id	sid	tid	token	lemma	pos
ecletica-329	1	1	eq06	eq06	PROPN
ecletica-329	1	2	-	-	PUNCT
ecletica-329	1	3	af	af	PROPN
ecletica-329	1	4	introduction	introduction	NOUN
ecletica-329	1	5	the	the	DET
ecletica-329	1	6	gas	gas	NOUN
ecletica-329	1	7	gangrene	gangrene	NOUN
ecletica-329	1	8	or	or	CCONJ
ecletica-329	1	9	myonecrosis	myonecrosis	NOUN
ecletica-329	1	10	is	be	AUX
ecletica-329	1	11	a	a	DET
ecletica-329	1	12	serious	serious	ADJ
ecletica-329	1	13	infectious	infectious	ADJ
ecletica-329	1	14	process	process	NOUN
ecletica-329	1	15	of	of	ADP
ecletica-329	1	16	fast	fast	ADJ
ecletica-329	1	17	evolution	evolution	NOUN
ecletica-329	1	18	,	,	PUNCT
ecletica-329	1	19	that	that	PRON
ecletica-329	1	20	may	may	AUX
ecletica-329	1	21	arises	arise	VERB
ecletica-329	1	22	from	from	ADP
ecletica-329	1	23	the	the	DET
ecletica-329	1	24	contamination	contamination	NOUN
ecletica-329	1	25	of	of	ADP
ecletica-329	1	26	wounds	wound	NOUN
ecletica-329	1	27	for	for	ADP
ecletica-329	1	28	its	its	PRON
ecletica-329	1	29	etiological	etiological	ADJ
ecletica-329	1	30	agents	agent	NOUN
ecletica-329	1	31	.	.	PUNCT
ecletica-329	2	1	although	although	SCONJ
ecletica-329	2	2	the	the	DET
ecletica-329	2	3	disease	disease	NOUN
ecletica-329	2	4	is	be	AUX
ecletica-329	2	5	known	know	VERB
ecletica-329	2	6	since	since	SCONJ
ecletica-329	2	7	remote	remote	ADJ
ecletica-329	2	8	times	time	NOUN
ecletica-329	2	9	,	,	PUNCT
ecletica-329	2	10	its	its	PRON
ecletica-329	2	11	etiology	etiology	NOUN
ecletica-329	2	12	was	be	AUX
ecletica-329	2	13	only	only	ADV
ecletica-329	2	14	defined	define	VERB
ecletica-329	2	15	in	in	ADP
ecletica-329	2	16	the	the	DET
ecletica-329	2	17	end	end	NOUN
ecletica-329	2	18	of	of	ADP
ecletica-329	2	19	the	the	DET
ecletica-329	2	20	xix	xix	PROPN
ecletica-329	2	21	century	century	NOUN
ecletica-329	2	22	,	,	PUNCT
ecletica-329	2	23	when	when	SCONJ
ecletica-329	2	24	gram	gram	NOUN
ecletica-329	2	25	-	-	PUNCT
ecletica-329	2	26	positive	positive	ADJ
ecletica-329	2	27	bacilli	bacilli	NOUN
ecletica-329	2	28	obligate	obligate	NOUN
ecletica-329	2	29	anaerobes	anaerobe	NOUN
ecletica-329	2	30	were	be	AUX
ecletica-329	2	31	isolated	isolate	VERB
ecletica-329	2	32	from	from	ADP
ecletica-329	2	33	infected	infected	ADJ
ecletica-329	2	34	wounds	wound	NOUN
ecletica-329	2	35	.	.	PUNCT
ecletica-329	3	1	initially	initially	ADV
ecletica-329	3	2	classified	classify	VERB
ecletica-329	3	3	under	under	ADP
ecletica-329	3	4	the	the	DET
ecletica-329	3	5	gender	gender	NOUN
ecletica-329	3	6	bacillus	bacillus	NOUN
ecletica-329	3	7	,	,	PUNCT
ecletica-329	3	8	were	be	AUX
ecletica-329	3	9	later	later	ADV
ecletica-329	3	10	included	include	VERB
ecletica-329	3	11	in	in	ADP
ecletica-329	3	12	the	the	DET
ecletica-329	3	13	gender	gender	NOUN
ecletica-329	3	14	clostridium	clostridium	NOUN
ecletica-329	3	15	.	.	PUNCT
ecletica-329	4	1	although	although	SCONJ
ecletica-329	4	2	the	the	DET
ecletica-329	4	3	species	specie	NOUN
ecletica-329	4	4	clostridium	clostridium	NOUN
ecletica-329	4	5	perfringens	perfringen	NOUN
ecletica-329	4	6	is	be	AUX
ecletica-329	4	7	more	more	ADV
ecletica-329	4	8	frequently	frequently	ADV
ecletica-329	4	9	isolated	isolate	VERB
ecletica-329	4	10	from	from	ADP
ecletica-329	4	11	gas	gas	NOUN
ecletica-329	4	12	gangrene	gangrene	NOUN
ecletica-329	4	13	lesions	lesion	NOUN
ecletica-329	4	14	,	,	PUNCT
ecletica-329	4	15	other	other	ADJ
ecletica-329	4	16	clostridium	clostridium	NOUN
ecletica-329	4	17	species	specie	NOUN
ecletica-329	4	18	also	also	ADV
ecletica-329	4	19	occur	occur	VERB
ecletica-329	4	20	as	as	ADP
ecletica-329	4	21	its	its	PRON
ecletica-329	4	22	etiological	etiological	ADJ
ecletica-329	4	23	agents	agent	NOUN
ecletica-329	4	24	,	,	PUNCT
ecletica-329	4	25	like	like	ADP
ecletica-329	4	26	c.	c.	PROPN
ecletica-329	4	27	histolyticum	histolyticum	PROPN
ecletica-329	4	28	,	,	PUNCT
ecletica-329	4	29	c.	c.	PROPN
ecletica-329	4	30	septicum	septicum	PROPN
ecletica-329	4	31	,	,	PUNCT
ecletica-329	4	32	c.	c.	PROPN
ecletica-329	4	33	sporogenes	sporogene	NOUN
ecletica-329	4	34	and	and	CCONJ
ecletica-329	4	35	c.	c.	NOUN
ecletica-329	4	36	bifermentans	bifermentan	NOUN
ecletica-329	4	37	.	.	PUNCT
ecletica-329	5	1	these	these	DET
ecletica-329	5	2	organisms	organism	NOUN
ecletica-329	5	3	,	,	PUNCT
ecletica-329	5	4	under	under	ADP
ecletica-329	5	5	appropriate	appropriate	ADJ
ecletica-329	5	6	conditions	condition	NOUN
ecletica-329	5	7	,	,	PUNCT
ecletica-329	5	8	namely	namely	ADV
ecletica-329	5	9	,	,	PUNCT
ecletica-329	5	10	low	low	ADJ
ecletica-329	5	11	partial	partial	ADJ
ecletica-329	5	12	tension	tension	NOUN
ecletica-329	5	13	of	of	ADP
ecletica-329	5	14	oxygen	oxygen	NOUN
ecletica-329	5	15	,	,	PUNCT
ecletica-329	5	16	multiply	multiply	VERB
ecletica-329	5	17	quickly	quickly	ADV
ecletica-329	5	18	and	and	CCONJ
ecletica-329	5	19	produce	produce	VERB
ecletica-329	5	20	a	a	DET
ecletica-329	5	21	series	series	NOUN
ecletica-329	5	22	of	of	ADP
ecletica-329	5	23	toxins	toxin	NOUN
ecletica-329	5	24	and	and	CCONJ
ecletica-329	5	25	hydrolytic	hydrolytic	ADJ
ecletica-329	5	26	enzymes	enzyme	NOUN
ecletica-329	5	27	,	,	PUNCT
ecletica-329	5	28	responsible	responsible	ADJ
ecletica-329	5	29	for	for	ADP
ecletica-329	5	30	the	the	DET
ecletica-329	5	31	pathogeny	pathogeny	NOUN
ecletica-329	5	32	and	and	CCONJ
ecletica-329	5	33	clinical	clinical	ADJ
ecletica-329	5	34	manifestations	manifestation	NOUN
ecletica-329	5	35	of	of	ADP
ecletica-329	5	36	the	the	DET
ecletica-329	5	37	process	process	NOUN
ecletica-329	5	38	.	.	PUNCT
ecletica-329	6	1	this	this	PRON
ecletica-329	6	2	it	it	PRON
ecletica-329	6	3	is	be	AUX
ecletica-329	6	4	characterized	characterize	VERB
ecletica-329	6	5	by	by	ADP
ecletica-329	6	6	extensive	extensive	ADJ
ecletica-329	6	7	necrosis	necrosis	NOUN
ecletica-329	6	8	of	of	ADP
ecletica-329	6	9	the	the	DET
ecletica-329	6	10	muscular	muscular	ADJ
ecletica-329	6	11	and	and	CCONJ
ecletica-329	6	12	conjunctive	conjunctive	ADJ
ecletica-329	6	13	tissues	tissue	NOUN
ecletica-329	6	14	starting	start	VERB
ecletica-329	6	15	in	in	ADP
ecletica-329	6	16	the	the	DET
ecletica-329	6	17	neighborhoods	neighborhood	NOUN
ecletica-329	6	18	of	of	ADP
ecletica-329	6	19	the	the	DET
ecletica-329	6	20	infected	infected	ADJ
ecletica-329	6	21	47ecl	47ecl	NOUN
ecletica-329	6	22	.	.	PUNCT
ecletica-329	7	1	quím	quím	PROPN
ecletica-329	7	2	.	.	PUNCT
ecletica-329	8	1	,	,	PUNCT
ecletica-329	8	2	são	são	PROPN
ecletica-329	8	3	paulo	paulo	PROPN
ecletica-329	8	4	,	,	PUNCT
ecletica-329	8	5	33(4	33(4	NUM
ecletica-329	8	6	):	):	PUNCT
ecletica-329	8	7	47	47	NUM
ecletica-329	8	8	-	-	SYM
ecletica-329	8	9	52	52	NUM
ecletica-329	8	10	,	,	PUNCT
ecletica-329	8	11	2008	2008	NUM
ecletica-329	8	12	www.scielo.br/eq	www.scielo.br/eq	NOUN
ecletica-329	8	13	www.ecletica.iq.unesp.br	www.ecletica.iq.unesp.br	ADJ
ecletica-329	8	14	volume	volume	NOUN
ecletica-329	8	15	33	33	NUM
ecletica-329	8	16	,	,	PUNCT
ecletica-329	8	17	número	número	NOUN
ecletica-329	8	18	4	4	NUM
ecletica-329	8	19	,	,	PUNCT
ecletica-329	8	20	2008	2008	NUM
ecletica-329	8	21	inhibitors	inhibitor	NOUN
ecletica-329	8	22	of	of	ADP
ecletica-329	8	23	clostridium	clostridium	NOUN
ecletica-329	8	24	histolyticum	histolyticum	NOUN
ecletica-329	8	25	colagenase	colagenase	PROPN
ecletica-329	8	26	s.	s.	PROPN
ecletica-329	8	27	r.	r.	PROPN
ecletica-329	8	28	a.	a.	PROPN
ecletica-329	8	29	leite	leite	PROPN
ecletica-329	8	30	*	*	PROPN
ecletica-329	8	31	instituto	instituto	PROPN
ecletica-329	8	32	de	de	PROPN
ecletica-329	8	33	química	química	PROPN
ecletica-329	8	34	,	,	PUNCT
ecletica-329	8	35	unesp	unesp	NOUN
ecletica-329	8	36	,	,	PUNCT
ecletica-329	8	37	cp	cp	PROPN
ecletica-329	8	38	355	355	NUM
ecletica-329	8	39	,	,	PUNCT
ecletica-329	8	40	14801	14801	NUM
ecletica-329	8	41	-	-	SYM
ecletica-329	8	42	970	970	NUM
ecletica-329	8	43	,	,	PUNCT
ecletica-329	8	44	araraquara	araraquara	NOUN
ecletica-329	8	45	,	,	PUNCT
ecletica-329	8	46	sp	sp	NOUN
ecletica-329	8	47	,	,	PUNCT
ecletica-329	8	48	brasil	brasil	NOUN
ecletica-329	8	49	*	*	PUNCT
ecletica-329	8	50	leite@iq.unesp.br	leite@iq.unesp.br	ADJ
ecletica-329	8	51	abstract	abstract	NOUN
ecletica-329	8	52	:	:	PUNCT
ecletica-329	8	53	different	different	ADJ
ecletica-329	8	54	substances	substance	NOUN
ecletica-329	8	55	were	be	AUX
ecletica-329	8	56	tested	test	VERB
ecletica-329	8	57	as	as	ADP
ecletica-329	8	58	inhibitors	inhibitor	NOUN
ecletica-329	8	59	of	of	ADP
ecletica-329	8	60	clostridium	clostridium	NOUN
ecletica-329	8	61	histolyticum	histolyticum	PROPN
ecletica-329	8	62	collagenase	collagenase	NOUN
ecletica-329	8	63	,	,	PUNCT
ecletica-329	8	64	both	both	CCONJ
ecletica-329	8	65	experimental	experimental	ADJ
ecletica-329	8	66	and	and	CCONJ
ecletica-329	8	67	theoretically	theoretically	ADV
ecletica-329	8	68	.	.	PUNCT
ecletica-329	9	1	the	the	DET
ecletica-329	9	2	in	in	ADP
ecletica-329	9	3	vitro	vitro	X
ecletica-329	9	4	collagenase	collagenase	NOUN
ecletica-329	9	5	activity	activity	NOUN
ecletica-329	9	6	,	,	PUNCT
ecletica-329	9	7	alone	alone	ADJ
ecletica-329	9	8	and	and	CCONJ
ecletica-329	9	9	in	in	ADP
ecletica-329	9	10	the	the	DET
ecletica-329	9	11	presence	presence	NOUN
ecletica-329	9	12	of	of	ADP
ecletica-329	9	13	inhibitors	inhibitor	NOUN
ecletica-329	9	14	,	,	PUNCT
ecletica-329	9	15	was	be	AUX
ecletica-329	9	16	quantified	quantify	VERB
ecletica-329	9	17	by	by	ADP
ecletica-329	9	18	reaction	reaction	NOUN
ecletica-329	9	19	with	with	ADP
ecletica-329	9	20	bovine	bovine	ADJ
ecletica-329	9	21	collagen	collagen	NOUN
ecletica-329	9	22	and	and	CCONJ
ecletica-329	9	23	dosage	dosage	NOUN
ecletica-329	9	24	of	of	ADP
ecletica-329	9	25	the	the	DET
ecletica-329	9	26	releasing	release	VERB
ecletica-329	9	27	amino	amino	NOUN
ecletica-329	9	28	acids	acid	NOUN
ecletica-329	9	29	.	.	PUNCT
ecletica-329	10	1	collagenaseinhibitor	collagenaseinhibitor	NOUN
ecletica-329	10	2	interaction	interaction	NOUN
ecletica-329	10	3	was	be	AUX
ecletica-329	10	4	studied	study	VERB
ecletica-329	10	5	theoretically	theoretically	ADV
ecletica-329	10	6	by	by	ADP
ecletica-329	10	7	docking	dock	VERB
ecletica-329	10	8	computational	computational	ADJ
ecletica-329	10	9	calculations	calculation	NOUN
ecletica-329	10	10	.	.	PUNCT
ecletica-329	11	1	only	only	ADV
ecletica-329	11	2	one	one	NUM
ecletica-329	11	3	among	among	ADP
ecletica-329	11	4	the	the	DET
ecletica-329	11	5	tested	test	VERB
ecletica-329	11	6	substances	substance	NOUN
ecletica-329	11	7	showed	show	VERB
ecletica-329	11	8	inhibitor	inhibitor	NOUN
ecletica-329	11	9	activity	activity	NOUN
ecletica-329	11	10	against	against	ADP
ecletica-329	11	11	the	the	DET
ecletica-329	11	12	bacterial	bacterial	ADJ
ecletica-329	11	13	collagenase	collagenase	NOUN
ecletica-329	11	14	.	.	PUNCT
ecletica-329	12	1	keywords	keyword	NOUN
ecletica-329	12	2	:	:	PUNCT
ecletica-329	12	3	clostridium	clostridium	NOUN
ecletica-329	12	4	histolyticum	histolyticum	NOUN
ecletica-329	12	5	;	;	PUNCT
ecletica-329	12	6	collagenase	collagenase	NOUN
ecletica-329	12	7	;	;	PUNCT
ecletica-329	12	8	inhibitors	inhibitor	NOUN
ecletica-329	12	9	;	;	PUNCT
ecletica-329	12	10	docking	dock	VERB
ecletica-329	12	11	.	.	PUNCT
ecletica-329	13	1	wound	wound	NOUN
ecletica-329	13	2	,	,	PUNCT
ecletica-329	13	3	and	and	CCONJ
ecletica-329	13	4	by	by	ADP
ecletica-329	13	5	systemic	systemic	ADJ
ecletica-329	13	6	manifestations	manifestation	NOUN
ecletica-329	13	7	,	,	PUNCT
ecletica-329	13	8	that	that	PRON
ecletica-329	13	9	increase	increase	VERB
ecletica-329	13	10	with	with	ADP
ecletica-329	13	11	the	the	DET
ecletica-329	13	12	development	development	NOUN
ecletica-329	13	13	of	of	ADP
ecletica-329	13	14	the	the	DET
ecletica-329	13	15	process	process	NOUN
ecletica-329	13	16	.	.	PUNCT
ecletica-329	14	1	the	the	DET
ecletica-329	14	2	primary	primary	ADJ
ecletica-329	14	3	cause	cause	NOUN
ecletica-329	14	4	of	of	ADP
ecletica-329	14	5	the	the	DET
ecletica-329	14	6	necrosis	necrosis	NOUN
ecletica-329	14	7	is	be	AUX
ecletica-329	14	8	the	the	DET
ecletica-329	14	9	lysis	lysis	NOUN
ecletica-329	14	10	of	of	ADP
ecletica-329	14	11	the	the	DET
ecletica-329	14	12	tissue	tissue	NOUN
ecletica-329	14	13	structures	structure	NOUN
ecletica-329	14	14	by	by	ADP
ecletica-329	14	15	lytic	lytic	ADJ
ecletica-329	14	16	enzymes	enzyme	NOUN
ecletica-329	14	17	,	,	PUNCT
ecletica-329	14	18	e.g.	e.g.	ADV
ecletica-329	14	19	,	,	PUNCT
ecletica-329	14	20	lecitinase	lecitinase	NOUN
ecletica-329	14	21	,	,	PUNCT
ecletica-329	14	22	hyaluronidase	hyaluronidase	ADV
ecletica-329	14	23	,	,	PUNCT
ecletica-329	14	24	desoxi	desoxi	ADJ
ecletica-329	14	25	-	-	PUNCT
ecletica-329	14	26	ribonuclease	ribonuclease	NOUN
ecletica-329	14	27	and	and	CCONJ
ecletica-329	14	28	several	several	ADJ
ecletica-329	14	29	proteases	protease	NOUN
ecletica-329	14	30	,	,	PUNCT
ecletica-329	14	31	as	as	ADP
ecletica-329	14	32	gelatinase	gelatinase	NOUN
ecletica-329	14	33	and	and	CCONJ
ecletica-329	14	34	collagenase	collagenase	NOUN
ecletica-329	14	35	,	,	PUNCT
ecletica-329	14	36	with	with	ADP
ecletica-329	14	37	prominence	prominence	NOUN
ecletica-329	14	38	for	for	ADP
ecletica-329	14	39	this	this	DET
ecletica-329	14	40	last	last	ADJ
ecletica-329	14	41	one	one	NOUN
ecletica-329	14	42	,	,	PUNCT
ecletica-329	14	43	as	as	ADP
ecletica-329	14	44	one	one	NUM
ecletica-329	14	45	of	of	ADP
ecletica-329	14	46	the	the	DET
ecletica-329	14	47	main	main	ADJ
ecletica-329	14	48	responsible	responsible	ADJ
ecletica-329	14	49	for	for	ADP
ecletica-329	14	50	the	the	DET
ecletica-329	14	51	destruction	destruction	NOUN
ecletica-329	14	52	of	of	ADP
ecletica-329	14	53	conjunctive	conjunctive	ADJ
ecletica-329	14	54	,	,	PUNCT
ecletica-329	14	55	muscular	muscular	ADJ
ecletica-329	14	56	and	and	CCONJ
ecletica-329	14	57	vascular	vascular	ADJ
ecletica-329	14	58	tissues	tissue	NOUN
ecletica-329	14	59	.	.	PUNCT
ecletica-329	15	1	this	this	DET
ecletica-329	15	2	collagenase	collagenase	NOUN
ecletica-329	15	3	is	be	AUX
ecletica-329	15	4	obtained	obtain	VERB
ecletica-329	15	5	commercially	commercially	ADV
ecletica-329	15	6	from	from	ADP
ecletica-329	15	7	cultures	culture	NOUN
ecletica-329	15	8	of	of	ADP
ecletica-329	15	9	clostridium	clostridium	NOUN
ecletica-329	15	10	histolyticum	histolyticum	NOUN
ecletica-329	15	11	.	.	PUNCT
ecletica-329	16	1	this	this	PRON
ecletica-329	16	2	is	be	AUX
ecletica-329	16	3	the	the	DET
ecletica-329	16	4	enzyme	enzyme	NOUN
ecletica-329	16	5	with	with	ADP
ecletica-329	16	6	collagenolitic	collagenolitic	ADJ
ecletica-329	16	7	activity	activity	NOUN
ecletica-329	16	8	more	more	ADV
ecletica-329	16	9	used	use	VERB
ecletica-329	16	10	in	in	ADP
ecletica-329	16	11	practice	practice	NOUN
ecletica-329	16	12	,	,	PUNCT
ecletica-329	16	13	for	for	ADP
ecletica-329	16	14	example	example	NOUN
ecletica-329	16	15	,	,	PUNCT
ecletica-329	16	16	in	in	ADP
ecletica-329	16	17	the	the	DET
ecletica-329	16	18	separation	separation	NOUN
ecletica-329	16	19	of	of	ADP
ecletica-329	16	20	cells	cell	NOUN
ecletica-329	16	21	and	and	CCONJ
ecletica-329	16	22	in	in	ADP
ecletica-329	16	23	dermatological	dermatological	ADJ
ecletica-329	16	24	products	product	NOUN
ecletica-329	16	25	.	.	PUNCT
ecletica-329	17	1	in	in	ADP
ecletica-329	17	2	the	the	DET
ecletica-329	17	3	present	present	ADJ
ecletica-329	17	4	work	work	NOUN
ecletica-329	17	5	we	we	PRON
ecletica-329	17	6	intended	intend	VERB
ecletica-329	17	7	to	to	PART
ecletica-329	17	8	study	study	VERB
ecletica-329	17	9	inhibitors	inhibitor	NOUN
ecletica-329	17	10	of	of	ADP
ecletica-329	17	11	the	the	DET
ecletica-329	17	12	collagenase	collagenase	NOUN
ecletica-329	17	13	of	of	ADP
ecletica-329	17	14	c.	c.	PROPN
ecletica-329	17	15	histolyticum	histolyticum	PROPN
ecletica-329	17	16	.	.	PUNCT
ecletica-329	18	1	inhibitors	inhibitor	NOUN
ecletica-329	18	2	of	of	ADP
ecletica-329	18	3	this	this	DET
ecletica-329	18	4	enzyme	enzyme	NOUN
ecletica-329	18	5	should	should	AUX
ecletica-329	18	6	be	be	AUX
ecletica-329	18	7	used	use	VERB
ecletica-329	18	8	as	as	ADP
ecletica-329	18	9	auxiliary	auxiliary	ADJ
ecletica-329	18	10	drugs	drug	NOUN
ecletica-329	18	11	for	for	ADP
ecletica-329	18	12	treatment	treatment	NOUN
ecletica-329	18	13	of	of	ADP
ecletica-329	18	14	gas	gas	NOUN
ecletica-329	18	15	gangrene	gangrene	NOUN
ecletica-329	18	16	.	.	PUNCT
ecletica-329	19	1	the	the	DET
ecletica-329	19	2	work	work	NOUN
ecletica-329	19	3	consisted	consist	VERB
ecletica-329	19	4	of	of	ADP
ecletica-329	19	5	an	an	DET
ecletica-329	19	6	experimental	experimental	ADJ
ecletica-329	19	7	part	part	NOUN
ecletica-329	19	8	,	,	PUNCT
ecletica-329	19	9	in	in	ADP
ecletica-329	19	10	which	which	PRON
ecletica-329	19	11	the	the	DET
ecletica-329	19	12	effect	effect	NOUN
ecletica-329	19	13	of	of	ADP
ecletica-329	19	14	different	different	ADJ
ecletica-329	19	15	substances	substance	NOUN
ecletica-329	19	16	was	be	AUX
ecletica-329	19	17	verified	verify	VERB
ecletica-329	19	18	on	on	ADP
ecletica-329	19	19	collagenase	collagenase	NOUN
ecletica-329	19	20	of	of	ADP
ecletica-329	19	21	c.	c.	PROPN
ecletica-329	19	22	histolyticum	histolyticum	PROPN
ecletica-329	19	23	,	,	PUNCT
ecletica-329	19	24	and	and	CCONJ
ecletica-329	19	25	of	of	ADP
ecletica-329	19	26	a	a	DET
ecletica-329	19	27	theoretical	theoretical	ADJ
ecletica-329	19	28	part	part	NOUN
ecletica-329	19	29	,	,	PUNCT
ecletica-329	19	30	in	in	ADP
ecletica-329	19	31	which	which	PRON
ecletica-329	19	32	the	the	DET
ecletica-329	19	33	simulation	simulation	NOUN
ecletica-329	19	34	of	of	ADP
ecletica-329	19	35	the	the	DET
ecletica-329	19	36	structures	structure	NOUN
ecletica-329	19	37	of	of	ADP
ecletica-329	19	38	these	these	DET
ecletica-329	19	39	substances	substance	NOUN
ecletica-329	19	40	and	and	CCONJ
ecletica-329	19	41	their	their	PRON
ecletica-329	19	42	interaction	interaction	NOUN
ecletica-329	19	43	with	with	ADP
ecletica-329	19	44	the	the	DET
ecletica-329	19	45	collagenase	collagenase	NOUN
ecletica-329	19	46	were	be	AUX
ecletica-329	19	47	performed	perform	VERB
ecletica-329	19	48	.	.	PUNCT
ecletica-329	20	1	eq06	eq06	PROPN
ecletica-329	20	2	-	-	PUNCT
ecletica-329	20	3	af	af	PROPN
ecletica-329	20	4	4/12/08	4/12/08	NUM
ecletica-329	20	5	9:55	9:55	NUM
ecletica-329	20	6	page	page	NOUN
ecletica-329	20	7	47	47	NUM
ecletica-329	20	8	experimental	experimental	ADJ
ecletica-329	20	9	the	the	DET
ecletica-329	20	10	collagenase	collagenase	NOUN
ecletica-329	20	11	activity	activity	NOUN
ecletica-329	20	12	was	be	AUX
ecletica-329	20	13	measured	measure	VERB
ecletica-329	20	14	by	by	ADP
ecletica-329	20	15	collagen	collagen	NOUN
ecletica-329	20	16	hydrolysis	hydrolysis	NOUN
ecletica-329	20	17	and	and	CCONJ
ecletica-329	20	18	determination	determination	NOUN
ecletica-329	20	19	of	of	ADP
ecletica-329	20	20	the	the	DET
ecletica-329	20	21	released	release	VERB
ecletica-329	20	22	amino	amino	NOUN
ecletica-329	20	23	acids	acid	NOUN
ecletica-329	20	24	.	.	PUNCT
ecletica-329	21	1	the	the	DET
ecletica-329	21	2	method	method	NOUN
ecletica-329	21	3	was	be	AUX
ecletica-329	21	4	adapted	adapt	VERB
ecletica-329	21	5	from	from	ADP
ecletica-329	21	6	mandl	mandl	PROPN
ecletica-329	21	7	et	et	PROPN
ecletica-329	21	8	al	al	PROPN
ecletica-329	22	1	[	[	X
ecletica-329	22	2	1	1	NUM
ecletica-329	22	3	]	]	PUNCT
ecletica-329	22	4	,	,	PUNCT
ecletica-329	22	5	in	in	ADP
ecletica-329	22	6	which	which	PRON
ecletica-329	22	7	native	native	ADJ
ecletica-329	22	8	collagen	collagen	NOUN
ecletica-329	22	9	is	be	AUX
ecletica-329	22	10	incubated	incubate	VERB
ecletica-329	22	11	for	for	ADP
ecletica-329	22	12	5	5	NUM
ecletica-329	22	13	hours	hour	NOUN
ecletica-329	22	14	with	with	ADP
ecletica-329	22	15	collagenase	collagenase	NOUN
ecletica-329	22	16	and	and	CCONJ
ecletica-329	22	17	the	the	DET
ecletica-329	22	18	amino	amino	NOUN
ecletica-329	22	19	acids	acid	NOUN
ecletica-329	22	20	are	be	AUX
ecletica-329	22	21	colorimetrically	colorimetrically	ADV
ecletica-329	22	22	determined	determine	VERB
ecletica-329	22	23	by	by	ADP
ecletica-329	22	24	reaction	reaction	NOUN
ecletica-329	22	25	with	with	ADP
ecletica-329	22	26	ninhydrine	ninhydrine	NOUN
ecletica-329	23	1	[	[	X
ecletica-329	23	2	2	2	NUM
ecletica-329	23	3	]	]	PUNCT
ecletica-329	23	4	.	.	PUNCT
ecletica-329	24	1	the	the	DET
ecletica-329	24	2	reaction	reaction	NOUN
ecletica-329	24	3	medium	medium	NOUN
ecletica-329	24	4	was	be	AUX
ecletica-329	24	5	buffered	buffer	VERB
ecletica-329	24	6	to	to	ADP
ecletica-329	24	7	ph	ph	PROPN
ecletica-329	24	8	7,5	7,5	NUM
ecletica-329	24	9	with	with	ADP
ecletica-329	24	10	tricine	tricine	NOUN
ecletica-329	24	11	50	50	NUM
ecletica-329	24	12	mm	mm	NOUN
ecletica-329	24	13	added	add	VERB
ecletica-329	24	14	of	of	ADP
ecletica-329	24	15	0,4	0,4	NUM
ecletica-329	24	16	m	m	NOUN
ecletica-329	24	17	nacl	nacl	ADJ
ecletica-329	24	18	.	.	PUNCT
ecletica-329	25	1	for	for	ADP
ecletica-329	25	2	the	the	DET
ecletica-329	25	3	inhibition	inhibition	NOUN
ecletica-329	25	4	trials	trial	NOUN
ecletica-329	25	5	,	,	PUNCT
ecletica-329	25	6	the	the	DET
ecletica-329	25	7	ligands	ligand	NOUN
ecletica-329	25	8	were	be	AUX
ecletica-329	25	9	mixed	mix	VERB
ecletica-329	25	10	to	to	ADP
ecletica-329	25	11	the	the	DET
ecletica-329	25	12	enzyme	enzyme	NOUN
ecletica-329	25	13	one	one	NUM
ecletica-329	25	14	hour	hour	NOUN
ecletica-329	25	15	before	before	ADP
ecletica-329	25	16	the	the	DET
ecletica-329	25	17	beginning	beginning	NOUN
ecletica-329	25	18	of	of	ADP
ecletica-329	25	19	the	the	DET
ecletica-329	25	20	reaction	reaction	NOUN
ecletica-329	25	21	.	.	PUNCT
ecletica-329	26	1	the	the	DET
ecletica-329	26	2	choice	choice	NOUN
ecletica-329	26	3	of	of	ADP
ecletica-329	26	4	substances	substance	NOUN
ecletica-329	26	5	for	for	ADP
ecletica-329	26	6	test	test	NOUN
ecletica-329	26	7	was	be	AUX
ecletica-329	26	8	made	make	VERB
ecletica-329	26	9	in	in	ADP
ecletica-329	26	10	function	function	NOUN
ecletica-329	26	11	of	of	ADP
ecletica-329	26	12	reports	report	NOUN
ecletica-329	26	13	in	in	ADP
ecletica-329	26	14	the	the	DET
ecletica-329	26	15	literature	literature	NOUN
ecletica-329	26	16	(	(	PUNCT
ecletica-329	26	17	experimental	experimental	ADJ
ecletica-329	26	18	or	or	CCONJ
ecletica-329	26	19	clinical	clinical	ADJ
ecletica-329	26	20	)	)	PUNCT
ecletica-329	26	21	among	among	ADP
ecletica-329	26	22	common	common	ADJ
ecletica-329	26	23	drugs	drug	NOUN
ecletica-329	26	24	with	with	ADP
ecletica-329	26	25	inhibiting	inhibit	VERB
ecletica-329	26	26	effect	effect	NOUN
ecletica-329	26	27	upon	upon	SCONJ
ecletica-329	26	28	collagenases	collagenase	NOUN
ecletica-329	26	29	.	.	PUNCT
ecletica-329	27	1	the	the	DET
ecletica-329	27	2	selected	select	VERB
ecletica-329	27	3	drugs	drug	NOUN
ecletica-329	27	4	have	have	VERB
ecletica-329	27	5	different	different	ADJ
ecletica-329	27	6	structures	structure	NOUN
ecletica-329	27	7	and	and	CCONJ
ecletica-329	27	8	pharmacological	pharmacological	ADJ
ecletica-329	27	9	activities	activity	NOUN
ecletica-329	27	10	,	,	PUNCT
ecletica-329	27	11	but	but	CCONJ
ecletica-329	27	12	all	all	PRON
ecletica-329	27	13	share	share	VERB
ecletica-329	27	14	such	such	ADJ
ecletica-329	27	15	inhibiting	inhibit	VERB
ecletica-329	27	16	effect	effect	NOUN
ecletica-329	28	1	[	[	X
ecletica-329	28	2	3	3	NUM
ecletica-329	28	3	-	-	SYM
ecletica-329	28	4	9	9	NUM
ecletica-329	28	5	]	]	PUNCT
ecletica-329	28	6	.	.	PUNCT
ecletica-329	29	1	six	six	NUM
ecletica-329	29	2	ligands	ligand	NOUN
ecletica-329	29	3	were	be	AUX
ecletica-329	29	4	tested	test	VERB
ecletica-329	29	5	:	:	PUNCT
ecletica-329	29	6	three	three	NUM
ecletica-329	29	7	oxicans	oxican	NOUN
ecletica-329	29	8	,	,	PUNCT
ecletica-329	29	9	namely	namely	ADV
ecletica-329	29	10	meloxicam	meloxicam	NOUN
ecletica-329	29	11	,	,	PUNCT
ecletica-329	29	12	tenoxicam	tenoxicam	NOUN
ecletica-329	29	13	and	and	CCONJ
ecletica-329	29	14	piroxicam	piroxicam	ADJ
ecletica-329	29	15	,	,	PUNCT
ecletica-329	29	16	tetracycline	tetracycline	NOUN
ecletica-329	29	17	,	,	PUNCT
ecletica-329	29	18	doxycycline	doxycycline	NOUN
ecletica-329	29	19	and	and	CCONJ
ecletica-329	29	20	sodium	sodium	NOUN
ecletica-329	29	21	alendronate	alendronate	NOUN
ecletica-329	29	22	.	.	PUNCT
ecletica-329	30	1	the	the	DET
ecletica-329	30	2	inhibition	inhibition	NOUN
ecletica-329	30	3	constant	constant	ADJ
ecletica-329	30	4	was	be	AUX
ecletica-329	30	5	determined	determine	VERB
ecletica-329	30	6	for	for	ADP
ecletica-329	30	7	those	those	PRON
ecletica-329	30	8	that	that	PRON
ecletica-329	30	9	exhibited	exhibit	VERB
ecletica-329	30	10	activity	activity	NOUN
ecletica-329	30	11	against	against	ADP
ecletica-329	30	12	the	the	DET
ecletica-329	30	13	enzyme	enzyme	NOUN
ecletica-329	30	14	.	.	PUNCT
ecletica-329	31	1	c.	c.	PROPN
ecletica-329	31	2	histolyticum	histolyticum	PROPN
ecletica-329	31	3	collagenase	collagenase	PROPN
ecletica-329	31	4	(	(	PUNCT
ecletica-329	31	5	type	type	PROPN
ecletica-329	31	6	ia	ia	PROPN
ecletica-329	31	7	)	)	PUNCT
ecletica-329	31	8	was	be	AUX
ecletica-329	31	9	obtained	obtain	VERB
ecletica-329	31	10	from	from	ADP
ecletica-329	31	11	sigma	sigma	PROPN
ecletica-329	31	12	,	,	PUNCT
ecletica-329	31	13	st	st	PROPN
ecletica-329	31	14	.	.	PROPN
ecletica-329	31	15	louis	louis	PROPN
ecletica-329	31	16	,	,	PUNCT
ecletica-329	31	17	mo	mo	PROPN
ecletica-329	31	18	,	,	PUNCT
ecletica-329	31	19	usa	usa	PROPN
ecletica-329	31	20	.	.	PUNCT
ecletica-329	32	1	the	the	DET
ecletica-329	32	2	drugs	drug	NOUN
ecletica-329	32	3	(	(	PUNCT
ecletica-329	32	4	ligands	ligand	NOUN
ecletica-329	32	5	)	)	PUNCT
ecletica-329	32	6	were	be	AUX
ecletica-329	32	7	bought	buy	VERB
ecletica-329	32	8	from	from	ADP
ecletica-329	32	9	purifarma	purifarma	PROPN
ecletica-329	32	10	,	,	PUNCT
ecletica-329	32	11	são	são	PROPN
ecletica-329	32	12	paulo	paulo	PROPN
ecletica-329	32	13	,	,	PUNCT
ecletica-329	32	14	sp	sp	NOUN
ecletica-329	32	15	,	,	PUNCT
ecletica-329	32	16	brazil	brazil	PROPN
ecletica-329	32	17	.	.	PUNCT
ecletica-329	33	1	the	the	DET
ecletica-329	33	2	bovine	bovine	PROPN
ecletica-329	33	3	collagen	collagen	NOUN
ecletica-329	33	4	was	be	AUX
ecletica-329	33	5	produced	produce	VERB
ecletica-329	33	6	by	by	ADP
ecletica-329	33	7	gelita	gelita	PROPN
ecletica-329	33	8	south	south	PROPN
ecletica-329	33	9	america	america	PROPN
ecletica-329	33	10	,	,	PUNCT
ecletica-329	33	11	maringá	maringá	PROPN
ecletica-329	33	12	,	,	PUNCT
ecletica-329	33	13	pr	pr	NOUN
ecletica-329	33	14	,	,	PUNCT
ecletica-329	33	15	brazil	brazil	PROPN
ecletica-329	33	16	.	.	PUNCT
ecletica-329	34	1	the	the	DET
ecletica-329	34	2	computational	computational	ADJ
ecletica-329	34	3	calculations	calculation	NOUN
ecletica-329	34	4	comprise	comprise	VERB
ecletica-329	34	5	the	the	DET
ecletica-329	34	6	determination	determination	NOUN
ecletica-329	34	7	of	of	ADP
ecletica-329	34	8	the	the	DET
ecletica-329	34	9	three	three	NUM
ecletica-329	34	10	-	-	PUNCT
ecletica-329	34	11	dimensional	dimensional	ADJ
ecletica-329	34	12	structure	structure	NOUN
ecletica-329	34	13	of	of	ADP
ecletica-329	34	14	the	the	DET
ecletica-329	34	15	ligands	ligand	NOUN
ecletica-329	34	16	by	by	ADP
ecletica-329	34	17	energy	energy	NOUN
ecletica-329	34	18	minimization	minimization	NOUN
ecletica-329	34	19	methods	method	NOUN
ecletica-329	34	20	,	,	PUNCT
ecletica-329	34	21	and	and	CCONJ
ecletica-329	34	22	the	the	DET
ecletica-329	34	23	simulation	simulation	NOUN
ecletica-329	34	24	of	of	ADP
ecletica-329	34	25	the	the	DET
ecletica-329	34	26	interaction	interaction	NOUN
ecletica-329	34	27	between	between	ADP
ecletica-329	34	28	ligands	ligand	NOUN
ecletica-329	34	29	and	and	CCONJ
ecletica-329	34	30	collagenase	collagenase	ADJ
ecletica-329	34	31	active	active	ADJ
ecletica-329	34	32	site	site	NOUN
ecletica-329	34	33	by	by	ADP
ecletica-329	34	34	a	a	DET
ecletica-329	34	35	docking	docking	NOUN
ecletica-329	34	36	procedure	procedure	NOUN
ecletica-329	34	37	.	.	PUNCT
ecletica-329	35	1	the	the	DET
ecletica-329	35	2	enzyme	enzyme	NOUN
ecletica-329	35	3	structure	structure	NOUN
ecletica-329	35	4	was	be	AUX
ecletica-329	35	5	obtained	obtain	VERB
ecletica-329	35	6	from	from	ADP
ecletica-329	35	7	protein	protein	NOUN
ecletica-329	35	8	data	datum	NOUN
ecletica-329	35	9	bank	bank	NOUN
ecletica-329	35	10	(	(	PUNCT
ecletica-329	35	11	structure	structure	NOUN
ecletica-329	35	12	1nqd	1nqd	PROPN
ecletica-329	35	13	)	)	PUNCT
ecletica-329	35	14	,	,	PUNCT
ecletica-329	35	15	determined	determine	VERB
ecletica-329	35	16	by	by	ADP
ecletica-329	35	17	x	x	NOUN
ecletica-329	35	18	-	-	NOUN
ecletica-329	35	19	ray	ray	NOUN
ecletica-329	35	20	diffraction	diffraction	NOUN
ecletica-329	35	21	.	.	PUNCT
ecletica-329	36	1	the	the	DET
ecletica-329	36	2	structures	structure	NOUN
ecletica-329	36	3	of	of	ADP
ecletica-329	36	4	the	the	DET
ecletica-329	36	5	collagen	collagen	NOUN
ecletica-329	36	6	co	co	NOUN
ecletica-329	36	7	-	-	VERB
ecletica-329	36	8	crystallized	crystallize	VERB
ecletica-329	36	9	with	with	ADP
ecletica-329	36	10	any	any	DET
ecletica-329	36	11	inhibitor	inhibitor	NOUN
ecletica-329	36	12	are	be	AUX
ecletica-329	36	13	not	not	PART
ecletica-329	36	14	known	know	VERB
ecletica-329	36	15	.	.	PUNCT
ecletica-329	37	1	therefore	therefore	ADV
ecletica-329	37	2	the	the	DET
ecletica-329	37	3	area	area	NOUN
ecletica-329	37	4	of	of	ADP
ecletica-329	37	5	the	the	DET
ecletica-329	37	6	surface	surface	NOUN
ecletica-329	37	7	of	of	ADP
ecletica-329	37	8	the	the	DET
ecletica-329	37	9	enzyme	enzyme	NOUN
ecletica-329	37	10	capable	capable	ADJ
ecletica-329	37	11	to	to	PART
ecletica-329	37	12	interact	interact	VERB
ecletica-329	37	13	with	with	ADP
ecletica-329	37	14	ligands	ligand	NOUN
ecletica-329	37	15	had	have	VERB
ecletica-329	37	16	to	to	PART
ecletica-329	37	17	be	be	AUX
ecletica-329	37	18	obtained	obtain	VERB
ecletica-329	37	19	by	by	ADP
ecletica-329	37	20	simulation	simulation	NOUN
ecletica-329	37	21	.	.	PUNCT
ecletica-329	38	1	for	for	ADP
ecletica-329	38	2	this	this	DET
ecletica-329	38	3	purpose	purpose	NOUN
ecletica-329	38	4	,	,	PUNCT
ecletica-329	38	5	a	a	DET
ecletica-329	38	6	model	model	NOUN
ecletica-329	38	7	of	of	ADP
ecletica-329	38	8	a	a	DET
ecletica-329	38	9	fragment	fragment	NOUN
ecletica-329	38	10	of	of	ADP
ecletica-329	38	11	collagen	collagen	NOUN
ecletica-329	38	12	,	,	PUNCT
ecletica-329	38	13	constituted	constitute	VERB
ecletica-329	38	14	by	by	ADP
ecletica-329	38	15	the	the	DET
ecletica-329	38	16	hexapeptide	hexapeptide	NOUN
ecletica-329	38	17	pro	pro	ADJ
ecletica-329	38	18	-	-	ADJ
ecletica-329	38	19	pro	pro	ADJ
ecletica-329	38	20	-	-	ADJ
ecletica-329	38	21	gly	gly	ADJ
ecletica-329	38	22	-	-	PUNCT
ecletica-329	38	23	pro	pro	ADJ
ecletica-329	38	24	-	-	ADJ
ecletica-329	38	25	pro	pro	ADJ
ecletica-329	38	26	-	-	ADJ
ecletica-329	38	27	gly	gly	ADJ
ecletica-329	38	28	,	,	PUNCT
ecletica-329	38	29	was	be	AUX
ecletica-329	38	30	positioned	position	VERB
ecletica-329	38	31	close	close	ADV
ecletica-329	38	32	to	to	ADP
ecletica-329	38	33	active	active	ADJ
ecletica-329	38	34	center	center	NOUN
ecletica-329	38	35	amino	amino	NOUN
ecletica-329	38	36	acids	acid	NOUN
ecletica-329	38	37	residues	residue	NOUN
ecletica-329	38	38	and	and	CCONJ
ecletica-329	38	39	then	then	ADV
ecletica-329	38	40	performed	perform	VERB
ecletica-329	38	41	a	a	DET
ecletica-329	38	42	grid	grid	NOUN
ecletica-329	38	43	calculation	calculation	NOUN
ecletica-329	38	44	[	[	X
ecletica-329	38	45	10	10	NUM
ecletica-329	38	46	]	]	PUNCT
ecletica-329	38	47	.	.	PUNCT
ecletica-329	39	1	docking	dock	VERB
ecletica-329	39	2	calculation	calculation	NOUN
ecletica-329	39	3	and	and	CCONJ
ecletica-329	39	4	a	a	DET
ecletica-329	39	5	mixed	mixed	ADJ
ecletica-329	39	6	quantum	quantum	NOUN
ecletica-329	39	7	-	-	ADJ
ecletica-329	39	8	classical	classical	ADJ
ecletica-329	39	9	mechanics	mechanic	NOUN
ecletica-329	39	10	determination	determination	NOUN
ecletica-329	39	11	of	of	ADP
ecletica-329	39	12	ligand	ligand	NOUN
ecletica-329	39	13	-	-	PUNCT
ecletica-329	39	14	enzyme	enzyme	NOUN
ecletica-329	39	15	interaction	interaction	NOUN
ecletica-329	39	16	energy	energy	NOUN
ecletica-329	39	17	,	,	PUNCT
ecletica-329	39	18	led	lead	VERB
ecletica-329	39	19	to	to	ADP
ecletica-329	39	20	the	the	DET
ecletica-329	39	21	most	most	ADV
ecletica-329	39	22	probable	probable	ADJ
ecletica-329	39	23	complex	complex	ADJ
ecletica-329	39	24	structures	structure	NOUN
ecletica-329	39	25	[	[	X
ecletica-329	39	26	10	10	NUM
ecletica-329	39	27	,	,	PUNCT
ecletica-329	39	28	11	11	NUM
ecletica-329	39	29	]	]	PUNCT
ecletica-329	39	30	.	.	PUNCT
ecletica-329	40	1	48	48	NUM
ecletica-329	40	2	ecl	ecl	PROPN
ecletica-329	40	3	.	.	PROPN
ecletica-329	40	4	quím	quím	PROPN
ecletica-329	40	5	.	.	PUNCT
ecletica-329	40	6	,	,	PUNCT
ecletica-329	40	7	são	são	PROPN
ecletica-329	40	8	paulo	paulo	PROPN
ecletica-329	40	9	,	,	PUNCT
ecletica-329	40	10	33(4	33(4	NUM
ecletica-329	40	11	):	):	PUNCT
ecletica-329	40	12	47	47	NUM
ecletica-329	40	13	-	-	SYM
ecletica-329	40	14	52	52	NUM
ecletica-329	40	15	,	,	PUNCT
ecletica-329	40	16	2008	2008	NUM
ecletica-329	40	17	calculations	calculation	NOUN
ecletica-329	40	18	were	be	AUX
ecletica-329	40	19	performed	perform	VERB
ecletica-329	40	20	on	on	ADP
ecletica-329	40	21	a	a	DET
ecletica-329	40	22	compaq	compaq	NOUN
ecletica-329	40	23	ap400	ap400	INTJ
ecletica-329	40	24	workstation	workstation	NOUN
ecletica-329	40	25	with	with	ADP
ecletica-329	40	26	two	two	NUM
ecletica-329	40	27	processors	processor	NOUN
ecletica-329	40	28	(	(	PUNCT
ecletica-329	40	29	windows	window	NOUN
ecletica-329	40	30	software	software	NOUN
ecletica-329	40	31	for	for	ADP
ecletica-329	40	32	classical	classical	ADJ
ecletica-329	40	33	and	and	CCONJ
ecletica-329	40	34	quantum	quantum	ADJ
ecletica-329	40	35	mechanics	mechanic	NOUN
ecletica-329	40	36	energy	energy	NOUN
ecletica-329	40	37	minimization	minimization	NOUN
ecletica-329	40	38	)	)	PUNCT
ecletica-329	40	39	and	and	CCONJ
ecletica-329	40	40	on	on	ADP
ecletica-329	40	41	a	a	DET
ecletica-329	40	42	silicon	silicon	NOUN
ecletica-329	40	43	graphics	graphic	NOUN
ecletica-329	40	44	octane	octane	NOUN
ecletica-329	40	45	workstation	workstation	NOUN
ecletica-329	40	46	(	(	PUNCT
ecletica-329	40	47	unix	unix	NOUN
ecletica-329	40	48	software	software	NOUN
ecletica-329	40	49	for	for	ADP
ecletica-329	40	50	docking	docking	NOUN
ecletica-329	40	51	and	and	CCONJ
ecletica-329	40	52	ab	ab	PROPN
ecletica-329	40	53	initio	initio	NOUN
ecletica-329	40	54	quantum	quantum	NOUN
ecletica-329	40	55	mechanics	mechanic	NOUN
ecletica-329	40	56	calculation	calculation	NOUN
ecletica-329	40	57	)	)	PUNCT
ecletica-329	40	58	.	.	PUNCT
ecletica-329	41	1	for	for	ADP
ecletica-329	41	2	the	the	DET
ecletica-329	41	3	former	former	ADJ
ecletica-329	41	4	it	it	PRON
ecletica-329	41	5	was	be	AUX
ecletica-329	41	6	used	use	VERB
ecletica-329	41	7	cache	cache	NOUN
ecletica-329	41	8	worksystem	worksystem	NOUN
ecletica-329	41	9	5.04	5.04	NUM
ecletica-329	41	10	for	for	ADP
ecletica-329	41	11	windows	window	NOUN
ecletica-329	41	12	(	(	PUNCT
ecletica-329	41	13	fujitsu	fujitsu	PROPN
ecletica-329	41	14	systems	systems	PROPN
ecletica-329	41	15	business	business	NOUN
ecletica-329	41	16	of	of	ADP
ecletica-329	41	17	america	america	PROPN
ecletica-329	41	18	,	,	PUNCT
ecletica-329	41	19	inc	inc	PROPN
ecletica-329	41	20	.	.	PROPN
ecletica-329	41	21	,	,	PUNCT
ecletica-329	41	22	beaverton	beaverton	PROPN
ecletica-329	41	23	,	,	PUNCT
ecletica-329	41	24	or	or	CCONJ
ecletica-329	41	25	,	,	PUNCT
ecletica-329	41	26	usa	usa	PROPN
ecletica-329	41	27	)	)	PUNCT
ecletica-329	42	1	[	[	X
ecletica-329	42	2	12	12	NUM
ecletica-329	42	3	]	]	PUNCT
ecletica-329	42	4	and	and	CCONJ
ecletica-329	42	5	for	for	ADP
ecletica-329	42	6	the	the	DET
ecletica-329	42	7	last	last	ADJ
ecletica-329	42	8	first	first	ADJ
ecletica-329	42	9	discovery	discovery	NOUN
ecletica-329	42	10	1.8	1.8	NUM
ecletica-329	42	11	(	(	PUNCT
ecletica-329	42	12	modules	module	NOUN
ecletica-329	42	13	:	:	PUNCT
ecletica-329	42	14	glide	glide	NOUN
ecletica-329	42	15	;	;	PUNCT
ecletica-329	42	16	liaison	liaison	NOUN
ecletica-329	42	17	;	;	PUNCT
ecletica-329	42	18	qsite	qsite	NOUN
ecletica-329	42	19	;	;	PUNCT
ecletica-329	42	20	impact	impact	NOUN
ecletica-329	42	21	)	)	PUNCT
ecletica-329	42	22	and	and	CCONJ
ecletica-329	42	23	jaguar	jaguar	PROPN
ecletica-329	42	24	4.1	4.1	NUM
ecletica-329	42	25	.	.	PUNCT
ecletica-329	43	1	for	for	ADP
ecletica-329	43	2	irix	irix	NOUN
ecletica-329	43	3	(	(	PUNCT
ecletica-329	43	4	in	in	ADP
ecletica-329	43	5	other	other	ADJ
ecletica-329	43	6	words	word	NOUN
ecletica-329	43	7	,	,	PUNCT
ecletica-329	43	8	sgi	sgi	NOUN
ecletica-329	43	9	unix	unix	NOUN
ecletica-329	43	10	)	)	PUNCT
ecletica-329	43	11	(	(	PUNCT
ecletica-329	43	12	schrödinger	schrödinger	PROPN
ecletica-329	43	13	inc	inc	PROPN
ecletica-329	43	14	.	.	PROPN
ecletica-329	43	15	,	,	PUNCT
ecletica-329	43	16	portland	portland	PROPN
ecletica-329	43	17	,	,	PUNCT
ecletica-329	43	18	or	or	CCONJ
ecletica-329	43	19	,	,	PUNCT
ecletica-329	43	20	usa).[10	usa).[10	PROPN
ecletica-329	43	21	,	,	PUNCT
ecletica-329	43	22	11	11	NUM
ecletica-329	43	23	]	]	PUNCT
ecletica-329	43	24	results	result	NOUN
ecletica-329	43	25	and	and	CCONJ
ecletica-329	43	26	discussion	discussion	VERB
ecletica-329	43	27	the	the	DET
ecletica-329	43	28	kinetic	kinetic	ADJ
ecletica-329	43	29	parameters	parameter	NOUN
ecletica-329	43	30	for	for	ADP
ecletica-329	43	31	the	the	DET
ecletica-329	43	32	collagenase	collagenase	NOUN
ecletica-329	43	33	-	-	PUNCT
ecletica-329	43	34	catalyzed	catalyze	VERB
ecletica-329	43	35	hydrolysis	hydrolysis	NOUN
ecletica-329	43	36	of	of	ADP
ecletica-329	43	37	bovine	bovine	ADJ
ecletica-329	43	38	collagen	collagen	NOUN
ecletica-329	43	39	were	be	AUX
ecletica-329	43	40	determined	determine	VERB
ecletica-329	43	41	from	from	ADP
ecletica-329	43	42	the	the	DET
ecletica-329	43	43	plot	plot	NOUN
ecletica-329	43	44	of	of	ADP
ecletica-329	43	45	absorbance	absorbance	NOUN
ecletica-329	43	46	of	of	ADP
ecletica-329	43	47	ninhydrine	ninhydrine	NOUN
ecletica-329	43	48	-	-	PUNCT
ecletica-329	43	49	amino	amino	NOUN
ecletica-329	43	50	acid	acid	NOUN
ecletica-329	43	51	reaction	reaction	NOUN
ecletica-329	43	52	product	product	NOUN
ecletica-329	43	53	versus	versus	ADP
ecletica-329	43	54	collagen	collagen	NOUN
ecletica-329	43	55	concentration	concentration	NOUN
ecletica-329	43	56	in	in	ADP
ecletica-329	43	57	mol	mol	PROPN
ecletica-329	43	58	/	/	SYM
ecletica-329	43	59	l	l	NOUN
ecletica-329	43	60	,	,	PUNCT
ecletica-329	43	61	considering	consider	VERB
ecletica-329	43	62	the	the	DET
ecletica-329	43	63	protein	protein	NOUN
ecletica-329	43	64	molecular	molecular	ADJ
ecletica-329	43	65	weight	weight	NOUN
ecletica-329	43	66	as	as	SCONJ
ecletica-329	43	67	3,00	3,00	PROPN
ecletica-329	43	68	x	x	SYM
ecletica-329	43	69	105	105	NUM
ecletica-329	43	70	d.	d.	NOUN
ecletica-329	43	71	this	this	DET
ecletica-329	43	72	system	system	NOUN
ecletica-329	43	73	displays	display	VERB
ecletica-329	43	74	a	a	DET
ecletica-329	43	75	standard	standard	ADJ
ecletica-329	43	76	michaelis	michaeli	NOUN
ecletica-329	43	77	-	-	PUNCT
ecletica-329	43	78	menten	menten	VERB
ecletica-329	43	79	kinetics	kinetic	NOUN
ecletica-329	43	80	with	with	ADP
ecletica-329	43	81	a	a	DET
ecletica-329	43	82	v	v	NOUN
ecletica-329	43	83	=	=	SYM
ecletica-329	43	84	1,45	1,45	NUM
ecletica-329	43	85	µkat	µkat	NOUN
ecletica-329	43	86	and	and	CCONJ
ecletica-329	43	87	km	km	PROPN
ecletica-329	43	88	=	=	SYM
ecletica-329	43	89	19,9	19,9	NUM
ecletica-329	43	90	µm	µm	NOUN
ecletica-329	43	91	.	.	PUNCT
ecletica-329	44	1	the	the	DET
ecletica-329	44	2	specific	specific	ADJ
ecletica-329	44	3	activity	activity	NOUN
ecletica-329	44	4	results	result	NOUN
ecletica-329	44	5	equal	equal	ADJ
ecletica-329	44	6	to	to	ADP
ecletica-329	44	7	363	363	NUM
ecletica-329	44	8	kat	kat	PROPN
ecletica-329	44	9	/	/	SYM
ecletica-329	44	10	kg	kg	PROPN
ecletica-329	44	11	.	.	PUNCT
ecletica-329	45	1	only	only	ADV
ecletica-329	45	2	piroxicam	piroxicam	PROPN
ecletica-329	45	3	inhibited	inhibit	VERB
ecletica-329	45	4	the	the	DET
ecletica-329	45	5	bacterial	bacterial	ADJ
ecletica-329	45	6	collagenase	collagenase	NOUN
ecletica-329	45	7	among	among	ADP
ecletica-329	45	8	all	all	DET
ecletica-329	45	9	the	the	DET
ecletica-329	45	10	tested	test	VERB
ecletica-329	45	11	drugs	drug	NOUN
ecletica-329	45	12	(	(	PUNCT
ecletica-329	45	13	fig	fig	NOUN
ecletica-329	45	14	.	.	PUNCT
ecletica-329	46	1	4	4	NUM
ecletica-329	46	2	)	)	PUNCT
ecletica-329	46	3	.	.	PUNCT
ecletica-329	47	1	the	the	DET
ecletica-329	47	2	others	other	NOUN
ecletica-329	47	3	had	have	VERB
ecletica-329	47	4	no	no	DET
ecletica-329	47	5	significant	significant	ADJ
ecletica-329	47	6	effect	effect	NOUN
ecletica-329	47	7	(	(	PUNCT
ecletica-329	47	8	including	include	VERB
ecletica-329	47	9	the	the	DET
ecletica-329	47	10	remaining	remain	VERB
ecletica-329	47	11	oxicans	oxican	NOUN
ecletica-329	47	12	,	,	PUNCT
ecletica-329	47	13	fig	fig	NOUN
ecletica-329	47	14	.	.	PUNCT
ecletica-329	48	1	1	1	NUM
ecletica-329	48	2	,	,	PUNCT
ecletica-329	48	3	doxycycline	doxycycline	NOUN
ecletica-329	48	4	,	,	PUNCT
ecletica-329	48	5	fig	fig	NOUN
ecletica-329	48	6	.	.	PUNCT
ecletica-329	49	1	2	2	NUM
ecletica-329	49	2	,	,	PUNCT
ecletica-329	49	3	and	and	CCONJ
ecletica-329	49	4	tetracycline	tetracycline	NOUN
ecletica-329	49	5	,	,	PUNCT
ecletica-329	49	6	fig	fig	NOUN
ecletica-329	49	7	.	.	PUNCT
ecletica-329	50	1	3	3	NUM
ecletica-329	50	2	)	)	PUNCT
ecletica-329	50	3	,	,	PUNCT
ecletica-329	50	4	except	except	SCONJ
ecletica-329	50	5	alendronate	alendronate	NOUN
ecletica-329	50	6	that	that	PRON
ecletica-329	50	7	increased	increase	VERB
ecletica-329	50	8	enzyme	enzyme	NOUN
ecletica-329	50	9	activity	activity	NOUN
ecletica-329	50	10	(	(	PUNCT
ecletica-329	50	11	fig	fig	NOUN
ecletica-329	50	12	.	.	PUNCT
ecletica-329	50	13	5	5	NUM
ecletica-329	50	14	)	)	PUNCT
ecletica-329	50	15	.	.	PUNCT
ecletica-329	51	1	figure	figure	NOUN
ecletica-329	51	2	1	1	NUM
ecletica-329	51	3	.	.	PUNCT
ecletica-329	52	1	effect	effect	NOUN
ecletica-329	52	2	of	of	ADP
ecletica-329	52	3	oxicans	oxican	NOUN
ecletica-329	52	4	upon	upon	SCONJ
ecletica-329	52	5	activity	activity	NOUN
ecletica-329	52	6	of	of	ADP
ecletica-329	52	7	c.	c.	PROPN
ecletica-329	52	8	histolyticum	histolyticum	PROPN
ecletica-329	52	9	collagenase	collagenase	PROPN
ecletica-329	52	10	,	,	PUNCT
ecletica-329	52	11	measured	measure	VERB
ecletica-329	52	12	by	by	ADP
ecletica-329	52	13	absorbance	absorbance	NOUN
ecletica-329	52	14	at	at	ADP
ecletica-329	52	15	600	600	NUM
ecletica-329	52	16	nm	nm	NOUN
ecletica-329	52	17	of	of	ADP
ecletica-329	52	18	the	the	DET
ecletica-329	52	19	ninhydrine	ninhydrine	NOUN
ecletica-329	52	20	-	-	PUNCT
ecletica-329	52	21	amino	amino	NOUN
ecletica-329	52	22	acid	acid	NOUN
ecletica-329	52	23	reaction	reaction	NOUN
ecletica-329	52	24	product	product	NOUN
ecletica-329	52	25	.	.	PUNCT
ecletica-329	53	1	eq06	eq06	PROPN
ecletica-329	53	2	-	-	PUNCT
ecletica-329	53	3	af	af	PROPN
ecletica-329	53	4	4/12/08	4/12/08	NUM
ecletica-329	53	5	9:55	9:55	NUM
ecletica-329	53	6	page	page	NOUN
ecletica-329	53	7	48	48	NUM
ecletica-329	53	8	49ecl	49ecl	NOUN
ecletica-329	53	9	.	.	PUNCT
ecletica-329	54	1	quím	quím	PROPN
ecletica-329	54	2	.	.	PUNCT
ecletica-329	55	1	,	,	PUNCT
ecletica-329	55	2	são	são	PROPN
ecletica-329	55	3	paulo	paulo	PROPN
ecletica-329	55	4	,	,	PUNCT
ecletica-329	55	5	33(4	33(4	NUM
ecletica-329	55	6	):	):	PUNCT
ecletica-329	55	7	47	47	NUM
ecletica-329	55	8	-	-	SYM
ecletica-329	55	9	52	52	NUM
ecletica-329	55	10	,	,	PUNCT
ecletica-329	55	11	2008	2008	NUM
ecletica-329	55	12	figure	figure	NOUN
ecletica-329	55	13	3	3	NUM
ecletica-329	55	14	.	.	PUNCT
ecletica-329	55	15	effect	effect	NOUN
ecletica-329	55	16	of	of	ADP
ecletica-329	55	17	tetracycline	tetracycline	NOUN
ecletica-329	55	18	upon	upon	SCONJ
ecletica-329	55	19	activity	activity	NOUN
ecletica-329	55	20	of	of	ADP
ecletica-329	55	21	c.	c.	PROPN
ecletica-329	55	22	histolyticum	histolyticum	PROPN
ecletica-329	55	23	collagenase	collagenase	PROPN
ecletica-329	55	24	.	.	PUNCT
ecletica-329	56	1	the	the	DET
ecletica-329	56	2	constant	constant	ADJ
ecletica-329	56	3	of	of	ADP
ecletica-329	56	4	inhibition	inhibition	NOUN
ecletica-329	56	5	ki	ki	PROPN
ecletica-329	56	6	of	of	ADP
ecletica-329	56	7	the	the	DET
ecletica-329	56	8	system	system	NOUN
ecletica-329	56	9	piroxicam	piroxicam	NOUN
ecletica-329	56	10	-	-	PUNCT
ecletica-329	56	11	collagenase	collagenase	NOUN
ecletica-329	56	12	(	(	PUNCT
ecletica-329	56	13	constant	constant	ADJ
ecletica-329	56	14	of	of	ADP
ecletica-329	56	15	enzymeinhibitor	enzymeinhibitor	NOUN
ecletica-329	56	16	dissociation	dissociation	NOUN
ecletica-329	56	17	)	)	PUNCT
ecletica-329	56	18	was	be	AUX
ecletica-329	56	19	calculated	calculate	VERB
ecletica-329	56	20	starting	start	VERB
ecletica-329	56	21	from	from	ADP
ecletica-329	56	22	the	the	DET
ecletica-329	56	23	michaelis	michaelis	ADJ
ecletica-329	56	24	-	-	PUNCT
ecletica-329	56	25	menten	menten	ADJ
ecletica-329	56	26	graph	graph	NOUN
ecletica-329	56	27	,	,	PUNCT
ecletica-329	56	28	namely	namely	ADV
ecletica-329	56	29	:	:	PUNCT
ecletica-329	56	30	kma	kma	X
ecletica-329	56	31	=	=	PUNCT
ecletica-329	57	1	6,81	6,81	NUM
ecletica-329	57	2	mg	mg	NUM
ecletica-329	57	3	/	/	SYM
ecletica-329	57	4	ml	ml	NOUN
ecletica-329	57	5	=	=	NOUN
ecletica-329	58	1	22,7	22,7	NUM
ecletica-329	58	2	µm	µm	ADP
ecletica-329	58	3	v	v	NOUN
ecletica-329	58	4	=	=	SYM
ecletica-329	58	5	1,07	1,07	NUM
ecletica-329	58	6	∆a/5h	∆a/5h	NOUN
ecletica-329	58	7	or	or	CCONJ
ecletica-329	58	8	1,37	1,37	NUM
ecletica-329	58	9	µkat	µkat	NOUN
ecletica-329	58	10	where	where	SCONJ
ecletica-329	58	11	kma	kma	PROPN
ecletica-329	58	12	is	be	AUX
ecletica-329	58	13	the	the	DET
ecletica-329	58	14	apparent	apparent	ADJ
ecletica-329	58	15	michaelis	michaeli	NOUN
ecletica-329	58	16	constant	constant	ADJ
ecletica-329	58	17	.	.	PUNCT
ecletica-329	59	1	then	then	ADV
ecletica-329	59	2	:	:	PUNCT
ecletica-329	59	3	ki	ki	PROPN
ecletica-329	59	4	=	=	PUNCT
ecletica-329	59	5	km	km	PROPN
ecletica-329	59	6	[	[	PUNCT
ecletica-329	59	7	i	i	PRON
ecletica-329	59	8	]	]	PUNCT
ecletica-329	59	9	/	/	SYM
ecletica-329	59	10	kma	kma	PROPN
ecletica-329	59	11	km	km	PROPN
ecletica-329	59	12	,	,	PUNCT
ecletica-329	59	13	where	where	SCONJ
ecletica-329	59	14	[	[	PUNCT
ecletica-329	59	15	i	i	X
ecletica-329	59	16	]	]	PUNCT
ecletica-329	59	17	is	be	AUX
ecletica-329	59	18	the	the	DET
ecletica-329	59	19	inhibitor	inhibitor	NOUN
ecletica-329	59	20	concentration	concentration	NOUN
ecletica-329	59	21	,	,	PUNCT
ecletica-329	60	1	[	[	X
ecletica-329	60	2	piroxicam	piroxicam	X
ecletica-329	60	3	]	]	X
ecletica-329	60	4	.	.	PUNCT
ecletica-329	61	1	therefore	therefore	ADV
ecletica-329	61	2	,	,	PUNCT
ecletica-329	61	3	ki	ki	PROPN
ecletica-329	61	4	=	=	PUNCT
ecletica-329	62	1	1,42	1,42	NUM
ecletica-329	62	2	mm	mm	INTJ
ecletica-329	62	3	the	the	DET
ecletica-329	62	4	maximum	maximum	ADJ
ecletica-329	62	5	reaction	reaction	NOUN
ecletica-329	62	6	speed	speed	NOUN
ecletica-329	62	7	measured	measure	VERB
ecletica-329	62	8	in	in	ADP
ecletica-329	62	9	presence	presence	NOUN
ecletica-329	62	10	of	of	ADP
ecletica-329	62	11	piroxicam	piroxicam	PROPN
ecletica-329	62	12	was	be	AUX
ecletica-329	62	13	the	the	DET
ecletica-329	62	14	same	same	ADJ
ecletica-329	62	15	of	of	ADP
ecletica-329	62	16	the	the	DET
ecletica-329	62	17	reaction	reaction	NOUN
ecletica-329	62	18	without	without	ADP
ecletica-329	62	19	inhibitor	inhibitor	NOUN
ecletica-329	62	20	,	,	PUNCT
ecletica-329	62	21	within	within	ADP
ecletica-329	62	22	the	the	DET
ecletica-329	62	23	experimental	experimental	ADJ
ecletica-329	62	24	uncertainty	uncertainty	NOUN
ecletica-329	62	25	,	,	PUNCT
ecletica-329	62	26	what	what	PRON
ecletica-329	62	27	confirms	confirm	VERB
ecletica-329	62	28	the	the	DET
ecletica-329	62	29	competitive	competitive	ADJ
ecletica-329	62	30	nature	nature	NOUN
ecletica-329	62	31	of	of	ADP
ecletica-329	62	32	the	the	DET
ecletica-329	62	33	process	process	NOUN
ecletica-329	62	34	.	.	PUNCT
ecletica-329	63	1	the	the	DET
ecletica-329	63	2	apparent	apparent	ADJ
ecletica-329	63	3	michaelis	michaelis	ADJ
ecletica-329	63	4	constant	constant	ADJ
ecletica-329	63	5	has	have	VERB
ecletica-329	63	6	a	a	DET
ecletica-329	63	7	value	value	NOUN
ecletica-329	63	8	only	only	ADV
ecletica-329	63	9	14	14	NUM
ecletica-329	63	10	%	%	NOUN
ecletica-329	63	11	greater	great	ADJ
ecletica-329	63	12	of	of	ADP
ecletica-329	63	13	the	the	DET
ecletica-329	63	14	true	true	ADJ
ecletica-329	63	15	one	one	NOUN
ecletica-329	63	16	,	,	PUNCT
ecletica-329	63	17	what	what	PRON
ecletica-329	63	18	implies	imply	VERB
ecletica-329	63	19	in	in	ADP
ecletica-329	63	20	a	a	DET
ecletica-329	63	21	relatively	relatively	ADV
ecletica-329	63	22	high	high	ADJ
ecletica-329	63	23	ki	ki	PROPN
ecletica-329	63	24	(	(	PUNCT
ecletica-329	63	25	1,42	1,42	NUM
ecletica-329	63	26	mm	mm	NOUN
ecletica-329	63	27	)	)	PUNCT
ecletica-329	63	28	,	,	PUNCT
ecletica-329	63	29	indicating	indicate	VERB
ecletica-329	63	30	a	a	DET
ecletica-329	63	31	weak	weak	ADJ
ecletica-329	63	32	inhibitor	inhibitor	NOUN
ecletica-329	63	33	–	–	PUNCT
ecletica-329	63	34	enzyme	enzyme	NOUN
ecletica-329	63	35	affinity	affinity	NOUN
ecletica-329	63	36	.	.	PUNCT
ecletica-329	64	1	in	in	ADP
ecletica-329	64	2	other	other	ADJ
ecletica-329	64	3	words	word	NOUN
ecletica-329	64	4	,	,	PUNCT
ecletica-329	64	5	piroxicam	piroxicam	PROPN
ecletica-329	64	6	is	be	AUX
ecletica-329	64	7	a	a	DET
ecletica-329	64	8	poor	poor	ADJ
ecletica-329	64	9	candidate	candidate	NOUN
ecletica-329	64	10	for	for	ADP
ecletica-329	64	11	a	a	DET
ecletica-329	64	12	drug	drug	NOUN
ecletica-329	64	13	as	as	ADP
ecletica-329	64	14	a	a	DET
ecletica-329	64	15	bacterial	bacterial	ADJ
ecletica-329	64	16	collagenase	collagenase	NOUN
ecletica-329	64	17	inhibitor	inhibitor	NOUN
ecletica-329	64	18	.	.	PUNCT
ecletica-329	65	1	however	however	ADV
ecletica-329	65	2	,	,	PUNCT
ecletica-329	65	3	maybe	maybe	ADV
ecletica-329	65	4	a	a	DET
ecletica-329	65	5	good	good	ADJ
ecletica-329	65	6	starting	starting	NOUN
ecletica-329	65	7	point	point	NOUN
ecletica-329	65	8	to	to	PART
ecletica-329	65	9	search	search	VERB
ecletica-329	65	10	more	more	ADV
ecletica-329	65	11	active	active	ADJ
ecletica-329	65	12	derivates	derivate	NOUN
ecletica-329	65	13	.	.	PUNCT
ecletica-329	66	1	as	as	SCONJ
ecletica-329	66	2	stated	state	VERB
ecletica-329	66	3	above	above	ADV
ecletica-329	66	4	,	,	PUNCT
ecletica-329	66	5	the	the	DET
ecletica-329	66	6	others	other	NOUN
ecletica-329	66	7	ligands	ligand	NOUN
ecletica-329	66	8	did	do	AUX
ecletica-329	66	9	not	not	PART
ecletica-329	66	10	inhibit	inhibit	VERB
ecletica-329	66	11	the	the	DET
ecletica-329	66	12	collagenase	collagenase	NOUN
ecletica-329	66	13	of	of	ADP
ecletica-329	66	14	c.	c.	PROPN
ecletica-329	66	15	histolyticum	histolyticum	PROPN
ecletica-329	66	16	.	.	PUNCT
ecletica-329	67	1	curiously	curiously	ADV
ecletica-329	67	2	,	,	PUNCT
ecletica-329	67	3	the	the	DET
ecletica-329	67	4	alendronate	alendronate	NOUN
ecletica-329	67	5	increased	increase	VERB
ecletica-329	67	6	enzyme	enzyme	NOUN
ecletica-329	67	7	activity	activity	NOUN
ecletica-329	67	8	(	(	PUNCT
ecletica-329	67	9	fig	fig	NOUN
ecletica-329	67	10	.	.	PUNCT
ecletica-329	67	11	5	5	NUM
ecletica-329	67	12	)	)	PUNCT
ecletica-329	67	13	.	.	PUNCT
ecletica-329	68	1	figure	figure	NOUN
ecletica-329	68	2	2	2	NUM
ecletica-329	68	3	.	.	PUNCT
ecletica-329	68	4	effect	effect	NOUN
ecletica-329	68	5	of	of	ADP
ecletica-329	68	6	doxycycline	doxycycline	NOUN
ecletica-329	68	7	upon	upon	SCONJ
ecletica-329	68	8	activity	activity	NOUN
ecletica-329	68	9	of	of	ADP
ecletica-329	68	10	c.	c.	PROPN
ecletica-329	68	11	histolyticum	histolyticum	PROPN
ecletica-329	68	12	collagenase	collagenase	PROPN
ecletica-329	68	13	.	.	PUNCT
ecletica-329	69	1	figure	figure	NOUN
ecletica-329	69	2	4	4	NUM
ecletica-329	69	3	.	.	PUNCT
ecletica-329	69	4	effect	effect	NOUN
ecletica-329	69	5	of	of	ADP
ecletica-329	69	6	piroxicam	piroxicam	NOUN
ecletica-329	69	7	upon	upon	SCONJ
ecletica-329	69	8	activity	activity	NOUN
ecletica-329	69	9	of	of	ADP
ecletica-329	69	10	c.	c.	PROPN
ecletica-329	69	11	histolyticum	histolyticum	PROPN
ecletica-329	69	12	collagenase	collagenase	PROPN
ecletica-329	69	13	,	,	PUNCT
ecletica-329	69	14	measured	measure	VERB
ecletica-329	69	15	by	by	ADP
ecletica-329	69	16	absorbance	absorbance	NOUN
ecletica-329	69	17	at	at	ADP
ecletica-329	69	18	600	600	NUM
ecletica-329	69	19	nm	nm	NOUN
ecletica-329	69	20	of	of	ADP
ecletica-329	69	21	the	the	DET
ecletica-329	69	22	ninhydrine	ninhydrine	NOUN
ecletica-329	69	23	-	-	PUNCT
ecletica-329	69	24	amino	amino	NOUN
ecletica-329	69	25	acid	acid	NOUN
ecletica-329	69	26	reaction	reaction	NOUN
ecletica-329	69	27	product	product	NOUN
ecletica-329	69	28	.	.	PUNCT
ecletica-329	70	1	ic50	ic50	PROPN
ecletica-329	70	2	=	=	PUNCT
ecletica-329	71	1	2,2	2,2	NUM
ecletica-329	71	2	x	x	SYM
ecletica-329	71	3	10	10	NUM
ecletica-329	71	4	-	-	SYM
ecletica-329	71	5	4	4	NUM
ecletica-329	71	6	mol	mol	NOUN
ecletica-329	71	7	/	/	SYM
ecletica-329	71	8	l.	l.	PROPN
ecletica-329	71	9	figure	figure	NOUN
ecletica-329	71	10	5	5	NUM
ecletica-329	71	11	.	.	PUNCT
ecletica-329	71	12	effect	effect	NOUN
ecletica-329	71	13	of	of	ADP
ecletica-329	71	14	alendronate	alendronate	NOUN
ecletica-329	71	15	upon	upon	SCONJ
ecletica-329	71	16	activity	activity	NOUN
ecletica-329	71	17	of	of	ADP
ecletica-329	71	18	c.	c.	PROPN
ecletica-329	71	19	histolyticum	histolyticum	PROPN
ecletica-329	71	20	collagenase	collagenase	PROPN
ecletica-329	71	21	,	,	PUNCT
ecletica-329	71	22	measured	measure	VERB
ecletica-329	71	23	by	by	ADP
ecletica-329	71	24	absorbance	absorbance	NOUN
ecletica-329	71	25	at	at	ADP
ecletica-329	71	26	600	600	NUM
ecletica-329	71	27	nm	nm	NOUN
ecletica-329	71	28	of	of	ADP
ecletica-329	71	29	the	the	DET
ecletica-329	71	30	amino	amino	NOUN
ecletica-329	71	31	-	-	PUNCT
ecletica-329	71	32	amino	amino	NOUN
ecletica-329	71	33	acid	acid	NOUN
ecletica-329	71	34	product	product	NOUN
ecletica-329	71	35	reaction	reaction	NOUN
ecletica-329	71	36	.	.	PUNCT
ecletica-329	72	1	eq06	eq06	PROPN
ecletica-329	72	2	-	-	PUNCT
ecletica-329	72	3	af	af	PROPN
ecletica-329	72	4	4/12/08	4/12/08	NUM
ecletica-329	72	5	9:55	9:55	NUM
ecletica-329	72	6	page	page	NOUN
ecletica-329	72	7	49	49	NUM
ecletica-329	72	8	50	50	NUM
ecletica-329	72	9	ecl	ecl	NOUN
ecletica-329	72	10	.	.	PUNCT
ecletica-329	72	11	quím	quím	PROPN
ecletica-329	72	12	.	.	PUNCT
ecletica-329	72	13	,	,	PUNCT
ecletica-329	72	14	são	são	PROPN
ecletica-329	72	15	paulo	paulo	PROPN
ecletica-329	72	16	,	,	PUNCT
ecletica-329	72	17	33(4	33(4	NUM
ecletica-329	72	18	):	):	PUNCT
ecletica-329	72	19	47	47	NUM
ecletica-329	72	20	-	-	SYM
ecletica-329	72	21	52	52	NUM
ecletica-329	72	22	,	,	PUNCT
ecletica-329	72	23	2008	2008	NUM
ecletica-329	72	24	the	the	DET
ecletica-329	72	25	best	good	ADJ
ecletica-329	72	26	geometries	geometry	NOUN
ecletica-329	72	27	obtained	obtain	VERB
ecletica-329	72	28	through	through	ADP
ecletica-329	72	29	the	the	DET
ecletica-329	72	30	docking	docking	NOUN
ecletica-329	72	31	calculation	calculation	NOUN
ecletica-329	72	32	represent	represent	VERB
ecletica-329	72	33	the	the	DET
ecletica-329	72	34	low	low	ADJ
ecletica-329	72	35	interaction	interaction	NOUN
ecletica-329	72	36	energy	energy	NOUN
ecletica-329	72	37	between	between	ADP
ecletica-329	72	38	ligand	ligand	NOUN
ecletica-329	72	39	-	-	PUNCT
ecletica-329	72	40	enzyme	enzyme	NOUN
ecletica-329	72	41	,	,	PUNCT
ecletica-329	72	42	resulting	result	VERB
ecletica-329	72	43	in	in	ADP
ecletica-329	72	44	stronger	strong	ADJ
ecletica-329	72	45	chemical	chemical	NOUN
ecletica-329	72	46	bonds	bond	NOUN
ecletica-329	72	47	.	.	PUNCT
ecletica-329	73	1	among	among	ADP
ecletica-329	73	2	them	they	PRON
ecletica-329	73	3	stand	stand	VERB
ecletica-329	73	4	out	out	ADP
ecletica-329	73	5	hydrogen	hydrogen	NOUN
ecletica-329	73	6	bonds	bond	NOUN
ecletica-329	73	7	,	,	PUNCT
ecletica-329	73	8	whose	whose	DET
ecletica-329	73	9	involvement	involvement	NOUN
ecletica-329	73	10	of	of	ADP
ecletica-329	73	11	groups	group	NOUN
ecletica-329	73	12	of	of	ADP
ecletica-329	73	13	enzyme	enzyme	NOUN
ecletica-329	73	14	active	active	ADJ
ecletica-329	73	15	site	site	NOUN
ecletica-329	73	16	can	can	AUX
ecletica-329	73	17	explain	explain	VERB
ecletica-329	73	18	the	the	DET
ecletica-329	73	19	effect	effect	NOUN
ecletica-329	73	20	on	on	ADP
ecletica-329	73	21	the	the	DET
ecletica-329	73	22	enzymatic	enzymatic	ADJ
ecletica-329	73	23	activity	activity	NOUN
ecletica-329	73	24	.	.	PUNCT
ecletica-329	74	1	the	the	DET
ecletica-329	74	2	number	number	NOUN
ecletica-329	74	3	and	and	CCONJ
ecletica-329	74	4	the	the	DET
ecletica-329	74	5	position	position	NOUN
ecletica-329	74	6	of	of	ADP
ecletica-329	74	7	hydrogen	hydrogen	NOUN
ecletica-329	74	8	bonds	bond	NOUN
ecletica-329	74	9	formed	form	VERB
ecletica-329	74	10	between	between	ADP
ecletica-329	74	11	ligand	ligand	NOUN
ecletica-329	74	12	and	and	CCONJ
ecletica-329	74	13	enzyme	enzyme	NOUN
ecletica-329	74	14	are	be	AUX
ecletica-329	74	15	described	describe	VERB
ecletica-329	74	16	in	in	ADP
ecletica-329	74	17	the	the	DET
ecletica-329	74	18	table	table	NOUN
ecletica-329	74	19	1	1	NUM
ecletica-329	74	20	.	.	PUNCT
ecletica-329	75	1	all	all	DET
ecletica-329	75	2	the	the	DET
ecletica-329	75	3	best	good	ADJ
ecletica-329	75	4	poses	pose	NOUN
ecletica-329	75	5	obtained	obtain	VERB
ecletica-329	75	6	in	in	ADP
ecletica-329	75	7	the	the	DET
ecletica-329	75	8	“	"	PUNCT
ecletica-329	75	9	docking	docking	NOUN
ecletica-329	75	10	”	"	PUNCT
ecletica-329	75	11	procedure	procedure	NOUN
ecletica-329	75	12	were	be	AUX
ecletica-329	75	13	submitted	submit	VERB
ecletica-329	75	14	to	to	ADP
ecletica-329	75	15	energy	energy	NOUN
ecletica-329	75	16	calculation	calculation	NOUN
ecletica-329	75	17	.	.	PUNCT
ecletica-329	76	1	this	this	DET
ecletica-329	76	2	calculation	calculation	NOUN
ecletica-329	76	3	was	be	AUX
ecletica-329	76	4	mixed	mixed	ADJ
ecletica-329	76	5	:	:	PUNCT
ecletica-329	76	6	ab	ab	PROPN
ecletica-329	76	7	initio	initio	NOUN
ecletica-329	76	8	quantum	quantum	NOUN
ecletica-329	76	9	mechanics	mechanic	NOUN
ecletica-329	76	10	,	,	PUNCT
ecletica-329	76	11	which	which	PRON
ecletica-329	76	12	is	be	AUX
ecletica-329	76	13	more	more	ADV
ecletica-329	76	14	accurate	accurate	ADJ
ecletica-329	76	15	,	,	PUNCT
ecletica-329	76	16	for	for	ADP
ecletica-329	76	17	the	the	DET
ecletica-329	76	18	ligand	ligand	NOUN
ecletica-329	76	19	and	and	CCONJ
ecletica-329	76	20	the	the	DET
ecletica-329	76	21	neighboring	neighboring	NOUN
ecletica-329	76	22	area	area	NOUN
ecletica-329	76	23	of	of	ADP
ecletica-329	76	24	the	the	DET
ecletica-329	76	25	enzyme	enzyme	NOUN
ecletica-329	76	26	,	,	PUNCT
ecletica-329	76	27	and	and	CCONJ
ecletica-329	76	28	classic	classic	ADJ
ecletica-329	76	29	molecular	molecular	ADJ
ecletica-329	76	30	mechanics	mechanic	NOUN
ecletica-329	76	31	for	for	ADP
ecletica-329	76	32	the	the	DET
ecletica-329	76	33	rest	rest	NOUN
ecletica-329	76	34	of	of	ADP
ecletica-329	76	35	the	the	DET
ecletica-329	76	36	protein	protein	NOUN
ecletica-329	76	37	,	,	PUNCT
ecletica-329	76	38	because	because	SCONJ
ecletica-329	76	39	is	be	AUX
ecletica-329	76	40	unviable	unviable	ADJ
ecletica-329	76	41	to	to	ADP
ecletica-329	76	42	perdocking	perdocking	NOUN
ecletica-329	76	43	calculations	calculation	NOUN
ecletica-329	76	44	defined	define	VERB
ecletica-329	76	45	the	the	DET
ecletica-329	76	46	best	good	ADJ
ecletica-329	76	47	geometry	geometry	NOUN
ecletica-329	76	48	for	for	ADP
ecletica-329	76	49	ligand	ligand	NOUN
ecletica-329	76	50	-	-	PUNCT
ecletica-329	76	51	enzyme	enzyme	NOUN
ecletica-329	76	52	interaction	interaction	NOUN
ecletica-329	76	53	.	.	PUNCT
ecletica-329	77	1	the	the	DET
ecletica-329	77	2	best	good	ADJ
ecletica-329	77	3	poses	pose	NOUN
ecletica-329	77	4	between	between	ADP
ecletica-329	77	5	each	each	DET
ecletica-329	77	6	ligand	ligand	NOUN
ecletica-329	77	7	and	and	CCONJ
ecletica-329	77	8	collagenase	collagenase	VERB
ecletica-329	77	9	active	active	ADJ
ecletica-329	77	10	site	site	NOUN
ecletica-329	77	11	were	be	AUX
ecletica-329	77	12	select	select	ADJ
ecletica-329	77	13	.	.	PUNCT
ecletica-329	78	1	see	see	VERB
ecletica-329	78	2	figure	figure	NOUN
ecletica-329	78	3	6	6	NUM
ecletica-329	78	4	as	as	ADP
ecletica-329	78	5	an	an	DET
ecletica-329	78	6	example	example	NOUN
ecletica-329	78	7	.	.	PUNCT
ecletica-329	79	1	tetracycline	tetracycline	PROPN
ecletica-329	79	2	was	be	AUX
ecletica-329	79	3	the	the	DET
ecletica-329	79	4	only	only	ADJ
ecletica-329	79	5	ligand	ligand	NOUN
ecletica-329	79	6	for	for	ADP
ecletica-329	79	7	which	which	PRON
ecletica-329	79	8	a	a	DET
ecletica-329	79	9	favorable	favorable	ADJ
ecletica-329	79	10	interaction	interaction	NOUN
ecletica-329	79	11	with	with	ADP
ecletica-329	79	12	the	the	DET
ecletica-329	79	13	enzyme	enzyme	NOUN
ecletica-329	79	14	was	be	AUX
ecletica-329	79	15	not	not	PART
ecletica-329	79	16	gotten	get	VERB
ecletica-329	79	17	.	.	PUNCT
ecletica-329	80	1	the	the	DET
ecletica-329	80	2	calculation	calculation	NOUN
ecletica-329	80	3	did	do	AUX
ecletica-329	80	4	n’t	not	PART
ecletica-329	80	5	supply	supply	VERB
ecletica-329	80	6	any	any	DET
ecletica-329	80	7	adjustment	adjustment	NOUN
ecletica-329	80	8	of	of	ADP
ecletica-329	80	9	the	the	DET
ecletica-329	80	10	tetracycline	tetracycline	NOUN
ecletica-329	80	11	with	with	ADP
ecletica-329	80	12	the	the	DET
ecletica-329	80	13	active	active	ADJ
ecletica-329	80	14	site	site	NOUN
ecletica-329	80	15	that	that	PRON
ecletica-329	80	16	resulted	result	VERB
ecletica-329	80	17	in	in	ADP
ecletica-329	80	18	attractive	attractive	ADJ
ecletica-329	80	19	interactions	interaction	NOUN
ecletica-329	80	20	among	among	ADP
ecletica-329	80	21	their	their	PRON
ecletica-329	80	22	structures	structure	NOUN
ecletica-329	80	23	.	.	PUNCT
ecletica-329	81	1	table	table	NOUN
ecletica-329	81	2	1	1	NUM
ecletica-329	81	3	.	.	PUNCT
ecletica-329	82	1	hydrogen	hydrogen	NOUN
ecletica-329	82	2	bonds	bond	NOUN
ecletica-329	82	3	between	between	ADP
ecletica-329	82	4	ligands	ligand	NOUN
ecletica-329	82	5	and	and	CCONJ
ecletica-329	82	6	active	active	ADJ
ecletica-329	82	7	site	site	NOUN
ecletica-329	82	8	of	of	ADP
ecletica-329	82	9	clostridium	clostridium	NOUN
ecletica-329	82	10	histolyticum	histolyticum	PROPN
ecletica-329	82	11	collagenase	collagenase	NOUN
ecletica-329	82	12	.	.	PUNCT
ecletica-329	83	1	number	number	NOUN
ecletica-329	83	2	of	of	ADP
ecletica-329	83	3	hydrogen	hydrogen	NOUN
ecletica-329	83	4	bonds	bond	NOUN
ecletica-329	83	5	formed	form	VERB
ecletica-329	83	6	with	with	ADP
ecletica-329	83	7	each	each	DET
ecletica-329	83	8	amino	amino	NOUN
ecletica-329	83	9	acid	acid	NOUN
ecletica-329	83	10	residue	residue	NOUN
ecletica-329	83	11	ligands	ligand	NOUN
ecletica-329	83	12	meloxicam	meloxicam	X
ecletica-329	83	13	tenoxicam	tenoxicam	PROPN
ecletica-329	83	14	piroxicam	piroxicam	PROPN
ecletica-329	83	15	alendronate	alendronate	PROPN
ecletica-329	83	16	doxycycline	doxycycline	NOUN
ecletica-329	83	17	arg	arg	NOUN
ecletica-329	83	18	929	929	NUM
ecletica-329	83	19	3	3	NUM
ecletica-329	83	20	1	1	NUM
ecletica-329	83	21	3	3	NUM
ecletica-329	83	22	2	2	NUM
ecletica-329	83	23	2	2	NUM
ecletica-329	83	24	tyr	tyr	NOUN
ecletica-329	83	25	931	931	NUM
ecletica-329	83	26	1	1	NUM
ecletica-329	83	27	1	1	NUM
ecletica-329	83	28	1	1	NUM
ecletica-329	83	29	thr	thr	NOUN
ecletica-329	83	30	957	957	NUM
ecletica-329	83	31	1	1	NUM
ecletica-329	83	32	his	his	PRON
ecletica-329	83	33	959	959	NUM
ecletica-329	83	34	1	1	NUM
ecletica-329	83	35	asp	asp	NOUN
ecletica-329	83	36	966	966	NUM
ecletica-329	83	37	1	1	NUM
ecletica-329	83	38	figure	figure	NOUN
ecletica-329	83	39	6	6	NUM
ecletica-329	83	40	.	.	PUNCT
ecletica-329	84	1	piroxicam	piroxicam	ADJ
ecletica-329	84	2	bonding	bonding	NOUN
ecletica-329	84	3	to	to	ADP
ecletica-329	84	4	c.	c.	PROPN
ecletica-329	84	5	histolyticum	histolyticum	PROPN
ecletica-329	84	6	collagenase	collagenase	PROPN
ecletica-329	84	7	active	active	ADJ
ecletica-329	84	8	site	site	NOUN
ecletica-329	84	9	.	.	PUNCT
ecletica-329	85	1	form	form	VERB
ecletica-329	85	2	an	an	DET
ecletica-329	85	3	ab	ab	PROPN
ecletica-329	85	4	initio	initio	NOUN
ecletica-329	85	5	quantum	quantum	NOUN
ecletica-329	85	6	mechanics	mechanic	NOUN
ecletica-329	85	7	method	method	NOUN
ecletica-329	85	8	with	with	ADP
ecletica-329	85	9	a	a	DET
ecletica-329	85	10	too	too	ADV
ecletica-329	85	11	many	many	ADJ
ecletica-329	85	12	atoms	atom	NOUN
ecletica-329	85	13	system	system	NOUN
ecletica-329	85	14	like	like	ADP
ecletica-329	85	15	a	a	DET
ecletica-329	85	16	protein	protein	NOUN
ecletica-329	85	17	.	.	PUNCT
ecletica-329	86	1	the	the	DET
ecletica-329	86	2	energy	energy	NOUN
ecletica-329	86	3	of	of	ADP
ecletica-329	86	4	the	the	DET
ecletica-329	86	5	isolated	isolated	ADJ
ecletica-329	86	6	ligand	ligand	NOUN
ecletica-329	86	7	was	be	AUX
ecletica-329	86	8	obtained	obtain	VERB
ecletica-329	86	9	by	by	ADP
ecletica-329	86	10	the	the	DET
ecletica-329	86	11	same	same	ADJ
ecletica-329	86	12	quantum	quantum	ADJ
ecletica-329	86	13	mechanics	mechanic	NOUN
ecletica-329	86	14	method	method	NOUN
ecletica-329	86	15	and	and	CCONJ
ecletica-329	86	16	of	of	ADP
ecletica-329	86	17	the	the	DET
ecletica-329	86	18	free	free	ADJ
ecletica-329	86	19	enzyme	enzyme	NOUN
ecletica-329	86	20	by	by	ADP
ecletica-329	86	21	analogous	analogous	ADJ
ecletica-329	86	22	mixed	mixed	ADJ
ecletica-329	86	23	procedure	procedure	NOUN
ecletica-329	86	24	.	.	PUNCT
ecletica-329	87	1	classic	classic	ADJ
ecletica-329	87	2	molecular	molecular	ADJ
ecletica-329	87	3	mechanics	mechanic	NOUN
ecletica-329	87	4	utilized	utilize	VERB
ecletica-329	87	5	opls	opls	PROPN
ecletica-329	87	6	-	-	PUNCT
ecletica-329	87	7	aa	aa	PROPN
ecletica-329	87	8	force	force	NOUN
ecletica-329	87	9	field	field	NOUN
ecletica-329	87	10	,	,	PUNCT
ecletica-329	87	11	and	and	CCONJ
ecletica-329	87	12	the	the	DET
ecletica-329	87	13	ab	ab	PROPN
ecletica-329	87	14	initio	initio	NOUN
ecletica-329	87	15	quantum	quantum	NOUN
ecletica-329	87	16	mechanics	mechanic	NOUN
ecletica-329	87	17	calculation	calculation	NOUN
ecletica-329	87	18	used	use	VERB
ecletica-329	87	19	a	a	DET
ecletica-329	87	20	density	density	NOUN
ecletica-329	87	21	functional	functional	ADJ
ecletica-329	87	22	theory	theory	NOUN
ecletica-329	87	23	type	type	NOUN
ecletica-329	87	24	b3lyp	b3lyp	PROPN
ecletica-329	87	25	with	with	ADP
ecletica-329	87	26	a	a	DET
ecletica-329	87	27	base	base	NOUN
ecletica-329	87	28	lacvp+	lacvp+	NOUN
ecletica-329	87	29	.	.	PUNCT
ecletica-329	88	1	starting	start	VERB
ecletica-329	88	2	from	from	ADP
ecletica-329	88	3	these	these	DET
ecletica-329	88	4	results	result	NOUN
ecletica-329	88	5	the	the	DET
ecletica-329	88	6	total	total	ADJ
ecletica-329	88	7	ligand	ligand	ADJ
ecletica-329	88	8	-	-	PUNCT
ecletica-329	88	9	enzyme	enzyme	NOUN
ecletica-329	88	10	bond	bond	NOUN
ecletica-329	88	11	energies	energy	NOUN
ecletica-329	88	12	were	be	AUX
ecletica-329	88	13	calculated	calculate	VERB
ecletica-329	88	14	,	,	PUNCT
ecletica-329	88	15	namely	namely	ADV
ecletica-329	88	16	:	:	PUNCT
ecletica-329	88	17	eb	eb	PROPN
ecletica-329	88	18	=	=	PROPN
ecletica-329	88	19	el	el	PROPN
ecletica-329	88	20	+	+	PROPN
ecletica-329	88	21	ee	ee	PROPN
ecletica-329	88	22	ecle	ecle	NOUN
ecletica-329	89	1	where	where	SCONJ
ecletica-329	89	2	:	:	PUNCT
ecletica-329	89	3	eb	eb	PROPN
ecletica-329	89	4	bond	bond	NOUN
ecletica-329	89	5	energy	energy	NOUN
ecletica-329	89	6	,	,	PUNCT
ecletica-329	89	7	el	el	PROPN
ecletica-329	89	8	energy	energy	NOUN
ecletica-329	89	9	of	of	ADP
ecletica-329	89	10	ligand	ligand	NOUN
ecletica-329	89	11	,	,	PUNCT
ecletica-329	89	12	ee	ee	ADP
ecletica-329	89	13	energy	energy	NOUN
ecletica-329	89	14	of	of	ADP
ecletica-329	89	15	enzyme	enzyme	NOUN
ecletica-329	89	16	,	,	PUNCT
ecletica-329	89	17	ecle	ecle	NOUN
ecletica-329	89	18	energy	energy	NOUN
ecletica-329	89	19	of	of	ADP
ecletica-329	89	20	complex	complex	ADJ
ecletica-329	89	21	ligandenzyme	ligandenzyme	NOUN
ecletica-329	89	22	.	.	PUNCT
ecletica-329	90	1	see	see	VERB
ecletica-329	90	2	table	table	NOUN
ecletica-329	90	3	2	2	NUM
ecletica-329	90	4	for	for	ADP
ecletica-329	90	5	the	the	DET
ecletica-329	90	6	results	result	NOUN
ecletica-329	90	7	.	.	PUNCT
ecletica-329	91	1	table	table	NOUN
ecletica-329	91	2	2	2	NUM
ecletica-329	91	3	.	.	PUNCT
ecletica-329	91	4	total	total	ADJ
ecletica-329	91	5	bond	bond	NOUN
ecletica-329	91	6	energy	energy	NOUN
ecletica-329	91	7	between	between	ADP
ecletica-329	91	8	ligands	ligand	NOUN
ecletica-329	91	9	and	and	CCONJ
ecletica-329	91	10	collagenase	collagenase	NOUN
ecletica-329	91	11	of	of	ADP
ecletica-329	91	12	clostridium	clostridium	NOUN
ecletica-329	91	13	histolyticum	histolyticum	NOUN
ecletica-329	91	14	.	.	PUNCT
ecletica-329	92	1	ligands	ligand	NOUN
ecletica-329	92	2	meloxicam	meloxicam	PROPN
ecletica-329	92	3	tenoxicam	tenoxicam	PROPN
ecletica-329	92	4	piroxicam	piroxicam	PROPN
ecletica-329	92	5	alendronate	alendronate	PROPN
ecletica-329	92	6	doxycycline	doxycycline	NOUN
ecletica-329	92	7	bond	bond	NOUN
ecletica-329	92	8	energy	energy	NOUN
ecletica-329	92	9	enzyme	enzyme	NOUN
ecletica-329	92	10	-	-	PUNCT
ecletica-329	92	11	ligand	ligand	NOUN
ecletica-329	92	12	(	(	PUNCT
ecletica-329	92	13	hartree	hartree	NOUN
ecletica-329	92	14	)	)	PUNCT
ecletica-329	92	15	-0,186001	-0,186001	PROPN
ecletica-329	93	1	-0,200768	-0,200768	NOUN
ecletica-329	94	1	-0,210681	-0,210681	INTJ
ecletica-329	94	2	-0,428059	-0,428059	NOUN
ecletica-329	95	1	-0,189599	-0,189599	NUM
ecletica-329	95	2	bigger	big	ADJ
ecletica-329	95	3	bond	bond	NOUN
ecletica-329	95	4	energy	energy	NOUN
ecletica-329	95	5	means	mean	VERB
ecletica-329	95	6	a	a	DET
ecletica-329	95	7	stronger	strong	ADJ
ecletica-329	95	8	interaction	interaction	NOUN
ecletica-329	95	9	between	between	ADP
ecletica-329	95	10	ligand	ligand	NOUN
ecletica-329	95	11	and	and	CCONJ
ecletica-329	95	12	enzyme	enzyme	NOUN
ecletica-329	95	13	,	,	PUNCT
ecletica-329	95	14	but	but	CCONJ
ecletica-329	95	15	does	do	AUX
ecletica-329	95	16	not	not	PART
ecletica-329	95	17	mean	mean	VERB
ecletica-329	95	18	that	that	SCONJ
ecletica-329	95	19	this	this	DET
ecletica-329	95	20	ligand	ligand	NOUN
ecletica-329	95	21	is	be	AUX
ecletica-329	95	22	a	a	DET
ecletica-329	95	23	better	well	ADJ
ecletica-329	95	24	inhibitor	inhibitor	NOUN
ecletica-329	95	25	,	,	PUNCT
ecletica-329	95	26	because	because	SCONJ
ecletica-329	95	27	this	this	DET
ecletica-329	95	28	property	property	NOUN
ecletica-329	95	29	depends	depend	VERB
ecletica-329	95	30	on	on	ADP
ecletica-329	95	31	the	the	DET
ecletica-329	95	32	nature	nature	NOUN
ecletica-329	95	33	of	of	ADP
ecletica-329	95	34	the	the	DET
ecletica-329	95	35	interaction	interaction	NOUN
ecletica-329	95	36	and	and	CCONJ
ecletica-329	95	37	the	the	DET
ecletica-329	95	38	groups	group	NOUN
ecletica-329	95	39	involved	involve	VERB
ecletica-329	95	40	.	.	PUNCT
ecletica-329	96	1	outstanding	outstanding	ADJ
ecletica-329	96	2	example	example	NOUN
ecletica-329	96	3	in	in	ADP
ecletica-329	96	4	this	this	DET
ecletica-329	96	5	group	group	NOUN
ecletica-329	96	6	is	be	AUX
ecletica-329	96	7	aleneq06	aleneq06	NOUN
ecletica-329	96	8	-	-	PUNCT
ecletica-329	96	9	af	af	PROPN
ecletica-329	96	10	4/12/08	4/12/08	NUM
ecletica-329	96	11	9:55	9:55	NUM
ecletica-329	96	12	page	page	NOUN
ecletica-329	96	13	50	50	NUM
ecletica-329	96	14	dronate	dronate	NOUN
ecletica-329	96	15	:	:	PUNCT
ecletica-329	96	16	the	the	DET
ecletica-329	96	17	worst	bad	ADJ
ecletica-329	96	18	inhibitor	inhibitor	NOUN
ecletica-329	96	19	(	(	PUNCT
ecletica-329	96	20	actually	actually	ADV
ecletica-329	96	21	an	an	DET
ecletica-329	96	22	activator	activator	NOUN
ecletica-329	96	23	)	)	PUNCT
ecletica-329	96	24	is	be	AUX
ecletica-329	96	25	the	the	DET
ecletica-329	96	26	molecule	molecule	NOUN
ecletica-329	96	27	that	that	PRON
ecletica-329	96	28	interacts	interact	VERB
ecletica-329	96	29	more	more	ADV
ecletica-329	96	30	strongly	strongly	ADV
ecletica-329	96	31	with	with	ADP
ecletica-329	96	32	the	the	DET
ecletica-329	96	33	enzyme	enzyme	NOUN
ecletica-329	96	34	.	.	PUNCT
ecletica-329	97	1	on	on	ADP
ecletica-329	97	2	the	the	DET
ecletica-329	97	3	other	other	ADJ
ecletica-329	97	4	hand	hand	NOUN
ecletica-329	97	5	,	,	PUNCT
ecletica-329	97	6	when	when	SCONJ
ecletica-329	97	7	similar	similar	ADJ
ecletica-329	97	8	molecules	molecule	NOUN
ecletica-329	97	9	are	be	AUX
ecletica-329	97	10	compared	compare	VERB
ecletica-329	97	11	,	,	PUNCT
ecletica-329	97	12	as	as	ADP
ecletica-329	97	13	the	the	DET
ecletica-329	97	14	oxicans	oxican	NOUN
ecletica-329	97	15	,	,	PUNCT
ecletica-329	97	16	we	we	PRON
ecletica-329	97	17	see	see	VERB
ecletica-329	97	18	that	that	DET
ecletica-329	97	19	piroxicam	piroxicam	NOUN
ecletica-329	97	20	is	be	AUX
ecletica-329	97	21	the	the	DET
ecletica-329	97	22	best	good	ADJ
ecletica-329	97	23	inhibitor	inhibitor	NOUN
ecletica-329	97	24	and	and	CCONJ
ecletica-329	97	25	the	the	DET
ecletica-329	97	26	more	more	ADV
ecletica-329	97	27	strongly	strongly	ADV
ecletica-329	97	28	bonding	bonding	NOUN
ecletica-329	97	29	to	to	ADP
ecletica-329	97	30	the	the	DET
ecletica-329	97	31	enzyme	enzyme	NOUN
ecletica-329	97	32	.	.	PUNCT
ecletica-329	98	1	the	the	DET
ecletica-329	98	2	conclusion	conclusion	NOUN
ecletica-329	98	3	is	be	AUX
ecletica-329	98	4	:	:	PUNCT
ecletica-329	98	5	first	first	ADV
ecletica-329	98	6	it	it	PRON
ecletica-329	98	7	is	be	AUX
ecletica-329	98	8	necessary	necessary	ADJ
ecletica-329	98	9	to	to	PART
ecletica-329	98	10	find	find	VERB
ecletica-329	98	11	the	the	DET
ecletica-329	98	12	species	specie	NOUN
ecletica-329	98	13	that	that	PRON
ecletica-329	98	14	interact	interact	VERB
ecletica-329	98	15	more	more	ADV
ecletica-329	98	16	favorably	favorably	ADV
ecletica-329	98	17	regarding	regard	VERB
ecletica-329	98	18	the	the	DET
ecletica-329	98	19	expected	expect	VERB
ecletica-329	98	20	effect	effect	NOUN
ecletica-329	98	21	.	.	PUNCT
ecletica-329	99	1	once	once	ADV
ecletica-329	99	2	found	find	VERB
ecletica-329	99	3	a	a	DET
ecletica-329	99	4	substance	substance	NOUN
ecletica-329	99	5	like	like	ADP
ecletica-329	99	6	this	this	PRON
ecletica-329	99	7	,	,	PUNCT
ecletica-329	99	8	its	its	PRON
ecletica-329	99	9	structure	structure	NOUN
ecletica-329	99	10	must	must	AUX
ecletica-329	99	11	be	be	AUX
ecletica-329	99	12	modified	modify	VERB
ecletica-329	99	13	seeking	seek	VERB
ecletica-329	99	14	to	to	PART
ecletica-329	99	15	obtain	obtain	VERB
ecletica-329	99	16	a	a	DET
ecletica-329	99	17	stronger	strong	ADJ
ecletica-329	99	18	interaction	interaction	NOUN
ecletica-329	99	19	that	that	PRON
ecletica-329	99	20	intensifies	intensify	VERB
ecletica-329	99	21	such	such	ADJ
ecletica-329	99	22	effect	effect	NOUN
ecletica-329	99	23	.	.	PUNCT
ecletica-329	100	1	the	the	DET
ecletica-329	100	2	definition	definition	NOUN
ecletica-329	100	3	of	of	ADP
ecletica-329	100	4	which	which	PRON
ecletica-329	100	5	interactions	interaction	NOUN
ecletica-329	100	6	are	be	AUX
ecletica-329	100	7	favorable	favorable	ADJ
ecletica-329	100	8	to	to	ADP
ecletica-329	100	9	the	the	DET
ecletica-329	100	10	inhibiting	inhibit	VERB
ecletica-329	100	11	effect	effect	NOUN
ecletica-329	100	12	depends	depend	VERB
ecletica-329	100	13	on	on	ADP
ecletica-329	100	14	the	the	DET
ecletica-329	100	15	knowledge	knowledge	NOUN
ecletica-329	100	16	of	of	ADP
ecletica-329	100	17	which	which	DET
ecletica-329	100	18	groups	group	NOUN
ecletica-329	100	19	of	of	ADP
ecletica-329	100	20	the	the	DET
ecletica-329	100	21	active	active	ADJ
ecletica-329	100	22	site	site	NOUN
ecletica-329	100	23	are	be	AUX
ecletica-329	100	24	important	important	ADJ
ecletica-329	100	25	for	for	ADP
ecletica-329	100	26	the	the	DET
ecletica-329	100	27	enzymatic	enzymatic	ADJ
ecletica-329	100	28	activity	activity	NOUN
ecletica-329	100	29	.	.	PUNCT
ecletica-329	101	1	in	in	ADP
ecletica-329	101	2	the	the	DET
ecletica-329	101	3	case	case	NOUN
ecletica-329	101	4	of	of	ADP
ecletica-329	101	5	clostridium	clostridium	NOUN
ecletica-329	101	6	histolyticum	histolyticum	PROPN
ecletica-329	101	7	collagenase	collagenase	NOUN
ecletica-329	101	8	,	,	PUNCT
ecletica-329	101	9	wilson	wilson	PROPN
ecletica-329	101	10	et	et	PROPN
ecletica-329	101	11	al	al	PROPN
ecletica-329	101	12	.	.	PUNCT
ecletica-329	102	1	[	[	X
ecletica-329	102	2	13	13	NUM
ecletica-329	102	3	]	]	PUNCT
ecletica-329	102	4	identified	identify	VERB
ecletica-329	102	5	the	the	DET
ecletica-329	102	6	amino	amino	NOUN
ecletica-329	102	7	acids	acid	NOUN
ecletica-329	102	8	residues	residue	NOUN
ecletica-329	102	9	relevant	relevant	ADJ
ecletica-329	102	10	for	for	ADP
ecletica-329	102	11	the	the	DET
ecletica-329	102	12	enzymatic	enzymatic	ADJ
ecletica-329	102	13	activity	activity	NOUN
ecletica-329	102	14	,	,	PUNCT
ecletica-329	102	15	through	through	ADP
ecletica-329	102	16	the	the	DET
ecletica-329	102	17	analysis	analysis	NOUN
ecletica-329	102	18	of	of	ADP
ecletica-329	102	19	the	the	DET
ecletica-329	102	20	mutagenesis	mutagenesis	NOUN
ecletica-329	102	21	effect	effect	NOUN
ecletica-329	102	22	of	of	ADP
ecletica-329	102	23	each	each	DET
ecletica-329	102	24	residue	residue	NOUN
ecletica-329	102	25	upon	upon	SCONJ
ecletica-329	102	26	such	such	ADJ
ecletica-329	102	27	activity	activity	NOUN
ecletica-329	102	28	.	.	PUNCT
ecletica-329	103	1	the	the	DET
ecletica-329	103	2	authors	author	NOUN
ecletica-329	103	3	concluded	conclude	VERB
ecletica-329	103	4	that	that	SCONJ
ecletica-329	103	5	:	:	PUNCT
ecletica-329	103	6	1	1	X
ecletica-329	103	7	.	.	X
ecletica-329	103	8	thr957	thr957	NOUN
ecletica-329	103	9	,	,	PUNCT
ecletica-329	103	10	tyr970	tyr970	PROPN
ecletica-329	103	11	,	,	PUNCT
ecletica-329	103	12	leu992	leu992	PROPN
ecletica-329	103	13	,	,	PUNCT
ecletica-329	103	14	tyr994	tyr994	NOUN
ecletica-329	103	15	e	e	NOUN
ecletica-329	103	16	tyr996	tyr996	PROPN
ecletica-329	103	17	amino	amino	ADJ
ecletica-329	103	18	acids	acid	NOUN
ecletica-329	103	19	residues	residue	NOUN
ecletica-329	103	20	are	be	AUX
ecletica-329	103	21	very	very	ADV
ecletica-329	103	22	important	important	ADJ
ecletica-329	103	23	for	for	ADP
ecletica-329	103	24	the	the	DET
ecletica-329	103	25	bond	bond	NOUN
ecletica-329	103	26	with	with	ADP
ecletica-329	103	27	collagen	collagen	NOUN
ecletica-329	103	28	(	(	PUNCT
ecletica-329	103	29	tyr994	tyr994	NOUN
ecletica-329	103	30	is	be	AUX
ecletica-329	103	31	probably	probably	ADV
ecletica-329	103	32	the	the	DET
ecletica-329	103	33	most	most	ADV
ecletica-329	103	34	important	important	ADJ
ecletica-329	103	35	:	:	PUNCT
ecletica-329	103	36	its	its	PRON
ecletica-329	103	37	substitution	substitution	NOUN
ecletica-329	103	38	reduces	reduce	VERB
ecletica-329	103	39	the	the	DET
ecletica-329	103	40	activity	activity	NOUN
ecletica-329	103	41	in	in	ADP
ecletica-329	103	42	more	more	ADJ
ecletica-329	103	43	than	than	ADP
ecletica-329	103	44	5	5	NUM
ecletica-329	103	45	times	time	NOUN
ecletica-329	103	46	)	)	PUNCT
ecletica-329	103	47	.	.	PUNCT
ecletica-329	104	1	2	2	X
ecletica-329	104	2	.	.	X
ecletica-329	104	3	tyr990	tyr990	NOUN
ecletica-329	104	4	,	,	PUNCT
ecletica-329	104	5	tyr931	tyr931	ADV
ecletica-329	104	6	,	,	PUNCT
ecletica-329	104	7	tyr932	tyr932	PRON
ecletica-329	104	8	,	,	PUNCT
ecletica-329	104	9	asp966	asp966	PROPN
ecletica-329	104	10	e	e	PROPN
ecletica-329	104	11	asp974	asp974	PROPN
ecletica-329	104	12	are	be	AUX
ecletica-329	104	13	less	less	ADV
ecletica-329	104	14	important	important	ADJ
ecletica-329	104	15	,	,	PUNCT
ecletica-329	104	16	because	because	SCONJ
ecletica-329	104	17	their	their	PRON
ecletica-329	104	18	loss	loss	NOUN
ecletica-329	104	19	or	or	CCONJ
ecletica-329	104	20	blockade	blockade	NOUN
ecletica-329	104	21	have	have	VERB
ecletica-329	104	22	a	a	DET
ecletica-329	104	23	small	small	ADJ
ecletica-329	104	24	inhibition	inhibition	NOUN
ecletica-329	104	25	effect	effect	NOUN
ecletica-329	104	26	.	.	PUNCT
ecletica-329	105	1	3	3	X
ecletica-329	105	2	.	.	X
ecletica-329	105	3	his959	his959	NOUN
ecletica-329	105	4	interacts	interact	VERB
ecletica-329	105	5	with	with	ADP
ecletica-329	105	6	only	only	ADV
ecletica-329	105	7	one	one	NUM
ecletica-329	105	8	of	of	ADP
ecletica-329	105	9	the	the	DET
ecletica-329	105	10	four	four	NUM
ecletica-329	105	11	collagen	collagen	NOUN
ecletica-329	105	12	orientations	orientation	NOUN
ecletica-329	105	13	proposed	propose	VERB
ecletica-329	105	14	by	by	ADP
ecletica-329	105	15	the	the	DET
ecletica-329	105	16	authors	author	NOUN
ecletica-329	105	17	.	.	PUNCT
ecletica-329	106	1	4	4	X
ecletica-329	106	2	.	.	X
ecletica-329	106	3	arg929	arg929	NOUN
ecletica-329	106	4	mutation	mutation	NOUN
ecletica-329	106	5	intensifies	intensify	VERB
ecletica-329	106	6	the	the	DET
ecletica-329	106	7	bonding	bonding	NOUN
ecletica-329	106	8	with	with	ADP
ecletica-329	106	9	collagen	collagen	NOUN
ecletica-329	106	10	.	.	PUNCT
ecletica-329	107	1	based	base	VERB
ecletica-329	107	2	on	on	ADP
ecletica-329	107	3	these	these	DET
ecletica-329	107	4	conclusions	conclusion	NOUN
ecletica-329	107	5	,	,	PUNCT
ecletica-329	107	6	we	we	PRON
ecletica-329	107	7	can	can	AUX
ecletica-329	107	8	discuss	discuss	VERB
ecletica-329	107	9	the	the	DET
ecletica-329	107	10	experimental	experimental	ADJ
ecletica-329	107	11	results	result	NOUN
ecletica-329	107	12	regarding	regard	VERB
ecletica-329	107	13	docking	dock	VERB
ecletica-329	107	14	calculations	calculation	NOUN
ecletica-329	107	15	.	.	PUNCT
ecletica-329	108	1	initially	initially	ADV
ecletica-329	108	2	consider	consider	VERB
ecletica-329	108	3	the	the	DET
ecletica-329	108	4	oxicans	oxicans	PROPN
ecletica-329	108	5	series	series	PROPN
ecletica-329	108	6	:	:	PUNCT
ecletica-329	108	7	piroxicam	piroxicam	ADJ
ecletica-329	108	8	,	,	PUNCT
ecletica-329	108	9	tenoxicam	tenoxicam	NOUN
ecletica-329	108	10	and	and	CCONJ
ecletica-329	108	11	meloxicam	meloxicam	NOUN
ecletica-329	108	12	.	.	PUNCT
ecletica-329	109	1	the	the	DET
ecletica-329	109	2	experiments	experiment	NOUN
ecletica-329	109	3	show	show	VERB
ecletica-329	109	4	that	that	SCONJ
ecletica-329	109	5	the	the	DET
ecletica-329	109	6	inhibiting	inhibit	VERB
ecletica-329	109	7	effect	effect	NOUN
ecletica-329	109	8	on	on	ADP
ecletica-329	109	9	bacterial	bacterial	ADJ
ecletica-329	109	10	collagenase	collagenase	NOUN
ecletica-329	109	11	decreases	decrease	VERB
ecletica-329	109	12	from	from	ADP
ecletica-329	109	13	piroxicam	piroxicam	PROPN
ecletica-329	109	14	to	to	PART
ecletica-329	109	15	meloxicam	meloxicam	VERB
ecletica-329	109	16	.	.	PUNCT
ecletica-329	110	1	according	accord	VERB
ecletica-329	110	2	to	to	ADP
ecletica-329	110	3	table	table	NOUN
ecletica-329	110	4	2	2	NUM
ecletica-329	110	5	,	,	PUNCT
ecletica-329	110	6	total	total	ADJ
ecletica-329	110	7	interaction	interaction	NOUN
ecletica-329	110	8	energy	energy	NOUN
ecletica-329	110	9	follows	follow	VERB
ecletica-329	110	10	the	the	DET
ecletica-329	110	11	exact	exact	ADJ
ecletica-329	110	12	sequence	sequence	NOUN
ecletica-329	110	13	above	above	ADV
ecletica-329	110	14	:	:	PUNCT
ecletica-329	110	15	the	the	DET
ecletica-329	110	16	more	more	ADV
ecletica-329	110	17	negative	negative	ADJ
ecletica-329	110	18	figure	figure	NOUN
ecletica-329	110	19	(	(	PUNCT
ecletica-329	110	20	stronger	strong	ADJ
ecletica-329	110	21	global	global	ADJ
ecletica-329	110	22	interaction	interaction	NOUN
ecletica-329	110	23	)	)	PUNCT
ecletica-329	110	24	is	be	AUX
ecletica-329	110	25	that	that	PRON
ecletica-329	110	26	of	of	ADP
ecletica-329	110	27	piroxicam	piroxicam	NOUN
ecletica-329	110	28	,	,	PUNCT
ecletica-329	110	29	following	follow	VERB
ecletica-329	110	30	by	by	ADP
ecletica-329	110	31	tenoxicam	tenoxicam	NOUN
ecletica-329	110	32	and	and	CCONJ
ecletica-329	110	33	meloxicam	meloxicam	PROPN
ecletica-329	110	34	bond	bond	NOUN
ecletica-329	110	35	energies	energy	NOUN
ecletica-329	110	36	.	.	PUNCT
ecletica-329	111	1	concerning	concern	VERB
ecletica-329	111	2	the	the	DET
ecletica-329	111	3	amino	amino	ADJ
ecletica-329	111	4	acids	acid	NOUN
ecletica-329	111	5	residues	residue	NOUN
ecletica-329	111	6	that	that	PRON
ecletica-329	111	7	interact	interact	VERB
ecletica-329	111	8	with	with	ADP
ecletica-329	111	9	the	the	DET
ecletica-329	111	10	oxicans	oxican	NOUN
ecletica-329	111	11	,	,	PUNCT
ecletica-329	111	12	first	first	ADV
ecletica-329	111	13	,	,	PUNCT
ecletica-329	111	14	the	the	DET
ecletica-329	111	15	piroxicam	piroxicam	NOUN
ecletica-329	111	16	,	,	PUNCT
ecletica-329	111	17	although	although	SCONJ
ecletica-329	111	18	it	it	PRON
ecletica-329	111	19	forms	form	VERB
ecletica-329	111	20	three	three	NUM
ecletica-329	111	21	hydrogen	hydrogen	NOUN
ecletica-329	111	22	51ecl	51ecl	NOUN
ecletica-329	111	23	.	.	PUNCT
ecletica-329	112	1	quím	quím	PROPN
ecletica-329	112	2	.	.	PUNCT
ecletica-329	112	3	,	,	PUNCT
ecletica-329	112	4	são	são	PROPN
ecletica-329	112	5	paulo	paulo	PROPN
ecletica-329	112	6	,	,	PUNCT
ecletica-329	112	7	33(4	33(4	NUM
ecletica-329	112	8	):	):	PUNCT
ecletica-329	112	9	47	47	NUM
ecletica-329	112	10	-	-	SYM
ecletica-329	112	11	52	52	NUM
ecletica-329	112	12	,	,	PUNCT
ecletica-329	112	13	2008	2008	NUM
ecletica-329	112	14	bonds	bond	NOUN
ecletica-329	112	15	with	with	ADP
ecletica-329	112	16	arg929	arg929	NOUN
ecletica-329	112	17	,	,	PUNCT
ecletica-329	112	18	whose	whose	DET
ecletica-329	112	19	blockade	blockade	NOUN
ecletica-329	112	20	is	be	AUX
ecletica-329	112	21	activator	activator	NOUN
ecletica-329	112	22	,	,	PUNCT
ecletica-329	112	23	it	it	PRON
ecletica-329	112	24	is	be	AUX
ecletica-329	112	25	the	the	DET
ecletica-329	112	26	only	only	ADJ
ecletica-329	112	27	of	of	ADP
ecletica-329	112	28	the	the	DET
ecletica-329	112	29	oxicans	oxicans	PROPN
ecletica-329	112	30	tested	test	VERB
ecletica-329	112	31	that	that	SCONJ
ecletica-329	112	32	bonds	bond	NOUN
ecletica-329	112	33	to	to	ADP
ecletica-329	112	34	two	two	NUM
ecletica-329	112	35	groups	group	NOUN
ecletica-329	112	36	of	of	ADP
ecletica-329	112	37	relevance	relevance	NOUN
ecletica-329	112	38	for	for	ADP
ecletica-329	112	39	the	the	DET
ecletica-329	112	40	interaction	interaction	NOUN
ecletica-329	112	41	enzyme	enzyme	NOUN
ecletica-329	112	42	-	-	PUNCT
ecletica-329	112	43	substratum	substratum	NOUN
ecletica-329	112	44	,	,	PUNCT
ecletica-329	112	45	what	what	PRON
ecletica-329	112	46	should	should	AUX
ecletica-329	112	47	generate	generate	VERB
ecletica-329	112	48	a	a	DET
ecletica-329	112	49	more	more	ADV
ecletica-329	112	50	efficient	efficient	ADJ
ecletica-329	112	51	blockade	blockade	NOUN
ecletica-329	112	52	to	to	ADP
ecletica-329	112	53	the	the	DET
ecletica-329	112	54	approach	approach	NOUN
ecletica-329	112	55	and	and	CCONJ
ecletica-329	112	56	interaction	interaction	NOUN
ecletica-329	112	57	of	of	ADP
ecletica-329	112	58	the	the	DET
ecletica-329	112	59	enzyme	enzyme	NOUN
ecletica-329	112	60	with	with	ADP
ecletica-329	112	61	collagen	collagen	NOUN
ecletica-329	112	62	.	.	PUNCT
ecletica-329	113	1	tenoxicam	tenoxicam	PROPN
ecletica-329	113	2	and	and	CCONJ
ecletica-329	113	3	meloxicam	meloxicam	PROPN
ecletica-329	113	4	bond	bond	NOUN
ecletica-329	113	5	to	to	ADP
ecletica-329	113	6	arg929	arg929	X
ecletica-329	113	7	too	too	ADV
ecletica-329	113	8	and	and	CCONJ
ecletica-329	113	9	each	each	DET
ecletica-329	113	10	one	one	NOUN
ecletica-329	113	11	to	to	ADP
ecletica-329	113	12	a	a	DET
ecletica-329	113	13	second	second	ADJ
ecletica-329	113	14	relevant	relevant	ADJ
ecletica-329	113	15	group	group	NOUN
ecletica-329	113	16	for	for	ADP
ecletica-329	113	17	enzyme	enzyme	NOUN
ecletica-329	113	18	activity	activity	NOUN
ecletica-329	113	19	:	:	PUNCT
ecletica-329	113	20	tyr931	tyr931	ADV
ecletica-329	113	21	with	with	ADP
ecletica-329	113	22	tenoxicam	tenoxicam	NOUN
ecletica-329	113	23	and	and	CCONJ
ecletica-329	113	24	thr957	thr957	VERB
ecletica-329	113	25	with	with	ADP
ecletica-329	113	26	meloxicam	meloxicam	NOUN
ecletica-329	113	27	.	.	PUNCT
ecletica-329	114	1	however	however	ADV
ecletica-329	114	2	,	,	PUNCT
ecletica-329	114	3	meloxicam	meloxicam	PROPN
ecletica-329	114	4	bonds	bond	VERB
ecletica-329	114	5	much	much	ADV
ecletica-329	114	6	more	more	ADV
ecletica-329	114	7	strongly	strongly	ADV
ecletica-329	114	8	to	to	ADP
ecletica-329	114	9	arg929	arg929	PROPN
ecletica-329	114	10	(	(	PUNCT
ecletica-329	114	11	three	three	NUM
ecletica-329	114	12	hydrogen	hydrogen	NOUN
ecletica-329	114	13	bonds	bond	NOUN
ecletica-329	114	14	)	)	PUNCT
ecletica-329	114	15	than	than	ADP
ecletica-329	114	16	tenoxicam	tenoxicam	NOUN
ecletica-329	114	17	(	(	PUNCT
ecletica-329	114	18	only	only	ADV
ecletica-329	114	19	one	one	NUM
ecletica-329	114	20	)	)	PUNCT
ecletica-329	114	21	,	,	PUNCT
ecletica-329	114	22	residue	residue	NOUN
ecletica-329	114	23	whose	whose	DET
ecletica-329	114	24	blockade	blockade	NOUN
ecletica-329	114	25	is	be	AUX
ecletica-329	114	26	stimulating	stimulate	VERB
ecletica-329	114	27	for	for	ADP
ecletica-329	114	28	the	the	DET
ecletica-329	114	29	activity	activity	NOUN
ecletica-329	114	30	,	,	PUNCT
ecletica-329	114	31	what	what	PRON
ecletica-329	114	32	can	can	AUX
ecletica-329	114	33	explain	explain	VERB
ecletica-329	114	34	the	the	DET
ecletica-329	114	35	complete	complete	ADJ
ecletica-329	114	36	absence	absence	NOUN
ecletica-329	114	37	of	of	ADP
ecletica-329	114	38	inhibiting	inhibit	VERB
ecletica-329	114	39	effect	effect	NOUN
ecletica-329	114	40	in	in	ADP
ecletica-329	114	41	the	the	DET
ecletica-329	114	42	case	case	NOUN
ecletica-329	114	43	of	of	ADP
ecletica-329	114	44	meloxicam	meloxicam	NOUN
ecletica-329	114	45	.	.	PUNCT
ecletica-329	115	1	concerning	concern	VERB
ecletica-329	115	2	the	the	DET
ecletica-329	115	3	tested	test	VERB
ecletica-329	115	4	tetracyclines	tetracycline	NOUN
ecletica-329	115	5	,	,	PUNCT
ecletica-329	115	6	it	it	PRON
ecletica-329	115	7	was	be	AUX
ecletica-329	115	8	possible	possible	ADJ
ecletica-329	115	9	to	to	PART
ecletica-329	115	10	simulate	simulate	VERB
ecletica-329	115	11	the	the	DET
ecletica-329	115	12	docking	docking	NOUN
ecletica-329	115	13	only	only	ADV
ecletica-329	115	14	with	with	ADP
ecletica-329	115	15	the	the	DET
ecletica-329	115	16	doxycycline	doxycycline	NOUN
ecletica-329	115	17	,	,	PUNCT
ecletica-329	115	18	because	because	SCONJ
ecletica-329	115	19	the	the	DET
ecletica-329	115	20	calculation	calculation	NOUN
ecletica-329	115	21	with	with	ADP
ecletica-329	115	22	tetracycline	tetracycline	NOUN
ecletica-329	115	23	did	do	AUX
ecletica-329	115	24	not	not	PART
ecletica-329	115	25	result	result	VERB
ecletica-329	115	26	in	in	ADP
ecletica-329	115	27	any	any	DET
ecletica-329	115	28	favorable	favorable	ADJ
ecletica-329	115	29	interaction	interaction	NOUN
ecletica-329	115	30	.	.	PUNCT
ecletica-329	116	1	the	the	DET
ecletica-329	116	2	calculated	calculate	VERB
ecletica-329	116	3	bond	bond	NOUN
ecletica-329	116	4	energy	energy	NOUN
ecletica-329	116	5	for	for	ADP
ecletica-329	116	6	doxycycline	doxycycline	NOUN
ecletica-329	116	7	-	-	PUNCT
ecletica-329	116	8	enzyme	enzyme	NOUN
ecletica-329	116	9	is	be	AUX
ecletica-329	116	10	similar	similar	ADJ
ecletica-329	116	11	to	to	ADP
ecletica-329	116	12	that	that	PRON
ecletica-329	116	13	of	of	ADP
ecletica-329	116	14	meloxicamenzyme	meloxicamenzyme	NOUN
ecletica-329	116	15	(	(	PUNCT
ecletica-329	116	16	table	table	NOUN
ecletica-329	116	17	2	2	NUM
ecletica-329	116	18	)	)	PUNCT
ecletica-329	116	19	.	.	PUNCT
ecletica-329	117	1	the	the	DET
ecletica-329	117	2	hydrogen	hydrogen	NOUN
ecletica-329	117	3	bonds	bond	NOUN
ecletica-329	117	4	between	between	ADP
ecletica-329	117	5	each	each	DET
ecletica-329	117	6	ligand	ligand	NOUN
ecletica-329	117	7	and	and	CCONJ
ecletica-329	117	8	the	the	DET
ecletica-329	117	9	collagenase	collagenase	NOUN
ecletica-329	117	10	have	have	VERB
ecletica-329	117	11	much	much	ADJ
ecletica-329	117	12	in	in	ADP
ecletica-329	117	13	common	common	ADJ
ecletica-329	117	14	,	,	PUNCT
ecletica-329	117	15	namely	namely	ADV
ecletica-329	117	16	,	,	PUNCT
ecletica-329	117	17	both	both	DET
ecletica-329	117	18	bond	bond	NOUN
ecletica-329	117	19	to	to	ADP
ecletica-329	117	20	arg929	arg929	NOUN
ecletica-329	117	21	,	,	PUNCT
ecletica-329	117	22	residue	residue	NOUN
ecletica-329	117	23	whose	whose	DET
ecletica-329	117	24	blockade	blockade	NOUN
ecletica-329	117	25	is	be	AUX
ecletica-329	117	26	activator	activator	NOUN
ecletica-329	117	27	for	for	ADP
ecletica-329	117	28	the	the	DET
ecletica-329	117	29	enzyme	enzyme	NOUN
ecletica-329	117	30	,	,	PUNCT
ecletica-329	117	31	meloxicam	meloxicam	NOUN
ecletica-329	117	32	by	by	ADP
ecletica-329	117	33	three	three	NUM
ecletica-329	117	34	hydrogen	hydrogen	NOUN
ecletica-329	117	35	bonds	bond	NOUN
ecletica-329	117	36	and	and	CCONJ
ecletica-329	117	37	doxycycline	doxycycline	VERB
ecletica-329	117	38	through	through	ADP
ecletica-329	117	39	two	two	NUM
ecletica-329	117	40	.	.	PUNCT
ecletica-329	118	1	on	on	ADP
ecletica-329	118	2	the	the	DET
ecletica-329	118	3	other	other	ADJ
ecletica-329	118	4	side	side	NOUN
ecletica-329	118	5	,	,	PUNCT
ecletica-329	118	6	both	both	PRON
ecletica-329	118	7	bond	bond	NOUN
ecletica-329	118	8	to	to	ADP
ecletica-329	118	9	one	one	NUM
ecletica-329	118	10	residue	residue	NOUN
ecletica-329	118	11	whose	whose	DET
ecletica-329	118	12	blockade	blockade	NOUN
ecletica-329	118	13	is	be	AUX
ecletica-329	118	14	inhibitor	inhibitor	NOUN
ecletica-329	118	15	:	:	PUNCT
ecletica-329	118	16	thr957	thr957	NOUN
ecletica-329	118	17	for	for	ADP
ecletica-329	118	18	meloxicam	meloxicam	NOUN
ecletica-329	118	19	and	and	CCONJ
ecletica-329	118	20	asp966	asp966	PROPN
ecletica-329	118	21	for	for	ADP
ecletica-329	118	22	doxycycline	doxycycline	NOUN
ecletica-329	118	23	.	.	PUNCT
ecletica-329	119	1	the	the	DET
ecletica-329	119	2	former	former	NOUN
ecletica-329	119	3	has	have	VERB
ecletica-329	119	4	a	a	DET
ecletica-329	119	5	more	more	ADV
ecletica-329	119	6	intense	intense	ADJ
ecletica-329	119	7	influence	influence	NOUN
ecletica-329	119	8	upon	upon	SCONJ
ecletica-329	119	9	the	the	DET
ecletica-329	119	10	inhibition	inhibition	NOUN
ecletica-329	119	11	of	of	ADP
ecletica-329	119	12	the	the	DET
ecletica-329	119	13	enzyme	enzyme	NOUN
ecletica-329	119	14	than	than	ADP
ecletica-329	119	15	the	the	DET
ecletica-329	119	16	second	second	ADJ
ecletica-329	119	17	,	,	PUNCT
ecletica-329	119	18	what	what	PRON
ecletica-329	119	19	should	should	AUX
ecletica-329	119	20	compensate	compensate	VERB
ecletica-329	119	21	the	the	DET
ecletica-329	119	22	stronger	strong	ADJ
ecletica-329	119	23	interaction	interaction	NOUN
ecletica-329	119	24	of	of	ADP
ecletica-329	119	25	meloxicam	meloxicam	NOUN
ecletica-329	119	26	with	with	ADP
ecletica-329	119	27	arg929	arg929	NOUN
ecletica-329	119	28	and	and	CCONJ
ecletica-329	119	29	to	to	PART
ecletica-329	119	30	result	result	VERB
ecletica-329	119	31	in	in	ADP
ecletica-329	119	32	a	a	DET
ecletica-329	119	33	similar	similar	ADJ
ecletica-329	119	34	effect	effect	NOUN
ecletica-329	119	35	comparatively	comparatively	ADV
ecletica-329	119	36	to	to	ADP
ecletica-329	119	37	doxycycline	doxycycline	VERB
ecletica-329	119	38	.	.	PUNCT
ecletica-329	120	1	finally	finally	ADV
ecletica-329	120	2	,	,	PUNCT
ecletica-329	120	3	alendronate	alendronate	PROPN
ecletica-329	120	4	forms	form	VERB
ecletica-329	120	5	two	two	NUM
ecletica-329	120	6	hydrogen	hydrogen	NOUN
ecletica-329	120	7	bonds	bond	NOUN
ecletica-329	120	8	with	with	ADP
ecletica-329	120	9	arg929	arg929	NOUN
ecletica-329	120	10	and	and	CCONJ
ecletica-329	120	11	one	one	NUM
ecletica-329	120	12	with	with	ADP
ecletica-329	120	13	tyr931	tyr931	ADV
ecletica-329	120	14	,	,	PUNCT
ecletica-329	120	15	residue	residue	NOUN
ecletica-329	120	16	whose	whose	DET
ecletica-329	120	17	suppression	suppression	NOUN
ecletica-329	120	18	has	have	VERB
ecletica-329	120	19	very	very	ADV
ecletica-329	120	20	little	little	ADJ
ecletica-329	120	21	inhibiting	inhibit	VERB
ecletica-329	120	22	effect	effect	NOUN
ecletica-329	120	23	.	.	PUNCT
ecletica-329	121	1	probably	probably	ADV
ecletica-329	121	2	the	the	DET
ecletica-329	121	3	strong	strong	ADJ
ecletica-329	121	4	bond	bond	NOUN
ecletica-329	121	5	energy	energy	NOUN
ecletica-329	121	6	alendronate	alendronate	NOUN
ecletica-329	121	7	-	-	PUNCT
ecletica-329	121	8	collagenase	collagenase	NOUN
ecletica-329	121	9	translates	translate	VERB
ecletica-329	121	10	a	a	DET
ecletica-329	121	11	very	very	ADV
ecletica-329	121	12	strong	strong	ADJ
ecletica-329	121	13	interaction	interaction	NOUN
ecletica-329	121	14	between	between	ADP
ecletica-329	121	15	this	this	DET
ecletica-329	121	16	ligand	ligand	NOUN
ecletica-329	121	17	and	and	CCONJ
ecletica-329	121	18	arg929	arg929	NOUN
ecletica-329	121	19	,	,	PUNCT
ecletica-329	121	20	resulting	result	VERB
ecletica-329	121	21	in	in	ADP
ecletica-329	121	22	the	the	DET
ecletica-329	121	23	stimulating	stimulating	ADJ
ecletica-329	121	24	effect	effect	NOUN
ecletica-329	121	25	upon	upon	SCONJ
ecletica-329	121	26	enzyme	enzyme	NOUN
ecletica-329	121	27	activity	activity	NOUN
ecletica-329	121	28	of	of	ADP
ecletica-329	121	29	this	this	DET
ecletica-329	121	30	drug	drug	NOUN
ecletica-329	121	31	.	.	PUNCT
ecletica-329	122	1	conclusion	conclusion	NOUN
ecletica-329	122	2	among	among	ADP
ecletica-329	122	3	the	the	DET
ecletica-329	122	4	tested	test	VERB
ecletica-329	122	5	compounds	compound	NOUN
ecletica-329	122	6	,	,	PUNCT
ecletica-329	122	7	piroxicam	piroxicam	PROPN
ecletica-329	122	8	is	be	AUX
ecletica-329	122	9	the	the	DET
ecletica-329	122	10	only	only	ADV
ecletica-329	122	11	useful	useful	ADJ
ecletica-329	122	12	as	as	ADP
ecletica-329	122	13	leader	leader	NOUN
ecletica-329	122	14	for	for	ADP
ecletica-329	122	15	the	the	DET
ecletica-329	122	16	synthesis	synthesis	NOUN
ecletica-329	122	17	of	of	ADP
ecletica-329	122	18	derivates	derivate	NOUN
ecletica-329	122	19	in	in	ADP
ecletica-329	122	20	the	the	DET
ecletica-329	122	21	search	search	NOUN
ecletica-329	122	22	of	of	ADP
ecletica-329	122	23	c.	c.	PROPN
ecletica-329	122	24	histolyticum	histolyticum	PROPN
ecletica-329	122	25	collagenase	collagenase	PROPN
ecletica-329	122	26	inhibitors	inhibitor	NOUN
ecletica-329	122	27	with	with	ADP
ecletica-329	122	28	larger	large	ADJ
ecletica-329	122	29	activity	activity	NOUN
ecletica-329	122	30	.	.	PUNCT
ecletica-329	123	1	eq06	eq06	PROPN
ecletica-329	123	2	-	-	PUNCT
ecletica-329	123	3	af	af	PROPN
ecletica-329	123	4	4/12/08	4/12/08	NUM
ecletica-329	123	5	9:55	9:55	NUM
ecletica-329	123	6	page	page	NOUN
ecletica-329	123	7	51	51	NUM
ecletica-329	123	8	references	reference	NOUN
ecletica-329	123	9	[	[	X
ecletica-329	123	10	1	1	NUM
ecletica-329	123	11	]	]	X
ecletica-329	123	12	i.	i.	PROPN
ecletica-329	123	13	mandl	mandl	PROPN
ecletica-329	123	14	,	,	PUNCT
ecletica-329	123	15	j.	j.	PROPN
ecletica-329	123	16	maclennan	maclennan	PROPN
ecletica-329	123	17	,	,	PUNCT
ecletica-329	123	18	e.	e.	PROPN
ecletica-329	123	19	howes	howes	PROPN
ecletica-329	123	20	,	,	PUNCT
ecletica-329	123	21	r.	r.	PROPN
ecletica-329	123	22	debellis	debellis	PROPN
ecletica-329	123	23	and	and	CCONJ
ecletica-329	123	24	a.	a.	NOUN
ecletica-329	123	25	sohler	sohler	NOUN
ecletica-329	123	26	,	,	PUNCT
ecletica-329	123	27	j	j	PROPN
ecletica-329	123	28	clin	clin	PROPN
ecletica-329	123	29	invest	invest	VERB
ecletica-329	123	30	32	32	NUM
ecletica-329	123	31	(	(	PUNCT
ecletica-329	123	32	1953	1953	NUM
ecletica-329	123	33	)	)	PUNCT
ecletica-329	123	34	1323	1323	NUM
ecletica-329	123	35	-	-	SYM
ecletica-329	123	36	1329	1329	NUM
ecletica-329	123	37	.	.	PUNCT
ecletica-329	124	1	[	[	X
ecletica-329	124	2	2	2	X
ecletica-329	124	3	]	]	PUNCT
ecletica-329	124	4	s.	s.	PROPN
ecletica-329	124	5	moore	moore	PROPN
ecletica-329	124	6	and	and	CCONJ
ecletica-329	124	7	w.	w.	PROPN
ecletica-329	124	8	h.	h.	PROPN
ecletica-329	124	9	stein	stein	PROPN
ecletica-329	124	10	,	,	PUNCT
ecletica-329	124	11	j	j	PROPN
ecletica-329	124	12	biol	biol	PROPN
ecletica-329	124	13	chem	chem	NOUN
ecletica-329	124	14	211	211	NUM
ecletica-329	124	15	(	(	PUNCT
ecletica-329	124	16	1954	1954	NUM
ecletica-329	124	17	)	)	PUNCT
ecletica-329	124	18	907	907	NUM
ecletica-329	124	19	-	-	SYM
ecletica-329	124	20	913	913	NUM
ecletica-329	124	21	.	.	PUNCT
ecletica-329	125	1	[	[	X
ecletica-329	125	2	3	3	NUM
ecletica-329	125	3	]	]	PUNCT
ecletica-329	125	4	a.barracchini	a.barracchini	NOUN
ecletica-329	125	5	,	,	PUNCT
ecletica-329	125	6	n.franceschini	n.franceschini	NOUN
ecletica-329	125	7	,	,	PUNCT
ecletica-329	125	8	g.minisola	g.minisola	NOUN
ecletica-329	125	9	,	,	PUNCT
ecletica-329	125	10	g.c.pantaleoni	g.c.pantaleoni	ADJ
ecletica-329	125	11	,	,	PUNCT
ecletica-329	125	12	a.di	a.di	PROPN
ecletica-329	125	13	giulio	giulio	NOUN
ecletica-329	125	14	,	,	PUNCT
ecletica-329	125	15	a.oratore	a.oratore	ADV
ecletica-329	125	16	,	,	PUNCT
ecletica-329	125	17	g.amicosante	g.amicosante	ADJ
ecletica-329	125	18	,	,	PUNCT
ecletica-329	125	19	1999	1999	NUM
ecletica-329	125	20	.	.	PUNCT
ecletica-329	126	1	meloxicam	meloxicam	NOUN
ecletica-329	126	2	and	and	CCONJ
ecletica-329	126	3	indometacin	indometacin	VERB
ecletica-329	126	4	activity	activity	NOUN
ecletica-329	126	5	on	on	ADP
ecletica-329	126	6	human	human	ADJ
ecletica-329	126	7	matrix	matrix	NOUN
ecletica-329	126	8	metalloproteinases	metalloproteinase	NOUN
ecletica-329	126	9	in	in	ADP
ecletica-329	126	10	synovial	synovial	ADJ
ecletica-329	126	11	fluid	fluid	NOUN
ecletica-329	126	12	.	.	PUNCT
ecletica-329	127	1	in	in	ADP
ecletica-329	127	2	:	:	PUNCT
ecletica-329	127	3	greenwald	greenwald	PROPN
ecletica-329	127	4	,	,	PUNCT
ecletica-329	127	5	r.a	r.a	PROPN
ecletica-329	127	6	.	.	PROPN
ecletica-329	127	7	,	,	PUNCT
ecletica-329	127	8	zucker	zucker	PROPN
ecletica-329	127	9	,	,	PUNCT
ecletica-329	127	10	s.	s.	PROPN
ecletica-329	127	11	,	,	PUNCT
ecletica-329	127	12	golub	golub	PROPN
ecletica-329	127	13	,	,	PUNCT
ecletica-329	127	14	l.m	l.m	PROPN
ecletica-329	127	15	.	.	PROPN
ecletica-329	127	16	(	(	PUNCT
ecletica-329	127	17	eds	ed	NOUN
ecletica-329	127	18	.	.	PUNCT
ecletica-329	127	19	)	)	PUNCT
ecletica-329	127	20	,	,	PUNCT
ecletica-329	127	21	inhibition	inhibition	NOUN
ecletica-329	127	22	of	of	ADP
ecletica-329	127	23	matrix	matrix	NOUN
ecletica-329	127	24	metalloproteinases	metalloproteinase	NOUN
ecletica-329	127	25	:	:	PUNCT
ecletica-329	127	26	therapeutic	therapeutic	ADJ
ecletica-329	127	27	applications	application	NOUN
ecletica-329	127	28	.	.	PUNCT
ecletica-329	128	1	new	new	PROPN
ecletica-329	128	2	york	york	PROPN
ecletica-329	128	3	academy	academy	PROPN
ecletica-329	128	4	of	of	ADP
ecletica-329	128	5	sciences	sciences	PROPN
ecletica-329	128	6	,	,	PUNCT
ecletica-329	128	7	new	new	PROPN
ecletica-329	128	8	york	york	PROPN
ecletica-329	128	9	,	,	PUNCT
ecletica-329	128	10	pp	pp	X
ecletica-329	128	11	.	.	PUNCT
ecletica-329	129	1	665	665	NUM
ecletica-329	129	2	-	-	SYM
ecletica-329	129	3	666	666	NUM
ecletica-329	129	4	.	.	PUNCT
ecletica-329	130	1	[	[	X
ecletica-329	130	2	4	4	NUM
ecletica-329	130	3	]	]	X
ecletica-329	130	4	l.	l.	PROPN
ecletica-329	130	5	m.	m.	PROPN
ecletica-329	130	6	golub	golub	PROPN
ecletica-329	130	7	,	,	PUNCT
ecletica-329	130	8	m.	m.	NOUN
ecletica-329	130	9	wolff	wolff	PROPN
ecletica-329	130	10	and	and	CCONJ
ecletica-329	130	11	h.	h.	PROPN
ecletica-329	130	12	m.	m.	PROPN
ecletica-329	130	13	lee	lee	PROPN
ecletica-329	130	14	,	,	PUNCT
ecletica-329	130	15	j.	j.	PROPN
ecletica-329	130	16	periodont	periodont	PROPN
ecletica-329	130	17	.	.	PUNCT
ecletica-329	131	1	res	re	NOUN
ecletica-329	131	2	.	.	PROPN
ecletica-329	132	1	20	20	NUM
ecletica-329	132	2	(	(	PUNCT
ecletica-329	132	3	1985	1985	NUM
ecletica-329	132	4	)	)	PUNCT
ecletica-329	132	5	12	12	NUM
ecletica-329	132	6	-	-	SYM
ecletica-329	132	7	23	23	NUM
ecletica-329	132	8	.	.	PUNCT
ecletica-329	133	1	[	[	X
ecletica-329	133	2	5	5	NUM
ecletica-329	133	3	]	]	PUNCT
ecletica-329	133	4	l.	l.	PROPN
ecletica-329	133	5	m.	m.	PROPN
ecletica-329	133	6	golub	golub	PROPN
ecletica-329	133	7	,	,	PUNCT
ecletica-329	133	8	s.	s.	PROPN
ecletica-329	133	9	ciancio	ciancio	PROPN
ecletica-329	133	10	,	,	PUNCT
ecletica-329	133	11	n.	n.	PROPN
ecletica-329	133	12	s.	s.	PROPN
ecletica-329	133	13	ramamurthy	ramamurthy	PROPN
ecletica-329	133	14	,	,	PUNCT
ecletica-329	133	15	m.	m.	NOUN
ecletica-329	133	16	leung	leung	PROPN
ecletica-329	133	17	and	and	CCONJ
ecletica-329	133	18	t.	t.	PROPN
ecletica-329	133	19	f.	f.	PROPN
ecletica-329	133	20	mcnamara	mcnamara	PROPN
ecletica-329	133	21	,	,	PUNCT
ecletica-329	133	22	j.	j.	PROPN
ecletica-329	133	23	periodont	periodont	PROPN
ecletica-329	133	24	.	.	PUNCT
ecletica-329	134	1	res	re	NOUN
ecletica-329	134	2	.	.	PROPN
ecletica-329	135	1	26	26	NUM
ecletica-329	135	2	(	(	PUNCT
ecletica-329	135	3	1990	1990	NUM
ecletica-329	135	4	)	)	PUNCT
ecletica-329	135	5	321	321	NUM
ecletica-329	135	6	-	-	SYM
ecletica-329	135	7	330	330	NUM
ecletica-329	135	8	.	.	PUNCT
ecletica-329	136	1	[	[	X
ecletica-329	136	2	6	6	NUM
ecletica-329	136	3	]	]	PUNCT
ecletica-329	136	4	l.	l.	PROPN
ecletica-329	136	5	m.	m.	PROPN
ecletica-329	136	6	golub	golub	PROPN
ecletica-329	136	7	,	,	PUNCT
ecletica-329	136	8	t.	t.	PROPN
ecletica-329	136	9	sorsa	sorsa	PROPN
ecletica-329	136	10	,	,	PUNCT
ecletica-329	136	11	h.	h.	PROPN
ecletica-329	136	12	m.	m.	PROPN
ecletica-329	136	13	lee	lee	PROPN
ecletica-329	136	14	,	,	PUNCT
ecletica-329	136	15	s.	s.	PROPN
ecletica-329	136	16	ciancio	ciancio	PROPN
ecletica-329	136	17	,	,	PUNCT
ecletica-329	136	18	d.	d.	PROPN
ecletica-329	136	19	sorbi	sorbi	PROPN
ecletica-329	136	20	,	,	PUNCT
ecletica-329	136	21	n.	n.	PROPN
ecletica-329	136	22	s.	s.	PROPN
ecletica-329	136	23	ramamurthy	ramamurthy	PROPN
ecletica-329	136	24	,	,	PUNCT
ecletica-329	136	25	b.	b.	PROPN
ecletica-329	136	26	gruber	gruber	PROPN
ecletica-329	136	27	,	,	PUNCT
ecletica-329	136	28	t.	t.	PROPN
ecletica-329	136	29	salo	salo	PROPN
ecletica-329	136	30	and	and	CCONJ
ecletica-329	136	31	y.	y.	PROPN
ecletica-329	136	32	t.	t.	PROPN
ecletica-329	136	33	konttinen	konttinen	PROPN
ecletica-329	136	34	,	,	PUNCT
ecletica-329	136	35	j.	j.	PROPN
ecletica-329	136	36	clin	clin	PROPN
ecletica-329	136	37	.	.	PUNCT
ecletica-329	137	1	periodont	periodont	PROPN
ecletica-329	137	2	.	.	PUNCT
ecletica-329	138	1	22	22	NUM
ecletica-329	138	2	(	(	PUNCT
ecletica-329	138	3	1995	1995	NUM
ecletica-329	138	4	)	)	PUNCT
ecletica-329	138	5	100	100	NUM
ecletica-329	138	6	-	-	SYM
ecletica-329	138	7	109	109	NUM
ecletica-329	138	8	.	.	PUNCT
ecletica-329	139	1	[	[	X
ecletica-329	139	2	7	7	NUM
ecletica-329	139	3	]	]	X
ecletica-329	139	4	l.m.golub	l.m.golub	NOUN
ecletica-329	139	5	,	,	PUNCT
ecletica-329	139	6	n.s.ramamurthy	n.s.ramamurthy	ADJ
ecletica-329	139	7	,	,	PUNCT
ecletica-329	139	8	a.llavaneras	a.llavaneras	ADJ
ecletica-329	139	9	,	,	PUNCT
ecletica-329	139	10	m.e.ryan	m.e.ryan	NOUN
ecletica-329	139	11	,	,	PUNCT
ecletica-329	139	12	h.m.lee	h.m.lee	PROPN
ecletica-329	139	13	,	,	PUNCT
ecletica-329	139	14	y.liu	y.liu	NOUN
ecletica-329	139	15	,	,	PUNCT
ecletica-329	139	16	s.bain	s.bain	NOUN
ecletica-329	139	17	,	,	PUNCT
ecletica-329	139	18	t.sorsa	t.sorsa	NOUN
ecletica-329	139	19	,	,	PUNCT
ecletica-329	139	20	1999	1999	NUM
ecletica-329	139	21	.	.	PUNCT
ecletica-329	140	1	a	a	DET
ecletica-329	140	2	chemically	chemically	ADV
ecletica-329	140	3	modified	modify	VERB
ecletica-329	140	4	nonantimicrobial	nonantimicrobial	ADJ
ecletica-329	140	5	tetracycline	tetracycline	NOUN
ecletica-329	140	6	(	(	PUNCT
ecletica-329	140	7	cmt-8	cmt-8	NOUN
ecletica-329	140	8	)	)	PUNCT
ecletica-329	140	9	inhibits	inhibit	VERB
ecletica-329	140	10	gingival	gingival	NOUN
ecletica-329	140	11	matrix	matrix	NOUN
ecletica-329	140	12	metalloproteinases	metalloproteinase	NOUN
ecletica-329	140	13	,	,	PUNCT
ecletica-329	140	14	periodontal	periodontal	ADJ
ecletica-329	140	15	breakdown	breakdown	NOUN
ecletica-329	140	16	,	,	PUNCT
ecletica-329	140	17	and	and	CCONJ
ecletica-329	140	18	extraoral	extraoral	ADJ
ecletica-329	140	19	bone	bone	NOUN
ecletica-329	140	20	loss	loss	NOUN
ecletica-329	140	21	in	in	ADP
ecletica-329	140	22	ovariectomized	ovariectomize	VERB
ecletica-329	140	23	rats	rat	NOUN
ecletica-329	140	24	.	.	PUNCT
ecletica-329	141	1	in	in	ADP
ecletica-329	141	2	:	:	PUNCT
ecletica-329	141	3	greenwald	greenwald	PROPN
ecletica-329	141	4	,	,	PUNCT
ecletica-329	141	5	r.a	r.a	PROPN
ecletica-329	141	6	.	.	PROPN
ecletica-329	141	7	,	,	PUNCT
ecletica-329	141	8	zucker	zucker	PROPN
ecletica-329	141	9	,	,	PUNCT
ecletica-329	141	10	s.	s.	PROPN
ecletica-329	141	11	,	,	PUNCT
ecletica-329	141	12	golub	golub	PROPN
ecletica-329	141	13	,	,	PUNCT
ecletica-329	141	14	l.m	l.m	PROPN
ecletica-329	141	15	.	.	PROPN
ecletica-329	141	16	(	(	PUNCT
ecletica-329	141	17	eds	ed	NOUN
ecletica-329	141	18	.	.	PUNCT
ecletica-329	141	19	)	)	PUNCT
ecletica-329	141	20	,	,	PUNCT
ecletica-329	141	21	inhibition	inhibition	NOUN
ecletica-329	141	22	of	of	ADP
ecletica-329	141	23	matrix	matrix	NOUN
ecletica-329	141	24	metalloproteinases	metalloproteinase	NOUN
ecletica-329	141	25	:	:	PUNCT
ecletica-329	141	26	therapeutic	therapeutic	ADJ
ecletica-329	141	27	applications	application	NOUN
ecletica-329	141	28	.	.	PUNCT
ecletica-329	142	1	new	new	PROPN
ecletica-329	142	2	york	york	PROPN
ecletica-329	142	3	academy	academy	PROPN
ecletica-329	142	4	of	of	ADP
ecletica-329	142	5	sciences	sciences	PROPN
ecletica-329	142	6	,	,	PUNCT
ecletica-329	142	7	new	new	PROPN
ecletica-329	142	8	york	york	PROPN
ecletica-329	142	9	,	,	PUNCT
ecletica-329	142	10	pp	pp	PROPN
ecletica-329	142	11	.	.	PUNCT
ecletica-329	143	1	290	290	NUM
ecletica-329	143	2	-	-	SYM
ecletica-329	143	3	310	310	NUM
ecletica-329	143	4	.	.	PUNCT
ecletica-329	144	1	[	[	X
ecletica-329	144	2	8	8	NUM
ecletica-329	144	3	]	]	X
ecletica-329	144	4	r.	r.	PROPN
ecletica-329	144	5	a.	a.	PROPN
ecletica-329	144	6	greenwald	greenwald	PROPN
ecletica-329	144	7	,	,	PUNCT
ecletica-329	144	8	l.	l.	PROPN
ecletica-329	144	9	m.	m.	PROPN
ecletica-329	144	10	golub	golub	PROPN
ecletica-329	144	11	,	,	PUNCT
ecletica-329	144	12	n.	n.	PROPN
ecletica-329	144	13	s.	s.	PROPN
ecletica-329	144	14	ramamurthy	ramamurthy	PROPN
ecletica-329	144	15	,	,	PUNCT
ecletica-329	144	16	m.	m.	NOUN
ecletica-329	144	17	chowdhury	chowdhury	PROPN
ecletica-329	144	18	,	,	PUNCT
ecletica-329	144	19	s.	s.	PROPN
ecletica-329	144	20	a.	a.	PROPN
ecletica-329	144	21	moak	moak	PROPN
ecletica-329	144	22	and	and	CCONJ
ecletica-329	144	23	t.	t.	PROPN
ecletica-329	144	24	sorsa	sorsa	PROPN
ecletica-329	144	25	,	,	PUNCT
ecletica-329	144	26	bone	bone	NOUN
ecletica-329	144	27	22	22	NUM
ecletica-329	144	28	(	(	PUNCT
ecletica-329	144	29	1998	1998	NUM
ecletica-329	144	30	)	)	PUNCT
ecletica-329	144	31	33	33	NUM
ecletica-329	144	32	-	-	SYM
ecletica-329	144	33	38	38	NUM
ecletica-329	144	34	.	.	PUNCT
ecletica-329	145	1	[	[	X
ecletica-329	145	2	9	9	NUM
ecletica-329	145	3	]	]	PUNCT
ecletica-329	145	4	o.teronen	o.teronen	NUM
ecletica-329	145	5	,	,	PUNCT
ecletica-329	145	6	p.heikkila	p.heikkila	ADJ
ecletica-329	145	7	,	,	PUNCT
ecletica-329	145	8	y.konttinen	y.konttinen	NOUN
ecletica-329	145	9	,	,	PUNCT
ecletica-329	145	10	m.laitinen	m.laitinen	NOUN
ecletica-329	145	11	,	,	PUNCT
ecletica-329	145	12	t.salo	t.salo	NOUN
ecletica-329	145	13	,	,	PUNCT
ecletica-329	145	14	r.hanemaaijer	r.hanemaaijer	NOUN
ecletica-329	145	15	,	,	PUNCT
ecletica-329	145	16	a.teronen	a.teronen	NOUN
ecletica-329	145	17	,	,	PUNCT
ecletica-329	145	18	t.sorsa	t.sorsa	NOUN
ecletica-329	145	19	,	,	PUNCT
ecletica-329	145	20	1999	1999	NUM
ecletica-329	145	21	.	.	PUNCT
ecletica-329	146	1	mmp	mmp	PROPN
ecletica-329	146	2	inhibition	inhibition	NOUN
ecletica-329	146	3	ad	ad	NOUN
ecletica-329	146	4	downregulation	downregulation	NOUN
ecletica-329	146	5	by	by	ADP
ecletica-329	146	6	biphosphonates	biphosphonate	NOUN
ecletica-329	146	7	.	.	PUNCT
ecletica-329	147	1	in	in	ADP
ecletica-329	147	2	:	:	PUNCT
ecletica-329	147	3	greenwald	greenwald	PROPN
ecletica-329	147	4	,	,	PUNCT
ecletica-329	147	5	r.a	r.a	PROPN
ecletica-329	147	6	.	.	PROPN
ecletica-329	147	7	,	,	PUNCT
ecletica-329	147	8	zucker	zucker	PROPN
ecletica-329	147	9	,	,	PUNCT
ecletica-329	147	10	s.	s.	PROPN
ecletica-329	147	11	,	,	PUNCT
ecletica-329	147	12	golub	golub	PROPN
ecletica-329	147	13	,	,	PUNCT
ecletica-329	147	14	l.m	l.m	PROPN
ecletica-329	147	15	.	.	PROPN
ecletica-329	147	16	(	(	PUNCT
ecletica-329	147	17	eds	ed	NOUN
ecletica-329	147	18	.	.	PUNCT
ecletica-329	147	19	)	)	PUNCT
ecletica-329	147	20	,	,	PUNCT
ecletica-329	147	21	inhibition	inhibition	NOUN
ecletica-329	147	22	of	of	ADP
ecletica-329	147	23	matrix	matrix	NOUN
ecletica-329	147	24	metalloproteinases	metalloproteinase	NOUN
ecletica-329	147	25	:	:	PUNCT
ecletica-329	147	26	therapeutic	therapeutic	ADJ
ecletica-329	147	27	applications	application	NOUN
ecletica-329	147	28	.	.	PUNCT
ecletica-329	148	1	new	new	PROPN
ecletica-329	148	2	york	york	PROPN
ecletica-329	148	3	academy	academy	PROPN
ecletica-329	148	4	of	of	ADP
ecletica-329	148	5	sciences	sciences	PROPN
ecletica-329	148	6	,	,	PUNCT
ecletica-329	148	7	new	new	PROPN
ecletica-329	148	8	york	york	PROPN
ecletica-329	148	9	,	,	PUNCT
ecletica-329	148	10	pp	pp	X
ecletica-329	148	11	.	.	PUNCT
ecletica-329	149	1	453	453	NUM
ecletica-329	149	2	-	-	SYM
ecletica-329	149	3	465	465	NUM
ecletica-329	149	4	.	.	PUNCT
ecletica-329	150	1	[	[	X
ecletica-329	150	2	10	10	NUM
ecletica-329	150	3	]	]	X
ecletica-329	150	4	i.	i.	NOUN
ecletica-329	150	5	schrödinger	schrödinger	NOUN
ecletica-329	150	6	,	,	PUNCT
ecletica-329	150	7	first	first	ADJ
ecletica-329	150	8	discovery	discovery	NOUN
ecletica-329	150	9	:	:	PUNCT
ecletica-329	150	10	technical	technical	ADJ
ecletica-329	150	11	notes	note	NOUN
ecletica-329	150	12	for	for	ADP
ecletica-329	150	13	version	version	NOUN
ecletica-329	150	14	1.8	1.8	NUM
ecletica-329	150	15	.	.	PUNCT
ecletica-329	151	1	schrödinger	schrödinger	PROPN
ecletica-329	151	2	,	,	PUNCT
ecletica-329	151	3	inc	inc	PROPN
ecletica-329	151	4	.	.	PROPN
ecletica-329	151	5	,	,	PUNCT
ecletica-329	151	6	portland	portland	PROPN
ecletica-329	151	7	,	,	PUNCT
ecletica-329	151	8	or	or	CCONJ
ecletica-329	151	9	,	,	PUNCT
ecletica-329	151	10	2001	2001	NUM
ecletica-329	151	11	.	.	PUNCT
ecletica-329	152	1	[	[	X
ecletica-329	152	2	11	11	NUM
ecletica-329	152	3	]	]	PUNCT
ecletica-329	152	4	i.	i.	NOUN
ecletica-329	152	5	schrödinger	schrödinger	PROPN
ecletica-329	152	6	,	,	PUNCT
ecletica-329	152	7	jaguar	jaguar	PROPN
ecletica-329	152	8	user	user	PROPN
ecletica-329	152	9	’s	’s	PART
ecletica-329	152	10	guide	guide	NOUN
ecletica-329	152	11	.	.	PUNCT
ecletica-329	153	1	version	version	NOUN
ecletica-329	153	2	4.1	4.1	NUM
ecletica-329	153	3	schrödinger	schrödinger	NOUN
ecletica-329	153	4	,	,	PUNCT
ecletica-329	153	5	inc	inc	PROPN
ecletica-329	153	6	.	.	PROPN
ecletica-329	153	7	,	,	PUNCT
ecletica-329	153	8	portland	portland	PROPN
ecletica-329	153	9	,	,	PUNCT
ecletica-329	153	10	or	or	CCONJ
ecletica-329	153	11	,	,	PUNCT
ecletica-329	153	12	2001	2001	NUM
ecletica-329	153	13	.	.	PUNCT
ecletica-329	154	1	[	[	X
ecletica-329	154	2	12	12	NUM
ecletica-329	154	3	]	]	PUNCT
ecletica-329	154	4	i.	i.	NOUN
ecletica-329	154	5	fujitsu	fujitsu	PROPN
ecletica-329	154	6	,	,	PUNCT
ecletica-329	154	7	cache	cache	PROPN
ecletica-329	154	8	5.0	5.0	NUM
ecletica-329	154	9	for	for	ADP
ecletica-329	154	10	windows	window	NOUN
ecletica-329	154	11	user	user	NOUN
ecletica-329	154	12	guide	guide	PROPN
ecletica-329	154	13	fujitsu	fujitsu	PROPN
ecletica-329	154	14	systems	systems	PROPN
ecletica-329	154	15	business	business	PROPN
ecletica-329	154	16	of	of	ADP
ecletica-329	154	17	america	america	PROPN
ecletica-329	154	18	,	,	PUNCT
ecletica-329	154	19	inc	inc	PROPN
ecletica-329	154	20	.	.	PROPN
ecletica-329	154	21	,	,	PUNCT
ecletica-329	154	22	2001	2001	NUM
ecletica-329	154	23	.	.	PUNCT
ecletica-329	155	1	[	[	X
ecletica-329	155	2	13	13	NUM
ecletica-329	155	3	]	]	PUNCT
ecletica-329	155	4	j.	j.	PROPN
ecletica-329	155	5	j.	j.	PROPN
ecletica-329	155	6	wilson	wilson	PROPN
ecletica-329	155	7	,	,	PUNCT
ecletica-329	155	8	o.	o.	PROPN
ecletica-329	155	9	matsushita	matsushita	PROPN
ecletica-329	155	10	,	,	PUNCT
ecletica-329	155	11	a.	a.	NOUN
ecletica-329	155	12	okabe	okabe	PROPN
ecletica-329	155	13	and	and	CCONJ
ecletica-329	155	14	j.	j.	PROPN
ecletica-329	155	15	sakon	sakon	PROPN
ecletica-329	155	16	,	,	PUNCT
ecletica-329	155	17	the	the	DET
ecletica-329	155	18	embo	embo	NOUN
ecletica-329	155	19	journal	journal	PROPN
ecletica-329	155	20	22	22	NUM
ecletica-329	155	21	(	(	PUNCT
ecletica-329	155	22	2003	2003	NUM
ecletica-329	155	23	)	)	PUNCT
ecletica-329	155	24	1743	1743	NUM
ecletica-329	155	25	-	-	SYM
ecletica-329	155	26	1752	1752	NUM
ecletica-329	155	27	.	.	PUNCT
ecletica-329	156	1	pay	pay	VERB
ecletica-329	156	2	attention	attention	NOUN
ecletica-329	156	3	that	that	SCONJ
ecletica-329	156	4	,	,	PUNCT
ecletica-329	156	5	the	the	DET
ecletica-329	156	6	calculations	calculation	NOUN
ecletica-329	156	7	for	for	ADP
ecletica-329	156	8	steric	steric	ADJ
ecletica-329	156	9	adjustment	adjustment	NOUN
ecletica-329	156	10	and	and	CCONJ
ecletica-329	156	11	bond	bond	NOUN
ecletica-329	156	12	formation	formation	NOUN
ecletica-329	156	13	between	between	ADP
ecletica-329	156	14	ligands	ligand	NOUN
ecletica-329	156	15	and	and	CCONJ
ecletica-329	156	16	enzyme	enzyme	VERB
ecletica-329	156	17	active	active	ADJ
ecletica-329	156	18	center	center	NOUN
ecletica-329	156	19	(	(	PUNCT
ecletica-329	156	20	“	"	PUNCT
ecletica-329	156	21	docking	docking	NOUN
ecletica-329	156	22	”	"	PUNCT
ecletica-329	156	23	)	)	PUNCT
ecletica-329	156	24	and	and	CCONJ
ecletica-329	156	25	to	to	PART
ecletica-329	156	26	obtain	obtain	VERB
ecletica-329	156	27	bond	bond	NOUN
ecletica-329	156	28	energies	energy	NOUN
ecletica-329	156	29	values	value	NOUN
ecletica-329	156	30	are	be	AUX
ecletica-329	156	31	very	very	ADV
ecletica-329	156	32	useful	useful	ADJ
ecletica-329	156	33	in	in	ADP
ecletica-329	156	34	the	the	DET
ecletica-329	156	35	interpretation	interpretation	NOUN
ecletica-329	156	36	of	of	ADP
ecletica-329	156	37	the	the	DET
ecletica-329	156	38	experimental	experimental	ADJ
ecletica-329	156	39	results	result	NOUN
ecletica-329	156	40	.	.	PUNCT
ecletica-329	157	1	but	but	CCONJ
ecletica-329	157	2	,	,	PUNCT
ecletica-329	157	3	as	as	ADP
ecletica-329	157	4	every	every	DET
ecletica-329	157	5	method	method	NOUN
ecletica-329	157	6	of	of	ADP
ecletica-329	157	7	computational	computational	ADJ
ecletica-329	157	8	simulation	simulation	NOUN
ecletica-329	157	9	,	,	PUNCT
ecletica-329	157	10	they	they	PRON
ecletica-329	157	11	have	have	VERB
ecletica-329	157	12	their	their	PRON
ecletica-329	157	13	limitations	limitation	NOUN
ecletica-329	157	14	and	and	CCONJ
ecletica-329	157	15	their	their	PRON
ecletica-329	157	16	results	result	NOUN
ecletica-329	157	17	should	should	AUX
ecletica-329	157	18	be	be	AUX
ecletica-329	157	19	considered	consider	VERB
ecletica-329	157	20	with	with	ADP
ecletica-329	157	21	caution	caution	NOUN
ecletica-329	157	22	.	.	PUNCT
ecletica-329	158	1	they	they	PRON
ecletica-329	158	2	must	must	AUX
ecletica-329	158	3	be	be	AUX
ecletica-329	158	4	considered	consider	VERB
ecletica-329	158	5	as	as	ADP
ecletica-329	158	6	an	an	DET
ecletica-329	158	7	aid	aid	NOUN
ecletica-329	158	8	for	for	ADP
ecletica-329	158	9	interpretation	interpretation	NOUN
ecletica-329	158	10	of	of	ADP
ecletica-329	158	11	the	the	DET
ecletica-329	158	12	experiences	experience	NOUN
ecletica-329	158	13	and	and	CCONJ
ecletica-329	158	14	for	for	ADP
ecletica-329	158	15	planning	plan	VERB
ecletica-329	158	16	news	news	NOUN
ecletica-329	158	17	ones	one	NOUN
ecletica-329	158	18	,	,	PUNCT
ecletica-329	158	19	but	but	CCONJ
ecletica-329	158	20	not	not	PART
ecletica-329	158	21	as	as	ADP
ecletica-329	158	22	their	their	PRON
ecletica-329	158	23	substitutes	substitute	NOUN
ecletica-329	158	24	.	.	PUNCT
ecletica-329	159	1	acknowledgements	acknowledgement	NOUN
ecletica-329	159	2	the	the	DET
ecletica-329	159	3	author	author	NOUN
ecletica-329	159	4	is	be	AUX
ecletica-329	159	5	grateful	grateful	ADJ
ecletica-329	159	6	to	to	PART
ecletica-329	159	7	fundação	fundação	VERB
ecletica-329	159	8	de	de	X
ecletica-329	159	9	amparo	amparo	PROPN
ecletica-329	159	10	à	à	X
ecletica-329	159	11	pesquisa	pesquisa	PROPN
ecletica-329	159	12	do	do	AUX
ecletica-329	159	13	estado	estado	PROPN
ecletica-329	159	14	de	de	PROPN
ecletica-329	159	15	são	são	PROPN
ecletica-329	159	16	paulo	paulo	PROPN
ecletica-329	159	17	(	(	PUNCT
ecletica-329	159	18	fapesp	fapesp	NOUN
ecletica-329	159	19	)	)	PUNCT
ecletica-329	159	20	for	for	ADP
ecletica-329	159	21	financial	financial	ADJ
ecletica-329	159	22	support	support	NOUN
ecletica-329	159	23	.	.	PUNCT
ecletica-329	160	1	received	receive	VERB
ecletica-329	160	2	may	may	AUX
ecletica-329	160	3	28	28	NUM
ecletica-329	160	4	2008	2008	NUM
ecletica-329	160	5	accepted	accept	VERB
ecletica-329	160	6	september	september	PROPN
ecletica-329	160	7	16	16	NUM
ecletica-329	160	8	2008	2008	NUM
ecletica-329	160	9	52	52	NUM
ecletica-329	160	10	ecl	ecl	PROPN
ecletica-329	160	11	.	.	PROPN
ecletica-329	160	12	quím	quím	PROPN
ecletica-329	160	13	.	.	PUNCT
ecletica-329	161	1	,	,	PUNCT
ecletica-329	161	2	são	são	PROPN
ecletica-329	161	3	paulo	paulo	PROPN
ecletica-329	161	4	,	,	PUNCT
ecletica-329	161	5	33(4	33(4	NUM
ecletica-329	161	6	):	):	PUNCT
ecletica-329	161	7	47	47	NUM
ecletica-329	161	8	-	-	SYM
ecletica-329	161	9	52	52	NUM
ecletica-329	161	10	,	,	PUNCT
ecletica-329	161	11	2008	2008	NUM
ecletica-329	161	12	s.	s.	PROPN
ecletica-329	161	13	r.	r.	PROPN
ecletica-329	161	14	a.	a.	PROPN
ecletica-329	161	15	leite	leite	PROPN
ecletica-329	161	16	.	.	PUNCT
ecletica-329	162	1	inibidores	inibidores	PROPN
ecletica-329	162	2	da	da	PROPN
ecletica-329	162	3	colagenase	colagenase	PROPN
ecletica-329	162	4	do	do	VERB
ecletica-329	162	5	clostridium	clostridium	NOUN
ecletica-329	162	6	histolyticum	histolyticum	NOUN
ecletica-329	162	7	resumo	resumo	NOUN
ecletica-329	162	8	:	:	PUNCT
ecletica-329	162	9	diferentes	diferentes	PROPN
ecletica-329	162	10	substâncias	substâncias	PROPN
ecletica-329	162	11	foram	foram	PROPN
ecletica-329	162	12	testadas	testadas	PROPN
ecletica-329	162	13	como	como	PROPN
ecletica-329	162	14	inibidores	inibidores	PROPN
ecletica-329	162	15	da	da	PROPN
ecletica-329	162	16	colagenase	colagenase	PROPN
ecletica-329	162	17	do	do	VERB
ecletica-329	162	18	clostridium	clostridium	NOUN
ecletica-329	162	19	histolyticum	histolyticum	NOUN
ecletica-329	162	20	,	,	PUNCT
ecletica-329	162	21	dos	do	VERB
ecletica-329	162	22	pontos	ponto	NOUN
ecletica-329	162	23	de	de	X
ecletica-329	162	24	vista	vista	X
ecletica-329	162	25	experimental	experimental	PROPN
ecletica-329	162	26	e	e	PROPN
ecletica-329	162	27	teórico	teórico	PROPN
ecletica-329	162	28	.	.	PUNCT
ecletica-329	163	1	a	a	DET
ecletica-329	163	2	atividade	atividade	PROPN
ecletica-329	163	3	da	da	PROPN
ecletica-329	163	4	colagenase	colagenase	PROPN
ecletica-329	163	5	,	,	PUNCT
ecletica-329	163	6	isolada	isolada	PROPN
ecletica-329	163	7	e	e	NOUN
ecletica-329	163	8	na	na	PROPN
ecletica-329	163	9	presença	presença	PROPN
ecletica-329	163	10	das	das	PROPN
ecletica-329	163	11	substâncias	substâncias	PROPN
ecletica-329	163	12	testadas	testada	NOUN
ecletica-329	163	13	,	,	PUNCT
ecletica-329	163	14	foi	foi	PROPN
ecletica-329	163	15	medida	medida	PROPN
ecletica-329	163	16	através	através	PROPN
ecletica-329	163	17	da	da	PROPN
ecletica-329	163	18	reação	reação	PROPN
ecletica-329	163	19	de	de	PROPN
ecletica-329	163	20	hidrólise	hidrólise	PROPN
ecletica-329	163	21	do	do	AUX
ecletica-329	163	22	colágeno	colágeno	VERB
ecletica-329	163	23	bovino	bovino	PROPN
ecletica-329	163	24	e	e	PROPN
ecletica-329	163	25	dosagem	dosagem	PROPN
ecletica-329	163	26	dos	do	VERB
ecletica-329	163	27	aminoácidos	aminoácido	NOUN
ecletica-329	163	28	liberados	liberado	NOUN
ecletica-329	163	29	.	.	PUNCT
ecletica-329	164	1	a	a	DET
ecletica-329	164	2	interação	interação	PROPN
ecletica-329	164	3	inibidor	inibidor	PROPN
ecletica-329	164	4	-	-	PUNCT
ecletica-329	164	5	enzima	enzima	PROPN
ecletica-329	164	6	foi	foi	PROPN
ecletica-329	164	7	estudada	estudada	PROPN
ecletica-329	164	8	teoricamente	teoricamente	PROPN
ecletica-329	164	9	,	,	PUNCT
ecletica-329	164	10	mediante	mediante	PROPN
ecletica-329	164	11	simulação	simulação	PROPN
ecletica-329	164	12	computacional	computacional	PROPN
ecletica-329	164	13	de	de	PROPN
ecletica-329	164	14	ancoragem	ancoragem	PROPN
ecletica-329	164	15	.	.	PUNCT
ecletica-329	165	1	das	das	PROPN
ecletica-329	165	2	substâncias	substâncias	PROPN
ecletica-329	165	3	testadas	testadas	PROPN
ecletica-329	165	4	,	,	PUNCT
ecletica-329	165	5	somente	somente	PROPN
ecletica-329	165	6	uma	uma	PROPN
ecletica-329	165	7	apresentou	apresentou	PROPN
ecletica-329	165	8	atividade	atividade	PROPN
ecletica-329	165	9	inibidora	inibidora	PROPN
ecletica-329	165	10	sobre	sobre	PROPN
ecletica-329	165	11	a	a	DET
ecletica-329	165	12	colagenase	colagenase	NOUN
ecletica-329	165	13	bacteriana	bacteriana	PROPN
ecletica-329	165	14	.	.	PUNCT
ecletica-329	166	1	palavras	palavra	NOUN
ecletica-329	166	2	-	-	PUNCT
ecletica-329	166	3	chave	chave	NOUN
ecletica-329	166	4	:	:	PUNCT
ecletica-329	166	5	clostridium	clostridium	NOUN
ecletica-329	166	6	histolyticum	histolyticum	NOUN
ecletica-329	166	7	,	,	PUNCT
ecletica-329	166	8	colagenase	colagenase	NOUN
ecletica-329	166	9	,	,	PUNCT
ecletica-329	166	10	inibidores	inibidore	NOUN
ecletica-329	166	11	,	,	PUNCT
ecletica-329	166	12	interação	interação	PROPN
ecletica-329	166	13	enzima	enzima	PROPN
ecletica-329	166	14	-	-	PUNCT
ecletica-329	166	15	ligante	ligante	NOUN
ecletica-329	166	16	.	.	PUNCT
ecletica-329	167	1	eq06	eq06	PROPN
ecletica-329	167	2	-	-	PUNCT
ecletica-329	167	3	af	af	PROPN
ecletica-329	167	4	4/12/08	4/12/08	NUM
ecletica-329	167	5	9:55	9:55	NUM
ecletica-329	167	6	page	page	NOUN
ecletica-329	167	7	52	52	NUM