id	sid	tid	token	lemma	pos
easat-261	1	1	edelweiss	edelweiss	PROPN
easat-261	1	2	applied	apply	VERB
easat-261	1	3	science	science	NOUN
easat-261	1	4	and	and	CCONJ
easat-261	1	5	technology	technology	NOUN
easat-261	1	6	issn	issn	PROPN
easat-261	1	7	:	:	PUNCT
easat-261	1	8	2576	2576	NUM
easat-261	1	9	-	-	SYM
easat-261	1	10	8484	8484	NUM
easat-261	1	11	vol	vol	NOUN
easat-261	1	12	.	.	PROPN
easat-261	2	1	3	3	NUM
easat-261	2	2	,	,	PUNCT
easat-261	2	3	no	no	INTJ
easat-261	2	4	.	.	NOUN
easat-261	2	5	1	1	NUM
easat-261	2	6	,	,	PUNCT
easat-261	2	7	18	18	NUM
easat-261	2	8	-	-	SYM
easat-261	2	9	19	19	NUM
easat-261	2	10	2019	2019	NUM
easat-261	2	11	doi	doi	NOUN
easat-261	2	12	:	:	PUNCT
easat-261	2	13	10.33805/2576.8484.162	10.33805/2576.8484.162	PROPN
easat-261	3	1	©	©	PROPN
easat-261	3	2	2019	2019	NUM
easat-261	3	3	by	by	ADP
easat-261	3	4	the	the	DET
easat-261	3	5	author	author	NOUN
easat-261	3	6	©	©	PROPN
easat-261	3	7	2019	2019	NUM
easat-261	3	8	by	by	ADP
easat-261	3	9	the	the	DET
easat-261	3	10	author	author	NOUN
easat-261	3	11	history	history	NOUN
easat-261	3	12	:	:	PUNCT
easat-261	3	13	received	receive	VERB
easat-261	3	14	:	:	PUNCT
easat-261	3	15	6	6	NUM
easat-261	3	16	february	february	NOUN
easat-261	3	17	2019	2019	NUM
easat-261	3	18	;	;	PUNCT
easat-261	3	19	accepted	accept	VERB
easat-261	3	20	:	:	PUNCT
easat-261	3	21	20	20	NUM
easat-261	3	22	february	february	NOUN
easat-261	3	23	2019	2019	NUM
easat-261	3	24	;	;	PUNCT
easat-261	3	25	published	publish	VERB
easat-261	3	26	:	:	PUNCT
easat-261	3	27	27	27	NUM
easat-261	3	28	february	february	PROPN
easat-261	3	29	2019	2019	NUM
easat-261	3	30	effective	effective	ADJ
easat-261	3	31	and	and	CCONJ
easat-261	3	32	safe	safe	ADJ
easat-261	3	33	fibrinolysis	fibrinolysis	NOUN
easat-261	3	34	requires	require	VERB
easat-261	3	35	both	both	DET
easat-261	3	36	plasminogen	plasminogen	NOUN
easat-261	3	37	activators	activator	NOUN
easat-261	3	38	in	in	ADP
easat-261	3	39	a	a	DET
easat-261	3	40	sequential	sequential	ADJ
easat-261	3	41	combination	combination	NOUN
easat-261	3	42	victor	victor	NOUN
easat-261	3	43	gurewich	gurewich	NOUN
easat-261	3	44	director	director	NOUN
easat-261	3	45	,	,	PUNCT
easat-261	3	46	vascular	vascular	ADJ
easat-261	3	47	research	research	NOUN
easat-261	3	48	laboratory	laboratory	NOUN
easat-261	3	49	,	,	PUNCT
easat-261	3	50	harvard	harvard	PROPN
easat-261	3	51	medical	medical	PROPN
easat-261	3	52	school	school	PROPN
easat-261	3	53	,	,	PUNCT
easat-261	3	54	mt	mt	PROPN
easat-261	3	55	auburn	auburn	PROPN
easat-261	3	56	hospital	hospital	PROPN
easat-261	3	57	,	,	PUNCT
easat-261	3	58	cambridge	cambridge	PROPN
easat-261	3	59	,	,	PUNCT
easat-261	3	60	massachusetts	massachusetts	PROPN
easat-261	3	61	,	,	PUNCT
easat-261	3	62	united	united	PROPN
easat-261	3	63	states	states	PROPN
easat-261	3	64	;	;	PUNCT
easat-261	4	1	vgurewich@tsillc.net	vgurewich@tsillc.net	PROPN
easat-261	4	2	(	(	PUNCT
easat-261	4	3	v.g	v.g	PROPN
easat-261	4	4	.	.	PROPN
easat-261	4	5	)	)	PUNCT
easat-261	4	6	.	.	PUNCT
easat-261	5	1	keywords	keyword	NOUN
easat-261	5	2	:	:	PUNCT
easat-261	5	3	fibrinolysis	fibrinolysis	NOUN
easat-261	5	4	,	,	PUNCT
easat-261	5	5	plasminogen	plasminogen	NOUN
easat-261	5	6	activators	activator	NOUN
easat-261	5	7	,	,	PUNCT
easat-261	5	8	tissue	tissue	NOUN
easat-261	5	9	plasminogen	plasminogen	NOUN
easat-261	5	10	activator	activator	NOUN
easat-261	5	11	,	,	PUNCT
easat-261	5	12	acute	acute	ADJ
easat-261	5	13	myocardial	myocardial	ADJ
easat-261	5	14	infarction	infarction	NOUN
easat-261	5	15	,	,	PUNCT
easat-261	5	16	percutaneous	percutaneous	ADJ
easat-261	5	17	coronary	coronary	ADJ
easat-261	5	18	intervention	intervention	NOUN
easat-261	5	19	.	.	PUNCT
easat-261	6	1	1	1	X
easat-261	6	2	.	.	X
easat-261	6	3	introduction	introduction	NOUN
easat-261	6	4	a	a	DET
easat-261	6	5	clot	clot	NOUN
easat-261	6	6	that	that	PRON
easat-261	6	7	obstructs	obstruct	VERB
easat-261	6	8	blood	blood	NOUN
easat-261	6	9	flow	flow	NOUN
easat-261	6	10	triggers	trigger	VERB
easat-261	6	11	the	the	DET
easat-261	6	12	onset	onset	NOUN
easat-261	6	13	of	of	ADP
easat-261	6	14	most	most	ADJ
easat-261	6	15	heart	heart	NOUN
easat-261	6	16	attacks	attack	NOUN
easat-261	6	17	and	and	CCONJ
easat-261	6	18	85	85	NUM
easat-261	6	19	%	%	NOUN
easat-261	6	20	of	of	ADP
easat-261	6	21	strokes	stroke	NOUN
easat-261	6	22	,	,	PUNCT
easat-261	6	23	the	the	DET
easat-261	6	24	leading	lead	VERB
easat-261	6	25	causes	cause	NOUN
easat-261	6	26	of	of	ADP
easat-261	6	27	death	death	NOUN
easat-261	6	28	and	and	CCONJ
easat-261	6	29	disability	disability	NOUN
easat-261	6	30	worldwide	worldwide	ADV
easat-261	6	31	.	.	PUNCT
easat-261	7	1	reestablishing	reestablish	VERB
easat-261	7	2	blood	blood	NOUN
easat-261	7	3	flow	flow	NOUN
easat-261	7	4	rapidly	rapidly	ADV
easat-261	7	5	limits	limit	VERB
easat-261	7	6	damage	damage	NOUN
easat-261	7	7	to	to	ADP
easat-261	7	8	the	the	DET
easat-261	7	9	heart	heart	NOUN
easat-261	7	10	or	or	CCONJ
easat-261	7	11	brain	brain	NOUN
easat-261	7	12	,	,	PUNCT
easat-261	7	13	saves	save	VERB
easat-261	7	14	lives	life	NOUN
easat-261	7	15	,	,	PUNCT
easat-261	7	16	and	and	CCONJ
easat-261	7	17	can	can	AUX
easat-261	7	18	restore	restore	VERB
easat-261	7	19	well	well	ADV
easat-261	7	20	-	-	PUNCT
easat-261	7	21	being	being	NOUN
easat-261	7	22	.	.	PUNCT
easat-261	8	1	since	since	SCONJ
easat-261	8	2	“	"	PUNCT
easat-261	8	3	time	time	NOUN
easat-261	8	4	is	be	AUX
easat-261	8	5	heart	heart	NOUN
easat-261	8	6	or	or	CCONJ
easat-261	8	7	brain	brain	NOUN
easat-261	8	8	,	,	PUNCT
easat-261	8	9	”	"	PUNCT
easat-261	8	10	treatment	treatment	NOUN
easat-261	8	11	must	must	AUX
easat-261	8	12	be	be	AUX
easat-261	8	13	initiated	initiate	VERB
easat-261	8	14	rapidly	rapidly	ADV
easat-261	8	15	,	,	PUNCT
easat-261	8	16	which	which	PRON
easat-261	8	17	means	mean	VERB
easat-261	8	18	by	by	ADP
easat-261	8	19	a	a	DET
easat-261	8	20	readily	readily	ADV
easat-261	8	21	available	available	ADJ
easat-261	8	22	method	method	NOUN
easat-261	8	23	.	.	PUNCT
easat-261	9	1	fibrinolysis	fibrinolysis	NOUN
easat-261	9	2	is	be	AUX
easat-261	9	3	the	the	DET
easat-261	9	4	only	only	ADJ
easat-261	9	5	therapy	therapy	NOUN
easat-261	9	6	able	able	ADJ
easat-261	9	7	to	to	PART
easat-261	9	8	fulfill	fulfill	VERB
easat-261	9	9	these	these	DET
easat-261	9	10	criteria	criterion	NOUN
easat-261	9	11	but	but	CCONJ
easat-261	9	12	the	the	DET
easat-261	9	13	current	current	ADJ
easat-261	9	14	method	method	NOUN
easat-261	9	15	using	use	VERB
easat-261	9	16	tissue	tissue	NOUN
easat-261	9	17	plasminogen	plasminogen	NOUN
easat-261	9	18	activator	activator	NOUN
easat-261	9	19	(	(	PUNCT
easat-261	9	20	tpa	tpa	NOUN
easat-261	9	21	)	)	PUNCT
easat-261	9	22	monotherapy	monotherapy	NOUN
easat-261	9	23	is	be	AUX
easat-261	9	24	not	not	PART
easat-261	9	25	sufficiently	sufficiently	ADV
easat-261	9	26	safe	safe	ADJ
easat-261	9	27	to	to	PART
easat-261	9	28	be	be	AUX
easat-261	9	29	administered	administer	VERB
easat-261	9	30	without	without	ADP
easat-261	9	31	pre	pre	ADJ
easat-261	9	32	-	-	ADJ
easat-261	9	33	testing	testing	NOUN
easat-261	9	34	nor	nor	CCONJ
easat-261	9	35	is	be	AUX
easat-261	9	36	it	it	PRON
easat-261	9	37	sufficiently	sufficiently	ADV
easat-261	9	38	effective	effective	ADJ
easat-261	9	39	to	to	PART
easat-261	9	40	be	be	AUX
easat-261	9	41	very	very	ADV
easat-261	9	42	useful	useful	ADJ
easat-261	9	43	.	.	PUNCT
easat-261	10	1	although	although	SCONJ
easat-261	10	2	anticoagulants	anticoagulant	NOUN
easat-261	10	3	have	have	AUX
easat-261	10	4	evolved	evolve	VERB
easat-261	10	5	,	,	PUNCT
easat-261	10	6	especially	especially	ADV
easat-261	10	7	in	in	ADP
easat-261	10	8	recent	recent	ADJ
easat-261	10	9	years	year	NOUN
easat-261	10	10	,	,	PUNCT
easat-261	10	11	the	the	DET
easat-261	10	12	same	same	ADJ
easat-261	10	13	thrombolytic	thrombolytic	NOUN
easat-261	10	14	has	have	AUX
easat-261	10	15	been	be	AUX
easat-261	10	16	used	use	VERB
easat-261	10	17	since	since	SCONJ
easat-261	10	18	1987	1987	NUM
easat-261	10	19	,	,	PUNCT
easat-261	10	20	when	when	SCONJ
easat-261	10	21	tpa	tpa	PROPN
easat-261	10	22	monotherapy	monotherapy	NOUN
easat-261	10	23	was	be	AUX
easat-261	10	24	approved	approve	VERB
easat-261	10	25	for	for	ADP
easat-261	10	26	the	the	DET
easat-261	10	27	treatment	treatment	NOUN
easat-261	10	28	of	of	ADP
easat-261	10	29	acute	acute	ADJ
easat-261	10	30	myocardial	myocardial	ADJ
easat-261	10	31	infarction	infarction	NOUN
easat-261	10	32	(	(	PUNCT
easat-261	10	33	ami	ami	NOUN
easat-261	10	34	)	)	PUNCT
easat-261	10	35	and	and	CCONJ
easat-261	10	36	subsequently	subsequently	ADV
easat-261	10	37	also	also	ADV
easat-261	10	38	for	for	ADP
easat-261	10	39	ischemic	ischemic	ADJ
easat-261	10	40	stroke	stroke	NOUN
easat-261	10	41	.	.	PUNCT
easat-261	11	1	however	however	ADV
easat-261	11	2	,	,	PUNCT
easat-261	11	3	the	the	DET
easat-261	11	4	clinical	clinical	ADJ
easat-261	11	5	results	result	NOUN
easat-261	11	6	with	with	ADP
easat-261	11	7	tpa	tpa	NOUN
easat-261	11	8	given	give	VERB
easat-261	11	9	within	within	ADP
easat-261	11	10	the	the	DET
easat-261	11	11	time	time	NOUN
easat-261	11	12	window	window	NOUN
easat-261	11	13	was	be	AUX
easat-261	11	14	never	never	ADV
easat-261	11	15	shown	show	VERB
easat-261	11	16	to	to	PART
easat-261	11	17	be	be	AUX
easat-261	11	18	significantly	significantly	ADV
easat-261	11	19	better	well	ADJ
easat-261	11	20	than	than	ADP
easat-261	11	21	those	those	PRON
easat-261	11	22	obtained	obtain	VERB
easat-261	11	23	with	with	ADP
easat-261	11	24	the	the	DET
easat-261	11	25	previous	previous	ADJ
easat-261	11	26	thrombolytic	thrombolytic	ADJ
easat-261	11	27	,	,	PUNCT
easat-261	11	28	streptokinase	streptokinase	PROPN
easat-261	11	29	(	(	PUNCT
easat-261	11	30	sk	sk	PROPN
easat-261	11	31	)	)	PUNCT
easat-261	12	1	[	[	X
easat-261	12	2	1	1	X
easat-261	12	3	]	]	PUNCT
easat-261	12	4	moreover	moreover	ADV
easat-261	12	5	tpa	tpa	PROPN
easat-261	12	6	caused	cause	VERB
easat-261	12	7	more	more	ADJ
easat-261	12	8	bleeding	bleeding	ADJ
easat-261	12	9	side	side	NOUN
easat-261	12	10	effects	effect	NOUN
easat-261	12	11	than	than	ADP
easat-261	12	12	sk	sk	PROPN
easat-261	12	13	.	.	PUNCT
easat-261	13	1	when	when	SCONJ
easat-261	13	2	tpa	tpa	PROPN
easat-261	13	3	is	be	AUX
easat-261	13	4	used	use	VERB
easat-261	13	5	for	for	ADP
easat-261	13	6	ischemic	ischemic	ADJ
easat-261	13	7	stroke	stroke	NOUN
easat-261	13	8	there	there	PRON
easat-261	13	9	is	be	VERB
easat-261	13	10	a	a	DET
easat-261	13	11	6	6	NUM
easat-261	13	12	-	-	SYM
easat-261	13	13	7	7	NUM
easat-261	13	14	%	%	NOUN
easat-261	13	15	incidence	incidence	NOUN
easat-261	13	16	of	of	ADP
easat-261	13	17	symptomatic	symptomatic	ADJ
easat-261	13	18	intracranial	intracranial	ADJ
easat-261	13	19	hemorrhage	hemorrhage	NOUN
easat-261	13	20	complications	complication	NOUN
easat-261	13	21	[	[	X
easat-261	13	22	2	2	NUM
easat-261	13	23	]	]	PUNCT
easat-261	13	24	.	.	PUNCT
easat-261	14	1	as	as	ADP
easat-261	14	2	a	a	DET
easat-261	14	3	result	result	NOUN
easat-261	14	4	,	,	PUNCT
easat-261	14	5	tpa	tpa	PROPN
easat-261	14	6	has	have	AUX
easat-261	14	7	recently	recently	ADV
easat-261	14	8	been	be	AUX
easat-261	14	9	replaced	replace	VERB
easat-261	14	10	,	,	PUNCT
easat-261	14	11	not	not	PART
easat-261	14	12	by	by	ADP
easat-261	14	13	another	another	DET
easat-261	14	14	thrombolytic	thrombolytic	ADJ
easat-261	14	15	,	,	PUNCT
easat-261	14	16	but	but	CCONJ
easat-261	14	17	by	by	ADP
easat-261	14	18	percutaneous	percutaneous	ADJ
easat-261	14	19	coronary	coronary	ADJ
easat-261	14	20	intervention	intervention	NOUN
easat-261	14	21	(	(	PUNCT
easat-261	14	22	pci	pci	PROPN
easat-261	14	23	)	)	PUNCT
easat-261	14	24	,	,	PUNCT
easat-261	14	25	a	a	DET
easat-261	14	26	method	method	NOUN
easat-261	14	27	that	that	PRON
easat-261	14	28	is	be	AUX
easat-261	14	29	costly	costly	ADJ
easat-261	14	30	and	and	CCONJ
easat-261	14	31	time	time	NOUN
easat-261	14	32	-	-	PUNCT
easat-261	14	33	consuming	consume	VERB
easat-261	14	34	.	.	PUNCT
easat-261	15	1	nevertheless	nevertheless	ADV
easat-261	15	2	,	,	PUNCT
easat-261	15	3	the	the	DET
easat-261	15	4	results	result	NOUN
easat-261	15	5	of	of	ADP
easat-261	15	6	pci	pci	PROPN
easat-261	15	7	were	be	AUX
easat-261	15	8	superior	superior	ADJ
easat-261	15	9	to	to	ADP
easat-261	15	10	those	those	PRON
easat-261	15	11	obtained	obtain	VERB
easat-261	15	12	with	with	ADP
easat-261	15	13	tpa	tpa	PROPN
easat-261	15	14	.	.	PUNCT
easat-261	16	1	in	in	ADP
easat-261	16	2	stroke	stroke	PROPN
easat-261	16	3	,	,	PUNCT
easat-261	16	4	tpa	tpa	PROPN
easat-261	16	5	is	be	AUX
easat-261	16	6	used	use	VERB
easat-261	16	7	in	in	ADP
easat-261	16	8	only	only	ADV
easat-261	16	9	about	about	ADV
easat-261	16	10	5	5	NUM
easat-261	16	11	%	%	NOUN
easat-261	16	12	of	of	ADP
easat-261	16	13	patients	patient	NOUN
easat-261	16	14	because	because	SCONJ
easat-261	16	15	of	of	ADP
easat-261	16	16	its	its	PRON
easat-261	16	17	limited	limited	ADJ
easat-261	16	18	efficacy	efficacy	NOUN
easat-261	16	19	and	and	CCONJ
easat-261	16	20	hazard	hazard	NOUN
easat-261	16	21	.	.	PUNCT
easat-261	17	1	tpa	tpa	PROPN
easat-261	17	2	is	be	AUX
easat-261	17	3	part	part	NOUN
easat-261	17	4	of	of	ADP
easat-261	17	5	the	the	DET
easat-261	17	6	body	body	NOUN
easat-261	17	7	’s	’s	PART
easat-261	17	8	natural	natural	ADJ
easat-261	17	9	thrombolytic	thrombolytic	ADJ
easat-261	17	10	system	system	NOUN
easat-261	17	11	that	that	PRON
easat-261	17	12	controls	control	VERB
easat-261	17	13	the	the	DET
easat-261	17	14	size	size	NOUN
easat-261	17	15	of	of	ADP
easat-261	17	16	“	"	PUNCT
easat-261	17	17	good	good	ADJ
easat-261	17	18	”	"	PUNCT
easat-261	17	19	blood	blood	NOUN
easat-261	17	20	clots	clot	NOUN
easat-261	17	21	needed	need	VERB
easat-261	17	22	to	to	PART
easat-261	17	23	stop	stop	VERB
easat-261	17	24	bleeding	bleed	VERB
easat-261	17	25	,	,	PUNCT
easat-261	17	26	and	and	CCONJ
easat-261	17	27	which	which	PRON
easat-261	17	28	is	be	AUX
easat-261	17	29	also	also	ADV
easat-261	17	30	needed	need	VERB
easat-261	17	31	for	for	ADP
easat-261	17	32	the	the	DET
easat-261	17	33	repair	repair	NOUN
easat-261	17	34	of	of	ADP
easat-261	17	35	“	"	PUNCT
easat-261	17	36	wear	wear	VERB
easat-261	17	37	and	and	CCONJ
easat-261	17	38	tear	tear	ADJ
easat-261	17	39	”	"	PUNCT
easat-261	17	40	injuries	injury	NOUN
easat-261	17	41	of	of	ADP
easat-261	17	42	blood	blood	NOUN
easat-261	17	43	vessels	vessel	NOUN
easat-261	17	44	.	.	PUNCT
easat-261	18	1	in	in	ADP
easat-261	18	2	this	this	DET
easat-261	18	3	system	system	NOUN
easat-261	18	4	,	,	PUNCT
easat-261	18	5	tpa	tpa	PROPN
easat-261	18	6	is	be	AUX
easat-261	18	7	remarkably	remarkably	ADV
easat-261	18	8	effective	effective	ADJ
easat-261	18	9	,	,	PUNCT
easat-261	18	10	in	in	ADP
easat-261	18	11	contrast	contrast	NOUN
easat-261	18	12	to	to	ADP
easat-261	18	13	its	its	PRON
easat-261	18	14	relatively	relatively	ADV
easat-261	18	15	poor	poor	ADJ
easat-261	18	16	efficacy	efficacy	NOUN
easat-261	18	17	in	in	ADP
easat-261	18	18	therapy	therapy	NOUN
easat-261	18	19	.	.	PUNCT
easat-261	19	1	this	this	DET
easat-261	19	2	discrepancy	discrepancy	NOUN
easat-261	19	3	is	be	AUX
easat-261	19	4	explained	explain	VERB
easat-261	19	5	by	by	ADP
easat-261	19	6	the	the	DET
easat-261	19	7	presence	presence	NOUN
easat-261	19	8	of	of	ADP
easat-261	19	9	the	the	DET
easat-261	19	10	other	other	ADJ
easat-261	19	11	thrombolytic	thrombolytic	ADJ
easat-261	19	12	,	,	PUNCT
easat-261	19	13	urokinase	urokinase	NOUN
easat-261	19	14	plasminogen	plasminogen	NOUN
easat-261	19	15	activator	activator	NOUN
easat-261	19	16	or	or	CCONJ
easat-261	19	17	upa	upa	NOUN
easat-261	19	18	,	,	PUNCT
easat-261	19	19	in	in	ADP
easat-261	19	20	the	the	DET
easat-261	19	21	natural	natural	ADJ
easat-261	19	22	system	system	NOUN
easat-261	19	23	.	.	PUNCT
easat-261	20	1	2	2	X
easat-261	20	2	.	.	X
easat-261	20	3	the	the	DET
easat-261	20	4	fibrinolytic	fibrinolytic	ADJ
easat-261	20	5	system	system	NOUN
easat-261	20	6	in	in	ADP
easat-261	20	7	the	the	DET
easat-261	20	8	biological	biological	ADJ
easat-261	20	9	system	system	NOUN
easat-261	20	10	,	,	PUNCT
easat-261	20	11	tpa	tpa	PROPN
easat-261	20	12	is	be	AUX
easat-261	20	13	found	find	VERB
easat-261	20	14	in	in	ADP
easat-261	20	15	the	the	DET
easat-261	20	16	vessel	vessel	NOUN
easat-261	20	17	wall	wall	NOUN
easat-261	20	18	,	,	PUNCT
easat-261	20	19	and	and	CCONJ
easat-261	20	20	in	in	ADP
easat-261	20	21	the	the	DET
easat-261	20	22	event	event	NOUN
easat-261	20	23	of	of	ADP
easat-261	20	24	an	an	DET
easat-261	20	25	obstructive	obstructive	ADJ
easat-261	20	26	thrombus	thrombus	NOUN
easat-261	20	27	,	,	PUNCT
easat-261	20	28	it	it	PRON
easat-261	20	29	is	be	AUX
easat-261	20	30	released	release	VERB
easat-261	20	31	at	at	ADP
easat-261	20	32	that	that	DET
easat-261	20	33	site	site	NOUN
easat-261	20	34	.	.	PUNCT
easat-261	21	1	due	due	ADP
easat-261	21	2	to	to	ADP
easat-261	21	3	its	its	PRON
easat-261	21	4	high	high	ADJ
easat-261	21	5	fibrin	fibrin	NOUN
easat-261	21	6	affinity	affinity	NOUN
easat-261	21	7	,	,	PUNCT
easat-261	21	8	mediated	mediate	VERB
easat-261	21	9	by	by	ADP
easat-261	21	10	both	both	DET
easat-261	21	11	its	its	PRON
easat-261	21	12	finger	finger	NOUN
easat-261	21	13	and	and	CCONJ
easat-261	21	14	kringle	kringle	NOUN
easat-261	21	15	domains	domain	NOUN
easat-261	21	16	,	,	PUNCT
easat-261	21	17	tpa	tpa	PROPN
easat-261	21	18	binds	bind	VERB
easat-261	21	19	to	to	ADP
easat-261	21	20	the	the	DET
easat-261	21	21	fibr	fibr	NOUN
easat-261	21	22	in	in	ADP
easat-261	21	23	clot	clot	NOUN
easat-261	21	24	,	,	PUNCT
easat-261	21	25	and	and	CCONJ
easat-261	21	26	activates	activate	VERB
easat-261	21	27	an	an	DET
easat-261	21	28	adjacent	adjacent	ADJ
easat-261	21	29	fibrin	fibrin	NOUN
easat-261	21	30	-	-	PUNCT
easat-261	21	31	bound	bind	VERB
easat-261	21	32	plasminogen	plasminogen	NOUN
easat-261	21	33	[	[	X
easat-261	21	34	3	3	NUM
easat-261	21	35	]	]	PUNCT
easat-261	21	36	thereby	thereby	ADV
easat-261	21	37	initiating	initiate	VERB
easat-261	21	38	fibrinolysis	fibrinolysis	NOUN
easat-261	21	39	.	.	PUNCT
easat-261	22	1	this	this	DET
easat-261	22	2	fibrin	fibrin	NOUN
easat-261	22	3	degradation	degradation	NOUN
easat-261	22	4	exposes	expose	VERB
easat-261	22	5	two	two	NUM
easat-261	22	6	new	new	ADJ
easat-261	22	7	plasminogen	plasminogen	NOUN
easat-261	22	8	binding	bind	VERB
easat-261	22	9	sites	site	NOUN
easat-261	22	10	on	on	ADP
easat-261	22	11	the	the	DET
easat-261	22	12	fibrin	fibrin	NOUN
easat-261	22	13	surface	surface	NOUN
easat-261	22	14	.	.	PUNCT
easat-261	23	1	since	since	SCONJ
easat-261	23	2	tpa	tpa	PROPN
easat-261	23	3	has	have	VERB
easat-261	23	4	only	only	ADV
easat-261	23	5	a	a	DET
easat-261	23	6	single	single	ADJ
easat-261	23	7	fibrin	fibrin	NOUN
easat-261	23	8	binding	bind	VERB
easat-261	23	9	site	site	NOUN
easat-261	23	10	on	on	ADP
easat-261	23	11	the	the	DET
easat-261	23	12	fibrin	fibrin	NOUN
easat-261	23	13	d	d	NOUN
easat-261	23	14	-	-	NOUN
easat-261	23	15	domain	domain	NOUN
easat-261	23	16	,	,	PUNCT
easat-261	23	17	it	it	PRON
easat-261	23	18	can	can	AUX
easat-261	23	19	not	not	PART
easat-261	23	20	activate	activate	VERB
easat-261	23	21	the	the	DET
easat-261	23	22	plasminogen	plasminogen	NOUN
easat-261	23	23	on	on	ADP
easat-261	23	24	these	these	DET
easat-261	23	25	new	new	ADJ
easat-261	23	26	sites	site	NOUN
easat-261	23	27	which	which	PRON
easat-261	23	28	are	be	AUX
easat-261	23	29	on	on	ADP
easat-261	23	30	the	the	DET
easat-261	23	31	fibrin	fibrin	NOUN
easat-261	23	32	e	e	NOUN
easat-261	23	33	-	-	NOUN
easat-261	23	34	domain	domain	NOUN
easat-261	23	35	.	.	PUNCT
easat-261	24	1	only	only	ADV
easat-261	24	2	at	at	ADP
easat-261	24	3	very	very	ADV
easat-261	24	4	high	high	ADJ
easat-261	24	5	doses	dose	NOUN
easat-261	24	6	,	,	PUNCT
easat-261	24	7	at	at	ADP
easat-261	24	8	which	which	PRON
easat-261	24	9	tpa	tpa	NOUN
easat-261	24	10	is	be	AUX
easat-261	24	11	no	no	ADV
easat-261	24	12	longer	long	ADV
easat-261	24	13	fibrin	fibrin	NOUN
easat-261	24	14	-	-	PUNCT
easat-261	24	15	specific	specific	ADJ
easat-261	24	16	,	,	PUNCT
easat-261	24	17	can	can	AUX
easat-261	24	18	tpa	tpa	NOUN
easat-261	24	19	activate	activate	VERB
easat-261	24	20	these	these	DET
easat-261	24	21	new	new	ADJ
easat-261	24	22	plasminogens	plasminogen	NOUN
easat-261	24	23	.	.	PUNCT
easat-261	25	1	instead	instead	ADV
easat-261	25	2	,	,	PUNCT
easat-261	25	3	the	the	DET
easat-261	25	4	first	first	ADJ
easat-261	25	5	of	of	ADP
easat-261	25	6	these	these	DET
easat-261	25	7	new	new	ADJ
easat-261	25	8	plasminogens	plasminogen	NOUN
easat-261	25	9	is	be	AUX
easat-261	25	10	activated	activate	VERB
easat-261	25	11	not	not	PART
easat-261	25	12	by	by	ADP
easat-261	25	13	tpa	tpa	PROPN
easat-261	25	14	but	but	CCONJ
easat-261	25	15	rather	rather	ADV
easat-261	25	16	by	by	ADP
easat-261	25	17	prourokinase	prourokinase	NOUN
easat-261	25	18	(	(	PUNCT
easat-261	25	19	prouk	prouk	PROPN
easat-261	25	20	)	)	PUNCT
easat-261	25	21	,	,	PUNCT
easat-261	25	22	which	which	PRON
easat-261	25	23	has	have	VERB
easat-261	25	24	a	a	DET
easat-261	25	25	high	high	ADJ
easat-261	25	26	substrate	substrate	NOUN
easat-261	25	27	affinity	affinity	NOUN
easat-261	25	28	for	for	ADP
easat-261	25	29	plasminogen	plasminogen	NOUN
easat-261	25	30	on	on	ADP
easat-261	25	31	the	the	DET
easat-261	25	32	fibrin	fibrin	NOUN
easat-261	25	33	e	e	NOUN
easat-261	25	34	-	-	NOUN
easat-261	25	35	domain	domain	NOUN
easat-261	25	36	.	.	PUNCT
easat-261	26	1	activation	activation	NOUN
easat-261	26	2	of	of	ADP
easat-261	26	3	this	this	DET
easat-261	26	4	plasminogen	plasminogen	NOUN
easat-261	26	5	is	be	AUX
easat-261	26	6	followed	follow	VERB
easat-261	26	7	by	by	ADP
easat-261	26	8	the	the	DET
easat-261	26	9	reciprocal	reciprocal	ADJ
easat-261	26	10	activation	activation	NOUN
easat-261	26	11	of	of	ADP
easat-261	26	12	prouk	prouk	NOUN
easat-261	26	13	to	to	ADP
easat-261	26	14	uk	uk	PROPN
easat-261	26	15	by	by	ADP
easat-261	26	16	plasmin	plasmin	PROPN
easat-261	26	17	.	.	PUNCT
easat-261	27	1	the	the	DET
easat-261	27	2	uk	uk	PROPN
easat-261	27	3	then	then	ADV
easat-261	27	4	activates	activate	VERB
easat-261	27	5	the	the	DET
easat-261	27	6	remaining	remain	VERB
easat-261	27	7	plasminogen	plasminogen	NOUN
easat-261	27	8	completing	complete	VERB
easat-261	27	9	fibrinolysis	fibrinolysis	NOUN
easat-261	27	10	[	[	X
easat-261	27	11	3	3	NUM
easat-261	27	12	]	]	PUNCT
easat-261	27	13	.	.	PUNCT
easat-261	28	1	therefore	therefore	ADV
easat-261	28	2	,	,	PUNCT
easat-261	28	3	fibrinolysis	fibrinolysis	NOUN
easat-261	28	4	involves	involve	VERB
easat-261	28	5	the	the	DET
easat-261	28	6	sequential	sequential	ADJ
easat-261	28	7	effects	effect	NOUN
easat-261	28	8	of	of	ADP
easat-261	28	9	both	both	DET
easat-261	28	10	plasminogen	plasminogen	NOUN
easat-261	28	11	activators	activator	NOUN
easat-261	28	12	with	with	ADP
easat-261	28	13	tpa	tpa	PROPN
easat-261	28	14	initiation	initiation	NOUN
easat-261	28	15	of	of	ADP
easat-261	28	16	lysis	lysis	NOUN
easat-261	28	17	and	and	CCONJ
easat-261	28	18	prouk	prouk	NOUN
easat-261	28	19	/	/	SYM
easat-261	28	20	uk	uk	PROPN
easat-261	28	21	continuing	continue	VERB
easat-261	28	22	and	and	CCONJ
easat-261	28	23	completing	complete	VERB
easat-261	28	24	it	it	PRON
easat-261	28	25	.	.	PUNCT
easat-261	29	1	as	as	ADP
easat-261	29	2	a	a	DET
easat-261	29	3	result	result	NOUN
easat-261	29	4	,	,	PUNCT
easat-261	29	5	tpa	tpa	PROPN
easat-261	29	6	is	be	AUX
easat-261	29	7	responsible	responsible	ADJ
easat-261	29	8	for	for	ADP
easat-261	29	9	33	33	NUM
easat-261	29	10	%	%	NOUN
easat-261	29	11	of	of	ADP
easat-261	29	12	the	the	DET
easat-261	29	13	process	process	NOUN
easat-261	29	14	and	and	CCONJ
easat-261	29	15	prouk	prouk	VERB
easat-261	29	16	/	/	SYM
easat-261	29	17	uk	uk	PROPN
easat-261	29	18	the	the	DET
easat-261	29	19	remaining	remain	VERB
easat-261	29	20	66	66	NUM
easat-261	29	21	%	%	NOUN
easat-261	29	22	.	.	PUNCT
easat-261	30	1	the	the	DET
easat-261	30	2	dominant	dominant	ADJ
easat-261	30	3	role	role	NOUN
easat-261	30	4	of	of	ADP
easat-261	30	5	prouk	prouk	NOUN
easat-261	30	6	in	in	ADP
easat-261	30	7	fibrinolysis	fibrinolysis	NOUN
easat-261	30	8	has	have	AUX
easat-261	30	9	been	be	AUX
easat-261	30	10	generally	generally	ADV
easat-261	30	11	over	over	ADV
easat-261	30	12	looked	look	VERB
easat-261	30	13	,	,	PUNCT
easat-261	30	14	which	which	PRON
easat-261	30	15	may	may	AUX
easat-261	30	16	be	be	AUX
easat-261	30	17	explained	explain	VERB
easat-261	30	18	by	by	ADP
easat-261	30	19	the	the	DET
easat-261	30	20	fact	fact	NOUN
easat-261	30	21	that	that	SCONJ
easat-261	30	22	most	most	ADJ
easat-261	30	23	of	of	ADP
easat-261	30	24	it	it	PRON
easat-261	30	25	is	be	AUX
easat-261	30	26	carried	carry	VERB
easat-261	30	27	on	on	ADP
easat-261	30	28	the	the	DET
easat-261	30	29	surface	surface	NOUN
easat-261	30	30	of	of	ADP
easat-261	30	31	platelets	platelet	NOUN
easat-261	30	32	to	to	PART
easat-261	30	33	which	which	PRON
easat-261	30	34	prouk	prouk	VERB
easat-261	30	35	is	be	AUX
easat-261	30	36	tightly	tightly	ADV
easat-261	30	37	bound	bind	VERB
easat-261	30	38	and	and	CCONJ
easat-261	30	39	where	where	SCONJ
easat-261	30	40	it	it	PRON
easat-261	30	41	is	be	AUX
easat-261	30	42	fibrinolytically	fibrinolytically	ADV
easat-261	30	43	active	active	ADJ
easat-261	30	44	[	[	X
easat-261	30	45	4	4	NUM
easat-261	30	46	]	]	PUNCT
easat-261	30	47	.	.	PUNCT
easat-261	31	1	unfortunately	unfortunately	ADV
easat-261	31	2	,	,	PUNCT
easat-261	31	3	since	since	SCONJ
easat-261	31	4	prouk	prouk	NOUN
easat-261	31	5	was	be	AUX
easat-261	31	6	ignored	ignore	VERB
easat-261	31	7	,	,	PUNCT
easat-261	31	8	therapeutic	therapeutic	ADJ
easat-261	31	9	fibrinolysis	fibrinolysis	NOUN
easat-261	31	10	has	have	AUX
easat-261	31	11	consisted	consist	VERB
easat-261	31	12	of	of	ADP
easat-261	31	13	tpa	tpa	NOUN
easat-261	31	14	alone	alone	ADJ
easat-261	31	15	for	for	ADP
easat-261	31	16	the	the	DET
easat-261	31	17	past	past	ADJ
easat-261	31	18	32	32	NUM
easat-261	31	19	years	year	NOUN
easat-261	31	20	.	.	PUNCT
easat-261	32	1	however	however	ADV
easat-261	32	2	,	,	PUNCT
easat-261	32	3	since	since	SCONJ
easat-261	32	4	tpa	tpa	PROPN
easat-261	32	5	’s	’s	PART
easat-261	32	6	function	function	NOUN
easat-261	32	7	is	be	AUX
easat-261	32	8	limited	limit	VERB
easat-261	32	9	to	to	ADP
easat-261	32	10	the	the	DET
easat-261	32	11	initiation	initiation	NOUN
easat-261	32	12	of	of	ADP
easat-261	32	13	fibrinolysis	fibrinolysis	NOUN
easat-261	32	14	,	,	PUNCT
easat-261	32	15	its	its	PRON
easat-261	32	16	therapeutic	therapeutic	ADJ
easat-261	32	17	effect	effect	NOUN
easat-261	32	18	has	have	AUX
easat-261	32	19	always	always	ADV
easat-261	32	20	been	be	AUX
easat-261	32	21	a	a	DET
easat-261	32	22	disappointment	disappointment	NOUN
easat-261	32	23	being	be	AUX
easat-261	32	24	somewhat	somewhat	ADV
easat-261	32	25	analogous	analogous	ADJ
easat-261	32	26	to	to	ADP
easat-261	32	27	trying	try	VERB
easat-261	32	28	to	to	PART
easat-261	32	29	run	run	VERB
easat-261	32	30	a	a	DET
easat-261	32	31	car	car	NOUN
easat-261	32	32	on	on	ADP
easat-261	32	33	the	the	DET
easat-261	32	34	starter	starter	ADJ
easat-261	32	35	motor	motor	NOUN
easat-261	32	36	alone	alone	ADV
easat-261	32	37	.	.	PUNCT
easat-261	33	1	at	at	ADP
easat-261	33	2	the	the	DET
easat-261	33	3	same	same	ADJ
easat-261	33	4	time	time	NOUN
easat-261	33	5	,	,	PUNCT
easat-261	33	6	the	the	DET
easat-261	33	7	complementary	complementary	ADJ
easat-261	33	8	fibrinolytic	fibrinolytic	ADJ
easat-261	33	9	properties	property	NOUN
easat-261	33	10	of	of	ADP
easat-261	33	11	tpa	tpa	PROPN
easat-261	33	12	and	and	CCONJ
easat-261	33	13	prouk	prouk	NOUN
easat-261	33	14	show	show	VERB
easat-261	33	15	that	that	SCONJ
easat-261	33	16	in	in	ADP
easat-261	33	17	biology	biology	NOUN
easat-261	33	18	they	they	PRON
easat-261	33	19	were	be	AUX
easat-261	33	20	intended	intend	VERB
easat-261	33	21	to	to	PART
easat-261	33	22	function	function	VERB
easat-261	33	23	in	in	ADP
easat-261	33	24	combination	combination	NOUN
easat-261	33	25	.	.	PUNCT
easat-261	34	1	when	when	SCONJ
easat-261	34	2	used	use	VERB
easat-261	34	3	alone	alone	ADV
easat-261	34	4	to	to	PART
easat-261	34	5	dissolve	dissolve	VERB
easat-261	34	6	a	a	DET
easat-261	34	7	clot	clot	NOUN
easat-261	34	8	they	they	PRON
easat-261	34	9	are	be	AUX
easat-261	34	10	inefficient	inefficient	ADJ
easat-261	34	11	and	and	CCONJ
easat-261	34	12	requiring	require	VERB
easat-261	34	13	high	high	ADJ
easat-261	34	14	,	,	PUNCT
easat-261	34	15	non	non	ADJ
easat-261	34	16	-	-	ADJ
easat-261	34	17	specific	specific	ADJ
easat-261	34	18	doses	dose	NOUN
easat-261	34	19	,	,	PUNCT
easat-261	34	20	whereas	whereas	SCONJ
easat-261	34	21	in	in	ADP
easat-261	34	22	combination	combination	NOUN
easat-261	34	23	low	low	ADJ
easat-261	34	24	,	,	PUNCT
easat-261	34	25	fibrin	fibrin	NOUN
easat-261	34	26	-	-	PUNCT
easat-261	34	27	specific	specific	ADJ
easat-261	34	28	doses	dose	NOUN
easat-261	34	29	can	can	AUX
easat-261	34	30	be	be	AUX
easat-261	34	31	used	use	VERB
easat-261	34	32	since	since	SCONJ
easat-261	34	33	their	their	PRON
easat-261	34	34	combined	combine	VERB
easat-261	34	35	effects	effect	NOUN
easat-261	34	36	are	be	AUX
easat-261	34	37	synergistic	synergistic	ADJ
easat-261	34	38	.	.	PUNCT
easat-261	35	1	for	for	ADP
easat-261	35	2	example	example	NOUN
easat-261	35	3	,	,	PUNCT
easat-261	35	4	small	small	ADJ
easat-261	35	5	doses	dose	NOUN
easat-261	35	6	of	of	ADP
easat-261	35	7	tpa	tpa	PROPN
easat-261	35	8	and	and	CCONJ
easat-261	35	9	prouk	prouk	VERB
easat-261	35	10	that	that	PRON
easat-261	35	11	induce	induce	VERB
easat-261	35	12	25	25	NUM
easat-261	35	13	%	%	NOUN
easat-261	35	14	clot	clot	NOUN
easat-261	35	15	lysis	lysis	NOUN
easat-261	35	16	by	by	ADP
easat-261	35	17	each	each	DET
easat-261	35	18	alone	alone	ADV
easat-261	35	19	,	,	PUNCT
easat-261	35	20	induce	induce	VERB
easat-261	35	21	100	100	NUM
easat-261	35	22	%	%	NOUN
easat-261	35	23	lysis	lysis	NOUN
easat-261	35	24	when	when	SCONJ
easat-261	35	25	they	they	PRON
easat-261	35	26	are	be	AUX
easat-261	35	27	combined	combine	VERB
easat-261	35	28	(	(	PUNCT
easat-261	35	29	figure	figure	NOUN
easat-261	35	30	1	1	NUM
easat-261	35	31	)	)	PUNCT
easat-261	35	32	.	.	PUNCT
easat-261	36	1	a	a	DET
easat-261	36	2	similar	similar	ADJ
easat-261	36	3	lowdose	lowdose	ADJ
easat-261	36	4	combination	combination	NOUN
easat-261	36	5	was	be	AUX
easat-261	36	6	tested	test	VERB
easat-261	36	7	clinically	clinically	ADV
easat-261	36	8	in	in	ADP
easat-261	36	9	101	101	NUM
easat-261	36	10	patients	patient	NOUN
easat-261	36	11	with	with	ADP
easat-261	36	12	ami	ami	NOUN
easat-261	36	13	who	who	PRON
easat-261	36	14	were	be	AUX
easat-261	36	15	given	give	VERB
easat-261	36	16	a	a	DET
easat-261	36	17	5	5	NUM
easat-261	36	18	mg	mg	PROPN
easat-261	36	19	bolus	bolus	PROPN
easat-261	36	20	dose	dose	PROPN
easat-261	36	21	of	of	ADP
easat-261	36	22	tpa	tpa	PROPN
easat-261	36	23	followed	follow	VERB
easat-261	36	24	by	by	ADP
easat-261	36	25	an	an	DET
easat-261	36	26	mailto:vgurewich@tsillc.net	mailto:vgurewich@tsillc.net	PROPN
easat-261	36	27	19	19	NUM
easat-261	36	28	edelweiss	edelweiss	PROPN
easat-261	36	29	applied	apply	VERB
easat-261	36	30	science	science	NOUN
easat-261	36	31	and	and	CCONJ
easat-261	36	32	technology	technology	NOUN
easat-261	36	33	issn	issn	PROPN
easat-261	36	34	:	:	PUNCT
easat-261	36	35	2576	2576	NUM
easat-261	36	36	-	-	SYM
easat-261	36	37	8484	8484	NUM
easat-261	36	38	vol	vol	NOUN
easat-261	36	39	.	.	PROPN
easat-261	37	1	3	3	NUM
easat-261	37	2	,	,	PUNCT
easat-261	37	3	no	no	INTJ
easat-261	37	4	.	.	NOUN
easat-261	37	5	1	1	NUM
easat-261	37	6	:	:	SYM
easat-261	37	7	18	18	NUM
easat-261	37	8	-	-	SYM
easat-261	37	9	19	19	NUM
easat-261	37	10	,	,	PUNCT
easat-261	37	11	2019	2019	NUM
easat-261	37	12	doi	doi	NOUN
easat-261	37	13	:	:	PUNCT
easat-261	37	14	10.33805/2576.8484.162	10.33805/2576.8484.162	PROPN
easat-261	38	1	©	©	PROPN
easat-261	38	2	2019	2019	NUM
easat-261	38	3	by	by	ADP
easat-261	38	4	the	the	DET
easat-261	38	5	author	author	NOUN
easat-261	38	6	infusion	infusion	NOUN
easat-261	38	7	of	of	ADP
easat-261	38	8	40	40	NUM
easat-261	38	9	mg	mg	NOUN
easat-261	38	10	/	/	SYM
easat-261	38	11	h	h	NOUN
easat-261	38	12	of	of	ADP
easat-261	38	13	prouk	prouk	NOUN
easat-261	38	14	for	for	ADP
easat-261	38	15	90	90	NUM
easat-261	38	16	min	min	NOUN
easat-261	38	17	.	.	PUNCT
easat-261	39	1	the	the	DET
easat-261	39	2	coronary	coronary	ADJ
easat-261	39	3	vessel	vessel	NOUN
easat-261	39	4	responsible	responsible	ADJ
easat-261	39	5	for	for	ADP
easat-261	39	6	the	the	DET
easat-261	39	7	attack	attack	NOUN
easat-261	39	8	was	be	AUX
easat-261	39	9	opened	open	VERB
easat-261	39	10	in	in	ADP
easat-261	39	11	82	82	NUM
easat-261	39	12	%	%	NOUN
easat-261	39	13	of	of	ADP
easat-261	39	14	the	the	DET
easat-261	39	15	patients	patient	NOUN
easat-261	39	16	,	,	PUNCT
easat-261	39	17	and	and	CCONJ
easat-261	39	18	there	there	PRON
easat-261	39	19	was	be	VERB
easat-261	39	20	only	only	ADV
easat-261	39	21	one	one	NUM
easat-261	39	22	death	death	NOUN
easat-261	39	23	and	and	CCONJ
easat-261	39	24	no	no	DET
easat-261	39	25	bleeding	bleed	VERB
easat-261	39	26	complications	complication	NOUN
easat-261	39	27	[	[	X
easat-261	39	28	5	5	NUM
easat-261	39	29	]	]	PUNCT
easat-261	39	30	(	(	PUNCT
easat-261	39	31	figure	figure	NOUN
easat-261	39	32	2	2	NUM
easat-261	39	33	)	)	PUNCT
easat-261	39	34	.	.	PUNCT
easat-261	40	1	these	these	DET
easat-261	40	2	unprecedented	unprecedented	ADJ
easat-261	40	3	results	result	NOUN
easat-261	40	4	are	be	AUX
easat-261	40	5	a	a	DET
easat-261	40	6	substantial	substantial	ADJ
easat-261	40	7	improvement	improvement	NOUN
easat-261	40	8	over	over	ADP
easat-261	40	9	gusto	gusto	NOUN
easat-261	40	10	,	,	PUNCT
easat-261	40	11	the	the	DET
easat-261	40	12	best	good	ADJ
easat-261	40	13	of	of	ADP
easat-261	40	14	the	the	DET
easat-261	40	15	tpa	tpa	PROPN
easat-261	40	16	trials	trial	NOUN
easat-261	40	17	,	,	PUNCT
easat-261	40	18	in	in	ADP
easat-261	40	19	which	which	PRON
easat-261	40	20	the	the	DET
easat-261	40	21	coronary	coronary	ADJ
easat-261	40	22	responsible	responsible	ADJ
easat-261	40	23	for	for	ADP
easat-261	40	24	the	the	DET
easat-261	40	25	ami	ami	NOUN
easat-261	40	26	was	be	AUX
easat-261	40	27	opened	open	VERB
easat-261	40	28	in	in	ADP
easat-261	40	29	only	only	ADV
easat-261	40	30	45	45	NUM
easat-261	40	31	%	%	NOUN
easat-261	40	32	of	of	ADP
easat-261	40	33	patients	patient	NOUN
easat-261	40	34	,	,	PUNCT
easat-261	40	35	and	and	CCONJ
easat-261	40	36	deaths	death	NOUN
easat-261	40	37	were	be	AUX
easat-261	40	38	6.3	6.3	NUM
easat-261	40	39	%	%	NOUN
easat-261	40	40	.	.	PUNCT
easat-261	41	1	these	these	DET
easat-261	41	2	results	result	NOUN
easat-261	41	3	represent	represent	VERB
easat-261	41	4	a	a	DET
easat-261	41	5	clinical	clinical	ADJ
easat-261	41	6	verification	verification	NOUN
easat-261	41	7	of	of	ADP
easat-261	41	8	in	in	ADP
easat-261	41	9	vitro	vitro	X
easat-261	41	10	studies	study	NOUN
easat-261	41	11	tpa	tpa	PROPN
easat-261	41	12	and	and	CCONJ
easat-261	41	13	prouk	prouk	VERB
easat-261	41	14	and	and	CCONJ
easat-261	41	15	show	show	VERB
easat-261	41	16	that	that	SCONJ
easat-261	41	17	effective	effective	ADJ
easat-261	41	18	and	and	CCONJ
easat-261	41	19	safe	safe	ADJ
easat-261	41	20	fibrinolysis	fibrinolysis	NOUN
easat-261	41	21	requires	require	VERB
easat-261	41	22	both	both	PRON
easat-261	41	23	of	of	ADP
easat-261	41	24	these	these	DET
easat-261	41	25	natural	natural	ADJ
easat-261	41	26	plasminogen	plasminogen	NOUN
easat-261	41	27	activators	activator	NOUN
easat-261	41	28	in	in	ADP
easat-261	41	29	a	a	DET
easat-261	41	30	sequential	sequential	ADJ
easat-261	41	31	combination	combination	NOUN
easat-261	41	32	,	,	PUNCT
easat-261	41	33	and	and	CCONJ
easat-261	41	34	that	that	SCONJ
easat-261	41	35	monotherapy	monotherapy	NOUN
easat-261	41	36	with	with	ADP
easat-261	41	37	tpa	tpa	PROPN
easat-261	41	38	alone	alone	ADV
easat-261	41	39	has	have	AUX
easat-261	41	40	been	be	AUX
easat-261	41	41	an	an	DET
easat-261	41	42	unfortunate	unfortunate	ADJ
easat-261	41	43	mistake	mistake	NOUN
easat-261	41	44	.	.	PUNCT
easat-261	42	1	single	single	ADJ
easat-261	42	2	activator	activator	NOUN
easat-261	42	3	and	and	CCONJ
easat-261	42	4	combination	combination	NOUN
easat-261	42	5	in	in	ADP
easat-261	42	6	clot	clot	NOUN
easat-261	42	7	lysis	lysis	NOUN
easat-261	42	8	(	(	PUNCT
easat-261	42	9	left	leave	VERB
easat-261	42	10	)	)	PUNCT
easat-261	42	11	and	and	CCONJ
easat-261	42	12	in	in	ADP
easat-261	42	13	clinical	clinical	ADJ
easat-261	42	14	trials	trial	NOUN
easat-261	42	15	(	(	PUNCT
easat-261	42	16	right	right	ADJ
easat-261	42	17	)	)	PUNCT
easat-261	42	18	figure	figure	NOUN
easat-261	42	19	1	1	NUM
easat-261	42	20	.	.	PUNCT
easat-261	43	1	lysis	lysis	NOUN
easat-261	43	2	by	by	ADP
easat-261	43	3	tpa	tpa	PROPN
easat-261	43	4	/	/	SYM
easat-261	43	5	upa	upa	NOUN
easat-261	43	6	alone	alone	ADJ
easat-261	43	7	or	or	CCONJ
easat-261	43	8	in	in	ADP
easat-261	43	9	combination	combination	NOUN
easat-261	43	10	.	.	PUNCT
easat-261	44	1	figure	figure	NOUN
easat-261	44	2	2	2	NUM
easat-261	44	3	.	.	PUNCT
easat-261	44	4	clinical	clinical	ADJ
easat-261	44	5	trial	trial	NOUN
easat-261	44	6	of	of	ADP
easat-261	44	7	combination	combination	NOUN
easat-261	44	8	in	in	ADP
easat-261	44	9	heart	heart	NOUN
easat-261	44	10	attack	attack	NOUN
easat-261	44	11	.	.	PUNCT
easat-261	45	1	patent	patent	NOUN
easat-261	45	2	trial	trial	NOUN
easat-261	45	3	of	of	ADP
easat-261	45	4	sequential	sequential	ADJ
easat-261	45	5	combination	combination	NOUN
easat-261	45	6	(	(	PUNCT
easat-261	45	7	green	green	NOUN
easat-261	45	8	)	)	PUNCT
easat-261	45	9	vs	vs	ADP
easat-261	45	10	gusto	gusto	ADJ
easat-261	45	11	trial	trial	NOUN
easat-261	45	12	of	of	ADP
easat-261	45	13	tpa	tpa	PROPN
easat-261	45	14	mono	mono	PROPN
easat-261	45	15	therapy	therapy	NOUN
easat-261	45	16	(	(	PUNCT
easat-261	45	17	red	red	ADJ
easat-261	45	18	)	)	PUNCT
easat-261	45	19	.	.	PUNCT
easat-261	46	1	abbreviations	abbreviation	NOUN
easat-261	46	2	:	:	PUNCT
easat-261	46	3	tpa	tpa	NOUN
easat-261	46	4	-	-	PUNCT
easat-261	46	5	tissue	tissue	NOUN
easat-261	46	6	plasminogen	plasminogen	NOUN
easat-261	46	7	activator	activator	NOUN
easat-261	46	8	,	,	PUNCT
easat-261	46	9	sk	sk	NOUN
easat-261	46	10	-	-	PUNCT
easat-261	46	11	streptokinase	streptokinase	NOUN
easat-261	46	12	,	,	PUNCT
easat-261	46	13	pci	pci	ADJ
easat-261	46	14	-	-	PUNCT
easat-261	46	15	percutaneous	percutaneous	ADJ
easat-261	46	16	coronary	coronary	ADJ
easat-261	46	17	intervention	intervention	NOUN
easat-261	46	18	,	,	PUNCT
easat-261	46	19	upaurokinase	upaurokinase	ADJ
easat-261	46	20	plasminogen	plasminogen	NOUN
easat-261	46	21	activator	activator	NOUN
easat-261	46	22	,	,	PUNCT
easat-261	46	23	prouk	prouk	NOUN
easat-261	46	24	-	-	PUNCT
easat-261	46	25	prourokinase	prourokinase	NOUN
easat-261	46	26	.	.	PUNCT
easat-261	47	1	references	reference	NOUN
easat-261	47	2	[	[	X
easat-261	47	3	1	1	X
easat-261	47	4	]	]	PUNCT
easat-261	47	5	j.	j.	PROPN
easat-261	47	6	m.	m.	PROPN
easat-261	47	7	brophy	brophy	PROPN
easat-261	47	8	and	and	CCONJ
easat-261	47	9	l.	l.	PROPN
easat-261	47	10	joseph	joseph	PROPN
easat-261	47	11	,	,	PUNCT
easat-261	47	12	"	"	PUNCT
easat-261	47	13	placing	place	VERB
easat-261	47	14	trials	trial	NOUN
easat-261	47	15	in	in	ADP
easat-261	47	16	context	context	NOUN
easat-261	47	17	using	use	VERB
easat-261	47	18	bayesian	bayesian	NOUN
easat-261	47	19	analysis	analysis	NOUN
easat-261	47	20	:	:	PUNCT
easat-261	47	21	gusto	gusto	NOUN
easat-261	47	22	revisited	revisit	VERB
easat-261	47	23	by	by	ADP
easat-261	47	24	reverend	reverend	PROPN
easat-261	47	25	bayes	bayes	PROPN
easat-261	47	26	,	,	PUNCT
easat-261	47	27	"	"	PUNCT
easat-261	47	28	jama	jama	NOUN
easat-261	47	29	,	,	PUNCT
easat-261	47	30	vol	vol	NOUN
easat-261	47	31	.	.	PROPN
easat-261	47	32	273	273	NUM
easat-261	47	33	,	,	PUNCT
easat-261	47	34	no	no	INTJ
easat-261	47	35	.	.	NOUN
easat-261	47	36	11	11	NUM
easat-261	47	37	,	,	PUNCT
easat-261	47	38	pp	pp	ADJ
easat-261	47	39	.	.	PUNCT
easat-261	48	1	871	871	NUM
easat-261	48	2	-	-	SYM
easat-261	48	3	875	875	NUM
easat-261	48	4	,	,	PUNCT
easat-261	48	5	1995	1995	NUM
easat-261	48	6	.	.	PUNCT
easat-261	49	1	https://doi.org/10.1001/jama.1995.03520350053028	https://doi.org/10.1001/jama.1995.03520350053028	PROPN
easat-261	50	1	[	[	X
easat-261	50	2	2	2	NUM
easat-261	50	3	]	]	PUNCT
easat-261	50	4	i.-c	i.-c	NOUN
easat-261	50	5	.	.	PUNCT
easat-261	51	1	group	group	NOUN
easat-261	51	2	,	,	PUNCT
easat-261	51	3	"	"	PUNCT
easat-261	51	4	the	the	DET
easat-261	51	5	benefits	benefit	NOUN
easat-261	51	6	and	and	CCONJ
easat-261	51	7	harms	harm	NOUN
easat-261	51	8	of	of	ADP
easat-261	51	9	intravenous	intravenous	ADJ
easat-261	51	10	thrombolysis	thrombolysis	NOUN
easat-261	51	11	with	with	ADP
easat-261	51	12	recombinant	recombinant	ADJ
easat-261	51	13	tissue	tissue	NOUN
easat-261	51	14	plasminogen	plasminogen	NOUN
easat-261	51	15	activator	activator	NOUN
easat-261	51	16	within	within	ADP
easat-261	51	17	6	6	NUM
easat-261	51	18	h	h	NOUN
easat-261	51	19	of	of	ADP
easat-261	51	20	acute	acute	ADJ
easat-261	51	21	ischaemic	ischaemic	ADJ
easat-261	51	22	stroke	stroke	NOUN
easat-261	51	23	(	(	PUNCT
easat-261	51	24	the	the	DET
easat-261	51	25	third	third	ADJ
easat-261	51	26	international	international	ADJ
easat-261	51	27	stroke	stroke	NOUN
easat-261	51	28	trial	trial	NOUN
easat-261	51	29	[	[	X
easat-261	51	30	ist-3	ist-3	SYM
easat-261	51	31	]	]	X
easat-261	51	32	):	):	PUNCT
easat-261	51	33	a	a	DET
easat-261	51	34	randomised	randomised	ADJ
easat-261	51	35	controlled	control	VERB
easat-261	51	36	trial	trial	NOUN
easat-261	51	37	,	,	PUNCT
easat-261	51	38	"	"	PUNCT
easat-261	51	39	the	the	DET
easat-261	51	40	lancet	lancet	NOUN
easat-261	51	41	,	,	PUNCT
easat-261	51	42	vol	vol	NOUN
easat-261	51	43	.	.	PROPN
easat-261	51	44	379	379	NUM
easat-261	51	45	,	,	PUNCT
easat-261	51	46	no	no	INTJ
easat-261	51	47	.	.	NOUN
easat-261	51	48	9834	9834	NUM
easat-261	51	49	,	,	PUNCT
easat-261	51	50	pp	pp	ADV
easat-261	51	51	.	.	PUNCT
easat-261	51	52	2352	2352	NUM
easat-261	51	53	-	-	SYM
easat-261	51	54	2363	2363	NUM
easat-261	51	55	,	,	PUNCT
easat-261	51	56	2012	2012	NUM
easat-261	51	57	.	.	PUNCT
easat-261	52	1	[	[	X
easat-261	52	2	3	3	X
easat-261	52	3	]	]	X
easat-261	52	4	r.	r.	NOUN
easat-261	52	5	pannell	pannell	PROPN
easat-261	52	6	,	,	PUNCT
easat-261	52	7	s.	s.	PROPN
easat-261	52	8	li	li	PROPN
easat-261	52	9	,	,	PUNCT
easat-261	52	10	and	and	CCONJ
easat-261	52	11	v.	v.	ADP
easat-261	52	12	gurewich	gurewich	NOUN
easat-261	52	13	,	,	PUNCT
easat-261	52	14	"	"	PUNCT
easat-261	52	15	highly	highly	ADV
easat-261	52	16	effective	effective	ADJ
easat-261	52	17	fibrinolysis	fibrinolysis	NOUN
easat-261	52	18	by	by	ADP
easat-261	52	19	a	a	DET
easat-261	52	20	sequential	sequential	ADJ
easat-261	52	21	,	,	PUNCT
easat-261	52	22	synergistic	synergistic	ADJ
easat-261	52	23	combination	combination	NOUN
easat-261	52	24	of	of	ADP
easat-261	52	25	mini	mini	NOUN
easat-261	52	26	-	-	ADJ
easat-261	52	27	dose	dose	ADJ
easat-261	52	28	tpa	tpa	PROPN
easat-261	52	29	plus	plus	CCONJ
easat-261	52	30	low	low	ADJ
easat-261	52	31	dose	dose	NOUN
easat-261	52	32	prouk	prouk	NOUN
easat-261	52	33	,	,	PUNCT
easat-261	52	34	"	"	PUNCT
easat-261	52	35	plos	plos	PROPN
easat-261	52	36	one	one	NUM
easat-261	52	37	,	,	PUNCT
easat-261	52	38	vol	vol	NOUN
easat-261	52	39	.	.	PROPN
easat-261	52	40	10	10	NUM
easat-261	52	41	,	,	PUNCT
easat-261	52	42	pp	pp	ADJ
easat-261	52	43	.	.	PUNCT
easat-261	53	1	1	1	NUM
easat-261	53	2	-	-	SYM
easat-261	53	3	15	15	NUM
easat-261	53	4	,	,	PUNCT
easat-261	53	5	2015	2015	NUM
easat-261	53	6	.	.	PUNCT
easat-261	54	1	https://doi.org/10.1371/journal.pone.0122018	https://doi.org/10.1371/journal.pone.0122018	VERB
easat-261	55	1	[	[	X
easat-261	55	2	4	4	X
easat-261	55	3	]	]	X
easat-261	55	4	d.	d.	PROPN
easat-261	55	5	c.	c.	PROPN
easat-261	55	6	rijken	rijken	PROPN
easat-261	55	7	,	,	PUNCT
easat-261	55	8	m.	m.	NOUN
easat-261	55	9	hoylaerts	hoylaert	NOUN
easat-261	55	10	,	,	PUNCT
easat-261	55	11	and	and	CCONJ
easat-261	55	12	d.	d.	PROPN
easat-261	55	13	collen	collen	PROPN
easat-261	55	14	,	,	PUNCT
easat-261	55	15	"	"	PUNCT
easat-261	55	16	fibrinolytic	fibrinolytic	ADJ
easat-261	55	17	properties	property	NOUN
easat-261	55	18	of	of	ADP
easat-261	55	19	one	one	NUM
easat-261	55	20	-	-	PUNCT
easat-261	55	21	chain	chain	NOUN
easat-261	55	22	and	and	CCONJ
easat-261	55	23	two	two	NUM
easat-261	55	24	-	-	PUNCT
easat-261	55	25	chain	chain	NOUN
easat-261	55	26	human	human	ADJ
easat-261	55	27	extrinsic	extrinsic	ADJ
easat-261	55	28	(	(	PUNCT
easat-261	55	29	tissue	tissue	NOUN
easat-261	55	30	-	-	PUNCT
easat-261	55	31	type	type	NOUN
easat-261	55	32	)	)	PUNCT
easat-261	55	33	plasminogen	plasminogen	NOUN
easat-261	55	34	activator	activator	NOUN
easat-261	55	35	,	,	PUNCT
easat-261	55	36	"	"	PUNCT
easat-261	55	37	journal	journal	NOUN
easat-261	55	38	of	of	ADP
easat-261	55	39	biological	biological	ADJ
easat-261	55	40	chemistry	chemistry	NOUN
easat-261	55	41	,	,	PUNCT
easat-261	55	42	vol	vol	NOUN
easat-261	55	43	.	.	PROPN
easat-261	56	1	257	257	NUM
easat-261	56	2	,	,	PUNCT
easat-261	56	3	no	no	INTJ
easat-261	56	4	.	.	NOUN
easat-261	56	5	6	6	NUM
easat-261	56	6	,	,	PUNCT
easat-261	56	7	pp	pp	ADJ
easat-261	56	8	.	.	PUNCT
easat-261	57	1	2920	2920	NUM
easat-261	57	2	-	-	SYM
easat-261	57	3	2925	2925	NUM
easat-261	57	4	,	,	PUNCT
easat-261	57	5	1982	1982	NUM
easat-261	57	6	.	.	PUNCT
easat-261	58	1	https://doi.org/10.1016/s0021-9258(19)81052-9	https://doi.org/10.1016/s0021-9258(19)81052-9	NOUN
easat-261	59	1	[	[	X
easat-261	59	2	5	5	X
easat-261	59	3	]	]	PUNCT
easat-261	59	4	v.	v.	ADP
easat-261	59	5	gurewich	gurewich	NOUN
easat-261	59	6	,	,	PUNCT
easat-261	59	7	m.	m.	NOUN
easat-261	59	8	johnstone	johnstone	PROPN
easat-261	59	9	,	,	PUNCT
easat-261	59	10	j.-p	j.-p	PROPN
easat-261	59	11	.	.	PUNCT
easat-261	60	1	loza	loza	PROPN
easat-261	60	2	,	,	PUNCT
easat-261	60	3	and	and	CCONJ
easat-261	60	4	r.	r.	PROPN
easat-261	60	5	pannell	pannell	NOUN
easat-261	60	6	,	,	PUNCT
easat-261	60	7	"	"	PUNCT
easat-261	60	8	pro‐urokinase	pro‐urokinase	NOUN
easat-261	60	9	and	and	CCONJ
easat-261	60	10	prekallikrein	prekallikrein	NOUN
easat-261	60	11	are	be	AUX
easat-261	60	12	both	both	PRON
easat-261	60	13	associated	associate	VERB
easat-261	60	14	with	with	ADP
easat-261	60	15	platelets	platelet	NOUN
easat-261	60	16	:	:	PUNCT
easat-261	60	17	implications	implication	NOUN
easat-261	60	18	for	for	ADP
easat-261	60	19	the	the	DET
easat-261	60	20	intrinsic	intrinsic	ADJ
easat-261	60	21	pathway	pathway	NOUN
easat-261	60	22	of	of	ADP
easat-261	60	23	fibrinolysis	fibrinolysis	NOUN
easat-261	60	24	and	and	CCONJ
easat-261	60	25	for	for	ADP
easat-261	60	26	therapeutic	therapeutic	ADJ
easat-261	60	27	thrombolysis	thrombolysis	NOUN
easat-261	60	28	,	,	PUNCT
easat-261	60	29	"	"	PUNCT
easat-261	60	30	febs	febs	NOUN
easat-261	60	31	letters	letter	NOUN
easat-261	60	32	,	,	PUNCT
easat-261	60	33	vol	vol	NOUN
easat-261	60	34	.	.	PROPN
easat-261	60	35	318	318	NUM
easat-261	60	36	,	,	PUNCT
easat-261	60	37	no	no	INTJ
easat-261	60	38	.	.	NOUN
easat-261	60	39	3	3	NUM
easat-261	60	40	,	,	PUNCT
easat-261	60	41	pp	pp	ADJ
easat-261	60	42	.	.	PUNCT
easat-261	61	1	317	317	NUM
easat-261	61	2	-	-	SYM
easat-261	61	3	321	321	NUM
easat-261	61	4	,	,	PUNCT
easat-261	61	5	1993	1993	NUM
easat-261	61	6	.	.	PUNCT
easat-261	62	1	https://doi.org/10.1016/0014-5793(93)80537-5	https://doi.org/10.1016/0014-5793(93)80537-5	PRON
easat-261	62	2	https://doi.org/10.1001/jama.1995.03520350053028	https://doi.org/10.1001/jama.1995.03520350053028	PROPN
easat-261	62	3	https://doi.org/10.1371/journal.pone.0122018	https://doi.org/10.1371/journal.pone.0122018	VERB
easat-261	62	4	https://doi.org/10.1016/s0021-9258(19)81052-9	https://doi.org/10.1016/s0021-9258(19)81052-9	NOUN
easat-261	62	5	https://doi.org/10.1016/0014-5793(93)80537-5	https://doi.org/10.1016/0014-5793(93)80537-5	X