id	sid	tid	token	lemma	pos
ecletica-285	1	1	www.scielo.br/eq	www.scielo.br/eq	NOUN
ecletica-285	1	2	volume	volume	NOUN
ecletica-285	1	3	34	34	NUM
ecletica-285	1	4	,	,	PUNCT
ecletica-285	1	5	número	número	NOUN
ecletica-285	1	6	4	4	NUM
ecletica-285	1	7	,	,	PUNCT
ecletica-285	1	8	2009	2009	NUM
ecletica-285	1	9	87	87	NUM
ecletica-285	1	10	inhibitors	inhibitor	NOUN
ecletica-285	1	11	of	of	ADP
ecletica-285	1	12	human	human	ADJ
ecletica-285	1	13	collagenase	collagenase	NOUN
ecletica-285	1	14	,	,	PUNCT
ecletica-285	1	15	mmp1	mmp1	PROPN
ecletica-285	1	16	sergio	sergio	PROPN
ecletica-285	1	17	roberto	roberto	PROPN
ecletica-285	1	18	de	de	PROPN
ecletica-285	1	19	andrade	andrade	PROPN
ecletica-285	1	20	leite	leite	PROPN
ecletica-285	1	21	instituto	instituto	PROPN
ecletica-285	1	22	de	de	PROPN
ecletica-285	1	23	química	química	PROPN
ecletica-285	1	24	,	,	PUNCT
ecletica-285	1	25	unesp	unesp	NOUN
ecletica-285	1	26	,	,	PUNCT
ecletica-285	1	27	cp	cp	PROPN
ecletica-285	1	28	355	355	NUM
ecletica-285	1	29	,	,	PUNCT
ecletica-285	1	30	14801	14801	NUM
ecletica-285	1	31	-	-	SYM
ecletica-285	1	32	970	970	NUM
ecletica-285	1	33	,	,	PUNCT
ecletica-285	1	34	araraquara	araraquara	NOUN
ecletica-285	1	35	,	,	PUNCT
ecletica-285	1	36	sp	sp	NOUN
ecletica-285	1	37	,	,	PUNCT
ecletica-285	1	38	brasil	brasil	PROPN
ecletica-285	1	39	e	e	NOUN
ecletica-285	1	40	-	-	NOUN
ecletica-285	1	41	mail	mail	NOUN
ecletica-285	1	42	address	address	NOUN
ecletica-285	1	43	:	:	PUNCT
ecletica-285	1	44	leite@iq.unesp.br	leite@iq.unesp.br	NOUN
ecletica-285	1	45	abstract	abstract	ADJ
ecletica-285	1	46	:	:	PUNCT
ecletica-285	1	47	different	different	ADJ
ecletica-285	1	48	common	common	ADJ
ecletica-285	1	49	drugs	drug	NOUN
ecletica-285	1	50	(	(	PUNCT
ecletica-285	1	51	meloxicam	meloxicam	NOUN
ecletica-285	1	52	,	,	PUNCT
ecletica-285	1	53	tenoxicam	tenoxicam	NOUN
ecletica-285	1	54	and	and	CCONJ
ecletica-285	1	55	piroxicam	piroxicam	VERB
ecletica-285	1	56	,	,	PUNCT
ecletica-285	1	57	and	and	CCONJ
ecletica-285	1	58	sodium	sodium	NOUN
ecletica-285	1	59	alendronate	alendronate	NOUN
ecletica-285	1	60	)	)	PUNCT
ecletica-285	1	61	were	be	AUX
ecletica-285	1	62	tested	test	VERB
ecletica-285	1	63	both	both	CCONJ
ecletica-285	1	64	experimental	experimental	ADJ
ecletica-285	1	65	and	and	CCONJ
ecletica-285	1	66	theoretically	theoretically	ADV
ecletica-285	1	67	as	as	ADP
ecletica-285	1	68	inhibitors	inhibitor	NOUN
ecletica-285	1	69	of	of	ADP
ecletica-285	1	70	interstitial	interstitial	ADJ
ecletica-285	1	71	human	human	ADJ
ecletica-285	1	72	collagenase	collagenase	NOUN
ecletica-285	1	73	,	,	PUNCT
ecletica-285	1	74	also	also	ADV
ecletica-285	1	75	known	know	VERB
ecletica-285	1	76	as	as	ADP
ecletica-285	1	77	matrix	matrix	NOUN
ecletica-285	1	78	metalloproteinase	metalloproteinase	NOUN
ecletica-285	1	79	1	1	NUM
ecletica-285	1	80	(	(	PUNCT
ecletica-285	1	81	mmp-1	mmp-1	NOUN
ecletica-285	1	82	)	)	PUNCT
ecletica-285	1	83	.	.	PUNCT
ecletica-285	2	1	the	the	DET
ecletica-285	2	2	in	in	ADP
ecletica-285	2	3	vitro	vitro	X
ecletica-285	2	4	collagenase	collagenase	NOUN
ecletica-285	2	5	activity	activity	NOUN
ecletica-285	2	6	,	,	PUNCT
ecletica-285	2	7	alone	alone	ADJ
ecletica-285	2	8	and	and	CCONJ
ecletica-285	2	9	in	in	ADP
ecletica-285	2	10	the	the	DET
ecletica-285	2	11	presence	presence	NOUN
ecletica-285	2	12	of	of	ADP
ecletica-285	2	13	inhibitors	inhibitor	NOUN
ecletica-285	2	14	,	,	PUNCT
ecletica-285	2	15	was	be	AUX
ecletica-285	2	16	quantified	quantify	VERB
ecletica-285	2	17	by	by	ADP
ecletica-285	2	18	the	the	DET
ecletica-285	2	19	reaction	reaction	NOUN
ecletica-285	2	20	with	with	ADP
ecletica-285	2	21	a	a	DET
ecletica-285	2	22	fluorescent	fluorescent	ADJ
ecletica-285	2	23	synthetic	synthetic	ADJ
ecletica-285	2	24	substrate	substrate	NOUN
ecletica-285	2	25	and	and	CCONJ
ecletica-285	2	26	measuring	measure	VERB
ecletica-285	2	27	the	the	DET
ecletica-285	2	28	change	change	NOUN
ecletica-285	2	29	of	of	ADP
ecletica-285	2	30	emission	emission	NOUN
ecletica-285	2	31	.	.	PUNCT
ecletica-285	3	1	collagenase	collagenase	NOUN
ecletica-285	3	2	-	-	PUNCT
ecletica-285	3	3	inhibitor	inhibitor	NOUN
ecletica-285	3	4	interaction	interaction	NOUN
ecletica-285	3	5	was	be	AUX
ecletica-285	3	6	studied	study	VERB
ecletica-285	3	7	theoretically	theoretically	ADV
ecletica-285	3	8	by	by	ADP
ecletica-285	3	9	computational	computational	ADJ
ecletica-285	3	10	calculations	calculation	NOUN
ecletica-285	3	11	.	.	PUNCT
ecletica-285	4	1	three	three	NUM
ecletica-285	4	2	among	among	ADP
ecletica-285	4	3	the	the	DET
ecletica-285	4	4	four	four	NUM
ecletica-285	4	5	tested	test	VERB
ecletica-285	4	6	substances	substance	NOUN
ecletica-285	4	7	showed	show	VERB
ecletica-285	4	8	moderate	moderate	ADJ
ecletica-285	4	9	inhibiting	inhibit	VERB
ecletica-285	4	10	activity	activity	NOUN
ecletica-285	4	11	against	against	ADP
ecletica-285	4	12	the	the	DET
ecletica-285	4	13	human	human	ADJ
ecletica-285	4	14	collagenase	collagenase	NOUN
ecletica-285	4	15	.	.	PUNCT
ecletica-285	5	1	keywords	keyword	NOUN
ecletica-285	5	2	:	:	PUNCT
ecletica-285	5	3	collagenase	collagenase	NOUN
ecletica-285	5	4	,	,	PUNCT
ecletica-285	5	5	mmp-1	mmp-1	ADP
ecletica-285	5	6	,	,	PUNCT
ecletica-285	5	7	human	human	ADJ
ecletica-285	5	8	metalloproteinases	metalloproteinase	NOUN
ecletica-285	5	9	,	,	PUNCT
ecletica-285	5	10	inhibitors	inhibitor	NOUN
ecletica-285	5	11	,	,	PUNCT
ecletica-285	5	12	docking	docking	NOUN
ecletica-285	5	13	.	.	PUNCT
ecletica-285	6	1	introduction	introduction	NOUN
ecletica-285	6	2	the	the	DET
ecletica-285	6	3	metalloproteinases	metalloproteinase	NOUN
ecletica-285	6	4	of	of	ADP
ecletica-285	6	5	the	the	DET
ecletica-285	6	6	conjunctive	conjunctive	ADJ
ecletica-285	6	7	matrix	matrix	NOUN
ecletica-285	6	8	,	,	PUNCT
ecletica-285	6	9	also	also	ADV
ecletica-285	6	10	known	know	VERB
ecletica-285	6	11	as	as	ADP
ecletica-285	6	12	matrixins	matrixin	NOUN
ecletica-285	6	13	or	or	CCONJ
ecletica-285	6	14	mmp	mmp	PROPN
ecletica-285	6	15	(	(	PUNCT
ecletica-285	6	16	the	the	DET
ecletica-285	6	17	acronym	acronym	NOUN
ecletica-285	6	18	of	of	ADP
ecletica-285	6	19	matrix	matrix	NOUN
ecletica-285	6	20	metallo	metallo	NOUN
ecletica-285	6	21	proteinase	proteinase	NOUN
ecletica-285	6	22	)	)	PUNCT
ecletica-285	6	23	,	,	PUNCT
ecletica-285	6	24	constitute	constitute	VERB
ecletica-285	6	25	a	a	DET
ecletica-285	6	26	subgroup	subgroup	NOUN
ecletica-285	6	27	of	of	ADP
ecletica-285	6	28	the	the	DET
ecletica-285	6	29	zinc	zinc	NOUN
ecletica-285	6	30	-	-	PUNCT
ecletica-285	6	31	endoproteases	endoprotease	NOUN
ecletica-285	6	32	produced	produce	VERB
ecletica-285	6	33	by	by	ADP
ecletica-285	6	34	the	the	DET
ecletica-285	6	35	conjunctive	conjunctive	ADJ
ecletica-285	6	36	tissue	tissue	NOUN
ecletica-285	6	37	.	.	PUNCT
ecletica-285	7	1	these	these	DET
ecletica-285	7	2	enzymes	enzyme	NOUN
ecletica-285	7	3	participate	participate	VERB
ecletica-285	7	4	in	in	ADP
ecletica-285	7	5	the	the	DET
ecletica-285	7	6	initial	initial	ADJ
ecletica-285	7	7	events	event	NOUN
ecletica-285	7	8	that	that	PRON
ecletica-285	7	9	result	result	VERB
ecletica-285	7	10	in	in	ADP
ecletica-285	7	11	tissue	tissue	NOUN
ecletica-285	7	12	degradation	degradation	NOUN
ecletica-285	7	13	,	,	PUNCT
ecletica-285	7	14	both	both	CCONJ
ecletica-285	7	15	in	in	ADP
ecletica-285	7	16	physiologic	physiologic	ADJ
ecletica-285	7	17	and	and	CCONJ
ecletica-285	7	18	pathologic	pathologic	ADJ
ecletica-285	7	19	conditions	condition	NOUN
ecletica-285	7	20	.	.	PUNCT
ecletica-285	8	1	they	they	PRON
ecletica-285	8	2	are	be	AUX
ecletica-285	8	3	divided	divide	VERB
ecletica-285	8	4	in	in	ADP
ecletica-285	8	5	five	five	NUM
ecletica-285	8	6	groups	group	NOUN
ecletica-285	8	7	:	:	PUNCT
ecletica-285	8	8	1	1	X
ecletica-285	8	9	.	.	NUM
ecletica-285	8	10	collagenases	collagenase	NOUN
ecletica-285	8	11	that	that	PRON
ecletica-285	8	12	hydrolyze	hydrolyze	VERB
ecletica-285	8	13	the	the	DET
ecletica-285	8	14	collagen	collagen	NOUN
ecletica-285	8	15	,	,	PUNCT
ecletica-285	8	16	protein	protein	NOUN
ecletica-285	8	17	resistant	resistant	ADJ
ecletica-285	8	18	to	to	ADP
ecletica-285	8	19	most	most	ADJ
ecletica-285	8	20	of	of	ADP
ecletica-285	8	21	the	the	DET
ecletica-285	8	22	proteases	protease	NOUN
ecletica-285	8	23	;	;	PUNCT
ecletica-285	8	24	2	2	X
ecletica-285	8	25	.	.	NOUN
ecletica-285	8	26	gelatinases	gelatinase	NOUN
ecletica-285	8	27	,	,	PUNCT
ecletica-285	8	28	thus	thus	ADV
ecletica-285	8	29	named	name	VERB
ecletica-285	8	30	because	because	SCONJ
ecletica-285	8	31	they	they	PRON
ecletica-285	8	32	hydrolyze	hydrolyze	VERB
ecletica-285	8	33	denatured	denature	VERB
ecletica-285	8	34	collagen	collagen	NOUN
ecletica-285	8	35	,	,	PUNCT
ecletica-285	8	36	also	also	ADV
ecletica-285	8	37	known	know	VERB
ecletica-285	8	38	as	as	ADP
ecletica-285	8	39	type	type	NOUN
ecletica-285	8	40	iv	iv	NUM
ecletica-285	8	41	collagenases	collagenase	NOUN
ecletica-285	8	42	,	,	PUNCT
ecletica-285	8	43	for	for	SCONJ
ecletica-285	8	44	they	they	PRON
ecletica-285	8	45	also	also	ADV
ecletica-285	8	46	degrade	degrade	VERB
ecletica-285	8	47	native	native	ADJ
ecletica-285	8	48	collagen	collagen	NOUN
ecletica-285	8	49	type	type	NOUN
ecletica-285	8	50	iv	iv	ADP
ecletica-285	8	51	;	;	PUNCT
ecletica-285	9	1	3	3	X
ecletica-285	9	2	.	.	X
ecletica-285	9	3	stromelysins	stromelysin	NOUN
ecletica-285	9	4	,	,	PUNCT
ecletica-285	9	5	originally	originally	ADV
ecletica-285	9	6	described	describe	VERB
ecletica-285	9	7	as	as	ADP
ecletica-285	9	8	proteoglycanases	proteoglycanase	NOUN
ecletica-285	9	9	,	,	PUNCT
ecletica-285	9	10	but	but	CCONJ
ecletica-285	9	11	that	that	PRON
ecletica-285	9	12	actually	actually	ADV
ecletica-285	9	13	possess	possess	VERB
ecletica-285	9	14	a	a	DET
ecletica-285	9	15	reasonably	reasonably	ADV
ecletica-285	9	16	wide	wide	ADJ
ecletica-285	9	17	proteolytic	proteolytic	ADJ
ecletica-285	9	18	activity	activity	NOUN
ecletica-285	9	19	;	;	PUNCT
ecletica-285	9	20	4	4	X
ecletica-285	9	21	.	.	X
ecletica-285	9	22	pump	pump	NOUN
ecletica-285	9	23	;	;	PUNCT
ecletica-285	9	24	5	5	X
ecletica-285	9	25	.	.	X
ecletica-285	9	26	stromelysin	stromelysin	PROPN
ecletica-285	9	27	3	3	NUM
ecletica-285	9	28	.	.	PUNCT
ecletica-285	10	1	murphy	murphy	PROPN
ecletica-285	10	2	et	et	PROPN
ecletica-285	10	3	al	al	PROPN
ecletica-285	11	1	[	[	X
ecletica-285	11	2	1	1	X
ecletica-285	11	3	]	]	PUNCT
ecletica-285	11	4	proposed	propose	VERB
ecletica-285	11	5	a	a	DET
ecletica-285	11	6	more	more	ADV
ecletica-285	11	7	complete	complete	ADJ
ecletica-285	11	8	classification	classification	NOUN
ecletica-285	11	9	,	,	PUNCT
ecletica-285	11	10	whose	whose	DET
ecletica-285	11	11	updated	update	VERB
ecletica-285	11	12	version	version	NOUN
ecletica-285	11	13	is	be	AUX
ecletica-285	11	14	given	give	VERB
ecletica-285	11	15	below	below	ADP
ecletica-285	11	16	:	:	PUNCT
ecletica-285	11	17	1	1	X
ecletica-285	11	18	.	.	X
ecletica-285	11	19	collagenases	collagenase	NOUN
ecletica-285	11	20	:	:	PUNCT
ecletica-285	11	21	interstitial	interstitial	ADJ
ecletica-285	11	22	collagenase	collagenase	NOUN
ecletica-285	11	23	(	(	PUNCT
ecletica-285	11	24	mmp-1	mmp-1	NOUN
ecletica-285	11	25	)	)	PUNCT
ecletica-285	11	26	,	,	PUNCT
ecletica-285	11	27	neutrophil	neutrophil	ADJ
ecletica-285	11	28	collagenase	collagenase	NOUN
ecletica-285	11	29	(	(	PUNCT
ecletica-285	11	30	mmp8	mmp8	PROPN
ecletica-285	11	31	)	)	PUNCT
ecletica-285	11	32	,	,	PUNCT
ecletica-285	11	33	collagenase	collagenase	NOUN
ecletica-285	11	34	3	3	NUM
ecletica-285	11	35	(	(	PUNCT
ecletica-285	11	36	mmp-13	mmp-13	NOUN
ecletica-285	11	37	)	)	PUNCT
ecletica-285	11	38	,	,	PUNCT
ecletica-285	11	39	collagenase	collagenase	NOUN
ecletica-285	11	40	4	4	NUM
ecletica-285	11	41	(	(	PUNCT
ecletica-285	11	42	mmp-18	mmp-18	NOUN
ecletica-285	11	43	)	)	PUNCT
ecletica-285	11	44	.	.	PUNCT
ecletica-285	12	1	2	2	X
ecletica-285	12	2	.	.	X
ecletica-285	12	3	stromelysins	stromelysin	NOUN
ecletica-285	12	4	:	:	PUNCT
ecletica-285	12	5	stromelysin	stromelysin	NOUN
ecletica-285	12	6	1	1	NUM
ecletica-285	12	7	(	(	PUNCT
ecletica-285	12	8	mmp-3	mmp-3	NUM
ecletica-285	12	9	)	)	PUNCT
ecletica-285	12	10	,	,	PUNCT
ecletica-285	12	11	stromelysin	stromelysin	NOUN
ecletica-285	12	12	2	2	NUM
ecletica-285	12	13	(	(	PUNCT
ecletica-285	12	14	mmp-10	mmp-10	NOUN
ecletica-285	12	15	)	)	PUNCT
ecletica-285	12	16	,	,	PUNCT
ecletica-285	12	17	stromelysin	stromelysin	NOUN
ecletica-285	12	18	3	3	NUM
ecletica-285	12	19	(	(	PUNCT
ecletica-285	12	20	mmp11	mmp11	NOUN
ecletica-285	12	21	)	)	PUNCT
ecletica-285	12	22	,	,	PUNCT
ecletica-285	12	23	no	no	DET
ecletica-285	12	24	trivial	trivial	ADJ
ecletica-285	12	25	name	name	NOUN
ecletica-285	12	26	(	(	PUNCT
ecletica-285	12	27	mmp-19	mmp-19	NOUN
ecletica-285	12	28	)	)	PUNCT
ecletica-285	12	29	,	,	PUNCT
ecletica-285	12	30	enamelysin	enamelysin	NOUN
ecletica-285	12	31	(	(	PUNCT
ecletica-285	12	32	mmp-20	mmp-20	NOUN
ecletica-285	12	33	)	)	PUNCT
ecletica-285	12	34	.	.	PUNCT
ecletica-285	13	1	3	3	X
ecletica-285	13	2	.	.	X
ecletica-285	13	3	gelatinases	gelatinase	NOUN
ecletica-285	13	4	:	:	PUNCT
ecletica-285	13	5	gelatinase	gelatinase	NOUN
ecletica-285	13	6	a	a	DET
ecletica-285	13	7	(	(	PUNCT
ecletica-285	13	8	72	72	NUM
ecletica-285	13	9	kd	kd	NOUN
ecletica-285	13	10	,	,	PUNCT
ecletica-285	13	11	mmp-2	mmp-2	NUM
ecletica-285	13	12	)	)	PUNCT
ecletica-285	13	13	,	,	PUNCT
ecletica-285	13	14	gelatinase	gelatinase	PROPN
ecletica-285	13	15	b	b	PROPN
ecletica-285	13	16	(	(	PUNCT
ecletica-285	13	17	92	92	NUM
ecletica-285	13	18	kd	kd	NOUN
ecletica-285	13	19	,	,	PUNCT
ecletica-285	13	20	mmp-9	mmp-9	NUM
ecletica-285	13	21	)	)	PUNCT
ecletica-285	13	22	.	.	PUNCT
ecletica-285	14	1	4	4	X
ecletica-285	14	2	.	.	X
ecletica-285	14	3	membrane	membrane	NOUN
ecletica-285	14	4	collagenase	collagenase	NOUN
ecletica-285	14	5	:	:	PUNCT
ecletica-285	14	6	mt1mmp	mt1mmp	PROPN
ecletica-285	14	7	(	(	PUNCT
ecletica-285	14	8	mmp14	mmp14	PROPN
ecletica-285	14	9	)	)	PUNCT
ecletica-285	14	10	,	,	PUNCT
ecletica-285	14	11	mt2mmp	mt2mmp	PROPN
ecletica-285	14	12	(	(	PUNCT
ecletica-285	14	13	mmp-15	mmp-15	PROPN
ecletica-285	14	14	)	)	PUNCT
ecletica-285	14	15	,	,	PUNCT
ecletica-285	14	16	mt3mmp	mt3mmp	PROPN
ecletica-285	14	17	(	(	PUNCT
ecletica-285	14	18	mmp-16	mmp-16	NOUN
ecletica-285	14	19	)	)	PUNCT
ecletica-285	14	20	,	,	PUNCT
ecletica-285	14	21	mt4mmp	mt4mmp	PROPN
ecletica-285	14	22	(	(	PUNCT
ecletica-285	14	23	mmp-17	mmp-17	NOUN
ecletica-285	14	24	)	)	PUNCT
ecletica-285	14	25	.	.	PUNCT
ecletica-285	15	1	5	5	X
ecletica-285	15	2	.	.	X
ecletica-285	16	1	others	other	NOUN
ecletica-285	16	2	:	:	PUNCT
ecletica-285	16	3	matrilysin	matrilysin	VERB
ecletica-285	16	4	(	(	PUNCT
ecletica-285	16	5	mmp-7	mmp-7	NUM
ecletica-285	16	6	)	)	PUNCT
ecletica-285	16	7	,	,	PUNCT
ecletica-285	16	8	macrophage	macrophage	ADJ
ecletica-285	16	9	elastase	elastase	NOUN
ecletica-285	16	10	(	(	PUNCT
ecletica-285	16	11	mmp-12	mmp-12	NOUN
ecletica-285	16	12	)	)	PUNCT
ecletica-285	16	13	.	.	PUNCT
ecletica-285	17	1	the	the	DET
ecletica-285	17	2	3d	3d	PROPN
ecletica-285	17	3	structures	structure	NOUN
ecletica-285	17	4	of	of	ADP
ecletica-285	17	5	several	several	ADJ
ecletica-285	17	6	mmps	mmp	NOUN
ecletica-285	17	7	were	be	AUX
ecletica-285	17	8	already	already	ADV
ecletica-285	17	9	determined	determine	VERB
ecletica-285	17	10	by	by	ADP
ecletica-285	17	11	x	x	PROPN
ecletica-285	17	12	rays	ray	NOUN
ecletica-285	17	13	diffraction	diffraction	NOUN
ecletica-285	17	14	or	or	CCONJ
ecletica-285	17	15	by	by	ADP
ecletica-285	17	16	nmr	nmr	NOUN
ecletica-285	17	17	spectroscopy	spectroscopy	NOUN
ecletica-285	17	18	,	,	PUNCT
ecletica-285	17	19	alone	alone	ADV
ecletica-285	17	20	or	or	CCONJ
ecletica-285	17	21	binding	bind	VERB
ecletica-285	17	22	to	to	ADP
ecletica-285	17	23	inhibitors	inhibitor	NOUN
ecletica-285	17	24	[	[	X
ecletica-285	17	25	2	2	NUM
ecletica-285	17	26	]	]	PUNCT
ecletica-285	17	27	.	.	PUNCT
ecletica-285	18	1	inside	inside	ADP
ecletica-285	18	2	of	of	ADP
ecletica-285	18	3	the	the	DET
ecletica-285	18	4	molecule	molecule	NOUN
ecletica-285	18	5	domain	domain	NOUN
ecletica-285	18	6	responsible	responsible	ADJ
ecletica-285	18	7	for	for	ADP
ecletica-285	18	8	the	the	DET
ecletica-285	18	9	bond	bond	NOUN
ecletica-285	18	10	to	to	ADP
ecletica-285	18	11	zinc	zinc	NOUN
ecletica-285	18	12	ion	ion	NOUN
ecletica-285	18	13	,	,	PUNCT
ecletica-285	18	14	a	a	DET
ecletica-285	18	15	very	very	ADV
ecletica-285	18	16	similar	similar	ADJ
ecletica-285	18	17	sequence	sequence	NOUN
ecletica-285	18	18	exists	exist	VERB
ecletica-285	18	19	in	in	ADP
ecletica-285	18	20	all	all	PRON
ecletica-285	18	21	of	of	ADP
ecletica-285	18	22	structure	structure	NOUN
ecletica-285	18	23	-	-	PUNCT
ecletica-285	18	24	known	know	VERB
ecletica-285	18	25	zinc	zinc	NOUN
ecletica-285	18	26	proteinases	proteinase	NOUN
ecletica-285	18	27	:	:	PUNCT
ecletica-285	18	28	ala	ala	PROPN
ecletica-285	18	29	-	-	PUNCT
ecletica-285	18	30	ala	ala	PROPN
ecletica-285	18	31	-	-	PUNCT
ecletica-285	18	32	his	his	PRON
ecletica-285	18	33	-	-	PUNCT
ecletica-285	18	34	glu	glu	NOUN
ecletica-285	18	35	-	-	PUNCT
ecletica-285	18	36	hydrophobic	hydrophobic	NOUN
ecletica-285	18	37	aa	aa	NOUN
ecletica-285	18	38	-	-	PUNCT
ecletica-285	18	39	gly	gly	NOUN
ecletica-285	18	40	-	-	PUNCT
ecletica-285	18	41	his	his	PRON
ecletica-285	18	42	[	[	X
ecletica-285	18	43	3	3	NUM
ecletica-285	18	44	]	]	PUNCT
ecletica-285	18	45	,	,	PUNCT
ecletica-285	18	46	in	in	ADP
ecletica-285	18	47	which	which	PRON
ecletica-285	18	48	is	be	AUX
ecletica-285	18	49	believed	believe	VERB
ecletica-285	18	50	that	that	SCONJ
ecletica-285	18	51	the	the	DET
ecletica-285	18	52	two	two	NUM
ecletica-285	18	53	histidine	histidine	NOUN
ecletica-285	18	54	residues	residue	NOUN
ecletica-285	18	55	link	link	VERB
ecletica-285	18	56	to	to	ADP
ecletica-285	18	57	the	the	DET
ecletica-285	18	58	zinc	zinc	NOUN
ecletica-285	18	59	ion	ion	NOUN
ecletica-285	18	60	[	[	X
ecletica-285	18	61	4	4	NUM
ecletica-285	18	62	]	]	PUNCT
ecletica-285	18	63	.	.	PUNCT
ecletica-285	19	1	the	the	DET
ecletica-285	19	2	third	third	ADJ
ecletica-285	19	3	bond	bond	NOUN
ecletica-285	19	4	site	site	NOUN
ecletica-285	19	5	is	be	AUX
ecletica-285	19	6	not	not	PART
ecletica-285	19	7	known	know	VERB
ecletica-285	19	8	in	in	ADP
ecletica-285	19	9	all	all	PRON
ecletica-285	19	10	of	of	ADP
ecletica-285	19	11	the	the	DET
ecletica-285	19	12	cases	case	NOUN
ecletica-285	19	13	,	,	PUNCT
ecletica-285	19	14	unlike	unlike	ADP
ecletica-285	19	15	in	in	ADP
ecletica-285	19	16	some	some	DET
ecletica-285	19	17	other	other	ADJ
ecletica-285	19	18	zinc	zinc	NOUN
ecletica-285	19	19	-	-	PUNCT
ecletica-285	19	20	proteins	protein	NOUN
ecletica-285	19	21	,	,	PUNCT
ecletica-285	19	22	as	as	ADP
ecletica-285	19	23	the	the	DET
ecletica-285	19	24	thermolysin	thermolysin	NOUN
ecletica-285	19	25	,	,	PUNCT
ecletica-285	19	26	in	in	ADP
ecletica-285	19	27	which	which	PRON
ecletica-285	19	28	the	the	DET
ecletica-285	19	29	third	third	ADJ
ecletica-285	19	30	bond	bond	NOUN
ecletica-285	19	31	involves	involve	VERB
ecletica-285	19	32	a	a	DET
ecletica-285	19	33	residue	residue	NOUN
ecletica-285	19	34	of	of	ADP
ecletica-285	19	35	glu	glu	NOUN
ecletica-285	19	36	separated	separate	VERB
ecletica-285	19	37	from	from	ADP
ecletica-285	19	38	his	his	PRON
ecletica-285	19	39	by	by	ADP
ecletica-285	19	40	19	19	NUM
ecletica-285	19	41	amino	amino	ADJ
ecletica-285	19	42	acids	acid	NOUN
ecletica-285	19	43	residues	residue	NOUN
ecletica-285	19	44	[	[	X
ecletica-285	19	45	1	1	NUM
ecletica-285	19	46	]	]	PUNCT
ecletica-285	19	47	.	.	PUNCT
ecletica-285	20	1	the	the	DET
ecletica-285	20	2	activation	activation	NOUN
ecletica-285	20	3	of	of	ADP
ecletica-285	20	4	the	the	DET
ecletica-285	20	5	matrix	matrix	NOUN
ecletica-285	20	6	metalloproteinases	metalloproteinase	NOUN
ecletica-285	20	7	,	,	PUNCT
ecletica-285	20	8	that	that	ADV
ecletica-285	20	9	is	is	ADV
ecletica-285	20	10	,	,	PUNCT
ecletica-285	20	11	the	the	DET
ecletica-285	20	12	transformation	transformation	NOUN
ecletica-285	20	13	of	of	ADP
ecletica-285	20	14	zymogen	zymogen	NOUN
ecletica-285	20	15	into	into	ADP
ecletica-285	20	16	active	active	ADJ
ecletica-285	20	17	enzyme	enzyme	NOUN
ecletica-285	20	18	,	,	PUNCT
ecletica-285	20	19	involves	involve	VERB
ecletica-285	20	20	the	the	DET
ecletica-285	20	21	change	change	NOUN
ecletica-285	20	22	of	of	ADP
ecletica-285	20	23	the	the	DET
ecletica-285	20	24	coordination	coordination	NOUN
ecletica-285	20	25	of	of	ADP
ecletica-285	20	26	the	the	DET
ecletica-285	20	27	zinc	zinc	NOUN
ecletica-285	20	28	with	with	ADP
ecletica-285	20	29	the	the	DET
ecletica-285	20	30	sulphydril	sulphydril	NOUN
ecletica-285	20	31	group	group	NOUN
ecletica-285	20	32	of	of	ADP
ecletica-285	20	33	a	a	DET
ecletica-285	20	34	ecl	ecl	PROPN
ecletica-285	20	35	.	.	PROPN
ecletica-285	20	36	quím	quím	PROPN
ecletica-285	20	37	.	.	PUNCT
ecletica-285	21	1	,	,	PUNCT
ecletica-285	21	2	são	são	PROPN
ecletica-285	21	3	paulo	paulo	PROPN
ecletica-285	21	4	,	,	PUNCT
ecletica-285	21	5	34(4	34(4	NUM
ecletica-285	21	6	):	):	PUNCT
ecletica-285	21	7	87	87	NUM
ecletica-285	21	8	102	102	NUM
ecletica-285	21	9	,	,	PUNCT
ecletica-285	21	10	2009	2009	NUM
ecletica-285	21	11	artigo	artigo	NOUN
ecletica-285	21	12	/	/	SYM
ecletica-285	21	13	article	article	NOUN
ecletica-285	21	14	ecl	ecl	PROPN
ecletica-285	21	15	.	.	PROPN
ecletica-285	21	16	quím	quím	PROPN
ecletica-285	21	17	.	.	PUNCT
ecletica-285	21	18	,	,	PUNCT
ecletica-285	21	19	são	são	PROPN
ecletica-285	21	20	paulo	paulo	PROPN
ecletica-285	21	21	,	,	PUNCT
ecletica-285	21	22	34(4	34(4	NUM
ecletica-285	21	23	):	):	PUNCT
ecletica-285	21	24	87	87	NUM
ecletica-285	21	25	102	102	NUM
ecletica-285	21	26	,	,	PUNCT
ecletica-285	21	27	200988	200988	NUM
ecletica-285	21	28	artigo	artigo	PROPN
ecletica-285	21	29	article	article	NOUN
ecletica-285	21	30	cystein	cystein	ADJ
ecletica-285	21	31	residue	residue	NOUN
ecletica-285	21	32	,	,	PUNCT
ecletica-285	21	33	for	for	ADP
ecletica-285	21	34	water	water	NOUN
ecletica-285	21	35	,	,	PUNCT
ecletica-285	21	36	which	which	PRON
ecletica-285	21	37	turns	turn	VERB
ecletica-285	21	38	the	the	DET
ecletica-285	21	39	fourth	fourth	ADJ
ecletica-285	21	40	point	point	NOUN
ecletica-285	21	41	of	of	ADP
ecletica-285	21	42	coordination	coordination	NOUN
ecletica-285	21	43	of	of	ADP
ecletica-285	21	44	that	that	DET
ecletica-285	21	45	metal	metal	NOUN
ecletica-285	22	1	[	[	X
ecletica-285	22	2	3	3	NUM
ecletica-285	22	3	,	,	PUNCT
ecletica-285	22	4	5	5	NUM
ecletica-285	22	5	]	]	PUNCT
ecletica-285	22	6	.	.	PUNCT
ecletica-285	23	1	different	different	ADJ
ecletica-285	23	2	causes	cause	NOUN
ecletica-285	23	3	that	that	PRON
ecletica-285	23	4	result	result	VERB
ecletica-285	23	5	in	in	ADP
ecletica-285	23	6	the	the	DET
ecletica-285	23	7	contact	contact	NOUN
ecletica-285	23	8	loss	loss	NOUN
ecletica-285	23	9	between	between	ADP
ecletica-285	23	10	cystein	cystein	ADJ
ecletica-285	23	11	and	and	CCONJ
ecletica-285	23	12	zn	zn	PROPN
ecletica-285	23	13	can	can	AUX
ecletica-285	23	14	activate	activate	VERB
ecletica-285	23	15	the	the	DET
ecletica-285	23	16	enzyme	enzyme	NOUN
ecletica-285	23	17	.	.	PUNCT
ecletica-285	24	1	in	in	ADP
ecletica-285	24	2	vivo	vivo	NOUN
ecletica-285	24	3	this	this	DET
ecletica-285	24	4	activation	activation	NOUN
ecletica-285	24	5	is	be	AUX
ecletica-285	24	6	mediated	mediate	VERB
ecletica-285	24	7	by	by	ADP
ecletica-285	24	8	plasmin	plasmin	NOUN
ecletica-285	24	9	.	.	PUNCT
ecletica-285	25	1	the	the	DET
ecletica-285	25	2	inhibition	inhibition	NOUN
ecletica-285	25	3	of	of	ADP
ecletica-285	25	4	mmps	mmp	NOUN
ecletica-285	25	5	is	be	AUX
ecletica-285	25	6	the	the	DET
ecletica-285	25	7	opposite	opposite	ADJ
ecletica-285	25	8	effect	effect	NOUN
ecletica-285	25	9	that	that	PRON
ecletica-285	25	10	modulates	modulate	VERB
ecletica-285	25	11	the	the	DET
ecletica-285	25	12	activity	activity	NOUN
ecletica-285	25	13	of	of	ADP
ecletica-285	25	14	mmps	mmp	NOUN
ecletica-285	25	15	in	in	ADP
ecletica-285	25	16	the	the	DET
ecletica-285	25	17	normal	normal	ADJ
ecletica-285	25	18	organism	organism	NOUN
ecletica-285	25	19	.	.	PUNCT
ecletica-285	26	1	in	in	ADP
ecletica-285	26	2	nature	nature	NOUN
ecletica-285	26	3	this	this	DET
ecletica-285	26	4	role	role	NOUN
ecletica-285	26	5	is	be	AUX
ecletica-285	26	6	played	play	VERB
ecletica-285	26	7	by	by	ADP
ecletica-285	26	8	a	a	DET
ecletica-285	26	9	family	family	NOUN
ecletica-285	26	10	of	of	ADP
ecletica-285	26	11	inhibitors	inhibitor	NOUN
ecletica-285	26	12	known	know	VERB
ecletica-285	26	13	as	as	ADP
ecletica-285	26	14	tissue	tissue	NOUN
ecletica-285	26	15	inhibitors	inhibitor	NOUN
ecletica-285	26	16	of	of	ADP
ecletica-285	26	17	metalloproteinases	metalloproteinase	NOUN
ecletica-285	26	18	,	,	PUNCT
ecletica-285	26	19	timp	timp	NOUN
ecletica-285	26	20	,	,	PUNCT
ecletica-285	26	21	that	that	PRON
ecletica-285	26	22	are	be	AUX
ecletica-285	26	23	proteins	protein	NOUN
ecletica-285	26	24	that	that	PRON
ecletica-285	26	25	link	link	VERB
ecletica-285	26	26	to	to	ADP
ecletica-285	26	27	several	several	ADJ
ecletica-285	26	28	matrixins	matrixin	NOUN
ecletica-285	26	29	,	,	PUNCT
ecletica-285	26	30	not	not	PART
ecletica-285	26	31	very	very	ADV
ecletica-285	26	32	selectively	selectively	ADV
ecletica-285	26	33	,	,	PUNCT
ecletica-285	26	34	inhibiting	inhibit	VERB
ecletica-285	26	35	them	they	PRON
ecletica-285	26	36	.	.	PUNCT
ecletica-285	27	1	besides	besides	SCONJ
ecletica-285	27	2	the	the	DET
ecletica-285	27	3	tissue	tissue	NOUN
ecletica-285	27	4	inhibitors	inhibitor	NOUN
ecletica-285	27	5	,	,	PUNCT
ecletica-285	27	6	the	the	DET
ecletica-285	27	7	human	human	ADJ
ecletica-285	27	8	plasma	plasma	NOUN
ecletica-285	27	9	α2	α2	PROPN
ecletica-285	27	10	-	-	PUNCT
ecletica-285	27	11	macroglobulin	macroglobulin	PROPN
ecletica-285	27	12	and	and	CCONJ
ecletica-285	27	13	related	related	ADJ
ecletica-285	27	14	proteins	protein	NOUN
ecletica-285	27	15	of	of	ADP
ecletica-285	27	16	the	the	DET
ecletica-285	27	17	plasma	plasma	NOUN
ecletica-285	27	18	of	of	ADP
ecletica-285	27	19	other	other	ADJ
ecletica-285	27	20	mammals	mammal	NOUN
ecletica-285	27	21	and	and	CCONJ
ecletica-285	27	22	of	of	ADP
ecletica-285	27	23	the	the	DET
ecletica-285	27	24	chicken	chicken	NOUN
ecletica-285	27	25	egg	egg	NOUN
ecletica-285	27	26	also	also	ADV
ecletica-285	27	27	have	have	VERB
ecletica-285	27	28	inhibiting	inhibit	VERB
ecletica-285	27	29	effect	effect	NOUN
ecletica-285	27	30	[	[	X
ecletica-285	27	31	3	3	NUM
ecletica-285	27	32	]	]	PUNCT
ecletica-285	27	33	.	.	PUNCT
ecletica-285	28	1	besides	besides	SCONJ
ecletica-285	28	2	the	the	DET
ecletica-285	28	3	natural	natural	ADJ
ecletica-285	28	4	inhibitors	inhibitor	NOUN
ecletica-285	28	5	,	,	PUNCT
ecletica-285	28	6	synthetic	synthetic	ADJ
ecletica-285	28	7	inhibitors	inhibitor	NOUN
ecletica-285	28	8	have	have	AUX
ecletica-285	28	9	been	be	AUX
ecletica-285	28	10	prepared	prepare	VERB
ecletica-285	28	11	in	in	ADP
ecletica-285	28	12	the	the	DET
ecletica-285	28	13	sense	sense	NOUN
ecletica-285	28	14	of	of	ADP
ecletica-285	28	15	obtaining	obtain	VERB
ecletica-285	28	16	drugs	drug	NOUN
ecletica-285	28	17	for	for	ADP
ecletica-285	28	18	treatment	treatment	NOUN
ecletica-285	28	19	of	of	ADP
ecletica-285	28	20	pathological	pathological	ADJ
ecletica-285	28	21	processes	process	NOUN
ecletica-285	28	22	mediated	mediate	VERB
ecletica-285	28	23	by	by	ADP
ecletica-285	28	24	such	such	ADJ
ecletica-285	28	25	enzymes	enzyme	NOUN
ecletica-285	28	26	,	,	PUNCT
ecletica-285	28	27	or	or	CCONJ
ecletica-285	28	28	when	when	SCONJ
ecletica-285	28	29	an	an	DET
ecletica-285	28	30	unbalance	unbalance	NOUN
ecletica-285	28	31	between	between	ADP
ecletica-285	28	32	activation	activation	NOUN
ecletica-285	28	33	and	and	CCONJ
ecletica-285	28	34	inhibition	inhibition	NOUN
ecletica-285	28	35	of	of	ADP
ecletica-285	28	36	mmps	mmp	NOUN
ecletica-285	28	37	occurs	occur	VERB
ecletica-285	28	38	.	.	PUNCT
ecletica-285	29	1	among	among	ADP
ecletica-285	29	2	such	such	ADJ
ecletica-285	29	3	pathologies	pathology	NOUN
ecletica-285	29	4	we	we	PRON
ecletica-285	29	5	can	can	AUX
ecletica-285	29	6	mention	mention	VERB
ecletica-285	29	7	certain	certain	ADJ
ecletica-285	29	8	rheumatic	rheumatic	ADJ
ecletica-285	29	9	processes	process	NOUN
ecletica-285	29	10	(	(	PUNCT
ecletica-285	29	11	osteoarthritis	osteoarthritis	NOUN
ecletica-285	29	12	and	and	CCONJ
ecletica-285	29	13	rheumatoid	rheumatoid	VERB
ecletica-285	29	14	arthritis	arthritis	NOUN
ecletica-285	29	15	)	)	PUNCT
ecletica-285	29	16	,	,	PUNCT
ecletica-285	29	17	tumor	tumor	NOUN
ecletica-285	29	18	invasion	invasion	NOUN
ecletica-285	29	19	and	and	CCONJ
ecletica-285	29	20	metastasis	metastasis	NOUN
ecletica-285	29	21	,	,	PUNCT
ecletica-285	29	22	and	and	CCONJ
ecletica-285	29	23	periodontal	periodontal	ADJ
ecletica-285	29	24	disease	disease	NOUN
ecletica-285	29	25	.	.	PUNCT
ecletica-285	30	1	unfortunately	unfortunately	ADV
ecletica-285	30	2	,	,	PUNCT
ecletica-285	30	3	the	the	DET
ecletica-285	30	4	first	first	ADJ
ecletica-285	30	5	generation	generation	NOUN
ecletica-285	30	6	of	of	ADP
ecletica-285	30	7	those	those	DET
ecletica-285	30	8	drugs	drug	NOUN
ecletica-285	30	9	,	,	PUNCT
ecletica-285	30	10	already	already	ADV
ecletica-285	30	11	submitted	submit	VERB
ecletica-285	30	12	to	to	ADP
ecletica-285	30	13	clinical	clinical	ADJ
ecletica-285	30	14	trials	trial	NOUN
ecletica-285	30	15	,	,	PUNCT
ecletica-285	30	16	did	do	AUX
ecletica-285	30	17	not	not	PART
ecletica-285	30	18	result	result	VERB
ecletica-285	30	19	in	in	ADP
ecletica-285	30	20	promising	promise	VERB
ecletica-285	30	21	drugs	drug	NOUN
ecletica-285	30	22	.	.	PUNCT
ecletica-285	31	1	the	the	DET
ecletica-285	31	2	main	main	ADJ
ecletica-285	31	3	problem	problem	NOUN
ecletica-285	31	4	is	be	AUX
ecletica-285	31	5	the	the	DET
ecletica-285	31	6	lack	lack	NOUN
ecletica-285	31	7	of	of	ADP
ecletica-285	31	8	specificity	specificity	NOUN
ecletica-285	31	9	,	,	PUNCT
ecletica-285	31	10	difficulty	difficulty	NOUN
ecletica-285	31	11	that	that	PRON
ecletica-285	31	12	comes	come	VERB
ecletica-285	31	13	from	from	ADP
ecletica-285	31	14	the	the	DET
ecletica-285	31	15	similarity	similarity	NOUN
ecletica-285	31	16	among	among	ADP
ecletica-285	31	17	the	the	DET
ecletica-285	31	18	active	active	ADJ
ecletica-285	31	19	sites	site	NOUN
ecletica-285	31	20	of	of	ADP
ecletica-285	31	21	the	the	DET
ecletica-285	31	22	different	different	ADJ
ecletica-285	31	23	conjunctive	conjunctive	ADJ
ecletica-285	31	24	matrix	matrix	NOUN
ecletica-285	31	25	metalloproteinases	metalloproteinase	NOUN
ecletica-285	31	26	.	.	PUNCT
ecletica-285	32	1	the	the	DET
ecletica-285	32	2	search	search	NOUN
ecletica-285	32	3	of	of	ADP
ecletica-285	32	4	effective	effective	ADJ
ecletica-285	32	5	and	and	CCONJ
ecletica-285	32	6	selective	selective	ADJ
ecletica-285	32	7	synthetic	synthetic	ADJ
ecletica-285	32	8	inhibitors	inhibitor	NOUN
ecletica-285	32	9	has	have	AUX
ecletica-285	32	10	stimulated	stimulate	VERB
ecletica-285	32	11	the	the	DET
ecletica-285	32	12	study	study	NOUN
ecletica-285	32	13	of	of	ADP
ecletica-285	32	14	the	the	DET
ecletica-285	32	15	structure	structure	NOUN
ecletica-285	32	16	of	of	ADP
ecletica-285	32	17	matrix	matrix	NOUN
ecletica-285	32	18	metalloproteinases	metalloproteinase	NOUN
ecletica-285	32	19	of	of	ADP
ecletica-285	32	20	mammals	mammal	NOUN
ecletica-285	32	21	.	.	PUNCT
ecletica-285	33	1	since	since	SCONJ
ecletica-285	33	2	1993	1993	NUM
ecletica-285	33	3	different	different	ADJ
ecletica-285	33	4	mmp	mmp	PROPN
ecletica-285	33	5	structures	structure	NOUN
ecletica-285	33	6	have	have	AUX
ecletica-285	33	7	been	be	AUX
ecletica-285	33	8	determined	determine	VERB
ecletica-285	33	9	by	by	ADP
ecletica-285	33	10	x	x	NOUN
ecletica-285	33	11	-	-	NOUN
ecletica-285	33	12	ray	ray	NOUN
ecletica-285	33	13	diffraction	diffraction	NOUN
ecletica-285	33	14	and	and	CCONJ
ecletica-285	33	15	nmr	nmr	NOUN
ecletica-285	33	16	spectroscopy	spectroscopy	NOUN
ecletica-285	33	17	,	,	PUNCT
ecletica-285	33	18	free	free	ADJ
ecletica-285	33	19	or	or	CCONJ
ecletica-285	33	20	bound	bind	VERB
ecletica-285	33	21	to	to	ADP
ecletica-285	33	22	inhibitors	inhibitor	NOUN
ecletica-285	33	23	[	[	X
ecletica-285	33	24	2,618	2,618	NUM
ecletica-285	33	25	]	]	PUNCT
ecletica-285	33	26	.	.	PUNCT
ecletica-285	34	1	the	the	DET
ecletica-285	34	2	zinc	zinc	NOUN
ecletica-285	34	3	ion	ion	NOUN
ecletica-285	34	4	in	in	ADP
ecletica-285	34	5	the	the	DET
ecletica-285	34	6	active	active	ADJ
ecletica-285	34	7	site	site	NOUN
ecletica-285	34	8	of	of	ADP
ecletica-285	34	9	mmps	mmp	NOUN
ecletica-285	34	10	is	be	AUX
ecletica-285	34	11	coordinated	coordinate	VERB
ecletica-285	34	12	by	by	ADP
ecletica-285	34	13	at	at	ADV
ecletica-285	34	14	least	least	ADV
ecletica-285	34	15	two	two	NUM
ecletica-285	34	16	histidine	histidine	ADJ
ecletica-285	34	17	residues	residue	NOUN
ecletica-285	34	18	,	,	PUNCT
ecletica-285	34	19	of	of	ADP
ecletica-285	34	20	numbers	number	NOUN
ecletica-285	34	21	218	218	NUM
ecletica-285	34	22	and	and	CCONJ
ecletica-285	34	23	222	222	NUM
ecletica-285	34	24	,	,	PUNCT
ecletica-285	34	25	through	through	ADP
ecletica-285	34	26	one	one	NUM
ecletica-285	34	27	of	of	ADP
ecletica-285	34	28	the	the	DET
ecletica-285	34	29	atoms	atom	NOUN
ecletica-285	34	30	of	of	ADP
ecletica-285	34	31	nitrogen	nitrogen	NOUN
ecletica-285	34	32	of	of	ADP
ecletica-285	34	33	the	the	DET
ecletica-285	34	34	imidazol	imidazol	ADJ
ecletica-285	34	35	ring	ring	NOUN
ecletica-285	34	36	.	.	PUNCT
ecletica-285	35	1	browner	brown	ADJ
ecletica-285	35	2	et	et	PROPN
ecletica-285	35	3	al	al	PROPN
ecletica-285	35	4	.	.	PUNCT
ecletica-285	36	1	[	[	X
ecletica-285	36	2	2	2	NUM
ecletica-285	36	3	]	]	PUNCT
ecletica-285	36	4	demonstrated	demonstrate	VERB
ecletica-285	36	5	that	that	SCONJ
ecletica-285	36	6	,	,	PUNCT
ecletica-285	36	7	for	for	ADP
ecletica-285	36	8	the	the	DET
ecletica-285	36	9	case	case	NOUN
ecletica-285	36	10	of	of	ADP
ecletica-285	36	11	the	the	DET
ecletica-285	36	12	matridemonstrated	matridemonstrate	VERB
ecletica-285	36	13	that	that	SCONJ
ecletica-285	36	14	,	,	PUNCT
ecletica-285	36	15	for	for	ADP
ecletica-285	36	16	the	the	DET
ecletica-285	36	17	case	case	NOUN
ecletica-285	36	18	of	of	ADP
ecletica-285	36	19	the	the	DET
ecletica-285	36	20	matrilysin	matrilysin	NOUN
ecletica-285	36	21	,	,	PUNCT
ecletica-285	36	22	such	such	ADJ
ecletica-285	36	23	histidine	histidine	ADJ
ecletica-285	36	24	residues	residue	NOUN
ecletica-285	36	25	and	and	CCONJ
ecletica-285	36	26	a	a	DET
ecletica-285	36	27	third	third	ADJ
ecletica-285	36	28	,	,	PUNCT
ecletica-285	36	29	the	the	DET
ecletica-285	36	30	228	228	NUM
ecletica-285	36	31	,	,	PUNCT
ecletica-285	36	32	are	be	AUX
ecletica-285	36	33	involved	involve	VERB
ecletica-285	36	34	in	in	ADP
ecletica-285	36	35	the	the	DET
ecletica-285	36	36	coordination	coordination	NOUN
ecletica-285	36	37	of	of	ADP
ecletica-285	36	38	the	the	DET
ecletica-285	36	39	zinc	zinc	NOUN
ecletica-285	36	40	of	of	ADP
ecletica-285	36	41	the	the	DET
ecletica-285	36	42	catalytic	catalytic	ADJ
ecletica-285	36	43	site	site	NOUN
ecletica-285	36	44	,	,	PUNCT
ecletica-285	36	45	through	through	ADP
ecletica-285	36	46	nε	nε	NOUN
ecletica-285	36	47	of	of	ADP
ecletica-285	36	48	the	the	DET
ecletica-285	36	49	ring	ring	NOUN
ecletica-285	36	50	.	.	PUNCT
ecletica-285	37	1	a	a	DET
ecletica-285	37	2	second	second	ADJ
ecletica-285	37	3	ion	ion	NOUN
ecletica-285	37	4	zinc	zinc	NOUN
ecletica-285	37	5	,	,	PUNCT
ecletica-285	37	6	this	this	DET
ecletica-285	37	7	one	one	NOUN
ecletica-285	37	8	with	with	ADP
ecletica-285	37	9	structural	structural	ADJ
ecletica-285	37	10	function	function	NOUN
ecletica-285	37	11	,	,	PUNCT
ecletica-285	37	12	is	be	AUX
ecletica-285	37	13	coordinated	coordinate	VERB
ecletica-285	37	14	by	by	ADP
ecletica-285	37	15	other	other	ADJ
ecletica-285	37	16	three	three	NUM
ecletica-285	37	17	histidine	histidine	NOUN
ecletica-285	37	18	residues	residue	NOUN
ecletica-285	37	19	and	and	CCONJ
ecletica-285	37	20	one	one	NUM
ecletica-285	37	21	of	of	ADP
ecletica-285	37	22	glutamic	glutamic	ADJ
ecletica-285	37	23	acid	acid	NOUN
ecletica-285	37	24	.	.	PUNCT
ecletica-285	38	1	similar	similar	ADJ
ecletica-285	38	2	situation	situation	NOUN
ecletica-285	38	3	takes	take	VERB
ecletica-285	38	4	place	place	NOUN
ecletica-285	38	5	in	in	ADP
ecletica-285	38	6	the	the	DET
ecletica-285	38	7	stromelysin	stromelysin	NOUN
ecletica-285	38	8	1	1	NUM
ecletica-285	38	9	,	,	PUNCT
ecletica-285	38	10	where	where	SCONJ
ecletica-285	38	11	the	the	DET
ecletica-285	38	12	catalytic	catalytic	ADJ
ecletica-285	38	13	zinc	zinc	NOUN
ecletica-285	38	14	is	be	AUX
ecletica-285	38	15	coordinated	coordinate	VERB
ecletica-285	38	16	by	by	ADP
ecletica-285	38	17	his-201	his-201	NOUN
ecletica-285	38	18	,	,	PUNCT
ecletica-285	38	19	-205	-205	NOUN
ecletica-285	38	20	,	,	PUNCT
ecletica-285	38	21	and	and	CCONJ
ecletica-285	38	22	-211	-211	PROPN
ecletica-285	38	23	,	,	PUNCT
ecletica-285	38	24	and	and	CCONJ
ecletica-285	38	25	the	the	DET
ecletica-285	38	26	structural	structural	ADJ
ecletica-285	38	27	zinc	zinc	NOUN
ecletica-285	38	28	by	by	ADP
ecletica-285	38	29	his-151	his-151	NOUN
ecletica-285	38	30	,	,	PUNCT
ecletica-285	38	31	-166	-166	PROPN
ecletica-285	38	32	,	,	PUNCT
ecletica-285	38	33	and	and	CCONJ
ecletica-285	38	34	-179	-179	NOUN
ecletica-285	39	1	[	[	X
ecletica-285	39	2	14	14	NUM
ecletica-285	39	3	]	]	PUNCT
ecletica-285	39	4	.	.	PUNCT
ecletica-285	40	1	to	to	PART
ecletica-285	40	2	summarize	summarize	VERB
ecletica-285	40	3	,	,	PUNCT
ecletica-285	40	4	metalloproteases	metalloprotease	NOUN
ecletica-285	40	5	from	from	ADP
ecletica-285	40	6	connective	connective	ADJ
ecletica-285	40	7	tissue	tissue	NOUN
ecletica-285	40	8	of	of	ADP
ecletica-285	40	9	mammals	mammal	NOUN
ecletica-285	40	10	,	,	PUNCT
ecletica-285	40	11	mmps	mmp	NOUN
ecletica-285	40	12	,	,	PUNCT
ecletica-285	40	13	have	have	AUX
ecletica-285	40	14	in	in	ADP
ecletica-285	40	15	common	common	ADJ
ecletica-285	40	16	two	two	NUM
ecletica-285	40	17	ions	ion	NOUN
ecletica-285	40	18	of	of	ADP
ecletica-285	40	19	zinc	zinc	NOUN
ecletica-285	40	20	,	,	PUNCT
ecletica-285	40	21	one	one	NUM
ecletica-285	40	22	located	locate	VERB
ecletica-285	40	23	in	in	ADP
ecletica-285	40	24	the	the	DET
ecletica-285	40	25	enzyme	enzyme	NOUN
ecletica-285	40	26	active	active	ADJ
ecletica-285	40	27	site	site	NOUN
ecletica-285	40	28	,	,	PUNCT
ecletica-285	40	29	involved	involve	VERB
ecletica-285	40	30	in	in	ADP
ecletica-285	40	31	the	the	DET
ecletica-285	40	32	catalytic	catalytic	ADJ
ecletica-285	40	33	process	process	NOUN
ecletica-285	40	34	,	,	PUNCT
ecletica-285	40	35	and	and	CCONJ
ecletica-285	40	36	the	the	DET
ecletica-285	40	37	other	other	ADJ
ecletica-285	40	38	with	with	ADP
ecletica-285	40	39	structural	structural	ADJ
ecletica-285	40	40	function	function	NOUN
ecletica-285	40	41	,	,	PUNCT
ecletica-285	40	42	similar	similar	ADJ
ecletica-285	40	43	to	to	ADP
ecletica-285	40	44	calcium	calcium	NOUN
ecletica-285	40	45	ions	ion	NOUN
ecletica-285	40	46	in	in	ADP
ecletica-285	40	47	these	these	DET
ecletica-285	40	48	enzymes	enzyme	NOUN
ecletica-285	40	49	.	.	PUNCT
ecletica-285	41	1	the	the	DET
ecletica-285	41	2	catalytic	catalytic	ADJ
ecletica-285	41	3	zinc	zinc	NOUN
ecletica-285	41	4	ion	ion	NOUN
ecletica-285	41	5	binds	bind	VERB
ecletica-285	41	6	to	to	ADP
ecletica-285	41	7	three	three	NUM
ecletica-285	41	8	histidine	histidine	ADJ
ecletica-285	41	9	residues	residue	NOUN
ecletica-285	41	10	and	and	CCONJ
ecletica-285	41	11	,	,	PUNCT
ecletica-285	41	12	in	in	ADP
ecletica-285	41	13	the	the	DET
ecletica-285	41	14	active	active	ADJ
ecletica-285	41	15	enzymes	enzyme	NOUN
ecletica-285	41	16	,	,	PUNCT
ecletica-285	41	17	to	to	ADP
ecletica-285	41	18	a	a	DET
ecletica-285	41	19	molecule	molecule	NOUN
ecletica-285	41	20	of	of	ADP
ecletica-285	41	21	water	water	NOUN
ecletica-285	41	22	.	.	PUNCT
ecletica-285	42	1	the	the	DET
ecletica-285	42	2	other	other	ADJ
ecletica-285	42	3	zinc	zinc	NOUN
ecletica-285	42	4	ion	ion	NOUN
ecletica-285	42	5	also	also	ADV
ecletica-285	42	6	coordinates	coordinate	VERB
ecletica-285	42	7	to	to	ADP
ecletica-285	42	8	three	three	NUM
ecletica-285	42	9	other	other	ADJ
ecletica-285	42	10	residues	residue	NOUN
ecletica-285	42	11	of	of	ADP
ecletica-285	42	12	histidine	histidine	NOUN
ecletica-285	42	13	and	and	CCONJ
ecletica-285	42	14	to	to	ADP
ecletica-285	42	15	a	a	DET
ecletica-285	42	16	fourth	fourth	ADJ
ecletica-285	42	17	residue	residue	NOUN
ecletica-285	42	18	of	of	ADP
ecletica-285	42	19	another	another	DET
ecletica-285	42	20	amino	amino	NOUN
ecletica-285	42	21	acid	acid	NOUN
ecletica-285	42	22	,	,	PUNCT
ecletica-285	42	23	which	which	PRON
ecletica-285	42	24	depends	depend	VERB
ecletica-285	42	25	on	on	ADP
ecletica-285	42	26	the	the	DET
ecletica-285	42	27	nature	nature	NOUN
ecletica-285	42	28	of	of	ADP
ecletica-285	42	29	the	the	DET
ecletica-285	42	30	enzyme	enzyme	NOUN
ecletica-285	42	31	.	.	PUNCT
ecletica-285	43	1	the	the	DET
ecletica-285	43	2	active	active	ADJ
ecletica-285	43	3	site	site	NOUN
ecletica-285	43	4	zinc	zinc	NOUN
ecletica-285	43	5	in	in	ADP
ecletica-285	43	6	the	the	DET
ecletica-285	43	7	mmps	mmp	NOUN
ecletica-285	43	8	acts	act	VERB
ecletica-285	43	9	as	as	ADP
ecletica-285	43	10	a	a	DET
ecletica-285	43	11	lewis	lewis	PROPN
ecletica-285	43	12	acid	acid	NOUN
ecletica-285	43	13	,	,	PUNCT
ecletica-285	43	14	since	since	SCONJ
ecletica-285	43	15	it	it	PRON
ecletica-285	43	16	is	be	AUX
ecletica-285	43	17	a	a	DET
ecletica-285	43	18	good	good	ADJ
ecletica-285	43	19	electron	electron	NOUN
ecletica-285	43	20	acceptor	acceptor	NOUN
ecletica-285	43	21	.	.	PUNCT
ecletica-285	44	1	thus	thus	ADV
ecletica-285	44	2	,	,	PUNCT
ecletica-285	44	3	it	it	PRON
ecletica-285	44	4	is	be	AUX
ecletica-285	44	5	able	able	ADJ
ecletica-285	44	6	to	to	PART
ecletica-285	44	7	polarize	polarize	VERB
ecletica-285	44	8	a	a	DET
ecletica-285	44	9	binding	bind	VERB
ecletica-285	44	10	group	group	NOUN
ecletica-285	44	11	of	of	ADP
ecletica-285	44	12	the	the	DET
ecletica-285	44	13	substrate	substrate	NOUN
ecletica-285	44	14	and	and	CCONJ
ecletica-285	44	15	,	,	PUNCT
ecletica-285	44	16	as	as	ADP
ecletica-285	44	17	a	a	DET
ecletica-285	44	18	result	result	NOUN
ecletica-285	44	19	,	,	PUNCT
ecletica-285	44	20	if	if	SCONJ
ecletica-285	44	21	this	this	DET
ecletica-285	44	22	group	group	NOUN
ecletica-285	44	23	is	be	AUX
ecletica-285	44	24	a	a	DET
ecletica-285	44	25	base	base	NOUN
ecletica-285	44	26	,	,	PUNCT
ecletica-285	44	27	increases	increase	VERB
ecletica-285	44	28	its	its	PRON
ecletica-285	44	29	nucleophilic	nucleophilic	ADJ
ecletica-285	44	30	power	power	NOUN
ecletica-285	44	31	.	.	PUNCT
ecletica-285	45	1	on	on	ADP
ecletica-285	45	2	the	the	DET
ecletica-285	45	3	other	other	ADJ
ecletica-285	45	4	hand	hand	NOUN
ecletica-285	45	5	,	,	PUNCT
ecletica-285	45	6	acting	act	VERB
ecletica-285	45	7	as	as	ADP
ecletica-285	45	8	an	an	DET
ecletica-285	45	9	acid	acid	NOUN
ecletica-285	45	10	,	,	PUNCT
ecletica-285	45	11	increases	increase	VERB
ecletica-285	45	12	the	the	DET
ecletica-285	45	13	ability	ability	NOUN
ecletica-285	45	14	of	of	ADP
ecletica-285	45	15	a	a	DET
ecletica-285	45	16	group	group	NOUN
ecletica-285	45	17	connected	connect	VERB
ecletica-285	45	18	to	to	ADP
ecletica-285	45	19	it	it	PRON
ecletica-285	45	20	to	to	PART
ecletica-285	45	21	suffer	suffer	VERB
ecletica-285	45	22	the	the	DET
ecletica-285	45	23	attack	attack	NOUN
ecletica-285	45	24	of	of	ADP
ecletica-285	45	25	a	a	DET
ecletica-285	45	26	base	base	NOUN
ecletica-285	45	27	.	.	PUNCT
ecletica-285	46	1	an	an	DET
ecletica-285	46	2	example	example	NOUN
ecletica-285	46	3	of	of	ADP
ecletica-285	46	4	the	the	DET
ecletica-285	46	5	first	first	ADJ
ecletica-285	46	6	type	type	NOUN
ecletica-285	46	7	is	be	AUX
ecletica-285	46	8	the	the	DET
ecletica-285	46	9	molecule	molecule	NOUN
ecletica-285	46	10	of	of	ADP
ecletica-285	46	11	water	water	NOUN
ecletica-285	46	12	binding	bind	VERB
ecletica-285	46	13	to	to	ADP
ecletica-285	46	14	zinc	zinc	NOUN
ecletica-285	46	15	in	in	ADP
ecletica-285	46	16	the	the	DET
ecletica-285	46	17	active	active	ADJ
ecletica-285	46	18	enzyme	enzyme	NOUN
ecletica-285	46	19	,	,	PUNCT
ecletica-285	46	20	which	which	PRON
ecletica-285	46	21	dissociates	dissociate	VERB
ecletica-285	46	22	under	under	ADP
ecletica-285	46	23	the	the	DET
ecletica-285	46	24	polarizing	polarizing	NOUN
ecletica-285	46	25	effect	effect	NOUN
ecletica-285	46	26	of	of	ADP
ecletica-285	46	27	zn2	zn2	PROPN
ecletica-285	46	28	+	+	PROPN
ecletica-285	46	29	,	,	PUNCT
ecletica-285	46	30	even	even	ADV
ecletica-285	46	31	in	in	ADP
ecletica-285	46	32	environments	environment	NOUN
ecletica-285	46	33	with	with	ADP
ecletica-285	46	34	ph	ph	ADJ
ecletica-285	46	35	values	value	NOUN
ecletica-285	46	36	not	not	PART
ecletica-285	46	37	very	very	ADV
ecletica-285	46	38	high	high	ADJ
ecletica-285	46	39	,	,	PUNCT
ecletica-285	46	40	generating	generate	VERB
ecletica-285	46	41	a	a	DET
ecletica-285	46	42	hydroxyl	hydroxyl	NOUN
ecletica-285	46	43	able	able	ADJ
ecletica-285	46	44	to	to	PART
ecletica-285	46	45	attack	attack	VERB
ecletica-285	46	46	other	other	ADJ
ecletica-285	46	47	molecules	molecule	NOUN
ecletica-285	46	48	.	.	PUNCT
ecletica-285	47	1	this	this	PRON
ecletica-285	47	2	is	be	AUX
ecletica-285	47	3	the	the	DET
ecletica-285	47	4	mechanism	mechanism	NOUN
ecletica-285	47	5	of	of	ADP
ecletica-285	47	6	action	action	NOUN
ecletica-285	47	7	suggested	suggest	VERB
ecletica-285	47	8	for	for	ADP
ecletica-285	47	9	the	the	DET
ecletica-285	47	10	carbonic	carbonic	ADJ
ecletica-285	47	11	anhydrase	anhydrase	NOUN
ecletica-285	47	12	,	,	PUNCT
ecletica-285	47	13	another	another	DET
ecletica-285	47	14	zinc	zinc	NOUN
ecletica-285	47	15	-	-	PUNCT
ecletica-285	47	16	enzyme	enzyme	NOUN
ecletica-285	47	17	,	,	PUNCT
ecletica-285	47	18	where	where	SCONJ
ecletica-285	47	19	the	the	DET
ecletica-285	47	20	hydroxylic	hydroxylic	ADJ
ecletica-285	47	21	oxygen	oxygen	NOUN
ecletica-285	47	22	bound	bind	VERB
ecletica-285	47	23	to	to	ADP
ecletica-285	47	24	zn2	zn2	PRON
ecletica-285	47	25	+	+	CCONJ
ecletica-285	47	26	attacks	attack	VERB
ecletica-285	47	27	the	the	DET
ecletica-285	47	28	carbon	carbon	NOUN
ecletica-285	47	29	of	of	ADP
ecletica-285	47	30	the	the	DET
ecletica-285	47	31	co2	co2	NOUN
ecletica-285	47	32	and	and	CCONJ
ecletica-285	47	33	produces	produce	VERB
ecletica-285	47	34	bicarbonate	bicarbonate	VERB
ecletica-285	47	35	,	,	PUNCT
ecletica-285	47	36	after	after	ADP
ecletica-285	47	37	rearrangement	rearrangement	NOUN
ecletica-285	47	38	and	and	CCONJ
ecletica-285	47	39	decomposition	decomposition	NOUN
ecletica-285	47	40	of	of	ADP
ecletica-285	47	41	the	the	DET
ecletica-285	47	42	intermediary	intermediary	ADJ
ecletica-285	47	43	species	specie	NOUN
ecletica-285	47	44	.	.	PUNCT
ecletica-285	48	1	on	on	ADP
ecletica-285	48	2	the	the	DET
ecletica-285	48	3	other	other	ADJ
ecletica-285	48	4	hand	hand	NOUN
ecletica-285	48	5	,	,	PUNCT
ecletica-285	48	6	the	the	DET
ecletica-285	48	7	mechanism	mechanism	NOUN
ecletica-285	48	8	of	of	ADP
ecletica-285	48	9	catalysis	catalysis	NOUN
ecletica-285	48	10	by	by	ADP
ecletica-285	48	11	matrix	matrix	NOUN
ecletica-285	48	12	metalloproteases	metalloprotease	NOUN
ecletica-285	48	13	,	,	PUNCT
ecletica-285	48	14	as	as	ADP
ecletica-285	48	15	the	the	DET
ecletica-285	48	16	human	human	ADJ
ecletica-285	48	17	collagenase	collagenase	NOUN
ecletica-285	48	18	,	,	PUNCT
ecletica-285	48	19	is	be	AUX
ecletica-285	48	20	an	an	DET
ecletica-285	48	21	example	example	NOUN
ecletica-285	48	22	of	of	ADP
ecletica-285	48	23	the	the	DET
ecletica-285	48	24	second	second	ADJ
ecletica-285	48	25	type	type	NOUN
ecletica-285	48	26	of	of	ADP
ecletica-285	48	27	mechanism	mechanism	NOUN
ecletica-285	48	28	.	.	PUNCT
ecletica-285	49	1	in	in	ADP
ecletica-285	49	2	this	this	DET
ecletica-285	49	3	case	case	NOUN
ecletica-285	49	4	,	,	PUNCT
ecletica-285	49	5	the	the	DET
ecletica-285	49	6	hydrolysis	hydrolysis	NOUN
ecletica-285	49	7	of	of	ADP
ecletica-285	49	8	the	the	DET
ecletica-285	49	9	amide	amide	NOUN
ecletica-285	49	10	(	(	PUNCT
ecletica-285	49	11	peptidic	peptidic	ADJ
ecletica-285	49	12	bond	bond	NOUN
ecletica-285	49	13	)	)	PUNCT
ecletica-285	49	14	begins	begin	VERB
ecletica-285	49	15	by	by	ADP
ecletica-285	49	16	attack	attack	NOUN
ecletica-285	49	17	of	of	ADP
ecletica-285	49	18	the	the	DET
ecletica-285	49	19	zinc	zinc	NOUN
ecletica-285	49	20	,	,	PUNCT
ecletica-285	49	21	as	as	ADP
ecletica-285	49	22	a	a	DET
ecletica-285	49	23	lewis	lewis	PROPN
ecletica-285	49	24	acid	acid	NOUN
ecletica-285	49	25	,	,	PUNCT
ecletica-285	49	26	on	on	ADP
ecletica-285	49	27	the	the	DET
ecletica-285	49	28	carbonylic	carbonylic	ADJ
ecletica-285	49	29	oxygen	oxygen	NOUN
ecletica-285	49	30	,	,	PUNCT
ecletica-285	49	31	polarizing	polarize	VERB
ecletica-285	49	32	the	the	DET
ecletica-285	49	33	carbonyl	carbonyl	NOUN
ecletica-285	49	34	and	and	CCONJ
ecletica-285	49	35	facilitating	facilitate	VERB
ecletica-285	49	36	the	the	DET
ecletica-285	49	37	attack	attack	NOUN
ecletica-285	49	38	of	of	ADP
ecletica-285	49	39	its	its	PRON
ecletica-285	49	40	carbon	carbon	NOUN
ecletica-285	49	41	by	by	ADP
ecletica-285	49	42	the	the	DET
ecletica-285	49	43	hydroxyl	hydroxyl	NOUN
ecletica-285	49	44	of	of	ADP
ecletica-285	49	45	water	water	NOUN
ecletica-285	49	46	linked	link	VERB
ecletica-285	49	47	to	to	ADP
ecletica-285	49	48	zinc	zinc	NOUN
ecletica-285	49	49	.	.	PUNCT
ecletica-285	50	1	the	the	DET
ecletica-285	50	2	intermediary	intermediary	NOUN
ecletica-285	50	3	,	,	PUNCT
ecletica-285	50	4	negatively	negatively	ADV
ecletica-285	50	5	charged	charge	VERB
ecletica-285	50	6	,	,	PUNCT
ecletica-285	50	7	then	then	ADV
ecletica-285	50	8	decomposes	decompose	VERB
ecletica-285	50	9	into	into	ADP
ecletica-285	50	10	carboxylate	carboxylate	NOUN
ecletica-285	50	11	and	and	CCONJ
ecletica-285	50	12	amine	amine	NOUN
ecletica-285	50	13	.	.	PUNCT
ecletica-285	51	1	the	the	DET
ecletica-285	51	2	synthetic	synthetic	ADJ
ecletica-285	51	3	inhibitors	inhibitor	NOUN
ecletica-285	51	4	of	of	ADP
ecletica-285	51	5	the	the	DET
ecletica-285	51	6	mmps	mmp	NOUN
ecletica-285	51	7	obtained	obtain	VERB
ecletica-285	51	8	until	until	ADP
ecletica-285	51	9	now	now	ADV
ecletica-285	51	10	are	be	AUX
ecletica-285	51	11	substances	substance	NOUN
ecletica-285	51	12	that	that	PRON
ecletica-285	51	13	bind	bind	VERB
ecletica-285	51	14	directly	directly	ADV
ecletica-285	51	15	or	or	CCONJ
ecletica-285	51	16	indirectly	indirectly	ADV
ecletica-285	51	17	to	to	ADP
ecletica-285	51	18	the	the	DET
ecletica-285	51	19	catalytic	catalytic	ADJ
ecletica-285	51	20	zinc	zinc	NOUN
ecletica-285	51	21	ion	ion	NOUN
ecletica-285	51	22	.	.	PUNCT
ecletica-285	52	1	they	they	PRON
ecletica-285	52	2	are	be	AUX
ecletica-285	52	3	species	specie	NOUN
ecletica-285	52	4	containing	contain	VERB
ecletica-285	52	5	the	the	DET
ecletica-285	52	6	groups	group	NOUN
ecletica-285	52	7	hydroxamate	hydroxamate	VERB
ecletica-285	52	8	,	,	PUNCT
ecletica-285	52	9	carboxylate	carboxylate	NOUN
ecletica-285	52	10	,	,	PUNCT
ecletica-285	52	11	sulfydryl	sulfydryl	NOUN
ecletica-285	52	12	,	,	PUNCT
ecletica-285	52	13	sulfoximine	sulfoximine	NOUN
ecletica-285	52	14	,	,	PUNCT
ecletica-285	52	15	sulfodiimine	sulfodiimine	NOUN
ecletica-285	52	16	,	,	PUNCT
ecletica-285	52	17	sulfonamide	sulfonamide	NOUN
ecletica-285	52	18	or	or	CCONJ
ecletica-285	52	19	thiol	thiol	NOUN
ecletica-285	52	20	[	[	X
ecletica-285	52	21	2	2	NUM
ecletica-285	52	22	,	,	PUNCT
ecletica-285	52	23	3	3	NUM
ecletica-285	52	24	,	,	PUNCT
ecletica-285	52	25	19	19	NUM
ecletica-285	52	26	-	-	SYM
ecletica-285	52	27	21	21	NUM
ecletica-285	52	28	]	]	PUNCT
ecletica-285	52	29	.	.	PUNCT
ecletica-285	53	1	the	the	DET
ecletica-285	53	2	study	study	NOUN
ecletica-285	53	3	of	of	ADP
ecletica-285	53	4	the	the	DET
ecletica-285	53	5	interaction	interaction	NOUN
ecletica-285	53	6	of	of	ADP
ecletica-285	53	7	inhibitors	inhibitor	NOUN
ecletica-285	53	8	with	with	ADP
ecletica-285	53	9	the	the	DET
ecletica-285	53	10	mmps	mmp	NOUN
ecletica-285	53	11	,	,	PUNCT
ecletica-285	53	12	mainly	mainly	ADV
ecletica-285	53	13	the	the	DET
ecletica-285	53	14	structure	structure	NOUN
ecletica-285	53	15	determination	determination	NOUN
ecletica-285	53	16	of	of	ADP
ecletica-285	53	17	enzyme	enzyme	NOUN
ecletica-285	53	18	-	-	PUNCT
ecletica-285	53	19	inhibitor	inhibitor	NOUN
ecletica-285	53	20	ecl	ecl	PROPN
ecletica-285	53	21	.	.	PROPN
ecletica-285	53	22	quím	quím	PROPN
ecletica-285	53	23	.	.	PUNCT
ecletica-285	53	24	,	,	PUNCT
ecletica-285	53	25	são	são	PROPN
ecletica-285	53	26	paulo	paulo	PROPN
ecletica-285	53	27	,	,	PUNCT
ecletica-285	53	28	34(4	34(4	NUM
ecletica-285	53	29	):	):	PUNCT
ecletica-285	53	30	87	87	NUM
ecletica-285	53	31	102	102	NUM
ecletica-285	53	32	,	,	PUNCT
ecletica-285	53	33	2009	2009	NUM
ecletica-285	53	34	89	89	NUM
ecletica-285	53	35	artigo	artigo	NOUN
ecletica-285	53	36	article	article	NOUN
ecletica-285	53	37	complexes	complex	NOUN
ecletica-285	53	38	,	,	PUNCT
ecletica-285	53	39	is	be	AUX
ecletica-285	53	40	essential	essential	ADJ
ecletica-285	53	41	to	to	PART
ecletica-285	53	42	understand	understand	VERB
ecletica-285	53	43	the	the	DET
ecletica-285	53	44	structural	structural	ADJ
ecletica-285	53	45	features	feature	NOUN
ecletica-285	53	46	relevant	relevant	ADJ
ecletica-285	53	47	for	for	ADP
ecletica-285	53	48	the	the	DET
ecletica-285	53	49	inhibition	inhibition	NOUN
ecletica-285	53	50	.	.	PUNCT
ecletica-285	54	1	these	these	DET
ecletica-285	54	2	informations	information	NOUN
ecletica-285	54	3	constitute	constitute	VERB
ecletica-285	54	4	the	the	DET
ecletica-285	54	5	basis	basis	NOUN
ecletica-285	54	6	for	for	ADP
ecletica-285	54	7	the	the	DET
ecletica-285	54	8	rational	rational	ADJ
ecletica-285	54	9	search	search	NOUN
ecletica-285	54	10	of	of	ADP
ecletica-285	54	11	new	new	ADJ
ecletica-285	54	12	more	more	ADV
ecletica-285	54	13	potent	potent	ADJ
ecletica-285	54	14	inhibitors	inhibitor	NOUN
ecletica-285	54	15	,	,	PUNCT
ecletica-285	54	16	through	through	ADP
ecletica-285	54	17	theoretical	theoretical	ADJ
ecletica-285	54	18	chemistry	chemistry	NOUN
ecletica-285	54	19	calculations	calculation	NOUN
ecletica-285	54	20	,	,	PUNCT
ecletica-285	54	21	whose	whose	DET
ecletica-285	54	22	results	result	NOUN
ecletica-285	54	23	guide	guide	VERB
ecletica-285	54	24	their	their	PRON
ecletica-285	54	25	synthesis	synthesis	NOUN
ecletica-285	54	26	.	.	PUNCT
ecletica-285	55	1	in	in	ADP
ecletica-285	55	2	the	the	DET
ecletica-285	55	3	present	present	ADJ
ecletica-285	55	4	work	work	NOUN
ecletica-285	55	5	some	some	DET
ecletica-285	55	6	common	common	ADJ
ecletica-285	55	7	drugs	drug	NOUN
ecletica-285	55	8	were	be	AUX
ecletica-285	55	9	tested	test	VERB
ecletica-285	55	10	as	as	ADP
ecletica-285	55	11	inhibitors	inhibitor	NOUN
ecletica-285	55	12	of	of	ADP
ecletica-285	55	13	the	the	DET
ecletica-285	55	14	human	human	ADJ
ecletica-285	55	15	collagenase	collagenase	NOUN
ecletica-285	55	16	mmp-1	mmp-1	ADP
ecletica-285	55	17	,	,	PUNCT
ecletica-285	55	18	both	both	CCONJ
ecletica-285	55	19	experimental	experimental	ADJ
ecletica-285	55	20	and	and	CCONJ
ecletica-285	55	21	theoretically	theoretically	ADV
ecletica-285	55	22	.	.	PUNCT
ecletica-285	56	1	the	the	DET
ecletica-285	56	2	choice	choice	NOUN
ecletica-285	56	3	of	of	ADP
ecletica-285	56	4	such	such	ADJ
ecletica-285	56	5	drugs	drug	NOUN
ecletica-285	56	6	,	,	PUNCT
ecletica-285	56	7	currently	currently	ADV
ecletica-285	56	8	employed	employ	VERB
ecletica-285	56	9	for	for	ADP
ecletica-285	56	10	other	other	ADJ
ecletica-285	56	11	pathologies	pathology	NOUN
ecletica-285	56	12	,	,	PUNCT
ecletica-285	56	13	was	be	AUX
ecletica-285	56	14	made	make	VERB
ecletica-285	56	15	based	base	VERB
ecletica-285	56	16	on	on	ADP
ecletica-285	56	17	experimental	experimental	ADJ
ecletica-285	56	18	and	and	CCONJ
ecletica-285	56	19	clinical	clinical	ADJ
ecletica-285	56	20	references	reference	NOUN
ecletica-285	56	21	[	[	X
ecletica-285	56	22	22	22	NUM
ecletica-285	56	23	]	]	PUNCT
ecletica-285	56	24	.	.	PUNCT
ecletica-285	57	1	the	the	DET
ecletica-285	57	2	great	great	ADJ
ecletica-285	57	3	advantage	advantage	NOUN
ecletica-285	57	4	in	in	ADP
ecletica-285	57	5	selecting	select	VERB
ecletica-285	57	6	drugs	drug	NOUN
ecletica-285	57	7	already	already	ADV
ecletica-285	57	8	used	use	VERB
ecletica-285	57	9	in	in	ADP
ecletica-285	57	10	other	other	ADJ
ecletica-285	57	11	pathologies	pathology	NOUN
ecletica-285	57	12	is	be	AUX
ecletica-285	57	13	the	the	DET
ecletica-285	57	14	previous	previous	ADJ
ecletica-285	57	15	knowledge	knowledge	NOUN
ecletica-285	57	16	of	of	ADP
ecletica-285	57	17	their	their	PRON
ecletica-285	57	18	toxicity	toxicity	NOUN
ecletica-285	57	19	and	and	CCONJ
ecletica-285	57	20	safety	safety	NOUN
ecletica-285	57	21	,	,	PUNCT
ecletica-285	57	22	checked	check	VERB
ecletica-285	57	23	by	by	ADP
ecletica-285	57	24	the	the	DET
ecletica-285	57	25	acquired	acquire	VERB
ecletica-285	57	26	clinical	clinical	ADJ
ecletica-285	57	27	experience	experience	NOUN
ecletica-285	57	28	.	.	PUNCT
ecletica-285	58	1	experimental	experimental	ADJ
ecletica-285	58	2	methods	method	NOUN
ecletica-285	58	3	human	human	PROPN
ecletica-285	58	4	collagenase	collagenase	NOUN
ecletica-285	58	5	(	(	PUNCT
ecletica-285	58	6	mmp-1	mmp-1	NOUN
ecletica-285	58	7	)	)	PUNCT
ecletica-285	58	8	was	be	AUX
ecletica-285	58	9	purchased	purchase	VERB
ecletica-285	58	10	from	from	ADP
ecletica-285	58	11	icn	icn	PROPN
ecletica-285	58	12	biomedicals	biomedicals	PROPN
ecletica-285	58	13	inc	inc	PROPN
ecletica-285	58	14	.	.	PROPN
ecletica-285	58	15	,	,	PUNCT
ecletica-285	58	16	livermore	livermore	PROPN
ecletica-285	58	17	,	,	PUNCT
ecletica-285	58	18	ca	ca	PROPN
ecletica-285	58	19	,	,	PUNCT
ecletica-285	58	20	usa	usa	PROPN
ecletica-285	58	21	.	.	PUNCT
ecletica-285	59	1	the	the	DET
ecletica-285	59	2	activity	activity	NOUN
ecletica-285	59	3	of	of	ADP
ecletica-285	59	4	this	this	DET
ecletica-285	59	5	enzyme	enzyme	NOUN
ecletica-285	59	6	was	be	AUX
ecletica-285	59	7	measured	measure	VERB
ecletica-285	59	8	by	by	ADP
ecletica-285	59	9	reaction	reaction	NOUN
ecletica-285	59	10	with	with	ADP
ecletica-285	59	11	the	the	DET
ecletica-285	59	12	synthetic	synthetic	ADJ
ecletica-285	59	13	substrate	substrate	NOUN
ecletica-285	59	14	7	7	NUM
ecletica-285	59	15	-	-	PUNCT
ecletica-285	59	16	methoxycoumarin-4	methoxycoumarin-4	NOUN
ecletica-285	59	17	-	-	PUNCT
ecletica-285	59	18	acetyl	acetyl	NOUN
ecletica-285	59	19	-	-	PUNCT
ecletica-285	59	20	pro	pro	ADJ
ecletica-285	59	21	-	-	ADJ
ecletica-285	59	22	leu	leu	ADJ
ecletica-285	59	23	-	-	PUNCT
ecletica-285	59	24	gly	gly	ADV
ecletica-285	59	25	-	-	PUNCT
ecletica-285	59	26	leuβ-(2,4	leuβ-(2,4	ADJ
ecletica-285	59	27	-	-	PUNCT
ecletica-285	59	28	dinitrophenyl	dinitrophenyl	NOUN
ecletica-285	59	29	)	)	PUNCT
ecletica-285	59	30	l-2	l-2	PROPN
ecletica-285	59	31	,	,	PUNCT
ecletica-285	59	32	3	3	NUM
ecletica-285	59	33	-	-	PUNCT
ecletica-285	59	34	diaminopropionyl)ala	diaminopropionyl)ala	NOUN
ecletica-285	59	35	-	-	PUNCT
ecletica-285	59	36	arg	arg	NOUN
ecletica-285	59	37	-	-	PUNCT
ecletica-285	59	38	nh2	nh2	NOUN
ecletica-285	59	39	(	(	PUNCT
ecletica-285	59	40	abbreviated	abbreviate	VERB
ecletica-285	59	41	mca	mca	PROPN
ecletica-285	59	42	-	-	PUNCT
ecletica-285	59	43	pro	pro	ADJ
ecletica-285	59	44	-	-	ADJ
ecletica-285	59	45	leugly	leugly	ADJ
ecletica-285	59	46	-	-	PUNCT
ecletica-285	59	47	leu	leu	NOUN
ecletica-285	59	48	-	-	PUNCT
ecletica-285	59	49	dpa	dpa	PROPN
ecletica-285	59	50	-	-	PUNCT
ecletica-285	59	51	ala	ala	NOUN
ecletica-285	59	52	-	-	PUNCT
ecletica-285	59	53	arg	arg	NOUN
ecletica-285	59	54	-	-	PUNCT
ecletica-285	59	55	nh2	nh2	NOUN
ecletica-285	59	56	,	,	PUNCT
ecletica-285	59	57	from	from	ADP
ecletica-285	59	58	sigma	sigma	PROPN
ecletica-285	59	59	-	-	PUNCT
ecletica-285	59	60	aldrich	aldrich	PROPN
ecletica-285	59	61	co.	co.	PROPN
ecletica-285	59	62	,	,	PUNCT
ecletica-285	59	63	saint	saint	PROPN
ecletica-285	59	64	louis	louis	PROPN
ecletica-285	59	65	,	,	PUNCT
ecletica-285	59	66	mo	mo	PROPN
ecletica-285	59	67	,	,	PUNCT
ecletica-285	59	68	usa	usa	PROPN
ecletica-285	59	69	)	)	PUNCT
ecletica-285	59	70	.	.	PUNCT
ecletica-285	60	1	in	in	ADP
ecletica-285	60	2	this	this	DET
ecletica-285	60	3	compound	compound	NOUN
ecletica-285	60	4	,	,	PUNCT
ecletica-285	60	5	the	the	DET
ecletica-285	60	6	fluorescent	fluorescent	ADJ
ecletica-285	60	7	emission	emission	NOUN
ecletica-285	60	8	of	of	ADP
ecletica-285	60	9	methoxycoumarin	methoxycoumarin	NOUN
ecletica-285	60	10	group	group	NOUN
ecletica-285	60	11	is	be	AUX
ecletica-285	60	12	quenched	quench	VERB
ecletica-285	60	13	by	by	ADP
ecletica-285	60	14	2,4dinitrophenyl	2,4dinitrophenyl	NUM
ecletica-285	60	15	-	-	ADJ
ecletica-285	60	16	amino	amino	ADJ
ecletica-285	60	17	ring	ring	NOUN
ecletica-285	60	18	.	.	PUNCT
ecletica-285	61	1	the	the	DET
ecletica-285	61	2	hydrolysis	hydrolysis	NOUN
ecletica-285	61	3	of	of	ADP
ecletica-285	61	4	the	the	DET
ecletica-285	61	5	peptide	peptide	NOUN
ecletica-285	61	6	chain	chain	NOUN
ecletica-285	61	7	by	by	ADP
ecletica-285	61	8	mmp-1	mmp-1	PUNCT
ecletica-285	61	9	between	between	ADP
ecletica-285	61	10	the	the	DET
ecletica-285	61	11	gly	gly	NOUN
ecletica-285	61	12	and	and	CCONJ
ecletica-285	61	13	leu	leu	PROPN
ecletica-285	61	14	residues	residue	NOUN
ecletica-285	61	15	extinguishes	extinguish	VERB
ecletica-285	61	16	this	this	DET
ecletica-285	61	17	effect	effect	NOUN
ecletica-285	61	18	and	and	CCONJ
ecletica-285	61	19	enhances	enhance	VERB
ecletica-285	61	20	the	the	DET
ecletica-285	61	21	fluorescence	fluorescence	NOUN
ecletica-285	61	22	at	at	ADP
ecletica-285	61	23	394	394	NUM
ecletica-285	61	24	nm	nm	NOUN
ecletica-285	61	25	,	,	PUNCT
ecletica-285	61	26	proportionally	proportionally	ADV
ecletica-285	61	27	to	to	ADP
ecletica-285	61	28	collagenase	collagenase	NOUN
ecletica-285	61	29	activity	activity	NOUN
ecletica-285	61	30	[	[	X
ecletica-285	61	31	23	23	NUM
ecletica-285	61	32	]	]	PUNCT
ecletica-285	61	33	.	.	PUNCT
ecletica-285	62	1	the	the	DET
ecletica-285	62	2	reactions	reaction	NOUN
ecletica-285	62	3	were	be	AUX
ecletica-285	62	4	performed	perform	VERB
ecletica-285	62	5	in	in	ADP
ecletica-285	62	6	a	a	DET
ecletica-285	62	7	buffered	buffer	VERB
ecletica-285	62	8	medium	medium	NOUN
ecletica-285	62	9	(	(	PUNCT
ecletica-285	62	10	tricine	tricine	NOUN
ecletica-285	62	11	50	50	NUM
ecletica-285	62	12	mm	mm	NOUN
ecletica-285	62	13	ph	ph	PROPN
ecletica-285	62	14	7.5	7.5	NUM
ecletica-285	62	15	)	)	PUNCT
ecletica-285	62	16	containing	contain	VERB
ecletica-285	62	17	ca2	ca2	PROPN
ecletica-285	62	18	+	+	PROPN
ecletica-285	62	19	10	10	NUM
ecletica-285	62	20	mm	mm	NOUN
ecletica-285	62	21	and	and	CCONJ
ecletica-285	62	22	nacl	nacl	NOUN
ecletica-285	62	23	0,10	0,10	NUM
ecletica-285	62	24	m	m	VERB
ecletica-285	62	25	,	,	PUNCT
ecletica-285	62	26	in	in	ADP
ecletica-285	62	27	a	a	DET
ecletica-285	62	28	total	total	ADJ
ecletica-285	62	29	volume	volume	NOUN
ecletica-285	62	30	of	of	ADP
ecletica-285	62	31	100µl	100µl	PROPN
ecletica-285	62	32	.	.	PUNCT
ecletica-285	63	1	the	the	DET
ecletica-285	63	2	mmp-1	mmp-1	PRON
ecletica-285	63	3	concentration	concentration	NOUN
ecletica-285	63	4	was	be	AUX
ecletica-285	63	5	always	always	ADV
ecletica-285	63	6	10	10	NUM
ecletica-285	63	7	mm	mm	NOUN
ecletica-285	63	8	and	and	CCONJ
ecletica-285	63	9	that	that	PRON
ecletica-285	63	10	of	of	ADP
ecletica-285	63	11	fluorogenic	fluorogenic	ADJ
ecletica-285	63	12	reagent	reagent	NOUN
ecletica-285	63	13	varied	varied	ADJ
ecletica-285	63	14	from	from	ADP
ecletica-285	63	15	1	1	NUM
ecletica-285	63	16	to	to	PART
ecletica-285	63	17	10	10	NUM
ecletica-285	63	18	µm	µm	NOUN
ecletica-285	63	19	.	.	PUNCT
ecletica-285	64	1	the	the	DET
ecletica-285	64	2	fluorescence	fluorescence	NOUN
ecletica-285	64	3	was	be	AUX
ecletica-285	64	4	measured	measure	VERB
ecletica-285	64	5	in	in	ADP
ecletica-285	64	6	a	a	DET
ecletica-285	64	7	microfluorimeter	microfluorimeter	NOUN
ecletica-285	64	8	(	(	PUNCT
ecletica-285	64	9	tecan	tecan	PROPN
ecletica-285	64	10	austria	austria	PROPN
ecletica-285	64	11	gesellschaft	gesellschaft	PROPN
ecletica-285	64	12	,	,	PUNCT
ecletica-285	64	13	salzburg	salzburg	PROPN
ecletica-285	64	14	,	,	PUNCT
ecletica-285	64	15	austria	austria	PROPN
ecletica-285	64	16	)	)	PUNCT
ecletica-285	64	17	,	,	PUNCT
ecletica-285	64	18	with	with	ADP
ecletica-285	64	19	excitation	excitation	NOUN
ecletica-285	64	20	wavelength	wavelength	NOUN
ecletica-285	64	21	at	at	ADP
ecletica-285	64	22	330	330	NUM
ecletica-285	64	23	nm	nm	NOUN
ecletica-285	64	24	and	and	CCONJ
ecletica-285	64	25	emission	emission	NOUN
ecletica-285	64	26	at	at	ADP
ecletica-285	64	27	394	394	NUM
ecletica-285	64	28	nm	nm	NOUN
ecletica-285	64	29	.	.	PUNCT
ecletica-285	65	1	the	the	DET
ecletica-285	65	2	choice	choice	NOUN
ecletica-285	65	3	of	of	ADP
ecletica-285	65	4	substances	substance	NOUN
ecletica-285	65	5	for	for	ADP
ecletica-285	65	6	the	the	DET
ecletica-285	65	7	inhibition	inhibition	NOUN
ecletica-285	65	8	tests	test	NOUN
ecletica-285	65	9	was	be	AUX
ecletica-285	65	10	based	base	VERB
ecletica-285	65	11	on	on	ADP
ecletica-285	65	12	reports	report	NOUN
ecletica-285	65	13	in	in	ADP
ecletica-285	65	14	the	the	DET
ecletica-285	65	15	literature	literature	NOUN
ecletica-285	65	16	(	(	PUNCT
ecletica-285	65	17	experimental	experimental	ADJ
ecletica-285	65	18	or	or	CCONJ
ecletica-285	65	19	clinical	clinical	ADJ
ecletica-285	65	20	)	)	PUNCT
ecletica-285	65	21	among	among	ADP
ecletica-285	65	22	common	common	ADJ
ecletica-285	65	23	drugs	drug	NOUN
ecletica-285	65	24	with	with	ADP
ecletica-285	65	25	inhibiting	inhibit	VERB
ecletica-285	65	26	effect	effect	NOUN
ecletica-285	65	27	upon	upon	SCONJ
ecletica-285	65	28	collagenases	collagenase	NOUN
ecletica-285	65	29	.	.	PUNCT
ecletica-285	66	1	the	the	DET
ecletica-285	66	2	selected	select	VERB
ecletica-285	66	3	drugs	drug	NOUN
ecletica-285	66	4	have	have	VERB
ecletica-285	66	5	different	different	ADJ
ecletica-285	66	6	structures	structure	NOUN
ecletica-285	66	7	and	and	CCONJ
ecletica-285	66	8	pharmacological	pharmacological	ADJ
ecletica-285	66	9	activities	activity	NOUN
ecletica-285	66	10	,	,	PUNCT
ecletica-285	66	11	but	but	CCONJ
ecletica-285	66	12	all	all	PRON
ecletica-285	66	13	share	share	VERB
ecletica-285	66	14	such	such	ADJ
ecletica-285	66	15	supposed	suppose	VERB
ecletica-285	66	16	inhibiting	inhibit	VERB
ecletica-285	66	17	effect	effect	NOUN
ecletica-285	66	18	[	[	X
ecletica-285	66	19	22	22	NUM
ecletica-285	66	20	]	]	PUNCT
ecletica-285	66	21	.	.	PUNCT
ecletica-285	67	1	four	four	NUM
ecletica-285	67	2	ligands	ligand	NOUN
ecletica-285	67	3	were	be	AUX
ecletica-285	67	4	tested	test	VERB
ecletica-285	67	5	:	:	PUNCT
ecletica-285	67	6	three	three	NUM
ecletica-285	67	7	oxicans	oxican	NOUN
ecletica-285	67	8	,	,	PUNCT
ecletica-285	67	9	namely	namely	ADV
ecletica-285	67	10	meloxicam	meloxicam	NOUN
ecletica-285	67	11	,	,	PUNCT
ecletica-285	67	12	tenoxicam	tenoxicam	NOUN
ecletica-285	67	13	and	and	CCONJ
ecletica-285	67	14	piroxicam	piroxicam	VERB
ecletica-285	67	15	,	,	PUNCT
ecletica-285	67	16	and	and	CCONJ
ecletica-285	67	17	sodium	sodium	NOUN
ecletica-285	67	18	alendronate	alendronate	NOUN
ecletica-285	67	19	.	.	PUNCT
ecletica-285	68	1	the	the	DET
ecletica-285	68	2	ic50	ic50	PROPN
ecletica-285	68	3	was	be	AUX
ecletica-285	68	4	determined	determine	VERB
ecletica-285	68	5	for	for	ADP
ecletica-285	68	6	those	those	PRON
ecletica-285	68	7	that	that	PRON
ecletica-285	68	8	exhibited	exhibit	VERB
ecletica-285	68	9	activity	activity	NOUN
ecletica-285	68	10	against	against	ADP
ecletica-285	68	11	the	the	DET
ecletica-285	68	12	enzyme	enzyme	NOUN
ecletica-285	68	13	.	.	PUNCT
ecletica-285	69	1	computational	computational	ADJ
ecletica-285	69	2	methods	method	NOUN
ecletica-285	69	3	computational	computational	ADJ
ecletica-285	69	4	calculations	calculation	NOUN
ecletica-285	69	5	performed	perform	VERB
ecletica-285	69	6	were	be	AUX
ecletica-285	69	7	:	:	PUNCT
ecletica-285	69	8	modeling	modeling	NOUN
ecletica-285	69	9	of	of	ADP
ecletica-285	69	10	the	the	DET
ecletica-285	69	11	three	three	NUM
ecletica-285	69	12	-	-	PUNCT
ecletica-285	69	13	dimensional	dimensional	ADJ
ecletica-285	69	14	structure	structure	NOUN
ecletica-285	69	15	of	of	ADP
ecletica-285	69	16	the	the	DET
ecletica-285	69	17	ligands	ligand	NOUN
ecletica-285	69	18	by	by	ADP
ecletica-285	69	19	energy	energy	NOUN
ecletica-285	69	20	minimization	minimization	NOUN
ecletica-285	69	21	methods	method	NOUN
ecletica-285	69	22	,	,	PUNCT
ecletica-285	69	23	calculation	calculation	NOUN
ecletica-285	69	24	of	of	ADP
ecletica-285	69	25	electronic	electronic	ADJ
ecletica-285	69	26	and	and	CCONJ
ecletica-285	69	27	thermodynamics	thermodynamic	NOUN
ecletica-285	69	28	properties	property	NOUN
ecletica-285	69	29	and	and	CCONJ
ecletica-285	69	30	simulation	simulation	NOUN
ecletica-285	69	31	of	of	ADP
ecletica-285	69	32	the	the	DET
ecletica-285	69	33	interaction	interaction	NOUN
ecletica-285	69	34	between	between	ADP
ecletica-285	69	35	ligands	ligand	NOUN
ecletica-285	69	36	and	and	CCONJ
ecletica-285	69	37	collagenase	collagenase	ADJ
ecletica-285	69	38	active	active	ADJ
ecletica-285	69	39	site	site	NOUN
ecletica-285	69	40	by	by	ADP
ecletica-285	69	41	a	a	DET
ecletica-285	69	42	docking	docking	NOUN
ecletica-285	69	43	procedure	procedure	NOUN
ecletica-285	69	44	.	.	PUNCT
ecletica-285	70	1	the	the	DET
ecletica-285	70	2	enzyme	enzyme	NOUN
ecletica-285	70	3	structure	structure	NOUN
ecletica-285	70	4	was	be	AUX
ecletica-285	70	5	obtained	obtain	VERB
ecletica-285	70	6	from	from	ADP
ecletica-285	70	7	protein	protein	NOUN
ecletica-285	70	8	data	datum	NOUN
ecletica-285	70	9	bank	bank	NOUN
ecletica-285	70	10	(	(	PUNCT
ecletica-285	70	11	structure	structure	NOUN
ecletica-285	70	12	1cgl	1cgl	NUM
ecletica-285	70	13	)	)	PUNCT
ecletica-285	70	14	,	,	PUNCT
ecletica-285	70	15	determined	determine	VERB
ecletica-285	70	16	by	by	ADP
ecletica-285	70	17	x	x	NOUN
ecletica-285	70	18	-	-	NOUN
ecletica-285	70	19	ray	ray	NOUN
ecletica-285	70	20	diffraction	diffraction	NOUN
ecletica-285	71	1	[	[	X
ecletica-285	71	2	24	24	NUM
ecletica-285	71	3	,	,	PUNCT
ecletica-285	71	4	25	25	NUM
ecletica-285	71	5	]	]	PUNCT
ecletica-285	71	6	.	.	PUNCT
ecletica-285	72	1	this	this	DET
ecletica-285	72	2	structure	structure	NOUN
ecletica-285	72	3	refers	refer	VERB
ecletica-285	72	4	to	to	ADP
ecletica-285	72	5	collagenase	collagenase	NOUN
ecletica-285	72	6	co	co	VERB
ecletica-285	72	7	-	-	VERB
ecletica-285	72	8	crystallized	crystallize	VERB
ecletica-285	72	9	with	with	ADP
ecletica-285	72	10	an	an	DET
ecletica-285	72	11	inhibitor	inhibitor	NOUN
ecletica-285	72	12	and	and	CCONJ
ecletica-285	72	13	informs	inform	VERB
ecletica-285	72	14	about	about	ADP
ecletica-285	72	15	the	the	DET
ecletica-285	72	16	molecule	molecule	NOUN
ecletica-285	72	17	region	region	NOUN
ecletica-285	72	18	interacting	interact	VERB
ecletica-285	72	19	with	with	ADP
ecletica-285	72	20	the	the	DET
ecletica-285	72	21	ligands	ligand	NOUN
ecletica-285	72	22	.	.	PUNCT
ecletica-285	73	1	calculations	calculation	NOUN
ecletica-285	73	2	were	be	AUX
ecletica-285	73	3	performed	perform	VERB
ecletica-285	73	4	on	on	ADP
ecletica-285	73	5	a	a	DET
ecletica-285	73	6	compaq	compaq	NOUN
ecletica-285	73	7	ap400	ap400	INTJ
ecletica-285	73	8	workstation	workstation	NOUN
ecletica-285	73	9	with	with	ADP
ecletica-285	73	10	two	two	NUM
ecletica-285	73	11	processors	processor	NOUN
ecletica-285	73	12	(	(	PUNCT
ecletica-285	73	13	windows	window	NOUN
ecletica-285	73	14	software	software	NOUN
ecletica-285	73	15	for	for	ADP
ecletica-285	73	16	classical	classical	ADJ
ecletica-285	73	17	and	and	CCONJ
ecletica-285	73	18	quantum	quantum	ADJ
ecletica-285	73	19	mechanical	mechanical	ADJ
ecletica-285	73	20	energy	energy	NOUN
ecletica-285	73	21	minimization	minimization	NOUN
ecletica-285	73	22	and	and	CCONJ
ecletica-285	73	23	molecular	molecular	ADJ
ecletica-285	73	24	dynamics	dynamic	NOUN
ecletica-285	73	25	)	)	PUNCT
ecletica-285	73	26	and	and	CCONJ
ecletica-285	73	27	on	on	ADP
ecletica-285	73	28	a	a	DET
ecletica-285	73	29	silicon	silicon	NOUN
ecletica-285	73	30	graphics	graphic	NOUN
ecletica-285	73	31	octane	octane	NOUN
ecletica-285	73	32	workstation	workstation	NOUN
ecletica-285	73	33	(	(	PUNCT
ecletica-285	73	34	unix	unix	NOUN
ecletica-285	73	35	software	software	NOUN
ecletica-285	73	36	for	for	ADP
ecletica-285	73	37	docking	docking	NOUN
ecletica-285	73	38	and	and	CCONJ
ecletica-285	73	39	ab	ab	PROPN
ecletica-285	73	40	initio	initio	NOUN
ecletica-285	73	41	quantum	quantum	PROPN
ecletica-285	73	42	mechanical	mechanical	ADJ
ecletica-285	73	43	calculation	calculation	NOUN
ecletica-285	73	44	)	)	PUNCT
ecletica-285	73	45	.	.	PUNCT
ecletica-285	74	1	for	for	ADP
ecletica-285	74	2	the	the	DET
ecletica-285	74	3	former	former	ADJ
ecletica-285	74	4	the	the	DET
ecletica-285	74	5	softwares	software	NOUN
ecletica-285	74	6	used	use	VERB
ecletica-285	74	7	were	be	AUX
ecletica-285	74	8	:	:	PUNCT
ecletica-285	74	9	cache	cache	PROPN
ecletica-285	74	10	worksystem	worksystem	NOUN
ecletica-285	74	11	5.04	5.04	NUM
ecletica-285	74	12	for	for	ADP
ecletica-285	74	13	windows	window	NOUN
ecletica-285	74	14	(	(	PUNCT
ecletica-285	74	15	fujitsu	fujitsu	PROPN
ecletica-285	74	16	systems	systems	PROPN
ecletica-285	74	17	business	business	NOUN
ecletica-285	74	18	of	of	ADP
ecletica-285	74	19	america	america	PROPN
ecletica-285	74	20	,	,	PUNCT
ecletica-285	74	21	inc	inc	PROPN
ecletica-285	74	22	.	.	PROPN
ecletica-285	74	23	,	,	PUNCT
ecletica-285	74	24	beaverton	beaverton	PROPN
ecletica-285	74	25	,	,	PUNCT
ecletica-285	74	26	or	or	CCONJ
ecletica-285	74	27	,	,	PUNCT
ecletica-285	74	28	usa	usa	PROPN
ecletica-285	74	29	)	)	PUNCT
ecletica-285	75	1	[	[	X
ecletica-285	75	2	26	26	NUM
ecletica-285	75	3	]	]	PUNCT
ecletica-285	75	4	and	and	CCONJ
ecletica-285	75	5	hyperchem	hyperchem	NOUN
ecletica-285	75	6	4.5	4.5	NUM
ecletica-285	75	7	for	for	ADP
ecletica-285	75	8	windows	window	NOUN
ecletica-285	75	9	(	(	PUNCT
ecletica-285	75	10	hypercube	hypercube	PROPN
ecletica-285	75	11	,	,	PUNCT
ecletica-285	75	12	inc	inc	PROPN
ecletica-285	75	13	.	.	PROPN
ecletica-285	75	14	,	,	PUNCT
ecletica-285	75	15	waterloo	waterloo	PROPN
ecletica-285	75	16	,	,	PUNCT
ecletica-285	75	17	on	on	ADP
ecletica-285	75	18	,	,	PUNCT
ecletica-285	75	19	canada	canada	PROPN
ecletica-285	75	20	)	)	PUNCT
ecletica-285	76	1	[	[	X
ecletica-285	76	2	27	27	NUM
ecletica-285	76	3	]	]	PUNCT
ecletica-285	76	4	,	,	PUNCT
ecletica-285	76	5	and	and	CCONJ
ecletica-285	76	6	for	for	ADP
ecletica-285	76	7	the	the	DET
ecletica-285	76	8	last	last	ADJ
ecletica-285	76	9	first	first	ADJ
ecletica-285	76	10	discovery	discovery	NOUN
ecletica-285	76	11	1.8	1.8	NUM
ecletica-285	76	12	(	(	PUNCT
ecletica-285	76	13	modules	module	NOUN
ecletica-285	76	14	:	:	PUNCT
ecletica-285	76	15	glide	glide	NOUN
ecletica-285	76	16	;	;	PUNCT
ecletica-285	76	17	liaison	liaison	NOUN
ecletica-285	76	18	;	;	PUNCT
ecletica-285	76	19	qsite	qsite	NOUN
ecletica-285	76	20	;	;	PUNCT
ecletica-285	76	21	impact	impact	NOUN
ecletica-285	76	22	)	)	PUNCT
ecletica-285	76	23	and	and	CCONJ
ecletica-285	76	24	jaguar	jaguar	PROPN
ecletica-285	76	25	4.1	4.1	NUM
ecletica-285	76	26	.	.	PUNCT
ecletica-285	77	1	for	for	ADP
ecletica-285	77	2	irix	irix	NOUN
ecletica-285	77	3	(	(	PUNCT
ecletica-285	77	4	in	in	ADP
ecletica-285	77	5	other	other	ADJ
ecletica-285	77	6	words	word	NOUN
ecletica-285	77	7	,	,	PUNCT
ecletica-285	77	8	sgi	sgi	NOUN
ecletica-285	77	9	unix	unix	NOUN
ecletica-285	77	10	)	)	PUNCT
ecletica-285	77	11	(	(	PUNCT
ecletica-285	77	12	schrödinger	schrödinger	PROPN
ecletica-285	77	13	inc	inc	PROPN
ecletica-285	77	14	.	.	PROPN
ecletica-285	77	15	,	,	PUNCT
ecletica-285	77	16	portland	portland	PROPN
ecletica-285	77	17	,	,	PUNCT
ecletica-285	77	18	or	or	CCONJ
ecletica-285	77	19	,	,	PUNCT
ecletica-285	77	20	usa	usa	PROPN
ecletica-285	77	21	)	)	PUNCT
ecletica-285	77	22	[	[	X
ecletica-285	77	23	28	28	NUM
ecletica-285	77	24	]	]	PUNCT
ecletica-285	77	25	.	.	PUNCT
ecletica-285	78	1	a	a	DET
ecletica-285	78	2	)	)	PUNCT
ecletica-285	78	3	structure	structure	NOUN
ecletica-285	78	4	of	of	ADP
ecletica-285	78	5	ligands	ligand	NOUN
ecletica-285	78	6	:	:	PUNCT
ecletica-285	78	7	three	three	NUM
ecletica-285	78	8	-	-	PUNCT
ecletica-285	78	9	dimensional	dimensional	ADJ
ecletica-285	78	10	structure	structure	NOUN
ecletica-285	78	11	of	of	ADP
ecletica-285	78	12	the	the	DET
ecletica-285	78	13	ligands	ligand	NOUN
ecletica-285	78	14	was	be	AUX
ecletica-285	78	15	determined	determine	VERB
ecletica-285	78	16	by	by	ADP
ecletica-285	78	17	energy	energy	NOUN
ecletica-285	78	18	minimization	minimization	NOUN
ecletica-285	78	19	and	and	CCONJ
ecletica-285	78	20	molecular	molecular	ADJ
ecletica-285	78	21	dynamics	dynamic	NOUN
ecletica-285	78	22	simulated	simulate	VERB
ecletica-285	78	23	annealing	annealing	NOUN
ecletica-285	78	24	,	,	PUNCT
ecletica-285	78	25	alternately	alternately	ADV
ecletica-285	78	26	,	,	PUNCT
ecletica-285	78	27	many	many	ADJ
ecletica-285	78	28	times	time	NOUN
ecletica-285	78	29	,	,	PUNCT
ecletica-285	78	30	to	to	PART
ecletica-285	78	31	obtain	obtain	VERB
ecletica-285	78	32	a	a	DET
ecletica-285	78	33	structure	structure	NOUN
ecletica-285	78	34	in	in	ADP
ecletica-285	78	35	a	a	DET
ecletica-285	78	36	lower	low	ADJ
ecletica-285	78	37	energy	energy	NOUN
ecletica-285	78	38	minimum	minimum	NOUN
ecletica-285	78	39	.	.	PUNCT
ecletica-285	79	1	the	the	DET
ecletica-285	79	2	calculation	calculation	NOUN
ecletica-285	79	3	was	be	AUX
ecletica-285	79	4	performed	perform	VERB
ecletica-285	79	5	by	by	ADP
ecletica-285	79	6	the	the	DET
ecletica-285	79	7	semiempirical	semiempirical	ADJ
ecletica-285	79	8	quantum	quantum	ADJ
ecletica-285	79	9	mechanical	mechanical	ADJ
ecletica-285	79	10	method	method	NOUN
ecletica-285	79	11	pm3	pm3	PROPN
ecletica-285	80	1	[	[	X
ecletica-285	80	2	29	29	NUM
ecletica-285	80	3	]	]	PUNCT
ecletica-285	80	4	.	.	PUNCT
ecletica-285	81	1	b	b	X
ecletica-285	81	2	)	)	PUNCT
ecletica-285	81	3	ligand	ligand	ADJ
ecletica-285	81	4	electronic	electronic	ADJ
ecletica-285	81	5	properties	property	NOUN
ecletica-285	81	6	:	:	PUNCT
ecletica-285	81	7	electronic	electronic	ADJ
ecletica-285	81	8	densities	density	NOUN
ecletica-285	81	9	and	and	CCONJ
ecletica-285	81	10	mülliken	mülliken	VERB
ecletica-285	81	11	formal	formal	ADJ
ecletica-285	81	12	charges	charge	NOUN
ecletica-285	81	13	were	be	AUX
ecletica-285	81	14	obecl	obecl	NOUN
ecletica-285	81	15	.	.	PUNCT
ecletica-285	82	1	quím	quím	PROPN
ecletica-285	82	2	.	.	PUNCT
ecletica-285	82	3	,	,	PUNCT
ecletica-285	82	4	são	são	PROPN
ecletica-285	82	5	paulo	paulo	PROPN
ecletica-285	82	6	,	,	PUNCT
ecletica-285	82	7	34(4	34(4	NUM
ecletica-285	82	8	):	):	PUNCT
ecletica-285	82	9	87	87	NUM
ecletica-285	82	10	102	102	NUM
ecletica-285	82	11	,	,	PUNCT
ecletica-285	82	12	200990	200990	NUM
ecletica-285	82	13	artigo	artigo	NOUN
ecletica-285	82	14	article	article	NOUN
ecletica-285	82	15	tained	taine	VERB
ecletica-285	82	16	by	by	ADP
ecletica-285	82	17	the	the	DET
ecletica-285	82	18	same	same	ADJ
ecletica-285	82	19	pm3	pm3	PROPN
ecletica-285	82	20	method	method	NOUN
ecletica-285	82	21	,	,	PUNCT
ecletica-285	82	22	applied	apply	VERB
ecletica-285	82	23	on	on	ADP
ecletica-285	82	24	the	the	DET
ecletica-285	82	25	optimized	optimize	VERB
ecletica-285	82	26	structures	structure	NOUN
ecletica-285	82	27	.	.	PUNCT
ecletica-285	83	1	c	c	X
ecletica-285	83	2	)	)	PUNCT
ecletica-285	83	3	ligand	ligand	NOUN
ecletica-285	83	4	-	-	PUNCT
ecletica-285	83	5	mmp1	mmp1	NOUN
ecletica-285	83	6	docking	docking	NOUN
ecletica-285	83	7	:	:	PUNCT
ecletica-285	83	8	first	first	ADV
ecletica-285	83	9	a	a	DET
ecletica-285	83	10	grid	grid	NOUN
ecletica-285	83	11	calculation	calculation	NOUN
ecletica-285	83	12	was	be	AUX
ecletica-285	83	13	run	run	VERB
ecletica-285	83	14	in	in	ADP
ecletica-285	83	15	order	order	NOUN
ecletica-285	83	16	to	to	PART
ecletica-285	83	17	determine	determine	VERB
ecletica-285	83	18	the	the	DET
ecletica-285	83	19	area	area	NOUN
ecletica-285	83	20	to	to	PART
ecletica-285	83	21	be	be	AUX
ecletica-285	83	22	searched	search	VERB
ecletica-285	83	23	to	to	PART
ecletica-285	83	24	dock	dock	VERB
ecletica-285	83	25	a	a	DET
ecletica-285	83	26	ligand	ligand	NOUN
ecletica-285	83	27	to	to	ADP
ecletica-285	83	28	the	the	DET
ecletica-285	83	29	receptor	receptor	NOUN
ecletica-285	83	30	.	.	PUNCT
ecletica-285	84	1	in	in	ADP
ecletica-285	84	2	this	this	DET
ecletica-285	84	3	case	case	NOUN
ecletica-285	84	4	,	,	PUNCT
ecletica-285	84	5	this	this	DET
ecletica-285	84	6	area	area	NOUN
ecletica-285	84	7	corresponds	correspond	VERB
ecletica-285	84	8	roughly	roughly	ADV
ecletica-285	84	9	to	to	ADP
ecletica-285	84	10	the	the	DET
ecletica-285	84	11	enzyme	enzyme	NOUN
ecletica-285	84	12	active	active	ADJ
ecletica-285	84	13	site	site	NOUN
ecletica-285	84	14	.	.	PUNCT
ecletica-285	85	1	to	to	PART
ecletica-285	85	2	perform	perform	VERB
ecletica-285	85	3	this	this	DET
ecletica-285	85	4	calculation	calculation	NOUN
ecletica-285	85	5	,	,	PUNCT
ecletica-285	85	6	we	we	PRON
ecletica-285	85	7	utilized	utilize	VERB
ecletica-285	85	8	the	the	DET
ecletica-285	85	9	known	know	VERB
ecletica-285	85	10	structure	structure	NOUN
ecletica-285	85	11	of	of	ADP
ecletica-285	85	12	the	the	DET
ecletica-285	85	13	enzyme	enzyme	NOUN
ecletica-285	85	14	co	co	NOUN
ecletica-285	85	15	-	-	VERB
ecletica-285	85	16	crystallized	crystallize	VERB
ecletica-285	85	17	with	with	ADP
ecletica-285	85	18	an	an	DET
ecletica-285	85	19	inhibitor	inhibitor	NOUN
ecletica-285	85	20	.	.	PUNCT
ecletica-285	86	1	then	then	ADV
ecletica-285	86	2	,	,	PUNCT
ecletica-285	86	3	the	the	DET
ecletica-285	86	4	dock	dock	NOUN
ecletica-285	86	5	computation	computation	NOUN
ecletica-285	86	6	generated	generate	VERB
ecletica-285	86	7	the	the	DET
ecletica-285	86	8	more	more	ADV
ecletica-285	86	9	plausible	plausible	ADJ
ecletica-285	86	10	binding	binding	ADJ
ecletica-285	86	11	modes	mode	NOUN
ecletica-285	86	12	for	for	ADP
ecletica-285	86	13	the	the	DET
ecletica-285	86	14	tested	test	VERB
ecletica-285	86	15	ligands	ligand	NOUN
ecletica-285	86	16	.	.	PUNCT
ecletica-285	87	1	once	once	ADV
ecletica-285	87	2	located	locate	VERB
ecletica-285	87	3	favorable	favorable	ADJ
ecletica-285	87	4	structures	structure	NOUN
ecletica-285	87	5	and	and	CCONJ
ecletica-285	87	6	bond	bond	NOUN
ecletica-285	87	7	conformations	conformation	NOUN
ecletica-285	87	8	,	,	PUNCT
ecletica-285	87	9	binding	bind	VERB
ecletica-285	87	10	energies	energy	NOUN
ecletica-285	87	11	for	for	ADP
ecletica-285	87	12	ligand	ligand	NOUN
ecletica-285	87	13	-	-	PUNCT
ecletica-285	87	14	receptor	receptor	NOUN
ecletica-285	87	15	pairs	pair	NOUN
ecletica-285	87	16	were	be	AUX
ecletica-285	87	17	calculated	calculate	VERB
ecletica-285	87	18	.	.	PUNCT
ecletica-285	88	1	d	d	X
ecletica-285	88	2	)	)	PUNCT
ecletica-285	88	3	total	total	ADJ
ecletica-285	88	4	binding	bind	VERB
ecletica-285	88	5	energy	energy	NOUN
ecletica-285	88	6	ligand	ligand	NOUN
ecletica-285	88	7	-	-	PUNCT
ecletica-285	88	8	enzyme	enzyme	NOUN
ecletica-285	88	9	(	(	PUNCT
ecletica-285	88	10	ebind	ebind	NOUN
ecletica-285	88	11	):	):	PUNCT
ecletica-285	88	12	this	this	DET
ecletica-285	88	13	calculation	calculation	NOUN
ecletica-285	88	14	associates	associate	VERB
ecletica-285	88	15	a	a	DET
ecletica-285	88	16	quantum	quantum	ADJ
ecletica-285	88	17	mechanical	mechanical	NOUN
ecletica-285	88	18	(	(	PUNCT
ecletica-285	88	19	qm	qm	PROPN
ecletica-285	88	20	)	)	PUNCT
ecletica-285	88	21	and	and	CCONJ
ecletica-285	88	22	a	a	DET
ecletica-285	88	23	classical	classical	ADJ
ecletica-285	88	24	molecular	molecular	ADJ
ecletica-285	88	25	mechanical	mechanical	ADJ
ecletica-285	88	26	(	(	PUNCT
ecletica-285	88	27	mm	mm	NOUN
ecletica-285	88	28	)	)	PUNCT
ecletica-285	88	29	procedures	procedure	NOUN
ecletica-285	88	30	.	.	PUNCT
ecletica-285	89	1	first	first	ADV
ecletica-285	89	2	,	,	PUNCT
ecletica-285	89	3	the	the	DET
ecletica-285	89	4	qm	qm	PROPN
ecletica-285	89	5	energy	energy	NOUN
ecletica-285	89	6	of	of	ADP
ecletica-285	89	7	the	the	DET
ecletica-285	89	8	isolated	isolated	ADJ
ecletica-285	89	9	ligand	ligand	NOUN
ecletica-285	89	10	was	be	AUX
ecletica-285	89	11	calculated	calculate	VERB
ecletica-285	89	12	by	by	ADP
ecletica-285	89	13	an	an	DET
ecletica-285	89	14	ab	ab	PROPN
ecletica-285	89	15	initio	initio	PROPN
ecletica-285	89	16	density	density	PROPN
ecletica-285	89	17	functional	functional	ADJ
ecletica-285	89	18	theory	theory	NOUN
ecletica-285	89	19	(	(	PUNCT
ecletica-285	89	20	dft	dft	NOUN
ecletica-285	89	21	)	)	PUNCT
ecletica-285	89	22	method	method	NOUN
ecletica-285	89	23	,	,	PUNCT
ecletica-285	89	24	utilizing	utilize	VERB
ecletica-285	89	25	the	the	DET
ecletica-285	89	26	software	software	NOUN
ecletica-285	89	27	jaguar	jaguar	PROPN
ecletica-285	89	28	4.1	4.1	NUM
ecletica-285	89	29	(	(	PUNCT
ecletica-285	89	30	schrödinger	schrödinger	PROPN
ecletica-285	89	31	inc	inc	PROPN
ecletica-285	89	32	.	.	PROPN
ecletica-285	89	33	)	)	PUNCT
ecletica-285	89	34	.	.	PUNCT
ecletica-285	90	1	next	next	ADV
ecletica-285	90	2	,	,	PUNCT
ecletica-285	90	3	the	the	DET
ecletica-285	90	4	energy	energy	NOUN
ecletica-285	90	5	of	of	ADP
ecletica-285	90	6	isolated	isolated	ADJ
ecletica-285	90	7	enzyme	enzyme	NOUN
ecletica-285	90	8	was	be	AUX
ecletica-285	90	9	calculated	calculate	VERB
ecletica-285	90	10	by	by	ADP
ecletica-285	90	11	a	a	DET
ecletica-285	90	12	mixed	mixed	ADJ
ecletica-285	90	13	qm	qm	PROPN
ecletica-285	90	14	/	/	SYM
ecletica-285	90	15	mm	mm	PROPN
ecletica-285	90	16	method	method	NOUN
ecletica-285	90	17	,	,	PUNCT
ecletica-285	90	18	the	the	DET
ecletica-285	90	19	same	same	ADJ
ecletica-285	90	20	ab	ab	PROPN
ecletica-285	90	21	initio	initio	PROPN
ecletica-285	90	22	dft	dft	PROPN
ecletica-285	90	23	technique	technique	NOUN
ecletica-285	90	24	for	for	ADP
ecletica-285	90	25	the	the	DET
ecletica-285	90	26	active	active	ADJ
ecletica-285	90	27	site	site	NOUN
ecletica-285	90	28	region	region	NOUN
ecletica-285	90	29	and	and	CCONJ
ecletica-285	90	30	a	a	DET
ecletica-285	90	31	mm	mm	NOUN
ecletica-285	90	32	procedure	procedure	NOUN
ecletica-285	90	33	with	with	ADP
ecletica-285	90	34	the	the	DET
ecletica-285	90	35	opls	opls	PROPN
ecletica-285	90	36	-	-	PUNCT
ecletica-285	90	37	aa	aa	PROPN
ecletica-285	90	38	force	force	NOUN
ecletica-285	90	39	field	field	NOUN
ecletica-285	90	40	for	for	ADP
ecletica-285	90	41	the	the	DET
ecletica-285	90	42	rest	rest	NOUN
ecletica-285	90	43	of	of	ADP
ecletica-285	90	44	the	the	DET
ecletica-285	90	45	protein	protein	NOUN
ecletica-285	90	46	molecule	molecule	NOUN
ecletica-285	90	47	.	.	PUNCT
ecletica-285	91	1	finally	finally	ADV
ecletica-285	91	2	,	,	PUNCT
ecletica-285	91	3	the	the	DET
ecletica-285	91	4	qm	qm	PROPN
ecletica-285	91	5	energy	energy	NOUN
ecletica-285	91	6	of	of	ADP
ecletica-285	91	7	the	the	DET
ecletica-285	91	8	ligand	ligand	NOUN
ecletica-285	91	9	and	and	CCONJ
ecletica-285	91	10	the	the	DET
ecletica-285	91	11	qm	qm	PROPN
ecletica-285	91	12	/	/	SYM
ecletica-285	91	13	mm	mm	PROPN
ecletica-285	91	14	energy	energy	NOUN
ecletica-285	91	15	of	of	ADP
ecletica-285	91	16	the	the	DET
ecletica-285	91	17	enzyme	enzyme	NOUN
ecletica-285	91	18	were	be	AUX
ecletica-285	91	19	subtracted	subtract	VERB
ecletica-285	91	20	from	from	ADP
ecletica-285	91	21	the	the	DET
ecletica-285	91	22	qm	qm	PROPN
ecletica-285	91	23	/	/	SYM
ecletica-285	91	24	mm	mm	PROPN
ecletica-285	91	25	energy	energy	NOUN
ecletica-285	91	26	of	of	ADP
ecletica-285	91	27	the	the	DET
ecletica-285	91	28	complex	complex	ADJ
ecletica-285	91	29	ligand	ligand	NOUN
ecletica-285	91	30	-	-	PUNCT
ecletica-285	91	31	enzyme	enzyme	NOUN
ecletica-285	91	32	.	.	PUNCT
ecletica-285	92	1	this	this	DET
ecletica-285	92	2	last	last	ADJ
ecletica-285	92	3	was	be	AUX
ecletica-285	92	4	calculated	calculate	VERB
ecletica-285	92	5	in	in	ADP
ecletica-285	92	6	the	the	DET
ecletica-285	92	7	same	same	ADJ
ecletica-285	92	8	way	way	NOUN
ecletica-285	92	9	that	that	PRON
ecletica-285	92	10	the	the	DET
ecletica-285	92	11	energy	energy	NOUN
ecletica-285	92	12	of	of	ADP
ecletica-285	92	13	the	the	DET
ecletica-285	92	14	enzyme	enzyme	NOUN
ecletica-285	92	15	alone	alone	ADV
ecletica-285	92	16	.	.	PUNCT
ecletica-285	93	1	ebind	ebind	NOUN
ecletica-285	93	2	=	=	SYM
ecletica-285	93	3	eqm	eqm	PROPN
ecletica-285	93	4	/	/	SYM
ecletica-285	93	5	mm	mm	PROPN
ecletica-285	93	6	cplx	cplx	PROPN
ecletica-285	93	7	eqm	eqm	PROPN
ecletica-285	93	8	lig	lig	PROPN
ecletica-285	93	9	eqm	eqm	PROPN
ecletica-285	93	10	/	/	SYM
ecletica-285	93	11	mm	mm	PROPN
ecletica-285	93	12	enz	enz	PROPN
ecletica-285	93	13	e	e	NOUN
ecletica-285	93	14	)	)	PUNCT
ecletica-285	93	15	entropy	entropy	NOUN
ecletica-285	93	16	calculation	calculation	NOUN
ecletica-285	93	17	:	:	PUNCT
ecletica-285	93	18	the	the	DET
ecletica-285	93	19	entropy	entropy	NOUN
ecletica-285	93	20	of	of	ADP
ecletica-285	93	21	human	human	ADJ
ecletica-285	93	22	collagenase	collagenase	NOUN
ecletica-285	93	23	,	,	PUNCT
ecletica-285	93	24	free	free	ADJ
ecletica-285	93	25	and	and	CCONJ
ecletica-285	93	26	bond	bond	NOUN
ecletica-285	93	27	to	to	ADP
ecletica-285	93	28	ligands	ligand	NOUN
ecletica-285	93	29	,	,	PUNCT
ecletica-285	93	30	was	be	AUX
ecletica-285	93	31	calculated	calculate	VERB
ecletica-285	93	32	to	to	PART
ecletica-285	93	33	test	test	VERB
ecletica-285	93	34	entropic	entropic	ADJ
ecletica-285	93	35	effects	effect	NOUN
ecletica-285	93	36	in	in	ADP
ecletica-285	93	37	the	the	DET
ecletica-285	93	38	interaction	interaction	NOUN
ecletica-285	93	39	enzyme	enzyme	NOUN
ecletica-285	93	40	-	-	PUNCT
ecletica-285	93	41	inhibitors	inhibitor	NOUN
ecletica-285	93	42	.	.	PUNCT
ecletica-285	94	1	two	two	NUM
ecletica-285	94	2	entropic	entropic	ADJ
ecletica-285	94	3	components	component	NOUN
ecletica-285	94	4	must	must	AUX
ecletica-285	94	5	be	be	AUX
ecletica-285	94	6	considered	consider	VERB
ecletica-285	94	7	:	:	PUNCT
ecletica-285	94	8	the	the	DET
ecletica-285	94	9	conformational	conformational	ADJ
ecletica-285	94	10	entropy	entropy	NOUN
ecletica-285	94	11	of	of	ADP
ecletica-285	94	12	the	the	DET
ecletica-285	94	13	polypeptide	polypeptide	ADJ
ecletica-285	94	14	chain	chain	NOUN
ecletica-285	94	15	and	and	CCONJ
ecletica-285	94	16	the	the	DET
ecletica-285	94	17	ordainment	ordainment	NOUN
ecletica-285	94	18	of	of	ADP
ecletica-285	94	19	water	water	NOUN
ecletica-285	94	20	molecules	molecule	NOUN
ecletica-285	94	21	around	around	ADP
ecletica-285	94	22	the	the	DET
ecletica-285	94	23	lateral	lateral	ADJ
ecletica-285	94	24	chains	chain	NOUN
ecletica-285	94	25	of	of	ADP
ecletica-285	94	26	the	the	DET
ecletica-285	94	27	amino	amino	NOUN
ecletica-285	94	28	acid	acid	NOUN
ecletica-285	94	29	residues	residue	NOUN
ecletica-285	94	30	[	[	X
ecletica-285	94	31	30	30	NUM
ecletica-285	94	32	]	]	PUNCT
ecletica-285	94	33	.	.	PUNCT
ecletica-285	95	1	let	let	VERB
ecletica-285	95	2	us	we	PRON
ecletica-285	95	3	consider	consider	VERB
ecletica-285	95	4	first	first	ADV
ecletica-285	95	5	the	the	DET
ecletica-285	95	6	ordering	ordering	NOUN
ecletica-285	95	7	of	of	ADP
ecletica-285	95	8	water	water	NOUN
ecletica-285	95	9	molecules	molecule	NOUN
ecletica-285	95	10	on	on	ADP
ecletica-285	95	11	the	the	DET
ecletica-285	95	12	surface	surface	NOUN
ecletica-285	95	13	of	of	ADP
ecletica-285	95	14	the	the	DET
ecletica-285	95	15	protein	protein	NOUN
ecletica-285	95	16	.	.	PUNCT
ecletica-285	96	1	in	in	ADP
ecletica-285	96	2	the	the	DET
ecletica-285	96	3	case	case	NOUN
ecletica-285	96	4	of	of	ADP
ecletica-285	96	5	globular	globular	ADJ
ecletica-285	96	6	proteins	protein	NOUN
ecletica-285	96	7	,	,	PUNCT
ecletica-285	96	8	as	as	ADP
ecletica-285	96	9	the	the	DET
ecletica-285	96	10	human	human	ADJ
ecletica-285	96	11	collagenase	collagenase	NOUN
ecletica-285	96	12	,	,	PUNCT
ecletica-285	96	13	this	this	DET
ecletica-285	96	14	ordering	ordering	NOUN
ecletica-285	96	15	occurs	occur	VERB
ecletica-285	96	16	mainly	mainly	ADV
ecletica-285	96	17	in	in	ADP
ecletica-285	96	18	the	the	DET
ecletica-285	96	19	external	external	ADJ
ecletica-285	96	20	surface	surface	NOUN
ecletica-285	96	21	of	of	ADP
ecletica-285	96	22	the	the	DET
ecletica-285	96	23	coil	coil	NOUN
ecletica-285	96	24	structure	structure	NOUN
ecletica-285	96	25	,	,	PUNCT
ecletica-285	96	26	which	which	PRON
ecletica-285	96	27	is	be	AUX
ecletica-285	96	28	in	in	ADP
ecletica-285	96	29	direct	direct	ADJ
ecletica-285	96	30	contact	contact	NOUN
ecletica-285	96	31	with	with	ADP
ecletica-285	96	32	aqueous	aqueous	ADJ
ecletica-285	96	33	medium	medium	NOUN
ecletica-285	96	34	.	.	PUNCT
ecletica-285	97	1	any	any	DET
ecletica-285	97	2	disturbance	disturbance	NOUN
ecletica-285	97	3	in	in	ADP
ecletica-285	97	4	this	this	DET
ecletica-285	97	5	hydration	hydration	NOUN
ecletica-285	97	6	layer	layer	NOUN
ecletica-285	97	7	,	,	PUNCT
ecletica-285	97	8	for	for	ADP
ecletica-285	97	9	example	example	NOUN
ecletica-285	97	10	,	,	PUNCT
ecletica-285	97	11	due	due	ADP
ecletica-285	97	12	to	to	ADP
ecletica-285	97	13	interaction	interaction	NOUN
ecletica-285	97	14	of	of	ADP
ecletica-285	97	15	the	the	DET
ecletica-285	97	16	protein	protein	NOUN
ecletica-285	97	17	with	with	ADP
ecletica-285	97	18	another	another	DET
ecletica-285	97	19	protein	protein	NOUN
ecletica-285	97	20	or	or	CCONJ
ecletica-285	97	21	with	with	ADP
ecletica-285	97	22	a	a	DET
ecletica-285	97	23	ligand	ligand	NOUN
ecletica-285	97	24	,	,	PUNCT
ecletica-285	97	25	decreases	decrease	VERB
ecletica-285	97	26	such	such	ADJ
ecletica-285	97	27	order	order	NOUN
ecletica-285	97	28	and	and	CCONJ
ecletica-285	97	29	increases	increase	VERB
ecletica-285	97	30	the	the	DET
ecletica-285	97	31	entropy	entropy	NOUN
ecletica-285	97	32	associated	associate	VERB
ecletica-285	97	33	with	with	ADP
ecletica-285	97	34	it	it	PRON
ecletica-285	97	35	.	.	PUNCT
ecletica-285	98	1	we	we	PRON
ecletica-285	98	2	can	can	AUX
ecletica-285	98	3	estimate	estimate	VERB
ecletica-285	98	4	the	the	DET
ecletica-285	98	5	degree	degree	NOUN
ecletica-285	98	6	of	of	ADP
ecletica-285	98	7	disturbance	disturbance	NOUN
ecletica-285	98	8	by	by	ADP
ecletica-285	98	9	calculating	calculate	VERB
ecletica-285	98	10	the	the	DET
ecletica-285	98	11	fraction	fraction	NOUN
ecletica-285	98	12	of	of	ADP
ecletica-285	98	13	surface	surface	NOUN
ecletica-285	98	14	area	area	NOUN
ecletica-285	98	15	of	of	ADP
ecletica-285	98	16	the	the	DET
ecletica-285	98	17	protein	protein	NOUN
ecletica-285	98	18	involved	involve	VERB
ecletica-285	98	19	in	in	ADP
ecletica-285	98	20	this	this	DET
ecletica-285	98	21	interaction	interaction	NOUN
ecletica-285	98	22	.	.	PUNCT
ecletica-285	99	1	we	we	PRON
ecletica-285	99	2	supposed	suppose	VERB
ecletica-285	99	3	,	,	PUNCT
ecletica-285	99	4	by	by	ADP
ecletica-285	99	5	hypothesis	hypothesis	NOUN
ecletica-285	99	6	,	,	PUNCT
ecletica-285	99	7	that	that	SCONJ
ecletica-285	99	8	this	this	DET
ecletica-285	99	9	area	area	NOUN
ecletica-285	99	10	is	be	AUX
ecletica-285	99	11	equal	equal	ADJ
ecletica-285	99	12	to	to	ADP
ecletica-285	99	13	half	half	NOUN
ecletica-285	99	14	of	of	ADP
ecletica-285	99	15	the	the	DET
ecletica-285	99	16	surface	surface	NOUN
ecletica-285	99	17	area	area	NOUN
ecletica-285	99	18	of	of	ADP
ecletica-285	99	19	the	the	DET
ecletica-285	99	20	ligand	ligand	NOUN
ecletica-285	99	21	.	.	PUNCT
ecletica-285	100	1	the	the	DET
ecletica-285	100	2	molecular	molecular	ADJ
ecletica-285	100	3	surface	surface	NOUN
ecletica-285	100	4	area	area	NOUN
ecletica-285	100	5	for	for	ADP
ecletica-285	100	6	enzyme	enzyme	NOUN
ecletica-285	100	7	and	and	CCONJ
ecletica-285	100	8	ligands	ligand	NOUN
ecletica-285	100	9	was	be	AUX
ecletica-285	100	10	calculated	calculate	VERB
ecletica-285	100	11	by	by	ADP
ecletica-285	100	12	the	the	DET
ecletica-285	100	13	grid	grid	NOUN
ecletica-285	100	14	method	method	NOUN
ecletica-285	100	15	described	describe	VERB
ecletica-285	100	16	by	by	ADP
ecletica-285	100	17	bodor	bodor	PROPN
ecletica-285	100	18	et	et	PROPN
ecletica-285	100	19	al	al	PROPN
ecletica-285	101	1	[	[	X
ecletica-285	101	2	31	31	NUM
ecletica-285	101	3	]	]	PUNCT
ecletica-285	101	4	,	,	PUNCT
ecletica-285	101	5	using	use	VERB
ecletica-285	101	6	the	the	DET
ecletica-285	101	7	atom	atom	NOUN
ecletica-285	101	8	radii	radius	NOUN
ecletica-285	101	9	of	of	ADP
ecletica-285	101	10	gavezotti	gavezotti	NOUN
ecletica-285	101	11	[	[	X
ecletica-285	101	12	32	32	NUM
ecletica-285	101	13	]	]	PUNCT
ecletica-285	101	14	and	and	CCONJ
ecletica-285	101	15	implemented	implement	VERB
ecletica-285	101	16	by	by	ADP
ecletica-285	101	17	the	the	DET
ecletica-285	101	18	program	program	NOUN
ecletica-285	101	19	chemplus	chemplus	NOUN
ecletica-285	101	20	[	[	X
ecletica-285	101	21	33	33	NUM
ecletica-285	101	22	]	]	PUNCT
ecletica-285	101	23	.	.	PUNCT
ecletica-285	102	1	the	the	DET
ecletica-285	102	2	conformational	conformational	ADJ
ecletica-285	102	3	entropy	entropy	NOUN
ecletica-285	102	4	of	of	ADP
ecletica-285	102	5	the	the	DET
ecletica-285	102	6	polypeptide	polypeptide	ADJ
ecletica-285	102	7	chain	chain	NOUN
ecletica-285	102	8	was	be	AUX
ecletica-285	102	9	calculated	calculate	VERB
ecletica-285	102	10	as	as	SCONJ
ecletica-285	102	11	follows	follow	VERB
ecletica-285	102	12	.	.	PUNCT
ecletica-285	103	1	let	let	VERB
ecletica-285	103	2	us	we	PRON
ecletica-285	103	3	consider	consider	VERB
ecletica-285	103	4	the	the	DET
ecletica-285	103	5	variation	variation	NOUN
ecletica-285	103	6	of	of	ADP
ecletica-285	103	7	gibbs	gibbs	PROPN
ecletica-285	103	8	energy	energy	NOUN
ecletica-285	103	9	:	:	PUNCT
ecletica-285	103	10	∆g	∆g	PROPN
ecletica-285	103	11	=	=	SYM
ecletica-285	103	12	∆h	∆h	PROPN
ecletica-285	103	13	t∆s	t∆s	NOUN
ecletica-285	103	14	rearranging	rearrange	VERB
ecletica-285	103	15	and	and	CCONJ
ecletica-285	103	16	calculating	calculate	VERB
ecletica-285	103	17	the	the	DET
ecletica-285	103	18	partial	partial	ADJ
ecletica-285	103	19	derivatives	derivative	NOUN
ecletica-285	103	20	in	in	ADP
ecletica-285	103	21	relation	relation	NOUN
ecletica-285	103	22	to	to	ADP
ecletica-285	103	23	temperature	temperature	NOUN
ecletica-285	103	24	:	:	PUNCT
ecletica-285	103	25	(	(	PUNCT
ecletica-285	103	26	∂t	∂t	PROPN
ecletica-285	103	27	/	/	SYM
ecletica-285	103	28	∂t	∂t	PROPN
ecletica-285	103	29	)	)	PUNCT
ecletica-285	103	30	∆s	∆s	PROPN
ecletica-285	103	31	+	+	NUM
ecletica-285	103	32	t	t	PROPN
ecletica-285	103	33	(	(	PUNCT
ecletica-285	103	34	∂∆s	∂∆s	PROPN
ecletica-285	103	35	/	/	SYM
ecletica-285	103	36	∂t	∂t	PROPN
ecletica-285	103	37	)	)	PUNCT
ecletica-285	103	38	=	=	PUNCT
ecletica-285	104	1	(	(	PUNCT
ecletica-285	104	2	∂∆g	∂∆g	X
ecletica-285	104	3	/	/	SYM
ecletica-285	104	4	∂t	∂t	PROPN
ecletica-285	104	5	)	)	PUNCT
ecletica-285	105	1	+	+	CCONJ
ecletica-285	105	2	(	(	PUNCT
ecletica-285	105	3	∂∆h	∂∆h	X
ecletica-285	105	4	/	/	SYM
ecletica-285	105	5	∂t	∂t	PROPN
ecletica-285	105	6	)	)	PUNCT
ecletica-285	105	7	the	the	DET
ecletica-285	105	8	second	second	ADJ
ecletica-285	105	9	parcels	parcel	NOUN
ecletica-285	105	10	of	of	ADP
ecletica-285	105	11	equality	equality	NOUN
ecletica-285	105	12	,	,	PUNCT
ecletica-285	105	13	both	both	DET
ecletica-285	105	14	sides	side	NOUN
ecletica-285	105	15	,	,	PUNCT
ecletica-285	105	16	equals	equal	VERB
ecletica-285	105	17	zero	zero	NUM
ecletica-285	105	18	,	,	PUNCT
ecletica-285	105	19	so	so	ADV
ecletica-285	105	20	:	:	PUNCT
ecletica-285	105	21	∆s	∆s	NOUN
ecletica-285	105	22	=	=	SYM
ecletica-285	105	23	(	(	PUNCT
ecletica-285	105	24	∂∆g	∂∆g	X
ecletica-285	105	25	/	/	SYM
ecletica-285	105	26	∂t	∂t	PROPN
ecletica-285	105	27	)	)	PUNCT
ecletica-285	105	28	thus	thus	ADV
ecletica-285	105	29	,	,	PUNCT
ecletica-285	105	30	the	the	DET
ecletica-285	105	31	entropy	entropy	NOUN
ecletica-285	105	32	can	can	AUX
ecletica-285	105	33	be	be	AUX
ecletica-285	105	34	calculated	calculate	VERB
ecletica-285	105	35	by	by	ADP
ecletica-285	105	36	the	the	DET
ecletica-285	105	37	expression	expression	NOUN
ecletica-285	105	38	above	above	ADV
ecletica-285	105	39	,	,	PUNCT
ecletica-285	105	40	provided	provide	VERB
ecletica-285	105	41	that	that	SCONJ
ecletica-285	105	42	we	we	PRON
ecletica-285	105	43	have	have	AUX
ecletica-285	105	44	the	the	DET
ecletica-285	105	45	variation	variation	NOUN
ecletica-285	105	46	of	of	ADP
ecletica-285	105	47	free	free	ADJ
ecletica-285	105	48	energy	energy	NOUN
ecletica-285	105	49	with	with	ADP
ecletica-285	105	50	temperature	temperature	NOUN
ecletica-285	105	51	.	.	PUNCT
ecletica-285	106	1	this	this	PRON
ecletica-285	106	2	was	be	AUX
ecletica-285	106	3	obtained	obtain	VERB
ecletica-285	106	4	through	through	ADP
ecletica-285	106	5	a	a	DET
ecletica-285	106	6	molecular	molecular	ADJ
ecletica-285	106	7	dynamics	dynamic	NOUN
ecletica-285	106	8	,	,	PUNCT
ecletica-285	106	9	simulating	simulate	VERB
ecletica-285	106	10	the	the	DET
ecletica-285	106	11	heating	heating	NOUN
ecletica-285	106	12	of	of	ADP
ecletica-285	106	13	the	the	DET
ecletica-285	106	14	molecule	molecule	NOUN
ecletica-285	106	15	in	in	ADP
ecletica-285	106	16	a	a	DET
ecletica-285	106	17	certain	certain	ADJ
ecletica-285	106	18	temperature	temperature	NOUN
ecletica-285	106	19	range	range	NOUN
ecletica-285	106	20	.	.	PUNCT
ecletica-285	107	1	we	we	PRON
ecletica-285	107	2	considered	consider	VERB
ecletica-285	107	3	that	that	SCONJ
ecletica-285	107	4	the	the	DET
ecletica-285	107	5	total	total	ADJ
ecletica-285	107	6	energy	energy	NOUN
ecletica-285	107	7	of	of	ADP
ecletica-285	107	8	the	the	DET
ecletica-285	107	9	system	system	NOUN
ecletica-285	107	10	varies	vary	VERB
ecletica-285	107	11	linearly	linearly	ADV
ecletica-285	107	12	with	with	ADP
ecletica-285	107	13	temperature	temperature	NOUN
ecletica-285	107	14	and	and	CCONJ
ecletica-285	107	15	that	that	SCONJ
ecletica-285	107	16	such	such	ADJ
ecletica-285	107	17	energy	energy	NOUN
ecletica-285	107	18	(	(	PUNCT
ecletica-285	107	19	sum	sum	NOUN
ecletica-285	107	20	of	of	ADP
ecletica-285	107	21	potential	potential	ADJ
ecletica-285	107	22	and	and	CCONJ
ecletica-285	107	23	kinetics	kinetic	NOUN
ecletica-285	107	24	energies	energy	NOUN
ecletica-285	107	25	)	)	PUNCT
ecletica-285	107	26	can	can	AUX
ecletica-285	107	27	represent	represent	VERB
ecletica-285	107	28	the	the	DET
ecletica-285	107	29	gibbs	gibbs	PROPN
ecletica-285	107	30	energy	energy	NOUN
ecletica-285	107	31	of	of	ADP
ecletica-285	107	32	the	the	DET
ecletica-285	107	33	system	system	NOUN
ecletica-285	107	34	.	.	PUNCT
ecletica-285	108	1	thus	thus	ADV
ecletica-285	108	2	:	:	PUNCT
ecletica-285	108	3	∆s	∆s	NOUN
ecletica-285	108	4	=	=	SYM
ecletica-285	108	5	(	(	PUNCT
ecletica-285	108	6	etf	etf	PROPN
ecletica-285	108	7	eti	eti	PROPN
ecletica-285	108	8	)	)	PUNCT
ecletica-285	108	9	/	/	PUNCT
ecletica-285	108	10	(	(	PUNCT
ecletica-285	108	11	tf	tf	INTJ
ecletica-285	108	12	ti	ti	PROPN
ecletica-285	108	13	)	)	PUNCT
ecletica-285	108	14	where	where	SCONJ
ecletica-285	108	15	i	i	PRON
ecletica-285	108	16	and	and	CCONJ
ecletica-285	108	17	f	f	PROPN
ecletica-285	108	18	mean	mean	VERB
ecletica-285	108	19	initial	initial	ADJ
ecletica-285	108	20	and	and	CCONJ
ecletica-285	108	21	final	final	ADJ
ecletica-285	108	22	states	state	NOUN
ecletica-285	108	23	.	.	PUNCT
ecletica-285	109	1	molecular	molecular	ADJ
ecletica-285	109	2	dynamics	dynamic	NOUN
ecletica-285	109	3	was	be	AUX
ecletica-285	109	4	performed	perform	VERB
ecletica-285	109	5	using	use	VERB
ecletica-285	109	6	the	the	DET
ecletica-285	109	7	module	module	NOUN
ecletica-285	109	8	hypernewton	hypernewton	NOUN
ecletica-285	109	9	of	of	ADP
ecletica-285	109	10	the	the	DET
ecletica-285	109	11	software	software	NOUN
ecletica-285	109	12	hyperchem	hyperchem	NOUN
ecletica-285	110	1	[	[	X
ecletica-285	110	2	27	27	NUM
ecletica-285	110	3	]	]	PUNCT
ecletica-285	110	4	.	.	PUNCT
ecletica-285	111	1	the	the	DET
ecletica-285	111	2	heating	heating	NOUN
ecletica-285	111	3	was	be	AUX
ecletica-285	111	4	simulated	simulate	VERB
ecletica-285	111	5	between	between	ADP
ecletica-285	111	6	0	0	NUM
ecletica-285	111	7	and	and	CCONJ
ecletica-285	111	8	300k	300k	PROPN
ecletica-285	111	9	.	.	PUNCT
ecletica-285	112	1	the	the	DET
ecletica-285	112	2	total	total	ADJ
ecletica-285	112	3	energy	energy	NOUN
ecletica-285	112	4	for	for	ADP
ecletica-285	112	5	ligands	ligand	NOUN
ecletica-285	112	6	,	,	PUNCT
ecletica-285	112	7	enzyme	enzyme	NOUN
ecletica-285	112	8	and	and	CCONJ
ecletica-285	112	9	ligand	ligand	NOUN
ecletica-285	112	10	-	-	PUNCT
ecletica-285	112	11	enzyme	enzyme	NOUN
ecletica-285	112	12	complexes	complex	NOUN
ecletica-285	112	13	was	be	AUX
ecletica-285	112	14	evaluated	evaluate	VERB
ecletica-285	112	15	by	by	ADP
ecletica-285	112	16	clasecl	clasecl	PROPN
ecletica-285	112	17	.	.	PUNCT
ecletica-285	113	1	quím	quím	PROPN
ecletica-285	113	2	.	.	PUNCT
ecletica-285	114	1	,	,	PUNCT
ecletica-285	114	2	são	são	PROPN
ecletica-285	114	3	paulo	paulo	PROPN
ecletica-285	114	4	,	,	PUNCT
ecletica-285	114	5	34(4	34(4	NUM
ecletica-285	114	6	):	):	PUNCT
ecletica-285	114	7	87	87	NUM
ecletica-285	114	8	102	102	NUM
ecletica-285	114	9	,	,	PUNCT
ecletica-285	114	10	2009	2009	NUM
ecletica-285	114	11	91	91	NUM
ecletica-285	114	12	artigo	artigo	NOUN
ecletica-285	114	13	article	article	NOUN
ecletica-285	114	14	sical	sical	ADJ
ecletica-285	114	15	molecular	molecular	ADJ
ecletica-285	114	16	mechanics	mechanic	NOUN
ecletica-285	114	17	.	.	PUNCT
ecletica-285	115	1	the	the	DET
ecletica-285	115	2	conformational	conformational	ADJ
ecletica-285	115	3	entropy	entropy	NOUN
ecletica-285	115	4	was	be	AUX
ecletica-285	115	5	calculated	calculate	VERB
ecletica-285	115	6	for	for	ADP
ecletica-285	115	7	the	the	DET
ecletica-285	115	8	free	free	ADJ
ecletica-285	115	9	enzyme	enzyme	NOUN
ecletica-285	115	10	,	,	PUNCT
ecletica-285	115	11	for	for	ADP
ecletica-285	115	12	each	each	DET
ecletica-285	115	13	ligand	ligand	NOUN
ecletica-285	115	14	and	and	CCONJ
ecletica-285	115	15	for	for	ADP
ecletica-285	115	16	the	the	DET
ecletica-285	115	17	ligands	ligand	NOUN
ecletica-285	115	18	bound	bind	VERB
ecletica-285	115	19	to	to	ADP
ecletica-285	115	20	the	the	DET
ecletica-285	115	21	enzyme	enzyme	NOUN
ecletica-285	115	22	.	.	PUNCT
ecletica-285	116	1	results	result	NOUN
ecletica-285	116	2	and	and	CCONJ
ecletica-285	116	3	discussion	discussion	NOUN
ecletica-285	116	4	kinetic	kinetic	NOUN
ecletica-285	116	5	parameters	parameter	NOUN
ecletica-285	116	6	for	for	ADP
ecletica-285	116	7	the	the	DET
ecletica-285	116	8	human	human	ADJ
ecletica-285	116	9	collagenase	collagenase	NOUN
ecletica-285	116	10	were	be	AUX
ecletica-285	116	11	obtained	obtain	VERB
ecletica-285	116	12	from	from	ADP
ecletica-285	116	13	the	the	DET
ecletica-285	116	14	plot	plot	NOUN
ecletica-285	116	15	of	of	ADP
ecletica-285	116	16	fluorescent	fluorescent	ADJ
ecletica-285	116	17	emission	emission	NOUN
ecletica-285	116	18	at	at	ADP
ecletica-285	116	19	394	394	NUM
ecletica-285	116	20	nm	nm	NOUN
ecletica-285	116	21	versus	versus	ADP
ecletica-285	116	22	mca	mca	PROPN
ecletica-285	116	23	-	-	PUNCT
ecletica-285	116	24	pro	pro	ADJ
ecletica-285	116	25	-	-	ADJ
ecletica-285	116	26	leu	leu	ADJ
ecletica-285	116	27	-	-	PUNCT
ecletica-285	116	28	gly	gly	NOUN
ecletica-285	116	29	-	-	PUNCT
ecletica-285	116	30	leu	leu	NOUN
ecletica-285	116	31	-	-	PUNCT
ecletica-285	116	32	dpa	dpa	PROPN
ecletica-285	116	33	-	-	PUNCT
ecletica-285	116	34	ala	ala	NOUN
ecletica-285	116	35	-	-	PUNCT
ecletica-285	116	36	arg	arg	NOUN
ecletica-285	116	37	-	-	PUNCT
ecletica-285	116	38	nh2	nh2	NOUN
ecletica-285	116	39	concentration	concentration	NOUN
ecletica-285	116	40	in	in	ADP
ecletica-285	116	41	µmol	µmol	PROPN
ecletica-285	116	42	/	/	SYM
ecletica-285	116	43	l.	l.	NOUN
ecletica-285	116	44	this	this	DET
ecletica-285	116	45	system	system	NOUN
ecletica-285	116	46	displays	display	VERB
ecletica-285	116	47	a	a	DET
ecletica-285	116	48	standard	standard	ADJ
ecletica-285	116	49	michaelis	michaeli	NOUN
ecletica-285	116	50	-	-	PUNCT
ecletica-285	116	51	menten	menten	VERB
ecletica-285	116	52	kinetics	kinetic	NOUN
ecletica-285	116	53	with	with	ADP
ecletica-285	116	54	a	a	DET
ecletica-285	116	55	vmax	vmax	PROPN
ecletica-285	116	56	=	=	SYM
ecletica-285	116	57	158	158	NUM
ecletica-285	116	58	arbitrary	arbitrary	ADJ
ecletica-285	116	59	units	unit	NOUN
ecletica-285	116	60	and	and	CCONJ
ecletica-285	116	61	km	km	NOUN
ecletica-285	116	62	=	=	SYM
ecletica-285	116	63	7,88	7,88	NUM
ecletica-285	116	64	µm	µm	NOUN
ecletica-285	116	65	.	.	PUNCT
ecletica-285	117	1	among	among	ADP
ecletica-285	117	2	the	the	DET
ecletica-285	117	3	tested	test	VERB
ecletica-285	117	4	drugs	drug	NOUN
ecletica-285	117	5	,	,	PUNCT
ecletica-285	117	6	all	all	DET
ecletica-285	117	7	the	the	DET
ecletica-285	117	8	oxicans	oxicans	PROPN
ecletica-285	117	9	inhibited	inhibit	VERB
ecletica-285	117	10	the	the	DET
ecletica-285	117	11	human	human	ADJ
ecletica-285	117	12	collagenase	collagenase	NOUN
ecletica-285	117	13	(	(	PUNCT
ecletica-285	117	14	fig	fig	NOUN
ecletica-285	117	15	.	.	PUNCT
ecletica-285	117	16	1	1	NUM
ecletica-285	117	17	)	)	PUNCT
ecletica-285	117	18	.	.	PUNCT
ecletica-285	118	1	0	0	NUM
ecletica-285	118	2	50	50	NUM
ecletica-285	118	3	100	100	NUM
ecletica-285	118	4	150	150	NUM
ecletica-285	118	5	200	200	NUM
ecletica-285	118	6	0	0	NUM
ecletica-285	118	7	20	20	NUM
ecletica-285	118	8	40	40	NUM
ecletica-285	118	9	60	60	NUM
ecletica-285	118	10	80	80	NUM
ecletica-285	118	11	100	100	NUM
ecletica-285	118	12	120	120	NUM
ecletica-285	118	13	meloxicam	meloxicam	NOUN
ecletica-285	118	14	piroxicam	piroxicam	NOUN
ecletica-285	118	15	tenoxicam	tenoxicam	NOUN
ecletica-285	118	16	e	e	X
ecletica-285	118	17	m	m	NOUN
ecletica-285	118	18	is	be	AUX
ecletica-285	118	19	si	si	X
ecletica-285	118	20	on	on	ADP
ecletica-285	118	21	(	(	PUNCT
ecletica-285	118	22	a	a	DET
ecletica-285	118	23	rb	rb	X
ecletica-285	118	24	itr	itr	PROPN
ecletica-285	118	25	ar	ar	PROPN
ecletica-285	118	26	y	y	PROPN
ecletica-285	118	27	un	un	PROPN
ecletica-285	119	1	its	its	PRON
ecletica-285	119	2	)	)	PUNCT
ecletica-285	120	1	[	[	X
ecletica-285	120	2	oxicam	oxicam	X
ecletica-285	120	3	]	]	X
ecletica-285	120	4	µm	µm	X
ecletica-285	120	5	fig.1	fig.1	ADJ
ecletica-285	120	6	–	–	PUNCT
ecletica-285	120	7	effect	effect	NOUN
ecletica-285	120	8	of	of	ADP
ecletica-285	120	9	oxicans	oxican	NOUN
ecletica-285	120	10	upon	upon	SCONJ
ecletica-285	120	11	activity	activity	NOUN
ecletica-285	120	12	of	of	ADP
ecletica-285	120	13	human	human	ADJ
ecletica-285	120	14	collagenase	collagenase	PROPN
ecletica-285	120	15	mmp1	mmp1	PROPN
ecletica-285	120	16	,	,	PUNCT
ecletica-285	120	17	measured	measure	VERB
ecletica-285	120	18	by	by	ADP
ecletica-285	120	19	emission	emission	NOUN
ecletica-285	120	20	at	at	ADP
ecletica-285	120	21	394	394	NUM
ecletica-285	120	22	nm	nm	NOUN
ecletica-285	120	23	of	of	ADP
ecletica-285	120	24	the	the	DET
ecletica-285	120	25	mca	mca	PROPN
ecletica-285	120	26	-	-	PUNCT
ecletica-285	120	27	pro	pro	ADJ
ecletica-285	120	28	-	-	ADJ
ecletica-285	120	29	leu	leu	ADJ
ecletica-285	120	30	-	-	PUNCT
ecletica-285	120	31	gly	gly	NOUN
ecletica-285	120	32	-	-	PUNCT
ecletica-285	120	33	leu	leu	NOUN
ecletica-285	120	34	-	-	PUNCT
ecletica-285	120	35	dpa	dpa	PROPN
ecletica-285	120	36	-	-	PUNCT
ecletica-285	120	37	ala	ala	NOUN
ecletica-285	120	38	-	-	PUNCT
ecletica-285	120	39	arg	arg	NOUN
ecletica-285	120	40	-	-	PUNCT
ecletica-285	120	41	nh2	nh2	NOUN
ecletica-285	120	42	hydrolysis	hydrolysis	NOUN
ecletica-285	120	43	product	product	NOUN
ecletica-285	120	44	.	.	PUNCT
ecletica-285	121	1	piroxicam	piroxicam	PROPN
ecletica-285	121	2	was	be	AUX
ecletica-285	121	3	the	the	DET
ecletica-285	121	4	most	most	ADV
ecletica-285	121	5	active	active	ADJ
ecletica-285	121	6	inhibitor	inhibitor	NOUN
ecletica-285	121	7	(	(	PUNCT
ecletica-285	121	8	ic50	ic50	PROPN
ecletica-285	121	9	=	=	PROPN
ecletica-285	121	10	63	63	NUM
ecletica-285	121	11	µm	µm	NOUN
ecletica-285	121	12	)	)	PUNCT
ecletica-285	121	13	,	,	PUNCT
ecletica-285	121	14	followed	follow	VERB
ecletica-285	121	15	by	by	ADP
ecletica-285	121	16	meloxicam	meloxicam	NOUN
ecletica-285	121	17	(	(	PUNCT
ecletica-285	121	18	ic50	ic50	PROPN
ecletica-285	121	19	=	=	PROPN
ecletica-285	121	20	66	66	NUM
ecletica-285	121	21	µm	µm	NOUN
ecletica-285	121	22	)	)	PUNCT
ecletica-285	121	23	and	and	CCONJ
ecletica-285	121	24	tenoxicam	tenoxicam	NOUN
ecletica-285	121	25	(	(	PUNCT
ecletica-285	121	26	ic50	ic50	PROPN
ecletica-285	121	27	=	=	PROPN
ecletica-285	121	28	91	91	NUM
ecletica-285	121	29	µm	µm	NOUN
ecletica-285	121	30	)	)	PUNCT
ecletica-285	121	31	.	.	PUNCT
ecletica-285	122	1	sodium	sodium	NOUN
ecletica-285	122	2	alendronate	alendronate	NOUN
ecletica-285	122	3	,	,	PUNCT
ecletica-285	122	4	otherwise	otherwise	ADV
ecletica-285	122	5	,	,	PUNCT
ecletica-285	122	6	enhanced	enhance	VERB
ecletica-285	122	7	the	the	DET
ecletica-285	122	8	mmp1	mmp1	NOUN
ecletica-285	122	9	activity	activity	NOUN
ecletica-285	122	10	(	(	PUNCT
ecletica-285	122	11	fig	fig	NOUN
ecletica-285	122	12	.	.	PUNCT
ecletica-285	122	13	2	2	NUM
ecletica-285	122	14	)	)	PUNCT
ecletica-285	122	15	.	.	PUNCT
ecletica-285	123	1	this	this	DET
ecletica-285	123	2	effect	effect	NOUN
ecletica-285	123	3	is	be	AUX
ecletica-285	123	4	contradictory	contradictory	ADJ
ecletica-285	123	5	with	with	ADP
ecletica-285	123	6	a	a	DET
ecletica-285	123	7	remark	remark	NOUN
ecletica-285	123	8	reported	report	VERB
ecletica-285	123	9	in	in	ADP
ecletica-285	123	10	the	the	DET
ecletica-285	123	11	literature	literature	NOUN
ecletica-285	123	12	,	,	PUNCT
ecletica-285	123	13	which	which	PRON
ecletica-285	123	14	describes	describe	VERB
ecletica-285	123	15	the	the	DET
ecletica-285	123	16	inhibiting	inhibit	VERB
ecletica-285	123	17	effect	effect	NOUN
ecletica-285	123	18	of	of	ADP
ecletica-285	123	19	bisphosphonates	bisphosphonate	NOUN
ecletica-285	123	20	upon	upon	SCONJ
ecletica-285	123	21	matrix	matrix	NOUN
ecletica-285	123	22	metalloproteinases	metalloproteinase	NOUN
ecletica-285	124	1	[	[	X
ecletica-285	124	2	22	22	NUM
ecletica-285	124	3	]	]	PUNCT
ecletica-285	124	4	.	.	PUNCT
ecletica-285	125	1	in	in	ADP
ecletica-285	125	2	this	this	DET
ecletica-285	125	3	work	work	NOUN
ecletica-285	125	4	,	,	PUNCT
ecletica-285	125	5	the	the	DET
ecletica-285	125	6	authors	author	NOUN
ecletica-285	125	7	verified	verify	VERB
ecletica-285	125	8	the	the	DET
ecletica-285	125	9	inhibiting	inhibit	VERB
ecletica-285	125	10	effect	effect	NOUN
ecletica-285	125	11	of	of	ADP
ecletica-285	125	12	various	various	ADJ
ecletica-285	125	13	bisphosphonates	bisphosphonate	NOUN
ecletica-285	125	14	on	on	ADP
ecletica-285	125	15	different	different	ADJ
ecletica-285	125	16	matrix	matrix	NOUN
ecletica-285	125	17	metalloproteases	metalloprotease	NOUN
ecletica-285	125	18	of	of	ADP
ecletica-285	125	19	human	human	ADJ
ecletica-285	125	20	conjunctive	conjunctive	ADJ
ecletica-285	125	21	tissue	tissue	NOUN
ecletica-285	125	22	matrix	matrix	NOUN
ecletica-285	125	23	.	.	PUNCT
ecletica-285	126	1	although	although	SCONJ
ecletica-285	126	2	the	the	DET
ecletica-285	126	3	alendronate	alendronate	NOUN
ecletica-285	126	4	did	do	AUX
ecletica-285	126	5	not	not	PART
ecletica-285	126	6	inhibit	inhibit	VERB
ecletica-285	126	7	human	human	ADJ
ecletica-285	126	8	collagenase	collagenase	NOUN
ecletica-285	126	9	,	,	PUNCT
ecletica-285	126	10	mmp-1	mmp-1	SCONJ
ecletica-285	126	11	,	,	PUNCT
ecletica-285	126	12	it	it	PRON
ecletica-285	126	13	inhibited	inhibit	VERB
ecletica-285	126	14	the	the	DET
ecletica-285	126	15	mmps	mmp	NOUN
ecletica-285	126	16	3	3	NUM
ecletica-285	126	17	,	,	PUNCT
ecletica-285	126	18	8	8	NUM
ecletica-285	126	19	,	,	PUNCT
ecletica-285	126	20	9	9	NUM
ecletica-285	126	21	,	,	PUNCT
ecletica-285	126	22	12	12	NUM
ecletica-285	126	23	and	and	CCONJ
ecletica-285	126	24	13	13	NUM
ecletica-285	126	25	.	.	PUNCT
ecletica-285	127	1	three	three	NUM
ecletica-285	127	2	other	other	ADJ
ecletica-285	127	3	bisphosphonates	bisphosphonate	NOUN
ecletica-285	127	4	,	,	PUNCT
ecletica-285	127	5	clondronate	clondronate	NOUN
ecletica-285	127	6	,	,	PUNCT
ecletica-285	127	7	pamidronate	pamidronate	ADJ
ecletica-285	127	8	and	and	CCONJ
ecletica-285	127	9	tilundronate	tilundronate	ADJ
ecletica-285	127	10	,	,	PUNCT
ecletica-285	127	11	inhibited	inhibit	VERB
ecletica-285	127	12	the	the	DET
ecletica-285	127	13	mmp-1	mmp-1	NOUN
ecletica-285	127	14	.	.	PUNCT
ecletica-285	128	1	no	no	PRON
ecletica-285	128	2	stimulating	stimulate	VERB
ecletica-285	128	3	or	or	CCONJ
ecletica-285	128	4	activating	activate	VERB
ecletica-285	128	5	effects	effect	NOUN
ecletica-285	128	6	were	be	AUX
ecletica-285	128	7	observed	observe	VERB
ecletica-285	128	8	in	in	ADP
ecletica-285	128	9	any	any	DET
ecletica-285	128	10	case	case	NOUN
ecletica-285	128	11	.	.	PUNCT
ecletica-285	129	1	on	on	ADP
ecletica-285	129	2	the	the	DET
ecletica-285	129	3	other	other	ADJ
ecletica-285	129	4	hand	hand	NOUN
ecletica-285	129	5	,	,	PUNCT
ecletica-285	129	6	we	we	PRON
ecletica-285	129	7	observed	observe	VERB
ecletica-285	129	8	a	a	DET
ecletica-285	129	9	similar	similar	ADJ
ecletica-285	129	10	activating	activating	ADJ
ecletica-285	129	11	effect	effect	NOUN
ecletica-285	129	12	of	of	ADP
ecletica-285	129	13	the	the	DET
ecletica-285	129	14	alendronate	alendronate	NOUN
ecletica-285	129	15	upon	upon	SCONJ
ecletica-285	129	16	the	the	DET
ecletica-285	129	17	activity	activity	NOUN
ecletica-285	129	18	of	of	ADP
ecletica-285	129	19	the	the	DET
ecletica-285	129	20	collagenase	collagenase	NOUN
ecletica-285	129	21	produced	produce	VERB
ecletica-285	129	22	by	by	ADP
ecletica-285	129	23	the	the	DET
ecletica-285	129	24	bacterium	bacterium	NOUN
ecletica-285	129	25	clostridium	clostridium	NOUN
ecletica-285	129	26	histolyticum	histolyticum	NOUN
ecletica-285	129	27	,	,	PUNCT
ecletica-285	129	28	one	one	NUM
ecletica-285	129	29	of	of	ADP
ecletica-285	129	30	the	the	DET
ecletica-285	129	31	causative	causative	ADJ
ecletica-285	129	32	agents	agent	NOUN
ecletica-285	129	33	of	of	ADP
ecletica-285	129	34	gas	gas	NOUN
ecletica-285	129	35	gangrene	gangrene	NOUN
ecletica-285	129	36	[	[	X
ecletica-285	129	37	34	34	NUM
ecletica-285	129	38	]	]	PUNCT
ecletica-285	129	39	.	.	PUNCT
ecletica-285	130	1	ecl	ecl	PROPN
ecletica-285	130	2	.	.	PROPN
ecletica-285	130	3	quím	quím	PROPN
ecletica-285	130	4	.	.	PUNCT
ecletica-285	130	5	,	,	PUNCT
ecletica-285	130	6	são	são	PROPN
ecletica-285	130	7	paulo	paulo	PROPN
ecletica-285	130	8	,	,	PUNCT
ecletica-285	130	9	34(4	34(4	NUM
ecletica-285	130	10	):	):	PUNCT
ecletica-285	130	11	87	87	NUM
ecletica-285	130	12	102	102	NUM
ecletica-285	130	13	,	,	PUNCT
ecletica-285	130	14	200992	200992	NUM
ecletica-285	130	15	artigo	artigo	NOUN
ecletica-285	130	16	article	article	NOUN
ecletica-285	130	17	0	0	NUM
ecletica-285	130	18	500	500	NUM
ecletica-285	130	19	1000	1000	NUM
ecletica-285	130	20	1500	1500	NUM
ecletica-285	130	21	2000	2000	NUM
ecletica-285	130	22	2500	2500	NUM
ecletica-285	130	23	3000	3000	NUM
ecletica-285	130	24	40	40	NUM
ecletica-285	130	25	50	50	NUM
ecletica-285	130	26	60	60	NUM
ecletica-285	130	27	70	70	NUM
ecletica-285	130	28	80	80	NUM
ecletica-285	130	29	90	90	NUM
ecletica-285	130	30	100	100	NUM
ecletica-285	130	31	110	110	NUM
ecletica-285	130	32	120	120	NUM
ecletica-285	130	33	e	e	NOUN
ecletica-285	130	34	m	m	VERB
ecletica-285	130	35	is	be	AUX
ecletica-285	130	36	si	si	X
ecletica-285	130	37	on	on	ADP
ecletica-285	130	38	(	(	PUNCT
ecletica-285	130	39	a	a	DET
ecletica-285	130	40	rb	rb	X
ecletica-285	130	41	itr	itr	PROPN
ecletica-285	130	42	ar	ar	PROPN
ecletica-285	130	43	y	y	PROPN
ecletica-285	130	44	un	un	PROPN
ecletica-285	131	1	its	its	PRON
ecletica-285	131	2	)	)	PUNCT
ecletica-285	131	3	[	[	PUNCT
ecletica-285	131	4	sodium	sodium	NOUN
ecletica-285	131	5	alendronate	alendronate	NOUN
ecletica-285	131	6	]	]	PUNCT
ecletica-285	131	7	µm	µm	ADP
ecletica-285	131	8	fig.2	fig.2	PROPN
ecletica-285	131	9	–	–	PUNCT
ecletica-285	131	10	effect	effect	NOUN
ecletica-285	131	11	of	of	ADP
ecletica-285	131	12	sodium	sodium	NOUN
ecletica-285	131	13	alendronate	alendronate	VERB
ecletica-285	131	14	upon	upon	SCONJ
ecletica-285	131	15	activity	activity	NOUN
ecletica-285	131	16	of	of	ADP
ecletica-285	131	17	human	human	ADJ
ecletica-285	131	18	collagenase	collagenase	PROPN
ecletica-285	131	19	mmp1	mmp1	PROPN
ecletica-285	131	20	,	,	PUNCT
ecletica-285	131	21	measured	measure	VERB
ecletica-285	131	22	by	by	ADP
ecletica-285	131	23	emission	emission	NOUN
ecletica-285	131	24	at	at	ADP
ecletica-285	131	25	394	394	NUM
ecletica-285	131	26	nm	nm	NOUN
ecletica-285	131	27	of	of	ADP
ecletica-285	131	28	the	the	DET
ecletica-285	131	29	mca	mca	PROPN
ecletica-285	131	30	-	-	PUNCT
ecletica-285	131	31	pro	pro	ADJ
ecletica-285	131	32	-	-	ADJ
ecletica-285	131	33	leu	leu	ADJ
ecletica-285	131	34	-	-	PUNCT
ecletica-285	131	35	gly	gly	NOUN
ecletica-285	131	36	-	-	PUNCT
ecletica-285	131	37	leu	leu	NOUN
ecletica-285	131	38	-	-	PUNCT
ecletica-285	131	39	dpa	dpa	PROPN
ecletica-285	131	40	-	-	PUNCT
ecletica-285	131	41	ala	ala	NOUN
ecletica-285	131	42	-	-	PUNCT
ecletica-285	131	43	arg	arg	NOUN
ecletica-285	131	44	-	-	PUNCT
ecletica-285	131	45	nh2	nh2	NOUN
ecletica-285	131	46	hydrolysis	hydrolysis	NOUN
ecletica-285	131	47	product	product	NOUN
ecletica-285	131	48	.	.	PUNCT
ecletica-285	132	1	docking	dock	VERB
ecletica-285	132	2	calculations	calculation	NOUN
ecletica-285	132	3	defined	define	VERB
ecletica-285	132	4	the	the	DET
ecletica-285	132	5	best	good	ADJ
ecletica-285	132	6	geometry	geometry	NOUN
ecletica-285	132	7	for	for	ADP
ecletica-285	132	8	ligand	ligand	NOUN
ecletica-285	132	9	-	-	PUNCT
ecletica-285	132	10	enzyme	enzyme	NOUN
ecletica-285	132	11	interaction	interaction	NOUN
ecletica-285	132	12	.	.	PUNCT
ecletica-285	133	1	the	the	DET
ecletica-285	133	2	best	good	ADJ
ecletica-285	133	3	poses	pose	NOUN
ecletica-285	133	4	between	between	ADP
ecletica-285	133	5	each	each	DET
ecletica-285	133	6	ligand	ligand	NOUN
ecletica-285	133	7	and	and	CCONJ
ecletica-285	133	8	collagenase	collagenase	VERB
ecletica-285	133	9	active	active	ADJ
ecletica-285	133	10	site	site	NOUN
ecletica-285	133	11	were	be	AUX
ecletica-285	133	12	select	select	ADJ
ecletica-285	133	13	.	.	PUNCT
ecletica-285	134	1	as	as	ADP
ecletica-285	134	2	example	example	NOUN
ecletica-285	134	3	,	,	PUNCT
ecletica-285	134	4	figure	figure	NOUN
ecletica-285	134	5	3	3	NUM
ecletica-285	134	6	shows	show	NOUN
ecletica-285	134	7	piroxicam	piroxicam	VERB
ecletica-285	134	8	,	,	PUNCT
ecletica-285	134	9	the	the	DET
ecletica-285	134	10	best	good	ADJ
ecletica-285	134	11	inhibitor	inhibitor	NOUN
ecletica-285	134	12	among	among	ADP
ecletica-285	134	13	the	the	DET
ecletica-285	134	14	tested	test	VERB
ecletica-285	134	15	oxicans	oxican	NOUN
ecletica-285	134	16	,	,	PUNCT
ecletica-285	134	17	bound	bind	VERB
ecletica-285	134	18	to	to	ADP
ecletica-285	134	19	mmp-1	mmp-1	NOUN
ecletica-285	134	20	active	active	ADJ
ecletica-285	134	21	site	site	NOUN
ecletica-285	134	22	.	.	PUNCT
ecletica-285	135	1	ecl	ecl	PROPN
ecletica-285	135	2	.	.	PROPN
ecletica-285	135	3	quím	quím	PROPN
ecletica-285	135	4	.	.	PUNCT
ecletica-285	135	5	,	,	PUNCT
ecletica-285	135	6	são	são	PROPN
ecletica-285	135	7	paulo	paulo	PROPN
ecletica-285	135	8	,	,	PUNCT
ecletica-285	135	9	34(4	34(4	NUM
ecletica-285	135	10	):	):	PUNCT
ecletica-285	135	11	87	87	NUM
ecletica-285	135	12	102	102	NUM
ecletica-285	135	13	,	,	PUNCT
ecletica-285	135	14	2009	2009	NUM
ecletica-285	135	15	93	93	NUM
ecletica-285	135	16	artigo	artigo	PROPN
ecletica-285	135	17	article	article	NOUN
ecletica-285	135	18	fig	fig	NOUN
ecletica-285	135	19	.	.	PUNCT
ecletica-285	136	1	3	3	NUM
ecletica-285	136	2	piroxicam	piroxicam	NOUN
ecletica-285	136	3	bound	bind	VERB
ecletica-285	136	4	to	to	ADP
ecletica-285	136	5	human	human	ADJ
ecletica-285	136	6	collagenase	collagenase	NOUN
ecletica-285	136	7	active	active	PROPN
ecletica-285	136	8	site	site	NOUN
ecletica-285	136	9	.	.	PUNCT
ecletica-285	137	1	note	note	VERB
ecletica-285	137	2	the	the	DET
ecletica-285	137	3	two	two	NUM
ecletica-285	137	4	hydrogen	hydrogen	NOUN
ecletica-285	137	5	bonds	bond	NOUN
ecletica-285	137	6	between	between	ADP
ecletica-285	137	7	the	the	DET
ecletica-285	137	8	ligand	ligand	NOUN
ecletica-285	137	9	and	and	CCONJ
ecletica-285	137	10	the	the	DET
ecletica-285	137	11	oxygen	oxygen	NOUN
ecletica-285	137	12	bound	bind	VERB
ecletica-285	137	13	to	to	ADP
ecletica-285	137	14	catalytic	catalytic	ADJ
ecletica-285	137	15	zn2	zn2	PROPN
ecletica-285	137	16	+	+	PROPN
ecletica-285	137	17	.	.	PUNCT
ecletica-285	138	1	such	such	ADJ
ecletica-285	138	2	simulation	simulation	NOUN
ecletica-285	138	3	suggests	suggest	VERB
ecletica-285	138	4	the	the	DET
ecletica-285	138	5	probable	probable	ADJ
ecletica-285	138	6	chemical	chemical	NOUN
ecletica-285	138	7	interactions	interaction	NOUN
ecletica-285	138	8	between	between	ADP
ecletica-285	138	9	the	the	DET
ecletica-285	138	10	oxicans	oxicans	PROPN
ecletica-285	138	11	and	and	CCONJ
ecletica-285	138	12	the	the	DET
ecletica-285	138	13	mmp1	mmp1	PROPN
ecletica-285	138	14	active	active	ADJ
ecletica-285	138	15	site	site	NOUN
ecletica-285	138	16	.	.	PUNCT
ecletica-285	139	1	all	all	PRON
ecletica-285	139	2	of	of	ADP
ecletica-285	139	3	them	they	PRON
ecletica-285	139	4	bind	bind	VERB
ecletica-285	139	5	through	through	ADP
ecletica-285	139	6	hydrogen	hydrogen	NOUN
ecletica-285	139	7	bonds	bond	NOUN
ecletica-285	139	8	to	to	ADP
ecletica-285	139	9	the	the	DET
ecletica-285	139	10	oxygen	oxygen	NOUN
ecletica-285	139	11	coordinated	coordinate	VERB
ecletica-285	139	12	to	to	ADP
ecletica-285	139	13	the	the	DET
ecletica-285	139	14	catalytic	catalytic	ADJ
ecletica-285	139	15	zinc	zinc	NOUN
ecletica-285	139	16	(	(	PUNCT
ecletica-285	139	17	fig	fig	NOUN
ecletica-285	139	18	.	.	PUNCT
ecletica-285	139	19	4	4	NUM
ecletica-285	139	20	)	)	PUNCT
ecletica-285	139	21	.	.	PUNCT
ecletica-285	140	1	ecl	ecl	PROPN
ecletica-285	140	2	.	.	PROPN
ecletica-285	140	3	quím	quím	PROPN
ecletica-285	140	4	.	.	PUNCT
ecletica-285	140	5	,	,	PUNCT
ecletica-285	140	6	são	são	PROPN
ecletica-285	140	7	paulo	paulo	PROPN
ecletica-285	140	8	,	,	PUNCT
ecletica-285	140	9	34(4	34(4	NUM
ecletica-285	140	10	):	):	PUNCT
ecletica-285	140	11	87	87	NUM
ecletica-285	140	12	102	102	NUM
ecletica-285	140	13	,	,	PUNCT
ecletica-285	140	14	200994	200994	NUM
ecletica-285	140	15	artigo	artigo	PROPN
ecletica-285	140	16	article	article	NOUN
ecletica-285	140	17	a	a	PRON
ecletica-285	140	18	)	)	PUNCT
ecletica-285	140	19	piroxicam	piroxicam	ADJ
ecletica-285	140	20	detail	detail	NOUN
ecletica-285	140	21	:	:	PUNCT
ecletica-285	141	1	o	o	NOUN
ecletica-285	141	2	h	h	NOUN
ecletica-285	142	1	o	o	X
ecletica-285	143	1	hn	hn	INTJ
ecletica-285	143	2	zn	zn	PROPN
ecletica-285	143	3	his	his	PRON
ecletica-285	143	4	218	218	NUM
ecletica-285	143	5	his	his	PRON
ecletica-285	143	6	222	222	NUM
ecletica-285	144	1	his	his	PRON
ecletica-285	144	2	228	228	NUM
ecletica-285	144	3	1.726	1.726	NUM
ecletica-285	144	4	2,049	2,049	NUM
ecletica-285	144	5	164,3	164,3	NUM
ecletica-285	144	6	o	o	NOUN
ecletica-285	144	7	126,5o	126,5o	NUM
ecletica-285	144	8	ecl	ecl	PROPN
ecletica-285	144	9	.	.	PROPN
ecletica-285	144	10	quím	quím	PROPN
ecletica-285	144	11	.	.	PUNCT
ecletica-285	145	1	,	,	PUNCT
ecletica-285	145	2	são	são	PROPN
ecletica-285	145	3	paulo	paulo	PROPN
ecletica-285	145	4	,	,	PUNCT
ecletica-285	145	5	34(4	34(4	NUM
ecletica-285	145	6	):	):	PUNCT
ecletica-285	145	7	87	87	NUM
ecletica-285	145	8	102	102	NUM
ecletica-285	145	9	,	,	PUNCT
ecletica-285	145	10	2009	2009	NUM
ecletica-285	145	11	95	95	NUM
ecletica-285	145	12	artigo	artigo	NOUN
ecletica-285	145	13	article	article	NOUN
ecletica-285	145	14	b	b	NOUN
ecletica-285	145	15	)	)	PUNCT
ecletica-285	145	16	meloxicam	meloxicam	NOUN
ecletica-285	145	17	detail	detail	NOUN
ecletica-285	145	18	:	:	PUNCT
ecletica-285	146	1	o	o	NOUN
ecletica-285	146	2	h	h	NOUN
ecletica-285	147	1	o	o	X
ecletica-285	147	2	hn	hn	NOUN
ecletica-285	148	1	1,687	1,687	NUM
ecletica-285	148	2	1,975	1,975	NUM
ecletica-285	148	3	169,5	169,5	NUM
ecletica-285	148	4	o	o	NOUN
ecletica-285	148	5	123,8o	123,8o	NUM
ecletica-285	148	6	zn	zn	X
ecletica-285	148	7	his	his	PRON
ecletica-285	148	8	218	218	NUM
ecletica-285	148	9	his	his	PRON
ecletica-285	148	10	222	222	NUM
ecletica-285	149	1	his	his	PRON
ecletica-285	149	2	228	228	NUM
ecletica-285	149	3	ecl	ecl	PROPN
ecletica-285	149	4	.	.	PROPN
ecletica-285	149	5	quím	quím	PROPN
ecletica-285	149	6	.	.	PUNCT
ecletica-285	149	7	,	,	PUNCT
ecletica-285	149	8	são	são	PROPN
ecletica-285	149	9	paulo	paulo	PROPN
ecletica-285	149	10	,	,	PUNCT
ecletica-285	149	11	34(4	34(4	NUM
ecletica-285	149	12	):	):	PUNCT
ecletica-285	149	13	87	87	NUM
ecletica-285	149	14	102	102	NUM
ecletica-285	149	15	,	,	PUNCT
ecletica-285	149	16	200996	200996	NUM
ecletica-285	149	17	artigo	artigo	NOUN
ecletica-285	149	18	article	article	NOUN
ecletica-285	149	19	c	c	NOUN
ecletica-285	149	20	)	)	PUNCT
ecletica-285	149	21	tenoxicam	tenoxicam	NOUN
ecletica-285	149	22	detail	detail	NOUN
ecletica-285	149	23	:	:	PUNCT
ecletica-285	149	24	fig	fig	NOUN
ecletica-285	149	25	.	.	PUNCT
ecletica-285	150	1	4	4	NUM
ecletica-285	150	2	hydrogen	hydrogen	NOUN
ecletica-285	150	3	bonds	bond	NOUN
ecletica-285	150	4	(	(	PUNCT
ecletica-285	150	5	hb	hb	X
ecletica-285	150	6	)	)	PUNCT
ecletica-285	150	7	between	between	ADP
ecletica-285	150	8	the	the	DET
ecletica-285	150	9	oxicans	oxicans	PROPN
ecletica-285	150	10	and	and	CCONJ
ecletica-285	150	11	mmp-1	mmp-1	ADP
ecletica-285	150	12	active	active	ADJ
ecletica-285	150	13	site	site	NOUN
ecletica-285	150	14	.	.	PUNCT
ecletica-285	151	1	distances	distance	NOUN
ecletica-285	151	2	in	in	ADP
ecletica-285	151	3	ångströms	ångström	NOUN
ecletica-285	151	4	and	and	CCONJ
ecletica-285	151	5	angles	angle	NOUN
ecletica-285	151	6	in	in	ADP
ecletica-285	151	7	degrees	degree	NOUN
ecletica-285	151	8	.	.	PUNCT
ecletica-285	152	1	as	as	SCONJ
ecletica-285	152	2	cited	cite	VERB
ecletica-285	152	3	in	in	ADP
ecletica-285	152	4	the	the	DET
ecletica-285	152	5	introduction	introduction	NOUN
ecletica-285	152	6	section	section	NOUN
ecletica-285	152	7	,	,	PUNCT
ecletica-285	152	8	the	the	DET
ecletica-285	152	9	zn2	zn2	PROPN
ecletica-285	152	10	+	+	X
ecletica-285	152	11	involved	involve	VERB
ecletica-285	152	12	in	in	ADP
ecletica-285	152	13	the	the	DET
ecletica-285	152	14	catalytic	catalytic	ADJ
ecletica-285	152	15	process	process	NOUN
ecletica-285	152	16	coordinates	coordinate	NOUN
ecletica-285	152	17	to	to	ADP
ecletica-285	152	18	three	three	NUM
ecletica-285	152	19	residues	residue	NOUN
ecletica-285	152	20	of	of	ADP
ecletica-285	152	21	histidine	histidine	NOUN
ecletica-285	152	22	and	and	CCONJ
ecletica-285	152	23	to	to	ADP
ecletica-285	152	24	one	one	NUM
ecletica-285	152	25	molecule	molecule	NOUN
ecletica-285	152	26	of	of	ADP
ecletica-285	152	27	water	water	NOUN
ecletica-285	152	28	,	,	PUNCT
ecletica-285	152	29	through	through	ADP
ecletica-285	152	30	its	its	PRON
ecletica-285	152	31	oxygen	oxygen	NOUN
ecletica-285	152	32	.	.	PUNCT
ecletica-285	153	1	the	the	DET
ecletica-285	153	2	docking	dock	VERB
ecletica-285	153	3	simulation	simulation	NOUN
ecletica-285	153	4	of	of	ADP
ecletica-285	153	5	piroxicam	piroxicam	PROPN
ecletica-285	153	6	and	and	CCONJ
ecletica-285	153	7	meloxicam	meloxicam	NOUN
ecletica-285	153	8	with	with	ADP
ecletica-285	153	9	mmp1	mmp1	PROPN
ecletica-285	153	10	showed	show	VERB
ecletica-285	153	11	the	the	DET
ecletica-285	153	12	formation	formation	NOUN
ecletica-285	153	13	of	of	ADP
ecletica-285	153	14	two	two	NUM
ecletica-285	153	15	hydrogen	hydrogen	NOUN
ecletica-285	153	16	bonds	bond	NOUN
ecletica-285	153	17	between	between	ADP
ecletica-285	153	18	the	the	DET
ecletica-285	153	19	groups	group	NOUN
ecletica-285	153	20	n	n	CCONJ
ecletica-285	153	21	-	-	PUNCT
ecletica-285	153	22	h	h	NOUN
ecletica-285	153	23	and	and	CCONJ
ecletica-285	153	24	o	o	NOUN
ecletica-285	153	25	-	-	NOUN
ecletica-285	153	26	h	h	NOUN
ecletica-285	153	27	of	of	ADP
ecletica-285	153	28	the	the	DET
ecletica-285	153	29	oxicans	oxicans	PROPN
ecletica-285	153	30	ecl	ecl	PROPN
ecletica-285	153	31	.	.	PROPN
ecletica-285	153	32	quím	quím	PROPN
ecletica-285	153	33	.	.	PUNCT
ecletica-285	154	1	,	,	PUNCT
ecletica-285	154	2	são	são	PROPN
ecletica-285	154	3	paulo	paulo	PROPN
ecletica-285	154	4	,	,	PUNCT
ecletica-285	154	5	34(4	34(4	NUM
ecletica-285	154	6	):	):	PUNCT
ecletica-285	154	7	87	87	NUM
ecletica-285	154	8	102	102	NUM
ecletica-285	154	9	,	,	PUNCT
ecletica-285	154	10	2009	2009	NUM
ecletica-285	154	11	97	97	NUM
ecletica-285	154	12	artigo	artigo	NOUN
ecletica-285	154	13	article	article	NOUN
ecletica-285	154	14	and	and	CCONJ
ecletica-285	154	15	the	the	DET
ecletica-285	154	16	o	o	NOUN
ecletica-285	154	17	coordinated	coordinate	VERB
ecletica-285	154	18	to	to	ADP
ecletica-285	154	19	zn2	zn2	PROPN
ecletica-285	154	20	+	+	CCONJ
ecletica-285	154	21	(	(	PUNCT
ecletica-285	154	22	fig	fig	NOUN
ecletica-285	154	23	.	.	PUNCT
ecletica-285	155	1	4a	4a	NUM
ecletica-285	155	2	,	,	PUNCT
ecletica-285	155	3	b	b	NOUN
ecletica-285	155	4	)	)	PUNCT
ecletica-285	155	5	.	.	PUNCT
ecletica-285	156	1	for	for	ADP
ecletica-285	156	2	the	the	DET
ecletica-285	156	3	tenoxicam	tenoxicam	NOUN
ecletica-285	156	4	the	the	DET
ecletica-285	156	5	calculation	calculation	NOUN
ecletica-285	156	6	suggested	suggest	VERB
ecletica-285	156	7	a	a	DET
ecletica-285	156	8	different	different	ADJ
ecletica-285	156	9	interaction	interaction	NOUN
ecletica-285	156	10	schema	schema	NOUN
ecletica-285	156	11	:	:	PUNCT
ecletica-285	156	12	first	first	ADV
ecletica-285	156	13	,	,	PUNCT
ecletica-285	156	14	a	a	DET
ecletica-285	156	15	hydrogen	hydrogen	NOUN
ecletica-285	156	16	bond	bond	NOUN
ecletica-285	156	17	between	between	ADP
ecletica-285	156	18	the	the	DET
ecletica-285	156	19	o	o	NOUN
ecletica-285	156	20	-	-	NOUN
ecletica-285	156	21	h	h	NOUN
ecletica-285	156	22	and	and	CCONJ
ecletica-285	156	23	o	o	NOUN
ecletica-285	156	24	-	-	PUNCT
ecletica-285	156	25	zn	zn	X
ecletica-285	156	26	,	,	PUNCT
ecletica-285	156	27	as	as	ADP
ecletica-285	156	28	in	in	ADP
ecletica-285	156	29	the	the	DET
ecletica-285	156	30	two	two	NUM
ecletica-285	156	31	others	other	NOUN
ecletica-285	156	32	oxicans	oxican	NOUN
ecletica-285	156	33	;	;	PUNCT
ecletica-285	156	34	second	second	X
ecletica-285	156	35	,	,	PUNCT
ecletica-285	156	36	absence	absence	NOUN
ecletica-285	156	37	of	of	ADP
ecletica-285	156	38	the	the	DET
ecletica-285	156	39	bond	bond	NOUN
ecletica-285	156	40	between	between	ADP
ecletica-285	156	41	n	n	NOUN
ecletica-285	156	42	-	-	PUNCT
ecletica-285	156	43	h	h	NOUN
ecletica-285	156	44	and	and	CCONJ
ecletica-285	156	45	o	o	PROPN
ecletica-285	156	46	-	-	PROPN
ecletica-285	156	47	zn	zn	PROPN
ecletica-285	156	48	(	(	PUNCT
ecletica-285	156	49	angle	angle	NOUN
ecletica-285	156	50	and	and	CCONJ
ecletica-285	156	51	distance	distance	NOUN
ecletica-285	156	52	unfavorable	unfavorable	ADJ
ecletica-285	156	53	)	)	PUNCT
ecletica-285	156	54	;	;	PUNCT
ecletica-285	156	55	third	third	X
ecletica-285	156	56	,	,	PUNCT
ecletica-285	156	57	more	more	ADV
ecletica-285	156	58	three	three	NUM
ecletica-285	156	59	hydrogen	hydrogen	NOUN
ecletica-285	156	60	bonds	bond	NOUN
ecletica-285	156	61	involving	involve	VERB
ecletica-285	156	62	groups	group	NOUN
ecletica-285	156	63	of	of	ADP
ecletica-285	156	64	tenoxicam	tenoxicam	NOUN
ecletica-285	156	65	and	and	CCONJ
ecletica-285	156	66	amino	amino	ADJ
ecletica-285	156	67	acids	acid	NOUN
ecletica-285	156	68	residues	residue	NOUN
ecletica-285	156	69	of	of	ADP
ecletica-285	156	70	mmp-1	mmp-1	NOUN
ecletica-285	156	71	,	,	PUNCT
ecletica-285	156	72	namely	namely	ADV
ecletica-285	156	73	:	:	PUNCT
ecletica-285	156	74	n	n	NUM
ecletica-285	156	75	-	-	PUNCT
ecletica-285	156	76	h	h	NOUN
ecletica-285	156	77	with	with	ADP
ecletica-285	156	78	o	o	NOUN
ecletica-285	156	79	=	=	X
ecletica-285	156	80	c	c	PROPN
ecletica-285	156	81	of	of	ADP
ecletica-285	156	82	ala	ala	PROPN
ecletica-285	156	83	182	182	NUM
ecletica-285	156	84	,	,	PUNCT
ecletica-285	156	85	s	s	NOUN
ecletica-285	156	86	=	=	NOUN
ecletica-285	156	87	o	o	NOUN
ecletica-285	156	88	with	with	ADP
ecletica-285	156	89	h	h	NOUN
ecletica-285	156	90	-	-	PUNCT
ecletica-285	156	91	n	n	NOUN
ecletica-285	156	92	of	of	ADP
ecletica-285	156	93	his	his	PRON
ecletica-285	156	94	183	183	NUM
ecletica-285	156	95	,	,	PUNCT
ecletica-285	156	96	and	and	CCONJ
ecletica-285	156	97	s	s	X
ecletica-285	156	98	=	=	NOUN
ecletica-285	156	99	o	o	X
ecletica-285	156	100	with	with	ADP
ecletica-285	156	101	h	h	NOUN
ecletica-285	156	102	-	-	PUNCT
ecletica-285	156	103	n	n	NOUN
ecletica-285	156	104	of	of	ADP
ecletica-285	156	105	asn	asn	PROPN
ecletica-285	156	106	180	180	NUM
ecletica-285	156	107	(	(	PUNCT
ecletica-285	156	108	fig	fig	NOUN
ecletica-285	156	109	.	.	PUNCT
ecletica-285	157	1	4c	4c	NOUN
ecletica-285	157	2	)	)	PUNCT
ecletica-285	157	3	.	.	PUNCT
ecletica-285	158	1	the	the	DET
ecletica-285	158	2	docking	docking	NOUN
ecletica-285	158	3	calculation	calculation	NOUN
ecletica-285	158	4	between	between	ADP
ecletica-285	158	5	sodium	sodium	NOUN
ecletica-285	158	6	alendronate	alendronate	NOUN
ecletica-285	158	7	and	and	CCONJ
ecletica-285	158	8	mmp-1	mmp-1	ADP
ecletica-285	158	9	indicated	indicate	VERB
ecletica-285	158	10	the	the	DET
ecletica-285	158	11	impossibility	impossibility	NOUN
ecletica-285	158	12	to	to	PART
ecletica-285	158	13	form	form	VERB
ecletica-285	158	14	a	a	DET
ecletica-285	158	15	hydrogen	hydrogen	NOUN
ecletica-285	158	16	bond	bond	NOUN
ecletica-285	158	17	between	between	ADP
ecletica-285	158	18	this	this	DET
ecletica-285	158	19	ligand	ligand	NOUN
ecletica-285	158	20	and	and	CCONJ
ecletica-285	158	21	the	the	DET
ecletica-285	158	22	oxygen	oxygen	NOUN
ecletica-285	158	23	linked	link	VERB
ecletica-285	158	24	to	to	ADP
ecletica-285	158	25	zinc	zinc	NOUN
ecletica-285	158	26	,	,	PUNCT
ecletica-285	158	27	confirming	confirm	VERB
ecletica-285	158	28	the	the	DET
ecletica-285	158	29	importance	importance	NOUN
ecletica-285	158	30	of	of	ADP
ecletica-285	158	31	such	such	ADJ
ecletica-285	158	32	interaction	interaction	NOUN
ecletica-285	158	33	for	for	ADP
ecletica-285	158	34	the	the	DET
ecletica-285	158	35	enzyme	enzyme	NOUN
ecletica-285	158	36	inhibition	inhibition	NOUN
ecletica-285	158	37	,	,	PUNCT
ecletica-285	158	38	as	as	SCONJ
ecletica-285	158	39	the	the	DET
ecletica-285	158	40	alendronate	alendronate	NOUN
ecletica-285	158	41	does	do	AUX
ecletica-285	158	42	not	not	PART
ecletica-285	158	43	inhibit	inhibit	VERB
ecletica-285	158	44	this	this	DET
ecletica-285	158	45	enzyme	enzyme	NOUN
ecletica-285	158	46	.	.	PUNCT
ecletica-285	159	1	the	the	DET
ecletica-285	159	2	highest	high	ADJ
ecletica-285	159	3	intensity	intensity	NOUN
ecletica-285	159	4	of	of	ADP
ecletica-285	159	5	inhibition	inhibition	NOUN
ecletica-285	159	6	of	of	ADP
ecletica-285	159	7	piroxicam	piroxicam	NOUN
ecletica-285	159	8	and	and	CCONJ
ecletica-285	159	9	meloxicam	meloxicam	NOUN
ecletica-285	159	10	compared	compare	VERB
ecletica-285	159	11	to	to	ADP
ecletica-285	159	12	tenoxicam	tenoxicam	NOUN
ecletica-285	159	13	also	also	ADV
ecletica-285	159	14	coincides	coincide	VERB
ecletica-285	159	15	with	with	ADP
ecletica-285	159	16	a	a	DET
ecletica-285	159	17	weaker	weak	ADJ
ecletica-285	159	18	interaction	interaction	NOUN
ecletica-285	159	19	of	of	ADP
ecletica-285	159	20	the	the	DET
ecletica-285	159	21	latter	latter	ADJ
ecletica-285	159	22	(	(	PUNCT
ecletica-285	159	23	longer	long	ADJ
ecletica-285	159	24	bond	bond	NOUN
ecletica-285	159	25	and	and	CCONJ
ecletica-285	159	26	only	only	ADV
ecletica-285	159	27	one	one	NUM
ecletica-285	159	28	)	)	PUNCT
ecletica-285	159	29	with	with	ADP
ecletica-285	159	30	the	the	DET
ecletica-285	159	31	oxygen	oxygen	NOUN
ecletica-285	159	32	bonded	bond	VERB
ecletica-285	159	33	to	to	ADP
ecletica-285	159	34	catalytic	catalytic	ADJ
ecletica-285	159	35	zinc	zinc	NOUN
ecletica-285	159	36	.	.	PUNCT
ecletica-285	160	1	the	the	DET
ecletica-285	160	2	angle	angle	NOUN
ecletica-285	160	3	o	o	X
ecletica-285	160	4			PROPN
ecletica-285	160	5	h	h	NOUN
ecletica-285	160	6	......	......	PUNCT
ecletica-285	161	1	o	o	NOUN
ecletica-285	161	2	of	of	ADP
ecletica-285	161	3	this	this	DET
ecletica-285	161	4	hydrogen	hydrogen	NOUN
ecletica-285	161	5	bond	bond	NOUN
ecletica-285	161	6	is	be	AUX
ecletica-285	161	7	smaller	small	ADJ
ecletica-285	161	8	than	than	ADP
ecletica-285	161	9	the	the	DET
ecletica-285	161	10	analog	analog	NOUN
ecletica-285	161	11	for	for	ADP
ecletica-285	161	12	piroxicam	piroxicam	NOUN
ecletica-285	161	13	and	and	CCONJ
ecletica-285	161	14	meloxicam	meloxicam	PROPN
ecletica-285	161	15	,	,	PUNCT
ecletica-285	161	16	which	which	PRON
ecletica-285	161	17	also	also	ADV
ecletica-285	161	18	contributes	contribute	VERB
ecletica-285	161	19	to	to	ADP
ecletica-285	161	20	the	the	DET
ecletica-285	161	21	weakening	weakening	NOUN
ecletica-285	161	22	of	of	ADP
ecletica-285	161	23	the	the	DET
ecletica-285	161	24	bond	bond	NOUN
ecletica-285	161	25	.	.	PUNCT
ecletica-285	162	1	the	the	DET
ecletica-285	162	2	calculated	calculate	VERB
ecletica-285	162	3	total	total	ADJ
ecletica-285	162	4	bond	bond	NOUN
ecletica-285	162	5	energies	energy	NOUN
ecletica-285	162	6	reinforce	reinforce	VERB
ecletica-285	162	7	this	this	DET
ecletica-285	162	8	conclusion	conclusion	NOUN
ecletica-285	162	9	:	:	PUNCT
ecletica-285	162	10	its	its	PRON
ecletica-285	162	11	absolute	absolute	ADJ
ecletica-285	162	12	value	value	NOUN
ecletica-285	162	13	for	for	ADP
ecletica-285	162	14	tenoxicammmp-1	tenoxicammmp-1	NUM
ecletica-285	162	15	complex	complex	NOUN
ecletica-285	162	16	is	be	AUX
ecletica-285	162	17	smaller	small	ADJ
ecletica-285	162	18	than	than	ADP
ecletica-285	162	19	for	for	ADP
ecletica-285	162	20	the	the	DET
ecletica-285	162	21	other	other	ADJ
ecletica-285	162	22	two	two	NUM
ecletica-285	162	23	oxicans	oxican	NOUN
ecletica-285	162	24	.	.	PUNCT
ecletica-285	163	1	table	table	NOUN
ecletica-285	163	2	1	1	NUM
ecletica-285	163	3	resumes	resume	VERB
ecletica-285	163	4	these	these	DET
ecletica-285	163	5	comments	comment	NOUN
ecletica-285	163	6	.	.	PUNCT
ecletica-285	164	1	table	table	NOUN
ecletica-285	164	2	1	1	NUM
ecletica-285	164	3	relation	relation	NOUN
ecletica-285	164	4	among	among	ADP
ecletica-285	164	5	bond	bond	NOUN
ecletica-285	164	6	energy	energy	NOUN
ecletica-285	164	7	,	,	PUNCT
ecletica-285	164	8	nature	nature	NOUN
ecletica-285	164	9	of	of	ADP
ecletica-285	164	10	the	the	DET
ecletica-285	164	11	hydrogen	hydrogen	NOUN
ecletica-285	164	12	bonds	bond	NOUN
ecletica-285	164	13	(	(	PUNCT
ecletica-285	164	14	hb	hb	X
ecletica-285	164	15	)	)	PUNCT
ecletica-285	164	16	between	between	ADP
ecletica-285	164	17	the	the	DET
ecletica-285	164	18	ligands	ligand	NOUN
ecletica-285	164	19	and	and	CCONJ
ecletica-285	164	20	zn	zn	PROPN
ecletica-285	164	21	environment	environment	NOUN
ecletica-285	164	22	of	of	ADP
ecletica-285	164	23	mmp-1	mmp-1	NOUN
ecletica-285	164	24	,	,	PUNCT
ecletica-285	164	25	and	and	CCONJ
ecletica-285	164	26	intensity	intensity	NOUN
ecletica-285	164	27	of	of	ADP
ecletica-285	164	28	inhibition	inhibition	NOUN
ecletica-285	164	29	of	of	ADP
ecletica-285	164	30	enzyme	enzyme	NOUN
ecletica-285	164	31	activity	activity	NOUN
ecletica-285	164	32	.	.	PUNCT
ecletica-285	165	1	the	the	PRON
ecletica-285	165	2	greater	great	ADJ
ecletica-285	165	3	the	the	DET
ecletica-285	165	4	length	length	NOUN
ecletica-285	165	5	of	of	ADP
ecletica-285	165	6	hb	hb	PROPN
ecletica-285	165	7	and	and	CCONJ
ecletica-285	165	8	the	the	PRON
ecletica-285	165	9	more	more	ADV
ecletica-285	165	10	its	its	PRON
ecletica-285	165	11	angle	angle	NOUN
ecletica-285	165	12	differs	differ	VERB
ecletica-285	165	13	from	from	ADP
ecletica-285	165	14	the	the	DET
ecletica-285	165	15	ideal	ideal	ADJ
ecletica-285	165	16	value	value	NOUN
ecletica-285	165	17	of	of	ADP
ecletica-285	165	18	180	180	NUM
ecletica-285	165	19	°	°	NOUN
ecletica-285	165	20	,	,	PUNCT
ecletica-285	165	21	weaker	weak	ADJ
ecletica-285	165	22	it	it	PRON
ecletica-285	165	23	is	be	AUX
ecletica-285	165	24	.	.	PUNCT
ecletica-285	166	1	ligand	ligand	PROPN
ecletica-285	166	2	(	(	PUNCT
ecletica-285	166	3	l	l	NOUN
ecletica-285	166	4	)	)	PUNCT
ecletica-285	166	5	number	number	NOUN
ecletica-285	166	6	of	of	ADP
ecletica-285	166	7	hb	hb	PROPN
ecletica-285	166	8	(	(	PUNCT
ecletica-285	166	9	total	total	ADJ
ecletica-285	166	10	)	)	PUNCT
ecletica-285	166	11	number	number	NOUN
ecletica-285	166	12	of	of	ADP
ecletica-285	166	13	hb	hb	PROPN
ecletica-285	166	14	l	l	PROPN
ecletica-285	166	15	....	....	PROPN
ecletica-285	167	1	o	o	X
ecletica-285	168	1			VERB
ecletica-285	168	2	zn	zn	PROPN
ecletica-285	168	3	length	length	NOUN
ecletica-285	168	4	of	of	ADP
ecletica-285	168	5	hb	hb	PROPN
ecletica-285	168	6	(	(	PUNCT
ecletica-285	168	7	å	å	NOUN
ecletica-285	168	8	)	)	PUNCT
ecletica-285	168	9	angle	angle	NOUN
ecletica-285	168	10	of	of	ADP
ecletica-285	168	11	hb	hb	PROPN
ecletica-285	168	12	(	(	PUNCT
ecletica-285	168	13	degree	degree	NOUN
ecletica-285	168	14	)	)	PUNCT
ecletica-285	168	15	ligand	ligand	NOUN
ecletica-285	168	16	ic50	ic50	PROPN
ecletica-285	168	17	(	(	PUNCT
ecletica-285	168	18	µm	µm	NOUN
ecletica-285	168	19	)	)	PUNCT
ecletica-285	168	20	total	total	ADJ
ecletica-285	168	21	bond	bond	NOUN
ecletica-285	168	22	energy	energy	NOUN
ecletica-285	168	23	(	(	PUNCT
ecletica-285	168	24	hartree	hartree	ADJ
ecletica-285	168	25	)	)	PUNCT
ecletica-285	168	26	piroxicam	piroxicam	NOUN
ecletica-285	168	27	2	2	NUM
ecletica-285	168	28	2	2	NUM
ecletica-285	168	29	2.049	2.049	NUM
ecletica-285	168	30	1.726	1.726	NUM
ecletica-285	168	31	126.5	126.5	NUM
ecletica-285	168	32	°	°	NOUN
ecletica-285	168	33	164.3	164.3	NUM
ecletica-285	168	34	°	°	NOUN
ecletica-285	168	35	63	63	NUM
ecletica-285	168	36	-0.090489	-0.090489	NOUN
ecletica-285	168	37	meloxicam	meloxicam	NOUN
ecletica-285	168	38	2	2	NUM
ecletica-285	168	39	2	2	NUM
ecletica-285	168	40	1.975	1.975	NUM
ecletica-285	168	41	1.687	1.687	NUM
ecletica-285	168	42	123,8	123,8	NUM
ecletica-285	168	43	°	°	NOUN
ecletica-285	168	44	169.5	169.5	NUM
ecletica-285	168	45	°	°	SYM
ecletica-285	168	46	66	66	NUM
ecletica-285	168	47	-0.090757	-0.090757	NOUN
ecletica-285	168	48	tenoxicam	tenoxicam	VERB
ecletica-285	168	49	4	4	NUM
ecletica-285	168	50	1	1	NUM
ecletica-285	168	51	2.219	2.219	NUM
ecletica-285	168	52	121.0	121.0	NUM
ecletica-285	168	53	°	°	NOUN
ecletica-285	168	54	91	91	NUM
ecletica-285	168	55	-0.064924	-0.064924	NOUN
ecletica-285	168	56	alendronate	alendronate	NOUN
ecletica-285	168	57	4	4	NUM
ecletica-285	168	58	0	0	NUM
ecletica-285	168	59	activator	activator	NOUN
ecletica-285	168	60	-0.022507	-0.022507	NOUN
ecletica-285	168	61	concluding	concluding	NOUN
ecletica-285	168	62	,	,	PUNCT
ecletica-285	168	63	for	for	ADP
ecletica-285	168	64	the	the	DET
ecletica-285	168	65	three	three	NUM
ecletica-285	168	66	oxicans	oxican	NOUN
ecletica-285	168	67	,	,	PUNCT
ecletica-285	168	68	the	the	DET
ecletica-285	168	69	more	more	ADV
ecletica-285	168	70	important	important	ADJ
ecletica-285	168	71	groups	group	NOUN
ecletica-285	168	72	for	for	ADP
ecletica-285	168	73	interaction	interaction	NOUN
ecletica-285	168	74	with	with	ADP
ecletica-285	168	75	the	the	DET
ecletica-285	168	76	human	human	ADJ
ecletica-285	168	77	collagenase	collagenase	NOUN
ecletica-285	168	78	are	be	AUX
ecletica-285	168	79	the	the	DET
ecletica-285	168	80	hydroxyl	hydroxyl	NOUN
ecletica-285	168	81	and	and	CCONJ
ecletica-285	168	82	the	the	DET
ecletica-285	168	83	secondary	secondary	ADJ
ecletica-285	168	84	amine	amine	NOUN
ecletica-285	168	85	,	,	PUNCT
ecletica-285	168	86	binding	bind	VERB
ecletica-285	168	87	to	to	ADP
ecletica-285	168	88	the	the	DET
ecletica-285	168	89	heterocyclic	heterocyclic	ADJ
ecletica-285	168	90	ring	ring	NOUN
ecletica-285	168	91	and	and	CCONJ
ecletica-285	168	92	to	to	ADP
ecletica-285	168	93	the	the	DET
ecletica-285	168	94	carbonyl	carbonyl	NOUN
ecletica-285	168	95	,	,	PUNCT
ecletica-285	168	96	respectively	respectively	ADV
ecletica-285	168	97	.	.	PUNCT
ecletica-285	169	1	in	in	ADP
ecletica-285	169	2	the	the	DET
ecletica-285	169	3	three	three	NUM
ecletica-285	169	4	cases	case	NOUN
ecletica-285	169	5	the	the	DET
ecletica-285	169	6	hydroxyl	hydroxyl	NOUN
ecletica-285	169	7	establishes	establish	VERB
ecletica-285	169	8	a	a	DET
ecletica-285	169	9	hydrogen	hydrogen	NOUN
ecletica-285	169	10	bond	bond	NOUN
ecletica-285	169	11	with	with	ADP
ecletica-285	169	12	the	the	DET
ecletica-285	169	13	atom	atom	NOUN
ecletica-285	169	14	of	of	ADP
ecletica-285	169	15	oxygen	oxygen	NOUN
ecletica-285	169	16	linked	link	VERB
ecletica-285	169	17	to	to	ADP
ecletica-285	169	18	catalytic	catalytic	ADJ
ecletica-285	169	19	zinc	zinc	NOUN
ecletica-285	169	20	.	.	PUNCT
ecletica-285	170	1	the	the	DET
ecletica-285	170	2	amine	amine	ADJ
ecletica-285	170	3	forms	form	NOUN
ecletica-285	170	4	a	a	DET
ecletica-285	170	5	second	second	ADJ
ecletica-285	170	6	hydrogen	hydrogen	NOUN
ecletica-285	170	7	bond	bond	NOUN
ecletica-285	170	8	with	with	ADP
ecletica-285	170	9	the	the	DET
ecletica-285	170	10	same	same	ADJ
ecletica-285	170	11	oxygen	oxygen	NOUN
ecletica-285	170	12	for	for	ADP
ecletica-285	170	13	meloxicam	meloxicam	NOUN
ecletica-285	170	14	and	and	CCONJ
ecletica-285	170	15	piroxicam	piroxicam	VERB
ecletica-285	170	16	,	,	PUNCT
ecletica-285	170	17	but	but	CCONJ
ecletica-285	170	18	this	this	PRON
ecletica-285	170	19	does	do	AUX
ecletica-285	170	20	not	not	PART
ecletica-285	170	21	occur	occur	VERB
ecletica-285	170	22	with	with	ADP
ecletica-285	170	23	tenoxicam	tenoxicam	NOUN
ecletica-285	170	24	,	,	PUNCT
ecletica-285	170	25	on	on	ADP
ecletica-285	170	26	account	account	NOUN
ecletica-285	170	27	of	of	ADP
ecletica-285	170	28	the	the	DET
ecletica-285	170	29	inappropriate	inappropriate	ADJ
ecletica-285	170	30	geometry	geometry	NOUN
ecletica-285	170	31	of	of	ADP
ecletica-285	170	32	the	the	DET
ecletica-285	170	33	groups	group	NOUN
ecletica-285	170	34	involved	involve	VERB
ecletica-285	170	35	,	,	PUNCT
ecletica-285	170	36	particularly	particularly	ADV
ecletica-285	170	37	a	a	DET
ecletica-285	170	38	very	very	ADV
ecletica-285	170	39	small	small	ADJ
ecletica-285	170	40	n	n	CCONJ
ecletica-285	170	41	-	-	PUNCT
ecletica-285	170	42	h	h	NOUN
ecletica-285	170	43	-	-	PUNCT
ecletica-285	170	44	o	o	NOUN
ecletica-285	170	45	angle	angle	NOUN
ecletica-285	170	46	(	(	PUNCT
ecletica-285	170	47	86.7	86.7	NUM
ecletica-285	170	48	°	°	NUM
ecletica-285	170	49	)	)	PUNCT
ecletica-285	170	50	.	.	PUNCT
ecletica-285	171	1	this	this	DET
ecletica-285	171	2	fact	fact	NOUN
ecletica-285	171	3	,	,	PUNCT
ecletica-285	171	4	plus	plus	CCONJ
ecletica-285	171	5	the	the	DET
ecletica-285	171	6	o	o	NOUN
ecletica-285	171	7	–	–	PUNCT
ecletica-285	171	8	h	h	NOUN
ecletica-285	171	9	.....	.....	PUNCT
ecletica-285	172	1	o	o	X
ecletica-285	172	2	bond	bond	NOUN
ecletica-285	172	3	weaker	weak	ADJ
ecletica-285	172	4	than	than	ADP
ecletica-285	172	5	the	the	DET
ecletica-285	172	6	analog	analog	ADJ
ecletica-285	172	7	ones	one	NOUN
ecletica-285	172	8	in	in	ADP
ecletica-285	172	9	the	the	DET
ecletica-285	172	10	other	other	ADJ
ecletica-285	172	11	two	two	NUM
ecletica-285	172	12	oxicans	oxican	NOUN
ecletica-285	172	13	,	,	PUNCT
ecletica-285	172	14	result	result	VERB
ecletica-285	172	15	in	in	ADP
ecletica-285	172	16	a	a	DET
ecletica-285	172	17	smaller	small	ADJ
ecletica-285	172	18	inhibiting	inhibit	VERB
ecletica-285	172	19	effect	effect	NOUN
ecletica-285	172	20	of	of	ADP
ecletica-285	172	21	tenoxicam	tenoxicam	NOUN
ecletica-285	172	22	upon	upon	SCONJ
ecletica-285	172	23	the	the	DET
ecletica-285	172	24	human	human	ADJ
ecletica-285	172	25	collagenase	collagenase	NOUN
ecletica-285	172	26	.	.	PUNCT
ecletica-285	173	1	besides	besides	SCONJ
ecletica-285	173	2	the	the	DET
ecletica-285	173	3	adequate	adequate	ADJ
ecletica-285	173	4	geometry	geometry	NOUN
ecletica-285	173	5	,	,	PUNCT
ecletica-285	173	6	electronic	electronic	ADJ
ecletica-285	173	7	requirements	requirement	NOUN
ecletica-285	173	8	must	must	AUX
ecletica-285	173	9	be	be	AUX
ecletica-285	173	10	satisfied	satisfied	ADJ
ecletica-285	173	11	for	for	ADP
ecletica-285	173	12	the	the	DET
ecletica-285	173	13	establishment	establishment	NOUN
ecletica-285	173	14	of	of	ADP
ecletica-285	173	15	a	a	DET
ecletica-285	173	16	hydrogen	hydrogen	NOUN
ecletica-285	173	17	bond	bond	NOUN
ecletica-285	173	18	:	:	PUNCT
ecletica-285	173	19	representing	represent	VERB
ecletica-285	173	20	this	this	PRON
ecletica-285	173	21	by	by	ADP
ecletica-285	173	22	a	a	DET
ecletica-285	173	23	–	–	PUNCT
ecletica-285	173	24	h	h	NOUN
ecletica-285	173	25	.....	.....	PUNCT
ecletica-285	174	1	b	b	X
ecletica-285	174	2	,	,	PUNCT
ecletica-285	174	3	the	the	DET
ecletica-285	174	4	bond	bond	NOUN
ecletica-285	174	5	is	be	AUX
ecletica-285	174	6	stronger	strong	ADJ
ecletica-285	174	7	as	as	ADP
ecletica-285	174	8	more	more	ADV
ecletica-285	174	9	electronegative	electronegative	ADJ
ecletica-285	174	10	is	be	AUX
ecletica-285	174	11	the	the	DET
ecletica-285	174	12	atom	atom	NOUN
ecletica-285	174	13	a	a	PRON
ecletica-285	174	14	and	and	CCONJ
ecletica-285	174	15	better	well	ADJ
ecletica-285	174	16	electron	electron	NOUN
ecletica-285	174	17	donor	donor	NOUN
ecletica-285	174	18	is	be	AUX
ecletica-285	174	19	the	the	DET
ecletica-285	174	20	atom	atom	PROPN
ecletica-285	174	21	b.	b.	PROPN
ecletica-285	175	1	thus	thus	ADV
ecletica-285	175	2	,	,	PUNCT
ecletica-285	175	3	lower	low	ADJ
ecletica-285	175	4	the	the	DET
ecletica-285	175	5	electronic	electronic	ADJ
ecletica-285	175	6	charge	charge	NOUN
ecletica-285	175	7	in	in	ADP
ecletica-285	175	8	a	a	DET
ecletica-285	175	9	(	(	PUNCT
ecletica-285	175	10	less	less	ADV
ecletica-285	175	11	negative	negative	ADJ
ecletica-285	175	12	,	,	PUNCT
ecletica-285	175	13	therefore	therefore	ADV
ecletica-285	175	14	)	)	PUNCT
ecletica-285	175	15	and	and	CCONJ
ecletica-285	175	16	greater	great	ADJ
ecletica-285	175	17	in	in	ADP
ecletica-285	175	18	b	b	NOUN
ecletica-285	175	19	(	(	PUNCT
ecletica-285	175	20	more	more	ADV
ecletica-285	175	21	negative	negative	ADJ
ecletica-285	175	22	)	)	PUNCT
ecletica-285	175	23	,	,	PUNCT
ecletica-285	175	24	better	well	ADJ
ecletica-285	175	25	.	.	PUNCT
ecletica-285	176	1	for	for	ADP
ecletica-285	176	2	the	the	DET
ecletica-285	176	3	oxicans	oxican	NOUN
ecletica-285	176	4	,	,	PUNCT
ecletica-285	176	5	atom	atom	NOUN
ecletica-285	176	6	a	a	PRON
ecletica-285	176	7	is	be	AUX
ecletica-285	176	8	represented	represent	VERB
ecletica-285	176	9	by	by	ADP
ecletica-285	176	10	the	the	DET
ecletica-285	176	11	hydroxyl	hydroxyl	NOUN
ecletica-285	176	12	oxygen	oxygen	NOUN
ecletica-285	176	13	and	and	CCONJ
ecletica-285	176	14	by	by	ADP
ecletica-285	176	15	the	the	DET
ecletica-285	176	16	amine	amine	ADJ
ecletica-285	176	17	nitrogen	nitrogen	NOUN
ecletica-285	176	18	.	.	PUNCT
ecletica-285	177	1	for	for	ADP
ecletica-285	177	2	the	the	DET
ecletica-285	177	3	three	three	NUM
ecletica-285	177	4	oxicans	oxican	NOUN
ecletica-285	177	5	,	,	PUNCT
ecletica-285	177	6	electronic	electronic	ADJ
ecletica-285	177	7	partial	partial	ADJ
ecletica-285	177	8	charge	charge	NOUN
ecletica-285	177	9	on	on	ADP
ecletica-285	177	10	hydroxyl	hydroxyl	NOUN
ecletica-285	177	11	oxygen	oxygen	NOUN
ecletica-285	177	12	varies	vary	VERB
ecletica-285	177	13	very	very	ADV
ecletica-285	177	14	little	little	ADJ
ecletica-285	177	15	(	(	PUNCT
ecletica-285	177	16	fig	fig	NOUN
ecletica-285	177	17	.	.	PUNCT
ecletica-285	178	1	5	5	NUM
ecletica-285	178	2	)	)	PUNCT
ecletica-285	179	1	,	,	PUNCT
ecletica-285	179	2	indicating	indicate	VERB
ecletica-285	179	3	that	that	SCONJ
ecletica-285	179	4	this	this	DET
ecletica-285	179	5	property	property	NOUN
ecletica-285	179	6	is	be	AUX
ecletica-285	179	7	irrelevant	irrelevant	ADJ
ecletica-285	179	8	in	in	ADP
ecletica-285	179	9	differentiating	differentiate	VERB
ecletica-285	179	10	the	the	DET
ecletica-285	179	11	inhibitory	inhibitory	ADJ
ecletica-285	179	12	effect	effect	NOUN
ecletica-285	179	13	,	,	PUNCT
ecletica-285	179	14	here	here	ADV
ecletica-285	179	15	essentially	essentially	ADV
ecletica-285	179	16	dependent	dependent	ADJ
ecletica-285	179	17	on	on	ADP
ecletica-285	179	18	the	the	DET
ecletica-285	179	19	geometry	geometry	NOUN
ecletica-285	179	20	.	.	PUNCT
ecletica-285	180	1	curiously	curiously	ADV
ecletica-285	180	2	,	,	PUNCT
ecletica-285	180	3	the	the	DET
ecletica-285	180	4	positive	positive	ADJ
ecletica-285	180	5	charge	charge	NOUN
ecletica-285	180	6	on	on	ADP
ecletica-285	180	7	the	the	DET
ecletica-285	180	8	hydroxyl	hydroxyl	NOUN
ecletica-285	180	9	hydrogen	hydrogen	NOUN
ecletica-285	180	10	is	be	AUX
ecletica-285	180	11	higher	high	ADJ
ecletica-285	180	12	in	in	ADP
ecletica-285	180	13	tenoxicam	tenoxicam	NOUN
ecletica-285	180	14	,	,	PUNCT
ecletica-285	180	15	which	which	PRON
ecletica-285	180	16	has	have	VERB
ecletica-285	180	17	the	the	DET
ecletica-285	180	18	less	less	ADV
ecletica-285	180	19	favorable	favorable	ADJ
ecletica-285	180	20	geometry	geometry	NOUN
ecletica-285	180	21	,	,	PUNCT
ecletica-285	180	22	resulting	result	VERB
ecletica-285	180	23	in	in	ADP
ecletica-285	180	24	a	a	DET
ecletica-285	180	25	lower	low	ADJ
ecletica-285	180	26	inhibiting	inhibit	VERB
ecletica-285	180	27	effect	effect	NOUN
ecletica-285	180	28	.	.	PUNCT
ecletica-285	181	1	this	this	PRON
ecletica-285	181	2	indicates	indicate	VERB
ecletica-285	181	3	that	that	SCONJ
ecletica-285	181	4	any	any	DET
ecletica-285	181	5	effort	effort	NOUN
ecletica-285	181	6	to	to	PART
ecletica-285	181	7	increase	increase	VERB
ecletica-285	181	8	the	the	DET
ecletica-285	181	9	electron	electron	NOUN
ecletica-285	181	10	density	density	NOUN
ecletica-285	181	11	on	on	ADP
ecletica-285	181	12	the	the	DET
ecletica-285	181	13	hydroxyl	hydroxyl	NOUN
ecletica-285	181	14	hydrogen	hydrogen	NOUN
ecletica-285	181	15	of	of	ADP
ecletica-285	181	16	tenoxicam	tenoxicam	NOUN
ecletica-285	181	17	would	would	AUX
ecletica-285	181	18	be	be	AUX
ecletica-285	181	19	innocuous	innocuous	ADJ
ecletica-285	181	20	to	to	PART
ecletica-285	181	21	intensify	intensify	VERB
ecletica-285	181	22	its	its	PRON
ecletica-285	181	23	inhibitory	inhibitory	ADJ
ecletica-285	181	24	effect	effect	NOUN
ecletica-285	181	25	.	.	PUNCT
ecletica-285	182	1	the	the	DET
ecletica-285	182	2	same	same	ADJ
ecletica-285	182	3	behavior	behavior	NOUN
ecletica-285	182	4	occurs	occur	VERB
ecletica-285	182	5	for	for	ADP
ecletica-285	182	6	the	the	DET
ecletica-285	182	7	amine	amine	ADJ
ecletica-285	182	8	hydrogen	hydrogen	NOUN
ecletica-285	182	9	of	of	ADP
ecletica-285	182	10	the	the	DET
ecletica-285	182	11	oxicans	oxican	NOUN
ecletica-285	182	12	,	,	PUNCT
ecletica-285	182	13	whose	whose	DET
ecletica-285	182	14	partial	partial	ADJ
ecletica-285	182	15	charges	charge	NOUN
ecletica-285	182	16	vary	vary	VERB
ecletica-285	182	17	in	in	ADP
ecletica-285	182	18	the	the	DET
ecletica-285	182	19	same	same	ADJ
ecletica-285	182	20	sense	sense	NOUN
ecletica-285	182	21	.	.	PUNCT
ecletica-285	183	1	ecl	ecl	PROPN
ecletica-285	183	2	.	.	PROPN
ecletica-285	183	3	quím	quím	PROPN
ecletica-285	183	4	.	.	PUNCT
ecletica-285	183	5	,	,	PUNCT
ecletica-285	183	6	são	são	PROPN
ecletica-285	183	7	paulo	paulo	PROPN
ecletica-285	183	8	,	,	PUNCT
ecletica-285	183	9	34(4	34(4	NUM
ecletica-285	183	10	):	):	PUNCT
ecletica-285	183	11	87	87	NUM
ecletica-285	183	12	102	102	NUM
ecletica-285	183	13	,	,	PUNCT
ecletica-285	183	14	200998	200998	NUM
ecletica-285	183	15	artigo	artigo	PROPN
ecletica-285	183	16	article	article	NOUN
ecletica-285	183	17	fig	fig	NOUN
ecletica-285	183	18	.	.	PUNCT
ecletica-285	184	1	5	5	NUM
ecletica-285	184	2	mülliken	mülliken	VERB
ecletica-285	184	3	partial	partial	ADJ
ecletica-285	184	4	charges	charge	NOUN
ecletica-285	184	5	for	for	ADP
ecletica-285	184	6	meloxicam	meloxicam	NOUN
ecletica-285	184	7	,	,	PUNCT
ecletica-285	184	8	piroxicam	piroxicam	VERB
ecletica-285	184	9	and	and	CCONJ
ecletica-285	184	10	tenoxicam	tenoxicam	VERB
ecletica-285	184	11	.	.	PUNCT
ecletica-285	185	1	in	in	ADP
ecletica-285	185	2	conclusion	conclusion	NOUN
ecletica-285	185	3	,	,	PUNCT
ecletica-285	185	4	among	among	ADP
ecletica-285	185	5	the	the	DET
ecletica-285	185	6	essayed	essay	VERB
ecletica-285	185	7	compounds	compound	NOUN
ecletica-285	185	8	,	,	PUNCT
ecletica-285	185	9	only	only	ADV
ecletica-285	185	10	meloxicam	meloxicam	NOUN
ecletica-285	185	11	and	and	CCONJ
ecletica-285	185	12	piroxicam	piroxicam	PROPN
ecletica-285	185	13	may	may	AUX
ecletica-285	185	14	be	be	AUX
ecletica-285	185	15	useful	useful	ADJ
ecletica-285	185	16	as	as	SCONJ
ecletica-285	185	17	leaders	leader	NOUN
ecletica-285	185	18	compounds	compound	VERB
ecletica-285	185	19	for	for	ADP
ecletica-285	185	20	the	the	DET
ecletica-285	185	21	search	search	NOUN
ecletica-285	185	22	of	of	ADP
ecletica-285	185	23	more	more	ADV
ecletica-285	185	24	potent	potent	ADJ
ecletica-285	185	25	collagenase	collagenase	NOUN
ecletica-285	185	26	inhibitors	inhibitor	NOUN
ecletica-285	185	27	.	.	PUNCT
ecletica-285	186	1	their	their	PRON
ecletica-285	186	2	geometry	geometry	NOUN
ecletica-285	186	3	is	be	AUX
ecletica-285	186	4	correct	correct	ADJ
ecletica-285	186	5	and	and	CCONJ
ecletica-285	186	6	a	a	DET
ecletica-285	186	7	stronger	strong	ADJ
ecletica-285	186	8	bond	bond	NOUN
ecletica-285	186	9	with	with	ADP
ecletica-285	186	10	the	the	DET
ecletica-285	186	11	enzyme	enzyme	NOUN
ecletica-285	186	12	may	may	AUX
ecletica-285	186	13	be	be	AUX
ecletica-285	186	14	obtained	obtain	VERB
ecletica-285	186	15	varying	vary	VERB
ecletica-285	186	16	adequately	adequately	ADV
ecletica-285	186	17	the	the	DET
ecletica-285	186	18	electronic	electronic	ADJ
ecletica-285	186	19	densities	density	NOUN
ecletica-285	186	20	.	.	PUNCT
ecletica-285	187	1	this	this	PRON
ecletica-285	187	2	could	could	AUX
ecletica-285	187	3	be	be	AUX
ecletica-285	187	4	achieved	achieve	VERB
ecletica-285	187	5	by	by	ADP
ecletica-285	187	6	appropriate	appropriate	ADJ
ecletica-285	187	7	substitutions	substitution	NOUN
ecletica-285	187	8	in	in	ADP
ecletica-285	187	9	different	different	ADJ
ecletica-285	187	10	groups	group	NOUN
ecletica-285	187	11	of	of	ADP
ecletica-285	187	12	the	the	DET
ecletica-285	187	13	molecules	molecule	NOUN
ecletica-285	187	14	,	,	PUNCT
ecletica-285	187	15	capable	capable	ADJ
ecletica-285	187	16	to	to	PART
ecletica-285	187	17	reduce	reduce	VERB
ecletica-285	187	18	the	the	DET
ecletica-285	187	19	electronic	electronic	ADJ
ecletica-285	187	20	densities	density	NOUN
ecletica-285	187	21	on	on	ADP
ecletica-285	187	22	hydroxyl	hydroxyl	NOUN
ecletica-285	187	23	and	and	CCONJ
ecletica-285	187	24	amine	amine	ADJ
ecletica-285	187	25	hydrogens	hydrogen	NOUN
ecletica-285	187	26	.	.	PUNCT
ecletica-285	188	1	as	as	ADP
ecletica-285	188	2	examples	example	NOUN
ecletica-285	188	3	,	,	PUNCT
ecletica-285	188	4	we	we	PRON
ecletica-285	188	5	calculated	calculate	VERB
ecletica-285	188	6	the	the	DET
ecletica-285	188	7	partial	partial	ADJ
ecletica-285	188	8	charges	charge	NOUN
ecletica-285	188	9	of	of	ADP
ecletica-285	188	10	the	the	DET
ecletica-285	188	11	fluorine	fluorine	NOUN
ecletica-285	188	12	and	and	CCONJ
ecletica-285	188	13	nitro	nitro	NOUN
ecletica-285	188	14	-	-	PUNCT
ecletica-285	188	15	derivatives	derivative	NOUN
ecletica-285	188	16	of	of	ADP
ecletica-285	188	17	meloxicam	meloxicam	NOUN
ecletica-285	188	18	and	and	CCONJ
ecletica-285	188	19	piroxicam	piroxicam	VERB
ecletica-285	188	20	.	.	PUNCT
ecletica-285	189	1	first	first	ADV
ecletica-285	189	2	,	,	PUNCT
ecletica-285	189	3	for	for	ADP
ecletica-285	189	4	meloxicam	meloxicam	NOUN
ecletica-285	189	5	,	,	PUNCT
ecletica-285	189	6	the	the	DET
ecletica-285	189	7	fluorination	fluorination	NOUN
ecletica-285	189	8	of	of	ADP
ecletica-285	189	9	carbon	carbon	NOUN
ecletica-285	189	10	5	5	NUM
ecletica-285	189	11	(	(	PUNCT
ecletica-285	189	12	numeration	numeration	NOUN
ecletica-285	189	13	in	in	ADP
ecletica-285	189	14	fig.4	fig.4	PROPN
ecletica-285	189	15	)	)	PUNCT
ecletica-285	190	1	[	[	X
ecletica-285	190	2	35	35	NUM
ecletica-285	190	3	]	]	PUNCT
ecletica-285	190	4	of	of	ADP
ecletica-285	190	5	the	the	DET
ecletica-285	190	6	aromatic	aromatic	ADJ
ecletica-285	190	7	ring	ring	NOUN
ecletica-285	190	8	increases	increase	VERB
ecletica-285	190	9	the	the	DET
ecletica-285	190	10	hydroxyl	hydroxyl	NOUN
ecletica-285	190	11	h	h	NOUN
ecletica-285	190	12	partial	partial	ADJ
ecletica-285	190	13	charge	charge	NOUN
ecletica-285	190	14	from	from	ADP
ecletica-285	190	15	0.218	0.218	NUM
ecletica-285	190	16	to	to	ADP
ecletica-285	190	17	0.226	0.226	NUM
ecletica-285	190	18	,	,	PUNCT
ecletica-285	190	19	and	and	CCONJ
ecletica-285	190	20	the	the	DET
ecletica-285	190	21	perfluorination	perfluorination	NOUN
ecletica-285	190	22	of	of	ADP
ecletica-285	190	23	the	the	DET
ecletica-285	190	24	ring	ring	NOUN
ecletica-285	190	25	(	(	PUNCT
ecletica-285	190	26	four	four	NUM
ecletica-285	190	27	fluorine	fluorine	NOUN
ecletica-285	190	28	atoms	atom	NOUN
ecletica-285	190	29	)	)	PUNCT
ecletica-285	190	30	increases	increase	VERB
ecletica-285	190	31	this	this	DET
ecletica-285	190	32	charge	charge	NOUN
ecletica-285	190	33	to	to	ADP
ecletica-285	190	34	0.272	0.272	NUM
ecletica-285	190	35	.	.	PUNCT
ecletica-285	191	1	the	the	DET
ecletica-285	191	2	amine	amine	ADJ
ecletica-285	191	3	h	h	NOUN
ecletica-285	191	4	is	be	AUX
ecletica-285	191	5	little	little	ADV
ecletica-285	191	6	affected	affected	ADJ
ecletica-285	191	7	,	,	PUNCT
ecletica-285	191	8	provide	provide	VERB
ecletica-285	191	9	that	that	SCONJ
ecletica-285	191	10	the	the	DET
ecletica-285	191	11	inductive	inductive	ADJ
ecletica-285	191	12	effect	effect	NOUN
ecletica-285	191	13	spreads	spread	VERB
ecletica-285	191	14	little	little	ADJ
ecletica-285	191	15	in	in	ADP
ecletica-285	191	16	the	the	DET
ecletica-285	191	17	carbon	carbon	NOUN
ecletica-285	191	18	chain	chain	NOUN
ecletica-285	191	19	.	.	PUNCT
ecletica-285	192	1	otherwise	otherwise	ADV
ecletica-285	192	2	,	,	PUNCT
ecletica-285	192	3	in	in	ADP
ecletica-285	192	4	the	the	DET
ecletica-285	192	5	case	case	NOUN
ecletica-285	192	6	of	of	ADP
ecletica-285	192	7	piroxicam	piroxicam	NOUN
ecletica-285	192	8	,	,	PUNCT
ecletica-285	192	9	both	both	CCONJ
ecletica-285	192	10	mono	mono	NOUN
ecletica-285	192	11	and	and	CCONJ
ecletica-285	192	12	perfluorination	perfluorination	NOUN
ecletica-285	192	13	have	have	VERB
ecletica-285	192	14	no	no	DET
ecletica-285	192	15	effect	effect	NOUN
ecletica-285	192	16	on	on	ADP
ecletica-285	192	17	the	the	DET
ecletica-285	192	18	hydrogen	hydrogen	NOUN
ecletica-285	192	19	charges	charge	NOUN
ecletica-285	192	20	.	.	PUNCT
ecletica-285	193	1	therefore	therefore	ADV
ecletica-285	193	2	,	,	PUNCT
ecletica-285	193	3	it	it	PRON
ecletica-285	193	4	is	be	AUX
ecletica-285	193	5	probable	probable	ADJ
ecletica-285	193	6	that	that	SCONJ
ecletica-285	193	7	the	the	DET
ecletica-285	193	8	fluorination	fluorination	NOUN
ecletica-285	193	9	redounds	redound	VERB
ecletica-285	193	10	in	in	ADP
ecletica-285	193	11	some	some	DET
ecletica-285	193	12	increase	increase	NOUN
ecletica-285	193	13	in	in	ADP
ecletica-285	193	14	the	the	DET
ecletica-285	193	15	intensity	intensity	NOUN
ecletica-285	193	16	of	of	ADP
ecletica-285	193	17	the	the	DET
ecletica-285	193	18	hydrogen	hydrogen	NOUN
ecletica-285	193	19	bond	bond	NOUN
ecletica-285	193	20	between	between	ADP
ecletica-285	193	21	hydroxyl	hydroxyl	NOUN
ecletica-285	193	22	and	and	CCONJ
ecletica-285	193	23	enzyme	enzyme	NOUN
ecletica-285	193	24	,	,	PUNCT
ecletica-285	193	25	but	but	CCONJ
ecletica-285	193	26	only	only	ADV
ecletica-285	193	27	in	in	ADP
ecletica-285	193	28	the	the	DET
ecletica-285	193	29	case	case	NOUN
ecletica-285	193	30	of	of	ADP
ecletica-285	193	31	meloxicam	meloxicam	NOUN
ecletica-285	193	32	.	.	PUNCT
ecletica-285	194	1	nitration	nitration	NOUN
ecletica-285	194	2	(	(	PUNCT
ecletica-285	194	3	mono	mono	PROPN
ecletica-285	194	4	)	)	PUNCT
ecletica-285	194	5	of	of	ADP
ecletica-285	194	6	the	the	DET
ecletica-285	194	7	aromatic	aromatic	ADJ
ecletica-285	194	8	ring	ring	NOUN
ecletica-285	194	9	may	may	AUX
ecletica-285	194	10	occur	occur	VERB
ecletica-285	194	11	in	in	ADP
ecletica-285	194	12	the	the	DET
ecletica-285	194	13	carbon	carbon	NOUN
ecletica-285	194	14	atoms	atom	NOUN
ecletica-285	194	15	vicinal	vicinal	ADJ
ecletica-285	194	16	and	and	CCONJ
ecletica-285	194	17	not	not	PART
ecletica-285	194	18	vicinal	vicinal	ADJ
ecletica-285	194	19	in	in	ADP
ecletica-285	194	20	relation	relation	NOUN
ecletica-285	194	21	to	to	ADP
ecletica-285	194	22	the	the	DET
ecletica-285	194	23	neighboring	neighboring	NOUN
ecletica-285	194	24	ring	ring	NOUN
ecletica-285	194	25	.	.	PUNCT
ecletica-285	195	1	such	such	ADJ
ecletica-285	195	2	nitration	nitration	NOUN
ecletica-285	195	3	decreases	decrease	VERB
ecletica-285	195	4	the	the	DET
ecletica-285	195	5	electron	electron	NOUN
ecletica-285	195	6	density	density	NOUN
ecletica-285	195	7	on	on	ADP
ecletica-285	195	8	positions	position	NOUN
ecletica-285	195	9	ortho	ortho	PROPN
ecletica-285	195	10	and	and	CCONJ
ecletica-285	195	11	para	para	NOUN
ecletica-285	195	12	regarding	regard	VERB
ecletica-285	195	13	the	the	DET
ecletica-285	195	14	nitro	nitro	NOUN
ecletica-285	195	15	group	group	NOUN
ecletica-285	195	16	,	,	PUNCT
ecletica-285	195	17	with	with	ADP
ecletica-285	195	18	almost	almost	ADV
ecletica-285	195	19	no	no	PRON
ecletica-285	195	20	change	change	NOUN
ecletica-285	195	21	in	in	ADP
ecletica-285	195	22	position	position	NOUN
ecletica-285	195	23	meta	meta	ADJ
ecletica-285	195	24	.	.	PUNCT
ecletica-285	196	1	this	this	DET
ecletica-285	196	2	behavior	behavior	NOUN
ecletica-285	196	3	results	result	VERB
ecletica-285	196	4	from	from	ADP
ecletica-285	196	5	the	the	DET
ecletica-285	196	6	strong	strong	ADJ
ecletica-285	196	7	mesomeric	mesomeric	ADJ
ecletica-285	196	8	effect	effect	NOUN
ecletica-285	196	9	[	[	X
ecletica-285	196	10	36	36	NUM
ecletica-285	196	11	]	]	PUNCT
ecletica-285	196	12	generated	generate	VERB
ecletica-285	196	13	by	by	ADP
ecletica-285	196	14	this	this	DET
ecletica-285	196	15	group	group	NOUN
ecletica-285	196	16	,	,	PUNCT
ecletica-285	196	17	as	as	SCONJ
ecletica-285	196	18	illustrated	illustrate	VERB
ecletica-285	196	19	in	in	ADP
ecletica-285	196	20	the	the	DET
ecletica-285	196	21	diagram	diagram	NOUN
ecletica-285	196	22	below	below	ADV
ecletica-285	196	23	(	(	PUNCT
ecletica-285	196	24	fig	fig	NOUN
ecletica-285	196	25	.	.	PUNCT
ecletica-285	197	1	6	6	NUM
ecletica-285	197	2	)	)	PUNCT
ecletica-285	197	3	.	.	PUNCT
ecletica-285	198	1	+	+	CCONJ
ecletica-285	198	2	etc	etc	X
ecletica-285	198	3	o	o	NOUN
ecletica-285	198	4	o	o	NOUN
ecletica-285	198	5	n	n	CCONJ
ecletica-285	198	6	oo	oo	INTJ
ecletica-285	198	7	n	n	CCONJ
ecletica-285	198	8	oo	oo	INTJ
ecletica-285	198	9	n	n	PROPN
ecletica-285	198	10	+	+	CCONJ
ecletica-285	198	11	+	+	CCONJ
ecletica-285	198	12	+	+	CCONJ
ecletica-285	198	13	--+	--+	ADJ
ecletica-285	198	14	fig	fig	NOUN
ecletica-285	198	15	.	.	PUNCT
ecletica-285	199	1	6	6	NUM
ecletica-285	199	2	mesomeric	mesomeric	ADJ
ecletica-285	199	3	effect	effect	NOUN
ecletica-285	199	4	of	of	ADP
ecletica-285	199	5	nitro	nitro	NOUN
ecletica-285	199	6	group	group	NOUN
ecletica-285	199	7	on	on	ADP
ecletica-285	199	8	the	the	DET
ecletica-285	199	9	benzene	benzene	NOUN
ecletica-285	199	10	ring	ring	NOUN
ecletica-285	199	11	.	.	PUNCT
ecletica-285	200	1	in	in	ADP
ecletica-285	200	2	consequence	consequence	NOUN
ecletica-285	200	3	,	,	PUNCT
ecletica-285	200	4	the	the	DET
ecletica-285	200	5	nitration	nitration	NOUN
ecletica-285	200	6	in	in	ADP
ecletica-285	200	7	carbon	carbon	NOUN
ecletica-285	200	8	5	5	NUM
ecletica-285	200	9	of	of	ADP
ecletica-285	200	10	meloxicam	meloxicam	NOUN
ecletica-285	200	11	and	and	CCONJ
ecletica-285	200	12	piroxicam	piroxicam	VERB
ecletica-285	200	13	causes	cause	VERB
ecletica-285	200	14	great	great	ADJ
ecletica-285	200	15	reduction	reduction	NOUN
ecletica-285	200	16	in	in	ADP
ecletica-285	200	17	the	the	DET
ecletica-285	200	18	electron	electron	NOUN
ecletica-285	200	19	density	density	NOUN
ecletica-285	200	20	of	of	ADP
ecletica-285	200	21	neighbor	neighbor	NOUN
ecletica-285	200	22	carbon	carbon	NOUN
ecletica-285	200	23	,	,	PUNCT
ecletica-285	200	24	while	while	SCONJ
ecletica-285	200	25	the	the	DET
ecletica-285	200	26	nitration	nitration	NOUN
ecletica-285	200	27	in	in	ADP
ecletica-285	200	28	position	position	NOUN
ecletica-285	200	29	6	6	NUM
ecletica-285	200	30	does	do	AUX
ecletica-285	200	31	not	not	PART
ecletica-285	200	32	influence	influence	VERB
ecletica-285	200	33	it	it	PRON
ecletica-285	200	34	.	.	PUNCT
ecletica-285	201	1	in	in	ADP
ecletica-285	201	2	the	the	DET
ecletica-285	201	3	meloxicam	meloxicam	NOUN
ecletica-285	201	4	,	,	PUNCT
ecletica-285	201	5	the	the	DET
ecletica-285	201	6	charge	charge	NOUN
ecletica-285	201	7	on	on	ADP
ecletica-285	201	8	this	this	DET
ecletica-285	201	9	carbon	carbon	NOUN
ecletica-285	201	10	changes	change	NOUN
ecletica-285	201	11	from	from	ADP
ecletica-285	201	12	0.022	0.022	NUM
ecletica-285	201	13	to	to	ADP
ecletica-285	201	14	0.182	0.182	NUM
ecletica-285	201	15	in	in	ADP
ecletica-285	201	16	the	the	DET
ecletica-285	201	17	nitro	nitro	NOUN
ecletica-285	201	18	compound	compound	NOUN
ecletica-285	201	19	in	in	ADP
ecletica-285	201	20	6	6	NUM
ecletica-285	201	21	and	and	CCONJ
ecletica-285	201	22	does	do	AUX
ecletica-285	201	23	not	not	PART
ecletica-285	201	24	change	change	VERB
ecletica-285	201	25	(	(	PUNCT
ecletica-285	201	26	0.020	0.020	NUM
ecletica-285	201	27	)	)	PUNCT
ecletica-285	201	28	in	in	ADP
ecletica-285	201	29	the	the	DET
ecletica-285	201	30	nitro	nitro	NOUN
ecletica-285	201	31	compound	compound	NOUN
ecletica-285	201	32	in	in	ADP
ecletica-285	201	33	7	7	NUM
ecletica-285	201	34	.	.	PUNCT
ecletica-285	202	1	in	in	ADP
ecletica-285	202	2	the	the	DET
ecletica-285	202	3	case	case	NOUN
ecletica-285	202	4	of	of	ADP
ecletica-285	202	5	piroxicam	piroxicam	NOUN
ecletica-285	202	6	,	,	PUNCT
ecletica-285	202	7	in	in	ADP
ecletica-285	202	8	the	the	DET
ecletica-285	202	9	first	first	ADJ
ecletica-285	202	10	case	case	NOUN
ecletica-285	202	11	the	the	DET
ecletica-285	202	12	charge	charge	NOUN
ecletica-285	202	13	goes	go	VERB
ecletica-285	202	14	from	from	ADP
ecletica-285	202	15	0.027	0.027	NUM
ecletica-285	202	16	to	to	ADP
ecletica-285	202	17	0.185	0.185	NUM
ecletica-285	202	18	and	and	CCONJ
ecletica-285	202	19	in	in	ADP
ecletica-285	202	20	the	the	DET
ecletica-285	202	21	second	second	ADJ
ecletica-285	202	22	to	to	ADP
ecletica-285	202	23	0.047	0.047	NUM
ecletica-285	202	24	.	.	PUNCT
ecletica-285	203	1	such	such	ADJ
ecletica-285	203	2	change	change	NOUN
ecletica-285	203	3	in	in	ADP
ecletica-285	203	4	formal	formal	ADJ
ecletica-285	203	5	charge	charge	NOUN
ecletica-285	203	6	in	in	ADP
ecletica-285	203	7	the	the	DET
ecletica-285	203	8	5	5	NUM
ecletica-285	203	9	-	-	PUNCT
ecletica-285	203	10	nitro	nitro	NOUN
ecletica-285	203	11	derivatives	derivative	NOUN
ecletica-285	203	12	also	also	ADV
ecletica-285	203	13	reflects	reflect	VERB
ecletica-285	203	14	on	on	ADP
ecletica-285	203	15	the	the	DET
ecletica-285	203	16	carbon	carbon	NOUN
ecletica-285	203	17	4	4	NUM
ecletica-285	203	18	,	,	PUNCT
ecletica-285	203	19	bound	bind	VERB
ecletica-285	203	20	to	to	ADP
ecletica-285	203	21	the	the	DET
ecletica-285	203	22	hydroxyl	hydroxyl	NOUN
ecletica-285	203	23	group	group	NOUN
ecletica-285	203	24	,	,	PUNCT
ecletica-285	203	25	and	and	CCONJ
ecletica-285	203	26	consequently	consequently	ADV
ecletica-285	203	27	on	on	ADP
ecletica-285	203	28	the	the	DET
ecletica-285	203	29	hydroxyl	hydroxyl	NOUN
ecletica-285	203	30	itself	itself	PRON
ecletica-285	203	31	.	.	PUNCT
ecletica-285	204	1	the	the	DET
ecletica-285	204	2	partial	partial	ADJ
ecletica-285	204	3	charge	charge	NOUN
ecletica-285	204	4	rises	rise	VERB
ecletica-285	204	5	on	on	ADP
ecletica-285	204	6	carbon	carbon	NOUN
ecletica-285	204	7	4	4	NUM
ecletica-285	204	8	in	in	ADP
ecletica-285	204	9	both	both	DET
ecletica-285	204	10	oxicans	oxican	NOUN
ecletica-285	204	11	,	,	PUNCT
ecletica-285	204	12	and	and	CCONJ
ecletica-285	204	13	the	the	DET
ecletica-285	204	14	hydrogen	hydrogen	NOUN
ecletica-285	204	15	of	of	ADP
ecletica-285	204	16	the	the	DET
ecletica-285	204	17	ecl	ecl	PROPN
ecletica-285	204	18	.	.	PROPN
ecletica-285	204	19	quím	quím	PROPN
ecletica-285	204	20	.	.	PUNCT
ecletica-285	205	1	,	,	PUNCT
ecletica-285	205	2	são	são	PROPN
ecletica-285	205	3	paulo	paulo	PROPN
ecletica-285	205	4	,	,	PUNCT
ecletica-285	205	5	34(4	34(4	NUM
ecletica-285	205	6	):	):	PUNCT
ecletica-285	205	7	87	87	NUM
ecletica-285	205	8	102	102	NUM
ecletica-285	205	9	,	,	PUNCT
ecletica-285	205	10	2009	2009	NUM
ecletica-285	205	11	99	99	NUM
ecletica-285	205	12	artigo	artigo	NOUN
ecletica-285	205	13	article	article	NOUN
ecletica-285	205	14	hydroxyl	hydroxyl	PROPN
ecletica-285	205	15	group	group	NOUN
ecletica-285	205	16	becomes	become	VERB
ecletica-285	205	17	more	more	ADV
ecletica-285	205	18	positive	positive	ADJ
ecletica-285	205	19	.	.	PUNCT
ecletica-285	206	1	this	this	PRON
ecletica-285	206	2	is	be	AUX
ecletica-285	206	3	schematized	schematize	VERB
ecletica-285	206	4	in	in	ADP
ecletica-285	206	5	the	the	DET
ecletica-285	206	6	figure	figure	NOUN
ecletica-285	206	7	7	7	NUM
ecletica-285	206	8	.	.	PUNCT
ecletica-285	207	1	n	n	PRON
ecletica-285	208	1	o	o	NOUN
ecletica-285	208	2	o	o	X
ecletica-285	208	3	o	o	NOUN
ecletica-285	208	4	h	h	NOUN
ecletica-285	209	1	+	+	CCONJ
ecletica-285	210	1	+	+	NUM
ecletica-285	210	2	h	h	NOUN
ecletica-285	210	3	o	o	NOUN
ecletica-285	210	4	oo	oo	INTJ
ecletica-285	210	5	n	n	PROPN
ecletica-285	210	6	+	+	CCONJ
ecletica-285	211	1	+	+	CCONJ
ecletica-285	211	2	h	h	NOUN
ecletica-285	211	3	o	o	NOUN
ecletica-285	211	4	oo	oo	INTJ
ecletica-285	211	5	n	n	PROPN
ecletica-285	211	6	+	+	X
ecletica-285	211	7	fig	fig	NOUN
ecletica-285	211	8	.	.	PUNCT
ecletica-285	212	1	7	7	NUM
ecletica-285	212	2	resonance	resonance	NOUN
ecletica-285	212	3	structures	structure	NOUN
ecletica-285	212	4	in	in	ADP
ecletica-285	212	5	nitrated	nitrated	ADJ
ecletica-285	212	6	meloxicam	meloxicam	NOUN
ecletica-285	212	7	and	and	CCONJ
ecletica-285	212	8	piroxicam	piroxicam	VERB
ecletica-285	212	9	.	.	PUNCT
ecletica-285	213	1	greater	great	ADJ
ecletica-285	213	2	extension	extension	NOUN
ecletica-285	213	3	of	of	ADP
ecletica-285	213	4	aromaticity	aromaticity	NOUN
ecletica-285	213	5	of	of	ADP
ecletica-285	213	6	the	the	DET
ecletica-285	213	7	benzene	benzene	NOUN
ecletica-285	213	8	ring	ring	NOUN
ecletica-285	213	9	to	to	ADP
ecletica-285	213	10	the	the	DET
ecletica-285	213	11	alongside	alongside	ADJ
ecletica-285	213	12	ring	ring	NOUN
ecletica-285	213	13	in	in	ADP
ecletica-285	213	14	the	the	DET
ecletica-285	213	15	ortho	ortho	PROPN
ecletica-285	213	16	derivative	derivative	NOUN
ecletica-285	213	17	,	,	PUNCT
ecletica-285	213	18	on	on	ADP
ecletica-285	213	19	account	account	NOUN
ecletica-285	213	20	of	of	ADP
ecletica-285	213	21	electron	electron	NOUN
ecletica-285	213	22	delocalization	delocalization	NOUN
ecletica-285	213	23	extended	extend	VERB
ecletica-285	213	24	to	to	ADP
ecletica-285	213	25	him	he	PRON
ecletica-285	213	26	,	,	PUNCT
ecletica-285	213	27	intensifies	intensify	VERB
ecletica-285	213	28	the	the	DET
ecletica-285	213	29	phenolic	phenolic	ADJ
ecletica-285	213	30	character	character	NOUN
ecletica-285	213	31	of	of	ADP
ecletica-285	213	32	the	the	DET
ecletica-285	213	33	group	group	NOUN
ecletica-285	213	34	oh	oh	INTJ
ecletica-285	213	35	.	.	PUNCT
ecletica-285	214	1	thus	thus	ADV
ecletica-285	214	2	,	,	PUNCT
ecletica-285	214	3	this	this	DET
ecletica-285	214	4	group	group	NOUN
ecletica-285	214	5	becomes	become	VERB
ecletica-285	214	6	more	more	ADV
ecletica-285	214	7	acidic	acidic	ADJ
ecletica-285	214	8	and	and	CCONJ
ecletica-285	214	9	the	the	DET
ecletica-285	214	10	h	h	NOUN
ecletica-285	214	11	more	more	ADV
ecletica-285	214	12	likely	likely	ADJ
ecletica-285	214	13	to	to	PART
ecletica-285	214	14	form	form	VERB
ecletica-285	214	15	a	a	DET
ecletica-285	214	16	hydrogen	hydrogen	NOUN
ecletica-285	214	17	bond	bond	NOUN
ecletica-285	214	18	with	with	ADP
ecletica-285	214	19	an	an	DET
ecletica-285	214	20	electron	electron	NOUN
ecletica-285	214	21	donor	donor	NOUN
ecletica-285	214	22	center	center	NOUN
ecletica-285	214	23	,	,	PUNCT
ecletica-285	214	24	as	as	SCONJ
ecletica-285	214	25	the	the	DET
ecletica-285	214	26	oxygen	oxygen	NOUN
ecletica-285	214	27	bond	bond	NOUN
ecletica-285	214	28	to	to	ADP
ecletica-285	214	29	mmp-1	mmp-1	X
ecletica-285	214	30	catalytic	catalytic	ADJ
ecletica-285	214	31	zn	zn	PROPN
ecletica-285	214	32	.	.	PUNCT
ecletica-285	215	1	a	a	DET
ecletica-285	215	2	stronger	strong	ADJ
ecletica-285	215	3	hydrogen	hydrogen	NOUN
ecletica-285	215	4	bond	bond	NOUN
ecletica-285	215	5	should	should	AUX
ecletica-285	215	6	result	result	VERB
ecletica-285	215	7	in	in	ADP
ecletica-285	215	8	stronger	strong	ADJ
ecletica-285	215	9	enzyme	enzyme	NOUN
ecletica-285	215	10	inhibition	inhibition	NOUN
ecletica-285	215	11	.	.	PUNCT
ecletica-285	216	1	therefore	therefore	ADV
ecletica-285	216	2	,	,	PUNCT
ecletica-285	216	3	the	the	DET
ecletica-285	216	4	6	6	NUM
ecletica-285	216	5	-	-	PUNCT
ecletica-285	216	6	nitro	nitro	NOUN
ecletica-285	216	7	-	-	PUNCT
ecletica-285	216	8	derivatives	derivative	NOUN
ecletica-285	216	9	of	of	ADP
ecletica-285	216	10	meloxicam	meloxicam	NOUN
ecletica-285	216	11	and	and	CCONJ
ecletica-285	216	12	piroxicam	piroxicam	PROPN
ecletica-285	216	13	could	could	AUX
ecletica-285	216	14	be	be	AUX
ecletica-285	216	15	promising	promise	VERB
ecletica-285	216	16	candidates	candidate	NOUN
ecletica-285	216	17	to	to	ADP
ecletica-285	216	18	inhibitors	inhibitor	NOUN
ecletica-285	216	19	of	of	ADP
ecletica-285	216	20	human	human	ADJ
ecletica-285	216	21	connective	connective	ADJ
ecletica-285	216	22	tissue	tissue	NOUN
ecletica-285	216	23	collagenase	collagenase	NOUN
ecletica-285	216	24	.	.	PUNCT
ecletica-285	217	1	thermodynamics	thermodynamic	NOUN
ecletica-285	217	2	properties	property	NOUN
ecletica-285	217	3	let	let	VERB
ecletica-285	217	4	us	we	PRON
ecletica-285	217	5	discuss	discuss	VERB
ecletica-285	217	6	now	now	ADV
ecletica-285	217	7	the	the	DET
ecletica-285	217	8	effect	effect	NOUN
ecletica-285	217	9	of	of	ADP
ecletica-285	217	10	the	the	DET
ecletica-285	217	11	complexation	complexation	NOUN
ecletica-285	217	12	with	with	ADP
ecletica-285	217	13	ligands	ligand	NOUN
ecletica-285	217	14	on	on	ADP
ecletica-285	217	15	the	the	DET
ecletica-285	217	16	two	two	NUM
ecletica-285	217	17	components	component	NOUN
ecletica-285	217	18	of	of	ADP
ecletica-285	217	19	the	the	DET
ecletica-285	217	20	enzymatic	enzymatic	ADJ
ecletica-285	217	21	entropy	entropy	NOUN
ecletica-285	217	22	.	.	PUNCT
ecletica-285	218	1	first	first	ADV
ecletica-285	218	2	,	,	PUNCT
ecletica-285	218	3	consider	consider	VERB
ecletica-285	218	4	the	the	DET
ecletica-285	218	5	effect	effect	NOUN
ecletica-285	218	6	on	on	ADP
ecletica-285	218	7	the	the	DET
ecletica-285	218	8	entropy	entropy	NOUN
ecletica-285	218	9	of	of	ADP
ecletica-285	218	10	hydration	hydration	NOUN
ecletica-285	218	11	of	of	ADP
ecletica-285	218	12	the	the	DET
ecletica-285	218	13	enzyme	enzyme	NOUN
ecletica-285	218	14	.	.	PUNCT
ecletica-285	219	1	as	as	SCONJ
ecletica-285	219	2	already	already	ADV
ecletica-285	219	3	discussed	discuss	VERB
ecletica-285	219	4	,	,	PUNCT
ecletica-285	219	5	this	this	PRON
ecletica-285	219	6	is	be	AUX
ecletica-285	219	7	increased	increase	VERB
ecletica-285	219	8	by	by	ADP
ecletica-285	219	9	disarray	disarray	NOUN
ecletica-285	219	10	of	of	ADP
ecletica-285	219	11	water	water	NOUN
ecletica-285	219	12	molecules	molecule	NOUN
ecletica-285	219	13	and	and	CCONJ
ecletica-285	219	14	their	their	PRON
ecletica-285	219	15	exclusion	exclusion	NOUN
ecletica-285	219	16	along	along	ADP
ecletica-285	219	17	the	the	DET
ecletica-285	219	18	surface	surface	NOUN
ecletica-285	219	19	that	that	PRON
ecletica-285	219	20	interacts	interact	VERB
ecletica-285	219	21	with	with	ADP
ecletica-285	219	22	the	the	DET
ecletica-285	219	23	ligand	ligand	NOUN
ecletica-285	219	24	.	.	PUNCT
ecletica-285	220	1	by	by	ADP
ecletica-285	220	2	hypothesis	hypothesis	NOUN
ecletica-285	220	3	,	,	PUNCT
ecletica-285	220	4	this	this	DET
ecletica-285	220	5	area	area	NOUN
ecletica-285	220	6	corresponds	correspond	VERB
ecletica-285	220	7	to	to	ADP
ecletica-285	220	8	half	half	NOUN
ecletica-285	220	9	of	of	ADP
ecletica-285	220	10	the	the	DET
ecletica-285	220	11	surface	surface	NOUN
ecletica-285	220	12	area	area	NOUN
ecletica-285	220	13	of	of	ADP
ecletica-285	220	14	ligand	ligand	ADJ
ecletica-285	220	15	molecule	molecule	NOUN
ecletica-285	220	16	.	.	PUNCT
ecletica-285	221	1	as	as	SCONJ
ecletica-285	221	2	seen	see	VERB
ecletica-285	221	3	in	in	ADP
ecletica-285	221	4	table	table	NOUN
ecletica-285	221	5	2	2	NUM
ecletica-285	221	6	,	,	PUNCT
ecletica-285	221	7	the	the	DET
ecletica-285	221	8	ratio	ratio	NOUN
ecletica-285	221	9	between	between	ADP
ecletica-285	221	10	the	the	DET
ecletica-285	221	11	area	area	NOUN
ecletica-285	221	12	of	of	ADP
ecletica-285	221	13	the	the	DET
ecletica-285	221	14	surface	surface	NOUN
ecletica-285	221	15	of	of	ADP
ecletica-285	221	16	the	the	DET
ecletica-285	221	17	enzyme	enzyme	NOUN
ecletica-285	221	18	that	that	PRON
ecletica-285	221	19	interacts	interact	VERB
ecletica-285	221	20	with	with	ADP
ecletica-285	221	21	the	the	DET
ecletica-285	221	22	ligand	ligand	NOUN
ecletica-285	221	23	and	and	CCONJ
ecletica-285	221	24	the	the	DET
ecletica-285	221	25	total	total	ADJ
ecletica-285	221	26	area	area	NOUN
ecletica-285	221	27	of	of	ADP
ecletica-285	221	28	the	the	DET
ecletica-285	221	29	enzyme	enzyme	NOUN
ecletica-285	221	30	is	be	AUX
ecletica-285	221	31	small	small	ADJ
ecletica-285	221	32	,	,	PUNCT
ecletica-285	221	33	about	about	ADV
ecletica-285	221	34	3	3	NUM
ecletica-285	221	35	per	per	ADP
ecletica-285	221	36	cent	cent	NOUN
ecletica-285	221	37	,	,	PUNCT
ecletica-285	221	38	and	and	CCONJ
ecletica-285	221	39	does	do	AUX
ecletica-285	221	40	not	not	PART
ecletica-285	221	41	vary	vary	VERB
ecletica-285	221	42	significantly	significantly	ADV
ecletica-285	221	43	for	for	ADP
ecletica-285	221	44	the	the	DET
ecletica-285	221	45	three	three	NUM
ecletica-285	221	46	oxicans	oxican	NOUN
ecletica-285	221	47	.	.	PUNCT
ecletica-285	222	1	therefore	therefore	ADV
ecletica-285	222	2	,	,	PUNCT
ecletica-285	222	3	the	the	DET
ecletica-285	222	4	stabilizing	stabilize	VERB
ecletica-285	222	5	effect	effect	NOUN
ecletica-285	222	6	of	of	ADP
ecletica-285	222	7	the	the	DET
ecletica-285	222	8	ligand	ligand	NOUN
ecletica-285	222	9	on	on	ADP
ecletica-285	222	10	the	the	DET
ecletica-285	222	11	entropy	entropy	NOUN
ecletica-285	222	12	of	of	ADP
ecletica-285	222	13	hydration	hydration	NOUN
ecletica-285	222	14	is	be	AUX
ecletica-285	222	15	small	small	ADJ
ecletica-285	222	16	.	.	PUNCT
ecletica-285	223	1	furthermore	furthermore	ADV
ecletica-285	223	2	,	,	PUNCT
ecletica-285	223	3	the	the	DET
ecletica-285	223	4	differences	difference	NOUN
ecletica-285	223	5	among	among	ADP
ecletica-285	223	6	the	the	DET
ecletica-285	223	7	areas	area	NOUN
ecletica-285	223	8	of	of	ADP
ecletica-285	223	9	water	water	NOUN
ecletica-285	223	10	exclusion	exclusion	NOUN
ecletica-285	223	11	caused	cause	VERB
ecletica-285	223	12	by	by	ADP
ecletica-285	223	13	the	the	DET
ecletica-285	223	14	different	different	ADJ
ecletica-285	223	15	oxicans	oxican	NOUN
ecletica-285	223	16	are	be	AUX
ecletica-285	223	17	negligible	negligible	ADJ
ecletica-285	223	18	,	,	PUNCT
ecletica-285	223	19	indicating	indicate	VERB
ecletica-285	223	20	that	that	SCONJ
ecletica-285	223	21	this	this	DET
ecletica-285	223	22	effect	effect	NOUN
ecletica-285	223	23	is	be	AUX
ecletica-285	223	24	irrelevant	irrelevant	ADJ
ecletica-285	223	25	to	to	PART
ecletica-285	223	26	explain	explain	VERB
ecletica-285	223	27	the	the	DET
ecletica-285	223	28	difference	difference	NOUN
ecletica-285	223	29	between	between	ADP
ecletica-285	223	30	the	the	DET
ecletica-285	223	31	activity	activity	NOUN
ecletica-285	223	32	of	of	ADP
ecletica-285	223	33	tenoxicam	tenoxicam	NOUN
ecletica-285	223	34	and	and	CCONJ
ecletica-285	223	35	the	the	DET
ecletica-285	223	36	other	other	ADJ
ecletica-285	223	37	two	two	NUM
ecletica-285	223	38	oxicans	oxican	NOUN
ecletica-285	223	39	.	.	PUNCT
ecletica-285	224	1	table	table	NOUN
ecletica-285	224	2	2	2	NUM
ecletica-285	224	3	surface	surface	NOUN
ecletica-285	224	4	area	area	NOUN
ecletica-285	224	5	of	of	ADP
ecletica-285	224	6	human	human	ADJ
ecletica-285	224	7	collagenase	collagenase	NOUN
ecletica-285	224	8	and	and	CCONJ
ecletica-285	224	9	oxicans	oxican	NOUN
ecletica-285	224	10	,	,	PUNCT
ecletica-285	224	11	and	and	CCONJ
ecletica-285	224	12	ratio	ratio	NOUN
ecletica-285	224	13	between	between	ADP
ecletica-285	224	14	the	the	DET
ecletica-285	224	15	half	half	NOUN
ecletica-285	224	16	of	of	ADP
ecletica-285	224	17	ligand	ligand	NOUN
ecletica-285	224	18	surface	surface	NOUN
ecletica-285	224	19	area	area	NOUN
ecletica-285	224	20	and	and	CCONJ
ecletica-285	224	21	the	the	DET
ecletica-285	224	22	area	area	NOUN
ecletica-285	224	23	of	of	ADP
ecletica-285	224	24	the	the	DET
ecletica-285	224	25	enzyme	enzyme	NOUN
ecletica-285	224	26	.	.	PUNCT
ecletica-285	225	1	molecule	molecule	NOUN
ecletica-285	225	2	surface	surface	NOUN
ecletica-285	225	3	area	area	NOUN
ecletica-285	225	4	(	(	PUNCT
ecletica-285	225	5	å2	å2	PROPN
ecletica-285	225	6	)	)	PUNCT
ecletica-285	225	7	half	half	ADJ
ecletica-285	225	8	surface	surface	NOUN
ecletica-285	225	9	area	area	NOUN
ecletica-285	225	10	(	(	PUNCT
ecletica-285	225	11	å2	å2	PROPN
ecletica-285	225	12	)	)	PUNCT
ecletica-285	225	13	ratio	ratio	NOUN
ecletica-285	225	14	½	½	PROPN
ecletica-285	225	15	surface	surface	PROPN
ecletica-285	225	16	area	area	PROPN
ecletica-285	225	17	lig	lig	PROPN
ecletica-285	225	18	.	.	PUNCT
ecletica-285	225	19	/	/	SYM
ecletica-285	225	20	surface	surface	NOUN
ecletica-285	225	21	area	area	NOUN
ecletica-285	225	22	mmp1	mmp1	PROPN
ecletica-285	225	23	human	human	PROPN
ecletica-285	225	24	collagenase	collagenase	NOUN
ecletica-285	225	25	8619,19	8619,19	PROPN
ecletica-285	225	26	–	–	PUNCT
ecletica-285	225	27	–	–	PUNCT
ecletica-285	225	28	piroxicam	piroxicam	VERB
ecletica-285	225	29	510,89	510,89	ADJ
ecletica-285	225	30	255,45	255,45	NOUN
ecletica-285	225	31	0,030	0,030	NUM
ecletica-285	226	1	meloxicam	meloxicam	NOUN
ecletica-285	226	2	535,02	535,02	NUM
ecletica-285	226	3	267,51	267,51	NUM
ecletica-285	226	4	0,031	0,031	NUM
ecletica-285	226	5	tenoxicam	tenoxicam	NOUN
ecletica-285	226	6	504,92	504,92	NOUN
ecletica-285	226	7	252,46	252,46	NOUN
ecletica-285	226	8	0,029	0,029	NUM
ecletica-285	226	9	molecule	molecule	NOUN
ecletica-285	226	10	total	total	ADJ
ecletica-285	226	11	energy	energy	NOUN
ecletica-285	226	12	of	of	ADP
ecletica-285	226	13	the	the	DET
ecletica-285	226	14	optimized	optimize	VERB
ecletica-285	226	15	structure	structure	NOUN
ecletica-285	226	16	(	(	PUNCT
ecletica-285	226	17	kcal/	kcal/	NUM
ecletica-285	226	18	mol	mol	NOUN
ecletica-285	226	19	)	)	PUNCT
ecletica-285	226	20	total	total	ADJ
ecletica-285	226	21	energy	energy	NOUN
ecletica-285	226	22	after	after	ADP
ecletica-285	226	23	heating	heat	VERB
ecletica-285	226	24	0	0	NUM
ecletica-285	226	25	to	to	ADP
ecletica-285	226	26	300	300	NUM
ecletica-285	226	27	k	k	NOUN
ecletica-285	226	28	(	(	PUNCT
ecletica-285	226	29	kcal	kcal	PROPN
ecletica-285	226	30	/	/	SYM
ecletica-285	226	31	mol	mol	NOUN
ecletica-285	226	32	)	)	PUNCT
ecletica-285	226	33	entropy	entropy	NOUN
ecletica-285	226	34	(	(	PUNCT
ecletica-285	226	35	s	s	NOUN
ecletica-285	226	36	)	)	PUNCT
ecletica-285	226	37	(	(	PUNCT
ecletica-285	226	38	kcal	kcal	PROPN
ecletica-285	226	39	/	/	SYM
ecletica-285	226	40	mol.k	mol.k	PROPN
ecletica-285	226	41	)	)	PUNCT
ecletica-285	226	42	sum	sum	NOUN
ecletica-285	226	43	of	of	ADP
ecletica-285	226	44	entropies	entropy	NOUN
ecletica-285	226	45	of	of	ADP
ecletica-285	226	46	enzyme	enzyme	NOUN
ecletica-285	226	47	and	and	CCONJ
ecletica-285	226	48	free	free	ADJ
ecletica-285	226	49	ligands	ligand	NOUN
ecletica-285	226	50	difference	difference	NOUN
ecletica-285	226	51	(	(	PUNCT
ecletica-285	226	52	ssum	ssum	PROPN
ecletica-285	226	53	scomplex	scomplex	PROPN
ecletica-285	226	54	)	)	PUNCT
ecletica-285	226	55	human	human	ADJ
ecletica-285	226	56	collagenase	collagenase	NOUN
ecletica-285	226	57	9859,48	9859,48	NUM
ecletica-285	226	58	-7037,12	-7037,12	PROPN
ecletica-285	226	59	11,16	11,16	PROPN
ecletica-285	226	60			PROPN
ecletica-285	226	61			PROPN
ecletica-285	226	62	piroxicam	piroxicam	PROPN
ecletica-285	226	63	37,898	37,898	NUM
ecletica-285	226	64	89,278	89,278	NUM
ecletica-285	226	65	0,171	0,171	NUM
ecletica-285	226	66			PROPN
ecletica-285	226	67			PROPN
ecletica-285	226	68	meloxicam	meloxicam	NOUN
ecletica-285	226	69	45,152	45,152	NUM
ecletica-285	226	70	92,412	92,412	NUM
ecletica-285	226	71	0,158	0,158	NUM
ecletica-285	226	72			VERB
ecletica-285	226	73			PROPN
ecletica-285	226	74	tenoxicam	tenoxicam	NOUN
ecletica-285	226	75	57,229	57,229	NUM
ecletica-285	226	76	98,187	98,187	NUM
ecletica-285	226	77	0,137	0,137	NUM
ecletica-285	226	78			ADJ
ecletica-285	226	79			PROPN
ecletica-285	226	80	collagenase	collagenase	NOUN
ecletica-285	226	81	+	+	CCONJ
ecletica-285	227	1	piroxicam	piroxicam	ADJ
ecletica-285	227	2	-9473,34	-9473,34	INTJ
ecletica-285	228	1	-7471,95	-7471,95	PROPN
ecletica-285	228	2	10,66	10,66	PROPN
ecletica-285	228	3	11,33	11,33	NUM
ecletica-285	228	4	0,67	0,67	X
ecletica-285	228	5	collagenase	collagenase	PROPN
ecletica-285	228	6	+	+	CCONJ
ecletica-285	228	7	meloxicam	meloxicam	PROPN
ecletica-285	229	1	-9501,59	-9501,59	INTJ
ecletica-285	230	1	-6862,33	-6862,33	NOUN
ecletica-285	230	2	10,91	10,91	NUM
ecletica-285	230	3	11,32	11,32	PROPN
ecletica-285	230	4	0,41	0,41	PROPN
ecletica-285	230	5	collagenase	collagenase	NOUN
ecletica-285	230	6	+	+	CCONJ
ecletica-285	230	7	tenoxicam	tenoxicam	NOUN
ecletica-285	230	8	-9464,15	-9464,15	NOUN
ecletica-285	230	9	-6931,24	-6931,24	NOUN
ecletica-285	230	10	10,98	10,98	NUM
ecletica-285	230	11	11,30	11,30	NOUN
ecletica-285	230	12	0,32	0,32	VERB
ecletica-285	231	1	in	in	ADP
ecletica-285	231	2	conclusion	conclusion	NOUN
ecletica-285	231	3	,	,	PUNCT
ecletica-285	231	4	the	the	DET
ecletica-285	231	5	entropic	entropic	ADJ
ecletica-285	231	6	effect	effect	NOUN
ecletica-285	231	7	seems	seem	VERB
ecletica-285	231	8	to	to	PART
ecletica-285	231	9	be	be	AUX
ecletica-285	231	10	irrelevant	irrelevant	ADJ
ecletica-285	231	11	in	in	ADP
ecletica-285	231	12	the	the	DET
ecletica-285	231	13	interpretation	interpretation	NOUN
ecletica-285	231	14	of	of	ADP
ecletica-285	231	15	inhibitory	inhibitory	ADJ
ecletica-285	231	16	activity	activity	NOUN
ecletica-285	231	17	of	of	ADP
ecletica-285	231	18	the	the	DET
ecletica-285	231	19	ligands	ligand	NOUN
ecletica-285	231	20	.	.	PUNCT
ecletica-285	232	1	thus	thus	ADV
ecletica-285	232	2	,	,	PUNCT
ecletica-285	232	3	the	the	DET
ecletica-285	232	4	inhibition	inhibition	NOUN
ecletica-285	232	5	of	of	ADP
ecletica-285	232	6	human	human	ADJ
ecletica-285	232	7	collagenase	collagenase	NOUN
ecletica-285	232	8	by	by	ADP
ecletica-285	232	9	the	the	DET
ecletica-285	232	10	oxicans	oxicans	PROPN
ecletica-285	232	11	is	be	AUX
ecletica-285	232	12	better	well	ADV
ecletica-285	232	13	justified	justify	VERB
ecletica-285	232	14	by	by	ADP
ecletica-285	232	15	structurally	structurally	ADV
ecletica-285	232	16	specific	specific	ADJ
ecletica-285	232	17	effects	effect	NOUN
ecletica-285	232	18	,	,	PUNCT
ecletica-285	232	19	dependent	dependent	ADJ
ecletica-285	232	20	on	on	ADP
ecletica-285	232	21	their	their	PRON
ecletica-285	232	22	structure	structure	NOUN
ecletica-285	232	23	and	and	CCONJ
ecletica-285	232	24	charge	charge	VERB
ecletica-285	232	25	the	the	DET
ecletica-285	232	26	effect	effect	NOUN
ecletica-285	232	27	of	of	ADP
ecletica-285	232	28	complexation	complexation	NOUN
ecletica-285	232	29	on	on	ADP
ecletica-285	232	30	the	the	DET
ecletica-285	232	31	conformational	conformational	ADJ
ecletica-285	232	32	entropy	entropy	NOUN
ecletica-285	232	33	of	of	ADP
ecletica-285	232	34	the	the	DET
ecletica-285	232	35	collagenase	collagenase	NOUN
ecletica-285	232	36	will	will	AUX
ecletica-285	232	37	be	be	AUX
ecletica-285	232	38	now	now	ADV
ecletica-285	232	39	analyzed	analyze	VERB
ecletica-285	232	40	.	.	PUNCT
ecletica-285	233	1	the	the	DET
ecletica-285	233	2	results	result	NOUN
ecletica-285	233	3	of	of	ADP
ecletica-285	233	4	calculations	calculation	NOUN
ecletica-285	233	5	are	be	AUX
ecletica-285	233	6	summarized	summarize	VERB
ecletica-285	233	7	in	in	ADP
ecletica-285	233	8	table	table	NOUN
ecletica-285	233	9	3	3	NUM
ecletica-285	233	10	.	.	PUNCT
ecletica-285	234	1	we	we	PRON
ecletica-285	234	2	observe	observe	VERB
ecletica-285	234	3	that	that	SCONJ
ecletica-285	234	4	the	the	DET
ecletica-285	234	5	complexation	complexation	NOUN
ecletica-285	234	6	decreases	decrease	VERB
ecletica-285	234	7	a	a	DET
ecletica-285	234	8	little	little	ADJ
ecletica-285	234	9	(	(	PUNCT
ecletica-285	234	10	<	<	X
ecletica-285	234	11	6	6	NUM
ecletica-285	234	12	%	%	NOUN
ecletica-285	234	13	)	)	PUNCT
ecletica-285	234	14	the	the	DET
ecletica-285	234	15	conformational	conformational	ADJ
ecletica-285	234	16	entropy	entropy	NOUN
ecletica-285	234	17	of	of	ADP
ecletica-285	234	18	the	the	DET
ecletica-285	234	19	enzyme	enzyme	NOUN
ecletica-285	234	20	.	.	PUNCT
ecletica-285	235	1	the	the	DET
ecletica-285	235	2	small	small	ADJ
ecletica-285	235	3	decline	decline	NOUN
ecletica-285	235	4	of	of	ADP
ecletica-285	235	5	entropy	entropy	NOUN
ecletica-285	235	6	resulting	result	VERB
ecletica-285	235	7	from	from	ADP
ecletica-285	235	8	this	this	DET
ecletica-285	235	9	interaction	interaction	NOUN
ecletica-285	235	10	indicates	indicate	VERB
ecletica-285	235	11	an	an	DET
ecletica-285	235	12	increase	increase	NOUN
ecletica-285	235	13	in	in	ADP
ecletica-285	235	14	the	the	DET
ecletica-285	235	15	rigidity	rigidity	NOUN
ecletica-285	235	16	of	of	ADP
ecletica-285	235	17	lateral	lateral	ADJ
ecletica-285	235	18	chains	chain	NOUN
ecletica-285	235	19	of	of	ADP
ecletica-285	235	20	some	some	DET
ecletica-285	235	21	amino	amino	NOUN
ecletica-285	235	22	acid	acid	NOUN
ecletica-285	235	23	residues	residue	NOUN
ecletica-285	235	24	of	of	ADP
ecletica-285	235	25	the	the	DET
ecletica-285	235	26	collagenase	collagenase	NOUN
ecletica-285	235	27	,	,	PUNCT
ecletica-285	235	28	due	due	ADP
ecletica-285	235	29	to	to	ADP
ecletica-285	235	30	the	the	DET
ecletica-285	235	31	binding	binding	NOUN
ecletica-285	235	32	with	with	ADP
ecletica-285	235	33	the	the	DET
ecletica-285	235	34	ligands	ligand	NOUN
ecletica-285	235	35	.	.	PUNCT
ecletica-285	236	1	however	however	ADV
ecletica-285	236	2	,	,	PUNCT
ecletica-285	236	3	the	the	DET
ecletica-285	236	4	comparative	comparative	ADJ
ecletica-285	236	5	figures	figure	NOUN
ecletica-285	236	6	between	between	ADP
ecletica-285	236	7	the	the	DET
ecletica-285	236	8	oxicans	oxican	NOUN
ecletica-285	236	9	do	do	AUX
ecletica-285	236	10	not	not	PART
ecletica-285	236	11	justify	justify	VERB
ecletica-285	236	12	the	the	DET
ecletica-285	236	13	observed	observe	VERB
ecletica-285	236	14	differences	difference	NOUN
ecletica-285	236	15	on	on	ADP
ecletica-285	236	16	the	the	DET
ecletica-285	236	17	enzyme	enzyme	NOUN
ecletica-285	236	18	activity	activity	NOUN
ecletica-285	236	19	,	,	PUNCT
ecletica-285	236	20	once	once	SCONJ
ecletica-285	236	21	the	the	DET
ecletica-285	236	22	decrease	decrease	NOUN
ecletica-285	236	23	of	of	ADP
ecletica-285	236	24	the	the	DET
ecletica-285	236	25	entropy	entropy	NOUN
ecletica-285	236	26	follows	follow	VERB
ecletica-285	236	27	the	the	DET
ecletica-285	236	28	same	same	ADJ
ecletica-285	236	29	order	order	NOUN
ecletica-285	236	30	of	of	ADP
ecletica-285	236	31	the	the	DET
ecletica-285	236	32	increase	increase	NOUN
ecletica-285	236	33	in	in	ADP
ecletica-285	236	34	the	the	DET
ecletica-285	236	35	inhibiting	inhibit	VERB
ecletica-285	236	36	activity	activity	NOUN
ecletica-285	236	37	and	and	CCONJ
ecletica-285	236	38	not	not	PART
ecletica-285	236	39	the	the	DET
ecletica-285	236	40	inverse	inverse	NOUN
ecletica-285	236	41	,	,	PUNCT
ecletica-285	236	42	as	as	SCONJ
ecletica-285	236	43	expected	expect	VERB
ecletica-285	236	44	.	.	PUNCT
ecletica-285	237	1	ecl	ecl	PROPN
ecletica-285	237	2	.	.	PROPN
ecletica-285	237	3	quím	quím	PROPN
ecletica-285	237	4	.	.	PUNCT
ecletica-285	237	5	,	,	PUNCT
ecletica-285	237	6	são	são	PROPN
ecletica-285	237	7	paulo	paulo	PROPN
ecletica-285	237	8	,	,	PUNCT
ecletica-285	237	9	34(4	34(4	NUM
ecletica-285	237	10	):	):	PUNCT
ecletica-285	237	11	87	87	NUM
ecletica-285	237	12	102	102	NUM
ecletica-285	237	13	,	,	PUNCT
ecletica-285	237	14	2009100	2009100	NUM
ecletica-285	237	15	artigo	artigo	NOUN
ecletica-285	237	16	article	article	NOUN
ecletica-285	237	17	table	table	VERB
ecletica-285	237	18	3	3	NUM
ecletica-285	237	19	calculation	calculation	NOUN
ecletica-285	237	20	of	of	ADP
ecletica-285	237	21	collagenase	collagenase	PROPN
ecletica-285	237	22	conformational	conformational	ADJ
ecletica-285	237	23	entropy	entropy	NOUN
ecletica-285	237	24	and	and	CCONJ
ecletica-285	237	25	their	their	PRON
ecletica-285	237	26	change	change	NOUN
ecletica-285	237	27	during	during	ADP
ecletica-285	237	28	complexation	complexation	NOUN
ecletica-285	237	29	.	.	PUNCT
ecletica-285	238	1	molecule	molecule	NOUN
ecletica-285	238	2	surface	surface	NOUN
ecletica-285	238	3	area	area	NOUN
ecletica-285	238	4	(	(	PUNCT
ecletica-285	238	5	å2	å2	PROPN
ecletica-285	238	6	)	)	PUNCT
ecletica-285	238	7	half	half	ADJ
ecletica-285	238	8	surface	surface	NOUN
ecletica-285	238	9	area	area	NOUN
ecletica-285	238	10	(	(	PUNCT
ecletica-285	238	11	å2	å2	PROPN
ecletica-285	238	12	)	)	PUNCT
ecletica-285	238	13	ratio	ratio	NOUN
ecletica-285	238	14	½	½	PROPN
ecletica-285	238	15	surface	surface	PROPN
ecletica-285	238	16	area	area	PROPN
ecletica-285	238	17	lig	lig	PROPN
ecletica-285	238	18	.	.	PUNCT
ecletica-285	238	19	/	/	SYM
ecletica-285	238	20	surface	surface	NOUN
ecletica-285	238	21	area	area	NOUN
ecletica-285	238	22	mmp1	mmp1	PROPN
ecletica-285	238	23	human	human	PROPN
ecletica-285	238	24	collagenase	collagenase	NOUN
ecletica-285	238	25	8619,19	8619,19	PROPN
ecletica-285	238	26	–	–	PUNCT
ecletica-285	238	27	–	–	PUNCT
ecletica-285	238	28	piroxicam	piroxicam	VERB
ecletica-285	238	29	510,89	510,89	ADJ
ecletica-285	238	30	255,45	255,45	NOUN
ecletica-285	238	31	0,030	0,030	NUM
ecletica-285	239	1	meloxicam	meloxicam	NOUN
ecletica-285	239	2	535,02	535,02	NUM
ecletica-285	239	3	267,51	267,51	NUM
ecletica-285	239	4	0,031	0,031	NUM
ecletica-285	239	5	tenoxicam	tenoxicam	NOUN
ecletica-285	239	6	504,92	504,92	NOUN
ecletica-285	239	7	252,46	252,46	NOUN
ecletica-285	239	8	0,029	0,029	NUM
ecletica-285	239	9	molecule	molecule	NOUN
ecletica-285	239	10	total	total	ADJ
ecletica-285	239	11	energy	energy	NOUN
ecletica-285	239	12	of	of	ADP
ecletica-285	239	13	the	the	DET
ecletica-285	239	14	optimized	optimize	VERB
ecletica-285	239	15	structure	structure	NOUN
ecletica-285	239	16	(	(	PUNCT
ecletica-285	239	17	kcal/	kcal/	NUM
ecletica-285	239	18	mol	mol	NOUN
ecletica-285	239	19	)	)	PUNCT
ecletica-285	239	20	total	total	ADJ
ecletica-285	239	21	energy	energy	NOUN
ecletica-285	239	22	after	after	ADP
ecletica-285	239	23	heating	heat	VERB
ecletica-285	239	24	0	0	NUM
ecletica-285	239	25	to	to	ADP
ecletica-285	239	26	300	300	NUM
ecletica-285	239	27	k	k	NOUN
ecletica-285	239	28	(	(	PUNCT
ecletica-285	239	29	kcal	kcal	PROPN
ecletica-285	239	30	/	/	SYM
ecletica-285	239	31	mol	mol	NOUN
ecletica-285	239	32	)	)	PUNCT
ecletica-285	239	33	entropy	entropy	NOUN
ecletica-285	239	34	(	(	PUNCT
ecletica-285	239	35	s	s	NOUN
ecletica-285	239	36	)	)	PUNCT
ecletica-285	239	37	(	(	PUNCT
ecletica-285	239	38	kcal	kcal	PROPN
ecletica-285	239	39	/	/	SYM
ecletica-285	239	40	mol.k	mol.k	PROPN
ecletica-285	239	41	)	)	PUNCT
ecletica-285	239	42	sum	sum	NOUN
ecletica-285	239	43	of	of	ADP
ecletica-285	239	44	entropies	entropy	NOUN
ecletica-285	239	45	of	of	ADP
ecletica-285	239	46	enzyme	enzyme	NOUN
ecletica-285	239	47	and	and	CCONJ
ecletica-285	239	48	free	free	ADJ
ecletica-285	239	49	ligands	ligand	NOUN
ecletica-285	239	50	difference	difference	NOUN
ecletica-285	239	51	(	(	PUNCT
ecletica-285	239	52	ssum	ssum	PROPN
ecletica-285	239	53	scomplex	scomplex	PROPN
ecletica-285	239	54	)	)	PUNCT
ecletica-285	239	55	human	human	ADJ
ecletica-285	239	56	collagenase	collagenase	NOUN
ecletica-285	239	57	9859,48	9859,48	NUM
ecletica-285	239	58	-7037,12	-7037,12	PROPN
ecletica-285	239	59	11,16	11,16	PROPN
ecletica-285	239	60			PROPN
ecletica-285	239	61			PROPN
ecletica-285	239	62	piroxicam	piroxicam	PROPN
ecletica-285	239	63	37,898	37,898	NUM
ecletica-285	239	64	89,278	89,278	NUM
ecletica-285	239	65	0,171	0,171	NUM
ecletica-285	239	66			PROPN
ecletica-285	239	67			PROPN
ecletica-285	239	68	meloxicam	meloxicam	NOUN
ecletica-285	239	69	45,152	45,152	NUM
ecletica-285	239	70	92,412	92,412	NUM
ecletica-285	239	71	0,158	0,158	NUM
ecletica-285	239	72			VERB
ecletica-285	239	73			PROPN
ecletica-285	239	74	tenoxicam	tenoxicam	NOUN
ecletica-285	239	75	57,229	57,229	NUM
ecletica-285	239	76	98,187	98,187	NUM
ecletica-285	239	77	0,137	0,137	NUM
ecletica-285	239	78			ADJ
ecletica-285	239	79			PROPN
ecletica-285	239	80	collagenase	collagenase	NOUN
ecletica-285	239	81	+	+	CCONJ
ecletica-285	240	1	piroxicam	piroxicam	ADJ
ecletica-285	240	2	-9473,34	-9473,34	INTJ
ecletica-285	241	1	-7471,95	-7471,95	PROPN
ecletica-285	241	2	10,66	10,66	PROPN
ecletica-285	241	3	11,33	11,33	NUM
ecletica-285	241	4	0,67	0,67	X
ecletica-285	241	5	collagenase	collagenase	PROPN
ecletica-285	241	6	+	+	CCONJ
ecletica-285	241	7	meloxicam	meloxicam	PROPN
ecletica-285	242	1	-9501,59	-9501,59	INTJ
ecletica-285	243	1	-6862,33	-6862,33	NOUN
ecletica-285	243	2	10,91	10,91	NUM
ecletica-285	243	3	11,32	11,32	PROPN
ecletica-285	243	4	0,41	0,41	PROPN
ecletica-285	243	5	collagenase	collagenase	NOUN
ecletica-285	243	6	+	+	CCONJ
ecletica-285	243	7	tenoxicam	tenoxicam	NOUN
ecletica-285	243	8	-9464,15	-9464,15	NOUN
ecletica-285	243	9	-6931,24	-6931,24	NOUN
ecletica-285	243	10	10,98	10,98	NUM
ecletica-285	243	11	11,30	11,30	NOUN
ecletica-285	243	12	0,32	0,32	VERB
ecletica-285	244	1	in	in	ADP
ecletica-285	244	2	conclusion	conclusion	NOUN
ecletica-285	244	3	,	,	PUNCT
ecletica-285	244	4	the	the	DET
ecletica-285	244	5	entropic	entropic	ADJ
ecletica-285	244	6	effect	effect	NOUN
ecletica-285	244	7	seems	seem	VERB
ecletica-285	244	8	to	to	PART
ecletica-285	244	9	be	be	AUX
ecletica-285	244	10	irrelevant	irrelevant	ADJ
ecletica-285	244	11	in	in	ADP
ecletica-285	244	12	the	the	DET
ecletica-285	244	13	interpretation	interpretation	NOUN
ecletica-285	244	14	of	of	ADP
ecletica-285	244	15	inhibitory	inhibitory	ADJ
ecletica-285	244	16	activity	activity	NOUN
ecletica-285	244	17	of	of	ADP
ecletica-285	244	18	the	the	DET
ecletica-285	244	19	ligands	ligand	NOUN
ecletica-285	244	20	.	.	PUNCT
ecletica-285	245	1	thus	thus	ADV
ecletica-285	245	2	,	,	PUNCT
ecletica-285	245	3	the	the	DET
ecletica-285	245	4	inhibition	inhibition	NOUN
ecletica-285	245	5	of	of	ADP
ecletica-285	245	6	human	human	ADJ
ecletica-285	245	7	collagenase	collagenase	NOUN
ecletica-285	245	8	by	by	ADP
ecletica-285	245	9	the	the	DET
ecletica-285	245	10	oxicans	oxicans	PROPN
ecletica-285	245	11	is	be	AUX
ecletica-285	245	12	better	well	ADV
ecletica-285	245	13	justified	justify	VERB
ecletica-285	245	14	by	by	ADP
ecletica-285	245	15	structurally	structurally	ADV
ecletica-285	245	16	specific	specific	ADJ
ecletica-285	245	17	effects	effect	NOUN
ecletica-285	245	18	,	,	PUNCT
ecletica-285	245	19	dependent	dependent	ADJ
ecletica-285	245	20	on	on	ADP
ecletica-285	245	21	their	their	PRON
ecletica-285	245	22	structure	structure	NOUN
ecletica-285	245	23	and	and	CCONJ
ecletica-285	245	24	charge	charge	NOUN
ecletica-285	245	25	in	in	ADP
ecletica-285	245	26	conclusion	conclusion	NOUN
ecletica-285	245	27	,	,	PUNCT
ecletica-285	245	28	the	the	DET
ecletica-285	245	29	entropic	entropic	ADJ
ecletica-285	245	30	effect	effect	NOUN
ecletica-285	245	31	seems	seem	VERB
ecletica-285	245	32	to	to	PART
ecletica-285	245	33	be	be	AUX
ecletica-285	245	34	irrelevant	irrelevant	ADJ
ecletica-285	245	35	in	in	ADP
ecletica-285	245	36	the	the	DET
ecletica-285	245	37	interpretation	interpretation	NOUN
ecletica-285	245	38	of	of	ADP
ecletica-285	245	39	inhibitory	inhibitory	ADJ
ecletica-285	245	40	activity	activity	NOUN
ecletica-285	245	41	of	of	ADP
ecletica-285	245	42	the	the	DET
ecletica-285	245	43	ligands	ligand	NOUN
ecletica-285	245	44	.	.	PUNCT
ecletica-285	246	1	thus	thus	ADV
ecletica-285	246	2	,	,	PUNCT
ecletica-285	246	3	the	the	DET
ecletica-285	246	4	inhibition	inhibition	NOUN
ecletica-285	246	5	of	of	ADP
ecletica-285	246	6	human	human	ADJ
ecletica-285	246	7	collagenase	collagenase	NOUN
ecletica-285	246	8	by	by	ADP
ecletica-285	246	9	the	the	DET
ecletica-285	246	10	oxicans	oxicans	PROPN
ecletica-285	246	11	is	be	AUX
ecletica-285	246	12	better	well	ADV
ecletica-285	246	13	justified	justify	VERB
ecletica-285	246	14	by	by	ADP
ecletica-285	246	15	structurally	structurally	ADV
ecletica-285	246	16	specific	specific	ADJ
ecletica-285	246	17	effects	effect	NOUN
ecletica-285	246	18	,	,	PUNCT
ecletica-285	246	19	dependent	dependent	ADJ
ecletica-285	246	20	on	on	ADP
ecletica-285	246	21	their	their	PRON
ecletica-285	246	22	structure	structure	NOUN
ecletica-285	246	23	and	and	CCONJ
ecletica-285	246	24	charge	charge	NOUN
ecletica-285	246	25	distribution	distribution	NOUN
ecletica-285	246	26	,	,	PUNCT
ecletica-285	246	27	and	and	CCONJ
ecletica-285	246	28	not	not	PART
ecletica-285	246	29	by	by	ADP
ecletica-285	246	30	the	the	DET
ecletica-285	246	31	structurally	structurally	ADV
ecletica-285	246	32	nonspecific	nonspecific	ADJ
ecletica-285	246	33	ones	one	NOUN
ecletica-285	246	34	,	,	PUNCT
ecletica-285	246	35	as	as	ADP
ecletica-285	246	36	the	the	DET
ecletica-285	246	37	case	case	NOUN
ecletica-285	246	38	of	of	ADP
ecletica-285	246	39	the	the	DET
ecletica-285	246	40	entropy	entropy	NOUN
ecletica-285	246	41	.	.	PUNCT
ecletica-285	247	1	this	this	PRON
ecletica-285	247	2	is	be	AUX
ecletica-285	247	3	a	a	DET
ecletica-285	247	4	desirable	desirable	ADJ
ecletica-285	247	5	outcome	outcome	NOUN
ecletica-285	247	6	:	:	PUNCT
ecletica-285	247	7	since	since	SCONJ
ecletica-285	247	8	there	there	PRON
ecletica-285	247	9	is	be	VERB
ecletica-285	247	10	a	a	DET
ecletica-285	247	11	series	series	NOUN
ecletica-285	247	12	of	of	ADP
ecletica-285	247	13	metalloproteinases	metalloproteinase	NOUN
ecletica-285	247	14	in	in	ADP
ecletica-285	247	15	the	the	DET
ecletica-285	247	16	connective	connective	ADJ
ecletica-285	247	17	matrix	matrix	NOUN
ecletica-285	247	18	,	,	PUNCT
ecletica-285	247	19	all	all	PRON
ecletica-285	247	20	of	of	ADP
ecletica-285	247	21	them	they	PRON
ecletica-285	247	22	very	very	ADV
ecletica-285	247	23	similar	similar	ADJ
ecletica-285	247	24	in	in	ADP
ecletica-285	247	25	structure	structure	NOUN
ecletica-285	247	26	,	,	PUNCT
ecletica-285	247	27	but	but	CCONJ
ecletica-285	247	28	with	with	ADP
ecletica-285	247	29	diverse	diverse	ADJ
ecletica-285	247	30	participation	participation	NOUN
ecletica-285	247	31	in	in	ADP
ecletica-285	247	32	different	different	ADJ
ecletica-285	247	33	pathologies	pathology	NOUN
ecletica-285	247	34	,	,	PUNCT
ecletica-285	247	35	the	the	DET
ecletica-285	247	36	selectivity	selectivity	NOUN
ecletica-285	247	37	of	of	ADP
ecletica-285	247	38	the	the	DET
ecletica-285	247	39	inhibitor	inhibitor	NOUN
ecletica-285	247	40	is	be	AUX
ecletica-285	247	41	very	very	ADV
ecletica-285	247	42	important	important	ADJ
ecletica-285	247	43	.	.	PUNCT
ecletica-285	248	1	this	this	DET
ecletica-285	248	2	selectivity	selectivity	NOUN
ecletica-285	248	3	can	can	AUX
ecletica-285	248	4	only	only	ADV
ecletica-285	248	5	be	be	AUX
ecletica-285	248	6	achieved	achieve	VERB
ecletica-285	248	7	through	through	ADP
ecletica-285	248	8	structurally	structurally	ADV
ecletica-285	248	9	specific	specific	ADJ
ecletica-285	248	10	effects	effect	NOUN
ecletica-285	248	11	,	,	PUNCT
ecletica-285	248	12	strictly	strictly	ADV
ecletica-285	248	13	dependent	dependent	ADJ
ecletica-285	248	14	on	on	ADP
ecletica-285	248	15	the	the	DET
ecletica-285	248	16	geometry	geometry	NOUN
ecletica-285	248	17	and	and	CCONJ
ecletica-285	248	18	electronic	electronic	ADJ
ecletica-285	248	19	properties	property	NOUN
ecletica-285	248	20	of	of	ADP
ecletica-285	248	21	the	the	DET
ecletica-285	248	22	molecule	molecule	NOUN
ecletica-285	248	23	.	.	PUNCT
ecletica-285	249	1	acknowledgements	acknowledgement	NOUN
ecletica-285	249	2	we	we	PRON
ecletica-285	249	3	thank	thank	VERB
ecletica-285	249	4	the	the	DET
ecletica-285	249	5	fundação	fundação	PROPN
ecletica-285	249	6	de	de	X
ecletica-285	249	7	amparo	amparo	PROPN
ecletica-285	249	8	à	à	X
ecletica-285	249	9	pesquisa	pesquisa	PROPN
ecletica-285	249	10	do	do	AUX
ecletica-285	249	11	estado	estado	PROPN
ecletica-285	249	12	de	de	PROPN
ecletica-285	249	13	são	são	PROPN
ecletica-285	249	14	paulo	paulo	PROPN
ecletica-285	249	15	(	(	PUNCT
ecletica-285	249	16	fapesp	fapesp	NOUN
ecletica-285	249	17	)	)	PUNCT
ecletica-285	249	18	for	for	ADP
ecletica-285	249	19	the	the	DET
ecletica-285	249	20	financial	financial	ADJ
ecletica-285	249	21	support	support	NOUN
ecletica-285	249	22	(	(	PUNCT
ecletica-285	249	23	proc	proc	NOUN
ecletica-285	249	24	.	.	PUNCT
ecletica-285	250	1	no	no	DET
ecletica-285	250	2	00/11285	00/11285	NUM
ecletica-285	250	3	-	-	SYM
ecletica-285	250	4	6	6	NUM
ecletica-285	250	5	)	)	PUNCT
ecletica-285	250	6	.	.	PUNCT
ecletica-285	251	1	ecl	ecl	PROPN
ecletica-285	251	2	.	.	PROPN
ecletica-285	251	3	quím	quím	PROPN
ecletica-285	251	4	.	.	PUNCT
ecletica-285	251	5	,	,	PUNCT
ecletica-285	251	6	são	são	PROPN
ecletica-285	251	7	paulo	paulo	PROPN
ecletica-285	251	8	,	,	PUNCT
ecletica-285	251	9	34(4	34(4	NUM
ecletica-285	251	10	):	):	PUNCT
ecletica-285	251	11	87	87	NUM
ecletica-285	251	12	102	102	NUM
ecletica-285	251	13	,	,	PUNCT
ecletica-285	251	14	2009	2009	NUM
ecletica-285	251	15	101	101	NUM
ecletica-285	251	16	artigo	artigo	PROPN
ecletica-285	251	17	article	article	NOUN
ecletica-285	251	18	resumo	resumo	NOUN
ecletica-285	251	19	:	:	PUNCT
ecletica-285	251	20	diferentes	diferentes	PROPN
ecletica-285	251	21	substâncias	substâncias	PROPN
ecletica-285	251	22	utilizadas	utilizadas	PROPN
ecletica-285	251	23	como	como	PROPN
ecletica-285	251	24	fármacos	fármacos	PROPN
ecletica-285	251	25	foram	foram	PROPN
ecletica-285	251	26	ensaiadas	ensaiadas	PROPN
ecletica-285	251	27	como	como	PROPN
ecletica-285	251	28	inibidores	inibidores	PROPN
ecletica-285	251	29	da	da	PROPN
ecletica-285	251	30	colagenase	colagenase	PROPN
ecletica-285	251	31	intersticial	intersticial	PROPN
ecletica-285	251	32	humana	humana	PROPN
ecletica-285	251	33	,	,	PUNCT
ecletica-285	251	34	também	também	PROPN
ecletica-285	251	35	conhecida	conhecida	PROPN
ecletica-285	251	36	como	como	PROPN
ecletica-285	251	37	metaloprotease	metaloprotease	PROPN
ecletica-285	251	38	1	1	NUM
ecletica-285	251	39	da	da	PROPN
ecletica-285	251	40	matriz	matriz	X
ecletica-285	251	41	conjuntiva	conjuntiva	PROPN
ecletica-285	251	42	e	e	PROPN
ecletica-285	251	43	pela	pela	PROPN
ecletica-285	251	44	sigla	sigla	PROPN
ecletica-285	252	1	em	em	PRON
ecletica-285	252	2	inglês	inglê	VERB
ecletica-285	252	3	mmp-1	mmp-1	NOUN
ecletica-285	252	4	.	.	PUNCT
ecletica-285	253	1	o	o	PROPN
ecletica-285	253	2	estudo	estudo	PROPN
ecletica-285	253	3	foi	foi	PROPN
ecletica-285	253	4	de	de	X
ecletica-285	253	5	natureza	natureza	PROPN
ecletica-285	253	6	experimental	experimental	PROPN
ecletica-285	253	7	e	e	PROPN
ecletica-285	253	8	também	também	PROPN
ecletica-285	253	9	de	de	PROPN
ecletica-285	253	10	simulação	simulação	PROPN
ecletica-285	253	11	computacional	computacional	PROPN
ecletica-285	253	12	.	.	PUNCT
ecletica-285	254	1	a	a	DET
ecletica-285	254	2	atividade	atividade	PROPN
ecletica-285	254	3	da	da	PROPN
ecletica-285	254	4	colagenase	colagenase	PROPN
ecletica-285	254	5	foi	foi	PROPN
ecletica-285	254	6	quantificada	quantificada	NOUN
ecletica-285	254	7	fluorimetricamente	fluorimetricamente	PROPN
ecletica-285	254	8	,	,	PUNCT
ecletica-285	254	9	pela	pela	PROPN
ecletica-285	254	10	reação	reação	PROPN
ecletica-285	254	11	com	com	PROPN
ecletica-285	254	12	um	um	INTJ
ecletica-285	254	13	substrato	substrato	PROPN
ecletica-285	254	14	sintético	sintético	NOUN
ecletica-285	254	15	fluorescente	fluorescente	PROPN
ecletica-285	254	16	,	,	PUNCT
ecletica-285	254	17	cuja	cuja	PROPN
ecletica-285	254	18	emissão	emissão	PROPN
ecletica-285	254	19	se	se	PROPN
ecletica-285	254	20	altera	altera	PROPN
ecletica-285	254	21	após	apó	VERB
ecletica-285	254	22	a	a	DET
ecletica-285	254	23	hidrólise	hidrólise	NOUN
ecletica-285	254	24	.	.	PUNCT
ecletica-285	255	1	a	a	DET
ecletica-285	255	2	interação	interação	ADJ
ecletica-285	255	3	colagenase	colagenase	PROPN
ecletica-285	255	4	-	-	PUNCT
ecletica-285	255	5	inibidor	inibidor	NOUN
ecletica-285	255	6	foi	foi	PROPN
ecletica-285	255	7	analisada	analisada	PROPN
ecletica-285	255	8	teoricamente	teoricamente	PROPN
ecletica-285	255	9	,	,	PUNCT
ecletica-285	255	10	mediante	mediante	PROPN
ecletica-285	255	11	cálculos	cálculo	NOUN
ecletica-285	255	12	de	de	PROPN
ecletica-285	255	13	docking	docking	NOUN
ecletica-285	255	14	.	.	PUNCT
ecletica-285	256	1	três	três	PROPN
ecletica-285	256	2	das	das	PROPN
ecletica-285	256	3	quatro	quatro	PROPN
ecletica-285	256	4	substâncias	substâncias	PROPN
ecletica-285	256	5	testadas	testadas	PROPN
ecletica-285	256	6	apresentaram	apresentaram	PROPN
ecletica-285	256	7	atividade	atividade	PROPN
ecletica-285	256	8	inibidora	inibidora	PROPN
ecletica-285	256	9	moderada	moderada	PROPN
ecletica-285	256	10	sobre	sobre	PROPN
ecletica-285	256	11	a	a	DET
ecletica-285	256	12	colagenase	colagenase	PROPN
ecletica-285	256	13	humana	humana	PROPN
ecletica-285	256	14	.	.	PUNCT
ecletica-285	257	1	palavras	palavras	PROPN
ecletica-285	257	2	-	-	PUNCT
ecletica-285	257	3	chave	chave	NOUN
ecletica-285	257	4	:	:	PUNCT
ecletica-285	257	5	colagenase	colagenase	NOUN
ecletica-285	257	6	,	,	PUNCT
ecletica-285	257	7	mmp-1	mmp-1	ADP
ecletica-285	257	8	,	,	PUNCT
ecletica-285	257	9	metaloproteases	metaloprotease	VERB
ecletica-285	257	10	humanas	humana	NOUN
ecletica-285	257	11	,	,	PUNCT
ecletica-285	257	12	inibidores	inibidore	NOUN
ecletica-285	257	13	,	,	PUNCT
ecletica-285	257	14	ancoragem	ancoragem	PROPN
ecletica-285	257	15	.	.	PUNCT
ecletica-285	258	1	references	reference	NOUN
ecletica-285	258	2	[	[	X
ecletica-285	259	1	1	1	NUM
ecletica-285	259	2	]	]	X
ecletica-285	259	3	g.j.p	g.j.p	NOUN
ecletica-285	259	4	.	.	PUNCT
ecletica-285	259	5	murphy	murphy	PROPN
ecletica-285	259	6	,	,	PUNCT
ecletica-285	259	7	g.	g.	PROPN
ecletica-285	259	8	murphy	murphy	PROPN
ecletica-285	259	9	,	,	PUNCT
ecletica-285	259	10	j.j	j.j	PROPN
ecletica-285	259	11	.	.	PROPN
ecletica-285	259	12	reinolds	reinolds	PROPN
ecletica-285	259	13	,	,	PUNCT
ecletica-285	259	14	febs	febs	VERB
ecletica-285	259	15	289	289	NUM
ecletica-285	259	16	(	(	PUNCT
ecletica-285	259	17	1991	1991	NUM
ecletica-285	259	18	)	)	PUNCT
ecletica-285	259	19	4	4	NUM
ecletica-285	259	20	.	.	PUNCT
ecletica-285	260	1	[	[	X
ecletica-285	260	2	2	2	NUM
ecletica-285	260	3	]	]	PUNCT
ecletica-285	260	4	browner	browner	ADV
ecletica-285	260	5	,	,	PUNCT
ecletica-285	260	6	m.f	m.f	PROPN
ecletica-285	260	7	.	.	PROPN
ecletica-285	260	8	;	;	PUNCT
ecletica-285	260	9	smith	smith	PROPN
ecletica-285	260	10	,	,	PUNCT
ecletica-285	260	11	w.w	w.w	PROPN
ecletica-285	260	12	.	.	PROPN
ecletica-285	260	13	;	;	PUNCT
ecletica-285	260	14	castelhano	castelhano	PROPN
ecletica-285	260	15	,	,	PUNCT
ecletica-285	260	16	a.l	a.l	PROPN
ecletica-285	260	17	.	.	PROPN
ecletica-285	260	18	biochemistry	biochemistry	PROPN
ecletica-285	260	19	34	34	NUM
ecletica-285	260	20	(	(	PUNCT
ecletica-285	260	21	1995	1995	NUM
ecletica-285	260	22	)	)	PUNCT
ecletica-285	260	23	6602	6602	NUM
ecletica-285	260	24	.	.	PUNCT
ecletica-285	261	1	[	[	X
ecletica-285	261	2	3	3	X
ecletica-285	261	3	]	]	X
ecletica-285	261	4	woessner	woessner	PROPN
ecletica-285	261	5	jr	jr	PROPN
ecletica-285	261	6	,	,	PUNCT
ecletica-285	261	7	j.f	j.f	PROPN
ecletica-285	261	8	.	.	PROPN
ecletica-285	261	9	faseb	faseb	PROPN
ecletica-285	261	10	5	5	NUM
ecletica-285	261	11	(	(	PUNCT
ecletica-285	261	12	1991	1991	NUM
ecletica-285	261	13	)	)	PUNCT
ecletica-285	261	14	2145	2145	NUM
ecletica-285	261	15	.	.	PUNCT
ecletica-285	262	1	[	[	X
ecletica-285	262	2	4	4	NUM
ecletica-285	262	3	]	]	X
ecletica-285	262	4	vallee	vallee	PROPN
ecletica-285	262	5	,	,	PUNCT
ecletica-285	262	6	b.l	b.l	PROPN
ecletica-285	262	7	.	.	PROPN
ecletica-285	262	8	;	;	PUNCT
ecletica-285	262	9	auld	auld	X
ecletica-285	262	10	,	,	PUNCT
ecletica-285	262	11	d.s	d.s	PROPN
ecletica-285	262	12	.	.	PROPN
ecletica-285	262	13	biochemistry	biochemistry	PROPN
ecletica-285	262	14	29	29	NUM
ecletica-285	262	15	(	(	PUNCT
ecletica-285	262	16	1990	1990	NUM
ecletica-285	262	17	)	)	PUNCT
ecletica-285	262	18	5647	5647	NUM
ecletica-285	262	19	.	.	PUNCT
ecletica-285	263	1	[	[	X
ecletica-285	263	2	5	5	NUM
ecletica-285	263	3	]	]	PUNCT
ecletica-285	263	4	salowe	salowe	PROPN
ecletica-285	263	5	,	,	PUNCT
ecletica-285	263	6	s.p	s.p	PROPN
ecletica-285	263	7	.	.	PROPN
ecletica-285	263	8	;	;	PUNCT
ecletica-285	263	9	marcy	marcy	PROPN
ecletica-285	263	10	,	,	PUNCT
ecletica-285	263	11	a.i	a.i	PROPN
ecletica-285	263	12	.	.	PROPN
ecletica-285	263	13	;	;	PUNCT
ecletica-285	263	14	cuca	cuca	PROPN
ecletica-285	263	15	,	,	PUNCT
ecletica-285	263	16	g.c	g.c	PROPN
ecletica-285	263	17	.	.	PROPN
ecletica-285	263	18	;	;	PUNCT
ecletica-285	263	19	smith	smith	PROPN
ecletica-285	263	20	,	,	PUNCT
ecletica-285	263	21	c.k	c.k	PROPN
ecletica-285	263	22	.	.	PROPN
ecletica-285	263	23	;	;	PUNCT
ecletica-285	263	24	kopka	kopka	PROPN
ecletica-285	263	25	,	,	PUNCT
ecletica-285	263	26	i.e.	i.e.	X
ecletica-285	263	27	;	;	PUNCT
ecletica-285	263	28	hagmann	hagmann	ADJ
ecletica-285	263	29	,	,	PUNCT
ecletica-285	263	30	w.k	w.k	PROPN
ecletica-285	263	31	.	.	PROPN
ecletica-285	263	32	;	;	PUNCT
ecletica-285	263	33	hermes	herme	NOUN
ecletica-285	263	34	,	,	PUNCT
ecletica-285	263	35	j.d	j.d	PROPN
ecletica-285	263	36	.	.	PROPN
ecletica-285	263	37	biochemistry	biochemistry	PROPN
ecletica-285	263	38	31	31	NUM
ecletica-285	263	39	(	(	PUNCT
ecletica-285	263	40	1992	1992	NUM
ecletica-285	263	41	)	)	PUNCT
ecletica-285	263	42	4535	4535	NUM
ecletica-285	263	43	.	.	PUNCT
ecletica-285	264	1	[	[	X
ecletica-285	264	2	6	6	NUM
ecletica-285	264	3	]	]	PUNCT
ecletica-285	264	4	bode	bode	NOUN
ecletica-285	264	5	,	,	PUNCT
ecletica-285	264	6	w.	w.	NOUN
ecletica-285	264	7	;	;	PUNCT
ecletica-285	264	8	reinemer	reinemer	NOUN
ecletica-285	264	9	,	,	PUNCT
ecletica-285	264	10	p.	p.	PROPN
ecletica-285	264	11	;	;	PUNCT
ecletica-285	264	12	huber	huber	PROPN
ecletica-285	264	13	,	,	PUNCT
ecletica-285	264	14	r.	r.	PROPN
ecletica-285	264	15	;	;	PUNCT
ecletica-285	264	16	kleine	kleine	PROPN
ecletica-285	264	17	,	,	PUNCT
ecletica-285	264	18	t.	t.	PROPN
ecletica-285	264	19	;	;	PUNCT
ecletica-285	264	20	schnierer	schnierer	PROPN
ecletica-285	264	21	,	,	PUNCT
ecletica-285	264	22	s.	s.	PROPN
ecletica-285	264	23	;	;	PUNCT
ecletica-285	264	24	tschesche	tschesche	PROPN
ecletica-285	264	25	,	,	PUNCT
ecletica-285	264	26	h.	h.	PROPN
ecletica-285	264	27	embo	embo	PROPN
ecletica-285	264	28	j.	j.	PROPN
ecletica-285	264	29	13	13	NUM
ecletica-285	264	30	(	(	PUNCT
ecletica-285	264	31	1994	1994	NUM
ecletica-285	264	32	)	)	PUNCT
ecletica-285	264	33	1263	1263	NUM
ecletica-285	264	34	.	.	PUNCT
ecletica-285	265	1	[	[	X
ecletica-285	265	2	7	7	NUM
ecletica-285	265	3	]	]	X
ecletica-285	265	4	borkakoti	borkakoti	NOUN
ecletica-285	265	5	,	,	PUNCT
ecletica-285	265	6	n.	n.	NOUN
ecletica-285	265	7	;	;	PUNCT
ecletica-285	265	8	winkler	winkler	NOUN
ecletica-285	265	9	,	,	PUNCT
ecletica-285	265	10	f.k	f.k	PROPN
ecletica-285	265	11	.	.	PROPN
ecletica-285	265	12	;	;	PUNCT
ecletica-285	265	13	williams	williams	PROPN
ecletica-285	265	14	,	,	PUNCT
ecletica-285	265	15	d.h	d.h	PROPN
ecletica-285	265	16	.	.	PROPN
ecletica-285	265	17	;	;	PUNCT
ecletica-285	265	18	d’arcy	d’arcy	PROPN
ecletica-285	265	19	,	,	PUNCT
ecletica-285	265	20	a.	a.	NOUN
ecletica-285	265	21	;	;	PUNCT
ecletica-285	265	22	broadhurst	broadhurst	PROPN
ecletica-285	265	23	,	,	PUNCT
ecletica-285	265	24	m.j	m.j	PROPN
ecletica-285	265	25	.	.	PROPN
ecletica-285	265	26	;	;	PUNCT
ecletica-285	265	27	brown	brown	PROPN
ecletica-285	265	28	,	,	PUNCT
ecletica-285	265	29	p.a	p.a	PROPN
ecletica-285	265	30	.	.	PROPN
ecletica-285	265	31	johnson	johnson	PROPN
ecletica-285	265	32	,	,	PUNCT
ecletica-285	265	33	w.h	w.h	PROPN
ecletica-285	265	34	.	.	PROPN
ecletica-285	265	35	;	;	PUNCT
ecletica-285	265	36	murray	murray	PROPN
ecletica-285	265	37	,	,	PUNCT
ecletica-285	265	38	e.j	e.j	PROPN
ecletica-285	265	39	.	.	PROPN
ecletica-285	265	40	struct	struct	NOUN
ecletica-285	265	41	.	.	PUNCT
ecletica-285	266	1	biol	biol	PROPN
ecletica-285	266	2	.	.	PUNCT
ecletica-285	267	1	1	1	NUM
ecletica-285	267	2	(	(	PUNCT
ecletica-285	267	3	1994	1994	NUM
ecletica-285	267	4	)	)	PUNCT
ecletica-285	267	5	106	106	NUM
ecletica-285	267	6	.	.	PUNCT
ecletica-285	268	1	[	[	X
ecletica-285	268	2	8	8	NUM
ecletica-285	268	3	]	]	X
ecletica-285	268	4	lovejoy	lovejoy	PROPN
ecletica-285	268	5	,	,	PUNCT
ecletica-285	268	6	b.	b.	PROPN
ecletica-285	268	7	;	;	PUNCT
ecletica-285	268	8	cleasby	cleasby	PROPN
ecletica-285	268	9	,	,	PUNCT
ecletica-285	268	10	a.	a.	NOUN
ecletica-285	268	11	;	;	PUNCT
ecletica-285	268	12	hassell	hassell	PROPN
ecletica-285	268	13	,	,	PUNCT
ecletica-285	268	14	a.m.	a.m.	ADV
ecletica-285	268	15	;	;	PUNCT
ecletica-285	268	16	longlely	longlely	ADV
ecletica-285	268	17	,	,	PUNCT
ecletica-285	268	18	k.	k.	PROPN
ecletica-285	268	19	;	;	PUNCT
ecletica-285	268	20	luther	luther	PROPN
ecletica-285	268	21	,	,	PUNCT
ecletica-285	268	22	m.a	m.a	PROPN
ecletica-285	268	23	.	.	PROPN
ecletica-285	268	24	;	;	PUNCT
ecletica-285	268	25	weigl	weigl	PROPN
ecletica-285	268	26	,	,	PUNCT
ecletica-285	268	27	d.	d.	PROPN
ecletica-285	268	28	;	;	PUNCT
ecletica-285	268	29	mcgeehan	mcgeehan	PROPN
ecletica-285	268	30	,	,	PUNCT
ecletica-285	268	31	g.	g.	PROPN
ecletica-285	268	32	;	;	PUNCT
ecletica-285	268	33	mcelroy	mcelroy	PROPN
ecletica-285	268	34	,	,	PUNCT
ecletica-285	268	35	a.b	a.b	PROPN
ecletica-285	268	36	.	.	PROPN
ecletica-285	268	37	;	;	PUNCT
ecletica-285	268	38	drewry	drewry	PROPN
ecletica-285	268	39	,	,	PUNCT
ecletica-285	268	40	d.	d.	PROPN
ecletica-285	268	41	;	;	PUNCT
ecletica-285	268	42	lambert	lambert	PROPN
ecletica-285	268	43	,	,	PUNCT
ecletica-285	268	44	m.h	m.h	PROPN
ecletica-285	268	45	.	.	PROPN
ecletica-285	268	46	;	;	PUNCT
ecletica-285	268	47	jordan	jordan	PROPN
ecletica-285	268	48	,	,	PUNCT
ecletica-285	268	49	s.r	s.r	PROPN
ecletica-285	268	50	.	.	PROPN
ecletica-285	268	51	science	science	PROPN
ecletica-285	268	52	263	263	NUM
ecletica-285	268	53	(	(	PUNCT
ecletica-285	268	54	1994	1994	NUM
ecletica-285	268	55	)	)	PUNCT
ecletica-285	268	56	375	375	NUM
ecletica-285	268	57	.	.	PUNCT
ecletica-285	269	1	[	[	X
ecletica-285	269	2	9	9	NUM
ecletica-285	269	3	]	]	SYM
ecletica-285	269	4	spurlino	spurlino	NOUN
ecletica-285	269	5	,	,	PUNCT
ecletica-285	269	6	j.c	j.c	PROPN
ecletica-285	269	7	.	.	PROPN
ecletica-285	269	8	;	;	PUNCT
ecletica-285	269	9	smallwood	smallwood	PROPN
ecletica-285	269	10	,	,	PUNCT
ecletica-285	269	11	a.m.	a.m.	PROPN
ecletica-285	269	12	;	;	PUNCT
ecletica-285	269	13	carlton	carlton	PROPN
ecletica-285	269	14	,	,	PUNCT
ecletica-285	269	15	d.d	d.d	PROPN
ecletica-285	269	16	.	.	PROPN
ecletica-285	269	17	;	;	PUNCT
ecletica-285	269	18	banks	bank	NOUN
ecletica-285	269	19	,	,	PUNCT
ecletica-285	269	20	t.m	t.m	PROPN
ecletica-285	269	21	.	.	PROPN
ecletica-285	269	22	;	;	PUNCT
ecletica-285	269	23	vavra	vavra	NOUN
ecletica-285	269	24	,	,	PUNCT
ecletica-285	269	25	k.j	k.j	PROPN
ecletica-285	269	26	.	.	PROPN
ecletica-285	269	27	;	;	PUNCT
ecletica-285	269	28	johnson	johnson	PROPN
ecletica-285	269	29	,	,	PUNCT
ecletica-285	269	30	j.s	j.s	PROPN
ecletica-285	269	31	.	.	PROPN
ecletica-285	269	32	;	;	PUNCT
ecletica-285	269	33	cook	cook	VERB
ecletica-285	269	34	,	,	PUNCT
ecletica-285	269	35	e.r	e.r	PROPN
ecletica-285	269	36	.	.	PROPN
ecletica-285	269	37	;	;	PUNCT
ecletica-285	269	38	falvo	falvo	PROPN
ecletica-285	269	39	,	,	PUNCT
ecletica-285	269	40	j.	j.	PROPN
ecletica-285	269	41	;	;	PUNCT
ecletica-285	269	42	wahl	wahl	PROPN
ecletica-285	269	43	,	,	PUNCT
ecletica-285	269	44	r.c	r.c	PROPN
ecletica-285	269	45	.	.	PROPN
ecletica-285	269	46	;	;	PUNCT
ecletica-285	269	47	pulvino	pulvino	NOUN
ecletica-285	269	48	,	,	PUNCT
ecletica-285	269	49	t.a	t.a	PROPN
ecletica-285	269	50	.	.	PROPN
ecletica-285	269	51	;	;	PUNCT
ecletica-285	269	52	wendoloski	wendoloski	PROPN
ecletica-285	269	53	,	,	PUNCT
ecletica-285	269	54	j.h	j.h	PROPN
ecletica-285	269	55	.	.	PROPN
ecletica-285	269	56	;	;	PUNCT
ecletica-285	269	57	smith	smith	PROPN
ecletica-285	269	58	,	,	PUNCT
ecletica-285	269	59	d.l	d.l	PROPN
ecletica-285	269	60	.	.	PROPN
ecletica-285	269	61	proteins	protein	NOUN
ecletica-285	269	62	19	19	NUM
ecletica-285	269	63	(	(	PUNCT
ecletica-285	269	64	1994	1994	NUM
ecletica-285	269	65	)	)	PUNCT
ecletica-285	269	66	98	98	NUM
ecletica-285	269	67	.	.	PUNCT
ecletica-285	270	1	[	[	X
ecletica-285	270	2	10	10	NUM
ecletica-285	270	3	]	]	X
ecletica-285	270	4	stams	stam	NOUN
ecletica-285	270	5	,	,	PUNCT
ecletica-285	270	6	t.	t.	PROPN
ecletica-285	270	7	;	;	PUNCT
ecletica-285	270	8	spurlino	spurlino	PROPN
ecletica-285	270	9	,	,	PUNCT
ecletica-285	270	10	j.c	j.c	PROPN
ecletica-285	270	11	.	.	PROPN
ecletica-285	270	12	;	;	PUNCT
ecletica-285	270	13	smith	smith	PROPN
ecletica-285	270	14	,	,	PUNCT
ecletica-285	270	15	d.l	d.l	PROPN
ecletica-285	270	16	.	.	PROPN
ecletica-285	270	17	;	;	PUNCT
ecletica-285	270	18	wahl	wahl	PROPN
ecletica-285	270	19	,	,	PUNCT
ecletica-285	270	20	r.c	r.c	PROPN
ecletica-285	270	21	.	.	PROPN
ecletica-285	270	22	;	;	PUNCT
ecletica-285	270	23	ho	ho	PROPN
ecletica-285	270	24	,	,	PUNCT
ecletica-285	270	25	t.f	t.f	PROPN
ecletica-285	270	26	.	.	PROPN
ecletica-285	270	27	;	;	PUNCT
ecletica-285	270	28	qoronfleh	qoronfleh	PROPN
ecletica-285	270	29	,	,	PUNCT
ecletica-285	270	30	m.w	m.w	PROPN
ecletica-285	270	31	.	.	PROPN
ecletica-285	270	32	;	;	PUNCT
ecletica-285	270	33	banks	bank	NOUN
ecletica-285	270	34	,	,	PUNCT
ecletica-285	270	35	t.m	t.m	PROPN
ecletica-285	270	36	.	.	PROPN
ecletica-285	270	37	;	;	PUNCT
ecletica-285	270	38	rubin	rubin	PROPN
ecletica-285	270	39	,	,	PUNCT
ecletica-285	270	40	b.	b.	PROPN
ecletica-285	270	41	struct	struct	NOUN
ecletica-285	270	42	.	.	PUNCT
ecletica-285	271	1	biol	biol	PROPN
ecletica-285	271	2	.	.	PUNCT
ecletica-285	272	1	1	1	NUM
ecletica-285	272	2	(	(	PUNCT
ecletica-285	272	3	1994	1994	NUM
ecletica-285	272	4	)	)	PUNCT
ecletica-285	272	5	119	119	NUM
ecletica-285	272	6	.	.	PUNCT
ecletica-285	273	1	[	[	X
ecletica-285	273	2	11	11	NUM
ecletica-285	273	3	]	]	SYM
ecletica-285	273	4	moy	moy	PROPN
ecletica-285	273	5	,	,	PUNCT
ecletica-285	273	6	f.j	f.j	PROPN
ecletica-285	273	7	.	.	PROPN
ecletica-285	273	8	;	;	PUNCT
ecletica-285	273	9	pisano	pisano	PROPN
ecletica-285	273	10	,	,	PUNCT
ecletica-285	273	11	m.r	m.r	PROPN
ecletica-285	273	12	.	.	PROPN
ecletica-285	273	13	;	;	PUNCT
ecletica-285	273	14	chanda	chanda	PROPN
ecletica-285	273	15	,	,	PUNCT
ecletica-285	273	16	p.k	p.k	PROPN
ecletica-285	273	17	.	.	PROPN
ecletica-285	273	18	;	;	PUNCT
ecletica-285	273	19	urbano	urbano	PROPN
ecletica-285	273	20	,	,	PUNCT
ecletica-285	273	21	c.	c.	PROPN
ecletica-285	273	22	;	;	PUNCT
ecletica-285	273	23	killar	killar	PROPN
ecletica-285	273	24	,	,	PUNCT
ecletica-285	273	25	l.m	l.m	PROPN
ecletica-285	273	26	.	.	PROPN
ecletica-285	273	27	;	;	PUNCT
ecletica-285	273	28	sung	sung	PROPN
ecletica-285	273	29	,	,	PUNCT
ecletica-285	273	30	l.	l.	PROPN
ecletica-285	273	31	;	;	PUNCT
ecletica-285	273	32	powers	power	NOUN
ecletica-285	273	33	,	,	PUNCT
ecletica-285	273	34	r.	r.	PROPN
ecletica-285	273	35	j.	j.	PROPN
ecletica-285	273	36	biomol	biomol	PROPN
ecletica-285	273	37	.	.	PUNCT
ecletica-285	274	1	nmr	nmr	NOUN
ecletica-285	274	2	1	1	NUM
ecletica-285	274	3	(	(	PUNCT
ecletica-285	274	4	1997	1997	NUM
ecletica-285	274	5	)	)	PUNCT
ecletica-285	274	6	9	9	NUM
ecletica-285	274	7	.	.	PUNCT
ecletica-285	275	1	[	[	X
ecletica-285	275	2	12	12	NUM
ecletica-285	275	3	]	]	PUNCT
ecletica-285	275	4	lovejoy	lovejoy	PROPN
ecletica-285	275	5	,	,	PUNCT
ecletica-285	275	6	b.	b.	PROPN
ecletica-285	275	7	;	;	PUNCT
ecletica-285	275	8	welch	welch	PROPN
ecletica-285	275	9	,	,	PUNCT
ecletica-285	275	10	a.r	a.r	PROPN
ecletica-285	275	11	.	.	PROPN
ecletica-285	275	12	;	;	PUNCT
ecletica-285	275	13	carr	carr	PROPN
ecletica-285	275	14	,	,	PUNCT
ecletica-285	275	15	s.	s.	PROPN
ecletica-285	275	16	;	;	PUNCT
ecletica-285	275	17	luong	luong	PROPN
ecletica-285	275	18	,	,	PUNCT
ecletica-285	275	19	c.	c.	PROPN
ecletica-285	275	20	;	;	PUNCT
ecletica-285	275	21	broka	broka	NOUN
ecletica-285	275	22	,	,	PUNCT
ecletica-285	275	23	c.	c.	PROPN
ecletica-285	275	24	;	;	PUNCT
ecletica-285	275	25	hendricks	hendrick	NOUN
ecletica-285	275	26	,	,	PUNCT
ecletica-285	275	27	r.t	r.t	PROPN
ecletica-285	275	28	.	.	PROPN
ecletica-285	275	29	;	;	PUNCT
ecletica-285	275	30	campbell	campbell	PROPN
ecletica-285	275	31	,	,	PUNCT
ecletica-285	275	32	j.a	j.a	PROPN
ecletica-285	275	33	.	.	PROPN
ecletica-285	275	34	;	;	PUNCT
ecletica-285	275	35	walker	walker	PROPN
ecletica-285	275	36	,	,	PUNCT
ecletica-285	275	37	k.a	k.a	PROPN
ecletica-285	275	38	.	.	PROPN
ecletica-285	275	39	;	;	PUNCT
ecletica-285	275	40	martin	martin	PROPN
ecletica-285	275	41	,	,	PUNCT
ecletica-285	275	42	r.	r.	PROPN
ecletica-285	275	43	;	;	PUNCT
ecletica-285	275	44	vanwart	vanwart	PROPN
ecletica-285	275	45	,	,	PUNCT
ecletica-285	275	46	h.	h.	PROPN
ecletica-285	275	47	;	;	PUNCT
ecletica-285	275	48	browner	browner	ADV
ecletica-285	275	49	,	,	PUNCT
ecletica-285	275	50	m.f	m.f	PROPN
ecletica-285	275	51	.	.	PROPN
ecletica-285	275	52	nat	nat	PROPN
ecletica-285	275	53	.	.	PUNCT
ecletica-285	275	54	struct	struct	NOUN
ecletica-285	275	55	.	.	PUNCT
ecletica-285	276	1	biol	biol	PROPN
ecletica-285	276	2	.	.	PUNCT
ecletica-285	277	1	6	6	NUM
ecletica-285	277	2	(	(	PUNCT
ecletica-285	277	3	1999	1999	NUM
ecletica-285	277	4	)	)	PUNCT
ecletica-285	277	5	217	217	NUM
ecletica-285	277	6	.	.	PUNCT
ecletica-285	278	1	[	[	X
ecletica-285	278	2	13	13	NUM
ecletica-285	278	3	]	]	X
ecletica-285	278	4	jozic	jozic	PROPN
ecletica-285	278	5	,	,	PUNCT
ecletica-285	278	6	d.	d.	PROPN
ecletica-285	278	7	;	;	PUNCT
ecletica-285	278	8	bourenkov	bourenkov	PROPN
ecletica-285	278	9	,	,	PUNCT
ecletica-285	278	10	g.	g.	PROPN
ecletica-285	278	11	;	;	PUNCT
ecletica-285	278	12	lim	lim	PROPN
ecletica-285	278	13	,	,	PUNCT
ecletica-285	278	14	n.h	n.h	PROPN
ecletica-285	278	15	.	.	PROPN
ecletica-285	278	16	;	;	PUNCT
ecletica-285	278	17	visse	visse	PROPN
ecletica-285	278	18	,	,	PUNCT
ecletica-285	278	19	r.	r.	PROPN
ecletica-285	278	20	;	;	PUNCT
ecletica-285	278	21	nagase	nagase	PROPN
ecletica-285	278	22	,	,	PUNCT
ecletica-285	278	23	h.	h.	PROPN
ecletica-285	278	24	;	;	PUNCT
ecletica-285	278	25	bode	bode	VERB
ecletica-285	278	26	,	,	PUNCT
ecletica-285	278	27	w.	w.	PROPN
ecletica-285	278	28	;	;	PUNCT
ecletica-285	278	29	maskos	maskos	PROPN
ecletica-285	278	30	,	,	PUNCT
ecletica-285	278	31	k.	k.	PROPN
ecletica-285	278	32	j.	j.	PROPN
ecletica-285	278	33	biol	biol	PROPN
ecletica-285	278	34	.	.	PUNCT
ecletica-285	279	1	chem	chem	PROPN
ecletica-285	279	2	.	.	PUNCT
ecletica-285	280	1	280	280	NUM
ecletica-285	280	2	(	(	PUNCT
ecletica-285	280	3	2005	2005	NUM
ecletica-285	280	4	)	)	PUNCT
ecletica-285	280	5	9578	9578	NUM
ecletica-285	280	6	.	.	PUNCT
ecletica-285	281	1	[	[	X
ecletica-285	281	2	14	14	NUM
ecletica-285	281	3	]	]	X
ecletica-285	281	4	gooley	gooley	PROPN
ecletica-285	281	5	,	,	PUNCT
ecletica-285	281	6	p.r	p.r	PROPN
ecletica-285	281	7	.	.	PROPN
ecletica-285	281	8	;	;	PUNCT
ecletica-285	281	9	johnson	johnson	PROPN
ecletica-285	281	10	,	,	PUNCT
ecletica-285	281	11	b.a	b.a	PROPN
ecletica-285	281	12	.	.	PROPN
ecletica-285	281	13	;	;	PUNCT
ecletica-285	281	14	marcy	marcy	PROPN
ecletica-285	281	15	,	,	PUNCT
ecletica-285	281	16	a.i	a.i	PROPN
ecletica-285	281	17	.	.	PROPN
ecletica-285	281	18	;	;	PUNCT
ecletica-285	281	19	cuca	cuca	PROPN
ecletica-285	281	20	,	,	PUNCT
ecletica-285	281	21	g.c	g.c	PROPN
ecletica-285	281	22	.	.	PROPN
ecletica-285	281	23	;	;	PUNCT
ecletica-285	281	24	salowe	salowe	PROPN
ecletica-285	281	25	,	,	PUNCT
ecletica-285	281	26	s.p	s.p	PROPN
ecletica-285	281	27	.	.	PROPN
ecletica-285	281	28	;	;	PUNCT
ecletica-285	281	29	hagmann	hagmann	PROPN
ecletica-285	281	30	,	,	PUNCT
ecletica-285	281	31	w.k	w.k	PROPN
ecletica-285	281	32	.	.	PROPN
ecletica-285	281	33	;	;	PUNCT
ecletica-285	281	34	esser	esser	PROPN
ecletica-285	281	35	,	,	PUNCT
ecletica-285	281	36	c.k	c.k	PROPN
ecletica-285	281	37	.	.	PROPN
ecletica-285	281	38	;	;	PUNCT
ecletica-285	281	39	springer	springer	NOUN
ecletica-285	281	40	,	,	PUNCT
ecletica-285	281	41	j.p	j.p	PROPN
ecletica-285	281	42	.	.	PROPN
ecletica-285	281	43	biochemistry	biochemistry	PROPN
ecletica-285	281	44	32	32	NUM
ecletica-285	281	45	(	(	PUNCT
ecletica-285	281	46	1993	1993	NUM
ecletica-285	281	47	)	)	PUNCT
ecletica-285	281	48	13098	13098	NUM
ecletica-285	281	49	.	.	PUNCT
ecletica-285	282	1	[	[	X
ecletica-285	282	2	15	15	NUM
ecletica-285	282	3	]	]	X
ecletica-285	282	4	gooley	gooley	ADJ
ecletica-285	282	5	,	,	PUNCT
ecletica-285	282	6	p.r	p.r	PROPN
ecletica-285	282	7	.	.	PROPN
ecletica-285	282	8	;	;	PUNCT
ecletica-285	283	1	o’connell	o’connell	PROPN
ecletica-285	283	2	,	,	PUNCT
ecletica-285	283	3	j.f	j.f	PROPN
ecletica-285	283	4	.	.	PROPN
ecletica-285	283	5	;	;	PUNCT
ecletica-285	283	6	marcy	marcy	PROPN
ecletica-285	283	7	,	,	PUNCT
ecletica-285	283	8	a.i	a.i	PROPN
ecletica-285	283	9	.	.	PROPN
ecletica-285	283	10	;	;	PUNCT
ecletica-285	283	11	cuca	cuca	PROPN
ecletica-285	283	12	,	,	PUNCT
ecletica-285	283	13	g.c	g.c	PROPN
ecletica-285	283	14	.	.	PROPN
ecletica-285	283	15	;	;	PUNCT
ecletica-285	283	16	salowe	salowe	PROPN
ecletica-285	283	17	,	,	PUNCT
ecletica-285	283	18	s.p	s.p	PROPN
ecletica-285	283	19	.	.	PROPN
ecletica-285	283	20	;	;	PUNCT
ecletica-285	283	21	bush	bush	PROPN
ecletica-285	283	22	,	,	PUNCT
ecletica-285	283	23	b.l	b.l	PROPN
ecletica-285	283	24	.	.	PROPN
ecletica-285	283	25	;	;	PUNCT
ecletica-285	283	26	hermes	herme	NOUN
ecletica-285	283	27	,	,	PUNCT
ecletica-285	283	28	j.d	j.d	PROPN
ecletica-285	283	29	.	.	PROPN
ecletica-285	283	30	;	;	PUNCT
ecletica-285	283	31	esser	esser	PROPN
ecletica-285	283	32	,	,	PUNCT
ecletica-285	283	33	c.k	c.k	PROPN
ecletica-285	283	34	.	.	PROPN
ecletica-285	283	35	;	;	PUNCT
ecletica-285	283	36	hag	hag	NOUN
ecletica-285	283	37	-	-	PUNCT
ecletica-285	283	38	hermes	herme	NOUN
ecletica-285	283	39	,	,	PUNCT
ecletica-285	283	40	j.d	j.d	PROPN
ecletica-285	283	41	.	.	PROPN
ecletica-285	283	42	;	;	PUNCT
ecletica-285	283	43	esser	esser	PROPN
ecletica-285	283	44	,	,	PUNCT
ecletica-285	283	45	c.k	c.k	PROPN
ecletica-285	283	46	.	.	PROPN
ecletica-285	283	47	;	;	PUNCT
ecletica-285	283	48	hagmann	hagmann	PROPN
ecletica-285	283	49	,	,	PUNCT
ecletica-285	283	50	w.k	w.k	PROPN
ecletica-285	283	51	.	.	PROPN
ecletica-285	283	52	;	;	PUNCT
ecletica-285	283	53	springer	springer	NOUN
ecletica-285	283	54	,	,	PUNCT
ecletica-285	283	55	j.p	j.p	PROPN
ecletica-285	283	56	.	.	PROPN
ecletica-285	283	57	;	;	PUNCT
ecletica-285	283	58	johnson	johnson	PROPN
ecletica-285	283	59	,	,	PUNCT
ecletica-285	283	60	b.a	b.a	PROPN
ecletica-285	283	61	.	.	PROPN
ecletica-285	283	62	struct	struct	NOUN
ecletica-285	283	63	.	.	PUNCT
ecletica-285	284	1	biol	biol	PROPN
ecletica-285	284	2	.	.	PUNCT
ecletica-285	285	1	1	1	NUM
ecletica-285	285	2	(	(	PUNCT
ecletica-285	285	3	1994	1994	NUM
ecletica-285	285	4	)	)	PUNCT
ecletica-285	285	5	111	111	NUM
ecletica-285	285	6	.	.	PUNCT
ecletica-285	286	1	[	[	X
ecletica-285	286	2	16	16	NUM
ecletica-285	286	3	]	]	X
ecletica-285	286	4	van	van	PROPN
ecletica-285	286	5	doren	doren	PROPN
ecletica-285	286	6	,	,	PUNCT
ecletica-285	286	7	s.r	s.r	PROPN
ecletica-285	286	8	.	.	PROPN
ecletica-285	286	9	;	;	PUNCT
ecletica-285	286	10	kurochkin	kurochkin	PROPN
ecletica-285	286	11	,	,	PUNCT
ecletica-285	286	12	a.v	a.v	PROPN
ecletica-285	286	13	.	.	PROPN
ecletica-285	286	14	;	;	PUNCT
ecletica-285	286	15	hu	hu	PROPN
ecletica-285	286	16	,	,	PUNCT
ecletica-285	286	17	w.	w.	PROPN
ecletica-285	286	18	;	;	PUNCT
ecletica-285	286	19	ye	ye	PROPN
ecletica-285	286	20	,	,	PUNCT
ecletica-285	286	21	q.z	q.z	PROPN
ecletica-285	286	22	.	.	PROPN
ecletica-285	286	23	;	;	PUNCT
ecletica-285	286	24	johnson	johnson	PROPN
ecletica-285	286	25	,	,	PUNCT
ecletica-285	286	26	l.l	l.l	PROPN
ecletica-285	286	27	.	.	PROPN
ecletica-285	286	28	;	;	PUNCT
ecletica-285	286	29	hupe	hupe	NOUN
ecletica-285	286	30	,	,	PUNCT
ecletica-285	286	31	d.j	d.j	PROPN
ecletica-285	286	32	.	.	PROPN
ecletica-285	286	33	;	;	PUNCT
ecletica-285	286	34	zuiderweg	zuiderweg	PROPN
ecletica-285	286	35	,	,	PUNCT
ecletica-285	286	36	e.r	e.r	PROPN
ecletica-285	286	37	.	.	PROPN
ecletica-285	286	38	protein	protein	PROPN
ecletica-285	286	39	sci	sci	PROPN
ecletica-285	286	40	.	.	PROPN
ecletica-285	286	41	4	4	NUM
ecletica-285	286	42	(	(	PUNCT
ecletica-285	286	43	1995	1995	NUM
ecletica-285	286	44	)	)	PUNCT
ecletica-285	286	45	2487	2487	NUM
ecletica-285	286	46	.	.	PUNCT
ecletica-285	287	1	[	[	X
ecletica-285	287	2	17	17	NUM
ecletica-285	287	3	]	]	X
ecletica-285	287	4	gooley	gooley	PROPN
ecletica-285	287	5	,	,	PUNCT
ecletica-285	287	6	p.r	p.r	PROPN
ecletica-285	287	7	.	.	PROPN
ecletica-285	287	8	;	;	PUNCT
ecletica-285	288	1	o‘connell	o‘connell	PROPN
ecletica-285	288	2	,	,	PUNCT
ecletica-285	288	3	j.f	j.f	PROPN
ecletica-285	288	4	.	.	PROPN
ecletica-285	288	5	;	;	PUNCT
ecletica-285	288	6	marcy	marcy	PROPN
ecletica-285	288	7	,	,	PUNCT
ecletica-285	288	8	a.i	a.i	PROPN
ecletica-285	288	9	.	.	PROPN
ecletica-285	288	10	;	;	PUNCT
ecletica-285	288	11	cuca	cuca	PROPN
ecletica-285	288	12	,	,	PUNCT
ecletica-285	288	13	g.c	g.c	PROPN
ecletica-285	288	14	.	.	PROPN
ecletica-285	288	15	;	;	PUNCT
ecletica-285	288	16	axel	axel	PROPN
ecletica-285	288	17	,	,	PUNCT
ecletica-285	288	18	m.g	m.g	PROPN
ecletica-285	288	19	.	.	PROPN
ecletica-285	288	20	;	;	PUNCT
ecletica-285	288	21	caldwell	caldwell	PROPN
ecletica-285	288	22	,	,	PUNCT
ecletica-285	288	23	c.g	c.g	PROPN
ecletica-285	288	24	.	.	PROPN
ecletica-285	288	25	;	;	PUNCT
ecletica-285	288	26	hagmann	hagmann	PROPN
ecletica-285	288	27	,	,	PUNCT
ecletica-285	288	28	w.k	w.k	PROPN
ecletica-285	288	29	.	.	PROPN
ecletica-285	288	30	;	;	PUNCT
ecletica-285	288	31	becker	becker	PROPN
ecletica-285	288	32	,	,	PUNCT
ecletica-285	288	33	j.w	j.w	PROPN
ecletica-285	288	34	.	.	PUNCT
ecletica-285	288	35	j.	j.	PROPN
ecletica-285	288	36	biomol	biomol	PROPN
ecletica-285	288	37	nmr	nmr	NOUN
ecletica-285	288	38	7	7	NUM
ecletica-285	288	39	(	(	PUNCT
ecletica-285	288	40	1996	1996	NUM
ecletica-285	288	41	)	)	PUNCT
ecletica-285	288	42	8	8	NUM
ecletica-285	288	43	.	.	PUNCT
ecletica-285	289	1	[	[	X
ecletica-285	289	2	18	18	NUM
ecletica-285	289	3	]	]	PUNCT
ecletica-285	289	4	dhanaraj	dhanaraj	NOUN
ecletica-285	289	5	,	,	PUNCT
ecletica-285	289	6	v.	v.	ADP
ecletica-285	289	7	;	;	PUNCT
ecletica-285	289	8	ye	ye	PROPN
ecletica-285	289	9	,	,	PUNCT
ecletica-285	289	10	q.z	q.z	PROPN
ecletica-285	289	11	.	.	PROPN
ecletica-285	289	12	;	;	PUNCT
ecletica-285	289	13	johnson	johnson	PROPN
ecletica-285	289	14	,	,	PUNCT
ecletica-285	289	15	l.l	l.l	PROPN
ecletica-285	289	16	.	.	PROPN
ecletica-285	289	17	;	;	PUNCT
ecletica-285	289	18	hupe	hupe	NOUN
ecletica-285	289	19	,	,	PUNCT
ecletica-285	289	20	d.j	d.j	PROPN
ecletica-285	289	21	.	.	PROPN
ecletica-285	289	22	;	;	PUNCT
ecletica-285	289	23	ortwine	ortwine	NOUN
ecletica-285	289	24	,	,	PUNCT
ecletica-285	289	25	d.f	d.f	PROPN
ecletica-285	289	26	.	.	PROPN
ecletica-285	289	27	;	;	PUNCT
ecletica-285	289	28	dunbar	dunbar	PROPN
ecletica-285	289	29	,	,	PUNCT
ecletica-285	289	30	j.b	j.b	PROPN
ecletica-285	289	31	.	.	PROPN
ecletica-285	289	32	,	,	PUNCT
ecletica-285	289	33	jr	jr	PROPN
ecletica-285	289	34	;	;	PUNCT
ecletica-285	289	35	rubin	rubin	PROPN
ecletica-285	289	36	,	,	PUNCT
ecletica-285	289	37	j.r	j.r	PROPN
ecletica-285	289	38	.	.	PROPN
ecletica-285	289	39	;	;	PUNCT
ecletica-285	289	40	pavlovsky	pavlovsky	PROPN
ecletica-285	289	41	,	,	PUNCT
ecletica-285	289	42	a.	a.	NOUN
ecletica-285	289	43	;	;	PUNCT
ecletica-285	289	44	humblet	humblet	PROPN
ecletica-285	289	45	,	,	PUNCT
ecletica-285	289	46	c.	c.	PROPN
ecletica-285	289	47	;	;	PUNCT
ecletica-285	289	48	blundell	blundell	PROPN
ecletica-285	289	49	,	,	PUNCT
ecletica-285	289	50	t.l	t.l	PROPN
ecletica-285	289	51	.	.	PROPN
ecletica-285	289	52	structure	structure	NOUN
ecletica-285	289	53	15	15	NUM
ecletica-285	289	54	(	(	PUNCT
ecletica-285	289	55	1996	1996	NUM
ecletica-285	289	56	)	)	PUNCT
ecletica-285	289	57	375	375	NUM
ecletica-285	289	58	.	.	PUNCT
ecletica-285	290	1	[	[	X
ecletica-285	290	2	19	19	NUM
ecletica-285	290	3	]	]	X
ecletica-285	290	4	capalonga	capalonga	PROPN
ecletica-285	290	5	,	,	PUNCT
ecletica-285	290	6	a.m.	a.m.	ADV
ecletica-285	290	7	;	;	PUNCT
ecletica-285	290	8	alexander	alexander	PROPN
ecletica-285	290	9	,	,	PUNCT
ecletica-285	290	10	r.s	r.s	PROPN
ecletica-285	290	11	.	.	PROPN
ecletica-285	290	12	;	;	PUNCT
ecletica-285	290	13	christianson	christianson	PROPN
ecletica-285	290	14	,	,	PUNCT
ecletica-285	290	15	d.w	d.w	PROPN
ecletica-285	290	16	.	.	PROPN
ecletica-285	290	17	j.	j.	PROPN
ecletica-285	290	18	biol	biol	PROPN
ecletica-285	290	19	.	.	PUNCT
ecletica-285	291	1	chem	chem	PROPN
ecletica-285	291	2	.	.	PUNCT
ecletica-285	292	1	267	267	NUM
ecletica-285	292	2	(	(	PUNCT
ecletica-285	292	3	1992	1992	NUM
ecletica-285	292	4	)	)	PUNCT
ecletica-285	292	5	19192	19192	NUM
ecletica-285	292	6	.	.	PUNCT
ecletica-285	293	1	[	[	X
ecletica-285	293	2	20	20	NUM
ecletica-285	293	3	]	]	X
ecletica-285	293	4	qing	qing	NOUN
ecletica-285	293	5	-	-	PUNCT
ecletica-285	293	6	xiang	xiang	PROPN
ecletica-285	293	7	,	,	PUNCT
ecletica-285	293	8	a.s.;1	a.s.;1	ADP
ecletica-285	293	9	meng	meng	PROPN
ecletica-285	293	10	-	-	PUNCT
ecletica-285	293	11	chun	chun	PROPN
ecletica-285	293	12	,	,	PUNCT
ecletica-285	293	13	j.	j.	PROPN
ecletica-285	293	14	;	;	PUNCT
ecletica-285	293	15	schwartz	schwartz	PROPN
ecletica-285	293	16	,	,	PUNCT
ecletica-285	293	17	m.a	m.a	PROPN
ecletica-285	293	18	.	.	PROPN
ecletica-285	293	19	;	;	PUNCT
ecletica-285	293	20	jaye	jaye	PROPN
ecletica-285	293	21	,	,	PUNCT
ecletica-285	293	22	m.c	m.c	PROPN
ecletica-285	293	23	.	.	PROPN
ecletica-285	293	24	;	;	PUNCT
ecletica-285	293	25	kleinman	kleinman	PROPN
ecletica-285	293	26	,	,	PUNCT
ecletica-285	293	27	h.k	h.k	PROPN
ecletica-285	293	28	.	.	PROPN
ecletica-285	293	29	;	;	PUNCT
ecletica-285	293	30	ghaffari	ghaffari	PROPN
ecletica-285	293	31	,	,	PUNCT
ecletica-285	293	32	m.a	m.a	PROPN
ecletica-285	293	33	.	.	PROPN
ecletica-285	293	34	;	;	PUNCT
ecletica-285	293	35	yi	yi	PROPN
ecletica-285	293	36	-	-	PUNCT
ecletica-285	293	37	lin	lin	PROPN
ecletica-285	293	38	,	,	PUNCT
ecletica-285	293	39	l.	l.	PROPN
ecletica-285	293	40	biochem	biochem	PROPN
ecletica-285	293	41	.	.	PUNCT
ecletica-285	294	1	biophys	biophy	NOUN
ecletica-285	294	2	.	.	PUNCT
ecletica-285	295	1	res	re	NOUN
ecletica-285	295	2	.	.	PUNCT
ecletica-285	296	1	commun	commun	PROPN
ecletica-285	296	2	.	.	PUNCT
ecletica-285	297	1	274	274	NUM
ecletica-285	297	2	(	(	PUNCT
ecletica-285	297	3	2000	2000	NUM
ecletica-285	297	4	)	)	PUNCT
ecletica-285	297	5	780	780	NUM
ecletica-285	297	6	.	.	PUNCT
ecletica-285	298	1	[	[	X
ecletica-285	298	2	21	21	NUM
ecletica-285	298	3	]	]	X
ecletica-285	298	4	schwartz	schwartz	PROPN
ecletica-285	298	5	,	,	PUNCT
ecletica-285	298	6	m.a	m.a	PROPN
ecletica-285	298	7	.	.	PROPN
ecletica-285	298	8	;	;	PUNCT
ecletica-285	298	9	wart	wart	NOUN
ecletica-285	298	10	,	,	PUNCT
ecletica-285	298	11	h.	h.	PROPN
ecletica-285	298	12	van	van	PROPN
ecletica-285	298	13	.	.	PUNCT
ecletica-285	299	1	us	us	PROPN
ecletica-285	299	2	patent	patent	NOUN
ecletica-285	299	3	9.509.620	9.509.620	NUM
ecletica-285	299	4	,	,	PUNCT
ecletica-285	299	5	1995	1995	NUM
ecletica-285	299	6	.	.	PUNCT
ecletica-285	300	1	[	[	X
ecletica-285	300	2	22	22	NUM
ecletica-285	300	3	]	]	X
ecletica-285	300	4	teronen	teronen	NOUN
ecletica-285	300	5	,	,	PUNCT
ecletica-285	300	6	o.	o.	PROPN
ecletica-285	300	7	;	;	PUNCT
ecletica-285	300	8	heikkila	heikkila	PROPN
ecletica-285	300	9	,	,	PUNCT
ecletica-285	300	10	p.	p.	NOUN
ecletica-285	300	11	;	;	PUNCT
ecletica-285	300	12	konttinen	konttinen	PROPN
ecletica-285	300	13	,	,	PUNCT
ecletica-285	300	14	y.	y.	PROPN
ecletica-285	300	15	;	;	PUNCT
ecletica-285	300	16	laitinen	laitinen	PROPN
ecletica-285	300	17	,	,	PUNCT
ecletica-285	300	18	m.	m.	NOUN
ecletica-285	300	19	;	;	PUNCT
ecletica-285	300	20	salo	salo	NOUN
ecletica-285	300	21	,	,	PUNCT
ecletica-285	300	22	t.	t.	PROPN
ecletica-285	300	23	;	;	PUNCT
ecletica-285	300	24	hanemaaijer	hanemaaijer	PROPN
ecletica-285	300	25	,	,	PUNCT
ecletica-285	300	26	r.	r.	PROPN
ecletica-285	300	27	;	;	PUNCT
ecletica-285	300	28	teronen	teronen	NOUN
ecletica-285	300	29	,	,	PUNCT
ecletica-285	300	30	a.	a.	NOUN
ecletica-285	300	31	;	;	PUNCT
ecletica-285	300	32	sorsa	sorsa	ADV
ecletica-285	300	33	,	,	PUNCT
ecletica-285	300	34	t.	t.	PROPN
ecletica-285	300	35	p.	p.	NOUN
ecletica-285	300	36	453	453	NUM
ecletica-285	300	37	-	-	SYM
ecletica-285	300	38	465	465	NUM
ecletica-285	300	39	;	;	PUNCT
ecletica-285	300	40	barracchini	barracchini	NOUN
ecletica-285	300	41	,	,	PUNCT
ecletica-285	300	42	a.	a.	NOUN
ecletica-285	300	43	;	;	PUNCT
ecletica-285	300	44	franceschini	franceschini	PROPN
ecletica-285	300	45	,	,	PUNCT
ecletica-285	300	46	n.	n.	NOUN
ecletica-285	300	47	;	;	PUNCT
ecletica-285	300	48	minisola	minisola	PROPN
ecletica-285	300	49	,	,	PUNCT
ecletica-285	300	50	g.	g.	PROPN
ecletica-285	300	51	;	;	PUNCT
ecletica-285	300	52	pantaleoni	pantaleoni	PROPN
ecletica-285	300	53	,	,	PUNCT
ecletica-285	300	54	g.c	g.c	PROPN
ecletica-285	300	55	.	.	PROPN
ecletica-285	300	56	;	;	PUNCT
ecletica-285	300	57	di	di	PROPN
ecletica-285	300	58	giulio	giulio	PROPN
ecletica-285	300	59	,	,	PUNCT
ecletica-285	300	60	a.	a.	NOUN
ecletica-285	300	61	;	;	PUNCT
ecletica-285	300	62	oratore	oratore	NOUN
ecletica-285	300	63	,	,	PUNCT
ecletica-285	300	64	a.	a.	NOUN
ecletica-285	300	65	;	;	PUNCT
ecletica-285	300	66	amicosante	amicosante	PROPN
ecletica-285	300	67	,	,	PUNCT
ecletica-285	300	68	g.	g.	PROPN
ecletica-285	300	69	p.	p.	NOUN
ecletica-285	300	70	665	665	NUM
ecletica-285	300	71	-	-	SYM
ecletica-285	300	72	666	666	NUM
ecletica-285	300	73	;	;	PUNCT
ecletica-285	300	74	llavaneras	llavaneras	PROPN
ecletica-285	300	75	,	,	PUNCT
ecletica-285	300	76	a.	a.	NOUN
ecletica-285	300	77	;	;	PUNCT
ecletica-285	300	78	golub	golub	PROPN
ecletica-285	300	79	,	,	PUNCT
ecletica-285	300	80	l.m	l.m	PROPN
ecletica-285	300	81	.	.	PROPN
ecletica-285	300	82	;	;	PUNCT
ecletica-285	300	83	rifkin	rifkin	PROPN
ecletica-285	300	84	,	,	PUNCT
ecletica-285	300	85	b.r	b.r	PROPN
ecletica-285	300	86	.	.	PROPN
ecletica-285	300	87	;	;	PUNCT
ecletica-285	300	88	heikkilä	heikkilä	PROPN
ecletica-285	300	89	,	,	PUNCT
ecletica-285	300	90	p.	p.	NOUN
ecletica-285	300	91	;	;	PUNCT
ecletica-285	300	92	sorsa	sorsa	NOUN
ecletica-285	300	93	,	,	PUNCT
ecletica-285	300	94	t.	t.	PROPN
ecletica-285	300	95	;	;	PUNCT
ecletica-285	300	96	teronen	teronen	PROPN
ecletica-285	300	97	,	,	PUNCT
ecletica-285	300	98	o.	o.	PROPN
ecletica-285	300	99	;	;	PUNCT
ecletica-285	300	100	salo	salo	PROPN
ecletica-285	300	101	,	,	PUNCT
ecletica-285	300	102	t.	t.	PROPN
ecletica-285	300	103	;	;	PUNCT
ecletica-285	300	104	liu	liu	PROPN
ecletica-285	300	105	,	,	PUNCT
ecletica-285	300	106	y.	y.	PROPN
ecletica-285	300	107	;	;	PUNCT
ecletica-285	300	108	ryan	ryan	PROPN
ecletica-285	300	109	,	,	PUNCT
ecletica-285	300	110	m.e	m.e	PROPN
ecletica-285	300	111	.	.	PROPN
ecletica-285	300	112	;	;	PUNCT
ecletica-285	300	113	ramamurthy	ramamurthy	PROPN
ecletica-285	300	114	,	,	PUNCT
ecletica-285	300	115	n.s	n.s	PROPN
ecletica-285	300	116	.	.	PUNCT
ecletica-285	301	1	p.	p.	NOUN
ecletica-285	301	2	671	671	NUM
ecletica-285	301	3	-	-	SYM
ecletica-285	301	4	674	674	NUM
ecletica-285	301	5	;	;	PUNCT
ecletica-285	301	6	all	all	DET
ecletica-285	301	7	articles	article	NOUN
ecletica-285	301	8	in	in	ADP
ecletica-285	301	9	:	:	PUNCT
ecletica-285	301	10	annals	annal	NOUN
ecletica-285	301	11	of	of	ADP
ecletica-285	301	12	the	the	DET
ecletica-285	301	13	new	new	PROPN
ecletica-285	301	14	york	york	PROPN
ecletica-285	301	15	academy	academy	PROPN
ecletica-285	301	16	of	of	ADP
ecletica-285	301	17	sciences	sciences	PROPN
ecletica-285	301	18	,	,	PUNCT
ecletica-285	301	19	volume	volume	NOUN
ecletica-285	301	20	878	878	NUM
ecletica-285	301	21	,	,	PUNCT
ecletica-285	301	22	1999	1999	NUM
ecletica-285	301	23	.	.	PUNCT
ecletica-285	302	1	[	[	X
ecletica-285	302	2	23	23	NUM
ecletica-285	302	3	]	]	X
ecletica-285	302	4	knight	knight	NOUN
ecletica-285	302	5	,	,	PUNCT
ecletica-285	302	6	c.g	c.g	PROPN
ecletica-285	302	7	.	.	PROPN
ecletica-285	302	8	;	;	PUNCT
ecletica-285	302	9	willenbrock	willenbrock	VERB
ecletica-285	302	10	,	,	PUNCT
ecletica-285	302	11	f.	f.	PROPN
ecletica-285	302	12	;	;	PUNCT
ecletica-285	302	13	murphy	murphy	PROPN
ecletica-285	302	14	,	,	PUNCT
ecletica-285	302	15	g.	g.	PROPN
ecletica-285	302	16	febs	febs	PROPN
ecletica-285	302	17	letters	letter	NOUN
ecletica-285	302	18	296	296	NUM
ecletica-285	302	19	(	(	PUNCT
ecletica-285	302	20	1992	1992	NUM
ecletica-285	302	21	)	)	PUNCT
ecletica-285	302	22	263	263	NUM
ecletica-285	302	23	.	.	PUNCT
ecletica-285	303	1	[	[	X
ecletica-285	303	2	24	24	NUM
ecletica-285	303	3	]	]	PUNCT
ecletica-285	303	4	lovejoy	lovejoy	PROPN
ecletica-285	303	5	,	,	PUNCT
ecletica-285	303	6	b.	b.	PROPN
ecletica-285	303	7	;	;	PUNCT
ecletica-285	303	8	cleasby	cleasby	PROPN
ecletica-285	303	9	,	,	PUNCT
ecletica-285	303	10	a.	a.	NOUN
ecletica-285	303	11	;	;	PUNCT
ecletica-285	303	12	hassell	hassell	PROPN
ecletica-285	303	13	,	,	PUNCT
ecletica-285	303	14	a.m.	a.m.	ADV
ecletica-285	303	15	;	;	PUNCT
ecletica-285	303	16	longlely	longlely	ADV
ecletica-285	303	17	,	,	PUNCT
ecletica-285	303	18	k.	k.	PROPN
ecletica-285	303	19	;	;	PUNCT
ecletica-285	303	20	luther	luther	PROPN
ecletica-285	303	21	,	,	PUNCT
ecletica-285	303	22	m.a	m.a	PROPN
ecletica-285	303	23	.	.	PROPN
ecletica-285	303	24	;	;	PUNCT
ecletica-285	303	25	weigl	weigl	PROPN
ecletica-285	303	26	,	,	PUNCT
ecletica-285	303	27	d.	d.	PROPN
ecletica-285	303	28	;	;	PUNCT
ecletica-285	303	29	mcgeehan	mcgeehan	PROPN
ecletica-285	303	30	,	,	PUNCT
ecletica-285	303	31	g.	g.	PROPN
ecletica-285	303	32	;	;	PUNCT
ecletica-285	303	33	mcelroy	mcelroy	PROPN
ecletica-285	303	34	,	,	PUNCT
ecletica-285	303	35	a.b	a.b	PROPN
ecletica-285	303	36	.	.	PROPN
ecletica-285	303	37	;	;	PUNCT
ecletica-285	303	38	drewry	drewry	PROPN
ecletica-285	303	39	,	,	PUNCT
ecletica-285	303	40	d.	d.	PROPN
ecletica-285	303	41	;	;	PUNCT
ecletica-285	303	42	lambert	lambert	PROPN
ecletica-285	303	43	,	,	PUNCT
ecletica-285	303	44	m.h	m.h	PROPN
ecletica-285	303	45	.	.	PROPN
ecletica-285	303	46	;	;	PUNCT
ecletica-285	303	47	jordan	jordan	PROPN
ecletica-285	303	48	,	,	PUNCT
ecletica-285	303	49	s.r	s.r	PROPN
ecletica-285	303	50	.	.	PROPN
ecletica-285	303	51	science	science	PROPN
ecletica-285	303	52	263	263	NUM
ecletica-285	303	53	(	(	PUNCT
ecletica-285	303	54	1994	1994	NUM
ecletica-285	303	55	)	)	PUNCT
ecletica-285	303	56	375	375	NUM
ecletica-285	303	57	.	.	PUNCT
ecletica-285	304	1	[	[	X
ecletica-285	304	2	25	25	NUM
ecletica-285	304	3	]	]	PUNCT
ecletica-285	304	4	protein	protein	NOUN
ecletica-285	304	5	data	data	PROPN
ecletica-285	304	6	bank	bank	PROPN
ecletica-285	304	7	,	,	PUNCT
ecletica-285	304	8	brookhaven	brookhaven	PROPN
ecletica-285	304	9	national	national	PROPN
ecletica-285	304	10	laboratory	laboratory	PROPN
ecletica-285	304	11	.	.	PUNCT
ecletica-285	305	1	structure	structure	NOUN
ecletica-285	305	2	1cgl	1cgl	PROPN
ecletica-285	305	3	.	.	PUNCT
ecletica-285	306	1	[	[	X
ecletica-285	306	2	26	26	NUM
ecletica-285	306	3	]	]	PUNCT
ecletica-285	306	4	cache	cache	NOUN
ecletica-285	306	5	5.0	5.0	NUM
ecletica-285	306	6	user	user	NOUN
ecletica-285	306	7	guide	guide	NOUN
ecletica-285	306	8	,	,	PUNCT
ecletica-285	306	9	fujitsu	fujitsu	PROPN
ecletica-285	306	10	systems	systems	PROPN
ecletica-285	306	11	business	business	PROPN
ecletica-285	306	12	of	of	ADP
ecletica-285	306	13	america	america	PROPN
ecletica-285	306	14	,	,	PUNCT
ecletica-285	306	15	inc	inc	PROPN
ecletica-285	306	16	.	.	PROPN
ecletica-285	306	17	,	,	PUNCT
ecletica-285	306	18	beaverton	beaverton	PROPN
ecletica-285	306	19	,	,	PUNCT
ecletica-285	306	20	usa	usa	PROPN
ecletica-285	306	21	,	,	PUNCT
ecletica-285	306	22	2001	2001	NUM
ecletica-285	306	23	.	.	PUNCT
ecletica-285	307	1	[	[	X
ecletica-285	307	2	27	27	NUM
ecletica-285	307	3	]	]	SYM
ecletica-285	307	4	hyperchem	hyperchem	NOUN
ecletica-285	307	5	.	.	PUNCT
ecletica-285	307	6	,	,	PUNCT
ecletica-285	307	7	computational	computational	ADJ
ecletica-285	307	8	chemistry	chemistry	NOUN
ecletica-285	307	9	,	,	PUNCT
ecletica-285	307	10	hypercube	hypercube	PROPN
ecletica-285	307	11	inc	inc	PROPN
ecletica-285	307	12	.	.	PROPN
ecletica-285	307	13	,	,	PUNCT
ecletica-285	307	14	waterloo	waterloo	PROPN
ecletica-285	307	15	,	,	PUNCT
ecletica-285	307	16	canada	canada	PROPN
ecletica-285	307	17	,	,	PUNCT
ecletica-285	307	18	1995	1995	NUM
ecletica-285	307	19	.	.	PUNCT
ecletica-285	308	1	[	[	X
ecletica-285	308	2	28	28	NUM
ecletica-285	308	3	]	]	X
ecletica-285	308	4	schrödinger	schrödinger	PROPN
ecletica-285	308	5	,	,	PUNCT
ecletica-285	308	6	inc	inc	PROPN
ecletica-285	308	7	.	.	PROPN
ecletica-285	308	8	first	first	PROPN
ecletica-285	308	9	discovery	discovery	PROPN
ecletica-285	308	10	:	:	PUNCT
ecletica-285	308	11	technical	technical	ADJ
ecletica-285	308	12	notes	note	NOUN
ecletica-285	308	13	for	for	ADP
ecletica-285	308	14	version	version	NOUN
ecletica-285	308	15	1.8	1.8	NUM
ecletica-285	308	16	.	.	PUNCT
ecletica-285	309	1	portland	portland	PROPN
ecletica-285	309	2	,	,	PUNCT
ecletica-285	309	3	usa	usa	PROPN
ecletica-285	309	4	,	,	PUNCT
ecletica-285	309	5	2001	2001	NUM
ecletica-285	309	6	.	.	PUNCT
ecletica-285	310	1	[	[	X
ecletica-285	310	2	29	29	NUM
ecletica-285	310	3	]	]	X
ecletica-285	310	4	stewart	stewart	PROPN
ecletica-285	310	5	,	,	PUNCT
ecletica-285	310	6	j.j.p	j.j.p	PROPN
ecletica-285	310	7	.	.	PUNCT
ecletica-285	311	1	j.	j.	PROPN
ecletica-285	311	2	comput	comput	PROPN
ecletica-285	311	3	.	.	PUNCT
ecletica-285	312	1	chem	chem	NOUN
ecletica-285	312	2	.	.	PUNCT
ecletica-285	313	1	10	10	NUM
ecletica-285	313	2	(	(	PUNCT
ecletica-285	313	3	1989	1989	NUM
ecletica-285	313	4	)	)	PUNCT
ecletica-285	313	5	209	209	NUM
ecletica-285	313	6	.	.	PUNCT
ecletica-285	314	1	[	[	X
ecletica-285	314	2	30	30	NUM
ecletica-285	314	3	]	]	X
ecletica-285	314	4	cole	cole	PROPN
ecletica-285	314	5	,	,	PUNCT
ecletica-285	314	6	c.	c.	PROPN
ecletica-285	314	7	;	;	PUNCT
ecletica-285	314	8	warwicker	warwicker	PROPN
ecletica-285	314	9	,	,	PUNCT
ecletica-285	314	10	j.	j.	PROPN
ecletica-285	314	11	protein	protein	NOUN
ecletica-285	314	12	science	science	PROPN
ecletica-285	314	13	11	11	NUM
ecletica-285	314	14	(	(	PUNCT
ecletica-285	314	15	2002	2002	NUM
ecletica-285	314	16	)	)	PUNCT
ecletica-285	314	17	2860	2860	NUM
ecletica-285	314	18	.	.	PUNCT
ecletica-285	315	1	[	[	X
ecletica-285	315	2	31	31	NUM
ecletica-285	315	3	]	]	X
ecletica-285	315	4	bodor	bodor	NOUN
ecletica-285	315	5	,	,	PUNCT
ecletica-285	315	6	n.	n.	NOUN
ecletica-285	315	7	,	,	PUNCT
ecletica-285	315	8	gabanyi	gabanyi	PROPN
ecletica-285	315	9	,	,	PUNCT
ecletica-285	315	10	c.	c.	PROPN
ecletica-285	315	11	,	,	PUNCT
ecletica-285	315	12	wong	wong	PROPN
ecletica-285	315	13	,	,	PUNCT
ecletica-285	315	14	j.	j.	PROPN
ecletica-285	315	15	j.	j.	PROPN
ecletica-285	315	16	am	am	PROPN
ecletica-285	315	17	.	.	PUNCT
ecletica-285	315	18	chem	chem	PROPN
ecletica-285	315	19	.	.	PUNCT
ecletica-285	315	20	soc	soc	PROPN
ecletica-285	315	21	.	.	PUNCT
ecletica-285	316	1	111	111	NUM
ecletica-285	316	2	(	(	PUNCT
ecletica-285	316	3	1989	1989	NUM
ecletica-285	316	4	)	)	PUNCT
ecletica-285	316	5	3783	3783	NUM
ecletica-285	316	6	.	.	PUNCT
ecletica-285	317	1	[	[	X
ecletica-285	317	2	32	32	NUM
ecletica-285	317	3	]	]	X
ecletica-285	317	4	gavezotti	gavezotti	PROPN
ecletica-285	317	5	,	,	PUNCT
ecletica-285	317	6	a.	a.	PROPN
ecletica-285	317	7	j.	j.	PROPN
ecletica-285	317	8	am	am	PROPN
ecletica-285	317	9	.	.	PUNCT
ecletica-285	318	1	chem	chem	NOUN
ecletica-285	318	2	.	.	PUNCT
ecletica-285	319	1	soc	soc	PROPN
ecletica-285	319	2	.	.	PUNCT
ecletica-285	320	1	100	100	NUM
ecletica-285	320	2	(	(	PUNCT
ecletica-285	320	3	1983	1983	NUM
ecletica-285	320	4	)	)	PUNCT
ecletica-285	320	5	5520	5520	NUM
ecletica-285	320	6	.	.	PUNCT
ecletica-285	321	1	ecl	ecl	PROPN
ecletica-285	321	2	.	.	PROPN
ecletica-285	321	3	quím	quím	PROPN
ecletica-285	321	4	.	.	PUNCT
ecletica-285	321	5	,	,	PUNCT
ecletica-285	321	6	são	são	PROPN
ecletica-285	321	7	paulo	paulo	PROPN
ecletica-285	321	8	,	,	PUNCT
ecletica-285	321	9	34(4	34(4	NUM
ecletica-285	321	10	):	):	PUNCT
ecletica-285	321	11	87	87	NUM
ecletica-285	321	12	102	102	NUM
ecletica-285	321	13	,	,	PUNCT
ecletica-285	321	14	2009102	2009102	NUM
ecletica-285	321	15	artigo	artigo	NOUN
ecletica-285	321	16	article	article	NOUN
ecletica-285	321	17	[	[	X
ecletica-285	321	18	33	33	NUM
ecletica-285	321	19	]	]	X
ecletica-285	321	20	hupercube	hupercube	PROPN
ecletica-285	321	21	inc	inc	PROPN
ecletica-285	321	22	.	.	PROPN
ecletica-285	321	23	,	,	PUNCT
ecletica-285	321	24	chemplus	chemplus	PROPN
ecletica-285	321	25	:	:	PUNCT
ecletica-285	321	26	extentions	extention	NOUN
ecletica-285	321	27	for	for	ADP
ecletica-285	321	28	hyperchem	hyperchem	NOUN
ecletica-285	321	29	,	,	PUNCT
ecletica-285	321	30	hypercube	hypercube	PROPN
ecletica-285	321	31	inc	inc	PROPN
ecletica-285	321	32	.	.	PROPN
ecletica-285	321	33	,	,	PUNCT
ecletica-285	321	34	waterloo	waterloo	PROPN
ecletica-285	321	35	,	,	PUNCT
ecletica-285	321	36	canada	canada	PROPN
ecletica-285	321	37	,	,	PUNCT
ecletica-285	321	38	1993	1993	NUM
ecletica-285	321	39	.	.	PUNCT
ecletica-285	322	1	[	[	X
ecletica-285	322	2	34	34	NUM
ecletica-285	322	3	]	]	X
ecletica-285	322	4	leite	leite	PROPN
ecletica-285	322	5	,	,	PUNCT
ecletica-285	322	6	s.r.a	s.r.a	PROPN
ecletica-285	322	7	.	.	PUNCT
ecletica-285	322	8	eclet	eclet	PROPN
ecletica-285	322	9	.	.	PUNCT
ecletica-285	323	1	quím	quím	PROPN
ecletica-285	323	2	.	.	PUNCT
ecletica-285	324	1	33	33	NUM
ecletica-285	324	2	(	(	PUNCT
ecletica-285	324	3	2008	2008	NUM
ecletica-285	324	4	)	)	PUNCT
ecletica-285	324	5	47	47	NUM
ecletica-285	324	6	.	.	PUNCT
ecletica-285	325	1	[	[	X
ecletica-285	325	2	35	35	NUM
ecletica-285	325	3	]	]	X
ecletica-285	325	4	jayaselli	jayaselli	PROPN
ecletica-285	325	5	,	,	PUNCT
ecletica-285	325	6	j.	j.	PROPN
ecletica-285	325	7	;	;	PUNCT
ecletica-285	325	8	cheemala	cheemala	PROPN
ecletica-285	325	9	,	,	PUNCT
ecletica-285	325	10	j.m.s	j.m.s	PROPN
ecletica-285	325	11	.	.	PUNCT
ecletica-285	325	12	;	;	PUNCT
ecletica-285	325	13	rani	rani	PROPN
ecletica-285	325	14	d.p.g	d.p.g	PROPN
ecletica-285	325	15	.	.	PROPN
ecletica-285	325	16	;	;	PUNCT
ecletica-285	325	17	pal	pal	NOUN
ecletica-285	325	18	,	,	PUNCT
ecletica-285	325	19	s.	s.	PROPN
ecletica-285	325	20	j.	j.	PROPN
ecletica-285	325	21	braz	braz	PROPN
ecletica-285	325	22	.	.	PUNCT
ecletica-285	325	23	chem	chem	PROPN
ecletica-285	325	24	.	.	PUNCT
ecletica-285	326	1	soc	soc	PROPN
ecletica-285	326	2	.	.	PUNCT
ecletica-285	327	1	19	19	NUM
ecletica-285	327	2	(	(	PUNCT
ecletica-285	327	3	2008	2008	NUM
ecletica-285	327	4	)	)	PUNCT
ecletica-285	327	5	509	509	NUM
ecletica-285	327	6	.	.	PUNCT
ecletica-285	328	1	[	[	X
ecletica-285	328	2	36	36	NUM
ecletica-285	328	3	]	]	X
ecletica-285	328	4	ingold	ingold	PROPN
ecletica-285	328	5	,	,	PUNCT
ecletica-285	328	6	c.	c.	PROPN
ecletica-285	328	7	k.	k.	PROPN
ecletica-285	328	8	structure	structure	PROPN
ecletica-285	328	9	and	and	CCONJ
ecletica-285	328	10	mechanism	mechanism	NOUN
ecletica-285	328	11	in	in	ADP
ecletica-285	328	12	organic	organic	ADJ
ecletica-285	328	13	chemistry	chemistry	NOUN
ecletica-285	328	14	;	;	PUNCT
ecletica-285	328	15	cornell	cornell	PROPN
ecletica-285	328	16	university	university	PROPN
ecletica-285	328	17	press	press	NOUN
ecletica-285	328	18	;	;	PUNCT
ecletica-285	328	19	ithaca	ithaca	PROPN
ecletica-285	328	20	,	,	PUNCT
ecletica-285	328	21	1953	1953	NUM
ecletica-285	328	22	.	.	PUNCT