id	sid	tid	token	lemma	pos
easat-249	1	1	edelweiss	edelweiss	PROPN
easat-249	1	2	applied	apply	VERB
easat-249	1	3	science	science	NOUN
easat-249	1	4	and	and	CCONJ
easat-249	1	5	technology	technology	NOUN
easat-249	1	6	issn	issn	PROPN
easat-249	1	7	:	:	PUNCT
easat-249	1	8	2576	2576	NUM
easat-249	1	9	-	-	SYM
easat-249	1	10	8484	8484	NUM
easat-249	1	11	vol	vol	NOUN
easat-249	1	12	.	.	PROPN
easat-249	2	1	2	2	NUM
easat-249	2	2	,	,	PUNCT
easat-249	2	3	no	no	INTJ
easat-249	2	4	.	.	NOUN
easat-249	2	5	1	1	NUM
easat-249	2	6	,	,	PUNCT
easat-249	2	7	232	232	NUM
easat-249	2	8	-	-	SYM
easat-249	2	9	233	233	NUM
easat-249	2	10	2018	2018	NUM
easat-249	2	11	doi	doi	NOUN
easat-249	2	12	:	:	PUNCT
easat-249	2	13	10.33805/2576	10.33805/2576	NUM
easat-249	2	14	-	-	SYM
easat-249	2	15	8484.144	8484.144	NUM
easat-249	2	16	©	©	PROPN
easat-249	2	17	2018	2018	NUM
easat-249	2	18	by	by	ADP
easat-249	2	19	the	the	DET
easat-249	2	20	author	author	NOUN
easat-249	2	21	©	©	PROPN
easat-249	2	22	2018	2018	NUM
easat-249	2	23	by	by	ADP
easat-249	2	24	the	the	DET
easat-249	2	25	author	author	NOUN
easat-249	2	26	history	history	NOUN
easat-249	2	27	:	:	PUNCT
easat-249	2	28	received	receive	VERB
easat-249	2	29	:	:	PUNCT
easat-249	2	30	2	2	NUM
easat-249	2	31	may	may	PROPN
easat-249	2	32	2018	2018	NUM
easat-249	2	33	;	;	PUNCT
easat-249	2	34	accepted	accept	VERB
easat-249	2	35	:	:	PUNCT
easat-249	2	36	16	16	NUM
easat-249	2	37	may	may	PROPN
easat-249	2	38	2018	2018	NUM
easat-249	2	39	;	;	PUNCT
easat-249	2	40	published	publish	VERB
easat-249	2	41	:	:	PUNCT
easat-249	2	42	21	21	NUM
easat-249	2	43	may	may	PROPN
easat-249	2	44	2018	2018	NUM
easat-249	2	45	unique	unique	ADJ
easat-249	2	46	case	case	NOUN
easat-249	2	47	of	of	ADP
easat-249	2	48	alpha	alpha	ADJ
easat-249	2	49	1	1	NUM
easat-249	2	50	-	-	PUNCT
easat-249	2	51	antitrypsin	antitrypsin	NOUN
easat-249	2	52	deficiency	deficiency	NOUN
easat-249	2	53	causing	cause	VERB
easat-249	2	54	decreased	decrease	VERB
easat-249	2	55	proteinc	proteinc	NOUN
easat-249	2	56	and	and	CCONJ
easat-249	2	57	s	s	NOUN
easat-249	2	58	activity	activity	NOUN
easat-249	2	59	leading	lead	VERB
easat-249	2	60	to	to	ADP
easat-249	2	61	dvt	dvt	PROPN
easat-249	2	62	and	and	CCONJ
easat-249	2	63	pulmonary	pulmonary	ADJ
easat-249	2	64	embolism	embolism	NOUN
easat-249	2	65	manoj	manoj	VERB
easat-249	2	66	singla	singla	NOUN
easat-249	2	67	reading	read	VERB
easat-249	2	68	hospital	hospital	NOUN
easat-249	2	69	and	and	CCONJ
easat-249	2	70	medical	medical	ADJ
easat-249	2	71	center	center	NOUN
easat-249	2	72	,	,	PUNCT
easat-249	2	73	pennsylvania	pennsylvania	PROPN
easat-249	2	74	,	,	PUNCT
easat-249	2	75	usa	usa	PROPN
easat-249	2	76	.	.	PROPN
easat-249	2	77	abstract	abstract	PROPN
easat-249	2	78	:	:	PUNCT
easat-249	2	79	although	although	SCONJ
easat-249	2	80	alpha-1	alpha-1	NUM
easat-249	2	81	antitrypsin	antitrypsin	NOUN
easat-249	2	82	deficiency	deficiency	NOUN
easat-249	2	83	(	(	PUNCT
easat-249	2	84	aatd	aatd	NOUN
easat-249	2	85	)	)	PUNCT
easat-249	2	86	is	be	AUX
easat-249	2	87	generally	generally	ADV
easat-249	2	88	considered	consider	VERB
easat-249	2	89	to	to	PART
easat-249	2	90	be	be	AUX
easat-249	2	91	rare	rare	ADJ
easat-249	2	92	,	,	PUNCT
easat-249	2	93	estimates	estimate	VERB
easat-249	2	94	that	that	SCONJ
easat-249	2	95	80,000	80,000	NUM
easat-249	2	96	to	to	PART
easat-249	2	97	100,000	100,000	NUM
easat-249	2	98	individuals	individual	NOUN
easat-249	2	99	in	in	ADP
easat-249	2	100	the	the	DET
easat-249	2	101	united	united	PROPN
easat-249	2	102	states	states	PROPN
easat-249	2	103	have	have	VERB
easat-249	2	104	severe	severe	ADJ
easat-249	2	105	deficiency	deficiency	NOUN
easat-249	2	106	of	of	ADP
easat-249	2	107	aat	aat	PROPN
easat-249	2	108	suggest	suggest	VERB
easat-249	2	109	that	that	SCONJ
easat-249	2	110	the	the	DET
easat-249	2	111	disease	disease	NOUN
easat-249	2	112	is	be	AUX
easat-249	2	113	underrecognized	underrecognized	ADJ
easat-249	2	114	[	[	X
easat-249	2	115	1,2	1,2	NUM
easat-249	2	116	]	]	PUNCT
easat-249	2	117	.	.	PUNCT
easat-249	3	1	the	the	DET
easat-249	3	2	prevalence	prevalence	NOUN
easat-249	3	3	of	of	ADP
easat-249	3	4	aat	aat	PROPN
easat-249	3	5	varies	vary	VERB
easat-249	3	6	considerably	considerably	ADV
easat-249	3	7	from	from	ADP
easat-249	3	8	one	one	NUM
easat-249	3	9	country	country	NOUN
easat-249	3	10	to	to	ADP
easat-249	3	11	another	another	PRON
easat-249	3	12	[	[	X
easat-249	3	13	3	3	NUM
easat-249	3	14	]	]	PUNCT
easat-249	3	15	;	;	PUNCT
easat-249	3	16	however	however	ADV
easat-249	3	17	,	,	PUNCT
easat-249	3	18	it	it	PRON
easat-249	3	19	is	be	AUX
easat-249	3	20	estimated	estimate	VERB
easat-249	3	21	that	that	SCONJ
easat-249	3	22	more	more	ADJ
easat-249	3	23	than	than	ADP
easat-249	3	24	3	3	NUM
easat-249	3	25	million	million	NUM
easat-249	3	26	people	people	NOUN
easat-249	3	27	worldwide	worldwide	ADV
easat-249	3	28	have	have	VERB
easat-249	3	29	allele	allele	NOUN
easat-249	3	30	combinations	combination	NOUN
easat-249	3	31	associated	associate	VERB
easat-249	3	32	with	with	ADP
easat-249	3	33	severe	severe	ADJ
easat-249	3	34	deficiency	deficiency	NOUN
easat-249	3	35	of	of	ADP
easat-249	3	36	aat	aat	NOUN
easat-249	4	1	[	[	X
easat-249	4	2	4,5	4,5	NUM
easat-249	4	3	]	]	PUNCT
easat-249	4	4	.	.	PUNCT
easat-249	5	1	the	the	DET
easat-249	5	2	pathogenesis	pathogenesis	NOUN
easat-249	5	3	of	of	ADP
easat-249	5	4	the	the	DET
easat-249	5	5	liver	liver	NOUN
easat-249	5	6	disease	disease	NOUN
easat-249	5	7	is	be	AUX
easat-249	5	8	quite	quite	ADV
easat-249	5	9	different	different	ADJ
easat-249	5	10	and	and	CCONJ
easat-249	5	11	is	be	AUX
easat-249	5	12	called	call	VERB
easat-249	5	13	a	a	DET
easat-249	5	14	"	"	PUNCT
easat-249	5	15	toxic	toxic	ADJ
easat-249	5	16	gain	gain	NOUN
easat-249	5	17	of	of	ADP
easat-249	5	18	function	function	NOUN
easat-249	5	19	.	.	PUNCT
easat-249	5	20	"	"	PUNCT
easat-249	6	1	the	the	DET
easat-249	6	2	liver	liver	NOUN
easat-249	6	3	disease	disease	NOUN
easat-249	6	4	results	result	VERB
easat-249	6	5	from	from	ADP
easat-249	6	6	the	the	DET
easat-249	6	7	accumulation	accumulation	NOUN
easat-249	6	8	within	within	ADP
easat-249	6	9	the	the	DET
easat-249	6	10	hepatocyte	hepatocyte	NOUN
easat-249	6	11	of	of	ADP
easat-249	6	12	unsecreted	unsecreted	ADJ
easat-249	6	13	variant	variant	ADJ
easat-249	6	14	aat	aat	X
easat-249	6	15	protein	protein	NOUN
easat-249	6	16	.	.	PUNCT
easat-249	7	1	only	only	ADV
easat-249	7	2	those	those	DET
easat-249	7	3	genotypes	genotype	NOUN
easat-249	7	4	associated	associate	VERB
easat-249	7	5	with	with	ADP
easat-249	7	6	pathologic	pathologic	ADJ
easat-249	7	7	polymerization	polymerization	NOUN
easat-249	7	8	of	of	ADP
easat-249	7	9	aat	aat	NOUN
easat-249	7	10	within	within	ADP
easat-249	7	11	the	the	DET
easat-249	7	12	endoplasmic	endoplasmic	ADJ
easat-249	7	13	reticulum	reticulum	NOUN
easat-249	7	14	of	of	ADP
easat-249	7	15	hepatocytes	hepatocyte	NOUN
easat-249	7	16	(	(	PUNCT
easat-249	7	17	eg	eg	NOUN
easat-249	7	18	,	,	PUNCT
easat-249	7	19	pi*zz	pi*zz	NOUN
easat-249	7	20	type	type	NOUN
easat-249	7	21	aatd	aatd	PROPN
easat-249	7	22	)	)	PUNCT
easat-249	7	23	produce	produce	VERB
easat-249	7	24	disease	disease	NOUN
easat-249	7	25	[	[	X
easat-249	7	26	6	6	NUM
easat-249	7	27	-	-	SYM
easat-249	7	28	8	8	NUM
easat-249	7	29	]	]	PUNCT
easat-249	7	30	.	.	PUNCT
easat-249	8	1	most	most	ADJ
easat-249	8	2	patients	patient	NOUN
easat-249	8	3	with	with	ADP
easat-249	8	4	liver	liver	NOUN
easat-249	8	5	disease	disease	NOUN
easat-249	8	6	due	due	ADP
easat-249	8	7	to	to	ADP
easat-249	8	8	aatd	aatd	PROPN
easat-249	8	9	are	be	AUX
easat-249	8	10	homozygous	homozygous	ADJ
easat-249	8	11	for	for	ADP
easat-249	8	12	the	the	DET
easat-249	8	13	z	z	NOUN
easat-249	8	14	allele	allele	NOUN
easat-249	8	15	(	(	PUNCT
easat-249	8	16	ie	ie	X
easat-249	8	17	,	,	PUNCT
easat-249	8	18	pi*zz	pi*zz	NOUN
easat-249	8	19	)	)	PUNCT
easat-249	8	20	;	;	PUNCT
easat-249	8	21	liver	liver	NOUN
easat-249	8	22	disease	disease	NOUN
easat-249	8	23	does	do	AUX
easat-249	8	24	not	not	PART
easat-249	8	25	occur	occur	VERB
easat-249	8	26	in	in	ADP
easat-249	8	27	null	null	ADJ
easat-249	8	28	homozygotes	homozygote	NOUN
easat-249	8	29	who	who	PRON
easat-249	8	30	have	have	VERB
easat-249	8	31	severe	severe	ADJ
easat-249	8	32	deficiency	deficiency	NOUN
easat-249	8	33	of	of	ADP
easat-249	8	34	aat	aat	NOUN
easat-249	8	35	,	,	PUNCT
easat-249	8	36	but	but	CCONJ
easat-249	8	37	no	no	DET
easat-249	8	38	intra	intra	ADJ
easat-249	8	39	-	-	ADJ
easat-249	8	40	hepatocytic	hepatocytic	ADJ
easat-249	8	41	accumulation	accumulation	NOUN
easat-249	8	42	.	.	PUNCT
easat-249	9	1	keywords	keyword	NOUN
easat-249	9	2	:	:	PUNCT
easat-249	9	3	alpha	alpha	NOUN
easat-249	9	4	1	1	NUM
easat-249	9	5	-	-	PUNCT
easat-249	9	6	antitrypsin	antitrypsin	NOUN
easat-249	9	7	deficiency	deficiency	NOUN
easat-249	9	8	,	,	PUNCT
easat-249	9	9	liver	liver	NOUN
easat-249	9	10	cirrhosis	cirrhosis	NOUN
easat-249	9	11	,	,	PUNCT
easat-249	9	12	protein	protein	NOUN
easat-249	9	13	c	c	NOUN
easat-249	9	14	,	,	PUNCT
easat-249	9	15	protein	protein	NOUN
easat-249	9	16	s	s	NOUN
easat-249	9	17	,	,	PUNCT
easat-249	9	18	pulmonary	pulmonary	ADJ
easat-249	9	19	embolism	embolism	NOUN
easat-249	9	20	,	,	PUNCT
easat-249	9	21	dvt	dvt	PROPN
easat-249	9	22	.	.	PROPN
easat-249	9	23	1	1	NUM
easat-249	9	24	.	.	X
easat-249	9	25	case	case	NOUN
easat-249	9	26	report	report	VERB
easat-249	9	27	62	62	NUM
easat-249	9	28	-year	-year	NOUN
easat-249	9	29	-	-	PUNCT
easat-249	9	30	old	old	ADJ
easat-249	9	31	,	,	PUNCT
easat-249	9	32	non	non	ADJ
easat-249	9	33	-	-	ADJ
easat-249	9	34	smoking	smoking	ADJ
easat-249	9	35	,	,	PUNCT
easat-249	9	36	white	white	ADJ
easat-249	9	37	man	man	NOUN
easat-249	9	38	with	with	ADP
easat-249	9	39	past	past	ADJ
easat-249	9	40	medical	medical	ADJ
easat-249	9	41	history	history	NOUN
easat-249	9	42	of	of	ADP
easat-249	9	43	aatd	aatd	NOUN
easat-249	9	44	associated	associate	VERB
easat-249	9	45	with	with	ADP
easat-249	9	46	emphysema	emphysema	NOUN
easat-249	9	47	but	but	CCONJ
easat-249	9	48	no	no	DET
easat-249	9	49	other	other	ADJ
easat-249	9	50	comorbidities	comorbiditie	NOUN
easat-249	9	51	present	present	ADJ
easat-249	9	52	to	to	ADP
easat-249	9	53	the	the	DET
easat-249	9	54	office	office	NOUN
easat-249	9	55	with	with	ADP
easat-249	9	56	lower	low	ADJ
easat-249	9	57	extremity	extremity	NOUN
easat-249	9	58	swelling	swell	VERB
easat-249	9	59	for	for	ADP
easat-249	9	60	1	1	NUM
easat-249	9	61	month	month	NOUN
easat-249	9	62	.	.	PUNCT
easat-249	10	1	on	on	ADP
easat-249	10	2	physical	physical	ADJ
easat-249	10	3	exam	exam	NOUN
easat-249	10	4	he	he	PRON
easat-249	10	5	had	have	VERB
easat-249	10	6	2	2	NUM
easat-249	10	7	+	+	NOUN
easat-249	10	8	pitting	pit	VERB
easat-249	10	9	edema	edema	NOUN
easat-249	10	10	in	in	ADP
easat-249	10	11	lower	low	ADJ
easat-249	10	12	extremities	extremity	NOUN
easat-249	10	13	.	.	PUNCT
easat-249	11	1	lung	lung	NOUN
easat-249	11	2	examination	examination	NOUN
easat-249	11	3	had	have	VERB
easat-249	11	4	fine	fine	ADJ
easat-249	11	5	rales	rales	ADJ
easat-249	11	6	bilateral	bilateral	ADJ
easat-249	11	7	bases	basis	NOUN
easat-249	11	8	.	.	PUNCT
easat-249	12	1	patient	patient	NOUN
easat-249	12	2	was	be	AUX
easat-249	12	3	not	not	PART
easat-249	12	4	short	short	ADJ
easat-249	12	5	of	of	ADP
easat-249	12	6	breath	breath	NOUN
easat-249	12	7	it	it	PRON
easat-249	12	8	looks	look	VERB
easat-249	12	9	comfortable	comfortable	ADJ
easat-249	12	10	saturation	saturation	NOUN
easat-249	12	11	was	be	AUX
easat-249	12	12	99	99	NUM
easat-249	12	13	%	%	NOUN
easat-249	12	14	room	room	NOUN
easat-249	12	15	air	air	NOUN
easat-249	12	16	.	.	PUNCT
easat-249	13	1	vitals	vital	NOUN
easat-249	13	2	were	be	AUX
easat-249	13	3	stable	stable	ADJ
easat-249	13	4	.	.	PUNCT
easat-249	14	1	considering	consider	VERB
easat-249	14	2	lower	low	ADJ
easat-249	14	3	extremity	extremity	NOUN
easat-249	14	4	edema	edema	NOUN
easat-249	14	5	and	and	CCONJ
easat-249	14	6	history	history	NOUN
easat-249	14	7	of	of	ADP
easat-249	14	8	aatd	aatd	PROPN
easat-249	14	9	med	me	VERB
easat-249	14	10	me	i	PRON
easat-249	14	11	to	to	PART
easat-249	14	12	think	think	VERB
easat-249	14	13	to	to	PART
easat-249	14	14	check	check	VERB
easat-249	14	15	his	his	PRON
easat-249	14	16	liver	liver	NOUN
easat-249	14	17	functions	function	NOUN
easat-249	14	18	he	he	PRON
easat-249	14	19	could	could	AUX
easat-249	14	20	have	have	VERB
easat-249	14	21	hypoalbuminemia	hypoalbuminemia	NOUN
easat-249	14	22	and	and	CCONJ
easat-249	14	23	cirrhosis	cirrhosis	NOUN
easat-249	14	24	.	.	PUNCT
easat-249	15	1	ultrasound	ultrasound	NOUN
easat-249	15	2	of	of	ADP
easat-249	15	3	the	the	DET
easat-249	15	4	liver	liver	NOUN
easat-249	15	5	demonstrated	demonstrate	VERB
easat-249	15	6	patient	patient	ADJ
easat-249	15	7	having	have	VERB
easat-249	15	8	cirrhosis	cirrhosis	NOUN
easat-249	15	9	and	and	CCONJ
easat-249	15	10	blood	blood	NOUN
easat-249	15	11	test	test	NOUN
easat-249	15	12	revealed	reveal	VERB
easat-249	15	13	hypoalbuminemia	hypoalbuminemia	ADV
easat-249	15	14	that	that	PRON
easat-249	15	15	prompted	prompt	VERB
easat-249	15	16	he	he	PRON
easat-249	15	17	should	should	AUX
easat-249	15	18	be	be	AUX
easat-249	15	19	checked	check	VERB
easat-249	15	20	for	for	ADP
easat-249	15	21	d	d	NOUN
easat-249	15	22	-	-	PUNCT
easat-249	15	23	dimers	dimer	NOUN
easat-249	15	24	as	as	SCONJ
easat-249	15	25	probability	probability	NOUN
easat-249	15	26	was	be	AUX
easat-249	15	27	high	high	ADJ
easat-249	15	28	.	.	PUNCT
easat-249	16	1	d	d	X
easat-249	16	2	-	-	PUNCT
easat-249	16	3	dimers	dimer	NOUN
easat-249	16	4	were	be	AUX
easat-249	16	5	elevated	elevate	VERB
easat-249	16	6	subsequently	subsequently	ADV
easat-249	16	7	went	go	VERB
easat-249	16	8	for	for	ADP
easat-249	16	9	ultrasound	ultrasound	NOUN
easat-249	16	10	of	of	ADP
easat-249	16	11	lower	low	ADJ
easat-249	16	12	extremity	extremity	NOUN
easat-249	16	13	and	and	CCONJ
easat-249	16	14	dvt	dvt	PROPN
easat-249	16	15	was	be	AUX
easat-249	16	16	found	find	VERB
easat-249	16	17	and	and	CCONJ
easat-249	16	18	subsequently	subsequently	ADV
easat-249	16	19	ct	ct	PROPN
easat-249	16	20	scan	scan	PROPN
easat-249	16	21	showed	show	VERB
easat-249	16	22	pulmonary	pulmonary	ADJ
easat-249	16	23	embolism	embolism	NOUN
easat-249	16	24	,	,	PUNCT
easat-249	16	25	further	further	ADJ
easat-249	16	26	workup	workup	PROPN
easat-249	16	27	showed	show	VERB
easat-249	16	28	decreased	decrease	VERB
easat-249	16	29	protein	protein	NOUN
easat-249	16	30	c	c	NOUN
easat-249	16	31	and	and	CCONJ
easat-249	16	32	s	s	PROPN
easat-249	16	33	.	.	PUNCT
easat-249	17	1	that	that	SCONJ
easat-249	17	2	typically	typically	ADV
easat-249	17	3	due	due	ADJ
easat-249	17	4	to	to	ADP
easat-249	17	5	decreased	decrease	VERB
easat-249	17	6	synthetic	synthetic	ADJ
easat-249	17	7	function	function	NOUN
easat-249	17	8	of	of	ADP
easat-249	17	9	the	the	DET
easat-249	17	10	liver	liver	NOUN
easat-249	17	11	cirrhosis	cirrhosis	NOUN
easat-249	17	12	due	due	ADJ
easat-249	17	13	to	to	ADP
easat-249	17	14	aatd	aatd	PROPN
easat-249	17	15	.	.	PUNCT
easat-249	18	1	patient	patient	PROPN
easat-249	18	2	was	be	AUX
easat-249	18	3	admitted	admit	VERB
easat-249	18	4	to	to	ADP
easat-249	18	5	the	the	DET
easat-249	18	6	hospital	hospital	NOUN
easat-249	18	7	started	start	VERB
easat-249	18	8	on	on	ADP
easat-249	18	9	heparin	heparin	NOUN
easat-249	18	10	and	and	CCONJ
easat-249	18	11	got	get	AUX
easat-249	18	12	discharged	discharge	VERB
easat-249	18	13	within	within	ADP
easat-249	18	14	24	24	NUM
easat-249	18	15	hours	hour	NOUN
easat-249	18	16	to	to	ADP
easat-249	18	17	home	home	NOUN
easat-249	18	18	with	with	ADP
easat-249	18	19	newer	new	ADJ
easat-249	18	20	oral	oral	ADJ
easat-249	18	21	anticoagulant	anticoagulant	NOUN
easat-249	18	22	eliquis	eliquis	NOUN
easat-249	18	23	.	.	PUNCT
easat-249	19	1	patient	patient	PROPN
easat-249	19	2	's	's	PART
easat-249	19	3	other	other	ADJ
easat-249	19	4	anticoagulation	anticoagulation	NOUN
easat-249	19	5	profile	profile	NOUN
easat-249	19	6	anti	anti	ADJ
easat-249	19	7	-	-	ADJ
easat-249	19	8	thrombin	thrombin	ADJ
easat-249	19	9	iii	iii	NOUN
easat-249	19	10	of	of	ADP
easat-249	19	11	33	33	NUM
easat-249	19	12	μ	μ	NUM
easat-249	19	13	/	/	SYM
easat-249	19	14	dl	dl	PROPN
easat-249	19	15	(	(	PUNCT
easat-249	19	16	normal	normal	ADJ
easat-249	19	17	85	85	NUM
easat-249	19	18	-	-	SYM
easat-249	19	19	130	130	NUM
easat-249	19	20	μ	μ	NUM
easat-249	19	21	/	/	SYM
easat-249	19	22	dl	dl	PROPN
easat-249	19	23	)	)	PUNCT
easat-249	19	24	with	with	ADP
easat-249	19	25	negative	negative	ADJ
easat-249	19	26	factor	factor	NOUN
easat-249	19	27	v	v	NOUN
easat-249	19	28	mutation	mutation	NOUN
easat-249	19	29	,	,	PUNCT
easat-249	19	30	lupus	lupus	NOUN
easat-249	19	31	anticoagulant	anticoagulant	VERB
easat-249	19	32	negative	negative	ADJ
easat-249	19	33	.	.	PUNCT
easat-249	20	1	2	2	X
easat-249	20	2	.	.	X
easat-249	20	3	workup	workup	ADJ
easat-249	20	4	laboratory	laboratory	NOUN
easat-249	20	5	diagnostics	diagnostic	NOUN
easat-249	20	6	revealed	reveal	VERB
easat-249	20	7	white	white	ADJ
easat-249	20	8	cell	cell	NOUN
easat-249	20	9	count	count	NOUN
easat-249	20	10	of	of	ADP
easat-249	20	11	71000	71000	NUM
easat-249	20	12	without	without	ADP
easat-249	20	13	any	any	DET
easat-249	20	14	neutrophilia	neutrophilia	NOUN
easat-249	20	15	.	.	PUNCT
easat-249	21	1	d	d	X
easat-249	21	2	-	-	PUNCT
easat-249	21	3	dimers	dimer	NOUN
easat-249	21	4	were	be	AUX
easat-249	21	5	elevated	elevate	VERB
easat-249	21	6	2.0	2.0	NUM
easat-249	21	7	8	8	NUM
easat-249	21	8	.	.	PUNCT
easat-249	22	1	sodium	sodium	NOUN
easat-249	22	2	latest	late	ADJ
easat-249	22	3	ref	ref	NOUN
easat-249	22	4	range	range	NOUN
easat-249	22	5	:	:	PUNCT
easat-249	22	6	136	136	NUM
easat-249	22	7	145	145	NUM
easat-249	22	8	meq	meq	NUM
easat-249	22	9	/	/	SYM
easat-249	22	10	l	l	NOUN
easat-249	22	11	139	139	NUM
easat-249	22	12	potassium	potassium	NOUN
easat-249	22	13	latest	late	ADJ
easat-249	22	14	ref	ref	NOUN
easat-249	22	15	range	range	NOUN
easat-249	22	16	:	:	PUNCT
easat-249	22	17	3.5	3.5	NUM
easat-249	22	18	5.1	5.1	NUM
easat-249	22	19	meq	meq	NUM
easat-249	22	20	/	/	SYM
easat-249	22	21	l	l	NOUN
easat-249	22	22	4.1	4.1	NUM
easat-249	22	23	chloride	chloride	NOUN
easat-249	22	24	latest	late	ADJ
easat-249	22	25	ref	ref	NOUN
easat-249	22	26	range	range	NOUN
easat-249	22	27	:	:	PUNCT
easat-249	22	28	98	98	NUM
easat-249	22	29	107	107	NUM
easat-249	22	30	meq	meq	NUM
easat-249	22	31	/	/	SYM
easat-249	22	32	l	l	NOUN
easat-249	22	33	104	104	NUM
easat-249	22	34	co2	co2	NOUN
easat-249	22	35	latest	late	ADJ
easat-249	22	36	ref	ref	NOUN
easat-249	22	37	range	range	NOUN
easat-249	22	38	:	:	PUNCT
easat-249	22	39	21.0	21.0	NUM
easat-249	22	40	31.0	31.0	NUM
easat-249	22	41	meq	meq	NUM
easat-249	22	42	/	/	SYM
easat-249	22	43	l	l	NOUN
easat-249	22	44	29.7	29.7	NUM
easat-249	22	45	anion	anion	NOUN
easat-249	22	46	gap	gap	NOUN
easat-249	22	47	latest	late	ADJ
easat-249	22	48	ref	ref	NOUN
easat-249	22	49	range	range	NOUN
easat-249	22	50	:	:	PUNCT
easat-249	22	51	7	7	NUM
easat-249	22	52	17	17	NUM
easat-249	22	53	meq	meq	NUM
easat-249	22	54	/	/	SYM
easat-249	22	55	l	l	NOUN
easat-249	22	56	5	5	NUM
easat-249	22	57	(	(	PUNCT
easat-249	22	58	l	l	NOUN
easat-249	22	59	)	)	PUNCT
easat-249	22	60	bun	bun	PROPN
easat-249	22	61	latest	late	ADJ
easat-249	22	62	ref	ref	NOUN
easat-249	22	63	range	range	NOUN
easat-249	22	64	:	:	PUNCT
easat-249	22	65	7	7	NUM
easat-249	22	66	25	25	NUM
easat-249	22	67	mg	mg	PROPN
easat-249	22	68	/	/	SYM
easat-249	22	69	dl	dl	PROPN
easat-249	22	70	12	12	NUM
easat-249	22	71	creatinine	creatinine	NOUN
easat-249	22	72	latest	late	ADJ
easat-249	22	73	ref	ref	NOUN
easat-249	22	74	range	range	NOUN
easat-249	22	75	:	:	PUNCT
easat-249	22	76	0.60	0.60	NUM
easat-249	22	77	1.30	1.30	NUM
easat-249	22	78	mg	mg	PROPN
easat-249	22	79	/	/	SYM
easat-249	22	80	dl	dl	PROPN
easat-249	22	81	0.76	0.76	NUM
easat-249	22	82	egfr	egfr	NOUN
easat-249	22	83	(	(	PUNCT
easat-249	22	84	mdrd	mdrd	PROPN
easat-249	22	85	)	)	PUNCT
easat-249	22	86	unknown	unknown	ADJ
easat-249	22	87	104.27	104.27	NUM
easat-249	22	88	glucose	glucose	NOUN
easat-249	22	89	latest	late	ADJ
easat-249	22	90	ref	ref	NOUN
easat-249	22	91	range	range	NOUN
easat-249	22	92	:	:	PUNCT
easat-249	22	93	70	70	NUM
easat-249	22	94	99	99	NUM
easat-249	22	95	mg	mg	NUM
easat-249	22	96	/	/	SYM
easat-249	22	97	dl	dl	PROPN
easat-249	22	98	78	78	NUM
easat-249	22	99	calcium	calcium	NOUN
easat-249	22	100	latest	late	ADJ
easat-249	22	101	ref	ref	NOUN
easat-249	22	102	range	range	NOUN
easat-249	22	103	:	:	PUNCT
easat-249	22	104	8.6	8.6	NUM
easat-249	22	105	10.3	10.3	NUM
easat-249	22	106	mg	mg	PROPN
easat-249	22	107	/	/	SYM
easat-249	22	108	dl	dl	PROPN
easat-249	22	109	8.8	8.8	NUM
easat-249	22	110	alk	alk	NOUN
easat-249	22	111	phos	phos	PROPN
easat-249	22	112	latest	late	ADJ
easat-249	22	113	ref	ref	NOUN
easat-249	22	114	range	range	NOUN
easat-249	22	115	:	:	PUNCT
easat-249	22	116	34	34	NUM
easat-249	22	117	104	104	NUM
easat-249	22	118	iu	iu	PROPN
easat-249	22	119	/	/	SYM
easat-249	22	120	l	l	NOUN
easat-249	22	121	147	147	NUM
easat-249	22	122	(	(	PUNCT
easat-249	22	123	h	h	NOUN
easat-249	22	124	)	)	PUNCT
easat-249	22	125	albumin	albumin	ADJ
easat-249	22	126	latest	late	ADJ
easat-249	22	127	ref	ref	NOUN
easat-249	22	128	range	range	NOUN
easat-249	22	129	:	:	PUNCT
easat-249	22	130	3.5	3.5	NUM
easat-249	22	131	5.7	5.7	NUM
easat-249	22	132	g	g	NOUN
easat-249	22	133	/	/	SYM
easat-249	22	134	dl	dl	PROPN
easat-249	22	135	2.5	2.5	NUM
easat-249	22	136	(	(	PUNCT
easat-249	22	137	l	l	NOUN
easat-249	22	138	)	)	PUNCT
easat-249	22	139	total	total	ADJ
easat-249	22	140	protein	protein	NOUN
easat-249	22	141	latest	late	ADJ
easat-249	22	142	ref	ref	NOUN
easat-249	22	143	range	range	NOUN
easat-249	22	144	:	:	PUNCT
easat-249	22	145	6.4	6.4	NUM
easat-249	22	146	8.9	8.9	NUM
easat-249	22	147	g	g	NOUN
easat-249	22	148	/	/	SYM
easat-249	22	149	dl	dl	PROPN
easat-249	22	150	5.7	5.7	NUM
easat-249	22	151	(	(	PUNCT
easat-249	22	152	l	l	NOUN
easat-249	22	153	)	)	PUNCT
easat-249	22	154	ast	ast	NOUN
easat-249	23	1	latest	late	ADJ
easat-249	23	2	ref	ref	NOUN
easat-249	23	3	range	range	NOUN
easat-249	23	4	:	:	PUNCT
easat-249	23	5	13	13	NUM
easat-249	23	6	39	39	NUM
easat-249	23	7	iu	iu	PROPN
easat-249	23	8	/	/	SYM
easat-249	23	9	l	l	NOUN
easat-249	23	10	49	49	NUM
easat-249	23	11	(	(	PUNCT
easat-249	23	12	h	h	NOUN
easat-249	23	13	)	)	PUNCT
easat-249	23	14	alt	alt	VERB
easat-249	23	15	latest	late	ADJ
easat-249	23	16	ref	ref	NOUN
easat-249	23	17	range	range	NOUN
easat-249	23	18	:	:	PUNCT
easat-249	23	19	7	7	NUM
easat-249	23	20	52	52	NUM
easat-249	23	21	iu	iu	NOUN
easat-249	23	22	/	/	SYM
easat-249	23	23	l	l	NOUN
easat-249	23	24	39	39	NUM
easat-249	23	25	total	total	ADJ
easat-249	23	26	bilirubin	bilirubin	NOUN
easat-249	23	27	latest	late	ADJ
easat-249	23	28	ref	ref	NOUN
easat-249	23	29	range	range	NOUN
easat-249	23	30	:	:	PUNCT
easat-249	23	31	0.3	0.3	NUM
easat-249	23	32	1.0	1.0	NUM
easat-249	23	33	mg	mg	PROPN
easat-249	23	34	/	/	SYM
easat-249	23	35	dl	dl	PROPN
easat-249	23	36	4.3	4.3	NUM
easat-249	23	37	(	(	PUNCT
easat-249	23	38	h	h	NOUN
easat-249	23	39	)	)	PUNCT
easat-249	23	40	protein	protein	NOUN
easat-249	23	41	s	s	PART
easat-249	23	42	activity	activity	NOUN
easat-249	23	43	65	65	NUM
easat-249	23	44	%	%	NOUN
easat-249	23	45	normal	normal	ADJ
easat-249	23	46	ranges	range	VERB
easat-249	23	47	77	77	NUM
easat-249	23	48	to	to	PART
easat-249	23	49	143	143	NUM
easat-249	23	50	%	%	NOUN
easat-249	23	51	protein	protein	NOUN
easat-249	23	52	c	c	NOUN
easat-249	23	53	activity	activity	NOUN
easat-249	23	54	42	42	NUM
easat-249	23	55	%	%	NOUN
easat-249	23	56	with	with	ADP
easat-249	23	57	range	range	NOUN
easat-249	23	58	of	of	ADP
easat-249	23	59	70	70	NUM
easat-249	23	60	to	to	PART
easat-249	23	61	130	130	NUM
easat-249	23	62	%	%	NOUN
easat-249	23	63	figure	figure	NOUN
easat-249	23	64	1	1	NUM
easat-249	23	65	.	.	PUNCT
easat-249	24	1	ct	ct	PROPN
easat-249	24	2	scan	scan	NOUN
easat-249	24	3	showing	show	VERB
easat-249	24	4	bilateral	bilateral	ADJ
easat-249	24	5	pulmonary	pulmonary	ADJ
easat-249	24	6	embolism	embolism	NOUN
easat-249	24	7	with	with	ADP
easat-249	24	8	mild	mild	ADJ
easat-249	24	9	right	right	ADJ
easat-249	24	10	heart	heart	NOUN
easat-249	24	11	strain	strain	NOUN
easat-249	24	12	.	.	PUNCT
easat-249	25	1	233	233	NUM
easat-249	25	2	edelweiss	edelweiss	PROPN
easat-249	25	3	applied	apply	VERB
easat-249	25	4	science	science	NOUN
easat-249	25	5	and	and	CCONJ
easat-249	25	6	technology	technology	NOUN
easat-249	25	7	issn	issn	PROPN
easat-249	25	8	:	:	PUNCT
easat-249	25	9	2576	2576	NUM
easat-249	25	10	-	-	SYM
easat-249	25	11	8484	8484	NUM
easat-249	25	12	vol	vol	NOUN
easat-249	25	13	.	.	PROPN
easat-249	26	1	2	2	NUM
easat-249	26	2	,	,	PUNCT
easat-249	26	3	no	no	INTJ
easat-249	26	4	.	.	NOUN
easat-249	26	5	1	1	NUM
easat-249	26	6	:	:	SYM
easat-249	26	7	232	232	NUM
easat-249	26	8	-	-	SYM
easat-249	26	9	233	233	NUM
easat-249	26	10	,	,	PUNCT
easat-249	26	11	2018	2018	NUM
easat-249	26	12	doi	doi	NOUN
easat-249	26	13	:	:	PUNCT
easat-249	26	14	10.33805/2576	10.33805/2576	NUM
easat-249	26	15	-	-	SYM
easat-249	26	16	8484.144	8484.144	NUM
easat-249	26	17	©	©	PROPN
easat-249	26	18	2018	2018	NUM
easat-249	26	19	by	by	ADP
easat-249	26	20	the	the	DET
easat-249	26	21	author	author	NOUN
easat-249	26	22	lower	low	ADJ
easat-249	26	23	extremity	extremity	NOUN
easat-249	26	24	doppler	doppler	NOUN
easat-249	26	25	:	:	PUNCT
easat-249	26	26	evidence	evidence	NOUN
easat-249	26	27	of	of	ADP
easat-249	26	28	dvt	dvt	PROPN
easat-249	26	29	involving	involve	VERB
easat-249	26	30	the	the	DET
easat-249	26	31	left	left	ADJ
easat-249	26	32	calf	calf	NOUN
easat-249	26	33	muscle	muscle	NOUN
easat-249	26	34	branches	branch	NOUN
easat-249	26	35	/	/	SYM
easat-249	26	36	gastrocnemius	gastrocnemius	NOUN
easat-249	26	37	.	.	PUNCT
easat-249	27	1	no	no	DET
easat-249	27	2	evidence	evidence	NOUN
easat-249	27	3	of	of	ADP
easat-249	27	4	other	other	ADJ
easat-249	27	5	dvts	dvts	NOUN
easat-249	27	6	or	or	CCONJ
easat-249	27	7	superficial	superficial	ADJ
easat-249	27	8	phlebitis	phlebitis	NOUN
easat-249	27	9	involving	involve	VERB
easat-249	27	10	bilateral	bilateral	ADJ
easat-249	27	11	lower	low	ADJ
easat-249	27	12	extremity	extremity	NOUN
easat-249	27	13	.	.	PUNCT
easat-249	28	1	ct	ct	PROPN
easat-249	28	2	scan	scan	PROPN
easat-249	28	3	chest	chest	PROPN
easat-249	28	4	stat	stat	PROPN
easat-249	28	5	done	do	VERB
easat-249	28	6	showed	show	VERB
easat-249	28	7	:	:	PUNCT
easat-249	28	8	acute	acute	ADJ
easat-249	28	9	pulmonary	pulmonary	ADJ
easat-249	28	10	emboli	emboli	NOUN
easat-249	28	11	in	in	ADP
easat-249	28	12	both	both	CCONJ
easat-249	28	13	upper	upper	ADJ
easat-249	28	14	and	and	CCONJ
easat-249	28	15	lower	low	ADJ
easat-249	28	16	lobes	lobe	NOUN
easat-249	28	17	pulmonary	pulmonary	ADJ
easat-249	28	18	arterial	arterial	ADJ
easat-249	28	19	branches	branch	NOUN
easat-249	28	20	with	with	ADP
easat-249	28	21	mild	mild	ADJ
easat-249	28	22	right	right	ADJ
easat-249	28	23	heart	heart	NOUN
easat-249	28	24	strain	strain	NOUN
easat-249	28	25	.	.	PUNCT
easat-249	29	1	3	3	X
easat-249	29	2	.	.	X
easat-249	29	3	discussion	discussion	NOUN
easat-249	29	4	although	although	SCONJ
easat-249	29	5	alpha-1	alpha-1	NUM
easat-249	29	6	antitrypsin	antitrypsin	NOUN
easat-249	29	7	deficiency	deficiency	NOUN
easat-249	29	8	(	(	PUNCT
easat-249	29	9	aatd	aatd	NOUN
easat-249	29	10	)	)	PUNCT
easat-249	29	11	is	be	AUX
easat-249	29	12	generally	generally	ADV
easat-249	29	13	considered	consider	VERB
easat-249	29	14	to	to	PART
easat-249	29	15	be	be	AUX
easat-249	29	16	rare	rare	ADJ
easat-249	29	17	,	,	PUNCT
easat-249	29	18	estimates	estimate	VERB
easat-249	29	19	that	that	SCONJ
easat-249	29	20	80,000	80,000	NUM
easat-249	29	21	to	to	PART
easat-249	29	22	100,000	100,000	NUM
easat-249	29	23	individuals	individual	NOUN
easat-249	29	24	in	in	ADP
easat-249	29	25	the	the	DET
easat-249	29	26	united	united	PROPN
easat-249	29	27	states	states	PROPN
easat-249	29	28	have	have	VERB
easat-249	29	29	severe	severe	ADJ
easat-249	29	30	deficiency	deficiency	NOUN
easat-249	29	31	of	of	ADP
easat-249	29	32	aat	aat	PROPN
easat-249	29	33	suggest	suggest	VERB
easat-249	29	34	that	that	SCONJ
easat-249	29	35	the	the	DET
easat-249	29	36	disease	disease	NOUN
easat-249	29	37	is	be	AUX
easat-249	29	38	under	under	ADP
easat-249	29	39	recognized	recognize	VERB
easat-249	29	40	[	[	X
easat-249	29	41	1	1	NUM
easat-249	29	42	,	,	PUNCT
easat-249	29	43	2	2	NUM
easat-249	29	44	]	]	PUNCT
easat-249	29	45	.	.	PUNCT
easat-249	30	1	the	the	DET
easat-249	30	2	prevalence	prevalence	NOUN
easat-249	30	3	of	of	ADP
easat-249	30	4	aat	aat	PROPN
easat-249	30	5	varies	vary	VERB
easat-249	30	6	considerably	considerably	ADV
easat-249	30	7	from	from	ADP
easat-249	30	8	one	one	NUM
easat-249	30	9	country	country	NOUN
easat-249	30	10	to	to	ADP
easat-249	30	11	another	another	PRON
easat-249	30	12	[	[	X
easat-249	30	13	3	3	NUM
easat-249	30	14	]	]	PUNCT
easat-249	30	15	;	;	PUNCT
easat-249	30	16	however	however	ADV
easat-249	30	17	,	,	PUNCT
easat-249	30	18	it	it	PRON
easat-249	30	19	is	be	AUX
easat-249	30	20	estimated	estimate	VERB
easat-249	30	21	that	that	SCONJ
easat-249	30	22	more	more	ADJ
easat-249	30	23	than	than	ADP
easat-249	30	24	3	3	NUM
easat-249	30	25	million	million	NUM
easat-249	30	26	people	people	NOUN
easat-249	30	27	worldwide	worldwide	ADV
easat-249	30	28	have	have	VERB
easat-249	30	29	allele	allele	NOUN
easat-249	30	30	combinations	combination	NOUN
easat-249	30	31	associated	associate	VERB
easat-249	30	32	with	with	ADP
easat-249	30	33	severe	severe	ADJ
easat-249	30	34	deficiency	deficiency	NOUN
easat-249	30	35	of	of	ADP
easat-249	30	36	aat	aat	NOUN
easat-249	31	1	[	[	X
easat-249	31	2	4,5	4,5	NUM
easat-249	31	3	]	]	PUNCT
easat-249	31	4	.	.	PUNCT
easat-249	32	1	aat	aat	PROPN
easat-249	32	2	is	be	AUX
easat-249	32	3	a	a	DET
easat-249	32	4	protease	protease	NOUN
easat-249	32	5	inhibitor	inhibitor	NOUN
easat-249	32	6	(	(	PUNCT
easat-249	32	7	pi	pi	NOUN
easat-249	32	8	)	)	PUNCT
easat-249	32	9	of	of	ADP
easat-249	32	10	the	the	DET
easat-249	32	11	proteolytic	proteolytic	ADJ
easat-249	32	12	enzyme	enzyme	NOUN
easat-249	32	13	elastase	elastase	NOUN
easat-249	32	14	and	and	CCONJ
easat-249	32	15	also	also	ADV
easat-249	32	16	of	of	ADP
easat-249	32	17	the	the	DET
easat-249	32	18	proteases	protease	NOUN
easat-249	32	19	trypsin	trypsin	NOUN
easat-249	32	20	,	,	PUNCT
easat-249	32	21	chymotrypsin	chymotrypsin	NOUN
easat-249	32	22	,	,	PUNCT
easat-249	32	23	and	and	CCONJ
easat-249	32	24	thrombin	thrombin	NOUN
easat-249	32	25	.	.	PUNCT
easat-249	33	1	it	it	PRON
easat-249	33	2	is	be	AUX
easat-249	33	3	part	part	NOUN
easat-249	33	4	of	of	ADP
easat-249	33	5	a	a	DET
easat-249	33	6	larger	large	ADJ
easat-249	33	7	family	family	NOUN
easat-249	33	8	of	of	ADP
easat-249	33	9	structurally	structurally	ADV
easat-249	33	10	unique	unique	ADJ
easat-249	33	11	serine	serine	NOUN
easat-249	33	12	protease	protease	NOUN
easat-249	33	13	inhibitors	inhibitor	NOUN
easat-249	33	14	,	,	PUNCT
easat-249	33	15	referred	refer	VERB
easat-249	33	16	to	to	ADP
easat-249	33	17	as	as	ADP
easat-249	33	18	serpins	serpin	NOUN
easat-249	33	19	,	,	PUNCT
easat-249	33	20	which	which	PRON
easat-249	33	21	have	have	AUX
easat-249	33	22	also	also	ADV
easat-249	33	23	been	be	AUX
easat-249	33	24	implicated	implicate	VERB
easat-249	33	25	in	in	ADP
easat-249	33	26	the	the	DET
easat-249	33	27	pathogenesis	pathogenesis	NOUN
easat-249	33	28	of	of	ADP
easat-249	33	29	neurodegenerative	neurodegenerative	ADJ
easat-249	33	30	diseases	disease	NOUN
easat-249	33	31	,	,	PUNCT
easat-249	33	32	angioedema	angioedema	VERB
easat-249	33	33	,	,	PUNCT
easat-249	33	34	and	and	CCONJ
easat-249	33	35	coagulation	coagulation	NOUN
easat-249	33	36	abnormalities	abnormality	NOUN
easat-249	33	37	,	,	PUNCT
easat-249	33	38	collectively	collectively	ADV
easat-249	33	39	called	call	VERB
easat-249	33	40	"	"	PUNCT
easat-249	33	41	serpinopathies	serpinopathie	NOUN
easat-249	33	42	"	"	PUNCT
easat-249	33	43	[	[	X
easat-249	33	44	9,10	9,10	NUM
easat-249	33	45	]	]	X
easat-249	33	46	.	.	PUNCT
easat-249	34	1	emphysema	emphysema	ADJ
easat-249	34	2	in	in	ADP
easat-249	34	3	aat	aat	ADJ
easat-249	34	4	deficiency	deficiency	NOUN
easat-249	34	5	(	(	PUNCT
easat-249	34	6	aatd	aatd	NOUN
easat-249	34	7	)	)	PUNCT
easat-249	34	8	is	be	AUX
easat-249	34	9	thought	think	VERB
easat-249	34	10	to	to	PART
easat-249	34	11	result	result	VERB
easat-249	34	12	from	from	ADP
easat-249	34	13	an	an	DET
easat-249	34	14	imbalance	imbalance	NOUN
easat-249	34	15	between	between	ADP
easat-249	34	16	neutrophil	neutrophil	ADJ
easat-249	34	17	elastase	elastase	NOUN
easat-249	34	18	in	in	ADP
easat-249	34	19	the	the	DET
easat-249	34	20	lung	lung	NOUN
easat-249	34	21	,	,	PUNCT
easat-249	34	22	which	which	PRON
easat-249	34	23	destroys	destroy	VERB
easat-249	34	24	elastin	elastin	NOUN
easat-249	34	25	,	,	PUNCT
easat-249	34	26	and	and	CCONJ
easat-249	34	27	the	the	DET
easat-249	34	28	elastase	elastase	ADJ
easat-249	34	29	inhibitor	inhibitor	NOUN
easat-249	34	30	aat	aat	NOUN
easat-249	34	31	,	,	PUNCT
easat-249	34	32	which	which	PRON
easat-249	34	33	protects	protect	VERB
easat-249	34	34	against	against	ADP
easat-249	34	35	proteolytic	proteolytic	ADJ
easat-249	34	36	degradation	degradation	NOUN
easat-249	34	37	of	of	ADP
easat-249	34	38	elastin	elastin	NOUN
easat-249	34	39	.	.	PUNCT
easat-249	35	1	this	this	DET
easat-249	35	2	mechanism	mechanism	NOUN
easat-249	35	3	is	be	AUX
easat-249	35	4	called	call	VERB
easat-249	35	5	a	a	DET
easat-249	35	6	"	"	PUNCT
easat-249	35	7	toxic	toxic	ADJ
easat-249	35	8	loss	loss	NOUN
easat-249	35	9	of	of	ADP
easat-249	35	10	function	function	NOUN
easat-249	35	11	.	.	PUNCT
easat-249	35	12	"	"	PUNCT
easat-249	36	1	specifically	specifically	ADV
easat-249	36	2	,	,	PUNCT
easat-249	36	3	cigarette	cigarette	NOUN
easat-249	36	4	smoking	smoking	NOUN
easat-249	36	5	and	and	CCONJ
easat-249	36	6	infection	infection	NOUN
easat-249	36	7	increase	increase	VERB
easat-249	36	8	the	the	DET
easat-249	36	9	elastase	elastase	ADJ
easat-249	36	10	burden	burden	NOUN
easat-249	36	11	in	in	ADP
easat-249	36	12	the	the	DET
easat-249	36	13	lung	lung	NOUN
easat-249	36	14	,	,	PUNCT
easat-249	36	15	thus	thus	ADV
easat-249	36	16	increasing	increase	VERB
easat-249	36	17	lung	lung	NOUN
easat-249	36	18	degradation	degradation	NOUN
easat-249	36	19	[	[	X
easat-249	36	20	10	10	NUM
easat-249	36	21	]	]	PUNCT
easat-249	36	22	.	.	PUNCT
easat-249	37	1	in	in	ADP
easat-249	37	2	addition	addition	NOUN
easat-249	37	3	,	,	PUNCT
easat-249	37	4	the	the	DET
easat-249	37	5	polymers	polymer	NOUN
easat-249	37	6	of	of	ADP
easat-249	37	7	"	"	PUNCT
easat-249	37	8	z	z	ADJ
easat-249	37	9	"	"	PUNCT
easat-249	37	10	antitrypsin	antitrypsin	NOUN
easat-249	37	11	are	be	AUX
easat-249	37	12	chemotactic	chemotactic	ADJ
easat-249	37	13	for	for	ADP
easat-249	37	14	neutrophils	neutrophil	NOUN
easat-249	37	15	,	,	PUNCT
easat-249	37	16	which	which	PRON
easat-249	37	17	may	may	AUX
easat-249	37	18	contribute	contribute	VERB
easat-249	37	19	to	to	ADP
easat-249	37	20	local	local	ADJ
easat-249	37	21	inflammation	inflammation	NOUN
easat-249	37	22	and	and	CCONJ
easat-249	37	23	tissue	tissue	NOUN
easat-249	37	24	destruction	destruction	NOUN
easat-249	37	25	in	in	ADP
easat-249	37	26	the	the	DET
easat-249	37	27	lung	lung	NOUN
easat-249	38	1	[	[	X
easat-249	38	2	11	11	NUM
easat-249	38	3	]	]	PUNCT
easat-249	38	4	.	.	PUNCT
easat-249	39	1	the	the	DET
easat-249	39	2	pathogenesis	pathogenesis	NOUN
easat-249	39	3	of	of	ADP
easat-249	39	4	the	the	DET
easat-249	39	5	liver	liver	NOUN
easat-249	39	6	disease	disease	NOUN
easat-249	39	7	is	be	AUX
easat-249	39	8	quite	quite	ADV
easat-249	39	9	different	different	ADJ
easat-249	39	10	and	and	CCONJ
easat-249	39	11	is	be	AUX
easat-249	39	12	called	call	VERB
easat-249	39	13	a	a	DET
easat-249	39	14	"	"	PUNCT
easat-249	39	15	toxic	toxic	ADJ
easat-249	39	16	gain	gain	NOUN
easat-249	39	17	of	of	ADP
easat-249	39	18	function	function	NOUN
easat-249	39	19	.	.	PUNCT
easat-249	39	20	"	"	PUNCT
easat-249	40	1	the	the	DET
easat-249	40	2	liver	liver	NOUN
easat-249	40	3	disease	disease	NOUN
easat-249	40	4	results	result	VERB
easat-249	40	5	from	from	ADP
easat-249	40	6	the	the	DET
easat-249	40	7	accumulation	accumulation	NOUN
easat-249	40	8	within	within	ADP
easat-249	40	9	the	the	DET
easat-249	40	10	hepatocyte	hepatocyte	NOUN
easat-249	40	11	of	of	ADP
easat-249	40	12	unsecreted	unsecreted	ADJ
easat-249	40	13	variant	variant	ADJ
easat-249	40	14	aat	aat	X
easat-249	40	15	protein	protein	NOUN
easat-249	40	16	.	.	PUNCT
easat-249	41	1	only	only	ADV
easat-249	41	2	those	those	DET
easat-249	41	3	genotypes	genotype	NOUN
easat-249	41	4	associated	associate	VERB
easat-249	41	5	with	with	ADP
easat-249	41	6	pathologic	pathologic	ADJ
easat-249	41	7	polymerization	polymerization	NOUN
easat-249	41	8	of	of	ADP
easat-249	41	9	aat	aat	NOUN
easat-249	41	10	within	within	ADP
easat-249	41	11	the	the	DET
easat-249	41	12	endoplasmic	endoplasmic	ADJ
easat-249	41	13	reticulum	reticulum	NOUN
easat-249	41	14	of	of	ADP
easat-249	41	15	hepatocytes	hepatocyte	NOUN
easat-249	41	16	(	(	PUNCT
easat-249	41	17	eg	eg	NOUN
easat-249	41	18	,	,	PUNCT
easat-249	41	19	pi*zz	pi*zz	NOUN
easat-249	41	20	type	type	NOUN
easat-249	41	21	aatd	aatd	PROPN
easat-249	41	22	)	)	PUNCT
easat-249	41	23	produce	produce	VERB
easat-249	41	24	disease	disease	NOUN
easat-249	41	25	[	[	X
easat-249	41	26	6	6	NUM
easat-249	41	27	-	-	SYM
easat-249	41	28	8	8	NUM
easat-249	41	29	]	]	PUNCT
easat-249	41	30	.	.	PUNCT
easat-249	42	1	most	most	ADJ
easat-249	42	2	patients	patient	NOUN
easat-249	42	3	with	with	ADP
easat-249	42	4	liver	liver	NOUN
easat-249	42	5	disease	disease	NOUN
easat-249	42	6	due	due	ADP
easat-249	42	7	to	to	ADP
easat-249	42	8	aatd	aatd	PROPN
easat-249	42	9	are	be	AUX
easat-249	42	10	homozygous	homozygous	ADJ
easat-249	42	11	for	for	ADP
easat-249	42	12	the	the	DET
easat-249	42	13	z	z	NOUN
easat-249	42	14	allele	allele	NOUN
easat-249	42	15	(	(	PUNCT
easat-249	42	16	ie	ie	X
easat-249	42	17	,	,	PUNCT
easat-249	42	18	pi*zz	pi*zz	NOUN
easat-249	42	19	)	)	PUNCT
easat-249	42	20	;	;	PUNCT
easat-249	42	21	liver	liver	NOUN
easat-249	42	22	disease	disease	NOUN
easat-249	42	23	does	do	AUX
easat-249	42	24	not	not	PART
easat-249	42	25	occur	occur	VERB
easat-249	42	26	in	in	ADP
easat-249	42	27	null	null	ADJ
easat-249	42	28	homozygotes	homozygote	NOUN
easat-249	42	29	who	who	PRON
easat-249	42	30	have	have	VERB
easat-249	42	31	severe	severe	ADJ
easat-249	42	32	deficiency	deficiency	NOUN
easat-249	42	33	of	of	ADP
easat-249	42	34	aat	aat	NOUN
easat-249	42	35	,	,	PUNCT
easat-249	42	36	but	but	CCONJ
easat-249	42	37	no	no	DET
easat-249	42	38	intra	intra	ADJ
easat-249	42	39	-	-	ADJ
easat-249	42	40	hepatocytic	hepatocytic	ADJ
easat-249	42	41	accumulation	accumulation	NOUN
easat-249	42	42	.	.	PUNCT
easat-249	43	1	patient	patient	NOUN
easat-249	43	2	did	do	AUX
easat-249	43	3	not	not	PART
easat-249	43	4	have	have	VERB
easat-249	43	5	any	any	DET
easat-249	43	6	other	other	ADJ
easat-249	43	7	significant	significant	ADJ
easat-249	43	8	meds	med	NOUN
easat-249	43	9	will	will	AUX
easat-249	43	10	history	history	NOUN
easat-249	43	11	that	that	PRON
easat-249	43	12	can	can	AUX
easat-249	43	13	lead	lead	VERB
easat-249	43	14	to	to	ADP
easat-249	43	15	hypercoagulability	hypercoagulability	NOUN
easat-249	43	16	except	except	SCONJ
easat-249	43	17	alpha	alpha	NOUN
easat-249	43	18	1	1	NUM
easat-249	43	19	antitrypsin	antitrypsin	NOUN
easat-249	43	20	deficiency	deficiency	NOUN
easat-249	43	21	leading	lead	VERB
easat-249	43	22	to	to	ADP
easat-249	43	23	liver	liver	NOUN
easat-249	43	24	cirrhosis	cirrhosis	NOUN
easat-249	43	25	causing	cause	VERB
easat-249	43	26	decreased	decrease	VERB
easat-249	43	27	protein	protein	NOUN
easat-249	43	28	c	c	NOUN
easat-249	43	29	and	and	CCONJ
easat-249	43	30	s	s	PRON
easat-249	43	31	activity	activity	NOUN
easat-249	43	32	leading	lead	VERB
easat-249	43	33	to	to	ADP
easat-249	43	34	dvt	dvt	PROPN
easat-249	43	35	and	and	CCONJ
easat-249	43	36	pulmonary	pulmonary	ADJ
easat-249	43	37	embolism	embolism	NOUN
easat-249	43	38	.	.	PUNCT
easat-249	44	1	we	we	PRON
easat-249	44	2	are	be	AUX
easat-249	44	3	publishing	publish	VERB
easat-249	44	4	the	the	DET
easat-249	44	5	unique	unique	ADJ
easat-249	44	6	aatd	aatd	NOUN
easat-249	44	7	with	with	ADP
easat-249	44	8	hypoalbuminemia	hypoalbuminemia	NOUN
easat-249	44	9	and	and	CCONJ
easat-249	44	10	decreased	decrease	VERB
easat-249	44	11	protein	protein	NOUN
easat-249	44	12	c	c	NOUN
easat-249	44	13	and	and	CCONJ
easat-249	44	14	s	s	PRON
easat-249	44	15	activity	activity	NOUN
easat-249	44	16	leading	lead	VERB
easat-249	44	17	to	to	ADP
easat-249	44	18	pulmonary	pulmonary	ADJ
easat-249	44	19	thrombosis	thrombosis	NOUN
easat-249	44	20	.	.	PUNCT
easat-249	45	1	this	this	DET
easat-249	45	2	case	case	NOUN
easat-249	45	3	is	be	AUX
easat-249	45	4	important	important	ADJ
easat-249	45	5	and	and	CCONJ
easat-249	45	6	sheds	shed	VERB
easat-249	45	7	light	light	NOUN
easat-249	45	8	in	in	ADP
easat-249	45	9	primary	primary	ADJ
easat-249	45	10	care	care	NOUN
easat-249	45	11	office	office	NOUN
easat-249	45	12	is	be	AUX
easat-249	45	13	the	the	DET
easat-249	45	14	patient	patient	NOUN
easat-249	45	15	with	with	ADP
easat-249	45	16	aatd	aatd	NOUN
easat-249	45	17	presents	present	NOUN
easat-249	45	18	for	for	ADP
easat-249	45	19	lower	low	ADJ
easat-249	45	20	extremity	extremity	NOUN
easat-249	45	21	swelling	swell	VERB
easat-249	45	22	should	should	AUX
easat-249	45	23	be	be	AUX
easat-249	45	24	worked	work	VERB
easat-249	45	25	up	up	ADP
easat-249	45	26	for	for	ADP
easat-249	45	27	hypoalbuminemia	hypoalbuminemia	NOUN
easat-249	45	28	leading	lead	VERB
easat-249	45	29	to	to	ADP
easat-249	45	30	protein	protein	NOUN
easat-249	45	31	c	c	NOUN
easat-249	45	32	and	and	CCONJ
easat-249	45	33	s	s	VERB
easat-249	45	34	deficiency	deficiency	NOUN
easat-249	45	35	and	and	CCONJ
easat-249	45	36	ultimately	ultimately	ADV
easat-249	45	37	leading	lead	VERB
easat-249	45	38	to	to	ADP
easat-249	45	39	pulmonary	pulmonary	ADJ
easat-249	45	40	embolism	embolism	NOUN
easat-249	45	41	.	.	PUNCT
easat-249	46	1	references	reference	NOUN
easat-249	46	2	[	[	X
easat-249	46	3	1	1	X
easat-249	46	4	]	]	PUNCT
easat-249	46	5	j.	j.	PROPN
easat-249	46	6	k.	k.	PROPN
easat-249	46	7	stoller	stoller	PROPN
easat-249	46	8	,	,	PUNCT
easat-249	46	9	r.	r.	PROPN
easat-249	46	10	a.	a.	PROPN
easat-249	46	11	sandhaus	sandhaus	PROPN
easat-249	46	12	,	,	PUNCT
easat-249	46	13	g.	g.	PROPN
easat-249	46	14	turino	turino	PROPN
easat-249	46	15	,	,	PUNCT
easat-249	46	16	r.	r.	PROPN
easat-249	46	17	dickson	dickson	PROPN
easat-249	46	18	,	,	PUNCT
easat-249	46	19	k.	k.	PROPN
easat-249	46	20	rodgers	rodgers	PROPN
easat-249	46	21	,	,	PUNCT
easat-249	46	22	and	and	CCONJ
easat-249	46	23	c.	c.	PROPN
easat-249	46	24	strange	strange	ADJ
easat-249	46	25	,	,	PUNCT
easat-249	46	26	"	"	PUNCT
easat-249	46	27	delay	delay	NOUN
easat-249	46	28	in	in	ADP
easat-249	46	29	diagnosis	diagnosis	NOUN
easat-249	46	30	of	of	ADP
easat-249	46	31	α1antitrypsin	α1antitrypsin	NOUN
easat-249	46	32	deficiency	deficiency	NOUN
easat-249	46	33	:	:	PUNCT
easat-249	46	34	a	a	DET
easat-249	46	35	continuing	continue	VERB
easat-249	46	36	problem	problem	NOUN
easat-249	46	37	,	,	PUNCT
easat-249	46	38	"	"	PUNCT
easat-249	46	39	chest	chest	NOUN
easat-249	46	40	,	,	PUNCT
easat-249	46	41	vol	vol	NOUN
easat-249	46	42	.	.	PROPN
easat-249	46	43	128	128	NUM
easat-249	46	44	,	,	PUNCT
easat-249	46	45	no	no	INTJ
easat-249	46	46	.	.	NOUN
easat-249	46	47	4	4	NUM
easat-249	46	48	,	,	PUNCT
easat-249	46	49	pp	pp	ADJ
easat-249	46	50	.	.	PUNCT
easat-249	46	51	1989	1989	NUM
easat-249	46	52	-	-	SYM
easat-249	46	53	1994	1994	NUM
easat-249	46	54	,	,	PUNCT
easat-249	46	55	2005	2005	NUM
easat-249	46	56	.	.	PUNCT
easat-249	47	1	https://doi.org/10.1378/chest.128.4.1989	https://doi.org/10.1378/chest.128.4.1989	PROPN
easat-249	47	2	[	[	X
easat-249	47	3	2	2	NUM
easat-249	47	4	]	]	PUNCT
easat-249	47	5	m.	m.	NOUN
easat-249	47	6	a.	a.	PROPN
easat-249	47	7	campos	campos	PROPN
easat-249	47	8	,	,	PUNCT
easat-249	47	9	a.	a.	NOUN
easat-249	47	10	wanner	wanner	NOUN
easat-249	47	11	,	,	PUNCT
easat-249	47	12	g.	g.	PROPN
easat-249	47	13	zhang	zhang	PROPN
easat-249	47	14	,	,	PUNCT
easat-249	47	15	and	and	CCONJ
easat-249	47	16	r.	r.	PROPN
easat-249	47	17	a.	a.	PROPN
easat-249	47	18	sandhaus	sandhaus	PROPN
easat-249	47	19	,	,	PUNCT
easat-249	47	20	"	"	PUNCT
easat-249	47	21	trends	trend	NOUN
easat-249	47	22	in	in	ADP
easat-249	47	23	the	the	DET
easat-249	47	24	diagnosis	diagnosis	NOUN
easat-249	47	25	of	of	ADP
easat-249	47	26	symptomatic	symptomatic	ADJ
easat-249	47	27	patients	patient	NOUN
easat-249	47	28	with	with	ADP
easat-249	47	29	α1antitrypsin	α1antitrypsin	NOUN
easat-249	47	30	deficiency	deficiency	NOUN
easat-249	47	31	between	between	ADP
easat-249	47	32	1968	1968	NUM
easat-249	47	33	and	and	CCONJ
easat-249	47	34	2003	2003	NUM
easat-249	47	35	,	,	PUNCT
easat-249	47	36	"	"	PUNCT
easat-249	47	37	chest	chest	NOUN
easat-249	47	38	,	,	PUNCT
easat-249	47	39	vol	vol	NOUN
easat-249	47	40	.	.	PROPN
easat-249	47	41	128	128	NUM
easat-249	47	42	,	,	PUNCT
easat-249	47	43	no	no	INTJ
easat-249	47	44	.	.	NOUN
easat-249	47	45	3	3	NUM
easat-249	47	46	,	,	PUNCT
easat-249	47	47	pp	pp	ADJ
easat-249	47	48	.	.	PUNCT
easat-249	48	1	1179	1179	NUM
easat-249	48	2	-	-	SYM
easat-249	48	3	1186	1186	NUM
easat-249	48	4	,	,	PUNCT
easat-249	48	5	2005	2005	NUM
easat-249	48	6	.	.	PUNCT
easat-249	49	1	https://doi.org/10.1378/chest.128.3.1179	https://doi.org/10.1378/chest.128.3.1179	VERB
easat-249	49	2	[	[	X
easat-249	49	3	3	3	NUM
easat-249	49	4	]	]	X
easat-249	49	5	i.	i.	PROPN
easat-249	49	6	blanco	blanco	PROPN
easat-249	49	7	,	,	PUNCT
easat-249	49	8	f.	f.	PROPN
easat-249	49	9	de	de	PROPN
easat-249	49	10	serres	serres	PROPN
easat-249	49	11	,	,	PUNCT
easat-249	49	12	e.	e.	PROPN
easat-249	49	13	fernandez	fernandez	PROPN
easat-249	49	14	-	-	PUNCT
easat-249	49	15	bustillo	bustillo	PROPN
easat-249	49	16	,	,	PUNCT
easat-249	49	17	b.	b.	PROPN
easat-249	49	18	lara	lara	PROPN
easat-249	49	19	,	,	PUNCT
easat-249	49	20	and	and	CCONJ
easat-249	49	21	m.	m.	NOUN
easat-249	49	22	miravitlles	miravitlle	NOUN
easat-249	49	23	,	,	PUNCT
easat-249	49	24	"	"	PUNCT
easat-249	49	25	estimated	estimated	ADJ
easat-249	49	26	numbers	number	NOUN
easat-249	49	27	and	and	CCONJ
easat-249	49	28	prevalence	prevalence	NOUN
easat-249	49	29	of	of	ADP
easat-249	49	30	pi	pi	NOUN
easat-249	49	31	*	*	SYM
easat-249	49	32	s	s	PROPN
easat-249	49	33	and	and	CCONJ
easat-249	49	34	pi	pi	NOUN
easat-249	49	35	*	*	PROPN
easat-249	49	36	z	z	NOUN
easat-249	49	37	alleles	allele	NOUN
easat-249	49	38	of	of	ADP
easat-249	49	39	α1	α1	ADJ
easat-249	49	40	-	-	PUNCT
easat-249	49	41	antitrypsin	antitrypsin	NOUN
easat-249	49	42	deficiency	deficiency	NOUN
easat-249	49	43	in	in	ADP
easat-249	49	44	european	european	ADJ
easat-249	49	45	countries	country	NOUN
easat-249	49	46	,	,	PUNCT
easat-249	49	47	"	"	PUNCT
easat-249	49	48	european	european	ADJ
easat-249	49	49	respiratory	respiratory	ADJ
easat-249	49	50	journal	journal	NOUN
easat-249	49	51	,	,	PUNCT
easat-249	49	52	vol	vol	NOUN
easat-249	49	53	.	.	PROPN
easat-249	49	54	27	27	NUM
easat-249	49	55	,	,	PUNCT
easat-249	49	56	no	no	INTJ
easat-249	49	57	.	.	NOUN
easat-249	49	58	1	1	NUM
easat-249	49	59	,	,	PUNCT
easat-249	49	60	pp	pp	ADJ
easat-249	49	61	.	.	PUNCT
easat-249	50	1	77	77	NUM
easat-249	50	2	-	-	SYM
easat-249	50	3	84	84	NUM
easat-249	50	4	,	,	PUNCT
easat-249	50	5	2006	2006	NUM
easat-249	50	6	.	.	PUNCT
easat-249	51	1	https://doi.org/10.1183/09031936.00029806	https://doi.org/10.1183/09031936.00029806	X
easat-249	51	2	[	[	X
easat-249	51	3	4	4	NUM
easat-249	51	4	]	]	PUNCT
easat-249	51	5	f.	f.	PROPN
easat-249	51	6	j.	j.	PROPN
easat-249	51	7	de	de	PROPN
easat-249	51	8	serres	serres	PROPN
easat-249	51	9	and	and	CCONJ
easat-249	51	10	i.	i.	PROPN
easat-249	51	11	blanco	blanco	PROPN
easat-249	51	12	,	,	PUNCT
easat-249	51	13	"	"	PUNCT
easat-249	51	14	pi	pi	NOUN
easat-249	51	15	s	s	NOUN
easat-249	51	16	and	and	CCONJ
easat-249	51	17	pi	pi	PROPN
easat-249	51	18	z	z	PROPN
easat-249	51	19	alpha-1	alpha-1	PROPN
easat-249	51	20	antitrypsin	antitrypsin	NOUN
easat-249	51	21	deficiency	deficiency	NOUN
easat-249	51	22	worldwide	worldwide	ADV
easat-249	51	23	.	.	PUNCT
easat-249	52	1	a	a	DET
easat-249	52	2	review	review	NOUN
easat-249	52	3	of	of	ADP
easat-249	52	4	existing	exist	VERB
easat-249	52	5	genetic	genetic	ADJ
easat-249	52	6	epidemiological	epidemiological	ADJ
easat-249	52	7	data	datum	NOUN
easat-249	52	8	,	,	PUNCT
easat-249	52	9	"	"	PUNCT
easat-249	52	10	monaldi	monaldi	ADJ
easat-249	52	11	archives	archive	NOUN
easat-249	52	12	for	for	ADP
easat-249	52	13	chest	chest	NOUN
easat-249	52	14	disease	disease	NOUN
easat-249	52	15	,	,	PUNCT
easat-249	52	16	vol	vol	NOUN
easat-249	52	17	.	.	PROPN
easat-249	52	18	67	67	NUM
easat-249	52	19	,	,	PUNCT
easat-249	52	20	no	no	INTJ
easat-249	52	21	.	.	NOUN
easat-249	52	22	4	4	NUM
easat-249	52	23	,	,	PUNCT
easat-249	52	24	pp	pp	ADJ
easat-249	52	25	.	.	PUNCT
easat-249	53	1	184	184	NUM
easat-249	53	2	-	-	SYM
easat-249	53	3	208	208	NUM
easat-249	53	4	,	,	PUNCT
easat-249	53	5	2007	2007	NUM
easat-249	53	6	.	.	PUNCT
easat-249	54	1	https://doi.org/10.4081/monaldi.2007.476	https://doi.org/10.4081/monaldi.2007.476	PROPN
easat-249	54	2	[	[	X
easat-249	54	3	5	5	NUM
easat-249	54	4	]	]	PUNCT
easat-249	54	5	f.	f.	PROPN
easat-249	54	6	j.	j.	PROPN
easat-249	54	7	de	de	PROPN
easat-249	54	8	serres	serres	PROPN
easat-249	54	9	,	,	PUNCT
easat-249	54	10	"	"	PUNCT
easat-249	54	11	worldwide	worldwide	ADV
easat-249	54	12	racial	racial	ADJ
easat-249	54	13	and	and	CCONJ
easat-249	54	14	ethnic	ethnic	ADJ
easat-249	54	15	distribution	distribution	NOUN
easat-249	54	16	of	of	ADP
easat-249	54	17	α1	α1	ADJ
easat-249	54	18	-	-	PUNCT
easat-249	54	19	antitrypsin	antitrypsin	NOUN
easat-249	54	20	deficiency	deficiency	NOUN
easat-249	54	21	:	:	PUNCT
easat-249	54	22	summary	summary	NOUN
easat-249	54	23	of	of	ADP
easat-249	54	24	an	an	DET
easat-249	54	25	analysis	analysis	NOUN
easat-249	54	26	of	of	ADP
easat-249	54	27	published	publish	VERB
easat-249	54	28	genetic	genetic	ADJ
easat-249	54	29	epidemiologic	epidemiologic	ADJ
easat-249	54	30	surveys	survey	NOUN
easat-249	54	31	,	,	PUNCT
easat-249	54	32	"	"	PUNCT
easat-249	54	33	chest	chest	NOUN
easat-249	54	34	,	,	PUNCT
easat-249	54	35	vol	vol	NOUN
easat-249	54	36	.	.	PROPN
easat-249	54	37	122	122	NUM
easat-249	54	38	,	,	PUNCT
easat-249	54	39	no	no	INTJ
easat-249	54	40	.	.	NOUN
easat-249	54	41	5	5	NUM
easat-249	54	42	,	,	PUNCT
easat-249	54	43	pp	pp	ADJ
easat-249	54	44	.	.	PUNCT
easat-249	54	45	1818	1818	NUM
easat-249	54	46	-	-	SYM
easat-249	54	47	1829	1829	NUM
easat-249	54	48	,	,	PUNCT
easat-249	54	49	2002	2002	NUM
easat-249	54	50	.	.	PUNCT
easat-249	55	1	https://doi.org/10.1378/chest.122.5.1818	https://doi.org/10.1378/chest.122.5.1818	VERB
easat-249	56	1	[	[	X
easat-249	56	2	6	6	NUM
easat-249	56	3	]	]	PUNCT
easat-249	56	4	d.	d.	PROPN
easat-249	56	5	a.	a.	PROPN
easat-249	56	6	lomas	lomas	PROPN
easat-249	56	7	,	,	PUNCT
easat-249	56	8	d.	d.	PROPN
easat-249	56	9	li	li	PROPN
easat-249	56	10	-	-	PROPN
easat-249	56	11	evans	evans	PROPN
easat-249	56	12	,	,	PUNCT
easat-249	56	13	j.	j.	PROPN
easat-249	56	14	t.	t.	PROPN
easat-249	56	15	finch	finch	PROPN
easat-249	56	16	,	,	PUNCT
easat-249	56	17	and	and	CCONJ
easat-249	56	18	r.	r.	PROPN
easat-249	56	19	w.	w.	PROPN
easat-249	56	20	carrell	carrell	PROPN
easat-249	56	21	,	,	PUNCT
easat-249	56	22	"	"	PUNCT
easat-249	56	23	the	the	DET
easat-249	56	24	mechanism	mechanism	NOUN
easat-249	56	25	of	of	ADP
easat-249	56	26	z	z	PROPN
easat-249	56	27	α	α	NOUN
easat-249	56	28	1	1	NUM
easat-249	56	29	-	-	PUNCT
easat-249	56	30	antitrypsin	antitrypsin	NOUN
easat-249	56	31	accumulation	accumulation	NOUN
easat-249	56	32	in	in	ADP
easat-249	56	33	the	the	DET
easat-249	56	34	liver	liver	NOUN
easat-249	56	35	,	,	PUNCT
easat-249	56	36	"	"	PUNCT
easat-249	56	37	nature	nature	NOUN
easat-249	56	38	,	,	PUNCT
easat-249	56	39	vol	vol	NOUN
easat-249	56	40	.	.	PROPN
easat-249	56	41	357	357	NUM
easat-249	56	42	,	,	PUNCT
easat-249	56	43	no	no	INTJ
easat-249	56	44	.	.	NOUN
easat-249	56	45	6379	6379	NUM
easat-249	56	46	,	,	PUNCT
easat-249	56	47	pp	pp	ADV
easat-249	56	48	.	.	PUNCT
easat-249	57	1	605	605	NUM
easat-249	57	2	-	-	SYM
easat-249	57	3	607	607	NUM
easat-249	57	4	,	,	PUNCT
easat-249	57	5	1992	1992	NUM
easat-249	57	6	.	.	PUNCT
easat-249	58	1	https://doi.org/10.1042/cs085030pa	https://doi.org/10.1042/cs085030pa	NOUN
easat-249	59	1	[	[	X
easat-249	59	2	7	7	NUM
easat-249	59	3	]	]	PUNCT
easat-249	59	4	r.	r.	PROPN
easat-249	59	5	mahadeva	mahadeva	PROPN
easat-249	59	6	et	et	PROPN
easat-249	59	7	al	al	PROPN
easat-249	59	8	.	.	PROPN
easat-249	59	9	,	,	PUNCT
easat-249	59	10	"	"	PUNCT
easat-249	59	11	heteropolymerization	heteropolymerization	NOUN
easat-249	59	12	of	of	ADP
easat-249	59	13	s	s	PROPN
easat-249	59	14	,	,	PUNCT
easat-249	59	15	i	i	PRON
easat-249	59	16	,	,	PUNCT
easat-249	59	17	and	and	CCONJ
easat-249	59	18	z	z	NOUN
easat-249	59	19	α	α	PRON
easat-249	59	20	1	1	NUM
easat-249	59	21	-	-	PUNCT
easat-249	59	22	antitrypsin	antitrypsin	NOUN
easat-249	59	23	and	and	CCONJ
easat-249	59	24	liver	liver	NOUN
easat-249	59	25	cirrhosis	cirrhosis	NOUN
easat-249	59	26	,	,	PUNCT
easat-249	59	27	"	"	PUNCT
easat-249	59	28	the	the	DET
easat-249	59	29	journal	journal	NOUN
easat-249	59	30	of	of	ADP
easat-249	59	31	clinical	clinical	ADJ
easat-249	59	32	investigation	investigation	NOUN
easat-249	59	33	,	,	PUNCT
easat-249	59	34	vol	vol	NOUN
easat-249	59	35	.	.	PROPN
easat-249	59	36	103	103	NUM
easat-249	59	37	,	,	PUNCT
easat-249	59	38	no	no	INTJ
easat-249	59	39	.	.	NOUN
easat-249	59	40	7	7	NUM
easat-249	59	41	,	,	PUNCT
easat-249	59	42	pp	pp	ADJ
easat-249	59	43	.	.	PUNCT
easat-249	60	1	999	999	NUM
easat-249	60	2	-	-	SYM
easat-249	60	3	1006	1006	NUM
easat-249	60	4	,	,	PUNCT
easat-249	60	5	1999	1999	NUM
easat-249	60	6	.	.	PUNCT
easat-249	61	1	https://doi.org/10.1172/jci4874	https://doi.org/10.1172/jci4874	PUNCT
easat-249	62	1	[	[	X
easat-249	62	2	8	8	NUM
easat-249	62	3	]	]	X
easat-249	62	4	d.	d.	PROPN
easat-249	62	5	lomas	lomas	PROPN
easat-249	62	6	and	and	CCONJ
easat-249	62	7	h.	h.	PROPN
easat-249	62	8	parfrey	parfrey	PROPN
easat-249	62	9	,	,	PUNCT
easat-249	62	10	"	"	PUNCT
easat-249	62	11	α1	α1	ADJ
easat-249	62	12	-	-	PUNCT
easat-249	62	13	antitrypsin	antitrypsin	NOUN
easat-249	62	14	deficiency•	deficiency•	NOUN
easat-249	62	15	4	4	NUM
easat-249	62	16	:	:	PUNCT
easat-249	62	17	molecular	molecular	ADJ
easat-249	62	18	pathophysiology	pathophysiology	NOUN
easat-249	62	19	,	,	PUNCT
easat-249	62	20	"	"	PUNCT
easat-249	62	21	thorax	thorax	NOUN
easat-249	62	22	,	,	PUNCT
easat-249	62	23	vol	vol	NOUN
easat-249	62	24	.	.	PROPN
easat-249	63	1	59	59	NUM
easat-249	63	2	,	,	PUNCT
easat-249	63	3	no	no	INTJ
easat-249	63	4	.	.	NOUN
easat-249	63	5	6	6	NUM
easat-249	63	6	,	,	PUNCT
easat-249	63	7	pp	pp	ADJ
easat-249	63	8	.	.	PUNCT
easat-249	64	1	529535	529535	NUM
easat-249	64	2	,	,	PUNCT
easat-249	64	3	2004	2004	NUM
easat-249	64	4	.	.	PUNCT
easat-249	65	1	[	[	X
easat-249	65	2	9	9	NUM
easat-249	65	3	]	]	PUNCT
easat-249	65	4	j.	j.	PROPN
easat-249	65	5	k.	k.	PROPN
easat-249	65	6	stoller	stoller	PROPN
easat-249	65	7	and	and	CCONJ
easat-249	65	8	l.	l.	PROPN
easat-249	65	9	s.	s.	PROPN
easat-249	65	10	aboussouan	aboussouan	PROPN
easat-249	65	11	,	,	PUNCT
easat-249	65	12	"	"	PUNCT
easat-249	65	13	a	a	DET
easat-249	65	14	review	review	NOUN
easat-249	65	15	of	of	ADP
easat-249	65	16	α1	α1	ADJ
easat-249	65	17	-	-	PUNCT
easat-249	65	18	antitrypsin	antitrypsin	NOUN
easat-249	65	19	deficiency	deficiency	NOUN
easat-249	65	20	,	,	PUNCT
easat-249	65	21	"	"	PUNCT
easat-249	65	22	american	american	ADJ
easat-249	65	23	journal	journal	NOUN
easat-249	65	24	of	of	ADP
easat-249	65	25	respiratory	respiratory	ADJ
easat-249	65	26	and	and	CCONJ
easat-249	65	27	critical	critical	ADJ
easat-249	65	28	care	care	NOUN
easat-249	65	29	medicine	medicine	NOUN
easat-249	65	30	,	,	PUNCT
easat-249	65	31	vol	vol	NOUN
easat-249	65	32	.	.	PROPN
easat-249	65	33	185	185	NUM
easat-249	65	34	,	,	PUNCT
easat-249	65	35	no	no	INTJ
easat-249	65	36	.	.	NOUN
easat-249	65	37	3	3	NUM
easat-249	65	38	,	,	PUNCT
easat-249	65	39	pp	pp	ADJ
easat-249	65	40	.	.	PUNCT
easat-249	65	41	246	246	NUM
easat-249	65	42	-	-	SYM
easat-249	65	43	259	259	NUM
easat-249	65	44	,	,	PUNCT
easat-249	65	45	2012	2012	NUM
easat-249	65	46	.	.	PUNCT
easat-249	66	1	[	[	X
easat-249	66	2	10	10	NUM
easat-249	66	3	]	]	X
easat-249	66	4	r.	r.	PROPN
easat-249	66	5	mahadeva	mahadeva	PROPN
easat-249	66	6	et	et	PROPN
easat-249	66	7	al	al	PROPN
easat-249	66	8	.	.	PROPN
easat-249	66	9	,	,	PUNCT
easat-249	66	10	"	"	PUNCT
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easat-249	66	12	of	of	ADP
easat-249	66	13	z	z	PROPN
easat-249	66	14	α1	α1	PROPN
easat-249	66	15	-	-	PUNCT
easat-249	66	16	antitrypsin	antitrypsin	NOUN
easat-249	66	17	co	co	NOUN
easat-249	66	18	-	-	NOUN
easat-249	66	19	localize	localize	VERB
easat-249	66	20	with	with	ADP
easat-249	66	21	neutrophils	neutrophil	NOUN
easat-249	66	22	in	in	ADP
easat-249	66	23	emphysematous	emphysematous	ADJ
easat-249	66	24	alveoli	alveoli	NOUN
easat-249	66	25	and	and	CCONJ
easat-249	66	26	are	be	AUX
easat-249	66	27	chemotactic	chemotactic	ADJ
easat-249	66	28	in	in	ADP
easat-249	66	29	vivo	vivo	NOUN
easat-249	66	30	,	,	PUNCT
easat-249	66	31	"	"	PUNCT
easat-249	66	32	the	the	DET
easat-249	66	33	american	american	PROPN
easat-249	66	34	journal	journal	PROPN
easat-249	66	35	of	of	ADP
easat-249	66	36	pathology	pathology	PROPN
easat-249	66	37	,	,	PUNCT
easat-249	66	38	vol	vol	NOUN
easat-249	66	39	.	.	PROPN
easat-249	66	40	166	166	NUM
easat-249	66	41	,	,	PUNCT
easat-249	66	42	no	no	INTJ
easat-249	66	43	.	.	NOUN
easat-249	66	44	2	2	NUM
easat-249	66	45	,	,	PUNCT
easat-249	66	46	pp	pp	ADJ
easat-249	66	47	.	.	PUNCT
easat-249	67	1	377	377	NUM
easat-249	67	2	-	-	SYM
easat-249	67	3	386	386	NUM
easat-249	67	4	,	,	PUNCT
easat-249	67	5	2005	2005	NUM
easat-249	67	6	.	.	PUNCT
easat-249	68	1	https://doi.org/10.1016/s0002-9440(10)62261-4	https://doi.org/10.1016/s0002-9440(10)62261-4	PROPN
easat-249	68	2	https://doi.org/10.1378/chest.128.4.1989	https://doi.org/10.1378/chest.128.4.1989	PROPN
easat-249	68	3	https://doi.org/10.1378/chest.128.3.1179	https://doi.org/10.1378/chest.128.3.1179	NOUN
easat-249	68	4	https://doi.org/10.1183/09031936.00029806	https://doi.org/10.1183/09031936.00029806	NOUN
easat-249	68	5	https://doi.org/10.4081/monaldi.2007.476	https://doi.org/10.4081/monaldi.2007.476	PROPN
easat-249	68	6	https://doi.org/10.1378/chest.122.5.1818	https://doi.org/10.1378/chest.122.5.1818	PROPN
easat-249	68	7	https://doi.org/10.1042/cs085030pa	https://doi.org/10.1042/cs085030pa	NOUN
easat-249	68	8	https://doi.org/10.1172/jci4874	https://doi.org/10.1172/jci4874	PROPN
easat-249	68	9	https://doi.org/10.1016/s0002-9440(10)62261-4	https://doi.org/10.1016/s0002-9440(10)62261-4	NOUN