E- Global Congress Hosted online from Dubai, U. A. E., E - Conference. Date: 29th September 2024 Website: https://eglobalcongress.com/index.php/egc ISSN (E): 2836-3612 12 | P a g e CORRELATION OF CYTOKINE LEVELS IN CHILDREN WITH JUVENILE RHEUMATOID ARTHRITIS (JRA) AGED 7 TO 14 YEARS Sadikova A. M. M. R. Ruzibakiyeva Tashkent Pediatric Medical Institute Relevance: Juvenile rheumatoid arthritis (JRA) is one of the most common chronic inflammatory joint diseases in children, leading to significant immune system changes. Cytokines play a key role in the pathogenesis of JRA, and their levels may serve as prognostic markers for disease activity. Objective: To assess the levels of IL-8, IL-17A, and interferon-γ (IFNγ) in children with JRA aged 7 to 14 years, with both seropositive and seronegative forms of the disease. Materials and Methods: Ninety-three children with JRA were divided into two age groups. Cytokine levels were quantitatively assessed using enzyme-linked immunosorbent assay (ELISA). Results and Discussion: IL-8 levels were significantly elevated in children with the seropositive form of JRA (20,9±3,12 pg/mL), which is 1,85 times higher than in the control group. IL- 17A was also significantly elevated in the seropositive group (30,25±4,61 pg/mL), 2,88 times higher than in the control group. Both groups exhibited a significant reduction in IFNγ production, particularly in the seropositive group, suggesting impaired antiviral defense and activation of inflammatory pathways. Conclusion: The elevated levels of pro-inflammatory cytokines IL-8 and IL-17A, coupled with reduced IFNγ levels, suggest that children with JRA, especially those with the seropositive form, experience heightened inflammatory responses. These findings highlight the importance of cytokine profiling for understanding disease severity and guiding therapeutic interventions. https://eglobalcongress.com/index.php/egc E- Global Congress Hosted online from Dubai, U. A. E., E - Conference. Date: 29th September 2024 Website: https://eglobalcongress.com/index.php/egc ISSN (E): 2836-3612 13 | P a g e Reference list: 1. Abramkin AA, Lisitsyna TA, Veltishchev DYu, Seravina OF, Kovalevskaya OB, Nasonov EL. The influence of synthetic disease-modifying anti- inflammatory drugs, genetically engineered biological agents and psychopharmacological therapy on the dynamics of mental disorders in patients with rheumatoid arthritis // Scientific and practical rheumatology. 2017—No. 55— Vol. 4 —P. 393—402. 2. Avdeeva AS, Artyukhov AS, Dashinimaev EB, Cherkasova MV, Nasonov EL. Dynamics of cytokine profile parameters against the background of the use of a biosimilar of rituximab (Acellbia, BIOCAD) and the original drug (MabThera, F. Hoffmann-La Roche Ltd., Switzerland) in the treatment of rheumatoid arthritis // Scientific and practical rheumatology. 2019—No. 57— Vol. 1 —P. 46—55. 3. Avdeeva AS, Cherkasova MV, Kusevich DA, Rybakova VV, Nasonov EL. Immunological effects of a biosimilar of rituximab (Acellbia, BIOCAD) in patients with rheumatoid arthritis // Scientific and practical rheumatology. 2018— No. 56— Vol. 5 —P. 556—563. 4. Beketova TV, Arsenyev EV. Interleukin 5 — a new target for the therapy of eosinophilic granulomatosis with polyangiitis // Scientific and practical rheumatology. 2020—№ 58— Vol. 3 —P. 321—329. 5. Beketova TV, Blank LM, Lila AM. COVID-19 in a patient with ANCA- associated systemic vasculitis receiving anti-B-cell therapy with rituximab // Scientific and practical rheumatology. 2020—№ 58— Vol. 4 —P. 456—462. https://eglobalcongress.com/index.php/egc