id	sid	tid	token	lemma	pos
ecletica-510	1	1	a06v28n1.pdf	a06v28n1.pdf	VERB
ecletica-510	1	2	45	45	NUM
ecletica-510	1	3	structural	structural	ADJ
ecletica-510	1	4	bioinformatics	bioinformatics	NOUN
ecletica-510	1	5	study	study	NOUN
ecletica-510	1	6	of	of	ADP
ecletica-510	1	7	cyclin	cyclin	NOUN
ecletica-510	1	8	-	-	PUNCT
ecletica-510	1	9	dependent	dependent	ADJ
ecletica-510	1	10	kinases	kinase	NOUN
ecletica-510	1	11	complexed	complexe	VERB
ecletica-510	1	12	with	with	ADP
ecletica-510	1	13	inhibitors	inhibitor	NOUN
ecletica-510	1	14	f.	f.	NOUN
ecletica-510	1	15	canduri1	canduri1	PROPN
ecletica-510	1	16	;	;	PUNCT
ecletica-510	1	17	n.	n.	PROPN
ecletica-510	1	18	j.	j.	PROPN
ecletica-510	1	19	f.	f.	PROPN
ecletica-510	1	20	da	da	PROPN
ecletica-510	1	21	silveira1	silveira1	PROPN
ecletica-510	1	22	;	;	PUNCT
ecletica-510	1	23	j.	j.	PROPN
ecletica-510	1	24	c.	c.	PROPN
ecletica-510	1	25	camera	camera	PROPN
ecletica-510	1	26	jr1	jr1	PROPN
ecletica-510	1	27	;	;	PUNCT
ecletica-510	1	28	w.	w.	PROPN
ecletica-510	1	29	f.	f.	PROPN
ecletica-510	1	30	de	de	PROPN
ecletica-510	1	31	azevedo	azevedo	PROPN
ecletica-510	1	32	jr	jr	PROPN
ecletica-510	1	33	2	2	NUM
ecletica-510	1	34	1departamento	1departamento	NUM
ecletica-510	1	35	de	de	X
ecletica-510	1	36	física	física	PROPN
ecletica-510	1	37	ibilce	ibilce	PROPN
ecletica-510	1	38	,	,	PUNCT
ecletica-510	1	39	unesp	unesp	ADJ
ecletica-510	1	40	–	–	PUNCT
ecletica-510	1	41	cep	cep	ADV
ecletica-510	1	42	15054	15054	NUM
ecletica-510	1	43	-	-	SYM
ecletica-510	1	44	000	000	NUM
ecletica-510	1	45	–	–	PUNCT
ecletica-510	1	46	são	são	PROPN
ecletica-510	1	47	josé	josé	PROPN
ecletica-510	1	48	do	do	PROPN
ecletica-510	1	49	rio	rio	PROPN
ecletica-510	1	50	preto	preto	PROPN
ecletica-510	1	51	spbrasil	spbrasil	NOUN
ecletica-510	1	52	.	.	PUNCT
ecletica-510	2	1	2center	2center	NUM
ecletica-510	2	2	for	for	ADP
ecletica-510	2	3	applied	applied	ADJ
ecletica-510	2	4	toxinology	toxinology	NOUN
ecletica-510	2	5	.instituto	.instituto	X
ecletica-510	2	6	butantan	butantan	PROPN
ecletica-510	2	7	–	–	PUNCT
ecletica-510	2	8	cep	cep	NOUN
ecletica-510	2	9	05503	05503	NUM
ecletica-510	2	10	-	-	SYM
ecletica-510	2	11	900	900	NUM
ecletica-510	2	12	são	são	NOUN
ecletica-510	2	13	paulo	paulo	NOUN
ecletica-510	2	14	–	–	PUNCT
ecletica-510	2	15	sp	sp	ADP
ecletica-510	2	16	-	-	PUNCT
ecletica-510	2	17	.	.	PUNCT
ecletica-510	2	18	brasil	brasil	PROPN
ecletica-510	2	19	.	.	PUNCT
ecletica-510	3	1	introduction	introduction	NOUN
ecletica-510	3	2	cell	cell	NOUN
ecletica-510	3	3	cycle	cycle	NOUN
ecletica-510	3	4	progression	progression	NOUN
ecletica-510	3	5	is	be	AUX
ecletica-510	3	6	tightly	tightly	ADV
ecletica-510	3	7	controlled	control	VERB
ecletica-510	3	8	by	by	ADP
ecletica-510	3	9	the	the	DET
ecletica-510	3	10	activity	activity	NOUN
ecletica-510	3	11	of	of	ADP
ecletica-510	3	12	cyclin	cyclin	NOUN
ecletica-510	3	13	-	-	PUNCT
ecletica-510	3	14	dependent	dependent	ADJ
ecletica-510	3	15	kinases	kinase	NOUN
ecletica-510	3	16	(	(	PUNCT
ecletica-510	3	17	cdks	cdks	NOUN
ecletica-510	3	18	)	)	PUNCT
ecletica-510	4	1	[	[	X
ecletica-510	4	2	31	31	NUM
ecletica-510	4	3	]	]	PUNCT
ecletica-510	4	4	.	.	PUNCT
ecletica-510	5	1	cdks	cdks	PROPN
ecletica-510	5	2	are	be	AUX
ecletica-510	5	3	inactive	inactive	ADJ
ecletica-510	5	4	as	as	ADP
ecletica-510	5	5	monomers	monomer	NOUN
ecletica-510	5	6	,	,	PUNCT
ecletica-510	5	7	and	and	CCONJ
ecletica-510	5	8	activation	activation	NOUN
ecletica-510	5	9	requires	require	VERB
ecletica-510	5	10	binding	bind	VERB
ecletica-510	5	11	to	to	ADP
ecletica-510	5	12	cyclins	cyclin	NOUN
ecletica-510	5	13	,	,	PUNCT
ecletica-510	5	14	a	a	DET
ecletica-510	5	15	diverse	diverse	ADJ
ecletica-510	5	16	family	family	NOUN
ecletica-510	5	17	of	of	ADP
ecletica-510	5	18	proteins	protein	NOUN
ecletica-510	5	19	whose	whose	DET
ecletica-510	5	20	levels	level	NOUN
ecletica-510	5	21	oscillate	oscillate	VERB
ecletica-510	5	22	during	during	ADP
ecletica-510	5	23	the	the	DET
ecletica-510	5	24	cell	cell	NOUN
ecletica-510	5	25	cycle	cycle	NOUN
ecletica-510	5	26	,	,	PUNCT
ecletica-510	5	27	and	and	CCONJ
ecletica-510	5	28	phosphorylation	phosphorylation	NOUN
ecletica-510	5	29	by	by	ADP
ecletica-510	5	30	cdk	cdk	PROPN
ecletica-510	5	31	-	-	PUNCT
ecletica-510	5	32	activating	activate	VERB
ecletica-510	5	33	kinase	kinase	NOUN
ecletica-510	5	34	(	(	PUNCT
ecletica-510	5	35	cak	cak	PROPN
ecletica-510	5	36	)	)	PUNCT
ecletica-510	5	37	on	on	ADP
ecletica-510	5	38	a	a	DET
ecletica-510	5	39	specific	specific	ADJ
ecletica-510	5	40	threonine	threonine	ADJ
ecletica-510	5	41	residue	residue	NOUN
ecletica-510	5	42	[	[	X
ecletica-510	5	43	19	19	NUM
ecletica-510	5	44	]	]	PUNCT
ecletica-510	5	45	.	.	PUNCT
ecletica-510	6	1	in	in	ADP
ecletica-510	6	2	addition	addition	NOUN
ecletica-510	6	3	to	to	ADP
ecletica-510	6	4	the	the	DET
ecletica-510	6	5	positive	positive	ADJ
ecletica-510	6	6	regulatory	regulatory	ADJ
ecletica-510	6	7	role	role	NOUN
ecletica-510	6	8	of	of	ADP
ecletica-510	6	9	cyclins	cyclin	NOUN
ecletica-510	6	10	and	and	CCONJ
ecletica-510	6	11	cak	cak	NOUN
ecletica-510	6	12	,	,	PUNCT
ecletica-510	6	13	many	many	ADJ
ecletica-510	6	14	negative	negative	ADJ
ecletica-510	6	15	regulatory	regulatory	ADJ
ecletica-510	6	16	proteins	protein	NOUN
ecletica-510	6	17	(	(	PUNCT
ecletica-510	6	18	cdk	cdk	NOUN
ecletica-510	6	19	inhibitors	inhibitor	NOUN
ecletica-510	6	20	,	,	PUNCT
ecletica-510	6	21	ckis	cki	NOUN
ecletica-510	6	22	)	)	PUNCT
ecletica-510	6	23	have	have	AUX
ecletica-510	6	24	been	be	AUX
ecletica-510	6	25	discovered	discover	VERB
ecletica-510	6	26	[	[	PUNCT
ecletica-510	6	27	34	34	NUM
ecletica-510	6	28	]	]	PUNCT
ecletica-510	6	29	.	.	PUNCT
ecletica-510	7	1	since	since	SCONJ
ecletica-510	7	2	deregulation	deregulation	NOUN
ecletica-510	7	3	of	of	ADP
ecletica-510	7	4	cyclins	cyclin	NOUN
ecletica-510	7	5	and/or	and/or	CCONJ
ecletica-510	7	6	alteration	alteration	NOUN
ecletica-510	7	7	or	or	CCONJ
ecletica-510	7	8	absence	absence	NOUN
ecletica-510	7	9	of	of	ADP
ecletica-510	7	10	ckis	cki	NOUN
ecletica-510	7	11	have	have	AUX
ecletica-510	7	12	been	be	AUX
ecletica-510	7	13	associated	associate	VERB
ecletica-510	7	14	with	with	ADP
ecletica-510	7	15	many	many	ADJ
ecletica-510	7	16	cancers	cancer	NOUN
ecletica-510	7	17	,	,	PUNCT
ecletica-510	7	18	there	there	PRON
ecletica-510	7	19	is	be	VERB
ecletica-510	7	20	strong	strong	ADJ
ecletica-510	7	21	interest	interest	NOUN
ecletica-510	7	22	in	in	ADP
ecletica-510	7	23	cdks	cdks	ADJ
ecletica-510	7	24	inhibitors	inhibitor	NOUN
ecletica-510	7	25	that	that	PRON
ecletica-510	7	26	could	could	AUX
ecletica-510	7	27	play	play	VERB
ecletica-510	7	28	an	an	DET
ecletica-510	7	29	important	important	ADJ
ecletica-510	7	30	role	role	NOUN
ecletica-510	7	31	in	in	ADP
ecletica-510	7	32	the	the	DET
ecletica-510	7	33	discovery	discovery	NOUN
ecletica-510	7	34	of	of	ADP
ecletica-510	7	35	a	a	DET
ecletica-510	7	36	new	new	ADJ
ecletica-510	7	37	family	family	NOUN
ecletica-510	7	38	of	of	ADP
ecletica-510	7	39	antitumor	antitumor	PROPN
ecletica-510	7	40	agents	agent	NOUN
ecletica-510	7	41	[	[	X
ecletica-510	7	42	17	17	NUM
ecletica-510	7	43	]	]	PUNCT
ecletica-510	7	44	.	.	PUNCT
ecletica-510	8	1	cdks	cdks	PROPN
ecletica-510	8	2	also	also	ADV
ecletica-510	8	3	play	play	VERB
ecletica-510	8	4	a	a	DET
ecletica-510	8	5	role	role	NOUN
ecletica-510	8	6	in	in	ADP
ecletica-510	8	7	apoptosis	apoptosis	NOUN
ecletica-510	8	8	(	(	PUNCT
ecletica-510	8	9	cdk2	cdk2	PROPN
ecletica-510	8	10	)	)	PUNCT
ecletica-510	8	11	,	,	PUNCT
ecletica-510	8	12	in	in	ADP
ecletica-510	8	13	neuronal	neuronal	ADJ
ecletica-510	8	14	cells	cell	NOUN
ecletica-510	8	15	(	(	PUNCT
ecletica-510	8	16	cdk5	cdk5	PROPN
ecletica-510	8	17	)	)	PUNCT
ecletica-510	8	18	and	and	CCONJ
ecletica-510	8	19	in	in	ADP
ecletica-510	8	20	the	the	DET
ecletica-510	8	21	control	control	NOUN
ecletica-510	8	22	of	of	ADP
ecletica-510	8	23	transcription	transcription	NOUN
ecletica-510	8	24	(	(	PUNCT
ecletica-510	8	25	cdk7	cdk7	NOUN
ecletica-510	8	26	,	,	PUNCT
ecletica-510	8	27	8	8	NUM
ecletica-510	8	28	,	,	PUNCT
ecletica-510	8	29	9	9	NUM
ecletica-510	8	30	)	)	PUNCT
ecletica-510	9	1	[	[	X
ecletica-510	9	2	9,20	9,20	X
ecletica-510	9	3	]	]	PUNCT
ecletica-510	9	4	.	.	PUNCT
ecletica-510	10	1	cdk5	cdk5	PROPN
ecletica-510	10	2	is	be	AUX
ecletica-510	10	3	unique	unique	ADJ
ecletica-510	10	4	in	in	ADP
ecletica-510	10	5	the	the	DET
ecletica-510	10	6	sense	sense	NOUN
ecletica-510	10	7	that	that	SCONJ
ecletica-510	10	8	although	although	SCONJ
ecletica-510	10	9	it	it	PRON
ecletica-510	10	10	is	be	AUX
ecletica-510	10	11	widely	widely	ADV
ecletica-510	10	12	expressed	express	VERB
ecletica-510	10	13	in	in	ADP
ecletica-510	10	14	many	many	ADJ
ecletica-510	10	15	tissues	tissue	NOUN
ecletica-510	10	16	and	and	CCONJ
ecletica-510	10	17	cells	cell	NOUN
ecletica-510	10	18	,	,	PUNCT
ecletica-510	10	19	the	the	DET
ecletica-510	10	20	cdk5	cdk5	PROPN
ecletica-510	10	21	kinase	kinase	PROPN
ecletica-510	10	22	activity	activity	NOUN
ecletica-510	10	23	is	be	AUX
ecletica-510	10	24	restricted	restrict	VERB
ecletica-510	10	25	to	to	ADP
ecletica-510	10	26	neuronal	neuronal	ADJ
ecletica-510	10	27	cells	cell	NOUN
ecletica-510	10	28	[	[	X
ecletica-510	10	29	10	10	NUM
ecletica-510	10	30	]	]	PUNCT
ecletica-510	10	31	.	.	PUNCT
ecletica-510	11	1	this	this	DET
ecletica-510	11	2	specificity	specificity	NOUN
ecletica-510	11	3	for	for	ADP
ecletica-510	11	4	neuronal	neuronal	ADJ
ecletica-510	11	5	tissue	tissue	NOUN
ecletica-510	11	6	is	be	AUX
ecletica-510	11	7	the	the	DET
ecletica-510	11	8	result	result	NOUN
ecletica-510	11	9	of	of	ADP
ecletica-510	11	10	the	the	DET
ecletica-510	11	11	cdk5	cdk5	NOUN
ecletica-510	11	12	activator	activator	NOUN
ecletica-510	11	13	proteins	protein	NOUN
ecletica-510	11	14	p35	p35	NOUN
ecletica-510	11	15	,	,	PUNCT
ecletica-510	11	16	p25	p25	NOUN
ecletica-510	11	17	,	,	PUNCT
ecletica-510	11	18	and	and	CCONJ
ecletica-510	11	19	p39	p39	ADV
ecletica-510	11	20	.	.	PUNCT
ecletica-510	12	1	cdk5	cdk5	PROPN
ecletica-510	12	2	is	be	AUX
ecletica-510	12	3	a	a	DET
ecletica-510	12	4	multifunctional	multifunctional	ADJ
ecletica-510	12	5	kinase	kinase	NOUN
ecletica-510	12	6	that	that	PRON
ecletica-510	12	7	associates	associate	NOUN
ecletica-510	12	8	with	with	ADP
ecletica-510	12	9	other	other	ADJ
ecletica-510	12	10	cell	cell	NOUN
ecletica-510	12	11	proteins	protein	NOUN
ecletica-510	12	12	to	to	PART
ecletica-510	12	13	interact	interact	VERB
ecletica-510	12	14	with	with	ADP
ecletica-510	12	15	the	the	DET
ecletica-510	12	16	cytoskeleton	cytoskeleton	NOUN
ecletica-510	12	17	and	and	CCONJ
ecletica-510	12	18	form	form	VERB
ecletica-510	12	19	supramolecular	supramolecular	ADJ
ecletica-510	12	20	complexes	complex	NOUN
ecletica-510	12	21	.	.	PUNCT
ecletica-510	13	1	recent	recent	ADJ
ecletica-510	13	2	investigations	investigation	NOUN
ecletica-510	13	3	have	have	AUX
ecletica-510	13	4	revealed	reveal	VERB
ecletica-510	13	5	that	that	SCONJ
ecletica-510	13	6	most	most	ADJ
ecletica-510	13	7	of	of	ADP
ecletica-510	13	8	the	the	DET
ecletica-510	13	9	cdk5	cdk5	NOUN
ecletica-510	13	10	in	in	ADP
ecletica-510	13	11	cells	cell	NOUN
ecletica-510	13	12	forms	form	VERB
ecletica-510	13	13	large	large	ADJ
ecletica-510	13	14	multimeric	multimeric	ADJ
ecletica-510	13	15	complexes	complex	NOUN
ecletica-510	13	16	of	of	ADP
ecletica-510	13	17	high	high	ADJ
ecletica-510	13	18	molecular	molecular	ADJ
ecletica-510	13	19	weight	weight	NOUN
ecletica-510	13	20	,	,	PUNCT
ecletica-510	13	21	ranging	range	VERB
ecletica-510	13	22	from	from	ADP
ecletica-510	13	23	60	60	NUM
ecletica-510	13	24	to	to	PART
ecletica-510	13	25	670	670	NUM
ecletica-510	13	26	kda	kda	NOUN
ecletica-510	13	27	,	,	PUNCT
ecletica-510	13	28	in	in	ADP
ecletica-510	13	29	which	which	PRON
ecletica-510	13	30	it	it	PRON
ecletica-510	13	31	is	be	AUX
ecletica-510	13	32	associated	associate	VERB
ecletica-510	13	33	with	with	ADP
ecletica-510	13	34	p25	p25	PROPN
ecletica-510	13	35	,	,	PUNCT
ecletica-510	13	36	p35	p35	NOUN
ecletica-510	13	37	,	,	PUNCT
ecletica-510	13	38	abstract	abstract	ADV
ecletica-510	13	39	the	the	DET
ecletica-510	13	40	present	present	ADJ
ecletica-510	13	41	work	work	NOUN
ecletica-510	13	42	describes	describe	VERB
ecletica-510	13	43	molecular	molecular	ADJ
ecletica-510	13	44	models	model	NOUN
ecletica-510	13	45	for	for	ADP
ecletica-510	13	46	the	the	DET
ecletica-510	13	47	binary	binary	ADJ
ecletica-510	13	48	complexes	complex	NOUN
ecletica-510	13	49	cdk9	cdk9	PROPN
ecletica-510	13	50	,	,	PUNCT
ecletica-510	13	51	cdk5	cdk5	PROPN
ecletica-510	13	52	and	and	CCONJ
ecletica-510	13	53	cdk1	cdk1	PROPN
ecletica-510	13	54	complexed	complexe	VERB
ecletica-510	13	55	with	with	ADP
ecletica-510	13	56	flavopiridol	flavopiridol	NOUN
ecletica-510	13	57	and	and	CCONJ
ecletica-510	13	58	roscovitine	roscovitine	NOUN
ecletica-510	13	59	.	.	PUNCT
ecletica-510	14	1	these	these	DET
ecletica-510	14	2	structural	structural	ADJ
ecletica-510	14	3	models	model	NOUN
ecletica-510	14	4	indicate	indicate	VERB
ecletica-510	14	5	that	that	SCONJ
ecletica-510	14	6	the	the	DET
ecletica-510	14	7	inhibitors	inhibitor	NOUN
ecletica-510	14	8	strongly	strongly	ADV
ecletica-510	14	9	bind	bind	VERB
ecletica-510	14	10	to	to	ADP
ecletica-510	14	11	the	the	DET
ecletica-510	14	12	atp	atp	NOUN
ecletica-510	14	13	-	-	PUNCT
ecletica-510	14	14	binding	bind	VERB
ecletica-510	14	15	pocket	pocket	NOUN
ecletica-510	14	16	of	of	ADP
ecletica-510	14	17	cdks	cdks	NOUN
ecletica-510	14	18	and	and	CCONJ
ecletica-510	14	19	the	the	DET
ecletica-510	14	20	structural	structural	ADJ
ecletica-510	14	21	comparison	comparison	NOUN
ecletica-510	14	22	with	with	ADP
ecletica-510	14	23	the	the	DET
ecletica-510	14	24	complexes	complex	NOUN
ecletica-510	14	25	cdk2	cdk2	PROPN
ecletica-510	14	26	:	:	PUNCT
ecletica-510	14	27	flavopiridol	flavopiridol	PROPN
ecletica-510	14	28	and	and	CCONJ
ecletica-510	14	29	cdk2	cdk2	PROPN
ecletica-510	14	30	:	:	PUNCT
ecletica-510	14	31	roscovitine	roscovitine	PROPN
ecletica-510	14	32	correlates	correlate	VERB
ecletica-510	14	33	the	the	DET
ecletica-510	14	34	structural	structural	ADJ
ecletica-510	14	35	differences	difference	NOUN
ecletica-510	14	36	with	with	ADP
ecletica-510	14	37	differences	difference	NOUN
ecletica-510	14	38	in	in	ADP
ecletica-510	14	39	inhibition	inhibition	NOUN
ecletica-510	14	40	of	of	ADP
ecletica-510	14	41	these	these	DET
ecletica-510	14	42	cdks	cdks	NOUN
ecletica-510	14	43	by	by	ADP
ecletica-510	14	44	the	the	DET
ecletica-510	14	45	inhibitors	inhibitor	NOUN
ecletica-510	14	46	.	.	PUNCT
ecletica-510	15	1	these	these	DET
ecletica-510	15	2	structures	structure	NOUN
ecletica-510	15	3	open	open	VERB
ecletica-510	15	4	the	the	DET
ecletica-510	15	5	possibility	possibility	NOUN
ecletica-510	15	6	of	of	ADP
ecletica-510	15	7	testing	test	VERB
ecletica-510	15	8	new	new	ADJ
ecletica-510	15	9	inhibitor	inhibitor	NOUN
ecletica-510	15	10	families	family	NOUN
ecletica-510	15	11	,	,	PUNCT
ecletica-510	15	12	in	in	ADP
ecletica-510	15	13	addition	addition	NOUN
ecletica-510	15	14	to	to	ADP
ecletica-510	15	15	new	new	ADJ
ecletica-510	15	16	substituents	substituent	NOUN
ecletica-510	15	17	for	for	ADP
ecletica-510	15	18	the	the	DET
ecletica-510	15	19	already	already	ADV
ecletica-510	15	20	known	know	VERB
ecletica-510	15	21	lead	lead	NOUN
ecletica-510	15	22	structures	structure	NOUN
ecletica-510	15	23	such	such	ADJ
ecletica-510	15	24	as	as	ADP
ecletica-510	15	25	flavones	flavone	NOUN
ecletica-510	15	26	and	and	CCONJ
ecletica-510	15	27	adenine	adenine	VERB
ecletica-510	15	28	derivatives	derivative	NOUN
ecletica-510	15	29	.	.	PUNCT
ecletica-510	16	1	keywords	keyword	NOUN
ecletica-510	16	2	:	:	PUNCT
ecletica-510	16	3	cdk	cdk	NOUN
ecletica-510	16	4	,	,	PUNCT
ecletica-510	16	5	flavopiridol	flavopiridol	NOUN
ecletica-510	16	6	,	,	PUNCT
ecletica-510	16	7	bioinformatics	bioinformatics	NOUN
ecletica-510	16	8	,	,	PUNCT
ecletica-510	16	9	structure	structure	NOUN
ecletica-510	16	10	,	,	PUNCT
ecletica-510	16	11	drug	drug	NOUN
ecletica-510	16	12	design	design	NOUN
ecletica-510	16	13	.	.	PUNCT
ecletica-510	17	1	volume	volume	NOUN
ecletica-510	17	2	28	28	NUM
ecletica-510	17	3	(	(	PUNCT
ecletica-510	17	4	2003	2003	NUM
ecletica-510	17	5	)	)	PUNCT
ecletica-510	17	6	número	número	NOUN
ecletica-510	17	7	1	1	NUM
ecletica-510	17	8	www.scielo.br/eq	www.scielo.br/eq	PROPN
ecletica-510	17	9	ecl	ecl	PROPN
ecletica-510	17	10	.	.	PROPN
ecletica-510	17	11	quím	quím	PROPN
ecletica-510	17	12	.	.	PUNCT
ecletica-510	18	1	,	,	PUNCT
ecletica-510	18	2	são	são	PROPN
ecletica-510	18	3	paulo	paulo	PROPN
ecletica-510	18	4	,	,	PUNCT
ecletica-510	18	5	28(1	28(1	NOUN
ecletica-510	18	6	):	):	PUNCT
ecletica-510	18	7	45	45	NUM
ecletica-510	18	8	-	-	SYM
ecletica-510	18	9	53	53	NUM
ecletica-510	18	10	,	,	PUNCT
ecletica-510	18	11	2003	2003	NUM
ecletica-510	18	12	46	46	NUM
ecletica-510	18	13	synapsin	synapsin	NOUN
ecletica-510	18	14	,	,	PUNCT
ecletica-510	18	15	tau	tau	PROPN
ecletica-510	18	16	,	,	PUNCT
ecletica-510	18	17	b	b	X
ecletica-510	18	18	-	-	PUNCT
ecletica-510	18	19	catenins	catenin	NOUN
ecletica-510	18	20	,	,	PUNCT
ecletica-510	18	21	and	and	CCONJ
ecletica-510	18	22	n	n	CCONJ
ecletica-510	18	23	-	-	PUNCT
ecletica-510	18	24	cadherins	cadherin	VERB
ecletica-510	18	25	[	[	X
ecletica-510	18	26	33	33	NUM
ecletica-510	18	27	]	]	PUNCT
ecletica-510	18	28	.	.	PUNCT
ecletica-510	19	1	increased	increase	VERB
ecletica-510	19	2	cdk5	cdk5	PROPN
ecletica-510	19	3	kinase	kinase	PROPN
ecletica-510	19	4	activity	activity	NOUN
ecletica-510	19	5	has	have	AUX
ecletica-510	19	6	been	be	AUX
ecletica-510	19	7	implicated	implicate	VERB
ecletica-510	19	8	in	in	ADP
ecletica-510	19	9	alzheimer´s	alzheimer´s	NOUN
ecletica-510	19	10	disease	disease	NOUN
ecletica-510	19	11	.	.	PUNCT
ecletica-510	20	1	furthermore	furthermore	ADV
ecletica-510	20	2	,	,	PUNCT
ecletica-510	20	3	pretreatment	pretreatment	NOUN
ecletica-510	20	4	of	of	ADP
ecletica-510	20	5	cells	cell	NOUN
ecletica-510	20	6	with	with	ADP
ecletica-510	20	7	cdk5	cdk5	NOUN
ecletica-510	20	8	inhibitors	inhibitor	NOUN
ecletica-510	20	9	protected	protect	VERB
ecletica-510	20	10	them	they	PRON
ecletica-510	20	11	against	against	ADP
ecletica-510	20	12	neuronal	neuronal	ADJ
ecletica-510	20	13	death	death	NOUN
ecletica-510	21	1	[	[	X
ecletica-510	21	2	1	1	NUM
ecletica-510	21	3	]	]	PUNCT
ecletica-510	21	4	.	.	PUNCT
ecletica-510	22	1	since	since	SCONJ
ecletica-510	22	2	deregulation	deregulation	NOUN
ecletica-510	22	3	of	of	ADP
ecletica-510	22	4	cdk5	cdk5	PROPN
ecletica-510	22	5	has	have	AUX
ecletica-510	22	6	been	be	AUX
ecletica-510	22	7	implicated	implicate	VERB
ecletica-510	22	8	in	in	ADP
ecletica-510	22	9	alzheimer´s	alzheimer´s	NOUN
ecletica-510	22	10	disease	disease	NOUN
ecletica-510	22	11	,	,	PUNCT
ecletica-510	22	12	there	there	PRON
ecletica-510	22	13	is	be	VERB
ecletica-510	22	14	strong	strong	ADJ
ecletica-510	22	15	interest	interest	NOUN
ecletica-510	22	16	in	in	ADP
ecletica-510	22	17	cdk5	cdk5	NOUN
ecletica-510	22	18	inhibitors	inhibitor	NOUN
ecletica-510	22	19	that	that	PRON
ecletica-510	22	20	could	could	AUX
ecletica-510	22	21	play	play	VERB
ecletica-510	22	22	an	an	DET
ecletica-510	22	23	important	important	ADJ
ecletica-510	22	24	role	role	NOUN
ecletica-510	22	25	in	in	ADP
ecletica-510	22	26	the	the	DET
ecletica-510	22	27	discovery	discovery	NOUN
ecletica-510	22	28	of	of	ADP
ecletica-510	22	29	antialzheimer´s	antialzheimer´s	NOUN
ecletica-510	22	30	disease	disease	NOUN
ecletica-510	22	31	agents	agent	NOUN
ecletica-510	22	32	.	.	PUNCT
ecletica-510	23	1	flavopiridol	flavopiridol	VERB
ecletica-510	23	2	a	a	DET
ecletica-510	23	3	cyclin	cyclin	NOUN
ecletica-510	23	4	-	-	PUNCT
ecletica-510	23	5	dependent	dependent	ADJ
ecletica-510	23	6	kinase	kinase	NOUN
ecletica-510	23	7	(	(	PUNCT
ecletica-510	23	8	cdk	cdk	PROPN
ecletica-510	23	9	)	)	PUNCT
ecletica-510	23	10	inhibitor	inhibitor	NOUN
ecletica-510	23	11	is	be	AUX
ecletica-510	23	12	a	a	DET
ecletica-510	23	13	potential	potential	ADJ
ecletica-510	23	14	anti	anti	ADJ
ecletica-510	23	15	-	-	ADJ
ecletica-510	23	16	cancer	cancer	ADJ
ecletica-510	23	17	therapeutic	therapeutic	ADJ
ecletica-510	23	18	agent	agent	NOUN
ecletica-510	23	19	currently	currently	ADV
ecletica-510	23	20	being	be	AUX
ecletica-510	23	21	tested	test	VERB
ecletica-510	23	22	in	in	ADP
ecletica-510	23	23	phase	phase	NOUN
ecletica-510	23	24	i	i	PRON
ecletica-510	23	25	and	and	CCONJ
ecletica-510	23	26	ii	ii	PROPN
ecletica-510	23	27	clinical	clinical	ADJ
ecletica-510	23	28	trials	trial	NOUN
ecletica-510	23	29	because	because	SCONJ
ecletica-510	23	30	of	of	ADP
ecletica-510	23	31	its	its	PRON
ecletica-510	23	32	antiproliferative	antiproliferative	ADJ
ecletica-510	23	33	properties	property	NOUN
ecletica-510	23	34	.	.	PUNCT
ecletica-510	24	1	treatment	treatment	NOUN
ecletica-510	24	2	with	with	ADP
ecletica-510	24	3	flavopiridol	flavopiridol	NOUN
ecletica-510	24	4	resulted	result	VERB
ecletica-510	24	5	in	in	ADP
ecletica-510	24	6	blocking	block	VERB
ecletica-510	24	7	cell	cell	NOUN
ecletica-510	24	8	cycle	cycle	NOUN
ecletica-510	24	9	progression	progression	NOUN
ecletica-510	24	10	,	,	PUNCT
ecletica-510	24	11	promoting	promote	VERB
ecletica-510	24	12	differentiation	differentiation	NOUN
ecletica-510	24	13	and	and	CCONJ
ecletica-510	24	14	inducing	induce	VERB
ecletica-510	24	15	apoptosis	apoptosis	NOUN
ecletica-510	24	16	in	in	ADP
ecletica-510	24	17	various	various	ADJ
ecletica-510	24	18	types	type	NOUN
ecletica-510	24	19	of	of	ADP
ecletica-510	24	20	cancerous	cancerous	ADJ
ecletica-510	24	21	cells	cell	NOUN
ecletica-510	24	22	[	[	X
ecletica-510	24	23	40	40	NUM
ecletica-510	24	24	]	]	PUNCT
ecletica-510	24	25	.	.	PUNCT
ecletica-510	25	1	the	the	DET
ecletica-510	25	2	structure	structure	NOUN
ecletica-510	25	3	of	of	ADP
ecletica-510	25	4	cdk2	cdk2	PROPN
ecletica-510	25	5	complexed	complexe	VERB
ecletica-510	25	6	with	with	ADP
ecletica-510	25	7	deschloroflavopiridol	deschloroflavopiridol	NOUN
ecletica-510	25	8	revealed	reveal	VERB
ecletica-510	25	9	that	that	SCONJ
ecletica-510	25	10	the	the	DET
ecletica-510	25	11	drug	drug	NOUN
ecletica-510	25	12	docks	dock	NOUN
ecletica-510	25	13	in	in	ADP
ecletica-510	25	14	the	the	DET
ecletica-510	25	15	atp	atp	NOUN
ecletica-510	25	16	binding	bind	VERB
ecletica-510	25	17	site	site	NOUN
ecletica-510	25	18	[	[	X
ecletica-510	25	19	17	17	NUM
ecletica-510	25	20	]	]	PUNCT
ecletica-510	25	21	,	,	PUNCT
ecletica-510	25	22	which	which	PRON
ecletica-510	25	23	helps	help	VERB
ecletica-510	25	24	to	to	PART
ecletica-510	25	25	explain	explain	VERB
ecletica-510	25	26	why	why	SCONJ
ecletica-510	25	27	inhibition	inhibition	NOUN
ecletica-510	25	28	of	of	ADP
ecletica-510	25	29	cdk2	cdk2	PROPN
ecletica-510	25	30	is	be	AUX
ecletica-510	25	31	competitive	competitive	ADJ
ecletica-510	25	32	with	with	ADP
ecletica-510	25	33	atp	atp	PROPN
ecletica-510	25	34	.	.	PUNCT
ecletica-510	26	1	two	two	NUM
ecletica-510	26	2	previous	previous	ADJ
ecletica-510	26	3	studies	study	NOUN
ecletica-510	26	4	demonstrated	demonstrate	VERB
ecletica-510	26	5	the	the	DET
ecletica-510	26	6	effect	effect	NOUN
ecletica-510	26	7	of	of	ADP
ecletica-510	26	8	flavopiridol	flavopiridol	NOUN
ecletica-510	26	9	on	on	ADP
ecletica-510	26	10	transcription	transcription	NOUN
ecletica-510	26	11	.	.	PUNCT
ecletica-510	27	1	mammalian	mammalian	ADJ
ecletica-510	27	2	cells	cell	NOUN
ecletica-510	27	3	treated	treat	VERB
ecletica-510	27	4	with	with	ADP
ecletica-510	27	5	this	this	DET
ecletica-510	27	6	compound	compound	NOUN
ecletica-510	27	7	showed	show	VERB
ecletica-510	27	8	decreased	decrease	VERB
ecletica-510	27	9	transcription	transcription	NOUN
ecletica-510	27	10	of	of	ADP
ecletica-510	27	11	the	the	DET
ecletica-510	27	12	gene	gene	NOUN
ecletica-510	27	13	encoding	encode	VERB
ecletica-510	27	14	cyclin	cyclin	NOUN
ecletica-510	27	15	d1	d1	PROPN
ecletica-510	28	1	[	[	X
ecletica-510	28	2	8	8	NUM
ecletica-510	28	3	]	]	PUNCT
ecletica-510	28	4	,	,	PUNCT
ecletica-510	28	5	and	and	CCONJ
ecletica-510	28	6	high	high	ADJ
ecletica-510	28	7	levels	level	NOUN
ecletica-510	28	8	of	of	ADP
ecletica-510	28	9	flavopiridol	flavopiridol	NOUN
ecletica-510	28	10	affected	affect	VERB
ecletica-510	28	11	levels	level	NOUN
ecletica-510	28	12	of	of	ADP
ecletica-510	28	13	63	63	NUM
ecletica-510	28	14	different	different	ADJ
ecletica-510	28	15	mrnas	mrna	NOUN
ecletica-510	28	16	in	in	ADP
ecletica-510	28	17	saccharomyces	saccharomyce	NOUN
ecletica-510	28	18	cerevisiae	cerevisiae	NOUN
ecletica-510	28	19	[	[	X
ecletica-510	28	20	21	21	NUM
ecletica-510	28	21	]	]	PUNCT
ecletica-510	28	22	.	.	PUNCT
ecletica-510	29	1	the	the	DET
ecletica-510	29	2	transcriptional	transcriptional	NOUN
ecletica-510	29	3	inhibition	inhibition	NOUN
ecletica-510	29	4	observed	observe	VERB
ecletica-510	29	5	in	in	ADP
ecletica-510	29	6	these	these	DET
ecletica-510	29	7	studies	study	NOUN
ecletica-510	29	8	could	could	AUX
ecletica-510	29	9	have	have	AUX
ecletica-510	29	10	been	be	AUX
ecletica-510	29	11	direct	direct	ADJ
ecletica-510	29	12	or	or	CCONJ
ecletica-510	29	13	a	a	DET
ecletica-510	29	14	consequence	consequence	NOUN
ecletica-510	29	15	of	of	ADP
ecletica-510	29	16	altered	altered	ADJ
ecletica-510	29	17	progression	progression	NOUN
ecletica-510	29	18	through	through	ADP
ecletica-510	29	19	the	the	DET
ecletica-510	29	20	cell	cell	NOUN
ecletica-510	29	21	cycle	cycle	NOUN
ecletica-510	29	22	.	.	PUNCT
ecletica-510	30	1	furthermore	furthermore	ADV
ecletica-510	30	2	,	,	PUNCT
ecletica-510	30	3	it	it	PRON
ecletica-510	30	4	has	have	AUX
ecletica-510	30	5	been	be	AUX
ecletica-510	30	6	shown	show	VERB
ecletica-510	30	7	that	that	SCONJ
ecletica-510	30	8	the	the	DET
ecletica-510	30	9	binary	binary	PROPN
ecletica-510	30	10	complex	complex	PROPN
ecletica-510	30	11	cdk9	cdk9	PROPN
ecletica-510	30	12	-	-	PUNCT
ecletica-510	30	13	cyclin	cyclin	PROPN
ecletica-510	30	14	t1	t1	NOUN
ecletica-510	30	15	is	be	AUX
ecletica-510	30	16	potently	potently	ADV
ecletica-510	30	17	inhibited	inhibit	VERB
ecletica-510	30	18	by	by	ADP
ecletica-510	30	19	flavopiridol	flavopiridol	NOUN
ecletica-510	30	20	[	[	X
ecletica-510	30	21	9	9	NUM
ecletica-510	30	22	]	]	PUNCT
ecletica-510	30	23	.	.	PUNCT
ecletica-510	31	1	these	these	DET
ecletica-510	31	2	results	result	NOUN
ecletica-510	31	3	demonstrated	demonstrate	VERB
ecletica-510	31	4	that	that	SCONJ
ecletica-510	31	5	flavopiridol	flavopiridol	NOUN
ecletica-510	31	6	inhibited	inhibit	VERB
ecletica-510	31	7	the	the	DET
ecletica-510	31	8	complex	complex	ADJ
ecletica-510	31	9	cdk9	cdk9	PROPN
ecletica-510	31	10	-	-	PUNCT
ecletica-510	31	11	cyclin	cyclin	NOUN
ecletica-510	31	12	t1	t1	NOUN
ecletica-510	31	13	causing	cause	VERB
ecletica-510	31	14	inhibition	inhibition	NOUN
ecletica-510	31	15	of	of	ADP
ecletica-510	31	16	transcription	transcription	NOUN
ecletica-510	31	17	.	.	PUNCT
ecletica-510	32	1	the	the	DET
ecletica-510	32	2	properties	property	NOUN
ecletica-510	32	3	of	of	ADP
ecletica-510	32	4	the	the	DET
ecletica-510	32	5	flavopiridol	flavopiridol	NOUN
ecletica-510	32	6	towards	towards	ADP
ecletica-510	32	7	the	the	DET
ecletica-510	32	8	cdk9	cdk9	PROPN
ecletica-510	32	9	-	-	PUNCT
ecletica-510	32	10	cyclin	cyclin	PROPN
ecletica-510	32	11	t1	t1	PROPN
ecletica-510	32	12	complex	complex	PROPN
ecletica-510	32	13	suggest	suggest	VERB
ecletica-510	32	14	that	that	SCONJ
ecletica-510	32	15	it	it	PRON
ecletica-510	32	16	should	should	AUX
ecletica-510	32	17	be	be	AUX
ecletica-510	32	18	examined	examine	VERB
ecletica-510	32	19	its	its	PRON
ecletica-510	32	20	potential	potential	ADJ
ecletica-510	32	21	use	use	NOUN
ecletica-510	32	22	in	in	ADP
ecletica-510	32	23	hiv-1	hiv-1	ADJ
ecletica-510	32	24	therapy	therapy	NOUN
ecletica-510	32	25	[	[	X
ecletica-510	32	26	9,14	9,14	NUM
ecletica-510	32	27	]	]	PUNCT
ecletica-510	32	28	.	.	PUNCT
ecletica-510	33	1	roscovitine	roscovitine	PROPN
ecletica-510	33	2	is	be	AUX
ecletica-510	33	3	a	a	DET
ecletica-510	33	4	potent	potent	ADJ
ecletica-510	33	5	cdk	cdk	NOUN
ecletica-510	33	6	inhibitor	inhibitor	NOUN
ecletica-510	33	7	and	and	CCONJ
ecletica-510	33	8	was	be	AUX
ecletica-510	33	9	tested	test	VERB
ecletica-510	33	10	against	against	ADP
ecletica-510	33	11	various	various	ADJ
ecletica-510	33	12	cdks	cdks	NOUN
ecletica-510	33	13	,	,	PUNCT
ecletica-510	33	14	with	with	ADP
ecletica-510	33	15	ic50	ic50	PROPN
ecletica-510	33	16	values	value	NOUN
ecletica-510	33	17	ranging	range	VERB
ecletica-510	33	18	from	from	ADP
ecletica-510	33	19	0.16	0.16	NUM
ecletica-510	33	20	mm	mm	NOUN
ecletica-510	33	21	(	(	PUNCT
ecletica-510	33	22	for	for	ADP
ecletica-510	33	23	cdk5	cdk5	PROPN
ecletica-510	33	24	)	)	PUNCT
ecletica-510	34	1	[	[	X
ecletica-510	34	2	15	15	NUM
ecletica-510	34	3	]	]	PUNCT
ecletica-510	34	4	to	to	ADP
ecletica-510	34	5	over	over	ADP
ecletica-510	34	6	100	100	NUM
ecletica-510	34	7	mm	mm	NOUN
ecletica-510	34	8	(	(	PUNCT
ecletica-510	34	9	for	for	ADP
ecletica-510	34	10	cdk4	cdk4	NOUN
ecletica-510	34	11	and	and	CCONJ
ecletica-510	34	12	cdk6	cdk6	PROPN
ecletica-510	34	13	)	)	PUNCT
ecletica-510	35	1	[	[	X
ecletica-510	35	2	28	28	NUM
ecletica-510	35	3	]	]	PUNCT
ecletica-510	35	4	.	.	PUNCT
ecletica-510	36	1	this	this	DET
ecletica-510	36	2	article	article	NOUN
ecletica-510	36	3	describes	describe	VERB
ecletica-510	36	4	the	the	DET
ecletica-510	36	5	modeling	modeling	NOUN
ecletica-510	36	6	of	of	ADP
ecletica-510	36	7	the	the	DET
ecletica-510	36	8	human	human	ADJ
ecletica-510	36	9	cdk9	cdk9	NOUN
ecletica-510	36	10	complexed	complexe	VERB
ecletica-510	36	11	with	with	ADP
ecletica-510	36	12	flavopiridol	flavopiridol	NOUN
ecletica-510	36	13	,	,	PUNCT
ecletica-510	36	14	cdk5	cdk5	PROPN
ecletica-510	36	15	complexed	complexe	VERB
ecletica-510	36	16	with	with	ADP
ecletica-510	36	17	roscovitine	roscovitine	NOUN
ecletica-510	36	18	,	,	PUNCT
ecletica-510	36	19	and	and	CCONJ
ecletica-510	36	20	cdk1	cdk1	PROPN
ecletica-510	36	21	complexed	complexe	VERB
ecletica-510	36	22	with	with	ADP
ecletica-510	36	23	roscovitine	roscovitine	NOUN
ecletica-510	36	24	and	and	CCONJ
ecletica-510	36	25	flavopiridol	flavopiridol	NOUN
ecletica-510	36	26	.	.	PUNCT
ecletica-510	37	1	the	the	DET
ecletica-510	37	2	investigation	investigation	NOUN
ecletica-510	37	3	was	be	AUX
ecletica-510	37	4	made	make	VERB
ecletica-510	37	5	in	in	ADP
ecletica-510	37	6	order	order	NOUN
ecletica-510	37	7	to	to	PART
ecletica-510	37	8	gain	gain	VERB
ecletica-510	37	9	further	further	ADJ
ecletica-510	37	10	insight	insight	NOUN
ecletica-510	37	11	into	into	ADP
ecletica-510	37	12	the	the	DET
ecletica-510	37	13	structural	structural	ADJ
ecletica-510	37	14	basis	basis	NOUN
ecletica-510	37	15	for	for	ADP
ecletica-510	37	16	chemical	chemical	ADJ
ecletica-510	37	17	inhibition	inhibition	NOUN
ecletica-510	37	18	of	of	ADP
ecletica-510	37	19	cdks	cdks	NOUN
ecletica-510	37	20	by	by	ADP
ecletica-510	37	21	flavopiridol	flavopiridol	NOUN
ecletica-510	37	22	and	and	CCONJ
ecletica-510	37	23	roscovitine	roscovitine	NOUN
ecletica-510	37	24	.	.	PUNCT
ecletica-510	38	1	methods	method	NOUN
ecletica-510	38	2	molecular	molecular	ADJ
ecletica-510	38	3	modeling	model	VERB
ecletica-510	38	4	homology	homology	NOUN
ecletica-510	38	5	modeling	modeling	NOUN
ecletica-510	38	6	is	be	AUX
ecletica-510	38	7	usually	usually	ADV
ecletica-510	38	8	the	the	DET
ecletica-510	38	9	method	method	NOUN
ecletica-510	38	10	of	of	ADP
ecletica-510	38	11	choice	choice	NOUN
ecletica-510	38	12	when	when	SCONJ
ecletica-510	38	13	there	there	PRON
ecletica-510	38	14	is	be	VERB
ecletica-510	38	15	a	a	DET
ecletica-510	38	16	clear	clear	ADJ
ecletica-510	38	17	relationship	relationship	NOUN
ecletica-510	38	18	of	of	ADP
ecletica-510	38	19	homology	homology	NOUN
ecletica-510	38	20	between	between	ADP
ecletica-510	38	21	the	the	DET
ecletica-510	38	22	sequence	sequence	NOUN
ecletica-510	38	23	of	of	ADP
ecletica-510	38	24	a	a	DET
ecletica-510	38	25	target	target	NOUN
ecletica-510	38	26	protein	protein	NOUN
ecletica-510	38	27	and	and	CCONJ
ecletica-510	38	28	at	at	ADV
ecletica-510	38	29	least	least	ADJ
ecletica-510	38	30	one	one	NUM
ecletica-510	38	31	known	know	VERB
ecletica-510	38	32	structure	structure	NOUN
ecletica-510	38	33	.	.	PUNCT
ecletica-510	39	1	this	this	DET
ecletica-510	39	2	computational	computational	ADJ
ecletica-510	39	3	technique	technique	NOUN
ecletica-510	39	4	is	be	AUX
ecletica-510	39	5	based	base	VERB
ecletica-510	39	6	on	on	ADP
ecletica-510	39	7	the	the	DET
ecletica-510	39	8	assumption	assumption	NOUN
ecletica-510	39	9	that	that	SCONJ
ecletica-510	39	10	the	the	DET
ecletica-510	39	11	tertiary	tertiary	ADJ
ecletica-510	39	12	structures	structure	NOUN
ecletica-510	39	13	of	of	ADP
ecletica-510	39	14	two	two	NUM
ecletica-510	39	15	proteins	protein	NOUN
ecletica-510	39	16	will	will	AUX
ecletica-510	39	17	be	be	AUX
ecletica-510	39	18	similar	similar	ADJ
ecletica-510	39	19	if	if	SCONJ
ecletica-510	39	20	their	their	PRON
ecletica-510	39	21	sequences	sequence	NOUN
ecletica-510	39	22	are	be	AUX
ecletica-510	39	23	related	relate	VERB
ecletica-510	39	24	,	,	PUNCT
ecletica-510	39	25	and	and	CCONJ
ecletica-510	39	26	it	it	PRON
ecletica-510	39	27	is	be	AUX
ecletica-510	39	28	the	the	DET
ecletica-510	39	29	approach	approach	NOUN
ecletica-510	39	30	most	most	ADV
ecletica-510	39	31	likely	likely	ADJ
ecletica-510	39	32	to	to	PART
ecletica-510	39	33	give	give	VERB
ecletica-510	39	34	accurate	accurate	ADJ
ecletica-510	39	35	results	result	NOUN
ecletica-510	39	36	[	[	X
ecletica-510	39	37	25	25	NUM
ecletica-510	39	38	]	]	PUNCT
ecletica-510	39	39	.	.	PUNCT
ecletica-510	40	1	there	there	PRON
ecletica-510	40	2	are	be	VERB
ecletica-510	40	3	two	two	NUM
ecletica-510	40	4	main	main	ADJ
ecletica-510	40	5	approaches	approach	NOUN
ecletica-510	40	6	to	to	PART
ecletica-510	40	7	homology	homology	VERB
ecletica-510	40	8	modeling	modeling	NOUN
ecletica-510	40	9	:	:	PUNCT
ecletica-510	40	10	1	1	NUM
ecletica-510	40	11	)	)	PUNCT
ecletica-510	40	12	fragment	fragment	NOUN
ecletica-510	40	13	-	-	PUNCT
ecletica-510	40	14	based	base	VERB
ecletica-510	40	15	comparative	comparative	ADJ
ecletica-510	40	16	modeling	modeling	NOUN
ecletica-510	40	17	[	[	X
ecletica-510	40	18	4	4	NUM
ecletica-510	40	19	,	,	PUNCT
ecletica-510	40	20	3	3	NUM
ecletica-510	40	21	]	]	PUNCT
ecletica-510	40	22	and	and	CCONJ
ecletica-510	40	23	2	2	X
ecletica-510	40	24	)	)	PUNCT
ecletica-510	40	25	restrained	restrain	VERB
ecletica-510	40	26	-	-	PUNCT
ecletica-510	40	27	based	base	VERB
ecletica-510	40	28	modeling	modeling	NOUN
ecletica-510	40	29	[	[	X
ecletica-510	40	30	36	36	NUM
ecletica-510	40	31	]	]	PUNCT
ecletica-510	40	32	.	.	PUNCT
ecletica-510	41	1	for	for	ADP
ecletica-510	41	2	modeling	modeling	NOUN
ecletica-510	41	3	of	of	ADP
ecletica-510	41	4	the	the	DET
ecletica-510	41	5	cdks	cdks	NOUN
ecletica-510	41	6	:	:	PUNCT
ecletica-510	41	7	inhibitor	inhibitor	NOUN
ecletica-510	41	8	complexes	complex	NOUN
ecletica-510	41	9	we	we	PRON
ecletica-510	41	10	used	use	VERB
ecletica-510	41	11	the	the	DET
ecletica-510	41	12	second	second	ADJ
ecletica-510	41	13	approach	approach	NOUN
ecletica-510	41	14	.	.	PUNCT
ecletica-510	42	1	model	model	NOUN
ecletica-510	42	2	building	building	PROPN
ecletica-510	42	3	of	of	ADP
ecletica-510	42	4	cdks	cdks	ADJ
ecletica-510	42	5	:	:	PUNCT
ecletica-510	42	6	inhibitor	inhibitor	NOUN
ecletica-510	42	7	was	be	AUX
ecletica-510	42	8	carried	carry	VERB
ecletica-510	42	9	out	out	ADP
ecletica-510	42	10	using	use	VERB
ecletica-510	42	11	the	the	DET
ecletica-510	42	12	program	program	NOUN
ecletica-510	42	13	modeller	modeller	NOUN
ecletica-510	42	14	[	[	X
ecletica-510	42	15	36	36	NUM
ecletica-510	42	16	]	]	PUNCT
ecletica-510	42	17	.	.	PUNCT
ecletica-510	43	1	modeller	modeller	PROPN
ecletica-510	43	2	is	be	AUX
ecletica-510	43	3	an	an	DET
ecletica-510	43	4	implementation	implementation	NOUN
ecletica-510	43	5	of	of	ADP
ecletica-510	43	6	an	an	DET
ecletica-510	43	7	automated	automate	VERB
ecletica-510	43	8	approach	approach	NOUN
ecletica-510	43	9	to	to	ADP
ecletica-510	43	10	comparative	comparative	VERB
ecletica-510	43	11	modeling	modeling	NOUN
ecletica-510	43	12	by	by	ADP
ecletica-510	43	13	satisfaction	satisfaction	NOUN
ecletica-510	43	14	of	of	ADP
ecletica-510	43	15	spatial	spatial	ADJ
ecletica-510	43	16	restraints	restraint	NOUN
ecletica-510	43	17	[	[	X
ecletica-510	43	18	37	37	NUM
ecletica-510	43	19	,	,	PUNCT
ecletica-510	43	20	38	38	NUM
ecletica-510	43	21	,	,	PUNCT
ecletica-510	43	22	35	35	NUM
ecletica-510	43	23	]	]	PUNCT
ecletica-510	43	24	.	.	PUNCT
ecletica-510	44	1	the	the	DET
ecletica-510	44	2	modeling	modeling	NOUN
ecletica-510	44	3	procedure	procedure	NOUN
ecletica-510	44	4	begins	begin	VERB
ecletica-510	44	5	with	with	ADP
ecletica-510	44	6	an	an	DET
ecletica-510	44	7	alignment	alignment	NOUN
ecletica-510	44	8	of	of	ADP
ecletica-510	44	9	the	the	DET
ecletica-510	44	10	sequence	sequence	NOUN
ecletica-510	44	11	to	to	PART
ecletica-510	44	12	be	be	AUX
ecletica-510	44	13	modeled	model	VERB
ecletica-510	44	14	(	(	PUNCT
ecletica-510	44	15	target	target	NOUN
ecletica-510	44	16	)	)	PUNCT
ecletica-510	44	17	with	with	ADP
ecletica-510	44	18	related	related	ADJ
ecletica-510	44	19	known	know	VERB
ecletica-510	44	20	three	three	NUM
ecletica-510	44	21	-	-	PUNCT
ecletica-510	44	22	dimensional	dimensional	ADJ
ecletica-510	44	23	structures	structure	NOUN
ecletica-510	44	24	(	(	PUNCT
ecletica-510	44	25	templates	template	NOUN
ecletica-510	44	26	)	)	PUNCT
ecletica-510	44	27	.	.	PUNCT
ecletica-510	45	1	this	this	DET
ecletica-510	45	2	alignment	alignment	NOUN
ecletica-510	45	3	is	be	AUX
ecletica-510	45	4	usually	usually	ADV
ecletica-510	45	5	the	the	DET
ecletica-510	45	6	input	input	NOUN
ecletica-510	45	7	to	to	ADP
ecletica-510	45	8	the	the	DET
ecletica-510	45	9	program	program	NOUN
ecletica-510	45	10	.	.	PUNCT
ecletica-510	46	1	the	the	DET
ecletica-510	46	2	output	output	NOUN
ecletica-510	46	3	is	be	AUX
ecletica-510	46	4	a	a	DET
ecletica-510	46	5	three	three	NUM
ecletica-510	46	6	-	-	PUNCT
ecletica-510	46	7	dimensional	dimensional	ADJ
ecletica-510	46	8	model	model	NOUN
ecletica-510	46	9	for	for	ADP
ecletica-510	46	10	the	the	DET
ecletica-510	46	11	target	target	NOUN
ecletica-510	46	12	sequence	sequence	NOUN
ecletica-510	46	13	containing	contain	VERB
ecletica-510	46	14	all	all	DET
ecletica-510	46	15	mainchain	mainchain	NOUN
ecletica-510	46	16	and	and	CCONJ
ecletica-510	46	17	sidechain	sidechain	NOUN
ecletica-510	46	18	non	non	ADJ
ecletica-510	46	19	-	-	ADJ
ecletica-510	46	20	hydrogen	hydrogen	ADJ
ecletica-510	46	21	atoms	atom	NOUN
ecletica-510	46	22	.	.	PUNCT
ecletica-510	47	1	since	since	SCONJ
ecletica-510	47	2	there	there	PRON
ecletica-510	47	3	is	be	VERB
ecletica-510	47	4	no	no	DET
ecletica-510	47	5	three	three	NUM
ecletica-510	47	6	-	-	PUNCT
ecletica-510	47	7	dimensional	dimensional	ADJ
ecletica-510	47	8	structure	structure	NOUN
ecletica-510	47	9	for	for	ADP
ecletica-510	47	10	cdk2	cdk2	PROPN
ecletica-510	47	11	:	:	PUNCT
ecletica-510	47	12	flavopiridol	flavopiridol	PROPN
ecletica-510	47	13	complex	complex	PROPN
ecletica-510	47	14	available	available	ADJ
ecletica-510	47	15	a	a	DET
ecletica-510	47	16	model	model	NOUN
ecletica-510	47	17	was	be	AUX
ecletica-510	47	18	built	build	VERB
ecletica-510	47	19	based	base	VERB
ecletica-510	47	20	on	on	ADP
ecletica-510	47	21	the	the	DET
ecletica-510	47	22	atomic	atomic	ADJ
ecletica-510	47	23	coordinates	coordinate	NOUN
ecletica-510	47	24	of	of	ADP
ecletica-510	47	25	cdk2	cdk2	PROPN
ecletica-510	47	26	:	:	PUNCT
ecletica-510	47	27	deschloroflavopridol	deschloroflavopridol	NOUN
ecletica-510	47	28	complex	complex	NOUN
ecletica-510	47	29	,	,	PUNCT
ecletica-510	47	30	which	which	PRON
ecletica-510	47	31	was	be	AUX
ecletica-510	47	32	solved	solve	VERB
ecletica-510	47	33	by	by	ADP
ecletica-510	47	34	cryocrystallographic	cryocrystallographic	ADJ
ecletica-510	47	35	methods	method	NOUN
ecletica-510	47	36	[	[	X
ecletica-510	47	37	17	17	NUM
ecletica-510	47	38	]	]	PUNCT
ecletica-510	47	39	.	.	PUNCT
ecletica-510	48	1	the	the	DET
ecletica-510	48	2	flavopiridol	flavopiridol	PROPN
ecletica-510	48	3	coordinates	coordinate	NOUN
ecletica-510	48	4	,	,	PUNCT
ecletica-510	48	5	taken	take	VERB
ecletica-510	48	6	from	from	ADP
ecletica-510	48	7	the	the	DET
ecletica-510	48	8	complex	complex	ADJ
ecletica-510	48	9	glycogen	glycogen	NOUN
ecletica-510	48	10	phosphorylase	phosphorylase	NOUN
ecletica-510	48	11	:	:	PUNCT
ecletica-510	48	12	flavopiridol	flavopiridol	PROPN
ecletica-510	48	13	(	(	PUNCT
ecletica-510	48	14	access	access	PROPN
ecletica-510	48	15	code	code	NOUN
ecletica-510	48	16	:	:	PUNCT
ecletica-510	48	17	1c8k	1c8k	NUM
ecletica-510	48	18	)	)	PUNCT
ecletica-510	48	19	,	,	PUNCT
ecletica-510	48	20	[	[	X
ecletica-510	48	21	32	32	NUM
ecletica-510	48	22	]	]	PUNCT
ecletica-510	48	23	were	be	AUX
ecletica-510	48	24	superposed	superpose	VERB
ecletica-510	48	25	to	to	ADP
ecletica-510	48	26	that	that	PRON
ecletica-510	48	27	of	of	ADP
ecletica-510	48	28	cdk2	cdk2	PROPN
ecletica-510	48	29	:	:	PUNCT
ecletica-510	48	30	deschloroflavopiridol	deschloroflavopiridol	VERB
ecletica-510	48	31	[	[	X
ecletica-510	48	32	17	17	NUM
ecletica-510	48	33	]	]	PUNCT
ecletica-510	48	34	in	in	ADP
ecletica-510	48	35	order	order	NOUN
ecletica-510	48	36	to	to	PART
ecletica-510	48	37	obtain	obtain	VERB
ecletica-510	48	38	the	the	DET
ecletica-510	48	39	cdk2	cdk2	NOUN
ecletica-510	48	40	:	:	PUNCT
ecletica-510	48	41	flavopiridol	flavopiridol	NOUN
ecletica-510	48	42	structure	structure	NOUN
ecletica-510	48	43	.	.	PUNCT
ecletica-510	49	1	the	the	DET
ecletica-510	49	2	atomic	atomic	ADJ
ecletica-510	49	3	coordinates	coordinate	NOUN
ecletica-510	49	4	for	for	ADP
ecletica-510	49	5	cdk2	cdk2	PROPN
ecletica-510	49	6	:	:	PUNCT
ecletica-510	49	7	flavopiridol	flavopiridol	PROPN
ecletica-510	49	8	were	be	AUX
ecletica-510	49	9	used	use	VERB
ecletica-510	49	10	as	as	ADP
ecletica-510	49	11	starting	start	VERB
ecletica-510	49	12	model	model	NOUN
ecletica-510	49	13	for	for	ADP
ecletica-510	49	14	modeling	modeling	NOUN
ecletica-510	49	15	of	of	ADP
ecletica-510	49	16	the	the	DET
ecletica-510	49	17	cdk9	cdk9	PROPN
ecletica-510	49	18	and	and	CCONJ
ecletica-510	49	19	cdk1	cdk1	PROPN
ecletica-510	49	20	complexed	complexe	VERB
ecletica-510	49	21	with	with	ADP
ecletica-510	49	22	flavopiridol	flavopiridol	NOUN
ecletica-510	49	23	.	.	PUNCT
ecletica-510	50	1	the	the	DET
ecletica-510	50	2	alignment	alignment	NOUN
ecletica-510	50	3	of	of	ADP
ecletica-510	50	4	cdk2	cdk2	PROPN
ecletica-510	50	5	(	(	PUNCT
ecletica-510	50	6	template	template	NOUN
ecletica-510	50	7	)	)	PUNCT
ecletica-510	50	8	,	,	PUNCT
ecletica-510	50	9	cdk1	cdk1	PROPN
ecletica-510	50	10	,	,	PUNCT
ecletica-510	50	11	cdk5	cdk5	PROPN
ecletica-510	50	12	,	,	PUNCT
ecletica-510	50	13	and	and	CCONJ
ecletica-510	50	14	cdk9	cdk9	PROPN
ecletica-510	50	15	is	be	AUX
ecletica-510	50	16	shown	show	VERB
ecletica-510	50	17	in	in	ADP
ecletica-510	50	18	figure	figure	NOUN
ecletica-510	50	19	1	1	NUM
ecletica-510	50	20	.	.	PUNCT
ecletica-510	50	21	fifteen	fifteen	NUM
ecletica-510	50	22	residues	residue	NOUN
ecletica-510	50	23	from	from	ADP
ecletica-510	50	24	the	the	DET
ecletica-510	50	25	n	n	CCONJ
ecletica-510	50	26	-	-	PUNCT
ecletica-510	50	27	terminal	terminal	ADJ
ecletica-510	50	28	and	and	CCONJ
ecletica-510	50	29	45	45	NUM
ecletica-510	50	30	residues	residue	NOUN
ecletica-510	50	31	from	from	ADP
ecletica-510	50	32	the	the	DET
ecletica-510	50	33	c	c	NOUN
ecletica-510	50	34	-	-	PUNCT
ecletica-510	50	35	terminus	terminus	NOUN
ecletica-510	50	36	were	be	AUX
ecletica-510	50	37	removed	remove	VERB
ecletica-510	50	38	from	from	ADP
ecletica-510	50	39	the	the	DET
ecletica-510	50	40	cdk9	cdk9	PROPN
ecletica-510	50	41	model	model	NOUN
ecletica-510	50	42	,	,	PUNCT
ecletica-510	50	43	since	since	SCONJ
ecletica-510	50	44	there	there	PRON
ecletica-510	50	45	is	be	VERB
ecletica-510	50	46	no	no	DET
ecletica-510	50	47	good	good	ADJ
ecletica-510	50	48	template	template	NOUN
ecletica-510	50	49	for	for	ADP
ecletica-510	50	50	these	these	DET
ecletica-510	50	51	fragments	fragment	NOUN
ecletica-510	50	52	,	,	PUNCT
ecletica-510	50	53	for	for	ADP
ecletica-510	50	54	cdk1	cdk1	PROPN
ecletica-510	50	55	and	and	CCONJ
ecletica-510	50	56	cdk5	cdk5	PROPN
ecletica-510	50	57	all	all	DET
ecletica-510	50	58	residues	residue	NOUN
ecletica-510	50	59	were	be	AUX
ecletica-510	50	60	kept	keep	VERB
ecletica-510	50	61	in	in	ADP
ecletica-510	50	62	the	the	DET
ecletica-510	50	63	model	model	NOUN
ecletica-510	50	64	.	.	PUNCT
ecletica-510	51	1	next	next	ADV
ecletica-510	51	2	,	,	PUNCT
ecletica-510	51	3	the	the	DET
ecletica-510	51	4	spatial	spatial	ADJ
ecletica-510	51	5	restraints	restraint	NOUN
ecletica-510	51	6	and	and	CCONJ
ecletica-510	51	7	charmm	charmm	VERB
ecletica-510	51	8	energy	energy	NOUN
ecletica-510	51	9	terms	term	NOUN
ecletica-510	51	10	enforcing	enforce	VERB
ecletica-510	51	11	proper	proper	ADJ
ecletica-510	51	12	stereochemistry	stereochemistry	NOUN
ecletica-510	51	13	[	[	X
ecletica-510	51	14	6	6	NUM
ecletica-510	51	15	]	]	PUNCT
ecletica-510	51	16	were	be	AUX
ecletica-510	51	17	combined	combine	VERB
ecletica-510	51	18	into	into	ADP
ecletica-510	51	19	an	an	DET
ecletica-510	51	20	objective	objective	ADJ
ecletica-510	51	21	function	function	NOUN
ecletica-510	51	22	.	.	PUNCT
ecletica-510	52	1	finally	finally	ADV
ecletica-510	52	2	,	,	PUNCT
ecletica-510	52	3	the	the	DET
ecletica-510	52	4	model	model	NOUN
ecletica-510	52	5	is	be	AUX
ecletica-510	52	6	obtained	obtain	VERB
ecletica-510	52	7	by	by	ADP
ecletica-510	52	8	optimizing	optimize	VERB
ecletica-510	52	9	the	the	DET
ecletica-510	52	10	objective	objective	ADJ
ecletica-510	52	11	function	function	NOUN
ecletica-510	52	12	in	in	ADP
ecletica-510	52	13	cartesian	cartesian	PROPN
ecletica-510	52	14	ecl	ecl	PROPN
ecletica-510	52	15	.	.	PROPN
ecletica-510	52	16	quím	quím	PROPN
ecletica-510	52	17	.	.	PUNCT
ecletica-510	53	1	,	,	PUNCT
ecletica-510	53	2	são	são	PROPN
ecletica-510	53	3	paulo	paulo	PROPN
ecletica-510	53	4	,	,	PUNCT
ecletica-510	53	5	28(1	28(1	NOUN
ecletica-510	53	6	):	):	PUNCT
ecletica-510	53	7	45	45	NUM
ecletica-510	53	8	-	-	SYM
ecletica-510	53	9	53	53	NUM
ecletica-510	53	10	,	,	PUNCT
ecletica-510	53	11	2003	2003	NUM
ecletica-510	53	12	47	47	NUM
ecletica-510	53	13	space	space	NOUN
ecletica-510	53	14	.	.	PUNCT
ecletica-510	54	1	the	the	DET
ecletica-510	54	2	optimization	optimization	NOUN
ecletica-510	54	3	is	be	AUX
ecletica-510	54	4	carried	carry	VERB
ecletica-510	54	5	out	out	ADP
ecletica-510	54	6	by	by	ADP
ecletica-510	54	7	the	the	DET
ecletica-510	54	8	use	use	NOUN
ecletica-510	54	9	of	of	ADP
ecletica-510	54	10	the	the	DET
ecletica-510	54	11	variable	variable	ADJ
ecletica-510	54	12	target	target	NOUN
ecletica-510	54	13	function	function	NOUN
ecletica-510	54	14	method	method	NOUN
ecletica-510	54	15	[	[	X
ecletica-510	54	16	5	5	NUM
ecletica-510	54	17	]	]	PUNCT
ecletica-510	54	18	employing	employ	VERB
ecletica-510	54	19	methods	method	NOUN
ecletica-510	54	20	of	of	ADP
ecletica-510	54	21	conjugate	conjugate	ADJ
ecletica-510	54	22	gradients	gradient	NOUN
ecletica-510	54	23	using	use	VERB
ecletica-510	54	24	the	the	DET
ecletica-510	54	25	program	program	NOUN
ecletica-510	54	26	modeller	modeller	NOUN
ecletica-510	54	27	[	[	X
ecletica-510	54	28	36	36	NUM
ecletica-510	54	29	]	]	PUNCT
ecletica-510	54	30	.	.	PUNCT
ecletica-510	55	1	several	several	ADJ
ecletica-510	55	2	slightly	slightly	ADV
ecletica-510	55	3	different	different	ADJ
ecletica-510	55	4	models	model	NOUN
ecletica-510	55	5	can	can	AUX
ecletica-510	55	6	be	be	AUX
ecletica-510	55	7	calculated	calculate	VERB
ecletica-510	55	8	by	by	ADP
ecletica-510	55	9	varying	vary	VERB
ecletica-510	55	10	the	the	DET
ecletica-510	55	11	initial	initial	ADJ
ecletica-510	55	12	structure	structure	NOUN
ecletica-510	55	13	.	.	PUNCT
ecletica-510	56	1	the	the	DET
ecletica-510	56	2	final	final	ADJ
ecletica-510	56	3	model	model	NOUN
ecletica-510	56	4	is	be	AUX
ecletica-510	56	5	selected	select	VERB
ecletica-510	56	6	based	base	VERB
ecletica-510	56	7	on	on	ADP
ecletica-510	56	8	stereochemical	stereochemical	ADJ
ecletica-510	56	9	quality	quality	NOUN
ecletica-510	56	10	.	.	PUNCT
ecletica-510	57	1	all	all	DET
ecletica-510	57	2	optimization	optimization	NOUN
ecletica-510	57	3	process	process	NOUN
ecletica-510	57	4	was	be	AUX
ecletica-510	57	5	performed	perform	VERB
ecletica-510	57	6	on	on	ADP
ecletica-510	57	7	a	a	DET
ecletica-510	57	8	beowulf	beowulf	PROPN
ecletica-510	57	9	cluster	cluster	NOUN
ecletica-510	57	10	(	(	PUNCT
ecletica-510	57	11	16	16	NUM
ecletica-510	57	12	nodes	node	NOUN
ecletica-510	57	13	,	,	PUNCT
ecletica-510	57	14	amd	amd	PROPN
ecletica-510	57	15	athlon	athlon	NOUN
ecletica-510	57	16	1800	1800	NUM
ecletica-510	57	17	+	+	NUM
ecletica-510	57	18	)	)	PUNCT
ecletica-510	57	19	.	.	PUNCT
ecletica-510	58	1	analysis	analysis	NOUN
ecletica-510	58	2	of	of	ADP
ecletica-510	58	3	the	the	DET
ecletica-510	58	4	model	model	NOUN
ecletica-510	58	5	the	the	DET
ecletica-510	58	6	overall	overall	ADJ
ecletica-510	58	7	stereochemical	stereochemical	ADJ
ecletica-510	58	8	quality	quality	NOUN
ecletica-510	58	9	of	of	ADP
ecletica-510	58	10	the	the	DET
ecletica-510	58	11	final	final	ADJ
ecletica-510	58	12	models	model	NOUN
ecletica-510	58	13	for	for	ADP
ecletica-510	58	14	cdk9	cdk9	NOUN
ecletica-510	58	15	:	:	PUNCT
ecletica-510	58	16	flavopiridol	flavopiridol	PROPN
ecletica-510	58	17	,	,	PUNCT
ecletica-510	58	18	cdk5	cdk5	PROPN
ecletica-510	58	19	:	:	PUNCT
ecletica-510	58	20	roscovitine	roscovitine	NOUN
ecletica-510	58	21	,	,	PUNCT
ecletica-510	58	22	cdk1	cdk1	PROPN
ecletica-510	58	23	:	:	PUNCT
ecletica-510	58	24	roscovitine	roscovitine	ADJ
ecletica-510	58	25	,	,	PUNCT
ecletica-510	58	26	cdk1	cdk1	PROPN
ecletica-510	58	27	:	:	PUNCT
ecletica-510	58	28	flavopiridol	flavopiridol	PROPN
ecletica-510	58	29	were	be	AUX
ecletica-510	58	30	assessed	assess	VERB
ecletica-510	58	31	by	by	ADP
ecletica-510	58	32	the	the	DET
ecletica-510	58	33	program	program	NOUN
ecletica-510	58	34	procheck	procheck	NOUN
ecletica-510	59	1	[	[	X
ecletica-510	59	2	26	26	NUM
ecletica-510	59	3	]	]	PUNCT
ecletica-510	59	4	.	.	PUNCT
ecletica-510	60	1	atomic	atomic	ADJ
ecletica-510	60	2	models	model	NOUN
ecletica-510	60	3	were	be	AUX
ecletica-510	60	4	superposed	superpose	VERB
ecletica-510	60	5	using	use	VERB
ecletica-510	60	6	the	the	DET
ecletica-510	60	7	program	program	NOUN
ecletica-510	60	8	lsqkab	lsqkab	NOUN
ecletica-510	60	9	from	from	ADP
ecletica-510	60	10	ccp4	ccp4	NOUN
ecletica-510	60	11	[	[	X
ecletica-510	60	12	11	11	NUM
ecletica-510	60	13	]	]	PUNCT
ecletica-510	60	14	.	.	PUNCT
ecletica-510	61	1	the	the	DET
ecletica-510	61	2	cutoff	cutoff	NOUN
ecletica-510	61	3	for	for	ADP
ecletica-510	61	4	hydrogen	hydrogen	NOUN
ecletica-510	61	5	bonds	bond	NOUN
ecletica-510	61	6	and	and	CCONJ
ecletica-510	61	7	salt	salt	NOUN
ecletica-510	61	8	bridges	bridge	NOUN
ecletica-510	61	9	was	be	AUX
ecletica-510	61	10	3.4	3.4	NUM
ecletica-510	61	11	å	å	NOUN
ecletica-510	61	12	.	.	PUNCT
ecletica-510	62	1	the	the	DET
ecletica-510	62	2	contact	contact	NOUN
ecletica-510	62	3	surfaces	surface	NOUN
ecletica-510	62	4	for	for	ADP
ecletica-510	62	5	the	the	DET
ecletica-510	62	6	binary	binary	ADJ
ecletica-510	62	7	complexes	complex	NOUN
ecletica-510	62	8	were	be	AUX
ecletica-510	62	9	calculated	calculate	VERB
ecletica-510	62	10	using	use	VERB
ecletica-510	62	11	areaimol	areaimol	PROPN
ecletica-510	62	12	and	and	CCONJ
ecletica-510	62	13	resarea	resarea	VERB
ecletica-510	63	1	[	[	X
ecletica-510	63	2	11	11	NUM
ecletica-510	63	3	]	]	PUNCT
ecletica-510	63	4	.	.	PUNCT
ecletica-510	64	1	results	result	NOUN
ecletica-510	64	2	and	and	CCONJ
ecletica-510	64	3	discussion	discussion	NOUN
ecletica-510	64	4	quality	quality	NOUN
ecletica-510	64	5	of	of	ADP
ecletica-510	64	6	the	the	DET
ecletica-510	64	7	model	model	NOUN
ecletica-510	64	8	ramachandran	ramachandran	PROPN
ecletica-510	64	9	diagram	diagram	PROPN
ecletica-510	64	10	f	f	PROPN
ecletica-510	64	11	-	-	PUNCT
ecletica-510	64	12	y	y	PROPN
ecletica-510	64	13	plots	plot	VERB
ecletica-510	64	14	for	for	ADP
ecletica-510	64	15	the	the	DET
ecletica-510	64	16	binary	binary	ADJ
ecletica-510	64	17	complexes	complex	NOUN
ecletica-510	64	18	of	of	ADP
ecletica-510	64	19	cdk	cdk	NOUN
ecletica-510	64	20	models	model	NOUN
ecletica-510	64	21	and	and	CCONJ
ecletica-510	64	22	for	for	ADP
ecletica-510	64	23	eight	eight	NUM
ecletica-510	64	24	crystallographic	crystallographic	ADJ
ecletica-510	64	25	cdk2	cdk2	PROPN
ecletica-510	64	26	structures	structure	NOUN
ecletica-510	64	27	solved	solve	VERB
ecletica-510	64	28	to	to	PART
ecletica-510	64	29	resolution	resolution	NOUN
ecletica-510	64	30	better	well	ADV
ecletica-510	64	31	than	than	ADP
ecletica-510	64	32	2.1	2.1	NUM
ecletica-510	64	33	å	å	NOUN
ecletica-510	64	34	were	be	AUX
ecletica-510	64	35	generated	generate	VERB
ecletica-510	64	36	(	(	PUNCT
ecletica-510	64	37	figures	figure	NOUN
ecletica-510	64	38	not	not	PART
ecletica-510	64	39	shown	show	VERB
ecletica-510	64	40	)	)	PUNCT
ecletica-510	64	41	.	.	PUNCT
ecletica-510	65	1	the	the	DET
ecletica-510	65	2	ramachandran	ramachandran	PROPN
ecletica-510	65	3	plot	plot	NOUN
ecletica-510	65	4	,	,	PUNCT
ecletica-510	65	5	for	for	ADP
ecletica-510	65	6	the	the	DET
ecletica-510	65	7	eight	eight	NUM
ecletica-510	65	8	cdk2	cdk2	PROPN
ecletica-510	65	9	structures	structure	NOUN
ecletica-510	65	10	,	,	PUNCT
ecletica-510	65	11	was	be	AUX
ecletica-510	65	12	used	use	VERB
ecletica-510	65	13	to	to	PART
ecletica-510	65	14	compare	compare	VERB
ecletica-510	65	15	the	the	DET
ecletica-510	65	16	overall	overall	ADJ
ecletica-510	65	17	stereochemical	stereochemical	ADJ
ecletica-510	65	18	quality	quality	NOUN
ecletica-510	65	19	of	of	ADP
ecletica-510	65	20	cdks	cdks	ADJ
ecletica-510	65	21	models	model	NOUN
ecletica-510	65	22	against	against	ADP
ecletica-510	65	23	cdk2	cdk2	PROPN
ecletica-510	65	24	structures	structure	NOUN
ecletica-510	65	25	solved	solve	VERB
ecletica-510	65	26	by	by	ADP
ecletica-510	65	27	biocrystallography	biocrystallography	NOUN
ecletica-510	65	28	.	.	PUNCT
ecletica-510	66	1	analysis	analysis	NOUN
ecletica-510	66	2	of	of	ADP
ecletica-510	66	3	the	the	DET
ecletica-510	66	4	ramachandran	ramachandran	PROPN
ecletica-510	66	5	plot	plot	NOUN
ecletica-510	66	6	for	for	ADP
ecletica-510	66	7	the	the	DET
ecletica-510	66	8	cdk9	cdk9	PROPN
ecletica-510	66	9	model	model	NOUN
ecletica-510	66	10	shows	show	VERB
ecletica-510	66	11	that	that	SCONJ
ecletica-510	66	12	78.4	78.4	NUM
ecletica-510	66	13	%	%	NOUN
ecletica-510	66	14	of	of	ADP
ecletica-510	66	15	the	the	DET
ecletica-510	66	16	residues	residue	NOUN
ecletica-510	66	17	lie	lie	VERB
ecletica-510	66	18	in	in	ADP
ecletica-510	66	19	the	the	DET
ecletica-510	66	20	most	most	ADV
ecletica-510	66	21	favorable	favorable	ADJ
ecletica-510	66	22	regions	region	NOUN
ecletica-510	66	23	and	and	CCONJ
ecletica-510	66	24	the	the	DET
ecletica-510	66	25	remaining	remain	VERB
ecletica-510	66	26	21.6	21.6	NUM
ecletica-510	66	27	%	%	NOUN
ecletica-510	66	28	in	in	ADP
ecletica-510	66	29	the	the	DET
ecletica-510	66	30	additional	additional	ADJ
ecletica-510	66	31	allowed	allow	VERB
ecletica-510	66	32	regions	region	NOUN
ecletica-510	66	33	,	,	PUNCT
ecletica-510	66	34	the	the	DET
ecletica-510	66	35	cdk5	cdk5	PROPN
ecletica-510	66	36	model	model	NOUN
ecletica-510	66	37	shows	show	VERB
ecletica-510	66	38	that	that	SCONJ
ecletica-510	66	39	91.0	91.0	NUM
ecletica-510	66	40	%	%	NOUN
ecletica-510	66	41	of	of	ADP
ecletica-510	66	42	the	the	DET
ecletica-510	66	43	residues	residue	NOUN
ecletica-510	66	44	lie	lie	VERB
ecletica-510	66	45	in	in	ADP
ecletica-510	66	46	the	the	DET
ecletica-510	66	47	most	most	ADV
ecletica-510	66	48	favorable	favorable	ADJ
ecletica-510	66	49	regions	region	NOUN
ecletica-510	66	50	,	,	PUNCT
ecletica-510	66	51	8.2	8.2	NUM
ecletica-510	66	52	%	%	NOUN
ecletica-510	66	53	in	in	ADP
ecletica-510	66	54	the	the	DET
ecletica-510	66	55	additional	additional	ADJ
ecletica-510	66	56	allowed	allow	VERB
ecletica-510	66	57	regions	region	NOUN
ecletica-510	66	58	,	,	PUNCT
ecletica-510	66	59	and	and	CCONJ
ecletica-510	66	60	0.8	0.8	NUM
ecletica-510	66	61	%	%	NOUN
ecletica-510	66	62	in	in	ADP
ecletica-510	66	63	the	the	DET
ecletica-510	66	64	disallowed	disallow	VERB
ecletica-510	66	65	regions	region	NOUN
ecletica-510	66	66	(	(	PUNCT
ecletica-510	66	67	asp	asp	PROPN
ecletica-510	66	68	97	97	NUM
ecletica-510	66	69	and	and	CCONJ
ecletica-510	66	70	ala	ala	PROPN
ecletica-510	66	71	198	198	NUM
ecletica-510	66	72	)	)	PUNCT
ecletica-510	66	73	,	,	PUNCT
ecletica-510	66	74	and	and	CCONJ
ecletica-510	66	75	the	the	DET
ecletica-510	66	76	cdk1	cdk1	PROPN
ecletica-510	66	77	model	model	NOUN
ecletica-510	66	78	shows	show	VERB
ecletica-510	66	79	that	that	SCONJ
ecletica-510	66	80	90.8	90.8	NUM
ecletica-510	66	81	%	%	NOUN
ecletica-510	66	82	of	of	ADP
ecletica-510	66	83	the	the	DET
ecletica-510	66	84	residues	residue	NOUN
ecletica-510	66	85	lie	lie	VERB
ecletica-510	66	86	in	in	ADP
ecletica-510	66	87	the	the	DET
ecletica-510	66	88	most	most	ADV
ecletica-510	66	89	favorable	favorable	ADJ
ecletica-510	66	90	regions	region	NOUN
ecletica-510	66	91	and	and	CCONJ
ecletica-510	66	92	9.2	9.2	NUM
ecletica-510	66	93	%	%	NOUN
ecletica-510	66	94	in	in	ADP
ecletica-510	66	95	the	the	DET
ecletica-510	66	96	additional	additional	ADJ
ecletica-510	66	97	allowed	allow	VERB
ecletica-510	66	98	regions	region	NOUN
ecletica-510	66	99	.	.	PUNCT
ecletica-510	67	1	the	the	DET
ecletica-510	67	2	same	same	ADJ
ecletica-510	67	3	analysis	analysis	NOUN
ecletica-510	67	4	for	for	ADP
ecletica-510	67	5	eight	eight	NUM
ecletica-510	67	6	crystallographic	crystallographic	ADJ
ecletica-510	67	7	cdk2	cdk2	PROPN
ecletica-510	67	8	structures	structure	NOUN
ecletica-510	67	9	present	present	VERB
ecletica-510	67	10	89.8	89.8	NUM
ecletica-510	67	11	%	%	NOUN
ecletica-510	67	12	of	of	ADP
ecletica-510	67	13	residues	residue	NOUN
ecletica-510	67	14	in	in	ADP
ecletica-510	67	15	the	the	DET
ecletica-510	67	16	most	most	ADV
ecletica-510	67	17	favorable	favorable	ADJ
ecletica-510	67	18	,	,	PUNCT
ecletica-510	67	19	9.7	9.7	NUM
ecletica-510	67	20	%	%	NOUN
ecletica-510	67	21	in	in	ADP
ecletica-510	67	22	additional	additional	ADJ
ecletica-510	67	23	allowed	allow	VERB
ecletica-510	67	24	regions	region	NOUN
ecletica-510	67	25	,	,	PUNCT
ecletica-510	67	26	and	and	CCONJ
ecletica-510	67	27	0.5	0.5	NUM
ecletica-510	67	28	%	%	NOUN
ecletica-510	67	29	in	in	ADP
ecletica-510	67	30	generously	generously	ADV
ecletica-510	67	31	allowed	allow	VERB
ecletica-510	67	32	regions	region	NOUN
ecletica-510	67	33	.	.	PUNCT
ecletica-510	68	1	overall	overall	ADJ
ecletica-510	68	2	description	description	NOUN
ecletica-510	68	3	the	the	DET
ecletica-510	68	4	models	model	NOUN
ecletica-510	68	5	of	of	ADP
ecletica-510	68	6	the	the	DET
ecletica-510	68	7	kinase	kinase	NOUN
ecletica-510	68	8	in	in	ADP
ecletica-510	68	9	the	the	DET
ecletica-510	68	10	complexes	complex	NOUN
ecletica-510	68	11	cdk	cdk	NOUN
ecletica-510	68	12	:	:	PUNCT
ecletica-510	68	13	inhibitor	inhibitor	NOUN
ecletica-510	68	14	are	be	AUX
ecletica-510	68	15	folded	fold	VERB
ecletica-510	68	16	into	into	ADP
ecletica-510	68	17	the	the	DET
ecletica-510	68	18	typical	typical	ADJ
ecletica-510	68	19	bilobal	bilobal	ADJ
ecletica-510	68	20	structure	structure	NOUN
ecletica-510	68	21	,	,	PUNCT
ecletica-510	68	22	with	with	ADP
ecletica-510	68	23	the	the	DET
ecletica-510	68	24	smaller	small	ADJ
ecletica-510	68	25	n	n	CCONJ
ecletica-510	68	26	-	-	PUNCT
ecletica-510	68	27	terminal	terminal	NOUN
ecletica-510	68	28	lobe	lobe	NOUN
ecletica-510	68	29	consisting	consist	VERB
ecletica-510	68	30	predominantly	predominantly	ADV
ecletica-510	68	31	of	of	ADP
ecletica-510	68	32	b	b	NOUN
ecletica-510	68	33	-	-	PUNCT
ecletica-510	68	34	sheet	sheet	NOUN
ecletica-510	68	35	structure	structure	NOUN
ecletica-510	68	36	and	and	CCONJ
ecletica-510	68	37	the	the	DET
ecletica-510	68	38	larger	large	ADJ
ecletica-510	68	39	c	c	NOUN
ecletica-510	68	40	-	-	PUNCT
ecletica-510	68	41	terminal	terminal	ADJ
ecletica-510	68	42	lobe	lobe	NOUN
ecletica-510	68	43	consisting	consist	VERB
ecletica-510	68	44	primarily	primarily	ADV
ecletica-510	68	45	of	of	ADP
ecletica-510	68	46	α	α	NOUN
ecletica-510	68	47	-	-	PUNCT
ecletica-510	68	48	helices	helix	NOUN
ecletica-510	68	49	.	.	PUNCT
ecletica-510	69	1	the	the	DET
ecletica-510	69	2	n	n	CCONJ
ecletica-510	69	3	-	-	PUNCT
ecletica-510	69	4	terminal	terminal	ADJ
ecletica-510	69	5	lobe	lobe	NOUN
ecletica-510	69	6	of	of	ADP
ecletica-510	69	7	cdk	cdk	PROPN
ecletica-510	69	8	consists	consist	VERB
ecletica-510	69	9	of	of	ADP
ecletica-510	69	10	a	a	DET
ecletica-510	69	11	sheet	sheet	NOUN
ecletica-510	69	12	of	of	ADP
ecletica-510	69	13	five	five	NUM
ecletica-510	69	14	antiparallel	antiparallel	ADJ
ecletica-510	69	15	β	β	NOUN
ecletica-510	69	16	-	-	NOUN
ecletica-510	69	17	strands	strand	NOUN
ecletica-510	69	18	(	(	PUNCT
ecletica-510	69	19	β1	β1	NOUN
ecletica-510	69	20	-	-	PUNCT
ecletica-510	69	21	β5	β5	NOUN
ecletica-510	69	22	)	)	PUNCT
ecletica-510	69	23	and	and	CCONJ
ecletica-510	69	24	a	a	DET
ecletica-510	69	25	single	single	ADJ
ecletica-510	69	26	large	large	ADJ
ecletica-510	69	27	helix	helix	NOUN
ecletica-510	69	28	(	(	PUNCT
ecletica-510	69	29	α1	α1	PROPN
ecletica-510	69	30	)	)	PUNCT
ecletica-510	69	31	.	.	PUNCT
ecletica-510	70	1	the	the	DET
ecletica-510	70	2	c	c	NOUN
ecletica-510	70	3	-	-	PUNCT
ecletica-510	70	4	terminal	terminal	ADJ
ecletica-510	70	5	lobe	lobe	NOUN
ecletica-510	70	6	contains	contain	VERB
ecletica-510	70	7	a	a	DET
ecletica-510	70	8	pseudo-4	pseudo-4	ADV
ecletica-510	70	9	-	-	ADJ
ecletica-510	70	10	helical	helical	ADJ
ecletica-510	70	11	bundle	bundle	NOUN
ecletica-510	70	12	(	(	PUNCT
ecletica-510	70	13	α2,3,4,6	α2,3,4,6	PROPN
ecletica-510	70	14	)	)	PUNCT
ecletica-510	70	15	,	,	PUNCT
ecletica-510	70	16	a	a	DET
ecletica-510	70	17	small	small	ADJ
ecletica-510	70	18	bribbon	bribbon	NOUN
ecletica-510	70	19	(	(	PUNCT
ecletica-510	70	20	β6	β6	PROPN
ecletica-510	70	21	-	-	PUNCT
ecletica-510	70	22	β8	β8	NOUN
ecletica-510	70	23	)	)	PUNCT
ecletica-510	70	24	,	,	PUNCT
ecletica-510	70	25	and	and	CCONJ
ecletica-510	70	26	two	two	NUM
ecletica-510	70	27	additional	additional	ADJ
ecletica-510	70	28	helices	helix	NOUN
ecletica-510	70	29	(	(	PUNCT
ecletica-510	70	30	α5,7	α5,7	NOUN
ecletica-510	70	31	)	)	PUNCT
ecletica-510	70	32	.	.	PUNCT
ecletica-510	71	1	figure	figure	NOUN
ecletica-510	71	2	2	2	NUM
ecletica-510	71	3	shows	show	VERB
ecletica-510	71	4	schematic	schematic	ADJ
ecletica-510	71	5	drawings	drawing	NOUN
ecletica-510	71	6	of	of	ADP
ecletica-510	71	7	the	the	DET
ecletica-510	71	8	complexes	complex	NOUN
ecletica-510	71	9	cdk9	cdk9	NOUN
ecletica-510	71	10	:	:	PUNCT
ecletica-510	71	11	flavopiridol	flavopiridol	PROPN
ecletica-510	71	12	,	,	PUNCT
ecletica-510	71	13	cdk5	cdk5	PROPN
ecletica-510	71	14	:	:	PUNCT
ecletica-510	71	15	roscovitine	roscovitine	NOUN
ecletica-510	71	16	,	,	PUNCT
ecletica-510	71	17	cdk1	cdk1	PROPN
ecletica-510	71	18	:	:	PUNCT
ecletica-510	71	19	flavopiridol	flavopiridol	NOUN
ecletica-510	71	20	and	and	CCONJ
ecletica-510	71	21	cdk1	cdk1	PROPN
ecletica-510	71	22	:	:	PUNCT
ecletica-510	71	23	roscovitine	roscovitine	ADJ
ecletica-510	71	24	.	.	PUNCT
ecletica-510	72	1	the	the	DET
ecletica-510	72	2	flavopiridol	flavopiridol	PROPN
ecletica-510	72	3	and	and	CCONJ
ecletica-510	72	4	roscovitine	roscovitine	NOUN
ecletica-510	72	5	molecules	molecule	NOUN
ecletica-510	72	6	are	be	AUX
ecletica-510	72	7	found	find	VERB
ecletica-510	72	8	in	in	ADP
ecletica-510	72	9	the	the	DET
ecletica-510	72	10	cleft	cleft	NOUN
ecletica-510	72	11	between	between	ADP
ecletica-510	72	12	the	the	DET
ecletica-510	72	13	two	two	NUM
ecletica-510	72	14	lobes	lobe	NOUN
ecletica-510	72	15	.	.	PUNCT
ecletica-510	73	1	the	the	DET
ecletica-510	73	2	core	core	NOUN
ecletica-510	73	3	(	(	PUNCT
ecletica-510	73	4	the	the	DET
ecletica-510	73	5	βsheet	βsheet	NOUN
ecletica-510	73	6	and	and	CCONJ
ecletica-510	73	7	the	the	DET
ecletica-510	73	8	helical	helical	ADJ
ecletica-510	73	9	bundle	bundle	NOUN
ecletica-510	73	10	)	)	PUNCT
ecletica-510	73	11	of	of	ADP
ecletica-510	73	12	the	the	DET
ecletica-510	73	13	cdk9	cdk9	NOUN
ecletica-510	73	14	,	,	PUNCT
ecletica-510	73	15	5	5	NUM
ecletica-510	73	16	and	and	CCONJ
ecletica-510	73	17	1	1	NUM
ecletica-510	73	18	structures	structure	NOUN
ecletica-510	73	19	are	be	AUX
ecletica-510	73	20	very	very	ADV
ecletica-510	73	21	similar	similar	ADJ
ecletica-510	73	22	to	to	ADP
ecletica-510	73	23	that	that	PRON
ecletica-510	73	24	of	of	ADP
ecletica-510	73	25	cdk2	cdk2	PROPN
ecletica-510	73	26	[	[	X
ecletica-510	73	27	18	18	NUM
ecletica-510	73	28	]	]	PUNCT
ecletica-510	73	29	.	.	PUNCT
ecletica-510	74	1	the	the	DET
ecletica-510	74	2	conserved	conserved	ADJ
ecletica-510	74	3	core	core	NOUN
ecletica-510	74	4	consists	consist	VERB
ecletica-510	74	5	of	of	ADP
ecletica-510	74	6	a	a	DET
ecletica-510	74	7	small	small	ADJ
ecletica-510	74	8	lobe	lobe	NOUN
ecletica-510	74	9	associated	associate	VERB
ecletica-510	74	10	primarily	primarily	ADV
ecletica-510	74	11	with	with	ADP
ecletica-510	74	12	atp	atp	NOUN
ecletica-510	74	13	binding	bind	VERB
ecletica-510	74	14	and	and	CCONJ
ecletica-510	74	15	a	a	DET
ecletica-510	74	16	large	large	ADJ
ecletica-510	74	17	lobe	lobe	NOUN
ecletica-510	74	18	associated	associate	VERB
ecletica-510	74	19	with	with	ADP
ecletica-510	74	20	peptide	peptide	NOUN
ecletica-510	74	21	binding	binding	NOUN
ecletica-510	74	22	and	and	CCONJ
ecletica-510	74	23	catalysis	catalysis	NOUN
ecletica-510	74	24	.	.	PUNCT
ecletica-510	75	1	figure	figure	NOUN
ecletica-510	75	2	1	1	NUM
ecletica-510	75	3	:	:	PUNCT
ecletica-510	75	4	sequence	sequence	NOUN
ecletica-510	75	5	alignment	alignment	NOUN
ecletica-510	75	6	of	of	ADP
ecletica-510	75	7	human	human	ADJ
ecletica-510	75	8	cdk2	cdk2	PROPN
ecletica-510	75	9	with	with	ADP
ecletica-510	75	10	cdk9	cdk9	PROPN
ecletica-510	75	11	,	,	PUNCT
ecletica-510	75	12	cdk1	cdk1	PROPN
ecletica-510	75	13	,	,	PUNCT
ecletica-510	75	14	and	and	CCONJ
ecletica-510	75	15	cdk5	cdk5	PROPN
ecletica-510	75	16	.	.	PUNCT
ecletica-510	76	1	there	there	PRON
ecletica-510	76	2	are	be	VERB
ecletica-510	76	3	39.1	39.1	NUM
ecletica-510	76	4	%	%	NOUN
ecletica-510	76	5	of	of	ADP
ecletica-510	76	6	identity	identity	NOUN
ecletica-510	76	7	between	between	ADP
ecletica-510	76	8	cdk2	cdk2	PROPN
ecletica-510	76	9	and	and	CCONJ
ecletica-510	76	10	cdk9	cdk9	PROPN
ecletica-510	76	11	sequences	sequence	NOUN
ecletica-510	76	12	,	,	PUNCT
ecletica-510	76	13	65.1	65.1	NUM
ecletica-510	76	14	%	%	NOUN
ecletica-510	76	15	between	between	ADP
ecletica-510	76	16	cdk2	cdk2	PROPN
ecletica-510	76	17	and	and	CCONJ
ecletica-510	76	18	cdk1	cdk1	PROPN
ecletica-510	76	19	,	,	PUNCT
ecletica-510	76	20	and	and	CCONJ
ecletica-510	76	21	58.3	58.3	NUM
ecletica-510	76	22	%	%	NOUN
ecletica-510	76	23	between	between	ADP
ecletica-510	76	24	cdk2	cdk2	PROPN
ecletica-510	76	25	and	and	CCONJ
ecletica-510	76	26	cdk5	cdk5	PROPN
ecletica-510	76	27	sequences	sequence	NOUN
ecletica-510	76	28	.	.	PUNCT
ecletica-510	77	1	the	the	DET
ecletica-510	77	2	multiple	multiple	ADJ
ecletica-510	77	3	alignment	alignment	NOUN
ecletica-510	77	4	was	be	AUX
ecletica-510	77	5	performed	perform	VERB
ecletica-510	77	6	with	with	ADP
ecletica-510	77	7	the	the	DET
ecletica-510	77	8	program	program	NOUN
ecletica-510	77	9	multalin	multalin	NOUN
ecletica-510	77	10	(	(	PUNCT
ecletica-510	77	11	40	40	NUM
ecletica-510	77	12	)	)	PUNCT
ecletica-510	77	13	.	.	PUNCT
ecletica-510	78	1	ecl	ecl	PROPN
ecletica-510	78	2	.	.	PROPN
ecletica-510	78	3	quím	quím	PROPN
ecletica-510	78	4	.	.	PUNCT
ecletica-510	78	5	,	,	PUNCT
ecletica-510	78	6	são	são	PROPN
ecletica-510	78	7	paulo	paulo	PROPN
ecletica-510	78	8	,	,	PUNCT
ecletica-510	78	9	28(1	28(1	NOUN
ecletica-510	78	10	):	):	PUNCT
ecletica-510	78	11	45	45	NUM
ecletica-510	78	12	-	-	SYM
ecletica-510	78	13	53	53	NUM
ecletica-510	78	14	,	,	PUNCT
ecletica-510	78	15	2003	2003	NUM
ecletica-510	78	16	48	48	NUM
ecletica-510	78	17	inhibitors	inhibitor	NOUN
ecletica-510	78	18	have	have	VERB
ecletica-510	78	19	pairs	pair	NOUN
ecletica-510	78	20	of	of	ADP
ecletica-510	78	21	hydrogen	hydrogen	NOUN
ecletica-510	78	22	bond	bond	NOUN
ecletica-510	78	23	partners	partner	NOUN
ecletica-510	78	24	that	that	PRON
ecletica-510	78	25	show	show	VERB
ecletica-510	78	26	complementarity	complementarity	NOUN
ecletica-510	78	27	to	to	ADP
ecletica-510	78	28	the	the	DET
ecletica-510	78	29	molecular	molecular	ADJ
ecletica-510	78	30	fork	fork	NOUN
ecletica-510	78	31	on	on	ADP
ecletica-510	78	32	cdk2	cdk2	PROPN
ecletica-510	78	33	,	,	PUNCT
ecletica-510	78	34	most	most	ADJ
ecletica-510	78	35	of	of	ADP
ecletica-510	78	36	them	they	PRON
ecletica-510	78	37	involving	involve	VERB
ecletica-510	78	38	at	at	ADV
ecletica-510	78	39	least	least	ADV
ecletica-510	78	40	two	two	NUM
ecletica-510	78	41	hydrogen	hydrogen	NOUN
ecletica-510	78	42	bonds	bond	NOUN
ecletica-510	78	43	with	with	ADP
ecletica-510	78	44	the	the	DET
ecletica-510	78	45	molecular	molecular	ADJ
ecletica-510	78	46	fork	fork	NOUN
ecletica-510	78	47	.	.	PUNCT
ecletica-510	79	1	the	the	DET
ecletica-510	79	2	relative	relative	ADJ
ecletica-510	79	3	orientation	orientation	NOUN
ecletica-510	79	4	of	of	ADP
ecletica-510	79	5	the	the	DET
ecletica-510	79	6	inhibitor	inhibitor	NOUN
ecletica-510	79	7	in	in	ADP
ecletica-510	79	8	the	the	DET
ecletica-510	79	9	binding	bind	VERB
ecletica-510	79	10	pocket	pocket	NOUN
ecletica-510	79	11	of	of	ADP
ecletica-510	79	12	cdk2	cdk2	PROPN
ecletica-510	79	13	locates	locate	VERB
ecletica-510	79	14	one	one	NUM
ecletica-510	79	15	hydrogen	hydrogen	NOUN
ecletica-510	79	16	bond	bond	NOUN
ecletica-510	79	17	donor	donor	NOUN
ecletica-510	79	18	close	close	ADV
ecletica-510	79	19	to	to	ADP
ecletica-510	79	20	c	c	NOUN
ecletica-510	79	21	=	=	X
ecletica-510	79	22	o	o	X
ecletica-510	79	23	in	in	ADP
ecletica-510	79	24	glu81	glu81	PROPN
ecletica-510	79	25	and/or	and/or	CCONJ
ecletica-510	79	26	leu83	leu83	VERB
ecletica-510	79	27	,	,	PUNCT
ecletica-510	79	28	and	and	CCONJ
ecletica-510	79	29	an	an	DET
ecletica-510	79	30	acceptor	acceptor	NOUN
ecletica-510	79	31	close	close	ADV
ecletica-510	79	32	to	to	ADP
ecletica-510	79	33	n	n	NOUN
ecletica-510	79	34	-	-	PUNCT
ecletica-510	79	35	h	h	NOUN
ecletica-510	79	36	in	in	ADP
ecletica-510	79	37	leu83	leu83	PROPN
ecletica-510	79	38	.	.	PUNCT
ecletica-510	80	1	such	such	ADJ
ecletica-510	80	2	simple	simple	ADJ
ecletica-510	80	3	paradigm	paradigm	NOUN
ecletica-510	80	4	is	be	AUX
ecletica-510	80	5	conserved	conserve	VERB
ecletica-510	80	6	in	in	ADP
ecletica-510	80	7	all	all	DET
ecletica-510	80	8	cdk2	cdk2	NOUN
ecletica-510	80	9	:	:	PUNCT
ecletica-510	80	10	inhibitor	inhibitor	NOUN
ecletica-510	80	11	complex	complex	NOUN
ecletica-510	80	12	structures	structure	NOUN
ecletica-510	80	13	solved	solve	VERB
ecletica-510	80	14	so	so	ADV
ecletica-510	80	15	far	far	ADV
ecletica-510	80	16	.	.	PUNCT
ecletica-510	81	1	in	in	ADP
ecletica-510	81	2	all	all	DET
ecletica-510	81	3	binary	binary	ADJ
ecletica-510	81	4	models	model	NOUN
ecletica-510	81	5	this	this	DET
ecletica-510	81	6	molecular	molecular	ADJ
ecletica-510	81	7	fork	fork	NOUN
ecletica-510	81	8	is	be	AUX
ecletica-510	81	9	also	also	ADV
ecletica-510	81	10	conserved	conserve	VERB
ecletica-510	81	11	.	.	PUNCT
ecletica-510	82	1	table	table	NOUN
ecletica-510	82	2	1	1	NUM
ecletica-510	82	3	:	:	PUNCT
ecletica-510	82	4	hydrogen	hydrogen	NOUN
ecletica-510	82	5	bonds	bond	NOUN
ecletica-510	82	6	between	between	ADP
ecletica-510	82	7	the	the	DET
ecletica-510	82	8	molecular	molecular	ADJ
ecletica-510	82	9	fork	fork	NOUN
ecletica-510	82	10	of	of	ADP
ecletica-510	82	11	cdk2	cdk2	PROPN
ecletica-510	82	12	and	and	CCONJ
ecletica-510	82	13	inhibitor	inhibitor	NOUN
ecletica-510	82	14	.	.	PUNCT
ecletica-510	83	1	interactions	interaction	NOUN
ecletica-510	83	2	of	of	ADP
ecletica-510	83	3	flavopiridol	flavopiridol	NOUN
ecletica-510	83	4	with	with	ADP
ecletica-510	83	5	cdk9	cdk9	PROPN
ecletica-510	83	6	the	the	DET
ecletica-510	83	7	specificity	specificity	NOUN
ecletica-510	83	8	and	and	CCONJ
ecletica-510	83	9	affinity	affinity	NOUN
ecletica-510	83	10	between	between	ADP
ecletica-510	83	11	an	an	DET
ecletica-510	83	12	enzyme	enzyme	NOUN
ecletica-510	83	13	and	and	CCONJ
ecletica-510	83	14	its	its	PRON
ecletica-510	83	15	inhibitor	inhibitor	NOUN
ecletica-510	83	16	depend	depend	VERB
ecletica-510	83	17	on	on	ADP
ecletica-510	83	18	hydrogen	hydrogen	NOUN
ecletica-510	83	19	bonds	bond	NOUN
ecletica-510	83	20	and	and	CCONJ
ecletica-510	83	21	ionic	ionic	ADJ
ecletica-510	83	22	interactions	interaction	NOUN
ecletica-510	83	23	,	,	PUNCT
ecletica-510	83	24	as	as	ADV
ecletica-510	83	25	well	well	ADV
ecletica-510	83	26	as	as	ADP
ecletica-510	83	27	on	on	ADP
ecletica-510	83	28	shape	shape	NOUN
ecletica-510	83	29	complementarity	complementarity	NOUN
ecletica-510	83	30	of	of	ADP
ecletica-510	83	31	the	the	DET
ecletica-510	83	32	contact	contact	NOUN
ecletica-510	83	33	surfaces	surface	NOUN
ecletica-510	83	34	of	of	ADP
ecletica-510	83	35	both	both	DET
ecletica-510	83	36	partners	partner	NOUN
ecletica-510	83	37	[	[	X
ecletica-510	83	38	16	16	NUM
ecletica-510	83	39	,	,	PUNCT
ecletica-510	83	40	7	7	NUM
ecletica-510	83	41	,	,	PUNCT
ecletica-510	83	42	13	13	NUM
ecletica-510	83	43	]	]	PUNCT
ecletica-510	83	44	.	.	PUNCT
ecletica-510	84	1	it	it	PRON
ecletica-510	84	2	was	be	AUX
ecletica-510	84	3	observed	observe	VERB
ecletica-510	84	4	a	a	DET
ecletica-510	84	5	total	total	NOUN
ecletica-510	84	6	of	of	ADP
ecletica-510	84	7	three	three	NUM
ecletica-510	84	8	hydrogen	hydrogen	NOUN
ecletica-510	84	9	bonds	bond	NOUN
ecletica-510	84	10	between	between	ADP
ecletica-510	84	11	cdk9	cdk9	PROPN
ecletica-510	84	12	and	and	CCONJ
ecletica-510	84	13	flavopiridol	flavopiridol	NOUN
ecletica-510	84	14	,	,	PUNCT
ecletica-510	84	15	in	in	ADP
ecletica-510	84	16	binary	binary	PROPN
ecletica-510	84	17	model	model	NOUN
ecletica-510	84	18	,	,	PUNCT
ecletica-510	84	19	involving	involve	VERB
ecletica-510	84	20	the	the	DET
ecletica-510	84	21	residues	residue	NOUN
ecletica-510	84	22	lys	lys	NOUN
ecletica-510	84	23	33	33	NUM
ecletica-510	84	24	,	,	PUNCT
ecletica-510	84	25	asp	asp	PROPN
ecletica-510	84	26	89	89	NUM
ecletica-510	84	27	,	,	PUNCT
ecletica-510	84	28	cys	cys	PROPN
ecletica-510	84	29	91	91	NUM
ecletica-510	84	30	.	.	PUNCT
ecletica-510	85	1	for	for	ADP
ecletica-510	85	2	the	the	DET
ecletica-510	85	3	cdk2	cdk2	PROPN
ecletica-510	85	4	:	:	PUNCT
ecletica-510	85	5	flavopiridol	flavopiridol	PROPN
ecletica-510	85	6	model	model	VERB
ecletica-510	85	7	four	four	NUM
ecletica-510	85	8	hydrogen	hydrogen	NOUN
ecletica-510	85	9	bonds	bond	NOUN
ecletica-510	85	10	involving	involve	VERB
ecletica-510	85	11	the	the	DET
ecletica-510	85	12	residues	residue	NOUN
ecletica-510	85	13	lys33	lys33	NOUN
ecletica-510	85	14	,	,	PUNCT
ecletica-510	85	15	glu81	glu81	PROPN
ecletica-510	85	16	,	,	PUNCT
ecletica-510	85	17	leu83	leu83	NOUN
ecletica-510	85	18	,	,	PUNCT
ecletica-510	85	19	and	and	CCONJ
ecletica-510	85	20	asp152	asp152	PROPN
ecletica-510	85	21	were	be	AUX
ecletica-510	85	22	observed	observe	VERB
ecletica-510	85	23	.	.	PUNCT
ecletica-510	86	1	table	table	NOUN
ecletica-510	86	2	2	2	NUM
ecletica-510	86	3	and	and	CCONJ
ecletica-510	86	4	3	3	NUM
ecletica-510	86	5	show	show	VERB
ecletica-510	86	6	the	the	DET
ecletica-510	86	7	intermolecular	intermolecular	ADJ
ecletica-510	86	8	hydrogen	hydrogen	NOUN
ecletica-510	86	9	bonds	bond	NOUN
ecletica-510	86	10	for	for	ADP
ecletica-510	86	11	both	both	DET
ecletica-510	86	12	structures	structure	NOUN
ecletica-510	86	13	.	.	PUNCT
ecletica-510	87	1	as	as	SCONJ
ecletica-510	87	2	observed	observe	VERB
ecletica-510	87	3	for	for	ADP
ecletica-510	87	4	the	the	DET
ecletica-510	87	5	crystallographic	crystallographic	ADJ
ecletica-510	87	6	structure	structure	NOUN
ecletica-510	87	7	of	of	ADP
ecletica-510	87	8	deschloroflavopiridol	deschloroflavopiridol	NOUN
ecletica-510	87	9	bound	bind	VERB
ecletica-510	87	10	to	to	ADP
ecletica-510	87	11	cdk2	cdk2	PROPN
ecletica-510	87	12	[	[	X
ecletica-510	87	13	17	17	NUM
ecletica-510	87	14	]	]	PUNCT
ecletica-510	87	15	,	,	PUNCT
ecletica-510	87	16	the	the	DET
ecletica-510	87	17	region	region	NOUN
ecletica-510	87	18	of	of	ADP
ecletica-510	87	19	cdk9	cdk9	PROPN
ecletica-510	87	20	occupied	occupy	VERB
ecletica-510	87	21	by	by	ADP
ecletica-510	87	22	the	the	DET
ecletica-510	87	23	chlorophenyl	chlorophenyl	PROPN
ecletica-510	87	24	ring	ring	NOUN
ecletica-510	87	25	of	of	ADP
ecletica-510	87	26	flavopiridol	flavopiridol	NOUN
ecletica-510	87	27	is	be	AUX
ecletica-510	87	28	pointing	point	VERB
ecletica-510	87	29	away	away	ADV
ecletica-510	87	30	from	from	ADP
ecletica-510	87	31	the	the	DET
ecletica-510	87	32	atp	atp	NOUN
ecletica-510	87	33	-	-	PUNCT
ecletica-510	87	34	binding	bind	VERB
ecletica-510	87	35	pocket	pocket	NOUN
ecletica-510	87	36	,	,	PUNCT
ecletica-510	87	37	and	and	CCONJ
ecletica-510	87	38	partially	partially	ADV
ecletica-510	87	39	exposed	expose	VERB
ecletica-510	87	40	to	to	ADP
ecletica-510	87	41	solvent	solvent	NOUN
ecletica-510	87	42	.	.	PUNCT
ecletica-510	88	1	in	in	ADP
ecletica-510	88	2	cdk9	cdk9	PROPN
ecletica-510	88	3	,	,	PUNCT
ecletica-510	88	4	the	the	DET
ecletica-510	88	5	residues	residue	NOUN
ecletica-510	88	6	93	93	NUM
ecletica-510	88	7	to	to	PART
ecletica-510	88	8	95	95	NUM
ecletica-510	88	9	present	present	NOUN
ecletica-510	88	10	a	a	DET
ecletica-510	88	11	β	β	NOUN
ecletica-510	88	12	-	-	NOUN
ecletica-510	88	13	sheet	sheet	NOUN
ecletica-510	88	14	,	,	PUNCT
ecletica-510	88	15	while	while	SCONJ
ecletica-510	88	16	in	in	ADP
ecletica-510	88	17	cdk2	cdk2	PROPN
ecletica-510	88	18	this	this	DET
ecletica-510	88	19	region	region	NOUN
ecletica-510	88	20	(	(	PUNCT
ecletica-510	88	21	residues	residue	NOUN
ecletica-510	88	22	85	85	NUM
ecletica-510	88	23	to	to	PART
ecletica-510	88	24	87	87	NUM
ecletica-510	88	25	)	)	PUNCT
ecletica-510	88	26	is	be	AUX
ecletica-510	88	27	in	in	ADP
ecletica-510	88	28	random	random	ADJ
ecletica-510	88	29	coil	coil	NOUN
ecletica-510	88	30	.	.	PUNCT
ecletica-510	89	1	most	most	ADJ
ecletica-510	89	2	of	of	ADP
ecletica-510	89	3	the	the	DET
ecletica-510	89	4	residues	residue	NOUN
ecletica-510	89	5	conserved	conserve	VERB
ecletica-510	89	6	throughout	throughout	ADP
ecletica-510	89	7	the	the	DET
ecletica-510	89	8	protein	protein	NOUN
ecletica-510	89	9	kinase	kinase	PROPN
ecletica-510	89	10	family	family	NOUN
ecletica-510	89	11	cluster	cluster	NOUN
ecletica-510	89	12	around	around	ADP
ecletica-510	89	13	the	the	DET
ecletica-510	89	14	active	active	ADJ
ecletica-510	89	15	cleft	cleft	NOUN
ecletica-510	89	16	[	[	X
ecletica-510	89	17	41	41	NUM
ecletica-510	89	18	]	]	PUNCT
ecletica-510	89	19	.	.	PUNCT
ecletica-510	90	1	figure	figure	NOUN
ecletica-510	90	2	2	2	NUM
ecletica-510	90	3	:	:	PUNCT
ecletica-510	90	4	ribbon	ribbon	NOUN
ecletica-510	90	5	diagram	diagram	NOUN
ecletica-510	90	6	of	of	ADP
ecletica-510	90	7	the	the	DET
ecletica-510	90	8	complex	complex	NOUN
ecletica-510	91	1	c	c	PROPN
ecletica-510	91	2	d	d	X
ecletica-510	91	3	k	k	PROPN
ecletica-510	91	4	9	9	NUM
ecletica-510	91	5	:	:	PUNCT
ecletica-510	91	6	f	f	X
ecletica-510	91	7	l	l	NOUN
ecletica-510	92	1	a	a	DET
ecletica-510	92	2	v	v	NOUN
ecletica-510	92	3	o	o	X
ecletica-510	93	1	p	p	X
ecletica-510	94	1	i	i	PRON
ecletica-510	95	1	r	r	VERB
ecletica-510	96	1	i	i	NOUN
ecletica-510	97	1	d	d	NOUN
ecletica-510	97	2	o	o	X
ecletica-510	97	3	l	l	NOUN
ecletica-510	97	4	(	(	PUNCT
ecletica-510	97	5	a	a	NOUN
ecletica-510	97	6	)	)	PUNCT
ecletica-510	97	7	,	,	PUNCT
ecletica-510	98	1	c	c	PROPN
ecletica-510	98	2	d	d	X
ecletica-510	98	3	k	k	PROPN
ecletica-510	98	4	5	5	NUM
ecletica-510	98	5	:	:	PUNCT
ecletica-510	98	6	r	r	NOUN
ecletica-510	98	7	o	o	NOUN
ecletica-510	98	8	s	s	X
ecletica-510	98	9	c	c	X
ecletica-510	98	10	o	o	NOUN
ecletica-510	98	11	v	v	INTJ
ecletica-510	99	1	i	i	PRON
ecletica-510	99	2	t	t	X
ecletica-510	99	3	i	i	PRON
ecletica-510	99	4	n	n	NUM
ecletica-510	99	5	e	e	X
ecletica-510	99	6	(	(	PUNCT
ecletica-510	99	7	b	b	PROPN
ecletica-510	99	8	)	)	PUNCT
ecletica-510	99	9	,	,	PUNCT
ecletica-510	99	10	cdk1	cdk1	PROPN
ecletica-510	99	11	:	:	PUNCT
ecletica-510	99	12	flavopiridol	flavopiridol	NOUN
ecletica-510	99	13	(	(	PUNCT
ecletica-510	99	14	c	c	NOUN
ecletica-510	99	15	)	)	PUNCT
ecletica-510	99	16	,	,	PUNCT
ecletica-510	99	17	and	and	CCONJ
ecletica-510	99	18	cdk1	cdk1	PROPN
ecletica-510	99	19	:	:	PUNCT
ecletica-510	99	20	roscovitine	roscovitine	NOUN
ecletica-510	99	21	(	(	PUNCT
ecletica-510	99	22	d	d	X
ecletica-510	99	23	)	)	PUNCT
ecletica-510	99	24	generated	generate	VERB
ecletica-510	99	25	by	by	ADP
ecletica-510	99	26	molscript	molscript	NOUN
ecletica-510	99	27	(	(	PUNCT
ecletica-510	99	28	41	41	NUM
ecletica-510	99	29	)	)	PUNCT
ecletica-510	99	30	.	.	PUNCT
ecletica-510	100	1	molecular	molecular	ADJ
ecletica-510	100	2	fork	fork	NOUN
ecletica-510	100	3	it	it	PRON
ecletica-510	100	4	has	have	AUX
ecletica-510	100	5	been	be	AUX
ecletica-510	100	6	observed	observe	VERB
ecletica-510	100	7	in	in	ADP
ecletica-510	100	8	several	several	ADJ
ecletica-510	100	9	cdk2	cdk2	NOUN
ecletica-510	100	10	:	:	PUNCT
ecletica-510	100	11	inhibitor	inhibitor	NOUN
ecletica-510	100	12	structures	structure	VERB
ecletica-510	100	13	the	the	DET
ecletica-510	100	14	participation	participation	NOUN
ecletica-510	100	15	of	of	ADP
ecletica-510	100	16	a	a	DET
ecletica-510	100	17	molecular	molecular	ADJ
ecletica-510	100	18	fork	fork	NOUN
ecletica-510	100	19	,	,	PUNCT
ecletica-510	100	20	composed	compose	VERB
ecletica-510	100	21	by	by	ADP
ecletica-510	100	22	a	a	DET
ecletica-510	100	23	c	c	PROPN
ecletica-510	100	24	=	=	NOUN
ecletica-510	100	25	o	o	NOUN
ecletica-510	100	26	group	group	NOUN
ecletica-510	100	27	of	of	ADP
ecletica-510	100	28	glu81	glu81	PROPN
ecletica-510	100	29	and	and	CCONJ
ecletica-510	100	30	the	the	DET
ecletica-510	100	31	n	n	NOUN
ecletica-510	100	32	-	-	PUNCT
ecletica-510	100	33	h	h	NOUN
ecletica-510	100	34	and	and	CCONJ
ecletica-510	100	35	c	c	NOUN
ecletica-510	100	36	=	=	NOUN
ecletica-510	100	37	o	o	PROPN
ecletica-510	100	38	group	group	NOUN
ecletica-510	100	39	of	of	ADP
ecletica-510	100	40	leu83	leu83	PROPN
ecletica-510	100	41	,	,	PUNCT
ecletica-510	100	42	in	in	ADP
ecletica-510	100	43	hydrogen	hydrogen	NOUN
ecletica-510	100	44	bonds	bond	NOUN
ecletica-510	100	45	between	between	ADP
ecletica-510	100	46	cdk2	cdk2	PROPN
ecletica-510	100	47	and	and	CCONJ
ecletica-510	100	48	the	the	DET
ecletica-510	100	49	inhibitor	inhibitor	NOUN
ecletica-510	100	50	.	.	PUNCT
ecletica-510	101	1	this	this	DET
ecletica-510	101	2	molecular	molecular	ADJ
ecletica-510	101	3	fork	fork	NOUN
ecletica-510	101	4	,	,	PUNCT
ecletica-510	101	5	composed	compose	VERB
ecletica-510	101	6	of	of	ADP
ecletica-510	101	7	two	two	NUM
ecletica-510	101	8	hydrogen	hydrogen	NOUN
ecletica-510	101	9	bond	bond	NOUN
ecletica-510	101	10	acceptors	acceptor	NOUN
ecletica-510	101	11	(	(	PUNCT
ecletica-510	101	12	c	c	NOUN
ecletica-510	101	13	=	=	NOUN
ecletica-510	101	14	o	o	NOUN
ecletica-510	101	15	)	)	PUNCT
ecletica-510	101	16	and	and	CCONJ
ecletica-510	101	17	one	one	NUM
ecletica-510	101	18	hydrogen	hydrogen	NOUN
ecletica-510	101	19	bond	bond	NOUN
ecletica-510	101	20	donor	donor	NOUN
ecletica-510	101	21	(	(	PUNCT
ecletica-510	101	22	n	n	CCONJ
ecletica-510	101	23	-	-	PUNCT
ecletica-510	101	24	h	h	NOUN
ecletica-510	101	25	)	)	PUNCT
ecletica-510	101	26	,	,	PUNCT
ecletica-510	101	27	allows	allow	VERB
ecletica-510	101	28	a	a	DET
ecletica-510	101	29	wide	wide	ADJ
ecletica-510	101	30	range	range	NOUN
ecletica-510	101	31	of	of	ADP
ecletica-510	101	32	different	different	ADJ
ecletica-510	101	33	orientations	orientation	NOUN
ecletica-510	101	34	to	to	PART
ecletica-510	101	35	dock	dock	VERB
ecletica-510	101	36	on	on	ADP
ecletica-510	101	37	to	to	ADP
ecletica-510	101	38	the	the	DET
ecletica-510	101	39	atp	atp	NOUN
ecletica-510	101	40	binding	bind	VERB
ecletica-510	101	41	pocket	pocket	NOUN
ecletica-510	101	42	,	,	PUNCT
ecletica-510	101	43	such	such	ADJ
ecletica-510	101	44	as	as	ADP
ecletica-510	101	45	:	:	PUNCT
ecletica-510	101	46	olomoucine	olomoucine	PROPN
ecletica-510	101	47	,	,	PUNCT
ecletica-510	101	48	isopentenyladenine	isopentenyladenine	NOUN
ecletica-510	101	49	,	,	PUNCT
ecletica-510	101	50	and	and	CCONJ
ecletica-510	101	51	roscovitine	roscovitine	VERB
ecletica-510	102	1	[	[	X
ecletica-510	102	2	39	39	NUM
ecletica-510	102	3	,	,	PUNCT
ecletica-510	102	4	16	16	NUM
ecletica-510	102	5	]	]	PUNCT
ecletica-510	102	6	,	,	PUNCT
ecletica-510	102	7	staurosporine	staurosporine	VERB
ecletica-510	103	1	[	[	X
ecletica-510	103	2	27	27	NUM
ecletica-510	103	3	]	]	PUNCT
ecletica-510	103	4	,	,	PUNCT
ecletica-510	103	5	purvalanols	purvalanol	NOUN
ecletica-510	103	6	[	[	X
ecletica-510	103	7	21	21	NUM
ecletica-510	103	8	]	]	PUNCT
ecletica-510	103	9	,	,	PUNCT
ecletica-510	103	10	indirubins	indirubin	VERB
ecletica-510	103	11	[	[	X
ecletica-510	103	12	22	22	NUM
ecletica-510	103	13	]	]	PUNCT
ecletica-510	103	14	,	,	PUNCT
ecletica-510	103	15	hymenialdisine	hymenialdisine	VERB
ecletica-510	104	1	[	[	X
ecletica-510	104	2	29	29	NUM
ecletica-510	104	3	]	]	PUNCT
ecletica-510	104	4	,	,	PUNCT
ecletica-510	104	5	nu2058	nu2058	X
ecletica-510	105	1	[	[	X
ecletica-510	105	2	2	2	NUM
ecletica-510	105	3	]	]	PUNCT
ecletica-510	105	4	.	.	PUNCT
ecletica-510	106	1	table	table	NOUN
ecletica-510	106	2	1	1	NUM
ecletica-510	106	3	shows	show	VERB
ecletica-510	106	4	the	the	DET
ecletica-510	106	5	hydrogen	hydrogen	NOUN
ecletica-510	106	6	bond	bond	NOUN
ecletica-510	106	7	distances	distance	NOUN
ecletica-510	106	8	between	between	ADP
ecletica-510	106	9	the	the	DET
ecletica-510	106	10	molecular	molecular	ADJ
ecletica-510	106	11	fork	fork	NOUN
ecletica-510	106	12	of	of	ADP
ecletica-510	106	13	cdk2	cdk2	PROPN
ecletica-510	106	14	and	and	CCONJ
ecletica-510	106	15	different	different	ADJ
ecletica-510	106	16	inhibitors	inhibitor	NOUN
ecletica-510	106	17	.	.	PUNCT
ecletica-510	107	1	all	all	DET
ecletica-510	107	2	these	these	DET
ecletica-510	107	3	ecl	ecl	PROPN
ecletica-510	107	4	.	.	PROPN
ecletica-510	107	5	quím	quím	PROPN
ecletica-510	107	6	.	.	PUNCT
ecletica-510	107	7	,	,	PUNCT
ecletica-510	107	8	são	são	PROPN
ecletica-510	107	9	paulo	paulo	PROPN
ecletica-510	107	10	,	,	PUNCT
ecletica-510	107	11	28(1	28(1	NOUN
ecletica-510	107	12	):	):	PUNCT
ecletica-510	107	13	45	45	NUM
ecletica-510	107	14	-	-	SYM
ecletica-510	107	15	53	53	NUM
ecletica-510	107	16	,	,	PUNCT
ecletica-510	107	17	2003	2003	NUM
ecletica-510	107	18	49	49	NUM
ecletica-510	107	19	table	table	NOUN
ecletica-510	107	20	2	2	NUM
ecletica-510	107	21	:	:	PUNCT
ecletica-510	107	22	hydrogen	hydrogen	NOUN
ecletica-510	107	23	bonds	bond	NOUN
ecletica-510	107	24	between	between	ADP
ecletica-510	107	25	cdk9	cdk9	PROPN
ecletica-510	107	26	:	:	PUNCT
ecletica-510	107	27	flavopiridol	flavopiridol	PROPN
ecletica-510	107	28	.	.	PUNCT
ecletica-510	108	1	superposition	superposition	NOUN
ecletica-510	108	2	of	of	ADP
ecletica-510	108	3	the	the	DET
ecletica-510	108	4	complexes	complex	NOUN
ecletica-510	108	5	of	of	ADP
ecletica-510	108	6	flavopiridol	flavopiridol	NOUN
ecletica-510	108	7	with	with	ADP
ecletica-510	108	8	cdk2	cdk2	PROPN
ecletica-510	108	9	and	and	CCONJ
ecletica-510	108	10	cdk9	cdk9	PROPN
ecletica-510	108	11	is	be	AUX
ecletica-510	108	12	shown	show	VERB
ecletica-510	108	13	in	in	ADP
ecletica-510	108	14	figure	figure	NOUN
ecletica-510	108	15	3a	3a	NUM
ecletica-510	108	16	.	.	PUNCT
ecletica-510	109	1	the	the	DET
ecletica-510	109	2	benzopyran	benzopyran	NOUN
ecletica-510	109	3	ring	ring	NOUN
ecletica-510	109	4	of	of	ADP
ecletica-510	109	5	flavopiridol	flavopiridol	PROPN
ecletica-510	109	6	occupies	occupy	VERB
ecletica-510	109	7	the	the	DET
ecletica-510	109	8	same	same	ADJ
ecletica-510	109	9	region	region	NOUN
ecletica-510	109	10	in	in	ADP
ecletica-510	109	11	both	both	DET
ecletica-510	109	12	complexes	complex	NOUN
ecletica-510	109	13	.	.	PUNCT
ecletica-510	110	1	this	this	DET
ecletica-510	110	2	table	table	NOUN
ecletica-510	110	3	3	3	NUM
ecletica-510	110	4	:	:	PUNCT
ecletica-510	110	5	hydrogen	hydrogen	NOUN
ecletica-510	110	6	bonds	bond	NOUN
ecletica-510	110	7	between	between	ADP
ecletica-510	110	8	cdk2	cdk2	PROPN
ecletica-510	110	9	:	:	PUNCT
ecletica-510	110	10	flavopiridol	flavopiridol	PROPN
ecletica-510	110	11	.	.	PUNCT
ecletica-510	111	1	figure	figure	VERB
ecletica-510	111	2	3	3	NUM
ecletica-510	111	3	:	:	PUNCT
ecletica-510	111	4	(	(	PUNCT
ecletica-510	111	5	a	a	X
ecletica-510	111	6	)	)	PUNCT
ecletica-510	111	7	superimposed	superimpose	VERB
ecletica-510	111	8	binding	bind	VERB
ecletica-510	111	9	pockets	pocket	NOUN
ecletica-510	111	10	of	of	ADP
ecletica-510	111	11	cdk9	cdk9	NOUN
ecletica-510	111	12	:	:	PUNCT
ecletica-510	111	13	flavopiridol	flavopiridol	NOUN
ecletica-510	111	14	complex	complex	ADJ
ecletica-510	111	15	(	(	PUNCT
ecletica-510	111	16	thick	thick	ADJ
ecletica-510	111	17	line	line	NOUN
ecletica-510	111	18	)	)	PUNCT
ecletica-510	111	19	and	and	CCONJ
ecletica-510	111	20	cdk2	cdk2	PROPN
ecletica-510	111	21	:	:	PUNCT
ecletica-510	112	1	flavopiridol	flavopiridol	NOUN
ecletica-510	112	2	complex	complex	ADJ
ecletica-510	112	3	(	(	PUNCT
ecletica-510	112	4	thin	thin	ADJ
ecletica-510	112	5	line	line	NOUN
ecletica-510	112	6	)	)	PUNCT
ecletica-510	112	7	.	.	PUNCT
ecletica-510	113	1	(	(	PUNCT
ecletica-510	113	2	rmsd	rmsd	NOUN
ecletica-510	113	3	value	value	NOUN
ecletica-510	113	4	for	for	ADP
ecletica-510	113	5	c	c	NOUN
ecletica-510	113	6	:	:	PUNCT
ecletica-510	113	7	0.169å	0.169å	NUM
ecletica-510	113	8	)	)	PUNCT
ecletica-510	113	9	(	(	PUNCT
ecletica-510	113	10	b	b	X
ecletica-510	113	11	)	)	PUNCT
ecletica-510	113	12	superimposed	superimpose	VERB
ecletica-510	113	13	binding	bind	VERB
ecletica-510	113	14	pockets	pocket	NOUN
ecletica-510	113	15	of	of	ADP
ecletica-510	113	16	cdk9	cdk9	NOUN
ecletica-510	113	17	:	:	PUNCT
ecletica-510	113	18	flavopiridol	flavopiridol	NOUN
ecletica-510	113	19	complex	complex	ADJ
ecletica-510	113	20	(	(	PUNCT
ecletica-510	113	21	thick	thick	ADJ
ecletica-510	113	22	line	line	NOUN
ecletica-510	113	23	)	)	PUNCT
ecletica-510	113	24	and	and	CCONJ
ecletica-510	113	25	cdk2	cdk2	PROPN
ecletica-510	113	26	:	:	PUNCT
ecletica-510	113	27	atp	atp	PROPN
ecletica-510	113	28	complex	complex	NOUN
ecletica-510	113	29	(	(	PUNCT
ecletica-510	113	30	thin	thin	ADJ
ecletica-510	113	31	line	line	NOUN
ecletica-510	113	32	)	)	PUNCT
ecletica-510	113	33	.	.	PUNCT
ecletica-510	114	1	(	(	PUNCT
ecletica-510	114	2	rmsd	rmsd	NOUN
ecletica-510	114	3	value	value	NOUN
ecletica-510	114	4	for	for	ADP
ecletica-510	114	5	c	c	NOUN
ecletica-510	114	6	:	:	PUNCT
ecletica-510	114	7	0.465å	0.465å	NUM
ecletica-510	114	8	)	)	PUNCT
ecletica-510	114	9	.	.	PUNCT
ecletica-510	115	1	ecl	ecl	PROPN
ecletica-510	115	2	.	.	PROPN
ecletica-510	115	3	quím	quím	PROPN
ecletica-510	115	4	.	.	PUNCT
ecletica-510	115	5	,	,	PUNCT
ecletica-510	115	6	são	são	PROPN
ecletica-510	115	7	paulo	paulo	PROPN
ecletica-510	115	8	,	,	PUNCT
ecletica-510	115	9	28(1	28(1	NOUN
ecletica-510	115	10	):	):	PUNCT
ecletica-510	115	11	45	45	NUM
ecletica-510	115	12	-	-	SYM
ecletica-510	115	13	53	53	NUM
ecletica-510	115	14	,	,	PUNCT
ecletica-510	115	15	2003	2003	NUM
ecletica-510	115	16	region	region	NOUN
ecletica-510	115	17	is	be	AUX
ecletica-510	115	18	the	the	DET
ecletica-510	115	19	same	same	ADJ
ecletica-510	115	20	occupied	occupy	VERB
ecletica-510	115	21	by	by	ADP
ecletica-510	115	22	the	the	DET
ecletica-510	115	23	purine	purine	NOUN
ecletica-510	115	24	ring	ring	NOUN
ecletica-510	115	25	of	of	ADP
ecletica-510	115	26	atp	atp	PROPN
ecletica-510	115	27	in	in	ADP
ecletica-510	115	28	the	the	DET
ecletica-510	115	29	cdk2	cdk2	PROPN
ecletica-510	115	30	:	:	PUNCT
ecletica-510	115	31	atp	atp	PROPN
ecletica-510	115	32	complex	complex	NOUN
ecletica-510	116	1	[	[	X
ecletica-510	116	2	23	23	NUM
ecletica-510	116	3	]	]	PUNCT
ecletica-510	116	4	.	.	PUNCT
ecletica-510	117	1	superposition	superposition	NOUN
ecletica-510	117	2	of	of	ADP
ecletica-510	117	3	the	the	DET
ecletica-510	117	4	cdk2	cdk2	PROPN
ecletica-510	117	5	:	:	PUNCT
ecletica-510	117	6	atp	atp	NOUN
ecletica-510	117	7	onto	onto	ADP
ecletica-510	117	8	cdk9	cdk9	PROPN
ecletica-510	117	9	:	:	PUNCT
ecletica-510	117	10	flavopiridol	flavopiridol	ADJ
ecletica-510	117	11	structure	structure	NOUN
ecletica-510	117	12	indicates	indicate	VERB
ecletica-510	117	13	that	that	SCONJ
ecletica-510	117	14	the	the	DET
ecletica-510	117	15	two	two	NUM
ecletica-510	117	16	ring	ring	NOUN
ecletica-510	117	17	systems	system	NOUN
ecletica-510	117	18	overlap	overlap	NOUN
ecletica-510	117	19	approximately	approximately	ADV
ecletica-510	117	20	in	in	ADP
ecletica-510	117	21	the	the	DET
ecletica-510	117	22	same	same	ADJ
ecletica-510	117	23	plane	plane	NOUN
ecletica-510	117	24	.	.	PUNCT
ecletica-510	118	1	figure	figure	NOUN
ecletica-510	118	2	3b	3b	PROPN
ecletica-510	118	3	shows	show	VERB
ecletica-510	118	4	the	the	DET
ecletica-510	118	5	atp	atp	NOUN
ecletica-510	118	6	-	-	PUNCT
ecletica-510	118	7	binding	bind	VERB
ecletica-510	118	8	pocket	pocket	NOUN
ecletica-510	118	9	for	for	ADP
ecletica-510	118	10	the	the	DET
ecletica-510	118	11	complexes	complex	NOUN
ecletica-510	118	12	cdk2	cdk2	PROPN
ecletica-510	118	13	:	:	PUNCT
ecletica-510	118	14	atp	atp	PROPN
ecletica-510	118	15	and	and	CCONJ
ecletica-510	118	16	cdk9	cdk9	PROPN
ecletica-510	118	17	:	:	PUNCT
ecletica-510	118	18	flavopiridol	flavopiridol	PROPN
ecletica-510	118	19	.	.	PUNCT
ecletica-510	119	1	the	the	DET
ecletica-510	119	2	cdk	cdk	PROPN
ecletica-510	119	3	structures	structure	NOUN
ecletica-510	119	4	are	be	AUX
ecletica-510	119	5	constituted	constitute	VERB
ecletica-510	119	6	of	of	ADP
ecletica-510	119	7	two	two	NUM
ecletica-510	119	8	lobes	lobe	NOUN
ecletica-510	119	9	and	and	CCONJ
ecletica-510	119	10	two	two	NUM
ecletica-510	119	11	strong	strong	ADJ
ecletica-510	119	12	salt	salt	NOUN
ecletica-510	119	13	bridges	bridge	NOUN
ecletica-510	119	14	are	be	AUX
ecletica-510	119	15	observed	observe	VERB
ecletica-510	119	16	involving	involve	VERB
ecletica-510	119	17	glu	glu	NOUN
ecletica-510	119	18	92	92	NUM
ecletica-510	119	19	lys	lys	NOUN
ecletica-510	119	20	20	20	NUM
ecletica-510	119	21	and	and	CCONJ
ecletica-510	119	22	glu	glu	PROPN
ecletica-510	119	23	92	92	NUM
ecletica-510	119	24	lys	lys	NOUN
ecletica-510	119	25	29	29	NUM
ecletica-510	119	26	in	in	ADP
ecletica-510	119	27	the	the	DET
ecletica-510	119	28	cdk9	cdk9	NOUN
ecletica-510	119	29	:	:	PUNCT
ecletica-510	119	30	flavopiridol	flavopiridol	NOUN
ecletica-510	119	31	structure	structure	NOUN
ecletica-510	119	32	.	.	PUNCT
ecletica-510	120	1	these	these	DET
ecletica-510	120	2	salt	salt	NOUN
ecletica-510	120	3	bridges	bridge	NOUN
ecletica-510	120	4	involve	involve	VERB
ecletica-510	120	5	residues	residue	NOUN
ecletica-510	120	6	from	from	ADP
ecletica-510	120	7	two	two	NUM
ecletica-510	120	8	lobes	lobe	NOUN
ecletica-510	120	9	of	of	ADP
ecletica-510	120	10	the	the	DET
ecletica-510	120	11	cdk9	cdk9	NOUN
ecletica-510	120	12	structure	structure	NOUN
ecletica-510	120	13	and	and	CCONJ
ecletica-510	120	14	they	they	PRON
ecletica-510	120	15	are	be	AUX
ecletica-510	120	16	not	not	PART
ecletica-510	120	17	conserved	conserve	VERB
ecletica-510	120	18	in	in	ADP
ecletica-510	120	19	the	the	DET
ecletica-510	120	20	cdk2	cdk2	PROPN
ecletica-510	120	21	structures	structure	NOUN
ecletica-510	120	22	.	.	PUNCT
ecletica-510	121	1	lys	lys	PROPN
ecletica-510	121	2	20	20	NUM
ecletica-510	121	3	and	and	CCONJ
ecletica-510	121	4	29	29	NUM
ecletica-510	121	5	in	in	ADP
ecletica-510	121	6	the	the	DET
ecletica-510	121	7	n	n	CCONJ
ecletica-510	121	8	-	-	PUNCT
ecletica-510	121	9	terminal	terminal	NOUN
ecletica-510	121	10	lobe	lobe	NOUN
ecletica-510	121	11	and	and	CCONJ
ecletica-510	121	12	glu	glu	NOUN
ecletica-510	121	13	92	92	NUM
ecletica-510	121	14	in	in	ADP
ecletica-510	121	15	the	the	DET
ecletica-510	121	16	c	c	NOUN
ecletica-510	121	17	-	-	PUNCT
ecletica-510	121	18	terminal	terminal	ADJ
ecletica-510	121	19	lobe	lobe	NOUN
ecletica-510	121	20	of	of	ADP
ecletica-510	121	21	cdk2	cdk2	PROPN
ecletica-510	121	22	do	do	AUX
ecletica-510	121	23	not	not	PART
ecletica-510	121	24	form	form	VERB
ecletica-510	121	25	salt	salt	NOUN
ecletica-510	121	26	bridges	bridge	NOUN
ecletica-510	121	27	.	.	PUNCT
ecletica-510	122	1	this	this	DET
ecletica-510	122	2	strong	strong	ADJ
ecletica-510	122	3	electrostatic	electrostatic	ADJ
ecletica-510	122	4	interaction	interaction	NOUN
ecletica-510	122	5	brings	bring	VERB
ecletica-510	122	6	the	the	DET
ecletica-510	122	7	two	two	NUM
ecletica-510	122	8	lobes	lobe	NOUN
ecletica-510	122	9	of	of	ADP
ecletica-510	122	10	cdk9	cdk9	PROPN
ecletica-510	122	11	closer	close	ADV
ecletica-510	122	12	,	,	PUNCT
ecletica-510	122	13	which	which	PRON
ecletica-510	122	14	increases	increase	VERB
ecletica-510	122	15	the	the	DET
ecletica-510	122	16	enzyme	enzyme	NOUN
ecletica-510	122	17	-	-	PUNCT
ecletica-510	122	18	inhibitor	inhibitor	NOUN
ecletica-510	122	19	contact	contact	NOUN
ecletica-510	122	20	area	area	NOUN
ecletica-510	122	21	,	,	PUNCT
ecletica-510	122	22	however	however	SCONJ
ecletica-510	122	23	cdk9	cdk9	PROPN
ecletica-510	122	24	makes	make	VERB
ecletica-510	122	25	only	only	ADV
ecletica-510	122	26	three	three	NUM
ecletica-510	122	27	hydrogen	hydrogen	NOUN
ecletica-510	122	28	bonds	bond	NOUN
ecletica-510	122	29	with	with	ADP
ecletica-510	122	30	flavopiridol	flavopiridol	PROPN
ecletica-510	122	31	.	.	PUNCT
ecletica-510	123	1	figure	figure	NOUN
ecletica-510	123	2	4	4	NUM
ecletica-510	123	3	:	:	PUNCT
ecletica-510	123	4	shows	show	VERB
ecletica-510	123	5	the	the	DET
ecletica-510	123	6	position	position	NOUN
ecletica-510	123	7	of	of	ADP
ecletica-510	123	8	the	the	DET
ecletica-510	123	9	salt	salt	NOUN
ecletica-510	123	10	bridges	bridge	NOUN
ecletica-510	123	11	in	in	ADP
ecletica-510	123	12	the	the	DET
ecletica-510	123	13	cdk9	cdk9	NOUN
ecletica-510	123	14	structure	structure	NOUN
ecletica-510	123	15	.	.	PUNCT
ecletica-510	124	1	furthermore	furthermore	ADV
ecletica-510	124	2	,	,	PUNCT
ecletica-510	124	3	the	the	DET
ecletica-510	124	4	side	side	NOUN
ecletica-510	124	5	chains	chain	NOUN
ecletica-510	124	6	of	of	ADP
ecletica-510	124	7	glu	glu	NOUN
ecletica-510	124	8	92	92	NUM
ecletica-510	124	9	,	,	PUNCT
ecletica-510	124	10	lys	lys	PROPN
ecletica-510	124	11	20	20	NUM
ecletica-510	124	12	and	and	CCONJ
ecletica-510	124	13	lys	lys	PROPN
ecletica-510	124	14	29	29	NUM
ecletica-510	124	15	bring	bring	VERB
ecletica-510	124	16	the	the	DET
ecletica-510	124	17	phenyl	phenyl	NOUN
ecletica-510	124	18	of	of	ADP
ecletica-510	124	19	phe	phe	PROPN
ecletica-510	124	20	90	90	NUM
ecletica-510	124	21	to	to	ADP
ecletica-510	124	22	a	a	DET
ecletica-510	124	23	position	position	NOUN
ecletica-510	124	24	deeper	deeply	ADV
ecletica-510	124	25	in	in	ADP
ecletica-510	124	26	the	the	DET
ecletica-510	124	27	binding	bind	VERB
ecletica-510	124	28	pocket	pocket	NOUN
ecletica-510	124	29	,	,	PUNCT
ecletica-510	124	30	which	which	PRON
ecletica-510	124	31	also	also	ADV
ecletica-510	124	32	contributes	contribute	VERB
ecletica-510	124	33	to	to	PART
ecletica-510	124	34	increase	increase	VERB
ecletica-510	124	35	the	the	DET
ecletica-510	124	36	contact	contact	NOUN
ecletica-510	124	37	area	area	NOUN
ecletica-510	124	38	between	between	ADP
ecletica-510	124	39	flavopiridol	flavopiridol	NOUN
ecletica-510	124	40	and	and	CCONJ
ecletica-510	124	41	cdk9	cdk9	PROPN
ecletica-510	124	42	.	.	PUNCT
ecletica-510	125	1	figure	figure	VERB
ecletica-510	125	2	4	4	NUM
ecletica-510	125	3	:	:	PUNCT
ecletica-510	125	4	ribbon	ribbon	NOUN
ecletica-510	125	5	diagram	diagram	NOUN
ecletica-510	125	6	of	of	ADP
ecletica-510	125	7	the	the	DET
ecletica-510	125	8	human	human	ADJ
ecletica-510	125	9	cdk9	cdk9	PROPN
ecletica-510	125	10	generated	generate	VERB
ecletica-510	125	11	by	by	ADP
ecletica-510	125	12	molscript	molscript	NOUN
ecletica-510	125	13	(	(	PUNCT
ecletica-510	125	14	35	35	NUM
ecletica-510	125	15	)	)	PUNCT
ecletica-510	125	16	showing	show	VERB
ecletica-510	125	17	the	the	DET
ecletica-510	125	18	residues	residue	NOUN
ecletica-510	125	19	lys	lys	NOUN
ecletica-510	125	20	20	20	NUM
ecletica-510	125	21	,	,	PUNCT
ecletica-510	125	22	lys	lys	PROPN
ecletica-510	125	23	29	29	NUM
ecletica-510	125	24	,	,	PUNCT
ecletica-510	125	25	phe	phe	NOUN
ecletica-510	125	26	90	90	NUM
ecletica-510	125	27	and	and	CCONJ
ecletica-510	125	28	glu	glu	PROPN
ecletica-510	125	29	92	92	NUM
ecletica-510	125	30	.	.	PUNCT
ecletica-510	126	1	chao	chao	PROPN
ecletica-510	126	2	et	et	PROPN
ecletica-510	126	3	al	al	PROPN
ecletica-510	126	4	.	.	PROPN
ecletica-510	126	5	,	,	PUNCT
ecletica-510	126	6	(	(	PUNCT
ecletica-510	126	7	2000	2000	NUM
ecletica-510	126	8	)	)	PUNCT
ecletica-510	126	9	performed	perform	VERB
ecletica-510	126	10	a	a	DET
ecletica-510	126	11	functional	functional	ADJ
ecletica-510	126	12	study	study	NOUN
ecletica-510	126	13	of	of	ADP
ecletica-510	126	14	inhibition	inhibition	NOUN
ecletica-510	126	15	of	of	ADP
ecletica-510	126	16	cdk9	cdk9	NOUN
ecletica-510	126	17	by	by	ADP
ecletica-510	126	18	flavopiridol	flavopiridol	PROPN
ecletica-510	126	19	,	,	PUNCT
ecletica-510	126	20	which	which	PRON
ecletica-510	126	21	indicated	indicate	VERB
ecletica-510	126	22	lack	lack	NOUN
ecletica-510	126	23	of	of	ADP
ecletica-510	126	24	competition	competition	NOUN
ecletica-510	126	25	with	with	ADP
ecletica-510	126	26	atp	atp	PROPN
ecletica-510	126	27	,	,	PUNCT
ecletica-510	126	28	suggesting	suggest	VERB
ecletica-510	126	29	the	the	DET
ecletica-510	126	30	presence	presence	NOUN
ecletica-510	126	31	of	of	ADP
ecletica-510	126	32	at	at	ADV
ecletica-510	126	33	least	least	ADV
ecletica-510	126	34	one	one	NUM
ecletica-510	126	35	additional	additional	ADJ
ecletica-510	126	36	binding	bind	VERB
ecletica-510	126	37	site	site	NOUN
ecletica-510	126	38	[	[	X
ecletica-510	126	39	9	9	NUM
ecletica-510	126	40	]	]	PUNCT
ecletica-510	126	41	.	.	PUNCT
ecletica-510	127	1	however	however	ADV
ecletica-510	127	2	a	a	DET
ecletica-510	127	3	close	close	ADJ
ecletica-510	127	4	inspection	inspection	NOUN
ecletica-510	127	5	of	of	ADP
ecletica-510	127	6	the	the	DET
ecletica-510	127	7	structure	structure	NOUN
ecletica-510	127	8	of	of	ADP
ecletica-510	127	9	the	the	DET
ecletica-510	127	10	cdk9	cdk9	PROPN
ecletica-510	127	11	model	model	NOUN
ecletica-510	127	12	did	do	AUX
ecletica-510	127	13	not	not	PART
ecletica-510	127	14	reveal	reveal	VERB
ecletica-510	127	15	the	the	DET
ecletica-510	127	16	presence	presence	NOUN
ecletica-510	127	17	of	of	ADP
ecletica-510	127	18	any	any	DET
ecletica-510	127	19	additional	additional	ADJ
ecletica-510	127	20	binding	binding	ADJ
ecletica-510	127	21	pockets	pocket	NOUN
ecletica-510	127	22	.	.	PUNCT
ecletica-510	128	1	the	the	DET
ecletica-510	128	2	cdk9	cdk9	PROPN
ecletica-510	128	3	:	:	PUNCT
ecletica-510	128	4	flavopiridol	flavopiridol	PROPN
ecletica-510	128	5	model	model	NOUN
ecletica-510	128	6	clearly	clearly	ADV
ecletica-510	128	7	reveals	reveal	VERB
ecletica-510	128	8	a	a	DET
ecletica-510	128	9	very	very	ADV
ecletica-510	128	10	tight	tight	ADJ
ecletica-510	128	11	binding	binding	NOUN
ecletica-510	128	12	of	of	ADP
ecletica-510	128	13	the	the	DET
ecletica-510	128	14	inhibitor	inhibitor	NOUN
ecletica-510	128	15	to	to	ADP
ecletica-510	128	16	the	the	DET
ecletica-510	128	17	enzyme	enzyme	NOUN
ecletica-510	128	18	which	which	PRON
ecletica-510	128	19	may	may	AUX
ecletica-510	128	20	essentially	essentially	ADV
ecletica-510	128	21	inactivate	inactivate	VERB
ecletica-510	128	22	the	the	DET
ecletica-510	128	23	enzyme	enzyme	NOUN
ecletica-510	128	24	,	,	PUNCT
ecletica-510	128	25	in	in	ADP
ecletica-510	128	26	such	such	ADJ
ecletica-510	128	27	scenery	scenery	NOUN
ecletica-510	128	28	a	a	DET
ecletica-510	128	29	competitive	competitive	ADJ
ecletica-510	128	30	kinetic	kinetic	ADJ
ecletica-510	128	31	mechanism	mechanism	NOUN
ecletica-510	128	32	is	be	AUX
ecletica-510	128	33	possible	possible	ADJ
ecletica-510	128	34	.	.	PUNCT
ecletica-510	129	1	50	50	NUM
ecletica-510	129	2	the	the	DET
ecletica-510	129	3	contact	contact	NOUN
ecletica-510	129	4	areas	area	NOUN
ecletica-510	129	5	for	for	ADP
ecletica-510	129	6	the	the	DET
ecletica-510	129	7	complexes	complex	NOUN
ecletica-510	129	8	of	of	ADP
ecletica-510	129	9	cdk2	cdk2	PROPN
ecletica-510	129	10	and	and	CCONJ
ecletica-510	129	11	cdk9	cdk9	PROPN
ecletica-510	129	12	with	with	ADP
ecletica-510	129	13	flavopiridol	flavopiridol	PROPN
ecletica-510	129	14	are	be	AUX
ecletica-510	129	15	320	320	NUM
ecletica-510	129	16	å2	å2	NOUN
ecletica-510	129	17	and	and	CCONJ
ecletica-510	129	18	332	332	NUM
ecletica-510	129	19	å2	å2	NOUN
ecletica-510	129	20	respectively	respectively	ADV
ecletica-510	129	21	,	,	PUNCT
ecletica-510	129	22	which	which	PRON
ecletica-510	129	23	may	may	AUX
ecletica-510	129	24	partially	partially	ADV
ecletica-510	129	25	explain	explain	VERB
ecletica-510	129	26	the	the	DET
ecletica-510	129	27	lower	low	ADJ
ecletica-510	129	28	ic50	ic50	PROPN
ecletica-510	129	29	value	value	NOUN
ecletica-510	129	30	observed	observe	VERB
ecletica-510	129	31	for	for	ADP
ecletica-510	129	32	cdk9	cdk9	NOUN
ecletica-510	129	33	.	.	PUNCT
ecletica-510	130	1	table	table	NOUN
ecletica-510	130	2	4	4	NUM
ecletica-510	130	3	summarizes	summarize	NOUN
ecletica-510	130	4	the	the	DET
ecletica-510	130	5	some	some	DET
ecletica-510	130	6	structural	structural	ADJ
ecletica-510	130	7	results	result	NOUN
ecletica-510	130	8	and	and	CCONJ
ecletica-510	130	9	ic50	ic50	PROPN
ecletica-510	130	10	for	for	ADP
ecletica-510	130	11	cdk2	cdk2	PROPN
ecletica-510	130	12	and	and	CCONJ
ecletica-510	130	13	cdk9	cdk9	PROPN
ecletica-510	130	14	structures	structure	NOUN
ecletica-510	130	15	.	.	PUNCT
ecletica-510	131	1	the	the	DET
ecletica-510	131	2	overall	overall	ADJ
ecletica-510	131	3	structure	structure	NOUN
ecletica-510	131	4	of	of	ADP
ecletica-510	131	5	the	the	DET
ecletica-510	131	6	complex	complex	NOUN
ecletica-510	131	7	indicates	indicate	VERB
ecletica-510	131	8	that	that	SCONJ
ecletica-510	131	9	the	the	DET
ecletica-510	131	10	flavopiridol	flavopiridol	NOUN
ecletica-510	131	11	is	be	AUX
ecletica-510	131	12	tightly	tightly	ADV
ecletica-510	131	13	bound	bind	VERB
ecletica-510	131	14	to	to	ADP
ecletica-510	131	15	the	the	DET
ecletica-510	131	16	atp	atp	NOUN
ecletica-510	131	17	-	-	PUNCT
ecletica-510	131	18	binding	bind	VERB
ecletica-510	131	19	pocket	pocket	NOUN
ecletica-510	131	20	and	and	CCONJ
ecletica-510	131	21	since	since	SCONJ
ecletica-510	131	22	no	no	DET
ecletica-510	131	23	further	far	ADV
ecletica-510	131	24	binding	bind	VERB
ecletica-510	131	25	sites	site	NOUN
ecletica-510	131	26	were	be	AUX
ecletica-510	131	27	identified	identify	VERB
ecletica-510	131	28	in	in	ADP
ecletica-510	131	29	the	the	DET
ecletica-510	131	30	cdk9	cdk9	NOUN
ecletica-510	131	31	structure	structure	NOUN
ecletica-510	131	32	we	we	PRON
ecletica-510	131	33	have	have	VERB
ecletica-510	131	34	strong	strong	ADJ
ecletica-510	131	35	structural	structural	ADJ
ecletica-510	131	36	evidence	evidence	NOUN
ecletica-510	131	37	that	that	SCONJ
ecletica-510	131	38	flavopiridol	flavopiridol	PROPN
ecletica-510	131	39	is	be	AUX
ecletica-510	131	40	a	a	DET
ecletica-510	131	41	competitive	competitive	ADJ
ecletica-510	131	42	inhibitor	inhibitor	NOUN
ecletica-510	131	43	with	with	ADP
ecletica-510	131	44	atp	atp	PROPN
ecletica-510	131	45	.	.	PROPN
ecletica-510	131	46	table	table	PROPN
ecletica-510	131	47	4	4	NUM
ecletica-510	131	48	:	:	PUNCT
ecletica-510	131	49	summary	summary	NOUN
ecletica-510	131	50	of	of	ADP
ecletica-510	131	51	structural	structural	ADJ
ecletica-510	131	52	results	result	NOUN
ecletica-510	131	53	for	for	ADP
ecletica-510	131	54	cdk2	cdk2	NOUN
ecletica-510	131	55	and	and	CCONJ
ecletica-510	131	56	cdk9	cdk9	PROPN
ecletica-510	131	57	.	.	PUNCT
ecletica-510	132	1	the	the	DET
ecletica-510	132	2	simple	simple	ADJ
ecletica-510	132	3	paradigm	paradigm	NOUN
ecletica-510	132	4	of	of	ADP
ecletica-510	132	5	the	the	DET
ecletica-510	132	6	molecular	molecular	ADJ
ecletica-510	132	7	fork	fork	NOUN
ecletica-510	132	8	,	,	PUNCT
ecletica-510	132	9	also	also	ADV
ecletica-510	132	10	identified	identify	VERB
ecletica-510	132	11	in	in	ADP
ecletica-510	132	12	the	the	DET
ecletica-510	132	13	cdk9	cdk9	NOUN
ecletica-510	132	14	structure	structure	NOUN
ecletica-510	132	15	,	,	PUNCT
ecletica-510	132	16	suggests	suggest	VERB
ecletica-510	132	17	that	that	SCONJ
ecletica-510	132	18	cdk9	cdk9	PROPN
ecletica-510	132	19	may	may	AUX
ecletica-510	132	20	also	also	ADV
ecletica-510	132	21	be	be	AUX
ecletica-510	132	22	strongly	strongly	ADV
ecletica-510	132	23	inhibited	inhibit	VERB
ecletica-510	132	24	by	by	ADP
ecletica-510	132	25	other	other	ADJ
ecletica-510	132	26	cdk2	cdk2	PROPN
ecletica-510	132	27	inhibitors	inhibitor	NOUN
ecletica-510	132	28	,	,	PUNCT
ecletica-510	132	29	such	such	ADJ
ecletica-510	132	30	as	as	ADP
ecletica-510	132	31	roscovitine	roscovitine	NOUN
ecletica-510	132	32	,	,	PUNCT
ecletica-510	132	33	olomoucine	olomoucine	NOUN
ecletica-510	132	34	,	,	PUNCT
ecletica-510	132	35	and	and	CCONJ
ecletica-510	132	36	staurosporine	staurosporine	VERB
ecletica-510	132	37	.	.	PUNCT
ecletica-510	133	1	further	far	ADV
ecletica-510	133	2	inhibition	inhibition	NOUN
ecletica-510	133	3	experiments	experiment	NOUN
ecletica-510	133	4	may	may	AUX
ecletica-510	133	5	confirm	confirm	VERB
ecletica-510	133	6	this	this	DET
ecletica-510	133	7	prediction	prediction	NOUN
ecletica-510	133	8	.	.	PUNCT
ecletica-510	134	1	figure	figure	NOUN
ecletica-510	134	2	5	5	NUM
ecletica-510	134	3	shows	show	VERB
ecletica-510	134	4	a	a	DET
ecletica-510	134	5	schematic	schematic	ADJ
ecletica-510	134	6	diagram	diagram	NOUN
ecletica-510	134	7	for	for	ADP
ecletica-510	134	8	this	this	DET
ecletica-510	134	9	molecular	molecular	ADJ
ecletica-510	134	10	fork	fork	NOUN
ecletica-510	134	11	.	.	PUNCT
ecletica-510	135	1	it	it	PRON
ecletica-510	135	2	has	have	AUX
ecletica-510	135	3	been	be	AUX
ecletica-510	135	4	observed	observe	VERB
ecletica-510	135	5	that	that	SCONJ
ecletica-510	135	6	the	the	DET
ecletica-510	135	7	complex	complex	ADJ
ecletica-510	135	8	cdk9	cdk9	PROPN
ecletica-510	135	9	-	-	PUNCT
ecletica-510	135	10	cyclin	cyclin	PROPN
ecletica-510	135	11	t1	t1	NOUN
ecletica-510	135	12	is	be	AUX
ecletica-510	135	13	a	a	DET
ecletica-510	135	14	key	key	ADJ
ecletica-510	135	15	factor	factor	NOUN
ecletica-510	135	16	in	in	ADP
ecletica-510	135	17	hiv-1	hiv-1	ADJ
ecletica-510	135	18	infection	infection	NOUN
ecletica-510	135	19	and	and	CCONJ
ecletica-510	135	20	flavopiridol	flavopiridol	NOUN
ecletica-510	135	21	blocks	block	NOUN
ecletica-510	135	22	hiv-1	hiv-1	PART
ecletica-510	135	23	propagation	propagation	NOUN
ecletica-510	135	24	in	in	ADP
ecletica-510	135	25	cultured	cultured	ADJ
ecletica-510	135	26	cells	cell	NOUN
ecletica-510	135	27	.	.	PUNCT
ecletica-510	136	1	furthermore	furthermore	ADV
ecletica-510	136	2	,	,	PUNCT
ecletica-510	136	3	it	it	PRON
ecletica-510	136	4	has	have	AUX
ecletica-510	136	5	been	be	AUX
ecletica-510	136	6	suggested	suggest	VERB
ecletica-510	136	7	that	that	SCONJ
ecletica-510	136	8	flavopiridol	flavopiridol	PROPN
ecletica-510	136	9	should	should	AUX
ecletica-510	136	10	be	be	AUX
ecletica-510	136	11	evaluated	evaluate	VERB
ecletica-510	136	12	in	in	ADP
ecletica-510	136	13	aids	aid	NOUN
ecletica-510	136	14	therapy	therapy	NOUN
ecletica-510	137	1	[	[	X
ecletica-510	137	2	9	9	NUM
ecletica-510	137	3	]	]	PUNCT
ecletica-510	137	4	so	so	SCONJ
ecletica-510	137	5	that	that	SCONJ
ecletica-510	137	6	the	the	DET
ecletica-510	137	7	cdk9	cdk9	PROPN
ecletica-510	137	8	structural	structural	ADJ
ecletica-510	137	9	model	model	NOUN
ecletica-510	137	10	can	can	AUX
ecletica-510	137	11	be	be	AUX
ecletica-510	137	12	used	use	VERB
ecletica-510	137	13	for	for	ADP
ecletica-510	137	14	designing	design	VERB
ecletica-510	137	15	new	new	ADJ
ecletica-510	137	16	active	active	ADJ
ecletica-510	137	17	cdk9	cdk9	NOUN
ecletica-510	137	18	inhibitors	inhibitor	NOUN
ecletica-510	137	19	.	.	PUNCT
ecletica-510	138	1	figure	figure	VERB
ecletica-510	138	2	5	5	NUM
ecletica-510	138	3	:	:	PUNCT
ecletica-510	138	4	schematic	schematic	ADJ
ecletica-510	138	5	diagram	diagram	NOUN
ecletica-510	138	6	of	of	ADP
ecletica-510	138	7	the	the	DET
ecletica-510	138	8	molecular	molecular	ADJ
ecletica-510	138	9	fork	fork	NOUN
ecletica-510	138	10	.	.	PUNCT
ecletica-510	139	1	residues	residue	NOUN
ecletica-510	139	2	from	from	ADP
ecletica-510	139	3	i	i	PRON
ecletica-510	139	4	to	to	ADP
ecletica-510	139	5	i+2	i+2	PRON
ecletica-510	139	6	are	be	AUX
ecletica-510	139	7	glu81	glu81	NOUN
ecletica-510	139	8	,	,	PUNCT
ecletica-510	139	9	phe82	phe82	PROPN
ecletica-510	139	10	,	,	PUNCT
ecletica-510	139	11	leu83	leu83	NOUN
ecletica-510	139	12	and	and	CCONJ
ecletica-510	139	13	asp89	asp89	PROPN
ecletica-510	139	14	,	,	PUNCT
ecletica-510	139	15	phe90	phe90	NOUN
ecletica-510	139	16	,	,	PUNCT
ecletica-510	139	17	cys91	cys91	NOUN
ecletica-510	139	18	for	for	ADP
ecletica-510	139	19	cdk2	cdk2	PROPN
ecletica-510	139	20	and	and	CCONJ
ecletica-510	139	21	cdk9	cdk9	PROPN
ecletica-510	139	22	,	,	PUNCT
ecletica-510	139	23	respectively	respectively	ADV
ecletica-510	139	24	.	.	PUNCT
ecletica-510	140	1	interactions	interaction	NOUN
ecletica-510	140	2	of	of	ADP
ecletica-510	140	3	roscovitine	roscovitine	NOUN
ecletica-510	140	4	with	with	ADP
ecletica-510	140	5	cdk5	cdk5	PROPN
ecletica-510	140	6	it	it	PRON
ecletica-510	140	7	was	be	AUX
ecletica-510	140	8	observed	observe	VERB
ecletica-510	140	9	a	a	DET
ecletica-510	140	10	total	total	ADJ
ecletica-510	140	11	three	three	NUM
ecletica-510	140	12	hydrogen	hydrogen	NOUN
ecletica-510	140	13	bonds	bond	NOUN
ecletica-510	140	14	between	between	ADP
ecletica-510	140	15	cdk5	cdk5	NOUN
ecletica-510	140	16	and	and	CCONJ
ecletica-510	140	17	roscovitine	roscovitine	NOUN
ecletica-510	140	18	,	,	PUNCT
ecletica-510	140	19	in	in	ADP
ecletica-510	140	20	binary	binary	PROPN
ecletica-510	140	21	model	model	NOUN
ecletica-510	140	22	,	,	PUNCT
ecletica-510	140	23	involving	involve	VERB
ecletica-510	140	24	the	the	DET
ecletica-510	140	25	residues	residue	NOUN
ecletica-510	140	26	cys83	cys83	NOUN
ecletica-510	140	27	,	,	PUNCT
ecletica-510	140	28	asp86	asp86	NOUN
ecletica-510	140	29	,	,	PUNCT
ecletica-510	140	30	and	and	CCONJ
ecletica-510	140	31	gln130	gln130	PROPN
ecletica-510	140	32	.	.	PUNCT
ecletica-510	141	1	for	for	ADP
ecletica-510	141	2	the	the	DET
ecletica-510	141	3	cdk2	cdk2	PROPN
ecletica-510	141	4	:	:	PUNCT
ecletica-510	141	5	roscovitine	roscovitine	PROPN
ecletica-510	141	6	model	model	NOUN
ecletica-510	141	7	two	two	NUM
ecletica-510	141	8	hydrogen	hydrogen	NOUN
ecletica-510	141	9	bonds	bond	NOUN
ecletica-510	141	10	involving	involve	VERB
ecletica-510	141	11	the	the	DET
ecletica-510	141	12	residue	residue	NOUN
ecletica-510	141	13	leu83	leu83	NOUN
ecletica-510	141	14	were	be	AUX
ecletica-510	141	15	observed	observe	VERB
ecletica-510	141	16	.	.	PUNCT
ecletica-510	142	1	table	table	NOUN
ecletica-510	142	2	5	5	NUM
ecletica-510	142	3	shows	show	VERB
ecletica-510	142	4	the	the	DET
ecletica-510	142	5	intermolecular	intermolecular	ADJ
ecletica-510	142	6	hydrogen	hydrogen	NOUN
ecletica-510	142	7	bonds	bond	NOUN
ecletica-510	142	8	for	for	ADP
ecletica-510	142	9	both	both	DET
ecletica-510	142	10	complexes	complex	NOUN
ecletica-510	142	11	.	.	PUNCT
ecletica-510	143	1	the	the	DET
ecletica-510	143	2	higher	high	ADJ
ecletica-510	143	3	number	number	NOUN
ecletica-510	143	4	of	of	ADP
ecletica-510	143	5	intermolecular	intermolecular	ADJ
ecletica-510	143	6	hydrogen	hydrogen	NOUN
ecletica-510	143	7	bonds	bond	NOUN
ecletica-510	143	8	,	,	PUNCT
ecletica-510	143	9	observed	observe	VERB
ecletica-510	143	10	in	in	ADP
ecletica-510	143	11	the	the	DET
ecletica-510	143	12	cdk5	cdk5	PROPN
ecletica-510	143	13	:	:	PUNCT
ecletica-510	143	14	roscovitine	roscovitine	PROPN
ecletica-510	143	15	complex	complex	NOUN
ecletica-510	143	16	,	,	PUNCT
ecletica-510	143	17	is	be	AUX
ecletica-510	143	18	probably	probably	ADV
ecletica-510	143	19	due	due	ADJ
ecletica-510	143	20	to	to	ADP
ecletica-510	143	21	the	the	DET
ecletica-510	143	22	modification	modification	NOUN
ecletica-510	143	23	of	of	ADP
ecletica-510	143	24	his84	his84	NOUN
ecletica-510	143	25	(	(	PUNCT
ecletica-510	143	26	cdk2	cdk2	PROPN
ecletica-510	143	27	)	)	PUNCT
ecletica-510	143	28	to	to	ADP
ecletica-510	143	29	asp	asp	PROPN
ecletica-510	143	30	in	in	ADP
ecletica-510	143	31	the	the	DET
ecletica-510	143	32	cdk5	cdk5	PROPN
ecletica-510	143	33	sequence	sequence	NOUN
ecletica-510	143	34	,	,	PUNCT
ecletica-510	143	35	which	which	PRON
ecletica-510	143	36	allows	allow	VERB
ecletica-510	143	37	an	an	DET
ecletica-510	143	38	additional	additional	ADJ
ecletica-510	143	39	salt	salt	NOUN
ecletica-510	143	40	-	-	PUNCT
ecletica-510	143	41	bridge	bridge	NOUN
ecletica-510	143	42	in	in	ADP
ecletica-510	143	43	the	the	DET
ecletica-510	143	44	cdk5	cdk5	PROPN
ecletica-510	143	45	structure	structure	NOUN
ecletica-510	143	46	,	,	PUNCT
ecletica-510	143	47	involving	involve	VERB
ecletica-510	143	48	asp84	asp84	PROPN
ecletica-510	143	49	and	and	CCONJ
ecletica-510	143	50	lys20	lys20	PROPN
ecletica-510	143	51	.	.	PUNCT
ecletica-510	144	1	this	this	DET
ecletica-510	144	2	salt	salt	NOUN
ecletica-510	144	3	-	-	PUNCT
ecletica-510	144	4	bridge	bridge	NOUN
ecletica-510	144	5	moves	move	VERB
ecletica-510	144	6	the	the	DET
ecletica-510	144	7	inhibitor	inhibitor	NOUN
ecletica-510	144	8	away	away	ADV
ecletica-510	144	9	from	from	ADP
ecletica-510	144	10	the	the	DET
ecletica-510	144	11	molecular	molecular	ADJ
ecletica-510	144	12	fork	fork	NOUN
ecletica-510	144	13	of	of	ADP
ecletica-510	144	14	cdk5	cdk5	PROPN
ecletica-510	144	15	,	,	PUNCT
ecletica-510	144	16	however	however	ADV
ecletica-510	144	17	keeping	keep	VERB
ecletica-510	144	18	the	the	DET
ecletica-510	144	19	intermolecular	intermolecular	ADJ
ecletica-510	144	20	hydrogen	hydrogen	NOUN
ecletica-510	144	21	bonds	bond	NOUN
ecletica-510	144	22	between	between	ADP
ecletica-510	144	23	the	the	DET
ecletica-510	144	24	molecular	molecular	ADJ
ecletica-510	144	25	fork	fork	NOUN
ecletica-510	144	26	and	and	CCONJ
ecletica-510	144	27	roscovitine	roscovitine	NOUN
ecletica-510	144	28	.	.	PUNCT
ecletica-510	145	1	nevertheless	nevertheless	ADV
ecletica-510	145	2	,	,	PUNCT
ecletica-510	145	3	this	this	DET
ecletica-510	145	4	movement	movement	NOUN
ecletica-510	145	5	brings	bring	VERB
ecletica-510	145	6	roscovitine	roscovitine	ADV
ecletica-510	145	7	closer	close	ADV
ecletica-510	145	8	to	to	ADP
ecletica-510	145	9	the	the	DET
ecletica-510	145	10	side	side	NOUN
ecletica-510	145	11	chains	chain	NOUN
ecletica-510	145	12	of	of	ADP
ecletica-510	145	13	gln130	gln130	PROPN
ecletica-510	145	14	and	and	CCONJ
ecletica-510	145	15	asp86	asp86	PROPN
ecletica-510	145	16	,	,	PUNCT
ecletica-510	145	17	allowing	allow	VERB
ecletica-510	145	18	additional	additional	ADJ
ecletica-510	145	19	intermolecular	intermolecular	ADJ
ecletica-510	145	20	hydrogen	hydrogen	NOUN
ecletica-510	145	21	bonds	bond	NOUN
ecletica-510	145	22	.	.	PUNCT
ecletica-510	146	1	figure	figure	VERB
ecletica-510	146	2	6	6	NUM
ecletica-510	146	3	:	:	PUNCT
ecletica-510	146	4	superimposed	superimpose	VERB
ecletica-510	146	5	binding	bind	VERB
ecletica-510	146	6	pockets	pocket	NOUN
ecletica-510	146	7	of	of	ADP
ecletica-510	146	8	cdk5	cdk5	NOUN
ecletica-510	146	9	:	:	PUNCT
ecletica-510	146	10	roscovitine	roscovitine	PROPN
ecletica-510	146	11	complex	complex	ADJ
ecletica-510	146	12	(	(	PUNCT
ecletica-510	146	13	thick	thick	ADJ
ecletica-510	146	14	line	line	NOUN
ecletica-510	146	15	)	)	PUNCT
ecletica-510	146	16	and	and	CCONJ
ecletica-510	146	17	cdk2	cdk2	PROPN
ecletica-510	146	18	:	:	PUNCT
ecletica-510	146	19	atp	atp	PROPN
ecletica-510	146	20	complex	complex	NOUN
ecletica-510	146	21	(	(	PUNCT
ecletica-510	146	22	thin	thin	ADJ
ecletica-510	146	23	line	line	NOUN
ecletica-510	146	24	)	)	PUNCT
ecletica-510	146	25	(	(	PUNCT
ecletica-510	146	26	rmsd	rmsd	NOUN
ecletica-510	146	27	value	value	NOUN
ecletica-510	146	28	for	for	ADP
ecletica-510	146	29	cα	cα	ADP
ecletica-510	146	30	:	:	PUNCT
ecletica-510	146	31	0.576å	0.576å	ADJ
ecletica-510	146	32	)	)	PUNCT
ecletica-510	146	33	table	table	NOUN
ecletica-510	146	34	5	5	NUM
ecletica-510	146	35	:	:	PUNCT
ecletica-510	146	36	intermolecular	intermolecular	ADJ
ecletica-510	146	37	hydrogen	hydrogen	NOUN
ecletica-510	146	38	bonds	bond	NOUN
ecletica-510	146	39	between	between	ADP
ecletica-510	146	40	cdk2	cdk2	PROPN
ecletica-510	146	41	and	and	CCONJ
ecletica-510	146	42	roscovitine	roscovitine	NOUN
ecletica-510	146	43	,	,	PUNCT
ecletica-510	146	44	and	and	CCONJ
ecletica-510	146	45	cdk5	cdk5	NOUN
ecletica-510	146	46	and	and	CCONJ
ecletica-510	146	47	roscovitine	roscovitine	NOUN
ecletica-510	146	48	.	.	PUNCT
ecletica-510	147	1	superposition	superposition	NOUN
ecletica-510	147	2	of	of	ADP
ecletica-510	147	3	the	the	DET
ecletica-510	147	4	cdk2	cdk2	PROPN
ecletica-510	147	5	:	:	PUNCT
ecletica-510	147	6	atp	atp	NOUN
ecletica-510	147	7	onto	onto	ADP
ecletica-510	147	8	cdk5	cdk5	PROPN
ecletica-510	147	9	:	:	PUNCT
ecletica-510	147	10	roscovitine	roscovitine	ADJ
ecletica-510	147	11	structure	structure	NOUN
ecletica-510	147	12	indicates	indicate	VERB
ecletica-510	147	13	that	that	SCONJ
ecletica-510	147	14	the	the	DET
ecletica-510	147	15	two	two	NUM
ecletica-510	147	16	ring	ring	NOUN
ecletica-510	147	17	systems	system	NOUN
ecletica-510	147	18	of	of	ADP
ecletica-510	147	19	roscovitine	roscovitine	NOUN
ecletica-510	147	20	and	and	CCONJ
ecletica-510	147	21	atp	atp	PROPN
ecletica-510	147	22	overlap	overlap	NOUN
ecletica-510	147	23	approximately	approximately	ADV
ecletica-510	147	24	in	in	ADP
ecletica-510	147	25	the	the	DET
ecletica-510	147	26	same	same	ADJ
ecletica-510	147	27	plane	plane	NOUN
ecletica-510	147	28	,	,	PUNCT
ecletica-510	147	29	however	however	ADV
ecletica-510	147	30	with	with	ADP
ecletica-510	147	31	different	different	ADJ
ecletica-510	147	32	orientations	orientation	NOUN
ecletica-510	147	33	.	.	PUNCT
ecletica-510	148	1	as	as	SCONJ
ecletica-510	148	2	observed	observe	VERB
ecletica-510	148	3	for	for	ADP
ecletica-510	148	4	the	the	DET
ecletica-510	148	5	crystallographic	crystallographic	ADJ
ecletica-510	148	6	structure	structure	NOUN
ecletica-510	148	7	of	of	ADP
ecletica-510	148	8	the	the	DET
ecletica-510	148	9	cdk2	cdk2	PROPN
ecletica-510	148	10	:	:	PUNCT
ecletica-510	149	1	roscovitine	roscovitine	PROPN
ecletica-510	149	2	complex	complex	ADJ
ecletica-510	150	1	[	[	X
ecletica-510	150	2	16	16	NUM
ecletica-510	150	3	]	]	PUNCT
ecletica-510	150	4	the	the	DET
ecletica-510	150	5	region	region	NOUN
ecletica-510	150	6	of	of	ADP
ecletica-510	150	7	cdk5	cdk5	PROPN
ecletica-510	150	8	occupied	occupy	VERB
ecletica-510	150	9	by	by	ADP
ecletica-510	150	10	the	the	DET
ecletica-510	150	11	pheecl	pheecl	NOUN
ecletica-510	150	12	.	.	PUNCT
ecletica-510	151	1	quím	quím	PROPN
ecletica-510	151	2	.	.	PUNCT
ecletica-510	152	1	,	,	PUNCT
ecletica-510	152	2	são	são	PROPN
ecletica-510	152	3	paulo	paulo	PROPN
ecletica-510	152	4	,	,	PUNCT
ecletica-510	152	5	28(1	28(1	NOUN
ecletica-510	152	6	):	):	PUNCT
ecletica-510	152	7	45	45	NUM
ecletica-510	152	8	-	-	SYM
ecletica-510	152	9	53	53	NUM
ecletica-510	152	10	,	,	PUNCT
ecletica-510	152	11	2003	2003	NUM
ecletica-510	152	12	51	51	NUM
ecletica-510	152	13	nyl	nyl	NOUN
ecletica-510	152	14	ring	ring	NOUN
ecletica-510	152	15	of	of	ADP
ecletica-510	152	16	roscovitine	roscovitine	NOUN
ecletica-510	152	17	is	be	AUX
ecletica-510	152	18	pointing	point	VERB
ecletica-510	152	19	away	away	ADV
ecletica-510	152	20	from	from	ADP
ecletica-510	152	21	the	the	DET
ecletica-510	152	22	atp	atp	NOUN
ecletica-510	152	23	-	-	PUNCT
ecletica-510	152	24	binding	bind	VERB
ecletica-510	152	25	pocket	pocket	NOUN
ecletica-510	152	26	,	,	PUNCT
ecletica-510	152	27	and	and	CCONJ
ecletica-510	152	28	partially	partially	ADV
ecletica-510	152	29	exposed	expose	VERB
ecletica-510	152	30	to	to	ADP
ecletica-510	152	31	solvent	solvent	NOUN
ecletica-510	152	32	.	.	PUNCT
ecletica-510	153	1	figure	figure	NOUN
ecletica-510	153	2	6	6	NUM
ecletica-510	153	3	shows	show	VERB
ecletica-510	153	4	the	the	DET
ecletica-510	153	5	atp	atp	NOUN
ecletica-510	153	6	-	-	PUNCT
ecletica-510	153	7	binding	bind	VERB
ecletica-510	153	8	pocket	pocket	NOUN
ecletica-510	153	9	for	for	ADP
ecletica-510	153	10	the	the	DET
ecletica-510	153	11	complexes	complex	NOUN
ecletica-510	153	12	cdk2	cdk2	PROPN
ecletica-510	153	13	:	:	PUNCT
ecletica-510	153	14	atp	atp	PROPN
ecletica-510	153	15	and	and	CCONJ
ecletica-510	153	16	cdk5	cdk5	PROPN
ecletica-510	153	17	:	:	PUNCT
ecletica-510	153	18	roscovitine	roscovitine	ADJ
ecletica-510	153	19	.	.	PUNCT
ecletica-510	154	1	interactions	interaction	NOUN
ecletica-510	154	2	of	of	ADP
ecletica-510	154	3	flavopiridol	flavopiridol	NOUN
ecletica-510	154	4	and	and	CCONJ
ecletica-510	154	5	roscovitine	roscovitine	NOUN
ecletica-510	154	6	with	with	ADP
ecletica-510	154	7	cdk1	cdk1	PROPN
ecletica-510	154	8	a	a	DET
ecletica-510	154	9	total	total	NOUN
ecletica-510	154	10	of	of	ADP
ecletica-510	154	11	five	five	NUM
ecletica-510	154	12	hydrogen	hydrogen	NOUN
ecletica-510	154	13	bonds	bond	NOUN
ecletica-510	154	14	between	between	ADP
ecletica-510	154	15	cdk1	cdk1	PROPN
ecletica-510	154	16	and	and	CCONJ
ecletica-510	154	17	flavopiridol	flavopiridol	NOUN
ecletica-510	154	18	,	,	PUNCT
ecletica-510	154	19	involving	involve	VERB
ecletica-510	154	20	the	the	DET
ecletica-510	154	21	residues	residue	NOUN
ecletica-510	154	22	lys33	lys33	NOUN
ecletica-510	154	23	,	,	PUNCT
ecletica-510	154	24	glu81	glu81	PROPN
ecletica-510	154	25	,	,	PUNCT
ecletica-510	154	26	leu83	leu83	NOUN
ecletica-510	154	27	,	,	PUNCT
ecletica-510	154	28	and	and	CCONJ
ecletica-510	154	29	asp146	asp146	PROPN
ecletica-510	154	30	were	be	AUX
ecletica-510	154	31	observed	observe	VERB
ecletica-510	154	32	for	for	ADP
ecletica-510	154	33	the	the	DET
ecletica-510	154	34	binary	binary	PROPN
ecletica-510	154	35	complex	complex	PROPN
ecletica-510	154	36	.	.	PUNCT
ecletica-510	155	1	table	table	NOUN
ecletica-510	155	2	6	6	NUM
ecletica-510	155	3	shows	show	VERB
ecletica-510	155	4	the	the	DET
ecletica-510	155	5	intermolecular	intermolecular	ADJ
ecletica-510	155	6	hydrogen	hydrogen	NOUN
ecletica-510	155	7	bonds	bond	NOUN
ecletica-510	155	8	for	for	ADP
ecletica-510	155	9	structure	structure	NOUN
ecletica-510	155	10	of	of	ADP
ecletica-510	155	11	flavopiridol	flavopiridol	NOUN
ecletica-510	155	12	complexed	complexe	VERB
ecletica-510	155	13	with	with	ADP
ecletica-510	155	14	cdk1	cdk1	PROPN
ecletica-510	155	15	.	.	PUNCT
ecletica-510	156	1	it	it	PRON
ecletica-510	156	2	was	be	AUX
ecletica-510	156	3	observed	observe	VERB
ecletica-510	156	4	a	a	DET
ecletica-510	156	5	total	total	NOUN
ecletica-510	156	6	of	of	ADP
ecletica-510	156	7	four	four	NUM
ecletica-510	156	8	hydrogen	hydrogen	NOUN
ecletica-510	156	9	bonds	bond	NOUN
ecletica-510	156	10	between	between	ADP
ecletica-510	156	11	cdk1	cdk1	PROPN
ecletica-510	156	12	and	and	CCONJ
ecletica-510	156	13	roscovitine	roscovitine	NOUN
ecletica-510	156	14	,	,	PUNCT
ecletica-510	156	15	in	in	ADP
ecletica-510	156	16	the	the	DET
ecletica-510	156	17	binary	binary	PROPN
ecletica-510	156	18	model	model	NOUN
ecletica-510	156	19	,	,	PUNCT
ecletica-510	156	20	involving	involve	VERB
ecletica-510	156	21	the	the	DET
ecletica-510	156	22	residues	residue	NOUN
ecletica-510	156	23	leu83	leu83	PROPN
ecletica-510	156	24	,	,	PUNCT
ecletica-510	156	25	asp86	asp86	NOUN
ecletica-510	156	26	,	,	PUNCT
ecletica-510	156	27	and	and	CCONJ
ecletica-510	156	28	gln132	gln132	PROPN
ecletica-510	156	29	.	.	PROPN
ecletica-510	157	1	for	for	ADP
ecletica-510	157	2	the	the	DET
ecletica-510	157	3	cdk2	cdk2	PROPN
ecletica-510	157	4	:	:	PUNCT
ecletica-510	157	5	roscovitine	roscovitine	PROPN
ecletica-510	157	6	model	model	NOUN
ecletica-510	157	7	only	only	ADV
ecletica-510	157	8	two	two	NUM
ecletica-510	157	9	hydrogen	hydrogen	NOUN
ecletica-510	157	10	bonds	bond	NOUN
ecletica-510	157	11	,	,	PUNCT
ecletica-510	157	12	involving	involve	VERB
ecletica-510	157	13	the	the	DET
ecletica-510	157	14	residue	residue	NOUN
ecletica-510	157	15	leu83	leu83	NOUN
ecletica-510	157	16	,	,	PUNCT
ecletica-510	157	17	were	be	AUX
ecletica-510	157	18	observed	observe	VERB
ecletica-510	157	19	.	.	PUNCT
ecletica-510	158	1	table	table	NOUN
ecletica-510	158	2	7	7	NUM
ecletica-510	158	3	shows	show	VERB
ecletica-510	158	4	the	the	DET
ecletica-510	158	5	intermolecular	intermolecular	ADJ
ecletica-510	158	6	hydrogen	hydrogen	NOUN
ecletica-510	158	7	bonds	bond	NOUN
ecletica-510	158	8	for	for	ADP
ecletica-510	158	9	cdk1	cdk1	PROPN
ecletica-510	158	10	:	:	PUNCT
ecletica-510	158	11	roscovitine	roscovitine	PROPN
ecletica-510	158	12	complex	complex	NOUN
ecletica-510	158	13	.	.	PUNCT
ecletica-510	159	1	as	as	SCONJ
ecletica-510	159	2	observed	observe	VERB
ecletica-510	159	3	in	in	ADP
ecletica-510	159	4	the	the	DET
ecletica-510	159	5	crystallographic	crystallographic	ADJ
ecletica-510	159	6	structure	structure	NOUN
ecletica-510	159	7	of	of	ADP
ecletica-510	159	8	cdk2	cdk2	PROPN
ecletica-510	159	9	:	:	PUNCT
ecletica-510	159	10	roscovitine	roscovitine	VERB
ecletica-510	160	1	[	[	X
ecletica-510	160	2	16	16	NUM
ecletica-510	160	3	]	]	PUNCT
ecletica-510	160	4	,	,	PUNCT
ecletica-510	160	5	and	and	CCONJ
ecletica-510	160	6	for	for	ADP
ecletica-510	160	7	the	the	DET
ecletica-510	160	8	cdk2	cdk2	PROPN
ecletica-510	160	9	:	:	PUNCT
ecletica-510	160	10	flavopiridol	flavopiridol	PROPN
ecletica-510	160	11	model	model	NOUN
ecletica-510	160	12	[	[	X
ecletica-510	160	13	17	17	NUM
ecletica-510	160	14	]	]	PUNCT
ecletica-510	160	15	the	the	DET
ecletica-510	160	16	region	region	NOUN
ecletica-510	160	17	of	of	ADP
ecletica-510	160	18	cdk1	cdk1	PROPN
ecletica-510	160	19	occupied	occupy	VERB
ecletica-510	160	20	by	by	ADP
ecletica-510	160	21	the	the	DET
ecletica-510	160	22	phenyl	phenyl	NOUN
ecletica-510	160	23	ring	ring	NOUN
ecletica-510	160	24	of	of	ADP
ecletica-510	160	25	roscovitine	roscovitine	NOUN
ecletica-510	160	26	and	and	CCONJ
ecletica-510	160	27	the	the	DET
ecletica-510	160	28	chlorophenyl	chlorophenyl	NOUN
ecletica-510	160	29	of	of	ADP
ecletica-510	160	30	flavopiridol	flavopiridol	PROPN
ecletica-510	160	31	is	be	AUX
ecletica-510	160	32	pointing	point	VERB
ecletica-510	160	33	away	away	ADV
ecletica-510	160	34	from	from	ADP
ecletica-510	160	35	the	the	DET
ecletica-510	160	36	atp	atp	NOUN
ecletica-510	160	37	-	-	PUNCT
ecletica-510	160	38	binding	bind	VERB
ecletica-510	160	39	pocket	pocket	NOUN
ecletica-510	160	40	,	,	PUNCT
ecletica-510	160	41	and	and	CCONJ
ecletica-510	160	42	partially	partially	ADV
ecletica-510	160	43	exposed	expose	VERB
ecletica-510	160	44	to	to	ADP
ecletica-510	160	45	solvent	solvent	NOUN
ecletica-510	160	46	in	in	ADP
ecletica-510	160	47	both	both	DET
ecletica-510	160	48	complexes	complex	NOUN
ecletica-510	160	49	.	.	PUNCT
ecletica-510	161	1	table	table	NOUN
ecletica-510	161	2	6	6	NUM
ecletica-510	161	3	:	:	PUNCT
ecletica-510	161	4	intermolecular	intermolecular	ADJ
ecletica-510	161	5	hydrogen	hydrogen	NOUN
ecletica-510	161	6	bonds	bond	NOUN
ecletica-510	161	7	between	between	ADP
ecletica-510	161	8	cdk1	cdk1	PROPN
ecletica-510	161	9	and	and	CCONJ
ecletica-510	161	10	flavopiridol	flavopiridol	NOUN
ecletica-510	161	11	.	.	PUNCT
ecletica-510	161	12	table	table	NOUN
ecletica-510	161	13	7	7	NUM
ecletica-510	161	14	:	:	PUNCT
ecletica-510	161	15	intermolecular	intermolecular	ADJ
ecletica-510	161	16	hydrogen	hydrogen	NOUN
ecletica-510	161	17	bonds	bond	NOUN
ecletica-510	161	18	between	between	ADP
ecletica-510	161	19	cdk1	cdk1	NOUN
ecletica-510	161	20	and	and	CCONJ
ecletica-510	161	21	roscovitine	roscovitine	NOUN
ecletica-510	161	22	.	.	PUNCT
ecletica-510	162	1	conclusions	conclusion	NOUN
ecletica-510	162	2	the	the	DET
ecletica-510	162	3	overall	overall	ADJ
ecletica-510	162	4	structure	structure	NOUN
ecletica-510	162	5	of	of	ADP
ecletica-510	162	6	all	all	DET
ecletica-510	162	7	complexes	complex	NOUN
ecletica-510	162	8	indicates	indicate	VERB
ecletica-510	162	9	that	that	SCONJ
ecletica-510	162	10	roscovitine	roscovitine	NOUN
ecletica-510	162	11	and	and	CCONJ
ecletica-510	162	12	flavopiridol	flavopiridol	NOUN
ecletica-510	162	13	are	be	AUX
ecletica-510	162	14	tightly	tightly	ADV
ecletica-510	162	15	bound	bind	VERB
ecletica-510	162	16	to	to	ADP
ecletica-510	162	17	the	the	DET
ecletica-510	162	18	atp	atp	NOUN
ecletica-510	162	19	-	-	PUNCT
ecletica-510	162	20	binding	bind	VERB
ecletica-510	162	21	pocket	pocket	NOUN
ecletica-510	162	22	,	,	PUNCT
ecletica-510	162	23	and	and	CCONJ
ecletica-510	162	24	no	no	DET
ecletica-510	162	25	further	far	ADV
ecletica-510	162	26	binding	bind	VERB
ecletica-510	162	27	sites	site	NOUN
ecletica-510	162	28	were	be	AUX
ecletica-510	162	29	identified	identify	VERB
ecletica-510	162	30	in	in	ADP
ecletica-510	162	31	the	the	DET
ecletica-510	162	32	cdk	cdk	NOUN
ecletica-510	162	33	structures	structure	NOUN
ecletica-510	162	34	.	.	PUNCT
ecletica-510	163	1	the	the	DET
ecletica-510	163	2	analysis	analysis	NOUN
ecletica-510	163	3	of	of	ADP
ecletica-510	163	4	the	the	DET
ecletica-510	163	5	structural	structural	ADJ
ecletica-510	163	6	models	model	NOUN
ecletica-510	163	7	and	and	CCONJ
ecletica-510	163	8	activity	activity	NOUN
ecletica-510	163	9	experiments	experiment	NOUN
ecletica-510	163	10	strongly	strongly	ADV
ecletica-510	163	11	indicates	indicate	VERB
ecletica-510	163	12	that	that	SCONJ
ecletica-510	163	13	the	the	DET
ecletica-510	163	14	comparison	comparison	NOUN
ecletica-510	163	15	of	of	ADP
ecletica-510	163	16	structures	structure	NOUN
ecletica-510	163	17	of	of	ADP
ecletica-510	163	18	different	different	ADJ
ecletica-510	163	19	enzymes	enzyme	NOUN
ecletica-510	163	20	complexed	complexe	VERB
ecletica-510	163	21	with	with	ADP
ecletica-510	163	22	same	same	ADJ
ecletica-510	163	23	inhibitor	inhibitor	NOUN
ecletica-510	163	24	(	(	PUNCT
ecletica-510	163	25	roscovitine	roscovitine	NOUN
ecletica-510	163	26	complexed	complexe	VERB
ecletica-510	163	27	with	with	ADP
ecletica-510	163	28	cdk1	cdk1	PROPN
ecletica-510	163	29	and	and	CCONJ
ecletica-510	163	30	cdk2	cdk2	PROPN
ecletica-510	163	31	,	,	PUNCT
ecletica-510	163	32	and	and	CCONJ
ecletica-510	163	33	flavopiridol	flavopiridol	NOUN
ecletica-510	163	34	complexed	complexe	VERB
ecletica-510	163	35	with	with	ADP
ecletica-510	163	36	cdk1	cdk1	PROPN
ecletica-510	163	37	and	and	CCONJ
ecletica-510	163	38	cdk2	cdk2	PROPN
ecletica-510	163	39	)	)	PUNCT
ecletica-510	163	40	can	can	AUX
ecletica-510	163	41	be	be	AUX
ecletica-510	163	42	used	use	VERB
ecletica-510	163	43	for	for	ADP
ecletica-510	163	44	a	a	DET
ecletica-510	163	45	qualitative	qualitative	ADJ
ecletica-510	163	46	analysis	analysis	NOUN
ecletica-510	163	47	of	of	ADP
ecletica-510	163	48	the	the	DET
ecletica-510	163	49	activity	activity	NOUN
ecletica-510	163	50	of	of	ADP
ecletica-510	163	51	these	these	DET
ecletica-510	163	52	inhibitors	inhibitor	NOUN
ecletica-510	163	53	against	against	ADP
ecletica-510	163	54	different	different	ADJ
ecletica-510	163	55	enzymes	enzyme	NOUN
ecletica-510	163	56	.	.	PUNCT
ecletica-510	164	1	furthermore	furthermore	ADV
ecletica-510	164	2	,	,	PUNCT
ecletica-510	164	3	the	the	DET
ecletica-510	164	4	molecular	molecular	ADJ
ecletica-510	164	5	fork	fork	NOUN
ecletica-510	164	6	identified	identify	VERB
ecletica-510	164	7	in	in	ADP
ecletica-510	164	8	cdk2	cdk2	PROPN
ecletica-510	164	9	structures	structure	NOUN
ecletica-510	164	10	seems	seem	VERB
ecletica-510	164	11	to	to	PART
ecletica-510	164	12	be	be	AUX
ecletica-510	164	13	conserved	conserve	VERB
ecletica-510	164	14	in	in	ADP
ecletica-510	164	15	the	the	DET
ecletica-510	164	16	cdk1	cdk1	PROPN
ecletica-510	164	17	,	,	PUNCT
ecletica-510	164	18	cdk5	cdk5	PROPN
ecletica-510	164	19	and	and	CCONJ
ecletica-510	164	20	cdk9	cdk9	NOUN
ecletica-510	164	21	models	model	NOUN
ecletica-510	164	22	,	,	PUNCT
ecletica-510	164	23	and	and	CCONJ
ecletica-510	164	24	being	be	AUX
ecletica-510	164	25	also	also	ADV
ecletica-510	164	26	involved	involve	VERB
ecletica-510	164	27	in	in	ADP
ecletica-510	164	28	hydrogen	hydrogen	NOUN
ecletica-510	164	29	bonds	bond	NOUN
ecletica-510	164	30	with	with	ADP
ecletica-510	164	31	the	the	DET
ecletica-510	164	32	inhibitors	inhibitor	NOUN
ecletica-510	164	33	,	,	PUNCT
ecletica-510	164	34	this	this	PRON
ecletica-510	164	35	suggests	suggest	VERB
ecletica-510	164	36	that	that	SCONJ
ecletica-510	164	37	cdk1	cdk1	PROPN
ecletica-510	164	38	,	,	PUNCT
ecletica-510	164	39	5	5	NUM
ecletica-510	164	40	,	,	PUNCT
ecletica-510	164	41	and	and	CCONJ
ecletica-510	164	42	9	9	NUM
ecletica-510	164	43	may	may	AUX
ecletica-510	164	44	also	also	ADV
ecletica-510	164	45	be	be	AUX
ecletica-510	164	46	strongly	strongly	ADV
ecletica-510	164	47	inhibited	inhibit	VERB
ecletica-510	164	48	by	by	ADP
ecletica-510	164	49	other	other	ADJ
ecletica-510	164	50	cdk2	cdk2	PROPN
ecletica-510	164	51	inhibitors	inhibitor	NOUN
ecletica-510	164	52	.	.	PUNCT
ecletica-510	165	1	further	far	ADV
ecletica-510	165	2	inhibition	inhibition	NOUN
ecletica-510	165	3	experiments	experiment	NOUN
ecletica-510	165	4	may	may	AUX
ecletica-510	165	5	confirm	confirm	VERB
ecletica-510	165	6	this	this	DET
ecletica-510	165	7	prediction	prediction	NOUN
ecletica-510	165	8	.	.	PUNCT
ecletica-510	166	1	acknowledgments	acknowledgment	NOUN
ecletica-510	166	2	this	this	DET
ecletica-510	166	3	work	work	NOUN
ecletica-510	166	4	was	be	AUX
ecletica-510	166	5	supported	support	VERB
ecletica-510	166	6	by	by	ADP
ecletica-510	166	7	grants	grant	NOUN
ecletica-510	166	8	from	from	ADP
ecletica-510	166	9	fapesp	fapesp	ADJ
ecletica-510	166	10	(	(	PUNCT
ecletica-510	166	11	smolbnet	smolbnet	NOUN
ecletica-510	166	12	–	–	PUNCT
ecletica-510	166	13	proc	proc	NOUN
ecletica-510	166	14	.	.	PUNCT
ecletica-510	167	1	n.	n.	NOUN
ecletica-510	167	2	01/07532	01/07532	PROPN
ecletica-510	167	3	-	-	PUNCT
ecletica-510	167	4	0	0	NUM
ecletica-510	167	5	)	)	PUNCT
ecletica-510	167	6	,	,	PUNCT
ecletica-510	167	7	cnpq	cnpq	NOUN
ecletica-510	167	8	,	,	PUNCT
ecletica-510	167	9	and	and	CCONJ
ecletica-510	167	10	capes	cape	NOUN
ecletica-510	167	11	.	.	PUNCT
ecletica-510	168	1	wfajr	wfajr	PROPN
ecletica-510	168	2	.	.	PUNCT
ecletica-510	169	1	is	be	AUX
ecletica-510	169	2	a	a	DET
ecletica-510	169	3	researcher	researcher	NOUN
ecletica-510	169	4	for	for	ADP
ecletica-510	169	5	the	the	DET
ecletica-510	169	6	brazilian	brazilian	ADJ
ecletica-510	169	7	council	council	NOUN
ecletica-510	169	8	for	for	ADP
ecletica-510	169	9	scientific	scientific	ADJ
ecletica-510	169	10	and	and	CCONJ
ecletica-510	169	11	technological	technological	ADJ
ecletica-510	169	12	development	development	NOUN
ecletica-510	169	13	(	(	PUNCT
ecletica-510	169	14	cnpq	cnpq	NOUN
ecletica-510	169	15	,	,	PUNCT
ecletica-510	169	16	300851/98	300851/98	NUM
ecletica-510	169	17	-	-	SYM
ecletica-510	169	18	7	7	NUM
ecletica-510	169	19	)	)	PUNCT
ecletica-510	169	20	.	.	PUNCT
ecletica-510	170	1	canduri	canduri	PROPN
ecletica-510	170	2	,	,	PUNCT
ecletica-510	170	3	f.	f.	PROPN
ecletica-510	170	4	;	;	PUNCT
ecletica-510	170	5	silveira	silveira	PROPN
ecletica-510	170	6	,	,	PUNCT
ecletica-510	170	7	n.	n.	PROPN
ecletica-510	170	8	j.	j.	PROPN
ecletica-510	170	9	f.	f.	PROPN
ecletica-510	170	10	da	da	PROPN
ecletica-510	170	11	;	;	PUNCT
ecletica-510	170	12	camera	camera	PROPN
ecletica-510	170	13	jr	jr	PROPN
ecletica-510	170	14	,	,	PUNCT
ecletica-510	170	15	j.	j.	PROPN
ecletica-510	170	16	c.	c.	PROPN
ecletica-510	170	17	;	;	PUNCT
ecletica-510	170	18	azevedo	azevedo	PROPN
ecletica-510	170	19	jr	jr	PROPN
ecletica-510	170	20	,	,	PUNCT
ecletica-510	170	21	w.	w.	PROPN
ecletica-510	170	22	f.	f.	PROPN
ecletica-510	170	23	de.estudo	de.estudo	PROPN
ecletica-510	170	24	de	de	PROPN
ecletica-510	170	25	bioinformática	bioinformática	PROPN
ecletica-510	170	26	estrutural	estrutural	PROPN
ecletica-510	170	27	de	de	PROPN
ecletica-510	170	28	quinases	quinases	PROPN
ecletica-510	170	29	dependentes	dependente	VERB
ecletica-510	170	30	de	de	ADP
ecletica-510	170	31	ciclinas	ciclina	NOUN
ecletica-510	170	32	complexadas	complexadas	PROPN
ecletica-510	170	33	com	com	NOUN
ecletica-510	170	34	inibidores	inibidore	NOUN
ecletica-510	170	35	.	.	PUNCT
ecletica-510	171	1	resumo	resumo	ADJ
ecletica-510	171	2	o	o	PROPN
ecletica-510	171	3	presente	presente	PROPN
ecletica-510	171	4	trabalho	trabalho	PROPN
ecletica-510	171	5	descreve	descreve	NOUN
ecletica-510	171	6	modelos	modelos	PROPN
ecletica-510	171	7	moleculares	moleculares	PROPN
ecletica-510	171	8	para	para	PROPN
ecletica-510	171	9	os	os	PROPN
ecletica-510	171	10	complexos	complexos	PROPN
ecletica-510	171	11	binários	binários	PROPN
ecletica-510	171	12	cdk9	cdk9	PROPN
ecletica-510	171	13	,	,	PUNCT
ecletica-510	171	14	cdk5	cdk5	PROPN
ecletica-510	171	15	e	e	PROPN
ecletica-510	171	16	cdk1	cdk1	PROPN
ecletica-510	171	17	complexados	complexado	NOUN
ecletica-510	171	18	com	com	VERB
ecletica-510	171	19	flavopiridol	flavopiridol	VERB
ecletica-510	171	20	e	e	PROPN
ecletica-510	171	21	roscovitina	roscovitina	NOUN
ecletica-510	171	22	.	.	PUNCT
ecletica-510	172	1	esses	esse	NOUN
ecletica-510	172	2	modelos	modelos	PROPN
ecletica-510	172	3	estruturais	estruturais	PROPN
ecletica-510	172	4	indicam	indicam	PROPN
ecletica-510	172	5	que	que	PROPN
ecletica-510	172	6	os	os	PROPN
ecletica-510	172	7	inibidores	inibidores	PROPN
ecletica-510	172	8	ligam	ligam	PROPN
ecletica-510	172	9	-	-	PUNCT
ecletica-510	172	10	se	se	X
ecletica-510	172	11	fortemente	fortemente	PROPN
ecletica-510	172	12	ao	ao	PROPN
ecletica-510	172	13	sítio	sítio	PROPN
ecletica-510	172	14	de	de	PROPN
ecletica-510	172	15	ligação	ligação	PROPN
ecletica-510	172	16	de	de	PROPN
ecletica-510	172	17	atp	atp	PROPN
ecletica-510	172	18	das	das	PROPN
ecletica-510	172	19	cdks	cdks	PROPN
ecletica-510	172	20	e	e	PROPN
ecletica-510	172	21	comparações	comparações	PROPN
ecletica-510	172	22	estruturais	estruturais	PROPN
ecletica-510	172	23	dos	do	VERB
ecletica-510	172	24	complexos	complexos	PROPN
ecletica-510	172	25	cdk2	cdk2	PROPN
ecletica-510	172	26	-	-	PUNCT
ecletica-510	172	27	flavopiridol	flavopiridol	VERB
ecletica-510	172	28	e	e	PROPN
ecletica-510	172	29	cdk2	cdk2	PROPN
ecletica-510	172	30	-	-	PUNCT
ecletica-510	172	31	roscovitina	roscovitina	PROPN
ecletica-510	172	32	relacionam	relacionam	PROPN
ecletica-510	172	33	diferenças	diferenças	PROPN
ecletica-510	172	34	estruturais	estruturais	PROPN
ecletica-510	172	35	com	com	PROPN
ecletica-510	172	36	diferenças	diferenças	PROPN
ecletica-510	172	37	na	na	PROPN
ecletica-510	172	38	inibição	inibição	PROPN
ecletica-510	172	39	dessas	dessas	PROPN
ecletica-510	172	40	cdks	cdks	PROPN
ecletica-510	172	41	por	por	PROPN
ecletica-510	172	42	esses	esse	NOUN
ecletica-510	172	43	inibidores	inibidore	NOUN
ecletica-510	172	44	.	.	PUNCT
ecletica-510	173	1	essas	essas	PROPN
ecletica-510	173	2	estruturas	estruturas	PROPN
ecletica-510	173	3	abrem	abrem	VERB
ecletica-510	173	4	a	a	DET
ecletica-510	173	5	possibilidade	possibilidade	NOUN
ecletica-510	173	6	de	de	PROPN
ecletica-510	173	7	testar	testar	PROPN
ecletica-510	173	8	novas	novas	PROPN
ecletica-510	173	9	famílias	famílias	PROPN
ecletica-510	173	10	de	de	PROPN
ecletica-510	173	11	inibidores	inibidores	PROPN
ecletica-510	173	12	,	,	PUNCT
ecletica-510	173	13	em	em	PRON
ecletica-510	173	14	adição	adição	PROPN
ecletica-510	173	15	aos	aos	PROPN
ecletica-510	173	16	novos	novos	PROPN
ecletica-510	173	17	ecl	ecl	PROPN
ecletica-510	173	18	.	.	PROPN
ecletica-510	173	19	quím	quím	PROPN
ecletica-510	173	20	.	.	PUNCT
ecletica-510	174	1	,	,	PUNCT
ecletica-510	174	2	são	são	PROPN
ecletica-510	174	3	paulo	paulo	PROPN
ecletica-510	174	4	,	,	PUNCT
ecletica-510	174	5	28(1	28(1	NOUN
ecletica-510	174	6	):	):	PUNCT
ecletica-510	174	7	45	45	NUM
ecletica-510	174	8	-	-	SYM
ecletica-510	174	9	53	53	NUM
ecletica-510	174	10	,	,	PUNCT
ecletica-510	174	11	2003	2003	NUM
ecletica-510	174	12	52	52	NUM
ecletica-510	174	13	substituintes	substituinte	NOUN
ecletica-510	174	14	para	para	NOUN
ecletica-510	174	15	as	as	ADP
ecletica-510	174	16	estruturas	estruturas	PROPN
ecletica-510	174	17	já	já	X
ecletica-510	174	18	conhecidas	conhecida	NOUN
ecletica-510	174	19	,	,	PUNCT
ecletica-510	174	20	tais	tais	PROPN
ecletica-510	174	21	como	como	PROPN
ecletica-510	174	22	flavonas	flavonas	PROPN
ecletica-510	174	23	e	e	X
ecletica-510	174	24	derivados	derivados	X
ecletica-510	174	25	de	de	X
ecletica-510	174	26	adenina	adenina	NOUN
ecletica-510	174	27	.	.	PUNCT
ecletica-510	175	1	palavras	palavra	NOUN
ecletica-510	175	2	-	-	PUNCT
ecletica-510	175	3	chave	chave	NOUN
ecletica-510	175	4	:	:	PUNCT
ecletica-510	175	5	cdk	cdk	PROPN
ecletica-510	175	6	,	,	PUNCT
ecletica-510	175	7	flavopiridol	flavopiridol	NOUN
ecletica-510	175	8	,	,	PUNCT
ecletica-510	175	9	bio	bio	PROPN
ecletica-510	175	10	-	-	PUNCT
ecletica-510	175	11	informática	informática	PROPN
ecletica-510	175	12	,	,	PUNCT
ecletica-510	175	13	estrutura	estrutura	NOUN
ecletica-510	175	14	,	,	PUNCT
ecletica-510	175	15	desenho	desenho	PROPN
ecletica-510	175	16	de	de	X
ecletica-510	175	17	drogas	drogas	PROPN
ecletica-510	175	18	.	.	PUNCT
ecletica-510	176	1	references	reference	NOUN
ecletica-510	176	2	[	[	X
ecletica-510	176	3	1	1	NUM
ecletica-510	176	4	]	]	X
ecletica-510	176	5	alvarez	alvarez	PROPN
ecletica-510	176	6	,	,	PUNCT
ecletica-510	176	7	a.	a.	PROPN
ecletica-510	176	8	;	;	PUNCT
ecletica-510	176	9	toro	toro	PROPN
ecletica-510	176	10	,	,	PUNCT
ecletica-510	176	11	r.	r.	PROPN
ecletica-510	176	12	;	;	PUNCT
ecletica-510	176	13	cáceres	cácere	NOUN
ecletica-510	176	14	,	,	PUNCT
ecletica-510	176	15	a.	a.	NOUN
ecletica-510	176	16	;	;	PUNCT
ecletica-510	176	17	maccioni	maccioni	PROPN
ecletica-510	176	18	,	,	PUNCT
ecletica-510	176	19	r.	r.	PROPN
ecletica-510	176	20	b.	b.	PROPN
ecletica-510	176	21	inhibition	inhibition	NOUN
ecletica-510	176	22	of	of	ADP
ecletica-510	176	23	tau	tau	PROPN
ecletica-510	176	24	phosphorylating	phosphorylate	VERB
ecletica-510	176	25	protein	protein	NOUN
ecletica-510	176	26	kinase	kinase	PROPN
ecletica-510	176	27	cdk5	cdk5	PROPN
ecletica-510	176	28	prevents	prevent	VERB
ecletica-510	176	29	beta	beta	NOUN
ecletica-510	176	30	-	-	PUNCT
ecletica-510	176	31	amyloid	amyloid	NOUN
ecletica-510	176	32	-	-	PUNCT
ecletica-510	176	33	induced	induce	VERB
ecletica-510	176	34	neuronal	neuronal	ADJ
ecletica-510	176	35	death	death	NOUN
ecletica-510	176	36	.	.	PUNCT
ecletica-510	177	1	febs	febs	PROPN
ecletica-510	177	2	lett	lett	PROPN
ecletica-510	177	3	,	,	PUNCT
ecletica-510	177	4	v.	v.	ADP
ecletica-510	177	5	459	459	NUM
ecletica-510	177	6	,	,	PUNCT
ecletica-510	177	7	n.	n.	NOUN
ecletica-510	177	8	3	3	NUM
ecletica-510	177	9	,	,	PUNCT
ecletica-510	177	10	p.	p.	NOUN
ecletica-510	177	11	421	421	NUM
ecletica-510	177	12	-	-	SYM
ecletica-510	177	13	426	426	NUM
ecletica-510	177	14	,	,	PUNCT
ecletica-510	177	15	1999	1999	NUM
ecletica-510	177	16	.	.	PUNCT
ecletica-510	178	1	[	[	X
ecletica-510	178	2	2	2	NUM
ecletica-510	178	3	]	]	PUNCT
ecletica-510	178	4	arris	arris	PROPN
ecletica-510	178	5	,	,	PUNCT
ecletica-510	178	6	c.	c.	PROPN
ecletica-510	178	7	e.	e.	PROPN
ecletica-510	178	8	;	;	PUNCT
ecletica-510	178	9	boyle	boyle	PROPN
ecletica-510	178	10	,	,	PUNCT
ecletica-510	178	11	f.	f.	PROPN
ecletica-510	178	12	t.	t.	PROPN
ecletica-510	178	13	;	;	PUNCT
ecletica-510	178	14	calvert	calvert	PROPN
ecletica-510	178	15	,	,	PUNCT
ecletica-510	178	16	a.	a.	PROPN
ecletica-510	178	17	h.	h.	PROPN
ecletica-510	178	18	;	;	PUNCT
ecletica-510	178	19	curtin	curtin	PROPN
ecletica-510	178	20	,	,	PUNCT
ecletica-510	178	21	n.	n.	PROPN
ecletica-510	178	22	j.	j.	PROPN
ecletica-510	178	23	;	;	PUNCT
ecletica-510	178	24	endicott	endicott	PROPN
ecletica-510	178	25	,	,	PUNCT
ecletica-510	178	26	j.	j.	PROPN
ecletica-510	178	27	a.	a.	PROPN
ecletica-510	178	28	;	;	PUNCT
ecletica-510	178	29	garman	garman	PROPN
ecletica-510	178	30	,	,	PUNCT
ecletica-510	178	31	e.	e.	PROPN
ecletica-510	178	32	f.	f.	PROPN
ecletica-510	178	33	;	;	PUNCT
ecletica-510	178	34	gibson	gibson	PROPN
ecletica-510	178	35	,	,	PUNCT
ecletica-510	178	36	a.	a.	PROPN
ecletica-510	178	37	e.	e.	PROPN
ecletica-510	178	38	;	;	PUNCT
ecletica-510	178	39	golding	golding	PROPN
ecletica-510	178	40	,	,	PUNCT
ecletica-510	178	41	b.	b.	PROPN
ecletica-510	178	42	t.	t.	PROPN
ecletica-510	178	43	;	;	PUNCT
ecletica-510	178	44	grant	grant	PROPN
ecletica-510	178	45	,	,	PUNCT
ecletica-510	178	46	s.	s.	PROPN
ecletica-510	178	47	;	;	PUNCT
ecletica-510	178	48	griffin	griffin	PROPN
ecletica-510	178	49	,	,	PUNCT
ecletica-510	178	50	r.	r.	PROPN
ecletica-510	178	51	j.	j.	PROPN
ecletica-510	178	52	;	;	PUNCT
ecletica-510	178	53	jewsbury	jewsbury	PROPN
ecletica-510	178	54	,	,	PUNCT
ecletica-510	178	55	p.	p.	PROPN
ecletica-510	178	56	;	;	PUNCT
ecletica-510	178	57	johnson	johnson	PROPN
ecletica-510	178	58	,	,	PUNCT
ecletica-510	178	59	l.	l.	PROPN
ecletica-510	178	60	n.	n.	PROPN
ecletica-510	178	61	;	;	PUNCT
ecletica-510	178	62	lawrie	lawrie	PROPN
ecletica-510	178	63	,	,	PUNCT
ecletica-510	178	64	a.	a.	NOUN
ecletica-510	178	65	m.	m.	NOUN
ecletica-510	178	66	;	;	PUNCT
ecletica-510	178	67	newell	newell	PROPN
ecletica-510	178	68	,	,	PUNCT
ecletica-510	178	69	d.	d.	PROPN
ecletica-510	178	70	r.	r.	PROPN
ecletica-510	178	71	;	;	PUNCT
ecletica-510	178	72	noble	noble	ADJ
ecletica-510	178	73	,	,	PUNCT
ecletica-510	178	74	m.	m.	NOUN
ecletica-510	178	75	e.	e.	PROPN
ecletica-510	178	76	;	;	PUNCT
ecletica-510	178	77	sausville	sausville	PROPN
ecletica-510	178	78	,	,	PUNCT
ecletica-510	178	79	e.	e.	PROPN
ecletica-510	178	80	a.	a.	PROPN
ecletica-510	178	81	;	;	PUNCT
ecletica-510	178	82	schultz	schultz	PROPN
ecletica-510	178	83	,	,	PUNCT
ecletica-510	178	84	r.	r.	PROPN
ecletica-510	178	85	;	;	PUNCT
ecletica-510	178	86	yu	yu	PROPN
ecletica-510	178	87	,	,	PUNCT
ecletica-510	178	88	w.	w.	NOUN
ecletica-510	178	89	identification	identification	NOUN
ecletica-510	178	90	of	of	ADP
ecletica-510	178	91	novel	novel	ADJ
ecletica-510	178	92	purine	purine	NOUN
ecletica-510	178	93	and	and	CCONJ
ecletica-510	178	94	pyrimidine	pyrimidine	NOUN
ecletica-510	178	95	cyclin	cyclin	NOUN
ecletica-510	178	96	-	-	PUNCT
ecletica-510	178	97	dependent	dependent	ADJ
ecletica-510	178	98	kinase	kinase	NOUN
ecletica-510	178	99	inhibitors	inhibitor	NOUN
ecletica-510	178	100	with	with	ADP
ecletica-510	178	101	distinct	distinct	ADJ
ecletica-510	178	102	molecular	molecular	ADJ
ecletica-510	178	103	interactions	interaction	NOUN
ecletica-510	178	104	and	and	CCONJ
ecletica-510	178	105	tumor	tumor	NOUN
ecletica-510	178	106	cell	cell	NOUN
ecletica-510	178	107	growth	growth	NOUN
ecletica-510	178	108	inhibition	inhibition	NOUN
ecletica-510	178	109	profiles	profile	NOUN
ecletica-510	178	110	.	.	PUNCT
ecletica-510	179	1	j.	j.	PROPN
ecletica-510	179	2	med	med	PROPN
ecletica-510	179	3	.	.	PROPN
ecletica-510	179	4	chem	chem	PROPN
ecletica-510	179	5	.	.	PUNCT
ecletica-510	179	6	,	,	PUNCT
ecletica-510	180	1	v.	v.	ADP
ecletica-510	180	2	43	43	NUM
ecletica-510	180	3	,	,	PUNCT
ecletica-510	180	4	n.	n.	NOUN
ecletica-510	180	5	15	15	NUM
ecletica-510	180	6	,	,	PUNCT
ecletica-510	180	7	p.	p.	NOUN
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ecletica-510	180	9	-	-	SYM
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ecletica-510	180	12	2000	2000	NUM
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ecletica-510	181	5	,	,	PUNCT
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ecletica-510	181	8	;	;	PUNCT
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ecletica-510	181	11	d.	d.	PROPN
ecletica-510	181	12	;	;	PUNCT
ecletica-510	181	13	gardner	gardner	PROPN
ecletica-510	181	14	,	,	PUNCT
ecletica-510	181	15	s.	s.	PROPN
ecletica-510	181	16	;	;	PUNCT
ecletica-510	181	17	hayes	hayes	PROPN
ecletica-510	181	18	,	,	PUNCT
ecletica-510	181	19	f.	f.	PROPN
ecletica-510	181	20	;	;	PUNCT
ecletica-510	181	21	howlin	howlin	PROPN
ecletica-510	181	22	,	,	PUNCT
ecletica-510	181	23	b.	b.	PROPN
ecletica-510	181	24	;	;	PUNCT
ecletica-510	181	25	hubbard	hubbard	PROPN
ecletica-510	181	26	,	,	PUNCT
ecletica-510	181	27	t.	t.	PROPN
ecletica-510	181	28	;	;	PUNCT
ecletica-510	181	29	overington	overington	PROPN
ecletica-510	181	30	,	,	PUNCT
ecletica-510	181	31	j.	j.	PROPN
ecletica-510	181	32	;	;	PUNCT
ecletica-510	181	33	singh	singh	PROPN
ecletica-510	181	34	,	,	PUNCT
ecletica-510	181	35	d.	d.	PROPN
ecletica-510	181	36	a.	a.	PROPN
ecletica-510	181	37	;	;	PUNCT
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ecletica-510	181	39	,	,	PUNCT
ecletica-510	181	40	b.	b.	PROPN
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ecletica-510	181	42	;	;	PUNCT
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ecletica-510	181	44	,	,	PUNCT
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ecletica-510	181	46	18th	18th	ADJ
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ecletica-510	181	48	,	,	PUNCT
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ecletica-510	181	59	.	.	PUNCT
ecletica-510	182	1	eur	eur	PROPN
ecletica-510	182	2	.	.	PUNCT
ecletica-510	183	1	j.	j.	PROPN
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ecletica-510	183	3	.	.	PUNCT
ecletica-510	183	4	,	,	PUNCT
ecletica-510	184	1	v.	v.	ADP
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ecletica-510	184	3	,	,	PUNCT
ecletica-510	184	4	n.	n.	NOUN
ecletica-510	184	5	3	3	NUM
ecletica-510	184	6	,	,	PUNCT
ecletica-510	184	7	p.	p.	NOUN
ecletica-510	184	8	513	513	NUM
ecletica-510	184	9	-	-	SYM
ecletica-510	184	10	520	520	NUM
ecletica-510	184	11	,	,	PUNCT
ecletica-510	184	12	1988	1988	NUM
ecletica-510	184	13	.	.	PUNCT
ecletica-510	185	1	[	[	X
ecletica-510	185	2	4	4	NUM
ecletica-510	185	3	]	]	X
ecletica-510	185	4	blundell	blundell	PROPN
ecletica-510	185	5	,	,	PUNCT
ecletica-510	185	6	t.	t.	PROPN
ecletica-510	185	7	l.	l.	PROPN
ecletica-510	185	8	;	;	PUNCT
ecletica-510	185	9	sibanda	sibanda	PROPN
ecletica-510	185	10	,	,	PUNCT
ecletica-510	185	11	b.	b.	PROPN
ecletica-510	185	12	l.	l.	PROPN
ecletica-510	185	13	;	;	PUNCT
ecletica-510	185	14	sternberg	sternberg	PROPN
ecletica-510	185	15	,	,	PUNCT
ecletica-510	185	16	m.	m.	PROPN
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ecletica-510	185	18	;	;	PUNCT
ecletica-510	185	19	thornton	thornton	PROPN
ecletica-510	185	20	,	,	PUNCT
ecletica-510	185	21	j.	j.	PROPN
ecletica-510	185	22	m.	m.	PROPN
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ecletica-510	185	24	-	-	PUNCT
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ecletica-510	185	26	prediction	prediction	NOUN
ecletica-510	185	27	of	of	ADP
ecletica-510	185	28	protein	protein	NOUN
ecletica-510	185	29	structures	structure	NOUN
ecletica-510	185	30	and	and	CCONJ
ecletica-510	185	31	the	the	DET
ecletica-510	185	32	design	design	NOUN
ecletica-510	185	33	of	of	ADP
ecletica-510	185	34	novel	novel	ADJ
ecletica-510	185	35	molecules	molecule	NOUN
ecletica-510	185	36	.	.	PUNCT
ecletica-510	186	1	nature	nature	NOUN
ecletica-510	186	2	,	,	PUNCT
ecletica-510	186	3	v.	v.	ADP
ecletica-510	186	4	326	326	NUM
ecletica-510	186	5	,	,	PUNCT
ecletica-510	186	6	n.	n.	NOUN
ecletica-510	186	7	6111	6111	NUM
ecletica-510	186	8	,	,	PUNCT
ecletica-510	186	9	p.	p.	NOUN
ecletica-510	186	10	347	347	NUM
ecletica-510	186	11	-	-	SYM
ecletica-510	186	12	352	352	NUM
ecletica-510	186	13	,	,	PUNCT
ecletica-510	186	14	1987	1987	NUM
ecletica-510	186	15	.	.	PUNCT
ecletica-510	187	1	[	[	X
ecletica-510	187	2	5	5	NUM
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ecletica-510	187	7	;	;	PUNCT
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ecletica-510	187	9	,	,	PUNCT
ecletica-510	187	10	n.	n.	NOUN
ecletica-510	187	11	calculation	calculation	NOUN
ecletica-510	187	12	of	of	ADP
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ecletica-510	187	14	conformations	conformation	NOUN
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ecletica-510	187	17	-	-	PUNCT
ecletica-510	187	18	proton	proton	NOUN
ecletica-510	187	19	distance	distance	NOUN
ecletica-510	187	20	constraints	constraint	NOUN
ecletica-510	187	21	.	.	PUNCT
ecletica-510	188	1	a	a	DET
ecletica-510	188	2	new	new	ADJ
ecletica-510	188	3	efficient	efficient	ADJ
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ecletica-510	188	5	.	.	PUNCT
ecletica-510	189	1	j.	j.	PROPN
ecletica-510	189	2	mol	mol	PROPN
ecletica-510	189	3	.	.	PUNCT
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ecletica-510	190	2	.	.	PUNCT
ecletica-510	190	3	,	,	PUNCT
ecletica-510	190	4	v.	v.	ADP
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ecletica-510	190	7	n.	n.	NOUN
ecletica-510	190	8	3	3	NUM
ecletica-510	190	9	,	,	PUNCT
ecletica-510	190	10	p.	p.	NOUN
ecletica-510	190	11	611	611	NUM
ecletica-510	190	12	-	-	SYM
ecletica-510	190	13	626	626	NUM
ecletica-510	190	14	,	,	PUNCT
ecletica-510	190	15	1985	1985	NUM
ecletica-510	190	16	.	.	PUNCT
ecletica-510	191	1	[	[	X
ecletica-510	191	2	6	6	NUM
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ecletica-510	191	5	,	,	PUNCT
ecletica-510	191	6	b.	b.	PROPN
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ecletica-510	191	8	;	;	PUNCT
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ecletica-510	191	10	,	,	PUNCT
ecletica-510	191	11	r.	r.	PROPN
ecletica-510	191	12	e.	e.	PROPN
ecletica-510	191	13	;	;	PUNCT
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ecletica-510	191	15	,	,	PUNCT
ecletica-510	191	16	b.	b.	PROPN
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ecletica-510	191	18	;	;	PUNCT
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ecletica-510	191	20	,	,	PUNCT
ecletica-510	191	21	d.	d.	PROPN
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ecletica-510	191	23	;	;	PUNCT
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ecletica-510	191	25	,	,	PUNCT
ecletica-510	191	26	s.	s.	PROPN
ecletica-510	191	27	;	;	PUNCT
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ecletica-510	191	29	,	,	PUNCT
ecletica-510	191	30	m.	m.	NOUN
ecletica-510	191	31	charmm	charmm	NOUN
ecletica-510	191	32	:	:	PUNCT
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ecletica-510	191	35	for	for	ADP
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ecletica-510	191	37	energy	energy	NOUN
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ecletica-510	191	42	.	.	PUNCT
ecletica-510	192	1	j.	j.	PROPN
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ecletica-510	192	3	.	.	PUNCT
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ecletica-510	193	2	.	.	PUNCT
ecletica-510	193	3	,	,	PUNCT
ecletica-510	194	1	v.	v.	ADP
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ecletica-510	194	3	,	,	PUNCT
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ecletica-510	194	8	,	,	PUNCT
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ecletica-510	195	7	;	;	PUNCT
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ecletica-510	195	9	,	,	PUNCT
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ecletica-510	195	14	;	;	PUNCT
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ecletica-510	195	16	,	,	PUNCT
ecletica-510	195	17	c.	c.	PROPN
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ecletica-510	195	20	;	;	PUNCT
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ecletica-510	195	22	,	,	PUNCT
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ecletica-510	195	24	;	;	PUNCT
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ecletica-510	195	30	;	;	PUNCT
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ecletica-510	195	33	,	,	PUNCT
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ecletica-510	195	35	;	;	PUNCT
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ecletica-510	195	38	,	,	PUNCT
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ecletica-510	195	42	.	.	PUNCT
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ecletica-510	195	51	.	.	PUNCT
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ecletica-510	196	4	,	,	PUNCT
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ecletica-510	196	10	,	,	PUNCT
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ecletica-510	197	8	;	;	PUNCT
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ecletica-510	197	10	,	,	PUNCT
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ecletica-510	197	12	;	;	PUNCT
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ecletica-510	197	20	;	;	PUNCT
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ecletica-510	197	25	;	;	PUNCT
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ecletica-510	197	29	;	;	PUNCT
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ecletica-510	197	33	;	;	PUNCT
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ecletica-510	197	36	e.	e.	PROPN
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ecletica-510	197	38	;	;	PUNCT
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ecletica-510	197	40	,	,	PUNCT
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ecletica-510	197	59	.	.	PUNCT
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ecletica-510	198	10	-	-	SYM
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ecletica-510	198	12	,	,	PUNCT
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ecletica-510	199	5	,	,	PUNCT
ecletica-510	199	6	s.	s.	PROPN
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ecletica-510	199	8	;	;	PUNCT
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ecletica-510	199	10	,	,	PUNCT
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ecletica-510	199	12	;	;	PUNCT
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ecletica-510	199	23	,	,	PUNCT
ecletica-510	199	24	e.	e.	PROPN
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ecletica-510	199	26	;	;	PUNCT
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ecletica-510	199	45	and	and	CCONJ
ecletica-510	199	46	blocks	block	NOUN
ecletica-510	199	47	hiv-1	hiv-1	PART
ecletica-510	199	48	replication	replication	NOUN
ecletica-510	199	49	.	.	PUNCT
ecletica-510	200	1	j.	j.	PROPN
ecletica-510	200	2	biol	biol	PROPN
ecletica-510	200	3	.	.	PUNCT
ecletica-510	201	1	chem	chem	PROPN
ecletica-510	201	2	.	.	PUNCT
ecletica-510	201	3	,	,	PUNCT
ecletica-510	202	1	v.	v.	ADP
ecletica-510	202	2	275	275	NUM
ecletica-510	202	3	,	,	PUNCT
ecletica-510	202	4	n.	n.	NOUN
ecletica-510	202	5	37	37	NUM
ecletica-510	202	6	,	,	PUNCT
ecletica-510	202	7	p.	p.	NOUN
ecletica-510	202	8	28345	28345	NUM
ecletica-510	202	9	-	-	SYM
ecletica-510	202	10	28348	28348	NUM
ecletica-510	202	11	,	,	PUNCT
ecletica-510	202	12	2000	2000	NUM
ecletica-510	202	13	.	.	PUNCT
ecletica-510	203	1	[	[	X
ecletica-510	203	2	10	10	NUM
ecletica-510	203	3	]	]	SYM
ecletica-510	203	4	clare	clare	NOUN
ecletica-510	203	5	,	,	PUNCT
ecletica-510	203	6	p.	p.	NOUN
ecletica-510	203	7	m.	m.	NOUN
ecletica-510	203	8	;	;	PUNCT
ecletica-510	203	9	poorman	poorman	PROPN
ecletica-510	203	10	,	,	PUNCT
ecletica-510	203	11	r.	r.	PROPN
ecletica-510	203	12	a.	a.	PROPN
ecletica-510	203	13	;	;	PUNCT
ecletica-510	203	14	kelley	kelley	PROPN
ecletica-510	203	15	,	,	PUNCT
ecletica-510	203	16	l.	l.	PROPN
ecletica-510	203	17	c.	c.	PROPN
ecletica-510	203	18	;	;	PUNCT
ecletica-510	203	19	watenpaugh	watenpaugh	PROPN
ecletica-510	203	20	,	,	PUNCT
ecletica-510	203	21	k.	k.	PROPN
ecletica-510	203	22	d.	d.	PROPN
ecletica-510	203	23	;	;	PUNCT
ecletica-510	203	24	bannow	bannow	PROPN
ecletica-510	203	25	,	,	PUNCT
ecletica-510	203	26	c.	c.	PROPN
ecletica-510	203	27	a.	a.	NOUN
ecletica-510	203	28	;	;	PUNCT
ecletica-510	203	29	leach	leach	NOUN
ecletica-510	203	30	,	,	PUNCT
ecletica-510	203	31	k.	k.	PROPN
ecletica-510	203	32	l.	l.	PROPN
ecletica-510	204	1	the	the	DET
ecletica-510	204	2	cyclin	cyclin	NOUN
ecletica-510	204	3	-	-	PUNCT
ecletica-510	204	4	dependent	dependent	ADJ
ecletica-510	204	5	kinases	kinase	NOUN
ecletica-510	204	6	cdk2	cdk2	PROPN
ecletica-510	204	7	and	and	CCONJ
ecletica-510	204	8	cdk5	cdk5	PROPN
ecletica-510	204	9	act	act	PROPN
ecletica-510	204	10	by	by	ADP
ecletica-510	204	11	a	a	DET
ecletica-510	204	12	random	random	ADJ
ecletica-510	204	13	,	,	PUNCT
ecletica-510	204	14	anticooperative	anticooperative	ADJ
ecletica-510	204	15	kinetic	kinetic	ADJ
ecletica-510	204	16	mechanism	mechanism	NOUN
ecletica-510	204	17	.	.	PUNCT
ecletica-510	205	1	j.	j.	PROPN
ecletica-510	205	2	biol	biol	PROPN
ecletica-510	205	3	.	.	PUNCT
ecletica-510	206	1	chem	chem	PROPN
ecletica-510	206	2	.	.	PUNCT
ecletica-510	206	3	,	,	PUNCT
ecletica-510	206	4	v.	v.	ADP
ecletica-510	206	5	276	276	NUM
ecletica-510	206	6	,	,	PUNCT
ecletica-510	207	1	p.	p.	NOUN
ecletica-510	207	2	48292	48292	NUM
ecletica-510	207	3	-	-	SYM
ecletica-510	207	4	48299	48299	NUM
ecletica-510	207	5	,	,	PUNCT
ecletica-510	207	6	2001	2001	NUM
ecletica-510	207	7	.	.	PUNCT
ecletica-510	208	1	[	[	X
ecletica-510	208	2	11	11	NUM
ecletica-510	208	3	]	]	X
ecletica-510	208	4	collaborative	collaborative	ADJ
ecletica-510	208	5	computational	computational	ADJ
ecletica-510	208	6	project	project	NOUN
ecletica-510	208	7	n.	n.	NOUN
ecletica-510	208	8	4	4	NUM
ecletica-510	208	9	.	.	PUNCT
ecletica-510	209	1	the	the	DET
ecletica-510	209	2	ccp4	ccp4	NOUN
ecletica-510	209	3	suite	suite	NOUN
ecletica-510	209	4	:	:	PUNCT
ecletica-510	209	5	programs	program	NOUN
ecletica-510	209	6	for	for	ADP
ecletica-510	209	7	protein	protein	NOUN
ecletica-510	209	8	crystallography	crystallography	NOUN
ecletica-510	209	9	.	.	PUNCT
ecletica-510	210	1	acta	acta	PROPN
ecletica-510	210	2	crystallogr	crystallogr	PROPN
ecletica-510	210	3	.	.	PUNCT
ecletica-510	210	4	,	,	PUNCT
ecletica-510	211	1	v.	v.	ADP
ecletica-510	211	2	d50	d50	NOUN
ecletica-510	211	3	,	,	PUNCT
ecletica-510	211	4	p.	p.	NOUN
ecletica-510	211	5	760	760	NUM
ecletica-510	211	6	-	-	SYM
ecletica-510	211	7	763	763	NUM
ecletica-510	211	8	,	,	PUNCT
ecletica-510	211	9	1994	1994	NUM
ecletica-510	211	10	.	.	PUNCT
ecletica-510	212	1	[	[	X
ecletica-510	212	2	12	12	NUM
ecletica-510	212	3	]	]	PUNCT
ecletica-510	212	4	corpet	corpet	PROPN
ecletica-510	212	5	,	,	PUNCT
ecletica-510	212	6	f.	f.	PROPN
ecletica-510	212	7	multiple	multiple	ADJ
ecletica-510	212	8	sequence	sequence	NOUN
ecletica-510	212	9	alignment	alignment	NOUN
ecletica-510	212	10	with	with	ADP
ecletica-510	212	11	hierarchical	hierarchical	ADJ
ecletica-510	212	12	clustering	clustering	NOUN
ecletica-510	212	13	.	.	PUNCT
ecletica-510	213	1	nucl	nucl	PROPN
ecletica-510	213	2	.	.	PUNCT
ecletica-510	214	1	acids	acid	NOUN
ecletica-510	214	2	res	re	NOUN
ecletica-510	214	3	.	.	PUNCT
ecletica-510	214	4	,	,	PUNCT
ecletica-510	215	1	v.	v.	ADP
ecletica-510	215	2	16	16	NUM
ecletica-510	215	3	,	,	PUNCT
ecletica-510	215	4	n.	n.	NOUN
ecletica-510	215	5	22	22	NUM
ecletica-510	215	6	,	,	PUNCT
ecletica-510	215	7	p.10881	p.10881	NOUN
ecletica-510	215	8	-	-	PUNCT
ecletica-510	215	9	10890	10890	NUM
ecletica-510	215	10	,	,	PUNCT
ecletica-510	215	11	1988	1988	NUM
ecletica-510	215	12	.	.	PUNCT
ecletica-510	216	1	[	[	X
ecletica-510	216	2	13	13	NUM
ecletica-510	216	3	]	]	X
ecletica-510	216	4	de	de	PROPN
ecletica-510	216	5	azevedo	azevedo	PROPN
ecletica-510	216	6	,	,	PUNCT
ecletica-510	216	7	w.	w.	PROPN
ecletica-510	216	8	f.	f.	PROPN
ecletica-510	216	9	jr	jr	PROPN
ecletica-510	216	10	.	.	PROPN
ecletica-510	216	11	;	;	PUNCT
ecletica-510	216	12	canduri	canduri	PROPN
ecletica-510	216	13	,	,	PUNCT
ecletica-510	216	14	f.	f.	PROPN
ecletica-510	216	15	;	;	PUNCT
ecletica-510	216	16	fadel	fadel	PROPN
ecletica-510	216	17	,	,	PUNCT
ecletica-510	216	18	v.	v.	PROPN
ecletica-510	216	19	;	;	PUNCT
ecletica-510	216	20	teodoro	teodoro	PROPN
ecletica-510	216	21	,	,	PUNCT
ecletica-510	216	22	l.	l.	PROPN
ecletica-510	216	23	g.	g.	PROPN
ecletica-510	216	24	v.	v.	PROPN
ecletica-510	216	25	l.	l.	PROPN
ecletica-510	216	26	;	;	PUNCT
ecletica-510	216	27	hial	hial	NOUN
ecletica-510	216	28	,	,	PUNCT
ecletica-510	216	29	v.	v.	PROPN
ecletica-510	216	30	;	;	PUNCT
ecletica-510	216	31	gomes	gome	NOUN
ecletica-510	216	32	,	,	PUNCT
ecletica-510	216	33	r.	r.	PROPN
ecletica-510	216	34	a.	a.	PROPN
ecletica-510	216	35	s.	s.	PROPN
ecletica-510	216	36	molecular	molecular	ADJ
ecletica-510	216	37	model	model	NOUN
ecletica-510	216	38	for	for	ADP
ecletica-510	216	39	the	the	DET
ecletica-510	216	40	binary	binary	ADJ
ecletica-510	216	41	complex	complex	NOUN
ecletica-510	216	42	of	of	ADP
ecletica-510	216	43	uropepsin	uropepsin	NOUN
ecletica-510	216	44	and	and	CCONJ
ecletica-510	216	45	pepstatin	pepstatin	NOUN
ecletica-510	216	46	.	.	PUNCT
ecletica-510	217	1	biochem	biochem	PROPN
ecletica-510	217	2	.	.	PUNCT
ecletica-510	218	1	biophys	biophy	NOUN
ecletica-510	218	2	.	.	PUNCT
ecletica-510	219	1	res	re	NOUN
ecletica-510	219	2	.	.	PUNCT
ecletica-510	220	1	commun	commun	PROPN
ecletica-510	220	2	.	.	PROPN
ecletica-510	220	3	,	,	PUNCT
ecletica-510	220	4	v.	v.	ADP
ecletica-510	220	5	287	287	NUM
ecletica-510	220	6	,	,	PUNCT
ecletica-510	220	7	n.	n.	NOUN
ecletica-510	220	8	1	1	NUM
ecletica-510	220	9	,	,	PUNCT
ecletica-510	220	10	p.	p.	NOUN
ecletica-510	220	11	277	277	NUM
ecletica-510	220	12	-	-	SYM
ecletica-510	220	13	281	281	NUM
ecletica-510	220	14	,	,	PUNCT
ecletica-510	220	15	2001	2001	NUM
ecletica-510	220	16	.	.	PUNCT
ecletica-510	221	1	[	[	X
ecletica-510	221	2	14	14	NUM
ecletica-510	221	3	]	]	X
ecletica-510	221	4	de	de	PROPN
ecletica-510	221	5	azevedo	azevedo	PROPN
ecletica-510	221	6	,	,	PUNCT
ecletica-510	221	7	w.	w.	PROPN
ecletica-510	221	8	f.	f.	PROPN
ecletica-510	221	9	jr	jr	PROPN
ecletica-510	221	10	.	.	PROPN
ecletica-510	221	11	;	;	PUNCT
ecletica-510	221	12	canduri	canduri	PROPN
ecletica-510	221	13	,	,	PUNCT
ecletica-510	221	14	f.	f.	PROPN
ecletica-510	221	15	;	;	PUNCT
ecletica-510	221	16	silveira	silveira	PROPN
ecletica-510	221	17	,	,	PUNCT
ecletica-510	221	18	n.	n.	PROPN
ecletica-510	221	19	j.	j.	PROPN
ecletica-510	221	20	f.	f.	PROPN
ecletica-510	221	21	structural	structural	ADJ
ecletica-510	221	22	basis	basis	NOUN
ecletica-510	221	23	for	for	ADP
ecletica-510	221	24	inhibition	inhibition	NOUN
ecletica-510	221	25	of	of	ADP
ecletica-510	221	26	cyclin	cyclin	NOUN
ecletica-510	221	27	-	-	PUNCT
ecletica-510	221	28	dependent	dependent	ADJ
ecletica-510	221	29	kinase	kinase	NOUN
ecletica-510	221	30	9	9	NUM
ecletica-510	221	31	by	by	ADP
ecletica-510	221	32	flavopiridol	flavopiridol	PROPN
ecletica-510	221	33	.	.	PUNCT
ecletica-510	222	1	biochem	biochem	PROPN
ecletica-510	222	2	biophys	biophy	NOUN
ecletica-510	222	3	.	.	PUNCT
ecletica-510	223	1	res	re	NOUN
ecletica-510	223	2	.	.	PUNCT
ecletica-510	224	1	commun	commun	PROPN
ecletica-510	224	2	.	.	PROPN
ecletica-510	224	3	,	,	PUNCT
ecletica-510	224	4	v.	v.	ADP
ecletica-510	224	5	293	293	NUM
ecletica-510	224	6	,	,	PUNCT
ecletica-510	224	7	p.	p.	NOUN
ecletica-510	224	8	566	566	NUM
ecletica-510	224	9	-	-	SYM
ecletica-510	224	10	571	571	NUM
ecletica-510	224	11	,	,	PUNCT
ecletica-510	224	12	2002	2002	NUM
ecletica-510	224	13	.	.	PUNCT
ecletica-510	225	1	[	[	X
ecletica-510	225	2	15	15	NUM
ecletica-510	225	3	]	]	X
ecletica-510	225	4	de	de	PROPN
ecletica-510	225	5	azevedo	azevedo	PROPN
ecletica-510	225	6	,	,	PUNCT
ecletica-510	225	7	w.	w.	PROPN
ecletica-510	225	8	f.	f.	PROPN
ecletica-510	225	9	jr	jr	PROPN
ecletica-510	225	10	.	.	PROPN
ecletica-510	225	11	;	;	PUNCT
ecletica-510	225	12	gaspar	gaspar	PROPN
ecletica-510	225	13	,	,	PUNCT
ecletica-510	225	14	r.	r.	PROPN
ecletica-510	225	15	t.	t.	PROPN
ecletica-510	225	16	;	;	PUNCT
ecletica-510	225	17	canduri	canduri	PROPN
ecletica-510	225	18	,	,	PUNCT
ecletica-510	225	19	f.	f.	PROPN
ecletica-510	225	20	;	;	PUNCT
ecletica-510	225	21	camera	camera	NOUN
ecletica-510	225	22	,	,	PUNCT
ecletica-510	225	23	j.	j.	PROPN
ecletica-510	225	24	c.	c.	PROPN
ecletica-510	225	25	jr	jr	PROPN
ecletica-510	225	26	.	.	PROPN
ecletica-510	225	27	;	;	PUNCT
ecletica-510	225	28	silveira	silveira	PROPN
ecletica-510	225	29	,	,	PUNCT
ecletica-510	225	30	n.	n.	PROPN
ecletica-510	225	31	j.	j.	PROPN
ecletica-510	225	32	f.	f.	PROPN
ecletica-510	225	33	molecular	molecular	PROPN
ecletica-510	225	34	model	model	NOUN
ecletica-510	225	35	of	of	ADP
ecletica-510	225	36	cyclin	cyclin	NOUN
ecletica-510	225	37	-	-	PUNCT
ecletica-510	225	38	dependent	dependent	ADJ
ecletica-510	225	39	kinase	kinase	NOUN
ecletica-510	225	40	5	5	NUM
ecletica-510	225	41	complexed	complexe	VERB
ecletica-510	225	42	with	with	ADP
ecletica-510	225	43	roscovitine	roscovitine	NOUN
ecletica-510	225	44	.	.	PUNCT
ecletica-510	226	1	biochem	biochem	PROPN
ecletica-510	226	2	.	.	PUNCT
ecletica-510	227	1	biophys	biophy	NOUN
ecletica-510	227	2	.	.	PUNCT
ecletica-510	228	1	res	re	NOUN
ecletica-510	228	2	.	.	PUNCT
ecletica-510	229	1	commun	commun	PROPN
ecletica-510	229	2	.	.	PROPN
ecletica-510	229	3	,	,	PUNCT
ecletica-510	229	4	v.	v.	ADP
ecletica-510	229	5	297	297	NUM
ecletica-510	229	6	,	,	PUNCT
ecletica-510	229	7	p.	p.	NOUN
ecletica-510	229	8	1154	1154	NUM
ecletica-510	229	9	-	-	SYM
ecletica-510	229	10	1158	1158	NUM
ecletica-510	229	11	,	,	PUNCT
ecletica-510	229	12	2002	2002	NUM
ecletica-510	229	13	.	.	PUNCT
ecletica-510	230	1	[	[	X
ecletica-510	230	2	16	16	NUM
ecletica-510	230	3	]	]	X
ecletica-510	230	4	de	de	PROPN
ecletica-510	230	5	azevedo	azevedo	PROPN
ecletica-510	230	6	,	,	PUNCT
ecletica-510	230	7	w.	w.	PROPN
ecletica-510	230	8	f.	f.	PROPN
ecletica-510	230	9	jr	jr	PROPN
ecletica-510	230	10	.	.	PROPN
ecletica-510	230	11	;	;	PUNCT
ecletica-510	230	12	leclerc	leclerc	PROPN
ecletica-510	230	13	,	,	PUNCT
ecletica-510	230	14	s.	s.	PROPN
ecletica-510	230	15	;	;	PUNCT
ecletica-510	230	16	meijer	meijer	PROPN
ecletica-510	230	17	,	,	PUNCT
ecletica-510	230	18	l.	l.	PROPN
ecletica-510	230	19	;	;	PUNCT
ecletica-510	230	20	havlicek	havlicek	PROPN
ecletica-510	230	21	,	,	PUNCT
ecletica-510	230	22	l.	l.	PROPN
ecletica-510	230	23	;	;	PUNCT
ecletica-510	230	24	strnad	strnad	PROPN
ecletica-510	230	25	,	,	PUNCT
ecletica-510	230	26	m.	m.	NOUN
ecletica-510	230	27	;	;	PUNCT
ecletica-510	230	28	kim	kim	PROPN
ecletica-510	230	29	,	,	PUNCT
ecletica-510	230	30	s.-h	s.-h	NOUN
ecletica-510	230	31	.	.	PUNCT
ecletica-510	231	1	inhibition	inhibition	NOUN
ecletica-510	231	2	of	of	ADP
ecletica-510	231	3	cyclin	cyclin	NOUN
ecletica-510	231	4	-	-	PUNCT
ecletica-510	231	5	dependent	dependent	ADJ
ecletica-510	231	6	kinases	kinase	NOUN
ecletica-510	231	7	by	by	ADP
ecletica-510	231	8	purine	purine	NOUN
ecletica-510	231	9	analogues	analogue	NOUN
ecletica-510	231	10	:	:	PUNCT
ecletica-510	231	11	crystal	crystal	NOUN
ecletica-510	231	12	structure	structure	NOUN
ecletica-510	231	13	of	of	ADP
ecletica-510	231	14	human	human	ADJ
ecletica-510	231	15	cdk2	cdk2	PROPN
ecletica-510	231	16	complexed	complexe	VERB
ecletica-510	231	17	with	with	ADP
ecletica-510	231	18	roscovitine	roscovitine	NOUN
ecletica-510	231	19	.	.	PUNCT
ecletica-510	232	1	eur	eur	PROPN
ecletica-510	232	2	.	.	PUNCT
ecletica-510	233	1	j.	j.	PROPN
ecletica-510	233	2	biochem	biochem	PROPN
ecletica-510	233	3	.	.	PUNCT
ecletica-510	233	4	,	,	PUNCT
ecletica-510	234	1	v.	v.	ADP
ecletica-510	234	2	243	243	NUM
ecletica-510	234	3	,	,	PUNCT
ecletica-510	234	4	p.	p.	NOUN
ecletica-510	234	5	518	518	NUM
ecletica-510	234	6	-	-	SYM
ecletica-510	234	7	526	526	NUM
ecletica-510	234	8	,	,	PUNCT
ecletica-510	234	9	1997	1997	NUM
ecletica-510	234	10	.	.	PUNCT
ecletica-510	235	1	[	[	X
ecletica-510	235	2	17	17	NUM
ecletica-510	235	3	]	]	X
ecletica-510	235	4	de	de	PROPN
ecletica-510	235	5	azevedo	azevedo	PROPN
ecletica-510	235	6	,	,	PUNCT
ecletica-510	235	7	w.	w.	PROPN
ecletica-510	235	8	f.	f.	PROPN
ecletica-510	235	9	jr	jr	PROPN
ecletica-510	235	10	.	.	PROPN
ecletica-510	235	11	;	;	PUNCT
ecletica-510	235	12	mueller	mueller	NOUN
ecletica-510	235	13	-	-	PUNCT
ecletica-510	235	14	dieckmann	dieckmann	PROPN
ecletica-510	235	15	,	,	PUNCT
ecletica-510	235	16	h.;j	h.;j	PROPN
ecletica-510	235	17	.	.	PUNCT
ecletica-510	235	18	;	;	PUNCT
ecletica-510	235	19	schulze	schulze	NOUN
ecletica-510	235	20	-	-	PUNCT
ecletica-510	235	21	gahmen	gahmen	PROPN
ecletica-510	235	22	,	,	PUNCT
ecletica-510	235	23	u.	u.	PROPN
ecletica-510	235	24	;	;	PUNCT
ecletica-510	235	25	worland	worland	PROPN
ecletica-510	235	26	,	,	PUNCT
ecletica-510	235	27	p.	p.	PROPN
ecletica-510	235	28	j.	j.	PROPN
ecletica-510	235	29	;	;	PUNCT
ecletica-510	235	30	sausville	sausville	PROPN
ecletica-510	235	31	,	,	PUNCT
ecletica-510	235	32	e.	e.	PROPN
ecletica-510	235	33	;	;	PUNCT
ecletica-510	235	34	kim	kim	PROPN
ecletica-510	235	35	s.-h	s.-h	PROPN
ecletica-510	235	36	.	.	PUNCT
ecletica-510	236	1	structural	structural	ADJ
ecletica-510	236	2	basis	basis	NOUN
ecletica-510	236	3	for	for	ADP
ecletica-510	236	4	specificity	specificity	NOUN
ecletica-510	236	5	and	and	CCONJ
ecletica-510	236	6	potency	potency	NOUN
ecletica-510	236	7	of	of	ADP
ecletica-510	236	8	a	a	DET
ecletica-510	236	9	flavonoid	flavonoid	NOUN
ecletica-510	236	10	inhibitor	inhibitor	NOUN
ecletica-510	236	11	of	of	ADP
ecletica-510	236	12	human	human	ADJ
ecletica-510	236	13	cdk2	cdk2	PROPN
ecletica-510	236	14	,	,	PUNCT
ecletica-510	236	15	a	a	DET
ecletica-510	236	16	cell	cell	NOUN
ecletica-510	236	17	cycle	cycle	NOUN
ecletica-510	236	18	kinase	kinase	PROPN
ecletica-510	236	19	.	.	PUNCT
ecletica-510	237	1	proc	proc	PROPN
ecletica-510	237	2	.	.	PUNCT
ecletica-510	238	1	natl	natl	PROPN
ecletica-510	238	2	.	.	PUNCT
ecletica-510	239	1	acad	acad	PROPN
ecletica-510	239	2	.	.	PUNCT
ecletica-510	240	1	sci	sci	PROPN
ecletica-510	240	2	.	.	PROPN
ecletica-510	240	3	usa	usa	PROPN
ecletica-510	240	4	.	.	PROPN
ecletica-510	240	5	,	,	PUNCT
ecletica-510	240	6	v.	v.	ADP
ecletica-510	240	7	93	93	NUM
ecletica-510	240	8	,	,	PUNCT
ecletica-510	240	9	n.	n.	NOUN
ecletica-510	240	10	7	7	NUM
ecletica-510	240	11	,	,	PUNCT
ecletica-510	240	12	p.	p.	NOUN
ecletica-510	240	13	2735	2735	NUM
ecletica-510	240	14	-	-	SYM
ecletica-510	240	15	2740	2740	NUM
ecletica-510	240	16	,	,	PUNCT
ecletica-510	240	17	1996	1996	NUM
ecletica-510	240	18	.	.	PUNCT
ecletica-510	241	1	[	[	X
ecletica-510	241	2	18	18	NUM
ecletica-510	241	3	]	]	X
ecletica-510	241	4	debondt	debondt	NOUN
ecletica-510	241	5	,	,	PUNCT
ecletica-510	241	6	h.	h.	PROPN
ecletica-510	241	7	l.	l.	PROPN
ecletica-510	241	8	;	;	PUNCT
ecletica-510	241	9	rosenblatt	rosenblatt	PROPN
ecletica-510	241	10	,	,	PUNCT
ecletica-510	241	11	j.	j.	PROPN
ecletica-510	241	12	;	;	PUNCT
ecletica-510	241	13	jancarik	jancarik	PROPN
ecletica-510	241	14	,	,	PUNCT
ecletica-510	241	15	j.	j.	PROPN
ecletica-510	241	16	;	;	PUNCT
ecletica-510	241	17	jones	jones	PROPN
ecletica-510	241	18	,	,	PUNCT
ecletica-510	241	19	h.	h.	PROPN
ecletica-510	241	20	d.	d.	PROPN
ecletica-510	241	21	;	;	PUNCT
ecletica-510	241	22	morgan	morgan	PROPN
ecletica-510	241	23	,	,	PUNCT
ecletica-510	241	24	d.	d.	PROPN
ecletica-510	241	25	o.	o.	PROPN
ecletica-510	241	26	;	;	PUNCT
ecletica-510	241	27	kim	kim	PROPN
ecletica-510	241	28	,	,	PUNCT
ecletica-510	241	29	s.-h	s.-h	NOUN
ecletica-510	241	30	.	.	PUNCT
ecletica-510	242	1	crystal	crystal	NOUN
ecletica-510	242	2	structural	structural	NOUN
ecletica-510	242	3	of	of	ADP
ecletica-510	242	4	cyclin	cyclin	NOUN
ecletica-510	242	5	-	-	PUNCT
ecletica-510	242	6	dependent	dependent	ADJ
ecletica-510	242	7	kinase	kinase	NOUN
ecletica-510	242	8	2	2	X
ecletica-510	242	9	.	.	PUNCT
ecletica-510	243	1	nature	nature	NOUN
ecletica-510	243	2	,	,	PUNCT
ecletica-510	243	3	v.	v.	ADP
ecletica-510	243	4	363	363	NUM
ecletica-510	243	5	,	,	PUNCT
ecletica-510	243	6	p.	p.	NOUN
ecletica-510	243	7	595	595	NUM
ecletica-510	243	8	-	-	SYM
ecletica-510	243	9	602	602	NUM
ecletica-510	243	10	,	,	PUNCT
ecletica-510	243	11	1993	1993	NUM
ecletica-510	243	12	.	.	PUNCT
ecletica-510	244	1	[	[	X
ecletica-510	244	2	19	19	NUM
ecletica-510	244	3	]	]	X
ecletica-510	244	4	desai	desai	PROPN
ecletica-510	244	5	,	,	PUNCT
ecletica-510	244	6	d.	d.	PROPN
ecletica-510	244	7	;	;	PUNCT
ecletica-510	244	8	gu	gu	PROPN
ecletica-510	244	9	,	,	PUNCT
ecletica-510	244	10	y.	y.	PROPN
ecletica-510	244	11	;	;	PUNCT
ecletica-510	244	12	morgan	morgan	PROPN
ecletica-510	244	13	,	,	PUNCT
ecletica-510	244	14	d.	d.	PROPN
ecletica-510	244	15	o.	o.	PROPN
ecletica-510	244	16	activation	activation	NOUN
ecletica-510	244	17	of	of	ADP
ecletica-510	244	18	human	human	ADJ
ecletica-510	244	19	cyclin	cyclin	NOUN
ecletica-510	244	20	-	-	PUNCT
ecletica-510	244	21	dependent	dependent	ADJ
ecletica-510	244	22	kinases	kinase	NOUN
ecletica-510	244	23	in	in	ADP
ecletica-510	244	24	vitro	vitro	X
ecletica-510	244	25	.	.	PUNCT
ecletica-510	245	1	mol	mol	X
ecletica-510	245	2	.	.	PUNCT
ecletica-510	246	1	biol	biol	PROPN
ecletica-510	246	2	.	.	PUNCT
ecletica-510	247	1	cell	cell	NOUN
ecletica-510	247	2	,	,	PUNCT
ecletica-510	247	3	v.	v.	ADP
ecletica-510	247	4	3	3	NUM
ecletica-510	247	5	,	,	PUNCT
ecletica-510	247	6	p.	p.	NOUN
ecletica-510	247	7	571	571	NUM
ecletica-510	247	8	-	-	SYM
ecletica-510	247	9	582	582	NUM
ecletica-510	247	10	,	,	PUNCT
ecletica-510	247	11	1992	1992	NUM
ecletica-510	247	12	.	.	PUNCT
ecletica-510	248	1	[	[	X
ecletica-510	248	2	20	20	NUM
ecletica-510	248	3	]	]	X
ecletica-510	248	4	gray	gray	ADJ
ecletica-510	248	5	,	,	PUNCT
ecletica-510	248	6	n.	n.	NOUN
ecletica-510	248	7	;	;	PUNCT
ecletica-510	248	8	detivaud	detivaud	PROPN
ecletica-510	248	9	,	,	PUNCT
ecletica-510	248	10	l.	l.	PROPN
ecletica-510	248	11	;	;	PUNCT
ecletica-510	248	12	doerig	doerig	PROPN
ecletica-510	248	13	,	,	PUNCT
ecletica-510	248	14	c.	c.	NOUN
ecletica-510	248	15	;	;	PUNCT
ecletica-510	248	16	meijer	meijer	PROPN
ecletica-510	248	17	,	,	PUNCT
ecletica-510	248	18	l.	l.	PROPN
ecletica-510	248	19	atp	atp	PROPN
ecletica-510	248	20	-	-	PUNCT
ecletica-510	248	21	site	site	NOUN
ecletica-510	248	22	directed	direct	VERB
ecletica-510	248	23	inhibitors	inhibitor	NOUN
ecletica-510	248	24	of	of	ADP
ecletica-510	248	25	cyclin	cyclin	NOUN
ecletica-510	248	26	-	-	PUNCT
ecletica-510	248	27	dependent	dependent	ADJ
ecletica-510	248	28	kinases	kinase	NOUN
ecletica-510	248	29	.	.	PUNCT
ecletica-510	249	1	ecl	ecl	PROPN
ecletica-510	249	2	.	.	PROPN
ecletica-510	249	3	quím	quím	PROPN
ecletica-510	249	4	.	.	PUNCT
ecletica-510	250	1	,	,	PUNCT
ecletica-510	250	2	são	são	PROPN
ecletica-510	250	3	paulo	paulo	PROPN
ecletica-510	250	4	,	,	PUNCT
ecletica-510	250	5	28(1	28(1	NOUN
ecletica-510	250	6	):	):	PUNCT
ecletica-510	250	7	45	45	NUM
ecletica-510	250	8	-	-	SYM
ecletica-510	250	9	53	53	NUM
ecletica-510	250	10	,	,	PUNCT
ecletica-510	250	11	2003	2003	NUM
ecletica-510	250	12	53	53	NUM
ecletica-510	250	13	curr	curr	X
ecletica-510	250	14	.	.	PUNCT
ecletica-510	250	15	med	med	PROPN
ecletica-510	250	16	.	.	PROPN
ecletica-510	250	17	chem	chem	PROPN
ecletica-510	250	18	.	.	PUNCT
ecletica-510	251	1	v.	v.	ADP
ecletica-510	251	2	6	6	NUM
ecletica-510	251	3	,	,	PUNCT
ecletica-510	251	4	n.	n.	NOUN
ecletica-510	251	5	9	9	NUM
ecletica-510	251	6	,	,	PUNCT
ecletica-510	251	7	p.	p.	NOUN
ecletica-510	251	8	859	859	NUM
ecletica-510	251	9	-	-	SYM
ecletica-510	251	10	875	875	NUM
ecletica-510	251	11	,	,	PUNCT
ecletica-510	251	12	1999	1999	NUM
ecletica-510	251	13	.	.	PUNCT
ecletica-510	252	1	[	[	X
ecletica-510	252	2	21	21	NUM
ecletica-510	252	3	]	]	X
ecletica-510	252	4	gray	gray	ADJ
ecletica-510	252	5	,	,	PUNCT
ecletica-510	252	6	n.	n.	PROPN
ecletica-510	252	7	s.	s.	PROPN
ecletica-510	252	8	;	;	PUNCT
ecletica-510	252	9	wodicka	wodicka	PROPN
ecletica-510	252	10	,	,	PUNCT
ecletica-510	252	11	l.	l.	PROPN
ecletica-510	252	12	;	;	PUNCT
ecletica-510	252	13	thunniessen	thunniessen	PROPN
ecletica-510	252	14	,	,	PUNCT
ecletica-510	252	15	a.	a.	NOUN
ecletica-510	252	16	m.	m.	NOUN
ecletica-510	252	17	;	;	PUNCT
ecletica-510	252	18	norman	norman	PROPN
ecletica-510	252	19	,	,	PUNCT
ecletica-510	252	20	t.	t.	PROPN
ecletica-510	252	21	c.	c.	PROPN
ecletica-510	252	22	;	;	PUNCT
ecletica-510	252	23	kwon	kwon	PROPN
ecletica-510	252	24	,	,	PUNCT
ecletica-510	252	25	s.	s.	PROPN
ecletica-510	252	26	;	;	PUNCT
ecletica-510	252	27	espinoza	espinoza	PROPN
ecletica-510	252	28	,	,	PUNCT
ecletica-510	252	29	f.	f.	PROPN
ecletica-510	252	30	h.	h.	PROPN
ecletica-510	252	31	;	;	PUNCT
ecletica-510	252	32	morgan	morgan	PROPN
ecletica-510	252	33	,	,	PUNCT
ecletica-510	252	34	d.	d.	PROPN
ecletica-510	252	35	o.	o.	PROPN
ecletica-510	252	36	;	;	PUNCT
ecletica-510	252	37	barnes	barnes	PROPN
ecletica-510	252	38	,	,	PUNCT
ecletica-510	252	39	g.	g.	PROPN
ecletica-510	252	40	;	;	PUNCT
ecletica-510	252	41	leclerc	leclerc	PROPN
ecletica-510	252	42	,	,	PUNCT
ecletica-510	252	43	s.	s.	PROPN
ecletica-510	252	44	;	;	PUNCT
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ecletica-510	252	46	,	,	PUNCT
ecletica-510	252	47	l.	l.	PROPN
ecletica-510	252	48	;	;	PUNCT
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ecletica-510	252	50	,	,	PUNCT
ecletica-510	252	51	s.	s.	PROPN
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ecletica-510	252	53	;	;	PUNCT
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ecletica-510	252	58	;	;	PUNCT
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ecletica-510	252	61	p.	p.	NOUN
ecletica-510	252	62	g.	g.	NOUN
ecletica-510	252	63	exploiting	exploit	VERB
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ecletica-510	252	65	libraries	library	NOUN
ecletica-510	252	66	,	,	PUNCT
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ecletica-510	252	68	,	,	PUNCT
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ecletica-510	252	71	in	in	ADP
ecletica-510	252	72	the	the	DET
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ecletica-510	252	74	for	for	ADP
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ecletica-510	252	77	.	.	PUNCT
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ecletica-510	253	2	,	,	PUNCT
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ecletica-510	253	5	,	,	PUNCT
ecletica-510	253	6	p.	p.	NOUN
ecletica-510	253	7	533	533	NUM
ecletica-510	253	8	-	-	SYM
ecletica-510	253	9	538	538	NUM
ecletica-510	253	10	,	,	PUNCT
ecletica-510	253	11	1998	1998	NUM
ecletica-510	253	12	.	.	PUNCT
ecletica-510	254	1	[	[	X
ecletica-510	254	2	22	22	NUM
ecletica-510	254	3	]	]	SYM
ecletica-510	254	4	hoessel	hoessel	PROPN
ecletica-510	254	5	,	,	PUNCT
ecletica-510	254	6	r.	r.	PROPN
ecletica-510	254	7	;	;	PUNCT
ecletica-510	254	8	leclerc	leclerc	PROPN
ecletica-510	254	9	,	,	PUNCT
ecletica-510	254	10	s.	s.	PROPN
ecletica-510	254	11	;	;	PUNCT
ecletica-510	254	12	endicott	endicott	PROPN
ecletica-510	254	13	,	,	PUNCT
ecletica-510	254	14	j.	j.	PROPN
ecletica-510	254	15	a.	a.	PROPN
ecletica-510	254	16	;	;	PUNCT
ecletica-510	254	17	nobel	nobel	PROPN
ecletica-510	254	18	,	,	PUNCT
ecletica-510	254	19	m.	m.	PROPN
ecletica-510	254	20	e.	e.	PROPN
ecletica-510	254	21	;	;	PUNCT
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ecletica-510	254	23	,	,	PUNCT
ecletica-510	254	24	a.	a.	NOUN
ecletica-510	254	25	;	;	PUNCT
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ecletica-510	254	28	p.	p.	PROPN
ecletica-510	254	29	;	;	PUNCT
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ecletica-510	254	31	,	,	PUNCT
ecletica-510	254	32	m.	m.	NOUN
ecletica-510	254	33	;	;	PUNCT
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ecletica-510	254	35	,	,	PUNCT
ecletica-510	254	36	e.	e.	PROPN
ecletica-510	254	37	;	;	PUNCT
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ecletica-510	254	39	,	,	PUNCT
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ecletica-510	254	41	;	;	PUNCT
ecletica-510	254	42	marko	marko	PROPN
ecletica-510	254	43	,	,	PUNCT
ecletica-510	254	44	d.	d.	PROPN
ecletica-510	254	45	;	;	PUNCT
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ecletica-510	254	47	,	,	PUNCT
ecletica-510	254	48	e.	e.	PROPN
ecletica-510	254	49	;	;	PUNCT
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ecletica-510	254	52	w.	w.	PROPN
ecletica-510	254	53	;	;	PUNCT
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ecletica-510	254	55	,	,	PUNCT
ecletica-510	254	56	g.	g.	PROPN
ecletica-510	254	57	;	;	PUNCT
ecletica-510	254	58	meijer	meijer	PROPN
ecletica-510	254	59	,	,	PUNCT
ecletica-510	254	60	l.	l.	PROPN
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ecletica-510	254	62	,	,	PUNCT
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ecletica-510	254	77	.	.	PUNCT
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ecletica-510	255	2	.	.	PUNCT
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ecletica-510	256	9	1	1	NUM
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ecletica-510	256	13	-	-	SYM
ecletica-510	256	14	67	67	NUM
ecletica-510	256	15	,	,	PUNCT
ecletica-510	256	16	1999	1999	NUM
ecletica-510	256	17	.	.	PUNCT
ecletica-510	257	1	[	[	X
ecletica-510	257	2	23	23	NUM
ecletica-510	257	3	]	]	X
ecletica-510	257	4	kim	kim	PROPN
ecletica-510	257	5	,	,	PUNCT
ecletica-510	257	6	s.-h	s.-h	NOUN
ecletica-510	257	7	.	.	PUNCT
ecletica-510	257	8	;	;	PUNCT
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ecletica-510	257	10	-	-	PUNCT
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ecletica-510	257	12	,	,	PUNCT
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ecletica-510	257	14	;	;	PUNCT
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ecletica-510	257	16	,	,	PUNCT
ecletica-510	257	17	j.	j.	PROPN
ecletica-510	257	18	;	;	PUNCT
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ecletica-510	257	21	,	,	PUNCT
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ecletica-510	257	23	f.	f.	PROPN
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ecletica-510	257	25	.	.	PROPN
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ecletica-510	257	32	cdk2	cdk2	PROPN
ecletica-510	257	33	.	.	PUNCT
ecletica-510	258	1	prog	prog	PROPN
ecletica-510	258	2	.	.	PUNCT
ecletica-510	259	1	cell	cell	NOUN
ecletica-510	259	2	cycle	cycle	NOUN
ecletica-510	259	3	res	re	NOUN
ecletica-510	259	4	.	.	PUNCT
ecletica-510	259	5	,	,	PUNCT
ecletica-510	260	1	v.	v.	ADP
ecletica-510	260	2	2	2	NUM
ecletica-510	260	3	,	,	PUNCT
ecletica-510	260	4	p.	p.	NOUN
ecletica-510	260	5	137	137	NUM
ecletica-510	260	6	-	-	SYM
ecletica-510	260	7	145	145	NUM
ecletica-510	260	8	,	,	PUNCT
ecletica-510	260	9	1996	1996	NUM
ecletica-510	260	10	.	.	PUNCT
ecletica-510	261	1	[	[	X
ecletica-510	261	2	24	24	NUM
ecletica-510	261	3	]	]	X
ecletica-510	261	4	kraulis	kraulis	PROPN
ecletica-510	261	5	,	,	PUNCT
ecletica-510	261	6	p.	p.	NOUN
ecletica-510	261	7	molscript	molscript	PROPN
ecletica-510	261	8	:	:	PUNCT
ecletica-510	261	9	a	a	DET
ecletica-510	261	10	program	program	NOUN
ecletica-510	261	11	to	to	PART
ecletica-510	261	12	produce	produce	VERB
ecletica-510	261	13	both	both	CCONJ
ecletica-510	261	14	detailed	detailed	ADJ
ecletica-510	261	15	and	and	CCONJ
ecletica-510	261	16	schematic	schematic	ADJ
ecletica-510	261	17	plots	plot	NOUN
ecletica-510	261	18	of	of	ADP
ecletica-510	261	19	proteins	protein	NOUN
ecletica-510	261	20	.	.	PUNCT
ecletica-510	262	1	j.	j.	PROPN
ecletica-510	262	2	app	app	PROPN
ecletica-510	262	3	.	.	PUNCT
ecletica-510	263	1	cryst	cryst	PROPN
ecletica-510	263	2	.	.	PUNCT
ecletica-510	264	1	,	,	PUNCT
ecletica-510	264	2	v.	v.	ADP
ecletica-510	264	3	24	24	NUM
ecletica-510	264	4	,	,	PUNCT
ecletica-510	264	5	p.	p.	NOUN
ecletica-510	264	6	946	946	NUM
ecletica-510	264	7	-	-	SYM
ecletica-510	264	8	950	950	NUM
ecletica-510	264	9	,	,	PUNCT
ecletica-510	264	10	1991	1991	NUM
ecletica-510	264	11	.	.	PUNCT
ecletica-510	265	1	[	[	X
ecletica-510	265	2	25	25	NUM
ecletica-510	265	3	]	]	X
ecletica-510	265	4	kroemer	kroemer	PROPN
ecletica-510	265	5	,	,	PUNCT
ecletica-510	265	6	r.	r.	PROPN
ecletica-510	265	7	t.	t.	PROPN
ecletica-510	265	8	;	;	PUNCT
ecletica-510	265	9	doughty	doughty	VERB
ecletica-510	265	10	,	,	PUNCT
ecletica-510	265	11	s.	s.	PROPN
ecletica-510	265	12	w.	w.	PROPN
ecletica-510	265	13	;	;	PUNCT
ecletica-510	265	14	robinson	robinson	PROPN
ecletica-510	265	15	,	,	PUNCT
ecletica-510	265	16	a.	a.	PROPN
ecletica-510	265	17	j.	j.	PROPN
ecletica-510	265	18	;	;	PUNCT
ecletica-510	265	19	richards	richards	PROPN
ecletica-510	265	20	,	,	PUNCT
ecletica-510	265	21	w.	w.	PROPN
ecletica-510	265	22	g.	g.	PROPN
ecletica-510	265	23	prediction	prediction	NOUN
ecletica-510	265	24	of	of	ADP
ecletica-510	265	25	the	the	DET
ecletica-510	265	26	three	three	NUM
ecletica-510	265	27	-	-	PUNCT
ecletica-510	265	28	dimensional	dimensional	ADJ
ecletica-510	265	29	structure	structure	NOUN
ecletica-510	265	30	of	of	ADP
ecletica-510	265	31	human	human	ADJ
ecletica-510	265	32	interleukin-7	interleukin-7	PROPN
ecletica-510	265	33	by	by	ADP
ecletica-510	265	34	homology	homology	NOUN
ecletica-510	265	35	modeling	modeling	NOUN
ecletica-510	265	36	.	.	PUNCT
ecletica-510	266	1	protein	protein	NOUN
ecletica-510	266	2	eng	eng	PROPN
ecletica-510	266	3	.	.	PROPN
ecletica-510	266	4	,	,	PUNCT
ecletica-510	266	5	v.	v.	ADP
ecletica-510	266	6	9	9	NUM
ecletica-510	266	7	,	,	PUNCT
ecletica-510	266	8	n.	n.	NOUN
ecletica-510	266	9	6	6	NUM
ecletica-510	266	10	,	,	PUNCT
ecletica-510	266	11	p.	p.	NOUN
ecletica-510	266	12	493	493	NUM
ecletica-510	266	13	-	-	SYM
ecletica-510	266	14	498	498	NUM
ecletica-510	266	15	,	,	PUNCT
ecletica-510	266	16	1996	1996	NUM
ecletica-510	266	17	.	.	PUNCT
ecletica-510	267	1	[	[	X
ecletica-510	267	2	26	26	NUM
ecletica-510	267	3	]	]	X
ecletica-510	267	4	laskowski	laskowski	NOUN
ecletica-510	267	5	,	,	PUNCT
ecletica-510	267	6	r.	r.	PROPN
ecletica-510	267	7	a.	a.	PROPN
ecletica-510	267	8	;	;	PUNCT
ecletica-510	267	9	macarthur	macarthur	PROPN
ecletica-510	267	10	,	,	PUNCT
ecletica-510	267	11	m.	m.	PROPN
ecletica-510	267	12	w.	w.	PROPN
ecletica-510	267	13	;	;	PUNCT
ecletica-510	267	14	smith	smith	PROPN
ecletica-510	267	15	,	,	PUNCT
ecletica-510	267	16	d.	d.	PROPN
ecletica-510	267	17	k.	k.	PROPN
ecletica-510	267	18	;	;	PUNCT
ecletica-510	267	19	jones	jones	PROPN
ecletica-510	267	20	,	,	PUNCT
ecletica-510	267	21	d.	d.	PROPN
ecletica-510	267	22	t.	t.	PROPN
ecletica-510	267	23	;	;	PUNCT
ecletica-510	267	24	hutchinson	hutchinson	PROPN
ecletica-510	267	25	,	,	PUNCT
ecletica-510	267	26	e.	e.	PROPN
ecletica-510	267	27	g.	g.	PROPN
ecletica-510	267	28	;	;	PUNCT
ecletica-510	267	29	morris	morris	PROPN
ecletica-510	267	30	,	,	PUNCT
ecletica-510	267	31	a	a	PRON
ecletica-510	267	32	,	,	PUNCT
ecletica-510	267	33	l.	l.	PROPN
ecletica-510	267	34	;	;	PUNCT
ecletica-510	267	35	naylor	naylor	PROPN
ecletica-510	267	36	,	,	PUNCT
ecletica-510	267	37	d.	d.	PROPN
ecletica-510	267	38	;	;	PUNCT
ecletica-510	267	39	moss	moss	PROPN
ecletica-510	267	40	,	,	PUNCT
ecletica-510	267	41	d.	d.	PROPN
ecletica-510	267	42	s.	s.	PROPN
ecletica-510	267	43	;	;	PUNCT
ecletica-510	267	44	thorton	thorton	PROPN
ecletica-510	267	45	,	,	PUNCT
ecletica-510	267	46	j.	j.	PROPN
ecletica-510	267	47	m.	m.	PROPN
ecletica-510	267	48	procheck	procheck	PROPN
ecletica-510	267	49	v.3.0	v.3.0	NOUN
ecletica-510	267	50	:	:	PUNCT
ecletica-510	267	51	program	program	NOUN
ecletica-510	267	52	to	to	PART
ecletica-510	267	53	check	check	VERB
ecletica-510	267	54	the	the	DET
ecletica-510	267	55	stereochemistry	stereochemistry	NOUN
ecletica-510	267	56	quality	quality	NOUN
ecletica-510	267	57	of	of	ADP
ecletica-510	267	58	protein	protein	NOUN
ecletica-510	267	59	structures	structure	NOUN
ecletica-510	267	60	operating	operating	NOUN
ecletica-510	267	61	instructions	instruction	NOUN
ecletica-510	267	62	,	,	PUNCT
ecletica-510	267	63	[	[	X
ecletica-510	267	64	s.l.:s.n	s.l.:s.n	NOUN
ecletica-510	267	65	.	.	PUNCT
ecletica-510	267	66	]	]	X
ecletica-510	267	67	,	,	PUNCT
ecletica-510	267	68	1994	1994	NUM
ecletica-510	267	69	.	.	PUNCT
ecletica-510	268	1	[	[	X
ecletica-510	268	2	27	27	NUM
ecletica-510	268	3	]	]	X
ecletica-510	268	4	lawrie	lawrie	PROPN
ecletica-510	268	5	,	,	PUNCT
ecletica-510	268	6	a.	a.	NOUN
ecletica-510	268	7	m.	m.	NOUN
ecletica-510	268	8	;	;	PUNCT
ecletica-510	268	9	noble	noble	ADJ
ecletica-510	268	10	,	,	PUNCT
ecletica-510	268	11	m.	m.	NOUN
ecletica-510	268	12	e.	e.	PROPN
ecletica-510	268	13	;	;	PUNCT
ecletica-510	268	14	tunnah	tunnah	PROPN
ecletica-510	268	15	,	,	PUNCT
ecletica-510	268	16	p.	p.	PROPN
ecletica-510	268	17	;	;	PUNCT
ecletica-510	268	18	brown	brown	PROPN
ecletica-510	268	19	,	,	PUNCT
ecletica-510	268	20	n.	n.	PROPN
ecletica-510	268	21	r.	r.	PROPN
ecletica-510	268	22	;	;	PUNCT
ecletica-510	268	23	johnson	johnson	PROPN
ecletica-510	268	24	,	,	PUNCT
ecletica-510	268	25	l.	l.	PROPN
ecletica-510	268	26	n.	n.	PROPN
ecletica-510	268	27	;	;	PUNCT
ecletica-510	268	28	endicott	endicott	PROPN
ecletica-510	268	29	,	,	PUNCT
ecletica-510	268	30	j.	j.	PROPN
ecletica-510	268	31	a.	a.	PROPN
ecletica-510	268	32	protein	protein	PROPN
ecletica-510	268	33	kinase	kinase	PROPN
ecletica-510	268	34	inhibition	inhibition	NOUN
ecletica-510	268	35	by	by	ADP
ecletica-510	268	36	staurosporine	staurosporine	NOUN
ecletica-510	268	37	revealed	reveal	VERB
ecletica-510	268	38	in	in	ADP
ecletica-510	268	39	details	detail	NOUN
ecletica-510	268	40	of	of	ADP
ecletica-510	268	41	the	the	DET
ecletica-510	268	42	molecular	molecular	ADJ
ecletica-510	268	43	interaction	interaction	NOUN
ecletica-510	268	44	with	with	ADP
ecletica-510	268	45	cdk2	cdk2	PROPN
ecletica-510	268	46	.	.	PUNCT
ecletica-510	269	1	nat	nat	PROPN
ecletica-510	269	2	.	.	PUNCT
ecletica-510	269	3	struct	struct	NOUN
ecletica-510	269	4	.	.	PUNCT
ecletica-510	270	1	biol	biol	PROPN
ecletica-510	270	2	.	.	PUNCT
ecletica-510	270	3	,	,	PUNCT
ecletica-510	270	4	v.	v.	ADP
ecletica-510	270	5	4	4	NUM
ecletica-510	270	6	,	,	PUNCT
ecletica-510	270	7	p.	p.	NOUN
ecletica-510	270	8	796	796	NUM
ecletica-510	270	9	,	,	PUNCT
ecletica-510	270	10	1997	1997	NUM
ecletica-510	270	11	.	.	PUNCT
ecletica-510	271	1	[	[	X
ecletica-510	271	2	28	28	NUM
ecletica-510	271	3	]	]	X
ecletica-510	271	4	meijer	meijer	PROPN
ecletica-510	271	5	,	,	PUNCT
ecletica-510	271	6	l.	l.	PROPN
ecletica-510	271	7	;	;	PUNCT
ecletica-510	271	8	borgne	borgne	PROPN
ecletica-510	271	9	,	,	PUNCT
ecletica-510	271	10	a.	a.	NOUN
ecletica-510	271	11	;	;	PUNCT
ecletica-510	271	12	mulner	mulner	ADJ
ecletica-510	271	13	,	,	PUNCT
ecletica-510	271	14	o.	o.	PROPN
ecletica-510	271	15	;	;	PUNCT
ecletica-510	271	16	chong	chong	PROPN
ecletica-510	271	17	,	,	PUNCT
ecletica-510	271	18	j.	j.	PROPN
ecletica-510	271	19	p.	p.	PROPN
ecletica-510	271	20	;	;	PUNCT
ecletica-510	271	21	blow	blow	PROPN
ecletica-510	271	22	,	,	PUNCT
ecletica-510	271	23	j.	j.	PROPN
ecletica-510	271	24	j.	j.	PROPN
ecletica-510	271	25	;	;	PUNCT
ecletica-510	271	26	inagaki	inagaki	PROPN
ecletica-510	271	27	,	,	PUNCT
ecletica-510	271	28	n.	n.	ADJ
ecletica-510	271	29	biochemical	biochemical	ADJ
ecletica-510	271	30	and	and	CCONJ
ecletica-510	271	31	cellular	cellular	ADJ
ecletica-510	271	32	effects	effect	NOUN
ecletica-510	271	33	of	of	ADP
ecletica-510	271	34	roscovitine	roscovitine	NOUN
ecletica-510	271	35	,	,	PUNCT
ecletica-510	271	36	a	a	DET
ecletica-510	271	37	patent	patent	NOUN
ecletica-510	271	38	and	and	CCONJ
ecletica-510	271	39	selective	selective	ADJ
ecletica-510	271	40	inhibitor	inhibitor	NOUN
ecletica-510	271	41	of	of	ADP
ecletica-510	271	42	the	the	DET
ecletica-510	271	43	cyclin	cyclin	NOUN
ecletica-510	271	44	-	-	PUNCT
ecletica-510	271	45	dependent	dependent	ADJ
ecletica-510	271	46	kinases	kinase	NOUN
ecletica-510	271	47	cdk2	cdk2	PROPN
ecletica-510	271	48	and	and	CCONJ
ecletica-510	271	49	cdk5	cdk5	PROPN
ecletica-510	271	50	.	.	PUNCT
ecletica-510	272	1	eur	eur	PROPN
ecletica-510	272	2	.	.	PUNCT
ecletica-510	273	1	j.	j.	PROPN
ecletica-510	273	2	biochem	biochem	PROPN
ecletica-510	273	3	.	.	PUNCT
ecletica-510	273	4	,	,	PUNCT
ecletica-510	274	1	v.	v.	ADP
ecletica-510	274	2	243	243	NUM
ecletica-510	274	3	,	,	PUNCT
ecletica-510	274	4	p.	p.	NOUN
ecletica-510	274	5	527	527	NUM
ecletica-510	274	6	-	-	SYM
ecletica-510	274	7	536	536	NUM
ecletica-510	274	8	,	,	PUNCT
ecletica-510	274	9	1997	1997	NUM
ecletica-510	274	10	.	.	PUNCT
ecletica-510	275	1	[	[	X
ecletica-510	275	2	29	29	NUM
ecletica-510	275	3	]	]	X
ecletica-510	275	4	meijer	meijer	PROPN
ecletica-510	275	5	,	,	PUNCT
ecletica-510	275	6	l.	l.	PROPN
ecletica-510	275	7	;	;	PUNCT
ecletica-510	275	8	thunnissen	thunnissen	PROPN
ecletica-510	275	9	,	,	PUNCT
ecletica-510	275	10	a.	a.	NOUN
ecletica-510	275	11	m.	m.	NOUN
ecletica-510	275	12	;	;	PUNCT
ecletica-510	275	13	white	white	ADJ
ecletica-510	275	14	,	,	PUNCT
ecletica-510	275	15	a.	a.	PROPN
ecletica-510	275	16	w.	w.	PROPN
ecletica-510	275	17	;	;	PUNCT
ecletica-510	275	18	garnier	garnier	PROPN
ecletica-510	275	19	,	,	PUNCT
ecletica-510	275	20	m.	m.	NOUN
ecletica-510	275	21	;	;	PUNCT
ecletica-510	275	22	nikolic	nikolic	PROPN
ecletica-510	275	23	,	,	PUNCT
ecletica-510	275	24	m.	m.	NOUN
ecletica-510	275	25	;	;	PUNCT
ecletica-510	275	26	tsai	tsai	PROPN
ecletica-510	275	27	,	,	PUNCT
ecletica-510	275	28	l.	l.	PROPN
ecletica-510	275	29	h.	h.	PROPN
ecletica-510	275	30	;	;	PUNCT
ecletica-510	275	31	walter	walter	PROPN
ecletica-510	275	32	,	,	PUNCT
ecletica-510	275	33	j.	j.	PROPN
ecletica-510	275	34	;	;	PUNCT
ecletica-510	275	35	cleverley	cleverley	PROPN
ecletica-510	275	36	,	,	PUNCT
ecletica-510	275	37	k.	k.	PROPN
ecletica-510	275	38	e.	e.	PROPN
ecletica-510	275	39	;	;	PUNCT
ecletica-510	275	40	salinas	salinas	PROPN
ecletica-510	275	41	,	,	PUNCT
ecletica-510	275	42	p.	p.	PROPN
ecletica-510	275	43	c.	c.	PROPN
ecletica-510	275	44	;	;	PUNCT
ecletica-510	275	45	wu	wu	PROPN
ecletica-510	275	46	,	,	PUNCT
ecletica-510	275	47	y.	y.	PROPN
ecletica-510	275	48	z.	z.	PROPN
ecletica-510	275	49	;	;	PUNCT
ecletica-510	275	50	biernat	biernat	ADJ
ecletica-510	275	51	,	,	PUNCT
ecletica-510	275	52	j.	j.	PROPN
ecletica-510	275	53	;	;	PUNCT
ecletica-510	275	54	mandelkow	mandelkow	PROPN
ecletica-510	275	55	,	,	PUNCT
ecletica-510	275	56	e.	e.	PROPN
ecletica-510	275	57	m.	m.	PROPN
ecletica-510	275	58	;	;	PUNCT
ecletica-510	275	59	kim	kim	PROPN
ecletica-510	275	60	,	,	PUNCT
ecletica-510	275	61	s.-h	s.-h	NOUN
ecletica-510	275	62	.	.	PUNCT
ecletica-510	275	63	;	;	PUNCT
ecletica-510	275	64	pettit	pettit	PROPN
ecletica-510	275	65	,	,	PUNCT
ecletica-510	275	66	g.	g.	PROPN
ecletica-510	275	67	r.	r.	PROPN
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ecletica-510	275	69	of	of	ADP
ecletica-510	275	70	cyclin	cyclin	NOUN
ecletica-510	275	71	-	-	PUNCT
ecletica-510	275	72	dependent	dependent	ADJ
ecletica-510	275	73	kinases	kinase	NOUN
ecletica-510	275	74	,	,	PUNCT
ecletica-510	275	75	gsk-3beta	gsk-3beta	NOUN
ecletica-510	275	76	and	and	CCONJ
ecletica-510	275	77	ck1	ck1	PROPN
ecletica-510	275	78	by	by	ADP
ecletica-510	275	79	hymenialdisine	hymenialdisine	PROPN
ecletica-510	275	80	,	,	PUNCT
ecletica-510	275	81	a	a	DET
ecletica-510	275	82	marine	marine	ADJ
ecletica-510	275	83	sponge	sponge	NOUN
ecletica-510	275	84	constituent	constituent	NOUN
ecletica-510	275	85	.	.	PUNCT
ecletica-510	276	1	chem	chem	NOUN
ecletica-510	276	2	.	.	PUNCT
ecletica-510	277	1	biol	biol	PROPN
ecletica-510	277	2	.	.	PUNCT
ecletica-510	277	3	,	,	PUNCT
ecletica-510	277	4	v.	v.	ADV
ecletica-510	277	5	7	7	NUM
ecletica-510	277	6	,	,	PUNCT
ecletica-510	277	7	n.	n.	NOUN
ecletica-510	277	8	1	1	NUM
ecletica-510	277	9	,	,	PUNCT
ecletica-510	277	10	p.	p.	NOUN
ecletica-510	277	11	51	51	NUM
ecletica-510	277	12	-	-	SYM
ecletica-510	277	13	63	63	NUM
ecletica-510	277	14	,	,	PUNCT
ecletica-510	277	15	2000	2000	NUM
ecletica-510	277	16	.	.	PUNCT
ecletica-510	278	1	[	[	X
ecletica-510	278	2	30	30	NUM
ecletica-510	278	3	]	]	X
ecletica-510	278	4	nicholls	nicholls	PROPN
ecletica-510	278	5	,	,	PUNCT
ecletica-510	278	6	a.	a.	NOUN
ecletica-510	278	7	;	;	PUNCT
ecletica-510	278	8	sharp	sharp	ADJ
ecletica-510	278	9	,	,	PUNCT
ecletica-510	278	10	k.	k.	PROPN
ecletica-510	278	11	a.	a.	PROPN
ecletica-510	278	12	;	;	PUNCT
ecletica-510	278	13	honig	honig	PROPN
ecletica-510	278	14	,	,	PUNCT
ecletica-510	278	15	b.	b.	NOUN
ecletica-510	278	16	protein	protein	NOUN
ecletica-510	278	17	folding	folding	NOUN
ecletica-510	278	18	and	and	CCONJ
ecletica-510	278	19	association	association	NOUN
ecletica-510	278	20	:	:	PUNCT
ecletica-510	278	21	insights	insight	NOUN
ecletica-510	278	22	from	from	ADP
ecletica-510	278	23	the	the	DET
ecletica-510	278	24	interfacial	interfacial	ADJ
ecletica-510	278	25	and	and	CCONJ
ecletica-510	278	26	thermodynamic	thermodynamic	ADJ
ecletica-510	278	27	properties	property	NOUN
ecletica-510	278	28	of	of	ADP
ecletica-510	278	29	hydrocarbons	hydrocarbon	NOUN
ecletica-510	278	30	.	.	PUNCT
ecletica-510	279	1	proteins	protein	NOUN
ecletica-510	279	2	,	,	PUNCT
ecletica-510	279	3	v.	v.	ADP
ecletica-510	279	4	11	11	NUM
ecletica-510	279	5	,	,	PUNCT
ecletica-510	279	6	n.	n.	NOUN
ecletica-510	279	7	4	4	NUM
ecletica-510	279	8	,	,	PUNCT
ecletica-510	279	9	p.	p.	NOUN
ecletica-510	279	10	281	281	NUM
ecletica-510	279	11	-	-	SYM
ecletica-510	279	12	296	296	NUM
ecletica-510	279	13	,	,	PUNCT
ecletica-510	279	14	1991	1991	NUM
ecletica-510	279	15	.	.	PUNCT
ecletica-510	280	1	[	[	X
ecletica-510	280	2	31	31	NUM
ecletica-510	280	3	]	]	PUNCT
ecletica-510	280	4	norbury	norbury	PROPN
ecletica-510	280	5	,	,	PUNCT
ecletica-510	280	6	c.	c.	PROPN
ecletica-510	280	7	;	;	PUNCT
ecletica-510	280	8	nurse	nurse	NOUN
ecletica-510	280	9	,	,	PUNCT
ecletica-510	280	10	p.	p.	NOUN
ecletica-510	280	11	animal	animal	NOUN
ecletica-510	280	12	cell	cell	NOUN
ecletica-510	280	13	cycles	cycle	NOUN
ecletica-510	280	14	and	and	CCONJ
ecletica-510	280	15	their	their	PRON
ecletica-510	280	16	control	control	NOUN
ecletica-510	280	17	.	.	PUNCT
ecletica-510	281	1	annu	annu	PROPN
ecletica-510	281	2	.	.	PUNCT
ecletica-510	282	1	rev	rev	PROPN
ecletica-510	282	2	.	.	PROPN
ecletica-510	282	3	biochem	biochem	PROPN
ecletica-510	282	4	.	.	PUNCT
ecletica-510	282	5	,	,	PUNCT
ecletica-510	283	1	v.	v.	ADP
ecletica-510	283	2	61	61	NUM
ecletica-510	283	3	,	,	PUNCT
ecletica-510	283	4	p.	p.	NOUN
ecletica-510	283	5	441	441	NUM
ecletica-510	283	6	-	-	SYM
ecletica-510	283	7	470	470	NUM
ecletica-510	283	8	,	,	PUNCT
ecletica-510	283	9	1992	1992	NUM
ecletica-510	283	10	.	.	PUNCT
ecletica-510	284	1	[	[	X
ecletica-510	284	2	32	32	NUM
ecletica-510	284	3	]	]	SYM
ecletica-510	284	4	oikonomakos	oikonomakos	NOUN
ecletica-510	284	5	,	,	PUNCT
ecletica-510	284	6	n.	n.	PROPN
ecletica-510	284	7	g.	g.	PROPN
ecletica-510	284	8	;	;	PUNCT
ecletica-510	284	9	schnier	schnier	X
ecletica-510	284	10	,	,	PUNCT
ecletica-510	284	11	j.	j.	PROPN
ecletica-510	284	12	b.	b.	PROPN
ecletica-510	284	13	;	;	PUNCT
ecletica-510	284	14	zographos	zographos	NUM
ecletica-510	284	15	,	,	PUNCT
ecletica-510	284	16	s.	s.	PROPN
ecletica-510	284	17	e.	e.	PROPN
ecletica-510	284	18	;	;	PUNCT
ecletica-510	284	19	skamnaki	skamnaki	PROPN
ecletica-510	284	20	,	,	PUNCT
ecletica-510	284	21	v.	v.	PROPN
ecletica-510	284	22	t.	t.	PROPN
ecletica-510	284	23	;	;	PUNCT
ecletica-510	284	24	tsitsanou	tsitsanou	PROPN
ecletica-510	284	25	,	,	PUNCT
ecletica-510	284	26	k.	k.	PROPN
ecletica-510	284	27	e.	e.	PROPN
ecletica-510	284	28	;	;	PUNCT
ecletica-510	284	29	johnson	johnson	PROPN
ecletica-510	284	30	,	,	PUNCT
ecletica-510	284	31	l.	l.	PROPN
ecletica-510	284	32	n.	n.	PROPN
ecletica-510	284	33	flavopiridol	flavopiridol	PROPN
ecletica-510	284	34	inhibits	inhibit	VERB
ecletica-510	284	35	glycogen	glycogen	NOUN
ecletica-510	284	36	phosphorylase	phosphorylase	NOUN
ecletica-510	284	37	by	by	ADP
ecletica-510	284	38	binding	bind	VERB
ecletica-510	284	39	at	at	ADP
ecletica-510	284	40	the	the	DET
ecletica-510	284	41	inhibitor	inhibitor	NOUN
ecletica-510	284	42	site	site	NOUN
ecletica-510	284	43	.	.	PUNCT
ecletica-510	285	1	j.	j.	PROPN
ecletica-510	285	2	biol	biol	PROPN
ecletica-510	285	3	.	.	PUNCT
ecletica-510	286	1	chem	chem	PROPN
ecletica-510	286	2	.	.	PUNCT
ecletica-510	286	3	,	,	PUNCT
ecletica-510	287	1	v.	v.	ADP
ecletica-510	287	2	275	275	NUM
ecletica-510	287	3	,	,	PUNCT
ecletica-510	287	4	n.	n.	NOUN
ecletica-510	287	5	44	44	NUM
ecletica-510	287	6	,	,	PUNCT
ecletica-510	287	7	p.	p.	NOUN
ecletica-510	287	8	34566	34566	NUM
ecletica-510	287	9	-	-	SYM
ecletica-510	287	10	34573	34573	NUM
ecletica-510	287	11	,	,	PUNCT
ecletica-510	287	12	2000	2000	NUM
ecletica-510	287	13	.	.	PUNCT
ecletica-510	288	1	[	[	X
ecletica-510	288	2	33	33	NUM
ecletica-510	288	3	]	]	X
ecletica-510	288	4	patrick	patrick	PROPN
ecletica-510	288	5	,	,	PUNCT
ecletica-510	288	6	g.	g.	PROPN
ecletica-510	288	7	n.	n.	PROPN
ecletica-510	288	8	;	;	PUNCT
ecletica-510	288	9	zukerberg	zukerberg	PROPN
ecletica-510	288	10	,	,	PUNCT
ecletica-510	288	11	l.	l.	PROPN
ecletica-510	288	12	;	;	PUNCT
ecletica-510	288	13	nikolic	nikolic	PROPN
ecletica-510	288	14	,	,	PUNCT
ecletica-510	288	15	m.	m.	NOUN
ecletica-510	288	16	;	;	PUNCT
ecletica-510	288	17	de	de	X
ecletica-510	288	18	la	la	X
ecletica-510	288	19	monte	monte	PROPN
ecletica-510	288	20	,	,	PUNCT
ecletica-510	288	21	s.	s.	PROPN
ecletica-510	288	22	;	;	PUNCT
ecletica-510	288	23	dikkes	dikke	NOUN
ecletica-510	288	24	,	,	PUNCT
ecletica-510	288	25	p.	p.	PROPN
ecletica-510	288	26	;	;	PUNCT
ecletica-510	288	27	tsai	tsai	PROPN
ecletica-510	288	28	,	,	PUNCT
ecletica-510	288	29	l.	l.	PROPN
ecletica-510	288	30	h.	h.	PROPN
ecletica-510	288	31	conversion	conversion	PROPN
ecletica-510	288	32	of	of	ADP
ecletica-510	288	33	p35	p35	NOUN
ecletica-510	288	34	to	to	ADP
ecletica-510	288	35	p25	p25	NOUN
ecletica-510	288	36	deregulates	deregulate	VERB
ecletica-510	288	37	cdk5	cdk5	NOUN
ecletica-510	288	38	activity	activity	NOUN
ecletica-510	288	39	and	and	CCONJ
ecletica-510	288	40	promotes	promote	VERB
ecletica-510	288	41	neurodegeneration	neurodegeneration	NOUN
ecletica-510	288	42	.	.	PUNCT
ecletica-510	289	1	nature	nature	NOUN
ecletica-510	289	2	,	,	PUNCT
ecletica-510	289	3	v.	v.	ADP
ecletica-510	289	4	402	402	NUM
ecletica-510	289	5	,	,	PUNCT
ecletica-510	289	6	n.	n.	NOUN
ecletica-510	289	7	6762	6762	NUM
ecletica-510	289	8	,	,	PUNCT
ecletica-510	289	9	p.	p.	NOUN
ecletica-510	289	10	615	615	NUM
ecletica-510	289	11	-	-	SYM
ecletica-510	289	12	22	22	NUM
ecletica-510	289	13	,	,	PUNCT
ecletica-510	289	14	1999	1999	NUM
ecletica-510	289	15	.	.	PUNCT
ecletica-510	290	1	[	[	X
ecletica-510	290	2	34	34	NUM
ecletica-510	290	3	]	]	X
ecletica-510	290	4	richardson	richardson	PROPN
ecletica-510	290	5	,	,	PUNCT
ecletica-510	290	6	h.	h.	PROPN
ecletica-510	290	7	e.	e.	PROPN
ecletica-510	290	8	;	;	PUNCT
ecletica-510	290	9	stueland	stueland	PROPN
ecletica-510	290	10	,	,	PUNCT
ecletica-510	290	11	c.	c.	PROPN
ecletica-510	290	12	s.	s.	PROPN
ecletica-510	290	13	;	;	PUNCT
ecletica-510	290	14	thomas	thomas	PROPN
ecletica-510	290	15	,	,	PUNCT
ecletica-510	290	16	j.	j.	PROPN
ecletica-510	290	17	;	;	PUNCT
ecletica-510	290	18	russel	russel	PROPN
ecletica-510	290	19	,	,	PUNCT
ecletica-510	290	20	p.	p.	PROPN
ecletica-510	290	21	;	;	PUNCT
ecletica-510	290	22	reed	reed	PROPN
ecletica-510	290	23	,	,	PUNCT
ecletica-510	290	24	s.	s.	PROPN
ecletica-510	290	25	i.	i.	PROPN
ecletica-510	290	26	human	human	PROPN
ecletica-510	290	27	cdnas	cdnas	PROPN
ecletica-510	290	28	encoding	encode	VERB
ecletica-510	290	29	homologs	homolog	NOUN
ecletica-510	290	30	of	of	ADP
ecletica-510	290	31	the	the	DET
ecletica-510	290	32	small	small	ADJ
ecletica-510	290	33	p34cdc28	p34cdc28	NOUN
ecletica-510	290	34	/	/	SYM
ecletica-510	290	35	cdc2	cdc2	NOUN
ecletica-510	290	36	-	-	PUNCT
ecletica-510	290	37	associated	associate	VERB
ecletica-510	290	38	protein	protein	NOUN
ecletica-510	290	39	of	of	ADP
ecletica-510	290	40	saccharomyces	saccharomyce	NOUN
ecletica-510	290	41	cerevisiae	cerevisiae	NOUN
ecletica-510	290	42	and	and	CCONJ
ecletica-510	290	43	schizosaccharomyces	schizosaccharomyce	NOUN
ecletica-510	290	44	pombe	pombe	NOUN
ecletica-510	290	45	.	.	PUNCT
ecletica-510	291	1	genes	gene	NOUN
ecletica-510	291	2	dev	dev	PROPN
ecletica-510	291	3	.	.	PROPN
ecletica-510	291	4	,	,	PUNCT
ecletica-510	291	5	v.	v.	ADP
ecletica-510	291	6	4	4	NUM
ecletica-510	291	7	,	,	PUNCT
ecletica-510	291	8	p.	p.	NOUN
ecletica-510	291	9	1332	1332	NUM
ecletica-510	291	10	-	-	SYM
ecletica-510	291	11	1344	1344	NUM
ecletica-510	291	12	,	,	PUNCT
ecletica-510	291	13	1990	1990	NUM
ecletica-510	291	14	.	.	PUNCT
ecletica-510	292	1	[	[	X
ecletica-510	292	2	35	35	NUM
ecletica-510	292	3	]	]	X
ecletica-510	292	4	sali	sali	X
ecletica-510	292	5	,	,	PUNCT
ecletica-510	292	6	a.	a.	NOUN
ecletica-510	292	7	modeling	modeling	NOUN
ecletica-510	292	8	mutations	mutation	NOUN
ecletica-510	292	9	and	and	CCONJ
ecletica-510	292	10	homologous	homologous	ADJ
ecletica-510	292	11	proteins	protein	NOUN
ecletica-510	292	12	.	.	PUNCT
ecletica-510	293	1	curr	curr	PROPN
ecletica-510	293	2	.	.	PUNCT
ecletica-510	294	1	opin	opin	NOUN
ecletica-510	294	2	.	.	PUNCT
ecletica-510	295	1	biotechnol	biotechnol	PROPN
ecletica-510	295	2	.	.	PUNCT
ecletica-510	295	3	,	,	PUNCT
ecletica-510	296	1	v.	v.	ADP
ecletica-510	296	2	6	6	NUM
ecletica-510	296	3	,	,	PUNCT
ecletica-510	296	4	n.	n.	NOUN
ecletica-510	296	5	4	4	NUM
ecletica-510	296	6	,	,	PUNCT
ecletica-510	296	7	p.	p.	NOUN
ecletica-510	296	8	437	437	NUM
ecletica-510	296	9	-	-	SYM
ecletica-510	296	10	451	451	NUM
ecletica-510	296	11	,	,	PUNCT
ecletica-510	296	12	1995	1995	NUM
ecletica-510	296	13	.	.	PUNCT
ecletica-510	297	1	[	[	X
ecletica-510	297	2	36	36	NUM
ecletica-510	297	3	]	]	X
ecletica-510	297	4	sali	sali	X
ecletica-510	297	5	,	,	PUNCT
ecletica-510	297	6	a.	a.	NOUN
ecletica-510	297	7	;	;	PUNCT
ecletica-510	297	8	blundell	blundell	PROPN
ecletica-510	297	9	,	,	PUNCT
ecletica-510	297	10	t.	t.	PROPN
ecletica-510	297	11	l.	l.	PROPN
ecletica-510	297	12	comparative	comparative	ADJ
ecletica-510	297	13	protein	protein	NOUN
ecletica-510	297	14	modelling	modelling	NOUN
ecletica-510	297	15	by	by	ADP
ecletica-510	297	16	satisfaction	satisfaction	NOUN
ecletica-510	297	17	of	of	ADP
ecletica-510	297	18	spatial	spatial	ADJ
ecletica-510	297	19	restraints	restraint	NOUN
ecletica-510	297	20	.	.	PUNCT
ecletica-510	298	1	j.	j.	PROPN
ecletica-510	298	2	mol	mol	PROPN
ecletica-510	298	3	.	.	PUNCT
ecletica-510	299	1	biol	biol	PROPN
ecletica-510	299	2	.	.	PUNCT
ecletica-510	299	3	,	,	PUNCT
ecletica-510	299	4	v.	v.	ADP
ecletica-510	299	5	234	234	NUM
ecletica-510	299	6	,	,	PUNCT
ecletica-510	299	7	p.	p.	NOUN
ecletica-510	299	8	779	779	NUM
ecletica-510	299	9	-	-	SYM
ecletica-510	299	10	815	815	NUM
ecletica-510	299	11	,	,	PUNCT
ecletica-510	299	12	1993	1993	NUM
ecletica-510	299	13	.	.	PUNCT
ecletica-510	300	1	[	[	X
ecletica-510	300	2	37	37	NUM
ecletica-510	300	3	]	]	X
ecletica-510	300	4	sali	sali	X
ecletica-510	300	5	,	,	PUNCT
ecletica-510	300	6	a.	a.	NOUN
ecletica-510	300	7	;	;	PUNCT
ecletica-510	300	8	overington	overington	NOUN
ecletica-510	300	9	,	,	PUNCT
ecletica-510	300	10	j.	j.	PROPN
ecletica-510	300	11	p.	p.	PROPN
ecletica-510	300	12	derivation	derivation	NOUN
ecletica-510	300	13	of	of	ADP
ecletica-510	300	14	rules	rule	NOUN
ecletica-510	300	15	for	for	ADP
ecletica-510	300	16	comparative	comparative	ADJ
ecletica-510	300	17	protein	protein	NOUN
ecletica-510	300	18	modeling	modeling	NOUN
ecletica-510	300	19	from	from	ADP
ecletica-510	300	20	a	a	DET
ecletica-510	300	21	database	database	NOUN
ecletica-510	300	22	of	of	ADP
ecletica-510	300	23	protein	protein	NOUN
ecletica-510	300	24	structure	structure	NOUN
ecletica-510	300	25	alignments	alignment	NOUN
ecletica-510	300	26	.	.	PUNCT
ecletica-510	301	1	protein	protein	NOUN
ecletica-510	301	2	sci	sci	PROPN
ecletica-510	301	3	.	.	PROPN
ecletica-510	301	4	,	,	PUNCT
ecletica-510	301	5	v.	v.	ADP
ecletica-510	301	6	3	3	NUM
ecletica-510	301	7	,	,	PUNCT
ecletica-510	301	8	n.	n.	NOUN
ecletica-510	301	9	9	9	NUM
ecletica-510	301	10	,	,	PUNCT
ecletica-510	301	11	p.	p.	NOUN
ecletica-510	301	12	1582	1582	NUM
ecletica-510	301	13	-	-	SYM
ecletica-510	301	14	1596	1596	NUM
ecletica-510	301	15	,	,	PUNCT
ecletica-510	301	16	1994	1994	NUM
ecletica-510	301	17	.	.	PUNCT
ecletica-510	302	1	[	[	X
ecletica-510	302	2	38	38	NUM
ecletica-510	302	3	]	]	X
ecletica-510	302	4	sali	sali	X
ecletica-510	302	5	,	,	PUNCT
ecletica-510	302	6	a.	a.	NOUN
ecletica-510	302	7	;	;	PUNCT
ecletica-510	302	8	potterton	potterton	PROPN
ecletica-510	302	9	,	,	PUNCT
ecletica-510	302	10	l.	l.	PROPN
ecletica-510	302	11	;	;	PUNCT
ecletica-510	302	12	yuan	yuan	PROPN
ecletica-510	302	13	,	,	PUNCT
ecletica-510	302	14	f.	f.	PROPN
ecletica-510	302	15	;	;	PUNCT
ecletica-510	302	16	van	van	PROPN
ecletica-510	302	17	vlijmen	vlijmen	PROPN
ecletica-510	302	18	,	,	PUNCT
ecletica-510	302	19	h.	h.	PROPN
ecletica-510	302	20	;	;	PUNCT
ecletica-510	302	21	karplus	karplus	ADJ
ecletica-510	302	22	,	,	PUNCT
ecletica-510	302	23	m.	m.	NOUN
ecletica-510	302	24	evaluation	evaluation	NOUN
ecletica-510	302	25	of	of	ADP
ecletica-510	302	26	comparative	comparative	ADJ
ecletica-510	302	27	protein	protein	NOUN
ecletica-510	302	28	modeling	modeling	NOUN
ecletica-510	302	29	by	by	ADP
ecletica-510	302	30	modeller	modeller	NOUN
ecletica-510	302	31	.	.	PUNCT
ecletica-510	303	1	proteins	protein	NOUN
ecletica-510	303	2	,	,	PUNCT
ecletica-510	303	3	v.	v.	ADP
ecletica-510	303	4	23	23	NUM
ecletica-510	303	5	,	,	PUNCT
ecletica-510	303	6	n.	n.	NOUN
ecletica-510	303	7	3	3	NUM
ecletica-510	303	8	,	,	PUNCT
ecletica-510	303	9	p.	p.	NOUN
ecletica-510	303	10	318	318	NUM
ecletica-510	303	11	-	-	SYM
ecletica-510	303	12	326	326	NUM
ecletica-510	303	13	,	,	PUNCT
ecletica-510	303	14	1995	1995	NUM
ecletica-510	303	15	.	.	PUNCT
ecletica-510	304	1	[	[	X
ecletica-510	304	2	39	39	NUM
ecletica-510	304	3	]	]	PUNCT
ecletica-510	304	4	schultze	schultze	NOUN
ecletica-510	304	5	-	-	PUNCT
ecletica-510	304	6	gahmen	gahmen	PROPN
ecletica-510	304	7	,	,	PUNCT
ecletica-510	304	8	u.	u.	PROPN
ecletica-510	304	9	;	;	PUNCT
ecletica-510	304	10	brandsen	brandsen	PROPN
ecletica-510	304	11	,	,	PUNCT
ecletica-510	304	12	j.	j.	PROPN
ecletica-510	304	13	;	;	PUNCT
ecletica-510	304	14	jones	jones	PROPN
ecletica-510	304	15	,	,	PUNCT
ecletica-510	304	16	h.	h.	PROPN
ecletica-510	304	17	d.	d.	PROPN
ecletica-510	304	18	;	;	PUNCT
ecletica-510	304	19	morgan	morgan	PROPN
ecletica-510	304	20	,	,	PUNCT
ecletica-510	304	21	d.	d.	PROPN
ecletica-510	304	22	o.	o.	PROPN
ecletica-510	304	23	;	;	PUNCT
ecletica-510	304	24	meijer	meijer	PROPN
ecletica-510	304	25	,	,	PUNCT
ecletica-510	304	26	i.	i.	PROPN
ecletica-510	304	27	;	;	PUNCT
ecletica-510	304	28	vesely	vesely	PROPN
ecletica-510	304	29	,	,	PUNCT
ecletica-510	304	30	j.	j.	PROPN
ecletica-510	304	31	multiple	multiple	PROPN
ecletica-510	304	32	modes	mode	NOUN
ecletica-510	304	33	of	of	ADP
ecletica-510	304	34	ligand	ligand	ADJ
ecletica-510	304	35	recognition	recognition	NOUN
ecletica-510	304	36	:	:	PUNCT
ecletica-510	304	37	crystal	crystal	NOUN
ecletica-510	304	38	structures	structure	NOUN
ecletica-510	304	39	of	of	ADP
ecletica-510	304	40	cyclindependent	cyclindependent	ADJ
ecletica-510	304	41	protein	protein	NOUN
ecletica-510	304	42	kinase	kinase	NOUN
ecletica-510	304	43	2	2	NUM
ecletica-510	304	44	in	in	ADP
ecletica-510	304	45	the	the	DET
ecletica-510	304	46	complex	complex	NOUN
ecletica-510	304	47	with	with	ADP
ecletica-510	304	48	atp	atp	PROPN
ecletica-510	304	49	and	and	CCONJ
ecletica-510	304	50	two	two	NUM
ecletica-510	304	51	inhibitors	inhibitor	NOUN
ecletica-510	304	52	,	,	PUNCT
ecletica-510	304	53	olomoucine	olomoucine	NOUN
ecletica-510	304	54	and	and	CCONJ
ecletica-510	304	55	isopentenyladenine	isopentenyladenine	NOUN
ecletica-510	304	56	.	.	PUNCT
ecletica-510	305	1	proteins	protein	NOUN
ecletica-510	305	2	,	,	PUNCT
ecletica-510	305	3	v.	v.	ADP
ecletica-510	305	4	22	22	NUM
ecletica-510	305	5	,	,	PUNCT
ecletica-510	305	6	p.	p.	NOUN
ecletica-510	305	7	378	378	NUM
ecletica-510	305	8	-	-	SYM
ecletica-510	305	9	391	391	NUM
ecletica-510	305	10	,	,	PUNCT
ecletica-510	305	11	1995	1995	NUM
ecletica-510	305	12	.	.	PUNCT
ecletica-510	306	1	[	[	X
ecletica-510	306	2	40	40	NUM
ecletica-510	306	3	]	]	PUNCT
ecletica-510	306	4	senderowicz	senderowicz	ADV
ecletica-510	306	5	,	,	PUNCT
ecletica-510	306	6	a.	a.	NOUN
ecletica-510	306	7	m.	m.	NOUN
ecletica-510	306	8	;	;	PUNCT
ecletica-510	307	1	sausville	sausville	PROPN
ecletica-510	307	2	,	,	PUNCT
ecletica-510	307	3	e.	e.	PROPN
ecletica-510	307	4	a.	a.	PROPN
ecletica-510	307	5	preclinical	preclinical	PROPN
ecletica-510	307	6	and	and	CCONJ
ecletica-510	307	7	clinical	clinical	ADJ
ecletica-510	307	8	development	development	NOUN
ecletica-510	307	9	of	of	ADP
ecletica-510	307	10	cyclin	cyclin	NOUN
ecletica-510	307	11	-	-	PUNCT
ecletica-510	307	12	dependent	dependent	ADJ
ecletica-510	307	13	kinase	kinase	NOUN
ecletica-510	307	14	modulators	modulator	NOUN
ecletica-510	307	15	.	.	PUNCT
ecletica-510	308	1	j.	j.	PROPN
ecletica-510	308	2	natl	natl	PROPN
ecletica-510	308	3	.	.	PUNCT
ecletica-510	308	4	cancer	cancer	NOUN
ecletica-510	308	5	inst	inst	PROPN
ecletica-510	308	6	.	.	PROPN
ecletica-510	308	7	,	,	PUNCT
ecletica-510	308	8	v.	v.	ADP
ecletica-510	308	9	92	92	NUM
ecletica-510	308	10	,	,	PUNCT
ecletica-510	308	11	n.	n.	NOUN
ecletica-510	308	12	5	5	NUM
ecletica-510	308	13	,	,	PUNCT
ecletica-510	308	14	p.	p.	NOUN
ecletica-510	308	15	376	376	NUM
ecletica-510	308	16	-	-	SYM
ecletica-510	308	17	387	387	NUM
ecletica-510	308	18	,	,	PUNCT
ecletica-510	308	19	2000	2000	NUM
ecletica-510	308	20	.	.	PUNCT
ecletica-510	309	1	[	[	X
ecletica-510	309	2	41	41	NUM
ecletica-510	309	3	]	]	PUNCT
ecletica-510	309	4	serota	serota	PROPN
ecletica-510	309	5	,	,	PUNCT
ecletica-510	309	6	s.	s.	PROPN
ecletica-510	309	7	;	;	PUNCT
ecletica-510	309	8	radsio	radsio	NOUN
ecletica-510	309	9	-	-	PUNCT
ecletica-510	309	10	andzelm	andzelm	PROPN
ecletica-510	309	11	,	,	PUNCT
ecletica-510	309	12	e.	e.	PROPN
ecletica-510	309	13	three	three	NUM
ecletica-510	309	14	protein	protein	NOUN
ecletica-510	309	15	kinase	kinase	PROPN
ecletica-510	309	16	structures	structure	NOUN
ecletica-510	309	17	define	define	VERB
ecletica-510	309	18	a	a	DET
ecletica-510	309	19	common	common	ADJ
ecletica-510	309	20	motif	motif	NOUN
ecletica-510	309	21	.	.	PUNCT
ecletica-510	310	1	structure	structure	NOUN
ecletica-510	310	2	,	,	PUNCT
ecletica-510	310	3	v.	v.	ADP
ecletica-510	310	4	2	2	NUM
ecletica-510	310	5	,	,	PUNCT
ecletica-510	310	6	p.	p.	NOUN
ecletica-510	310	7	345	345	NUM
ecletica-510	310	8	-	-	SYM
ecletica-510	310	9	355	355	NUM
ecletica-510	310	10	,	,	PUNCT
ecletica-510	310	11	1994	1994	NUM
ecletica-510	310	12	.	.	PUNCT
ecletica-510	311	1	ecl	ecl	PROPN
ecletica-510	311	2	.	.	PROPN
ecletica-510	311	3	quím	quím	PROPN
ecletica-510	311	4	.	.	PUNCT
ecletica-510	311	5	,	,	PUNCT
ecletica-510	311	6	são	são	PROPN
ecletica-510	311	7	paulo	paulo	PROPN
ecletica-510	311	8	,	,	PUNCT
ecletica-510	311	9	28(1	28(1	NOUN
ecletica-510	311	10	):	):	PUNCT
ecletica-510	311	11	45	45	NUM
ecletica-510	311	12	-	-	SYM
ecletica-510	311	13	53	53	NUM
ecletica-510	311	14	,	,	PUNCT
ecletica-510	311	15	2003	2003	NUM