	15	comparison	comparison	NOUN
dti-3495	13	16	test	test	NOUN
dti-3495	13	17	.	.	PUNCT
dti-3495	14	1	significance	significance	NOUN
dti-3495	14	2	value	value	NOUN
dti-3495	14	3	was	be	AUX
dti-3495	14	4	determined	determine	VERB
dti-3495	14	5	at	at	ADP
dti-3495	14	6	*	*	PUNCT
dti-3495	14	7	p	p	X
dti-3495	14	8	<	<	X
dti-3495	14	9	0.05	0.05	NUM
dti-3495	14	10	,	,	PUNCT
dti-3495	14	11	*	*	PUNCT
dti-3495	14	12	*	*	PUNCT
dti-3495	14	13	p	p	X
dti-3495	14	14	<	<	X
dti-3495	14	15	0.01	0.01	NUM
dti-3495	14	16	and	and	CCONJ
dti-3495	14	17	*	*	NOUN
dti-3495	14	18	*	*	PUNCT
dti-3495	14	19	*	*	PUNCT
dti-3495	14	20	p	p	X
dti-3495	14	21	<	<	X
dti-3495	14	22	0.001	0.001	NUM
dti-3495	14	23	.	.	PUNCT
dti-3495	15	1	in	in	ADP
dti-3495	15	2	-	-	PUNCT
dti-3495	15	3	vitro	vitro	X
dti-3495	15	4	assays	assay	NOUN
dti-3495	15	5	demonstrated	demonstrate	VERB
dti-3495	15	6	significant	significant	ADJ
dti-3495	15	7	α	α	NOUN
dti-3495	15	8	-	-	NOUN
dti-3495	15	9	amylase	amylase	NOUN
dti-3495	15	10	,	,	PUNCT
dti-3495	15	11	α	α	NOUN
dti-3495	15	12	-	-	NOUN
dti-3495	15	13	glucosidase	glucosidase	NOUN
dti-3495	15	14	,	,	PUNCT
dti-3495	15	15	and	and	CCONJ
dti-3495	15	16	aldose	aldose	PRON
dti-3495	15	17	reductase	reductase	NOUN
dti-3495	15	18	inhibitory	inhibitory	ADJ
dti-3495	15	19	activities	activity	NOUN
dti-3495	15	20	.	.	PUNCT
dti-3495	16	1	phytochemical	phytochemical	ADJ
dti-3495	16	2	screening	screening	NOUN
dti-3495	16	3	identified	identify	VERB
dti-3495	16	4	several	several	ADJ
dti-3495	16	5	bioactive	bioactive	ADJ
dti-3495	16	6	compounds	compound	NOUN
dti-3495	16	7	.	.	PUNCT
dti-3495	17	1	functional	functional	ADJ
dti-3495	17	2	annotation	annotation	NOUN
dti-3495	17	3	and	and	CCONJ
dti-3495	17	4	kegg	kegg	NOUN
dti-3495	17	5	pathway	pathway	NOUN
dti-3495	17	6	analysis	analysis	NOUN
dti-3495	17	7	confirmed	confirm	VERB
dti-3495	17	8	these	these	DET
dti-3495	17	9	genes	gene	NOUN
dti-3495	17	10	’	'	PUNCT
dti-3495	17	11	roles	role	NOUN
dti-3495	17	12	in	in	ADP
dti-3495	17	13	crucial	crucial	ADJ
dti-3495	17	14	metabolic	metabolic	NOUN
dti-3495	17	15	pathways	pathway	NOUN
dti-3495	17	16	.	.	PUNCT
dti-3495	18	1	virtual	virtual	ADJ
dti-3495	18	2	screening	screening	NOUN
dti-3495	18	3	revealed	reveal	VERB
dti-3495	18	4	strong	strong	ADJ
dti-3495	18	5	binding	bind	VERB
dti-3495	18	6	affinities	affinity	NOUN
dti-3495	18	7	of	of	ADP
dti-3495	18	8	compounds	compound	NOUN
dti-3495	18	9	like	like	ADP
dti-3495	18	10	stigmasterol	stigmasterol	NOUN
dti-3495	18	11	,	,	PUNCT
dti-3495	18	12	luteoline	luteoline	NOUN
dti-3495	18	13	,	,	PUNCT
dti-3495	18	14	and	and	CCONJ
dti-3495	18	15	quercetin	quercetin	NOUN
dti-3495	18	16	with	with	ADP
dti-3495	18	17	gsk3b	gsk3b	PROPN
dti-3495	18	18	,	,	PUNCT
dti-3495	18	19	ptgs2	ptgs2	PROPN
dti-3495	18	20	,	,	PUNCT
dti-3495	18	21	and	and	CCONJ
dti-3495	18	22	tlr4	tlr4	NOUN
dti-3495	18	23	.	.	PUNCT
dti-3495	19	1	the	the	DET
dti-3495	19	2	molecular	molecular	ADJ
dti-3495	19	3	dynamics	dynamic	NOUN
dti-3495	19	4	(	(	PUNCT
dti-3495	19	5	md	md	PROPN
dti-3495	19	6	)	)	PUNCT
dti-3495	19	7	simulation	simulation	NOUN
dti-3495	19	8	,	,	PUNCT
dti-3495	19	9	binding	bind	VERB
dti-3495	19	10	free	free	ADJ
dti-3495	19	11	energy	energy	NOUN
dti-3495	19	12	calculations	calculation	NOUN
dti-3495	19	13	(	(	PUNCT
dti-3495	19	14	mm	mm	NOUN
dti-3495	19	15	-	-	PUNCT
dti-3495	19	16	pbsa	pbsa	NOUN
dti-3495	19	17	and	and	CCONJ
dti-3495	19	18	mm	mm	NOUN
dti-3495	19	19	-	-	PUNCT
dti-3495	19	20	gbsa	gbsa	NOUN
dti-3495	19	21	)	)	PUNCT
dti-3495	19	22	,	,	PUNCT
dti-3495	19	23	confirmed	confirm	VERB
dti-3495	19	24	the	the	DET
dti-3495	19	25	results	result	NOUN
dti-3495	19	26	of	of	ADP
dti-3495	19	27	virtual	virtual	ADJ
dti-3495	19	28	screening	screening	NOUN
dti-3495	19	29	.	.	PUNCT
dti-3495	20	1	conclusion	conclusion	NOUN
dti-3495	20	2	:	:	PUNCT
dti-3495	20	3	in	in	ADP
dti-3495	20	4	short	short	ADJ
dti-3495	20	5	,	,	PUNCT
dti-3495	20	6	these	these	DET
dti-3495	20	7	findings	finding	NOUN
dti-3495	20	8	underscore	underscore	VERB
dti-3495	20	9	v.	v.	ADP
dti-3495	20	10	unguiculata	unguiculata	ADJ
dti-3495	20	11	as	as	ADP
dti-3495	20	12	a	a	DET
dti-3495	20	13	promising	promising	ADJ
dti-3495	20	14	source	source	NOUN
dti-3495	20	15	for	for	ADP
dti-3495	20	16	anti	anti	ADJ
dti-3495	20	17	-	-	ADJ
dti-3495	20	18	diabetic	diabetic	ADJ
dti-3495	20	19	agents	agent	NOUN
dti-3495	20	20	,	,	PUNCT
dti-3495	20	21	supporting	support	VERB
dti-3495	20	22	further	further	ADJ
dti-3495	20	23	clinical	clinical	ADJ
dti-3495	20	24	trials	trial	NOUN
dti-3495	20	25	for	for	ADP
dti-3495	20	26	t2	t2	NOUN
dti-3495	20	27	dm	dm	PROPN
dti-3495	20	28	management	management	NOUN
dti-3495	20	29	.	.	PUNCT
dti-3495	21	1	keywords	keyword	NOUN
dti-3495	21	2	:	:	PUNCT
dti-3495	21	3	diabetes	diabete	NOUN
dti-3495	21	4	,	,	PUNCT
dti-3495	21	5	in	in	ADP
dti-3495	21	6	vitro	vitro	X
dti-3495	21	7	,	,	PUNCT
dti-3495	21	8	molecular	molecular	ADJ
dti-3495	21	9	docking	docking	NOUN
dti-3495	21	10	,	,	PUNCT
dti-3495	21	11	md	md	PROPN
dti-3495	21	12	simulation	simulation	PROPN
dti-3495	21	13	,	,	PUNCT
dti-3495	21	14	network	network	NOUN
dti-3495	21	15	pharmacology	pharmacology	NOUN
dti-3495	21	16	,	,	PUNCT
dti-3495	21	17	protein	protein	NOUN
dti-3495	21	18	-	-	PUNCT
dti-3495	21	19	protein	protein	NOUN
dti-3495	21	20	interaction	interaction	NOUN
dti-3495	21	21	(	(	PUNCT
dti-3495	21	22	ppi	ppi	NOUN
dti-3495	21	23	)	)	PUNCT
dti-3495	21	24	network	network	NOUN
dti-3495	21	25	,	,	PUNCT
dti-3495	21	26	vigna	vigna	PROPN
dti-3495	21	27	unguiculata	unguiculata	VERB
dti-3495	21	28	eventual	eventual	ADJ
dti-3495	21	29	malfunction	malfunction	NOUN
dti-3495	21	30	of	of	ADP
dti-3495	21	31	pancreatic	pancreatic	ADJ
dti-3495	21	32	beta	beta	NOUN
dti-3495	21	33	-	-	PUNCT
dti-3495	21	34	cells	cell	NOUN
dti-3495	21	35	(	(	PUNCT
dti-3495	21	36	1	1	NUM
dti-3495	21	37	)	)	PUNCT
dti-3495	21	38	.	.	PUNCT
dti-3495	22	1	the	the	DET
dti-3495	22	2	impact	impact	NOUN
dti-3495	22	3	of	of	ADP
dti-3495	22	4	this	this	DET
dti-3495	22	5	prevalent	prevalent	ADJ
dti-3495	22	6	form	form	NOUN
dti-3495	22	7	of	of	ADP
dti-3495	22	8	diabetes	diabetes	NOUN
dti-3495	22	9	is	be	AUX
dti-3495	22	10	significant	significant	ADJ
dti-3495	22	11	worldwide	worldwide	ADV
dti-3495	22	12	,	,	PUNCT
dti-3495	22	13	accounting	account	VERB
dti-3495	22	14	for	for	ADP
dti-3495	22	15	around	around	ADV
dti-3495	22	16	90	90	NUM
dti-3495	22	17	%	%	NOUN
dti-3495	22	18	of	of	ADP
dti-3495	22	19	cases	case	NOUN
dti-3495	22	20	.	.	PUNCT
dti-3495	23	1	this	this	DET
dti-3495	23	2	impact	impact	NOUN
dti-3495	23	3	is	be	AUX
dti-3495	23	4	felt	feel	VERB
dti-3495	23	5	deeply	deeply	ADV
dti-3495	23	6	in	in	ADP
dti-3495	23	7	terms	term	NOUN
dti-3495	23	8	of	of	ADP
dti-3495	23	9	both	both	CCONJ
dti-3495	23	10	individual	individual	ADJ
dti-3495	23	11	health	health	NOUN
dti-3495	23	12	and	and	CCONJ
dti-3495	23	13	healthcare	healthcare	PROPN
dti-3495	23	14	systems	system	NOUN
dti-3495	23	15	(	(	PUNCT
dti-3495	23	16	2,3	2,3	NUM
dti-3495	23	17	)	)	PUNCT
dti-3495	23	18	.	.	PUNCT
dti-3495	24	1	t2	t2	PROPN
dti-3495	24	2	dm	dm	PROPN
dti-3495	24	3	’s	’s	PART
dti-3495	24	4	worldwide	worldwide	ADJ
dti-3495	24	5	occurrence	occurrence	NOUN
dti-3495	24	6	is	be	AUX
dti-3495	24	7	on	on	ADP
dti-3495	24	8	the	the	DET
dti-3495	24	9	rise	rise	NOUN
dti-3495	24	10	due	due	ADP
dti-3495	24	11	to	to	ADP
dti-3495	24	12	factors	factor	NOUN
dti-3495	24	13	like	like	ADP
dti-3495	24	14	longer	long	ADJ
dti-3495	24	15	life	life	NOUN
dti-3495	24	16	expectancy	expectancy	NOUN
dti-3495	24	17	,	,	PUNCT
dti-3495	24	18	lack	lack	NOUN
dti-3495	24	19	of	of	ADP
dti-3495	24	20	physical	physical	ADJ
dti-3495	24	21	activity	activity	NOUN
dti-3495	24	22	,	,	PUNCT
dti-3495	24	23	and	and	CCONJ
dti-3495	24	24	shifts	shift	NOUN
dti-3495	24	25	in	in	ADP
dti-3495	24	26	eating	eat	VERB
dti-3495	24	27	habits	habit	NOUN
dti-3495	24	28	,	,	PUNCT
dti-3495	24	29	which	which	PRON
dti-3495	24	30	makes	make	VERB
dti-3495	24	31	it	it	PRON
dti-3495	24	32	a	a	DET
dti-3495	24	33	significant	significant	ADJ
dti-3495	24	34	issue	issue	NOUN
dti-3495	24	35	in	in	ADP
dti-3495	24	36	the	the	DET
dti-3495	24	37	epidemiology	epidemiology	NOUN
dti-3495	24	38	of	of	ADP
dti-3495	24	39	non	non	ADJ
dti-3495	24	40	-	-	ADJ
dti-3495	24	41	communicable	communicable	ADJ
dti-3495	24	42	diseases	disease	NOUN
dti-3495	24	43	(	(	PUNCT
dti-3495	24	44	4	4	NUM
dti-3495	24	45	)	)	PUNCT
dti-3495	24	46	.	.	PUNCT
dti-3495	25	1	the	the	DET
dti-3495	25	2	mortality	mortality	NOUN
dti-3495	25	3	rates	rate	NOUN
dti-3495	25	4	linked	link	VERB
dti-3495	25	5	to	to	ADP
dti-3495	25	6	t2	t2	NOUN
dti-3495	25	7	dm	dm	NUM
dti-3495	25	8	are	be	AUX
dti-3495	25	9	concerning	concern	VERB
dti-3495	25	10	,	,	PUNCT
dti-3495	25	11	since	since	SCONJ
dti-3495	25	12	it	it	PRON
dti-3495	25	13	leads	lead	VERB
dti-3495	25	14	to	to	ADP
dti-3495	25	15	cardiovascular	cardiovascular	ADJ
dti-3495	25	16	diseases	disease	NOUN
dti-3495	25	17	,	,	PUNCT
dti-3495	25	18	kidney	kidney	NOUN
dti-3495	25	19	failure	failure	NOUN
dti-3495	25	20	,	,	PUNCT
dti-3495	25	21	lower	low	ADJ
dti-3495	25	22	limb	limb	NOUN
dti-3495	25	23	amputation	amputation	NOUN
dti-3495	25	24	,	,	PUNCT
dti-3495	25	25	and	and	CCONJ
dti-3495	25	26	diabetic	diabetic	ADJ
dti-3495	25	27	retinopathy	retinopathy	NOUN
dti-3495	25	28	,	,	PUNCT
dti-3495	25	29	as	as	ADV
dti-3495	25	30	well	well	ADV
dti-3495	25	31	as	as	ADP
dti-3495	25	32	other	other	ADJ
dti-3495	25	33	complications	complication	NOUN
dti-3495	25	34	(	(	PUNCT
dti-3495	25	35	5	5	NUM
dti-3495	25	36	)	)	PUNCT
dti-3495	25	37	.	.	PUNCT
dti-3495	26	1	the	the	DET
dti-3495	26	2	mortality	mortality	NOUN
dti-3495	26	3	rate	rate	NOUN
dti-3495	26	4	linked	link	VERB
dti-3495	26	5	to	to	ADP
dti-3495	26	6	t2	t2	NOUN
dti-3495	26	7	dm	dm	PROPN
dti-3495	26	8	is	be	AUX
dti-3495	26	9	measured	measure	VERB
dti-3495	26	10	in	in	ADP
dti-3495	26	11	scientific	scientific	ADJ
dti-3495	26	12	research	research	NOUN
dti-3495	26	13	using	use	VERB
dti-3495	26	14	hazard	hazard	NOUN
dti-3495	26	15	ratios	ratio	NOUN
dti-3495	26	16	or	or	CCONJ
dti-3495	26	17	relative	relative	ADJ
dti-3495	26	18	risks	risk	NOUN
dti-3495	26	19	when	when	SCONJ
dti-3495	26	20	compared	compare	VERB
dti-3495	26	21	to	to	ADP
dti-3495	26	22	non	non	ADJ
dti-3495	26	23	-	-	ADJ
dti-3495	26	24	diabetic	diabetic	ADJ
dti-3495	26	25	groups	group	NOUN
dti-3495	26	26	.	.	PUNCT
dti-3495	27	1	for	for	ADP
dti-3495	27	2	example	example	NOUN
dti-3495	27	3	,	,	PUNCT
dti-3495	27	4	people	people	NOUN
dti-3495	27	5	with	with	ADP
dti-3495	27	6	t2	t2	NOUN
dti-3495	27	7	dm	dm	AUX
dti-3495	27	8	have	have	AUX
dti-3495	27	9	received	receive	VERB
dti-3495	27	10	:	:	PUNCT
dti-3495	27	11	february	february	PROPN
dti-3495	27	12	12	12	NUM
dti-3495	27	13	,	,	PUNCT
dti-3495	27	14	2025	2025	NUM
dti-3495	27	15	accepted	accept	VERB
dti-3495	27	16	:	:	PUNCT
dti-3495	27	17	june	june	PROPN
dti-3495	27	18	18	18	NUM
dti-3495	27	19	,	,	PUNCT
dti-3495	27	20	2025	2025	NUM
dti-3495	27	21	published	publish	VERB
dti-3495	27	22	online	online	ADV
dti-3495	27	23	:	:	PUNCT
dti-3495	27	24	august	august	PROPN
dti-3495	27	25	21	21	NUM
dti-3495	27	26	,	,	PUNCT
dti-3495	27	27	2025	2025	NUM
dti-3495	27	28	this	this	DET
dti-3495	27	29	article	article	NOUN
dti-3495	27	30	includes	include	VERB
dti-3495	27	31	supplementary	supplementary	ADJ
dti-3495	27	32	material	material	NOUN
dti-3495	27	33	.	.	PUNCT
dti-3495	28	1	corresponding	correspond	VERB
dti-3495	28	2	author	author	NOUN
dti-3495	28	3	:	:	PUNCT
dti-3495	28	4	haroon	haroon	PROPN
dti-3495	28	5	khan	khan	PROPN
dti-3495	28	6	email	email	NOUN
dti-3495	28	7	:	:	PUNCT
dti-3495	28	8	haroonkhan@awkum.edu.pk	haroonkhan@awkum.edu.pk	NOUN
dti-3495	28	9	;	;	PUNCT
dti-3495	28	10	haroonkhan@korea.ac.kr	haroonkhan@korea.ac.kr	NOUN
dti-3495	28	11	introduction	introduction	NOUN
dti-3495	28	12	type	type	NOUN
dti-3495	28	13	2	2	NUM
dti-3495	28	14	diabetes	diabetes	NOUN
dti-3495	28	15	mellitus	mellitus	NOUN
dti-3495	28	16	(	(	PUNCT
dti-3495	28	17	t2	t2	NOUN
dti-3495	28	18	dm	dm	NOUN
dti-3495	28	19	)	)	PUNCT
dti-3495	28	20	is	be	AUX
dti-3495	28	21	a	a	DET
dti-3495	28	22	growing	grow	VERB
dti-3495	28	23	and	and	CCONJ
dti-3495	28	24	important	important	ADJ
dti-3495	28	25	health	health	NOUN
dti-3495	28	26	issue	issue	NOUN
dti-3495	28	27	worldwide	worldwide	ADV
dti-3495	28	28	,	,	PUNCT
dti-3495	28	29	characterized	characterize	VERB
dti-3495	28	30	by	by	ADP
dti-3495	28	31	continuous	continuous	ADJ
dti-3495	28	32	high	high	ADJ
dti-3495	28	33	blood	blood	NOUN
dti-3495	28	34	sugar	sugar	NOUN
dti-3495	28	35	levels	level	NOUN
dti-3495	28	36	caused	cause	VERB
dti-3495	28	37	by	by	ADP
dti-3495	28	38	resistance	resistance	NOUN
dti-3495	28	39	to	to	ADP
dti-3495	28	40	insulin	insulin	NOUN
dti-3495	28	41	and	and	CCONJ
dti-3495	28	42	https://doi.org/10.33393/dti.2025.3495	https://doi.org/10.33393/dti.2025.3495	ADJ
dti-3495	28	43	https://creativecommons.org/licenses/by-nc/4.0/legalcode	https://creativecommons.org/licenses/by-nc/4.0/legalcode	NUM
dti-3495	28	44	https://orcid.org/0000-0001-5412-834x	https://orcid.org/0000-0001-5412-834x	NOUN
dti-3495	28	45	https://orcid.org/0000-0003-1940-2053	https://orcid.org/0000-0003-1940-2053	PROPN
dti-3495	28	46	https://orcid.org/0009-0004-4344-1145	https://orcid.org/0009-0004-4344-1145	PROPN
dti-3495	28	47	https://orcid.org/0000-0002-4870-7713	https://orcid.org/0000-0002-4870-7713	PROPN
dti-3495	28	48	mailto:haroonkhan@awkum.edu.pk	mailto:haroonkhan@awkum.edu.pk	PROPN
dti-3495	28	49	mailto	mailto	PROPN
dti-3495	28	50	:	:	PUNCT
dti-3495	28	51	haroonkhan%40korea.ac.kr?subject=	haroonkhan%40korea.ac.kr?subject=	NOUN
dti-3495	28	52	in	in	ADP
dti-3495	28	53	silico	silico	NOUN
dti-3495	28	54	anti	anti	ADJ
dti-3495	28	55	-	-	ADJ
dti-3495	28	56	diabetic	diabetic	ADJ
dti-3495	28	57	potential	potential	NOUN
dti-3495	28	58	of	of	ADP
dti-3495	28	59	vigna	vigna	PROPN
dti-3495	28	60	unguiculata72	unguiculata72	PROPN
dti-3495	29	1	©	©	ADP
dti-3495	29	2	2025	2025	NUM
dti-3495	29	3	the	the	DET
dti-3495	29	4	authors	author	NOUN
dti-3495	29	5	.	.	PUNCT
dti-3495	30	1	drug	drug	NOUN
dti-3495	30	2	target	target	NOUN
dti-3495	30	3	insights	insight	NOUN
dti-3495	30	4	issn	issn	VERB
dti-3495	30	5	1177	1177	NUM
dti-3495	30	6	-	-	SYM
dti-3495	30	7	3928	3928	NUM
dti-3495	30	8	www.aboutscience.eu/dti	www.aboutscience.eu/dti	VERB
dti-3495	30	9	double	double	DET
dti-3495	30	10	the	the	DET
dti-3495	30	11	likelihood	likelihood	NOUN
dti-3495	30	12	of	of	ADP
dti-3495	30	13	dying	die	VERB
dti-3495	30	14	at	at	ADP
dti-3495	30	15	any	any	DET
dti-3495	30	16	age	age	NOUN
dti-3495	30	17	compared	compare	VERB
dti-3495	30	18	to	to	ADP
dti-3495	30	19	those	those	PRON
dti-3495	30	20	without	without	ADP
dti-3495	30	21	the	the	DET
dti-3495	30	22	condition	condition	NOUN
dti-3495	30	23	.	.	PUNCT
dti-3495	31	1	treatment	treatment	NOUN
dti-3495	31	2	for	for	ADP
dti-3495	31	3	t2	t2	NOUN
dti-3495	31	4	dm	dm	PRON
dti-3495	31	5	mainly	mainly	ADV
dti-3495	31	6	focuses	focus	VERB
dti-3495	31	7	on	on	ADP
dti-3495	31	8	controlling	control	VERB
dti-3495	31	9	blood	blood	NOUN
dti-3495	31	10	sugar	sugar	NOUN
dti-3495	31	11	levels	level	NOUN
dti-3495	31	12	using	use	VERB
dti-3495	31	13	lifestyle	lifestyle	NOUN
dti-3495	31	14	changes	change	NOUN
dti-3495	31	15	,	,	PUNCT
dti-3495	31	16	oral	oral	ADJ
dti-3495	31	17	anti	anti	ADJ
dti-3495	31	18	-	-	ADJ
dti-3495	31	19	diabetic	diabetic	ADJ
dti-3495	31	20	medications	medication	NOUN
dti-3495	31	21	,	,	PUNCT
dti-3495	31	22	and	and	CCONJ
dti-3495	31	23	insulin	insulin	NOUN
dti-3495	31	24	treatment	treatment	NOUN
dti-3495	31	25	(	(	PUNCT
dti-3495	31	26	6	6	NUM
dti-3495	31	27	)	)	PUNCT
dti-3495	31	28	.	.	PUNCT
dti-3495	32	1	the	the	DET
dti-3495	32	2	methods	method	NOUN
dti-3495	32	3	mentioned	mention	VERB
dti-3495	32	4	typically	typically	ADV
dti-3495	32	5	do	do	AUX
dti-3495	32	6	not	not	PART
dti-3495	32	7	fully	fully	ADV
dti-3495	32	8	tackle	tackle	VERB
dti-3495	32	9	the	the	DET
dti-3495	32	10	multifaceted	multifaceted	ADJ
dti-3495	32	11	characteristics	characteristic	NOUN
dti-3495	32	12	of	of	ADP
dti-3495	32	13	the	the	DET
dti-3495	32	14	illness	illness	NOUN
dti-3495	32	15	.	.	PUNCT
dti-3495	33	1	many	many	ADJ
dti-3495	33	2	traditional	traditional	ADJ
dti-3495	33	3	treatments	treatment	NOUN
dti-3495	33	4	focus	focus	VERB
dti-3495	33	5	on	on	ADP
dti-3495	33	6	only	only	ADV
dti-3495	33	7	one	one	NUM
dti-3495	33	8	element	element	NOUN
dti-3495	33	9	of	of	ADP
dti-3495	33	10	the	the	DET
dti-3495	33	11	disease	disease	NOUN
dti-3495	33	12	’s	’s	PART
dti-3495	33	13	intricate	intricate	ADJ
dti-3495	33	14	pathophysiology	pathophysiology	NOUN
dti-3495	33	15	,	,	PUNCT
dti-3495	33	16	potentially	potentially	ADV
dti-3495	33	17	resulting	result	VERB
dti-3495	33	18	in	in	ADP
dti-3495	33	19	less	less	ADJ
dti-3495	33	20	than	than	ADP
dti-3495	33	21	ideal	ideal	ADJ
dti-3495	33	22	results	result	NOUN
dti-3495	33	23	and	and	CCONJ
dti-3495	33	24	failing	fail	VERB
dti-3495	33	25	to	to	PART
dti-3495	33	26	stop	stop	VERB
dti-3495	33	27	the	the	DET
dti-3495	33	28	advancement	advancement	NOUN
dti-3495	33	29	of	of	ADP
dti-3495	33	30	the	the	DET
dti-3495	33	31	disease	disease	NOUN
dti-3495	33	32	(	(	PUNCT
dti-3495	33	33	7	7	NUM
dti-3495	33	34	)	)	PUNCT
dti-3495	33	35	.	.	PUNCT
dti-3495	34	1	with	with	ADP
dti-3495	34	2	these	these	DET
dti-3495	34	3	restrictions	restriction	NOUN
dti-3495	34	4	in	in	ADP
dti-3495	34	5	mind	mind	NOUN
dti-3495	34	6	,	,	PUNCT
dti-3495	34	7	there	there	PRON
dti-3495	34	8	is	be	VERB
dti-3495	34	9	an	an	DET
dti-3495	34	10	urgent	urgent	ADJ
dti-3495	34	11	requirement	requirement	NOUN
dti-3495	34	12	for	for	ADP
dti-3495	34	13	a	a	DET
dti-3495	34	14	transition	transition	NOUN
dti-3495	34	15	towards	towards	ADP
dti-3495	34	16	multi	multi	ADJ
dti-3495	34	17	-	-	ADJ
dti-3495	34	18	target	target	ADJ
dti-3495	34	19	drug	drug	NOUN
dti-3495	34	20	discovery	discovery	NOUN
dti-3495	34	21	.	.	PUNCT
dti-3495	35	1	this	this	DET
dti-3495	35	2	method	method	NOUN
dti-3495	35	3	seeks	seek	VERB
dti-3495	35	4	to	to	PART
dti-3495	35	5	create	create	VERB
dti-3495	35	6	medications	medication	NOUN
dti-3495	35	7	that	that	PRON
dti-3495	35	8	can	can	AUX
dti-3495	35	9	concurrently	concurrently	ADV
dti-3495	35	10	impact	impact	VERB
dti-3495	35	11	numerous	numerous	ADJ
dti-3495	35	12	pathways	pathway	NOUN
dti-3495	35	13	associated	associate	VERB
dti-3495	35	14	with	with	ADP
dti-3495	35	15	t2	t2	PROPN
dti-3495	35	16	dm	dm	PROPN
dti-3495	35	17	,	,	PUNCT
dti-3495	35	18	providing	provide	VERB
dti-3495	35	19	a	a	DET
dti-3495	35	20	more	more	ADV
dti-3495	35	21	comprehensive	comprehensive	ADJ
dti-3495	35	22	treatment	treatment	NOUN
dti-3495	35	23	option	option	NOUN
dti-3495	35	24	.	.	PUNCT
dti-3495	36	1	these	these	DET
dti-3495	36	2	approaches	approach	NOUN
dti-3495	36	3	are	be	AUX
dti-3495	36	4	expected	expect	VERB
dti-3495	36	5	to	to	PART
dti-3495	36	6	enhance	enhance	VERB
dti-3495	36	7	treatment	treatment	NOUN
dti-3495	36	8	effectiveness	effectiveness	NOUN
dti-3495	36	9	and	and	CCONJ
dti-3495	36	10	patient	patient	ADJ
dti-3495	36	11	outcomes	outcome	NOUN
dti-3495	36	12	by	by	ADP
dti-3495	36	13	tackling	tackle	VERB
dti-3495	36	14	the	the	DET
dti-3495	36	15	various	various	ADJ
dti-3495	36	16	mechanisms	mechanism	NOUN
dti-3495	36	17	involved	involve	VERB
dti-3495	36	18	in	in	ADP
dti-3495	36	19	the	the	DET
dti-3495	36	20	development	development	NOUN
dti-3495	36	21	and	and	CCONJ
dti-3495	36	22	advancement	advancement	NOUN
dti-3495	36	23	of	of	ADP
dti-3495	36	24	the	the	DET
dti-3495	36	25	disease	disease	NOUN
dti-3495	36	26	.	.	PUNCT
dti-3495	37	1	therefore	therefore	ADV
dti-3495	37	2	,	,	PUNCT
dti-3495	37	3	t2	t2	PROPN
dti-3495	37	4	dm	dm	PROPN
dti-3495	37	5	continues	continue	VERB
dti-3495	37	6	to	to	PART
dti-3495	37	7	be	be	AUX
dti-3495	37	8	a	a	DET
dti-3495	37	9	significant	significant	ADJ
dti-3495	37	10	health	health	NOUN
dti-3495	37	11	challenge	challenge	NOUN
dti-3495	37	12	with	with	ADP
dti-3495	37	13	substantial	substantial	ADJ
dti-3495	37	14	morbidity	morbidity	NOUN
dti-3495	37	15	and	and	CCONJ
dti-3495	37	16	mortality	mortality	NOUN
dti-3495	37	17	.	.	PUNCT
dti-3495	38	1	the	the	DET
dti-3495	38	2	insufficiency	insufficiency	NOUN
dti-3495	38	3	of	of	ADP
dti-3495	38	4	current	current	ADJ
dti-3495	38	5	single	single	ADJ
dti-3495	38	6	-	-	PUNCT
dti-3495	38	7	target	target	NOUN
dti-3495	38	8	treatments	treatment	NOUN
dti-3495	38	9	emphasizes	emphasize	VERB
dti-3495	38	10	the	the	DET
dti-3495	38	11	need	need	NOUN
dti-3495	38	12	for	for	ADP
dti-3495	38	13	innovative	innovative	ADJ
dti-3495	38	14	treatment	treatment	NOUN
dti-3495	38	15	approaches	approach	NOUN
dti-3495	38	16	,	,	PUNCT
dti-3495	38	17	especially	especially	ADV
dti-3495	38	18	those	those	PRON
dti-3495	38	19	involving	involve	VERB
dti-3495	38	20	multi	multi	ADJ
dti-3495	38	21	-	-	ADJ
dti-3495	38	22	target	target	NOUN
dti-3495	38	23	interventions	intervention	NOUN
dti-3495	38	24	,	,	PUNCT
dti-3495	38	25	to	to	AUX
dti-3495	38	26	more	more	ADV
dti-3495	38	27	effectively	effectively	ADV
dti-3495	38	28	handle	handle	VERB
dti-3495	38	29	and	and	CCONJ
dti-3495	38	30	potentially	potentially	ADV
dti-3495	38	31	reverse	reverse	VERB
dti-3495	38	32	this	this	DET
dti-3495	38	33	intricate	intricate	ADJ
dti-3495	38	34	and	and	CCONJ
dti-3495	38	35	widespread	widespread	ADJ
dti-3495	38	36	disease	disease	NOUN
dti-3495	38	37	.	.	PUNCT
dti-3495	39	1	conventional	conventional	ADJ
dti-3495	39	2	treatments	treatment	NOUN
dti-3495	39	3	primarily	primarily	ADV
dti-3495	39	4	focus	focus	VERB
dti-3495	39	5	on	on	ADP
dti-3495	39	6	managing	manage	VERB
dti-3495	39	7	blood	blood	NOUN
dti-3495	39	8	glucose	glucose	NOUN
dti-3495	39	9	levels	level	NOUN
dti-3495	39	10	and	and	CCONJ
dti-3495	39	11	mitigating	mitigate	VERB
dti-3495	39	12	symptoms	symptom	NOUN
dti-3495	39	13	,	,	PUNCT
dti-3495	39	14	yet	yet	CCONJ
dti-3495	39	15	they	they	PRON
dti-3495	39	16	often	often	ADV
dti-3495	39	17	fail	fail	VERB
dti-3495	39	18	to	to	PART
dti-3495	39	19	address	address	VERB
dti-3495	39	20	the	the	DET
dti-3495	39	21	underlying	underlie	VERB
dti-3495	39	22	causes	cause	NOUN
dti-3495	39	23	and	and	CCONJ
dti-3495	39	24	multiple	multiple	ADJ
dti-3495	39	25	pathways	pathway	NOUN
dti-3495	39	26	involved	involve	VERB
dti-3495	39	27	in	in	ADP
dti-3495	39	28	the	the	DET
dti-3495	39	29	disease	disease	NOUN
dti-3495	39	30	’s	’s	PART
dti-3495	39	31	progression	progression	NOUN
dti-3495	39	32	.	.	PUNCT
dti-3495	40	1	recent	recent	ADJ
dti-3495	40	2	advancements	advancement	NOUN
dti-3495	40	3	in	in	ADP
dti-3495	40	4	network	network	NOUN
dti-3495	40	5	pharmacology	pharmacology	NOUN
dti-3495	40	6	have	have	AUX
dti-3495	40	7	underscored	underscore	VERB
dti-3495	40	8	the	the	DET
dti-3495	40	9	importance	importance	NOUN
dti-3495	40	10	of	of	ADP
dti-3495	40	11	targeting	target	VERB
dti-3495	40	12	multiple	multiple	ADJ
dti-3495	40	13	biological	biological	ADJ
dti-3495	40	14	pathways	pathway	NOUN
dti-3495	40	15	simultaneously	simultaneously	ADV
dti-3495	40	16	to	to	PART
dti-3495	40	17	achieve	achieve	VERB
dti-3495	40	18	more	more	ADV
dti-3495	40	19	effective	effective	ADJ
dti-3495	40	20	therapeutic	therapeutic	ADJ
dti-3495	40	21	outcomes	outcome	NOUN
dti-3495	40	22	.	.	PUNCT
dti-3495	41	1	network	network	NOUN
dti-3495	41	2	pharmacology	pharmacology	NOUN
dti-3495	41	3	is	be	AUX
dti-3495	41	4	a	a	DET
dti-3495	41	5	cutting	cut	VERB
dti-3495	41	6	-	-	PUNCT
dti-3495	41	7	edge	edge	NOUN
dti-3495	41	8	approach	approach	NOUN
dti-3495	41	9	that	that	PRON
dti-3495	41	10	integrates	integrate	VERB
dti-3495	41	11	systems	system	NOUN
dti-3495	41	12	biology	biology	NOUN
dti-3495	41	13	,	,	PUNCT
dti-3495	41	14	multi	multi	ADJ
dti-3495	41	15	-	-	ADJ
dti-3495	41	16	target	target	ADJ
dti-3495	41	17	drug	drug	NOUN
dti-3495	41	18	actions	action	NOUN
dti-3495	41	19	,	,	PUNCT
dti-3495	41	20	and	and	CCONJ
dti-3495	41	21	bioinformatics	bioinformatics	NOUN
dti-3495	41	22	to	to	PART
dti-3495	41	23	systematically	systematically	ADV
dti-3495	41	24	explore	explore	VERB
dti-3495	41	25	the	the	DET
dti-3495	41	26	therapeutic	therapeutic	ADJ
dti-3495	41	27	potential	potential	NOUN
dti-3495	41	28	of	of	ADP
dti-3495	41	29	drugs	drug	NOUN
dti-3495	41	30	,	,	PUNCT
dti-3495	41	31	including	include	VERB
dti-3495	41	32	those	those	PRON
dti-3495	41	33	derived	derive	VERB
dti-3495	41	34	from	from	ADP
dti-3495	41	35	medicinal	medicinal	ADJ
dti-3495	41	36	plants	plant	NOUN
dti-3495	41	37	(	(	PUNCT
dti-3495	41	38	8,9	8,9	NUM
dti-3495	41	39	)	)	PUNCT
dti-3495	41	40	.	.	PUNCT
dti-3495	42	1	this	this	DET
dti-3495	42	2	approach	approach	NOUN
dti-3495	42	3	is	be	AUX
dti-3495	42	4	especially	especially	ADV
dti-3495	42	5	relevant	relevant	ADJ
dti-3495	42	6	in	in	ADP
dti-3495	42	7	the	the	DET
dti-3495	42	8	context	context	NOUN
dti-3495	42	9	of	of	ADP
dti-3495	42	10	t2	t2	PROPN
dti-3495	42	11	dm	dm	PROPN
dti-3495	42	12	,	,	PUNCT
dti-3495	42	13	where	where	SCONJ
dti-3495	42	14	the	the	DET
dti-3495	42	15	interplay	interplay	NOUN
dti-3495	42	16	between	between	ADP
dti-3495	42	17	insulin	insulin	NOUN
dti-3495	42	18	signaling	signaling	NOUN
dti-3495	42	19	,	,	PUNCT
dti-3495	42	20	inflammation	inflammation	NOUN
dti-3495	42	21	,	,	PUNCT
dti-3495	42	22	and	and	CCONJ
dti-3495	42	23	oxidative	oxidative	ADJ
dti-3495	42	24	stress	stress	NOUN
dti-3495	42	25	contributes	contribute	VERB
dti-3495	42	26	to	to	ADP
dti-3495	42	27	the	the	DET
dti-3495	42	28	disease	disease	NOUN
dti-3495	42	29	’s	’s	PART
dti-3495	42	30	complexity	complexity	NOUN
dti-3495	42	31	.	.	PUNCT
dti-3495	43	1	in	in	ADP
dti-3495	43	2	this	this	DET
dti-3495	43	3	study	study	NOUN
dti-3495	43	4	,	,	PUNCT
dti-3495	43	5	we	we	PRON
dti-3495	43	6	explore	explore	VERB
dti-3495	43	7	the	the	DET
dti-3495	43	8	potential	potential	NOUN
dti-3495	43	9	of	of	ADP
dti-3495	43	10	v.	v.	ADP
dti-3495	43	11	unguiculata	unguiculata	PROPN
dti-3495	43	12	,	,	PUNCT
dti-3495	43	13	a	a	DET
dti-3495	43	14	plant	plant	NOUN
dti-3495	43	15	with	with	ADP
dti-3495	43	16	a	a	DET
dti-3495	43	17	rich	rich	ADJ
dti-3495	43	18	history	history	NOUN
dti-3495	43	19	in	in	ADP
dti-3495	43	20	traditional	traditional	ADJ
dti-3495	43	21	medicine	medicine	NOUN
dti-3495	43	22	,	,	PUNCT
dti-3495	43	23	as	as	ADP
dti-3495	43	24	a	a	DET
dti-3495	43	25	source	source	NOUN
dti-3495	43	26	of	of	ADP
dti-3495	43	27	multitarget	multitarget	PROPN
dti-3495	43	28	anti	anti	ADJ
dti-3495	43	29	-	-	ADJ
dti-3495	43	30	diabetic	diabetic	ADJ
dti-3495	43	31	agents	agent	NOUN
dti-3495	43	32	.	.	PUNCT
dti-3495	44	1	v.	v.	ADP
dti-3495	44	2	unguiculata	unguiculata	PROPN
dti-3495	44	3	(	(	PUNCT
dti-3495	44	4	commonly	commonly	ADV
dti-3495	44	5	known	know	VERB
dti-3495	44	6	as	as	ADP
dti-3495	44	7	cowpea	cowpea	NOUN
dti-3495	44	8	or	or	CCONJ
dti-3495	44	9	lobia	lobia	NOUN
dti-3495	44	10	)	)	PUNCT
dti-3495	44	11	is	be	AUX
dti-3495	44	12	a	a	DET
dti-3495	44	13	leguminous	leguminous	ADJ
dti-3495	44	14	plant	plant	NOUN
dti-3495	44	15	belonging	belong	VERB
dti-3495	44	16	to	to	ADP
dti-3495	44	17	the	the	DET
dti-3495	44	18	fabaceae	fabaceae	PROPN
dti-3495	44	19	family	family	NOUN
dti-3495	44	20	(	(	PUNCT
dti-3495	44	21	10	10	NUM
dti-3495	44	22	)	)	PUNCT
dti-3495	44	23	.	.	PUNCT
dti-3495	45	1	traditionally	traditionally	ADV
dti-3495	45	2	used	use	VERB
dti-3495	45	3	in	in	ADP
dti-3495	45	4	various	various	ADJ
dti-3495	45	5	medicinal	medicinal	ADJ
dti-3495	45	6	practices	practice	NOUN
dti-3495	45	7	,	,	PUNCT
dti-3495	45	8	it	it	PRON
dti-3495	45	9	has	have	AUX
dti-3495	45	10	been	be	AUX
dti-3495	45	11	suggested	suggest	VERB
dti-3495	45	12	to	to	PART
dti-3495	45	13	possess	possess	VERB
dti-3495	45	14	anti	anti	ADJ
dti-3495	45	15	-	-	ADJ
dti-3495	45	16	diabetic	diabetic	ADJ
dti-3495	45	17	properties	property	NOUN
dti-3495	45	18	,	,	PUNCT
dti-3495	45	19	potentially	potentially	ADV
dti-3495	45	20	due	due	ADP
dti-3495	45	21	to	to	ADP
dti-3495	45	22	its	its	PRON
dti-3495	45	23	bioactive	bioactive	ADJ
dti-3495	45	24	compounds	compound	NOUN
dti-3495	45	25	that	that	PRON
dti-3495	45	26	may	may	AUX
dti-3495	45	27	influence	influence	VERB
dti-3495	45	28	glucose	glucose	NOUN
dti-3495	45	29	metabolism	metabolism	NOUN
dti-3495	45	30	and	and	CCONJ
dti-3495	45	31	insulin	insulin	NOUN
dti-3495	45	32	sensitivity	sensitivity	NOUN
dti-3495	45	33	(	(	PUNCT
dti-3495	45	34	11,12	11,12	NUM
dti-3495	45	35	)	)	PUNCT
dti-3495	45	36	.	.	PUNCT
dti-3495	46	1	however	however	ADV
dti-3495	46	2	,	,	PUNCT
dti-3495	46	3	the	the	DET
dti-3495	46	4	exact	exact	ADJ
dti-3495	46	5	mechanism	mechanism	NOUN
dti-3495	46	6	is	be	AUX
dti-3495	46	7	currently	currently	ADV
dti-3495	46	8	unknown	unknown	ADJ
dti-3495	46	9	.	.	PUNCT
dti-3495	47	1	following	follow	VERB
dti-3495	47	2	that	that	PRON
dti-3495	47	3	,	,	PUNCT
dti-3495	47	4	this	this	DET
dti-3495	47	5	study	study	NOUN
dti-3495	47	6	provides	provide	VERB
dti-3495	47	7	compelling	compelling	ADJ
dti-3495	47	8	evidence	evidence	NOUN
dti-3495	47	9	for	for	ADP
dti-3495	47	10	the	the	DET
dti-3495	47	11	anti	anti	ADJ
dti-3495	47	12	-	-	ADJ
dti-3495	47	13	diabetic	diabetic	ADJ
dti-3495	47	14	potential	potential	NOUN
dti-3495	47	15	of	of	ADP
dti-3495	47	16	v.	v.	X
dti-3495	47	17	unguiculata	unguiculata	ADJ
dti-3495	47	18	through	through	ADP
dti-3495	47	19	an	an	DET
dti-3495	47	20	integrated	integrated	ADJ
dti-3495	47	21	approach	approach	NOUN
dti-3495	47	22	that	that	PRON
dti-3495	47	23	combines	combine	VERB
dti-3495	47	24	traditional	traditional	ADJ
dti-3495	47	25	knowledge	knowledge	NOUN
dti-3495	47	26	with	with	ADP
dti-3495	47	27	modern	modern	ADJ
dti-3495	47	28	scientific	scientific	ADJ
dti-3495	47	29	techniques	technique	NOUN
dti-3495	47	30	.	.	PUNCT
dti-3495	48	1	the	the	DET
dti-3495	48	2	study	study	NOUN
dti-3495	48	3	highlights	highlight	VERB
dti-3495	48	4	the	the	DET
dti-3495	48	5	importance	importance	NOUN
dti-3495	48	6	of	of	ADP
dti-3495	48	7	a	a	DET
dti-3495	48	8	multi	multi	ADJ
dti-3495	48	9	-	-	ADJ
dti-3495	48	10	target	target	ADJ
dti-3495	48	11	therapeutic	therapeutic	ADJ
dti-3495	48	12	strategy	strategy	NOUN
dti-3495	48	13	,	,	PUNCT
dti-3495	48	14	particularly	particularly	ADV
dti-3495	48	15	in	in	ADP
dti-3495	48	16	managing	manage	VERB
dti-3495	48	17	complex	complex	ADJ
dti-3495	48	18	diseases	disease	NOUN
dti-3495	48	19	like	like	ADP
dti-3495	48	20	t2	t2	NOUN
dti-3495	48	21	dm	dm	NOUN
dti-3495	48	22	,	,	PUNCT
dti-3495	48	23	where	where	SCONJ
dti-3495	48	24	multiple	multiple	ADJ
dti-3495	48	25	biological	biological	ADJ
dti-3495	48	26	processes	process	NOUN
dti-3495	48	27	are	be	AUX
dti-3495	48	28	dysregulated	dysregulate	VERB
dti-3495	48	29	.	.	PUNCT
dti-3495	49	1	the	the	DET
dti-3495	49	2	v.	v.	PROPN
dti-3495	49	3	unguiculata	unguiculata	PROPN
dti-3495	49	4	has	have	AUX
dti-3495	49	5	been	be	AUX
dti-3495	49	6	traditionally	traditionally	ADV
dti-3495	49	7	employed	employ	VERB
dti-3495	49	8	for	for	ADP
dti-3495	49	9	the	the	DET
dti-3495	49	10	ailment	ailment	NOUN
dti-3495	49	11	of	of	ADP
dti-3495	49	12	various	various	ADJ
dti-3495	49	13	diseases	disease	NOUN
dti-3495	49	14	,	,	PUNCT
dti-3495	49	15	including	include	VERB
dti-3495	49	16	dm	dm	PROPN
dti-3495	49	17	.	.	PUNCT
dti-3495	50	1	however	however	ADV
dti-3495	50	2	,	,	PUNCT
dti-3495	50	3	the	the	DET
dti-3495	50	4	mechanism	mechanism	NOUN
dti-3495	50	5	by	by	ADP
dti-3495	50	6	which	which	PRON
dti-3495	50	7	v.	v.	CCONJ
dti-3495	50	8	unguiculata	unguiculata	VERB
dti-3495	50	9	exhibits	exhibit	VERB
dti-3495	50	10	anti	anti	ADJ
dti-3495	50	11	-	-	ADJ
dti-3495	50	12	diabetic	diabetic	ADJ
dti-3495	50	13	activity	activity	NOUN
dti-3495	50	14	has	have	AUX
dti-3495	50	15	not	not	PART
dti-3495	50	16	been	be	AUX
dti-3495	50	17	explored	explore	VERB
dti-3495	50	18	.	.	PUNCT
dti-3495	51	1	based	base	VERB
dti-3495	51	2	on	on	ADP
dti-3495	51	3	the	the	DET
dti-3495	51	4	previously	previously	ADV
dti-3495	51	5	reported	report	VERB
dti-3495	51	6	activities	activity	NOUN
dti-3495	51	7	,	,	PUNCT
dti-3495	51	8	the	the	DET
dti-3495	51	9	bioactive	bioactive	ADJ
dti-3495	51	10	extract	extract	NOUN
dti-3495	51	11	of	of	ADP
dti-3495	51	12	the	the	DET
dti-3495	51	13	v.	v.	PROPN
dti-3495	51	14	unguiculata	unguiculata	PROPN
dti-3495	51	15	has	have	AUX
dti-3495	51	16	been	be	AUX
dti-3495	51	17	evaluated	evaluate	VERB
dti-3495	51	18	against	against	ADP
dti-3495	51	19	dm	dm	PROPN
dti-3495	51	20	using	use	VERB
dti-3495	51	21	in	in	ADP
dti-3495	51	22	vitro	vitro	X
dti-3495	51	23	studies	study	NOUN
dti-3495	51	24	,	,	PUNCT
dti-3495	51	25	network	network	NOUN
dti-3495	51	26	pharmacology	pharmacology	NOUN
dti-3495	51	27	,	,	PUNCT
dti-3495	51	28	molecular	molecular	ADJ
dti-3495	51	29	docking	docking	NOUN
dti-3495	51	30	,	,	PUNCT
dti-3495	51	31	md	md	PROPN
dti-3495	51	32	simulation	simulation	NOUN
dti-3495	51	33	,	,	PUNCT
dti-3495	51	34	and	and	CCONJ
dti-3495	51	35	binding	bind	VERB
dti-3495	51	36	free	free	ADJ
dti-3495	51	37	energies	energy	NOUN
dti-3495	51	38	with	with	ADP
dti-3495	51	39	the	the	DET
dti-3495	51	40	intention	intention	NOUN
dti-3495	51	41	to	to	PART
dti-3495	51	42	explore	explore	VERB
dti-3495	51	43	the	the	DET
dti-3495	51	44	potential	potential	ADJ
dti-3495	51	45	anti	anti	ADJ
dti-3495	51	46	-	-	ADJ
dti-3495	51	47	diabetic	diabetic	ADJ
dti-3495	51	48	mechanism	mechanism	NOUN
dti-3495	51	49	.	.	PUNCT
dti-3495	52	1	in	in	ADP
dti-3495	52	2	this	this	DET
dti-3495	52	3	study	study	NOUN
dti-3495	52	4	,	,	PUNCT
dti-3495	52	5	the	the	DET
dti-3495	52	6	key	key	ADJ
dti-3495	52	7	approach	approach	NOUN
dti-3495	52	8	was	be	AUX
dti-3495	52	9	adopted	adopt	VERB
dti-3495	52	10	to	to	PART
dti-3495	52	11	explore	explore	VERB
dti-3495	52	12	the	the	DET
dti-3495	52	13	pathways	pathway	NOUN
dti-3495	52	14	,	,	PUNCT
dti-3495	52	15	which	which	PRON
dti-3495	52	16	plays	play	VERB
dti-3495	52	17	crucial	crucial	ADJ
dti-3495	52	18	role	role	NOUN
dti-3495	52	19	in	in	ADP
dti-3495	52	20	the	the	DET
dti-3495	52	21	pathogenesis	pathogenesis	NOUN
dti-3495	52	22	of	of	ADP
dti-3495	52	23	the	the	DET
dti-3495	52	24	dm	dm	PROPN
dti-3495	52	25	,	,	PUNCT
dti-3495	52	26	i.e.	i.e.	X
dti-3495	52	27	,	,	PUNCT
dti-3495	52	28	by	by	ADP
dti-3495	52	29	inducing	induce	VERB
dti-3495	52	30	damage	damage	NOUN
dti-3495	52	31	to	to	ADP
dti-3495	52	32	the	the	DET
dti-3495	52	33	insulin	insulin	NOUN
dti-3495	52	34	producing	produce	VERB
dti-3495	52	35	cells	cell	NOUN
dti-3495	52	36	and	and	CCONJ
dti-3495	52	37	confer	confer	VERB
dti-3495	52	38	insulin	insulin	NOUN
dti-3495	52	39	resistance	resistance	NOUN
dti-3495	52	40	such	such	ADJ
dti-3495	52	41	as	as	ADP
dti-3495	52	42	ptgs2	ptgs2	PROPN
dti-3495	52	43	,	,	PUNCT
dti-3495	52	44	glycogen	glycogen	NOUN
dti-3495	52	45	synthases	synthase	NOUN
dti-3495	52	46	kinase	kinase	VERB
dti-3495	52	47	3	3	NUM
dti-3495	52	48	beta	beta	NOUN
dti-3495	52	49	(	(	PUNCT
dti-3495	52	50	gsk3b	gsk3b	PROPN
dti-3495	52	51	)	)	PUNCT
dti-3495	52	52	and	and	CCONJ
dti-3495	52	53	toll	toll	NOUN
dti-3495	52	54	-	-	PUNCT
dti-3495	52	55	like	like	ADJ
dti-3495	52	56	receptor-4	receptor-4	NOUN
dti-3495	52	57	(	(	PUNCT
dti-3495	52	58	tlr-4	tlr-4	X
dti-3495	52	59	)	)	PUNCT
dti-3495	52	60	signaling	signal	VERB
dti-3495	52	61	(	(	PUNCT
dti-3495	52	62	13	13	NUM
dti-3495	52	63	-	-	SYM
dti-3495	52	64	15	15	NUM
dti-3495	52	65	)	)	PUNCT
dti-3495	52	66	.	.	PUNCT
dti-3495	53	1	the	the	DET
dti-3495	53	2	gsk3b	gsk3b	PROPN
dti-3495	53	3	has	have	AUX
dti-3495	53	4	been	be	AUX
dti-3495	53	5	focused	focus	VERB
dti-3495	53	6	recently	recently	ADV
dti-3495	53	7	on	on	ADP
dti-3495	53	8	diabetes	diabetes	NOUN
dti-3495	53	9	management	management	NOUN
dti-3495	53	10	due	due	ADP
dti-3495	53	11	to	to	ADP
dti-3495	53	12	its	its	PRON
dti-3495	53	13	involvement	involvement	NOUN
dti-3495	53	14	in	in	ADP
dti-3495	53	15	insulin	insulin	NOUN
dti-3495	53	16	resistance	resistance	NOUN
dti-3495	53	17	,	,	PUNCT
dti-3495	53	18	insulin	insulin	NOUN
dti-3495	53	19	synthesis	synthesis	NOUN
dti-3495	53	20	,	,	PUNCT
dti-3495	53	21	and	and	CCONJ
dti-3495	53	22	protection	protection	NOUN
dti-3495	53	23	of	of	ADP
dti-3495	53	24	the	the	DET
dti-3495	53	25	b	b	NOUN
dti-3495	53	26	-	-	PUNCT
dti-3495	53	27	cells	cell	NOUN
dti-3495	53	28	(	(	PUNCT
dti-3495	53	29	islet	islet	NOUN
dti-3495	53	30	of	of	ADP
dti-3495	53	31	langerhans	langerhans	ADJ
dti-3495	53	32	cells	cell	NOUN
dti-3495	53	33	)	)	PUNCT
dti-3495	53	34	.	.	PUNCT
dti-3495	54	1	similarly	similarly	ADV
dti-3495	54	2	,	,	PUNCT
dti-3495	54	3	the	the	DET
dti-3495	54	4	role	role	NOUN
dti-3495	54	5	of	of	ADP
dti-3495	54	6	tlr-4	tlr-4	PRON
dti-3495	54	7	has	have	AUX
dti-3495	54	8	also	also	ADV
dti-3495	54	9	been	be	AUX
dti-3495	54	10	implicated	implicate	VERB
dti-3495	54	11	in	in	ADP
dti-3495	54	12	the	the	DET
dti-3495	54	13	pathogenesis	pathogenesis	NOUN
dti-3495	54	14	of	of	ADP
dti-3495	54	15	various	various	ADJ
dti-3495	54	16	diseases	disease	NOUN
dti-3495	54	17	,	,	PUNCT
dti-3495	54	18	including	include	VERB
dti-3495	54	19	diabetes	diabetes	NOUN
dti-3495	54	20	;	;	PUNCT
dti-3495	54	21	enhanced	enhance	VERB
dti-3495	54	22	tlr-4	tlr-4	DET
dti-3495	54	23	activity	activity	NOUN
dti-3495	54	24	paves	pave	VERB
dti-3495	54	25	the	the	DET
dti-3495	54	26	way	way	NOUN
dti-3495	54	27	for	for	ADP
dti-3495	54	28	inflammation	inflammation	NOUN
dti-3495	54	29	of	of	ADP
dti-3495	54	30	various	various	ADJ
dti-3495	54	31	tissues	tissue	NOUN
dti-3495	54	32	,	,	PUNCT
dti-3495	54	33	including	include	VERB
dti-3495	54	34	the	the	DET
dti-3495	54	35	pancreas	pancrea	NOUN
dti-3495	54	36	,	,	PUNCT
dti-3495	54	37	and	and	CCONJ
dti-3495	54	38	cross	cross	NOUN
dti-3495	54	39	-	-	NOUN
dti-3495	54	40	talk	talk	NOUN
dti-3495	54	41	with	with	ADP
dti-3495	54	42	multiple	multiple	ADJ
dti-3495	54	43	signaling	signal	VERB
dti-3495	54	44	pathways	pathway	NOUN
dti-3495	54	45	such	such	ADJ
dti-3495	54	46	as	as	ADP
dti-3495	54	47	mapks	mapks	NOUN
dti-3495	54	48	,	,	PUNCT
dti-3495	54	49	nf	nf	PROPN
dti-3495	54	50	-	-	PUNCT
dti-3495	54	51	kb	kb	NOUN
dti-3495	54	52	,	,	PUNCT
dti-3495	54	53	and	and	CCONJ
dti-3495	54	54	jak	jak	PROPN
dti-3495	54	55	/	/	SYM
dti-3495	54	56	stat	stat	PROPN
dti-3495	54	57	signaling	signal	VERB
dti-3495	54	58	(	(	PUNCT
dti-3495	54	59	16,17	16,17	NUM
dti-3495	54	60	)	)	PUNCT
dti-3495	54	61	.	.	PUNCT
dti-3495	55	1	primarily	primarily	ADV
dti-3495	55	2	,	,	PUNCT
dti-3495	55	3	in	in	ADP
dti-3495	55	4	this	this	DET
dti-3495	55	5	study	study	NOUN
dti-3495	55	6	,	,	PUNCT
dti-3495	55	7	v.	v.	SCONJ
dti-3495	55	8	unguiculata	unguiculata	ADJ
dti-3495	55	9	plant	plant	NOUN
dti-3495	55	10	bioactive	bioactive	NOUN
dti-3495	55	11	compounds	compound	NOUN
dti-3495	55	12	were	be	AUX
dti-3495	55	13	employed	employ	VERB
dti-3495	55	14	against	against	ADP
dti-3495	55	15	the	the	DET
dti-3495	55	16	multiple	multiple	ADJ
dti-3495	55	17	signaling	signal	VERB
dti-3495	55	18	pathways	pathway	NOUN
dti-3495	55	19	involved	involve	VERB
dti-3495	55	20	in	in	ADP
dti-3495	55	21	diabetes	diabetes	NOUN
dti-3495	55	22	pathogenesis	pathogenesis	NOUN
dti-3495	55	23	.	.	PUNCT
dti-3495	56	1	by	by	ADP
dti-3495	56	2	employing	employ	VERB
dti-3495	56	3	comprehensive	comprehensive	ADJ
dti-3495	56	4	computational	computational	ADJ
dti-3495	56	5	approaches	approach	NOUN
dti-3495	56	6	,	,	PUNCT
dti-3495	56	7	it	it	PRON
dti-3495	56	8	was	be	AUX
dti-3495	56	9	assumed	assume	VERB
dti-3495	56	10	that	that	SCONJ
dti-3495	56	11	bioactive	bioactive	VERB
dti-3495	56	12	compounds	compound	NOUN
dti-3495	56	13	from	from	ADP
dti-3495	56	14	the	the	DET
dti-3495	56	15	v.	v.	PROPN
dti-3495	56	16	unguiculata	unguiculata	PROPN
dti-3495	56	17	interact	interact	PROPN
dti-3495	56	18	with	with	ADP
dti-3495	56	19	the	the	DET
dti-3495	56	20	multiple	multiple	ADJ
dti-3495	56	21	biological	biological	ADJ
dti-3495	56	22	signaling	signal	VERB
dti-3495	56	23	pathways	pathway	NOUN
dti-3495	56	24	concerned	concern	VERB
dti-3495	56	25	with	with	ADP
dti-3495	56	26	glucose	glucose	NOUN
dti-3495	56	27	metabolism	metabolism	NOUN
dti-3495	56	28	,	,	PUNCT
dti-3495	56	29	insulin	insulin	NOUN
dti-3495	56	30	resistance	resistance	NOUN
dti-3495	56	31	,	,	PUNCT
dti-3495	56	32	and	and	CCONJ
dti-3495	56	33	the	the	DET
dti-3495	56	34	inflammatory	inflammatory	ADJ
dti-3495	56	35	process	process	NOUN
dti-3495	56	36	,	,	PUNCT
dti-3495	56	37	which	which	PRON
dti-3495	56	38	will	will	AUX
dti-3495	56	39	eventually	eventually	ADV
dti-3495	56	40	improve	improve	VERB
dti-3495	56	41	diabetes	diabetes	NOUN
dti-3495	56	42	symptoms	symptom	NOUN
dti-3495	56	43	by	by	ADP
dti-3495	56	44	regulating	regulate	VERB
dti-3495	56	45	the	the	DET
dti-3495	56	46	blood	blood	NOUN
dti-3495	56	47	glucose	glucose	NOUN
dti-3495	56	48	level	level	NOUN
dti-3495	56	49	(	(	PUNCT
dti-3495	56	50	13	13	NUM
dti-3495	56	51	-	-	SYM
dti-3495	56	52	15	15	NUM
dti-3495	56	53	)	)	PUNCT
dti-3495	56	54	.	.	PUNCT
dti-3495	57	1	currently	currently	ADV
dti-3495	57	2	,	,	PUNCT
dti-3495	57	3	several	several	ADJ
dti-3495	57	4	classes	class	NOUN
dti-3495	57	5	of	of	ADP
dti-3495	57	6	anti	anti	ADJ
dti-3495	57	7	-	-	ADJ
dti-3495	57	8	diabetic	diabetic	ADJ
dti-3495	57	9	drugs	drug	NOUN
dti-3495	57	10	are	be	AUX
dti-3495	57	11	in	in	ADP
dti-3495	57	12	clinical	clinical	ADJ
dti-3495	57	13	practice	practice	NOUN
dti-3495	57	14	for	for	ADP
dti-3495	57	15	the	the	DET
dti-3495	57	16	management	management	NOUN
dti-3495	57	17	of	of	ADP
dti-3495	57	18	dm	dm	PROPN
dti-3495	57	19	.	.	PUNCT
dti-3495	58	1	however	however	ADV
dti-3495	58	2	,	,	PUNCT
dti-3495	58	3	the	the	DET
dti-3495	58	4	existing	exist	VERB
dti-3495	58	5	drugs	drug	NOUN
dti-3495	58	6	are	be	AUX
dti-3495	58	7	associated	associate	VERB
dti-3495	58	8	with	with	ADP
dti-3495	58	9	various	various	ADJ
dti-3495	58	10	unwanted	unwanted	ADJ
dti-3495	58	11	side	side	NOUN
dti-3495	58	12	effects	effect	NOUN
dti-3495	58	13	such	such	ADJ
dti-3495	58	14	as	as	ADP
dti-3495	58	15	weight	weight	NOUN
dti-3495	58	16	gain	gain	NOUN
dti-3495	58	17	,	,	PUNCT
dti-3495	58	18	lactic	lactic	ADJ
dti-3495	58	19	acidosis	acidosis	NOUN
dti-3495	58	20	,	,	PUNCT
dti-3495	58	21	urinary	urinary	ADJ
dti-3495	58	22	tract	tract	NOUN
dti-3495	58	23	infections	infection	NOUN
dti-3495	58	24	,	,	PUNCT
dti-3495	58	25	and	and	CCONJ
dti-3495	58	26	the	the	DET
dti-3495	58	27	cases	case	NOUN
dti-3495	58	28	of	of	ADP
dti-3495	58	29	dm	dm	NUM
dti-3495	58	30	are	be	AUX
dti-3495	58	31	increasing	increase	VERB
dti-3495	58	32	globally	globally	ADV
dti-3495	58	33	.	.	PUNCT
dti-3495	59	1	thus	thus	ADV
dti-3495	59	2	,	,	PUNCT
dti-3495	59	3	there	there	PRON
dti-3495	59	4	is	be	VERB
dti-3495	59	5	a	a	DET
dti-3495	59	6	need	need	NOUN
dti-3495	59	7	for	for	ADP
dti-3495	59	8	the	the	DET
dti-3495	59	9	exploration	exploration	NOUN
dti-3495	59	10	of	of	ADP
dti-3495	59	11	new	new	ADJ
dti-3495	59	12	drugs	drug	NOUN
dti-3495	59	13	,	,	PUNCT
dti-3495	59	14	which	which	PRON
dti-3495	59	15	are	be	AUX
dti-3495	59	16	not	not	PART
dti-3495	59	17	only	only	ADV
dti-3495	59	18	effective	effective	ADJ
dti-3495	59	19	but	but	CCONJ
dti-3495	59	20	also	also	ADV
dti-3495	59	21	associated	associate	VERB
dti-3495	59	22	with	with	ADP
dti-3495	59	23	fewer	few	ADJ
dti-3495	59	24	side	side	NOUN
dti-3495	59	25	effects	effect	NOUN
dti-3495	59	26	.	.	PUNCT
dti-3495	60	1	natural	natural	ADJ
dti-3495	60	2	products	product	NOUN
dti-3495	60	3	offer	offer	VERB
dti-3495	60	4	a	a	DET
dti-3495	60	5	cheap	cheap	ADJ
dti-3495	60	6	source	source	NOUN
dti-3495	60	7	for	for	ADP
dti-3495	60	8	new	new	ADJ
dti-3495	60	9	drug	drug	NOUN
dti-3495	60	10	development	development	NOUN
dti-3495	60	11	,	,	PUNCT
dti-3495	60	12	and	and	CCONJ
dti-3495	60	13	they	they	PRON
dti-3495	60	14	can	can	AUX
dti-3495	60	15	be	be	AUX
dti-3495	60	16	used	use	VERB
dti-3495	60	17	to	to	PART
dti-3495	60	18	discover	discover	VERB
dti-3495	60	19	drugs	drug	NOUN
dti-3495	60	20	that	that	PRON
dti-3495	60	21	fight	fight	VERB
dti-3495	60	22	various	various	ADJ
dti-3495	60	23	diseases	disease	NOUN
dti-3495	60	24	,	,	PUNCT
dti-3495	60	25	including	include	VERB
dti-3495	60	26	dm	dm	PROPN
dti-3495	60	27	(	(	PUNCT
dti-3495	60	28	18,19	18,19	NUM
dti-3495	60	29	)	)	PUNCT
dti-3495	60	30	.	.	PUNCT
dti-3495	61	1	the	the	DET
dti-3495	61	2	use	use	NOUN
dti-3495	61	3	of	of	ADP
dti-3495	61	4	v.	v.	ADP
dti-3495	61	5	unguiculata	unguiculata	ADJ
dti-3495	61	6	plant	plant	NOUN
dti-3495	61	7	as	as	ADP
dti-3495	61	8	an	an	DET
dti-3495	61	9	anti	anti	ADJ
dti-3495	61	10	-	-	ADJ
dti-3495	61	11	diabetic	diabetic	ADJ
dti-3495	61	12	has	have	AUX
dti-3495	61	13	been	be	AUX
dti-3495	61	14	reported	report	VERB
dti-3495	61	15	traditionally	traditionally	ADV
dti-3495	61	16	;	;	PUNCT
dti-3495	61	17	thus	thus	ADV
dti-3495	61	18	,	,	PUNCT
dti-3495	61	19	based	base	VERB
dti-3495	61	20	on	on	ADP
dti-3495	61	21	the	the	DET
dti-3495	61	22	previous	previous	ADJ
dti-3495	61	23	reported	report	VERB
dti-3495	61	24	studies	study	NOUN
dti-3495	61	25	,	,	PUNCT
dti-3495	61	26	it	it	PRON
dti-3495	61	27	was	be	AUX
dti-3495	61	28	anticipated	anticipate	VERB
dti-3495	61	29	that	that	SCONJ
dti-3495	61	30	v.	v.	PROPN
dti-3495	61	31	unguiculata	unguiculata	PROPN
dti-3495	61	32	would	would	AUX
dti-3495	61	33	be	be	AUX
dti-3495	61	34	effective	effective	ADJ
dti-3495	61	35	against	against	ADP
dti-3495	61	36	dm	dm	PROPN
dti-3495	61	37	.	.	PROPN
dti-3495	61	38	methodology	methodology	NOUN
dti-3495	61	39	plant	plant	NOUN
dti-3495	61	40	material	material	NOUN
dti-3495	61	41	collection	collection	NOUN
dti-3495	61	42	,	,	PUNCT
dti-3495	61	43	identification	identification	NOUN
dti-3495	61	44	,	,	PUNCT
dti-3495	61	45	and	and	CCONJ
dti-3495	61	46	extraction	extraction	NOUN
dti-3495	61	47	in	in	ADP
dti-3495	61	48	august	august	PROPN
dti-3495	61	49	2022	2022	NUM
dti-3495	61	50	,	,	PUNCT
dti-3495	61	51	a	a	DET
dti-3495	61	52	fresh	fresh	ADJ
dti-3495	61	53	whole	whole	ADJ
dti-3495	61	54	plant	plant	NOUN
dti-3495	61	55	(	(	PUNCT
dti-3495	61	56	14	14	NUM
dti-3495	61	57	kg	kg	NOUN
dti-3495	61	58	)	)	PUNCT
dti-3495	61	59	of	of	ADP
dti-3495	61	60	v.	v.	ADP
dti-3495	61	61	unguiculata	unguiculata	PROPN
dti-3495	61	62	was	be	AUX
dti-3495	61	63	gathered	gather	VERB
dti-3495	61	64	from	from	ADP
dti-3495	61	65	village	village	NOUN
dti-3495	61	66	rustam	rustam	NOUN
dti-3495	61	67	,	,	PUNCT
dti-3495	61	68	district	district	NOUN
dti-3495	61	69	mardan	mardan	PROPN
dti-3495	61	70	,	,	PUNCT
dti-3495	61	71	khyber	khyber	PROPN
dti-3495	61	72	pakhtunkhwa	pakhtunkhwa	PROPN
dti-3495	61	73	,	,	PUNCT
dti-3495	61	74	pakistan	pakistan	PROPN
dti-3495	61	75	.	.	PUNCT
dti-3495	62	1	dr	dr	PROPN
dti-3495	62	2	.	.	PROPN
dti-3495	62	3	mohib	mohib	VERB
dti-3495	62	4	shah	shah	NOUN
dti-3495	62	5	from	from	ADP
dti-3495	62	6	the	the	DET
dti-3495	62	7	department	department	NOUN
dti-3495	62	8	of	of	ADP
dti-3495	62	9	botany	botany	NOUN
dti-3495	62	10	,	,	PUNCT
dti-3495	62	11	awkum	awkum	NOUN
dti-3495	62	12	,	,	PUNCT
dti-3495	62	13	authenticated	authenticate	VERB
dti-3495	62	14	and	and	CCONJ
dti-3495	62	15	identified	identify	VERB
dti-3495	62	16	the	the	DET
dti-3495	62	17	plant	plant	NOUN
dti-3495	62	18	specimen	speciman	NOUN
dti-3495	62	19	by	by	ADP
dti-3495	62	20	comparing	compare	VERB
dti-3495	62	21	it	it	PRON
dti-3495	62	22	with	with	ADP
dti-3495	62	23	existing	exist	VERB
dti-3495	62	24	specimens	specimen	NOUN
dti-3495	62	25	at	at	ADP
dti-3495	62	26	the	the	DET
dti-3495	62	27	department	department	NOUN
dti-3495	62	28	of	of	ADP
dti-3495	62	29	botany	botany	NOUN
dti-3495	62	30	,	,	PUNCT
dti-3495	62	31	awkum	awkum	NOUN
dti-3495	62	32	,	,	PUNCT
dti-3495	62	33	and	and	CCONJ
dti-3495	62	34	the	the	DET
dti-3495	62	35	flora	flora	NOUN
dti-3495	62	36	of	of	ADP
dti-3495	62	37	pakistan	pakistan	PROPN
dti-3495	62	38	.	.	PUNCT
dti-3495	63	1	the	the	DET
dti-3495	63	2	department	department	NOUN
dti-3495	63	3	of	of	ADP
dti-3495	63	4	botany	botany	NOUN
dti-3495	63	5	,	,	PUNCT
dti-3495	63	6	awkum	awkum	NOUN
dti-3495	63	7	,	,	PUNCT
dti-3495	63	8	assigned	assign	VERB
dti-3495	63	9	voucher	voucher	ADJ
dti-3495	63	10	no	no	PROPN
dti-3495	63	11	.	.	PUNCT
dti-3495	63	12	awkum.bot.100.31.3.9	awkum.bot.100.31.3.9	PROPN
dti-3495	63	13	to	to	ADP
dti-3495	63	14	the	the	DET
dti-3495	63	15	plant	plant	NOUN
dti-3495	63	16	specimen	speciman	NOUN
dti-3495	63	17	.	.	PUNCT
dti-3495	64	1	after	after	ADP
dti-3495	64	2	cleaning	clean	VERB
dti-3495	64	3	,	,	PUNCT
dti-3495	64	4	fresh	fresh	ADJ
dti-3495	64	5	plant	plant	NOUN
dti-3495	64	6	material	material	NOUN
dti-3495	64	7	was	be	AUX
dti-3495	64	8	dried	dry	VERB
dti-3495	64	9	in	in	ADP
dti-3495	64	10	the	the	DET
dti-3495	64	11	shade	shade	NOUN
dti-3495	64	12	at	at	ADP
dti-3495	64	13	room	room	NOUN
dti-3495	64	14	temperature	temperature	NOUN
dti-3495	64	15	.	.	PUNCT
dti-3495	65	1	the	the	DET
dti-3495	65	2	entire	entire	ADJ
dti-3495	65	3	dried	dry	VERB
dti-3495	65	4	plant	plant	NOUN
dti-3495	65	5	was	be	AUX
dti-3495	65	6	crushed	crush	VERB
dti-3495	65	7	,	,	PUNCT
dti-3495	65	8	resulting	result	VERB
dti-3495	65	9	in	in	ADP
dti-3495	65	10	838	838	NUM
dti-3495	65	11	gm	gm	PROPN
dti-3495	65	12	of	of	ADP
dti-3495	65	13	powdered	powdered	ADJ
dti-3495	65	14	plant	plant	NOUN
dti-3495	65	15	.	.	PUNCT
dti-3495	66	1	the	the	DET
dti-3495	66	2	powdered	powdered	ADJ
dti-3495	66	3	plant	plant	NOUN
dti-3495	66	4	was	be	AUX
dti-3495	66	5	macerated	macerate	VERB
dti-3495	66	6	using	use	VERB
dti-3495	66	7	a	a	DET
dti-3495	66	8	hydroalcoholic	hydroalcoholic	ADJ
dti-3495	66	9	solvent	solvent	NOUN
dti-3495	66	10	(	(	PUNCT
dti-3495	66	11	90	90	NUM
dti-3495	66	12	%	%	NOUN
dti-3495	66	13	methanol	methanol	NOUN
dti-3495	66	14	and	and	CCONJ
dti-3495	66	15	10	10	NUM
dti-3495	66	16	%	%	NOUN
dti-3495	66	17	distilled	distil	VERB
dti-3495	66	18	water	water	NOUN
dti-3495	66	19	)	)	PUNCT
dti-3495	66	20	following	follow	VERB
dti-3495	66	21	the	the	DET
dti-3495	66	22	procedure	procedure	NOUN
dti-3495	66	23	described	describe	VERB
dti-3495	66	24	by	by	ADP
dti-3495	66	25	mistriyani	mistriyani	PROPN
dti-3495	66	26	et	et	PROPN
dti-3495	66	27	al	al	PROPN
dti-3495	66	28	.	.	PROPN
dti-3495	67	1	(	(	PUNCT
dti-3495	67	2	20	20	NUM
dti-3495	67	3	)	)	PUNCT
dti-3495	67	4	.	.	PUNCT
dti-3495	68	1	the	the	DET
dti-3495	68	2	procedure	procedure	NOUN
dti-3495	68	3	was	be	AUX
dti-3495	68	4	repeated	repeat	VERB
dti-3495	68	5	three	three	NUM
dti-3495	68	6	times	time	NOUN
dti-3495	68	7	to	to	PART
dti-3495	68	8	achieve	achieve	VERB
dti-3495	68	9	the	the	DET
dti-3495	68	10	highest	high	ADJ
dti-3495	68	11	extraction	extraction	NOUN
dti-3495	68	12	possible	possible	ADJ
dti-3495	68	13	.	.	PUNCT
dti-3495	69	1	the	the	DET
dti-3495	69	2	solvent	solvent	NOUN
dti-3495	69	3	was	be	AUX
dti-3495	69	4	evaporated	evaporate	VERB
dti-3495	69	5	using	use	VERB
dti-3495	69	6	a	a	DET
dti-3495	69	7	rotary	rotary	ADJ
dti-3495	69	8	evaporator	evaporator	NOUN
dti-3495	69	9	sardar	sardar	PROPN
dti-3495	69	10	et	et	PROPN
dti-3495	69	11	al	al	PROPN
dti-3495	69	12	drug	drug	PROPN
dti-3495	69	13	target	target	NOUN
dti-3495	69	14	insights	insight	NOUN
dti-3495	69	15	2025	2025	NUM
dti-3495	69	16	;	;	PUNCT
dti-3495	69	17	19	19	NUM
dti-3495	69	18	:	:	SYM
dti-3495	69	19	73	73	NUM
dti-3495	69	20	©	©	PROPN
dti-3495	69	21	2025	2025	NUM
dti-3495	69	22	the	the	DET
dti-3495	69	23	authors	author	NOUN
dti-3495	69	24	.	.	PUNCT
dti-3495	70	1	published	publish	VERB
dti-3495	70	2	by	by	ADP
dti-3495	70	3	aboutscience	aboutscience	NOUN
dti-3495	70	4	www.aboutscience.eu	www.aboutscience.eu	NOUN
dti-3495	70	5	to	to	PART
dti-3495	70	6	concentrate	concentrate	VERB
dti-3495	70	7	the	the	DET
dti-3495	70	8	filtrate	filtrate	NOUN
dti-3495	70	9	.	.	PUNCT
dti-3495	71	1	the	the	DET
dti-3495	71	2	concentrated	concentrated	ADJ
dti-3495	71	3	extract	extract	NOUN
dti-3495	71	4	was	be	AUX
dti-3495	71	5	then	then	ADV
dti-3495	71	6	dried	dry	VERB
dti-3495	71	7	in	in	ADP
dti-3495	71	8	an	an	DET
dti-3495	71	9	oven	oven	NOUN
dti-3495	71	10	at	at	ADP
dti-3495	71	11	approximately	approximately	ADV
dti-3495	71	12	40	40	NUM
dti-3495	71	13	°	°	NOUN
dti-3495	71	14	c	c	NOUN
dti-3495	71	15	.	.	PUNCT
dti-3495	72	1	ultimately	ultimately	ADV
dti-3495	72	2	,	,	PUNCT
dti-3495	72	3	186	186	NUM
dti-3495	72	4	g	g	NOUN
dti-3495	72	5	of	of	ADP
dti-3495	72	6	oily	oily	ADJ
dti-3495	72	7	,	,	PUNCT
dti-3495	72	8	viscous	viscous	ADJ
dti-3495	72	9	extract	extract	NOUN
dti-3495	72	10	was	be	AUX
dti-3495	72	11	acquired	acquire	VERB
dti-3495	72	12	and	and	CCONJ
dti-3495	72	13	stored	store	VERB
dti-3495	72	14	in	in	ADP
dti-3495	72	15	a	a	DET
dti-3495	72	16	refrigerator	refrigerator	NOUN
dti-3495	72	17	at	at	ADP
dti-3495	72	18	2	2	NUM
dti-3495	72	19	-	-	SYM
dti-3495	72	20	8	8	NUM
dti-3495	72	21	°	°	NOUN
dti-3495	72	22	c	c	NOUN
dti-3495	72	23	.	.	PUNCT
dti-3495	73	1	fractionation	fractionation	NOUN
dti-3495	73	2	distilled	distil	VERB
dti-3495	73	3	water	water	NOUN
dti-3495	73	4	at	at	ADP
dti-3495	73	5	a	a	DET
dti-3495	73	6	warm	warm	ADJ
dti-3495	73	7	temperature	temperature	NOUN
dti-3495	73	8	was	be	AUX
dti-3495	73	9	added	add	VERB
dti-3495	73	10	to	to	ADP
dti-3495	73	11	the	the	DET
dti-3495	73	12	hydro	hydro	NOUN
dti-3495	73	13	-	-	PUNCT
dti-3495	73	14	methanolic	methanolic	NOUN
dti-3495	73	15	extract	extract	NOUN
dti-3495	73	16	.	.	PUNCT
dti-3495	74	1	the	the	DET
dti-3495	74	2	mixture	mixture	NOUN
dti-3495	74	3	was	be	AUX
dti-3495	74	4	then	then	ADV
dti-3495	74	5	separated	separate	VERB
dti-3495	74	6	using	use	VERB
dti-3495	74	7	n	n	CCONJ
dti-3495	74	8	-	-	PUNCT
dti-3495	74	9	hexane	hexane	NOUN
dti-3495	74	10	in	in	ADP
dti-3495	74	11	a	a	DET
dti-3495	74	12	separating	separate	VERB
dti-3495	74	13	funnel	funnel	NOUN
dti-3495	74	14	.	.	PUNCT
dti-3495	75	1	the	the	DET
dti-3495	75	2	remaining	remain	VERB
dti-3495	75	3	methanol	methanol	NOUN
dti-3495	75	4	extract	extract	NOUN
dti-3495	75	5	was	be	AUX
dti-3495	75	6	then	then	ADV
dti-3495	75	7	fractionated	fractionate	VERB
dti-3495	75	8	using	use	VERB
dti-3495	75	9	ethyl	ethyl	PROPN
dti-3495	75	10	acetate	acetate	NOUN
dti-3495	75	11	to	to	PART
dti-3495	75	12	yield	yield	VERB
dti-3495	75	13	n	n	CCONJ
dti-3495	75	14	-	-	PUNCT
dti-3495	75	15	hexane	hexane	NOUN
dti-3495	75	16	,	,	PUNCT
dti-3495	75	17	ethyl	ethyl	PROPN
dti-3495	75	18	acetate	acetate	NOUN
dti-3495	75	19	,	,	PUNCT
dti-3495	75	20	and	and	CCONJ
dti-3495	75	21	water	water	NOUN
dti-3495	75	22	fractions	fraction	NOUN
dti-3495	75	23	.	.	PUNCT
dti-3495	76	1	this	this	DET
dti-3495	76	2	process	process	NOUN
dti-3495	76	3	was	be	AUX
dti-3495	76	4	repeated	repeat	VERB
dti-3495	76	5	multiple	multiple	ADJ
dti-3495	76	6	times	time	NOUN
dti-3495	76	7	to	to	PART
dti-3495	76	8	obtain	obtain	VERB
dti-3495	76	9	the	the	DET
dti-3495	76	10	maximum	maximum	ADJ
dti-3495	76	11	fractions	fraction	NOUN
dti-3495	76	12	.	.	PUNCT
dti-3495	77	1	the	the	DET
dti-3495	77	2	fractions	fraction	NOUN
dti-3495	77	3	were	be	AUX
dti-3495	77	4	further	far	ADV
dti-3495	77	5	concentrated	concentrate	VERB
dti-3495	77	6	using	use	VERB
dti-3495	77	7	a	a	DET
dti-3495	77	8	vacuum	vacuum	NOUN
dti-3495	77	9	rotary	rotary	NOUN
dti-3495	77	10	evaporator	evaporator	NOUN
dti-3495	77	11	and	and	CCONJ
dti-3495	77	12	then	then	ADV
dti-3495	77	13	dried	dry	VERB
dti-3495	77	14	in	in	ADP
dti-3495	77	15	an	an	DET
dti-3495	77	16	oven	oven	NOUN
dti-3495	77	17	at	at	ADP
dti-3495	77	18	approximately	approximately	ADV
dti-3495	77	19	40	40	NUM
dti-3495	77	20	°	°	NOUN
dti-3495	77	21	c	c	NOUN
dti-3495	77	22	.	.	PUNCT
dti-3495	78	1	in	in	ADP
dti-3495	78	2	-	-	PUNCT
dti-3495	78	3	vitro	vitro	X
dti-3495	78	4	anti	anti	ADJ
dti-3495	78	5	-	-	ADJ
dti-3495	78	6	diabetic	diabetic	ADJ
dti-3495	78	7	activity	activity	NOUN
dti-3495	78	8	the	the	DET
dti-3495	78	9	in	in	ADV
dti-3495	78	10	vitro	vitro	X
dti-3495	78	11	anti	anti	ADJ
dti-3495	78	12	-	-	ADJ
dti-3495	78	13	diabetic	diabetic	ADJ
dti-3495	78	14	activities	activity	NOUN
dti-3495	78	15	of	of	ADP
dti-3495	78	16	both	both	CCONJ
dti-3495	78	17	the	the	DET
dti-3495	78	18	crude	crude	ADJ
dti-3495	78	19	hydro	hydro	NOUN
dti-3495	78	20	-	-	PUNCT
dti-3495	78	21	methanolic	methanolic	NOUN
dti-3495	78	22	extract	extract	NOUN
dti-3495	78	23	and	and	CCONJ
dti-3495	78	24	the	the	DET
dti-3495	78	25	subsequent	subsequent	ADJ
dti-3495	78	26	fractions	fraction	NOUN
dti-3495	78	27	were	be	AUX
dti-3495	78	28	examined	examine	VERB
dti-3495	78	29	.	.	PUNCT
dti-3495	79	1	α	α	X
dti-3495	79	2	-	-	PUNCT
dti-3495	79	3	amylase	amylase	NOUN
dti-3495	79	4	inhibitory	inhibitory	ADJ
dti-3495	79	5	activity	activity	NOUN
dti-3495	79	6	the	the	DET
dti-3495	79	7	already	already	ADV
dti-3495	79	8	established	establish	VERB
dti-3495	79	9	technique	technique	NOUN
dti-3495	79	10	was	be	AUX
dti-3495	79	11	used	use	VERB
dti-3495	79	12	to	to	PART
dti-3495	79	13	conduct	conduct	VERB
dti-3495	79	14	the	the	DET
dti-3495	79	15	alpha	alpha	NOUN
dti-3495	79	16	amylase	amylase	NOUN
dti-3495	79	17	inhibitory	inhibitory	ADJ
dti-3495	79	18	assay	assay	NOUN
dti-3495	79	19	(	(	PUNCT
dti-3495	79	20	21	21	NUM
dti-3495	79	21	)	)	PUNCT
dti-3495	79	22	.	.	PUNCT
dti-3495	80	1	in	in	ADP
dti-3495	80	2	a	a	DET
dti-3495	80	3	96	96	NUM
dti-3495	80	4	-	-	PUNCT
dti-3495	80	5	well	well	NOUN
dti-3495	80	6	microplate	microplate	NOUN
dti-3495	80	7	,	,	PUNCT
dti-3495	80	8	5	5	NUM
dti-3495	80	9	μl	μl	ADP
dti-3495	80	10	of	of	ADP
dti-3495	80	11	the	the	DET
dti-3495	80	12	enzyme	enzyme	NOUN
dti-3495	80	13	solution	solution	NOUN
dti-3495	80	14	and	and	CCONJ
dti-3495	80	15	15	15	NUM
dti-3495	80	16	μl	μl	NOUN
dti-3495	80	17	of	of	ADP
dti-3495	80	18	sample	sample	NOUN
dti-3495	80	19	,	,	PUNCT
dti-3495	80	20	diluted	dilute	VERB
dti-3495	80	21	in	in	ADP
dti-3495	80	22	phosphate	phosphate	ADJ
dti-3495	80	23	buffer	buffer	NOUN
dti-3495	80	24	at	at	ADP
dti-3495	80	25	various	various	ADJ
dti-3495	80	26	concentrations	concentration	NOUN
dti-3495	80	27	,	,	PUNCT
dti-3495	80	28	were	be	AUX
dti-3495	80	29	added	add	VERB
dti-3495	80	30	.	.	PUNCT
dti-3495	81	1	the	the	DET
dti-3495	81	2	reaction	reaction	NOUN
dti-3495	81	3	was	be	AUX
dti-3495	81	4	initiated	initiate	VERB
dti-3495	81	5	with	with	ADP
dti-3495	81	6	the	the	DET
dti-3495	81	7	addition	addition	NOUN
dti-3495	81	8	of	of	ADP
dti-3495	81	9	20	20	NUM
dti-3495	81	10	μl	μl	NUM
dti-3495	81	11	starch	starch	NOUN
dti-3495	81	12	solution	solution	NOUN
dti-3495	81	13	and	and	CCONJ
dti-3495	81	14	then	then	ADV
dti-3495	81	15	incubated	incubate	VERB
dti-3495	81	16	for	for	ADP
dti-3495	81	17	10	10	NUM
dti-3495	81	18	minutes	minute	NOUN
dti-3495	81	19	at	at	ADP
dti-3495	81	20	37	37	NUM
dti-3495	81	21	°	°	NOUN
dti-3495	81	22	c	c	NOUN
dti-3495	81	23	,	,	PUNCT
dti-3495	81	24	followed	follow	VERB
dti-3495	81	25	by	by	ADP
dti-3495	81	26	further	further	ADJ
dti-3495	81	27	incubation	incubation	NOUN
dti-3495	81	28	at	at	ADP
dti-3495	81	29	37	37	NUM
dti-3495	81	30	°	°	NOUN
dti-3495	81	31	c	c	NOUN
dti-3495	81	32	for	for	ADP
dti-3495	81	33	30	30	NUM
dti-3495	81	34	minutes	minute	NOUN
dti-3495	81	35	.	.	PUNCT
dti-3495	82	1	hcl	hcl	PROPN
dti-3495	82	2	(	(	PUNCT
dti-3495	82	3	10	10	NUM
dti-3495	82	4	μl	μl	ADP
dti-3495	82	5	of	of	ADP
dti-3495	82	6	1	1	NUM
dti-3495	82	7	m	m	NOUN
dti-3495	82	8	)	)	PUNCT
dti-3495	82	9	and	and	CCONJ
dti-3495	82	10	iodine	iodine	VERB
dti-3495	82	11	reagent	reagent	NOUN
dti-3495	82	12	(	(	PUNCT
dti-3495	82	13	75	75	NUM
dti-3495	82	14	μl	μl	PRON
dti-3495	82	15	)	)	PUNCT
dti-3495	82	16	were	be	AUX
dti-3495	82	17	added	add	VERB
dti-3495	82	18	to	to	ADP
dti-3495	82	19	each	each	DET
dti-3495	82	20	well	well	NOUN
dti-3495	82	21	to	to	PART
dti-3495	82	22	stop	stop	VERB
dti-3495	82	23	the	the	DET
dti-3495	82	24	reaction	reaction	NOUN
dti-3495	82	25	.	.	PUNCT
dti-3495	83	1	acarbose	acarbose	PROPN
dti-3495	83	2	at	at	ADP
dti-3495	83	3	a	a	DET
dti-3495	83	4	concentration	concentration	NOUN
dti-3495	83	5	of	of	ADP
dti-3495	83	6	64	64	NUM
dti-3495	83	7	μg	μg	NOUN
dti-3495	83	8	/	/	SYM
dti-3495	83	9	ml	ml	VERB
dti-3495	83	10	served	serve	VERB
dti-3495	83	11	as	as	ADP
dti-3495	83	12	the	the	DET
dti-3495	83	13	positive	positive	ADJ
dti-3495	83	14	control	control	NOUN
dti-3495	83	15	,	,	PUNCT
dti-3495	83	16	and	and	CCONJ
dti-3495	83	17	a	a	DET
dti-3495	83	18	blank	blank	NOUN
dti-3495	83	19	was	be	AUX
dti-3495	83	20	created	create	VERB
dti-3495	83	21	using	use	VERB
dti-3495	83	22	phosphate	phosphate	NOUN
dti-3495	83	23	buffer	buffer	NOUN
dti-3495	83	24	(	(	PUNCT
dti-3495	83	25	ph	ph	NOUN
dti-3495	83	26	6.9	6.9	NUM
dti-3495	83	27	)	)	PUNCT
dti-3495	83	28	.	.	PUNCT
dti-3495	84	1	the	the	DET
dti-3495	84	2	absorbance	absorbance	NOUN
dti-3495	84	3	at	at	ADP
dti-3495	84	4	580	580	NUM
dti-3495	84	5	nm	nm	NOUN
dti-3495	84	6	was	be	AUX
dti-3495	84	7	measured	measure	VERB
dti-3495	84	8	,	,	PUNCT
dti-3495	84	9	and	and	CCONJ
dti-3495	84	10	the	the	DET
dti-3495	84	11	percentage	percentage	NOUN
dti-3495	84	12	inhibitory	inhibitory	ADJ
dti-3495	84	13	activity	activity	NOUN
dti-3495	84	14	was	be	AUX
dti-3495	84	15	calculated	calculate	VERB
dti-3495	84	16	using	use	VERB
dti-3495	84	17	the	the	DET
dti-3495	84	18	provided	provide	VERB
dti-3495	84	19	equation	equation	NOUN
dti-3495	84	20	:	:	PUNCT
dti-3495	84	21	%	%	NOUN
dti-3495	84	22	inhibition	inhibition	NOUN
dti-3495	84	23	=	=	VERB
dti-3495	84	24	abs	ab	NOUN
dti-3495	84	25	of	of	ADP
dti-3495	84	26	control	control	NOUN
dti-3495	84	27	–	–	PUNCT
dti-3495	84	28	abs	ab	NOUN
dti-3495	84	29	of	of	ADP
dti-3495	84	30	sample	sample	NOUN
dti-3495	84	31	/abs	/abs	PUNCT
dti-3495	84	32	of	of	ADP
dti-3495	84	33	control	control	NOUN
dti-3495	84	34	x	x	PUNCT
dti-3495	84	35	100	100	NUM
dti-3495	84	36	α	α	NUM
dti-3495	84	37	-	-	PUNCT
dti-3495	84	38	glucosidase	glucosidase	ADJ
dti-3495	84	39	inhibitory	inhibitory	ADJ
dti-3495	84	40	activity	activity	NOUN
dti-3495	84	41	the	the	DET
dti-3495	84	42	already	already	ADV
dti-3495	84	43	established	establish	VERB
dti-3495	84	44	method	method	NOUN
dti-3495	84	45	for	for	ADP
dti-3495	84	46	measuring	measure	VERB
dti-3495	84	47	alphaglucosidase	alphaglucosidase	NOUN
dti-3495	84	48	inhibitory	inhibitory	ADJ
dti-3495	84	49	activity	activity	NOUN
dti-3495	84	50	was	be	AUX
dti-3495	84	51	used	use	VERB
dti-3495	84	52	(	(	PUNCT
dti-3495	84	53	22	22	NUM
dti-3495	84	54	)	)	PUNCT
dti-3495	84	55	.	.	PUNCT
dti-3495	85	1	test	test	NOUN
dti-3495	85	2	samples	sample	NOUN
dti-3495	85	3	at	at	ADP
dti-3495	85	4	different	different	ADJ
dti-3495	85	5	concentrations	concentration	NOUN
dti-3495	85	6	(	(	PUNCT
dti-3495	85	7	20	20	NUM
dti-3495	85	8	μl	μl	NUM
dti-3495	85	9	)	)	PUNCT
dti-3495	85	10	,	,	PUNCT
dti-3495	85	11	alpha	alpha	NOUN
dti-3495	85	12	-	-	PUNCT
dti-3495	85	13	glucosidase	glucosidase	PROPN
dti-3495	85	14	(	(	PUNCT
dti-3495	85	15	1	1	NUM
dti-3495	85	16	u	u	NOUN
dti-3495	85	17	/	/	SYM
dti-3495	85	18	ml	ml	NOUN
dti-3495	85	19	)	)	PUNCT
dti-3495	85	20	(	(	PUNCT
dti-3495	85	21	10	10	NUM
dti-3495	85	22	μl	μl	NUM
dti-3495	85	23	)	)	PUNCT
dti-3495	85	24	,	,	PUNCT
dti-3495	85	25	and	and	CCONJ
dti-3495	85	26	phosphate	phosphate	ADJ
dti-3495	85	27	buffer	buffer	NOUN
dti-3495	85	28	(	(	PUNCT
dti-3495	85	29	100	100	NUM
dti-3495	85	30	mm	mm	NOUN
dti-3495	85	31	,	,	PUNCT
dti-3495	85	32	ph	ph	NOUN
dti-3495	85	33	=	=	NOUN
dti-3495	85	34	6.8	6.8	NUM
dti-3495	85	35	)	)	PUNCT
dti-3495	85	36	(	(	PUNCT
dti-3495	85	37	50	50	NUM
dti-3495	85	38	μl	μl	PRON
dti-3495	85	39	)	)	PUNCT
dti-3495	85	40	were	be	AUX
dti-3495	85	41	combined	combine	VERB
dti-3495	85	42	and	and	CCONJ
dti-3495	85	43	allowed	allow	VERB
dti-3495	85	44	to	to	PART
dti-3495	85	45	preincubate	preincubate	VERB
dti-3495	85	46	for	for	ADP
dti-3495	85	47	15	15	NUM
dti-3495	85	48	minutes	minute	NOUN
dti-3495	85	49	at	at	ADP
dti-3495	85	50	37	37	NUM
dti-3495	85	51	°	°	ADP
dti-3495	85	52	c	c	NOUN
dti-3495	85	53	in	in	ADP
dti-3495	85	54	a	a	DET
dti-3495	85	55	96	96	NUM
dti-3495	85	56	-	-	PUNCT
dti-3495	85	57	well	well	NOUN
dti-3495	85	58	microplate	microplate	NOUN
dti-3495	85	59	.	.	PUNCT
dti-3495	86	1	following	follow	VERB
dti-3495	86	2	the	the	DET
dti-3495	86	3	addition	addition	NOUN
dti-3495	86	4	of	of	ADP
dti-3495	86	5	p	p	NOUN
dti-3495	86	6	-	-	PUNCT
dti-3495	86	7	nitrophenyl	nitrophenyl	NOUN
dti-3495	86	8	glucopyranoside	glucopyranoside	NOUN
dti-3495	86	9	(	(	PUNCT
dti-3495	86	10	5	5	NUM
dti-3495	86	11	mm	mm	NOUN
dti-3495	86	12	)	)	PUNCT
dti-3495	86	13	as	as	ADP
dti-3495	86	14	the	the	DET
dti-3495	86	15	substrate	substrate	NOUN
dti-3495	86	16	(	(	PUNCT
dti-3495	86	17	20	20	NUM
dti-3495	86	18	μl	μl	NUM
dti-3495	86	19	)	)	PUNCT
dti-3495	86	20	,	,	PUNCT
dti-3495	86	21	the	the	DET
dti-3495	86	22	mixture	mixture	NOUN
dti-3495	86	23	was	be	AUX
dti-3495	86	24	incubated	incubate	VERB
dti-3495	86	25	for	for	ADP
dti-3495	86	26	20	20	NUM
dti-3495	86	27	minutes	minute	NOUN
dti-3495	86	28	at	at	ADP
dti-3495	86	29	37	37	NUM
dti-3495	86	30	°	°	NOUN
dti-3495	86	31	c	c	NOUN
dti-3495	86	32	.	.	PUNCT
dti-3495	87	1	the	the	DET
dti-3495	87	2	reaction	reaction	NOUN
dti-3495	87	3	was	be	AUX
dti-3495	87	4	stopped	stop	VERB
dti-3495	87	5	by	by	ADP
dti-3495	87	6	adding	add	VERB
dti-3495	87	7	50	50	NUM
dti-3495	87	8	μl	μl	ADP
dti-3495	87	9	of	of	ADP
dti-3495	87	10	0.1	0.1	NUM
dti-3495	87	11	m	m	NOUN
dti-3495	87	12	sodium	sodium	NOUN
dti-3495	87	13	carbonate	carbonate	NOUN
dti-3495	87	14	(	(	PUNCT
dti-3495	87	15	na2co3	na2co3	PROPN
dti-3495	87	16	)	)	PUNCT
dti-3495	87	17	.	.	PUNCT
dti-3495	88	1	the	the	DET
dti-3495	88	2	absorbance	absorbance	NOUN
dti-3495	88	3	of	of	ADP
dti-3495	88	4	the	the	DET
dti-3495	88	5	liberated	liberated	ADJ
dti-3495	88	6	p	p	NOUN
dti-3495	88	7	-	-	PUNCT
dti-3495	88	8	nitrophenol	nitrophenol	NOUN
dti-3495	88	9	was	be	AUX
dti-3495	88	10	determined	determine	VERB
dti-3495	88	11	at	at	ADP
dti-3495	88	12	405	405	NUM
dti-3495	88	13	nm	nm	NOUN
dti-3495	88	14	using	use	VERB
dti-3495	88	15	a	a	DET
dti-3495	88	16	microplate	microplate	NOUN
dti-3495	88	17	reader	reader	NOUN
dti-3495	88	18	.	.	PUNCT
dti-3495	89	1	acarbose	acarbose	PROPN
dti-3495	89	2	was	be	AUX
dti-3495	89	3	utilized	utilize	VERB
dti-3495	89	4	as	as	ADP
dti-3495	89	5	a	a	DET
dti-3495	89	6	standard	standard	NOUN
dti-3495	89	7	in	in	ADP
dti-3495	89	8	different	different	ADJ
dti-3495	89	9	concentrations	concentration	NOUN
dti-3495	89	10	.	.	PUNCT
dti-3495	90	1	each	each	DET
dti-3495	90	2	experiment	experiment	NOUN
dti-3495	90	3	was	be	AUX
dti-3495	90	4	conducted	conduct	VERB
dti-3495	90	5	in	in	ADP
dti-3495	90	6	triplicate	triplicate	NOUN
dti-3495	90	7	,	,	PUNCT
dti-3495	90	8	with	with	ADP
dti-3495	90	9	a	a	DET
dti-3495	90	10	parallel	parallel	ADJ
dti-3495	90	11	setup	setup	NOUN
dti-3495	90	12	that	that	PRON
dti-3495	90	13	did	do	AUX
dti-3495	90	14	not	not	PART
dti-3495	90	15	contain	contain	VERB
dti-3495	90	16	any	any	DET
dti-3495	90	17	test	test	NOUN
dti-3495	90	18	sample	sample	NOUN
dti-3495	90	19	.	.	PUNCT
dti-3495	91	1	the	the	DET
dti-3495	91	2	%	%	NOUN
dti-3495	91	3	inhibitory	inhibitory	ADJ
dti-3495	91	4	activity	activity	NOUN
dti-3495	91	5	was	be	AUX
dti-3495	91	6	calculated	calculate	VERB
dti-3495	91	7	using	use	VERB
dti-3495	91	8	the	the	DET
dti-3495	91	9	provided	provide	VERB
dti-3495	91	10	equation	equation	NOUN
dti-3495	91	11	:	:	PUNCT
dti-3495	91	12	%	%	NOUN
dti-3495	91	13	inhibition	inhibition	NOUN
dti-3495	91	14	=	=	VERB
dti-3495	91	15	absorbance	absorbance	NOUN
dti-3495	91	16	of	of	ADP
dti-3495	91	17	control	control	NOUN
dti-3495	91	18	–	–	PUNCT
dti-3495	91	19	absorbance	absorbance	NOUN
dti-3495	91	20	of	of	ADP
dti-3495	91	21	sample	sample	NOUN
dti-3495	91	22	/absorbance	/absorbance	NOUN
dti-3495	91	23	of	of	ADP
dti-3495	91	24	control	control	NOUN
dti-3495	91	25	x	x	SYM
dti-3495	91	26	100	100	NUM
dti-3495	91	27	aldose	aldose	PRON
dti-3495	91	28	reductase	reductase	NOUN
dti-3495	91	29	inhibitory	inhibitory	NOUN
dti-3495	91	30	assay	assay	VERB
dti-3495	91	31	the	the	DET
dti-3495	91	32	evaluation	evaluation	NOUN
dti-3495	91	33	of	of	ADP
dti-3495	91	34	aldose	aldose	PRON
dti-3495	91	35	reductase	reductase	NOUN
dti-3495	91	36	inhibitory	inhibitory	ADJ
dti-3495	91	37	activity	activity	NOUN
dti-3495	91	38	was	be	AUX
dti-3495	91	39	conducted	conduct	VERB
dti-3495	91	40	using	use	VERB
dti-3495	91	41	a	a	DET
dti-3495	91	42	previously	previously	ADV
dti-3495	91	43	established	establish	VERB
dti-3495	91	44	method	method	NOUN
dti-3495	91	45	(	(	PUNCT
dti-3495	91	46	23	23	NUM
dti-3495	91	47	)	)	PUNCT
dti-3495	91	48	with	with	ADP
dti-3495	91	49	some	some	DET
dti-3495	91	50	modifications	modification	NOUN
dti-3495	91	51	.	.	PUNCT
dti-3495	92	1	upon	upon	SCONJ
dti-3495	92	2	euthanasia	euthanasia	NOUN
dti-3495	92	3	,	,	PUNCT
dti-3495	92	4	the	the	DET
dti-3495	92	5	eyes	eye	NOUN
dti-3495	92	6	of	of	ADP
dti-3495	92	7	normal	normal	ADJ
dti-3495	92	8	swiss	swiss	ADJ
dti-3495	92	9	albino	albino	NOUN
dti-3495	92	10	mice	mouse	NOUN
dti-3495	92	11	were	be	AUX
dti-3495	92	12	promptly	promptly	ADV
dti-3495	92	13	extracted	extract	VERB
dti-3495	92	14	,	,	PUNCT
dti-3495	92	15	and	and	CCONJ
dti-3495	92	16	the	the	DET
dti-3495	92	17	lenses	lense	NOUN
dti-3495	92	18	were	be	AUX
dti-3495	92	19	subsequently	subsequently	ADV
dti-3495	92	20	cleansed	cleanse	VERB
dti-3495	92	21	with	with	ADP
dti-3495	92	22	normal	normal	ADJ
dti-3495	92	23	saline	saline	NOUN
dti-3495	92	24	.	.	PUNCT
dti-3495	93	1	the	the	DET
dti-3495	93	2	weights	weight	NOUN
dti-3495	93	3	of	of	ADP
dti-3495	93	4	the	the	DET
dti-3495	93	5	lenses	lense	NOUN
dti-3495	93	6	were	be	AUX
dti-3495	93	7	then	then	ADV
dti-3495	93	8	re	re	VERB
dti-3495	93	9	-	-	VERB
dti-3495	93	10	determined	determined	ADJ
dti-3495	93	11	.	.	PUNCT
dti-3495	94	1	once	once	ADV
dti-3495	94	2	transparent	transparent	ADJ
dti-3495	94	3	lenses	lense	NOUN
dti-3495	94	4	were	be	AUX
dti-3495	94	5	obtained	obtain	VERB
dti-3495	94	6	,	,	PUNCT
dti-3495	94	7	a	a	DET
dti-3495	94	8	10	10	NUM
dti-3495	94	9	%	%	NOUN
dti-3495	94	10	homogeneous	homogeneous	ADJ
dti-3495	94	11	solution	solution	NOUN
dti-3495	94	12	was	be	AUX
dti-3495	94	13	prepared	prepare	VERB
dti-3495	94	14	in	in	ADP
dti-3495	94	15	0.1	0.1	NUM
dti-3495	94	16	m	m	NOUN
dti-3495	94	17	phosphate	phosphate	NOUN
dti-3495	94	18	buffer	buffer	NOUN
dti-3495	94	19	saline	saline	NOUN
dti-3495	94	20	(	(	PUNCT
dti-3495	94	21	ph	ph	NOUN
dti-3495	94	22	7.4	7.4	NUM
dti-3495	94	23	)	)	PUNCT
dti-3495	94	24	.	.	PUNCT
dti-3495	95	1	this	this	DET
dti-3495	95	2	solution	solution	NOUN
dti-3495	95	3	was	be	AUX
dti-3495	95	4	then	then	ADV
dti-3495	95	5	subjected	subject	VERB
dti-3495	95	6	to	to	ADP
dti-3495	95	7	centrifugation	centrifugation	NOUN
dti-3495	95	8	at	at	ADP
dti-3495	95	9	5000	5000	NUM
dti-3495	95	10	×	×	NOUN
dti-3495	95	11	g	g	NOUN
dti-3495	95	12	for	for	ADP
dti-3495	95	13	10	10	NUM
dti-3495	95	14	minutes	minute	NOUN
dti-3495	95	15	.	.	PUNCT
dti-3495	96	1	the	the	DET
dti-3495	96	2	resulting	result	VERB
dti-3495	96	3	supernatant	supernatant	NOUN
dti-3495	96	4	was	be	AUX
dti-3495	96	5	collected	collect	VERB
dti-3495	96	6	and	and	CCONJ
dti-3495	96	7	stored	store	VERB
dti-3495	96	8	on	on	ADP
dti-3495	96	9	ice	ice	NOUN
dti-3495	96	10	.	.	PUNCT
dti-3495	97	1	the	the	DET
dti-3495	97	2	protein	protein	NOUN
dti-3495	97	3	content	content	NOUN
dti-3495	97	4	of	of	ADP
dti-3495	97	5	the	the	DET
dti-3495	97	6	lens	lens	NOUN
dti-3495	97	7	homogenate	homogenate	NOUN
dti-3495	97	8	was	be	AUX
dti-3495	97	9	determined	determine	VERB
dti-3495	97	10	.	.	PUNCT
dti-3495	98	1	a	a	DET
dti-3495	98	2	sample	sample	NOUN
dti-3495	98	3	cuvette	cuvette	NOUN
dti-3495	98	4	containing	contain	VERB
dti-3495	98	5	0.7	0.7	NUM
dti-3495	98	6	ml	ml	NOUN
dti-3495	98	7	of	of	ADP
dti-3495	98	8	phosphate	phosphate	ADJ
dti-3495	98	9	buffer	buffer	NOUN
dti-3495	98	10	,	,	PUNCT
dti-3495	98	11	0.1	0.1	NUM
dti-3495	98	12	ml	ml	NOUN
dti-3495	98	13	of	of	ADP
dti-3495	98	14	nadph	nadph	ADJ
dti-3495	98	15	(	(	PUNCT
dti-3495	98	16	25	25	NUM
dti-3495	98	17	×	×	NOUN
dti-3495	98	18	10−5	10−5	NUM
dti-3495	98	19	m	m	NOUN
dti-3495	98	20	)	)	PUNCT
dti-3495	98	21	,	,	PUNCT
dti-3495	98	22	0.1	0.1	NUM
dti-3495	98	23	ml	ml	NOUN
dti-3495	98	24	of	of	ADP
dti-3495	98	25	lens	lens	NOUN
dti-3495	98	26	supernatant	supernatant	NOUN
dti-3495	98	27	,	,	PUNCT
dti-3495	98	28	and	and	CCONJ
dti-3495	98	29	0.1	0.1	NUM
dti-3495	98	30	ml	ml	NOUN
dti-3495	98	31	of	of	ADP
dti-3495	98	32	dl	dl	PROPN
dti-3495	98	33	-	-	PUNCT
dti-3495	98	34	glyceraldehyde	glyceraldehyde	NOUN
dti-3495	98	35	(	(	PUNCT
dti-3495	98	36	5	5	NUM
dti-3495	98	37	×	×	NOUN
dti-3495	98	38	10−4	10−4	NUM
dti-3495	98	39	m	m	NOUN
dti-3495	98	40	)	)	PUNCT
dti-3495	98	41	was	be	AUX
dti-3495	98	42	utilized	utilize	VERB
dti-3495	98	43	to	to	PART
dti-3495	98	44	assess	assess	VERB
dti-3495	98	45	the	the	DET
dti-3495	98	46	aldose	aldose	ADJ
dti-3495	98	47	reductase	reductase	NOUN
dti-3495	98	48	inhibitory	inhibitory	ADJ
dti-3495	98	49	activity	activity	NOUN
dti-3495	98	50	of	of	ADP
dti-3495	98	51	the	the	DET
dti-3495	98	52	fractions	fraction	NOUN
dti-3495	98	53	,	,	PUNCT
dti-3495	98	54	with	with	SCONJ
dti-3495	98	55	a	a	DET
dti-3495	98	56	final	final	ADJ
dti-3495	98	57	volume	volume	NOUN
dti-3495	98	58	of	of	ADP
dti-3495	98	59	1	1	NUM
dti-3495	98	60	ml	ml	NOUN
dti-3495	98	61	.	.	PUNCT
dti-3495	98	62	absorbance	absorbance	NOUN
dti-3495	98	63	measurements	measurement	NOUN
dti-3495	98	64	were	be	AUX
dti-3495	98	65	taken	take	VERB
dti-3495	98	66	in	in	ADP
dti-3495	98	67	comparison	comparison	NOUN
dti-3495	98	68	to	to	ADP
dti-3495	98	69	a	a	DET
dti-3495	98	70	reference	reference	NOUN
dti-3495	98	71	cuvette	cuvette	NOUN
dti-3495	98	72	devoid	devoid	ADJ
dti-3495	98	73	of	of	ADP
dti-3495	98	74	dl	dl	PROPN
dti-3495	98	75	-	-	PUNCT
dti-3495	98	76	glyceraldehyde	glyceraldehyde	NOUN
dti-3495	98	77	.	.	PUNCT
dti-3495	99	1	the	the	DET
dti-3495	99	2	ph	ph	NOUN
dti-3495	99	3	of	of	ADP
dti-3495	99	4	the	the	DET
dti-3495	99	5	reaction	reaction	NOUN
dti-3495	99	6	mixture	mixture	NOUN
dti-3495	99	7	was	be	AUX
dti-3495	99	8	adjusted	adjust	VERB
dti-3495	99	9	to	to	ADP
dti-3495	99	10	6.2	6.2	NUM
dti-3495	99	11	,	,	PUNCT
dti-3495	99	12	and	and	CCONJ
dti-3495	99	13	the	the	DET
dti-3495	99	14	enzymatic	enzymatic	ADJ
dti-3495	99	15	reaction	reaction	NOUN
dti-3495	99	16	was	be	AUX
dti-3495	99	17	initiated	initiate	VERB
dti-3495	99	18	upon	upon	SCONJ
dti-3495	99	19	mixing	mix	VERB
dti-3495	99	20	the	the	DET
dti-3495	99	21	substrate	substrate	NOUN
dti-3495	99	22	with	with	ADP
dti-3495	99	23	the	the	DET
dti-3495	99	24	solution	solution	NOUN
dti-3495	99	25	mixture	mixture	NOUN
dti-3495	99	26	.	.	PUNCT
dti-3495	100	1	the	the	DET
dti-3495	100	2	absorbance	absorbance	NOUN
dti-3495	100	3	was	be	AUX
dti-3495	100	4	then	then	ADV
dti-3495	100	5	monitored	monitor	VERB
dti-3495	100	6	at	at	ADP
dti-3495	100	7	340	340	NUM
dti-3495	100	8	nm	nm	NOUN
dti-3495	100	9	for	for	ADP
dti-3495	100	10	three	three	NUM
dti-3495	100	11	minutes	minute	NOUN
dti-3495	100	12	at	at	ADP
dti-3495	100	13	30	30	NUM
dti-3495	100	14	-	-	PUNCT
dti-3495	100	15	second	second	NOUN
dti-3495	100	16	intervals	interval	NOUN
dti-3495	100	17	.	.	PUNCT
dti-3495	101	1	the	the	DET
dti-3495	101	2	extract	extract	NOUN
dti-3495	101	3	was	be	AUX
dti-3495	101	4	dissolved	dissolve	VERB
dti-3495	101	5	in	in	ADP
dti-3495	101	6	phosphate	phosphate	ADJ
dti-3495	101	7	buffer	buffer	NOUN
dti-3495	101	8	saline	saline	NOUN
dti-3495	101	9	(	(	PUNCT
dti-3495	101	10	pbs	pbs	PROPN
dti-3495	101	11	)	)	PUNCT
dti-3495	101	12	to	to	PART
dti-3495	101	13	produce	produce	VERB
dti-3495	101	14	a	a	DET
dti-3495	101	15	stock	stock	NOUN
dti-3495	101	16	solution	solution	NOUN
dti-3495	101	17	containing	contain	VERB
dti-3495	101	18	all	all	DET
dti-3495	101	19	the	the	DET
dti-3495	101	20	fractions	fraction	NOUN
dti-3495	101	21	.	.	PUNCT
dti-3495	102	1	cuvettes	cuvette	NOUN
dti-3495	102	2	treated	treat	VERB
dti-3495	102	3	with	with	ADP
dti-3495	102	4	0.1	0.1	NUM
dti-3495	102	5	ml	ml	NOUN
dti-3495	102	6	of	of	ADP
dti-3495	102	7	each	each	DET
dti-3495	102	8	fraction	fraction	NOUN
dti-3495	102	9	from	from	ADP
dti-3495	102	10	various	various	ADJ
dti-3495	102	11	stock	stock	NOUN
dti-3495	102	12	solutions	solution	NOUN
dti-3495	102	13	,	,	PUNCT
dti-3495	102	14	with	with	ADP
dti-3495	102	15	final	final	ADJ
dti-3495	102	16	concentrations	concentration	NOUN
dti-3495	102	17	of	of	ADP
dti-3495	102	18	10	10	NUM
dti-3495	102	19	,	,	PUNCT
dti-3495	102	20	25	25	NUM
dti-3495	102	21	,	,	PUNCT
dti-3495	102	22	50	50	NUM
dti-3495	102	23	,	,	PUNCT
dti-3495	102	24	100	100	NUM
dti-3495	102	25	,	,	PUNCT
dti-3495	102	26	200	200	NUM
dti-3495	102	27	,	,	PUNCT
dti-3495	102	28	and	and	CCONJ
dti-3495	102	29	300	300	NUM
dti-3495	102	30	µg	µg	NOUN
dti-3495	102	31	/	/	SYM
dti-3495	102	32	ml	ml	NOUN
dti-3495	102	33	,	,	PUNCT
dti-3495	102	34	were	be	AUX
dti-3495	102	35	used	use	VERB
dti-3495	102	36	as	as	ADP
dti-3495	102	37	reference	reference	NOUN
dti-3495	102	38	and	and	CCONJ
dti-3495	102	39	standard	standard	NOUN
dti-3495	102	40	cuvettes	cuvette	VERB
dti-3495	102	41	to	to	PART
dti-3495	102	42	evaluate	evaluate	VERB
dti-3495	102	43	aldose	aldose	DET
dti-3495	102	44	reductase	reductase	NOUN
dti-3495	102	45	inhibitory	inhibitory	ADJ
dti-3495	102	46	activity	activity	NOUN
dti-3495	102	47	.	.	PUNCT
dti-3495	103	1	the	the	DET
dti-3495	103	2	process	process	NOUN
dti-3495	103	3	was	be	AUX
dti-3495	103	4	initiated	initiate	VERB
dti-3495	103	5	by	by	ADP
dti-3495	103	6	adding	add	VERB
dti-3495	103	7	0.1	0.1	NUM
dti-3495	103	8	ml	ml	NOUN
dti-3495	103	9	of	of	ADP
dti-3495	103	10	dl	dl	NOUN
dti-3495	103	11	-	-	PUNCT
dti-3495	103	12	glyceraldehyde	glyceraldehyde	NOUN
dti-3495	103	13	.	.	PUNCT
dti-3495	104	1	the	the	DET
dti-3495	104	2	percentage	percentage	NOUN
dti-3495	104	3	inhibitions	inhibition	NOUN
dti-3495	104	4	of	of	ADP
dti-3495	104	5	the	the	DET
dti-3495	104	6	aldose	aldose	ADJ
dti-3495	104	7	reductase	reductase	NOUN
dti-3495	104	8	assay	assay	VERB
dti-3495	104	9	for	for	ADP
dti-3495	104	10	the	the	DET
dti-3495	104	11	extract	extract	NOUN
dti-3495	104	12	were	be	AUX
dti-3495	104	13	calculated	calculate	VERB
dti-3495	104	14	assuming	assume	VERB
dti-3495	104	15	that	that	SCONJ
dti-3495	104	16	the	the	DET
dti-3495	104	17	lens	lens	NOUN
dti-3495	104	18	of	of	ADP
dti-3495	104	19	a	a	DET
dti-3495	104	20	normal	normal	ADJ
dti-3495	104	21	mouse	mouse	NOUN
dti-3495	104	22	exhibited	exhibit	VERB
dti-3495	104	23	100	100	NUM
dti-3495	104	24	%	%	NOUN
dti-3495	104	25	activity	activity	NOUN
dti-3495	104	26	.	.	PUNCT
dti-3495	105	1	ic50	ic50	PROPN
dti-3495	105	2	values	value	NOUN
dti-3495	105	3	were	be	AUX
dti-3495	105	4	calculated	calculate	VERB
dti-3495	105	5	for	for	ADP
dti-3495	105	6	each	each	DET
dti-3495	105	7	sample	sample	NOUN
dti-3495	105	8	.	.	PUNCT
dti-3495	106	1	phytocompounds	phytocompound	NOUN
dti-3495	106	2	screening	screen	VERB
dti-3495	106	3	active	active	ADJ
dti-3495	106	4	compounds	compound	NOUN
dti-3495	106	5	of	of	ADP
dti-3495	106	6	v.	v.	ADP
dti-3495	106	7	unguiculata	unguiculata	PROPN
dti-3495	106	8	were	be	AUX
dti-3495	106	9	identified	identify	VERB
dti-3495	106	10	from	from	ADP
dti-3495	106	11	existing	exist	VERB
dti-3495	106	12	literature	literature	NOUN
dti-3495	106	13	and	and	CCONJ
dti-3495	106	14	several	several	ADJ
dti-3495	106	15	databases	database	NOUN
dti-3495	106	16	of	of	ADP
dti-3495	106	17	biologically	biologically	ADV
dti-3495	106	18	active	active	ADJ
dti-3495	106	19	phytochemicals	phytochemical	NOUN
dti-3495	106	20	,	,	PUNCT
dti-3495	106	21	including	include	VERB
dti-3495	106	22	indian	indian	ADJ
dti-3495	106	23	medicinal	medicinal	ADJ
dti-3495	106	24	plants	plant	NOUN
dti-3495	106	25	,	,	PUNCT
dti-3495	106	26	phytochemistry	phytochemistry	NOUN
dti-3495	106	27	,	,	PUNCT
dti-3495	106	28	and	and	CCONJ
dti-3495	106	29	therapeutics	therapeutic	NOUN
dti-3495	106	30	(	(	PUNCT
dti-3495	106	31	imppat	imppat	PROPN
dti-3495	106	32	)	)	PUNCT
dti-3495	106	33	(	(	PUNCT
dti-3495	106	34	24	24	NUM
dti-3495	106	35	)	)	PUNCT
dti-3495	106	36	,	,	PUNCT
dti-3495	106	37	knapsack	knapsack	NOUN
dti-3495	106	38	(	(	PUNCT
dti-3495	106	39	25	25	NUM
dti-3495	106	40	)	)	PUNCT
dti-3495	106	41	.	.	PUNCT
dti-3495	107	1	the	the	DET
dti-3495	107	2	keyword	keyword	NOUN
dti-3495	107	3	’	'	PUNCT
dti-3495	107	4	vigna	vigna	PROPN
dti-3495	107	5	unguiculata	unguiculata	PROPN
dti-3495	107	6	’	'	PUNCT
dti-3495	107	7	was	be	AUX
dti-3495	107	8	used	use	VERB
dti-3495	107	9	for	for	ADP
dti-3495	107	10	database	database	NOUN
dti-3495	107	11	searches	search	NOUN
dti-3495	107	12	,	,	PUNCT
dti-3495	107	13	while	while	SCONJ
dti-3495	107	14	a	a	DET
dti-3495	107	15	comprehensive	comprehensive	ADJ
dti-3495	107	16	literature	literature	NOUN
dti-3495	107	17	review	review	NOUN
dti-3495	107	18	was	be	AUX
dti-3495	107	19	conducted	conduct	VERB
dti-3495	107	20	using	use	VERB
dti-3495	107	21	pubmed	pubmed	PROPN
dti-3495	107	22	and	and	CCONJ
dti-3495	107	23	google	google	PROPN
dti-3495	107	24	scholar	scholar	NOUN
dti-3495	107	25	.	.	PUNCT
dti-3495	108	1	the	the	DET
dti-3495	108	2	bioavailability	bioavailability	NOUN
dti-3495	108	3	(	(	PUNCT
dti-3495	108	4	f	f	X
dti-3495	108	5	)	)	PUNCT
dti-3495	108	6	and	and	CCONJ
dti-3495	108	7	drug	drug	NOUN
dti-3495	108	8	-	-	PUNCT
dti-3495	108	9	likeness	likeness	NOUN
dti-3495	108	10	(	(	PUNCT
dti-3495	108	11	dl	dl	NOUN
dti-3495	108	12	)	)	PUNCT
dti-3495	108	13	of	of	ADP
dti-3495	108	14	all	all	DET
dti-3495	108	15	ingredients	ingredient	NOUN
dti-3495	108	16	were	be	AUX
dti-3495	108	17	assessed	assess	VERB
dti-3495	108	18	to	to	PART
dti-3495	108	19	determine	determine	VERB
dti-3495	108	20	their	their	PRON
dti-3495	108	21	adme	adme	NOUN
dti-3495	108	22	(	(	PUNCT
dti-3495	108	23	absorption	absorption	NOUN
dti-3495	108	24	,	,	PUNCT
dti-3495	108	25	distribution	distribution	NOUN
dti-3495	108	26	,	,	PUNCT
dti-3495	108	27	metabolism	metabolism	NOUN
dti-3495	108	28	,	,	PUNCT
dti-3495	108	29	and	and	CCONJ
dti-3495	108	30	excretion	excretion	NOUN
dti-3495	108	31	)	)	PUNCT
dti-3495	108	32	properties	property	NOUN
dti-3495	108	33	.	.	PUNCT
dti-3495	109	1	compounds	compound	NOUN
dti-3495	109	2	were	be	AUX
dti-3495	109	3	selected	select	VERB
dti-3495	109	4	based	base	VERB
dti-3495	109	5	on	on	ADP
dti-3495	109	6	a	a	DET
dti-3495	109	7	dl	dl	PROPN
dti-3495	109	8	value	value	NOUN
dti-3495	109	9	of	of	ADP
dti-3495	109	10	at	at	ADV
dti-3495	109	11	least	least	ADV
dti-3495	109	12	0.18	0.18	NUM
dti-3495	109	13	and	and	CCONJ
dti-3495	109	14	an	an	DET
dti-3495	109	15	ob	ob	ADJ
dti-3495	109	16	value	value	NOUN
dti-3495	109	17	of	of	ADP
dti-3495	109	18	at	at	ADV
dti-3495	109	19	least	least	ADV
dti-3495	109	20	30	30	NUM
dti-3495	109	21	%	%	NOUN
dti-3495	109	22	.	.	PUNCT
dti-3495	110	1	the	the	DET
dti-3495	110	2	ob	ob	NOUN
dti-3495	110	3	and	and	CCONJ
dti-3495	110	4	dl	dl	PROPN
dti-3495	110	5	values	value	NOUN
dti-3495	110	6	for	for	ADP
dti-3495	110	7	all	all	DET
dti-3495	110	8	active	active	ADJ
dti-3495	110	9	compounds	compound	NOUN
dti-3495	110	10	were	be	AUX
dti-3495	110	11	calculated	calculate	VERB
dti-3495	110	12	using	use	VERB
dti-3495	110	13	swissadme	swissadme	NOUN
dti-3495	110	14	and	and	CCONJ
dti-3495	110	15	admetlab	admetlab	NOUN
dti-3495	110	16	.	.	PUNCT
dti-3495	111	1	additionally	additionally	ADV
dti-3495	111	2	,	,	PUNCT
dti-3495	111	3	chemical	chemical	ADJ
dti-3495	111	4	information	information	NOUN
dti-3495	111	5	such	such	ADJ
dti-3495	111	6	as	as	ADP
dti-3495	111	7	cid	cid	NOUN
dti-3495	111	8	number	number	NOUN
dti-3495	111	9	,	,	PUNCT
dti-3495	111	10	structure	structure	NOUN
dti-3495	111	11	,	,	PUNCT
dti-3495	111	12	and	and	CCONJ
dti-3495	111	13	molecular	molecular	ADJ
dti-3495	111	14	weight	weight	NOUN
dti-3495	111	15	was	be	AUX
dti-3495	111	16	collected	collect	VERB
dti-3495	111	17	from	from	ADP
dti-3495	111	18	pubchem	pubchem	NOUN
dti-3495	111	19	and	and	CCONJ
dti-3495	111	20	chemspider	chemspider	NOUN
dti-3495	111	21	.	.	PUNCT
dti-3495	112	1	retrieval	retrieval	NOUN
dti-3495	112	2	of	of	ADP
dti-3495	112	3	potential	potential	ADJ
dti-3495	112	4	targets	target	NOUN
dti-3495	112	5	of	of	ADP
dti-3495	112	6	selected	select	VERB
dti-3495	112	7	compounds	compound	NOUN
dti-3495	112	8	swiss	swiss	ADJ
dti-3495	112	9	target	target	NOUN
dti-3495	112	10	prediction	prediction	NOUN
dti-3495	112	11	(	(	PUNCT
dti-3495	112	12	26	26	NUM
dti-3495	112	13	)	)	PUNCT
dti-3495	112	14	and	and	CCONJ
dti-3495	112	15	the	the	DET
dti-3495	112	16	stitch	stitch	ADJ
dti-3495	112	17	database	database	NOUN
dti-3495	112	18	(	(	PUNCT
dti-3495	112	19	27	27	NUM
dti-3495	112	20	)	)	PUNCT
dti-3495	112	21	were	be	AUX
dti-3495	112	22	used	use	VERB
dti-3495	112	23	to	to	PART
dti-3495	112	24	predict	predict	VERB
dti-3495	112	25	the	the	DET
dti-3495	112	26	potential	potential	ADJ
dti-3495	112	27	targets	target	NOUN
dti-3495	112	28	of	of	ADP
dti-3495	112	29	selected	select	VERB
dti-3495	112	30	compounds	compound	NOUN
dti-3495	112	31	.	.	PUNCT
dti-3495	113	1	these	these	DET
dti-3495	113	2	compounds	compound	NOUN
dti-3495	113	3	were	be	AUX
dti-3495	113	4	uploaded	upload	VERB
dti-3495	113	5	to	to	ADP
dti-3495	113	6	the	the	DET
dti-3495	113	7	stitch	stitch	ADJ
dti-3495	113	8	database	database	NOUN
dti-3495	113	9	with	with	ADP
dti-3495	113	10	the	the	DET
dti-3495	113	11	options	option	NOUN
dti-3495	113	12	set	set	VERB
dti-3495	113	13	to	to	ADP
dti-3495	113	14	‘	'	PUNCT
dti-3495	113	15	homo	homo	NOUN
dti-3495	113	16	sapiens	sapien	VERB
dti-3495	113	17	’	'	PUNCT
dti-3495	113	18	and	and	CCONJ
dti-3495	113	19	using	use	VERB
dti-3495	113	20	screening	screening	NOUN
dti-3495	113	21	criteria	criterion	NOUN
dti-3495	113	22	as	as	ADP
dti-3495	113	23	combined	combine	VERB
dti-3495	113	24	scores	score	NOUN
dti-3495	113	25	0.7	0.7	NUM
dti-3495	113	26	or	or	CCONJ
dti-3495	113	27	higher	high	ADJ
dti-3495	113	28	.	.	PUNCT
dti-3495	114	1	further	far	ADV
dti-3495	114	2	,	,	PUNCT
dti-3495	114	3	in	in	ADP
dti-3495	114	4	silico	silico	NOUN
dti-3495	114	5	anti	anti	ADJ
dti-3495	114	6	-	-	ADJ
dti-3495	114	7	diabetic	diabetic	ADJ
dti-3495	114	8	potential	potential	NOUN
dti-3495	114	9	of	of	ADP
dti-3495	114	10	vigna	vigna	PROPN
dti-3495	114	11	unguiculata74	unguiculata74	PUNCT
dti-3495	115	1	©	©	PROPN
dti-3495	115	2	2025	2025	NUM
dti-3495	115	3	the	the	DET
dti-3495	115	4	authors	author	NOUN
dti-3495	115	5	.	.	PUNCT
dti-3495	116	1	drug	drug	NOUN
dti-3495	116	2	target	target	NOUN
dti-3495	116	3	insights	insight	NOUN
dti-3495	116	4	issn	issn	VERB
dti-3495	116	5	1177	1177	NUM
dti-3495	116	6	-	-	SYM
dti-3495	116	7	3928	3928	NUM
dti-3495	116	8	www.aboutscience.eu/dti	www.aboutscience.eu/dti	VERB
dti-3495	116	9	the	the	DET
dti-3495	116	10	smiles	smile	NOUN
dti-3495	116	11	notation	notation	NOUN
dti-3495	116	12	of	of	ADP
dti-3495	116	13	each	each	DET
dti-3495	116	14	compound	compound	NOUN
dti-3495	116	15	was	be	AUX
dti-3495	116	16	inputted	inputte	VERB
dti-3495	116	17	into	into	ADP
dti-3495	116	18	the	the	DET
dti-3495	116	19	swiss	swiss	ADJ
dti-3495	116	20	target	target	NOUN
dti-3495	116	21	prediction	prediction	NOUN
dti-3495	116	22	web	web	NOUN
dti-3495	116	23	application	application	NOUN
dti-3495	116	24	to	to	PART
dti-3495	116	25	predict	predict	VERB
dti-3495	116	26	targets	target	NOUN
dti-3495	116	27	by	by	ADP
dti-3495	116	28	employing	employ	VERB
dti-3495	116	29	the	the	DET
dti-3495	116	30	reverse	reverse	ADJ
dti-3495	116	31	pharmacophore	pharmacophore	NOUN
dti-3495	116	32	mapping	mapping	NOUN
dti-3495	116	33	approach	approach	NOUN
dti-3495	116	34	and	and	CCONJ
dti-3495	116	35	predicted	predict	VERB
dti-3495	116	36	scores	score	NOUN
dti-3495	116	37	with	with	ADP
dti-3495	116	38	a	a	DET
dti-3495	116	39	probability	probability	NOUN
dti-3495	116	40	score	score	NOUN
dti-3495	116	41	of	of	ADP
dti-3495	116	42	0.7	0.7	NUM
dti-3495	116	43	.	.	PUNCT
dti-3495	117	1	in	in	ADP
dti-3495	117	2	network	network	NOUN
dti-3495	117	3	pharmacology	pharmacology	NOUN
dti-3495	117	4	,	,	PUNCT
dti-3495	117	5	this	this	DET
dti-3495	117	6	prediction	prediction	NOUN
dti-3495	117	7	is	be	AUX
dti-3495	117	8	very	very	ADV
dti-3495	117	9	commonly	commonly	ADV
dti-3495	117	10	employed	employ	VERB
dti-3495	117	11	for	for	ADP
dti-3495	117	12	the	the	DET
dti-3495	117	13	generation	generation	NOUN
dti-3495	117	14	of	of	ADP
dti-3495	117	15	possible	possible	ADJ
dti-3495	117	16	compoundtarget	compoundtarget	NOUN
dti-3495	117	17	interactions	interaction	NOUN
dti-3495	117	18	using	use	VERB
dti-3495	117	19	available	available	ADJ
dti-3495	117	20	data	datum	NOUN
dti-3495	117	21	.	.	PUNCT
dti-3495	118	1	the	the	DET
dti-3495	118	2	validation	validation	NOUN
dti-3495	118	3	of	of	ADP
dti-3495	118	4	the	the	DET
dti-3495	118	5	predicted	predict	VERB
dti-3495	118	6	targets	target	NOUN
dti-3495	118	7	and	and	CCONJ
dti-3495	118	8	subsequently	subsequently	ADV
dti-3495	118	9	comparing	compare	VERB
dti-3495	118	10	them	they	PRON
dti-3495	118	11	with	with	ADP
dti-3495	118	12	the	the	DET
dti-3495	118	13	known	know	VERB
dti-3495	118	14	dm	dm	NOUN
dti-3495	118	15	target	target	NOUN
dti-3495	118	16	is	be	AUX
dti-3495	118	17	crucial	crucial	ADJ
dti-3495	118	18	.	.	PUNCT
dti-3495	119	1	hence	hence	ADV
dti-3495	119	2	,	,	PUNCT
dti-3495	119	3	the	the	DET
dti-3495	119	4	reliability	reliability	NOUN
dti-3495	119	5	of	of	ADP
dti-3495	119	6	the	the	DET
dti-3495	119	7	predicted	predict	VERB
dti-3495	119	8	targets	target	NOUN
dti-3495	119	9	was	be	AUX
dti-3495	119	10	enhanced	enhance	VERB
dti-3495	119	11	using	use	VERB
dti-3495	119	12	publicly	publicly	ADV
dti-3495	119	13	available	available	ADJ
dti-3495	119	14	curated	curate	VERB
dti-3495	119	15	databases	database	NOUN
dti-3495	119	16	,	,	PUNCT
dti-3495	119	17	i.e.	i.e.	X
dti-3495	119	18	,	,	PUNCT
dti-3495	119	19	genecards	genecard	NOUN
dti-3495	119	20	and	and	CCONJ
dti-3495	119	21	disgenet	disgenet	NOUN
dti-3495	119	22	databases	database	NOUN
dti-3495	119	23	and	and	CCONJ
dti-3495	119	24	the	the	DET
dti-3495	119	25	predicted	predict	VERB
dti-3495	119	26	targets	target	NOUN
dti-3495	119	27	of	of	ADP
dti-3495	119	28	the	the	DET
dti-3495	119	29	sticth	sticth	NOUN
dti-3495	119	30	database	database	NOUN
dti-3495	119	31	were	be	AUX
dti-3495	119	32	compared	compare	VERB
dti-3495	119	33	.	.	PUNCT
dti-3495	120	1	microarray	microarray	PROPN
dti-3495	120	2	data	datum	NOUN
dti-3495	120	3	analysis	analysis	NOUN
dti-3495	120	4	in	in	ADP
dti-3495	120	5	order	order	NOUN
dti-3495	120	6	to	to	PART
dti-3495	120	7	validate	validate	VERB
dti-3495	120	8	the	the	DET
dti-3495	120	9	findings	finding	NOUN
dti-3495	120	10	of	of	ADP
dti-3495	120	11	the	the	DET
dti-3495	120	12	study	study	NOUN
dti-3495	120	13	,	,	PUNCT
dti-3495	120	14	three	three	NUM
dti-3495	120	15	microarray	microarray	NOUN
dti-3495	120	16	datasets	dataset	NOUN
dti-3495	120	17	,	,	PUNCT
dti-3495	120	18	including	include	VERB
dti-3495	120	19	gse22435	gse22435	NOUN
dti-3495	120	20	,	,	PUNCT
dti-3495	120	21	gse43950	gse43950	NOUN
dti-3495	120	22	,	,	PUNCT
dti-3495	120	23	and	and	CCONJ
dti-3495	120	24	gse92724	gse92724	PROPN
dti-3495	120	25	,	,	PUNCT
dti-3495	120	26	were	be	AUX
dti-3495	120	27	obtained	obtain	VERB
dti-3495	120	28	from	from	ADP
dti-3495	120	29	the	the	DET
dti-3495	120	30	ncbi	ncbi	PROPN
dti-3495	120	31	geo	geo	PROPN
dti-3495	120	32	database	database	PROPN
dti-3495	120	33	(	(	PUNCT
dti-3495	120	34	online	online	ADJ
dti-3495	120	35	)	)	PUNCT
dti-3495	120	36	(	(	PUNCT
dti-3495	120	37	28	28	NUM
dti-3495	120	38	)	)	PUNCT
dti-3495	120	39	.	.	PUNCT
dti-3495	121	1	geo	geo	PROPN
dti-3495	121	2	is	be	AUX
dti-3495	121	3	a	a	DET
dti-3495	121	4	high	high	ADJ
dti-3495	121	5	-	-	PUNCT
dti-3495	121	6	throughput	throughput	NOUN
dti-3495	121	7	gene	gene	NOUN
dti-3495	121	8	expression	expression	NOUN
dti-3495	121	9	data	datum	NOUN
dti-3495	121	10	repository	repository	NOUN
dti-3495	121	11	,	,	PUNCT
dti-3495	121	12	including	include	VERB
dti-3495	121	13	microarray	microarray	NOUN
dti-3495	121	14	and	and	CCONJ
dti-3495	121	15	hybridization	hybridization	NOUN
dti-3495	121	16	arrays	array	VERB
dti-3495	121	17	.	.	PUNCT
dti-3495	122	1	in	in	ADP
dti-3495	122	2	this	this	DET
dti-3495	122	3	study	study	NOUN
dti-3495	122	4	,	,	PUNCT
dti-3495	122	5	degs	deg	NOUN
dti-3495	122	6	were	be	AUX
dti-3495	122	7	analyzed	analyze	VERB
dti-3495	122	8	using	use	VERB
dti-3495	122	9	the	the	DET
dti-3495	122	10	limma	limma	NOUN
dti-3495	122	11	r	r	NOUN
dti-3495	122	12	package	package	NOUN
dti-3495	122	13	.	.	PUNCT
dti-3495	123	1	limma	limma	PROPN
dti-3495	123	2	is	be	AUX
dti-3495	123	3	widely	widely	ADV
dti-3495	123	4	known	know	VERB
dti-3495	123	5	for	for	ADP
dti-3495	123	6	its	its	PRON
dti-3495	123	7	efficient	efficient	ADJ
dti-3495	123	8	tools	tool	NOUN
dti-3495	123	9	for	for	ADP
dti-3495	123	10	reading	reading	NOUN
dti-3495	123	11	,	,	PUNCT
dti-3495	123	12	normalizing	normalizing	NOUN
dti-3495	123	13	,	,	PUNCT
dti-3495	123	14	and	and	CCONJ
dti-3495	123	15	analyzing	analyze	VERB
dti-3495	123	16	gene	gene	NOUN
dti-3495	123	17	expression	expression	NOUN
dti-3495	123	18	data	datum	NOUN
dti-3495	123	19	for	for	ADP
dti-3495	123	20	degs	deg	NOUN
dti-3495	123	21	,	,	PUNCT
dti-3495	123	22	and	and	CCONJ
dti-3495	123	23	hence	hence	ADV
dti-3495	123	24	,	,	PUNCT
dti-3495	123	25	it	it	PRON
dti-3495	123	26	is	be	AUX
dti-3495	123	27	the	the	DET
dti-3495	123	28	first	first	ADJ
dti-3495	123	29	preferred	preferred	ADJ
dti-3495	123	30	choice	choice	NOUN
dti-3495	123	31	for	for	ADP
dti-3495	123	32	high	high	ADJ
dti-3495	123	33	-	-	PUNCT
dti-3495	123	34	throughput	throughput	NOUN
dti-3495	123	35	and	and	CCONJ
dti-3495	123	36	microarray	microarray	PROPN
dti-3495	123	37	data	datum	NOUN
dti-3495	123	38	.	.	PUNCT
dti-3495	124	1	screening	screen	VERB
dti-3495	124	2	criteria	criterion	NOUN
dti-3495	124	3	to	to	PART
dti-3495	124	4	identify	identify	VERB
dti-3495	124	5	candidate	candidate	NOUN
dti-3495	124	6	genes	gene	NOUN
dti-3495	124	7	were	be	AUX
dti-3495	124	8	adjusted	adjust	VERB
dti-3495	124	9	p	p	ADJ
dti-3495	124	10	-	-	PUNCT
dti-3495	124	11	value	value	NOUN
dti-3495	124	12	less	less	ADJ
dti-3495	124	13	than	than	ADP
dti-3495	124	14	0.05	0.05	NUM
dti-3495	124	15	and	and	CCONJ
dti-3495	124	16	absolute	absolute	ADJ
dti-3495	124	17	value	value	NOUN
dti-3495	124	18	of	of	ADP
dti-3495	124	19	log	log	NOUN
dti-3495	124	20	(	(	PUNCT
dti-3495	124	21	fold	fold	NOUN
dti-3495	124	22	change	change	NOUN
dti-3495	124	23	)	)	PUNCT
dti-3495	124	24	greater	great	ADJ
dti-3495	124	25	than	than	ADP
dti-3495	124	26	1.0	1.0	NUM
dti-3495	124	27	but	but	CCONJ
dti-3495	124	28	less	less	ADJ
dti-3495	124	29	than	than	ADP
dti-3495	124	30	−1.0	−1.0	PROPN
dti-3495	124	31	.	.	PUNCT
dti-3495	125	1	in	in	ADP
dti-3495	125	2	the	the	DET
dti-3495	125	3	r	r	NOUN
dti-3495	125	4	program	program	NOUN
dti-3495	125	5	,	,	PUNCT
dti-3495	125	6	we	we	PRON
dti-3495	125	7	used	use	VERB
dti-3495	125	8	the	the	DET
dti-3495	125	9	ggplot2	ggplot2	PROPN
dti-3495	125	10	package	package	NOUN
dti-3495	125	11	to	to	PART
dti-3495	125	12	create	create	VERB
dti-3495	125	13	a	a	DET
dti-3495	125	14	volcano	volcano	NOUN
dti-3495	125	15	plot	plot	NOUN
dti-3495	125	16	to	to	PART
dti-3495	125	17	differentiate	differentiate	VERB
dti-3495	125	18	between	between	ADP
dti-3495	125	19	statistically	statistically	ADV
dti-3495	125	20	significant	significant	ADJ
dti-3495	125	21	and	and	CCONJ
dti-3495	125	22	nonsignificant	nonsignificant	ADJ
dti-3495	125	23	genes	gene	NOUN
dti-3495	125	24	.	.	PUNCT
dti-3495	126	1	pathway	pathway	NOUN
dti-3495	126	2	and	and	CCONJ
dti-3495	126	3	functional	functional	ADJ
dti-3495	126	4	enrichment	enrichment	NOUN
dti-3495	126	5	analysis	analysis	NOUN
dti-3495	126	6	the	the	DET
dti-3495	126	7	database	database	NOUN
dti-3495	126	8	for	for	ADP
dti-3495	126	9	annotation	annotation	NOUN
dti-3495	126	10	,	,	PUNCT
dti-3495	126	11	visualization	visualization	NOUN
dti-3495	126	12	,	,	PUNCT
dti-3495	126	13	and	and	CCONJ
dti-3495	126	14	integrated	integrated	ADJ
dti-3495	126	15	discovery	discovery	NOUN
dti-3495	126	16	(	(	PUNCT
dti-3495	126	17	david	david	PROPN
dti-3495	126	18	)	)	PUNCT
dti-3495	126	19	was	be	AUX
dti-3495	126	20	employed	employ	VERB
dti-3495	126	21	to	to	PART
dti-3495	126	22	carry	carry	VERB
dti-3495	126	23	out	out	ADP
dti-3495	126	24	functional	functional	ADJ
dti-3495	126	25	annotation	annotation	NOUN
dti-3495	126	26	and	and	CCONJ
dti-3495	126	27	enrichment	enrichment	NOUN
dti-3495	126	28	analysis	analysis	NOUN
dti-3495	126	29	(	(	PUNCT
dti-3495	126	30	29	29	NUM
dti-3495	126	31	)	)	PUNCT
dti-3495	126	32	.	.	PUNCT
dti-3495	127	1	key	key	ADJ
dti-3495	127	2	targets	target	NOUN
dti-3495	127	3	were	be	AUX
dti-3495	127	4	examined	examine	VERB
dti-3495	127	5	using	use	VERB
dti-3495	127	6	david	david	PROPN
dti-3495	127	7	to	to	PART
dti-3495	127	8	predict	predict	VERB
dti-3495	127	9	functions	function	NOUN
dti-3495	127	10	across	across	ADP
dti-3495	127	11	three	three	NUM
dti-3495	127	12	categories	category	NOUN
dti-3495	127	13	:	:	PUNCT
dti-3495	127	14	biological	biological	ADJ
dti-3495	127	15	process	process	NOUN
dti-3495	127	16	(	(	PUNCT
dti-3495	127	17	bp	bp	PROPN
dti-3495	127	18	)	)	PUNCT
dti-3495	127	19	,	,	PUNCT
dti-3495	127	20	molecular	molecular	ADJ
dti-3495	127	21	function	function	NOUN
dti-3495	127	22	(	(	PUNCT
dti-3495	127	23	mf	mf	X
dti-3495	127	24	)	)	PUNCT
dti-3495	127	25	,	,	PUNCT
dti-3495	127	26	and	and	CCONJ
dti-3495	127	27	cellular	cellular	ADJ
dti-3495	127	28	component	component	NOUN
dti-3495	127	29	(	(	PUNCT
dti-3495	127	30	cc	cc	NOUN
dti-3495	127	31	)	)	PUNCT
dti-3495	127	32	.	.	PUNCT
dti-3495	128	1	a	a	DET
dti-3495	128	2	threshold	threshold	NOUN
dti-3495	128	3	of	of	ADP
dti-3495	128	4	an	an	DET
dti-3495	128	5	adjusted	adjust	VERB
dti-3495	128	6	p	p	NOUN
dti-3495	128	7	-	-	PUNCT
dti-3495	128	8	value	value	NOUN
dti-3495	128	9	≤	≤	NOUN
dti-3495	128	10	0.05	0.05	NUM
dti-3495	128	11	was	be	AUX
dti-3495	128	12	used	use	VERB
dti-3495	128	13	,	,	PUNCT
dti-3495	128	14	and	and	CCONJ
dti-3495	128	15	the	the	DET
dti-3495	128	16	top	top	ADJ
dti-3495	128	17	10	10	NUM
dti-3495	128	18	gene	gene	NOUN
dti-3495	128	19	ontology	ontology	NOUN
dti-3495	128	20	(	(	PUNCT
dti-3495	128	21	go	go	VERB
dti-3495	128	22	)	)	PUNCT
dti-3495	128	23	enrichments	enrichment	NOUN
dti-3495	128	24	and	and	CCONJ
dti-3495	128	25	the	the	DET
dti-3495	128	26	top	top	ADJ
dti-3495	128	27	10	10	NUM
dti-3495	128	28	kegg	kegg	NOUN
dti-3495	128	29	pathways	pathway	NOUN
dti-3495	128	30	with	with	ADP
dti-3495	128	31	the	the	DET
dti-3495	128	32	highest	high	ADJ
dti-3495	128	33	counts	count	NOUN
dti-3495	128	34	were	be	AUX
dti-3495	128	35	selected	select	VERB
dti-3495	128	36	for	for	ADP
dti-3495	128	37	further	further	ADJ
dti-3495	128	38	exploration	exploration	NOUN
dti-3495	128	39	.	.	PUNCT
dti-3495	129	1	network	network	NOUN
dti-3495	129	2	construction	construction	NOUN
dti-3495	129	3	network	network	NOUN
dti-3495	129	4	analysis	analysis	NOUN
dti-3495	129	5	was	be	AUX
dti-3495	129	6	conducted	conduct	VERB
dti-3495	129	7	to	to	PART
dti-3495	129	8	elucidate	elucidate	VERB
dti-3495	129	9	the	the	DET
dti-3495	129	10	mechanisms	mechanism	NOUN
dti-3495	129	11	through	through	ADP
dti-3495	129	12	which	which	PRON
dti-3495	129	13	v.	v.	PROPN
dti-3495	129	14	unguiculata	unguiculata	PROPN
dti-3495	129	15	affects	affect	VERB
dti-3495	129	16	t2	t2	PROPN
dti-3495	129	17	dm	dm	PROPN
dti-3495	129	18	.	.	PUNCT
dti-3495	130	1	this	this	DET
dti-3495	130	2	analysis	analysis	NOUN
dti-3495	130	3	was	be	AUX
dti-3495	130	4	facilitated	facilitate	VERB
dti-3495	130	5	by	by	ADP
dti-3495	130	6	cytoscape	cytoscape	NOUN
dti-3495	130	7	3.8.0	3.8.0	NUM
dti-3495	130	8	(	(	PUNCT
dti-3495	130	9	30	30	NUM
dti-3495	130	10	)	)	PUNCT
dti-3495	130	11	,	,	PUNCT
dti-3495	130	12	a	a	DET
dti-3495	130	13	software	software	NOUN
dti-3495	130	14	platform	platform	NOUN
dti-3495	130	15	that	that	PRON
dti-3495	130	16	provides	provide	VERB
dti-3495	130	17	tools	tool	NOUN
dti-3495	130	18	for	for	ADP
dti-3495	130	19	importing	importing	NOUN
dti-3495	130	20	,	,	PUNCT
dti-3495	130	21	visualizing	visualize	VERB
dti-3495	130	22	,	,	PUNCT
dti-3495	130	23	and	and	CCONJ
dti-3495	130	24	analyzing	analyze	VERB
dti-3495	130	25	biomolecular	biomolecular	ADJ
dti-3495	130	26	interaction	interaction	NOUN
dti-3495	130	27	networks	network	NOUN
dti-3495	130	28	.	.	PUNCT
dti-3495	131	1	in	in	ADP
dti-3495	131	2	the	the	DET
dti-3495	131	3	constructed	construct	VERB
dti-3495	131	4	network	network	NOUN
dti-3495	131	5	,	,	PUNCT
dti-3495	131	6	the	the	DET
dti-3495	131	7	nodes	node	NOUN
dti-3495	131	8	are	be	AUX
dti-3495	131	9	the	the	DET
dti-3495	131	10	target	target	NOUN
dti-3495	131	11	genes	gene	NOUN
dti-3495	131	12	,	,	PUNCT
dti-3495	131	13	and	and	CCONJ
dti-3495	131	14	the	the	DET
dti-3495	131	15	edges	edge	NOUN
dti-3495	131	16	are	be	AUX
dti-3495	131	17	the	the	DET
dti-3495	131	18	interactions	interaction	NOUN
dti-3495	131	19	between	between	ADP
dti-3495	131	20	the	the	DET
dti-3495	131	21	active	active	ADJ
dti-3495	131	22	compounds	compound	NOUN
dti-3495	131	23	and	and	CCONJ
dti-3495	131	24	the	the	DET
dti-3495	131	25	target	target	NOUN
dti-3495	131	26	genes	gene	NOUN
dti-3495	131	27	.	.	PUNCT
dti-3495	132	1	to	to	PART
dti-3495	132	2	define	define	VERB
dti-3495	132	3	the	the	DET
dti-3495	132	4	network	network	NOUN
dti-3495	132	5	topology	topology	NOUN
dti-3495	132	6	,	,	PUNCT
dti-3495	132	7	the	the	DET
dti-3495	132	8	degree	degree	NOUN
dti-3495	132	9	centrality	centrality	NOUN
dti-3495	132	10	of	of	ADP
dti-3495	132	11	each	each	DET
dti-3495	132	12	compound	compound	NOUN
dti-3495	132	13	,	,	PUNCT
dti-3495	132	14	target	target	NOUN
dti-3495	132	15	gene	gene	NOUN
dti-3495	132	16	,	,	PUNCT
dti-3495	132	17	or	or	CCONJ
dti-3495	132	18	pathway	pathway	NOUN
dti-3495	132	19	was	be	AUX
dti-3495	132	20	calculated	calculate	VERB
dti-3495	132	21	using	use	VERB
dti-3495	132	22	the	the	DET
dti-3495	132	23	network	network	NOUN
dti-3495	132	24	analyzer	analyzer	NOUN
dti-3495	132	25	of	of	ADP
dti-3495	132	26	cytoscape	cytoscape	NOUN
dti-3495	132	27	.	.	PUNCT
dti-3495	133	1	targets	target	NOUN
dti-3495	133	2	that	that	PRON
dti-3495	133	3	showed	show	VERB
dti-3495	133	4	the	the	DET
dti-3495	133	5	maximum	maximum	ADJ
dti-3495	133	6	level	level	NOUN
dti-3495	133	7	of	of	ADP
dti-3495	133	8	interconnectedness	interconnectedness	NOUN
dti-3495	133	9	were	be	AUX
dti-3495	133	10	termed	term	VERB
dti-3495	133	11	‘	'	PUNCT
dti-3495	133	12	key	key	ADJ
dti-3495	133	13	targets	target	NOUN
dti-3495	133	14	’	'	PUNCT
dti-3495	133	15	.	.	PUNCT
dti-3495	134	1	protein	protein	NOUN
dti-3495	134	2	–	–	PUNCT
dti-3495	134	3	protein	protein	NOUN
dti-3495	134	4	interaction	interaction	NOUN
dti-3495	134	5	network	network	NOUN
dti-3495	134	6	construction	construction	NOUN
dti-3495	134	7	ppis	ppi	VERB
dti-3495	134	8	are	be	AUX
dti-3495	134	9	essential	essential	ADJ
dti-3495	134	10	because	because	SCONJ
dti-3495	134	11	they	they	PRON
dti-3495	134	12	are	be	AUX
dti-3495	134	13	highly	highly	ADV
dti-3495	134	14	flexible	flexible	ADJ
dti-3495	134	15	,	,	PUNCT
dti-3495	134	16	tunable	tunable	NOUN
dti-3495	134	17	,	,	PUNCT
dti-3495	134	18	and	and	CCONJ
dti-3495	134	19	selective	selective	ADJ
dti-3495	134	20	processes	process	NOUN
dti-3495	134	21	.	.	PUNCT
dti-3495	135	1	the	the	DET
dti-3495	135	2	search	search	NOUN
dti-3495	135	3	tool	tool	NOUN
dti-3495	135	4	for	for	ADP
dti-3495	135	5	the	the	DET
dti-3495	135	6	retrieval	retrieval	NOUN
dti-3495	135	7	of	of	ADP
dti-3495	135	8	interacting	interact	VERB
dti-3495	135	9	genes	gene	NOUN
dti-3495	135	10	/	/	SYM
dti-3495	135	11	proteins	protein	NOUN
dti-3495	135	12	(	(	PUNCT
dti-3495	135	13	string	string	NOUN
dti-3495	135	14	)	)	PUNCT
dti-3495	135	15	database	database	NOUN
dti-3495	135	16	(	(	PUNCT
dti-3495	135	17	31	31	NUM
dti-3495	135	18	)	)	PUNCT
dti-3495	135	19	was	be	AUX
dti-3495	135	20	then	then	ADV
dti-3495	135	21	used	use	VERB
dti-3495	135	22	to	to	PART
dti-3495	135	23	search	search	VERB
dti-3495	135	24	for	for	ADP
dti-3495	135	25	the	the	DET
dti-3495	135	26	functional	functional	ADJ
dti-3495	135	27	relationship	relationship	NOUN
dti-3495	135	28	between	between	ADP
dti-3495	135	29	the	the	DET
dti-3495	135	30	above	above	ADJ
dti-3495	135	31	identified	identify	VERB
dti-3495	135	32	key	key	ADJ
dti-3495	135	33	targets	target	NOUN
dti-3495	135	34	,	,	PUNCT
dti-3495	135	35	which	which	PRON
dti-3495	135	36	requires	require	VERB
dti-3495	135	37	the	the	DET
dti-3495	135	38	combined	combine	VERB
dti-3495	135	39	score	score	NOUN
dti-3495	135	40	to	to	PART
dti-3495	135	41	be	be	AUX
dti-3495	135	42	more	more	ADJ
dti-3495	135	43	than	than	ADP
dti-3495	135	44	0.9	0.9	NUM
dti-3495	135	45	,	,	PUNCT
dti-3495	135	46	while	while	SCONJ
dti-3495	135	47	the	the	DET
dti-3495	135	48	high	high	ADJ
dti-3495	135	49	confidence	confidence	NOUN
dti-3495	135	50	score	score	NOUN
dti-3495	135	51	was	be	AUX
dti-3495	135	52	applied	apply	VERB
dti-3495	135	53	to	to	PART
dti-3495	135	54	enhance	enhance	VERB
dti-3495	135	55	the	the	DET
dti-3495	135	56	reliability	reliability	NOUN
dti-3495	135	57	of	of	ADP
dti-3495	135	58	the	the	DET
dti-3495	135	59	data	datum	NOUN
dti-3495	135	60	.	.	PUNCT
dti-3495	136	1	a	a	DET
dti-3495	136	2	high	high	ADJ
dti-3495	136	3	threshold	threshold	NOUN
dti-3495	136	4	was	be	AUX
dti-3495	136	5	selected	select	VERB
dti-3495	136	6	to	to	PART
dti-3495	136	7	ensure	ensure	VERB
dti-3495	136	8	that	that	SCONJ
dti-3495	136	9	interactions	interaction	NOUN
dti-3495	136	10	include	include	VERB
dti-3495	136	11	all	all	DET
dti-3495	136	12	the	the	DET
dti-3495	136	13	relevant	relevant	ADJ
dti-3495	136	14	potential	potential	ADJ
dti-3495	136	15	interactions	interaction	NOUN
dti-3495	136	16	to	to	PART
dti-3495	136	17	enhance	enhance	VERB
dti-3495	136	18	the	the	DET
dti-3495	136	19	reliability	reliability	NOUN
dti-3495	136	20	of	of	ADP
dti-3495	136	21	the	the	DET
dti-3495	136	22	network	network	NOUN
dti-3495	136	23	interaction	interaction	NOUN
dti-3495	136	24	.	.	PUNCT
dti-3495	137	1	these	these	DET
dti-3495	137	2	interactions	interaction	NOUN
dti-3495	137	3	involved	involve	VERB
dti-3495	137	4	the	the	DET
dti-3495	137	5	use	use	NOUN
dti-3495	137	6	of	of	ADP
dti-3495	137	7	experimental	experimental	ADJ
dti-3495	137	8	data	datum	NOUN
dti-3495	137	9	such	such	ADJ
dti-3495	137	10	as	as	ADP
dti-3495	137	11	protein	protein	NOUN
dti-3495	137	12	homology	homology	NOUN
dti-3495	137	13	,	,	PUNCT
dti-3495	137	14	or	or	CCONJ
dti-3495	137	15	physical	physical	ADJ
dti-3495	137	16	type	type	NOUN
dti-3495	137	17	of	of	ADP
dti-3495	137	18	interaction	interaction	NOUN
dti-3495	137	19	,	,	PUNCT
dti-3495	137	20	and	and	CCONJ
dti-3495	137	21	co	co	ADJ
dti-3495	137	22	-	-	NOUN
dti-3495	137	23	expression	expression	ADJ
dti-3495	137	24	data	datum	NOUN
dti-3495	137	25	,	,	PUNCT
dti-3495	137	26	with	with	ADP
dti-3495	137	27	the	the	DET
dti-3495	137	28	intention	intention	NOUN
dti-3495	137	29	to	to	PART
dti-3495	137	30	make	make	VERB
dti-3495	137	31	a	a	DET
dti-3495	137	32	more	more	ADV
dti-3495	137	33	biologically	biologically	ADV
dti-3495	137	34	relevant	relevant	ADJ
dti-3495	137	35	network	network	NOUN
dti-3495	137	36	by	by	ADP
dti-3495	137	37	employing	employ	VERB
dti-3495	137	38	these	these	DET
dti-3495	137	39	additional	additional	ADJ
dti-3495	137	40	filters	filter	NOUN
dti-3495	137	41	.	.	PUNCT
dti-3495	138	1	the	the	DET
dti-3495	138	2	obtained	obtain	VERB
dti-3495	138	3	ppi	ppi	NOUN
dti-3495	138	4	network	network	NOUN
dti-3495	138	5	was	be	AUX
dti-3495	138	6	then	then	ADV
dti-3495	138	7	subjected	subject	VERB
dti-3495	138	8	to	to	ADP
dti-3495	138	9	the	the	DET
dti-3495	138	10	next	next	ADJ
dti-3495	138	11	step	step	NOUN
dti-3495	138	12	of	of	ADP
dti-3495	138	13	filtration	filtration	NOUN
dti-3495	138	14	and	and	CCONJ
dti-3495	138	15	analysis	analysis	NOUN
dti-3495	138	16	using	use	VERB
dti-3495	138	17	the	the	DET
dti-3495	138	18	cytohubba	cytohubba	NOUN
dti-3495	138	19	plugin	plugin	NOUN
dti-3495	138	20	in	in	ADP
dti-3495	138	21	cytoscape	cytoscape	NOUN
dti-3495	138	22	to	to	PART
dti-3495	138	23	identify	identify	VERB
dti-3495	138	24	essential	essential	ADJ
dti-3495	138	25	regulatory	regulatory	ADJ
dti-3495	138	26	genes	gene	NOUN
dti-3495	138	27	and	and	CCONJ
dti-3495	138	28	potential	potential	ADJ
dti-3495	138	29	targets	target	NOUN
dti-3495	138	30	.	.	PUNCT
dti-3495	139	1	virtual	virtual	ADJ
dti-3495	139	2	screening	screen	VERB
dti-3495	139	3	the	the	DET
dti-3495	139	4	protein	protein	NOUN
dti-3495	139	5	targets	target	NOUN
dti-3495	139	6	identified	identify	VERB
dti-3495	139	7	during	during	ADP
dti-3495	139	8	the	the	DET
dti-3495	139	9	protein	protein	NOUN
dti-3495	139	10	-	-	PUNCT
dti-3495	139	11	protein	protein	NOUN
dti-3495	139	12	interaction	interaction	NOUN
dti-3495	139	13	network	network	NOUN
dti-3495	139	14	were	be	AUX
dti-3495	139	15	then	then	ADV
dti-3495	139	16	further	far	ADV
dti-3495	139	17	validated	validate	VERB
dti-3495	139	18	through	through	ADP
dti-3495	139	19	molecular	molecular	ADJ
dti-3495	139	20	docking	docking	NOUN
dti-3495	139	21	,	,	PUNCT
dti-3495	139	22	which	which	PRON
dti-3495	139	23	is	be	AUX
dti-3495	139	24	a	a	DET
dti-3495	139	25	rapid	rapid	ADJ
dti-3495	139	26	computational	computational	ADJ
dti-3495	139	27	technique	technique	NOUN
dti-3495	139	28	.	.	PUNCT
dti-3495	140	1	information	information	NOUN
dti-3495	140	2	about	about	ADP
dti-3495	140	3	the	the	DET
dti-3495	140	4	candidate	candidate	NOUN
dti-3495	140	5	target	target	NOUN
dti-3495	140	6	was	be	AUX
dti-3495	140	7	obtained	obtain	VERB
dti-3495	140	8	from	from	ADP
dti-3495	140	9	the	the	DET
dti-3495	140	10	x	x	NOUN
dti-3495	140	11	-	-	NOUN
dti-3495	140	12	ray	ray	NOUN
dti-3495	140	13	crystal	crystal	NOUN
dti-3495	140	14	structures	structure	NOUN
dti-3495	140	15	offered	offer	VERB
dti-3495	140	16	under	under	ADP
dti-3495	140	17	the	the	DET
dti-3495	140	18	rcsb	rcsb	ADJ
dti-3495	140	19	protein	protein	NOUN
dti-3495	140	20	data	datum	NOUN
dti-3495	140	21	bank	bank	NOUN
dti-3495	140	22	(	(	PUNCT
dti-3495	140	23	32	32	NUM
dti-3495	140	24	)	)	PUNCT
dti-3495	140	25	.	.	PUNCT
dti-3495	141	1	structural	structural	ADJ
dti-3495	141	2	optimization	optimization	NOUN
dti-3495	141	3	of	of	ADP
dti-3495	141	4	the	the	DET
dti-3495	141	5	complex	complex	NOUN
dti-3495	141	6	was	be	AUX
dti-3495	141	7	done	do	VERB
dti-3495	141	8	by	by	ADP
dti-3495	141	9	ucsf	ucsf	PROPN
dti-3495	141	10	chimera	chimera	PROPN
dti-3495	141	11	(	(	PUNCT
dti-3495	141	12	33	33	NUM
dti-3495	141	13	)	)	PUNCT
dti-3495	141	14	,	,	PUNCT
dti-3495	141	15	while	while	SCONJ
dti-3495	141	16	protein	protein	NOUN
dti-3495	141	17	targets	target	NOUN
dti-3495	141	18	and	and	CCONJ
dti-3495	141	19	probable	probable	ADJ
dti-3495	141	20	binding	bind	VERB
dti-3495	141	21	sites	site	NOUN
dti-3495	141	22	were	be	AUX
dti-3495	141	23	predicted	predict	VERB
dti-3495	141	24	using	use	VERB
dti-3495	141	25	the	the	DET
dti-3495	141	26	castp	castp	ADJ
dti-3495	141	27	site	site	NOUN
dti-3495	141	28	mapping	mapping	NOUN
dti-3495	141	29	tool	tool	NOUN
dti-3495	141	30	(	(	PUNCT
dti-3495	141	31	34	34	NUM
dti-3495	141	32	)	)	PUNCT
dti-3495	141	33	.	.	PUNCT
dti-3495	142	1	virtual	virtual	ADJ
dti-3495	142	2	screening	screening	NOUN
dti-3495	142	3	of	of	ADP
dti-3495	142	4	the	the	DET
dti-3495	142	5	reported	report	VERB
dti-3495	142	6	compounds	compound	NOUN
dti-3495	142	7	was	be	AUX
dti-3495	142	8	performed	perform	VERB
dti-3495	142	9	using	use	VERB
dti-3495	142	10	the	the	DET
dti-3495	142	11	autodock	autodock	NOUN
dti-3495	142	12	vina	vina	NOUN
dti-3495	142	13	in	in	ADP
dti-3495	142	14	ubuntu	ubuntu	PROPN
dti-3495	142	15	(	(	PUNCT
dti-3495	142	16	35,36	35,36	NUM
dti-3495	142	17	)	)	PUNCT
dti-3495	142	18	in	in	ADP
dti-3495	142	19	order	order	NOUN
dti-3495	142	20	to	to	PART
dti-3495	142	21	assess	assess	VERB
dti-3495	142	22	the	the	DET
dti-3495	142	23	binding	binding	NOUN
dti-3495	142	24	of	of	ADP
dti-3495	142	25	the	the	DET
dti-3495	142	26	core	core	NOUN
dti-3495	142	27	targets	target	NOUN
dti-3495	142	28	with	with	ADP
dti-3495	142	29	the	the	DET
dti-3495	142	30	active	active	ADJ
dti-3495	142	31	compounds	compound	NOUN
dti-3495	142	32	.	.	PUNCT
dti-3495	143	1	the	the	DET
dti-3495	143	2	favorable	favorable	ADJ
dti-3495	143	3	docked	docked	ADJ
dti-3495	143	4	conformations	conformation	NOUN
dti-3495	143	5	were	be	AUX
dti-3495	143	6	considered	consider	VERB
dti-3495	143	7	in	in	ADP
dti-3495	143	8	terms	term	NOUN
dti-3495	143	9	of	of	ADP
dti-3495	143	10	binding	bind	VERB
dti-3495	143	11	energies	energy	NOUN
dti-3495	143	12	.	.	PUNCT
dti-3495	144	1	docking	dock	VERB
dti-3495	144	2	scores	score	NOUN
dti-3495	144	3	,	,	PUNCT
dti-3495	144	4	which	which	PRON
dti-3495	144	5	reflect	reflect	VERB
dti-3495	144	6	the	the	DET
dti-3495	144	7	strength	strength	NOUN
dti-3495	144	8	and	and	CCONJ
dti-3495	144	9	stability	stability	NOUN
dti-3495	144	10	of	of	ADP
dti-3495	144	11	the	the	DET
dti-3495	144	12	compoundtarget	compoundtarget	NOUN
dti-3495	144	13	interactions	interaction	NOUN
dti-3495	144	14	,	,	PUNCT
dti-3495	144	15	were	be	AUX
dti-3495	144	16	used	use	VERB
dti-3495	144	17	as	as	ADP
dti-3495	144	18	primary	primary	ADJ
dti-3495	144	19	criteria	criterion	NOUN
dti-3495	144	20	for	for	ADP
dti-3495	144	21	selecting	select	VERB
dti-3495	144	22	promising	promising	ADJ
dti-3495	144	23	compounds	compound	NOUN
dti-3495	144	24	and	and	CCONJ
dti-3495	144	25	their	their	PRON
dti-3495	144	26	targets	target	NOUN
dti-3495	144	27	.	.	PUNCT
dti-3495	145	1	the	the	DET
dti-3495	145	2	results	result	NOUN
dti-3495	145	3	of	of	ADP
dti-3495	145	4	the	the	DET
dti-3495	145	5	autodock	autodock	NOUN
dti-3495	145	6	vina	vina	NOUN
dti-3495	145	7	were	be	AUX
dti-3495	145	8	validated	validate	VERB
dti-3495	145	9	using	use	VERB
dti-3495	145	10	the	the	DET
dti-3495	145	11	pyrx	pyrx	NOUN
dti-3495	145	12	software	software	NOUN
dti-3495	145	13	to	to	AUX
dti-3495	145	14	cross	cross	VERB
dti-3495	145	15	-	-	VERB
dti-3495	145	16	check	check	VERB
dti-3495	145	17	the	the	DET
dti-3495	145	18	predictive	predictive	ADJ
dti-3495	145	19	score	score	NOUN
dti-3495	145	20	of	of	ADP
dti-3495	145	21	the	the	DET
dti-3495	145	22	ligand	ligand	ADJ
dti-3495	145	23	and	and	CCONJ
dti-3495	145	24	protein	protein	NOUN
dti-3495	145	25	interaction	interaction	NOUN
dti-3495	145	26	.	.	PUNCT
dti-3495	146	1	this	this	DET
dti-3495	146	2	approach	approach	NOUN
dti-3495	146	3	ensures	ensure	VERB
dti-3495	146	4	that	that	SCONJ
dti-3495	146	5	the	the	DET
dti-3495	146	6	docking	docking	NOUN
dti-3495	146	7	results	result	NOUN
dti-3495	146	8	are	be	AUX
dti-3495	146	9	robust	robust	ADJ
dti-3495	146	10	using	use	VERB
dti-3495	146	11	multiple	multiple	ADJ
dti-3495	146	12	docking	docking	NOUN
dti-3495	146	13	methods	method	NOUN
dti-3495	146	14	.	.	PUNCT
dti-3495	147	1	visualization	visualization	NOUN
dti-3495	147	2	of	of	ADP
dti-3495	147	3	these	these	DET
dti-3495	147	4	interactions	interaction	NOUN
dti-3495	147	5	was	be	AUX
dti-3495	147	6	achieved	achieve	VERB
dti-3495	147	7	using	use	VERB
dti-3495	147	8	discovery	discovery	NOUN
dti-3495	147	9	studio	studio	NOUN
dti-3495	147	10	(	(	PUNCT
dti-3495	147	11	37	37	NUM
dti-3495	147	12	)	)	PUNCT
dti-3495	147	13	,	,	PUNCT
dti-3495	147	14	highlighting	highlight	VERB
dti-3495	147	15	the	the	DET
dti-3495	147	16	dynamics	dynamic	NOUN
dti-3495	147	17	of	of	ADP
dti-3495	147	18	compound	compound	NOUN
dti-3495	147	19	-	-	PUNCT
dti-3495	147	20	protein	protein	NOUN
dti-3495	147	21	interactions	interaction	NOUN
dti-3495	147	22	in	in	ADP
dti-3495	147	23	a	a	DET
dti-3495	147	24	visual	visual	ADJ
dti-3495	147	25	format	format	NOUN
dti-3495	147	26	.	.	PUNCT
dti-3495	148	1	md	md	PROPN
dti-3495	148	2	simulation	simulation	PROPN
dti-3495	148	3	after	after	ADP
dti-3495	148	4	the	the	DET
dti-3495	148	5	virtual	virtual	ADJ
dti-3495	148	6	screening	screening	NOUN
dti-3495	148	7	,	,	PUNCT
dti-3495	148	8	the	the	DET
dti-3495	148	9	molecular	molecular	ADJ
dti-3495	148	10	dynamic	dynamic	ADJ
dti-3495	148	11	simulation	simulation	NOUN
dti-3495	148	12	was	be	AUX
dti-3495	148	13	performed	perform	VERB
dti-3495	148	14	to	to	PART
dti-3495	148	15	assess	assess	VERB
dti-3495	148	16	structural	structural	ADJ
dti-3495	148	17	as	as	ADV
dti-3495	148	18	well	well	ADV
dti-3495	148	19	as	as	ADP
dti-3495	148	20	dynamic	dynamic	ADJ
dti-3495	148	21	stability	stability	NOUN
dti-3495	148	22	of	of	ADP
dti-3495	148	23	the	the	DET
dti-3495	148	24	ligand	ligand	ADJ
dti-3495	148	25	-	-	PUNCT
dti-3495	148	26	protein	protein	NOUN
dti-3495	148	27	complexes	complex	NOUN
dti-3495	148	28	for	for	ADP
dti-3495	148	29	50	50	NUM
dti-3495	148	30	ns	ns	NUM
dti-3495	148	31	using	use	VERB
dti-3495	148	32	gromacs	gromacs	ADJ
dti-3495	148	33	software	software	NOUN
dti-3495	148	34	2024.1	2024.1	NUM
dti-3495	148	35	(	(	PUNCT
dti-3495	148	36	38	38	NUM
dti-3495	148	37	)	)	PUNCT
dti-3495	148	38	.	.	PUNCT
dti-3495	149	1	the	the	DET
dti-3495	149	2	tip3p	tip3p	NUM
dti-3495	149	3	water	water	NOUN
dti-3495	149	4	box	box	PROPN
dti-3495	149	5	was	be	AUX
dti-3495	149	6	used	use	VERB
dti-3495	149	7	for	for	ADP
dti-3495	149	8	solvation	solvation	NOUN
dti-3495	149	9	,	,	PUNCT
dti-3495	149	10	and	and	CCONJ
dti-3495	149	11	the	the	DET
dti-3495	149	12	charmm27	charmm27	NOUN
dti-3495	149	13	,	,	PUNCT
dti-3495	149	14	i.e.	i.e.	X
dti-3495	149	15	,	,	PUNCT
dti-3495	149	16	all	all	ADJ
dti-3495	149	17	-	-	PUNCT
dti-3495	149	18	atom	atom	NOUN
dti-3495	149	19	force	force	NOUN
dti-3495	149	20	field	field	NOUN
dti-3495	149	21	,	,	PUNCT
dti-3495	149	22	was	be	AUX
dti-3495	149	23	applied	apply	VERB
dti-3495	149	24	.	.	PUNCT
dti-3495	150	1	the	the	DET
dti-3495	150	2	ligand	ligand	NOUN
dti-3495	150	3	topologies	topology	NOUN
dti-3495	150	4	were	be	AUX
dti-3495	150	5	generated	generate	VERB
dti-3495	150	6	using	use	VERB
dti-3495	150	7	the	the	DET
dti-3495	150	8	swissparam	swissparam	PROPN
dti-3495	150	9	software	software	NOUN
dti-3495	150	10	.	.	PUNCT
dti-3495	151	1	the	the	DET
dti-3495	151	2	system	system	NOUN
dti-3495	151	3	was	be	AUX
dti-3495	151	4	minimized	minimize	VERB
dti-3495	151	5	for	for	ADP
dti-3495	151	6	50000	50000	NUM
dti-3495	151	7	steps	step	NOUN
dti-3495	151	8	to	to	PART
dti-3495	151	9	remove	remove	VERB
dti-3495	151	10	the	the	DET
dti-3495	151	11	steric	steric	ADJ
dti-3495	151	12	clashes	clash	NOUN
dti-3495	151	13	using	use	VERB
dti-3495	151	14	the	the	DET
dti-3495	151	15	steepest	steep	ADJ
dti-3495	151	16	descent	descent	NOUN
dti-3495	151	17	model	model	NOUN
dti-3495	151	18	.	.	PUNCT
dti-3495	152	1	following	follow	VERB
dti-3495	152	2	the	the	DET
dti-3495	152	3	energy	energy	NOUN
dti-3495	152	4	minimization	minimization	NOUN
dti-3495	152	5	,	,	PUNCT
dti-3495	152	6	the	the	DET
dti-3495	152	7	system	system	NOUN
dti-3495	152	8	was	be	AUX
dti-3495	152	9	equilibrated	equilibrate	VERB
dti-3495	152	10	in	in	ADP
dti-3495	152	11	two	two	NUM
dti-3495	152	12	steps	step	NOUN
dti-3495	152	13	,	,	PUNCT
dti-3495	152	14	i.e.	i.e.	X
dti-3495	152	15	,	,	PUNCT
dti-3495	152	16	nvt	nvt	PROPN
dti-3495	152	17	and	and	CCONJ
dti-3495	152	18	npt	npt	PROPN
dti-3495	152	19	ensembles	ensemble	NOUN
dti-3495	152	20	by	by	ADP
dti-3495	152	21	applying	apply	VERB
dti-3495	152	22	the	the	DET
dti-3495	152	23	periodic	periodic	ADJ
dti-3495	152	24	boundary	boundary	ADJ
dti-3495	152	25	condition	condition	NOUN
dti-3495	152	26	in	in	ADP
dti-3495	152	27	all	all	DET
dti-3495	152	28	directions	direction	NOUN
dti-3495	152	29	(	(	PUNCT
dti-3495	152	30	36	36	NUM
dti-3495	152	31	)	)	PUNCT
dti-3495	152	32	.	.	PUNCT
dti-3495	153	1	during	during	ADP
dti-3495	153	2	the	the	DET
dti-3495	153	3	nvt	nvt	PROPN
dti-3495	153	4	and	and	CCONJ
dti-3495	153	5	npt	npt	PROPN
dti-3495	153	6	ensembles	ensemble	NOUN
dti-3495	153	7	,	,	PUNCT
dti-3495	153	8	the	the	DET
dti-3495	153	9	temperature	temperature	NOUN
dti-3495	153	10	was	be	AUX
dti-3495	153	11	maintained	maintain	VERB
dti-3495	153	12	at	at	ADP
dti-3495	153	13	300	300	NUM
dti-3495	153	14	k	k	NOUN
dti-3495	153	15	for	for	ADP
dti-3495	153	16	100	100	NUM
dti-3495	153	17	ps	p	NOUN
dti-3495	153	18	,	,	PUNCT
dti-3495	153	19	while	while	SCONJ
dti-3495	153	20	the	the	DET
dti-3495	153	21	npt	npt	PROPN
dti-3495	153	22	ensemble	ensemble	PROPN
dti-3495	153	23	was	be	AUX
dti-3495	153	24	maintained	maintain	VERB
dti-3495	153	25	at	at	ADP
dti-3495	153	26	100	100	NUM
dti-3495	153	27	ps	p	NOUN
dti-3495	153	28	by	by	ADP
dti-3495	153	29	keeping	keep	VERB
dti-3495	153	30	the	the	DET
dti-3495	153	31	pressure	pressure	NOUN
dti-3495	153	32	at	at	ADP
dti-3495	153	33	1	1	NUM
dti-3495	153	34	bar	bar	NOUN
dti-3495	153	35	.	.	PUNCT
dti-3495	154	1	the	the	DET
dti-3495	154	2	final	final	ADJ
dti-3495	154	3	md	md	PROPN
dti-3495	154	4	run	run	NOUN
dti-3495	154	5	was	be	AUX
dti-3495	154	6	performed	perform	VERB
dti-3495	154	7	for	for	ADP
dti-3495	154	8	100	100	NUM
dti-3495	154	9	ns	ns	NUM
dti-3495	154	10	,	,	PUNCT
dti-3495	154	11	and	and	CCONJ
dti-3495	154	12	the	the	DET
dti-3495	154	13	https://www.ncbi.nlm.nih.gov/geo/	https://www.ncbi.nlm.nih.gov/geo/	PROPN
dti-3495	154	14	sardar	sardar	PROPN
dti-3495	154	15	et	et	PROPN
dti-3495	154	16	al	al	PROPN
dti-3495	154	17	drug	drug	PROPN
dti-3495	154	18	target	target	NOUN
dti-3495	154	19	insights	insight	NOUN
dti-3495	154	20	2025	2025	NUM
dti-3495	154	21	;	;	PUNCT
dti-3495	154	22	19	19	NUM
dti-3495	154	23	:	:	SYM
dti-3495	154	24	75	75	NUM
dti-3495	154	25	©	©	PROPN
dti-3495	154	26	2025	2025	NUM
dti-3495	154	27	the	the	DET
dti-3495	154	28	authors	author	NOUN
dti-3495	154	29	.	.	PUNCT
dti-3495	155	1	published	publish	VERB
dti-3495	155	2	by	by	ADP
dti-3495	155	3	aboutscience	aboutscience	NOUN
dti-3495	155	4	www.aboutscience.eu	www.aboutscience.eu	NOUN
dti-3495	155	5	results	result	NOUN
dti-3495	155	6	were	be	AUX
dti-3495	155	7	analyzed	analyze	VERB
dti-3495	155	8	using	use	VERB
dti-3495	155	9	various	various	ADJ
dti-3495	155	10	dynamical	dynamical	ADJ
dti-3495	155	11	and	and	CCONJ
dti-3495	155	12	structural	structural	ADJ
dti-3495	155	13	properties	property	NOUN
dti-3495	155	14	(	(	PUNCT
dti-3495	155	15	39	39	NUM
dti-3495	155	16	)	)	PUNCT
dti-3495	155	17	.	.	PUNCT
dti-3495	156	1	binding	bind	VERB
dti-3495	156	2	free	free	ADJ
dti-3495	156	3	energy	energy	NOUN
dti-3495	156	4	calculations	calculation	NOUN
dti-3495	156	5	to	to	PART
dti-3495	156	6	assess	assess	VERB
dti-3495	156	7	the	the	DET
dti-3495	156	8	binding	bind	VERB
dti-3495	156	9	free	free	ADJ
dti-3495	156	10	energy	energy	NOUN
dti-3495	156	11	for	for	ADP
dti-3495	156	12	all	all	DET
dti-3495	156	13	the	the	DET
dti-3495	156	14	complexes	complex	NOUN
dti-3495	156	15	,	,	PUNCT
dti-3495	156	16	mm	mm	NOUN
dti-3495	156	17	-	-	PUNCT
dti-3495	156	18	pbsa	pbsa	NOUN
dti-3495	156	19	and	and	CCONJ
dti-3495	156	20	mm	mm	NOUN
dti-3495	156	21	-	-	PUNCT
dti-3495	156	22	gbsa	gbsa	NOUN
dti-3495	156	23	were	be	AUX
dti-3495	156	24	performed	perform	VERB
dti-3495	156	25	(	(	PUNCT
dti-3495	156	26	40	40	NUM
dti-3495	156	27	)	)	PUNCT
dti-3495	156	28	.	.	PUNCT
dti-3495	157	1	the	the	DET
dti-3495	157	2	binding	bind	VERB
dti-3495	157	3	free	free	ADJ
dti-3495	157	4	energy	energy	NOUN
dti-3495	157	5	was	be	AUX
dti-3495	157	6	calculated	calculate	VERB
dti-3495	157	7	over	over	ADP
dti-3495	157	8	the	the	DET
dti-3495	157	9	100	100	NUM
dti-3495	157	10	ns	ns	NUM
dti-3495	157	11	simulation	simulation	NOUN
dti-3495	157	12	using	use	VERB
dti-3495	157	13	md	md	PROPN
dti-3495	157	14	trajectories	trajectory	NOUN
dti-3495	157	15	,	,	PUNCT
dti-3495	157	16	and	and	CCONJ
dti-3495	157	17	the	the	DET
dti-3495	157	18	per	per	ADP
dti-3495	157	19	-	-	PUNCT
dti-3495	157	20	residue	residue	NOUN
dti-3495	157	21	decomposition	decomposition	NOUN
dti-3495	157	22	analysis	analysis	NOUN
dti-3495	157	23	was	be	AUX
dti-3495	157	24	performed	perform	VERB
dti-3495	157	25	for	for	ADP
dti-3495	157	26	both	both	DET
dti-3495	157	27	approaches	approach	NOUN
dti-3495	157	28	,	,	PUNCT
dti-3495	157	29	i.e.	i.e.	X
dti-3495	157	30	,	,	PUNCT
dti-3495	157	31	mm	mm	NOUN
dti-3495	157	32	-	-	PUNCT
dti-3495	157	33	pbsa	pbsa	NOUN
dti-3495	157	34	and	and	CCONJ
dti-3495	157	35	mm	mm	NOUN
dti-3495	157	36	-	-	PUNCT
dti-3495	157	37	gbsa	gbsa	NOUN
dti-3495	157	38	,	,	PUNCT
dti-3495	157	39	to	to	PART
dti-3495	157	40	determine	determine	VERB
dti-3495	157	41	the	the	DET
dti-3495	157	42	individual	individual	ADJ
dti-3495	157	43	residues	residue	NOUN
dti-3495	157	44	’	'	PUNCT
dti-3495	157	45	contribution	contribution	NOUN
dti-3495	157	46	towards	towards	ADP
dti-3495	157	47	the	the	DET
dti-3495	157	48	binding	bind	VERB
dti-3495	157	49	energy	energy	NOUN
dti-3495	157	50	of	of	ADP
dti-3495	157	51	the	the	DET
dti-3495	157	52	complexes	complex	NOUN
dti-3495	157	53	.	.	PUNCT
dti-3495	158	1	the	the	DET
dti-3495	158	2	binding	bind	VERB
dti-3495	158	3	free	free	ADJ
dti-3495	158	4	energy	energy	NOUN
dti-3495	158	5	calculation	calculation	NOUN
dti-3495	158	6	was	be	AUX
dti-3495	158	7	performed	perform	VERB
dti-3495	158	8	for	for	ADP
dti-3495	158	9	1000	1000	NUM
dti-3495	158	10	frames	frame	NOUN
dti-3495	158	11	(	(	PUNCT
dti-3495	158	12	30004000	30004000	NUM
dti-3495	158	13	)	)	PUNCT
dti-3495	158	14	,	,	PUNCT
dti-3495	158	15	keeping	keep	VERB
dti-3495	158	16	the	the	DET
dti-3495	158	17	interval	interval	NOUN
dti-3495	158	18	of	of	ADP
dti-3495	158	19	2	2	NUM
dti-3495	158	20	.	.	PUNCT
dti-3495	159	1	the	the	DET
dti-3495	159	2	various	various	ADJ
dti-3495	159	3	parameters	parameter	NOUN
dti-3495	159	4	that	that	PRON
dti-3495	159	5	were	be	AUX
dti-3495	159	6	assessed	assess	VERB
dti-3495	159	7	include	include	VERB
dti-3495	159	8	eel	eel	NOUN
dti-3495	159	9	(	(	PUNCT
dti-3495	159	10	electrostatic	electrostatic	ADJ
dti-3495	159	11	energy	energy	NOUN
dti-3495	159	12	)	)	PUNCT
dti-3495	159	13	,	,	PUNCT
dti-3495	159	14	esurf	esurf	NOUN
dti-3495	159	15	(	(	PUNCT
dti-3495	159	16	electrostatic	electrostatic	ADJ
dti-3495	159	17	surface	surface	NOUN
dti-3495	159	18	potential	potential	ADJ
dti-3495	159	19	energy	energy	NOUN
dti-3495	159	20	)	)	PUNCT
dti-3495	159	21	,	,	PUNCT
dti-3495	159	22	enpolar	enpolar	PROPN
dti-3495	159	23	(	(	PUNCT
dti-3495	159	24	polar	polar	ADJ
dti-3495	159	25	solvation	solvation	NOUN
dti-3495	159	26	energy	energy	NOUN
dti-3495	159	27	)	)	PUNCT
dti-3495	159	28	,	,	PUNCT
dti-3495	159	29	ggas	ggas	PROPN
dti-3495	159	30	,	,	PUNCT
dti-3495	159	31	van	van	PROPN
dti-3495	159	32	der	der	NOUN
dti-3495	159	33	waals	waal	NOUN
dti-3495	159	34	,	,	PUNCT
dti-3495	159	35	and	and	CCONJ
dti-3495	159	36	total	total	ADJ
dti-3495	159	37	energy	energy	NOUN
dti-3495	159	38	(	(	PUNCT
dti-3495	159	39	40	40	NUM
dti-3495	159	40	)	)	PUNCT
dti-3495	159	41	.	.	PUNCT
dti-3495	160	1	statistical	statistical	ADJ
dti-3495	160	2	analysis	analysis	NOUN
dti-3495	160	3	the	the	DET
dti-3495	160	4	experiments	experiment	NOUN
dti-3495	160	5	were	be	AUX
dti-3495	160	6	performed	perform	VERB
dti-3495	160	7	three	three	NUM
dti-3495	160	8	times	time	NOUN
dti-3495	160	9	,	,	PUNCT
dti-3495	160	10	and	and	CCONJ
dti-3495	160	11	the	the	DET
dti-3495	160	12	results	result	NOUN
dti-3495	160	13	are	be	AUX
dti-3495	160	14	presented	present	VERB
dti-3495	160	15	as	as	ADP
dti-3495	160	16	mean	mean	NOUN
dti-3495	160	17	±	±	NUM
dti-3495	160	18	standard	standard	ADJ
dti-3495	160	19	error	error	NOUN
dti-3495	160	20	of	of	ADP
dti-3495	160	21	the	the	DET
dti-3495	160	22	mean	mean	NOUN
dti-3495	160	23	.	.	PUNCT
dti-3495	161	1	the	the	DET
dti-3495	161	2	ic50	ic50	PROPN
dti-3495	161	3	values	value	NOUN
dti-3495	161	4	were	be	AUX
dti-3495	161	5	determined	determine	VERB
dti-3495	161	6	using	use	VERB
dti-3495	161	7	ibm	ibm	PROPN
dti-3495	161	8	spss	spss	PROPN
dti-3495	161	9	statistics	statistic	NOUN
dti-3495	161	10	21	21	NUM
dti-3495	161	11	software	software	NOUN
dti-3495	161	12	.	.	PUNCT
dti-3495	162	1	the	the	DET
dti-3495	162	2	data	datum	NOUN
dti-3495	162	3	underwent	undergo	VERB
dti-3495	162	4	analysis	analysis	NOUN
dti-3495	162	5	using	use	VERB
dti-3495	162	6	one	one	NUM
dti-3495	162	7	-	-	PUNCT
dti-3495	162	8	way	way	NOUN
dti-3495	162	9	anova	anova	PROPN
dti-3495	162	10	,	,	PUNCT
dti-3495	162	11	followed	follow	VERB
dti-3495	162	12	by	by	ADP
dti-3495	162	13	post	post	PROPN
dti-3495	162	14	hoc	hoc	X
dti-3495	162	15	dunnett	dunnett	PROPN
dti-3495	162	16	’s	’s	PART
dti-3495	162	17	multiple	multiple	ADJ
dti-3495	162	18	comparison	comparison	NOUN
dti-3495	162	19	test	test	NOUN
dti-3495	162	20	using	use	VERB
dti-3495	162	21	graphpad	graphpad	NOUN
dti-3495	162	22	prism	prism	NOUN
dti-3495	162	23	version	version	NOUN
dti-3495	162	24	8.0.2	8.0.2	NOUN
dti-3495	162	25	.	.	PUNCT
dti-3495	163	1	the	the	DET
dti-3495	163	2	criteria	criterion	NOUN
dti-3495	163	3	for	for	ADP
dti-3495	163	4	the	the	DET
dti-3495	163	5	statistical	statistical	ADJ
dti-3495	163	6	significance	significance	NOUN
dti-3495	163	7	were	be	AUX
dti-3495	163	8	chosen	choose	VERB
dti-3495	163	9	as	as	ADP
dti-3495	163	10	a	a	DET
dti-3495	163	11	p	p	NOUN
dti-3495	163	12	-	-	PUNCT
dti-3495	163	13	value	value	NOUN
dti-3495	163	14	less	less	ADJ
dti-3495	163	15	than	than	ADP
dti-3495	163	16	0.05	0.05	NUM
dti-3495	163	17	.	.	PUNCT
dti-3495	164	1	dunnett	dunnett	PROPN
dti-3495	164	2	’s	’s	PART
dti-3495	164	3	post	post	X
dti-3495	164	4	hoc	hoc	X
dti-3495	164	5	was	be	AUX
dti-3495	164	6	chosen	choose	VERB
dti-3495	164	7	because	because	SCONJ
dti-3495	164	8	it	it	PRON
dti-3495	164	9	adjusts	adjust	VERB
dti-3495	164	10	for	for	ADP
dti-3495	164	11	multiple	multiple	ADJ
dti-3495	164	12	comparisons	comparison	NOUN
dti-3495	164	13	inherently	inherently	ADV
dti-3495	164	14	and	and	CCONJ
dti-3495	164	15	tries	try	VERB
dti-3495	164	16	to	to	PART
dti-3495	164	17	ensure	ensure	VERB
dti-3495	164	18	the	the	DET
dti-3495	164	19	family	family	NOUN
dti-3495	164	20	-	-	PUNCT
dti-3495	164	21	wise	wise	ADJ
dti-3495	164	22	error	error	NOUN
dti-3495	164	23	rate	rate	NOUN
dti-3495	164	24	control	control	NOUN
dti-3495	164	25	during	during	ADP
dti-3495	164	26	multiple	multiple	ADJ
dti-3495	164	27	group	group	NOUN
dti-3495	164	28	comparisons	comparison	NOUN
dti-3495	164	29	with	with	ADP
dti-3495	164	30	a	a	DET
dti-3495	164	31	single	single	ADJ
dti-3495	164	32	control	control	NOUN
dti-3495	164	33	while	while	SCONJ
dti-3495	164	34	requiring	require	VERB
dti-3495	164	35	no	no	DET
dti-3495	164	36	additional	additional	ADJ
dti-3495	164	37	corrections	correction	NOUN
dti-3495	164	38	.	.	PUNCT
dti-3495	165	1	the	the	DET
dti-3495	165	2	effect	effect	NOUN
dti-3495	165	3	sizes	size	NOUN
dti-3495	165	4	were	be	AUX
dti-3495	165	5	applied	apply	VERB
dti-3495	165	6	to	to	ADP
dti-3495	165	7	all	all	DET
dti-3495	165	8	anova	anova	PROPN
dti-3495	165	9	calculations	calculation	NOUN
dti-3495	165	10	for	for	ADP
dti-3495	165	11	the	the	DET
dti-3495	165	12	magnitude	magnitude	NOUN
dti-3495	165	13	effects	effect	NOUN
dti-3495	165	14	quantifications	quantification	NOUN
dti-3495	165	15	.	.	PUNCT
dti-3495	166	1	the	the	DET
dti-3495	166	2	various	various	ADJ
dti-3495	166	3	tests	test	NOUN
dti-3495	166	4	applied	apply	VERB
dti-3495	166	5	include	include	VERB
dti-3495	166	6	the	the	DET
dti-3495	166	7	epsilon	epsilon	NOUN
dti-3495	166	8	-	-	PUNCT
dti-3495	166	9	squared	square	VERB
dti-3495	166	10	,	,	PUNCT
dti-3495	166	11	eta	eta	NOUN
dti-3495	166	12	-	-	PUNCT
dti-3495	166	13	squared	square	VERB
dti-3495	166	14	,	,	PUNCT
dti-3495	166	15	random	random	ADJ
dti-3495	166	16	-	-	PUNCT
dti-3495	166	17	effect	effect	NOUN
dti-3495	166	18	,	,	PUNCT
dti-3495	166	19	and	and	CCONJ
dti-3495	166	20	omega	omega	NOUN
dti-3495	166	21	-	-	PUNCT
dti-3495	166	22	squared	square	VERB
dti-3495	166	23	calculations	calculation	NOUN
dti-3495	166	24	with	with	ADP
dti-3495	166	25	confidence	confidence	NOUN
dti-3495	166	26	intervals	interval	NOUN
dti-3495	166	27	of	of	ADP
dti-3495	166	28	95	95	NUM
dti-3495	166	29	%	%	NOUN
dti-3495	166	30	to	to	PART
dti-3495	166	31	give	give	VERB
dti-3495	166	32	comprehensive	comprehensive	ADJ
dti-3495	166	33	insight	insight	NOUN
dti-3495	166	34	into	into	ADP
dti-3495	166	35	the	the	DET
dti-3495	166	36	magnitude	magnitude	NOUN
dti-3495	166	37	of	of	ADP
dti-3495	166	38	effect	effect	NOUN
dti-3495	166	39	.	.	PUNCT
dti-3495	167	1	results	result	VERB
dti-3495	167	2	α	α	PRON
dti-3495	167	3	-	-	PUNCT
dti-3495	167	4	amylase	amylase	NOUN
dti-3495	167	5	inhibitory	inhibitory	NOUN
dti-3495	167	6	assay	assay	AUX
dti-3495	167	7	the	the	DET
dti-3495	167	8	inhibitory	inhibitory	ADJ
dti-3495	167	9	efficacy	efficacy	NOUN
dti-3495	167	10	of	of	ADP
dti-3495	167	11	crude	crude	ADJ
dti-3495	167	12	hydro	hydro	NOUN
dti-3495	167	13	-	-	PUNCT
dti-3495	167	14	methanolic	methanolic	NOUN
dti-3495	167	15	extract	extract	NOUN
dti-3495	167	16	of	of	ADP
dti-3495	167	17	v.	v.	CCONJ
dti-3495	167	18	unguiculata	unguiculata	PROPN
dti-3495	167	19	and	and	CCONJ
dti-3495	167	20	its	its	PRON
dti-3495	167	21	fractions	fraction	NOUN
dti-3495	167	22	against	against	ADP
dti-3495	167	23	α	α	NOUN
dti-3495	167	24	-	-	PUNCT
dti-3495	167	25	amylase	amylase	NOUN
dti-3495	167	26	enzyme	enzyme	NOUN
dti-3495	167	27	was	be	AUX
dti-3495	167	28	investigated	investigate	VERB
dti-3495	167	29	using	use	VERB
dti-3495	167	30	in	in	ADP
dti-3495	167	31	vitro	vitro	X
dti-3495	167	32	activity	activity	NOUN
dti-3495	167	33	.	.	PUNCT
dti-3495	168	1	various	various	ADJ
dti-3495	168	2	concentrations	concentration	NOUN
dti-3495	168	3	,	,	PUNCT
dti-3495	168	4	including	include	VERB
dti-3495	168	5	8	8	NUM
dti-3495	168	6	,	,	PUNCT
dti-3495	168	7	4	4	NUM
dti-3495	168	8	,	,	PUNCT
dti-3495	168	9	2	2	NUM
dti-3495	168	10	,	,	PUNCT
dti-3495	168	11	1	1	NUM
dti-3495	168	12	,	,	PUNCT
dti-3495	168	13	0.5	0.5	NUM
dti-3495	168	14	,	,	PUNCT
dti-3495	168	15	0.25	0.25	NUM
dti-3495	168	16	,	,	PUNCT
dti-3495	168	17	0.125	0.125	NUM
dti-3495	168	18	,	,	PUNCT
dti-3495	168	19	0.0625	0.0625	NUM
dti-3495	168	20	,	,	PUNCT
dti-3495	168	21	and	and	CCONJ
dti-3495	168	22	0.03125	0.03125	NUM
dti-3495	168	23	mg	mg	NUM
dti-3495	168	24	/	/	SYM
dti-3495	168	25	ml	ml	NOUN
dti-3495	168	26	,	,	PUNCT
dti-3495	168	27	were	be	AUX
dti-3495	168	28	used	use	VERB
dti-3495	168	29	to	to	PART
dti-3495	168	30	test	test	VERB
dti-3495	168	31	the	the	DET
dti-3495	168	32	samples	sample	NOUN
dti-3495	168	33	and	and	CCONJ
dti-3495	168	34	determine	determine	VERB
dti-3495	168	35	their	their	PRON
dti-3495	168	36	ic50	ic50	PROPN
dti-3495	168	37	values	value	NOUN
dti-3495	168	38	.	.	PUNCT
dti-3495	169	1	the	the	DET
dti-3495	169	2	crude	crude	ADJ
dti-3495	169	3	extract	extract	NOUN
dti-3495	169	4	exhibited	exhibit	VERB
dti-3495	169	5	a	a	DET
dti-3495	169	6	significantly	significantly	ADV
dti-3495	169	7	lower	low	ADJ
dti-3495	169	8	ic50	ic50	PROPN
dti-3495	169	9	value	value	NOUN
dti-3495	169	10	of	of	ADP
dti-3495	169	11	0.202	0.202	NUM
dti-3495	169	12	mg	mg	NOUN
dti-3495	169	13	/	/	SYM
dti-3495	169	14	ml	ml	PROPN
dti-3495	169	15	compared	compare	VERB
dti-3495	169	16	to	to	ADP
dti-3495	169	17	the	the	DET
dti-3495	169	18	aqueous	aqueous	ADJ
dti-3495	169	19	(	(	PUNCT
dti-3495	169	20	0.279	0.279	NUM
dti-3495	169	21	mg	mg	PROPN
dti-3495	169	22	/	/	SYM
dti-3495	169	23	ml	ml	NOUN
dti-3495	169	24	)	)	PUNCT
dti-3495	169	25	,	,	PUNCT
dti-3495	169	26	ethyl	ethyl	PROPN
dti-3495	169	27	acetate	acetate	PROPN
dti-3495	169	28	(	(	PUNCT
dti-3495	169	29	0.557	0.557	NUM
dti-3495	169	30	mg	mg	NUM
dti-3495	169	31	/	/	SYM
dti-3495	169	32	ml	ml	NOUN
dti-3495	169	33	)	)	PUNCT
dti-3495	169	34	,	,	PUNCT
dti-3495	169	35	and	and	CCONJ
dti-3495	169	36	n	n	CCONJ
dti-3495	169	37	-	-	PUNCT
dti-3495	169	38	hexane	hexane	NOUN
dti-3495	169	39	(	(	PUNCT
dti-3495	169	40	1.294	1.294	NUM
dti-3495	169	41	mg	mg	NUM
dti-3495	169	42	/	/	SYM
dti-3495	169	43	ml	ml	NOUN
dti-3495	169	44	)	)	PUNCT
dti-3495	169	45	fractions	fraction	NOUN
dti-3495	169	46	.	.	PUNCT
dti-3495	170	1	in	in	ADP
dti-3495	170	2	comparison	comparison	NOUN
dti-3495	170	3	,	,	PUNCT
dti-3495	170	4	acarbose	acarbose	NOUN
dti-3495	170	5	,	,	PUNCT
dti-3495	170	6	used	use	VERB
dti-3495	170	7	as	as	ADP
dti-3495	170	8	the	the	DET
dti-3495	170	9	standard	standard	NOUN
dti-3495	170	10	,	,	PUNCT
dti-3495	170	11	demonstrated	demonstrate	VERB
dti-3495	170	12	the	the	DET
dti-3495	170	13	highest	high	ADJ
dti-3495	170	14	inhibition	inhibition	NOUN
dti-3495	170	15	of	of	ADP
dti-3495	170	16	the	the	DET
dti-3495	170	17	alpha	alpha	NOUN
dti-3495	170	18	amylase	amylase	NOUN
dti-3495	170	19	enzyme	enzyme	NOUN
dti-3495	170	20	with	with	ADP
dti-3495	170	21	an	an	DET
dti-3495	170	22	ic50	ic50	PROPN
dti-3495	170	23	value	value	NOUN
dti-3495	170	24	of	of	ADP
dti-3495	170	25	0.043	0.043	NUM
dti-3495	170	26	mg	mg	PROPN
dti-3495	170	27	/	/	SYM
dti-3495	170	28	ml	ml	NOUN
dti-3495	170	29	,	,	PUNCT
dti-3495	170	30	as	as	SCONJ
dti-3495	170	31	depicted	depict	VERB
dti-3495	170	32	in	in	ADP
dti-3495	170	33	figure	figure	NOUN
dti-3495	170	34	1	1	NUM
dti-3495	170	35	.	.	PUNCT
dti-3495	170	36	α	α	X
dti-3495	170	37	-	-	PUNCT
dti-3495	170	38	glucosidase	glucosidase	ADJ
dti-3495	170	39	inhibitory	inhibitory	NOUN
dti-3495	170	40	assay	assay	VERB
dti-3495	170	41	the	the	DET
dti-3495	170	42	inhibitory	inhibitory	ADJ
dti-3495	170	43	potential	potential	NOUN
dti-3495	170	44	against	against	ADP
dti-3495	170	45	α	α	NOUN
dti-3495	170	46	-	-	PUNCT
dti-3495	170	47	glucosidase	glucosidase	ADJ
dti-3495	170	48	enzyme	enzyme	NOUN
dti-3495	170	49	using	use	VERB
dti-3495	170	50	in	in	ADP
dti-3495	170	51	vitro	vitro	X
dti-3495	170	52	activity	activity	NOUN
dti-3495	170	53	was	be	AUX
dti-3495	170	54	examined	examine	VERB
dti-3495	170	55	on	on	ADP
dti-3495	170	56	the	the	DET
dti-3495	170	57	crude	crude	ADJ
dti-3495	170	58	hydromethanolic	hydromethanolic	ADJ
dti-3495	170	59	extract	extract	NOUN
dti-3495	170	60	of	of	ADP
dti-3495	170	61	v.	v.	CCONJ
dti-3495	170	62	unguiculata	unguiculata	PROPN
dti-3495	170	63	and	and	CCONJ
dti-3495	170	64	its	its	PRON
dti-3495	170	65	fractions	fraction	NOUN
dti-3495	170	66	.	.	PUNCT
dti-3495	171	1	various	various	ADJ
dti-3495	171	2	concentrations	concentration	NOUN
dti-3495	171	3	,	,	PUNCT
dti-3495	171	4	including	include	VERB
dti-3495	171	5	8	8	NUM
dti-3495	171	6	,	,	PUNCT
dti-3495	171	7	4	4	NUM
dti-3495	171	8	,	,	PUNCT
dti-3495	171	9	2	2	NUM
dti-3495	171	10	,	,	PUNCT
dti-3495	171	11	1	1	NUM
dti-3495	171	12	,	,	PUNCT
dti-3495	171	13	0.5	0.5	NUM
dti-3495	171	14	,	,	PUNCT
dti-3495	171	15	0.25	0.25	NUM
dti-3495	171	16	,	,	PUNCT
dti-3495	171	17	0.125	0.125	NUM
dti-3495	171	18	,	,	PUNCT
dti-3495	171	19	and	and	CCONJ
dti-3495	171	20	0.0625	0.0625	NUM
dti-3495	171	21	mg	mg	NUM
dti-3495	171	22	/	/	SYM
dti-3495	171	23	ml	ml	NOUN
dti-3495	171	24	,	,	PUNCT
dti-3495	171	25	were	be	AUX
dti-3495	171	26	used	use	VERB
dti-3495	171	27	to	to	PART
dti-3495	171	28	test	test	VERB
dti-3495	171	29	the	the	DET
dti-3495	171	30	samples	sample	NOUN
dti-3495	171	31	,	,	PUNCT
dti-3495	171	32	and	and	CCONJ
dti-3495	171	33	their	their	PRON
dti-3495	171	34	ic50	ic50	PROPN
dti-3495	171	35	values	value	NOUN
dti-3495	171	36	were	be	AUX
dti-3495	171	37	determined	determine	VERB
dti-3495	171	38	.	.	PUNCT
dti-3495	172	1	the	the	DET
dti-3495	172	2	crude	crude	ADJ
dti-3495	172	3	extract	extract	NOUN
dti-3495	172	4	displayed	display	VERB
dti-3495	172	5	a	a	DET
dti-3495	172	6	significantly	significantly	ADV
dti-3495	172	7	lower	low	ADJ
dti-3495	172	8	ic50	ic50	PROPN
dti-3495	172	9	value	value	NOUN
dti-3495	172	10	(	(	PUNCT
dti-3495	172	11	0.111	0.111	NUM
dti-3495	172	12	mg	mg	PROPN
dti-3495	172	13	/	/	SYM
dti-3495	172	14	ml	ml	NOUN
dti-3495	172	15	)	)	PUNCT
dti-3495	172	16	compared	compare	VERB
dti-3495	172	17	to	to	ADP
dti-3495	172	18	the	the	DET
dti-3495	172	19	ethyl	ethyl	PROPN
dti-3495	172	20	acetate	acetate	NOUN
dti-3495	172	21	(	(	PUNCT
dti-3495	172	22	0.135	0.135	NUM
dti-3495	172	23	mg	mg	NUM
dti-3495	172	24	/	/	SYM
dti-3495	172	25	ml	ml	NOUN
dti-3495	172	26	)	)	PUNCT
dti-3495	172	27	,	,	PUNCT
dti-3495	172	28	aqueous	aqueous	ADJ
dti-3495	172	29	(	(	PUNCT
dti-3495	172	30	0.243	0.243	NUM
dti-3495	172	31	mg	mg	PROPN
dti-3495	172	32	/	/	SYM
dti-3495	172	33	ml	ml	NOUN
dti-3495	172	34	)	)	PUNCT
dti-3495	172	35	,	,	PUNCT
dti-3495	172	36	and	and	CCONJ
dti-3495	172	37	n	n	CCONJ
dti-3495	172	38	-	-	PUNCT
dti-3495	172	39	hexane	hexane	NOUN
dti-3495	172	40	(	(	PUNCT
dti-3495	172	41	0.629	0.629	NUM
dti-3495	172	42	mg	mg	PROPN
dti-3495	172	43	/	/	SYM
dti-3495	172	44	ml	ml	NOUN
dti-3495	172	45	)	)	PUNCT
dti-3495	172	46	fractions	fraction	NOUN
dti-3495	172	47	among	among	ADP
dti-3495	172	48	all	all	DET
dti-3495	172	49	the	the	DET
dti-3495	172	50	tested	test	VERB
dti-3495	172	51	samples	sample	NOUN
dti-3495	172	52	.	.	PUNCT
dti-3495	173	1	acarbose	acarbose	NOUN
dti-3495	173	2	,	,	PUNCT
dti-3495	173	3	used	use	VERB
dti-3495	173	4	as	as	ADP
dti-3495	173	5	the	the	DET
dti-3495	173	6	standard	standard	NOUN
dti-3495	173	7	,	,	PUNCT
dti-3495	173	8	exhibited	exhibit	VERB
dti-3495	173	9	the	the	DET
dti-3495	173	10	highest	high	ADJ
dti-3495	173	11	figure	figure	NOUN
dti-3495	173	12	1	1	NUM
dti-3495	173	13	representing	represent	VERB
dti-3495	173	14	alpha	alpha	NOUN
dti-3495	173	15	amylase	amylase	NOUN
dti-3495	173	16	inhibitory	inhibitory	ADJ
dti-3495	173	17	activity	activity	NOUN
dti-3495	173	18	of	of	ADP
dti-3495	173	19	(	(	PUNCT
dti-3495	173	20	a	a	PRON
dti-3495	173	21	)	)	PUNCT
dti-3495	173	22	crude	crude	ADJ
dti-3495	173	23	extract	extract	NOUN
dti-3495	173	24	,	,	PUNCT
dti-3495	173	25	(	(	PUNCT
dti-3495	173	26	b	b	X
dti-3495	173	27	)	)	PUNCT
dti-3495	173	28	aqueous	aqueous	ADJ
dti-3495	173	29	fraction	fraction	NOUN
dti-3495	173	30	,	,	PUNCT
dti-3495	173	31	(	(	PUNCT
dti-3495	173	32	c	c	X
dti-3495	173	33	)	)	PUNCT
dti-3495	173	34	ethyl	ethyl	PROPN
dti-3495	173	35	acetate	acetate	PROPN
dti-3495	173	36	fraction	fraction	PROPN
dti-3495	173	37	,	,	PUNCT
dti-3495	173	38	(	(	PUNCT
dti-3495	173	39	d	d	NOUN
dti-3495	173	40	)	)	PUNCT
dti-3495	173	41	n	n	CCONJ
dti-3495	173	42	-	-	PUNCT
dti-3495	173	43	hexane	hexane	NOUN
dti-3495	173	44	fraction	fraction	NOUN
dti-3495	173	45	,	,	PUNCT
dti-3495	173	46	and	and	CCONJ
dti-3495	173	47	(	(	PUNCT
dti-3495	173	48	e	e	NOUN
dti-3495	173	49	)	)	PUNCT
dti-3495	173	50	standard	standard	ADJ
dti-3495	173	51	drug	drug	NOUN
dti-3495	173	52	,	,	PUNCT
dti-3495	173	53	acarbose	acarbose	NOUN
dti-3495	173	54	.	.	PUNCT
dti-3495	174	1	in	in	ADP
dti-3495	174	2	silico	silico	NOUN
dti-3495	174	3	anti	anti	ADJ
dti-3495	174	4	-	-	ADJ
dti-3495	174	5	diabetic	diabetic	ADJ
dti-3495	174	6	potential	potential	NOUN
dti-3495	174	7	of	of	ADP
dti-3495	174	8	vigna	vigna	PROPN
dti-3495	174	9	unguiculata76	unguiculata76	PROPN
dti-3495	175	1	©	©	PROPN
dti-3495	175	2	2025	2025	NUM
dti-3495	175	3	the	the	DET
dti-3495	175	4	authors	author	NOUN
dti-3495	175	5	.	.	PUNCT
dti-3495	176	1	drug	drug	NOUN
dti-3495	176	2	target	target	NOUN
dti-3495	176	3	insights	insight	NOUN
dti-3495	176	4	issn	issn	VERB
dti-3495	176	5	1177	1177	NUM
dti-3495	176	6	-	-	SYM
dti-3495	176	7	3928	3928	NUM
dti-3495	176	8	www.aboutscience.eu/dti	www.aboutscience.eu/dti	NOUN
dti-3495	176	9	inhibition	inhibition	NOUN
dti-3495	176	10	of	of	ADP
dti-3495	176	11	alpha	alpha	ADJ
dti-3495	176	12	amylase	amylase	NOUN
dti-3495	176	13	enzyme	enzyme	NOUN
dti-3495	176	14	with	with	ADP
dti-3495	176	15	an	an	DET
dti-3495	176	16	ic50	ic50	PROPN
dti-3495	176	17	value	value	NOUN
dti-3495	176	18	of	of	ADP
dti-3495	176	19	0.034	0.034	NUM
dti-3495	176	20	mg	mg	PROPN
dti-3495	176	21	/	/	SYM
dti-3495	176	22	ml	ml	NOUN
dti-3495	176	23	,	,	PUNCT
dti-3495	176	24	as	as	SCONJ
dti-3495	176	25	depicted	depict	VERB
dti-3495	176	26	in	in	ADP
dti-3495	176	27	figure	figure	NOUN
dti-3495	176	28	2	2	NUM
dti-3495	176	29	.	.	PUNCT
dti-3495	176	30	aldose	aldose	PROPN
dti-3495	176	31	reductase	reductase	NOUN
dti-3495	176	32	inhibitory	inhibitory	ADJ
dti-3495	176	33	assay	assay	PROPN
dti-3495	176	34	v.	v.	PROPN
dti-3495	176	35	unguiculata	unguiculata	ADJ
dti-3495	176	36	crude	crude	ADJ
dti-3495	176	37	hydro	hydro	PROPN
dti-3495	176	38	-	-	PUNCT
dti-3495	176	39	methanolic	methanolic	NOUN
dti-3495	176	40	extract	extract	NOUN
dti-3495	176	41	and	and	CCONJ
dti-3495	176	42	its	its	PRON
dti-3495	176	43	fractions	fraction	NOUN
dti-3495	176	44	were	be	AUX
dti-3495	176	45	examined	examine	VERB
dti-3495	176	46	for	for	ADP
dti-3495	176	47	their	their	PRON
dti-3495	176	48	ability	ability	NOUN
dti-3495	176	49	to	to	PART
dti-3495	176	50	inhibit	inhibit	VERB
dti-3495	176	51	aldose	aldose	DET
dti-3495	176	52	reductase	reductase	NOUN
dti-3495	176	53	enzyme	enzyme	NOUN
dti-3495	176	54	through	through	ADP
dti-3495	176	55	an	an	DET
dti-3495	176	56	in	in	X
dti-3495	176	57	vitro	vitro	X
dti-3495	176	58	assay	assay	NOUN
dti-3495	176	59	.	.	PUNCT
dti-3495	177	1	various	various	ADJ
dti-3495	177	2	figure	figure	NOUN
dti-3495	177	3	2	2	NUM
dti-3495	177	4	representing	represent	VERB
dti-3495	177	5	α	α	NOUN
dti-3495	177	6	glucosidase	glucosidase	ADJ
dti-3495	177	7	inhibitory	inhibitory	ADJ
dti-3495	177	8	activity	activity	NOUN
dti-3495	177	9	of	of	ADP
dti-3495	177	10	(	(	PUNCT
dti-3495	177	11	a	a	PRON
dti-3495	177	12	)	)	PUNCT
dti-3495	177	13	crude	crude	ADJ
dti-3495	177	14	extract	extract	NOUN
dti-3495	177	15	,	,	PUNCT
dti-3495	177	16	(	(	PUNCT
dti-3495	177	17	b	b	X
dti-3495	177	18	)	)	PUNCT
dti-3495	177	19	ethyl	ethyl	PROPN
dti-3495	177	20	acetate	acetate	PROPN
dti-3495	177	21	fraction	fraction	PROPN
dti-3495	177	22	,	,	PUNCT
dti-3495	177	23	(	(	PUNCT
dti-3495	177	24	c	c	NOUN
dti-3495	177	25	)	)	PUNCT
dti-3495	177	26	aqueous	aqueous	ADJ
dti-3495	177	27	fraction	fraction	NOUN
dti-3495	177	28	,	,	PUNCT
dti-3495	177	29	(	(	PUNCT
dti-3495	177	30	d	d	NOUN
dti-3495	177	31	)	)	PUNCT
dti-3495	177	32	n	n	CCONJ
dti-3495	177	33	-	-	PUNCT
dti-3495	177	34	hexane	hexane	NOUN
dti-3495	177	35	fraction	fraction	NOUN
dti-3495	177	36	,	,	PUNCT
dti-3495	177	37	and	and	CCONJ
dti-3495	177	38	(	(	PUNCT
dti-3495	177	39	e	e	NOUN
dti-3495	177	40	)	)	PUNCT
dti-3495	177	41	standard	standard	ADJ
dti-3495	177	42	drug	drug	NOUN
dti-3495	177	43	,	,	PUNCT
dti-3495	177	44	acarbose	acarbose	NOUN
dti-3495	177	45	.	.	PUNCT
dti-3495	178	1	concentrations	concentration	NOUN
dti-3495	178	2	,	,	PUNCT
dti-3495	178	3	including	include	VERB
dti-3495	178	4	300	300	NUM
dti-3495	178	5	,	,	PUNCT
dti-3495	178	6	200	200	NUM
dti-3495	178	7	,	,	PUNCT
dti-3495	178	8	100	100	NUM
dti-3495	178	9	,	,	PUNCT
dti-3495	178	10	50	50	NUM
dti-3495	178	11	,	,	PUNCT
dti-3495	178	12	25	25	NUM
dti-3495	178	13	,	,	PUNCT
dti-3495	178	14	and	and	CCONJ
dti-3495	178	15	10	10	NUM
dti-3495	178	16	µg	µg	NOUN
dti-3495	178	17	/	/	SYM
dti-3495	178	18	ml	ml	NOUN
dti-3495	178	19	,	,	PUNCT
dti-3495	178	20	were	be	AUX
dti-3495	178	21	tested	test	VERB
dti-3495	178	22	,	,	PUNCT
dti-3495	178	23	and	and	CCONJ
dti-3495	178	24	the	the	DET
dti-3495	178	25	ic50	ic50	PROPN
dti-3495	178	26	values	value	NOUN
dti-3495	178	27	were	be	AUX
dti-3495	178	28	determined	determine	VERB
dti-3495	178	29	.	.	PUNCT
dti-3495	179	1	the	the	DET
dti-3495	179	2	crude	crude	ADJ
dti-3495	179	3	extract	extract	NOUN
dti-3495	179	4	displayed	display	VERB
dti-3495	179	5	the	the	DET
dti-3495	179	6	lowest	low	ADJ
dti-3495	179	7	ic50	ic50	PROPN
dti-3495	179	8	value	value	NOUN
dti-3495	179	9	(	(	PUNCT
dti-3495	179	10	15.823	15.823	NUM
dti-3495	179	11	µg	µg	NOUN
dti-3495	179	12	/	/	SYM
dti-3495	179	13	ml	ml	NOUN
dti-3495	179	14	)	)	PUNCT
dti-3495	179	15	among	among	ADP
dti-3495	179	16	all	all	DET
dti-3495	179	17	the	the	DET
dti-3495	179	18	samples	sample	NOUN
dti-3495	179	19	tested	test	VERB
dti-3495	179	20	,	,	PUNCT
dti-3495	179	21	followed	follow	VERB
dti-3495	179	22	by	by	ADP
dti-3495	179	23	ethyl	ethyl	PROPN
dti-3495	179	24	acetate	acetate	PROPN
dti-3495	179	25	(	(	PUNCT
dti-3495	179	26	25.806	25.806	NUM
dti-3495	179	27	µg	µg	ADV
dti-3495	179	28	/ml	/ml	NUM
dti-3495	179	29	)	)	PUNCT
dti-3495	179	30	,	,	PUNCT
dti-3495	179	31	aqueous	aqueous	ADJ
dti-3495	179	32	(	(	PUNCT
dti-3495	179	33	52.376	52.376	NUM
dti-3495	179	34	µg	µg	ADV
dti-3495	179	35	/ml	/ml	NUM
dti-3495	179	36	)	)	PUNCT
dti-3495	179	37	,	,	PUNCT
dti-3495	179	38	and	and	CCONJ
dti-3495	179	39	n	n	CCONJ
dti-3495	179	40	-	-	PUNCT
dti-3495	179	41	hexane	hexane	NOUN
dti-3495	179	42	(	(	PUNCT
dti-3495	179	43	106.857	106.857	NUM
dti-3495	179	44	µg	µg	ADP
dti-3495	179	45	/ml	/ml	NOUN
dti-3495	179	46	)	)	PUNCT
dti-3495	179	47	fractions	fraction	NOUN
dti-3495	179	48	.	.	PUNCT
dti-3495	180	1	quercetin	quercetin	NOUN
dti-3495	180	2	,	,	PUNCT
dti-3495	180	3	used	use	VERB
dti-3495	180	4	as	as	ADP
dti-3495	180	5	the	the	DET
dti-3495	180	6	standard	standard	NOUN
dti-3495	180	7	,	,	PUNCT
dti-3495	180	8	exhibited	exhibit	VERB
dti-3495	180	9	the	the	DET
dti-3495	180	10	highest	high	ADJ
dti-3495	180	11	inhibition	inhibition	NOUN
dti-3495	180	12	of	of	ADP
dti-3495	180	13	alpha	alpha	ADJ
dti-3495	180	14	amylase	amylase	NOUN
dti-3495	180	15	enzyme	enzyme	NOUN
dti-3495	180	16	with	with	ADP
dti-3495	180	17	an	an	DET
dti-3495	180	18	ic50	ic50	PROPN
dti-3495	180	19	value	value	NOUN
dti-3495	180	20	of	of	ADP
dti-3495	180	21	8.545	8.545	NUM
dti-3495	180	22	µg	µg	ADP
dti-3495	180	23	/ml	/ml	PRON
dti-3495	180	24	,	,	PUNCT
dti-3495	180	25	as	as	SCONJ
dti-3495	180	26	indicated	indicate	VERB
dti-3495	180	27	in	in	ADP
dti-3495	180	28	figure	figure	NOUN
dti-3495	180	29	3	3	NUM
dti-3495	180	30	.	.	PUNCT
dti-3495	180	31	figure	figure	VERB
dti-3495	180	32	3	3	NUM
dti-3495	180	33	representing	represent	VERB
dti-3495	180	34	aldose	aldose	PRON
dti-3495	180	35	reductase	reductase	NOUN
dti-3495	180	36	inhibitory	inhibitory	ADJ
dti-3495	180	37	activity	activity	NOUN
dti-3495	180	38	of	of	ADP
dti-3495	180	39	(	(	PUNCT
dti-3495	180	40	a	a	PRON
dti-3495	180	41	)	)	PUNCT
dti-3495	180	42	crude	crude	ADJ
dti-3495	180	43	extract	extract	NOUN
dti-3495	180	44	,	,	PUNCT
dti-3495	180	45	(	(	PUNCT
dti-3495	180	46	b	b	X
dti-3495	180	47	)	)	PUNCT
dti-3495	180	48	ethyl	ethyl	PROPN
dti-3495	180	49	acetate	acetate	PROPN
dti-3495	180	50	fraction	fraction	PROPN
dti-3495	180	51	,	,	PUNCT
dti-3495	180	52	(	(	PUNCT
dti-3495	180	53	c	c	NOUN
dti-3495	180	54	)	)	PUNCT
dti-3495	180	55	aqueous	aqueous	ADJ
dti-3495	180	56	fraction	fraction	NOUN
dti-3495	180	57	,	,	PUNCT
dti-3495	180	58	(	(	PUNCT
dti-3495	180	59	d	d	NOUN
dti-3495	180	60	)	)	PUNCT
dti-3495	180	61	n	n	CCONJ
dti-3495	180	62	-	-	PUNCT
dti-3495	180	63	hexane	hexane	NOUN
dti-3495	180	64	fraction	fraction	NOUN
dti-3495	180	65	,	,	PUNCT
dti-3495	180	66	and	and	CCONJ
dti-3495	180	67	(	(	PUNCT
dti-3495	180	68	e	e	NOUN
dti-3495	180	69	)	)	PUNCT
dti-3495	180	70	standard	standard	ADJ
dti-3495	180	71	drug	drug	NOUN
dti-3495	180	72	,	,	PUNCT
dti-3495	180	73	quercetin	quercetin	NOUN
dti-3495	180	74	.	.	PUNCT
dti-3495	181	1	sardar	sardar	PROPN
dti-3495	181	2	et	et	PROPN
dti-3495	181	3	al	al	PROPN
dti-3495	181	4	drug	drug	PROPN
dti-3495	181	5	target	target	NOUN
dti-3495	181	6	insights	insight	NOUN
dti-3495	181	7	2025	2025	NUM
dti-3495	181	8	;	;	PUNCT
dti-3495	181	9	19	19	NUM
dti-3495	181	10	:	:	SYM
dti-3495	181	11	77	77	NUM
dti-3495	181	12	©	©	PROPN
dti-3495	181	13	2025	2025	NUM
dti-3495	181	14	the	the	DET
dti-3495	181	15	authors	author	NOUN
dti-3495	181	16	.	.	PUNCT
dti-3495	182	1	published	publish	VERB
dti-3495	182	2	by	by	ADP
dti-3495	182	3	aboutscience	aboutscience	NOUN
dti-3495	182	4	www.aboutscience.eu	www.aboutscience.eu	NOUN
dti-3495	182	5	network	network	NOUN
dti-3495	182	6	pharmacology	pharmacology	NOUN
dti-3495	182	7	screening	screening	NOUN
dti-3495	182	8	of	of	ADP
dti-3495	182	9	potential	potential	ADJ
dti-3495	182	10	compounds	compound	VERB
dti-3495	182	11	the	the	DET
dti-3495	182	12	screening	screening	NOUN
dti-3495	182	13	of	of	ADP
dti-3495	182	14	potential	potential	ADJ
dti-3495	182	15	compounds	compound	NOUN
dti-3495	182	16	from	from	ADP
dti-3495	182	17	v.	v.	ADP
dti-3495	182	18	unguiculata	unguiculata	PROPN
dti-3495	182	19	identified	identify	VERB
dti-3495	182	20	several	several	ADJ
dti-3495	182	21	candidates	candidate	NOUN
dti-3495	182	22	with	with	ADP
dti-3495	182	23	drug	drug	NOUN
dti-3495	182	24	-	-	PUNCT
dti-3495	182	25	like	like	ADJ
dti-3495	182	26	potential	potential	NOUN
dti-3495	182	27	,	,	PUNCT
dti-3495	182	28	as	as	SCONJ
dti-3495	182	29	summarized	summarize	VERB
dti-3495	182	30	in	in	ADP
dti-3495	182	31	table	table	NOUN
dti-3495	182	32	1	1	NUM
dti-3495	182	33	.	.	PUNCT
dti-3495	183	1	the	the	DET
dti-3495	183	2	compounds	compound	NOUN
dti-3495	183	3	belong	belong	VERB
dti-3495	183	4	to	to	ADP
dti-3495	183	5	various	various	ADJ
dti-3495	183	6	classes	class	NOUN
dti-3495	183	7	,	,	PUNCT
dti-3495	183	8	including	include	VERB
dti-3495	183	9	flavonoids	flavonoid	NOUN
dti-3495	183	10	,	,	PUNCT
dti-3495	183	11	phenolic	phenolic	ADJ
dti-3495	183	12	acids	acid	NOUN
dti-3495	183	13	,	,	PUNCT
dti-3495	183	14	isoflavones	isoflavone	NOUN
dti-3495	183	15	,	,	PUNCT
dti-3495	183	16	triterpenoids	triterpenoids	PROPN
dti-3495	183	17	,	,	PUNCT
dti-3495	183	18	phytosterols	phytosterol	NOUN
dti-3495	183	19	,	,	PUNCT
dti-3495	183	20	and	and	CCONJ
dti-3495	183	21	alkaloids	alkaloid	NOUN
dti-3495	183	22	,	,	PUNCT
dti-3495	183	23	each	each	PRON
dti-3495	183	24	exhibiting	exhibit	VERB
dti-3495	183	25	different	different	ADJ
dti-3495	183	26	molecular	molecular	ADJ
dti-3495	183	27	weights	weight	NOUN
dti-3495	183	28	,	,	PUNCT
dti-3495	183	29	drug	drug	NOUN
dti-3495	183	30	likeness	likeness	NOUN
dti-3495	183	31	(	(	PUNCT
dti-3495	183	32	dl	dl	NOUN
dti-3495	183	33	)	)	PUNCT
dti-3495	183	34	,	,	PUNCT
dti-3495	183	35	and	and	CCONJ
dti-3495	183	36	oral	oral	ADJ
dti-3495	183	37	bioavailability	bioavailability	NOUN
dti-3495	183	38	(	(	PUNCT
dti-3495	183	39	ob	ob	NOUN
dti-3495	183	40	)	)	PUNCT
dti-3495	183	41	.	.	PUNCT
dti-3495	184	1	among	among	ADP
dti-3495	184	2	the	the	DET
dti-3495	184	3	flavonoids	flavonoid	NOUN
dti-3495	184	4	,	,	PUNCT
dti-3495	184	5	quercetin	quercetin	NOUN
dti-3495	184	6	,	,	PUNCT
dti-3495	184	7	kaempferol	kaempferol	NOUN
dti-3495	184	8	,	,	PUNCT
dti-3495	184	9	catechin	catechin	NOUN
dti-3495	184	10	,	,	PUNCT
dti-3495	184	11	luteolin	luteolin	PROPN
dti-3495	184	12	,	,	PUNCT
dti-3495	184	13	and	and	CCONJ
dti-3495	184	14	apigenin	apigenin	PROPN
dti-3495	184	15	were	be	AUX
dti-3495	184	16	identified	identify	VERB
dti-3495	184	17	,	,	PUNCT
dti-3495	184	18	with	with	ADP
dti-3495	184	19	molecular	molecular	ADJ
dti-3495	184	20	weights	weight	NOUN
dti-3495	184	21	ranging	range	VERB
dti-3495	184	22	from	from	ADP
dti-3495	184	23	270.24	270.24	NUM
dti-3495	184	24	to	to	ADP
dti-3495	184	25	302.23	302.23	NUM
dti-3495	184	26	g	g	NOUN
dti-3495	184	27	/	/	SYM
dti-3495	184	28	mol	mol	NOUN
dti-3495	184	29	.	.	PUNCT
dti-3495	185	1	these	these	DET
dti-3495	185	2	compounds	compound	NOUN
dti-3495	185	3	showed	show	VERB
dti-3495	185	4	moderate	moderate	ADJ
dti-3495	185	5	drug	drug	NOUN
dti-3495	185	6	likeness	likeness	NOUN
dti-3495	185	7	scores	score	NOUN
dti-3495	185	8	,	,	PUNCT
dti-3495	185	9	with	with	ADP
dti-3495	185	10	catechin	catechin	NOUN
dti-3495	185	11	having	have	VERB
dti-3495	185	12	the	the	DET
dti-3495	185	13	highest	high	ADJ
dti-3495	185	14	dl	dl	NOUN
dti-3495	185	15	of	of	ADP
dti-3495	185	16	0.64	0.64	NUM
dti-3495	185	17	,	,	PUNCT
dti-3495	185	18	and	and	CCONJ
dti-3495	185	19	all	all	PRON
dti-3495	185	20	of	of	ADP
dti-3495	185	21	them	they	PRON
dti-3495	185	22	exhibited	exhibit	VERB
dti-3495	185	23	an	an	DET
dti-3495	185	24	oral	oral	ADJ
dti-3495	185	25	bioavailability	bioavailability	NOUN
dti-3495	185	26	of	of	ADP
dti-3495	185	27	0.55	0.55	NUM
dti-3495	185	28	,	,	PUNCT
dti-3495	185	29	indicating	indicate	VERB
dti-3495	185	30	their	their	PRON
dti-3495	185	31	potential	potential	NOUN
dti-3495	185	32	for	for	ADP
dti-3495	185	33	oral	oral	ADJ
dti-3495	185	34	administration	administration	NOUN
dti-3495	185	35	.	.	PUNCT
dti-3495	186	1	protocatechuic	protocatechuic	PROPN
dti-3495	186	2	acid	acid	PROPN
dti-3495	186	3	,	,	PUNCT
dti-3495	186	4	a	a	DET
dti-3495	186	5	phenolic	phenolic	ADJ
dti-3495	186	6	acid	acid	NOUN
dti-3495	186	7	with	with	ADP
dti-3495	186	8	a	a	DET
dti-3495	186	9	molecular	molecular	ADJ
dti-3495	186	10	weight	weight	NOUN
dti-3495	186	11	of	of	ADP
dti-3495	186	12	154.12	154.12	NUM
dti-3495	186	13	g/	g/	NOUN
dti-3495	186	14	mol	mol	NOUN
dti-3495	186	15	,	,	PUNCT
dti-3495	186	16	displayed	display	VERB
dti-3495	186	17	a	a	DET
dti-3495	186	18	lower	low	ADJ
dti-3495	186	19	drug	drug	NOUN
dti-3495	186	20	likeness	likeness	NOUN
dti-3495	186	21	score	score	NOUN
dti-3495	186	22	of	of	ADP
dti-3495	186	23	0.23	0.23	NUM
dti-3495	186	24	but	but	CCONJ
dti-3495	186	25	a	a	DET
dti-3495	186	26	slightly	slightly	ADV
dti-3495	186	27	higher	high	ADJ
dti-3495	186	28	oral	oral	ADJ
dti-3495	186	29	bioavailability	bioavailability	NOUN
dti-3495	186	30	of	of	ADP
dti-3495	186	31	0.56	0.56	NUM
dti-3495	186	32	,	,	PUNCT
dti-3495	186	33	suggesting	suggest	VERB
dti-3495	186	34	that	that	SCONJ
dti-3495	186	35	while	while	SCONJ
dti-3495	186	36	its	its	PRON
dti-3495	186	37	drug	drug	NOUN
dti-3495	186	38	-	-	PUNCT
dti-3495	186	39	like	like	ADJ
dti-3495	186	40	properties	property	NOUN
dti-3495	186	41	may	may	AUX
dti-3495	186	42	be	be	AUX
dti-3495	186	43	limited	limit	VERB
dti-3495	186	44	,	,	PUNCT
dti-3495	186	45	it	it	PRON
dti-3495	186	46	could	could	AUX
dti-3495	186	47	still	still	ADV
dti-3495	186	48	be	be	AUX
dti-3495	186	49	bioavailable	bioavailable	ADJ
dti-3495	186	50	if	if	SCONJ
dti-3495	186	51	administered	administer	VERB
dti-3495	186	52	orally	orally	ADV
dti-3495	186	53	.	.	PUNCT
dti-3495	187	1	isoflavones	isoflavone	NOUN
dti-3495	187	2	such	such	ADJ
dti-3495	187	3	as	as	ADP
dti-3495	187	4	genistein	genistein	NOUN
dti-3495	187	5	,	,	PUNCT
dti-3495	187	6	daidzein	daidzein	ADJ
dti-3495	187	7	,	,	PUNCT
dti-3495	187	8	and	and	CCONJ
dti-3495	187	9	glycitein	glycitein	ADJ
dti-3495	187	10	were	be	AUX
dti-3495	187	11	also	also	ADV
dti-3495	187	12	included	include	VERB
dti-3495	187	13	in	in	ADP
dti-3495	187	14	the	the	DET
dti-3495	187	15	screening	screening	NOUN
dti-3495	187	16	.	.	PUNCT
dti-3495	188	1	these	these	DET
dti-3495	188	2	compounds	compound	NOUN
dti-3495	188	3	have	have	VERB
dti-3495	188	4	molecular	molecular	ADJ
dti-3495	188	5	weights	weight	NOUN
dti-3495	188	6	between	between	ADP
dti-3495	188	7	254.24	254.24	NUM
dti-3495	188	8	and	and	CCONJ
dti-3495	188	9	284.26	284.26	NUM
dti-3495	188	10	g	g	NOUN
dti-3495	188	11	/	/	SYM
dti-3495	188	12	mol	mol	NOUN
dti-3495	188	13	and	and	CCONJ
dti-3495	188	14	exhibit	exhibit	VERB
dti-3495	188	15	moderate	moderate	ADJ
dti-3495	188	16	drug	drug	NOUN
dti-3495	188	17	likeness	likeness	NOUN
dti-3495	188	18	,	,	PUNCT
dti-3495	188	19	with	with	ADP
dti-3495	188	20	genistein	genistein	NOUN
dti-3495	188	21	having	have	VERB
dti-3495	188	22	a	a	DET
dti-3495	188	23	dl	dl	NOUN
dti-3495	188	24	of	of	ADP
dti-3495	188	25	0.44	0.44	NUM
dti-3495	188	26	.	.	PUNCT
dti-3495	189	1	like	like	ADP
dti-3495	189	2	the	the	DET
dti-3495	189	3	flavonoids	flavonoid	NOUN
dti-3495	189	4	,	,	PUNCT
dti-3495	189	5	they	they	PRON
dti-3495	189	6	all	all	PRON
dti-3495	189	7	have	have	VERB
dti-3495	189	8	an	an	DET
dti-3495	189	9	oral	oral	ADJ
dti-3495	189	10	bioavailability	bioavailability	NOUN
dti-3495	189	11	of	of	ADP
dti-3495	189	12	0.55	0.55	NUM
dti-3495	189	13	.	.	PUNCT
dti-3495	190	1	in	in	ADP
dti-3495	190	2	the	the	DET
dti-3495	190	3	category	category	NOUN
dti-3495	190	4	of	of	ADP
dti-3495	190	5	triterpenoids	triterpenoids	PROPN
dti-3495	190	6	,	,	PUNCT
dti-3495	190	7	betulinic	betulinic	PROPN
dti-3495	190	8	acid	acid	PROPN
dti-3495	190	9	stands	stand	VERB
dti-3495	190	10	out	out	ADP
dti-3495	190	11	with	with	ADP
dti-3495	190	12	a	a	DET
dti-3495	190	13	significantly	significantly	ADV
dti-3495	190	14	higher	high	ADJ
dti-3495	190	15	molecular	molecular	ADJ
dti-3495	190	16	weight	weight	NOUN
dti-3495	190	17	of	of	ADP
dti-3495	190	18	456.7	456.7	NUM
dti-3495	190	19	g	g	NOUN
dti-3495	190	20	/	/	SYM
dti-3495	190	21	mol	mol	PROPN
dti-3495	190	22	,	,	PUNCT
dti-3495	190	23	a	a	DET
dti-3495	190	24	drug	drug	NOUN
dti-3495	190	25	likeness	likeness	NOUN
dti-3495	190	26	score	score	NOUN
dti-3495	190	27	of	of	ADP
dti-3495	190	28	0.25	0.25	NUM
dti-3495	190	29	,	,	PUNCT
dti-3495	190	30	and	and	CCONJ
dti-3495	190	31	a	a	DET
dti-3495	190	32	notably	notably	ADV
dti-3495	190	33	higher	high	ADJ
dti-3495	190	34	oral	oral	ADJ
dti-3495	190	35	bioavailability	bioavailability	NOUN
dti-3495	190	36	of	of	ADP
dti-3495	190	37	0.85	0.85	NUM
dti-3495	190	38	,	,	PUNCT
dti-3495	190	39	suggesting	suggest	VERB
dti-3495	190	40	its	its	PRON
dti-3495	190	41	strong	strong	ADJ
dti-3495	190	42	potential	potential	NOUN
dti-3495	190	43	as	as	ADP
dti-3495	190	44	an	an	DET
dti-3495	190	45	orally	orally	ADV
dti-3495	190	46	administered	administer	VERB
dti-3495	190	47	drug	drug	NOUN
dti-3495	190	48	candidate	candidate	NOUN
dti-3495	190	49	.	.	PUNCT
dti-3495	191	1	the	the	DET
dti-3495	191	2	phytosterols	phytosterol	NOUN
dti-3495	191	3	identified	identify	VERB
dti-3495	191	4	include	include	VERB
dti-3495	191	5	beta	beta	NOUN
dti-3495	191	6	-	-	PUNCT
dti-3495	191	7	sitosterol	sitosterol	NOUN
dti-3495	191	8	,	,	PUNCT
dti-3495	191	9	campesterol	campesterol	NOUN
dti-3495	191	10	,	,	PUNCT
dti-3495	191	11	and	and	CCONJ
dti-3495	191	12	stigmasterol	stigmasterol	NOUN
dti-3495	191	13	,	,	PUNCT
dti-3495	191	14	with	with	ADP
dti-3495	191	15	molecular	molecular	ADJ
dti-3495	191	16	weights	weight	NOUN
dti-3495	191	17	around	around	ADP
dti-3495	191	18	400	400	NUM
dti-3495	191	19	to	to	PART
dti-3495	191	20	414	414	NUM
dti-3495	191	21	g	g	NOUN
dti-3495	191	22	/	/	SYM
dti-3495	191	23	mol	mol	NOUN
dti-3495	191	24	.	.	PUNCT
dti-3495	192	1	these	these	DET
dti-3495	192	2	compounds	compound	NOUN
dti-3495	192	3	showed	show	VERB
dti-3495	192	4	varying	vary	VERB
dti-3495	192	5	drug	drug	NOUN
dti-3495	192	6	likeness	likeness	NOUN
dti-3495	192	7	scores	score	NOUN
dti-3495	192	8	,	,	PUNCT
dti-3495	192	9	with	with	ADP
dti-3495	192	10	betasitosterol	betasitosterol	NOUN
dti-3495	192	11	achieving	achieve	VERB
dti-3495	192	12	the	the	DET
dti-3495	192	13	highest	high	ADJ
dti-3495	192	14	dl	dl	NOUN
dti-3495	192	15	of	of	ADP
dti-3495	192	16	0.78	0.78	NUM
dti-3495	192	17	,	,	PUNCT
dti-3495	192	18	and	and	CCONJ
dti-3495	192	19	all	all	DET
dti-3495	192	20	three	three	NUM
dti-3495	192	21	exhibiting	exhibit	VERB
dti-3495	192	22	an	an	DET
dti-3495	192	23	oral	oral	ADJ
dti-3495	192	24	bioavailability	bioavailability	NOUN
dti-3495	192	25	of	of	ADP
dti-3495	192	26	0.55	0.55	NUM
dti-3495	192	27	.	.	PUNCT
dti-3495	193	1	finally	finally	ADV
dti-3495	193	2	,	,	PUNCT
dti-3495	193	3	vicine	vicine	PROPN
dti-3495	193	4	,	,	PUNCT
dti-3495	193	5	an	an	DET
dti-3495	193	6	alkaloid	alkaloid	NOUN
dti-3495	193	7	with	with	ADP
dti-3495	193	8	a	a	DET
dti-3495	193	9	molecular	molecular	ADJ
dti-3495	193	10	weight	weight	NOUN
dti-3495	193	11	of	of	ADP
dti-3495	193	12	304.26	304.26	NUM
dti-3495	193	13	g	g	NOUN
dti-3495	193	14	/	/	SYM
dti-3495	193	15	mol	mol	NOUN
dti-3495	193	16	,	,	PUNCT
dti-3495	193	17	demonstrated	demonstrate	VERB
dti-3495	193	18	the	the	DET
dti-3495	193	19	highest	high	ADJ
dti-3495	193	20	drug	drug	NOUN
dti-3495	193	21	likeness	likeness	NOUN
dti-3495	193	22	score	score	NOUN
dti-3495	193	23	of	of	ADP
dti-3495	193	24	0.84	0.84	NUM
dti-3495	193	25	among	among	ADP
dti-3495	193	26	the	the	DET
dti-3495	193	27	compounds	compound	NOUN
dti-3495	193	28	screened	screen	VERB
dti-3495	193	29	,	,	PUNCT
dti-3495	193	30	coupled	couple	VERB
dti-3495	193	31	with	with	ADP
dti-3495	193	32	an	an	DET
dti-3495	193	33	oral	oral	ADJ
dti-3495	193	34	bioavailability	bioavailability	NOUN
dti-3495	193	35	of	of	ADP
dti-3495	193	36	0.55	0.55	NUM
dti-3495	193	37	,	,	PUNCT
dti-3495	193	38	highlighting	highlight	VERB
dti-3495	193	39	it	it	PRON
dti-3495	193	40	as	as	ADP
dti-3495	193	41	a	a	DET
dti-3495	193	42	particularly	particularly	ADV
dti-3495	193	43	promising	promising	ADJ
dti-3495	193	44	candidate	candidate	NOUN
dti-3495	193	45	for	for	ADP
dti-3495	193	46	further	further	ADJ
dti-3495	193	47	drug	drug	NOUN
dti-3495	193	48	development	development	NOUN
dti-3495	193	49	.	.	PUNCT
dti-3495	194	1	overall	overall	ADV
dti-3495	194	2	,	,	PUNCT
dti-3495	194	3	the	the	DET
dti-3495	194	4	screening	screening	NOUN
dti-3495	194	5	results	result	NOUN
dti-3495	194	6	indicate	indicate	VERB
dti-3495	194	7	that	that	SCONJ
dti-3495	194	8	several	several	ADJ
dti-3495	194	9	compounds	compound	NOUN
dti-3495	194	10	from	from	ADP
dti-3495	194	11	v.	v.	ADP
dti-3495	194	12	unguiculata	unguiculata	ADJ
dti-3495	194	13	possess	possess	NOUN
dti-3495	194	14	favorable	favorable	ADJ
dti-3495	194	15	drug	drug	NOUN
dti-3495	194	16	-	-	PUNCT
dti-3495	194	17	like	like	ADJ
dti-3495	194	18	properties	property	NOUN
dti-3495	194	19	and	and	CCONJ
dti-3495	194	20	oral	oral	ADJ
dti-3495	194	21	bioavailability	bioavailability	NOUN
dti-3495	194	22	,	,	PUNCT
dti-3495	194	23	making	make	VERB
dti-3495	194	24	them	they	PRON
dti-3495	194	25	viable	viable	ADJ
dti-3495	194	26	candidates	candidate	NOUN
dti-3495	194	27	for	for	ADP
dti-3495	194	28	further	further	ADJ
dti-3495	194	29	investigation	investigation	NOUN
dti-3495	194	30	in	in	ADP
dti-3495	194	31	drug	drug	NOUN
dti-3495	194	32	development	development	NOUN
dti-3495	194	33	efforts	effort	NOUN
dti-3495	194	34	.	.	PUNCT
dti-3495	195	1	similarly	similarly	ADV
dti-3495	195	2	,	,	PUNCT
dti-3495	195	3	the	the	DET
dti-3495	195	4	comprehensive	comprehensive	ADJ
dti-3495	195	5	pharmacokinetic	pharmacokinetic	ADJ
dti-3495	195	6	studies	study	NOUN
dti-3495	195	7	of	of	ADP
dti-3495	195	8	the	the	DET
dti-3495	195	9	selected	select	VERB
dti-3495	195	10	compounds	compound	NOUN
dti-3495	195	11	,	,	PUNCT
dti-3495	195	12	including	include	VERB
dti-3495	195	13	stigmasterol	stigmasterol	NOUN
dti-3495	195	14	,	,	PUNCT
dti-3495	195	15	quercetin	quercetin	NOUN
dti-3495	195	16	,	,	PUNCT
dti-3495	195	17	luteoline	luteoline	NOUN
dti-3495	195	18	,	,	PUNCT
dti-3495	195	19	and	and	CCONJ
dti-3495	195	20	acarbose	acarbose	NOUN
dti-3495	195	21	,	,	PUNCT
dti-3495	195	22	are	be	AUX
dti-3495	195	23	shown	show	VERB
dti-3495	195	24	in	in	ADP
dti-3495	195	25	the	the	DET
dti-3495	195	26	supplementary	supplementary	ADJ
dti-3495	195	27	table	table	NOUN
dti-3495	195	28	1	1	NUM
dti-3495	195	29	.	.	PUNCT
dti-3495	195	30	table	table	NOUN
dti-3495	195	31	1	1	NUM
dti-3495	195	32	summarizes	summarize	NOUN
dti-3495	195	33	the	the	DET
dti-3495	195	34	list	list	NOUN
dti-3495	195	35	of	of	ADP
dti-3495	195	36	compounds	compound	NOUN
dti-3495	195	37	obtained	obtain	VERB
dti-3495	195	38	from	from	ADP
dti-3495	195	39	v.	v.	ADP
dti-3495	195	40	unguiculata	unguiculata	PROPN
dti-3495	195	41	with	with	ADP
dti-3495	195	42	drug	drug	NOUN
dti-3495	195	43	-	-	PUNCT
dti-3495	195	44	like	like	ADJ
dti-3495	195	45	potential	potential	ADJ
dti-3495	195	46	compound	compound	NOUN
dti-3495	195	47	compound	compound	NOUN
dti-3495	195	48	class	class	NOUN
dti-3495	195	49	molecular	molecular	ADJ
dti-3495	195	50	weight	weight	NOUN
dti-3495	195	51	(	(	PUNCT
dti-3495	195	52	mw	mw	NOUN
dti-3495	195	53	)	)	PUNCT
dti-3495	195	54	drug	drug	NOUN
dti-3495	195	55	likeness	likeness	NOUN
dti-3495	195	56	(	(	PUNCT
dti-3495	195	57	dl	dl	NOUN
dti-3495	195	58	)	)	PUNCT
dti-3495	195	59	oral	oral	ADJ
dti-3495	195	60	bioavailability	bioavailability	NOUN
dti-3495	195	61	(	(	PUNCT
dti-3495	195	62	ob	ob	NOUN
dti-3495	195	63	)	)	PUNCT
dti-3495	195	64	quercetin	quercetin	NOUN
dti-3495	195	65	flavonoid	flavonoid	NOUN
dti-3495	195	66	302.23	302.23	NUM
dti-3495	195	67	0.52	0.52	NUM
dti-3495	195	68	0.55	0.55	NUM
dti-3495	195	69	kaempferol	kaempferol	NOUN
dti-3495	195	70	flavonoid	flavonoid	NOUN
dti-3495	195	71	286.24	286.24	NUM
dti-3495	195	72	0.5	0.5	NUM
dti-3495	195	73	0.55	0.55	NUM
dti-3495	195	74	catechin	catechin	NOUN
dti-3495	195	75	flavonoid	flavonoid	NOUN
dti-3495	195	76	290.27	290.27	NUM
dti-3495	195	77	0.64	0.64	NUM
dti-3495	195	78	0.55	0.55	NUM
dti-3495	195	79	luteolin	luteolin	PROPN
dti-3495	195	80	flavonoid	flavonoid	NOUN
dti-3495	195	81	286.24	286.24	NUM
dti-3495	195	82	0.38	0.38	NUM
dti-3495	195	83	0.55	0.55	NUM
dti-3495	195	84	apigenin	apigenin	ADJ
dti-3495	195	85	flavonoid	flavonoid	NOUN
dti-3495	195	86	270.24	270.24	NUM
dti-3495	195	87	0.39	0.39	NUM
dti-3495	195	88	0.55	0.55	NUM
dti-3495	195	89	protocatechuic	protocatechuic	PROPN
dti-3495	195	90	acid	acid	PROPN
dti-3495	195	91	phenolic	phenolic	NOUN
dti-3495	195	92	acid	acid	NOUN
dti-3495	195	93	154.12	154.12	NUM
dti-3495	195	94	0.23	0.23	NUM
dti-3495	195	95	0.56	0.56	NUM
dti-3495	195	96	genistein	genistein	NOUN
dti-3495	195	97	isoflavone	isoflavone	VERB
dti-3495	195	98	270.24	270.24	NUM
dti-3495	195	99	0.44	0.44	NUM
dti-3495	195	100	0.55	0.55	NUM
dti-3495	195	101	daidzein	daidzein	ADJ
dti-3495	195	102	isoflavone	isoflavone	NOUN
dti-3495	195	103	254.24	254.24	NUM
dti-3495	195	104	0.29	0.29	NUM
dti-3495	195	105	0.55	0.55	NUM
dti-3495	195	106	glycitein	glycitein	ADJ
dti-3495	195	107	isoflavone	isoflavone	NOUN
dti-3495	195	108	284.26	284.26	NUM
dti-3495	195	109	0.37	0.37	NUM
dti-3495	195	110	0.55	0.55	NUM
dti-3495	195	111	betulinic	betulinic	ADJ
dti-3495	195	112	acid	acid	NOUN
dti-3495	195	113	triterpenoid	triterpenoid	VERB
dti-3495	195	114	456.7	456.7	NUM
dti-3495	195	115	0.25	0.25	NUM
dti-3495	195	116	0.85	0.85	NUM
dti-3495	195	117	beta	beta	NOUN
dti-3495	195	118	-	-	PUNCT
dti-3495	195	119	sitosterol	sitosterol	NOUN
dti-3495	195	120	phytosterol	phytosterol	NOUN
dti-3495	195	121	414.7	414.7	NUM
dti-3495	195	122	0.78	0.78	NUM
dti-3495	195	123	0.55	0.55	NUM
dti-3495	195	124	campesterol	campesterol	NOUN
dti-3495	195	125	phytosterol	phytosterol	NOUN
dti-3495	195	126	400.7	400.7	NUM
dti-3495	195	127	0.59	0.59	NUM
dti-3495	195	128	0.55	0.55	NUM
dti-3495	195	129	stigmasterol	stigmasterol	NOUN
dti-3495	195	130	phytosterol	phytosterol	NOUN
dti-3495	195	131	412.7	412.7	NUM
dti-3495	195	132	0.62	0.62	NUM
dti-3495	195	133	0.55	0.55	NUM
dti-3495	195	134	vicine	vicine	ADJ
dti-3495	195	135	alkaloid	alkaloid	PROPN
dti-3495	195	136	304.26	304.26	NUM
dti-3495	195	137	0.84	0.84	NUM
dti-3495	195	138	0.55	0.55	NUM
dti-3495	195	139	acarbose	acarbose	NOUN
dti-3495	195	140	oligosaccharide	oligosaccharide	NOUN
dti-3495	195	141	645.608	645.608	NUM
dti-3495	195	142	0.17	0.17	NUM
dti-3495	195	143	3.4.2	3.4.2	NUM
dti-3495	195	144	.	.	PUNCT
dti-3495	196	1	microarray	microarray	PROPN
dti-3495	196	2	data	data	PROPN
dti-3495	196	3	analysis	analysis	NOUN
dti-3495	196	4	microarray	microarray	NOUN
dti-3495	196	5	gene	gene	NOUN
dti-3495	196	6	expression	expression	NOUN
dti-3495	196	7	data	datum	NOUN
dti-3495	196	8	were	be	AUX
dti-3495	196	9	analyzed	analyze	VERB
dti-3495	196	10	using	use	VERB
dti-3495	196	11	datasets	dataset	NOUN
dti-3495	196	12	obtained	obtain	VERB
dti-3495	196	13	from	from	ADP
dti-3495	196	14	the	the	DET
dti-3495	196	15	geo	geo	PROPN
dti-3495	196	16	database	database	NOUN
dti-3495	196	17	.	.	PUNCT
dti-3495	197	1	additionally	additionally	ADV
dti-3495	197	2	,	,	PUNCT
dti-3495	197	3	the	the	DET
dti-3495	197	4	gse22435	gse22435	NOUN
dti-3495	197	5	dataset	dataset	NOUN
dti-3495	197	6	contained	contain	VERB
dti-3495	197	7	data	datum	NOUN
dti-3495	197	8	from	from	ADP
dti-3495	197	9	7	7	NUM
dti-3495	197	10	affected	affect	VERB
dti-3495	197	11	individuals	individual	NOUN
dti-3495	197	12	and	and	CCONJ
dti-3495	197	13	10	10	NUM
dti-3495	197	14	healthy	healthy	ADJ
dti-3495	197	15	controls	control	NOUN
dti-3495	197	16	(	(	PUNCT
dti-3495	197	17	fig	fig	NOUN
dti-3495	197	18	.	.	PUNCT
dti-3495	197	19	4a	4a	NOUN
dti-3495	197	20	and	and	CCONJ
dti-3495	197	21	4d	4d	NUM
dti-3495	197	22	)	)	PUNCT
dti-3495	197	23	.	.	PUNCT
dti-3495	198	1	differential	differential	ADJ
dti-3495	198	2	expression	expression	NOUN
dti-3495	198	3	analysis	analysis	NOUN
dti-3495	198	4	was	be	AUX
dti-3495	198	5	conducted	conduct	VERB
dti-3495	198	6	using	use	VERB
dti-3495	198	7	the	the	DET
dti-3495	198	8	limma	limma	NOUN
dti-3495	198	9	package	package	NOUN
dti-3495	198	10	,	,	PUNCT
dti-3495	198	11	resulting	result	VERB
dti-3495	198	12	in	in	ADP
dti-3495	198	13	the	the	DET
dti-3495	198	14	identification	identification	NOUN
dti-3495	198	15	of	of	ADP
dti-3495	198	16	a	a	DET
dti-3495	198	17	significant	significant	ADJ
dti-3495	198	18	number	number	NOUN
dti-3495	198	19	of	of	ADP
dti-3495	198	20	differentially	differentially	ADV
dti-3495	198	21	expressed	express	VERB
dti-3495	198	22	genes	gene	NOUN
dti-3495	198	23	(	(	PUNCT
dti-3495	198	24	degs	deg	NOUN
dti-3495	198	25	)	)	PUNCT
dti-3495	198	26	across	across	ADP
dti-3495	198	27	these	these	DET
dti-3495	198	28	datasets	dataset	NOUN
dti-3495	198	29	.	.	PUNCT
dti-3495	199	1	specifically	specifically	ADV
dti-3495	199	2	,	,	PUNCT
dti-3495	199	3	the	the	DET
dti-3495	199	4	analysis	analysis	NOUN
dti-3495	199	5	of	of	ADP
dti-3495	199	6	gse22435	gse22435	NOUN
dti-3495	199	7	revealed	reveal	VERB
dti-3495	199	8	671	671	NUM
dti-3495	199	9	upregulated	upregulate	VERB
dti-3495	199	10	and	and	CCONJ
dti-3495	199	11	198	198	NUM
dti-3495	199	12	downregulated	downregulate	VERB
dti-3495	199	13	genes	gene	NOUN
dti-3495	199	14	,	,	PUNCT
dti-3495	199	15	leading	lead	VERB
dti-3495	199	16	to	to	ADP
dti-3495	199	17	a	a	DET
dti-3495	199	18	total	total	NOUN
dti-3495	199	19	of	of	ADP
dti-3495	199	20	870	870	NUM
dti-3495	199	21	degs	deg	NOUN
dti-3495	199	22	.	.	PUNCT
dti-3495	200	1	in	in	ADP
dti-3495	200	2	the	the	DET
dti-3495	200	3	gse43950	gse43950	NOUN
dti-3495	200	4	dataset	dataset	NOUN
dti-3495	200	5	,	,	PUNCT
dti-3495	200	6	2,133	2,133	NUM
dti-3495	200	7	degs	deg	NOUN
dti-3495	200	8	were	be	AUX
dti-3495	200	9	identified	identify	VERB
dti-3495	200	10	(	(	PUNCT
dti-3495	200	11	fig	fig	NOUN
dti-3495	200	12	.	.	PUNCT
dti-3495	201	1	4b	4b	PROPN
dti-3495	201	2	and	and	CCONJ
dti-3495	201	3	4e	4e	PROPN
dti-3495	201	4	)	)	PUNCT
dti-3495	201	5	,	,	PUNCT
dti-3495	201	6	and	and	CCONJ
dti-3495	201	7	the	the	DET
dti-3495	201	8	gse92724	gse92724	PROPN
dti-3495	201	9	dataset	dataset	PROPN
dti-3495	201	10	yielded	yield	VERB
dti-3495	201	11	1,160	1,160	NUM
dti-3495	201	12	degs	deg	NOUN
dti-3495	201	13	(	(	PUNCT
dti-3495	201	14	fig	fig	NOUN
dti-3495	201	15	.	.	PUNCT
dti-3495	202	1	4c	4c	NOUN
dti-3495	202	2	and	and	CCONJ
dti-3495	202	3	4f	4f	NUM
dti-3495	202	4	)	)	PUNCT
dti-3495	202	5	.	.	PUNCT
dti-3495	203	1	all	all	DET
dti-3495	203	2	identified	identify	VERB
dti-3495	203	3	degs	deg	NOUN
dti-3495	203	4	met	meet	VERB
dti-3495	203	5	the	the	DET
dti-3495	203	6	stringent	stringent	ADJ
dti-3495	203	7	criteria	criterion	NOUN
dti-3495	203	8	of	of	ADP
dti-3495	203	9	an	an	DET
dti-3495	203	10	adjusted	adjust	VERB
dti-3495	203	11	p	p	NOUN
dti-3495	203	12	-	-	PUNCT
dti-3495	203	13	value	value	NOUN
dti-3495	203	14	less	less	ADJ
dti-3495	203	15	than	than	ADP
dti-3495	203	16	0.05	0.05	NUM
dti-3495	203	17	and	and	CCONJ
dti-3495	203	18	an	an	DET
dti-3495	203	19	absolute	absolute	ADJ
dti-3495	203	20	log	log	NOUN
dti-3495	203	21	fold	fold	NOUN
dti-3495	203	22	change	change	NOUN
dti-3495	203	23	(	(	PUNCT
dti-3495	203	24	|log(fc)|	|log(fc)|	NOUN
dti-3495	203	25	)	)	PUNCT
dti-3495	203	26	of	of	ADP
dti-3495	203	27	greater	great	ADJ
dti-3495	203	28	than	than	ADP
dti-3495	203	29	or	or	CCONJ
dti-3495	203	30	equal	equal	ADJ
dti-3495	203	31	to	to	ADP
dti-3495	203	32	1	1	NUM
dti-3495	203	33	.	.	PUNCT
dti-3495	204	1	these	these	DET
dti-3495	204	2	findings	finding	NOUN
dti-3495	204	3	underscore	underscore	VERB
dti-3495	204	4	the	the	DET
dti-3495	204	5	substantial	substantial	ADJ
dti-3495	204	6	alterations	alteration	NOUN
dti-3495	204	7	in	in	ADP
dti-3495	204	8	gene	gene	NOUN
dti-3495	204	9	expression	expression	NOUN
dti-3495	204	10	in	in	ADP
dti-3495	204	11	silico	silico	NOUN
dti-3495	204	12	anti	anti	ADJ
dti-3495	204	13	-	-	ADJ
dti-3495	204	14	diabetic	diabetic	ADJ
dti-3495	204	15	potential	potential	NOUN
dti-3495	204	16	of	of	ADP
dti-3495	204	17	vigna	vigna	PROPN
dti-3495	204	18	unguiculata78	unguiculata78	PROPN
dti-3495	205	1	©	©	ADP
dti-3495	205	2	2025	2025	NUM
dti-3495	205	3	the	the	DET
dti-3495	205	4	authors	author	NOUN
dti-3495	205	5	.	.	PUNCT
dti-3495	206	1	drug	drug	NOUN
dti-3495	206	2	target	target	NOUN
dti-3495	206	3	insights	insight	NOUN
dti-3495	206	4	issn	issn	VERB
dti-3495	206	5	1177	1177	NUM
dti-3495	206	6	-	-	SYM
dti-3495	206	7	3928	3928	NUM
dti-3495	206	8	www.aboutscience.eu/dti	www.aboutscience.eu/dti	NOUN
dti-3495	206	9	between	between	ADP
dti-3495	206	10	affected	affect	VERB
dti-3495	206	11	individuals	individual	NOUN
dti-3495	206	12	and	and	CCONJ
dti-3495	206	13	controls	control	NOUN
dti-3495	206	14	,	,	PUNCT
dti-3495	206	15	providing	provide	VERB
dti-3495	206	16	a	a	DET
dti-3495	206	17	robust	robust	ADJ
dti-3495	206	18	basis	basis	NOUN
dti-3495	206	19	for	for	ADP
dti-3495	206	20	further	further	ADJ
dti-3495	206	21	biological	biological	ADJ
dti-3495	206	22	interpretation	interpretation	NOUN
dti-3495	206	23	and	and	CCONJ
dti-3495	206	24	validation	validation	NOUN
dti-3495	206	25	.	.	PUNCT
dti-3495	207	1	target	target	NOUN
dti-3495	207	2	identification	identification	NOUN
dti-3495	207	3	a	a	DET
dti-3495	207	4	comprehensive	comprehensive	ADJ
dti-3495	207	5	target	target	NOUN
dti-3495	207	6	identification	identification	NOUN
dti-3495	207	7	process	process	NOUN
dti-3495	207	8	was	be	AUX
dti-3495	207	9	carried	carry	VERB
dti-3495	207	10	out	out	ADP
dti-3495	207	11	,	,	PUNCT
dti-3495	207	12	resulting	result	VERB
dti-3495	207	13	in	in	ADP
dti-3495	207	14	the	the	DET
dti-3495	207	15	identification	identification	NOUN
dti-3495	207	16	of	of	ADP
dti-3495	207	17	1,310	1,310	NUM
dti-3495	207	18	targets	target	NOUN
dti-3495	207	19	for	for	ADP
dti-3495	207	20	14	14	NUM
dti-3495	207	21	active	active	ADJ
dti-3495	207	22	compounds	compound	NOUN
dti-3495	207	23	using	use	VERB
dti-3495	207	24	the	the	DET
dti-3495	207	25	stitch	stitch	NOUN
dti-3495	207	26	and	and	CCONJ
dti-3495	207	27	swisstarget	swisstarget	NOUN
dti-3495	207	28	prediction	prediction	NOUN
dti-3495	207	29	databases	database	NOUN
dti-3495	207	30	.	.	PUNCT
dti-3495	208	1	these	these	DET
dti-3495	208	2	targets	target	NOUN
dti-3495	208	3	were	be	AUX
dti-3495	208	4	then	then	ADV
dti-3495	208	5	cross	cross	ADJ
dti-3495	208	6	-	-	ADJ
dti-3495	208	7	referenced	referenced	ADJ
dti-3495	208	8	with	with	ADP
dti-3495	208	9	the	the	DET
dti-3495	208	10	degs	deg	NOUN
dti-3495	208	11	identified	identify	VERB
dti-3495	208	12	through	through	ADP
dti-3495	208	13	the	the	DET
dti-3495	208	14	microarray	microarray	NOUN
dti-3495	208	15	data	datum	NOUN
dti-3495	208	16	analysis	analysis	NOUN
dti-3495	208	17	.	.	PUNCT
dti-3495	209	1	this	this	DET
dti-3495	209	2	comparison	comparison	NOUN
dti-3495	209	3	revealed	reveal	VERB
dti-3495	209	4	88	88	NUM
dti-3495	209	5	common	common	ADJ
dti-3495	209	6	genes	gene	NOUN
dti-3495	209	7	that	that	PRON
dti-3495	209	8	are	be	AUX
dti-3495	209	9	implicated	implicate	VERB
dti-3495	209	10	in	in	ADP
dti-3495	209	11	both	both	CCONJ
dti-3495	209	12	the	the	DET
dti-3495	209	13	disease	disease	NOUN
dti-3495	209	14	context	context	NOUN
dti-3495	209	15	and	and	CCONJ
dti-3495	209	16	the	the	DET
dti-3495	209	17	plant	plant	NOUN
dti-3495	209	18	-	-	PUNCT
dti-3495	209	19	derived	derive	VERB
dti-3495	209	20	compounds	compound	NOUN
dti-3495	209	21	(	(	PUNCT
dti-3495	209	22	fig	fig	NOUN
dti-3495	209	23	.	.	PUNCT
dti-3495	210	1	5a	5a	NUM
dti-3495	210	2	)	)	PUNCT
dti-3495	210	3	.	.	PUNCT
dti-3495	211	1	the	the	DET
dti-3495	211	2	compound	compound	NOUN
dti-3495	211	3	-	-	PUNCT
dti-3495	211	4	target	target	NOUN
dti-3495	211	5	network	network	NOUN
dti-3495	211	6	analysis	analysis	NOUN
dti-3495	211	7	demonstrated	demonstrate	VERB
dti-3495	211	8	that	that	SCONJ
dti-3495	211	9	these	these	DET
dti-3495	211	10	88	88	NUM
dti-3495	211	11	genes	gene	NOUN
dti-3495	211	12	were	be	AUX
dti-3495	211	13	targeted	target	VERB
dti-3495	211	14	by	by	ADP
dti-3495	211	15	multiple	multiple	ADJ
dti-3495	211	16	compounds	compound	NOUN
dti-3495	211	17	,	,	PUNCT
dti-3495	211	18	indicating	indicate	VERB
dti-3495	211	19	their	their	PRON
dti-3495	211	20	potential	potential	NOUN
dti-3495	211	21	as	as	ADP
dti-3495	211	22	druggable	druggable	ADJ
dti-3495	211	23	targets	target	NOUN
dti-3495	211	24	.	.	PUNCT
dti-3495	212	1	network	network	NOUN
dti-3495	212	2	analysis	analysis	NOUN
dti-3495	212	3	following	follow	VERB
dti-3495	212	4	the	the	DET
dti-3495	212	5	identification	identification	NOUN
dti-3495	212	6	of	of	ADP
dti-3495	212	7	the	the	DET
dti-3495	212	8	88	88	NUM
dti-3495	212	9	common	common	ADJ
dti-3495	212	10	genes	gene	NOUN
dti-3495	212	11	,	,	PUNCT
dti-3495	212	12	a	a	DET
dti-3495	212	13	protein	protein	NOUN
dti-3495	212	14	-	-	PUNCT
dti-3495	212	15	protein	protein	NOUN
dti-3495	212	16	interaction	interaction	NOUN
dti-3495	212	17	(	(	PUNCT
dti-3495	212	18	ppi	ppi	NOUN
dti-3495	212	19	)	)	PUNCT
dti-3495	212	20	network	network	NOUN
dti-3495	212	21	was	be	AUX
dti-3495	212	22	constructed	construct	VERB
dti-3495	212	23	(	(	PUNCT
dti-3495	212	24	fig	fig	NOUN
dti-3495	212	25	.	.	PUNCT
dti-3495	213	1	5b	5b	NUM
dti-3495	213	2	)	)	PUNCT
dti-3495	213	3	.	.	PUNCT
dti-3495	214	1	the	the	DET
dti-3495	214	2	network	network	NOUN
dti-3495	214	3	consisted	consist	VERB
dti-3495	214	4	of	of	ADP
dti-3495	214	5	88	88	NUM
dti-3495	214	6	nodes	node	NOUN
dti-3495	214	7	and	and	CCONJ
dti-3495	214	8	144	144	NUM
dti-3495	214	9	edges	edge	NOUN
dti-3495	214	10	,	,	PUNCT
dti-3495	214	11	illustrating	illustrate	VERB
dti-3495	214	12	the	the	DET
dti-3495	214	13	complex	complex	ADJ
dti-3495	214	14	interactions	interaction	NOUN
dti-3495	214	15	among	among	ADP
dti-3495	214	16	these	these	DET
dti-3495	214	17	genes	gene	NOUN
dti-3495	214	18	.	.	PUNCT
dti-3495	215	1	further	further	ADJ
dti-3495	215	2	analysis	analysis	NOUN
dti-3495	215	3	identified	identify	VERB
dti-3495	215	4	the	the	DET
dti-3495	215	5	top	top	ADJ
dti-3495	215	6	10	10	NUM
dti-3495	215	7	genes	gene	NOUN
dti-3495	215	8	with	with	ADP
dti-3495	215	9	the	the	DET
dti-3495	215	10	highest	high	ADJ
dti-3495	215	11	degree	degree	NOUN
dti-3495	215	12	of	of	ADP
dti-3495	215	13	connectivity	connectivity	NOUN
dti-3495	215	14	within	within	ADP
dti-3495	215	15	the	the	DET
dti-3495	215	16	network	network	NOUN
dti-3495	215	17	(	(	PUNCT
dti-3495	215	18	fig	fig	NOUN
dti-3495	215	19	.	.	PUNCT
dti-3495	215	20	5c	5c	NUM
dti-3495	215	21	)	)	PUNCT
dti-3495	215	22	,	,	PUNCT
dti-3495	215	23	which	which	PRON
dti-3495	215	24	included	include	VERB
dti-3495	215	25	egfr	egfr	NOUN
dti-3495	215	26	(	(	PUNCT
dti-3495	215	27	degree	degree	NOUN
dti-3495	215	28	score	score	NOUN
dti-3495	215	29	of	of	ADP
dti-3495	215	30	43	43	NUM
dti-3495	215	31	)	)	PUNCT
dti-3495	215	32	,	,	PUNCT
dti-3495	215	33	src	src	NOUN
dti-3495	215	34	(	(	PUNCT
dti-3495	215	35	41	41	NUM
dti-3495	215	36	)	)	PUNCT
dti-3495	215	37	,	,	PUNCT
dti-3495	215	38	ptgs2	ptgs2	PROPN
dti-3495	215	39	(	(	PUNCT
dti-3495	215	40	39	39	NUM
dti-3495	215	41	)	)	PUNCT
dti-3495	215	42	,	,	PUNCT
dti-3495	215	43	mmp9	mmp9	PROPN
dti-3495	215	44	(	(	PUNCT
dti-3495	215	45	33	33	NUM
dti-3495	215	46	)	)	PUNCT
dti-3495	215	47	,	,	PUNCT
dti-3495	215	48	bcl2	bcl2	NOUN
dti-3495	215	49	(	(	PUNCT
dti-3495	215	50	33	33	NUM
dti-3495	215	51	)	)	PUNCT
dti-3495	215	52	,	,	PUNCT
dti-3495	215	53	tlr4	tlr4	NOUN
dti-3495	215	54	(	(	PUNCT
dti-3495	215	55	29	29	NUM
dti-3495	215	56	)	)	PUNCT
dti-3495	215	57	,	,	PUNCT
dti-3495	215	58	gsk3b	gsk3b	PROPN
dti-3495	215	59	(	(	PUNCT
dti-3495	215	60	26	26	NUM
dti-3495	215	61	)	)	PUNCT
dti-3495	215	62	,	,	PUNCT
dti-3495	215	63	ptprc	ptprc	NOUN
dti-3495	215	64	(	(	PUNCT
dti-3495	215	65	24	24	NUM
dti-3495	215	66	)	)	PUNCT
dti-3495	215	67	,	,	PUNCT
dti-3495	215	68	kit	kit	NOUN
dti-3495	215	69	(	(	PUNCT
dti-3495	215	70	22	22	NUM
dti-3495	215	71	)	)	PUNCT
dti-3495	215	72	,	,	PUNCT
dti-3495	215	73	and	and	CCONJ
dti-3495	215	74	bcl2l1	bcl2l1	NOUN
dti-3495	215	75	(	(	PUNCT
dti-3495	215	76	20	20	NUM
dti-3495	215	77	)	)	PUNCT
dti-3495	215	78	.	.	PUNCT
dti-3495	216	1	due	due	ADP
dti-3495	216	2	to	to	ADP
dti-3495	216	3	their	their	PRON
dti-3495	216	4	high	high	ADJ
dti-3495	216	5	connectivity	connectivity	NOUN
dti-3495	216	6	,	,	PUNCT
dti-3495	216	7	these	these	DET
dti-3495	216	8	genes	gene	NOUN
dti-3495	216	9	may	may	AUX
dti-3495	216	10	play	play	VERB
dti-3495	216	11	central	central	ADJ
dti-3495	216	12	roles	role	NOUN
dti-3495	216	13	in	in	ADP
dti-3495	216	14	the	the	DET
dti-3495	216	15	disease	disease	NOUN
dti-3495	216	16	mechanism	mechanism	NOUN
dti-3495	216	17	and	and	CCONJ
dti-3495	216	18	serve	serve	VERB
dti-3495	216	19	as	as	ADP
dti-3495	216	20	critical	critical	ADJ
dti-3495	216	21	targets	target	NOUN
dti-3495	216	22	for	for	ADP
dti-3495	216	23	therapeutic	therapeutic	ADJ
dti-3495	216	24	interventions	intervention	NOUN
dti-3495	216	25	.	.	PUNCT
dti-3495	217	1	figure	figure	VERB
dti-3495	217	2	4	4	NUM
dti-3495	217	3	differential	differential	ADJ
dti-3495	217	4	gene	gene	NOUN
dti-3495	217	5	expression	expression	NOUN
dti-3495	217	6	analysis	analysis	NOUN
dti-3495	217	7	for	for	ADP
dti-3495	217	8	geo	geo	PROPN
dti-3495	217	9	datasets	dataset	NOUN
dti-3495	217	10	gse22435	gse22435	NOUN
dti-3495	217	11	,	,	PUNCT
dti-3495	217	12	gse43950	gse43950	NOUN
dti-3495	217	13	,	,	PUNCT
dti-3495	217	14	and	and	CCONJ
dti-3495	217	15	gse92724	gse92724	X
dti-3495	217	16	.	.	PUNCT
dti-3495	218	1	(	(	PUNCT
dti-3495	218	2	a	a	X
dti-3495	218	3	)	)	PUNCT
dti-3495	218	4	,	,	PUNCT
dti-3495	218	5	(	(	PUNCT
dti-3495	218	6	b	b	NOUN
dti-3495	218	7	)	)	PUNCT
dti-3495	218	8	,	,	PUNCT
dti-3495	218	9	and	and	CCONJ
dti-3495	218	10	(	(	PUNCT
dti-3495	218	11	c	c	X
dti-3495	218	12	)	)	PUNCT
dti-3495	218	13	show	show	NOUN
dti-3495	218	14	umap	umap	ADJ
dti-3495	218	15	plots	plot	NOUN
dti-3495	218	16	,	,	PUNCT
dti-3495	218	17	boxplots	boxplot	NOUN
dti-3495	218	18	of	of	ADP
dti-3495	218	19	gene	gene	NOUN
dti-3495	218	20	expression	expression	NOUN
dti-3495	218	21	,	,	PUNCT
dti-3495	218	22	and	and	CCONJ
dti-3495	218	23	adjusted	adjust	VERB
dti-3495	218	24	p	p	ADJ
dti-3495	218	25	-	-	PUNCT
dti-3495	218	26	value	value	NOUN
dti-3495	218	27	distributions	distribution	NOUN
dti-3495	218	28	for	for	ADP
dti-3495	218	29	each	each	DET
dti-3495	218	30	dataset	dataset	NOUN
dti-3495	218	31	.	.	PUNCT
dti-3495	219	1	(	(	PUNCT
dti-3495	219	2	d	d	NOUN
dti-3495	219	3	)	)	PUNCT
dti-3495	219	4	,	,	PUNCT
dti-3495	219	5	(	(	PUNCT
dti-3495	219	6	e	e	NOUN
dti-3495	219	7	)	)	PUNCT
dti-3495	219	8	,	,	PUNCT
dti-3495	219	9	and	and	CCONJ
dti-3495	219	10	(	(	PUNCT
dti-3495	219	11	f	f	X
dti-3495	219	12	)	)	PUNCT
dti-3495	219	13	present	present	ADJ
dti-3495	219	14	volcano	volcano	NOUN
dti-3495	219	15	plots	plot	NOUN
dti-3495	219	16	highlighting	highlight	VERB
dti-3495	219	17	upregulated	upregulated	ADJ
dti-3495	219	18	(	(	PUNCT
dti-3495	219	19	red	red	ADJ
dti-3495	219	20	)	)	PUNCT
dti-3495	219	21	and	and	CCONJ
dti-3495	219	22	downregulated	downregulate	VERB
dti-3495	219	23	(	(	PUNCT
dti-3495	219	24	blue	blue	ADJ
dti-3495	219	25	)	)	PUNCT
dti-3495	219	26	genes	gene	NOUN
dti-3495	219	27	.	.	PUNCT
dti-3495	220	1	sardar	sardar	PROPN
dti-3495	220	2	et	et	PROPN
dti-3495	220	3	al	al	PROPN
dti-3495	220	4	drug	drug	PROPN
dti-3495	220	5	target	target	NOUN
dti-3495	220	6	insights	insight	NOUN
dti-3495	220	7	2025	2025	NUM
dti-3495	220	8	;	;	PUNCT
dti-3495	220	9	19	19	NUM
dti-3495	220	10	:	:	SYM
dti-3495	220	11	79	79	NUM
dti-3495	220	12	©	©	ADP
dti-3495	220	13	2025	2025	NUM
dti-3495	220	14	the	the	DET
dti-3495	220	15	authors	author	NOUN
dti-3495	220	16	.	.	PUNCT
dti-3495	221	1	published	publish	VERB
dti-3495	221	2	by	by	ADP
dti-3495	221	3	aboutscience	aboutscience	NOUN
dti-3495	221	4	www.aboutscience.eu	www.aboutscience.eu	NOUN
dti-3495	221	5	functional	functional	ADJ
dti-3495	221	6	annotation	annotation	NOUN
dti-3495	221	7	later	later	ADV
dti-3495	221	8	,	,	PUNCT
dti-3495	221	9	the	the	DET
dti-3495	221	10	functional	functional	ADJ
dti-3495	221	11	annotation	annotation	NOUN
dti-3495	221	12	of	of	ADP
dti-3495	221	13	these	these	DET
dti-3495	221	14	88	88	NUM
dti-3495	221	15	common	common	ADJ
dti-3495	221	16	genes	gene	NOUN
dti-3495	221	17	was	be	AUX
dti-3495	221	18	performed	perform	VERB
dti-3495	221	19	using	use	VERB
dti-3495	221	20	the	the	DET
dti-3495	221	21	david	david	PROPN
dti-3495	221	22	software	software	PROPN
dti-3495	221	23	,	,	PUNCT
dti-3495	221	24	which	which	PRON
dti-3495	221	25	revealed	reveal	VERB
dti-3495	221	26	their	their	PRON
dti-3495	221	27	involvement	involvement	NOUN
dti-3495	221	28	in	in	ADP
dti-3495	221	29	multiple	multiple	ADJ
dti-3495	221	30	diabetes	diabetes	NOUN
dti-3495	221	31	-	-	PUNCT
dti-3495	221	32	related	relate	VERB
dti-3495	221	33	pathways	pathway	NOUN
dti-3495	221	34	.	.	PUNCT
dti-3495	222	1	the	the	DET
dti-3495	222	2	analysis	analysis	NOUN
dti-3495	222	3	identified	identify	VERB
dti-3495	222	4	significant	significant	ADJ
dti-3495	222	5	clusters	cluster	NOUN
dti-3495	222	6	of	of	ADP
dti-3495	222	7	genes	gene	NOUN
dti-3495	222	8	associated	associate	VERB
dti-3495	222	9	with	with	ADP
dti-3495	222	10	key	key	ADJ
dti-3495	222	11	biological	biological	ADJ
dti-3495	222	12	processes	process	NOUN
dti-3495	222	13	(	(	PUNCT
dti-3495	222	14	fig	fig	NOUN
dti-3495	222	15	.	.	PUNCT
dti-3495	222	16	6	6	NUM
dti-3495	222	17	)	)	PUNCT
dti-3495	222	18	,	,	PUNCT
dti-3495	222	19	including	include	VERB
dti-3495	222	20	metabolic	metabolic	NOUN
dti-3495	222	21	pathways	pathway	NOUN
dti-3495	222	22	such	such	ADJ
dti-3495	222	23	as	as	ADP
dti-3495	222	24	prostanoid	prostanoid	NOUN
dti-3495	222	25	and	and	CCONJ
dti-3495	222	26	fatty	fatty	NOUN
dti-3495	222	27	acid	acid	NOUN
dti-3495	222	28	biosynthesis	biosynthesis	NOUN
dti-3495	222	29	.	.	PUNCT
dti-3495	223	1	specifically	specifically	ADV
dti-3495	223	2	,	,	PUNCT
dti-3495	223	3	genes	gene	NOUN
dti-3495	223	4	were	be	AUX
dti-3495	223	5	enriched	enrich	VERB
dti-3495	223	6	in	in	ADP
dti-3495	223	7	processes	process	NOUN
dti-3495	223	8	like	like	ADP
dti-3495	223	9	long	long	ADJ
dti-3495	223	10	-	-	PUNCT
dti-3495	223	11	chain	chain	NOUN
dti-3495	223	12	fatty	fatty	NOUN
dti-3495	223	13	acid	acid	NOUN
dti-3495	223	14	metabolic	metabolic	NOUN
dti-3495	223	15	processes	process	NOUN
dti-3495	223	16	,	,	PUNCT
dti-3495	223	17	organic	organic	ADJ
dti-3495	223	18	acid	acid	NOUN
dti-3495	223	19	biosynthetic	biosynthetic	ADJ
dti-3495	223	20	processes	process	NOUN
dti-3495	223	21	,	,	PUNCT
dti-3495	223	22	and	and	CCONJ
dti-3495	223	23	eicosanoid	eicosanoid	ADJ
dti-3495	223	24	metabolic	metabolic	NOUN
dti-3495	223	25	processes	process	NOUN
dti-3495	223	26	.	.	PUNCT
dti-3495	224	1	additionally	additionally	ADV
dti-3495	224	2	,	,	PUNCT
dti-3495	224	3	another	another	DET
dti-3495	224	4	cluster	cluster	NOUN
dti-3495	224	5	highlighted	highlight	VERB
dti-3495	224	6	the	the	DET
dti-3495	224	7	role	role	NOUN
dti-3495	224	8	of	of	ADP
dti-3495	224	9	these	these	DET
dti-3495	224	10	genes	gene	NOUN
dti-3495	224	11	in	in	ADP
dti-3495	224	12	retinoid	retinoid	PROPN
dti-3495	224	13	metabolic	metabolic	NOUN
dti-3495	224	14	processes	process	NOUN
dti-3495	224	15	and	and	CCONJ
dti-3495	224	16	response	response	NOUN
dti-3495	224	17	to	to	ADP
dti-3495	224	18	retinoic	retinoic	NOUN
dti-3495	224	19	acid	acid	NOUN
dti-3495	224	20	,	,	PUNCT
dti-3495	224	21	emphasizing	emphasize	VERB
dti-3495	224	22	their	their	PRON
dti-3495	224	23	involvement	involvement	NOUN
dti-3495	224	24	in	in	ADP
dti-3495	224	25	important	important	ADJ
dti-3495	224	26	signaling	signal	VERB
dti-3495	224	27	pathways	pathway	NOUN
dti-3495	224	28	.	.	PUNCT
dti-3495	225	1	moreover	moreover	ADV
dti-3495	225	2	,	,	PUNCT
dti-3495	225	3	a	a	DET
dti-3495	225	4	smaller	small	ADJ
dti-3495	225	5	subset	subset	NOUN
dti-3495	225	6	of	of	ADP
dti-3495	225	7	genes	gene	NOUN
dti-3495	225	8	was	be	AUX
dti-3495	225	9	associated	associate	VERB
dti-3495	225	10	with	with	ADP
dti-3495	225	11	oxidoreductase	oxidoreductase	ADJ
dti-3495	225	12	activity	activity	NOUN
dti-3495	225	13	,	,	PUNCT
dti-3495	225	14	particularly	particularly	ADV
dti-3495	225	15	acting	act	VERB
dti-3495	225	16	on	on	ADP
dti-3495	225	17	ch	ch	NOUN
dti-3495	225	18	-	-	PUNCT
dti-3495	225	19	oh	oh	NUM
dti-3495	225	20	groups	group	NOUN
dti-3495	225	21	of	of	ADP
dti-3495	225	22	donors	donor	NOUN
dti-3495	225	23	and	and	CCONJ
dti-3495	225	24	the	the	DET
dti-3495	225	25	incorporation	incorporation	NOUN
dti-3495	225	26	of	of	ADP
dti-3495	225	27	two	two	NUM
dti-3495	225	28	atoms	atom	NOUN
dti-3495	225	29	of	of	ADP
dti-3495	225	30	oxygen	oxygen	NOUN
dti-3495	225	31	,	,	PUNCT
dti-3495	225	32	indicating	indicate	VERB
dti-3495	225	33	their	their	PRON
dti-3495	225	34	role	role	NOUN
dti-3495	225	35	in	in	ADP
dti-3495	225	36	oxidation	oxidation	NOUN
dti-3495	225	37	-	-	PUNCT
dti-3495	225	38	reduction	reduction	NOUN
dti-3495	225	39	processes	process	NOUN
dti-3495	225	40	.	.	PUNCT
dti-3495	226	1	in	in	ADP
dti-3495	226	2	terms	term	NOUN
dti-3495	226	3	of	of	ADP
dti-3495	226	4	molecular	molecular	ADJ
dti-3495	226	5	function	function	NOUN
dti-3495	226	6	,	,	PUNCT
dti-3495	226	7	the	the	DET
dti-3495	226	8	common	common	ADJ
dti-3495	226	9	genes	gene	NOUN
dti-3495	226	10	were	be	AUX
dti-3495	226	11	linked	link	VERB
dti-3495	226	12	to	to	ADP
dti-3495	226	13	activities	activity	NOUN
dti-3495	226	14	such	such	ADJ
dti-3495	226	15	as	as	ADP
dti-3495	226	16	ligand	ligand	NOUN
dti-3495	226	17	-	-	PUNCT
dti-3495	226	18	activated	activate	VERB
dti-3495	226	19	transcription	transcription	NOUN
dti-3495	226	20	factor	factor	NOUN
dti-3495	226	21	activity	activity	NOUN
dti-3495	226	22	and	and	CCONJ
dti-3495	226	23	nuclear	nuclear	ADJ
dti-3495	226	24	receptor	receptor	NOUN
dti-3495	226	25	activity	activity	NOUN
dti-3495	226	26	,	,	PUNCT
dti-3495	226	27	which	which	PRON
dti-3495	226	28	are	be	AUX
dti-3495	226	29	crucial	crucial	ADJ
dti-3495	226	30	for	for	ADP
dti-3495	226	31	regulating	regulate	VERB
dti-3495	226	32	gene	gene	NOUN
dti-3495	226	33	expression	expression	NOUN
dti-3495	226	34	,	,	PUNCT
dti-3495	226	35	particularly	particularly	ADV
dti-3495	226	36	in	in	ADP
dti-3495	226	37	response	response	NOUN
dti-3495	226	38	to	to	ADP
dti-3495	226	39	retinoic	retinoic	NOUN
dti-3495	226	40	acid	acid	NOUN
dti-3495	226	41	.	.	PUNCT
dti-3495	227	1	other	other	ADJ
dti-3495	227	2	identified	identify	VERB
dti-3495	227	3	functions	function	NOUN
dti-3495	227	4	include	include	VERB
dti-3495	227	5	protein	protein	NOUN
dti-3495	227	6	autophosphorylation	autophosphorylation	NOUN
dti-3495	227	7	,	,	PUNCT
dti-3495	227	8	essential	essential	ADJ
dti-3495	227	9	for	for	ADP
dti-3495	227	10	signal	signal	ADJ
dti-3495	227	11	transduction	transduction	NOUN
dti-3495	227	12	,	,	PUNCT
dti-3495	227	13	and	and	CCONJ
dti-3495	227	14	protein	protein	NOUN
dti-3495	227	15	tyrosine	tyrosine	PROPN
dti-3495	227	16	kinase	kinase	PROPN
dti-3495	227	17	activity	activity	PROPN
dti-3495	227	18	,	,	PUNCT
dti-3495	227	19	which	which	PRON
dti-3495	227	20	plays	play	VERB
dti-3495	227	21	a	a	DET
dti-3495	227	22	vital	vital	ADJ
dti-3495	227	23	role	role	NOUN
dti-3495	227	24	in	in	ADP
dti-3495	227	25	various	various	ADJ
dti-3495	227	26	cellular	cellular	ADJ
dti-3495	227	27	signaling	signal	VERB
dti-3495	227	28	pathways	pathway	NOUN
dti-3495	227	29	.	.	PUNCT
dti-3495	228	1	the	the	DET
dti-3495	228	2	go	go	VERB
dti-3495	228	3	analysis	analysis	NOUN
dti-3495	228	4	also	also	ADV
dti-3495	228	5	revealed	reveal	VERB
dti-3495	228	6	that	that	SCONJ
dti-3495	228	7	these	these	DET
dti-3495	228	8	genes	gene	NOUN
dti-3495	228	9	are	be	AUX
dti-3495	228	10	integral	integral	ADJ
dti-3495	228	11	components	component	NOUN
dti-3495	228	12	of	of	ADP
dti-3495	228	13	critical	critical	ADJ
dti-3495	228	14	cellular	cellular	ADJ
dti-3495	228	15	structures	structure	NOUN
dti-3495	228	16	,	,	PUNCT
dti-3495	228	17	such	such	ADJ
dti-3495	228	18	as	as	ADP
dti-3495	228	19	the	the	DET
dti-3495	228	20	schaffer	schaffer	PROPN
dti-3495	228	21	collateral	collateral	PROPN
dti-3495	228	22	-	-	PUNCT
dti-3495	228	23	ca1	ca1	NOUN
dti-3495	228	24	-	-	PUNCT
dti-3495	228	25	ca1	ca1	NOUN
dti-3495	228	26	synapse	synapse	NOUN
dti-3495	228	27	,	,	PUNCT
dti-3495	228	28	highlighting	highlight	VERB
dti-3495	228	29	their	their	PRON
dti-3495	228	30	role	role	NOUN
dti-3495	228	31	in	in	ADP
dti-3495	228	32	synaptic	synaptic	ADJ
dti-3495	228	33	transmission	transmission	NOUN
dti-3495	228	34	and	and	CCONJ
dti-3495	228	35	plasticity	plasticity	NOUN
dti-3495	228	36	in	in	ADP
dti-3495	228	37	the	the	DET
dti-3495	228	38	brain	brain	NOUN
dti-3495	228	39	.	.	PUNCT
dti-3495	229	1	additionally	additionally	ADV
dti-3495	229	2	,	,	PUNCT
dti-3495	229	3	other	other	ADJ
dti-3495	229	4	genes	gene	NOUN
dti-3495	229	5	were	be	AUX
dti-3495	229	6	located	locate	VERB
dti-3495	229	7	in	in	ADP
dti-3495	229	8	the	the	DET
dti-3495	229	9	tertiary	tertiary	ADJ
dti-3495	229	10	granule	granule	NOUN
dti-3495	229	11	lumen	luman	NOUN
dti-3495	229	12	and	and	CCONJ
dti-3495	229	13	the	the	DET
dti-3495	229	14	intrinsic	intrinsic	ADJ
dti-3495	229	15	component	component	NOUN
dti-3495	229	16	of	of	ADP
dti-3495	229	17	the	the	DET
dti-3495	229	18	presynaptic	presynaptic	ADJ
dti-3495	229	19	membrane	membrane	NOUN
dti-3495	229	20	,	,	PUNCT
dti-3495	229	21	emphasizing	emphasize	VERB
dti-3495	229	22	their	their	PRON
dti-3495	229	23	involvement	involvement	NOUN
dti-3495	229	24	in	in	ADP
dti-3495	229	25	neurotransmitter	neurotransmitter	NOUN
dti-3495	229	26	release	release	NOUN
dti-3495	229	27	and	and	CCONJ
dti-3495	229	28	synaptic	synaptic	ADJ
dti-3495	229	29	function	function	NOUN
dti-3495	229	30	.	.	PUNCT
dti-3495	230	1	further	far	ADV
dti-3495	230	2	kegg	kegg	PROPN
dti-3495	230	3	pathway	pathway	NOUN
dti-3495	230	4	analysis	analysis	NOUN
dti-3495	230	5	was	be	AUX
dti-3495	230	6	also	also	ADV
dti-3495	230	7	performed	perform	VERB
dti-3495	230	8	(	(	PUNCT
dti-3495	230	9	fig	fig	NOUN
dti-3495	230	10	.	.	PUNCT
dti-3495	231	1	7	7	NUM
dti-3495	231	2	)	)	PUNCT
dti-3495	231	3	.	.	PUNCT
dti-3495	232	1	one	one	NUM
dti-3495	232	2	of	of	ADP
dti-3495	232	3	the	the	DET
dti-3495	232	4	most	most	ADV
dti-3495	232	5	prominent	prominent	ADJ
dti-3495	232	6	pathways	pathway	NOUN
dti-3495	232	7	identified	identify	VERB
dti-3495	232	8	is	be	AUX
dti-3495	232	9	the	the	DET
dti-3495	232	10	arachidonic	arachidonic	ADJ
dti-3495	232	11	acid	acid	NOUN
dti-3495	232	12	metabolism	metabolism	NOUN
dti-3495	232	13	,	,	PUNCT
dti-3495	232	14	which	which	PRON
dti-3495	232	15	is	be	AUX
dti-3495	232	16	crucial	crucial	ADJ
dti-3495	232	17	for	for	ADP
dti-3495	232	18	the	the	DET
dti-3495	232	19	synthesis	synthesis	NOUN
dti-3495	232	20	of	of	ADP
dti-3495	232	21	bioactive	bioactive	ADJ
dti-3495	232	22	lipid	lipid	NOUN
dti-3495	232	23	mediators	mediator	NOUN
dti-3495	232	24	that	that	PRON
dti-3495	232	25	play	play	VERB
dti-3495	232	26	significant	significant	ADJ
dti-3495	232	27	roles	role	NOUN
dti-3495	232	28	in	in	ADP
dti-3495	232	29	inflammation	inflammation	NOUN
dti-3495	232	30	and	and	CCONJ
dti-3495	232	31	cellular	cellular	ADJ
dti-3495	232	32	signaling	signaling	NOUN
dti-3495	232	33	.	.	PUNCT
dti-3495	233	1	another	another	DET
dti-3495	233	2	critical	critical	ADJ
dti-3495	233	3	pathway	pathway	NOUN
dti-3495	233	4	is	be	AUX
dti-3495	233	5	the	the	DET
dti-3495	233	6	hif-1	hif-1	ADJ
dti-3495	233	7	signaling	signal	VERB
dti-3495	233	8	pathway	pathway	NOUN
dti-3495	233	9	,	,	PUNCT
dti-3495	233	10	which	which	PRON
dti-3495	233	11	is	be	AUX
dti-3495	233	12	essential	essential	ADJ
dti-3495	233	13	for	for	ADP
dti-3495	233	14	cellular	cellular	ADJ
dti-3495	233	15	responses	response	NOUN
dti-3495	233	16	to	to	ADP
dti-3495	233	17	hypoxia	hypoxia	NOUN
dti-3495	233	18	and	and	CCONJ
dti-3495	233	19	is	be	AUX
dti-3495	233	20	often	often	ADV
dti-3495	233	21	implicated	implicate	VERB
dti-3495	233	22	in	in	ADP
dti-3495	233	23	cancer	cancer	NOUN
dti-3495	233	24	progression	progression	NOUN
dti-3495	233	25	.	.	PUNCT
dti-3495	234	1	the	the	DET
dti-3495	234	2	ppar	ppar	NOUN
dti-3495	234	3	signaling	signal	VERB
dti-3495	234	4	pathway	pathway	NOUN
dti-3495	234	5	was	be	AUX
dti-3495	234	6	also	also	ADV
dti-3495	234	7	depicted	depict	VERB
dti-3495	234	8	,	,	PUNCT
dti-3495	234	9	which	which	PRON
dti-3495	234	10	plays	play	VERB
dti-3495	234	11	an	an	DET
dti-3495	234	12	important	important	ADJ
dti-3495	234	13	role	role	NOUN
dti-3495	234	14	in	in	ADP
dti-3495	234	15	regulating	regulate	VERB
dti-3495	234	16	fatty	fatty	NOUN
dti-3495	234	17	acids	acid	NOUN
dti-3495	234	18	and	and	CCONJ
dti-3495	234	19	glucose	glucose	NOUN
dti-3495	234	20	homeostasis	homeostasis	NOUN
dti-3495	234	21	and	and	CCONJ
dti-3495	234	22	is	be	AUX
dti-3495	234	23	relevant	relevant	ADJ
dti-3495	234	24	to	to	ADP
dti-3495	234	25	metabolic	metabolic	NOUN
dti-3495	234	26	diseases	disease	NOUN
dti-3495	234	27	.	.	PUNCT
dti-3495	235	1	it	it	PRON
dti-3495	235	2	also	also	ADV
dti-3495	235	3	marks	mark	VERB
dti-3495	235	4	down	down	ADP
dti-3495	235	5	pathways	pathway	NOUN
dti-3495	235	6	that	that	PRON
dti-3495	235	7	relate	relate	VERB
dti-3495	235	8	to	to	ADP
dti-3495	235	9	particular	particular	ADJ
dti-3495	235	10	diseases	disease	NOUN
dti-3495	235	11	,	,	PUNCT
dti-3495	235	12	for	for	ADP
dti-3495	235	13	example	example	NOUN
dti-3495	235	14	,	,	PUNCT
dti-3495	235	15	non	non	ADJ
dti-3495	235	16	-	-	ADJ
dti-3495	235	17	small	small	ADJ
dti-3495	235	18	cell	cell	NOUN
dti-3495	235	19	lung	lung	NOUN
dti-3495	235	20	cancer	cancer	NOUN
dti-3495	235	21	or	or	CCONJ
dti-3495	235	22	bladder	bladder	NOUN
dti-3495	235	23	cancer	cancer	NOUN
dti-3495	235	24	;	;	PUNCT
dti-3495	235	25	this	this	PRON
dti-3495	235	26	means	mean	VERB
dti-3495	235	27	that	that	SCONJ
dti-3495	235	28	these	these	DET
dti-3495	235	29	genes	gene	NOUN
dti-3495	235	30	are	be	AUX
dti-3495	235	31	involved	involve	VERB
dti-3495	235	32	directly	directly	ADV
dti-3495	235	33	in	in	ADP
dti-3495	235	34	causing	cause	VERB
dti-3495	235	35	these	these	DET
dti-3495	235	36	types	type	NOUN
dti-3495	235	37	of	of	ADP
dti-3495	235	38	cancer	cancer	NOUN
dti-3495	235	39	or	or	CCONJ
dti-3495	235	40	in	in	ADP
dti-3495	235	41	their	their	PRON
dti-3495	235	42	advancement	advancement	NOUN
dti-3495	235	43	.	.	PUNCT
dti-3495	236	1	moreover	moreover	ADV
dti-3495	236	2	,	,	PUNCT
dti-3495	236	3	the	the	DET
dti-3495	236	4	information	information	NOUN
dti-3495	236	5	about	about	ADP
dti-3495	236	6	the	the	DET
dti-3495	236	7	discovered	discover	VERB
dti-3495	236	8	vegf	vegf	NOUN
dti-3495	236	9	signaling	signal	VERB
dti-3495	236	10	pathway	pathway	NOUN
dti-3495	236	11	,	,	PUNCT
dti-3495	236	12	which	which	PRON
dti-3495	236	13	plays	play	VERB
dti-3495	236	14	an	an	DET
dti-3495	236	15	important	important	ADJ
dti-3495	236	16	role	role	NOUN
dti-3495	236	17	in	in	ADP
dti-3495	236	18	the	the	DET
dti-3495	236	19	formation	formation	NOUN
dti-3495	236	20	of	of	ADP
dti-3495	236	21	new	new	ADJ
dti-3495	236	22	blood	blood	NOUN
dti-3495	236	23	vessels	vessel	NOUN
dti-3495	236	24	and	and	CCONJ
dti-3495	236	25	is	be	AUX
dti-3495	236	26	widely	widely	ADV
dti-3495	236	27	used	use	VERB
dti-3495	236	28	in	in	ADP
dti-3495	236	29	cancer	cancer	NOUN
dti-3495	236	30	treatment	treatment	NOUN
dti-3495	236	31	.	.	PUNCT
dti-3495	237	1	other	other	ADJ
dti-3495	237	2	pathways	pathway	NOUN
dti-3495	237	3	under	under	ADP
dti-3495	237	4	study	study	NOUN
dti-3495	237	5	include	include	VERB
dti-3495	237	6	nf	nf	NOUN
dti-3495	237	7	-	-	PUNCT
dti-3495	237	8	kappa	kappa	NOUN
dti-3495	237	9	b	b	PROPN
dti-3495	237	10	signaling	signal	VERB
dti-3495	237	11	,	,	PUNCT
dti-3495	237	12	via	via	ADP
dti-3495	237	13	which	which	PRON
dti-3495	237	14	most	most	ADJ
dti-3495	237	15	immune	immune	ADJ
dti-3495	237	16	responses	response	NOUN
dti-3495	237	17	are	be	AUX
dti-3495	237	18	controlled	control	VERB
dti-3495	237	19	,	,	PUNCT
dti-3495	237	20	th17	th17	PROPN
dti-3495	237	21	cell	cell	NOUN
dti-3495	237	22	differentiation	differentiation	NOUN
dti-3495	237	23	during	during	ADP
dti-3495	237	24	autoimmune	autoimmune	ADJ
dti-3495	237	25	diseases	disease	NOUN
dti-3495	237	26	,	,	PUNCT
dti-3495	237	27	etc	etc	X
dti-3495	237	28	.	.	X
dti-3495	238	1	the	the	DET
dti-3495	238	2	occurrence	occurrence	NOUN
dti-3495	238	3	of	of	ADP
dti-3495	238	4	the	the	DET
dti-3495	238	5	adherens	adheren	NOUN
dti-3495	238	6	junction	junction	NOUN
dti-3495	238	7	pathway	pathway	NOUN
dti-3495	238	8	was	be	AUX
dti-3495	238	9	also	also	ADV
dti-3495	238	10	observed	observe	VERB
dti-3495	238	11	for	for	ADP
dti-3495	238	12	cell	cell	NOUN
dti-3495	238	13	-	-	PUNCT
dti-3495	238	14	cell	cell	NOUN
dti-3495	238	15	adhesion	adhesion	NOUN
dti-3495	238	16	,	,	PUNCT
dti-3495	238	17	underlining	underline	VERB
dti-3495	238	18	the	the	DET
dti-3495	238	19	importance	importance	NOUN
dti-3495	238	20	of	of	ADP
dti-3495	238	21	these	these	DET
dti-3495	238	22	genes	gene	NOUN
dti-3495	238	23	in	in	ADP
dti-3495	238	24	supporting	support	VERB
dti-3495	238	25	the	the	DET
dti-3495	238	26	cell	cell	NOUN
dti-3495	238	27	’s	’s	PART
dti-3495	238	28	structure	structure	NOUN
dti-3495	238	29	.	.	PUNCT
dti-3495	239	1	in	in	ADP
dti-3495	239	2	general	general	ADJ
dti-3495	239	3	,	,	PUNCT
dti-3495	239	4	the	the	DET
dti-3495	239	5	kegg	kegg	NOUN
dti-3495	239	6	pathway	pathway	NOUN
dti-3495	239	7	analysis	analysis	NOUN
dti-3495	239	8	shows	show	VERB
dti-3495	239	9	that	that	SCONJ
dti-3495	239	10	the	the	DET
dti-3495	239	11	common	common	ADJ
dti-3495	239	12	genes	gene	NOUN
dti-3495	239	13	are	be	AUX
dti-3495	239	14	found	find	VERB
dti-3495	239	15	in	in	ADP
dti-3495	239	16	various	various	ADJ
dti-3495	239	17	signaling	signal	VERB
dti-3495	239	18	pathways	pathway	NOUN
dti-3495	239	19	and	and	CCONJ
dti-3495	239	20	biological	biological	ADJ
dti-3495	239	21	processes	process	NOUN
dti-3495	239	22	that	that	PRON
dti-3495	239	23	are	be	AUX
dti-3495	239	24	known	know	VERB
dti-3495	239	25	to	to	PART
dti-3495	239	26	be	be	AUX
dti-3495	239	27	important	important	ADJ
dti-3495	239	28	for	for	ADP
dti-3495	239	29	maintaining	maintain	VERB
dti-3495	239	30	cellular	cellular	ADJ
dti-3495	239	31	homeostasis	homeostasis	NOUN
dti-3495	239	32	and	and	CCONJ
dti-3495	239	33	regulating	regulate	VERB
dti-3495	239	34	metabolic	metabolic	NOUN
dti-3495	239	35	and	and	CCONJ
dti-3495	239	36	disease	disease	NOUN
dti-3495	239	37	processes	process	NOUN
dti-3495	239	38	.	.	PUNCT
dti-3495	240	1	this	this	DET
dti-3495	240	2	type	type	NOUN
dti-3495	240	3	of	of	ADP
dti-3495	240	4	analysis	analysis	NOUN
dti-3495	240	5	is	be	AUX
dti-3495	240	6	helpful	helpful	ADJ
dti-3495	240	7	in	in	ADP
dti-3495	240	8	understanding	understand	VERB
dti-3495	240	9	the	the	DET
dti-3495	240	10	possible	possible	ADJ
dti-3495	240	11	functions	function	NOUN
dti-3495	240	12	of	of	ADP
dti-3495	240	13	these	these	DET
dti-3495	240	14	genes	gene	NOUN
dti-3495	240	15	from	from	ADP
dti-3495	240	16	a	a	DET
dti-3495	240	17	human	human	ADJ
dti-3495	240	18	disease	disease	NOUN
dti-3495	240	19	perspective	perspective	NOUN
dti-3495	240	20	and	and	CCONJ
dti-3495	240	21	might	might	AUX
dti-3495	240	22	inform	inform	VERB
dti-3495	240	23	future	future	ADJ
dti-3495	240	24	directions	direction	NOUN
dti-3495	240	25	on	on	ADP
dti-3495	240	26	treatments	treatment	NOUN
dti-3495	240	27	and	and	CCONJ
dti-3495	240	28	cures	cure	NOUN
dti-3495	240	29	.	.	PUNCT
dti-3495	241	1	apparently	apparently	ADV
dti-3495	241	2	,	,	PUNCT
dti-3495	241	3	the	the	DET
dti-3495	241	4	network	network	NOUN
dti-3495	241	5	representation	representation	NOUN
dti-3495	241	6	strengthens	strengthen	VERB
dti-3495	241	7	the	the	DET
dti-3495	241	8	claims	claim	NOUN
dti-3495	241	9	made	make	VERB
dti-3495	241	10	with	with	ADP
dti-3495	241	11	respect	respect	NOUN
dti-3495	241	12	to	to	PART
dti-3495	241	13	figure	figure	VERB
dti-3495	241	14	5	5	NUM
dti-3495	241	15	network	network	NOUN
dti-3495	241	16	and	and	CCONJ
dti-3495	241	17	target	target	VERB
dti-3495	241	18	analysis	analysis	NOUN
dti-3495	241	19	of	of	ADP
dti-3495	241	20	common	common	ADJ
dti-3495	241	21	genes	gene	NOUN
dti-3495	241	22	.	.	PUNCT
dti-3495	242	1	(	(	PUNCT
dti-3495	242	2	a	a	X
dti-3495	242	3	)	)	PUNCT
dti-3495	242	4	venn	venn	PROPN
dti-3495	242	5	diagram	diagram	PROPN
dti-3495	242	6	showing	show	VERB
dti-3495	242	7	the	the	DET
dti-3495	242	8	overlap	overlap	NOUN
dti-3495	242	9	between	between	ADP
dti-3495	242	10	compoundrelated	compoundrelate	VERB
dti-3495	242	11	targets	target	NOUN
dti-3495	242	12	(	(	PUNCT
dti-3495	242	13	3,186	3,186	NUM
dti-3495	242	14	)	)	PUNCT
dti-3495	242	15	and	and	CCONJ
dti-3495	242	16	disease	disease	NOUN
dti-3495	242	17	-	-	PUNCT
dti-3495	242	18	related	relate	VERB
dti-3495	242	19	targets	target	NOUN
dti-3495	242	20	(	(	PUNCT
dti-3495	242	21	327	327	NUM
dti-3495	242	22	)	)	PUNCT
dti-3495	242	23	,	,	PUNCT
dti-3495	242	24	identifying	identify	VERB
dti-3495	242	25	88	88	NUM
dti-3495	242	26	common	common	ADJ
dti-3495	242	27	genes	gene	NOUN
dti-3495	242	28	.	.	PUNCT
dti-3495	243	1	(	(	PUNCT
dti-3495	243	2	b	b	X
dti-3495	243	3	)	)	PUNCT
dti-3495	243	4	protein	protein	NOUN
dti-3495	243	5	-	-	PUNCT
dti-3495	243	6	protein	protein	NOUN
dti-3495	243	7	interaction	interaction	NOUN
dti-3495	243	8	(	(	PUNCT
dti-3495	243	9	ppi	ppi	NOUN
dti-3495	243	10	)	)	PUNCT
dti-3495	243	11	network	network	NOUN
dti-3495	243	12	of	of	ADP
dti-3495	243	13	the	the	DET
dti-3495	243	14	88	88	NUM
dti-3495	243	15	common	common	ADJ
dti-3495	243	16	genes	gene	NOUN
dti-3495	243	17	,	,	PUNCT
dti-3495	243	18	illustrating	illustrate	VERB
dti-3495	243	19	the	the	DET
dti-3495	243	20	complex	complex	ADJ
dti-3495	243	21	interactions	interaction	NOUN
dti-3495	243	22	among	among	ADP
dti-3495	243	23	these	these	DET
dti-3495	243	24	targets	target	NOUN
dti-3495	243	25	.	.	PUNCT
dti-3495	244	1	(	(	PUNCT
dti-3495	244	2	c	c	X
dti-3495	244	3	)	)	PUNCT
dti-3495	244	4	sub	sub	NOUN
dti-3495	244	5	-	-	NOUN
dti-3495	244	6	network	network	NOUN
dti-3495	244	7	highlighting	highlight	VERB
dti-3495	244	8	the	the	DET
dti-3495	244	9	top	top	ADJ
dti-3495	244	10	10	10	NUM
dti-3495	244	11	genes	gene	NOUN
dti-3495	244	12	based	base	VERB
dti-3495	244	13	on	on	ADP
dti-3495	244	14	degree	degree	NOUN
dti-3495	244	15	of	of	ADP
dti-3495	244	16	connectivity	connectivity	NOUN
dti-3495	244	17	in	in	ADP
dti-3495	244	18	silico	silico	NOUN
dti-3495	244	19	anti	anti	ADJ
dti-3495	244	20	-	-	ADJ
dti-3495	244	21	diabetic	diabetic	ADJ
dti-3495	244	22	potential	potential	NOUN
dti-3495	244	23	of	of	ADP
dti-3495	244	24	vigna	vigna	PROPN
dti-3495	244	25	unguiculata80	unguiculata80	PROPN
dti-3495	245	1	©	©	PROPN
dti-3495	245	2	2025	2025	NUM
dti-3495	246	1	the	the	DET
dti-3495	246	2	authors	author	NOUN
dti-3495	246	3	.	.	PUNCT
dti-3495	247	1	drug	drug	NOUN
dti-3495	247	2	target	target	NOUN
dti-3495	247	3	insights	insight	NOUN
dti-3495	247	4	issn	issn	VERB
dti-3495	247	5	1177	1177	NUM
dti-3495	247	6	-	-	SYM
dti-3495	247	7	3928	3928	NUM
dti-3495	247	8	www.aboutscience.eu/dti	www.aboutscience.eu/dti	NOUN
dti-3495	247	9	figure	figure	NOUN
dti-3495	247	10	6	6	NUM
dti-3495	247	11	gene	gene	NOUN
dti-3495	247	12	ontology	ontology	NOUN
dti-3495	247	13	analysis	analysis	NOUN
dti-3495	247	14	of	of	ADP
dti-3495	247	15	88	88	NUM
dti-3495	247	16	common	common	ADJ
dti-3495	247	17	genes	gene	NOUN
dti-3495	247	18	representing	represent	VERB
dti-3495	247	19	their	their	PRON
dti-3495	247	20	involvement	involvement	NOUN
dti-3495	247	21	in	in	ADP
dti-3495	247	22	multiple	multiple	ADJ
dti-3495	247	23	biological	biological	ADJ
dti-3495	247	24	processes	process	NOUN
dti-3495	247	25	,	,	PUNCT
dti-3495	247	26	cellular	cellular	ADJ
dti-3495	247	27	components	component	NOUN
dti-3495	247	28	,	,	PUNCT
dti-3495	247	29	and	and	CCONJ
dti-3495	247	30	molecular	molecular	ADJ
dti-3495	247	31	functions	function	NOUN
dti-3495	247	32	.	.	PUNCT
dti-3495	248	1	the	the	DET
dti-3495	248	2	connectivity	connectivity	NOUN
dti-3495	248	3	of	of	ADP
dti-3495	248	4	these	these	DET
dti-3495	248	5	genes	gene	NOUN
dti-3495	248	6	in	in	ADP
dti-3495	248	7	the	the	DET
dti-3495	248	8	designated	designate	VERB
dti-3495	248	9	go	go	NOUN
dti-3495	248	10	classes	class	NOUN
dti-3495	248	11	and	and	CCONJ
dti-3495	248	12	proves	prove	VERB
dti-3495	248	13	the	the	DET
dti-3495	248	14	multifaceted	multifaceted	ADJ
dti-3495	248	15	nature	nature	NOUN
dti-3495	248	16	of	of	ADP
dti-3495	248	17	these	these	DET
dti-3495	248	18	genes	gene	NOUN
dti-3495	248	19	in	in	ADP
dti-3495	248	20	terms	term	NOUN
dti-3495	248	21	of	of	ADP
dti-3495	248	22	their	their	PRON
dti-3495	248	23	functions	function	NOUN
dti-3495	248	24	in	in	ADP
dti-3495	248	25	various	various	ADJ
dti-3495	248	26	biological	biological	ADJ
dti-3495	248	27	processes	process	NOUN
dti-3495	248	28	,	,	PUNCT
dti-3495	248	29	molecular	molecular	ADJ
dti-3495	248	30	functions	function	NOUN
dti-3495	248	31	,	,	PUNCT
dti-3495	248	32	and	and	CCONJ
dti-3495	248	33	cellular	cellular	ADJ
dti-3495	248	34	components	component	NOUN
dti-3495	248	35	.	.	PUNCT
dti-3495	249	1	compound	compound	NOUN
dti-3495	249	2	-	-	PUNCT
dti-3495	249	3	target	target	NOUN
dti-3495	249	4	pathway	pathway	NOUN
dti-3495	249	5	network	network	NOUN
dti-3495	249	6	the	the	DET
dti-3495	249	7	compound	compound	NOUN
dti-3495	249	8	-	-	PUNCT
dti-3495	249	9	target	target	NOUN
dti-3495	249	10	pathway	pathway	NOUN
dti-3495	249	11	network	network	NOUN
dti-3495	249	12	analysis	analysis	NOUN
dti-3495	249	13	(	(	PUNCT
dti-3495	249	14	fig	fig	NOUN
dti-3495	249	15	.	.	PUNCT
dti-3495	250	1	8)	8)	NUM
dti-3495	250	2	revealed	reveal	VERB
dti-3495	250	3	that	that	SCONJ
dti-3495	250	4	gsk3b	gsk3b	PROPN
dti-3495	250	5	,	,	PUNCT
dti-3495	250	6	ptgs2	ptgs2	PROPN
dti-3495	250	7	,	,	PUNCT
dti-3495	250	8	and	and	CCONJ
dti-3495	250	9	tlr4	tlr4	NOUN
dti-3495	250	10	are	be	AUX
dti-3495	250	11	the	the	DET
dti-3495	250	12	primary	primary	ADJ
dti-3495	250	13	target	target	NOUN
dti-3495	250	14	proteins	protein	NOUN
dti-3495	250	15	,	,	PUNCT
dti-3495	250	16	displaying	display	VERB
dti-3495	250	17	the	the	DET
dti-3495	250	18	highest	high	ADJ
dti-3495	250	19	connectivity	connectivity	NOUN
dti-3495	250	20	within	within	ADP
dti-3495	250	21	the	the	DET
dti-3495	250	22	network	network	NOUN
dti-3495	250	23	and	and	CCONJ
dti-3495	250	24	interacting	interact	VERB
dti-3495	250	25	with	with	ADP
dti-3495	250	26	the	the	DET
dti-3495	250	27	most	most	ADV
dti-3495	250	28	bioactive	bioactive	ADJ
dti-3495	250	29	compounds	compound	NOUN
dti-3495	250	30	.	.	PUNCT
dti-3495	251	1	the	the	DET
dti-3495	251	2	high	high	ADJ
dti-3495	251	3	degree	degree	NOUN
dti-3495	251	4	of	of	ADP
dti-3495	251	5	connectivity	connectivity	NOUN
dti-3495	251	6	values	value	NOUN
dti-3495	251	7	means	mean	VERB
dti-3495	251	8	that	that	SCONJ
dti-3495	251	9	these	these	DET
dti-3495	251	10	proteins	protein	NOUN
dti-3495	251	11	are	be	AUX
dti-3495	251	12	core	core	NOUN
dti-3495	251	13	to	to	ADP
dti-3495	251	14	the	the	DET
dti-3495	251	15	network	network	NOUN
dti-3495	251	16	and	and	CCONJ
dti-3495	251	17	highlight	highlight	VERB
dti-3495	251	18	them	they	PRON
dti-3495	251	19	as	as	ADP
dti-3495	251	20	potential	potential	ADJ
dti-3495	251	21	targets	target	NOUN
dti-3495	251	22	for	for	ADP
dti-3495	251	23	treatment	treatment	NOUN
dti-3495	251	24	.	.	PUNCT
dti-3495	252	1	furthermore	furthermore	ADV
dti-3495	252	2	,	,	PUNCT
dti-3495	252	3	the	the	DET
dti-3495	252	4	investigation	investigation	NOUN
dti-3495	252	5	also	also	ADV
dti-3495	252	6	pointed	point	VERB
dti-3495	252	7	to	to	ADP
dti-3495	252	8	the	the	DET
dti-3495	252	9	fact	fact	NOUN
dti-3495	252	10	that	that	SCONJ
dti-3495	252	11	many	many	ADJ
dti-3495	252	12	compounds	compound	NOUN
dti-3495	252	13	,	,	PUNCT
dti-3495	252	14	including	include	VERB
dti-3495	252	15	those	those	PRON
dti-3495	252	16	from	from	ADP
dti-3495	252	17	v.	v.	ADP
dti-3495	252	18	unguiculata	unguiculata	PROPN
dti-3495	252	19	,	,	PUNCT
dti-3495	252	20	interact	interact	VERB
dti-3495	252	21	with	with	ADP
dti-3495	252	22	these	these	DET
dti-3495	252	23	proteins	protein	NOUN
dti-3495	252	24	,	,	PUNCT
dti-3495	252	25	making	make	VERB
dti-3495	252	26	them	they	PRON
dti-3495	252	27	valuable	valuable	ADJ
dti-3495	252	28	targets	target	NOUN
dti-3495	252	29	for	for	ADP
dti-3495	252	30	therapeutic	therapeutic	ADJ
dti-3495	252	31	agents	agent	NOUN
dti-3495	252	32	.	.	PUNCT
dti-3495	253	1	notably	notably	ADV
dti-3495	253	2	,	,	PUNCT
dti-3495	253	3	gsk3b	gsk3b	PROPN
dti-3495	253	4	,	,	PUNCT
dti-3495	253	5	ptgs2	ptgs2	PROPN
dti-3495	253	6	,	,	PUNCT
dti-3495	253	7	and	and	CCONJ
dti-3495	253	8	tlr4	tlr4	NOUN
dti-3495	253	9	are	be	AUX
dti-3495	253	10	known	know	VERB
dti-3495	253	11	to	to	PART
dti-3495	253	12	be	be	AUX
dti-3495	253	13	associated	associate	VERB
dti-3495	253	14	with	with	ADP
dti-3495	253	15	type	type	NOUN
dti-3495	253	16	2	2	NUM
dti-3495	253	17	diabetes	diabete	NOUN
dti-3495	253	18	;	;	PUNCT
dti-3495	253	19	gsk3b	gsk3b	PROPN
dti-3495	253	20	was	be	AUX
dti-3495	253	21	reported	report	VERB
dti-3495	253	22	to	to	PART
dti-3495	253	23	be	be	AUX
dti-3495	253	24	a	a	DET
dti-3495	253	25	key	key	ADJ
dti-3495	253	26	protein	protein	NOUN
dti-3495	253	27	regulating	regulate	VERB
dti-3495	253	28	insulin	insulin	NOUN
dti-3495	253	29	signaling	signaling	NOUN
dti-3495	253	30	and	and	CCONJ
dti-3495	253	31	glucose	glucose	NOUN
dti-3495	253	32	homeostasis	homeostasis	NOUN
dti-3495	253	33	,	,	PUNCT
dti-3495	253	34	ptgs2	ptgs2	PROPN
dti-3495	253	35	participates	participate	VERB
dti-3495	253	36	in	in	ADP
dti-3495	253	37	inflammation	inflammation	NOUN
dti-3495	253	38	aggravating	aggravating	ADJ
dti-3495	253	39	insulin	insulin	NOUN
dti-3495	253	40	resistance	resistance	NOUN
dti-3495	253	41	,	,	PUNCT
dti-3495	253	42	and	and	CCONJ
dti-3495	253	43	tlr4	tlr4	NOUN
dti-3495	253	44	was	be	AUX
dti-3495	253	45	reported	report	VERB
dti-3495	253	46	to	to	PART
dti-3495	253	47	be	be	AUX
dti-3495	253	48	involved	involve	VERB
dti-3495	253	49	in	in	ADP
dti-3495	253	50	immune	immune	ADJ
dti-3495	253	51	response	response	NOUN
dti-3495	253	52	and	and	CCONJ
dti-3495	253	53	chronic	chronic	ADJ
dti-3495	253	54	inflammation	inflammation	NOUN
dti-3495	253	55	in	in	ADP
dti-3495	253	56	the	the	DET
dti-3495	253	57	development	development	NOUN
dti-3495	253	58	of	of	ADP
dti-3495	253	59	t2d	t2d	NOUN
dti-3495	253	60	.	.	PUNCT
dti-3495	254	1	these	these	DET
dti-3495	254	2	observations	observation	NOUN
dti-3495	254	3	indicate	indicate	VERB
dti-3495	254	4	that	that	SCONJ
dti-3495	254	5	modulating	modulate	VERB
dti-3495	254	6	the	the	DET
dti-3495	254	7	expression	expression	NOUN
dti-3495	254	8	of	of	ADP
dti-3495	254	9	gsk3b	gsk3b	PROPN
dti-3495	254	10	,	,	PUNCT
dti-3495	254	11	ptgs2	ptgs2	PROPN
dti-3495	254	12	,	,	PUNCT
dti-3495	254	13	and	and	CCONJ
dti-3495	254	14	tlr4	tlr4	NOUN
dti-3495	254	15	using	use	VERB
dti-3495	254	16	the	the	DET
dti-3495	254	17	active	active	ADJ
dti-3495	254	18	compounds	compound	NOUN
dti-3495	254	19	isolated	isolate	VERB
dti-3495	254	20	from	from	ADP
dti-3495	254	21	v.	v.	ADP
dti-3495	254	22	unguiculata	unguiculata	PROPN
dti-3495	254	23	may	may	AUX
dti-3495	254	24	be	be	AUX
dti-3495	254	25	a	a	DET
dti-3495	254	26	potential	potential	ADJ
dti-3495	254	27	therapeutic	therapeutic	ADJ
dti-3495	254	28	approach	approach	NOUN
dti-3495	254	29	for	for	ADP
dti-3495	254	30	type	type	NOUN
dti-3495	254	31	2	2	NUM
dti-3495	254	32	diabetes	diabetes	NOUN
dti-3495	254	33	.	.	PUNCT
dti-3495	255	1	molecular	molecular	ADJ
dti-3495	255	2	docking	docking	NOUN
dti-3495	255	3	analysis	analysis	NOUN
dti-3495	255	4	the	the	DET
dti-3495	255	5	docking	docking	NOUN
dti-3495	255	6	results	result	NOUN
dti-3495	255	7	provide	provide	VERB
dti-3495	255	8	insights	insight	NOUN
dti-3495	255	9	into	into	ADP
dti-3495	255	10	the	the	DET
dti-3495	255	11	binding	bind	VERB
dti-3495	255	12	affinities	affinity	NOUN
dti-3495	255	13	of	of	ADP
dti-3495	255	14	various	various	ADJ
dti-3495	255	15	compounds	compound	NOUN
dti-3495	255	16	with	with	ADP
dti-3495	255	17	three	three	NUM
dti-3495	255	18	target	target	NOUN
dti-3495	255	19	proteins	protein	NOUN
dti-3495	255	20	:	:	PUNCT
dti-3495	255	21	gsk3b	gsk3b	PROPN
dti-3495	255	22	,	,	PUNCT
dti-3495	255	23	tlr4	tlr4	NOUN
dti-3495	255	24	,	,	PUNCT
dti-3495	255	25	and	and	CCONJ
dti-3495	255	26	ptgs2	ptgs2	PROPN
dti-3495	255	27	,	,	PUNCT
dti-3495	255	28	as	as	SCONJ
dti-3495	255	29	shown	show	VERB
dti-3495	255	30	in	in	ADP
dti-3495	255	31	table	table	NOUN
dti-3495	255	32	2	2	NUM
dti-3495	255	33	.	.	PUNCT
dti-3495	256	1	these	these	DET
dti-3495	256	2	interactions	interaction	NOUN
dti-3495	256	3	are	be	AUX
dti-3495	256	4	critical	critical	ADJ
dti-3495	256	5	for	for	ADP
dti-3495	256	6	evaluating	evaluate	VERB
dti-3495	256	7	the	the	DET
dti-3495	256	8	efficacy	efficacy	NOUN
dti-3495	256	9	of	of	ADP
dti-3495	256	10	these	these	DET
dti-3495	256	11	compounds	compound	NOUN
dti-3495	256	12	as	as	ADP
dti-3495	256	13	inhibitors	inhibitor	NOUN
dti-3495	256	14	or	or	CCONJ
dti-3495	256	15	modulators	modulator	NOUN
dti-3495	256	16	of	of	ADP
dti-3495	256	17	these	these	DET
dti-3495	256	18	proteins	protein	NOUN
dti-3495	256	19	.	.	PUNCT
dti-3495	257	1	the	the	DET
dti-3495	257	2	virtual	virtual	ADJ
dti-3495	257	3	screening	screening	NOUN
dti-3495	257	4	results	result	NOUN
dti-3495	257	5	showed	show	VERB
dti-3495	257	6	stigmasterol	stigmasterol	NOUN
dti-3495	257	7	had	have	VERB
dti-3495	257	8	the	the	DET
dti-3495	257	9	highest	high	ADJ
dti-3495	257	10	binding	bind	VERB
dti-3495	257	11	affinity	affinity	NOUN
dti-3495	257	12	with	with	ADP
dti-3495	257	13	the	the	DET
dti-3495	257	14	8av1	8av1	NUM
dti-3495	257	15	(	(	PUNCT
dti-3495	257	16	gsk3b	gsk3b	PROPN
dti-3495	257	17	)	)	PUNCT
dti-3495	257	18	,	,	PUNCT
dti-3495	257	19	luteolin	luteolin	PROPN
dti-3495	257	20	exhibited	exhibit	VERB
dti-3495	257	21	the	the	DET
dti-3495	257	22	highest	high	ADJ
dti-3495	257	23	binding	bind	VERB
dti-3495	257	24	affinity	affinity	NOUN
dti-3495	257	25	with	with	ADP
dti-3495	257	26	the	the	DET
dti-3495	257	27	4ph9	4ph9	NUM
dti-3495	257	28	(	(	PUNCT
dti-3495	257	29	ptgs2	ptgs2	PROPN
dti-3495	257	30	)	)	PUNCT
dti-3495	257	31	,	,	PUNCT
dti-3495	257	32	while	while	SCONJ
dti-3495	257	33	quercetin	quercetin	NOUN
dti-3495	257	34	showed	show	VERB
dti-3495	257	35	the	the	DET
dti-3495	257	36	highest	high	ADJ
dti-3495	257	37	binding	bind	VERB
dti-3495	257	38	energy	energy	NOUN
dti-3495	257	39	with	with	ADP
dti-3495	257	40	the	the	DET
dti-3495	257	41	3fxi	3fxi	PROPN
dti-3495	257	42	(	(	PUNCT
dti-3495	257	43	tlr4	tlr4	PROPN
dti-3495	257	44	)	)	PUNCT
dti-3495	257	45	.	.	PUNCT
dti-3495	258	1	the	the	DET
dti-3495	258	2	ligand	ligand	ADJ
dti-3495	258	3	-	-	PUNCT
dti-3495	258	4	protein	protein	NOUN
dti-3495	258	5	complexes	complex	NOUN
dti-3495	258	6	were	be	AUX
dti-3495	258	7	further	far	ADV
dti-3495	258	8	validated	validate	VERB
dti-3495	258	9	using	use	VERB
dti-3495	258	10	md	md	PROPN
dti-3495	258	11	simulation	simulation	NOUN
dti-3495	258	12	and	and	CCONJ
dti-3495	258	13	binding	bind	VERB
dti-3495	258	14	free	free	ADJ
dti-3495	258	15	energy	energy	NOUN
dti-3495	258	16	calculations	calculation	NOUN
dti-3495	258	17	.	.	PUNCT
dti-3495	259	1	during	during	ADP
dti-3495	259	2	the	the	DET
dti-3495	259	3	virtual	virtual	ADJ
dti-3495	259	4	screening	screening	NOUN
dti-3495	259	5	of	of	ADP
dti-3495	259	6	the	the	DET
dti-3495	259	7	compounds	compound	NOUN
dti-3495	259	8	with	with	ADP
dti-3495	259	9	the	the	DET
dti-3495	259	10	4ph9	4ph9	NOUN
dti-3495	259	11	,	,	PUNCT
dti-3495	259	12	sardar	sardar	PROPN
dti-3495	259	13	et	et	PROPN
dti-3495	259	14	al	al	PROPN
dti-3495	259	15	drug	drug	PROPN
dti-3495	259	16	target	target	NOUN
dti-3495	259	17	insights	insight	NOUN
dti-3495	259	18	2025	2025	NUM
dti-3495	259	19	;	;	PUNCT
dti-3495	259	20	19	19	NUM
dti-3495	259	21	:	:	SYM
dti-3495	259	22	81	81	NUM
dti-3495	259	23	©	©	ADP
dti-3495	259	24	2025	2025	NUM
dti-3495	259	25	the	the	DET
dti-3495	259	26	authors	author	NOUN
dti-3495	259	27	.	.	PUNCT
dti-3495	260	1	published	publish	VERB
dti-3495	260	2	by	by	ADP
dti-3495	260	3	aboutscience	aboutscience	NOUN
dti-3495	260	4	www.aboutscience.eu	www.aboutscience.eu	NOUN
dti-3495	260	5	figure	figure	NOUN
dti-3495	260	6	7	7	NUM
dti-3495	260	7	kegg	kegg	NOUN
dti-3495	260	8	pathway	pathway	NOUN
dti-3495	260	9	analysis	analysis	NOUN
dti-3495	260	10	demonstrating	demonstrate	VERB
dti-3495	260	11	the	the	DET
dti-3495	260	12	involvement	involvement	NOUN
dti-3495	260	13	of	of	ADP
dti-3495	260	14	selected	select	VERB
dti-3495	260	15	genes	gene	NOUN
dti-3495	260	16	in	in	ADP
dti-3495	260	17	diabetes	diabetes	NOUN
dti-3495	260	18	relevant	relevant	ADJ
dti-3495	260	19	pathways	pathway	NOUN
dti-3495	260	20	.	.	PUNCT
dti-3495	261	1	figure	figure	VERB
dti-3495	261	2	8	8	NUM
dti-3495	261	3	compound	compound	NOUN
dti-3495	261	4	-	-	PUNCT
dti-3495	261	5	target	target	NOUN
dti-3495	261	6	pathway	pathway	NOUN
dti-3495	261	7	network	network	NOUN
dti-3495	261	8	.	.	PUNCT
dti-3495	262	1	the	the	DET
dti-3495	262	2	green	green	PROPN
dti-3495	262	3	octagon	octagon	PROPN
dti-3495	262	4	represents	represent	VERB
dti-3495	262	5	the	the	DET
dti-3495	262	6	compound	compound	NOUN
dti-3495	262	7	,	,	PUNCT
dti-3495	262	8	the	the	DET
dti-3495	262	9	red	red	ADJ
dti-3495	262	10	circle	circle	NOUN
dti-3495	262	11	represents	represent	VERB
dti-3495	262	12	the	the	DET
dti-3495	262	13	hub	hub	NOUN
dti-3495	262	14	genes	gene	NOUN
dti-3495	262	15	,	,	PUNCT
dti-3495	262	16	and	and	CCONJ
dti-3495	262	17	the	the	DET
dti-3495	262	18	blue	blue	ADJ
dti-3495	262	19	square	square	NOUN
dti-3495	262	20	represents	represent	VERB
dti-3495	262	21	the	the	DET
dti-3495	262	22	pathways	pathway	NOUN
dti-3495	262	23	targeted	target	VERB
dti-3495	262	24	by	by	ADP
dti-3495	262	25	hub	hub	NOUN
dti-3495	262	26	genes	gene	NOUN
dti-3495	262	27	.	.	PUNCT
dti-3495	263	1	in	in	ADP
dti-3495	263	2	silico	silico	NOUN
dti-3495	263	3	anti	anti	ADJ
dti-3495	263	4	-	-	ADJ
dti-3495	263	5	diabetic	diabetic	ADJ
dti-3495	263	6	potential	potential	NOUN
dti-3495	263	7	of	of	ADP
dti-3495	263	8	vigna	vigna	PROPN
dti-3495	263	9	unguiculata82	unguiculata82	NOUN
dti-3495	263	10	©	©	PROPN
dti-3495	263	11	2025	2025	NUM
dti-3495	263	12	the	the	DET
dti-3495	263	13	authors	author	NOUN
dti-3495	263	14	.	.	PUNCT
dti-3495	264	1	drug	drug	NOUN
dti-3495	264	2	target	target	NOUN
dti-3495	264	3	insights	insight	NOUN
dti-3495	264	4	issn	issn	VERB
dti-3495	264	5	1177	1177	NUM
dti-3495	264	6	-	-	SYM
dti-3495	264	7	3928	3928	NUM
dti-3495	264	8	www.aboutscience.eu/dti	www.aboutscience.eu/dti	VERB
dti-3495	264	9	the	the	DET
dti-3495	264	10	center	center	NOUN
dti-3495	264	11	of	of	ADP
dti-3495	264	12	the	the	DET
dti-3495	264	13	grid	grid	NOUN
dti-3495	264	14	box	box	PROPN
dti-3495	264	15	includes	include	VERB
dti-3495	264	16	x	x	X
dti-3495	264	17	=	=	SYM
dti-3495	264	18	20.685	20.685	NUM
dti-3495	264	19	,	,	PUNCT
dti-3495	264	20	y	y	PROPN
dti-3495	264	21	=	=	PUNCT
dti-3495	264	22	31.547	31.547	NUM
dti-3495	264	23	,	,	PUNCT
dti-3495	264	24	and	and	CCONJ
dti-3495	264	25	z	z	NOUN
dti-3495	264	26	=	=	SYM
dti-3495	264	27	27.584	27.584	NUM
dti-3495	264	28	,	,	PUNCT
dti-3495	264	29	while	while	SCONJ
dti-3495	264	30	the	the	DET
dti-3495	264	31	size	size	NOUN
dti-3495	264	32	of	of	ADP
dti-3495	264	33	the	the	DET
dti-3495	264	34	grid	grid	NOUN
dti-3495	264	35	box	box	PROPN
dti-3495	264	36	includes	include	VERB
dti-3495	264	37	x	x	PUNCT
dti-3495	264	38	=	=	SYM
dti-3495	264	39	80	80	NUM
dti-3495	264	40	,	,	PUNCT
dti-3495	264	41	y	y	PROPN
dti-3495	264	42	=	=	SYM
dti-3495	264	43	102	102	NUM
dti-3495	264	44	,	,	PUNCT
dti-3495	264	45	and	and	CCONJ
dti-3495	264	46	z	z	NOUN
dti-3495	264	47	=	=	SYM
dti-3495	264	48	72	72	NUM
dti-3495	264	49	.	.	PUNCT
dti-3495	265	1	similarly	similarly	ADV
dti-3495	265	2	,	,	PUNCT
dti-3495	265	3	the	the	DET
dti-3495	265	4	virtual	virtual	ADJ
dti-3495	265	5	screening	screening	NOUN
dti-3495	265	6	of	of	ADP
dti-3495	265	7	the	the	DET
dti-3495	265	8	compounds	compound	NOUN
dti-3495	265	9	with	with	ADP
dti-3495	265	10	the	the	DET
dti-3495	265	11	8av1	8av1	NUM
dti-3495	265	12	,	,	PUNCT
dti-3495	265	13	the	the	DET
dti-3495	265	14	center	center	NOUN
dti-3495	265	15	of	of	ADP
dti-3495	265	16	the	the	DET
dti-3495	265	17	grid	grid	PROPN
dti-3495	265	18	box	box	PROPN
dti-3495	265	19	was	be	AUX
dti-3495	265	20	kept	keep	VERB
dti-3495	265	21	as	as	ADP
dti-3495	265	22	x	x	X
dti-3495	265	23	=	=	SYM
dti-3495	265	24	−3.818	−3.818	PROPN
dti-3495	265	25	,	,	PUNCT
dti-3495	265	26	y	y	PROPN
dti-3495	265	27	=	=	PROPN
dti-3495	265	28	0.936	0.936	NUM
dti-3495	265	29	,	,	PUNCT
dti-3495	265	30	and	and	CCONJ
dti-3495	265	31	z	z	NOUN
dti-3495	265	32	=	=	SYM
dti-3495	265	33	−2.868	−2.868	VERB
dti-3495	265	34	,	,	PUNCT
dti-3495	265	35	while	while	SCONJ
dti-3495	265	36	the	the	DET
dti-3495	265	37	size	size	NOUN
dti-3495	265	38	of	of	ADP
dti-3495	265	39	the	the	DET
dti-3495	265	40	grid	grid	NOUN
dti-3495	265	41	box	box	PROPN
dti-3495	265	42	was	be	AUX
dti-3495	265	43	kept	keep	VERB
dti-3495	265	44	as	as	ADP
dti-3495	265	45	x	x	PROPN
dti-3495	265	46	=	=	SYM
dti-3495	265	47	60	60	NUM
dti-3495	265	48	,	,	PUNCT
dti-3495	265	49	y	y	PROPN
dti-3495	265	50	=	=	SYM
dti-3495	265	51	64	64	NUM
dti-3495	265	52	,	,	PUNCT
dti-3495	265	53	and	and	CCONJ
dti-3495	265	54	z	z	NOUN
dti-3495	265	55	=	=	SYM
dti-3495	265	56	72	72	NUM
dti-3495	265	57	.	.	PUNCT
dti-3495	266	1	furthermore	furthermore	ADV
dti-3495	266	2	,	,	PUNCT
dti-3495	266	3	the	the	DET
dti-3495	266	4	virtual	virtual	ADJ
dti-3495	266	5	screening	screening	NOUN
dti-3495	266	6	of	of	ADP
dti-3495	266	7	the	the	DET
dti-3495	266	8	compounds	compound	NOUN
dti-3495	266	9	with	with	ADP
dti-3495	266	10	the	the	DET
dti-3495	266	11	3fxi	3fxi	NOUN
dti-3495	266	12	,	,	PUNCT
dti-3495	266	13	the	the	DET
dti-3495	266	14	center	center	NOUN
dti-3495	266	15	of	of	ADP
dti-3495	266	16	the	the	DET
dti-3495	266	17	grid	grid	PROPN
dti-3495	266	18	box	box	PROPN
dti-3495	266	19	was	be	AUX
dti-3495	266	20	kept	keep	VERB
dti-3495	266	21	as	as	ADP
dti-3495	266	22	x	x	X
dti-3495	266	23	=	=	NOUN
dti-3495	266	24	4.536	4.536	NUM
dti-3495	266	25	,	,	PUNCT
dti-3495	266	26	y	y	PROPN
dti-3495	266	27	=	=	SYM
dti-3495	266	28	−17.363	−17.363	PROPN
dti-3495	266	29	,	,	PUNCT
dti-3495	266	30	and	and	CCONJ
dti-3495	266	31	z	z	NOUN
dti-3495	266	32	=	=	SYM
dti-3495	266	33	20.067	20.067	NUM
dti-3495	266	34	,	,	PUNCT
dti-3495	266	35	while	while	SCONJ
dti-3495	266	36	the	the	DET
dti-3495	266	37	size	size	NOUN
dti-3495	266	38	of	of	ADP
dti-3495	266	39	the	the	DET
dti-3495	266	40	grid	grid	NOUN
dti-3495	266	41	box	box	PROPN
dti-3495	266	42	was	be	AUX
dti-3495	266	43	kept	keep	VERB
dti-3495	266	44	as	as	ADP
dti-3495	266	45	x	x	PROPN
dti-3495	266	46	=	=	SYM
dti-3495	266	47	60	60	NUM
dti-3495	266	48	,	,	PUNCT
dti-3495	266	49	y	y	PROPN
dti-3495	266	50	=	=	SYM
dti-3495	266	51	40	40	NUM
dti-3495	266	52	,	,	PUNCT
dti-3495	266	53	and	and	CCONJ
dti-3495	266	54	z	z	NOUN
dti-3495	266	55	=	=	NOUN
dti-3495	266	56	100	100	NUM
dti-3495	266	57	.	.	PUNCT
dti-3495	267	1	the	the	DET
dti-3495	267	2	molecular	molecular	ADJ
dti-3495	267	3	docking	docking	NOUN
dti-3495	267	4	of	of	ADP
dti-3495	267	5	luteoline	luteoline	NOUN
dti-3495	267	6	with	with	ADP
dti-3495	267	7	the	the	DET
dti-3495	267	8	4ph9	4ph9	NUM
dti-3495	267	9	showed	show	VERB
dti-3495	267	10	three	three	NUM
dti-3495	267	11	hydrogen	hydrogen	NOUN
dti-3495	267	12	bonds	bond	NOUN
dti-3495	267	13	(	(	PUNCT
dti-3495	267	14	asna39	asna39	PROPN
dti-3495	267	15	,	,	PUNCT
dti-3495	267	16	glua466	glua466	PROPN
dti-3495	267	17	,	,	PUNCT
dti-3495	267	18	and	and	CCONJ
dti-3495	267	19	glya136	glya136	PROPN
dti-3495	267	20	)	)	PUNCT
dti-3495	267	21	,	,	PUNCT
dti-3495	267	22	two	two	NUM
dti-3495	267	23	pi	pi	NOUN
dti-3495	267	24	-	-	PUNCT
dti-3495	267	25	alkyl	alkyl	ADJ
dti-3495	267	26	bonds	bond	NOUN
dti-3495	267	27	(	(	PUNCT
dti-3495	267	28	leua153	leua153	X
dti-3495	267	29	and	and	CCONJ
dti-3495	267	30	proa154	proa154	PROPN
dti-3495	267	31	)	)	PUNCT
dti-3495	267	32	,	,	PUNCT
dti-3495	267	33	two	two	NUM
dti-3495	267	34	carbon	carbon	NOUN
dti-3495	267	35	-	-	PUNCT
dti-3495	267	36	hydrogen	hydrogen	NOUN
dti-3495	267	37	bonds	bond	NOUN
dti-3495	267	38	(	(	PUNCT
dti-3495	267	39	cysa47	cysa47	NOUN
dti-3495	267	40	and	and	CCONJ
dti-3495	267	41	arga470	arga470	PROPN
dti-3495	267	42	)	)	PUNCT
dti-3495	267	43	,	,	PUNCT
dti-3495	267	44	and	and	CCONJ
dti-3495	267	45	one	one	NUM
dti-3495	267	46	unfavorable	unfavorable	ADJ
dti-3495	267	47	acceptor	acceptor	NOUN
dti-3495	267	48	-	-	PUNCT
dti-3495	267	49	acceptor	acceptor	NOUN
dti-3495	267	50	bond	bond	NOUN
dti-3495	267	51	(	(	PUNCT
dti-3495	267	52	tyra131	tyra131	PROPN
dti-3495	267	53	)	)	PUNCT
dti-3495	267	54	.	.	PUNCT
dti-3495	268	1	the	the	DET
dti-3495	268	2	molecular	molecular	ADJ
dti-3495	268	3	docking	docking	NOUN
dti-3495	268	4	of	of	ADP
dti-3495	268	5	the	the	DET
dti-3495	268	6	stigmasterol	stigmasterol	NOUN
dti-3495	268	7	with	with	ADP
dti-3495	268	8	the	the	DET
dti-3495	268	9	8av1	8av1	NUM
dti-3495	268	10	showed	show	VERB
dti-3495	268	11	seven	seven	NUM
dti-3495	268	12	pi	pi	ADJ
dti-3495	268	13	-	-	PUNCT
dti-3495	268	14	alkyl	alkyl	ADJ
dti-3495	268	15	bonds	bond	NOUN
dti-3495	268	16	(	(	PUNCT
dti-3495	268	17	ilea37	ilea37	PROPN
dti-3495	268	18	,	,	PUNCT
dti-3495	268	19	tyra109	tyra109	PROPN
dti-3495	268	20	,	,	PUNCT
dti-3495	268	21	leua163	leua163	PROPN
dti-3495	268	22	,	,	PUNCT
dti-3495	268	23	alaa58	alaa58	NOUN
dti-3495	268	24	,	,	PUNCT
dti-3495	268	25	vala45	vala45	NOUN
dti-3495	268	26	,	,	PUNCT
dti-3495	268	27	lysa60	lysa60	PROPN
dti-3495	268	28	,	,	PUNCT
dti-3495	268	29	and	and	CCONJ
dti-3495	268	30	leua153	leua153	PROPN
dti-3495	268	31	)	)	PUNCT
dti-3495	268	32	,	,	PUNCT
dti-3495	268	33	and	and	CCONJ
dti-3495	268	34	one	one	NUM
dti-3495	268	35	carbon	carbon	NOUN
dti-3495	268	36	-	-	PUNCT
dti-3495	268	37	hydrogen	hydrogen	NOUN
dti-3495	268	38	bonds	bond	NOUN
dti-3495	268	39	(	(	PUNCT
dti-3495	268	40	aspa175	aspa175	PROPN
dti-3495	268	41	)	)	PUNCT
dti-3495	268	42	.	.	PUNCT
dti-3495	269	1	the	the	DET
dti-3495	269	2	molecular	molecular	ADJ
dti-3495	269	3	docking	docking	NOUN
dti-3495	269	4	of	of	ADP
dti-3495	269	5	quercetin	quercetin	NOUN
dti-3495	269	6	with	with	ADP
dti-3495	269	7	3fxi	3fxi	PROPN
dti-3495	269	8	showed	show	VERB
dti-3495	269	9	one	one	NUM
dti-3495	269	10	hydrogen	hydrogen	NOUN
dti-3495	269	11	bond	bond	NOUN
dti-3495	269	12	(	(	PUNCT
dti-3495	269	13	lysa204	lysa204	PROPN
dti-3495	269	14	)	)	PUNCT
dti-3495	269	15	,	,	PUNCT
dti-3495	269	16	two	two	NUM
dti-3495	269	17	pi	pi	NOUN
dti-3495	269	18	-	-	PUNCT
dti-3495	269	19	anion	anion	NOUN
dti-3495	269	20	bonds	bond	NOUN
dti-3495	269	21	(	(	PUNCT
dti-3495	269	22	aspa155	aspa155	PROPN
dti-3495	269	23	and	and	CCONJ
dti-3495	269	24	aspa183	aspa183	PROPN
dti-3495	269	25	)	)	PUNCT
dti-3495	269	26	,	,	PUNCT
dti-3495	269	27	one	one	NUM
dti-3495	269	28	carbon	carbon	NOUN
dti-3495	269	29	-	-	PUNCT
dti-3495	269	30	hydrogen	hydrogen	NOUN
dti-3495	269	31	bond	bond	NOUN
dti-3495	269	32	(	(	PUNCT
dti-3495	269	33	hisa153	hisa153	PROPN
dti-3495	269	34	)	)	PUNCT
dti-3495	269	35	,	,	PUNCT
dti-3495	269	36	and	and	CCONJ
dti-3495	269	37	one	one	NUM
dti-3495	269	38	unfavorable	unfavorable	ADJ
dti-3495	269	39	acceptor	acceptor	NOUN
dti-3495	269	40	-	-	PUNCT
dti-3495	269	41	acceptor	acceptor	NOUN
dti-3495	269	42	bond	bond	NOUN
dti-3495	269	43	(	(	PUNCT
dti-3495	269	44	sera183	sera183	PROPN
dti-3495	269	45	)	)	PUNCT
dti-3495	269	46	.	.	PUNCT
dti-3495	270	1	the	the	DET
dti-3495	270	2	molecular	molecular	ADJ
dti-3495	270	3	docking	docking	NOUN
dti-3495	270	4	of	of	ADP
dti-3495	270	5	acarbose	acarbose	NOUN
dti-3495	270	6	was	be	AUX
dti-3495	270	7	conducted	conduct	VERB
dti-3495	270	8	against	against	ADP
dti-3495	270	9	the	the	DET
dti-3495	270	10	8av1	8av1	NUM
dti-3495	270	11	,	,	PUNCT
dti-3495	270	12	3fxi	3fxi	NOUN
dti-3495	270	13	,	,	PUNCT
dti-3495	270	14	and	and	CCONJ
dti-3495	270	15	8av1	8av1	NUM
dti-3495	270	16	,	,	PUNCT
dti-3495	270	17	and	and	CCONJ
dti-3495	270	18	results	result	NOUN
dti-3495	270	19	showed	show	VERB
dti-3495	270	20	that	that	SCONJ
dti-3495	270	21	the	the	DET
dti-3495	270	22	binding	bind	VERB
dti-3495	270	23	energy	energy	NOUN
dti-3495	270	24	of	of	ADP
dti-3495	270	25	acarbose	acarbose	NOUN
dti-3495	270	26	with	with	ADP
dti-3495	270	27	the	the	DET
dti-3495	270	28	8av1	8av1	NUM
dti-3495	270	29	is	be	AUX
dti-3495	270	30	−6.9	−6.9	PROPN
dti-3495	270	31	kcal	kcal	PROPN
dti-3495	270	32	/	/	SYM
dti-3495	270	33	mol	mol	PROPN
dti-3495	270	34	,	,	PUNCT
dti-3495	270	35	with	with	ADP
dti-3495	270	36	3fxi	3fxi	PROPN
dti-3495	270	37	is	be	AUX
dti-3495	270	38	−6.7	−6.7	VERB
dti-3495	270	39	kcal	kcal	PROPN
dti-3495	270	40	/	/	SYM
dti-3495	270	41	mol	mol	PROPN
dti-3495	270	42	,	,	PUNCT
dti-3495	270	43	and	and	CCONJ
dti-3495	270	44	with	with	ADP
dti-3495	270	45	the	the	DET
dti-3495	270	46	4ph9	4ph9	NUM
dti-3495	270	47	is	be	AUX
dti-3495	270	48	−8.9	−8.9	PROPN
dti-3495	270	49	kcal	kcal	PROPN
dti-3495	270	50	/	/	SYM
dti-3495	270	51	mol	mol	PROPN
dti-3495	270	52	.	.	PUNCT
dti-3495	271	1	the	the	DET
dti-3495	271	2	acarbose	acarbose	NOUN
dti-3495	271	3	showed	show	VERB
dti-3495	271	4	the	the	DET
dti-3495	271	5	highest	high	ADJ
dti-3495	271	6	binding	bind	VERB
dti-3495	271	7	energy	energy	NOUN
dti-3495	271	8	against	against	ADP
dti-3495	271	9	the	the	DET
dti-3495	271	10	inflammatory	inflammatory	ADJ
dti-3495	271	11	target	target	NOUN
dti-3495	271	12	,	,	PUNCT
dti-3495	271	13	i.e.	i.e.	X
dti-3495	271	14	,	,	PUNCT
dti-3495	271	15	ptgs2	ptgs2	PROPN
dti-3495	271	16	;	;	PUNCT
dti-3495	271	17	however	however	ADV
dti-3495	271	18	,	,	PUNCT
dti-3495	271	19	against	against	ADP
dti-3495	271	20	the	the	DET
dti-3495	271	21	gsk3b	gsk3b	PROPN
dti-3495	271	22	and	and	CCONJ
dti-3495	271	23	tlr-4	tlr-4	ADP
dti-3495	271	24	,	,	PUNCT
dti-3495	271	25	the	the	DET
dti-3495	271	26	acarbose	acarbose	NOUN
dti-3495	271	27	showed	show	VERB
dti-3495	271	28	lower	low	ADJ
dti-3495	271	29	binding	bind	VERB
dti-3495	271	30	energy	energy	NOUN
dti-3495	271	31	as	as	SCONJ
dti-3495	271	32	compared	compare	VERB
dti-3495	271	33	to	to	ADP
dti-3495	271	34	the	the	DET
dti-3495	271	35	other	other	ADJ
dti-3495	271	36	compounds	compound	NOUN
dti-3495	271	37	table	table	NOUN
dti-3495	271	38	3	3	NUM
dti-3495	271	39	.	.	PUNCT
dti-3495	272	1	the	the	DET
dti-3495	272	2	compounds	compound	NOUN
dti-3495	272	3	and	and	CCONJ
dti-3495	272	4	protein	protein	NOUN
dti-3495	272	5	interactions	interaction	NOUN
dti-3495	272	6	are	be	AUX
dti-3495	272	7	shown	show	VERB
dti-3495	272	8	in	in	ADP
dti-3495	272	9	threedimensional	threedimensional	ADJ
dti-3495	272	10	and	and	CCONJ
dti-3495	272	11	two	two	NUM
dti-3495	272	12	-	-	PUNCT
dti-3495	272	13	dimensional	dimensional	ADJ
dti-3495	272	14	views	view	NOUN
dti-3495	272	15	using	use	VERB
dti-3495	272	16	discovery	discovery	NOUN
dti-3495	272	17	studio	studio	NOUN
dti-3495	272	18	visualizer_16	visualizer_16	NOUN
dti-3495	272	19	(	(	PUNCT
dti-3495	272	20	fig	fig	NOUN
dti-3495	272	21	.	.	PUNCT
dti-3495	273	1	9	9	NUM
dti-3495	273	2	)	)	PUNCT
dti-3495	273	3	.	.	PUNCT
dti-3495	274	1	md	md	PROPN
dti-3495	274	2	simulation	simulation	PROPN
dti-3495	274	3	analysis	analysis	NOUN
dti-3495	274	4	during	during	ADP
dti-3495	274	5	the	the	DET
dti-3495	274	6	entire	entire	ADJ
dti-3495	274	7	100	100	NUM
dti-3495	274	8	ns	ns	NUM
dti-3495	274	9	,	,	PUNCT
dti-3495	274	10	it	it	PRON
dti-3495	274	11	was	be	AUX
dti-3495	274	12	found	find	VERB
dti-3495	274	13	that	that	SCONJ
dti-3495	274	14	all	all	DET
dti-3495	274	15	ligandprotein	ligandprotein	ADJ
dti-3495	274	16	complexes	complex	NOUN
dti-3495	274	17	remained	remain	VERB
dti-3495	274	18	stable	stable	ADJ
dti-3495	274	19	during	during	ADP
dti-3495	274	20	the	the	DET
dti-3495	274	21	simulation	simulation	NOUN
dti-3495	274	22	,	,	PUNCT
dti-3495	274	23	and	and	CCONJ
dti-3495	274	24	no	no	DET
dti-3495	274	25	significant	significant	ADJ
dti-3495	274	26	deviation	deviation	NOUN
dti-3495	274	27	in	in	ADP
dti-3495	274	28	the	the	DET
dti-3495	274	29	structural	structural	ADJ
dti-3495	274	30	conformation	conformation	NOUN
dti-3495	274	31	of	of	ADP
dti-3495	274	32	the	the	DET
dti-3495	274	33	ligand	ligand	ADJ
dti-3495	274	34	-	-	PUNCT
dti-3495	274	35	protein	protein	NOUN
dti-3495	274	36	complex	complex	NOUN
dti-3495	274	37	was	be	AUX
dti-3495	274	38	noticed	notice	VERB
dti-3495	274	39	.	.	PUNCT
dti-3495	275	1	the	the	DET
dti-3495	275	2	ligand	ligand	ADJ
dti-3495	275	3	-	-	PUNCT
dti-3495	275	4	protein	protein	NOUN
dti-3495	275	5	complex	complex	ADJ
dti-3495	275	6	stability	stability	NOUN
dti-3495	275	7	was	be	AUX
dti-3495	275	8	measured	measure	VERB
dti-3495	275	9	using	use	VERB
dti-3495	275	10	various	various	ADJ
dti-3495	275	11	key	key	ADJ
dti-3495	275	12	parameters	parameter	NOUN
dti-3495	275	13	such	such	ADJ
dti-3495	275	14	as	as	ADP
dti-3495	275	15	rmsd	rmsd	NOUN
dti-3495	275	16	,	,	PUNCT
dti-3495	275	17	rmsf	rmsf	NOUN
dti-3495	275	18	,	,	PUNCT
dti-3495	275	19	rog	rog	PROPN
dti-3495	275	20	,	,	PUNCT
dti-3495	275	21	etc	etc	X
dti-3495	275	22	.	.	X
dti-3495	275	23	,	,	PUNCT
dti-3495	275	24	and	and	CCONJ
dti-3495	275	25	it	it	PRON
dti-3495	275	26	was	be	AUX
dti-3495	275	27	noticed	notice	VERB
dti-3495	275	28	that	that	SCONJ
dti-3495	275	29	within	within	ADP
dti-3495	275	30	the	the	DET
dti-3495	275	31	first	first	ADJ
dti-3495	275	32	few	few	ADJ
dti-3495	275	33	ns	ns	ADJ
dti-3495	275	34	,	,	PUNCT
dti-3495	275	35	the	the	DET
dti-3495	275	36	system	system	NOUN
dti-3495	275	37	reached	reach	VERB
dti-3495	275	38	equilibrium	equilibrium	NOUN
dti-3495	275	39	and	and	CCONJ
dti-3495	275	40	thereafter	thereafter	ADV
dti-3495	275	41	remained	remain	VERB
dti-3495	275	42	stable	stable	ADJ
dti-3495	275	43	.	.	PUNCT
dti-3495	276	1	the	the	DET
dti-3495	276	2	rmsd	rmsd	ADJ
dti-3495	276	3	values	value	NOUN
dti-3495	276	4	were	be	AUX
dti-3495	276	5	calculated	calculate	VERB
dti-3495	276	6	to	to	PART
dti-3495	276	7	assess	assess	VERB
dti-3495	276	8	the	the	DET
dti-3495	276	9	convergence	convergence	NOUN
dti-3495	276	10	of	of	ADP
dti-3495	276	11	the	the	DET
dti-3495	276	12	system	system	NOUN
dti-3495	276	13	to	to	ADP
dti-3495	276	14	its	its	PRON
dti-3495	276	15	equilibrium	equilibrium	NOUN
dti-3495	276	16	conformation	conformation	NOUN
dti-3495	276	17	.	.	PUNCT
dti-3495	277	1	during	during	ADP
dti-3495	277	2	the	the	DET
dti-3495	277	3	rmsd	rmsd	ADJ
dti-3495	277	4	calculation	calculation	NOUN
dti-3495	277	5	,	,	PUNCT
dti-3495	277	6	initially	initially	ADV
dti-3495	277	7	,	,	PUNCT
dti-3495	277	8	the	the	DET
dti-3495	277	9	system	system	NOUN
dti-3495	277	10	showed	show	VERB
dti-3495	277	11	deviation	deviation	NOUN
dti-3495	277	12	for	for	ADP
dti-3495	277	13	a	a	DET
dti-3495	277	14	few	few	ADJ
dti-3495	277	15	ns	ns	ADJ
dti-3495	277	16	due	due	ADJ
dti-3495	277	17	to	to	ADP
dti-3495	277	18	thermodynamic	thermodynamic	ADJ
dti-3495	277	19	shock	shock	NOUN
dti-3495	277	20	,	,	PUNCT
dti-3495	277	21	but	but	CCONJ
dti-3495	277	22	thereafter	thereafter	ADV
dti-3495	277	23	,	,	PUNCT
dti-3495	277	24	the	the	DET
dti-3495	277	25	rmsd	rmsd	NOUN
dti-3495	277	26	showed	show	VERB
dti-3495	277	27	no	no	DET
dti-3495	277	28	significant	significant	ADJ
dti-3495	277	29	fluctuations	fluctuation	NOUN
dti-3495	277	30	for	for	ADP
dti-3495	277	31	all	all	DET
dti-3495	277	32	the	the	DET
dti-3495	277	33	complexes	complex	NOUN
dti-3495	277	34	,	,	PUNCT
dti-3495	277	35	as	as	SCONJ
dti-3495	277	36	shown	show	VERB
dti-3495	277	37	in	in	ADP
dti-3495	277	38	figure	figure	NOUN
dti-3495	277	39	10	10	NUM
dti-3495	277	40	.	.	PUNCT
dti-3495	278	1	the	the	DET
dti-3495	278	2	rmsd	rmsd	ADJ
dti-3495	278	3	analysis	analysis	NOUN
dti-3495	278	4	showed	show	VERB
dti-3495	278	5	that	that	SCONJ
dti-3495	278	6	the	the	DET
dti-3495	278	7	average	average	ADJ
dti-3495	278	8	rmsd	rmsd	NOUN
dti-3495	278	9	of	of	ADP
dti-3495	278	10	the	the	DET
dti-3495	278	11	3fxi_quercetin	3fxi_quercetin	NUM
dti-3495	278	12	was	be	AUX
dti-3495	278	13	0.25828	0.25828	NUM
dti-3495	278	14	,	,	PUNCT
dti-3495	278	15	the	the	DET
dti-3495	278	16	average	average	ADJ
dti-3495	278	17	rmsd	rmsd	NOUN
dti-3495	278	18	of	of	ADP
dti-3495	278	19	the	the	DET
dti-3495	278	20	4ph9_luteoline	4ph9_luteoline	NOUN
dti-3495	278	21	was	be	AUX
dti-3495	278	22	0.45871	0.45871	NUM
dti-3495	278	23	,	,	PUNCT
dti-3495	278	24	while	while	SCONJ
dti-3495	278	25	the	the	DET
dti-3495	278	26	average	average	ADJ
dti-3495	278	27	rmsd	rmsd	NOUN
dti-3495	278	28	of	of	ADP
dti-3495	278	29	the	the	DET
dti-3495	278	30	8av1_stigmasterol	8av1_stigmasterol	NOUN
dti-3495	278	31	was	be	AUX
dti-3495	278	32	0.28030	0.28030	NUM
dti-3495	278	33	nm	nm	NOUN
dti-3495	278	34	.	.	PUNCT
dti-3495	279	1	the	the	DET
dti-3495	279	2	rmsf	rmsf	NOUN
dti-3495	279	3	analysis	analysis	NOUN
dti-3495	279	4	was	be	AUX
dti-3495	279	5	conducted	conduct	VERB
dti-3495	279	6	to	to	PART
dti-3495	279	7	study	study	VERB
dti-3495	279	8	the	the	DET
dti-3495	279	9	behavior	behavior	NOUN
dti-3495	279	10	,	,	PUNCT
dti-3495	279	11	i.e.	i.e.	X
dti-3495	279	12	,	,	PUNCT
dti-3495	279	13	flexibility	flexibility	NOUN
dti-3495	279	14	of	of	ADP
dti-3495	279	15	the	the	DET
dti-3495	279	16	individual	individual	ADJ
dti-3495	279	17	amino	amino	NOUN
dti-3495	279	18	acid	acid	NOUN
dti-3495	279	19	of	of	ADP
dti-3495	279	20	the	the	DET
dti-3495	279	21	protein	protein	NOUN
dti-3495	279	22	following	follow	VERB
dti-3495	279	23	binding	bind	VERB
dti-3495	279	24	with	with	ADP
dti-3495	279	25	the	the	DET
dti-3495	279	26	ligand	ligand	NOUN
dti-3495	279	27	.	.	PUNCT
dti-3495	280	1	the	the	DET
dti-3495	280	2	rmsf	rmsf	NOUN
dti-3495	280	3	analysis	analysis	NOUN
dti-3495	280	4	showed	show	VERB
dti-3495	280	5	that	that	SCONJ
dti-3495	280	6	complexes	complex	NOUN
dti-3495	280	7	remain	remain	VERB
dti-3495	280	8	stable	stable	ADJ
dti-3495	280	9	during	during	ADP
dti-3495	280	10	the	the	DET
dti-3495	280	11	simulation	simulation	NOUN
dti-3495	280	12	,	,	PUNCT
dti-3495	280	13	and	and	CCONJ
dti-3495	280	14	no	no	DET
dti-3495	280	15	significant	significant	ADJ
dti-3495	280	16	fluctuations	fluctuation	NOUN
dti-3495	280	17	were	be	AUX
dti-3495	280	18	noticed	notice	VERB
dti-3495	280	19	,	,	PUNCT
dti-3495	280	20	as	as	SCONJ
dti-3495	280	21	shown	show	VERB
dti-3495	280	22	in	in	ADP
dti-3495	280	23	figure	figure	NOUN
dti-3495	280	24	11	11	NUM
dti-3495	280	25	.	.	PUNCT
dti-3495	281	1	the	the	DET
dti-3495	281	2	rmsf	rmsf	NOUN
dti-3495	281	3	analysis	analysis	NOUN
dti-3495	281	4	showed	show	VERB
dti-3495	281	5	that	that	SCONJ
dti-3495	281	6	the	the	DET
dti-3495	281	7	average	average	ADJ
dti-3495	281	8	rmsf	rmsf	NOUN
dti-3495	281	9	of	of	ADP
dti-3495	281	10	the	the	DET
dti-3495	281	11	3fxi_quercetin	3fxi_quercetin	NUM
dti-3495	281	12	was	be	AUX
dti-3495	281	13	0.14277	0.14277	NUM
dti-3495	281	14	,	,	PUNCT
dti-3495	281	15	the	the	DET
dti-3495	281	16	average	average	ADJ
dti-3495	281	17	rmsf	rmsf	NOUN
dti-3495	281	18	of	of	ADP
dti-3495	281	19	the	the	DET
dti-3495	281	20	4ph9_luteoline	4ph9_luteoline	NOUN
dti-3495	281	21	was	be	AUX
dti-3495	281	22	0.10841	0.10841	NUM
dti-3495	281	23	,	,	PUNCT
dti-3495	281	24	while	while	SCONJ
dti-3495	281	25	the	the	DET
dti-3495	281	26	average	average	ADJ
dti-3495	281	27	rmsf	rmsf	NOUN
dti-3495	281	28	of	of	ADP
dti-3495	281	29	the	the	DET
dti-3495	281	30	8av1_stigmasterol	8av1_stigmasterol	NOUN
dti-3495	281	31	was	be	AUX
dti-3495	281	32	0.11547	0.11547	NUM
dti-3495	281	33	nm	nm	NOUN
dti-3495	281	34	.	.	PUNCT
dti-3495	282	1	the	the	DET
dti-3495	282	2	compactness	compactness	NOUN
dti-3495	282	3	of	of	ADP
dti-3495	282	4	the	the	DET
dti-3495	282	5	protein	protein	NOUN
dti-3495	282	6	structure	structure	NOUN
dti-3495	282	7	following	follow	VERB
dti-3495	282	8	ligand	ligand	ADJ
dti-3495	282	9	binding	binding	NOUN
dti-3495	282	10	was	be	AUX
dti-3495	282	11	observed	observe	VERB
dti-3495	282	12	using	use	VERB
dti-3495	282	13	the	the	DET
dti-3495	282	14	radius	radius	NOUN
dti-3495	282	15	of	of	ADP
dti-3495	282	16	gyration	gyration	NOUN
dti-3495	282	17	(	(	PUNCT
dti-3495	282	18	rog	rog	NOUN
dti-3495	282	19	)	)	PUNCT
dti-3495	282	20	.	.	PUNCT
dti-3495	283	1	the	the	DET
dti-3495	283	2	rog	rog	PROPN
dti-3495	283	3	analysis	analysis	NOUN
dti-3495	283	4	showed	show	VERB
dti-3495	283	5	that	that	SCONJ
dti-3495	283	6	the	the	DET
dti-3495	283	7	complexes	complex	NOUN
dti-3495	283	8	remained	remain	VERB
dti-3495	283	9	stable	stable	ADJ
dti-3495	283	10	during	during	ADP
dti-3495	283	11	the	the	DET
dti-3495	283	12	entire	entire	ADJ
dti-3495	283	13	simulation	simulation	NOUN
dti-3495	283	14	,	,	PUNCT
dti-3495	283	15	which	which	PRON
dti-3495	283	16	further	far	ADV
dti-3495	283	17	validated	validate	VERB
dti-3495	283	18	the	the	DET
dti-3495	283	19	results	result	NOUN
dti-3495	283	20	of	of	ADP
dti-3495	283	21	the	the	DET
dti-3495	283	22	rmsd	rmsd	NOUN
dti-3495	283	23	and	and	CCONJ
dti-3495	283	24	rmsf	rmsf	NOUN
dti-3495	283	25	.	.	PUNCT
dti-3495	284	1	minor	minor	ADJ
dti-3495	284	2	fluctuations	fluctuation	NOUN
dti-3495	284	3	have	have	AUX
dti-3495	284	4	been	be	AUX
dti-3495	284	5	observed	observe	VERB
dti-3495	284	6	in	in	ADP
dti-3495	284	7	the	the	DET
dti-3495	284	8	complexes	complex	NOUN
dti-3495	284	9	,	,	PUNCT
dti-3495	284	10	which	which	PRON
dti-3495	284	11	correlate	correlate	VERB
dti-3495	284	12	with	with	ADP
dti-3495	284	13	the	the	DET
dti-3495	284	14	small	small	ADJ
dti-3495	284	15	-	-	PUNCT
dti-3495	284	16	scale	scale	NOUN
dti-3495	284	17	motions	motion	NOUN
dti-3495	284	18	and	and	CCONJ
dti-3495	284	19	conformational	conformational	ADJ
dti-3495	284	20	changes	change	NOUN
dti-3495	284	21	associated	associate	VERB
dti-3495	284	22	with	with	ADP
dti-3495	284	23	the	the	DET
dti-3495	284	24	ligand	ligand	NOUN
dti-3495	284	25	binding	bind	VERB
dti-3495	284	26	with	with	ADP
dti-3495	284	27	proteins	protein	NOUN
dti-3495	284	28	figure	figure	NOUN
dti-3495	284	29	12	12	NUM
dti-3495	284	30	.	.	PUNCT
dti-3495	285	1	the	the	DET
dti-3495	285	2	rog	rog	PROPN
dti-3495	285	3	analysis	analysis	NOUN
dti-3495	285	4	showed	show	VERB
dti-3495	285	5	that	that	SCONJ
dti-3495	285	6	the	the	DET
dti-3495	285	7	average	average	NOUN
dti-3495	285	8	of	of	ADP
dti-3495	285	9	the	the	DET
dti-3495	285	10	3fxi_quercetin	3fxi_quercetin	NUM
dti-3495	285	11	complex	complex	NOUN
dti-3495	285	12	was	be	AUX
dti-3495	285	13	3.1447	3.1447	NUM
dti-3495	285	14	,	,	PUNCT
dti-3495	285	15	the	the	DET
dti-3495	285	16	average	average	ADJ
dti-3495	285	17	rmsf	rmsf	NOUN
dti-3495	285	18	of	of	ADP
dti-3495	285	19	the	the	DET
dti-3495	285	20	4ph9_luteoline	4ph9_luteoline	NOUN
dti-3495	285	21	was	be	AUX
dti-3495	285	22	2.4579	2.4579	NUM
dti-3495	285	23	,	,	PUNCT
dti-3495	285	24	while	while	SCONJ
dti-3495	285	25	the	the	DET
dti-3495	285	26	average	average	PROPN
dti-3495	285	27	rog	rog	NOUN
dti-3495	285	28	of	of	ADP
dti-3495	285	29	the	the	DET
dti-3495	285	30	8av1_stigmasterol	8av1_stigmasterol	NOUN
dti-3495	285	31	was	be	AUX
dti-3495	285	32	2.1969	2.1969	NUM
dti-3495	285	33	nm	nm	NOUN
dti-3495	285	34	.	.	PUNCT
dti-3495	286	1	the	the	DET
dti-3495	286	2	changes	change	NOUN
dti-3495	286	3	in	in	ADP
dti-3495	286	4	the	the	DET
dti-3495	286	5	ligand	ligand	ADJ
dti-3495	286	6	-	-	PUNCT
dti-3495	286	7	protein	protein	NOUN
dti-3495	286	8	complex	complex	ADJ
dti-3495	286	9	surface	surface	NOUN
dti-3495	286	10	following	follow	VERB
dti-3495	286	11	exposure	exposure	NOUN
dti-3495	286	12	to	to	ADP
dti-3495	286	13	the	the	DET
dti-3495	286	14	solvent	solvent	NOUN
dti-3495	286	15	during	during	ADP
dti-3495	286	16	the	the	DET
dti-3495	286	17	100	100	NUM
dti-3495	286	18	ns	ns	NUM
dti-3495	286	19	simulation	simulation	NOUN
dti-3495	286	20	were	be	AUX
dti-3495	286	21	studied	study	VERB
dti-3495	286	22	using	use	VERB
dti-3495	286	23	sasa	sasa	NOUN
dti-3495	286	24	.	.	PUNCT
dti-3495	287	1	table	table	NOUN
dti-3495	287	2	2	2	NUM
dti-3495	287	3	docking	docking	NOUN
dti-3495	287	4	results	result	NOUN
dti-3495	287	5	of	of	ADP
dti-3495	287	6	various	various	ADJ
dti-3495	287	7	compounds	compound	NOUN
dti-3495	287	8	with	with	ADP
dti-3495	287	9	8av1	8av1	NUM
dti-3495	287	10	(	(	PUNCT
dti-3495	287	11	gsk3b	gsk3b	PROPN
dti-3495	287	12	)	)	PUNCT
dti-3495	287	13	,	,	PUNCT
dti-3495	287	14	3fxi	3fxi	PROPN
dti-3495	287	15	(	(	PUNCT
dti-3495	287	16	tlr4	tlr4	PROPN
dti-3495	287	17	)	)	PUNCT
dti-3495	287	18	,	,	PUNCT
dti-3495	287	19	and	and	CCONJ
dti-3495	287	20	4ph9	4ph9	NUM
dti-3495	287	21	(	(	PUNCT
dti-3495	287	22	ptgs2	ptgs2	NOUN
dti-3495	287	23	)	)	PUNCT
dti-3495	287	24	proteins	protein	NOUN
dti-3495	287	25	.	.	PUNCT
dti-3495	288	1	the	the	DET
dti-3495	288	2	table	table	NOUN
dti-3495	288	3	summarizes	summarize	VERB
dti-3495	288	4	the	the	DET
dti-3495	288	5	binding	bind	VERB
dti-3495	288	6	affinities	affinity	NOUN
dti-3495	288	7	(	(	PUNCT
dti-3495	288	8	in	in	ADP
dti-3495	288	9	kcal	kcal	PROPN
dti-3495	288	10	/	/	SYM
dti-3495	288	11	mol	mol	NOUN
dti-3495	288	12	)	)	PUNCT
dti-3495	288	13	compound	compound	NOUN
dti-3495	288	14	name	name	NOUN
dti-3495	288	15	binding	bind	VERB
dti-3495	288	16	affinity	affinity	NOUN
dti-3495	288	17	(	(	PUNCT
dti-3495	288	18	kcal	kcal	NOUN
dti-3495	288	19	/	/	SYM
dti-3495	288	20	mol	mol	NOUN
dti-3495	288	21	)	)	PUNCT
dti-3495	288	22	binding	bind	VERB
dti-3495	288	23	affinity	affinity	NOUN
dti-3495	288	24	(	(	PUNCT
dti-3495	288	25	kcal	kcal	NOUN
dti-3495	288	26	/	/	SYM
dti-3495	288	27	mol	mol	NOUN
dti-3495	288	28	)	)	PUNCT
dti-3495	288	29	binding	bind	VERB
dti-3495	288	30	affinity	affinity	NOUN
dti-3495	288	31	(	(	PUNCT
dti-3495	288	32	kcal	kcal	NOUN
dti-3495	288	33	/	/	SYM
dti-3495	288	34	mol	mol	NOUN
dti-3495	288	35	)	)	PUNCT
dti-3495	288	36	stigmasterol	stigmasterol	NOUN
dti-3495	288	37	−8.854	−8.854	NOUN
dti-3495	288	38	−8.679	−8.679	NUM
dti-3495	288	39	−7.244	−7.244	NOUN
dti-3495	288	40	campesterol	campesterol	NOUN
dti-3495	289	1	−8.833	−8.833	PROPN
dti-3495	289	2	−8.062	−8.062	PRON
dti-3495	289	3	−7.084	−7.084	VERB
dti-3495	289	4	beta	beta	NOUN
dti-3495	289	5	-	-	PUNCT
dti-3495	289	6	sitosterol	sitosterol	NOUN
dti-3495	289	7	−8.739	−8.739	NOUN
dti-3495	289	8	−8.052	−8.052	PRON
dti-3495	289	9	−7.149	−7.149	NOUN
dti-3495	289	10	daidzein	daidzein	ADV
dti-3495	289	11	−8.198	−8.198	PROPN
dti-3495	290	1	−7.088	−7.088	NOUN
dti-3495	290	2	−6.667	−6.667	NOUN
dti-3495	290	3	quercetin	quercetin	NOUN
dti-3495	290	4	−8.146	−8.146	NOUN
dti-3495	290	5	−9.122	−9.122	PROPN
dti-3495	290	6	−7.237	−7.237	PROPN
dti-3495	291	1	apigenin	apigenin	PROPN
dti-3495	291	2	−8	−8	X
dti-3495	291	3	−8.941	−8.941	PUNCT
dti-3495	292	1	−7.066	−7.066	X
dti-3495	292	2	luteolin	luteolin	PROPN
dti-3495	292	3	−7.982	−7.982	VERB
dti-3495	292	4	−9.297	−9.297	PROPN
dti-3495	292	5	−6.885	−6.885	PROPN
dti-3495	292	6	kaempferol	kaempferol	NOUN
dti-3495	292	7	−7.782	−7.782	PROPN
dti-3495	293	1	−8.619	−8.619	PROPN
dti-3495	293	2	−6.732	−6.732	PROPN
dti-3495	293	3	genistein	genistein	PROPN
dti-3495	293	4	−7.685	−7.685	PROPN
dti-3495	293	5	−8.81	−8.81	INTJ
dti-3495	293	6	−6.865	−6.865	PROPN
dti-3495	293	7	glycitein	glycitein	NOUN
dti-3495	293	8	−7.645	−7.645	PROPN
dti-3495	293	9	−7.297	−7.297	PROPN
dti-3495	293	10	−6.864	−6.864	PROPN
dti-3495	293	11	catechin	catechin	NOUN
dti-3495	294	1	−7.637	−7.637	NOUN
dti-3495	294	2	−8.098	−8.098	PROPN
dti-3495	294	3	−7.159	−7.159	PRON
dti-3495	294	4	vicine	vicine	NOUN
dti-3495	294	5	−6.17	−6.17	PROPN
dti-3495	294	6	−7.04	−7.04	PROPN
dti-3495	294	7	−6.479	−6.479	NOUN
dti-3495	294	8	acarbose	acarbose	NOUN
dti-3495	294	9	−6.9	−6.9	PROPN
dti-3495	294	10	−6.7	−6.7	PROPN
dti-3495	295	1	−8.9	−8.9	PROPN
dti-3495	295	2	sardar	sardar	PROPN
dti-3495	295	3	et	et	PROPN
dti-3495	295	4	al	al	PROPN
dti-3495	295	5	drug	drug	PROPN
dti-3495	295	6	target	target	NOUN
dti-3495	295	7	insights	insight	NOUN
dti-3495	295	8	2025	2025	NUM
dti-3495	295	9	;	;	PUNCT
dti-3495	295	10	19	19	NUM
dti-3495	295	11	:	:	SYM
dti-3495	295	12	83	83	NUM
dti-3495	295	13	©	©	ADP
dti-3495	295	14	2025	2025	NUM
dti-3495	295	15	the	the	DET
dti-3495	295	16	authors	author	NOUN
dti-3495	295	17	.	.	PUNCT
dti-3495	296	1	published	publish	VERB
dti-3495	296	2	by	by	ADP
dti-3495	296	3	aboutscience	aboutscience	NOUN
dti-3495	296	4	www.aboutscience.eu	www.aboutscience.eu	NOUN
dti-3495	296	5	initially	initially	ADV
dti-3495	296	6	,	,	PUNCT
dti-3495	296	7	the	the	DET
dti-3495	296	8	sasa	sasa	NOUN
dti-3495	296	9	showed	show	VERB
dti-3495	296	10	minor	minor	ADJ
dti-3495	296	11	fluctuations	fluctuation	NOUN
dti-3495	296	12	,	,	PUNCT
dti-3495	296	13	and	and	CCONJ
dti-3495	296	14	thereafter	thereafter	ADV
dti-3495	296	15	the	the	DET
dti-3495	296	16	complexes	complex	NOUN
dti-3495	296	17	achieved	achieve	VERB
dti-3495	296	18	stability	stability	NOUN
dti-3495	296	19	as	as	SCONJ
dti-3495	296	20	shown	show	VERB
dti-3495	296	21	in	in	ADP
dti-3495	296	22	figure	figure	NOUN
dti-3495	296	23	13	13	NUM
dti-3495	296	24	.	.	PUNCT
dti-3495	297	1	the	the	DET
dti-3495	297	2	hydrogen	hydrogen	NOUN
dti-3495	297	3	bonds	bond	NOUN
dti-3495	297	4	analysis	analysis	NOUN
dti-3495	297	5	was	be	AUX
dti-3495	297	6	conducted	conduct	VERB
dti-3495	297	7	during	during	ADP
dti-3495	297	8	the	the	DET
dti-3495	297	9	entire	entire	ADJ
dti-3495	297	10	simulation	simulation	NOUN
dti-3495	297	11	to	to	PART
dti-3495	297	12	study	study	VERB
dti-3495	297	13	the	the	DET
dti-3495	297	14	stability	stability	NOUN
dti-3495	297	15	of	of	ADP
dti-3495	297	16	ligand	ligand	ADJ
dti-3495	297	17	-	-	PUNCT
dti-3495	297	18	protein	protein	NOUN
dti-3495	297	19	complexes	complex	NOUN
dti-3495	297	20	.	.	PUNCT
dti-3495	298	1	the	the	DET
dti-3495	298	2	number	number	NOUN
dti-3495	298	3	of	of	ADP
dti-3495	298	4	hydrogen	hydrogen	NOUN
dti-3495	298	5	bonds	bond	NOUN
dti-3495	298	6	fluctuated	fluctuate	VERB
dti-3495	298	7	for	for	ADP
dti-3495	298	8	all	all	DET
dti-3495	298	9	complexes	complex	NOUN
dti-3495	298	10	during	during	ADP
dti-3495	298	11	the	the	DET
dti-3495	298	12	course	course	NOUN
dti-3495	298	13	of	of	ADP
dti-3495	298	14	the	the	DET
dti-3495	298	15	simulation	simulation	NOUN
dti-3495	298	16	;	;	PUNCT
dti-3495	298	17	however	however	ADV
dti-3495	298	18	,	,	PUNCT
dti-3495	298	19	the	the	DET
dti-3495	298	20	maximum	maximum	ADJ
dti-3495	298	21	number	number	NOUN
dti-3495	298	22	of	of	ADP
dti-3495	298	23	hydrogen	hydrogen	NOUN
dti-3495	298	24	bonds	bond	NOUN
dti-3495	298	25	was	be	AUX
dti-3495	298	26	retained	retain	VERB
dti-3495	298	27	during	during	ADP
dti-3495	298	28	the	the	DET
dti-3495	298	29	simulation	simulation	NOUN
dti-3495	298	30	,	,	PUNCT
dti-3495	298	31	as	as	SCONJ
dti-3495	298	32	shown	show	VERB
dti-3495	298	33	in	in	ADP
dti-3495	298	34	figure	figure	NOUN
dti-3495	298	35	14	14	NUM
dti-3495	298	36	.	.	PUNCT
dti-3495	299	1	binding	bind	VERB
dti-3495	299	2	free	free	ADJ
dti-3495	299	3	energy	energy	NOUN
dti-3495	299	4	parameters	parameter	NOUN
dti-3495	299	5	the	the	DET
dti-3495	299	6	mm	mm	NOUN
dti-3495	299	7	-	-	PUNCT
dti-3495	299	8	pbsa	pbsa	NOUN
dti-3495	299	9	and	and	CCONJ
dti-3495	299	10	mm	mm	NOUN
dti-3495	299	11	-	-	PUNCT
dti-3495	299	12	gbsa	gbsa	ADJ
dti-3495	299	13	analyses	analysis	NOUN
dti-3495	299	14	were	be	AUX
dti-3495	299	15	performed	perform	VERB
dti-3495	299	16	for	for	ADP
dti-3495	299	17	all	all	DET
dti-3495	299	18	the	the	DET
dti-3495	299	19	complexes	complex	NOUN
dti-3495	299	20	to	to	PART
dti-3495	299	21	determine	determine	VERB
dti-3495	299	22	their	their	PRON
dti-3495	299	23	stability	stability	NOUN
dti-3495	299	24	in	in	ADP
dti-3495	299	25	terms	term	NOUN
dti-3495	299	26	of	of	ADP
dti-3495	299	27	binding	bind	VERB
dti-3495	299	28	energy	energy	NOUN
dti-3495	299	29	.	.	PUNCT
dti-3495	300	1	during	during	ADP
dti-3495	300	2	the	the	DET
dti-3495	300	3	binding	binding	ADJ
dti-3495	300	4	free	free	ADJ
dti-3495	300	5	energy	energy	NOUN
dti-3495	300	6	calculations	calculation	NOUN
dti-3495	300	7	of	of	ADP
dti-3495	300	8	the	the	DET
dti-3495	300	9	8av1_stigmastrol	8av1_stigmastrol	NOUN
dti-3495	300	10	using	use	VERB
dti-3495	300	11	mm	mm	NOUN
dti-3495	300	12	-	-	PUNCT
dti-3495	300	13	pbsa	pbsa	NOUN
dti-3495	300	14	revealed	reveal	VERB
dti-3495	300	15	that	that	SCONJ
dti-3495	300	16	the	the	DET
dti-3495	300	17	van	van	PROPN
dti-3495	300	18	der	der	NOUN
dti-3495	300	19	waals	waal	NOUN
dti-3495	300	20	energy	energy	NOUN
dti-3495	300	21	,	,	PUNCT
dti-3495	300	22	eel	eel	NOUN
dti-3495	300	23	,	,	PUNCT
dti-3495	300	24	enpolar	enpolar	ADJ
dti-3495	300	25	,	,	PUNCT
dti-3495	300	26	and	and	CCONJ
dti-3495	300	27	ggas	gga	NOUN
dti-3495	300	28	remain	remain	VERB
dti-3495	300	29	negative	negative	ADJ
dti-3495	300	30	and	and	CCONJ
dti-3495	300	31	exhibited	exhibit	VERB
dti-3495	300	32	favorable	favorable	ADJ
dti-3495	300	33	binding	binding	ADJ
dti-3495	300	34	energy	energy	NOUN
dti-3495	300	35	.	.	PUNCT
dti-3495	301	1	however	however	ADV
dti-3495	301	2	,	,	PUNCT
dti-3495	301	3	epb	epb	PROPN
dti-3495	301	4	energy	energy	NOUN
dti-3495	301	5	and	and	CCONJ
dti-3495	301	6	gsolv	gsolv	ADJ
dti-3495	301	7	energy	energy	NOUN
dti-3495	301	8	of	of	ADP
dti-3495	301	9	the	the	DET
dti-3495	301	10	system	system	NOUN
dti-3495	301	11	remain	remain	VERB
dti-3495	301	12	positive	positive	ADJ
dti-3495	301	13	and	and	CCONJ
dti-3495	301	14	indicate	indicate	VERB
dti-3495	301	15	unfavorable	unfavorable	ADJ
dti-3495	301	16	binding	binding	ADJ
dti-3495	301	17	free	free	ADJ
dti-3495	301	18	energy	energy	NOUN
dti-3495	301	19	.	.	PUNCT
dti-3495	302	1	however	however	ADV
dti-3495	302	2	,	,	PUNCT
dti-3495	302	3	the	the	DET
dti-3495	302	4	total	total	ADJ
dti-3495	302	5	energy	energy	NOUN
dti-3495	302	6	of	of	ADP
dti-3495	302	7	the	the	DET
dti-3495	302	8	system	system	NOUN
dti-3495	302	9	remains	remain	VERB
dti-3495	302	10	negative	negative	ADJ
dti-3495	302	11	and	and	CCONJ
dti-3495	302	12	indicates	indicate	VERB
dti-3495	302	13	favorable	favorable	ADJ
dti-3495	302	14	binding	binding	ADJ
dti-3495	302	15	energy	energy	NOUN
dti-3495	302	16	,	,	PUNCT
dti-3495	302	17	as	as	SCONJ
dti-3495	302	18	shown	show	VERB
dti-3495	302	19	in	in	ADP
dti-3495	302	20	table	table	NOUN
dti-3495	302	21	3	3	NUM
dti-3495	302	22	and	and	CCONJ
dti-3495	302	23	supplementary	supplementary	ADJ
dti-3495	302	24	figure	figure	NOUN
dti-3495	302	25	1	1	NUM
dti-3495	302	26	.	.	PUNCT
dti-3495	302	27	similarly	similarly	ADV
dti-3495	302	28	,	,	PUNCT
dti-3495	302	29	the	the	DET
dti-3495	302	30	mm	mm	NOUN
dti-3495	302	31	-	-	PUNCT
dti-3495	302	32	pbsa	pbsa	NOUN
dti-3495	302	33	results	result	NOUN
dti-3495	302	34	were	be	AUX
dti-3495	302	35	validated	validate	VERB
dti-3495	302	36	using	use	VERB
dti-3495	302	37	the	the	DET
dti-3495	302	38	mm	mm	NOUN
dti-3495	302	39	-	-	PUNCT
dti-3495	302	40	gbsa	gbsa	ADJ
dti-3495	302	41	analysis	analysis	NOUN
dti-3495	302	42	.	.	PUNCT
dti-3495	303	1	during	during	ADP
dti-3495	303	2	the	the	DET
dti-3495	303	3	binding	binding	ADJ
dti-3495	303	4	free	free	ADJ
dti-3495	303	5	energy	energy	NOUN
dti-3495	303	6	calculations	calculation	NOUN
dti-3495	303	7	of	of	ADP
dti-3495	303	8	the	the	DET
dti-3495	303	9	8av1	8av1	NUM
dti-3495	303	10	_	_	PRON
dti-3495	303	11	stigmastrol	stigmastrol	NOUN
dti-3495	303	12	using	use	VERB
dti-3495	303	13	mm	mm	PROPN
dti-3495	303	14	-	-	PUNCT
dti-3495	303	15	gbsa	gbsa	PROPN
dti-3495	303	16	revealed	reveal	VERB
dti-3495	303	17	that	that	SCONJ
dti-3495	303	18	the	the	DET
dti-3495	303	19	van	van	PROPN
dti-3495	303	20	der	der	NOUN
dti-3495	303	21	waals	waal	NOUN
dti-3495	303	22	energy	energy	NOUN
dti-3495	303	23	,	,	PUNCT
dti-3495	303	24	eel	eel	NOUN
dti-3495	303	25	,	,	PUNCT
dti-3495	303	26	esurf	esurf	NOUN
dti-3495	303	27	,	,	PUNCT
dti-3495	303	28	and	and	CCONJ
dti-3495	303	29	ggas	gga	NOUN
dti-3495	303	30	remain	remain	VERB
dti-3495	303	31	negative	negative	ADJ
dti-3495	303	32	and	and	CCONJ
dti-3495	303	33	exhibited	exhibit	VERB
dti-3495	303	34	favorable	favorable	ADJ
dti-3495	303	35	binding	binding	ADJ
dti-3495	303	36	energy	energy	NOUN
dti-3495	303	37	.	.	PUNCT
dti-3495	304	1	however	however	ADV
dti-3495	304	2	,	,	PUNCT
dti-3495	304	3	the	the	DET
dti-3495	304	4	egb	egb	NOUN
dti-3495	304	5	energy	energy	NOUN
dti-3495	304	6	and	and	CCONJ
dti-3495	304	7	gsolv	gsolv	ADJ
dti-3495	304	8	energy	energy	NOUN
dti-3495	304	9	of	of	ADP
dti-3495	304	10	the	the	DET
dti-3495	304	11	system	system	NOUN
dti-3495	304	12	remain	remain	VERB
dti-3495	304	13	positive	positive	ADJ
dti-3495	304	14	and	and	CCONJ
dti-3495	304	15	indicate	indicate	VERB
dti-3495	304	16	unfavorable	unfavorable	ADJ
dti-3495	304	17	binding	binding	ADJ
dti-3495	304	18	free	free	ADJ
dti-3495	304	19	energy	energy	NOUN
dti-3495	304	20	.	.	PUNCT
dti-3495	305	1	however	however	ADV
dti-3495	305	2	,	,	PUNCT
dti-3495	305	3	the	the	DET
dti-3495	305	4	total	total	ADJ
dti-3495	305	5	energy	energy	NOUN
dti-3495	305	6	of	of	ADP
dti-3495	305	7	the	the	DET
dti-3495	305	8	system	system	NOUN
dti-3495	305	9	is	be	AUX
dti-3495	305	10	negative	negative	ADJ
dti-3495	305	11	and	and	CCONJ
dti-3495	305	12	indicates	indicate	VERB
dti-3495	305	13	favorable	favorable	ADJ
dti-3495	305	14	binding	binding	ADJ
dti-3495	305	15	energy	energy	NOUN
dti-3495	305	16	,	,	PUNCT
dti-3495	305	17	as	as	SCONJ
dti-3495	305	18	shown	show	VERB
dti-3495	305	19	in	in	ADP
dti-3495	305	20	table	table	NOUN
dti-3495	305	21	4	4	NUM
dti-3495	305	22	and	and	CCONJ
dti-3495	305	23	supplementary	supplementary	ADJ
dti-3495	305	24	figure	figure	NOUN
dti-3495	305	25	2	2	NUM
dti-3495	305	26	.	.	PUNCT
dti-3495	306	1	the	the	DET
dti-3495	306	2	mm	mm	NOUN
dti-3495	306	3	-	-	PUNCT
dti-3495	306	4	pbsa	pbsa	NOUN
dti-3495	306	5	and	and	CCONJ
dti-3495	306	6	mm	mm	NOUN
dti-3495	306	7	-	-	PUNCT
dti-3495	306	8	gbsa	gbsa	ADJ
dti-3495	306	9	analyses	analysis	NOUN
dti-3495	306	10	were	be	AUX
dti-3495	306	11	performed	perform	VERB
dti-3495	306	12	for	for	ADP
dti-3495	306	13	all	all	DET
dti-3495	306	14	the	the	DET
dti-3495	306	15	complexes	complex	NOUN
dti-3495	306	16	to	to	PART
dti-3495	306	17	determine	determine	VERB
dti-3495	306	18	their	their	PRON
dti-3495	306	19	stability	stability	NOUN
dti-3495	306	20	in	in	ADP
dti-3495	306	21	terms	term	NOUN
dti-3495	306	22	of	of	ADP
dti-3495	306	23	binding	bind	VERB
dti-3495	306	24	energy	energy	NOUN
dti-3495	306	25	.	.	PUNCT
dti-3495	307	1	during	during	ADP
dti-3495	307	2	the	the	DET
dti-3495	307	3	binding	binding	ADJ
dti-3495	307	4	free	free	ADJ
dti-3495	307	5	energy	energy	NOUN
dti-3495	307	6	calculations	calculation	NOUN
dti-3495	307	7	of	of	ADP
dti-3495	307	8	the	the	DET
dti-3495	307	9	4ph9_luteoline	4ph9_luteoline	NOUN
dti-3495	307	10	using	use	VERB
dti-3495	307	11	mm	mm	NOUN
dti-3495	307	12	-	-	PUNCT
dti-3495	307	13	pbsa	pbsa	NOUN
dti-3495	307	14	revealed	reveal	VERB
dti-3495	307	15	that	that	SCONJ
dti-3495	307	16	the	the	DET
dti-3495	307	17	van	van	PROPN
dti-3495	307	18	der	der	NOUN
dti-3495	307	19	waals	waal	NOUN
dti-3495	307	20	energy	energy	NOUN
dti-3495	307	21	,	,	PUNCT
dti-3495	307	22	eel	eel	NOUN
dti-3495	307	23	,	,	PUNCT
dti-3495	307	24	enpolar	enpolar	ADJ
dti-3495	307	25	,	,	PUNCT
dti-3495	307	26	and	and	CCONJ
dti-3495	307	27	ggas	gga	NOUN
dti-3495	307	28	remain	remain	VERB
dti-3495	307	29	negative	negative	ADJ
dti-3495	307	30	and	and	CCONJ
dti-3495	307	31	exhibited	exhibit	VERB
dti-3495	307	32	favorable	favorable	ADJ
dti-3495	307	33	binding	binding	ADJ
dti-3495	307	34	energy	energy	NOUN
dti-3495	307	35	.	.	PUNCT
dti-3495	308	1	however	however	ADV
dti-3495	308	2	,	,	PUNCT
dti-3495	308	3	epb	epb	PROPN
dti-3495	308	4	energy	energy	NOUN
dti-3495	308	5	and	and	CCONJ
dti-3495	308	6	gsolv	gsolv	ADJ
dti-3495	308	7	energy	energy	NOUN
dti-3495	308	8	of	of	ADP
dti-3495	308	9	the	the	DET
dti-3495	308	10	system	system	NOUN
dti-3495	308	11	remains	remain	VERB
dti-3495	308	12	positive	positive	ADJ
dti-3495	308	13	and	and	CCONJ
dti-3495	308	14	indicate	indicate	VERB
dti-3495	308	15	unfavorable	unfavorable	ADJ
dti-3495	308	16	binding	binding	ADJ
dti-3495	308	17	free	free	ADJ
dti-3495	308	18	energy	energy	NOUN
dti-3495	308	19	.	.	PUNCT
dti-3495	309	1	however	however	ADV
dti-3495	309	2	,	,	PUNCT
dti-3495	309	3	the	the	DET
dti-3495	309	4	total	total	ADJ
dti-3495	309	5	energy	energy	NOUN
dti-3495	309	6	of	of	ADP
dti-3495	309	7	the	the	DET
dti-3495	309	8	system	system	NOUN
dti-3495	309	9	remains	remain	VERB
dti-3495	309	10	negative	negative	ADJ
dti-3495	309	11	and	and	CCONJ
dti-3495	309	12	indicates	indicate	VERB
dti-3495	309	13	favorable	favorable	ADJ
dti-3495	309	14	binding	bind	VERB
dti-3495	309	15	figure	figure	NOUN
dti-3495	309	16	9	9	NUM
dti-3495	309	17	molecular	molecular	ADJ
dti-3495	309	18	docking	docking	NOUN
dti-3495	309	19	analysis	analysis	NOUN
dti-3495	309	20	of	of	ADP
dti-3495	309	21	key	key	ADJ
dti-3495	309	22	compounds	compound	NOUN
dti-3495	309	23	with	with	ADP
dti-3495	309	24	target	target	NOUN
dti-3495	309	25	proteins	protein	NOUN
dti-3495	309	26	tlr4	tlr4	NOUN
dti-3495	309	27	(	(	PUNCT
dti-3495	309	28	3fx1	3fx1	NUM
dti-3495	309	29	)	)	PUNCT
dti-3495	309	30	,	,	PUNCT
dti-3495	309	31	ptgs2	ptgs2	X
dti-3495	309	32	(	(	PUNCT
dti-3495	309	33	4ph9	4ph9	NUM
dti-3495	309	34	)	)	PUNCT
dti-3495	309	35	,	,	PUNCT
dti-3495	309	36	and	and	CCONJ
dti-3495	309	37	gsk3b	gsk3b	PROPN
dti-3495	309	38	(	(	PUNCT
dti-3495	309	39	8av1	8av1	NUM
dti-3495	309	40	)	)	PUNCT
dti-3495	309	41	.	.	PUNCT
dti-3495	310	1	based	base	VERB
dti-3495	310	2	on	on	ADP
dti-3495	310	3	the	the	DET
dti-3495	310	4	virtual	virtual	ADJ
dti-3495	310	5	screening	screening	NOUN
dti-3495	310	6	,	,	PUNCT
dti-3495	310	7	stigmasterol	stigmasterol	NOUN
dti-3495	310	8	showed	show	VERB
dti-3495	310	9	binding	binding	ADJ
dti-3495	310	10	affinity	affinity	NOUN
dti-3495	310	11	with	with	ADP
dti-3495	310	12	the	the	DET
dti-3495	310	13	gsk3b	gsk3b	PROPN
dti-3495	310	14	,	,	PUNCT
dti-3495	310	15	luteoline	luteoline	PROPN
dti-3495	310	16	exhibited	exhibit	VERB
dti-3495	310	17	the	the	DET
dti-3495	310	18	highest	high	ADJ
dti-3495	310	19	binding	bind	VERB
dti-3495	310	20	energy	energy	NOUN
dti-3495	310	21	with	with	ADP
dti-3495	310	22	the	the	DET
dti-3495	310	23	ptgs2	ptgs2	NOUN
dti-3495	310	24	,	,	PUNCT
dti-3495	310	25	and	and	CCONJ
dti-3495	310	26	quercetin	quercetin	NOUN
dti-3495	310	27	showed	show	VERB
dti-3495	310	28	the	the	DET
dti-3495	310	29	highest	high	ADJ
dti-3495	310	30	binding	bind	VERB
dti-3495	310	31	energy	energy	NOUN
dti-3495	310	32	with	with	ADP
dti-3495	310	33	the	the	DET
dti-3495	310	34	tlr4	tlr4	NOUN
dti-3495	310	35	.	.	PUNCT
dti-3495	311	1	the	the	DET
dti-3495	311	2	interaction	interaction	NOUN
dti-3495	311	3	of	of	ADP
dti-3495	311	4	the	the	DET
dti-3495	311	5	ligands	ligand	NOUN
dti-3495	311	6	with	with	ADP
dti-3495	311	7	the	the	DET
dti-3495	311	8	target	target	NOUN
dti-3495	311	9	proteins	protein	NOUN
dti-3495	311	10	was	be	AUX
dti-3495	311	11	presented	present	VERB
dti-3495	311	12	in	in	ADP
dti-3495	311	13	two	two	NUM
dti-3495	311	14	-	-	PUNCT
dti-3495	311	15	dimensional	dimensional	ADJ
dti-3495	311	16	and	and	CCONJ
dti-3495	311	17	three	three	NUM
dti-3495	311	18	-	-	PUNCT
dti-3495	311	19	dimensional	dimensional	ADJ
dti-3495	311	20	views	view	NOUN
dti-3495	311	21	using	use	VERB
dti-3495	311	22	discovery	discovery	NOUN
dti-3495	311	23	studio	studio	NOUN
dti-3495	311	24	visualizer	visualizer	NOUN
dti-3495	311	25	.	.	PUNCT
dti-3495	312	1	in	in	ADP
dti-3495	312	2	silico	silico	NOUN
dti-3495	312	3	anti	anti	ADJ
dti-3495	312	4	-	-	ADJ
dti-3495	312	5	diabetic	diabetic	ADJ
dti-3495	312	6	potential	potential	NOUN
dti-3495	312	7	of	of	ADP
dti-3495	312	8	vigna	vigna	PROPN
dti-3495	312	9	unguiculata84	unguiculata84	PROPN
dti-3495	312	10	©	©	PROPN
dti-3495	312	11	2025	2025	NUM
dti-3495	312	12	the	the	DET
dti-3495	312	13	authors	author	NOUN
dti-3495	312	14	.	.	PUNCT
dti-3495	313	1	drug	drug	NOUN
dti-3495	313	2	target	target	NOUN
dti-3495	313	3	insights	insight	NOUN
dti-3495	313	4	issn	issn	VERB
dti-3495	313	5	1177	1177	NUM
dti-3495	313	6	-	-	SYM
dti-3495	313	7	3928	3928	NUM
dti-3495	313	8	www.aboutscience.eu/dti	www.aboutscience.eu/dti	NOUN
dti-3495	313	9	figure	figure	NOUN
dti-3495	313	10	10	10	NUM
dti-3495	313	11	the	the	DET
dti-3495	313	12	rmsd	rmsd	ADJ
dti-3495	313	13	parameter	parameter	NOUN
dti-3495	313	14	following	follow	VERB
dti-3495	313	15	the	the	DET
dti-3495	313	16	md	md	PROPN
dti-3495	313	17	simulation	simulation	NOUN
dti-3495	313	18	using	use	VERB
dti-3495	313	19	the	the	DET
dti-3495	313	20	compound	compound	NOUN
dti-3495	313	21	with	with	ADP
dti-3495	313	22	the	the	DET
dti-3495	313	23	highest	high	ADJ
dti-3495	313	24	binding	binding	ADJ
dti-3495	313	25	affinity	affinity	NOUN
dti-3495	313	26	.	.	PUNCT
dti-3495	314	1	the	the	DET
dti-3495	314	2	stigmasterol	stigmasterol	NOUN
dti-3495	314	3	showed	show	VERB
dti-3495	314	4	the	the	DET
dti-3495	314	5	highest	high	ADJ
dti-3495	314	6	binding	bind	VERB
dti-3495	314	7	affinity	affinity	NOUN
dti-3495	314	8	with	with	ADP
dti-3495	314	9	the	the	DET
dti-3495	314	10	8av1	8av1	NUM
dti-3495	314	11	,	,	PUNCT
dti-3495	314	12	luteolin	luteolin	PROPN
dti-3495	314	13	with	with	ADP
dti-3495	314	14	4ph9	4ph9	NUM
dti-3495	314	15	,	,	PUNCT
dti-3495	314	16	and	and	CCONJ
dti-3495	314	17	quercetin	quercetin	NOUN
dti-3495	314	18	with	with	ADP
dti-3495	314	19	the	the	DET
dti-3495	314	20	3fxi	3fxi	PROPN
dti-3495	314	21	.	.	PUNCT
dti-3495	315	1	the	the	DET
dti-3495	315	2	rmsd	rmsd	ADJ
dti-3495	315	3	analysis	analysis	NOUN
dti-3495	315	4	showed	show	VERB
dti-3495	315	5	that	that	SCONJ
dti-3495	315	6	all	all	DET
dti-3495	315	7	complexes	complex	NOUN
dti-3495	315	8	showed	show	VERB
dti-3495	315	9	an	an	DET
dti-3495	315	10	acceptable	acceptable	ADJ
dti-3495	315	11	value	value	NOUN
dti-3495	315	12	of	of	ADP
dti-3495	315	13	rmsd	rmsd	NOUN
dti-3495	315	14	,	,	PUNCT
dti-3495	315	15	and	and	CCONJ
dti-3495	315	16	no	no	DET
dti-3495	315	17	significant	significant	ADJ
dti-3495	315	18	changes	change	NOUN
dti-3495	315	19	were	be	AUX
dti-3495	315	20	observed	observe	VERB
dti-3495	315	21	.	.	PUNCT
dti-3495	316	1	figure	figure	VERB
dti-3495	316	2	11	11	NUM
dti-3495	316	3	the	the	DET
dti-3495	316	4	rmsf	rmsf	NOUN
dti-3495	316	5	analysis	analysis	NOUN
dti-3495	316	6	was	be	AUX
dti-3495	316	7	performed	perform	VERB
dti-3495	316	8	for	for	ADP
dti-3495	316	9	all	all	DET
dti-3495	316	10	the	the	DET
dti-3495	316	11	complexes	complex	NOUN
dti-3495	316	12	following	follow	VERB
dti-3495	316	13	the	the	DET
dti-3495	316	14	simulation	simulation	NOUN
dti-3495	316	15	.	.	PUNCT
dti-3495	317	1	the	the	DET
dti-3495	317	2	results	result	NOUN
dti-3495	317	3	showed	show	VERB
dti-3495	317	4	no	no	DET
dti-3495	317	5	major	major	ADJ
dti-3495	317	6	fluctuation	fluctuation	NOUN
dti-3495	317	7	in	in	ADP
dti-3495	317	8	the	the	DET
dti-3495	317	9	rmsf	rmsf	NOUN
dti-3495	317	10	value	value	NOUN
dti-3495	317	11	,	,	PUNCT
dti-3495	317	12	and	and	CCONJ
dti-3495	317	13	the	the	DET
dti-3495	317	14	results	result	NOUN
dti-3495	317	15	indicate	indicate	VERB
dti-3495	317	16	that	that	SCONJ
dti-3495	317	17	all	all	DET
dti-3495	317	18	complexes	complex	NOUN
dti-3495	317	19	remain	remain	VERB
dti-3495	317	20	stable	stable	ADJ
dti-3495	317	21	.	.	PUNCT
dti-3495	318	1	energy	energy	NOUN
dti-3495	318	2	,	,	PUNCT
dti-3495	318	3	as	as	SCONJ
dti-3495	318	4	shown	show	VERB
dti-3495	318	5	in	in	ADP
dti-3495	318	6	table	table	NOUN
dti-3495	318	7	5	5	NUM
dti-3495	318	8	and	and	CCONJ
dti-3495	318	9	supplementary	supplementary	ADJ
dti-3495	318	10	figure	figure	NOUN
dti-3495	318	11	3	3	NUM
dti-3495	318	12	.	.	PUNCT
dti-3495	318	13	similarly	similarly	ADV
dti-3495	318	14	,	,	PUNCT
dti-3495	318	15	the	the	DET
dti-3495	318	16	mm	mm	NOUN
dti-3495	318	17	-	-	PUNCT
dti-3495	318	18	pbsa	pbsa	NOUN
dti-3495	318	19	results	result	NOUN
dti-3495	318	20	were	be	AUX
dti-3495	318	21	validated	validate	VERB
dti-3495	318	22	using	use	VERB
dti-3495	318	23	the	the	DET
dti-3495	318	24	mm	mm	NOUN
dti-3495	318	25	-	-	PUNCT
dti-3495	318	26	gbsa	gbsa	ADJ
dti-3495	318	27	analysis	analysis	NOUN
dti-3495	318	28	.	.	PUNCT
dti-3495	319	1	during	during	ADP
dti-3495	319	2	the	the	DET
dti-3495	319	3	binding	binding	ADJ
dti-3495	319	4	free	free	ADJ
dti-3495	319	5	energy	energy	NOUN
dti-3495	319	6	calculations	calculation	NOUN
dti-3495	319	7	of	of	ADP
dti-3495	319	8	the	the	DET
dti-3495	319	9	4ph9	4ph9	NUM
dti-3495	319	10	_	_	NOUN
dti-3495	319	11	luteoline	luteoline	NOUN
dti-3495	319	12	using	use	VERB
dti-3495	319	13	mm	mm	PROPN
dti-3495	319	14	-	-	PUNCT
dti-3495	319	15	gbsa	gbsa	PROPN
dti-3495	319	16	revealed	reveal	VERB
dti-3495	319	17	that	that	SCONJ
dti-3495	319	18	the	the	DET
dti-3495	319	19	van	van	PROPN
dti-3495	319	20	der	der	NOUN
dti-3495	319	21	waals	waal	NOUN
dti-3495	319	22	energy	energy	NOUN
dti-3495	319	23	,	,	PUNCT
dti-3495	319	24	eel	eel	NOUN
dti-3495	319	25	,	,	PUNCT
dti-3495	319	26	esurf	esurf	NOUN
dti-3495	319	27	,	,	PUNCT
dti-3495	319	28	and	and	CCONJ
dti-3495	319	29	ggas	gga	NOUN
dti-3495	319	30	remain	remain	VERB
dti-3495	319	31	negative	negative	ADJ
dti-3495	319	32	and	and	CCONJ
dti-3495	319	33	exhibited	exhibit	VERB
dti-3495	319	34	favorable	favorable	ADJ
dti-3495	319	35	binding	binding	ADJ
dti-3495	319	36	energy	energy	NOUN
dti-3495	319	37	.	.	PUNCT
dti-3495	320	1	however	however	ADV
dti-3495	320	2	,	,	PUNCT
dti-3495	320	3	the	the	DET
dti-3495	320	4	egb	egb	NOUN
dti-3495	320	5	energy	energy	NOUN
dti-3495	320	6	and	and	CCONJ
dti-3495	320	7	gsolv	gsolv	ADJ
dti-3495	320	8	energy	energy	NOUN
dti-3495	320	9	of	of	ADP
dti-3495	320	10	the	the	DET
dti-3495	320	11	system	system	NOUN
dti-3495	320	12	remains	remain	VERB
dti-3495	320	13	positive	positive	ADJ
dti-3495	320	14	and	and	CCONJ
dti-3495	320	15	indicate	indicate	VERB
dti-3495	320	16	unfavorable	unfavorable	ADJ
dti-3495	320	17	binding	binding	ADJ
dti-3495	320	18	free	free	ADJ
dti-3495	320	19	energy	energy	NOUN
dti-3495	320	20	.	.	PUNCT
dti-3495	321	1	however	however	ADV
dti-3495	321	2	,	,	PUNCT
dti-3495	321	3	the	the	DET
dti-3495	321	4	total	total	ADJ
dti-3495	321	5	energy	energy	NOUN
dti-3495	321	6	of	of	ADP
dti-3495	321	7	the	the	DET
dti-3495	321	8	system	system	NOUN
dti-3495	321	9	is	be	AUX
dti-3495	321	10	negative	negative	ADJ
dti-3495	321	11	and	and	CCONJ
dti-3495	321	12	indicates	indicate	VERB
dti-3495	321	13	favorable	favorable	ADJ
dti-3495	321	14	binding	binding	ADJ
dti-3495	321	15	energy	energy	NOUN
dti-3495	321	16	,	,	PUNCT
dti-3495	321	17	as	as	SCONJ
dti-3495	321	18	shown	show	VERB
dti-3495	321	19	in	in	ADP
dti-3495	321	20	table	table	NOUN
dti-3495	321	21	6	6	NUM
dti-3495	321	22	and	and	CCONJ
dti-3495	321	23	supplementary	supplementary	ADJ
dti-3495	321	24	figure	figure	NOUN
dti-3495	321	25	4	4	NUM
dti-3495	321	26	.	.	PUNCT
dti-3495	322	1	the	the	DET
dti-3495	322	2	mm	mm	NOUN
dti-3495	322	3	-	-	PUNCT
dti-3495	322	4	pbsa	pbsa	NOUN
dti-3495	322	5	and	and	CCONJ
dti-3495	322	6	mm	mm	NOUN
dti-3495	322	7	-	-	PUNCT
dti-3495	322	8	gbsa	gbsa	ADJ
dti-3495	322	9	analyses	analysis	NOUN
dti-3495	322	10	were	be	AUX
dti-3495	322	11	performed	perform	VERB
dti-3495	322	12	for	for	ADP
dti-3495	322	13	all	all	DET
dti-3495	322	14	the	the	DET
dti-3495	322	15	complexes	complex	NOUN
dti-3495	322	16	to	to	PART
dti-3495	322	17	determine	determine	VERB
dti-3495	322	18	their	their	PRON
dti-3495	322	19	stability	stability	NOUN
dti-3495	322	20	in	in	ADP
dti-3495	322	21	terms	term	NOUN
dti-3495	322	22	of	of	ADP
dti-3495	322	23	binding	bind	VERB
dti-3495	322	24	energy	energy	NOUN
dti-3495	322	25	.	.	PUNCT
dti-3495	323	1	during	during	ADP
dti-3495	323	2	the	the	DET
dti-3495	323	3	binding	binding	ADJ
dti-3495	323	4	free	free	ADJ
dti-3495	323	5	energy	energy	NOUN
dti-3495	323	6	calculations	calculation	NOUN
dti-3495	323	7	of	of	ADP
dti-3495	323	8	the	the	DET
dti-3495	323	9	3fxi_quercetin	3fxi_quercetin	NOUN
dti-3495	323	10	using	use	VERB
dti-3495	323	11	mm	mm	NOUN
dti-3495	323	12	-	-	PUNCT
dti-3495	323	13	pbsa	pbsa	NOUN
dti-3495	323	14	revealed	reveal	VERB
dti-3495	323	15	that	that	SCONJ
dti-3495	323	16	the	the	DET
dti-3495	323	17	van	van	PROPN
dti-3495	323	18	der	der	NOUN
dti-3495	323	19	waals	waal	NOUN
dti-3495	323	20	energy	energy	NOUN
dti-3495	323	21	,	,	PUNCT
dti-3495	323	22	eel	eel	NOUN
dti-3495	323	23	,	,	PUNCT
dti-3495	323	24	enpolar	enpolar	ADJ
dti-3495	323	25	,	,	PUNCT
dti-3495	323	26	and	and	CCONJ
dti-3495	323	27	ggas	gga	NOUN
dti-3495	323	28	remain	remain	VERB
dti-3495	323	29	negative	negative	ADJ
dti-3495	323	30	and	and	CCONJ
dti-3495	323	31	exhibited	exhibit	VERB
dti-3495	323	32	favorable	favorable	ADJ
dti-3495	323	33	binding	binding	ADJ
dti-3495	323	34	energy	energy	NOUN
dti-3495	323	35	.	.	PUNCT
dti-3495	324	1	however	however	ADV
dti-3495	324	2	,	,	PUNCT
dti-3495	324	3	epb	epb	PROPN
dti-3495	324	4	energy	energy	NOUN
dti-3495	324	5	and	and	CCONJ
dti-3495	324	6	gsolv	gsolv	ADJ
dti-3495	324	7	energy	energy	NOUN
dti-3495	324	8	of	of	ADP
dti-3495	324	9	the	the	DET
dti-3495	324	10	system	system	NOUN
dti-3495	324	11	remains	remain	VERB
dti-3495	324	12	positive	positive	ADJ
dti-3495	324	13	and	and	CCONJ
dti-3495	324	14	indicate	indicate	VERB
dti-3495	324	15	unfavorable	unfavorable	ADJ
dti-3495	324	16	binding	binding	ADJ
dti-3495	324	17	free	free	ADJ
dti-3495	324	18	energy	energy	NOUN
dti-3495	324	19	.	.	PUNCT
dti-3495	325	1	however	however	ADV
dti-3495	325	2	,	,	PUNCT
dti-3495	325	3	the	the	DET
dti-3495	325	4	total	total	ADJ
dti-3495	325	5	energy	energy	NOUN
dti-3495	325	6	of	of	ADP
dti-3495	325	7	the	the	DET
dti-3495	325	8	system	system	NOUN
dti-3495	325	9	remains	remain	VERB
dti-3495	325	10	negative	negative	ADJ
dti-3495	325	11	and	and	CCONJ
dti-3495	325	12	indicates	indicate	VERB
dti-3495	325	13	favorable	favorable	ADJ
dti-3495	325	14	binding	binding	ADJ
dti-3495	325	15	energy	energy	NOUN
dti-3495	325	16	,	,	PUNCT
dti-3495	325	17	as	as	SCONJ
dti-3495	325	18	shown	show	VERB
dti-3495	325	19	in	in	ADP
dti-3495	325	20	table	table	NOUN
dti-3495	325	21	7	7	NUM
dti-3495	325	22	and	and	CCONJ
dti-3495	325	23	supplementary	supplementary	ADJ
dti-3495	325	24	figure	figure	NOUN
dti-3495	325	25	5	5	NUM
dti-3495	325	26	.	.	PUNCT
dti-3495	325	27	similarly	similarly	ADV
dti-3495	325	28	,	,	PUNCT
dti-3495	325	29	the	the	DET
dti-3495	325	30	mm	mm	NOUN
dti-3495	325	31	-	-	PUNCT
dti-3495	325	32	pbsa	pbsa	NOUN
dti-3495	325	33	results	result	NOUN
dti-3495	325	34	were	be	AUX
dti-3495	325	35	validated	validate	VERB
dti-3495	325	36	using	use	VERB
dti-3495	325	37	the	the	DET
dti-3495	325	38	mm	mm	NOUN
dti-3495	325	39	-	-	PUNCT
dti-3495	325	40	gbsa	gbsa	ADJ
dti-3495	325	41	analysis	analysis	NOUN
dti-3495	325	42	.	.	PUNCT
dti-3495	326	1	during	during	ADP
dti-3495	326	2	the	the	DET
dti-3495	326	3	binding	binding	ADJ
dti-3495	326	4	free	free	ADJ
dti-3495	326	5	energy	energy	NOUN
dti-3495	326	6	calculations	calculation	NOUN
dti-3495	326	7	of	of	ADP
dti-3495	326	8	the	the	DET
dti-3495	326	9	3fxi	3fxi	NOUN
dti-3495	326	10	_	_	NOUN
dti-3495	326	11	quercetin	quercetin	NOUN
dti-3495	326	12	using	use	VERB
dti-3495	326	13	mm	mm	PROPN
dti-3495	326	14	-	-	PUNCT
dti-3495	326	15	gbsa	gbsa	PROPN
dti-3495	326	16	revealed	reveal	VERB
dti-3495	326	17	that	that	SCONJ
dti-3495	326	18	the	the	DET
dti-3495	326	19	van	van	PROPN
dti-3495	326	20	der	der	NOUN
dti-3495	326	21	waals	waal	NOUN
dti-3495	326	22	energy	energy	NOUN
dti-3495	326	23	,	,	PUNCT
dti-3495	326	24	eel	eel	NOUN
dti-3495	326	25	,	,	PUNCT
dti-3495	326	26	esurf	esurf	NOUN
dti-3495	326	27	,	,	PUNCT
dti-3495	326	28	and	and	CCONJ
dti-3495	326	29	ggas	gga	NOUN
dti-3495	326	30	remain	remain	VERB
dti-3495	326	31	negative	negative	ADJ
dti-3495	326	32	and	and	CCONJ
dti-3495	326	33	exhibited	exhibit	VERB
dti-3495	326	34	favorable	favorable	ADJ
dti-3495	326	35	binding	binding	ADJ
dti-3495	326	36	energy	energy	NOUN
dti-3495	326	37	.	.	PUNCT
dti-3495	327	1	however	however	ADV
dti-3495	327	2	,	,	PUNCT
dti-3495	327	3	the	the	DET
dti-3495	327	4	egb	egb	NOUN
dti-3495	327	5	energy	energy	NOUN
dti-3495	327	6	and	and	CCONJ
dti-3495	327	7	gsolv	gsolv	ADJ
dti-3495	327	8	energy	energy	NOUN
dti-3495	327	9	of	of	ADP
dti-3495	327	10	the	the	DET
dti-3495	327	11	system	system	NOUN
dti-3495	327	12	remains	remain	VERB
dti-3495	327	13	positive	positive	ADJ
dti-3495	327	14	and	and	CCONJ
dti-3495	327	15	indicate	indicate	VERB
dti-3495	327	16	unfavorable	unfavorable	ADJ
dti-3495	327	17	binding	binding	ADJ
dti-3495	327	18	free	free	ADJ
dti-3495	327	19	energy	energy	NOUN
dti-3495	327	20	.	.	PUNCT
dti-3495	328	1	however	however	ADV
dti-3495	328	2	,	,	PUNCT
dti-3495	328	3	the	the	DET
dti-3495	328	4	total	total	ADJ
dti-3495	328	5	energy	energy	NOUN
dti-3495	328	6	of	of	ADP
dti-3495	328	7	the	the	DET
dti-3495	328	8	system	system	NOUN
dti-3495	328	9	is	be	AUX
dti-3495	328	10	negative	negative	ADJ
dti-3495	328	11	and	and	CCONJ
dti-3495	328	12	indicates	indicate	VERB
dti-3495	328	13	favorable	favorable	ADJ
dti-3495	328	14	binding	binding	ADJ
dti-3495	328	15	energy	energy	NOUN
dti-3495	328	16	,	,	PUNCT
dti-3495	328	17	sardar	sardar	PROPN
dti-3495	328	18	et	et	PROPN
dti-3495	328	19	al	al	PROPN
dti-3495	328	20	drug	drug	PROPN
dti-3495	328	21	target	target	NOUN
dti-3495	328	22	insights	insight	NOUN
dti-3495	328	23	2025	2025	NUM
dti-3495	328	24	;	;	PUNCT
dti-3495	328	25	19	19	NUM
dti-3495	328	26	:	:	SYM
dti-3495	328	27	85	85	NUM
dti-3495	328	28	©	©	PROPN
dti-3495	328	29	2025	2025	NUM
dti-3495	328	30	the	the	DET
dti-3495	328	31	authors	author	NOUN
dti-3495	328	32	.	.	PUNCT
dti-3495	329	1	published	publish	VERB
dti-3495	329	2	by	by	ADP
dti-3495	329	3	aboutscience	aboutscience	NOUN
dti-3495	329	4	www.aboutscience.eu	www.aboutscience.eu	NOUN
dti-3495	329	5	figure	figure	NOUN
dti-3495	329	6	12	12	NUM
dti-3495	329	7	the	the	DET
dti-3495	329	8	rog	rog	PROPN
dti-3495	329	9	of	of	ADP
dti-3495	329	10	all	all	DET
dti-3495	329	11	the	the	DET
dti-3495	329	12	complexes	complex	NOUN
dti-3495	329	13	was	be	AUX
dti-3495	329	14	determined	determine	VERB
dti-3495	329	15	following	follow	VERB
dti-3495	329	16	the	the	DET
dti-3495	329	17	simulation	simulation	NOUN
dti-3495	329	18	to	to	PART
dti-3495	329	19	assess	assess	VERB
dti-3495	329	20	the	the	DET
dti-3495	329	21	stability	stability	NOUN
dti-3495	329	22	of	of	ADP
dti-3495	329	23	the	the	DET
dti-3495	329	24	complexes	complex	NOUN
dti-3495	329	25	.	.	PUNCT
dti-3495	330	1	the	the	DET
dti-3495	330	2	rog	rog	PROPN
dti-3495	330	3	results	result	NOUN
dti-3495	330	4	showed	show	VERB
dti-3495	330	5	that	that	SCONJ
dti-3495	330	6	8av1_stigmasterol	8av1_stigmasterol	NOUN
dti-3495	330	7	,	,	PUNCT
dti-3495	330	8	and	and	CCONJ
dti-3495	330	9	4ph9_luteolin	4ph9_luteolin	NOUN
dti-3495	330	10	complexes	complex	NOUN
dti-3495	330	11	are	be	AUX
dti-3495	330	12	lowered	lower	VERB
dti-3495	330	13	as	as	ADP
dti-3495	330	14	compared	compare	VERB
dti-3495	330	15	to	to	ADP
dti-3495	330	16	the	the	DET
dti-3495	330	17	3fxi_quercetin	3fxi_quercetin	NUM
dti-3495	330	18	complex	complex	NOUN
dti-3495	330	19	.	.	PUNCT
dti-3495	331	1	figure	figure	NOUN
dti-3495	331	2	14	14	NUM
dti-3495	331	3	the	the	DET
dti-3495	331	4	3fxi_quercetin	3fxi_quercetin	NUM
dti-3495	331	5	showed	show	VERB
dti-3495	331	6	the	the	DET
dti-3495	331	7	highest	high	ADJ
dti-3495	331	8	number	number	NOUN
dti-3495	331	9	of	of	ADP
dti-3495	331	10	hydrogen	hydrogen	NOUN
dti-3495	331	11	,	,	PUNCT
dti-3495	331	12	i.e.	i.e.	X
dti-3495	331	13	,	,	PUNCT
dti-3495	331	14	five	five	NUM
dti-3495	331	15	,	,	PUNCT
dti-3495	331	16	as	as	SCONJ
dti-3495	331	17	compared	compare	VERB
dti-3495	331	18	to	to	ADP
dti-3495	331	19	the	the	DET
dti-3495	331	20	8av1_stigmasterol	8av1_stigmasterol	PROPN
dti-3495	331	21	and	and	CCONJ
dti-3495	331	22	4ph9_luteolin	4ph9_luteolin	PROPN
dti-3495	331	23	complex	complex	NOUN
dti-3495	331	24	.	.	PUNCT
dti-3495	332	1	figure	figure	NOUN
dti-3495	332	2	13	13	NUM
dti-3495	332	3	the	the	DET
dti-3495	332	4	8av1_stigamsterol	8av1_stigamsterol	PROPN
dti-3495	332	5	result	result	NOUN
dti-3495	332	6	revealed	reveal	VERB
dti-3495	332	7	the	the	DET
dti-3495	332	8	lowest	low	ADJ
dti-3495	332	9	sasa	sasa	NOUN
dti-3495	332	10	as	as	SCONJ
dti-3495	332	11	compared	compare	VERB
dti-3495	332	12	to	to	ADP
dti-3495	332	13	the	the	DET
dti-3495	332	14	4ph9_luteolin	4ph9_luteolin	PROPN
dti-3495	332	15	and	and	CCONJ
dti-3495	332	16	3fxi	3fxi	NOUN
dti-3495	332	17	_	_	NOUN
dti-3495	332	18	quercetin	quercetin	NOUN
dti-3495	332	19	complexes	complex	NOUN
dti-3495	332	20	.	.	PUNCT
dti-3495	333	1	in	in	ADP
dti-3495	333	2	silico	silico	NOUN
dti-3495	333	3	anti	anti	ADJ
dti-3495	333	4	-	-	ADJ
dti-3495	333	5	diabetic	diabetic	ADJ
dti-3495	333	6	potential	potential	NOUN
dti-3495	333	7	of	of	ADP
dti-3495	333	8	vigna	vigna	PROPN
dti-3495	333	9	unguiculata86	unguiculata86	PROPN
dti-3495	334	1	©	©	PROPN
dti-3495	334	2	2025	2025	NUM
dti-3495	334	3	the	the	DET
dti-3495	334	4	authors	author	NOUN
dti-3495	334	5	.	.	PUNCT
dti-3495	335	1	drug	drug	NOUN
dti-3495	335	2	target	target	NOUN
dti-3495	335	3	insights	insight	NOUN
dti-3495	335	4	issn	issn	VERB
dti-3495	335	5	1177	1177	NUM
dti-3495	335	6	-	-	SYM
dti-3495	335	7	3928	3928	NUM
dti-3495	335	8	www.aboutscience.eu/dti	www.aboutscience.eu/dti	NOUN
dti-3495	335	9	as	as	SCONJ
dti-3495	335	10	shown	show	VERB
dti-3495	335	11	in	in	ADP
dti-3495	335	12	table	table	NOUN
dti-3495	335	13	8	8	NUM
dti-3495	335	14	and	and	CCONJ
dti-3495	335	15	supplementary	supplementary	ADJ
dti-3495	335	16	figure	figure	NOUN
dti-3495	335	17	6	6	NUM
dti-3495	335	18	.	.	PUNCT
dti-3495	336	1	the	the	DET
dti-3495	336	2	binding	bind	VERB
dti-3495	336	3	free	free	ADJ
dti-3495	336	4	energy	energy	NOUN
dti-3495	336	5	calculations	calculation	NOUN
dti-3495	336	6	revealed	reveal	VERB
dti-3495	336	7	that	that	SCONJ
dti-3495	336	8	8av1_stigmaterol	8av1_stigmaterol	PROPN
dti-3495	336	9	showed	show	VERB
dti-3495	336	10	the	the	DET
dti-3495	336	11	highest	high	ADJ
dti-3495	336	12	total	total	ADJ
dti-3495	336	13	binding	bind	VERB
dti-3495	336	14	free	free	ADJ
dti-3495	336	15	energies	energy	NOUN
dti-3495	336	16	(	(	PUNCT
dti-3495	336	17	mm	mm	NOUN
dti-3495	336	18	-	-	PUNCT
dti-3495	336	19	pbsa	pbsa	NOUN
dti-3495	336	20	=	=	SYM
dti-3495	336	21	-23.51	-23.51	PROPN
dti-3495	336	22	,	,	PUNCT
dti-3495	336	23	mm	mm	PROPN
dti-3495	336	24	-	-	PUNCT
dti-3495	336	25	gbsa	gbsa	ADJ
dti-3495	336	26	=	=	PUNCT
dti-3495	336	27	−31.52	−31.52	X
dti-3495	336	28	)	)	PUNCT
dti-3495	336	29	,	,	PUNCT
dti-3495	336	30	followed	follow	VERB
dti-3495	336	31	by	by	ADP
dti-3495	336	32	the	the	DET
dti-3495	336	33	3fxi_quercetin	3fxi_quercetin	NUM
dti-3495	336	34	(	(	PUNCT
dti-3495	336	35	mm	mm	NOUN
dti-3495	336	36	-	-	PUNCT
dti-3495	336	37	pbsa	pbsa	NOUN
dti-3495	336	38	=	=	SYM
dti-3495	336	39	−22.27	−22.27	PROPN
dti-3495	336	40	,	,	PUNCT
dti-3495	336	41	mm	mm	PROPN
dti-3495	336	42	-	-	PUNCT
dti-3495	336	43	gbsa	gbsa	ADJ
dti-3495	336	44	=	=	PUNCT
dti-3495	336	45	−30.56	−30.56	NOUN
dti-3495	336	46	)	)	PUNCT
dti-3495	336	47	,	,	PUNCT
dti-3495	336	48	and	and	CCONJ
dti-3495	336	49	the	the	DET
dti-3495	336	50	lowest	low	ADJ
dti-3495	336	51	binding	binding	ADJ
dti-3495	336	52	free	free	ADJ
dti-3495	336	53	energies	energy	NOUN
dti-3495	336	54	were	be	AUX
dti-3495	336	55	shown	show	VERB
dti-3495	336	56	by	by	ADP
dti-3495	336	57	the	the	DET
dti-3495	336	58	4ph9_luteoline	4ph9_luteoline	PROPN
dti-3495	336	59	(	(	PUNCT
dti-3495	336	60	mm	mm	NOUN
dti-3495	336	61	-	-	PUNCT
dti-3495	336	62	pbsa	pbsa	NOUN
dti-3495	336	63	=	=	SYM
dti-3495	336	64	−10.38	−10.38	PROPN
dti-3495	336	65	,	,	PUNCT
dti-3495	336	66	mm	mm	PROPN
dti-3495	336	67	-	-	PUNCT
dti-3495	336	68	gbsa	gbsa	ADJ
dti-3495	336	69	=	=	PUNCT
dti-3495	336	70	−19.91	−19.91	NOUN
dti-3495	336	71	)	)	PUNCT
dti-3495	336	72	.	.	PUNCT
dti-3495	337	1	the	the	DET
dti-3495	337	2	contribution	contribution	NOUN
dti-3495	337	3	of	of	ADP
dti-3495	337	4	the	the	DET
dti-3495	337	5	individual	individual	ADJ
dti-3495	337	6	residues	residue	NOUN
dti-3495	337	7	was	be	AUX
dti-3495	337	8	determined	determine	VERB
dti-3495	337	9	using	use	VERB
dti-3495	337	10	per	per	ADP
dti-3495	337	11	-	-	PUNCT
dti-3495	337	12	residue	residue	NOUN
dti-3495	337	13	decomposition	decomposition	NOUN
dti-3495	337	14	analysis	analysis	NOUN
dti-3495	337	15	for	for	ADP
dti-3495	337	16	all	all	DET
dti-3495	337	17	the	the	DET
dti-3495	337	18	complexes	complex	NOUN
dti-3495	337	19	.	.	PUNCT
dti-3495	338	1	the	the	DET
dti-3495	338	2	per	per	ADP
dti-3495	338	3	-	-	PUNCT
dti-3495	338	4	residue	residue	NOUN
dti-3495	338	5	decomposition	decomposition	NOUN
dti-3495	338	6	analysis	analysis	NOUN
dti-3495	338	7	showed	show	VERB
dti-3495	338	8	that	that	SCONJ
dti-3495	338	9	val45	val45	PROPN
dti-3495	338	10	and	and	CCONJ
dti-3495	338	11	ile37	ile37	NOUN
dti-3495	338	12	were	be	AUX
dti-3495	338	13	the	the	DET
dti-3495	338	14	highest	high	ADJ
dti-3495	338	15	energy	energy	NOUN
dti-3495	338	16	contributing	contribute	VERB
dti-3495	338	17	amino	amino	ADJ
dti-3495	338	18	acids	acid	NOUN
dti-3495	338	19	in	in	ADP
dti-3495	338	20	the	the	DET
dti-3495	338	21	8av1_stigmasterol	8av1_stigmasterol	PROPN
dti-3495	338	22	complex	complex	NOUN
dti-3495	338	23	using	use	VERB
dti-3495	338	24	mm	mm	NOUN
dti-3495	338	25	-	-	PUNCT
dti-3495	338	26	pbsa	pbsa	NOUN
dti-3495	338	27	and	and	CCONJ
dti-3495	338	28	mm	mm	NOUN
dti-3495	338	29	-	-	PUNCT
dti-3495	338	30	gbsa	gbsa	PROPN
dti-3495	338	31	,	,	PUNCT
dti-3495	338	32	respectively	respectively	ADV
dti-3495	338	33	,	,	PUNCT
dti-3495	338	34	supplementary	supplementary	ADJ
dti-3495	338	35	figure	figure	NOUN
dti-3495	338	36	7	7	NUM
dti-3495	338	37	.	.	PUNCT
dti-3495	339	1	meanwhile	meanwhile	ADV
dti-3495	339	2	,	,	PUNCT
dti-3495	339	3	in	in	ADP
dti-3495	339	4	4ph9_luteoline	4ph9_luteoline	ADJ
dti-3495	339	5	complex	complex	ADJ
dti-3495	339	6	decomposition	decomposition	NOUN
dti-3495	339	7	analysis	analysis	NOUN
dti-3495	339	8	,	,	PUNCT
dti-3495	339	9	it	it	PRON
dti-3495	339	10	was	be	AUX
dti-3495	339	11	revealed	reveal	VERB
dti-3495	339	12	that	that	SCONJ
dti-3495	339	13	cys36	cys36	NOUN
dti-3495	339	14	and	and	CCONJ
dti-3495	339	15	pro154	pro154	PROPN
dti-3495	339	16	were	be	AUX
dti-3495	339	17	the	the	DET
dti-3495	339	18	highest	high	ADJ
dti-3495	339	19	contributing	contribute	VERB
dti-3495	339	20	amino	amino	ADJ
dti-3495	339	21	acids	acid	NOUN
dti-3495	339	22	using	use	VERB
dti-3495	339	23	mm	mm	NOUN
dti-3495	339	24	-	-	PUNCT
dti-3495	339	25	pbsa	pbsa	NOUN
dti-3495	339	26	and	and	CCONJ
dti-3495	339	27	mm	mm	NOUN
dti-3495	339	28	-	-	PUNCT
dti-3495	339	29	gbsa	gbsa	ADJ
dti-3495	339	30	parameters	parameter	NOUN
dti-3495	339	31	,	,	PUNCT
dti-3495	339	32	respectively	respectively	ADV
dti-3495	339	33	,	,	PUNCT
dti-3495	339	34	supplementary	supplementary	ADJ
dti-3495	339	35	figure	figure	NOUN
dti-3495	339	36	8	8	NUM
dti-3495	339	37	.	.	PUNCT
dti-3495	340	1	the	the	DET
dti-3495	340	2	per	per	ADP
dti-3495	340	3	-	-	PUNCT
dti-3495	340	4	residue	residue	NOUN
dti-3495	340	5	decomposition	decomposition	NOUN
dti-3495	340	6	analysis	analysis	NOUN
dti-3495	340	7	of	of	ADP
dti-3495	340	8	the	the	DET
dti-3495	340	9	3fxi	3fxi	PROPN
dti-3495	340	10	_	_	NOUN
dti-3495	340	11	quercetin	quercetin	NOUN
dti-3495	340	12	showed	show	VERB
dti-3495	340	13	that	that	SCONJ
dti-3495	340	14	glu128	glu128	PROPN
dti-3495	340	15	was	be	AUX
dti-3495	340	16	the	the	DET
dti-3495	340	17	highest	high	ADJ
dti-3495	340	18	contributing	contribute	VERB
dti-3495	340	19	residue	residue	NOUN
dti-3495	340	20	using	use	VERB
dti-3495	340	21	mm	mm	NOUN
dti-3495	340	22	-	-	PUNCT
dti-3495	340	23	pbsa	pbsa	NOUN
dti-3495	340	24	and	and	CCONJ
dti-3495	340	25	mm	mm	NOUN
dti-3495	340	26	-	-	PUNCT
dti-3495	340	27	gbsa	gbsa	ADJ
dti-3495	340	28	analysis	analysis	NOUN
dti-3495	340	29	,	,	PUNCT
dti-3495	340	30	as	as	SCONJ
dti-3495	340	31	shown	show	VERB
dti-3495	340	32	in	in	ADP
dti-3495	340	33	the	the	DET
dti-3495	340	34	supplementary	supplementary	ADJ
dti-3495	340	35	figure	figure	NOUN
dti-3495	340	36	9	9	NUM
dti-3495	340	37	.	.	PUNCT
dti-3495	341	1	discussion	discussion	NOUN
dti-3495	341	2	the	the	DET
dti-3495	341	3	use	use	NOUN
dti-3495	341	4	of	of	ADP
dti-3495	341	5	natural	natural	ADJ
dti-3495	341	6	remedies	remedy	NOUN
dti-3495	341	7	as	as	ADP
dti-3495	341	8	additional	additional	ADJ
dti-3495	341	9	treatments	treatment	NOUN
dti-3495	341	10	alongside	alongside	ADP
dti-3495	341	11	conventional	conventional	ADJ
dti-3495	341	12	therapies	therapy	NOUN
dti-3495	341	13	for	for	ADP
dti-3495	341	14	the	the	DET
dti-3495	341	15	treatment	treatment	NOUN
dti-3495	341	16	of	of	ADP
dti-3495	341	17	table	table	NOUN
dti-3495	341	18	3	3	NUM
dti-3495	341	19	the	the	DET
dti-3495	341	20	mm	mm	NOUN
dti-3495	341	21	-	-	PUNCT
dti-3495	341	22	pbsa	pbsa	NOUN
dti-3495	341	23	result	result	NOUN
dti-3495	341	24	of	of	ADP
dti-3495	341	25	the	the	DET
dti-3495	341	26	8av1_stigamsterol	8av1_stigamsterol	PROPN
dti-3495	341	27	complex	complex	NOUN
dti-3495	341	28	frames	frame	NOUN
dti-3495	341	29	vdwaals	vdwaal	NOUN
dti-3495	341	30	eel	eel	X
dti-3495	341	31	epb	epb	PROPN
dti-3495	341	32	enpolar	enpolar	PROPN
dti-3495	341	33	ggas	ggas	PROPN
dti-3495	341	34	gsolv	gsolv	PROPN
dti-3495	341	35	total	total	PROPN
dti-3495	341	36	average	average	ADJ
dti-3495	341	37	−39.97	−39.97	NOUN
dti-3495	341	38	−8.1	−8.1	PROPN
dti-3495	341	39	29.08	29.08	NUM
dti-3495	341	40	−4.52	−4.52	NOUN
dti-3495	341	41	−48.07	−48.07	ADP
dti-3495	341	42	24.56	24.56	NUM
dti-3495	341	43	−23.51	−23.51	NOUN
dti-3495	341	44	sd	sd	ADP
dti-3495	341	45	3.34	3.34	NUM
dti-3495	341	46	5.49	5.49	NUM
dti-3495	341	47	4.09	4.09	NUM
dti-3495	341	48	0.21	0.21	NUM
dti-3495	341	49	6.2	6.2	NUM
dti-3495	341	50	4.03	4.03	NUM
dti-3495	341	51	4.8	4.8	NUM
dti-3495	341	52	sem	sem	NOUN
dti-3495	341	53	0.15	0.15	NUM
dti-3495	341	54	0.25	0.25	NUM
dti-3495	341	55	0.18	0.18	NUM
dti-3495	341	56	0.01	0.01	NUM
dti-3495	341	57	0.28	0.28	NUM
dti-3495	341	58	0.18	0.18	NUM
dti-3495	341	59	0.21	0.21	NUM
dti-3495	341	60	table	table	NOUN
dti-3495	341	61	4	4	NUM
dti-3495	341	62	the	the	DET
dti-3495	341	63	mm	mm	ADJ
dti-3495	341	64	-	-	PUNCT
dti-3495	341	65	gbsa	gbsa	ADJ
dti-3495	341	66	result	result	NOUN
dti-3495	341	67	of	of	ADP
dti-3495	341	68	the	the	DET
dti-3495	341	69	8av1_stigamsterol	8av1_stigamsterol	PROPN
dti-3495	341	70	complex	complex	NOUN
dti-3495	341	71	frames	frame	NOUN
dti-3495	341	72	vdwaals	vdwaal	NOUN
dti-3495	341	73	eel	eel	VERB
dti-3495	341	74	egb	egb	PROPN
dti-3495	341	75	esurf	esurf	PROPN
dti-3495	341	76	ggas	ggas	PROPN
dti-3495	341	77	gsolv	gsolv	PROPN
dti-3495	341	78	total	total	PROPN
dti-3495	341	79	average	average	ADJ
dti-3495	341	80	−39.97	−39.97	NOUN
dti-3495	341	81	−8.1	−8.1	PROPN
dti-3495	341	82	21.8	21.8	NUM
dti-3495	341	83	−5.26	−5.26	NOUN
dti-3495	341	84	−48.07	−48.07	ADP
dti-3495	341	85	16.54	16.54	NUM
dti-3495	341	86	−31.52	−31.52	PROPN
dti-3495	341	87	sd	sd	ADP
dti-3495	341	88	3.34	3.34	NUM
dti-3495	341	89	5.49	5.49	NUM
dti-3495	341	90	3.5	3.5	NUM
dti-3495	341	91	0.45	0.45	NUM
dti-3495	341	92	6.2	6.2	NUM
dti-3495	341	93	3.36	3.36	NUM
dti-3495	341	94	4.2	4.2	NUM
dti-3495	341	95	sem	sem	NOUN
dti-3495	341	96	0.15	0.15	NUM
dti-3495	341	97	0.25	0.25	NUM
dti-3495	341	98	0.16	0.16	NUM
dti-3495	341	99	0.02	0.02	NUM
dti-3495	341	100	0.28	0.28	NUM
dti-3495	341	101	0.15	0.15	NUM
dti-3495	341	102	0.19	0.19	NUM
dti-3495	341	103	table	table	NOUN
dti-3495	341	104	5	5	NUM
dti-3495	341	105	the	the	DET
dti-3495	341	106	mm	mm	NOUN
dti-3495	341	107	-	-	PUNCT
dti-3495	341	108	pbsa	pbsa	NOUN
dti-3495	341	109	result	result	NOUN
dti-3495	341	110	of	of	ADP
dti-3495	341	111	the	the	DET
dti-3495	341	112	4ph9_luteolin	4ph9_luteolin	PROPN
dti-3495	341	113	complex	complex	NOUN
dti-3495	341	114	frames	frame	NOUN
dti-3495	341	115	vdwaals	vdwaal	NOUN
dti-3495	341	116	eel	eel	X
dti-3495	341	117	epb	epb	PROPN
dti-3495	341	118	enpolar	enpolar	PROPN
dti-3495	341	119	ggas	ggas	PROPN
dti-3495	341	120	gsolv	gsolv	PROPN
dti-3495	341	121	total	total	ADJ
dti-3495	341	122	average	average	ADJ
dti-3495	341	123	−30.05	−30.05	NOUN
dti-3495	341	124	−20.24	−20.24	NOUN
dti-3495	341	125	43.36	43.36	NUM
dti-3495	341	126	−3.45	−3.45	X
dti-3495	341	127	−50.29	−50.29	NOUN
dti-3495	341	128	39.91	39.91	NUM
dti-3495	341	129	−10.38	−10.38	NOUN
dti-3495	341	130	sd	sd	ADP
dti-3495	341	131	2.24	2.24	NUM
dti-3495	341	132	3.66	3.66	NUM
dti-3495	341	133	4.34	4.34	NUM
dti-3495	341	134	0.07	0.07	NUM
dti-3495	341	135	3.99	3.99	NUM
dti-3495	341	136	4.32	4.32	NUM
dti-3495	341	137	2.78	2.78	NUM
dti-3495	341	138	sem	sem	NOUN
dti-3495	341	139	0.1	0.1	NUM
dti-3495	341	140	0.16	0.16	NUM
dti-3495	341	141	0.19	0.19	NUM
dti-3495	341	142	0	0	NUM
dti-3495	341	143	0.18	0.18	NUM
dti-3495	341	144	0.19	0.19	NUM
dti-3495	341	145	0.12	0.12	NUM
dti-3495	341	146	table	table	NOUN
dti-3495	341	147	6	6	NUM
dti-3495	341	148	the	the	DET
dti-3495	341	149	mm	mm	PROPN
dti-3495	341	150	-	-	PUNCT
dti-3495	341	151	gbsa	gbsa	ADJ
dti-3495	341	152	result	result	NOUN
dti-3495	341	153	of	of	ADP
dti-3495	341	154	the	the	DET
dti-3495	341	155	4ph9_luteolin	4ph9_luteolin	PROPN
dti-3495	341	156	complex	complex	NOUN
dti-3495	341	157	frames	frame	NOUN
dti-3495	341	158	vdwaals	vdwaal	NOUN
dti-3495	341	159	eel	eel	VERB
dti-3495	341	160	egb	egb	PROPN
dti-3495	341	161	esurf	esurf	PROPN
dti-3495	341	162	ggas	ggas	PROPN
dti-3495	341	163	gsolv	gsolv	PROPN
dti-3495	341	164	total	total	ADJ
dti-3495	341	165	average	average	ADJ
dti-3495	341	166	−30.05	−30.05	NOUN
dti-3495	341	167	−20.24	−20.24	NOUN
dti-3495	341	168	35.12	35.12	NUM
dti-3495	341	169	−4.74	−4.74	ADP
dti-3495	341	170	-50.29	-50.29	PROPN
dti-3495	341	171	30.38	30.38	NUM
dti-3495	341	172	−19.91	−19.91	INTJ
dti-3495	341	173	sd	sd	ADP
dti-3495	341	174	2.24	2.24	NUM
dti-3495	341	175	3.66	3.66	NUM
dti-3495	341	176	3.43	3.43	NUM
dti-3495	341	177	0.17	0.17	NUM
dti-3495	341	178	3.99	3.99	NUM
dti-3495	341	179	3.34	3.34	NUM
dti-3495	341	180	2.03	2.03	NUM
dti-3495	341	181	sem	sem	NOUN
dti-3495	341	182	0.1	0.1	NUM
dti-3495	341	183	0.16	0.16	NUM
dti-3495	341	184	0.15	0.15	NUM
dti-3495	341	185	0.01	0.01	NUM
dti-3495	341	186	0.18	0.18	NUM
dti-3495	341	187	0.15	0.15	NUM
dti-3495	341	188	0.09	0.09	NUM
dti-3495	341	189	table	table	NOUN
dti-3495	341	190	7	7	NUM
dti-3495	341	191	the	the	DET
dti-3495	341	192	mm	mm	NOUN
dti-3495	341	193	-	-	PUNCT
dti-3495	341	194	pbsa	pbsa	NOUN
dti-3495	341	195	result	result	NOUN
dti-3495	341	196	of	of	ADP
dti-3495	341	197	the	the	DET
dti-3495	341	198	3fxi_quercetin	3fxi_quercetin	NUM
dti-3495	341	199	complex	complex	ADJ
dti-3495	341	200	frames	frame	NOUN
dti-3495	341	201	vdwaals	vdwaal	NOUN
dti-3495	341	202	eel	eel	X
dti-3495	341	203	epb	epb	PROPN
dti-3495	341	204	enpolar	enpolar	PROPN
dti-3495	341	205	ggas	ggas	PROPN
dti-3495	341	206	gsolv	gsolv	PROPN
dti-3495	341	207	total	total	PROPN
dti-3495	341	208	average	average	ADJ
dti-3495	341	209	−21.08	−21.08	PROPN
dti-3495	341	210	−46.49	−46.49	ADP
dti-3495	341	211	48.11	48.11	NUM
dti-3495	341	212	−2.8	−2.8	NOUN
dti-3495	341	213	−67.58	−67.58	VERB
dti-3495	341	214	45.31	45.31	NUM
dti-3495	341	215	−22.27	−22.27	X
dti-3495	341	216	sd	sd	ADP
dti-3495	341	217	2.85	2.85	NUM
dti-3495	341	218	5.84	5.84	NUM
dti-3495	341	219	4.45	4.45	NUM
dti-3495	341	220	0.06	0.06	NUM
dti-3495	341	221	4.95	4.95	NUM
dti-3495	341	222	4.45	4.45	NUM
dti-3495	341	223	2.8	2.8	NUM
dti-3495	341	224	sem	sem	NOUN
dti-3495	341	225	0.13	0.13	NUM
dti-3495	341	226	0.26	0.26	NUM
dti-3495	341	227	0.2	0.2	NUM
dti-3495	341	228	0	0	NUM
dti-3495	341	229	0.22	0.22	NUM
dti-3495	341	230	0.2	0.2	NUM
dti-3495	341	231	0.13	0.13	NUM
dti-3495	341	232	sardar	sardar	PROPN
dti-3495	341	233	et	et	PROPN
dti-3495	341	234	al	al	PROPN
dti-3495	341	235	drug	drug	PROPN
dti-3495	341	236	target	target	NOUN
dti-3495	341	237	insights	insight	NOUN
dti-3495	341	238	2025	2025	NUM
dti-3495	341	239	;	;	PUNCT
dti-3495	341	240	19	19	NUM
dti-3495	341	241	:	:	SYM
dti-3495	341	242	87	87	NUM
dti-3495	341	243	©	©	ADP
dti-3495	341	244	2025	2025	NUM
dti-3495	341	245	the	the	DET
dti-3495	341	246	authors	author	NOUN
dti-3495	341	247	.	.	PUNCT
dti-3495	342	1	published	publish	VERB
dti-3495	342	2	by	by	ADP
dti-3495	342	3	aboutscience	aboutscience	NOUN
dti-3495	342	4	www.aboutscience.eu	www.aboutscience.eu	NOUN
dti-3495	342	5	diabetes	diabetes	NOUN
dti-3495	342	6	and	and	CCONJ
dti-3495	342	7	its	its	PRON
dti-3495	342	8	associated	associated	ADJ
dti-3495	342	9	complications	complication	NOUN
dti-3495	342	10	is	be	AUX
dti-3495	342	11	increasing	increase	VERB
dti-3495	342	12	worldwide	worldwide	ADV
dti-3495	342	13	,	,	PUNCT
dti-3495	342	14	with	with	ADP
dti-3495	342	15	many	many	ADJ
dti-3495	342	16	plants	plant	NOUN
dti-3495	342	17	in	in	ADP
dti-3495	342	18	different	different	ADJ
dti-3495	342	19	countries	country	NOUN
dti-3495	342	20	known	know	VERB
dti-3495	342	21	to	to	PART
dti-3495	342	22	have	have	VERB
dti-3495	342	23	effects	effect	NOUN
dti-3495	342	24	in	in	ADP
dti-3495	342	25	lowering	lower	VERB
dti-3495	342	26	blood	blood	NOUN
dti-3495	342	27	sugar	sugar	NOUN
dti-3495	342	28	(	(	PUNCT
dti-3495	342	29	41	41	NUM
dti-3495	342	30	)	)	PUNCT
dti-3495	342	31	.	.	PUNCT
dti-3495	343	1	indian	indian	PROPN
dti-3495	343	2	literature	literature	PROPN
dti-3495	343	3	from	from	ADP
dti-3495	343	4	the	the	DET
dti-3495	343	5	past	past	NOUN
dti-3495	343	6	has	have	AUX
dti-3495	343	7	documented	document	VERB
dti-3495	343	8	the	the	DET
dti-3495	343	9	anti	anti	ADJ
dti-3495	343	10	-	-	ADJ
dti-3495	343	11	diabetic	diabetic	ADJ
dti-3495	343	12	properties	property	NOUN
dti-3495	343	13	of	of	ADP
dti-3495	343	14	more	more	ADJ
dti-3495	343	15	than	than	ADP
dti-3495	343	16	800	800	NUM
dti-3495	343	17	plants	plant	NOUN
dti-3495	343	18	,	,	PUNCT
dti-3495	343	19	while	while	SCONJ
dti-3495	343	20	ethnopharmacological	ethnopharmacological	ADJ
dti-3495	343	21	research	research	NOUN
dti-3495	343	22	has	have	AUX
dti-3495	343	23	shown	show	VERB
dti-3495	343	24	that	that	SCONJ
dti-3495	343	25	over	over	ADP
dti-3495	343	26	1200	1200	NUM
dti-3495	343	27	plants	plant	NOUN
dti-3495	343	28	can	can	AUX
dti-3495	343	29	be	be	AUX
dti-3495	343	30	used	use	VERB
dti-3495	343	31	for	for	ADP
dti-3495	343	32	their	their	PRON
dti-3495	343	33	antidiabetic	antidiabetic	ADJ
dti-3495	343	34	effects	effect	NOUN
dti-3495	343	35	(	(	PUNCT
dti-3495	343	36	42	42	NUM
dti-3495	343	37	)	)	PUNCT
dti-3495	343	38	.	.	PUNCT
dti-3495	344	1	the	the	DET
dti-3495	344	2	primary	primary	ADJ
dti-3495	344	3	reason	reason	NOUN
dti-3495	344	4	for	for	ADP
dti-3495	344	5	postprandial	postprandial	ADJ
dti-3495	344	6	hyperglycemia	hyperglycemia	NOUN
dti-3495	344	7	is	be	AUX
dti-3495	344	8	the	the	DET
dti-3495	344	9	action	action	NOUN
dti-3495	344	10	of	of	ADP
dti-3495	344	11	α	α	NOUN
dti-3495	344	12	-	-	NOUN
dti-3495	344	13	amylase	amylase	NOUN
dti-3495	344	14	and	and	CCONJ
dti-3495	344	15	α	α	NOUN
dti-3495	344	16	-	-	PUNCT
dti-3495	344	17	glucosidase	glucosidase	ADJ
dti-3495	344	18	enzymes	enzyme	NOUN
dti-3495	344	19	,	,	PUNCT
dti-3495	344	20	which	which	PRON
dti-3495	344	21	break	break	VERB
dti-3495	344	22	down	down	ADP
dti-3495	344	23	carbohydrates	carbohydrate	NOUN
dti-3495	344	24	.	.	PUNCT
dti-3495	345	1	the	the	DET
dti-3495	345	2	process	process	NOUN
dti-3495	345	3	of	of	ADP
dti-3495	345	4	breaking	break	VERB
dti-3495	345	5	down	down	ADP
dti-3495	345	6	carbohydrates	carbohydrate	NOUN
dti-3495	345	7	starts	start	VERB
dti-3495	345	8	with	with	ADP
dti-3495	345	9	α	α	NOUN
dti-3495	345	10	-	-	NOUN
dti-3495	345	11	amylase	amylase	NOUN
dti-3495	345	12	,	,	PUNCT
dti-3495	345	13	which	which	PRON
dti-3495	345	14	breaks	break	VERB
dti-3495	345	15	the	the	DET
dti-3495	345	16	1,4	1,4	ADJ
dti-3495	345	17	-	-	ADJ
dti-3495	345	18	glycosidic	glycosidic	ADJ
dti-3495	345	19	bonds	bond	NOUN
dti-3495	345	20	in	in	ADP
dti-3495	345	21	polysaccharides	polysaccharide	NOUN
dti-3495	345	22	,	,	PUNCT
dti-3495	345	23	converting	convert	VERB
dti-3495	345	24	them	they	PRON
dti-3495	345	25	into	into	ADP
dti-3495	345	26	disaccharides	disaccharide	NOUN
dti-3495	345	27	.	.	PUNCT
dti-3495	346	1	subsequently	subsequently	ADV
dti-3495	346	2	,	,	PUNCT
dti-3495	346	3	α	α	X
dti-3495	346	4	-	-	NOUN
dti-3495	346	5	glucosidase	glucosidase	NOUN
dti-3495	346	6	transforms	transform	VERB
dti-3495	346	7	the	the	DET
dti-3495	346	8	disaccharides	disaccharide	NOUN
dti-3495	346	9	into	into	ADP
dti-3495	346	10	monosaccharides	monosaccharide	NOUN
dti-3495	346	11	,	,	PUNCT
dti-3495	346	12	resulting	result	VERB
dti-3495	346	13	in	in	ADP
dti-3495	346	14	elevated	elevated	ADJ
dti-3495	346	15	blood	blood	NOUN
dti-3495	346	16	glucose	glucose	NOUN
dti-3495	346	17	levels	level	NOUN
dti-3495	346	18	after	after	ADP
dti-3495	346	19	meals	meal	NOUN
dti-3495	346	20	(	(	PUNCT
dti-3495	346	21	43	43	NUM
dti-3495	346	22	)	)	PUNCT
dti-3495	346	23	.	.	PUNCT
dti-3495	347	1	delaying	delay	VERB
dti-3495	347	2	the	the	DET
dti-3495	347	3	digestion	digestion	NOUN
dti-3495	347	4	of	of	ADP
dti-3495	347	5	carbohydrates	carbohydrate	NOUN
dti-3495	347	6	and	and	CCONJ
dti-3495	347	7	reducing	reduce	VERB
dti-3495	347	8	postprandial	postprandial	ADJ
dti-3495	347	9	glucose	glucose	NOUN
dti-3495	347	10	levels	level	NOUN
dti-3495	347	11	,	,	PUNCT
dti-3495	347	12	inhibitors	inhibitor	NOUN
dti-3495	347	13	of	of	ADP
dti-3495	347	14	alpha	alpha	NOUN
dti-3495	347	15	-	-	PUNCT
dti-3495	347	16	amylase	amylase	NOUN
dti-3495	347	17	and	and	CCONJ
dti-3495	347	18	alpha	alpha	NOUN
dti-3495	347	19	-	-	PUNCT
dti-3495	347	20	glucosidase	glucosidase	ADJ
dti-3495	347	21	aid	aid	NOUN
dti-3495	347	22	in	in	ADP
dti-3495	347	23	controlling	control	VERB
dti-3495	347	24	high	high	ADJ
dti-3495	347	25	plasma	plasma	NOUN
dti-3495	347	26	glucose	glucose	NOUN
dti-3495	347	27	levels	level	NOUN
dti-3495	347	28	.	.	PUNCT
dti-3495	348	1	investigators	investigator	NOUN
dti-3495	348	2	typically	typically	ADV
dti-3495	348	3	seek	seek	VERB
dti-3495	348	4	out	out	ADP
dti-3495	348	5	natural	natural	ADJ
dti-3495	348	6	substances	substance	NOUN
dti-3495	348	7	that	that	PRON
dti-3495	348	8	can	can	AUX
dti-3495	348	9	control	control	VERB
dti-3495	348	10	elevated	elevated	ADJ
dti-3495	348	11	blood	blood	NOUN
dti-3495	348	12	sugar	sugar	NOUN
dti-3495	348	13	levels	level	NOUN
dti-3495	348	14	by	by	ADP
dti-3495	348	15	reducing	reduce	VERB
dti-3495	348	16	the	the	DET
dti-3495	348	17	activity	activity	NOUN
dti-3495	348	18	of	of	ADP
dti-3495	348	19	alpha	alpha	NOUN
dti-3495	348	20	-	-	PUNCT
dti-3495	348	21	glucosidase	glucosidase	ADJ
dti-3495	348	22	and	and	CCONJ
dti-3495	348	23	alpha	alpha	NOUN
dti-3495	348	24	-	-	PUNCT
dti-3495	348	25	amylase	amylase	NOUN
dti-3495	348	26	,	,	PUNCT
dti-3495	348	27	leading	lead	VERB
dti-3495	348	28	to	to	AUX
dti-3495	348	29	decreased	decrease	VERB
dti-3495	348	30	adverse	adverse	ADJ
dti-3495	348	31	effects	effect	NOUN
dti-3495	348	32	such	such	ADJ
dti-3495	348	33	as	as	ADP
dti-3495	348	34	diarrhea	diarrhea	NOUN
dti-3495	348	35	,	,	PUNCT
dti-3495	348	36	nausea	nausea	NOUN
dti-3495	348	37	,	,	PUNCT
dti-3495	348	38	and	and	CCONJ
dti-3495	348	39	abdominal	abdominal	ADJ
dti-3495	348	40	pain	pain	NOUN
dti-3495	348	41	(	(	PUNCT
dti-3495	348	42	44	44	NUM
dti-3495	348	43	)	)	PUNCT
dti-3495	348	44	.	.	PUNCT
dti-3495	349	1	during	during	ADP
dti-3495	349	2	an	an	DET
dti-3495	349	3	in	in	ADP
dti-3495	349	4	vitro	vitro	X
dti-3495	349	5	study	study	NOUN
dti-3495	349	6	,	,	PUNCT
dti-3495	349	7	researchers	researcher	NOUN
dti-3495	349	8	analyzed	analyze	VERB
dti-3495	349	9	cowpea	cowpea	NOUN
dti-3495	349	10	protein	protein	NOUN
dti-3495	349	11	hydrolysates	hydrolysate	NOUN
dti-3495	349	12	(	(	PUNCT
dti-3495	349	13	ph	ph	NOUN
dti-3495	349	14	)	)	PUNCT
dti-3495	349	15	and	and	CCONJ
dti-3495	349	16	ultrafiltered	ultrafiltered	ADJ
dti-3495	349	17	peptide	peptide	NOUN
dti-3495	349	18	fractions	fraction	NOUN
dti-3495	349	19	(	(	PUNCT
dti-3495	349	20	ufpf	ufpf	NOUN
dti-3495	349	21	)	)	PUNCT
dti-3495	349	22	for	for	ADP
dti-3495	349	23	their	their	PRON
dti-3495	349	24	ability	ability	NOUN
dti-3495	349	25	to	to	PART
dti-3495	349	26	inhibit	inhibit	VERB
dti-3495	349	27	enzymes	enzyme	NOUN
dti-3495	349	28	like	like	ADP
dti-3495	349	29	α	α	NOUN
dti-3495	349	30	-	-	NOUN
dti-3495	349	31	amylase	amylase	NOUN
dti-3495	349	32	,	,	PUNCT
dti-3495	349	33	α	α	NOUN
dti-3495	349	34	-	-	NOUN
dti-3495	349	35	glucosidase	glucosidase	ADJ
dti-3495	349	36	,	,	PUNCT
dti-3495	349	37	and	and	CCONJ
dti-3495	349	38	dipeptidyl	dipeptidyl	VERB
dti-3495	349	39	peptidase	peptidase	NOUN
dti-3495	349	40	iv	iv	NOUN
dti-3495	349	41	.	.	PUNCT
dti-3495	350	1	the	the	DET
dti-3495	350	2	findings	finding	NOUN
dti-3495	350	3	indicated	indicate	VERB
dti-3495	350	4	that	that	SCONJ
dti-3495	350	5	both	both	DET
dti-3495	350	6	ph	ph	NOUN
dti-3495	350	7	and	and	CCONJ
dti-3495	350	8	ufpf	ufpf	NOUN
dti-3495	350	9	demonstrated	demonstrate	VERB
dti-3495	350	10	the	the	DET
dti-3495	350	11	most	most	ADV
dti-3495	350	12	potent	potent	ADJ
dti-3495	350	13	inhibitory	inhibitory	ADJ
dti-3495	350	14	activity	activity	NOUN
dti-3495	350	15	against	against	ADP
dti-3495	350	16	the	the	DET
dti-3495	350	17	enzymes	enzyme	NOUN
dti-3495	350	18	under	under	ADP
dti-3495	350	19	investigation	investigation	NOUN
dti-3495	350	20	(	(	PUNCT
dti-3495	350	21	45	45	NUM
dti-3495	350	22	)	)	PUNCT
dti-3495	350	23	.	.	PUNCT
dti-3495	351	1	a	a	DET
dti-3495	351	2	different	different	ADJ
dti-3495	351	3	research	research	NOUN
dti-3495	351	4	study	study	NOUN
dti-3495	351	5	found	find	VERB
dti-3495	351	6	that	that	SCONJ
dti-3495	351	7	cowpea	cowpea	NOUN
dti-3495	351	8	seed	seed	NOUN
dti-3495	351	9	protein	protein	NOUN
dti-3495	351	10	hydrolysates	hydrolysate	NOUN
dti-3495	351	11	demonstrated	demonstrate	VERB
dti-3495	351	12	greater	great	ADJ
dti-3495	351	13	effectiveness	effectiveness	NOUN
dti-3495	351	14	in	in	ADP
dti-3495	351	15	inhibiting	inhibit	VERB
dti-3495	351	16	α	α	NOUN
dti-3495	351	17	-	-	NOUN
dti-3495	351	18	amylase	amylase	NOUN
dti-3495	351	19	(	(	PUNCT
dti-3495	351	20	46	46	NUM
dti-3495	351	21	)	)	PUNCT
dti-3495	351	22	.	.	PUNCT
dti-3495	352	1	the	the	DET
dti-3495	352	2	efficacy	efficacy	NOUN
dti-3495	352	3	of	of	ADP
dti-3495	352	4	sorghum	sorghum	NOUN
dti-3495	352	5	-	-	PUNCT
dti-3495	352	6	cowpea	cowpea	NOUN
dti-3495	352	7	composite	composite	ADJ
dti-3495	352	8	biscuits	biscuit	NOUN
dti-3495	352	9	in	in	ADP
dti-3495	352	10	inhibiting	inhibit	VERB
dti-3495	352	11	starch	starch	NOUN
dti-3495	352	12	hydrolysis	hydrolysis	NOUN
dti-3495	352	13	enzymes	enzyme	NOUN
dti-3495	352	14	like	like	ADP
dti-3495	352	15	α	α	NOUN
dti-3495	352	16	-	-	NOUN
dti-3495	352	17	amylase	amylase	NOUN
dti-3495	352	18	and	and	CCONJ
dti-3495	352	19	α	α	NOUN
dti-3495	352	20	-	-	NOUN
dti-3495	352	21	glucosidase	glucosidase	PROPN
dti-3495	352	22	was	be	AUX
dti-3495	352	23	examined	examine	VERB
dti-3495	352	24	.	.	PUNCT
dti-3495	353	1	this	this	DET
dti-3495	353	2	combination	combination	NOUN
dti-3495	353	3	could	could	AUX
dti-3495	353	4	potentially	potentially	ADV
dti-3495	353	5	contribute	contribute	VERB
dti-3495	353	6	to	to	ADP
dti-3495	353	7	the	the	DET
dti-3495	353	8	reduction	reduction	NOUN
dti-3495	353	9	of	of	ADP
dti-3495	353	10	postprandial	postprandial	ADJ
dti-3495	353	11	hyperglycemia	hyperglycemia	NOUN
dti-3495	353	12	by	by	ADP
dti-3495	353	13	targeting	target	VERB
dti-3495	353	14	specific	specific	ADJ
dti-3495	353	15	enzymes	enzyme	NOUN
dti-3495	353	16	(	(	PUNCT
dti-3495	353	17	47	47	NUM
dti-3495	353	18	)	)	PUNCT
dti-3495	353	19	.	.	PUNCT
dti-3495	354	1	aldose	aldose	PROPN
dti-3495	354	2	reductase	reductase	NOUN
dti-3495	354	3	can	can	AUX
dti-3495	354	4	be	be	AUX
dti-3495	354	5	found	find	VERB
dti-3495	354	6	in	in	ADP
dti-3495	354	7	almost	almost	ADV
dti-3495	354	8	all	all	PRON
dti-3495	354	9	mammalian	mammalian	ADJ
dti-3495	354	10	cells	cell	NOUN
dti-3495	354	11	,	,	PUNCT
dti-3495	354	12	with	with	ADP
dti-3495	354	13	significantly	significantly	ADV
dti-3495	354	14	higher	high	ADJ
dti-3495	354	15	levels	level	NOUN
dti-3495	354	16	in	in	ADP
dti-3495	354	17	organs	organ	NOUN
dti-3495	354	18	such	such	ADJ
dti-3495	354	19	as	as	ADP
dti-3495	354	20	the	the	DET
dti-3495	354	21	cornea	cornea	NOUN
dti-3495	354	22	,	,	PUNCT
dti-3495	354	23	retina	retina	NOUN
dti-3495	354	24	,	,	PUNCT
dti-3495	354	25	lens	len	NOUN
dti-3495	354	26	,	,	PUNCT
dti-3495	354	27	myelin	myelin	NOUN
dti-3495	354	28	sheath	sheath	NOUN
dti-3495	354	29	,	,	PUNCT
dti-3495	354	30	kidney	kidney	NOUN
dti-3495	354	31	,	,	PUNCT
dti-3495	354	32	and	and	CCONJ
dti-3495	354	33	sciatic	sciatic	ADJ
dti-3495	354	34	nerves	nerve	NOUN
dti-3495	354	35	.	.	PUNCT
dti-3495	355	1	these	these	DET
dti-3495	355	2	organs	organ	NOUN
dti-3495	355	3	are	be	AUX
dti-3495	355	4	prone	prone	ADJ
dti-3495	355	5	to	to	ADP
dti-3495	355	6	diabetic	diabetic	ADJ
dti-3495	355	7	complications	complication	NOUN
dti-3495	355	8	(	(	PUNCT
dti-3495	355	9	48	48	NUM
dti-3495	355	10	)	)	PUNCT
dti-3495	355	11	.	.	PUNCT
dti-3495	356	1	the	the	DET
dti-3495	356	2	accumulation	accumulation	NOUN
dti-3495	356	3	of	of	ADP
dti-3495	356	4	polyol	polyol	NOUN
dti-3495	356	5	in	in	ADP
dti-3495	356	6	lens	lens	NOUN
dti-3495	356	7	fibers	fiber	NOUN
dti-3495	356	8	,	,	PUNCT
dti-3495	356	9	due	due	ADP
dti-3495	356	10	to	to	ADP
dti-3495	356	11	the	the	DET
dti-3495	356	12	heightened	heighten	VERB
dti-3495	356	13	activity	activity	NOUN
dti-3495	356	14	of	of	ADP
dti-3495	356	15	the	the	DET
dti-3495	356	16	polyol	polyol	NOUN
dti-3495	356	17	pathway	pathway	NOUN
dti-3495	356	18	,	,	PUNCT
dti-3495	356	19	results	result	VERB
dti-3495	356	20	in	in	ADP
dti-3495	356	21	the	the	DET
dti-3495	356	22	influx	influx	NOUN
dti-3495	356	23	of	of	ADP
dti-3495	356	24	water	water	NOUN
dti-3495	356	25	and	and	CCONJ
dti-3495	356	26	the	the	DET
dti-3495	356	27	generation	generation	NOUN
dti-3495	356	28	of	of	ADP
dti-3495	356	29	osmotic	osmotic	ADJ
dti-3495	356	30	stress	stress	NOUN
dti-3495	356	31	.	.	PUNCT
dti-3495	357	1	consequently	consequently	ADV
dti-3495	357	2	,	,	PUNCT
dti-3495	357	3	this	this	PRON
dti-3495	357	4	leads	lead	VERB
dti-3495	357	5	to	to	ADP
dti-3495	357	6	tissue	tissue	NOUN
dti-3495	357	7	damage	damage	NOUN
dti-3495	357	8	through	through	ADP
dti-3495	357	9	osmotic	osmotic	ADJ
dti-3495	357	10	swelling	swelling	NOUN
dti-3495	357	11	,	,	PUNCT
dti-3495	357	12	changes	change	NOUN
dti-3495	357	13	in	in	ADP
dti-3495	357	14	membrane	membrane	NOUN
dti-3495	357	15	permeability	permeability	NOUN
dti-3495	357	16	,	,	PUNCT
dti-3495	357	17	and	and	CCONJ
dti-3495	357	18	oxidative	oxidative	ADJ
dti-3495	357	19	stress	stress	NOUN
dti-3495	357	20	.	.	PUNCT
dti-3495	358	1	the	the	DET
dti-3495	358	2	polyol	polyol	NOUN
dti-3495	358	3	pathway	pathway	NOUN
dti-3495	358	4	has	have	AUX
dti-3495	358	5	garnered	garner	VERB
dti-3495	358	6	considerable	considerable	ADJ
dti-3495	358	7	focus	focus	NOUN
dti-3495	358	8	in	in	ADP
dti-3495	358	9	the	the	DET
dti-3495	358	10	clinical	clinical	ADJ
dti-3495	358	11	treatment	treatment	NOUN
dti-3495	358	12	of	of	ADP
dti-3495	358	13	secondary	secondary	ADJ
dti-3495	358	14	diabetes	diabetes	NOUN
dti-3495	358	15	complications	complication	NOUN
dti-3495	358	16	because	because	SCONJ
dti-3495	358	17	of	of	ADP
dti-3495	358	18	these	these	DET
dti-3495	358	19	outcomes	outcome	NOUN
dti-3495	358	20	(	(	PUNCT
dti-3495	358	21	49	49	NUM
dti-3495	358	22	)	)	PUNCT
dti-3495	358	23	.	.	PUNCT
dti-3495	359	1	the	the	DET
dti-3495	359	2	breakdown	breakdown	NOUN
dti-3495	359	3	of	of	ADP
dti-3495	359	4	glucose	glucose	NOUN
dti-3495	359	5	through	through	ADP
dti-3495	359	6	the	the	DET
dti-3495	359	7	polyol	polyol	NOUN
dti-3495	359	8	pathway	pathway	NOUN
dti-3495	359	9	by	by	ADP
dti-3495	359	10	enzymes	enzyme	NOUN
dti-3495	359	11	leads	lead	VERB
dti-3495	359	12	to	to	ADP
dti-3495	359	13	the	the	DET
dti-3495	359	14	production	production	NOUN
dti-3495	359	15	of	of	ADP
dti-3495	359	16	sorbitol	sorbitol	NOUN
dti-3495	359	17	,	,	PUNCT
dti-3495	359	18	which	which	PRON
dti-3495	359	19	is	be	AUX
dti-3495	359	20	a	a	DET
dti-3495	359	21	harmful	harmful	ADJ
dti-3495	359	22	substance	substance	NOUN
dti-3495	359	23	for	for	ADP
dti-3495	359	24	tissues	tissue	NOUN
dti-3495	359	25	as	as	SCONJ
dti-3495	359	26	it	it	PRON
dti-3495	359	27	increases	increase	VERB
dti-3495	359	28	osmotic	osmotic	ADJ
dti-3495	359	29	pressure	pressure	NOUN
dti-3495	359	30	and	and	CCONJ
dti-3495	359	31	can	can	AUX
dti-3495	359	32	cause	cause	VERB
dti-3495	359	33	tissue	tissue	NOUN
dti-3495	359	34	swelling	swelling	NOUN
dti-3495	359	35	.	.	PUNCT
dti-3495	360	1	by	by	ADP
dti-3495	360	2	inhibiting	inhibit	VERB
dti-3495	360	3	the	the	DET
dti-3495	360	4	activity	activity	NOUN
dti-3495	360	5	of	of	ADP
dti-3495	360	6	aldose	aldose	DET
dti-3495	360	7	reductase	reductase	NOUN
dti-3495	360	8	,	,	PUNCT
dti-3495	360	9	which	which	PRON
dti-3495	360	10	is	be	AUX
dti-3495	360	11	mainly	mainly	ADV
dti-3495	360	12	present	present	ADJ
dti-3495	360	13	in	in	ADP
dti-3495	360	14	the	the	DET
dti-3495	360	15	lens	len	NOUN
dti-3495	360	16	’s	’s	PART
dti-3495	360	17	epithelial	epithelial	ADJ
dti-3495	360	18	cells	cell	NOUN
dti-3495	360	19	,	,	PUNCT
dti-3495	360	20	it	it	PRON
dti-3495	360	21	is	be	AUX
dti-3495	360	22	possible	possible	ADJ
dti-3495	360	23	to	to	PART
dti-3495	360	24	prevent	prevent	VERB
dti-3495	360	25	the	the	DET
dti-3495	360	26	development	development	NOUN
dti-3495	360	27	of	of	ADP
dti-3495	360	28	cataracts	cataract	NOUN
dti-3495	360	29	(	(	PUNCT
dti-3495	360	30	23	23	NUM
dti-3495	360	31	)	)	PUNCT
dti-3495	360	32	.	.	PUNCT
dti-3495	361	1	the	the	DET
dti-3495	361	2	literature	literature	NOUN
dti-3495	361	3	does	do	AUX
dti-3495	361	4	not	not	PART
dti-3495	361	5	contain	contain	VERB
dti-3495	361	6	any	any	DET
dti-3495	361	7	data	datum	NOUN
dti-3495	361	8	on	on	ADP
dti-3495	361	9	the	the	DET
dti-3495	361	10	in	in	X
dti-3495	361	11	vitro	vitro	X
dti-3495	361	12	anti	anti	ADJ
dti-3495	361	13	-	-	ADJ
dti-3495	361	14	diabetic	diabetic	ADJ
dti-3495	361	15	properties	property	NOUN
dti-3495	361	16	,	,	PUNCT
dti-3495	361	17	such	such	ADJ
dti-3495	361	18	as	as	ADP
dti-3495	361	19	the	the	DET
dti-3495	361	20	inhibition	inhibition	NOUN
dti-3495	361	21	of	of	ADP
dti-3495	361	22	α	α	NOUN
dti-3495	361	23	-	-	NOUN
dti-3495	361	24	amylase	amylase	NOUN
dti-3495	361	25	,	,	PUNCT
dti-3495	361	26	α	α	NOUN
dti-3495	361	27	-	-	NOUN
dti-3495	361	28	glucosidase	glucosidase	NOUN
dti-3495	361	29	,	,	PUNCT
dti-3495	361	30	and	and	CCONJ
dti-3495	361	31	aldose	aldose	PRON
dti-3495	361	32	reductase	reductase	NOUN
dti-3495	361	33	activities	activity	NOUN
dti-3495	361	34	,	,	PUNCT
dti-3495	361	35	of	of	ADP
dti-3495	361	36	the	the	DET
dti-3495	361	37	entire	entire	ADJ
dti-3495	361	38	v.	v.	ADP
dti-3495	361	39	unguiculata	unguiculata	ADJ
dti-3495	361	40	plant	plant	NOUN
dti-3495	361	41	.	.	PUNCT
dti-3495	362	1	therefore	therefore	ADV
dti-3495	362	2	,	,	PUNCT
dti-3495	362	3	our	our	PRON
dti-3495	362	4	current	current	ADJ
dti-3495	362	5	study	study	NOUN
dti-3495	362	6	aims	aim	VERB
dti-3495	362	7	to	to	PART
dti-3495	362	8	assess	assess	VERB
dti-3495	362	9	the	the	DET
dti-3495	362	10	ability	ability	NOUN
dti-3495	362	11	of	of	ADP
dti-3495	362	12	the	the	DET
dti-3495	362	13	whole	whole	ADJ
dti-3495	362	14	v.	v.	ADP
dti-3495	362	15	unguiculata	unguiculata	ADJ
dti-3495	362	16	plant	plant	NOUN
dti-3495	362	17	to	to	PART
dti-3495	362	18	inhibit	inhibit	VERB
dti-3495	362	19	alpha	alpha	ADJ
dti-3495	362	20	amylase	amylase	NOUN
dti-3495	362	21	,	,	PUNCT
dti-3495	362	22	alpha	alpha	NOUN
dti-3495	362	23	glucosidase	glucosidase	NOUN
dti-3495	362	24	,	,	PUNCT
dti-3495	362	25	and	and	CCONJ
dti-3495	362	26	aldose	aldose	PRON
dti-3495	362	27	reductase	reductase	NOUN
dti-3495	362	28	enzymes	enzyme	NOUN
dti-3495	362	29	.	.	PUNCT
dti-3495	363	1	among	among	ADP
dti-3495	363	2	all	all	DET
dti-3495	363	3	the	the	DET
dti-3495	363	4	samples	sample	NOUN
dti-3495	363	5	tested	test	VERB
dti-3495	363	6	,	,	PUNCT
dti-3495	363	7	the	the	DET
dti-3495	363	8	crude	crude	ADJ
dti-3495	363	9	extract	extract	NOUN
dti-3495	363	10	exhibited	exhibit	VERB
dti-3495	363	11	the	the	DET
dti-3495	363	12	most	most	ADV
dti-3495	363	13	significant	significant	ADJ
dti-3495	363	14	inhibitory	inhibitory	ADJ
dti-3495	363	15	activity	activity	NOUN
dti-3495	363	16	against	against	ADP
dti-3495	363	17	alpha	alpha	NOUN
dti-3495	363	18	amylase	amylase	NOUN
dti-3495	363	19	,	,	PUNCT
dti-3495	363	20	alpha	alpha	NOUN
dti-3495	363	21	glucosidase	glucosidase	NOUN
dti-3495	363	22	,	,	PUNCT
dti-3495	363	23	and	and	CCONJ
dti-3495	363	24	aldose	aldose	PRON
dti-3495	363	25	reductase	reductase	NOUN
dti-3495	363	26	with	with	ADP
dti-3495	363	27	ic50	ic50	PROPN
dti-3495	363	28	values	value	NOUN
dti-3495	363	29	of	of	ADP
dti-3495	363	30	0.202	0.202	NUM
dti-3495	363	31	mg	mg	PROPN
dti-3495	363	32	/	/	SYM
dti-3495	363	33	ml	ml	PROPN
dti-3495	363	34	,	,	PUNCT
dti-3495	363	35	0.111	0.111	NUM
dti-3495	363	36	mg	mg	PROPN
dti-3495	363	37	/	/	SYM
dti-3495	363	38	ml	ml	PROPN
dti-3495	363	39	and	and	CCONJ
dti-3495	363	40	15.823	15.823	NUM
dti-3495	363	41	µg	µg	ADJ
dti-3495	363	42	/	/	SYM
dti-3495	363	43	ml	ml	NOUN
dti-3495	363	44	,	,	PUNCT
dti-3495	363	45	respectively	respectively	ADV
dti-3495	363	46	.	.	PUNCT
dti-3495	364	1	moreover	moreover	ADV
dti-3495	364	2	,	,	PUNCT
dti-3495	364	3	the	the	DET
dti-3495	364	4	current	current	ADJ
dti-3495	364	5	study	study	NOUN
dti-3495	364	6	also	also	ADV
dti-3495	364	7	used	use	VERB
dti-3495	364	8	a	a	DET
dti-3495	364	9	network	network	NOUN
dti-3495	364	10	pharmacology	pharmacology	NOUN
dti-3495	364	11	approach	approach	NOUN
dti-3495	364	12	to	to	PART
dti-3495	364	13	come	come	VERB
dti-3495	364	14	up	up	ADP
dti-3495	364	15	with	with	ADP
dti-3495	364	16	a	a	DET
dti-3495	364	17	complex	complex	ADJ
dti-3495	364	18	network	network	NOUN
dti-3495	364	19	connecting	connect	VERB
dti-3495	364	20	the	the	DET
dti-3495	364	21	compounds	compound	NOUN
dti-3495	364	22	of	of	ADP
dti-3495	364	23	v.	v.	ADP
dti-3495	364	24	unguiculata	unguiculata	PROPN
dti-3495	364	25	and	and	CCONJ
dti-3495	364	26	the	the	DET
dti-3495	364	27	potential	potential	ADJ
dti-3495	364	28	protein	protein	NOUN
dti-3495	364	29	targets	target	NOUN
dti-3495	364	30	.	.	PUNCT
dti-3495	365	1	unlike	unlike	ADP
dti-3495	365	2	most	most	ADJ
dti-3495	365	3	previous	previous	ADJ
dti-3495	365	4	studies	study	NOUN
dti-3495	365	5	that	that	PRON
dti-3495	365	6	focus	focus	VERB
dti-3495	365	7	on	on	ADP
dti-3495	365	8	single	single	ADJ
dti-3495	365	9	-	-	PUNCT
dti-3495	365	10	target	target	NOUN
dti-3495	365	11	drugs	drug	NOUN
dti-3495	365	12	,	,	PUNCT
dti-3495	365	13	our	our	PRON
dti-3495	365	14	approach	approach	NOUN
dti-3495	365	15	considers	consider	VERB
dti-3495	365	16	multiple	multiple	ADJ
dti-3495	365	17	targets	target	NOUN
dti-3495	365	18	and	and	CCONJ
dti-3495	365	19	their	their	PRON
dti-3495	365	20	interactions	interaction	NOUN
dti-3495	365	21	,	,	PUNCT
dti-3495	365	22	including	include	VERB
dti-3495	365	23	those	those	PRON
dti-3495	365	24	with	with	ADP
dti-3495	365	25	t2	t2	NOUN
dti-3495	365	26	dm	dm	PROPN
dti-3495	365	27	.	.	PUNCT
dti-3495	366	1	for	for	ADP
dti-3495	366	2	instance	instance	NOUN
dti-3495	366	3	,	,	PUNCT
dti-3495	366	4	previous	previous	ADJ
dti-3495	366	5	works	work	NOUN
dti-3495	366	6	have	have	AUX
dti-3495	366	7	defined	define	VERB
dti-3495	366	8	involvement	involvement	NOUN
dti-3495	366	9	of	of	ADP
dti-3495	366	10	proteins	protein	NOUN
dti-3495	366	11	such	such	ADJ
dti-3495	366	12	as	as	ADP
dti-3495	366	13	gsk3b	gsk3b	PROPN
dti-3495	366	14	in	in	ADP
dti-3495	366	15	insulin	insulin	NOUN
dti-3495	366	16	signaling	signal	VERB
dti-3495	366	17	and	and	CCONJ
dti-3495	366	18	glucose	glucose	NOUN
dti-3495	366	19	metabolism	metabolism	NOUN
dti-3495	366	20	,	,	PUNCT
dti-3495	366	21	but	but	CCONJ
dti-3495	366	22	this	this	DET
dti-3495	366	23	work	work	NOUN
dti-3495	366	24	affords	afford	VERB
dti-3495	366	25	elaborate	elaborate	ADJ
dti-3495	366	26	information	information	NOUN
dti-3495	366	27	to	to	ADP
dti-3495	366	28	how	how	SCONJ
dti-3495	366	29	multiple	multiple	ADJ
dti-3495	366	30	compounds	compound	NOUN
dti-3495	366	31	influence	influence	PROPN
dti-3495	366	32	gsk3b	gsk3b	PROPN
dti-3495	366	33	,	,	PUNCT
dti-3495	366	34	ptgs2	ptgs2	PROPN
dti-3495	366	35	,	,	PUNCT
dti-3495	366	36	and	and	CCONJ
dti-3495	366	37	tlr4	tlr4	NOUN
dti-3495	366	38	at	at	ADP
dti-3495	366	39	the	the	DET
dti-3495	366	40	same	same	ADJ
dti-3495	366	41	time	time	NOUN
dti-3495	366	42	.	.	PUNCT
dti-3495	367	1	this	this	DET
dti-3495	367	2	multiple	multiple	ADJ
dti-3495	367	3	-	-	PUNCT
dti-3495	367	4	target	target	NOUN
dti-3495	367	5	approach	approach	NOUN
dti-3495	367	6	is	be	AUX
dti-3495	367	7	in	in	ADP
dti-3495	367	8	harmony	harmony	NOUN
dti-3495	367	9	with	with	ADP
dti-3495	367	10	modern	modern	ADJ
dti-3495	367	11	practices	practice	NOUN
dti-3495	367	12	in	in	ADP
dti-3495	367	13	network	network	NOUN
dti-3495	367	14	pharmacology	pharmacology	NOUN
dti-3495	367	15	,	,	PUNCT
dti-3495	367	16	where	where	SCONJ
dti-3495	367	17	the	the	DET
dti-3495	367	18	impact	impact	NOUN
dti-3495	367	19	of	of	ADP
dti-3495	367	20	drug	drug	NOUN
dti-3495	367	21	candidates	candidate	NOUN
dti-3495	367	22	on	on	ADP
dti-3495	367	23	multiple	multiple	ADJ
dti-3495	367	24	interconnected	interconnected	ADJ
dti-3495	367	25	biological	biological	ADJ
dti-3495	367	26	targets	target	NOUN
dti-3495	367	27	is	be	AUX
dti-3495	367	28	researched	research	VERB
dti-3495	367	29	.	.	PUNCT
dti-3495	368	1	the	the	DET
dti-3495	368	2	go	go	NOUN
dti-3495	368	3	and	and	CCONJ
dti-3495	368	4	kegg	kegg	NOUN
dti-3495	368	5	study	study	NOUN
dti-3495	368	6	provides	provide	VERB
dti-3495	368	7	insight	insight	NOUN
dti-3495	368	8	into	into	ADP
dti-3495	368	9	important	important	ADJ
dti-3495	368	10	signaling	signaling	NOUN
dti-3495	368	11	,	,	PUNCT
dti-3495	368	12	including	include	VERB
dti-3495	368	13	ptgs2	ptgs2	PROPN
dti-3495	368	14	,	,	PUNCT
dti-3495	368	15	gsk3b	gsk3b	PROPN
dti-3495	368	16	,	,	PUNCT
dti-3495	368	17	and	and	CCONJ
dti-3495	368	18	tlr4	tlr4	NOUN
dti-3495	368	19	,	,	PUNCT
dti-3495	368	20	which	which	PRON
dti-3495	368	21	are	be	AUX
dti-3495	368	22	influenced	influence	VERB
dti-3495	368	23	by	by	ADP
dti-3495	368	24	the	the	DET
dti-3495	368	25	v.	v.	PROPN
dti-3495	368	26	unguiculata	unguiculata	ADJ
dti-3495	368	27	constituents	constituent	NOUN
dti-3495	368	28	and	and	CCONJ
dti-3495	368	29	evidently	evidently	ADV
dti-3495	368	30	support	support	VERB
dti-3495	368	31	the	the	DET
dti-3495	368	32	potential	potential	ADJ
dti-3495	368	33	multi	multi	ADJ
dti-3495	368	34	-	-	ADJ
dti-3495	368	35	target	target	ADJ
dti-3495	368	36	anti	anti	ADJ
dti-3495	368	37	-	-	ADJ
dti-3495	368	38	diabetic	diabetic	ADJ
dti-3495	368	39	activity	activity	NOUN
dti-3495	368	40	.	.	PUNCT
dti-3495	369	1	however	however	ADV
dti-3495	369	2	,	,	PUNCT
dti-3495	369	3	the	the	DET
dti-3495	369	4	multi	multi	ADJ
dti-3495	369	5	-	-	ADJ
dti-3495	369	6	target	target	NOUN
dti-3495	369	7	analysis	analysis	NOUN
dti-3495	369	8	conducted	conduct	VERB
dti-3495	369	9	in	in	ADP
dti-3495	369	10	this	this	DET
dti-3495	369	11	study	study	NOUN
dti-3495	369	12	increases	increase	VERB
dti-3495	369	13	the	the	DET
dti-3495	369	14	likelihood	likelihood	NOUN
dti-3495	369	15	of	of	ADP
dti-3495	369	16	off	off	ADP
dti-3495	369	17	-	-	PUNCT
dti-3495	369	18	target	target	NOUN
dti-3495	369	19	effects	effect	NOUN
dti-3495	369	20	and	and	CCONJ
dti-3495	369	21	paves	pave	VERB
dti-3495	369	22	the	the	DET
dti-3495	369	23	way	way	NOUN
dti-3495	369	24	for	for	ADP
dti-3495	369	25	undesired	undesired	ADJ
dti-3495	369	26	biological	biological	ADJ
dti-3495	369	27	responses	response	NOUN
dti-3495	369	28	.	.	PUNCT
dti-3495	370	1	furthermore	furthermore	ADV
dti-3495	370	2	,	,	PUNCT
dti-3495	370	3	the	the	DET
dti-3495	370	4	non	non	ADJ
dti-3495	370	5	-	-	ADJ
dti-3495	370	6	specific	specific	ADJ
dti-3495	370	7	interactions	interaction	NOUN
dti-3495	370	8	of	of	ADP
dti-3495	370	9	the	the	DET
dti-3495	370	10	studied	study	VERB
dti-3495	370	11	protein	protein	NOUN
dti-3495	370	12	with	with	ADP
dti-3495	370	13	multiple	multiple	ADJ
dti-3495	370	14	signaling	signal	VERB
dti-3495	370	15	protein	protein	NOUN
dti-3495	370	16	may	may	AUX
dti-3495	370	17	alter	alter	VERB
dti-3495	370	18	biological	biological	ADJ
dti-3495	370	19	responses	response	NOUN
dti-3495	370	20	and	and	CCONJ
dti-3495	370	21	produce	produce	VERB
dti-3495	370	22	adverse	adverse	ADJ
dti-3495	370	23	effects	effect	NOUN
dti-3495	370	24	.	.	PUNCT
dti-3495	371	1	this	this	DET
dti-3495	371	2	study	study	NOUN
dti-3495	371	3	focused	focus	VERB
dti-3495	371	4	on	on	ADP
dti-3495	371	5	the	the	DET
dti-3495	371	6	computational	computational	ADJ
dti-3495	371	7	predictions	prediction	NOUN
dti-3495	371	8	and	and	CCONJ
dti-3495	371	9	in	in	ADP
dti-3495	371	10	vitro	vitro	X
dti-3495	371	11	analysis	analysis	NOUN
dti-3495	371	12	;	;	PUNCT
dti-3495	371	13	however	however	ADV
dti-3495	371	14	,	,	PUNCT
dti-3495	371	15	to	to	PART
dti-3495	371	16	validate	validate	VERB
dti-3495	371	17	the	the	DET
dti-3495	371	18	safety	safety	NOUN
dti-3495	371	19	and	and	CCONJ
dti-3495	371	20	specificity	specificity	NOUN
dti-3495	371	21	of	of	ADP
dti-3495	371	22	the	the	DET
dti-3495	371	23	compounds	compound	NOUN
dti-3495	371	24	,	,	PUNCT
dti-3495	371	25	in	in	ADP
dti-3495	371	26	vivo	vivo	NOUN
dti-3495	371	27	and	and	CCONJ
dti-3495	371	28	in	in	ADP
dti-3495	371	29	vitro	vitro	X
dti-3495	371	30	studies	study	NOUN
dti-3495	371	31	will	will	AUX
dti-3495	371	32	be	be	AUX
dti-3495	371	33	required	require	VERB
dti-3495	371	34	.	.	PUNCT
dti-3495	372	1	gsk3b	gsk3b	PROPN
dti-3495	372	2	is	be	AUX
dti-3495	372	3	implicated	implicate	VERB
dti-3495	372	4	in	in	ADP
dti-3495	372	5	insulin	insulin	NOUN
dti-3495	372	6	signaling	signaling	NOUN
dti-3495	372	7	and	and	CCONJ
dti-3495	372	8	glucose	glucose	NOUN
dti-3495	372	9	homeostasis	homeostasis	NOUN
dti-3495	372	10	.	.	PUNCT
dti-3495	373	1	several	several	ADJ
dti-3495	373	2	studies	study	NOUN
dti-3495	373	3	have	have	AUX
dti-3495	373	4	revealed	reveal	VERB
dti-3495	373	5	that	that	SCONJ
dti-3495	373	6	gsk3b	gsk3b	PROPN
dti-3495	373	7	knockdown	knockdown	NOUN
dti-3495	373	8	promotes	promote	VERB
dti-3495	373	9	insulin	insulin	NOUN
dti-3495	373	10	signaling	signal	VERB
dti-3495	373	11	and	and	CCONJ
dti-3495	373	12	corrects	correct	VERB
dti-3495	373	13	glucose	glucose	NOUN
dti-3495	373	14	intolerance	intolerance	NOUN
dti-3495	373	15	in	in	ADP
dti-3495	373	16	diabetic	diabetic	ADJ
dti-3495	373	17	animal	animal	NOUN
dti-3495	373	18	models	model	NOUN
dti-3495	373	19	.	.	PUNCT
dti-3495	374	1	inhibition	inhibition	NOUN
dti-3495	374	2	of	of	ADP
dti-3495	374	3	gsk3b	gsk3b	PROPN
dti-3495	374	4	is	be	AUX
dti-3495	374	5	important	important	ADJ
dti-3495	374	6	for	for	ADP
dti-3495	374	7	regulating	regulate	VERB
dti-3495	374	8	hyperglycemia	hyperglycemia	NOUN
dti-3495	374	9	and	and	CCONJ
dti-3495	374	10	insulin	insulin	NOUN
dti-3495	374	11	resistance	resistance	NOUN
dti-3495	374	12	since	since	SCONJ
dti-3495	374	13	it	it	PRON
dti-3495	374	14	is	be	AUX
dti-3495	374	15	targeted	target	VERB
dti-3495	374	16	by	by	ADP
dti-3495	374	17	these	these	DET
dti-3495	374	18	inhibitors	inhibitor	NOUN
dti-3495	374	19	(	(	PUNCT
dti-3495	374	20	50	50	NUM
dti-3495	374	21	)	)	PUNCT
dti-3495	374	22	.	.	PUNCT
dti-3495	375	1	similarly	similarly	ADV
dti-3495	375	2	,	,	PUNCT
dti-3495	375	3	ptgs2	ptgs2	PROPN
dti-3495	375	4	,	,	PUNCT
dti-3495	375	5	commonly	commonly	ADV
dti-3495	375	6	known	know	VERB
dti-3495	375	7	as	as	ADP
dti-3495	375	8	cox-2	cox-2	NOUN
dti-3495	375	9	,	,	PUNCT
dti-3495	375	10	is	be	AUX
dti-3495	375	11	an	an	DET
dti-3495	375	12	enzyme	enzyme	NOUN
dti-3495	375	13	that	that	PRON
dti-3495	375	14	plays	play	VERB
dti-3495	375	15	a	a	DET
dti-3495	375	16	significant	significant	ADJ
dti-3495	375	17	role	role	NOUN
dti-3495	375	18	in	in	ADP
dti-3495	375	19	inflammation	inflammation	NOUN
dti-3495	375	20	(	(	PUNCT
dti-3495	375	21	51	51	NUM
dti-3495	375	22	)	)	PUNCT
dti-3495	375	23	.	.	PUNCT
dti-3495	376	1	inflammatory	inflammatory	ADJ
dti-3495	376	2	processes	process	NOUN
dti-3495	376	3	play	play	VERB
dti-3495	376	4	a	a	DET
dti-3495	376	5	crucial	crucial	ADJ
dti-3495	376	6	role	role	NOUN
dti-3495	376	7	in	in	ADP
dti-3495	376	8	the	the	DET
dti-3495	376	9	evolution	evolution	NOUN
dti-3495	376	10	and	and	CCONJ
dti-3495	376	11	progression	progression	NOUN
dti-3495	376	12	of	of	ADP
dti-3495	376	13	insulin	insulin	NOUN
dti-3495	376	14	resistance	resistance	NOUN
dti-3495	376	15	and	and	CCONJ
dti-3495	376	16	consequent	consequent	ADJ
dti-3495	376	17	type	type	NOUN
dti-3495	376	18	2	2	NUM
dti-3495	376	19	diabetes	diabetes	NOUN
dti-3495	376	20	.	.	PUNCT
dti-3495	377	1	select	select	ADJ
dti-3495	377	2	members	member	NOUN
dti-3495	377	3	of	of	ADP
dti-3495	377	4	the	the	DET
dti-3495	377	5	cox-2	cox-2	ADJ
dti-3495	377	6	enzyme	enzyme	NOUN
dti-3495	377	7	have	have	AUX
dti-3495	377	8	been	be	AUX
dti-3495	377	9	table	table	NOUN
dti-3495	377	10	8	8	NUM
dti-3495	377	11	the	the	DET
dti-3495	377	12	mm	mm	PROPN
dti-3495	377	13	-	-	PUNCT
dti-3495	377	14	gbsa	gbsa	ADJ
dti-3495	377	15	result	result	NOUN
dti-3495	377	16	of	of	ADP
dti-3495	377	17	the	the	DET
dti-3495	377	18	3fxi_quercetin	3fxi_quercetin	NUM
dti-3495	377	19	complex	complex	ADJ
dti-3495	377	20	frames	frame	NOUN
dti-3495	377	21	vdwaals	vdwaal	NOUN
dti-3495	377	22	eel	eel	VERB
dti-3495	377	23	egb	egb	PROPN
dti-3495	377	24	esurf	esurf	PROPN
dti-3495	377	25	ggas	ggas	PROPN
dti-3495	377	26	gsolv	gsolv	PROPN
dti-3495	377	27	total	total	PROPN
dti-3495	377	28	average	average	ADJ
dti-3495	377	29	−21.08	−21.08	PROPN
dti-3495	377	30	−46.49	−46.49	ADP
dti-3495	377	31	40.85	40.85	NUM
dti-3495	377	32	−3.84	−3.84	ADP
dti-3495	377	33	−67.58	−67.58	VERB
dti-3495	377	34	37.02	37.02	NUM
dti-3495	377	35	−30.56	−30.56	NOUN
dti-3495	377	36	sd	sd	ADP
dti-3495	377	37	2.85	2.85	NUM
dti-3495	377	38	5.84	5.84	NUM
dti-3495	377	39	4.6	4.6	NUM
dti-3495	377	40	0.12	0.12	NUM
dti-3495	377	41	4.95	4.95	NUM
dti-3495	377	42	4.61	4.61	NUM
dti-3495	377	43	2.3	2.3	NUM
dti-3495	377	44	sem	sem	NOUN
dti-3495	377	45	0.13	0.13	NUM
dti-3495	377	46	0.26	0.26	NUM
dti-3495	377	47	0.21	0.21	NUM
dti-3495	377	48	0.01	0.01	NUM
dti-3495	377	49	0.22	0.22	NUM
dti-3495	377	50	0.21	0.21	NUM
dti-3495	377	51	0.1	0.1	NUM
dti-3495	377	52	in	in	ADP
dti-3495	377	53	silico	silico	NOUN
dti-3495	377	54	anti	anti	ADJ
dti-3495	377	55	-	-	ADJ
dti-3495	377	56	diabetic	diabetic	ADJ
dti-3495	377	57	potential	potential	NOUN
dti-3495	377	58	of	of	ADP
dti-3495	377	59	vigna	vigna	PROPN
dti-3495	377	60	unguiculata88	unguiculata88	NOUN
dti-3495	378	1	©	©	PROPN
dti-3495	378	2	2025	2025	NUM
dti-3495	378	3	the	the	DET
dti-3495	378	4	authors	author	NOUN
dti-3495	378	5	.	.	PUNCT
dti-3495	379	1	drug	drug	NOUN
dti-3495	379	2	target	target	NOUN
dti-3495	379	3	insights	insight	NOUN
dti-3495	379	4	issn	issn	VERB
dti-3495	379	5	1177	1177	NUM
dti-3495	379	6	-	-	SYM
dti-3495	379	7	3928	3928	NUM
dti-3495	379	8	www.aboutscience.eu/dti	www.aboutscience.eu/dti	NOUN
dti-3495	379	9	studied	study	VERB
dti-3495	379	10	as	as	ADP
dti-3495	379	11	an	an	DET
dti-3495	379	12	anti	anti	ADJ
dti-3495	379	13	-	-	ADJ
dti-3495	379	14	inflammatory	inflammatory	ADJ
dti-3495	379	15	,	,	PUNCT
dti-3495	379	16	which	which	PRON
dti-3495	379	17	may	may	AUX
dti-3495	379	18	have	have	VERB
dti-3495	379	19	beneficial	beneficial	ADJ
dti-3495	379	20	effects	effect	NOUN
dti-3495	379	21	on	on	ADP
dti-3495	379	22	other	other	ADJ
dti-3495	379	23	metabolic	metabolic	NOUN
dti-3495	379	24	complications	complication	NOUN
dti-3495	379	25	related	relate	VERB
dti-3495	379	26	to	to	ADP
dti-3495	379	27	diabetes	diabetes	NOUN
dti-3495	379	28	.	.	PUNCT
dti-3495	380	1	in	in	ADP
dti-3495	380	2	contrast	contrast	NOUN
dti-3495	380	3	,	,	PUNCT
dti-3495	380	4	tlr4	tlr4	NOUN
dti-3495	380	5	contributes	contribute	VERB
dti-3495	380	6	to	to	ADP
dti-3495	380	7	the	the	DET
dti-3495	380	8	immune	immune	ADJ
dti-3495	380	9	system	system	NOUN
dti-3495	380	10	,	,	PUNCT
dti-3495	380	11	and	and	CCONJ
dti-3495	380	12	its	its	PRON
dti-3495	380	13	overactivation	overactivation	NOUN
dti-3495	380	14	is	be	AUX
dti-3495	380	15	suggested	suggest	VERB
dti-3495	380	16	to	to	PART
dti-3495	380	17	induce	induce	VERB
dti-3495	380	18	the	the	DET
dti-3495	380	19	inflammation	inflammation	NOUN
dti-3495	380	20	that	that	PRON
dti-3495	380	21	drives	drive	VERB
dti-3495	380	22	insulin	insulin	NOUN
dti-3495	380	23	resistance	resistance	NOUN
dti-3495	380	24	(	(	PUNCT
dti-3495	380	25	52	52	NUM
dti-3495	380	26	)	)	PUNCT
dti-3495	380	27	.	.	PUNCT
dti-3495	381	1	it	it	PRON
dti-3495	381	2	has	have	AUX
dti-3495	381	3	been	be	AUX
dti-3495	381	4	proposed	propose	VERB
dti-3495	381	5	that	that	SCONJ
dti-3495	381	6	using	use	VERB
dti-3495	381	7	specific	specific	ADJ
dti-3495	381	8	inhibitors	inhibitor	NOUN
dti-3495	381	9	or	or	CCONJ
dti-3495	381	10	antagonists	antagonist	NOUN
dti-3495	381	11	of	of	ADP
dti-3495	381	12	tlr4	tlr4	NOUN
dti-3495	381	13	may	may	AUX
dti-3495	381	14	present	present	VERB
dti-3495	381	15	a	a	DET
dti-3495	381	16	useful	useful	ADJ
dti-3495	381	17	strategy	strategy	NOUN
dti-3495	381	18	for	for	ADP
dti-3495	381	19	the	the	DET
dti-3495	381	20	modulation	modulation	NOUN
dti-3495	381	21	of	of	ADP
dti-3495	381	22	chronic	chronic	ADJ
dti-3495	381	23	inflammation	inflammation	NOUN
dti-3495	381	24	and	and	CCONJ
dti-3495	381	25	the	the	DET
dti-3495	381	26	improvement	improvement	NOUN
dti-3495	381	27	of	of	ADP
dti-3495	381	28	insulin	insulin	NOUN
dti-3495	381	29	resistance	resistance	NOUN
dti-3495	381	30	in	in	ADP
dti-3495	381	31	type	type	NOUN
dti-3495	381	32	2	2	NUM
dti-3495	381	33	diabetes	diabetes	NOUN
dti-3495	381	34	.	.	PUNCT
dti-3495	382	1	multi	multi	ADJ
dti-3495	382	2	-	-	ADJ
dti-3495	382	3	target	target	NOUN
dti-3495	382	4	therapy	therapy	NOUN
dti-3495	382	5	in	in	ADP
dti-3495	382	6	this	this	DET
dti-3495	382	7	case	case	NOUN
dti-3495	382	8	entails	entail	VERB
dti-3495	382	9	the	the	DET
dti-3495	382	10	identification	identification	NOUN
dti-3495	382	11	of	of	ADP
dti-3495	382	12	a	a	DET
dti-3495	382	13	number	number	NOUN
dti-3495	382	14	of	of	ADP
dti-3495	382	15	pathways	pathway	NOUN
dti-3495	382	16	or	or	CCONJ
dti-3495	382	17	proteins	protein	NOUN
dti-3495	382	18	that	that	PRON
dti-3495	382	19	are	be	AUX
dti-3495	382	20	related	relate	VERB
dti-3495	382	21	to	to	ADP
dti-3495	382	22	the	the	DET
dti-3495	382	23	disease	disease	NOUN
dti-3495	382	24	and	and	CCONJ
dti-3495	382	25	treating	treat	VERB
dti-3495	382	26	all	all	PRON
dti-3495	382	27	of	of	ADP
dti-3495	382	28	them	they	PRON
dti-3495	382	29	at	at	ADP
dti-3495	382	30	once	once	ADV
dti-3495	382	31	.	.	PUNCT
dti-3495	383	1	this	this	PRON
dti-3495	383	2	is	be	AUX
dti-3495	383	3	thought	think	VERB
dti-3495	383	4	to	to	PART
dti-3495	383	5	be	be	AUX
dti-3495	383	6	a	a	DET
dti-3495	383	7	better	well	ADJ
dti-3495	383	8	approach	approach	NOUN
dti-3495	383	9	to	to	ADP
dti-3495	383	10	treating	treat	VERB
dti-3495	383	11	various	various	ADJ
dti-3495	383	12	intricate	intricate	ADJ
dti-3495	383	13	conditions	condition	NOUN
dti-3495	383	14	like	like	ADP
dti-3495	383	15	type	type	NOUN
dti-3495	383	16	2	2	NUM
dti-3495	383	17	diabetes	diabetes	NOUN
dti-3495	383	18	by	by	ADP
dti-3495	383	19	combating	combat	VERB
dti-3495	383	20	various	various	ADJ
dti-3495	383	21	causes	cause	NOUN
dti-3495	383	22	.	.	PUNCT
dti-3495	384	1	in	in	ADP
dti-3495	384	2	the	the	DET
dti-3495	384	3	future	future	NOUN
dti-3495	384	4	,	,	PUNCT
dti-3495	384	5	the	the	DET
dti-3495	384	6	findings	finding	NOUN
dti-3495	384	7	of	of	ADP
dti-3495	384	8	this	this	DET
dti-3495	384	9	study	study	NOUN
dti-3495	384	10	can	can	AUX
dti-3495	384	11	provide	provide	VERB
dti-3495	384	12	a	a	DET
dti-3495	384	13	good	good	ADJ
dti-3495	384	14	foundation	foundation	NOUN
dti-3495	384	15	for	for	ADP
dti-3495	384	16	subsequent	subsequent	ADJ
dti-3495	384	17	research	research	NOUN
dti-3495	384	18	into	into	ADP
dti-3495	384	19	the	the	DET
dti-3495	384	20	medical	medical	ADJ
dti-3495	384	21	value	value	NOUN
dti-3495	384	22	of	of	ADP
dti-3495	384	23	compounds	compound	NOUN
dti-3495	384	24	of	of	ADP
dti-3495	384	25	extracts	extract	NOUN
dti-3495	384	26	from	from	ADP
dti-3495	384	27	v.	v.	ADP
dti-3495	384	28	unguiculata	unguiculata	PROPN
dti-3495	384	29	.	.	PUNCT
dti-3495	385	1	in	in	ADP
dti-3495	385	2	vivo	vivo	ADJ
dti-3495	385	3	studies	study	NOUN
dti-3495	385	4	can	can	AUX
dti-3495	385	5	also	also	ADV
dti-3495	385	6	be	be	AUX
dti-3495	385	7	undertaken	undertake	VERB
dti-3495	385	8	to	to	PART
dti-3495	385	9	validate	validate	VERB
dti-3495	385	10	the	the	DET
dti-3495	385	11	findings	finding	NOUN
dti-3495	385	12	made	make	VERB
dti-3495	385	13	in	in	ADP
dti-3495	385	14	silico	silico	NOUN
dti-3495	385	15	and	and	CCONJ
dti-3495	385	16	further	far	ADV
dti-3495	385	17	examine	examine	VERB
dti-3495	385	18	the	the	DET
dti-3495	385	19	pk	pk	PROPN
dti-3495	385	20	/	/	SYM
dti-3495	385	21	pd	pd	PROPN
dti-3495	385	22	characteristics	characteristic	NOUN
dti-3495	385	23	of	of	ADP
dti-3495	385	24	these	these	DET
dti-3495	385	25	compounds	compound	NOUN
dti-3495	385	26	.	.	PUNCT
dti-3495	386	1	we	we	PRON
dti-3495	386	2	also	also	ADV
dti-3495	386	3	supposed	suppose	VERB
dti-3495	386	4	that	that	SCONJ
dti-3495	386	5	the	the	DET
dti-3495	386	6	other	other	ADJ
dti-3495	386	7	target	target	NOUN
dti-3495	386	8	proteins	protein	NOUN
dti-3495	386	9	may	may	AUX
dti-3495	386	10	be	be	AUX
dti-3495	386	11	required	require	VERB
dti-3495	386	12	for	for	ADP
dti-3495	386	13	further	further	ADJ
dti-3495	386	14	research	research	NOUN
dti-3495	386	15	,	,	PUNCT
dti-3495	386	16	and	and	CCONJ
dti-3495	386	17	they	they	PRON
dti-3495	386	18	may	may	AUX
dti-3495	386	19	discover	discover	VERB
dti-3495	386	20	the	the	DET
dti-3495	386	21	new	new	ADJ
dti-3495	386	22	multi	multi	ADJ
dti-3495	386	23	-	-	ADJ
dti-3495	386	24	target	target	ADJ
dti-3495	386	25	drug	drug	NOUN
dti-3495	386	26	for	for	ADP
dti-3495	386	27	the	the	DET
dti-3495	386	28	better	well	ADJ
dti-3495	386	29	treatment	treatment	NOUN
dti-3495	386	30	of	of	ADP
dti-3495	386	31	t2	t2	NOUN
dti-3495	386	32	dm	dm	NOUN
dti-3495	386	33	,	,	PUNCT
dti-3495	386	34	especially	especially	ADV
dti-3495	386	35	gsk3b	gsk3b	PROPN
dti-3495	386	36	,	,	PUNCT
dti-3495	386	37	ptgs2	ptgs2	PROPN
dti-3495	386	38	,	,	PUNCT
dti-3495	386	39	and	and	CCONJ
dti-3495	386	40	tlr4	tlr4	NOUN
dti-3495	386	41	.	.	PUNCT
dti-3495	387	1	further	further	ADJ
dti-3495	387	2	insights	insight	NOUN
dti-3495	387	3	on	on	ADP
dti-3495	387	4	how	how	SCONJ
dti-3495	387	5	these	these	DET
dti-3495	387	6	compounds	compound	NOUN
dti-3495	387	7	collectively	collectively	ADV
dti-3495	387	8	function	function	VERB
dti-3495	387	9	might	might	AUX
dti-3495	387	10	be	be	AUX
dti-3495	387	11	helpful	helpful	ADJ
dti-3495	387	12	in	in	ADP
dti-3495	387	13	designing	design	VERB
dti-3495	387	14	improved	improved	ADJ
dti-3495	387	15	combination	combination	NOUN
dti-3495	387	16	therapies	therapy	NOUN
dti-3495	387	17	,	,	PUNCT
dti-3495	387	18	which	which	PRON
dti-3495	387	19	could	could	AUX
dti-3495	387	20	be	be	AUX
dti-3495	387	21	beneficial	beneficial	ADJ
dti-3495	387	22	in	in	ADP
dti-3495	387	23	patients	patient	NOUN
dti-3495	387	24	.	.	PUNCT
dti-3495	388	1	hence	hence	ADV
dti-3495	388	2	,	,	PUNCT
dti-3495	388	3	this	this	DET
dti-3495	388	4	work	work	NOUN
dti-3495	388	5	not	not	PART
dti-3495	388	6	only	only	ADV
dti-3495	388	7	opens	open	VERB
dti-3495	388	8	more	more	ADJ
dti-3495	388	9	evidence	evidence	NOUN
dti-3495	388	10	about	about	ADP
dti-3495	388	11	network	network	NOUN
dti-3495	388	12	pharmacology	pharmacology	NOUN
dti-3495	388	13	as	as	ADP
dti-3495	388	14	a	a	DET
dti-3495	388	15	strategy	strategy	NOUN
dti-3495	388	16	for	for	ADP
dti-3495	388	17	searching	search	VERB
dti-3495	388	18	the	the	DET
dti-3495	388	19	targets	target	NOUN
dti-3495	388	20	and	and	CCONJ
dti-3495	388	21	new	new	ADJ
dti-3495	388	22	drugs	drug	NOUN
dti-3495	388	23	’	'	PUNCT
dti-3495	388	24	designs	design	NOUN
dti-3495	388	25	but	but	CCONJ
dti-3495	388	26	also	also	ADV
dti-3495	388	27	shows	show	VERB
dti-3495	388	28	the	the	DET
dti-3495	388	29	application	application	NOUN
dti-3495	388	30	of	of	ADP
dti-3495	388	31	plant	plant	NOUN
dti-3495	388	32	extracts	extract	NOUN
dti-3495	388	33	as	as	ADP
dti-3495	388	34	a	a	DET
dti-3495	388	35	treatment	treatment	NOUN
dti-3495	388	36	for	for	ADP
dti-3495	388	37	chronic	chronic	ADJ
dti-3495	388	38	diseases	disease	NOUN
dti-3495	388	39	.	.	PUNCT
dti-3495	389	1	conclusion	conclusion	NOUN
dti-3495	389	2	in	in	ADP
dti-3495	389	3	the	the	DET
dti-3495	389	4	present	present	ADJ
dti-3495	389	5	study	study	NOUN
dti-3495	389	6	,	,	PUNCT
dti-3495	389	7	the	the	DET
dti-3495	389	8	v.	v.	PROPN
dti-3495	389	9	unguiculata	unguiculata	PROPN
dti-3495	389	10	was	be	AUX
dti-3495	389	11	evaluated	evaluate	VERB
dti-3495	389	12	for	for	ADP
dti-3495	389	13	anti	anti	ADJ
dti-3495	389	14	-	-	ADJ
dti-3495	389	15	diabetic	diabetic	ADJ
dti-3495	389	16	potential	potential	NOUN
dti-3495	389	17	using	use	VERB
dti-3495	389	18	in	in	ADP
dti-3495	389	19	vitro	vitro	X
dti-3495	389	20	,	,	PUNCT
dti-3495	389	21	network	network	NOUN
dti-3495	389	22	pharmacology	pharmacology	NOUN
dti-3495	389	23	,	,	PUNCT
dti-3495	389	24	and	and	CCONJ
dti-3495	389	25	computational	computational	ADJ
dti-3495	389	26	approaches	approach	NOUN
dti-3495	389	27	.	.	PUNCT
dti-3495	390	1	the	the	DET
dti-3495	390	2	results	result	NOUN
dti-3495	390	3	of	of	ADP
dti-3495	390	4	the	the	DET
dti-3495	390	5	in	in	ADV
dti-3495	390	6	vitro	vitro	X
dti-3495	390	7	analysis	analysis	NOUN
dti-3495	390	8	using	use	VERB
dti-3495	390	9	v.	v.	ADP
dti-3495	390	10	unguiculata	unguiculata	ADJ
dti-3495	390	11	phytochemicals	phytochemical	NOUN
dti-3495	390	12	showed	show	VERB
dti-3495	390	13	significant	significant	ADJ
dti-3495	390	14	activity	activity	NOUN
dti-3495	390	15	against	against	ADP
dti-3495	390	16	the	the	DET
dti-3495	390	17	diabetes	diabetes	NOUN
dti-3495	390	18	targets	target	NOUN
dti-3495	390	19	such	such	ADJ
dti-3495	390	20	as	as	ADP
dti-3495	390	21	α	α	NOUN
dti-3495	390	22	-	-	NOUN
dti-3495	390	23	amylase	amylase	NOUN
dti-3495	390	24	,	,	PUNCT
dti-3495	390	25	α	α	NOUN
dti-3495	390	26	-	-	NOUN
dti-3495	390	27	glucosidase	glucosidase	NOUN
dti-3495	390	28	,	,	PUNCT
dti-3495	390	29	and	and	CCONJ
dti-3495	390	30	aldose	aldose	PRON
dti-3495	390	31	reductase	reductase	NOUN
dti-3495	390	32	enzymes	enzyme	NOUN
dti-3495	390	33	concerned	concern	VERB
dti-3495	390	34	with	with	ADP
dti-3495	390	35	glucose	glucose	NOUN
dti-3495	390	36	metabolism	metabolism	NOUN
dti-3495	390	37	.	.	PUNCT
dti-3495	391	1	furthermore	furthermore	ADV
dti-3495	391	2	,	,	PUNCT
dti-3495	391	3	the	the	DET
dti-3495	391	4	network	network	NOUN
dti-3495	391	5	pharmacology	pharmacology	NOUN
dti-3495	391	6	studies	study	NOUN
dti-3495	391	7	showed	show	VERB
dti-3495	391	8	88	88	NUM
dti-3495	391	9	shared	shared	ADJ
dti-3495	391	10	target	target	NOUN
dti-3495	391	11	genes	gene	NOUN
dti-3495	391	12	associated	associate	VERB
dti-3495	391	13	with	with	ADP
dti-3495	391	14	t2	t2	PROPN
dti-3495	391	15	dm	dm	PROPN
dti-3495	391	16	,	,	PUNCT
dti-3495	391	17	and	and	CCONJ
dti-3495	391	18	the	the	DET
dti-3495	391	19	possible	possible	ADJ
dti-3495	391	20	drug	drug	NOUN
dti-3495	391	21	targets	target	NOUN
dti-3495	391	22	,	,	PUNCT
dti-3495	391	23	i.e.	i.e.	X
dti-3495	391	24	,	,	PUNCT
dti-3495	391	25	gsk3b	gsk3b	PROPN
dti-3495	391	26	,	,	PUNCT
dti-3495	391	27	ptgs2	ptgs2	PROPN
dti-3495	391	28	,	,	PUNCT
dti-3495	391	29	and	and	CCONJ
dti-3495	391	30	tlr4	tlr4	NOUN
dti-3495	391	31	were	be	AUX
dti-3495	391	32	deemed	deem	VERB
dti-3495	391	33	as	as	ADP
dti-3495	391	34	hub	hub	NOUN
dti-3495	391	35	genes	gene	NOUN
dti-3495	391	36	in	in	ADP
dti-3495	391	37	the	the	DET
dti-3495	391	38	ppi	ppi	NOUN
dti-3495	391	39	network	network	NOUN
dti-3495	391	40	.	.	PUNCT
dti-3495	392	1	the	the	DET
dti-3495	392	2	in	in	ADP
dti-3495	392	3	vitro	vitro	X
dti-3495	392	4	and	and	CCONJ
dti-3495	392	5	network	network	NOUN
dti-3495	392	6	pharmacology	pharmacology	NOUN
dti-3495	392	7	studies	study	NOUN
dti-3495	392	8	were	be	AUX
dti-3495	392	9	followed	follow	VERB
dti-3495	392	10	by	by	ADP
dti-3495	392	11	the	the	DET
dti-3495	392	12	computational	computational	ADJ
dti-3495	392	13	studies	study	NOUN
dti-3495	392	14	using	use	VERB
dti-3495	392	15	virtual	virtual	ADJ
dti-3495	392	16	screening	screening	NOUN
dti-3495	392	17	,	,	PUNCT
dti-3495	392	18	md	md	PROPN
dti-3495	392	19	simulation	simulation	NOUN
dti-3495	392	20	,	,	PUNCT
dti-3495	392	21	and	and	CCONJ
dti-3495	392	22	binding	bind	VERB
dti-3495	392	23	free	free	ADJ
dti-3495	392	24	energies	energy	NOUN
dti-3495	392	25	calculations	calculation	NOUN
dti-3495	392	26	.	.	PUNCT
dti-3495	393	1	the	the	DET
dti-3495	393	2	virtual	virtual	ADJ
dti-3495	393	3	screening	screening	NOUN
dti-3495	393	4	showed	show	VERB
dti-3495	393	5	the	the	DET
dti-3495	393	6	phytochemicals	phytochemical	NOUN
dti-3495	393	7	,	,	PUNCT
dti-3495	393	8	i.e.	i.e.	X
dti-3495	393	9	,	,	PUNCT
dti-3495	393	10	quercetin	quercetin	NOUN
dti-3495	393	11	,	,	PUNCT
dti-3495	393	12	luteolin	luteolin	PROPN
dti-3495	393	13	,	,	PUNCT
dti-3495	393	14	and	and	CCONJ
dti-3495	393	15	stigmasterol	stigmasterol	NOUN
dti-3495	393	16	,	,	PUNCT
dti-3495	393	17	with	with	ADP
dti-3495	393	18	the	the	DET
dti-3495	393	19	highest	high	ADJ
dti-3495	393	20	binding	bind	VERB
dti-3495	393	21	energy	energy	NOUN
dti-3495	393	22	against	against	ADP
dti-3495	393	23	the	the	DET
dti-3495	393	24	diabetes	diabetes	NOUN
dti-3495	393	25	targets	target	NOUN
dti-3495	393	26	.	.	PUNCT
dti-3495	394	1	the	the	DET
dti-3495	394	2	md	md	PROPN
dti-3495	394	3	simulation	simulation	PROPN
dti-3495	394	4	studies	study	NOUN
dti-3495	394	5	were	be	AUX
dti-3495	394	6	conducted	conduct	VERB
dti-3495	394	7	following	follow	VERB
dti-3495	394	8	the	the	DET
dti-3495	394	9	virtual	virtual	ADJ
dti-3495	394	10	screening	screening	NOUN
dti-3495	394	11	to	to	PART
dti-3495	394	12	assess	assess	VERB
dti-3495	394	13	the	the	DET
dti-3495	394	14	dynamic	dynamic	ADJ
dti-3495	394	15	stability	stability	NOUN
dti-3495	394	16	,	,	PUNCT
dti-3495	394	17	and	and	CCONJ
dti-3495	394	18	the	the	DET
dti-3495	394	19	results	result	NOUN
dti-3495	394	20	showed	show	VERB
dti-3495	394	21	that	that	SCONJ
dti-3495	394	22	the	the	DET
dti-3495	394	23	complexes	complex	NOUN
dti-3495	394	24	remain	remain	VERB
dti-3495	394	25	stable	stable	ADJ
dti-3495	394	26	.	.	PUNCT
dti-3495	395	1	the	the	DET
dti-3495	395	2	binding	bind	VERB
dti-3495	395	3	free	free	ADJ
dti-3495	395	4	energy	energy	NOUN
dti-3495	395	5	studies	study	NOUN
dti-3495	395	6	using	use	VERB
dti-3495	395	7	mm	mm	NOUN
dti-3495	395	8	-	-	PUNCT
dti-3495	395	9	pbsa	pbsa	NOUN
dti-3495	395	10	,	,	PUNCT
dti-3495	395	11	and	and	CCONJ
dti-3495	395	12	mm	mm	NOUN
dti-3495	395	13	-	-	PUNCT
dti-3495	395	14	gbsa	gbsa	PROPN
dti-3495	395	15	exhibited	exhibit	VERB
dti-3495	395	16	negative	negative	ADJ
dti-3495	395	17	and	and	CCONJ
dti-3495	395	18	favorable	favorable	ADJ
dti-3495	395	19	binding	binding	ADJ
dti-3495	395	20	energies	energy	NOUN
dti-3495	395	21	,	,	PUNCT
dti-3495	395	22	hence	hence	ADV
dti-3495	395	23	indicating	indicate	VERB
dti-3495	395	24	the	the	DET
dti-3495	395	25	stability	stability	NOUN
dti-3495	395	26	of	of	ADP
dti-3495	395	27	the	the	DET
dti-3495	395	28	complexes	complex	NOUN
dti-3495	395	29	.	.	PUNCT
dti-3495	396	1	in	in	ADP
dti-3495	396	2	conclusion	conclusion	NOUN
dti-3495	396	3	,	,	PUNCT
dti-3495	396	4	the	the	DET
dti-3495	396	5	study	study	NOUN
dti-3495	396	6	showed	show	VERB
dti-3495	396	7	that	that	SCONJ
dti-3495	396	8	v.	v.	ADP
dti-3495	396	9	unguiculata	unguiculata	ADJ
dti-3495	396	10	phytochemicals	phytochemical	NOUN
dti-3495	396	11	exhibited	exhibit	VERB
dti-3495	396	12	significant	significant	ADJ
dti-3495	396	13	activity	activity	NOUN
dti-3495	396	14	against	against	ADP
dti-3495	396	15	the	the	DET
dti-3495	396	16	diabetes	diabetes	NOUN
dti-3495	396	17	targets	target	NOUN
dti-3495	396	18	using	use	VERB
dti-3495	396	19	in	in	ADP
dti-3495	396	20	vitro	vitro	X
dti-3495	396	21	,	,	PUNCT
dti-3495	396	22	network	network	NOUN
dti-3495	396	23	pharmacology	pharmacology	NOUN
dti-3495	396	24	,	,	PUNCT
dti-3495	396	25	and	and	CCONJ
dti-3495	396	26	comprehensive	comprehensive	ADJ
dti-3495	396	27	computational	computational	ADJ
dti-3495	396	28	approaches	approach	NOUN
dti-3495	396	29	;	;	PUNCT
dti-3495	396	30	however	however	ADV
dti-3495	396	31	,	,	PUNCT
dti-3495	396	32	to	to	PART
dti-3495	396	33	employ	employ	VERB
dti-3495	396	34	the	the	DET
dti-3495	396	35	v.	v.	PROPN
dti-3495	396	36	unguiculata	unguiculata	ADJ
dti-3495	396	37	phytochemicals	phytochemical	NOUN
dti-3495	396	38	clinically	clinically	ADV
dti-3495	396	39	additional	additional	ADJ
dti-3495	396	40	studies	study	NOUN
dti-3495	396	41	such	such	ADJ
dti-3495	396	42	as	as	ADP
dti-3495	396	43	comprehensive	comprehensive	ADJ
dti-3495	396	44	in	in	ADP
dti-3495	396	45	-	-	PUNCT
dti-3495	396	46	vivo	vivo	NOUN
dti-3495	396	47	approaches	approach	NOUN
dti-3495	396	48	will	will	AUX
dti-3495	396	49	be	be	AUX
dti-3495	396	50	required	require	VERB
dti-3495	396	51	.	.	PUNCT
dti-3495	397	1	limitations	limitation	NOUN
dti-3495	397	2	of	of	ADP
dti-3495	397	3	the	the	DET
dti-3495	397	4	study	study	NOUN
dti-3495	397	5	the	the	DET
dti-3495	397	6	limitations	limitation	NOUN
dti-3495	397	7	of	of	ADP
dti-3495	397	8	this	this	DET
dti-3495	397	9	study	study	NOUN
dti-3495	397	10	include	include	VERB
dti-3495	397	11	the	the	DET
dti-3495	397	12	lack	lack	NOUN
dti-3495	397	13	of	of	ADP
dti-3495	397	14	in	in	ADP
dti-3495	397	15	vivo	vivo	ADJ
dti-3495	397	16	validation	validation	NOUN
dti-3495	397	17	despite	despite	SCONJ
dti-3495	397	18	the	the	DET
dti-3495	397	19	fact	fact	NOUN
dti-3495	397	20	that	that	SCONJ
dti-3495	397	21	the	the	DET
dti-3495	397	22	present	present	ADJ
dti-3495	397	23	study	study	NOUN
dti-3495	397	24	includes	include	VERB
dti-3495	397	25	in	in	ADP
dti-3495	397	26	vitro	vitro	X
dti-3495	397	27	analysis	analysis	NOUN
dti-3495	397	28	,	,	PUNCT
dti-3495	397	29	network	network	NOUN
dti-3495	397	30	pharmacology	pharmacology	NOUN
dti-3495	397	31	approaches	approach	NOUN
dti-3495	397	32	,	,	PUNCT
dti-3495	397	33	and	and	CCONJ
dti-3495	397	34	comprehensive	comprehensive	ADJ
dti-3495	397	35	computational	computational	ADJ
dti-3495	397	36	approaches	approach	NOUN
dti-3495	397	37	.	.	PUNCT
dti-3495	398	1	in	in	ADP
dti-3495	398	2	order	order	NOUN
dti-3495	398	3	to	to	PART
dti-3495	398	4	validate	validate	VERB
dti-3495	398	5	the	the	DET
dti-3495	398	6	results	result	NOUN
dti-3495	398	7	of	of	ADP
dti-3495	398	8	the	the	DET
dti-3495	398	9	study	study	NOUN
dti-3495	398	10	,	,	PUNCT
dti-3495	398	11	the	the	DET
dti-3495	398	12	in	in	ADP
dti-3495	398	13	vivo	vivo	ADJ
dti-3495	398	14	studies	study	NOUN
dti-3495	398	15	,	,	PUNCT
dti-3495	398	16	including	include	VERB
dti-3495	398	17	pharmacokinetics	pharmacokinetic	NOUN
dti-3495	398	18	,	,	PUNCT
dti-3495	398	19	pharmacodynamics	pharmacodynamic	NOUN
dti-3495	398	20	,	,	PUNCT
dti-3495	398	21	and	and	CCONJ
dti-3495	398	22	toxicities	toxicity	NOUN
dti-3495	398	23	associated	associate	VERB
dti-3495	398	24	with	with	ADP
dti-3495	398	25	the	the	DET
dti-3495	398	26	top	top	ADJ
dti-3495	398	27	hits	hit	NOUN
dti-3495	398	28	,	,	PUNCT
dti-3495	398	29	should	should	AUX
dti-3495	398	30	be	be	AUX
dti-3495	398	31	conducted	conduct	VERB
dti-3495	398	32	.	.	PUNCT
dti-3495	399	1	furthermore	furthermore	ADV
dti-3495	399	2	,	,	PUNCT
dti-3495	399	3	the	the	DET
dti-3495	399	4	study	study	NOUN
dti-3495	399	5	mainly	mainly	ADV
dti-3495	399	6	focused	focus	VERB
dti-3495	399	7	on	on	ADP
dti-3495	399	8	identifying	identify	VERB
dti-3495	399	9	the	the	DET
dti-3495	399	10	molecular	molecular	ADJ
dti-3495	399	11	targets	target	NOUN
dti-3495	399	12	and	and	CCONJ
dti-3495	399	13	binding	bind	VERB
dti-3495	399	14	affinities	affinity	NOUN
dti-3495	399	15	;	;	PUNCT
dti-3495	399	16	the	the	DET
dti-3495	399	17	stability	stability	NOUN
dti-3495	399	18	of	of	ADP
dti-3495	399	19	the	the	DET
dti-3495	399	20	compounds	compound	NOUN
dti-3495	399	21	in	in	ADP
dti-3495	399	22	the	the	DET
dti-3495	399	23	in	in	ADP
dti-3495	399	24	vivo	vivo	NOUN
dti-3495	399	25	system	system	NOUN
dti-3495	399	26	,	,	PUNCT
dti-3495	399	27	such	such	ADJ
dti-3495	399	28	as	as	ADP
dti-3495	399	29	metabolism	metabolism	NOUN
dti-3495	399	30	,	,	PUNCT
dti-3495	399	31	protein	protein	NOUN
dti-3495	399	32	binding	binding	NOUN
dti-3495	399	33	,	,	PUNCT
dti-3495	399	34	and	and	CCONJ
dti-3495	399	35	solubility	solubility	NOUN
dti-3495	399	36	,	,	PUNCT
dti-3495	399	37	was	be	AUX
dti-3495	399	38	not	not	PART
dti-3495	399	39	studied	study	VERB
dti-3495	399	40	.	.	PUNCT
dti-3495	400	1	similarly	similarly	ADV
dti-3495	400	2	,	,	PUNCT
dti-3495	400	3	the	the	DET
dti-3495	400	4	computational	computational	ADJ
dti-3495	400	5	studies	study	NOUN
dti-3495	400	6	offer	offer	VERB
dti-3495	400	7	key	key	ADJ
dti-3495	400	8	insight	insight	NOUN
dti-3495	400	9	into	into	ADP
dti-3495	400	10	the	the	DET
dti-3495	400	11	ligand	ligand	NOUN
dti-3495	400	12	’s	’s	PART
dti-3495	400	13	interaction	interaction	NOUN
dti-3495	400	14	with	with	ADP
dti-3495	400	15	the	the	DET
dti-3495	400	16	target	target	NOUN
dti-3495	400	17	protein	protein	NOUN
dti-3495	400	18	;	;	PUNCT
dti-3495	400	19	however	however	ADV
dti-3495	400	20	,	,	PUNCT
dti-3495	400	21	the	the	DET
dti-3495	400	22	computational	computational	ADJ
dti-3495	400	23	studies	study	NOUN
dti-3495	400	24	are	be	AUX
dti-3495	400	25	influenced	influence	VERB
dti-3495	400	26	by	by	ADP
dti-3495	400	27	various	various	ADJ
dti-3495	400	28	factors	factor	NOUN
dti-3495	400	29	such	such	ADJ
dti-3495	400	30	as	as	ADP
dti-3495	400	31	the	the	DET
dti-3495	400	32	type	type	NOUN
dti-3495	400	33	of	of	ADP
dti-3495	400	34	force	force	NOUN
dti-3495	400	35	field	field	NOUN
dti-3495	400	36	used	use	VERB
dti-3495	400	37	and	and	CCONJ
dti-3495	400	38	the	the	DET
dti-3495	400	39	input	input	NOUN
dti-3495	400	40	of	of	ADP
dti-3495	400	41	the	the	DET
dti-3495	400	42	structure	structure	NOUN
dti-3495	400	43	provided	provide	VERB
dti-3495	400	44	.	.	PUNCT
dti-3495	401	1	furthermore	furthermore	ADV
dti-3495	401	2	,	,	PUNCT
dti-3495	401	3	the	the	DET
dti-3495	401	4	study	study	NOUN
dti-3495	401	5	also	also	ADV
dti-3495	401	6	lacks	lack	VERB
dti-3495	401	7	in	in	ADP
dti-3495	401	8	vitro	vitro	X
dti-3495	401	9	and	and	CCONJ
dti-3495	401	10	in	in	ADP
dti-3495	401	11	vivo	vivo	ADJ
dti-3495	401	12	studies	study	NOUN
dti-3495	401	13	to	to	PART
dti-3495	401	14	assess	assess	VERB
dti-3495	401	15	the	the	DET
dti-3495	401	16	off	off	ADP
dti-3495	401	17	-	-	PUNCT
dti-3495	401	18	target	target	NOUN
dti-3495	401	19	effect	effect	NOUN
dti-3495	401	20	and	and	CCONJ
dti-3495	401	21	to	to	PART
dti-3495	401	22	explore	explore	VERB
dti-3495	401	23	the	the	DET
dti-3495	401	24	safety	safety	NOUN
dti-3495	401	25	profile	profile	NOUN
dti-3495	401	26	of	of	ADP
dti-3495	401	27	the	the	DET
dti-3495	401	28	compounds	compound	NOUN
dti-3495	401	29	;	;	PUNCT
dti-3495	401	30	thus	thus	ADV
dti-3495	401	31	,	,	PUNCT
dti-3495	401	32	to	to	PART
dti-3495	401	33	establish	establish	VERB
dti-3495	401	34	the	the	DET
dti-3495	401	35	specificity	specificity	NOUN
dti-3495	401	36	,	,	PUNCT
dti-3495	401	37	selectivity	selectivity	NOUN
dti-3495	401	38	,	,	PUNCT
dti-3495	401	39	and	and	CCONJ
dti-3495	401	40	safety	safety	NOUN
dti-3495	401	41	of	of	ADP
dti-3495	401	42	the	the	DET
dti-3495	401	43	studied	study	VERB
dti-3495	401	44	compounds	compound	NOUN
dti-3495	401	45	,	,	PUNCT
dti-3495	401	46	comprehensive	comprehensive	ADJ
dti-3495	401	47	in	in	ADP
dti-3495	401	48	vitro	vitro	X
dti-3495	401	49	and	and	CCONJ
dti-3495	401	50	in	in	ADP
dti-3495	401	51	vivo	vivo	ADJ
dti-3495	401	52	studies	study	NOUN
dti-3495	401	53	will	will	AUX
dti-3495	401	54	be	be	AUX
dti-3495	401	55	required	require	VERB
dti-3495	401	56	.	.	PUNCT
dti-3495	402	1	authors	author	NOUN
dti-3495	402	2	contributors	contributor	NOUN
dti-3495	402	3	hs	hs	PROPN
dti-3495	402	4	:	:	PUNCT
dti-3495	402	5	data	data	NOUN
dti-3495	402	6	curation	curation	NOUN
dti-3495	402	7	,	,	PUNCT
dti-3495	402	8	writing	write	VERB
dti-3495	402	9	–	–	PUNCT
dti-3495	402	10	original	original	ADJ
dti-3495	402	11	draft	draft	NOUN
dti-3495	402	12	;	;	PUNCT
dti-3495	402	13	fatima	fatima	PROPN
dti-3495	402	14	noor	noor	PROPN
dti-3495	402	15	:	:	PUNCT
dti-3495	402	16	data	datum	NOUN
dti-3495	402	17	curation	curation	NOUN
dti-3495	402	18	,	,	PUNCT
dti-3495	402	19	writing	write	VERB
dti-3495	402	20	–	–	PUNCT
dti-3495	402	21	original	original	ADJ
dti-3495	402	22	draft	draft	NOUN
dti-3495	402	23	;	;	PUNCT
dti-3495	402	24	sms	sm	NOUN
dti-3495	402	25	:	:	PUNCT
dti-3495	402	26	data	datum	NOUN
dti-3495	402	27	analysis	analysis	NOUN
dti-3495	402	28	,	,	PUNCT
dti-3495	402	29	writing	writing	NOUN
dti-3495	402	30	–	–	PUNCT
dti-3495	402	31	original	original	ADJ
dti-3495	402	32	draft	draft	NOUN
dti-3495	402	33	;	;	PUNCT
dti-3495	402	34	jsao	jsao	NOUN
dti-3495	402	35	:	:	PUNCT
dti-3495	402	36	data	data	NOUN
dti-3495	402	37	curation	curation	NOUN
dti-3495	402	38	,	,	PUNCT
dti-3495	402	39	writing	write	VERB
dti-3495	402	40	–	–	PUNCT
dti-3495	402	41	original	original	ADJ
dti-3495	402	42	draft	draft	NOUN
dti-3495	402	43	;	;	PUNCT
dti-3495	402	44	auk	auk	NOUN
dti-3495	402	45	:	:	PUNCT
dti-3495	402	46	data	data	NOUN
dti-3495	402	47	curation	curation	NOUN
dti-3495	402	48	,	,	PUNCT
dti-3495	402	49	writing	write	VERB
dti-3495	402	50	–	–	PUNCT
dti-3495	402	51	original	original	ADJ
dti-3495	402	52	draft	draft	NOUN
dti-3495	402	53	,	,	PUNCT
dti-3495	402	54	md	md	PROPN
dti-3495	402	55	:	:	PUNCT
dti-3495	402	56	data	datum	NOUN
dti-3495	402	57	curation	curation	NOUN
dti-3495	402	58	,	,	PUNCT
dti-3495	402	59	writing	write	VERB
dti-3495	402	60	–	–	PUNCT
dti-3495	402	61	final	final	ADJ
dti-3495	402	62	draft	draft	NOUN
dti-3495	402	63	;	;	PUNCT
dti-3495	402	64	hk	hk	NOUN
dti-3495	402	65	:	:	PUNCT
dti-3495	402	66	designing	designing	NOUN
dti-3495	402	67	,	,	PUNCT
dti-3495	402	68	supervision	supervision	NOUN
dti-3495	402	69	,	,	PUNCT
dti-3495	402	70	writing	write	VERB
dti-3495	402	71	–	–	PUNCT
dti-3495	402	72	final	final	ADJ
dti-3495	402	73	draft	draft	NOUN
dti-3495	402	74	acknowledgment	acknowledgment	NOUN
dti-3495	402	75	the	the	DET
dti-3495	402	76	authors	author	NOUN
dti-3495	402	77	are	be	AUX
dti-3495	402	78	thankful	thankful	ADJ
dti-3495	402	79	to	to	ADP
dti-3495	402	80	hec	hec	PROPN
dti-3495	402	81	pakistan	pakistan	PROPN
dti-3495	402	82	for	for	ADP
dti-3495	402	83	financial	financial	ADJ
dti-3495	402	84	support	support	NOUN
dti-3495	402	85	under	under	ADP
dti-3495	402	86	project	project	NOUN
dti-3495	402	87	no	no	NOUN
dti-3495	402	88	:	:	PUNCT
dti-3495	402	89	(	(	PUNCT
dti-3495	402	90	ref	ref	VERB
dti-3495	402	91	no	no	INTJ
dti-3495	402	92	.	.	NOUN
dti-3495	402	93	20	20	NUM
dti-3495	402	94	-	-	SYM
dti-3495	402	95	16097	16097	NUM
dti-3495	402	96	/	/	SYM
dti-3495	402	97	nrpu	nrpu	NOUN
dti-3495	402	98	/	/	SYM
dti-3495	402	99	r&d/	r&d/	NOUN
dti-3495	402	100	hec/2021	hec/2021	VERB
dti-3495	402	101	2021	2021	NUM
dti-3495	402	102	)	)	PUNCT
dti-3495	402	103	.	.	PUNCT
dti-3495	403	1	the	the	DET
dti-3495	403	2	authors	author	NOUN
dti-3495	403	3	extend	extend	VERB
dti-3495	403	4	their	their	PRON
dti-3495	403	5	appreciation	appreciation	NOUN
dti-3495	403	6	to	to	ADP
dti-3495	403	7	the	the	DET
dti-3495	403	8	princess	princess	PROPN
dti-3495	403	9	nourah	nourah	PROPN
dti-3495	403	10	bint	bint	PROPN
dti-3495	403	11	abdulrahman	abdulrahman	PROPN
dti-3495	403	12	university	university	PROPN
dti-3495	403	13	researchers	researcher	NOUN
dti-3495	403	14	supporting	support	VERB
dti-3495	403	15	project	project	NOUN
dti-3495	403	16	number	number	NOUN
dti-3495	403	17	(	(	PUNCT
dti-3495	403	18	pnursp2025r13	pnursp2025r13	NOUN
dti-3495	403	19	)	)	PUNCT
dti-3495	403	20	,	,	PUNCT
dti-3495	403	21	princess	princess	PROPN
dti-3495	403	22	nourah	nourah	PROPN
dti-3495	403	23	bint	bint	PROPN
dti-3495	403	24	abdulrahman	abdulrahman	PROPN
dti-3495	403	25	university	university	PROPN
dti-3495	403	26	,	,	PUNCT
dti-3495	403	27	saudi	saudi	PROPN
dti-3495	403	28	arabia	arabia	PROPN
dti-3495	403	29	.	.	PUNCT
dti-3495	404	1	data	datum	NOUN
dti-3495	404	2	availability	availability	NOUN
dti-3495	404	3	statement	statement	NOUN
dti-3495	404	4	the	the	DET
dti-3495	404	5	data	datum	NOUN
dti-3495	404	6	that	that	PRON
dti-3495	404	7	support	support	VERB
dti-3495	404	8	the	the	DET
dti-3495	404	9	findings	finding	NOUN
dti-3495	404	10	of	of	ADP
dti-3495	404	11	the	the	DET
dti-3495	404	12	present	present	ADJ
dti-3495	404	13	study	study	NOUN
dti-3495	404	14	are	be	AUX
dti-3495	404	15	available	available	ADJ
dti-3495	404	16	from	from	ADP
dti-3495	404	17	the	the	DET
dti-3495	404	18	corresponding	correspond	VERB
dti-3495	404	19	authors	author	NOUN
dti-3495	404	20	upon	upon	SCONJ
dti-3495	404	21	reasonable	reasonable	ADJ
dti-3495	404	22	request	request	NOUN
dti-3495	404	23	.	.	PUNCT
dti-3495	405	1	disclosures	disclosure	NOUN
dti-3495	405	2	conflict	conflict	NOUN
dti-3495	405	3	of	of	ADP
dti-3495	405	4	interest	interest	NOUN
dti-3495	405	5	:	:	PUNCT
dti-3495	405	6	the	the	DET
dti-3495	405	7	authors	author	NOUN
dti-3495	405	8	of	of	ADP
dti-3495	405	9	this	this	DET
dti-3495	405	10	article	article	NOUN
dti-3495	405	11	have	have	VERB
dti-3495	405	12	a	a	DET
dti-3495	405	13	conflict	conflict	NOUN
dti-3495	405	14	of	of	ADP
dti-3495	405	15	interest	interest	NOUN
dti-3495	405	16	financial	financial	ADJ
dti-3495	405	17	support	support	NOUN
dti-3495	405	18	:	:	PUNCT
dti-3495	405	19	this	this	DET
dti-3495	405	20	research	research	NOUN
dti-3495	405	21	received	receive	VERB
dti-3495	405	22	no	no	DET
dti-3495	405	23	specific	specific	ADJ
dti-3495	405	24	grant	grant	NOUN
dti-3495	405	25	from	from	ADP
dti-3495	405	26	any	any	DET
dti-3495	405	27	funding	funding	NOUN
dti-3495	405	28	agency	agency	NOUN
dti-3495	405	29	in	in	ADP
dti-3495	405	30	the	the	DET
dti-3495	405	31	public	public	ADJ
dti-3495	405	32	,	,	PUNCT
dti-3495	405	33	commercial	commercial	ADJ
dti-3495	405	34	,	,	PUNCT
dti-3495	405	35	or	or	CCONJ
dti-3495	405	36	not	not	PART
dti-3495	405	37	-	-	PUNCT
dti-3495	405	38	for	for	ADP
dti-3495	405	39	-	-	PUNCT
dti-3495	405	40	profit	profit	NOUN
dti-3495	405	41	sectors	sector	NOUN
dti-3495	405	42	references	reference	NOUN
dti-3495	405	43	1	1	NUM
dti-3495	405	44	.	.	PUNCT
dti-3495	406	1	noor	noor	PROPN
dti-3495	406	2	f	f	PROPN
dti-3495	406	3	,	,	PUNCT
dti-3495	406	4	rehman	rehman	NOUN
dti-3495	406	5	a	a	PRON
dti-3495	406	6	,	,	PUNCT
dti-3495	406	7	ashfaq	ashfaq	PROPN
dti-3495	406	8	ua	ua	PROPN
dti-3495	406	9	,	,	PUNCT
dti-3495	406	10	et	et	PROPN
dti-3495	406	11	al	al	PROPN
dti-3495	406	12	.	.	PUNCT
dti-3495	406	13	integrating	integrate	VERB
dti-3495	406	14	network	network	NOUN
dti-3495	406	15	pharmacology	pharmacology	NOUN
dti-3495	406	16	and	and	CCONJ
dti-3495	406	17	molecular	molecular	ADJ
dti-3495	406	18	docking	docking	NOUN
dti-3495	406	19	approaches	approach	NOUN
dti-3495	406	20	to	to	ADP
dti-3495	406	21	decipher	decipher	NOUN
dti-3495	406	22	the	the	DET
dti-3495	406	23	multi	multi	ADJ
dti-3495	406	24	-	-	ADJ
dti-3495	406	25	target	target	ADJ
dti-3495	406	26	pharmacological	pharmacological	ADJ
dti-3495	406	27	mechanism	mechanism	NOUN
dti-3495	406	28	of	of	ADP
dti-3495	406	29	abrus	abrus	PROPN
dti-3495	406	30	precatorius	precatorius	PROPN
dti-3495	406	31	l.	l.	NOUN
dti-3495	406	32	acting	act	VERB
dti-3495	406	33	on	on	ADP
dti-3495	406	34	diabetes	diabetes	NOUN
dti-3495	406	35	.	.	PUNCT
dti-3495	407	1	pharmaceuticals	pharmaceutical	NOUN
dti-3495	407	2	(	(	PUNCT
dti-3495	407	3	basel	basel	PROPN
dti-3495	407	4	)	)	PUNCT
dti-3495	407	5	.	.	PUNCT
dti-3495	408	1	2022;15(4):414	2022;15(4):414	NUM
dti-3495	408	2	.	.	PUNCT
dti-3495	409	1	crossref	crossref	PROPN
dti-3495	409	2	pubmed	pubmed	PROPN
dti-3495	409	3	https://doi.org/10.3390/ph15040414	https://doi.org/10.3390/ph15040414	PROPN
dti-3495	410	1	https://pubmed.ncbi.nlm.nih.gov/35455411	https://pubmed.ncbi.nlm.nih.gov/35455411	PROPN
dti-3495	410	2	sardar	sardar	PROPN
dti-3495	410	3	et	et	PROPN
dti-3495	410	4	al	al	PROPN
dti-3495	410	5	drug	drug	PROPN
dti-3495	410	6	target	target	NOUN
dti-3495	410	7	insights	insight	NOUN
dti-3495	410	8	2025	2025	NUM
dti-3495	410	9	;	;	PUNCT
dti-3495	410	10	19	19	NUM
dti-3495	410	11	:	:	SYM
dti-3495	410	12	89	89	NUM
dti-3495	410	13	©	©	PROPN
dti-3495	410	14	2025	2025	NUM
dti-3495	410	15	the	the	DET
dti-3495	410	16	authors	author	NOUN
dti-3495	410	17	.	.	PUNCT
dti-3495	411	1	published	publish	VERB
dti-3495	411	2	by	by	ADP
dti-3495	411	3	aboutscience	aboutscience	NOUN
dti-3495	411	4	www.aboutscience.eu	www.aboutscience.eu	NOUN
dti-3495	411	5	2	2	NUM
dti-3495	411	6	.	.	PUNCT
dti-3495	411	7	ruze	ruze	PROPN
dti-3495	411	8	r	r	PROPN
dti-3495	411	9	,	,	PUNCT
dti-3495	411	10	liu	liu	PROPN
dti-3495	411	11	t	t	PROPN
dti-3495	411	12	,	,	PUNCT
dti-3495	411	13	zou	zou	PROPN
dti-3495	411	14	x	x	PROPN
dti-3495	411	15	,	,	PUNCT
dti-3495	411	16	et	et	PROPN
dti-3495	411	17	al	al	PROPN
dti-3495	411	18	.	.	PROPN
dti-3495	411	19	obesity	obesity	NOUN
dti-3495	411	20	and	and	CCONJ
dti-3495	411	21	type	type	NOUN
dti-3495	411	22	2	2	NUM
dti-3495	411	23	diabetes	diabetes	NOUN
dti-3495	411	24	mellitus	mellitus	NOUN
dti-3495	411	25	:	:	PUNCT
dti-3495	411	26	connections	connection	NOUN
dti-3495	411	27	in	in	ADP
dti-3495	411	28	epidemiology	epidemiology	NOUN
dti-3495	411	29	,	,	PUNCT
dti-3495	411	30	pathogenesis	pathogenesis	NOUN
dti-3495	411	31	,	,	PUNCT
dti-3495	411	32	and	and	CCONJ
dti-3495	411	33	treatments	treatment	NOUN
dti-3495	411	34	.	.	PUNCT
dti-3495	412	1	front	front	ADJ
dti-3495	412	2	endocrinol	endocrinol	NOUN
dti-3495	412	3	(	(	PUNCT
dti-3495	412	4	lausanne	lausanne	PROPN
dti-3495	412	5	)	)	PUNCT
dti-3495	412	6	.	.	PUNCT
dti-3495	413	1	2023;14:1161521	2023;14:1161521	X
dti-3495	413	2	.	.	PUNCT
dti-3495	413	3	crossref	crossref	PROPN
dti-3495	413	4	pubmed	pubmed	PROPN
dti-3495	413	5	3	3	PROPN
dti-3495	413	6	.	.	PUNCT
dti-3495	414	1	mishra	mishra	PROPN
dti-3495	414	2	s	s	PROPN
dti-3495	414	3	,	,	PUNCT
dti-3495	414	4	kumar	kumar	PROPN
dti-3495	414	5	s	s	PROPN
dti-3495	414	6	,	,	PUNCT
dti-3495	414	7	darokar	darokar	PROPN
dti-3495	414	8	mp	mp	PROPN
dti-3495	414	9	,	,	PUNCT
dti-3495	414	10	et	et	PROPN
dti-3495	414	11	al	al	PROPN
dti-3495	414	12	.	.	PROPN
dti-3495	414	13	novel	novel	PROPN
dti-3495	414	14	bioactive	bioactive	PROPN
dti-3495	414	15	compound	compound	NOUN
dti-3495	414	16	from	from	ADP
dti-3495	414	17	the	the	DET
dti-3495	414	18	bark	bark	NOUN
dti-3495	414	19	of	of	ADP
dti-3495	414	20	putranjiva	putranjiva	PROPN
dti-3495	414	21	roxburghii	roxburghii	PROPN
dti-3495	414	22	wall	wall	PROPN
dti-3495	414	23	.	.	PUNCT
dti-3495	415	1	nat	nat	PROPN
dti-3495	415	2	prod	prod	PROPN
dti-3495	415	3	res	re	NOUN
dti-3495	415	4	.	.	PUNCT
dti-3495	416	1	2021;35(10):1738	2021;35(10):1738	NUM
dti-3495	416	2	-	-	PROPN
dti-3495	416	3	1740	1740	NUM
dti-3495	416	4	.	.	PUNCT
dti-3495	417	1	crossref	crossref	PROPN
dti-3495	417	2	pubmed	pubmed	PROPN
dti-3495	417	3	4	4	PROPN
dti-3495	417	4	.	.	PUNCT
dti-3495	418	1	ahmad	ahmad	PROPN
dti-3495	418	2	e	e	PROPN
dti-3495	418	3	,	,	PUNCT
dti-3495	418	4	lim	lim	PROPN
dti-3495	418	5	s	s	PROPN
dti-3495	418	6	,	,	PUNCT
dti-3495	418	7	lamptey	lamptey	ADJ
dti-3495	418	8	r	r	NOUN
dti-3495	418	9	,	,	PUNCT
dti-3495	418	10	et	et	PROPN
dti-3495	418	11	al	al	PROPN
dti-3495	418	12	.	.	PROPN
dti-3495	418	13	type	type	NOUN
dti-3495	418	14	2	2	NUM
dti-3495	418	15	diabetes	diabetes	NOUN
dti-3495	418	16	.	.	PUNCT
dti-3495	419	1	lancet	lancet	PROPN
dti-3495	419	2	.	.	PUNCT
dti-3495	420	1	2022;400(10365):1803	2022;400(10365):1803	NUM
dti-3495	420	2	-	-	SYM
dti-3495	420	3	1820	1820	NUM
dti-3495	420	4	.	.	PUNCT
dti-3495	421	1	crossref	crossref	PROPN
dti-3495	421	2	pubmed	pubmed	PROPN
dti-3495	421	3	5	5	PROPN
dti-3495	421	4	.	.	PUNCT
dti-3495	422	1	galicia	galicia	PROPN
dti-3495	422	2	-	-	PUNCT
dti-3495	422	3	garcia	garcia	PROPN
dti-3495	422	4	u	u	PROPN
dti-3495	422	5	,	,	PUNCT
dti-3495	422	6	benito	benito	PROPN
dti-3495	422	7	-	-	PROPN
dti-3495	422	8	vicente	vicente	PROPN
dti-3495	422	9	a	a	PRON
dti-3495	422	10	,	,	PUNCT
dti-3495	422	11	jebari	jebari	PROPN
dti-3495	422	12	s	s	PART
dti-3495	422	13	,	,	PUNCT
dti-3495	422	14	et	et	PROPN
dti-3495	422	15	al	al	PROPN
dti-3495	422	16	.	.	PROPN
dti-3495	422	17	pathophysiology	pathophysiology	NOUN
dti-3495	422	18	of	of	ADP
dti-3495	422	19	type	type	NOUN
dti-3495	422	20	2	2	NUM
dti-3495	422	21	diabetes	diabetes	NOUN
dti-3495	422	22	mellitus	mellitus	NOUN
dti-3495	422	23	.	.	PUNCT
dti-3495	423	1	int	int	PROPN
dti-3495	423	2	j	j	PROPN
dti-3495	423	3	mol	mol	ADP
dti-3495	423	4	sci	sci	PROPN
dti-3495	423	5	.	.	PUNCT
dti-3495	424	1	2020;21(17):6275	2020;21(17):6275	NUM
dti-3495	424	2	.	.	PUNCT
dti-3495	424	3	crossref	crossref	PROPN
dti-3495	424	4	pubmed	pubmed	PROPN
dti-3495	424	5	6	6	NUM
dti-3495	424	6	.	.	PUNCT
dti-3495	425	1	demir	demir	PROPN
dti-3495	425	2	s	s	PROPN
dti-3495	425	3	,	,	PUNCT
dti-3495	425	4	nawroth	nawroth	PRON
dti-3495	425	5	pp	pp	PROPN
dti-3495	425	6	,	,	PUNCT
dti-3495	425	7	herzig	herzig	PROPN
dti-3495	425	8	s	s	PROPN
dti-3495	425	9	,	,	PUNCT
dti-3495	425	10	et	et	PROPN
dti-3495	425	11	al	al	PROPN
dti-3495	425	12	.	.	PUNCT
dti-3495	426	1	emerging	emerge	VERB
dti-3495	426	2	targets	target	NOUN
dti-3495	426	3	in	in	ADP
dti-3495	426	4	type	type	NOUN
dti-3495	426	5	2	2	NUM
dti-3495	426	6	diabetes	diabetes	NOUN
dti-3495	426	7	and	and	CCONJ
dti-3495	426	8	diabetic	diabetic	ADJ
dti-3495	426	9	complications	complication	NOUN
dti-3495	426	10	.	.	PUNCT
dti-3495	427	1	adv	adv	PROPN
dti-3495	427	2	sci	sci	PROPN
dti-3495	427	3	(	(	PUNCT
dti-3495	427	4	weinh	weinh	PROPN
dti-3495	427	5	)	)	PUNCT
dti-3495	427	6	.	.	PUNCT
dti-3495	428	1	2021;8(18):e2100275	2021;8(18):e2100275	NUM
dti-3495	428	2	.	.	PUNCT
dti-3495	429	1	crossref	crossref	PROPN
dti-3495	429	2	pubmed	pubmed	PROPN
dti-3495	429	3	7	7	PROPN
dti-3495	429	4	.	.	PUNCT
dti-3495	430	1	reed	reed	PROPN
dti-3495	430	2	j	j	PROPN
dti-3495	430	3	,	,	PUNCT
dti-3495	430	4	bain	bain	PROPN
dti-3495	430	5	s	s	PROPN
dti-3495	430	6	,	,	PUNCT
dti-3495	430	7	kanamarlapudi	kanamarlapudi	PROPN
dti-3495	430	8	v.	v.	ADP
dti-3495	430	9	a	a	DET
dti-3495	430	10	review	review	NOUN
dti-3495	430	11	of	of	ADP
dti-3495	430	12	current	current	ADJ
dti-3495	430	13	trends	trend	NOUN
dti-3495	430	14	with	with	ADP
dti-3495	430	15	type	type	NOUN
dti-3495	430	16	2	2	NUM
dti-3495	430	17	diabetes	diabetes	NOUN
dti-3495	430	18	epidemiology	epidemiology	NOUN
dti-3495	430	19	,	,	PUNCT
dti-3495	430	20	aetiology	aetiology	NOUN
dti-3495	430	21	,	,	PUNCT
dti-3495	430	22	pathogenesis	pathogenesis	NOUN
dti-3495	430	23	,	,	PUNCT
dti-3495	430	24	treatments	treatment	NOUN
dti-3495	430	25	and	and	CCONJ
dti-3495	430	26	future	future	ADJ
dti-3495	430	27	perspectives	perspective	NOUN
dti-3495	430	28	.	.	PUNCT
dti-3495	431	1	diabetes	diabetes	VERB
dti-3495	431	2	metab	metab	NOUN
dti-3495	431	3	syndr	syndr	NOUN
dti-3495	431	4	obes	obe	NOUN
dti-3495	431	5	.	.	PUNCT
dti-3495	432	1	2021;14:3567	2021;14:3567	NUM
dti-3495	432	2	-	-	SYM
dti-3495	432	3	3602	3602	NUM
dti-3495	432	4	.	.	PUNCT
dti-3495	433	1	crossref	crossref	PROPN
dti-3495	433	2	pubmed	pubmed	PROPN
dti-3495	433	3	8	8	PROPN
dti-3495	433	4	.	.	PUNCT
dti-3495	434	1	noor	noor	PROPN
dti-3495	434	2	f	f	PROPN
dti-3495	434	3	,	,	PUNCT
dti-3495	434	4	tahir	tahir	PROPN
dti-3495	434	5	ul	ul	PROPN
dti-3495	434	6	qamar	qamar	PROPN
dti-3495	434	7	m	m	PROPN
dti-3495	434	8	,	,	PUNCT
dti-3495	434	9	ashfaq	ashfaq	PROPN
dti-3495	434	10	ua	ua	PROPN
dti-3495	434	11	,	,	PUNCT
dti-3495	434	12	et	et	PROPN
dti-3495	434	13	al	al	PROPN
dti-3495	434	14	.	.	PROPN
dti-3495	434	15	network	network	NOUN
dti-3495	434	16	pharmacology	pharmacology	NOUN
dti-3495	434	17	approach	approach	NOUN
dti-3495	434	18	for	for	ADP
dti-3495	434	19	medicinal	medicinal	ADJ
dti-3495	434	20	plants	plant	NOUN
dti-3495	434	21	:	:	PUNCT
dti-3495	434	22	review	review	NOUN
dti-3495	434	23	and	and	CCONJ
dti-3495	434	24	assessment	assessment	NOUN
dti-3495	434	25	.	.	PUNCT
dti-3495	435	1	pharmaceuticals	pharmaceutical	NOUN
dti-3495	435	2	(	(	PUNCT
dti-3495	435	3	basel	basel	PROPN
dti-3495	435	4	)	)	PUNCT
dti-3495	435	5	.	.	PUNCT
dti-3495	436	1	2022;15(5):572	2022;15(5):572	NUM
dti-3495	436	2	.	.	PUNCT
dti-3495	437	1	crossref	crossref	PROPN
dti-3495	437	2	pubmed	pubmed	PROPN
dti-3495	437	3	9	9	PROPN
dti-3495	437	4	.	.	PUNCT
dti-3495	438	1	noor	noor	PROPN
dti-3495	438	2	f	f	PROPN
dti-3495	438	3	,	,	PUNCT
dti-3495	438	4	asif	asif	PROPN
dti-3495	438	5	m	m	PROPN
dti-3495	438	6	,	,	PUNCT
dti-3495	438	7	ashfaq	ashfaq	PROPN
dti-3495	438	8	ua	ua	PROPN
dti-3495	438	9	,	,	PUNCT
dti-3495	438	10	et	et	PROPN
dti-3495	438	11	al	al	PROPN
dti-3495	438	12	.	.	PROPN
dti-3495	438	13	machine	machine	NOUN
dti-3495	438	14	learning	learn	VERB
dti-3495	438	15	for	for	ADP
dti-3495	438	16	synergistic	synergistic	ADJ
dti-3495	438	17	network	network	NOUN
dti-3495	438	18	pharmacology	pharmacology	NOUN
dti-3495	438	19	:	:	PUNCT
dti-3495	438	20	a	a	DET
dti-3495	438	21	comprehensive	comprehensive	ADJ
dti-3495	438	22	overview	overview	NOUN
dti-3495	438	23	.	.	PUNCT
dti-3495	439	1	brief	brief	ADJ
dti-3495	439	2	bioinform	bioinform	NOUN
dti-3495	439	3	.	.	PUNCT
dti-3495	440	1	2023;24(3):120	2023;24(3):120	NUM
dti-3495	440	2	.	.	PUNCT
dti-3495	441	1	crossref	crossref	PROPN
dti-3495	441	2	pubmed	pubmed	PROPN
dti-3495	441	3	10	10	PROPN
dti-3495	441	4	.	.	PUNCT
dti-3495	442	1	boukar	boukar	PROPN
dti-3495	442	2	o	o	PROPN
dti-3495	442	3	,	,	PUNCT
dti-3495	442	4	et	et	PROPN
dti-3495	442	5	al	al	PROPN
dti-3495	442	6	.	.	PROPN
dti-3495	442	7	,	,	PUNCT
dti-3495	442	8	cowpea	cowpea	PROPN
dti-3495	442	9	(	(	PUNCT
dti-3495	442	10	vigna	vigna	PROPN
dti-3495	442	11	unguiculata	unguiculata	PROPN
dti-3495	442	12	):	):	PUNCT
dti-3495	442	13	genetics	genetic	NOUN
dti-3495	442	14	,	,	PUNCT
dti-3495	442	15	genomics	genomic	NOUN
dti-3495	442	16	and	and	CCONJ
dti-3495	442	17	breeding	breeding	NOUN
dti-3495	442	18	.	.	PUNCT
dti-3495	443	1	2019;138(4):415	2019;138(4):415	NUM
dti-3495	443	2	-	-	SYM
dti-3495	443	3	424	424	NUM
dti-3495	443	4	.	.	PUNCT
dti-3495	444	1	crossref	crossref	PROPN
dti-3495	444	2	11	11	NUM
dti-3495	444	3	.	.	PUNCT
dti-3495	445	1	olopade	olopade	PROPN
dti-3495	445	2	ob	ob	PROPN
dti-3495	445	3	,	,	PUNCT
dti-3495	445	4	et	et	PROPN
dti-3495	445	5	al	al	PROPN
dti-3495	445	6	.	.	PROPN
dti-3495	445	7	,	,	PUNCT
dti-3495	446	1	glycemic	glycemic	ADJ
dti-3495	446	2	responses	response	NOUN
dti-3495	446	3	of	of	ADP
dti-3495	446	4	local	local	ADJ
dti-3495	446	5	beans	bean	NOUN
dti-3495	446	6	(	(	PUNCT
dti-3495	446	7	vigna	vigna	PROPN
dti-3495	446	8	unguiculata	unguiculata	PROPN
dti-3495	446	9	(	(	PUNCT
dti-3495	446	10	linn	linn	PROPN
dti-3495	446	11	walp	walp	PROPN
dti-3495	446	12	)	)	PUNCT
dti-3495	446	13	varieties	variety	NOUN
dti-3495	446	14	)	)	PUNCT
dti-3495	446	15	in	in	ADP
dti-3495	446	16	persons	person	NOUN
dti-3495	446	17	with	with	ADP
dti-3495	446	18	type	type	NOUN
dti-3495	446	19	2	2	NUM
dti-3495	446	20	diabetes	diabetes	NOUN
dti-3495	446	21	mellitus	mellitus	NOUN
dti-3495	446	22	and	and	CCONJ
dti-3495	446	23	healthy	healthy	ADJ
dti-3495	446	24	controls	control	NOUN
dti-3495	446	25	-	-	PUNCT
dti-3495	446	26	an	an	DET
dti-3495	446	27	experimental	experimental	ADJ
dti-3495	446	28	study	study	NOUN
dti-3495	446	29	.	.	PUNCT
dti-3495	447	1	2020;17(4):100	2020;17(4):100	NUM
dti-3495	447	2	-	-	PUNCT
dti-3495	447	3	107	107	NUM
dti-3495	447	4	.	.	PUNCT
dti-3495	448	1	crossref	crossref	PROPN
dti-3495	448	2	12	12	NUM
dti-3495	448	3	.	.	PUNCT
dti-3495	449	1	ashraduzzaman	ashraduzzaman	PROPN
dti-3495	449	2	m	m	PROPN
dti-3495	449	3	,	,	PUNCT
dti-3495	449	4	et	et	PROPN
dti-3495	449	5	al	al	PROPN
dti-3495	449	6	.	.	PROPN
dti-3495	449	7	,	,	PUNCT
dti-3495	449	8	vigna	vigna	PROPN
dti-3495	449	9	unguiculata	unguiculata	PROPN
dti-3495	449	10	linn	linn	PROPN
dti-3495	449	11	.	.	PUNCT
dti-3495	450	1	walp	walp	PROPN
dti-3495	450	2	.	.	PUNCT
dti-3495	451	1	seed	seed	NOUN
dti-3495	451	2	oil	oil	NOUN
dti-3495	451	3	exhibiting	exhibit	VERB
dti-3495	451	4	anti	anti	ADJ
dti-3495	451	5	-	-	ADJ
dti-3495	451	6	diabetic	diabetic	ADJ
dti-3495	451	7	effects	effect	NOUN
dti-3495	451	8	in	in	ADP
dti-3495	451	9	alloxan	alloxan	NOUN
dti-3495	451	10	induced	induce	VERB
dti-3495	451	11	diabetic	diabetic	ADJ
dti-3495	451	12	rats	rat	NOUN
dti-3495	451	13	.	.	PUNCT
dti-3495	452	1	2011;9(1):13	2011;9(1):13	NUM
dti-3495	452	2	-	-	SYM
dti-3495	452	3	23	23	NUM
dti-3495	452	4	.	.	PUNCT
dti-3495	453	1	13	13	NUM
dti-3495	453	2	.	.	PUNCT
dti-3495	454	1	wang	wang	PROPN
dti-3495	454	2	l	l	PROPN
dti-3495	454	3	,	,	PUNCT
dti-3495	454	4	li	li	PROPN
dti-3495	454	5	j	j	PROPN
dti-3495	454	6	,	,	PUNCT
dti-3495	454	7	di	di	PROPN
dti-3495	454	8	lj	lj	PROPN
dti-3495	454	9	.	.	PUNCT
dti-3495	454	10	glycogen	glycogen	NOUN
dti-3495	454	11	synthesis	synthesis	NOUN
dti-3495	454	12	and	and	CCONJ
dti-3495	454	13	beyond	beyond	ADP
dti-3495	454	14	,	,	PUNCT
dti-3495	454	15	a	a	DET
dti-3495	454	16	comprehensive	comprehensive	ADJ
dti-3495	454	17	review	review	NOUN
dti-3495	454	18	of	of	ADP
dti-3495	454	19	gsk3	gsk3	NOUN
dti-3495	454	20	as	as	ADP
dti-3495	454	21	a	a	DET
dti-3495	454	22	key	key	ADJ
dti-3495	454	23	regulator	regulator	NOUN
dti-3495	454	24	of	of	ADP
dti-3495	454	25	metabolic	metabolic	NOUN
dti-3495	454	26	pathways	pathway	NOUN
dti-3495	454	27	and	and	CCONJ
dti-3495	454	28	a	a	DET
dti-3495	454	29	therapeutic	therapeutic	ADJ
dti-3495	454	30	target	target	NOUN
dti-3495	454	31	for	for	ADP
dti-3495	454	32	treating	treat	VERB
dti-3495	454	33	metabolic	metabolic	NOUN
dti-3495	454	34	diseases	disease	NOUN
dti-3495	454	35	.	.	PUNCT
dti-3495	455	1	med	med	PROPN
dti-3495	455	2	res	re	NOUN
dti-3495	455	3	rev	rev	X
dti-3495	455	4	.	.	PUNCT
dti-3495	456	1	2022;42(2):946	2022;42(2):946	PROPN
dti-3495	456	2	-	-	SYM
dti-3495	456	3	982	982	NUM
dti-3495	456	4	.	.	PUNCT
dti-3495	457	1	crossref	crossref	PROPN
dti-3495	457	2	pubmed	pubmed	PROPN
dti-3495	457	3	14	14	PROPN
dti-3495	457	4	.	.	PUNCT
dti-3495	458	1	yehualashet	yehualashet	NOUN
dti-3495	458	2	as	as	ADP
dti-3495	458	3	.	.	PUNCT
dti-3495	458	4	toll	toll	NOUN
dti-3495	458	5	-	-	PUNCT
dti-3495	458	6	like	like	ADJ
dti-3495	458	7	receptors	receptor	NOUN
dti-3495	458	8	as	as	ADP
dti-3495	458	9	a	a	DET
dti-3495	458	10	potential	potential	ADJ
dti-3495	458	11	drug	drug	NOUN
dti-3495	458	12	target	target	NOUN
dti-3495	458	13	for	for	ADP
dti-3495	458	14	diabetes	diabetes	NOUN
dti-3495	458	15	mellitus	mellitus	NOUN
dti-3495	458	16	and	and	CCONJ
dti-3495	458	17	diabetes	diabetes	NOUN
dti-3495	458	18	-	-	PUNCT
dti-3495	458	19	associated	associate	VERB
dti-3495	458	20	complications	complication	NOUN
dti-3495	458	21	.	.	PUNCT
dti-3495	459	1	diabetes	diabetes	NOUN
dti-3495	459	2	metab	metab	NOUN
dti-3495	459	3	syndr	syndr	NOUN
dti-3495	459	4	obes	obe	NOUN
dti-3495	459	5	.	.	PUNCT
dti-3495	460	1	2020;13:4763	2020;13:4763	NUM
dti-3495	460	2	-	-	SYM
dti-3495	460	3	4777	4777	NUM
dti-3495	460	4	.	.	PUNCT
dti-3495	461	1	crossref	crossref	PROPN
dti-3495	461	2	pubmed	pubmed	PROPN
dti-3495	461	3	15	15	PROPN
dti-3495	461	4	.	.	PUNCT
dti-3495	462	1	martín	martín	NOUN
dti-3495	462	2	-	-	PUNCT
dti-3495	462	3	vázquez	vázquez	NOUN
dti-3495	462	4	e	e	NOUN
dti-3495	462	5	,	,	PUNCT
dti-3495	462	6	cobo	cobo	PROPN
dti-3495	462	7	-	-	PROPN
dti-3495	462	8	vuilleumier	vuilleumier	PROPN
dti-3495	462	9	n	n	CCONJ
dti-3495	462	10	,	,	PUNCT
dti-3495	462	11	lópez	lópez	NOUN
dti-3495	462	12	-	-	PUNCT
dti-3495	462	13	noriega	noriega	PROPN
dti-3495	462	14	l	l	PROPN
dti-3495	462	15	,	,	PUNCT
dti-3495	462	16	et	et	PROPN
dti-3495	462	17	al	al	PROPN
dti-3495	462	18	.	.	PUNCT
dti-3495	463	1	the	the	DET
dti-3495	463	2	ptgs2	ptgs2	PROPN
dti-3495	463	3	/	/	SYM
dti-3495	463	4	cox2	cox2	NOUN
dti-3495	463	5	-	-	PUNCT
dti-3495	463	6	pge2	pge2	NOUN
dti-3495	463	7	signaling	signal	VERB
dti-3495	463	8	cascade	cascade	NOUN
dti-3495	463	9	in	in	ADP
dti-3495	463	10	inflammation	inflammation	NOUN
dti-3495	463	11	:	:	PUNCT
dti-3495	463	12	pro	pro	ADJ
dti-3495	463	13	or	or	CCONJ
dti-3495	463	14	anti	anti	ADJ
dti-3495	463	15	?	?	NOUN
dti-3495	463	16	a	a	DET
dti-3495	463	17	case	case	NOUN
dti-3495	463	18	study	study	NOUN
dti-3495	463	19	with	with	ADP
dti-3495	463	20	type	type	NOUN
dti-3495	463	21	1	1	NUM
dti-3495	463	22	diabetes	diabetes	NOUN
dti-3495	463	23	mellitus	mellitus	NOUN
dti-3495	463	24	.	.	PUNCT
dti-3495	464	1	int	int	PROPN
dti-3495	464	2	j	j	PROPN
dti-3495	464	3	biol	biol	PROPN
dti-3495	464	4	sci	sci	PROPN
dti-3495	464	5	.	.	PUNCT
dti-3495	465	1	2023;19(13):4157	2023;19(13):4157	NUM
dti-3495	465	2	-	-	NOUN
dti-3495	465	3	4165	4165	NUM
dti-3495	465	4	.	.	PUNCT
dti-3495	466	1	crossref	crossref	PROPN
dti-3495	466	2	pubmed	pubmed	PROPN
dti-3495	466	3	16	16	PROPN
dti-3495	466	4	.	.	PUNCT
dti-3495	467	1	cucak	cucak	PROPN
dti-3495	467	2	h	h	PROPN
dti-3495	467	3	,	,	PUNCT
dti-3495	467	4	mayer	mayer	PROPN
dti-3495	467	5	c	c	PROPN
dti-3495	467	6	,	,	PUNCT
dti-3495	467	7	tonnesen	tonnesen	VERB
dti-3495	467	8	m	m	PROPN
dti-3495	467	9	,	,	PUNCT
dti-3495	467	10	et	et	PROPN
dti-3495	467	11	al	al	PROPN
dti-3495	467	12	.	.	PUNCT
dti-3495	467	13	macrophage	macrophage	ADJ
dti-3495	467	14	contact	contact	NOUN
dti-3495	467	15	dependent	dependent	ADJ
dti-3495	467	16	and	and	CCONJ
dti-3495	467	17	independent	independent	ADJ
dti-3495	467	18	tlr4	tlr4	NOUN
dti-3495	467	19	mechanisms	mechanism	NOUN
dti-3495	467	20	induce	induce	VERB
dti-3495	467	21	β	β	NOUN
dti-3495	467	22	-	-	NOUN
dti-3495	467	23	cell	cell	NOUN
dti-3495	467	24	dysfunction	dysfunction	NOUN
dti-3495	467	25	and	and	CCONJ
dti-3495	467	26	apoptosis	apoptosis	NOUN
dti-3495	467	27	in	in	ADP
dti-3495	467	28	a	a	DET
dti-3495	467	29	mouse	mouse	NOUN
dti-3495	467	30	model	model	NOUN
dti-3495	467	31	of	of	ADP
dti-3495	467	32	type	type	NOUN
dti-3495	467	33	2	2	NUM
dti-3495	467	34	diabetes	diabetes	NOUN
dti-3495	467	35	.	.	PUNCT
dti-3495	468	1	plos	plos	PROPN
dti-3495	468	2	one	one	NUM
dti-3495	468	3	.	.	PUNCT
dti-3495	469	1	2014;9(3):e90685	2014;9(3):e90685	NUM
dti-3495	469	2	.	.	PUNCT
dti-3495	470	1	crossref	crossref	PROPN
dti-3495	470	2	pubmed	pubmed	PROPN
dti-3495	470	3	17	17	NUM
dti-3495	470	4	.	.	PUNCT
dti-3495	471	1	wadhwa	wadhwa	PROPN
dti-3495	471	2	p	p	NOUN
dti-3495	471	3	,	,	PUNCT
dti-3495	471	4	jain	jain	PROPN
dti-3495	471	5	p	p	X
dti-3495	471	6	,	,	PUNCT
dti-3495	471	7	jadhav	jadhav	PROPN
dti-3495	471	8	hr	hr	PROPN
dti-3495	471	9	.	.	PUNCT
dti-3495	472	1	glycogen	glycogen	NOUN
dti-3495	472	2	synthase	synthase	NOUN
dti-3495	472	3	kinase	kinase	PROPN
dti-3495	472	4	3	3	NUM
dti-3495	472	5	(	(	PUNCT
dti-3495	472	6	gsk3	gsk3	PROPN
dti-3495	472	7	):	):	PUNCT
dti-3495	472	8	its	its	PRON
dti-3495	472	9	role	role	NOUN
dti-3495	472	10	and	and	CCONJ
dti-3495	472	11	inhibitors	inhibitor	NOUN
dti-3495	472	12	.	.	PUNCT
dti-3495	473	1	curr	curr	PROPN
dti-3495	473	2	top	top	ADJ
dti-3495	473	3	med	med	ADJ
dti-3495	473	4	chem	chem	NOUN
dti-3495	473	5	.	.	PUNCT
dti-3495	474	1	2020;20(17):15221534	2020;20(17):15221534	X
dti-3495	474	2	.	.	PUNCT
dti-3495	474	3	crossref	crossref	PROPN
dti-3495	474	4	pubmed	pubmed	PROPN
dti-3495	474	5	18	18	NUM
dti-3495	474	6	.	.	PUNCT
dti-3495	475	1	mishra	mishra	PROPN
dti-3495	475	2	s	s	PROPN
dti-3495	475	3	,	,	PUNCT
dti-3495	475	4	kumar	kumar	PROPN
dti-3495	475	5	s	s	PROPN
dti-3495	475	6	,	,	PUNCT
dti-3495	475	7	ramdas	ramdas	PROPN
dti-3495	475	8	,	,	PUNCT
dti-3495	475	9	et	et	PROPN
dti-3495	475	10	al	al	PROPN
dti-3495	475	11	.	.	PROPN
dti-3495	475	12	quebrachitol	quebrachitol	NOUN
dti-3495	475	13	from	from	ADP
dti-3495	475	14	putranjiva	putranjiva	PROPN
dti-3495	475	15	roxburghii	roxburghii	PROPN
dti-3495	475	16	wall	wall	PROPN
dti-3495	475	17	.	.	PUNCT
dti-3495	476	1	(	(	PUNCT
dti-3495	476	2	putranjivaceae	putranjivaceae	PROPN
dti-3495	476	3	)	)	PUNCT
dti-3495	476	4	a	a	DET
dti-3495	476	5	potent	potent	ADJ
dti-3495	476	6	antimalarial	antimalarial	NOUN
dti-3495	476	7	:	:	PUNCT
dti-3495	476	8	preclinical	preclinical	ADJ
dti-3495	476	9	efficacy	efficacy	NOUN
dti-3495	476	10	and	and	CCONJ
dti-3495	476	11	its	its	PRON
dti-3495	476	12	interaction	interaction	NOUN
dti-3495	476	13	with	with	ADP
dti-3495	476	14	pfldh	pfldh	NOUN
dti-3495	476	15	.	.	PUNCT
dti-3495	477	1	parasitol	parasitol	NOUN
dti-3495	477	2	int	int	NOUN
dti-3495	477	3	.	.	PUNCT
dti-3495	478	1	2023;92:102675	2023;92:102675	NUM
dti-3495	478	2	.	.	PUNCT
dti-3495	479	1	crossref	crossref	PROPN
dti-3495	479	2	pubmed	pubmed	PROPN
dti-3495	479	3	19	19	NUM
dti-3495	479	4	.	.	PUNCT
dti-3495	480	1	singh	singh	PROPN
dti-3495	480	2	sv	sv	PROPN
dti-3495	480	3	,	,	PUNCT
dti-3495	480	4	manhas	manha	VERB
dti-3495	480	5	a	a	DET
dti-3495	480	6	,	,	PUNCT
dti-3495	480	7	singh	singh	PROPN
dti-3495	480	8	sp	sp	PROPN
dti-3495	480	9	,	,	PUNCT
dti-3495	480	10	et	et	PROPN
dti-3495	480	11	al	al	PROPN
dti-3495	480	12	.	.	PUNCT
dti-3495	481	1	a	a	DET
dti-3495	481	2	phenolic	phenolic	ADJ
dti-3495	481	3	glycoside	glycoside	NOUN
dti-3495	481	4	from	from	ADP
dti-3495	481	5	flacourtia	flacourtia	PROPN
dti-3495	481	6	indica	indica	PROPN
dti-3495	481	7	induces	induce	VERB
dti-3495	481	8	heme	heme	NOUN
dti-3495	481	9	mediated	mediate	VERB
dti-3495	481	10	oxidative	oxidative	ADJ
dti-3495	481	11	stress	stress	NOUN
dti-3495	481	12	in	in	ADP
dti-3495	481	13	plasmodium	plasmodium	NOUN
dti-3495	481	14	falciparum	falciparum	NOUN
dti-3495	481	15	and	and	CCONJ
dti-3495	481	16	attenuates	attenuate	VERB
dti-3495	481	17	malaria	malaria	ADJ
dti-3495	481	18	pathogenesis	pathogenesis	NOUN
dti-3495	481	19	in	in	ADP
dti-3495	481	20	mice	mouse	NOUN
dti-3495	481	21	.	.	PUNCT
dti-3495	482	1	phytomedicine	phytomedicine	NOUN
dti-3495	482	2	.	.	PUNCT
dti-3495	483	1	2017;30:1	2017;30:1	NUM
dti-3495	483	2	-	-	SYM
dti-3495	483	3	9	9	NUM
dti-3495	483	4	.	.	PUNCT
dti-3495	484	1	crossref	crossref	PROPN
dti-3495	484	2	pubmed	pubmed	PROPN
dti-3495	484	3	20	20	NUM
dti-3495	484	4	.	.	PUNCT
dti-3495	485	1	riyanto	riyanto	PROPN
dti-3495	485	2	s	s	PROPN
dti-3495	485	3	,	,	PUNCT
dti-3495	485	4	rohman	rohman	ADJ
dti-3495	485	5	a.	a.	NOUN
dti-3495	485	6	antioxidant	antioxidant	NOUN
dti-3495	485	7	activities	activity	NOUN
dti-3495	485	8	of	of	ADP
dti-3495	485	9	rambutan	rambutan	PROPN
dti-3495	485	10	(	(	PUNCT
dti-3495	485	11	nephelium	nephelium	NOUN
dti-3495	485	12	lappaceum	lappaceum	NOUN
dti-3495	485	13	l	l	NOUN
dti-3495	485	14	)	)	PUNCT
dti-3495	485	15	peel	peel	NOUN
dti-3495	485	16	in	in	ADP
dti-3495	485	17	-	-	PUNCT
dti-3495	485	18	vitro	vitro	X
dti-3495	485	19	.	.	PUNCT
dti-3495	486	1	food	food	NOUN
dti-3495	486	2	res	re	NOUN
dti-3495	486	3	.	.	PUNCT
dti-3495	487	1	2017;2(1	2017;2(1	NUM
dti-3495	487	2	):	):	PUNCT
dti-3495	487	3	119	119	NUM
dti-3495	487	4	-	-	SYM
dti-3495	487	5	123	123	NUM
dti-3495	487	6	.	.	PUNCT
dti-3495	488	1	crossref	crossref	PROPN
dti-3495	488	2	21	21	NUM
dti-3495	488	3	.	.	PUNCT
dti-3495	489	1	sagbo	sagbo	PROPN
dti-3495	489	2	ij	ij	PROPN
dti-3495	489	3	,	,	PUNCT
dti-3495	489	4	van	van	PROPN
dti-3495	489	5	de	de	PROPN
dti-3495	489	6	venter	venter	PROPN
dti-3495	489	7	m	m	PROPN
dti-3495	489	8	,	,	PUNCT
dti-3495	489	9	koekemoer	koekemoer	PROPN
dti-3495	489	10	t	t	PROPN
dti-3495	489	11	,	,	PUNCT
dti-3495	489	12	et	et	PROPN
dti-3495	489	13	al	al	PROPN
dti-3495	489	14	.	.	PROPN
dti-3495	490	1	in	in	ADP
dti-3495	490	2	-	-	PUNCT
dti-3495	490	3	vitro	vitro	X
dti-3495	490	4	antidiabetic	antidiabetic	ADJ
dti-3495	490	5	activity	activity	NOUN
dti-3495	490	6	and	and	CCONJ
dti-3495	490	7	mechanism	mechanism	NOUN
dti-3495	490	8	of	of	ADP
dti-3495	490	9	action	action	NOUN
dti-3495	490	10	of	of	ADP
dti-3495	490	11	brachylaena	brachylaena	PROPN
dti-3495	490	12	elliptica	elliptica	PROPN
dti-3495	490	13	(	(	PUNCT
dti-3495	490	14	thunb	thunb	NOUN
dti-3495	490	15	.	.	PUNCT
dti-3495	490	16	)	)	PUNCT
dti-3495	491	1	dc	dc	PROPN
dti-3495	491	2	.	.	PROPN
dti-3495	491	3	evid	evid	PROPN
dti-3495	491	4	based	base	VERB
dti-3495	491	5	complement	complement	PROPN
dti-3495	491	6	alternat	alternat	NOUN
dti-3495	491	7	med	me	VERB
dti-3495	491	8	.	.	PUNCT
dti-3495	492	1	2018;2018(1):4170372	2018;2018(1):4170372	PROPN
dti-3495	492	2	.	.	PUNCT
dti-3495	493	1	crossref	crossref	PROPN
dti-3495	493	2	pubmed	pubmed	PROPN
dti-3495	493	3	22	22	NUM
dti-3495	493	4	.	.	PUNCT
dti-3495	494	1	telagari	telagari	PROPN
dti-3495	494	2	m	m	PROPN
dti-3495	494	3	,	,	PUNCT
dti-3495	494	4	hullatti	hullatti	PROPN
dti-3495	494	5	k.	k.	PROPN
dti-3495	494	6	in	in	AUX
dti-3495	494	7	-	-	PUNCT
dti-3495	494	8	vitro	vitro	VERB
dti-3495	494	9	α	α	NOUN
dti-3495	494	10	-	-	NOUN
dti-3495	494	11	amylase	amylase	NOUN
dti-3495	494	12	and	and	CCONJ
dti-3495	494	13	α	α	NOUN
dti-3495	494	14	-	-	ADJ
dti-3495	494	15	glucosidase	glucosidase	ADJ
dti-3495	494	16	inhibitory	inhibitory	ADJ
dti-3495	494	17	activity	activity	NOUN
dti-3495	494	18	of	of	ADP
dti-3495	494	19	adiantum	adiantum	ADJ
dti-3495	494	20	caudatum	caudatum	NOUN
dti-3495	494	21	linn	linn	PROPN
dti-3495	494	22	.	.	PUNCT
dti-3495	495	1	and	and	CCONJ
dti-3495	495	2	celosia	celosia	NOUN
dti-3495	495	3	argentea	argentea	PROPN
dti-3495	495	4	linn	linn	PROPN
dti-3495	495	5	.	.	PUNCT
dti-3495	496	1	extracts	extract	NOUN
dti-3495	496	2	and	and	CCONJ
dti-3495	496	3	fractions	fraction	NOUN
dti-3495	496	4	.	.	PUNCT
dti-3495	497	1	indian	indian	PROPN
dti-3495	497	2	j	j	PROPN
dti-3495	497	3	pharmacol	pharmacol	PROPN
dti-3495	497	4	.	.	PUNCT
dti-3495	498	1	2015;47(4):425	2015;47(4):425	NUM
dti-3495	498	2	-	-	SYM
dti-3495	498	3	429	429	NUM
dti-3495	498	4	.	.	PUNCT
dti-3495	499	1	crossref	crossref	PROPN
dti-3495	499	2	pubmed	pubmed	PROPN
dti-3495	499	3	23	23	NUM
dti-3495	499	4	.	.	PUNCT
dti-3495	500	1	patel	patel	PROPN
dti-3495	500	2	d	d	PROPN
dti-3495	500	3	,	,	PUNCT
dti-3495	500	4	kumar	kumar	PROPN
dti-3495	500	5	r	r	PROPN
dti-3495	500	6	,	,	PUNCT
dti-3495	500	7	kumar	kumar	PROPN
dti-3495	500	8	m	m	PROPN
dti-3495	500	9	,	,	PUNCT
dti-3495	500	10	et	et	PROPN
dti-3495	500	11	al	al	PROPN
dti-3495	500	12	.	.	PUNCT
dti-3495	500	13	evaluation	evaluation	NOUN
dti-3495	500	14	of	of	ADP
dti-3495	500	15	in	in	ADP
dti-3495	500	16	vitro	vitro	X
dti-3495	500	17	aldose	aldose	PRON
dti-3495	500	18	reductase	reductase	NOUN
dti-3495	500	19	inhibitory	inhibitory	ADJ
dti-3495	500	20	potential	potential	NOUN
dti-3495	500	21	of	of	ADP
dti-3495	500	22	different	different	ADJ
dti-3495	500	23	fraction	fraction	NOUN
dti-3495	500	24	of	of	ADP
dti-3495	500	25	hybanthus	hybanthus	PROPN
dti-3495	500	26	enneaspermus	enneaspermus	PROPN
dti-3495	501	1	linn	linn	PROPN
dti-3495	501	2	f.	f.	PROPN
dti-3495	501	3	muell	muell	PROPN
dti-3495	501	4	.	.	PUNCT
dti-3495	502	1	asian	asian	PROPN
dti-3495	502	2	pac	pac	PROPN
dti-3495	502	3	j	j	PROPN
dti-3495	502	4	trop	trop	X
dti-3495	502	5	biomed	biome	VERB
dti-3495	502	6	.	.	PUNCT
dti-3495	503	1	2012;2(2):134	2012;2(2):134	NUM
dti-3495	503	2	-	-	SYM
dti-3495	503	3	139	139	NUM
dti-3495	503	4	.	.	PUNCT
dti-3495	504	1	crossref	crossref	PROPN
dti-3495	504	2	pubmed	pubmed	PROPN
dti-3495	504	3	24	24	NUM
dti-3495	504	4	.	.	PUNCT
dti-3495	505	1	vivek	vivek	PROPN
dti-3495	505	2	-	-	PUNCT
dti-3495	505	3	ananth	ananth	PROPN
dti-3495	505	4	rp	rp	NOUN
dti-3495	505	5	,	,	PUNCT
dti-3495	505	6	mohanraj	mohanraj	PROPN
dti-3495	505	7	k	k	PROPN
dti-3495	505	8	,	,	PUNCT
dti-3495	505	9	sahoo	sahoo	PROPN
dti-3495	505	10	ak	ak	PROPN
dti-3495	505	11	,	,	PUNCT
dti-3495	505	12	et	et	PROPN
dti-3495	505	13	al	al	PROPN
dti-3495	505	14	.	.	PROPN
dti-3495	505	15	imppat	imppat	PROPN
dti-3495	505	16	2.0	2.0	NUM
dti-3495	505	17	:	:	PUNCT
dti-3495	505	18	an	an	DET
dti-3495	505	19	enhanced	enhance	VERB
dti-3495	505	20	and	and	CCONJ
dti-3495	505	21	expanded	expand	VERB
dti-3495	505	22	phytochemical	phytochemical	ADJ
dti-3495	505	23	atlas	atlas	PROPN
dti-3495	505	24	of	of	ADP
dti-3495	505	25	indian	indian	ADJ
dti-3495	505	26	medicinal	medicinal	ADJ
dti-3495	505	27	plants	plant	NOUN
dti-3495	505	28	.	.	PUNCT
dti-3495	506	1	acs	acs	PROPN
dti-3495	506	2	omega	omega	PROPN
dti-3495	506	3	.	.	PUNCT
dti-3495	507	1	2023;8(9):8827	2023;8(9):8827	PROPN
dti-3495	507	2	-	-	SYM
dti-3495	507	3	8845	8845	NUM
dti-3495	507	4	.	.	PUNCT
dti-3495	508	1	crossref	crossref	PROPN
dti-3495	508	2	pubmed	pubmed	PROPN
dti-3495	508	3	25	25	NUM
dti-3495	508	4	.	.	PUNCT
dti-3495	509	1	nakamura	nakamura	PROPN
dti-3495	509	2	y	y	PROPN
dti-3495	509	3	,	,	PUNCT
dti-3495	509	4	afendi	afendi	PROPN
dti-3495	509	5	fm	fm	PROPN
dti-3495	509	6	,	,	PUNCT
dti-3495	509	7	parvin	parvin	PROPN
dti-3495	509	8	ak	ak	PROPN
dti-3495	509	9	,	,	PUNCT
dti-3495	509	10	et	et	PROPN
dti-3495	509	11	al	al	PROPN
dti-3495	509	12	.	.	PUNCT
dti-3495	509	13	knapsack	knapsack	NOUN
dti-3495	509	14	metabolite	metabolite	NOUN
dti-3495	509	15	activity	activity	NOUN
dti-3495	509	16	database	database	NOUN
dti-3495	509	17	for	for	ADP
dti-3495	509	18	retrieving	retrieve	VERB
dti-3495	509	19	the	the	DET
dti-3495	509	20	relationships	relationship	NOUN
dti-3495	509	21	between	between	ADP
dti-3495	509	22	metabolites	metabolite	NOUN
dti-3495	509	23	and	and	CCONJ
dti-3495	509	24	biological	biological	ADJ
dti-3495	509	25	activities	activity	NOUN
dti-3495	509	26	.	.	PUNCT
dti-3495	510	1	plant	plant	NOUN
dti-3495	510	2	cell	cell	NOUN
dti-3495	510	3	physiol	physiol	NOUN
dti-3495	510	4	.	.	PUNCT
dti-3495	511	1	2014	2014	NUM
dti-3495	511	2	;	;	PUNCT
dti-3495	512	1	55(1):e7	55(1):e7	NUM
dti-3495	512	2	.	.	PUNCT
dti-3495	513	1	crossref	crossref	PROPN
dti-3495	513	2	pubmed	pubmed	PROPN
dti-3495	513	3	26	26	NUM
dti-3495	513	4	.	.	PUNCT
dti-3495	514	1	daina	daina	PROPN
dti-3495	514	2	a	a	PROPN
dti-3495	514	3	,	,	PUNCT
dti-3495	514	4	michielin	michielin	PROPN
dti-3495	514	5	o	o	NOUN
dti-3495	514	6	,	,	PUNCT
dti-3495	514	7	zoete	zoete	PROPN
dti-3495	514	8	v.	v.	ADP
dti-3495	514	9	swisstargetprediction	swisstargetprediction	PROPN
dti-3495	514	10	:	:	PUNCT
dti-3495	514	11	updated	update	VERB
dti-3495	514	12	data	datum	NOUN
dti-3495	514	13	and	and	CCONJ
dti-3495	514	14	new	new	ADJ
dti-3495	514	15	features	feature	NOUN
dti-3495	514	16	for	for	ADP
dti-3495	514	17	efficient	efficient	ADJ
dti-3495	514	18	prediction	prediction	NOUN
dti-3495	514	19	of	of	ADP
dti-3495	514	20	protein	protein	NOUN
dti-3495	514	21	targets	target	NOUN
dti-3495	514	22	of	of	ADP
dti-3495	514	23	small	small	ADJ
dti-3495	514	24	molecules	molecule	NOUN
dti-3495	514	25	.	.	PUNCT
dti-3495	515	1	nucleic	nucleic	ADJ
dti-3495	515	2	acids	acid	NOUN
dti-3495	515	3	res	re	NOUN
dti-3495	515	4	.	.	PUNCT
dti-3495	515	5	2019;47(w1	2019;47(w1	NUM
dti-3495	515	6	):	):	PUNCT
dti-3495	515	7	w357	w357	PROPN
dti-3495	515	8	-	-	PUNCT
dti-3495	515	9	w364	w364	PROPN
dti-3495	515	10	.	.	PUNCT
dti-3495	516	1	crossref	crossref	PROPN
dti-3495	516	2	pubmed	pubmed	PROPN
dti-3495	516	3	27	27	NUM
dti-3495	516	4	.	.	PUNCT
dti-3495	517	1	kuhn	kuhn	PROPN
dti-3495	517	2	m	m	PROPN
dti-3495	517	3	,	,	PUNCT
dti-3495	517	4	szklarczyk	szklarczyk	X
dti-3495	517	5	d	d	NOUN
dti-3495	517	6	,	,	PUNCT
dti-3495	517	7	pletscher	pletscher	NOUN
dti-3495	517	8	-	-	PUNCT
dti-3495	517	9	frankild	frankild	NOUN
dti-3495	517	10	s	s	PROPN
dti-3495	517	11	,	,	PUNCT
dti-3495	517	12	et	et	PROPN
dti-3495	517	13	al	al	PROPN
dti-3495	517	14	.	.	PROPN
dti-3495	517	15	stitch	stitch	VERB
dti-3495	517	16	4	4	NUM
dti-3495	517	17	:	:	PUNCT
dti-3495	517	18	integration	integration	NOUN
dti-3495	517	19	of	of	ADP
dti-3495	517	20	protein	protein	NOUN
dti-3495	517	21	-	-	PUNCT
dti-3495	517	22	chemical	chemical	NOUN
dti-3495	517	23	interactions	interaction	NOUN
dti-3495	517	24	with	with	ADP
dti-3495	517	25	user	user	NOUN
dti-3495	517	26	data	data	PROPN
dti-3495	517	27	.	.	PUNCT
dti-3495	518	1	nucleic	nucleic	ADJ
dti-3495	518	2	acids	acid	NOUN
dti-3495	518	3	res	re	NOUN
dti-3495	518	4	.	.	PUNCT
dti-3495	519	1	2014;42(database	2014;42(database	ADJ
dti-3495	519	2	issue):d401	issue):d401	PROPN
dti-3495	519	3	-	-	PUNCT
dti-3495	519	4	d407	d407	PROPN
dti-3495	519	5	.	.	PUNCT
dti-3495	520	1	crossref	crossref	PROPN
dti-3495	520	2	pubmed	pubmed	PROPN
dti-3495	520	3	28	28	PROPN
dti-3495	520	4	.	.	PUNCT
dti-3495	521	1	barrett	barrett	PROPN
dti-3495	521	2	t	t	PROPN
dti-3495	521	3	,	,	PUNCT
dti-3495	521	4	wilhite	wilhite	PROPN
dti-3495	521	5	se	se	PROPN
dti-3495	521	6	,	,	PUNCT
dti-3495	521	7	ledoux	ledoux	PROPN
dti-3495	521	8	p	p	PROPN
dti-3495	521	9	,	,	PUNCT
dti-3495	521	10	et	et	PROPN
dti-3495	521	11	al	al	PROPN
dti-3495	521	12	.	.	PUNCT
dti-3495	522	1	ncbi	ncbi	PROPN
dti-3495	522	2	geo	geo	PROPN
dti-3495	522	3	:	:	PUNCT
dti-3495	522	4	archive	archive	NOUN
dti-3495	522	5	for	for	ADP
dti-3495	522	6	functional	functional	ADJ
dti-3495	522	7	genomics	genomic	NOUN
dti-3495	522	8	data	datum	NOUN
dti-3495	522	9	sets	set	NOUN
dti-3495	522	10	--	--	PUNCT
dti-3495	522	11	update	update	NOUN
dti-3495	522	12	.	.	PUNCT
dti-3495	523	1	nucleic	nucleic	ADJ
dti-3495	523	2	acids	acid	NOUN
dti-3495	523	3	res	re	NOUN
dti-3495	523	4	.	.	PUNCT
dti-3495	524	1	2013;41(database	2013;41(database	PROPN
dti-3495	524	2	issue):d991	issue):d991	PROPN
dti-3495	524	3	-	-	PUNCT
dti-3495	524	4	d995	d995	PROPN
dti-3495	524	5	.	.	PUNCT
dti-3495	525	1	pubmed	pubmed	PROPN
dti-3495	525	2	29	29	NUM
dti-3495	525	3	.	.	PUNCT
dti-3495	526	1	huang	huang	PROPN
dti-3495	526	2	dw	dw	PROPN
dti-3495	526	3	,	,	PUNCT
dti-3495	526	4	sherman	sherman	PROPN
dti-3495	526	5	bt	bt	PROPN
dti-3495	526	6	,	,	PUNCT
dti-3495	526	7	tan	tan	PROPN
dti-3495	526	8	q	q	PROPN
dti-3495	526	9	,	,	PUNCT
dti-3495	526	10	et	et	PROPN
dti-3495	526	11	al	al	PROPN
dti-3495	526	12	.	.	PUNCT
dti-3495	527	1	david	david	PROPN
dti-3495	527	2	bioinformatics	bioinformatics	PROPN
dti-3495	527	3	resources	resource	NOUN
dti-3495	527	4	:	:	PUNCT
dti-3495	527	5	expanded	expand	VERB
dti-3495	527	6	annotation	annotation	NOUN
dti-3495	527	7	database	database	NOUN
dti-3495	527	8	and	and	CCONJ
dti-3495	527	9	novel	novel	ADJ
dti-3495	527	10	algorithms	algorithm	NOUN
dti-3495	527	11	to	to	PART
dti-3495	527	12	better	well	ADV
dti-3495	527	13	extract	extract	VERB
dti-3495	527	14	biology	biology	NOUN
dti-3495	527	15	from	from	ADP
dti-3495	527	16	large	large	ADJ
dti-3495	527	17	gene	gene	NOUN
dti-3495	527	18	lists	list	NOUN
dti-3495	527	19	.	.	PUNCT
dti-3495	528	1	nucleic	nucleic	ADJ
dti-3495	528	2	acids	acid	NOUN
dti-3495	528	3	res	re	NOUN
dti-3495	528	4	.	.	PUNCT
dti-3495	529	1	2007;35(web	2007;35(web	NUM
dti-3495	529	2	server	server	NOUN
dti-3495	529	3	issue)(suppl	issue)(suppl	NOUN
dti-3495	529	4	2):w169	2):w169	NUM
dti-3495	529	5	-	-	SYM
dti-3495	529	6	75	75	NUM
dti-3495	529	7	.	.	PUNCT
dti-3495	530	1	crossref	crossref	PROPN
dti-3495	530	2	pubmed	pubmed	PROPN
dti-3495	530	3	30	30	PROPN
dti-3495	530	4	.	.	PUNCT
dti-3495	531	1	shannon	shannon	PROPN
dti-3495	531	2	p	p	PROPN
dti-3495	531	3	,	,	PUNCT
dti-3495	531	4	markiel	markiel	VERB
dti-3495	531	5	a	a	DET
dti-3495	531	6	,	,	PUNCT
dti-3495	531	7	ozier	ozier	ADJ
dti-3495	531	8	o	o	NOUN
dti-3495	531	9	,	,	PUNCT
dti-3495	531	10	et	et	PROPN
dti-3495	531	11	al	al	PROPN
dti-3495	531	12	.	.	PROPN
dti-3495	531	13	cytoscape	cytoscape	PROPN
dti-3495	531	14	:	:	PUNCT
dti-3495	531	15	a	a	DET
dti-3495	531	16	software	software	NOUN
dti-3495	531	17	environment	environment	NOUN
dti-3495	531	18	for	for	ADP
dti-3495	531	19	integrated	integrated	ADJ
dti-3495	531	20	models	model	NOUN
dti-3495	531	21	of	of	ADP
dti-3495	531	22	biomolecular	biomolecular	ADJ
dti-3495	531	23	interaction	interaction	NOUN
dti-3495	531	24	networks	network	NOUN
dti-3495	531	25	.	.	PUNCT
dti-3495	532	1	genome	genome	NOUN
dti-3495	532	2	res	re	NOUN
dti-3495	532	3	.	.	PUNCT
dti-3495	533	1	2003;13(11):2498	2003;13(11):2498	NUM
dti-3495	533	2	-	-	SYM
dti-3495	533	3	2504	2504	NUM
dti-3495	533	4	.	.	PUNCT
dti-3495	534	1	crossref	crossref	PROPN
dti-3495	534	2	pubmed	pubmed	PROPN
dti-3495	534	3	31	31	NUM
dti-3495	534	4	.	.	PUNCT
dti-3495	535	1	von	von	PROPN
dti-3495	535	2	mering	mere	VERB
dti-3495	535	3	c	c	PROPN
dti-3495	535	4	,	,	PUNCT
dti-3495	535	5	huynen	huynen	PROPN
dti-3495	535	6	m	m	PROPN
dti-3495	535	7	,	,	PUNCT
dti-3495	535	8	jaeggi	jaeggi	PROPN
dti-3495	535	9	d	d	PROPN
dti-3495	535	10	,	,	PUNCT
dti-3495	535	11	et	et	PROPN
dti-3495	535	12	al	al	PROPN
dti-3495	535	13	.	.	PROPN
dti-3495	535	14	string	string	PROPN
dti-3495	535	15	:	:	PUNCT
dti-3495	535	16	a	a	DET
dti-3495	535	17	database	database	NOUN
dti-3495	535	18	of	of	ADP
dti-3495	535	19	predicted	predict	VERB
dti-3495	535	20	functional	functional	ADJ
dti-3495	535	21	associations	association	NOUN
dti-3495	535	22	between	between	ADP
dti-3495	535	23	proteins	protein	NOUN
dti-3495	535	24	.	.	PUNCT
dti-3495	536	1	nucleic	nucleic	ADJ
dti-3495	536	2	acids	acid	NOUN
dti-3495	536	3	res	re	NOUN
dti-3495	536	4	.	.	PUNCT
dti-3495	537	1	2003;31(1):258	2003;31(1):258	PROPN
dti-3495	537	2	-	-	SYM
dti-3495	537	3	261	261	NUM
dti-3495	537	4	.	.	PUNCT
dti-3495	538	1	crossref	crossref	PROPN
dti-3495	538	2	pubmed	pubmed	PROPN
dti-3495	538	3	32	32	NUM
dti-3495	538	4	.	.	PUNCT
dti-3495	539	1	rose	rise	VERB
dti-3495	539	2	pw	pw	PROPN
dti-3495	539	3	,	,	PUNCT
dti-3495	539	4	bi	bi	PROPN
dti-3495	539	5	c	c	NOUN
dti-3495	539	6	,	,	PUNCT
dti-3495	539	7	bluhm	bluhm	PROPN
dti-3495	539	8	wf	wf	PROPN
dti-3495	539	9	,	,	PUNCT
dti-3495	539	10	et	et	PROPN
dti-3495	539	11	al	al	PROPN
dti-3495	539	12	.	.	PUNCT
dti-3495	540	1	the	the	DET
dti-3495	540	2	rcsb	rcsb	ADJ
dti-3495	540	3	protein	protein	NOUN
dti-3495	540	4	data	datum	NOUN
dti-3495	540	5	bank	bank	NOUN
dti-3495	540	6	:	:	PUNCT
dti-3495	540	7	new	new	ADJ
dti-3495	540	8	resources	resource	NOUN
dti-3495	540	9	for	for	ADP
dti-3495	540	10	research	research	NOUN
dti-3495	540	11	and	and	CCONJ
dti-3495	540	12	education	education	NOUN
dti-3495	540	13	.	.	PUNCT
dti-3495	541	1	nucleic	nucleic	ADJ
dti-3495	541	2	acids	acid	NOUN
dti-3495	541	3	res	re	NOUN
dti-3495	541	4	.	.	PUNCT
dti-3495	542	1	2013;41(database	2013;41(database	PROPN
dti-3495	542	2	issue):d475	issue):d475	PROPN
dti-3495	542	3	-	-	PUNCT
dti-3495	542	4	d482	d482	PROPN
dti-3495	542	5	.	.	PUNCT
dti-3495	543	1	pubmed	pubmed	PROPN
dti-3495	543	2	33	33	NUM
dti-3495	543	3	.	.	PUNCT
dti-3495	544	1	pettersen	pettersen	PROPN
dti-3495	544	2	ef	ef	PROPN
dti-3495	544	3	,	,	PUNCT
dti-3495	544	4	goddard	goddard	NOUN
dti-3495	544	5	td	td	PROPN
dti-3495	544	6	,	,	PUNCT
dti-3495	544	7	huang	huang	PROPN
dti-3495	544	8	cc	cc	PROPN
dti-3495	544	9	,	,	PUNCT
dti-3495	544	10	et	et	PROPN
dti-3495	544	11	al	al	PROPN
dti-3495	544	12	.	.	PROPN
dti-3495	544	13	ucsf	ucsf	PROPN
dti-3495	544	14	chimera	chimera	PROPN
dti-3495	544	15	—	—	PUNCT
dti-3495	544	16	a	a	DET
dti-3495	544	17	visualization	visualization	NOUN
dti-3495	544	18	system	system	NOUN
dti-3495	544	19	for	for	ADP
dti-3495	544	20	exploratory	exploratory	ADJ
dti-3495	544	21	research	research	NOUN
dti-3495	544	22	and	and	CCONJ
dti-3495	544	23	analysis	analysis	NOUN
dti-3495	544	24	.	.	PUNCT
dti-3495	545	1	j	j	PROPN
dti-3495	545	2	comput	comput	PROPN
dti-3495	545	3	chem	chem	NOUN
dti-3495	545	4	.	.	PUNCT
dti-3495	546	1	2004;25(13):1605	2004;25(13):1605	NUM
dti-3495	546	2	-	-	SYM
dti-3495	546	3	1612	1612	NUM
dti-3495	546	4	.	.	PUNCT
dti-3495	547	1	crossref	crossref	PROPN
dti-3495	547	2	pubmed	pubmed	PROPN
dti-3495	547	3	34	34	NUM
dti-3495	547	4	.	.	PUNCT
dti-3495	548	1	dundas	dundas	PROPN
dti-3495	548	2	j	j	PROPN
dti-3495	548	3	,	,	PUNCT
dti-3495	548	4	ouyang	ouyang	PROPN
dti-3495	548	5	z	z	PROPN
dti-3495	548	6	,	,	PUNCT
dti-3495	548	7	tseng	tseng	PROPN
dti-3495	548	8	j	j	PROPN
dti-3495	548	9	,	,	PUNCT
dti-3495	548	10	et	et	PROPN
dti-3495	548	11	al	al	PROPN
dti-3495	548	12	.	.	PROPN
dti-3495	548	13	castp	castp	PROPN
dti-3495	548	14	:	:	PUNCT
dti-3495	548	15	computed	compute	VERB
dti-3495	548	16	atlas	atlas	PROPN
dti-3495	548	17	of	of	ADP
dti-3495	548	18	surface	surface	NOUN
dti-3495	548	19	topography	topography	NOUN
dti-3495	548	20	of	of	ADP
dti-3495	548	21	proteins	protein	NOUN
dti-3495	548	22	with	with	ADP
dti-3495	548	23	structural	structural	ADJ
dti-3495	548	24	and	and	CCONJ
dti-3495	548	25	topographical	topographical	ADJ
dti-3495	548	26	mapping	mapping	NOUN
dti-3495	548	27	of	of	ADP
dti-3495	548	28	functionally	functionally	ADV
dti-3495	548	29	annotated	annotate	VERB
dti-3495	548	30	residues	residue	NOUN
dti-3495	548	31	.	.	PUNCT
dti-3495	549	1	nucleic	nucleic	ADJ
dti-3495	549	2	acids	acid	NOUN
dti-3495	549	3	res	re	NOUN
dti-3495	549	4	.	.	PUNCT
dti-3495	550	1	2006;34(web	2006;34(web	NUM
dti-3495	550	2	server	server	NOUN
dti-3495	550	3	issue)(suppl	issue)(suppl	NOUN
dti-3495	550	4	2):w116	2):w116	NUM
dti-3495	550	5	-	-	SYM
dti-3495	550	6	8	8	NUM
dti-3495	550	7	.	.	PUNCT
dti-3495	551	1	crossref	crossref	PROPN
dti-3495	551	2	pubmed	pubmed	PROPN
dti-3495	551	3	35	35	NUM
dti-3495	551	4	.	.	PUNCT
dti-3495	552	1	sargis	sargis	PROPN
dti-3495	552	2	dallakyan	dallakyan	NOUN
dti-3495	552	3	,	,	PUNCT
dti-3495	552	4	arthur	arthur	PROPN
dti-3495	552	5	j	j	PROPN
dti-3495	552	6	olson	olson	PROPN
dti-3495	552	7	.	.	PUNCT
dti-3495	553	1	small	small	ADJ
dti-3495	553	2	-	-	PUNCT
dti-3495	553	3	molecule	molecule	NOUN
dti-3495	553	4	library	library	NOUN
dti-3495	553	5	screening	screening	NOUN
dti-3495	553	6	by	by	ADP
dti-3495	553	7	docking	dock	VERB
dti-3495	553	8	with	with	ADP
dti-3495	553	9	pyrx	pyrx	NOUN
dti-3495	553	10	.	.	PUNCT
dti-3495	554	1	methods	method	NOUN
dti-3495	554	2	mol	mol	ADP
dti-3495	554	3	biol	biol	PROPN
dti-3495	554	4	.	.	PUNCT
dti-3495	555	1	2015;1263:243	2015;1263:243	X
dti-3495	555	2	-	-	PUNCT
dti-3495	555	3	50	50	NUM
dti-3495	555	4	.	.	PUNCT
dti-3495	556	1	crossref	crossref	PROPN
dti-3495	556	2	36	36	NUM
dti-3495	556	3	.	.	PUNCT
dti-3495	557	1	chen	chen	PROPN
dti-3495	557	2	m	m	PROPN
dti-3495	557	3	,	,	PUNCT
dti-3495	557	4	chen	chen	PROPN
dti-3495	557	5	x	x	PROPN
dti-3495	557	6	,	,	PUNCT
dti-3495	557	7	chen	chen	PROPN
dti-3495	557	8	q	q	PROPN
dti-3495	557	9	,	,	PUNCT
dti-3495	557	10	et	et	PROPN
dti-3495	557	11	al	al	PROPN
dti-3495	557	12	.	.	PUNCT
dti-3495	557	13	potential	potential	ADJ
dti-3495	557	14	candidates	candidate	NOUN
dti-3495	557	15	from	from	ADP
dti-3495	557	16	a	a	DET
dti-3495	557	17	functional	functional	ADJ
dti-3495	557	18	food	food	NOUN
dti-3495	557	19	zanthoxyli	zanthoxyli	PROPN
dti-3495	557	20	pericarpium	pericarpium	NOUN
dti-3495	557	21	(	(	PUNCT
dti-3495	557	22	sichuan	sichuan	PROPN
dti-3495	557	23	pepper	pepper	NOUN
dti-3495	557	24	)	)	PUNCT
dti-3495	557	25	for	for	ADP
dti-3495	557	26	the	the	DET
dti-3495	557	27	management	management	NOUN
dti-3495	557	28	of	of	ADP
dti-3495	557	29	hyperuricemia	hyperuricemia	NOUN
dti-3495	557	30	:	:	PUNCT
dti-3495	557	31	high	high	ADJ
dti-3495	557	32	-	-	PUNCT
dti-3495	557	33	through	through	ADP
dti-3495	557	34	virtual	virtual	ADJ
dti-3495	557	35	screening	screening	NOUN
dti-3495	557	36	,	,	PUNCT
dti-3495	557	37	network	network	NOUN
dti-3495	557	38	pharmacology	pharmacology	NOUN
dti-3495	557	39	and	and	CCONJ
dti-3495	557	40	dynamics	dynamic	NOUN
dti-3495	557	41	simulations	simulation	NOUN
dti-3495	557	42	.	.	PUNCT
dti-3495	558	1	front	front	ADJ
dti-3495	558	2	endocrinol	endocrinol	NOUN
dti-3495	558	3	(	(	PUNCT
dti-3495	558	4	lausanne	lausanne	PROPN
dti-3495	558	5	)	)	PUNCT
dti-3495	558	6	.	.	PUNCT
dti-3495	559	1	2024;15:1436360	2024;15:1436360	NUM
dti-3495	559	2	.	.	X
dti-3495	559	3	crossref	crossref	PROPN
dti-3495	559	4	pubmed	pubmed	PROPN
dti-3495	559	5	37	37	NUM
dti-3495	559	6	.	.	PUNCT
dti-3495	560	1	discovery	discovery	PROPN
dti-3495	560	2	studio	studio	NOUN
dti-3495	560	3	.	.	PUNCT
dti-3495	561	1	accelrys2.1	accelrys2.1	PROPN
dti-3495	561	2	,	,	PUNCT
dti-3495	561	3	2008	2008	NUM
dti-3495	561	4	.	.	PUNCT
dti-3495	562	1	420	420	NUM
dti-3495	562	2	.	.	PUNCT
dti-3495	563	1	online	online	ADV
dti-3495	563	2	(	(	PUNCT
dti-3495	563	3	accessed	access	VERB
dti-3495	563	4	february	february	NOUN
dti-3495	563	5	2025	2025	NUM
dti-3495	563	6	)	)	PUNCT
dti-3495	564	1	https://doi.org/10.3389/fendo.2023.1161521	https://doi.org/10.3389/fendo.2023.1161521	NOUN
dti-3495	564	2	https://pubmed.ncbi.nlm.nih.gov/37152942	https://pubmed.ncbi.nlm.nih.gov/37152942	VERB
dti-3495	564	3	https://doi.org/10.1080/14786419.2019.1633650	https://doi.org/10.1080/14786419.2019.1633650	PROPN
dti-3495	564	4	https://pubmed.ncbi.nlm.nih.gov/31232117	https://pubmed.ncbi.nlm.nih.gov/31232117	PROPN
dti-3495	564	5	https://doi.org/10.1016/s0140-6736(22)01655-5	https://doi.org/10.1016/s0140-6736(22)01655-5	VERB
dti-3495	564	6	https://pubmed.ncbi.nlm.nih.gov/36332637	https://pubmed.ncbi.nlm.nih.gov/36332637	VERB
dti-3495	564	7	https://doi.org/10.3390/ijms21176275	https://doi.org/10.3390/ijms21176275	VERB
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dti-3495	564	11	https://doi.org/10.2147/dmso.s319895	https://doi.org/10.2147/dmso.s319895	PROPN
dti-3495	564	12	https://pubmed.ncbi.nlm.nih.gov/34413662	https://pubmed.ncbi.nlm.nih.gov/34413662	PROPN
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dti-3495	565	1	https://doi.org/10.1002/med.21867	https://doi.org/10.1002/med.21867	PRON
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dti-3495	565	9	https://doi.org/10.2174/1568026620666200516153136	https://doi.org/10.2174/1568026620666200516153136	AUX
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dti-3495	565	11	https://doi.org/10.1016/j.parint.2022.102675	https://doi.org/10.1016/j.parint.2022.102675	VERB
dti-3495	565	12	https://pubmed.ncbi.nlm.nih.gov/36089201	https://pubmed.ncbi.nlm.nih.gov/36089201	VERB
dti-3495	566	1	https://doi.org/10.1016/j.phymed.2017.04.010	https://doi.org/10.1016/j.phymed.2017.04.010	NOUN
dti-3495	566	2	https://pubmed.ncbi.nlm.nih.gov/28545664	https://pubmed.ncbi.nlm.nih.gov/28545664	PROPN
dti-3495	566	3	https://doi.org/10.26656/fr.2017.2(1).150	https://doi.org/10.26656/fr.2017.2(1).150	PROPN
dti-3495	566	4	https://doi.org/10.1155/2018/4170372	https://doi.org/10.1155/2018/4170372	PROPN
dti-3495	566	5	https://pubmed.ncbi.nlm.nih.gov/30108655	https://pubmed.ncbi.nlm.nih.gov/30108655	PROPN
dti-3495	567	1	https://doi.org/10.4103/0253-7613.161270	https://doi.org/10.4103/0253-7613.161270	PROPN
dti-3495	568	1	https://pubmed.ncbi.nlm.nih.gov/26288477	https://pubmed.ncbi.nlm.nih.gov/26288477	PROPN
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dti-3495	568	3	https://pubmed.ncbi.nlm.nih.gov/23569883	https://pubmed.ncbi.nlm.nih.gov/23569883	PROPN
dti-3495	568	4	https://doi.org/10.1021/acsomega.3c00156	https://doi.org/10.1021/acsomega.3c00156	PROPN
dti-3495	569	1	https://pubmed.ncbi.nlm.nih.gov/36910986	https://pubmed.ncbi.nlm.nih.gov/36910986	SCONJ
dti-3495	569	2	https://doi.org/10.1093/pcp/pct176	https://doi.org/10.1093/pcp/pct176	PROPN
dti-3495	569	3	https://pubmed.ncbi.nlm.nih.gov/24285751	https://pubmed.ncbi.nlm.nih.gov/24285751	PROPN
dti-3495	569	4	https://doi.org/10.1093/nar/gkz382	https://doi.org/10.1093/nar/gkz382	PROPN
dti-3495	569	5	https://pubmed.ncbi.nlm.nih.gov/31106366	https://pubmed.ncbi.nlm.nih.gov/31106366	PROPN
dti-3495	569	6	https://doi.org/10.1093/nar/gkt1207	https://doi.org/10.1093/nar/gkt1207	VERB
dti-3495	569	7	https://pubmed.ncbi.nlm.nih.gov/24293645	https://pubmed.ncbi.nlm.nih.gov/24293645	PROPN
dti-3495	570	1	https://pubmed.ncbi.nlm.nih.gov/23193258	https://pubmed.ncbi.nlm.nih.gov/23193258	PROPN
dti-3495	570	2	https://doi.org/10.1093/nar/gkm415	https://doi.org/10.1093/nar/gkm415	PROPN
dti-3495	570	3	https://pubmed.ncbi.nlm.nih.gov/17576678	https://pubmed.ncbi.nlm.nih.gov/17576678	NOUN
dti-3495	570	4	https://doi.org/10.1101/gr.1239303	https://doi.org/10.1101/gr.1239303	NOUN
dti-3495	570	5	https://pubmed.ncbi.nlm.nih.gov/14597658	https://pubmed.ncbi.nlm.nih.gov/14597658	PROPN
dti-3495	570	6	https://doi.org/10.1093/nar/gkg034	https://doi.org/10.1093/nar/gkg034	NOUN
dti-3495	570	7	https://pubmed.ncbi.nlm.nih.gov/12519996	https://pubmed.ncbi.nlm.nih.gov/12519996	VERB
dti-3495	570	8	https://pubmed.ncbi.nlm.nih.gov/23193259	https://pubmed.ncbi.nlm.nih.gov/23193259	NOUN
dti-3495	570	9	https://doi.org/10.1002/jcc.20084	https://doi.org/10.1002/jcc.20084	PROPN
dti-3495	570	10	https://pubmed.ncbi.nlm.nih.gov/15264254	https://pubmed.ncbi.nlm.nih.gov/15264254	VERB
dti-3495	571	1	https://doi.org/10.1093/nar/gkl282	https://doi.org/10.1093/nar/gkl282	PROPN
dti-3495	571	2	https://pubmed.ncbi.nlm.nih.gov/16844972	https://pubmed.ncbi.nlm.nih.gov/16844972	PROPN
dti-3495	571	3	https://doi.org/10.1007/978-1-4939-2269-7_19	https://doi.org/10.1007/978-1-4939-2269-7_19	ADJ
dti-3495	571	4	https://doi.org/10.3389/fendo.2024.1436360	https://doi.org/10.3389/fendo.2024.1436360	PROPN
dti-3495	571	5	https://pubmed.ncbi.nlm.nih.gov/39722812	https://pubmed.ncbi.nlm.nih.gov/39722812	PROPN
dti-3495	571	6	https://discover.3ds.com/discovery-studio-visualizer-download	https://discover.3ds.com/discovery-studio-visualizer-download	PROPN
dti-3495	571	7	in	in	ADP
dti-3495	571	8	silico	silico	NOUN
dti-3495	571	9	anti	anti	ADJ
dti-3495	571	10	-	-	ADJ
dti-3495	571	11	diabetic	diabetic	ADJ
dti-3495	571	12	potential	potential	NOUN
dti-3495	571	13	of	of	ADP
dti-3495	571	14	vigna	vigna	PROPN
dti-3495	571	15	unguiculata90	unguiculata90	PROPN
dti-3495	571	16	©	©	PROPN
dti-3495	571	17	2025	2025	NUM
dti-3495	571	18	the	the	DET
dti-3495	571	19	authors	author	NOUN
dti-3495	571	20	.	.	PUNCT
dti-3495	572	1	drug	drug	NOUN
dti-3495	572	2	target	target	NOUN
dti-3495	572	3	insights	insight	NOUN
dti-3495	572	4	issn	issn	VERB
dti-3495	572	5	1177	1177	NUM
dti-3495	572	6	-	-	SYM
dti-3495	572	7	3928	3928	NUM
dti-3495	572	8	www.aboutscience.eu/dti	www.aboutscience.eu/dti	VERB
dti-3495	572	9	38	38	NUM
dti-3495	572	10	.	.	PUNCT
dti-3495	573	1	bisht	bisht	PROPN
dti-3495	573	2	a	a	PRON
dti-3495	573	3	,	,	PUNCT
dti-3495	573	4	tewari	tewari	PROPN
dti-3495	573	5	d	d	PROPN
dti-3495	573	6	,	,	PUNCT
dti-3495	573	7	kumar	kumar	PROPN
dti-3495	573	8	s	s	PROPN
dti-3495	573	9	,	,	PUNCT
dti-3495	573	10	et	et	PROPN
dti-3495	573	11	al	al	PROPN
dti-3495	573	12	.	.	PUNCT
dti-3495	574	1	network	network	PROPN
dti-3495	574	2	pharmacology	pharmacology	NOUN
dti-3495	574	3	,	,	PUNCT
dti-3495	574	4	molecular	molecular	ADJ
dti-3495	574	5	docking	docking	NOUN
dti-3495	574	6	,	,	PUNCT
dti-3495	574	7	and	and	CCONJ
dti-3495	574	8	molecular	molecular	ADJ
dti-3495	574	9	dynamics	dynamic	NOUN
dti-3495	574	10	simulation	simulation	NOUN
dti-3495	574	11	to	to	PART
dti-3495	574	12	elucidate	elucidate	VERB
dti-3495	574	13	the	the	DET
dti-3495	574	14	mechanism	mechanism	NOUN
dti-3495	574	15	of	of	ADP
dti-3495	574	16	anti	anti	ADJ
dti-3495	574	17	-	-	ADJ
dti-3495	574	18	aging	aging	ADJ
dti-3495	574	19	action	action	NOUN
dti-3495	574	20	of	of	ADP
dti-3495	574	21	tinospora	tinospora	PROPN
dti-3495	574	22	cordifolia	cordifolia	PROPN
dti-3495	574	23	.	.	PUNCT
dti-3495	575	1	mol	mol	ADP
dti-3495	575	2	divers	diver	NOUN
dti-3495	575	3	.	.	PUNCT
dti-3495	576	1	2024;28(3):1743	2024;28(3):1743	NUM
dti-3495	576	2	-	-	SYM
dti-3495	576	3	1763	1763	NUM
dti-3495	576	4	.	.	PUNCT
dti-3495	577	1	crossref	crossref	PROPN
dti-3495	577	2	pubmed	pubmed	PROPN
dti-3495	577	3	39	39	NUM
dti-3495	577	4	.	.	PUNCT
dti-3495	578	1	joshi	joshi	PROPN
dti-3495	578	2	t	t	PROPN
dti-3495	578	3	,	,	PUNCT
dti-3495	578	4	joshi	joshi	PROPN
dti-3495	578	5	t	t	PROPN
dti-3495	578	6	,	,	PUNCT
dti-3495	578	7	sharma	sharma	PROPN
dti-3495	578	8	p	p	PROPN
dti-3495	578	9	,	,	PUNCT
dti-3495	578	10	et	et	PROPN
dti-3495	578	11	al	al	PROPN
dti-3495	578	12	.	.	PUNCT
dti-3495	579	1	molecular	molecular	ADJ
dti-3495	579	2	docking	docking	NOUN
dti-3495	579	3	and	and	CCONJ
dti-3495	579	4	molecular	molecular	ADJ
dti-3495	579	5	dynamics	dynamic	NOUN
dti-3495	579	6	simulation	simulation	NOUN
dti-3495	579	7	approach	approach	NOUN
dti-3495	579	8	to	to	ADP
dti-3495	579	9	screen	screen	VERB
dti-3495	579	10	natural	natural	ADJ
dti-3495	579	11	compounds	compound	NOUN
dti-3495	579	12	for	for	ADP
dti-3495	579	13	inhibition	inhibition	NOUN
dti-3495	579	14	of	of	ADP
dti-3495	579	15	xanthomonas	xanthomonas	PROPN
dti-3495	579	16	oryzae	oryzae	PROPN
dti-3495	579	17	pv	pv	AUX
dti-3495	579	18	.	.	PUNCT
dti-3495	580	1	oryzae	oryzae	NOUN
dti-3495	580	2	by	by	ADP
dti-3495	580	3	targeting	target	VERB
dti-3495	580	4	peptide	peptide	NOUN
dti-3495	580	5	deformylase	deformylase	NOUN
dti-3495	580	6	.	.	PUNCT
dti-3495	581	1	j	j	PROPN
dti-3495	581	2	biomol	biomol	PROPN
dti-3495	581	3	struct	struct	NOUN
dti-3495	581	4	dyn	dyn	NOUN
dti-3495	581	5	.	.	PUNCT
dti-3495	582	1	2021;39(3):823840	2021;39(3):823840	NUM
dti-3495	582	2	.	.	PUNCT
dti-3495	583	1	crossref	crossref	PROPN
dti-3495	583	2	pubmed	pubmed	PROPN
dti-3495	583	3	40	40	NUM
dti-3495	583	4	.	.	PUNCT
dti-3495	584	1	rajesh	rajesh	PROPN
dti-3495	584	2	gd	gd	PROPN
dti-3495	584	3	,	,	PUNCT
dti-3495	584	4	apte	apte	PROPN
dti-3495	584	5	k	k	PROPN
dti-3495	584	6	,	,	PUNCT
dti-3495	584	7	abhirami	abhirami	NOUN
dti-3495	584	8	pv	pv	PROPN
dti-3495	584	9	,	,	PUNCT
dti-3495	584	10	et	et	PROPN
dti-3495	584	11	al	al	PROPN
dti-3495	584	12	.	.	PROPN
dti-3495	584	13	comprehensive	comprehensive	PROPN
dti-3495	584	14	in	in	ADP
dti-3495	584	15	silico	silico	NOUN
dti-3495	584	16	analysis	analysis	NOUN
dti-3495	584	17	of	of	ADP
dti-3495	584	18	flavonoids	flavonoid	NOUN
dti-3495	584	19	in	in	ADP
dti-3495	584	20	breast	breast	NOUN
dti-3495	584	21	cancer	cancer	NOUN
dti-3495	584	22	using	use	VERB
dti-3495	584	23	molecular	molecular	ADJ
dti-3495	584	24	docking	docking	NOUN
dti-3495	584	25	,	,	PUNCT
dti-3495	584	26	adme	adme	NOUN
dti-3495	584	27	,	,	PUNCT
dti-3495	584	28	and	and	CCONJ
dti-3495	584	29	molecular	molecular	ADJ
dti-3495	584	30	dynamics	dynamic	NOUN
dti-3495	584	31	simulation	simulation	NOUN
dti-3495	584	32	approach	approach	NOUN
dti-3495	584	33	.	.	PUNCT
dti-3495	585	1	pept	pept	PROPN
dti-3495	585	2	sci	sci	PROPN
dti-3495	585	3	(	(	PUNCT
dti-3495	585	4	hoboken	hoboken	PROPN
dti-3495	585	5	)	)	PUNCT
dti-3495	585	6	.	.	PUNCT
dti-3495	586	1	2025;117(1):24391	2025;117(1):24391	NUM
dti-3495	586	2	.	.	PUNCT
dti-3495	587	1	crossref	crossref	PROPN
dti-3495	587	2	41	41	NUM
dti-3495	587	3	.	.	PUNCT
dti-3495	588	1	shirin	shirin	PROPN
dti-3495	588	2	hasani	hasani	PROPN
dti-3495	588	3	-	-	PUNCT
dti-3495	588	4	ranjbar	ranjbar	NOUN
dti-3495	588	5	,	,	PUNCT
dti-3495	588	6	bagher	bagher	NOUN
dti-3495	588	7	larijani	larijani	NOUN
dti-3495	588	8	,	,	PUNCT
dti-3495	588	9	mohammad	mohammad	PROPN
dti-3495	588	10	abdollahi	abdollahi	PROPN
dti-3495	588	11	.	.	PUNCT
dti-3495	589	1	a	a	DET
dti-3495	589	2	systematic	systematic	ADJ
dti-3495	589	3	review	review	NOUN
dti-3495	589	4	of	of	ADP
dti-3495	589	5	the	the	DET
dti-3495	589	6	potential	potential	ADJ
dti-3495	589	7	herbal	herbal	ADJ
dti-3495	589	8	sources	source	NOUN
dti-3495	589	9	of	of	ADP
dti-3495	589	10	future	future	ADJ
dti-3495	589	11	drugs	drug	NOUN
dti-3495	589	12	effective	effective	ADJ
dti-3495	589	13	in	in	ADP
dti-3495	589	14	oxidant	oxidant	NOUN
dti-3495	589	15	-	-	PUNCT
dti-3495	589	16	related	relate	VERB
dti-3495	589	17	.	.	PUNCT
dti-3495	590	1	inflam	inflam	PROPN
dti-3495	590	2	allergy	allergy	PROPN
dti-3495	590	3	–	–	PUNCT
dti-3495	590	4	drug	drug	NOUN
dti-3495	590	5	targets	target	NOUN
dti-3495	590	6	.	.	PUNCT
dti-3495	591	1	2009;8(1):2	2009;8(1):2	NUM
dti-3495	591	2	-	-	PUNCT
dti-3495	591	3	10	10	NUM
dti-3495	591	4	.	.	PUNCT
dti-3495	592	1	crossref	crossref	NOUN
dti-3495	592	2	.	.	PUNCT
dti-3495	593	1	42	42	NUM
dti-3495	593	2	.	.	PUNCT
dti-3495	594	1	mishra	mishra	PROPN
dti-3495	594	2	dsb	dsb	PROPN
dti-3495	594	3	.	.	PUNCT
dti-3495	595	1	an	an	DET
dti-3495	595	2	analytical	analytical	ADJ
dti-3495	595	3	review	review	NOUN
dti-3495	595	4	of	of	ADP
dti-3495	595	5	plants	plant	NOUN
dti-3495	595	6	for	for	ADP
dti-3495	595	7	anti	anti	ADJ
dti-3495	595	8	diabetic	diabetic	ADJ
dti-3495	595	9	activity	activity	NOUN
dti-3495	595	10	with	with	ADP
dti-3495	595	11	their	their	PRON
dti-3495	595	12	phytoconstituent	phytoconstituent	NOUN
dti-3495	595	13	&	&	CCONJ
dti-3495	595	14	mechanism	mechanism	NOUN
dti-3495	595	15	of	of	ADP
dti-3495	595	16	action	action	NOUN
dti-3495	595	17	.	.	PUNCT
dti-3495	596	1	int	int	PROPN
dti-3495	596	2	j	j	PROPN
dti-3495	596	3	pharm	pharm	PROPN
dti-3495	596	4	sci	sci	PROPN
dti-3495	596	5	res	re	NOUN
dti-3495	596	6	.	.	PUNCT
dti-3495	597	1	2009;1(1):29	2009;1(1):29	NUM
dti-3495	597	2	-	-	SYM
dti-3495	597	3	46	46	NUM
dti-3495	597	4	.	.	PUNCT
dti-3495	598	1	crossref	crossref	PROPN
dti-3495	598	2	43	43	NUM
dti-3495	598	3	.	.	PUNCT
dti-3495	599	1	ouassou	ouassou	PROPN
dti-3495	599	2	h	h	PROPN
dti-3495	599	3	,	,	PUNCT
dti-3495	599	4	zahidi	zahidi	PROPN
dti-3495	599	5	t	t	PROPN
dti-3495	599	6	,	,	PUNCT
dti-3495	599	7	bouknana	bouknana	PROPN
dti-3495	599	8	s	s	PROPN
dti-3495	599	9	,	,	PUNCT
dti-3495	599	10	et	et	PROPN
dti-3495	599	11	al	al	PROPN
dti-3495	599	12	.	.	PROPN
dti-3495	599	13	inhibition	inhibition	NOUN
dti-3495	599	14	of	of	ADP
dti-3495	599	15	α	α	NOUN
dti-3495	599	16	-	-	PUNCT
dti-3495	599	17	glucosidase	glucosidase	ADJ
dti-3495	599	18	,	,	PUNCT
dti-3495	599	19	intestinal	intestinal	ADJ
dti-3495	599	20	glucose	glucose	NOUN
dti-3495	599	21	absorption	absorption	NOUN
dti-3495	599	22	,	,	PUNCT
dti-3495	599	23	and	and	CCONJ
dti-3495	599	24	anti	anti	ADJ
dti-3495	599	25	-	-	ADJ
dti-3495	599	26	diabetic	diabetic	ADJ
dti-3495	599	27	properties	property	NOUN
dti-3495	599	28	by	by	ADP
dti-3495	599	29	caralluma	caralluma	PROPN
dti-3495	599	30	europaea	europaea	PROPN
dti-3495	599	31	.	.	PUNCT
dti-3495	600	1	evid	evid	PROPN
dti-3495	600	2	based	base	VERB
dti-3495	600	3	complement	complement	PROPN
dti-3495	600	4	alternat	alternat	NOUN
dti-3495	600	5	med	me	VERB
dti-3495	600	6	.	.	PUNCT
dti-3495	601	1	2018	2018	NUM
dti-3495	601	2	aug	aug	PROPN
dti-3495	601	3	29;2018:9589472	29;2018:9589472	NUM
dti-3495	601	4	.	.	PUNCT
dti-3495	602	1	crossref	crossref	PROPN
dti-3495	602	2	44	44	NUM
dti-3495	602	3	.	.	PUNCT
dti-3495	603	1	jhong	jhong	PROPN
dti-3495	603	2	ch	ch	PROPN
dti-3495	603	3	,	,	PUNCT
dti-3495	603	4	riyaphan	riyaphan	PROPN
dti-3495	603	5	j	j	PROPN
dti-3495	603	6	,	,	PUNCT
dti-3495	603	7	lin	lin	PROPN
dti-3495	603	8	sh	sh	PROPN
dti-3495	603	9	,	,	PUNCT
dti-3495	603	10	et	et	PROPN
dti-3495	603	11	al	al	PROPN
dti-3495	603	12	.	.	PUNCT
dti-3495	603	13	screening	screen	VERB
dti-3495	603	14	alpha	alpha	NOUN
dti-3495	603	15	-	-	PUNCT
dti-3495	603	16	glucosidase	glucosidase	ADJ
dti-3495	603	17	and	and	CCONJ
dti-3495	603	18	alpha	alpha	NOUN
dti-3495	603	19	-	-	PUNCT
dti-3495	603	20	amylase	amylase	NOUN
dti-3495	603	21	inhibitors	inhibitor	NOUN
dti-3495	603	22	from	from	ADP
dti-3495	603	23	natural	natural	ADJ
dti-3495	603	24	compounds	compound	NOUN
dti-3495	603	25	by	by	ADP
dti-3495	603	26	molecular	molecular	ADJ
dti-3495	603	27	docking	docking	NOUN
dti-3495	603	28	in	in	ADP
dti-3495	603	29	silico	silico	NOUN
dti-3495	603	30	.	.	PUNCT
dti-3495	604	1	biofactors	biofactor	NOUN
dti-3495	604	2	.	.	PUNCT
dti-3495	605	1	2015;41(4):242	2015;41(4):242	NOUN
dti-3495	605	2	-	-	SYM
dti-3495	605	3	251	251	NUM
dti-3495	605	4	.	.	PUNCT
dti-3495	606	1	crossref	crossref	PROPN
dti-3495	606	2	pubmed	pubmed	PROPN
dti-3495	606	3	45	45	NUM
dti-3495	606	4	.	.	PUNCT
dti-3495	607	1	castañeda	castañeda	NOUN
dti-3495	607	2	-	-	PUNCT
dti-3495	607	3	pérez	pérez	NOUN
dti-3495	607	4	e	e	NOUN
dti-3495	607	5	,	,	PUNCT
dti-3495	607	6	jiménez	jiménez	PROPN
dti-3495	607	7	-	-	PUNCT
dti-3495	607	8	morales	morale	NOUN
dti-3495	607	9	k	k	PROPN
dti-3495	607	10	,	,	PUNCT
dti-3495	607	11	quintal	quintal	ADJ
dti-3495	607	12	-	-	PUNCT
dti-3495	607	13	novelo	novelo	NOUN
dti-3495	607	14	c	c	NOUN
dti-3495	607	15	,	,	PUNCT
dti-3495	607	16	et	et	PROPN
dti-3495	607	17	al	al	PROPN
dti-3495	607	18	.	.	PUNCT
dti-3495	608	1	enzymatic	enzymatic	ADJ
dti-3495	608	2	protein	protein	NOUN
dti-3495	608	3	hydrolysates	hydrolysate	NOUN
dti-3495	608	4	and	and	CCONJ
dti-3495	608	5	ultrafiltered	ultrafiltered	ADJ
dti-3495	608	6	peptide	peptide	ADJ
dti-3495	608	7	fractions	fraction	NOUN
dti-3495	608	8	from	from	ADP
dti-3495	608	9	cowpea	cowpea	PROPN
dti-3495	608	10	vigna	vigna	PROPN
dti-3495	608	11	unguiculata	unguiculata	PROPN
dti-3495	608	12	l	l	PROPN
dti-3495	608	13	bean	bean	NOUN
dti-3495	608	14	with	with	ADP
dti-3495	608	15	in	in	ADP
dti-3495	608	16	-	-	PUNCT
dti-3495	608	17	vitro	vitro	X
dti-3495	608	18	antidiabetic	antidiabetic	ADJ
dti-3495	608	19	potential	potential	NOUN
dti-3495	608	20	.	.	PUNCT
dti-3495	609	1	j	j	PROPN
dti-3495	609	2	iran	iran	PROPN
dti-3495	609	3	chem	chem	PROPN
dti-3495	609	4	soc	soc	NOUN
dti-3495	609	5	.	.	PUNCT
dti-3495	610	1	2019;16(8):1773	2019;16(8):1773	NUM
dti-3495	610	2	-	-	PUNCT
dti-3495	610	3	1781	1781	NUM
dti-3495	610	4	.	.	PUNCT
dti-3495	611	1	crossref	crossref	PROPN
dti-3495	611	2	46	46	NUM
dti-3495	611	3	.	.	PUNCT
dti-3495	611	4	inhibition	inhibition	NOUN
dti-3495	611	5	of	of	ADP
dti-3495	611	6	the	the	DET
dti-3495	611	7	in	in	ADV
dti-3495	611	8	vitro	vitro	X
dti-3495	611	9	activities	activity	NOUN
dti-3495	611	10	of	of	ADP
dti-3495	611	11	α	α	NOUN
dti-3495	611	12	-	-	NOUN
dti-3495	611	13	amylase	amylase	NOUN
dti-3495	611	14	,	,	PUNCT
dti-3495	611	15	α	α	NOUN
dti-3495	611	16	-	-	PUNCT
dti-3495	611	17	glucosidase	glucosidase	ADJ
dti-3495	611	18	and	and	CCONJ
dti-3495	611	19	pancreatic	pancreatic	ADJ
dti-3495	611	20	lipase	lipase	NOUN
dti-3495	611	21	by	by	ADP
dti-3495	611	22	yellow	yellow	ADJ
dti-3495	611	23	field	field	NOUN
dti-3495	611	24	pea	pea	NOUN
dti-3495	611	25	(	(	PUNCT
dti-3495	611	26	pisum	pisum	NOUN
dti-3495	611	27	sativum	sativum	PROPN
dti-3495	611	28	l.	l.	PROPN
dti-3495	611	29	)	)	PUNCT
dti-3495	611	30	protein	protein	NOUN
dti-3495	611	31	hydrolysates	hydrolysate	NOUN
dti-3495	611	32	.	.	PUNCT
dti-3495	612	1	international	international	PROPN
dti-3495	612	2	j	j	PROPN
dti-3495	612	3	food	food	PROPN
dti-3495	612	4	sci	sci	PROPN
dti-3495	612	5	technol	technol	NOUN
dti-3495	612	6	.	.	PROPN
dti-3495	612	7	2019	2019	NUM
dti-3495	612	8	;	;	PUNCT
dti-3495	612	9	54(6):2021	54(6):2021	NUM
dti-3495	612	10	-	-	SYM
dti-3495	612	11	2034	2034	NUM
dti-3495	612	12	.	.	PUNCT
dti-3495	613	1	crossref	crossref	NOUN
dti-3495	613	2	.	.	PUNCT
dti-3495	614	1	47	47	NUM
dti-3495	614	2	.	.	PUNCT
dti-3495	614	3	oluwafunmilayo	oluwafunmilayo	PROPN
dti-3495	614	4	oo	oo	INTJ
dti-3495	614	5	.	.	PUNCT
dti-3495	615	1	inhibitory	inhibitory	ADJ
dti-3495	615	2	effects	effect	NOUN
dti-3495	615	3	of	of	ADP
dti-3495	615	4	sorghum	sorghum	NOUN
dti-3495	615	5	-	-	PUNCT
dti-3495	615	6	cowpea	cowpea	NOUN
dti-3495	615	7	composite	composite	ADJ
dti-3495	615	8	biscuit	biscuit	NOUN
dti-3495	615	9	on	on	ADP
dti-3495	615	10	starch	starch	NOUN
dti-3495	615	11	-	-	PUNCT
dti-3495	615	12	hydrolysing	hydrolyse	VERB
dti-3495	615	13	enzymes	enzyme	NOUN
dti-3495	615	14	.	.	PUNCT
dti-3495	616	1	kwara	kwara	PROPN
dti-3495	616	2	state	state	PROPN
dti-3495	616	3	university	university	PROPN
dti-3495	616	4	;	;	PUNCT
dti-3495	616	5	2019	2019	NUM
dti-3495	616	6	.	.	PUNCT
dti-3495	617	1	crossref	crossref	PROPN
dti-3495	617	2	48	48	NUM
dti-3495	617	3	.	.	PUNCT
dti-3495	618	1	kim	kim	PROPN
dti-3495	618	2	hm	hm	PROPN
dti-3495	618	3	,	,	PUNCT
dti-3495	618	4	et	et	PROPN
dti-3495	618	5	al	al	PROPN
dti-3495	618	6	.	.	PROPN
dti-3495	618	7	inhibition	inhibition	NOUN
dti-3495	618	8	of	of	ADP
dti-3495	618	9	aldose	aldose	ADJ
dti-3495	618	10	reductase	reductase	NOUN
dti-3495	618	11	from	from	ADP
dti-3495	618	12	rat	rat	NOUN
dti-3495	618	13	lenses	lense	NOUN
dti-3495	618	14	by	by	ADP
dti-3495	618	15	methanol	methanol	NOUN
dti-3495	618	16	extracts	extract	NOUN
dti-3495	618	17	from	from	ADP
dti-3495	618	18	korean	korean	ADJ
dti-3495	618	19	folk	folk	NOUN
dti-3495	618	20	plants	plant	NOUN
dti-3495	618	21	.	.	PUNCT
dti-3495	619	1	nat	nat	PROPN
dti-3495	619	2	prod	prod	PROPN
dti-3495	619	3	sci	sci	PROPN
dti-3495	619	4	.	.	PUNCT
dti-3495	619	5	2010;16(4):285	2010;16(4):285	PROPN
dti-3495	619	6	-	-	SYM
dti-3495	619	7	290	290	NUM
dti-3495	619	8	.	.	PUNCT
dti-3495	620	1	crossref	crossref	PROPN
dti-3495	620	2	49	49	NUM
dti-3495	620	3	.	.	PUNCT
dti-3495	621	1	halder	halder	PROPN
dti-3495	621	2	n	n	PROPN
dti-3495	621	3	,	,	PUNCT
dti-3495	621	4	joshi	joshi	PROPN
dti-3495	621	5	s	s	PROPN
dti-3495	621	6	,	,	PUNCT
dti-3495	621	7	gupta	gupta	PROPN
dti-3495	621	8	sk	sk	PROPN
dti-3495	621	9	.	.	PROPN
dti-3495	621	10	lens	lens	PROPN
dti-3495	621	11	aldose	aldose	PROPN
dti-3495	621	12	reductase	reductase	NOUN
dti-3495	621	13	inhibiting	inhibit	VERB
dti-3495	621	14	potential	potential	NOUN
dti-3495	621	15	of	of	ADP
dti-3495	621	16	some	some	DET
dti-3495	621	17	indigenous	indigenous	ADJ
dti-3495	621	18	plants	plant	NOUN
dti-3495	621	19	.	.	PUNCT
dti-3495	622	1	j	j	PROPN
dti-3495	622	2	ethnopharmacol	ethnopharmacol	PROPN
dti-3495	622	3	.	.	PUNCT
dti-3495	623	1	2003;86(1):113	2003;86(1):113	NUM
dti-3495	623	2	-	-	SYM
dti-3495	623	3	116	116	NUM
dti-3495	623	4	.	.	PUNCT
dti-3495	624	1	crossref	crossref	PROPN
dti-3495	624	2	pubmed	pubmed	PROPN
dti-3495	624	3	50	50	NUM
dti-3495	624	4	.	.	PUNCT
dti-3495	625	1	jope	jope	ADJ
dti-3495	625	2	rs	rs	NOUN
dti-3495	625	3	,	,	PUNCT
dti-3495	625	4	johnson	johnson	PROPN
dti-3495	625	5	gvw	gvw	PROPN
dti-3495	625	6	.	.	PUNCT
dti-3495	626	1	the	the	DET
dti-3495	626	2	glamour	glamour	NOUN
dti-3495	626	3	and	and	CCONJ
dti-3495	626	4	gloom	gloom	NOUN
dti-3495	626	5	of	of	ADP
dti-3495	626	6	glycogen	glycogen	NOUN
dti-3495	626	7	synthase	synthase	NOUN
dti-3495	626	8	kinase-3	kinase-3	PROPN
dti-3495	626	9	.	.	PROPN
dti-3495	626	10	2004;29(2):95	2004;29(2):95	NUM
dti-3495	626	11	-	-	PUNCT
dti-3495	626	12	102	102	NUM
dti-3495	626	13	.	.	PUNCT
dti-3495	627	1	crossref	crossref	PROPN
dti-3495	627	2	51	51	NUM
dti-3495	627	3	.	.	PUNCT
dti-3495	628	1	oshima	oshima	PROPN
dti-3495	628	2	m	m	PROPN
dti-3495	628	3	,	,	PUNCT
dti-3495	628	4	et	et	PROPN
dti-3495	628	5	al	al	PROPN
dti-3495	628	6	.	.	PROPN
dti-3495	628	7	,	,	PUNCT
dti-3495	628	8	suppression	suppression	NOUN
dti-3495	628	9	of	of	ADP
dti-3495	628	10	intestinal	intestinal	ADJ
dti-3495	628	11	polyposis	polyposis	NOUN
dti-3495	628	12	in	in	ADP
dti-3495	628	13	apcδ716	apcδ716	NOUN
dti-3495	628	14	knockout	knockout	NOUN
dti-3495	628	15	mice	mouse	NOUN
dti-3495	628	16	by	by	ADP
dti-3495	628	17	inhibition	inhibition	NOUN
dti-3495	628	18	of	of	ADP
dti-3495	628	19	cyclooxygenase	cyclooxygenase	NOUN
dti-3495	628	20	2(cox-2	2(cox-2	NUM
dti-3495	628	21	)	)	PUNCT
dti-3495	628	22	.	.	PUNCT
dti-3495	629	1	cell;1996;87(5):803	cell;1996;87(5):803	PROPN
dti-3495	629	2	-	-	PUNCT
dti-3495	629	3	809	809	NUM
dti-3495	629	4	.	.	PUNCT
dti-3495	630	1	crossref	crossref	PROPN
dti-3495	630	2	52	52	NUM
dti-3495	630	3	.	.	PUNCT
dti-3495	631	1	shi	shi	PROPN
dti-3495	631	2	h	h	PROPN
dti-3495	631	3	,	,	PUNCT
dti-3495	631	4	et	et	PROPN
dti-3495	631	5	al	al	PROPN
dti-3495	631	6	.	.	PROPN
dti-3495	631	7	,	,	PUNCT
dti-3495	631	8	tlr4	tlr4	NOUN
dti-3495	631	9	links	link	NOUN
dti-3495	631	10	innate	innate	VERB
dti-3495	631	11	immunity	immunity	NOUN
dti-3495	631	12	and	and	CCONJ
dti-3495	631	13	fatty	fatty	NOUN
dti-3495	631	14	acid	acid	NOUN
dti-3495	631	15	–	–	PUNCT
dti-3495	631	16	induced	induce	VERB
dti-3495	631	17	insulin	insulin	NOUN
dti-3495	631	18	resistance	resistance	NOUN
dti-3495	631	19	.	.	PUNCT
dti-3495	632	1	2006;116(11):3015	2006;116(11):3015	NUM
dti-3495	632	2	-	-	SYM
dti-3495	632	3	3025	3025	NUM
dti-3495	632	4	.	.	PUNCT
dti-3495	633	1	crossref	crossref	NOUN
dti-3495	634	1	https://doi.org/10.1007/s11030-023-10684-w	https://doi.org/10.1007/s11030-023-10684-w	X
dti-3495	635	1	https://pubmed.ncbi.nlm.nih.gov/37439907	https://pubmed.ncbi.nlm.nih.gov/37439907	PROPN
dti-3495	635	2	https://doi.org/10.1080/07391102.2020.1719200	https://doi.org/10.1080/07391102.2020.1719200	X
dti-3495	636	1	https://pubmed.ncbi.nlm.nih.gov/31965918	https://pubmed.ncbi.nlm.nih.gov/31965918	PROPN
dti-3495	636	2	https://doi.org/10.1002/pep2.24391	https://doi.org/10.1002/pep2.24391	PROPN
dti-3495	636	3	https://doi.org/10.2174/187152809787582561	https://doi.org/10.2174/187152809787582561	NOUN
dti-3495	636	4	https://doi.org/10.13040/ijpsr.0975-8232	https://doi.org/10.13040/ijpsr.0975-8232	PROPN
dti-3495	637	1	https://doi.org/10.1155/2018/9589472	https://doi.org/10.1155/2018/9589472	PROPN
dti-3495	637	2	https://doi.org/10.1002/biof.1219	https://doi.org/10.1002/biof.1219	NOUN
dti-3495	637	3	https://pubmed.ncbi.nlm.nih.gov/26154585	https://pubmed.ncbi.nlm.nih.gov/26154585	VERB
dti-3495	637	4	https://doi.org/10.1007/s13738-019-01651-0	https://doi.org/10.1007/s13738-019-01651-0	ADJ
dti-3495	637	5	https://doi.org/10.1111/ijfs.14087	https://doi.org/10.1111/ijfs.14087	NOUN
dti-3495	637	6	https://doi.org/10.35219/foodtechnology.2021.1.06	https://doi.org/10.35219/foodtechnology.2021.1.06	X
dti-3495	637	7	https://doi.org/10.7744/cnujas.2012.39.2.169	https://doi.org/10.7744/cnujas.2012.39.2.169	PROPN
dti-3495	637	8	https://doi.org/10.1016/s0378-8741(03)00052-7	https://doi.org/10.1016/s0378-8741(03)00052-7	PROPN
dti-3495	638	1	https://pubmed.ncbi.nlm.nih.gov/12686449	https://pubmed.ncbi.nlm.nih.gov/12686449	PROPN
dti-3495	638	2	https://doi.org/10.1016/j.tibs.2003.12.004	https://doi.org/10.1016/j.tibs.2003.12.004	PROPN
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