id	sid	tid	token	lemma	pos
ecletica-1173	1	1	review	review	NOUN
ecletica-1173	1	2	article	article	NOUN
ecletica-1173	1	3	iq.unesp.br/ecletica	iq.unesp.br/ecletica	PROPN
ecletica-1173	1	4	|	|	ADV
ecletica-1173	1	5	vol	vol	NOUN
ecletica-1173	1	6	.	.	PUNCT
ecletica-1173	1	7	46	46	NUM
ecletica-1173	2	1	|	|	ADV
ecletica-1173	2	2	n.	n.	NOUN
ecletica-1173	2	3	3	3	NUM
ecletica-1173	3	1	|	|	ADV
ecletica-1173	3	2	2021	2021	NUM
ecletica-1173	3	3	|	|	ADV
ecletica-1173	3	4	17	17	NUM
ecletica-1173	3	5	eclética	eclética	PROPN
ecletica-1173	3	6	química	química	PROPN
ecletica-1173	3	7	journal	journal	PROPN
ecletica-1173	3	8	,	,	PUNCT
ecletica-1173	3	9	vol	vol	NOUN
ecletica-1173	3	10	.	.	PROPN
ecletica-1173	3	11	46	46	NUM
ecletica-1173	3	12	,	,	PUNCT
ecletica-1173	3	13	n.	n.	NOUN
ecletica-1173	3	14	3	3	NUM
ecletica-1173	3	15	,	,	PUNCT
ecletica-1173	3	16	2021	2021	NUM
ecletica-1173	3	17	,	,	PUNCT
ecletica-1173	3	18	17	17	NUM
ecletica-1173	3	19	-	-	SYM
ecletica-1173	3	20	32	32	NUM
ecletica-1173	3	21	issn	issn	NOUN
ecletica-1173	3	22	:	:	PUNCT
ecletica-1173	3	23	1678	1678	NUM
ecletica-1173	3	24	-	-	SYM
ecletica-1173	3	25	4618	4618	NUM
ecletica-1173	3	26	doi	doi	NOUN
ecletica-1173	3	27	:	:	PUNCT
ecletica-1173	3	28	10.26850/1678	10.26850/1678	NUM
ecletica-1173	3	29	-	-	SYM
ecletica-1173	3	30	4618eqj.v46.3.2021.p17	4618eqj.v46.3.2021.p17	NOUN
ecletica-1173	3	31	-	-	NOUN
ecletica-1173	3	32	32	32	NUM
ecletica-1173	3	33	a	a	DET
ecletica-1173	3	34	criticism	criticism	NOUN
ecletica-1173	3	35	of	of	ADP
ecletica-1173	3	36	the	the	DET
ecletica-1173	3	37	reductionist	reductionist	NOUN
ecletica-1173	3	38	and	and	CCONJ
ecletica-1173	3	39	holistic	holistic	ADJ
ecletica-1173	3	40	vision	vision	NOUN
ecletica-1173	3	41	in	in	ADP
ecletica-1173	3	42	the	the	DET
ecletica-1173	3	43	planning	planning	NOUN
ecletica-1173	3	44	of	of	ADP
ecletica-1173	3	45	drugs	drug	NOUN
ecletica-1173	3	46	in	in	ADP
ecletica-1173	3	47	biological	biological	ADJ
ecletica-1173	3	48	,	,	PUNCT
ecletica-1173	3	49	chemical	chemical	NOUN
ecletica-1173	3	50	and	and	CCONJ
ecletica-1173	3	51	physical	physical	ADJ
ecletica-1173	3	52	level	level	NOUN
ecletica-1173	3	53	daniel	daniel	PROPN
ecletica-1173	3	54	augusto	augusto	PROPN
ecletica-1173	3	55	barra	barra	PROPN
ecletica-1173	3	56	de	de	X
ecletica-1173	3	57	oliveira1	oliveira1	PROPN
ecletica-1173	3	58	+	+	CCONJ
ecletica-1173	3	59	,	,	PUNCT
ecletica-1173	3	60	edenilson	edenilson	NOUN
ecletica-1173	3	61	dos	do	VERB
ecletica-1173	3	62	santos	santos	PROPN
ecletica-1173	3	63	niculau1	niculau1	NOUN
ecletica-1173	3	64	1	1	NUM
ecletica-1173	3	65	.	.	PUNCT
ecletica-1173	3	66	federal	federal	PROPN
ecletica-1173	3	67	university	university	PROPN
ecletica-1173	3	68	of	of	ADP
ecletica-1173	3	69	tocantins	tocantins	PROPN
ecletica-1173	3	70	,	,	PUNCT
ecletica-1173	3	71	integrated	integrate	VERB
ecletica-1173	3	72	sciences	science	NOUN
ecletica-1173	3	73	center	center	NOUN
ecletica-1173	3	74	,	,	PUNCT
ecletica-1173	3	75	araguaína	araguaína	PROPN
ecletica-1173	3	76	,	,	PUNCT
ecletica-1173	3	77	brazil	brazil	PROPN
ecletica-1173	3	78	.	.	PUNCT
ecletica-1173	4	1	+	+	PUNCT
ecletica-1173	4	2	corresponding	correspond	VERB
ecletica-1173	4	3	author	author	NOUN
ecletica-1173	4	4	:	:	PUNCT
ecletica-1173	4	5	daniel	daniel	PROPN
ecletica-1173	4	6	augusto	augusto	PROPN
ecletica-1173	4	7	barra	barra	PROPN
ecletica-1173	4	8	de	de	PROPN
ecletica-1173	4	9	oliveira	oliveira	PROPN
ecletica-1173	4	10	,	,	PUNCT
ecletica-1173	4	11	phone	phone	NOUN
ecletica-1173	4	12	:	:	PUNCT
ecletica-1173	4	13	+55	+55	PROPN
ecletica-1173	4	14	(	(	PUNCT
ecletica-1173	4	15	63	63	NUM
ecletica-1173	4	16	)	)	PUNCT
ecletica-1173	4	17	99200	99200	NUM
ecletica-1173	4	18	-	-	SYM
ecletica-1173	4	19	7791	7791	NUM
ecletica-1173	4	20	,	,	PUNCT
ecletica-1173	4	21	email	email	NOUN
ecletica-1173	4	22	address	address	NOUN
ecletica-1173	4	23	:	:	PUNCT
ecletica-1173	4	24	danielchem@uft.edu.br	danielchem@uft.edu.br	ADJ
ecletica-1173	4	25	article	article	NOUN
ecletica-1173	4	26	info	info	NOUN
ecletica-1173	4	27	article	article	NOUN
ecletica-1173	4	28	history	history	NOUN
ecletica-1173	4	29	:	:	PUNCT
ecletica-1173	4	30	received	receive	VERB
ecletica-1173	4	31	:	:	PUNCT
ecletica-1173	4	32	june	june	PROPN
ecletica-1173	4	33	12	12	NUM
ecletica-1173	4	34	,	,	PUNCT
ecletica-1173	4	35	2020	2020	NUM
ecletica-1173	4	36	accepted	accept	VERB
ecletica-1173	4	37	:	:	PUNCT
ecletica-1173	4	38	may	may	AUX
ecletica-1173	4	39	19	19	NUM
ecletica-1173	4	40	,	,	PUNCT
ecletica-1173	4	41	2021	2021	NUM
ecletica-1173	4	42	published	publish	VERB
ecletica-1173	4	43	:	:	PUNCT
ecletica-1173	4	44	july	july	PROPN
ecletica-1173	4	45	01	01	NUM
ecletica-1173	4	46	,	,	PUNCT
ecletica-1173	4	47	2021	2021	NUM
ecletica-1173	4	48	section	section	NOUN
ecletica-1173	4	49	editor	editor	NOUN
ecletica-1173	4	50	:	:	PUNCT
ecletica-1173	4	51	assis	assis	PROPN
ecletica-1173	4	52	vicente	vicente	PROPN
ecletica-1173	4	53	benedetti	benedetti	PROPN
ecletica-1173	4	54	keywords	keyword	NOUN
ecletica-1173	4	55	1	1	NUM
ecletica-1173	4	56	.	.	PUNCT
ecletica-1173	4	57	drug	drug	NOUN
ecletica-1173	4	58	design	design	NOUN
ecletica-1173	4	59	2	2	NUM
ecletica-1173	4	60	.	.	PUNCT
ecletica-1173	4	61	reductionism	reductionism	NOUN
ecletica-1173	4	62	3	3	NUM
ecletica-1173	4	63	.	.	PUNCT
ecletica-1173	4	64	holism	holism	NOUN
ecletica-1173	4	65	4	4	NUM
ecletica-1173	4	66	.	.	PUNCT
ecletica-1173	4	67	organicism	organicism	NOUN
ecletica-1173	4	68	5	5	NUM
ecletica-1173	4	69	.	.	PUNCT
ecletica-1173	4	70	systems	system	NOUN
ecletica-1173	4	71	biology	biology	NOUN
ecletica-1173	4	72	contents	content	VERB
ecletica-1173	4	73	1	1	NUM
ecletica-1173	4	74	.	.	PUNCT
ecletica-1173	4	75	introduction	introduction	NOUN
ecletica-1173	4	76	2	2	NUM
ecletica-1173	4	77	.	.	PUNCT
ecletica-1173	4	78	methodology	methodology	NOUN
ecletica-1173	4	79	3	3	NUM
ecletica-1173	4	80	.	.	PUNCT
ecletica-1173	4	81	drug	drug	NOUN
ecletica-1173	4	82	design	design	NOUN
ecletica-1173	4	83	4	4	NUM
ecletica-1173	4	84	.	.	PUNCT
ecletica-1173	5	1	the	the	DET
ecletica-1173	5	2	origin	origin	NOUN
ecletica-1173	5	3	of	of	ADP
ecletica-1173	5	4	biological	biological	ADJ
ecletica-1173	5	5	reductionism	reductionism	NOUN
ecletica-1173	5	6	5	5	NUM
ecletica-1173	5	7	.	.	PUNCT
ecletica-1173	5	8	chemical	chemical	ADJ
ecletica-1173	5	9	reductionism	reductionism	NOUN
ecletica-1173	5	10	6	6	NUM
ecletica-1173	5	11	.	.	PUNCT
ecletica-1173	6	1	physical	physical	ADJ
ecletica-1173	6	2	reductionism	reductionism	NOUN
ecletica-1173	6	3	7	7	NUM
ecletica-1173	6	4	.	.	PUNCT
ecletica-1173	7	1	the	the	DET
ecletica-1173	7	2	problem	problem	NOUN
ecletica-1173	7	3	in	in	ADP
ecletica-1173	7	4	design	design	NOUN
ecletica-1173	7	5	of	of	ADP
ecletica-1173	7	6	new	new	ADJ
ecletica-1173	7	7	drugs	drug	NOUN
ecletica-1173	7	8	8	8	NUM
ecletica-1173	7	9	.	.	X
ecletica-1173	7	10	organicism	organicism	NOUN
ecletica-1173	7	11	as	as	ADP
ecletica-1173	7	12	a	a	DET
ecletica-1173	7	13	counterproposal	counterproposal	NOUN
ecletica-1173	7	14	in	in	ADP
ecletica-1173	7	15	cancer	cancer	NOUN
ecletica-1173	7	16	treatment	treatment	NOUN
ecletica-1173	7	17	8.1	8.1	NUM
ecletica-1173	7	18	systems	system	NOUN
ecletica-1173	7	19	biology	biology	NOUN
ecletica-1173	7	20	8.2	8.2	NUM
ecletica-1173	7	21	predicting	predict	VERB
ecletica-1173	7	22	drug	drug	NOUN
ecletica-1173	7	23	-	-	PUNCT
ecletica-1173	7	24	target	target	NOUN
ecletica-1173	7	25	interactions	interaction	NOUN
ecletica-1173	7	26	(	(	PUNCT
ecletica-1173	7	27	dti	dti	PROPN
ecletica-1173	7	28	)	)	PUNCT
ecletica-1173	7	29	9	9	NUM
ecletica-1173	7	30	.	.	X
ecletica-1173	7	31	concluding	conclude	VERB
ecletica-1173	7	32	remarks	remark	NOUN
ecletica-1173	7	33	abstract	abstract	ADJ
ecletica-1173	7	34	:	:	PUNCT
ecletica-1173	7	35	in	in	ADP
ecletica-1173	7	36	this	this	DET
ecletica-1173	7	37	work	work	NOUN
ecletica-1173	7	38	,	,	PUNCT
ecletica-1173	7	39	two	two	NUM
ecletica-1173	7	40	philosophical	philosophical	ADJ
ecletica-1173	7	41	premises	premise	NOUN
ecletica-1173	7	42	of	of	ADP
ecletica-1173	7	43	science	science	NOUN
ecletica-1173	7	44	applied	apply	VERB
ecletica-1173	7	45	in	in	ADP
ecletica-1173	7	46	the	the	DET
ecletica-1173	7	47	understanding	understanding	NOUN
ecletica-1173	7	48	of	of	ADP
ecletica-1173	7	49	diseases	disease	NOUN
ecletica-1173	7	50	and	and	CCONJ
ecletica-1173	7	51	in	in	ADP
ecletica-1173	7	52	the	the	DET
ecletica-1173	7	53	planning	planning	NOUN
ecletica-1173	7	54	of	of	ADP
ecletica-1173	7	55	drugs	drug	NOUN
ecletica-1173	7	56	were	be	AUX
ecletica-1173	7	57	studied	study	VERB
ecletica-1173	7	58	.	.	PUNCT
ecletica-1173	8	1	the	the	DET
ecletica-1173	8	2	first	first	ADJ
ecletica-1173	8	3	premise	premise	NOUN
ecletica-1173	8	4	is	be	AUX
ecletica-1173	8	5	reductionism	reductionism	NOUN
ecletica-1173	8	6	.	.	PUNCT
ecletica-1173	9	1	this	this	DET
ecletica-1173	9	2	idea	idea	NOUN
ecletica-1173	9	3	is	be	AUX
ecletica-1173	9	4	present	present	ADJ
ecletica-1173	9	5	in	in	ADP
ecletica-1173	9	6	modern	modern	ADJ
ecletica-1173	9	7	science	science	NOUN
ecletica-1173	9	8	when	when	SCONJ
ecletica-1173	9	9	a	a	DET
ecletica-1173	9	10	problem	problem	NOUN
ecletica-1173	9	11	can	can	AUX
ecletica-1173	9	12	be	be	AUX
ecletica-1173	9	13	reduced	reduce	VERB
ecletica-1173	9	14	to	to	ADP
ecletica-1173	9	15	the	the	DET
ecletica-1173	9	16	sum	sum	NOUN
ecletica-1173	9	17	of	of	ADP
ecletica-1173	9	18	its	its	PRON
ecletica-1173	9	19	individual	individual	ADJ
ecletica-1173	9	20	parts	part	NOUN
ecletica-1173	9	21	.	.	PUNCT
ecletica-1173	10	1	diseases	disease	NOUN
ecletica-1173	10	2	can	can	AUX
ecletica-1173	10	3	be	be	AUX
ecletica-1173	10	4	understood	understand	VERB
ecletica-1173	10	5	as	as	ADP
ecletica-1173	10	6	the	the	DET
ecletica-1173	10	7	metabolic	metabolic	NOUN
ecletica-1173	10	8	action	action	NOUN
ecletica-1173	10	9	of	of	ADP
ecletica-1173	10	10	few	few	ADJ
ecletica-1173	10	11	enzymes	enzyme	NOUN
ecletica-1173	10	12	.	.	PUNCT
ecletica-1173	11	1	drugs	drug	NOUN
ecletica-1173	11	2	can	can	AUX
ecletica-1173	11	3	be	be	AUX
ecletica-1173	11	4	planned	plan	VERB
ecletica-1173	11	5	through	through	ADP
ecletica-1173	11	6	the	the	DET
ecletica-1173	11	7	mimicry	mimicry	NOUN
ecletica-1173	11	8	of	of	ADP
ecletica-1173	11	9	a	a	DET
ecletica-1173	11	10	specific	specific	ADJ
ecletica-1173	11	11	enzymatic	enzymatic	ADJ
ecletica-1173	11	12	substrate	substrate	NOUN
ecletica-1173	11	13	.	.	PUNCT
ecletica-1173	12	1	biological	biological	ADJ
ecletica-1173	12	2	molecules	molecule	NOUN
ecletica-1173	12	3	can	can	AUX
ecletica-1173	12	4	be	be	AUX
ecletica-1173	12	5	explained	explain	VERB
ecletica-1173	12	6	by	by	ADP
ecletica-1173	12	7	the	the	DET
ecletica-1173	12	8	quantum	quantum	NOUN
ecletica-1173	12	9	theory	theory	NOUN
ecletica-1173	12	10	applied	apply	VERB
ecletica-1173	12	11	to	to	ADP
ecletica-1173	12	12	atoms	atom	NOUN
ecletica-1173	12	13	and	and	CCONJ
ecletica-1173	12	14	molecules	molecule	NOUN
ecletica-1173	12	15	.	.	PUNCT
ecletica-1173	13	1	this	this	DET
ecletica-1173	13	2	idea	idea	NOUN
ecletica-1173	13	3	has	have	AUX
ecletica-1173	13	4	been	be	AUX
ecletica-1173	13	5	the	the	DET
ecletica-1173	13	6	predominant	predominant	ADJ
ecletica-1173	13	7	way	way	NOUN
ecletica-1173	13	8	in	in	ADP
ecletica-1173	13	9	modern	modern	ADJ
ecletica-1173	13	10	science	science	NOUN
ecletica-1173	13	11	.	.	PUNCT
ecletica-1173	14	1	on	on	ADP
ecletica-1173	14	2	the	the	DET
ecletica-1173	14	3	other	other	ADJ
ecletica-1173	14	4	hand	hand	NOUN
ecletica-1173	14	5	,	,	PUNCT
ecletica-1173	14	6	there	there	PRON
ecletica-1173	14	7	is	be	VERB
ecletica-1173	14	8	a	a	DET
ecletica-1173	14	9	holistic	holistic	ADJ
ecletica-1173	14	10	view	view	NOUN
ecletica-1173	14	11	of	of	ADP
ecletica-1173	14	12	the	the	DET
ecletica-1173	14	13	phenomenon	phenomenon	NOUN
ecletica-1173	14	14	.	.	PUNCT
ecletica-1173	15	1	in	in	ADP
ecletica-1173	15	2	this	this	DET
ecletica-1173	15	3	holistic	holistic	ADJ
ecletica-1173	15	4	view	view	NOUN
ecletica-1173	15	5	,	,	PUNCT
ecletica-1173	15	6	the	the	DET
ecletica-1173	15	7	phenomenon	phenomenon	NOUN
ecletica-1173	15	8	must	must	AUX
ecletica-1173	15	9	be	be	AUX
ecletica-1173	15	10	understood	understand	VERB
ecletica-1173	15	11	as	as	ADP
ecletica-1173	15	12	the	the	DET
ecletica-1173	15	13	whole	whole	NOUN
ecletica-1173	15	14	.	.	PUNCT
ecletica-1173	16	1	drug	drug	NOUN
ecletica-1173	16	2	design	design	NOUN
ecletica-1173	16	3	should	should	AUX
ecletica-1173	16	4	be	be	AUX
ecletica-1173	16	5	thought	think	VERB
ecletica-1173	16	6	from	from	ADP
ecletica-1173	16	7	a	a	DET
ecletica-1173	16	8	network	network	NOUN
ecletica-1173	16	9	of	of	ADP
ecletica-1173	16	10	proteins	protein	NOUN
ecletica-1173	16	11	,	,	PUNCT
ecletica-1173	16	12	not	not	PART
ecletica-1173	16	13	just	just	ADV
ecletica-1173	16	14	from	from	ADP
ecletica-1173	16	15	a	a	DET
ecletica-1173	16	16	single	single	ADJ
ecletica-1173	16	17	enzymatic	enzymatic	ADJ
ecletica-1173	16	18	target	target	NOUN
ecletica-1173	16	19	.	.	PUNCT
ecletica-1173	17	1	there	there	PRON
ecletica-1173	17	2	is	be	VERB
ecletica-1173	17	3	in	in	ADP
ecletica-1173	17	4	fact	fact	NOUN
ecletica-1173	17	5	a	a	DET
ecletica-1173	17	6	slight	slight	ADJ
ecletica-1173	17	7	advantage	advantage	NOUN
ecletica-1173	17	8	in	in	ADP
ecletica-1173	17	9	the	the	DET
ecletica-1173	17	10	reductionist	reductionist	ADJ
ecletica-1173	17	11	method	method	NOUN
ecletica-1173	17	12	,	,	PUNCT
ecletica-1173	17	13	because	because	SCONJ
ecletica-1173	17	14	this	this	DET
ecletica-1173	17	15	philosophical	philosophical	ADJ
ecletica-1173	17	16	view	view	NOUN
ecletica-1173	17	17	simplifies	simplify	VERB
ecletica-1173	17	18	the	the	DET
ecletica-1173	17	19	problem	problem	NOUN
ecletica-1173	17	20	.	.	PUNCT
ecletica-1173	18	1	today	today	NOUN
ecletica-1173	18	2	,	,	PUNCT
ecletica-1173	18	3	a	a	DET
ecletica-1173	18	4	holistic	holistic	ADJ
ecletica-1173	18	5	view	view	NOUN
ecletica-1173	18	6	combined	combine	VERB
ecletica-1173	18	7	with	with	ADP
ecletica-1173	18	8	methodological	methodological	ADJ
ecletica-1173	18	9	reductionism	reductionism	NOUN
ecletica-1173	18	10	is	be	AUX
ecletica-1173	18	11	used	use	VERB
ecletica-1173	18	12	to	to	PART
ecletica-1173	18	13	develop	develop	VERB
ecletica-1173	18	14	new	new	ADJ
ecletica-1173	18	15	potential	potential	ADJ
ecletica-1173	18	16	drugs	drug	NOUN
ecletica-1173	18	17	.	.	PUNCT
ecletica-1173	19	1	http://revista.iq.unesp.br/ojs/index.php/ecletica/index	http://revista.iq.unesp.br/ojs/index.php/ecletica/index	NOUN
ecletica-1173	19	2	https://doi.org/10.26850/1678-4618eqj.v46.3.2021.p17-32	https://doi.org/10.26850/1678-4618eqj.v46.3.2021.p17-32	PROPN
ecletica-1173	19	3	mailto:danielchem@uft.edu.br	mailto:danielchem@uft.edu.br	VERB
ecletica-1173	19	4	https://orcid.org/0000-0002-7300-9052	https://orcid.org/0000-0002-7300-9052	PROPN
ecletica-1173	20	1	https://orcid.org/0000-0003-0326-5795	https://orcid.org/0000-0003-0326-5795	PROPN
ecletica-1173	20	2	review	review	NOUN
ecletica-1173	20	3	article	article	NOUN
ecletica-1173	20	4	iq.unesp.br/ecletica	iq.unesp.br/ecletica	PROPN
ecletica-1173	20	5	18	18	NUM
ecletica-1173	20	6	eclética	eclética	PROPN
ecletica-1173	20	7	química	química	PROPN
ecletica-1173	20	8	journal	journal	PROPN
ecletica-1173	20	9	,	,	PUNCT
ecletica-1173	20	10	vol	vol	NOUN
ecletica-1173	20	11	.	.	PROPN
ecletica-1173	20	12	46	46	NUM
ecletica-1173	20	13	,	,	PUNCT
ecletica-1173	20	14	n.	n.	NOUN
ecletica-1173	20	15	3	3	NUM
ecletica-1173	20	16	,	,	PUNCT
ecletica-1173	20	17	2021	2021	NUM
ecletica-1173	20	18	,	,	PUNCT
ecletica-1173	20	19	17	17	NUM
ecletica-1173	20	20	-	-	SYM
ecletica-1173	20	21	32	32	NUM
ecletica-1173	20	22	issn	issn	NOUN
ecletica-1173	20	23	:	:	PUNCT
ecletica-1173	20	24	1678	1678	NUM
ecletica-1173	20	25	-	-	SYM
ecletica-1173	20	26	4618	4618	NUM
ecletica-1173	20	27	doi	doi	NOUN
ecletica-1173	20	28	:	:	PUNCT
ecletica-1173	20	29	10.26850/1678	10.26850/1678	NUM
ecletica-1173	20	30	-	-	SYM
ecletica-1173	20	31	4618eqj.v46.3.2021.p17	4618eqj.v46.3.2021.p17	NOUN
ecletica-1173	20	32	-	-	PUNCT
ecletica-1173	20	33	32	32	NUM
ecletica-1173	20	34	1	1	NUM
ecletica-1173	20	35	.	.	PUNCT
ecletica-1173	21	1	introduction	introduction	NOUN
ecletica-1173	21	2	discussion	discussion	NOUN
ecletica-1173	21	3	between	between	ADP
ecletica-1173	21	4	reductionist	reductionist	NOUN
ecletica-1173	21	5	and	and	CCONJ
ecletica-1173	21	6	holistic	holistic	ADJ
ecletica-1173	21	7	methods	method	NOUN
ecletica-1173	21	8	have	have	AUX
ecletica-1173	21	9	been	be	AUX
ecletica-1173	21	10	used	use	VERB
ecletica-1173	21	11	to	to	PART
ecletica-1173	21	12	understand	understand	VERB
ecletica-1173	21	13	the	the	DET
ecletica-1173	21	14	nature	nature	NOUN
ecletica-1173	21	15	of	of	ADP
ecletica-1173	21	16	matter	matter	NOUN
ecletica-1173	21	17	.	.	PUNCT
ecletica-1173	22	1	democritus	democritus	PROPN
ecletica-1173	22	2	and	and	CCONJ
ecletica-1173	22	3	leucippus	leucippus	PROPN
ecletica-1173	22	4	,	,	PUNCT
ecletica-1173	22	5	the	the	DET
ecletica-1173	22	6	“	"	PUNCT
ecletica-1173	22	7	creators	creator	NOUN
ecletica-1173	22	8	”	"	PUNCT
ecletica-1173	22	9	of	of	ADP
ecletica-1173	22	10	the	the	DET
ecletica-1173	22	11	atom	atom	NOUN
ecletica-1173	22	12	idea	idea	NOUN
ecletica-1173	22	13	,	,	PUNCT
ecletica-1173	22	14	were	be	AUX
ecletica-1173	22	15	the	the	DET
ecletica-1173	22	16	first	first	ADJ
ecletica-1173	22	17	to	to	PART
ecletica-1173	22	18	establish	establish	VERB
ecletica-1173	22	19	a	a	DET
ecletica-1173	22	20	reductionist	reductionist	ADJ
ecletica-1173	22	21	explanation	explanation	NOUN
ecletica-1173	22	22	of	of	ADP
ecletica-1173	22	23	matter	matter	NOUN
ecletica-1173	22	24	assuming	assume	VERB
ecletica-1173	22	25	the	the	DET
ecletica-1173	22	26	existence	existence	NOUN
ecletica-1173	22	27	of	of	ADP
ecletica-1173	22	28	atoms	atom	NOUN
ecletica-1173	22	29	.	.	PUNCT
ecletica-1173	23	1	on	on	ADP
ecletica-1173	23	2	the	the	DET
ecletica-1173	23	3	other	other	ADJ
ecletica-1173	23	4	hand	hand	NOUN
ecletica-1173	23	5	,	,	PUNCT
ecletica-1173	23	6	aristotle	aristotle	PROPN
ecletica-1173	23	7	admitted	admit	VERB
ecletica-1173	23	8	holistic	holistic	ADJ
ecletica-1173	23	9	explanations	explanation	NOUN
ecletica-1173	23	10	.	.	PUNCT
ecletica-1173	24	1	there	there	PRON
ecletica-1173	24	2	are	be	VERB
ecletica-1173	24	3	three	three	NUM
ecletica-1173	24	4	types	type	NOUN
ecletica-1173	24	5	of	of	ADP
ecletica-1173	24	6	reductionism	reductionism	NOUN
ecletica-1173	24	7	.	.	PUNCT
ecletica-1173	25	1	ontological	ontological	ADJ
ecletica-1173	25	2	reductionism	reductionism	NOUN
ecletica-1173	25	3	is	be	AUX
ecletica-1173	25	4	justified	justify	VERB
ecletica-1173	25	5	on	on	ADP
ecletica-1173	25	6	the	the	DET
ecletica-1173	25	7	assumption	assumption	NOUN
ecletica-1173	25	8	that	that	SCONJ
ecletica-1173	25	9	behavior	behavior	NOUN
ecletica-1173	25	10	of	of	ADP
ecletica-1173	25	11	the	the	DET
ecletica-1173	25	12	whole	whole	NOUN
ecletica-1173	25	13	can	can	AUX
ecletica-1173	25	14	be	be	AUX
ecletica-1173	25	15	explained	explain	VERB
ecletica-1173	25	16	by	by	ADP
ecletica-1173	25	17	the	the	DET
ecletica-1173	25	18	sum	sum	NOUN
ecletica-1173	25	19	of	of	ADP
ecletica-1173	25	20	the	the	DET
ecletica-1173	25	21	individual	individual	ADJ
ecletica-1173	25	22	properties	property	NOUN
ecletica-1173	25	23	of	of	ADP
ecletica-1173	25	24	the	the	DET
ecletica-1173	25	25	components	component	NOUN
ecletica-1173	25	26	.	.	PUNCT
ecletica-1173	26	1	methodological	methodological	ADJ
ecletica-1173	26	2	reductionism	reductionism	NOUN
ecletica-1173	26	3	is	be	AUX
ecletica-1173	26	4	based	base	VERB
ecletica-1173	26	5	on	on	ADP
ecletica-1173	26	6	the	the	DET
ecletica-1173	26	7	idea	idea	NOUN
ecletica-1173	26	8	that	that	SCONJ
ecletica-1173	26	9	scientific	scientific	ADJ
ecletica-1173	26	10	explanation	explanation	NOUN
ecletica-1173	26	11	must	must	AUX
ecletica-1173	26	12	be	be	AUX
ecletica-1173	26	13	reduced	reduce	VERB
ecletica-1173	26	14	to	to	ADP
ecletica-1173	26	15	the	the	DET
ecletica-1173	26	16	smallest	small	ADJ
ecletica-1173	26	17	elements	element	NOUN
ecletica-1173	26	18	.	.	PUNCT
ecletica-1173	27	1	the	the	DET
ecletica-1173	27	2	explanation	explanation	NOUN
ecletica-1173	27	3	of	of	ADP
ecletica-1173	27	4	a	a	DET
ecletica-1173	27	5	particular	particular	ADJ
ecletica-1173	27	6	phenomenon	phenomenon	NOUN
ecletica-1173	27	7	can	can	AUX
ecletica-1173	27	8	be	be	AUX
ecletica-1173	27	9	made	make	VERB
ecletica-1173	27	10	in	in	ADP
ecletica-1173	27	11	terms	term	NOUN
ecletica-1173	27	12	of	of	ADP
ecletica-1173	27	13	the	the	DET
ecletica-1173	27	14	most	most	ADV
ecletica-1173	27	15	fundamental	fundamental	ADJ
ecletica-1173	27	16	constituents	constituent	NOUN
ecletica-1173	27	17	of	of	ADP
ecletica-1173	27	18	this	this	DET
ecletica-1173	27	19	phenomenon	phenomenon	NOUN
ecletica-1173	27	20	.	.	PUNCT
ecletica-1173	28	1	the	the	DET
ecletica-1173	28	2	methodological	methodological	ADJ
ecletica-1173	28	3	reductionism	reductionism	NOUN
ecletica-1173	28	4	is	be	AUX
ecletica-1173	28	5	very	very	ADV
ecletica-1173	28	6	clear	clear	ADJ
ecletica-1173	28	7	in	in	ADP
ecletica-1173	28	8	some	some	DET
ecletica-1173	28	9	scientific	scientific	ADJ
ecletica-1173	28	10	discussion	discussion	NOUN
ecletica-1173	28	11	above	above	ADP
ecletica-1173	28	12	molecular	molecular	ADJ
ecletica-1173	28	13	drug	drug	NOUN
ecletica-1173	28	14	planning	planning	NOUN
ecletica-1173	28	15	,	,	PUNCT
ecletica-1173	28	16	because	because	SCONJ
ecletica-1173	28	17	several	several	ADJ
ecletica-1173	28	18	biochemical	biochemical	ADJ
ecletica-1173	28	19	processes	process	NOUN
ecletica-1173	28	20	are	be	AUX
ecletica-1173	28	21	described	describe	VERB
ecletica-1173	28	22	by	by	ADP
ecletica-1173	28	23	molecular	molecular	ADJ
ecletica-1173	28	24	and	and	CCONJ
ecletica-1173	28	25	atom	atom	NOUN
ecletica-1173	28	26	association	association	NOUN
ecletica-1173	28	27	.	.	PUNCT
ecletica-1173	29	1	researchers	researcher	NOUN
ecletica-1173	29	2	have	have	AUX
ecletica-1173	29	3	employed	employ	VERB
ecletica-1173	29	4	quantum	quantum	ADJ
ecletica-1173	29	5	mechanics	mechanic	NOUN
ecletica-1173	29	6	to	to	PART
ecletica-1173	29	7	describe	describe	VERB
ecletica-1173	29	8	biochemical	biochemical	ADJ
ecletica-1173	29	9	phenomena	phenomenon	NOUN
ecletica-1173	29	10	.	.	PUNCT
ecletica-1173	30	1	the	the	DET
ecletica-1173	30	2	fundamental	fundamental	ADJ
ecletica-1173	30	3	constituents	constituent	NOUN
ecletica-1173	30	4	of	of	ADP
ecletica-1173	30	5	matter	matter	NOUN
ecletica-1173	30	6	are	be	AUX
ecletica-1173	30	7	used	use	VERB
ecletica-1173	30	8	to	to	PART
ecletica-1173	30	9	develop	develop	VERB
ecletica-1173	30	10	new	new	ADJ
ecletica-1173	30	11	drugs	drug	NOUN
ecletica-1173	30	12	.	.	PUNCT
ecletica-1173	31	1	lastly	lastly	ADV
ecletica-1173	31	2	,	,	PUNCT
ecletica-1173	31	3	there	there	PRON
ecletica-1173	31	4	is	be	VERB
ecletica-1173	31	5	the	the	DET
ecletica-1173	31	6	epistemological	epistemological	ADJ
ecletica-1173	31	7	reductionism	reductionism	NOUN
ecletica-1173	31	8	,	,	PUNCT
ecletica-1173	31	9	which	which	PRON
ecletica-1173	31	10	a	a	DET
ecletica-1173	31	11	theory	theory	NOUN
ecletica-1173	31	12	takes	take	VERB
ecletica-1173	31	13	the	the	DET
ecletica-1173	31	14	form	form	NOUN
ecletica-1173	31	15	of	of	ADP
ecletica-1173	31	16	a	a	DET
ecletica-1173	31	17	deductive	deductive	ADJ
ecletica-1173	31	18	argument	argument	NOUN
ecletica-1173	31	19	where	where	SCONJ
ecletica-1173	31	20	the	the	DET
ecletica-1173	31	21	premises	premise	NOUN
ecletica-1173	31	22	are	be	AUX
ecletica-1173	31	23	the	the	DET
ecletica-1173	31	24	primary	primary	ADJ
ecletica-1173	31	25	theory	theory	NOUN
ecletica-1173	31	26	and	and	CCONJ
ecletica-1173	31	27	the	the	DET
ecletica-1173	31	28	conclusion	conclusion	NOUN
ecletica-1173	31	29	is	be	AUX
ecletica-1173	31	30	the	the	DET
ecletica-1173	31	31	secondary	secondary	ADJ
ecletica-1173	31	32	theory	theory	NOUN
ecletica-1173	31	33	.	.	PUNCT
ecletica-1173	32	1	the	the	DET
ecletica-1173	32	2	theories	theory	NOUN
ecletica-1173	32	3	of	of	ADP
ecletica-1173	32	4	biology	biology	NOUN
ecletica-1173	32	5	can	can	AUX
ecletica-1173	32	6	be	be	AUX
ecletica-1173	32	7	derived	derive	VERB
ecletica-1173	32	8	as	as	ADP
ecletica-1173	32	9	special	special	ADJ
ecletica-1173	32	10	cases	case	NOUN
ecletica-1173	32	11	of	of	ADP
ecletica-1173	32	12	the	the	DET
ecletica-1173	32	13	laws	law	NOUN
ecletica-1173	32	14	and	and	CCONJ
ecletica-1173	32	15	theories	theory	NOUN
ecletica-1173	32	16	of	of	ADP
ecletica-1173	32	17	the	the	DET
ecletica-1173	32	18	physical	physical	ADJ
ecletica-1173	32	19	sciences	science	NOUN
ecletica-1173	32	20	(	(	PUNCT
ecletica-1173	32	21	zalta	zalta	NOUN
ecletica-1173	32	22	et	et	NOUN
ecletica-1173	32	23	al	al	PROPN
ecletica-1173	32	24	.	.	PROPN
ecletica-1173	32	25	,	,	PUNCT
ecletica-1173	32	26	2017	2017	NUM
ecletica-1173	32	27	)	)	PUNCT
ecletica-1173	32	28	.	.	PUNCT
ecletica-1173	33	1	holistic	holistic	ADJ
ecletica-1173	33	2	view	view	NOUN
ecletica-1173	33	3	contrasts	contrast	VERB
ecletica-1173	33	4	with	with	ADP
ecletica-1173	33	5	the	the	DET
ecletica-1173	33	6	reductionist	reductionist	ADJ
ecletica-1173	33	7	premise	premise	NOUN
ecletica-1173	33	8	by	by	ADP
ecletica-1173	33	9	assuming	assume	VERB
ecletica-1173	33	10	that	that	SCONJ
ecletica-1173	33	11	the	the	DET
ecletica-1173	33	12	explanation	explanation	NOUN
ecletica-1173	33	13	of	of	ADP
ecletica-1173	33	14	the	the	DET
ecletica-1173	33	15	phenomenon	phenomenon	NOUN
ecletica-1173	33	16	must	must	AUX
ecletica-1173	33	17	necessarily	necessarily	ADV
ecletica-1173	33	18	describe	describe	VERB
ecletica-1173	33	19	the	the	DET
ecletica-1173	33	20	whole	whole	NOUN
ecletica-1173	33	21	.	.	PUNCT
ecletica-1173	34	1	in	in	ADP
ecletica-1173	34	2	this	this	DET
ecletica-1173	34	3	case	case	NOUN
ecletica-1173	34	4	,	,	PUNCT
ecletica-1173	34	5	the	the	DET
ecletica-1173	34	6	interactive	interactive	ADJ
ecletica-1173	34	7	aspects	aspect	NOUN
ecletica-1173	34	8	of	of	ADP
ecletica-1173	34	9	the	the	DET
ecletica-1173	34	10	individual	individual	ADJ
ecletica-1173	34	11	components	component	NOUN
ecletica-1173	34	12	are	be	AUX
ecletica-1173	34	13	considered	consider	VERB
ecletica-1173	34	14	.	.	PUNCT
ecletica-1173	35	1	in	in	ADP
ecletica-1173	35	2	this	this	DET
ecletica-1173	35	3	paper	paper	NOUN
ecletica-1173	35	4	,	,	PUNCT
ecletica-1173	35	5	the	the	DET
ecletica-1173	35	6	reductionist	reductionist	NOUN
ecletica-1173	35	7	and	and	CCONJ
ecletica-1173	35	8	holistic	holistic	ADJ
ecletica-1173	35	9	assumptions	assumption	NOUN
ecletica-1173	35	10	are	be	AUX
ecletica-1173	35	11	discussed	discuss	VERB
ecletica-1173	35	12	to	to	PART
ecletica-1173	35	13	comprehend	comprehend	VERB
ecletica-1173	35	14	diseases	disease	NOUN
ecletica-1173	35	15	and	and	CCONJ
ecletica-1173	35	16	drug	drug	NOUN
ecletica-1173	35	17	design	design	NOUN
ecletica-1173	35	18	.	.	PUNCT
ecletica-1173	36	1	this	this	DET
ecletica-1173	36	2	discussion	discussion	NOUN
ecletica-1173	36	3	is	be	AUX
ecletica-1173	36	4	interesting	interesting	ADJ
ecletica-1173	36	5	because	because	SCONJ
ecletica-1173	36	6	it	it	PRON
ecletica-1173	36	7	can	can	AUX
ecletica-1173	36	8	be	be	AUX
ecletica-1173	36	9	used	use	VERB
ecletica-1173	36	10	to	to	PART
ecletica-1173	36	11	trace	trace	VERB
ecletica-1173	36	12	the	the	DET
ecletica-1173	36	13	scientific	scientific	ADJ
ecletica-1173	36	14	pathways	pathway	NOUN
ecletica-1173	36	15	to	to	PART
ecletica-1173	36	16	be	be	AUX
ecletica-1173	36	17	used	use	VERB
ecletica-1173	36	18	in	in	ADP
ecletica-1173	36	19	the	the	DET
ecletica-1173	36	20	study	study	NOUN
ecletica-1173	36	21	of	of	ADP
ecletica-1173	36	22	a	a	DET
ecletica-1173	36	23	particular	particular	ADJ
ecletica-1173	36	24	scientific	scientific	ADJ
ecletica-1173	36	25	phenomenon	phenomenon	NOUN
ecletica-1173	36	26	.	.	PUNCT
ecletica-1173	37	1	nowadays	nowadays	ADV
ecletica-1173	37	2	,	,	PUNCT
ecletica-1173	37	3	the	the	DET
ecletica-1173	37	4	properties	property	NOUN
ecletica-1173	37	5	of	of	ADP
ecletica-1173	37	6	atoms	atom	NOUN
ecletica-1173	37	7	can	can	AUX
ecletica-1173	37	8	be	be	AUX
ecletica-1173	37	9	obtained	obtain	VERB
ecletica-1173	37	10	from	from	ADP
ecletica-1173	37	11	the	the	DET
ecletica-1173	37	12	quantum	quantum	ADJ
ecletica-1173	37	13	mechanics	mechanic	NOUN
ecletica-1173	37	14	equations	equation	NOUN
ecletica-1173	37	15	.	.	PUNCT
ecletica-1173	38	1	the	the	DET
ecletica-1173	38	2	fundamental	fundamental	ADJ
ecletica-1173	38	3	particles	particle	NOUN
ecletica-1173	38	4	,	,	PUNCT
ecletica-1173	38	5	that	that	PRON
ecletica-1173	38	6	are	be	AUX
ecletica-1173	38	7	explained	explain	VERB
ecletica-1173	38	8	by	by	ADP
ecletica-1173	38	9	quantum	quantum	ADJ
ecletica-1173	38	10	mechanics	mechanic	NOUN
ecletica-1173	38	11	,	,	PUNCT
ecletica-1173	38	12	can	can	AUX
ecletica-1173	38	13	be	be	AUX
ecletica-1173	38	14	used	use	VERB
ecletica-1173	38	15	to	to	PART
ecletica-1173	38	16	describe	describe	VERB
ecletica-1173	38	17	the	the	DET
ecletica-1173	38	18	chemical	chemical	ADJ
ecletica-1173	38	19	properties	property	NOUN
ecletica-1173	38	20	of	of	ADP
ecletica-1173	38	21	atoms	atom	NOUN
ecletica-1173	38	22	and	and	CCONJ
ecletica-1173	38	23	molecules	molecule	NOUN
ecletica-1173	38	24	.	.	PUNCT
ecletica-1173	39	1	the	the	DET
ecletica-1173	39	2	biomolecules	biomolecule	NOUN
ecletica-1173	39	3	that	that	PRON
ecletica-1173	39	4	are	be	AUX
ecletica-1173	39	5	the	the	DET
ecletica-1173	39	6	components	component	NOUN
ecletica-1173	39	7	of	of	ADP
ecletica-1173	39	8	life	life	NOUN
ecletica-1173	39	9	can	can	AUX
ecletica-1173	39	10	be	be	AUX
ecletica-1173	39	11	explained	explain	VERB
ecletica-1173	39	12	through	through	ADP
ecletica-1173	39	13	physical	physical	ADJ
ecletica-1173	39	14	and	and	CCONJ
ecletica-1173	39	15	chemical	chemical	NOUN
ecletica-1173	39	16	phenomena	phenomenon	NOUN
ecletica-1173	39	17	.	.	PUNCT
ecletica-1173	40	1	finally	finally	ADV
ecletica-1173	40	2	,	,	PUNCT
ecletica-1173	40	3	biology	biology	NOUN
ecletica-1173	40	4	becomes	become	VERB
ecletica-1173	40	5	nothing	nothing	PRON
ecletica-1173	40	6	more	more	ADJ
ecletica-1173	40	7	than	than	ADP
ecletica-1173	40	8	a	a	DET
ecletica-1173	40	9	cluster	cluster	NOUN
ecletica-1173	40	10	of	of	ADP
ecletica-1173	40	11	atoms	atom	NOUN
ecletica-1173	40	12	that	that	PRON
ecletica-1173	40	13	explain	explain	VERB
ecletica-1173	40	14	the	the	DET
ecletica-1173	40	15	phenomenon	phenomenon	NOUN
ecletica-1173	40	16	of	of	ADP
ecletica-1173	40	17	life	life	NOUN
ecletica-1173	40	18	as	as	ADP
ecletica-1173	40	19	a	a	DET
ecletica-1173	40	20	whole	whole	NOUN
ecletica-1173	40	21	.	.	PUNCT
ecletica-1173	41	1	this	this	DET
ecletica-1173	41	2	idea	idea	NOUN
ecletica-1173	41	3	was	be	AUX
ecletica-1173	41	4	advocated	advocate	VERB
ecletica-1173	41	5	by	by	ADP
ecletica-1173	41	6	schrödinger	schrödinger	ADJ
ecletica-1173	41	7	(	(	PUNCT
ecletica-1173	41	8	1946	1946	NUM
ecletica-1173	41	9	)	)	PUNCT
ecletica-1173	41	10	.	.	PUNCT
ecletica-1173	42	1	the	the	DET
ecletica-1173	42	2	reductionism	reductionism	NOUN
ecletica-1173	42	3	gains	gain	VERB
ecletica-1173	42	4	a	a	DET
ecletica-1173	42	5	new	new	ADJ
ecletica-1173	42	6	perspective	perspective	NOUN
ecletica-1173	42	7	by	by	ADP
ecletica-1173	42	8	quantum	quantum	ADJ
ecletica-1173	42	9	theory	theory	NOUN
ecletica-1173	42	10	.	.	PUNCT
ecletica-1173	43	1	individual	individual	ADJ
ecletica-1173	43	2	molecules	molecule	NOUN
ecletica-1173	43	3	can	can	AUX
ecletica-1173	43	4	be	be	AUX
ecletica-1173	43	5	used	use	VERB
ecletica-1173	43	6	to	to	PART
ecletica-1173	43	7	explain	explain	VERB
ecletica-1173	43	8	diseases	disease	NOUN
ecletica-1173	43	9	as	as	ADP
ecletica-1173	43	10	a	a	DET
ecletica-1173	43	11	whole	whole	NOUN
ecletica-1173	43	12	.	.	PUNCT
ecletica-1173	44	1	defective	defective	ADJ
ecletica-1173	44	2	genes	gene	NOUN
ecletica-1173	44	3	may	may	AUX
ecletica-1173	44	4	be	be	AUX
ecletica-1173	44	5	the	the	DET
ecletica-1173	44	6	cause	cause	NOUN
ecletica-1173	44	7	of	of	ADP
ecletica-1173	44	8	cancer	cancer	NOUN
ecletica-1173	44	9	.	.	PUNCT
ecletica-1173	45	1	a	a	DET
ecletica-1173	45	2	drug	drug	NOUN
ecletica-1173	45	3	can	can	AUX
ecletica-1173	45	4	be	be	AUX
ecletica-1173	45	5	designed	design	VERB
ecletica-1173	45	6	due	due	ADP
ecletica-1173	45	7	to	to	ADP
ecletica-1173	45	8	the	the	DET
ecletica-1173	45	9	idea	idea	NOUN
ecletica-1173	45	10	that	that	SCONJ
ecletica-1173	45	11	a	a	DET
ecletica-1173	45	12	specific	specific	ADJ
ecletica-1173	45	13	enzyme	enzyme	NOUN
ecletica-1173	45	14	interacts	interact	VERB
ecletica-1173	45	15	with	with	ADP
ecletica-1173	45	16	a	a	DET
ecletica-1173	45	17	biological	biological	ADJ
ecletica-1173	45	18	receptor	receptor	NOUN
ecletica-1173	45	19	.	.	PUNCT
ecletica-1173	46	1	this	this	DET
ecletica-1173	46	2	molecular	molecular	ADJ
ecletica-1173	46	3	interaction	interaction	NOUN
ecletica-1173	46	4	controls	control	VERB
ecletica-1173	46	5	a	a	DET
ecletica-1173	46	6	complex	complex	ADJ
ecletica-1173	46	7	biological	biological	ADJ
ecletica-1173	46	8	response	response	NOUN
ecletica-1173	46	9	.	.	PUNCT
ecletica-1173	47	1	currently	currently	ADV
ecletica-1173	47	2	,	,	PUNCT
ecletica-1173	47	3	reductionism	reductionism	NOUN
ecletica-1173	47	4	is	be	AUX
ecletica-1173	47	5	the	the	DET
ecletica-1173	47	6	theory	theory	NOUN
ecletica-1173	47	7	most	most	ADV
ecletica-1173	47	8	employed	employ	VERB
ecletica-1173	47	9	to	to	PART
ecletica-1173	47	10	understand	understand	VERB
ecletica-1173	47	11	the	the	DET
ecletica-1173	47	12	existence	existence	NOUN
ecletica-1173	47	13	of	of	ADP
ecletica-1173	47	14	diseases	disease	NOUN
ecletica-1173	47	15	and	and	CCONJ
ecletica-1173	47	16	design	design	VERB
ecletica-1173	47	17	new	new	ADJ
ecletica-1173	47	18	drugs	drug	NOUN
ecletica-1173	47	19	for	for	ADP
ecletica-1173	47	20	treating	treat	VERB
ecletica-1173	47	21	illness	illness	NOUN
ecletica-1173	47	22	.	.	PUNCT
ecletica-1173	48	1	in	in	ADP
ecletica-1173	48	2	opposition	opposition	NOUN
ecletica-1173	48	3	to	to	ADP
ecletica-1173	48	4	reductionism	reductionism	NOUN
ecletica-1173	48	5	,	,	PUNCT
ecletica-1173	48	6	the	the	DET
ecletica-1173	48	7	holistic	holistic	ADJ
ecletica-1173	48	8	vision	vision	NOUN
ecletica-1173	48	9	assumes	assume	VERB
ecletica-1173	48	10	that	that	SCONJ
ecletica-1173	48	11	diseases	disease	NOUN
ecletica-1173	48	12	must	must	AUX
ecletica-1173	48	13	be	be	AUX
ecletica-1173	48	14	comprehended	comprehend	VERB
ecletica-1173	48	15	by	by	ADP
ecletica-1173	48	16	individual	individual	ADJ
ecletica-1173	48	17	components	component	NOUN
ecletica-1173	48	18	interactions	interaction	NOUN
ecletica-1173	48	19	.	.	PUNCT
ecletica-1173	49	1	in	in	ADP
ecletica-1173	49	2	order	order	NOUN
ecletica-1173	49	3	to	to	PART
ecletica-1173	49	4	develop	develop	VERB
ecletica-1173	49	5	new	new	ADJ
ecletica-1173	49	6	drugs	drug	NOUN
ecletica-1173	49	7	,	,	PUNCT
ecletica-1173	49	8	the	the	DET
ecletica-1173	49	9	researcher	researcher	NOUN
ecletica-1173	49	10	must	must	AUX
ecletica-1173	49	11	study	study	VERB
ecletica-1173	49	12	the	the	DET
ecletica-1173	49	13	biological	biological	ADJ
ecletica-1173	49	14	system	system	NOUN
ecletica-1173	49	15	as	as	ADP
ecletica-1173	49	16	a	a	DET
ecletica-1173	49	17	whole	whole	NOUN
ecletica-1173	49	18	.	.	PUNCT
ecletica-1173	50	1	a	a	DET
ecletica-1173	50	2	molecule	molecule	NOUN
ecletica-1173	50	3	does	do	AUX
ecletica-1173	50	4	not	not	PART
ecletica-1173	50	5	interact	interact	VERB
ecletica-1173	50	6	with	with	ADP
ecletica-1173	50	7	a	a	DET
ecletica-1173	50	8	single	single	ADJ
ecletica-1173	50	9	enzyme	enzyme	NOUN
ecletica-1173	50	10	because	because	SCONJ
ecletica-1173	50	11	it	it	PRON
ecletica-1173	50	12	can	can	AUX
ecletica-1173	50	13	have	have	VERB
ecletica-1173	50	14	a	a	DET
ecletica-1173	50	15	different	different	ADJ
ecletica-1173	50	16	effect	effect	NOUN
ecletica-1173	50	17	from	from	ADP
ecletica-1173	50	18	what	what	PRON
ecletica-1173	50	19	was	be	AUX
ecletica-1173	50	20	planned	plan	VERB
ecletica-1173	50	21	.	.	PUNCT
ecletica-1173	51	1	biochemical	biochemical	ADJ
ecletica-1173	51	2	mechanisms	mechanism	NOUN
ecletica-1173	51	3	should	should	AUX
ecletica-1173	51	4	be	be	AUX
ecletica-1173	51	5	understood	understand	VERB
ecletica-1173	51	6	based	base	VERB
ecletica-1173	51	7	on	on	ADP
ecletica-1173	51	8	the	the	DET
ecletica-1173	51	9	interactions	interaction	NOUN
ecletica-1173	51	10	between	between	ADP
ecletica-1173	51	11	the	the	DET
ecletica-1173	51	12	biomolecules	biomolecule	NOUN
ecletica-1173	51	13	as	as	ADP
ecletica-1173	51	14	a	a	DET
ecletica-1173	51	15	whole	whole	NOUN
ecletica-1173	51	16	and	and	CCONJ
ecletica-1173	51	17	not	not	PART
ecletica-1173	51	18	as	as	ADP
ecletica-1173	51	19	a	a	DET
ecletica-1173	51	20	summation	summation	NOUN
ecletica-1173	51	21	of	of	ADP
ecletica-1173	51	22	individual	individual	ADJ
ecletica-1173	51	23	properties	property	NOUN
ecletica-1173	51	24	.	.	PUNCT
ecletica-1173	52	1	thus	thus	ADV
ecletica-1173	52	2	,	,	PUNCT
ecletica-1173	52	3	it	it	PRON
ecletica-1173	52	4	is	be	AUX
ecletica-1173	52	5	important	important	ADJ
ecletica-1173	52	6	that	that	SCONJ
ecletica-1173	52	7	the	the	DET
ecletica-1173	52	8	researcher	researcher	NOUN
ecletica-1173	52	9	gives	give	VERB
ecletica-1173	52	10	special	special	ADJ
ecletica-1173	52	11	attention	attention	NOUN
ecletica-1173	52	12	to	to	ADP
ecletica-1173	52	13	these	these	DET
ecletica-1173	52	14	visions	vision	NOUN
ecletica-1173	52	15	in	in	ADP
ecletica-1173	52	16	order	order	NOUN
ecletica-1173	52	17	to	to	PART
ecletica-1173	52	18	find	find	VERB
ecletica-1173	52	19	a	a	DET
ecletica-1173	52	20	way	way	NOUN
ecletica-1173	52	21	to	to	PART
ecletica-1173	52	22	understand	understand	VERB
ecletica-1173	52	23	the	the	DET
ecletica-1173	52	24	biological	biological	ADJ
ecletica-1173	52	25	mechanisms	mechanism	NOUN
ecletica-1173	52	26	and	and	CCONJ
ecletica-1173	52	27	rules	rule	NOUN
ecletica-1173	52	28	that	that	PRON
ecletica-1173	52	29	govern	govern	VERB
ecletica-1173	52	30	life	life	NOUN
ecletica-1173	52	31	.	.	PUNCT
ecletica-1173	53	1	in	in	ADP
ecletica-1173	53	2	this	this	DET
ecletica-1173	53	3	manuscript	manuscript	NOUN
ecletica-1173	53	4	,	,	PUNCT
ecletica-1173	53	5	the	the	DET
ecletica-1173	53	6	discussion	discussion	NOUN
ecletica-1173	53	7	of	of	ADP
ecletica-1173	53	8	reductionism	reductionism	NOUN
ecletica-1173	53	9	is	be	AUX
ecletica-1173	53	10	performed	perform	VERB
ecletica-1173	53	11	at	at	ADP
ecletica-1173	53	12	the	the	DET
ecletica-1173	53	13	biological	biological	ADJ
ecletica-1173	53	14	,	,	PUNCT
ecletica-1173	53	15	chemical	chemical	NOUN
ecletica-1173	53	16	,	,	PUNCT
ecletica-1173	53	17	and	and	CCONJ
ecletica-1173	53	18	physical	physical	ADJ
ecletica-1173	53	19	levels	level	NOUN
ecletica-1173	53	20	to	to	PART
ecletica-1173	53	21	understand	understand	VERB
ecletica-1173	53	22	the	the	DET
ecletica-1173	53	23	development	development	NOUN
ecletica-1173	53	24	of	of	ADP
ecletica-1173	53	25	drugs	drug	NOUN
ecletica-1173	53	26	and	and	CCONJ
ecletica-1173	53	27	diseases	disease	NOUN
ecletica-1173	53	28	.	.	PUNCT
ecletica-1173	54	1	after	after	ADP
ecletica-1173	54	2	the	the	DET
ecletica-1173	54	3	previous	previous	ADJ
ecletica-1173	54	4	discussion	discussion	NOUN
ecletica-1173	54	5	about	about	ADP
ecletica-1173	54	6	reductionism	reductionism	NOUN
ecletica-1173	54	7	paradigms	paradigm	NOUN
ecletica-1173	54	8	applied	apply	VERB
ecletica-1173	54	9	to	to	ADP
ecletica-1173	54	10	drug	drug	NOUN
ecletica-1173	54	11	discovery	discovery	NOUN
ecletica-1173	54	12	,	,	PUNCT
ecletica-1173	54	13	the	the	DET
ecletica-1173	54	14	holistic	holistic	ADJ
ecletica-1173	54	15	idea	idea	NOUN
ecletica-1173	54	16	is	be	AUX
ecletica-1173	54	17	discussed	discuss	VERB
ecletica-1173	54	18	in	in	ADP
ecletica-1173	54	19	order	order	NOUN
ecletica-1173	54	20	to	to	PART
ecletica-1173	54	21	understand	understand	VERB
ecletica-1173	54	22	the	the	DET
ecletica-1173	54	23	same	same	ADJ
ecletica-1173	54	24	problems	problem	NOUN
ecletica-1173	54	25	using	use	VERB
ecletica-1173	54	26	the	the	DET
ecletica-1173	54	27	biology	biology	NOUN
ecletica-1173	54	28	of	of	ADP
ecletica-1173	54	29	systems	system	NOUN
ecletica-1173	54	30	.	.	PUNCT
ecletica-1173	55	1	methodological	methodological	ADJ
ecletica-1173	55	2	reductionism	reductionism	NOUN
ecletica-1173	55	3	and	and	CCONJ
ecletica-1173	55	4	holism	holism	NOUN
ecletica-1173	55	5	are	be	AUX
ecletica-1173	55	6	not	not	PART
ecletica-1173	55	7	entirely	entirely	ADV
ecletica-1173	55	8	opposite	opposite	ADJ
ecletica-1173	55	9	to	to	ADP
ecletica-1173	55	10	each	each	DET
ecletica-1173	55	11	other	other	ADJ
ecletica-1173	55	12	.	.	PUNCT
ecletica-1173	56	1	each	each	DET
ecletica-1173	56	2	approach	approach	NOUN
ecletica-1173	56	3	has	have	VERB
ecletica-1173	56	4	limitations	limitation	NOUN
ecletica-1173	56	5	.	.	PUNCT
ecletica-1173	57	1	2	2	X
ecletica-1173	57	2	.	.	X
ecletica-1173	57	3	methodology	methodology	NOUN
ecletica-1173	57	4	the	the	DET
ecletica-1173	57	5	purpose	purpose	NOUN
ecletica-1173	57	6	of	of	ADP
ecletica-1173	57	7	this	this	DET
ecletica-1173	57	8	manuscript	manuscript	NOUN
ecletica-1173	57	9	is	be	AUX
ecletica-1173	57	10	to	to	PART
ecletica-1173	57	11	show	show	VERB
ecletica-1173	57	12	how	how	SCONJ
ecletica-1173	57	13	ontological	ontological	ADJ
ecletica-1173	57	14	reductionism	reductionism	NOUN
ecletica-1173	57	15	brings	bring	VERB
ecletica-1173	57	16	difficulties	difficulty	NOUN
ecletica-1173	57	17	to	to	PART
ecletica-1173	57	18	understand	understand	VERB
ecletica-1173	57	19	diseases	disease	NOUN
ecletica-1173	57	20	and	and	CCONJ
ecletica-1173	57	21	design	design	VERB
ecletica-1173	57	22	new	new	ADJ
ecletica-1173	57	23	drugs	drug	NOUN
ecletica-1173	57	24	.	.	PUNCT
ecletica-1173	58	1	holistic	holistic	ADJ
ecletica-1173	58	2	approach	approach	NOUN
ecletica-1173	58	3	derived	derive	VERB
ecletica-1173	58	4	from	from	ADP
ecletica-1173	58	5	the	the	DET
ecletica-1173	58	6	biology	biology	NOUN
ecletica-1173	58	7	of	of	ADP
ecletica-1173	58	8	the	the	DET
ecletica-1173	58	9	system	system	NOUN
ecletica-1173	58	10	is	be	AUX
ecletica-1173	58	11	presented	present	VERB
ecletica-1173	58	12	in	in	ADP
ecletica-1173	58	13	the	the	DET
ecletica-1173	58	14	manuscript	manuscript	NOUN
ecletica-1173	58	15	.	.	PUNCT
ecletica-1173	59	1	this	this	DET
ecletica-1173	59	2	discussion	discussion	NOUN
ecletica-1173	59	3	extends	extend	VERB
ecletica-1173	59	4	at	at	ADP
ecletica-1173	59	5	a	a	DET
ecletica-1173	59	6	biological	biological	ADJ
ecletica-1173	59	7	,	,	PUNCT
ecletica-1173	59	8	chemical	chemical	NOUN
ecletica-1173	59	9	,	,	PUNCT
ecletica-1173	59	10	and	and	CCONJ
ecletica-1173	59	11	physical	physical	ADJ
ecletica-1173	59	12	level	level	NOUN
ecletica-1173	59	13	.	.	PUNCT
ecletica-1173	60	1	the	the	DET
ecletica-1173	60	2	old	old	ADJ
ecletica-1173	60	3	and	and	CCONJ
ecletica-1173	60	4	current	current	ADJ
ecletica-1173	60	5	literature	literature	NOUN
ecletica-1173	60	6	were	be	AUX
ecletica-1173	60	7	also	also	ADV
ecletica-1173	60	8	evaluated	evaluate	VERB
ecletica-1173	60	9	to	to	PART
ecletica-1173	60	10	show	show	VERB
ecletica-1173	60	11	the	the	DET
ecletica-1173	60	12	two	two	NUM
ecletica-1173	60	13	premises	premise	NOUN
ecletica-1173	60	14	adopted	adopt	VERB
ecletica-1173	60	15	in	in	ADP
ecletica-1173	60	16	the	the	DET
ecletica-1173	60	17	study	study	NOUN
ecletica-1173	60	18	and	and	CCONJ
ecletica-1173	60	19	development	development	NOUN
ecletica-1173	60	20	of	of	ADP
ecletica-1173	60	21	drugs	drug	NOUN
ecletica-1173	60	22	.	.	PUNCT
ecletica-1173	61	1	finally	finally	ADV
ecletica-1173	61	2	,	,	PUNCT
ecletica-1173	61	3	methodological	methodological	ADJ
ecletica-1173	61	4	reductionism	reductionism	NOUN
ecletica-1173	61	5	is	be	AUX
ecletica-1173	61	6	used	use	VERB
ecletica-1173	61	7	to	to	PART
ecletica-1173	61	8	build	build	VERB
ecletica-1173	61	9	holistic	holistic	ADJ
ecletica-1173	61	10	approaches	approach	NOUN
ecletica-1173	61	11	,	,	PUNCT
ecletica-1173	61	12	showing	show	VERB
ecletica-1173	61	13	the	the	DET
ecletica-1173	61	14	complementarity	complementarity	NOUN
ecletica-1173	61	15	of	of	ADP
ecletica-1173	61	16	both	both	DET
ecletica-1173	61	17	approaches	approach	NOUN
ecletica-1173	61	18	.	.	PUNCT
ecletica-1173	62	1	3	3	X
ecletica-1173	62	2	.	.	X
ecletica-1173	62	3	drug	drug	NOUN
ecletica-1173	62	4	design	design	VERB
ecletica-1173	62	5	the	the	DET
ecletica-1173	62	6	discussion	discussion	NOUN
ecletica-1173	62	7	on	on	ADP
ecletica-1173	62	8	the	the	DET
ecletica-1173	62	9	use	use	NOUN
ecletica-1173	62	10	of	of	ADP
ecletica-1173	62	11	proteins	protein	NOUN
ecletica-1173	62	12	in	in	ADP
ecletica-1173	62	13	drug	drug	NOUN
ecletica-1173	62	14	design	design	NOUN
ecletica-1173	62	15	began	begin	VERB
ecletica-1173	62	16	more	more	ADJ
ecletica-1173	62	17	than	than	ADP
ecletica-1173	62	18	35	35	NUM
ecletica-1173	62	19	years	year	NOUN
ecletica-1173	62	20	ago	ago	ADV
ecletica-1173	62	21	with	with	ADP
ecletica-1173	62	22	the	the	DET
ecletica-1173	62	23	emergence	emergence	NOUN
ecletica-1173	62	24	of	of	ADP
ecletica-1173	62	25	information	information	NOUN
ecletica-1173	62	26	on	on	ADP
ecletica-1173	62	27	the	the	DET
ecletica-1173	62	28	three	three	NUM
ecletica-1173	62	29	-	-	PUNCT
ecletica-1173	62	30	dimensional	dimensional	ADJ
ecletica-1173	62	31	(	(	PUNCT
ecletica-1173	62	32	3d	3d	NOUN
ecletica-1173	62	33	)	)	PUNCT
ecletica-1173	62	34	structure	structure	NOUN
ecletica-1173	62	35	of	of	ADP
ecletica-1173	62	36	globin	globin	NOUN
ecletica-1173	62	37	and	and	CCONJ
ecletica-1173	62	38	polypeptide	polypeptide	ADJ
ecletica-1173	62	39	hormones	hormone	NOUN
ecletica-1173	62	40	(	(	PUNCT
ecletica-1173	62	41	schechter	schechter	NOUN
ecletica-1173	62	42	,	,	PUNCT
ecletica-1173	62	43	2008	2008	NUM
ecletica-1173	62	44	)	)	PUNCT
ecletica-1173	62	45	.	.	PUNCT
ecletica-1173	63	1	the	the	DET
ecletica-1173	63	2	protein	protein	NOUN
ecletica-1173	63	3	structures	structure	NOUN
ecletica-1173	63	4	are	be	AUX
ecletica-1173	63	5	used	use	VERB
ecletica-1173	63	6	as	as	ADP
ecletica-1173	63	7	biological	biological	ADJ
ecletica-1173	63	8	targets	target	NOUN
ecletica-1173	63	9	,	,	PUNCT
ecletica-1173	63	10	virtual	virtual	ADJ
ecletica-1173	63	11	screening	screening	NOUN
ecletica-1173	63	12	and	and	CCONJ
ecletica-1173	63	13	fragment	fragment	NOUN
ecletica-1173	63	14	screening	screening	NOUN
ecletica-1173	63	15	.	.	PUNCT
ecletica-1173	64	1	http://revista.iq.unesp.br/ojs/index.php/ecletica/index	http://revista.iq.unesp.br/ojs/index.php/ecletica/index	NOUN
ecletica-1173	64	2	https://doi.org/10.26850/1678-4618eqj.v46.3.2021.p17-32	https://doi.org/10.26850/1678-4618eqj.v46.3.2021.p17-32	PROPN
ecletica-1173	64	3	review	review	NOUN
ecletica-1173	64	4	article	article	NOUN
ecletica-1173	64	5	iq.unesp.br/ecletica	iq.unesp.br/ecletica	PROPN
ecletica-1173	64	6	19	19	NUM
ecletica-1173	64	7	eclética	eclética	PROPN
ecletica-1173	64	8	química	química	PROPN
ecletica-1173	64	9	journal	journal	PROPN
ecletica-1173	64	10	,	,	PUNCT
ecletica-1173	64	11	vol	vol	NOUN
ecletica-1173	64	12	.	.	PROPN
ecletica-1173	64	13	46	46	NUM
ecletica-1173	64	14	,	,	PUNCT
ecletica-1173	64	15	n.	n.	NOUN
ecletica-1173	64	16	3	3	NUM
ecletica-1173	64	17	,	,	PUNCT
ecletica-1173	64	18	2021	2021	NUM
ecletica-1173	64	19	,	,	PUNCT
ecletica-1173	64	20	17	17	NUM
ecletica-1173	64	21	-	-	SYM
ecletica-1173	64	22	32	32	NUM
ecletica-1173	64	23	issn	issn	NOUN
ecletica-1173	64	24	:	:	PUNCT
ecletica-1173	64	25	1678	1678	NUM
ecletica-1173	64	26	-	-	SYM
ecletica-1173	64	27	4618	4618	NUM
ecletica-1173	64	28	doi	doi	NOUN
ecletica-1173	64	29	:	:	PUNCT
ecletica-1173	64	30	10.26850/1678	10.26850/1678	NUM
ecletica-1173	64	31	-	-	SYM
ecletica-1173	64	32	4618eqj.v46.3.2021.p17	4618eqj.v46.3.2021.p17	NOUN
ecletica-1173	64	33	-	-	PUNCT
ecletica-1173	64	34	32	32	NUM
ecletica-1173	64	35	the	the	DET
ecletica-1173	64	36	development	development	NOUN
ecletica-1173	64	37	of	of	ADP
ecletica-1173	64	38	structural	structural	ADJ
ecletica-1173	64	39	genomics	genomic	NOUN
ecletica-1173	64	40	provided	provide	VERB
ecletica-1173	64	41	more	more	ADJ
ecletica-1173	64	42	3d	3d	NUM
ecletica-1173	64	43	structures	structure	NOUN
ecletica-1173	64	44	that	that	PRON
ecletica-1173	64	45	can	can	AUX
ecletica-1173	64	46	be	be	AUX
ecletica-1173	64	47	determined	determine	VERB
ecletica-1173	64	48	by	by	ADP
ecletica-1173	64	49	gene	gene	NOUN
ecletica-1173	64	50	sequences	sequence	NOUN
ecletica-1173	64	51	.	.	PUNCT
ecletica-1173	65	1	these	these	DET
ecletica-1173	65	2	methodologies	methodology	NOUN
ecletica-1173	65	3	were	be	AUX
ecletica-1173	65	4	particularly	particularly	ADV
ecletica-1173	65	5	important	important	ADJ
ecletica-1173	65	6	for	for	ADP
ecletica-1173	65	7	the	the	DET
ecletica-1173	65	8	development	development	NOUN
ecletica-1173	65	9	of	of	ADP
ecletica-1173	65	10	computational	computational	ADJ
ecletica-1173	65	11	methods	method	NOUN
ecletica-1173	65	12	,	,	PUNCT
ecletica-1173	65	13	which	which	PRON
ecletica-1173	65	14	can	can	AUX
ecletica-1173	65	15	help	help	VERB
ecletica-1173	65	16	to	to	PART
ecletica-1173	65	17	identify	identify	VERB
ecletica-1173	65	18	the	the	DET
ecletica-1173	65	19	sites	site	NOUN
ecletica-1173	65	20	involved	involve	VERB
ecletica-1173	65	21	in	in	ADP
ecletica-1173	65	22	the	the	DET
ecletica-1173	65	23	intermolecular	intermolecular	ADJ
ecletica-1173	65	24	interaction	interaction	NOUN
ecletica-1173	65	25	with	with	ADP
ecletica-1173	65	26	the	the	DET
ecletica-1173	65	27	inhibitors	inhibitor	NOUN
ecletica-1173	65	28	.	.	PUNCT
ecletica-1173	66	1	first	first	ADV
ecletica-1173	66	2	,	,	PUNCT
ecletica-1173	66	3	it	it	PRON
ecletica-1173	66	4	is	be	AUX
ecletica-1173	66	5	possible	possible	ADJ
ecletica-1173	66	6	to	to	PART
ecletica-1173	66	7	use	use	VERB
ecletica-1173	66	8	silicon	silicon	NOUN
ecletica-1173	66	9	approaches	approach	NOUN
ecletica-1173	66	10	(	(	PUNCT
ecletica-1173	66	11	virtual	virtual	ADJ
ecletica-1173	66	12	screening	screening	NOUN
ecletica-1173	66	13	and	and	CCONJ
ecletica-1173	66	14	redesign	redesign	NOUN
ecletica-1173	66	15	)	)	PUNCT
ecletica-1173	66	16	to	to	PART
ecletica-1173	66	17	select	select	VERB
ecletica-1173	66	18	a	a	DET
ecletica-1173	66	19	subset	subset	NOUN
ecletica-1173	66	20	of	of	ADP
ecletica-1173	66	21	samples	sample	NOUN
ecletica-1173	66	22	from	from	ADP
ecletica-1173	66	23	a	a	DET
ecletica-1173	66	24	large	large	ADJ
ecletica-1173	66	25	compound	compound	NOUN
ecletica-1173	66	26	file	file	NOUN
ecletica-1173	66	27	.	.	PUNCT
ecletica-1173	67	1	a	a	DET
ecletica-1173	67	2	new	new	ADJ
ecletica-1173	67	3	drug	drug	NOUN
ecletica-1173	67	4	can	can	AUX
ecletica-1173	67	5	also	also	ADV
ecletica-1173	67	6	be	be	AUX
ecletica-1173	67	7	designed	design	VERB
ecletica-1173	67	8	from	from	ADP
ecletica-1173	67	9	previously	previously	ADV
ecletica-1173	67	10	identified	identify	VERB
ecletica-1173	67	11	ligands	ligand	NOUN
ecletica-1173	67	12	.	.	PUNCT
ecletica-1173	68	1	secondly	secondly	ADV
ecletica-1173	68	2	,	,	PUNCT
ecletica-1173	68	3	molecular	molecular	ADJ
ecletica-1173	68	4	modeling	modeling	NOUN
ecletica-1173	68	5	can	can	AUX
ecletica-1173	68	6	be	be	AUX
ecletica-1173	68	7	used	use	VERB
ecletica-1173	68	8	to	to	PART
ecletica-1173	68	9	study	study	VERB
ecletica-1173	68	10	the	the	DET
ecletica-1173	68	11	interaction	interaction	NOUN
ecletica-1173	68	12	between	between	ADP
ecletica-1173	68	13	a	a	DET
ecletica-1173	68	14	possible	possible	ADJ
ecletica-1173	68	15	biological	biological	ADJ
ecletica-1173	68	16	target	target	NOUN
ecletica-1173	68	17	and	and	CCONJ
ecletica-1173	68	18	the	the	DET
ecletica-1173	68	19	protein	protein	NOUN
ecletica-1173	68	20	receptor	receptor	NOUN
ecletica-1173	68	21	.	.	PUNCT
ecletica-1173	69	1	the	the	DET
ecletica-1173	69	2	evaluation	evaluation	NOUN
ecletica-1173	69	3	of	of	ADP
ecletica-1173	69	4	the	the	DET
ecletica-1173	69	5	activity	activity	NOUN
ecletica-1173	69	6	of	of	ADP
ecletica-1173	69	7	a	a	DET
ecletica-1173	69	8	possible	possible	ADJ
ecletica-1173	69	9	drug	drug	NOUN
ecletica-1173	69	10	can	can	AUX
ecletica-1173	69	11	be	be	AUX
ecletica-1173	69	12	made	make	VERB
ecletica-1173	69	13	by	by	ADP
ecletica-1173	69	14	the	the	DET
ecletica-1173	69	15	similarity	similarity	NOUN
ecletica-1173	69	16	to	to	ADP
ecletica-1173	69	17	the	the	DET
ecletica-1173	69	18	original	original	ADJ
ecletica-1173	69	19	substrate	substrate	NOUN
ecletica-1173	69	20	,	,	PUNCT
ecletica-1173	69	21	through	through	ADP
ecletica-1173	69	22	the	the	DET
ecletica-1173	69	23	interactions	interaction	NOUN
ecletica-1173	69	24	performed	perform	VERB
ecletica-1173	69	25	by	by	ADP
ecletica-1173	69	26	the	the	DET
ecletica-1173	69	27	possible	possible	ADJ
ecletica-1173	69	28	drug	drug	NOUN
ecletica-1173	69	29	,	,	PUNCT
ecletica-1173	69	30	or	or	CCONJ
ecletica-1173	69	31	using	use	VERB
ecletica-1173	69	32	a	a	DET
ecletica-1173	69	33	multilinear	multilinear	ADJ
ecletica-1173	69	34	regression	regression	NOUN
ecletica-1173	69	35	to	to	PART
ecletica-1173	69	36	perform	perform	VERB
ecletica-1173	69	37	a	a	DET
ecletica-1173	69	38	study	study	NOUN
ecletica-1173	69	39	of	of	ADP
ecletica-1173	69	40	structure	structure	NOUN
ecletica-1173	69	41	and	and	CCONJ
ecletica-1173	69	42	activity	activity	NOUN
ecletica-1173	69	43	relationship	relationship	NOUN
ecletica-1173	69	44	.	.	PUNCT
ecletica-1173	70	1	molecular	molecular	ADJ
ecletica-1173	70	2	modeling	modeling	NOUN
ecletica-1173	70	3	uses	use	VERB
ecletica-1173	70	4	molecular	molecular	ADJ
ecletica-1173	70	5	structure	structure	NOUN
ecletica-1173	70	6	and	and	CCONJ
ecletica-1173	70	7	electronic	electronic	ADJ
ecletica-1173	70	8	calculations	calculation	NOUN
ecletica-1173	70	9	to	to	PART
ecletica-1173	70	10	study	study	VERB
ecletica-1173	70	11	conformational	conformational	ADJ
ecletica-1173	70	12	changes	change	NOUN
ecletica-1173	70	13	and	and	CCONJ
ecletica-1173	70	14	molecular	molecular	ADJ
ecletica-1173	70	15	interactions	interaction	NOUN
ecletica-1173	70	16	between	between	ADP
ecletica-1173	70	17	an	an	DET
ecletica-1173	70	18	enzyme	enzyme	NOUN
ecletica-1173	70	19	and	and	CCONJ
ecletica-1173	70	20	a	a	DET
ecletica-1173	70	21	potential	potential	ADJ
ecletica-1173	70	22	drug	drug	NOUN
ecletica-1173	70	23	candidate	candidate	NOUN
ecletica-1173	70	24	.	.	PUNCT
ecletica-1173	71	1	the	the	DET
ecletica-1173	71	2	electronic	electronic	ADJ
ecletica-1173	71	3	structure	structure	NOUN
ecletica-1173	71	4	calculations	calculation	NOUN
ecletica-1173	71	5	are	be	AUX
ecletica-1173	71	6	based	base	VERB
ecletica-1173	71	7	on	on	ADP
ecletica-1173	71	8	methodologies	methodology	NOUN
ecletica-1173	71	9	derivative	derivative	ADJ
ecletica-1173	71	10	from	from	ADP
ecletica-1173	71	11	quantum	quantum	ADJ
ecletica-1173	71	12	mechanics	mechanic	NOUN
ecletica-1173	71	13	approximations	approximation	NOUN
ecletica-1173	71	14	.	.	PUNCT
ecletica-1173	72	1	now	now	ADV
ecletica-1173	72	2	,	,	PUNCT
ecletica-1173	72	3	there	there	PRON
ecletica-1173	72	4	is	be	VERB
ecletica-1173	72	5	prior	prior	ADJ
ecletica-1173	72	6	information	information	NOUN
ecletica-1173	72	7	(	(	PUNCT
ecletica-1173	72	8	docking	docking	NOUN
ecletica-1173	72	9	,	,	PUNCT
ecletica-1173	72	10	quantum	quantum	ADJ
ecletica-1173	72	11	chemistry	chemistry	NOUN
ecletica-1173	72	12	simulations	simulation	NOUN
ecletica-1173	72	13	,	,	PUNCT
ecletica-1173	72	14	quantitative	quantitative	ADJ
ecletica-1173	72	15	structure	structure	NOUN
ecletica-1173	72	16	–	–	PUNCT
ecletica-1173	72	17	activity	activity	NOUN
ecletica-1173	72	18	relationship	relationship	NOUN
ecletica-1173	73	1	[	[	X
ecletica-1173	73	2	qsar	qsar	NOUN
ecletica-1173	73	3	]	]	PUNCT
ecletica-1173	73	4	)	)	PUNCT
ecletica-1173	73	5	for	for	ADP
ecletica-1173	73	6	a	a	DET
ecletica-1173	73	7	rational	rational	ADJ
ecletica-1173	73	8	organic	organic	ADJ
ecletica-1173	73	9	synthesis	synthesis	NOUN
ecletica-1173	73	10	of	of	ADP
ecletica-1173	73	11	the	the	DET
ecletica-1173	73	12	new	new	ADJ
ecletica-1173	73	13	drug	drug	NOUN
ecletica-1173	73	14	.	.	PUNCT
ecletica-1173	74	1	the	the	DET
ecletica-1173	74	2	synthesized	synthesize	VERB
ecletica-1173	74	3	drug	drug	NOUN
ecletica-1173	74	4	will	will	AUX
ecletica-1173	74	5	be	be	AUX
ecletica-1173	74	6	tested	test	VERB
ecletica-1173	74	7	in	in	ADP
ecletica-1173	74	8	vitro	vitro	X
ecletica-1173	74	9	and	and	CCONJ
ecletica-1173	74	10	in	in	ADP
ecletica-1173	74	11	vivo	vivo	NOUN
ecletica-1173	74	12	.	.	PUNCT
ecletica-1173	75	1	the	the	DET
ecletica-1173	75	2	success	success	NOUN
ecletica-1173	75	3	of	of	ADP
ecletica-1173	75	4	these	these	DET
ecletica-1173	75	5	tests	test	NOUN
ecletica-1173	75	6	may	may	AUX
ecletica-1173	75	7	or	or	CCONJ
ecletica-1173	75	8	may	may	AUX
ecletica-1173	75	9	not	not	PART
ecletica-1173	75	10	lead	lead	VERB
ecletica-1173	75	11	to	to	ADP
ecletica-1173	75	12	a	a	DET
ecletica-1173	75	13	new	new	ADJ
ecletica-1173	75	14	drug	drug	NOUN
ecletica-1173	75	15	.	.	PUNCT
ecletica-1173	76	1	briefly	briefly	NOUN
ecletica-1173	76	2	,	,	PUNCT
ecletica-1173	76	3	rational	rational	ADJ
ecletica-1173	76	4	drug	drug	NOUN
ecletica-1173	76	5	design	design	NOUN
ecletica-1173	76	6	is	be	AUX
ecletica-1173	76	7	preceded	precede	VERB
ecletica-1173	76	8	by	by	ADP
ecletica-1173	76	9	the	the	DET
ecletica-1173	76	10	choice	choice	NOUN
ecletica-1173	76	11	of	of	ADP
ecletica-1173	76	12	a	a	DET
ecletica-1173	76	13	biological	biological	ADJ
ecletica-1173	76	14	target	target	NOUN
ecletica-1173	76	15	.	.	PUNCT
ecletica-1173	77	1	this	this	DET
ecletica-1173	77	2	biological	biological	ADJ
ecletica-1173	77	3	target	target	NOUN
ecletica-1173	77	4	can	can	AUX
ecletica-1173	77	5	be	be	AUX
ecletica-1173	77	6	known	know	VERB
ecletica-1173	77	7	or	or	CCONJ
ecletica-1173	77	8	created	create	VERB
ecletica-1173	77	9	by	by	ADP
ecletica-1173	77	10	sequencing	sequence	VERB
ecletica-1173	77	11	the	the	DET
ecletica-1173	77	12	amino	amino	NOUN
ecletica-1173	77	13	acids	acid	NOUN
ecletica-1173	77	14	.	.	PUNCT
ecletica-1173	78	1	the	the	DET
ecletica-1173	78	2	elucidation	elucidation	NOUN
ecletica-1173	78	3	of	of	ADP
ecletica-1173	78	4	molecular	molecular	ADJ
ecletica-1173	78	5	structure	structure	NOUN
ecletica-1173	78	6	will	will	AUX
ecletica-1173	78	7	allow	allow	VERB
ecletica-1173	78	8	the	the	DET
ecletica-1173	78	9	comprehension	comprehension	NOUN
ecletica-1173	78	10	of	of	ADP
ecletica-1173	78	11	the	the	DET
ecletica-1173	78	12	interaction	interaction	NOUN
ecletica-1173	78	13	between	between	ADP
ecletica-1173	78	14	the	the	DET
ecletica-1173	78	15	biological	biological	ADJ
ecletica-1173	78	16	target	target	NOUN
ecletica-1173	78	17	with	with	ADP
ecletica-1173	78	18	the	the	DET
ecletica-1173	78	19	substrates	substrate	NOUN
ecletica-1173	78	20	.	.	PUNCT
ecletica-1173	79	1	subsequently	subsequently	ADV
ecletica-1173	79	2	,	,	PUNCT
ecletica-1173	79	3	the	the	DET
ecletica-1173	79	4	electronic	electronic	ADJ
ecletica-1173	79	5	structure	structure	NOUN
ecletica-1173	79	6	and	and	CCONJ
ecletica-1173	79	7	molecular	molecular	ADJ
ecletica-1173	79	8	mechanical	mechanical	ADJ
ecletica-1173	79	9	calculations	calculation	NOUN
ecletica-1173	79	10	will	will	AUX
ecletica-1173	79	11	be	be	AUX
ecletica-1173	79	12	used	use	VERB
ecletica-1173	79	13	to	to	PART
ecletica-1173	79	14	understand	understand	VERB
ecletica-1173	79	15	the	the	DET
ecletica-1173	79	16	enzymatic	enzymatic	ADJ
ecletica-1173	79	17	active	active	ADJ
ecletica-1173	79	18	site	site	NOUN
ecletica-1173	79	19	.	.	PUNCT
ecletica-1173	80	1	molecular	molecular	ADJ
ecletica-1173	80	2	docking	docking	NOUN
ecletica-1173	80	3	is	be	AUX
ecletica-1173	80	4	used	use	VERB
ecletica-1173	80	5	to	to	PART
ecletica-1173	80	6	generate	generate	VERB
ecletica-1173	80	7	a	a	DET
ecletica-1173	80	8	set	set	NOUN
ecletica-1173	80	9	of	of	ADP
ecletica-1173	80	10	conformations	conformation	NOUN
ecletica-1173	80	11	inside	inside	ADP
ecletica-1173	80	12	the	the	DET
ecletica-1173	80	13	catalytic	catalytic	ADJ
ecletica-1173	80	14	site	site	NOUN
ecletica-1173	80	15	.	.	PUNCT
ecletica-1173	81	1	the	the	DET
ecletica-1173	81	2	comprehension	comprehension	NOUN
ecletica-1173	81	3	about	about	ADP
ecletica-1173	81	4	the	the	DET
ecletica-1173	81	5	catalytic	catalytic	ADJ
ecletica-1173	81	6	site	site	NOUN
ecletica-1173	81	7	will	will	AUX
ecletica-1173	81	8	identify	identify	VERB
ecletica-1173	81	9	which	which	DET
ecletica-1173	81	10	amino	amino	ADJ
ecletica-1173	81	11	acids	acid	NOUN
ecletica-1173	81	12	interact	interact	VERB
ecletica-1173	81	13	with	with	ADP
ecletica-1173	81	14	the	the	DET
ecletica-1173	81	15	possible	possible	ADJ
ecletica-1173	81	16	drug	drug	NOUN
ecletica-1173	81	17	.	.	PUNCT
ecletica-1173	82	1	in	in	ADP
ecletica-1173	82	2	this	this	DET
ecletica-1173	82	3	stage	stage	NOUN
ecletica-1173	82	4	,	,	PUNCT
ecletica-1173	82	5	the	the	DET
ecletica-1173	82	6	theoretical	theoretical	ADJ
ecletica-1173	82	7	approaches	approach	NOUN
ecletica-1173	82	8	will	will	AUX
ecletica-1173	82	9	help	help	VERB
ecletica-1173	82	10	to	to	PART
ecletica-1173	82	11	establish	establish	VERB
ecletica-1173	82	12	the	the	DET
ecletica-1173	82	13	most	most	ADV
ecletica-1173	82	14	important	important	ADJ
ecletica-1173	82	15	hydrogen	hydrogen	NOUN
ecletica-1173	82	16	bonds	bond	NOUN
ecletica-1173	82	17	,	,	PUNCT
ecletica-1173	82	18	pi	pi	NOUN
ecletica-1173	82	19	stacking	stack	VERB
ecletica-1173	82	20	interactions	interaction	NOUN
ecletica-1173	82	21	,	,	PUNCT
ecletica-1173	82	22	ion	ion	NOUN
ecletica-1173	82	23	interaction	interaction	NOUN
ecletica-1173	82	24	and	and	CCONJ
ecletica-1173	82	25	induced	induced	ADJ
ecletica-1173	82	26	dipole	dipole	NOUN
ecletica-1173	82	27	interactions	interaction	NOUN
ecletica-1173	82	28	.	.	PUNCT
ecletica-1173	83	1	the	the	DET
ecletica-1173	83	2	bind	bind	NOUN
ecletica-1173	83	3	energy	energy	NOUN
ecletica-1173	83	4	can	can	AUX
ecletica-1173	83	5	be	be	AUX
ecletica-1173	83	6	calculated	calculate	VERB
ecletica-1173	83	7	using	use	VERB
ecletica-1173	83	8	classical	classical	ADJ
ecletica-1173	83	9	force	force	NOUN
ecletica-1173	83	10	fields	field	NOUN
ecletica-1173	83	11	or	or	CCONJ
ecletica-1173	83	12	quantum	quantum	NOUN
ecletica-1173	83	13	mechanics	mechanic	NOUN
ecletica-1173	83	14	/	/	SYM
ecletica-1173	83	15	molecular	molecular	ADJ
ecletica-1173	83	16	mechanics	mechanic	NOUN
ecletica-1173	83	17	(	(	PUNCT
ecletica-1173	83	18	qm	qm	PROPN
ecletica-1173	83	19	/	/	SYM
ecletica-1173	83	20	mm	mm	PROPN
ecletica-1173	83	21	)	)	PUNCT
ecletica-1173	83	22	approaches	approach	NOUN
ecletica-1173	83	23	.	.	PUNCT
ecletica-1173	84	1	next	next	ADJ
ecletica-1173	84	2	step	step	NOUN
ecletica-1173	84	3	is	be	AUX
ecletica-1173	84	4	to	to	PART
ecletica-1173	84	5	start	start	VERB
ecletica-1173	84	6	the	the	DET
ecletica-1173	84	7	synthesis	synthesis	NOUN
ecletica-1173	84	8	of	of	ADP
ecletica-1173	84	9	the	the	DET
ecletica-1173	84	10	drug	drug	NOUN
ecletica-1173	84	11	candidate	candidate	NOUN
ecletica-1173	84	12	.	.	PUNCT
ecletica-1173	85	1	then	then	ADV
ecletica-1173	85	2	,	,	PUNCT
ecletica-1173	85	3	this	this	DET
ecletica-1173	85	4	molecule	molecule	NOUN
ecletica-1173	85	5	may	may	AUX
ecletica-1173	85	6	be	be	AUX
ecletica-1173	85	7	assayed	assayed	ADJ
ecletica-1173	85	8	on	on	ADP
ecletica-1173	85	9	in	in	ADP
ecletica-1173	85	10	vitro	vitro	X
ecletica-1173	85	11	enzymes	enzyme	NOUN
ecletica-1173	85	12	,	,	PUNCT
ecletica-1173	85	13	for	for	ADP
ecletica-1173	85	14	example	example	NOUN
ecletica-1173	85	15	.	.	PUNCT
ecletica-1173	86	1	this	this	PRON
ecletica-1173	86	2	is	be	AUX
ecletica-1173	86	3	a	a	DET
ecletica-1173	86	4	brief	brief	ADJ
ecletica-1173	86	5	summary	summary	NOUN
ecletica-1173	86	6	of	of	ADP
ecletica-1173	86	7	the	the	DET
ecletica-1173	86	8	well	well	ADV
ecletica-1173	86	9	-	-	PUNCT
ecletica-1173	86	10	known	know	VERB
ecletica-1173	86	11	“	"	PUNCT
ecletica-1173	86	12	rational	rational	ADJ
ecletica-1173	86	13	”	"	PUNCT
ecletica-1173	86	14	design	design	NOUN
ecletica-1173	86	15	of	of	ADP
ecletica-1173	86	16	new	new	ADJ
ecletica-1173	86	17	drugs	drug	NOUN
ecletica-1173	86	18	.	.	PUNCT
ecletica-1173	87	1	in	in	ADP
ecletica-1173	87	2	the	the	DET
ecletica-1173	87	3	manuscript	manuscript	NOUN
ecletica-1173	87	4	,	,	PUNCT
ecletica-1173	87	5	it	it	PRON
ecletica-1173	87	6	will	will	AUX
ecletica-1173	87	7	be	be	AUX
ecletica-1173	87	8	shown	show	VERB
ecletica-1173	87	9	that	that	SCONJ
ecletica-1173	87	10	the	the	DET
ecletica-1173	87	11	idea	idea	NOUN
ecletica-1173	87	12	behind	behind	ADP
ecletica-1173	87	13	the	the	DET
ecletica-1173	87	14	rational	rational	ADJ
ecletica-1173	87	15	design	design	NOUN
ecletica-1173	87	16	of	of	ADP
ecletica-1173	87	17	drugs	drug	NOUN
ecletica-1173	87	18	starts	start	VERB
ecletica-1173	87	19	from	from	ADP
ecletica-1173	87	20	ontological	ontological	ADJ
ecletica-1173	87	21	reductionism	reductionism	NOUN
ecletica-1173	87	22	,	,	PUNCT
ecletica-1173	87	23	which	which	PRON
ecletica-1173	87	24	does	do	AUX
ecletica-1173	87	25	not	not	PART
ecletica-1173	87	26	cover	cover	VERB
ecletica-1173	87	27	the	the	DET
ecletica-1173	87	28	whole	whole	ADJ
ecletica-1173	87	29	problem	problem	NOUN
ecletica-1173	87	30	to	to	PART
ecletica-1173	87	31	be	be	AUX
ecletica-1173	87	32	solved	solve	VERB
ecletica-1173	87	33	.	.	PUNCT
ecletica-1173	88	1	4	4	X
ecletica-1173	88	2	.	.	X
ecletica-1173	88	3	the	the	DET
ecletica-1173	88	4	origin	origin	NOUN
ecletica-1173	88	5	of	of	ADP
ecletica-1173	88	6	biological	biological	ADJ
ecletica-1173	88	7	reductionism	reductionism	NOUN
ecletica-1173	88	8	the	the	DET
ecletica-1173	88	9	discussion	discussion	NOUN
ecletica-1173	88	10	about	about	ADP
ecletica-1173	88	11	reductionism	reductionism	NOUN
ecletica-1173	88	12	in	in	ADP
ecletica-1173	88	13	different	different	ADJ
ecletica-1173	88	14	meanings	meaning	NOUN
ecletica-1173	88	15	can	can	AUX
ecletica-1173	88	16	be	be	AUX
ecletica-1173	88	17	observed	observe	VERB
ecletica-1173	88	18	in	in	ADP
ecletica-1173	88	19	the	the	DET
ecletica-1173	88	20	declarations	declaration	NOUN
ecletica-1173	88	21	below	below	ADV
ecletica-1173	88	22	.	.	PUNCT
ecletica-1173	89	1	crick	crick	NOUN
ecletica-1173	89	2	(	(	PUNCT
ecletica-1173	89	3	1966	1966	NUM
ecletica-1173	89	4	)	)	PUNCT
ecletica-1173	89	5	claims	claim	VERB
ecletica-1173	89	6	that	that	SCONJ
ecletica-1173	89	7	“	"	PUNCT
ecletica-1173	89	8	the	the	DET
ecletica-1173	89	9	ultimate	ultimate	ADJ
ecletica-1173	89	10	aim	aim	NOUN
ecletica-1173	89	11	of	of	ADP
ecletica-1173	89	12	the	the	DET
ecletica-1173	89	13	modern	modern	ADJ
ecletica-1173	89	14	movement	movement	NOUN
ecletica-1173	89	15	in	in	ADP
ecletica-1173	89	16	biology	biology	NOUN
ecletica-1173	89	17	is	be	AUX
ecletica-1173	89	18	to	to	PART
ecletica-1173	89	19	explain	explain	VERB
ecletica-1173	89	20	all	all	DET
ecletica-1173	89	21	biology	biology	NOUN
ecletica-1173	89	22	in	in	ADP
ecletica-1173	89	23	terms	term	NOUN
ecletica-1173	89	24	of	of	ADP
ecletica-1173	89	25	physics	physics	NOUN
ecletica-1173	89	26	and	and	CCONJ
ecletica-1173	89	27	chemistry	chemistry	NOUN
ecletica-1173	89	28	”	"	PUNCT
ecletica-1173	89	29	.	.	PUNCT
ecletica-1173	90	1	this	this	DET
ecletica-1173	90	2	approach	approach	NOUN
ecletica-1173	90	3	epitomizes	epitomize	VERB
ecletica-1173	90	4	the	the	DET
ecletica-1173	90	5	reductionist	reductionist	ADJ
ecletica-1173	90	6	mindset	mindset	NOUN
ecletica-1173	90	7	that	that	PRON
ecletica-1173	90	8	has	have	AUX
ecletica-1173	90	9	permeated	permeate	VERB
ecletica-1173	90	10	molecular	molecular	ADJ
ecletica-1173	90	11	biology	biology	NOUN
ecletica-1173	90	12	for	for	ADP
ecletica-1173	90	13	half	half	DET
ecletica-1173	90	14	a	a	DET
ecletica-1173	90	15	century	century	NOUN
ecletica-1173	90	16	.	.	PUNCT
ecletica-1173	91	1	the	the	DET
ecletica-1173	91	2	most	most	ADV
ecletica-1173	91	3	extreme	extreme	ADJ
ecletica-1173	91	4	manifestation	manifestation	NOUN
ecletica-1173	91	5	of	of	ADP
ecletica-1173	91	6	the	the	DET
ecletica-1173	91	7	reductionist	reductionist	ADJ
ecletica-1173	91	8	view	view	NOUN
ecletica-1173	91	9	is	be	AUX
ecletica-1173	91	10	the	the	DET
ecletica-1173	91	11	belief	belief	NOUN
ecletica-1173	91	12	that	that	PRON
ecletica-1173	91	13	is	be	AUX
ecletica-1173	91	14	held	hold	VERB
ecletica-1173	91	15	by	by	ADP
ecletica-1173	91	16	some	some	DET
ecletica-1173	91	17	neuroscientists	neuroscientist	NOUN
ecletica-1173	91	18	that	that	SCONJ
ecletica-1173	91	19	consciousness	consciousness	NOUN
ecletica-1173	91	20	and	and	CCONJ
ecletica-1173	91	21	mental	mental	ADJ
ecletica-1173	91	22	states	state	NOUN
ecletica-1173	91	23	can	can	AUX
ecletica-1173	91	24	be	be	AUX
ecletica-1173	91	25	reduced	reduce	VERB
ecletica-1173	91	26	to	to	ADP
ecletica-1173	91	27	chemical	chemical	ADJ
ecletica-1173	91	28	reactions	reaction	NOUN
ecletica-1173	91	29	that	that	PRON
ecletica-1173	91	30	occur	occur	VERB
ecletica-1173	91	31	in	in	ADP
ecletica-1173	91	32	the	the	DET
ecletica-1173	91	33	brain	brain	NOUN
ecletica-1173	91	34	.	.	PUNCT
ecletica-1173	92	1	the	the	DET
ecletica-1173	92	2	epistemological	epistemological	ADJ
ecletica-1173	92	3	reductionism	reductionism	NOUN
ecletica-1173	92	4	can	can	AUX
ecletica-1173	92	5	be	be	AUX
ecletica-1173	92	6	observed	observe	VERB
ecletica-1173	92	7	in	in	ADP
ecletica-1173	92	8	the	the	DET
ecletica-1173	92	9	words	word	NOUN
ecletica-1173	92	10	of	of	ADP
ecletica-1173	92	11	crick	crick	NOUN
ecletica-1173	92	12	(	(	PUNCT
ecletica-1173	92	13	1966	1966	NUM
ecletica-1173	92	14	)	)	PUNCT
ecletica-1173	92	15	.	.	PUNCT
ecletica-1173	93	1	the	the	DET
ecletica-1173	93	2	domain	domain	NOUN
ecletica-1173	93	3	of	of	ADP
ecletica-1173	93	4	biology	biology	NOUN
ecletica-1173	93	5	is	be	AUX
ecletica-1173	93	6	reduced	reduce	VERB
ecletica-1173	93	7	to	to	ADP
ecletica-1173	93	8	chemical	chemical	ADJ
ecletica-1173	93	9	reactions	reaction	NOUN
ecletica-1173	93	10	.	.	PUNCT
ecletica-1173	94	1	it	it	PRON
ecletica-1173	94	2	could	could	AUX
ecletica-1173	94	3	be	be	AUX
ecletica-1173	94	4	possible	possible	ADJ
ecletica-1173	94	5	to	to	PART
ecletica-1173	94	6	predict	predict	VERB
ecletica-1173	94	7	biological	biological	ADJ
ecletica-1173	94	8	phenomena	phenomenon	NOUN
ecletica-1173	94	9	due	due	ADP
ecletica-1173	94	10	to	to	ADP
ecletica-1173	94	11	specific	specific	ADJ
ecletica-1173	94	12	chemical	chemical	NOUN
ecletica-1173	94	13	reactions	reaction	NOUN
ecletica-1173	94	14	.	.	PUNCT
ecletica-1173	95	1	on	on	ADP
ecletica-1173	95	2	the	the	DET
ecletica-1173	95	3	other	other	ADJ
ecletica-1173	95	4	hand	hand	NOUN
ecletica-1173	95	5	,	,	PUNCT
ecletica-1173	95	6	paul	paul	PROPN
ecletica-1173	95	7	nurse	nurse	PROPN
ecletica-1173	95	8	criticized	criticize	VERB
ecletica-1173	95	9	the	the	DET
ecletica-1173	95	10	reductionism	reductionism	NOUN
ecletica-1173	95	11	defended	defend	VERB
ecletica-1173	95	12	by	by	ADP
ecletica-1173	95	13	crick	crick	NOUN
ecletica-1173	95	14	and	and	CCONJ
ecletica-1173	95	15	other	other	ADJ
ecletica-1173	95	16	scientists	scientist	NOUN
ecletica-1173	95	17	.	.	PUNCT
ecletica-1173	96	1	nurse	nurse	PROPN
ecletica-1173	96	2	(	(	PUNCT
ecletica-1173	96	3	1997	1997	NUM
ecletica-1173	96	4	)	)	PUNCT
ecletica-1173	96	5	begins	begin	VERB
ecletica-1173	96	6	his	his	PRON
ecletica-1173	96	7	writing	writing	NOUN
ecletica-1173	96	8	in	in	ADP
ecletica-1173	96	9	nature	nature	NOUN
ecletica-1173	96	10	with	with	ADP
ecletica-1173	96	11	a	a	DET
ecletica-1173	96	12	reductionist	reductionist	ADJ
ecletica-1173	96	13	question	question	NOUN
ecletica-1173	96	14	:	:	PUNCT
ecletica-1173	96	15	“	"	PUNCT
ecletica-1173	96	16	if	if	SCONJ
ecletica-1173	96	17	we	we	PRON
ecletica-1173	96	18	had	have	VERB
ecletica-1173	96	19	knowledge	knowledge	NOUN
ecletica-1173	96	20	of	of	ADP
ecletica-1173	96	21	all	all	DET
ecletica-1173	96	22	the	the	DET
ecletica-1173	96	23	molecular	molecular	ADJ
ecletica-1173	96	24	reactions	reaction	NOUN
ecletica-1173	96	25	that	that	PRON
ecletica-1173	96	26	take	take	VERB
ecletica-1173	96	27	place	place	NOUN
ecletica-1173	96	28	within	within	ADP
ecletica-1173	96	29	the	the	DET
ecletica-1173	96	30	cell	cell	NOUN
ecletica-1173	96	31	,	,	PUNCT
ecletica-1173	96	32	would	would	AUX
ecletica-1173	96	33	we	we	PRON
ecletica-1173	96	34	know	know	VERB
ecletica-1173	96	35	the	the	DET
ecletica-1173	96	36	cell	cell	NOUN
ecletica-1173	96	37	?	?	PUNCT
ecletica-1173	96	38	”	"	PUNCT
ecletica-1173	97	1	the	the	DET
ecletica-1173	97	2	article	article	NOUN
ecletica-1173	97	3	comes	come	VERB
ecletica-1173	97	4	up	up	ADP
ecletica-1173	97	5	with	with	ADP
ecletica-1173	97	6	the	the	DET
ecletica-1173	97	7	following	follow	VERB
ecletica-1173	97	8	answer	answer	NOUN
ecletica-1173	97	9	:	:	PUNCT
ecletica-1173	97	10	“	"	PUNCT
ecletica-1173	97	11	explanations	explanation	NOUN
ecletica-1173	97	12	in	in	ADP
ecletica-1173	97	13	science	science	NOUN
ecletica-1173	97	14	must	must	AUX
ecletica-1173	97	15	always	always	ADV
ecletica-1173	97	16	have	have	VERB
ecletica-1173	97	17	some	some	DET
ecletica-1173	97	18	elements	element	NOUN
ecletica-1173	97	19	of	of	ADP
ecletica-1173	97	20	reductionism	reductionism	NOUN
ecletica-1173	97	21	,	,	PUNCT
ecletica-1173	97	22	but	but	CCONJ
ecletica-1173	97	23	descriptions	description	NOUN
ecletica-1173	97	24	of	of	ADP
ecletica-1173	97	25	increasing	increase	VERB
ecletica-1173	97	26	detail	detail	NOUN
ecletica-1173	97	27	may	may	AUX
ecletica-1173	97	28	only	only	ADV
ecletica-1173	97	29	provide	provide	VERB
ecletica-1173	97	30	a	a	DET
ecletica-1173	97	31	delusion	delusion	NOUN
ecletica-1173	97	32	of	of	ADP
ecletica-1173	97	33	understanding	understanding	NOUN
ecletica-1173	97	34	;	;	PUNCT
ecletica-1173	97	35	overenthusiastic	overenthusiastic	ADJ
ecletica-1173	97	36	pursuit	pursuit	NOUN
ecletica-1173	97	37	of	of	ADP
ecletica-1173	97	38	reductionism	reductionism	NOUN
ecletica-1173	97	39	can	can	AUX
ecletica-1173	97	40	limit	limit	VERB
ecletica-1173	97	41	discovery	discovery	NOUN
ecletica-1173	97	42	and	and	CCONJ
ecletica-1173	97	43	also	also	ADV
ecletica-1173	97	44	has	have	VERB
ecletica-1173	97	45	ideological	ideological	ADJ
ecletica-1173	97	46	implications	implication	NOUN
ecletica-1173	97	47	in	in	ADP
ecletica-1173	97	48	defining	define	VERB
ecletica-1173	97	49	what	what	PRON
ecletica-1173	97	50	is	be	AUX
ecletica-1173	97	51	considered	consider	VERB
ecletica-1173	97	52	to	to	PART
ecletica-1173	97	53	be	be	AUX
ecletica-1173	97	54	the	the	DET
ecletica-1173	97	55	best	good	ADJ
ecletica-1173	97	56	science	science	NOUN
ecletica-1173	97	57	in	in	ADP
ecletica-1173	97	58	terms	term	NOUN
ecletica-1173	97	59	of	of	ADP
ecletica-1173	97	60	publication	publication	NOUN
ecletica-1173	97	61	and	and	CCONJ
ecletica-1173	97	62	financial	financial	ADJ
ecletica-1173	97	63	support	support	NOUN
ecletica-1173	97	64	...	...	PUNCT
ecletica-1173	97	65	”	"	PUNCT
ecletica-1173	97	66	however	however	ADV
ecletica-1173	97	67	,	,	PUNCT
ecletica-1173	97	68	there	there	PRON
ecletica-1173	97	69	is	be	VERB
ecletica-1173	97	70	a	a	DET
ecletica-1173	97	71	real	real	ADJ
ecletica-1173	97	72	problem	problem	NOUN
ecletica-1173	97	73	to	to	PART
ecletica-1173	97	74	define	define	VERB
ecletica-1173	97	75	what	what	PRON
ecletica-1173	97	76	is	be	AUX
ecletica-1173	97	77	an	an	DET
ecletica-1173	97	78	enough	enough	ADJ
ecletica-1173	97	79	explanation	explanation	NOUN
ecletica-1173	97	80	.	.	PUNCT
ecletica-1173	98	1	there	there	PRON
ecletica-1173	98	2	are	be	VERB
ecletica-1173	98	3	many	many	ADJ
ecletica-1173	98	4	philosophers	philosopher	NOUN
ecletica-1173	98	5	who	who	PRON
ecletica-1173	98	6	believe	believe	VERB
ecletica-1173	98	7	that	that	SCONJ
ecletica-1173	98	8	there	there	PRON
ecletica-1173	98	9	is	be	VERB
ecletica-1173	98	10	a	a	DET
ecletica-1173	98	11	reduction	reduction	NOUN
ecletica-1173	98	12	from	from	ADP
ecletica-1173	98	13	causality	causality	NOUN
ecletica-1173	98	14	at	at	ADP
ecletica-1173	98	15	the	the	DET
ecletica-1173	98	16	macro	macro	ADJ
ecletica-1173	98	17	level	level	NOUN
ecletica-1173	98	18	to	to	ADP
ecletica-1173	98	19	causality	causality	NOUN
ecletica-1173	98	20	at	at	ADP
ecletica-1173	98	21	the	the	DET
ecletica-1173	98	22	micro	micro	ADJ
ecletica-1173	98	23	level	level	NOUN
ecletica-1173	98	24	.	.	PUNCT
ecletica-1173	99	1	menzies	menzie	NOUN
ecletica-1173	99	2	(	(	PUNCT
ecletica-1173	99	3	1988	1988	NUM
ecletica-1173	99	4	)	)	PUNCT
ecletica-1173	99	5	calls	call	VERB
ecletica-1173	99	6	this	this	DET
ecletica-1173	99	7	idea	idea	NOUN
ecletica-1173	99	8	causal	causal	NOUN
ecletica-1173	99	9	reductionism	reductionism	NOUN
ecletica-1173	99	10	.	.	PUNCT
ecletica-1173	100	1	reducing	reduce	VERB
ecletica-1173	100	2	causal	causal	ADJ
ecletica-1173	100	3	relationships	relationship	NOUN
ecletica-1173	100	4	from	from	ADP
ecletica-1173	100	5	macro	macro	ADJ
ecletica-1173	100	6	to	to	ADP
ecletica-1173	100	7	micro	micro	ADJ
ecletica-1173	100	8	levels	level	NOUN
ecletica-1173	100	9	presupposes	presuppose	VERB
ecletica-1173	100	10	some	some	DET
ecletica-1173	100	11	way	way	NOUN
ecletica-1173	100	12	to	to	PART
ecletica-1173	100	13	correlate	correlate	VERB
ecletica-1173	100	14	the	the	DET
ecletica-1173	100	15	events	event	NOUN
ecletica-1173	100	16	that	that	PRON
ecletica-1173	100	17	have	have	VERB
ecletica-1173	100	18	causation	causation	NOUN
ecletica-1173	100	19	effect	effect	NOUN
ecletica-1173	100	20	at	at	ADP
ecletica-1173	100	21	different	different	ADJ
ecletica-1173	100	22	levels	level	NOUN
ecletica-1173	100	23	.	.	PUNCT
ecletica-1173	101	1	ontological	ontological	ADJ
ecletica-1173	101	2	reductionism	reductionism	NOUN
ecletica-1173	101	3	analyzes	analyze	VERB
ecletica-1173	101	4	the	the	DET
ecletica-1173	101	5	whole	whole	NOUN
ecletica-1173	101	6	in	in	ADP
ecletica-1173	101	7	parts	part	NOUN
ecletica-1173	101	8	and	and	CCONJ
ecletica-1173	101	9	decides	decide	VERB
ecletica-1173	101	10	the	the	DET
ecletica-1173	101	11	associations	association	NOUN
ecletica-1173	101	12	between	between	ADP
ecletica-1173	101	13	the	the	DET
ecletica-1173	101	14	parts	part	NOUN
ecletica-1173	101	15	.	.	PUNCT
ecletica-1173	102	1	this	this	DET
ecletica-1173	102	2	approach	approach	NOUN
ecletica-1173	102	3	accepts	accept	VERB
ecletica-1173	102	4	that	that	SCONJ
ecletica-1173	102	5	only	only	ADV
ecletica-1173	102	6	the	the	DET
ecletica-1173	102	7	molecules	molecule	NOUN
ecletica-1173	102	8	supply	supply	VERB
ecletica-1173	102	9	a	a	DET
ecletica-1173	102	10	comprehension	comprehension	NOUN
ecletica-1173	102	11	of	of	ADP
ecletica-1173	102	12	the	the	DET
ecletica-1173	102	13	entire	entire	ADJ
ecletica-1173	102	14	system	system	NOUN
ecletica-1173	102	15	.	.	PUNCT
ecletica-1173	103	1	currently	currently	ADV
ecletica-1173	103	2	,	,	PUNCT
ecletica-1173	103	3	it	it	PRON
ecletica-1173	103	4	is	be	AUX
ecletica-1173	103	5	evident	evident	ADJ
ecletica-1173	103	6	that	that	SCONJ
ecletica-1173	103	7	the	the	DET
ecletica-1173	103	8	specificity	specificity	NOUN
ecletica-1173	103	9	of	of	ADP
ecletica-1173	103	10	a	a	DET
ecletica-1173	103	11	complex	complex	ADJ
ecletica-1173	103	12	biological	biological	ADJ
ecletica-1173	103	13	activity	activity	NOUN
ecletica-1173	103	14	does	do	AUX
ecletica-1173	103	15	not	not	PART
ecletica-1173	103	16	emerge	emerge	VERB
ecletica-1173	103	17	from	from	ADP
ecletica-1173	103	18	the	the	DET
ecletica-1173	103	19	properties	property	NOUN
ecletica-1173	103	20	of	of	ADP
ecletica-1173	103	21	the	the	DET
ecletica-1173	103	22	individual	individual	ADJ
ecletica-1173	103	23	molecules	molecule	NOUN
ecletica-1173	103	24	.	.	PUNCT
ecletica-1173	104	1	this	this	DET
ecletica-1173	104	2	molecular	molecular	ADJ
ecletica-1173	104	3	http://revista.iq.unesp.br/ojs/index.php/ecletica/index	http://revista.iq.unesp.br/ojs/index.php/ecletica/index	NOUN
ecletica-1173	104	4	https://doi.org/10.26850/1678-4618eqj.v46.3.2021.p17-32	https://doi.org/10.26850/1678-4618eqj.v46.3.2021.p17-32	PROPN
ecletica-1173	104	5	review	review	NOUN
ecletica-1173	104	6	article	article	NOUN
ecletica-1173	104	7	iq.unesp.br/ecletica	iq.unesp.br/ecletica	PROPN
ecletica-1173	104	8	20	20	NUM
ecletica-1173	104	9	eclética	eclética	PROPN
ecletica-1173	104	10	química	química	PROPN
ecletica-1173	104	11	journal	journal	PROPN
ecletica-1173	104	12	,	,	PUNCT
ecletica-1173	104	13	vol	vol	NOUN
ecletica-1173	104	14	.	.	PROPN
ecletica-1173	104	15	46	46	NUM
ecletica-1173	104	16	,	,	PUNCT
ecletica-1173	104	17	n.	n.	NOUN
ecletica-1173	104	18	3	3	NUM
ecletica-1173	104	19	,	,	PUNCT
ecletica-1173	104	20	2021	2021	NUM
ecletica-1173	104	21	,	,	PUNCT
ecletica-1173	104	22	17	17	NUM
ecletica-1173	104	23	-	-	SYM
ecletica-1173	104	24	32	32	NUM
ecletica-1173	104	25	issn	issn	NOUN
ecletica-1173	104	26	:	:	PUNCT
ecletica-1173	104	27	1678	1678	NUM
ecletica-1173	104	28	-	-	SYM
ecletica-1173	104	29	4618	4618	NUM
ecletica-1173	104	30	doi	doi	NOUN
ecletica-1173	104	31	:	:	PUNCT
ecletica-1173	104	32	10.26850/1678	10.26850/1678	NUM
ecletica-1173	104	33	-	-	SYM
ecletica-1173	104	34	4618eqj.v46.3.2021.p17	4618eqj.v46.3.2021.p17	NOUN
ecletica-1173	104	35	-	-	SYM
ecletica-1173	104	36	32	32	NUM
ecletica-1173	104	37	structure	structure	NOUN
ecletica-1173	104	38	constantly	constantly	ADV
ecletica-1173	104	39	works	work	VERB
ecletica-1173	104	40	in	in	ADP
ecletica-1173	104	41	numerous	numerous	ADJ
ecletica-1173	104	42	distinctive	distinctive	ADJ
ecletica-1173	104	43	forms	form	NOUN
ecletica-1173	104	44	(	(	PUNCT
ecletica-1173	104	45	nicholson	nicholson	PROPN
ecletica-1173	104	46	,	,	PUNCT
ecletica-1173	104	47	2019	2019	NUM
ecletica-1173	104	48	;	;	PUNCT
ecletica-1173	104	49	pierce	pierce	PROPN
ecletica-1173	104	50	junior	junior	PROPN
ecletica-1173	104	51	et	et	PROPN
ecletica-1173	104	52	al	al	PROPN
ecletica-1173	104	53	.	.	PROPN
ecletica-1173	104	54	,	,	PUNCT
ecletica-1173	104	55	1960	1960	NUM
ecletica-1173	104	56	)	)	PUNCT
ecletica-1173	104	57	.	.	PUNCT
ecletica-1173	105	1	there	there	PRON
ecletica-1173	105	2	are	be	VERB
ecletica-1173	105	3	yet	yet	ADV
ecletica-1173	105	4	studies	study	NOUN
ecletica-1173	105	5	that	that	PRON
ecletica-1173	105	6	lead	lead	VERB
ecletica-1173	105	7	to	to	ADP
ecletica-1173	105	8	a	a	DET
ecletica-1173	105	9	holistic	holistic	ADJ
ecletica-1173	105	10	view	view	NOUN
ecletica-1173	105	11	for	for	ADP
ecletica-1173	105	12	the	the	DET
ecletica-1173	105	13	treatment	treatment	NOUN
ecletica-1173	105	14	of	of	ADP
ecletica-1173	105	15	certain	certain	ADJ
ecletica-1173	105	16	types	type	NOUN
ecletica-1173	105	17	of	of	ADP
ecletica-1173	105	18	disease	disease	NOUN
ecletica-1173	105	19	(	(	PUNCT
ecletica-1173	105	20	birkbak	birkbak	NOUN
ecletica-1173	105	21	and	and	CCONJ
ecletica-1173	105	22	mcgranahan	mcgranahan	PROPN
ecletica-1173	105	23	,	,	PUNCT
ecletica-1173	105	24	2020	2020	NUM
ecletica-1173	105	25	;	;	PUNCT
ecletica-1173	105	26	nicholson	nicholson	PROPN
ecletica-1173	105	27	,	,	PUNCT
ecletica-1173	105	28	2019	2019	NUM
ecletica-1173	105	29	;	;	PUNCT
ecletica-1173	105	30	pierce	pierce	PROPN
ecletica-1173	105	31	junior	junior	PROPN
ecletica-1173	105	32	et	et	PROPN
ecletica-1173	105	33	al	al	PROPN
ecletica-1173	105	34	.	.	PROPN
ecletica-1173	105	35	,	,	PUNCT
ecletica-1173	105	36	1960	1960	NUM
ecletica-1173	105	37	)	)	PUNCT
ecletica-1173	105	38	.	.	PUNCT
ecletica-1173	106	1	the	the	DET
ecletica-1173	106	2	cancer	cancer	NOUN
ecletica-1173	106	3	treatment	treatment	NOUN
ecletica-1173	106	4	is	be	AUX
ecletica-1173	106	5	a	a	DET
ecletica-1173	106	6	particularly	particularly	ADV
ecletica-1173	106	7	interesting	interesting	ADJ
ecletica-1173	106	8	case	case	NOUN
ecletica-1173	106	9	.	.	PUNCT
ecletica-1173	107	1	cancer	cancer	NOUN
ecletica-1173	107	2	is	be	AUX
ecletica-1173	107	3	a	a	DET
ecletica-1173	107	4	disease	disease	NOUN
ecletica-1173	107	5	of	of	ADP
ecletica-1173	107	6	multifactorial	multifactorial	ADJ
ecletica-1173	107	7	origin	origin	NOUN
ecletica-1173	107	8	that	that	PRON
ecletica-1173	107	9	is	be	AUX
ecletica-1173	107	10	treated	treat	VERB
ecletica-1173	107	11	in	in	ADP
ecletica-1173	107	12	the	the	DET
ecletica-1173	107	13	context	context	NOUN
ecletica-1173	107	14	of	of	ADP
ecletica-1173	107	15	that	that	SCONJ
ecletica-1173	107	16	the	the	DET
ecletica-1173	107	17	problem	problem	NOUN
ecletica-1173	107	18	originated	originate	VERB
ecletica-1173	107	19	from	from	ADP
ecletica-1173	107	20	somatic	somatic	ADJ
ecletica-1173	107	21	mutations	mutation	NOUN
ecletica-1173	107	22	in	in	ADP
ecletica-1173	107	23	cells	cell	NOUN
ecletica-1173	107	24	.	.	PUNCT
ecletica-1173	108	1	barry	barry	PROPN
ecletica-1173	108	2	pierce	pierce	PROPN
ecletica-1173	108	3	and	and	CCONJ
ecletica-1173	108	4	his	his	PRON
ecletica-1173	108	5	colleagues	colleague	NOUN
ecletica-1173	108	6	showed	show	VERB
ecletica-1173	108	7	the	the	DET
ecletica-1173	108	8	differentiation	differentiation	NOUN
ecletica-1173	108	9	of	of	ADP
ecletica-1173	108	10	malignant	malignant	ADJ
ecletica-1173	108	11	neoplastic	neoplastic	ADJ
ecletica-1173	108	12	cells	cell	NOUN
ecletica-1173	108	13	into	into	ADP
ecletica-1173	108	14	benign	benign	ADJ
ecletica-1173	108	15	cell	cell	NOUN
ecletica-1173	108	16	types	type	NOUN
ecletica-1173	108	17	(	(	PUNCT
ecletica-1173	108	18	lok	lok	PROPN
ecletica-1173	108	19	,	,	PUNCT
ecletica-1173	108	20	2006	2006	NUM
ecletica-1173	108	21	;	;	PUNCT
ecletica-1173	108	22	pierce	pierce	PROPN
ecletica-1173	108	23	junior	junior	PROPN
ecletica-1173	108	24	et	et	PROPN
ecletica-1173	108	25	al	al	PROPN
ecletica-1173	108	26	.	.	PROPN
ecletica-1173	108	27	,	,	PUNCT
ecletica-1173	108	28	1960	1960	NUM
ecletica-1173	108	29	)	)	PUNCT
ecletica-1173	108	30	.	.	PUNCT
ecletica-1173	109	1	these	these	DET
ecletica-1173	109	2	researchers	researcher	NOUN
ecletica-1173	109	3	refuted	refute	VERB
ecletica-1173	109	4	the	the	DET
ecletica-1173	109	5	initial	initial	ADJ
ecletica-1173	109	6	dogma	dogma	NOUN
ecletica-1173	109	7	“	"	PUNCT
ecletica-1173	109	8	once	once	ADV
ecletica-1173	109	9	a	a	DET
ecletica-1173	109	10	cancer	cancer	NOUN
ecletica-1173	109	11	cell	cell	NOUN
ecletica-1173	109	12	,	,	PUNCT
ecletica-1173	109	13	always	always	ADV
ecletica-1173	109	14	a	a	DET
ecletica-1173	109	15	cancer	cancer	NOUN
ecletica-1173	109	16	cell	cell	NOUN
ecletica-1173	109	17	”	"	PUNCT
ecletica-1173	109	18	.	.	PUNCT
ecletica-1173	110	1	the	the	DET
ecletica-1173	110	2	microenvironment	microenvironment	ADJ
ecletica-1173	110	3	and	and	CCONJ
ecletica-1173	110	4	normal	normal	ADJ
ecletica-1173	110	5	tissue	tissue	NOUN
ecletica-1173	110	6	architectures	architecture	NOUN
ecletica-1173	110	7	may	may	AUX
ecletica-1173	110	8	restrict	restrict	VERB
ecletica-1173	110	9	tumor	tumor	NOUN
ecletica-1173	110	10	development	development	NOUN
ecletica-1173	110	11	,	,	PUNCT
ecletica-1173	110	12	but	but	CCONJ
ecletica-1173	110	13	otherwise	otherwise	ADV
ecletica-1173	110	14	may	may	AUX
ecletica-1173	110	15	also	also	ADV
ecletica-1173	110	16	promote	promote	VERB
ecletica-1173	110	17	and	and	CCONJ
ecletica-1173	110	18	induce	induce	VERB
ecletica-1173	110	19	cancer	cancer	NOUN
ecletica-1173	110	20	(	(	PUNCT
ecletica-1173	110	21	hagios	hagio	NOUN
ecletica-1173	110	22	et	et	NOUN
ecletica-1173	110	23	al	al	PROPN
ecletica-1173	110	24	.	.	PROPN
ecletica-1173	110	25	,	,	PUNCT
ecletica-1173	110	26	1998	1998	NUM
ecletica-1173	110	27	;	;	PUNCT
ecletica-1173	110	28	nci	nci	PROPN
ecletica-1173	110	29	,	,	PUNCT
ecletica-1173	110	30	2018	2018	NUM
ecletica-1173	110	31	)	)	PUNCT
ecletica-1173	110	32	.	.	PUNCT
ecletica-1173	111	1	a	a	DET
ecletica-1173	111	2	brief	brief	ADJ
ecletica-1173	111	3	survey	survey	NOUN
ecletica-1173	111	4	on	on	ADP
ecletica-1173	111	5	the	the	DET
ecletica-1173	111	6	page	page	NOUN
ecletica-1173	111	7	of	of	ADP
ecletica-1173	111	8	the	the	DET
ecletica-1173	111	9	national	national	PROPN
ecletica-1173	111	10	cancer	cancer	PROPN
ecletica-1173	111	11	institute	institute	PROPN
ecletica-1173	111	12	in	in	ADP
ecletica-1173	111	13	the	the	DET
ecletica-1173	111	14	united	united	PROPN
ecletica-1173	111	15	states	states	PROPN
ecletica-1173	111	16	(	(	PUNCT
ecletica-1173	111	17	manley	manley	PROPN
ecletica-1173	111	18	et	et	PROPN
ecletica-1173	111	19	al	al	PROPN
ecletica-1173	111	20	.	.	PROPN
ecletica-1173	111	21	,	,	PUNCT
ecletica-1173	111	22	2002	2002	NUM
ecletica-1173	111	23	)	)	PUNCT
ecletica-1173	111	24	shows	show	VERB
ecletica-1173	111	25	that	that	SCONJ
ecletica-1173	111	26	many	many	ADJ
ecletica-1173	111	27	of	of	ADP
ecletica-1173	111	28	the	the	DET
ecletica-1173	111	29	drugs	drug	NOUN
ecletica-1173	111	30	employed	employ	VERB
ecletica-1173	111	31	for	for	ADP
ecletica-1173	111	32	cancer	cancer	NOUN
ecletica-1173	111	33	treatment	treatment	NOUN
ecletica-1173	111	34	assume	assume	VERB
ecletica-1173	111	35	that	that	SCONJ
ecletica-1173	111	36	the	the	DET
ecletica-1173	111	37	problem	problem	NOUN
ecletica-1173	111	38	is	be	AUX
ecletica-1173	111	39	restricted	restrict	VERB
ecletica-1173	111	40	to	to	ADP
ecletica-1173	111	41	cellular	cellular	ADJ
ecletica-1173	111	42	communication	communication	NOUN
ecletica-1173	111	43	.	.	PUNCT
ecletica-1173	112	1	a	a	DET
ecletica-1173	112	2	methodological	methodological	ADJ
ecletica-1173	112	3	reductionism	reductionism	NOUN
ecletica-1173	112	4	will	will	AUX
ecletica-1173	112	5	be	be	AUX
ecletica-1173	112	6	applied	apply	VERB
ecletica-1173	112	7	to	to	PART
ecletica-1173	112	8	develop	develop	VERB
ecletica-1173	112	9	drugs	drug	NOUN
ecletica-1173	112	10	against	against	ADP
ecletica-1173	112	11	cancer	cancer	NOUN
ecletica-1173	112	12	.	.	PUNCT
ecletica-1173	113	1	many	many	ADJ
ecletica-1173	113	2	of	of	ADP
ecletica-1173	113	3	the	the	DET
ecletica-1173	113	4	drugs	drug	NOUN
ecletica-1173	113	5	are	be	AUX
ecletica-1173	113	6	inhibitors	inhibitor	NOUN
ecletica-1173	113	7	of	of	ADP
ecletica-1173	113	8	the	the	DET
ecletica-1173	113	9	enzyme	enzyme	NOUN
ecletica-1173	113	10	tyrosine	tyrosine	NOUN
ecletica-1173	113	11	kinase	kinase	NOUN
ecletica-1173	113	12	(	(	PUNCT
ecletica-1173	113	13	jemal	jemal	PROPN
ecletica-1173	113	14	et	et	PROPN
ecletica-1173	113	15	al	al	PROPN
ecletica-1173	113	16	.	.	PROPN
ecletica-1173	113	17	,	,	PUNCT
ecletica-1173	113	18	2010	2010	NUM
ecletica-1173	113	19	;	;	PUNCT
ecletica-1173	113	20	shah	shah	PROPN
ecletica-1173	113	21	et	et	PROPN
ecletica-1173	113	22	al	al	PROPN
ecletica-1173	113	23	.	.	PROPN
ecletica-1173	113	24	,	,	PUNCT
ecletica-1173	113	25	2020	2020	NUM
ecletica-1173	113	26	)	)	PUNCT
ecletica-1173	113	27	.	.	PUNCT
ecletica-1173	114	1	the	the	DET
ecletica-1173	114	2	treatment	treatment	NOUN
ecletica-1173	114	3	of	of	ADP
ecletica-1173	114	4	a	a	DET
ecletica-1173	114	5	disease	disease	NOUN
ecletica-1173	114	6	begins	begin	VERB
ecletica-1173	114	7	with	with	ADP
ecletica-1173	114	8	the	the	DET
ecletica-1173	114	9	initial	initial	ADJ
ecletica-1173	114	10	idea	idea	NOUN
ecletica-1173	114	11	that	that	SCONJ
ecletica-1173	114	12	the	the	DET
ecletica-1173	114	13	interaction	interaction	NOUN
ecletica-1173	114	14	of	of	ADP
ecletica-1173	114	15	a	a	DET
ecletica-1173	114	16	molecule	molecule	NOUN
ecletica-1173	114	17	with	with	ADP
ecletica-1173	114	18	an	an	DET
ecletica-1173	114	19	enzyme	enzyme	NOUN
ecletica-1173	114	20	will	will	AUX
ecletica-1173	114	21	give	give	VERB
ecletica-1173	114	22	responses	response	NOUN
ecletica-1173	114	23	for	for	ADP
ecletica-1173	114	24	a	a	DET
ecletica-1173	114	25	multifactorial	multifactorial	ADJ
ecletica-1173	114	26	disease	disease	NOUN
ecletica-1173	114	27	.	.	PUNCT
ecletica-1173	115	1	there	there	PRON
ecletica-1173	115	2	is	be	VERB
ecletica-1173	115	3	a	a	DET
ecletica-1173	115	4	clear	clear	ADJ
ecletica-1173	115	5	limitation	limitation	NOUN
ecletica-1173	115	6	of	of	ADP
ecletica-1173	115	7	the	the	DET
ecletica-1173	115	8	complexity	complexity	NOUN
ecletica-1173	115	9	of	of	ADP
ecletica-1173	115	10	the	the	DET
ecletica-1173	115	11	problem	problem	NOUN
ecletica-1173	115	12	.	.	PUNCT
ecletica-1173	116	1	this	this	DET
ecletica-1173	116	2	limitation	limitation	NOUN
ecletica-1173	116	3	has	have	VERB
ecletica-1173	116	4	an	an	DET
ecletica-1173	116	5	approach	approach	NOUN
ecletica-1173	116	6	based	base	VERB
ecletica-1173	116	7	on	on	ADP
ecletica-1173	116	8	ontological	ontological	ADJ
ecletica-1173	116	9	reductionism	reductionism	NOUN
ecletica-1173	116	10	(	(	PUNCT
ecletica-1173	116	11	when	when	SCONJ
ecletica-1173	116	12	the	the	DET
ecletica-1173	116	13	disease	disease	NOUN
ecletica-1173	116	14	is	be	AUX
ecletica-1173	116	15	based	base	VERB
ecletica-1173	116	16	on	on	ADP
ecletica-1173	116	17	the	the	DET
ecletica-1173	116	18	idea	idea	NOUN
ecletica-1173	116	19	that	that	SCONJ
ecletica-1173	116	20	the	the	DET
ecletica-1173	116	21	constituents	constituent	NOUN
ecletica-1173	116	22	can	can	AUX
ecletica-1173	116	23	explain	explain	VERB
ecletica-1173	116	24	the	the	DET
ecletica-1173	116	25	whole	whole	NOUN
ecletica-1173	116	26	)	)	PUNCT
ecletica-1173	116	27	at	at	ADP
ecletica-1173	116	28	the	the	DET
ecletica-1173	116	29	same	same	ADJ
ecletica-1173	116	30	time	time	NOUN
ecletica-1173	116	31	will	will	AUX
ecletica-1173	116	32	apply	apply	VERB
ecletica-1173	116	33	methodological	methodological	ADJ
ecletica-1173	116	34	reductionism	reductionism	NOUN
ecletica-1173	116	35	to	to	PART
ecletica-1173	116	36	understand	understand	VERB
ecletica-1173	116	37	the	the	DET
ecletica-1173	116	38	disease	disease	NOUN
ecletica-1173	116	39	(	(	PUNCT
ecletica-1173	116	40	due	due	ADP
ecletica-1173	116	41	to	to	ADP
ecletica-1173	116	42	technological	technological	ADJ
ecletica-1173	116	43	limitations	limitation	NOUN
ecletica-1173	116	44	,	,	PUNCT
ecletica-1173	116	45	a	a	DET
ecletica-1173	116	46	simple	simple	ADJ
ecletica-1173	116	47	model	model	NOUN
ecletica-1173	116	48	is	be	AUX
ecletica-1173	116	49	chosen	choose	VERB
ecletica-1173	116	50	to	to	PART
ecletica-1173	116	51	start	start	VERB
ecletica-1173	116	52	the	the	DET
ecletica-1173	116	53	study	study	NOUN
ecletica-1173	116	54	about	about	ADP
ecletica-1173	116	55	the	the	DET
ecletica-1173	116	56	disease	disease	NOUN
ecletica-1173	116	57	)	)	PUNCT
ecletica-1173	116	58	.	.	PUNCT
ecletica-1173	117	1	until	until	ADP
ecletica-1173	117	2	1990	1990	NUM
ecletica-1173	117	3	,	,	PUNCT
ecletica-1173	117	4	mortality	mortality	NOUN
ecletica-1173	117	5	rates	rate	NOUN
ecletica-1173	117	6	had	have	AUX
ecletica-1173	117	7	expanded	expand	VERB
ecletica-1173	117	8	a	a	DET
ecletica-1173	117	9	lot	lot	NOUN
ecletica-1173	117	10	.	.	PUNCT
ecletica-1173	118	1	after	after	ADP
ecletica-1173	118	2	the	the	DET
ecletica-1173	118	3	90s	90	NOUN
ecletica-1173	118	4	,	,	PUNCT
ecletica-1173	118	5	a	a	DET
ecletica-1173	118	6	gradual	gradual	ADJ
ecletica-1173	118	7	decrease	decrease	NOUN
ecletica-1173	118	8	in	in	ADP
ecletica-1173	118	9	the	the	DET
ecletica-1173	118	10	number	number	NOUN
ecletica-1173	118	11	of	of	ADP
ecletica-1173	118	12	cases	case	NOUN
ecletica-1173	118	13	was	be	AUX
ecletica-1173	118	14	observed	observe	VERB
ecletica-1173	118	15	,	,	PUNCT
ecletica-1173	118	16	mainly	mainly	ADV
ecletica-1173	118	17	due	due	ADP
ecletica-1173	118	18	to	to	ADP
ecletica-1173	118	19	cancer	cancer	NOUN
ecletica-1173	118	20	prevention	prevention	NOUN
ecletica-1173	118	21	through	through	ADP
ecletica-1173	118	22	tobacco	tobacco	NOUN
ecletica-1173	118	23	control	control	NOUN
ecletica-1173	118	24	and	and	CCONJ
ecletica-1173	118	25	other	other	ADJ
ecletica-1173	118	26	healthy	healthy	ADJ
ecletica-1173	118	27	behaviors	behavior	NOUN
ecletica-1173	118	28	(	(	PUNCT
ecletica-1173	118	29	chabner	chabner	NOUN
ecletica-1173	118	30	and	and	CCONJ
ecletica-1173	118	31	roberts	roberts	PROPN
ecletica-1173	118	32	junior	junior	PROPN
ecletica-1173	118	33	,	,	PUNCT
ecletica-1173	118	34	2005	2005	NUM
ecletica-1173	118	35	)	)	PUNCT
ecletica-1173	118	36	.	.	PUNCT
ecletica-1173	119	1	however	however	ADV
ecletica-1173	119	2	,	,	PUNCT
ecletica-1173	119	3	patients	patient	NOUN
ecletica-1173	119	4	with	with	ADP
ecletica-1173	119	5	strong	strong	ADJ
ecletica-1173	119	6	tumors	tumor	NOUN
ecletica-1173	119	7	do	do	AUX
ecletica-1173	119	8	not	not	PART
ecletica-1173	119	9	react	react	VERB
ecletica-1173	119	10	to	to	ADP
ecletica-1173	119	11	any	any	DET
ecletica-1173	119	12	drugs	drug	NOUN
ecletica-1173	119	13	(	(	PUNCT
ecletica-1173	119	14	chabner	chabner	NOUN
ecletica-1173	119	15	and	and	CCONJ
ecletica-1173	119	16	roberts	roberts	PROPN
ecletica-1173	119	17	junior	junior	PROPN
ecletica-1173	119	18	,	,	PUNCT
ecletica-1173	119	19	2005	2005	NUM
ecletica-1173	119	20	;	;	PUNCT
ecletica-1173	119	21	ecker	ecker	NOUN
ecletica-1173	119	22	,	,	PUNCT
ecletica-1173	119	23	2015	2015	NUM
ecletica-1173	119	24	)	)	PUNCT
ecletica-1173	119	25	.	.	PUNCT
ecletica-1173	120	1	in	in	ADP
ecletica-1173	120	2	any	any	DET
ecletica-1173	120	3	case	case	NOUN
ecletica-1173	120	4	,	,	PUNCT
ecletica-1173	120	5	the	the	DET
ecletica-1173	120	6	persistence	persistence	NOUN
ecletica-1173	120	7	of	of	ADP
ecletica-1173	120	8	cancer	cancer	NOUN
ecletica-1173	120	9	stem	stem	NOUN
ecletica-1173	120	10	cells	cell	NOUN
ecletica-1173	120	11	and	and	CCONJ
ecletica-1173	120	12	unfavorable	unfavorable	ADJ
ecletica-1173	120	13	medicate	medicate	NOUN
ecletica-1173	120	14	impacts	impact	NOUN
ecletica-1173	120	15	still	still	ADV
ecletica-1173	120	16	restrain	restrain	VERB
ecletica-1173	120	17	their	their	PRON
ecletica-1173	120	18	capacity	capacity	NOUN
ecletica-1173	120	19	to	to	PART
ecletica-1173	120	20	stabilize	stabilize	VERB
ecletica-1173	120	21	or	or	CCONJ
ecletica-1173	120	22	cure	cure	VERB
ecletica-1173	120	23	malignant	malignant	ADJ
ecletica-1173	120	24	invasion	invasion	NOUN
ecletica-1173	120	25	in	in	ADP
ecletica-1173	120	26	the	the	DET
ecletica-1173	120	27	long	long	ADJ
ecletica-1173	120	28	run	run	NOUN
ecletica-1173	120	29	(	(	PUNCT
ecletica-1173	120	30	cardoso	cardoso	NOUN
ecletica-1173	120	31	,	,	PUNCT
ecletica-1173	120	32	2020	2020	NUM
ecletica-1173	120	33	;	;	PUNCT
ecletica-1173	120	34	chabner	chabner	NOUN
ecletica-1173	120	35	and	and	CCONJ
ecletica-1173	120	36	roberts	roberts	PROPN
ecletica-1173	120	37	junior	junior	PROPN
ecletica-1173	120	38	,	,	PUNCT
ecletica-1173	120	39	2005	2005	NUM
ecletica-1173	120	40	;	;	PUNCT
ecletica-1173	120	41	ecker	ecker	NOUN
ecletica-1173	120	42	,	,	PUNCT
ecletica-1173	120	43	2015	2015	NUM
ecletica-1173	120	44	)	)	PUNCT
ecletica-1173	120	45	.	.	PUNCT
ecletica-1173	121	1	the	the	DET
ecletica-1173	121	2	mortality	mortality	NOUN
ecletica-1173	121	3	rates	rate	NOUN
ecletica-1173	121	4	had	have	VERB
ecletica-1173	121	5	a	a	DET
ecletica-1173	121	6	modest	modest	ADJ
ecletica-1173	121	7	decrease	decrease	NOUN
ecletica-1173	121	8	in	in	ADP
ecletica-1173	121	9	recent	recent	ADJ
ecletica-1173	121	10	years	year	NOUN
ecletica-1173	121	11	,	,	PUNCT
ecletica-1173	121	12	but	but	CCONJ
ecletica-1173	121	13	the	the	DET
ecletica-1173	121	14	cancer	cancer	NOUN
ecletica-1173	121	15	remains	remain	VERB
ecletica-1173	121	16	a	a	DET
ecletica-1173	121	17	major	major	ADJ
ecletica-1173	121	18	cause	cause	NOUN
ecletica-1173	121	19	of	of	ADP
ecletica-1173	121	20	death	death	NOUN
ecletica-1173	121	21	within	within	ADP
ecletica-1173	121	22	the	the	DET
ecletica-1173	121	23	industrialized	industrialized	ADJ
ecletica-1173	121	24	world	world	NOUN
ecletica-1173	121	25	.	.	PUNCT
ecletica-1173	122	1	the	the	DET
ecletica-1173	122	2	reasons	reason	NOUN
ecletica-1173	122	3	are	be	AUX
ecletica-1173	122	4	complex	complex	ADJ
ecletica-1173	122	5	:	:	PUNCT
ecletica-1173	122	6	insufficient	insufficient	ADJ
ecletica-1173	122	7	tumor	tumor	NOUN
ecletica-1173	122	8	models	model	NOUN
ecletica-1173	122	9	used	use	VERB
ecletica-1173	122	10	within	within	ADP
ecletica-1173	122	11	the	the	DET
ecletica-1173	122	12	different	different	ADJ
ecletica-1173	122	13	cancer	cancer	NOUN
ecletica-1173	122	14	screening	screen	VERB
ecletica-1173	122	15	programs	program	NOUN
ecletica-1173	122	16	;	;	PUNCT
ecletica-1173	122	17	critical	critical	ADJ
ecletica-1173	122	18	long	long	ADJ
ecletica-1173	122	19	-	-	PUNCT
ecletica-1173	122	20	term	term	NOUN
ecletica-1173	122	21	harmfulness	harmfulness	NOUN
ecletica-1173	122	22	of	of	ADP
ecletica-1173	122	23	anticancer	anticancer	NOUN
ecletica-1173	122	24	drugs	drug	NOUN
ecletica-1173	122	25	;	;	PUNCT
ecletica-1173	122	26	reaction	reaction	NOUN
ecletica-1173	122	27	rates	rate	NOUN
ecletica-1173	122	28	in	in	ADP
ecletica-1173	122	29	patients	patient	NOUN
ecletica-1173	122	30	due	due	ADP
ecletica-1173	122	31	to	to	ADP
ecletica-1173	122	32	sedate	sedate	ADJ
ecletica-1173	122	33	affectability	affectability	NOUN
ecletica-1173	122	34	;	;	PUNCT
ecletica-1173	122	35	rapid	rapid	ADJ
ecletica-1173	122	36	evolution	evolution	NOUN
ecletica-1173	122	37	of	of	ADP
ecletica-1173	122	38	aggressive	aggressive	ADJ
ecletica-1173	122	39	drug	drug	NOUN
ecletica-1173	122	40	resistant	resistant	ADJ
ecletica-1173	122	41	cells	cell	NOUN
ecletica-1173	122	42	due	due	ADJ
ecletica-1173	122	43	to	to	ADP
ecletica-1173	122	44	high	high	ADJ
ecletica-1173	122	45	mutation	mutation	NOUN
ecletica-1173	122	46	rates	rate	NOUN
ecletica-1173	122	47	and	and	CCONJ
ecletica-1173	122	48	selective	selective	ADJ
ecletica-1173	122	49	pressure	pressure	NOUN
ecletica-1173	122	50	,	,	PUNCT
ecletica-1173	122	51	resulting	result	VERB
ecletica-1173	122	52	in	in	ADP
ecletica-1173	122	53	transient	transient	ADJ
ecletica-1173	122	54	treatment	treatment	NOUN
ecletica-1173	122	55	responses	response	NOUN
ecletica-1173	122	56	(	(	PUNCT
ecletica-1173	122	57	johnson	johnson	PROPN
ecletica-1173	122	58	,	,	PUNCT
ecletica-1173	122	59	2013	2013	NUM
ecletica-1173	122	60	;	;	PUNCT
ecletica-1173	122	61	lok	lok	PROPN
ecletica-1173	122	62	,	,	PUNCT
ecletica-1173	122	63	2006	2006	NUM
ecletica-1173	122	64	;	;	PUNCT
ecletica-1173	122	65	ponting	ponting	NOUN
ecletica-1173	122	66	and	and	CCONJ
ecletica-1173	122	67	russell	russell	PROPN
ecletica-1173	122	68	,	,	PUNCT
ecletica-1173	122	69	2002	2002	NUM
ecletica-1173	122	70	;	;	PUNCT
ecletica-1173	122	71	zhong	zhong	PROPN
ecletica-1173	122	72	and	and	CCONJ
ecletica-1173	122	73	virshup	virshup	PROPN
ecletica-1173	122	74	,	,	PUNCT
ecletica-1173	122	75	2020	2020	NUM
ecletica-1173	122	76	)	)	PUNCT
ecletica-1173	122	77	.	.	PUNCT
ecletica-1173	123	1	methodological	methodological	ADJ
ecletica-1173	123	2	reductionism	reductionism	NOUN
ecletica-1173	123	3	approaches	approach	NOUN
ecletica-1173	123	4	to	to	ADP
ecletica-1173	123	5	biomedical	biomedical	ADJ
ecletica-1173	123	6	experiments	experiment	NOUN
ecletica-1173	123	7	have	have	AUX
ecletica-1173	123	8	provided	provide	VERB
ecletica-1173	123	9	significant	significant	ADJ
ecletica-1173	123	10	insight	insight	NOUN
ecletica-1173	123	11	into	into	ADP
ecletica-1173	123	12	the	the	DET
ecletica-1173	123	13	predominant	predominant	ADJ
ecletica-1173	123	14	regions	region	NOUN
ecletica-1173	123	15	associated	associate	VERB
ecletica-1173	123	16	with	with	ADP
ecletica-1173	123	17	specific	specific	ADJ
ecletica-1173	123	18	functions	function	NOUN
ecletica-1173	123	19	.	.	PUNCT
ecletica-1173	124	1	such	such	ADJ
ecletica-1173	124	2	discoveries	discovery	NOUN
ecletica-1173	124	3	,	,	PUNCT
ecletica-1173	124	4	in	in	ADP
ecletica-1173	124	5	turn	turn	NOUN
ecletica-1173	124	6	,	,	PUNCT
ecletica-1173	124	7	led	lead	VERB
ecletica-1173	124	8	to	to	ADP
ecletica-1173	124	9	significant	significant	ADJ
ecletica-1173	124	10	applications	application	NOUN
ecletica-1173	124	11	.	.	PUNCT
ecletica-1173	125	1	for	for	ADP
ecletica-1173	125	2	example	example	NOUN
ecletica-1173	125	3	,	,	PUNCT
ecletica-1173	125	4	antibody	antibody	NOUN
ecletica-1173	125	5	fragments	fragment	NOUN
ecletica-1173	125	6	such	such	ADJ
ecletica-1173	125	7	as	as	ADP
ecletica-1173	125	8	antigen	antigen	ADJ
ecletica-1173	125	9	binding	bind	VERB
ecletica-1173	125	10	fragment	fragment	NOUN
ecletica-1173	125	11	(	(	PUNCT
ecletica-1173	125	12	fab	fab	NOUN
ecletica-1173	125	13	)	)	PUNCT
ecletica-1173	125	14	,	,	PUNCT
ecletica-1173	125	15	single	single	ADJ
ecletica-1173	125	16	chain	chain	NOUN
ecletica-1173	125	17	variable	variable	NOUN
ecletica-1173	125	18	fragment	fragment	NOUN
ecletica-1173	125	19	(	(	PUNCT
ecletica-1173	125	20	scfv	scfv	PROPN
ecletica-1173	125	21	)	)	PUNCT
ecletica-1173	125	22	or	or	CCONJ
ecletica-1173	125	23	fragment	fragment	NOUN
ecletica-1173	125	24	chain	chain	NOUN
ecletica-1173	125	25	(	(	PUNCT
ecletica-1173	125	26	fc	fc	INTJ
ecletica-1173	125	27	)	)	PUNCT
ecletica-1173	125	28	are	be	AUX
ecletica-1173	125	29	widely	widely	ADV
ecletica-1173	125	30	used	use	VERB
ecletica-1173	125	31	as	as	ADP
ecletica-1173	125	32	screening	screen	VERB
ecletica-1173	125	33	reagents	reagent	NOUN
ecletica-1173	125	34	and	and	CCONJ
ecletica-1173	125	35	as	as	ADP
ecletica-1173	125	36	therapeutic	therapeutic	ADJ
ecletica-1173	125	37	potentials	potential	NOUN
ecletica-1173	125	38	(	(	PUNCT
ecletica-1173	125	39	ahn	ahn	PROPN
ecletica-1173	125	40	et	et	PROPN
ecletica-1173	125	41	al	al	PROPN
ecletica-1173	125	42	.	.	PROPN
ecletica-1173	125	43	,	,	PUNCT
ecletica-1173	125	44	2006	2006	NUM
ecletica-1173	125	45	;	;	PUNCT
ecletica-1173	125	46	van	van	NOUN
ecletica-1173	125	47	regenmortel	regenmortel	NOUN
ecletica-1173	125	48	,	,	PUNCT
ecletica-1173	125	49	2004	2004	NUM
ecletica-1173	125	50	)	)	PUNCT
ecletica-1173	125	51	.	.	PUNCT
ecletica-1173	126	1	structural	structural	ADJ
ecletica-1173	126	2	refinement	refinement	NOUN
ecletica-1173	126	3	protein	protein	NOUN
ecletica-1173	126	4	domain	domain	NOUN
ecletica-1173	126	5	classifications	classification	NOUN
ecletica-1173	126	6	and	and	CCONJ
ecletica-1173	126	7	functional	functional	ADJ
ecletica-1173	126	8	predictions	prediction	NOUN
ecletica-1173	126	9	are	be	AUX
ecletica-1173	126	10	additionally	additionally	ADV
ecletica-1173	126	11	used	use	VERB
ecletica-1173	126	12	for	for	ADP
ecletica-1173	126	13	therapeutic	therapeutic	ADJ
ecletica-1173	126	14	purposes	purpose	NOUN
ecletica-1173	126	15	(	(	PUNCT
ecletica-1173	126	16	krakauer	krakauer	PROPN
ecletica-1173	126	17	et	et	PROPN
ecletica-1173	126	18	al	al	PROPN
ecletica-1173	126	19	.	.	PROPN
ecletica-1173	126	20	,	,	PUNCT
ecletica-1173	126	21	2017	2017	NUM
ecletica-1173	126	22	)	)	PUNCT
ecletica-1173	126	23	.	.	PUNCT
ecletica-1173	127	1	however	however	ADV
ecletica-1173	127	2	,	,	PUNCT
ecletica-1173	127	3	the	the	DET
ecletica-1173	127	4	reductionist	reductionist	ADJ
ecletica-1173	127	5	approach	approach	NOUN
ecletica-1173	127	6	,	,	PUNCT
ecletica-1173	127	7	while	while	SCONJ
ecletica-1173	127	8	accessible	accessible	ADJ
ecletica-1173	127	9	and	and	CCONJ
ecletica-1173	127	10	incredibly	incredibly	ADV
ecletica-1173	127	11	useful	useful	ADJ
ecletica-1173	127	12	,	,	PUNCT
ecletica-1173	127	13	ignores	ignore	VERB
ecletica-1173	127	14	the	the	DET
ecletica-1173	127	15	broader	broad	ADJ
ecletica-1173	127	16	framework	framework	NOUN
ecletica-1173	127	17	of	of	ADP
ecletica-1173	127	18	interregional	interregional	ADJ
ecletica-1173	127	19	communications	communication	NOUN
ecletica-1173	127	20	and	and	CCONJ
ecletica-1173	127	21	their	their	PRON
ecletica-1173	127	22	possible	possible	ADJ
ecletica-1173	127	23	cooperative	cooperative	ADJ
ecletica-1173	127	24	effects	effect	NOUN
ecletica-1173	127	25	(	(	PUNCT
ecletica-1173	127	26	krakauer	krakauer	PROPN
ecletica-1173	127	27	et	et	PROPN
ecletica-1173	127	28	al	al	PROPN
ecletica-1173	127	29	.	.	PROPN
ecletica-1173	127	30	,	,	PUNCT
ecletica-1173	127	31	2017	2017	NUM
ecletica-1173	127	32	)	)	PUNCT
ecletica-1173	127	33	that	that	PRON
ecletica-1173	127	34	would	would	AUX
ecletica-1173	127	35	be	be	AUX
ecletica-1173	127	36	useful	useful	ADJ
ecletica-1173	127	37	for	for	ADP
ecletica-1173	127	38	further	further	ADJ
ecletica-1173	127	39	analysis	analysis	NOUN
ecletica-1173	127	40	.	.	PUNCT
ecletica-1173	128	1	given	give	VERB
ecletica-1173	128	2	the	the	DET
ecletica-1173	128	3	advances	advance	NOUN
ecletica-1173	128	4	in	in	ADP
ecletica-1173	128	5	technology	technology	NOUN
ecletica-1173	128	6	that	that	PRON
ecletica-1173	128	7	have	have	AUX
ecletica-1173	128	8	led	lead	VERB
ecletica-1173	128	9	to	to	ADP
ecletica-1173	128	10	advanced	advanced	ADJ
ecletica-1173	128	11	experimental	experimental	ADJ
ecletica-1173	128	12	and	and	CCONJ
ecletica-1173	128	13	computational	computational	ADJ
ecletica-1173	128	14	techniques	technique	NOUN
ecletica-1173	128	15	in	in	ADP
ecletica-1173	128	16	recent	recent	ADJ
ecletica-1173	128	17	years	year	NOUN
ecletica-1173	128	18	,	,	PUNCT
ecletica-1173	128	19	the	the	DET
ecletica-1173	128	20	subsequent	subsequent	ADJ
ecletica-1173	128	21	level	level	NOUN
ecletica-1173	128	22	of	of	ADP
ecletica-1173	128	23	scientific	scientific	ADJ
ecletica-1173	128	24	advances	advance	NOUN
ecletica-1173	128	25	may	may	AUX
ecletica-1173	128	26	require	require	VERB
ecletica-1173	128	27	proteins	protein	NOUN
ecletica-1173	128	28	to	to	PART
ecletica-1173	128	29	be	be	AUX
ecletica-1173	128	30	analyzed	analyze	VERB
ecletica-1173	128	31	in	in	ADP
ecletica-1173	128	32	the	the	DET
ecletica-1173	128	33	most	most	ADV
ecletica-1173	128	34	holistic	holistic	ADJ
ecletica-1173	128	35	way	way	NOUN
ecletica-1173	128	36	.	.	PUNCT
ecletica-1173	129	1	these	these	DET
ecletica-1173	129	2	approaches	approach	NOUN
ecletica-1173	129	3	are	be	AUX
ecletica-1173	129	4	already	already	ADV
ecletica-1173	129	5	present	present	ADJ
ecletica-1173	129	6	in	in	ADP
ecletica-1173	129	7	various	various	ADJ
ecletica-1173	129	8	specialties	specialty	NOUN
ecletica-1173	129	9	with	with	ADP
ecletica-1173	129	10	these	these	DET
ecletica-1173	129	11	efforts	effort	NOUN
ecletica-1173	129	12	to	to	PART
ecletica-1173	129	13	jointly	jointly	ADV
ecletica-1173	129	14	generate	generate	VERB
ecletica-1173	129	15	ideas	idea	NOUN
ecletica-1173	129	16	derived	derive	VERB
ecletica-1173	129	17	from	from	ADP
ecletica-1173	129	18	reductionist	reductionist	ADJ
ecletica-1173	129	19	investigation	investigation	NOUN
ecletica-1173	129	20	(	(	PUNCT
ecletica-1173	129	21	albergante	albergante	PROPN
ecletica-1173	129	22	et	et	PROPN
ecletica-1173	129	23	al	al	PROPN
ecletica-1173	129	24	.	.	PROPN
ecletica-1173	129	25	,	,	PUNCT
ecletica-1173	129	26	2016	2016	NUM
ecletica-1173	129	27	;	;	PUNCT
ecletica-1173	129	28	bieber	bieber	PROPN
ecletica-1173	129	29	,	,	PUNCT
ecletica-1173	129	30	2015	2015	NUM
ecletica-1173	129	31	;	;	PUNCT
ecletica-1173	129	32	fardet	fardet	NOUN
ecletica-1173	129	33	,	,	PUNCT
ecletica-1173	129	34	2014	2014	NUM
ecletica-1173	129	35	;	;	PUNCT
ecletica-1173	130	1	phua	phua	PROPN
ecletica-1173	130	2	et	et	PROPN
ecletica-1173	130	3	al	al	PROPN
ecletica-1173	130	4	.	.	PROPN
ecletica-1173	130	5	,	,	PUNCT
ecletica-1173	130	6	2019	2019	NUM
ecletica-1173	130	7	)	)	PUNCT
ecletica-1173	130	8	.	.	PUNCT
ecletica-1173	131	1	according	accord	VERB
ecletica-1173	131	2	to	to	ADP
ecletica-1173	131	3	van	van	PROPN
ecletica-1173	131	4	regenmortel	regenmortel	NOUN
ecletica-1173	131	5	(	(	PUNCT
ecletica-1173	131	6	2004	2004	NUM
ecletica-1173	131	7	)	)	PUNCT
ecletica-1173	131	8	,	,	PUNCT
ecletica-1173	131	9	it	it	PRON
ecletica-1173	131	10	is	be	AUX
ecletica-1173	131	11	important	important	ADJ
ecletica-1173	131	12	to	to	PART
ecletica-1173	131	13	revisit	revisit	VERB
ecletica-1173	131	14	biological	biological	ADJ
ecletica-1173	131	15	systems	system	NOUN
ecletica-1173	131	16	completely	completely	ADV
ecletica-1173	131	17	as	as	ADP
ecletica-1173	131	18	a	a	DET
ecletica-1173	131	19	whole	whole	NOUN
ecletica-1173	131	20	(	(	PUNCT
ecletica-1173	131	21	o’sullivan	o’sullivan	NOUN
ecletica-1173	131	22	et	et	NOUN
ecletica-1173	131	23	al	al	PROPN
ecletica-1173	131	24	.	.	PROPN
ecletica-1173	131	25	,	,	PUNCT
ecletica-1173	131	26	2018	2018	NUM
ecletica-1173	131	27	;	;	PUNCT
ecletica-1173	131	28	soto	soto	NOUN
ecletica-1173	131	29	and	and	CCONJ
ecletica-1173	131	30	sonnenschein	sonnenschein	ADJ
ecletica-1173	131	31	,	,	PUNCT
ecletica-1173	131	32	2005	2005	NUM
ecletica-1173	131	33	)	)	PUNCT
ecletica-1173	131	34	.	.	PUNCT
ecletica-1173	132	1	in	in	ADP
ecletica-1173	132	2	this	this	DET
ecletica-1173	132	3	line	line	NOUN
ecletica-1173	132	4	of	of	ADP
ecletica-1173	132	5	thinking	thinking	NOUN
ecletica-1173	132	6	,	,	PUNCT
ecletica-1173	132	7	while	while	SCONJ
ecletica-1173	132	8	limitations	limitation	NOUN
ecletica-1173	132	9	on	on	ADP
ecletica-1173	132	10	looking	look	VERB
ecletica-1173	132	11	at	at	ADP
ecletica-1173	132	12	whole	whole	ADJ
ecletica-1173	132	13	systems	system	NOUN
ecletica-1173	132	14	are	be	AUX
ecletica-1173	132	15	always	always	ADV
ecletica-1173	132	16	present	present	ADJ
ecletica-1173	132	17	,	,	PUNCT
ecletica-1173	132	18	it	it	PRON
ecletica-1173	132	19	is	be	AUX
ecletica-1173	132	20	possible	possible	ADJ
ecletica-1173	132	21	,	,	PUNCT
ecletica-1173	132	22	however	however	ADV
ecletica-1173	132	23	,	,	PUNCT
ecletica-1173	132	24	to	to	PART
ecletica-1173	132	25	already	already	ADV
ecletica-1173	132	26	be	be	AUX
ecletica-1173	132	27	reaching	reach	VERB
ecletica-1173	132	28	a	a	DET
ecletica-1173	132	29	saturation	saturation	NOUN
ecletica-1173	132	30	point	point	NOUN
ecletica-1173	132	31	for	for	ADP
ecletica-1173	132	32	scientific	scientific	ADJ
ecletica-1173	132	33	advances	advance	NOUN
ecletica-1173	132	34	within	within	ADP
ecletica-1173	132	35	the	the	DET
ecletica-1173	132	36	reductionist	reductionist	ADJ
ecletica-1173	132	37	approach	approach	NOUN
ecletica-1173	132	38	.	.	PUNCT
ecletica-1173	133	1	recent	recent	ADJ
ecletica-1173	133	2	literature	literature	NOUN
ecletica-1173	133	3	has	have	AUX
ecletica-1173	133	4	suggested	suggest	VERB
ecletica-1173	133	5	an	an	DET
ecletica-1173	133	6	analysis	analysis	NOUN
ecletica-1173	133	7	of	of	ADP
ecletica-1173	133	8	proteins	protein	NOUN
ecletica-1173	133	9	in	in	ADP
ecletica-1173	133	10	their	their	PRON
ecletica-1173	133	11	entirety	entirety	NOUN
ecletica-1173	133	12	(	(	PUNCT
ecletica-1173	133	13	when	when	SCONJ
ecletica-1173	133	14	possible	possible	ADJ
ecletica-1173	133	15	)	)	PUNCT
ecletica-1173	133	16	(	(	PUNCT
ecletica-1173	133	17	van	van	PROPN
ecletica-1173	133	18	ommen	omman	NOUN
ecletica-1173	133	19	et	et	PROPN
ecletica-1173	133	20	al	al	PROPN
ecletica-1173	133	21	.	.	PROPN
ecletica-1173	133	22	,	,	PUNCT
ecletica-1173	133	23	2008	2008	NUM
ecletica-1173	133	24	)	)	PUNCT
ecletica-1173	133	25	.	.	PUNCT
ecletica-1173	134	1	the	the	DET
ecletica-1173	134	2	reductionist	reductionist	ADJ
ecletica-1173	134	3	nutritional	nutritional	ADJ
ecletica-1173	134	4	approach	approach	NOUN
ecletica-1173	134	5	thrived	thrive	VERB
ecletica-1173	134	6	using	use	VERB
ecletica-1173	134	7	the	the	DET
ecletica-1173	134	8	tools	tool	NOUN
ecletica-1173	134	9	of	of	ADP
ecletica-1173	134	10	analytical	analytical	ADJ
ecletica-1173	134	11	chemistry	chemistry	NOUN
ecletica-1173	134	12	and	and	CCONJ
ecletica-1173	134	13	experimental	experimental	ADJ
ecletica-1173	134	14	biology	biology	NOUN
ecletica-1173	134	15	in	in	ADP
ecletica-1173	134	16	nutrition	nutrition	NOUN
ecletica-1173	134	17	.	.	PUNCT
ecletica-1173	135	1	recent	recent	ADJ
ecletica-1173	135	2	advances	advance	NOUN
ecletica-1173	135	3	in	in	ADP
ecletica-1173	135	4	high	high	ADJ
ecletica-1173	135	5	-	-	PUNCT
ecletica-1173	135	6	yield	yield	NOUN
ecletica-1173	135	7	organic	organic	ADJ
ecletica-1173	135	8	molecules	molecule	NOUN
ecletica-1173	135	9	complex	complex	ADJ
ecletica-1173	135	10	structure	structure	NOUN
ecletica-1173	135	11	(	(	PUNCT
ecletica-1173	135	12	omic	omic	ADJ
ecletica-1173	135	13	)	)	PUNCT
ecletica-1173	135	14	technology	technology	NOUN
ecletica-1173	135	15	,	,	PUNCT
ecletica-1173	135	16	computational	computational	ADJ
ecletica-1173	135	17	and	and	CCONJ
ecletica-1173	135	18	statistical	statistical	ADJ
ecletica-1173	135	19	tools	tool	NOUN
ecletica-1173	135	20	have	have	AUX
ecletica-1173	135	21	led	lead	VERB
ecletica-1173	135	22	scientists	scientist	NOUN
ecletica-1173	135	23	to	to	PART
ecletica-1173	135	24	explore	explore	VERB
ecletica-1173	135	25	current	current	ADJ
ecletica-1173	135	26	challenges	challenge	NOUN
ecletica-1173	135	27	.	.	PUNCT
ecletica-1173	136	1	these	these	DET
ecletica-1173	136	2	tools	tool	NOUN
ecletica-1173	136	3	provide	provide	VERB
ecletica-1173	136	4	global	global	ADJ
ecletica-1173	136	5	measurements	measurement	NOUN
ecletica-1173	136	6	reporting	report	VERB
ecletica-1173	136	7	the	the	DET
ecletica-1173	136	8	diversity	diversity	NOUN
ecletica-1173	136	9	of	of	ADP
ecletica-1173	136	10	individuals	individual	NOUN
ecletica-1173	136	11	and	and	CCONJ
ecletica-1173	136	12	complex	complex	ADJ
ecletica-1173	136	13	interactions	interaction	NOUN
ecletica-1173	136	14	between	between	ADP
ecletica-1173	136	15	vitamins	vitamin	NOUN
ecletica-1173	136	16	and	and	CCONJ
ecletica-1173	136	17	human	human	ADJ
ecletica-1173	136	18	bodies	body	NOUN
ecletica-1173	136	19	(	(	PUNCT
ecletica-1173	136	20	davis	davis	PROPN
ecletica-1173	136	21	and	and	CCONJ
ecletica-1173	136	22	hord	hord	PROPN
ecletica-1173	136	23	,	,	PUNCT
ecletica-1173	136	24	2005	2005	NUM
ecletica-1173	136	25	;	;	PUNCT
ecletica-1173	136	26	omenn	omenn	PROPN
ecletica-1173	136	27	et	et	PROPN
ecletica-1173	136	28	al	al	PROPN
ecletica-1173	136	29	.	.	PROPN
ecletica-1173	136	30	,	,	PUNCT
ecletica-1173	136	31	1996	1996	NUM
ecletica-1173	136	32	;	;	PUNCT
ecletica-1173	136	33	weinstock	weinstock	NOUN
ecletica-1173	136	34	,	,	PUNCT
ecletica-1173	136	35	2012	2012	NUM
ecletica-1173	136	36	)	)	PUNCT
ecletica-1173	136	37	.	.	PUNCT
ecletica-1173	137	1	high	high	ADJ
ecletica-1173	137	2	-	-	PUNCT
ecletica-1173	137	3	performance	performance	NOUN
ecletica-1173	137	4	omics	omic	NOUN
ecletica-1173	137	5	technology	technology	NOUN
ecletica-1173	137	6	includes	include	VERB
ecletica-1173	137	7	genomics	genomic	NOUN
ecletica-1173	137	8	,	,	PUNCT
ecletica-1173	137	9	transcriptomics	transcriptomic	NOUN
ecletica-1173	137	10	,	,	PUNCT
ecletica-1173	137	11	proteomics	proteomic	NOUN
ecletica-1173	137	12	,	,	PUNCT
ecletica-1173	137	13	metabolomics	metabolomic	NOUN
ecletica-1173	137	14	and	and	CCONJ
ecletica-1173	137	15	metagenomics	metagenomic	NOUN
ecletica-1173	137	16	.	.	PUNCT
ecletica-1173	138	1	nutrigenomics	nutrigenomics	PROPN
ecletica-1173	138	2	,	,	PUNCT
ecletica-1173	138	3	or	or	CCONJ
ecletica-1173	138	4	genomics	genomic	NOUN
ecletica-1173	138	5	in	in	ADP
ecletica-1173	138	6	nutrition	nutrition	NOUN
ecletica-1173	138	7	,	,	PUNCT
ecletica-1173	138	8	refer	refer	VERB
ecletica-1173	138	9	to	to	ADP
ecletica-1173	138	10	the	the	DET
ecletica-1173	138	11	study	study	NOUN
ecletica-1173	138	12	of	of	ADP
ecletica-1173	138	13	how	how	SCONJ
ecletica-1173	138	14	genes	gene	NOUN
ecletica-1173	138	15	and	and	CCONJ
ecletica-1173	138	16	dietary	dietary	ADJ
ecletica-1173	138	17	components	component	NOUN
ecletica-1173	138	18	interact	interact	VERB
ecletica-1173	138	19	to	to	ADP
ecletica-1173	138	20	http://revista.iq.unesp.br/ojs/index.php/ecletica/index	http://revista.iq.unesp.br/ojs/index.php/ecletica/index	NOUN
ecletica-1173	138	21	https://doi.org/10.26850/1678-4618eqj.v46.3.2021.p17-32	https://doi.org/10.26850/1678-4618eqj.v46.3.2021.p17-32	PROPN
ecletica-1173	138	22	review	review	NOUN
ecletica-1173	138	23	article	article	NOUN
ecletica-1173	138	24	iq.unesp.br/ecletica	iq.unesp.br/ecletica	PROPN
ecletica-1173	138	25	21	21	NUM
ecletica-1173	138	26	eclética	eclética	PROPN
ecletica-1173	138	27	química	química	PROPN
ecletica-1173	138	28	journal	journal	PROPN
ecletica-1173	138	29	,	,	PUNCT
ecletica-1173	138	30	vol	vol	NOUN
ecletica-1173	138	31	.	.	PROPN
ecletica-1173	138	32	46	46	NUM
ecletica-1173	138	33	,	,	PUNCT
ecletica-1173	138	34	n.	n.	NOUN
ecletica-1173	138	35	3	3	NUM
ecletica-1173	138	36	,	,	PUNCT
ecletica-1173	138	37	2021	2021	NUM
ecletica-1173	138	38	,	,	PUNCT
ecletica-1173	138	39	17	17	NUM
ecletica-1173	138	40	-	-	SYM
ecletica-1173	138	41	32	32	NUM
ecletica-1173	138	42	issn	issn	NOUN
ecletica-1173	138	43	:	:	PUNCT
ecletica-1173	138	44	1678	1678	NUM
ecletica-1173	138	45	-	-	SYM
ecletica-1173	138	46	4618	4618	NUM
ecletica-1173	138	47	doi	doi	NOUN
ecletica-1173	138	48	:	:	PUNCT
ecletica-1173	138	49	10.26850/1678	10.26850/1678	NUM
ecletica-1173	138	50	-	-	SYM
ecletica-1173	138	51	4618eqj.v46.3.2021.p17	4618eqj.v46.3.2021.p17	NOUN
ecletica-1173	138	52	-	-	SYM
ecletica-1173	138	53	32	32	NUM
ecletica-1173	138	54	change	change	NOUN
ecletica-1173	138	55	the	the	DET
ecletica-1173	138	56	phenotype	phenotype	NOUN
ecletica-1173	138	57	(	(	PUNCT
ecletica-1173	138	58	blumberg	blumberg	PROPN
ecletica-1173	138	59	,	,	PUNCT
ecletica-1173	138	60	1994	1994	NUM
ecletica-1173	138	61	;	;	PUNCT
ecletica-1173	138	62	chiritaemandi	chiritaemandi	NOUN
ecletica-1173	138	63	and	and	CCONJ
ecletica-1173	138	64	niculescu	niculescu	NOUN
ecletica-1173	138	65	,	,	PUNCT
ecletica-1173	138	66	2020	2020	NUM
ecletica-1173	138	67	)	)	PUNCT
ecletica-1173	138	68	.	.	PUNCT
ecletica-1173	139	1	the	the	DET
ecletica-1173	139	2	three	three	NUM
ecletica-1173	139	3	genomic	genomic	ADJ
ecletica-1173	139	4	categories	category	NOUN
ecletica-1173	139	5	in	in	ADP
ecletica-1173	139	6	which	which	PRON
ecletica-1173	139	7	knowledge	knowledge	NOUN
ecletica-1173	139	8	is	be	AUX
ecletica-1173	139	9	critically	critically	ADV
ecletica-1173	139	10	necessary	necessary	ADJ
ecletica-1173	139	11	are	be	AUX
ecletica-1173	139	12	human	human	ADJ
ecletica-1173	139	13	genomics	genomic	NOUN
ecletica-1173	139	14	,	,	PUNCT
ecletica-1173	139	15	plant	plant	NOUN
ecletica-1173	139	16	and	and	CCONJ
ecletica-1173	139	17	animal	animal	NOUN
ecletica-1173	139	18	genomics	genomic	NOUN
ecletica-1173	139	19	,	,	PUNCT
ecletica-1173	139	20	and	and	CCONJ
ecletica-1173	139	21	microbial	microbial	ADJ
ecletica-1173	139	22	genomics	genomic	NOUN
ecletica-1173	139	23	(	(	PUNCT
ecletica-1173	139	24	davis	davis	PROPN
ecletica-1173	139	25	and	and	CCONJ
ecletica-1173	139	26	hord	hord	PROPN
ecletica-1173	139	27	,	,	PUNCT
ecletica-1173	139	28	2005	2005	NUM
ecletica-1173	139	29	)	)	PUNCT
ecletica-1173	139	30	.	.	PUNCT
ecletica-1173	140	1	nutrigenomics	nutrigenomics	PROPN
ecletica-1173	140	2	explain	explain	VERB
ecletica-1173	140	3	how	how	SCONJ
ecletica-1173	140	4	the	the	DET
ecletica-1173	140	5	response	response	NOUN
ecletica-1173	140	6	to	to	ADP
ecletica-1173	140	7	food	food	NOUN
ecletica-1173	140	8	components	component	NOUN
ecletica-1173	140	9	depends	depend	VERB
ecletica-1173	140	10	on	on	ADP
ecletica-1173	140	11	an	an	DET
ecletica-1173	140	12	individual	individual	NOUN
ecletica-1173	140	13	’s	’s	PART
ecletica-1173	140	14	genetic	genetic	ADJ
ecletica-1173	140	15	background	background	NOUN
ecletica-1173	140	16	(	(	PUNCT
ecletica-1173	140	17	nutrigenetics	nutrigenetic	NOUN
ecletica-1173	140	18	)	)	PUNCT
ecletica-1173	140	19	,	,	PUNCT
ecletica-1173	140	20	nutrient	nutrient	NOUN
ecletica-1173	140	21	-	-	PUNCT
ecletica-1173	140	22	induced	induce	VERB
ecletica-1173	140	23	changes	change	NOUN
ecletica-1173	140	24	in	in	ADP
ecletica-1173	140	25	dna	dna	PROPN
ecletica-1173	140	26	methylation	methylation	NOUN
ecletica-1173	140	27	,	,	PUNCT
ecletica-1173	140	28	chromatin	chromatin	NOUN
ecletica-1173	140	29	changes	change	NOUN
ecletica-1173	140	30	(	(	PUNCT
ecletica-1173	140	31	nutritional	nutritional	ADJ
ecletica-1173	140	32	epigenetics	epigenetic	NOUN
ecletica-1173	140	33	)	)	PUNCT
ecletica-1173	140	34	,	,	PUNCT
ecletica-1173	140	35	nutrient	nutrient	NOUN
ecletica-1173	140	36	-	-	PUNCT
ecletica-1173	140	37	induced	induce	VERB
ecletica-1173	140	38	changes	change	NOUN
ecletica-1173	140	39	in	in	ADP
ecletica-1173	140	40	gene	gene	NOUN
ecletica-1173	140	41	expression	expression	NOUN
ecletica-1173	140	42	(	(	PUNCT
ecletica-1173	140	43	nutritional	nutritional	ADJ
ecletica-1173	140	44	transcriptomics	transcriptomic	NOUN
ecletica-1173	140	45	)	)	PUNCT
ecletica-1173	140	46	and	and	CCONJ
ecletica-1173	140	47	proteins	protein	NOUN
ecletica-1173	140	48	(	(	PUNCT
ecletica-1173	140	49	nutritional	nutritional	ADJ
ecletica-1173	140	50	proteomics	proteomic	NOUN
ecletica-1173	140	51	)	)	PUNCT
ecletica-1173	140	52	(	(	PUNCT
ecletica-1173	140	53	blumberg	blumberg	PROPN
ecletica-1173	140	54	,	,	PUNCT
ecletica-1173	140	55	1994	1994	NUM
ecletica-1173	140	56	)	)	PUNCT
ecletica-1173	140	57	.	.	PUNCT
ecletica-1173	141	1	metabolomics	metabolomic	NOUN
ecletica-1173	141	2	is	be	AUX
ecletica-1173	141	3	one	one	NUM
ecletica-1173	141	4	of	of	ADP
ecletica-1173	141	5	the	the	DET
ecletica-1173	141	6	newest	new	ADJ
ecletica-1173	141	7	omics	omic	NOUN
ecletica-1173	141	8	and	and	CCONJ
ecletica-1173	141	9	has	have	AUX
ecletica-1173	141	10	been	be	AUX
ecletica-1173	141	11	defined	define	VERB
ecletica-1173	141	12	as	as	ADP
ecletica-1173	141	13	a	a	DET
ecletica-1173	141	14	comprehensive	comprehensive	ADJ
ecletica-1173	141	15	analysis	analysis	NOUN
ecletica-1173	141	16	of	of	ADP
ecletica-1173	141	17	changes	change	NOUN
ecletica-1173	141	18	in	in	ADP
ecletica-1173	141	19	many	many	ADJ
ecletica-1173	141	20	low	low	ADJ
ecletica-1173	141	21	molecular	molecular	ADJ
ecletica-1173	141	22	weight	weight	NOUN
ecletica-1173	141	23	compounds	compound	NOUN
ecletica-1173	141	24	and	and	CCONJ
ecletica-1173	141	25	their	their	PRON
ecletica-1173	141	26	fluxes	flux	NOUN
ecletica-1173	141	27	through	through	ADP
ecletica-1173	141	28	human	human	ADJ
ecletica-1173	141	29	metabolism	metabolism	NOUN
ecletica-1173	141	30	in	in	ADP
ecletica-1173	141	31	response	response	NOUN
ecletica-1173	141	32	to	to	ADP
ecletica-1173	141	33	dietary	dietary	ADJ
ecletica-1173	141	34	treatments	treatment	NOUN
ecletica-1173	141	35	(	(	PUNCT
ecletica-1173	141	36	davis	davis	PROPN
ecletica-1173	141	37	and	and	CCONJ
ecletica-1173	141	38	hord	hord	PROPN
ecletica-1173	141	39	,	,	PUNCT
ecletica-1173	141	40	2005	2005	NUM
ecletica-1173	141	41	)	)	PUNCT
ecletica-1173	141	42	.	.	PUNCT
ecletica-1173	142	1	metagenomics	metagenomic	NOUN
ecletica-1173	142	2	studies	study	VERB
ecletica-1173	142	3	the	the	DET
ecletica-1173	142	4	combined	combine	VERB
ecletica-1173	142	5	genome	genome	NOUN
ecletica-1173	142	6	of	of	ADP
ecletica-1173	142	7	microbial	microbial	ADJ
ecletica-1173	142	8	communities	community	NOUN
ecletica-1173	142	9	using	use	VERB
ecletica-1173	142	10	next	next	ADJ
ecletica-1173	142	11	generation	generation	NOUN
ecletica-1173	142	12	of	of	ADP
ecletica-1173	142	13	dna	dna	NOUN
ecletica-1173	142	14	sequencing	sequencing	NOUN
ecletica-1173	142	15	,	,	PUNCT
ecletica-1173	142	16	which	which	PRON
ecletica-1173	142	17	explains	explain	VERB
ecletica-1173	142	18	differences	difference	NOUN
ecletica-1173	142	19	in	in	ADP
ecletica-1173	142	20	community	community	NOUN
ecletica-1173	142	21	structure	structure	NOUN
ecletica-1173	142	22	between	between	ADP
ecletica-1173	142	23	sampling	sample	VERB
ecletica-1173	142	24	sites	site	NOUN
ecletica-1173	142	25	,	,	PUNCT
ecletica-1173	142	26	individuals	individual	NOUN
ecletica-1173	142	27	,	,	PUNCT
ecletica-1173	142	28	and	and	CCONJ
ecletica-1173	142	29	between	between	ADP
ecletica-1173	142	30	healthy	healthy	ADJ
ecletica-1173	142	31	versus	versus	ADP
ecletica-1173	142	32	disease	disease	NOUN
ecletica-1173	142	33	states	state	NOUN
ecletica-1173	142	34	(	(	PUNCT
ecletica-1173	142	35	rietjens	rietjen	NOUN
ecletica-1173	142	36	et	et	PROPN
ecletica-1173	142	37	al	al	PROPN
ecletica-1173	142	38	.	.	PROPN
ecletica-1173	142	39	,	,	PUNCT
ecletica-1173	142	40	2002	2002	NUM
ecletica-1173	142	41	)	)	PUNCT
ecletica-1173	142	42	.	.	PUNCT
ecletica-1173	143	1	a	a	DET
ecletica-1173	143	2	good	good	ADJ
ecletica-1173	143	3	example	example	NOUN
ecletica-1173	143	4	of	of	ADP
ecletica-1173	143	5	limitation	limitation	NOUN
ecletica-1173	143	6	related	relate	VERB
ecletica-1173	143	7	to	to	ADP
ecletica-1173	143	8	the	the	DET
ecletica-1173	143	9	application	application	NOUN
ecletica-1173	143	10	of	of	ADP
ecletica-1173	143	11	reductionism	reductionism	NOUN
ecletica-1173	143	12	in	in	ADP
ecletica-1173	143	13	nutritional	nutritional	ADJ
ecletica-1173	143	14	research	research	NOUN
ecletica-1173	143	15	can	can	AUX
ecletica-1173	143	16	be	be	AUX
ecletica-1173	143	17	found	find	VERB
ecletica-1173	143	18	in	in	ADP
ecletica-1173	143	19	prospective	prospective	ADJ
ecletica-1173	143	20	studies	study	NOUN
ecletica-1173	143	21	that	that	PRON
ecletica-1173	143	22	investigate	investigate	VERB
ecletica-1173	143	23	the	the	DET
ecletica-1173	143	24	effects	effect	NOUN
ecletica-1173	143	25	of	of	ADP
ecletica-1173	143	26	the	the	DET
ecletica-1173	143	27	intake	intake	NOUN
ecletica-1173	143	28	of	of	ADP
ecletica-1173	143	29	isolated	isolated	ADJ
ecletica-1173	143	30	antioxidant	antioxidant	ADJ
ecletica-1173	143	31	vitamin	vitamin	NOUN
ecletica-1173	143	32	intake	intake	NOUN
ecletica-1173	143	33	and	and	CCONJ
ecletica-1173	143	34	cancer	cancer	NOUN
ecletica-1173	143	35	development	development	NOUN
ecletica-1173	143	36	(	(	PUNCT
ecletica-1173	143	37	fardet	fardet	NOUN
ecletica-1173	143	38	and	and	CCONJ
ecletica-1173	143	39	rock	rock	NOUN
ecletica-1173	143	40	,	,	PUNCT
ecletica-1173	143	41	2014	2014	NUM
ecletica-1173	143	42	;	;	PUNCT
ecletica-1173	143	43	peterson	peterson	NOUN
ecletica-1173	143	44	,	,	PUNCT
ecletica-1173	143	45	2008	2008	NUM
ecletica-1173	143	46	)	)	PUNCT
ecletica-1173	143	47	.	.	PUNCT
ecletica-1173	144	1	the	the	DET
ecletica-1173	144	2	results	result	NOUN
ecletica-1173	144	3	showed	show	VERB
ecletica-1173	144	4	controversies	controversy	NOUN
ecletica-1173	144	5	.	.	PUNCT
ecletica-1173	145	1	although	although	SCONJ
ecletica-1173	145	2	antioxidants	antioxidant	NOUN
ecletica-1173	145	3	become	become	VERB
ecletica-1173	145	4	prooxidants	prooxidant	NOUN
ecletica-1173	145	5	after	after	ADP
ecletica-1173	145	6	exerting	exert	VERB
ecletica-1173	145	7	their	their	PRON
ecletica-1173	145	8	antioxidant	antioxidant	ADJ
ecletica-1173	145	9	effect	effect	NOUN
ecletica-1173	145	10	in	in	ADP
ecletica-1173	145	11	in	in	ADP
ecletica-1173	145	12	vitro	vitro	X
ecletica-1173	145	13	systems	system	NOUN
ecletica-1173	145	14	,	,	PUNCT
ecletica-1173	145	15	pro	pro	ADJ
ecletica-1173	145	16	-	-	ADJ
ecletica-1173	145	17	oxidant	oxidant	ADJ
ecletica-1173	145	18	formation	formation	NOUN
ecletica-1173	145	19	is	be	AUX
ecletica-1173	145	20	rapidly	rapidly	ADV
ecletica-1173	145	21	attenuated	attenuate	VERB
ecletica-1173	145	22	by	by	ADP
ecletica-1173	145	23	recyclable	recyclable	ADJ
ecletica-1173	145	24	chain	chain	NOUN
ecletica-1173	145	25	reactions	reaction	NOUN
ecletica-1173	145	26	involving	involve	VERB
ecletica-1173	145	27	glutathione	glutathione	NOUN
ecletica-1173	145	28	in	in	ADP
ecletica-1173	145	29	the	the	DET
ecletica-1173	145	30	human	human	ADJ
ecletica-1173	145	31	body	body	NOUN
ecletica-1173	145	32	(	(	PUNCT
ecletica-1173	145	33	fojo	fojo	NOUN
ecletica-1173	145	34	,	,	PUNCT
ecletica-1173	145	35	2008	2008	NUM
ecletica-1173	145	36	)	)	PUNCT
ecletica-1173	145	37	.	.	PUNCT
ecletica-1173	146	1	however	however	ADV
ecletica-1173	146	2	,	,	PUNCT
ecletica-1173	146	3	at	at	ADP
ecletica-1173	146	4	a	a	DET
ecletica-1173	146	5	very	very	ADV
ecletica-1173	146	6	high	high	ADJ
ecletica-1173	146	7	dose	dose	NOUN
ecletica-1173	146	8	,	,	PUNCT
ecletica-1173	146	9	antioxidant	antioxidant	ADJ
ecletica-1173	146	10	vitamins	vitamin	NOUN
ecletica-1173	146	11	can	can	AUX
ecletica-1173	146	12	lead	lead	VERB
ecletica-1173	146	13	to	to	ADP
ecletica-1173	146	14	toxic	toxic	ADJ
ecletica-1173	146	15	pro	pro	ADJ
ecletica-1173	146	16	-	-	ADJ
ecletica-1173	146	17	oxidant	oxidant	ADJ
ecletica-1173	146	18	actions	action	NOUN
ecletica-1173	146	19	,	,	PUNCT
ecletica-1173	146	20	indicating	indicate	VERB
ecletica-1173	146	21	the	the	DET
ecletica-1173	146	22	absence	absence	NOUN
ecletica-1173	146	23	of	of	ADP
ecletica-1173	146	24	linear	linear	ADJ
ecletica-1173	146	25	cause	cause	NOUN
ecletica-1173	146	26	and	and	CCONJ
ecletica-1173	146	27	effect	effect	NOUN
ecletica-1173	146	28	association	association	NOUN
ecletica-1173	146	29	.	.	PUNCT
ecletica-1173	147	1	the	the	DET
ecletica-1173	147	2	vitamins	vitamin	NOUN
ecletica-1173	147	3	may	may	AUX
ecletica-1173	147	4	not	not	PART
ecletica-1173	147	5	have	have	VERB
ecletica-1173	147	6	the	the	DET
ecletica-1173	147	7	same	same	ADJ
ecletica-1173	147	8	activity	activity	NOUN
ecletica-1173	147	9	in	in	ADP
ecletica-1173	147	10	crude	crude	ADJ
ecletica-1173	147	11	and	and	CCONJ
ecletica-1173	147	12	characteristic	characteristic	ADJ
ecletica-1173	147	13	foods	food	NOUN
ecletica-1173	147	14	(	(	PUNCT
ecletica-1173	147	15	fardet	fardet	NOUN
ecletica-1173	147	16	and	and	CCONJ
ecletica-1173	147	17	rock	rock	NOUN
ecletica-1173	147	18	,	,	PUNCT
ecletica-1173	147	19	2014	2014	NUM
ecletica-1173	147	20	)	)	PUNCT
ecletica-1173	147	21	.	.	PUNCT
ecletica-1173	148	1	there	there	PRON
ecletica-1173	148	2	is	be	VERB
ecletica-1173	148	3	a	a	DET
ecletica-1173	148	4	demand	demand	NOUN
ecletica-1173	148	5	that	that	SCONJ
ecletica-1173	148	6	the	the	DET
ecletica-1173	148	7	potential	potential	NOUN
ecletica-1173	148	8	for	for	ADP
ecletica-1173	148	9	nourishment	nourishment	NOUN
ecletica-1173	148	10	depends	depend	VERB
ecletica-1173	148	11	on	on	ADP
ecletica-1173	148	12	both	both	CCONJ
ecletica-1173	148	13	supplement	supplement	NOUN
ecletica-1173	148	14	composition	composition	NOUN
ecletica-1173	148	15	and	and	CCONJ
ecletica-1173	148	16	nourishment	nourishment	NOUN
ecletica-1173	148	17	structure	structure	NOUN
ecletica-1173	148	18	properties	property	NOUN
ecletica-1173	148	19	,	,	PUNCT
ecletica-1173	148	20	frequently	frequently	ADV
ecletica-1173	148	21	driving	drive	VERB
ecletica-1173	148	22	to	to	ADP
ecletica-1173	148	23	conflicting	conflicting	ADJ
ecletica-1173	148	24	discoveries	discovery	NOUN
ecletica-1173	148	25	.	.	PUNCT
ecletica-1173	149	1	subsequently	subsequently	ADV
ecletica-1173	149	2	,	,	PUNCT
ecletica-1173	149	3	it	it	PRON
ecletica-1173	149	4	was	be	AUX
ecletica-1173	149	5	expected	expect	VERB
ecletica-1173	149	6	that	that	SCONJ
ecletica-1173	149	7	a	a	DET
ecletica-1173	149	8	more	more	ADV
ecletica-1173	149	9	comprehensive	comprehensive	ADJ
ecletica-1173	149	10	vision	vision	NOUN
ecletica-1173	149	11	of	of	ADP
ecletica-1173	149	12	antioxidant	antioxidant	ADJ
ecletica-1173	149	13	potential	potential	NOUN
ecletica-1173	149	14	would	would	AUX
ecletica-1173	149	15	approach	approach	VERB
ecletica-1173	149	16	a	a	DET
ecletica-1173	149	17	few	few	ADJ
ecletica-1173	149	18	different	different	ADJ
ecletica-1173	149	19	angles	angle	NOUN
ecletica-1173	149	20	of	of	ADP
ecletica-1173	149	21	cancer	cancer	NOUN
ecletica-1173	149	22	prevention	prevention	NOUN
ecletica-1173	149	23	agents	agent	NOUN
ecletica-1173	149	24	with	with	ADP
ecletica-1173	149	25	approaches	approach	NOUN
ecletica-1173	149	26	based	base	VERB
ecletica-1173	149	27	on	on	ADP
ecletica-1173	149	28	synergistic	synergistic	ADJ
ecletica-1173	149	29	,	,	PUNCT
ecletica-1173	149	30	adversarial	adversarial	ADJ
ecletica-1173	149	31	,	,	PUNCT
ecletica-1173	149	32	or	or	CCONJ
ecletica-1173	149	33	multi	multi	ADJ
ecletica-1173	149	34	-	-	NOUN
ecletica-1173	149	35	component	component	ADJ
ecletica-1173	149	36	and	and	CCONJ
ecletica-1173	149	37	multitarget	multitarget	NOUN
ecletica-1173	149	38	additives	additive	NOUN
ecletica-1173	149	39	.	.	PUNCT
ecletica-1173	150	1	examples	example	NOUN
ecletica-1173	150	2	of	of	ADP
ecletica-1173	150	3	reductionism	reductionism	NOUN
ecletica-1173	150	4	at	at	ADP
ecletica-1173	150	5	the	the	DET
ecletica-1173	150	6	biological	biological	ADJ
ecletica-1173	150	7	level	level	NOUN
ecletica-1173	150	8	and	and	CCONJ
ecletica-1173	150	9	its	its	PRON
ecletica-1173	150	10	implications	implication	NOUN
ecletica-1173	150	11	are	be	AUX
ecletica-1173	150	12	common	common	ADJ
ecletica-1173	150	13	.	.	PUNCT
ecletica-1173	151	1	here	here	ADV
ecletica-1173	151	2	,	,	PUNCT
ecletica-1173	151	3	diseases	disease	NOUN
ecletica-1173	151	4	and	and	CCONJ
ecletica-1173	151	5	health	health	NOUN
ecletica-1173	151	6	problems	problem	NOUN
ecletica-1173	151	7	are	be	AUX
ecletica-1173	151	8	reduced	reduce	VERB
ecletica-1173	151	9	to	to	ADP
ecletica-1173	151	10	biological	biological	ADJ
ecletica-1173	151	11	molecules	molecule	NOUN
ecletica-1173	151	12	,	,	PUNCT
ecletica-1173	151	13	such	such	ADJ
ecletica-1173	151	14	as	as	ADP
ecletica-1173	151	15	dna	dna	PROPN
ecletica-1173	151	16	,	,	PUNCT
ecletica-1173	151	17	rna	rna	NOUN
ecletica-1173	151	18	,	,	PUNCT
ecletica-1173	151	19	and	and	CCONJ
ecletica-1173	151	20	specific	specific	ADJ
ecletica-1173	151	21	enzymes	enzyme	NOUN
ecletica-1173	151	22	.	.	PUNCT
ecletica-1173	152	1	it	it	PRON
ecletica-1173	152	2	is	be	AUX
ecletica-1173	152	3	necessary	necessary	ADJ
ecletica-1173	152	4	to	to	PART
ecletica-1173	152	5	know	know	VERB
ecletica-1173	152	6	biological	biological	ADJ
ecletica-1173	152	7	targets	target	NOUN
ecletica-1173	152	8	for	for	ADP
ecletica-1173	152	9	the	the	DET
ecletica-1173	152	10	synthesis	synthesis	NOUN
ecletica-1173	152	11	of	of	ADP
ecletica-1173	152	12	new	new	ADJ
ecletica-1173	152	13	drugs	drug	NOUN
ecletica-1173	152	14	.	.	PUNCT
ecletica-1173	153	1	there	there	PRON
ecletica-1173	153	2	is	be	VERB
ecletica-1173	153	3	yet	yet	ADV
ecletica-1173	153	4	a	a	DET
ecletica-1173	153	5	technological	technological	ADJ
ecletica-1173	153	6	obstacle	obstacle	NOUN
ecletica-1173	153	7	that	that	PRON
ecletica-1173	153	8	prevents	prevent	VERB
ecletica-1173	153	9	the	the	DET
ecletica-1173	153	10	study	study	NOUN
ecletica-1173	153	11	of	of	ADP
ecletica-1173	153	12	the	the	DET
ecletica-1173	153	13	system	system	NOUN
ecletica-1173	153	14	as	as	ADP
ecletica-1173	153	15	a	a	DET
ecletica-1173	153	16	whole	whole	NOUN
ecletica-1173	153	17	.	.	PUNCT
ecletica-1173	154	1	in	in	ADP
ecletica-1173	154	2	this	this	DET
ecletica-1173	154	3	way	way	NOUN
ecletica-1173	154	4	,	,	PUNCT
ecletica-1173	154	5	methodological	methodological	ADJ
ecletica-1173	154	6	reductionism	reductionism	NOUN
ecletica-1173	154	7	must	must	AUX
ecletica-1173	154	8	be	be	AUX
ecletica-1173	154	9	comprehended	comprehend	VERB
ecletica-1173	154	10	as	as	ADP
ecletica-1173	154	11	a	a	DET
ecletica-1173	154	12	step	step	NOUN
ecletica-1173	154	13	to	to	PART
ecletica-1173	154	14	reach	reach	VERB
ecletica-1173	154	15	ontological	ontological	ADJ
ecletica-1173	154	16	holism	holism	NOUN
ecletica-1173	154	17	.	.	PUNCT
ecletica-1173	155	1	however	however	ADV
ecletica-1173	155	2	,	,	PUNCT
ecletica-1173	155	3	a	a	DET
ecletica-1173	155	4	new	new	ADJ
ecletica-1173	155	5	type	type	NOUN
ecletica-1173	155	6	of	of	ADP
ecletica-1173	155	7	reductionism	reductionism	NOUN
ecletica-1173	155	8	is	be	AUX
ecletica-1173	155	9	noted	note	VERB
ecletica-1173	155	10	when	when	SCONJ
ecletica-1173	155	11	scientists	scientist	NOUN
ecletica-1173	155	12	reduce	reduce	VERB
ecletica-1173	155	13	the	the	DET
ecletica-1173	155	14	problem	problem	NOUN
ecletica-1173	155	15	to	to	ADP
ecletica-1173	155	16	simple	simple	ADJ
ecletica-1173	155	17	molecules	molecule	NOUN
ecletica-1173	155	18	.	.	PUNCT
ecletica-1173	156	1	5	5	X
ecletica-1173	156	2	.	.	X
ecletica-1173	156	3	chemical	chemical	ADJ
ecletica-1173	156	4	reductionism	reductionism	NOUN
ecletica-1173	156	5	modern	modern	ADJ
ecletica-1173	156	6	chemistry	chemistry	NOUN
ecletica-1173	156	7	was	be	AUX
ecletica-1173	156	8	born	bear	VERB
ecletica-1173	156	9	with	with	ADP
ecletica-1173	156	10	lavoisier	lavoisier	NOUN
ecletica-1173	156	11	’s	’s	PART
ecletica-1173	156	12	quantitative	quantitative	ADJ
ecletica-1173	156	13	studies	study	NOUN
ecletica-1173	156	14	.	.	PUNCT
ecletica-1173	157	1	on	on	ADP
ecletica-1173	157	2	the	the	DET
ecletica-1173	157	3	other	other	ADJ
ecletica-1173	157	4	hand	hand	NOUN
ecletica-1173	157	5	,	,	PUNCT
ecletica-1173	157	6	biology	biology	NOUN
ecletica-1173	157	7	has	have	AUX
ecletica-1173	157	8	been	be	AUX
ecletica-1173	157	9	developed	develop	VERB
ecletica-1173	157	10	since	since	SCONJ
ecletica-1173	157	11	classical	classical	ADJ
ecletica-1173	157	12	antiquity	antiquity	NOUN
ecletica-1173	157	13	.	.	PUNCT
ecletica-1173	158	1	aristotle	aristotle	PROPN
ecletica-1173	158	2	had	have	VERB
ecletica-1173	158	3	manuscripts	manuscript	NOUN
ecletica-1173	158	4	classifying	classify	VERB
ecletica-1173	158	5	the	the	DET
ecletica-1173	158	6	living	live	VERB
ecletica-1173	158	7	beings	being	NOUN
ecletica-1173	158	8	.	.	PUNCT
ecletica-1173	159	1	nowadays	nowadays	ADV
ecletica-1173	159	2	there	there	PRON
ecletica-1173	159	3	is	be	VERB
ecletica-1173	159	4	a	a	DET
ecletica-1173	159	5	particular	particular	ADJ
ecletica-1173	159	6	branch	branch	NOUN
ecletica-1173	159	7	or	or	CCONJ
ecletica-1173	159	8	knowledge	knowledge	NOUN
ecletica-1173	159	9	shared	share	VERB
ecletica-1173	159	10	by	by	ADP
ecletica-1173	159	11	chemistry	chemistry	NOUN
ecletica-1173	159	12	and	and	CCONJ
ecletica-1173	159	13	biology	biology	NOUN
ecletica-1173	159	14	.	.	PUNCT
ecletica-1173	160	1	these	these	DET
ecletica-1173	160	2	sciences	science	NOUN
ecletica-1173	160	3	use	use	VERB
ecletica-1173	160	4	methodologies	methodology	NOUN
ecletica-1173	160	5	derivative	derivative	ADJ
ecletica-1173	160	6	from	from	ADP
ecletica-1173	160	7	biochemistry	biochemistry	NOUN
ecletica-1173	160	8	.	.	PUNCT
ecletica-1173	161	1	the	the	DET
ecletica-1173	161	2	studies	study	NOUN
ecletica-1173	161	3	in	in	ADP
ecletica-1173	161	4	both	both	DET
ecletica-1173	161	5	disciplines	discipline	NOUN
ecletica-1173	161	6	start	start	VERB
ecletica-1173	161	7	by	by	ADP
ecletica-1173	161	8	creating	create	VERB
ecletica-1173	161	9	rigorous	rigorous	ADJ
ecletica-1173	161	10	tests	test	NOUN
ecletica-1173	161	11	to	to	PART
ecletica-1173	161	12	study	study	VERB
ecletica-1173	161	13	molecules	molecule	NOUN
ecletica-1173	161	14	,	,	PUNCT
ecletica-1173	161	15	genes	gene	NOUN
ecletica-1173	161	16	or	or	CCONJ
ecletica-1173	161	17	proteins	protein	NOUN
ecletica-1173	161	18	.	.	PUNCT
ecletica-1173	162	1	however	however	ADV
ecletica-1173	162	2	,	,	PUNCT
ecletica-1173	162	3	the	the	DET
ecletica-1173	162	4	targets	target	NOUN
ecletica-1173	162	5	are	be	AUX
ecletica-1173	162	6	remarkably	remarkably	ADV
ecletica-1173	162	7	diverse	diverse	ADJ
ecletica-1173	162	8	in	in	ADP
ecletica-1173	162	9	both	both	DET
ecletica-1173	162	10	disciplines	discipline	NOUN
ecletica-1173	162	11	.	.	PUNCT
ecletica-1173	163	1	biological	biological	ADJ
ecletica-1173	163	2	systems	system	NOUN
ecletica-1173	163	3	use	use	VERB
ecletica-1173	163	4	the	the	DET
ecletica-1173	163	5	comparison	comparison	NOUN
ecletica-1173	163	6	between	between	ADP
ecletica-1173	163	7	two	two	NUM
ecletica-1173	163	8	systems	system	NOUN
ecletica-1173	163	9	to	to	PART
ecletica-1173	163	10	understand	understand	VERB
ecletica-1173	163	11	connections	connection	NOUN
ecletica-1173	163	12	,	,	PUNCT
ecletica-1173	163	13	uncovering	uncover	VERB
ecletica-1173	163	14	tall	tall	ADJ
ecletica-1173	163	15	arrangements	arrangement	NOUN
ecletica-1173	163	16	in	in	ADP
ecletica-1173	163	17	organized	organized	ADJ
ecletica-1173	163	18	structures	structure	NOUN
ecletica-1173	163	19	and	and	CCONJ
ecletica-1173	163	20	modeling	model	VERB
ecletica-1173	163	21	complexity	complexity	NOUN
ecletica-1173	163	22	.	.	PUNCT
ecletica-1173	164	1	on	on	ADP
ecletica-1173	164	2	the	the	DET
ecletica-1173	164	3	other	other	ADJ
ecletica-1173	164	4	hand	hand	NOUN
ecletica-1173	164	5	,	,	PUNCT
ecletica-1173	164	6	biochemistry	biochemistry	NOUN
ecletica-1173	164	7	is	be	AUX
ecletica-1173	164	8	ruled	rule	VERB
ecletica-1173	164	9	by	by	ADP
ecletica-1173	164	10	the	the	DET
ecletica-1173	164	11	attitude	attitude	NOUN
ecletica-1173	164	12	of	of	ADP
ecletica-1173	164	13	matching	match	VERB
ecletica-1173	164	14	pairing	pair	VERB
ecletica-1173	164	15	individual	individual	ADJ
ecletica-1173	164	16	compounds	compound	NOUN
ecletica-1173	164	17	and	and	CCONJ
ecletica-1173	164	18	molecular	molecular	ADJ
ecletica-1173	164	19	targets	target	NOUN
ecletica-1173	164	20	.	.	PUNCT
ecletica-1173	165	1	as	as	ADP
ecletica-1173	165	2	a	a	DET
ecletica-1173	165	3	result	result	NOUN
ecletica-1173	165	4	,	,	PUNCT
ecletica-1173	165	5	efficient	efficient	ADJ
ecletica-1173	165	6	biochemistry	biochemistry	NOUN
ecletica-1173	165	7	ponders	ponder	NOUN
ecletica-1173	165	8	are	be	AUX
ecletica-1173	165	9	frequently	frequently	ADV
ecletica-1173	165	10	centered	center	VERB
ecletica-1173	165	11	on	on	ADP
ecletica-1173	165	12	query	query	NOUN
ecletica-1173	165	13	databases	database	NOUN
ecletica-1173	165	14	to	to	PART
ecletica-1173	165	15	recognize	recognize	VERB
ecletica-1173	165	16	interactions	interaction	NOUN
ecletica-1173	165	17	between	between	ADP
ecletica-1173	165	18	particular	particular	ADJ
ecletica-1173	165	19	molecules	molecule	NOUN
ecletica-1173	165	20	and	and	CCONJ
ecletica-1173	165	21	a	a	DET
ecletica-1173	165	22	single	single	ADJ
ecletica-1173	165	23	target	target	NOUN
ecletica-1173	165	24	.	.	PUNCT
ecletica-1173	166	1	in	in	ADP
ecletica-1173	166	2	general	general	ADJ
ecletica-1173	166	3	,	,	PUNCT
ecletica-1173	166	4	the	the	DET
ecletica-1173	166	5	salicylic	salicylic	ADJ
ecletica-1173	166	6	acid	acid	NOUN
ecletica-1173	166	7	is	be	AUX
ecletica-1173	166	8	described	describe	VERB
ecletica-1173	166	9	as	as	ADP
ecletica-1173	166	10	a	a	DET
ecletica-1173	166	11	cyclooxygenase	cyclooxygenase	NOUN
ecletica-1173	166	12	(	(	PUNCT
ecletica-1173	166	13	cox	cox	PROPN
ecletica-1173	166	14	)	)	PUNCT
ecletica-1173	166	15	(	(	PUNCT
ecletica-1173	166	16	fig	fig	NOUN
ecletica-1173	166	17	.	.	NOUN
ecletica-1173	166	18	1	1	NUM
ecletica-1173	166	19	)	)	PUNCT
ecletica-1173	166	20	inhibitor	inhibitor	NOUN
ecletica-1173	166	21	,	,	PUNCT
ecletica-1173	166	22	atorvastatin	atorvastatin	NOUN
ecletica-1173	166	23	as	as	ADP
ecletica-1173	166	24	a	a	DET
ecletica-1173	166	25	3	3	NUM
ecletica-1173	166	26	-	-	PUNCT
ecletica-1173	166	27	hydroxy-3	hydroxy-3	NUM
ecletica-1173	166	28	-	-	PUNCT
ecletica-1173	166	29	methylglutaryl	methylglutaryl	NOUN
ecletica-1173	166	30	(	(	PUNCT
ecletica-1173	166	31	hmg	hmg	NOUN
ecletica-1173	166	32	)	)	PUNCT
ecletica-1173	166	33	coenzyme	coenzyme	PROPN
ecletica-1173	166	34	a	a	DET
ecletica-1173	166	35	reductase	reductase	NOUN
ecletica-1173	166	36	inhibitor	inhibitor	NOUN
ecletica-1173	166	37	and	and	CCONJ
ecletica-1173	166	38	lithium	lithium	NOUN
ecletica-1173	166	39	as	as	ADP
ecletica-1173	166	40	a	a	DET
ecletica-1173	166	41	glycogen	glycogen	NOUN
ecletica-1173	166	42	synthase	synthase	NOUN
ecletica-1173	166	43	kinase	kinase	PROPN
ecletica-1173	166	44	3β	3β	NUM
ecletica-1173	166	45	(	(	PUNCT
ecletica-1173	166	46	gsk3β	gsk3β	PROPN
ecletica-1173	166	47	)	)	PUNCT
ecletica-1173	166	48	inhibitor	inhibitor	NOUN
ecletica-1173	166	49	.	.	PUNCT
ecletica-1173	167	1	figure	figure	NOUN
ecletica-1173	167	2	1	1	NUM
ecletica-1173	167	3	.	.	PUNCT
ecletica-1173	167	4	salicylic	salicylic	ADJ
ecletica-1173	167	5	acid	acid	PROPN
ecletica-1173	167	6	interacting	interact	VERB
ecletica-1173	167	7	with	with	ADP
ecletica-1173	167	8	cyclooxygenase	cyclooxygenase	NOUN
ecletica-1173	167	9	site	site	NOUN
ecletica-1173	167	10	.	.	PUNCT
ecletica-1173	168	1	structure	structure	NOUN
ecletica-1173	168	2	obtained	obtain	VERB
ecletica-1173	168	3	from	from	ADP
ecletica-1173	168	4	5f1a	5f1a	PROPN
ecletica-1173	168	5	(	(	PUNCT
ecletica-1173	168	6	the	the	DET
ecletica-1173	168	7	crystal	crystal	NOUN
ecletica-1173	168	8	structure	structure	NOUN
ecletica-1173	168	9	of	of	ADP
ecletica-1173	168	10	salicylate	salicylate	NOUN
ecletica-1173	168	11	bound	bind	VERB
ecletica-1173	168	12	to	to	ADP
ecletica-1173	168	13	human	human	ADJ
ecletica-1173	168	14	cyclooxygenase-2	cyclooxygenase-2	NOUN
ecletica-1173	168	15	/	/	SYM
ecletica-1173	168	16	protein	protein	NOUN
ecletica-1173	168	17	data	datum	NOUN
ecletica-1173	168	18	bank	bank	PROPN
ecletica-1173	168	19	)	)	PUNCT
ecletica-1173	168	20	.	.	PUNCT
ecletica-1173	169	1	these	these	DET
ecletica-1173	169	2	descriptors	descriptor	NOUN
ecletica-1173	169	3	are	be	AUX
ecletica-1173	169	4	useful	useful	ADJ
ecletica-1173	169	5	and	and	CCONJ
ecletica-1173	169	6	carry	carry	VERB
ecletica-1173	169	7	some	some	DET
ecletica-1173	169	8	information	information	NOUN
ecletica-1173	169	9	,	,	PUNCT
ecletica-1173	169	10	but	but	CCONJ
ecletica-1173	169	11	,	,	PUNCT
ecletica-1173	169	12	in	in	ADP
ecletica-1173	169	13	reality	reality	NOUN
ecletica-1173	169	14	,	,	PUNCT
ecletica-1173	169	15	these	these	DET
ecletica-1173	169	16	small	small	ADJ
ecletica-1173	169	17	molecules	molecule	NOUN
ecletica-1173	169	18	do	do	VERB
ecletica-1173	169	19	much	much	ADV
ecletica-1173	169	20	more	more	ADJ
ecletica-1173	169	21	than	than	SCONJ
ecletica-1173	169	22	inhibit	inhibit	VERB
ecletica-1173	169	23	a	a	DET
ecletica-1173	169	24	single	single	ADJ
ecletica-1173	169	25	enzyme	enzyme	NOUN
ecletica-1173	169	26	.	.	PUNCT
ecletica-1173	170	1	the	the	DET
ecletica-1173	170	2	benefits	benefit	NOUN
ecletica-1173	170	3	and	and	CCONJ
ecletica-1173	170	4	negative	negative	ADJ
ecletica-1173	170	5	effects	effect	NOUN
ecletica-1173	170	6	on	on	ADP
ecletica-1173	170	7	humans	human	NOUN
ecletica-1173	170	8	are	be	AUX
ecletica-1173	170	9	not	not	PART
ecletica-1173	170	10	fully	fully	ADV
ecletica-1173	170	11	explained	explain	VERB
ecletica-1173	170	12	http://revista.iq.unesp.br/ojs/index.php/ecletica/index	http://revista.iq.unesp.br/ojs/index.php/ecletica/index	NOUN
ecletica-1173	170	13	https://doi.org/10.26850/1678-4618eqj.v46.3.2021.p17-32	https://doi.org/10.26850/1678-4618eqj.v46.3.2021.p17-32	PROPN
ecletica-1173	170	14	review	review	NOUN
ecletica-1173	170	15	article	article	NOUN
ecletica-1173	170	16	iq.unesp.br/ecletica	iq.unesp.br/ecletica	PROPN
ecletica-1173	170	17	22	22	NUM
ecletica-1173	170	18	eclética	eclética	PROPN
ecletica-1173	170	19	química	química	PROPN
ecletica-1173	170	20	journal	journal	PROPN
ecletica-1173	170	21	,	,	PUNCT
ecletica-1173	170	22	vol	vol	NOUN
ecletica-1173	170	23	.	.	PROPN
ecletica-1173	170	24	46	46	NUM
ecletica-1173	170	25	,	,	PUNCT
ecletica-1173	170	26	n.	n.	NOUN
ecletica-1173	170	27	3	3	NUM
ecletica-1173	170	28	,	,	PUNCT
ecletica-1173	170	29	2021	2021	NUM
ecletica-1173	170	30	,	,	PUNCT
ecletica-1173	170	31	17	17	NUM
ecletica-1173	170	32	-	-	SYM
ecletica-1173	170	33	32	32	NUM
ecletica-1173	170	34	issn	issn	NOUN
ecletica-1173	170	35	:	:	PUNCT
ecletica-1173	170	36	1678	1678	NUM
ecletica-1173	170	37	-	-	SYM
ecletica-1173	170	38	4618	4618	NUM
ecletica-1173	170	39	doi	doi	NOUN
ecletica-1173	170	40	:	:	PUNCT
ecletica-1173	170	41	10.26850/1678	10.26850/1678	NUM
ecletica-1173	170	42	-	-	SYM
ecletica-1173	170	43	4618eqj.v46.3.2021.p17	4618eqj.v46.3.2021.p17	NOUN
ecletica-1173	170	44	-	-	PUNCT
ecletica-1173	170	45	32	32	NUM
ecletica-1173	170	46	by	by	ADP
ecletica-1173	170	47	their	their	PRON
ecletica-1173	170	48	actions	action	NOUN
ecletica-1173	170	49	on	on	ADP
ecletica-1173	170	50	a	a	DET
ecletica-1173	170	51	single	single	ADJ
ecletica-1173	170	52	enzyme	enzyme	NOUN
ecletica-1173	170	53	.	.	PUNCT
ecletica-1173	171	1	it	it	PRON
ecletica-1173	171	2	is	be	AUX
ecletica-1173	171	3	important	important	ADJ
ecletica-1173	171	4	to	to	PART
ecletica-1173	171	5	invoke	invoke	VERB
ecletica-1173	171	6	a	a	DET
ecletica-1173	171	7	holism	holism	NOUN
ecletica-1173	171	8	view	view	NOUN
ecletica-1173	171	9	of	of	ADP
ecletica-1173	171	10	the	the	DET
ecletica-1173	171	11	system	system	NOUN
ecletica-1173	171	12	.	.	PUNCT
ecletica-1173	172	1	selective	selective	ADJ
ecletica-1173	172	2	kinase	kinase	PROPN
ecletica-1173	172	3	inhibitors	inhibitor	NOUN
ecletica-1173	172	4	in	in	ADP
ecletica-1173	172	5	clinical	clinical	ADJ
ecletica-1173	172	6	oncology	oncology	NOUN
ecletica-1173	172	7	were	be	AUX
ecletica-1173	172	8	the	the	DET
ecletica-1173	172	9	main	main	ADJ
ecletica-1173	172	10	goal	goal	NOUN
ecletica-1173	172	11	of	of	ADP
ecletica-1173	172	12	research	research	NOUN
ecletica-1173	172	13	a	a	DET
ecletica-1173	172	14	decade	decade	NOUN
ecletica-1173	172	15	ago	ago	ADV
ecletica-1173	172	16	.	.	PUNCT
ecletica-1173	173	1	however	however	ADV
ecletica-1173	173	2	,	,	PUNCT
ecletica-1173	173	3	many	many	ADJ
ecletica-1173	173	4	experts	expert	NOUN
ecletica-1173	173	5	now	now	ADV
ecletica-1173	173	6	believe	believe	VERB
ecletica-1173	173	7	that	that	SCONJ
ecletica-1173	173	8	kinase	kinase	PROPN
ecletica-1173	173	9	inhibitors	inhibitor	NOUN
ecletica-1173	173	10	may	may	AUX
ecletica-1173	173	11	be	be	AUX
ecletica-1173	173	12	advantageous	advantageous	ADJ
ecletica-1173	173	13	in	in	ADP
ecletica-1173	173	14	treating	treat	VERB
ecletica-1173	173	15	cancer	cancer	NOUN
ecletica-1173	173	16	due	due	ADP
ecletica-1173	173	17	to	to	ADP
ecletica-1173	173	18	the	the	DET
ecletica-1173	173	19	multi	multi	ADJ
ecletica-1173	173	20	target	target	NOUN
ecletica-1173	173	21	reached	reach	VERB
ecletica-1173	173	22	by	by	ADP
ecletica-1173	173	23	these	these	DET
ecletica-1173	173	24	kinds	kind	NOUN
ecletica-1173	173	25	of	of	ADP
ecletica-1173	173	26	molecules	molecule	NOUN
ecletica-1173	173	27	.	.	PUNCT
ecletica-1173	174	1	however	however	ADV
ecletica-1173	174	2	,	,	PUNCT
ecletica-1173	174	3	the	the	DET
ecletica-1173	174	4	rational	rational	ADJ
ecletica-1173	174	5	drug	drug	NOUN
ecletica-1173	174	6	design	design	NOUN
ecletica-1173	174	7	continues	continue	VERB
ecletica-1173	174	8	to	to	PART
ecletica-1173	174	9	follow	follow	VERB
ecletica-1173	174	10	the	the	DET
ecletica-1173	174	11	idea	idea	NOUN
ecletica-1173	174	12	that	that	SCONJ
ecletica-1173	174	13	“	"	PUNCT
ecletica-1173	174	14	cell	cell	NOUN
ecletica-1173	174	15	life	life	NOUN
ecletica-1173	174	16	is	be	AUX
ecletica-1173	174	17	closely	closely	ADV
ecletica-1173	174	18	linked	link	VERB
ecletica-1173	174	19	to	to	ADP
ecletica-1173	174	20	a	a	DET
ecletica-1173	174	21	large	large	ADJ
ecletica-1173	174	22	number	number	NOUN
ecletica-1173	174	23	of	of	ADP
ecletica-1173	174	24	specific	specific	ADJ
ecletica-1173	174	25	and	and	CCONJ
ecletica-1173	174	26	selective	selective	ADJ
ecletica-1173	174	27	interactions	interaction	NOUN
ecletica-1173	174	28	between	between	ADP
ecletica-1173	174	29	bio	bio	NOUN
ecletica-1173	174	30	macromolecules	macromolecule	NOUN
ecletica-1173	174	31	”	"	PUNCT
ecletica-1173	174	32	(	(	PUNCT
ecletica-1173	174	33	cheng	cheng	PROPN
ecletica-1173	174	34	et	et	PROPN
ecletica-1173	174	35	al	al	PROPN
ecletica-1173	174	36	.	.	PROPN
ecletica-1173	174	37	,	,	PUNCT
ecletica-1173	174	38	2012	2012	NUM
ecletica-1173	174	39	;	;	PUNCT
ecletica-1173	174	40	cavasotto	cavasotto	PROPN
ecletica-1173	174	41	et	et	PROPN
ecletica-1173	174	42	al	al	PROPN
ecletica-1173	174	43	.	.	PROPN
ecletica-1173	174	44	,	,	PUNCT
ecletica-1173	174	45	2018	2018	NUM
ecletica-1173	174	46	)	)	PUNCT
ecletica-1173	174	47	.	.	PUNCT
ecletica-1173	175	1	macromolecular	macromolecular	NOUN
ecletica-1173	175	2	modeling	modeling	NOUN
ecletica-1173	175	3	by	by	ADP
ecletica-1173	175	4	docking	dock	VERB
ecletica-1173	175	5	studies	study	NOUN
ecletica-1173	175	6	provides	provide	VERB
ecletica-1173	175	7	drug	drug	NOUN
ecletica-1173	175	8	-	-	PUNCT
ecletica-1173	175	9	receptor	receptor	NOUN
ecletica-1173	175	10	interaction	interaction	NOUN
ecletica-1173	175	11	.	.	PUNCT
ecletica-1173	176	1	in	in	ADP
ecletica-1173	176	2	this	this	DET
ecletica-1173	176	3	approach	approach	NOUN
ecletica-1173	176	4	,	,	PUNCT
ecletica-1173	176	5	the	the	DET
ecletica-1173	176	6	drug	drug	NOUN
ecletica-1173	176	7	structure	structure	NOUN
ecletica-1173	176	8	is	be	AUX
ecletica-1173	176	9	designed	design	VERB
ecletica-1173	176	10	based	base	VERB
ecletica-1173	176	11	on	on	ADP
ecletica-1173	176	12	its	its	PRON
ecletica-1173	176	13	3d	3d	NOUN
ecletica-1173	176	14	adjustment	adjustment	NOUN
ecletica-1173	176	15	to	to	ADP
ecletica-1173	176	16	the	the	DET
ecletica-1173	176	17	receptor	receptor	NOUN
ecletica-1173	176	18	site	site	NOUN
ecletica-1173	176	19	structure	structure	NOUN
ecletica-1173	176	20	(	(	PUNCT
ecletica-1173	176	21	aucar	aucar	NOUN
ecletica-1173	176	22	and	and	CCONJ
ecletica-1173	176	23	cavasotto	cavasotto	NOUN
ecletica-1173	176	24	,	,	PUNCT
ecletica-1173	176	25	2020	2020	NUM
ecletica-1173	176	26	)	)	PUNCT
ecletica-1173	176	27	.	.	PUNCT
ecletica-1173	177	1	a	a	DET
ecletica-1173	177	2	clear	clear	ADJ
ecletica-1173	177	3	example	example	NOUN
ecletica-1173	177	4	is	be	AUX
ecletica-1173	177	5	the	the	DET
ecletica-1173	177	6	inhibitors	inhibitor	NOUN
ecletica-1173	177	7	of	of	ADP
ecletica-1173	177	8	enzyme	enzyme	NOUN
ecletica-1173	177	9	kinase	kinase	NOUN
ecletica-1173	177	10	.	.	PUNCT
ecletica-1173	178	1	kinases	kinase	NOUN
ecletica-1173	178	2	are	be	AUX
ecletica-1173	178	3	enzymes	enzyme	NOUN
ecletica-1173	178	4	associated	associate	VERB
ecletica-1173	178	5	with	with	ADP
ecletica-1173	178	6	the	the	DET
ecletica-1173	178	7	biochemical	biochemical	ADJ
ecletica-1173	178	8	process	process	NOUN
ecletica-1173	178	9	known	know	VERB
ecletica-1173	178	10	as	as	ADP
ecletica-1173	178	11	signal	signal	ADJ
ecletica-1173	178	12	transduction	transduction	NOUN
ecletica-1173	178	13	.	.	PUNCT
ecletica-1173	179	1	in	in	ADP
ecletica-1173	179	2	this	this	DET
ecletica-1173	179	3	process	process	NOUN
ecletica-1173	179	4	,	,	PUNCT
ecletica-1173	179	5	the	the	DET
ecletica-1173	179	6	enzyme	enzyme	NOUN
ecletica-1173	179	7	kinase	kinase	NOUN
ecletica-1173	179	8	catalyzes	catalyze	VERB
ecletica-1173	179	9	phosphorylation	phosphorylation	NOUN
ecletica-1173	179	10	reactions	reaction	NOUN
ecletica-1173	179	11	of	of	ADP
ecletica-1173	179	12	other	other	ADJ
ecletica-1173	179	13	enzymes	enzyme	NOUN
ecletica-1173	179	14	.	.	PUNCT
ecletica-1173	180	1	this	this	DET
ecletica-1173	180	2	biochemical	biochemical	ADJ
ecletica-1173	180	3	process	process	NOUN
ecletica-1173	180	4	triggers	trigger	VERB
ecletica-1173	180	5	a	a	DET
ecletica-1173	180	6	cascade	cascade	NOUN
ecletica-1173	180	7	of	of	ADP
ecletica-1173	180	8	chemical	chemical	NOUN
ecletica-1173	180	9	signals	signal	NOUN
ecletica-1173	180	10	that	that	PRON
ecletica-1173	180	11	are	be	AUX
ecletica-1173	180	12	converted	convert	VERB
ecletica-1173	180	13	into	into	ADP
ecletica-1173	180	14	physical	physical	ADJ
ecletica-1173	180	15	responses	response	NOUN
ecletica-1173	180	16	by	by	ADP
ecletica-1173	180	17	the	the	DET
ecletica-1173	180	18	cell	cell	NOUN
ecletica-1173	180	19	.	.	PUNCT
ecletica-1173	181	1	in	in	ADP
ecletica-1173	181	2	this	this	DET
ecletica-1173	181	3	case	case	NOUN
ecletica-1173	181	4	,	,	PUNCT
ecletica-1173	181	5	the	the	DET
ecletica-1173	181	6	target	target	NOUN
ecletica-1173	181	7	protein	protein	NOUN
ecletica-1173	181	8	is	be	AUX
ecletica-1173	181	9	chosen	choose	VERB
ecletica-1173	181	10	for	for	ADP
ecletica-1173	181	11	the	the	DET
ecletica-1173	181	12	first	first	ADJ
ecletica-1173	181	13	step	step	NOUN
ecletica-1173	181	14	of	of	ADP
ecletica-1173	181	15	rational	rational	ADJ
ecletica-1173	181	16	drug	drug	NOUN
ecletica-1173	181	17	design	design	NOUN
ecletica-1173	181	18	.	.	PUNCT
ecletica-1173	182	1	at	at	ADP
ecletica-1173	182	2	this	this	DET
ecletica-1173	182	3	stage	stage	NOUN
ecletica-1173	182	4	,	,	PUNCT
ecletica-1173	182	5	the	the	DET
ecletica-1173	182	6	drug	drug	NOUN
ecletica-1173	182	7	is	be	AUX
ecletica-1173	182	8	designed	design	VERB
ecletica-1173	182	9	in	in	ADP
ecletica-1173	182	10	order	order	NOUN
ecletica-1173	182	11	to	to	PART
ecletica-1173	182	12	mimic	mimic	VERB
ecletica-1173	182	13	the	the	DET
ecletica-1173	182	14	structure	structure	NOUN
ecletica-1173	182	15	of	of	ADP
ecletica-1173	182	16	the	the	DET
ecletica-1173	182	17	adenosine	adenosine	NOUN
ecletica-1173	182	18	triphosphate	triphosphate	NOUN
ecletica-1173	182	19	(	(	PUNCT
ecletica-1173	182	20	atp	atp	NOUN
ecletica-1173	182	21	)	)	PUNCT
ecletica-1173	182	22	molecule	molecule	NOUN
ecletica-1173	182	23	.	.	PUNCT
ecletica-1173	183	1	the	the	DET
ecletica-1173	183	2	premise	premise	NOUN
ecletica-1173	183	3	is	be	AUX
ecletica-1173	183	4	that	that	SCONJ
ecletica-1173	183	5	the	the	DET
ecletica-1173	183	6	drug	drug	NOUN
ecletica-1173	183	7	must	must	AUX
ecletica-1173	183	8	have	have	VERB
ecletica-1173	183	9	atp	atp	NOUN
ecletica-1173	183	10	-	-	PUNCT
ecletica-1173	183	11	common	common	ADJ
ecletica-1173	183	12	pharmacophoric	pharmacophoric	ADJ
ecletica-1173	183	13	groups	group	NOUN
ecletica-1173	183	14	in	in	ADP
ecletica-1173	183	15	order	order	NOUN
ecletica-1173	183	16	to	to	PART
ecletica-1173	183	17	inhibit	inhibit	VERB
ecletica-1173	183	18	enzyme	enzyme	NOUN
ecletica-1173	183	19	activity	activity	NOUN
ecletica-1173	183	20	through	through	ADP
ecletica-1173	183	21	the	the	DET
ecletica-1173	183	22	induced	induced	ADJ
ecletica-1173	183	23	docking	docking	NOUN
ecletica-1173	183	24	model	model	NOUN
ecletica-1173	183	25	proposed	propose	VERB
ecletica-1173	183	26	by	by	ADP
ecletica-1173	183	27	koshland	koshland	PROPN
ecletica-1173	183	28	(	(	PUNCT
ecletica-1173	183	29	1958	1958	NUM
ecletica-1173	183	30	)	)	PUNCT
ecletica-1173	183	31	.	.	PUNCT
ecletica-1173	184	1	in	in	ADP
ecletica-1173	184	2	this	this	DET
ecletica-1173	184	3	model	model	NOUN
ecletica-1173	184	4	,	,	PUNCT
ecletica-1173	184	5	the	the	DET
ecletica-1173	184	6	substrate	substrate	NOUN
ecletica-1173	184	7	is	be	AUX
ecletica-1173	184	8	able	able	ADJ
ecletica-1173	184	9	to	to	PART
ecletica-1173	184	10	adapt	adapt	VERB
ecletica-1173	184	11	to	to	ADP
ecletica-1173	184	12	changes	change	NOUN
ecletica-1173	184	13	in	in	ADP
ecletica-1173	184	14	enzyme	enzyme	NOUN
ecletica-1173	184	15	conformation	conformation	NOUN
ecletica-1173	184	16	.	.	PUNCT
ecletica-1173	185	1	this	this	DET
ecletica-1173	185	2	idea	idea	NOUN
ecletica-1173	185	3	permeates	permeate	VERB
ecletica-1173	185	4	the	the	DET
ecletica-1173	185	5	construction	construction	NOUN
ecletica-1173	185	6	of	of	ADP
ecletica-1173	185	7	new	new	ADJ
ecletica-1173	185	8	drugs	drug	NOUN
ecletica-1173	185	9	aimed	aim	VERB
ecletica-1173	185	10	at	at	ADP
ecletica-1173	185	11	cancer	cancer	NOUN
ecletica-1173	185	12	treatment	treatment	NOUN
ecletica-1173	185	13	(	(	PUNCT
ecletica-1173	185	14	akhtar	akhtar	PROPN
ecletica-1173	185	15	et	et	PROPN
ecletica-1173	185	16	al	al	PROPN
ecletica-1173	185	17	.	.	PROPN
ecletica-1173	185	18	,	,	PUNCT
ecletica-1173	185	19	2019	2019	NUM
ecletica-1173	185	20	;	;	PUNCT
ecletica-1173	185	21	müller	müller	PROPN
ecletica-1173	185	22	et	et	PROPN
ecletica-1173	185	23	al	al	PROPN
ecletica-1173	185	24	.	.	PROPN
ecletica-1173	185	25	,	,	PUNCT
ecletica-1173	185	26	2019	2019	NUM
ecletica-1173	185	27	)	)	PUNCT
ecletica-1173	185	28	.	.	PUNCT
ecletica-1173	186	1	however	however	ADV
ecletica-1173	186	2	,	,	PUNCT
ecletica-1173	186	3	these	these	DET
ecletica-1173	186	4	molecules	molecule	NOUN
ecletica-1173	186	5	act	act	VERB
ecletica-1173	186	6	in	in	ADP
ecletica-1173	186	7	different	different	ADJ
ecletica-1173	186	8	enzyme	enzyme	NOUN
ecletica-1173	186	9	targets	target	NOUN
ecletica-1173	186	10	.	.	PUNCT
ecletica-1173	187	1	dasatinib	dasatinib	NOUN
ecletica-1173	187	2	is	be	AUX
ecletica-1173	187	3	an	an	DET
ecletica-1173	187	4	example	example	NOUN
ecletica-1173	187	5	of	of	ADP
ecletica-1173	187	6	a	a	DET
ecletica-1173	187	7	drug	drug	NOUN
ecletica-1173	187	8	that	that	PRON
ecletica-1173	187	9	interacts	interact	VERB
ecletica-1173	187	10	with	with	ADP
ecletica-1173	187	11	several	several	ADJ
ecletica-1173	187	12	kinases	kinase	NOUN
ecletica-1173	187	13	.	.	PUNCT
ecletica-1173	188	1	dasatinib	dasatinib	NOUN
ecletica-1173	188	2	is	be	AUX
ecletica-1173	188	3	a	a	DET
ecletica-1173	188	4	targeted	target	VERB
ecletica-1173	188	5	therapy	therapy	NOUN
ecletica-1173	188	6	medication	medication	NOUN
ecletica-1173	188	7	used	use	VERB
ecletica-1173	188	8	to	to	PART
ecletica-1173	188	9	treat	treat	VERB
ecletica-1173	188	10	certain	certain	ADJ
ecletica-1173	188	11	cases	case	NOUN
ecletica-1173	188	12	of	of	ADP
ecletica-1173	188	13	chronic	chronic	ADJ
ecletica-1173	188	14	myeloid	myeloid	NOUN
ecletica-1173	188	15	leukemia	leukemia	NOUN
ecletica-1173	188	16	and	and	CCONJ
ecletica-1173	188	17	philadelphia	philadelphia	PROPN
ecletica-1173	188	18	chromosome	chromosome	NOUN
ecletica-1173	188	19	-	-	PUNCT
ecletica-1173	188	20	positive	positive	ADJ
ecletica-1173	188	21	acute	acute	ADJ
ecletica-1173	188	22	lymphoblastic	lymphoblastic	ADJ
ecletica-1173	188	23	leukemia	leukemia	NOUN
ecletica-1173	188	24	.	.	PUNCT
ecletica-1173	189	1	dasatinib	dasatinib	NOUN
ecletica-1173	189	2	is	be	AUX
ecletica-1173	189	3	a	a	DET
ecletica-1173	189	4	potent	potent	ADJ
ecletica-1173	189	5	bioavailable	bioavailable	ADJ
ecletica-1173	189	6	oral	oral	ADJ
ecletica-1173	189	7	inhibitor	inhibitor	NOUN
ecletica-1173	189	8	of	of	ADP
ecletica-1173	189	9	several	several	ADJ
ecletica-1173	189	10	kinases	kinase	NOUN
ecletica-1173	189	11	,	,	PUNCT
ecletica-1173	189	12	including	include	VERB
ecletica-1173	189	13	breakpoint	breakpoint	NOUN
ecletica-1173	189	14	cluster	cluster	NOUN
ecletica-1173	189	15	region	region	NOUN
ecletica-1173	189	16	protein	protein	NOUN
ecletica-1173	189	17	in	in	ADP
ecletica-1173	189	18	abl	abl	PROPN
ecletica-1173	189	19	genes	gene	NOUN
ecletica-1173	189	20	(	(	PUNCT
ecletica-1173	189	21	bcr	bcr	NOUN
ecletica-1173	189	22	-	-	PUNCT
ecletica-1173	189	23	abl	abl	NOUN
ecletica-1173	189	24	)	)	PUNCT
ecletica-1173	189	25	(	(	PUNCT
ecletica-1173	189	26	fig	fig	NOUN
ecletica-1173	189	27	.	.	PUNCT
ecletica-1173	190	1	2	2	NUM
ecletica-1173	190	2	)	)	PUNCT
ecletica-1173	190	3	,	,	PUNCT
ecletica-1173	190	4	protooncogene	protooncogene	NOUN
ecletica-1173	190	5	tyrosine	tyrosine	NOUN
ecletica-1173	190	6	-	-	PUNCT
ecletica-1173	190	7	protein	protein	NOUN
ecletica-1173	190	8	kinase	kinase	PROPN
ecletica-1173	190	9	src	src	PROPN
ecletica-1173	190	10	,	,	PUNCT
ecletica-1173	190	11	c	c	NOUN
ecletica-1173	190	12	-	-	PUNCT
ecletica-1173	190	13	kit	kit	NOUN
ecletica-1173	190	14	and	and	CCONJ
ecletica-1173	190	15	platelet	platelet	ADJ
ecletica-1173	190	16	-	-	PUNCT
ecletica-1173	190	17	derived	derive	VERB
ecletica-1173	190	18	growth	growth	NOUN
ecletica-1173	190	19	factor	factor	NOUN
ecletica-1173	190	20	receptor	receptor	NOUN
ecletica-1173	190	21	beta	beta	NOUN
ecletica-1173	190	22	(	(	PUNCT
ecletica-1173	190	23	pdgfrβ	pdgfrβ	NOUN
ecletica-1173	190	24	)	)	PUNCT
ecletica-1173	190	25	(	(	PUNCT
ecletica-1173	190	26	lombardo	lombardo	PROPN
ecletica-1173	190	27	et	et	PROPN
ecletica-1173	190	28	al	al	PROPN
ecletica-1173	190	29	.	.	PROPN
ecletica-1173	190	30	,	,	PUNCT
ecletica-1173	190	31	2004	2004	NUM
ecletica-1173	190	32	)	)	PUNCT
ecletica-1173	190	33	.	.	PUNCT
ecletica-1173	191	1	it	it	PRON
ecletica-1173	191	2	has	have	AUX
ecletica-1173	191	3	been	be	AUX
ecletica-1173	191	4	discovered	discover	VERB
ecletica-1173	191	5	by	by	ADP
ecletica-1173	191	6	synthesizing	synthesize	VERB
ecletica-1173	191	7	and	and	CCONJ
ecletica-1173	191	8	testing	test	VERB
ecletica-1173	191	9	a	a	DET
ecletica-1173	191	10	series	series	NOUN
ecletica-1173	191	11	of	of	ADP
ecletica-1173	191	12	thiazole	thiazole	NOUN
ecletica-1173	191	13	-	-	PUNCT
ecletica-1173	191	14	based	base	VERB
ecletica-1173	191	15	compounds	compound	NOUN
ecletica-1173	191	16	with	with	ADP
ecletica-1173	191	17	activity	activity	NOUN
ecletica-1173	191	18	against	against	ADP
ecletica-1173	191	19	src	src	NOUN
ecletica-1173	191	20	and	and	CCONJ
ecletica-1173	191	21	abl	abl	PROPN
ecletica-1173	191	22	kinases	kinase	NOUN
ecletica-1173	191	23	(	(	PUNCT
ecletica-1173	191	24	lombardo	lombardo	PROPN
ecletica-1173	191	25	et	et	PROPN
ecletica-1173	191	26	al	al	PROPN
ecletica-1173	191	27	.	.	PROPN
ecletica-1173	191	28	,	,	PUNCT
ecletica-1173	191	29	2004	2004	NUM
ecletica-1173	191	30	)	)	PUNCT
ecletica-1173	191	31	.	.	PUNCT
ecletica-1173	192	1	however	however	ADV
ecletica-1173	192	2	,	,	PUNCT
ecletica-1173	192	3	the	the	DET
ecletica-1173	192	4	dasatinib	dasatinib	NOUN
ecletica-1173	192	5	interaction	interaction	NOUN
ecletica-1173	192	6	is	be	AUX
ecletica-1173	192	7	not	not	PART
ecletica-1173	192	8	limited	limit	VERB
ecletica-1173	192	9	to	to	ADP
ecletica-1173	192	10	kinases	kinase	NOUN
ecletica-1173	192	11	.	.	PUNCT
ecletica-1173	193	1	the	the	DET
ecletica-1173	193	2	in	in	ADP
ecletica-1173	193	3	vivo	vivo	ADJ
ecletica-1173	193	4	pharmacokinetic	pharmacokinetic	ADJ
ecletica-1173	193	5	study	study	NOUN
ecletica-1173	193	6	shows	show	VERB
ecletica-1173	193	7	that	that	SCONJ
ecletica-1173	193	8	pretreatment	pretreatment	NOUN
ecletica-1173	193	9	with	with	ADP
ecletica-1173	193	10	dasatinib	dasatinib	NOUN
ecletica-1173	193	11	monohydrate	monohydrate	PROPN
ecletica-1173	193	12	decreased	decrease	VERB
ecletica-1173	193	13	the	the	DET
ecletica-1173	193	14	blood	blood	NOUN
ecletica-1173	193	15	level	level	NOUN
ecletica-1173	193	16	of	of	ADP
ecletica-1173	193	17	csa	csa	PROPN
ecletica-1173	193	18	(	(	PUNCT
ecletica-1173	193	19	cyclosporine	cyclosporine	NOUN
ecletica-1173	193	20	)	)	PUNCT
ecletica-1173	193	21	in	in	ADP
ecletica-1173	193	22	rats	rat	NOUN
ecletica-1173	193	23	,	,	PUNCT
ecletica-1173	193	24	perhaps	perhaps	ADV
ecletica-1173	193	25	due	due	ADP
ecletica-1173	193	26	to	to	ADP
ecletica-1173	193	27	induction	induction	NOUN
ecletica-1173	193	28	of	of	ADP
ecletica-1173	193	29	cytochrome	cytochrome	ADJ
ecletica-1173	193	30	p450	p450	PROPN
ecletica-1173	193	31	3a4	3a4	NUM
ecletica-1173	193	32	(	(	PUNCT
ecletica-1173	193	33	cyp3a2	cyp3a2	PROPN
ecletica-1173	193	34	)	)	PUNCT
ecletica-1173	193	35	isoenzymes	isoenzyme	NOUN
ecletica-1173	193	36	(	(	PUNCT
ecletica-1173	193	37	abdelgalil	abdelgalil	PROPN
ecletica-1173	193	38	et	et	PROPN
ecletica-1173	193	39	al	al	PROPN
ecletica-1173	193	40	.	.	PROPN
ecletica-1173	193	41	,	,	PUNCT
ecletica-1173	193	42	2019	2019	NUM
ecletica-1173	193	43	)	)	PUNCT
ecletica-1173	193	44	.	.	PUNCT
ecletica-1173	194	1	the	the	DET
ecletica-1173	194	2	cycleoxygenase	cycleoxygenase	PROPN
ecletica-1173	194	3	inhibitor	inhibitor	NOUN
ecletica-1173	194	4	aspirin	aspirin	NOUN
ecletica-1173	194	5	also	also	ADV
ecletica-1173	194	6	acts	act	VERB
ecletica-1173	194	7	on	on	ADP
ecletica-1173	194	8	different	different	ADJ
ecletica-1173	194	9	enzyme	enzyme	NOUN
ecletica-1173	194	10	targets	target	NOUN
ecletica-1173	194	11	.	.	PUNCT
ecletica-1173	195	1	aspirin	aspirin	NOUN
ecletica-1173	195	2	blocks	block	VERB
ecletica-1173	195	3	the	the	DET
ecletica-1173	195	4	formation	formation	NOUN
ecletica-1173	195	5	of	of	ADP
ecletica-1173	195	6	metastatic	metastatic	ADJ
ecletica-1173	195	7	intravascular	intravascular	ADJ
ecletica-1173	195	8	niches	niche	NOUN
ecletica-1173	195	9	by	by	ADP
ecletica-1173	195	10	inhibition	inhibition	NOUN
ecletica-1173	195	11	of	of	ADP
ecletica-1173	195	12	plateletderived	plateletderive	VERB
ecletica-1173	195	13	cox-1	cox-1	NOUN
ecletica-1173	195	14	/	/	SYM
ecletica-1173	195	15	thromboxane	thromboxane	NOUN
ecletica-1173	195	16	a2	a2	PROPN
ecletica-1173	195	17	(	(	PUNCT
ecletica-1173	195	18	ramasarma	ramasarma	PROPN
ecletica-1173	195	19	,	,	PUNCT
ecletica-1173	195	20	1994	1994	NUM
ecletica-1173	195	21	)	)	PUNCT
ecletica-1173	195	22	.	.	PUNCT
ecletica-1173	196	1	the	the	DET
ecletica-1173	196	2	intrinsic	intrinsic	ADJ
ecletica-1173	196	3	properties	property	NOUN
ecletica-1173	196	4	of	of	ADP
ecletica-1173	196	5	a	a	DET
ecletica-1173	196	6	protein	protein	NOUN
ecletica-1173	196	7	allow	allow	VERB
ecletica-1173	196	8	catalysis	catalysis	NOUN
ecletica-1173	196	9	of	of	ADP
ecletica-1173	196	10	many	many	ADJ
ecletica-1173	196	11	reactions	reaction	NOUN
ecletica-1173	196	12	.	.	PUNCT
ecletica-1173	197	1	figure	figure	NOUN
ecletica-1173	197	2	2	2	NUM
ecletica-1173	197	3	.	.	PUNCT
ecletica-1173	198	1	dasatinib	dasatinib	NOUN
ecletica-1173	198	2	interacting	interact	VERB
ecletica-1173	198	3	with	with	ADP
ecletica-1173	198	4	abl2	abl2	PROPN
ecletica-1173	198	5	/	/	SYM
ecletica-1173	198	6	arg	arg	PROPN
ecletica-1173	198	7	kinase	kinase	PROPN
ecletica-1173	198	8	.	.	PUNCT
ecletica-1173	199	1	crystal	crystal	NOUN
ecletica-1173	199	2	structure	structure	NOUN
ecletica-1173	199	3	of	of	ADP
ecletica-1173	199	4	abl2	abl2	PROPN
ecletica-1173	199	5	/	/	SYM
ecletica-1173	199	6	arg	arg	PROPN
ecletica-1173	199	7	kinase	kinase	PROPN
ecletica-1173	199	8	in	in	ADP
ecletica-1173	199	9	complex	complex	NOUN
ecletica-1173	199	10	with	with	ADP
ecletica-1173	199	11	dasatinib	dasatinib	NOUN
ecletica-1173	199	12	obtained	obtain	VERB
ecletica-1173	199	13	from	from	ADP
ecletica-1173	199	14	protein	protein	NOUN
ecletica-1173	199	15	data	data	PROPN
ecletica-1173	199	16	bank	bank	PROPN
ecletica-1173	199	17	code	code	PROPN
ecletica-1173	199	18	4xli	4xli	PROPN
ecletica-1173	199	19	.	.	PUNCT
ecletica-1173	200	1	ramasarma	ramasarma	PROPN
ecletica-1173	200	2	(	(	PUNCT
ecletica-1173	200	3	1994	1994	NUM
ecletica-1173	200	4	)	)	PUNCT
ecletica-1173	200	5	describes	describe	VERB
ecletica-1173	200	6	a	a	DET
ecletica-1173	200	7	list	list	NOUN
ecletica-1173	200	8	of	of	ADP
ecletica-1173	200	9	more	more	ADJ
ecletica-1173	200	10	than	than	ADP
ecletica-1173	200	11	fifty	fifty	NUM
ecletica-1173	200	12	proteins	protein	NOUN
ecletica-1173	200	13	with	with	ADP
ecletica-1173	200	14	the	the	DET
ecletica-1173	200	15	capacity	capacity	NOUN
ecletica-1173	200	16	to	to	PART
ecletica-1173	200	17	know	know	VERB
ecletica-1173	200	18	several	several	ADJ
ecletica-1173	200	19	kinds	kind	NOUN
ecletica-1173	200	20	of	of	ADP
ecletica-1173	200	21	molecules	molecule	NOUN
ecletica-1173	200	22	.	.	PUNCT
ecletica-1173	201	1	these	these	DET
ecletica-1173	201	2	elective	elective	ADJ
ecletica-1173	201	3	capacities	capacity	NOUN
ecletica-1173	201	4	incorporate	incorporate	VERB
ecletica-1173	201	5	a	a	DET
ecletica-1173	201	6	set	set	NOUN
ecletica-1173	201	7	of	of	ADP
ecletica-1173	201	8	activities	activity	NOUN
ecletica-1173	201	9	.	.	PUNCT
ecletica-1173	202	1	these	these	DET
ecletica-1173	202	2	biomolecules	biomolecule	NOUN
ecletica-1173	202	3	act	act	VERB
ecletica-1173	202	4	as	as	ADP
ecletica-1173	202	5	enzymes	enzyme	NOUN
ecletica-1173	202	6	,	,	PUNCT
ecletica-1173	202	7	particle	particle	NOUN
ecletica-1173	202	8	carriers	carrier	NOUN
ecletica-1173	202	9	and	and	CCONJ
ecletica-1173	202	10	inhibit	inhibit	VERB
ecletica-1173	202	11	different	different	ADJ
ecletica-1173	202	12	cellular	cellular	ADJ
ecletica-1173	202	13	processes	process	NOUN
ecletica-1173	202	14	.	.	PUNCT
ecletica-1173	203	1	it	it	PRON
ecletica-1173	203	2	was	be	AUX
ecletica-1173	203	3	discovered	discover	VERB
ecletica-1173	203	4	that	that	SCONJ
ecletica-1173	203	5	intensive	intensive	ADJ
ecletica-1173	203	6	information	information	NOUN
ecletica-1173	203	7	of	of	ADP
ecletica-1173	203	8	the	the	DET
ecletica-1173	203	9	physical	physical	ADJ
ecletica-1173	203	10	and	and	CCONJ
ecletica-1173	203	11	chemical	chemical	NOUN
ecletica-1173	203	12	properties	property	NOUN
ecletica-1173	203	13	of	of	ADP
ecletica-1173	203	14	a	a	DET
ecletica-1173	203	15	protein	protein	NOUN
ecletica-1173	203	16	will	will	AUX
ecletica-1173	203	17	not	not	PART
ecletica-1173	203	18	give	give	VERB
ecletica-1173	203	19	data	datum	NOUN
ecletica-1173	203	20	about	about	ADP
ecletica-1173	203	21	what	what	PRON
ecletica-1173	203	22	it	it	PRON
ecletica-1173	203	23	does	do	AUX
ecletica-1173	203	24	.	.	PUNCT
ecletica-1173	204	1	the	the	DET
ecletica-1173	204	2	question	question	NOUN
ecletica-1173	204	3	about	about	ADP
ecletica-1173	204	4	what	what	PRON
ecletica-1173	204	5	chemistry	chemistry	NOUN
ecletica-1173	204	6	can	can	AUX
ecletica-1173	204	7	contribute	contribute	VERB
ecletica-1173	204	8	to	to	ADP
ecletica-1173	204	9	the	the	DET
ecletica-1173	204	10	whole	whole	ADJ
ecletica-1173	204	11	biological	biological	ADJ
ecletica-1173	204	12	process	process	NOUN
ecletica-1173	204	13	is	be	AUX
ecletica-1173	204	14	not	not	PART
ecletica-1173	204	15	so	so	ADV
ecletica-1173	204	16	clear	clear	ADJ
ecletica-1173	204	17	.	.	PUNCT
ecletica-1173	205	1	reductionism	reductionism	NOUN
ecletica-1173	205	2	would	would	AUX
ecletica-1173	205	3	explain	explain	VERB
ecletica-1173	205	4	which	which	DET
ecletica-1173	205	5	proteins	protein	NOUN
ecletica-1173	205	6	produce	produce	VERB
ecletica-1173	205	7	effects	effect	NOUN
ecletica-1173	205	8	on	on	ADP
ecletica-1173	205	9	the	the	DET
ecletica-1173	205	10	biological	biological	ADJ
ecletica-1173	205	11	system	system	NOUN
ecletica-1173	205	12	.	.	PUNCT
ecletica-1173	206	1	this	this	DET
ecletica-1173	206	2	idea	idea	NOUN
ecletica-1173	206	3	was	be	AUX
ecletica-1173	206	4	created	create	VERB
ecletica-1173	206	5	by	by	ADP
ecletica-1173	206	6	pigliucci	pigliucci	PROPN
ecletica-1173	206	7	and	and	CCONJ
ecletica-1173	206	8	kaplan	kaplan	PROPN
ecletica-1173	206	9	(	(	PUNCT
ecletica-1173	206	10	2010	2010	NUM
ecletica-1173	206	11	)	)	PUNCT
ecletica-1173	206	12	.	.	PUNCT
ecletica-1173	207	1	it	it	PRON
ecletica-1173	207	2	is	be	AUX
ecletica-1173	207	3	exceptionally	exceptionally	ADV
ecletica-1173	207	4	common	common	ADJ
ecletica-1173	207	5	to	to	PART
ecletica-1173	207	6	say	say	VERB
ecletica-1173	207	7	that	that	SCONJ
ecletica-1173	207	8	a	a	DET
ecletica-1173	207	9	protein	protein	NOUN
ecletica-1173	207	10	is	be	AUX
ecletica-1173	207	11	an	an	DET
ecletica-1173	207	12	esterase	esterase	NOUN
ecletica-1173	207	13	,	,	PUNCT
ecletica-1173	207	14	kinase	kinase	PROPN
ecletica-1173	207	15	,	,	PUNCT
ecletica-1173	207	16	etc	etc	X
ecletica-1173	207	17	.	.	X
ecletica-1173	207	18	,	,	PUNCT
ecletica-1173	207	19	which	which	PRON
ecletica-1173	207	20	appears	appear	VERB
ecletica-1173	207	21	as	as	ADP
ecletica-1173	207	22	its	its	PRON
ecletica-1173	207	23	primary	primary	ADJ
ecletica-1173	207	24	function	function	NOUN
ecletica-1173	207	25	.	.	PUNCT
ecletica-1173	208	1	the	the	DET
ecletica-1173	208	2	protein	protein	NOUN
ecletica-1173	208	3	glyceraldehyde	glyceraldehyde	NOUN
ecletica-1173	208	4	3	3	NUM
ecletica-1173	208	5	-	-	PUNCT
ecletica-1173	208	6	phosphate	phosphate	NOUN
ecletica-1173	208	7	dehydrogenase	dehydrogenase	NOUN
ecletica-1173	208	8	(	(	PUNCT
ecletica-1173	208	9	gapdh	gapdh	NOUN
ecletica-1173	208	10	)	)	PUNCT
ecletica-1173	208	11	plays	play	VERB
ecletica-1173	208	12	an	an	DET
ecletica-1173	208	13	important	important	ADJ
ecletica-1173	208	14	role	role	NOUN
ecletica-1173	208	15	in	in	ADP
ecletica-1173	208	16	glyceraldehyde	glyceraldehyde	NOUN
ecletica-1173	208	17	3	3	NUM
ecletica-1173	208	18	-	-	PUNCT
ecletica-1173	208	19	phosphate	phosphate	NOUN
ecletica-1173	208	20	catalysis	catalysis	NOUN
ecletica-1173	208	21	.	.	PUNCT
ecletica-1173	209	1	glyceraldehyde	glyceraldehyde	NOUN
ecletica-1173	209	2	3	3	NUM
ecletica-1173	209	3	-	-	PUNCT
ecletica-1173	209	4	phosphate	phosphate	NOUN
ecletica-1173	209	5	dehydrogenase	dehydrogenase	NOUN
ecletica-1173	209	6	is	be	AUX
ecletica-1173	209	7	a	a	DET
ecletica-1173	209	8	bio	bio	NOUN
ecletica-1173	209	9	molecule	molecule	NOUN
ecletica-1173	209	10	with	with	ADP
ecletica-1173	209	11	a	a	DET
ecletica-1173	209	12	specific	specific	ADJ
ecletica-1173	209	13	function	function	NOUN
ecletica-1173	209	14	.	.	PUNCT
ecletica-1173	210	1	this	this	DET
ecletica-1173	210	2	enzyme	enzyme	NOUN
ecletica-1173	210	3	does	do	AUX
ecletica-1173	210	4	not	not	PART
ecletica-1173	210	5	require	require	VERB
ecletica-1173	210	6	a	a	DET
ecletica-1173	210	7	specific	specific	ADJ
ecletica-1173	210	8	molecular	molecular	ADJ
ecletica-1173	210	9	structure	structure	NOUN
ecletica-1173	210	10	,	,	PUNCT
ecletica-1173	210	11	but	but	CCONJ
ecletica-1173	210	12	an	an	DET
ecletica-1173	210	13	environment	environment	NOUN
ecletica-1173	210	14	in	in	ADP
ecletica-1173	210	15	which	which	PRON
ecletica-1173	210	16	glyceraldehyde-3	glyceraldehyde-3	NUM
ecletica-1173	210	17	-	-	ADJ
ecletica-1173	210	18	phosphate	phosphate	NOUN
ecletica-1173	210	19	is	be	AUX
ecletica-1173	210	20	changed	change	VERB
ecletica-1173	210	21	.	.	PUNCT
ecletica-1173	211	1	chemistry	chemistry	NOUN
ecletica-1173	211	2	alone	alone	ADV
ecletica-1173	211	3	can	can	AUX
ecletica-1173	211	4	not	not	PART
ecletica-1173	211	5	tell	tell	VERB
ecletica-1173	211	6	that	that	SCONJ
ecletica-1173	211	7	a	a	DET
ecletica-1173	211	8	specific	specific	ADJ
ecletica-1173	211	9	protein	protein	NOUN
ecletica-1173	211	10	is	be	AUX
ecletica-1173	211	11	gapdh	gapdh	NOUN
ecletica-1173	211	12	.	.	PUNCT
ecletica-1173	212	1	this	this	DET
ecletica-1173	212	2	bio	bio	PROPN
ecletica-1173	212	3	molecule	molecule	NOUN
ecletica-1173	212	4	will	will	AUX
ecletica-1173	212	5	only	only	ADV
ecletica-1173	212	6	perform	perform	VERB
ecletica-1173	212	7	the	the	DET
ecletica-1173	212	8	specific	specific	ADJ
ecletica-1173	212	9	activity	activity	NOUN
ecletica-1173	212	10	if	if	SCONJ
ecletica-1173	212	11	it	it	PRON
ecletica-1173	212	12	has	have	VERB
ecletica-1173	212	13	an	an	DET
ecletica-1173	212	14	environment	environment	NOUN
ecletica-1173	212	15	that	that	PRON
ecletica-1173	212	16	http://revista.iq.unesp.br/ojs/index.php/ecletica/index	http://revista.iq.unesp.br/ojs/index.php/ecletica/index	NOUN
ecletica-1173	212	17	https://doi.org/10.26850/1678-4618eqj.v46.3.2021.p17-32	https://doi.org/10.26850/1678-4618eqj.v46.3.2021.p17-32	PROPN
ecletica-1173	212	18	review	review	NOUN
ecletica-1173	212	19	article	article	NOUN
ecletica-1173	212	20	iq.unesp.br/ecletica	iq.unesp.br/ecletica	PROPN
ecletica-1173	212	21	23	23	NUM
ecletica-1173	212	22	eclética	eclética	PROPN
ecletica-1173	212	23	química	química	PROPN
ecletica-1173	212	24	journal	journal	PROPN
ecletica-1173	212	25	,	,	PUNCT
ecletica-1173	212	26	vol	vol	NOUN
ecletica-1173	212	27	.	.	PROPN
ecletica-1173	212	28	46	46	NUM
ecletica-1173	212	29	,	,	PUNCT
ecletica-1173	212	30	n.	n.	NOUN
ecletica-1173	212	31	3	3	NUM
ecletica-1173	212	32	,	,	PUNCT
ecletica-1173	212	33	2021	2021	NUM
ecletica-1173	212	34	,	,	PUNCT
ecletica-1173	212	35	17	17	NUM
ecletica-1173	212	36	-	-	SYM
ecletica-1173	212	37	32	32	NUM
ecletica-1173	212	38	issn	issn	NOUN
ecletica-1173	212	39	:	:	PUNCT
ecletica-1173	212	40	1678	1678	NUM
ecletica-1173	212	41	-	-	SYM
ecletica-1173	212	42	4618	4618	NUM
ecletica-1173	212	43	doi	doi	NOUN
ecletica-1173	212	44	:	:	PUNCT
ecletica-1173	212	45	10.26850/1678	10.26850/1678	NUM
ecletica-1173	212	46	-	-	SYM
ecletica-1173	212	47	4618eqj.v46.3.2021.p17	4618eqj.v46.3.2021.p17	NOUN
ecletica-1173	212	48	-	-	SYM
ecletica-1173	212	49	32	32	NUM
ecletica-1173	212	50	incorporates	incorporate	VERB
ecletica-1173	212	51	other	other	ADJ
ecletica-1173	212	52	components	component	NOUN
ecletica-1173	212	53	that	that	PRON
ecletica-1173	212	54	together	together	ADV
ecletica-1173	212	55	make	make	VERB
ecletica-1173	212	56	its	its	PRON
ecletica-1173	212	57	work	work	NOUN
ecletica-1173	212	58	particular	particular	ADJ
ecletica-1173	212	59	.	.	PUNCT
ecletica-1173	213	1	while	while	SCONJ
ecletica-1173	213	2	chemistry	chemistry	NOUN
ecletica-1173	213	3	concerns	concern	VERB
ecletica-1173	213	4	molecular	molecular	ADJ
ecletica-1173	213	5	structures	structure	NOUN
ecletica-1173	213	6	,	,	PUNCT
ecletica-1173	213	7	biochemistry	biochemistry	NOUN
ecletica-1173	213	8	will	will	AUX
ecletica-1173	213	9	work	work	VERB
ecletica-1173	213	10	with	with	ADP
ecletica-1173	213	11	these	these	DET
ecletica-1173	213	12	particles	particle	NOUN
ecletica-1173	213	13	inside	inside	ADP
ecletica-1173	213	14	a	a	DET
ecletica-1173	213	15	system	system	NOUN
ecletica-1173	213	16	.	.	PUNCT
ecletica-1173	214	1	the	the	DET
ecletica-1173	214	2	exclusive	exclusive	ADJ
ecletica-1173	214	3	study	study	NOUN
ecletica-1173	214	4	about	about	ADP
ecletica-1173	214	5	the	the	DET
ecletica-1173	214	6	molecule	molecule	NOUN
ecletica-1173	214	7	will	will	AUX
ecletica-1173	214	8	not	not	PART
ecletica-1173	214	9	offer	offer	VERB
ecletica-1173	214	10	a	a	DET
ecletica-1173	214	11	complete	complete	ADJ
ecletica-1173	214	12	comprehension	comprehension	NOUN
ecletica-1173	214	13	about	about	ADP
ecletica-1173	214	14	the	the	DET
ecletica-1173	214	15	function	function	NOUN
ecletica-1173	214	16	of	of	ADP
ecletica-1173	214	17	biomolecules	biomolecule	NOUN
ecletica-1173	214	18	(	(	PUNCT
ecletica-1173	214	19	alm	alm	NOUN
ecletica-1173	214	20	and	and	CCONJ
ecletica-1173	214	21	arkin	arkin	PROPN
ecletica-1173	214	22	,	,	PUNCT
ecletica-1173	214	23	2003	2003	NUM
ecletica-1173	214	24	)	)	PUNCT
ecletica-1173	214	25	.	.	PUNCT
ecletica-1173	215	1	genes	gene	NOUN
ecletica-1173	215	2	that	that	PRON
ecletica-1173	215	3	influence	influence	VERB
ecletica-1173	215	4	natural	natural	ADJ
ecletica-1173	215	5	product	product	NOUN
ecletica-1173	215	6	fly	fly	NOUN
ecletica-1173	215	7	memory	memory	NOUN
ecletica-1173	215	8	arrangement	arrangement	NOUN
ecletica-1173	215	9	encode	encode	ADJ
ecletica-1173	215	10	cyclic	cyclic	ADJ
ecletica-1173	215	11	adenosine	adenosine	NOUN
ecletica-1173	215	12	monophosphate	monophosphate	NOUN
ecletica-1173	215	13	(	(	PUNCT
ecletica-1173	215	14	camp	camp	NOUN
ecletica-1173	215	15	)	)	PUNCT
ecletica-1173	215	16	proteins	protein	NOUN
ecletica-1173	215	17	within	within	ADP
ecletica-1173	215	18	the	the	DET
ecletica-1173	215	19	signaling	signal	VERB
ecletica-1173	215	20	pathway	pathway	NOUN
ecletica-1173	215	21	are	be	AUX
ecletica-1173	215	22	not	not	PART
ecletica-1173	215	23	a	a	DET
ecletica-1173	215	24	particular	particular	ADJ
ecletica-1173	215	25	memory	memory	NOUN
ecletica-1173	215	26	.	.	PUNCT
ecletica-1173	216	1	it	it	PRON
ecletica-1173	216	2	is	be	AUX
ecletica-1173	216	3	the	the	DET
ecletica-1173	216	4	cell	cell	NOUN
ecletica-1173	216	5	compartment	compartment	NOUN
ecletica-1173	216	6	and	and	CCONJ
ecletica-1173	216	7	the	the	DET
ecletica-1173	216	8	environment	environment	NOUN
ecletica-1173	216	9	in	in	ADP
ecletica-1173	216	10	which	which	PRON
ecletica-1173	216	11	a	a	DET
ecletica-1173	216	12	camp	camp	NOUN
ecletica-1173	216	13	is	be	AUX
ecletica-1173	216	14	discharged	discharge	VERB
ecletica-1173	216	15	that	that	PRON
ecletica-1173	216	16	permits	permit	VERB
ecletica-1173	216	17	a	a	DET
ecletica-1173	216	18	hereditary	hereditary	ADJ
ecletica-1173	216	19	item	item	NOUN
ecletica-1173	216	20	to	to	PART
ecletica-1173	216	21	have	have	VERB
ecletica-1173	216	22	an	an	DET
ecletica-1173	216	23	impact	impact	NOUN
ecletica-1173	216	24	.	.	PUNCT
ecletica-1173	217	1	natural	natural	ADJ
ecletica-1173	217	2	specificity	specificity	NOUN
ecletica-1173	217	3	comes	come	VERB
ecletica-1173	217	4	from	from	ADP
ecletica-1173	217	5	the	the	DET
ecletica-1173	217	6	way	way	NOUN
ecletica-1173	217	7	that	that	PRON
ecletica-1173	217	8	these	these	DET
ecletica-1173	217	9	components	component	NOUN
ecletica-1173	217	10	gather	gather	VERB
ecletica-1173	217	11	and	and	CCONJ
ecletica-1173	217	12	work	work	VERB
ecletica-1173	217	13	together	together	ADV
ecletica-1173	217	14	.	.	PUNCT
ecletica-1173	218	1	6	6	X
ecletica-1173	218	2	.	.	X
ecletica-1173	218	3	physical	physical	ADJ
ecletica-1173	218	4	reductionism	reductionism	NOUN
ecletica-1173	218	5	the	the	DET
ecletica-1173	218	6	early	early	ADJ
ecletica-1173	218	7	twentieth	twentieth	ADJ
ecletica-1173	218	8	century	century	NOUN
ecletica-1173	218	9	had	have	VERB
ecletica-1173	218	10	a	a	DET
ecletica-1173	218	11	significant	significant	ADJ
ecletica-1173	218	12	transformation	transformation	NOUN
ecletica-1173	218	13	in	in	ADP
ecletica-1173	218	14	the	the	DET
ecletica-1173	218	15	context	context	NOUN
ecletica-1173	218	16	of	of	ADP
ecletica-1173	218	17	atomic	atomic	ADJ
ecletica-1173	218	18	structure	structure	NOUN
ecletica-1173	218	19	.	.	PUNCT
ecletica-1173	219	1	the	the	DET
ecletica-1173	219	2	old	old	ADJ
ecletica-1173	219	3	greeks	greeks	PROPN
ecletica-1173	219	4	tried	try	VERB
ecletica-1173	219	5	to	to	PART
ecletica-1173	219	6	explain	explain	VERB
ecletica-1173	219	7	the	the	DET
ecletica-1173	219	8	existence	existence	NOUN
ecletica-1173	219	9	of	of	ADP
ecletica-1173	219	10	atoms	atom	NOUN
ecletica-1173	219	11	from	from	ADP
ecletica-1173	219	12	philosophical	philosophical	ADJ
ecletica-1173	219	13	central	central	ADJ
ecletica-1173	219	14	conjectures	conjecture	NOUN
ecletica-1173	219	15	.	.	PUNCT
ecletica-1173	220	1	dalton	dalton	PROPN
ecletica-1173	220	2	later	later	ADV
ecletica-1173	220	3	differentiated	differentiate	VERB
ecletica-1173	220	4	atoms	atom	NOUN
ecletica-1173	220	5	with	with	ADP
ecletica-1173	220	6	the	the	DET
ecletica-1173	220	7	help	help	NOUN
ecletica-1173	220	8	of	of	ADP
ecletica-1173	220	9	the	the	DET
ecletica-1173	220	10	balance	balance	NOUN
ecletica-1173	220	11	.	.	PUNCT
ecletica-1173	221	1	however	however	ADV
ecletica-1173	221	2	,	,	PUNCT
ecletica-1173	221	3	the	the	DET
ecletica-1173	221	4	atoms	atom	NOUN
ecletica-1173	221	5	remained	remain	VERB
ecletica-1173	221	6	nondivisible	nondivisible	ADJ
ecletica-1173	221	7	,	,	PUNCT
ecletica-1173	221	8	as	as	ADP
ecletica-1173	221	9	that	that	PRON
ecletica-1173	221	10	of	of	ADP
ecletica-1173	221	11	the	the	DET
ecletica-1173	221	12	greeks	greeks	PROPN
ecletica-1173	221	13	(	(	PUNCT
ecletica-1173	221	14	democritus	democritus	PROPN
ecletica-1173	221	15	and	and	CCONJ
ecletica-1173	221	16	leucippus	leucippus	PROPN
ecletica-1173	221	17	)	)	PUNCT
ecletica-1173	221	18	.	.	PUNCT
ecletica-1173	222	1	thomson	thomson	PROPN
ecletica-1173	222	2	used	use	VERB
ecletica-1173	222	3	the	the	DET
ecletica-1173	222	4	cathode	cathode	NOUN
ecletica-1173	222	5	ray	ray	NOUN
ecletica-1173	222	6	tube	tube	NOUN
ecletica-1173	222	7	to	to	PART
ecletica-1173	222	8	discover	discover	VERB
ecletica-1173	222	9	electrons	electron	NOUN
ecletica-1173	222	10	.	.	PUNCT
ecletica-1173	223	1	rutherford	rutherford	PROPN
ecletica-1173	223	2	bombardments	bombardment	VERB
ecletica-1173	223	3	a	a	DET
ecletica-1173	223	4	gold	gold	NOUN
ecletica-1173	223	5	plate	plate	NOUN
ecletica-1173	223	6	to	to	PART
ecletica-1173	223	7	discover	discover	VERB
ecletica-1173	223	8	the	the	DET
ecletica-1173	223	9	existence	existence	NOUN
ecletica-1173	223	10	of	of	ADP
ecletica-1173	223	11	the	the	DET
ecletica-1173	223	12	nucleus	nucleus	NOUN
ecletica-1173	223	13	.	.	PUNCT
ecletica-1173	224	1	planck	planck	NOUN
ecletica-1173	224	2	begins	begin	VERB
ecletica-1173	224	3	quantum	quantum	ADJ
ecletica-1173	224	4	mechanics	mechanic	NOUN
ecletica-1173	224	5	studying	study	VERB
ecletica-1173	224	6	the	the	DET
ecletica-1173	224	7	heat	heat	NOUN
ecletica-1173	224	8	from	from	ADP
ecletica-1173	224	9	materials	material	NOUN
ecletica-1173	224	10	at	at	ADP
ecletica-1173	224	11	high	high	ADJ
ecletica-1173	224	12	temperatures	temperature	NOUN
ecletica-1173	224	13	.	.	PUNCT
ecletica-1173	225	1	einstein	einstein	PROPN
ecletica-1173	225	2	theorizes	theorize	VERB
ecletica-1173	225	3	the	the	DET
ecletica-1173	225	4	corpuscular	corpuscular	ADJ
ecletica-1173	225	5	nature	nature	NOUN
ecletica-1173	225	6	using	use	VERB
ecletica-1173	225	7	the	the	DET
ecletica-1173	225	8	photoelectric	photoelectric	ADJ
ecletica-1173	225	9	effect	effect	NOUN
ecletica-1173	225	10	.	.	PUNCT
ecletica-1173	226	1	schrödinger	schrödinger	ADJ
ecletica-1173	226	2	(	(	PUNCT
ecletica-1173	226	3	1926	1926	NUM
ecletica-1173	226	4	)	)	PUNCT
ecletica-1173	226	5	developed	develop	VERB
ecletica-1173	226	6	a	a	DET
ecletica-1173	226	7	wave	wave	NOUN
ecletica-1173	226	8	equation	equation	NOUN
ecletica-1173	226	9	whose	whose	DET
ecletica-1173	226	10	solutions	solution	NOUN
ecletica-1173	226	11	are	be	AUX
ecletica-1173	226	12	the	the	DET
ecletica-1173	226	13	quantum	quantum	ADJ
ecletica-1173	226	14	numbers	number	NOUN
ecletica-1173	226	15	.	.	PUNCT
ecletica-1173	227	1	at	at	ADP
ecletica-1173	227	2	this	this	DET
ecletica-1173	227	3	point	point	NOUN
ecletica-1173	227	4	,	,	PUNCT
ecletica-1173	227	5	the	the	DET
ecletica-1173	227	6	reductionism	reductionism	NOUN
ecletica-1173	227	7	of	of	ADP
ecletica-1173	227	8	chemistry	chemistry	NOUN
ecletica-1173	227	9	to	to	ADP
ecletica-1173	227	10	physics	physics	NOUN
ecletica-1173	227	11	began	begin	VERB
ecletica-1173	227	12	,	,	PUNCT
ecletica-1173	227	13	as	as	SCONJ
ecletica-1173	227	14	dirac	dirac	NOUN
ecletica-1173	227	15	(	(	PUNCT
ecletica-1173	227	16	1929	1929	NUM
ecletica-1173	227	17	)	)	PUNCT
ecletica-1173	227	18	points	point	VERB
ecletica-1173	227	19	out	out	ADP
ecletica-1173	227	20	:	:	PUNCT
ecletica-1173	227	21	“	"	PUNCT
ecletica-1173	227	22	the	the	DET
ecletica-1173	227	23	general	general	ADJ
ecletica-1173	227	24	theory	theory	NOUN
ecletica-1173	227	25	of	of	ADP
ecletica-1173	227	26	quantum	quantum	ADJ
ecletica-1173	227	27	mechanics	mechanic	NOUN
ecletica-1173	227	28	is	be	AUX
ecletica-1173	227	29	now	now	ADV
ecletica-1173	227	30	almost	almost	ADV
ecletica-1173	227	31	complete	complete	ADJ
ecletica-1173	227	32	,	,	PUNCT
ecletica-1173	227	33	the	the	DET
ecletica-1173	227	34	imperfections	imperfection	NOUN
ecletica-1173	227	35	that	that	PRON
ecletica-1173	227	36	still	still	ADV
ecletica-1173	227	37	remain	remain	VERB
ecletica-1173	227	38	being	be	AUX
ecletica-1173	227	39	in	in	ADP
ecletica-1173	227	40	connection	connection	NOUN
ecletica-1173	227	41	with	with	ADP
ecletica-1173	227	42	the	the	DET
ecletica-1173	227	43	exact	exact	NOUN
ecletica-1173	227	44	fitting	fitting	ADJ
ecletica-1173	227	45	in	in	ADP
ecletica-1173	227	46	of	of	ADP
ecletica-1173	227	47	the	the	DET
ecletica-1173	227	48	theory	theory	NOUN
ecletica-1173	227	49	with	with	ADP
ecletica-1173	227	50	relativity	relativity	NOUN
ecletica-1173	227	51	ideas	idea	NOUN
ecletica-1173	227	52	.	.	PUNCT
ecletica-1173	228	1	these	these	PRON
ecletica-1173	228	2	give	give	VERB
ecletica-1173	228	3	rise	rise	NOUN
ecletica-1173	228	4	to	to	ADP
ecletica-1173	228	5	difficulties	difficulty	NOUN
ecletica-1173	228	6	only	only	ADV
ecletica-1173	228	7	when	when	SCONJ
ecletica-1173	228	8	high	high	ADJ
ecletica-1173	228	9	-	-	PUNCT
ecletica-1173	228	10	speed	speed	NOUN
ecletica-1173	228	11	particles	particle	NOUN
ecletica-1173	228	12	are	be	AUX
ecletica-1173	228	13	involved	involve	VERB
ecletica-1173	228	14	,	,	PUNCT
ecletica-1173	228	15	and	and	CCONJ
ecletica-1173	228	16	are	be	AUX
ecletica-1173	228	17	therefore	therefore	ADV
ecletica-1173	228	18	of	of	ADP
ecletica-1173	228	19	no	no	DET
ecletica-1173	228	20	importance	importance	NOUN
ecletica-1173	228	21	in	in	ADP
ecletica-1173	228	22	the	the	DET
ecletica-1173	228	23	consideration	consideration	NOUN
ecletica-1173	228	24	of	of	ADP
ecletica-1173	228	25	atomic	atomic	ADJ
ecletica-1173	228	26	and	and	CCONJ
ecletica-1173	228	27	molecular	molecular	ADJ
ecletica-1173	228	28	structure	structure	NOUN
ecletica-1173	228	29	and	and	CCONJ
ecletica-1173	228	30	ordinary	ordinary	ADJ
ecletica-1173	228	31	chemical	chemical	NOUN
ecletica-1173	228	32	reactions	reaction	NOUN
ecletica-1173	228	33	,	,	PUNCT
ecletica-1173	228	34	in	in	ADP
ecletica-1173	228	35	which	which	PRON
ecletica-1173	228	36	it	it	PRON
ecletica-1173	228	37	is	be	AUX
ecletica-1173	228	38	,	,	PUNCT
ecletica-1173	228	39	indeed	indeed	ADV
ecletica-1173	228	40	,	,	PUNCT
ecletica-1173	228	41	usually	usually	ADV
ecletica-1173	228	42	sufficiently	sufficiently	ADV
ecletica-1173	228	43	accurate	accurate	ADJ
ecletica-1173	228	44	if	if	SCONJ
ecletica-1173	228	45	one	one	NUM
ecletica-1173	228	46	neglects	neglect	VERB
ecletica-1173	228	47	relativity	relativity	NOUN
ecletica-1173	228	48	variation	variation	NOUN
ecletica-1173	228	49	of	of	ADP
ecletica-1173	228	50	mass	mass	NOUN
ecletica-1173	228	51	with	with	ADP
ecletica-1173	228	52	velocity	velocity	NOUN
ecletica-1173	228	53	and	and	CCONJ
ecletica-1173	228	54	assumes	assume	VERB
ecletica-1173	228	55	only	only	ADV
ecletica-1173	228	56	coulomb	coulomb	NOUN
ecletica-1173	228	57	forces	force	NOUN
ecletica-1173	228	58	between	between	ADP
ecletica-1173	228	59	the	the	DET
ecletica-1173	228	60	various	various	ADJ
ecletica-1173	228	61	electrons	electron	NOUN
ecletica-1173	228	62	and	and	CCONJ
ecletica-1173	228	63	atomic	atomic	ADJ
ecletica-1173	228	64	nuclei	nucleus	NOUN
ecletica-1173	228	65	.	.	PUNCT
ecletica-1173	229	1	the	the	DET
ecletica-1173	229	2	underlying	underlying	ADJ
ecletica-1173	229	3	physical	physical	ADJ
ecletica-1173	229	4	laws	law	NOUN
ecletica-1173	229	5	necessary	necessary	ADJ
ecletica-1173	229	6	for	for	ADP
ecletica-1173	229	7	the	the	DET
ecletica-1173	229	8	mathematical	mathematical	ADJ
ecletica-1173	229	9	theory	theory	NOUN
ecletica-1173	229	10	of	of	ADP
ecletica-1173	229	11	a	a	DET
ecletica-1173	229	12	large	large	ADJ
ecletica-1173	229	13	part	part	NOUN
ecletica-1173	229	14	of	of	ADP
ecletica-1173	229	15	physics	physics	NOUN
ecletica-1173	229	16	and	and	CCONJ
ecletica-1173	229	17	the	the	DET
ecletica-1173	229	18	whole	whole	NOUN
ecletica-1173	229	19	of	of	ADP
ecletica-1173	229	20	chemistry	chemistry	NOUN
ecletica-1173	229	21	are	be	AUX
ecletica-1173	229	22	thus	thus	ADV
ecletica-1173	229	23	completely	completely	ADV
ecletica-1173	229	24	known	know	VERB
ecletica-1173	229	25	,	,	PUNCT
ecletica-1173	229	26	and	and	CCONJ
ecletica-1173	229	27	the	the	DET
ecletica-1173	229	28	difficulty	difficulty	NOUN
ecletica-1173	229	29	is	be	AUX
ecletica-1173	229	30	only	only	ADV
ecletica-1173	229	31	that	that	SCONJ
ecletica-1173	229	32	the	the	DET
ecletica-1173	229	33	exact	exact	ADJ
ecletica-1173	229	34	application	application	NOUN
ecletica-1173	229	35	of	of	ADP
ecletica-1173	229	36	these	these	DET
ecletica-1173	229	37	laws	law	NOUN
ecletica-1173	229	38	leads	lead	VERB
ecletica-1173	229	39	to	to	ADP
ecletica-1173	229	40	equations	equation	NOUN
ecletica-1173	229	41	much	much	ADV
ecletica-1173	229	42	too	too	ADV
ecletica-1173	229	43	complicated	complicated	ADJ
ecletica-1173	229	44	to	to	PART
ecletica-1173	229	45	be	be	AUX
ecletica-1173	229	46	soluble	soluble	ADJ
ecletica-1173	229	47	.	.	PUNCT
ecletica-1173	229	48	”	"	PUNCT
ecletica-1173	230	1	this	this	PRON
ecletica-1173	230	2	is	be	AUX
ecletica-1173	230	3	a	a	DET
ecletica-1173	230	4	clear	clear	ADJ
ecletica-1173	230	5	epistemological	epistemological	ADJ
ecletica-1173	230	6	reductionism	reductionism	NOUN
ecletica-1173	230	7	defended	defend	VERB
ecletica-1173	230	8	by	by	ADP
ecletica-1173	230	9	dirac	dirac	NOUN
ecletica-1173	230	10	.	.	PUNCT
ecletica-1173	231	1	it	it	PRON
ecletica-1173	231	2	is	be	AUX
ecletica-1173	231	3	not	not	PART
ecletica-1173	231	4	only	only	ADV
ecletica-1173	231	5	a	a	DET
ecletica-1173	231	6	methodological	methodological	ADJ
ecletica-1173	231	7	approach	approach	NOUN
ecletica-1173	231	8	,	,	PUNCT
ecletica-1173	231	9	but	but	CCONJ
ecletica-1173	231	10	a	a	DET
ecletica-1173	231	11	complete	complete	ADJ
ecletica-1173	231	12	explanation	explanation	NOUN
ecletica-1173	231	13	of	of	ADP
ecletica-1173	231	14	chemistry	chemistry	NOUN
ecletica-1173	231	15	using	use	VERB
ecletica-1173	231	16	the	the	DET
ecletica-1173	231	17	quantum	quantum	ADJ
ecletica-1173	231	18	mechanics	mechanic	NOUN
ecletica-1173	231	19	equations	equation	NOUN
ecletica-1173	231	20	.	.	PUNCT
ecletica-1173	232	1	however	however	ADV
ecletica-1173	232	2	,	,	PUNCT
ecletica-1173	232	3	it	it	PRON
ecletica-1173	232	4	will	will	AUX
ecletica-1173	232	5	be	be	AUX
ecletica-1173	232	6	shown	show	VERB
ecletica-1173	232	7	that	that	SCONJ
ecletica-1173	232	8	the	the	DET
ecletica-1173	232	9	presumptions	presumption	NOUN
ecletica-1173	232	10	made	make	VERB
ecletica-1173	232	11	by	by	ADP
ecletica-1173	232	12	dirac	dirac	NOUN
ecletica-1173	232	13	are	be	AUX
ecletica-1173	232	14	not	not	PART
ecletica-1173	232	15	entirely	entirely	ADV
ecletica-1173	232	16	correct	correct	ADJ
ecletica-1173	232	17	.	.	PUNCT
ecletica-1173	233	1	although	although	SCONJ
ecletica-1173	233	2	a	a	DET
ecletica-1173	233	3	methodological	methodological	ADJ
ecletica-1173	233	4	reductionism	reductionism	NOUN
ecletica-1173	233	5	can	can	AUX
ecletica-1173	233	6	be	be	AUX
ecletica-1173	233	7	used	use	VERB
ecletica-1173	233	8	to	to	PART
ecletica-1173	233	9	simulate	simulate	VERB
ecletica-1173	233	10	the	the	DET
ecletica-1173	233	11	atoms	atom	NOUN
ecletica-1173	233	12	and	and	CCONJ
ecletica-1173	233	13	molecules	molecule	NOUN
ecletica-1173	233	14	.	.	PUNCT
ecletica-1173	234	1	physical	physical	ADJ
ecletica-1173	234	2	-	-	PUNCT
ecletica-1173	234	3	level	level	NOUN
ecletica-1173	234	4	reductionism	reductionism	NOUN
ecletica-1173	234	5	is	be	AUX
ecletica-1173	234	6	visible	visible	ADJ
ecletica-1173	234	7	in	in	ADP
ecletica-1173	234	8	biomolecule	biomolecule	NOUN
ecletica-1173	234	9	modeling	modeling	NOUN
ecletica-1173	234	10	for	for	ADP
ecletica-1173	234	11	new	new	ADJ
ecletica-1173	234	12	drug	drug	NOUN
ecletica-1173	234	13	planning	planning	NOUN
ecletica-1173	234	14	purposes	purpose	NOUN
ecletica-1173	234	15	.	.	PUNCT
ecletica-1173	235	1	the	the	DET
ecletica-1173	235	2	behavior	behavior	NOUN
ecletica-1173	235	3	of	of	ADP
ecletica-1173	235	4	biological	biological	ADJ
ecletica-1173	235	5	molecules	molecule	NOUN
ecletica-1173	235	6	is	be	AUX
ecletica-1173	235	7	studied	study	VERB
ecletica-1173	235	8	from	from	ADP
ecletica-1173	235	9	quantum	quantum	ADJ
ecletica-1173	235	10	approaches	approach	NOUN
ecletica-1173	235	11	,	,	PUNCT
ecletica-1173	235	12	semi	semi	ADJ
ecletica-1173	235	13	-	-	ADJ
ecletica-1173	235	14	empirical	empirical	ADJ
ecletica-1173	235	15	and	and	CCONJ
ecletica-1173	235	16	classical	classical	ADJ
ecletica-1173	235	17	models	model	NOUN
ecletica-1173	235	18	.	.	PUNCT
ecletica-1173	236	1	in	in	ADP
ecletica-1173	236	2	this	this	DET
ecletica-1173	236	3	case	case	NOUN
ecletica-1173	236	4	,	,	PUNCT
ecletica-1173	236	5	the	the	DET
ecletica-1173	236	6	molecules	molecule	NOUN
ecletica-1173	236	7	and	and	CCONJ
ecletica-1173	236	8	their	their	PRON
ecletica-1173	236	9	properties	property	NOUN
ecletica-1173	236	10	are	be	AUX
ecletica-1173	236	11	explained	explain	VERB
ecletica-1173	236	12	by	by	ADP
ecletica-1173	236	13	quantum	quantum	ADJ
ecletica-1173	236	14	mechanics	mechanic	NOUN
ecletica-1173	236	15	and	and	CCONJ
ecletica-1173	236	16	their	their	PRON
ecletica-1173	236	17	approximations	approximation	NOUN
ecletica-1173	236	18	.	.	PUNCT
ecletica-1173	237	1	in	in	ADP
ecletica-1173	237	2	general	general	ADJ
ecletica-1173	237	3	,	,	PUNCT
ecletica-1173	237	4	the	the	DET
ecletica-1173	237	5	coordinates	coordinate	NOUN
ecletica-1173	237	6	of	of	ADP
ecletica-1173	237	7	atoms	atom	NOUN
ecletica-1173	237	8	are	be	AUX
ecletica-1173	237	9	given	give	VERB
ecletica-1173	237	10	.	.	PUNCT
ecletica-1173	238	1	from	from	ADP
ecletica-1173	238	2	these	these	DET
ecletica-1173	238	3	coordinates	coordinate	NOUN
ecletica-1173	238	4	,	,	PUNCT
ecletica-1173	238	5	atomic	atomic	ADJ
ecletica-1173	238	6	number	number	NOUN
ecletica-1173	238	7	,	,	PUNCT
ecletica-1173	238	8	mass	mass	PROPN
ecletica-1173	238	9	,	,	PUNCT
ecletica-1173	238	10	among	among	ADP
ecletica-1173	238	11	other	other	ADJ
ecletica-1173	238	12	properties	property	NOUN
ecletica-1173	238	13	,	,	PUNCT
ecletica-1173	238	14	are	be	AUX
ecletica-1173	238	15	extracted	extract	VERB
ecletica-1173	238	16	chemical	chemical	ADJ
ecletica-1173	238	17	and	and	CCONJ
ecletica-1173	238	18	biological	biological	ADJ
ecletica-1173	238	19	properties	property	NOUN
ecletica-1173	238	20	of	of	ADP
ecletica-1173	238	21	interest	interest	NOUN
ecletica-1173	238	22	.	.	PUNCT
ecletica-1173	239	1	the	the	DET
ecletica-1173	239	2	heart	heart	NOUN
ecletica-1173	239	3	of	of	ADP
ecletica-1173	239	4	quantum	quantum	NOUN
ecletica-1173	239	5	theory	theory	NOUN
ecletica-1173	239	6	for	for	ADP
ecletica-1173	239	7	atoms	atom	NOUN
ecletica-1173	239	8	and	and	CCONJ
ecletica-1173	239	9	molecules	molecule	NOUN
ecletica-1173	239	10	is	be	AUX
ecletica-1173	239	11	the	the	DET
ecletica-1173	239	12	resolution	resolution	NOUN
ecletica-1173	239	13	of	of	ADP
ecletica-1173	239	14	the	the	DET
ecletica-1173	239	15	schrodinger	schrodinger	PROPN
ecletica-1173	239	16	equation	equation	NOUN
ecletica-1173	239	17	.	.	PUNCT
ecletica-1173	240	1	however	however	ADV
ecletica-1173	240	2	,	,	PUNCT
ecletica-1173	240	3	this	this	DET
ecletica-1173	240	4	equation	equation	NOUN
ecletica-1173	240	5	has	have	VERB
ecletica-1173	240	6	no	no	DET
ecletica-1173	240	7	analytical	analytical	ADJ
ecletica-1173	240	8	solution	solution	NOUN
ecletica-1173	240	9	for	for	ADP
ecletica-1173	240	10	atoms	atom	NOUN
ecletica-1173	240	11	with	with	ADP
ecletica-1173	240	12	more	more	ADJ
ecletica-1173	240	13	than	than	ADP
ecletica-1173	240	14	one	one	NUM
ecletica-1173	240	15	electron	electron	NOUN
ecletica-1173	240	16	.	.	PUNCT
ecletica-1173	241	1	approaches	approach	NOUN
ecletica-1173	241	2	are	be	AUX
ecletica-1173	241	3	required	require	VERB
ecletica-1173	241	4	to	to	PART
ecletica-1173	241	5	solve	solve	VERB
ecletica-1173	241	6	this	this	DET
ecletica-1173	241	7	problem	problem	NOUN
ecletica-1173	241	8	.	.	PUNCT
ecletica-1173	242	1	one	one	NUM
ecletica-1173	242	2	of	of	ADP
ecletica-1173	242	3	the	the	DET
ecletica-1173	242	4	first	first	ADJ
ecletica-1173	242	5	approximations	approximation	NOUN
ecletica-1173	242	6	to	to	PART
ecletica-1173	242	7	facilitate	facilitate	VERB
ecletica-1173	242	8	the	the	DET
ecletica-1173	242	9	resolution	resolution	NOUN
ecletica-1173	242	10	of	of	ADP
ecletica-1173	242	11	the	the	DET
ecletica-1173	242	12	schrödinger	schrödinger	ADJ
ecletica-1173	242	13	equation	equation	NOUN
ecletica-1173	242	14	is	be	AUX
ecletica-1173	242	15	the	the	DET
ecletica-1173	242	16	born	bear	VERB
ecletica-1173	242	17	–	–	PUNCT
ecletica-1173	242	18	oppenheimer	oppenheimer	PROPN
ecletica-1173	242	19	approximation	approximation	NOUN
ecletica-1173	242	20	.	.	PUNCT
ecletica-1173	243	1	in	in	ADP
ecletica-1173	243	2	this	this	DET
ecletica-1173	243	3	approach	approach	NOUN
ecletica-1173	243	4	,	,	PUNCT
ecletica-1173	243	5	it	it	PRON
ecletica-1173	243	6	is	be	AUX
ecletica-1173	243	7	assumed	assume	VERB
ecletica-1173	243	8	that	that	SCONJ
ecletica-1173	243	9	the	the	DET
ecletica-1173	243	10	motion	motion	NOUN
ecletica-1173	243	11	of	of	ADP
ecletica-1173	243	12	the	the	DET
ecletica-1173	243	13	atomic	atomic	ADJ
ecletica-1173	243	14	nucleus	nucleus	NOUN
ecletica-1173	243	15	and	and	CCONJ
ecletica-1173	243	16	electrons	electron	NOUN
ecletica-1173	243	17	can	can	AUX
ecletica-1173	243	18	be	be	AUX
ecletica-1173	243	19	separated	separate	VERB
ecletica-1173	243	20	(	(	PUNCT
ecletica-1173	243	21	born	bear	VERB
ecletica-1173	243	22	and	and	CCONJ
ecletica-1173	243	23	oppenheimer	oppenheimer	PROPN
ecletica-1173	243	24	,	,	PUNCT
ecletica-1173	243	25	1927	1927	NUM
ecletica-1173	243	26	)	)	PUNCT
ecletica-1173	243	27	.	.	PUNCT
ecletica-1173	244	1	chemical	chemical	NOUN
ecletica-1173	244	2	structure	structure	NOUN
ecletica-1173	244	3	can	can	AUX
ecletica-1173	244	4	not	not	PART
ecletica-1173	244	5	be	be	AUX
ecletica-1173	244	6	found	find	VERB
ecletica-1173	244	7	in	in	ADP
ecletica-1173	244	8	pure	pure	ADJ
ecletica-1173	244	9	quantum	quantum	ADJ
ecletica-1173	244	10	mechanics	mechanic	NOUN
ecletica-1173	244	11	applied	apply	VERB
ecletica-1173	244	12	to	to	ADP
ecletica-1173	244	13	a	a	DET
ecletica-1173	244	14	chemical	chemical	NOUN
ecletica-1173	244	15	system	system	NOUN
ecletica-1173	244	16	.	.	PUNCT
ecletica-1173	245	1	it	it	PRON
ecletica-1173	245	2	is	be	AUX
ecletica-1173	245	3	imposed	impose	VERB
ecletica-1173	245	4	by	by	ADP
ecletica-1173	245	5	the	the	DET
ecletica-1173	245	6	born	bear	VERB
ecletica-1173	245	7	–	–	PUNCT
ecletica-1173	245	8	oppenheimer	oppenheimer	PROPN
ecletica-1173	245	9	approach	approach	NOUN
ecletica-1173	245	10	(	(	PUNCT
ecletica-1173	245	11	woolley	woolley	PROPN
ecletica-1173	245	12	,	,	PUNCT
ecletica-1173	245	13	1978	1978	NUM
ecletica-1173	245	14	)	)	PUNCT
ecletica-1173	245	15	.	.	PUNCT
ecletica-1173	246	1	new	new	ADJ
ecletica-1173	246	2	approaches	approach	NOUN
ecletica-1173	246	3	were	be	AUX
ecletica-1173	246	4	developed	develop	VERB
ecletica-1173	246	5	to	to	PART
ecletica-1173	246	6	explain	explain	VERB
ecletica-1173	246	7	the	the	DET
ecletica-1173	246	8	chemical	chemical	NOUN
ecletica-1173	246	9	bond	bond	NOUN
ecletica-1173	246	10	originating	originate	VERB
ecletica-1173	246	11	quantum	quantum	ADJ
ecletica-1173	246	12	chemistry	chemistry	NOUN
ecletica-1173	246	13	methodologies	methodologie	VERB
ecletica-1173	246	14	the	the	DET
ecletica-1173	246	15	introduction	introduction	NOUN
ecletica-1173	246	16	of	of	ADP
ecletica-1173	246	17	the	the	DET
ecletica-1173	246	18	electron	electron	NOUN
ecletica-1173	246	19	spin	spin	NOUN
ecletica-1173	246	20	and	and	CCONJ
ecletica-1173	246	21	the	the	DET
ecletica-1173	246	22	pauli	pauli	PROPN
ecletica-1173	246	23	exclusion	exclusion	NOUN
ecletica-1173	246	24	principle	principle	NOUN
ecletica-1173	246	25	were	be	AUX
ecletica-1173	246	26	used	use	VERB
ecletica-1173	246	27	to	to	PART
ecletica-1173	246	28	explain	explain	VERB
ecletica-1173	246	29	the	the	DET
ecletica-1173	246	30	formation	formation	NOUN
ecletica-1173	246	31	of	of	ADP
ecletica-1173	246	32	a	a	DET
ecletica-1173	246	33	chemical	chemical	NOUN
ecletica-1173	246	34	bond	bond	NOUN
ecletica-1173	246	35	.	.	PUNCT
ecletica-1173	247	1	the	the	DET
ecletica-1173	247	2	linear	linear	ADJ
ecletica-1173	247	3	combination	combination	NOUN
ecletica-1173	247	4	of	of	ADP
ecletica-1173	247	5	atomic	atomic	ADJ
ecletica-1173	247	6	orbitals	orbital	NOUN
ecletica-1173	247	7	(	(	PUNCT
ecletica-1173	247	8	lcao	lcao	NOUN
ecletica-1173	247	9	)	)	PUNCT
ecletica-1173	247	10	and	and	CCONJ
ecletica-1173	247	11	valency	valency	NOUN
ecletica-1173	247	12	theory	theory	NOUN
ecletica-1173	247	13	were	be	AUX
ecletica-1173	247	14	used	use	VERB
ecletica-1173	247	15	to	to	PART
ecletica-1173	247	16	describe	describe	VERB
ecletica-1173	247	17	the	the	DET
ecletica-1173	247	18	chemical	chemical	NOUN
ecletica-1173	247	19	bond	bond	NOUN
ecletica-1173	247	20	.	.	PUNCT
ecletica-1173	248	1	however	however	ADV
ecletica-1173	248	2	,	,	PUNCT
ecletica-1173	248	3	there	there	PRON
ecletica-1173	248	4	is	be	VERB
ecletica-1173	248	5	the	the	DET
ecletica-1173	248	6	problem	problem	NOUN
ecletica-1173	248	7	associated	associate	VERB
ecletica-1173	248	8	with	with	ADP
ecletica-1173	248	9	the	the	DET
ecletica-1173	248	10	schrodinger	schrodinger	PROPN
ecletica-1173	248	11	equation	equation	NOUN
ecletica-1173	248	12	solution	solution	NOUN
ecletica-1173	248	13	to	to	ADP
ecletica-1173	248	14	many	many	ADJ
ecletica-1173	248	15	electrons	electron	NOUN
ecletica-1173	248	16	.	.	PUNCT
ecletica-1173	249	1	several	several	ADJ
ecletica-1173	249	2	approaches	approach	NOUN
ecletica-1173	249	3	were	be	AUX
ecletica-1173	249	4	used	use	VERB
ecletica-1173	249	5	to	to	PART
ecletica-1173	249	6	solve	solve	VERB
ecletica-1173	249	7	this	this	DET
ecletica-1173	249	8	limitation	limitation	NOUN
ecletica-1173	249	9	.	.	PUNCT
ecletica-1173	250	1	the	the	DET
ecletica-1173	250	2	first	first	ADJ
ecletica-1173	250	3	,	,	PUNCT
ecletica-1173	250	4	already	already	ADV
ecletica-1173	250	5	presented	present	VERB
ecletica-1173	250	6	,	,	PUNCT
ecletica-1173	250	7	is	be	AUX
ecletica-1173	250	8	that	that	PRON
ecletica-1173	250	9	of	of	ADP
ecletica-1173	250	10	born	bear	VERB
ecletica-1173	250	11	–	–	PUNCT
ecletica-1173	250	12	oppenheimer	oppenheimer	PROPN
ecletica-1173	250	13	.	.	PUNCT
ecletica-1173	251	1	the	the	DET
ecletica-1173	251	2	other	other	ADJ
ecletica-1173	251	3	approximations	approximation	NOUN
ecletica-1173	251	4	are	be	AUX
ecletica-1173	251	5	dependent	dependent	ADJ
ecletica-1173	251	6	on	on	ADP
ecletica-1173	251	7	the	the	DET
ecletica-1173	251	8	method	method	NOUN
ecletica-1173	251	9	used	use	VERB
ecletica-1173	251	10	.	.	PUNCT
ecletica-1173	252	1	it	it	PRON
ecletica-1173	252	2	is	be	AUX
ecletica-1173	252	3	important	important	ADJ
ecletica-1173	252	4	to	to	PART
ecletica-1173	252	5	note	note	VERB
ecletica-1173	252	6	that	that	SCONJ
ecletica-1173	252	7	neither	neither	DET
ecletica-1173	252	8	approach	approach	NOUN
ecletica-1173	252	9	solves	solve	VERB
ecletica-1173	252	10	the	the	DET
ecletica-1173	252	11	schrödinger	schrödinger	ADJ
ecletica-1173	252	12	equation	equation	NOUN
ecletica-1173	252	13	analytically	analytically	ADV
ecletica-1173	252	14	.	.	PUNCT
ecletica-1173	253	1	hartree	hartree	PROPN
ecletica-1173	253	2	’s	’s	PROPN
ecletica-1173	253	3	(	(	PUNCT
ecletica-1173	253	4	1928a	1928a	NUM
ecletica-1173	253	5	,	,	PUNCT
ecletica-1173	253	6	b	b	NOUN
ecletica-1173	253	7	)	)	PUNCT
ecletica-1173	253	8	approach	approach	NOUN
ecletica-1173	253	9	,	,	PUNCT
ecletica-1173	253	10	for	for	ADP
ecletica-1173	253	11	example	example	NOUN
ecletica-1173	253	12	,	,	PUNCT
ecletica-1173	253	13	considers	consider	VERB
ecletica-1173	253	14	the	the	DET
ecletica-1173	253	15	interaction	interaction	NOUN
ecletica-1173	253	16	of	of	ADP
ecletica-1173	253	17	an	an	DET
ecletica-1173	253	18	electron	electron	NOUN
ecletica-1173	253	19	with	with	ADP
ecletica-1173	253	20	the	the	DET
ecletica-1173	253	21	average	average	ADJ
ecletica-1173	253	22	field	field	NOUN
ecletica-1173	253	23	generated	generate	VERB
ecletica-1173	253	24	by	by	ADP
ecletica-1173	253	25	the	the	DET
ecletica-1173	253	26	other	other	ADJ
ecletica-1173	253	27	electrons	electron	NOUN
ecletica-1173	253	28	.	.	PUNCT
ecletica-1173	254	1	jordan	jordan	PROPN
ecletica-1173	254	2	and	and	CCONJ
ecletica-1173	254	3	fock	fock	ADJ
ecletica-1173	254	4	(	(	PUNCT
ecletica-1173	254	5	1930	1930	NUM
ecletica-1173	254	6	)	)	PUNCT
ecletica-1173	254	7	introduced	introduce	VERB
ecletica-1173	254	8	the	the	DET
ecletica-1173	254	9	antisymmetric	antisymmetric	ADJ
ecletica-1173	254	10	fermion	fermion	NOUN
ecletica-1173	254	11	product	product	NOUN
ecletica-1173	254	12	in	in	ADP
ecletica-1173	254	13	hartree	hartree	PROPN
ecletica-1173	254	14	’s	’s	PART
ecletica-1173	254	15	method	method	NOUN
ecletica-1173	254	16	.	.	PUNCT
ecletica-1173	255	1	finally	finally	ADV
ecletica-1173	255	2	,	,	PUNCT
ecletica-1173	255	3	roothaan	roothaan	PROPN
ecletica-1173	255	4	(	(	PUNCT
ecletica-1173	255	5	1951	1951	NUM
ecletica-1173	255	6	)	)	PUNCT
ecletica-1173	255	7	added	add	VERB
ecletica-1173	255	8	the	the	DET
ecletica-1173	255	9	linear	linear	ADJ
ecletica-1173	255	10	combination	combination	NOUN
ecletica-1173	255	11	of	of	ADP
ecletica-1173	255	12	atomic	atomic	ADJ
ecletica-1173	255	13	orbitals	orbital	NOUN
ecletica-1173	255	14	to	to	ADP
ecletica-1173	255	15	the	the	DET
ecletica-1173	255	16	method	method	NOUN
ecletica-1173	255	17	.	.	PUNCT
ecletica-1173	256	1	hartree	hartree	PROPN
ecletica-1173	256	2	’s	’s	PART
ecletica-1173	256	3	initial	initial	ADJ
ecletica-1173	256	4	approximation	approximation	NOUN
ecletica-1173	256	5	contains	contain	VERB
ecletica-1173	256	6	a	a	DET
ecletica-1173	256	7	limit	limit	NOUN
ecletica-1173	256	8	in	in	ADP
ecletica-1173	256	9	the	the	DET
ecletica-1173	256	10	system	system	NOUN
ecletica-1173	256	11	energy	energy	NOUN
ecletica-1173	256	12	,	,	PUNCT
ecletica-1173	256	13	which	which	PRON
ecletica-1173	256	14	will	will	AUX
ecletica-1173	256	15	always	always	ADV
ecletica-1173	256	16	be	be	AUX
ecletica-1173	256	17	greater	great	ADJ
ecletica-1173	256	18	than	than	ADP
ecletica-1173	256	19	that	that	PRON
ecletica-1173	256	20	obtained	obtain	VERB
ecletica-1173	256	21	by	by	ADP
ecletica-1173	256	22	the	the	DET
ecletica-1173	256	23	exact	exact	ADJ
ecletica-1173	256	24	solution	solution	NOUN
ecletica-1173	256	25	of	of	ADP
ecletica-1173	256	26	the	the	DET
ecletica-1173	256	27	schrödinger	schrödinger	ADJ
ecletica-1173	256	28	equation	equation	NOUN
ecletica-1173	256	29	.	.	PUNCT
ecletica-1173	257	1	for	for	ADP
ecletica-1173	257	2	woolley	woolley	PROPN
ecletica-1173	257	3	(	(	PUNCT
ecletica-1173	257	4	1978	1978	NUM
ecletica-1173	257	5	)	)	PUNCT
ecletica-1173	257	6	,	,	PUNCT
ecletica-1173	257	7	the	the	DET
ecletica-1173	257	8	concept	concept	NOUN
ecletica-1173	257	9	of	of	ADP
ecletica-1173	257	10	molecular	molecular	ADJ
ecletica-1173	257	11	structure	structure	NOUN
ecletica-1173	257	12	is	be	AUX
ecletica-1173	257	13	http://revista.iq.unesp.br/ojs/index.php/ecletica/index	http://revista.iq.unesp.br/ojs/index.php/ecletica/index	NOUN
ecletica-1173	257	14	https://doi.org/10.26850/1678-4618eqj.v46.3.2021.p17-32	https://doi.org/10.26850/1678-4618eqj.v46.3.2021.p17-32	PROPN
ecletica-1173	257	15	review	review	NOUN
ecletica-1173	257	16	article	article	NOUN
ecletica-1173	257	17	iq.unesp.br/ecletica	iq.unesp.br/ecletica	PROPN
ecletica-1173	257	18	24	24	NUM
ecletica-1173	257	19	eclética	eclética	PROPN
ecletica-1173	257	20	química	química	PROPN
ecletica-1173	257	21	journal	journal	PROPN
ecletica-1173	257	22	,	,	PUNCT
ecletica-1173	257	23	vol	vol	NOUN
ecletica-1173	257	24	.	.	PROPN
ecletica-1173	257	25	46	46	NUM
ecletica-1173	257	26	,	,	PUNCT
ecletica-1173	257	27	n.	n.	NOUN
ecletica-1173	257	28	3	3	NUM
ecletica-1173	257	29	,	,	PUNCT
ecletica-1173	257	30	2021	2021	NUM
ecletica-1173	257	31	,	,	PUNCT
ecletica-1173	257	32	17	17	NUM
ecletica-1173	257	33	-	-	SYM
ecletica-1173	257	34	32	32	NUM
ecletica-1173	257	35	issn	issn	NOUN
ecletica-1173	257	36	:	:	PUNCT
ecletica-1173	257	37	1678	1678	NUM
ecletica-1173	257	38	-	-	SYM
ecletica-1173	257	39	4618	4618	NUM
ecletica-1173	257	40	doi	doi	NOUN
ecletica-1173	257	41	:	:	PUNCT
ecletica-1173	257	42	10.26850/1678	10.26850/1678	NUM
ecletica-1173	257	43	-	-	SYM
ecletica-1173	257	44	4618eqj.v46.3.2021.p17	4618eqj.v46.3.2021.p17	NOUN
ecletica-1173	257	45	-	-	PUNCT
ecletica-1173	257	46	32	32	NUM
ecletica-1173	257	47	absent	absent	ADJ
ecletica-1173	257	48	at	at	ADP
ecletica-1173	257	49	the	the	DET
ecletica-1173	257	50	actual	actual	ADJ
ecletica-1173	257	51	quantum	quantum	ADJ
ecletica-1173	257	52	level	level	NOUN
ecletica-1173	257	53	.	.	PUNCT
ecletica-1173	258	1	electronic	electronic	ADJ
ecletica-1173	258	2	structure	structure	NOUN
ecletica-1173	258	3	calculations	calculation	NOUN
ecletica-1173	258	4	are	be	AUX
ecletica-1173	258	5	based	base	VERB
ecletica-1173	258	6	on	on	ADP
ecletica-1173	258	7	approximations	approximation	NOUN
ecletica-1173	258	8	.	.	PUNCT
ecletica-1173	259	1	löwdin	löwdin	VERB
ecletica-1173	259	2	(	(	PUNCT
ecletica-1173	259	3	1955	1955	NUM
ecletica-1173	259	4	)	)	PUNCT
ecletica-1173	259	5	denominated	denominate	VERB
ecletica-1173	259	6	the	the	DET
ecletica-1173	259	7	difference	difference	NOUN
ecletica-1173	259	8	between	between	ADP
ecletica-1173	259	9	exact	exact	ADJ
ecletica-1173	259	10	energy	energy	NOUN
ecletica-1173	259	11	for	for	ADP
ecletica-1173	259	12	that	that	PRON
ecletica-1173	259	13	calculated	calculate	VERB
ecletica-1173	259	14	from	from	ADP
ecletica-1173	259	15	the	the	DET
ecletica-1173	259	16	ab	ab	PROPN
ecletica-1173	259	17	-	-	PUNCT
ecletica-1173	259	18	initio	initio	NOUN
ecletica-1173	259	19	approach	approach	NOUN
ecletica-1173	259	20	as	as	ADP
ecletica-1173	259	21	correlation	correlation	NOUN
ecletica-1173	259	22	energy	energy	NOUN
ecletica-1173	259	23	.	.	PUNCT
ecletica-1173	260	1	the	the	DET
ecletica-1173	260	2	lowest	low	ADJ
ecletica-1173	260	3	and	and	CCONJ
ecletica-1173	260	4	most	most	ADV
ecletica-1173	260	5	accurate	accurate	ADJ
ecletica-1173	260	6	energy	energy	NOUN
ecletica-1173	260	7	would	would	AUX
ecletica-1173	260	8	be	be	AUX
ecletica-1173	260	9	found	find	VERB
ecletica-1173	260	10	by	by	ADP
ecletica-1173	260	11	overcoming	overcome	VERB
ecletica-1173	260	12	the	the	DET
ecletica-1173	260	13	born	bear	VERB
ecletica-1173	260	14	–	–	PUNCT
ecletica-1173	260	15	oppenheimer	oppenheimer	NOUN
ecletica-1173	260	16	approximation	approximation	NOUN
ecletica-1173	260	17	and	and	CCONJ
ecletica-1173	260	18	by	by	ADP
ecletica-1173	260	19	inclusion	inclusion	NOUN
ecletica-1173	260	20	of	of	ADP
ecletica-1173	260	21	relativistic	relativistic	ADJ
ecletica-1173	260	22	corrections	correction	NOUN
ecletica-1173	260	23	.	.	PUNCT
ecletica-1173	261	1	post	post	VERB
ecletica-1173	261	2	hartree	hartree	ADJ
ecletica-1173	261	3	–	–	PUNCT
ecletica-1173	261	4	fock	fock	ADJ
ecletica-1173	261	5	approaches	approach	NOUN
ecletica-1173	261	6	named	name	VERB
ecletica-1173	261	7	coupled	couple	VERB
ecletica-1173	261	8	cluster	cluster	NOUN
ecletica-1173	261	9	use	use	NOUN
ecletica-1173	261	10	iterative	iterative	NOUN
ecletica-1173	261	11	single	single	ADJ
ecletica-1173	261	12	,	,	PUNCT
ecletica-1173	261	13	double	double	ADJ
ecletica-1173	261	14	and	and	CCONJ
ecletica-1173	261	15	triple	triple	ADJ
ecletica-1173	261	16	perturbative	perturbative	ADJ
ecletica-1173	261	17	excitations	excitation	NOUN
ecletica-1173	261	18	(	(	PUNCT
ecletica-1173	261	19	ccsd(t	ccsd(t	NOUN
ecletica-1173	261	20	)	)	PUNCT
ecletica-1173	261	21	)	)	PUNCT
ecletica-1173	261	22	that	that	PRON
ecletica-1173	261	23	are	be	AUX
ecletica-1173	261	24	able	able	ADJ
ecletica-1173	261	25	to	to	PART
ecletica-1173	261	26	perform	perform	VERB
ecletica-1173	261	27	calculations	calculation	NOUN
ecletica-1173	261	28	with	with	ADP
ecletica-1173	261	29	a	a	DET
ecletica-1173	261	30	precision	precision	NOUN
ecletica-1173	261	31	of	of	ADP
ecletica-1173	261	32	±	±	NUM
ecletica-1173	261	33	5	5	NUM
ecletica-1173	261	34	kj	kj	NOUN
ecletica-1173	261	35	mol–1	mol–1	NOUN
ecletica-1173	261	36	for	for	ADP
ecletica-1173	261	37	small	small	ADJ
ecletica-1173	261	38	and	and	CCONJ
ecletica-1173	261	39	medium	medium	ADJ
ecletica-1173	261	40	molecules	molecule	NOUN
ecletica-1173	261	41	(	(	PUNCT
ecletica-1173	261	42	kümmel	kümmel	PROPN
ecletica-1173	261	43	,	,	PUNCT
ecletica-1173	261	44	2002	2002	NUM
ecletica-1173	261	45	;	;	PUNCT
ecletica-1173	261	46	shavitt	shavitt	PROPN
ecletica-1173	261	47	and	and	CCONJ
ecletica-1173	261	48	bartlett	bartlett	PROPN
ecletica-1173	261	49	,	,	PUNCT
ecletica-1173	261	50	2009	2009	NUM
ecletica-1173	261	51	)	)	PUNCT
ecletica-1173	261	52	.	.	PUNCT
ecletica-1173	262	1	there	there	PRON
ecletica-1173	262	2	is	be	VERB
ecletica-1173	262	3	still	still	ADV
ecletica-1173	262	4	the	the	DET
ecletica-1173	262	5	problem	problem	NOUN
ecletica-1173	262	6	with	with	ADP
ecletica-1173	262	7	computational	computational	ADJ
ecletica-1173	262	8	time	time	NOUN
ecletica-1173	262	9	.	.	PUNCT
ecletica-1173	263	1	robust	robust	ADJ
ecletica-1173	263	2	calculations	calculation	NOUN
ecletica-1173	263	3	,	,	PUNCT
ecletica-1173	263	4	such	such	ADJ
ecletica-1173	263	5	as	as	ADP
ecletica-1173	263	6	those	those	PRON
ecletica-1173	263	7	derived	derive	VERB
ecletica-1173	263	8	from	from	ADP
ecletica-1173	263	9	møller	møller	ADJ
ecletica-1173	263	10	–	–	PUNCT
ecletica-1173	263	11	plesset	plesset	ADJ
ecletica-1173	263	12	perturbation	perturbation	NOUN
ecletica-1173	263	13	theory	theory	NOUN
ecletica-1173	263	14	(	(	PUNCT
ecletica-1173	263	15	mp2	mp2	PROPN
ecletica-1173	263	16	and	and	CCONJ
ecletica-1173	263	17	mp3	mp3	NOUN
ecletica-1173	263	18	methods	method	NOUN
ecletica-1173	263	19	)	)	PUNCT
ecletica-1173	263	20	and	and	CCONJ
ecletica-1173	263	21	those	those	DET
ecletica-1173	263	22	approaches	approach	NOUN
ecletica-1173	263	23	that	that	PRON
ecletica-1173	263	24	use	use	VERB
ecletica-1173	263	25	double	double	ADJ
ecletica-1173	263	26	and	and	CCONJ
ecletica-1173	263	27	triple	triple	ADJ
ecletica-1173	263	28	excitations	excitation	NOUN
ecletica-1173	263	29	are	be	AUX
ecletica-1173	263	30	computationally	computationally	ADV
ecletica-1173	263	31	unviable	unviable	ADJ
ecletica-1173	263	32	for	for	ADP
ecletica-1173	263	33	the	the	DET
ecletica-1173	263	34	treatment	treatment	NOUN
ecletica-1173	263	35	of	of	ADP
ecletica-1173	263	36	biomolecules	biomolecule	NOUN
ecletica-1173	263	37	.	.	PUNCT
ecletica-1173	264	1	the	the	DET
ecletica-1173	264	2	classic	classic	ADJ
ecletica-1173	264	3	force	force	NOUN
ecletica-1173	264	4	fields	field	NOUN
ecletica-1173	264	5	are	be	AUX
ecletica-1173	264	6	employed	employ	VERB
ecletica-1173	264	7	to	to	PART
ecletica-1173	264	8	study	study	VERB
ecletica-1173	264	9	biological	biological	ADJ
ecletica-1173	264	10	molecules	molecule	NOUN
ecletica-1173	264	11	.	.	PUNCT
ecletica-1173	265	1	in	in	ADP
ecletica-1173	265	2	this	this	DET
ecletica-1173	265	3	method	method	NOUN
ecletica-1173	265	4	,	,	PUNCT
ecletica-1173	265	5	quantum	quantum	ADJ
ecletica-1173	265	6	mechanics	mechanic	NOUN
ecletica-1173	265	7	is	be	AUX
ecletica-1173	265	8	replaced	replace	VERB
ecletica-1173	265	9	by	by	ADP
ecletica-1173	265	10	classical	classical	ADJ
ecletica-1173	265	11	mechanics	mechanic	NOUN
ecletica-1173	265	12	.	.	PUNCT
ecletica-1173	266	1	electrons	electron	NOUN
ecletica-1173	266	2	are	be	AUX
ecletica-1173	266	3	forgotten	forget	VERB
ecletica-1173	266	4	and	and	CCONJ
ecletica-1173	266	5	chemical	chemical	NOUN
ecletica-1173	266	6	bonds	bond	NOUN
ecletica-1173	266	7	are	be	AUX
ecletica-1173	266	8	treated	treat	VERB
ecletica-1173	266	9	as	as	ADP
ecletica-1173	266	10	springmass	springmass	PROPN
ecletica-1173	266	11	systems	system	NOUN
ecletica-1173	266	12	.	.	PUNCT
ecletica-1173	267	1	interactions	interaction	NOUN
ecletica-1173	267	2	are	be	AUX
ecletica-1173	267	3	described	describe	VERB
ecletica-1173	267	4	by	by	ADP
ecletica-1173	267	5	electrostatic	electrostatic	ADJ
ecletica-1173	267	6	and	and	CCONJ
ecletica-1173	267	7	van	van	PROPN
ecletica-1173	267	8	der	der	NOUN
ecletica-1173	267	9	waals	waal	NOUN
ecletica-1173	267	10	equations	equation	NOUN
ecletica-1173	267	11	.	.	PUNCT
ecletica-1173	268	1	this	this	DET
ecletica-1173	268	2	method	method	NOUN
ecletica-1173	268	3	is	be	AUX
ecletica-1173	268	4	the	the	DET
ecletica-1173	268	5	molecular	molecular	ADJ
ecletica-1173	268	6	mechanics	mechanic	NOUN
ecletica-1173	268	7	(	(	PUNCT
ecletica-1173	268	8	kümmel	kümmel	PROPN
ecletica-1173	268	9	,	,	PUNCT
ecletica-1173	268	10	2002	2002	NUM
ecletica-1173	268	11	;	;	PUNCT
ecletica-1173	268	12	leach	leach	NOUN
ecletica-1173	268	13	,	,	PUNCT
ecletica-1173	268	14	2001	2001	NUM
ecletica-1173	268	15	)	)	PUNCT
ecletica-1173	268	16	that	that	PRON
ecletica-1173	268	17	allows	allow	VERB
ecletica-1173	268	18	the	the	DET
ecletica-1173	268	19	study	study	NOUN
ecletica-1173	268	20	of	of	ADP
ecletica-1173	268	21	optimization	optimization	NOUN
ecletica-1173	268	22	and	and	CCONJ
ecletica-1173	268	23	dynamics	dynamic	NOUN
ecletica-1173	268	24	of	of	ADP
ecletica-1173	268	25	proteins	protein	NOUN
ecletica-1173	268	26	and	and	CCONJ
ecletica-1173	268	27	other	other	ADJ
ecletica-1173	268	28	biological	biological	ADJ
ecletica-1173	268	29	molecules	molecule	NOUN
ecletica-1173	268	30	.	.	PUNCT
ecletica-1173	269	1	systematic	systematic	ADJ
ecletica-1173	269	2	validations	validation	NOUN
ecletica-1173	269	3	based	base	VERB
ecletica-1173	269	4	on	on	ADP
ecletica-1173	269	5	quantum	quantum	ADJ
ecletica-1173	269	6	mechanics	mechanic	NOUN
ecletica-1173	269	7	have	have	AUX
ecletica-1173	269	8	been	be	AUX
ecletica-1173	269	9	performed	perform	VERB
ecletica-1173	269	10	in	in	ADP
ecletica-1173	269	11	order	order	NOUN
ecletica-1173	269	12	to	to	PART
ecletica-1173	269	13	standardize	standardize	VERB
ecletica-1173	269	14	the	the	DET
ecletica-1173	269	15	molecular	molecular	ADJ
ecletica-1173	269	16	force	force	NOUN
ecletica-1173	269	17	fields	field	NOUN
ecletica-1173	269	18	(	(	PUNCT
ecletica-1173	269	19	van	van	PROPN
ecletica-1173	269	20	der	der	PROPN
ecletica-1173	269	21	spoel	spoel	PROPN
ecletica-1173	269	22	,	,	PUNCT
ecletica-1173	269	23	2021	2021	NUM
ecletica-1173	269	24	)	)	PUNCT
ecletica-1173	269	25	.	.	PUNCT
ecletica-1173	270	1	rational	rational	ADJ
ecletica-1173	270	2	drug	drug	NOUN
ecletica-1173	270	3	design	design	NOUN
ecletica-1173	270	4	at	at	ADP
ecletica-1173	270	5	the	the	DET
ecletica-1173	270	6	molecular	molecular	ADJ
ecletica-1173	270	7	level	level	NOUN
ecletica-1173	270	8	is	be	AUX
ecletica-1173	270	9	generally	generally	ADV
ecletica-1173	270	10	based	base	VERB
ecletica-1173	270	11	on	on	ADP
ecletica-1173	270	12	x	x	ADJ
ecletica-1173	270	13	-	-	NOUN
ecletica-1173	270	14	ray	ray	NOUN
ecletica-1173	270	15	diffraction	diffraction	NOUN
ecletica-1173	270	16	.	.	PUNCT
ecletica-1173	271	1	in	in	ADP
ecletica-1173	271	2	this	this	DET
ecletica-1173	271	3	technique	technique	NOUN
ecletica-1173	271	4	,	,	PUNCT
ecletica-1173	271	5	the	the	DET
ecletica-1173	271	6	position	position	NOUN
ecletica-1173	271	7	of	of	ADP
ecletica-1173	271	8	atoms	atom	NOUN
ecletica-1173	271	9	in	in	ADP
ecletica-1173	271	10	the	the	DET
ecletica-1173	271	11	crystal	crystal	NOUN
ecletica-1173	271	12	is	be	AUX
ecletica-1173	271	13	determined	determine	VERB
ecletica-1173	271	14	to	to	PART
ecletica-1173	271	15	obtain	obtain	VERB
ecletica-1173	271	16	the	the	DET
ecletica-1173	271	17	three	three	NUM
ecletica-1173	271	18	-	-	PUNCT
ecletica-1173	271	19	dimensional	dimensional	ADJ
ecletica-1173	271	20	structure	structure	NOUN
ecletica-1173	271	21	of	of	ADP
ecletica-1173	271	22	the	the	DET
ecletica-1173	271	23	biomolecule	biomolecule	NOUN
ecletica-1173	271	24	.	.	PUNCT
ecletica-1173	272	1	this	this	DET
ecletica-1173	272	2	structure	structure	NOUN
ecletica-1173	272	3	can	can	AUX
ecletica-1173	272	4	be	be	AUX
ecletica-1173	272	5	studied	study	VERB
ecletica-1173	272	6	as	as	ADP
ecletica-1173	272	7	a	a	DET
ecletica-1173	272	8	whole	whole	NOUN
ecletica-1173	272	9	with	with	ADP
ecletica-1173	272	10	classical	classical	ADJ
ecletica-1173	272	11	mechanics	mechanic	NOUN
ecletica-1173	272	12	.	.	PUNCT
ecletica-1173	273	1	there	there	PRON
ecletica-1173	273	2	is	be	VERB
ecletica-1173	273	3	also	also	ADV
ecletica-1173	273	4	the	the	DET
ecletica-1173	273	5	possibility	possibility	NOUN
ecletica-1173	273	6	of	of	ADP
ecletica-1173	273	7	temporal	temporal	ADJ
ecletica-1173	273	8	evolution	evolution	NOUN
ecletica-1173	273	9	of	of	ADP
ecletica-1173	273	10	the	the	DET
ecletica-1173	273	11	system	system	NOUN
ecletica-1173	273	12	using	use	VERB
ecletica-1173	273	13	classical	classical	ADJ
ecletica-1173	273	14	force	force	NOUN
ecletica-1173	273	15	fields	field	NOUN
ecletica-1173	273	16	associated	associate	VERB
ecletica-1173	273	17	with	with	ADP
ecletica-1173	273	18	the	the	DET
ecletica-1173	273	19	integration	integration	NOUN
ecletica-1173	273	20	of	of	ADP
ecletica-1173	273	21	newton	newton	PROPN
ecletica-1173	273	22	’s	’s	PART
ecletica-1173	273	23	equations	equation	NOUN
ecletica-1173	273	24	step	step	VERB
ecletica-1173	273	25	by	by	ADP
ecletica-1173	273	26	step	step	NOUN
ecletica-1173	273	27	in	in	ADP
ecletica-1173	273	28	time	time	NOUN
ecletica-1173	273	29	.	.	PUNCT
ecletica-1173	274	1	this	this	DET
ecletica-1173	274	2	technique	technique	NOUN
ecletica-1173	274	3	is	be	AUX
ecletica-1173	274	4	known	know	VERB
ecletica-1173	274	5	as	as	ADP
ecletica-1173	274	6	molecular	molecular	ADJ
ecletica-1173	274	7	dynamics	dynamic	NOUN
ecletica-1173	274	8	.	.	PUNCT
ecletica-1173	275	1	the	the	DET
ecletica-1173	275	2	longest	long	ADJ
ecletica-1173	275	3	molecular	molecular	ADJ
ecletica-1173	275	4	dynamic	dynamic	NOUN
ecletica-1173	275	5	ever	ever	ADV
ecletica-1173	275	6	performed	perform	VERB
ecletica-1173	275	7	was	be	AUX
ecletica-1173	275	8	on	on	ADP
ecletica-1173	275	9	the	the	DET
ecletica-1173	275	10	order	order	NOUN
ecletica-1173	275	11	of	of	ADP
ecletica-1173	275	12	10–6	10–6	PROPN
ecletica-1173	275	13	s.	s.	NOUN
ecletica-1173	275	14	the	the	DET
ecletica-1173	275	15	problem	problem	NOUN
ecletica-1173	275	16	is	be	AUX
ecletica-1173	275	17	that	that	SCONJ
ecletica-1173	275	18	some	some	DET
ecletica-1173	275	19	biochemical	biochemical	ADJ
ecletica-1173	275	20	mechanisms	mechanism	NOUN
ecletica-1173	275	21	,	,	PUNCT
ecletica-1173	275	22	such	such	ADJ
ecletica-1173	275	23	as	as	ADP
ecletica-1173	275	24	protein	protein	NOUN
ecletica-1173	275	25	folding	folding	NOUN
ecletica-1173	275	26	,	,	PUNCT
ecletica-1173	275	27	are	be	AUX
ecletica-1173	275	28	in	in	ADP
ecletica-1173	275	29	the	the	DET
ecletica-1173	275	30	temporal	temporal	ADJ
ecletica-1173	275	31	interstice	interstice	NOUN
ecletica-1173	275	32	of	of	ADP
ecletica-1173	275	33	10–3	10–3	PROPN
ecletica-1173	275	34	s.	s.	PROPN
ecletica-1173	275	35	in	in	ADP
ecletica-1173	275	36	the	the	DET
ecletica-1173	275	37	study	study	NOUN
ecletica-1173	275	38	of	of	ADP
ecletica-1173	275	39	structure	structure	NOUN
ecletica-1173	275	40	and	and	CCONJ
ecletica-1173	275	41	activity	activity	NOUN
ecletica-1173	275	42	relationship	relationship	NOUN
ecletica-1173	275	43	(	(	PUNCT
ecletica-1173	275	44	sar	sar	PROPN
ecletica-1173	275	45	)	)	PUNCT
ecletica-1173	275	46	,	,	PUNCT
ecletica-1173	275	47	the	the	DET
ecletica-1173	275	48	activity	activity	NOUN
ecletica-1173	275	49	of	of	ADP
ecletica-1173	275	50	a	a	DET
ecletica-1173	275	51	set	set	NOUN
ecletica-1173	275	52	of	of	ADP
ecletica-1173	275	53	known	know	VERB
ecletica-1173	275	54	drugs	drug	NOUN
ecletica-1173	275	55	can	can	AUX
ecletica-1173	275	56	be	be	AUX
ecletica-1173	275	57	correlated	correlate	VERB
ecletica-1173	275	58	with	with	ADP
ecletica-1173	275	59	a	a	DET
ecletica-1173	275	60	series	series	NOUN
ecletica-1173	275	61	of	of	ADP
ecletica-1173	275	62	their	their	PRON
ecletica-1173	275	63	physicochemical	physicochemical	ADJ
ecletica-1173	275	64	properties	property	NOUN
ecletica-1173	275	65	.	.	PUNCT
ecletica-1173	276	1	the	the	DET
ecletica-1173	276	2	idea	idea	NOUN
ecletica-1173	276	3	behind	behind	ADP
ecletica-1173	276	4	this	this	DET
ecletica-1173	276	5	technique	technique	NOUN
ecletica-1173	276	6	is	be	AUX
ecletica-1173	276	7	to	to	PART
ecletica-1173	276	8	construct	construct	VERB
ecletica-1173	276	9	a	a	DET
ecletica-1173	276	10	multilinear	multilinear	NOUN
ecletica-1173	276	11	regression	regression	NOUN
ecletica-1173	276	12	curve	curve	NOUN
ecletica-1173	276	13	that	that	PRON
ecletica-1173	276	14	relates	relate	VERB
ecletica-1173	276	15	known	know	VERB
ecletica-1173	276	16	drug	drug	NOUN
ecletica-1173	276	17	activity	activity	NOUN
ecletica-1173	276	18	to	to	ADP
ecletica-1173	276	19	a	a	DET
ecletica-1173	276	20	particular	particular	ADJ
ecletica-1173	276	21	universe	universe	NOUN
ecletica-1173	276	22	of	of	ADP
ecletica-1173	276	23	physicochemical	physicochemical	ADJ
ecletica-1173	276	24	properties	property	NOUN
ecletica-1173	276	25	.	.	PUNCT
ecletica-1173	277	1	the	the	DET
ecletica-1173	277	2	graph	graph	NOUN
ecletica-1173	277	3	allows	allow	VERB
ecletica-1173	277	4	the	the	DET
ecletica-1173	277	5	inferences	inference	NOUN
ecletica-1173	277	6	of	of	ADP
ecletica-1173	277	7	the	the	DET
ecletica-1173	277	8	activity	activity	NOUN
ecletica-1173	277	9	of	of	ADP
ecletica-1173	277	10	a	a	DET
ecletica-1173	277	11	new	new	ADJ
ecletica-1173	277	12	drug	drug	NOUN
ecletica-1173	277	13	before	before	ADP
ecletica-1173	277	14	the	the	DET
ecletica-1173	277	15	synthesis	synthesis	NOUN
ecletica-1173	277	16	.	.	PUNCT
ecletica-1173	278	1	fundamental	fundamental	ADJ
ecletica-1173	278	2	presumption	presumption	NOUN
ecletica-1173	278	3	for	for	ADP
ecletica-1173	278	4	qsar	qsar	NOUN
ecletica-1173	278	5	is	be	AUX
ecletica-1173	278	6	that	that	SCONJ
ecletica-1173	278	7	comparable	comparable	ADJ
ecletica-1173	278	8	molecules	molecule	NOUN
ecletica-1173	278	9	have	have	VERB
ecletica-1173	278	10	comparable	comparable	ADJ
ecletica-1173	278	11	activities	activity	NOUN
ecletica-1173	278	12	.	.	PUNCT
ecletica-1173	279	1	this	this	DET
ecletica-1173	279	2	rule	rule	NOUN
ecletica-1173	279	3	is	be	AUX
ecletica-1173	279	4	called	call	VERB
ecletica-1173	279	5	the	the	DET
ecletica-1173	279	6	structure	structure	NOUN
ecletica-1173	279	7	-	-	PUNCT
ecletica-1173	279	8	activity	activity	NOUN
ecletica-1173	279	9	relationship	relationship	NOUN
ecletica-1173	279	10	.	.	PUNCT
ecletica-1173	280	1	the	the	DET
ecletica-1173	280	2	fundamental	fundamental	ADJ
ecletica-1173	280	3	issue	issue	NOUN
ecletica-1173	280	4	is	be	AUX
ecletica-1173	280	5	how	how	SCONJ
ecletica-1173	280	6	to	to	PART
ecletica-1173	280	7	characterize	characterize	VERB
ecletica-1173	280	8	a	a	DET
ecletica-1173	280	9	little	little	ADJ
ecletica-1173	280	10	distinction	distinction	NOUN
ecletica-1173	280	11	at	at	ADP
ecletica-1173	280	12	the	the	DET
ecletica-1173	280	13	molecule	molecule	NOUN
ecletica-1173	280	14	level	level	NOUN
ecletica-1173	280	15	,	,	PUNCT
ecletica-1173	280	16	since	since	SCONJ
ecletica-1173	280	17	each	each	DET
ecletica-1173	280	18	sort	sort	NOUN
ecletica-1173	280	19	of	of	ADP
ecletica-1173	280	20	movement	movement	NOUN
ecletica-1173	280	21	and	and	CCONJ
ecletica-1173	280	22	response	response	NOUN
ecletica-1173	280	23	capacity	capacity	NOUN
ecletica-1173	280	24	,	,	PUNCT
ecletica-1173	280	25	biotransformation	biotransformation	NOUN
ecletica-1173	280	26	capacity	capacity	NOUN
ecletica-1173	280	27	,	,	PUNCT
ecletica-1173	280	28	solvency	solvency	NOUN
ecletica-1173	280	29	,	,	PUNCT
ecletica-1173	280	30	target	target	NOUN
ecletica-1173	280	31	movement	movement	NOUN
ecletica-1173	280	32	,	,	PUNCT
ecletica-1173	280	33	and	and	CCONJ
ecletica-1173	280	34	so	so	ADV
ecletica-1173	280	35	on	on	ADV
ecletica-1173	280	36	,	,	PUNCT
ecletica-1173	280	37	may	may	AUX
ecletica-1173	280	38	depend	depend	VERB
ecletica-1173	280	39	on	on	ADP
ecletica-1173	280	40	another	another	DET
ecletica-1173	280	41	distinction	distinction	NOUN
ecletica-1173	280	42	.	.	PUNCT
ecletica-1173	281	1	great	great	ADJ
ecletica-1173	281	2	examples	example	NOUN
ecletica-1173	281	3	have	have	AUX
ecletica-1173	281	4	been	be	AUX
ecletica-1173	281	5	given	give	VERB
ecletica-1173	281	6	in	in	ADP
ecletica-1173	281	7	the	the	DET
ecletica-1173	281	8	literature	literature	NOUN
ecletica-1173	281	9	(	(	PUNCT
ecletica-1173	281	10	brown	brown	PROPN
ecletica-1173	281	11	,	,	PUNCT
ecletica-1173	281	12	2012	2012	NUM
ecletica-1173	281	13	;	;	PUNCT
ecletica-1173	281	14	patani	patani	NOUN
ecletica-1173	281	15	and	and	CCONJ
ecletica-1173	281	16	lavoie	lavoie	PROPN
ecletica-1173	281	17	,	,	PUNCT
ecletica-1173	281	18	1996	1996	NUM
ecletica-1173	281	19	)	)	PUNCT
ecletica-1173	281	20	.	.	PUNCT
ecletica-1173	282	1	the	the	DET
ecletica-1173	282	2	speculations	speculation	NOUN
ecletica-1173	282	3	depend	depend	VERB
ecletica-1173	282	4	on	on	ADP
ecletica-1173	282	5	a	a	DET
ecletica-1173	282	6	limited	limited	ADJ
ecletica-1173	282	7	amount	amount	NOUN
ecletica-1173	282	8	of	of	ADP
ecletica-1173	282	9	chemical	chemical	ADJ
ecletica-1173	282	10	information	information	NOUN
ecletica-1173	282	11	.	.	PUNCT
ecletica-1173	283	1	the	the	DET
ecletica-1173	283	2	rule	rule	NOUN
ecletica-1173	283	3	of	of	ADP
ecletica-1173	283	4	acceptance	acceptance	NOUN
ecletica-1173	283	5	must	must	AUX
ecletica-1173	283	6	be	be	AUX
ecletica-1173	283	7	regarded	regard	VERB
ecletica-1173	283	8	to	to	PART
ecletica-1173	283	9	maintain	maintain	VERB
ecletica-1173	283	10	a	a	DET
ecletica-1173	283	11	strategic	strategic	ADJ
ecletica-1173	283	12	distance	distance	NOUN
ecletica-1173	283	13	from	from	ADP
ecletica-1173	283	14	over	over	ADP
ecletica-1173	283	15	adjusted	adjust	VERB
ecletica-1173	283	16	theories	theory	NOUN
ecletica-1173	283	17	and	and	CCONJ
ecletica-1173	283	18	to	to	PART
ecletica-1173	283	19	determine	determine	VERB
ecletica-1173	283	20	over	over	ADP
ecletica-1173	283	21	adjusted	adjusted	ADJ
ecletica-1173	283	22	elucidations	elucidation	NOUN
ecletica-1173	283	23	in	in	ADP
ecletica-1173	283	24	basic	basic	ADJ
ecletica-1173	283	25	molecular	molecular	ADJ
ecletica-1173	283	26	information	information	NOUN
ecletica-1173	283	27	.	.	PUNCT
ecletica-1173	284	1	the	the	DET
ecletica-1173	284	2	reality	reality	NOUN
ecletica-1173	284	3	is	be	AUX
ecletica-1173	284	4	that	that	SCONJ
ecletica-1173	284	5	not	not	PART
ecletica-1173	284	6	all	all	DET
ecletica-1173	284	7	comparative	comparative	ADJ
ecletica-1173	284	8	molecules	molecule	NOUN
ecletica-1173	284	9	have	have	VERB
ecletica-1173	284	10	comparative	comparative	ADJ
ecletica-1173	284	11	activities	activity	NOUN
ecletica-1173	284	12	.	.	PUNCT
ecletica-1173	285	1	it	it	PRON
ecletica-1173	285	2	was	be	AUX
ecletica-1173	285	3	shown	show	VERB
ecletica-1173	285	4	several	several	ADJ
ecletica-1173	285	5	reductionism	reductionism	NOUN
ecletica-1173	285	6	kinds	kind	NOUN
ecletica-1173	285	7	.	.	PUNCT
ecletica-1173	286	1	dirac	dirac	NOUN
ecletica-1173	286	2	(	(	PUNCT
ecletica-1173	286	3	1929	1929	NUM
ecletica-1173	286	4	)	)	PUNCT
ecletica-1173	286	5	defends	defend	VERB
ecletica-1173	286	6	a	a	DET
ecletica-1173	286	7	complete	complete	ADJ
ecletica-1173	286	8	epistemological	epistemological	ADJ
ecletica-1173	286	9	reductionism	reductionism	NOUN
ecletica-1173	286	10	,	,	PUNCT
ecletica-1173	286	11	which	which	DET
ecletica-1173	286	12	quantum	quantum	NOUN
ecletica-1173	286	13	mechanics	mechanic	NOUN
ecletica-1173	286	14	premises	premise	NOUN
ecletica-1173	286	15	is	be	AUX
ecletica-1173	286	16	the	the	DET
ecletica-1173	286	17	primary	primary	ADJ
ecletica-1173	286	18	theory	theory	NOUN
ecletica-1173	286	19	and	and	CCONJ
ecletica-1173	286	20	the	the	DET
ecletica-1173	286	21	conclusion	conclusion	NOUN
ecletica-1173	286	22	is	be	AUX
ecletica-1173	286	23	chemistry	chemistry	NOUN
ecletica-1173	286	24	.	.	PUNCT
ecletica-1173	287	1	on	on	ADP
ecletica-1173	287	2	the	the	DET
ecletica-1173	287	3	other	other	ADJ
ecletica-1173	287	4	hand	hand	NOUN
ecletica-1173	287	5	,	,	PUNCT
ecletica-1173	287	6	crick	crick	NOUN
ecletica-1173	287	7	(	(	PUNCT
ecletica-1173	287	8	1966	1966	NUM
ecletica-1173	287	9	)	)	PUNCT
ecletica-1173	287	10	argues	argue	VERB
ecletica-1173	287	11	that	that	SCONJ
ecletica-1173	287	12	biology	biology	NOUN
ecletica-1173	287	13	can	can	AUX
ecletica-1173	287	14	be	be	AUX
ecletica-1173	287	15	reduced	reduce	VERB
ecletica-1173	287	16	to	to	ADP
ecletica-1173	287	17	chemical	chemical	ADJ
ecletica-1173	287	18	reactions	reaction	NOUN
ecletica-1173	287	19	.	.	PUNCT
ecletica-1173	288	1	both	both	DET
ecletica-1173	288	2	these	these	DET
ecletica-1173	288	3	propositions	proposition	NOUN
ecletica-1173	288	4	were	be	AUX
ecletica-1173	288	5	criticized	criticize	VERB
ecletica-1173	288	6	,	,	PUNCT
ecletica-1173	288	7	showing	show	VERB
ecletica-1173	288	8	arguments	argument	NOUN
ecletica-1173	288	9	against	against	ADP
ecletica-1173	288	10	this	this	DET
ecletica-1173	288	11	kind	kind	NOUN
ecletica-1173	288	12	of	of	ADP
ecletica-1173	288	13	reductionism	reductionism	NOUN
ecletica-1173	288	14	.	.	PUNCT
ecletica-1173	289	1	it	it	PRON
ecletica-1173	289	2	is	be	AUX
ecletica-1173	289	3	important	important	ADJ
ecletica-1173	289	4	to	to	PART
ecletica-1173	289	5	declare	declare	VERB
ecletica-1173	289	6	that	that	SCONJ
ecletica-1173	289	7	biology	biology	NOUN
ecletica-1173	289	8	developed	develop	VERB
ecletica-1173	289	9	itself	itself	PRON
ecletica-1173	289	10	without	without	ADP
ecletica-1173	289	11	the	the	DET
ecletica-1173	289	12	knowledge	knowledge	NOUN
ecletica-1173	289	13	of	of	ADP
ecletica-1173	289	14	chemistry	chemistry	NOUN
ecletica-1173	289	15	.	.	PUNCT
ecletica-1173	290	1	there	there	PRON
ecletica-1173	290	2	is	be	VERB
ecletica-1173	290	3	not	not	PART
ecletica-1173	290	4	a	a	DET
ecletica-1173	290	5	causal	causal	ADJ
ecletica-1173	290	6	dependence	dependence	NOUN
ecletica-1173	290	7	between	between	ADP
ecletica-1173	290	8	chemistry	chemistry	NOUN
ecletica-1173	290	9	,	,	PUNCT
ecletica-1173	290	10	biology	biology	NOUN
ecletica-1173	290	11	and	and	CCONJ
ecletica-1173	290	12	physics	physics	NOUN
ecletica-1173	290	13	.	.	PUNCT
ecletica-1173	291	1	however	however	ADV
ecletica-1173	291	2	,	,	PUNCT
ecletica-1173	291	3	methodological	methodological	ADJ
ecletica-1173	291	4	reductionism	reductionism	NOUN
ecletica-1173	291	5	is	be	AUX
ecletica-1173	291	6	applied	apply	VERB
ecletica-1173	291	7	nowadays	nowadays	ADV
ecletica-1173	291	8	to	to	PART
ecletica-1173	291	9	begin	begin	VERB
ecletica-1173	291	10	the	the	DET
ecletica-1173	291	11	studies	study	NOUN
ecletica-1173	291	12	in	in	ADP
ecletica-1173	291	13	drug	drug	NOUN
ecletica-1173	291	14	design	design	NOUN
ecletica-1173	291	15	.	.	PUNCT
ecletica-1173	292	1	it	it	PRON
ecletica-1173	292	2	will	will	AUX
ecletica-1173	292	3	show	show	VERB
ecletica-1173	292	4	the	the	DET
ecletica-1173	292	5	problems	problem	NOUN
ecletica-1173	292	6	associated	associate	VERB
ecletica-1173	292	7	with	with	ADP
ecletica-1173	292	8	methodological	methodological	ADJ
ecletica-1173	292	9	reductionism	reductionism	NOUN
ecletica-1173	292	10	.	.	PUNCT
ecletica-1173	293	1	the	the	DET
ecletica-1173	293	2	holistic	holistic	ADJ
ecletica-1173	293	3	approaches	approach	NOUN
ecletica-1173	293	4	that	that	PRON
ecletica-1173	293	5	can	can	AUX
ecletica-1173	293	6	be	be	AUX
ecletica-1173	293	7	used	use	VERB
ecletica-1173	293	8	to	to	PART
ecletica-1173	293	9	work	work	VERB
ecletica-1173	293	10	with	with	ADP
ecletica-1173	293	11	drug	drug	NOUN
ecletica-1173	293	12	design	design	NOUN
ecletica-1173	293	13	will	will	AUX
ecletica-1173	293	14	be	be	AUX
ecletica-1173	293	15	described	describe	VERB
ecletica-1173	293	16	as	as	ADP
ecletica-1173	293	17	an	an	DET
ecletica-1173	293	18	alternative	alternative	NOUN
ecletica-1173	293	19	to	to	ADP
ecletica-1173	293	20	approaches	approach	NOUN
ecletica-1173	293	21	merely	merely	ADV
ecletica-1173	293	22	reductionist	reductionist	ADJ
ecletica-1173	293	23	.	.	PUNCT
ecletica-1173	294	1	7	7	X
ecletica-1173	294	2	.	.	X
ecletica-1173	294	3	the	the	DET
ecletica-1173	294	4	problem	problem	NOUN
ecletica-1173	294	5	in	in	ADP
ecletica-1173	294	6	design	design	NOUN
ecletica-1173	294	7	of	of	ADP
ecletica-1173	294	8	new	new	ADJ
ecletica-1173	294	9	drugs	drug	NOUN
ecletica-1173	294	10	the	the	DET
ecletica-1173	294	11	number	number	NOUN
ecletica-1173	294	12	of	of	ADP
ecletica-1173	294	13	modern	modern	ADJ
ecletica-1173	294	14	drugs	drug	NOUN
ecletica-1173	294	15	approved	approve	VERB
ecletica-1173	294	16	by	by	ADP
ecletica-1173	294	17	food	food	NOUN
ecletica-1173	294	18	and	and	CCONJ
ecletica-1173	294	19	drug	drug	PROPN
ecletica-1173	294	20	administration	administration	PROPN
ecletica-1173	294	21	(	(	PUNCT
ecletica-1173	294	22	fda	fda	PROPN
ecletica-1173	294	23	)	)	PUNCT
ecletica-1173	294	24	diminished	diminish	VERB
ecletica-1173	294	25	over	over	ADP
ecletica-1173	294	26	the	the	DET
ecletica-1173	294	27	last	last	ADJ
ecletica-1173	294	28	years	year	NOUN
ecletica-1173	294	29	.	.	PUNCT
ecletica-1173	295	1	the	the	DET
ecletica-1173	295	2	number	number	NOUN
ecletica-1173	295	3	of	of	ADP
ecletica-1173	295	4	approved	approve	VERB
ecletica-1173	295	5	drugs	drug	NOUN
ecletica-1173	295	6	reduced	reduce	VERB
ecletica-1173	295	7	from	from	ADP
ecletica-1173	295	8	10	10	NUM
ecletica-1173	295	9	to	to	PART
ecletica-1173	295	10	20	20	NUM
ecletica-1173	295	11	during	during	ADP
ecletica-1173	295	12	the	the	DET
ecletica-1173	295	13	year	year	NOUN
ecletica-1173	295	14	of	of	ADP
ecletica-1173	295	15	2002	2002	NUM
ecletica-1173	295	16	.	.	PUNCT
ecletica-1173	296	1	this	this	DET
ecletica-1173	296	2	decline	decline	NOUN
ecletica-1173	296	3	has	have	AUX
ecletica-1173	296	4	been	be	AUX
ecletica-1173	296	5	held	hold	VERB
ecletica-1173	296	6	in	in	ADP
ecletica-1173	296	7	spite	spite	NOUN
ecletica-1173	296	8	of	of	ADP
ecletica-1173	296	9	proceeded	proceed	VERB
ecletica-1173	296	10	industry	industry	NOUN
ecletica-1173	296	11	mergers	merger	NOUN
ecletica-1173	296	12	,	,	PUNCT
ecletica-1173	296	13	acquisitions	acquisition	NOUN
ecletica-1173	296	14	and	and	CCONJ
ecletica-1173	296	15	yearly	yearly	ADJ
ecletica-1173	296	16	investing	invest	VERB
ecletica-1173	296	17	over	over	ADP
ecletica-1173	296	18	us$	us$	SYM
ecletica-1173	296	19	30	30	NUM
ecletica-1173	296	20	billion	billion	NUM
ecletica-1173	296	21	.	.	PUNCT
ecletica-1173	297	1	some	some	DET
ecletica-1173	297	2	commentators	commentator	NOUN
ecletica-1173	297	3	qualify	qualify	VERB
ecletica-1173	297	4	this	this	DET
ecletica-1173	297	5	declination	declination	NOUN
ecletica-1173	297	6	due	due	ADP
ecletica-1173	297	7	to	to	ADP
ecletica-1173	297	8	organization	organization	NOUN
ecletica-1173	297	9	causes	cause	NOUN
ecletica-1173	297	10	,	,	PUNCT
ecletica-1173	297	11	such	such	ADJ
ecletica-1173	297	12	as	as	ADP
ecletica-1173	297	13	wasteful	wasteful	ADJ
ecletica-1173	297	14	venture	venture	NOUN
ecletica-1173	297	15	administration	administration	NOUN
ecletica-1173	297	16	,	,	PUNCT
ecletica-1173	297	17	expanded	expand	VERB
ecletica-1173	297	18	prerequisites	prerequisite	NOUN
ecletica-1173	297	19	,	,	PUNCT
ecletica-1173	297	20	a	a	DET
ecletica-1173	297	21	decrease	decrease	NOUN
ecletica-1173	297	22	in	in	ADP
ecletica-1173	297	23	clinical	clinical	ADJ
ecletica-1173	297	24	science	science	NOUN
ecletica-1173	297	25	that	that	PRON
ecletica-1173	297	26	bargains	bargain	VERB
ecletica-1173	297	27	with	with	ADP
ecletica-1173	297	28	entirety	entirety	NOUN
ecletica-1173	297	29	living	live	VERB
ecletica-1173	297	30	beings	being	NOUN
ecletica-1173	297	31	,	,	PUNCT
ecletica-1173	297	32	an	an	DET
ecletica-1173	297	33	overemphasis	overemphasis	NOUN
ecletica-1173	297	34	on	on	ADP
ecletica-1173	297	35	technology	technology	NOUN
ecletica-1173	297	36	-	-	PUNCT
ecletica-1173	297	37	driven	drive	VERB
ecletica-1173	297	38	inquire	inquire	NOUN
ecletica-1173	297	39	about	about	ADP
ecletica-1173	297	40	,	,	PUNCT
ecletica-1173	297	41	and	and	CCONJ
ecletica-1173	297	42	a	a	DET
ecletica-1173	297	43	need	need	NOUN
ecletica-1173	297	44	of	of	ADP
ecletica-1173	297	45	eagerness	eagerness	NOUN
ecletica-1173	297	46	to	to	PART
ecletica-1173	297	47	do	do	AUX
ecletica-1173	297	48	so	so	ADV
ecletica-1173	297	49	,	,	PUNCT
ecletica-1173	297	50	center	center	NOUN
ecletica-1173	297	51	on	on	ADP
ecletica-1173	297	52	items	item	NOUN
ecletica-1173	297	53	that	that	PRON
ecletica-1173	297	54	are	be	AUX
ecletica-1173	297	55	not	not	PART
ecletica-1173	297	56	anticipated	anticipate	VERB
ecletica-1173	297	57	to	to	PART
ecletica-1173	297	58	create	create	VERB
ecletica-1173	297	59	deals	deal	NOUN
ecletica-1173	297	60	of	of	ADP
ecletica-1173	297	61	at	at	ADP
ecletica-1173	297	62	slightest	slight	ADJ
ecletica-1173	297	63	us$	us$	SYM
ecletica-1173	297	64	0.5	0.5	NUM
ecletica-1173	297	65	to	to	PART
ecletica-1173	297	66	1.0	1.0	NUM
ecletica-1173	297	67	billion	billion	NUM
ecletica-1173	297	68	per	per	ADP
ecletica-1173	297	69	year	year	NOUN
ecletica-1173	297	70	(	(	PUNCT
ecletica-1173	297	71	drews	drews	PROPN
ecletica-1173	297	72	,	,	PUNCT
ecletica-1173	297	73	2003	2003	NUM
ecletica-1173	297	74	;	;	PUNCT
ecletica-1173	297	75	fojo	fojo	NOUN
ecletica-1173	297	76	,	,	PUNCT
ecletica-1173	297	77	2008	2008	NUM
ecletica-1173	297	78	;	;	PUNCT
ecletica-1173	297	79	gershell	gershell	NOUN
ecletica-1173	297	80	and	and	CCONJ
ecletica-1173	297	81	atkins	atkin	NOUN
ecletica-1173	297	82	,	,	PUNCT
ecletica-1173	297	83	2003	2003	NUM
ecletica-1173	297	84	;	;	PUNCT
ecletica-1173	297	85	kubinyi	kubinyi	PROPN
ecletica-1173	297	86	,	,	PUNCT
ecletica-1173	297	87	2003	2003	NUM
ecletica-1173	297	88	;	;	PUNCT
ecletica-1173	297	89	miska	miska	PROPN
ecletica-1173	297	90	,	,	PUNCT
ecletica-1173	297	91	2003	2003	NUM
ecletica-1173	297	92	)	)	PUNCT
ecletica-1173	297	93	.	.	PUNCT
ecletica-1173	298	1	furthermore	furthermore	ADV
ecletica-1173	298	2	,	,	PUNCT
ecletica-1173	298	3	these	these	DET
ecletica-1173	298	4	results	result	NOUN
ecletica-1173	298	5	show	show	VERB
ecletica-1173	298	6	that	that	SCONJ
ecletica-1173	298	7	http://revista.iq.unesp.br/ojs/index.php/ecletica/index	http://revista.iq.unesp.br/ojs/index.php/ecletica/index	NOUN
ecletica-1173	298	8	https://doi.org/10.26850/1678-4618eqj.v46.3.2021.p17-32	https://doi.org/10.26850/1678-4618eqj.v46.3.2021.p17-32	PROPN
ecletica-1173	298	9	review	review	NOUN
ecletica-1173	298	10	article	article	NOUN
ecletica-1173	298	11	iq.unesp.br/ecletica	iq.unesp.br/ecletica	PROPN
ecletica-1173	298	12	25	25	NUM
ecletica-1173	298	13	eclética	eclética	PROPN
ecletica-1173	298	14	química	química	PROPN
ecletica-1173	298	15	journal	journal	PROPN
ecletica-1173	298	16	,	,	PUNCT
ecletica-1173	298	17	vol	vol	NOUN
ecletica-1173	298	18	.	.	PROPN
ecletica-1173	298	19	46	46	NUM
ecletica-1173	298	20	,	,	PUNCT
ecletica-1173	298	21	n.	n.	NOUN
ecletica-1173	298	22	3	3	NUM
ecletica-1173	298	23	,	,	PUNCT
ecletica-1173	298	24	2021	2021	NUM
ecletica-1173	298	25	,	,	PUNCT
ecletica-1173	298	26	17	17	NUM
ecletica-1173	298	27	-	-	SYM
ecletica-1173	298	28	32	32	NUM
ecletica-1173	298	29	issn	issn	NOUN
ecletica-1173	298	30	:	:	PUNCT
ecletica-1173	298	31	1678	1678	NUM
ecletica-1173	298	32	-	-	SYM
ecletica-1173	298	33	4618	4618	NUM
ecletica-1173	298	34	doi	doi	NOUN
ecletica-1173	298	35	:	:	PUNCT
ecletica-1173	298	36	10.26850/1678	10.26850/1678	NUM
ecletica-1173	298	37	-	-	SYM
ecletica-1173	298	38	4618eqj.v46.3.2021.p17	4618eqj.v46.3.2021.p17	NOUN
ecletica-1173	298	39	-	-	PUNCT
ecletica-1173	298	40	32	32	NUM
ecletica-1173	298	41	methodologies	methodology	NOUN
ecletica-1173	298	42	based	base	VERB
ecletica-1173	298	43	on	on	ADP
ecletica-1173	298	44	tall	tall	ADJ
ecletica-1173	298	45	throughput	throughput	NOUN
ecletica-1173	298	46	screening	screening	NOUN
ecletica-1173	298	47	,	,	PUNCT
ecletica-1173	298	48	combinatorial	combinatorial	ADJ
ecletica-1173	298	49	chemistry	chemistry	NOUN
ecletica-1173	298	50	,	,	PUNCT
ecletica-1173	298	51	genomics	genomics	NOUN
ecletica-1173	298	52	,	,	PUNCT
ecletica-1173	298	53	proteomics	proteomic	NOUN
ecletica-1173	298	54	,	,	PUNCT
ecletica-1173	298	55	and	and	CCONJ
ecletica-1173	298	56	bioinformatics	bioinformatic	NOUN
ecletica-1173	298	57	are	be	AUX
ecletica-1173	298	58	not	not	PART
ecletica-1173	298	59	bringing	bring	VERB
ecletica-1173	298	60	the	the	DET
ecletica-1173	298	61	modern	modern	ADJ
ecletica-1173	298	62	conquests	conquest	NOUN
ecletica-1173	298	63	that	that	PRON
ecletica-1173	298	64	were	be	AUX
ecletica-1173	298	65	predicted	predict	VERB
ecletica-1173	298	66	(	(	PUNCT
ecletica-1173	298	67	glassman	glassman	NOUN
ecletica-1173	298	68	and	and	CCONJ
ecletica-1173	298	69	sun	sun	PROPN
ecletica-1173	298	70	,	,	PUNCT
ecletica-1173	298	71	2004	2004	NUM
ecletica-1173	298	72	;	;	PUNCT
ecletica-1173	298	73	kubinyi	kubinyi	PROPN
ecletica-1173	298	74	,	,	PUNCT
ecletica-1173	298	75	2003	2003	NUM
ecletica-1173	298	76	;	;	PUNCT
ecletica-1173	298	77	miska	miska	PROPN
ecletica-1173	298	78	,	,	PUNCT
ecletica-1173	298	79	2003	2003	NUM
ecletica-1173	298	80	)	)	PUNCT
ecletica-1173	298	81	.	.	PUNCT
ecletica-1173	299	1	information	information	NOUN
ecletica-1173	299	2	about	about	ADP
ecletica-1173	299	3	human	human	ADJ
ecletica-1173	299	4	genome	genome	NOUN
ecletica-1173	299	5	arrangements	arrangement	NOUN
ecletica-1173	299	6	and	and	CCONJ
ecletica-1173	299	7	different	different	ADJ
ecletica-1173	299	8	pathogens	pathogen	NOUN
ecletica-1173	299	9	led	lead	VERB
ecletica-1173	299	10	to	to	ADP
ecletica-1173	299	11	a	a	DET
ecletica-1173	299	12	set	set	ADJ
ecletica-1173	299	13	number	number	NOUN
ecletica-1173	299	14	of	of	ADP
ecletica-1173	299	15	modern	modern	ADJ
ecletica-1173	299	16	drug	drug	NOUN
ecletica-1173	299	17	targets	target	NOUN
ecletica-1173	299	18	(	(	PUNCT
ecletica-1173	299	19	drews	drew	NOUN
ecletica-1173	299	20	,	,	PUNCT
ecletica-1173	299	21	2003	2003	NUM
ecletica-1173	299	22	)	)	PUNCT
ecletica-1173	299	23	.	.	PUNCT
ecletica-1173	300	1	in	in	ADP
ecletica-1173	300	2	addition	addition	NOUN
ecletica-1173	300	3	,	,	PUNCT
ecletica-1173	300	4	a	a	DET
ecletica-1173	300	5	few	few	ADJ
ecletica-1173	300	6	biotechnology	biotechnology	NOUN
ecletica-1173	300	7	enterprises	enterprise	NOUN
ecletica-1173	300	8	fizzled	fizzle	VERB
ecletica-1173	300	9	to	to	PART
ecletica-1173	300	10	correspond	correspond	VERB
ecletica-1173	300	11	to	to	ADP
ecletica-1173	300	12	the	the	DET
ecletica-1173	300	13	perspectives	perspective	NOUN
ecletica-1173	300	14	in	in	ADP
ecletica-1173	300	15	order	order	NOUN
ecletica-1173	300	16	to	to	PART
ecletica-1173	300	17	establish	establish	VERB
ecletica-1173	300	18	quality	quality	NOUN
ecletica-1173	300	19	treatment	treatment	NOUN
ecletica-1173	300	20	,	,	PUNCT
ecletica-1173	300	21	investigating	investigate	VERB
ecletica-1173	300	22	antisense	antisense	NOUN
ecletica-1173	300	23	innovation	innovation	NOUN
ecletica-1173	300	24	and	and	CCONJ
ecletica-1173	300	25	cancer	cancer	NOUN
ecletica-1173	300	26	immunizations	immunization	NOUN
ecletica-1173	300	27	.	.	PUNCT
ecletica-1173	301	1	a	a	DET
ecletica-1173	301	2	common	common	ADJ
ecletica-1173	301	3	issue	issue	NOUN
ecletica-1173	301	4	with	with	ADP
ecletica-1173	301	5	numerous	numerous	ADJ
ecletica-1173	301	6	of	of	ADP
ecletica-1173	301	7	these	these	DET
ecletica-1173	301	8	advancements	advancement	NOUN
ecletica-1173	301	9	is	be	AUX
ecletica-1173	301	10	that	that	SCONJ
ecletica-1173	301	11	the	the	DET
ecletica-1173	301	12	potential	potential	NOUN
ecletica-1173	301	13	for	for	ADP
ecletica-1173	301	14	dangers	danger	NOUN
ecletica-1173	301	15	and	and	CCONJ
ecletica-1173	301	16	undesirable	undesirable	ADJ
ecletica-1173	301	17	side	side	NOUN
ecletica-1173	301	18	impacts	impact	NOUN
ecletica-1173	301	19	tend	tend	VERB
ecletica-1173	301	20	to	to	PART
ecletica-1173	301	21	be	be	AUX
ecletica-1173	301	22	ignored	ignore	VERB
ecletica-1173	301	23	,	,	PUNCT
ecletica-1173	301	24	as	as	SCONJ
ecletica-1173	301	25	was	be	AUX
ecletica-1173	301	26	the	the	DET
ecletica-1173	301	27	case	case	NOUN
ecletica-1173	301	28	with	with	ADP
ecletica-1173	301	29	gene	gene	NOUN
ecletica-1173	301	30	therapy	therapy	NOUN
ecletica-1173	301	31	(	(	PUNCT
ecletica-1173	301	32	glassman	glassman	NOUN
ecletica-1173	301	33	and	and	CCONJ
ecletica-1173	301	34	sun	sun	PROPN
ecletica-1173	301	35	,	,	PUNCT
ecletica-1173	301	36	2004	2004	NUM
ecletica-1173	301	37	)	)	PUNCT
ecletica-1173	301	38	.	.	PUNCT
ecletica-1173	302	1	however	however	ADV
ecletica-1173	302	2	,	,	PUNCT
ecletica-1173	302	3	there	there	PRON
ecletica-1173	302	4	is	be	VERB
ecletica-1173	302	5	a	a	DET
ecletica-1173	302	6	probable	probable	ADJ
ecletica-1173	302	7	reason	reason	NOUN
ecletica-1173	302	8	for	for	ADP
ecletica-1173	302	9	these	these	DET
ecletica-1173	302	10	disappointments	disappointment	NOUN
ecletica-1173	302	11	:	:	PUNCT
ecletica-1173	302	12	most	most	ADJ
ecletica-1173	302	13	of	of	ADP
ecletica-1173	302	14	these	these	DET
ecletica-1173	302	15	approaches	approach	NOUN
ecletica-1173	302	16	have	have	AUX
ecletica-1173	302	17	been	be	AUX
ecletica-1173	302	18	guided	guide	VERB
ecletica-1173	302	19	by	by	ADP
ecletica-1173	302	20	supreme	supreme	ADJ
ecletica-1173	302	21	reductionism	reductionism	NOUN
ecletica-1173	302	22	.	.	PUNCT
ecletica-1173	303	1	as	as	ADP
ecletica-1173	303	2	a	a	DET
ecletica-1173	303	3	result	result	NOUN
ecletica-1173	303	4	,	,	PUNCT
ecletica-1173	303	5	the	the	DET
ecletica-1173	303	6	complexity	complexity	NOUN
ecletica-1173	303	7	of	of	ADP
ecletica-1173	303	8	organic	organic	ADJ
ecletica-1173	303	9	frameworks	framework	NOUN
ecletica-1173	303	10	,	,	PUNCT
ecletica-1173	303	11	whole	whole	ADJ
ecletica-1173	303	12	life	life	NOUN
ecletica-1173	303	13	forms	form	NOUN
ecletica-1173	303	14	and	and	CCONJ
ecletica-1173	303	15	patients	patient	NOUN
ecletica-1173	303	16	tends	tend	VERB
ecletica-1173	303	17	to	to	PART
ecletica-1173	303	18	be	be	AUX
ecletica-1173	303	19	underestimated	underestimate	VERB
ecletica-1173	303	20	(	(	PUNCT
ecletica-1173	303	21	horrobin	horrobin	NOUN
ecletica-1173	303	22	,	,	PUNCT
ecletica-1173	303	23	2001	2001	NUM
ecletica-1173	303	24	)	)	PUNCT
ecletica-1173	303	25	.	.	PUNCT
ecletica-1173	304	1	illnesses	illness	NOUN
ecletica-1173	304	2	results	result	VERB
ecletica-1173	304	3	from	from	ADP
ecletica-1173	304	4	the	the	DET
ecletica-1173	304	5	interaction	interaction	NOUN
ecletica-1173	304	6	of	of	ADP
ecletica-1173	304	7	numerous	numerous	ADJ
ecletica-1173	304	8	genes	gene	NOUN
ecletica-1173	304	9	and	and	CCONJ
ecletica-1173	304	10	sometimes	sometimes	ADV
ecletica-1173	304	11	it	it	PRON
ecletica-1173	304	12	is	be	AUX
ecletica-1173	304	13	conceivable	conceivable	ADJ
ecletica-1173	304	14	to	to	PART
ecletica-1173	304	15	know	know	VERB
ecletica-1173	304	16	all	all	DET
ecletica-1173	304	17	the	the	DET
ecletica-1173	304	18	genes	gene	NOUN
ecletica-1173	304	19	and	and	CCONJ
ecletica-1173	304	20	hereditary	hereditary	NOUN
ecletica-1173	304	21	included	include	VERB
ecletica-1173	304	22	in	in	ADP
ecletica-1173	304	23	a	a	DET
ecletica-1173	304	24	specific	specific	ADJ
ecletica-1173	304	25	biological	biological	ADJ
ecletica-1173	304	26	function	function	NOUN
ecletica-1173	304	27	.	.	PUNCT
ecletica-1173	305	1	another	another	DET
ecletica-1173	305	2	field	field	NOUN
ecletica-1173	305	3	of	of	ADP
ecletica-1173	305	4	biomedical	biomedical	ADJ
ecletica-1173	305	5	science	science	NOUN
ecletica-1173	305	6	strongly	strongly	ADV
ecletica-1173	305	7	influenced	influence	VERB
ecletica-1173	305	8	by	by	ADP
ecletica-1173	305	9	reductionist	reductionist	ADJ
ecletica-1173	305	10	theory	theory	NOUN
ecletica-1173	305	11	is	be	AUX
ecletica-1173	305	12	the	the	DET
ecletica-1173	305	13	so	so	ADV
ecletica-1173	305	14	-	-	PUNCT
ecletica-1173	305	15	called	call	VERB
ecletica-1173	305	16	vaccine	vaccine	NOUN
ecletica-1173	305	17	design	design	NOUN
ecletica-1173	305	18	,	,	PUNCT
ecletica-1173	305	19	which	which	PRON
ecletica-1173	305	20	is	be	AUX
ecletica-1173	305	21	based	base	VERB
ecletica-1173	305	22	on	on	ADP
ecletica-1173	305	23	the	the	DET
ecletica-1173	305	24	premise	premise	NOUN
ecletica-1173	305	25	that	that	SCONJ
ecletica-1173	305	26	the	the	DET
ecletica-1173	305	27	concepts	concept	NOUN
ecletica-1173	305	28	of	of	ADP
ecletica-1173	305	29	drug	drug	NOUN
ecletica-1173	305	30	design	design	NOUN
ecletica-1173	305	31	based	base	VERB
ecletica-1173	305	32	on	on	ADP
ecletica-1173	305	33	molecular	molecular	ADJ
ecletica-1173	305	34	structure	structure	NOUN
ecletica-1173	305	35	can	can	AUX
ecletica-1173	305	36	be	be	AUX
ecletica-1173	305	37	applied	apply	VERB
ecletica-1173	305	38	to	to	ADP
ecletica-1173	305	39	vaccines	vaccine	NOUN
ecletica-1173	305	40	(	(	PUNCT
ecletica-1173	305	41	van	van	PROPN
ecletica-1173	305	42	regenmortel	regenmortel	NOUN
ecletica-1173	305	43	,	,	PUNCT
ecletica-1173	305	44	2001	2001	NUM
ecletica-1173	305	45	;	;	PUNCT
ecletica-1173	305	46	2021	2021	NUM
ecletica-1173	305	47	)	)	PUNCT
ecletica-1173	305	48	.	.	PUNCT
ecletica-1173	306	1	however	however	ADV
ecletica-1173	306	2	,	,	PUNCT
ecletica-1173	306	3	this	this	DET
ecletica-1173	306	4	approach	approach	NOUN
ecletica-1173	306	5	neglects	neglect	VERB
ecletica-1173	306	6	that	that	SCONJ
ecletica-1173	306	7	the	the	DET
ecletica-1173	306	8	relationship	relationship	NOUN
ecletica-1173	306	9	between	between	ADP
ecletica-1173	306	10	a	a	DET
ecletica-1173	306	11	drug	drug	NOUN
ecletica-1173	306	12	and	and	CCONJ
ecletica-1173	306	13	its	its	PRON
ecletica-1173	306	14	receptor	receptor	NOUN
ecletica-1173	306	15	or	or	CCONJ
ecletica-1173	306	16	molecular	molecular	ADJ
ecletica-1173	306	17	target	target	NOUN
ecletica-1173	306	18	is	be	AUX
ecletica-1173	306	19	exceptionally	exceptionally	ADV
ecletica-1173	306	20	particular	particular	ADJ
ecletica-1173	306	21	,	,	PUNCT
ecletica-1173	306	22	whereas	whereas	SCONJ
ecletica-1173	306	23	the	the	DET
ecletica-1173	306	24	relationship	relationship	NOUN
ecletica-1173	306	25	between	between	ADP
ecletica-1173	306	26	an	an	DET
ecletica-1173	306	27	antigen	antigen	NOUN
ecletica-1173	306	28	and	and	CCONJ
ecletica-1173	306	29	a	a	DET
ecletica-1173	306	30	counter	counter	ADJ
ecletica-1173	306	31	acting	act	VERB
ecletica-1173	306	32	agent	agent	NOUN
ecletica-1173	306	33	is	be	AUX
ecletica-1173	306	34	much	much	ADV
ecletica-1173	306	35	less	less	ADV
ecletica-1173	306	36	limited	limited	ADJ
ecletica-1173	306	37	.	.	PUNCT
ecletica-1173	307	1	the	the	DET
ecletica-1173	307	2	binding	bind	VERB
ecletica-1173	307	3	site	site	NOUN
ecletica-1173	307	4	of	of	ADP
ecletica-1173	307	5	an	an	DET
ecletica-1173	307	6	immunoglobulin	immunoglobulin	NOUN
ecletica-1173	307	7	molecule	molecule	NOUN
ecletica-1173	307	8	comprises	comprise	VERB
ecletica-1173	307	9	approximately	approximately	ADV
ecletica-1173	307	10	50	50	NUM
ecletica-1173	307	11	hypervariable	hypervariable	ADJ
ecletica-1173	307	12	residues	residue	NOUN
ecletica-1173	307	13	that	that	PRON
ecletica-1173	307	14	together	together	ADV
ecletica-1173	307	15	constitute	constitute	VERB
ecletica-1173	307	16	the	the	DET
ecletica-1173	307	17	complementarity	complementarity	NOUN
ecletica-1173	307	18	determining	determine	VERB
ecletica-1173	307	19	regions	region	NOUN
ecletica-1173	307	20	(	(	PUNCT
ecletica-1173	307	21	cdrs	cdr	NOUN
ecletica-1173	307	22	)	)	PUNCT
ecletica-1173	307	23	.	.	PUNCT
ecletica-1173	308	1	hypervariable	hypervariable	ADJ
ecletica-1173	308	2	residues	residue	NOUN
ecletica-1173	308	3	together	together	ADV
ecletica-1173	308	4	make	make	VERB
ecletica-1173	308	5	the	the	DET
ecletica-1173	308	6	cdrs	cdr	NOUN
ecletica-1173	308	7	.	.	PUNCT
ecletica-1173	309	1	in	in	ADP
ecletica-1173	309	2	general	general	ADJ
ecletica-1173	309	3	,	,	PUNCT
ecletica-1173	309	4	around	around	ADP
ecletica-1173	309	5	10–15	10–15	NUM
ecletica-1173	309	6	of	of	ADP
ecletica-1173	309	7	these	these	DET
ecletica-1173	309	8	residues	residue	NOUN
ecletica-1173	309	9	have	have	VERB
ecletica-1173	309	10	an	an	DET
ecletica-1173	309	11	interest	interest	NOUN
ecletica-1173	309	12	in	in	ADP
ecletica-1173	309	13	interaction	interaction	NOUN
ecletica-1173	309	14	with	with	ADP
ecletica-1173	309	15	a	a	DET
ecletica-1173	309	16	specific	specific	ADJ
ecletica-1173	309	17	epitope	epitope	NOUN
ecletica-1173	309	18	,	,	PUNCT
ecletica-1173	309	19	but	but	CCONJ
ecletica-1173	309	20	the	the	DET
ecletica-1173	309	21	total	total	ADJ
ecletica-1173	309	22	complement	complement	NOUN
ecletica-1173	309	23	of	of	ADP
ecletica-1173	309	24	all	all	DET
ecletica-1173	309	25	50	50	NUM
ecletica-1173	309	26	hypervariable	hypervariable	ADJ
ecletica-1173	309	27	residues	residue	NOUN
ecletica-1173	309	28	does	do	AUX
ecletica-1173	309	29	not	not	PART
ecletica-1173	309	30	constitute	constitute	VERB
ecletica-1173	309	31	a	a	DET
ecletica-1173	309	32	real	real	ADJ
ecletica-1173	309	33	binding	bind	VERB
ecletica-1173	309	34	site	site	NOUN
ecletica-1173	309	35	for	for	ADP
ecletica-1173	309	36	any	any	DET
ecletica-1173	309	37	epitope	epitope	NOUN
ecletica-1173	309	38	.	.	PUNCT
ecletica-1173	310	1	this	this	PRON
ecletica-1173	310	2	implies	imply	VERB
ecletica-1173	310	3	that	that	SCONJ
ecletica-1173	310	4	approximately	approximately	ADV
ecletica-1173	310	5	35	35	NUM
ecletica-1173	310	6	of	of	ADP
ecletica-1173	310	7	the	the	DET
ecletica-1173	310	8	cdrs	cdr	NOUN
ecletica-1173	310	9	residues	residue	NOUN
ecletica-1173	310	10	can	can	AUX
ecletica-1173	310	11	possibly	possibly	ADV
ecletica-1173	310	12	bind	bind	VERB
ecletica-1173	310	13	to	to	ADP
ecletica-1173	310	14	other	other	ADJ
ecletica-1173	310	15	epitopes	epitope	NOUN
ecletica-1173	310	16	that	that	PRON
ecletica-1173	310	17	are	be	AUX
ecletica-1173	310	18	small	small	ADJ
ecletica-1173	310	19	or	or	CCONJ
ecletica-1173	310	20	no	no	DET
ecletica-1173	310	21	likeness	likeness	NOUN
ecletica-1173	310	22	to	to	ADP
ecletica-1173	310	23	the	the	DET
ecletica-1173	310	24	previous	previous	ADJ
ecletica-1173	310	25	.	.	PUNCT
ecletica-1173	311	1	this	this	DET
ecletica-1173	311	2	complexity	complexity	NOUN
ecletica-1173	311	3	clarifies	clarify	VERB
ecletica-1173	311	4	the	the	DET
ecletica-1173	311	5	broad	broad	ADJ
ecletica-1173	311	6	multi	multi	ADJ
ecletica-1173	311	7	-	-	NOUN
ecletica-1173	311	8	specificity	specificity	NOUN
ecletica-1173	311	9	of	of	ADP
ecletica-1173	311	10	immunoglobulins	immunoglobulin	NOUN
ecletica-1173	311	11	and	and	CCONJ
ecletica-1173	311	12	the	the	DET
ecletica-1173	311	13	numerous	numerous	ADJ
ecletica-1173	311	14	distinctive	distinctive	ADJ
ecletica-1173	311	15	paratopes	paratope	NOUN
ecletica-1173	311	16	or	or	CCONJ
ecletica-1173	311	17	bind	bind	VERB
ecletica-1173	311	18	sites	site	NOUN
ecletica-1173	311	19	on	on	ADP
ecletica-1173	311	20	each	each	DET
ecletica-1173	311	21	molecule	molecule	NOUN
ecletica-1173	311	22	.	.	PUNCT
ecletica-1173	312	1	the	the	DET
ecletica-1173	312	2	capacity	capacity	NOUN
ecletica-1173	312	3	of	of	ADP
ecletica-1173	312	4	an	an	DET
ecletica-1173	312	5	immunoglobulin	immunoglobulin	NOUN
ecletica-1173	312	6	molecule	molecule	NOUN
ecletica-1173	312	7	to	to	PART
ecletica-1173	312	8	bind	bind	VERB
ecletica-1173	312	9	to	to	ADP
ecletica-1173	312	10	different	different	ADJ
ecletica-1173	312	11	antigenic	antigenic	ADJ
ecletica-1173	312	12	structures	structure	NOUN
ecletica-1173	312	13	is	be	AUX
ecletica-1173	312	14	improved	improve	VERB
ecletica-1173	312	15	by	by	ADP
ecletica-1173	312	16	the	the	DET
ecletica-1173	312	17	impressive	impressive	ADJ
ecletica-1173	312	18	adaptability	adaptability	NOUN
ecletica-1173	312	19	of	of	ADP
ecletica-1173	312	20	cdrs	cdr	NOUN
ecletica-1173	312	21	.	.	PUNCT
ecletica-1173	313	1	the	the	DET
ecletica-1173	313	2	molecule	molecule	NOUN
ecletica-1173	313	3	of	of	ADP
ecletica-1173	313	4	immunoglobulin	immunoglobulin	NOUN
ecletica-1173	313	5	has	have	VERB
ecletica-1173	313	6	different	different	ADJ
ecletica-1173	313	7	conformations	conformation	NOUN
ecletica-1173	313	8	with	with	ADP
ecletica-1173	313	9	several	several	ADJ
ecletica-1173	313	10	binding	bind	VERB
ecletica-1173	313	11	sites	site	NOUN
ecletica-1173	313	12	(	(	PUNCT
ecletica-1173	313	13	bosshard	bosshard	NOUN
ecletica-1173	313	14	,	,	PUNCT
ecletica-1173	313	15	2001	2001	NUM
ecletica-1173	313	16	;	;	PUNCT
ecletica-1173	313	17	goh	goh	PROPN
ecletica-1173	313	18	et	et	PROPN
ecletica-1173	313	19	al	al	PROPN
ecletica-1173	313	20	.	.	PROPN
ecletica-1173	313	21	,	,	PUNCT
ecletica-1173	313	22	2004	2004	NUM
ecletica-1173	313	23	;	;	PUNCT
ecletica-1173	313	24	james	james	PROPN
ecletica-1173	313	25	et	et	PROPN
ecletica-1173	313	26	al	al	PROPN
ecletica-1173	313	27	.	.	PROPN
ecletica-1173	313	28	,	,	PUNCT
ecletica-1173	313	29	2003	2003	NUM
ecletica-1173	313	30	)	)	PUNCT
ecletica-1173	313	31	.	.	PUNCT
ecletica-1173	314	1	in	in	ADP
ecletica-1173	314	2	in	in	ADP
ecletica-1173	314	3	the	the	DET
ecletica-1173	314	4	2000s	2000s	NUM
ecletica-1173	314	5	,	,	PUNCT
ecletica-1173	314	6	rational	rational	ADJ
ecletica-1173	314	7	drug	drug	NOUN
ecletica-1173	314	8	design	design	NOUN
ecletica-1173	314	9	has	have	AUX
ecletica-1173	314	10	become	become	VERB
ecletica-1173	314	11	a	a	DET
ecletica-1173	314	12	necessity	necessity	NOUN
ecletica-1173	314	13	in	in	ADP
ecletica-1173	314	14	the	the	DET
ecletica-1173	314	15	advancement	advancement	NOUN
ecletica-1173	314	16	of	of	ADP
ecletica-1173	314	17	antibody	antibody	NOUN
ecletica-1173	314	18	research	research	NOUN
ecletica-1173	314	19	contradicting	contradict	VERB
ecletica-1173	314	20	observational	observational	ADJ
ecletica-1173	314	21	data	datum	NOUN
ecletica-1173	314	22	(	(	PUNCT
ecletica-1173	314	23	van	van	PROPN
ecletica-1173	314	24	regenmortel	regenmortel	NOUN
ecletica-1173	314	25	,	,	PUNCT
ecletica-1173	314	26	2000	2000	NUM
ecletica-1173	314	27	)	)	PUNCT
ecletica-1173	314	28	.	.	PUNCT
ecletica-1173	315	1	the	the	DET
ecletica-1173	315	2	term	term	NOUN
ecletica-1173	315	3	rational	rational	ADJ
ecletica-1173	315	4	drug	drug	NOUN
ecletica-1173	315	5	design	design	NOUN
ecletica-1173	315	6	suggests	suggest	VERB
ecletica-1173	315	7	that	that	SCONJ
ecletica-1173	315	8	this	this	DET
ecletica-1173	315	9	investigation	investigation	NOUN
ecletica-1173	315	10	uses	use	VERB
ecletica-1173	315	11	molecular	molecular	ADJ
ecletica-1173	315	12	information	information	NOUN
ecletica-1173	315	13	and	and	CCONJ
ecletica-1173	315	14	structural	structural	ADJ
ecletica-1173	315	15	knowledge	knowledge	NOUN
ecletica-1173	315	16	,	,	PUNCT
ecletica-1173	315	17	whereas	whereas	SCONJ
ecletica-1173	315	18	the	the	DET
ecletica-1173	315	19	term	term	NOUN
ecletica-1173	315	20	design	design	NOUN
ecletica-1173	315	21	shows	show	VERB
ecletica-1173	315	22	that	that	SCONJ
ecletica-1173	315	23	the	the	DET
ecletica-1173	315	24	developed	develop	VERB
ecletica-1173	315	25	products	product	NOUN
ecletica-1173	315	26	are	be	AUX
ecletica-1173	315	27	predictable	predictable	ADJ
ecletica-1173	315	28	.	.	PUNCT
ecletica-1173	316	1	rational	rational	ADJ
ecletica-1173	316	2	drug	drug	NOUN
ecletica-1173	316	3	design	design	NOUN
ecletica-1173	316	4	is	be	AUX
ecletica-1173	316	5	considered	consider	VERB
ecletica-1173	316	6	the	the	DET
ecletica-1173	316	7	more	more	ADV
ecletica-1173	316	8	logical	logical	ADJ
ecletica-1173	316	9	approach	approach	NOUN
ecletica-1173	316	10	than	than	ADP
ecletica-1173	316	11	experimental	experimental	ADJ
ecletica-1173	316	12	“	"	PUNCT
ecletica-1173	316	13	trial	trial	NOUN
ecletica-1173	316	14	-	-	PUNCT
ecletica-1173	316	15	and	and	CCONJ
ecletica-1173	316	16	-	-	PUNCT
ecletica-1173	316	17	error	error	NOUN
ecletica-1173	316	18	”	"	PUNCT
ecletica-1173	316	19	screening	screening	NOUN
ecletica-1173	316	20	and	and	CCONJ
ecletica-1173	316	21	molecular	molecular	ADJ
ecletica-1173	316	22	selection	selection	NOUN
ecletica-1173	316	23	.	.	PUNCT
ecletica-1173	317	1	the	the	DET
ecletica-1173	317	2	conviction	conviction	NOUN
ecletica-1173	317	3	that	that	SCONJ
ecletica-1173	317	4	a	a	DET
ecletica-1173	317	5	molecular	molecular	ADJ
ecletica-1173	317	6	design	design	NOUN
ecletica-1173	317	7	plan	plan	NOUN
ecletica-1173	317	8	will	will	AUX
ecletica-1173	317	9	be	be	AUX
ecletica-1173	317	10	effective	effective	ADJ
ecletica-1173	317	11	for	for	ADP
ecletica-1173	317	12	the	the	DET
ecletica-1173	317	13	improvement	improvement	NOUN
ecletica-1173	317	14	of	of	ADP
ecletica-1173	317	15	unused	unused	ADJ
ecletica-1173	317	16	antibodies	antibody	NOUN
ecletica-1173	317	17	is	be	AUX
ecletica-1173	317	18	ordinary	ordinary	ADJ
ecletica-1173	317	19	of	of	ADP
ecletica-1173	317	20	the	the	DET
ecletica-1173	317	21	reductionist	reductionist	ADJ
ecletica-1173	317	22	approach	approach	NOUN
ecletica-1173	317	23	.	.	PUNCT
ecletica-1173	318	1	ontological	ontological	ADJ
ecletica-1173	318	2	reductionism	reductionism	NOUN
ecletica-1173	318	3	expects	expect	VERB
ecletica-1173	318	4	that	that	SCONJ
ecletica-1173	318	5	a	a	DET
ecletica-1173	318	6	biological	biological	ADJ
ecletica-1173	318	7	phenomenon	phenomenon	NOUN
ecletica-1173	318	8	can	can	AUX
ecletica-1173	318	9	be	be	AUX
ecletica-1173	318	10	decreased	decrease	VERB
ecletica-1173	318	11	to	to	ADP
ecletica-1173	318	12	the	the	DET
ecletica-1173	318	13	chemistry	chemistry	NOUN
ecletica-1173	318	14	level	level	NOUN
ecletica-1173	318	15	.	.	PUNCT
ecletica-1173	319	1	however	however	ADV
ecletica-1173	319	2	,	,	PUNCT
ecletica-1173	319	3	there	there	PRON
ecletica-1173	319	4	are	be	VERB
ecletica-1173	319	5	numerous	numerous	ADJ
ecletica-1173	319	6	reasons	reason	NOUN
ecletica-1173	319	7	that	that	PRON
ecletica-1173	319	8	show	show	VERB
ecletica-1173	319	9	that	that	SCONJ
ecletica-1173	319	10	reductionist	reductionist	ADJ
ecletica-1173	319	11	approaches	approach	NOUN
ecletica-1173	319	12	to	to	PART
ecletica-1173	319	13	antibody	antibody	NOUN
ecletica-1173	319	14	advancement	advancement	NOUN
ecletica-1173	319	15	are	be	AUX
ecletica-1173	319	16	impossible	impossible	ADJ
ecletica-1173	319	17	to	to	PART
ecletica-1173	319	18	succeed	succeed	VERB
ecletica-1173	319	19	.	.	PUNCT
ecletica-1173	320	1	first	first	ADV
ecletica-1173	320	2	,	,	PUNCT
ecletica-1173	320	3	the	the	DET
ecletica-1173	320	4	antigenic	antigenic	ADJ
ecletica-1173	320	5	determinants	determinant	NOUN
ecletica-1173	320	6	or	or	CCONJ
ecletica-1173	320	7	epitopes	epitope	NOUN
ecletica-1173	320	8	of	of	ADP
ecletica-1173	320	9	an	an	DET
ecletica-1173	320	10	infectious	infectious	ADJ
ecletica-1173	320	11	agent	agent	NOUN
ecletica-1173	320	12	are	be	AUX
ecletica-1173	320	13	rising	rise	VERB
ecletica-1173	320	14	substances	substance	NOUN
ecletica-1173	320	15	that	that	PRON
ecletica-1173	320	16	are	be	AUX
ecletica-1173	320	17	characterized	characterize	VERB
ecletica-1173	320	18	by	by	ADP
ecletica-1173	320	19	their	their	PRON
ecletica-1173	320	20	particular	particular	ADJ
ecletica-1173	320	21	antibody	antibody	NOUN
ecletica-1173	320	22	partners	partner	NOUN
ecletica-1173	320	23	and	and	CCONJ
ecletica-1173	320	24	exist	exist	VERB
ecletica-1173	320	25	as	as	SCONJ
ecletica-1173	320	26	it	it	PRON
ecletica-1173	320	27	were	be	AUX
ecletica-1173	320	28	within	within	ADP
ecletica-1173	320	29	the	the	DET
ecletica-1173	320	30	setting	setting	NOUN
ecletica-1173	320	31	of	of	ADP
ecletica-1173	320	32	the	the	DET
ecletica-1173	320	33	immune	immune	ADJ
ecletica-1173	320	34	system	system	NOUN
ecletica-1173	320	35	.	.	PUNCT
ecletica-1173	321	1	epitopes	epitope	NOUN
ecletica-1173	321	2	and	and	CCONJ
ecletica-1173	321	3	paratopes	paratope	NOUN
ecletica-1173	321	4	are	be	AUX
ecletica-1173	321	5	not	not	PART
ecletica-1173	321	6	intrinsic	intrinsic	ADJ
ecletica-1173	321	7	characteristics	characteristic	NOUN
ecletica-1173	321	8	of	of	ADP
ecletica-1173	321	9	an	an	DET
ecletica-1173	321	10	antigen	antigen	NOUN
ecletica-1173	321	11	.	.	PUNCT
ecletica-1173	322	1	immunoglobulin	immunoglobulin	NOUN
ecletica-1173	322	2	individually	individually	ADV
ecletica-1173	322	3	can	can	AUX
ecletica-1173	322	4	not	not	PART
ecletica-1173	322	5	be	be	AUX
ecletica-1173	322	6	recognized	recognize	VERB
ecletica-1173	322	7	autonomously	autonomously	ADV
ecletica-1173	322	8	by	by	ADP
ecletica-1173	322	9	a	a	DET
ecletica-1173	322	10	binding	bind	VERB
ecletica-1173	322	11	reaction	reaction	NOUN
ecletica-1173	322	12	.	.	PUNCT
ecletica-1173	323	1	second	second	ADJ
ecletica-1173	323	2	,	,	PUNCT
ecletica-1173	323	3	the	the	DET
ecletica-1173	323	4	idea	idea	NOUN
ecletica-1173	323	5	behind	behind	ADP
ecletica-1173	323	6	the	the	DET
ecletica-1173	323	7	antibodies	antibody	NOUN
ecletica-1173	323	8	that	that	PRON
ecletica-1173	323	9	essentially	essentially	ADV
ecletica-1173	323	10	bind	bind	VERB
ecletica-1173	323	11	to	to	ADP
ecletica-1173	323	12	the	the	DET
ecletica-1173	323	13	pathogen	pathogen	NOUN
ecletica-1173	323	14	have	have	VERB
ecletica-1173	323	15	small	small	ADJ
ecletica-1173	323	16	consideration	consideration	NOUN
ecletica-1173	323	17	in	in	ADP
ecletica-1173	323	18	immunization	immunization	NOUN
ecletica-1173	323	19	advancement	advancement	NOUN
ecletica-1173	323	20	.	.	PUNCT
ecletica-1173	324	1	antibodies	antibodie	VERB
ecletica-1173	324	2	that	that	PRON
ecletica-1173	324	3	have	have	VERB
ecletica-1173	324	4	a	a	DET
ecletica-1173	324	5	functional	functional	ADJ
ecletica-1173	324	6	activity	activity	NOUN
ecletica-1173	324	7	are	be	AUX
ecletica-1173	324	8	required	require	VERB
ecletica-1173	324	9	;	;	PUNCT
ecletica-1173	324	10	specifically	specifically	ADV
ecletica-1173	324	11	,	,	PUNCT
ecletica-1173	324	12	the	the	DET
ecletica-1173	324	13	capacity	capacity	NOUN
ecletica-1173	324	14	to	to	PART
ecletica-1173	324	15	neutralize	neutralize	VERB
ecletica-1173	324	16	the	the	DET
ecletica-1173	324	17	infectious	infectious	ADJ
ecletica-1173	324	18	agents	agent	NOUN
ecletica-1173	324	19	in	in	ADP
ecletica-1173	324	20	vivo	vivo	NOUN
ecletica-1173	324	21	.	.	PUNCT
ecletica-1173	325	1	human	human	ADJ
ecletica-1173	325	2	capacity	capacity	NOUN
ecletica-1173	325	3	to	to	PART
ecletica-1173	325	4	anticipate	anticipate	VERB
ecletica-1173	325	5	protein	protein	NOUN
ecletica-1173	325	6	function	function	NOUN
ecletica-1173	325	7	is	be	AUX
ecletica-1173	325	8	constrained	constrain	VERB
ecletica-1173	325	9	.	.	PUNCT
ecletica-1173	326	1	the	the	DET
ecletica-1173	326	2	ability	ability	NOUN
ecletica-1173	326	3	to	to	PART
ecletica-1173	326	4	predict	predict	VERB
ecletica-1173	326	5	neutralizing	neutralizing	ADJ
ecletica-1173	326	6	action	action	NOUN
ecletica-1173	326	7	of	of	ADP
ecletica-1173	326	8	an	an	DET
ecletica-1173	326	9	antibody	antibody	NOUN
ecletica-1173	326	10	by	by	ADP
ecletica-1173	326	11	chemical	chemical	ADJ
ecletica-1173	326	12	structure	structure	NOUN
ecletica-1173	326	13	is	be	AUX
ecletica-1173	326	14	for	for	ADP
ecletica-1173	326	15	all	all	DET
ecletica-1173	326	16	intents	intent	NOUN
ecletica-1173	326	17	and	and	CCONJ
ecletica-1173	326	18	purposes	purpose	NOUN
ecletica-1173	326	19	inexistent	inexistent	ADJ
ecletica-1173	326	20	(	(	PUNCT
ecletica-1173	326	21	van	van	PROPN
ecletica-1173	326	22	regenmortel	regenmortel	NOUN
ecletica-1173	326	23	,	,	PUNCT
ecletica-1173	326	24	2000	2000	NUM
ecletica-1173	326	25	;	;	PUNCT
ecletica-1173	326	26	2002	2002	NUM
ecletica-1173	326	27	)	)	PUNCT
ecletica-1173	326	28	.	.	PUNCT
ecletica-1173	327	1	immunization	immunization	NOUN
ecletica-1173	327	2	and	and	CCONJ
ecletica-1173	327	3	protective	protective	ADJ
ecletica-1173	327	4	resistance	resistance	NOUN
ecletica-1173	327	5	have	have	VERB
ecletica-1173	327	6	meaning	meaning	NOUN
ecletica-1173	327	7	at	at	ADP
ecletica-1173	327	8	the	the	DET
ecletica-1173	327	9	level	level	NOUN
ecletica-1173	327	10	of	of	ADP
ecletica-1173	327	11	the	the	DET
ecletica-1173	327	12	entire	entire	ADJ
ecletica-1173	327	13	living	live	VERB
ecletica-1173	327	14	being	being	NOUN
ecletica-1173	327	15	:	:	PUNCT
ecletica-1173	327	16	particles	particle	NOUN
ecletica-1173	327	17	,	,	PUNCT
ecletica-1173	327	18	tissues	tissue	NOUN
ecletica-1173	327	19	and	and	CCONJ
ecletica-1173	327	20	organs	organ	NOUN
ecletica-1173	327	21	can	can	AUX
ecletica-1173	327	22	not	not	PART
ecletica-1173	327	23	be	be	AUX
ecletica-1173	327	24	vaccinated	vaccinate	VERB
ecletica-1173	327	25	.	.	PUNCT
ecletica-1173	328	1	immunization	immunization	NOUN
ecletica-1173	328	2	takes	take	VERB
ecletica-1173	328	3	place	place	NOUN
ecletica-1173	328	4	in	in	ADP
ecletica-1173	328	5	the	the	DET
ecletica-1173	328	6	organic	organic	ADJ
ecletica-1173	328	7	domain	domain	NOUN
ecletica-1173	328	8	and	and	CCONJ
ecletica-1173	328	9	can	can	AUX
ecletica-1173	328	10	not	not	PART
ecletica-1173	328	11	be	be	AUX
ecletica-1173	328	12	decreased	decrease	VERB
ecletica-1173	328	13	to	to	ADP
ecletica-1173	328	14	the	the	DET
ecletica-1173	328	15	level	level	NOUN
ecletica-1173	328	16	of	of	ADP
ecletica-1173	328	17	chemistry	chemistry	NOUN
ecletica-1173	328	18	.	.	PUNCT
ecletica-1173	329	1	third	third	ADJ
ecletica-1173	329	2	,	,	PUNCT
ecletica-1173	329	3	in	in	ADP
ecletica-1173	329	4	spite	spite	NOUN
ecletica-1173	329	5	of	of	ADP
ecletica-1173	329	6	an	an	DET
ecletica-1173	329	7	exceptional	exceptional	ADJ
ecletica-1173	329	8	worldwide	worldwide	ADJ
ecletica-1173	329	9	request	request	NOUN
ecletica-1173	329	10	for	for	ADP
ecletica-1173	329	11	investigation	investigation	NOUN
ecletica-1173	329	12	efforts	effort	NOUN
ecletica-1173	329	13	using	use	VERB
ecletica-1173	329	14	reductionist	reductionist	ADJ
ecletica-1173	329	15	approaches	approach	NOUN
ecletica-1173	329	16	,	,	PUNCT
ecletica-1173	329	17	no	no	DET
ecletica-1173	329	18	immunodeficiency	immunodeficiency	NOUN
ecletica-1173	329	19	infection	infection	NOUN
ecletica-1173	329	20	antibody	antibody	NOUN
ecletica-1173	329	21	is	be	AUX
ecletica-1173	329	22	in	in	ADP
ecletica-1173	329	23	sight	sight	NOUN
ecletica-1173	329	24	(	(	PUNCT
ecletica-1173	329	25	burton	burton	PROPN
ecletica-1173	329	26	and	and	CCONJ
ecletica-1173	329	27	moore	moore	PROPN
ecletica-1173	329	28	,	,	PUNCT
ecletica-1173	329	29	1998	1998	NUM
ecletica-1173	329	30	)	)	PUNCT
ecletica-1173	329	31	.	.	PUNCT
ecletica-1173	330	1	reductionist	reductionist	ADJ
ecletica-1173	330	2	approach	approach	NOUN
ecletica-1173	330	3	on	on	ADP
ecletica-1173	330	4	hiv	hiv	PROPN
ecletica-1173	330	5	immunization	immunization	NOUN
ecletica-1173	330	6	advancement	advancement	NOUN
ecletica-1173	330	7	continues	continue	VERB
ecletica-1173	330	8	to	to	PART
ecletica-1173	330	9	be	be	AUX
ecletica-1173	330	10	advocated	advocate	VERB
ecletica-1173	330	11	(	(	PUNCT
ecletica-1173	330	12	burton	burton	PROPN
ecletica-1173	330	13	et	et	PROPN
ecletica-1173	330	14	al	al	PROPN
ecletica-1173	330	15	.	.	PROPN
ecletica-1173	330	16	,	,	PUNCT
ecletica-1173	330	17	2004	2004	NUM
ecletica-1173	330	18	)	)	PUNCT
ecletica-1173	330	19	,	,	PUNCT
ecletica-1173	330	20	although	although	SCONJ
ecletica-1173	330	21	there	there	PRON
ecletica-1173	330	22	is	be	VERB
ecletica-1173	330	23	no	no	DET
ecletica-1173	330	24	evidence	evidence	NOUN
ecletica-1173	330	25	that	that	SCONJ
ecletica-1173	330	26	it	it	PRON
ecletica-1173	330	27	will	will	AUX
ecletica-1173	330	28	be	be	AUX
ecletica-1173	330	29	efficient	efficient	ADJ
ecletica-1173	330	30	.	.	PUNCT
ecletica-1173	331	1	this	this	DET
ecletica-1173	331	2	approach	approach	NOUN
ecletica-1173	331	3	includes	include	VERB
ecletica-1173	331	4	deciding	decide	VERB
ecletica-1173	331	5	the	the	DET
ecletica-1173	331	6	atomic	atomic	ADJ
ecletica-1173	331	7	structure	structure	NOUN
ecletica-1173	331	8	of	of	ADP
ecletica-1173	331	9	monoclonal	monoclonal	NOUN
ecletica-1173	331	10	antibodies	antibody	NOUN
ecletica-1173	331	11	to	to	ADP
ecletica-1173	331	12	hiv	hiv	PROPN
ecletica-1173	331	13	antigens	antigen	NOUN
ecletica-1173	331	14	using	use	VERB
ecletica-1173	331	15	x	x	NOUN
ecletica-1173	331	16	-	-	NOUN
ecletica-1173	331	17	ray	ray	NOUN
ecletica-1173	331	18	crystallography	crystallography	NOUN
ecletica-1173	331	19	to	to	PART
ecletica-1173	331	20	illustrate	illustrate	VERB
ecletica-1173	331	21	the	the	DET
ecletica-1173	331	22	structure	structure	NOUN
ecletica-1173	331	23	of	of	ADP
ecletica-1173	331	24	hiv	hiv	PROPN
ecletica-1173	331	25	epitopes	epitope	NOUN
ecletica-1173	331	26	.	.	PUNCT
ecletica-1173	332	1	the	the	DET
ecletica-1173	332	2	basis	basis	NOUN
ecletica-1173	332	3	for	for	ADP
ecletica-1173	332	4	these	these	DET
ecletica-1173	332	5	studies	study	NOUN
ecletica-1173	332	6	is	be	AUX
ecletica-1173	332	7	the	the	DET
ecletica-1173	332	8	suspicion	suspicion	NOUN
ecletica-1173	332	9	that	that	SCONJ
ecletica-1173	332	10	information	information	NOUN
ecletica-1173	332	11	of	of	ADP
ecletica-1173	332	12	the	the	DET
ecletica-1173	332	13	structure	structure	NOUN
ecletica-1173	332	14	of	of	ADP
ecletica-1173	332	15	epitopes	epitope	NOUN
ecletica-1173	332	16	that	that	PRON
ecletica-1173	332	17	are	be	AUX
ecletica-1173	332	18	recognized	recognize	VERB
ecletica-1173	332	19	by	by	ADP
ecletica-1173	332	20	neutralizing	neutralize	VERB
ecletica-1173	332	21	antibodies	antibody	NOUN
ecletica-1173	332	22	will	will	AUX
ecletica-1173	332	23	offer	offer	VERB
ecletica-1173	332	24	assistance	assistance	NOUN
ecletica-1173	332	25	to	to	PART
ecletica-1173	332	26	plan	plan	VERB
ecletica-1173	332	27	a	a	DET
ecletica-1173	332	28	viable	viable	ADJ
ecletica-1173	332	29	antibody	antibody	NOUN
ecletica-1173	332	30	against	against	ADP
ecletica-1173	332	31	hiv	hiv	PROPN
ecletica-1173	332	32	.	.	PUNCT
ecletica-1173	333	1	crystallographic	crystallographic	ADJ
ecletica-1173	333	2	x	x	ADJ
ecletica-1173	333	3	-	-	NOUN
ecletica-1173	333	4	ray	ray	NOUN
ecletica-1173	333	5	investigation	investigation	NOUN
ecletica-1173	333	6	of	of	ADP
ecletica-1173	333	7	hivhttp://revista.iq.unesp.br/ojs/index.php/ecletica/index	hivhttp://revista.iq.unesp.br/ojs/index.php/ecletica/index	PROPN
ecletica-1173	333	8	https://doi.org/10.26850/1678-4618eqj.v46.3.2021.p17-32	https://doi.org/10.26850/1678-4618eqj.v46.3.2021.p17-32	PROPN
ecletica-1173	333	9	review	review	NOUN
ecletica-1173	333	10	article	article	NOUN
ecletica-1173	333	11	iq.unesp.br/ecletica	iq.unesp.br/ecletica	PROPN
ecletica-1173	333	12	26	26	NUM
ecletica-1173	333	13	eclética	eclética	PROPN
ecletica-1173	333	14	química	química	PROPN
ecletica-1173	333	15	journal	journal	PROPN
ecletica-1173	333	16	,	,	PUNCT
ecletica-1173	333	17	vol	vol	NOUN
ecletica-1173	333	18	.	.	PROPN
ecletica-1173	333	19	46	46	NUM
ecletica-1173	333	20	,	,	PUNCT
ecletica-1173	333	21	n.	n.	NOUN
ecletica-1173	333	22	3	3	NUM
ecletica-1173	333	23	,	,	PUNCT
ecletica-1173	333	24	2021	2021	NUM
ecletica-1173	333	25	,	,	PUNCT
ecletica-1173	333	26	17	17	NUM
ecletica-1173	333	27	-	-	SYM
ecletica-1173	333	28	32	32	NUM
ecletica-1173	333	29	issn	issn	NOUN
ecletica-1173	333	30	:	:	PUNCT
ecletica-1173	333	31	1678	1678	NUM
ecletica-1173	333	32	-	-	SYM
ecletica-1173	333	33	4618	4618	NUM
ecletica-1173	333	34	doi	doi	NOUN
ecletica-1173	333	35	:	:	PUNCT
ecletica-1173	333	36	10.26850/1678	10.26850/1678	NUM
ecletica-1173	333	37	-	-	SYM
ecletica-1173	333	38	4618eqj.v46.3.2021.p17	4618eqj.v46.3.2021.p17	NOUN
ecletica-1173	333	39	-	-	PUNCT
ecletica-1173	333	40	32	32	NUM
ecletica-1173	333	41	neutralizing	neutralizing	ADJ
ecletica-1173	333	42	antibodies	antibody	NOUN
ecletica-1173	333	43	may	may	AUX
ecletica-1173	333	44	describe	describe	VERB
ecletica-1173	333	45	the	the	DET
ecletica-1173	333	46	structure	structure	NOUN
ecletica-1173	333	47	of	of	ADP
ecletica-1173	333	48	epitopes	epitope	NOUN
ecletica-1173	333	49	inside	inside	ADP
ecletica-1173	333	50	the	the	DET
ecletica-1173	333	51	molecular	molecular	ADJ
ecletica-1173	333	52	pockets	pocket	NOUN
ecletica-1173	333	53	,	,	PUNCT
ecletica-1173	333	54	but	but	CCONJ
ecletica-1173	333	55	it	it	PRON
ecletica-1173	333	56	does	do	AUX
ecletica-1173	333	57	not	not	PART
ecletica-1173	333	58	tell	tell	VERB
ecletica-1173	333	59	how	how	SCONJ
ecletica-1173	333	60	to	to	PART
ecletica-1173	333	61	utilize	utilize	VERB
ecletica-1173	333	62	immunization	immunization	NOUN
ecletica-1173	333	63	and	and	CCONJ
ecletica-1173	333	64	initiate	initiate	VERB
ecletica-1173	333	65	antibodies	antibody	NOUN
ecletica-1173	333	66	with	with	ADP
ecletica-1173	333	67	the	the	DET
ecletica-1173	333	68	same	same	ADJ
ecletica-1173	333	69	specificity	specificity	NOUN
ecletica-1173	333	70	(	(	PUNCT
ecletica-1173	333	71	van	van	NOUN
ecletica-1173	333	72	regenmortel	regenmortel	NOUN
ecletica-1173	333	73	,	,	PUNCT
ecletica-1173	333	74	2002	2002	NUM
ecletica-1173	333	75	;	;	PUNCT
ecletica-1173	333	76	burton	burton	PROPN
ecletica-1173	333	77	and	and	CCONJ
ecletica-1173	333	78	moore	moore	PROPN
ecletica-1173	333	79	,	,	PUNCT
ecletica-1173	333	80	1998	1998	NUM
ecletica-1173	333	81	)	)	PUNCT
ecletica-1173	333	82	.	.	PUNCT
ecletica-1173	334	1	the	the	DET
ecletica-1173	334	2	structures	structure	NOUN
ecletica-1173	334	3	of	of	ADP
ecletica-1173	334	4	epitopes	epitope	NOUN
ecletica-1173	334	5	and	and	CCONJ
ecletica-1173	334	6	paratopes	paratope	NOUN
ecletica-1173	334	7	that	that	PRON
ecletica-1173	334	8	are	be	AUX
ecletica-1173	334	9	displayed	display	VERB
ecletica-1173	334	10	in	in	ADP
ecletica-1173	334	11	a	a	DET
ecletica-1173	334	12	complex	complex	ADJ
ecletica-1173	334	13	describe	describe	VERB
ecletica-1173	334	14	the	the	DET
ecletica-1173	334	15	last	last	ADJ
ecletica-1173	334	16	conformation	conformation	NOUN
ecletica-1173	334	17	of	of	ADP
ecletica-1173	334	18	an	an	DET
ecletica-1173	334	19	energetic	energetic	ADJ
ecletica-1173	334	20	handle	handle	NOUN
ecletica-1173	334	21	by	by	ADP
ecletica-1173	334	22	the	the	DET
ecletica-1173	334	23	alteration	alteration	NOUN
ecletica-1173	334	24	in	in	ADP
ecletica-1173	334	25	the	the	DET
ecletica-1173	334	26	somatic	somatic	ADJ
ecletica-1173	334	27	change	change	NOUN
ecletica-1173	334	28	.	.	PUNCT
ecletica-1173	335	1	it	it	PRON
ecletica-1173	335	2	is	be	AUX
ecletica-1173	335	3	not	not	PART
ecletica-1173	335	4	conceivable	conceivable	ADJ
ecletica-1173	335	5	that	that	SCONJ
ecletica-1173	335	6	the	the	DET
ecletica-1173	335	7	conformation	conformation	NOUN
ecletica-1173	335	8	of	of	ADP
ecletica-1173	335	9	the	the	DET
ecletica-1173	335	10	epitope	epitope	NOUN
ecletica-1173	335	11	on	on	ADP
ecletica-1173	335	12	the	the	DET
ecletica-1173	335	13	immunogen	immunogen	NOUN
ecletica-1173	335	14	is	be	AUX
ecletica-1173	335	15	eventually	eventually	ADV
ecletica-1173	335	16	responsible	responsible	ADJ
ecletica-1173	335	17	for	for	ADP
ecletica-1173	335	18	the	the	DET
ecletica-1173	335	19	appearance	appearance	NOUN
ecletica-1173	335	20	of	of	ADP
ecletica-1173	335	21	neutralizing	neutralize	VERB
ecletica-1173	335	22	antibodies	antibody	NOUN
ecletica-1173	335	23	.	.	PUNCT
ecletica-1173	336	1	8	8	X
ecletica-1173	336	2	.	.	X
ecletica-1173	336	3	organicism	organicism	NOUN
ecletica-1173	336	4	as	as	ADP
ecletica-1173	336	5	a	a	DET
ecletica-1173	336	6	counterproposal	counterproposal	NOUN
ecletica-1173	336	7	in	in	ADP
ecletica-1173	336	8	cancer	cancer	NOUN
ecletica-1173	336	9	treatment	treatment	NOUN
ecletica-1173	336	10	the	the	DET
ecletica-1173	336	11	progress	progress	NOUN
ecletica-1173	336	12	in	in	ADP
ecletica-1173	336	13	molecular	molecular	ADJ
ecletica-1173	336	14	science	science	NOUN
ecletica-1173	336	15	over	over	ADP
ecletica-1173	336	16	the	the	DET
ecletica-1173	336	17	past	past	ADJ
ecletica-1173	336	18	three	three	NUM
ecletica-1173	336	19	decades	decade	NOUN
ecletica-1173	336	20	has	have	AUX
ecletica-1173	336	21	cleared	clear	VERB
ecletica-1173	336	22	the	the	DET
ecletica-1173	336	23	way	way	NOUN
ecletica-1173	336	24	for	for	ADP
ecletica-1173	336	25	a	a	DET
ecletica-1173	336	26	hereditary	hereditary	ADJ
ecletica-1173	336	27	cancer	cancer	NOUN
ecletica-1173	336	28	hypothesis	hypothesis	NOUN
ecletica-1173	336	29	,	,	PUNCT
ecletica-1173	336	30	the	the	DET
ecletica-1173	336	31	somatic	somatic	ADJ
ecletica-1173	336	32	mutation	mutation	NOUN
ecletica-1173	336	33	theory	theory	NOUN
ecletica-1173	336	34	(	(	PUNCT
ecletica-1173	336	35	smt	smt	PROPN
ecletica-1173	336	36	)	)	PUNCT
ecletica-1173	336	37	(	(	PUNCT
ecletica-1173	336	38	boveri	boveri	PROPN
ecletica-1173	336	39	,	,	PUNCT
ecletica-1173	336	40	1929	1929	NUM
ecletica-1173	336	41	;	;	PUNCT
ecletica-1173	336	42	weinberg	weinberg	PROPN
ecletica-1173	336	43	,	,	PUNCT
ecletica-1173	336	44	1998	1998	NUM
ecletica-1173	336	45	)	)	PUNCT
ecletica-1173	336	46	.	.	PUNCT
ecletica-1173	337	1	this	this	DET
ecletica-1173	337	2	hypothesis	hypothesis	NOUN
ecletica-1173	337	3	qualifies	qualify	VERB
ecletica-1173	337	4	as	as	ADP
ecletica-1173	337	5	a	a	DET
ecletica-1173	337	6	“	"	PUNCT
ecletica-1173	337	7	standard	standard	ADJ
ecletica-1173	337	8	hypothesis	hypothesis	NOUN
ecletica-1173	337	9	”	"	PUNCT
ecletica-1173	337	10	because	because	SCONJ
ecletica-1173	337	11	it	it	PRON
ecletica-1173	337	12	has	have	AUX
ecletica-1173	337	13	collected	collect	VERB
ecletica-1173	337	14	most	most	ADJ
ecletica-1173	337	15	of	of	ADP
ecletica-1173	337	16	the	the	DET
ecletica-1173	337	17	financing	financing	NOUN
ecletica-1173	337	18	for	for	ADP
ecletica-1173	337	19	cancer	cancer	NOUN
ecletica-1173	337	20	investigation	investigation	NOUN
ecletica-1173	337	21	.	.	PUNCT
ecletica-1173	338	1	this	this	DET
ecletica-1173	338	2	hypothesis	hypothesis	NOUN
ecletica-1173	338	3	assumes	assume	VERB
ecletica-1173	338	4	that	that	SCONJ
ecletica-1173	338	5	cancer	cancer	NOUN
ecletica-1173	338	6	was	be	AUX
ecletica-1173	338	7	generated	generate	VERB
ecletica-1173	338	8	from	from	ADP
ecletica-1173	338	9	genetic	genetic	ADJ
ecletica-1173	338	10	breakdown	breakdown	NOUN
ecletica-1173	338	11	at	at	ADP
ecletica-1173	338	12	the	the	DET
ecletica-1173	338	13	cellular	cellular	ADJ
ecletica-1173	338	14	level	level	NOUN
ecletica-1173	338	15	.	.	PUNCT
ecletica-1173	339	1	this	this	DET
ecletica-1173	339	2	model	model	NOUN
ecletica-1173	339	3	of	of	ADP
ecletica-1173	339	4	cancer	cancer	NOUN
ecletica-1173	339	5	can	can	AUX
ecletica-1173	339	6	be	be	AUX
ecletica-1173	339	7	followed	follow	VERB
ecletica-1173	339	8	back	back	ADV
ecletica-1173	339	9	to	to	ADP
ecletica-1173	339	10	the	the	DET
ecletica-1173	339	11	work	work	NOUN
ecletica-1173	339	12	of	of	ADP
ecletica-1173	339	13	boveri	boveri	PROPN
ecletica-1173	339	14	(	(	PUNCT
ecletica-1173	339	15	1929	1929	NUM
ecletica-1173	339	16	)	)	PUNCT
ecletica-1173	339	17	.	.	PUNCT
ecletica-1173	340	1	nowadays	nowadays	ADV
ecletica-1173	340	2	,	,	PUNCT
ecletica-1173	340	3	it	it	PRON
ecletica-1173	340	4	is	be	AUX
ecletica-1173	340	5	ordinarily	ordinarily	ADV
ecletica-1173	340	6	defended	defend	VERB
ecletica-1173	340	7	by	by	ADP
ecletica-1173	340	8	weinberg	weinberg	PROPN
ecletica-1173	340	9	(	(	PUNCT
ecletica-1173	340	10	1998	1998	NUM
ecletica-1173	340	11	)	)	PUNCT
ecletica-1173	340	12	.	.	PUNCT
ecletica-1173	341	1	this	this	DET
ecletica-1173	341	2	reductionist	reductionist	ADJ
ecletica-1173	341	3	approach	approach	NOUN
ecletica-1173	341	4	was	be	AUX
ecletica-1173	341	5	explicitly	explicitly	ADV
ecletica-1173	341	6	exposed	expose	VERB
ecletica-1173	341	7	in	in	ADP
ecletica-1173	341	8	weinberg	weinberg	PROPN
ecletica-1173	341	9	’s	’s	PART
ecletica-1173	341	10	book	book	NOUN
ecletica-1173	341	11	one	one	NUM
ecletica-1173	341	12	renegade	renegade	NOUN
ecletica-1173	341	13	cell	cell	NOUN
ecletica-1173	341	14	,	,	PUNCT
ecletica-1173	341	15	that	that	PRON
ecletica-1173	341	16	emphasizes	emphasize	VERB
ecletica-1173	341	17	that	that	SCONJ
ecletica-1173	341	18	the	the	DET
ecletica-1173	341	19	basic	basic	ADJ
ecletica-1173	341	20	part	part	NOUN
ecletica-1173	341	21	of	of	ADP
ecletica-1173	341	22	a	a	DET
ecletica-1173	341	23	single	single	ADJ
ecletica-1173	341	24	mutated	mutate	VERB
ecletica-1173	341	25	cell	cell	NOUN
ecletica-1173	341	26	will	will	AUX
ecletica-1173	341	27	originate	originate	VERB
ecletica-1173	341	28	from	from	ADP
ecletica-1173	341	29	cancer	cancer	NOUN
ecletica-1173	341	30	(	(	PUNCT
ecletica-1173	341	31	weinberg	weinberg	PROPN
ecletica-1173	341	32	,	,	PUNCT
ecletica-1173	341	33	1998	1998	NUM
ecletica-1173	341	34	)	)	PUNCT
ecletica-1173	341	35	.	.	PUNCT
ecletica-1173	342	1	one	one	NUM
ecletica-1173	342	2	alternative	alternative	NOUN
ecletica-1173	342	3	comes	come	VERB
ecletica-1173	342	4	from	from	ADP
ecletica-1173	342	5	traditional	traditional	ADJ
ecletica-1173	342	6	biology	biology	NOUN
ecletica-1173	342	7	and	and	CCONJ
ecletica-1173	342	8	emphasizes	emphasize	VERB
ecletica-1173	342	9	that	that	SCONJ
ecletica-1173	342	10	the	the	DET
ecletica-1173	342	11	living	live	VERB
ecletica-1173	342	12	being	being	NOUN
ecletica-1173	342	13	must	must	AUX
ecletica-1173	342	14	be	be	AUX
ecletica-1173	342	15	studied	study	VERB
ecletica-1173	342	16	as	as	ADP
ecletica-1173	342	17	a	a	DET
ecletica-1173	342	18	whole	whole	NOUN
ecletica-1173	342	19	.	.	PUNCT
ecletica-1173	343	1	the	the	DET
ecletica-1173	343	2	central	central	ADJ
ecletica-1173	343	3	point	point	NOUN
ecletica-1173	343	4	of	of	ADP
ecletica-1173	343	5	this	this	DET
ecletica-1173	343	6	research	research	NOUN
ecletica-1173	343	7	is	be	AUX
ecletica-1173	343	8	the	the	DET
ecletica-1173	343	9	work	work	NOUN
ecletica-1173	343	10	of	of	ADP
ecletica-1173	343	11	waddington	waddington	PROPN
ecletica-1173	343	12	(	(	PUNCT
ecletica-1173	343	13	1935	1935	NUM
ecletica-1173	343	14	)	)	PUNCT
ecletica-1173	343	15	.	.	PUNCT
ecletica-1173	344	1	according	accord	VERB
ecletica-1173	344	2	to	to	ADP
ecletica-1173	344	3	the	the	DET
ecletica-1173	344	4	tissue	tissue	NOUN
ecletica-1173	344	5	organizational	organizational	ADJ
ecletica-1173	344	6	field	field	NOUN
ecletica-1173	344	7	theory	theory	NOUN
ecletica-1173	344	8	(	(	PUNCT
ecletica-1173	344	9	toft	toft	NOUN
ecletica-1173	344	10	)	)	PUNCT
ecletica-1173	344	11	,	,	PUNCT
ecletica-1173	344	12	the	the	DET
ecletica-1173	344	13	causes	cause	NOUN
ecletica-1173	344	14	of	of	ADP
ecletica-1173	344	15	cancer	cancer	NOUN
ecletica-1173	344	16	should	should	AUX
ecletica-1173	344	17	be	be	AUX
ecletica-1173	344	18	investigated	investigate	VERB
ecletica-1173	344	19	not	not	PART
ecletica-1173	344	20	at	at	ADP
ecletica-1173	344	21	the	the	DET
ecletica-1173	344	22	hereditary	hereditary	ADJ
ecletica-1173	344	23	level	level	NOUN
ecletica-1173	344	24	,	,	PUNCT
ecletica-1173	344	25	but	but	CCONJ
ecletica-1173	344	26	at	at	ADP
ecletica-1173	344	27	the	the	DET
ecletica-1173	344	28	tissue	tissue	NOUN
ecletica-1173	344	29	level	level	NOUN
ecletica-1173	344	30	.	.	PUNCT
ecletica-1173	345	1	the	the	DET
ecletica-1173	345	2	toft	toft	NOUN
ecletica-1173	345	3	claims	claim	VERB
ecletica-1173	345	4	that	that	SCONJ
ecletica-1173	345	5	cancer	cancer	NOUN
ecletica-1173	345	6	starts	start	VERB
ecletica-1173	345	7	from	from	ADP
ecletica-1173	345	8	a	a	DET
ecletica-1173	345	9	disturbance	disturbance	NOUN
ecletica-1173	345	10	of	of	ADP
ecletica-1173	345	11	tissue	tissue	NOUN
ecletica-1173	345	12	organization	organization	NOUN
ecletica-1173	345	13	.	.	PUNCT
ecletica-1173	346	1	this	this	DET
ecletica-1173	346	2	theory	theory	NOUN
ecletica-1173	346	3	has	have	AUX
ecletica-1173	346	4	been	be	AUX
ecletica-1173	346	5	examined	examine	VERB
ecletica-1173	346	6	by	by	ADP
ecletica-1173	346	7	dolberg	dolberg	NOUN
ecletica-1173	346	8	and	and	CCONJ
ecletica-1173	346	9	bissell	bissell	PROPN
ecletica-1173	346	10	(	(	PUNCT
ecletica-1173	346	11	1984	1984	NUM
ecletica-1173	346	12	)	)	PUNCT
ecletica-1173	346	13	and	and	CCONJ
ecletica-1173	346	14	characterizes	characterize	VERB
ecletica-1173	346	15	the	the	DET
ecletica-1173	346	16	conceptual	conceptual	ADJ
ecletica-1173	346	17	system	system	NOUN
ecletica-1173	346	18	with	with	ADP
ecletica-1173	346	19	an	an	DET
ecletica-1173	346	20	organicist	organicist	ADJ
ecletica-1173	346	21	point	point	NOUN
ecletica-1173	346	22	of	of	ADP
ecletica-1173	346	23	view	view	NOUN
ecletica-1173	346	24	.	.	PUNCT
ecletica-1173	347	1	the	the	DET
ecletica-1173	347	2	smt	smt	PROPN
ecletica-1173	347	3	approach	approach	NOUN
ecletica-1173	347	4	,	,	PUNCT
ecletica-1173	347	5	whereby	whereby	SCONJ
ecletica-1173	347	6	the	the	DET
ecletica-1173	347	7	cause	cause	NOUN
ecletica-1173	347	8	of	of	ADP
ecletica-1173	347	9	cancer	cancer	NOUN
ecletica-1173	347	10	must	must	AUX
ecletica-1173	347	11	be	be	AUX
ecletica-1173	347	12	inquired	inquire	VERB
ecletica-1173	347	13	about	about	ADP
ecletica-1173	347	14	at	at	ADP
ecletica-1173	347	15	the	the	DET
ecletica-1173	347	16	hereditary	hereditary	ADJ
ecletica-1173	347	17	level	level	NOUN
ecletica-1173	347	18	,	,	PUNCT
ecletica-1173	347	19	has	have	AUX
ecletica-1173	347	20	regularly	regularly	ADV
ecletica-1173	347	21	been	be	AUX
ecletica-1173	347	22	qualified	qualified	ADJ
ecletica-1173	347	23	as	as	ADP
ecletica-1173	347	24	an	an	DET
ecletica-1173	347	25	illustration	illustration	NOUN
ecletica-1173	347	26	of	of	ADP
ecletica-1173	347	27	reductionism	reductionism	NOUN
ecletica-1173	347	28	,	,	PUNCT
ecletica-1173	347	29	and	and	CCONJ
ecletica-1173	347	30	more	more	ADV
ecletica-1173	347	31	accurately	accurately	ADV
ecletica-1173	347	32	as	as	ADP
ecletica-1173	347	33	hereditary	hereditary	ADJ
ecletica-1173	347	34	reductionism	reductionism	NOUN
ecletica-1173	347	35	.	.	PUNCT
ecletica-1173	348	1	the	the	DET
ecletica-1173	348	2	ideas	idea	NOUN
ecletica-1173	348	3	behind	behind	ADP
ecletica-1173	348	4	smt	smt	PROPN
ecletica-1173	348	5	inside	inside	ADP
ecletica-1173	348	6	hereditary	hereditary	ADJ
ecletica-1173	348	7	qualities	quality	NOUN
ecletica-1173	348	8	based	base	VERB
ecletica-1173	348	9	on	on	ADP
ecletica-1173	348	10	reductionist	reductionist	ADJ
ecletica-1173	348	11	paradigm	paradigm	NOUN
ecletica-1173	348	12	really	really	ADV
ecletica-1173	348	13	rose	rise	VERB
ecletica-1173	348	14	within	within	ADP
ecletica-1173	348	15	the	the	DET
ecletica-1173	348	16	1970s	1970s	NUM
ecletica-1173	348	17	.	.	PUNCT
ecletica-1173	349	1	at	at	ADP
ecletica-1173	349	2	the	the	DET
ecletica-1173	349	3	time	time	NOUN
ecletica-1173	349	4	,	,	PUNCT
ecletica-1173	349	5	an	an	DET
ecletica-1173	349	6	impressive	impressive	ADJ
ecletica-1173	349	7	number	number	NOUN
ecletica-1173	349	8	of	of	ADP
ecletica-1173	349	9	carcinogenic	carcinogenic	ADJ
ecletica-1173	349	10	chemicals	chemical	NOUN
ecletica-1173	349	11	could	could	AUX
ecletica-1173	349	12	cause	cause	VERB
ecletica-1173	349	13	hereditary	hereditary	ADJ
ecletica-1173	349	14	changes	change	NOUN
ecletica-1173	349	15	.	.	PUNCT
ecletica-1173	350	1	afterward	afterward	ADV
ecletica-1173	350	2	,	,	PUNCT
ecletica-1173	350	3	it	it	PRON
ecletica-1173	350	4	was	be	AUX
ecletica-1173	350	5	found	find	VERB
ecletica-1173	350	6	that	that	SCONJ
ecletica-1173	350	7	a	a	DET
ecletica-1173	350	8	few	few	ADJ
ecletica-1173	350	9	of	of	ADP
ecletica-1173	350	10	the	the	DET
ecletica-1173	350	11	so	so	ADV
ecletica-1173	350	12	-	-	PUNCT
ecletica-1173	350	13	called	call	VERB
ecletica-1173	350	14	tumor	tumor	NOUN
ecletica-1173	350	15	infections	infection	NOUN
ecletica-1173	350	16	(	(	PUNCT
ecletica-1173	350	17	also	also	ADV
ecletica-1173	350	18	called	call	VERB
ecletica-1173	350	19	quality	quality	NOUN
ecletica-1173	350	20	transformers	transformer	NOUN
ecletica-1173	350	21	or	or	CCONJ
ecletica-1173	350	22	oncogenes	oncogene	NOUN
ecletica-1173	350	23	)	)	PUNCT
ecletica-1173	350	24	could	could	AUX
ecletica-1173	350	25	lead	lead	VERB
ecletica-1173	350	26	to	to	ADP
ecletica-1173	350	27	the	the	DET
ecletica-1173	350	28	advancement	advancement	NOUN
ecletica-1173	350	29	of	of	ADP
ecletica-1173	350	30	tumors	tumor	NOUN
ecletica-1173	350	31	that	that	PRON
ecletica-1173	350	32	carry	carry	VERB
ecletica-1173	350	33	hereditary	hereditary	ADJ
ecletica-1173	350	34	transformations	transformation	NOUN
ecletica-1173	350	35	in	in	ADP
ecletica-1173	350	36	tainted	tainted	ADJ
ecletica-1173	350	37	cells	cell	NOUN
ecletica-1173	350	38	.	.	PUNCT
ecletica-1173	351	1	at	at	ADP
ecletica-1173	351	2	this	this	DET
ecletica-1173	351	3	point	point	NOUN
ecletica-1173	351	4	,	,	PUNCT
ecletica-1173	351	5	the	the	DET
ecletica-1173	351	6	hereditary	hereditary	ADJ
ecletica-1173	351	7	cause	cause	NOUN
ecletica-1173	351	8	of	of	ADP
ecletica-1173	351	9	cancer	cancer	NOUN
ecletica-1173	351	10	changed	change	VERB
ecletica-1173	351	11	from	from	ADP
ecletica-1173	351	12	exogenous	exogenous	ADJ
ecletica-1173	351	13	to	to	ADP
ecletica-1173	351	14	endogenous	endogenous	ADJ
ecletica-1173	351	15	and	and	CCONJ
ecletica-1173	351	16	a	a	DET
ecletica-1173	351	17	few	few	ADJ
ecletica-1173	351	18	endogenous	endogenous	ADJ
ecletica-1173	351	19	oncogenes	oncogene	NOUN
ecletica-1173	351	20	were	be	AUX
ecletica-1173	351	21	distinguished	distinguish	VERB
ecletica-1173	351	22	as	as	ADP
ecletica-1173	351	23	transformed	transform	VERB
ecletica-1173	351	24	shapes	shape	NOUN
ecletica-1173	351	25	of	of	ADP
ecletica-1173	351	26	ordinary	ordinary	ADJ
ecletica-1173	351	27	cell	cell	NOUN
ecletica-1173	351	28	qualities	quality	NOUN
ecletica-1173	351	29	.	.	PUNCT
ecletica-1173	352	1	later	later	ADJ
ecletica-1173	352	2	researches	research	NOUN
ecletica-1173	352	3	showed	show	VERB
ecletica-1173	352	4	the	the	DET
ecletica-1173	352	5	true	true	ADJ
ecletica-1173	352	6	complexity	complexity	NOUN
ecletica-1173	352	7	of	of	ADP
ecletica-1173	352	8	cancer	cancer	NOUN
ecletica-1173	352	9	.	.	PUNCT
ecletica-1173	353	1	it	it	PRON
ecletica-1173	353	2	was	be	AUX
ecletica-1173	353	3	found	find	VERB
ecletica-1173	353	4	that	that	SCONJ
ecletica-1173	353	5	a	a	DET
ecletica-1173	353	6	few	few	ADJ
ecletica-1173	353	7	cases	case	NOUN
ecletica-1173	353	8	of	of	ADP
ecletica-1173	353	9	carcinogenesis	carcinogenesis	NOUN
ecletica-1173	353	10	could	could	AUX
ecletica-1173	353	11	be	be	AUX
ecletica-1173	353	12	understood	understand	VERB
ecletica-1173	353	13	as	as	ADP
ecletica-1173	353	14	a	a	DET
ecletica-1173	353	15	multistep	multistep	NOUN
ecletica-1173	353	16	to	to	PART
ecletica-1173	353	17	prepare	prepare	VERB
ecletica-1173	353	18	numerous	numerous	ADJ
ecletica-1173	353	19	oncogenes	oncogene	NOUN
ecletica-1173	353	20	,	,	PUNCT
ecletica-1173	353	21	as	as	ADV
ecletica-1173	353	22	well	well	ADV
ecletica-1173	353	23	as	as	ADP
ecletica-1173	353	24	possibly	possibly	ADV
ecletica-1173	353	25	one	one	NUM
ecletica-1173	353	26	or	or	CCONJ
ecletica-1173	353	27	more	more	ADJ
ecletica-1173	353	28	anti	anti	ADJ
ecletica-1173	353	29	-	-	ADJ
ecletica-1173	353	30	oncogenes	oncogenes	ADJ
ecletica-1173	353	31	or	or	CCONJ
ecletica-1173	353	32	tumor	tumor	NOUN
ecletica-1173	353	33	silencers	silencer	NOUN
ecletica-1173	353	34	.	.	PUNCT
ecletica-1173	354	1	around	around	ADV
ecletica-1173	354	2	100	100	NUM
ecletica-1173	354	3	oncogenes	oncogene	NOUN
ecletica-1173	354	4	and	and	CCONJ
ecletica-1173	354	5	15	15	NUM
ecletica-1173	354	6	anti	anti	ADJ
ecletica-1173	354	7	-	-	ADJ
ecletica-1173	354	8	oncogenes	oncogene	NOUN
ecletica-1173	354	9	have	have	AUX
ecletica-1173	354	10	been	be	AUX
ecletica-1173	354	11	recognized	recognize	VERB
ecletica-1173	354	12	(	(	PUNCT
ecletica-1173	354	13	hanahan	hanahan	PROPN
ecletica-1173	354	14	and	and	CCONJ
ecletica-1173	354	15	weinberg	weinberg	PROPN
ecletica-1173	354	16	,	,	PUNCT
ecletica-1173	354	17	2000	2000	NUM
ecletica-1173	354	18	)	)	PUNCT
ecletica-1173	354	19	.	.	PUNCT
ecletica-1173	355	1	the	the	DET
ecletica-1173	355	2	cell	cell	NOUN
ecletica-1173	355	3	cycle	cycle	NOUN
ecletica-1173	355	4	clock	clock	NOUN
ecletica-1173	355	5	was	be	AUX
ecletica-1173	355	6	considered	consider	VERB
ecletica-1173	355	7	critical	critical	ADJ
ecletica-1173	355	8	,	,	PUNCT
ecletica-1173	355	9	as	as	SCONJ
ecletica-1173	355	10	were	be	AUX
ecletica-1173	355	11	the	the	DET
ecletica-1173	355	12	characteristics	characteristic	NOUN
ecletica-1173	355	13	of	of	ADP
ecletica-1173	355	14	the	the	DET
ecletica-1173	355	15	cell	cell	NOUN
ecletica-1173	355	16	life	life	NOUN
ecletica-1173	355	17	.	.	PUNCT
ecletica-1173	356	1	the	the	DET
ecletica-1173	356	2	explanation	explanation	NOUN
ecletica-1173	356	3	described	describe	VERB
ecletica-1173	356	4	by	by	ADP
ecletica-1173	356	5	weinberg	weinberg	PROPN
ecletica-1173	356	6	has	have	AUX
ecletica-1173	356	7	been	be	AUX
ecletica-1173	356	8	amplified	amplify	VERB
ecletica-1173	356	9	beyond	beyond	ADP
ecletica-1173	356	10	intracellular	intracellular	ADJ
ecletica-1173	356	11	hereditary	hereditary	ADJ
ecletica-1173	356	12	causes	cause	NOUN
ecletica-1173	356	13	.	.	PUNCT
ecletica-1173	357	1	nowadays	nowadays	ADV
ecletica-1173	357	2	,	,	PUNCT
ecletica-1173	357	3	there	there	PRON
ecletica-1173	357	4	are	be	VERB
ecletica-1173	357	5	numerous	numerous	ADJ
ecletica-1173	357	6	biomolecular	biomolecular	ADJ
ecletica-1173	357	7	pathways	pathway	NOUN
ecletica-1173	357	8	,	,	PUNCT
ecletica-1173	357	9	including	include	VERB
ecletica-1173	357	10	signals	signal	NOUN
ecletica-1173	357	11	of	of	ADP
ecletica-1173	357	12	communication	communication	NOUN
ecletica-1173	357	13	between	between	ADP
ecletica-1173	357	14	cells	cell	NOUN
ecletica-1173	357	15	.	.	PUNCT
ecletica-1173	358	1	in	in	ADP
ecletica-1173	358	2	carcinogenesis	carcinogenesis	NOUN
ecletica-1173	358	3	,	,	PUNCT
ecletica-1173	358	4	the	the	DET
ecletica-1173	358	5	cells	cell	NOUN
ecletica-1173	358	6	acquire	acquire	VERB
ecletica-1173	358	7	six	six	NUM
ecletica-1173	358	8	particular	particular	ADJ
ecletica-1173	358	9	capacities	capacity	NOUN
ecletica-1173	358	10	:	:	PUNCT
ecletica-1173	358	11	specification	specification	NOUN
ecletica-1173	358	12	,	,	PUNCT
ecletica-1173	358	13	“	"	PUNCT
ecletica-1173	358	14	self	self	NOUN
ecletica-1173	358	15	-	-	PUNCT
ecletica-1173	358	16	sufficiency	sufficiency	NOUN
ecletica-1173	358	17	”	"	PUNCT
ecletica-1173	358	18	in	in	ADP
ecletica-1173	358	19	development	development	NOUN
ecletica-1173	358	20	signals	signal	NOUN
ecletica-1173	358	21	,	,	PUNCT
ecletica-1173	358	22	coldheartedness	coldheartedness	NOUN
ecletica-1173	358	23	inhibitory	inhibitory	ADJ
ecletica-1173	358	24	development	development	NOUN
ecletica-1173	358	25	signals	signal	NOUN
ecletica-1173	358	26	(	(	PUNCT
ecletica-1173	358	27	antigrowth	antigrowth	PROPN
ecletica-1173	358	28	)	)	PUNCT
ecletica-1173	358	29	,	,	PUNCT
ecletica-1173	358	30	avoidance	avoidance	NOUN
ecletica-1173	358	31	of	of	ADP
ecletica-1173	358	32	modified	modify	VERB
ecletica-1173	358	33	cell	cell	NOUN
ecletica-1173	358	34	passing	passing	NOUN
ecletica-1173	358	35	(	(	PUNCT
ecletica-1173	358	36	apoptosis	apoptosis	NOUN
ecletica-1173	358	37	)	)	PUNCT
ecletica-1173	358	38	,	,	PUNCT
ecletica-1173	358	39	replicative	replicative	ADJ
ecletica-1173	358	40	potential	potential	ADJ
ecletica-1173	358	41	boundless	boundless	NOUN
ecletica-1173	358	42	,	,	PUNCT
ecletica-1173	358	43	maintained	maintain	VERB
ecletica-1173	358	44	angiogenesis	angiogenesis	NOUN
ecletica-1173	358	45	in	in	ADP
ecletica-1173	358	46	tissue	tissue	NOUN
ecletica-1173	358	47	(	(	PUNCT
ecletica-1173	358	48	hanahan	hanahan	PROPN
ecletica-1173	358	49	and	and	CCONJ
ecletica-1173	358	50	weinberg	weinberg	PROPN
ecletica-1173	358	51	,	,	PUNCT
ecletica-1173	358	52	2000	2000	NUM
ecletica-1173	358	53	)	)	PUNCT
ecletica-1173	358	54	.	.	PUNCT
ecletica-1173	359	1	each	each	PRON
ecletica-1173	359	2	of	of	ADP
ecletica-1173	359	3	these	these	DET
ecletica-1173	359	4	capabilities	capability	NOUN
ecletica-1173	359	5	may	may	AUX
ecletica-1173	359	6	be	be	AUX
ecletica-1173	359	7	obtained	obtain	VERB
ecletica-1173	359	8	by	by	ADP
ecletica-1173	359	9	distinctive	distinctive	ADJ
ecletica-1173	359	10	molecular	molecular	ADJ
ecletica-1173	359	11	pathways	pathway	NOUN
ecletica-1173	359	12	:	:	PUNCT
ecletica-1173	359	13	self	self	NOUN
ecletica-1173	359	14	-	-	PUNCT
ecletica-1173	359	15	sufficiency	sufficiency	NOUN
ecletica-1173	359	16	in	in	ADP
ecletica-1173	359	17	development	development	NOUN
ecletica-1173	359	18	signals	signal	NOUN
ecletica-1173	359	19	coming	come	VERB
ecletica-1173	359	20	about	about	ADV
ecletica-1173	359	21	in	in	ADP
ecletica-1173	359	22	independent	independent	ADJ
ecletica-1173	359	23	cell	cell	NOUN
ecletica-1173	359	24	development	development	NOUN
ecletica-1173	359	25	and	and	CCONJ
ecletica-1173	359	26	multiplication	multiplication	NOUN
ecletica-1173	359	27	that	that	PRON
ecletica-1173	359	28	may	may	AUX
ecletica-1173	359	29	be	be	AUX
ecletica-1173	359	30	searched	search	VERB
ecletica-1173	359	31	by	by	ADP
ecletica-1173	359	32	the	the	DET
ecletica-1173	359	33	modification	modification	NOUN
ecletica-1173	359	34	of	of	ADP
ecletica-1173	359	35	extracellular	extracellular	ADJ
ecletica-1173	359	36	development	development	NOUN
ecletica-1173	359	37	signals	signal	NOUN
ecletica-1173	359	38	,	,	PUNCT
ecletica-1173	359	39	transcellular	transcellular	NOUN
ecletica-1173	359	40	transducers	transducer	NOUN
ecletica-1173	359	41	of	of	ADP
ecletica-1173	359	42	such	such	ADJ
ecletica-1173	359	43	signals	signal	NOUN
ecletica-1173	359	44	or	or	CCONJ
ecletica-1173	359	45	circuits	circuit	NOUN
ecletica-1173	359	46	,	,	PUNCT
ecletica-1173	359	47	which	which	PRON
ecletica-1173	359	48	decipher	decipher	ADV
ecletica-1173	359	49	these	these	DET
ecletica-1173	359	50	signals	signal	NOUN
ecletica-1173	359	51	into	into	ADP
ecletica-1173	359	52	activity	activity	NOUN
ecletica-1173	359	53	.	.	PUNCT
ecletica-1173	360	1	these	these	DET
ecletica-1173	360	2	six	six	NUM
ecletica-1173	360	3	capabilities	capability	NOUN
ecletica-1173	360	4	would	would	AUX
ecletica-1173	360	5	indeed	indeed	ADV
ecletica-1173	360	6	be	be	AUX
ecletica-1173	360	7	empowered	empower	VERB
ecletica-1173	360	8	by	by	ADP
ecletica-1173	360	9	a	a	DET
ecletica-1173	360	10	seventh	seventh	ADJ
ecletica-1173	360	11	characteristic	characteristic	NOUN
ecletica-1173	360	12	,	,	PUNCT
ecletica-1173	360	13	the	the	DET
ecletica-1173	360	14	genomic	genomic	NOUN
ecletica-1173	360	15	precariousness	precariousness	NOUN
ecletica-1173	360	16	,	,	PUNCT
ecletica-1173	360	17	in	in	ADP
ecletica-1173	360	18	some	some	DET
ecletica-1173	360	19	cases	case	NOUN
ecletica-1173	360	20	it	it	PRON
ecletica-1173	360	21	is	be	AUX
ecletica-1173	360	22	known	know	VERB
ecletica-1173	360	23	as	as	ADP
ecletica-1173	360	24	“	"	PUNCT
ecletica-1173	360	25	more	more	ADV
ecletica-1173	360	26	prominent	prominent	ADJ
ecletica-1173	360	27	variability	variability	NOUN
ecletica-1173	360	28	”	"	PUNCT
ecletica-1173	360	29	.	.	PUNCT
ecletica-1173	361	1	the	the	DET
ecletica-1173	361	2	definition	definition	NOUN
ecletica-1173	361	3	of	of	ADP
ecletica-1173	361	4	the	the	DET
ecletica-1173	361	5	smt	smt	PROPN
ecletica-1173	361	6	has	have	AUX
ecletica-1173	361	7	been	be	AUX
ecletica-1173	361	8	reformulated	reformulate	VERB
ecletica-1173	361	9	in	in	ADP
ecletica-1173	361	10	terms	term	NOUN
ecletica-1173	361	11	of	of	ADP
ecletica-1173	361	12	“	"	PUNCT
ecletica-1173	361	13	heterotypic	heterotypic	NOUN
ecletica-1173	361	14	intuitive	intuitive	ADJ
ecletica-1173	361	15	”	"	PUNCT
ecletica-1173	361	16	between	between	ADP
ecletica-1173	361	17	early	early	ADJ
ecletica-1173	361	18	tumor	tumor	NOUN
ecletica-1173	361	19	cells	cell	NOUN
ecletica-1173	361	20	and	and	CCONJ
ecletica-1173	361	21	their	their	PRON
ecletica-1173	361	22	ordinary	ordinary	ADJ
ecletica-1173	361	23	neighbors	neighbor	NOUN
ecletica-1173	361	24	.	.	PUNCT
ecletica-1173	362	1	(	(	PUNCT
ecletica-1173	362	2	hanahan	hanahan	PROPN
ecletica-1173	362	3	and	and	CCONJ
ecletica-1173	362	4	weinberg	weinberg	PROPN
ecletica-1173	362	5	,	,	PUNCT
ecletica-1173	362	6	2000	2000	NUM
ecletica-1173	362	7	)	)	PUNCT
ecletica-1173	362	8	.	.	PUNCT
ecletica-1173	363	1	hereditary	hereditary	ADJ
ecletica-1173	363	2	reductionism	reductionism	NOUN
ecletica-1173	363	3	,	,	PUNCT
ecletica-1173	363	4	which	which	PRON
ecletica-1173	363	5	describes	describe	VERB
ecletica-1173	363	6	the	the	DET
ecletica-1173	363	7	origin	origin	NOUN
ecletica-1173	363	8	of	of	ADP
ecletica-1173	363	9	cancer	cancer	NOUN
ecletica-1173	363	10	by	by	ADP
ecletica-1173	363	11	a	a	DET
ecletica-1173	363	12	cell	cell	NOUN
ecletica-1173	363	13	mutation	mutation	NOUN
ecletica-1173	363	14	,	,	PUNCT
ecletica-1173	363	15	has	have	AUX
ecletica-1173	363	16	been	be	AUX
ecletica-1173	363	17	adjusted	adjust	VERB
ecletica-1173	363	18	to	to	PART
ecletica-1173	363	19	cover	cover	VERB
ecletica-1173	363	20	the	the	DET
ecletica-1173	363	21	complexity	complexity	NOUN
ecletica-1173	363	22	of	of	ADP
ecletica-1173	363	23	carcinogenesis	carcinogenesis	NOUN
ecletica-1173	363	24	and	and	CCONJ
ecletica-1173	363	25	the	the	DET
ecletica-1173	363	26	variety	variety	NOUN
ecletica-1173	363	27	of	of	ADP
ecletica-1173	363	28	atomic	atomic	ADJ
ecletica-1173	363	29	pathways	pathway	NOUN
ecletica-1173	363	30	that	that	PRON
ecletica-1173	363	31	lead	lead	VERB
ecletica-1173	363	32	to	to	ADP
ecletica-1173	363	33	tumor	tumor	NOUN
ecletica-1173	363	34	cell	cell	NOUN
ecletica-1173	363	35	multiplication	multiplication	NOUN
ecletica-1173	363	36	.	.	PUNCT
ecletica-1173	364	1	although	although	SCONJ
ecletica-1173	364	2	smt	smt	PROPN
ecletica-1173	364	3	presents	present	VERB
ecletica-1173	364	4	a	a	DET
ecletica-1173	364	5	clear	clear	ADJ
ecletica-1173	364	6	limitation	limitation	NOUN
ecletica-1173	364	7	to	to	PART
ecletica-1173	364	8	explain	explain	VERB
ecletica-1173	364	9	the	the	DET
ecletica-1173	364	10	cancer	cancer	NOUN
ecletica-1173	364	11	origin	origin	NOUN
ecletica-1173	364	12	,	,	PUNCT
ecletica-1173	364	13	the	the	DET
ecletica-1173	364	14	paradigm	paradigm	NOUN
ecletica-1173	364	15	centered	center	VERB
ecletica-1173	364	16	on	on	ADP
ecletica-1173	364	17	molecular	molecular	ADJ
ecletica-1173	364	18	substances	substance	NOUN
ecletica-1173	364	19	remains	remain	VERB
ecletica-1173	364	20	the	the	DET
ecletica-1173	364	21	most	most	ADV
ecletica-1173	364	22	fundamental	fundamental	ADJ
ecletica-1173	364	23	explanation	explanation	NOUN
ecletica-1173	364	24	.	.	PUNCT
ecletica-1173	365	1	cancer	cancer	NOUN
ecletica-1173	365	2	approach	approach	NOUN
ecletica-1173	365	3	proposed	propose	VERB
ecletica-1173	365	4	by	by	ADP
ecletica-1173	365	5	sonnenschein	sonnenschein	NOUN
ecletica-1173	365	6	and	and	CCONJ
ecletica-1173	365	7	soto	soto	PROPN
ecletica-1173	365	8	(	(	PUNCT
ecletica-1173	365	9	2020	2020	NUM
ecletica-1173	365	10	)	)	PUNCT
ecletica-1173	365	11	and	and	CCONJ
ecletica-1173	365	12	their	their	PRON
ecletica-1173	365	13	group	group	NOUN
ecletica-1173	365	14	is	be	AUX
ecletica-1173	365	15	based	base	VERB
ecletica-1173	365	16	on	on	ADP
ecletica-1173	365	17	tissue	tissue	NOUN
ecletica-1173	365	18	investigation	investigation	NOUN
ecletica-1173	365	19	.	.	PUNCT
ecletica-1173	366	1	the	the	DET
ecletica-1173	366	2	toft	toft	NOUN
ecletica-1173	366	3	finds	find	VERB
ecletica-1173	366	4	an	an	DET
ecletica-1173	366	5	explanation	explanation	NOUN
ecletica-1173	366	6	of	of	ADP
ecletica-1173	366	7	cancer	cancer	NOUN
ecletica-1173	366	8	in	in	ADP
ecletica-1173	366	9	terms	term	NOUN
ecletica-1173	366	10	of	of	ADP
ecletica-1173	366	11	disturbance	disturbance	NOUN
ecletica-1173	366	12	of	of	ADP
ecletica-1173	366	13	tissue	tissue	NOUN
ecletica-1173	366	14	organization	organization	NOUN
ecletica-1173	366	15	as	as	ADP
ecletica-1173	366	16	opposition	opposition	NOUN
ecletica-1173	366	17	to	to	ADP
ecletica-1173	366	18	the	the	DET
ecletica-1173	366	19	expression	expression	NOUN
ecletica-1173	366	20	of	of	ADP
ecletica-1173	366	21	a	a	DET
ecletica-1173	366	22	defective	defective	ADJ
ecletica-1173	366	23	gene	gene	NOUN
ecletica-1173	366	24	.	.	PUNCT
ecletica-1173	367	1	the	the	DET
ecletica-1173	367	2	toft	toft	NOUN
ecletica-1173	367	3	is	be	AUX
ecletica-1173	367	4	based	base	VERB
ecletica-1173	367	5	on	on	ADP
ecletica-1173	367	6	two	two	NUM
ecletica-1173	367	7	fundamental	fundamental	ADJ
ecletica-1173	367	8	presumptions	presumption	NOUN
ecletica-1173	367	9	:	:	PUNCT
ecletica-1173	367	10	(	(	PUNCT
ecletica-1173	367	11	i	i	NOUN
ecletica-1173	367	12	)	)	PUNCT
ecletica-1173	367	13	expansion	expansion	NOUN
ecletica-1173	367	14	is	be	AUX
ecletica-1173	367	15	the	the	DET
ecletica-1173	367	16	default	default	NOUN
ecletica-1173	367	17	state	state	NOUN
ecletica-1173	367	18	of	of	ADP
ecletica-1173	367	19	all	all	DET
ecletica-1173	367	20	cells	cell	NOUN
ecletica-1173	367	21	,	,	PUNCT
ecletica-1173	367	22	and	and	CCONJ
ecletica-1173	367	23	(	(	PUNCT
ecletica-1173	367	24	ii	ii	NOUN
ecletica-1173	367	25	)	)	PUNCT
ecletica-1173	367	26	carcinogens	carcinogen	NOUN
ecletica-1173	367	27	act	act	VERB
ecletica-1173	367	28	initially	initially	ADV
ecletica-1173	367	29	due	due	ADP
ecletica-1173	367	30	to	to	ADP
ecletica-1173	367	31	distribution	distribution	NOUN
ecletica-1173	367	32	of	of	ADP
ecletica-1173	367	33	the	the	DET
ecletica-1173	367	34	http://revista.iq.unesp.br/ojs/index.php/ecletica/index	http://revista.iq.unesp.br/ojs/index.php/ecletica/index	NOUN
ecletica-1173	367	35	https://doi.org/10.26850/1678-4618eqj.v46.3.2021.p17-32	https://doi.org/10.26850/1678-4618eqj.v46.3.2021.p17-32	PROPN
ecletica-1173	367	36	review	review	NOUN
ecletica-1173	367	37	article	article	NOUN
ecletica-1173	367	38	iq.unesp.br/ecletica	iq.unesp.br/ecletica	PROPN
ecletica-1173	367	39	27	27	NUM
ecletica-1173	367	40	eclética	eclética	PROPN
ecletica-1173	367	41	química	química	PROPN
ecletica-1173	367	42	journal	journal	PROPN
ecletica-1173	367	43	,	,	PUNCT
ecletica-1173	367	44	vol	vol	NOUN
ecletica-1173	367	45	.	.	PROPN
ecletica-1173	367	46	46	46	NUM
ecletica-1173	367	47	,	,	PUNCT
ecletica-1173	367	48	n.	n.	NOUN
ecletica-1173	367	49	3	3	NUM
ecletica-1173	367	50	,	,	PUNCT
ecletica-1173	367	51	2021	2021	NUM
ecletica-1173	367	52	,	,	PUNCT
ecletica-1173	367	53	17	17	NUM
ecletica-1173	367	54	-	-	SYM
ecletica-1173	367	55	32	32	NUM
ecletica-1173	367	56	issn	issn	NOUN
ecletica-1173	367	57	:	:	PUNCT
ecletica-1173	367	58	1678	1678	NUM
ecletica-1173	367	59	-	-	SYM
ecletica-1173	367	60	4618	4618	NUM
ecletica-1173	367	61	doi	doi	NOUN
ecletica-1173	367	62	:	:	PUNCT
ecletica-1173	367	63	10.26850/1678	10.26850/1678	NUM
ecletica-1173	367	64	-	-	SYM
ecletica-1173	367	65	4618eqj.v46.3.2021.p17	4618eqj.v46.3.2021.p17	NOUN
ecletica-1173	367	66	-	-	SYM
ecletica-1173	367	67	32	32	NUM
ecletica-1173	367	68	interaction	interaction	NOUN
ecletica-1173	367	69	that	that	PRON
ecletica-1173	367	70	happens	happen	VERB
ecletica-1173	367	71	between	between	ADP
ecletica-1173	367	72	cells	cell	NOUN
ecletica-1173	367	73	within	within	ADP
ecletica-1173	367	74	the	the	DET
ecletica-1173	367	75	stroma	stroma	NOUN
ecletica-1173	367	76	and	and	CCONJ
ecletica-1173	367	77	parenchyma	parenchyma	NOUN
ecletica-1173	367	78	of	of	ADP
ecletica-1173	367	79	an	an	DET
ecletica-1173	367	80	organ	organ	NOUN
ecletica-1173	367	81	.	.	PUNCT
ecletica-1173	368	1	for	for	ADP
ecletica-1173	368	2	toft	toft	ADJ
ecletica-1173	368	3	researchers	researcher	NOUN
ecletica-1173	368	4	,	,	PUNCT
ecletica-1173	368	5	the	the	DET
ecletica-1173	368	6	smt	smt	PROPN
ecletica-1173	368	7	program	program	NOUN
ecletica-1173	368	8	works	work	VERB
ecletica-1173	368	9	with	with	ADP
ecletica-1173	368	10	a	a	DET
ecletica-1173	368	11	reductionist	reductionist	ADJ
ecletica-1173	368	12	problem	problem	NOUN
ecletica-1173	368	13	,	,	PUNCT
ecletica-1173	368	14	because	because	SCONJ
ecletica-1173	368	15	it	it	PRON
ecletica-1173	368	16	looks	look	VERB
ecletica-1173	368	17	for	for	ADP
ecletica-1173	368	18	carcinogenesis	carcinogenesis	NOUN
ecletica-1173	368	19	caused	cause	VERB
ecletica-1173	368	20	at	at	ADP
ecletica-1173	368	21	the	the	DET
ecletica-1173	368	22	genes	gene	NOUN
ecletica-1173	368	23	and	and	CCONJ
ecletica-1173	368	24	molecular	molecular	ADJ
ecletica-1173	368	25	components	component	NOUN
ecletica-1173	368	26	level	level	NOUN
ecletica-1173	368	27	of	of	ADP
ecletica-1173	368	28	cells	cell	NOUN
ecletica-1173	368	29	instead	instead	ADV
ecletica-1173	368	30	of	of	ADP
ecletica-1173	368	31	the	the	DET
ecletica-1173	368	32	total	total	ADJ
ecletica-1173	368	33	level	level	NOUN
ecletica-1173	368	34	of	of	ADP
ecletica-1173	368	35	tissues	tissue	NOUN
ecletica-1173	368	36	:	:	PUNCT
ecletica-1173	368	37	cancer	cancer	NOUN
ecletica-1173	368	38	is	be	AUX
ecletica-1173	368	39	seen	see	VERB
ecletica-1173	368	40	as	as	ADP
ecletica-1173	368	41	an	an	DET
ecletica-1173	368	42	intracellular	intracellular	ADJ
ecletica-1173	368	43	problem	problem	NOUN
ecletica-1173	368	44	caused	cause	VERB
ecletica-1173	368	45	by	by	ADP
ecletica-1173	368	46	mutations	mutation	NOUN
ecletica-1173	368	47	within	within	ADP
ecletica-1173	368	48	the	the	DET
ecletica-1173	368	49	dna	dna	NOUN
ecletica-1173	368	50	of	of	ADP
ecletica-1173	368	51	the	the	DET
ecletica-1173	368	52	cancer	cancer	NOUN
ecletica-1173	368	53	cell	cell	NOUN
ecletica-1173	368	54	.	.	PUNCT
ecletica-1173	369	1	the	the	DET
ecletica-1173	369	2	basic	basic	ADJ
ecletica-1173	369	3	level	level	NOUN
ecletica-1173	369	4	that	that	SCONJ
ecletica-1173	369	5	carcinogenesis	carcinogenesis	NOUN
ecletica-1173	369	6	causes	cause	NOUN
ecletica-1173	369	7	ought	ought	AUX
ecletica-1173	369	8	to	to	PART
ecletica-1173	369	9	be	be	AUX
ecletica-1173	369	10	explored	explore	VERB
ecletica-1173	369	11	is	be	AUX
ecletica-1173	369	12	the	the	DET
ecletica-1173	369	13	tissue	tissue	NOUN
ecletica-1173	369	14	level	level	NOUN
ecletica-1173	369	15	,	,	PUNCT
ecletica-1173	369	16	because	because	SCONJ
ecletica-1173	369	17	this	this	DET
ecletica-1173	369	18	level	level	NOUN
ecletica-1173	369	19	is	be	AUX
ecletica-1173	369	20	used	use	VERB
ecletica-1173	369	21	in	in	ADP
ecletica-1173	369	22	biopsy	biopsy	NOUN
ecletica-1173	369	23	that	that	PRON
ecletica-1173	369	24	can	can	AUX
ecletica-1173	369	25	give	give	VERB
ecletica-1173	369	26	an	an	DET
ecletica-1173	369	27	authoritative	authoritative	ADJ
ecletica-1173	369	28	conclusion	conclusion	NOUN
ecletica-1173	369	29	of	of	ADP
ecletica-1173	369	30	cancer	cancer	NOUN
ecletica-1173	369	31	(	(	PUNCT
ecletica-1173	369	32	soto	soto	NOUN
ecletica-1173	369	33	and	and	CCONJ
ecletica-1173	369	34	sonnenschein	sonnenschein	ADJ
ecletica-1173	369	35	,	,	PUNCT
ecletica-1173	369	36	2005	2005	NUM
ecletica-1173	369	37	)	)	PUNCT
ecletica-1173	369	38	.	.	PUNCT
ecletica-1173	370	1	sonnenschein	sonnenschein	PROPN
ecletica-1173	370	2	and	and	CCONJ
ecletica-1173	370	3	soto	soto	PROPN
ecletica-1173	370	4	(	(	PUNCT
ecletica-1173	370	5	2020	2020	NUM
ecletica-1173	370	6	)	)	PUNCT
ecletica-1173	370	7	characterize	characterize	VERB
ecletica-1173	370	8	hereditary	hereditary	ADJ
ecletica-1173	370	9	reductionism	reductionism	NOUN
ecletica-1173	370	10	as	as	ADP
ecletica-1173	370	11	:	:	PUNCT
ecletica-1173	370	12	a	a	DET
ecletica-1173	370	13	great	great	ADJ
ecletica-1173	370	14	number	number	NOUN
ecletica-1173	370	15	of	of	ADP
ecletica-1173	370	16	biologists	biologist	NOUN
ecletica-1173	370	17	demand	demand	VERB
ecletica-1173	370	18	that	that	SCONJ
ecletica-1173	370	19	cancer	cancer	NOUN
ecletica-1173	370	20	clarifications	clarification	NOUN
ecletica-1173	370	21	should	should	AUX
ecletica-1173	370	22	be	be	AUX
ecletica-1173	370	23	analyzed	analyze	VERB
ecletica-1173	370	24	in	in	ADP
ecletica-1173	370	25	gene	gene	NOUN
ecletica-1173	370	26	or	or	CCONJ
ecletica-1173	370	27	gene	gene	NOUN
ecletica-1173	370	28	product	product	NOUN
ecletica-1173	370	29	level	level	NOUN
ecletica-1173	370	30	.	.	PUNCT
ecletica-1173	371	1	this	this	DET
ecletica-1173	371	2	reductionist	reductionist	ADJ
ecletica-1173	371	3	-	-	PUNCT
ecletica-1173	371	4	genetic	genetic	ADJ
ecletica-1173	371	5	predicts	predict	NOUN
ecletica-1173	371	6	that	that	SCONJ
ecletica-1173	371	7	everything	everything	PRON
ecletica-1173	371	8	in	in	ADP
ecletica-1173	371	9	biology	biology	NOUN
ecletica-1173	371	10	can	can	AUX
ecletica-1173	371	11	be	be	AUX
ecletica-1173	371	12	diminished	diminish	VERB
ecletica-1173	371	13	to	to	ADP
ecletica-1173	371	14	genes	gene	NOUN
ecletica-1173	371	15	since	since	SCONJ
ecletica-1173	371	16	the	the	DET
ecletica-1173	371	17	genome	genome	NOUN
ecletica-1173	371	18	is	be	AUX
ecletica-1173	371	19	the	the	DET
ecletica-1173	371	20	store	store	NOUN
ecletica-1173	371	21	of	of	ADP
ecletica-1173	371	22	transmissible	transmissible	ADJ
ecletica-1173	371	23	information	information	NOUN
ecletica-1173	371	24	.	.	PUNCT
ecletica-1173	372	1	the	the	DET
ecletica-1173	372	2	approach	approach	NOUN
ecletica-1173	372	3	taken	take	VERB
ecletica-1173	372	4	by	by	ADP
ecletica-1173	372	5	smt	smt	PROPN
ecletica-1173	372	6	is	be	AUX
ecletica-1173	372	7	exceptionally	exceptionally	ADV
ecletica-1173	372	8	prohibitive	prohibitive	ADJ
ecletica-1173	372	9	because	because	SCONJ
ecletica-1173	372	10	it	it	PRON
ecletica-1173	372	11	limits	limit	VERB
ecletica-1173	372	12	the	the	DET
ecletica-1173	372	13	issue	issue	NOUN
ecletica-1173	372	14	in	in	ADP
ecletica-1173	372	15	terms	term	NOUN
ecletica-1173	372	16	of	of	ADP
ecletica-1173	372	17	genes	gene	NOUN
ecletica-1173	372	18	and	and	CCONJ
ecletica-1173	372	19	molecular	molecular	ADJ
ecletica-1173	372	20	expressions	expression	NOUN
ecletica-1173	372	21	.	.	PUNCT
ecletica-1173	373	1	it	it	PRON
ecletica-1173	373	2	has	have	AUX
ecletica-1173	373	3	indeed	indeed	ADV
ecletica-1173	373	4	condemned	condemn	VERB
ecletica-1173	373	5	the	the	DET
ecletica-1173	373	6	cancer	cancer	NOUN
ecletica-1173	373	7	investigation	investigation	NOUN
ecletica-1173	373	8	.	.	PUNCT
ecletica-1173	374	1	for	for	ADP
ecletica-1173	374	2	this	this	DET
ecletica-1173	374	3	reason	reason	NOUN
ecletica-1173	374	4	,	,	PUNCT
ecletica-1173	374	5	this	this	DET
ecletica-1173	374	6	theory	theory	NOUN
ecletica-1173	374	7	should	should	AUX
ecletica-1173	374	8	be	be	AUX
ecletica-1173	374	9	eliminated	eliminate	VERB
ecletica-1173	374	10	or	or	CCONJ
ecletica-1173	374	11	supplanted	supplant	VERB
ecletica-1173	374	12	.	.	PUNCT
ecletica-1173	375	1	in	in	ADP
ecletica-1173	375	2	other	other	ADJ
ecletica-1173	375	3	words	word	NOUN
ecletica-1173	375	4	,	,	PUNCT
ecletica-1173	375	5	the	the	DET
ecletica-1173	375	6	smt	smt	PROPN
ecletica-1173	375	7	approach	approach	NOUN
ecletica-1173	375	8	is	be	AUX
ecletica-1173	375	9	criticized	criticize	VERB
ecletica-1173	375	10	to	to	PART
ecletica-1173	375	11	reduce	reduce	VERB
ecletica-1173	375	12	the	the	DET
ecletica-1173	375	13	cancer	cancer	NOUN
ecletica-1173	375	14	to	to	ADP
ecletica-1173	375	15	genes	gene	NOUN
ecletica-1173	375	16	and	and	CCONJ
ecletica-1173	375	17	particles	particle	NOUN
ecletica-1173	375	18	inside	inside	ADP
ecletica-1173	375	19	cells	cell	NOUN
ecletica-1173	375	20	.	.	PUNCT
ecletica-1173	376	1	this	this	DET
ecletica-1173	376	2	approach	approach	NOUN
ecletica-1173	376	3	will	will	AUX
ecletica-1173	376	4	inhibit	inhibit	VERB
ecletica-1173	376	5	the	the	DET
ecletica-1173	376	6	exam	exam	NOUN
ecletica-1173	376	7	of	of	ADP
ecletica-1173	376	8	other	other	ADJ
ecletica-1173	376	9	potential	potential	ADJ
ecletica-1173	376	10	causes	cause	NOUN
ecletica-1173	376	11	,	,	PUNCT
ecletica-1173	376	12	such	such	ADJ
ecletica-1173	376	13	as	as	ADP
ecletica-1173	376	14	tissue	tissue	NOUN
ecletica-1173	376	15	organization	organization	NOUN
ecletica-1173	376	16	.	.	PUNCT
ecletica-1173	377	1	as	as	ADP
ecletica-1173	377	2	a	a	DET
ecletica-1173	377	3	substitute	substitute	NOUN
ecletica-1173	377	4	for	for	ADP
ecletica-1173	377	5	hereditary	hereditary	ADJ
ecletica-1173	377	6	reductionism	reductionism	NOUN
ecletica-1173	377	7	,	,	PUNCT
ecletica-1173	377	8	toft	toft	PROPN
ecletica-1173	377	9	proposes	propose	VERB
ecletica-1173	377	10	an	an	DET
ecletica-1173	377	11	approach	approach	NOUN
ecletica-1173	377	12	based	base	VERB
ecletica-1173	377	13	on	on	ADP
ecletica-1173	377	14	organicism	organicism	NOUN
ecletica-1173	377	15	:	:	PUNCT
ecletica-1173	377	16	cancer	cancer	NOUN
ecletica-1173	377	17	is	be	AUX
ecletica-1173	377	18	seen	see	VERB
ecletica-1173	377	19	as	as	ADP
ecletica-1173	377	20	an	an	DET
ecletica-1173	377	21	issue	issue	NOUN
ecletica-1173	377	22	comparable	comparable	ADJ
ecletica-1173	377	23	to	to	ADP
ecletica-1173	377	24	histogenesis	histogenesis	NOUN
ecletica-1173	377	25	or	or	CCONJ
ecletica-1173	377	26	organogenesis	organogenesis	NOUN
ecletica-1173	377	27	and	and	CCONJ
ecletica-1173	377	28	is	be	AUX
ecletica-1173	377	29	hence	hence	ADV
ecletica-1173	377	30	a	a	DET
ecletica-1173	377	31	developmental	developmental	ADJ
ecletica-1173	377	32	science	science	NOUN
ecletica-1173	377	33	.	.	PUNCT
ecletica-1173	378	1	organicists	organicist	VERB
ecletica-1173	378	2	“	"	PUNCT
ecletica-1173	378	3	select	select	ADJ
ecletica-1173	378	4	to	to	ADP
ecletica-1173	378	5	work	work	VERB
ecletica-1173	378	6	”	"	PUNCT
ecletica-1173	378	7	at	at	ADP
ecletica-1173	378	8	the	the	DET
ecletica-1173	378	9	level	level	NOUN
ecletica-1173	378	10	of	of	ADP
ecletica-1173	378	11	organization	organization	NOUN
ecletica-1173	378	12	at	at	ADP
ecletica-1173	378	13	which	which	PRON
ecletica-1173	378	14	the	the	DET
ecletica-1173	378	15	phenomenon	phenomenon	NOUN
ecletica-1173	378	16	is	be	AUX
ecletica-1173	378	17	observed	observe	VERB
ecletica-1173	378	18	.	.	PUNCT
ecletica-1173	379	1	the	the	DET
ecletica-1173	379	2	toft	toft	NOUN
ecletica-1173	379	3	cautiously	cautiously	ADV
ecletica-1173	379	4	wanders	wander	VERB
ecletica-1173	379	5	into	into	ADP
ecletica-1173	379	6	lower	low	ADJ
ecletica-1173	379	7	levels	level	NOUN
ecletica-1173	379	8	of	of	ADP
ecletica-1173	379	9	organization	organization	NOUN
ecletica-1173	379	10	,	,	PUNCT
ecletica-1173	379	11	slowly	slowly	ADV
ecletica-1173	379	12	moving	move	VERB
ecletica-1173	379	13	through	through	ADP
ecletica-1173	379	14	the	the	DET
ecletica-1173	379	15	different	different	ADJ
ecletica-1173	379	16	various	various	ADJ
ecletica-1173	379	17	levels	level	NOUN
ecletica-1173	379	18	in	in	ADP
ecletica-1173	379	19	which	which	PRON
ecletica-1173	379	20	the	the	DET
ecletica-1173	379	21	phenomenon	phenomenon	NOUN
ecletica-1173	379	22	is	be	AUX
ecletica-1173	379	23	observed	observe	VERB
ecletica-1173	379	24	.	.	PUNCT
ecletica-1173	380	1	8.1	8.1	NUM
ecletica-1173	380	2	systems	system	NOUN
ecletica-1173	380	3	biology	biology	NOUN
ecletica-1173	380	4	the	the	DET
ecletica-1173	380	5	objective	objective	NOUN
ecletica-1173	380	6	of	of	ADP
ecletica-1173	380	7	systems	system	NOUN
ecletica-1173	380	8	biology	biology	NOUN
ecletica-1173	380	9	is	be	AUX
ecletica-1173	380	10	to	to	PART
ecletica-1173	380	11	consider	consider	VERB
ecletica-1173	380	12	the	the	DET
ecletica-1173	380	13	physiological	physiological	ADJ
ecletica-1173	380	14	and	and	CCONJ
ecletica-1173	380	15	conditions	condition	NOUN
ecletica-1173	380	16	of	of	ADP
ecletica-1173	380	17	administrative	administrative	ADJ
ecletica-1173	380	18	arrangement	arrangement	NOUN
ecletica-1173	380	19	levels	level	NOUN
ecletica-1173	380	20	,	,	PUNCT
ecletica-1173	380	21	signaling	signal	VERB
ecletica-1173	380	22	pathways	pathway	NOUN
ecletica-1173	380	23	,	,	PUNCT
ecletica-1173	380	24	cells	cell	NOUN
ecletica-1173	380	25	,	,	PUNCT
ecletica-1173	380	26	tissue	tissue	NOUN
ecletica-1173	380	27	,	,	PUNCT
ecletica-1173	380	28	organs	organ	NOUN
ecletica-1173	380	29	,	,	PUNCT
ecletica-1173	380	30	and	and	CCONJ
ecletica-1173	380	31	inevitably	inevitably	ADV
ecletica-1173	380	32	the	the	DET
ecletica-1173	380	33	whole	whole	ADJ
ecletica-1173	380	34	life	life	NOUN
ecletica-1173	380	35	form	form	NOUN
ecletica-1173	380	36	(	(	PUNCT
ecletica-1173	380	37	berg	berg	PROPN
ecletica-1173	380	38	,	,	PUNCT
ecletica-1173	380	39	2014	2014	NUM
ecletica-1173	380	40	)	)	PUNCT
ecletica-1173	380	41	.	.	PUNCT
ecletica-1173	381	1	it	it	PRON
ecletica-1173	381	2	is	be	AUX
ecletica-1173	381	3	a	a	DET
ecletica-1173	381	4	holistic	holistic	ADJ
ecletica-1173	381	5	view	view	NOUN
ecletica-1173	381	6	based	base	VERB
ecletica-1173	381	7	in	in	ADP
ecletica-1173	381	8	some	some	DET
ecletica-1173	381	9	methodological	methodological	ADJ
ecletica-1173	381	10	reductionism	reductionism	NOUN
ecletica-1173	381	11	to	to	PART
ecletica-1173	381	12	compute	compute	VERB
ecletica-1173	381	13	the	the	DET
ecletica-1173	381	14	properties	property	NOUN
ecletica-1173	381	15	that	that	PRON
ecletica-1173	381	16	will	will	AUX
ecletica-1173	381	17	integrate	integrate	VERB
ecletica-1173	381	18	the	the	DET
ecletica-1173	381	19	whole	whole	NOUN
ecletica-1173	381	20	.	.	PUNCT
ecletica-1173	382	1	the	the	DET
ecletica-1173	382	2	structure	structure	NOUN
ecletica-1173	382	3	of	of	ADP
ecletica-1173	382	4	science	science	NOUN
ecletica-1173	382	5	comprises	comprise	VERB
ecletica-1173	382	6	a	a	DET
ecletica-1173	382	7	number	number	NOUN
ecletica-1173	382	8	of	of	ADP
ecletica-1173	382	9	approaches	approach	NOUN
ecletica-1173	382	10	and	and	CCONJ
ecletica-1173	382	11	models	model	NOUN
ecletica-1173	382	12	that	that	PRON
ecletica-1173	382	13	help	help	VERB
ecletica-1173	382	14	within	within	ADP
ecletica-1173	382	15	the	the	DET
ecletica-1173	382	16	consideration	consideration	NOUN
ecletica-1173	382	17	of	of	ADP
ecletica-1173	382	18	the	the	DET
ecletica-1173	382	19	organic	organic	ADJ
ecletica-1173	382	20	complexity	complexity	NOUN
ecletica-1173	382	21	of	of	ADP
ecletica-1173	382	22	different	different	ADJ
ecletica-1173	382	23	illnesses	illness	NOUN
ecletica-1173	382	24	.	.	PUNCT
ecletica-1173	383	1	system	system	NOUN
ecletica-1173	383	2	biology	biology	NOUN
ecletica-1173	383	3	combines	combine	VERB
ecletica-1173	383	4	an	an	DET
ecletica-1173	383	5	expansive	expansive	ADJ
ecletica-1173	383	6	sum	sum	NOUN
ecletica-1173	383	7	of	of	ADP
ecletica-1173	383	8	reductionist	reductionist	ADJ
ecletica-1173	383	9	genomic	genomic	NOUN
ecletica-1173	383	10	information	information	NOUN
ecletica-1173	383	11	,	,	PUNCT
ecletica-1173	383	12	proteomic	proteomic	NOUN
ecletica-1173	383	13	and	and	CCONJ
ecletica-1173	383	14	metabolomic	metabolomic	ADJ
ecletica-1173	383	15	tests	test	NOUN
ecletica-1173	383	16	to	to	PART
ecletica-1173	383	17	produce	produce	VERB
ecletica-1173	383	18	an	an	DET
ecletica-1173	383	19	organized	organize	VERB
ecletica-1173	383	20	data	datum	NOUN
ecletica-1173	383	21	set	set	VERB
ecletica-1173	383	22	for	for	ADP
ecletica-1173	383	23	considering	consider	VERB
ecletica-1173	383	24	a	a	DET
ecletica-1173	383	25	disease	disease	NOUN
ecletica-1173	383	26	.	.	PUNCT
ecletica-1173	384	1	system	system	NOUN
ecletica-1173	384	2	biology	biology	NOUN
ecletica-1173	384	3	points	point	VERB
ecletica-1173	384	4	to	to	ADP
ecletica-1173	384	5	the	the	DET
ecletica-1173	384	6	complex	complex	ADJ
ecletica-1173	384	7	behavior	behavior	NOUN
ecletica-1173	384	8	of	of	ADP
ecletica-1173	384	9	organic	organic	ADJ
ecletica-1173	384	10	frameworks	framework	NOUN
ecletica-1173	384	11	that	that	PRON
ecletica-1173	384	12	develop	develop	VERB
ecletica-1173	384	13	from	from	ADP
ecletica-1173	384	14	personal	personal	ADJ
ecletica-1173	384	15	framework	framework	NOUN
ecletica-1173	384	16	components	component	NOUN
ecletica-1173	384	17	and	and	CCONJ
ecletica-1173	384	18	intelligence	intelligence	NOUN
ecletica-1173	384	19	between	between	ADP
ecletica-1173	384	20	them	they	PRON
ecletica-1173	384	21	(	(	PUNCT
ecletica-1173	384	22	sobie	sobie	PROPN
ecletica-1173	384	23	et	et	PROPN
ecletica-1173	384	24	al	al	PROPN
ecletica-1173	384	25	.	.	PROPN
ecletica-1173	384	26	,	,	PUNCT
ecletica-1173	384	27	2011	2011	NUM
ecletica-1173	384	28	)	)	PUNCT
ecletica-1173	384	29	.	.	PUNCT
ecletica-1173	385	1	hence	hence	ADV
ecletica-1173	385	2	,	,	PUNCT
ecletica-1173	385	3	a	a	DET
ecletica-1173	385	4	fundamental	fundamental	ADJ
ecletica-1173	385	5	highlight	highlight	NOUN
ecletica-1173	385	6	of	of	ADP
ecletica-1173	385	7	system	system	NOUN
ecletica-1173	385	8	biology	biology	NOUN
ecletica-1173	385	9	is	be	AUX
ecletica-1173	385	10	that	that	SCONJ
ecletica-1173	385	11	the	the	DET
ecletica-1173	385	12	interaction	interaction	NOUN
ecletica-1173	385	13	between	between	ADP
ecletica-1173	385	14	all	all	DET
ecletica-1173	385	15	framework	framework	NOUN
ecletica-1173	385	16	components	component	NOUN
ecletica-1173	385	17	is	be	AUX
ecletica-1173	385	18	examined	examine	VERB
ecletica-1173	385	19	instead	instead	ADV
ecletica-1173	385	20	of	of	ADP
ecletica-1173	385	21	the	the	DET
ecletica-1173	385	22	characteristics	characteristic	NOUN
ecletica-1173	385	23	of	of	ADP
ecletica-1173	385	24	each	each	DET
ecletica-1173	385	25	individual	individual	ADJ
ecletica-1173	385	26	component	component	NOUN
ecletica-1173	385	27	.	.	PUNCT
ecletica-1173	386	1	it	it	PRON
ecletica-1173	386	2	gives	give	VERB
ecletica-1173	386	3	a	a	DET
ecletica-1173	386	4	few	few	ADJ
ecletica-1173	386	5	approaches	approach	NOUN
ecletica-1173	386	6	to	to	ADP
ecletica-1173	386	7	creating	create	VERB
ecletica-1173	386	8	forecasts	forecast	NOUN
ecletica-1173	386	9	that	that	PRON
ecletica-1173	386	10	can	can	AUX
ecletica-1173	386	11	be	be	AUX
ecletica-1173	386	12	tested	test	VERB
ecletica-1173	386	13	experimentally	experimentally	ADV
ecletica-1173	386	14	.	.	PUNCT
ecletica-1173	387	1	system	system	NOUN
ecletica-1173	387	2	biology	biology	NOUN
ecletica-1173	387	3	depends	depend	VERB
ecletica-1173	387	4	on	on	ADP
ecletica-1173	387	5	the	the	DET
ecletica-1173	387	6	combination	combination	NOUN
ecletica-1173	387	7	of	of	ADP
ecletica-1173	387	8	test	test	NOUN
ecletica-1173	387	9	ponders	ponder	NOUN
ecletica-1173	387	10	,	,	PUNCT
ecletica-1173	387	11	that	that	PRON
ecletica-1173	387	12	creates	create	VERB
ecletica-1173	387	13	information	information	NOUN
ecletica-1173	387	14	concerning	concern	VERB
ecletica-1173	387	15	cellular	cellular	ADJ
ecletica-1173	387	16	components	component	NOUN
ecletica-1173	387	17	of	of	ADP
ecletica-1173	387	18	a	a	DET
ecletica-1173	387	19	framework	framework	NOUN
ecletica-1173	387	20	as	as	ADV
ecletica-1173	387	21	well	well	ADV
ecletica-1173	387	22	as	as	ADP
ecletica-1173	387	23	approaches	approach	NOUN
ecletica-1173	387	24	that	that	PRON
ecletica-1173	387	25	help	help	VERB
ecletica-1173	387	26	within	within	ADP
ecletica-1173	387	27	the	the	DET
ecletica-1173	387	28	examination	examination	NOUN
ecletica-1173	387	29	of	of	ADP
ecletica-1173	387	30	different	different	ADJ
ecletica-1173	387	31	information	information	NOUN
ecletica-1173	387	32	sets	set	NOUN
ecletica-1173	387	33	.	.	PUNCT
ecletica-1173	388	1	two	two	NUM
ecletica-1173	388	2	major	major	ADJ
ecletica-1173	388	3	computational	computational	ADJ
ecletica-1173	388	4	approaches	approach	NOUN
ecletica-1173	388	5	are	be	AUX
ecletica-1173	388	6	utilized	utilize	VERB
ecletica-1173	388	7	in	in	ADP
ecletica-1173	388	8	system	system	NOUN
ecletica-1173	388	9	biology	biology	NOUN
ecletica-1173	388	10	,	,	PUNCT
ecletica-1173	388	11	specifically	specifically	ADV
ecletica-1173	388	12	,	,	PUNCT
ecletica-1173	388	13	data	datum	NOUN
ecletica-1173	388	14	oriented	orient	VERB
ecletica-1173	388	15	(	(	PUNCT
ecletica-1173	388	16	top	top	ADJ
ecletica-1173	388	17	-	-	PUNCT
ecletica-1173	388	18	down	down	ADP
ecletica-1173	388	19	approach	approach	NOUN
ecletica-1173	388	20	)	)	PUNCT
ecletica-1173	388	21	and	and	CCONJ
ecletica-1173	388	22	hypothesis	hypothesis	NOUN
ecletica-1173	388	23	driven	drive	VERB
ecletica-1173	388	24	(	(	PUNCT
ecletica-1173	388	25	bottom	bottom	ADJ
ecletica-1173	388	26	-	-	PUNCT
ecletica-1173	388	27	up	up	ADP
ecletica-1173	388	28	approach	approach	NOUN
ecletica-1173	388	29	)	)	PUNCT
ecletica-1173	388	30	(	(	PUNCT
ecletica-1173	388	31	faratian	faratian	PROPN
ecletica-1173	388	32	et	et	PROPN
ecletica-1173	388	33	al	al	PROPN
ecletica-1173	388	34	.	.	PROPN
ecletica-1173	388	35	,	,	PUNCT
ecletica-1173	388	36	20093	20093	NUM
ecletica-1173	388	37	)	)	PUNCT
ecletica-1173	388	38	to	to	PART
ecletica-1173	388	39	create	create	VERB
ecletica-1173	388	40	new	new	ADJ
ecletica-1173	388	41	treatments	treatment	NOUN
ecletica-1173	388	42	.	.	PUNCT
ecletica-1173	389	1	8.2	8.2	NUM
ecletica-1173	389	2	predicting	predict	VERB
ecletica-1173	389	3	drug	drug	NOUN
ecletica-1173	389	4	-	-	PUNCT
ecletica-1173	389	5	target	target	NOUN
ecletica-1173	389	6	interactions	interaction	NOUN
ecletica-1173	389	7	(	(	PUNCT
ecletica-1173	389	8	dti	dti	PROPN
ecletica-1173	389	9	)	)	PUNCT
ecletica-1173	389	10	drugs	drug	NOUN
ecletica-1173	389	11	often	often	ADV
ecletica-1173	389	12	bind	bind	VERB
ecletica-1173	389	13	to	to	ADP
ecletica-1173	389	14	more	more	ADJ
ecletica-1173	389	15	than	than	ADP
ecletica-1173	389	16	one	one	NUM
ecletica-1173	389	17	biomolecular	biomolecular	ADJ
ecletica-1173	389	18	target	target	NOUN
ecletica-1173	389	19	.	.	PUNCT
ecletica-1173	390	1	it	it	PRON
ecletica-1173	390	2	is	be	AUX
ecletica-1173	390	3	fundamental	fundamental	ADJ
ecletica-1173	390	4	to	to	PART
ecletica-1173	390	5	get	get	VERB
ecletica-1173	390	6	the	the	DET
ecletica-1173	390	7	polypharmacology	polypharmacology	NOUN
ecletica-1173	390	8	of	of	ADP
ecletica-1173	390	9	a	a	DET
ecletica-1173	390	10	medicament	medicament	NOUN
ecletica-1173	390	11	.	.	PUNCT
ecletica-1173	391	1	exploratory	exploratory	ADJ
ecletica-1173	391	2	approaches	approach	NOUN
ecletica-1173	391	3	to	to	PART
ecletica-1173	391	4	identify	identify	VERB
ecletica-1173	391	5	dti	dti	PROPN
ecletica-1173	391	6	are	be	AUX
ecletica-1173	391	7	costly	costly	ADJ
ecletica-1173	391	8	,	,	PUNCT
ecletica-1173	391	9	difficult	difficult	ADJ
ecletica-1173	391	10	,	,	PUNCT
ecletica-1173	391	11	and	and	CCONJ
ecletica-1173	391	12	time	time	NOUN
ecletica-1173	391	13	expending	expend	VERB
ecletica-1173	391	14	.	.	PUNCT
ecletica-1173	392	1	hence	hence	ADV
ecletica-1173	392	2	,	,	PUNCT
ecletica-1173	392	3	computational	computational	ADJ
ecletica-1173	392	4	approaches	approach	NOUN
ecletica-1173	392	5	are	be	AUX
ecletica-1173	392	6	broadly	broadly	ADV
ecletica-1173	392	7	used	use	VERB
ecletica-1173	392	8	for	for	ADP
ecletica-1173	392	9	dti	dti	PROPN
ecletica-1173	392	10	expectation	expectation	NOUN
ecletica-1173	392	11	.	.	PUNCT
ecletica-1173	393	1	computational	computational	ADJ
ecletica-1173	393	2	approaches	approach	NOUN
ecletica-1173	393	3	characterize	characterize	VERB
ecletica-1173	393	4	each	each	DET
ecletica-1173	393	5	target	target	NOUN
ecletica-1173	393	6	by	by	ADP
ecletica-1173	393	7	a	a	DET
ecletica-1173	393	8	set	set	NOUN
ecletica-1173	393	9	of	of	ADP
ecletica-1173	393	10	known	know	VERB
ecletica-1173	393	11	connection	connection	NOUN
ecletica-1173	393	12	covers	cover	NOUN
ecletica-1173	393	13	,	,	PUNCT
ecletica-1173	393	14	searching	search	VERB
ecletica-1173	393	15	for	for	ADP
ecletica-1173	393	16	chemically	chemically	ADV
ecletica-1173	393	17	organized	organize	VERB
ecletica-1173	393	18	drugs	drug	NOUN
ecletica-1173	393	19	anticipating	anticipate	VERB
ecletica-1173	393	20	modern	modern	ADJ
ecletica-1173	393	21	dtis	dtis	NOUN
ecletica-1173	393	22	(	(	PUNCT
ecletica-1173	393	23	keiser	keiser	PROPN
ecletica-1173	393	24	et	et	PROPN
ecletica-1173	393	25	al	al	PROPN
ecletica-1173	393	26	.	.	PROPN
ecletica-1173	393	27	2009	2009	NUM
ecletica-1173	393	28	)	)	PUNCT
ecletica-1173	393	29	.	.	PUNCT
ecletica-1173	394	1	associations	association	NOUN
ecletica-1173	394	2	between	between	ADP
ecletica-1173	394	3	drugs	drug	NOUN
ecletica-1173	394	4	and	and	CCONJ
ecletica-1173	394	5	targets	target	NOUN
ecletica-1173	394	6	can	can	AUX
ecletica-1173	394	7	be	be	AUX
ecletica-1173	394	8	anticipated	anticipate	VERB
ecletica-1173	394	9	based	base	VERB
ecletica-1173	394	10	on	on	ADP
ecletica-1173	394	11	the	the	DET
ecletica-1173	394	12	chemical	chemical	NOUN
ecletica-1173	394	13	structure	structure	NOUN
ecletica-1173	394	14	of	of	ADP
ecletica-1173	394	15	the	the	DET
ecletica-1173	394	16	drug	drug	NOUN
ecletica-1173	394	17	and	and	CCONJ
ecletica-1173	394	18	protein	protein	NOUN
ecletica-1173	394	19	sequence	sequence	NOUN
ecletica-1173	394	20	(	(	PUNCT
ecletica-1173	394	21	li	li	PROPN
ecletica-1173	394	22	et	et	PROPN
ecletica-1173	394	23	al	al	PROPN
ecletica-1173	394	24	.	.	PROPN
ecletica-1173	394	25	,	,	PUNCT
ecletica-1173	394	26	2015	2015	NUM
ecletica-1173	394	27	;	;	PUNCT
ecletica-1173	394	28	2017	2017	NUM
ecletica-1173	394	29	)	)	PUNCT
ecletica-1173	394	30	.	.	PUNCT
ecletica-1173	395	1	drug	drug	NOUN
ecletica-1173	395	2	-	-	PUNCT
ecletica-1173	395	3	target	target	NOUN
ecletica-1173	395	4	interactions	interaction	NOUN
ecletica-1173	395	5	can	can	AUX
ecletica-1173	395	6	moreover	moreover	ADV
ecletica-1173	395	7	be	be	AUX
ecletica-1173	395	8	distinguished	distinguish	VERB
ecletica-1173	395	9	based	base	VERB
ecletica-1173	395	10	on	on	ADP
ecletica-1173	395	11	similitudes	similitude	NOUN
ecletica-1173	395	12	of	of	ADP
ecletica-1173	395	13	side	side	NOUN
ecletica-1173	395	14	impacts	impact	NOUN
ecletica-1173	395	15	,	,	PUNCT
ecletica-1173	395	16	i.e.	i.e.	X
ecletica-1173	395	17	,	,	PUNCT
ecletica-1173	395	18	drugs	drug	NOUN
ecletica-1173	395	19	with	with	ADP
ecletica-1173	395	20	comparable	comparable	ADJ
ecletica-1173	395	21	side	side	NOUN
ecletica-1173	395	22	impacts	impact	NOUN
ecletica-1173	395	23	tend	tend	VERB
ecletica-1173	395	24	to	to	PART
ecletica-1173	395	25	be	be	AUX
ecletica-1173	395	26	associated	associate	VERB
ecletica-1173	395	27	with	with	ADP
ecletica-1173	395	28	the	the	DET
ecletica-1173	395	29	same	same	ADJ
ecletica-1173	395	30	biological	biological	ADJ
ecletica-1173	395	31	targets	target	NOUN
ecletica-1173	395	32	(	(	PUNCT
ecletica-1173	395	33	berg	berg	PROPN
ecletica-1173	395	34	,	,	PUNCT
ecletica-1173	395	35	2014	2014	NUM
ecletica-1173	395	36	;	;	PUNCT
ecletica-1173	395	37	campillos	campillo	VERB
ecletica-1173	395	38	et	et	PROPN
ecletica-1173	395	39	al	al	PROPN
ecletica-1173	395	40	.	.	PROPN
ecletica-1173	395	41	,	,	PUNCT
ecletica-1173	395	42	2008	2008	NUM
ecletica-1173	395	43	)	)	PUNCT
ecletica-1173	395	44	.	.	PUNCT
ecletica-1173	396	1	the	the	DET
ecletica-1173	396	2	combination	combination	NOUN
ecletica-1173	396	3	of	of	ADP
ecletica-1173	396	4	pharmacogenomic	pharmacogenomic	ADJ
ecletica-1173	396	5	likenesses	likeness	NOUN
ecletica-1173	396	6	and	and	CCONJ
ecletica-1173	396	7	side	side	NOUN
ecletica-1173	396	8	impacts	impact	NOUN
ecletica-1173	396	9	are	be	AUX
ecletica-1173	396	10	used	use	VERB
ecletica-1173	396	11	in	in	ADP
ecletica-1173	396	12	dti	dti	PROPN
ecletica-1173	396	13	(	(	PUNCT
ecletica-1173	396	14	li	li	PROPN
ecletica-1173	396	15	et	et	PROPN
ecletica-1173	396	16	al	al	PROPN
ecletica-1173	396	17	.	.	PROPN
ecletica-1173	396	18	,	,	PUNCT
ecletica-1173	396	19	2017	2017	NUM
ecletica-1173	396	20	)	)	PUNCT
ecletica-1173	396	21	.	.	PUNCT
ecletica-1173	397	1	in	in	ADP
ecletica-1173	397	2	addition	addition	NOUN
ecletica-1173	397	3	,	,	PUNCT
ecletica-1173	397	4	a	a	DET
ecletica-1173	397	5	comparison	comparison	NOUN
ecletica-1173	397	6	of	of	ADP
ecletica-1173	397	7	three	three	NUM
ecletica-1173	397	8	administered	administer	VERB
ecletica-1173	397	9	induction	induction	NOUN
ecletica-1173	397	10	strategies	strategy	NOUN
ecletica-1173	397	11	to	to	PART
ecletica-1173	397	12	anticipate	anticipate	VERB
ecletica-1173	397	13	dti	dti	PROPN
ecletica-1173	397	14	is	be	AUX
ecletica-1173	397	15	the	the	DET
ecletica-1173	397	16	induction	induction	NOUN
ecletica-1173	397	17	likeness	likeness	NOUN
ecletica-1173	397	18	,	,	PUNCT
ecletica-1173	397	19	target	target	NOUN
ecletica-1173	397	20	-	-	PUNCT
ecletica-1173	397	21	based	base	VERB
ecletica-1173	397	22	likeness	likeness	NOUN
ecletica-1173	397	23	deduction	deduction	NOUN
ecletica-1173	397	24	,	,	PUNCT
ecletica-1173	397	25	and	and	CCONJ
ecletica-1173	397	26	network	network	PROPN
ecletica-1173	397	27	-	-	PUNCT
ecletica-1173	397	28	b.	b.	PROPN
ecletica-1173	397	29	complex	complex	ADJ
ecletica-1173	397	30	diseases	disease	NOUN
ecletica-1173	397	31	are	be	AUX
ecletica-1173	397	32	controlled	control	VERB
ecletica-1173	397	33	by	by	ADP
ecletica-1173	397	34	the	the	DET
ecletica-1173	397	35	interconnected	interconnected	ADJ
ecletica-1173	397	36	systems	system	NOUN
ecletica-1173	397	37	of	of	ADP
ecletica-1173	397	38	numerous	numerous	ADJ
ecletica-1173	397	39	pathways	pathway	NOUN
ecletica-1173	397	40	related	relate	VERB
ecletica-1173	397	41	to	to	ADP
ecletica-1173	397	42	cell	cell	NOUN
ecletica-1173	397	43	expansion	expansion	NOUN
ecletica-1173	397	44	,	,	PUNCT
ecletica-1173	397	45	attack	attack	NOUN
ecletica-1173	397	46	and	and	CCONJ
ecletica-1173	397	47	medicate	medicate	VERB
ecletica-1173	397	48	resistance	resistance	NOUN
ecletica-1173	397	49	(	(	PUNCT
ecletica-1173	397	50	ryall	ryall	NOUN
ecletica-1173	397	51	and	and	CCONJ
ecletica-1173	397	52	tan	tan	PROPN
ecletica-1173	397	53	,	,	PUNCT
ecletica-1173	397	54	2015	2015	NUM
ecletica-1173	397	55	)	)	PUNCT
ecletica-1173	397	56	.	.	PUNCT
ecletica-1173	398	1	in	in	ADP
ecletica-1173	398	2	this	this	DET
ecletica-1173	398	3	way	way	NOUN
ecletica-1173	398	4	,	,	PUNCT
ecletica-1173	398	5	it	it	PRON
ecletica-1173	398	6	is	be	AUX
ecletica-1173	398	7	troublesome	troublesome	ADJ
ecletica-1173	398	8	to	to	PART
ecletica-1173	398	9	create	create	VERB
ecletica-1173	398	10	modern	modern	ADJ
ecletica-1173	398	11	treatments	treatment	NOUN
ecletica-1173	398	12	against	against	ADP
ecletica-1173	398	13	complex	complex	ADJ
ecletica-1173	398	14	infections	infection	NOUN
ecletica-1173	398	15	.	.	PUNCT
ecletica-1173	399	1	drugtarget	drugtarget	NOUN
ecletica-1173	399	2	interactions	interaction	NOUN
ecletica-1173	399	3	approach	approach	NOUN
ecletica-1173	399	4	uses	use	VERB
ecletica-1173	399	5	a	a	DET
ecletica-1173	399	6	combination	combination	NOUN
ecletica-1173	399	7	of	of	ADP
ecletica-1173	399	8	medicating	medicate	VERB
ecletica-1173	399	9	treatments	treatment	NOUN
ecletica-1173	399	10	that	that	SCONJ
ecletica-1173	399	11	at	at	ADP
ecletica-1173	399	12	the	the	DET
ecletica-1173	399	13	same	same	ADJ
ecletica-1173	399	14	time	time	NOUN
ecletica-1173	399	15	balance	balance	NOUN
ecletica-1173	399	16	numerous	numerous	ADJ
ecletica-1173	399	17	targets	target	NOUN
ecletica-1173	399	18	and	and	CCONJ
ecletica-1173	399	19	may	may	AUX
ecletica-1173	399	20	have	have	VERB
ecletica-1173	399	21	more	more	ADJ
ecletica-1173	399	22	advantages	advantage	NOUN
ecletica-1173	399	23	than	than	ADP
ecletica-1173	399	24	employing	employ	VERB
ecletica-1173	399	25	a	a	DET
ecletica-1173	399	26	single	single	ADJ
ecletica-1173	399	27	drug	drug	NOUN
ecletica-1173	399	28	(	(	PUNCT
ecletica-1173	399	29	jia	jia	PROPN
ecletica-1173	399	30	et	et	PROPN
ecletica-1173	399	31	al	al	PROPN
ecletica-1173	399	32	.	.	PROPN
ecletica-1173	399	33	,	,	PUNCT
ecletica-1173	399	34	2009	2009	NUM
ecletica-1173	399	35	)	)	PUNCT
ecletica-1173	399	36	.	.	PUNCT
ecletica-1173	400	1	this	this	DET
ecletica-1173	400	2	approach	approach	NOUN
ecletica-1173	400	3	gives	give	VERB
ecletica-1173	400	4	strong	strong	ADJ
ecletica-1173	400	5	evidence	evidence	NOUN
ecletica-1173	400	6	for	for	ADP
ecletica-1173	400	7	anticipating	anticipate	VERB
ecletica-1173	400	8	treatments	treatment	NOUN
ecletica-1173	400	9	of	of	ADP
ecletica-1173	400	10	an	an	DET
ecletica-1173	400	11	infection	infection	NOUN
ecletica-1173	400	12	.	.	PUNCT
ecletica-1173	401	1	a	a	DET
ecletica-1173	401	2	few	few	ADJ
ecletica-1173	401	3	network	network	NOUN
ecletica-1173	401	4	-	-	PUNCT
ecletica-1173	401	5	based	base	VERB
ecletica-1173	401	6	approaches	approach	NOUN
ecletica-1173	401	7	have	have	AUX
ecletica-1173	401	8	been	be	AUX
ecletica-1173	401	9	employed	employ	VERB
ecletica-1173	401	10	to	to	PART
ecletica-1173	401	11	anticipate	anticipate	VERB
ecletica-1173	401	12	drug	drug	NOUN
ecletica-1173	401	13	http://revista.iq.unesp.br/ojs/index.php/ecletica/index	http://revista.iq.unesp.br/ojs/index.php/ecletica/index	PROPN
ecletica-1173	401	14	https://doi.org/10.26850/1678-4618eqj.v46.3.2021.p17-32	https://doi.org/10.26850/1678-4618eqj.v46.3.2021.p17-32	PROPN
ecletica-1173	401	15	review	review	NOUN
ecletica-1173	401	16	article	article	NOUN
ecletica-1173	401	17	iq.unesp.br/ecletica	iq.unesp.br/ecletica	PROPN
ecletica-1173	401	18	28	28	NUM
ecletica-1173	401	19	eclética	eclética	PROPN
ecletica-1173	401	20	química	química	PROPN
ecletica-1173	401	21	journal	journal	PROPN
ecletica-1173	401	22	,	,	PUNCT
ecletica-1173	401	23	vol	vol	NOUN
ecletica-1173	401	24	.	.	PROPN
ecletica-1173	401	25	46	46	NUM
ecletica-1173	401	26	,	,	PUNCT
ecletica-1173	401	27	n.	n.	NOUN
ecletica-1173	401	28	3	3	NUM
ecletica-1173	401	29	,	,	PUNCT
ecletica-1173	401	30	2021	2021	NUM
ecletica-1173	401	31	,	,	PUNCT
ecletica-1173	401	32	17	17	NUM
ecletica-1173	401	33	-	-	SYM
ecletica-1173	401	34	32	32	NUM
ecletica-1173	401	35	issn	issn	NOUN
ecletica-1173	401	36	:	:	PUNCT
ecletica-1173	401	37	1678	1678	NUM
ecletica-1173	401	38	-	-	SYM
ecletica-1173	401	39	4618	4618	NUM
ecletica-1173	401	40	doi	doi	NOUN
ecletica-1173	401	41	:	:	PUNCT
ecletica-1173	401	42	10.26850/1678	10.26850/1678	NUM
ecletica-1173	401	43	-	-	SYM
ecletica-1173	401	44	4618eqj.v46.3.2021.p17	4618eqj.v46.3.2021.p17	NOUN
ecletica-1173	401	45	-	-	PUNCT
ecletica-1173	401	46	32	32	NUM
ecletica-1173	401	47	combinations	combination	NOUN
ecletica-1173	401	48	for	for	ADP
ecletica-1173	401	49	cancer	cancer	NOUN
ecletica-1173	401	50	treatment	treatment	NOUN
ecletica-1173	401	51	.	.	PUNCT
ecletica-1173	402	1	in	in	ADP
ecletica-1173	402	2	this	this	DET
ecletica-1173	402	3	calculation	calculation	NOUN
ecletica-1173	402	4	the	the	DET
ecletica-1173	402	5	kinase	kinase	NOUN
ecletica-1173	402	6	inhibition	inhibition	NOUN
ecletica-1173	402	7	profile	profile	NOUN
ecletica-1173	402	8	and	and	CCONJ
ecletica-1173	402	9	the	the	DET
ecletica-1173	402	10	region	region	NOUN
ecletica-1173	402	11	with	with	ADP
ecletica-1173	402	12	tumor	tumor	NOUN
ecletica-1173	402	13	are	be	AUX
ecletica-1173	402	14	used	use	VERB
ecletica-1173	402	15	to	to	PART
ecletica-1173	402	16	develop	develop	VERB
ecletica-1173	402	17	a	a	DET
ecletica-1173	402	18	set	set	NOUN
ecletica-1173	402	19	of	of	ADP
ecletica-1173	402	20	drugs	drug	NOUN
ecletica-1173	402	21	as	as	ADV
ecletica-1173	402	22	well	well	ADV
ecletica-1173	402	23	as	as	ADP
ecletica-1173	402	24	to	to	PART
ecletica-1173	402	25	anticipate	anticipate	VERB
ecletica-1173	402	26	tumor	tumor	NOUN
ecletica-1173	402	27	sensitivities	sensitivity	NOUN
ecletica-1173	402	28	for	for	ADP
ecletica-1173	402	29	new	new	ADJ
ecletica-1173	402	30	drugs	drug	NOUN
ecletica-1173	402	31	or	or	CCONJ
ecletica-1173	402	32	drug	drug	NOUN
ecletica-1173	402	33	combinations	combination	NOUN
ecletica-1173	402	34	(	(	PUNCT
ecletica-1173	402	35	pal	pal	NOUN
ecletica-1173	402	36	and	and	CCONJ
ecletica-1173	402	37	berlow	berlow	NOUN
ecletica-1173	402	38	,	,	PUNCT
ecletica-1173	402	39	2012	2012	NUM
ecletica-1173	402	40	)	)	PUNCT
ecletica-1173	402	41	.	.	PUNCT
ecletica-1173	403	1	vital	vital	ADJ
ecletica-1173	403	2	kinases	kinase	NOUN
ecletica-1173	403	3	for	for	ADP
ecletica-1173	403	4	mesenchymal	mesenchymal	ADJ
ecletica-1173	403	5	and	and	CCONJ
ecletica-1173	403	6	epithelial	epithelial	ADJ
ecletica-1173	403	7	cell	cell	NOUN
ecletica-1173	403	8	migration	migration	NOUN
ecletica-1173	403	9	were	be	AUX
ecletica-1173	403	10	anticipated	anticipate	VERB
ecletica-1173	403	11	,	,	PUNCT
ecletica-1173	403	12	employing	employ	VERB
ecletica-1173	403	13	a	a	DET
ecletica-1173	403	14	joint	joint	ADJ
ecletica-1173	403	15	approach	approach	NOUN
ecletica-1173	403	16	to	to	ADP
ecletica-1173	403	17	strong	strong	ADJ
ecletica-1173	403	18	cancer	cancer	NOUN
ecletica-1173	403	19	drug	drug	NOUN
ecletica-1173	403	20	combinations	combination	NOUN
ecletica-1173	403	21	.	.	PUNCT
ecletica-1173	404	1	this	this	DET
ecletica-1173	404	2	pooled	pool	VERB
ecletica-1173	404	3	approach	approach	NOUN
ecletica-1173	404	4	uses	use	VERB
ecletica-1173	404	5	flexible	flexible	ADJ
ecletica-1173	404	6	net	net	ADJ
ecletica-1173	404	7	regularization	regularization	NOUN
ecletica-1173	404	8	with	with	ADP
ecletica-1173	404	9	mrna	mrna	PROPN
ecletica-1173	404	10	expression	expression	NOUN
ecletica-1173	404	11	profiling	profiling	NOUN
ecletica-1173	404	12	and	and	CCONJ
ecletica-1173	404	13	a	a	DET
ecletica-1173	404	14	huge	huge	ADJ
ecletica-1173	404	15	set	set	NOUN
ecletica-1173	404	16	of	of	ADP
ecletica-1173	404	17	kinase	kinase	NOUN
ecletica-1173	404	18	inhibition	inhibition	NOUN
ecletica-1173	404	19	.	.	PUNCT
ecletica-1173	405	1	9	9	X
ecletica-1173	405	2	.	.	X
ecletica-1173	405	3	concluding	conclude	VERB
ecletica-1173	405	4	remarks	remark	NOUN
ecletica-1173	405	5	today	today	NOUN
ecletica-1173	405	6	,	,	PUNCT
ecletica-1173	405	7	there	there	PRON
ecletica-1173	405	8	is	be	VERB
ecletica-1173	405	9	a	a	DET
ecletica-1173	405	10	clear	clear	ADJ
ecletica-1173	405	11	application	application	NOUN
ecletica-1173	405	12	of	of	ADP
ecletica-1173	405	13	methodological	methodological	ADJ
ecletica-1173	405	14	reductionism	reductionism	NOUN
ecletica-1173	405	15	to	to	PART
ecletica-1173	405	16	develop	develop	VERB
ecletica-1173	405	17	new	new	ADJ
ecletica-1173	405	18	drugs	drug	NOUN
ecletica-1173	405	19	although	although	SCONJ
ecletica-1173	405	20	there	there	PRON
ecletica-1173	405	21	is	be	VERB
ecletica-1173	405	22	a	a	DET
ecletica-1173	405	23	grasp	grasp	NOUN
ecletica-1173	405	24	that	that	SCONJ
ecletica-1173	405	25	holism	holism	NOUN
ecletica-1173	405	26	must	must	AUX
ecletica-1173	405	27	be	be	AUX
ecletica-1173	405	28	reached	reach	VERB
ecletica-1173	405	29	to	to	PART
ecletica-1173	405	30	understand	understand	VERB
ecletica-1173	405	31	the	the	DET
ecletica-1173	405	32	full	full	ADJ
ecletica-1173	405	33	biological	biological	ADJ
ecletica-1173	405	34	process	process	NOUN
ecletica-1173	405	35	.	.	PUNCT
ecletica-1173	406	1	on	on	ADP
ecletica-1173	406	2	the	the	DET
ecletica-1173	406	3	other	other	ADJ
ecletica-1173	406	4	hand	hand	NOUN
ecletica-1173	406	5	,	,	PUNCT
ecletica-1173	406	6	holistic	holistic	ADJ
ecletica-1173	406	7	approaches	approach	NOUN
ecletica-1173	406	8	like	like	ADP
ecletica-1173	406	9	system	system	NOUN
ecletica-1173	406	10	biology	biology	NOUN
ecletica-1173	406	11	use	use	VERB
ecletica-1173	406	12	some	some	DET
ecletica-1173	406	13	reductionist	reductionist	ADJ
ecletica-1173	406	14	methodologies	methodology	NOUN
ecletica-1173	406	15	to	to	PART
ecletica-1173	406	16	build	build	VERB
ecletica-1173	406	17	a	a	DET
ecletica-1173	406	18	whole	whole	ADJ
ecletica-1173	406	19	vision	vision	NOUN
ecletica-1173	406	20	of	of	ADP
ecletica-1173	406	21	the	the	DET
ecletica-1173	406	22	organism	organism	NOUN
ecletica-1173	406	23	.	.	PUNCT
ecletica-1173	407	1	nowadays	nowadays	ADV
ecletica-1173	407	2	,	,	PUNCT
ecletica-1173	407	3	a	a	DET
ecletica-1173	407	4	balancing	balancing	NOUN
ecletica-1173	407	5	of	of	ADP
ecletica-1173	407	6	methodological	methodological	ADJ
ecletica-1173	407	7	reductionist	reductionist	NOUN
ecletica-1173	407	8	approach	approach	NOUN
ecletica-1173	407	9	and	and	CCONJ
ecletica-1173	407	10	the	the	DET
ecletica-1173	407	11	holistic	holistic	ADJ
ecletica-1173	407	12	view	view	NOUN
ecletica-1173	407	13	is	be	AUX
ecletica-1173	407	14	combined	combine	VERB
ecletica-1173	407	15	to	to	PART
ecletica-1173	407	16	produce	produce	VERB
ecletica-1173	407	17	new	new	ADJ
ecletica-1173	407	18	drugs	drug	NOUN
ecletica-1173	407	19	and	and	CCONJ
ecletica-1173	407	20	understand	understand	VERB
ecletica-1173	407	21	new	new	ADJ
ecletica-1173	407	22	diseases	disease	NOUN
ecletica-1173	407	23	.	.	PUNCT
ecletica-1173	408	1	authors	author	NOUN
ecletica-1173	408	2	’	’	PART
ecletica-1173	408	3	contribution	contribution	NOUN
ecletica-1173	408	4	conceptualization	conceptualization	NOUN
ecletica-1173	408	5	:	:	PUNCT
ecletica-1173	408	6	augusto	augusto	NOUN
ecletica-1173	408	7	,	,	PUNCT
ecletica-1173	408	8	d.	d.	PROPN
ecletica-1173	408	9	a.	a.	PROPN
ecletica-1173	408	10	b.	b.	PROPN
ecletica-1173	408	11	data	data	PROPN
ecletica-1173	408	12	curation	curation	NOUN
ecletica-1173	408	13	:	:	PUNCT
ecletica-1173	408	14	not	not	PART
ecletica-1173	408	15	applicable	applicable	ADJ
ecletica-1173	408	16	.	.	PUNCT
ecletica-1173	409	1	formal	formal	ADJ
ecletica-1173	409	2	analysis	analysis	NOUN
ecletica-1173	409	3	:	:	PUNCT
ecletica-1173	409	4	not	not	PART
ecletica-1173	409	5	applicable	applicable	ADJ
ecletica-1173	409	6	.	.	PUNCT
ecletica-1173	410	1	funding	funding	NOUN
ecletica-1173	410	2	acquisition	acquisition	NOUN
ecletica-1173	410	3	:	:	PUNCT
ecletica-1173	410	4	not	not	PART
ecletica-1173	410	5	applicable	applicable	ADJ
ecletica-1173	410	6	.	.	PUNCT
ecletica-1173	411	1	investigation	investigation	NOUN
ecletica-1173	411	2	:	:	PUNCT
ecletica-1173	411	3	augusto	augusto	PROPN
ecletica-1173	411	4	,	,	PUNCT
ecletica-1173	411	5	d.	d.	PROPN
ecletica-1173	411	6	a.	a.	PROPN
ecletica-1173	411	7	b.	b.	PROPN
ecletica-1173	411	8	;	;	PUNCT
ecletica-1173	411	9	niculau	niculau	PROPN
ecletica-1173	411	10	,	,	PUNCT
ecletica-1173	411	11	e.	e.	PROPN
ecletica-1173	411	12	s.	s.	PROPN
ecletica-1173	411	13	methodology	methodology	PROPN
ecletica-1173	411	14	:	:	PUNCT
ecletica-1173	411	15	not	not	PART
ecletica-1173	411	16	applicable	applicable	ADJ
ecletica-1173	411	17	.	.	PUNCT
ecletica-1173	412	1	project	project	NOUN
ecletica-1173	412	2	administration	administration	NOUN
ecletica-1173	412	3	:	:	PUNCT
ecletica-1173	412	4	not	not	PART
ecletica-1173	412	5	applicable	applicable	ADJ
ecletica-1173	412	6	.	.	PUNCT
ecletica-1173	413	1	resources	resource	NOUN
ecletica-1173	413	2	:	:	PUNCT
ecletica-1173	413	3	not	not	PART
ecletica-1173	413	4	applicable	applicable	ADJ
ecletica-1173	413	5	.	.	PUNCT
ecletica-1173	414	1	software	software	NOUN
ecletica-1173	414	2	:	:	PUNCT
ecletica-1173	414	3	not	not	PART
ecletica-1173	414	4	applicable	applicable	ADJ
ecletica-1173	414	5	.	.	PUNCT
ecletica-1173	415	1	supervision	supervision	NOUN
ecletica-1173	415	2	:	:	PUNCT
ecletica-1173	415	3	not	not	PART
ecletica-1173	415	4	applicable	applicable	ADJ
ecletica-1173	415	5	.	.	PUNCT
ecletica-1173	416	1	validation	validation	NOUN
ecletica-1173	416	2	:	:	PUNCT
ecletica-1173	416	3	not	not	PART
ecletica-1173	416	4	applicable	applicable	ADJ
ecletica-1173	416	5	.	.	PUNCT
ecletica-1173	417	1	visualization	visualization	NOUN
ecletica-1173	417	2	:	:	PUNCT
ecletica-1173	417	3	not	not	PART
ecletica-1173	417	4	applicable	applicable	ADJ
ecletica-1173	417	5	.	.	PUNCT
ecletica-1173	418	1	writing	write	VERB
ecletica-1173	418	2	–	–	PUNCT
ecletica-1173	418	3	original	original	ADJ
ecletica-1173	418	4	draft	draft	NOUN
ecletica-1173	418	5	:	:	PUNCT
ecletica-1173	418	6	not	not	PART
ecletica-1173	418	7	applicable	applicable	ADJ
ecletica-1173	418	8	.	.	PUNCT
ecletica-1173	419	1	writing	write	VERB
ecletica-1173	419	2	–	–	PUNCT
ecletica-1173	419	3	review	review	NOUN
ecletica-1173	419	4	&	&	CCONJ
ecletica-1173	419	5	editing	editing	NOUN
ecletica-1173	419	6	:	:	PUNCT
ecletica-1173	419	7	augusto	augusto	NOUN
ecletica-1173	419	8	,	,	PUNCT
ecletica-1173	419	9	d.	d.	PROPN
ecletica-1173	419	10	a.	a.	PROPN
ecletica-1173	419	11	b.	b.	PROPN
ecletica-1173	419	12	;	;	PUNCT
ecletica-1173	419	13	niculau	niculau	PROPN
ecletica-1173	419	14	,	,	PUNCT
ecletica-1173	419	15	e.	e.	PROPN
ecletica-1173	419	16	s.	s.	PROPN
ecletica-1173	419	17	data	data	PROPN
ecletica-1173	419	18	availability	availability	PROPN
ecletica-1173	419	19	statement	statement	NOUN
ecletica-1173	419	20	data	datum	NOUN
ecletica-1173	419	21	sharing	sharing	NOUN
ecletica-1173	419	22	is	be	AUX
ecletica-1173	419	23	not	not	PART
ecletica-1173	419	24	applicable	applicable	ADJ
ecletica-1173	419	25	.	.	PUNCT
ecletica-1173	420	1	funding	fund	VERB
ecletica-1173	420	2	not	not	PART
ecletica-1173	420	3	applicable	applicable	ADJ
ecletica-1173	420	4	.	.	PUNCT
ecletica-1173	421	1	acknowledgments	acknowledgment	NOUN
ecletica-1173	421	2	not	not	PART
ecletica-1173	421	3	applicable	applicable	ADJ
ecletica-1173	421	4	.	.	PUNCT
ecletica-1173	422	1	references	reference	NOUN
ecletica-1173	422	2	abdelgalil	abdelgalil	PROPN
ecletica-1173	422	3	,	,	PUNCT
ecletica-1173	422	4	a.	a.	NOUN
ecletica-1173	422	5	a.	a.	PROPN
ecletica-1173	422	6	;	;	PUNCT
ecletica-1173	422	7	alam	alam	PROPN
ecletica-1173	422	8	,	,	PUNCT
ecletica-1173	422	9	m.	m.	NOUN
ecletica-1173	422	10	a.	a.	NOUN
ecletica-1173	422	11	;	;	PUNCT
ecletica-1173	422	12	raish	raish	NOUN
ecletica-1173	422	13	,	,	PUNCT
ecletica-1173	422	14	m.	m.	NOUN
ecletica-1173	422	15	;	;	PUNCT
ecletica-1173	422	16	mohammed	mohammed	PROPN
ecletica-1173	422	17	,	,	PUNCT
ecletica-1173	422	18	i.	i.	PROPN
ecletica-1173	422	19	e.	e.	PROPN
ecletica-1173	422	20	;	;	PUNCT
ecletica-1173	422	21	mohammed	mohammed	PROPN
ecletica-1173	422	22	,	,	PUNCT
ecletica-1173	422	23	a.-e	a.-e	PROPN
ecletica-1173	422	24	.	.	PUNCT
ecletica-1173	423	1	h.	h.	PROPN
ecletica-1173	423	2	;	;	PUNCT
ecletica-1173	423	3	ansari	ansari	PROPN
ecletica-1173	423	4	,	,	PUNCT
ecletica-1173	423	5	m.	m.	NOUN
ecletica-1173	423	6	a.	a.	PROPN
ecletica-1173	423	7	;	;	PUNCT
ecletica-1173	423	8	al	al	PROPN
ecletica-1173	423	9	jenoobi	jenoobi	PROPN
ecletica-1173	423	10	,	,	PUNCT
ecletica-1173	423	11	f.	f.	PROPN
ecletica-1173	423	12	i.	i.	PROPN
ecletica-1173	423	13	dasatinib	dasatinib	PROPN
ecletica-1173	423	14	significantly	significantly	ADV
ecletica-1173	423	15	reduced	reduce	VERB
ecletica-1173	423	16	in	in	ADP
ecletica-1173	423	17	vivo	vivo	ADJ
ecletica-1173	423	18	exposure	exposure	NOUN
ecletica-1173	423	19	to	to	ADP
ecletica-1173	423	20	cyclosporine	cyclosporine	VERB
ecletica-1173	423	21	in	in	ADP
ecletica-1173	423	22	a	a	DET
ecletica-1173	423	23	rat	rat	NOUN
ecletica-1173	423	24	model	model	NOUN
ecletica-1173	423	25	:	:	PUNCT
ecletica-1173	423	26	the	the	DET
ecletica-1173	423	27	possible	possible	ADJ
ecletica-1173	423	28	involvement	involvement	NOUN
ecletica-1173	423	29	of	of	ADP
ecletica-1173	423	30	cyp3a	cyp3a	NOUN
ecletica-1173	423	31	induction	induction	NOUN
ecletica-1173	423	32	.	.	PUNCT
ecletica-1173	424	1	pharmacol	pharmacol	PROPN
ecletica-1173	424	2	.	.	PUNCT
ecletica-1173	424	3	rep	rep	PROPN
ecletica-1173	424	4	.	.	PROPN
ecletica-1173	424	5	2019	2019	NUM
ecletica-1173	424	6	,	,	PUNCT
ecletica-1173	424	7	71	71	NUM
ecletica-1173	424	8	(	(	PUNCT
ecletica-1173	424	9	2	2	NUM
ecletica-1173	424	10	)	)	PUNCT
ecletica-1173	424	11	,	,	PUNCT
ecletica-1173	424	12	201–205	201–205	NUM
ecletica-1173	424	13	.	.	PUNCT
ecletica-1173	425	1	https://doi.org/10.1016/j.pharep.2018.10.018	https://doi.org/10.1016/j.pharep.2018.10.018	PROPN
ecletica-1173	425	2	.	.	PUNCT
ecletica-1173	426	1	ahn	ahn	PROPN
ecletica-1173	426	2	,	,	PUNCT
ecletica-1173	426	3	a.	a.	PROPN
ecletica-1173	426	4	c.	c.	PROPN
ecletica-1173	426	5	;	;	PUNCT
ecletica-1173	426	6	tewari	tewari	PROPN
ecletica-1173	426	7	,	,	PUNCT
ecletica-1173	426	8	m.	m.	NOUN
ecletica-1173	426	9	;	;	PUNCT
ecletica-1173	426	10	poon	poon	NOUN
ecletica-1173	426	11	,	,	PUNCT
ecletica-1173	426	12	c.-s	c.-	NOUN
ecletica-1173	426	13	.	.	PUNCT
ecletica-1173	426	14	;	;	PUNCT
ecletica-1173	426	15	phillips	phillips	PROPN
ecletica-1173	426	16	,	,	PUNCT
ecletica-1173	426	17	r.	r.	PROPN
ecletica-1173	426	18	s.	s.	PROPN
ecletica-1173	427	1	the	the	DET
ecletica-1173	427	2	limits	limit	NOUN
ecletica-1173	427	3	of	of	ADP
ecletica-1173	427	4	reductionism	reductionism	NOUN
ecletica-1173	427	5	in	in	ADP
ecletica-1173	427	6	medicine	medicine	NOUN
ecletica-1173	427	7	:	:	PUNCT
ecletica-1173	427	8	could	could	AUX
ecletica-1173	427	9	systems	system	NOUN
ecletica-1173	427	10	biology	biology	NOUN
ecletica-1173	427	11	offer	offer	VERB
ecletica-1173	427	12	an	an	DET
ecletica-1173	427	13	alternative	alternative	NOUN
ecletica-1173	427	14	?	?	PUNCT
ecletica-1173	428	1	plos	plos	PROPN
ecletica-1173	428	2	med	med	PROPN
ecletica-1173	428	3	.	.	PUNCT
ecletica-1173	429	1	2006	2006	NUM
ecletica-1173	429	2	,	,	PUNCT
ecletica-1173	429	3	3	3	NUM
ecletica-1173	429	4	(	(	PUNCT
ecletica-1173	429	5	6	6	NUM
ecletica-1173	429	6	)	)	PUNCT
ecletica-1173	429	7	,	,	PUNCT
ecletica-1173	429	8	e208	e208	PROPN
ecletica-1173	429	9	.	.	PUNCT
ecletica-1173	430	1	https://doi.org/10.1371/journal.pmed.0030208	https://doi.org/10.1371/journal.pmed.0030208	PROPN
ecletica-1173	430	2	.	.	PUNCT
ecletica-1173	430	3	akhtar	akhtar	PROPN
ecletica-1173	430	4	,	,	PUNCT
ecletica-1173	430	5	n.	n.	NOUN
ecletica-1173	430	6	;	;	PUNCT
ecletica-1173	430	7	jabeen	jabeen	PROPN
ecletica-1173	430	8	,	,	PUNCT
ecletica-1173	430	9	i.	i.	PROPN
ecletica-1173	430	10	;	;	PUNCT
ecletica-1173	430	11	jalal	jalal	PROPN
ecletica-1173	430	12	,	,	PUNCT
ecletica-1173	430	13	n.	n.	PROPN
ecletica-1173	430	14	;	;	PUNCT
ecletica-1173	430	15	antilla	antilla	PROPN
ecletica-1173	430	16	,	,	PUNCT
ecletica-1173	430	17	j.	j.	PROPN
ecletica-1173	430	18	structure	structure	NOUN
ecletica-1173	430	19	-	-	PUNCT
ecletica-1173	430	20	based	base	VERB
ecletica-1173	430	21	pharmacophore	pharmacophore	NOUN
ecletica-1173	430	22	models	model	NOUN
ecletica-1173	430	23	to	to	PART
ecletica-1173	430	24	probe	probe	VERB
ecletica-1173	430	25	anticancer	anticancer	NOUN
ecletica-1173	430	26	activity	activity	NOUN
ecletica-1173	430	27	of	of	ADP
ecletica-1173	430	28	inhibitors	inhibitor	NOUN
ecletica-1173	430	29	of	of	ADP
ecletica-1173	430	30	protein	protein	NOUN
ecletica-1173	430	31	kinase	kinase	NOUN
ecletica-1173	430	32	b	b	X
ecletica-1173	430	33	-	-	PUNCT
ecletica-1173	430	34	beta	beta	NOUN
ecletica-1173	430	35	(	(	PUNCT
ecletica-1173	430	36	pkb	pkb	PROPN
ecletica-1173	430	37	β	β	PROPN
ecletica-1173	430	38	)	)	PUNCT
ecletica-1173	430	39	.	.	PUNCT
ecletica-1173	431	1	chem	chem	NOUN
ecletica-1173	431	2	.	.	PUNCT
ecletica-1173	432	1	biol	biol	PROPN
ecletica-1173	432	2	.	.	PUNCT
ecletica-1173	433	1	drug	drug	NOUN
ecletica-1173	433	2	.	.	PUNCT
ecletica-1173	434	1	des	des	PROPN
ecletica-1173	434	2	.	.	PROPN
ecletica-1173	434	3	2019	2019	NUM
ecletica-1173	434	4	,	,	PUNCT
ecletica-1173	434	5	93	93	NUM
ecletica-1173	434	6	(	(	PUNCT
ecletica-1173	434	7	3	3	NUM
ecletica-1173	434	8	)	)	PUNCT
ecletica-1173	434	9	,	,	PUNCT
ecletica-1173	434	10	325–336	325–336	NUM
ecletica-1173	434	11	.	.	PUNCT
ecletica-1173	435	1	https://doi.org/10.1111/cbdd.13418	https://doi.org/10.1111/cbdd.13418	NOUN
ecletica-1173	435	2	.	.	PUNCT
ecletica-1173	436	1	albergante	albergante	PROPN
ecletica-1173	436	2	,	,	PUNCT
ecletica-1173	436	3	l.	l.	PROPN
ecletica-1173	436	4	;	;	PUNCT
ecletica-1173	436	5	liu	liu	PROPN
ecletica-1173	436	6	,	,	PUNCT
ecletica-1173	436	7	d.	d.	PROPN
ecletica-1173	436	8	;	;	PUNCT
ecletica-1173	436	9	palmer	palmer	PROPN
ecletica-1173	436	10	,	,	PUNCT
ecletica-1173	436	11	s.	s.	PROPN
ecletica-1173	436	12	;	;	PUNCT
ecletica-1173	436	13	newman	newman	PROPN
ecletica-1173	436	14	,	,	PUNCT
ecletica-1173	436	15	t.	t.	PROPN
ecletica-1173	436	16	j.	j.	PROPN
ecletica-1173	436	17	insights	insight	NOUN
ecletica-1173	436	18	into	into	ADP
ecletica-1173	436	19	biological	biological	ADJ
ecletica-1173	436	20	complexity	complexity	NOUN
ecletica-1173	436	21	from	from	ADP
ecletica-1173	436	22	simple	simple	ADJ
ecletica-1173	436	23	foundations	foundation	NOUN
ecletica-1173	436	24	.	.	PUNCT
ecletica-1173	437	1	in	in	ADP
ecletica-1173	437	2	biophysics	biophysic	NOUN
ecletica-1173	437	3	of	of	ADP
ecletica-1173	437	4	infection	infection	NOUN
ecletica-1173	437	5	:	:	PUNCT
ecletica-1173	437	6	advances	advance	NOUN
ecletica-1173	437	7	in	in	ADP
ecletica-1173	437	8	experimental	experimental	ADJ
ecletica-1173	437	9	medicine	medicine	NOUN
ecletica-1173	437	10	and	and	CCONJ
ecletica-1173	437	11	biology	biology	NOUN
ecletica-1173	437	12	;	;	PUNCT
ecletica-1173	437	13	springer	springer	NOUN
ecletica-1173	437	14	,	,	PUNCT
ecletica-1173	437	15	2016	2016	NUM
ecletica-1173	437	16	;	;	PUNCT
ecletica-1173	437	17	pp	pp	ADP
ecletica-1173	438	1	295–305	295–305	NUM
ecletica-1173	438	2	.	.	PUNCT
ecletica-1173	439	1	https://doi.org/10.1007/978-3-319-32189-9_18	https://doi.org/10.1007/978-3-319-32189-9_18	PROPN
ecletica-1173	439	2	.	.	PROPN
ecletica-1173	439	3	alm	alm	PROPN
ecletica-1173	439	4	,	,	PUNCT
ecletica-1173	439	5	e.	e.	PROPN
ecletica-1173	439	6	;	;	PUNCT
ecletica-1173	439	7	arkin	arkin	PROPN
ecletica-1173	439	8	,	,	PUNCT
ecletica-1173	439	9	a.	a.	NOUN
ecletica-1173	439	10	p.	p.	NOUN
ecletica-1173	439	11	biological	biological	ADJ
ecletica-1173	439	12	networks	network	NOUN
ecletica-1173	439	13	.	.	PUNCT
ecletica-1173	440	1	curr	curr	PROPN
ecletica-1173	440	2	.	.	PUNCT
ecletica-1173	441	1	opin	opin	NOUN
ecletica-1173	441	2	.	.	PUNCT
ecletica-1173	441	3	struct	struct	NOUN
ecletica-1173	441	4	.	.	PUNCT
ecletica-1173	442	1	biol	biol	PROPN
ecletica-1173	442	2	.	.	PUNCT
ecletica-1173	443	1	2003	2003	NUM
ecletica-1173	443	2	,	,	PUNCT
ecletica-1173	443	3	13	13	NUM
ecletica-1173	443	4	(	(	PUNCT
ecletica-1173	443	5	2	2	NUM
ecletica-1173	443	6	)	)	PUNCT
ecletica-1173	443	7	,	,	PUNCT
ecletica-1173	443	8	193–202	193–202	NUM
ecletica-1173	443	9	.	.	PUNCT
ecletica-1173	444	1	https://doi.org/10.1016/s0959-440x(03)00031-9	https://doi.org/10.1016/s0959-440x(03)00031-9	NOUN
ecletica-1173	444	2	.	.	PUNCT
ecletica-1173	445	1	aucar	aucar	PROPN
ecletica-1173	445	2	,	,	PUNCT
ecletica-1173	445	3	m.	m.	NOUN
ecletica-1173	445	4	g.	g.	PROPN
ecletica-1173	445	5	;	;	PUNCT
ecletica-1173	445	6	cavasotto	cavasotto	NOUN
ecletica-1173	445	7	,	,	PUNCT
ecletica-1173	445	8	c.	c.	PROPN
ecletica-1173	445	9	n.	n.	PROPN
ecletica-1173	445	10	molecular	molecular	ADJ
ecletica-1173	445	11	docking	docking	NOUN
ecletica-1173	445	12	using	use	VERB
ecletica-1173	445	13	quantum	quantum	ADJ
ecletica-1173	445	14	mechanical	mechanical	ADJ
ecletica-1173	445	15	-	-	PUNCT
ecletica-1173	445	16	based	base	VERB
ecletica-1173	445	17	methods	method	NOUN
ecletica-1173	445	18	.	.	PUNCT
ecletica-1173	446	1	in	in	ADP
ecletica-1173	446	2	quantum	quantum	ADJ
ecletica-1173	446	3	mechanics	mechanic	NOUN
ecletica-1173	446	4	in	in	ADP
ecletica-1173	446	5	drug	drug	NOUN
ecletica-1173	446	6	discovery	discovery	NOUN
ecletica-1173	446	7	;	;	PUNCT
ecletica-1173	446	8	humana	humana	PROPN
ecletica-1173	446	9	,	,	PUNCT
ecletica-1173	446	10	2020	2020	NUM
ecletica-1173	446	11	.	.	PUNCT
ecletica-1173	447	1	https://doi.org/10.1007/978-1-0716-0282-9_17	https://doi.org/10.1007/978-1-0716-0282-9_17	PROPN
ecletica-1173	447	2	.	.	PUNCT
ecletica-1173	448	1	berg	berg	PROPN
ecletica-1173	448	2	,	,	PUNCT
ecletica-1173	448	3	e.	e.	PROPN
ecletica-1173	448	4	l.	l.	PROPN
ecletica-1173	448	5	systems	systems	PROPN
ecletica-1173	448	6	biology	biology	NOUN
ecletica-1173	448	7	in	in	ADP
ecletica-1173	448	8	drug	drug	NOUN
ecletica-1173	448	9	discovery	discovery	NOUN
ecletica-1173	448	10	and	and	CCONJ
ecletica-1173	448	11	development	development	NOUN
ecletica-1173	448	12	.	.	PUNCT
ecletica-1173	449	1	drug	drug	NOUN
ecletica-1173	449	2	discov	discov	NOUN
ecletica-1173	449	3	.	.	PUNCT
ecletica-1173	450	1	today	today	NOUN
ecletica-1173	450	2	2014	2014	NUM
ecletica-1173	450	3	,	,	PUNCT
ecletica-1173	450	4	19	19	NUM
ecletica-1173	450	5	(	(	PUNCT
ecletica-1173	450	6	2	2	NUM
ecletica-1173	450	7	)	)	PUNCT
ecletica-1173	450	8	,	,	PUNCT
ecletica-1173	450	9	113–125	113–125	NUM
ecletica-1173	450	10	.	.	PUNCT
ecletica-1173	451	1	https://doi.org/10.1016/j.drudis.2013.10.003	https://doi.org/10.1016/j.drudis.2013.10.003	PROPN
ecletica-1173	451	2	.	.	PUNCT
ecletica-1173	452	1	bieber	bieber	PROPN
ecletica-1173	452	2	,	,	PUNCT
ecletica-1173	452	3	t.	t.	NOUN
ecletica-1173	452	4	concept	concept	NOUN
ecletica-1173	452	5	and	and	CCONJ
ecletica-1173	452	6	scientific	scientific	ADJ
ecletica-1173	452	7	background	background	NOUN
ecletica-1173	452	8	of	of	ADP
ecletica-1173	452	9	personalized	personalized	ADJ
ecletica-1173	452	10	medicine	medicine	NOUN
ecletica-1173	452	11	.	.	PUNCT
ecletica-1173	453	1	in	in	ADP
ecletica-1173	453	2	personalized	personalized	ADJ
ecletica-1173	453	3	treatment	treatment	NOUN
ecletica-1173	453	4	options	option	NOUN
ecletica-1173	453	5	in	in	ADP
ecletica-1173	453	6	dermatology	dermatology	NOUN
ecletica-1173	453	7	;	;	PUNCT
ecletica-1173	453	8	springer	springer	NOUN
ecletica-1173	453	9	,	,	PUNCT
ecletica-1173	453	10	2015	2015	NUM
ecletica-1173	453	11	;	;	PUNCT
ecletica-1173	453	12	pp	pp	PROPN
ecletica-1173	453	13	1–5	1–5	PROPN
ecletica-1173	453	14	.	.	PUNCT
ecletica-1173	453	15	https://doi.org/10.1007/978-3-662-45840-2_1	https://doi.org/10.1007/978-3-662-45840-2_1	PROPN
ecletica-1173	453	16	.	.	PUNCT
ecletica-1173	453	17	birkbak	birkbak	PROPN
ecletica-1173	453	18	,	,	PUNCT
ecletica-1173	453	19	n.	n.	PROPN
ecletica-1173	453	20	j.	j.	PROPN
ecletica-1173	453	21	;	;	PUNCT
ecletica-1173	453	22	mcgranahan	mcgranahan	PROPN
ecletica-1173	453	23	,	,	PUNCT
ecletica-1173	453	24	n.	n.	NOUN
ecletica-1173	453	25	cancer	cancer	NOUN
ecletica-1173	453	26	genome	genome	NOUN
ecletica-1173	453	27	evolutionary	evolutionary	ADJ
ecletica-1173	453	28	trajectories	trajectory	NOUN
ecletica-1173	453	29	in	in	ADP
ecletica-1173	453	30	metastasis	metastasis	NOUN
ecletica-1173	453	31	.	.	PUNCT
ecletica-1173	454	1	cancer	cancer	NOUN
ecletica-1173	454	2	cell	cell	NOUN
ecletica-1173	454	3	2020	2020	NUM
ecletica-1173	454	4	,	,	PUNCT
ecletica-1173	454	5	37	37	NUM
ecletica-1173	454	6	(	(	PUNCT
ecletica-1173	454	7	1	1	NUM
ecletica-1173	454	8	)	)	PUNCT
ecletica-1173	454	9	,	,	PUNCT
ecletica-1173	454	10	8–19	8–19	NOUN
ecletica-1173	454	11	.	.	PUNCT
ecletica-1173	455	1	https://doi.org/10.1016/j.ccell.2019.12.004	https://doi.org/10.1016/j.ccell.2019.12.004	PROPN
ecletica-1173	455	2	.	.	PUNCT
ecletica-1173	456	1	blumberg	blumberg	PROPN
ecletica-1173	456	2	,	,	PUNCT
ecletica-1173	456	3	j.	j.	PROPN
ecletica-1173	456	4	the	the	DET
ecletica-1173	456	5	alpha	alpha	NOUN
ecletica-1173	456	6	-	-	PUNCT
ecletica-1173	456	7	tocopherol	tocopherol	NOUN
ecletica-1173	456	8	,	,	PUNCT
ecletica-1173	456	9	beta	beta	NOUN
ecletica-1173	456	10	-	-	PUNCT
ecletica-1173	456	11	carotene	carotene	NOUN
ecletica-1173	456	12	cancer	cancer	NOUN
ecletica-1173	456	13	prevention	prevention	NOUN
ecletica-1173	456	14	study	study	NOUN
ecletica-1173	456	15	in	in	ADP
ecletica-1173	456	16	finland	finland	PROPN
ecletica-1173	456	17	.	.	PUNCT
ecletica-1173	457	1	nutr	nutr	PROPN
ecletica-1173	457	2	.	.	PROPN
ecletica-1173	457	3	rev	rev	PROPN
ecletica-1173	457	4	.	.	PROPN
ecletica-1173	457	5	1994	1994	NUM
ecletica-1173	457	6	,	,	PUNCT
ecletica-1173	457	7	52	52	NUM
ecletica-1173	457	8	(	(	PUNCT
ecletica-1173	457	9	7	7	NUM
ecletica-1173	457	10	)	)	PUNCT
ecletica-1173	457	11	,	,	PUNCT
ecletica-1173	457	12	242	242	NUM
ecletica-1173	457	13	–	–	PUNCT
ecletica-1173	457	14	245	245	NUM
ecletica-1173	457	15	.	.	PUNCT
ecletica-1173	458	1	https://doi.org/10.1111/j.1753-4887.1994.tb01430.x	https://doi.org/10.1111/j.1753-4887.1994.tb01430.x	PROPN
ecletica-1173	458	2	.	.	PUNCT
ecletica-1173	459	1	http://revista.iq.unesp.br/ojs/index.php/ecletica/index	http://revista.iq.unesp.br/ojs/index.php/ecletica/index	NOUN
ecletica-1173	459	2	https://doi.org/10.26850/1678-4618eqj.v46.3.2021.p17-32	https://doi.org/10.26850/1678-4618eqj.v46.3.2021.p17-32	PROPN
ecletica-1173	459	3	https://doi.org/10.1016/j.pharep.2018.10.018	https://doi.org/10.1016/j.pharep.2018.10.018	PROPN
ecletica-1173	459	4	https://doi.org/10.1016/j.pharep.2018.10.018	https://doi.org/10.1016/j.pharep.2018.10.018	PROPN
ecletica-1173	459	5	https://doi.org/10.1016/j.pharep.2018.10.018	https://doi.org/10.1016/j.pharep.2018.10.018	PROPN
ecletica-1173	459	6	https://doi.org/10.1016/j.pharep.2018.10.018	https://doi.org/10.1016/j.pharep.2018.10.018	PROPN
ecletica-1173	459	7	https://doi.org/10.1016/j.pharep.2018.10.018	https://doi.org/10.1016/j.pharep.2018.10.018	PROPN
ecletica-1173	459	8	https://doi.org/10.1016/j.pharep.2018.10.018	https://doi.org/10.1016/j.pharep.2018.10.018	PROPN
ecletica-1173	459	9	https://doi.org/10.1371/journal.pmed.0030208	https://doi.org/10.1371/journal.pmed.0030208	PROPN
ecletica-1173	459	10	https://doi.org/10.1371/journal.pmed.0030208	https://doi.org/10.1371/journal.pmed.0030208	PROPN
ecletica-1173	459	11	https://doi.org/10.1371/journal.pmed.0030208	https://doi.org/10.1371/journal.pmed.0030208	PROPN
ecletica-1173	459	12	https://doi.org/10.1371/journal.pmed.0030208	https://doi.org/10.1371/journal.pmed.0030208	PROPN
ecletica-1173	459	13	https://doi.org/10.1111/cbdd.13418	https://doi.org/10.1111/cbdd.13418	NOUN
ecletica-1173	459	14	https://doi.org/10.1111/cbdd.13418	https://doi.org/10.1111/cbdd.13418	NOUN
ecletica-1173	459	15	https://doi.org/10.1111/cbdd.13418	https://doi.org/10.1111/cbdd.13418	NOUN
ecletica-1173	459	16	https://doi.org/10.1111/cbdd.13418	https://doi.org/10.1111/cbdd.13418	NOUN
ecletica-1173	459	17	https://doi.org/10.1111/cbdd.13418	https://doi.org/10.1111/cbdd.13418	NOUN
ecletica-1173	460	1	https://doi.org/10.1007/978-3-319-32189-9_18	https://doi.org/10.1007/978-3-319-32189-9_18	PROPN
ecletica-1173	461	1	https://doi.org/10.1007/978-3-319-32189-9_18	https://doi.org/10.1007/978-3-319-32189-9_18	PROPN
ecletica-1173	462	1	https://doi.org/10.1007/978-3-319-32189-9_18	https://doi.org/10.1007/978-3-319-32189-9_18	PROPN
ecletica-1173	463	1	https://doi.org/10.1007/978-3-319-32189-9_18	https://doi.org/10.1007/978-3-319-32189-9_18	PROPN
ecletica-1173	464	1	https://doi.org/10.1007/978-3-319-32189-9_18	https://doi.org/10.1007/978-3-319-32189-9_18	PROPN
ecletica-1173	464	2	https://doi.org/10.1016/s0959-440x(03)00031-9	https://doi.org/10.1016/s0959-440x(03)00031-9	VERB
ecletica-1173	464	3	https://doi.org/10.1016/s0959-440x(03)00031-9	https://doi.org/10.1016/s0959-440x(03)00031-9	AUX
ecletica-1173	464	4	https://doi.org/10.1016/s0959-440x(03)00031-9	https://doi.org/10.1016/s0959-440x(03)00031-9	NOUN
ecletica-1173	464	5	https://doi.org/10.1007/978-1-0716-0282-9_17	https://doi.org/10.1007/978-1-0716-0282-9_17	NOUN
ecletica-1173	464	6	https://doi.org/10.1007/978-1-0716-0282-9_17	https://doi.org/10.1007/978-1-0716-0282-9_17	NOUN
ecletica-1173	464	7	https://doi.org/10.1007/978-1-0716-0282-9_17	https://doi.org/10.1007/978-1-0716-0282-9_17	NOUN
ecletica-1173	464	8	https://doi.org/10.1007/978-1-0716-0282-9_17	https://doi.org/10.1007/978-1-0716-0282-9_17	VERB
ecletica-1173	464	9	https://doi.org/10.1016/j.drudis.2013.10.003	https://doi.org/10.1016/j.drudis.2013.10.003	PROPN
ecletica-1173	464	10	https://doi.org/10.1016/j.drudis.2013.10.003	https://doi.org/10.1016/j.drudis.2013.10.003	PROPN
ecletica-1173	464	11	https://doi.org/10.1016/j.drudis.2013.10.003	https://doi.org/10.1016/j.drudis.2013.10.003	PROPN
ecletica-1173	464	12	https://doi.org/10.1007/978-3-662-45840-2_1	https://doi.org/10.1007/978-3-662-45840-2_1	PROPN
ecletica-1173	464	13	https://doi.org/10.1007/978-3-662-45840-2_1	https://doi.org/10.1007/978-3-662-45840-2_1	PROPN
ecletica-1173	464	14	https://doi.org/10.1007/978-3-662-45840-2_1	https://doi.org/10.1007/978-3-662-45840-2_1	PROPN
ecletica-1173	464	15	https://doi.org/10.1007/978-3-662-45840-2_1	https://doi.org/10.1007/978-3-662-45840-2_1	PROPN
ecletica-1173	464	16	https://doi.org/10.1016/j.ccell.2019.12.004	https://doi.org/10.1016/j.ccell.2019.12.004	PROPN
ecletica-1173	464	17	https://doi.org/10.1016/j.ccell.2019.12.004	https://doi.org/10.1016/j.ccell.2019.12.004	PROPN
ecletica-1173	464	18	https://doi.org/10.1016/j.ccell.2019.12.004	https://doi.org/10.1016/j.ccell.2019.12.004	PROPN
ecletica-1173	464	19	https://doi.org/10.1111/j.1753-4887.1994.tb01430.x	https://doi.org/10.1111/j.1753-4887.1994.tb01430.x	PROPN
ecletica-1173	464	20	https://doi.org/10.1111/j.1753-4887.1994.tb01430.x	https://doi.org/10.1111/j.1753-4887.1994.tb01430.x	PROPN
ecletica-1173	464	21	https://doi.org/10.1111/j.1753-4887.1994.tb01430.x	https://doi.org/10.1111/j.1753-4887.1994.tb01430.x	PROPN
ecletica-1173	464	22	review	review	NOUN
ecletica-1173	464	23	article	article	NOUN
ecletica-1173	464	24	iq.unesp.br/ecletica	iq.unesp.br/ecletica	PROPN
ecletica-1173	464	25	29	29	NUM
ecletica-1173	464	26	eclética	eclética	PROPN
ecletica-1173	464	27	química	química	PROPN
ecletica-1173	464	28	journal	journal	PROPN
ecletica-1173	464	29	,	,	PUNCT
ecletica-1173	464	30	vol	vol	NOUN
ecletica-1173	464	31	.	.	PROPN
ecletica-1173	464	32	46	46	NUM
ecletica-1173	464	33	,	,	PUNCT
ecletica-1173	464	34	n.	n.	NOUN
ecletica-1173	464	35	3	3	NUM
ecletica-1173	464	36	,	,	PUNCT
ecletica-1173	464	37	2021	2021	NUM
ecletica-1173	464	38	,	,	PUNCT
ecletica-1173	464	39	17	17	NUM
ecletica-1173	464	40	-	-	SYM
ecletica-1173	464	41	32	32	NUM
ecletica-1173	464	42	issn	issn	NOUN
ecletica-1173	464	43	:	:	PUNCT
ecletica-1173	464	44	1678	1678	NUM
ecletica-1173	464	45	-	-	SYM
ecletica-1173	464	46	4618	4618	NUM
ecletica-1173	464	47	doi	doi	NOUN
ecletica-1173	464	48	:	:	PUNCT
ecletica-1173	464	49	10.26850/1678	10.26850/1678	NUM
ecletica-1173	464	50	-	-	SYM
ecletica-1173	464	51	4618eqj.v46.3.2021.p17	4618eqj.v46.3.2021.p17	NOUN
ecletica-1173	464	52	-	-	PUNCT
ecletica-1173	464	53	32	32	NUM
ecletica-1173	464	54	born	bear	VERB
ecletica-1173	464	55	,	,	PUNCT
ecletica-1173	464	56	m.	m.	NOUN
ecletica-1173	464	57	;	;	PUNCT
ecletica-1173	464	58	oppenheimer	oppenheimer	PROPN
ecletica-1173	464	59	,	,	PUNCT
ecletica-1173	464	60	r.	r.	PROPN
ecletica-1173	464	61	zur	zur	PROPN
ecletica-1173	464	62	quantentheorie	quantentheorie	PROPN
ecletica-1173	464	63	der	der	NOUN
ecletica-1173	464	64	molekeln	molekeln	VERB
ecletica-1173	464	65	.	.	PUNCT
ecletica-1173	465	1	ann	ann	PROPN
ecletica-1173	465	2	.	.	PUNCT
ecletica-1173	466	1	phys	phys	PROPN
ecletica-1173	466	2	.	.	PUNCT
ecletica-1173	467	1	(	(	PUNCT
ecletica-1173	467	2	berl	berl	PROPN
ecletica-1173	467	3	.	.	PUNCT
ecletica-1173	467	4	)	)	PUNCT
ecletica-1173	468	1	1927	1927	NUM
ecletica-1173	468	2	,	,	PUNCT
ecletica-1173	468	3	389	389	NUM
ecletica-1173	468	4	(	(	PUNCT
ecletica-1173	468	5	20	20	NUM
ecletica-1173	468	6	)	)	PUNCT
ecletica-1173	468	7	,	,	PUNCT
ecletica-1173	468	8	457–484	457–484	NUM
ecletica-1173	468	9	.	.	PUNCT
ecletica-1173	469	1	https://doi.org/10.1002/andp.19273892002	https://doi.org/10.1002/andp.19273892002	NOUN
ecletica-1173	469	2	.	.	PUNCT
ecletica-1173	470	1	bosshard	bosshard	PROPN
ecletica-1173	470	2	,	,	PUNCT
ecletica-1173	470	3	h.	h.	PROPN
ecletica-1173	470	4	r.	r.	PROPN
ecletica-1173	470	5	molecular	molecular	PROPN
ecletica-1173	470	6	recognition	recognition	NOUN
ecletica-1173	470	7	by	by	ADP
ecletica-1173	470	8	induced	induced	ADJ
ecletica-1173	470	9	fit	fit	NOUN
ecletica-1173	470	10	:	:	PUNCT
ecletica-1173	470	11	how	how	SCONJ
ecletica-1173	470	12	fit	fit	ADJ
ecletica-1173	470	13	is	be	AUX
ecletica-1173	470	14	the	the	DET
ecletica-1173	470	15	concept	concept	NOUN
ecletica-1173	470	16	?	?	PUNCT
ecletica-1173	471	1	news	news	NOUN
ecletica-1173	471	2	physiol	physiol	PROPN
ecletica-1173	471	3	.	.	PUNCT
ecletica-1173	472	1	sci	sci	PROPN
ecletica-1173	472	2	.	.	PROPN
ecletica-1173	472	3	2001	2001	NUM
ecletica-1173	472	4	,	,	PUNCT
ecletica-1173	472	5	16	16	NUM
ecletica-1173	472	6	,	,	PUNCT
ecletica-1173	472	7	171–173	171–173	NUM
ecletica-1173	472	8	.	.	PUNCT
ecletica-1173	473	1	https://doi.org/10.1152/physiologyonline.2001.16.4.171	https://doi.org/10.1152/physiologyonline.2001.16.4.171	PROPN
ecletica-1173	473	2	.	.	PUNCT
ecletica-1173	474	1	boveri	boveri	PROPN
ecletica-1173	474	2	,	,	PUNCT
ecletica-1173	474	3	t.	t.	NOUN
ecletica-1173	474	4	the	the	DET
ecletica-1173	474	5	origin	origin	NOUN
ecletica-1173	474	6	of	of	ADP
ecletica-1173	474	7	malignant	malignant	ADJ
ecletica-1173	474	8	tumors	tumor	NOUN
ecletica-1173	474	9	;	;	PUNCT
ecletica-1173	474	10	baillière	baillière	NOUN
ecletica-1173	474	11	,	,	PUNCT
ecletica-1173	474	12	tindall	tindall	PROPN
ecletica-1173	474	13	&	&	CCONJ
ecletica-1173	474	14	cox	cox	PROPN
ecletica-1173	474	15	,	,	PUNCT
ecletica-1173	474	16	1929	1929	NUM
ecletica-1173	474	17	.	.	PUNCT
ecletica-1173	475	1	brown	brown	PROPN
ecletica-1173	475	2	,	,	PUNCT
ecletica-1173	475	3	n.	n.	PROPN
ecletica-1173	475	4	bioisosterism	bioisosterism	NOUN
ecletica-1173	475	5	in	in	ADP
ecletica-1173	475	6	medicinal	medicinal	ADJ
ecletica-1173	475	7	chemistry	chemistry	NOUN
ecletica-1173	475	8	.	.	PUNCT
ecletica-1173	476	1	in	in	ADP
ecletica-1173	476	2	bioisosteres	bioisostere	NOUN
ecletica-1173	476	3	in	in	ADP
ecletica-1173	476	4	medicinal	medicinal	ADJ
ecletica-1173	476	5	chemistry	chemistry	NOUN
ecletica-1173	476	6	;	;	PUNCT
ecletica-1173	476	7	wiley	wiley	PROPN
ecletica-1173	476	8	-	-	PUNCT
ecletica-1173	476	9	vch	vch	PROPN
ecletica-1173	476	10	,	,	PUNCT
ecletica-1173	476	11	2012	2012	NUM
ecletica-1173	476	12	;	;	PUNCT
ecletica-1173	476	13	pp	pp	PROPN
ecletica-1173	476	14	1–14	1–14	PROPN
ecletica-1173	476	15	.	.	PUNCT
ecletica-1173	477	1	https://doi.org/10.1002/9783527654307.ch1	https://doi.org/10.1002/9783527654307.ch1	PROPN
ecletica-1173	477	2	.	.	PUNCT
ecletica-1173	477	3	burton	burton	PROPN
ecletica-1173	477	4	,	,	PUNCT
ecletica-1173	477	5	d.	d.	PROPN
ecletica-1173	477	6	r.	r.	PROPN
ecletica-1173	477	7	;	;	PUNCT
ecletica-1173	477	8	desrosiers	desrosier	NOUN
ecletica-1173	477	9	,	,	PUNCT
ecletica-1173	477	10	r.	r.	PROPN
ecletica-1173	477	11	c.	c.	PROPN
ecletica-1173	477	12	;	;	PUNCT
ecletica-1173	477	13	doms	dom	NOUN
ecletica-1173	477	14	,	,	PUNCT
ecletica-1173	477	15	r.	r.	PROPN
ecletica-1173	477	16	w.	w.	PROPN
ecletica-1173	477	17	;	;	PUNCT
ecletica-1173	477	18	koff	koff	PROPN
ecletica-1173	477	19	,	,	PUNCT
ecletica-1173	477	20	w.	w.	PROPN
ecletica-1173	477	21	c.	c.	PROPN
ecletica-1173	477	22	;	;	PUNCT
ecletica-1173	477	23	kwong	kwong	PROPN
ecletica-1173	477	24	,	,	PUNCT
ecletica-1173	477	25	p.	p.	PROPN
ecletica-1173	477	26	d.	d.	PROPN
ecletica-1173	477	27	;	;	PUNCT
ecletica-1173	477	28	moore	moore	PROPN
ecletica-1173	477	29	,	,	PUNCT
ecletica-1173	477	30	j.	j.	PROPN
ecletica-1173	477	31	p.	p.	PROPN
ecletica-1173	477	32	;	;	PUNCT
ecletica-1173	477	33	nabel	nabel	NOUN
ecletica-1173	477	34	,	,	PUNCT
ecletica-1173	477	35	g.	g.	PROPN
ecletica-1173	477	36	j.	j.	PROPN
ecletica-1173	477	37	;	;	PUNCT
ecletica-1173	477	38	sodroski	sodroski	PROPN
ecletica-1173	477	39	,	,	PUNCT
ecletica-1173	477	40	j.	j.	PROPN
ecletica-1173	477	41	;	;	PUNCT
ecletica-1173	477	42	wilson	wilson	PROPN
ecletica-1173	477	43	,	,	PUNCT
ecletica-1173	477	44	i.	i.	PROPN
ecletica-1173	477	45	a.	a.	PROPN
ecletica-1173	477	46	;	;	PUNCT
ecletica-1173	477	47	wyatt	wyatt	PROPN
ecletica-1173	477	48	,	,	PUNCT
ecletica-1173	477	49	r.	r.	PROPN
ecletica-1173	477	50	t.	t.	PROPN
ecletica-1173	477	51	hiv	hiv	PROPN
ecletica-1173	477	52	vaccine	vaccine	NOUN
ecletica-1173	477	53	design	design	NOUN
ecletica-1173	477	54	and	and	CCONJ
ecletica-1173	477	55	the	the	DET
ecletica-1173	477	56	neutralizing	neutralize	VERB
ecletica-1173	477	57	antibody	antibody	NOUN
ecletica-1173	477	58	problem	problem	NOUN
ecletica-1173	477	59	.	.	PUNCT
ecletica-1173	478	1	nat	nat	NOUN
ecletica-1173	478	2	.	.	PUNCT
ecletica-1173	479	1	immunol	immunol	PROPN
ecletica-1173	479	2	.	.	PUNCT
ecletica-1173	480	1	2004	2004	NUM
ecletica-1173	480	2	,	,	PUNCT
ecletica-1173	480	3	5	5	NUM
ecletica-1173	480	4	,	,	PUNCT
ecletica-1173	480	5	233	233	NUM
ecletica-1173	480	6	–	–	PUNCT
ecletica-1173	480	7	236	236	NUM
ecletica-1173	480	8	.	.	PUNCT
ecletica-1173	480	9	https://doi.org/10.1038/ni0304-233	https://doi.org/10.1038/ni0304-233	PROPN
ecletica-1173	480	10	.	.	PUNCT
ecletica-1173	481	1	burton	burton	PROPN
ecletica-1173	481	2	,	,	PUNCT
ecletica-1173	481	3	d.	d.	PROPN
ecletica-1173	481	4	r.	r.	PROPN
ecletica-1173	481	5	;	;	PUNCT
ecletica-1173	481	6	moore	moore	PROPN
ecletica-1173	481	7	,	,	PUNCT
ecletica-1173	481	8	j.	j.	PROPN
ecletica-1173	482	1	p.	p.	PROPN
ecletica-1173	482	2	why	why	SCONJ
ecletica-1173	482	3	do	do	AUX
ecletica-1173	482	4	we	we	PRON
ecletica-1173	482	5	not	not	PART
ecletica-1173	482	6	have	have	VERB
ecletica-1173	482	7	an	an	DET
ecletica-1173	482	8	hiv	hiv	PROPN
ecletica-1173	482	9	vaccine	vaccine	NOUN
ecletica-1173	482	10	and	and	CCONJ
ecletica-1173	482	11	how	how	SCONJ
ecletica-1173	482	12	can	can	AUX
ecletica-1173	482	13	we	we	PRON
ecletica-1173	482	14	make	make	VERB
ecletica-1173	482	15	one	one	NUM
ecletica-1173	482	16	?	?	PUNCT
ecletica-1173	483	1	nat	nat	PROPN
ecletica-1173	483	2	.	.	PUNCT
ecletica-1173	484	1	med	med	PROPN
ecletica-1173	484	2	.	.	PUNCT
ecletica-1173	485	1	1998	1998	NUM
ecletica-1173	485	2	,	,	PUNCT
ecletica-1173	485	3	4	4	NUM
ecletica-1173	485	4	,	,	PUNCT
ecletica-1173	485	5	495	495	NUM
ecletica-1173	485	6	–	–	PUNCT
ecletica-1173	485	7	498	498	NUM
ecletica-1173	485	8	.	.	PUNCT
ecletica-1173	486	1	https://doi.org/10.1038/nm0598supp-495	https://doi.org/10.1038/nm0598supp-495	PROPN
ecletica-1173	486	2	.	.	PUNCT
ecletica-1173	486	3	campillos	campillos	PROPN
ecletica-1173	486	4	,	,	PUNCT
ecletica-1173	486	5	m.	m.	NOUN
ecletica-1173	486	6	;	;	PUNCT
ecletica-1173	486	7	kuhn	kuhn	PROPN
ecletica-1173	486	8	,	,	PUNCT
ecletica-1173	486	9	m.	m.	NOUN
ecletica-1173	486	10	;	;	PUNCT
ecletica-1173	486	11	gavin	gavin	PROPN
ecletica-1173	486	12	,	,	PUNCT
ecletica-1173	486	13	a.-c	a.-c	PROPN
ecletica-1173	486	14	.	.	PUNCT
ecletica-1173	486	15	;	;	PUNCT
ecletica-1173	487	1	jensen	jensen	PROPN
ecletica-1173	487	2	,	,	PUNCT
ecletica-1173	487	3	l.	l.	PROPN
ecletica-1173	487	4	j.	j.	PROPN
ecletica-1173	487	5	;	;	PUNCT
ecletica-1173	487	6	bork	bork	PROPN
ecletica-1173	487	7	,	,	PUNCT
ecletica-1173	487	8	p.	p.	NOUN
ecletica-1173	487	9	drug	drug	NOUN
ecletica-1173	487	10	target	target	NOUN
ecletica-1173	487	11	identification	identification	NOUN
ecletica-1173	487	12	using	use	VERB
ecletica-1173	487	13	side	side	NOUN
ecletica-1173	487	14	-	-	PUNCT
ecletica-1173	487	15	effect	effect	NOUN
ecletica-1173	487	16	similarity	similarity	NOUN
ecletica-1173	487	17	.	.	PUNCT
ecletica-1173	488	1	science	science	NOUN
ecletica-1173	488	2	2008	2008	NUM
ecletica-1173	488	3	,	,	PUNCT
ecletica-1173	488	4	321	321	NUM
ecletica-1173	488	5	(	(	PUNCT
ecletica-1173	488	6	5886	5886	NUM
ecletica-1173	488	7	)	)	PUNCT
ecletica-1173	488	8	,	,	PUNCT
ecletica-1173	488	9	263–266	263–266	NUM
ecletica-1173	488	10	.	.	PUNCT
ecletica-1173	489	1	https://doi.org/10.1126/science.1158140	https://doi.org/10.1126/science.1158140	NOUN
ecletica-1173	489	2	.	.	PUNCT
ecletica-1173	489	3	cardoso	cardoso	PROPN
ecletica-1173	489	4	,	,	PUNCT
ecletica-1173	489	5	e.	e.	PROPN
ecletica-1173	489	6	;	;	PUNCT
ecletica-1173	489	7	guidi	guidi	PROPN
ecletica-1173	489	8	,	,	PUNCT
ecletica-1173	489	9	m.	m.	NOUN
ecletica-1173	489	10	;	;	PUNCT
ecletica-1173	489	11	blanchet	blanchet	PROPN
ecletica-1173	489	12	,	,	PUNCT
ecletica-1173	489	13	b.	b.	PROPN
ecletica-1173	489	14	;	;	PUNCT
ecletica-1173	489	15	schneider	schneider	PROPN
ecletica-1173	489	16	,	,	PUNCT
ecletica-1173	489	17	m.	m.	NOUN
ecletica-1173	489	18	p.	p.	NOUN
ecletica-1173	489	19	;	;	PUNCT
ecletica-1173	489	20	decosterd	decosterd	PROPN
ecletica-1173	489	21	,	,	PUNCT
ecletica-1173	489	22	l.	l.	PROPN
ecletica-1173	489	23	a.	a.	PROPN
ecletica-1173	489	24	;	;	PUNCT
ecletica-1173	489	25	buclin	buclin	NOUN
ecletica-1173	489	26	,	,	PUNCT
ecletica-1173	489	27	t.	t.	PROPN
ecletica-1173	489	28	;	;	PUNCT
ecletica-1173	489	29	csajka	csajka	PROPN
ecletica-1173	489	30	,	,	PUNCT
ecletica-1173	489	31	c.	c.	PROPN
ecletica-1173	489	32	;	;	PUNCT
ecletica-1173	489	33	widmer	widmer	PROPN
ecletica-1173	489	34	,	,	PUNCT
ecletica-1173	489	35	n.	n.	PROPN
ecletica-1173	489	36	therapeutic	therapeutic	ADJ
ecletica-1173	489	37	drug	drug	NOUN
ecletica-1173	489	38	monitoring	monitoring	NOUN
ecletica-1173	489	39	of	of	ADP
ecletica-1173	489	40	targeted	target	VERB
ecletica-1173	489	41	anticancer	anticancer	NOUN
ecletica-1173	489	42	protein	protein	NOUN
ecletica-1173	489	43	kinase	kinase	VERB
ecletica-1173	489	44	inhibitors	inhibitor	NOUN
ecletica-1173	489	45	in	in	ADP
ecletica-1173	489	46	routine	routine	ADJ
ecletica-1173	489	47	clinical	clinical	ADJ
ecletica-1173	489	48	use	use	NOUN
ecletica-1173	489	49	:	:	PUNCT
ecletica-1173	489	50	a	a	DET
ecletica-1173	489	51	critical	critical	ADJ
ecletica-1173	489	52	review	review	NOUN
ecletica-1173	489	53	.	.	PUNCT
ecletica-1173	490	1	ther	ther	PROPN
ecletica-1173	490	2	.	.	PUNCT
ecletica-1173	491	1	drug	drug	PROPN
ecletica-1173	491	2	monit	monit	PROPN
ecletica-1173	491	3	.	.	PUNCT
ecletica-1173	492	1	2020	2020	NUM
ecletica-1173	492	2	,	,	PUNCT
ecletica-1173	492	3	42	42	NUM
ecletica-1173	492	4	(	(	PUNCT
ecletica-1173	492	5	1	1	NUM
ecletica-1173	492	6	)	)	PUNCT
ecletica-1173	492	7	,	,	PUNCT
ecletica-1173	492	8	33–44	33–44	NUM
ecletica-1173	492	9	.	.	PUNCT
ecletica-1173	493	1	https://doi.org/10.1097/ftd.0000000000000699	https://doi.org/10.1097/ftd.0000000000000699	PROPN
ecletica-1173	493	2	.	.	PROPN
ecletica-1173	493	3	cavasotto	cavasotto	PROPN
ecletica-1173	493	4	,	,	PUNCT
ecletica-1173	493	5	c.	c.	PROPN
ecletica-1173	493	6	n.	n.	PROPN
ecletica-1173	493	7	;	;	PUNCT
ecletica-1173	493	8	aucar	aucar	NOUN
ecletica-1173	493	9	,	,	PUNCT
ecletica-1173	493	10	m.	m.	NOUN
ecletica-1173	493	11	g.	g.	PROPN
ecletica-1173	493	12	;	;	PUNCT
ecletica-1173	493	13	adler	adler	PROPN
ecletica-1173	493	14	,	,	PUNCT
ecletica-1173	493	15	n.	n.	PROPN
ecletica-1173	493	16	s.	s.	PROPN
ecletica-1173	493	17	computational	computational	ADJ
ecletica-1173	493	18	chemistry	chemistry	NOUN
ecletica-1173	493	19	in	in	ADP
ecletica-1173	493	20	drug	drug	NOUN
ecletica-1173	493	21	lead	lead	NOUN
ecletica-1173	493	22	discovery	discovery	NOUN
ecletica-1173	493	23	and	and	CCONJ
ecletica-1173	493	24	design	design	NOUN
ecletica-1173	493	25	.	.	PUNCT
ecletica-1173	494	1	int	int	NOUN
ecletica-1173	494	2	.	.	PUNCT
ecletica-1173	495	1	j.	j.	PROPN
ecletica-1173	495	2	quantum	quantum	PROPN
ecletica-1173	495	3	chem	chem	NOUN
ecletica-1173	495	4	.	.	PUNCT
ecletica-1173	496	1	2018	2018	NUM
ecletica-1173	496	2	,	,	PUNCT
ecletica-1173	496	3	119	119	NUM
ecletica-1173	496	4	(	(	PUNCT
ecletica-1173	496	5	2	2	NUM
ecletica-1173	496	6	)	)	PUNCT
ecletica-1173	496	7	,	,	PUNCT
ecletica-1173	496	8	e25678	e25678	PROPN
ecletica-1173	496	9	.	.	PUNCT
ecletica-1173	497	1	https://doi.org/10.1002/qua.25678	https://doi.org/10.1002/qua.25678	PROPN
ecletica-1173	497	2	.	.	PROPN
ecletica-1173	497	3	chabner	chabner	PROPN
ecletica-1173	497	4	,	,	PUNCT
ecletica-1173	497	5	b.	b.	PROPN
ecletica-1173	497	6	a.	a.	PROPN
ecletica-1173	497	7	;	;	PUNCT
ecletica-1173	497	8	roberts	roberts	PROPN
ecletica-1173	497	9	junior	junior	PROPN
ecletica-1173	497	10	,	,	PUNCT
ecletica-1173	497	11	t.	t.	PROPN
ecletica-1173	497	12	g.	g.	PROPN
ecletica-1173	497	13	chemotherapy	chemotherapy	PROPN
ecletica-1173	497	14	and	and	CCONJ
ecletica-1173	497	15	the	the	DET
ecletica-1173	497	16	war	war	NOUN
ecletica-1173	497	17	on	on	ADP
ecletica-1173	497	18	cancer	cancer	NOUN
ecletica-1173	497	19	.	.	PUNCT
ecletica-1173	498	1	nat	nat	PROPN
ecletica-1173	498	2	.	.	PUNCT
ecletica-1173	499	1	rev	rev	PROPN
ecletica-1173	499	2	.	.	PROPN
ecletica-1173	500	1	cancer	cancer	PROPN
ecletica-1173	500	2	2005	2005	NUM
ecletica-1173	500	3	,	,	PUNCT
ecletica-1173	500	4	5	5	NUM
ecletica-1173	500	5	(	(	PUNCT
ecletica-1173	500	6	1	1	NUM
ecletica-1173	500	7	)	)	PUNCT
ecletica-1173	500	8	,	,	PUNCT
ecletica-1173	500	9	65–72	65–72	NUM
ecletica-1173	500	10	.	.	PUNCT
ecletica-1173	501	1	https://doi.org/10.1038/nrc1529	https://doi.org/10.1038/nrc1529	ADV
ecletica-1173	501	2	.	.	PUNCT
ecletica-1173	502	1	cheng	cheng	PROPN
ecletica-1173	502	2	,	,	PUNCT
ecletica-1173	502	3	f.	f.	PROPN
ecletica-1173	502	4	;	;	PUNCT
ecletica-1173	502	5	liu	liu	PROPN
ecletica-1173	502	6	,	,	PUNCT
ecletica-1173	502	7	c.	c.	PROPN
ecletica-1173	502	8	;	;	PUNCT
ecletica-1173	502	9	jiang	jiang	PROPN
ecletica-1173	502	10	,	,	PUNCT
ecletica-1173	502	11	j.	j.	PROPN
ecletica-1173	502	12	;	;	PUNCT
ecletica-1173	502	13	lu	lu	PROPN
ecletica-1173	502	14	,	,	PUNCT
ecletica-1173	502	15	w.	w.	PROPN
ecletica-1173	502	16	;	;	PUNCT
ecletica-1173	502	17	li	li	PROPN
ecletica-1173	502	18	,	,	PUNCT
ecletica-1173	502	19	w.	w.	PROPN
ecletica-1173	502	20	;	;	PUNCT
ecletica-1173	502	21	liu	liu	PROPN
ecletica-1173	502	22	,	,	PUNCT
ecletica-1173	502	23	g.	g.	PROPN
ecletica-1173	502	24	;	;	PUNCT
ecletica-1173	502	25	zhou	zhou	PROPN
ecletica-1173	502	26	,	,	PUNCT
ecletica-1173	502	27	w.	w.	PROPN
ecletica-1173	502	28	;	;	PUNCT
ecletica-1173	502	29	huang	huang	PROPN
ecletica-1173	502	30	,	,	PUNCT
ecletica-1173	502	31	j.	j.	PROPN
ecletica-1173	502	32	prediction	prediction	NOUN
ecletica-1173	502	33	of	of	ADP
ecletica-1173	502	34	drug	drug	NOUN
ecletica-1173	502	35	-	-	PUNCT
ecletica-1173	502	36	target	target	NOUN
ecletica-1173	502	37	interactions	interaction	NOUN
ecletica-1173	502	38	and	and	CCONJ
ecletica-1173	502	39	drug	drug	NOUN
ecletica-1173	502	40	repositioning	repositioning	NOUN
ecletica-1173	502	41	via	via	ADP
ecletica-1173	502	42	network	network	NOUN
ecletica-1173	502	43	-	-	PUNCT
ecletica-1173	502	44	based	base	VERB
ecletica-1173	502	45	inference	inference	NOUN
ecletica-1173	502	46	.	.	PUNCT
ecletica-1173	503	1	plos	plos	PROPN
ecletica-1173	503	2	comput	comput	PROPN
ecletica-1173	503	3	.	.	PUNCT
ecletica-1173	504	1	biol	biol	PROPN
ecletica-1173	504	2	.	.	PUNCT
ecletica-1173	505	1	2012	2012	NUM
ecletica-1173	505	2	,	,	PUNCT
ecletica-1173	505	3	8	8	NUM
ecletica-1173	505	4	(	(	PUNCT
ecletica-1173	505	5	5	5	NUM
ecletica-1173	505	6	)	)	PUNCT
ecletica-1173	505	7	,	,	PUNCT
ecletica-1173	505	8	e1002503	e1002503	NOUN
ecletica-1173	505	9	.	.	PROPN
ecletica-1173	505	10	https://doi.org/10.1371/journal.pcbi.1002503	https://doi.org/10.1371/journal.pcbi.1002503	NOUN
ecletica-1173	505	11	.	.	PUNCT
ecletica-1173	506	1	chirita	chirita	PROPN
ecletica-1173	506	2	-	-	PUNCT
ecletica-1173	506	3	emandi	emandi	NOUN
ecletica-1173	506	4	,	,	PUNCT
ecletica-1173	506	5	a.	a.	NOUN
ecletica-1173	506	6	;	;	PUNCT
ecletica-1173	506	7	niculescu	niculescu	PROPN
ecletica-1173	506	8	,	,	PUNCT
ecletica-1173	506	9	m.	m.	NOUN
ecletica-1173	506	10	methods	method	NOUN
ecletica-1173	506	11	for	for	ADP
ecletica-1173	506	12	global	global	ADJ
ecletica-1173	506	13	nutrigenomics	nutrigenomic	NOUN
ecletica-1173	506	14	and	and	CCONJ
ecletica-1173	506	15	precision	precision	NOUN
ecletica-1173	506	16	nutrition	nutrition	NOUN
ecletica-1173	506	17	.	.	PUNCT
ecletica-1173	507	1	in	in	ADP
ecletica-1173	507	2	principles	principle	NOUN
ecletica-1173	507	3	of	of	ADP
ecletica-1173	507	4	nutrigenetics	nutrigenetic	NOUN
ecletica-1173	507	5	and	and	CCONJ
ecletica-1173	507	6	nutrigenomics	nutrigenomic	NOUN
ecletica-1173	507	7	:	:	PUNCT
ecletica-1173	507	8	fundamentals	fundamental	NOUN
ecletica-1173	507	9	for	for	ADP
ecletica-1173	507	10	individualized	individualized	ADJ
ecletica-1173	507	11	nutrition	nutrition	NOUN
ecletica-1173	507	12	;	;	PUNCT
ecletica-1173	507	13	academic	academic	ADJ
ecletica-1173	507	14	press	press	NOUN
ecletica-1173	507	15	,	,	PUNCT
ecletica-1173	507	16	2020	2020	NUM
ecletica-1173	507	17	;	;	PUNCT
ecletica-1173	507	18	pp	pp	ADP
ecletica-1173	507	19	49–58	49–58	NUM
ecletica-1173	507	20	.	.	PUNCT
ecletica-1173	508	1	https://doi.org/10.1016/b978-0-12-804572-5.00007-0	https://doi.org/10.1016/b978-0-12-804572-5.00007-0	PROPN
ecletica-1173	508	2	.	.	PUNCT
ecletica-1173	509	1	crick	crick	PROPN
ecletica-1173	509	2	,	,	PUNCT
ecletica-1173	509	3	f.	f.	PROPN
ecletica-1173	509	4	of	of	ADP
ecletica-1173	509	5	molecules	molecule	NOUN
ecletica-1173	509	6	and	and	CCONJ
ecletica-1173	509	7	men	man	NOUN
ecletica-1173	509	8	;	;	PUNCT
ecletica-1173	509	9	university	university	NOUN
ecletica-1173	509	10	of	of	ADP
ecletica-1173	509	11	washington	washington	PROPN
ecletica-1173	509	12	press	press	PROPN
ecletica-1173	509	13	,	,	PUNCT
ecletica-1173	509	14	1966	1966	NUM
ecletica-1173	509	15	.	.	PUNCT
ecletica-1173	510	1	davis	davis	PROPN
ecletica-1173	510	2	,	,	PUNCT
ecletica-1173	510	3	c.	c.	PROPN
ecletica-1173	510	4	d.	d.	PROPN
ecletica-1173	510	5	;	;	PUNCT
ecletica-1173	510	6	hord	hord	PROPN
ecletica-1173	510	7	,	,	PUNCT
ecletica-1173	510	8	n.	n.	PROPN
ecletica-1173	510	9	g.	g.	PROPN
ecletica-1173	510	10	nutritional	nutritional	ADJ
ecletica-1173	510	11	“	"	PUNCT
ecletica-1173	510	12	omics	omic	NOUN
ecletica-1173	510	13	”	"	PUNCT
ecletica-1173	510	14	technologies	technology	NOUN
ecletica-1173	510	15	for	for	ADP
ecletica-1173	510	16	elucidating	elucidate	VERB
ecletica-1173	510	17	the	the	DET
ecletica-1173	510	18	role(s	role(s	PROPN
ecletica-1173	510	19	)	)	PUNCT
ecletica-1173	510	20	of	of	ADP
ecletica-1173	510	21	bioactive	bioactive	ADJ
ecletica-1173	510	22	food	food	NOUN
ecletica-1173	510	23	components	component	NOUN
ecletica-1173	510	24	in	in	ADP
ecletica-1173	510	25	colon	colon	NOUN
ecletica-1173	510	26	cancer	cancer	NOUN
ecletica-1173	510	27	prevention	prevention	NOUN
ecletica-1173	510	28	.	.	PUNCT
ecletica-1173	511	1	j.	j.	PROPN
ecletica-1173	511	2	nutr	nutr	PROPN
ecletica-1173	511	3	.	.	PROPN
ecletica-1173	511	4	2005	2005	NUM
ecletica-1173	511	5	,	,	PUNCT
ecletica-1173	511	6	135	135	NUM
ecletica-1173	511	7	(	(	PUNCT
ecletica-1173	511	8	11	11	NUM
ecletica-1173	511	9	)	)	PUNCT
ecletica-1173	511	10	,	,	PUNCT
ecletica-1173	511	11	2694	2694	NUM
ecletica-1173	511	12	–	–	PUNCT
ecletica-1173	511	13	2697	2697	NUM
ecletica-1173	511	14	.	.	PUNCT
ecletica-1173	512	1	https://doi.org/10.1093/jn/135.11.2694	https://doi.org/10.1093/jn/135.11.2694	PROPN
ecletica-1173	512	2	.	.	PUNCT
ecletica-1173	512	3	dirac	dirac	PROPN
ecletica-1173	512	4	,	,	PUNCT
ecletica-1173	512	5	p.	p.	NOUN
ecletica-1173	512	6	a.	a.	NOUN
ecletica-1173	512	7	m.	m.	NOUN
ecletica-1173	512	8	quantum	quantum	NOUN
ecletica-1173	512	9	mechanics	mechanic	NOUN
ecletica-1173	512	10	of	of	ADP
ecletica-1173	512	11	many	many	ADJ
ecletica-1173	512	12	-	-	PUNCT
ecletica-1173	512	13	electron	electron	NOUN
ecletica-1173	512	14	systems	system	NOUN
ecletica-1173	512	15	.	.	PUNCT
ecletica-1173	513	1	proc	proc	PROPN
ecletica-1173	513	2	.	.	PUNCT
ecletica-1173	514	1	r.	r.	PROPN
ecletica-1173	514	2	soc	soc	PROPN
ecletica-1173	514	3	.	.	PUNCT
ecletica-1173	515	1	a	a	DET
ecletica-1173	515	2	1929	1929	NUM
ecletica-1173	515	3	,	,	PUNCT
ecletica-1173	515	4	123	123	NUM
ecletica-1173	515	5	(	(	PUNCT
ecletica-1173	515	6	792	792	NUM
ecletica-1173	515	7	)	)	PUNCT
ecletica-1173	515	8	,	,	PUNCT
ecletica-1173	515	9	714–733	714–733	NUM
ecletica-1173	515	10	.	.	PUNCT
ecletica-1173	516	1	https://doi.org/10.1098/rspa.1929.0094	https://doi.org/10.1098/rspa.1929.0094	PROPN
ecletica-1173	516	2	.	.	PUNCT
ecletica-1173	516	3	dolberg	dolberg	PROPN
ecletica-1173	516	4	,	,	PUNCT
ecletica-1173	516	5	d.	d.	PROPN
ecletica-1173	516	6	s.	s.	PROPN
ecletica-1173	516	7	;	;	PUNCT
ecletica-1173	516	8	bissell	bissell	PROPN
ecletica-1173	516	9	,	,	PUNCT
ecletica-1173	516	10	m.	m.	NOUN
ecletica-1173	516	11	j.	j.	PROPN
ecletica-1173	516	12	inability	inability	PROPN
ecletica-1173	516	13	of	of	ADP
ecletica-1173	516	14	rous	rous	ADJ
ecletica-1173	516	15	sarcoma	sarcoma	NOUN
ecletica-1173	516	16	virus	virus	NOUN
ecletica-1173	516	17	to	to	PART
ecletica-1173	516	18	cause	cause	VERB
ecletica-1173	516	19	sarcomas	sarcoma	NOUN
ecletica-1173	516	20	in	in	ADP
ecletica-1173	516	21	the	the	DET
ecletica-1173	516	22	avian	avian	ADJ
ecletica-1173	516	23	embryo	embryo	NOUN
ecletica-1173	516	24	.	.	PUNCT
ecletica-1173	517	1	nature	nature	NOUN
ecletica-1173	517	2	1984	1984	NUM
ecletica-1173	517	3	,	,	PUNCT
ecletica-1173	517	4	309	309	NUM
ecletica-1173	517	5	,	,	PUNCT
ecletica-1173	517	6	552–556	552–556	NUM
ecletica-1173	517	7	.	.	PUNCT
ecletica-1173	518	1	https://doi.org/10.1038/309552a0	https://doi.org/10.1038/309552a0	PROPN
ecletica-1173	518	2	.	.	PUNCT
ecletica-1173	518	3	drews	drews	PROPN
ecletica-1173	518	4	,	,	PUNCT
ecletica-1173	518	5	j.	j.	PROPN
ecletica-1173	518	6	strategic	strategic	ADJ
ecletica-1173	518	7	trends	trend	NOUN
ecletica-1173	518	8	in	in	ADP
ecletica-1173	518	9	the	the	DET
ecletica-1173	518	10	drug	drug	NOUN
ecletica-1173	518	11	industry	industry	NOUN
ecletica-1173	518	12	.	.	PUNCT
ecletica-1173	519	1	drug	drug	NOUN
ecletica-1173	519	2	discov	discov	NOUN
ecletica-1173	519	3	.	.	PUNCT
ecletica-1173	520	1	today	today	NOUN
ecletica-1173	520	2	2003	2003	NUM
ecletica-1173	520	3	,	,	PUNCT
ecletica-1173	520	4	8	8	NUM
ecletica-1173	520	5	(	(	PUNCT
ecletica-1173	520	6	9	9	NUM
ecletica-1173	520	7	)	)	PUNCT
ecletica-1173	520	8	,	,	PUNCT
ecletica-1173	520	9	411–420	411–420	NUM
ecletica-1173	520	10	.	.	PUNCT
ecletica-1173	521	1	https://doi.org/10.1016/s13596446(03)02690-4	https://doi.org/10.1016/s13596446(03)02690-4	PROPN
ecletica-1173	521	2	.	.	PUNCT
ecletica-1173	522	1	ecker	ecker	PROPN
ecletica-1173	522	2	,	,	PUNCT
ecletica-1173	522	3	d.	d.	PROPN
ecletica-1173	522	4	m.	m.	PROPN
ecletica-1173	522	5	;	;	PUNCT
ecletica-1173	522	6	jones	jones	PROPN
ecletica-1173	522	7	,	,	PUNCT
ecletica-1173	522	8	s.	s.	PROPN
ecletica-1173	522	9	d.	d.	PROPN
ecletica-1173	522	10	;	;	PUNCT
ecletica-1173	522	11	levine	levine	PROPN
ecletica-1173	522	12	,	,	PUNCT
ecletica-1173	522	13	h.	h.	PROPN
ecletica-1173	522	14	l.	l.	PROPN
ecletica-1173	522	15	the	the	DET
ecletica-1173	522	16	therapeutic	therapeutic	ADJ
ecletica-1173	522	17	monoclonal	monoclonal	NOUN
ecletica-1173	522	18	antibody	antibody	NOUN
ecletica-1173	522	19	market	market	NOUN
ecletica-1173	522	20	.	.	PUNCT
ecletica-1173	523	1	mabs	mab	NOUN
ecletica-1173	523	2	2015	2015	NUM
ecletica-1173	523	3	,	,	PUNCT
ecletica-1173	523	4	7	7	NUM
ecletica-1173	523	5	(	(	PUNCT
ecletica-1173	523	6	1	1	NUM
ecletica-1173	523	7	)	)	PUNCT
ecletica-1173	523	8	,	,	PUNCT
ecletica-1173	523	9	9–14	9–14	PROPN
ecletica-1173	523	10	.	.	PUNCT
ecletica-1173	524	1	https://doi.org/10.4161/19420862.2015.989042	https://doi.org/10.4161/19420862.2015.989042	PROPN
ecletica-1173	524	2	.	.	PROPN
ecletica-1173	524	3	faratian	faratian	PROPN
ecletica-1173	524	4	,	,	PUNCT
ecletica-1173	524	5	d.	d.	PROPN
ecletica-1173	524	6	;	;	PUNCT
ecletica-1173	524	7	clyde	clyde	PROPN
ecletica-1173	524	8	,	,	PUNCT
ecletica-1173	524	9	r.	r.	PROPN
ecletica-1173	524	10	g.	g.	PROPN
ecletica-1173	524	11	;	;	PUNCT
ecletica-1173	524	12	crawford	crawford	PROPN
ecletica-1173	524	13	,	,	PUNCT
ecletica-1173	524	14	j.	j.	PROPN
ecletica-1173	524	15	w.	w.	PROPN
ecletica-1173	524	16	;	;	PUNCT
ecletica-1173	524	17	harrison	harrison	PROPN
ecletica-1173	524	18	,	,	PUNCT
ecletica-1173	524	19	d.	d.	PROPN
ecletica-1173	524	20	j.	j.	PROPN
ecletica-1173	524	21	systems	systems	PROPN
ecletica-1173	524	22	pathology	pathology	PROPN
ecletica-1173	524	23	—	—	PUNCT
ecletica-1173	524	24	taking	take	VERB
ecletica-1173	524	25	molecular	molecular	ADJ
ecletica-1173	524	26	pathology	pathology	NOUN
ecletica-1173	524	27	into	into	ADP
ecletica-1173	524	28	a	a	DET
ecletica-1173	524	29	new	new	ADJ
ecletica-1173	524	30	dimension	dimension	NOUN
ecletica-1173	524	31	.	.	PUNCT
ecletica-1173	525	1	nat	nat	PROPN
ecletica-1173	525	2	.	.	PUNCT
ecletica-1173	526	1	rev	rev	PROPN
ecletica-1173	526	2	.	.	PROPN
ecletica-1173	527	1	clin	clin	PROPN
ecletica-1173	527	2	.	.	PUNCT
ecletica-1173	528	1	oncol	oncol	PROPN
ecletica-1173	528	2	.	.	PUNCT
ecletica-1173	529	1	2009	2009	NUM
ecletica-1173	529	2	,	,	PUNCT
ecletica-1173	529	3	6	6	NUM
ecletica-1173	529	4	(	(	PUNCT
ecletica-1173	529	5	8)	8)	NUM
ecletica-1173	529	6	,	,	PUNCT
ecletica-1173	529	7	455–464	455–464	NUM
ecletica-1173	529	8	.	.	PUNCT
ecletica-1173	530	1	https://doi.org/10.1038/nrclinonc.2009.102	https://doi.org/10.1038/nrclinonc.2009.102	PROPN
ecletica-1173	530	2	.	.	PUNCT
ecletica-1173	531	1	fardet	fardet	NOUN
ecletica-1173	531	2	,	,	PUNCT
ecletica-1173	531	3	a.	a.	NOUN
ecletica-1173	531	4	food	food	PROPN
ecletica-1173	531	5	health	health	NOUN
ecletica-1173	531	6	potential	potential	NOUN
ecletica-1173	531	7	is	be	AUX
ecletica-1173	531	8	primarily	primarily	ADV
ecletica-1173	531	9	due	due	ADJ
ecletica-1173	531	10	to	to	ADP
ecletica-1173	531	11	its	its	PRON
ecletica-1173	531	12	matrix	matrix	NOUN
ecletica-1173	531	13	structure	structure	NOUN
ecletica-1173	531	14	,	,	PUNCT
ecletica-1173	531	15	then	then	ADV
ecletica-1173	531	16	nutrient	nutrient	ADJ
ecletica-1173	531	17	composition	composition	NOUN
ecletica-1173	531	18	:	:	PUNCT
ecletica-1173	531	19	a	a	DET
ecletica-1173	531	20	new	new	ADJ
ecletica-1173	531	21	paradigm	paradigm	NOUN
ecletica-1173	531	22	for	for	ADP
ecletica-1173	531	23	food	food	NOUN
ecletica-1173	531	24	classification	classification	NOUN
ecletica-1173	531	25	according	accord	VERB
ecletica-1173	531	26	to	to	ADP
ecletica-1173	531	27	technological	technological	ADJ
ecletica-1173	531	28	processes	process	NOUN
ecletica-1173	531	29	applied	apply	VERB
ecletica-1173	531	30	.	.	PUNCT
ecletica-1173	532	1	j	j	PROPN
ecletica-1173	532	2	nutr	nutr	PROPN
ecletica-1173	532	3	.	.	PROPN
ecletica-1173	532	4	health	health	PROPN
ecletica-1173	532	5	food	food	PROPN
ecletica-1173	532	6	eng	eng	PROPN
ecletica-1173	532	7	.	.	PROPN
ecletica-1173	532	8	2014	2014	NUM
ecletica-1173	532	9	,	,	PUNCT
ecletica-1173	532	10	1	1	NUM
ecletica-1173	532	11	(	(	PUNCT
ecletica-1173	532	12	5	5	NUM
ecletica-1173	532	13	)	)	PUNCT
ecletica-1173	532	14	,	,	PUNCT
ecletica-1173	532	15	208	208	NUM
ecletica-1173	532	16	-	-	SYM
ecletica-1173	532	17	209	209	NUM
ecletica-1173	532	18	.	.	PUNCT
ecletica-1173	533	1	https://doi.org/10.15406/jnhfe.2014.01.00031	https://doi.org/10.15406/jnhfe.2014.01.00031	X
ecletica-1173	533	2	.	.	PUNCT
ecletica-1173	534	1	fardet	fardet	PROPN
ecletica-1173	534	2	,	,	PUNCT
ecletica-1173	534	3	a.	a.	NOUN
ecletica-1173	534	4	;	;	PUNCT
ecletica-1173	534	5	rock	rock	PROPN
ecletica-1173	534	6	,	,	PUNCT
ecletica-1173	534	7	e.	e.	PROPN
ecletica-1173	534	8	toward	toward	ADP
ecletica-1173	534	9	a	a	DET
ecletica-1173	534	10	new	new	ADJ
ecletica-1173	534	11	philosophy	philosophy	NOUN
ecletica-1173	534	12	of	of	ADP
ecletica-1173	534	13	preventive	preventive	ADJ
ecletica-1173	534	14	nutrition	nutrition	NOUN
ecletica-1173	534	15	:	:	PUNCT
ecletica-1173	534	16	from	from	ADP
ecletica-1173	534	17	a	a	DET
ecletica-1173	534	18	reductionist	reductionist	NOUN
ecletica-1173	534	19	to	to	ADP
ecletica-1173	534	20	a	a	DET
ecletica-1173	534	21	holistic	holistic	ADJ
ecletica-1173	534	22	paradigm	paradigm	NOUN
ecletica-1173	534	23	to	to	PART
ecletica-1173	534	24	improve	improve	VERB
ecletica-1173	534	25	nutritional	nutritional	ADJ
ecletica-1173	534	26	recommendations	recommendation	NOUN
ecletica-1173	534	27	.	.	PUNCT
ecletica-1173	535	1	adv	adv	PROPN
ecletica-1173	535	2	.	.	PUNCT
ecletica-1173	536	1	nutr	nutr	PROPN
ecletica-1173	536	2	.	.	PROPN
ecletica-1173	536	3	2014	2014	NUM
ecletica-1173	536	4	,	,	PUNCT
ecletica-1173	536	5	5	5	NUM
ecletica-1173	536	6	(	(	PUNCT
ecletica-1173	536	7	4	4	NUM
ecletica-1173	536	8	)	)	PUNCT
ecletica-1173	536	9	430–446	430–446	NUM
ecletica-1173	536	10	.	.	PUNCT
ecletica-1173	537	1	https://doi.org/10.3945/an.114.006122	https://doi.org/10.3945/an.114.006122	NOUN
ecletica-1173	537	2	.	.	PUNCT
ecletica-1173	538	1	fojo	fojo	NOUN
ecletica-1173	538	2	,	,	PUNCT
ecletica-1173	538	3	t.	t.	NOUN
ecletica-1173	538	4	commentary	commentary	NOUN
ecletica-1173	538	5	:	:	PUNCT
ecletica-1173	538	6	novel	novel	ADJ
ecletica-1173	538	7	therapies	therapy	NOUN
ecletica-1173	538	8	for	for	ADP
ecletica-1173	538	9	cancer	cancer	NOUN
ecletica-1173	538	10	:	:	PUNCT
ecletica-1173	538	11	why	why	SCONJ
ecletica-1173	538	12	dirty	dirty	ADJ
ecletica-1173	538	13	might	might	AUX
ecletica-1173	538	14	be	be	AUX
ecletica-1173	538	15	better	well	ADJ
ecletica-1173	538	16	.	.	PUNCT
ecletica-1173	539	1	oncologist	oncologist	NOUN
ecletica-1173	539	2	2008	2008	NUM
ecletica-1173	539	3	,	,	PUNCT
ecletica-1173	539	4	13	13	NUM
ecletica-1173	539	5	(	(	PUNCT
ecletica-1173	539	6	3	3	NUM
ecletica-1173	539	7	)	)	PUNCT
ecletica-1173	539	8	,	,	PUNCT
ecletica-1173	539	9	277–283	277–283	NUM
ecletica-1173	539	10	.	.	PUNCT
ecletica-1173	540	1	https://doi.org/10.1634/theoncologist.2007-0090	https://doi.org/10.1634/theoncologist.2007-0090	NOUN
ecletica-1173	540	2	.	.	PUNCT
ecletica-1173	541	1	gershell	gershell	NOUN
ecletica-1173	541	2	,	,	PUNCT
ecletica-1173	541	3	l.	l.	PROPN
ecletica-1173	541	4	j.	j.	PROPN
ecletica-1173	541	5	;	;	PUNCT
ecletica-1173	541	6	atkins	atkins	PROPN
ecletica-1173	541	7	,	,	PUNCT
ecletica-1173	541	8	j.	j.	PROPN
ecletica-1173	541	9	h.	h.	PROPN
ecletica-1173	542	1	a	a	DET
ecletica-1173	542	2	brief	brief	ADJ
ecletica-1173	542	3	history	history	NOUN
ecletica-1173	542	4	of	of	ADP
ecletica-1173	542	5	novel	novel	ADJ
ecletica-1173	542	6	drug	drug	NOUN
ecletica-1173	542	7	discovery	discovery	NOUN
ecletica-1173	542	8	technologies	technology	NOUN
ecletica-1173	542	9	.	.	PUNCT
ecletica-1173	543	1	nat	nat	PROPN
ecletica-1173	543	2	.	.	PUNCT
ecletica-1173	544	1	rev	rev	PROPN
ecletica-1173	544	2	.	.	PROPN
ecletica-1173	544	3	drug	drug	NOUN
ecletica-1173	544	4	discov	discov	NOUN
ecletica-1173	544	5	.	.	PUNCT
ecletica-1173	545	1	2003	2003	NUM
ecletica-1173	545	2	,	,	PUNCT
ecletica-1173	545	3	2	2	NUM
ecletica-1173	545	4	,	,	PUNCT
ecletica-1173	545	5	321–327	321–327	NUM
ecletica-1173	545	6	.	.	PUNCT
ecletica-1173	546	1	https://doi.org/10.1038/nrd1064	https://doi.org/10.1038/nrd1064	PROPN
ecletica-1173	546	2	.	.	PUNCT
ecletica-1173	547	1	glassman	glassman	PROPN
ecletica-1173	547	2	,	,	PUNCT
ecletica-1173	547	3	r.	r.	PROPN
ecletica-1173	547	4	h.	h.	PROPN
ecletica-1173	547	5	;	;	PUNCT
ecletica-1173	547	6	sun	sun	NOUN
ecletica-1173	547	7	,	,	PUNCT
ecletica-1173	547	8	a.	a.	PROPN
ecletica-1173	547	9	y.	y.	PROPN
ecletica-1173	547	10	biotechnology	biotechnology	PROPN
ecletica-1173	547	11	:	:	PUNCT
ecletica-1173	547	12	identifying	identify	VERB
ecletica-1173	547	13	advances	advance	NOUN
ecletica-1173	547	14	from	from	ADP
ecletica-1173	547	15	the	the	DET
ecletica-1173	547	16	hype	hype	NOUN
ecletica-1173	547	17	.	.	PUNCT
ecletica-1173	548	1	nat	nat	PROPN
ecletica-1173	548	2	.	.	PUNCT
ecletica-1173	549	1	rev	rev	PROPN
ecletica-1173	549	2	.	.	PROPN
ecletica-1173	549	3	drug	drug	NOUN
ecletica-1173	549	4	discov	discov	NOUN
ecletica-1173	549	5	.	.	PUNCT
ecletica-1173	550	1	2004	2004	NUM
ecletica-1173	550	2	,	,	PUNCT
ecletica-1173	550	3	3	3	NUM
ecletica-1173	550	4	,	,	PUNCT
ecletica-1173	550	5	177–183	177–183	NUM
ecletica-1173	550	6	.	.	PUNCT
ecletica-1173	550	7	https://doi.org/10.1038/nrd1309	https://doi.org/10.1038/nrd1309	PROPN
ecletica-1173	550	8	.	.	PUNCT
ecletica-1173	551	1	goh	goh	PROPN
ecletica-1173	551	2	,	,	PUNCT
ecletica-1173	551	3	c.-s	c.-	NOUN
ecletica-1173	551	4	.	.	PUNCT
ecletica-1173	551	5	;	;	PUNCT
ecletica-1173	551	6	milburn	milburn	PROPN
ecletica-1173	551	7	,	,	PUNCT
ecletica-1173	551	8	d.	d.	PROPN
ecletica-1173	551	9	;	;	PUNCT
ecletica-1173	551	10	gerstein	gerstein	PROPN
ecletica-1173	551	11	,	,	PUNCT
ecletica-1173	551	12	m.	m.	NOUN
ecletica-1173	551	13	conformational	conformational	ADJ
ecletica-1173	551	14	changes	change	NOUN
ecletica-1173	551	15	associated	associate	VERB
ecletica-1173	551	16	with	with	ADP
ecletica-1173	551	17	protein	protein	NOUN
ecletica-1173	551	18	-	-	PUNCT
ecletica-1173	551	19	protein	protein	NOUN
ecletica-1173	551	20	interactions	interaction	NOUN
ecletica-1173	551	21	.	.	PUNCT
ecletica-1173	552	1	curr	curr	PROPN
ecletica-1173	552	2	.	.	PUNCT
ecletica-1173	553	1	opin	opin	NOUN
ecletica-1173	553	2	.	.	PUNCT
ecletica-1173	553	3	struct	struct	NOUN
ecletica-1173	553	4	.	.	PUNCT
ecletica-1173	554	1	biol	biol	PROPN
ecletica-1173	554	2	.	.	PUNCT
ecletica-1173	555	1	2004	2004	NUM
ecletica-1173	555	2	,	,	PUNCT
ecletica-1173	555	3	14	14	NUM
ecletica-1173	555	4	(	(	PUNCT
ecletica-1173	555	5	1	1	NUM
ecletica-1173	555	6	)	)	PUNCT
ecletica-1173	555	7	,	,	PUNCT
ecletica-1173	555	8	104–109	104–109	NUM
ecletica-1173	555	9	.	.	PUNCT
ecletica-1173	556	1	https://doi.org/10.1016/j.sbi.2004.01.005	https://doi.org/10.1016/j.sbi.2004.01.005	PROPN
ecletica-1173	556	2	.	.	PUNCT
ecletica-1173	557	1	hagios	hagio	NOUN
ecletica-1173	557	2	,	,	PUNCT
ecletica-1173	557	3	c.	c.	PROPN
ecletica-1173	557	4	;	;	PUNCT
ecletica-1173	557	5	lochter	lochter	PROPN
ecletica-1173	557	6	,	,	PUNCT
ecletica-1173	557	7	a.	a.	NOUN
ecletica-1173	557	8	;	;	PUNCT
ecletica-1173	557	9	bissell	bissell	NOUN
ecletica-1173	557	10	,	,	PUNCT
ecletica-1173	557	11	m.	m.	NOUN
ecletica-1173	557	12	j.	j.	PROPN
ecletica-1173	557	13	tissue	tissue	NOUN
ecletica-1173	557	14	architecture	architecture	NOUN
ecletica-1173	557	15	:	:	PUNCT
ecletica-1173	557	16	the	the	DET
ecletica-1173	557	17	ultimate	ultimate	ADJ
ecletica-1173	557	18	regulator	regulator	NOUN
ecletica-1173	557	19	of	of	ADP
ecletica-1173	557	20	epithelial	epithelial	ADJ
ecletica-1173	557	21	function	function	NOUN
ecletica-1173	557	22	?	?	PUNCT
ecletica-1173	558	1	phil	phil	PROPN
ecletica-1173	558	2	.	.	PUNCT
ecletica-1173	559	1	trans	trans	PROPN
ecletica-1173	559	2	.	.	PUNCT
ecletica-1173	559	3	r.	r.	PROPN
ecletica-1173	559	4	http://revista.iq.unesp.br/ojs/index.php/ecletica/index	http://revista.iq.unesp.br/ojs/index.php/ecletica/index	PROPN
ecletica-1173	559	5	https://doi.org/10.26850/1678-4618eqj.v46.3.2021.p17-32	https://doi.org/10.26850/1678-4618eqj.v46.3.2021.p17-32	PROPN
ecletica-1173	559	6	https://doi.org/10.1002/andp.19273892002	https://doi.org/10.1002/andp.19273892002	NOUN
ecletica-1173	559	7	https://doi.org/10.1002/andp.19273892002	https://doi.org/10.1002/andp.19273892002	NOUN
ecletica-1173	559	8	https://doi.org/10.1002/andp.19273892002	https://doi.org/10.1002/andp.19273892002	NOUN
ecletica-1173	559	9	https://doi.org/10.1152/physiologyonline.2001.16.4.171	https://doi.org/10.1152/physiologyonline.2001.16.4.171	PROPN
ecletica-1173	559	10	https://doi.org/10.1152/physiologyonline.2001.16.4.171	https://doi.org/10.1152/physiologyonline.2001.16.4.171	PROPN
ecletica-1173	559	11	https://doi.org/10.1152/physiologyonline.2001.16.4.171	https://doi.org/10.1152/physiologyonline.2001.16.4.171	PROPN
ecletica-1173	559	12	https://doi.org/10.1002/9783527654307.ch1	https://doi.org/10.1002/9783527654307.ch1	PROPN
ecletica-1173	559	13	https://doi.org/10.1002/9783527654307.ch1	https://doi.org/10.1002/9783527654307.ch1	PROPN
ecletica-1173	559	14	https://doi.org/10.1002/9783527654307.ch1	https://doi.org/10.1002/9783527654307.ch1	PROPN
ecletica-1173	559	15	https://doi.org/10.1038/ni0304-233	https://doi.org/10.1038/ni0304-233	VERB
ecletica-1173	559	16	https://doi.org/10.1038/ni0304-233	https://doi.org/10.1038/ni0304-233	NOUN
ecletica-1173	559	17	https://doi.org/10.1038/ni0304-233	https://doi.org/10.1038/ni0304-233	NOUN
ecletica-1173	559	18	https://doi.org/10.1038/ni0304-233	https://doi.org/10.1038/ni0304-233	NOUN
ecletica-1173	559	19	https://doi.org/10.1038/ni0304-233	https://doi.org/10.1038/ni0304-233	X
ecletica-1173	559	20	https://doi.org/10.1038/nm0598supp-495	https://doi.org/10.1038/nm0598supp-495	ADJ
ecletica-1173	559	21	https://doi.org/10.1038/nm0598supp-495	https://doi.org/10.1038/nm0598supp-495	ADJ
ecletica-1173	559	22	https://doi.org/10.1038/nm0598supp-495	https://doi.org/10.1038/nm0598supp-495	ADJ
ecletica-1173	559	23	https://doi.org/10.1126/science.1158140	https://doi.org/10.1126/science.1158140	NOUN
ecletica-1173	559	24	https://doi.org/10.1126/science.1158140	https://doi.org/10.1126/science.1158140	NOUN
ecletica-1173	559	25	https://doi.org/10.1126/science.1158140	https://doi.org/10.1126/science.1158140	NOUN
ecletica-1173	559	26	https://doi.org/10.1126/science.1158140	https://doi.org/10.1126/science.1158140	NOUN
ecletica-1173	559	27	https://doi.org/10.1097/ftd.0000000000000699	https://doi.org/10.1097/ftd.0000000000000699	PROPN
ecletica-1173	559	28	https://doi.org/10.1097/ftd.0000000000000699	https://doi.org/10.1097/ftd.0000000000000699	PROPN
ecletica-1173	559	29	https://doi.org/10.1097/ftd.0000000000000699	https://doi.org/10.1097/ftd.0000000000000699	PROPN
ecletica-1173	559	30	https://doi.org/10.1097/ftd.0000000000000699	https://doi.org/10.1097/ftd.0000000000000699	PROPN
ecletica-1173	559	31	https://doi.org/10.1097/ftd.0000000000000699	https://doi.org/10.1097/ftd.0000000000000699	PROPN
ecletica-1173	559	32	https://doi.org/10.1097/ftd.0000000000000699	https://doi.org/10.1097/ftd.0000000000000699	PROPN
ecletica-1173	559	33	https://doi.org/10.1002/qua.25678	https://doi.org/10.1002/qua.25678	PROPN
ecletica-1173	559	34	https://doi.org/10.1002/qua.25678	https://doi.org/10.1002/qua.25678	PROPN
ecletica-1173	559	35	https://doi.org/10.1002/qua.25678	https://doi.org/10.1002/qua.25678	PROPN
ecletica-1173	559	36	https://doi.org/10.1002/qua.25678	https://doi.org/10.1002/qua.25678	PROPN
ecletica-1173	559	37	https://doi.org/10.1038/nrc1529	https://doi.org/10.1038/nrc1529	ADV
ecletica-1173	559	38	https://doi.org/10.1038/nrc1529	https://doi.org/10.1038/nrc1529	ADV
ecletica-1173	559	39	https://doi.org/10.1038/nrc1529	https://doi.org/10.1038/nrc1529	ADV
ecletica-1173	559	40	https://doi.org/10.1371/journal.pcbi.1002503	https://doi.org/10.1371/journal.pcbi.1002503	ADV
ecletica-1173	559	41	https://doi.org/10.1371/journal.pcbi.1002503	https://doi.org/10.1371/journal.pcbi.1002503	ADV
ecletica-1173	559	42	https://doi.org/10.1371/journal.pcbi.1002503	https://doi.org/10.1371/journal.pcbi.1002503	NOUN
ecletica-1173	559	43	https://doi.org/10.1371/journal.pcbi.1002503	https://doi.org/10.1371/journal.pcbi.1002503	NOUN
ecletica-1173	559	44	https://doi.org/10.1371/journal.pcbi.1002503	https://doi.org/10.1371/journal.pcbi.1002503	NOUN
ecletica-1173	559	45	https://doi.org/10.1016/b978-0-12-804572-5.00007-0	https://doi.org/10.1016/b978-0-12-804572-5.00007-0	PROPN
ecletica-1173	559	46	https://doi.org/10.1016/b978-0-12-804572-5.00007-0	https://doi.org/10.1016/b978-0-12-804572-5.00007-0	PROPN
ecletica-1173	559	47	https://doi.org/10.1016/b978-0-12-804572-5.00007-0	https://doi.org/10.1016/b978-0-12-804572-5.00007-0	PROPN
ecletica-1173	559	48	https://doi.org/10.1016/b978-0-12-804572-5.00007-0	https://doi.org/10.1016/b978-0-12-804572-5.00007-0	PROPN
ecletica-1173	559	49	https://doi.org/10.1016/b978-0-12-804572-5.00007-0	https://doi.org/10.1016/b978-0-12-804572-5.00007-0	PROPN
ecletica-1173	559	50	https://doi.org/10.1093/jn/135.11.2694	https://doi.org/10.1093/jn/135.11.2694	PROPN
ecletica-1173	559	51	https://doi.org/10.1093/jn/135.11.2694	https://doi.org/10.1093/jn/135.11.2694	PROPN
ecletica-1173	559	52	https://doi.org/10.1093/jn/135.11.2694	https://doi.org/10.1093/jn/135.11.2694	PROPN
ecletica-1173	559	53	https://doi.org/10.1093/jn/135.11.2694	https://doi.org/10.1093/jn/135.11.2694	PROPN
ecletica-1173	559	54	https://doi.org/10.1098/rspa.1929.0094	https://doi.org/10.1098/rspa.1929.0094	PROPN
ecletica-1173	560	1	https://doi.org/10.1098/rspa.1929.0094	https://doi.org/10.1098/rspa.1929.0094	PROPN
ecletica-1173	560	2	https://doi.org/10.1098/rspa.1929.0094	https://doi.org/10.1098/rspa.1929.0094	PROPN
ecletica-1173	560	3	https://doi.org/10.1038/309552a0	https://doi.org/10.1038/309552a0	PROPN
ecletica-1173	560	4	https://doi.org/10.1038/309552a0	https://doi.org/10.1038/309552a0	PROPN
ecletica-1173	560	5	https://doi.org/10.1038/309552a0	https://doi.org/10.1038/309552a0	PROPN
ecletica-1173	560	6	https://doi.org/10.1016/s1359-6446(03)02690-4	https://doi.org/10.1016/s1359-6446(03)02690-4	VERB
ecletica-1173	560	7	https://doi.org/10.1016/s1359-6446(03)02690-4	https://doi.org/10.1016/s1359-6446(03)02690-4	PRON
ecletica-1173	560	8	https://doi.org/10.1016/s1359-6446(03)02690-4	https://doi.org/10.1016/s1359-6446(03)02690-4	PROPN
ecletica-1173	560	9	https://doi.org/10.4161/19420862.2015.989042	https://doi.org/10.4161/19420862.2015.989042	PROPN
ecletica-1173	560	10	https://doi.org/10.4161/19420862.2015.989042	https://doi.org/10.4161/19420862.2015.989042	PROPN
ecletica-1173	560	11	https://doi.org/10.4161/19420862.2015.989042	https://doi.org/10.4161/19420862.2015.989042	PROPN
ecletica-1173	560	12	https://doi.org/10.1038/nrclinonc.2009.102	https://doi.org/10.1038/nrclinonc.2009.102	PRON
ecletica-1173	560	13	https://doi.org/10.1038/nrclinonc.2009.102	https://doi.org/10.1038/nrclinonc.2009.102	PROPN
ecletica-1173	560	14	https://doi.org/10.1038/nrclinonc.2009.102	https://doi.org/10.1038/nrclinonc.2009.102	PROPN
ecletica-1173	560	15	https://doi.org/10.1038/nrclinonc.2009.102	https://doi.org/10.1038/nrclinonc.2009.102	PROPN
ecletica-1173	560	16	https://doi.org/10.15406/jnhfe.2014.01.00031	https://doi.org/10.15406/jnhfe.2014.01.00031	X
ecletica-1173	560	17	https://doi.org/10.15406/jnhfe.2014.01.00031	https://doi.org/10.15406/jnhfe.2014.01.00031	X
ecletica-1173	560	18	https://doi.org/10.15406/jnhfe.2014.01.00031	https://doi.org/10.15406/jnhfe.2014.01.00031	X
ecletica-1173	560	19	https://doi.org/10.15406/jnhfe.2014.01.00031	https://doi.org/10.15406/jnhfe.2014.01.00031	X
ecletica-1173	560	20	https://doi.org/10.15406/jnhfe.2014.01.00031	https://doi.org/10.15406/jnhfe.2014.01.00031	X
ecletica-1173	560	21	https://doi.org/10.3945/an.114.006122	https://doi.org/10.3945/an.114.006122	X
ecletica-1173	560	22	https://doi.org/10.3945/an.114.006122	https://doi.org/10.3945/an.114.006122	PROPN
ecletica-1173	560	23	https://doi.org/10.3945/an.114.006122	https://doi.org/10.3945/an.114.006122	PROPN
ecletica-1173	560	24	https://doi.org/10.3945/an.114.006122	https://doi.org/10.3945/an.114.006122	PROPN
ecletica-1173	560	25	https://doi.org/10.3945/an.114.006122	https://doi.org/10.3945/an.114.006122	PROPN
ecletica-1173	560	26	https://doi.org/10.1634/theoncologist.2007-0090	https://doi.org/10.1634/theoncologist.2007-0090	NOUN
ecletica-1173	560	27	https://doi.org/10.1634/theoncologist.2007-0090	https://doi.org/10.1634/theoncologist.2007-0090	NOUN
ecletica-1173	560	28	https://doi.org/10.1634/theoncologist.2007-0090	https://doi.org/10.1634/theoncologist.2007-0090	NOUN
ecletica-1173	560	29	https://doi.org/10.1038/nrd1064	https://doi.org/10.1038/nrd1064	PROPN
ecletica-1173	560	30	https://doi.org/10.1038/nrd1064	https://doi.org/10.1038/nrd1064	NUM
ecletica-1173	560	31	https://doi.org/10.1038/nrd1064	https://doi.org/10.1038/nrd1064	PROPN
ecletica-1173	560	32	https://doi.org/10.1038/nrd1309	https://doi.org/10.1038/nrd1309	PROPN
ecletica-1173	560	33	https://doi.org/10.1038/nrd1309	https://doi.org/10.1038/nrd1309	NOUN
ecletica-1173	560	34	https://doi.org/10.1038/nrd1309	https://doi.org/10.1038/nrd1309	NOUN
ecletica-1173	560	35	https://doi.org/10.1016/j.sbi.2004.01.005	https://doi.org/10.1016/j.sbi.2004.01.005	VERB
ecletica-1173	560	36	https://doi.org/10.1016/j.sbi.2004.01.005	https://doi.org/10.1016/j.sbi.2004.01.005	VERB
ecletica-1173	560	37	https://doi.org/10.1016/j.sbi.2004.01.005	https://doi.org/10.1016/j.sbi.2004.01.005	VERB
ecletica-1173	560	38	https://doi.org/10.1016/j.sbi.2004.01.005	https://doi.org/10.1016/j.sbi.2004.01.005	VERB
ecletica-1173	560	39	https://doi.org/10.1098/rstb.1998.0250	https://doi.org/10.1098/rstb.1998.0250	PROPN
ecletica-1173	560	40	https://doi.org/10.1098/rstb.1998.0250	https://doi.org/10.1098/rstb.1998.0250	PROPN
ecletica-1173	560	41	review	review	NOUN
ecletica-1173	560	42	article	article	NOUN
ecletica-1173	560	43	iq.unesp.br/ecletica	iq.unesp.br/ecletica	PROPN
ecletica-1173	560	44	30	30	NUM
ecletica-1173	560	45	eclética	eclética	PROPN
ecletica-1173	560	46	química	química	PROPN
ecletica-1173	560	47	journal	journal	PROPN
ecletica-1173	560	48	,	,	PUNCT
ecletica-1173	560	49	vol	vol	NOUN
ecletica-1173	560	50	.	.	PROPN
ecletica-1173	560	51	46	46	NUM
ecletica-1173	560	52	,	,	PUNCT
ecletica-1173	560	53	n.	n.	NOUN
ecletica-1173	560	54	3	3	NUM
ecletica-1173	560	55	,	,	PUNCT
ecletica-1173	560	56	2021	2021	NUM
ecletica-1173	560	57	,	,	PUNCT
ecletica-1173	560	58	17	17	NUM
ecletica-1173	560	59	-	-	SYM
ecletica-1173	560	60	32	32	NUM
ecletica-1173	560	61	issn	issn	NOUN
ecletica-1173	560	62	:	:	PUNCT
ecletica-1173	560	63	1678	1678	NUM
ecletica-1173	560	64	-	-	SYM
ecletica-1173	560	65	4618	4618	NUM
ecletica-1173	560	66	doi	doi	NOUN
ecletica-1173	560	67	:	:	PUNCT
ecletica-1173	560	68	10.26850/1678	10.26850/1678	NUM
ecletica-1173	560	69	-	-	SYM
ecletica-1173	560	70	4618eqj.v46.3.2021.p17	4618eqj.v46.3.2021.p17	NOUN
ecletica-1173	560	71	-	-	PUNCT
ecletica-1173	560	72	32	32	NUM
ecletica-1173	560	73	soc	soc	NOUN
ecletica-1173	560	74	.	.	PUNCT
ecletica-1173	561	1	lond	lond	PROPN
ecletica-1173	561	2	.	.	PUNCT
ecletica-1173	562	1	b	b	X
ecletica-1173	562	2	1998	1998	NUM
ecletica-1173	562	3	,	,	PUNCT
ecletica-1173	562	4	353	353	NUM
ecletica-1173	562	5	(	(	PUNCT
ecletica-1173	562	6	1370	1370	NUM
ecletica-1173	562	7	)	)	PUNCT
ecletica-1173	562	8	,	,	PUNCT
ecletica-1173	562	9	857–870	857–870	NUM
ecletica-1173	562	10	.	.	PUNCT
ecletica-1173	563	1	https://doi.org/10.1098/rstb.1998.0250	https://doi.org/10.1098/rstb.1998.0250	PROPN
ecletica-1173	563	2	.	.	PUNCT
ecletica-1173	564	1	hanahan	hanahan	PROPN
ecletica-1173	564	2	,	,	PUNCT
ecletica-1173	564	3	d.	d.	PROPN
ecletica-1173	564	4	;	;	PUNCT
ecletica-1173	564	5	weinberg	weinberg	PROPN
ecletica-1173	564	6	,	,	PUNCT
ecletica-1173	564	7	r.	r.	PROPN
ecletica-1173	564	8	a.	a.	PROPN
ecletica-1173	565	1	the	the	DET
ecletica-1173	565	2	hallmarks	hallmark	NOUN
ecletica-1173	565	3	of	of	ADP
ecletica-1173	565	4	cancer	cancer	NOUN
ecletica-1173	565	5	.	.	PUNCT
ecletica-1173	566	1	cell	cell	NOUN
ecletica-1173	566	2	2000	2000	NUM
ecletica-1173	566	3	,	,	PUNCT
ecletica-1173	566	4	100	100	NUM
ecletica-1173	566	5	(	(	PUNCT
ecletica-1173	566	6	1	1	NUM
ecletica-1173	566	7	)	)	PUNCT
ecletica-1173	566	8	,	,	PUNCT
ecletica-1173	566	9	57–70	57–70	NUM
ecletica-1173	566	10	.	.	PUNCT
ecletica-1173	567	1	https://doi.org/10.1016/s00928674(00)81683-9	https://doi.org/10.1016/s00928674(00)81683-9	NOUN
ecletica-1173	567	2	.	.	PUNCT
ecletica-1173	568	1	hartree	hartree	PROPN
ecletica-1173	568	2	,	,	PUNCT
ecletica-1173	568	3	d.	d.	PROPN
ecletica-1173	568	4	r.	r.	PROPN
ecletica-1173	568	5	the	the	DET
ecletica-1173	568	6	wave	wave	NOUN
ecletica-1173	568	7	mechanics	mechanic	NOUN
ecletica-1173	568	8	of	of	ADP
ecletica-1173	568	9	an	an	DET
ecletica-1173	568	10	atom	atom	NOUN
ecletica-1173	568	11	with	with	ADP
ecletica-1173	568	12	a	a	DET
ecletica-1173	568	13	noncoulomb	noncoulomb	NOUN
ecletica-1173	568	14	central	central	ADJ
ecletica-1173	568	15	field	field	NOUN
ecletica-1173	568	16	.	.	PUNCT
ecletica-1173	569	1	part	part	PROPN
ecletica-1173	569	2	ii	ii	PROPN
ecletica-1173	569	3	.	.	PUNCT
ecletica-1173	570	1	some	some	DET
ecletica-1173	570	2	results	result	NOUN
ecletica-1173	570	3	and	and	CCONJ
ecletica-1173	570	4	discussion	discussion	NOUN
ecletica-1173	570	5	.	.	PUNCT
ecletica-1173	571	1	math	math	NOUN
ecletica-1173	571	2	.	.	PUNCT
ecletica-1173	572	1	proc	proc	PROPN
ecletica-1173	572	2	.	.	PUNCT
ecletica-1173	573	1	camb	camb	PROPN
ecletica-1173	573	2	.	.	PUNCT
ecletica-1173	574	1	philos	philos	PROPN
ecletica-1173	574	2	.	.	PUNCT
ecletica-1173	575	1	soc	soc	PROPN
ecletica-1173	575	2	.	.	PUNCT
ecletica-1173	576	1	1928a	1928a	NUM
ecletica-1173	576	2	,	,	PUNCT
ecletica-1173	576	3	24	24	NUM
ecletica-1173	576	4	(	(	PUNCT
ecletica-1173	576	5	1	1	NUM
ecletica-1173	576	6	)	)	PUNCT
ecletica-1173	576	7	,	,	PUNCT
ecletica-1173	576	8	111–132	111–132	NUM
ecletica-1173	576	9	.	.	PUNCT
ecletica-1173	577	1	https://doi.org/10.1017/s0305004100011920	https://doi.org/10.1017/s0305004100011920	NUM
ecletica-1173	577	2	.	.	PUNCT
ecletica-1173	577	3	hartree	hartree	PROPN
ecletica-1173	577	4	,	,	PUNCT
ecletica-1173	577	5	d.	d.	PROPN
ecletica-1173	577	6	r.	r.	PROPN
ecletica-1173	577	7	the	the	DET
ecletica-1173	577	8	wave	wave	NOUN
ecletica-1173	577	9	mechanics	mechanic	NOUN
ecletica-1173	577	10	of	of	ADP
ecletica-1173	577	11	an	an	DET
ecletica-1173	577	12	atom	atom	NOUN
ecletica-1173	577	13	with	with	ADP
ecletica-1173	577	14	a	a	DET
ecletica-1173	577	15	noncoulomb	noncoulomb	NOUN
ecletica-1173	577	16	central	central	ADJ
ecletica-1173	577	17	field	field	NOUN
ecletica-1173	577	18	.	.	PUNCT
ecletica-1173	578	1	part	part	NOUN
ecletica-1173	578	2	iii	iii	PROPN
ecletica-1173	578	3	.	.	PROPN
ecletica-1173	578	4	term	term	NOUN
ecletica-1173	578	5	values	value	NOUN
ecletica-1173	578	6	and	and	CCONJ
ecletica-1173	578	7	intensities	intensity	NOUN
ecletica-1173	578	8	in	in	ADP
ecletica-1173	578	9	series	series	NOUN
ecletica-1173	578	10	in	in	ADP
ecletica-1173	578	11	optical	optical	ADJ
ecletica-1173	578	12	spectra	spectra	PROPN
ecletica-1173	578	13	.	.	PROPN
ecletica-1173	578	14	math	math	PROPN
ecletica-1173	578	15	.	.	PUNCT
ecletica-1173	579	1	proc	proc	PROPN
ecletica-1173	579	2	.	.	PUNCT
ecletica-1173	580	1	camb	camb	PROPN
ecletica-1173	580	2	.	.	PUNCT
ecletica-1173	581	1	philos	philos	PROPN
ecletica-1173	581	2	.	.	PUNCT
ecletica-1173	582	1	soc	soc	PROPN
ecletica-1173	582	2	.	.	PUNCT
ecletica-1173	583	1	1928b	1928b	PROPN
ecletica-1173	583	2	,	,	PUNCT
ecletica-1173	583	3	24	24	NUM
ecletica-1173	583	4	(	(	PUNCT
ecletica-1173	583	5	3	3	NUM
ecletica-1173	583	6	)	)	PUNCT
ecletica-1173	583	7	,	,	PUNCT
ecletica-1173	583	8	426–437	426–437	NUM
ecletica-1173	583	9	.	.	PUNCT
ecletica-1173	584	1	https://doi.org/10.1017/s0305004100015954	https://doi.org/10.1017/s0305004100015954	NUM
ecletica-1173	584	2	.	.	PUNCT
ecletica-1173	585	1	horrobin	horrobin	PROPN
ecletica-1173	585	2	,	,	PUNCT
ecletica-1173	585	3	d.	d.	PROPN
ecletica-1173	585	4	f.	f.	PROPN
ecletica-1173	585	5	realism	realism	PROPN
ecletica-1173	585	6	in	in	ADP
ecletica-1173	585	7	drug	drug	NOUN
ecletica-1173	585	8	discovery	discovery	NOUN
ecletica-1173	585	9	–	–	PUNCT
ecletica-1173	585	10	could	could	AUX
ecletica-1173	585	11	cassandra	cassandra	NOUN
ecletica-1173	585	12	be	be	AUX
ecletica-1173	585	13	right	right	ADJ
ecletica-1173	585	14	?	?	PUNCT
ecletica-1173	586	1	nat	nat	NOUN
ecletica-1173	586	2	.	.	PUNCT
ecletica-1173	587	1	biotechnol	biotechnol	PROPN
ecletica-1173	587	2	.	.	PUNCT
ecletica-1173	588	1	2001	2001	NUM
ecletica-1173	588	2	,	,	PUNCT
ecletica-1173	588	3	19	19	NUM
ecletica-1173	588	4	,	,	PUNCT
ecletica-1173	588	5	1099–1100	1099–1100	NUM
ecletica-1173	588	6	.	.	PUNCT
ecletica-1173	589	1	https://doi.org/10.1038/nbt1201-1099	https://doi.org/10.1038/nbt1201-1099	X
ecletica-1173	589	2	.	.	PUNCT
ecletica-1173	590	1	james	james	PROPN
ecletica-1173	590	2	,	,	PUNCT
ecletica-1173	590	3	l.	l.	PROPN
ecletica-1173	590	4	c.	c.	PROPN
ecletica-1173	590	5	;	;	PUNCT
ecletica-1173	590	6	roversi	roversi	NOUN
ecletica-1173	590	7	,	,	PUNCT
ecletica-1173	590	8	p.	p.	NOUN
ecletica-1173	590	9	;	;	PUNCT
ecletica-1173	591	1	tawfik	tawfik	ADV
ecletica-1173	591	2	,	,	PUNCT
ecletica-1173	591	3	d.	d.	PROPN
ecletica-1173	591	4	s.	s.	PROPN
ecletica-1173	591	5	antibody	antibody	PROPN
ecletica-1173	591	6	multispecificity	multispecificity	NOUN
ecletica-1173	591	7	mediated	mediate	VERB
ecletica-1173	591	8	by	by	ADP
ecletica-1173	591	9	conformational	conformational	ADJ
ecletica-1173	591	10	diversity	diversity	NOUN
ecletica-1173	591	11	.	.	PUNCT
ecletica-1173	592	1	science	science	NOUN
ecletica-1173	592	2	2003	2003	NUM
ecletica-1173	592	3	,	,	PUNCT
ecletica-1173	592	4	299	299	NUM
ecletica-1173	592	5	(	(	PUNCT
ecletica-1173	592	6	5611	5611	NUM
ecletica-1173	592	7	)	)	PUNCT
ecletica-1173	592	8	,	,	PUNCT
ecletica-1173	592	9	1362–1367	1362–1367	NUM
ecletica-1173	592	10	.	.	PUNCT
ecletica-1173	593	1	https://doi.org/10.1126/science.1079731	https://doi.org/10.1126/science.1079731	PROPN
ecletica-1173	593	2	.	.	PUNCT
ecletica-1173	594	1	jemal	jemal	ADJ
ecletica-1173	594	2	,	,	PUNCT
ecletica-1173	594	3	a.	a.	NOUN
ecletica-1173	594	4	;	;	PUNCT
ecletica-1173	594	5	ward	ward	PROPN
ecletica-1173	594	6	,	,	PUNCT
ecletica-1173	594	7	e.	e.	PROPN
ecletica-1173	594	8	;	;	PUNCT
ecletica-1173	594	9	thun	thun	PROPN
ecletica-1173	594	10	,	,	PUNCT
ecletica-1173	594	11	m.	m.	NOUN
ecletica-1173	594	12	declining	decline	VERB
ecletica-1173	594	13	death	death	NOUN
ecletica-1173	594	14	rates	rate	NOUN
ecletica-1173	594	15	reflect	reflect	VERB
ecletica-1173	594	16	progress	progress	NOUN
ecletica-1173	594	17	against	against	ADP
ecletica-1173	594	18	cancer	cancer	NOUN
ecletica-1173	594	19	.	.	PUNCT
ecletica-1173	595	1	plos	plos	PROPN
ecletica-1173	595	2	one	one	NUM
ecletica-1173	595	3	2010	2010	NUM
ecletica-1173	595	4	,	,	PUNCT
ecletica-1173	595	5	5	5	NUM
ecletica-1173	595	6	(	(	PUNCT
ecletica-1173	595	7	3	3	NUM
ecletica-1173	595	8	)	)	PUNCT
ecletica-1173	595	9	,	,	PUNCT
ecletica-1173	595	10	e9584	e9584	PROPN
ecletica-1173	595	11	.	.	PUNCT
ecletica-1173	596	1	https://doi.org/10.1371/journal.pone.0009584	https://doi.org/10.1371/journal.pone.0009584	PROPN
ecletica-1173	596	2	.	.	PUNCT
ecletica-1173	597	1	jia	jia	PROPN
ecletica-1173	597	2	,	,	PUNCT
ecletica-1173	597	3	j.	j.	PROPN
ecletica-1173	597	4	;	;	PUNCT
ecletica-1173	597	5	zhu	zhu	PROPN
ecletica-1173	597	6	,	,	PUNCT
ecletica-1173	597	7	f.	f.	PROPN
ecletica-1173	597	8	;	;	PUNCT
ecletica-1173	597	9	ma	ma	PROPN
ecletica-1173	597	10	,	,	PUNCT
ecletica-1173	597	11	x.	x.	PROPN
ecletica-1173	597	12	;	;	PUNCT
ecletica-1173	597	13	cao	cao	PROPN
ecletica-1173	597	14	,	,	PUNCT
ecletica-1173	597	15	z.	z.	PROPN
ecletica-1173	597	16	,	,	PUNCT
ecletica-1173	597	17	cao	cao	PROPN
ecletica-1173	597	18	,	,	PUNCT
ecletica-1173	597	19	z.	z.	PROPN
ecletica-1173	597	20	w.	w.	PROPN
ecletica-1173	597	21	;	;	PUNCT
ecletica-1173	597	22	li	li	PROPN
ecletica-1173	597	23	,	,	PUNCT
ecletica-1173	597	24	y.	y.	PROPN
ecletica-1173	597	25	x.	x.	PROPN
ecletica-1173	597	26	;	;	PUNCT
ecletica-1173	597	27	yu	yu	PROPN
ecletica-1173	597	28	,	,	PUNCT
ecletica-1173	597	29	z.	z.	PROPN
ecletica-1173	597	30	c.	c.	PROPN
ecletica-1173	597	31	mechanisms	mechanism	NOUN
ecletica-1173	597	32	of	of	ADP
ecletica-1173	597	33	drug	drug	NOUN
ecletica-1173	597	34	combinations	combination	NOUN
ecletica-1173	597	35	:	:	PUNCT
ecletica-1173	597	36	interaction	interaction	NOUN
ecletica-1173	597	37	and	and	CCONJ
ecletica-1173	597	38	network	network	NOUN
ecletica-1173	597	39	perspectives	perspective	NOUN
ecletica-1173	597	40	.	.	PUNCT
ecletica-1173	598	1	nat	nat	PROPN
ecletica-1173	598	2	.	.	PUNCT
ecletica-1173	599	1	rev	rev	PROPN
ecletica-1173	599	2	.	.	PROPN
ecletica-1173	599	3	drug	drug	NOUN
ecletica-1173	599	4	discov	discov	NOUN
ecletica-1173	599	5	.	.	PUNCT
ecletica-1173	600	1	2009	2009	NUM
ecletica-1173	600	2	,	,	PUNCT
ecletica-1173	600	3	8	8	NUM
ecletica-1173	600	4	,	,	PUNCT
ecletica-1173	600	5	111	111	NUM
ecletica-1173	600	6	–	–	PUNCT
ecletica-1173	600	7	128	128	NUM
ecletica-1173	600	8	.	.	PUNCT
ecletica-1173	600	9	https://doi.org/10.1038/nrd2683	https://doi.org/10.1038/nrd2683	NOUN
ecletica-1173	600	10	.	.	PUNCT
ecletica-1173	601	1	johnson	johnson	PROPN
ecletica-1173	601	2	,	,	PUNCT
ecletica-1173	601	3	m.	m.	NOUN
ecletica-1173	601	4	antibody	antibody	NOUN
ecletica-1173	601	5	structure	structure	NOUN
ecletica-1173	601	6	and	and	CCONJ
ecletica-1173	601	7	antibody	antibody	NOUN
ecletica-1173	601	8	fragments	fragment	NOUN
ecletica-1173	601	9	.	.	PUNCT
ecletica-1173	602	1	mater	mater	NOUN
ecletica-1173	602	2	.	.	PUNCT
ecletica-1173	603	1	methods	method	NOUN
ecletica-1173	603	2	2013	2013	NUM
ecletica-1173	603	3	,	,	PUNCT
ecletica-1173	603	4	3	3	NUM
ecletica-1173	603	5	,	,	PUNCT
ecletica-1173	603	6	160	160	NUM
ecletica-1173	603	7	.	.	PUNCT
ecletica-1173	603	8	https://doi.org/10.13070/mm.en.3.160	https://doi.org/10.13070/mm.en.3.160	PROPN
ecletica-1173	603	9	.	.	PUNCT
ecletica-1173	604	1	jordan	jordan	PROPN
ecletica-1173	604	2	,	,	PUNCT
ecletica-1173	604	3	p.	p.	PROPN
ecletica-1173	604	4	;	;	PUNCT
ecletica-1173	604	5	fock	fock	ADJ
ecletica-1173	604	6	,	,	PUNCT
ecletica-1173	604	7	v.	v.	ADP
ecletica-1173	604	8	neue	neue	PROPN
ecletica-1173	604	9	unbestimmtheit	unbestimmtheit	PROPN
ecletica-1173	604	10	eigenschaften	eigenschaften	PROPN
ecletica-1173	604	11	des	des	PROPN
ecletica-1173	604	12	elektromagnetischen	elektromagnetischen	PROPN
ecletica-1173	604	13	feldes	felde	NOUN
ecletica-1173	604	14	.	.	PUNCT
ecletica-1173	605	1	z.	z.	PROPN
ecletica-1173	605	2	physik	physik	PROPN
ecletica-1173	605	3	1930	1930	NUM
ecletica-1173	605	4	,	,	PUNCT
ecletica-1173	605	5	66	66	NUM
ecletica-1173	605	6	,	,	PUNCT
ecletica-1173	605	7	206–209	206–209	NUM
ecletica-1173	605	8	.	.	PUNCT
ecletica-1173	606	1	https://doi.org/10.1007/bf01392901	https://doi.org/10.1007/bf01392901	NOUN
ecletica-1173	606	2	.	.	PUNCT
ecletica-1173	607	1	keiser	keiser	PROPN
ecletica-1173	607	2	,	,	PUNCT
ecletica-1173	607	3	m.	m.	PROPN
ecletica-1173	607	4	j.	j.	PROPN
ecletica-1173	607	5	;	;	PUNCT
ecletica-1173	607	6	setola	setola	PROPN
ecletica-1173	607	7	,	,	PUNCT
ecletica-1173	607	8	v.	v.	PROPN
ecletica-1173	607	9	;	;	PUNCT
ecletica-1173	607	10	irwin	irwin	PROPN
ecletica-1173	607	11	,	,	PUNCT
ecletica-1173	607	12	j.	j.	PROPN
ecletica-1173	607	13	j.	j.	PROPN
ecletica-1173	607	14	;	;	PUNCT
ecletica-1173	607	15	laggner	laggner	PROPN
ecletica-1173	607	16	,	,	PUNCT
ecletica-1173	607	17	c.	c.	PROPN
ecletica-1173	607	18	;	;	PUNCT
ecletica-1173	607	19	abbas	abbas	PROPN
ecletica-1173	607	20	,	,	PUNCT
ecletica-1173	607	21	a.	a.	NOUN
ecletica-1173	607	22	i.	i.	PROPN
ecletica-1173	607	23	;	;	PUNCT
ecletica-1173	607	24	hufeisen	hufeisen	PROPN
ecletica-1173	607	25	,	,	PUNCT
ecletica-1173	607	26	s.	s.	PROPN
ecletica-1173	607	27	j.	j.	PROPN
ecletica-1173	607	28	;	;	PUNCT
ecletica-1173	607	29	jensen	jensen	PROPN
ecletica-1173	607	30	,	,	PUNCT
ecletica-1173	607	31	h.	h.	PROPN
ecletica-1173	607	32	n.	n.	PROPN
ecletica-1173	607	33	;	;	PUNCT
ecletica-1173	607	34	kuijer	kuijer	PROPN
ecletica-1173	607	35	,	,	PUNCT
ecletica-1173	607	36	m.	m.	PROPN
ecletica-1173	607	37	b.	b.	PROPN
ecletica-1173	607	38	;	;	PUNCT
ecletica-1173	607	39	matos	matos	PROPN
ecletica-1173	607	40	,	,	PUNCT
ecletica-1173	607	41	r.	r.	PROPN
ecletica-1173	607	42	c.	c.	PROPN
ecletica-1173	607	43	;	;	PUNCT
ecletica-1173	607	44	tran	tran	PROPN
ecletica-1173	607	45	,	,	PUNCT
ecletica-1173	607	46	t.	t.	PROPN
ecletica-1173	607	47	b.	b.	PROPN
ecletica-1173	607	48	;	;	PUNCT
ecletica-1173	607	49	whaley	whaley	PROPN
ecletica-1173	607	50	,	,	PUNCT
ecletica-1173	607	51	glennon	glennon	PROPN
ecletica-1173	607	52	,	,	PUNCT
ecletica-1173	607	53	r.	r.	PROPN
ecletica-1173	607	54	a.	a.	PROPN
ecletica-1173	607	55	;	;	PUNCT
ecletica-1173	607	56	hert	hert	PROPN
ecletica-1173	607	57	,	,	PUNCT
ecletica-1173	607	58	j.	j.	PROPN
ecletica-1173	607	59	;	;	PUNCT
ecletica-1173	607	60	thomas	thomas	PROPN
ecletica-1173	607	61	,	,	PUNCT
ecletica-1173	607	62	k.	k.	PROPN
ecletica-1173	607	63	l.	l.	PROPN
ecletica-1173	607	64	h.	h.	PROPN
ecletica-1173	607	65	;	;	PUNCT
ecletica-1173	607	66	edwards	edwards	PROPN
ecletica-1173	607	67	,	,	PUNCT
ecletica-1173	607	68	d.	d.	PROPN
ecletica-1173	607	69	d.	d.	PROPN
ecletica-1173	607	70	;	;	PUNCT
ecletica-1173	607	71	shoichet	shoichet	PROPN
ecletica-1173	607	72	,	,	PUNCT
ecletica-1173	607	73	b.	b.	PROPN
ecletica-1173	607	74	k.	k.	PROPN
ecletica-1173	607	75	;	;	PUNCT
ecletica-1173	607	76	roth	roth	PROPN
ecletica-1173	607	77	,	,	PUNCT
ecletica-1173	607	78	b.	b.	PROPN
ecletica-1173	607	79	l.	l.	PROPN
ecletica-1173	607	80	predicting	predict	VERB
ecletica-1173	607	81	new	new	ADJ
ecletica-1173	607	82	molecular	molecular	ADJ
ecletica-1173	607	83	targets	target	NOUN
ecletica-1173	607	84	for	for	ADP
ecletica-1173	607	85	known	know	VERB
ecletica-1173	607	86	drugs	drug	NOUN
ecletica-1173	607	87	.	.	PUNCT
ecletica-1173	608	1	nature	nature	NOUN
ecletica-1173	608	2	2009	2009	NUM
ecletica-1173	608	3	,	,	PUNCT
ecletica-1173	608	4	462	462	NUM
ecletica-1173	608	5	,	,	PUNCT
ecletica-1173	608	6	175–181	175–181	NUM
ecletica-1173	608	7	.	.	PUNCT
ecletica-1173	608	8	https://doi.org/10.1038/nature08506	https://doi.org/10.1038/nature08506	NOUN
ecletica-1173	608	9	.	.	PUNCT
ecletica-1173	609	1	koshland	koshland	PROPN
ecletica-1173	609	2	,	,	PUNCT
ecletica-1173	609	3	d.	d.	PROPN
ecletica-1173	609	4	e.	e.	PROPN
ecletica-1173	609	5	application	application	PROPN
ecletica-1173	609	6	of	of	ADP
ecletica-1173	609	7	a	a	DET
ecletica-1173	609	8	theory	theory	NOUN
ecletica-1173	609	9	of	of	ADP
ecletica-1173	609	10	enzyme	enzyme	NOUN
ecletica-1173	609	11	specificity	specificity	NOUN
ecletica-1173	609	12	to	to	ADP
ecletica-1173	609	13	protein	protein	NOUN
ecletica-1173	609	14	synthesis	synthesis	NOUN
ecletica-1173	609	15	.	.	PUNCT
ecletica-1173	610	1	proc	proc	PROPN
ecletica-1173	610	2	natl	natl	PROPN
ecletica-1173	610	3	acad	acad	PROPN
ecletica-1173	610	4	sci	sci	PROPN
ecletica-1173	610	5	1958	1958	NUM
ecletica-1173	610	6	,	,	PUNCT
ecletica-1173	610	7	44(2	44(2	NOUN
ecletica-1173	610	8	)	)	PUNCT
ecletica-1173	610	9	,	,	PUNCT
ecletica-1173	610	10	98–104	98–104	PROPN
ecletica-1173	610	11	.	.	PUNCT
ecletica-1173	610	12	https://doi.org/10.1073/pnas.44.2.98	https://doi.org/10.1073/pnas.44.2.98	PROPN
ecletica-1173	610	13	.	.	PUNCT
ecletica-1173	611	1	krakauer	krakauer	PROPN
ecletica-1173	611	2	,	,	PUNCT
ecletica-1173	611	3	j.	j.	PROPN
ecletica-1173	611	4	w.	w.	PROPN
ecletica-1173	611	5	;	;	PUNCT
ecletica-1173	611	6	ghazanfar	ghazanfar	ADV
ecletica-1173	611	7	,	,	PUNCT
ecletica-1173	611	8	a.	a.	NOUN
ecletica-1173	611	9	a.	a.	NOUN
ecletica-1173	611	10	;	;	PUNCT
ecletica-1173	611	11	gomez	gomez	NOUN
ecletica-1173	611	12	-	-	PUNCT
ecletica-1173	611	13	marin	marin	PROPN
ecletica-1173	611	14	,	,	PUNCT
ecletica-1173	611	15	a.	a.	NOUN
ecletica-1173	611	16	;	;	PUNCT
ecletica-1173	611	17	maclver	maclver	NOUN
ecletica-1173	611	18	,	,	PUNCT
ecletica-1173	611	19	m.	m.	NOUN
ecletica-1173	611	20	a.	a.	PROPN
ecletica-1173	611	21	;	;	PUNCT
ecletica-1173	611	22	poeppel	poeppel	PROPN
ecletica-1173	611	23	,	,	PUNCT
ecletica-1173	611	24	d.	d.	PROPN
ecletica-1173	611	25	neuroscience	neuroscience	PROPN
ecletica-1173	611	26	needs	need	VERB
ecletica-1173	611	27	behavior	behavior	NOUN
ecletica-1173	611	28	:	:	PUNCT
ecletica-1173	611	29	correcting	correct	VERB
ecletica-1173	611	30	a	a	DET
ecletica-1173	611	31	reductionist	reductionist	ADJ
ecletica-1173	611	32	bias	bias	NOUN
ecletica-1173	611	33	.	.	PUNCT
ecletica-1173	612	1	neuron	neuron	PROPN
ecletica-1173	612	2	2017	2017	NUM
ecletica-1173	612	3	,	,	PUNCT
ecletica-1173	612	4	93	93	NUM
ecletica-1173	612	5	(	(	PUNCT
ecletica-1173	612	6	3	3	NUM
ecletica-1173	612	7	)	)	PUNCT
ecletica-1173	612	8	,	,	PUNCT
ecletica-1173	612	9	480	480	NUM
ecletica-1173	612	10	–	–	PUNCT
ecletica-1173	612	11	490	490	NUM
ecletica-1173	612	12	.	.	PUNCT
ecletica-1173	612	13	https://doi.org/10.1016/j.neuron.2016.12.041	https://doi.org/10.1016/j.neuron.2016.12.041	PROPN
ecletica-1173	612	14	.	.	PROPN
ecletica-1173	612	15	kubinyi	kubinyi	PROPN
ecletica-1173	612	16	,	,	PUNCT
ecletica-1173	612	17	h.	h.	PROPN
ecletica-1173	612	18	drug	drug	PROPN
ecletica-1173	612	19	research	research	PROPN
ecletica-1173	612	20	:	:	PUNCT
ecletica-1173	612	21	myths	myth	NOUN
ecletica-1173	612	22	,	,	PUNCT
ecletica-1173	612	23	hype	hype	NOUN
ecletica-1173	612	24	and	and	CCONJ
ecletica-1173	612	25	reality	reality	NOUN
ecletica-1173	612	26	.	.	PUNCT
ecletica-1173	613	1	nat	nat	PROPN
ecletica-1173	613	2	.	.	PUNCT
ecletica-1173	614	1	rev	rev	PROPN
ecletica-1173	614	2	.	.	PROPN
ecletica-1173	614	3	drug	drug	NOUN
ecletica-1173	614	4	discov	discov	NOUN
ecletica-1173	614	5	.	.	PUNCT
ecletica-1173	615	1	2003	2003	NUM
ecletica-1173	615	2	,	,	PUNCT
ecletica-1173	615	3	2	2	NUM
ecletica-1173	615	4	,	,	PUNCT
ecletica-1173	615	5	665–668	665–668	NUM
ecletica-1173	615	6	.	.	PUNCT
ecletica-1173	616	1	https://doi.org/10.1038/nrd1156	https://doi.org/10.1038/nrd1156	PROPN
ecletica-1173	616	2	.	.	PUNCT
ecletica-1173	617	1	kümmel	kümmel	PROPN
ecletica-1173	617	2	,	,	PUNCT
ecletica-1173	617	3	h.	h.	PROPN
ecletica-1173	617	4	g.	g.	PROPN
ecletica-1173	617	5	a	a	DET
ecletica-1173	617	6	biography	biography	NOUN
ecletica-1173	617	7	of	of	ADP
ecletica-1173	617	8	the	the	DET
ecletica-1173	617	9	coupled	couple	VERB
ecletica-1173	617	10	cluster	cluster	NOUN
ecletica-1173	617	11	method	method	NOUN
ecletica-1173	617	12	.	.	PUNCT
ecletica-1173	618	1	in	in	ADP
ecletica-1173	618	2	:	:	PUNCT
ecletica-1173	618	3	recent	recent	ADJ
ecletica-1173	618	4	progress	progress	NOUN
ecletica-1173	618	5	in	in	ADP
ecletica-1173	618	6	many	many	ADJ
ecletica-1173	618	7	-	-	PUNCT
ecletica-1173	618	8	body	body	NOUN
ecletica-1173	618	9	theories	theory	NOUN
ecletica-1173	618	10	;	;	PUNCT
ecletica-1173	618	11	world	world	NOUN
ecletica-1173	618	12	scientific	scientific	NOUN
ecletica-1173	618	13	,	,	PUNCT
ecletica-1173	618	14	2002	2002	NUM
ecletica-1173	618	15	;	;	PUNCT
ecletica-1173	618	16	pp	pp	PROPN
ecletica-1173	618	17	334–348	334–348	NUM
ecletica-1173	618	18	.	.	PUNCT
ecletica-1173	619	1	https://doi.org/10.1142/9789812777843_0040	https://doi.org/10.1142/9789812777843_0040	ADJ
ecletica-1173	619	2	.	.	PUNCT
ecletica-1173	619	3	leach	leach	NOUN
ecletica-1173	619	4	,	,	PUNCT
ecletica-1173	619	5	a.	a.	PROPN
ecletica-1173	619	6	r.	r.	PROPN
ecletica-1173	619	7	molecular	molecular	PROPN
ecletica-1173	619	8	modelling	modelling	NOUN
ecletica-1173	619	9	:	:	PUNCT
ecletica-1173	619	10	principles	principle	NOUN
ecletica-1173	619	11	and	and	CCONJ
ecletica-1173	619	12	applications	application	NOUN
ecletica-1173	619	13	;	;	PUNCT
ecletica-1173	619	14	pearson	pearson	PROPN
ecletica-1173	619	15	education	education	PROPN
ecletica-1173	619	16	,	,	PUNCT
ecletica-1173	619	17	2001	2001	NUM
ecletica-1173	619	18	.	.	PUNCT
ecletica-1173	620	1	li	li	PROPN
ecletica-1173	620	2	,	,	PUNCT
ecletica-1173	620	3	p.	p.	PROPN
ecletica-1173	620	4	;	;	PUNCT
ecletica-1173	620	5	huang	huang	PROPN
ecletica-1173	620	6	,	,	PUNCT
ecletica-1173	620	7	c.	c.	PROPN
ecletica-1173	620	8	;	;	PUNCT
ecletica-1173	620	9	fu	fu	PROPN
ecletica-1173	620	10	,	,	PUNCT
ecletica-1173	620	11	y.	y.	PROPN
ecletica-1173	620	12	;	;	PUNCT
ecletica-1173	620	13	wang	wang	PROPN
ecletica-1173	620	14	,	,	PUNCT
ecletica-1173	620	15	j.	j.	PROPN
ecletica-1173	620	16	;	;	PUNCT
ecletica-1173	620	17	wu	wu	PROPN
ecletica-1173	620	18	,	,	PUNCT
ecletica-1173	620	19	z.	z.	PROPN
ecletica-1173	620	20	;	;	PUNCT
ecletica-1173	620	21	ru	ru	PROPN
ecletica-1173	620	22	,	,	PUNCT
ecletica-1173	620	23	j.	j.	PROPN
ecletica-1173	620	24	;	;	PUNCT
ecletica-1173	620	25	zheng	zheng	PROPN
ecletica-1173	620	26	,	,	PUNCT
ecletica-1173	620	27	c.	c.	PROPN
ecletica-1173	620	28	;	;	PUNCT
ecletica-1173	620	29	guo	guo	PROPN
ecletica-1173	620	30	,	,	PUNCT
ecletica-1173	620	31	z.	z.	PROPN
ecletica-1173	620	32	;	;	PUNCT
ecletica-1173	620	33	chen	chen	PROPN
ecletica-1173	620	34	,	,	PUNCT
ecletica-1173	620	35	x.	x.	PROPN
ecletica-1173	620	36	;	;	PUNCT
ecletica-1173	620	37	zhou	zhou	PROPN
ecletica-1173	620	38	,	,	PUNCT
ecletica-1173	620	39	w.	w.	PROPN
ecletica-1173	620	40	;	;	PUNCT
ecletica-1173	620	41	zhang	zhang	PROPN
ecletica-1173	620	42	,	,	PUNCT
ecletica-1173	620	43	w.	w.	PROPN
ecletica-1173	620	44	;	;	PUNCT
ecletica-1173	620	45	li	li	PROPN
ecletica-1173	620	46	,	,	PUNCT
ecletica-1173	620	47	y.	y.	PROPN
ecletica-1173	620	48	;	;	PUNCT
ecletica-1173	620	49	chen	chen	PROPN
ecletica-1173	620	50	,	,	PUNCT
ecletica-1173	620	51	j.	j.	PROPN
ecletica-1173	620	52	;	;	PUNCT
ecletica-1173	620	53	lu	lu	PROPN
ecletica-1173	620	54	,	,	PUNCT
ecletica-1173	620	55	a.	a.	PROPN
ecletica-1173	620	56	;	;	PUNCT
ecletica-1173	620	57	wang	wang	PROPN
ecletica-1173	620	58	,	,	PUNCT
ecletica-1173	620	59	y.	y.	PROPN
ecletica-1173	620	60	large	large	ADJ
ecletica-1173	620	61	-	-	PUNCT
ecletica-1173	620	62	scale	scale	NOUN
ecletica-1173	620	63	exploration	exploration	NOUN
ecletica-1173	620	64	and	and	CCONJ
ecletica-1173	620	65	analysis	analysis	NOUN
ecletica-1173	620	66	of	of	ADP
ecletica-1173	620	67	drug	drug	NOUN
ecletica-1173	620	68	combinations	combination	NOUN
ecletica-1173	620	69	.	.	PUNCT
ecletica-1173	621	1	bioinformatics	bioinformatic	NOUN
ecletica-1173	621	2	2015	2015	NUM
ecletica-1173	621	3	,	,	PUNCT
ecletica-1173	621	4	31	31	NUM
ecletica-1173	621	5	(	(	PUNCT
ecletica-1173	621	6	12	12	NUM
ecletica-1173	621	7	)	)	PUNCT
ecletica-1173	621	8	,	,	PUNCT
ecletica-1173	621	9	2007	2007	NUM
ecletica-1173	621	10	–	–	PUNCT
ecletica-1173	621	11	2016	2016	NUM
ecletica-1173	621	12	.	.	PUNCT
ecletica-1173	622	1	https://doi.org/10.1093/bioinformatics/btv080	https://doi.org/10.1093/bioinformatics/btv080	PROPN
ecletica-1173	622	2	.	.	PUNCT
ecletica-1173	623	1	li	li	PROPN
ecletica-1173	623	2	,	,	PUNCT
ecletica-1173	623	3	z.	z.	PROPN
ecletica-1173	623	4	;	;	PUNCT
ecletica-1173	623	5	han	han	PROPN
ecletica-1173	623	6	,	,	PUNCT
ecletica-1173	623	7	p.	p.	PROPN
ecletica-1173	623	8	;	;	PUNCT
ecletica-1173	623	9	you	you	PRON
ecletica-1173	623	10	,	,	PUNCT
ecletica-1173	623	11	z.-h	z.-h	PROPN
ecletica-1173	623	12	.	.	PUNCT
ecletica-1173	623	13	;	;	PUNCT
ecletica-1173	623	14	li	li	PROPN
ecletica-1173	623	15	,	,	PUNCT
ecletica-1173	623	16	x.	x.	PROPN
ecletica-1173	623	17	;	;	PUNCT
ecletica-1173	623	18	zhang	zhang	PROPN
ecletica-1173	623	19	,	,	PUNCT
ecletica-1173	623	20	y.	y.	PROPN
ecletica-1173	623	21	;	;	PUNCT
ecletica-1173	623	22	yu	yu	PROPN
ecletica-1173	623	23	,	,	PUNCT
ecletica-1173	623	24	h.	h.	PROPN
ecletica-1173	623	25	;	;	PUNCT
ecletica-1173	623	26	ru	ru	PROPN
ecletica-1173	623	27	,	,	PUNCT
ecletica-1173	623	28	n.	n.	PROPN
ecletica-1173	623	29	;	;	PUNCT
ecletica-1173	623	30	xing	xing	PROPN
ecletica-1173	623	31	,	,	PUNCT
ecletica-1173	623	32	c.	c.	PROPN
ecletica-1173	623	33	in	in	ADP
ecletica-1173	623	34	silico	silico	NOUN
ecletica-1173	623	35	prediction	prediction	NOUN
ecletica-1173	623	36	of	of	ADP
ecletica-1173	623	37	drug	drug	NOUN
ecletica-1173	623	38	-	-	PUNCT
ecletica-1173	623	39	target	target	NOUN
ecletica-1173	623	40	interaction	interaction	NOUN
ecletica-1173	623	41	networks	network	NOUN
ecletica-1173	623	42	based	base	VERB
ecletica-1173	623	43	on	on	ADP
ecletica-1173	623	44	drug	drug	NOUN
ecletica-1173	623	45	chemical	chemical	NOUN
ecletica-1173	623	46	structure	structure	NOUN
ecletica-1173	623	47	and	and	CCONJ
ecletica-1173	623	48	protein	protein	NOUN
ecletica-1173	623	49	sequences	sequence	NOUN
ecletica-1173	623	50	.	.	PUNCT
ecletica-1173	624	1	sci	sci	PROPN
ecletica-1173	624	2	.	.	PROPN
ecletica-1173	624	3	rep	rep	PROPN
ecletica-1173	624	4	.	.	PROPN
ecletica-1173	624	5	2017	2017	NUM
ecletica-1173	624	6	,	,	PUNCT
ecletica-1173	624	7	7	7	NUM
ecletica-1173	624	8	,	,	PUNCT
ecletica-1173	624	9	11174	11174	NUM
ecletica-1173	624	10	.	.	PUNCT
ecletica-1173	625	1	https://doi.org/10.1038/s41598-017-10724-0	https://doi.org/10.1038/s41598-017-10724-0	NUM
ecletica-1173	625	2	.	.	PUNCT
ecletica-1173	626	1	lok	lok	PROPN
ecletica-1173	626	2	,	,	PUNCT
ecletica-1173	626	3	c.	c.	PROPN
ecletica-1173	626	4	thinking	think	VERB
ecletica-1173	626	5	outside	outside	ADP
ecletica-1173	626	6	the	the	DET
ecletica-1173	626	7	cell	cell	NOUN
ecletica-1173	626	8	.	.	PUNCT
ecletica-1173	627	1	nat	nat	PROPN
ecletica-1173	627	2	biotechnol	biotechnol	NOUN
ecletica-1173	627	3	.	.	PUNCT
ecletica-1173	628	1	2006	2006	NUM
ecletica-1173	628	2	,	,	PUNCT
ecletica-1173	628	3	24	24	NUM
ecletica-1173	628	4	,	,	PUNCT
ecletica-1173	628	5	111–112	111–112	NUM
ecletica-1173	628	6	.	.	PUNCT
ecletica-1173	629	1	https://doi.org/10.1038/nbt0106-111	https://doi.org/10.1038/nbt0106-111	PROPN
ecletica-1173	629	2	.	.	PUNCT
ecletica-1173	629	3	lombardo	lombardo	PROPN
ecletica-1173	629	4	,	,	PUNCT
ecletica-1173	629	5	l.	l.	PROPN
ecletica-1173	629	6	j.	j.	PROPN
ecletica-1173	629	7	;	;	PUNCT
ecletica-1173	629	8	lee	lee	PROPN
ecletica-1173	629	9	,	,	PUNCT
ecletica-1173	629	10	f.	f.	PROPN
ecletica-1173	629	11	y.	y.	PROPN
ecletica-1173	629	12	;	;	PUNCT
ecletica-1173	629	13	chen	chen	PROPN
ecletica-1173	629	14	,	,	PUNCT
ecletica-1173	629	15	p.	p.	PROPN
ecletica-1173	629	16	;	;	PUNCT
ecletica-1173	629	17	norris	norris	PROPN
ecletica-1173	629	18	,	,	PUNCT
ecletica-1173	629	19	d.	d.	PROPN
ecletica-1173	629	20	;	;	PUNCT
ecletica-1173	629	21	barrish	barrish	PROPN
ecletica-1173	629	22	,	,	PUNCT
ecletica-1173	629	23	j.	j.	PROPN
ecletica-1173	629	24	c.	c.	PROPN
ecletica-1173	629	25	;	;	PUNCT
ecletica-1173	629	26	behnia	behnia	PROPN
ecletica-1173	629	27	,	,	PUNCT
ecletica-1173	629	28	k.	k.	PROPN
ecletica-1173	629	29	;	;	PUNCT
ecletica-1173	629	30	castaneda	castaneda	PROPN
ecletica-1173	629	31	,	,	PUNCT
ecletica-1173	629	32	s.	s.	PROPN
ecletica-1173	629	33	;	;	PUNCT
ecletica-1173	629	34	cornelius	cornelius	PROPN
ecletica-1173	629	35	,	,	PUNCT
ecletica-1173	629	36	l.	l.	PROPN
ecletica-1173	629	37	a.	a.	PROPN
ecletica-1173	629	38	m.	m.	PROPN
ecletica-1173	629	39	;	;	PUNCT
ecletica-1173	629	40	das	das	PROPN
ecletica-1173	629	41	,	,	PUNCT
ecletica-1173	629	42	j.	j.	PROPN
ecletica-1173	629	43	;	;	PUNCT
ecletica-1173	629	44	doweyko	doweyko	NOUN
ecletica-1173	629	45	,	,	PUNCT
ecletica-1173	629	46	a.	a.	NOUN
ecletica-1173	629	47	m.	m.	NOUN
ecletica-1173	629	48	;	;	PUNCT
ecletica-1173	629	49	fairchild	fairchild	PROPN
ecletica-1173	629	50	,	,	PUNCT
ecletica-1173	629	51	c.	c.	PROPN
ecletica-1173	629	52	;	;	PUNCT
ecletica-1173	629	53	hunt	hunt	PROPN
ecletica-1173	629	54	,	,	PUNCT
ecletica-1173	629	55	j.	j.	PROPN
ecletica-1173	629	56	t.	t.	PROPN
ecletica-1173	629	57	;	;	PUNCT
ecletica-1173	629	58	inigo	inigo	PROPN
ecletica-1173	629	59	,	,	PUNCT
ecletica-1173	629	60	i.	i.	PROPN
ecletica-1173	629	61	;	;	PUNCT
ecletica-1173	629	62	johnston	johnston	PROPN
ecletica-1173	629	63	,	,	PUNCT
ecletica-1173	629	64	k.	k.	PROPN
ecletica-1173	629	65	;	;	PUNCT
ecletica-1173	629	66	kamath	kamath	PROPN
ecletica-1173	629	67	,	,	PUNCT
ecletica-1173	629	68	a.	a.	PROPN
ecletica-1173	629	69	;	;	PUNCT
ecletica-1173	629	70	kan	kan	PROPN
ecletica-1173	629	71	,	,	PUNCT
ecletica-1173	629	72	d.	d.	PROPN
ecletica-1173	629	73	;	;	PUNCT
ecletica-1173	629	74	klei	klei	PROPN
ecletica-1173	629	75	,	,	PUNCT
ecletica-1173	629	76	h.	h.	PROPN
ecletica-1173	629	77	;	;	PUNCT
ecletica-1173	629	78	marathe	marathe	ADJ
ecletica-1173	629	79	,	,	PUNCT
ecletica-1173	629	80	p.	p.	NOUN
ecletica-1173	629	81	;	;	PUNCT
ecletica-1173	629	82	pang	pang	NOUN
ecletica-1173	629	83	,	,	PUNCT
ecletica-1173	629	84	s.	s.	PROPN
ecletica-1173	629	85	;	;	PUNCT
ecletica-1173	629	86	peterson	peterson	PROPN
ecletica-1173	629	87	,	,	PUNCT
ecletica-1173	629	88	r.	r.	PROPN
ecletica-1173	629	89	;	;	PUNCT
ecletica-1173	629	90	pitt	pitt	PROPN
ecletica-1173	629	91	,	,	PUNCT
ecletica-1173	629	92	s.	s.	PROPN
ecletica-1173	629	93	;	;	PUNCT
ecletica-1173	629	94	schieven	schieven	VERB
ecletica-1173	629	95	,	,	PUNCT
ecletica-1173	629	96	g.	g.	PROPN
ecletica-1173	629	97	l.	l.	PROPN
ecletica-1173	629	98	;	;	PUNCT
ecletica-1173	629	99	schmidt	schmidt	PROPN
ecletica-1173	629	100	,	,	PUNCT
ecletica-1173	629	101	r.	r.	PROPN
ecletica-1173	629	102	j.	j.	PROPN
ecletica-1173	629	103	;	;	PUNCT
ecletica-1173	629	104	tokarski	tokarski	PROPN
ecletica-1173	629	105	,	,	PUNCT
ecletica-1173	629	106	j.	j.	PROPN
ecletica-1173	629	107	;	;	PUNCT
ecletica-1173	629	108	wen	wen	PROPN
ecletica-1173	629	109	,	,	PUNCT
ecletica-1173	629	110	m.-l	m.-l	PROPN
ecletica-1173	629	111	.	.	PUNCT
ecletica-1173	629	112	;	;	PUNCT
ecletica-1173	629	113	wityak	wityak	PROPN
ecletica-1173	629	114	,	,	PUNCT
ecletica-1173	629	115	j.	j.	PROPN
ecletica-1173	629	116	;	;	PUNCT
ecletica-1173	629	117	borzilleri	borzilleri	PROPN
ecletica-1173	629	118	,	,	PUNCT
ecletica-1173	629	119	r.	r.	PROPN
ecletica-1173	629	120	m.	m.	PROPN
ecletica-1173	629	121	discovery	discovery	PROPN
ecletica-1173	629	122	of	of	ADP
ecletica-1173	629	123	n-(2	n-(2	PROPN
ecletica-1173	629	124	-	-	PUNCT
ecletica-1173	629	125	chloro-6	chloro-6	PROPN
ecletica-1173	629	126	-	-	PUNCT
ecletica-1173	629	127	methylphenyl)-2-(6-(4-(2hydroxyethyl)piperazin-1	methylphenyl)-2-(6-(4-(2hydroxyethyl)piperazin-1	PROPN
ecletica-1173	629	128	-	-	PUNCT
ecletica-1173	629	129	yl)-2	yl)-2	NOUN
ecletica-1173	629	130	-	-	PUNCT
ecletica-1173	629	131	methylpyrimidin-4	methylpyrimidin-4	NUM
ecletica-1173	629	132	ylamino)thiazole-5	ylamino)thiazole-5	NOUN
ecletica-1173	629	133	-	-	PUNCT
ecletica-1173	629	134	carboxamide	carboxamide	NOUN
ecletica-1173	629	135	(	(	PUNCT
ecletica-1173	629	136	bms-354825	bms-354825	NOUN
ecletica-1173	629	137	)	)	PUNCT
ecletica-1173	629	138	,	,	PUNCT
ecletica-1173	629	139	a	a	DET
ecletica-1173	629	140	dual	dual	ADJ
ecletica-1173	629	141	src	src	NOUN
ecletica-1173	629	142	/	/	SYM
ecletica-1173	629	143	abl	abl	PROPN
ecletica-1173	629	144	kinase	kinase	PROPN
ecletica-1173	629	145	inhibitor	inhibitor	NOUN
ecletica-1173	629	146	with	with	ADP
ecletica-1173	629	147	potent	potent	ADJ
ecletica-1173	629	148	antitumor	antitumor	NOUN
ecletica-1173	629	149	activity	activity	NOUN
ecletica-1173	629	150	in	in	ADP
ecletica-1173	629	151	preclinical	preclinical	ADJ
ecletica-1173	629	152	assays	assay	NOUN
ecletica-1173	629	153	.	.	PUNCT
ecletica-1173	630	1	j.	j.	PROPN
ecletica-1173	630	2	med	med	PROPN
ecletica-1173	630	3	.	.	PROPN
ecletica-1173	630	4	chem	chem	PROPN
ecletica-1173	630	5	.	.	PUNCT
ecletica-1173	631	1	2004	2004	NUM
ecletica-1173	631	2	,	,	PUNCT
ecletica-1173	631	3	47	47	NUM
ecletica-1173	631	4	(	(	PUNCT
ecletica-1173	631	5	27	27	NUM
ecletica-1173	631	6	)	)	PUNCT
ecletica-1173	631	7	,	,	PUNCT
ecletica-1173	631	8	6658	6658	NUM
ecletica-1173	631	9	–	–	PUNCT
ecletica-1173	631	10	6661	6661	NUM
ecletica-1173	631	11	.	.	PUNCT
ecletica-1173	632	1	https://doi.org/10.1021/jm049486a	https://doi.org/10.1021/jm049486a	PROPN
ecletica-1173	632	2	.	.	PUNCT
ecletica-1173	633	1	löwdin	löwdin	VERB
ecletica-1173	633	2	,	,	PUNCT
ecletica-1173	633	3	p.-o	p.-o	NOUN
ecletica-1173	633	4	.	.	PUNCT
ecletica-1173	634	1	quantum	quantum	ADJ
ecletica-1173	634	2	theory	theory	NOUN
ecletica-1173	634	3	of	of	ADP
ecletica-1173	634	4	many	many	ADJ
ecletica-1173	634	5	-	-	PUNCT
ecletica-1173	634	6	particle	particle	NOUN
ecletica-1173	634	7	systems	system	NOUN
ecletica-1173	634	8	.	.	PUNCT
ecletica-1173	635	1	iii	iii	X
ecletica-1173	635	2	.	.	PUNCT
ecletica-1173	635	3	extension	extension	NOUN
ecletica-1173	635	4	of	of	ADP
ecletica-1173	635	5	the	the	DET
ecletica-1173	635	6	hartree	hartree	ADV
ecletica-1173	635	7	-	-	PUNCT
ecletica-1173	635	8	fock	fock	ADJ
ecletica-1173	635	9	scheme	scheme	NOUN
ecletica-1173	635	10	to	to	PART
ecletica-1173	635	11	include	include	VERB
ecletica-1173	635	12	degenerate	degenerate	ADJ
ecletica-1173	635	13	systems	system	NOUN
ecletica-1173	635	14	and	and	CCONJ
ecletica-1173	635	15	correlation	correlation	NOUN
ecletica-1173	635	16	effects	effect	NOUN
ecletica-1173	635	17	.	.	PUNCT
ecletica-1173	636	1	phys	phy	NOUN
ecletica-1173	636	2	.	.	PUNCT
ecletica-1173	637	1	rev	rev	PROPN
ecletica-1173	637	2	.	.	PROPN
ecletica-1173	637	3	1955	1955	NUM
ecletica-1173	637	4	,	,	PUNCT
ecletica-1173	637	5	97	97	NUM
ecletica-1173	637	6	(	(	PUNCT
ecletica-1173	637	7	6	6	NUM
ecletica-1173	637	8	)	)	PUNCT
ecletica-1173	637	9	,	,	PUNCT
ecletica-1173	637	10	1509	1509	NUM
ecletica-1173	637	11	-	-	SYM
ecletica-1173	637	12	1520	1520	NUM
ecletica-1173	637	13	.	.	PUNCT
ecletica-1173	638	1	https://doi.org/10.1103/physrev.97.1509	https://doi.org/10.1103/physrev.97.1509	NOUN
ecletica-1173	638	2	.	.	PUNCT
ecletica-1173	639	1	manley	manley	PROPN
ecletica-1173	639	2	,	,	PUNCT
ecletica-1173	639	3	p.	p.	PROPN
ecletica-1173	639	4	w.	w.	PROPN
ecletica-1173	639	5	;	;	PUNCT
ecletica-1173	639	6	cowan	cowan	PROPN
ecletica-1173	639	7	-	-	PUNCT
ecletica-1173	639	8	jacob	jacob	PROPN
ecletica-1173	639	9	,	,	PUNCT
ecletica-1173	639	10	s.	s.	PROPN
ecletica-1173	639	11	w.	w.	PROPN
ecletica-1173	639	12	;	;	PUNCT
ecletica-1173	639	13	buchdunger	buchdunger	NOUN
ecletica-1173	639	14	,	,	PUNCT
ecletica-1173	639	15	e.	e.	PROPN
ecletica-1173	639	16	;	;	PUNCT
ecletica-1173	639	17	fabbro	fabbro	PROPN
ecletica-1173	639	18	,	,	PUNCT
ecletica-1173	639	19	d.	d.	PROPN
ecletica-1173	639	20	;	;	PUNCT
ecletica-1173	639	21	fendrich	fendrich	NOUN
ecletica-1173	639	22	,	,	PUNCT
ecletica-1173	639	23	g.	g.	PROPN
ecletica-1173	639	24	;	;	PUNCT
ecletica-1173	639	25	furet	furet	PROPN
ecletica-1173	639	26	,	,	PUNCT
ecletica-1173	639	27	p.	p.	PROPN
ecletica-1173	639	28	;	;	PUNCT
ecletica-1173	639	29	meyer	meyer	PROPN
ecletica-1173	639	30	,	,	PUNCT
ecletica-1173	639	31	t.	t.	PROPN
ecletica-1173	639	32	;	;	PUNCT
ecletica-1173	639	33	zimmermann	zimmermann	PROPN
ecletica-1173	639	34	,	,	PUNCT
ecletica-1173	639	35	j.	j.	PROPN
ecletica-1173	639	36	imatinib	imatinib	PROPN
ecletica-1173	639	37	:	:	PUNCT
ecletica-1173	639	38	a	a	DET
ecletica-1173	639	39	selective	selective	ADJ
ecletica-1173	639	40	tyrosine	tyrosine	NOUN
ecletica-1173	639	41	kinase	kinase	PROPN
ecletica-1173	639	42	inhibitor	inhibitor	PROPN
ecletica-1173	639	43	.	.	PUNCT
ecletica-1173	640	1	eur	eur	PROPN
ecletica-1173	640	2	.	.	PUNCT
ecletica-1173	641	1	j.	j.	PROPN
ecletica-1173	641	2	cancer	cancer	PROPN
ecletica-1173	641	3	2002	2002	NUM
ecletica-1173	641	4	,	,	PUNCT
ecletica-1173	641	5	38	38	NUM
ecletica-1173	641	6	(	(	PUNCT
ecletica-1173	641	7	suppl	suppl	NOUN
ecletica-1173	641	8	5	5	NUM
ecletica-1173	641	9	)	)	PUNCT
ecletica-1173	641	10	,	,	PUNCT
ecletica-1173	641	11	s19	s19	PROPN
ecletica-1173	641	12	–	–	PUNCT
ecletica-1173	641	13	s27	s27	PROPN
ecletica-1173	641	14	.	.	PUNCT
ecletica-1173	642	1	https://doi.org/10.1016/s0959-8049(02)80599-8	https://doi.org/10.1016/s0959-8049(02)80599-8	PROPN
ecletica-1173	642	2	.	.	PUNCT
ecletica-1173	643	1	menzies	menzie	NOUN
ecletica-1173	643	2	,	,	PUNCT
ecletica-1173	643	3	p.	p.	NOUN
ecletica-1173	643	4	against	against	ADP
ecletica-1173	643	5	causal	causal	ADJ
ecletica-1173	643	6	reductionism	reductionism	NOUN
ecletica-1173	643	7	.	.	PUNCT
ecletica-1173	644	1	mind	mind	NOUN
ecletica-1173	644	2	1988	1988	NUM
ecletica-1173	644	3	,	,	PUNCT
ecletica-1173	644	4	388	388	NUM
ecletica-1173	644	5	,	,	PUNCT
ecletica-1173	644	6	551–574	551–574	NUM
ecletica-1173	644	7	.	.	PUNCT
ecletica-1173	645	1	https://doi.org/10.1093/mind/xcvii.388.551	https://doi.org/10.1093/mind/xcvii.388.551	PROPN
ecletica-1173	645	2	.	.	PUNCT
ecletica-1173	646	1	miska	miska	PROPN
ecletica-1173	646	2	,	,	PUNCT
ecletica-1173	646	3	d.	d.	PROPN
ecletica-1173	646	4	biotech	biotech	PROPN
ecletica-1173	646	5	’s	’s	PART
ecletica-1173	646	6	twentieth	twentieth	ADJ
ecletica-1173	646	7	birthday	birthday	NOUN
ecletica-1173	646	8	blues	blue	NOUN
ecletica-1173	646	9	.	.	PUNCT
ecletica-1173	647	1	nat	nat	PROPN
ecletica-1173	647	2	.	.	PUNCT
ecletica-1173	648	1	rev	rev	PROPN
ecletica-1173	648	2	.	.	PROPN
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ecletica-1173	648	5	.	.	PUNCT
ecletica-1173	649	1	2003	2003	NUM
ecletica-1173	649	2	,	,	PUNCT
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ecletica-1173	649	4	,	,	PUNCT
ecletica-1173	649	5	231–233	231–233	NUM
ecletica-1173	649	6	.	.	PUNCT
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ecletica-1173	650	2	.	.	PUNCT
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ecletica-1173	651	9	https://doi.org/10.1017/s0305004100011920	https://doi.org/10.1017/s0305004100011920	NUM
ecletica-1173	651	10	https://doi.org/10.1017/s0305004100011920	https://doi.org/10.1017/s0305004100011920	NUM
ecletica-1173	651	11	https://doi.org/10.1017/s0305004100011920	https://doi.org/10.1017/s0305004100011920	NUM
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ecletica-1173	651	13	https://doi.org/10.1017/s0305004100015954	https://doi.org/10.1017/s0305004100015954	NUM
ecletica-1173	651	14	https://doi.org/10.1017/s0305004100015954	https://doi.org/10.1017/s0305004100015954	NUM
ecletica-1173	651	15	https://doi.org/10.1017/s0305004100015954	https://doi.org/10.1017/s0305004100015954	NUM
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ecletica-1173	651	19	https://doi.org/10.1038/nbt1201-1099	https://doi.org/10.1038/nbt1201-1099	X
ecletica-1173	651	20	https://doi.org/10.1126/science.1079731	https://doi.org/10.1126/science.1079731	NOUN
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ecletica-1173	651	30	https://doi.org/10.1038/nrd2683	https://doi.org/10.1038/nrd2683	NOUN
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ecletica-1173	651	32	https://doi.org/10.13070/mm.en.3.160	https://doi.org/10.13070/mm.en.3.160	NOUN
ecletica-1173	651	33	https://doi.org/10.13070/mm.en.3.160	https://doi.org/10.13070/mm.en.3.160	ADJ
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ecletica-1173	651	36	https://doi.org/10.1007/bf01392901	https://doi.org/10.1007/bf01392901	NOUN
ecletica-1173	651	37	https://doi.org/10.1038/nature08506	https://doi.org/10.1038/nature08506	NOUN
ecletica-1173	651	38	https://doi.org/10.1038/nature08506	https://doi.org/10.1038/nature08506	NOUN
ecletica-1173	651	39	https://doi.org/10.1038/nature08506	https://doi.org/10.1038/nature08506	NOUN
ecletica-1173	651	40	https://doi.org/10.1038/nature08506	https://doi.org/10.1038/nature08506	NOUN
ecletica-1173	651	41	https://doi.org/10.1038/nature08506	https://doi.org/10.1038/nature08506	NOUN
ecletica-1173	651	42	https://doi.org/10.1038/nature08506	https://doi.org/10.1038/nature08506	NOUN
ecletica-1173	652	1	https://doi.org/10.1073/pnas.44.2.98	https://doi.org/10.1073/pnas.44.2.98	X
ecletica-1173	652	2	https://doi.org/10.1073/pnas.44.2.98	https://doi.org/10.1073/pnas.44.2.98	ADV
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ecletica-1173	652	4	https://doi.org/10.1016/j.neuron.2016.12.041	https://doi.org/10.1016/j.neuron.2016.12.041	VERB
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ecletica-1173	653	4	https://doi.org/10.1142/9789812777843_0040	https://doi.org/10.1142/9789812777843_0040	ADV
ecletica-1173	653	5	https://doi.org/10.1142/9789812777843_0040	https://doi.org/10.1142/9789812777843_0040	X
ecletica-1173	653	6	https://doi.org/10.1142/9789812777843_0040	https://doi.org/10.1142/9789812777843_0040	X
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ecletica-1173	653	25	https://doi.org/10.1021/jm049486a	https://doi.org/10.1021/jm049486a	PROPN
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ecletica-1173	653	30	https://doi.org/10.1021/jm049486a	https://doi.org/10.1021/jm049486a	PROPN
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ecletica-1173	654	18	,	,	PUNCT
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ecletica-1173	654	21	,	,	PUNCT
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ecletica-1173	654	30	-	-	SYM
ecletica-1173	654	31	4618	4618	NUM
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ecletica-1173	654	37	-	-	PUNCT
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ecletica-1173	654	44	,	,	PUNCT
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ecletica-1173	654	46	a.	a.	PROPN
ecletica-1173	654	47	;	;	PUNCT
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ecletica-1173	654	59	-	-	PUNCT
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ecletica-1173	654	61	bisubstrate	bisubstrate	NOUN
ecletica-1173	654	62	-	-	PUNCT
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ecletica-1173	654	66	protein	protein	NOUN
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ecletica-1173	655	4	,	,	PUNCT
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ecletica-1173	655	7	1	1	NUM
ecletica-1173	655	8	)	)	PUNCT
ecletica-1173	655	9	,	,	PUNCT
ecletica-1173	655	10	775	775	NUM
ecletica-1173	655	11	-	-	SYM
ecletica-1173	655	12	784	784	NUM
ecletica-1173	655	13	.	.	PUNCT
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ecletica-1173	657	6	)	)	PUNCT
ecletica-1173	657	7	.	.	PUNCT
ecletica-1173	658	1	in	in	ADP
ecletica-1173	658	2	:	:	PUNCT
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ecletica-1173	658	4	.	.	PUNCT
ecletica-1173	659	1	qeios	qeio	NOUN
ecletica-1173	659	2	,	,	PUNCT
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ecletica-1173	659	4	.	.	PUNCT
ecletica-1173	660	1	https://www.cancer.gov/	https://www.cancer.gov/	PROPN
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ecletica-1173	660	5	-	-	SYM
ecletica-1173	660	6	02	02	NUM
ecletica-1173	660	7	-	-	PUNCT
ecletica-1173	660	8	21	21	NUM
ecletica-1173	660	9	)	)	PUNCT
ecletica-1173	660	10	.	.	PUNCT
ecletica-1173	661	1	nicholson	nicholson	PROPN
ecletica-1173	661	2	,	,	PUNCT
ecletica-1173	661	3	d.	d.	PROPN
ecletica-1173	661	4	j.	j.	PROPN
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ecletica-1173	661	9	a	a	DET
ecletica-1173	661	10	machine	machine	NOUN
ecletica-1173	661	11	?	?	PUNCT
ecletica-1173	662	1	j.	j.	PROPN
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ecletica-1173	662	3	.	.	PUNCT
ecletica-1173	663	1	biol	biol	PROPN
ecletica-1173	663	2	.	.	PUNCT
ecletica-1173	664	1	2019	2019	NUM
ecletica-1173	664	2	,	,	PUNCT
ecletica-1173	664	3	477	477	NUM
ecletica-1173	664	4	,	,	PUNCT
ecletica-1173	664	5	108–26	108–26	NUM
ecletica-1173	664	6	.	.	PUNCT
ecletica-1173	664	7	https://doi.org/10.1016/j.jtbi.2019.06.002	https://doi.org/10.1016/j.jtbi.2019.06.002	NOUN
ecletica-1173	664	8	.	.	PUNCT
ecletica-1173	665	1	nurse	nurse	PROPN
ecletica-1173	665	2	,	,	PUNCT
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ecletica-1173	665	8	.	.	PUNCT
ecletica-1173	666	1	nature	nature	NOUN
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ecletica-1173	666	3	,	,	PUNCT
ecletica-1173	666	4	387	387	NUM
ecletica-1173	666	5	(	(	PUNCT
ecletica-1173	666	6	6634	6634	NUM
ecletica-1173	666	7	)	)	PUNCT
ecletica-1173	666	8	,	,	PUNCT
ecletica-1173	666	9	657	657	NUM
ecletica-1173	666	10	.	.	PUNCT
ecletica-1173	667	1	https://doi.org/10.1038/42600	https://doi.org/10.1038/42600	NOUN
ecletica-1173	667	2	.	.	PUNCT
ecletica-1173	668	1	o’sullivan	o’sullivan	PROPN
ecletica-1173	668	2	,	,	PUNCT
ecletica-1173	668	3	a.	a.	NOUN
ecletica-1173	668	4	;	;	PUNCT
ecletica-1173	668	5	henrick	henrick	PROPN
ecletica-1173	668	6	,	,	PUNCT
ecletica-1173	668	7	b.	b.	PROPN
ecletica-1173	668	8	;	;	PUNCT
ecletica-1173	668	9	dixon	dixon	PROPN
ecletica-1173	668	10	,	,	PUNCT
ecletica-1173	668	11	b.	b.	PROPN
ecletica-1173	668	12	;	;	PUNCT
ecletica-1173	668	13	barile	barile	PROPN
ecletica-1173	668	14	,	,	PUNCT
ecletica-1173	668	15	d.	d.	PROPN
ecletica-1173	668	16	;	;	PUNCT
ecletica-1173	668	17	zivkovic	zivkovic	NOUN
ecletica-1173	668	18	,	,	PUNCT
ecletica-1173	668	19	a.	a.	NOUN
ecletica-1173	668	20	;	;	PUNCT
ecletica-1173	668	21	smilowitz	smilowitz	PROPN
ecletica-1173	668	22	,	,	PUNCT
ecletica-1173	668	23	j.	j.	PROPN
ecletica-1173	668	24	;	;	PUNCT
ecletica-1173	668	25	lemay	lemay	PROPN
ecletica-1173	668	26	,	,	PUNCT
ecletica-1173	668	27	d.	d.	PROPN
ecletica-1173	668	28	;	;	PUNCT
ecletica-1173	668	29	martin	martin	PROPN
ecletica-1173	668	30	,	,	PUNCT
ecletica-1173	668	31	w.	w.	PROPN
ecletica-1173	668	32	;	;	PUNCT
ecletica-1173	668	33	german	german	ADJ
ecletica-1173	668	34	,	,	PUNCT
ecletica-1173	668	35	j.	j.	PROPN
ecletica-1173	668	36	b.	b.	PROPN
ecletica-1173	668	37	;	;	PUNCT
ecletica-1173	668	38	schaefer	schaefer	PROPN
ecletica-1173	668	39	,	,	PUNCT
ecletica-1173	668	40	s.	s.	PROPN
ecletica-1173	668	41	e.	e.	PROPN
ecletica-1173	668	42	21st	21st	PROPN
ecletica-1173	668	43	century	century	NOUN
ecletica-1173	668	44	toolkit	toolkit	NOUN
ecletica-1173	668	45	for	for	ADP
ecletica-1173	668	46	optimizing	optimize	VERB
ecletica-1173	668	47	population	population	NOUN
ecletica-1173	668	48	health	health	NOUN
ecletica-1173	668	49	through	through	ADP
ecletica-1173	668	50	precision	precision	NOUN
ecletica-1173	668	51	nutrition	nutrition	NOUN
ecletica-1173	668	52	.	.	PUNCT
ecletica-1173	669	1	crit	crit	PROPN
ecletica-1173	669	2	.	.	PUNCT
ecletica-1173	670	1	rev	rev	PROPN
ecletica-1173	670	2	.	.	PROPN
ecletica-1173	670	3	food	food	PROPN
ecletica-1173	670	4	sci	sci	PROPN
ecletica-1173	670	5	.	.	PUNCT
ecletica-1173	670	6	nutr	nutr	PROPN
ecletica-1173	670	7	.	.	PROPN
ecletica-1173	670	8	2018	2018	NUM
ecletica-1173	670	9	,	,	PUNCT
ecletica-1173	670	10	58	58	NUM
ecletica-1173	670	11	(	(	PUNCT
ecletica-1173	670	12	17	17	NUM
ecletica-1173	670	13	)	)	PUNCT
ecletica-1173	670	14	,	,	PUNCT
ecletica-1173	670	15	3004–3015	3004–3015	NUM
ecletica-1173	670	16	.	.	PUNCT
ecletica-1173	671	1	https://doi.org/10.1080/10408398.2017.1348335	https://doi.org/10.1080/10408398.2017.1348335	PROPN
ecletica-1173	671	2	.	.	PUNCT
ecletica-1173	671	3	omenn	omenn	PROPN
ecletica-1173	671	4	,	,	PUNCT
ecletica-1173	671	5	g.	g.	PROPN
ecletica-1173	671	6	s.	s.	PROPN
ecletica-1173	671	7	;	;	PUNCT
ecletica-1173	671	8	goodman	goodman	PROPN
ecletica-1173	671	9	,	,	PUNCT
ecletica-1173	671	10	g.	g.	PROPN
ecletica-1173	671	11	e.	e.	PROPN
ecletica-1173	671	12	;	;	PUNCT
ecletica-1173	671	13	thornquist	thornquist	NOUN
ecletica-1173	671	14	,	,	PUNCT
ecletica-1173	671	15	m.	m.	NOUN
ecletica-1173	671	16	d.	d.	PROPN
ecletica-1173	671	17	;	;	PUNCT
ecletica-1173	671	18	balmes	balmes	PROPN
ecletica-1173	671	19	,	,	PUNCT
ecletica-1173	671	20	j.	j.	PROPN
ecletica-1173	671	21	;	;	PUNCT
ecletica-1173	671	22	cullen	cullen	PROPN
ecletica-1173	671	23	,	,	PUNCT
ecletica-1173	671	24	m.	m.	NOUN
ecletica-1173	671	25	r.	r.	PROPN
ecletica-1173	671	26	;	;	PUNCT
ecletica-1173	671	27	glass	glass	NOUN
ecletica-1173	671	28	,	,	PUNCT
ecletica-1173	671	29	a.	a.	NOUN
ecletica-1173	671	30	;	;	PUNCT
ecletica-1173	671	31	keogh	keogh	PROPN
ecletica-1173	671	32	,	,	PUNCT
ecletica-1173	671	33	j.	j.	PROPN
ecletica-1173	671	34	p.	p.	PROPN
ecletica-1173	671	35	;	;	PUNCT
ecletica-1173	671	36	meyskens	meysken	NOUN
ecletica-1173	671	37	junior	junior	PROPN
ecletica-1173	671	38	,	,	PUNCT
ecletica-1173	671	39	f.	f.	PROPN
ecletica-1173	671	40	l.	l.	PROPN
ecletica-1173	671	41	;	;	PUNCT
ecletica-1173	671	42	valanis	valanis	PROPN
ecletica-1173	671	43	,	,	PUNCT
ecletica-1173	671	44	b.	b.	PROPN
ecletica-1173	671	45	;	;	PUNCT
ecletica-1173	671	46	williams	williams	PROPN
ecletica-1173	671	47	junior	junior	PROPN
ecletica-1173	671	48	,	,	PUNCT
ecletica-1173	671	49	j.	j.	PROPN
ecletica-1173	671	50	m.	m.	PROPN
ecletica-1173	671	51	;	;	PUNCT
ecletica-1173	671	52	barnhart	barnhart	PROPN
ecletica-1173	671	53	,	,	PUNCT
ecletica-1173	671	54	s.	s.	PROPN
ecletica-1173	671	55	;	;	PUNCT
ecletica-1173	671	56	cherniack	cherniack	NOUN
ecletica-1173	671	57	,	,	PUNCT
ecletica-1173	671	58	m.	m.	NOUN
ecletica-1173	671	59	g.	g.	PROPN
ecletica-1173	671	60	;	;	PUNCT
ecletica-1173	671	61	brodkin	brodkin	PROPN
ecletica-1173	671	62	,	,	PUNCT
ecletica-1173	671	63	c.	c.	PROPN
ecletica-1173	671	64	a.	a.	PROPN
ecletica-1173	671	65	;	;	PUNCT
ecletica-1173	671	66	hammar	hammar	PROPN
ecletica-1173	671	67	,	,	PUNCT
ecletica-1173	671	68	s.	s.	PROPN
ecletica-1173	671	69	risk	risk	NOUN
ecletica-1173	671	70	factors	factor	NOUN
ecletica-1173	671	71	for	for	ADP
ecletica-1173	671	72	lung	lung	NOUN
ecletica-1173	671	73	cancer	cancer	NOUN
ecletica-1173	671	74	and	and	CCONJ
ecletica-1173	671	75	for	for	ADP
ecletica-1173	671	76	intervention	intervention	NOUN
ecletica-1173	671	77	effects	effect	NOUN
ecletica-1173	671	78	in	in	ADP
ecletica-1173	671	79	caret	caret	PROPN
ecletica-1173	671	80	,	,	PUNCT
ecletica-1173	671	81	the	the	DET
ecletica-1173	671	82	beta	beta	NOUN
ecletica-1173	671	83	-	-	PUNCT
ecletica-1173	671	84	carotene	carotene	NOUN
ecletica-1173	671	85	and	and	CCONJ
ecletica-1173	671	86	retinol	retinol	NOUN
ecletica-1173	671	87	efficacy	efficacy	NOUN
ecletica-1173	671	88	trial	trial	NOUN
ecletica-1173	671	89	.	.	PUNCT
ecletica-1173	672	1	j.	j.	PROPN
ecletica-1173	672	2	natl	natl	PROPN
ecletica-1173	672	3	.	.	PUNCT
ecletica-1173	672	4	cancer	cancer	PROPN
ecletica-1173	672	5	inst	inst	PROPN
ecletica-1173	672	6	.	.	PUNCT
ecletica-1173	672	7	1996	1996	NUM
ecletica-1173	672	8	,	,	PUNCT
ecletica-1173	672	9	88	88	NUM
ecletica-1173	672	10	(	(	PUNCT
ecletica-1173	672	11	21	21	NUM
ecletica-1173	672	12	)	)	PUNCT
ecletica-1173	672	13	,	,	PUNCT
ecletica-1173	672	14	1550–1559	1550–1559	NUM
ecletica-1173	672	15	.	.	PUNCT
ecletica-1173	673	1	https://doi.org/10.1093/jnci/88.21.1550	https://doi.org/10.1093/jnci/88.21.1550	PROPN
ecletica-1173	673	2	.	.	PUNCT
ecletica-1173	674	1	pal	pal	PROPN
ecletica-1173	674	2	,	,	PUNCT
ecletica-1173	674	3	r.	r.	PROPN
ecletica-1173	674	4	;	;	PUNCT
ecletica-1173	674	5	berlow	berlow	NOUN
ecletica-1173	674	6	,	,	PUNCT
ecletica-1173	674	7	n.	n.	PROPN
ecletica-1173	674	8	a	a	DET
ecletica-1173	674	9	kinase	kinase	PROPN
ecletica-1173	674	10	inhibition	inhibition	NOUN
ecletica-1173	674	11	map	map	NOUN
ecletica-1173	674	12	approach	approach	NOUN
ecletica-1173	674	13	for	for	ADP
ecletica-1173	674	14	tumor	tumor	NOUN
ecletica-1173	674	15	sensitivity	sensitivity	NOUN
ecletica-1173	674	16	prediction	prediction	NOUN
ecletica-1173	674	17	and	and	CCONJ
ecletica-1173	674	18	combination	combination	NOUN
ecletica-1173	674	19	therapy	therapy	NOUN
ecletica-1173	674	20	design	design	NOUN
ecletica-1173	674	21	for	for	ADP
ecletica-1173	674	22	targeted	target	VERB
ecletica-1173	674	23	drugs	drug	NOUN
ecletica-1173	674	24	.	.	PUNCT
ecletica-1173	675	1	pacific	pacific	ADJ
ecletica-1173	675	2	symp	symp	PROPN
ecletica-1173	675	3	.	.	PUNCT
ecletica-1173	676	1	biocomput	biocomput	NOUN
ecletica-1173	676	2	.	.	PUNCT
ecletica-1173	677	1	2012	2012	NUM
ecletica-1173	677	2	,	,	PUNCT
ecletica-1173	677	3	351–362	351–362	NUM
ecletica-1173	677	4	.	.	PUNCT
ecletica-1173	678	1	https://doi.org/10.1142/9789814366496_0034	https://doi.org/10.1142/9789814366496_0034	PROPN
ecletica-1173	678	2	.	.	PUNCT
ecletica-1173	678	3	patani	patani	PROPN
ecletica-1173	678	4	,	,	PUNCT
ecletica-1173	678	5	g.	g.	PROPN
ecletica-1173	678	6	a.	a.	PROPN
ecletica-1173	678	7	;	;	PUNCT
ecletica-1173	679	1	lavoie	lavoie	PROPN
ecletica-1173	679	2	,	,	PUNCT
ecletica-1173	679	3	e.	e.	PROPN
ecletica-1173	679	4	j.	j.	PROPN
ecletica-1173	679	5	bioisosterism	bioisosterism	PROPN
ecletica-1173	679	6	:	:	PUNCT
ecletica-1173	679	7	a	a	DET
ecletica-1173	679	8	rational	rational	ADJ
ecletica-1173	679	9	approach	approach	NOUN
ecletica-1173	679	10	in	in	ADP
ecletica-1173	679	11	drug	drug	NOUN
ecletica-1173	679	12	design	design	NOUN
ecletica-1173	679	13	.	.	PUNCT
ecletica-1173	680	1	chem	chem	PROPN
ecletica-1173	680	2	.	.	PUNCT
ecletica-1173	681	1	rev	rev	PROPN
ecletica-1173	681	2	.	.	PROPN
ecletica-1173	681	3	1996	1996	NUM
ecletica-1173	681	4	,	,	PUNCT
ecletica-1173	681	5	96	96	NUM
ecletica-1173	681	6	(	(	PUNCT
ecletica-1173	681	7	8)	8)	NUM
ecletica-1173	681	8	,	,	PUNCT
ecletica-1173	681	9	3147	3147	NUM
ecletica-1173	681	10	–	–	PUNCT
ecletica-1173	681	11	3176	3176	NUM
ecletica-1173	681	12	.	.	PUNCT
ecletica-1173	682	1	https://doi.org/10.1021/cr950066q	https://doi.org/10.1021/cr950066q	PROPN
ecletica-1173	682	2	.	.	PUNCT
ecletica-1173	683	1	peterson	peterson	PROPN
ecletica-1173	683	2	,	,	PUNCT
ecletica-1173	683	3	r.	r.	PROPN
ecletica-1173	683	4	t.	t.	PROPN
ecletica-1173	683	5	chemical	chemical	PROPN
ecletica-1173	683	6	biology	biology	NOUN
ecletica-1173	683	7	and	and	CCONJ
ecletica-1173	683	8	the	the	DET
ecletica-1173	683	9	limits	limit	NOUN
ecletica-1173	683	10	of	of	ADP
ecletica-1173	683	11	reductionism	reductionism	NOUN
ecletica-1173	683	12	.	.	PUNCT
ecletica-1173	684	1	nat	nat	PROPN
ecletica-1173	684	2	.	.	PUNCT
ecletica-1173	685	1	chem	chem	PROPN
ecletica-1173	685	2	.	.	PUNCT
ecletica-1173	686	1	biol	biol	PROPN
ecletica-1173	686	2	.	.	PUNCT
ecletica-1173	687	1	2008	2008	NUM
ecletica-1173	687	2	,	,	PUNCT
ecletica-1173	687	3	4	4	NUM
ecletica-1173	687	4	(	(	PUNCT
ecletica-1173	687	5	11	11	NUM
ecletica-1173	687	6	)	)	PUNCT
ecletica-1173	687	7	,	,	PUNCT
ecletica-1173	687	8	635–638	635–638	NUM
ecletica-1173	687	9	.	.	PUNCT
ecletica-1173	688	1	https://doi.org/10.1038/nchembio1108-635	https://doi.org/10.1038/nchembio1108-635	PROPN
ecletica-1173	688	2	.	.	PUNCT
ecletica-1173	688	3	phua	phua	PROPN
ecletica-1173	688	4	,	,	PUNCT
ecletica-1173	688	5	s.-x	s.-x	NOUN
ecletica-1173	688	6	.	.	PUNCT
ecletica-1173	688	7	;	;	PUNCT
ecletica-1173	688	8	chan	chan	PROPN
ecletica-1173	688	9	,	,	PUNCT
ecletica-1173	688	10	k.-f	k.-f	PROPN
ecletica-1173	688	11	.	.	PUNCT
ecletica-1173	688	12	;	;	PUNCT
ecletica-1173	688	13	su	su	PROPN
ecletica-1173	688	14	,	,	PUNCT
ecletica-1173	688	15	c.	c.	PROPN
ecletica-1173	688	16	t.-t	t.-t	PROPN
ecletica-1173	688	17	.	.	PUNCT
ecletica-1173	688	18	;	;	PUNCT
ecletica-1173	688	19	poh	poh	PROPN
ecletica-1173	688	20	,	,	PUNCT
ecletica-1173	688	21	j.-j	j.-j	PROPN
ecletica-1173	688	22	.	.	PUNCT
ecletica-1173	688	23	;	;	PUNCT
ecletica-1173	688	24	gan	gan	PROPN
ecletica-1173	688	25	,	,	PUNCT
ecletica-1173	688	26	s.	s.	PROPN
ecletica-1173	688	27	k.e	k.e	PROPN
ecletica-1173	688	28	.	.	PROPN
ecletica-1173	689	1	perspective	perspective	PROPN
ecletica-1173	689	2	:	:	PUNCT
ecletica-1173	689	3	the	the	DET
ecletica-1173	689	4	promises	promise	NOUN
ecletica-1173	689	5	of	of	ADP
ecletica-1173	689	6	a	a	DET
ecletica-1173	689	7	holistic	holistic	ADJ
ecletica-1173	689	8	view	view	NOUN
ecletica-1173	689	9	of	of	ADP
ecletica-1173	689	10	proteins	protein	NOUN
ecletica-1173	689	11	—	—	PUNCT
ecletica-1173	689	12	impact	impact	NOUN
ecletica-1173	689	13	on	on	ADP
ecletica-1173	689	14	antibody	antibody	NOUN
ecletica-1173	689	15	engineering	engineering	NOUN
ecletica-1173	689	16	and	and	CCONJ
ecletica-1173	689	17	drug	drug	NOUN
ecletica-1173	689	18	discovery	discovery	NOUN
ecletica-1173	689	19	.	.	PUNCT
ecletica-1173	690	1	biosci	biosci	PROPN
ecletica-1173	690	2	.	.	PUNCT
ecletica-1173	691	1	rep	rep	PROPN
ecletica-1173	691	2	.	.	PROPN
ecletica-1173	691	3	2019	2019	NUM
ecletica-1173	691	4	,	,	PUNCT
ecletica-1173	691	5	39	39	NUM
ecletica-1173	691	6	(	(	PUNCT
ecletica-1173	691	7	1	1	NUM
ecletica-1173	691	8	)	)	PUNCT
ecletica-1173	691	9	,	,	PUNCT
ecletica-1173	691	10	bsr20181958	bsr20181958	NOUN
ecletica-1173	691	11	.	.	PUNCT
ecletica-1173	692	1	https://doi.org/10.1042/bsr20181958	https://doi.org/10.1042/bsr20181958	X
ecletica-1173	692	2	.	.	PUNCT
ecletica-1173	693	1	pierce	pierce	PROPN
ecletica-1173	693	2	junior	junior	PROPN
ecletica-1173	693	3	,	,	PUNCT
ecletica-1173	693	4	g.	g.	PROPN
ecletica-1173	693	5	b.	b.	PROPN
ecletica-1173	693	6	;	;	PUNCT
ecletica-1173	693	7	dixon	dixon	PROPN
ecletica-1173	693	8	junior	junior	PROPN
ecletica-1173	693	9	,	,	PUNCT
ecletica-1173	693	10	f.	f.	PROPN
ecletica-1173	693	11	j.	j.	PROPN
ecletica-1173	693	12	;	;	PUNCT
ecletica-1173	693	13	verney	verney	PROPN
ecletica-1173	693	14	,	,	PUNCT
ecletica-1173	693	15	e.	e.	PROPN
ecletica-1173	693	16	l.	l.	PROPN
ecletica-1173	693	17	teratocarcinogenic	teratocarcinogenic	PROPN
ecletica-1173	693	18	and	and	CCONJ
ecletica-1173	693	19	tissue	tissue	NOUN
ecletica-1173	693	20	-	-	PUNCT
ecletica-1173	693	21	forming	form	VERB
ecletica-1173	693	22	potentials	potential	NOUN
ecletica-1173	693	23	of	of	ADP
ecletica-1173	693	24	the	the	DET
ecletica-1173	693	25	cell	cell	NOUN
ecletica-1173	693	26	types	type	NOUN
ecletica-1173	693	27	comprising	comprise	VERB
ecletica-1173	693	28	neoplastic	neoplastic	ADJ
ecletica-1173	693	29	embryoid	embryoid	NUM
ecletica-1173	693	30	bodies	body	NOUN
ecletica-1173	693	31	.	.	PUNCT
ecletica-1173	694	1	lab	lab	NOUN
ecletica-1173	694	2	invest	invest	PROPN
ecletica-1173	694	3	.	.	PUNCT
ecletica-1173	695	1	1960	1960	NUM
ecletica-1173	695	2	,	,	PUNCT
ecletica-1173	695	3	9	9	NUM
ecletica-1173	695	4	,	,	PUNCT
ecletica-1173	695	5	583–602	583–602	NUM
ecletica-1173	695	6	.	.	PUNCT
ecletica-1173	696	1	pigliucci	pigliucci	PROPN
ecletica-1173	696	2	,	,	PUNCT
ecletica-1173	696	3	m.	m.	NOUN
ecletica-1173	696	4	;	;	PUNCT
ecletica-1173	696	5	kaplan	kaplan	PROPN
ecletica-1173	696	6	,	,	PUNCT
ecletica-1173	696	7	j.	j.	PROPN
ecletica-1173	696	8	making	make	VERB
ecletica-1173	696	9	sense	sense	NOUN
ecletica-1173	696	10	of	of	ADP
ecletica-1173	696	11	evolution	evolution	NOUN
ecletica-1173	696	12	:	:	PUNCT
ecletica-1173	696	13	the	the	DET
ecletica-1173	696	14	conceptual	conceptual	ADJ
ecletica-1173	696	15	foundations	foundation	NOUN
ecletica-1173	696	16	of	of	ADP
ecletica-1173	696	17	evolutionary	evolutionary	ADJ
ecletica-1173	696	18	biology	biology	NOUN
ecletica-1173	696	19	;	;	PUNCT
ecletica-1173	696	20	university	university	NOUN
ecletica-1173	696	21	of	of	ADP
ecletica-1173	696	22	chicago	chicago	PROPN
ecletica-1173	696	23	press	press	NOUN
ecletica-1173	696	24	,	,	PUNCT
ecletica-1173	696	25	2010	2010	NUM
ecletica-1173	696	26	.	.	PUNCT
ecletica-1173	697	1	ponting	ponte	VERB
ecletica-1173	697	2	,	,	PUNCT
ecletica-1173	697	3	c.	c.	PROPN
ecletica-1173	697	4	p.	p.	PROPN
ecletica-1173	697	5	;	;	PUNCT
ecletica-1173	698	1	russell	russell	PROPN
ecletica-1173	698	2	,	,	PUNCT
ecletica-1173	698	3	r.	r.	PROPN
ecletica-1173	698	4	r.	r.	PROPN
ecletica-1173	698	5	the	the	DET
ecletica-1173	698	6	natural	natural	ADJ
ecletica-1173	698	7	history	history	NOUN
ecletica-1173	698	8	of	of	ADP
ecletica-1173	698	9	protein	protein	NOUN
ecletica-1173	698	10	domains	domain	NOUN
ecletica-1173	698	11	.	.	PUNCT
ecletica-1173	698	12	annu	annu	PROPN
ecletica-1173	698	13	.	.	PUNCT
ecletica-1173	699	1	rev	rev	PROPN
ecletica-1173	699	2	.	.	PROPN
ecletica-1173	699	3	biophys	biophy	NOUN
ecletica-1173	699	4	.	.	PUNCT
ecletica-1173	700	1	biomol	biomol	PROPN
ecletica-1173	700	2	.	.	PUNCT
ecletica-1173	700	3	struct	struct	NOUN
ecletica-1173	700	4	.	.	PUNCT
ecletica-1173	701	1	2002	2002	NUM
ecletica-1173	701	2	,	,	PUNCT
ecletica-1173	701	3	31	31	NUM
ecletica-1173	701	4	,	,	PUNCT
ecletica-1173	701	5	45	45	NUM
ecletica-1173	701	6	–	–	SYM
ecletica-1173	701	7	71	71	NUM
ecletica-1173	701	8	.	.	PUNCT
ecletica-1173	702	1	https://doi.org/10.1146/annurev.biophys.31.082901.134314	https://doi.org/10.1146/annurev.biophys.31.082901.134314	PROPN
ecletica-1173	702	2	.	.	PUNCT
ecletica-1173	702	3	ramasarma	ramasarma	PROPN
ecletica-1173	702	4	,	,	PUNCT
ecletica-1173	702	5	t.	t.	NOUN
ecletica-1173	702	6	one	one	NUM
ecletica-1173	702	7	protein	protein	NOUN
ecletica-1173	702	8	many	many	ADJ
ecletica-1173	702	9	functions	function	NOUN
ecletica-1173	702	10	.	.	PUNCT
ecletica-1173	703	1	curr	curr	PROPN
ecletica-1173	703	2	.	.	PUNCT
ecletica-1173	704	1	sci	sci	PROPN
ecletica-1173	704	2	.	.	PROPN
ecletica-1173	704	3	1994	1994	NUM
ecletica-1173	704	4	,	,	PUNCT
ecletica-1173	704	5	67	67	NUM
ecletica-1173	704	6	(	(	PUNCT
ecletica-1173	704	7	1	1	NUM
ecletica-1173	704	8	)	)	PUNCT
ecletica-1173	704	9	,	,	PUNCT
ecletica-1173	704	10	24	24	NUM
ecletica-1173	704	11	-	-	SYM
ecletica-1173	704	12	29	29	NUM
ecletica-1173	704	13	.	.	PUNCT
ecletica-1173	705	1	rietjens	rietjen	NOUN
ecletica-1173	705	2	,	,	PUNCT
ecletica-1173	705	3	i.	i.	PROPN
ecletica-1173	705	4	m.	m.	PROPN
ecletica-1173	705	5	c.	c.	PROPN
ecletica-1173	705	6	m.	m.	PROPN
ecletica-1173	705	7	;	;	PUNCT
ecletica-1173	705	8	boersma	boersma	PROPN
ecletica-1173	705	9	,	,	PUNCT
ecletica-1173	705	10	m.	m.	NOUN
ecletica-1173	705	11	g.	g.	PROPN
ecletica-1173	705	12	;	;	PUNCT
ecletica-1173	705	13	de	de	PROPN
ecletica-1173	705	14	haan	haan	PROPN
ecletica-1173	705	15	,	,	PUNCT
ecletica-1173	705	16	l.	l.	PROPN
ecletica-1173	705	17	;	;	PUNCT
ecletica-1173	705	18	spenkelink	spenkelink	NOUN
ecletica-1173	705	19	,	,	PUNCT
ecletica-1173	705	20	b.	b.	PROPN
ecletica-1173	705	21	;	;	PUNCT
ecletica-1173	705	22	awad	awad	PROPN
ecletica-1173	705	23	,	,	PUNCT
ecletica-1173	705	24	h.	h.	PROPN
ecletica-1173	705	25	m.	m.	NOUN
ecletica-1173	705	26	;	;	PUNCT
ecletica-1173	705	27	cnubben	cnubben	PROPN
ecletica-1173	705	28	,	,	PUNCT
ecletica-1173	705	29	n.	n.	PROPN
ecletica-1173	705	30	h.	h.	PROPN
ecletica-1173	705	31	p.	p.	PROPN
ecletica-1173	705	32	;	;	PUNCT
ecletica-1173	705	33	van	van	PROPN
ecletica-1173	705	34	zanden	zanden	PROPN
ecletica-1173	705	35	,	,	PUNCT
ecletica-1173	705	36	j.	j.	PROPN
ecletica-1173	705	37	j.	j.	PROPN
ecletica-1173	705	38	;	;	PUNCT
ecletica-1173	705	39	van	van	PROPN
ecletica-1173	705	40	der	der	PROPN
ecletica-1173	705	41	woude	woude	NOUN
ecletica-1173	705	42	,	,	PUNCT
ecletica-1173	705	43	h.	h.	PROPN
ecletica-1173	705	44	;	;	PUNCT
ecletica-1173	705	45	alink	alink	PROPN
ecletica-1173	705	46	,	,	PUNCT
ecletica-1173	705	47	g.	g.	PROPN
ecletica-1173	705	48	m.	m.	PROPN
ecletica-1173	705	49	;	;	PUNCT
ecletica-1173	705	50	koeman	koeman	PROPN
ecletica-1173	705	51	,	,	PUNCT
ecletica-1173	705	52	j.	j.	PROPN
ecletica-1173	705	53	h.	h.	PROPN
ecletica-1173	706	1	the	the	DET
ecletica-1173	706	2	pro	pro	ADJ
ecletica-1173	706	3	-	-	ADJ
ecletica-1173	706	4	oxidant	oxidant	ADJ
ecletica-1173	706	5	chemistry	chemistry	NOUN
ecletica-1173	706	6	of	of	ADP
ecletica-1173	706	7	the	the	DET
ecletica-1173	706	8	natural	natural	ADJ
ecletica-1173	706	9	antioxidants	antioxidant	NOUN
ecletica-1173	706	10	vitamin	vitamin	NOUN
ecletica-1173	706	11	c	c	NOUN
ecletica-1173	706	12	,	,	PUNCT
ecletica-1173	706	13	vitamin	vitamin	NOUN
ecletica-1173	706	14	e	e	NOUN
ecletica-1173	706	15	,	,	PUNCT
ecletica-1173	706	16	carotenoids	carotenoid	NOUN
ecletica-1173	706	17	and	and	CCONJ
ecletica-1173	706	18	flavonoids	flavonoid	NOUN
ecletica-1173	706	19	.	.	PUNCT
ecletica-1173	707	1	environ	environ	PROPN
ecletica-1173	707	2	.	.	PUNCT
ecletica-1173	708	1	toxicol	toxicol	PROPN
ecletica-1173	708	2	.	.	PUNCT
ecletica-1173	709	1	pharmacol	pharmacol	PROPN
ecletica-1173	709	2	.	.	PUNCT
ecletica-1173	710	1	2002	2002	NUM
ecletica-1173	710	2	,	,	PUNCT
ecletica-1173	710	3	11	11	NUM
ecletica-1173	710	4	(	(	PUNCT
ecletica-1173	710	5	3	3	NUM
ecletica-1173	710	6	-	-	SYM
ecletica-1173	710	7	4	4	NUM
ecletica-1173	710	8	)	)	PUNCT
ecletica-1173	710	9	,	,	PUNCT
ecletica-1173	710	10	321–333	321–333	NUM
ecletica-1173	710	11	.	.	PUNCT
ecletica-1173	711	1	https://doi.org/10.1016/s1382-6689(02)00003-0	https://doi.org/10.1016/s1382-6689(02)00003-0	PROPN
ecletica-1173	711	2	.	.	PUNCT
ecletica-1173	711	3	roothaan	roothaan	PROPN
ecletica-1173	711	4	,	,	PUNCT
ecletica-1173	711	5	c.	c.	PROPN
ecletica-1173	711	6	c.	c.	PROPN
ecletica-1173	711	7	j.	j.	PROPN
ecletica-1173	712	1	new	new	ADJ
ecletica-1173	712	2	developments	development	NOUN
ecletica-1173	712	3	in	in	ADP
ecletica-1173	712	4	molecular	molecular	ADJ
ecletica-1173	712	5	orbital	orbital	ADJ
ecletica-1173	712	6	theory	theory	NOUN
ecletica-1173	712	7	.	.	PUNCT
ecletica-1173	713	1	rev	rev	PROPN
ecletica-1173	713	2	.	.	PROPN
ecletica-1173	714	1	mod	mod	PROPN
ecletica-1173	714	2	.	.	PUNCT
ecletica-1173	715	1	phys	phy	NOUN
ecletica-1173	715	2	.	.	PUNCT
ecletica-1173	716	1	1951	1951	NUM
ecletica-1173	716	2	,	,	PUNCT
ecletica-1173	716	3	23	23	NUM
ecletica-1173	716	4	(	(	PUNCT
ecletica-1173	716	5	2	2	NUM
ecletica-1173	716	6	)	)	PUNCT
ecletica-1173	716	7	,	,	PUNCT
ecletica-1173	716	8	69–89	69–89	NUM
ecletica-1173	716	9	.	.	PUNCT
ecletica-1173	716	10	https://doi.org/10.1103/revmodphys.23.69	https://doi.org/10.1103/revmodphys.23.69	NOUN
ecletica-1173	716	11	.	.	PUNCT
ecletica-1173	717	1	ryall	ryall	PROPN
ecletica-1173	717	2	,	,	PUNCT
ecletica-1173	717	3	k.	k.	PROPN
ecletica-1173	717	4	a.	a.	PROPN
ecletica-1173	717	5	;	;	PUNCT
ecletica-1173	717	6	tan	tan	PROPN
ecletica-1173	717	7	,	,	PUNCT
ecletica-1173	717	8	a.	a.	PROPN
ecletica-1173	717	9	c.	c.	PROPN
ecletica-1173	717	10	systems	system	NOUN
ecletica-1173	717	11	biology	biology	NOUN
ecletica-1173	717	12	approaches	approach	VERB
ecletica-1173	717	13	for	for	ADP
ecletica-1173	717	14	advancing	advance	VERB
ecletica-1173	717	15	the	the	DET
ecletica-1173	717	16	discovery	discovery	NOUN
ecletica-1173	717	17	of	of	ADP
ecletica-1173	717	18	effective	effective	ADJ
ecletica-1173	717	19	drug	drug	NOUN
ecletica-1173	717	20	combinations	combination	NOUN
ecletica-1173	717	21	.	.	PUNCT
ecletica-1173	718	1	j.	j.	PROPN
ecletica-1173	718	2	cheminform	cheminform	PROPN
ecletica-1173	718	3	.	.	PUNCT
ecletica-1173	719	1	2015	2015	NUM
ecletica-1173	719	2	,	,	PUNCT
ecletica-1173	719	3	7	7	NUM
ecletica-1173	719	4	,	,	PUNCT
ecletica-1173	719	5	7	7	NUM
ecletica-1173	719	6	.	.	PUNCT
ecletica-1173	719	7	https://doi.org/10.1186/s13321-0150055-9	https://doi.org/10.1186/s13321-0150055-9	NOUN
ecletica-1173	719	8	.	.	PUNCT
ecletica-1173	720	1	schechter	schechter	NOUN
ecletica-1173	720	2	,	,	PUNCT
ecletica-1173	720	3	a.	a.	PROPN
ecletica-1173	720	4	n.	n.	PROPN
ecletica-1173	720	5	hemoglobin	hemoglobin	PROPN
ecletica-1173	720	6	research	research	NOUN
ecletica-1173	720	7	and	and	CCONJ
ecletica-1173	720	8	the	the	DET
ecletica-1173	720	9	origins	origin	NOUN
ecletica-1173	720	10	of	of	ADP
ecletica-1173	720	11	molecular	molecular	ADJ
ecletica-1173	720	12	medicine	medicine	NOUN
ecletica-1173	720	13	.	.	PUNCT
ecletica-1173	721	1	blood	blood	NOUN
ecletica-1173	721	2	2008	2008	NUM
ecletica-1173	721	3	,	,	PUNCT
ecletica-1173	721	4	112	112	NUM
ecletica-1173	721	5	(	(	PUNCT
ecletica-1173	721	6	10	10	NUM
ecletica-1173	721	7	)	)	PUNCT
ecletica-1173	721	8	,	,	PUNCT
ecletica-1173	721	9	3927–3938	3927–3938	NUM
ecletica-1173	721	10	.	.	PUNCT
ecletica-1173	722	1	https://doi.org/10.1182/blood-2008-04-078188	https://doi.org/10.1182/blood-2008-04-078188	NOUN
ecletica-1173	722	2	.	.	PUNCT
ecletica-1173	723	1	schrödinger	schrödinger	PROPN
ecletica-1173	723	2	,	,	PUNCT
ecletica-1173	723	3	e.	e.	PROPN
ecletica-1173	723	4	an	an	DET
ecletica-1173	723	5	undulatory	undulatory	NOUN
ecletica-1173	723	6	theory	theory	NOUN
ecletica-1173	723	7	of	of	ADP
ecletica-1173	723	8	the	the	DET
ecletica-1173	723	9	mechanics	mechanic	NOUN
ecletica-1173	723	10	of	of	ADP
ecletica-1173	723	11	atoms	atom	NOUN
ecletica-1173	723	12	and	and	CCONJ
ecletica-1173	723	13	molecules	molecule	NOUN
ecletica-1173	723	14	.	.	PUNCT
ecletica-1173	724	1	phys	phy	NOUN
ecletica-1173	724	2	.	.	PUNCT
ecletica-1173	725	1	rev	rev	PROPN
ecletica-1173	725	2	.	.	PROPN
ecletica-1173	725	3	1926	1926	NUM
ecletica-1173	725	4	,	,	PUNCT
ecletica-1173	725	5	28(6	28(6	NUM
ecletica-1173	725	6	)	)	PUNCT
ecletica-1173	725	7	,	,	PUNCT
ecletica-1173	725	8	1049–1070	1049–1070	NUM
ecletica-1173	725	9	.	.	PUNCT
ecletica-1173	726	1	https://doi.org/10.1103/physrev.28.1049	https://doi.org/10.1103/physrev.28.1049	PROPN
ecletica-1173	726	2	.	.	PUNCT
ecletica-1173	726	3	schrödinger	schrödinger	PROPN
ecletica-1173	726	4	,	,	PUNCT
ecletica-1173	726	5	e.	e.	PROPN
ecletica-1173	726	6	what	what	PRON
ecletica-1173	726	7	is	be	AUX
ecletica-1173	726	8	life	life	NOUN
ecletica-1173	726	9	?	?	PUNCT
ecletica-1173	727	1	j.	j.	PROPN
ecletica-1173	727	2	philos	philos	PROPN
ecletica-1173	727	3	.	.	PUNCT
ecletica-1173	728	1	1946	1946	NUM
ecletica-1173	728	2	,	,	PUNCT
ecletica-1173	728	3	43	43	NUM
ecletica-1173	728	4	(	(	PUNCT
ecletica-1173	728	5	7	7	NUM
ecletica-1173	728	6	)	)	PUNCT
ecletica-1173	728	7	,	,	PUNCT
ecletica-1173	728	8	194195	194195	NUM
ecletica-1173	728	9	.	.	PUNCT
ecletica-1173	729	1	https://doi.org/10.2307/2019342	https://doi.org/10.2307/2019342	X
ecletica-1173	729	2	.	.	PUNCT
ecletica-1173	730	1	shah	shah	NOUN
ecletica-1173	730	2	,	,	PUNCT
ecletica-1173	730	3	p.	p.	NOUN
ecletica-1173	730	4	;	;	PUNCT
ecletica-1173	730	5	dylgjeri	dylgjeri	PROPN
ecletica-1173	730	6	,	,	PUNCT
ecletica-1173	730	7	f.	f.	PROPN
ecletica-1173	730	8	;	;	PUNCT
ecletica-1173	730	9	srinivasan	srinivasan	PROPN
ecletica-1173	730	10	,	,	PUNCT
ecletica-1173	730	11	b.	b.	PROPN
ecletica-1173	730	12	;	;	PUNCT
ecletica-1173	730	13	brennan	brennan	PROPN
ecletica-1173	730	14	,	,	PUNCT
ecletica-1173	731	1	p.	p.	NOUN
ecletica-1173	731	2	a.	a.	PROPN
ecletica-1173	731	3	oral	oral	PROPN
ecletica-1173	731	4	tyrosine	tyrosine	PROPN
ecletica-1173	731	5	kinase	kinase	PROPN
ecletica-1173	731	6	inhibitors	inhibitor	NOUN
ecletica-1173	731	7	in	in	ADP
ecletica-1173	731	8	omfs	omfs	PROPN
ecletica-1173	731	9	:	:	PUNCT
ecletica-1173	731	10	a	a	DET
ecletica-1173	731	11	review	review	NOUN
ecletica-1173	731	12	.	.	PUNCT
ecletica-1173	732	1	j.	j.	PROPN
ecletica-1173	732	2	oral	oral	PROPN
ecletica-1173	732	3	maxillofac	maxillofac	NOUN
ecletica-1173	732	4	.	.	PUNCT
ecletica-1173	733	1	surg	surg	NOUN
ecletica-1173	733	2	.	.	PUNCT
ecletica-1173	734	1	2020	2020	NUM
ecletica-1173	734	2	,	,	PUNCT
ecletica-1173	734	3	58	58	NUM
ecletica-1173	734	4	(	(	PUNCT
ecletica-1173	734	5	2	2	NUM
ecletica-1173	734	6	)	)	PUNCT
ecletica-1173	734	7	,	,	PUNCT
ecletica-1173	734	8	135–138	135–138	NUM
ecletica-1173	734	9	.	.	PUNCT
ecletica-1173	735	1	https://doi.org/10.1016/j.bjoms.2019.11.022	https://doi.org/10.1016/j.bjoms.2019.11.022	PROPN
ecletica-1173	735	2	.	.	PROPN
ecletica-1173	735	3	shavitt	shavitt	PROPN
ecletica-1173	735	4	,	,	PUNCT
ecletica-1173	735	5	i.	i.	PROPN
ecletica-1173	735	6	;	;	PUNCT
ecletica-1173	735	7	bartlett	bartlett	PROPN
ecletica-1173	735	8	,	,	PUNCT
ecletica-1173	735	9	r.	r.	PROPN
ecletica-1173	735	10	j.	j.	PROPN
ecletica-1173	735	11	many	many	ADJ
ecletica-1173	735	12	-	-	PUNCT
ecletica-1173	735	13	body	body	NOUN
ecletica-1173	735	14	methods	method	NOUN
ecletica-1173	735	15	in	in	ADP
ecletica-1173	735	16	chemistry	chemistry	NOUN
ecletica-1173	735	17	and	and	CCONJ
ecletica-1173	735	18	physics	physics	NOUN
ecletica-1173	735	19	:	:	PUNCT
ecletica-1173	735	20	mbpt	mbpt	PROPN
ecletica-1173	735	21	and	and	CCONJ
ecletica-1173	735	22	coupled	couple	VERB
ecletica-1173	735	23	-	-	PUNCT
ecletica-1173	735	24	cluster	cluster	NOUN
ecletica-1173	735	25	theory	theory	NOUN
ecletica-1173	735	26	;	;	PUNCT
ecletica-1173	735	27	cambridge	cambridge	PROPN
ecletica-1173	735	28	university	university	PROPN
ecletica-1173	735	29	press	press	NOUN
ecletica-1173	735	30	,	,	PUNCT
ecletica-1173	735	31	2009	2009	NUM
ecletica-1173	735	32	.	.	PUNCT
ecletica-1173	736	1	https://doi.org/10.1017/cbo9780511596834	https://doi.org/10.1017/cbo9780511596834	PROPN
ecletica-1173	736	2	.	.	PUNCT
ecletica-1173	737	1	sobie	sobie	PROPN
ecletica-1173	737	2	,	,	PUNCT
ecletica-1173	737	3	e.	e.	PROPN
ecletica-1173	737	4	a.	a.	PROPN
ecletica-1173	737	5	;	;	PUNCT
ecletica-1173	737	6	lee	lee	PROPN
ecletica-1173	737	7	,	,	PUNCT
ecletica-1173	737	8	y.-s	y.-	NOUN
ecletica-1173	737	9	.	.	PUNCT
ecletica-1173	737	10	;	;	PUNCT
ecletica-1173	737	11	jenkins	jenkins	PROPN
ecletica-1173	737	12	,	,	PUNCT
ecletica-1173	737	13	s.	s.	PROPN
ecletica-1173	737	14	l.	l.	PROPN
ecletica-1173	737	15	;	;	PUNCT
ecletica-1173	737	16	iyengar	iyengar	PROPN
ecletica-1173	737	17	,	,	PUNCT
ecletica-1173	737	18	r.	r.	PROPN
ecletica-1173	737	19	systems	systems	PROPN
ecletica-1173	737	20	biology	biology	NOUN
ecletica-1173	737	21	—	—	PUNCT
ecletica-1173	737	22	biomedical	biomedical	ADJ
ecletica-1173	737	23	modeling	modeling	NOUN
ecletica-1173	737	24	.	.	PUNCT
ecletica-1173	738	1	sci	sci	PROPN
ecletica-1173	738	2	.	.	PROPN
ecletica-1173	738	3	signal	signal	PROPN
ecletica-1173	738	4	2011	2011	NUM
ecletica-1173	738	5	,	,	PUNCT
ecletica-1173	738	6	4	4	NUM
ecletica-1173	738	7	(	(	PUNCT
ecletica-1173	738	8	190	190	NUM
ecletica-1173	738	9	)	)	PUNCT
ecletica-1173	738	10	,	,	PUNCT
ecletica-1173	739	1	tr2	tr2	X
ecletica-1173	739	2	.	.	PUNCT
ecletica-1173	739	3	https://doi.org/10.1126/scisignal.2001989	https://doi.org/10.1126/scisignal.2001989	PROPN
ecletica-1173	739	4	.	.	PUNCT
ecletica-1173	740	1	sonnenschein	sonnenschein	PROPN
ecletica-1173	740	2	,	,	PUNCT
ecletica-1173	740	3	c.	c.	PROPN
ecletica-1173	740	4	;	;	PUNCT
ecletica-1173	740	5	soto	soto	PROPN
ecletica-1173	740	6	,	,	PUNCT
ecletica-1173	740	7	a.	a.	NOUN
ecletica-1173	740	8	m.	m.	NOUN
ecletica-1173	740	9	over	over	ADP
ecletica-1173	740	10	a	a	DET
ecletica-1173	740	11	century	century	NOUN
ecletica-1173	740	12	of	of	ADP
ecletica-1173	740	13	cancer	cancer	NOUN
ecletica-1173	740	14	research	research	NOUN
ecletica-1173	740	15	:	:	PUNCT
ecletica-1173	740	16	inconvenient	inconvenient	ADJ
ecletica-1173	740	17	truths	truth	NOUN
ecletica-1173	740	18	and	and	CCONJ
ecletica-1173	740	19	promising	promising	ADJ
ecletica-1173	740	20	leads	lead	NOUN
ecletica-1173	740	21	.	.	PUNCT
ecletica-1173	741	1	plos	plos	PROPN
ecletica-1173	741	2	biol	biol	PROPN
ecletica-1173	741	3	.	.	PUNCT
ecletica-1173	742	1	2020	2020	NUM
ecletica-1173	742	2	,	,	PUNCT
ecletica-1173	742	3	18	18	NUM
ecletica-1173	742	4	(	(	PUNCT
ecletica-1173	742	5	4	4	NUM
ecletica-1173	742	6	)	)	PUNCT
ecletica-1173	742	7	,	,	PUNCT
ecletica-1173	742	8	e3000670	e3000670	NOUN
ecletica-1173	742	9	.	.	PUNCT
ecletica-1173	743	1	https://doi.org/10.1371/journal.pbio.3000670	https://doi.org/10.1371/journal.pbio.3000670	PROPN
ecletica-1173	743	2	.	.	PUNCT
ecletica-1173	744	1	soto	soto	PROPN
ecletica-1173	744	2	,	,	PUNCT
ecletica-1173	744	3	a.	a.	NOUN
ecletica-1173	744	4	m.	m.	NOUN
ecletica-1173	744	5	;	;	PUNCT
ecletica-1173	744	6	sonnenschein	sonnenschein	PROPN
ecletica-1173	744	7	,	,	PUNCT
ecletica-1173	744	8	c.	c.	PROPN
ecletica-1173	744	9	emergentism	emergentism	NOUN
ecletica-1173	744	10	as	as	ADP
ecletica-1173	744	11	a	a	DET
ecletica-1173	744	12	default	default	NOUN
ecletica-1173	744	13	:	:	PUNCT
ecletica-1173	744	14	cancer	cancer	NOUN
ecletica-1173	744	15	as	as	ADP
ecletica-1173	744	16	a	a	DET
ecletica-1173	744	17	problem	problem	NOUN
ecletica-1173	744	18	of	of	ADP
ecletica-1173	744	19	tissue	tissue	NOUN
ecletica-1173	744	20	organization	organization	NOUN
ecletica-1173	744	21	.	.	PUNCT
ecletica-1173	745	1	j.	j.	PROPN
ecletica-1173	745	2	biosci	biosci	PROPN
ecletica-1173	745	3	.	.	PUNCT
ecletica-1173	746	1	2005	2005	NUM
ecletica-1173	746	2	,	,	PUNCT
ecletica-1173	746	3	30	30	NUM
ecletica-1173	746	4	(	(	PUNCT
ecletica-1173	746	5	1	1	NUM
ecletica-1173	746	6	)	)	PUNCT
ecletica-1173	746	7	,	,	PUNCT
ecletica-1173	746	8	103–118	103–118	NUM
ecletica-1173	746	9	.	.	PUNCT
ecletica-1173	747	1	https://doi.org/10.1007/bf02705155	https://doi.org/10.1007/bf02705155	PROPN
ecletica-1173	747	2	.	.	PUNCT
ecletica-1173	748	1	http://revista.iq.unesp.br/ojs/index.php/ecletica/index	http://revista.iq.unesp.br/ojs/index.php/ecletica/index	NOUN
ecletica-1173	748	2	https://doi.org/10.26850/1678-4618eqj.v46.3.2021.p17-32	https://doi.org/10.26850/1678-4618eqj.v46.3.2021.p17-32	PROPN
ecletica-1173	748	3	https://doi.org/10.1021/acsomega.8b02364	https://doi.org/10.1021/acsomega.8b02364	ADV
ecletica-1173	748	4	https://doi.org/10.1021/acsomega.8b02364	https://doi.org/10.1021/acsomega.8b02364	ADV
ecletica-1173	748	5	https://doi.org/10.1021/acsomega.8b02364	https://doi.org/10.1021/acsomega.8b02364	ADV
ecletica-1173	748	6	https://doi.org/10.1021/acsomega.8b02364	https://doi.org/10.1021/acsomega.8b02364	ADV
ecletica-1173	748	7	https://doi.org/10.1021/acsomega.8b02364	https://doi.org/10.1021/acsomega.8b02364	PROPN
ecletica-1173	748	8	https://www.cancer.gov/	https://www.cancer.gov/	PROPN
ecletica-1173	748	9	https://www.cancer.gov/	https://www.cancer.gov/	PROPN
ecletica-1173	749	1	https://doi.org/10.1016/j.jtbi.2019.06.002	https://doi.org/10.1016/j.jtbi.2019.06.002	NOUN
ecletica-1173	749	2	https://doi.org/10.1016/j.jtbi.2019.06.002	https://doi.org/10.1016/j.jtbi.2019.06.002	NOUN
ecletica-1173	749	3	https://doi.org/10.1016/j.jtbi.2019.06.002	https://doi.org/10.1016/j.jtbi.2019.06.002	NOUN
ecletica-1173	749	4	https://doi.org/10.1038/42600	https://doi.org/10.1038/42600	NOUN
ecletica-1173	749	5	https://doi.org/10.1038/42600	https://doi.org/10.1038/42600	NOUN
ecletica-1173	749	6	https://doi.org/10.1080/10408398.2017.1348335	https://doi.org/10.1080/10408398.2017.1348335	PUNCT
ecletica-1173	749	7	https://doi.org/10.1080/10408398.2017.1348335	https://doi.org/10.1080/10408398.2017.1348335	NOUN
ecletica-1173	749	8	https://doi.org/10.1080/10408398.2017.1348335	https://doi.org/10.1080/10408398.2017.1348335	PUNCT
ecletica-1173	749	9	https://doi.org/10.1080/10408398.2017.1348335	https://doi.org/10.1080/10408398.2017.1348335	PUNCT
ecletica-1173	749	10	https://doi.org/10.1080/10408398.2017.1348335	https://doi.org/10.1080/10408398.2017.1348335	PUNCT
ecletica-1173	750	1	https://doi.org/10.1080/10408398.2017.1348335	https://doi.org/10.1080/10408398.2017.1348335	NOUN
ecletica-1173	751	1	https://doi.org/10.1093/jnci/88.21.1550	https://doi.org/10.1093/jnci/88.21.1550	PRON
ecletica-1173	751	2	https://doi.org/10.1093/jnci/88.21.1550	https://doi.org/10.1093/jnci/88.21.1550	PROPN
ecletica-1173	751	3	https://doi.org/10.1093/jnci/88.21.1550	https://doi.org/10.1093/jnci/88.21.1550	PROPN
ecletica-1173	751	4	https://doi.org/10.1093/jnci/88.21.1550	https://doi.org/10.1093/jnci/88.21.1550	PROPN
ecletica-1173	751	5	https://doi.org/10.1093/jnci/88.21.1550	https://doi.org/10.1093/jnci/88.21.1550	PROPN
ecletica-1173	751	6	https://doi.org/10.1093/jnci/88.21.1550	https://doi.org/10.1093/jnci/88.21.1550	PROPN
ecletica-1173	751	7	https://doi.org/10.1093/jnci/88.21.1550	https://doi.org/10.1093/jnci/88.21.1550	PROPN
ecletica-1173	751	8	https://doi.org/10.1093/jnci/88.21.1550	https://doi.org/10.1093/jnci/88.21.1550	PROPN
ecletica-1173	751	9	https://doi.org/10.1142/9789814366496_0034	https://doi.org/10.1142/9789814366496_0034	PROPN
ecletica-1173	751	10	https://doi.org/10.1142/9789814366496_0034	https://doi.org/10.1142/9789814366496_0034	PROPN
ecletica-1173	751	11	https://doi.org/10.1142/9789814366496_0034	https://doi.org/10.1142/9789814366496_0034	X
ecletica-1173	751	12	https://doi.org/10.1142/9789814366496_0034	https://doi.org/10.1142/9789814366496_0034	X
ecletica-1173	751	13	https://doi.org/10.1021/cr950066q	https://doi.org/10.1021/cr950066q	X
ecletica-1173	751	14	https://doi.org/10.1021/cr950066q	https://doi.org/10.1021/cr950066q	X
ecletica-1173	751	15	https://doi.org/10.1021/cr950066q	https://doi.org/10.1021/cr950066q	X
ecletica-1173	752	1	https://doi.org/10.1038/nchembio1108-635	https://doi.org/10.1038/nchembio1108-635	PROPN
ecletica-1173	752	2	https://doi.org/10.1038/nchembio1108-635	https://doi.org/10.1038/nchembio1108-635	PROPN
ecletica-1173	752	3	https://doi.org/10.1038/nchembio1108-635	https://doi.org/10.1038/nchembio1108-635	PROPN
ecletica-1173	752	4	https://doi.org/10.1042/bsr20181958	https://doi.org/10.1042/bsr20181958	VERB
ecletica-1173	752	5	https://doi.org/10.1042/bsr20181958	https://doi.org/10.1042/bsr20181958	VERB
ecletica-1173	752	6	https://doi.org/10.1042/bsr20181958	https://doi.org/10.1042/bsr20181958	VERB
ecletica-1173	752	7	https://doi.org/10.1042/bsr20181958	https://doi.org/10.1042/bsr20181958	X
ecletica-1173	752	8	https://doi.org/10.1042/bsr20181958	https://doi.org/10.1042/bsr20181958	VERB
ecletica-1173	752	9	https://doi.org/10.1146/annurev.biophys.31.082901.134314	https://doi.org/10.1146/annurev.biophys.31.082901.134314	NOUN
ecletica-1173	752	10	https://doi.org/10.1146/annurev.biophys.31.082901.134314	https://doi.org/10.1146/annurev.biophys.31.082901.134314	NOUN
ecletica-1173	752	11	https://doi.org/10.1146/annurev.biophys.31.082901.134314	https://doi.org/10.1146/annurev.biophys.31.082901.134314	PROPN
ecletica-1173	752	12	https://doi.org/10.1146/annurev.biophys.31.082901.134314	https://doi.org/10.1146/annurev.biophys.31.082901.134314	PROPN
ecletica-1173	752	13	https://doi.org/10.1016/s1382-6689(02)00003-0	https://doi.org/10.1016/s1382-6689(02)00003-0	NOUN
ecletica-1173	752	14	https://doi.org/10.1016/s1382-6689(02)00003-0	https://doi.org/10.1016/s1382-6689(02)00003-0	NOUN
ecletica-1173	752	15	https://doi.org/10.1016/s1382-6689(02)00003-0	https://doi.org/10.1016/s1382-6689(02)00003-0	NOUN
ecletica-1173	752	16	https://doi.org/10.1016/s1382-6689(02)00003-0	https://doi.org/10.1016/s1382-6689(02)00003-0	NOUN
ecletica-1173	752	17	https://doi.org/10.1016/s1382-6689(02)00003-0	https://doi.org/10.1016/s1382-6689(02)00003-0	NOUN
ecletica-1173	752	18	https://doi.org/10.1016/s1382-6689(02)00003-0	https://doi.org/10.1016/s1382-6689(02)00003-0	NOUN
ecletica-1173	752	19	https://doi.org/10.1016/s1382-6689(02)00003-0	https://doi.org/10.1016/s1382-6689(02)00003-0	NOUN
ecletica-1173	752	20	https://doi.org/10.1103/revmodphys.23.69	https://doi.org/10.1103/revmodphys.23.69	NOUN
ecletica-1173	752	21	https://doi.org/10.1103/revmodphys.23.69	https://doi.org/10.1103/revmodphys.23.69	NOUN
ecletica-1173	752	22	https://doi.org/10.1103/revmodphys.23.69	https://doi.org/10.1103/revmodphys.23.69	NOUN
ecletica-1173	752	23	https://doi.org/10.1186/s13321-015-0055-9	https://doi.org/10.1186/s13321-015-0055-9	NUM
ecletica-1173	752	24	https://doi.org/10.1186/s13321-015-0055-9	https://doi.org/10.1186/s13321-015-0055-9	NUM
ecletica-1173	752	25	https://doi.org/10.1186/s13321-015-0055-9	https://doi.org/10.1186/s13321-015-0055-9	NUM
ecletica-1173	752	26	https://doi.org/10.1186/s13321-015-0055-9	https://doi.org/10.1186/s13321-015-0055-9	NUM
ecletica-1173	753	1	https://doi.org/10.1182/blood-2008-04-078188	https://doi.org/10.1182/blood-2008-04-078188	NUM
ecletica-1173	753	2	https://doi.org/10.1182/blood-2008-04-078188	https://doi.org/10.1182/blood-2008-04-078188	NUM
ecletica-1173	753	3	https://doi.org/10.1182/blood-2008-04-078188	https://doi.org/10.1182/blood-2008-04-078188	NUM
ecletica-1173	753	4	https://doi.org/10.1103/physrev.28.1049	https://doi.org/10.1103/physrev.28.1049	INTJ
ecletica-1173	753	5	https://doi.org/10.1103/physrev.28.1049	https://doi.org/10.1103/physrev.28.1049	PROPN
ecletica-1173	753	6	https://doi.org/10.1103/physrev.28.1049	https://doi.org/10.1103/physrev.28.1049	PROPN
ecletica-1173	753	7	https://doi.org/10.2307/2019342	https://doi.org/10.2307/2019342	PROPN
ecletica-1173	753	8	https://doi.org/10.2307/2019342	https://doi.org/10.2307/2019342	PROPN
ecletica-1173	753	9	https://doi.org/10.1016/j.bjoms.2019.11.022	https://doi.org/10.1016/j.bjoms.2019.11.022	NOUN
ecletica-1173	753	10	https://doi.org/10.1016/j.bjoms.2019.11.022	https://doi.org/10.1016/j.bjoms.2019.11.022	PROPN
ecletica-1173	753	11	https://doi.org/10.1016/j.bjoms.2019.11.022	https://doi.org/10.1016/j.bjoms.2019.11.022	PROPN
ecletica-1173	753	12	https://doi.org/10.1016/j.bjoms.2019.11.022	https://doi.org/10.1016/j.bjoms.2019.11.022	PROPN
ecletica-1173	753	13	https://doi.org/10.1017/cbo9780511596834	https://doi.org/10.1017/cbo9780511596834	PROPN
ecletica-1173	753	14	https://doi.org/10.1017/cbo9780511596834	https://doi.org/10.1017/cbo9780511596834	PROPN
ecletica-1173	753	15	https://doi.org/10.1017/cbo9780511596834	https://doi.org/10.1017/cbo9780511596834	PROPN
ecletica-1173	753	16	https://doi.org/10.1017/cbo9780511596834	https://doi.org/10.1017/cbo9780511596834	NOUN
ecletica-1173	753	17	https://doi.org/10.1126/scisignal.2001989	https://doi.org/10.1126/scisignal.2001989	NOUN
ecletica-1173	753	18	https://doi.org/10.1126/scisignal.2001989	https://doi.org/10.1126/scisignal.2001989	PRON
ecletica-1173	753	19	https://doi.org/10.1126/scisignal.2001989	https://doi.org/10.1126/scisignal.2001989	PROPN
ecletica-1173	754	1	https://doi.org/10.1371/journal.pbio.3000670	https://doi.org/10.1371/journal.pbio.3000670	PROPN
ecletica-1173	754	2	https://doi.org/10.1371/journal.pbio.3000670	https://doi.org/10.1371/journal.pbio.3000670	PROPN
ecletica-1173	754	3	https://doi.org/10.1371/journal.pbio.3000670	https://doi.org/10.1371/journal.pbio.3000670	PROPN
ecletica-1173	754	4	https://doi.org/10.1371/journal.pbio.3000670	https://doi.org/10.1371/journal.pbio.3000670	PROPN
ecletica-1173	755	1	https://doi.org/10.1007/bf02705155	https://doi.org/10.1007/bf02705155	NOUN
ecletica-1173	755	2	https://doi.org/10.1007/bf02705155	https://doi.org/10.1007/bf02705155	NOUN
ecletica-1173	755	3	https://doi.org/10.1007/bf02705155	https://doi.org/10.1007/bf02705155	AUX
ecletica-1173	755	4	review	review	VERB
ecletica-1173	755	5	article	article	NOUN
ecletica-1173	755	6	iq.unesp.br/ecletica	iq.unesp.br/ecletica	PROPN
ecletica-1173	755	7	32	32	NUM
ecletica-1173	755	8	eclética	eclética	PROPN
ecletica-1173	755	9	química	química	PROPN
ecletica-1173	755	10	journal	journal	PROPN
ecletica-1173	755	11	,	,	PUNCT
ecletica-1173	755	12	vol	vol	NOUN
ecletica-1173	755	13	.	.	PROPN
ecletica-1173	755	14	46	46	NUM
ecletica-1173	755	15	,	,	PUNCT
ecletica-1173	755	16	n.	n.	NOUN
ecletica-1173	755	17	3	3	NUM
ecletica-1173	755	18	,	,	PUNCT
ecletica-1173	755	19	2021	2021	NUM
ecletica-1173	755	20	,	,	PUNCT
ecletica-1173	755	21	17	17	NUM
ecletica-1173	755	22	-	-	SYM
ecletica-1173	755	23	32	32	NUM
ecletica-1173	755	24	issn	issn	NOUN
ecletica-1173	755	25	:	:	PUNCT
ecletica-1173	755	26	1678	1678	NUM
ecletica-1173	755	27	-	-	SYM
ecletica-1173	755	28	4618	4618	NUM
ecletica-1173	755	29	doi	doi	NOUN
ecletica-1173	755	30	:	:	PUNCT
ecletica-1173	755	31	10.26850/1678	10.26850/1678	NUM
ecletica-1173	755	32	-	-	SYM
ecletica-1173	755	33	4618eqj.v46.3.2021.p17	4618eqj.v46.3.2021.p17	NOUN
ecletica-1173	755	34	-	-	PUNCT
ecletica-1173	755	35	32	32	NUM
ecletica-1173	755	36	van	van	PROPN
ecletica-1173	755	37	der	der	PROPN
ecletica-1173	755	38	spoel	spoel	PROPN
ecletica-1173	755	39	,	,	PUNCT
ecletica-1173	755	40	d.	d.	PROPN
ecletica-1173	755	41	systematic	systematic	PROPN
ecletica-1173	755	42	design	design	NOUN
ecletica-1173	755	43	of	of	ADP
ecletica-1173	755	44	biomolecular	biomolecular	ADJ
ecletica-1173	755	45	force	force	NOUN
ecletica-1173	755	46	fields	field	NOUN
ecletica-1173	755	47	.	.	PUNCT
ecletica-1173	756	1	curr	curr	PROPN
ecletica-1173	756	2	.	.	PUNCT
ecletica-1173	757	1	opin	opin	NOUN
ecletica-1173	757	2	.	.	PUNCT
ecletica-1173	757	3	struct	struct	NOUN
ecletica-1173	757	4	.	.	PUNCT
ecletica-1173	758	1	biol	biol	PROPN
ecletica-1173	758	2	.	.	PUNCT
ecletica-1173	759	1	2021	2021	NUM
ecletica-1173	759	2	,	,	PUNCT
ecletica-1173	759	3	67	67	NUM
ecletica-1173	759	4	,	,	PUNCT
ecletica-1173	759	5	18	18	NUM
ecletica-1173	759	6	-	-	SYM
ecletica-1173	759	7	24	24	NUM
ecletica-1173	759	8	.	.	PUNCT
ecletica-1173	760	1	https://doi.org/10.1016/j.sbi.2020.08.006	https://doi.org/10.1016/j.sbi.2020.08.006	PROPN
ecletica-1173	760	2	.	.	PUNCT
ecletica-1173	761	1	van	van	PROPN
ecletica-1173	761	2	ommen	ommen	PROPN
ecletica-1173	761	3	,	,	PUNCT
ecletica-1173	761	4	b.	b.	PROPN
ecletica-1173	761	5	;	;	PUNCT
ecletica-1173	761	6	cavallieri	cavallieri	PROPN
ecletica-1173	761	7	,	,	PUNCT
ecletica-1173	761	8	d.	d.	PROPN
ecletica-1173	761	9	;	;	PUNCT
ecletica-1173	761	10	roche	roche	PROPN
ecletica-1173	761	11	,	,	PUNCT
ecletica-1173	761	12	h.	h.	PROPN
ecletica-1173	761	13	m.	m.	PROPN
ecletica-1173	761	14	;	;	PUNCT
ecletica-1173	761	15	klein	klein	PROPN
ecletica-1173	761	16	,	,	PUNCT
ecletica-1173	761	17	u.	u.	PROPN
ecletica-1173	761	18	i.	i.	PROPN
ecletica-1173	761	19	;	;	PUNCT
ecletica-1173	761	20	daniel	daniel	PROPN
ecletica-1173	761	21	,	,	PUNCT
ecletica-1173	761	22	h.	h.	PROPN
ecletica-1173	761	23	the	the	DET
ecletica-1173	761	24	challenges	challenge	NOUN
ecletica-1173	761	25	for	for	ADP
ecletica-1173	761	26	molecular	molecular	ADJ
ecletica-1173	761	27	nutrition	nutrition	NOUN
ecletica-1173	761	28	research	research	NOUN
ecletica-1173	761	29	4	4	NUM
ecletica-1173	761	30	:	:	PUNCT
ecletica-1173	761	31	the	the	DET
ecletica-1173	761	32	“	"	PUNCT
ecletica-1173	761	33	nutritional	nutritional	ADJ
ecletica-1173	761	34	systems	system	NOUN
ecletica-1173	761	35	biology	biology	NOUN
ecletica-1173	761	36	level	level	NOUN
ecletica-1173	761	37	”	"	PUNCT
ecletica-1173	761	38	.	.	PUNCT
ecletica-1173	762	1	genes	gene	NOUN
ecletica-1173	762	2	nutr	nutr	PROPN
ecletica-1173	762	3	.	.	PROPN
ecletica-1173	762	4	2008	2008	NUM
ecletica-1173	762	5	,	,	PUNCT
ecletica-1173	762	6	3	3	NUM
ecletica-1173	762	7	,	,	PUNCT
ecletica-1173	762	8	107–113	107–113	NUM
ecletica-1173	762	9	.	.	PUNCT
ecletica-1173	763	1	https://doi.org/10.1007/s12263-008-0090-5	https://doi.org/10.1007/s12263-008-0090-5	NOUN
ecletica-1173	763	2	.	.	PUNCT
ecletica-1173	764	1	van	van	PROPN
ecletica-1173	764	2	regenmortel	regenmortel	PROPN
ecletica-1173	764	3	,	,	PUNCT
ecletica-1173	764	4	m.	m.	NOUN
ecletica-1173	764	5	h.	h.	PROPN
ecletica-1173	765	1	v.	v.	PROPN
ecletica-1173	765	2	are	be	AUX
ecletica-1173	765	3	there	there	PRON
ecletica-1173	765	4	two	two	NUM
ecletica-1173	765	5	distinct	distinct	ADJ
ecletica-1173	765	6	research	research	NOUN
ecletica-1173	765	7	strategies	strategy	NOUN
ecletica-1173	765	8	for	for	ADP
ecletica-1173	765	9	developing	develop	VERB
ecletica-1173	765	10	biologically	biologically	ADV
ecletica-1173	765	11	active	active	ADJ
ecletica-1173	765	12	molecules	molecule	NOUN
ecletica-1173	765	13	:	:	PUNCT
ecletica-1173	765	14	rational	rational	ADJ
ecletica-1173	765	15	design	design	NOUN
ecletica-1173	765	16	and	and	CCONJ
ecletica-1173	765	17	empirical	empirical	ADJ
ecletica-1173	765	18	selection	selection	NOUN
ecletica-1173	765	19	?	?	PUNCT
ecletica-1173	766	1	j.	j.	PROPN
ecletica-1173	766	2	mol	mol	PROPN
ecletica-1173	766	3	.	.	PROPN
ecletica-1173	767	1	recognit	recognit	PROPN
ecletica-1173	767	2	.	.	PROPN
ecletica-1173	768	1	2000	2000	NUM
ecletica-1173	768	2	,	,	PUNCT
ecletica-1173	768	3	13	13	NUM
ecletica-1173	768	4	(	(	PUNCT
ecletica-1173	768	5	1	1	NUM
ecletica-1173	768	6	)	)	PUNCT
ecletica-1173	768	7	,	,	PUNCT
ecletica-1173	768	8	1–4	1–4	PROPN
ecletica-1173	768	9	.	.	PUNCT
ecletica-1173	769	1	https://doi.org/10.1002/(sici)10991352(200001/02)13:1%3c1::aid-jmr490%3e3.0.co;2-w	https://doi.org/10.1002/(sici)10991352(200001/02)13:1%3c1::aid-jmr490%3e3.0.co;2-w	PROPN
ecletica-1173	769	2	.	.	PUNCT
ecletica-1173	770	1	van	van	PROPN
ecletica-1173	770	2	regenmortel	regenmortel	PROPN
ecletica-1173	770	3	,	,	PUNCT
ecletica-1173	770	4	m.	m.	NOUN
ecletica-1173	770	5	h.	h.	PROPN
ecletica-1173	771	1	v.	v.	ADP
ecletica-1173	771	2	pitfalls	pitfall	NOUN
ecletica-1173	771	3	of	of	ADP
ecletica-1173	771	4	reductionism	reductionism	NOUN
ecletica-1173	771	5	in	in	ADP
ecletica-1173	771	6	the	the	DET
ecletica-1173	771	7	design	design	NOUN
ecletica-1173	771	8	of	of	ADP
ecletica-1173	771	9	peptide	peptide	NOUN
ecletica-1173	771	10	-	-	PUNCT
ecletica-1173	771	11	based	base	VERB
ecletica-1173	771	12	vaccines	vaccine	NOUN
ecletica-1173	771	13	.	.	PUNCT
ecletica-1173	772	1	vaccine	vaccine	NOUN
ecletica-1173	772	2	2001	2001	NUM
ecletica-1173	772	3	,	,	PUNCT
ecletica-1173	772	4	19	19	NUM
ecletica-1173	772	5	(	(	PUNCT
ecletica-1173	772	6	17–19	17–19	NUM
ecletica-1173	772	7	)	)	PUNCT
ecletica-1173	772	8	,	,	PUNCT
ecletica-1173	772	9	2369	2369	NUM
ecletica-1173	772	10	-	-	SYM
ecletica-1173	772	11	2374	2374	NUM
ecletica-1173	772	12	.	.	PUNCT
ecletica-1173	773	1	https://doi.org/10.1016/s0264-410x(00)004564	https://doi.org/10.1016/s0264-410x(00)004564	PROPN
ecletica-1173	773	2	.	.	PUNCT
ecletica-1173	774	1	van	van	PROPN
ecletica-1173	774	2	regenmortel	regenmortel	PROPN
ecletica-1173	774	3	,	,	PUNCT
ecletica-1173	774	4	m.	m.	NOUN
ecletica-1173	774	5	h.	h.	PROPN
ecletica-1173	775	1	v.	v.	CCONJ
ecletica-1173	775	2	reductionism	reductionism	NOUN
ecletica-1173	775	3	and	and	CCONJ
ecletica-1173	775	4	complexity	complexity	NOUN
ecletica-1173	775	5	in	in	ADP
ecletica-1173	775	6	molecular	molecular	ADJ
ecletica-1173	775	7	biology	biology	NOUN
ecletica-1173	775	8	.	.	PUNCT
ecletica-1173	776	1	scientists	scientist	NOUN
ecletica-1173	776	2	now	now	ADV
ecletica-1173	776	3	have	have	VERB
ecletica-1173	776	4	the	the	DET
ecletica-1173	776	5	tools	tool	NOUN
ecletica-1173	776	6	to	to	PART
ecletica-1173	776	7	unravel	unravel	VERB
ecletica-1173	776	8	biological	biological	ADJ
ecletica-1173	776	9	and	and	CCONJ
ecletica-1173	776	10	overcome	overcome	VERB
ecletica-1173	776	11	the	the	DET
ecletica-1173	776	12	limitations	limitation	NOUN
ecletica-1173	776	13	of	of	ADP
ecletica-1173	776	14	reductionism	reductionism	NOUN
ecletica-1173	776	15	.	.	PUNCT
ecletica-1173	777	1	embo	embo	PROPN
ecletica-1173	777	2	rep	rep	PROPN
ecletica-1173	777	3	.	.	PROPN
ecletica-1173	777	4	2004	2004	NUM
ecletica-1173	777	5	,	,	PUNCT
ecletica-1173	777	6	5	5	NUM
ecletica-1173	777	7	(	(	PUNCT
ecletica-1173	777	8	11	11	NUM
ecletica-1173	777	9	)	)	PUNCT
ecletica-1173	777	10	,	,	PUNCT
ecletica-1173	777	11	1016–1020	1016–1020	NUM
ecletica-1173	777	12	.	.	PUNCT
ecletica-1173	778	1	https://doi.org/10.1038/sj.embor.7400284	https://doi.org/10.1038/sj.embor.7400284	PROPN
ecletica-1173	778	2	.	.	PUNCT
ecletica-1173	779	1	van	van	PROPN
ecletica-1173	779	2	regenmortel	regenmortel	PROPN
ecletica-1173	779	3	,	,	PUNCT
ecletica-1173	779	4	m.	m.	NOUN
ecletica-1173	779	5	h.	h.	PROPN
ecletica-1173	780	1	v.	v.	PROPN
ecletica-1173	780	2	reductionism	reductionism	NOUN
ecletica-1173	780	3	and	and	CCONJ
ecletica-1173	780	4	the	the	DET
ecletica-1173	780	5	search	search	NOUN
ecletica-1173	780	6	for	for	ADP
ecletica-1173	780	7	structure	structure	NOUN
ecletica-1173	780	8	-	-	PUNCT
ecletica-1173	780	9	function	function	NOUN
ecletica-1173	780	10	relationships	relationship	NOUN
ecletica-1173	780	11	in	in	ADP
ecletica-1173	780	12	antibody	antibody	NOUN
ecletica-1173	780	13	molecules	molecule	NOUN
ecletica-1173	780	14	.	.	PUNCT
ecletica-1173	781	1	j.	j.	PROPN
ecletica-1173	781	2	mol	mol	PROPN
ecletica-1173	781	3	.	.	PROPN
ecletica-1173	781	4	recognit	recognit	PROPN
ecletica-1173	781	5	.	.	PROPN
ecletica-1173	782	1	2002	2002	NUM
ecletica-1173	782	2	,	,	PUNCT
ecletica-1173	782	3	15	15	NUM
ecletica-1173	782	4	(	(	PUNCT
ecletica-1173	782	5	5	5	NUM
ecletica-1173	782	6	)	)	PUNCT
ecletica-1173	782	7	,	,	PUNCT
ecletica-1173	782	8	240–247	240–247	NUM
ecletica-1173	782	9	.	.	PUNCT
ecletica-1173	783	1	https://doi.org/10.1002/jmr.584	https://doi.org/10.1002/jmr.584	PROPN
ecletica-1173	783	2	.	.	PUNCT
ecletica-1173	784	1	van	van	PROPN
ecletica-1173	784	2	regenmortel	regenmortel	PROPN
ecletica-1173	784	3	,	,	PUNCT
ecletica-1173	784	4	m.	m.	NOUN
ecletica-1173	784	5	h.	h.	PROPN
ecletica-1173	785	1	v.	v.	CCONJ
ecletica-1173	785	2	what	what	PRON
ecletica-1173	785	3	does	do	AUX
ecletica-1173	785	4	it	it	PRON
ecletica-1173	785	5	mean	mean	VERB
ecletica-1173	785	6	to	to	PART
ecletica-1173	785	7	develop	develop	VERB
ecletica-1173	785	8	an	an	DET
ecletica-1173	785	9	hiv	hiv	PROPN
ecletica-1173	785	10	vaccine	vaccine	NOUN
ecletica-1173	785	11	by	by	ADP
ecletica-1173	785	12	rational	rational	ADJ
ecletica-1173	785	13	design	design	NOUN
ecletica-1173	785	14	?	?	PUNCT
ecletica-1173	786	1	arch	arch	NOUN
ecletica-1173	786	2	.	.	PUNCT
ecletica-1173	787	1	virol	virol	NOUN
ecletica-1173	787	2	.	.	PUNCT
ecletica-1173	788	1	2021	2021	NUM
ecletica-1173	788	2	,	,	PUNCT
ecletica-1173	788	3	166	166	NUM
ecletica-1173	788	4	,	,	PUNCT
ecletica-1173	788	5	27	27	NUM
ecletica-1173	788	6	–	–	SYM
ecletica-1173	788	7	33	33	NUM
ecletica-1173	788	8	.	.	PUNCT
ecletica-1173	789	1	https://doi.org/10.1007/s00705-020-04884-0	https://doi.org/10.1007/s00705-020-04884-0	NUM
ecletica-1173	789	2	.	.	PUNCT
ecletica-1173	790	1	waddington	waddington	PROPN
ecletica-1173	790	2	,	,	PUNCT
ecletica-1173	790	3	c.	c.	PROPN
ecletica-1173	790	4	h.	h.	PROPN
ecletica-1173	790	5	cancer	cancer	PROPN
ecletica-1173	790	6	and	and	CCONJ
ecletica-1173	790	7	the	the	DET
ecletica-1173	790	8	theory	theory	NOUN
ecletica-1173	790	9	of	of	ADP
ecletica-1173	790	10	organisers	organiser	NOUN
ecletica-1173	790	11	.	.	PUNCT
ecletica-1173	791	1	nature	nature	NOUN
ecletica-1173	791	2	1935	1935	NUM
ecletica-1173	791	3	,	,	PUNCT
ecletica-1173	791	4	135	135	NUM
ecletica-1173	791	5	,	,	PUNCT
ecletica-1173	791	6	606–608	606–608	NUM
ecletica-1173	791	7	.	.	PUNCT
ecletica-1173	792	1	https://doi.org/10.1038/135606a0	https://doi.org/10.1038/135606a0	X
ecletica-1173	792	2	.	.	PUNCT
ecletica-1173	793	1	weinberg	weinberg	PROPN
ecletica-1173	793	2	,	,	PUNCT
ecletica-1173	793	3	r.	r.	PROPN
ecletica-1173	793	4	a.	a.	NOUN
ecletica-1173	793	5	one	one	NUM
ecletica-1173	793	6	renegade	renegade	NOUN
ecletica-1173	793	7	cell	cell	NOUN
ecletica-1173	793	8	:	:	PUNCT
ecletica-1173	793	9	the	the	DET
ecletica-1173	793	10	quest	quest	NOUN
ecletica-1173	793	11	for	for	ADP
ecletica-1173	793	12	the	the	DET
ecletica-1173	793	13	origins	origin	NOUN
ecletica-1173	793	14	of	of	ADP
ecletica-1173	793	15	cancer	cancer	NOUN
ecletica-1173	793	16	;	;	PUNCT
ecletica-1173	793	17	weidenfeld	weidenfeld	NOUN
ecletica-1173	793	18	and	and	CCONJ
ecletica-1173	793	19	nicolson	nicolson	PROPN
ecletica-1173	793	20	:	:	PUNCT
ecletica-1173	793	21	science	science	NOUN
ecletica-1173	793	22	masters	master	NOUN
ecletica-1173	793	23	,	,	PUNCT
ecletica-1173	793	24	1998	1998	NUM
ecletica-1173	793	25	.	.	PUNCT
ecletica-1173	794	1	weinstock	weinstock	PROPN
ecletica-1173	794	2	,	,	PUNCT
ecletica-1173	794	3	g.	g.	PROPN
ecletica-1173	794	4	m.	m.	PROPN
ecletica-1173	794	5	genomic	genomic	PROPN
ecletica-1173	794	6	approaches	approach	NOUN
ecletica-1173	794	7	to	to	ADP
ecletica-1173	794	8	studying	study	VERB
ecletica-1173	794	9	the	the	DET
ecletica-1173	794	10	human	human	ADJ
ecletica-1173	794	11	microbiota	microbiota	NOUN
ecletica-1173	794	12	.	.	PUNCT
ecletica-1173	795	1	nature	nature	NOUN
ecletica-1173	795	2	2012	2012	NUM
ecletica-1173	795	3	,	,	PUNCT
ecletica-1173	795	4	489	489	NUM
ecletica-1173	795	5	(	(	PUNCT
ecletica-1173	795	6	7415	7415	NUM
ecletica-1173	795	7	)	)	PUNCT
ecletica-1173	795	8	,	,	PUNCT
ecletica-1173	795	9	250–256	250–256	NUM
ecletica-1173	795	10	.	.	PUNCT
ecletica-1173	796	1	https://doi.org/10.1038/nature11553	https://doi.org/10.1038/nature11553	PROPN
ecletica-1173	796	2	.	.	PUNCT
ecletica-1173	796	3	woolley	woolley	PROPN
ecletica-1173	796	4	,	,	PUNCT
ecletica-1173	796	5	r.	r.	PROPN
ecletica-1173	796	6	g.	g.	PROPN
ecletica-1173	796	7	must	must	AUX
ecletica-1173	796	8	a	a	DET
ecletica-1173	796	9	molecule	molecule	NOUN
ecletica-1173	796	10	have	have	VERB
ecletica-1173	796	11	a	a	DET
ecletica-1173	796	12	shape	shape	NOUN
ecletica-1173	796	13	?	?	PUNCT
ecletica-1173	797	1	j.	j.	PROPN
ecletica-1173	797	2	am	am	PROPN
ecletica-1173	797	3	.	.	PUNCT
ecletica-1173	798	1	chem	chem	NOUN
ecletica-1173	798	2	.	.	PUNCT
ecletica-1173	799	1	soc	soc	PROPN
ecletica-1173	799	2	.	.	PUNCT
ecletica-1173	800	1	1978	1978	NUM
ecletica-1173	800	2	,	,	PUNCT
ecletica-1173	800	3	100	100	NUM
ecletica-1173	800	4	(	(	PUNCT
ecletica-1173	800	5	4	4	NUM
ecletica-1173	800	6	)	)	PUNCT
ecletica-1173	800	7	,	,	PUNCT
ecletica-1173	800	8	1073–1078	1073–1078	NUM
ecletica-1173	800	9	.	.	PUNCT
ecletica-1173	801	1	https://doi.org/10.1021/ja00472a009	https://doi.org/10.1021/ja00472a009	PROPN
ecletica-1173	801	2	.	.	PUNCT
ecletica-1173	802	1	zalta	zalta	PROPN
ecletica-1173	802	2	,	,	PUNCT
ecletica-1173	802	3	e.	e.	PROPN
ecletica-1173	802	4	n.	n.	PROPN
ecletica-1173	802	5	;	;	PUNCT
ecletica-1173	802	6	nodelman	nodelman	NOUN
ecletica-1173	802	7	,	,	PUNCT
ecletica-1173	802	8	u.	u.	PROPN
ecletica-1173	802	9	;	;	PUNCT
ecletica-1173	802	10	allen	allen	PROPN
ecletica-1173	802	11	,	,	PUNCT
ecletica-1173	802	12	c.	c.	PROPN
ecletica-1173	802	13	;	;	PUNCT
ecletica-1173	802	14	anderson	anderson	PROPN
ecletica-1173	802	15	.	.	PUNCT
ecletica-1173	803	1	r.	r.	PROPN
ecletica-1173	803	2	l.	l.	PROPN
ecletica-1173	803	3	reductionism	reductionism	PROPN
ecletica-1173	803	4	in	in	ADP
ecletica-1173	803	5	biology	biology	NOUN
ecletica-1173	803	6	.	.	PUNCT
ecletica-1173	804	1	stanford	stanford	PROPN
ecletica-1173	804	2	encyclopedia	encyclopedia	NOUN
ecletica-1173	804	3	of	of	ADP
ecletica-1173	804	4	philosophy	philosophy	NOUN
ecletica-1173	804	5	,	,	PUNCT
ecletica-1173	804	6	2017	2017	NUM
ecletica-1173	804	7	.	.	PUNCT
ecletica-1173	805	1	https://plato.stanford.edu/entries/reduction-biology/	https://plato.stanford.edu/entries/reduction-biology/	NOUN
ecletica-1173	805	2	(	(	PUNCT
ecletica-1173	805	3	accessed	access	VERB
ecletica-1173	805	4	2021	2021	NUM
ecletica-1173	805	5	-	-	SYM
ecletica-1173	805	6	04	04	NUM
ecletica-1173	805	7	-	-	PUNCT
ecletica-1173	805	8	21	21	NUM
ecletica-1173	805	9	)	)	PUNCT
ecletica-1173	805	10	.	.	PUNCT
ecletica-1173	806	1	zhong	zhong	PROPN
ecletica-1173	806	2	,	,	PUNCT
ecletica-1173	806	3	z.	z.	PROPN
ecletica-1173	806	4	;	;	PUNCT
ecletica-1173	806	5	virshup	virshup	PROPN
ecletica-1173	806	6	,	,	PUNCT
ecletica-1173	806	7	d.	d.	PROPN
ecletica-1173	806	8	m.	m.	PROPN
ecletica-1173	806	9	wnt	wnt	PROPN
ecletica-1173	806	10	signaling	signal	VERB
ecletica-1173	806	11	and	and	CCONJ
ecletica-1173	806	12	drug	drug	NOUN
ecletica-1173	806	13	resistance	resistance	NOUN
ecletica-1173	806	14	in	in	ADP
ecletica-1173	806	15	cancer	cancer	NOUN
ecletica-1173	806	16	.	.	PUNCT
ecletica-1173	807	1	mol	mol	PROPN
ecletica-1173	807	2	.	.	PUNCT
ecletica-1173	807	3	pharmacol	pharmacol	PROPN
ecletica-1173	807	4	.	.	PUNCT
ecletica-1173	808	1	2020	2020	NUM
ecletica-1173	808	2	,	,	PUNCT
ecletica-1173	808	3	97	97	NUM
ecletica-1173	808	4	(	(	PUNCT
ecletica-1173	808	5	2	2	NUM
ecletica-1173	808	6	)	)	PUNCT
ecletica-1173	808	7	,	,	PUNCT
ecletica-1173	808	8	72–89	72–89	NUM
ecletica-1173	808	9	.	.	PUNCT
ecletica-1173	808	10	https://doi.org/10.1124/mol.119.117978	https://doi.org/10.1124/mol.119.117978	PROPN
ecletica-1173	808	11	.	.	PUNCT
ecletica-1173	809	1	http://revista.iq.unesp.br/ojs/index.php/ecletica/index	http://revista.iq.unesp.br/ojs/index.php/ecletica/index	NOUN
ecletica-1173	809	2	https://doi.org/10.26850/1678-4618eqj.v46.3.2021.p17-32	https://doi.org/10.26850/1678-4618eqj.v46.3.2021.p17-32	PROPN
ecletica-1173	809	3	https://doi.org/10.1016/j.sbi.2020.08.006	https://doi.org/10.1016/j.sbi.2020.08.006	PROPN
ecletica-1173	809	4	https://doi.org/10.1016/j.sbi.2020.08.006	https://doi.org/10.1016/j.sbi.2020.08.006	PRON
ecletica-1173	809	5	https://doi.org/10.1016/j.sbi.2020.08.006	https://doi.org/10.1016/j.sbi.2020.08.006	ADJ
ecletica-1173	809	6	https://doi.org/10.1007/s12263-008-0090-5	https://doi.org/10.1007/s12263-008-0090-5	NOUN
ecletica-1173	809	7	https://doi.org/10.1007/s12263-008-0090-5	https://doi.org/10.1007/s12263-008-0090-5	NOUN
ecletica-1173	809	8	https://doi.org/10.1007/s12263-008-0090-5	https://doi.org/10.1007/s12263-008-0090-5	NOUN
ecletica-1173	809	9	https://doi.org/10.1007/s12263-008-0090-5	https://doi.org/10.1007/s12263-008-0090-5	NUM
ecletica-1173	809	10	https://doi.org/10.1002/(sici)1099-1352(200001/02)13:1%3c1::aid-jmr490%3e3.0.co;2-w	https://doi.org/10.1002/(sici)1099-1352(200001/02)13:1%3c1::aid-jmr490%3e3.0.co;2-w	PROPN
ecletica-1173	809	11	https://doi.org/10.1002/(sici)1099-1352(200001/02)13:1%3c1::aid-jmr490%3e3.0.co;2-w	https://doi.org/10.1002/(sici)1099-1352(200001/02)13:1%3c1::aid-jmr490%3e3.0.co;2-w	PROPN
ecletica-1173	809	12	https://doi.org/10.1002/(sici)1099-1352(200001/02)13:1%3c1::aid-jmr490%3e3.0.co;2-w	https://doi.org/10.1002/(sici)1099-1352(200001/02)13:1%3c1::aid-jmr490%3e3.0.co;2-w	PROPN
ecletica-1173	809	13	https://doi.org/10.1002/(sici)1099-1352(200001/02)13:1%3c1::aid-jmr490%3e3.0.co;2-w	https://doi.org/10.1002/(sici)1099-1352(200001/02)13:1%3c1::aid-jmr490%3e3.0.co;2-w	PROPN
ecletica-1173	809	14	https://doi.org/10.1002/(sici)1099-1352(200001/02)13:1%3c1::aid-jmr490%3e3.0.co;2-w	https://doi.org/10.1002/(sici)1099-1352(200001/02)13:1%3c1::aid-jmr490%3e3.0.co;2-w	PROPN
ecletica-1173	809	15	https://doi.org/10.1016/s0264-410x(00)00456-4	https://doi.org/10.1016/s0264-410x(00)00456-4	PROPN
ecletica-1173	809	16	https://doi.org/10.1016/s0264-410x(00)00456-4	https://doi.org/10.1016/s0264-410x(00)00456-4	PROPN
ecletica-1173	809	17	https://doi.org/10.1016/s0264-410x(00)00456-4	https://doi.org/10.1016/s0264-410x(00)00456-4	PROPN
ecletica-1173	809	18	https://doi.org/10.1016/s0264-410x(00)00456-4	https://doi.org/10.1016/s0264-410x(00)00456-4	PROPN
ecletica-1173	809	19	https://doi.org/10.1038/sj.embor.7400284	https://doi.org/10.1038/sj.embor.7400284	NOUN
ecletica-1173	809	20	https://doi.org/10.1038/sj.embor.7400284	https://doi.org/10.1038/sj.embor.7400284	PROPN
ecletica-1173	809	21	https://doi.org/10.1038/sj.embor.7400284	https://doi.org/10.1038/sj.embor.7400284	PROPN
ecletica-1173	809	22	https://doi.org/10.1038/sj.embor.7400284	https://doi.org/10.1038/sj.embor.7400284	PROPN
ecletica-1173	809	23	https://doi.org/10.1038/sj.embor.7400284	https://doi.org/10.1038/sj.embor.7400284	NOUN
ecletica-1173	809	24	https://doi.org/10.1002/jmr.584	https://doi.org/10.1002/jmr.584	PROPN
ecletica-1173	809	25	https://doi.org/10.1002/jmr.584	https://doi.org/10.1002/jmr.584	PROPN
ecletica-1173	809	26	https://doi.org/10.1002/jmr.584	https://doi.org/10.1002/jmr.584	PROPN
ecletica-1173	809	27	https://doi.org/10.1002/jmr.584	https://doi.org/10.1002/jmr.584	PROPN
ecletica-1173	809	28	https://doi.org/10.1007/s00705-020-04884-0	https://doi.org/10.1007/s00705-020-04884-0	NUM
ecletica-1173	809	29	https://doi.org/10.1007/s00705-020-04884-0	https://doi.org/10.1007/s00705-020-04884-0	NUM
ecletica-1173	809	30	https://doi.org/10.1007/s00705-020-04884-0	https://doi.org/10.1007/s00705-020-04884-0	NUM
ecletica-1173	809	31	https://doi.org/10.1038/135606a0	https://doi.org/10.1038/135606a0	NUM
ecletica-1173	809	32	https://doi.org/10.1038/135606a0	https://doi.org/10.1038/135606a0	NUM
ecletica-1173	809	33	https://doi.org/10.1038/135606a0	https://doi.org/10.1038/135606a0	NUM
ecletica-1173	809	34	https://doi.org/10.1038/nature11553	https://doi.org/10.1038/nature11553	PROPN
ecletica-1173	809	35	https://doi.org/10.1038/nature11553	https://doi.org/10.1038/nature11553	PROPN
ecletica-1173	809	36	https://doi.org/10.1038/nature11553	https://doi.org/10.1038/nature11553	PROPN
ecletica-1173	809	37	https://doi.org/10.1021/ja00472a009	https://doi.org/10.1021/ja00472a009	PROPN
ecletica-1173	809	38	https://doi.org/10.1021/ja00472a009	https://doi.org/10.1021/ja00472a009	PROPN
ecletica-1173	809	39	https://doi.org/10.1021/ja00472a009	https://doi.org/10.1021/ja00472a009	PROPN
ecletica-1173	810	1	https://plato.stanford.edu/entries/reduction-biology/	https://plato.stanford.edu/entries/reduction-biology/	PROPN
ecletica-1173	811	1	https://plato.stanford.edu/entries/reduction-biology/	https://plato.stanford.edu/entries/reduction-biology/	NOUN
ecletica-1173	812	1	https://plato.stanford.edu/entries/reduction-biology/	https://plato.stanford.edu/entries/reduction-biology/	NOUN
ecletica-1173	812	2	https://plato.stanford.edu/entries/reduction-biology/	https://plato.stanford.edu/entries/reduction-biology/	PROPN
ecletica-1173	812	3	https://plato.stanford.edu/entries/reduction-biology/	https://plato.stanford.edu/entries/reduction-biology/	PROPN
ecletica-1173	812	4	https://doi.org/10.1124/mol.119.117978	https://doi.org/10.1124/mol.119.117978	ADP
ecletica-1173	812	5	https://doi.org/10.1124/mol.119.117978	https://doi.org/10.1124/mol.119.117978	NOUN
ecletica-1173	812	6	https://doi.org/10.1124/mol.119.117978	https://doi.org/10.1124/mol.119.117978	NOUN