id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
ecletica-1273	Milagre, Cintia Duarte de Freitas; do Amaral, Bruno Sergio; Batista Junior, João Marcos; Vilela, Adriana Ferreira Lopes; Cardoso, Carmen Lúcia; Milagre, Humberto Marcio Santos	Levetiracetam analogs: chemoenzymatic synthesis, absolute configuration assignment and evaluation of cholinesterase inhibitory activities	2022	19	.pdf	application/pdf	12721	606	53	Although NHase is largely employed for the industrial production of acrylamide and nicotinamide (Jiao et al., 2020; Wang, 2015), the application of the wild-type enzyme can be limited by its narrow substrate specificity, low enantioselectivity, unsatisfactory catalytic activity, inhibition at a high concentration of substrate and low thermostability (Bhalla et al., 2018; Gong et al., 2017; Prasad and Bhalla, 2010; Supreetha et al., 2019; Wang, 2009). https://revista.iq.unesp.br/index.php/ecletica https://doi.org/10.26850/1678-4618eqj.v47.2.2022.p17-35 mailto:cintia.milagre@unesp.br https://orcid.org/0000-0001-5627-8616 https://orcid.org/0000-0001-6194-2390 https://orcid.org/0000-0002-0267-2631 https://orcid.org/0000-0001-9860-9866 https://orcid.org/0000-0001-6239-6651 https://orcid.org/0000-0001-9468-1166 Original article revista.iq.unesp.br 18 Eclética Química Journal, vol. 47, n. 2, 2022, 17-35 ISSN: 1678-4618 DOI: 10.26850/1678-4618eqj.v47.2.2022.p17-35 1. Introduction N-heterocycles are a key structural unit, which are vastly distributed among natural products and biomolecules, such as DNA and RNA, and correspond to more than 70% of all pharmaceuticals and agrochemicals (Liu et al., 2019; Saini et al., 2013).	cache/ecletica-1273.pdf	txt/ecletica-1273.txt