id	sid	tid	token	lemma	pos
easat-2730	1	1	edelweiss	edelweiss	PROPN
easat-2730	1	2	applied	apply	VERB
easat-2730	1	3	science	science	NOUN
easat-2730	1	4	and	and	CCONJ
easat-2730	1	5	technology	technology	NOUN
easat-2730	1	6	issn	issn	PROPN
easat-2730	1	7	:	:	PUNCT
easat-2730	1	8	2576	2576	NUM
easat-2730	1	9	-	-	SYM
easat-2730	1	10	8484	8484	NUM
easat-2730	1	11	vol	vol	NOUN
easat-2730	1	12	.	.	PROPN
easat-2730	1	13	8	8	NUM
easat-2730	1	14	,	,	PUNCT
easat-2730	1	15	no	no	INTJ
easat-2730	1	16	.	.	NOUN
easat-2730	1	17	6	6	NUM
easat-2730	1	18	,	,	PUNCT
easat-2730	1	19	3441	3441	NUM
easat-2730	1	20	-	-	SYM
easat-2730	1	21	3456	3456	NUM
easat-2730	1	22	2024	2024	NUM
easat-2730	1	23	publisher	publisher	NOUN
easat-2730	1	24	:	:	PUNCT
easat-2730	1	25	learning	learn	VERB
easat-2730	1	26	gate	gate	NOUN
easat-2730	1	27	doi	doi	PROPN
easat-2730	1	28	:	:	PUNCT
easat-2730	1	29	10.55214/25768484.v8i6.2730	10.55214/25768484.v8i6.2730	NUM
easat-2730	1	30	©	©	ADP
easat-2730	1	31	2024	2024	NUM
easat-2730	1	32	by	by	ADP
easat-2730	1	33	the	the	DET
easat-2730	1	34	authors	author	NOUN
easat-2730	1	35	;	;	PUNCT
easat-2730	1	36	licensee	licensee	PROPN
easat-2730	1	37	learning	learning	NOUN
easat-2730	1	38	gate	gate	NOUN
easat-2730	1	39	©	©	PROPN
easat-2730	1	40	2024	2024	NUM
easat-2730	1	41	by	by	ADP
easat-2730	1	42	the	the	DET
easat-2730	1	43	authors	author	NOUN
easat-2730	1	44	;	;	PUNCT
easat-2730	1	45	licensee	licensee	PROPN
easat-2730	1	46	learning	learn	VERB
easat-2730	1	47	gate	gate	NOUN
easat-2730	1	48	*	*	PUNCT
easat-2730	1	49	correspondence	correspondence	NOUN
easat-2730	1	50	:	:	PUNCT
easat-2730	1	51	md_sabariah@upm.edu.my	md_sabariah@upm.edu.my	NOUN
easat-2730	1	52	modulatory	modulatory	NOUN
easat-2730	1	53	potentials	potential	NOUN
easat-2730	1	54	of	of	ADP
easat-2730	1	55	nitric	nitric	ADJ
easat-2730	1	56	oxide	oxide	NOUN
easat-2730	1	57	in	in	ADP
easat-2730	1	58	obesity	obesity	NOUN
easat-2730	1	59	-	-	PUNCT
easat-2730	1	60	induced	induce	VERB
easat-2730	1	61	endothelial	endothelial	ADJ
easat-2730	1	62	dysfunction	dysfunction	NOUN
easat-2730	2	1	ibrahim	ibrahim	PROPN
easat-2730	2	2	kalle	kalle	PROPN
easat-2730	2	3	kwaifa1,2	kwaifa1,2	PROPN
easat-2730	2	4	,	,	PUNCT
easat-2730	2	5	sabariah	sabariah	PROPN
easat-2730	2	6	,	,	PUNCT
easat-2730	2	7	md	md	PROPN
easat-2730	2	8	noor1	noor1	PROPN
easat-2730	2	9	*	*	PROPN
easat-2730	2	10	1department	1department	NUM
easat-2730	2	11	of	of	ADP
easat-2730	2	12	pathology	pathology	NOUN
easat-2730	2	13	,	,	PUNCT
easat-2730	2	14	faculty	faculty	NOUN
easat-2730	2	15	of	of	ADP
easat-2730	2	16	medicine	medicine	NOUN
easat-2730	2	17	and	and	CCONJ
easat-2730	2	18	health	health	NOUN
easat-2730	2	19	sciences	sciences	PROPN
easat-2730	2	20	,	,	PUNCT
easat-2730	2	21	universiti	universiti	PROPN
easat-2730	2	22	putra	putra	PROPN
easat-2730	2	23	malaysia	malaysia	PROPN
easat-2730	2	24	(	(	PUNCT
easat-2730	2	25	upm	upm	PROPN
easat-2730	2	26	)	)	PUNCT
easat-2730	2	27	,	,	PUNCT
easat-2730	2	28	selangor	selangor	PROPN
easat-2730	2	29	,	,	PUNCT
easat-2730	2	30	43400	43400	NUM
easat-2730	2	31	,	,	PUNCT
easat-2730	2	32	malaysia	malaysia	NOUN
easat-2730	2	33	;	;	PUNCT
easat-2730	2	34	ibrahim.kwaifa@udusok.edu.ng	ibrahim.kwaifa@udusok.edu.ng	ADJ
easat-2730	2	35	(	(	PUNCT
easat-2730	2	36	i.k.k	i.k.k	ADJ
easat-2730	2	37	.	.	PUNCT
easat-2730	2	38	)	)	PUNCT
easat-2730	2	39	;	;	PUNCT
easat-2730	2	40	md_sabariah@upm.edu.my	md_sabariah@upm.edu.my	NOUN
easat-2730	2	41	(	(	PUNCT
easat-2730	2	42	s.m.n	s.m.n	ADJ
easat-2730	2	43	.	.	PUNCT
easat-2730	2	44	)	)	PUNCT
easat-2730	3	1	2department	2department	NUM
easat-2730	3	2	of	of	ADP
easat-2730	3	3	haematology	haematology	NOUN
easat-2730	3	4	,	,	PUNCT
easat-2730	3	5	school	school	NOUN
easat-2730	3	6	of	of	ADP
easat-2730	3	7	medical	medical	ADJ
easat-2730	3	8	laboratory	laboratory	NOUN
easat-2730	3	9	sciences	sciences	PROPN
easat-2730	3	10	,	,	PUNCT
easat-2730	3	11	college	college	NOUN
easat-2730	3	12	of	of	ADP
easat-2730	3	13	health	health	PROPN
easat-2730	3	14	sciences	sciences	PROPN
easat-2730	3	15	,	,	PUNCT
easat-2730	3	16	usmanu	usmanu	PROPN
easat-2730	3	17	danfodiyo	danfodiyo	PROPN
easat-2730	3	18	university	university	PROPN
easat-2730	3	19	(	(	PUNCT
easat-2730	3	20	udu	udu	PROPN
easat-2730	3	21	)	)	PUNCT
easat-2730	3	22	,	,	PUNCT
easat-2730	3	23	sokoto	sokoto	PROPN
easat-2730	3	24	,	,	PUNCT
easat-2730	3	25	north	north	NOUN
easat-2730	3	26	-	-	PUNCT
easat-2730	3	27	western	western	ADJ
easat-2730	3	28	,	,	PUNCT
easat-2730	3	29	2346	2346	NUM
easat-2730	3	30	,	,	PUNCT
easat-2730	3	31	nigeria	nigeria	PROPN
easat-2730	3	32	.	.	PUNCT
easat-2730	4	1	abstract	abstract	ADJ
easat-2730	4	2	:	:	PUNCT
easat-2730	4	3	obesity	obesity	NOUN
easat-2730	4	4	is	be	AUX
easat-2730	4	5	caused	cause	VERB
easat-2730	4	6	by	by	ADP
easat-2730	4	7	a	a	DET
easat-2730	4	8	significant	significant	ADJ
easat-2730	4	9	increase	increase	NOUN
easat-2730	4	10	in	in	ADP
easat-2730	4	11	adipose	adipose	ADJ
easat-2730	4	12	tissue	tissue	NOUN
easat-2730	4	13	due	due	ADP
easat-2730	4	14	to	to	ADP
easat-2730	4	15	excessive	excessive	ADJ
easat-2730	4	16	caloric	caloric	PROPN
easat-2730	4	17	intake	intake	NOUN
easat-2730	4	18	that	that	PRON
easat-2730	4	19	exceeds	exceed	VERB
easat-2730	4	20	energy	energy	NOUN
easat-2730	4	21	expenditure	expenditure	NOUN
easat-2730	4	22	.	.	PUNCT
easat-2730	5	1	obesity	obesity	NOUN
easat-2730	5	2	has	have	AUX
easat-2730	5	3	emerged	emerge	VERB
easat-2730	5	4	as	as	ADP
easat-2730	5	5	a	a	DET
easat-2730	5	6	significant	significant	ADJ
easat-2730	5	7	public	public	ADJ
easat-2730	5	8	health	health	NOUN
easat-2730	5	9	issue	issue	NOUN
easat-2730	5	10	in	in	ADP
easat-2730	5	11	both	both	CCONJ
easat-2730	5	12	poor	poor	ADJ
easat-2730	5	13	resource	resource	NOUN
easat-2730	5	14	and	and	CCONJ
easat-2730	5	15	economic	economic	ADJ
easat-2730	5	16	developed	develop	VERB
easat-2730	5	17	nations	nation	NOUN
easat-2730	5	18	,	,	PUNCT
easat-2730	5	19	owing	owe	VERB
easat-2730	5	20	to	to	ADP
easat-2730	5	21	its	its	PRON
easat-2730	5	22	increased	increase	VERB
easat-2730	5	23	incidence	incidence	NOUN
easat-2730	5	24	and	and	CCONJ
easat-2730	5	25	links	link	NOUN
easat-2730	5	26	to	to	ADP
easat-2730	5	27	chronic	chronic	ADJ
easat-2730	5	28	diseases	disease	NOUN
easat-2730	5	29	,	,	PUNCT
easat-2730	5	30	such	such	ADJ
easat-2730	5	31	osteoarthritis	osteoarthritis	NOUN
easat-2730	5	32	,	,	PUNCT
easat-2730	5	33	hypertension	hypertension	NOUN
easat-2730	5	34	,	,	PUNCT
easat-2730	5	35	non	non	ADJ
easat-2730	5	36	-	-	ADJ
easat-2730	5	37	alcoholic	alcoholic	ADJ
easat-2730	5	38	fatty	fatty	NOUN
easat-2730	5	39	liver	liver	NOUN
easat-2730	5	40	disease	disease	NOUN
easat-2730	5	41	(	(	PUNCT
easat-2730	5	42	nafld	nafld	ADV
easat-2730	5	43	)	)	PUNCT
easat-2730	5	44	,	,	PUNCT
easat-2730	5	45	and	and	CCONJ
easat-2730	5	46	cardiovascular	cardiovascular	ADJ
easat-2730	5	47	diseases	disease	NOUN
easat-2730	5	48	(	(	PUNCT
easat-2730	5	49	cvds	cvds	PROPN
easat-2730	5	50	)	)	PUNCT
easat-2730	5	51	.	.	PUNCT
easat-2730	6	1	it	it	PRON
easat-2730	6	2	is	be	AUX
easat-2730	6	3	believed	believe	VERB
easat-2730	6	4	that	that	SCONJ
easat-2730	6	5	uncoupled	uncoupled	ADJ
easat-2730	6	6	enos	eno	NOUN
easat-2730	6	7	,	,	PUNCT
easat-2730	6	8	nicotinamide	nicotinamide	NOUN
easat-2730	6	9	adenine	adenine	ADJ
easat-2730	6	10	dinucleotide	dinucleotide	NOUN
easat-2730	6	11	phosphate	phosphate	NOUN
easat-2730	6	12	(	(	PUNCT
easat-2730	6	13	nadph	nadph	ADJ
easat-2730	6	14	)	)	PUNCT
easat-2730	6	15	oxidases	oxidase	NOUN
easat-2730	6	16	,	,	PUNCT
easat-2730	6	17	xanthine	xanthine	NOUN
easat-2730	6	18	oxidase	oxidase	PROPN
easat-2730	6	19	,	,	PUNCT
easat-2730	6	20	lipoxygenase	lipoxygenase	NOUN
easat-2730	6	21	,	,	PUNCT
easat-2730	6	22	cyclooxygenase	cyclooxygenase	NOUN
easat-2730	6	23	,	,	PUNCT
easat-2730	6	24	microsomal	microsomal	ADJ
easat-2730	6	25	p-450	p-450	NOUN
easat-2730	6	26	enzymes	enzyme	NOUN
easat-2730	6	27	,	,	PUNCT
easat-2730	6	28	and	and	CCONJ
easat-2730	6	29	pro	pro	ADJ
easat-2730	6	30	-	-	ADJ
easat-2730	6	31	oxidant	oxidant	ADJ
easat-2730	6	32	heme	heme	NOUN
easat-2730	6	33	molecules	molecule	NOUN
easat-2730	6	34	are	be	AUX
easat-2730	6	35	responsible	responsible	ADJ
easat-2730	6	36	for	for	ADP
easat-2730	6	37	the	the	DET
easat-2730	6	38	drastic	drastic	ADJ
easat-2730	6	39	decrease	decrease	NOUN
easat-2730	6	40	in	in	ADP
easat-2730	6	41	no	no	DET
easat-2730	6	42	production	production	NOUN
easat-2730	6	43	and	and	CCONJ
easat-2730	6	44	the	the	DET
easat-2730	6	45	relative	relative	ADJ
easat-2730	6	46	increase	increase	NOUN
easat-2730	6	47	in	in	ADP
easat-2730	6	48	reactive	reactive	ADJ
easat-2730	6	49	oxygen	oxygen	NOUN
easat-2730	6	50	species	specie	NOUN
easat-2730	6	51	(	(	PUNCT
easat-2730	6	52	ros	ros	PROPN
easat-2730	6	53	)	)	PUNCT
easat-2730	6	54	secretion	secretion	NOUN
easat-2730	6	55	,	,	PUNCT
easat-2730	6	56	which	which	PRON
easat-2730	6	57	are	be	AUX
easat-2730	6	58	considered	consider	VERB
easat-2730	6	59	as	as	ADP
easat-2730	6	60	the	the	DET
easat-2730	6	61	molecular	molecular	ADJ
easat-2730	6	62	mechanisms	mechanism	NOUN
easat-2730	6	63	associated	associate	VERB
easat-2730	6	64	with	with	ADP
easat-2730	6	65	obesity	obesity	NOUN
easat-2730	6	66	-	-	PUNCT
easat-2730	6	67	induced	induce	VERB
easat-2730	6	68	endothelial	endothelial	ADJ
easat-2730	6	69	dysfunction	dysfunction	NOUN
easat-2730	6	70	.	.	PUNCT
easat-2730	7	1	vascular	vascular	ADJ
easat-2730	7	2	endothelium	endothelium	NOUN
easat-2730	7	3	defines	define	VERB
easat-2730	7	4	a	a	DET
easat-2730	7	5	monolayer	monolayer	NOUN
easat-2730	7	6	of	of	ADP
easat-2730	7	7	cells	cell	NOUN
easat-2730	7	8	,	,	PUNCT
easat-2730	7	9	which	which	PRON
easat-2730	7	10	lies	lie	VERB
easat-2730	7	11	between	between	ADP
easat-2730	7	12	the	the	DET
easat-2730	7	13	vascular	vascular	ADJ
easat-2730	7	14	smooth	smooth	ADJ
easat-2730	7	15	muscle	muscle	NOUN
easat-2730	7	16	cells	cell	NOUN
easat-2730	7	17	(	(	PUNCT
easat-2730	7	18	vsmcs	vsmcs	ADJ
easat-2730	7	19	)	)	PUNCT
easat-2730	7	20	and	and	CCONJ
easat-2730	7	21	the	the	DET
easat-2730	7	22	vessel	vessel	NOUN
easat-2730	7	23	lumen	luman	NOUN
easat-2730	7	24	.	.	PUNCT
easat-2730	8	1	it	it	PRON
easat-2730	8	2	performs	perform	VERB
easat-2730	8	3	a	a	DET
easat-2730	8	4	number	number	NOUN
easat-2730	8	5	of	of	ADP
easat-2730	8	6	protective	protective	ADJ
easat-2730	8	7	actions	action	NOUN
easat-2730	8	8	facilitated	facilitate	VERB
easat-2730	8	9	by	by	ADP
easat-2730	8	10	the	the	DET
easat-2730	8	11	release	release	NOUN
easat-2730	8	12	of	of	ADP
easat-2730	8	13	nitric	nitric	ADJ
easat-2730	8	14	oxide	oxide	NOUN
easat-2730	8	15	(	(	PUNCT
easat-2730	8	16	no	no	NOUN
easat-2730	8	17	)	)	PUNCT
easat-2730	8	18	,	,	PUNCT
easat-2730	8	19	a	a	DET
easat-2730	8	20	soluble	soluble	ADJ
easat-2730	8	21	gas	gas	NOUN
easat-2730	8	22	that	that	PRON
easat-2730	8	23	is	be	AUX
easat-2730	8	24	generated	generate	VERB
easat-2730	8	25	in	in	ADP
easat-2730	8	26	endothelial	endothelial	ADJ
easat-2730	8	27	cells	cell	NOUN
easat-2730	8	28	by	by	ADP
easat-2730	8	29	the	the	DET
easat-2730	8	30	amino	amino	NOUN
easat-2730	8	31	acid	acid	PROPN
easat-2730	8	32	l	l	NOUN
easat-2730	8	33	-	-	NOUN
easat-2730	8	34	arginine	arginine	NOUN
easat-2730	8	35	through	through	ADP
easat-2730	8	36	the	the	DET
easat-2730	8	37	action	action	NOUN
easat-2730	8	38	of	of	ADP
easat-2730	8	39	endothelial	endothelial	ADJ
easat-2730	8	40	nitric	nitric	ADJ
easat-2730	8	41	oxide	oxide	NOUN
easat-2730	8	42	synthase	synthase	NOUN
easat-2730	8	43	(	(	PUNCT
easat-2730	8	44	enos	enos	PROPN
easat-2730	8	45	)	)	PUNCT
easat-2730	8	46	.	.	PUNCT
easat-2730	9	1	the	the	DET
easat-2730	9	2	maintenance	maintenance	NOUN
easat-2730	9	3	of	of	ADP
easat-2730	9	4	vascular	vascular	ADJ
easat-2730	9	5	homeostasis	homeostasis	NOUN
easat-2730	9	6	is	be	AUX
easat-2730	9	7	facilitated	facilitate	VERB
easat-2730	9	8	by	by	ADP
easat-2730	9	9	various	various	ADJ
easat-2730	9	10	biological	biological	ADJ
easat-2730	9	11	actions	action	NOUN
easat-2730	9	12	of	of	ADP
easat-2730	9	13	no	no	PRON
easat-2730	9	14	,	,	PUNCT
easat-2730	9	15	such	such	ADJ
easat-2730	9	16	as	as	ADP
easat-2730	9	17	modulation	modulation	NOUN
easat-2730	9	18	of	of	ADP
easat-2730	9	19	vascular	vascular	ADJ
easat-2730	9	20	dilator	dilator	NOUN
easat-2730	9	21	tone	tone	NOUN
easat-2730	9	22	,	,	PUNCT
easat-2730	9	23	control	control	NOUN
easat-2730	9	24	of	of	ADP
easat-2730	9	25	local	local	ADJ
easat-2730	9	26	cell	cell	NOUN
easat-2730	9	27	growth	growth	NOUN
easat-2730	9	28	,	,	PUNCT
easat-2730	9	29	and	and	CCONJ
easat-2730	9	30	protection	protection	NOUN
easat-2730	9	31	of	of	ADP
easat-2730	9	32	the	the	DET
easat-2730	9	33	endothelium	endothelium	NOUN
easat-2730	9	34	from	from	ADP
easat-2730	9	35	the	the	DET
easat-2730	9	36	harmful	harmful	ADJ
easat-2730	9	37	effects	effect	NOUN
easat-2730	9	38	of	of	ADP
easat-2730	9	39	cellular	cellular	ADJ
easat-2730	9	40	components	component	NOUN
easat-2730	9	41	in	in	ADP
easat-2730	9	42	blood	blood	NOUN
easat-2730	9	43	circulation	circulation	NOUN
easat-2730	9	44	,	,	PUNCT
easat-2730	9	45	while	while	SCONJ
easat-2730	9	46	maintaining	maintain	VERB
easat-2730	9	47	normal	normal	ADJ
easat-2730	9	48	endothelial	endothelial	ADJ
easat-2730	9	49	functions	function	NOUN
easat-2730	9	50	.	.	PUNCT
easat-2730	10	1	decreased	decrease	VERB
easat-2730	10	2	peripheral	peripheral	ADJ
easat-2730	10	3	arterial	arterial	ADJ
easat-2730	10	4	endothelium	endothelium	NOUN
easat-2730	10	5	-	-	PUNCT
easat-2730	10	6	dependent	dependent	ADJ
easat-2730	10	7	dilation	dilation	NOUN
easat-2730	10	8	(	(	PUNCT
easat-2730	10	9	edd	edd	PROPN
easat-2730	10	10	)	)	PUNCT
easat-2730	10	11	in	in	ADP
easat-2730	10	12	response	response	NOUN
easat-2730	10	13	to	to	ADP
easat-2730	10	14	mechanical	mechanical	ADJ
easat-2730	10	15	(	(	PUNCT
easat-2730	10	16	intravascular	intravascular	ADJ
easat-2730	10	17	shear	shear	NOUN
easat-2730	10	18	)	)	PUNCT
easat-2730	10	19	or	or	CCONJ
easat-2730	11	1	chemical	chemical	NOUN
easat-2730	11	2	(	(	PUNCT
easat-2730	11	3	acetylcholine	acetylcholine	NOUN
easat-2730	11	4	)	)	PUNCT
easat-2730	11	5	stimuli	stimulus	NOUN
easat-2730	11	6	suggests	suggest	VERB
easat-2730	11	7	that	that	PRON
easat-2730	11	8	decreased	decrease	VERB
easat-2730	11	9	no	no	DET
easat-2730	11	10	bioavailability	bioavailability	NOUN
easat-2730	11	11	has	have	AUX
easat-2730	11	12	been	be	AUX
easat-2730	11	13	recognised	recognise	VERB
easat-2730	11	14	as	as	ADP
easat-2730	11	15	major	major	ADJ
easat-2730	11	16	molecular	molecular	ADJ
easat-2730	11	17	mechanisms	mechanism	NOUN
easat-2730	11	18	associated	associate	VERB
easat-2730	11	19	with	with	ADP
easat-2730	11	20	the	the	DET
easat-2730	11	21	progress	progress	NOUN
easat-2730	11	22	and	and	CCONJ
easat-2730	11	23	development	development	NOUN
easat-2730	11	24	of	of	ADP
easat-2730	11	25	obesity	obesity	NOUN
easat-2730	11	26	-	-	PUNCT
easat-2730	11	27	induced	induce	VERB
easat-2730	11	28	endothelial	endothelial	ADJ
easat-2730	11	29	dysfunction	dysfunction	NOUN
easat-2730	11	30	.	.	PUNCT
easat-2730	12	1	in	in	ADP
easat-2730	12	2	this	this	DET
easat-2730	12	3	review	review	NOUN
easat-2730	12	4	,	,	PUNCT
easat-2730	12	5	the	the	DET
easat-2730	12	6	modulatory	modulatory	ADJ
easat-2730	12	7	effects	effect	NOUN
easat-2730	12	8	of	of	ADP
easat-2730	12	9	no	no	PRON
easat-2730	12	10	in	in	ADP
easat-2730	12	11	obesity	obesity	NOUN
easat-2730	12	12	-	-	PUNCT
easat-2730	12	13	induced	induce	VERB
easat-2730	12	14	endothelial	endothelial	ADJ
easat-2730	12	15	dysfunction	dysfunction	NOUN
easat-2730	12	16	will	will	AUX
easat-2730	12	17	be	be	AUX
easat-2730	12	18	discussed	discuss	VERB
easat-2730	12	19	.	.	PUNCT
easat-2730	13	1	keywords	keyword	NOUN
easat-2730	13	2	:	:	PUNCT
easat-2730	13	3	endothelial	endothelial	ADJ
easat-2730	13	4	dysfunction	dysfunction	NOUN
easat-2730	13	5	,	,	PUNCT
easat-2730	13	6	endothelial	endothelial	ADJ
easat-2730	13	7	nitric	nitric	ADJ
easat-2730	13	8	oxide	oxide	NOUN
easat-2730	13	9	synthases	synthase	NOUN
easat-2730	13	10	,	,	PUNCT
easat-2730	13	11	nitric	nitric	ADJ
easat-2730	13	12	oxide	oxide	NOUN
easat-2730	13	13	,	,	PUNCT
easat-2730	13	14	obesity	obesity	NOUN
easat-2730	13	15	.	.	PUNCT
easat-2730	14	1	1	1	X
easat-2730	14	2	.	.	X
easat-2730	14	3	introduction	introduction	NOUN
easat-2730	14	4	the	the	DET
easat-2730	14	5	prevalence	prevalence	NOUN
easat-2730	14	6	of	of	ADP
easat-2730	14	7	various	various	ADJ
easat-2730	14	8	clinical	clinical	ADJ
easat-2730	14	9	condition	condition	NOUN
easat-2730	14	10	associated	associate	VERB
easat-2730	14	11	with	with	ADP
easat-2730	14	12	obesity	obesity	NOUN
easat-2730	14	13	-	-	PUNCT
easat-2730	14	14	related	relate	VERB
easat-2730	14	15	metabolic	metabolic	NOUN
easat-2730	14	16	conditions	condition	NOUN
easat-2730	14	17	has	have	AUX
easat-2730	14	18	increased	increase	VERB
easat-2730	14	19	significantly	significantly	ADV
easat-2730	14	20	,	,	PUNCT
easat-2730	14	21	as	as	ADP
easat-2730	14	22	a	a	DET
easat-2730	14	23	result	result	NOUN
easat-2730	14	24	of	of	ADP
easat-2730	14	25	the	the	DET
easat-2730	14	26	exponential	exponential	ADJ
easat-2730	14	27	increase	increase	NOUN
easat-2730	14	28	in	in	ADP
easat-2730	14	29	obesity	obesity	NOUN
easat-2730	14	30	incidence	incidence	NOUN
easat-2730	14	31	.	.	PUNCT
easat-2730	15	1	currently	currently	ADV
easat-2730	15	2	,	,	PUNCT
easat-2730	15	3	it	it	PRON
easat-2730	15	4	is	be	AUX
easat-2730	15	5	estimated	estimate	VERB
easat-2730	15	6	that	that	SCONJ
easat-2730	15	7	1.9	1.9	NUM
easat-2730	15	8	billion	billion	NUM
easat-2730	15	9	people	people	NOUN
easat-2730	15	10	worldwide	worldwide	ADV
easat-2730	15	11	are	be	AUX
easat-2730	15	12	obese	obese	ADJ
easat-2730	15	13	or	or	CCONJ
easat-2730	15	14	overweight	overweight	ADJ
easat-2730	15	15	,	,	PUNCT
easat-2730	15	16	with	with	ADP
easat-2730	15	17	50	50	NUM
easat-2730	15	18	million	million	NUM
easat-2730	15	19	of	of	ADP
easat-2730	15	20	these	these	PRON
easat-2730	15	21	being	be	AUX
easat-2730	15	22	children	child	NOUN
easat-2730	15	23	under	under	ADP
easat-2730	15	24	the	the	DET
easat-2730	15	25	age	age	NOUN
easat-2730	15	26	of	of	ADP
easat-2730	15	27	five	five	NUM
easat-2730	15	28	[	[	X
easat-2730	15	29	1	1	NUM
easat-2730	15	30	]	]	PUNCT
easat-2730	15	31	.	.	PUNCT
easat-2730	16	1	obesity	obesity	NOUN
easat-2730	16	2	describes	describe	VERB
easat-2730	16	3	excessive	excessive	ADJ
easat-2730	16	4	accumulation	accumulation	NOUN
easat-2730	16	5	of	of	ADP
easat-2730	16	6	body	body	NOUN
easat-2730	16	7	fat	fat	NOUN
easat-2730	16	8	,	,	PUNCT
easat-2730	16	9	described	describe	VERB
easat-2730	16	10	by	by	ADP
easat-2730	16	11	the	the	DET
easat-2730	16	12	body	body	NOUN
easat-2730	16	13	mass	mass	NOUN
easat-2730	16	14	index	index	NOUN
easat-2730	16	15	(	(	PUNCT
easat-2730	16	16	bmi	bmi	PROPN
easat-2730	16	17	)	)	PUNCT
easat-2730	16	18	,	,	PUNCT
easat-2730	16	19	which	which	PRON
easat-2730	16	20	is	be	AUX
easat-2730	16	21	computed	compute	VERB
easat-2730	16	22	as	as	ADP
easat-2730	16	23	weight	weight	NOUN
easat-2730	16	24	(	(	PUNCT
easat-2730	16	25	kg	kg	NOUN
easat-2730	16	26	)	)	PUNCT
easat-2730	16	27	divided	divide	VERB
easat-2730	16	28	by	by	ADP
easat-2730	16	29	height	height	NOUN
easat-2730	16	30	(	(	PUNCT
easat-2730	16	31	meters	meter	NOUN
easat-2730	16	32	)	)	PUNCT
easat-2730	16	33	squared	square	VERB
easat-2730	16	34	.	.	PUNCT
easat-2730	17	1	it	it	PRON
easat-2730	17	2	is	be	AUX
easat-2730	17	3	a	a	DET
easat-2730	17	4	global	global	ADJ
easat-2730	17	5	issue	issue	NOUN
easat-2730	17	6	that	that	PRON
easat-2730	17	7	affects	affect	VERB
easat-2730	17	8	both	both	CCONJ
easat-2730	17	9	developed	developed	ADJ
easat-2730	17	10	and	and	CCONJ
easat-2730	17	11	low	low	ADJ
easat-2730	17	12	-	-	PUNCT
easat-2730	17	13	resource	resource	NOUN
easat-2730	17	14	countries	country	NOUN
easat-2730	17	15	.	.	PUNCT
easat-2730	18	1	bmi	bmi	PROPN
easat-2730	18	2	levels	level	NOUN
easat-2730	18	3	higher	high	ADJ
easat-2730	18	4	than	than	ADP
easat-2730	18	5	19	19	NUM
easat-2730	18	6	and	and	CCONJ
easat-2730	18	7	less	less	ADJ
easat-2730	18	8	than	than	ADP
easat-2730	18	9	25	25	NUM
easat-2730	18	10	kg	kg	NOUN
easat-2730	18	11	/	/	SYM
easat-2730	18	12	m2	m2	PROPN
easat-2730	18	13	are	be	AUX
easat-2730	18	14	regarded	regard	VERB
easat-2730	18	15	as	as	ADP
easat-2730	18	16	normal	normal	ADJ
easat-2730	18	17	,	,	PUNCT
easat-2730	18	18	whereas	whereas	SCONJ
easat-2730	18	19	bmi	bmi	NOUN
easat-2730	18	20	values	value	NOUN
easat-2730	18	21	of	of	ADP
easat-2730	18	22	equal	equal	ADJ
easat-2730	18	23	to	to	ADP
easat-2730	18	24	or	or	CCONJ
easat-2730	18	25	higher	high	ADJ
easat-2730	18	26	than	than	ADP
easat-2730	18	27	25	25	NUM
easat-2730	18	28	kg	kg	NOUN
easat-2730	18	29	/	/	SYM
easat-2730	18	30	m2	m2	PROPN
easat-2730	18	31	are	be	AUX
easat-2730	18	32	regarded	regard	VERB
easat-2730	18	33	as	as	ADP
easat-2730	18	34	overweight	overweight	ADJ
easat-2730	18	35	,	,	PUNCT
easat-2730	18	36	while	while	SCONJ
easat-2730	18	37	bmi	bmi	NOUN
easat-2730	18	38	values	value	NOUN
easat-2730	18	39	of	of	ADP
easat-2730	18	40	equal	equal	ADJ
easat-2730	18	41	to	to	ADP
easat-2730	18	42	or	or	CCONJ
easat-2730	18	43	higher	high	ADJ
easat-2730	18	44	than	than	ADP
easat-2730	18	45	30	30	NUM
easat-2730	18	46	kg	kg	NOUN
easat-2730	18	47	/	/	SYM
easat-2730	18	48	m2	m2	PROPN
easat-2730	18	49	are	be	AUX
easat-2730	18	50	regarded	regard	VERB
easat-2730	18	51	as	as	ADP
easat-2730	18	52	obese	obese	NOUN
easat-2730	18	53	[	[	X
easat-2730	18	54	2	2	NUM
easat-2730	18	55	]	]	PUNCT
easat-2730	18	56	.	.	PUNCT
easat-2730	19	1	increased	increase	VERB
easat-2730	19	2	calorie	calorie	ADJ
easat-2730	19	3	consumption	consumption	NOUN
easat-2730	19	4	and	and	CCONJ
easat-2730	19	5	physical	physical	ADJ
easat-2730	19	6	inactivity	inactivity	NOUN
easat-2730	19	7	are	be	AUX
easat-2730	19	8	the	the	DET
easat-2730	19	9	two	two	NUM
easat-2730	19	10	main	main	ADJ
easat-2730	19	11	factors	factor	NOUN
easat-2730	19	12	contributing	contribute	VERB
easat-2730	19	13	tremendously	tremendously	ADV
easat-2730	19	14	to	to	ADP
easat-2730	19	15	the	the	DET
easat-2730	19	16	progress	progress	NOUN
easat-2730	19	17	of	of	ADP
easat-2730	19	18	obesity	obesity	NOUN
easat-2730	19	19	.	.	PUNCT
easat-2730	20	1	these	these	DET
easat-2730	20	2	factors	factor	NOUN
easat-2730	20	3	result	result	VERB
easat-2730	20	4	in	in	ADP
easat-2730	20	5	a	a	DET
easat-2730	20	6	positive	positive	ADJ
easat-2730	20	7	calorie	calorie	NOUN
easat-2730	20	8	balance	balance	NOUN
easat-2730	20	9	and	and	CCONJ
easat-2730	20	10	a	a	DET
easat-2730	20	11	corresponding	corresponding	ADJ
easat-2730	20	12	rise	rise	NOUN
easat-2730	20	13	in	in	ADP
easat-2730	20	14	body	body	NOUN
easat-2730	20	15	fat	fat	ADJ
easat-2730	20	16	percentage	percentage	NOUN
easat-2730	20	17	.	.	PUNCT
easat-2730	21	1	factors	factor	NOUN
easat-2730	21	2	,	,	PUNCT
easat-2730	21	3	such	such	ADJ
easat-2730	21	4	as	as	ADP
easat-2730	21	5	tumour	tumour	NOUN
easat-2730	21	6	necrosis	necrosis	NOUN
easat-2730	21	7	factor	factor	NOUN
easat-2730	21	8	-	-	PUNCT
easat-2730	21	9	a	a	PRON
easat-2730	21	10	(	(	PUNCT
easat-2730	21	11	tnf	tnf	PROPN
easat-2730	21	12	-	-	PUNCT
easat-2730	21	13	a	a	NOUN
easat-2730	21	14	)	)	PUNCT
easat-2730	21	15	,	,	PUNCT
easat-2730	21	16	interleukin-6	interleukin-6	PROPN
easat-2730	21	17	(	(	PUNCT
easat-2730	21	18	il-6	il-6	NUM
easat-2730	21	19	)	)	PUNCT
easat-2730	21	20	,	,	PUNCT
easat-2730	21	21	adipsin	adipsin	NOUN
easat-2730	21	22	,	,	PUNCT
easat-2730	21	23	angiotensinogen	angiotensinogen	NOUN
easat-2730	21	24	,	,	PUNCT
easat-2730	21	25	adiponectin	adiponectin	NOUN
easat-2730	21	26	,	,	PUNCT
easat-2730	21	27	resistin	resistin	NOUN
easat-2730	21	28	,	,	PUNCT
easat-2730	21	29	and	and	CCONJ
easat-2730	21	30	leptin	leptin	NOUN
easat-2730	21	31	are	be	AUX
easat-2730	21	32	the	the	DET
easat-2730	21	33	active	active	ADJ
easat-2730	21	34	substances	substance	NOUN
easat-2730	21	35	3442	3442	NUM
easat-2730	21	36	edelweiss	edelweiss	PROPN
easat-2730	21	37	applied	apply	VERB
easat-2730	21	38	science	science	NOUN
easat-2730	21	39	and	and	CCONJ
easat-2730	21	40	technology	technology	NOUN
easat-2730	21	41	issn	issn	PROPN
easat-2730	21	42	:	:	PUNCT
easat-2730	21	43	2576	2576	NUM
easat-2730	21	44	-	-	SYM
easat-2730	21	45	8484	8484	NUM
easat-2730	21	46	vol	vol	NOUN
easat-2730	21	47	.	.	PROPN
easat-2730	21	48	8	8	NUM
easat-2730	21	49	,	,	PUNCT
easat-2730	21	50	no	no	INTJ
easat-2730	21	51	.	.	NOUN
easat-2730	21	52	6	6	NUM
easat-2730	21	53	:	:	SYM
easat-2730	21	54	3441	3441	NUM
easat-2730	21	55	-	-	SYM
easat-2730	21	56	3456	3456	NUM
easat-2730	21	57	,	,	PUNCT
easat-2730	21	58	2024	2024	NUM
easat-2730	21	59	doi	doi	NOUN
easat-2730	21	60	:	:	PUNCT
easat-2730	21	61	10.55214/25768484.v8i6.2730	10.55214/25768484.v8i6.2730	NUM
easat-2730	21	62	©	©	ADP
easat-2730	21	63	2024	2024	NUM
easat-2730	21	64	by	by	ADP
easat-2730	21	65	the	the	DET
easat-2730	21	66	authors	author	NOUN
easat-2730	21	67	;	;	PUNCT
easat-2730	21	68	licensee	licensee	PROPN
easat-2730	21	69	learning	learn	VERB
easat-2730	21	70	gate	gate	NOUN
easat-2730	21	71	released	release	VERB
easat-2730	21	72	by	by	ADP
easat-2730	21	73	adipose	adipose	ADJ
easat-2730	21	74	tissue	tissue	NOUN
easat-2730	21	75	,	,	PUNCT
easat-2730	21	76	which	which	PRON
easat-2730	21	77	are	be	AUX
easat-2730	21	78	passed	pass	VERB
easat-2730	21	79	to	to	ADP
easat-2730	21	80	the	the	DET
easat-2730	21	81	organ	organ	NOUN
easat-2730	21	82	that	that	PRON
easat-2730	21	83	stores	store	VERB
easat-2730	21	84	energy	energy	NOUN
easat-2730	21	85	.	.	PUNCT
easat-2730	22	1	these	these	DET
easat-2730	22	2	substances	substance	NOUN
easat-2730	22	3	may	may	AUX
easat-2730	22	4	also	also	ADV
easat-2730	22	5	promote	promote	VERB
easat-2730	22	6	obesity	obesity	NOUN
easat-2730	22	7	-	-	PUNCT
easat-2730	22	8	induced	induce	VERB
easat-2730	22	9	endothelial	endothelial	ADJ
easat-2730	22	10	dysfunction	dysfunction	NOUN
easat-2730	23	1	[	[	X
easat-2730	23	2	3	3	NUM
easat-2730	23	3	]	]	PUNCT
easat-2730	23	4	.	.	PUNCT
easat-2730	24	1	vascular	vascular	ADJ
easat-2730	24	2	endothelium	endothelium	NOUN
easat-2730	24	3	is	be	AUX
easat-2730	24	4	extremely	extremely	ADV
easat-2730	24	5	dynamic	dynamic	ADJ
easat-2730	24	6	that	that	SCONJ
easat-2730	24	7	syntheses	synthese	VERB
easat-2730	24	8	various	various	ADJ
easat-2730	24	9	molecules	molecule	NOUN
easat-2730	24	10	which	which	PRON
easat-2730	24	11	work	work	VERB
easat-2730	24	12	in	in	ADP
easat-2730	24	13	both	both	PRON
easat-2730	24	14	autocrine	autocrine	NOUN
easat-2730	24	15	and	and	CCONJ
easat-2730	24	16	paracrine	paracrine	NOUN
easat-2730	24	17	manner	manner	NOUN
easat-2730	24	18	to	to	PART
easat-2730	24	19	regulate	regulate	VERB
easat-2730	24	20	the	the	DET
easat-2730	24	21	normal	normal	ADJ
easat-2730	24	22	function	function	NOUN
easat-2730	24	23	of	of	ADP
easat-2730	24	24	the	the	DET
easat-2730	24	25	vascular	vascular	ADJ
easat-2730	24	26	network	network	NOUN
easat-2730	24	27	.	.	PUNCT
easat-2730	25	1	it	it	PRON
easat-2730	25	2	regulates	regulate	VERB
easat-2730	25	3	blood	blood	NOUN
easat-2730	25	4	flow	flow	NOUN
easat-2730	25	5	in	in	ADP
easat-2730	25	6	a	a	DET
easat-2730	25	7	fluid	fluid	ADJ
easat-2730	25	8	state	state	NOUN
easat-2730	25	9	,	,	PUNCT
easat-2730	25	10	provides	provide	VERB
easat-2730	25	11	fluid	fluid	ADJ
easat-2730	25	12	and	and	CCONJ
easat-2730	25	13	molecules	molecule	NOUN
easat-2730	25	14	exchange	exchange	NOUN
easat-2730	25	15	between	between	ADP
easat-2730	25	16	the	the	DET
easat-2730	25	17	blood	blood	NOUN
easat-2730	25	18	and	and	CCONJ
easat-2730	25	19	surrounding	surround	VERB
easat-2730	25	20	tissues	tissue	NOUN
easat-2730	25	21	,	,	PUNCT
easat-2730	25	22	initiates	initiate	VERB
easat-2730	25	23	vascular	vascular	ADJ
easat-2730	25	24	networks	network	NOUN
easat-2730	25	25	,	,	PUNCT
easat-2730	25	26	and	and	CCONJ
easat-2730	25	27	regulates	regulate	VERB
easat-2730	25	28	vascular	vascular	ADJ
easat-2730	25	29	resistance	resistance	NOUN
easat-2730	25	30	in	in	ADP
easat-2730	25	31	response	response	NOUN
easat-2730	25	32	to	to	ADP
easat-2730	25	33	changes	change	NOUN
easat-2730	25	34	in	in	ADP
easat-2730	25	35	vascular	vascular	ADJ
easat-2730	25	36	blood	blood	NOUN
easat-2730	25	37	flow	flow	NOUN
easat-2730	25	38	,	,	PUNCT
easat-2730	25	39	as	as	ADV
easat-2730	25	40	well	well	ADV
easat-2730	25	41	as	as	ADP
easat-2730	25	42	controlling	control	VERB
easat-2730	25	43	arterial	arterial	ADJ
easat-2730	25	44	tone	tone	NOUN
easat-2730	25	45	in	in	ADP
easat-2730	25	46	resistance	resistance	NOUN
easat-2730	25	47	vessels	vessel	NOUN
easat-2730	25	48	[	[	X
easat-2730	25	49	4	4	NUM
easat-2730	25	50	]	]	PUNCT
easat-2730	25	51	.	.	PUNCT
easat-2730	26	1	the	the	DET
easat-2730	26	2	endothelium	endothelium	NOUN
easat-2730	26	3	could	could	AUX
easat-2730	26	4	achieved	achieve	VERB
easat-2730	26	5	these	these	DET
easat-2730	26	6	roles	role	NOUN
easat-2730	26	7	by	by	ADP
easat-2730	26	8	the	the	DET
easat-2730	26	9	synthesis	synthesis	NOUN
easat-2730	26	10	of	of	ADP
easat-2730	26	11	endothelial	endothelial	ADJ
easat-2730	26	12	cells	cell	NOUN
easat-2730	26	13	moieties	moiety	NOUN
easat-2730	26	14	through	through	ADP
easat-2730	26	15	its	its	PRON
easat-2730	26	16	paracrine	paracrine	NOUN
easat-2730	26	17	and	and	CCONJ
easat-2730	26	18	autocrine	autocrine	NOUN
easat-2730	26	19	activities	activity	NOUN
easat-2730	26	20	and	and	CCONJ
easat-2730	26	21	many	many	ADJ
easat-2730	26	22	regulatory	regulatory	ADJ
easat-2730	26	23	mediators	mediator	NOUN
easat-2730	26	24	,	,	PUNCT
easat-2730	26	25	including	include	VERB
easat-2730	26	26	no	no	PRON
easat-2730	26	27	[	[	X
easat-2730	26	28	2	2	NUM
easat-2730	26	29	,	,	PUNCT
easat-2730	26	30	3	3	NUM
easat-2730	26	31	,	,	PUNCT
easat-2730	26	32	4	4	NUM
easat-2730	26	33	]	]	PUNCT
easat-2730	26	34	.	.	PUNCT
easat-2730	27	1	disturbances	disturbance	NOUN
easat-2730	27	2	in	in	ADP
easat-2730	27	3	endothelial	endothelial	ADJ
easat-2730	27	4	functions	function	NOUN
easat-2730	27	5	were	be	AUX
easat-2730	27	6	investigated	investigate	VERB
easat-2730	27	7	to	to	PART
easat-2730	27	8	facilitate	facilitate	VERB
easat-2730	27	9	the	the	DET
easat-2730	27	10	progress	progress	NOUN
easat-2730	27	11	of	of	ADP
easat-2730	27	12	atherosclerotic	atherosclerotic	ADJ
easat-2730	27	13	endothelial	endothelial	ADJ
easat-2730	27	14	dysfunction	dysfunction	NOUN
easat-2730	27	15	,	,	PUNCT
easat-2730	27	16	leading	lead	VERB
easat-2730	27	17	to	to	ADP
easat-2730	27	18	cvds	cvds	PROPN
easat-2730	27	19	[	[	X
easat-2730	27	20	5	5	NUM
easat-2730	27	21	,	,	PUNCT
easat-2730	27	22	6	6	NUM
easat-2730	27	23	,	,	PUNCT
easat-2730	27	24	7	7	NUM
easat-2730	27	25	]	]	PUNCT
easat-2730	27	26	.	.	PUNCT
easat-2730	28	1	no	no	PRON
easat-2730	28	2	is	be	AUX
easat-2730	28	3	the	the	DET
easat-2730	28	4	major	major	ADJ
easat-2730	28	5	significant	significant	ADJ
easat-2730	28	6	substance	substance	NOUN
easat-2730	28	7	secreted	secrete	VERB
easat-2730	28	8	by	by	ADP
easat-2730	28	9	the	the	DET
easat-2730	28	10	endothelium	endothelium	NOUN
easat-2730	28	11	,	,	PUNCT
easat-2730	28	12	and	and	CCONJ
easat-2730	28	13	is	be	AUX
easat-2730	28	14	crucial	crucial	ADJ
easat-2730	28	15	for	for	ADP
easat-2730	28	16	vasodilation	vasodilation	NOUN
easat-2730	28	17	,	,	PUNCT
easat-2730	28	18	attenuating	attenuate	VERB
easat-2730	28	19	inflammatory	inflammatory	ADJ
easat-2730	28	20	response	response	NOUN
easat-2730	28	21	,	,	PUNCT
easat-2730	28	22	and	and	CCONJ
easat-2730	28	23	oxidative	oxidative	ADJ
easat-2730	28	24	stress	stress	NOUN
easat-2730	28	25	,	,	PUNCT
easat-2730	28	26	produced	produce	VERB
easat-2730	28	27	mostly	mostly	ADV
easat-2730	28	28	from	from	ADP
easat-2730	28	29	ros	ros	PROPN
easat-2730	28	30	[	[	X
easat-2730	28	31	8	8	NUM
easat-2730	28	32	]	]	PUNCT
easat-2730	28	33	.	.	PUNCT
easat-2730	29	1	reduced	reduce	VERB
easat-2730	29	2	no	no	DET
easat-2730	29	3	bioavailability	bioavailability	NOUN
easat-2730	29	4	may	may	AUX
easat-2730	29	5	lead	lead	VERB
easat-2730	29	6	to	to	ADP
easat-2730	29	7	coronary	coronary	ADJ
easat-2730	29	8	artery	artery	NOUN
easat-2730	29	9	constriction	constriction	NOUN
easat-2730	29	10	during	during	ADP
easat-2730	29	11	physical	physical	ADJ
easat-2730	29	12	activity	activity	NOUN
easat-2730	29	13	or	or	CCONJ
easat-2730	29	14	mental	mental	ADJ
easat-2730	29	15	stress	stress	NOUN
easat-2730	29	16	,	,	PUNCT
easat-2730	29	17	which	which	PRON
easat-2730	29	18	could	could	AUX
easat-2730	29	19	provoke	provoke	VERB
easat-2730	29	20	myocardial	myocardial	ADJ
easat-2730	29	21	ischemia	ischemia	NOUN
easat-2730	29	22	and	and	CCONJ
easat-2730	29	23	ischemic	ischemic	ADJ
easat-2730	29	24	heart	heart	NOUN
easat-2730	29	25	stroke	stroke	NOUN
easat-2730	29	26	in	in	ADP
easat-2730	29	27	patients	patient	NOUN
easat-2730	29	28	with	with	ADP
easat-2730	29	29	coronary	coronary	ADJ
easat-2730	29	30	artery	artery	NOUN
easat-2730	29	31	disease	disease	NOUN
easat-2730	29	32	.	.	PUNCT
easat-2730	30	1	furthermore	furthermore	ADV
easat-2730	30	2	,	,	PUNCT
easat-2730	30	3	decreased	decrease	VERB
easat-2730	30	4	no	no	DET
easat-2730	30	5	bioavailability	bioavailability	NOUN
easat-2730	30	6	can	can	AUX
easat-2730	30	7	promote	promote	VERB
easat-2730	30	8	vascular	vascular	ADJ
easat-2730	30	9	inflammation	inflammation	NOUN
easat-2730	30	10	,	,	PUNCT
easat-2730	30	11	which	which	PRON
easat-2730	30	12	might	might	AUX
easat-2730	30	13	result	result	VERB
easat-2730	30	14	in	in	ADP
easat-2730	30	15	the	the	DET
easat-2730	30	16	oxidation	oxidation	NOUN
easat-2730	30	17	of	of	ADP
easat-2730	30	18	lipoproteins	lipoprotein	NOUN
easat-2730	30	19	and	and	CCONJ
easat-2730	30	20	the	the	DET
easat-2730	30	21	development	development	NOUN
easat-2730	30	22	of	of	ADP
easat-2730	30	23	foam	foam	NOUN
easat-2730	30	24	cells	cell	NOUN
easat-2730	30	25	,	,	PUNCT
easat-2730	30	26	the	the	DET
easat-2730	30	27	precursor	precursor	NOUN
easat-2730	30	28	to	to	ADP
easat-2730	30	29	atherosclerotic	atherosclerotic	ADJ
easat-2730	30	30	plaque	plaque	NOUN
easat-2730	30	31	[	[	X
easat-2730	30	32	8	8	NUM
easat-2730	30	33	]	]	PUNCT
easat-2730	30	34	.	.	PUNCT
easat-2730	31	1	impaired	impair	VERB
easat-2730	31	2	endothelium	endothelium	NOUN
easat-2730	31	3	functions	function	NOUN
easat-2730	31	4	have	have	AUX
easat-2730	31	5	been	be	AUX
easat-2730	31	6	associated	associate	VERB
easat-2730	31	7	with	with	ADP
easat-2730	31	8	a	a	DET
easat-2730	31	9	growing	grow	VERB
easat-2730	31	10	number	number	NOUN
easat-2730	31	11	of	of	ADP
easat-2730	31	12	diseases	disease	NOUN
easat-2730	31	13	,	,	PUNCT
easat-2730	31	14	such	such	ADJ
easat-2730	31	15	as	as	ADP
easat-2730	31	16	hyperhomocysteinaemia	hyperhomocysteinaemia	NOUN
easat-2730	31	17	,	,	PUNCT
easat-2730	31	18	congestive	congestive	ADJ
easat-2730	31	19	heart	heart	NOUN
easat-2730	31	20	failure	failure	NOUN
easat-2730	31	21	,	,	PUNCT
easat-2730	31	22	hypertension	hypertension	NOUN
easat-2730	31	23	,	,	PUNCT
easat-2730	31	24	smoking	smoking	NOUN
easat-2730	31	25	,	,	PUNCT
easat-2730	31	26	diabetes	diabetes	NOUN
easat-2730	31	27	,	,	PUNCT
easat-2730	31	28	hypercholesterolemia	hypercholesterolemia	NOUN
easat-2730	31	29	,	,	PUNCT
easat-2730	31	30	hyperlipidaemia	hyperlipidaemia	NOUN
easat-2730	31	31	and	and	CCONJ
easat-2730	31	32	obesity	obesity	NOUN
easat-2730	31	33	[	[	X
easat-2730	31	34	2	2	NUM
easat-2730	31	35	,	,	PUNCT
easat-2730	31	36	6	6	NUM
easat-2730	31	37	]	]	PUNCT
easat-2730	31	38	.	.	PUNCT
easat-2730	32	1	hence	hence	ADV
easat-2730	32	2	,	,	PUNCT
easat-2730	32	3	the	the	DET
easat-2730	32	4	vascular	vascular	ADJ
easat-2730	32	5	endothelial	endothelial	NOUN
easat-2730	32	6	wall	wall	NOUN
easat-2730	32	7	in	in	ADP
easat-2730	32	8	these	these	DET
easat-2730	32	9	circumstances	circumstance	NOUN
easat-2730	32	10	may	may	AUX
easat-2730	32	11	enhance	enhance	VERB
easat-2730	32	12	inflammation	inflammation	NOUN
easat-2730	32	13	,	,	PUNCT
easat-2730	32	14	oxidation	oxidation	NOUN
easat-2730	32	15	of	of	ADP
easat-2730	32	16	lipoproteins	lipoprotein	NOUN
easat-2730	32	17	,	,	PUNCT
easat-2730	32	18	extracellular	extracellular	ADJ
easat-2730	32	19	matrix	matrix	NOUN
easat-2730	32	20	accumulation	accumulation	NOUN
easat-2730	32	21	or	or	CCONJ
easat-2730	32	22	lysis	lysis	NOUN
easat-2730	32	23	,	,	PUNCT
easat-2730	32	24	deposition	deposition	NOUN
easat-2730	32	25	of	of	ADP
easat-2730	32	26	lipid	lipid	NOUN
easat-2730	32	27	-	-	PUNCT
easat-2730	32	28	rich	rich	ADJ
easat-2730	32	29	materials	material	NOUN
easat-2730	32	30	,	,	PUNCT
easat-2730	32	31	smooth	smooth	ADJ
easat-2730	32	32	muscle	muscle	NOUN
easat-2730	32	33	proliferation	proliferation	NOUN
easat-2730	32	34	,	,	PUNCT
easat-2730	32	35	activation	activation	NOUN
easat-2730	32	36	,	,	PUNCT
easat-2730	32	37	adhesion	adhesion	NOUN
easat-2730	32	38	and	and	CCONJ
easat-2730	32	39	aggregation	aggregation	NOUN
easat-2730	32	40	of	of	ADP
easat-2730	32	41	platelet	platelet	NOUN
easat-2730	32	42	and	and	CCONJ
easat-2730	32	43	development	development	NOUN
easat-2730	32	44	of	of	ADP
easat-2730	32	45	thrombus	thrombus	NOUN
easat-2730	32	46	.	.	PUNCT
easat-2730	33	1	the	the	DET
easat-2730	33	2	detrimental	detrimental	ADJ
easat-2730	33	3	effects	effect	NOUN
easat-2730	33	4	of	of	ADP
easat-2730	33	5	ed	ed	NOUN
easat-2730	33	6	may	may	AUX
easat-2730	33	7	influence	influence	VERB
easat-2730	33	8	the	the	DET
easat-2730	33	9	progress	progress	NOUN
easat-2730	33	10	and	and	CCONJ
easat-2730	33	11	development	development	NOUN
easat-2730	33	12	of	of	ADP
easat-2730	33	13	cvds	cvds	PROPN
easat-2730	33	14	,	,	PUNCT
easat-2730	33	15	which	which	PRON
easat-2730	33	16	could	could	AUX
easat-2730	33	17	be	be	AUX
easat-2730	33	18	ameliorated	ameliorate	VERB
easat-2730	33	19	by	by	ADP
easat-2730	33	20	no	no	DET
easat-2730	33	21	molecules	molecule	NOUN
easat-2730	33	22	[	[	X
easat-2730	33	23	9	9	NUM
easat-2730	33	24	]	]	PUNCT
easat-2730	33	25	.	.	PUNCT
easat-2730	34	1	in	in	ADP
easat-2730	34	2	this	this	DET
easat-2730	34	3	review	review	NOUN
easat-2730	34	4	,	,	PUNCT
easat-2730	34	5	the	the	DET
easat-2730	34	6	functions	function	NOUN
easat-2730	34	7	of	of	ADP
easat-2730	34	8	endothelium	endothelium	NOUN
easat-2730	34	9	and	and	CCONJ
easat-2730	34	10	the	the	DET
easat-2730	34	11	molecular	molecular	ADJ
easat-2730	34	12	mechanisms	mechanism	NOUN
easat-2730	34	13	associated	associate	VERB
easat-2730	34	14	with	with	ADP
easat-2730	34	15	obesity	obesity	NOUN
easat-2730	34	16	-	-	PUNCT
easat-2730	34	17	induced	induce	VERB
easat-2730	34	18	endothelial	endothelial	ADJ
easat-2730	34	19	dysfunction	dysfunction	NOUN
easat-2730	34	20	would	would	AUX
easat-2730	34	21	be	be	AUX
easat-2730	34	22	discussed	discuss	VERB
easat-2730	34	23	.	.	PUNCT
easat-2730	35	1	the	the	DET
easat-2730	35	2	chapter	chapter	NOUN
easat-2730	35	3	also	also	ADV
easat-2730	35	4	summarized	summarize	VERB
easat-2730	35	5	the	the	DET
easat-2730	35	6	significant	significant	ADJ
easat-2730	35	7	role	role	NOUN
easat-2730	35	8	played	play	VERB
easat-2730	35	9	by	by	ADP
easat-2730	35	10	no	no	PRON
easat-2730	35	11	as	as	ADP
easat-2730	35	12	a	a	DET
easat-2730	35	13	potential	potential	ADJ
easat-2730	35	14	modulator	modulator	NOUN
easat-2730	35	15	of	of	ADP
easat-2730	35	16	obesity	obesity	NOUN
easat-2730	35	17	-	-	PUNCT
easat-2730	35	18	induced	induce	VERB
easat-2730	35	19	endothelial	endothelial	ADJ
easat-2730	35	20	dysfunction	dysfunction	NOUN
easat-2730	35	21	and	and	CCONJ
easat-2730	35	22	the	the	DET
easat-2730	35	23	therapeutic	therapeutic	ADJ
easat-2730	35	24	approaches	approach	NOUN
easat-2730	35	25	to	to	PART
easat-2730	35	26	be	be	AUX
easat-2730	35	27	employed	employ	VERB
easat-2730	35	28	to	to	PART
easat-2730	35	29	determine	determine	VERB
easat-2730	35	30	the	the	DET
easat-2730	35	31	possibility	possibility	NOUN
easat-2730	35	32	of	of	ADP
easat-2730	35	33	reversing	reverse	VERB
easat-2730	35	34	ed	ed	NOUN
easat-2730	35	35	by	by	ADP
easat-2730	35	36	facilitating	facilitate	VERB
easat-2730	35	37	the	the	DET
easat-2730	35	38	release	release	NOUN
easat-2730	35	39	of	of	ADP
easat-2730	35	40	no	no	PRON
easat-2730	35	41	from	from	ADP
easat-2730	35	42	the	the	DET
easat-2730	35	43	endothelium	endothelium	NOUN
easat-2730	35	44	.	.	PUNCT
easat-2730	36	1	2	2	NUM
easat-2730	36	2	.	.	X
easat-2730	36	3	normal	normal	ADJ
easat-2730	36	4	endothelium	endothelium	NOUN
easat-2730	36	5	endothelium	endothelium	NOUN
easat-2730	36	6	is	be	AUX
easat-2730	36	7	the	the	DET
easat-2730	36	8	innermost	innermost	ADJ
easat-2730	36	9	monolayer	monolayer	NOUN
easat-2730	36	10	lining	line	VERB
easat-2730	36	11	the	the	DET
easat-2730	36	12	blood	blood	NOUN
easat-2730	36	13	vessels	vessel	NOUN
easat-2730	36	14	,	,	PUNCT
easat-2730	36	15	that	that	PRON
easat-2730	36	16	establishes	establish	VERB
easat-2730	36	17	contact	contact	NOUN
easat-2730	36	18	between	between	ADP
easat-2730	36	19	the	the	DET
easat-2730	36	20	endothelial	endothelial	ADJ
easat-2730	36	21	lumen	luman	NOUN
easat-2730	36	22	and	and	CCONJ
easat-2730	36	23	the	the	DET
easat-2730	36	24	surrounding	surround	VERB
easat-2730	36	25	tissues	tissue	NOUN
easat-2730	36	26	[	[	X
easat-2730	36	27	10	10	NUM
easat-2730	36	28	]	]	PUNCT
easat-2730	36	29	.	.	PUNCT
easat-2730	37	1	the	the	DET
easat-2730	37	2	layer	layer	NOUN
easat-2730	37	3	is	be	AUX
easat-2730	37	4	surrounded	surround	VERB
easat-2730	37	5	by	by	ADP
easat-2730	37	6	the	the	DET
easat-2730	37	7	tunica	tunica	PROPN
easat-2730	37	8	intima	intima	NOUN
easat-2730	37	9	,	,	PUNCT
easat-2730	37	10	comprising	comprising	NOUN
easat-2730	37	11	of	of	ADP
easat-2730	37	12	endothelial	endothelial	ADJ
easat-2730	37	13	cells	cell	NOUN
easat-2730	37	14	,	,	PUNCT
easat-2730	37	15	the	the	DET
easat-2730	37	16	tunica	tunica	PROPN
easat-2730	37	17	media	medium	NOUN
easat-2730	37	18	,	,	PUNCT
easat-2730	37	19	which	which	PRON
easat-2730	37	20	contains	contain	VERB
easat-2730	37	21	vsmc	vsmc	NOUN
easat-2730	37	22	,	,	PUNCT
easat-2730	37	23	and	and	CCONJ
easat-2730	37	24	the	the	DET
easat-2730	37	25	elastic	elastic	PROPN
easat-2730	37	26	tunica	tunica	PROPN
easat-2730	37	27	adventitia	adventitia	PROPN
easat-2730	37	28	,	,	PUNCT
easat-2730	37	29	which	which	PRON
easat-2730	37	30	comprises	comprise	VERB
easat-2730	37	31	the	the	DET
easat-2730	37	32	terminal	terminal	ADJ
easat-2730	37	33	nerve	nerve	NOUN
easat-2730	37	34	fibres	fibre	NOUN
easat-2730	37	35	in	in	ADP
easat-2730	37	36	the	the	DET
easat-2730	37	37	connective	connective	ADJ
easat-2730	37	38	tissues	tissue	NOUN
easat-2730	37	39	.	.	PUNCT
easat-2730	38	1	physiologically	physiologically	ADV
easat-2730	38	2	,	,	PUNCT
easat-2730	38	3	the	the	DET
easat-2730	38	4	vascular	vascular	ADJ
easat-2730	38	5	endothelium	endothelium	NOUN
easat-2730	38	6	regulates	regulate	VERB
easat-2730	38	7	vascular	vascular	ADJ
easat-2730	38	8	homeostasis	homeostasis	NOUN
easat-2730	38	9	by	by	ADP
easat-2730	38	10	preserving	preserve	VERB
easat-2730	38	11	a	a	DET
easat-2730	38	12	stable	stable	ADJ
easat-2730	38	13	equilibrium	equilibrium	NOUN
easat-2730	38	14	between	between	ADP
easat-2730	38	15	the	the	DET
easat-2730	38	16	production	production	NOUN
easat-2730	38	17	of	of	ADP
easat-2730	38	18	vasodilators	vasodilator	NOUN
easat-2730	38	19	and	and	CCONJ
easat-2730	38	20	vasoconstrictors	vasoconstrictor	NOUN
easat-2730	38	21	,	,	PUNCT
easat-2730	38	22	oxidants	oxidant	NOUN
easat-2730	38	23	and	and	CCONJ
easat-2730	38	24	antioxidants	antioxidant	NOUN
easat-2730	38	25	,	,	PUNCT
easat-2730	38	26	prothrombotic	prothrombotic	ADJ
easat-2730	38	27	and	and	CCONJ
easat-2730	38	28	antithrombotic	antithrombotic	ADJ
easat-2730	38	29	factors	factor	NOUN
easat-2730	38	30	,	,	PUNCT
easat-2730	38	31	proinflammatory	proinflammatory	ADJ
easat-2730	38	32	and	and	CCONJ
easat-2730	38	33	anti	anti	ADJ
easat-2730	38	34	-	-	ADJ
easat-2730	38	35	inflammatory	inflammatory	ADJ
easat-2730	38	36	molecules	molecule	NOUN
easat-2730	38	37	[	[	X
easat-2730	38	38	4	4	NUM
easat-2730	38	39	]	]	PUNCT
easat-2730	38	40	,	,	PUNCT
easat-2730	38	41	constant	constant	ADJ
easat-2730	38	42	normal	normal	ADJ
easat-2730	38	43	blood	blood	NOUN
easat-2730	38	44	flow	flow	NOUN
easat-2730	38	45	,	,	PUNCT
easat-2730	38	46	circulation	circulation	NOUN
easat-2730	38	47	of	of	ADP
easat-2730	38	48	nutrients	nutrient	NOUN
easat-2730	38	49	and	and	CCONJ
easat-2730	38	50	hormones	hormone	NOUN
easat-2730	38	51	,	,	PUNCT
easat-2730	38	52	and	and	CCONJ
easat-2730	38	53	migration	migration	NOUN
easat-2730	38	54	and	and	CCONJ
easat-2730	38	55	proliferation	proliferation	NOUN
easat-2730	38	56	of	of	ADP
easat-2730	38	57	vsmc	vsmc	NOUN
easat-2730	38	58	[	[	X
easat-2730	38	59	10	10	NUM
easat-2730	38	60	]	]	PUNCT
easat-2730	38	61	.	.	PUNCT
easat-2730	39	1	it	it	PRON
easat-2730	39	2	regulates	regulate	VERB
easat-2730	39	3	the	the	DET
easat-2730	39	4	activities	activity	NOUN
easat-2730	39	5	of	of	ADP
easat-2730	39	6	coagulation	coagulation	NOUN
easat-2730	39	7	and	and	CCONJ
easat-2730	39	8	fibrinolysis	fibrinolysis	NOUN
easat-2730	39	9	,	,	PUNCT
easat-2730	39	10	lowers	lower	VERB
easat-2730	39	11	the	the	DET
easat-2730	39	12	vascular	vascular	ADJ
easat-2730	39	13	tone	tone	NOUN
easat-2730	39	14	,	,	PUNCT
easat-2730	39	15	controls	control	VERB
easat-2730	39	16	cellular	cellular	ADJ
easat-2730	39	17	and	and	CCONJ
easat-2730	39	18	vascular	vascular	ADJ
easat-2730	39	19	adhesions	adhesion	NOUN
easat-2730	39	20	,	,	PUNCT
easat-2730	39	21	suppresses	suppress	VERB
easat-2730	39	22	leukocyte	leukocyte	NOUN
easat-2730	39	23	adhesions	adhesion	NOUN
easat-2730	39	24	,	,	PUNCT
easat-2730	39	25	controls	control	VERB
easat-2730	39	26	inflammatory	inflammatory	ADJ
easat-2730	39	27	processes	process	NOUN
easat-2730	39	28	and	and	CCONJ
easat-2730	39	29	angiogenesis	angiogenesis	NOUN
easat-2730	39	30	(	(	PUNCT
easat-2730	39	31	fig	fig	NOUN
easat-2730	39	32	.	.	NOUN
easat-2730	40	1	1	1	NUM
easat-2730	40	2	)	)	PUNCT
easat-2730	41	1	[	[	X
easat-2730	41	2	6	6	NUM
easat-2730	41	3	]	]	PUNCT
easat-2730	41	4	.	.	PUNCT
easat-2730	42	1	additionally	additionally	ADV
easat-2730	42	2	,	,	PUNCT
easat-2730	42	3	it	it	PRON
easat-2730	42	4	regulates	regulate	VERB
easat-2730	42	5	haemostatic	haemostatic	ADJ
easat-2730	42	6	processes	process	NOUN
easat-2730	42	7	,	,	PUNCT
easat-2730	42	8	including	include	VERB
easat-2730	42	9	inhibiting	inhibit	VERB
easat-2730	42	10	the	the	DET
easat-2730	42	11	activation	activation	NOUN
easat-2730	42	12	,	,	PUNCT
easat-2730	42	13	adhesion	adhesion	NOUN
easat-2730	42	14	and	and	CCONJ
easat-2730	42	15	aggregation	aggregation	NOUN
easat-2730	42	16	of	of	ADP
easat-2730	42	17	platelet	platelet	NOUN
easat-2730	42	18	through	through	ADP
easat-2730	42	19	interactions	interaction	NOUN
easat-2730	42	20	with	with	ADP
easat-2730	42	21	prostacyclin	prostacyclin	PROPN
easat-2730	42	22	(	(	PUNCT
easat-2730	42	23	pcl	pcl	PROPN
easat-2730	42	24	)	)	PUNCT
easat-2730	42	25	and	and	CCONJ
easat-2730	42	26	no	no	INTJ
easat-2730	42	27	by	by	ADP
easat-2730	42	28	ecto	ecto	NOUN
easat-2730	42	29	-	-	ADJ
easat-2730	42	30	adenosine	adenosine	ADJ
easat-2730	42	31	diphosphate	diphosphate	NOUN
easat-2730	42	32	(	(	PUNCT
easat-2730	42	33	adp)-ases	adp)-ases	PROPN
easat-2730	42	34	,	,	PUNCT
easat-2730	42	35	von	von	PROPN
easat-2730	42	36	willebrand	willebrand	NOUN
easat-2730	42	37	factor	factor	NOUN
easat-2730	42	38	(	(	PUNCT
easat-2730	42	39	vwf	vwf	NOUN
easat-2730	42	40	)	)	PUNCT
easat-2730	42	41	,	,	PUNCT
easat-2730	42	42	thrombomodulin	thrombomodulin	PROPN
easat-2730	42	43	(	(	PUNCT
easat-2730	42	44	tm	tm	PROPN
easat-2730	42	45	)	)	PUNCT
easat-2730	42	46	,	,	PUNCT
easat-2730	42	47	anti	anti	ADJ
easat-2730	42	48	-	-	ADJ
easat-2730	42	49	thrombin	thrombin	ADJ
easat-2730	42	50	iii	iii	X
easat-2730	42	51	(	(	PUNCT
easat-2730	42	52	atiii	atiii	PROPN
easat-2730	42	53	)	)	PUNCT
easat-2730	42	54	,	,	PUNCT
easat-2730	42	55	tissue	tissue	NOUN
easat-2730	42	56	factor	factor	NOUN
easat-2730	42	57	(	(	PUNCT
easat-2730	42	58	tf	tf	PROPN
easat-2730	42	59	)	)	PUNCT
easat-2730	42	60	,	,	PUNCT
easat-2730	42	61	and	and	CCONJ
easat-2730	42	62	tissue	tissue	NOUN
easat-2730	42	63	factor	factor	NOUN
easat-2730	42	64	pathway	pathway	NOUN
easat-2730	42	65	inhibitor	inhibitor	NOUN
easat-2730	42	66	(	(	PUNCT
easat-2730	42	67	tfpi	tfpi	ADJ
easat-2730	42	68	)	)	PUNCT
easat-2730	42	69	,	,	PUNCT
easat-2730	42	70	along	along	ADP
easat-2730	42	71	with	with	ADP
easat-2730	42	72	cd39	cd39	PROPN
easat-2730	42	73	and	and	CCONJ
easat-2730	42	74	cd73	cd73	PROPN
easat-2730	42	75	exposures	exposure	NOUN
easat-2730	42	76	,	,	PUNCT
easat-2730	42	77	and	and	CCONJ
easat-2730	42	78	prostaglandin	prostaglandin	NOUN
easat-2730	42	79	e2	e2	NOUN
easat-2730	42	80	induced	induce	VERB
easat-2730	42	81	by	by	ADP
easat-2730	42	82	glycosaminoglycans	glycosaminoglycan	NOUN
easat-2730	42	83	on	on	ADP
easat-2730	42	84	the	the	DET
easat-2730	42	85	surface	surface	NOUN
easat-2730	42	86	of	of	ADP
easat-2730	42	87	endothelial	endothelial	ADJ
easat-2730	42	88	cells	cell	NOUN
easat-2730	42	89	(	(	PUNCT
easat-2730	42	90	tfpi	tfpi	ADJ
easat-2730	42	91	)	)	PUNCT
easat-2730	42	92	.	.	PUNCT
easat-2730	43	1	it	it	PRON
easat-2730	43	2	regulates	regulate	VERB
easat-2730	43	3	plasminogen	plasminogen	NOUN
easat-2730	43	4	activator	activator	NOUN
easat-2730	43	5	inhibitor-1	inhibitor-1	NUM
easat-2730	43	6	(	(	PUNCT
easat-2730	43	7	pai-1	pai-1	X
easat-2730	43	8	)	)	PUNCT
easat-2730	43	9	,	,	PUNCT
easat-2730	43	10	tissue	tissue	NOUN
easat-2730	43	11	-	-	PUNCT
easat-2730	43	12	type	type	NOUN
easat-2730	43	13	plasminogen	plasminogen	NOUN
easat-2730	43	14	activator	activator	NOUN
easat-2730	43	15	(	(	PUNCT
easat-2730	43	16	tpa	tpa	PROPN
easat-2730	43	17	)	)	PUNCT
easat-2730	43	18	,	,	PUNCT
easat-2730	43	19	urokinase	urokinase	NOUN
easat-2730	43	20	plasminogen	plasminogen	NOUN
easat-2730	43	21	activator	activator	NOUN
easat-2730	43	22	(	(	PUNCT
easat-2730	43	23	upa	upa	NOUN
easat-2730	43	24	)	)	PUNCT
easat-2730	43	25	)	)	PUNCT
easat-2730	44	1	[	[	X
easat-2730	44	2	11	11	NUM
easat-2730	44	3	]	]	PUNCT
easat-2730	44	4	.	.	PUNCT
easat-2730	45	1	through	through	ADP
easat-2730	45	2	its	its	PRON
easat-2730	45	3	paracrine	paracrine	NOUN
easat-2730	45	4	and	and	CCONJ
easat-2730	45	5	autocrine	autocrine	NOUN
easat-2730	45	6	activities	activity	NOUN
easat-2730	45	7	and	and	CCONJ
easat-2730	45	8	other	other	ADJ
easat-2730	45	9	range	range	NOUN
easat-2730	45	10	of	of	ADP
easat-2730	45	11	regulatory	regulatory	ADJ
easat-2730	45	12	mediators	mediator	NOUN
easat-2730	45	13	,	,	PUNCT
easat-2730	45	14	including	include	VERB
easat-2730	45	15	no	no	PRON
easat-2730	45	16	,	,	PUNCT
easat-2730	45	17	prostanoids	prostanoid	NOUN
easat-2730	45	18	,	,	PUNCT
easat-2730	45	19	endothelin-1	endothelin-1	PRON
easat-2730	45	20	(	(	PUNCT
easat-2730	45	21	et-1	et-1	X
easat-2730	45	22	)	)	PUNCT
easat-2730	45	23	,	,	PUNCT
easat-2730	45	24	angiotensin	angiotensin	NOUN
easat-2730	45	25	ii	ii	PROPN
easat-2730	45	26	(	(	PUNCT
easat-2730	45	27	ang	ang	PROPN
easat-2730	45	28	ii	ii	PROPN
easat-2730	45	29	)	)	PUNCT
easat-2730	45	30	,	,	PUNCT
easat-2730	45	31	t	t	PROPN
easat-2730	45	32	-	-	PUNCT
easat-2730	45	33	pa	pa	PROPN
easat-2730	45	34	,	,	PUNCT
easat-2730	45	35	pai-1	pai-1	X
easat-2730	45	36	,	,	PUNCT
easat-2730	45	37	vwf	vwf	NOUN
easat-2730	45	38	,	,	PUNCT
easat-2730	45	39	adhesion	adhesion	NOUN
easat-2730	45	40	molecules	molecule	NOUN
easat-2730	45	41	,	,	PUNCT
easat-2730	45	42	and	and	CCONJ
easat-2730	45	43	cytokines	cytokine	NOUN
easat-2730	45	44	that	that	PRON
easat-2730	45	45	have	have	AUX
easat-2730	45	46	been	be	AUX
easat-2730	45	47	activated	activate	VERB
easat-2730	45	48	in	in	ADP
easat-2730	45	49	response	response	NOUN
easat-2730	45	50	to	to	ADP
easat-2730	45	51	various	various	ADJ
easat-2730	45	52	stimuli	stimulus	NOUN
easat-2730	45	53	,	,	PUNCT
easat-2730	45	54	the	the	DET
easat-2730	45	55	endothelium	endothelium	NOUN
easat-2730	45	56	produces	produce	VERB
easat-2730	45	57	endothelial	endothelial	ADJ
easat-2730	45	58	cell	cell	NOUN
easat-2730	45	59	moieties	moiety	NOUN
easat-2730	45	60	,	,	PUNCT
easat-2730	45	61	to	to	PART
easat-2730	45	62	render	render	VERB
easat-2730	45	63	its	its	PRON
easat-2730	45	64	normal	normal	ADJ
easat-2730	45	65	functions	function	NOUN
easat-2730	45	66	.	.	PUNCT
easat-2730	46	1	[	[	X
easat-2730	46	2	2,3,4	2,3,4	NUM
easat-2730	46	3	]	]	X
easat-2730	46	4	.	.	PUNCT
easat-2730	46	5	3443	3443	NUM
easat-2730	46	6	edelweiss	edelweiss	PROPN
easat-2730	46	7	applied	apply	VERB
easat-2730	46	8	science	science	NOUN
easat-2730	46	9	and	and	CCONJ
easat-2730	46	10	technology	technology	NOUN
easat-2730	46	11	issn	issn	PROPN
easat-2730	46	12	:	:	PUNCT
easat-2730	46	13	2576	2576	NUM
easat-2730	46	14	-	-	SYM
easat-2730	46	15	8484	8484	NUM
easat-2730	46	16	vol	vol	NOUN
easat-2730	46	17	.	.	PROPN
easat-2730	46	18	8	8	NUM
easat-2730	46	19	,	,	PUNCT
easat-2730	46	20	no	no	INTJ
easat-2730	46	21	.	.	NOUN
easat-2730	47	1	6	6	NUM
easat-2730	47	2	:	:	SYM
easat-2730	47	3	3441	3441	NUM
easat-2730	47	4	-	-	SYM
easat-2730	47	5	3456	3456	NUM
easat-2730	47	6	,	,	PUNCT
easat-2730	47	7	2024	2024	NUM
easat-2730	47	8	doi	doi	NOUN
easat-2730	47	9	:	:	PUNCT
easat-2730	47	10	10.55214/25768484.v8i6.2730	10.55214/25768484.v8i6.2730	NUM
easat-2730	47	11	©	©	ADP
easat-2730	47	12	2024	2024	NUM
easat-2730	47	13	by	by	ADP
easat-2730	47	14	the	the	DET
easat-2730	47	15	authors	author	NOUN
easat-2730	47	16	;	;	PUNCT
easat-2730	47	17	licensee	licensee	PROPN
easat-2730	47	18	learning	learning	NOUN
easat-2730	47	19	gate	gate	VERB
easat-2730	47	20	the	the	DET
easat-2730	47	21	secretions	secretion	NOUN
easat-2730	47	22	of	of	ADP
easat-2730	47	23	tm	tm	NOUN
easat-2730	47	24	,	,	PUNCT
easat-2730	47	25	heparin	heparin	ADJ
easat-2730	47	26	sulphate	sulphate	NOUN
easat-2730	47	27	proteoglycan	proteoglycan	NOUN
easat-2730	47	28	(	(	PUNCT
easat-2730	47	29	hspg	hspg	PROPN
easat-2730	47	30	)	)	PUNCT
easat-2730	47	31	,	,	PUNCT
easat-2730	47	32	and	and	CCONJ
easat-2730	47	33	tfpi	tfpi	VERB
easat-2730	47	34	are	be	AUX
easat-2730	47	35	linked	link	VERB
easat-2730	47	36	to	to	ADP
easat-2730	47	37	endothelial	endothelial	ADJ
easat-2730	47	38	anticoagulant	anticoagulant	ADJ
easat-2730	47	39	activities	activity	NOUN
easat-2730	47	40	.	.	PUNCT
easat-2730	48	1	when	when	SCONJ
easat-2730	48	2	protein	protein	NOUN
easat-2730	48	3	c	c	PROPN
easat-2730	48	4	is	be	AUX
easat-2730	48	5	activated	activate	VERB
easat-2730	48	6	by	by	ADP
easat-2730	48	7	the	the	DET
easat-2730	48	8	interaction	interaction	NOUN
easat-2730	48	9	of	of	ADP
easat-2730	48	10	tm	tm	PROPN
easat-2730	48	11	and	and	CCONJ
easat-2730	48	12	thrombin	thrombin	NOUN
easat-2730	48	13	,	,	PUNCT
easat-2730	48	14	both	both	DET
easat-2730	48	15	fviii	fviii	NOUN
easat-2730	48	16	and	and	CCONJ
easat-2730	48	17	fv	fv	NUM
easat-2730	48	18	activites	activite	NOUN
easat-2730	48	19	are	be	AUX
easat-2730	48	20	subsequently	subsequently	ADV
easat-2730	48	21	suppressed	suppress	VERB
easat-2730	48	22	.	.	PUNCT
easat-2730	49	1	the	the	DET
easat-2730	49	2	tm	tm	PROPN
easat-2730	49	3	is	be	AUX
easat-2730	49	4	a	a	DET
easat-2730	49	5	heparin	heparin	NOUN
easat-2730	49	6	-	-	PUNCT
easat-2730	49	7	like	like	ADJ
easat-2730	49	8	molecule	molecule	NOUN
easat-2730	49	9	that	that	PRON
easat-2730	49	10	acts	act	VERB
easat-2730	49	11	as	as	ADP
easat-2730	49	12	a	a	DET
easat-2730	49	13	co	co	NOUN
easat-2730	49	14	-	-	NOUN
easat-2730	49	15	factor	factor	NOUN
easat-2730	49	16	to	to	PART
easat-2730	49	17	atiii	atiii	VERB
easat-2730	49	18	,	,	PUNCT
easat-2730	49	19	while	while	SCONJ
easat-2730	49	20	the	the	DET
easat-2730	49	21	fxa	fxa	NOUN
easat-2730	49	22	and	and	CCONJ
easat-2730	49	23	tf	tf	ADJ
easat-2730	49	24	-	-	PUNCT
easat-2730	49	25	fviia	fviia	NOUN
easat-2730	49	26	complex	complex	ADJ
easat-2730	49	27	activities	activity	NOUN
easat-2730	49	28	are	be	AUX
easat-2730	49	29	attenuated	attenuate	VERB
easat-2730	49	30	by	by	ADP
easat-2730	49	31	tfpi	tfpi	ADJ
easat-2730	49	32	.	.	PUNCT
easat-2730	50	1	endothelial	endothelial	PROPN
easat-2730	50	2	t	t	PROPN
easat-2730	50	3	-	-	PUNCT
easat-2730	50	4	pa	pa	PROPN
easat-2730	50	5	improves	improve	VERB
easat-2730	50	6	the	the	DET
easat-2730	50	7	fibrinolytic	fibrinolytic	ADJ
easat-2730	50	8	system	system	NOUN
easat-2730	50	9	,	,	PUNCT
easat-2730	50	10	while	while	SCONJ
easat-2730	50	11	pcl	pcl	PROPN
easat-2730	50	12	and	and	CCONJ
easat-2730	50	13	no	no	PROPN
easat-2730	50	14	are	be	AUX
easat-2730	50	15	produced	produce	VERB
easat-2730	50	16	to	to	PART
easat-2730	50	17	maintain	maintain	VERB
easat-2730	50	18	endothelial	endothelial	ADJ
easat-2730	50	19	antiplatelet	antiplatelet	NOUN
easat-2730	50	20	properties	property	NOUN
easat-2730	50	21	[	[	X
easat-2730	50	22	12	12	NUM
easat-2730	50	23	]	]	PUNCT
easat-2730	50	24	.	.	PUNCT
easat-2730	51	1	no	no	PRON
easat-2730	51	2	is	be	AUX
easat-2730	51	3	unquestionably	unquestionably	ADV
easat-2730	51	4	recognised	recognise	VERB
easat-2730	51	5	to	to	PART
easat-2730	51	6	achieve	achieve	VERB
easat-2730	51	7	a	a	DET
easat-2730	51	8	significant	significant	ADJ
easat-2730	51	9	role	role	NOUN
easat-2730	51	10	in	in	ADP
easat-2730	51	11	maintaining	maintain	VERB
easat-2730	51	12	normal	normal	ADJ
easat-2730	51	13	vascular	vascular	ADJ
easat-2730	51	14	endothelium	endothelium	NOUN
easat-2730	51	15	through	through	ADP
easat-2730	51	16	various	various	ADJ
easat-2730	51	17	ways	way	NOUN
easat-2730	51	18	,	,	PUNCT
easat-2730	51	19	such	such	ADJ
easat-2730	51	20	as	as	ADP
easat-2730	51	21	inhibiting	inhibit	VERB
easat-2730	51	22	platelet	platelet	NOUN
easat-2730	51	23	aggregation	aggregation	NOUN
easat-2730	51	24	,	,	PUNCT
easat-2730	51	25	monocyte	monocyte	NOUN
easat-2730	51	26	adherence	adherence	NOUN
easat-2730	51	27	to	to	ADP
easat-2730	51	28	endothelial	endothelial	ADJ
easat-2730	51	29	cells	cell	NOUN
easat-2730	51	30	,	,	PUNCT
easat-2730	51	31	and	and	CCONJ
easat-2730	51	32	aberrant	aberrant	ADJ
easat-2730	51	33	vsmc	vsmc	NOUN
easat-2730	51	34	proliferation	proliferation	NOUN
easat-2730	51	35	[	[	X
easat-2730	51	36	13	13	NUM
easat-2730	51	37	]	]	PUNCT
easat-2730	51	38	.	.	PUNCT
easat-2730	52	1	endothelial	endothelial	ADJ
easat-2730	52	2	nitric	nitric	ADJ
easat-2730	52	3	oxide	oxide	NOUN
easat-2730	52	4	synthase	synthase	NOUN
easat-2730	52	5	(	(	PUNCT
easat-2730	52	6	enos	enos	PROPN
easat-2730	52	7	)	)	PUNCT
easat-2730	52	8	converts	convert	VERB
easat-2730	52	9	l	l	NOUN
easat-2730	52	10	-	-	NOUN
easat-2730	52	11	arginine	arginine	NOUN
easat-2730	52	12	to	to	ADP
easat-2730	52	13	no	no	PRON
easat-2730	52	14	in	in	ADP
easat-2730	52	15	the	the	DET
easat-2730	52	16	presence	presence	NOUN
easat-2730	52	17	of	of	ADP
easat-2730	52	18	cofactors	cofactor	NOUN
easat-2730	52	19	such	such	ADJ
easat-2730	52	20	tetrahydrobiopterin	tetrahydrobiopterin	NOUN
easat-2730	52	21	.	.	PUNCT
easat-2730	53	1	when	when	SCONJ
easat-2730	53	2	no	no	PRON
easat-2730	53	3	is	be	AUX
easat-2730	53	4	produced	produce	VERB
easat-2730	53	5	,	,	PUNCT
easat-2730	53	6	it	it	PRON
easat-2730	53	7	diffuses	diffuse	VERB
easat-2730	53	8	to	to	ADP
easat-2730	53	9	the	the	DET
easat-2730	53	10	vsmc	vsmc	NOUN
easat-2730	53	11	and	and	CCONJ
easat-2730	53	12	enhances	enhance	VERB
easat-2730	53	13	guanylate	guanylate	NOUN
easat-2730	53	14	cyclase	cyclase	NOUN
easat-2730	53	15	,	,	PUNCT
easat-2730	53	16	which	which	PRON
easat-2730	53	17	causes	cause	VERB
easat-2730	53	18	vasodilation	vasodilation	NOUN
easat-2730	53	19	mediated	mediate	VERB
easat-2730	53	20	by	by	ADP
easat-2730	53	21	cyclic	cyclic	PROPN
easat-2730	53	22	guanosine	guanosine	NOUN
easat-2730	53	23	monophosphate	monophosphate	NOUN
easat-2730	53	24	(	(	PUNCT
easat-2730	53	25	cgmp	cgmp	PROPN
easat-2730	53	26	)	)	PUNCT
easat-2730	53	27	(	(	PUNCT
easat-2730	53	28	fig	fig	NOUN
easat-2730	53	29	.	.	PUNCT
easat-2730	54	1	1	1	NUM
easat-2730	54	2	)	)	PUNCT
easat-2730	54	3	.	.	PUNCT
easat-2730	55	1	additionally	additionally	ADV
easat-2730	55	2	,	,	PUNCT
easat-2730	55	3	no	no	INTJ
easat-2730	55	4	is	be	AUX
easat-2730	55	5	linked	link	VERB
easat-2730	55	6	to	to	ADP
easat-2730	55	7	various	various	ADJ
easat-2730	55	8	endothelium	endothelium	NOUN
easat-2730	55	9	-	-	PUNCT
easat-2730	55	10	protective	protective	ADJ
easat-2730	55	11	processes	process	NOUN
easat-2730	55	12	,	,	PUNCT
easat-2730	55	13	such	such	ADJ
easat-2730	55	14	as	as	ADP
easat-2730	55	15	the	the	DET
easat-2730	55	16	suppression	suppression	NOUN
easat-2730	55	17	of	of	ADP
easat-2730	55	18	vascular	vascular	ADJ
easat-2730	55	19	inflammation	inflammation	NOUN
easat-2730	55	20	,	,	PUNCT
easat-2730	55	21	growth	growth	NOUN
easat-2730	55	22	of	of	ADP
easat-2730	55	23	vsmc	vsmc	NOUN
easat-2730	55	24	,	,	PUNCT
easat-2730	55	25	platelet	platelet	NOUN
easat-2730	55	26	aggregation	aggregation	NOUN
easat-2730	55	27	,	,	PUNCT
easat-2730	55	28	and	and	CCONJ
easat-2730	55	29	the	the	DET
easat-2730	55	30	release	release	NOUN
easat-2730	55	31	of	of	ADP
easat-2730	55	32	tissue	tissue	NOUN
easat-2730	55	33	factors	factor	NOUN
easat-2730	55	34	[	[	X
easat-2730	55	35	3	3	NUM
easat-2730	55	36	]	]	PUNCT
easat-2730	55	37	.	.	PUNCT
easat-2730	56	1	hence	hence	ADV
easat-2730	56	2	modifications	modification	NOUN
easat-2730	56	3	to	to	ADP
easat-2730	56	4	the	the	DET
easat-2730	56	5	regular	regular	ADJ
easat-2730	56	6	endothelial	endothelial	ADJ
easat-2730	56	7	physiology	physiology	NOUN
easat-2730	56	8	might	might	AUX
easat-2730	56	9	lead	lead	VERB
easat-2730	56	10	to	to	ADP
easat-2730	56	11	endothelial	endothelial	ADJ
easat-2730	56	12	dysfunction	dysfunction	NOUN
easat-2730	56	13	,	,	PUNCT
easat-2730	56	14	associated	associate	VERB
easat-2730	56	15	with	with	ADP
easat-2730	56	16	a	a	DET
easat-2730	56	17	reduction	reduction	NOUN
easat-2730	56	18	in	in	ADP
easat-2730	56	19	the	the	DET
easat-2730	56	20	bioavailability	bioavailability	NOUN
easat-2730	56	21	of	of	ADP
easat-2730	56	22	vasodilators	vasodilator	NOUN
easat-2730	56	23	,	,	PUNCT
easat-2730	56	24	particularly	particularly	ADV
easat-2730	56	25	the	the	DET
easat-2730	56	26	no	no	NOUN
easat-2730	57	1	[	[	X
easat-2730	57	2	13	13	NUM
easat-2730	57	3	]	]	PUNCT
easat-2730	57	4	.	.	PUNCT
easat-2730	58	1	figure	figure	NOUN
easat-2730	58	2	1	1	NUM
easat-2730	58	3	.	.	PUNCT
easat-2730	59	1	some	some	DET
easat-2730	59	2	protective	protective	ADJ
easat-2730	59	3	functions	function	NOUN
easat-2730	59	4	of	of	ADP
easat-2730	59	5	the	the	DET
easat-2730	59	6	normal	normal	ADJ
easat-2730	59	7	vascular	vascular	ADJ
easat-2730	59	8	endothelium	endothelium	NOUN
easat-2730	59	9	.	.	PUNCT
easat-2730	60	1	t	t	PROPN
easat-2730	60	2	-	-	PUNCT
easat-2730	60	3	pa	pa	PROPN
easat-2730	60	4	;	;	PUNCT
easat-2730	60	5	tissue	tissue	NOUN
easat-2730	60	6	-	-	PUNCT
easat-2730	60	7	type	type	NOUN
easat-2730	60	8	plasminogen	plasminogen	NOUN
easat-2730	60	9	activator	activator	NOUN
easat-2730	60	10	,	,	PUNCT
easat-2730	60	11	u	u	NOUN
easat-2730	60	12	-	-	PROPN
easat-2730	60	13	pa	pa	NOUN
easat-2730	60	14	;	;	PUNCT
easat-2730	60	15	urokinase	urokinase	VERB
easat-2730	60	16	plasminogen	plasminogen	NOUN
easat-2730	60	17	activator	activator	NOUN
easat-2730	60	18	,	,	PUNCT
easat-2730	60	19	adp	adp	PROPN
easat-2730	60	20	;	;	PUNCT
easat-2730	60	21	adenosine	adenosine	ADJ
easat-2730	60	22	diphosphate	diphosphate	PROPN
easat-2730	60	23	,	,	PUNCT
easat-2730	60	24	atiii	atiii	VERB
easat-2730	60	25	;	;	PUNCT
easat-2730	60	26	antithrombin	antithrombin	PROPN
easat-2730	60	27	iii	iii	PROPN
easat-2730	60	28	,	,	PUNCT
easat-2730	60	29	tfpi	tfpi	VERB
easat-2730	60	30	;	;	PUNCT
easat-2730	60	31	tissue	tissue	NOUN
easat-2730	60	32	factor	factor	NOUN
easat-2730	60	33	pathway	pathway	NOUN
easat-2730	60	34	inhibitor	inhibitor	NOUN
easat-2730	60	35	,	,	PUNCT
easat-2730	60	36	fxa	fxa	NOUN
easat-2730	60	37	;	;	PUNCT
easat-2730	60	38	factor	factor	NOUN
easat-2730	60	39	x	x	PUNCT
easat-2730	60	40	activated	activate	VERB
easat-2730	60	41	,	,	PUNCT
easat-2730	60	42	no	no	INTJ
easat-2730	60	43	;	;	PUNCT
easat-2730	60	44	nitric	nitric	ADJ
easat-2730	60	45	oxide	oxide	NOUN
easat-2730	60	46	,	,	PUNCT
easat-2730	60	47	pgi2	pgi2	PROPN
easat-2730	60	48	;	;	PUNCT
easat-2730	60	49	prostacyclin	prostacyclin	ADJ
easat-2730	60	50	,	,	PUNCT
easat-2730	60	51	bh4	bh4	NOUN
easat-2730	60	52	;	;	PUNCT
easat-2730	60	53	tetrabiopterin	tetrabiopterin	NOUN
easat-2730	60	54	.	.	PUNCT
easat-2730	61	1	2.1	2.1	NUM
easat-2730	61	2	.	.	PUNCT
easat-2730	61	3	mechanisms	mechanism	NOUN
easat-2730	61	4	of	of	ADP
easat-2730	61	5	obesity	obesity	NOUN
easat-2730	61	6	-	-	PUNCT
easat-2730	61	7	induced	induce	VERB
easat-2730	61	8	endothelial	endothelial	ADJ
easat-2730	61	9	dysfunction	dysfunction	NOUN
easat-2730	61	10	the	the	DET
easat-2730	61	11	endothelium	endothelium	NOUN
easat-2730	61	12	is	be	AUX
easat-2730	61	13	an	an	DET
easat-2730	61	14	extremely	extremely	ADV
easat-2730	61	15	dynamic	dynamic	ADJ
easat-2730	61	16	tissue	tissue	NOUN
easat-2730	61	17	that	that	PRON
easat-2730	61	18	serves	serve	VERB
easat-2730	61	19	several	several	ADJ
easat-2730	61	20	essential	essential	ADJ
easat-2730	61	21	activities	activity	NOUN
easat-2730	61	22	,	,	PUNCT
easat-2730	61	23	which	which	PRON
easat-2730	61	24	differ	differ	VERB
easat-2730	61	25	from	from	ADP
easat-2730	61	26	one	one	NUM
easat-2730	61	27	vessel	vessel	NOUN
easat-2730	61	28	segment	segment	NOUN
easat-2730	61	29	to	to	ADP
easat-2730	61	30	another	another	PRON
easat-2730	61	31	and	and	CCONJ
easat-2730	61	32	from	from	ADP
easat-2730	61	33	one	one	NUM
easat-2730	61	34	system	system	NOUN
easat-2730	61	35	to	to	ADP
easat-2730	61	36	another	another	PRON
easat-2730	61	37	.	.	PUNCT
easat-2730	62	1	the	the	DET
easat-2730	62	2	vascular	vascular	ADJ
easat-2730	62	3	endothelium	endothelium	NOUN
easat-2730	62	4	secretes	secrete	NOUN
easat-2730	62	5	molecules	molecule	NOUN
easat-2730	62	6	which	which	PRON
easat-2730	62	7	control	control	VERB
easat-2730	62	8	the	the	DET
easat-2730	62	9	functions	function	NOUN
easat-2730	62	10	and	and	CCONJ
easat-2730	62	11	vascular	vascular	ADJ
easat-2730	62	12	network	network	NOUN
easat-2730	62	13	in	in	ADP
easat-2730	62	14	an	an	DET
easat-2730	62	15	autocrine	autocrine	NOUN
easat-2730	62	16	and	and	CCONJ
easat-2730	62	17	paracrine	paracrine	NOUN
easat-2730	62	18	manner	manner	NOUN
easat-2730	62	19	[	[	X
easat-2730	62	20	4	4	NUM
easat-2730	62	21	]	]	PUNCT
easat-2730	62	22	.	.	PUNCT
easat-2730	63	1	under	under	ADP
easat-2730	63	2	normal	normal	ADJ
easat-2730	63	3	physiology	physiology	NOUN
easat-2730	63	4	,	,	PUNCT
easat-2730	63	5	endothelium	endothelium	NOUN
easat-2730	63	6	functions	function	NOUN
easat-2730	63	7	to	to	PART
easat-2730	63	8	maintain	maintain	VERB
easat-2730	63	9	a	a	DET
easat-2730	63	10	balance	balance	NOUN
easat-2730	63	11	between	between	ADP
easat-2730	63	12	oxidants	oxidant	NOUN
easat-2730	63	13	and	and	CCONJ
easat-2730	63	14	antioxidants	antioxidant	NOUN
easat-2730	63	15	,	,	PUNCT
easat-2730	63	16	vasodilators	vasodilator	NOUN
easat-2730	63	17	and	and	CCONJ
easat-2730	63	18	vasoconstrictors	vasoconstrictor	NOUN
easat-2730	63	19	,	,	PUNCT
easat-2730	63	20	proinflammatory	proinflammatory	ADJ
easat-2730	63	21	and	and	CCONJ
easat-2730	63	22	anti	anti	ADJ
easat-2730	63	23	-	-	ADJ
easat-2730	63	24	inflammatory	inflammatory	ADJ
easat-2730	63	25	molecules	molecule	NOUN
easat-2730	63	26	,	,	PUNCT
easat-2730	63	27	prothrombotic	prothrombotic	ADJ
easat-2730	63	28	and	and	CCONJ
easat-2730	63	29	antithrombotic	antithrombotic	ADJ
easat-2730	63	30	signals	signal	NOUN
easat-2730	63	31	and	and	CCONJ
easat-2730	63	32	secretion	secretion	NOUN
easat-2730	63	33	of	of	ADP
easat-2730	63	34	endothelial	endothelial	NOUN
easat-2730	63	35	-	-	PUNCT
easat-2730	63	36	derived	derive	VERB
easat-2730	63	37	vasodilating	vasodilate	VERB
easat-2730	63	38	and	and	CCONJ
easat-2730	63	39	vasoconstricting	vasoconstricte	VERB
easat-2730	63	40	factors	factor	NOUN
easat-2730	63	41	.	.	PUNCT
easat-2730	64	1	however	however	ADV
easat-2730	64	2	,	,	PUNCT
easat-2730	64	3	in	in	ADP
easat-2730	64	4	obesity	obesity	NOUN
easat-2730	64	5	the	the	DET
easat-2730	64	6	endothelium	endothelium	NOUN
easat-2730	64	7	could	could	AUX
easat-2730	64	8	lost	lose	VERB
easat-2730	64	9	this	this	DET
easat-2730	64	10	tightly	tightly	ADV
easat-2730	64	11	controlled	control	VERB
easat-2730	64	12	equilibrium	equilibrium	NOUN
easat-2730	64	13	and	and	CCONJ
easat-2730	64	14	exhibits	exhibit	VERB
easat-2730	64	15	oxidant	oxidant	NOUN
easat-2730	64	16	,	,	PUNCT
easat-2730	64	17	vasoconstrictor	vasoconstrictor	NOUN
easat-2730	64	18	,	,	PUNCT
easat-2730	64	19	proinflammatory	proinflammatory	NOUN
easat-2730	64	20	,	,	PUNCT
easat-2730	64	21	proatherogenic	proatherogenic	ADJ
easat-2730	64	22	,	,	PUNCT
easat-2730	64	23	and	and	CCONJ
easat-2730	64	24	prothrombotic	prothrombotic	ADJ
easat-2730	64	25	properties	property	NOUN
easat-2730	64	26	,	,	PUNCT
easat-2730	64	27	which	which	PRON
easat-2730	64	28	promotes	promote	VERB
easat-2730	64	29	the	the	DET
easat-2730	64	30	progression	progression	NOUN
easat-2730	64	31	and	and	CCONJ
easat-2730	64	32	development	development	NOUN
easat-2730	64	33	of	of	ADP
easat-2730	64	34	vascular	vascular	ADJ
easat-2730	64	35	endothelial	endothelial	ADJ
easat-2730	64	36	dysfunction	dysfunction	NOUN
easat-2730	64	37	and	and	CCONJ
easat-2730	64	38	end	end	NOUN
easat-2730	64	39	-	-	PUNCT
easat-2730	64	40	organ	organ	NOUN
easat-2730	64	41	damage	damage	NOUN
easat-2730	64	42	[	[	X
easat-2730	64	43	1	1	NUM
easat-2730	64	44	,	,	PUNCT
easat-2730	64	45	13	13	NUM
easat-2730	64	46	]	]	PUNCT
easat-2730	64	47	.	.	PUNCT
easat-2730	65	1	a	a	DET
easat-2730	65	2	dysfunctional	dysfunctional	ADJ
easat-2730	65	3	endothelium	endothelium	NOUN
easat-2730	65	4	is	be	AUX
easat-2730	65	5	associated	associate	VERB
easat-2730	65	6	with	with	ADP
easat-2730	65	7	leukocyte	leukocyte	NOUN
easat-2730	65	8	adhesion	adhesion	NOUN
easat-2730	65	9	,	,	PUNCT
easat-2730	65	10	platelet	platelet	NOUN
easat-2730	65	11	activation	activation	NOUN
easat-2730	65	12	,	,	PUNCT
easat-2730	65	13	prooxidation	prooxidation	NOUN
easat-2730	65	14	of	of	ADP
easat-2730	65	15	mitogens	mitogen	NOUN
easat-2730	65	16	,	,	PUNCT
easat-2730	65	17	impaired	impaired	ADJ
easat-2730	65	18	pgi2	pgi2	NOUN
easat-2730	65	19	,	,	PUNCT
easat-2730	65	20	coagulation	coagulation	NOUN
easat-2730	65	21	,	,	PUNCT
easat-2730	65	22	decreased	decrease	VERB
easat-2730	65	23	no	no	DET
easat-2730	65	24	synthesis	synthesis	NOUN
easat-2730	65	25	and	and	CCONJ
easat-2730	65	26	released	release	VERB
easat-2730	65	27	,	,	PUNCT
easat-2730	65	28	decreased	decrease	VERB
easat-2730	65	29	secretion	secretion	NOUN
easat-2730	65	30	of	of	ADP
easat-2730	65	31	edhf	edhf	ADJ
easat-2730	65	32	and	and	CCONJ
easat-2730	65	33	vasoconstriction	vasoconstriction	NOUN
easat-2730	65	34	factors	factor	NOUN
easat-2730	65	35	,	,	PUNCT
easat-2730	65	36	such	such	ADJ
easat-2730	65	37	as	as	ADP
easat-2730	65	38	ang	ang	PROPN
easat-2730	65	39	ii	ii	PROPN
easat-2730	65	40	and	and	CCONJ
easat-2730	65	41	prostaglandin	prostaglandin	NOUN
easat-2730	65	42	(	(	PUNCT
easat-2730	65	43	pgh2	pgh2	PROPN
easat-2730	65	44	)	)	PUNCT
easat-2730	65	45	,	,	PUNCT
easat-2730	65	46	as	as	ADV
easat-2730	65	47	well	well	ADV
easat-2730	65	48	as	as	ADP
easat-2730	65	49	atherosclerosis	atherosclerosis	NOUN
easat-2730	65	50	and	and	CCONJ
easat-2730	65	51	thrombosis	thrombosis	NOUN
easat-2730	66	1	[	[	X
easat-2730	66	2	14	14	NUM
easat-2730	66	3	]	]	PUNCT
easat-2730	66	4	.	.	PUNCT
easat-2730	67	1	the	the	DET
easat-2730	67	2	development	development	NOUN
easat-2730	67	3	of	of	ADP
easat-2730	67	4	vascular	vascular	ADJ
easat-2730	67	5	diseases	disease	NOUN
easat-2730	67	6	starts	start	VERB
easat-2730	67	7	with	with	ADP
easat-2730	67	8	endothelial	endothelial	ADJ
easat-2730	67	9	3444	3444	NUM
easat-2730	67	10	edelweiss	edelweiss	PROPN
easat-2730	67	11	applied	apply	VERB
easat-2730	67	12	science	science	NOUN
easat-2730	67	13	and	and	CCONJ
easat-2730	67	14	technology	technology	NOUN
easat-2730	67	15	issn	issn	PROPN
easat-2730	67	16	:	:	PUNCT
easat-2730	67	17	2576	2576	NUM
easat-2730	67	18	-	-	SYM
easat-2730	67	19	8484	8484	NUM
easat-2730	67	20	vol	vol	NOUN
easat-2730	67	21	.	.	PROPN
easat-2730	67	22	8	8	NUM
easat-2730	67	23	,	,	PUNCT
easat-2730	67	24	no	no	INTJ
easat-2730	67	25	.	.	NOUN
easat-2730	67	26	6	6	NUM
easat-2730	67	27	:	:	SYM
easat-2730	67	28	3441	3441	NUM
easat-2730	67	29	-	-	SYM
easat-2730	67	30	3456	3456	NUM
easat-2730	67	31	,	,	PUNCT
easat-2730	67	32	2024	2024	NUM
easat-2730	67	33	doi	doi	NOUN
easat-2730	67	34	:	:	PUNCT
easat-2730	67	35	10.55214/25768484.v8i6.2730	10.55214/25768484.v8i6.2730	NUM
easat-2730	67	36	©	©	ADP
easat-2730	67	37	2024	2024	NUM
easat-2730	67	38	by	by	ADP
easat-2730	67	39	the	the	DET
easat-2730	67	40	authors	author	NOUN
easat-2730	67	41	;	;	PUNCT
easat-2730	67	42	licensee	licensee	NOUN
easat-2730	67	43	learning	learning	NOUN
easat-2730	67	44	gate	gate	NOUN
easat-2730	67	45	dysfunction	dysfunction	NOUN
easat-2730	67	46	,	,	PUNCT
easat-2730	67	47	which	which	PRON
easat-2730	67	48	has	have	VERB
easat-2730	67	49	negative	negative	ADJ
easat-2730	67	50	impacts	impact	NOUN
easat-2730	67	51	on	on	ADP
easat-2730	67	52	other	other	ADJ
easat-2730	67	53	vascular	vascular	ADJ
easat-2730	67	54	cells	cell	NOUN
easat-2730	67	55	,	,	PUNCT
easat-2730	67	56	such	such	ADJ
easat-2730	67	57	as	as	ADP
easat-2730	67	58	vsmc	vsmc	NOUN
easat-2730	67	59	and	and	CCONJ
easat-2730	67	60	immune	immune	ADJ
easat-2730	67	61	cells	cell	NOUN
easat-2730	67	62	,	,	PUNCT
easat-2730	67	63	which	which	PRON
easat-2730	67	64	may	may	AUX
easat-2730	67	65	ultimately	ultimately	ADV
easat-2730	67	66	result	result	VERB
easat-2730	67	67	in	in	ADP
easat-2730	67	68	vascular	vascular	ADJ
easat-2730	67	69	failure	failure	NOUN
easat-2730	67	70	.	.	PUNCT
easat-2730	68	1	inflammation	inflammation	NOUN
easat-2730	68	2	is	be	AUX
easat-2730	68	3	a	a	DET
easat-2730	68	4	term	term	NOUN
easat-2730	68	5	associated	associate	VERB
easat-2730	68	6	with	with	ADP
easat-2730	68	7	oedema	oedema	NOUN
easat-2730	68	8	,	,	PUNCT
easat-2730	68	9	transmigration	transmigration	NOUN
easat-2730	68	10	and	and	CCONJ
easat-2730	68	11	infiltration	infiltration	NOUN
easat-2730	68	12	of	of	ADP
easat-2730	68	13	leukocytes	leukocyte	NOUN
easat-2730	68	14	,	,	PUNCT
easat-2730	68	15	blood	blood	NOUN
easat-2730	68	16	vessel	vessel	NOUN
easat-2730	68	17	and	and	CCONJ
easat-2730	68	18	connective	connective	ADJ
easat-2730	68	19	tissue	tissue	NOUN
easat-2730	68	20	proliferation	proliferation	NOUN
easat-2730	68	21	.	.	PUNCT
easat-2730	69	1	inflammation	inflammation	NOUN
easat-2730	69	2	is	be	AUX
easat-2730	69	3	recognised	recognise	VERB
easat-2730	69	4	as	as	ADP
easat-2730	69	5	the	the	DET
easat-2730	69	6	first	first	ADJ
easat-2730	69	7	stage	stage	NOUN
easat-2730	69	8	of	of	ADP
easat-2730	69	9	vascular	vascular	ADJ
easat-2730	69	10	dysfunction	dysfunction	NOUN
easat-2730	69	11	[	[	X
easat-2730	69	12	4	4	NUM
easat-2730	69	13	,	,	PUNCT
easat-2730	69	14	14	14	NUM
easat-2730	69	15	]	]	PUNCT
easat-2730	69	16	.	.	PUNCT
easat-2730	70	1	several	several	ADJ
easat-2730	70	2	fundamental	fundamental	ADJ
easat-2730	70	3	mechanisms	mechanism	NOUN
easat-2730	70	4	,	,	PUNCT
easat-2730	70	5	such	such	ADJ
easat-2730	70	6	as	as	ADP
easat-2730	70	7	increased	increase	VERB
easat-2730	70	8	concentrations	concentration	NOUN
easat-2730	70	9	of	of	ADP
easat-2730	70	10	ldl	ldl	NOUN
easat-2730	70	11	and	and	CCONJ
easat-2730	70	12	triglycerides	triglyceride	NOUN
easat-2730	70	13	,	,	PUNCT
easat-2730	70	14	elevated	elevated	ADJ
easat-2730	70	15	oxidative	oxidative	ADJ
easat-2730	70	16	stress	stress	NOUN
easat-2730	70	17	radicals	radical	NOUN
easat-2730	70	18	,	,	PUNCT
easat-2730	70	19	inflammatory	inflammatory	ADJ
easat-2730	70	20	agents	agent	NOUN
easat-2730	70	21	,	,	PUNCT
easat-2730	70	22	and	and	CCONJ
easat-2730	70	23	unbalanced	unbalanced	ADJ
easat-2730	70	24	hemodynamic	hemodynamic	ADJ
easat-2730	70	25	activity	activity	NOUN
easat-2730	70	26	,	,	PUNCT
easat-2730	70	27	are	be	AUX
easat-2730	70	28	hypothesised	hypothesise	VERB
easat-2730	70	29	to	to	PART
easat-2730	70	30	be	be	AUX
easat-2730	70	31	responsible	responsible	ADJ
easat-2730	70	32	for	for	ADP
easat-2730	70	33	the	the	DET
easat-2730	70	34	progression	progression	NOUN
easat-2730	70	35	of	of	ADP
easat-2730	70	36	endothelial	endothelial	ADJ
easat-2730	70	37	dysfunction	dysfunction	NOUN
easat-2730	70	38	.	.	PUNCT
easat-2730	71	1	adipose	adipose	ADP
easat-2730	71	2	tissue	tissue	NOUN
easat-2730	71	3	-	-	PUNCT
easat-2730	71	4	associated	associate	VERB
easat-2730	71	5	inflammation	inflammation	NOUN
easat-2730	71	6	,	,	PUNCT
easat-2730	71	7	reduced	reduce	VERB
easat-2730	71	8	no	no	DET
easat-2730	71	9	bioavailability	bioavailability	NOUN
easat-2730	71	10	,	,	PUNCT
easat-2730	71	11	oxidized	oxidize	VERB
easat-2730	71	12	low	low	ADJ
easat-2730	71	13	-	-	PUNCT
easat-2730	71	14	density	density	NOUN
easat-2730	71	15	lipoprotein	lipoprotein	ADJ
easat-2730	71	16	(	(	PUNCT
easat-2730	71	17	oxldl	oxldl	NOUN
easat-2730	71	18	)	)	PUNCT
easat-2730	71	19	,	,	PUNCT
easat-2730	71	20	and	and	CCONJ
easat-2730	71	21	insulin	insulin	NOUN
easat-2730	71	22	resistance	resistance	NOUN
easat-2730	71	23	(	(	PUNCT
easat-2730	71	24	ir	ir	NOUN
easat-2730	71	25	)	)	PUNCT
easat-2730	71	26	are	be	AUX
easat-2730	71	27	the	the	DET
easat-2730	71	28	main	main	ADJ
easat-2730	71	29	contributing	contribute	VERB
easat-2730	71	30	factors	factor	NOUN
easat-2730	71	31	for	for	ADP
easat-2730	71	32	endothelial	endothelial	ADJ
easat-2730	71	33	dysfunction	dysfunction	NOUN
easat-2730	72	1	[	[	X
easat-2730	72	2	14	14	NUM
easat-2730	72	3	,	,	PUNCT
easat-2730	72	4	15	15	NUM
easat-2730	72	5	]	]	PUNCT
easat-2730	72	6	.	.	PUNCT
easat-2730	73	1	other	other	ADJ
easat-2730	73	2	participating	participate	VERB
easat-2730	73	3	agents	agent	NOUN
easat-2730	73	4	of	of	ADP
easat-2730	73	5	endothelial	endothelial	ADJ
easat-2730	73	6	activation	activation	NOUN
easat-2730	73	7	and	and	CCONJ
easat-2730	73	8	deregulation	deregulation	NOUN
easat-2730	73	9	included	include	VERB
easat-2730	73	10	reduced	reduce	VERB
easat-2730	73	11	tetrahydrobiopterin	tetrahydrobiopterin	NOUN
easat-2730	73	12	(	(	PUNCT
easat-2730	73	13	bh4	bh4	NOUN
easat-2730	73	14	)	)	PUNCT
easat-2730	73	15	bioavailability	bioavailability	NOUN
easat-2730	73	16	,	,	PUNCT
easat-2730	73	17	increased	increase	VERB
easat-2730	73	18	enos	eno	NOUN
easat-2730	73	19	uncoupling	uncouple	VERB
easat-2730	73	20	,	,	PUNCT
easat-2730	73	21	generation	generation	NOUN
easat-2730	73	22	of	of	ADP
easat-2730	73	23	ros	ros	PROPN
easat-2730	73	24	and	and	CCONJ
easat-2730	73	25	arginase	arginase	PROPN
easat-2730	73	26	,	,	PUNCT
easat-2730	73	27	increased	increase	VERB
easat-2730	73	28	glycation	glycation	NOUN
easat-2730	73	29	,	,	PUNCT
easat-2730	73	30	and	and	CCONJ
easat-2730	73	31	secretion	secretion	NOUN
easat-2730	73	32	of	of	ADP
easat-2730	73	33	the	the	DET
easat-2730	73	34	receptor	receptor	NOUN
easat-2730	73	35	for	for	ADP
easat-2730	73	36	advanced	advanced	ADJ
easat-2730	73	37	glycation	glycation	NOUN
easat-2730	73	38	end	end	NOUN
easat-2730	73	39	products	product	NOUN
easat-2730	73	40	(	(	PUNCT
easat-2730	73	41	rage	rage	NOUN
easat-2730	73	42	)	)	PUNCT
easat-2730	73	43	.	.	PUNCT
easat-2730	74	1	increasing	increase	VERB
easat-2730	74	2	asymmetric	asymmetric	ADJ
easat-2730	74	3	dimethylarginine	dimethylarginine	NOUN
easat-2730	74	4	,	,	PUNCT
easat-2730	74	5	activating	activate	VERB
easat-2730	74	6	nuclear	nuclear	ADJ
easat-2730	74	7	factor	factor	NOUN
easat-2730	74	8	kappa	kappa	ADJ
easat-2730	74	9	-	-	ADJ
easat-2730	74	10	light	light	ADJ
easat-2730	74	11	-	-	PUNCT
easat-2730	74	12	chain	chain	NOUN
easat-2730	74	13	enhancer	enhancer	NOUN
easat-2730	74	14	of	of	ADP
easat-2730	74	15	activated	activate	VERB
easat-2730	74	16	b	b	NOUN
easat-2730	74	17	-	-	PUNCT
easat-2730	74	18	cell	cell	NOUN
easat-2730	74	19	(	(	PUNCT
easat-2730	74	20	nf	nf	NOUN
easat-2730	74	21	-	-	PUNCT
easat-2730	74	22	kb	kb	NOUN
easat-2730	74	23	)	)	PUNCT
easat-2730	74	24	,	,	PUNCT
easat-2730	74	25	suppressing	suppress	VERB
easat-2730	74	26	kruppel	kruppel	PROPN
easat-2730	74	27	-	-	PUNCT
easat-2730	74	28	like	like	ADP
easat-2730	74	29	factor-2	factor-2	PRON
easat-2730	74	30	[	[	PUNCT
easat-2730	74	31	16	16	NUM
easat-2730	74	32	]	]	PUNCT
easat-2730	74	33	,	,	PUNCT
easat-2730	74	34	and	and	CCONJ
easat-2730	74	35	phenotypic	phenotypic	ADJ
easat-2730	74	36	changes	change	NOUN
easat-2730	74	37	in	in	ADP
easat-2730	74	38	perivascular	perivascular	ADJ
easat-2730	74	39	adipose	adipose	PRON
easat-2730	74	40	tissue	tissue	NOUN
easat-2730	74	41	leading	lead	VERB
easat-2730	74	42	to	to	ADP
easat-2730	74	43	mild	mild	ADJ
easat-2730	74	44	inflammation	inflammation	NOUN
easat-2730	74	45	and	and	CCONJ
easat-2730	74	46	higher	high	ADJ
easat-2730	74	47	leptin	leptin	NOUN
easat-2730	74	48	with	with	ADP
easat-2730	74	49	a	a	DET
easat-2730	74	50	corresponding	corresponding	ADJ
easat-2730	74	51	decrease	decrease	NOUN
easat-2730	74	52	in	in	ADP
easat-2730	74	53	adiponectin	adiponectin	NOUN
easat-2730	74	54	secretions	secretion	NOUN
easat-2730	74	55	are	be	AUX
easat-2730	74	56	other	other	ADJ
easat-2730	74	57	associated	associate	VERB
easat-2730	74	58	factors	factor	NOUN
easat-2730	74	59	[	[	X
easat-2730	74	60	6	6	NUM
easat-2730	74	61	]	]	PUNCT
easat-2730	74	62	.	.	PUNCT
easat-2730	75	1	the	the	DET
easat-2730	75	2	molecular	molecular	ADJ
easat-2730	75	3	mechanisms	mechanism	NOUN
easat-2730	75	4	for	for	ADP
easat-2730	75	5	obesity	obesity	NOUN
easat-2730	75	6	-	-	PUNCT
easat-2730	75	7	induced	induce	VERB
easat-2730	75	8	endothelial	endothelial	ADJ
easat-2730	75	9	dysfunction	dysfunction	NOUN
easat-2730	75	10	are	be	AUX
easat-2730	75	11	mostly	mostly	ADV
easat-2730	75	12	caused	cause	VERB
easat-2730	75	13	by	by	ADP
easat-2730	75	14	defective	defective	ADJ
easat-2730	75	15	no	no	DET
easat-2730	75	16	production	production	NOUN
easat-2730	75	17	and	and	CCONJ
easat-2730	75	18	enhanced	enhance	VERB
easat-2730	75	19	ros	ros	PROPN
easat-2730	75	20	secretion	secretion	NOUN
easat-2730	75	21	through	through	ADP
easat-2730	75	22	uncoupled	uncoupled	ADJ
easat-2730	75	23	enos	eno	NOUN
easat-2730	75	24	,	,	PUNCT
easat-2730	75	25	nicotinamide	nicotinamide	NOUN
easat-2730	75	26	adenine	adenine	ADJ
easat-2730	75	27	dinucleotide	dinucleotide	NOUN
easat-2730	75	28	phosphate	phosphate	NOUN
easat-2730	75	29	(	(	PUNCT
easat-2730	75	30	nadph	nadph	ADJ
easat-2730	75	31	)	)	PUNCT
easat-2730	75	32	oxidases	oxidase	NOUN
easat-2730	75	33	,	,	PUNCT
easat-2730	75	34	xanthine	xanthine	NOUN
easat-2730	75	35	oxidase	oxidase	PROPN
easat-2730	75	36	,	,	PUNCT
easat-2730	75	37	lipoxygenase	lipoxygenase	NOUN
easat-2730	75	38	,	,	PUNCT
easat-2730	75	39	cyclooxygenase	cyclooxygenase	NOUN
easat-2730	75	40	,	,	PUNCT
easat-2730	75	41	microsomal	microsomal	ADJ
easat-2730	75	42	p-450	p-450	NOUN
easat-2730	75	43	enzymes	enzyme	NOUN
easat-2730	75	44	,	,	PUNCT
easat-2730	75	45	and	and	CCONJ
easat-2730	75	46	pro	pro	ADJ
easat-2730	75	47	-	-	ADJ
easat-2730	75	48	oxidant	oxidant	ADJ
easat-2730	75	49	heme	heme	NOUN
easat-2730	75	50	molecules	molecule	NOUN
easat-2730	75	51	[	[	X
easat-2730	75	52	17	17	NUM
easat-2730	75	53	]	]	PUNCT
easat-2730	75	54	.	.	PUNCT
easat-2730	76	1	furthermore	furthermore	ADV
easat-2730	76	2	,	,	PUNCT
easat-2730	76	3	the	the	DET
easat-2730	76	4	synthesis	synthesis	NOUN
easat-2730	76	5	of	of	ADP
easat-2730	76	6	angiotensinogen	angiotensinogen	NOUN
easat-2730	76	7	of	of	ADP
easat-2730	76	8	the	the	DET
easat-2730	76	9	renin	renin	ADJ
easat-2730	76	10	-	-	PUNCT
easat-2730	76	11	angiotensin	angiotensin	NOUN
easat-2730	76	12	-	-	PUNCT
easat-2730	76	13	aldosterone	aldosterone	NOUN
easat-2730	76	14	system	system	NOUN
easat-2730	76	15	(	(	PUNCT
easat-2730	76	16	raas	raas	NOUN
easat-2730	76	17	)	)	PUNCT
easat-2730	76	18	through	through	ADP
easat-2730	76	19	defective	defective	ADJ
easat-2730	76	20	adipocytes	adipocyte	NOUN
easat-2730	76	21	may	may	AUX
easat-2730	76	22	result	result	VERB
easat-2730	76	23	in	in	ADP
easat-2730	76	24	its	its	PRON
easat-2730	76	25	increased	increase	VERB
easat-2730	76	26	secretion	secretion	NOUN
easat-2730	76	27	in	in	ADP
easat-2730	76	28	the	the	DET
easat-2730	76	29	raas	raas	NOUN
easat-2730	76	30	system	system	NOUN
easat-2730	76	31	and	and	CCONJ
easat-2730	76	32	a	a	DET
easat-2730	76	33	successive	successive	ADJ
easat-2730	76	34	increase	increase	NOUN
easat-2730	76	35	in	in	ADP
easat-2730	76	36	the	the	DET
easat-2730	76	37	secretion	secretion	NOUN
easat-2730	76	38	of	of	ADP
easat-2730	76	39	ros	ros	PROPN
easat-2730	76	40	.	.	PROPN
easat-2730	77	1	defective	defective	ADJ
easat-2730	77	2	enos	enos	PROPN
easat-2730	77	3	genes	gene	NOUN
easat-2730	77	4	facilitate	facilitate	VERB
easat-2730	77	5	endothelium	endothelium	NOUN
easat-2730	77	6	dysfunction	dysfunction	NOUN
easat-2730	77	7	by	by	ADP
easat-2730	77	8	reducing	reduce	VERB
easat-2730	77	9	no	no	DET
easat-2730	77	10	production	production	NOUN
easat-2730	77	11	[	[	X
easat-2730	77	12	17	17	NUM
easat-2730	77	13	]	]	PUNCT
easat-2730	77	14	.	.	PUNCT
easat-2730	78	1	activation	activation	NOUN
easat-2730	78	2	of	of	ADP
easat-2730	78	3	nf	nf	NOUN
easat-2730	78	4	-	-	PUNCT
easat-2730	78	5	kb	kb	NOUN
easat-2730	78	6	signalling	signal	VERB
easat-2730	78	7	molecules	molecule	NOUN
easat-2730	78	8	of	of	ADP
easat-2730	78	9	endothelial	endothelial	ADJ
easat-2730	78	10	cells	cell	NOUN
easat-2730	78	11	leads	lead	VERB
easat-2730	78	12	to	to	ADP
easat-2730	78	13	pro	pro	ADJ
easat-2730	78	14	-	-	ADJ
easat-2730	78	15	adhesive	adhesive	ADJ
easat-2730	78	16	and	and	CCONJ
easat-2730	78	17	procoagulant	procoagulant	NOUN
easat-2730	78	18	phenotypes	phenotype	NOUN
easat-2730	78	19	,	,	PUNCT
easat-2730	78	20	which	which	PRON
easat-2730	78	21	are	be	AUX
easat-2730	78	22	associated	associate	VERB
easat-2730	78	23	with	with	ADP
easat-2730	78	24	impaired	impaired	ADJ
easat-2730	78	25	vascular	vascular	ADJ
easat-2730	78	26	barrier	barrier	NOUN
easat-2730	78	27	functions	function	NOUN
easat-2730	78	28	.	.	PUNCT
easat-2730	79	1	additionally	additionally	ADV
easat-2730	79	2	,	,	PUNCT
easat-2730	79	3	nf	nf	ADJ
easat-2730	79	4	-	-	PUNCT
easat-2730	79	5	kb	kb	PROPN
easat-2730	79	6	target	target	NOUN
easat-2730	79	7	genes	gene	NOUN
easat-2730	79	8	,	,	PUNCT
easat-2730	79	9	including	include	VERB
easat-2730	79	10	adhesion	adhesion	NOUN
easat-2730	79	11	molecules	molecule	NOUN
easat-2730	79	12	,	,	PUNCT
easat-2730	79	13	such	such	ADJ
easat-2730	79	14	as	as	ADP
easat-2730	79	15	intercellular	intercellular	ADJ
easat-2730	79	16	adhesion	adhesion	NOUN
easat-2730	79	17	molecule-1	molecule-1	PROPN
easat-2730	79	18	(	(	PUNCT
easat-2730	79	19	icam-1	icam-1	NOUN
easat-2730	79	20	)	)	PUNCT
easat-2730	79	21	,	,	PUNCT
easat-2730	79	22	vascular	vascular	ADJ
easat-2730	79	23	cell	cell	NOUN
easat-2730	79	24	adhesion	adhesion	NOUN
easat-2730	79	25	molecule-1	molecule-1	PROPN
easat-2730	79	26	(	(	PUNCT
easat-2730	79	27	vcam-1	vcam-1	NOUN
easat-2730	79	28	)	)	PUNCT
easat-2730	79	29	,	,	PUNCT
easat-2730	79	30	and	and	CCONJ
easat-2730	79	31	e	e	X
easat-2730	79	32	-	-	NOUN
easat-2730	79	33	selectin	selectin	NOUN
easat-2730	79	34	,	,	PUNCT
easat-2730	79	35	which	which	PRON
easat-2730	79	36	interact	interact	VERB
easat-2730	79	37	with	with	ADP
easat-2730	79	38	inflammatory	inflammatory	ADJ
easat-2730	79	39	cytokines	cytokine	NOUN
easat-2730	79	40	of	of	ADP
easat-2730	79	41	the	the	DET
easat-2730	79	42	vascular	vascular	ADJ
easat-2730	79	43	wall	wall	NOUN
easat-2730	79	44	to	to	PART
easat-2730	79	45	facilitate	facilitate	VERB
easat-2730	79	46	extravasations	extravasation	NOUN
easat-2730	79	47	,	,	PUNCT
easat-2730	79	48	which	which	PRON
easat-2730	79	49	progres	progre	VERB
easat-2730	79	50	to	to	ADP
easat-2730	79	51	endothelial	endothelial	ADJ
easat-2730	79	52	dysfunction	dysfunction	NOUN
easat-2730	79	53	[	[	X
easat-2730	79	54	5	5	NUM
easat-2730	79	55	]	]	PUNCT
easat-2730	79	56	.	.	PUNCT
easat-2730	80	1	changes	change	NOUN
easat-2730	80	2	in	in	ADP
easat-2730	80	3	the	the	DET
easat-2730	80	4	endothelium	endothelium	NOUN
easat-2730	80	5	intercellular	intercellular	ADJ
easat-2730	80	6	matrix	matrix	NOUN
easat-2730	80	7	can	can	AUX
easat-2730	80	8	impair	impair	VERB
easat-2730	80	9	endothelial	endothelial	ADJ
easat-2730	80	10	integrity	integrity	NOUN
easat-2730	80	11	,	,	PUNCT
easat-2730	80	12	disrupt	disrupt	VERB
easat-2730	80	13	normal	normal	ADJ
easat-2730	80	14	endothelial	endothelial	ADJ
easat-2730	80	15	function	function	NOUN
easat-2730	80	16	,	,	PUNCT
easat-2730	80	17	and	and	CCONJ
easat-2730	80	18	promote	promote	VERB
easat-2730	80	19	vascular	vascular	ADJ
easat-2730	80	20	permeability	permeability	NOUN
easat-2730	80	21	.	.	PUNCT
easat-2730	81	1	these	these	PRON
easat-2730	81	2	promote	promote	VERB
easat-2730	81	3	vascular	vascular	ADJ
easat-2730	81	4	failure	failure	NOUN
easat-2730	81	5	and	and	CCONJ
easat-2730	81	6	enhance	enhance	VERB
easat-2730	81	7	the	the	DET
easat-2730	81	8	progress	progress	NOUN
easat-2730	81	9	and	and	CCONJ
easat-2730	81	10	development	development	NOUN
easat-2730	81	11	of	of	ADP
easat-2730	81	12	vascular	vascular	ADJ
easat-2730	81	13	diseases	disease	NOUN
easat-2730	81	14	,	,	PUNCT
easat-2730	81	15	including	include	VERB
easat-2730	81	16	atherosclerosis	atherosclerosis	NOUN
easat-2730	81	17	.	.	PUNCT
easat-2730	82	1	endothelial	endothelial	ADJ
easat-2730	82	2	dysfunction	dysfunction	NOUN
easat-2730	82	3	is	be	AUX
easat-2730	82	4	associated	associate	VERB
easat-2730	82	5	with	with	ADP
easat-2730	82	6	atherogenesis	atherogenesis	NOUN
easat-2730	82	7	.	.	PUNCT
easat-2730	83	1	the	the	DET
easat-2730	83	2	contributing	contribute	VERB
easat-2730	83	3	agents	agent	NOUN
easat-2730	83	4	that	that	PRON
easat-2730	83	5	enhance	enhance	VERB
easat-2730	83	6	atherogenesis	atherogenesis	NOUN
easat-2730	83	7	together	together	ADV
easat-2730	83	8	with	with	ADP
easat-2730	83	9	ox	ox	ADJ
easat-2730	83	10	-	-	NOUN
easat-2730	83	11	ldl	ldl	ADJ
easat-2730	83	12	,	,	PUNCT
easat-2730	83	13	ang	ang	PROPN
easat-2730	83	14	ii	ii	PROPN
easat-2730	83	15	,	,	PUNCT
easat-2730	83	16	and	and	CCONJ
easat-2730	83	17	hyperglycaemia	hyperglycaemia	PROPN
easat-2730	83	18	,	,	PUNCT
easat-2730	83	19	which	which	PRON
easat-2730	83	20	activate	activate	VERB
easat-2730	83	21	the	the	DET
easat-2730	83	22	functions	function	NOUN
easat-2730	83	23	of	of	ADP
easat-2730	83	24	nf	nf	NOUN
easat-2730	83	25	-	-	PUNCT
easat-2730	83	26	kb	kb	PROPN
easat-2730	83	27	and	and	CCONJ
easat-2730	83	28	mitogen	mitogen	NOUN
easat-2730	83	29	-	-	PUNCT
easat-2730	83	30	activated	activate	VERB
easat-2730	83	31	protein	protein	NOUN
easat-2730	83	32	kinase	kinase	NOUN
easat-2730	83	33	(	(	PUNCT
easat-2730	83	34	mapk	mapk	NOUN
easat-2730	83	35	)	)	PUNCT
easat-2730	83	36	of	of	ADP
easat-2730	83	37	the	the	DET
easat-2730	83	38	endothelium	endothelium	NOUN
easat-2730	83	39	.	.	PUNCT
easat-2730	84	1	these	these	PRON
easat-2730	84	2	also	also	ADV
easat-2730	84	3	activate	activate	VERB
easat-2730	84	4	proinflammatory	proinflammatory	ADJ
easat-2730	84	5	cytokines	cytokine	NOUN
easat-2730	84	6	,	,	PUNCT
easat-2730	84	7	inos	ino	NOUN
easat-2730	84	8	,	,	PUNCT
easat-2730	84	9	chemokines	chemokine	NOUN
easat-2730	84	10	,	,	PUNCT
easat-2730	84	11	causing	cause	VERB
easat-2730	84	12	an	an	DET
easat-2730	84	13	increase	increase	NOUN
easat-2730	84	14	in	in	ADP
easat-2730	84	15	the	the	DET
easat-2730	84	16	production	production	NOUN
easat-2730	84	17	of	of	ADP
easat-2730	84	18	icam-1	icam-1	NUM
easat-2730	84	19	and	and	CCONJ
easat-2730	84	20	vcam-1	vcam-1	NUM
easat-2730	84	21	,	,	PUNCT
easat-2730	84	22	enhance	enhance	VERB
easat-2730	84	23	the	the	DET
easat-2730	84	24	activities	activity	NOUN
easat-2730	84	25	of	of	ADP
easat-2730	84	26	growth	growth	NOUN
easat-2730	84	27	factors	factor	NOUN
easat-2730	84	28	,	,	PUNCT
easat-2730	84	29	and	and	CCONJ
easat-2730	84	30	other	other	ADJ
easat-2730	84	31	enzymes	enzyme	NOUN
easat-2730	84	32	[	[	X
easat-2730	84	33	10	10	NUM
easat-2730	84	34	]	]	PUNCT
easat-2730	84	35	.	.	PUNCT
easat-2730	85	1	stimulation	stimulation	NOUN
easat-2730	85	2	of	of	ADP
easat-2730	85	3	proinflammatory	proinflammatory	ADJ
easat-2730	85	4	signalling	signal	VERB
easat-2730	85	5	complexes	complex	NOUN
easat-2730	85	6	of	of	ADP
easat-2730	85	7	the	the	DET
easat-2730	85	8	inflammasomes	inflammasome	NOUN
easat-2730	85	9	and	and	CCONJ
easat-2730	85	10	oligomerization	oligomerization	NOUN
easat-2730	85	11	domain	domain	NOUN
easat-2730	85	12	-	-	PUNCT
easat-2730	85	13	like	like	ADJ
easat-2730	85	14	receptor	receptor	NOUN
easat-2730	85	15	family	family	NOUN
easat-2730	85	16	pyrin	pyrin	NOUN
easat-2730	85	17	domain	domain	NOUN
easat-2730	85	18	containing	contain	VERB
easat-2730	85	19	3	3	NUM
easat-2730	85	20	(	(	PUNCT
easat-2730	85	21	nlrp3	nlrp3	NOUN
easat-2730	85	22	)	)	PUNCT
easat-2730	85	23	promotes	promote	VERB
easat-2730	85	24	the	the	DET
easat-2730	85	25	synthesis	synthesis	NOUN
easat-2730	85	26	of	of	ADP
easat-2730	85	27	interleukins	interleukin	NOUN
easat-2730	85	28	,	,	PUNCT
easat-2730	85	29	such	such	ADJ
easat-2730	85	30	as	as	ADP
easat-2730	85	31	il-1β	il-1β	PROPN
easat-2730	85	32	and	and	CCONJ
easat-2730	85	33	il-18	il-18	ADP
easat-2730	85	34	,	,	PUNCT
easat-2730	85	35	which	which	PRON
easat-2730	85	36	activate	activate	VERB
easat-2730	85	37	the	the	DET
easat-2730	85	38	inflammatory	inflammatory	ADJ
easat-2730	85	39	processes	process	NOUN
easat-2730	85	40	[	[	X
easat-2730	85	41	18	18	NUM
easat-2730	85	42	]	]	PUNCT
easat-2730	85	43	.	.	PUNCT
easat-2730	86	1	during	during	ADP
easat-2730	86	2	atherosclerosis	atherosclerosis	NOUN
easat-2730	86	3	,	,	PUNCT
easat-2730	86	4	proinflammatory	proinflammatory	ADJ
easat-2730	86	5	signals	signal	NOUN
easat-2730	86	6	activate	activate	VERB
easat-2730	86	7	endothelial	endothelial	ADJ
easat-2730	86	8	cells	cell	NOUN
easat-2730	86	9	(	(	PUNCT
easat-2730	86	10	ecs	ecs	PROPN
easat-2730	86	11	)	)	PUNCT
easat-2730	86	12	,	,	PUNCT
easat-2730	86	13	which	which	PRON
easat-2730	86	14	facilitate	facilitate	VERB
easat-2730	86	15	the	the	DET
easat-2730	86	16	secretions	secretion	NOUN
easat-2730	86	17	of	of	ADP
easat-2730	86	18	adhesion	adhesion	NOUN
easat-2730	86	19	molecules	molecule	NOUN
easat-2730	86	20	and	and	CCONJ
easat-2730	86	21	disrupt	disrupt	VERB
easat-2730	86	22	the	the	DET
easat-2730	86	23	endothelial	endothelial	ADJ
easat-2730	86	24	barrier	barrier	NOUN
easat-2730	86	25	[	[	X
easat-2730	86	26	19	19	NUM
easat-2730	86	27	]	]	PUNCT
easat-2730	86	28	.	.	PUNCT
easat-2730	87	1	these	these	PRON
easat-2730	87	2	stimulate	stimulate	VERB
easat-2730	87	3	the	the	DET
easat-2730	87	4	movement	movement	NOUN
easat-2730	87	5	of	of	ADP
easat-2730	87	6	leukocytes	leukocyte	NOUN
easat-2730	87	7	such	such	ADJ
easat-2730	87	8	as	as	ADP
easat-2730	87	9	neutrophils	neutrophil	NOUN
easat-2730	87	10	,	,	PUNCT
easat-2730	87	11	t	t	NOUN
easat-2730	87	12	-	-	PUNCT
easat-2730	87	13	lymphocytes	lymphocyte	NOUN
easat-2730	87	14	,	,	PUNCT
easat-2730	87	15	and	and	CCONJ
easat-2730	87	16	monocytes	monocyte	NOUN
easat-2730	87	17	,	,	PUNCT
easat-2730	87	18	and	and	CCONJ
easat-2730	87	19	helps	help	VERB
easat-2730	87	20	them	they	PRON
easat-2730	87	21	to	to	PART
easat-2730	87	22	stick	stick	VERB
easat-2730	87	23	to	to	ADP
easat-2730	87	24	the	the	DET
easat-2730	87	25	endothelium	endothelium	NOUN
easat-2730	87	26	lumen	luman	NOUN
easat-2730	87	27	.	.	PUNCT
easat-2730	88	1	once	once	ADV
easat-2730	88	2	in	in	ADP
easat-2730	88	3	the	the	DET
easat-2730	88	4	endothelium	endothelium	NOUN
easat-2730	88	5	layer	layer	NOUN
easat-2730	88	6	,	,	PUNCT
easat-2730	88	7	the	the	DET
easat-2730	88	8	leukocytes	leukocyte	NOUN
easat-2730	88	9	infiltrate	infiltrate	VERB
easat-2730	88	10	the	the	DET
easat-2730	88	11	endothelial	endothelial	NOUN
easat-2730	88	12	intima	intima	NOUN
easat-2730	88	13	.	.	PUNCT
easat-2730	89	1	while	while	SCONJ
easat-2730	89	2	in	in	ADP
easat-2730	89	3	the	the	DET
easat-2730	89	4	intima	intima	NOUN
easat-2730	89	5	,	,	PUNCT
easat-2730	89	6	leukocytes	leukocyte	NOUN
easat-2730	89	7	begin	begin	VERB
easat-2730	89	8	the	the	DET
easat-2730	89	9	proatherogenic	proatherogenic	ADJ
easat-2730	89	10	inflammatory	inflammatory	ADJ
easat-2730	89	11	process	process	NOUN
easat-2730	89	12	.	.	PUNCT
easat-2730	90	1	atherosclerosis	atherosclerosis	NOUN
easat-2730	90	2	has	have	AUX
easat-2730	90	3	been	be	AUX
easat-2730	90	4	demonstrated	demonstrate	VERB
easat-2730	90	5	to	to	PART
easat-2730	90	6	originate	originate	VERB
easat-2730	90	7	from	from	ADP
easat-2730	90	8	vascular	vascular	ADJ
easat-2730	90	9	injury	injury	NOUN
easat-2730	90	10	,	,	PUNCT
easat-2730	90	11	excessive	excessive	ADJ
easat-2730	90	12	deposition	deposition	NOUN
easat-2730	90	13	of	of	ADP
easat-2730	90	14	lipids	lipid	NOUN
easat-2730	90	15	,	,	PUNCT
easat-2730	90	16	vsmcs	vsmcs	ADJ
easat-2730	90	17	migrations	migration	NOUN
easat-2730	90	18	and	and	CCONJ
easat-2730	90	19	proliferation	proliferation	NOUN
easat-2730	90	20	,	,	PUNCT
easat-2730	90	21	apoptosis	apoptosis	NOUN
easat-2730	90	22	,	,	PUNCT
easat-2730	90	23	necrosis	necrosis	NOUN
easat-2730	90	24	,	,	PUNCT
easat-2730	90	25	fibrosis	fibrosis	NOUN
easat-2730	90	26	,	,	PUNCT
easat-2730	90	27	and	and	CCONJ
easat-2730	90	28	localized	localized	ADJ
easat-2730	90	29	inflammation	inflammation	NOUN
easat-2730	90	30	[	[	X
easat-2730	90	31	20	20	NUM
easat-2730	90	32	]	]	SYM
easat-2730	90	33	.	.	PUNCT
easat-2730	91	1	immune	immune	ADJ
easat-2730	91	2	and	and	CCONJ
easat-2730	91	3	inflammatory	inflammatory	ADJ
easat-2730	91	4	responses	response	NOUN
easat-2730	91	5	have	have	AUX
easat-2730	91	6	been	be	AUX
easat-2730	91	7	implicated	implicate	VERB
easat-2730	91	8	in	in	ADP
easat-2730	91	9	various	various	ADJ
easat-2730	91	10	phases	phase	NOUN
easat-2730	91	11	of	of	ADP
easat-2730	91	12	atherosclerosis	atherosclerosis	NOUN
easat-2730	91	13	[	[	X
easat-2730	91	14	20	20	NUM
easat-2730	91	15	,	,	PUNCT
easat-2730	91	16	21	21	NUM
easat-2730	91	17	]	]	PUNCT
easat-2730	91	18	.	.	PUNCT
easat-2730	92	1	a	a	DET
easat-2730	92	2	high	high	ADJ
easat-2730	92	3	blood	blood	NOUN
easat-2730	92	4	concentration	concentration	NOUN
easat-2730	92	5	of	of	ADP
easat-2730	92	6	apolipoprotein	apolipoprotein	ADJ
easat-2730	92	7	b	b	PROPN
easat-2730	92	8	–	–	PUNCT
easat-2730	92	9	containing	contain	VERB
easat-2730	92	10	lipoproteins	lipoprotein	NOUN
easat-2730	92	11	,	,	PUNCT
easat-2730	92	12	at	at	ADP
easat-2730	92	13	which	which	PRON
easat-2730	92	14	ldl	ldl	NOUN
easat-2730	92	15	is	be	AUX
easat-2730	92	16	the	the	DET
easat-2730	92	17	predominant	predominant	ADJ
easat-2730	92	18	lipoprotein	lipoprotein	NOUN
easat-2730	92	19	,	,	PUNCT
easat-2730	92	20	has	have	AUX
easat-2730	92	21	been	be	AUX
easat-2730	92	22	recognised	recognise	VERB
easat-2730	92	23	as	as	ADP
easat-2730	92	24	the	the	DET
easat-2730	92	25	main	main	ADJ
easat-2730	92	26	cause	cause	NOUN
easat-2730	92	27	of	of	ADP
easat-2730	92	28	atherosclerosis	atherosclerosis	NOUN
easat-2730	92	29	in	in	ADP
easat-2730	92	30	obesity	obesity	NOUN
easat-2730	92	31	,	,	PUNCT
easat-2730	92	32	as	as	SCONJ
easat-2730	92	33	demonstrated	demonstrate	VERB
easat-2730	92	34	in	in	ADP
easat-2730	92	35	inherited	inherit	VERB
easat-2730	92	36	hyperlipidaemias	hyperlipidaemia	NOUN
easat-2730	92	37	(	(	PUNCT
easat-2730	92	38	monogenic	monogenic	ADJ
easat-2730	92	39	disease	disease	NOUN
easat-2730	92	40	)	)	PUNCT
easat-2730	93	1	[	[	X
easat-2730	93	2	22	22	NUM
easat-2730	93	3	,	,	PUNCT
easat-2730	93	4	23	23	NUM
easat-2730	93	5	]	]	PUNCT
easat-2730	93	6	.	.	PUNCT
easat-2730	94	1	however	however	ADV
easat-2730	94	2	,	,	PUNCT
easat-2730	94	3	the	the	DET
easat-2730	94	4	condition	condition	NOUN
easat-2730	94	5	can	can	AUX
easat-2730	94	6	occasionally	occasionally	ADV
easat-2730	94	7	develop	develop	VERB
easat-2730	94	8	even	even	ADV
easat-2730	94	9	at	at	ADP
easat-2730	94	10	lower	low	ADJ
easat-2730	94	11	concentrations	concentration	NOUN
easat-2730	94	12	when	when	SCONJ
easat-2730	94	13	coincidentally	coincidentally	ADV
easat-2730	94	14	existed	exist	VERB
easat-2730	94	15	with	with	ADP
easat-2730	94	16	other	other	ADJ
easat-2730	94	17	known	know	VERB
easat-2730	94	18	causes	cause	NOUN
easat-2730	94	19	of	of	ADP
easat-2730	94	20	atherosclerosis	atherosclerosis	NOUN
easat-2730	94	21	(	(	PUNCT
easat-2730	94	22	a	a	DET
easat-2730	94	23	multifactorial	multifactorial	ADJ
easat-2730	94	24	disease	disease	NOUN
easat-2730	94	25	)	)	PUNCT
easat-2730	94	26	,	,	PUNCT
easat-2730	94	27	including	include	VERB
easat-2730	94	28	smoking	smoking	NOUN
easat-2730	94	29	,	,	PUNCT
easat-2730	94	30	hypercholesterolemia	hypercholesterolemia	NOUN
easat-2730	94	31	,	,	PUNCT
easat-2730	94	32	hypertension	hypertension	NOUN
easat-2730	94	33	,	,	PUNCT
easat-2730	94	34	3445	3445	NUM
easat-2730	94	35	edelweiss	edelweiss	PROPN
easat-2730	94	36	applied	apply	VERB
easat-2730	94	37	science	science	NOUN
easat-2730	94	38	and	and	CCONJ
easat-2730	94	39	technology	technology	NOUN
easat-2730	94	40	issn	issn	PROPN
easat-2730	94	41	:	:	PUNCT
easat-2730	94	42	2576	2576	NUM
easat-2730	94	43	-	-	SYM
easat-2730	94	44	8484	8484	NUM
easat-2730	94	45	vol	vol	NOUN
easat-2730	94	46	.	.	PROPN
easat-2730	95	1	8	8	NUM
easat-2730	95	2	,	,	PUNCT
easat-2730	95	3	no	no	INTJ
easat-2730	95	4	.	.	NOUN
easat-2730	96	1	6	6	NUM
easat-2730	96	2	:	:	SYM
easat-2730	96	3	3441	3441	NUM
easat-2730	96	4	-	-	SYM
easat-2730	96	5	3456	3456	NUM
easat-2730	96	6	,	,	PUNCT
easat-2730	96	7	2024	2024	NUM
easat-2730	96	8	doi	doi	NOUN
easat-2730	96	9	:	:	PUNCT
easat-2730	96	10	10.55214/25768484.v8i6.2730	10.55214/25768484.v8i6.2730	NUM
easat-2730	96	11	©	©	ADP
easat-2730	96	12	2024	2024	NUM
easat-2730	96	13	by	by	ADP
easat-2730	96	14	the	the	DET
easat-2730	96	15	authors	author	NOUN
easat-2730	96	16	;	;	PUNCT
easat-2730	96	17	licensee	licensee	PROPN
easat-2730	96	18	learning	learning	PROPN
easat-2730	96	19	gate	gate	PROPN
easat-2730	96	20	hyperglycaemia	hyperglycaemia	PROPN
easat-2730	96	21	,	,	PUNCT
easat-2730	96	22	obesity	obesity	NOUN
easat-2730	96	23	,	,	PUNCT
easat-2730	96	24	chronic	chronic	ADJ
easat-2730	96	25	inflammation	inflammation	NOUN
easat-2730	96	26	,	,	PUNCT
easat-2730	96	27	diabetes	diabetes	NOUN
easat-2730	96	28	mellitus	mellitus	NOUN
easat-2730	96	29	,	,	PUNCT
easat-2730	96	30	and	and	CCONJ
easat-2730	96	31	other	other	ADJ
easat-2730	96	32	complexes	complex	NOUN
easat-2730	96	33	of	of	ADP
easat-2730	96	34	genetic	genetic	ADJ
easat-2730	96	35	factors	factor	NOUN
easat-2730	96	36	(	(	PUNCT
easat-2730	96	37	a	a	DET
easat-2730	96	38	familial	familial	ADJ
easat-2730	96	39	tendency	tendency	NOUN
easat-2730	96	40	)	)	PUNCT
easat-2730	97	1	[	[	X
easat-2730	97	2	24	24	NUM
easat-2730	97	3	]	]	PUNCT
easat-2730	97	4	.	.	PUNCT
easat-2730	98	1	during	during	ADP
easat-2730	98	2	atherosclerotic	atherosclerotic	ADJ
easat-2730	98	3	progression	progression	NOUN
easat-2730	98	4	,	,	PUNCT
easat-2730	98	5	the	the	DET
easat-2730	98	6	configuration	configuration	NOUN
easat-2730	98	7	of	of	ADP
easat-2730	98	8	the	the	DET
easat-2730	98	9	extracellular	extracellular	ADJ
easat-2730	98	10	matrix	matrix	NOUN
easat-2730	98	11	underneath	underneath	ADP
easat-2730	98	12	the	the	DET
easat-2730	98	13	endothelium	endothelium	NOUN
easat-2730	98	14	and	and	CCONJ
easat-2730	98	15	alteration	alteration	NOUN
easat-2730	98	16	of	of	ADP
easat-2730	98	17	the	the	DET
easat-2730	98	18	endothelial	endothelial	ADJ
easat-2730	98	19	permeability	permeability	NOUN
easat-2730	98	20	allow	allow	VERB
easat-2730	98	21	small	small	ADJ
easat-2730	98	22	ldl	ldl	NOUN
easat-2730	98	23	particles	particle	NOUN
easat-2730	98	24	to	to	PART
easat-2730	98	25	enter	enter	VERB
easat-2730	98	26	the	the	DET
easat-2730	98	27	endothelial	endothelial	ADJ
easat-2730	98	28	lumen	luman	NOUN
easat-2730	98	29	and	and	CCONJ
easat-2730	98	30	bind	bind	VERB
easat-2730	98	31	to	to	ADP
easat-2730	98	32	proteoglycans	proteoglycan	NOUN
easat-2730	98	33	through	through	ADP
easat-2730	98	34	apolipoprotein	apolipoprotein	ADJ
easat-2730	98	35	b-100	b-100	NOUN
easat-2730	98	36	and	and	CCONJ
easat-2730	98	37	remain	remain	VERB
easat-2730	98	38	in	in	ADP
easat-2730	98	39	the	the	DET
easat-2730	98	40	subendothelium	subendothelium	NOUN
easat-2730	98	41	[	[	X
easat-2730	98	42	25	25	NUM
easat-2730	98	43	,	,	PUNCT
easat-2730	98	44	26	26	NUM
easat-2730	98	45	]	]	PUNCT
easat-2730	98	46	.	.	PUNCT
easat-2730	99	1	the	the	DET
easat-2730	99	2	ros	ros	PROPN
easat-2730	99	3	produced	produce	VERB
easat-2730	99	4	from	from	ADP
easat-2730	99	5	reactive	reactive	ADJ
easat-2730	99	6	radicals	radical	NOUN
easat-2730	99	7	oxidizes	oxidize	VERB
easat-2730	99	8	ldl	ldl	NOUN
easat-2730	99	9	in	in	ADP
easat-2730	99	10	the	the	DET
easat-2730	99	11	endothelium	endothelium	NOUN
easat-2730	99	12	to	to	ADP
easat-2730	99	13	ox	ox	NOUN
easat-2730	99	14	-	-	NOUN
easat-2730	99	15	ldl	ldl	NOUN
easat-2730	99	16	.	.	PUNCT
easat-2730	100	1	this	this	PRON
easat-2730	100	2	activates	activate	VERB
easat-2730	100	3	many	many	ADJ
easat-2730	100	4	pro	pro	ADJ
easat-2730	100	5	-	-	ADJ
easat-2730	100	6	inflammatory	inflammatory	ADJ
easat-2730	100	7	processes	process	NOUN
easat-2730	100	8	through	through	ADP
easat-2730	100	9	lectin	lectin	NOUN
easat-2730	100	10	-	-	PUNCT
easat-2730	100	11	like	like	ADJ
easat-2730	100	12	oxidized	oxidize	VERB
easat-2730	100	13	ldl	ldl	NOUN
easat-2730	100	14	receptor-1	receptor-1	NUM
easat-2730	100	15	(	(	PUNCT
easat-2730	100	16	lox-1	lox-1	NOUN
easat-2730	100	17	)	)	PUNCT
easat-2730	100	18	.	.	PUNCT
easat-2730	101	1	ox	ox	ADJ
easat-2730	101	2	-	-	ADJ
easat-2730	101	3	ldl	ldl	ADJ
easat-2730	101	4	particles	particle	NOUN
easat-2730	101	5	facilitate	facilitate	VERB
easat-2730	101	6	endothelial	endothelial	ADJ
easat-2730	101	7	and	and	CCONJ
easat-2730	101	8	vsmc	vsmc	NOUN
easat-2730	101	9	cells	cell	NOUN
easat-2730	101	10	to	to	PART
easat-2730	101	11	produce	produce	VERB
easat-2730	101	12	a	a	DET
easat-2730	101	13	monocyte	monocyte	ADJ
easat-2730	101	14	chemotactic	chemotactic	ADJ
easat-2730	101	15	protein	protein	NOUN
easat-2730	101	16	(	(	PUNCT
easat-2730	101	17	mcp-1	mcp-1	NOUN
easat-2730	101	18	)	)	PUNCT
easat-2730	101	19	,	,	PUNCT
easat-2730	101	20	and	and	CCONJ
easat-2730	101	21	monocyte	monocyte	NOUN
easat-2730	101	22	colony	colony	NOUN
easat-2730	101	23	-	-	PUNCT
easat-2730	101	24	stimulating	stimulate	VERB
easat-2730	101	25	factor	factor	NOUN
easat-2730	101	26	(	(	PUNCT
easat-2730	101	27	m	m	NOUN
easat-2730	101	28	-	-	PUNCT
easat-2730	101	29	csf	csf	NOUN
easat-2730	101	30	)	)	PUNCT
easat-2730	101	31	that	that	PRON
easat-2730	101	32	facilitates	facilitate	VERB
easat-2730	101	33	monocyte	monocyte	NOUN
easat-2730	101	34	recruitment	recruitment	NOUN
easat-2730	102	1	[	[	X
easat-2730	102	2	21	21	NUM
easat-2730	102	3	]	]	PUNCT
easat-2730	102	4	.	.	PUNCT
easat-2730	103	1	retention	retention	NOUN
easat-2730	103	2	and	and	CCONJ
easat-2730	103	3	activation	activation	NOUN
easat-2730	103	4	of	of	ADP
easat-2730	103	5	macrophages	macrophage	NOUN
easat-2730	103	6	,	,	PUNCT
easat-2730	103	7	along	along	ADP
easat-2730	103	8	with	with	ADP
easat-2730	103	9	macrophages	macrophage	NOUN
easat-2730	103	10	,	,	PUNCT
easat-2730	103	11	encourage	encourage	VERB
easat-2730	103	12	oxldl	oxldl	ADJ
easat-2730	103	13	absorption	absorption	NOUN
easat-2730	103	14	through	through	ADP
easat-2730	103	15	the	the	DET
easat-2730	103	16	macrophages	macrophage	NOUN
easat-2730	103	17	,	,	PUNCT
easat-2730	103	18	which	which	PRON
easat-2730	103	19	results	result	VERB
easat-2730	103	20	in	in	ADP
easat-2730	103	21	the	the	DET
easat-2730	103	22	development	development	NOUN
easat-2730	103	23	of	of	ADP
easat-2730	103	24	foam	foam	NOUN
easat-2730	103	25	cells	cell	NOUN
easat-2730	103	26	(	(	PUNCT
easat-2730	103	27	fig	fig	NOUN
easat-2730	103	28	.	.	PUNCT
easat-2730	104	1	2	2	NUM
easat-2730	104	2	)	)	PUNCT
easat-2730	104	3	.	.	PUNCT
easat-2730	105	1	additionally	additionally	ADV
easat-2730	105	2	,	,	PUNCT
easat-2730	105	3	the	the	DET
easat-2730	105	4	ox	ox	NOUN
easat-2730	105	5	-	-	NOUN
easat-2730	105	6	ldl	ldl	NOUN
easat-2730	105	7	interacts	interact	VERB
easat-2730	105	8	with	with	ADP
easat-2730	105	9	healthy	healthy	ADJ
easat-2730	105	10	platelets	platelet	NOUN
easat-2730	105	11	to	to	PART
easat-2730	105	12	enhance	enhance	VERB
easat-2730	105	13	platelet	platelet	NOUN
easat-2730	105	14	activation	activation	NOUN
easat-2730	105	15	and	and	CCONJ
easat-2730	105	16	aggregation	aggregation	NOUN
easat-2730	105	17	.	.	PUNCT
easat-2730	106	1	activated	activate	VERB
easat-2730	106	2	platelets	platelet	NOUN
easat-2730	106	3	express	express	VERB
easat-2730	106	4	lox-1	lox-1	ADP
easat-2730	106	5	,	,	PUNCT
easat-2730	106	6	which	which	PRON
easat-2730	106	7	facilitates	facilitate	VERB
easat-2730	106	8	adherence	adherence	NOUN
easat-2730	106	9	of	of	ADP
easat-2730	106	10	platelets	platelet	NOUN
easat-2730	106	11	to	to	ADP
easat-2730	106	12	endothelium	endothelium	NOUN
easat-2730	106	13	and	and	CCONJ
easat-2730	106	14	triggers	trigger	VERB
easat-2730	106	15	endothelin-1	endothelin-1	DET
easat-2730	106	16	release	release	NOUN
easat-2730	106	17	.	.	PUNCT
easat-2730	107	1	these	these	DET
easat-2730	107	2	lead	lead	VERB
easat-2730	107	3	to	to	PART
easat-2730	107	4	decreased	decrease	VERB
easat-2730	107	5	endothelial	endothelial	ADJ
easat-2730	107	6	no	no	DET
easat-2730	107	7	secretion	secretion	NOUN
easat-2730	107	8	,	,	PUNCT
easat-2730	107	9	increased	increase	VERB
easat-2730	107	10	prostaglandin	prostaglandin	NOUN
easat-2730	107	11	secretion	secretion	NOUN
easat-2730	107	12	,	,	PUNCT
easat-2730	107	13	and	and	CCONJ
easat-2730	107	14	impaired	impaired	ADJ
easat-2730	107	15	endothelial	endothelial	ADJ
easat-2730	107	16	function	function	NOUN
easat-2730	107	17	.	.	PUNCT
easat-2730	108	1	rupture	rupture	NOUN
easat-2730	108	2	of	of	ADP
easat-2730	108	3	the	the	DET
easat-2730	108	4	fibrous	fibrous	ADJ
easat-2730	108	5	cap	cap	NOUN
easat-2730	108	6	of	of	ADP
easat-2730	108	7	the	the	DET
easat-2730	108	8	plaque	plaque	NOUN
easat-2730	108	9	initiates	initiate	VERB
easat-2730	108	10	an	an	DET
easat-2730	108	11	interaction	interaction	NOUN
easat-2730	108	12	between	between	ADP
easat-2730	108	13	blood	blood	NOUN
easat-2730	108	14	coagulation	coagulation	NOUN
easat-2730	108	15	factors	factor	NOUN
easat-2730	108	16	and	and	CCONJ
easat-2730	108	17	thrombogenic	thrombogenic	ADJ
easat-2730	108	18	plaque	plaque	NOUN
easat-2730	108	19	,	,	PUNCT
easat-2730	108	20	leading	lead	VERB
easat-2730	108	21	to	to	ADP
easat-2730	108	22	the	the	DET
easat-2730	108	23	production	production	NOUN
easat-2730	108	24	of	of	ADP
easat-2730	108	25	thrombi	thrombi	NOUN
easat-2730	108	26	[	[	X
easat-2730	108	27	20	20	NUM
easat-2730	108	28	,	,	PUNCT
easat-2730	108	29	25	25	NUM
easat-2730	108	30	,	,	PUNCT
easat-2730	108	31	26	26	NUM
easat-2730	108	32	]	]	PUNCT
easat-2730	108	33	.	.	PUNCT
easat-2730	109	1	endothelial	endothelial	ADJ
easat-2730	109	2	dysfunction	dysfunction	NOUN
easat-2730	109	3	is	be	AUX
easat-2730	109	4	associated	associate	VERB
easat-2730	109	5	with	with	ADP
easat-2730	109	6	impairment	impairment	NOUN
easat-2730	109	7	of	of	ADP
easat-2730	109	8	blood	blood	NOUN
easat-2730	109	9	flow	flow	NOUN
easat-2730	109	10	or	or	CCONJ
easat-2730	109	11	agonist	agonist	NOUN
easat-2730	109	12	-	-	PUNCT
easat-2730	109	13	induced	induce	VERB
easat-2730	109	14	vasodilation	vasodilation	NOUN
easat-2730	109	15	or	or	CCONJ
easat-2730	109	16	a	a	DET
easat-2730	109	17	decrease	decrease	NOUN
easat-2730	109	18	in	in	ADP
easat-2730	109	19	the	the	DET
easat-2730	109	20	essential	essential	ADJ
easat-2730	109	21	endothelium	endothelium	NOUN
easat-2730	109	22	-	-	PUNCT
easat-2730	109	23	derived	derive	VERB
easat-2730	109	24	vasodilator	vasodilator	NOUN
easat-2730	109	25	.	.	PUNCT
easat-2730	110	1	the	the	DET
easat-2730	110	2	fundamental	fundamental	ADJ
easat-2730	110	3	basic	basic	NOUN
easat-2730	110	4	of	of	ADP
easat-2730	110	5	vascular	vascular	ADJ
easat-2730	110	6	endothelial	endothelial	ADJ
easat-2730	110	7	dysfunction	dysfunction	NOUN
easat-2730	110	8	is	be	AUX
easat-2730	110	9	the	the	DET
easat-2730	110	10	impairment	impairment	NOUN
easat-2730	110	11	of	of	ADP
easat-2730	110	12	the	the	DET
easat-2730	110	13	endothelial	endothelial	ADJ
easat-2730	110	14	cells	cell	NOUN
easat-2730	110	15	,	,	PUNCT
easat-2730	110	16	which	which	PRON
easat-2730	110	17	was	be	AUX
easat-2730	110	18	investigated	investigate	VERB
easat-2730	110	19	as	as	ADP
easat-2730	110	20	the	the	DET
easat-2730	110	21	predictive	predictive	ADJ
easat-2730	110	22	future	future	NOUN
easat-2730	110	23	of	of	ADP
easat-2730	110	24	cvd	cvd	PROPN
easat-2730	110	25	events	event	NOUN
easat-2730	110	26	[	[	X
easat-2730	110	27	4	4	NUM
easat-2730	110	28	]	]	PUNCT
easat-2730	110	29	.	.	PUNCT
easat-2730	111	1	the	the	DET
easat-2730	111	2	dysfunction	dysfunction	NOUN
easat-2730	111	3	of	of	ADP
easat-2730	111	4	the	the	DET
easat-2730	111	5	endothelial	endothelial	ADJ
easat-2730	111	6	vasodilation	vasodilation	NOUN
easat-2730	111	7	has	have	AUX
easat-2730	111	8	been	be	AUX
easat-2730	111	9	demonstrated	demonstrate	VERB
easat-2730	111	10	in	in	ADP
easat-2730	111	11	several	several	ADJ
easat-2730	111	12	situations	situation	NOUN
easat-2730	111	13	,	,	PUNCT
easat-2730	111	14	such	such	ADJ
easat-2730	111	15	as	as	ADP
easat-2730	111	16	hypercholesterolaemia	hypercholesterolaemia	NOUN
easat-2730	111	17	,	,	PUNCT
easat-2730	111	18	smoking	smoking	NOUN
easat-2730	111	19	,	,	PUNCT
easat-2730	111	20	hypertension	hypertension	NOUN
easat-2730	111	21	,	,	PUNCT
easat-2730	111	22	diabetes	diabetes	NOUN
easat-2730	111	23	mellitus	mellitus	NOUN
easat-2730	111	24	,	,	PUNCT
easat-2730	111	25	heart	heart	NOUN
easat-2730	111	26	failure	failure	NOUN
easat-2730	111	27	and	and	CCONJ
easat-2730	111	28	post	post	ADJ
easat-2730	111	29	-	-	ADJ
easat-2730	111	30	ischaemic	ischaemic	ADJ
easat-2730	111	31	reperfusion	reperfusion	NOUN
easat-2730	111	32	[	[	X
easat-2730	111	33	8	8	NUM
easat-2730	111	34	]	]	PUNCT
easat-2730	111	35	.	.	PUNCT
easat-2730	112	1	due	due	ADP
easat-2730	112	2	to	to	ADP
easat-2730	112	3	complexity	complexity	NOUN
easat-2730	112	4	of	of	ADP
easat-2730	112	5	endothelium	endothelium	NOUN
easat-2730	112	6	-	-	PUNCT
easat-2730	112	7	derived	derive	VERB
easat-2730	112	8	relaxing	relaxing	ADJ
easat-2730	112	9	factors	factor	NOUN
easat-2730	112	10	,	,	PUNCT
easat-2730	112	11	many	many	ADJ
easat-2730	112	12	sites	site	NOUN
easat-2730	112	13	may	may	AUX
easat-2730	112	14	be	be	AUX
easat-2730	112	15	impacted	impact	VERB
easat-2730	112	16	.	.	PUNCT
easat-2730	113	1	these	these	PRON
easat-2730	113	2	include	include	VERB
easat-2730	113	3	endothelial	endothelial	ADJ
easat-2730	113	4	membrane	membrane	NOUN
easat-2730	113	5	receptors	receptor	NOUN
easat-2730	113	6	,	,	PUNCT
easat-2730	113	7	which	which	PRON
easat-2730	113	8	bind	bind	VERB
easat-2730	113	9	to	to	ADP
easat-2730	113	10	an	an	DET
easat-2730	113	11	agonists	agonist	NOUN
easat-2730	113	12	or	or	CCONJ
easat-2730	113	13	physiological	physiological	ADJ
easat-2730	113	14	stimuli	stimulus	NOUN
easat-2730	113	15	to	to	PART
easat-2730	113	16	secrete	secrete	VERB
easat-2730	113	17	no	no	ADV
easat-2730	113	18	,	,	PUNCT
easat-2730	113	19	decrease	decrease	VERB
easat-2730	113	20	concentrations	concentration	NOUN
easat-2730	113	21	or	or	CCONJ
easat-2730	113	22	suppress	suppress	VERB
easat-2730	113	23	the	the	DET
easat-2730	113	24	utilization	utilization	NOUN
easat-2730	113	25	of	of	ADP
easat-2730	113	26	l	l	NOUN
easat-2730	113	27	-	-	NOUN
easat-2730	113	28	arginine	arginine	NOUN
easat-2730	113	29	;	;	PUNCT
easat-2730	113	30	the	the	DET
easat-2730	113	31	substrate	substrate	NOUN
easat-2730	113	32	of	of	ADP
easat-2730	113	33	enos	eno	NOUN
easat-2730	113	34	,	,	PUNCT
easat-2730	113	35	decrease	decrease	NOUN
easat-2730	113	36	enos	eno	VERB
easat-2730	113	37	activity	activity	NOUN
easat-2730	113	38	or	or	CCONJ
easat-2730	113	39	amount	amount	NOUN
easat-2730	113	40	of	of	ADP
easat-2730	113	41	enos	eno	NOUN
easat-2730	113	42	;	;	PUNCT
easat-2730	113	43	the	the	DET
easat-2730	113	44	enzyme	enzyme	NOUN
easat-2730	113	45	involves	involve	VERB
easat-2730	113	46	with	with	ADP
easat-2730	113	47	the	the	DET
easat-2730	113	48	conversion	conversion	NOUN
easat-2730	113	49	of	of	ADP
easat-2730	113	50	l	l	NOUN
easat-2730	113	51	-	-	NOUN
easat-2730	113	52	arginine	arginine	NOUN
easat-2730	113	53	to	to	ADP
easat-2730	113	54	no	no	NOUN
easat-2730	113	55	.	.	PUNCT
easat-2730	114	1	these	these	PRON
easat-2730	114	2	altered	alter	VERB
easat-2730	114	3	the	the	DET
easat-2730	114	4	secretion	secretion	NOUN
easat-2730	114	5	of	of	ADP
easat-2730	114	6	no	no	PRON
easat-2730	114	7	from	from	ADP
easat-2730	114	8	the	the	DET
easat-2730	114	9	endothelium	endothelium	NOUN
easat-2730	114	10	,	,	PUNCT
easat-2730	114	11	and	and	CCONJ
easat-2730	114	12	promote	promote	VERB
easat-2730	114	13	the	the	DET
easat-2730	114	14	production	production	NOUN
easat-2730	114	15	of	of	ADP
easat-2730	114	16	no	no	INTJ
easat-2730	114	17	by	by	ADP
easat-2730	114	18	oxygen	oxygen	NOUN
easat-2730	114	19	free	free	ADJ
easat-2730	114	20	radicals	radical	NOUN
easat-2730	114	21	,	,	PUNCT
easat-2730	114	22	impaired	impaired	ADJ
easat-2730	114	23	diffusion	diffusion	NOUN
easat-2730	114	24	of	of	ADP
easat-2730	114	25	no	no	PRON
easat-2730	114	26	from	from	ADP
easat-2730	114	27	endothelium	endothelium	NOUN
easat-2730	114	28	to	to	ADP
easat-2730	114	29	vsmc	vsmc	NOUN
easat-2730	114	30	,	,	PUNCT
easat-2730	114	31	reduced	reduce	VERB
easat-2730	114	32	no	no	DET
easat-2730	114	33	binding	bind	VERB
easat-2730	114	34	to	to	ADP
easat-2730	114	35	guanylate	guanylate	NOUN
easat-2730	114	36	cyclase	cyclase	NOUN
easat-2730	114	37	,	,	PUNCT
easat-2730	114	38	which	which	PRON
easat-2730	114	39	limits	limit	VERB
easat-2730	114	40	the	the	DET
easat-2730	114	41	increase	increase	NOUN
easat-2730	114	42	in	in	ADP
easat-2730	114	43	intracellular	intracellular	ADJ
easat-2730	114	44	cyclic	cyclic	ADJ
easat-2730	114	45	gmp	gmp	NOUN
easat-2730	114	46	level	level	NOUN
easat-2730	114	47	,	,	PUNCT
easat-2730	114	48	altered	alter	VERB
easat-2730	114	49	no	no	DET
easat-2730	114	50	transport	transport	NOUN
easat-2730	114	51	from	from	ADP
easat-2730	114	52	endothelium	endothelium	NOUN
easat-2730	114	53	to	to	ADP
easat-2730	114	54	vsmc	vsmc	NOUN
easat-2730	114	55	,	,	PUNCT
easat-2730	114	56	and	and	CCONJ
easat-2730	114	57	generally	generally	ADV
easat-2730	114	58	reduced	reduce	VERB
easat-2730	114	59	vsmc	vsmc	NOUN
easat-2730	114	60	sensitivity	sensitivity	NOUN
easat-2730	114	61	to	to	ADP
easat-2730	114	62	vasodilators	vasodilator	NOUN
easat-2730	114	63	[	[	X
easat-2730	114	64	8	8	NUM
easat-2730	114	65	]	]	PUNCT
easat-2730	114	66	.	.	PUNCT
easat-2730	115	1	endothelial	endothelial	ADJ
easat-2730	115	2	dysfunction	dysfunction	NOUN
easat-2730	115	3	is	be	AUX
easat-2730	115	4	associated	associate	VERB
easat-2730	115	5	with	with	ADP
easat-2730	115	6	pathological	pathological	ADJ
easat-2730	115	7	condition	condition	NOUN
easat-2730	115	8	that	that	PRON
easat-2730	115	9	affects	affect	VERB
easat-2730	115	10	endothelium	endothelium	NOUN
easat-2730	115	11	on	on	ADP
easat-2730	115	12	a	a	DET
easat-2730	115	13	systemic	systemic	ADJ
easat-2730	115	14	level	level	NOUN
easat-2730	115	15	.	.	PUNCT
easat-2730	116	1	it	it	PRON
easat-2730	116	2	has	have	AUX
easat-2730	116	3	been	be	AUX
easat-2730	116	4	associated	associate	VERB
easat-2730	116	5	with	with	ADP
easat-2730	116	6	a	a	DET
easat-2730	116	7	decline	decline	NOUN
easat-2730	116	8	in	in	ADP
easat-2730	116	9	the	the	DET
easat-2730	116	10	bioavailability	bioavailability	NOUN
easat-2730	116	11	of	of	ADP
easat-2730	116	12	vasodilators	vasodilator	NOUN
easat-2730	116	13	,	,	PUNCT
easat-2730	116	14	primarily	primarily	ADV
easat-2730	116	15	the	the	DET
easat-2730	116	16	no	no	NOUN
easat-2730	116	17	,	,	PUNCT
easat-2730	116	18	which	which	PRON
easat-2730	116	19	affects	affect	VERB
easat-2730	116	20	endothelium	endothelium	NOUN
easat-2730	116	21	-	-	PUNCT
easat-2730	116	22	dependent	dependent	ADJ
easat-2730	116	23	vasodilation	vasodilation	NOUN
easat-2730	116	24	and	and	CCONJ
easat-2730	116	25	upsets	upset	VERB
easat-2730	116	26	the	the	DET
easat-2730	116	27	balance	balance	NOUN
easat-2730	116	28	between	between	ADP
easat-2730	116	29	the	the	DET
easat-2730	116	30	metabolism	metabolism	NOUN
easat-2730	116	31	and	and	CCONJ
easat-2730	116	32	function	function	NOUN
easat-2730	116	33	of	of	ADP
easat-2730	116	34	vascular	vascular	ADJ
easat-2730	116	35	walls	wall	NOUN
easat-2730	116	36	.	.	PUNCT
easat-2730	117	1	additionally	additionally	ADV
easat-2730	117	2	,	,	PUNCT
easat-2730	117	3	one	one	NUM
easat-2730	117	4	of	of	ADP
easat-2730	117	5	the	the	DET
easat-2730	117	6	primary	primary	ADJ
easat-2730	117	7	reasons	reason	NOUN
easat-2730	117	8	of	of	ADP
easat-2730	117	9	endothelial	endothelial	ADJ
easat-2730	117	10	dysfunction	dysfunction	NOUN
easat-2730	117	11	is	be	AUX
easat-2730	117	12	excess	excess	ADJ
easat-2730	117	13	ros	ro	NOUN
easat-2730	117	14	,	,	PUNCT
easat-2730	117	15	which	which	PRON
easat-2730	117	16	also	also	ADV
easat-2730	117	17	plays	play	VERB
easat-2730	117	18	a	a	DET
easat-2730	117	19	role	role	NOUN
easat-2730	117	20	to	to	ADP
easat-2730	117	21	the	the	DET
easat-2730	117	22	progress	progress	NOUN
easat-2730	117	23	of	of	ADP
easat-2730	117	24	hypertension	hypertension	NOUN
easat-2730	117	25	,	,	PUNCT
easat-2730	117	26	atherosclerosis	atherosclerosis	NOUN
easat-2730	117	27	,	,	PUNCT
easat-2730	117	28	diabetes	diabetes	NOUN
easat-2730	117	29	,	,	PUNCT
easat-2730	117	30	cardiac	cardiac	ADJ
easat-2730	117	31	hypertrophy	hypertrophy	NOUN
easat-2730	117	32	,	,	PUNCT
easat-2730	117	33	heart	heart	NOUN
easat-2730	117	34	failure	failure	NOUN
easat-2730	117	35	,	,	PUNCT
easat-2730	117	36	ischemia	ischemia	NOUN
easat-2730	117	37	-	-	PUNCT
easat-2730	117	38	reperfusion	reperfusion	NOUN
easat-2730	117	39	injury	injury	NOUN
easat-2730	117	40	,	,	PUNCT
easat-2730	117	41	and	and	CCONJ
easat-2730	117	42	stroke	stroke	NOUN
easat-2730	117	43	.	.	PUNCT
easat-2730	118	1	because	because	SCONJ
easat-2730	118	2	of	of	ADP
easat-2730	118	3	its	its	PRON
easat-2730	118	4	crucial	crucial	ADJ
easat-2730	118	5	involvement	involvement	NOUN
easat-2730	118	6	in	in	ADP
easat-2730	118	7	the	the	DET
easat-2730	118	8	emergence	emergence	NOUN
easat-2730	118	9	of	of	ADP
easat-2730	118	10	clinical	clinical	ADJ
easat-2730	118	11	coronary	coronary	ADJ
easat-2730	118	12	,	,	PUNCT
easat-2730	118	13	cerebrovascular	cerebrovascular	ADJ
easat-2730	118	14	,	,	PUNCT
easat-2730	118	15	and	and	CCONJ
easat-2730	118	16	peripheral	peripheral	ADJ
easat-2730	118	17	arterial	arterial	ADJ
easat-2730	118	18	disorders	disorder	NOUN
easat-2730	118	19	,	,	PUNCT
easat-2730	118	20	vascular	vascular	ADJ
easat-2730	118	21	endothelial	endothelial	ADJ
easat-2730	118	22	dysfunction	dysfunction	NOUN
easat-2730	118	23	is	be	AUX
easat-2730	118	24	identified	identify	VERB
easat-2730	118	25	as	as	ADP
easat-2730	118	26	the	the	DET
easat-2730	118	27	main	main	ADJ
easat-2730	118	28	therapeutic	therapeutic	ADJ
easat-2730	118	29	target	target	NOUN
easat-2730	118	30	for	for	ADP
easat-2730	118	31	inhibiting	inhibit	VERB
easat-2730	118	32	the	the	DET
easat-2730	118	33	progress	progress	NOUN
easat-2730	118	34	to	to	ADP
easat-2730	118	35	cvd	cvd	PROPN
easat-2730	118	36	morbidity	morbidity	NOUN
easat-2730	118	37	and	and	CCONJ
easat-2730	118	38	mortality	mortality	NOUN
easat-2730	119	1	[	[	X
easat-2730	119	2	5	5	NUM
easat-2730	119	3	,	,	PUNCT
easat-2730	119	4	11	11	NUM
easat-2730	119	5	]	]	PUNCT
easat-2730	119	6	.	.	PUNCT
easat-2730	120	1	therefore	therefore	ADV
easat-2730	120	2	,	,	PUNCT
easat-2730	120	3	therapeutic	therapeutic	ADJ
easat-2730	120	4	drugs	drug	NOUN
easat-2730	120	5	that	that	PRON
easat-2730	120	6	alter	alter	VERB
easat-2730	120	7	this	this	DET
easat-2730	120	8	condition	condition	NOUN
easat-2730	120	9	are	be	AUX
easat-2730	120	10	of	of	ADP
easat-2730	120	11	clinical	clinical	ADJ
easat-2730	120	12	relevance	relevance	NOUN
easat-2730	120	13	,	,	PUNCT
easat-2730	120	14	since	since	SCONJ
easat-2730	120	15	decreased	decrease	VERB
easat-2730	120	16	endothelial	endothelial	ADJ
easat-2730	120	17	function	function	NOUN
easat-2730	120	18	has	have	AUX
easat-2730	120	19	been	be	AUX
easat-2730	120	20	considered	consider	VERB
easat-2730	120	21	to	to	PART
easat-2730	120	22	play	play	VERB
easat-2730	120	23	a	a	DET
easat-2730	120	24	significant	significant	ADJ
easat-2730	120	25	causative	causative	ADJ
easat-2730	120	26	function	function	NOUN
easat-2730	120	27	to	to	ADP
easat-2730	120	28	the	the	DET
easat-2730	120	29	pathophysiology	pathophysiology	NOUN
easat-2730	120	30	of	of	ADP
easat-2730	120	31	vascular	vascular	ADJ
easat-2730	120	32	abnormalities	abnormality	NOUN
easat-2730	120	33	[	[	X
easat-2730	120	34	13	13	NUM
easat-2730	120	35	]	]	SYM
easat-2730	120	36	.	.	PUNCT
easat-2730	121	1	3446	3446	NUM
easat-2730	121	2	edelweiss	edelweiss	PROPN
easat-2730	121	3	applied	apply	VERB
easat-2730	121	4	science	science	NOUN
easat-2730	121	5	and	and	CCONJ
easat-2730	121	6	technology	technology	NOUN
easat-2730	121	7	issn	issn	PROPN
easat-2730	121	8	:	:	PUNCT
easat-2730	121	9	2576	2576	NUM
easat-2730	121	10	-	-	SYM
easat-2730	121	11	8484	8484	NUM
easat-2730	121	12	vol	vol	NOUN
easat-2730	121	13	.	.	PROPN
easat-2730	121	14	8	8	NUM
easat-2730	121	15	,	,	PUNCT
easat-2730	121	16	no	no	INTJ
easat-2730	121	17	.	.	NOUN
easat-2730	122	1	6	6	NUM
easat-2730	122	2	:	:	SYM
easat-2730	122	3	3441	3441	NUM
easat-2730	122	4	-	-	SYM
easat-2730	122	5	3456	3456	NUM
easat-2730	122	6	,	,	PUNCT
easat-2730	122	7	2024	2024	NUM
easat-2730	122	8	doi	doi	NOUN
easat-2730	122	9	:	:	PUNCT
easat-2730	122	10	10.55214/25768484.v8i6.2730	10.55214/25768484.v8i6.2730	NUM
easat-2730	122	11	©	©	ADP
easat-2730	122	12	2024	2024	NUM
easat-2730	122	13	by	by	ADP
easat-2730	122	14	the	the	DET
easat-2730	122	15	authors	author	NOUN
easat-2730	122	16	;	;	PUNCT
easat-2730	122	17	licensee	licensee	PROPN
easat-2730	122	18	learning	learn	VERB
easat-2730	122	19	gate	gate	NOUN
easat-2730	122	20	figure	figure	NOUN
easat-2730	122	21	2	2	NUM
easat-2730	122	22	.	.	PUNCT
easat-2730	122	23	mechanisms	mechanism	NOUN
easat-2730	122	24	of	of	ADP
easat-2730	122	25	obesity	obesity	NOUN
easat-2730	122	26	-	-	PUNCT
easat-2730	122	27	induced	induce	VERB
easat-2730	122	28	endothelial	endothelial	ADJ
easat-2730	122	29	dysfunction	dysfunction	NOUN
easat-2730	122	30	.	.	PUNCT
easat-2730	123	1	endothelial	endothelial	ADJ
easat-2730	123	2	dysfunction	dysfunction	NOUN
easat-2730	123	3	involved	involve	VERB
easat-2730	123	4	leukocyte	leukocyte	ADJ
easat-2730	123	5	recruitment	recruitment	NOUN
easat-2730	123	6	at	at	ADP
easat-2730	123	7	atherosclerotic	atherosclerotic	ADJ
easat-2730	123	8	lesion	lesion	NOUN
easat-2730	123	9	and	and	CCONJ
easat-2730	123	10	atherothrombotic	atherothrombotic	ADJ
easat-2730	123	11	formation	formation	NOUN
easat-2730	123	12	through	through	ADP
easat-2730	123	13	platelet	platelet	NOUN
easat-2730	123	14	activation	activation	NOUN
easat-2730	123	15	,	,	PUNCT
easat-2730	123	16	adhesion	adhesion	NOUN
easat-2730	123	17	and	and	CCONJ
easat-2730	123	18	aggregation	aggregation	NOUN
easat-2730	123	19	.	.	PUNCT
easat-2730	124	1	,	,	PUNCT
easat-2730	124	2	reduced	reduce	VERB
easat-2730	124	3	no	no	DET
easat-2730	124	4	bioavailability	bioavailability	NOUN
easat-2730	124	5	.	.	PUNCT
easat-2730	125	1	enos	eno	NOUN
easat-2730	125	2	;	;	PUNCT
easat-2730	125	3	endothelial	endothelial	ADJ
easat-2730	125	4	nitric	nitric	ADJ
easat-2730	125	5	oxide	oxide	NOUN
easat-2730	125	6	synthase	synthase	NOUN
easat-2730	125	7	,	,	PUNCT
easat-2730	125	8	ldl	ldl	NOUN
easat-2730	125	9	;	;	PUNCT
easat-2730	125	10	low	low	ADJ
easat-2730	125	11	density	density	NOUN
easat-2730	125	12	lipoprotein	lipoprotein	ADJ
easat-2730	125	13	,	,	PUNCT
easat-2730	125	14	pai-1	pai-1	NUM
easat-2730	125	15	;	;	PUNCT
easat-2730	125	16	plasminogen	plasminogen	NOUN
easat-2730	125	17	activator	activator	NOUN
easat-2730	125	18	inhibitor-1	inhibitor-1	NUM
easat-2730	125	19	,	,	PUNCT
easat-2730	125	20	tafi	tafi	PROPN
easat-2730	125	21	;	;	PUNCT
easat-2730	125	22	thrombin	thrombin	NOUN
easat-2730	125	23	activatable	activatable	ADJ
easat-2730	125	24	fibrinolysis	fibrinolysis	NOUN
easat-2730	125	25	inhibitor	inhibitor	NOUN
easat-2730	125	26	,	,	PUNCT
easat-2730	125	27	tc	tc	NUM
easat-2730	125	28	;	;	PUNCT
easat-2730	125	29	total	total	ADJ
easat-2730	125	30	cholesterol	cholesterol	NOUN
easat-2730	125	31	,	,	PUNCT
easat-2730	125	32	tg	tg	PRON
easat-2730	125	33	;	;	PUNCT
easat-2730	125	34	triglycerides	triglyceride	NOUN
easat-2730	125	35	,	,	PUNCT
easat-2730	125	36	tf	tf	NOUN
easat-2730	125	37	;	;	PUNCT
easat-2730	125	38	tissue	tissue	NOUN
easat-2730	125	39	factor	factor	NOUN
easat-2730	125	40	,	,	PUNCT
easat-2730	125	41	tfpi	tfpi	VERB
easat-2730	125	42	;	;	PUNCT
easat-2730	125	43	tissue	tissue	NOUN
easat-2730	125	44	factor	factor	NOUN
easat-2730	125	45	pathway	pathway	NOUN
easat-2730	125	46	inhibitor	inhibitor	PROPN
easat-2730	125	47	t	t	PROPN
easat-2730	125	48	-	-	PUNCT
easat-2730	125	49	pa	pa	PROPN
easat-2730	125	50	;	;	PUNCT
easat-2730	125	51	tissue	tissue	NOUN
easat-2730	125	52	plasminogen	plasminogen	NOUN
easat-2730	125	53	activator	activator	NOUN
easat-2730	125	54	[	[	X
easat-2730	125	55	modified	modify	VERB
easat-2730	125	56	26	26	NUM
easat-2730	125	57	]	]	PUNCT
easat-2730	125	58	.	.	PUNCT
easat-2730	126	1	3	3	X
easat-2730	126	2	.	.	X
easat-2730	126	3	modulation	modulation	NOUN
easat-2730	126	4	of	of	ADP
easat-2730	126	5	endothelial	endothelial	ADJ
easat-2730	126	6	dysfunction	dysfunction	NOUN
easat-2730	126	7	by	by	ADP
easat-2730	126	8	no	no	DET
easat-2730	126	9	3.1	3.1	NUM
easat-2730	126	10	.	.	PUNCT
easat-2730	126	11	mechanisms	mechanism	NOUN
easat-2730	126	12	of	of	ADP
easat-2730	126	13	no	no	DET
easat-2730	126	14	synthesis	synthesis	NOUN
easat-2730	126	15	and	and	CCONJ
easat-2730	126	16	release	release	VERB
easat-2730	126	17	no	no	PRON
easat-2730	126	18	is	be	AUX
easat-2730	126	19	among	among	ADP
easat-2730	126	20	the	the	DET
easat-2730	126	21	family	family	NOUN
easat-2730	126	22	of	of	ADP
easat-2730	126	23	endogenous	endogenous	ADJ
easat-2730	126	24	gasotransmitters	gasotransmitter	NOUN
easat-2730	126	25	associated	associate	VERB
easat-2730	126	26	with	with	ADP
easat-2730	126	27	the	the	DET
easat-2730	126	28	modulation	modulation	NOUN
easat-2730	126	29	of	of	ADP
easat-2730	126	30	different	different	ADJ
easat-2730	126	31	metabolic	metabolic	NOUN
easat-2730	126	32	processes	process	NOUN
easat-2730	126	33	,	,	PUNCT
easat-2730	126	34	including	include	VERB
easat-2730	126	35	blood	blood	NOUN
easat-2730	126	36	flow	flow	NOUN
easat-2730	126	37	and	and	CCONJ
easat-2730	126	38	platelet	platelet	NOUN
easat-2730	126	39	activation	activation	NOUN
easat-2730	126	40	,	,	PUNCT
easat-2730	126	41	adhesion	adhesion	NOUN
easat-2730	126	42	and	and	CCONJ
easat-2730	126	43	aggregation	aggregation	NOUN
easat-2730	126	44	,	,	PUNCT
easat-2730	126	45	which	which	PRON
easat-2730	126	46	are	be	AUX
easat-2730	126	47	crucial	crucial	ADJ
easat-2730	126	48	in	in	ADP
easat-2730	126	49	maintaining	maintain	VERB
easat-2730	126	50	vascular	vascular	ADJ
easat-2730	126	51	haemostasis	haemostasis	NOUN
easat-2730	126	52	.	.	PUNCT
easat-2730	127	1	it	it	PRON
easat-2730	127	2	is	be	AUX
easat-2730	127	3	constantly	constantly	ADV
easat-2730	127	4	secreted	secrete	VERB
easat-2730	127	5	from	from	ADP
easat-2730	127	6	the	the	DET
easat-2730	127	7	endothelium	endothelium	NOUN
easat-2730	127	8	by	by	ADP
easat-2730	127	9	the	the	DET
easat-2730	127	10	synthesized	synthesize	VERB
easat-2730	127	11	enos	eno	NOUN
easat-2730	127	12	.	.	PUNCT
easat-2730	128	1	previous	previous	ADJ
easat-2730	128	2	report	report	NOUN
easat-2730	128	3	has	have	AUX
easat-2730	128	4	also	also	ADV
easat-2730	128	5	investigated	investigate	VERB
easat-2730	128	6	that	that	SCONJ
easat-2730	128	7	nocan	nocan	ADV
easat-2730	128	8	be	be	AUX
easat-2730	128	9	produced	produce	VERB
easat-2730	128	10	in	in	ADP
easat-2730	128	11	the	the	DET
easat-2730	128	12	human	human	ADJ
easat-2730	128	13	placenta	placenta	NOUN
easat-2730	128	14	,	,	PUNCT
easat-2730	128	15	platelets	platelet	NOUN
easat-2730	128	16	,	,	PUNCT
easat-2730	128	17	some	some	DET
easat-2730	128	18	neurons	neuron	NOUN
easat-2730	128	19	,	,	PUNCT
easat-2730	128	20	cardiomyocytes	cardiomyocyte	NOUN
easat-2730	128	21	and	and	CCONJ
easat-2730	128	22	kidneys	kidney	NOUN
easat-2730	129	1	[	[	X
easat-2730	129	2	8	8	NUM
easat-2730	129	3	]	]	PUNCT
easat-2730	129	4	.	.	PUNCT
easat-2730	130	1	expression	expression	NOUN
easat-2730	130	2	of	of	ADP
easat-2730	130	3	enos	eno	NOUN
easat-2730	130	4	following	follow	VERB
easat-2730	130	5	ca2	ca2	PROPN
easat-2730	130	6	+	+	PROPN
easat-2730	130	7	(	(	PUNCT
easat-2730	130	8	calmodulin	calmodulin	NOUN
easat-2730	130	9	)	)	PUNCT
easat-2730	130	10	complex	complex	NOUN
easat-2730	130	11	generates	generate	VERB
easat-2730	130	12	no	no	PRON
easat-2730	130	13	through	through	ADP
easat-2730	130	14	l	l	NOUN
easat-2730	130	15	-	-	NOUN
easat-2730	130	16	arginine	arginine	NOUN
easat-2730	130	17	and	and	CCONJ
easat-2730	130	18	other	other	ADJ
easat-2730	130	19	cofactors	cofactor	NOUN
easat-2730	130	20	,	,	PUNCT
easat-2730	130	21	including	include	VERB
easat-2730	130	22	nadph	nadph	ADJ
easat-2730	130	23	,	,	PUNCT
easat-2730	130	24	tetrahydrobiopterin	tetrahydrobiopterin	NOUN
easat-2730	130	25	and	and	CCONJ
easat-2730	130	26	flavin	flavin	ADJ
easat-2730	130	27	adenine	adenine	ADJ
easat-2730	130	28	nucleotides	nucleotide	NOUN
easat-2730	130	29	as	as	ADP
easat-2730	130	30	substrates	substrate	NOUN
easat-2730	130	31	.	.	PUNCT
easat-2730	131	1	constitutive	constitutive	ADJ
easat-2730	131	2	nitric	nitric	ADJ
easat-2730	131	3	oxide	oxide	NOUN
easat-2730	131	4	synthase	synthase	NOUN
easat-2730	131	5	(	(	PUNCT
easat-2730	131	6	cnos	cno	NOUN
easat-2730	131	7	;	;	PUNCT
easat-2730	131	8	type	type	NOUN
easat-2730	131	9	iii	iii	NOUN
easat-2730	131	10	)	)	PUNCT
easat-2730	131	11	and	and	CCONJ
easat-2730	131	12	inducible	inducible	ADJ
easat-2730	131	13	nitric	nitric	ADJ
easat-2730	131	14	oxide	oxide	NOUN
easat-2730	131	15	synthase	synthase	NOUN
easat-2730	131	16	(	(	PUNCT
easat-2730	131	17	inos	inos	PROPN
easat-2730	131	18	type	type	PROPN
easat-2730	131	19	ii	ii	PROPN
easat-2730	131	20	)	)	PUNCT
easat-2730	131	21	are	be	AUX
easat-2730	131	22	the	the	DET
easat-2730	131	23	two	two	NUM
easat-2730	131	24	forms	form	NOUN
easat-2730	131	25	of	of	ADP
easat-2730	131	26	enos	eno	NOUN
easat-2730	131	27	.	.	PUNCT
easat-2730	132	1	while	while	SCONJ
easat-2730	132	2	no	no	INTJ
easat-2730	132	3	,	,	PUNCT
easat-2730	132	4	which	which	PRON
easat-2730	132	5	is	be	AUX
easat-2730	132	6	produced	produce	VERB
easat-2730	132	7	by	by	ADP
easat-2730	132	8	cnos	cno	NOUN
easat-2730	132	9	,	,	PUNCT
easat-2730	132	10	is	be	AUX
easat-2730	132	11	crucial	crucial	ADJ
easat-2730	132	12	for	for	ADP
easat-2730	132	13	controlling	control	VERB
easat-2730	132	14	blood	blood	NOUN
easat-2730	132	15	pressure	pressure	NOUN
easat-2730	132	16	[	[	X
easat-2730	132	17	8	8	NUM
easat-2730	132	18	]	]	PUNCT
easat-2730	132	19	,	,	PUNCT
easat-2730	132	20	the	the	DET
easat-2730	132	21	inos	ino	NOUN
easat-2730	132	22	is	be	AUX
easat-2730	132	23	another	another	DET
easat-2730	132	24	type	type	NOUN
easat-2730	132	25	of	of	ADP
easat-2730	132	26	nos	no	NOUN
easat-2730	132	27	that	that	PRON
easat-2730	132	28	is	be	AUX
easat-2730	132	29	ca2	ca2	PROPN
easat-2730	132	30	+	+	NOUN
easat-2730	132	31	-independent	-independent	ADJ
easat-2730	132	32	and	and	CCONJ
easat-2730	132	33	stimulated	stimulate	VERB
easat-2730	132	34	by	by	ADP
easat-2730	132	35	immune	immune	ADJ
easat-2730	132	36	factors	factor	NOUN
easat-2730	132	37	.	.	PUNCT
easat-2730	133	1	endocardial	endocardial	ADJ
easat-2730	133	2	endothelial	endothelial	NOUN
easat-2730	133	3	cells	cell	NOUN
easat-2730	133	4	produce	produce	VERB
easat-2730	133	5	the	the	DET
easat-2730	133	6	constitutive	constitutive	ADJ
easat-2730	133	7	type	type	NOUN
easat-2730	133	8	of	of	ADP
easat-2730	133	9	enos	eno	NOUN
easat-2730	133	10	,	,	PUNCT
easat-2730	133	11	which	which	PRON
easat-2730	133	12	has	have	AUX
easat-2730	133	13	been	be	AUX
easat-2730	133	14	identified	identify	VERB
easat-2730	133	15	to	to	PART
easat-2730	133	16	modify	modify	VERB
easat-2730	133	17	myocardial	myocardial	ADJ
easat-2730	133	18	contraction	contraction	NOUN
easat-2730	133	19	and	and	CCONJ
easat-2730	133	20	coronary	coronary	ADJ
easat-2730	133	21	tone	tone	NOUN
easat-2730	133	22	.	.	PUNCT
easat-2730	134	1	most	most	ADJ
easat-2730	134	2	of	of	ADP
easat-2730	134	3	the	the	DET
easat-2730	134	4	no	no	NOUN
easat-2730	134	5	in	in	ADP
easat-2730	134	6	the	the	DET
easat-2730	134	7	blood	blood	NOUN
easat-2730	134	8	arterial	arterial	NOUN
easat-2730	134	9	wall	wall	NOUN
easat-2730	134	10	is	be	AUX
easat-2730	134	11	thought	think	VERB
easat-2730	134	12	to	to	PART
easat-2730	134	13	be	be	AUX
easat-2730	134	14	produced	produce	VERB
easat-2730	134	15	by	by	ADP
easat-2730	134	16	endothelial	endothelial	ADJ
easat-2730	134	17	cnos	cno	NOUN
easat-2730	135	1	[	[	X
easat-2730	135	2	13	13	NUM
easat-2730	135	3	,	,	PUNCT
easat-2730	135	4	27	27	NUM
easat-2730	135	5	]	]	PUNCT
easat-2730	135	6	.	.	PUNCT
easat-2730	136	1	exposure	exposure	NOUN
easat-2730	136	2	of	of	ADP
easat-2730	136	3	vsmc	vsmc	NOUN
easat-2730	136	4	to	to	ADP
easat-2730	136	5	cytokines	cytokine	NOUN
easat-2730	136	6	and	and	CCONJ
easat-2730	136	7	other	other	ADJ
easat-2730	136	8	stimulators	stimulator	NOUN
easat-2730	136	9	of	of	ADP
easat-2730	136	10	enos	eno	NOUN
easat-2730	136	11	activation	activation	NOUN
easat-2730	136	12	after	after	SCONJ
easat-2730	136	13	endothelium	endothelium	NOUN
easat-2730	136	14	injury	injury	NOUN
easat-2730	136	15	may	may	AUX
easat-2730	136	16	have	have	VERB
easat-2730	136	17	significant	significant	ADJ
easat-2730	136	18	physiological	physiological	ADJ
easat-2730	136	19	effects	effect	NOUN
easat-2730	136	20	on	on	ADP
easat-2730	136	21	the	the	DET
easat-2730	136	22	blood	blood	NOUN
easat-2730	136	23	vessel	vessel	NOUN
easat-2730	136	24	.	.	PUNCT
easat-2730	137	1	after	after	ADP
easat-2730	137	2	endothelial	endothelial	NOUN
easat-2730	137	3	denudation	denudation	NOUN
easat-2730	137	4	,	,	PUNCT
easat-2730	137	5	medial	medial	ADJ
easat-2730	137	6	vsmcs	vsmcs	ADV
easat-2730	137	7	undergo	undergo	VERB
easat-2730	137	8	rapid	rapid	ADJ
easat-2730	137	9	proliferation	proliferation	NOUN
easat-2730	137	10	,	,	PUNCT
easat-2730	137	11	leading	lead	VERB
easat-2730	137	12	to	to	ADP
easat-2730	137	13	endothelial	endothelial	ADJ
easat-2730	137	14	regrowth	regrowth	NOUN
easat-2730	137	15	.	.	PUNCT
easat-2730	138	1	many	many	ADJ
easat-2730	138	2	agonists	agonist	NOUN
easat-2730	138	3	,	,	PUNCT
easat-2730	138	4	including	include	VERB
easat-2730	138	5	acetylcholine	acetylcholine	NOUN
easat-2730	138	6	,	,	PUNCT
easat-2730	138	7	histamine	histamine	NOUN
easat-2730	138	8	,	,	PUNCT
easat-2730	138	9	thrombin	thrombin	NOUN
easat-2730	138	10	,	,	PUNCT
easat-2730	138	11	serotonin	serotonin	NOUN
easat-2730	138	12	,	,	PUNCT
easat-2730	138	13	adp	adp	PROPN
easat-2730	138	14	,	,	PUNCT
easat-2730	138	15	bradykinin	bradykinin	PROPN
easat-2730	138	16	,	,	PUNCT
easat-2730	138	17	norepinephrine	norepinephrine	NOUN
easat-2730	138	18	,	,	PUNCT
easat-2730	138	19	substance	substance	NOUN
easat-2730	138	20	p	p	NOUN
easat-2730	138	21	,	,	PUNCT
easat-2730	138	22	and	and	CCONJ
easat-2730	138	23	isoproterenol	isoproterenol	NOUN
easat-2730	138	24	,	,	PUNCT
easat-2730	138	25	might	might	AUX
easat-2730	138	26	facilitate	facilitate	VERB
easat-2730	138	27	the	the	DET
easat-2730	138	28	secretion	secretion	NOUN
easat-2730	138	29	and	and	CCONJ
easat-2730	138	30	release	release	NOUN
easat-2730	138	31	of	of	ADP
easat-2730	138	32	no	no	NOUN
easat-2730	138	33	by	by	ADP
easat-2730	138	34	the	the	DET
easat-2730	138	35	endothelium	endothelium	NOUN
easat-2730	138	36	.	.	PUNCT
easat-2730	139	1	additionally	additionally	ADV
easat-2730	139	2	,	,	PUNCT
easat-2730	139	3	endothelial	endothelial	ADJ
easat-2730	139	4	bradykinin	bradykinin	NOUN
easat-2730	139	5	receptors	receptor	NOUN
easat-2730	139	6	and	and	CCONJ
easat-2730	139	7	other	other	ADJ
easat-2730	139	8	vasoactive	vasoactive	ADJ
easat-2730	139	9	substances	substance	NOUN
easat-2730	139	10	can	can	AUX
easat-2730	139	11	promote	promote	VERB
easat-2730	139	12	no	no	DET
easat-2730	139	13	release	release	NOUN
easat-2730	139	14	through	through	ADP
easat-2730	139	15	autocrine	autocrine	NOUN
easat-2730	139	16	and	and	CCONJ
easat-2730	139	17	paracrine	paracrine	NOUN
easat-2730	139	18	actions	action	NOUN
easat-2730	139	19	.	.	PUNCT
easat-2730	140	1	however	however	ADV
easat-2730	140	2	,	,	PUNCT
easat-2730	140	3	it	it	PRON
easat-2730	140	4	has	have	AUX
easat-2730	140	5	been	be	AUX
easat-2730	140	6	postulated	postulate	VERB
easat-2730	140	7	that	that	SCONJ
easat-2730	140	8	3447	3447	NUM
easat-2730	140	9	edelweiss	edelweiss	PROPN
easat-2730	140	10	applied	apply	VERB
easat-2730	140	11	science	science	NOUN
easat-2730	140	12	and	and	CCONJ
easat-2730	140	13	technology	technology	NOUN
easat-2730	140	14	issn	issn	PROPN
easat-2730	140	15	:	:	PUNCT
easat-2730	140	16	2576	2576	NUM
easat-2730	140	17	-	-	SYM
easat-2730	140	18	8484	8484	NUM
easat-2730	140	19	vol	vol	NOUN
easat-2730	140	20	.	.	PROPN
easat-2730	140	21	8	8	NUM
easat-2730	140	22	,	,	PUNCT
easat-2730	140	23	no	no	INTJ
easat-2730	140	24	.	.	NOUN
easat-2730	140	25	6	6	NUM
easat-2730	140	26	:	:	SYM
easat-2730	140	27	3441	3441	NUM
easat-2730	140	28	-	-	SYM
easat-2730	140	29	3456	3456	NUM
easat-2730	140	30	,	,	PUNCT
easat-2730	140	31	2024	2024	NUM
easat-2730	140	32	doi	doi	NOUN
easat-2730	140	33	:	:	PUNCT
easat-2730	140	34	10.55214/25768484.v8i6.2730	10.55214/25768484.v8i6.2730	NUM
easat-2730	140	35	©	©	ADP
easat-2730	140	36	2024	2024	NUM
easat-2730	140	37	by	by	ADP
easat-2730	140	38	the	the	DET
easat-2730	140	39	authors	author	NOUN
easat-2730	140	40	;	;	PUNCT
easat-2730	140	41	licensee	licensee	PROPN
easat-2730	140	42	learning	learning	NOUN
easat-2730	140	43	gate	gate	VERB
easat-2730	140	44	the	the	DET
easat-2730	140	45	fundamental	fundamental	ADJ
easat-2730	140	46	physiological	physiological	ADJ
easat-2730	140	47	stimulus	stimulus	NOUN
easat-2730	140	48	for	for	ADP
easat-2730	140	49	no	no	DET
easat-2730	140	50	production	production	NOUN
easat-2730	140	51	and	and	CCONJ
easat-2730	140	52	release	release	NOUN
easat-2730	140	53	by	by	ADP
easat-2730	140	54	the	the	DET
easat-2730	140	55	endothelium	endothelium	NOUN
easat-2730	140	56	is	be	AUX
easat-2730	140	57	shear	shear	ADJ
easat-2730	140	58	stress	stress	NOUN
easat-2730	140	59	of	of	ADP
easat-2730	140	60	the	the	DET
easat-2730	140	61	blood	blood	NOUN
easat-2730	140	62	flowing	flow	VERB
easat-2730	140	63	across	across	ADP
easat-2730	140	64	the	the	DET
easat-2730	140	65	vessel	vessel	NOUN
easat-2730	140	66	by	by	ADP
easat-2730	140	67	a	a	DET
easat-2730	140	68	non	non	ADJ
easat-2730	140	69	-	-	ADJ
easat-2730	140	70	receptor	receptor	ADJ
easat-2730	140	71	-	-	PUNCT
easat-2730	140	72	dependent	dependent	ADJ
easat-2730	140	73	process	process	NOUN
easat-2730	140	74	[	[	X
easat-2730	140	75	8	8	NUM
easat-2730	140	76	,	,	PUNCT
easat-2730	140	77	28	28	NUM
easat-2730	140	78	]	]	PUNCT
easat-2730	140	79	.	.	PUNCT
easat-2730	141	1	no	no	INTJ
easat-2730	141	2	as	as	ADP
easat-2730	141	3	a	a	DET
easat-2730	141	4	gas	gas	NOUN
easat-2730	141	5	activates	activate	VERB
easat-2730	141	6	soluble	soluble	ADJ
easat-2730	141	7	guanylyl	guanylyl	ADJ
easat-2730	141	8	cyclase	cyclase	NOUN
easat-2730	141	9	,	,	PUNCT
easat-2730	141	10	that	that	PRON
easat-2730	141	11	promote	promote	VERB
easat-2730	141	12	the	the	DET
easat-2730	141	13	production	production	NOUN
easat-2730	141	14	of	of	ADP
easat-2730	141	15	a	a	DET
easat-2730	141	16	high	high	ADJ
easat-2730	141	17	amount	amount	NOUN
easat-2730	141	18	of	of	ADP
easat-2730	141	19	cgmp	cgmp	NOUN
easat-2730	141	20	.	.	PUNCT
easat-2730	142	1	cyclic	cyclic	PROPN
easat-2730	142	2	gmp	gmp	PROPN
easat-2730	142	3	binds	bind	VERB
easat-2730	142	4	to	to	ADP
easat-2730	142	5	three	three	NUM
easat-2730	142	6	different	different	ADJ
easat-2730	142	7	intracellular	intracellular	ADJ
easat-2730	142	8	receptor	receptor	NOUN
easat-2730	142	9	proteins	protein	NOUN
easat-2730	142	10	,	,	PUNCT
easat-2730	142	11	including	include	VERB
easat-2730	142	12	cgmp	cgmp	ADJ
easat-2730	142	13	-	-	ADJ
easat-2730	142	14	dependent	dependent	ADJ
easat-2730	142	15	protein	protein	NOUN
easat-2730	142	16	kinases	kinase	NOUN
easat-2730	142	17	(	(	PUNCT
easat-2730	142	18	pkgs	pkgs	NOUN
easat-2730	142	19	)	)	PUNCT
easat-2730	142	20	,	,	PUNCT
easat-2730	142	21	cgmp	cgmp	ADJ
easat-2730	142	22	-	-	ADJ
easat-2730	142	23	regulated	regulate	VERB
easat-2730	142	24	ion	ion	NOUN
easat-2730	142	25	channels	channel	NOUN
easat-2730	142	26	,	,	PUNCT
easat-2730	142	27	and	and	CCONJ
easat-2730	142	28	cgmp	cgmp	ADV
easat-2730	142	29	-	-	PUNCT
easat-2730	142	30	regulated	regulate	VERB
easat-2730	142	31	cyclic	cyclic	ADJ
easat-2730	142	32	nucleotide	nucleotide	NOUN
easat-2730	142	33	phosphodiesterases	phosphodiesterase	NOUN
easat-2730	142	34	(	(	PUNCT
easat-2730	142	35	pdes	pde	NOUN
easat-2730	142	36	)	)	PUNCT
easat-2730	142	37	.	.	PUNCT
easat-2730	143	1	these	these	PRON
easat-2730	143	2	indicated	indicate	VERB
easat-2730	143	3	that	that	SCONJ
easat-2730	143	4	cgmp	cgmp	PROPN
easat-2730	143	5	could	could	AUX
easat-2730	143	6	modify	modify	VERB
easat-2730	143	7	cells	cell	NOUN
easat-2730	143	8	activity	activity	NOUN
easat-2730	143	9	through	through	ADP
easat-2730	143	10	protein	protein	NOUN
easat-2730	143	11	phosphorylation	phosphorylation	NOUN
easat-2730	143	12	or	or	CCONJ
easat-2730	143	13	other	other	ADJ
easat-2730	143	14	related	relate	VERB
easat-2730	143	15	proteins	protein	NOUN
easat-2730	143	16	phosphorylation	phosphorylation	NOUN
easat-2730	143	17	.	.	PUNCT
easat-2730	144	1	considering	consider	VERB
easat-2730	144	2	several	several	ADJ
easat-2730	144	3	functions	function	NOUN
easat-2730	144	4	of	of	ADP
easat-2730	144	5	cgmp	cgmp	NOUN
easat-2730	144	6	in	in	ADP
easat-2730	144	7	the	the	DET
easat-2730	144	8	physiological	physiological	ADJ
easat-2730	144	9	regulation	regulation	NOUN
easat-2730	144	10	,	,	PUNCT
easat-2730	144	11	such	such	ADJ
easat-2730	144	12	as	as	ADP
easat-2730	144	13	smooth	smooth	ADJ
easat-2730	144	14	muscle	muscle	NOUN
easat-2730	144	15	relaxation	relaxation	NOUN
easat-2730	144	16	,	,	PUNCT
easat-2730	144	17	visual	visual	ADJ
easat-2730	144	18	transmission	transmission	NOUN
easat-2730	144	19	,	,	PUNCT
easat-2730	144	20	intestinal	intestinal	ADJ
easat-2730	144	21	ion	ion	NOUN
easat-2730	144	22	transport	transport	NOUN
easat-2730	144	23	,	,	PUNCT
easat-2730	144	24	and	and	CCONJ
easat-2730	144	25	platelet	platelet	NOUN
easat-2730	144	26	activity	activity	NOUN
easat-2730	144	27	,	,	PUNCT
easat-2730	144	28	the	the	DET
easat-2730	144	29	combination	combination	NOUN
easat-2730	144	30	of	of	ADP
easat-2730	144	31	no	no	PRON
easat-2730	144	32	and	and	CCONJ
easat-2730	144	33	cgmp	cgmp	PROPN
easat-2730	144	34	might	might	AUX
easat-2730	144	35	represent	represent	VERB
easat-2730	144	36	a	a	DET
easat-2730	144	37	remarkably	remarkably	ADV
easat-2730	144	38	extensive	extensive	ADJ
easat-2730	144	39	signal	signal	NOUN
easat-2730	144	40	transduction	transduction	NOUN
easat-2730	144	41	system	system	NOUN
easat-2730	144	42	.	.	PUNCT
easat-2730	145	1	for	for	ADP
easat-2730	145	2	instance	instance	NOUN
easat-2730	145	3	,	,	PUNCT
easat-2730	145	4	increased	increase	VERB
easat-2730	145	5	cgmp	cgmp	NOUN
easat-2730	145	6	in	in	ADP
easat-2730	145	7	vsmc	vsmc	NOUN
easat-2730	145	8	beneath	beneath	ADP
easat-2730	145	9	the	the	DET
easat-2730	145	10	endothelium	endothelium	NOUN
easat-2730	145	11	facilitates	facilitate	VERB
easat-2730	145	12	gmp	gmp	PROPN
easat-2730	145	13	-	-	PUNCT
easat-2730	145	14	dependent	dependent	ADJ
easat-2730	145	15	kinase	kinase	NOUN
easat-2730	145	16	,	,	PUNCT
easat-2730	145	17	which	which	PRON
easat-2730	145	18	could	could	AUX
easat-2730	145	19	reduce	reduce	VERB
easat-2730	145	20	intracellular	intracellular	ADJ
easat-2730	145	21	calcium	calcium	NOUN
easat-2730	145	22	,	,	PUNCT
easat-2730	145	23	further	far	ADV
easat-2730	145	24	promoting	promote	VERB
easat-2730	145	25	relaxation	relaxation	NOUN
easat-2730	145	26	,	,	PUNCT
easat-2730	145	27	whereas	whereas	SCONJ
easat-2730	145	28	elevated	elevated	ADJ
easat-2730	145	29	levels	level	NOUN
easat-2730	145	30	of	of	ADP
easat-2730	145	31	cgmp	cgmp	PROPN
easat-2730	145	32	in	in	ADP
easat-2730	145	33	platelets	platelet	NOUN
easat-2730	145	34	caused	cause	VERB
easat-2730	145	35	by	by	ADP
easat-2730	145	36	no	no	DET
easat-2730	145	37	released	release	VERB
easat-2730	145	38	into	into	ADP
easat-2730	145	39	the	the	DET
easat-2730	145	40	blood	blood	NOUN
easat-2730	145	41	vessel	vessel	NOUN
easat-2730	145	42	lumen	luman	NOUN
easat-2730	145	43	,	,	PUNCT
easat-2730	145	44	reduces	reduce	VERB
easat-2730	145	45	platelet	platelet	NOUN
easat-2730	145	46	activation	activation	NOUN
easat-2730	145	47	and	and	CCONJ
easat-2730	145	48	adhesion	adhesion	NOUN
easat-2730	145	49	to	to	ADP
easat-2730	145	50	the	the	DET
easat-2730	145	51	endothelium	endothelium	NOUN
easat-2730	146	1	[	[	X
easat-2730	146	2	9	9	NUM
easat-2730	146	3	]	]	PUNCT
easat-2730	146	4	.	.	PUNCT
easat-2730	147	1	these	these	PRON
easat-2730	147	2	demonstrated	demonstrate	VERB
easat-2730	147	3	that	that	SCONJ
easat-2730	147	4	either	either	CCONJ
easat-2730	147	5	cgmp	cgmp	NOUN
easat-2730	147	6	-	-	ADJ
easat-2730	147	7	dependent	dependent	ADJ
easat-2730	147	8	or	or	CCONJ
easat-2730	147	9	cgmpindependent	cgmpindependent	NOUN
easat-2730	147	10	pathways	pathway	NOUN
easat-2730	147	11	mediate	mediate	VERB
easat-2730	147	12	the	the	DET
easat-2730	147	13	effects	effect	NOUN
easat-2730	147	14	of	of	ADP
easat-2730	147	15	no	no	NOUN
easat-2730	147	16	.	.	PUNCT
easat-2730	148	1	no	no	PRON
easat-2730	148	2	also	also	ADV
easat-2730	148	3	controls	control	VERB
easat-2730	148	4	cellular	cellular	ADJ
easat-2730	148	5	activity	activity	NOUN
easat-2730	148	6	in	in	ADP
easat-2730	148	7	the	the	DET
easat-2730	148	8	vessel	vessel	NOUN
easat-2730	148	9	wall	wall	NOUN
easat-2730	148	10	by	by	ADP
easat-2730	148	11	suppressing	suppress	VERB
easat-2730	148	12	the	the	DET
easat-2730	148	13	release	release	NOUN
easat-2730	148	14	of	of	ADP
easat-2730	148	15	growth	growth	NOUN
easat-2730	148	16	factors	factor	NOUN
easat-2730	148	17	from	from	ADP
easat-2730	148	18	both	both	DET
easat-2730	148	19	platelets	platelet	NOUN
easat-2730	148	20	and	and	CCONJ
easat-2730	148	21	cells	cell	NOUN
easat-2730	148	22	around	around	ADP
easat-2730	148	23	the	the	DET
easat-2730	148	24	vessel	vessel	NOUN
easat-2730	148	25	wall	wall	NOUN
easat-2730	149	1	[	[	X
easat-2730	149	2	8	8	NUM
easat-2730	149	3	]	]	PUNCT
easat-2730	149	4	.	.	PUNCT
easat-2730	150	1	more	more	ADV
easat-2730	150	2	specifically	specifically	ADV
easat-2730	150	3	,	,	PUNCT
easat-2730	150	4	it	it	PRON
easat-2730	150	5	is	be	AUX
easat-2730	150	6	now	now	ADV
easat-2730	150	7	believed	believe	VERB
easat-2730	150	8	that	that	SCONJ
easat-2730	150	9	the	the	DET
easat-2730	150	10	mechanism	mechanism	NOUN
easat-2730	150	11	of	of	ADP
easat-2730	150	12	cgmp	cgmp	NOUN
easat-2730	150	13	-	-	ADJ
easat-2730	150	14	induced	induced	ADJ
easat-2730	150	15	relaxation	relaxation	NOUN
easat-2730	150	16	involves	involve	VERB
easat-2730	150	17	a	a	DET
easat-2730	150	18	decrease	decrease	NOUN
easat-2730	150	19	in	in	ADP
easat-2730	150	20	intracellular	intracellular	ADJ
easat-2730	150	21	free	free	ADJ
easat-2730	150	22	ca2	ca2	PROPN
easat-2730	150	23	+	+	PROPN
easat-2730	150	24	levels	level	NOUN
easat-2730	150	25	,	,	PUNCT
easat-2730	150	26	which	which	PRON
easat-2730	150	27	serves	serve	VERB
easat-2730	150	28	as	as	ADP
easat-2730	150	29	a	a	DET
easat-2730	150	30	cue	cue	NOUN
easat-2730	150	31	to	to	PART
easat-2730	150	32	activate	activate	VERB
easat-2730	150	33	myosin	myosin	NOUN
easat-2730	150	34	light	light	NOUN
easat-2730	150	35	-	-	PUNCT
easat-2730	150	36	chain	chain	NOUN
easat-2730	150	37	kinase	kinase	NOUN
easat-2730	150	38	(	(	PUNCT
easat-2730	150	39	mlck	mlck	NOUN
easat-2730	150	40	)	)	PUNCT
easat-2730	150	41	and	and	CCONJ
easat-2730	150	42	cause	cause	VERB
easat-2730	150	43	smooth	smooth	ADJ
easat-2730	150	44	muscle	muscle	NOUN
easat-2730	150	45	to	to	PART
easat-2730	150	46	contract	contract	VERB
easat-2730	150	47	[	[	X
easat-2730	150	48	30	30	NUM
easat-2730	150	49	]	]	PUNCT
easat-2730	150	50	.	.	PUNCT
easat-2730	151	1	these	these	DET
easat-2730	151	2	reduced	reduce	VERB
easat-2730	151	3	intracellular	intracellular	ADJ
easat-2730	151	4	ca2	ca2	PROPN
easat-2730	151	5	+	+	PROPN
easat-2730	151	6	,	,	PUNCT
easat-2730	151	7	while	while	SCONJ
easat-2730	151	8	calcium	calcium	NOUN
easat-2730	151	9	channel	channel	NOUN
easat-2730	151	10	blockers	blocker	NOUN
easat-2730	151	11	naturally	naturally	ADV
easat-2730	151	12	result	result	VERB
easat-2730	151	13	in	in	ADP
easat-2730	151	14	vasodilation	vasodilation	NOUN
easat-2730	151	15	.	.	PUNCT
easat-2730	152	1	agents	agent	NOUN
easat-2730	152	2	that	that	PRON
easat-2730	152	3	promote	promote	VERB
easat-2730	152	4	camp	camp	NOUN
easat-2730	152	5	like-2	like-2	NUM
easat-2730	152	6	agonist	agonist	NOUN
easat-2730	152	7	,	,	PUNCT
easat-2730	152	8	might	might	AUX
easat-2730	152	9	lead	lead	VERB
easat-2730	152	10	to	to	ADP
easat-2730	152	11	relaxation	relaxation	NOUN
easat-2730	152	12	of	of	ADP
easat-2730	152	13	smooth	smooth	ADJ
easat-2730	152	14	muscle	muscle	NOUN
easat-2730	152	15	by	by	ADP
easat-2730	152	16	inhibiting	inhibit	VERB
easat-2730	152	17	mlck	mlck	NOUN
easat-2730	152	18	and	and	CCONJ
easat-2730	152	19	promoting	promote	VERB
easat-2730	152	20	the	the	DET
easat-2730	152	21	removal	removal	NOUN
easat-2730	152	22	of	of	ADP
easat-2730	152	23	calcium	calcium	NOUN
easat-2730	152	24	from	from	ADP
easat-2730	152	25	the	the	DET
easat-2730	152	26	cell	cell	NOUN
easat-2730	152	27	[	[	X
easat-2730	152	28	30	30	NUM
easat-2730	152	29	]	]	PUNCT
easat-2730	152	30	.	.	PUNCT
easat-2730	153	1	controlling	control	VERB
easat-2730	153	2	cgmp	cgmp	PROPN
easat-2730	153	3	levels	level	NOUN
easat-2730	153	4	,	,	PUNCT
easat-2730	153	5	and	and	CCONJ
easat-2730	153	6	hence	hence	ADV
easat-2730	153	7	the	the	DET
easat-2730	153	8	function	function	NOUN
easat-2730	153	9	of	of	ADP
easat-2730	153	10	the	the	DET
easat-2730	153	11	no	no	DET
easat-2730	153	12	-	-	PUNCT
easat-2730	153	13	cgmp	cgmp	NOUN
easat-2730	153	14	pathway	pathway	NOUN
easat-2730	153	15	needs	need	VERB
easat-2730	153	16	effective	effective	ADJ
easat-2730	153	17	controlling	control	VERB
easat-2730	153	18	phosphodiesterase	phosphodiesterase	NOUN
easat-2730	153	19	activity	activity	NOUN
easat-2730	153	20	.	.	PUNCT
easat-2730	154	1	no	no	PRON
easat-2730	154	2	exhibits	exhibit	VERB
easat-2730	154	3	anti	anti	ADJ
easat-2730	154	4	-	-	ADJ
easat-2730	154	5	inflammatory	inflammatory	ADJ
easat-2730	154	6	activities	activity	NOUN
easat-2730	154	7	,	,	PUNCT
easat-2730	154	8	which	which	PRON
easat-2730	154	9	are	be	AUX
easat-2730	154	10	accomplished	accomplish	VERB
easat-2730	154	11	by	by	ADP
easat-2730	154	12	suppressing	suppress	VERB
easat-2730	154	13	the	the	DET
easat-2730	154	14	production	production	NOUN
easat-2730	154	15	and	and	CCONJ
easat-2730	154	16	secretion	secretion	NOUN
easat-2730	154	17	of	of	ADP
easat-2730	154	18	cytokines	cytokine	NOUN
easat-2730	154	19	and	and	CCONJ
easat-2730	154	20	cell	cell	NOUN
easat-2730	154	21	adhesion	adhesion	NOUN
easat-2730	154	22	molecules	molecule	NOUN
easat-2730	154	23	,	,	PUNCT
easat-2730	154	24	which	which	PRON
easat-2730	154	25	mobilized	mobilize	VERB
easat-2730	154	26	inflammatory	inflammatory	ADJ
easat-2730	154	27	cells	cell	NOUN
easat-2730	154	28	to	to	ADP
easat-2730	154	29	the	the	DET
easat-2730	154	30	endothelium	endothelium	NOUN
easat-2730	154	31	and	and	CCONJ
easat-2730	154	32	promote	promote	VERB
easat-2730	154	33	their	their	PRON
easat-2730	154	34	recruitment	recruitment	NOUN
easat-2730	154	35	to	to	ADP
easat-2730	154	36	the	the	DET
easat-2730	154	37	endothelial	endothelial	ADJ
easat-2730	154	38	lumen	luman	NOUN
easat-2730	154	39	.	.	PUNCT
easat-2730	155	1	the	the	DET
easat-2730	155	2	suppression	suppression	NOUN
easat-2730	155	3	of	of	ADP
easat-2730	155	4	nf	nf	ADJ
easat-2730	155	5	-	-	PUNCT
easat-2730	155	6	kb	kb	NOUN
easat-2730	155	7	activity	activity	NOUN
easat-2730	155	8	,	,	PUNCT
easat-2730	155	9	can	can	AUX
easat-2730	155	10	bind	bind	VERB
easat-2730	155	11	to	to	ADP
easat-2730	155	12	the	the	DET
easat-2730	155	13	promoter	promoter	NOUN
easat-2730	155	14	regions	region	NOUN
easat-2730	155	15	of	of	ADP
easat-2730	155	16	genes	gene	NOUN
easat-2730	155	17	encoding	encode	VERB
easat-2730	155	18	pro	pro	ADJ
easat-2730	155	19	-	-	ADJ
easat-2730	155	20	inflammatory	inflammatory	ADJ
easat-2730	155	21	proteins	protein	NOUN
easat-2730	155	22	[	[	X
easat-2730	155	23	8	8	NUM
easat-2730	155	24	]	]	PUNCT
easat-2730	155	25	.	.	PUNCT
easat-2730	156	1	no	no	PRON
easat-2730	156	2	also	also	ADV
easat-2730	156	3	controls	control	VERB
easat-2730	156	4	the	the	DET
easat-2730	156	5	baseline	baseline	NOUN
easat-2730	156	6	tone	tone	NOUN
easat-2730	156	7	of	of	ADP
easat-2730	156	8	the	the	DET
easat-2730	156	9	systemic	systemic	ADJ
easat-2730	156	10	,	,	PUNCT
easat-2730	156	11	coronary	coronary	ADJ
easat-2730	156	12	,	,	PUNCT
easat-2730	156	13	and	and	CCONJ
easat-2730	156	14	pulmonary	pulmonary	ADJ
easat-2730	156	15	arteries	artery	NOUN
easat-2730	156	16	by	by	ADP
easat-2730	156	17	an	an	DET
easat-2730	156	18	increase	increase	NOUN
easat-2730	156	19	in	in	ADP
easat-2730	156	20	cgmp	cgmp	NOUN
easat-2730	156	21	in	in	ADP
easat-2730	156	22	smooth	smooth	ADJ
easat-2730	156	23	muscle	muscle	NOUN
easat-2730	156	24	,	,	PUNCT
easat-2730	156	25	suppression	suppression	NOUN
easat-2730	156	26	of	of	ADP
easat-2730	156	27	the	the	DET
easat-2730	156	28	potent	potent	ADJ
easat-2730	156	29	constrictor	constrictor	NOUN
easat-2730	156	30	peptide	peptide	NOUN
easat-2730	156	31	endothelin-1	endothelin-1	PROPN
easat-2730	156	32	,	,	PUNCT
easat-2730	156	33	and	and	CCONJ
easat-2730	156	34	attenuation	attenuation	NOUN
easat-2730	156	35	for	for	ADP
easat-2730	156	36	the	the	DET
easat-2730	156	37	release	release	NOUN
easat-2730	156	38	of	of	ADP
easat-2730	156	39	norepinephrine	norepinephrine	NOUN
easat-2730	156	40	from	from	ADP
easat-2730	156	41	sympathetic	sympathetic	ADJ
easat-2730	156	42	nerve	nerve	NOUN
easat-2730	156	43	terminals	terminal	NOUN
easat-2730	156	44	[	[	X
easat-2730	156	45	13	13	NUM
easat-2730	156	46	]	]	PUNCT
easat-2730	156	47	.	.	PUNCT
easat-2730	157	1	additional	additional	ADJ
easat-2730	157	2	mechanism	mechanism	NOUN
easat-2730	157	3	that	that	PRON
easat-2730	157	4	is	be	AUX
easat-2730	157	5	involved	involve	VERB
easat-2730	157	6	in	in	ADP
easat-2730	157	7	the	the	DET
easat-2730	157	8	generation	generation	NOUN
easat-2730	157	9	of	of	ADP
easat-2730	157	10	enos	eno	NOUN
easat-2730	157	11	-	-	PUNCT
easat-2730	157	12	derived	derive	VERB
easat-2730	157	13	no	no	NOUN
easat-2730	157	14	is	be	AUX
easat-2730	157	15	the	the	DET
easat-2730	157	16	activation	activation	NOUN
easat-2730	157	17	of	of	ADP
easat-2730	157	18	βadrenoreceptors	βadrenoreceptor	NOUN
easat-2730	157	19	in	in	ADP
easat-2730	157	20	response	response	NOUN
easat-2730	157	21	to	to	ADP
easat-2730	157	22	high	high	ADJ
easat-2730	157	23	concentration	concentration	NOUN
easat-2730	157	24	of	of	ADP
easat-2730	157	25	catecholamine	catecholamine	NOUN
easat-2730	157	26	that	that	PRON
easat-2730	157	27	are	be	AUX
easat-2730	157	28	enhanced	enhance	VERB
easat-2730	157	29	at	at	ADP
easat-2730	157	30	higher	high	ADJ
easat-2730	157	31	amount	amount	NOUN
easat-2730	157	32	in	in	ADP
easat-2730	157	33	oxidative	oxidative	ADJ
easat-2730	157	34	stress	stress	NOUN
easat-2730	157	35	linked	link	VERB
easat-2730	157	36	to	to	ADP
easat-2730	157	37	endothelial	endothelial	ADJ
easat-2730	157	38	dysfunction	dysfunction	NOUN
easat-2730	157	39	[	[	X
easat-2730	157	40	8	8	NUM
easat-2730	157	41	]	]	PUNCT
easat-2730	157	42	.	.	PUNCT
easat-2730	158	1	additionally	additionally	ADV
easat-2730	158	2	,	,	PUNCT
easat-2730	158	3	the	the	DET
easat-2730	158	4	vsmc	vsmc	NOUN
easat-2730	158	5	could	could	AUX
easat-2730	158	6	absorb	absorb	VERB
easat-2730	158	7	no	no	PRON
easat-2730	158	8	,	,	PUNCT
easat-2730	158	9	which	which	PRON
easat-2730	158	10	interacts	interact	VERB
easat-2730	158	11	with	with	ADP
easat-2730	158	12	a	a	DET
easat-2730	158	13	heme	heme	NOUN
easat-2730	158	14	-	-	PUNCT
easat-2730	158	15	iron	iron	NOUN
easat-2730	158	16	group	group	NOUN
easat-2730	158	17	of	of	ADP
easat-2730	158	18	guanylate	guanylate	NOUN
easat-2730	158	19	cyclase	cyclase	NOUN
easat-2730	158	20	to	to	PART
easat-2730	158	21	generate	generate	VERB
easat-2730	158	22	cgmp	cgmp	NOUN
easat-2730	158	23	.	.	PUNCT
easat-2730	159	1	this	this	PRON
easat-2730	159	2	promotes	promote	VERB
easat-2730	159	3	a	a	DET
easat-2730	159	4	cgmp	cgmp	ADJ
easat-2730	159	5	-	-	ADJ
easat-2730	159	6	dependent	dependent	ADJ
easat-2730	159	7	protein	protein	NOUN
easat-2730	159	8	kinase	kinase	NOUN
easat-2730	159	9	,	,	PUNCT
easat-2730	159	10	raises	raise	VERB
easat-2730	159	11	the	the	DET
easat-2730	159	12	ca2	ca2	PROPN
easat-2730	159	13	+	+	PROPN
easat-2730	159	14	level	level	NOUN
easat-2730	159	15	in	in	ADP
easat-2730	159	16	the	the	DET
easat-2730	159	17	vsmc	vsmc	NOUN
easat-2730	159	18	's	's	PART
easat-2730	159	19	cytosol	cytosol	NOUN
easat-2730	159	20	,	,	PUNCT
easat-2730	159	21	and	and	CCONJ
easat-2730	159	22	subsequently	subsequently	ADV
easat-2730	159	23	inhibit	inhibit	VERB
easat-2730	159	24	vasoconstriction	vasoconstriction	NOUN
easat-2730	159	25	,	,	PUNCT
easat-2730	159	26	while	while	SCONJ
easat-2730	159	27	facilitating	facilitate	VERB
easat-2730	159	28	vasodilation	vasodilation	NOUN
easat-2730	159	29	[	[	X
easat-2730	159	30	13	13	NUM
easat-2730	159	31	]	]	PUNCT
easat-2730	159	32	.	.	PUNCT
easat-2730	160	1	also	also	ADV
easat-2730	160	2	,	,	PUNCT
easat-2730	160	3	no	no	PRON
easat-2730	160	4	interacts	interact	VERB
easat-2730	160	5	with	with	ADP
easat-2730	160	6	kruppel	kruppel	PROPN
easat-2730	160	7	-	-	PUNCT
easat-2730	160	8	like	like	ADJ
easat-2730	160	9	factor-2	factor-2	NUM
easat-2730	160	10	and	and	CCONJ
easat-2730	160	11	endothelium	endothelium	NOUN
easat-2730	160	12	-	-	PUNCT
easat-2730	160	13	derived	derive	VERB
easat-2730	160	14	hyperpolarizing	hyperpolarizing	NOUN
easat-2730	160	15	factor	factor	NOUN
easat-2730	160	16	(	(	PUNCT
easat-2730	160	17	edhf	edhf	NOUN
easat-2730	160	18	)	)	PUNCT
easat-2730	160	19	to	to	PART
easat-2730	160	20	promote	promote	VERB
easat-2730	160	21	arterial	arterial	ADJ
easat-2730	160	22	vasodilation	vasodilation	NOUN
easat-2730	160	23	[	[	X
easat-2730	160	24	31	31	NUM
easat-2730	160	25	]	]	PUNCT
easat-2730	160	26	.	.	PUNCT
easat-2730	161	1	it	it	PRON
easat-2730	161	2	suppresses	suppress	VERB
easat-2730	161	3	the	the	DET
easat-2730	161	4	synthesis	synthesis	NOUN
easat-2730	161	5	of	of	ADP
easat-2730	161	6	nf	nf	NOUN
easat-2730	161	7	-	-	PUNCT
easat-2730	161	8	kb	kb	NOUN
easat-2730	161	9	by	by	ADP
easat-2730	161	10	inhibiting	inhibit	VERB
easat-2730	161	11	the	the	DET
easat-2730	161	12	secretion	secretion	NOUN
easat-2730	161	13	of	of	ADP
easat-2730	161	14	vcam-1	vcam-1	NOUN
easat-2730	161	15	and	and	CCONJ
easat-2730	161	16	mcp-1	mcp-1	NOUN
easat-2730	161	17	activities	activity	NOUN
easat-2730	161	18	[	[	X
easat-2730	161	19	3	3	NUM
easat-2730	161	20	]	]	PUNCT
easat-2730	161	21	.	.	PUNCT
easat-2730	162	1	it	it	PRON
easat-2730	162	2	is	be	AUX
easat-2730	162	3	also	also	ADV
easat-2730	162	4	an	an	DET
easat-2730	162	5	effective	effective	ADJ
easat-2730	162	6	endothelium	endothelium	NOUN
easat-2730	162	7	-	-	PUNCT
easat-2730	162	8	derived	derive	VERB
easat-2730	162	9	vasodilator	vasodilator	NOUN
easat-2730	162	10	that	that	PRON
easat-2730	162	11	exhibits	exhibit	VERB
easat-2730	162	12	antiplatelet	antiplatelet	NOUN
easat-2730	162	13	,	,	PUNCT
easat-2730	162	14	antiproliferative	antiproliferative	NOUN
easat-2730	162	15	and	and	CCONJ
easat-2730	162	16	antiinflammatory	antiinflammatory	NOUN
easat-2730	162	17	properties	property	NOUN
easat-2730	162	18	,	,	PUNCT
easat-2730	162	19	and	and	CCONJ
easat-2730	162	20	decrease	decrease	VERB
easat-2730	162	21	endothelial	endothelial	ADJ
easat-2730	162	22	permeability[8	permeability[8	NOUN
easat-2730	162	23	]	]	PUNCT
easat-2730	162	24	.	.	PUNCT
easat-2730	163	1	moreover	moreover	ADV
easat-2730	163	2	,	,	PUNCT
easat-2730	163	3	the	the	DET
easat-2730	163	4	oxygenase	oxygenase	NOUN
easat-2730	163	5	domain	domain	NOUN
easat-2730	163	6	of	of	ADP
easat-2730	163	7	no	no	DET
easat-2730	163	8	proteins	protein	NOUN
easat-2730	163	9	is	be	AUX
easat-2730	163	10	a	a	DET
easat-2730	163	11	homodimer	homodimer	NOUN
easat-2730	163	12	that	that	SCONJ
easat-2730	163	13	transfers	transfer	VERB
easat-2730	163	14	electrons	electron	NOUN
easat-2730	163	15	from	from	ADP
easat-2730	163	16	nadph	nadph	ADJ
easat-2730	163	17	to	to	ADP
easat-2730	163	18	the	the	DET
easat-2730	163	19	haem	haem	NOUN
easat-2730	163	20	,	,	PUNCT
easat-2730	163	21	where	where	SCONJ
easat-2730	163	22	they	they	PRON
easat-2730	163	23	are	be	AUX
easat-2730	163	24	utilized	utilize	VERB
easat-2730	163	25	to	to	PART
easat-2730	163	26	decrease	decrease	VERB
easat-2730	163	27	o2	o2	PROPN
easat-2730	163	28	and	and	CCONJ
easat-2730	163	29	oxidize	oxidize	VERB
easat-2730	163	30	l	l	NOUN
easat-2730	163	31	-	-	NOUN
easat-2730	163	32	arginine	arginine	NOUN
easat-2730	163	33	to	to	ADP
easat-2730	163	34	l	l	NOUN
easat-2730	163	35	-	-	NOUN
easat-2730	163	36	citrulline	citrulline	NOUN
easat-2730	163	37	and	and	CCONJ
easat-2730	163	38	no	no	NOUN
easat-2730	163	39	.	.	PUNCT
easat-2730	164	1	other	other	ADJ
easat-2730	164	2	binding	bind	VERB
easat-2730	164	3	sites	site	NOUN
easat-2730	164	4	in	in	ADP
easat-2730	164	5	this	this	DET
easat-2730	164	6	domain	domain	NOUN
easat-2730	164	7	include	include	VERB
easat-2730	164	8	those	those	PRON
easat-2730	164	9	for	for	ADP
easat-2730	164	10	bh4	bh4	NOUN
easat-2730	164	11	,	,	PUNCT
easat-2730	164	12	oxygen	oxygen	NOUN
easat-2730	164	13	,	,	PUNCT
easat-2730	164	14	and	and	CCONJ
easat-2730	164	15	l	l	NOUN
easat-2730	164	16	-	-	NOUN
easat-2730	164	17	arginine	arginine	NOUN
easat-2730	164	18	.	.	PUNCT
easat-2730	165	1	importantly	importantly	ADV
easat-2730	165	2	,	,	PUNCT
easat-2730	165	3	when	when	SCONJ
easat-2730	165	4	there	there	PRON
easat-2730	165	5	is	be	VERB
easat-2730	165	6	increased	increase	VERB
easat-2730	165	7	oxidative	oxidative	ADJ
easat-2730	165	8	stress	stress	NOUN
easat-2730	165	9	,	,	PUNCT
easat-2730	165	10	enos	enos	PROPN
easat-2730	165	11	could	could	AUX
easat-2730	165	12	lose	lose	VERB
easat-2730	165	13	its	its	PRON
easat-2730	165	14	physiological	physiological	ADJ
easat-2730	165	15	functions	function	NOUN
easat-2730	165	16	in	in	ADP
easat-2730	165	17	a	a	DET
easat-2730	165	18	situation	situation	NOUN
easat-2730	165	19	known	know	VERB
easat-2730	165	20	as	as	ADP
easat-2730	165	21	"	"	PUNCT
easat-2730	165	22	enos	eno	NOUN
easat-2730	165	23	uncoupling	uncouple	VERB
easat-2730	165	24	"	"	PUNCT
easat-2730	165	25	[	[	X
easat-2730	165	26	32	32	NUM
easat-2730	165	27	]	]	PUNCT
easat-2730	165	28	.	.	PUNCT
easat-2730	166	1	in	in	ADP
easat-2730	166	2	such	such	DET
easat-2730	166	3	a	a	DET
easat-2730	166	4	situation	situation	NOUN
easat-2730	166	5	,	,	PUNCT
easat-2730	166	6	no	no	PRON
easat-2730	166	7	binds	bind	VERB
easat-2730	166	8	to	to	PART
easat-2730	166	9	superoxide	superoxide	VERB
easat-2730	166	10	o2	o2	PROPN
easat-2730	166	11	to	to	PART
easat-2730	166	12	form	form	VERB
easat-2730	166	13	peroxynitrite	peroxynitrite	ADJ
easat-2730	166	14	(	(	PUNCT
easat-2730	166	15	onoo	onoo	ADJ
easat-2730	166	16	)	)	PUNCT
easat-2730	166	17	,	,	PUNCT
easat-2730	166	18	a	a	DET
easat-2730	166	19	potent	potent	ADJ
easat-2730	166	20	inducer	inducer	NOUN
easat-2730	166	21	of	of	ADP
easat-2730	166	22	apoptosis	apoptosis	NOUN
easat-2730	166	23	,	,	PUNCT
easat-2730	166	24	while	while	SCONJ
easat-2730	166	25	enos	eno	NOUN
easat-2730	166	26	instead	instead	ADV
easat-2730	166	27	may	may	AUX
easat-2730	166	28	produce	produce	VERB
easat-2730	166	29	ros	ros	PROPN
easat-2730	166	30	,	,	PUNCT
easat-2730	166	31	primarily	primarily	ADV
easat-2730	166	32	o2	o2	PROPN
easat-2730	166	33	(	(	PUNCT
easat-2730	166	34	fig	fig	NOUN
easat-2730	166	35	3	3	NUM
easat-2730	166	36	)	)	PUNCT
easat-2730	166	37	.	.	PUNCT
easat-2730	167	1	hence	hence	ADV
easat-2730	167	2	,	,	PUNCT
easat-2730	167	3	enos	enos	PROPN
easat-2730	167	4	uncoupling	uncouple	VERB
easat-2730	167	5	not	not	PART
easat-2730	167	6	only	only	ADV
easat-2730	167	7	causes	cause	VERB
easat-2730	167	8	a	a	DET
easat-2730	167	9	reduction	reduction	NOUN
easat-2730	167	10	in	in	ADP
easat-2730	167	11	no	no	DET
easat-2730	167	12	bioavailability	bioavailability	NOUN
easat-2730	167	13	but	but	CCONJ
easat-2730	167	14	also	also	ADV
easat-2730	167	15	promotes	promote	VERB
easat-2730	167	16	preexisting	preexist	VERB
easat-2730	167	17	oxidative	oxidative	ADJ
easat-2730	167	18	stress	stress	NOUN
easat-2730	167	19	.	.	PUNCT
easat-2730	168	1	the	the	DET
easat-2730	168	2	oxidation	oxidation	NOUN
easat-2730	168	3	of	of	ADP
easat-2730	168	4	bh4	bh4	NOUN
easat-2730	168	5	to	to	ADP
easat-2730	168	6	the	the	DET
easat-2730	168	7	deactivated	deactivate	VERB
easat-2730	168	8	form	form	NOUN
easat-2730	168	9	bh3	bh3	VERB
easat-2730	168	10	by	by	ADP
easat-2730	168	11	o2	o2	PROPN
easat-2730	168	12	and	and	CCONJ
easat-2730	168	13	onoo	onoo	ADJ
easat-2730	168	14	,	,	PUNCT
easat-2730	168	15	as	as	ADV
easat-2730	168	16	well	well	ADV
easat-2730	168	17	as	as	ADP
easat-2730	168	18	the	the	DET
easat-2730	168	19	depletion	depletion	NOUN
easat-2730	168	20	of	of	ADP
easat-2730	168	21	l	l	NOUN
easat-2730	168	22	-	-	NOUN
easat-2730	168	23	arginine	arginine	NOUN
easat-2730	168	24	,	,	PUNCT
easat-2730	168	25	has	have	AUX
easat-2730	168	26	been	be	AUX
easat-2730	168	27	proposed	propose	VERB
easat-2730	168	28	as	as	ADP
easat-2730	168	29	one	one	NUM
easat-2730	168	30	of	of	ADP
easat-2730	168	31	several	several	ADJ
easat-2730	168	32	mechanisms	mechanism	NOUN
easat-2730	168	33	to	to	PART
easat-2730	168	34	explain	explain	VERB
easat-2730	168	35	enos	eno	NOUN
easat-2730	168	36	uncoupling	uncouple	VERB
easat-2730	168	37	[	[	PUNCT
easat-2730	168	38	33	33	NUM
easat-2730	168	39	]	]	PUNCT
easat-2730	168	40	.	.	PUNCT
easat-2730	169	1	in	in	ADP
easat-2730	169	2	particular	particular	ADJ
easat-2730	169	3	,	,	PUNCT
easat-2730	169	4	the	the	DET
easat-2730	169	5	increased	increase	VERB
easat-2730	169	6	production	production	NOUN
easat-2730	169	7	and	and	CCONJ
easat-2730	169	8	function	function	NOUN
easat-2730	169	9	of	of	ADP
easat-2730	169	10	the	the	DET
easat-2730	169	11	arginase	arginase	NOUN
easat-2730	169	12	isoforms	isoform	NOUN
easat-2730	169	13	(	(	PUNCT
easat-2730	169	14	arg	arg	VERB
easat-2730	169	15	i	i	PRON
easat-2730	169	16	and	and	CCONJ
easat-2730	169	17	arg	arg	PROPN
easat-2730	169	18	ii	ii	PROPN
easat-2730	169	19	)	)	PUNCT
easat-2730	169	20	are	be	AUX
easat-2730	169	21	responsible	responsible	ADJ
easat-2730	169	22	for	for	ADP
easat-2730	169	23	the	the	DET
easat-2730	169	24	decrease	decrease	NOUN
easat-2730	169	25	in	in	ADP
easat-2730	169	26	l	l	NOUN
easat-2730	169	27	-	-	NOUN
easat-2730	169	28	arginine	arginine	NOUN
easat-2730	169	29	.	.	PUNCT
easat-2730	170	1	alteration	alteration	NOUN
easat-2730	170	2	of	of	ADP
easat-2730	170	3	the	the	DET
easat-2730	170	4	enos	enos	PROPN
easat-2730	170	5	phosphorylation	phosphorylation	NOUN
easat-2730	170	6	status	status	NOUN
easat-2730	170	7	and	and	CCONJ
easat-2730	170	8	3448	3448	NUM
easat-2730	170	9	edelweiss	edelweiss	PROPN
easat-2730	170	10	applied	apply	VERB
easat-2730	170	11	science	science	NOUN
easat-2730	170	12	and	and	CCONJ
easat-2730	170	13	technology	technology	NOUN
easat-2730	170	14	issn	issn	PROPN
easat-2730	170	15	:	:	PUNCT
easat-2730	170	16	2576	2576	NUM
easat-2730	170	17	-	-	SYM
easat-2730	170	18	8484	8484	NUM
easat-2730	170	19	vol	vol	NOUN
easat-2730	170	20	.	.	PROPN
easat-2730	170	21	8	8	NUM
easat-2730	170	22	,	,	PUNCT
easat-2730	170	23	no	no	INTJ
easat-2730	170	24	.	.	NOUN
easat-2730	171	1	6	6	NUM
easat-2730	171	2	:	:	SYM
easat-2730	171	3	3441	3441	NUM
easat-2730	171	4	-	-	SYM
easat-2730	171	5	3456	3456	NUM
easat-2730	171	6	,	,	PUNCT
easat-2730	171	7	2024	2024	NUM
easat-2730	171	8	doi	doi	NOUN
easat-2730	171	9	:	:	PUNCT
easat-2730	171	10	10.55214/25768484.v8i6.2730	10.55214/25768484.v8i6.2730	NUM
easat-2730	171	11	©	©	ADP
easat-2730	171	12	2024	2024	NUM
easat-2730	171	13	by	by	ADP
easat-2730	171	14	the	the	DET
easat-2730	171	15	authors	author	NOUN
easat-2730	171	16	;	;	PUNCT
easat-2730	171	17	licensee	licensee	PROPN
easat-2730	171	18	learning	learn	VERB
easat-2730	171	19	gate	gate	NOUN
easat-2730	171	20	oxidative	oxidative	ADJ
easat-2730	171	21	stress	stress	NOUN
easat-2730	171	22	linked	link	VERB
easat-2730	171	23	with	with	ADP
easat-2730	171	24	enos	eno	NOUN
easat-2730	171	25	uncoupling	uncouple	VERB
easat-2730	171	26	are	be	AUX
easat-2730	171	27	the	the	DET
easat-2730	171	28	common	common	ADJ
easat-2730	171	29	characteristics	characteristic	NOUN
easat-2730	171	30	of	of	ADP
easat-2730	171	31	clinical	clinical	ADJ
easat-2730	171	32	conditions	condition	NOUN
easat-2730	171	33	linked	link	VERB
easat-2730	171	34	with	with	ADP
easat-2730	171	35	cvds	cvds	PROPN
easat-2730	171	36	,	,	PUNCT
easat-2730	171	37	including	include	VERB
easat-2730	171	38	dm	dm	NOUN
easat-2730	171	39	,	,	PUNCT
easat-2730	171	40	hypertension	hypertension	NOUN
easat-2730	171	41	,	,	PUNCT
easat-2730	171	42	atherosclerosis	atherosclerosis	NOUN
easat-2730	171	43	,	,	PUNCT
easat-2730	171	44	and	and	CCONJ
easat-2730	171	45	cerebral	cerebral	ADJ
easat-2730	171	46	ischemia	ischemia	NOUN
easat-2730	171	47	(	(	PUNCT
easat-2730	171	48	figure	figure	NOUN
easat-2730	171	49	3	3	NUM
easat-2730	171	50	)	)	PUNCT
easat-2730	172	1	[	[	X
easat-2730	172	2	9	9	NUM
easat-2730	172	3	]	]	PUNCT
easat-2730	172	4	.	.	PUNCT
easat-2730	173	1	figure	figure	NOUN
easat-2730	173	2	3	3	NUM
easat-2730	173	3	.	.	PUNCT
easat-2730	173	4	mechanism	mechanism	NOUN
easat-2730	173	5	of	of	ADP
easat-2730	173	6	oxidative	oxidative	ADJ
easat-2730	173	7	stress	stress	NOUN
easat-2730	173	8	-	-	PUNCT
easat-2730	173	9	induced	induce	VERB
easat-2730	173	10	endothelial	endothelial	ADJ
easat-2730	173	11	dysfunction	dysfunction	NOUN
easat-2730	173	12	.	.	PUNCT
easat-2730	174	1	increase	increase	NOUN
easat-2730	174	2	in	in	ADP
easat-2730	174	3	the	the	DET
easat-2730	174	4	oxidative	oxidative	ADJ
easat-2730	174	5	stress	stress	NOUN
easat-2730	174	6	caused	cause	VERB
easat-2730	174	7	enos	eno	NOUN
easat-2730	174	8	to	to	PART
easat-2730	174	9	lose	lose	VERB
easat-2730	174	10	its	its	PRON
easat-2730	174	11	physiological	physiological	ADJ
easat-2730	174	12	activities	activity	NOUN
easat-2730	174	13	,	,	PUNCT
easat-2730	174	14	a	a	DET
easat-2730	174	15	process	process	NOUN
easat-2730	174	16	termed	term	VERB
easat-2730	174	17	“	"	PUNCT
easat-2730	174	18	enos	enos	PROPN
easat-2730	174	19	uncoupling	uncouple	VERB
easat-2730	174	20	”	"	PUNCT
easat-2730	174	21	.	.	PUNCT
easat-2730	175	1	during	during	ADP
easat-2730	175	2	this	this	DET
easat-2730	175	3	situation	situation	NOUN
easat-2730	175	4	,	,	PUNCT
easat-2730	175	5	no	no	DET
easat-2730	175	6	reacts	react	NOUN
easat-2730	175	7	with	with	ADP
easat-2730	175	8	superoxide	superoxide	NOUN
easat-2730	175	9	to	to	PART
easat-2730	175	10	form	form	VERB
easat-2730	175	11	peroxynitrite	peroxynitrite	ADJ
easat-2730	175	12	(	(	PUNCT
easat-2730	175	13	onoo-	onoo-	SYM
easat-2730	175	14	)	)	PUNCT
easat-2730	175	15	,	,	PUNCT
easat-2730	175	16	a	a	DET
easat-2730	175	17	potent	potent	ADJ
easat-2730	175	18	inducers	inducer	NOUN
easat-2730	175	19	of	of	ADP
easat-2730	175	20	cell	cell	NOUN
easat-2730	175	21	death	death	NOUN
easat-2730	175	22	,	,	PUNCT
easat-2730	175	23	while	while	SCONJ
easat-2730	175	24	enos	eno	NOUN
easat-2730	175	25	produces	produce	VERB
easat-2730	175	26	ros	ros	PROPN
easat-2730	175	27	,	,	PUNCT
easat-2730	175	28	mostly	mostly	ADV
easat-2730	175	29	o2	o2	ADJ
easat-2730	175	30	,	,	PUNCT
easat-2730	175	31	rather	rather	ADV
easat-2730	175	32	than	than	ADP
easat-2730	175	33	no	no	PRON
easat-2730	175	34	.	.	PUNCT
easat-2730	176	1	hence	hence	ADV
easat-2730	176	2	,	,	PUNCT
easat-2730	176	3	enos	enos	PROPN
easat-2730	176	4	uncoupling	uncouple	VERB
easat-2730	176	5	leads	lead	VERB
easat-2730	176	6	to	to	PART
easat-2730	176	7	decrease	decrease	VERB
easat-2730	176	8	no	no	DET
easat-2730	176	9	bioavailability	bioavailability	NOUN
easat-2730	176	10	and	and	CCONJ
easat-2730	176	11	participates	participate	VERB
easat-2730	176	12	to	to	PART
easat-2730	176	13	further	far	ADV
easat-2730	176	14	progress	progress	VERB
easat-2730	176	15	the	the	DET
easat-2730	176	16	initiated	initiate	VERB
easat-2730	176	17	oxidative	oxidative	ADJ
easat-2730	176	18	stress	stress	NOUN
easat-2730	176	19	.	.	PUNCT
easat-2730	177	1	several	several	ADJ
easat-2730	177	2	mechanisms	mechanism	NOUN
easat-2730	177	3	have	have	AUX
easat-2730	177	4	been	be	AUX
easat-2730	177	5	recognised	recognise	VERB
easat-2730	177	6	to	to	PART
easat-2730	177	7	describe	describe	VERB
easat-2730	177	8	enos	eno	NOUN
easat-2730	177	9	uncoupling	uncouple	VERB
easat-2730	177	10	,	,	PUNCT
easat-2730	177	11	including	include	VERB
easat-2730	177	12	oxidation	oxidation	NOUN
easat-2730	177	13	of	of	ADP
easat-2730	177	14	bh4	bh4	NOUN
easat-2730	177	15	to	to	ADP
easat-2730	177	16	the	the	DET
easat-2730	177	17	inactive	inactive	ADJ
easat-2730	177	18	form	form	NOUN
easat-2730	177	19	by	by	ADP
easat-2730	177	20	onootogether	onootogether	NOUN
easat-2730	177	21	with	with	SCONJ
easat-2730	177	22	depletion	depletion	NOUN
easat-2730	177	23	of	of	ADP
easat-2730	177	24	l	l	NOUN
easat-2730	177	25	-	-	NOUN
easat-2730	177	26	arginine	arginine	NOUN
easat-2730	177	27	are	be	AUX
easat-2730	177	28	also	also	ADV
easat-2730	177	29	involved	involve	VERB
easat-2730	177	30	.	.	PUNCT
easat-2730	178	1	ros	ro	NOUN
easat-2730	178	2	;	;	PUNCT
easat-2730	178	3	reactive	reactive	ADJ
easat-2730	178	4	oxygen	oxygen	NOUN
easat-2730	178	5	species	specie	NOUN
easat-2730	178	6	,	,	PUNCT
easat-2730	178	7	enos	eno	NOUN
easat-2730	178	8	;	;	PUNCT
easat-2730	178	9	endothelial	endothelial	ADJ
easat-2730	178	10	nitric	nitric	ADJ
easat-2730	178	11	oxide	oxide	NOUN
easat-2730	178	12	synthase	synthase	NOUN
easat-2730	178	13	,	,	PUNCT
easat-2730	178	14	no	no	INTJ
easat-2730	178	15	;	;	PUNCT
easat-2730	178	16	nitric	nitric	ADJ
easat-2730	178	17	oxide	oxide	NOUN
easat-2730	178	18	.	.	PUNCT
easat-2730	179	1	3.2	3.2	NUM
easat-2730	179	2	.	.	PUNCT
easat-2730	179	3	dysfunctional	dysfunctional	ADJ
easat-2730	179	4	endothelium	endothelium	NOUN
easat-2730	179	5	and	and	CCONJ
easat-2730	179	6	the	the	DET
easat-2730	179	7	roles	role	NOUN
easat-2730	179	8	of	of	ADP
easat-2730	179	9	no	no	DET
easat-2730	179	10	the	the	DET
easat-2730	179	11	pathophysiology	pathophysiology	NOUN
easat-2730	179	12	of	of	ADP
easat-2730	179	13	various	various	ADJ
easat-2730	179	14	cvds	cvds	NOUN
easat-2730	179	15	,	,	PUNCT
easat-2730	179	16	such	such	ADJ
easat-2730	179	17	as	as	ADP
easat-2730	179	18	essential	essential	ADJ
easat-2730	179	19	hypertension	hypertension	NOUN
easat-2730	179	20	,	,	PUNCT
easat-2730	179	21	atherothrombosis	atherothrombosis	NOUN
easat-2730	179	22	,	,	PUNCT
easat-2730	179	23	and	and	CCONJ
easat-2730	179	24	preeclampsia	preeclampsia	NOUN
easat-2730	179	25	,	,	PUNCT
easat-2730	179	26	appears	appear	VERB
easat-2730	179	27	to	to	PART
easat-2730	179	28	be	be	AUX
easat-2730	179	29	profoundly	profoundly	ADV
easat-2730	179	30	associated	associate	VERB
easat-2730	179	31	with	with	ADP
easat-2730	179	32	dysfunctional	dysfunctional	ADJ
easat-2730	179	33	endothelial	endothelial	NOUN
easat-2730	179	34	no	no	DET
easat-2730	179	35	pathway	pathway	NOUN
easat-2730	179	36	.	.	PUNCT
easat-2730	180	1	the	the	DET
easat-2730	180	2	enos	enos	PROPN
easat-2730	180	3	catalyses	catalyse	VERB
easat-2730	180	4	the	the	DET
easat-2730	180	5	conversion	conversion	NOUN
easat-2730	180	6	of	of	ADP
easat-2730	180	7	no	no	PRON
easat-2730	180	8	from	from	ADP
easat-2730	180	9	the	the	DET
easat-2730	180	10	substrate	substrate	NOUN
easat-2730	180	11	l	l	NOUN
easat-2730	180	12	-	-	NOUN
easat-2730	180	13	arginine	arginine	NOUN
easat-2730	180	14	in	in	ADP
easat-2730	180	15	the	the	DET
easat-2730	180	16	vascular	vascular	ADJ
easat-2730	180	17	endothelium	endothelium	NOUN
easat-2730	180	18	.	.	PUNCT
easat-2730	181	1	this	this	DET
easat-2730	181	2	mediator	mediator	NOUN
easat-2730	181	3	affects	affect	VERB
easat-2730	181	4	the	the	DET
easat-2730	181	5	function	function	NOUN
easat-2730	181	6	of	of	ADP
easat-2730	181	7	circulating	circulate	VERB
easat-2730	181	8	cells	cell	NOUN
easat-2730	181	9	and	and	CCONJ
easat-2730	181	10	underlying	underlie	VERB
easat-2730	181	11	smooth	smooth	ADJ
easat-2730	181	12	muscle	muscle	NOUN
easat-2730	181	13	to	to	PART
easat-2730	181	14	support	support	VERB
easat-2730	181	15	the	the	DET
easat-2730	181	16	endothelial	endothelial	ADJ
easat-2730	181	17	tonic	tonic	NOUN
easat-2730	181	18	vasodilator	vasodilator	NOUN
easat-2730	181	19	,	,	PUNCT
easat-2730	181	20	thromboresistant	thromboresistant	ADJ
easat-2730	181	21	,	,	PUNCT
easat-2730	181	22	and	and	CCONJ
easat-2730	181	23	atheroprotective	atheroprotective	ADJ
easat-2730	181	24	effects	effect	NOUN
easat-2730	181	25	[	[	X
easat-2730	181	26	4	4	NUM
easat-2730	181	27	]	]	PUNCT
easat-2730	181	28	.	.	PUNCT
easat-2730	182	1	3.2.1	3.2.1	NUM
easat-2730	182	2	.	.	PUNCT
easat-2730	183	1	no	no	INTJ
easat-2730	183	2	and	and	CCONJ
easat-2730	183	3	inflammation	inflammation	NOUN
easat-2730	183	4	one	one	NUM
easat-2730	183	5	of	of	ADP
easat-2730	183	6	the	the	DET
easat-2730	183	7	primary	primary	ADJ
easat-2730	183	8	signs	sign	NOUN
easat-2730	183	9	of	of	ADP
easat-2730	183	10	inflammation	inflammation	NOUN
easat-2730	183	11	is	be	AUX
easat-2730	183	12	vasodilation	vasodilation	NOUN
easat-2730	183	13	,	,	PUNCT
easat-2730	183	14	which	which	PRON
easat-2730	183	15	is	be	AUX
easat-2730	183	16	basically	basically	ADV
easat-2730	183	17	triggered	trigger	VERB
easat-2730	183	18	by	by	ADP
easat-2730	183	19	a	a	DET
easat-2730	183	20	nodependent	nodependent	NOUN
easat-2730	183	21	mechanism	mechanism	NOUN
easat-2730	183	22	.	.	PUNCT
easat-2730	184	1	many	many	ADJ
easat-2730	184	2	inflammatory	inflammatory	ADJ
easat-2730	184	3	mediators	mediator	NOUN
easat-2730	184	4	,	,	PUNCT
easat-2730	184	5	including	include	VERB
easat-2730	184	6	bradykinin	bradykinin	NOUN
easat-2730	184	7	and	and	CCONJ
easat-2730	184	8	histamine	histamine	NOUN
easat-2730	184	9	,	,	PUNCT
easat-2730	184	10	stimulate	stimulate	VERB
easat-2730	184	11	endothelial	endothelial	ADJ
easat-2730	184	12	no	no	DET
easat-2730	184	13	release	release	NOUN
easat-2730	184	14	to	to	PART
easat-2730	184	15	cause	cause	VERB
easat-2730	184	16	vasodilation	vasodilation	NOUN
easat-2730	184	17	.	.	PUNCT
easat-2730	185	1	no	no	PRON
easat-2730	185	2	can	can	AUX
easat-2730	185	3	diffuse	diffuse	VERB
easat-2730	185	4	from	from	ADP
easat-2730	185	5	the	the	DET
easat-2730	185	6	endothelial	endothelial	ADJ
easat-2730	185	7	progenitor	progenitor	NOUN
easat-2730	185	8	cells	cell	NOUN
easat-2730	185	9	(	(	PUNCT
easat-2730	185	10	epcs	epc	NOUN
easat-2730	185	11	)	)	PUNCT
easat-2730	185	12	luminal	luminal	ADJ
easat-2730	185	13	and	and	CCONJ
easat-2730	185	14	abluminal	abluminal	ADJ
easat-2730	185	15	sides	side	NOUN
easat-2730	185	16	[	[	X
easat-2730	185	17	9	9	NUM
easat-2730	185	18	]	]	PUNCT
easat-2730	185	19	.	.	PUNCT
easat-2730	186	1	the	the	DET
easat-2730	186	2	no	no	NOUN
easat-2730	186	3	which	which	PRON
easat-2730	186	4	enters	enter	VERB
easat-2730	186	5	the	the	DET
easat-2730	186	6	vsm	vsm	PROPN
easat-2730	186	7	facilitates	facilitate	VERB
easat-2730	186	8	soluble	soluble	ADJ
easat-2730	186	9	guanylate	guanylate	NOUN
easat-2730	186	10	cyclase	cyclase	NOUN
easat-2730	186	11	,	,	PUNCT
easat-2730	186	12	resulting	result	VERB
easat-2730	186	13	to	to	ADP
easat-2730	186	14	an	an	DET
easat-2730	186	15	increase	increase	NOUN
easat-2730	186	16	in	in	ADP
easat-2730	186	17	intracellular	intracellular	ADJ
easat-2730	186	18	cgmp	cgmp	NOUN
easat-2730	186	19	levels	level	NOUN
easat-2730	186	20	,	,	PUNCT
easat-2730	186	21	causing	cause	VERB
easat-2730	186	22	smooth	smooth	ADJ
easat-2730	186	23	muscle	muscle	NOUN
easat-2730	186	24	relaxation	relaxation	NOUN
easat-2730	186	25	[	[	X
easat-2730	186	26	8	8	NUM
easat-2730	186	27	]	]	PUNCT
easat-2730	186	28	,	,	PUNCT
easat-2730	186	29	3449	3449	NUM
easat-2730	186	30	edelweiss	edelweiss	PROPN
easat-2730	186	31	applied	apply	VERB
easat-2730	186	32	science	science	NOUN
easat-2730	186	33	and	and	CCONJ
easat-2730	186	34	technology	technology	NOUN
easat-2730	186	35	issn	issn	PROPN
easat-2730	186	36	:	:	PUNCT
easat-2730	186	37	2576	2576	NUM
easat-2730	186	38	-	-	SYM
easat-2730	186	39	8484	8484	NUM
easat-2730	186	40	vol	vol	NOUN
easat-2730	186	41	.	.	PROPN
easat-2730	187	1	8	8	NUM
easat-2730	187	2	,	,	PUNCT
easat-2730	187	3	no	no	INTJ
easat-2730	187	4	.	.	NOUN
easat-2730	188	1	6	6	NUM
easat-2730	188	2	:	:	SYM
easat-2730	188	3	3441	3441	NUM
easat-2730	188	4	-	-	SYM
easat-2730	188	5	3456	3456	NUM
easat-2730	188	6	,	,	PUNCT
easat-2730	188	7	2024	2024	NUM
easat-2730	188	8	doi	doi	NOUN
easat-2730	188	9	:	:	PUNCT
easat-2730	188	10	10.55214/25768484.v8i6.2730	10.55214/25768484.v8i6.2730	NUM
easat-2730	188	11	©	©	ADP
easat-2730	188	12	2024	2024	NUM
easat-2730	188	13	by	by	ADP
easat-2730	188	14	the	the	DET
easat-2730	188	15	authors	author	NOUN
easat-2730	188	16	;	;	PUNCT
easat-2730	188	17	licensee	licensee	PROPN
easat-2730	188	18	learning	learning	NOUN
easat-2730	188	19	gate	gate	NOUN
easat-2730	188	20	while	while	SCONJ
easat-2730	188	21	the	the	DET
easat-2730	188	22	no	no	NOUN
easat-2730	188	23	which	which	PRON
easat-2730	188	24	enters	enter	VERB
easat-2730	188	25	the	the	DET
easat-2730	188	26	blood	blood	NOUN
easat-2730	188	27	vessel	vessel	NOUN
easat-2730	188	28	is	be	AUX
easat-2730	188	29	rapidly	rapidly	ADV
easat-2730	188	30	deactivated	deactivate	VERB
easat-2730	188	31	by	by	ADP
easat-2730	188	32	the	the	DET
easat-2730	188	33	interaction	interaction	NOUN
easat-2730	188	34	with	with	ADP
easat-2730	188	35	oxyhaemoglobin	oxyhaemoglobin	NOUN
easat-2730	188	36	.	.	PUNCT
easat-2730	189	1	superoxide	superoxide	NOUN
easat-2730	189	2	dismutase	dismutase	NOUN
easat-2730	189	3	(	(	PUNCT
easat-2730	189	4	sod	sod	NOUN
easat-2730	189	5	)	)	PUNCT
easat-2730	189	6	can	can	AUX
easat-2730	189	7	greatly	greatly	ADV
easat-2730	189	8	extend	extend	VERB
easat-2730	189	9	the	the	DET
easat-2730	189	10	lifespan	lifespan	NOUN
easat-2730	189	11	of	of	ADP
easat-2730	189	12	no	no	PRON
easat-2730	189	13	in	in	ADP
easat-2730	189	14	the	the	DET
easat-2730	189	15	blood	blood	NOUN
easat-2730	189	16	,	,	PUNCT
easat-2730	189	17	which	which	PRON
easat-2730	189	18	shows	show	VERB
easat-2730	189	19	that	that	SCONJ
easat-2730	189	20	no	no	PRON
easat-2730	189	21	is	be	AUX
easat-2730	189	22	also	also	ADV
easat-2730	189	23	inactivated	inactivate	VERB
easat-2730	189	24	through	through	ADP
easat-2730	189	25	interaction	interaction	NOUN
easat-2730	189	26	with	with	ADP
easat-2730	189	27	o2	o2	PROPN
easat-2730	189	28	[	[	X
easat-2730	189	29	9	9	NUM
easat-2730	189	30	]	]	PUNCT
easat-2730	189	31	,	,	PUNCT
easat-2730	189	32	since	since	SCONJ
easat-2730	189	33	the	the	DET
easat-2730	189	34	half	half	ADJ
easat-2730	189	35	-	-	PUNCT
easat-2730	189	36	life	life	NOUN
easat-2730	189	37	for	for	ADP
easat-2730	189	38	no	no	NOUN
easat-2730	189	39	in	in	ADP
easat-2730	189	40	the	the	DET
easat-2730	189	41	blood	blood	NOUN
easat-2730	189	42	is	be	AUX
easat-2730	189	43	typically	typically	ADV
easat-2730	189	44	recognised	recognise	VERB
easat-2730	189	45	within	within	ADP
easat-2730	189	46	a	a	DET
easat-2730	189	47	few	few	ADJ
easat-2730	189	48	seconds	second	NOUN
easat-2730	189	49	.	.	PUNCT
easat-2730	190	1	the	the	DET
easat-2730	190	2	endothelium	endothelium	NOUN
easat-2730	190	3	not	not	PART
easat-2730	190	4	only	only	ADV
easat-2730	190	5	transmits	transmit	VERB
easat-2730	190	6	vasodilatory	vasodilatory	ADJ
easat-2730	190	7	signals	signal	NOUN
easat-2730	190	8	but	but	CCONJ
easat-2730	190	9	also	also	ADV
easat-2730	190	10	functions	function	NOUN
easat-2730	190	11	as	as	ADP
easat-2730	190	12	a	a	DET
easat-2730	190	13	barrier	barrier	NOUN
easat-2730	190	14	to	to	PART
easat-2730	190	15	prevent	prevent	VERB
easat-2730	190	16	materials	material	NOUN
easat-2730	190	17	from	from	ADP
easat-2730	190	18	being	be	AUX
easat-2730	190	19	transported	transport	VERB
easat-2730	190	20	between	between	ADP
easat-2730	190	21	the	the	DET
easat-2730	190	22	interstitial	interstitial	NOUN
easat-2730	190	23	and	and	CCONJ
easat-2730	190	24	lumen	luman	NOUN
easat-2730	190	25	of	of	ADP
easat-2730	190	26	blood	blood	NOUN
easat-2730	190	27	arteries	artery	NOUN
easat-2730	191	1	[	[	X
easat-2730	191	2	34	34	NUM
easat-2730	191	3	]	]	PUNCT
easat-2730	191	4	.	.	PUNCT
easat-2730	192	1	no	no	PRON
easat-2730	192	2	plays	play	VERB
easat-2730	192	3	a	a	DET
easat-2730	192	4	role	role	NOUN
easat-2730	192	5	in	in	ADP
easat-2730	192	6	regulating	regulate	VERB
easat-2730	192	7	the	the	DET
easat-2730	192	8	permeability	permeability	NOUN
easat-2730	192	9	of	of	ADP
easat-2730	192	10	this	this	DET
easat-2730	192	11	barrier	barrier	NOUN
easat-2730	192	12	,	,	PUNCT
easat-2730	192	13	that	that	PRON
easat-2730	192	14	is	be	AUX
easat-2730	192	15	essential	essential	ADJ
easat-2730	192	16	for	for	ADP
easat-2730	192	17	homeostatic	homeostatic	ADJ
easat-2730	192	18	equilibrium	equilibrium	NOUN
easat-2730	192	19	.	.	PUNCT
easat-2730	193	1	because	because	SCONJ
easat-2730	193	2	no	no	PRON
easat-2730	193	3	reduces	reduce	VERB
easat-2730	193	4	endothelial	endothelial	ADJ
easat-2730	193	5	permeability	permeability	NOUN
easat-2730	193	6	,	,	PUNCT
easat-2730	193	7	its	its	PRON
easat-2730	193	8	effects	effect	NOUN
easat-2730	193	9	on	on	ADP
easat-2730	193	10	vascular	vascular	ADJ
easat-2730	193	11	permeability	permeability	NOUN
easat-2730	193	12	seem	seem	VERB
easat-2730	193	13	as	as	SCONJ
easat-2730	193	14	primarily	primarily	ADV
easat-2730	193	15	antiinflammatory	antiinflammatory	NOUN
easat-2730	193	16	[	[	X
easat-2730	193	17	35	35	NUM
easat-2730	193	18	]	]	PUNCT
easat-2730	193	19	.	.	PUNCT
easat-2730	194	1	initially	initially	ADV
easat-2730	194	2	,	,	PUNCT
easat-2730	194	3	for	for	ADP
easat-2730	194	4	the	the	DET
easat-2730	194	5	mobilization	mobilization	NOUN
easat-2730	194	6	of	of	ADP
easat-2730	194	7	a	a	DET
easat-2730	194	8	leukocyte	leukocyte	NOUN
easat-2730	194	9	to	to	ADP
easat-2730	194	10	the	the	DET
easat-2730	194	11	site	site	NOUN
easat-2730	194	12	of	of	ADP
easat-2730	194	13	injury	injury	NOUN
easat-2730	194	14	or	or	CCONJ
easat-2730	194	15	infection	infection	NOUN
easat-2730	194	16	,	,	PUNCT
easat-2730	194	17	the	the	DET
easat-2730	194	18	leukocytes	leukocyte	NOUN
easat-2730	194	19	must	must	AUX
easat-2730	194	20	be	be	AUX
easat-2730	194	21	"	"	PUNCT
easat-2730	194	22	trapped	trap	VERB
easat-2730	194	23	"	"	PUNCT
easat-2730	194	24	to	to	PART
easat-2730	194	25	establish	establish	VERB
easat-2730	194	26	contact	contact	NOUN
easat-2730	194	27	with	with	ADP
easat-2730	194	28	endothelium	endothelium	NOUN
easat-2730	194	29	.	.	PUNCT
easat-2730	195	1	this	this	PRON
easat-2730	195	2	is	be	AUX
easat-2730	195	3	achieved	achieve	VERB
easat-2730	195	4	by	by	ADP
easat-2730	195	5	up	up	ADJ
easat-2730	195	6	-	-	PUNCT
easat-2730	195	7	regulation	regulation	NOUN
easat-2730	195	8	of	of	ADP
easat-2730	195	9	p	p	NOUN
easat-2730	195	10	-	-	PUNCT
easat-2730	195	11	selectins	selectin	NOUN
easat-2730	195	12	,	,	PUNCT
easat-2730	195	13	a	a	DET
easat-2730	195	14	family	family	NOUN
easat-2730	195	15	of	of	ADP
easat-2730	195	16	adhesion	adhesion	NOUN
easat-2730	195	17	molecules	molecule	NOUN
easat-2730	195	18	,	,	PUNCT
easat-2730	195	19	which	which	PRON
easat-2730	195	20	is	be	AUX
easat-2730	195	21	located	locate	VERB
easat-2730	195	22	in	in	ADP
easat-2730	195	23	weibel	weibel	NOUN
easat-2730	195	24	-	-	PUNCT
easat-2730	195	25	palade	palade	NOUN
easat-2730	195	26	bodies	body	NOUN
easat-2730	195	27	in	in	ADP
easat-2730	195	28	the	the	DET
easat-2730	195	29	cytoplasm	cytoplasm	NOUN
easat-2730	195	30	of	of	ADP
easat-2730	195	31	ecs	ecs	PROPN
easat-2730	195	32	.	.	PUNCT
easat-2730	196	1	the	the	DET
easat-2730	196	2	leukocytes	leukocyte	NOUN
easat-2730	196	3	move	move	VERB
easat-2730	196	4	continuously	continuously	ADV
easat-2730	196	5	in	in	ADP
easat-2730	196	6	the	the	DET
easat-2730	196	7	blood	blood	NOUN
easat-2730	196	8	vessel	vessel	NOUN
easat-2730	196	9	because	because	SCONJ
easat-2730	196	10	of	of	ADP
easat-2730	196	11	the	the	DET
easat-2730	196	12	relatively	relatively	ADV
easat-2730	196	13	low	low	ADJ
easat-2730	196	14	-	-	PUNCT
easat-2730	196	15	affinity	affinity	NOUN
easat-2730	196	16	binding	binding	NOUN
easat-2730	196	17	,	,	PUNCT
easat-2730	196	18	which	which	PRON
easat-2730	196	19	has	have	AUX
easat-2730	196	20	been	be	AUX
easat-2730	196	21	explained	explain	VERB
easat-2730	196	22	as	as	ADP
easat-2730	196	23	"	"	PUNCT
easat-2730	196	24	rolling	roll	VERB
easat-2730	196	25	"	"	PUNCT
easat-2730	196	26	within	within	ADP
easat-2730	196	27	the	the	DET
easat-2730	196	28	endothelium	endothelium	NOUN
easat-2730	196	29	.	.	PUNCT
easat-2730	197	1	the	the	DET
easat-2730	197	2	momentum	momentum	NOUN
easat-2730	197	3	of	of	ADP
easat-2730	197	4	the	the	DET
easat-2730	197	5	leukocyte	leukocyte	NOUN
easat-2730	197	6	is	be	AUX
easat-2730	197	7	drastically	drastically	ADV
easat-2730	197	8	decreased	decrease	VERB
easat-2730	197	9	to	to	PART
easat-2730	197	10	interact	interact	VERB
easat-2730	197	11	with	with	ADP
easat-2730	197	12	the	the	DET
easat-2730	197	13	endothelial	endothelial	NOUN
easat-2730	197	14	integrins	integrin	NOUN
easat-2730	197	15	,	,	PUNCT
easat-2730	197	16	such	such	ADJ
easat-2730	197	17	as	as	ADP
easat-2730	197	18	icam-1	icam-1	NUM
easat-2730	197	19	through	through	ADP
easat-2730	197	20	the	the	DET
easat-2730	197	21	cd11	cd11	PROPN
easat-2730	197	22	/	/	SYM
easat-2730	197	23	cd18	cd18	PROPN
easat-2730	197	24	family	family	NOUN
easat-2730	197	25	of	of	ADP
easat-2730	197	26	adhesion	adhesion	NOUN
easat-2730	197	27	molecules	molecule	NOUN
easat-2730	197	28	.	.	PUNCT
easat-2730	198	1	the	the	DET
easat-2730	198	2	expression	expression	NOUN
easat-2730	198	3	of	of	ADP
easat-2730	198	4	p	p	NOUN
easat-2730	198	5	-	-	PUNCT
easat-2730	198	6	selectin	selectin	NOUN
easat-2730	198	7	appears	appear	VERB
easat-2730	198	8	to	to	PART
easat-2730	198	9	be	be	AUX
easat-2730	198	10	significantly	significantly	ADV
easat-2730	198	11	regulated	regulate	VERB
easat-2730	198	12	by	by	ADP
easat-2730	198	13	no	no	PRON
easat-2730	198	14	[	[	NOUN
easat-2730	198	15	8	8	NUM
easat-2730	198	16	]	]	PUNCT
easat-2730	198	17	.	.	PUNCT
easat-2730	199	1	p	p	X
easat-2730	199	2	-	-	PUNCT
easat-2730	199	3	selectin	selectin	ADJ
easat-2730	199	4	expression	expression	NOUN
easat-2730	199	5	is	be	AUX
easat-2730	199	6	increased	increase	VERB
easat-2730	199	7	by	by	ADP
easat-2730	199	8	inhibitors	inhibitor	NOUN
easat-2730	199	9	of	of	ADP
easat-2730	199	10	no	no	DET
easat-2730	199	11	synthase	synthase	NOUN
easat-2730	199	12	,	,	PUNCT
easat-2730	199	13	while	while	SCONJ
easat-2730	199	14	p	p	NOUN
easat-2730	199	15	-	-	PUNCT
easat-2730	199	16	selectin	selectin	ADJ
easat-2730	199	17	expression	expression	NOUN
easat-2730	199	18	is	be	AUX
easat-2730	199	19	decreased	decrease	VERB
easat-2730	199	20	by	by	ADP
easat-2730	199	21	no	no	INTJ
easat-2730	199	22	,	,	PUNCT
easat-2730	199	23	which	which	PRON
easat-2730	199	24	results	result	VERB
easat-2730	199	25	in	in	ADP
easat-2730	199	26	increased	increase	VERB
easat-2730	199	27	leukocyte	leukocyte	NOUN
easat-2730	199	28	adhesion	adhesion	NOUN
easat-2730	199	29	to	to	ADP
easat-2730	199	30	the	the	DET
easat-2730	199	31	endothelium	endothelium	NOUN
easat-2730	199	32	[	[	X
easat-2730	199	33	36	36	NUM
easat-2730	199	34	]	]	PUNCT
easat-2730	199	35	.	.	PUNCT
easat-2730	200	1	leukocyte	leukocyte	NOUN
easat-2730	200	2	infiltration	infiltration	NOUN
easat-2730	200	3	at	at	ADP
easat-2730	200	4	the	the	DET
easat-2730	200	5	site	site	NOUN
easat-2730	200	6	of	of	ADP
easat-2730	200	7	injury	injury	NOUN
easat-2730	200	8	or	or	CCONJ
easat-2730	200	9	infection	infection	NOUN
easat-2730	200	10	is	be	AUX
easat-2730	200	11	a	a	DET
easat-2730	200	12	defining	define	VERB
easat-2730	200	13	characteristic	characteristic	NOUN
easat-2730	200	14	of	of	ADP
easat-2730	200	15	inflammation	inflammation	NOUN
easat-2730	200	16	that	that	PRON
easat-2730	200	17	could	could	AUX
easat-2730	200	18	lead	lead	VERB
easat-2730	200	19	to	to	ADP
easat-2730	200	20	endothelial	endothelial	ADJ
easat-2730	200	21	dysfunction	dysfunction	NOUN
easat-2730	200	22	induced	induce	VERB
easat-2730	200	23	by	by	ADP
easat-2730	200	24	obesity	obesity	NOUN
easat-2730	200	25	and	and	CCONJ
easat-2730	200	26	is	be	AUX
easat-2730	200	27	significantly	significantly	ADV
easat-2730	200	28	influenced	influence	VERB
easat-2730	200	29	by	by	ADP
easat-2730	200	30	no	no	PRON
easat-2730	200	31	.	.	PUNCT
easat-2730	201	1	leukocyte	leukocyte	ADJ
easat-2730	201	2	adhesion	adhesion	NOUN
easat-2730	201	3	to	to	ADP
easat-2730	201	4	the	the	DET
easat-2730	201	5	endothelium	endothelium	NOUN
easat-2730	201	6	is	be	AUX
easat-2730	201	7	intensely	intensely	ADV
easat-2730	201	8	increased	increase	VERB
easat-2730	201	9	when	when	SCONJ
easat-2730	201	10	no	no	DET
easat-2730	201	11	generation	generation	NOUN
easat-2730	201	12	is	be	AUX
easat-2730	201	13	inhibited	inhibit	VERB
easat-2730	201	14	,	,	PUNCT
easat-2730	201	15	which	which	PRON
easat-2730	201	16	promotes	promote	VERB
easat-2730	201	17	endothelial	endothelial	ADJ
easat-2730	201	18	dysfunction	dysfunction	NOUN
easat-2730	202	1	[	[	X
easat-2730	202	2	36	36	NUM
easat-2730	202	3	]	]	PUNCT
easat-2730	202	4	,	,	PUNCT
easat-2730	202	5	whereas	whereas	SCONJ
easat-2730	202	6	no	no	PRON
easat-2730	202	7	can	can	AUX
easat-2730	202	8	significantly	significantly	ADV
easat-2730	202	9	reduce	reduce	VERB
easat-2730	202	10	leukocyte	leukocyte	NOUN
easat-2730	202	11	adhesion	adhesion	NOUN
easat-2730	202	12	to	to	ADP
easat-2730	202	13	the	the	DET
easat-2730	202	14	vascular	vascular	ADJ
easat-2730	202	15	endothelium	endothelium	NOUN
easat-2730	202	16	in	in	ADP
easat-2730	202	17	response	response	NOUN
easat-2730	202	18	to	to	PART
easat-2730	202	19	stimulation	stimulation	VERB
easat-2730	202	20	through	through	ADP
easat-2730	202	21	a	a	DET
easat-2730	202	22	chemotactic	chemotactic	ADJ
easat-2730	202	23	agent	agent	NOUN
easat-2730	202	24	(	(	PUNCT
easat-2730	202	25	fig	fig	NOUN
easat-2730	202	26	.	.	PUNCT
easat-2730	203	1	4	4	NUM
easat-2730	203	2	)	)	PUNCT
easat-2730	203	3	.	.	PUNCT
easat-2730	204	1	furthermore	furthermore	ADV
easat-2730	204	2	,	,	PUNCT
easat-2730	204	3	no	no	PRON
easat-2730	204	4	may	may	AUX
easat-2730	204	5	inhibit	inhibit	VERB
easat-2730	204	6	neutrophil	neutrophil	ADJ
easat-2730	204	7	aggregation	aggregation	NOUN
easat-2730	204	8	and	and	CCONJ
easat-2730	204	9	generation	generation	NOUN
easat-2730	204	10	,	,	PUNCT
easat-2730	204	11	preventing	prevent	VERB
easat-2730	204	12	it	it	PRON
easat-2730	204	13	from	from	ADP
easat-2730	204	14	injuryinduced	injuryinduce	VERB
easat-2730	204	15	by	by	ADP
easat-2730	204	16	the	the	DET
easat-2730	204	17	potent	potent	ADJ
easat-2730	204	18	reactive	reactive	ADJ
easat-2730	204	19	oxygen	oxygen	NOUN
easat-2730	204	20	metabolites	metabolite	NOUN
easat-2730	204	21	[	[	X
easat-2730	204	22	4	4	NUM
easat-2730	204	23	]	]	PUNCT
easat-2730	204	24	.	.	PUNCT
easat-2730	205	1	in	in	ADP
easat-2730	205	2	response	response	NOUN
easat-2730	205	3	to	to	PART
easat-2730	205	4	contact	contact	VERB
easat-2730	205	5	with	with	ADP
easat-2730	205	6	antigens	antigen	NOUN
easat-2730	205	7	,	,	PUNCT
easat-2730	205	8	bacterial	bacterial	ADJ
easat-2730	205	9	products	product	NOUN
easat-2730	205	10	,	,	PUNCT
easat-2730	205	11	or	or	CCONJ
easat-2730	205	12	several	several	ADJ
easat-2730	205	13	factors	factor	NOUN
easat-2730	205	14	,	,	PUNCT
easat-2730	205	15	mast	mast	NOUN
easat-2730	205	16	cells	cell	NOUN
easat-2730	205	17	secrete	secrete	VERB
easat-2730	205	18	a	a	DET
easat-2730	205	19	variety	variety	NOUN
easat-2730	205	20	of	of	ADP
easat-2730	205	21	chemical	chemical	NOUN
easat-2730	205	22	signals	signal	NOUN
easat-2730	205	23	,	,	PUNCT
easat-2730	205	24	such	such	ADJ
easat-2730	205	25	as	as	ADP
easat-2730	205	26	histamine	histamine	NOUN
easat-2730	205	27	,	,	PUNCT
easat-2730	205	28	serotonin	serotonin	VERB
easat-2730	205	29	,	,	PUNCT
easat-2730	205	30	platelet	platelet	NOUN
easat-2730	205	31	-	-	PUNCT
easat-2730	205	32	activating	activate	VERB
easat-2730	205	33	factor	factor	NOUN
easat-2730	205	34	(	(	PUNCT
easat-2730	205	35	paf	paf	PROPN
easat-2730	205	36	)	)	PUNCT
easat-2730	205	37	,	,	PUNCT
easat-2730	205	38	leukotrienes	leukotriene	NOUN
easat-2730	205	39	,	,	PUNCT
easat-2730	205	40	tnf	tnf	PROPN
easat-2730	205	41	,	,	PUNCT
easat-2730	205	42	heparin	heparin	NOUN
easat-2730	205	43	,	,	PUNCT
easat-2730	205	44	and	and	CCONJ
easat-2730	205	45	prostaglandins	prostaglandin	NOUN
easat-2730	205	46	.	.	PUNCT
easat-2730	206	1	these	these	PRON
easat-2730	206	2	indicated	indicate	VERB
easat-2730	206	3	that	that	SCONJ
easat-2730	206	4	mast	mast	NOUN
easat-2730	206	5	cells	cell	NOUN
easat-2730	206	6	are	be	AUX
easat-2730	206	7	crucial	crucial	ADJ
easat-2730	206	8	in	in	ADP
easat-2730	206	9	regulating	regulate	VERB
easat-2730	206	10	inflammatory	inflammatory	ADJ
easat-2730	206	11	responses	response	NOUN
easat-2730	206	12	.	.	PUNCT
easat-2730	207	1	mast	mast	NOUN
easat-2730	207	2	cells	cell	NOUN
easat-2730	207	3	serve	serve	VERB
easat-2730	207	4	to	to	PART
easat-2730	207	5	send	send	VERB
easat-2730	207	6	a	a	DET
easat-2730	207	7	signal	signal	NOUN
easat-2730	207	8	to	to	ADP
easat-2730	207	9	the	the	DET
easat-2730	207	10	immune	immune	ADJ
easat-2730	207	11	system	system	NOUN
easat-2730	207	12	when	when	SCONJ
easat-2730	207	13	foreign	foreign	ADJ
easat-2730	207	14	pathogens	pathogen	NOUN
easat-2730	207	15	or	or	CCONJ
easat-2730	207	16	toxic	toxic	ADJ
easat-2730	207	17	substances	substance	NOUN
easat-2730	207	18	are	be	AUX
easat-2730	207	19	present	present	ADJ
easat-2730	207	20	[	[	X
easat-2730	207	21	37	37	NUM
easat-2730	207	22	]	]	PUNCT
easat-2730	207	23	.	.	PUNCT
easat-2730	208	1	the	the	DET
easat-2730	208	2	activities	activity	NOUN
easat-2730	208	3	of	of	ADP
easat-2730	208	4	mast	mast	NOUN
easat-2730	208	5	cell	cell	NOUN
easat-2730	208	6	appear	appear	VERB
easat-2730	208	7	to	to	PART
easat-2730	208	8	be	be	AUX
easat-2730	208	9	controlled	control	VERB
easat-2730	208	10	by	by	ADP
easat-2730	208	11	no	no	INTJ
easat-2730	208	12	,	,	PUNCT
easat-2730	208	13	which	which	PRON
easat-2730	208	14	comes	come	VERB
easat-2730	208	15	either	either	CCONJ
easat-2730	208	16	from	from	ADP
easat-2730	208	17	another	another	DET
easat-2730	208	18	cellular	cellular	ADJ
easat-2730	208	19	source	source	NOUN
easat-2730	208	20	or	or	CCONJ
easat-2730	208	21	mast	mast	NOUN
easat-2730	208	22	cell	cell	NOUN
easat-2730	208	23	itself	itself	PRON
easat-2730	208	24	,	,	PUNCT
easat-2730	208	25	while	while	SCONJ
easat-2730	208	26	interleukin-1β	interleukin-1β	NOUN
easat-2730	208	27	(	(	PUNCT
easat-2730	208	28	il-1β	il-1β	PROPN
easat-2730	208	29	)	)	PUNCT
easat-2730	208	30	activation	activation	NOUN
easat-2730	208	31	can	can	AUX
easat-2730	208	32	significantly	significantly	ADV
easat-2730	208	33	increase	increase	VERB
easat-2730	208	34	the	the	DET
easat-2730	208	35	amount	amount	NOUN
easat-2730	208	36	of	of	ADP
easat-2730	208	37	no	no	DET
easat-2730	208	38	secret	secret	NOUN
easat-2730	208	39	from	from	ADP
easat-2730	208	40	mast	mast	NOUN
easat-2730	208	41	cells	cell	NOUN
easat-2730	209	1	[	[	X
easat-2730	209	2	9	9	NUM
easat-2730	209	3	]	]	PUNCT
easat-2730	209	4	.	.	PUNCT
easat-2730	210	1	the	the	DET
easat-2730	210	2	secretion	secretion	NOUN
easat-2730	210	3	of	of	ADP
easat-2730	210	4	several	several	ADJ
easat-2730	210	5	inflammatory	inflammatory	ADJ
easat-2730	210	6	mediators	mediator	NOUN
easat-2730	210	7	from	from	ADP
easat-2730	210	8	these	these	DET
easat-2730	210	9	cells	cell	NOUN
easat-2730	210	10	,	,	PUNCT
easat-2730	210	11	such	such	ADJ
easat-2730	210	12	as	as	ADP
easat-2730	210	13	histamine	histamine	NOUN
easat-2730	210	14	,	,	PUNCT
easat-2730	210	15	paf	paf	PROPN
easat-2730	210	16	,	,	PUNCT
easat-2730	210	17	and	and	CCONJ
easat-2730	210	18	tnf	tnf	PROPN
easat-2730	210	19	,	,	PUNCT
easat-2730	210	20	appears	appear	VERB
easat-2730	210	21	to	to	PART
easat-2730	210	22	be	be	AUX
easat-2730	210	23	down	down	ADV
easat-2730	210	24	-	-	PUNCT
easat-2730	210	25	regulated	regulate	VERB
easat-2730	210	26	by	by	ADP
easat-2730	210	27	the	the	DET
easat-2730	210	28	no	no	PRON
easat-2730	210	29	secreted	secrete	VERB
easat-2730	210	30	through	through	ADP
easat-2730	210	31	the	the	DET
easat-2730	210	32	mast	mast	NOUN
easat-2730	210	33	cell	cell	NOUN
easat-2730	210	34	,	,	PUNCT
easat-2730	210	35	which	which	PRON
easat-2730	210	36	is	be	AUX
easat-2730	210	37	an	an	DET
easat-2730	210	38	interesting	interesting	ADJ
easat-2730	210	39	finding	finding	NOUN
easat-2730	210	40	.	.	PUNCT
easat-2730	211	1	also	also	ADV
easat-2730	211	2	,	,	PUNCT
easat-2730	211	3	the	the	DET
easat-2730	211	4	synthesis	synthesis	NOUN
easat-2730	211	5	of	of	ADP
easat-2730	211	6	no	no	PRON
easat-2730	211	7	by	by	ADP
easat-2730	211	8	mast	mast	NOUN
easat-2730	211	9	cells	cell	NOUN
easat-2730	211	10	can	can	AUX
easat-2730	211	11	lead	lead	VERB
easat-2730	211	12	to	to	ADP
easat-2730	211	13	a	a	DET
easat-2730	211	14	decrease	decrease	NOUN
easat-2730	211	15	in	in	ADP
easat-2730	211	16	the	the	DET
easat-2730	211	17	propensity	propensity	NOUN
easat-2730	211	18	of	of	ADP
easat-2730	211	19	these	these	DET
easat-2730	211	20	cells	cell	NOUN
easat-2730	211	21	to	to	PART
easat-2730	211	22	degranulate	degranulate	VERB
easat-2730	211	23	[	[	X
easat-2730	211	24	38	38	NUM
easat-2730	211	25	]	]	PUNCT
easat-2730	211	26	.	.	PUNCT
easat-2730	212	1	no	no	PRON
easat-2730	212	2	could	could	AUX
easat-2730	212	3	prevent	prevent	VERB
easat-2730	212	4	macrophages	macrophage	NOUN
easat-2730	212	5	from	from	ADP
easat-2730	212	6	producing	produce	VERB
easat-2730	212	7	a	a	DET
easat-2730	212	8	range	range	NOUN
easat-2730	212	9	of	of	ADP
easat-2730	212	10	immunomodulatory	immunomodulatory	ADJ
easat-2730	212	11	cytokines	cytokine	NOUN
easat-2730	212	12	,	,	PUNCT
easat-2730	212	13	including	include	VERB
easat-2730	212	14	il-12	il-12	PRON
easat-2730	212	15	and	and	CCONJ
easat-2730	212	16	il-1	il-1	PUNCT
easat-2730	212	17	and	and	CCONJ
easat-2730	212	18	it	it	PRON
easat-2730	212	19	can	can	AUX
easat-2730	212	20	also	also	ADV
easat-2730	212	21	control	control	VERB
easat-2730	212	22	how	how	SCONJ
easat-2730	212	23	macrophage	macrophage	ADJ
easat-2730	212	24	-	-	PUNCT
easat-2730	212	25	derived	derive	VERB
easat-2730	212	26	cytokines	cytokine	NOUN
easat-2730	212	27	affect	affect	VERB
easat-2730	212	28	target	target	NOUN
easat-2730	212	29	cells	cell	NOUN
easat-2730	212	30	.	.	PUNCT
easat-2730	213	1	according	accord	VERB
easat-2730	213	2	to	to	ADP
easat-2730	213	3	a	a	DET
easat-2730	213	4	previous	previous	ADJ
easat-2730	213	5	study	study	NOUN
easat-2730	213	6	,	,	PUNCT
easat-2730	213	7	administering	administer	VERB
easat-2730	213	8	aspirin	aspirin	NOUN
easat-2730	213	9	to	to	ADP
easat-2730	213	10	rats	rat	NOUN
easat-2730	213	11	led	lead	VERB
easat-2730	213	12	to	to	ADP
easat-2730	213	13	tnf	tnf	PROPN
easat-2730	213	14	-	-	PUNCT
easat-2730	213	15	dependent	dependent	ADJ
easat-2730	213	16	apoptosis	apoptosis	NOUN
easat-2730	213	17	of	of	ADP
easat-2730	213	18	cells	cell	NOUN
easat-2730	213	19	in	in	ADP
easat-2730	213	20	the	the	DET
easat-2730	213	21	stomach	stomach	NOUN
easat-2730	213	22	mucosa	mucosa	NOUN
easat-2730	213	23	.	.	PUNCT
easat-2730	214	1	it	it	PRON
easat-2730	214	2	has	have	AUX
easat-2730	214	3	been	be	AUX
easat-2730	214	4	investigated	investigate	VERB
easat-2730	214	5	that	that	SCONJ
easat-2730	214	6	an	an	DET
easat-2730	214	7	aspirin	aspirin	NOUN
easat-2730	214	8	derivative	derivative	NOUN
easat-2730	214	9	that	that	PRON
easat-2730	214	10	releases	release	VERB
easat-2730	214	11	no	no	PRON
easat-2730	214	12	can	can	AUX
easat-2730	214	13	significantly	significantly	ADV
easat-2730	214	14	lower	lower	VERB
easat-2730	214	15	apoptosis	apoptosis	NOUN
easat-2730	214	16	and	and	CCONJ
easat-2730	214	17	protect	protect	VERB
easat-2730	214	18	gastric	gastric	ADJ
easat-2730	214	19	chief	chief	ADJ
easat-2730	214	20	cells	cell	NOUN
easat-2730	214	21	from	from	ADP
easat-2730	214	22	tnf	tnf	PROPN
easat-2730	214	23	-	-	PUNCT
easat-2730	214	24	induced	induce	VERB
easat-2730	214	25	injury	injury	NOUN
easat-2730	214	26	triggered	trigger	VERB
easat-2730	214	27	by	by	ADP
easat-2730	214	28	cgmp	cgmp	NOUN
easat-2730	214	29	-	-	ADJ
easat-2730	214	30	dependent	dependent	ADJ
easat-2730	214	31	and	and	CCONJ
easat-2730	214	32	independent	independent	ADJ
easat-2730	214	33	mechanisms	mechanism	NOUN
easat-2730	214	34	[	[	X
easat-2730	214	35	8	8	NUM
easat-2730	214	36	]	]	PUNCT
easat-2730	214	37	.	.	PUNCT
easat-2730	215	1	platelets	platelet	NOUN
easat-2730	215	2	are	be	AUX
easat-2730	215	3	essential	essential	ADJ
easat-2730	215	4	for	for	ADP
easat-2730	215	5	inflammatory	inflammatory	ADJ
easat-2730	215	6	processes	process	NOUN
easat-2730	215	7	,	,	PUNCT
easat-2730	215	8	blood	blood	NOUN
easat-2730	215	9	clotting	clotting	NOUN
easat-2730	215	10	and	and	CCONJ
easat-2730	215	11	thrombosis	thrombosis	NOUN
easat-2730	215	12	.	.	PUNCT
easat-2730	216	1	serotonin	serotonin	NOUN
easat-2730	216	2	,	,	PUNCT
easat-2730	216	3	thromboxane	thromboxane	NOUN
easat-2730	216	4	,	,	PUNCT
easat-2730	216	5	and	and	CCONJ
easat-2730	216	6	lipoxins	lipoxin	NOUN
easat-2730	216	7	,	,	PUNCT
easat-2730	216	8	are	be	AUX
easat-2730	216	9	among	among	ADP
easat-2730	216	10	other	other	ADJ
easat-2730	216	11	proinflammatory	proinflammatory	ADJ
easat-2730	216	12	mediators	mediator	NOUN
easat-2730	216	13	that	that	PRON
easat-2730	216	14	can	can	AUX
easat-2730	216	15	be	be	AUX
easat-2730	216	16	released	release	VERB
easat-2730	216	17	by	by	ADP
easat-2730	216	18	platelets	platelet	NOUN
easat-2730	216	19	.	.	PUNCT
easat-2730	217	1	vascular	vascular	ADJ
easat-2730	217	2	endothelial	endothelial	ADJ
easat-2730	217	3	growth	growth	NOUN
easat-2730	217	4	factor	factor	NOUN
easat-2730	217	5	(	(	PUNCT
easat-2730	217	6	vegf	vegf	PROPN
easat-2730	217	7	)	)	PUNCT
easat-2730	217	8	and	and	CCONJ
easat-2730	217	9	endostatin	endostatin	NOUN
easat-2730	217	10	are	be	AUX
easat-2730	217	11	among	among	ADP
easat-2730	217	12	the	the	DET
easat-2730	217	13	substances	substance	NOUN
easat-2730	217	14	present	present	ADJ
easat-2730	217	15	in	in	ADP
easat-2730	217	16	platelets	platelet	NOUN
easat-2730	217	17	that	that	PRON
easat-2730	217	18	can	can	AUX
easat-2730	217	19	regulate	regulate	VERB
easat-2730	217	20	the	the	DET
easat-2730	217	21	angiogenesis	angiogenesis	NOUN
easat-2730	217	22	(	(	PUNCT
easat-2730	217	23	development	development	NOUN
easat-2730	217	24	of	of	ADP
easat-2730	217	25	new	new	ADJ
easat-2730	217	26	blood	blood	NOUN
easat-2730	217	27	vessels	vessel	NOUN
easat-2730	217	28	)	)	PUNCT
easat-2730	217	29	process	process	NOUN
easat-2730	217	30	.	.	PUNCT
easat-2730	218	1	one	one	NUM
easat-2730	218	2	of	of	ADP
easat-2730	218	3	the	the	DET
easat-2730	218	4	strongest	strong	ADJ
easat-2730	218	5	pro	pro	ADJ
easat-2730	218	6	-	-	ADJ
easat-2730	218	7	angiogenic	angiogenic	ADJ
easat-2730	218	8	agents	agent	NOUN
easat-2730	218	9	is	be	AUX
easat-2730	218	10	vegf	vegf	NOUN
easat-2730	218	11	,	,	PUNCT
easat-2730	218	12	while	while	SCONJ
easat-2730	218	13	endostatin	endostatin	NOUN
easat-2730	218	14	is	be	AUX
easat-2730	218	15	a	a	DET
easat-2730	218	16	potent	potent	ADJ
easat-2730	218	17	inhibitor	inhibitor	NOUN
easat-2730	218	18	of	of	ADP
easat-2730	218	19	angiogenesis	angiogenesis	NOUN
easat-2730	219	1	[	[	X
easat-2730	219	2	34	34	NUM
easat-2730	219	3	,	,	PUNCT
easat-2730	219	4	38	38	NUM
easat-2730	219	5	]	]	PUNCT
easat-2730	219	6	.	.	PUNCT
easat-2730	220	1	many	many	ADJ
easat-2730	220	2	soluble	soluble	ADJ
easat-2730	220	3	mediators	mediator	NOUN
easat-2730	220	4	,	,	PUNCT
easat-2730	220	5	including	include	VERB
easat-2730	220	6	no	no	NOUN
easat-2730	220	7	,	,	PUNCT
easat-2730	220	8	regulate	regulate	VERB
easat-2730	220	9	platelet	platelet	NOUN
easat-2730	220	10	adhesion	adhesion	NOUN
easat-2730	220	11	and	and	CCONJ
easat-2730	220	12	aggregation	aggregation	NOUN
easat-2730	220	13	to	to	ADP
easat-2730	220	14	the	the	DET
easat-2730	220	15	vascular	vascular	ADJ
easat-2730	220	16	endothelium	endothelium	NOUN
easat-2730	220	17	.	.	PUNCT
easat-2730	221	1	therefore	therefore	ADV
easat-2730	221	2	,	,	PUNCT
easat-2730	221	3	no	no	PRON
easat-2730	221	4	exhibits	exhibit	VERB
easat-2730	221	5	a	a	DET
easat-2730	221	6	significant	significant	ADJ
easat-2730	221	7	role	role	NOUN
easat-2730	221	8	in	in	ADP
easat-2730	221	9	downregulating	downregulate	VERB
easat-2730	221	10	inflammatory	inflammatory	ADJ
easat-2730	221	11	processes	process	NOUN
easat-2730	221	12	by	by	ADP
easat-2730	221	13	down	down	ADV
easat-2730	221	14	-	-	PUNCT
easat-2730	221	15	regulating	regulate	VERB
easat-2730	221	16	platelet	platelet	NOUN
easat-2730	221	17	aggregation	aggregation	NOUN
easat-2730	221	18	and	and	CCONJ
easat-2730	221	19	adhesion	adhesion	NOUN
easat-2730	221	20	(	(	PUNCT
easat-2730	221	21	fig	fig	NOUN
easat-2730	221	22	.	.	PUNCT
easat-2730	221	23	4	4	NUM
easat-2730	221	24	)	)	PUNCT
easat-2730	221	25	.	.	PUNCT
easat-2730	222	1	the	the	DET
easat-2730	222	2	proangiogenic	proangiogenic	ADJ
easat-2730	222	3	effects	effect	NOUN
easat-2730	222	4	of	of	ADP
easat-2730	222	5	vegf	vegf	PROPN
easat-2730	222	6	are	be	AUX
easat-2730	222	7	also	also	ADV
easat-2730	222	8	partially	partially	ADV
easat-2730	222	9	mediated	mediate	VERB
easat-2730	222	10	by	by	ADP
easat-2730	222	11	no	no	INTJ
easat-2730	222	12	,	,	PUNCT
easat-2730	222	13	which	which	PRON
easat-2730	222	14	has	have	VERB
easat-2730	222	15	an	an	DET
easat-2730	222	16	impact	impact	NOUN
easat-2730	222	17	on	on	ADP
easat-2730	222	18	tumour	tumour	NOUN
easat-2730	222	19	growth	growth	NOUN
easat-2730	222	20	and	and	CCONJ
easat-2730	222	21	repair	repair	NOUN
easat-2730	222	22	[	[	X
easat-2730	222	23	8	8	NUM
easat-2730	222	24	]	]	SYM
easat-2730	222	25	.	.	PUNCT
easat-2730	223	1	3450	3450	NUM
easat-2730	223	2	edelweiss	edelweiss	PROPN
easat-2730	223	3	applied	apply	VERB
easat-2730	223	4	science	science	NOUN
easat-2730	223	5	and	and	CCONJ
easat-2730	223	6	technology	technology	NOUN
easat-2730	223	7	issn	issn	PROPN
easat-2730	223	8	:	:	PUNCT
easat-2730	223	9	2576	2576	NUM
easat-2730	223	10	-	-	SYM
easat-2730	223	11	8484	8484	NUM
easat-2730	223	12	vol	vol	NOUN
easat-2730	223	13	.	.	PROPN
easat-2730	223	14	8	8	NUM
easat-2730	223	15	,	,	PUNCT
easat-2730	223	16	no	no	INTJ
easat-2730	223	17	.	.	NOUN
easat-2730	224	1	6	6	NUM
easat-2730	224	2	:	:	SYM
easat-2730	224	3	3441	3441	NUM
easat-2730	224	4	-	-	SYM
easat-2730	224	5	3456	3456	NUM
easat-2730	224	6	,	,	PUNCT
easat-2730	224	7	2024	2024	NUM
easat-2730	224	8	doi	doi	NOUN
easat-2730	224	9	:	:	PUNCT
easat-2730	224	10	10.55214/25768484.v8i6.2730	10.55214/25768484.v8i6.2730	NUM
easat-2730	224	11	©	©	ADP
easat-2730	224	12	2024	2024	NUM
easat-2730	224	13	by	by	ADP
easat-2730	224	14	the	the	DET
easat-2730	224	15	authors	author	NOUN
easat-2730	224	16	;	;	PUNCT
easat-2730	225	1	licensee	licensee	PROPN
easat-2730	225	2	learning	learn	VERB
easat-2730	225	3	gate	gate	NOUN
easat-2730	225	4	figure	figure	NOUN
easat-2730	225	5	4	4	NUM
easat-2730	225	6	.	.	PUNCT
easat-2730	225	7	possible	possible	ADJ
easat-2730	225	8	mechanisms	mechanism	NOUN
easat-2730	225	9	of	of	ADP
easat-2730	225	10	action	action	NOUN
easat-2730	225	11	of	of	ADP
easat-2730	225	12	no	no	PRON
easat-2730	225	13	on	on	ADP
easat-2730	225	14	obesity	obesity	NOUN
easat-2730	225	15	-	-	PUNCT
easat-2730	225	16	induced	induce	VERB
easat-2730	225	17	endothelial	endothelial	ADJ
easat-2730	225	18	dysfunction	dysfunction	NOUN
easat-2730	225	19	.	.	PUNCT
easat-2730	226	1	during	during	ADP
easat-2730	226	2	atherothrombosis	atherothrombosis	NOUN
easat-2730	226	3	,	,	PUNCT
easat-2730	226	4	monocytes	monocyte	NOUN
easat-2730	226	5	are	be	AUX
easat-2730	226	6	attached	attach	VERB
easat-2730	226	7	to	to	ADP
easat-2730	226	8	the	the	DET
easat-2730	226	9	endothelium	endothelium	NOUN
easat-2730	226	10	.	.	PUNCT
easat-2730	227	1	the	the	DET
easat-2730	227	2	endothelial	endothelial	ADJ
easat-2730	227	3	permeability	permeability	NOUN
easat-2730	227	4	allows	allow	VERB
easat-2730	227	5	the	the	DET
easat-2730	227	6	ldl	ldl	NOUN
easat-2730	227	7	particles	particle	NOUN
easat-2730	227	8	to	to	PART
easat-2730	227	9	penetrate	penetrate	VERB
easat-2730	227	10	and	and	CCONJ
easat-2730	227	11	enter	enter	VERB
easat-2730	227	12	the	the	DET
easat-2730	227	13	arterial	arterial	ADJ
easat-2730	227	14	wall	wall	NOUN
easat-2730	227	15	.	.	PUNCT
easat-2730	228	1	within	within	ADP
easat-2730	228	2	the	the	DET
easat-2730	228	3	endothelium	endothelium	NOUN
easat-2730	228	4	,	,	PUNCT
easat-2730	228	5	mature	mature	ADJ
easat-2730	228	6	monocytes	monocyte	NOUN
easat-2730	228	7	transform	transform	VERB
easat-2730	228	8	into	into	ADP
easat-2730	228	9	macrophages	macrophage	NOUN
easat-2730	228	10	and	and	CCONJ
easat-2730	228	11	engulf	engulf	VERB
easat-2730	228	12	the	the	DET
easat-2730	228	13	ldl	ldl	NOUN
easat-2730	228	14	particles	particle	NOUN
easat-2730	228	15	to	to	PART
easat-2730	228	16	generate	generate	VERB
easat-2730	228	17	foam	foam	ADJ
easat-2730	228	18	cells	cell	NOUN
easat-2730	228	19	.	.	PUNCT
easat-2730	229	1	the	the	DET
easat-2730	229	2	smcs	smcs	ADJ
easat-2730	229	3	transmigrate	transmigrate	NOUN
easat-2730	229	4	to	to	ADP
easat-2730	229	5	the	the	DET
easat-2730	229	6	tunica	tunica	PROPN
easat-2730	229	7	intima	intima	NOUN
easat-2730	229	8	.	.	PUNCT
easat-2730	230	1	the	the	DET
easat-2730	230	2	rupture	rupture	NOUN
easat-2730	230	3	of	of	ADP
easat-2730	230	4	the	the	DET
easat-2730	230	5	plaque	plaque	NOUN
easat-2730	230	6	fibrous	fibrous	ADJ
easat-2730	230	7	cap	cap	NOUN
easat-2730	230	8	leads	lead	VERB
easat-2730	230	9	to	to	ADP
easat-2730	230	10	the	the	DET
easat-2730	230	11	generation	generation	NOUN
easat-2730	230	12	of	of	ADP
easat-2730	230	13	atherothrombosis	atherothrombosis	NOUN
easat-2730	230	14	.	.	PUNCT
easat-2730	231	1	tf	tf	INTJ
easat-2730	231	2	;	;	PUNCT
easat-2730	231	3	tissue	tissue	NOUN
easat-2730	231	4	factor	factor	NOUN
easat-2730	231	5	,	,	PUNCT
easat-2730	231	6	plg	plg	NOUN
easat-2730	231	7	;	;	PUNCT
easat-2730	231	8	prostaglandin	prostaglandin	NOUN
easat-2730	231	9	,	,	PUNCT
easat-2730	231	10	tfpi	tfpi	ADJ
easat-2730	231	11	;	;	PUNCT
easat-2730	231	12	tissue	tissue	NOUN
easat-2730	231	13	factor	factor	NOUN
easat-2730	231	14	pathway	pathway	NOUN
easat-2730	231	15	inhibitor	inhibitor	NOUN
easat-2730	231	16	,	,	PUNCT
easat-2730	231	17	tafi	tafi	PROPN
easat-2730	231	18	;	;	PUNCT
easat-2730	231	19	thrombin	thrombin	NOUN
easat-2730	231	20	activatable	activatable	ADJ
easat-2730	231	21	fibrinolysis	fibrinolysis	NOUN
easat-2730	231	22	inhibitor	inhibitor	NOUN
easat-2730	231	23	,	,	PUNCT
easat-2730	231	24	enos	eno	VERB
easat-2730	231	25	;	;	PUNCT
easat-2730	231	26	endothelial	endothelial	ADJ
easat-2730	231	27	nitric	nitric	ADJ
easat-2730	231	28	oxide	oxide	NOUN
easat-2730	231	29	,	,	PUNCT
easat-2730	231	30	pai-1	pai-1	NUM
easat-2730	231	31	;	;	PUNCT
easat-2730	231	32	plasminogen	plasminogen	NOUN
easat-2730	231	33	activator	activator	NOUN
easat-2730	231	34	inhibitor	inhibitor	NOUN
easat-2730	231	35	,	,	PUNCT
easat-2730	231	36	t	t	PROPN
easat-2730	231	37	-	-	PUNCT
easat-2730	231	38	pa	pa	PROPN
easat-2730	231	39	;	;	PUNCT
easat-2730	231	40	tissue	tissue	NOUN
easat-2730	231	41	-	-	PUNCT
easat-2730	231	42	type	type	NOUN
easat-2730	231	43	plasminogen	plasminogen	NOUN
easat-2730	231	44	activator	activator	NOUN
easat-2730	231	45	,	,	PUNCT
easat-2730	231	46	α2	α2	PROPN
easat-2730	231	47	-	-	PUNCT
easat-2730	231	48	ap	ap	PROPN
easat-2730	231	49	;	;	PUNCT
easat-2730	231	50	α2	α2	NOUN
easat-2730	231	51	-	-	PUNCT
easat-2730	231	52	antiplasmin	antiplasmin	NOUN
easat-2730	231	53	,	,	PUNCT
easat-2730	231	54	mcp-1	mcp-1	NOUN
easat-2730	231	55	;	;	PUNCT
easat-2730	231	56	monocyte	monocyte	ADJ
easat-2730	231	57	chemoattractant	chemoattractant	PROPN
easat-2730	231	58	protein-1	protein-1	PROPN
easat-2730	231	59	.	.	PUNCT
easat-2730	231	60	3.2.2	3.2.2	NUM
easat-2730	231	61	.	.	PUNCT
easat-2730	232	1	no	no	INTJ
easat-2730	232	2	as	as	ADP
easat-2730	232	3	an	an	DET
easat-2730	232	4	antioxidant	antioxidant	NOUN
easat-2730	232	5	both	both	CCONJ
easat-2730	232	6	in	in	ADP
easat-2730	232	7	vitro	vitro	X
easat-2730	232	8	and	and	CCONJ
easat-2730	232	9	in	in	ADP
easat-2730	232	10	vivo	vivo	ADJ
easat-2730	232	11	studies	study	NOUN
easat-2730	232	12	have	have	AUX
easat-2730	232	13	shown	show	VERB
easat-2730	232	14	that	that	SCONJ
easat-2730	232	15	no	no	PRON
easat-2730	232	16	is	be	AUX
easat-2730	232	17	a	a	DET
easat-2730	232	18	free	free	ADJ
easat-2730	232	19	radical	radical	ADJ
easat-2730	232	20	scavenger	scavenger	NOUN
easat-2730	232	21	similar	similar	ADJ
easat-2730	232	22	to	to	ADP
easat-2730	232	23	o2	o2	PROPN
easat-2730	232	24	[	[	X
easat-2730	232	25	8	8	NUM
easat-2730	232	26	]	]	PUNCT
easat-2730	232	27	.	.	PUNCT
easat-2730	233	1	it	it	PRON
easat-2730	233	2	was	be	AUX
easat-2730	233	3	discovered	discover	VERB
easat-2730	233	4	that	that	SCONJ
easat-2730	233	5	administering	administer	VERB
easat-2730	233	6	no	no	DET
easat-2730	233	7	increased	increase	VERB
easat-2730	233	8	the	the	DET
easat-2730	233	9	antioxidant	antioxidant	NOUN
easat-2730	233	10	capability	capability	NOUN
easat-2730	233	11	of	of	ADP
easat-2730	233	12	the	the	DET
easat-2730	233	13	plasma	plasma	NOUN
easat-2730	233	14	by	by	ADP
easat-2730	233	15	twofold	twofold	NOUN
easat-2730	233	16	.	.	PUNCT
easat-2730	234	1	furthermore	furthermore	ADV
easat-2730	234	2	,	,	PUNCT
easat-2730	234	3	these	these	DET
easat-2730	234	4	no	no	DET
easat-2730	234	5	concentrations	concentration	NOUN
easat-2730	234	6	reduced	reduce	VERB
easat-2730	234	7	the	the	DET
easat-2730	234	8	reperfusion	reperfusion	NOUN
easat-2730	234	9	-	-	PUNCT
easat-2730	234	10	induced	induce	VERB
easat-2730	234	11	mucosal	mucosal	NOUN
easat-2730	234	12	damage	damage	NOUN
easat-2730	234	13	,	,	PUNCT
easat-2730	234	14	which	which	PRON
easat-2730	234	15	has	have	AUX
easat-2730	234	16	been	be	AUX
easat-2730	234	17	demonstrated	demonstrate	VERB
easat-2730	234	18	to	to	PART
easat-2730	234	19	be	be	AUX
easat-2730	234	20	mediated	mediate	VERB
easat-2730	234	21	by	by	ADP
easat-2730	234	22	reactive	reactive	ADJ
easat-2730	234	23	oxygen	oxygen	NOUN
easat-2730	234	24	metabolites	metabolite	NOUN
easat-2730	234	25	.	.	PUNCT
easat-2730	235	1	the	the	DET
easat-2730	235	2	exact	exact	ADJ
easat-2730	235	3	method	method	NOUN
easat-2730	235	4	by	by	ADP
easat-2730	235	5	which	which	PRON
easat-2730	235	6	no	no	DET
easat-2730	235	7	scavenges	scavenge	NOUN
easat-2730	235	8	o2	o2	PROPN
easat-2730	235	9	is	be	AUX
easat-2730	235	10	not	not	PART
easat-2730	235	11	known	know	VERB
easat-2730	235	12	.	.	PUNCT
easat-2730	236	1	it	it	PRON
easat-2730	236	2	is	be	AUX
easat-2730	236	3	probable	probable	ADJ
easat-2730	236	4	that	that	SCONJ
easat-2730	236	5	when	when	SCONJ
easat-2730	236	6	no	no	DET
easat-2730	236	7	production	production	NOUN
easat-2730	236	8	is	be	AUX
easat-2730	236	9	greater	great	ADJ
easat-2730	236	10	than	than	ADP
easat-2730	236	11	local	local	ADJ
easat-2730	236	12	o2	o2	ADJ
easat-2730	236	13	-	-	PUNCT
easat-2730	236	14	generation	generation	NOUN
easat-2730	236	15	,	,	PUNCT
easat-2730	236	16	onoo	onoo	PROPN
easat-2730	236	17	may	may	AUX
easat-2730	236	18	decompose	decompose	VERB
easat-2730	236	19	faster	fast	ADV
easat-2730	236	20	to	to	ADP
easat-2730	236	21	nitrate	nitrate	NOUN
easat-2730	236	22	and	and	CCONJ
easat-2730	236	23	nitrite	nitrite	NOUN
easat-2730	236	24	,	,	PUNCT
easat-2730	236	25	decreasing	decrease	VERB
easat-2730	236	26	tissue	tissue	NOUN
easat-2730	236	27	exposure	exposure	NOUN
easat-2730	236	28	to	to	ADP
easat-2730	236	29	onooand	onooand	NOUN
easat-2730	236	30	to	to	ADP
easat-2730	236	31	the	the	DET
easat-2730	236	32	ohthat	ohthat	NOUN
easat-2730	236	33	could	could	AUX
easat-2730	236	34	be	be	AUX
easat-2730	236	35	produced	produce	VERB
easat-2730	236	36	by	by	ADP
easat-2730	236	37	onoo-	onoo-	NOUN
easat-2730	236	38	.	.	PUNCT
easat-2730	237	1	the	the	DET
easat-2730	237	2	o2	o2	PROPN
easat-2730	237	3	is	be	AUX
easat-2730	237	4	a	a	DET
easat-2730	237	5	potent	potent	ADJ
easat-2730	237	6	modulator	modulator	NOUN
easat-2730	237	7	of	of	ADP
easat-2730	237	8	mast	mast	NOUN
easat-2730	237	9	cells	cell	NOUN
easat-2730	237	10	,	,	PUNCT
easat-2730	237	11	that	that	PRON
easat-2730	237	12	facilitates	facilitate	VERB
easat-2730	237	13	activation	activation	NOUN
easat-2730	237	14	and	and	CCONJ
easat-2730	237	15	degranulation	degranulation	NOUN
easat-2730	237	16	in	in	ADP
easat-2730	237	17	this	this	DET
easat-2730	237	18	content	content	NOUN
easat-2730	237	19	[	[	X
easat-2730	237	20	39	39	NUM
easat-2730	237	21	,	,	PUNCT
easat-2730	237	22	40	40	NUM
easat-2730	237	23	]	]	PUNCT
easat-2730	237	24	.	.	PUNCT
easat-2730	238	1	in	in	ADP
easat-2730	238	2	the	the	DET
easat-2730	238	3	previous	previous	ADJ
easat-2730	238	4	studies	study	NOUN
easat-2730	238	5	,	,	PUNCT
easat-2730	238	6	administering	administer	VERB
easat-2730	238	7	the	the	DET
easat-2730	238	8	superoxide	superoxide	NOUN
easat-2730	238	9	scavenger	scavenger	NOUN
easat-2730	238	10	superoxide	superoxide	NOUN
easat-2730	238	11	dismutase	dismutase	NOUN
easat-2730	238	12	significantly	significantly	ADV
easat-2730	238	13	reduced	reduce	VERB
easat-2730	238	14	the	the	DET
easat-2730	238	15	intestinal	intestinal	ADJ
easat-2730	238	16	epithelial	epithelial	ADJ
easat-2730	238	17	permeability	permeability	NOUN
easat-2730	238	18	,	,	PUNCT
easat-2730	238	19	facilitated	facilitate	VERB
easat-2730	238	20	by	by	ADP
easat-2730	238	21	the	the	DET
easat-2730	238	22	suppression	suppression	NOUN
easat-2730	238	23	of	of	ADP
easat-2730	238	24	no	no	DET
easat-2730	238	25	production	production	NOUN
easat-2730	238	26	.	.	PUNCT
easat-2730	239	1	thus	thus	ADV
easat-2730	239	2	,	,	PUNCT
easat-2730	239	3	it	it	PRON
easat-2730	239	4	was	be	AUX
easat-2730	239	5	proposed	propose	VERB
easat-2730	239	6	that	that	SCONJ
easat-2730	239	7	an	an	DET
easat-2730	239	8	accumulation	accumulation	NOUN
easat-2730	239	9	of	of	ADP
easat-2730	239	10	o2	o2	PROPN
easat-2730	239	11	occurred	occur	VERB
easat-2730	239	12	due	due	ADJ
easat-2730	239	13	to	to	ADP
easat-2730	239	14	decreased	decrease	VERB
easat-2730	239	15	no	no	ADV
easat-2730	239	16	after	after	SCONJ
easat-2730	239	17	no	no	DET
easat-2730	239	18	synthase	synthase	NOUN
easat-2730	239	19	inhibitor	inhibitor	NOUN
easat-2730	239	20	has	have	AUX
easat-2730	239	21	been	be	AUX
easat-2730	239	22	administered	administer	VERB
easat-2730	239	23	.	.	PUNCT
easat-2730	240	1	additionally	additionally	ADV
easat-2730	240	2	,	,	PUNCT
easat-2730	240	3	the	the	DET
easat-2730	240	4	presence	presence	NOUN
easat-2730	240	5	of	of	ADP
easat-2730	240	6	o2	o2	PROPN
easat-2730	240	7	may	may	AUX
easat-2730	240	8	promote	promote	VERB
easat-2730	240	9	mast	mast	NOUN
easat-2730	240	10	cell	cell	NOUN
easat-2730	240	11	activity	activity	NOUN
easat-2730	240	12	or	or	CCONJ
easat-2730	240	13	function	function	NOUN
easat-2730	240	14	,	,	PUNCT
easat-2730	240	15	increase	increase	VERB
easat-2730	240	16	epithelial	epithelial	ADJ
easat-2730	240	17	permeability	permeability	NOUN
easat-2730	240	18	,	,	PUNCT
easat-2730	240	19	and	and	CCONJ
easat-2730	240	20	act	act	VERB
easat-2730	240	21	as	as	ADP
easat-2730	240	22	a	a	DET
easat-2730	240	23	precursor	precursor	NOUN
easat-2730	240	24	to	to	ADP
easat-2730	240	25	the	the	DET
easat-2730	240	26	formation	formation	NOUN
easat-2730	240	27	of	of	ADP
easat-2730	240	28	the	the	DET
easat-2730	240	29	potent	potent	ADJ
easat-2730	240	30	reactive	reactive	ADJ
easat-2730	240	31	oxygen	oxygen	NOUN
easat-2730	240	32	metabolites	metabolite	NOUN
easat-2730	240	33	.	.	PUNCT
easat-2730	241	1	also	also	ADV
easat-2730	241	2	,	,	PUNCT
easat-2730	241	3	no	no	DET
easat-2730	241	4	acts	act	NOUN
easat-2730	241	5	as	as	ADP
easat-2730	241	6	a	a	DET
easat-2730	241	7	superoxide	superoxide	NOUN
easat-2730	241	8	scavenger	scavenger	NOUN
easat-2730	241	9	and	and	CCONJ
easat-2730	241	10	might	might	AUX
easat-2730	241	11	potentially	potentially	ADV
easat-2730	241	12	inhibit	inhibit	VERB
easat-2730	241	13	the	the	DET
easat-2730	241	14	formation	formation	NOUN
easat-2730	241	15	of	of	ADP
easat-2730	241	16	o2	o2	PROPN
easat-2730	241	17	.	.	PROPN
easat-2730	241	18	3451	3451	NUM
easat-2730	241	19	edelweiss	edelweiss	PROPN
easat-2730	241	20	applied	apply	VERB
easat-2730	241	21	science	science	NOUN
easat-2730	241	22	and	and	CCONJ
easat-2730	241	23	technology	technology	NOUN
easat-2730	241	24	issn	issn	PROPN
easat-2730	241	25	:	:	PUNCT
easat-2730	241	26	2576	2576	NUM
easat-2730	241	27	-	-	SYM
easat-2730	241	28	8484	8484	NUM
easat-2730	241	29	vol	vol	NOUN
easat-2730	241	30	.	.	PROPN
easat-2730	241	31	8	8	NUM
easat-2730	241	32	,	,	PUNCT
easat-2730	241	33	no	no	INTJ
easat-2730	241	34	.	.	NOUN
easat-2730	242	1	6	6	NUM
easat-2730	242	2	:	:	SYM
easat-2730	242	3	3441	3441	NUM
easat-2730	242	4	-	-	SYM
easat-2730	242	5	3456	3456	NUM
easat-2730	242	6	,	,	PUNCT
easat-2730	242	7	2024	2024	NUM
easat-2730	242	8	doi	doi	NOUN
easat-2730	242	9	:	:	PUNCT
easat-2730	242	10	10.55214/25768484.v8i6.2730	10.55214/25768484.v8i6.2730	NUM
easat-2730	242	11	©	©	ADP
easat-2730	242	12	2024	2024	NUM
easat-2730	242	13	by	by	ADP
easat-2730	242	14	the	the	DET
easat-2730	242	15	authors	author	NOUN
easat-2730	242	16	;	;	PUNCT
easat-2730	242	17	licensee	licensee	PROPN
easat-2730	242	18	learning	learning	NOUN
easat-2730	242	19	gate	gate	PROPN
easat-2730	242	20	previous	previous	ADJ
easat-2730	242	21	studies	study	NOUN
easat-2730	242	22	have	have	AUX
easat-2730	242	23	suggested	suggest	VERB
easat-2730	242	24	that	that	SCONJ
easat-2730	242	25	no	no	PRON
easat-2730	242	26	may	may	AUX
easat-2730	242	27	prevent	prevent	VERB
easat-2730	242	28	neutrophils	neutrophil	NOUN
easat-2730	242	29	from	from	ADP
easat-2730	242	30	producing	produce	VERB
easat-2730	242	31	o2	o2	PROPN
easat-2730	242	32	by	by	ADP
easat-2730	242	33	directly	directly	ADV
easat-2730	242	34	blocking	block	VERB
easat-2730	242	35	nadph	nadph	ADJ
easat-2730	242	36	oxidase	oxidase	NOUN
easat-2730	243	1	[	[	X
easat-2730	243	2	8	8	NUM
easat-2730	243	3	]	]	PUNCT
easat-2730	243	4	.	.	PUNCT
easat-2730	244	1	3.2.3	3.2.3	X
easat-2730	244	2	.	.	PUNCT
easat-2730	245	1	no	no	PRON
easat-2730	245	2	regulates	regulate	VERB
easat-2730	245	3	vasomotor	vasomotor	NOUN
easat-2730	245	4	tone	tone	NOUN
easat-2730	245	5	of	of	ADP
easat-2730	245	6	the	the	DET
easat-2730	245	7	endothelium	endothelium	NOUN
easat-2730	245	8	recent	recent	ADJ
easat-2730	245	9	study	study	NOUN
easat-2730	245	10	has	have	AUX
easat-2730	245	11	shown	show	VERB
easat-2730	245	12	that	that	SCONJ
easat-2730	245	13	endothelium	endothelium	NOUN
easat-2730	245	14	releases	release	VERB
easat-2730	245	15	no	no	PRON
easat-2730	245	16	to	to	PART
easat-2730	245	17	counteract	counteract	VERB
easat-2730	245	18	the	the	DET
easat-2730	245	19	intrinsic	intrinsic	ADJ
easat-2730	245	20	constrictive	constrictive	ADJ
easat-2730	245	21	properties	property	NOUN
easat-2730	245	22	of	of	ADP
easat-2730	245	23	acetylcholine	acetylcholine	NOUN
easat-2730	245	24	on	on	ADP
easat-2730	245	25	the	the	DET
easat-2730	245	26	vsm	vsm	PROPN
easat-2730	245	27	.	.	PUNCT
easat-2730	246	1	endothelial	endothelial	ADJ
easat-2730	246	2	dysfunction	dysfunction	NOUN
easat-2730	246	3	is	be	AUX
easat-2730	246	4	initiated	initiate	VERB
easat-2730	246	5	by	by	ADP
easat-2730	246	6	several	several	ADJ
easat-2730	246	7	pathophysiological	pathophysiological	ADJ
easat-2730	246	8	conditions	condition	NOUN
easat-2730	246	9	,	,	PUNCT
easat-2730	246	10	mostly	mostly	ADV
easat-2730	246	11	through	through	ADP
easat-2730	246	12	a	a	DET
easat-2730	246	13	reduction	reduction	NOUN
easat-2730	246	14	in	in	ADP
easat-2730	246	15	the	the	DET
easat-2730	246	16	endothelium	endothelium	NOUN
easat-2730	246	17	-	-	PUNCT
easat-2730	246	18	dependent	dependent	ADJ
easat-2730	246	19	vasodilation	vasodilation	NOUN
easat-2730	246	20	[	[	X
easat-2730	246	21	8	8	NUM
easat-2730	246	22	]	]	PUNCT
easat-2730	246	23	.	.	PUNCT
easat-2730	247	1	endothelial	endothelial	ADJ
easat-2730	247	2	dysfunction	dysfunction	NOUN
easat-2730	247	3	resulting	result	VERB
easat-2730	247	4	from	from	ADP
easat-2730	247	5	a	a	DET
easat-2730	247	6	block	block	NOUN
easat-2730	247	7	in	in	ADP
easat-2730	247	8	no	no	DET
easat-2730	247	9	secretion	secretion	NOUN
easat-2730	247	10	,	,	PUNCT
easat-2730	247	11	may	may	AUX
easat-2730	247	12	lead	lead	VERB
easat-2730	247	13	to	to	ADP
easat-2730	247	14	agonistic	agonistic	ADJ
easat-2730	247	15	activate	activate	VERB
easat-2730	247	16	smooth	smooth	ADJ
easat-2730	247	17	muscle	muscle	NOUN
easat-2730	247	18	receptors	receptor	NOUN
easat-2730	247	19	to	to	PART
easat-2730	247	20	cause	cause	VERB
easat-2730	247	21	vasoconstriction	vasoconstriction	NOUN
easat-2730	247	22	rather	rather	ADV
easat-2730	247	23	than	than	ADP
easat-2730	247	24	endothelium	endothelium	NOUN
easat-2730	247	25	-	-	PUNCT
easat-2730	247	26	dependent	dependent	ADJ
easat-2730	247	27	vasodilation	vasodilation	NOUN
easat-2730	247	28	.	.	PUNCT
easat-2730	248	1	increased	increase	VERB
easat-2730	248	2	intracellular	intracellular	ADJ
easat-2730	248	3	free	free	ADJ
easat-2730	248	4	ca2	ca2	PROPN
easat-2730	248	5	+	+	PROPN
easat-2730	248	6	in	in	ADP
easat-2730	248	7	vsmc	vsmc	NOUN
easat-2730	248	8	may	may	AUX
easat-2730	248	9	cause	cause	VERB
easat-2730	248	10	their	their	PRON
easat-2730	248	11	contraction	contraction	NOUN
easat-2730	248	12	.	.	PUNCT
easat-2730	249	1	the	the	DET
easat-2730	249	2	substantial	substantial	ADJ
easat-2730	249	3	vasorelaxant	vasorelaxant	ADJ
easat-2730	249	4	action	action	NOUN
easat-2730	249	5	of	of	ADP
easat-2730	249	6	no	no	DET
easat-2730	249	7	blocks	block	NOUN
easat-2730	249	8	this	this	DET
easat-2730	249	9	latter	latter	ADJ
easat-2730	249	10	effect	effect	NOUN
easat-2730	249	11	when	when	SCONJ
easat-2730	249	12	the	the	DET
easat-2730	249	13	endothelium	endothelium	NOUN
easat-2730	249	14	is	be	AUX
easat-2730	249	15	normal	normal	ADJ
easat-2730	249	16	.	.	PUNCT
easat-2730	250	1	numerous	numerous	ADJ
easat-2730	250	2	agonists	agonist	NOUN
easat-2730	250	3	,	,	PUNCT
easat-2730	250	4	including	include	VERB
easat-2730	250	5	acetylcholine	acetylcholine	NOUN
easat-2730	250	6	,	,	PUNCT
easat-2730	250	7	bradykinin	bradykinin	PROPN
easat-2730	250	8	,	,	PUNCT
easat-2730	250	9	serotonin	serotonin	VERB
easat-2730	250	10	,	,	PUNCT
easat-2730	250	11	adenosine	adenosine	NOUN
easat-2730	250	12	,	,	PUNCT
easat-2730	250	13	adp	adp	PROPN
easat-2730	250	14	,	,	PUNCT
easat-2730	250	15	atp	atp	PROPN
easat-2730	250	16	,	,	PUNCT
easat-2730	250	17	histamine	histamine	NOUN
easat-2730	250	18	,	,	PUNCT
easat-2730	250	19	and	and	CCONJ
easat-2730	250	20	thrombin	thrombin	NOUN
easat-2730	250	21	,	,	PUNCT
easat-2730	250	22	are	be	AUX
easat-2730	250	23	potent	potent	ADJ
easat-2730	250	24	in	in	ADP
easat-2730	250	25	this	this	DET
easat-2730	250	26	regard	regard	NOUN
easat-2730	250	27	.	.	PUNCT
easat-2730	251	1	even	even	ADV
easat-2730	251	2	angiotensin	angiotensin	PROPN
easat-2730	251	3	ii	ii	PROPN
easat-2730	251	4	induces	induce	VERB
easat-2730	251	5	macrovascular	macrovascular	ADJ
easat-2730	251	6	endothelium	endothelium	NOUN
easat-2730	251	7	to	to	PART
easat-2730	251	8	release	release	VERB
easat-2730	251	9	no	no	PRON
easat-2730	251	10	,	,	PUNCT
easat-2730	251	11	which	which	PRON
easat-2730	251	12	potentially	potentially	ADV
easat-2730	251	13	modulates	modulate	VERB
easat-2730	251	14	the	the	DET
easat-2730	251	15	vasoconstrictor	vasoconstrictor	NOUN
easat-2730	251	16	effects	effect	NOUN
easat-2730	251	17	of	of	ADP
easat-2730	251	18	angiotensin	angiotensin	NOUN
easat-2730	251	19	ii	ii	PROPN
easat-2730	251	20	on	on	ADP
easat-2730	251	21	vsmc	vsmc	NOUN
easat-2730	251	22	[	[	X
easat-2730	251	23	9	9	NUM
easat-2730	251	24	,	,	PUNCT
easat-2730	251	25	41	41	NUM
easat-2730	251	26	]	]	PUNCT
easat-2730	251	27	.	.	PUNCT
easat-2730	252	1	this	this	DET
easat-2730	252	2	advantageous	advantageous	ADJ
easat-2730	252	3	effect	effect	NOUN
easat-2730	252	4	might	might	AUX
easat-2730	252	5	be	be	AUX
easat-2730	252	6	negated	negate	VERB
easat-2730	252	7	by	by	ADP
easat-2730	252	8	the	the	DET
easat-2730	252	9	concurrent	concurrent	ADJ
easat-2730	252	10	formation	formation	NOUN
easat-2730	252	11	of	of	ADP
easat-2730	252	12	peroxynitrite	peroxynitrite	ADJ
easat-2730	252	13	(	(	PUNCT
easat-2730	252	14	onoo-	onoo-	SYM
easat-2730	252	15	)	)	PUNCT
easat-2730	252	16	,	,	PUNCT
easat-2730	252	17	which	which	PRON
easat-2730	252	18	might	might	AUX
easat-2730	252	19	contribute	contribute	VERB
easat-2730	252	20	to	to	ADP
easat-2730	252	21	various	various	ADJ
easat-2730	252	22	pathophysiological	pathophysiological	ADJ
easat-2730	252	23	activities	activity	NOUN
easat-2730	252	24	in	in	ADP
easat-2730	252	25	the	the	DET
easat-2730	252	26	vascular	vascular	ADJ
easat-2730	252	27	endothelial	endothelial	NOUN
easat-2730	252	28	wall	wall	NOUN
easat-2730	252	29	.	.	PUNCT
easat-2730	253	1	experimental	experimental	ADJ
easat-2730	253	2	evidence	evidence	NOUN
easat-2730	253	3	has	have	AUX
easat-2730	253	4	shown	show	VERB
easat-2730	253	5	the	the	DET
easat-2730	253	6	significance	significance	NOUN
easat-2730	253	7	of	of	ADP
easat-2730	253	8	no	no	PRON
easat-2730	253	9	as	as	ADP
easat-2730	253	10	a	a	DET
easat-2730	253	11	modulator	modulator	NOUN
easat-2730	253	12	of	of	ADP
easat-2730	253	13	endothelial	endothelial	ADJ
easat-2730	253	14	vasomotor	vasomotor	NOUN
easat-2730	253	15	tone	tone	NOUN
easat-2730	253	16	by	by	ADP
easat-2730	253	17	suppressing	suppress	VERB
easat-2730	253	18	its	its	PRON
easat-2730	253	19	generation	generation	NOUN
easat-2730	253	20	,	,	PUNCT
easat-2730	253	21	while	while	SCONJ
easat-2730	253	22	the	the	DET
easat-2730	253	23	l	l	NOUN
easat-2730	253	24	-	-	NOUN
easat-2730	253	25	guanidino	guanidino	NOUN
easat-2730	253	26	arginine	arginine	NOUN
easat-2730	253	27	group	group	NOUN
easat-2730	253	28	can	can	AUX
easat-2730	253	29	be	be	AUX
easat-2730	253	30	chemically	chemically	ADV
easat-2730	253	31	altered	alter	VERB
easat-2730	253	32	to	to	PART
easat-2730	253	33	produce	produce	VERB
easat-2730	253	34	substances	substance	NOUN
easat-2730	253	35	that	that	PRON
easat-2730	253	36	block	block	VERB
easat-2730	253	37	no	no	DET
easat-2730	253	38	synthase	synthase	NOUN
easat-2730	253	39	.	.	PUNCT
easat-2730	254	1	ng	ng	PROPN
easat-2730	254	2	-	-	PUNCT
easat-2730	254	3	monomethyl	monomethyl	NOUN
easat-2730	254	4	-	-	PUNCT
easat-2730	254	5	l	l	NOUN
easat-2730	254	6	-	-	NOUN
easat-2730	254	7	arginine	arginine	NOUN
easat-2730	254	8	(	(	PUNCT
easat-2730	254	9	l	l	NOUN
easat-2730	254	10	-	-	NOUN
easat-2730	254	11	nmma	nmma	NOUN
easat-2730	254	12	)	)	PUNCT
easat-2730	254	13	,	,	PUNCT
easat-2730	254	14	ng	ng	PROPN
easat-2730	254	15	-	-	PUNCT
easat-2730	254	16	nitro	nitro	NOUN
easat-2730	254	17	-	-	PUNCT
easat-2730	254	18	larginine	larginine	NOUN
easat-2730	254	19	(	(	PUNCT
easat-2730	254	20	l	l	NOUN
easat-2730	254	21	-	-	PUNCT
easat-2730	254	22	na	na	NOUN
easat-2730	254	23	)	)	PUNCT
easat-2730	254	24	,	,	PUNCT
easat-2730	254	25	and	and	CCONJ
easat-2730	254	26	ng	ng	PROPN
easat-2730	254	27	-	-	PUNCT
easat-2730	254	28	nitro	nitro	NOUN
easat-2730	254	29	-	-	PUNCT
easat-2730	254	30	l	l	NOUN
easat-2730	254	31	-	-	PUNCT
easat-2730	254	32	arginine	arginine	NOUN
easat-2730	254	33	methyl	methyl	NOUN
easat-2730	254	34	ester	ester	NOUN
easat-2730	254	35	(	(	PUNCT
easat-2730	254	36	l	l	NOUN
easat-2730	254	37	-	-	NOUN
easat-2730	254	38	name	name	NOUN
easat-2730	254	39	)	)	PUNCT
easat-2730	254	40	are	be	AUX
easat-2730	254	41	all	all	PRON
easat-2730	254	42	inhibitors	inhibitor	NOUN
easat-2730	254	43	of	of	ADP
easat-2730	254	44	no	no	DET
easat-2730	254	45	release	release	NOUN
easat-2730	254	46	from	from	ADP
easat-2730	254	47	ecs	ec	NOUN
easat-2730	254	48	and	and	CCONJ
easat-2730	254	49	aortic	aortic	ADJ
easat-2730	254	50	rings	ring	NOUN
easat-2730	254	51	,	,	PUNCT
easat-2730	254	52	demonstrating	demonstrate	VERB
easat-2730	254	53	that	that	SCONJ
easat-2730	254	54	no	no	PRON
easat-2730	254	55	is	be	AUX
easat-2730	254	56	continually	continually	ADV
easat-2730	254	57	released	release	VERB
easat-2730	254	58	from	from	ADP
easat-2730	254	59	these	these	DET
easat-2730	254	60	tissues	tissue	NOUN
easat-2730	254	61	,	,	PUNCT
easat-2730	254	62	which	which	PRON
easat-2730	254	63	maintain	maintain	VERB
easat-2730	254	64	the	the	DET
easat-2730	254	65	vasodilator	vasodilator	NOUN
easat-2730	254	66	tone	tone	NOUN
easat-2730	254	67	.	.	PUNCT
easat-2730	255	1	evidence	evidence	NOUN
easat-2730	255	2	has	have	AUX
easat-2730	255	3	shown	show	VERB
easat-2730	255	4	that	that	SCONJ
easat-2730	255	5	the	the	DET
easat-2730	255	6	blood	blood	NOUN
easat-2730	255	7	pressure	pressure	NOUN
easat-2730	255	8	of	of	ADP
easat-2730	255	9	rats	rat	NOUN
easat-2730	255	10	and	and	CCONJ
easat-2730	255	11	rabbits	rabbit	NOUN
easat-2730	255	12	increases	increase	VERB
easat-2730	255	13	in	in	ADP
easat-2730	255	14	vivo	vivo	NOUN
easat-2730	255	15	by	by	ADP
easat-2730	255	16	around	around	ADV
easat-2730	255	17	30	30	NUM
easat-2730	255	18	mm	mm	NOUN
easat-2730	255	19	hg	hg	NOUN
easat-2730	255	20	after	after	ADP
easat-2730	255	21	receiving	receive	VERB
easat-2730	255	22	short	short	ADJ
easat-2730	255	23	-	-	PUNCT
easat-2730	255	24	term	term	NOUN
easat-2730	255	25	doses	dose	NOUN
easat-2730	255	26	of	of	ADP
easat-2730	255	27	l	l	PROPN
easat-2730	255	28	-	-	PROPN
easat-2730	255	29	nmma	nmma	PROPN
easat-2730	255	30	or	or	CCONJ
easat-2730	255	31	l	l	NOUN
easat-2730	255	32	-	-	NOUN
easat-2730	255	33	na	na	NOUN
easat-2730	255	34	[	[	X
easat-2730	255	35	8	8	NUM
easat-2730	255	36	]	]	PUNCT
easat-2730	255	37	.	.	PUNCT
easat-2730	256	1	therefore	therefore	ADV
easat-2730	256	2	,	,	PUNCT
easat-2730	256	3	under	under	ADP
easat-2730	256	4	typical	typical	ADJ
easat-2730	256	5	circumstances	circumstance	NOUN
easat-2730	256	6	,	,	PUNCT
easat-2730	256	7	no	no	PRON
easat-2730	256	8	can	can	AUX
easat-2730	256	9	prevail	prevail	VERB
easat-2730	256	10	over	over	ADP
easat-2730	256	11	constrictive	constrictive	ADJ
easat-2730	256	12	forces	force	NOUN
easat-2730	256	13	.	.	PUNCT
easat-2730	257	1	in	in	ADP
easat-2730	257	2	another	another	DET
easat-2730	257	3	animal	animal	NOUN
easat-2730	257	4	model	model	NOUN
easat-2730	257	5	,	,	PUNCT
easat-2730	257	6	it	it	PRON
easat-2730	257	7	was	be	AUX
easat-2730	257	8	shown	show	VERB
easat-2730	257	9	that	that	SCONJ
easat-2730	257	10	lnmma	lnmma	PROPN
easat-2730	257	11	was	be	AUX
easat-2730	257	12	administered	administer	VERB
easat-2730	257	13	systemically	systemically	ADV
easat-2730	257	14	to	to	ADP
easat-2730	257	15	an	an	DET
easat-2730	257	16	awake	awake	ADJ
easat-2730	257	17	dog	dog	NOUN
easat-2730	257	18	at	at	ADP
easat-2730	257	19	dosages	dosage	NOUN
easat-2730	257	20	,	,	PUNCT
easat-2730	257	21	which	which	PRON
easat-2730	257	22	elevate	elevate	VERB
easat-2730	257	23	systemic	systemic	ADJ
easat-2730	257	24	blood	blood	NOUN
easat-2730	257	25	pressure	pressure	NOUN
easat-2730	257	26	by	by	ADP
easat-2730	257	27	inhibiting	inhibit	VERB
easat-2730	257	28	no	no	DET
easat-2730	257	29	secretion	secretion	NOUN
easat-2730	257	30	in	in	ADP
easat-2730	257	31	the	the	DET
easat-2730	257	32	systemic	systemic	ADJ
easat-2730	257	33	circulation	circulation	NOUN
easat-2730	257	34	and	and	CCONJ
easat-2730	257	35	by	by	ADP
easat-2730	257	36	increasing	increase	VERB
easat-2730	257	37	coronary	coronary	ADJ
easat-2730	257	38	vascular	vascular	ADJ
easat-2730	257	39	resistance	resistance	NOUN
easat-2730	257	40	.	.	PUNCT
easat-2730	258	1	this	this	DET
easat-2730	258	2	study	study	NOUN
easat-2730	258	3	raises	raise	VERB
easat-2730	258	4	the	the	DET
easat-2730	258	5	possibility	possibility	NOUN
easat-2730	258	6	that	that	SCONJ
easat-2730	258	7	no	no	DET
easat-2730	258	8	release	release	NOUN
easat-2730	258	9	,	,	PUNCT
easat-2730	258	10	particularly	particularly	ADV
easat-2730	258	11	at	at	ADP
easat-2730	258	12	the	the	DET
easat-2730	258	13	arterioles	arteriole	NOUN
easat-2730	258	14	(	(	PUNCT
easat-2730	258	15	resistance	resistance	NOUN
easat-2730	258	16	arteries	artery	NOUN
easat-2730	258	17	)	)	PUNCT
easat-2730	258	18	in	in	ADP
easat-2730	258	19	the	the	DET
easat-2730	258	20	vascular	vascular	ADJ
easat-2730	258	21	distributions	distribution	NOUN
easat-2730	258	22	,	,	PUNCT
easat-2730	258	23	may	may	AUX
easat-2730	258	24	be	be	AUX
easat-2730	258	25	physiologically	physiologically	ADV
easat-2730	258	26	important	important	ADJ
easat-2730	258	27	in	in	ADP
easat-2730	258	28	the	the	DET
easat-2730	258	29	modulation	modulation	NOUN
easat-2730	258	30	of	of	ADP
easat-2730	258	31	basal	basal	ADJ
easat-2730	258	32	systemic	systemic	ADJ
easat-2730	258	33	and	and	CCONJ
easat-2730	258	34	coronary	coronary	ADJ
easat-2730	258	35	tone	tone	NOUN
easat-2730	258	36	.	.	PUNCT
easat-2730	259	1	numerous	numerous	ADJ
easat-2730	259	2	studies	study	NOUN
easat-2730	259	3	have	have	AUX
easat-2730	259	4	examined	examine	VERB
easat-2730	259	5	the	the	DET
easat-2730	259	6	function	function	NOUN
easat-2730	259	7	of	of	ADP
easat-2730	259	8	no	no	PRON
easat-2730	259	9	in	in	ADP
easat-2730	259	10	human	human	ADJ
easat-2730	259	11	basal	basal	ADJ
easat-2730	259	12	vascular	vascular	NOUN
easat-2730	259	13	tone	tone	NOUN
easat-2730	259	14	[	[	X
easat-2730	259	15	40	40	NUM
easat-2730	259	16	]	]	PUNCT
easat-2730	259	17	.	.	PUNCT
easat-2730	260	1	when	when	SCONJ
easat-2730	260	2	lnmma	lnmma	PROPN
easat-2730	260	3	was	be	AUX
easat-2730	260	4	infused	infuse	VERB
easat-2730	260	5	intravenously	intravenously	ADV
easat-2730	260	6	,	,	PUNCT
easat-2730	260	7	no	no	DET
easat-2730	260	8	secretion	secretion	NOUN
easat-2730	260	9	in	in	ADP
easat-2730	260	10	the	the	DET
easat-2730	260	11	forearm	forearm	NOUN
easat-2730	260	12	was	be	AUX
easat-2730	260	13	inhibited	inhibit	VERB
easat-2730	260	14	,	,	PUNCT
easat-2730	260	15	and	and	CCONJ
easat-2730	260	16	the	the	DET
easat-2730	260	17	blood	blood	NOUN
easat-2730	260	18	flow	flow	NOUN
easat-2730	260	19	in	in	ADP
easat-2730	260	20	the	the	DET
easat-2730	260	21	arm	arm	NOUN
easat-2730	260	22	was	be	AUX
easat-2730	260	23	measured	measure	VERB
easat-2730	260	24	using	use	VERB
easat-2730	260	25	strain	strain	NOUN
easat-2730	260	26	gauge	gauge	NOUN
easat-2730	260	27	plethysmography	plethysmography	NOUN
easat-2730	260	28	before	before	ADP
easat-2730	260	29	and	and	CCONJ
easat-2730	260	30	after	after	ADP
easat-2730	260	31	this	this	DET
easat-2730	260	32	event	event	NOUN
easat-2730	260	33	.	.	PUNCT
easat-2730	261	1	because	because	SCONJ
easat-2730	261	2	of	of	ADP
easat-2730	261	3	the	the	DET
easat-2730	261	4	vasoconstrictor	vasoconstrictor	NOUN
easat-2730	261	5	effects	effect	NOUN
easat-2730	261	6	of	of	ADP
easat-2730	261	7	l	l	NOUN
easat-2730	261	8	-	-	NOUN
easat-2730	261	9	nmma	nmma	PROPN
easat-2730	261	10	,	,	PUNCT
easat-2730	261	11	it	it	PRON
easat-2730	261	12	is	be	AUX
easat-2730	261	13	possible	possible	ADJ
easat-2730	261	14	that	that	SCONJ
easat-2730	261	15	no	no	PRON
easat-2730	261	16	had	have	VERB
easat-2730	261	17	a	a	DET
easat-2730	261	18	substantial	substantial	ADJ
easat-2730	261	19	role	role	NOUN
easat-2730	261	20	in	in	ADP
easat-2730	261	21	the	the	DET
easat-2730	261	22	forearm	forearm	NOUN
easat-2730	261	23	's	's	PART
easat-2730	261	24	resistance	resistance	NOUN
easat-2730	261	25	to	to	ADP
easat-2730	261	26	the	the	DET
easat-2730	261	27	arterial	arterial	ADJ
easat-2730	261	28	basal	basal	ADJ
easat-2730	261	29	dilator	dilator	NOUN
easat-2730	261	30	tone	tone	NOUN
easat-2730	261	31	.	.	PUNCT
easat-2730	262	1	furthermore	furthermore	ADV
easat-2730	262	2	,	,	PUNCT
easat-2730	262	3	l	l	X
easat-2730	262	4	-	-	PROPN
easat-2730	262	5	nmma	nmma	PROPN
easat-2730	262	6	decreased	decrease	VERB
easat-2730	262	7	the	the	DET
easat-2730	262	8	vasodilatory	vasodilatory	ADJ
easat-2730	262	9	activity	activity	NOUN
easat-2730	262	10	to	to	ADP
easat-2730	262	11	intra	intra	ADJ
easat-2730	262	12	-	-	ADJ
easat-2730	262	13	arterial	arterial	ADJ
easat-2730	262	14	infusion	infusion	NOUN
easat-2730	262	15	of	of	ADP
easat-2730	262	16	acetylcholine	acetylcholine	NOUN
easat-2730	262	17	,	,	PUNCT
easat-2730	262	18	signifying	signify	VERB
easat-2730	262	19	that	that	SCONJ
easat-2730	262	20	this	this	DET
easat-2730	262	21	agonist	agonist	NOUN
easat-2730	262	22	enhances	enhance	VERB
easat-2730	262	23	no	no	DET
easat-2730	262	24	generation	generation	NOUN
easat-2730	262	25	from	from	ADP
easat-2730	262	26	endothelium	endothelium	NOUN
easat-2730	262	27	.	.	PUNCT
easat-2730	263	1	also	also	ADV
easat-2730	263	2	,	,	PUNCT
easat-2730	263	3	following	follow	VERB
easat-2730	263	4	the	the	DET
easat-2730	263	5	injection	injection	NOUN
easat-2730	263	6	of	of	ADP
easat-2730	263	7	l	l	NOUN
easat-2730	263	8	-	-	NOUN
easat-2730	263	9	nmma	nmma	PROPN
easat-2730	263	10	into	into	ADP
easat-2730	263	11	coronary	coronary	ADJ
easat-2730	263	12	arteries	artery	NOUN
easat-2730	263	13	of	of	ADP
easat-2730	263	14	indivivuals	indivivual	NOUN
easat-2730	263	15	with	with	ADP
easat-2730	263	16	normal	normal	ADJ
easat-2730	263	17	coronary	coronary	ADJ
easat-2730	263	18	angiograms	angiogram	NOUN
easat-2730	263	19	,	,	PUNCT
easat-2730	263	20	who	who	PRON
easat-2730	263	21	have	have	VERB
easat-2730	263	22	no	no	DET
easat-2730	263	23	associated	associated	ADJ
easat-2730	263	24	risk	risk	NOUN
easat-2730	263	25	to	to	PART
easat-2730	263	26	develop	develop	VERB
easat-2730	263	27	coronary	coronary	ADJ
easat-2730	263	28	atherosclerosis	atherosclerosis	NOUN
easat-2730	263	29	,	,	PUNCT
easat-2730	263	30	it	it	PRON
easat-2730	263	31	was	be	AUX
easat-2730	263	32	discovered	discover	VERB
easat-2730	263	33	that	that	SCONJ
easat-2730	263	34	the	the	DET
easat-2730	263	35	epicardial	epicardial	ADJ
easat-2730	263	36	coronary	coronary	ADJ
easat-2730	263	37	diameter	diameter	NOUN
easat-2730	263	38	and	and	CCONJ
easat-2730	263	39	coronary	coronary	ADJ
easat-2730	263	40	blood	blood	NOUN
easat-2730	263	41	flow	flow	NOUN
easat-2730	263	42	were	be	AUX
easat-2730	263	43	reduced	reduce	VERB
easat-2730	263	44	by	by	ADP
easat-2730	263	45	14	14	NUM
easat-2730	263	46	%	%	NOUN
easat-2730	263	47	and	and	CCONJ
easat-2730	263	48	19	19	NUM
easat-2730	263	49	%	%	NOUN
easat-2730	263	50	,	,	PUNCT
easat-2730	263	51	respectively	respectively	ADV
easat-2730	263	52	[	[	X
easat-2730	263	53	8	8	NUM
easat-2730	263	54	]	]	PUNCT
easat-2730	263	55	.	.	PUNCT
easat-2730	264	1	this	this	PRON
easat-2730	264	2	demonstrated	demonstrate	VERB
easat-2730	264	3	that	that	SCONJ
easat-2730	264	4	no	no	PRON
easat-2730	264	5	may	may	AUX
easat-2730	264	6	contribute	contribute	VERB
easat-2730	264	7	to	to	ADP
easat-2730	264	8	basal	basal	VERB
easat-2730	264	9	epicardial	epicardial	ADJ
easat-2730	264	10	and	and	CCONJ
easat-2730	264	11	arteriolar	arteriolar	ADJ
easat-2730	264	12	dilator	dilator	NOUN
easat-2730	264	13	tone	tone	NOUN
easat-2730	264	14	in	in	ADP
easat-2730	264	15	the	the	DET
easat-2730	264	16	normal	normal	ADJ
easat-2730	264	17	coronary	coronary	ADJ
easat-2730	264	18	circulation	circulation	NOUN
easat-2730	264	19	.	.	PUNCT
easat-2730	265	1	l	l	X
easat-2730	265	2	-	-	PROPN
easat-2730	265	3	nmma	nmma	PROPN
easat-2730	265	4	dramatically	dramatically	ADV
easat-2730	265	5	reduced	reduce	VERB
easat-2730	265	6	the	the	DET
easat-2730	265	7	acetylcholine	acetylcholine	NOUN
easat-2730	265	8	-	-	PUNCT
easat-2730	265	9	induced	induce	VERB
easat-2730	265	10	vasodilator	vasodilator	NOUN
easat-2730	265	11	response	response	NOUN
easat-2730	265	12	in	in	ADP
easat-2730	265	13	these	these	DET
easat-2730	265	14	healthy	healthy	ADJ
easat-2730	265	15	patients	patient	NOUN
easat-2730	265	16	at	at	ADP
easat-2730	265	17	the	the	DET
easat-2730	265	18	epicardial	epicardial	ADJ
easat-2730	265	19	and	and	CCONJ
easat-2730	265	20	microvascular	microvascular	ADJ
easat-2730	265	21	levels	level	NOUN
easat-2730	265	22	of	of	ADP
easat-2730	265	23	coronary	coronary	ADJ
easat-2730	265	24	circulation	circulation	NOUN
easat-2730	265	25	,	,	PUNCT
easat-2730	265	26	suggesting	suggest	VERB
easat-2730	265	27	that	that	SCONJ
easat-2730	265	28	acetylcholine	acetylcholine	NOUN
easat-2730	265	29	may	may	AUX
easat-2730	265	30	facilitate	facilitate	VERB
easat-2730	265	31	the	the	DET
easat-2730	265	32	secretion	secretion	NOUN
easat-2730	265	33	of	of	ADP
easat-2730	265	34	no	no	PRON
easat-2730	265	35	from	from	ADP
easat-2730	265	36	the	the	DET
easat-2730	265	37	coronary	coronary	ADJ
easat-2730	265	38	endothelium	endothelium	NOUN
easat-2730	265	39	[	[	X
easat-2730	265	40	1	1	NUM
easat-2730	265	41	,	,	PUNCT
easat-2730	265	42	6	6	NUM
easat-2730	265	43	]	]	PUNCT
easat-2730	265	44	.	.	PUNCT
easat-2730	266	1	3.2.4	3.2.4	NUM
easat-2730	266	2	.	.	PUNCT
easat-2730	267	1	the	the	DET
easat-2730	267	2	key	key	ADJ
easat-2730	267	3	modulators	modulator	NOUN
easat-2730	267	4	of	of	ADP
easat-2730	267	5	no	no	DET
easat-2730	267	6	pathways	pathway	NOUN
easat-2730	267	7	currently	currently	ADV
easat-2730	267	8	,	,	PUNCT
easat-2730	267	9	the	the	DET
easat-2730	267	10	used	use	VERB
easat-2730	267	11	of	of	ADP
easat-2730	267	12	no	no	PRON
easat-2730	267	13	to	to	PART
easat-2730	267	14	restore	restore	VERB
easat-2730	267	15	homeostasis	homeostasis	NOUN
easat-2730	267	16	has	have	AUX
easat-2730	267	17	been	be	AUX
easat-2730	267	18	improved	improve	VERB
easat-2730	267	19	by	by	ADP
easat-2730	267	20	many	many	ADJ
easat-2730	267	21	treatment	treatment	NOUN
easat-2730	267	22	approaches	approach	NOUN
easat-2730	267	23	.	.	PUNCT
easat-2730	268	1	the	the	DET
easat-2730	268	2	most	most	ADV
easat-2730	268	3	effective	effective	ADJ
easat-2730	268	4	approach	approach	NOUN
easat-2730	268	5	at	at	ADP
easat-2730	268	6	this	this	DET
easat-2730	268	7	time	time	NOUN
easat-2730	268	8	is	be	AUX
easat-2730	268	9	requires	require	VERB
easat-2730	268	10	the	the	DET
easat-2730	268	11	administration	administration	NOUN
easat-2730	268	12	of	of	ADP
easat-2730	268	13	some	some	DET
easat-2730	268	14	drugs	drug	NOUN
easat-2730	268	15	to	to	PART
easat-2730	268	16	trigger	trigger	VERB
easat-2730	268	17	the	the	DET
easat-2730	268	18	downstream	downstream	NOUN
easat-2730	268	19	enos	eno	NOUN
easat-2730	268	20	/	/	SYM
easat-2730	268	21	no	no	DET
easat-2730	268	22	effectors	effector	NOUN
easat-2730	268	23	and	and	CCONJ
easat-2730	268	24	inhibit	inhibit	VERB
easat-2730	268	25	enos	eno	NOUN
easat-2730	268	26	uncoupling	uncouple	VERB
easat-2730	268	27	,	,	PUNCT
easat-2730	268	28	improve	improve	VERB
easat-2730	268	29	bh4	bh4	NOUN
easat-2730	268	30	and	and	CCONJ
easat-2730	268	31	l	l	NOUN
easat-2730	268	32	-	-	NOUN
easat-2730	268	33	arginine	arginine	NOUN
easat-2730	268	34	bioavailability	bioavailability	NOUN
easat-2730	268	35	,	,	PUNCT
easat-2730	268	36	and	and	CCONJ
easat-2730	268	37	control	control	NOUN
easat-2730	268	38	enos	enos	PROPN
easat-2730	268	39	post	post	ADJ
easat-2730	268	40	-	-	ADJ
easat-2730	268	41	translational	translational	ADJ
easat-2730	268	42	modifications	modification	NOUN
easat-2730	269	1	[	[	X
easat-2730	269	2	43	43	NUM
easat-2730	269	3	]	]	PUNCT
easat-2730	269	4	.	.	PUNCT
easat-2730	270	1	there	there	PRON
easat-2730	270	2	are	be	VERB
easat-2730	270	3	numerous	numerous	ADJ
easat-2730	270	4	therapeutic	therapeutic	ADJ
easat-2730	270	5	strategies	strategy	NOUN
easat-2730	270	6	available	available	ADJ
easat-2730	270	7	,	,	PUNCT
easat-2730	270	8	which	which	PRON
easat-2730	270	9	target	target	VERB
easat-2730	270	10	the	the	DET
easat-2730	270	11	production	production	NOUN
easat-2730	270	12	and	and	CCONJ
easat-2730	270	13	oxidative	oxidative	ADJ
easat-2730	270	14	inhibition	inhibition	NOUN
easat-2730	270	15	of	of	ADP
easat-2730	270	16	no	no	PRON
easat-2730	270	17	in	in	ADP
easat-2730	270	18	the	the	DET
easat-2730	270	19	human	human	ADJ
easat-2730	270	20	vascular	vascular	NOUN
easat-2730	270	21	.	.	PUNCT
easat-2730	271	1	it	it	PRON
easat-2730	271	2	is	be	AUX
easat-2730	271	3	commonly	commonly	ADV
easat-2730	271	4	acknowledged	acknowledge	VERB
easat-2730	271	5	that	that	SCONJ
easat-2730	271	6	inhibiting	inhibit	VERB
easat-2730	271	7	the	the	DET
easat-2730	271	8	renin	renin	ADJ
easat-2730	271	9	-	-	PUNCT
easat-2730	271	10	angiotensin	angiotensin	NOUN
easat-2730	271	11	-	-	PUNCT
easat-2730	271	12	aldosterone	aldosterone	NOUN
easat-2730	271	13	pathway	pathway	NOUN
easat-2730	271	14	is	be	AUX
easat-2730	271	15	an	an	DET
easat-2730	271	16	effective	effective	ADJ
easat-2730	271	17	treatment	treatment	NOUN
easat-2730	271	18	for	for	ADP
easat-2730	271	19	obesity	obesity	NOUN
easat-2730	271	20	-	-	PUNCT
easat-2730	271	21	induced	induce	VERB
easat-2730	271	22	endothelial	endothelial	ADJ
easat-2730	271	23	dysfunction	dysfunction	NOUN
easat-2730	271	24	related	relate	VERB
easat-2730	271	25	to	to	ADP
easat-2730	271	26	cvds	cvds	PROPN
easat-2730	271	27	[	[	X
easat-2730	271	28	44	44	NUM
easat-2730	271	29	]	]	PUNCT
easat-2730	271	30	.	.	PUNCT
easat-2730	272	1	3452	3452	NUM
easat-2730	272	2	edelweiss	edelweiss	PROPN
easat-2730	272	3	applied	apply	VERB
easat-2730	272	4	science	science	NOUN
easat-2730	272	5	and	and	CCONJ
easat-2730	272	6	technology	technology	NOUN
easat-2730	272	7	issn	issn	PROPN
easat-2730	272	8	:	:	PUNCT
easat-2730	272	9	2576	2576	NUM
easat-2730	272	10	-	-	SYM
easat-2730	272	11	8484	8484	NUM
easat-2730	272	12	vol	vol	NOUN
easat-2730	272	13	.	.	PROPN
easat-2730	272	14	8	8	NUM
easat-2730	272	15	,	,	PUNCT
easat-2730	272	16	no	no	INTJ
easat-2730	272	17	.	.	NOUN
easat-2730	273	1	6	6	NUM
easat-2730	273	2	:	:	SYM
easat-2730	273	3	3441	3441	NUM
easat-2730	273	4	-	-	SYM
easat-2730	273	5	3456	3456	NUM
easat-2730	273	6	,	,	PUNCT
easat-2730	273	7	2024	2024	NUM
easat-2730	273	8	doi	doi	NOUN
easat-2730	273	9	:	:	PUNCT
easat-2730	273	10	10.55214/25768484.v8i6.2730	10.55214/25768484.v8i6.2730	NUM
easat-2730	273	11	©	©	ADP
easat-2730	273	12	2024	2024	NUM
easat-2730	273	13	by	by	ADP
easat-2730	273	14	the	the	DET
easat-2730	273	15	authors	author	NOUN
easat-2730	273	16	;	;	PUNCT
easat-2730	273	17	licensee	licensee	PROPN
easat-2730	273	18	learning	learn	VERB
easat-2730	273	19	gate	gate	NOUN
easat-2730	273	20	angiotensin	angiotensin	NOUN
easat-2730	273	21	-	-	PUNCT
easat-2730	273	22	converting	convert	VERB
easat-2730	273	23	enzyme	enzyme	NOUN
easat-2730	273	24	inhibitors	inhibitor	NOUN
easat-2730	273	25	(	(	PUNCT
easat-2730	273	26	ace	ace	NOUN
easat-2730	273	27	-	-	PUNCT
easat-2730	273	28	i	i	NOUN
easat-2730	273	29	)	)	PUNCT
easat-2730	273	30	and	and	CCONJ
easat-2730	273	31	at1	at1	PROPN
easat-2730	273	32	receptor	receptor	NOUN
easat-2730	273	33	blockers	blocker	NOUN
easat-2730	273	34	(	(	PUNCT
easat-2730	273	35	arbs	arb	NOUN
easat-2730	273	36	)	)	PUNCT
easat-2730	273	37	can	can	AUX
easat-2730	273	38	increase	increase	VERB
easat-2730	273	39	bh4	bh4	NOUN
easat-2730	273	40	bioavailability	bioavailability	NOUN
easat-2730	273	41	,	,	PUNCT
easat-2730	273	42	decrease	decrease	NOUN
easat-2730	273	43	enos	eno	NOUN
easat-2730	273	44	uncoupling	uncouple	VERB
easat-2730	273	45	,	,	PUNCT
easat-2730	273	46	and	and	CCONJ
easat-2730	273	47	prevent	prevent	VERB
easat-2730	273	48	cerebral	cerebral	ADJ
easat-2730	273	49	ischemia	ischemia	NOUN
easat-2730	273	50	by	by	ADP
easat-2730	273	51	increasing	increase	VERB
easat-2730	273	52	enos	eno	NOUN
easat-2730	273	53	activity	activity	NOUN
easat-2730	273	54	in	in	ADP
easat-2730	273	55	the	the	DET
easat-2730	273	56	middle	middle	ADJ
easat-2730	273	57	cerebral	cerebral	ADJ
easat-2730	273	58	artery	artery	NOUN
easat-2730	273	59	,	,	PUNCT
easat-2730	273	60	while	while	SCONJ
easat-2730	273	61	decreasing	decrease	VERB
easat-2730	273	62	the	the	DET
easat-2730	273	63	size	size	NOUN
easat-2730	273	64	of	of	ADP
easat-2730	273	65	cerebral	cerebral	ADJ
easat-2730	273	66	infarcts	infarct	NOUN
easat-2730	273	67	as	as	SCONJ
easat-2730	273	68	investigated	investigate	VERB
easat-2730	273	69	in	in	ADP
easat-2730	273	70	animal	animal	NOUN
easat-2730	273	71	models	model	NOUN
easat-2730	273	72	[	[	X
easat-2730	273	73	9	9	NUM
easat-2730	273	74	]	]	PUNCT
easat-2730	273	75	.	.	PUNCT
easat-2730	274	1	the	the	DET
easat-2730	274	2	renin	renin	ADJ
easat-2730	274	3	-	-	PUNCT
easat-2730	274	4	angiotensin	angiotensin	NOUN
easat-2730	274	5	system	system	NOUN
easat-2730	274	6	blockers	blocker	NOUN
easat-2730	274	7	also	also	ADV
easat-2730	274	8	have	have	VERB
easat-2730	274	9	no	no	PRON
easat-2730	274	10	-	-	PUNCT
easat-2730	274	11	dependent	dependent	ADJ
easat-2730	274	12	antithrombotic	antithrombotic	ADJ
easat-2730	274	13	actions	action	NOUN
easat-2730	274	14	.	.	PUNCT
easat-2730	275	1	in	in	ADP
easat-2730	275	2	addition	addition	NOUN
easat-2730	275	3	to	to	ADP
easat-2730	275	4	this	this	PRON
easat-2730	275	5	,	,	PUNCT
easat-2730	275	6	a	a	DET
easat-2730	275	7	study	study	NOUN
easat-2730	275	8	has	have	AUX
easat-2730	275	9	shown	show	VERB
easat-2730	275	10	that	that	SCONJ
easat-2730	275	11	angiotensin	angiotensin	NOUN
easat-2730	275	12	1	1	NUM
easat-2730	275	13	-	-	SYM
easat-2730	275	14	7	7	NUM
easat-2730	275	15	,	,	PUNCT
easat-2730	275	16	a	a	DET
easat-2730	275	17	part	part	NOUN
easat-2730	275	18	of	of	ADP
easat-2730	275	19	the	the	DET
easat-2730	275	20	renin	renin	ADJ
easat-2730	275	21	-	-	PUNCT
easat-2730	275	22	angiotensin	angiotensin	NOUN
easat-2730	275	23	system	system	NOUN
easat-2730	275	24	,	,	PUNCT
easat-2730	275	25	enhanced	enhance	VERB
easat-2730	275	26	the	the	DET
easat-2730	275	27	generation	generation	NOUN
easat-2730	275	28	of	of	ADP
easat-2730	275	29	no	no	NOUN
easat-2730	275	30	,	,	PUNCT
easat-2730	275	31	which	which	PRON
easat-2730	275	32	helps	help	VERB
easat-2730	275	33	to	to	PART
easat-2730	275	34	reduce	reduce	VERB
easat-2730	275	35	thrombosis	thrombosis	NOUN
easat-2730	275	36	in	in	ADP
easat-2730	275	37	rats	rat	NOUN
easat-2730	275	38	.	.	PUNCT
easat-2730	276	1	additionally	additionally	ADV
easat-2730	276	2	,	,	PUNCT
easat-2730	276	3	the	the	DET
easat-2730	276	4	antioxidant	antioxidant	NOUN
easat-2730	276	5	,	,	PUNCT
easat-2730	276	6	anti	anti	ADJ
easat-2730	276	7	-	-	ADJ
easat-2730	276	8	inflammatory	inflammatory	ADJ
easat-2730	276	9	,	,	PUNCT
easat-2730	276	10	and	and	CCONJ
easat-2730	276	11	anti	anti	ADJ
easat-2730	276	12	-	-	ADJ
easat-2730	276	13	atherosclerotic	atherosclerotic	ADJ
easat-2730	276	14	potentials	potential	NOUN
easat-2730	276	15	of	of	ADP
easat-2730	276	16	statins	statin	NOUN
easat-2730	276	17	,	,	PUNCT
easat-2730	276	18	help	help	VERB
easat-2730	276	19	to	to	PART
easat-2730	276	20	lower	lower	VERB
easat-2730	276	21	cholesterol	cholesterol	NOUN
easat-2730	276	22	and	and	CCONJ
easat-2730	276	23	promote	promote	VERB
easat-2730	276	24	endothelial	endothelial	ADJ
easat-2730	276	25	functions	function	NOUN
easat-2730	276	26	by	by	ADP
easat-2730	276	27	increasing	increase	VERB
easat-2730	276	28	no	no	DET
easat-2730	276	29	bioavailability	bioavailability	NOUN
easat-2730	276	30	.	.	PUNCT
easat-2730	277	1	previous	previous	ADJ
easat-2730	277	2	study	study	NOUN
easat-2730	277	3	has	have	AUX
easat-2730	277	4	reported	report	VERB
easat-2730	277	5	that	that	SCONJ
easat-2730	277	6	fluvastatin	fluvastatin	NOUN
easat-2730	277	7	treatment	treatment	NOUN
easat-2730	277	8	improved	improve	VERB
easat-2730	277	9	endothelial	endothelial	ADJ
easat-2730	277	10	vasodilation	vasodilation	NOUN
easat-2730	277	11	by	by	ADP
easat-2730	277	12	increasing	increase	VERB
easat-2730	277	13	no	no	DET
easat-2730	277	14	production	production	NOUN
easat-2730	277	15	in	in	ADP
easat-2730	277	16	hypercholesterolemic	hypercholesterolemic	ADJ
easat-2730	277	17	individuals	individual	NOUN
easat-2730	277	18	[	[	X
easat-2730	277	19	9	9	NUM
easat-2730	277	20	]	]	PUNCT
easat-2730	277	21	.	.	PUNCT
easat-2730	278	1	in	in	ADP
easat-2730	278	2	an	an	DET
easat-2730	278	3	experimental	experimental	ADJ
easat-2730	278	4	mi	mi	PROPN
easat-2730	278	5	rat	rat	PROPN
easat-2730	278	6	model	model	PROPN
easat-2730	278	7	,	,	PUNCT
easat-2730	278	8	statins	statin	NOUN
easat-2730	278	9	have	have	AUX
easat-2730	278	10	been	be	AUX
easat-2730	278	11	found	find	VERB
easat-2730	278	12	to	to	PART
easat-2730	278	13	decrease	decrease	VERB
easat-2730	278	14	enos	eno	NOUN
easat-2730	278	15	uncoupling	uncouple	VERB
easat-2730	278	16	by	by	ADP
easat-2730	278	17	decreasing	decrease	VERB
easat-2730	278	18	vascular	vascular	ADJ
easat-2730	278	19	o2	o2	NOUN
easat-2730	278	20	and	and	CCONJ
easat-2730	278	21	bh4	bh4	NOUN
easat-2730	278	22	oxidation	oxidation	NOUN
easat-2730	278	23	.	.	PUNCT
easat-2730	279	1	also	also	ADV
easat-2730	279	2	,	,	PUNCT
easat-2730	279	3	statins	statins	PROPN
easat-2730	279	4	were	be	AUX
easat-2730	279	5	discovered	discover	VERB
easat-2730	279	6	to	to	PART
easat-2730	279	7	prolong	prolong	VERB
easat-2730	279	8	longevity	longevity	NOUN
easat-2730	279	9	by	by	ADP
easat-2730	279	10	restoring	restore	VERB
easat-2730	279	11	epcs	epc	NOUN
easat-2730	279	12	mobility	mobility	NOUN
easat-2730	279	13	,	,	PUNCT
easat-2730	279	14	neovascularization	neovascularization	NOUN
easat-2730	279	15	of	of	ADP
easat-2730	279	16	the	the	DET
easat-2730	279	17	heart	heart	NOUN
easat-2730	279	18	,	,	PUNCT
easat-2730	279	19	and	and	CCONJ
easat-2730	279	20	enhancing	enhance	VERB
easat-2730	279	21	no	no	DET
easat-2730	279	22	bioavailability	bioavailability	NOUN
easat-2730	279	23	.	.	PUNCT
easat-2730	280	1	improved	improve	VERB
easat-2730	280	2	endothelium	endothelium	NOUN
easat-2730	280	3	homeostasis	homeostasis	NOUN
easat-2730	280	4	can	can	AUX
easat-2730	280	5	also	also	ADV
easat-2730	280	6	be	be	AUX
easat-2730	280	7	achieved	achieve	VERB
easat-2730	280	8	by	by	ADP
easat-2730	280	9	stimulating	stimulate	VERB
easat-2730	280	10	β	β	NUM
easat-2730	280	11	--	--	PUNCT
easat-2730	280	12	adrenoreceptor	adrenoreceptor	NOUN
easat-2730	280	13	subtype	subtype	NOUN
easat-2730	280	14	3	3	NUM
easat-2730	280	15	(	(	PUNCT
easat-2730	280	16	β3	β3	PROPN
easat-2730	280	17	)	)	PUNCT
easat-2730	280	18	,	,	PUNCT
easat-2730	280	19	that	that	PRON
easat-2730	280	20	causes	cause	VERB
easat-2730	280	21	enos	eno	NOUN
easat-2730	280	22	activation	activation	NOUN
easat-2730	280	23	and	and	CCONJ
easat-2730	280	24	ultimately	ultimately	ADV
easat-2730	280	25	increases	increase	VERB
easat-2730	280	26	no	no	DET
easat-2730	280	27	bioavailability	bioavailability	NOUN
easat-2730	280	28	[	[	X
easat-2730	280	29	45	45	NUM
easat-2730	280	30	]	]	PUNCT
easat-2730	280	31	.	.	PUNCT
easat-2730	281	1	a	a	DET
easat-2730	281	2	prospective	prospective	ADJ
easat-2730	281	3	medication	medication	NOUN
easat-2730	281	4	that	that	PRON
easat-2730	281	5	can	can	AUX
easat-2730	281	6	improve	improve	VERB
easat-2730	281	7	no	no	DET
easat-2730	281	8	pathways	pathway	NOUN
easat-2730	281	9	is	be	AUX
easat-2730	281	10	nebivolol	nebivolol	ADJ
easat-2730	281	11	,	,	PUNCT
easat-2730	281	12	a	a	DET
easat-2730	281	13	thirdgeneration	thirdgeneration	NOUN
easat-2730	281	14	β	β	NOUN
easat-2730	281	15	--	--	PUNCT
easat-2730	281	16	adrenoreceptor	adrenoreceptor	NOUN
easat-2730	281	17	blocker	blocker	NOUN
easat-2730	281	18	,	,	PUNCT
easat-2730	281	19	since	since	SCONJ
easat-2730	281	20	it	it	PRON
easat-2730	281	21	can	can	AUX
easat-2730	281	22	inhibit	inhibit	VERB
easat-2730	281	23	β-1	β-1	PRON
easat-2730	281	24	and	and	CCONJ
easat-2730	281	25	activate	activate	VERB
easat-2730	281	26	β-3	β-3	NOUN
easat-2730	281	27	receptors	receptor	NOUN
easat-2730	281	28	.	.	PUNCT
easat-2730	282	1	existing	exist	VERB
easat-2730	282	2	studies	study	NOUN
easat-2730	282	3	have	have	AUX
easat-2730	282	4	reported	report	VERB
easat-2730	282	5	that	that	SCONJ
easat-2730	282	6	nebivolol	nebivolol	ADJ
easat-2730	282	7	increases	increase	VERB
easat-2730	282	8	the	the	DET
easat-2730	282	9	production	production	NOUN
easat-2730	282	10	of	of	ADP
easat-2730	282	11	endothelial	endothelial	NOUN
easat-2730	282	12	no	no	ADV
easat-2730	282	13	in	in	ADP
easat-2730	282	14	the	the	DET
easat-2730	282	15	conductance	conductance	NOUN
easat-2730	282	16	and	and	CCONJ
easat-2730	282	17	resistance	resistance	NOUN
easat-2730	282	18	of	of	ADP
easat-2730	282	19	rat	rat	NOUN
easat-2730	282	20	arteries	artery	NOUN
easat-2730	282	21	in	in	ADP
easat-2730	282	22	a	a	DET
easat-2730	282	23	calcium	calcium	NOUN
easat-2730	282	24	-	-	PUNCT
easat-2730	282	25	dependent	dependent	ADJ
easat-2730	282	26	way	way	NOUN
easat-2730	282	27	.	.	PUNCT
easat-2730	283	1	the	the	DET
easat-2730	283	2	same	same	ADJ
easat-2730	283	3	researchers	researcher	NOUN
easat-2730	283	4	examined	examine	VERB
easat-2730	283	5	the	the	DET
easat-2730	283	6	heart	heart	NOUN
easat-2730	283	7	production	production	NOUN
easat-2730	283	8	of	of	ADP
easat-2730	283	9	the	the	DET
easat-2730	283	10	no	no	NOUN
easat-2730	283	11	in	in	ADP
easat-2730	283	12	mice	mouse	NOUN
easat-2730	283	13	after	after	SCONJ
easat-2730	283	14	inos	ino	NOUN
easat-2730	283	15	enhanced	enhance	VERB
easat-2730	283	16	activity	activity	NOUN
easat-2730	283	17	and	and	CCONJ
easat-2730	283	18	activation	activation	NOUN
easat-2730	283	19	of	of	ADP
easat-2730	283	20	the	the	DET
easat-2730	283	21	β3	β3	ADJ
easat-2730	283	22	receptor	receptor	NOUN
easat-2730	283	23	.	.	PUNCT
easat-2730	284	1	hence	hence	ADV
easat-2730	284	2	,	,	PUNCT
easat-2730	284	3	nebivolol	nebivolol	PROPN
easat-2730	284	4	can	can	AUX
easat-2730	284	5	be	be	AUX
easat-2730	284	6	considered	consider	VERB
easat-2730	284	7	as	as	ADP
easat-2730	284	8	a	a	DET
easat-2730	284	9	therapeutic	therapeutic	ADJ
easat-2730	284	10	target	target	NOUN
easat-2730	284	11	for	for	ADP
easat-2730	284	12	cvds	cvds	PROPN
easat-2730	284	13	associated	associate	VERB
easat-2730	284	14	with	with	ADP
easat-2730	284	15	obesity	obesity	NOUN
easat-2730	284	16	-	-	PUNCT
easat-2730	284	17	induced	induce	VERB
easat-2730	284	18	endothelial	endothelial	ADJ
easat-2730	284	19	dysfunction	dysfunction	NOUN
easat-2730	284	20	.	.	PUNCT
easat-2730	285	1	the	the	DET
easat-2730	285	2	relationship	relationship	NOUN
easat-2730	285	3	between	between	ADP
easat-2730	285	4	the	the	DET
easat-2730	285	5	adrenergic	adrenergic	ADJ
easat-2730	285	6	pathway	pathway	NOUN
easat-2730	285	7	,	,	PUNCT
easat-2730	285	8	no	no	DET
easat-2730	285	9	bioavailability	bioavailability	NOUN
easat-2730	285	10	,	,	PUNCT
easat-2730	285	11	and	and	CCONJ
easat-2730	285	12	oxidative	oxidative	ADJ
easat-2730	285	13	stress	stress	NOUN
easat-2730	285	14	is	be	AUX
easat-2730	285	15	another	another	DET
easat-2730	285	16	aspect	aspect	NOUN
easat-2730	285	17	that	that	PRON
easat-2730	285	18	requires	require	VERB
easat-2730	285	19	attention	attention	NOUN
easat-2730	285	20	.	.	PUNCT
easat-2730	286	1	this	this	DET
easat-2730	286	2	context	context	NOUN
easat-2730	286	3	shows	show	VERB
easat-2730	286	4	that	that	SCONJ
easat-2730	286	5	the	the	DET
easat-2730	286	6	significant	significant	ADJ
easat-2730	286	7	effects	effect	NOUN
easat-2730	286	8	of	of	ADP
easat-2730	286	9	nebivolol	nebivolol	NOUN
easat-2730	286	10	are	be	AUX
easat-2730	286	11	due	due	ADJ
easat-2730	286	12	to	to	ADP
easat-2730	286	13	its	its	PRON
easat-2730	286	14	antioxidant	antioxidant	ADJ
easat-2730	286	15	potentials	potential	NOUN
easat-2730	286	16	,	,	PUNCT
easat-2730	286	17	that	that	PRON
easat-2730	286	18	were	be	AUX
easat-2730	286	19	thought	think	VERB
easat-2730	286	20	to	to	PART
easat-2730	286	21	be	be	AUX
easat-2730	286	22	another	another	DET
easat-2730	286	23	factor	factor	NOUN
easat-2730	286	24	that	that	PRON
easat-2730	286	25	causes	cause	VERB
easat-2730	286	26	an	an	DET
easat-2730	286	27	increase	increase	NOUN
easat-2730	286	28	in	in	ADP
easat-2730	286	29	the	the	DET
easat-2730	286	30	no	no	DET
easat-2730	286	31	bioavailability	bioavailability	NOUN
easat-2730	286	32	[	[	X
easat-2730	286	33	46	46	NUM
easat-2730	286	34	]	]	PUNCT
easat-2730	286	35	.	.	PUNCT
easat-2730	287	1	nebivolol	nebivolol	PROPN
easat-2730	287	2	has	have	AUX
easat-2730	287	3	also	also	ADV
easat-2730	287	4	been	be	AUX
easat-2730	287	5	proven	prove	VERB
easat-2730	287	6	to	to	PART
easat-2730	287	7	improve	improve	VERB
easat-2730	287	8	mortality	mortality	NOUN
easat-2730	287	9	and	and	CCONJ
easat-2730	287	10	morbidity	morbidity	NOUN
easat-2730	287	11	in	in	ADP
easat-2730	287	12	elderly	elderly	ADJ
easat-2730	287	13	individuals	individual	NOUN
easat-2730	287	14	with	with	ADP
easat-2730	287	15	cvds	cvds	PROPN
easat-2730	287	16	.	.	PUNCT
easat-2730	288	1	it	it	PRON
easat-2730	288	2	has	have	AUX
easat-2730	288	3	been	be	AUX
easat-2730	288	4	shown	show	VERB
easat-2730	288	5	to	to	PART
easat-2730	288	6	inhibit	inhibit	VERB
easat-2730	288	7	platelet	platelet	NOUN
easat-2730	288	8	aggregation	aggregation	NOUN
easat-2730	288	9	by	by	ADP
easat-2730	288	10	increasing	increase	VERB
easat-2730	288	11	no	no	DET
easat-2730	288	12	bioavailability	bioavailability	NOUN
easat-2730	288	13	,	,	PUNCT
easat-2730	288	14	which	which	PRON
easat-2730	288	15	indicates	indicate	VERB
easat-2730	288	16	the	the	DET
easat-2730	288	17	antithrombotic	antithrombotic	ADJ
easat-2730	288	18	effects	effect	NOUN
easat-2730	288	19	of	of	ADP
easat-2730	288	20	this	this	DET
easat-2730	288	21	β	β	NOUN
easat-2730	288	22	-	-	NOUN
easat-2730	288	23	blocker	blocker	NOUN
easat-2730	288	24	[	[	X
easat-2730	288	25	47	47	NUM
easat-2730	288	26	]	]	PUNCT
easat-2730	288	27	.	.	PUNCT
easat-2730	289	1	however	however	ADV
easat-2730	289	2	,	,	PUNCT
easat-2730	289	3	it	it	PRON
easat-2730	289	4	is	be	AUX
easat-2730	289	5	very	very	ADV
easat-2730	289	6	essential	essential	ADJ
easat-2730	289	7	to	to	PART
easat-2730	289	8	know	know	VERB
easat-2730	289	9	that	that	SCONJ
easat-2730	289	10	adopting	adopt	VERB
easat-2730	289	11	a	a	DET
easat-2730	289	12	normal	normal	ADJ
easat-2730	289	13	lifestyle	lifestyle	NOUN
easat-2730	289	14	is	be	AUX
easat-2730	289	15	a	a	DET
easat-2730	289	16	useful	useful	ADJ
easat-2730	289	17	strategy	strategy	NOUN
easat-2730	289	18	for	for	ADP
easat-2730	289	19	the	the	DET
easat-2730	289	20	prevention	prevention	NOUN
easat-2730	289	21	and	and	CCONJ
easat-2730	289	22	attenuation	attenuation	NOUN
easat-2730	289	23	of	of	ADP
easat-2730	289	24	obesity	obesity	NOUN
easat-2730	289	25	-	-	PUNCT
easat-2730	289	26	induced	induce	VERB
easat-2730	289	27	endothelial	endothelial	ADJ
easat-2730	289	28	dysfunction	dysfunction	NOUN
easat-2730	289	29	linked	link	VERB
easat-2730	289	30	with	with	ADP
easat-2730	289	31	cvds	cvds	PROPN
easat-2730	289	32	.	.	PUNCT
easat-2730	290	1	in	in	ADP
easat-2730	290	2	this	this	DET
easat-2730	290	3	regard	regard	NOUN
easat-2730	290	4	,	,	PUNCT
easat-2730	290	5	physical	physical	ADJ
easat-2730	290	6	activity	activity	NOUN
easat-2730	290	7	and	and	CCONJ
easat-2730	290	8	certain	certain	ADJ
easat-2730	290	9	diets	diet	NOUN
easat-2730	290	10	,	,	PUNCT
easat-2730	290	11	including	include	VERB
easat-2730	290	12	diets	diet	NOUN
easat-2730	290	13	rich	rich	ADJ
easat-2730	290	14	in	in	ADP
easat-2730	290	15	polyphenols	polyphenol	NOUN
easat-2730	290	16	,	,	PUNCT
easat-2730	290	17	were	be	AUX
easat-2730	290	18	identified	identify	VERB
easat-2730	290	19	to	to	PART
easat-2730	290	20	activate	activate	VERB
easat-2730	290	21	no	no	DET
easat-2730	290	22	pathways	pathway	NOUN
easat-2730	290	23	.	.	PUNCT
easat-2730	291	1	physical	physical	ADJ
easat-2730	291	2	activity	activity	NOUN
easat-2730	291	3	(	(	PUNCT
easat-2730	291	4	pe	pe	INTJ
easat-2730	291	5	)	)	PUNCT
easat-2730	291	6	is	be	AUX
easat-2730	291	7	crucial	crucial	ADJ
easat-2730	291	8	for	for	ADP
easat-2730	291	9	lowering	lower	VERB
easat-2730	291	10	the	the	DET
easat-2730	291	11	risk	risk	NOUN
easat-2730	291	12	of	of	ADP
easat-2730	291	13	cvds	cvds	PROPN
easat-2730	291	14	,	,	PUNCT
easat-2730	291	15	oxidative	oxidative	ADJ
easat-2730	291	16	stress	stress	NOUN
easat-2730	291	17	linked	link	VERB
easat-2730	291	18	to	to	ADP
easat-2730	291	19	ageing	age	VERB
easat-2730	291	20	,	,	PUNCT
easat-2730	291	21	preventing	prevent	VERB
easat-2730	291	22	and	and	CCONJ
easat-2730	291	23	attenuating	attenuate	VERB
easat-2730	291	24	endothelial	endothelial	ADJ
easat-2730	291	25	dysfunction	dysfunction	NOUN
easat-2730	291	26	,	,	PUNCT
easat-2730	291	27	as	as	SCONJ
easat-2730	291	28	shown	show	VERB
easat-2730	291	29	by	by	ADP
easat-2730	291	30	several	several	ADJ
easat-2730	291	31	experimental	experimental	ADJ
easat-2730	291	32	and	and	CCONJ
easat-2730	291	33	epidemiological	epidemiological	ADJ
easat-2730	291	34	findings	finding	NOUN
easat-2730	291	35	[	[	X
easat-2730	291	36	48	48	NUM
easat-2730	291	37	]	]	PUNCT
easat-2730	291	38	.	.	PUNCT
easat-2730	292	1	recent	recent	ADJ
easat-2730	292	2	research	research	NOUN
easat-2730	292	3	has	have	AUX
easat-2730	292	4	demonstrated	demonstrate	VERB
easat-2730	292	5	that	that	SCONJ
easat-2730	292	6	regular	regular	ADJ
easat-2730	292	7	exercise	exercise	NOUN
easat-2730	292	8	reduces	reduce	VERB
easat-2730	292	9	oxidative	oxidative	ADJ
easat-2730	292	10	stress	stress	NOUN
easat-2730	292	11	and	and	CCONJ
easat-2730	292	12	activates	activate	VERB
easat-2730	292	13	the	the	DET
easat-2730	292	14	production	production	NOUN
easat-2730	292	15	of	of	ADP
easat-2730	292	16	nitrite	nitrite	NOUN
easat-2730	292	17	and	and	CCONJ
easat-2730	292	18	enos	eno	VERB
easat-2730	292	19	in	in	ADP
easat-2730	292	20	spontaneously	spontaneously	ADV
easat-2730	292	21	hypertensive	hypertensive	ADJ
easat-2730	292	22	rats	rat	NOUN
easat-2730	292	23	[	[	X
easat-2730	292	24	48	48	NUM
easat-2730	292	25	]	]	PUNCT
easat-2730	292	26	.	.	PUNCT
easat-2730	293	1	it	it	PRON
easat-2730	293	2	has	have	AUX
easat-2730	293	3	been	be	AUX
easat-2730	293	4	proposed	propose	VERB
easat-2730	293	5	that	that	SCONJ
easat-2730	293	6	the	the	DET
easat-2730	293	7	enhancement	enhancement	NOUN
easat-2730	293	8	of	of	ADP
easat-2730	293	9	no	no	DET
easat-2730	293	10	function	function	NOUN
easat-2730	293	11	might	might	AUX
easat-2730	293	12	be	be	AUX
easat-2730	293	13	associated	associate	VERB
easat-2730	293	14	to	to	ADP
easat-2730	293	15	the	the	DET
easat-2730	293	16	decrease	decrease	NOUN
easat-2730	293	17	in	in	ADP
easat-2730	293	18	oxidative	oxidative	ADJ
easat-2730	293	19	stress	stress	NOUN
easat-2730	293	20	brought	bring	VERB
easat-2730	293	21	by	by	ADP
easat-2730	293	22	pe	pe	PROPN
easat-2730	293	23	.	.	PUNCT
easat-2730	294	1	previous	previous	ADJ
easat-2730	294	2	studies	study	NOUN
easat-2730	294	3	demonstrated	demonstrate	VERB
easat-2730	294	4	that	that	SCONJ
easat-2730	294	5	water	water	NOUN
easat-2730	294	6	-	-	PUNCT
easat-2730	294	7	based	base	VERB
easat-2730	294	8	exercises	exercise	NOUN
easat-2730	294	9	boosted	boost	VERB
easat-2730	294	10	no	no	DET
easat-2730	294	11	metabolism	metabolism	NOUN
easat-2730	294	12	by	by	ADP
easat-2730	294	13	enhancing	enhance	VERB
easat-2730	294	14	endothelial	endothelial	ADJ
easat-2730	294	15	function	function	NOUN
easat-2730	294	16	and	and	CCONJ
easat-2730	294	17	cardiorespiratory	cardiorespiratory	NOUN
easat-2730	294	18	capacity	capacity	NOUN
easat-2730	294	19	in	in	ADP
easat-2730	294	20	individuals	individual	NOUN
easat-2730	294	21	with	with	ADP
easat-2730	294	22	chronic	chronic	ADJ
easat-2730	294	23	heart	heart	NOUN
easat-2730	294	24	failure	failure	NOUN
easat-2730	294	25	and	and	CCONJ
easat-2730	294	26	coronary	coronary	ADJ
easat-2730	294	27	artery	artery	NOUN
easat-2730	294	28	disease	disease	NOUN
easat-2730	294	29	[	[	X
easat-2730	294	30	48	48	NUM
easat-2730	294	31	]	]	PUNCT
easat-2730	294	32	.	.	PUNCT
easat-2730	295	1	pe	pe	PROPN
easat-2730	295	2	has	have	VERB
easat-2730	295	3	cardioprotective	cardioprotective	ADJ
easat-2730	295	4	effects	effect	NOUN
easat-2730	295	5	,	,	PUNCT
easat-2730	295	6	as	as	SCONJ
easat-2730	295	7	shown	show	VERB
easat-2730	295	8	by	by	ADP
easat-2730	295	9	the	the	DET
easat-2730	295	10	increase	increase	NOUN
easat-2730	295	11	in	in	ADP
easat-2730	295	12	no	no	DET
easat-2730	295	13	metabolite	metabolite	NOUN
easat-2730	295	14	concentrations	concentration	NOUN
easat-2730	295	15	and	and	CCONJ
easat-2730	295	16	decrease	decrease	NOUN
easat-2730	295	17	in	in	ADP
easat-2730	295	18	mi	mi	PROPN
easat-2730	295	19	following	follow	VERB
easat-2730	295	20	high	high	ADJ
easat-2730	295	21	-	-	PUNCT
easat-2730	295	22	intensity	intensity	NOUN
easat-2730	295	23	interval	interval	NOUN
easat-2730	295	24	training	training	NOUN
easat-2730	295	25	in	in	ADP
easat-2730	295	26	ischemic	ischemic	ADJ
easat-2730	295	27	rats	rat	NOUN
easat-2730	295	28	[	[	X
easat-2730	295	29	43	43	NUM
easat-2730	295	30	]	]	PUNCT
easat-2730	295	31	.	.	PUNCT
easat-2730	296	1	the	the	DET
easat-2730	296	2	impacts	impact	NOUN
easat-2730	296	3	of	of	ADP
easat-2730	296	4	pe	pe	PRON
easat-2730	296	5	on	on	ADP
easat-2730	296	6	no	no	DET
easat-2730	296	7	generation	generation	NOUN
easat-2730	296	8	have	have	AUX
easat-2730	296	9	been	be	AUX
easat-2730	296	10	attributed	attribute	VERB
easat-2730	296	11	to	to	ADP
easat-2730	296	12	several	several	ADJ
easat-2730	296	13	molecular	molecular	ADJ
easat-2730	296	14	processes	process	NOUN
easat-2730	296	15	,	,	PUNCT
easat-2730	296	16	including	include	VERB
easat-2730	296	17	the	the	DET
easat-2730	296	18	phosphorylation	phosphorylation	NOUN
easat-2730	296	19	state	state	NOUN
easat-2730	296	20	and	and	CCONJ
easat-2730	296	21	enos	eno	VERB
easat-2730	296	22	transcription	transcription	NOUN
easat-2730	296	23	rate	rate	NOUN
easat-2730	296	24	.	.	PUNCT
easat-2730	297	1	for	for	ADP
easat-2730	297	2	instance	instance	NOUN
easat-2730	297	3	,	,	PUNCT
easat-2730	297	4	it	it	PRON
easat-2730	297	5	was	be	AUX
easat-2730	297	6	discovered	discover	VERB
easat-2730	297	7	that	that	SCONJ
easat-2730	297	8	enos	enos	PROPN
easat-2730	297	9	mrna	mrna	PROPN
easat-2730	297	10	levels	level	NOUN
easat-2730	297	11	were	be	AUX
easat-2730	297	12	elevated	elevate	VERB
easat-2730	297	13	in	in	ADP
easat-2730	297	14	rats	rat	NOUN
easat-2730	297	15	that	that	PRON
easat-2730	297	16	underwent	undergo	VERB
easat-2730	297	17	both	both	CCONJ
easat-2730	297	18	acute	acute	ADJ
easat-2730	297	19	and	and	CCONJ
easat-2730	297	20	long	long	ADJ
easat-2730	297	21	-	-	PUNCT
easat-2730	297	22	term	term	NOUN
easat-2730	297	23	aerobic	aerobic	ADJ
easat-2730	297	24	training	training	NOUN
easat-2730	297	25	.	.	PUNCT
easat-2730	298	1	previous	previous	ADJ
easat-2730	298	2	studies	study	NOUN
easat-2730	298	3	have	have	AUX
easat-2730	298	4	shown	show	VERB
easat-2730	298	5	that	that	SCONJ
easat-2730	298	6	exercise	exercise	NOUN
easat-2730	298	7	might	might	AUX
easat-2730	298	8	enhance	enhance	VERB
easat-2730	298	9	cardiac	cardiac	ADJ
easat-2730	298	10	function	function	NOUN
easat-2730	298	11	in	in	ADP
easat-2730	298	12	ischemic	ischemic	ADJ
easat-2730	298	13	rats	rat	NOUN
easat-2730	298	14	through	through	ADP
easat-2730	298	15	the	the	DET
easat-2730	298	16	β3	β3	ADJ
easat-2730	298	17	adrenoreceptor	adrenoreceptor	NOUN
easat-2730	298	18	by	by	ADP
easat-2730	298	19	raising	raise	VERB
easat-2730	298	20	the	the	DET
easat-2730	298	21	enos	enos	PROPN
easat-2730	298	22	phosphorylation	phosphorylation	NOUN
easat-2730	299	1	[	[	X
easat-2730	299	2	9	9	NUM
easat-2730	299	3	]	]	PUNCT
easat-2730	299	4	.	.	PUNCT
easat-2730	300	1	some	some	DET
easat-2730	300	2	researchers	researcher	NOUN
easat-2730	300	3	have	have	AUX
easat-2730	300	4	emphasized	emphasize	VERB
easat-2730	300	5	the	the	DET
easat-2730	300	6	involvement	involvement	NOUN
easat-2730	300	7	of	of	ADP
easat-2730	300	8	the	the	DET
easat-2730	300	9	β3	β3	ADJ
easat-2730	300	10	adrenoreceptor	adrenoreceptor	NOUN
easat-2730	300	11	in	in	ADP
easat-2730	300	12	mediating	mediate	VERB
easat-2730	300	13	the	the	DET
easat-2730	300	14	activities	activity	NOUN
easat-2730	300	15	of	of	ADP
easat-2730	300	16	pe	pe	PRON
easat-2730	300	17	on	on	ADP
easat-2730	300	18	the	the	DET
easat-2730	300	19	no	no	DET
easat-2730	300	20	generation	generation	NOUN
easat-2730	300	21	.	.	PUNCT
easat-2730	301	1	in	in	ADP
easat-2730	301	2	this	this	DET
easat-2730	301	3	regard	regard	NOUN
easat-2730	301	4	,	,	PUNCT
easat-2730	301	5	other	other	ADJ
easat-2730	301	6	investigators	investigator	NOUN
easat-2730	301	7	suggested	suggest	VERB
easat-2730	301	8	that	that	SCONJ
easat-2730	301	9	a	a	DET
easat-2730	301	10	significant	significant	ADJ
easat-2730	301	11	amount	amount	NOUN
easat-2730	301	12	of	of	ADP
easat-2730	301	13	enos	eno	NOUN
easat-2730	301	14	uncoupling	uncouple	VERB
easat-2730	301	15	might	might	AUX
easat-2730	301	16	be	be	AUX
easat-2730	301	17	needed	need	VERB
easat-2730	301	18	for	for	ADP
easat-2730	301	19	exercise	exercise	NOUN
easat-2730	301	20	-	-	PUNCT
easat-2730	301	21	induced	induce	VERB
easat-2730	301	22	myocardial	myocardial	ADJ
easat-2730	301	23	cardio	cardio	NOUN
easat-2730	301	24	-	-	PUNCT
easat-2730	301	25	protection	protection	NOUN
easat-2730	301	26	in	in	ADP
easat-2730	301	27	ischemia	ischemia	NOUN
easat-2730	301	28	-	-	PUNCT
easat-2730	301	29	reperfusion	reperfusion	NOUN
easat-2730	301	30	[	[	X
easat-2730	301	31	49	49	NUM
easat-2730	301	32	]	]	PUNCT
easat-2730	301	33	.	.	PUNCT
easat-2730	302	1	finally	finally	ADV
easat-2730	302	2	,	,	PUNCT
easat-2730	302	3	vascular	vascular	ADJ
easat-2730	302	4	endothelium	endothelium	NOUN
easat-2730	302	5	is	be	AUX
easat-2730	302	6	perhaps	perhaps	ADV
easat-2730	302	7	the	the	DET
easat-2730	302	8	most	most	ADV
easat-2730	302	9	crucial	crucial	ADJ
easat-2730	302	10	body	body	NOUN
easat-2730	302	11	defence	defence	NOUN
easat-2730	302	12	mechanism	mechanism	NOUN
easat-2730	302	13	against	against	ADP
easat-2730	302	14	obesityinduced	obesityinduce	VERB
easat-2730	302	15	endothelial	endothelial	ADJ
easat-2730	302	16	dysfunction	dysfunction	NOUN
easat-2730	302	17	,	,	PUNCT
easat-2730	302	18	which	which	PRON
easat-2730	302	19	can	can	AUX
easat-2730	302	20	result	result	VERB
easat-2730	302	21	in	in	ADP
easat-2730	302	22	atherothrombotic	atherothrombotic	PROPN
easat-2730	302	23	cvds	cvds	PROPN
easat-2730	302	24	,	,	PUNCT
easat-2730	302	25	as	as	SCONJ
easat-2730	302	26	shown	show	VERB
easat-2730	302	27	by	by	ADP
easat-2730	302	28	the	the	DET
easat-2730	302	29	aforementioned	aforementioned	ADJ
easat-2730	302	30	sources	source	NOUN
easat-2730	302	31	[	[	X
easat-2730	302	32	6	6	NUM
easat-2730	302	33	]	]	PUNCT
easat-2730	302	34	.	.	PUNCT
easat-2730	303	1	determination	determination	NOUN
easat-2730	303	2	of	of	ADP
easat-2730	303	3	the	the	DET
easat-2730	303	4	obesity	obesity	NOUN
easat-2730	303	5	-	-	PUNCT
easat-2730	303	6	induced	induce	VERB
easat-2730	303	7	endothelial	endothelial	ADJ
easat-2730	303	8	function	function	NOUN
easat-2730	303	9	in	in	ADP
easat-2730	303	10	humans	human	NOUN
easat-2730	303	11	,	,	PUNCT
easat-2730	303	12	3453	3453	NUM
easat-2730	303	13	edelweiss	edelweiss	PROPN
easat-2730	303	14	applied	apply	VERB
easat-2730	303	15	science	science	NOUN
easat-2730	303	16	and	and	CCONJ
easat-2730	303	17	technology	technology	NOUN
easat-2730	303	18	issn	issn	PROPN
easat-2730	303	19	:	:	PUNCT
easat-2730	303	20	2576	2576	NUM
easat-2730	303	21	-	-	SYM
easat-2730	303	22	8484	8484	NUM
easat-2730	303	23	vol	vol	NOUN
easat-2730	303	24	.	.	PROPN
easat-2730	303	25	8	8	NUM
easat-2730	303	26	,	,	PUNCT
easat-2730	303	27	no	no	INTJ
easat-2730	303	28	.	.	NOUN
easat-2730	304	1	6	6	NUM
easat-2730	304	2	:	:	SYM
easat-2730	304	3	3441	3441	NUM
easat-2730	304	4	-	-	SYM
easat-2730	304	5	3456	3456	NUM
easat-2730	304	6	,	,	PUNCT
easat-2730	304	7	2024	2024	NUM
easat-2730	304	8	doi	doi	NOUN
easat-2730	304	9	:	:	PUNCT
easat-2730	304	10	10.55214/25768484.v8i6.2730	10.55214/25768484.v8i6.2730	NUM
easat-2730	304	11	©	©	ADP
easat-2730	304	12	2024	2024	NUM
easat-2730	304	13	by	by	ADP
easat-2730	304	14	the	the	DET
easat-2730	304	15	authors	author	NOUN
easat-2730	304	16	;	;	PUNCT
easat-2730	304	17	licensee	licensee	PROPN
easat-2730	304	18	learning	learn	VERB
easat-2730	304	19	gate	gate	PROPN
easat-2730	304	20	appears	appear	VERB
easat-2730	304	21	to	to	PART
easat-2730	304	22	be	be	AUX
easat-2730	304	23	predictive	predictive	ADJ
easat-2730	304	24	,	,	PUNCT
easat-2730	304	25	and	and	CCONJ
easat-2730	304	26	therapeutic	therapeutic	ADJ
easat-2730	304	27	interventions	intervention	NOUN
easat-2730	304	28	that	that	PRON
easat-2730	304	29	boost	boost	VERB
easat-2730	304	30	the	the	DET
easat-2730	304	31	bioavailability	bioavailability	NOUN
easat-2730	304	32	of	of	ADP
easat-2730	304	33	vascular	vascular	ADJ
easat-2730	304	34	endothelial	endothelial	NOUN
easat-2730	304	35	no	no	PRON
easat-2730	304	36	may	may	AUX
easat-2730	304	37	enhance	enhance	VERB
easat-2730	304	38	long	long	ADJ
easat-2730	304	39	-	-	PUNCT
easat-2730	304	40	term	term	NOUN
easat-2730	304	41	outcomes	outcome	NOUN
easat-2730	304	42	in	in	ADP
easat-2730	304	43	normal	normal	ADJ
easat-2730	304	44	individuals	individual	NOUN
easat-2730	304	45	,	,	PUNCT
easat-2730	304	46	high	high	ADJ
easat-2730	304	47	-	-	PUNCT
easat-2730	304	48	risk	risk	NOUN
easat-2730	304	49	subjects	subject	NOUN
easat-2730	304	50	,	,	PUNCT
easat-2730	304	51	or	or	CCONJ
easat-2730	304	52	those	those	PRON
easat-2730	304	53	who	who	PRON
easat-2730	304	54	have	have	VERB
easat-2730	304	55	endothelial	endothelial	ADJ
easat-2730	304	56	dysfunction	dysfunction	NOUN
easat-2730	304	57	that	that	PRON
easat-2730	304	58	leads	lead	VERB
easat-2730	304	59	to	to	ADP
easat-2730	304	60	obesity	obesity	NOUN
easat-2730	304	61	-	-	PUNCT
easat-2730	304	62	induced	induce	VERB
easat-2730	304	63	atherosclerotic	atherosclerotic	ADJ
easat-2730	304	64	cvds	cvds	NOUN
easat-2730	305	1	[	[	X
easat-2730	305	2	50	50	NUM
easat-2730	305	3	]	]	PUNCT
easat-2730	305	4	.	.	PUNCT
easat-2730	306	1	insulin	insulin	NOUN
easat-2730	306	2	sensitizers	sensitizer	NOUN
easat-2730	306	3	,	,	PUNCT
easat-2730	306	4	novel	novel	ADJ
easat-2730	306	5	antioxidant	antioxidant	ADJ
easat-2730	306	6	compounds	compound	NOUN
easat-2730	306	7	,	,	PUNCT
easat-2730	306	8	or	or	CCONJ
easat-2730	306	9	combinations	combination	NOUN
easat-2730	306	10	of	of	ADP
easat-2730	306	11	classic	classic	ADJ
easat-2730	306	12	antioxidant	antioxidant	ADJ
easat-2730	306	13	agents	agent	NOUN
easat-2730	306	14	,	,	PUNCT
easat-2730	306	15	as	as	ADV
easat-2730	306	16	well	well	ADV
easat-2730	306	17	as	as	ADP
easat-2730	306	18	drugs	drug	NOUN
easat-2730	306	19	that	that	PRON
easat-2730	306	20	target	target	VERB
easat-2730	306	21	endothelial	endothelial	NOUN
easat-2730	306	22	no	no	DET
easat-2730	306	23	synthase	synthase	NOUN
easat-2730	306	24	"	"	PUNCT
easat-2730	306	25	coupling	coupling	NOUN
easat-2730	306	26	"	"	PUNCT
easat-2730	306	27	are	be	AUX
easat-2730	306	28	some	some	PRON
easat-2730	306	29	of	of	ADP
easat-2730	306	30	the	the	DET
easat-2730	306	31	more	more	ADV
easat-2730	306	32	recent	recent	ADJ
easat-2730	306	33	therapeutic	therapeutic	ADJ
easat-2730	306	34	strategies	strategy	NOUN
easat-2730	306	35	that	that	PRON
easat-2730	306	36	target	target	VERB
easat-2730	306	37	endothelial	endothelial	ADJ
easat-2730	306	38	dysfunction	dysfunction	NOUN
easat-2730	306	39	in	in	ADP
easat-2730	306	40	certain	certain	ADJ
easat-2730	306	41	disease	disease	NOUN
easat-2730	306	42	conditions	condition	NOUN
easat-2730	306	43	.	.	PUNCT
easat-2730	307	1	the	the	DET
easat-2730	307	2	identification	identification	NOUN
easat-2730	307	3	of	of	ADP
easat-2730	307	4	prospective	prospective	ADJ
easat-2730	307	5	responders	responder	NOUN
easat-2730	307	6	to	to	ADP
easat-2730	307	7	therapies	therapy	NOUN
easat-2730	307	8	that	that	PRON
easat-2730	307	9	target	target	VERB
easat-2730	307	10	particular	particular	ADJ
easat-2730	307	11	intracellular	intracellular	ADJ
easat-2730	307	12	pathways	pathway	NOUN
easat-2730	307	13	in	in	ADP
easat-2730	307	14	the	the	DET
easat-2730	307	15	vascular	vascular	ADJ
easat-2730	307	16	endothelium	endothelium	NOUN
easat-2730	307	17	may	may	AUX
easat-2730	307	18	one	one	NUM
easat-2730	307	19	day	day	NOUN
easat-2730	307	20	be	be	AUX
easat-2730	307	21	aided	aid	VERB
easat-2730	307	22	by	by	ADP
easat-2730	307	23	genetic	genetic	ADJ
easat-2730	307	24	profiles	profile	NOUN
easat-2730	307	25	[	[	X
easat-2730	307	26	6	6	NUM
easat-2730	307	27	,	,	PUNCT
easat-2730	307	28	51	51	NUM
easat-2730	307	29	]	]	PUNCT
easat-2730	307	30	.	.	PUNCT
easat-2730	308	1	4	4	X
easat-2730	308	2	.	.	X
easat-2730	308	3	conclusion	conclusion	NOUN
easat-2730	308	4	it	it	PRON
easat-2730	308	5	is	be	AUX
easat-2730	308	6	very	very	ADV
easat-2730	308	7	clear	clear	ADJ
easat-2730	308	8	that	that	SCONJ
easat-2730	308	9	no	no	PRON
easat-2730	308	10	plays	play	VERB
easat-2730	308	11	a	a	DET
easat-2730	308	12	key	key	ADJ
easat-2730	308	13	role	role	NOUN
easat-2730	308	14	in	in	ADP
easat-2730	308	15	mediating	mediate	VERB
easat-2730	308	16	several	several	ADJ
easat-2730	308	17	endothelial	endothelial	ADJ
easat-2730	308	18	regulatory	regulatory	ADJ
easat-2730	308	19	functions	function	NOUN
easat-2730	308	20	.	.	PUNCT
easat-2730	309	1	it	it	PRON
easat-2730	309	2	is	be	AUX
easat-2730	309	3	also	also	ADV
easat-2730	309	4	becoming	become	VERB
easat-2730	309	5	certain	certain	ADJ
easat-2730	309	6	that	that	SCONJ
easat-2730	309	7	several	several	ADJ
easat-2730	309	8	conditions	condition	NOUN
easat-2730	309	9	which	which	PRON
easat-2730	309	10	are	be	AUX
easat-2730	309	11	thought	think	VERB
easat-2730	309	12	to	to	PART
easat-2730	309	13	be	be	AUX
easat-2730	309	14	"	"	PUNCT
easat-2730	309	15	risk	risk	NOUN
easat-2730	309	16	factors	factor	NOUN
easat-2730	309	17	"	"	PUNCT
easat-2730	309	18	for	for	ADP
easat-2730	309	19	obesity	obesity	NOUN
easat-2730	309	20	-	-	PUNCT
easat-2730	309	21	induced	induce	VERB
easat-2730	309	22	endothelial	endothelial	ADJ
easat-2730	309	23	dysfunction	dysfunction	NOUN
easat-2730	309	24	,	,	PUNCT
easat-2730	309	25	leading	lead	VERB
easat-2730	309	26	to	to	ADP
easat-2730	309	27	atherothrombotic	atherothrombotic	PROPN
easat-2730	309	28	cvds	cvds	PROPN
easat-2730	309	29	may	may	AUX
easat-2730	309	30	be	be	AUX
easat-2730	309	31	associated	associate	VERB
easat-2730	309	32	with	with	ADP
easat-2730	309	33	the	the	DET
easat-2730	309	34	reduction	reduction	NOUN
easat-2730	309	35	in	in	ADP
easat-2730	309	36	no	no	DET
easat-2730	309	37	bioavailability	bioavailability	NOUN
easat-2730	309	38	.	.	PUNCT
easat-2730	310	1	obesity	obesity	NOUN
easat-2730	310	2	-	-	PUNCT
easat-2730	310	3	induced	induce	VERB
easat-2730	310	4	endothelial	endothelial	ADJ
easat-2730	310	5	dysfunctions	dysfunction	NOUN
easat-2730	310	6	have	have	AUX
easat-2730	310	7	been	be	AUX
easat-2730	310	8	linked	link	VERB
easat-2730	310	9	to	to	ADP
easat-2730	310	10	an	an	DET
easat-2730	310	11	increasing	increase	VERB
easat-2730	310	12	number	number	NOUN
easat-2730	310	13	of	of	ADP
easat-2730	310	14	diseases	disease	NOUN
easat-2730	310	15	,	,	PUNCT
easat-2730	310	16	such	such	ADJ
easat-2730	310	17	as	as	ADP
easat-2730	310	18	hypercholesterolemia	hypercholesterolemia	NOUN
easat-2730	310	19	,	,	PUNCT
easat-2730	310	20	hyperlipidaemia	hyperlipidaemia	NOUN
easat-2730	310	21	,	,	PUNCT
easat-2730	310	22	systemic	systemic	ADJ
easat-2730	310	23	hypertension	hypertension	NOUN
easat-2730	310	24	,	,	PUNCT
easat-2730	310	25	smoking	smoking	NOUN
easat-2730	310	26	,	,	PUNCT
easat-2730	310	27	dm	dm	NOUN
easat-2730	310	28	,	,	PUNCT
easat-2730	310	29	and	and	CCONJ
easat-2730	310	30	congestive	congestive	ADJ
easat-2730	310	31	heart	heart	NOUN
easat-2730	310	32	failure	failure	NOUN
easat-2730	310	33	.	.	PUNCT
easat-2730	311	1	therefore	therefore	ADV
easat-2730	311	2	,	,	PUNCT
easat-2730	311	3	under	under	ADP
easat-2730	311	4	these	these	DET
easat-2730	311	5	conditions	condition	NOUN
easat-2730	311	6	,	,	PUNCT
easat-2730	311	7	the	the	DET
easat-2730	311	8	vascular	vascular	ADJ
easat-2730	311	9	endothelial	endothelial	NOUN
easat-2730	311	10	wall	wall	NOUN
easat-2730	311	11	may	may	AUX
easat-2730	311	12	promote	promote	VERB
easat-2730	311	13	inflammatory	inflammatory	ADJ
easat-2730	311	14	processes	process	NOUN
easat-2730	311	15	,	,	PUNCT
easat-2730	311	16	such	such	ADJ
easat-2730	311	17	as	as	ADP
easat-2730	311	18	lipoprotein	lipoprotein	ADJ
easat-2730	311	19	oxidation	oxidation	NOUN
easat-2730	311	20	,	,	PUNCT
easat-2730	311	21	smooth	smooth	ADJ
easat-2730	311	22	muscle	muscle	NOUN
easat-2730	311	23	proliferation	proliferation	NOUN
easat-2730	311	24	,	,	PUNCT
easat-2730	311	25	extracellular	extracellular	ADJ
easat-2730	311	26	matrix	matrix	NOUN
easat-2730	311	27	accumulation	accumulation	NOUN
easat-2730	311	28	or	or	CCONJ
easat-2730	311	29	lysis	lysis	NOUN
easat-2730	311	30	,	,	PUNCT
easat-2730	311	31	deposition	deposition	NOUN
easat-2730	311	32	of	of	ADP
easat-2730	311	33	lipid	lipid	NOUN
easat-2730	311	34	-	-	PUNCT
easat-2730	311	35	rich	rich	ADJ
easat-2730	311	36	material	material	NOUN
easat-2730	311	37	,	,	PUNCT
easat-2730	311	38	platelet	platelet	NOUN
easat-2730	311	39	activation	activation	NOUN
easat-2730	311	40	,	,	PUNCT
easat-2730	311	41	and	and	CCONJ
easat-2730	311	42	thrombus	thrombus	NOUN
easat-2730	311	43	generation	generation	NOUN
easat-2730	311	44	.	.	PUNCT
easat-2730	312	1	these	these	DET
easat-2730	312	2	obesity	obesity	NOUN
easat-2730	312	3	-	-	PUNCT
easat-2730	312	4	induced	induce	VERB
easat-2730	312	5	related	relate	VERB
easat-2730	312	6	endothelial	endothelial	NOUN
easat-2730	312	7	dysfunctions	dysfunction	NOUN
easat-2730	312	8	could	could	AUX
easat-2730	312	9	influence	influence	VERB
easat-2730	312	10	the	the	DET
easat-2730	312	11	onset	onset	NOUN
easat-2730	312	12	and	and	CCONJ
easat-2730	312	13	clinical	clinical	ADJ
easat-2730	312	14	manifestation	manifestation	NOUN
easat-2730	312	15	of	of	ADP
easat-2730	312	16	atherosclerosis	atherosclerosis	NOUN
easat-2730	312	17	,	,	PUNCT
easat-2730	312	18	progressing	progress	VERB
easat-2730	312	19	to	to	PART
easat-2730	312	20	cvds	cvds	PROPN
easat-2730	312	21	.	.	PUNCT
easat-2730	313	1	new	new	ADJ
easat-2730	313	2	treatment	treatment	NOUN
easat-2730	313	3	approaches	approach	VERB
easat-2730	313	4	for	for	ADP
easat-2730	313	5	various	various	ADJ
easat-2730	313	6	cvds	cvds	NOUN
easat-2730	313	7	are	be	AUX
easat-2730	313	8	anticipated	anticipate	VERB
easat-2730	313	9	to	to	PART
easat-2730	313	10	result	result	VERB
easat-2730	313	11	from	from	ADP
easat-2730	313	12	the	the	DET
easat-2730	313	13	interactions	interaction	NOUN
easat-2730	313	14	that	that	PRON
easat-2730	313	15	boost	boost	VERB
easat-2730	313	16	endogenous	endogenous	ADJ
easat-2730	313	17	no	no	DET
easat-2730	313	18	production	production	NOUN
easat-2730	313	19	,	,	PUNCT
easat-2730	313	20	function	function	NOUN
easat-2730	313	21	or	or	CCONJ
easat-2730	313	22	complement	complement	VERB
easat-2730	313	23	it	it	PRON
easat-2730	313	24	with	with	ADP
easat-2730	313	25	exogenous	exogenous	ADJ
easat-2730	313	26	no	no	NOUN
easat-2730	313	27	.	.	PUNCT
easat-2730	314	1	additional	additional	ADJ
easat-2730	314	2	research	research	NOUN
easat-2730	314	3	is	be	AUX
easat-2730	314	4	required	require	VERB
easat-2730	314	5	to	to	PART
easat-2730	314	6	confirm	confirm	VERB
easat-2730	314	7	the	the	DET
easat-2730	314	8	validity	validity	NOUN
easat-2730	314	9	of	of	ADP
easat-2730	314	10	various	various	ADJ
easat-2730	314	11	treatments	treatment	NOUN
easat-2730	314	12	that	that	PRON
easat-2730	314	13	appeared	appear	VERB
easat-2730	314	14	to	to	PART
easat-2730	314	15	be	be	AUX
easat-2730	314	16	helpful	helpful	ADJ
easat-2730	314	17	in	in	ADP
easat-2730	314	18	restoring	restore	VERB
easat-2730	314	19	endothelial	endothelial	ADJ
easat-2730	314	20	function	function	NOUN
easat-2730	314	21	.	.	PUNCT
easat-2730	315	1	funding	funding	NOUN
easat-2730	315	2	:	:	PUNCT
easat-2730	315	3	this	this	DET
easat-2730	315	4	review	review	NOUN
easat-2730	315	5	was	be	AUX
easat-2730	315	6	sponsored	sponsor	VERB
easat-2730	315	7	by	by	ADP
easat-2730	315	8	the	the	DET
easat-2730	315	9	universiti	universiti	PROPN
easat-2730	315	10	putra	putra	PROPN
easat-2730	315	11	malaysia	malaysia	PROPN
easat-2730	315	12	(	(	PUNCT
easat-2730	315	13	upm	upm	PROPN
easat-2730	315	14	)	)	PUNCT
easat-2730	315	15	,	,	PUNCT
easat-2730	315	16	faculty	faculty	NOUN
easat-2730	315	17	of	of	ADP
easat-2730	315	18	medicine	medicine	NOUN
easat-2730	315	19	and	and	CCONJ
easat-2730	315	20	health	health	NOUN
easat-2730	315	21	sciences	science	NOUN
easat-2730	315	22	,	,	PUNCT
easat-2730	315	23	under	under	ADP
easat-2730	315	24	ips	ips	NOUN
easat-2730	315	25	(	(	PUNCT
easat-2730	315	26	upm/800	upm/800	PROPN
easat-2730	315	27	-	-	PUNCT
easat-2730	315	28	3/3/1	3/3/1	NUM
easat-2730	315	29	/	/	SYM
easat-2730	315	30	gp	gp	NOUN
easat-2730	315	31	-	-	PUNCT
easat-2730	315	32	ips/2020/9686500	ips/2020/9686500	NOUN
easat-2730	315	33	)	)	PUNCT
easat-2730	315	34	grant	grant	NOUN
easat-2730	315	35	,	,	PUNCT
easat-2730	315	36	office	office	NOUN
easat-2730	315	37	of	of	ADP
easat-2730	315	38	the	the	DET
easat-2730	315	39	vice	vice	NOUN
easat-2730	315	40	-	-	NOUN
easat-2730	315	41	chancellor	chancellor	NOUN
easat-2730	315	42	(	(	PUNCT
easat-2730	315	43	research	research	NOUN
easat-2730	315	44	and	and	CCONJ
easat-2730	315	45	innovation	innovation	NOUN
easat-2730	315	46	)	)	PUNCT
easat-2730	315	47	,	,	PUNCT
easat-2730	315	48	upm	upm	PROPN
easat-2730	315	49	,	,	PUNCT
easat-2730	315	50	malaysia	malaysia	PROPN
easat-2730	315	51	.	.	PUNCT
easat-2730	316	1	acknowledgement	acknowledgement	NOUN
easat-2730	316	2	:	:	PUNCT
easat-2730	316	3	the	the	DET
easat-2730	316	4	hard	hard	ADJ
easat-2730	316	5	work	work	NOUN
easat-2730	316	6	of	of	ADP
easat-2730	316	7	the	the	DET
easat-2730	316	8	school	school	NOUN
easat-2730	316	9	for	for	ADP
easat-2730	316	10	postgraduate	postgraduate	NOUN
easat-2730	316	11	studies	study	NOUN
easat-2730	316	12	,	,	PUNCT
easat-2730	316	13	upm	upm	NOUN
easat-2730	316	14	,	,	PUNCT
easat-2730	316	15	and	and	CCONJ
easat-2730	316	16	the	the	DET
easat-2730	316	17	management	management	NOUN
easat-2730	316	18	of	of	ADP
easat-2730	316	19	upm	upm	NOUN
easat-2730	316	20	,	,	PUNCT
easat-2730	316	21	for	for	ADP
easat-2730	316	22	admission	admission	NOUN
easat-2730	316	23	offer	offer	NOUN
easat-2730	316	24	and	and	CCONJ
easat-2730	316	25	encouragement	encouragement	NOUN
easat-2730	316	26	to	to	PART
easat-2730	316	27	write	write	VERB
easat-2730	316	28	this	this	DET
easat-2730	316	29	little	little	ADJ
easat-2730	316	30	manuscript	manuscript	NOUN
easat-2730	316	31	with	with	ADP
easat-2730	316	32	the	the	DET
easat-2730	316	33	automatic	automatic	ADJ
easat-2730	316	34	grantee	grantee	NOUN
easat-2730	316	35	to	to	PART
easat-2730	316	36	pay	pay	VERB
easat-2730	316	37	for	for	ADP
easat-2730	316	38	its	its	PRON
easat-2730	316	39	publication	publication	NOUN
easat-2730	316	40	charges	charge	NOUN
easat-2730	316	41	,	,	PUNCT
easat-2730	316	42	are	be	AUX
easat-2730	316	43	highly	highly	ADV
easat-2730	316	44	appreciated	appreciated	ADJ
easat-2730	316	45	.	.	PUNCT
easat-2730	317	1	abbreviations	abbreviation	NOUN
easat-2730	317	2	:	:	PUNCT
easat-2730	317	3	icam-1	icam-1	NUM
easat-2730	317	4	intercellular	intercellular	ADJ
easat-2730	317	5	adhesion	adhesion	NOUN
easat-2730	317	6	molecule-1	molecule-1	PROPN
easat-2730	317	7	vcam	vcam	NOUN
easat-2730	317	8	-	-	PUNCT
easat-2730	317	9	i	i	PRON
easat-2730	317	10	vascular	vascular	ADJ
easat-2730	317	11	cell	cell	NOUN
easat-2730	317	12	adhesion	adhesion	NOUN
easat-2730	317	13	molecule-1	molecule-1	PROPN
easat-2730	317	14	jnk	jnk	PROPN
easat-2730	317	15	–	–	PUNCT
easat-2730	317	16	c	c	PROPN
easat-2730	317	17	jun	jun	PROPN
easat-2730	317	18	n	n	CCONJ
easat-2730	317	19	-	-	PUNCT
easat-2730	317	20	terminal	terminal	ADJ
easat-2730	317	21	kinase	kinase	NOUN
easat-2730	317	22	tf	tf	PROPN
easat-2730	317	23	tissue	tissue	NOUN
easat-2730	317	24	factor	factor	NOUN
easat-2730	317	25	il-10	il-10	X
easat-2730	317	26	interleukin-10	interleukin-10	PROPN
easat-2730	317	27	ros	ros	PROPN
easat-2730	317	28	reactive	reactive	ADJ
easat-2730	317	29	oxygen	oxygen	NOUN
easat-2730	317	30	species	specie	NOUN
easat-2730	317	31	vegf	vegf	NOUN
easat-2730	317	32	vascular	vascular	ADJ
easat-2730	317	33	endothelial	endothelial	ADJ
easat-2730	317	34	growth	growth	NOUN
easat-2730	317	35	factor	factor	NOUN
easat-2730	317	36	tnf	tnf	PROPN
easat-2730	317	37	-	-	PUNCT
easat-2730	317	38	α	α	PROPN
easat-2730	317	39	tumour	tumour	NOUN
easat-2730	317	40	necrosis	necrosis	NOUN
easat-2730	317	41	factor	factor	NOUN
easat-2730	317	42	-	-	PUNCT
easat-2730	317	43	α	α	NOUN
easat-2730	317	44	pgl2	pgl2	ADJ
easat-2730	317	45	prostacyclin	prostacyclin	NOUN
easat-2730	317	46	il-6	il-6	PRON
easat-2730	317	47	interleukin-6	interleukin-6	NUM
easat-2730	317	48	ccl	ccl	PROPN
easat-2730	317	49	chemokine	chemokine	PROPN
easat-2730	317	50	(	(	PUNCT
easat-2730	317	51	c	c	NOUN
easat-2730	317	52	-	-	PUNCT
easat-2730	317	53	c	c	NOUN
easat-2730	317	54	motif	motif	NOUN
easat-2730	317	55	)	)	PUNCT
easat-2730	317	56	ligand	ligand	NOUN
easat-2730	317	57	,	,	PUNCT
easat-2730	317	58	ec	ec	PROPN
easat-2730	317	59	endothelial	endothelial	NOUN
easat-2730	317	60	cells	cell	NOUN
easat-2730	317	61	et1	et1	VERB
easat-2730	318	1	endothelin-1	endothelin-1	NUM
easat-2730	318	2	fgf	fgf	PROPN
easat-2730	318	3	fibroblast	fibroblast	ADJ
easat-2730	318	4	growth	growth	NOUN
easat-2730	318	5	factor	factor	NOUN
easat-2730	318	6	h2s	h2s	NOUN
easat-2730	318	7	hydrogen	hydrogen	NOUN
easat-2730	318	8	sulfide	sulfide	NOUN
easat-2730	318	9	pgh2	pgh2	PROPN
easat-2730	318	10	prostaglandin	prostaglandin	PROPN
easat-2730	318	11	h2	h2	NOUN
easat-2730	318	12	pgi2	pgi2	PROPN
easat-2730	318	13	prostacyclin	prostacyclin	PROPN
easat-2730	318	14	t	t	PROPN
easat-2730	318	15	-	-	PUNCT
easat-2730	318	16	pa	pa	PROPN
easat-2730	318	17	tissue	tissue	NOUN
easat-2730	318	18	plasminogen	plasminogen	NOUN
easat-2730	318	19	activator	activator	NOUN
easat-2730	318	20	vsmc	vsmc	NOUN
easat-2730	318	21	vascular	vascular	VERB
easat-2730	318	22	smooth	smooth	ADJ
easat-2730	318	23	muscle	muscle	NOUN
easat-2730	318	24	cells	cell	NOUN
easat-2730	318	25	3454	3454	NUM
easat-2730	318	26	edelweiss	edelweiss	PROPN
easat-2730	318	27	applied	apply	VERB
easat-2730	318	28	science	science	NOUN
easat-2730	318	29	and	and	CCONJ
easat-2730	318	30	technology	technology	NOUN
easat-2730	318	31	issn	issn	PROPN
easat-2730	318	32	:	:	PUNCT
easat-2730	318	33	2576	2576	NUM
easat-2730	318	34	-	-	SYM
easat-2730	318	35	8484	8484	NUM
easat-2730	318	36	vol	vol	NOUN
easat-2730	318	37	.	.	PROPN
easat-2730	318	38	8	8	NUM
easat-2730	318	39	,	,	PUNCT
easat-2730	318	40	no	no	INTJ
easat-2730	318	41	.	.	NOUN
easat-2730	319	1	6	6	NUM
easat-2730	319	2	:	:	SYM
easat-2730	319	3	3441	3441	NUM
easat-2730	319	4	-	-	SYM
easat-2730	319	5	3456	3456	NUM
easat-2730	319	6	,	,	PUNCT
easat-2730	319	7	2024	2024	NUM
easat-2730	319	8	doi	doi	NOUN
easat-2730	319	9	:	:	PUNCT
easat-2730	319	10	10.55214/25768484.v8i6.2730	10.55214/25768484.v8i6.2730	NUM
easat-2730	319	11	©	©	ADP
easat-2730	319	12	2024	2024	NUM
easat-2730	319	13	by	by	ADP
easat-2730	319	14	the	the	DET
easat-2730	319	15	authors	author	NOUN
easat-2730	319	16	;	;	PUNCT
easat-2730	319	17	licensee	licensee	PROPN
easat-2730	319	18	learning	learning	NOUN
easat-2730	319	19	gate	gate	PROPN
easat-2730	319	20	so2	so2	PROPN
easat-2730	319	21	superoxide	superoxide	PROPN
easat-2730	319	22	upa	upa	ADJ
easat-2730	319	23	urokinase	urokinase	NOUN
easat-2730	319	24	plasminogen	plasminogen	NOUN
easat-2730	319	25	activator	activator	NOUN
easat-2730	319	26	epcr	epcr	ADJ
easat-2730	319	27	endothelial	endothelial	NOUN
easat-2730	319	28	protein	protein	NOUN
easat-2730	319	29	c	c	NOUN
easat-2730	319	30	receptor	receptor	NOUN
easat-2730	319	31	th	th	X
easat-2730	319	32	t	t	PROPN
easat-2730	319	33	-	-	PUNCT
easat-2730	319	34	helper	helper	NOUN
easat-2730	319	35	no	no	DET
easat-2730	319	36	nitric	nitric	ADJ
easat-2730	319	37	oxide	oxide	NOUN
easat-2730	319	38	,	,	PUNCT
easat-2730	319	39	ikk	ikk	PROPN
easat-2730	319	40	inhibitor	inhibitor	NOUN
easat-2730	319	41	of	of	ADP
easat-2730	319	42	kkinase	kkinase	PROPN
easat-2730	319	43	pkr	pkr	PROPN
easat-2730	319	44	protein	protein	NOUN
easat-2730	319	45	kinase	kinase	PROPN
easat-2730	319	46	-	-	PUNCT
easat-2730	319	47	r	r	NOUN
easat-2730	319	48	crp	crp	PROPN
easat-2730	319	49	c	c	NOUN
easat-2730	319	50	-	-	ADJ
easat-2730	319	51	reactive	reactive	ADJ
easat-2730	319	52	protein	protein	NOUN
easat-2730	319	53	hgf	hgf	NOUN
easat-2730	319	54	hepatocyte	hepatocyte	NOUN
easat-2730	319	55	growth	growth	NOUN
easat-2730	319	56	factor	factor	NOUN
easat-2730	319	57	igf-1	igf-1	NOUN
easat-2730	319	58	insulin	insulin	NOUN
easat-2730	319	59	-	-	PUNCT
easat-2730	319	60	like	like	ADJ
easat-2730	319	61	growth	growth	NOUN
easat-2730	319	62	factor-1	factor-1	PROPN
easat-2730	319	63	mmp2	mmp2	ADJ
easat-2730	319	64	matrix	matrix	NOUN
easat-2730	319	65	metalloproteinase-2	metalloproteinase-2	PRON
easat-2730	319	66	tafi	tafi	VERB
easat-2730	319	67	thrombin	thrombin	NOUN
easat-2730	319	68	-	-	PUNCT
easat-2730	319	69	activatable	activatable	ADJ
easat-2730	319	70	fibrinolytic	fibrinolytic	ADJ
easat-2730	319	71	inhibitor	inhibitor	NOUN
easat-2730	319	72	tfpi	tfpi	VERB
easat-2730	319	73	tissue	tissue	NOUN
easat-2730	319	74	factor	factor	NOUN
easat-2730	319	75	pathway	pathway	NOUN
easat-2730	319	76	inhibitor	inhibitor	NOUN
easat-2730	319	77	cams	cam	NOUN
easat-2730	319	78	cells	cell	NOUN
easat-2730	319	79	adhesion	adhesion	NOUN
easat-2730	319	80	molecules	molecule	NOUN
easat-2730	319	81	edhf	edhf	VERB
easat-2730	319	82	endothelium	endothelium	NOUN
easat-2730	319	83	-	-	PUNCT
easat-2730	319	84	derived	derive	VERB
easat-2730	319	85	hyperbolizing	hyperbolize	VERB
easat-2730	319	86	factor	factor	NOUN
easat-2730	319	87	egf	egf	NOUN
easat-2730	319	88	epidermal	epidermal	ADJ
easat-2730	319	89	growth	growth	NOUN
easat-2730	319	90	factor	factor	NOUN
easat-2730	319	91	hspg	hspg	PROPN
easat-2730	319	92	heparan	heparan	ADJ
easat-2730	319	93	sulfate	sulfate	NOUN
easat-2730	319	94	proteoglycans	proteoglycan	NOUN
easat-2730	319	95	paf	paf	NOUN
easat-2730	319	96	platelet	platelet	NOUN
easat-2730	319	97	-	-	PUNCT
easat-2730	319	98	activating	activate	VERB
easat-2730	319	99	factor	factor	NOUN
easat-2730	319	100	pai-1	pai-1	CCONJ
easat-2730	319	101	plasminogen	plasminogen	NOUN
easat-2730	319	102	activator	activator	NOUN
easat-2730	319	103	inhibitor-1	inhibitor-1	NUM
easat-2730	319	104	pdgf	pdgf	ADJ
easat-2730	319	105	platelet	platelet	NOUN
easat-2730	319	106	-	-	PUNCT
easat-2730	319	107	derived	derive	VERB
easat-2730	319	108	growth	growth	NOUN
easat-2730	319	109	factor	factor	NOUN
easat-2730	319	110	tgf	tgf	PROPN
easat-2730	319	111	-	-	PUNCT
easat-2730	319	112	β	β	X
easat-2730	319	113	transforming	transform	VERB
easat-2730	319	114	growth	growth	NOUN
easat-2730	319	115	factor	factor	NOUN
easat-2730	319	116	-	-	PUNCT
easat-2730	319	117	β	β	X
easat-2730	319	118	txa2	txa2	PROPN
easat-2730	319	119	thromboxane	thromboxane	NOUN
easat-2730	319	120	a2	a2	PROPN
easat-2730	319	121	,	,	PUNCT
easat-2730	319	122	vwf	vwf	NOUN
easat-2730	319	123	vonwillebrand	vonwillebrand	NOUN
easat-2730	319	124	factor	factor	NOUN
easat-2730	319	125	h2o2	h2o2	NOUN
easat-2730	319	126	hydrogen	hydrogen	NOUN
easat-2730	319	127	peroxide	peroxide	NOUN
easat-2730	319	128	tm	tm	PROPN
easat-2730	319	129	thrombomodulin	thrombomodulin	PROPN
easat-2730	319	130	,	,	PUNCT
easat-2730	319	131	α2	α2	PROPN
easat-2730	319	132	-	-	PUNCT
easat-2730	319	133	ap	ap	PROPN
easat-2730	319	134	α2	α2	NOUN
easat-2730	319	135	-	-	PUNCT
easat-2730	319	136	antiplasmin	antiplasmin	VERB
easat-2730	319	137	copyright	copyright	NOUN
easat-2730	319	138	:	:	PUNCT
easat-2730	319	139	©	©	PROPN
easat-2730	319	140	2024	2024	NUM
easat-2730	319	141	by	by	ADP
easat-2730	319	142	the	the	DET
easat-2730	319	143	authors	author	NOUN
easat-2730	319	144	.	.	PUNCT
easat-2730	320	1	this	this	DET
easat-2730	320	2	article	article	NOUN
easat-2730	320	3	is	be	AUX
easat-2730	320	4	an	an	DET
easat-2730	320	5	open	open	ADJ
easat-2730	320	6	access	access	NOUN
easat-2730	320	7	article	article	NOUN
easat-2730	320	8	distributed	distribute	VERB
easat-2730	320	9	under	under	ADP
easat-2730	320	10	the	the	DET
easat-2730	320	11	terms	term	NOUN
easat-2730	320	12	and	and	CCONJ
easat-2730	320	13	conditions	condition	NOUN
easat-2730	320	14	of	of	ADP
easat-2730	320	15	the	the	DET
easat-2730	320	16	creative	creative	ADJ
easat-2730	320	17	commons	common	NOUN
easat-2730	320	18	attribution	attribution	NOUN
easat-2730	320	19	(	(	PUNCT
easat-2730	320	20	cc	cc	NOUN
easat-2730	320	21	by	by	ADP
easat-2730	320	22	)	)	PUNCT
easat-2730	320	23	license	license	NOUN
easat-2730	320	24	(	(	PUNCT
easat-2730	320	25	https://creativecommons.org/licenses/by/4.0/	https://creativecommons.org/licenses/by/4.0/	PROPN
easat-2730	320	26	)	)	PUNCT
easat-2730	320	27	.	.	PUNCT
easat-2730	321	1	references	reference	NOUN
easat-2730	321	2	[	[	X
easat-2730	321	3	1	1	NUM
easat-2730	321	4	]	]	PUNCT
easat-2730	321	5	.	.	PUNCT
easat-2730	322	1	saltiel	saltiel	PROPN
easat-2730	322	2	,	,	PUNCT
easat-2730	322	3	a.	a.	PROPN
easat-2730	322	4	r.	r.	PROPN
easat-2730	322	5	;	;	PUNCT
easat-2730	322	6	and	and	CCONJ
easat-2730	322	7	olefsky	olefsky	ADJ
easat-2730	322	8	,	,	PUNCT
easat-2730	322	9	j.	j.	PROPN
easat-2730	322	10	m.	m.	PROPN
easat-2730	322	11	inflammatory	inflammatory	ADJ
easat-2730	322	12	mechanisms	mechanism	NOUN
easat-2730	322	13	linking	link	VERB
easat-2730	322	14	obesity	obesity	NOUN
easat-2730	322	15	and	and	CCONJ
easat-2730	322	16	metabolic	metabolic	NOUN
easat-2730	322	17	disease	disease	NOUN
easat-2730	322	18	.	.	PUNCT
easat-2730	323	1	2017;127(1):1–4	2017;127(1):1–4	NUM
easat-2730	323	2	.	.	PUNCT
easat-2730	324	1	[	[	X
easat-2730	324	2	2	2	NUM
easat-2730	324	3	]	]	PUNCT
easat-2730	324	4	.	.	PUNCT
easat-2730	325	1	badimon	badimon	PROPN
easat-2730	325	2	,	,	PUNCT
easat-2730	325	3	l.	l.	PROPN
easat-2730	325	4	;	;	PUNCT
easat-2730	325	5	and	and	CCONJ
easat-2730	325	6	hernandez	hernandez	PROPN
easat-2730	325	7	-	-	PUNCT
easat-2730	325	8	vera	vera	PROPN
easat-2730	325	9	,	,	PUNCT
easat-2730	325	10	r.	r.	PROPN
easat-2730	325	11	v.	v.	PROPN
easat-2730	325	12	g.	g.	PROPN
easat-2730	325	13	atherothrombotic	atherothrombotic	PROPN
easat-2730	325	14	risk	risk	NOUN
easat-2730	325	15	in	in	ADP
easat-2730	325	16	obesity	obesity	NOUN
easat-2730	325	17	.	.	PUNCT
easat-2730	326	1	hamostaseologie	hamostaseologie	PROPN
easat-2730	326	2	.	.	PUNCT
easat-2730	327	1	2013;33:259–68	2013;33:259–68	X
easat-2730	327	2	.	.	PUNCT
easat-2730	328	1	[	[	X
easat-2730	328	2	3	3	NUM
easat-2730	328	3	]	]	PUNCT
easat-2730	328	4	.	.	PUNCT
easat-2730	329	1	kwaifa	kwaifa	PROPN
easat-2730	329	2	,	,	PUNCT
easat-2730	329	3	i.	i.	PROPN
easat-2730	329	4	k.	k.	PROPN
easat-2730	329	5	;	;	PUNCT
easat-2730	329	6	bahari	bahari	PROPN
easat-2730	329	7	,	,	PUNCT
easat-2730	329	8	h.	h.	PROPN
easat-2730	329	9	;	;	PUNCT
easat-2730	329	10	yong	yong	PROPN
easat-2730	329	11	,	,	PUNCT
easat-2730	329	12	y.	y.	PROPN
easat-2730	329	13	k.	k.	PROPN
easat-2730	329	14	;	;	PUNCT
easat-2730	329	15	and	and	CCONJ
easat-2730	329	16	noor	noor	PROPN
easat-2730	329	17	,	,	PUNCT
easat-2730	329	18	s.	s.	PROPN
easat-2730	329	19	endothelial	endothelial	ADJ
easat-2730	329	20	dysfunction	dysfunction	NOUN
easat-2730	329	21	in	in	ADP
easat-2730	329	22	obesity	obesity	NOUN
easat-2730	329	23	-	-	PUNCT
easat-2730	329	24	induced	induce	VERB
easat-2730	329	25	inflammation	inflammation	NOUN
easat-2730	329	26	 	 	SPACE
easat-2730	329	27	:	:	PUNCT
easat-2730	329	28	molecular	molecular	ADJ
easat-2730	329	29	mechanisms	mechanism	NOUN
easat-2730	329	30	and	and	CCONJ
easat-2730	329	31	clinical	clinical	ADJ
easat-2730	329	32	implications	implication	NOUN
easat-2730	329	33	.	.	PUNCT
easat-2730	330	1	biomolecules	biomolecule	NOUN
easat-2730	330	2	.	.	PUNCT
easat-2730	331	1	2020;10(291	2020;10(291	NUM
easat-2730	331	2	)	)	PUNCT
easat-2730	331	3	.	.	PUNCT
easat-2730	332	1	[	[	X
easat-2730	332	2	4	4	NUM
easat-2730	332	3	]	]	PUNCT
easat-2730	332	4	.	.	PUNCT
easat-2730	332	5	donato	donato	PROPN
easat-2730	332	6	,	,	PUNCT
easat-2730	332	7	a.	a.	PROPN
easat-2730	332	8	j.	j.	PROPN
easat-2730	332	9	;	;	PUNCT
easat-2730	332	10	machin	machin	PROPN
easat-2730	332	11	,	,	PUNCT
easat-2730	332	12	d.	d.	PROPN
easat-2730	332	13	r.	r.	PROPN
easat-2730	332	14	;	;	PUNCT
easat-2730	332	15	and	and	CCONJ
easat-2730	332	16	lesniewski	lesniewski	PROPN
easat-2730	332	17	,	,	PUNCT
easat-2730	332	18	l	l	NOUN
easat-2730	332	19	;	;	PUNCT
easat-2730	332	20	a.	a.	NOUN
easat-2730	332	21	mechanisms	mechanism	NOUN
easat-2730	332	22	of	of	ADP
easat-2730	332	23	dysfunction	dysfunction	NOUN
easat-2730	332	24	in	in	ADP
easat-2730	332	25	the	the	DET
easat-2730	332	26	aging	age	VERB
easat-2730	332	27	vasculature	vasculature	NOUN
easat-2730	332	28	and	and	CCONJ
easat-2730	332	29	role	role	NOUN
easat-2730	332	30	in	in	ADP
easat-2730	332	31	age	age	NOUN
easat-2730	332	32	-	-	PUNCT
easat-2730	332	33	related	relate	VERB
easat-2730	332	34	disease	disease	NOUN
easat-2730	332	35	.	.	PUNCT
easat-2730	333	1	circ	circ	PROPN
easat-2730	333	2	res	re	NOUN
easat-2730	333	3	.	.	PUNCT
easat-2730	334	1	2018;123(7):825–48	2018;123(7):825–48	NUM
easat-2730	334	2	.	.	PUNCT
easat-2730	335	1	[	[	X
easat-2730	335	2	5	5	NUM
easat-2730	335	3	]	]	PUNCT
easat-2730	335	4	.	.	PUNCT
easat-2730	336	1	mussbacher	mussbacher	NOUN
easat-2730	336	2	,	,	PUNCT
easat-2730	336	3	m.	m.	NOUN
easat-2730	336	4	;	;	PUNCT
easat-2730	336	5	salzmann	salzmann	PROPN
easat-2730	336	6	,	,	PUNCT
easat-2730	336	7	m.	m.	NOUN
easat-2730	336	8	;	;	PUNCT
easat-2730	336	9	brostjan	brostjan	NOUN
easat-2730	336	10	,	,	PUNCT
easat-2730	336	11	c.	c.	NOUN
easat-2730	336	12	;	;	PUNCT
easat-2730	336	13	hoesel	hoesel	VERB
easat-2730	336	14	,	,	PUNCT
easat-2730	336	15	b.	b.	PROPN
easat-2730	336	16	;	;	PUNCT
easat-2730	336	17	schoergenhofer	schoergenhofer	PROPN
easat-2730	336	18	,	,	PUNCT
easat-2730	336	19	c.	c.	NOUN
easat-2730	336	20	;	;	PUNCT
easat-2730	336	21	datler	datler	PROPN
easat-2730	336	22	,	,	PUNCT
easat-2730	336	23	h.	h.	PROPN
easat-2730	336	24	;	;	PUNCT
easat-2730	336	25	hohensinner	hohensinner	ADV
easat-2730	336	26	,	,	PUNCT
easat-2730	336	27	p.	p.	NOUN
easat-2730	336	28	;	;	PUNCT
easat-2730	336	29	basílio	basílio	PROPN
easat-2730	336	30	,	,	PUNCT
easat-2730	336	31	j.	j.	PROPN
easat-2730	336	32	;	;	PUNCT
easat-2730	336	33	petzelbauer	petzelbauer	NOUN
easat-2730	336	34	,	,	PUNCT
easat-2730	336	35	p.	p.	NOUN
easat-2730	336	36	;	;	PUNCT
easat-2730	336	37	assinger	assing	ADJ
easat-2730	336	38	a.	a.	NOUN
easat-2730	336	39	et	et	PROPN
easat-2730	336	40	al	al	PROPN
easat-2730	336	41	.	.	PROPN
easat-2730	336	42	cell	cell	NOUN
easat-2730	336	43	type	type	NOUN
easat-2730	336	44	-	-	PUNCT
easat-2730	336	45	specific	specific	ADJ
easat-2730	336	46	roles	role	NOUN
easat-2730	336	47	of	of	ADP
easat-2730	336	48	nf	nf	NOUN
easat-2730	336	49	-	-	PUNCT
easat-2730	336	50	kb	kb	ADJ
easat-2730	336	51	linking	link	VERB
easat-2730	336	52	inflammation	inflammation	NOUN
easat-2730	336	53	and	and	CCONJ
easat-2730	336	54	thrombosis	thrombosis	NOUN
easat-2730	336	55	.	.	PUNCT
easat-2730	337	1	front	front	ADJ
easat-2730	337	2	immunol	immunol	NOUN
easat-2730	337	3	.	.	PUNCT
easat-2730	338	1	2019;10	2019;10	NOUN
easat-2730	338	2	.	.	PUNCT
easat-2730	339	1	[	[	X
easat-2730	339	2	6	6	NUM
easat-2730	339	3	]	]	PUNCT
easat-2730	339	4	.	.	PUNCT
easat-2730	340	1	cristina	cristina	PROPN
easat-2730	340	2	,	,	PUNCT
easat-2730	340	3	m.	m.	NOUN
easat-2730	340	4	;	;	PUNCT
easat-2730	340	5	sena	sena	PROPN
easat-2730	340	6	,	,	PUNCT
easat-2730	340	7	c.	c.	PROPN
easat-2730	340	8	m.	m.	NOUN
easat-2730	340	9	;	;	PUNCT
easat-2730	340	10	fernanda	fernanda	PROPN
easat-2730	340	11	,	,	PUNCT
easat-2730	340	12	c.	c.	PROPN
easat-2730	340	13	;	;	PUNCT
easat-2730	340	14	and	and	CCONJ
easat-2730	340	15	ans	ans	PROPN
easat-2730	340	16	r.	r.	PROPN
easat-2730	340	17	m.	m.	PROPN
easat-2730	340	18	s.	s.	PROPN
easat-2730	341	1	endothelial	endothelial	ADJ
easat-2730	341	2	dysfunction	dysfunction	NOUN
easat-2730	341	3	in	in	ADP
easat-2730	341	4	type	type	NOUN
easat-2730	341	5	2	2	NUM
easat-2730	341	6	diabetes	diabetes	NOUN
easat-2730	341	7	:	:	PUNCT
easat-2730	341	8	targeting	target	VERB
easat-2730	341	9	inflammation	inflammation	NOUN
easat-2730	341	10	.	.	PUNCT
easat-2730	342	1	we	we	PRON
easat-2730	342	2	are	be	AUX
easat-2730	342	3	intechopen	intechopen	ADJ
easat-2730	342	4	,	,	PUNCT
easat-2730	342	5	world	world	NOUN
easat-2730	342	6	’	'	PUNCT
easat-2730	342	7	s	s	PART
easat-2730	342	8	lead	lead	NOUN
easat-2730	342	9	publ	publ	VERB
easat-2730	342	10	open	open	ADJ
easat-2730	342	11	access	access	NOUN
easat-2730	342	12	books	book	NOUN
easat-2730	342	13	built	build	VERB
easat-2730	342	14	by	by	ADP
easat-2730	342	15	sci	sci	PROPN
easat-2730	342	16	,	,	PUNCT
easat-2730	342	17	sci	sci	PROPN
easat-2730	342	18	top	top	NOUN
easat-2730	342	19	1	1	NUM
easat-2730	342	20	%	%	NOUN
easat-2730	342	21	2018	2018	NUM
easat-2730	342	22	http//dx.doi.org/105772	http//dx.doi.org/105772	NOUN
easat-2730	342	23	/	/	SYM
easat-2730	342	24	intechopen76994	intechopen76994	PROPN
easat-2730	342	25	.	.	PUNCT
easat-2730	343	1	2018	2018	NUM
easat-2730	343	2	;	;	PUNCT
easat-2730	344	1	[	[	X
easat-2730	344	2	7	7	NUM
easat-2730	344	3	]	]	PUNCT
easat-2730	344	4	.	.	PUNCT
easat-2730	344	5	vilahur	vilahur	PROPN
easat-2730	344	6	,	,	PUNCT
easat-2730	344	7	g.	g.	PROPN
easat-2730	344	8	;	;	PUNCT
easat-2730	344	9	ben	ben	PROPN
easat-2730	344	10	-	-	PUNCT
easat-2730	344	11	aicha	aicha	PROPN
easat-2730	344	12	,	,	PUNCT
easat-2730	344	13	s.	s.	PROPN
easat-2730	344	14	;	;	PUNCT
easat-2730	344	15	and	and	CCONJ
easat-2730	344	16	badimon	badimon	NOUN
easat-2730	344	17	,	,	PUNCT
easat-2730	344	18	l.	l.	PROPN
easat-2730	344	19	new	new	ADJ
easat-2730	344	20	insights	insight	NOUN
easat-2730	344	21	into	into	ADP
easat-2730	344	22	the	the	DET
easat-2730	344	23	role	role	NOUN
easat-2730	344	24	of	of	ADP
easat-2730	344	25	adipose	adipose	ADJ
easat-2730	344	26	tissue	tissue	NOUN
easat-2730	344	27	in	in	ADP
easat-2730	344	28	thrombosis	thrombosis	NOUN
easat-2730	344	29	.	.	PUNCT
easat-2730	345	1	2017;1046–54	2017;1046–54	X
easat-2730	345	2	.	.	PUNCT
easat-2730	346	1	[	[	X
easat-2730	346	2	8	8	NUM
easat-2730	346	3	]	]	PUNCT
easat-2730	346	4	.	.	PUNCT
easat-2730	347	1	tousoulis	tousoulis	PROPN
easat-2730	347	2	,	,	PUNCT
easat-2730	347	3	d.	d.	PROPN
easat-2730	347	4	;	;	PUNCT
easat-2730	347	5	kampoli	kampoli	PROPN
easat-2730	347	6	,	,	PUNCT
easat-2730	347	7	a	a	DET
easat-2730	347	8	-	-	PUNCT
easat-2730	347	9	m.	m.	NOUN
easat-2730	347	10	;	;	PUNCT
easat-2730	347	11	tentolouris	tentolouris	PROPN
easat-2730	347	12	,	,	PUNCT
easat-2730	347	13	n.	n.	NOUN
easat-2730	347	14	;	;	PUNCT
easat-2730	347	15	papageorgiou	papageorgiou	NOUN
easat-2730	347	16	,	,	PUNCT
easat-2730	347	17	c.	c.	PROPN
easat-2730	347	18	;	;	PUNCT
easat-2730	347	19	and	and	CCONJ
easat-2730	347	20	stefanadis	stefanadis	PROPN
easat-2730	347	21	,	,	PUNCT
easat-2730	347	22	c.	c.	NOUN
easat-2730	347	23	the	the	DET
easat-2730	347	24	role	role	NOUN
easat-2730	347	25	of	of	ADP
easat-2730	347	26	nitric	nitric	ADJ
easat-2730	347	27	oxide	oxide	NOUN
easat-2730	347	28	on	on	ADP
easat-2730	347	29	endothelial	endothelial	ADJ
easat-2730	347	30	function	function	NOUN
easat-2730	347	31	.	.	PUNCT
easat-2730	348	1	curr	curr	PROPN
easat-2730	348	2	vasc	vasc	PROPN
easat-2730	348	3	pharmacol	pharmacol	PROPN
easat-2730	348	4	.	.	PUNCT
easat-2730	349	1	2011;10(1):4–18	2011;10(1):4–18	NUM
easat-2730	349	2	.	.	PUNCT
easat-2730	350	1	[	[	X
easat-2730	350	2	9	9	NUM
easat-2730	350	3	]	]	PUNCT
easat-2730	350	4	.	.	PUNCT
easat-2730	351	1	forte	forte	PROPN
easat-2730	351	2	,	,	PUNCT
easat-2730	351	3	m.	m.	NOUN
easat-2730	351	4	;	;	PUNCT
easat-2730	351	5	conti	conti	X
easat-2730	351	6	,	,	PUNCT
easat-2730	351	7	v.	v.	PROPN
easat-2730	351	8	;	;	PUNCT
easat-2730	351	9	damato	damato	PROPN
easat-2730	351	10	,	,	PUNCT
easat-2730	351	11	a.	a.	NOUN
easat-2730	351	12	;	;	PUNCT
easat-2730	351	13	ambrosio	ambrosio	NOUN
easat-2730	351	14	,	,	PUNCT
easat-2730	351	15	m.	m.	NOUN
easat-2730	351	16	;	;	PUNCT
easat-2730	351	17	puca	puca	PROPN
easat-2730	351	18	,	,	PUNCT
easat-2730	351	19	a.	a.	NOUN
easat-2730	351	20	a.	a.	PROPN
easat-2730	351	21	;	;	PUNCT
easat-2730	351	22	sciarretta	sciarretta	PROPN
easat-2730	351	23	,	,	PUNCT
easat-2730	351	24	s	s	PROPN
easat-2730	351	25	,	,	PUNCT
easat-2730	351	26	et	et	PROPN
easat-2730	351	27	al	al	PROPN
easat-2730	351	28	.	.	PUNCT
easat-2730	352	1	targeting	target	VERB
easat-2730	352	2	nitric	nitric	ADJ
easat-2730	352	3	oxide	oxide	NOUN
easat-2730	352	4	with	with	ADP
easat-2730	352	5	natural	natural	ADJ
easat-2730	352	6	derived	derive	VERB
easat-2730	352	7	compounds	compound	NOUN
easat-2730	352	8	as	as	ADP
easat-2730	352	9	a	a	DET
easat-2730	352	10	therapeutic	therapeutic	ADJ
easat-2730	352	11	strategy	strategy	NOUN
easat-2730	352	12	in	in	ADP
easat-2730	352	13	vascular	vascular	ADJ
easat-2730	352	14	diseases	disease	NOUN
easat-2730	352	15	.	.	PUNCT
easat-2730	353	1	2016;2016	2016;2016	NUM
easat-2730	353	2	.	.	PUNCT
easat-2730	354	1	[	[	X
easat-2730	354	2	10	10	NUM
easat-2730	354	3	]	]	PUNCT
easat-2730	354	4	.	.	PUNCT
easat-2730	355	1	wang	wang	PROPN
easat-2730	355	2	,	,	PUNCT
easat-2730	355	3	m.	m.	NOUN
easat-2730	355	4	;	;	PUNCT
easat-2730	355	5	hao	hao	PROPN
easat-2730	355	6	,	,	PUNCT
easat-2730	355	7	h.	h.	PROPN
easat-2730	355	8	;	;	PUNCT
easat-2730	355	9	leeper	leeper	PROPN
easat-2730	355	10	,	,	PUNCT
easat-2730	355	11	n.	n.	PROPN
easat-2730	355	12	j.	j.	PROPN
easat-2730	355	13	;	;	PUNCT
easat-2730	355	14	and	and	CCONJ
easat-2730	355	15	zhu	zhu	PROPN
easat-2730	355	16	,	,	PUNCT
easat-2730	355	17	l.	l.	PROPN
easat-2730	355	18	thrombotic	thrombotic	ADJ
easat-2730	355	19	regulation	regulation	NOUN
easat-2730	355	20	from	from	ADP
easat-2730	355	21	the	the	DET
easat-2730	355	22	endothelial	endothelial	ADJ
easat-2730	355	23	cell	cell	NOUN
easat-2730	355	24	perspectives	perspective	NOUN
easat-2730	355	25	.	.	PUNCT
easat-2730	356	1	arterioscler	arterioscler	PROPN
easat-2730	356	2	thromb	thromb	PROPN
easat-2730	356	3	vasc	vasc	PROPN
easat-2730	356	4	biol	biol	PROPN
easat-2730	356	5	.	.	PUNCT
easat-2730	357	1	2018;38(6):e90–5	2018;38(6):e90–5	NUM
easat-2730	357	2	.	.	PUNCT
easat-2730	358	1	[	[	X
easat-2730	358	2	11	11	NUM
easat-2730	358	3	]	]	PUNCT
easat-2730	358	4	.	.	PUNCT
easat-2730	359	1	swieringa	swieringa	PROPN
easat-2730	359	2	,	,	PUNCT
easat-2730	359	3	f.	f.	PROPN
easat-2730	359	4	;	;	PUNCT
easat-2730	359	5	baaten	baaten	VERB
easat-2730	359	6	,	,	PUNCT
easat-2730	359	7	c.	c.	PROPN
easat-2730	359	8	c.	c.	PROPN
easat-2730	359	9	;	;	PUNCT
easat-2730	359	10	verdoold	verdoold	PROPN
easat-2730	359	11	,	,	PUNCT
easat-2730	359	12	r.	r.	PROPN
easat-2730	359	13	;	;	PUNCT
easat-2730	359	14	mastenbroek	mastenbroek	NOUN
easat-2730	359	15	,	,	PUNCT
easat-2730	359	16	t.	t.	PROPN
easat-2730	359	17	g.	g.	PROPN
easat-2730	359	18	;	;	PUNCT
easat-2730	359	19	rijnveld	rijnveld	VERB
easat-2730	359	20	,	,	PUNCT
easat-2730	359	21	n.	n.	NOUN
easat-2730	359	22	;	;	PUNCT
easat-2730	360	1	van	van	PROPN
easat-2730	360	2	der	der	PROPN
easat-2730	360	3	laan	laan	PROPN
easat-2730	360	4	,	,	PUNCT
easat-2730	360	5	k.	k.	PROPN
easat-2730	360	6	o.	o.	PROPN
easat-2730	360	7	;	;	PUNCT
easat-2730	360	8	breel	breel	PROPN
easat-2730	360	9	,	,	PUNCT
easat-2730	360	10	e.	e.	PROPN
easat-2730	360	11	j.	j.	PROPN
easat-2730	360	12	;	;	PUNCT
easat-2730	360	13	collins	collins	PROPN
easat-2730	360	14	,	,	PUNCT
easat-2730	360	15	p.	p.	PROPN
easat-2730	360	16	w.	w.	PROPN
easat-2730	360	17	;	;	PUNCT
easat-2730	360	18	lancé	lancé	PROPN
easat-2730	360	19	,	,	PUNCT
easat-2730	360	20	m.	m.	PROPN
easat-2730	360	21	d.	d.	PROPN
easat-2730	360	22	;	;	PUNCT
easat-2730	360	23	henskens	hensken	NOUN
easat-2730	360	24	,	,	PUNCT
easat-2730	360	25	y.	y.	NOUN
easat-2730	360	26	m.	m.	NOUN
easat-2730	360	27	;	;	PUNCT
easat-2730	360	28	cosemans	coseman	NOUN
easat-2730	360	29	,	,	PUNCT
easat-2730	360	30	j.	j.	PROPN
easat-2730	360	31	m.	m.	PROPN
easat-2730	360	32	;	;	PUNCT
easat-2730	360	33	heemskerk	heemskerk	NOUN
easat-2730	360	34	,	,	PUNCT
easat-2730	360	35	j.	j.	PROPN
easat-2730	360	36	w.	w.	PROPN
easat-2730	360	37	;	;	PUNCT
easat-2730	360	38	and	and	CCONJ
easat-2730	360	39	van	van	PROPN
easat-2730	360	40	der	der	PROPN
easat-2730	360	41	,	,	PUNCT
easat-2730	360	42	m.	m.	NOUN
easat-2730	360	43	p.	p.	NOUN
easat-2730	360	44	platelet	platelet	NOUN
easat-2730	360	45	control	control	NOUN
easat-2730	360	46	of	of	ADP
easat-2730	360	47	fibrin	fibrin	NOUN
easat-2730	360	48	distribution	distribution	NOUN
easat-2730	360	49	and	and	CCONJ
easat-2730	360	50	microelasticity	microelasticity	NOUN
easat-2730	360	51	in	in	ADP
easat-2730	360	52	thrombus	thrombus	ADJ
easat-2730	360	53	formation	formation	NOUN
easat-2730	360	54	under	under	ADP
easat-2730	360	55	flow	flow	NOUN
easat-2730	360	56	.	.	PUNCT
easat-2730	361	1	arter	arter	NOUN
easat-2730	361	2	thromb	thromb	PROPN
easat-2730	361	3	vasc	vasc	PROPN
easat-2730	361	4	biol	biol	PROPN
easat-2730	361	5	.	.	PUNCT
easat-2730	362	1	2016;36:699	2016;36:699	X
easat-2730	362	2	.	.	PUNCT
easat-2730	362	3	doi	doi	NOUN
easat-2730	362	4	:	:	PUNCT
easat-2730	362	5	10.1161	10.1161	NUM
easat-2730	362	6	/	/	SYM
easat-2730	362	7	atvbaha.115.306537	atvbaha.115.306537	NOUN
easat-2730	362	8	.	.	PUNCT
easat-2730	363	1	[	[	X
easat-2730	363	2	12	12	NUM
easat-2730	363	3	]	]	PUNCT
easat-2730	363	4	.	.	PUNCT
easat-2730	364	1	katakami	katakami	NOUN
easat-2730	364	2	,	,	PUNCT
easat-2730	364	3	n.	n.	NOUN
easat-2730	364	4	mechanism	mechanism	NOUN
easat-2730	364	5	of	of	ADP
easat-2730	364	6	development	development	NOUN
easat-2730	364	7	of	of	ADP
easat-2730	364	8	atherosclerosis	atherosclerosis	NOUN
easat-2730	364	9	and	and	CCONJ
easat-2730	364	10	cardiovascular	cardiovascular	ADJ
easat-2730	364	11	disease	disease	NOUN
easat-2730	364	12	in	in	ADP
easat-2730	364	13	diabetes	diabetes	NOUN
easat-2730	364	14	mellitus	mellitus	NOUN
easat-2730	364	15	.	.	PUNCT
easat-2730	365	1	https://creativecommons.org/licenses/by/4.0/	https://creativecommons.org/licenses/by/4.0/	PROPN
easat-2730	365	2	3455	3455	NUM
easat-2730	365	3	edelweiss	edelweiss	PROPN
easat-2730	365	4	applied	apply	VERB
easat-2730	365	5	science	science	NOUN
easat-2730	365	6	and	and	CCONJ
easat-2730	365	7	technology	technology	NOUN
easat-2730	365	8	issn	issn	PROPN
easat-2730	365	9	:	:	PUNCT
easat-2730	365	10	2576	2576	NUM
easat-2730	365	11	-	-	SYM
easat-2730	365	12	8484	8484	NUM
easat-2730	365	13	vol	vol	NOUN
easat-2730	365	14	.	.	PROPN
easat-2730	365	15	8	8	NUM
easat-2730	365	16	,	,	PUNCT
easat-2730	365	17	no	no	INTJ
easat-2730	365	18	.	.	NOUN
easat-2730	366	1	6	6	NUM
easat-2730	366	2	:	:	SYM
easat-2730	366	3	3441	3441	NUM
easat-2730	366	4	-	-	SYM
easat-2730	366	5	3456	3456	NUM
easat-2730	366	6	,	,	PUNCT
easat-2730	366	7	2024	2024	NUM
easat-2730	366	8	doi	doi	NOUN
easat-2730	366	9	:	:	PUNCT
easat-2730	366	10	10.55214/25768484.v8i6.2730	10.55214/25768484.v8i6.2730	NUM
easat-2730	366	11	©	©	ADP
easat-2730	366	12	2024	2024	NUM
easat-2730	366	13	by	by	ADP
easat-2730	366	14	the	the	DET
easat-2730	366	15	authors	author	NOUN
easat-2730	366	16	;	;	PUNCT
easat-2730	366	17	licensee	licensee	PROPN
easat-2730	366	18	learning	learn	VERB
easat-2730	366	19	gate	gate	NOUN
easat-2730	366	20	2018;27–39	2018;27–39	PROPN
easat-2730	366	21	.	.	PUNCT
easat-2730	367	1	[	[	X
easat-2730	367	2	13	13	NUM
easat-2730	367	3	]	]	PUNCT
easat-2730	367	4	.	.	PUNCT
easat-2730	367	5	digennaro	digennaro	PROPN
easat-2730	367	6	,	,	PUNCT
easat-2730	367	7	f.	f.	PROPN
easat-2730	367	8	;	;	PUNCT
easat-2730	367	9	and	and	CCONJ
easat-2730	367	10	dominici	dominici	PROPN
easat-2730	367	11	,	,	PUNCT
easat-2730	367	12	f.	f.	PROPN
easat-2730	367	13	p.	p.	PROPN
easat-2730	367	14	nebivolol	nebivolol	PROPN
easat-2730	367	15	 	 	SPACE
easat-2730	367	16	:	:	PUNCT
easat-2730	367	17	impact	impact	NOUN
easat-2730	367	18	on	on	ADP
easat-2730	367	19	cardiac	cardiac	ADJ
easat-2730	367	20	and	and	CCONJ
easat-2730	367	21	endothelial	endothelial	ADJ
easat-2730	367	22	function	function	NOUN
easat-2730	367	23	and	and	CCONJ
easat-2730	367	24	clinical	clinical	ADJ
easat-2730	367	25	utility	utility	NOUN
easat-2730	367	26	.	.	PUNCT
easat-2730	368	1	2012;(march	2012;(march	NUM
easat-2730	368	2	)	)	PUNCT
easat-2730	368	3	.	.	PUNCT
easat-2730	369	1	[	[	X
easat-2730	369	2	14	14	NUM
easat-2730	369	3	]	]	PUNCT
easat-2730	369	4	.	.	PUNCT
easat-2730	370	1	kopec	kopec	PROPN
easat-2730	370	2	,	,	PUNCT
easat-2730	370	3	a.	a.	PROPN
easat-2730	370	4	k	k	PROPN
easat-2730	370	5	,	,	PUNCT
easat-2730	370	6	;	;	PUNCT
easat-2730	370	7	abrahams	abraham	NOUN
easat-2730	370	8	,	,	PUNCT
easat-2730	370	9	s.	s.	PROPN
easat-2730	370	10	r	r	PROPN
easat-2730	370	11	,	,	PUNCT
easat-2730	370	12	;	;	PUNCT
easat-2730	370	13	thornton	thornton	PROPN
easat-2730	370	14	,	,	PUNCT
easat-2730	370	15	s.	s.	PROPN
easat-2730	370	16	;	;	PUNCT
easat-2730	370	17	palumbo	palumbo	PROPN
easat-2730	370	18	,	,	PUNCT
easat-2730	370	19	j.	j.	PROPN
easat-2730	370	20	s.	s.	PROPN
easat-2730	370	21	;	;	PUNCT
easat-2730	370	22	mullins	mullins	PROPN
easat-2730	370	23	,	,	PUNCT
easat-2730	370	24	e.	e.	PROPN
easat-2730	370	25	s.	s.	PROPN
easat-2730	370	26	;	;	PUNCT
easat-2730	370	27	divanovic	divanovic	ADJ
easat-2730	370	28	,	,	PUNCT
easat-2730	370	29	s	s	X
easat-2730	370	30	,	,	PUNCT
easat-2730	370	31	et	et	PROPN
easat-2730	370	32	al	al	PROPN
easat-2730	370	33	.	.	PROPN
easat-2730	371	1	thrombin	thrombin	PROPN
easat-2730	371	2	promotes	promote	VERB
easat-2730	371	3	diet	diet	NOUN
easat-2730	371	4	-	-	PUNCT
easat-2730	371	5	induced	induce	VERB
easat-2730	371	6	obesity	obesity	NOUN
easat-2730	371	7	through	through	ADP
easat-2730	371	8	fibrin	fibrin	NOUN
easat-2730	371	9	-	-	PUNCT
easat-2730	371	10	driven	drive	VERB
easat-2730	371	11	inflammation	inflammation	NOUN
easat-2730	371	12	.	.	PUNCT
easat-2730	372	1	j	j	PROPN
easat-2730	372	2	clin	clin	PROPN
easat-2730	372	3	invest	invest	PROPN
easat-2730	372	4	.	.	PUNCT
easat-2730	373	1	2017;127(8):3152–66	2017;127(8):3152–66	X
easat-2730	373	2	.	.	PUNCT
easat-2730	374	1	[	[	X
easat-2730	374	2	15	15	NUM
easat-2730	374	3	]	]	PUNCT
easat-2730	374	4	.	.	PUNCT
easat-2730	374	5	ellulu	ellulu	PROPN
easat-2730	374	6	,	,	PUNCT
easat-2730	374	7	m.	m.	NOUN
easat-2730	374	8	s.	s.	PROPN
easat-2730	374	9	;	;	PUNCT
easat-2730	374	10	patimah	patimah	PROPN
easat-2730	374	11	,	,	PUNCT
easat-2730	374	12	i.	i.	NOUN
easat-2730	374	13	;	;	PUNCT
easat-2730	374	14	khaza	khaza	PROPN
easat-2730	374	15	,	,	PUNCT
easat-2730	374	16	h.	h.	PROPN
easat-2730	374	17	;	;	PUNCT
easat-2730	374	18	rahmat	rahmat	NOUN
easat-2730	374	19	,	,	PUNCT
easat-2730	374	20	a.	a.	NOUN
easat-2730	374	21	;	;	PUNCT
easat-2730	374	22	and	and	CCONJ
easat-2730	374	23	abed	abe	VERB
easat-2730	374	24	,	,	PUNCT
easat-2730	374	25	y.	y.	PROPN
easat-2730	374	26	state	state	NOUN
easat-2730	374	27	of	of	ADP
easat-2730	374	28	the	the	DET
easat-2730	374	29	art	art	NOUN
easat-2730	374	30	paper	paper	NOUN
easat-2730	374	31	obesity	obesity	NOUN
easat-2730	374	32	and	and	CCONJ
easat-2730	374	33	inflammation	inflammation	NOUN
easat-2730	374	34	 	 	SPACE
easat-2730	374	35	:	:	PUNCT
easat-2730	374	36	the	the	DET
easat-2730	374	37	linking	link	VERB
easat-2730	374	38	mechanism	mechanism	NOUN
easat-2730	374	39	and	and	CCONJ
easat-2730	374	40	the	the	DET
easat-2730	374	41	complications	complication	NOUN
easat-2730	374	42	.	.	PUNCT
easat-2730	375	1	2017	2017	NUM
easat-2730	375	2	;	;	PUNCT
easat-2730	376	1	[	[	X
easat-2730	376	2	16	16	NUM
easat-2730	376	3	]	]	PUNCT
easat-2730	376	4	.	.	PUNCT
easat-2730	377	1	wu	wu	PROPN
easat-2730	377	2	,	,	PUNCT
easat-2730	377	3	h.	h.	PROPN
easat-2730	377	4	c.	c.	PROPN
easat-2730	377	5	;	;	PUNCT
easat-2730	377	6	horng	horng	PROPN
easat-2730	377	7	,	,	PUNCT
easat-2730	377	8	c.	c.	PROPN
easat-2730	377	9	t.	t.	PROPN
easat-2730	377	10	;	;	PUNCT
easat-2730	377	11	tsai	tsai	PROPN
easat-2730	377	12	,	,	PUNCT
easat-2730	377	13	s.	s.	PROPN
easat-2730	377	14	c.	c.	PROPN
easat-2730	377	15	;	;	PUNCT
easat-2730	377	16	lee	lee	PROPN
easat-2730	377	17	,	,	PUNCT
easat-2730	377	18	y.	y.	PROPN
easat-2730	377	19	l.	l.	PROPN
easat-2730	377	20	;	;	PUNCT
easat-2730	377	21	hsu	hsu	PROPN
easat-2730	377	22	,	,	PUNCT
easat-2730	377	23	s.	s.	PROPN
easat-2730	377	24	c.	c.	PROPN
easat-2730	377	25	;	;	PUNCT
easat-2730	377	26	tsai	tsai	PROPN
easat-2730	377	27	,	,	PUNCT
easat-2730	377	28	y.	y.	PROPN
easat-2730	377	29	j	j	PROPN
easat-2730	377	30	,	,	PUNCT
easat-2730	377	31	et	et	PROPN
easat-2730	377	32	al	al	PROPN
easat-2730	377	33	.	.	PROPN
easat-2730	377	34	relaxant	relaxant	PROPN
easat-2730	377	35	and	and	CCONJ
easat-2730	377	36	vasoprotective	vasoprotective	ADJ
easat-2730	377	37	effects	effect	NOUN
easat-2730	377	38	of	of	ADP
easat-2730	377	39	ginger	ginger	NOUN
easat-2730	377	40	extracts	extract	NOUN
easat-2730	377	41	on	on	ADP
easat-2730	377	42	porcine	porcine	ADJ
easat-2730	377	43	coronary	coronary	ADJ
easat-2730	377	44	arteries	artery	NOUN
easat-2730	377	45	.	.	PUNCT
easat-2730	378	1	int	int	PROPN
easat-2730	378	2	j	j	PROPN
easat-2730	378	3	mol	mol	ADP
easat-2730	378	4	med	med	PROPN
easat-2730	378	5	.	.	PUNCT
easat-2730	379	1	2018;41(4):2420–8	2018;41(4):2420–8	X
easat-2730	379	2	.	.	PUNCT
easat-2730	380	1	[	[	X
easat-2730	380	2	17	17	NUM
easat-2730	380	3	]	]	PUNCT
easat-2730	380	4	.	.	PUNCT
easat-2730	381	1	dhananjayan	dhananjayan	ADJ
easat-2730	381	2	,	,	PUNCT
easat-2730	381	3	r	r	NOUN
easat-2730	381	4	,	,	PUNCT
easat-2730	381	5	;	;	PUNCT
easat-2730	381	6	koundinya	koundinya	PROPN
easat-2730	381	7	,	,	PUNCT
easat-2730	381	8	k.	k.	PROPN
easat-2730	381	9	s.	s.	PROPN
easat-2730	381	10	s.	s.	PROPN
easat-2730	381	11	;	;	PUNCT
easat-2730	381	12	malati	malati	PROPN
easat-2730	381	13	,	,	PUNCT
easat-2730	381	14	t.	t.	PROPN
easat-2730	381	15	;	;	PUNCT
easat-2730	381	16	and	and	CCONJ
easat-2730	381	17	kutala	kutala	PROPN
easat-2730	381	18	,	,	PUNCT
easat-2730	381	19	v.	v.	PROPN
easat-2730	381	20	k.	k.	PROPN
easat-2730	382	1	endothelial	endothelial	ADJ
easat-2730	382	2	dysfunction	dysfunction	NOUN
easat-2730	382	3	in	in	ADP
easat-2730	382	4	type	type	NOUN
easat-2730	382	5	2	2	NUM
easat-2730	382	6	diabetes	diabetes	NOUN
easat-2730	382	7	mellitus	mellitus	NOUN
easat-2730	382	8	.	.	PUNCT
easat-2730	383	1	indian	indian	PROPN
easat-2730	383	2	j	j	PROPN
easat-2730	383	3	clin	clin	PROPN
easat-2730	383	4	biochem	biochem	PROPN
easat-2730	383	5	.	.	PUNCT
easat-2730	384	1	2016;31(4):372–9	2016;31(4):372–9	NUM
easat-2730	384	2	.	.	PUNCT
easat-2730	385	1	[	[	X
easat-2730	385	2	18	18	NUM
easat-2730	385	3	]	]	PUNCT
easat-2730	385	4	.	.	PUNCT
easat-2730	386	1	van	van	PROPN
easat-2730	386	2	den	den	PROPN
easat-2730	386	3	oever	oever	PROPN
easat-2730	386	4	,	,	PUNCT
easat-2730	386	5	i.	i.	PROPN
easat-2730	386	6	a.	a.	PROPN
easat-2730	386	7	;	;	PUNCT
easat-2730	386	8	raterman	raterman	PROPN
easat-2730	386	9	,	,	PUNCT
easat-2730	386	10	h.	h.	PROPN
easat-2730	386	11	g.	g.	PROPN
easat-2730	386	12	;	;	PUNCT
easat-2730	386	13	and	and	CCONJ
easat-2730	386	14	nurmohamed	nurmohamed	ADJ
easat-2730	386	15	,	,	PUNCT
easat-2730	386	16	m.	m.	NOUN
easat-2730	386	17	t.	t.	PROPN
easat-2730	386	18	s.	s.	PROPN
easat-2730	386	19	s.	s.	PROPN
easat-2730	386	20	endothelial	endothelial	ADJ
easat-2730	386	21	dysfunction	dysfunction	NOUN
easat-2730	386	22	,	,	PUNCT
easat-2730	386	23	inflammation	inflammation	NOUN
easat-2730	386	24	,	,	PUNCT
easat-2730	386	25	and	and	CCONJ
easat-2730	386	26	apoptosis	apoptosis	NOUN
easat-2730	386	27	in	in	ADP
easat-2730	386	28	diabetes	diabetes	NOUN
easat-2730	386	29	mellitus	mellitus	NOUN
easat-2730	386	30	.	.	PUNCT
easat-2730	387	1	mediat	mediat	PROPN
easat-2730	387	2	inflamm	inflamm	PROPN
easat-2730	387	3	.	.	PUNCT
easat-2730	388	1	[	[	X
easat-2730	388	2	19	19	NUM
easat-2730	388	3	]	]	PUNCT
easat-2730	388	4	.	.	PUNCT
easat-2730	389	1	congiu	congiu	PROPN
easat-2730	389	2	,	,	PUNCT
easat-2730	389	3	t.	t.	PROPN
easat-2730	389	4	;	;	PUNCT
easat-2730	389	5	schembri	schembri	PROPN
easat-2730	389	6	,	,	PUNCT
easat-2730	389	7	l.	l.	PROPN
easat-2730	389	8	;	;	PUNCT
easat-2730	389	9	tozzi	tozzi	NOUN
easat-2730	389	10	,	,	PUNCT
easat-2730	389	11	m.	m.	NOUN
easat-2730	389	12	;	;	PUNCT
easat-2730	389	13	guasti	guasti	PROPN
easat-2730	389	14	,	,	PUNCT
easat-2730	389	15	l.	l.	PROPN
easat-2730	389	16	;	;	PUNCT
easat-2730	389	17	maio	maio	PROPN
easat-2730	389	18	,	,	PUNCT
easat-2730	389	19	r.	r.	PROPN
easat-2730	389	20	c.	c.	PROPN
easat-2730	389	21	;	;	PUNCT
easat-2730	389	22	cosentino	cosentino	PROPN
easat-2730	389	23	,	,	PUNCT
easat-2730	389	24	m	m	PROPN
easat-2730	389	25	,	,	PUNCT
easat-2730	389	26	et	et	PROPN
easat-2730	389	27	al	al	PROPN
easat-2730	389	28	.	.	PUNCT
easat-2730	390	1	scanning	scan	VERB
easat-2730	390	2	electron	electron	NOUN
easat-2730	390	3	microscopy	microscopy	NOUN
easat-2730	390	4	examination	examination	NOUN
easat-2730	390	5	of	of	ADP
easat-2730	390	6	endothelium	endothelium	NOUN
easat-2730	390	7	morphology	morphology	NOUN
easat-2730	390	8	in	in	ADP
easat-2730	390	9	human	human	ADJ
easat-2730	390	10	carotid	carotid	NOUN
easat-2730	390	11	plaques	plaque	NOUN
easat-2730	390	12	.	.	PUNCT
easat-2730	391	1	micron	micron	NOUN
easat-2730	392	1	[	[	X
easat-2730	392	2	internet	internet	NOUN
easat-2730	392	3	]	]	PUNCT
easat-2730	392	4	.	.	PUNCT
easat-2730	393	1	2010;41(5):532–6	2010;41(5):532–6	NUM
easat-2730	393	2	.	.	PUNCT
easat-2730	393	3	available	available	ADJ
easat-2730	393	4	from	from	ADP
easat-2730	393	5	:	:	PUNCT
easat-2730	393	6	http://dx.doi.org/10.1016/j.micron.2010.01.006	http://dx.doi.org/10.1016/j.micron.2010.01.006	PROPN
easat-2730	393	7	[	[	X
easat-2730	393	8	20	20	NUM
easat-2730	393	9	]	]	PUNCT
easat-2730	393	10	.	.	PUNCT
easat-2730	394	1	qadir	qadir	PROPN
easat-2730	394	2	,	,	PUNCT
easat-2730	394	3	m.	m.	NOUN
easat-2730	394	4	i.	i.	PROPN
easat-2730	394	5	;	;	PUNCT
easat-2730	394	6	manzoor	manzoor	PROPN
easat-2730	394	7	,	,	PUNCT
easat-2730	394	8	a.	a.	NOUN
easat-2730	394	9	;	;	PUNCT
easat-2730	394	10	and	and	CCONJ
easat-2730	394	11	akash	akash	PROPN
easat-2730	394	12	,	,	PUNCT
easat-2730	394	13	m.	m.	NOUN
easat-2730	394	14	s.	s.	PROPN
easat-2730	394	15	h.	h.	PROPN
easat-2730	395	1	potential	potential	ADJ
easat-2730	395	2	role	role	NOUN
easat-2730	395	3	of	of	ADP
easat-2730	395	4	medicinal	medicinal	ADJ
easat-2730	395	5	plants	plant	NOUN
easat-2730	395	6	for	for	ADP
easat-2730	395	7	anti	anti	ADJ
easat-2730	395	8	-	-	ADJ
easat-2730	395	9	atherosclerosis	atherosclerosis	ADJ
easat-2730	395	10	activity	activity	NOUN
easat-2730	395	11	.	.	PUNCT
easat-2730	396	1	bangladesh	bangladesh	PROPN
easat-2730	396	2	j	j	PROPN
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easat-2730	396	4	.	.	PUNCT
easat-2730	397	1	2018;13(1):59–66	2018;13(1):59–66	X
easat-2730	397	2	.	.	PUNCT
easat-2730	398	1	[	[	X
easat-2730	398	2	21	21	NUM
easat-2730	398	3	]	]	PUNCT
easat-2730	398	4	.	.	PUNCT
easat-2730	398	5	athanasiou	athanasiou	PROPN
easat-2730	398	6	,	,	PUNCT
easat-2730	398	7	l.	l.	PROPN
easat-2730	398	8	s.	s.	PROPN
easat-2730	398	9	;	;	PUNCT
easat-2730	398	10	michalis	michalis	PROPN
easat-2730	398	11	,	,	PUNCT
easat-2730	398	12	l.	l.	PROPN
easat-2730	398	13	k.	k.	PROPN
easat-2730	398	14	;	;	PUNCT
easat-2730	398	15	and	and	CCONJ
easat-2730	398	16	charac-	charac-	X
easat-2730	398	17	,	,	PUNCT
easat-2730	398	18	a.	a.	NOUN
easat-2730	398	19	p.	p.	NOUN
easat-2730	398	20	atherogenesis	atherogenesis	NOUN
easat-2730	398	21	learn	learn	VERB
easat-2730	398	22	more	more	ADJ
easat-2730	398	23	about	about	ADP
easat-2730	398	24	atherogenesis	atherogenesis	ADJ
easat-2730	398	25	introduction	introduction	NOUN
easat-2730	398	26	.	.	PUNCT
easat-2730	399	1	2017	2017	NUM
easat-2730	399	2	;	;	PUNCT
easat-2730	400	1	[	[	X
easat-2730	400	2	22	22	NUM
easat-2730	400	3	]	]	PUNCT
easat-2730	400	4	.	.	PUNCT
easat-2730	401	1	wisniewska	wisniewska	PROPN
easat-2730	401	2	,	,	PUNCT
easat-2730	401	3	a.	a.	NOUN
easat-2730	401	4	;	;	PUNCT
easat-2730	401	5	olszanecki	olszanecki	PROPN
easat-2730	401	6	,	,	PUNCT
easat-2730	401	7	r.	r.	PROPN
easat-2730	401	8	;	;	PUNCT
easat-2730	401	9	toton	toton	NOUN
easat-2730	401	10	´	´	NOUN
easat-2730	401	11	-z˙	-z˙	PUNCT
easat-2730	401	12	uran	uran	PROPN
easat-2730	401	13	´	´	PROPN
easat-2730	401	14	ska	ska	PROPN
easat-2730	401	15	,	,	PUNCT
easat-2730	401	16	j.	j.	PROPN
easat-2730	401	17	;	;	PUNCT
easat-2730	401	18	kus	kus	PROPN
easat-2730	401	19	´	´	PROPN
easat-2730	401	20	,	,	PUNCT
easat-2730	401	21	k.	k.	PROPN
easat-2730	401	22	;	;	PUNCT
easat-2730	401	23	stachowicz	stachowicz	NOUN
easat-2730	401	24	,	,	PUNCT
easat-2730	401	25	a.	a.	NOUN
easat-2730	401	26	;	;	PUNCT
easat-2730	401	27	suski	suski	PROPN
easat-2730	401	28	,	,	PUNCT
easat-2730	401	29	m.	m.	NOUN
easat-2730	401	30	;	;	PUNCT
easat-2730	401	31	ge˛bska	ge˛bska	PROPN
easat-2730	401	32	,	,	PUNCT
easat-2730	401	33	a.	a.	NOUN
easat-2730	401	34	;	;	PUNCT
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easat-2730	401	36	,	,	PUNCT
easat-2730	401	37	m.	m.	NOUN
easat-2730	401	38	;	;	PUNCT
easat-2730	401	39	jawie	jawie	PROPN
easat-2730	401	40	´	´	PROPN
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easat-2730	401	42	,	,	PUNCT
easat-2730	401	43	j.	j.	PROPN
easat-2730	401	44	;	;	PUNCT
easat-2730	401	45	and	and	CCONJ
easat-2730	401	46	korbut	korbut	PROPN
easat-2730	401	47	r.	r.	PROPN
easat-2730	401	48	anti	anti	ADJ
easat-2730	401	49	-	-	ADJ
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easat-2730	401	51	action	action	NOUN
easat-2730	401	52	of	of	ADP
easat-2730	401	53	agmatine	agmatine	NOUN
easat-2730	401	54	in	in	ADP
easat-2730	401	55	apoe	apoe	ADJ
easat-2730	401	56	-	-	PUNCT
easat-2730	401	57	knockout	knockout	NOUN
easat-2730	401	58	mice	mouse	NOUN
easat-2730	401	59	.	.	PUNCT
easat-2730	402	1	int	int	PROPN
easat-2730	402	2	j	j	PROPN
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easat-2730	402	5	.	.	PUNCT
easat-2730	402	6	2017;18(1706	2017;18(1706	NUM
easat-2730	402	7	)	)	PUNCT
easat-2730	402	8	.	.	PUNCT
easat-2730	403	1	[	[	X
easat-2730	403	2	23	23	NUM
easat-2730	403	3	]	]	PUNCT
easat-2730	403	4	.	.	PUNCT
easat-2730	403	5	bentzon	bentzon	PROPN
easat-2730	403	6	,	,	PUNCT
easat-2730	403	7	j.	j.	PROPN
easat-2730	403	8	f.	f.	PROPN
easat-2730	403	9	;	;	PUNCT
easat-2730	403	10	otsuka	otsuka	PROPN
easat-2730	403	11	,	,	PUNCT
easat-2730	403	12	f.	f.	PROPN
easat-2730	403	13	;	;	PUNCT
easat-2730	403	14	virmani	virmani	PROPN
easat-2730	403	15	,	,	PUNCT
easat-2730	403	16	r.	r.	PROPN
easat-2730	403	17	;	;	PUNCT
easat-2730	403	18	and	and	CCONJ
easat-2730	403	19	falk	falk	NOUN
easat-2730	403	20	,	,	PUNCT
easat-2730	403	21	e.	e.	PROPN
easat-2730	403	22	mechanisms	mechanism	NOUN
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easat-2730	403	25	formation	formation	NOUN
easat-2730	403	26	and	and	CCONJ
easat-2730	403	27	rupture	rupture	NOUN
easat-2730	403	28	.	.	PUNCT
easat-2730	404	1	2014;1852–66	2014;1852–66	X
easat-2730	404	2	.	.	PUNCT
easat-2730	405	1	[	[	X
easat-2730	405	2	24	24	NUM
easat-2730	405	3	]	]	PUNCT
easat-2730	405	4	.	.	PUNCT
easat-2730	406	1	alam	alam	PROPN
easat-2730	406	2	,	,	PUNCT
easat-2730	406	3	p.	p.	PROPN
easat-2730	406	4	;	;	PUNCT
easat-2730	406	5	alam	alam	PROPN
easat-2730	406	6	,	,	PUNCT
easat-2730	406	7	a.	a.	NOUN
easat-2730	406	8	;	;	PUNCT
easat-2730	406	9	anwer	anwer	NOUN
easat-2730	406	10	,	,	PUNCT
easat-2730	406	11	m.	m.	NOUN
easat-2730	406	12	k	k	PROPN
easat-2730	406	13	,	,	PUNCT
easat-2730	406	14	;	;	PUNCT
easat-2730	406	15	and	and	CCONJ
easat-2730	406	16	alqasoumi	alqasoumi	PROPN
easat-2730	406	17	,	,	PUNCT
easat-2730	406	18	s.	s.	PROPN
easat-2730	406	19	i.	i.	PROPN
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easat-2730	406	22	of	of	ADP
easat-2730	406	23	hesperidin	hesperidin	VERB
easat-2730	406	24	by	by	ADP
easat-2730	406	25	hptlc	hptlc	NOUN
easat-2730	406	26	in	in	ADP
easat-2730	406	27	different	different	ADJ
easat-2730	406	28	varieties	variety	NOUN
easat-2730	406	29	of	of	ADP
easat-2730	406	30	citrus	citrus	NOUN
easat-2730	406	31	peels	peel	NOUN
easat-2730	406	32	.	.	PUNCT
easat-2730	407	1	asian	asian	PROPN
easat-2730	407	2	pac	pac	PROPN
easat-2730	407	3	j	j	PROPN
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easat-2730	407	6	.	.	PUNCT
easat-2730	408	1	2014;4(4):262–6	2014;4(4):262–6	X
easat-2730	408	2	.	.	PUNCT
easat-2730	409	1	[	[	X
easat-2730	409	2	25	25	NUM
easat-2730	409	3	]	]	PUNCT
easat-2730	409	4	.	.	PUNCT
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easat-2730	410	4	h.	h.	PROPN
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easat-2730	410	7	and	and	CCONJ
easat-2730	410	8	immunity	immunity	NOUN
easat-2730	410	9	in	in	ADP
easat-2730	410	10	diseases	disease	NOUN
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easat-2730	410	12	the	the	DET
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easat-2730	410	14	tree	tree	NOUN
easat-2730	410	15	:	:	PUNCT
easat-2730	410	16	players	player	NOUN
easat-2730	410	17	and	and	CCONJ
easat-2730	410	18	`	`	PUNCT
easat-2730	410	19	.	.	PUNCT
easat-2730	411	1	circ	circ	PROPN
easat-2730	411	2	res	re	NOUN
easat-2730	411	3	.	.	PUNCT
easat-2730	412	1	2015;116:307–11	2015;116:307–11	NOUN
easat-2730	412	2	.	.	PUNCT
easat-2730	413	1	[	[	X
easat-2730	413	2	26	26	NUM
easat-2730	413	3	]	]	PUNCT
easat-2730	413	4	.	.	PUNCT
easat-2730	414	1	zeng	zeng	PROPN
easat-2730	414	2	,	,	PUNCT
easat-2730	414	3	z.	z.	PROPN
easat-2730	414	4	;	;	PUNCT
easat-2730	414	5	cao	cao	PROPN
easat-2730	414	6	,	,	PUNCT
easat-2730	414	7	b.	b.	PROPN
easat-2730	414	8	;	;	PUNCT
easat-2730	414	9	guo	guo	PROPN
easat-2730	414	10	,	,	PUNCT
easat-2730	414	11	x.	x.	PROPN
easat-2730	414	12	;	;	PUNCT
easat-2730	414	13	li	li	PROPN
easat-2730	414	14	,	,	PUNCT
easat-2730	414	15	w.	w.	PROPN
easat-2730	414	16	;	;	PUNCT
easat-2730	414	17	li	li	PROPN
easat-2730	414	18	,	,	PUNCT
easat-2730	414	19	s.	s.	PROPN
easat-2730	414	20	;	;	PUNCT
easat-2730	414	21	chen	chen	PROPN
easat-2730	414	22	,	,	PUNCT
easat-2730	414	23	j	j	PROPN
easat-2730	414	24	,	,	PUNCT
easat-2730	414	25	et	et	PROPN
easat-2730	414	26	al	al	PROPN
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easat-2730	414	29	b-100	b-100	ADP
easat-2730	414	30	peptide	peptide	VERB
easat-2730	414	31	210	210	NUM
easat-2730	414	32	antibody	antibody	NOUN
easat-2730	414	33	inhibits	inhibit	VERB
easat-2730	414	34	atherosclerosis	atherosclerosis	NOUN
easat-2730	414	35	by	by	ADP
easat-2730	414	36	regulation	regulation	NOUN
easat-2730	414	37	of	of	ADP
easat-2730	414	38	macrophages	macrophage	NOUN
easat-2730	414	39	that	that	PRON
easat-2730	414	40	phagocytize	phagocytize	VERB
easat-2730	414	41	oxidized	oxidize	VERB
easat-2730	414	42	lipid	lipid	NOUN
easat-2730	414	43	.	.	PUNCT
easat-2730	415	1	am	be	AUX
easat-2730	415	2	j	j	PROPN
easat-2730	415	3	transl	transl	PROPN
easat-2730	415	4	res	re	NOUN
easat-2730	415	5	.	.	PUNCT
easat-2730	416	1	2018;10(6):1817–28	2018;10(6):1817–28	PROPN
easat-2730	416	2	.	.	PUNCT
easat-2730	417	1	[	[	X
easat-2730	417	2	27	27	NUM
easat-2730	417	3	]	]	PUNCT
easat-2730	417	4	.	.	PUNCT
easat-2730	418	1	kwaifa	kwaifa	PROPN
easat-2730	418	2	,	,	PUNCT
easat-2730	418	3	i.	i.	PROPN
easat-2730	418	4	k.	k.	PROPN
easat-2730	418	5	anticoagulant	anticoagulant	PROPN
easat-2730	418	6	and	and	CCONJ
easat-2730	418	7	hypercoagulability	hypercoagulability	NOUN
easat-2730	418	8	.	.	PUNCT
easat-2730	419	1	we	we	PRON
easat-2730	419	2	are	be	AUX
easat-2730	419	3	intechopen	intechopen	ADJ
easat-2730	419	4	,	,	PUNCT
easat-2730	419	5	the	the	DET
easat-2730	419	6	world	world	NOUN
easat-2730	419	7	’	'	PUNCT
easat-2730	419	8	s	s	PART
easat-2730	419	9	leading	lead	VERB
easat-2730	419	10	publisher	publisher	NOUN
easat-2730	419	11	of	of	ADP
easat-2730	419	12	open	open	ADJ
easat-2730	419	13	access	access	NOUN
easat-2730	419	14	books	book	NOUN
easat-2730	419	15	built	build	VERB
easat-2730	419	16	by	by	ADP
easat-2730	419	17	scientists	scientist	NOUN
easat-2730	419	18	,	,	PUNCT
easat-2730	419	19	for	for	ADP
easat-2730	419	20	scientists	scientist	NOUN
easat-2730	419	21	top	top	VERB
easat-2730	419	22	1	1	NUM
easat-2730	419	23	%	%	NOUN
easat-2730	419	24	and	and	CCONJ
easat-2730	419	25	hypercoagulability	hypercoagulability	NOUN
easat-2730	419	26	.	.	PUNCT
easat-2730	420	1	2022;doi	2022;doi	NUM
easat-2730	420	2	:	:	PUNCT
easat-2730	420	3	http	http	ADJ
easat-2730	420	4	:	:	PUNCT
easat-2730	421	1	[	[	X
easat-2730	421	2	28	28	NUM
easat-2730	421	3	]	]	PUNCT
easat-2730	421	4	.	.	PUNCT
easat-2730	422	1	wu	wu	PROPN
easat-2730	422	2	,	,	PUNCT
easat-2730	422	3	m.	m.	NOUN
easat-2730	422	4	y.	y.	PROPN
easat-2730	422	5	;	;	PUNCT
easat-2730	422	6	li	li	PROPN
easat-2730	422	7	,	,	PUNCT
easat-2730	422	8	c.	c.	PROPN
easat-2730	422	9	j.	j.	PROPN
easat-2730	422	10	;	;	PUNCT
easat-2730	422	11	hou	hou	PROPN
easat-2730	422	12	,	,	PUNCT
easat-2730	422	13	m.	m.	PROPN
easat-2730	422	14	f.	f.	PROPN
easat-2730	422	15	;	;	PUNCT
easat-2730	422	16	and	and	CCONJ
easat-2730	422	17	chu	chu	PROPN
easat-2730	422	18	,	,	PUNCT
easat-2730	422	19	p.	p.	NOUN
easat-2730	422	20	y.	y.	PROPN
easat-2730	423	1	new	new	ADJ
easat-2730	423	2	insights	insight	NOUN
easat-2730	423	3	into	into	ADP
easat-2730	423	4	the	the	DET
easat-2730	423	5	role	role	NOUN
easat-2730	423	6	of	of	ADP
easat-2730	423	7	inflammation	inflammation	NOUN
easat-2730	423	8	in	in	ADP
easat-2730	423	9	the	the	DET
easat-2730	423	10	pathogenesis	pathogenesis	NOUN
easat-2730	423	11	of	of	ADP
easat-2730	423	12	atherosclerosis	atherosclerosis	NOUN
easat-2730	423	13	.	.	PUNCT
easat-2730	424	1	int	int	PROPN
easat-2730	424	2	j	j	PROPN
easat-2730	424	3	mol	mol	ADP
easat-2730	424	4	sci	sci	PROPN
easat-2730	424	5	.	.	PROPN
easat-2730	424	6	2017;18(10	2017;18(10	NUM
easat-2730	424	7	)	)	PUNCT
easat-2730	424	8	.	.	PUNCT
easat-2730	425	1	[	[	X
easat-2730	425	2	29	29	NUM
easat-2730	425	3	]	]	PUNCT
easat-2730	425	4	.	.	PUNCT
easat-2730	426	1	badimon	badimon	PROPN
easat-2730	426	2	,	,	PUNCT
easat-2730	426	3	l.	l.	PROPN
easat-2730	426	4	c	c	NOUN
easat-2730	426	5	-	-	ADJ
easat-2730	426	6	reactive	reactive	ADJ
easat-2730	426	7	protein	protein	NOUN
easat-2730	426	8	in	in	ADP
easat-2730	426	9	atherothrombosis	atherothrombosis	NOUN
easat-2730	426	10	and	and	CCONJ
easat-2730	426	11	angiogenesis	angiogenesis	NOUN
easat-2730	426	12	.	.	PUNCT
easat-2730	427	1	2018;9(march):1–7	2018;9(march):1–7	X
easat-2730	427	2	.	.	PUNCT
easat-2730	428	1	[	[	X
easat-2730	428	2	30	30	NUM
easat-2730	428	3	]	]	PUNCT
easat-2730	428	4	.	.	PUNCT
easat-2730	429	1	ogut	ogut	NOUN
easat-2730	429	2	,	,	PUNCT
easat-2730	429	3	o.	o.	PROPN
easat-2730	429	4	b.	b.	PROPN
easat-2730	429	5	f.	f.	PROPN
easat-2730	429	6	regulation	regulation	PROPN
easat-2730	429	7	of	of	ADP
easat-2730	429	8	force	force	NOUN
easat-2730	429	9	in	in	ADP
easat-2730	429	10	vascular	vascular	ADJ
easat-2730	429	11	smooth	smooth	ADJ
easat-2730	429	12	muscle	muscle	NOUN
easat-2730	429	13	.	.	PUNCT
easat-2730	429	14	.	.	PUNCT
easat-2730	430	1	j	j	PROPN
easat-2730	430	2	mol	mol	PROPN
easat-2730	430	3	cell	cell	NOUN
easat-2730	430	4	cardiol	cardiol	NOUN
easat-2730	430	5	.	.	PUNCT
easat-2730	431	1	2003;35:347–55	2003;35:347–55	X
easat-2730	431	2	.	.	PUNCT
easat-2730	432	1	[	[	X
easat-2730	432	2	31	31	NUM
easat-2730	432	3	]	]	PUNCT
easat-2730	432	4	.	.	PUNCT
easat-2730	433	1	vilahur	vilahur	PROPN
easat-2730	433	2	,	,	PUNCT
easat-2730	433	3	g.	g.	PROPN
easat-2730	433	4	;	;	PUNCT
easat-2730	433	5	and	and	CCONJ
easat-2730	433	6	ben	ben	PROPN
easat-2730	433	7	-	-	PUNCT
easat-2730	433	8	aicha	aicha	PROPN
easat-2730	433	9	,	,	PUNCT
easat-2730	433	10	s.	s.	PROPN
easat-2730	433	11	b.	b.	PROPN
easat-2730	433	12	l.	l.	PROPN
easat-2730	434	1	new	new	ADJ
easat-2730	434	2	insights	insight	NOUN
easat-2730	434	3	into	into	ADP
easat-2730	434	4	the	the	DET
easat-2730	434	5	role	role	NOUN
easat-2730	434	6	of	of	ADP
easat-2730	434	7	adipose	adipose	ADJ
easat-2730	434	8	tissue	tissue	NOUN
easat-2730	434	9	in	in	ADP
easat-2730	434	10	thrombosis	thrombosis	NOUN
easat-2730	434	11	.	.	PUNCT
easat-2730	435	1	thromb	thromb	PROPN
easat-2730	435	2	haemost	haemost	VERB
easat-2730	435	3	.	.	PUNCT
easat-2730	436	1	2017;https://do:1046–54	2017;https://do:1046–54	NUM
easat-2730	436	2	.	.	PUNCT
easat-2730	437	1	[	[	X
easat-2730	437	2	32	32	NUM
easat-2730	437	3	]	]	PUNCT
easat-2730	437	4	.	.	PUNCT
easat-2730	438	1	li	li	PROPN
easat-2730	438	2	,	,	PUNCT
easat-2730	438	3	h.	h.	PROPN
easat-2730	438	4	;	;	PUNCT
easat-2730	438	5	and	and	CCONJ
easat-2730	438	6	fǒrstermann	fǒrstermann	PROPN
easat-2730	438	7	,	,	PUNCT
easat-2730	438	8	u.	u.	NOUN
easat-2730	438	9	“	"	PUNCT
easat-2730	438	10	pharmacological	pharmacological	ADJ
easat-2730	438	11	prevention	prevention	NOUN
easat-2730	438	12	of	of	ADP
easat-2730	438	13	enos	enos	PROPN
easat-2730	438	14	uncoupling	uncouple	VERB
easat-2730	438	15	,	,	PUNCT
easat-2730	438	16	.	.	PUNCT
easat-2730	438	17	”	"	PUNCT
easat-2730	439	1	curr	curr	PROPN
easat-2730	439	2	pharm	pharm	PROPN
easat-2730	439	3	des	des	PROPN
easat-2730	439	4	.	.	PUNCT
easat-2730	440	1	2014;20(22):3595	2014;20(22):3595	NOUN
easat-2730	440	2	–	–	PUNCT
easat-2730	440	3	606	606	NUM
easat-2730	440	4	.	.	PUNCT
easat-2730	441	1	[	[	X
easat-2730	441	2	33	33	NUM
easat-2730	441	3	]	]	PUNCT
easat-2730	441	4	.	.	PUNCT
easat-2730	442	1	li	li	PROPN
easat-2730	442	2	,	,	PUNCT
easat-2730	442	3	h.	h.	PROPN
easat-2730	442	4	;	;	PUNCT
easat-2730	442	5	and	and	CCONJ
easat-2730	442	6	fǒrstermann	fǒrstermann	PROPN
easat-2730	442	7	,	,	PUNCT
easat-2730	442	8	u.	u.	NOUN
easat-2730	442	9	“	"	PUNCT
easat-2730	442	10	uncoupling	uncouple	VERB
easat-2730	442	11	of	of	ADP
easat-2730	442	12	endothelial	endothelial	NOUN
easat-2730	442	13	no	no	DET
easat-2730	442	14	synthase	synthase	NOUN
easat-2730	442	15	in	in	ADP
easat-2730	442	16	atherosclerosis	atherosclerosis	NOUN
easat-2730	442	17	and	and	CCONJ
easat-2730	442	18	vascular	vascular	ADJ
easat-2730	442	19	disease	disease	NOUN
easat-2730	442	20	,	,	PUNCT
easat-2730	442	21	.	.	PUNCT
easat-2730	442	22	”	"	PUNCT
easat-2730	443	1	curr	curr	PROPN
easat-2730	443	2	opin	opin	NOUN
easat-2730	443	3	pharmacol	pharmacol	NOUN
easat-2730	443	4	.	.	PUNCT
easat-2730	444	1	2013;13(2):161–7	2013;13(2):161–7	NUM
easat-2730	444	2	.	.	PUNCT
easat-2730	445	1	[	[	X
easat-2730	445	2	34	34	NUM
easat-2730	445	3	]	]	PUNCT
easat-2730	445	4	.	.	PUNCT
easat-2730	445	5	fujiyama	fujiyama	PROPN
easat-2730	445	6	,	,	PUNCT
easat-2730	445	7	s.	s.	PROPN
easat-2730	445	8	;	;	PUNCT
easat-2730	445	9	amano	amano	PROPN
easat-2730	445	10	,	,	PUNCT
easat-2730	445	11	k.	k.	PROPN
easat-2730	445	12	;	;	PUNCT
easat-2730	445	13	uehira	uehira	PROPN
easat-2730	445	14	,	,	PUNCT
easat-2730	445	15	k.	k.	PROPN
easat-2730	445	16	;	;	PUNCT
easat-2730	445	17	yoshida	yoshida	PROPN
easat-2730	445	18	,	,	PUNCT
easat-2730	445	19	m.	m.	NOUN
easat-2730	445	20	;	;	PUNCT
easat-2730	445	21	nishiwaki	nishiwaki	PROPN
easat-2730	445	22	,	,	PUNCT
easat-2730	445	23	y.	y.	PROPN
easat-2730	445	24	;	;	PUNCT
easat-2730	445	25	nozawa	nozawa	PROPN
easat-2730	445	26	,	,	PUNCT
easat-2730	445	27	y	y	PROPN
easat-2730	445	28	,	,	PUNCT
easat-2730	445	29	et	et	PROPN
easat-2730	445	30	al	al	PROPN
easat-2730	445	31	.	.	PUNCT
easat-2730	445	32	bone	bone	PROPN
easat-2730	445	33	marrow	marrow	PROPN
easat-2730	445	34	monocyte	monocyte	NOUN
easat-2730	445	35	lineage	lineage	NOUN
easat-2730	445	36	cells	cell	NOUN
easat-2730	445	37	adhere	adhere	VERB
easat-2730	445	38	on	on	ADP
easat-2730	445	39	injured	injure	VERB
easat-2730	445	40	endothelium	endothelium	NOUN
easat-2730	445	41	in	in	ADP
easat-2730	445	42	a	a	DET
easat-2730	445	43	monocyte	monocyte	NOUN
easat-2730	445	44	chemoattractant	chemoattractant	NOUN
easat-2730	445	45	protein-1	protein-1	PROPN
easat-2730	445	46	-	-	PUNCT
easat-2730	445	47	dependent	dependent	ADJ
easat-2730	445	48	manner	manner	NOUN
easat-2730	445	49	and	and	CCONJ
easat-2730	445	50	accelerate	accelerate	VERB
easat-2730	445	51	reendothelialization	reendothelialization	NOUN
easat-2730	445	52	as	as	ADP
easat-2730	445	53	endothelial	endothelial	ADJ
easat-2730	445	54	progenitor	progenitor	NOUN
easat-2730	445	55	cells	cell	NOUN
easat-2730	445	56	.	.	PUNCT
easat-2730	446	1	circ	circ	PROPN
easat-2730	446	2	res	re	NOUN
easat-2730	446	3	.	.	PUNCT
easat-2730	447	1	2003;93(10):980–9	2003;93(10):980–9	ADV
easat-2730	447	2	.	.	PUNCT
easat-2730	448	1	[	[	X
easat-2730	448	2	35	35	NUM
easat-2730	448	3	]	]	SYM
easat-2730	448	4	.	.	PUNCT
easat-2730	448	5	lobato	lobato	PROPN
easat-2730	448	6	,	,	PUNCT
easat-2730	448	7	n.	n.	PROPN
easat-2730	448	8	s.	s.	PROPN
easat-2730	448	9	;	;	PUNCT
easat-2730	448	10	filgueira	filgueira	PROPN
easat-2730	448	11	,	,	PUNCT
easat-2730	448	12	f.	f.	PROPN
easat-2730	448	13	p.	p.	PROPN
easat-2730	448	14	;	;	PUNCT
easat-2730	448	15	akamine	akamine	PROPN
easat-2730	448	16	,	,	PUNCT
easat-2730	448	17	e.	e.	PROPN
easat-2730	448	18	h.	h.	PROPN
easat-2730	448	19	;	;	PUNCT
easat-2730	448	20	tostes	tostes	PROPN
easat-2730	448	21	,	,	PUNCT
easat-2730	448	22	r.	r.	PROPN
easat-2730	448	23	c.	c.	PROPN
easat-2730	448	24	;	;	PUNCT
easat-2730	448	25	carvalho	carvalho	PROPN
easat-2730	448	26	,	,	PUNCT
easat-2730	448	27	m.	m.	PROPN
easat-2730	448	28	h.	h.	PROPN
easat-2730	448	29	c.	c.	PROPN
easat-2730	448	30	;	;	PUNCT
easat-2730	448	31	and	and	CCONJ
easat-2730	448	32	fortes	fortis	NOUN
easat-2730	448	33	,	,	PUNCT
easat-2730	448	34	z.	z.	PROPN
easat-2730	448	35	b.	b.	PROPN
easat-2730	448	36	mechanisms	mechanism	NOUN
easat-2730	448	37	of	of	ADP
easat-2730	448	38	endothelial	endothelial	ADJ
easat-2730	448	39	dysfunction	dysfunction	NOUN
easat-2730	448	40	in	in	ADP
easat-2730	448	41	obesity	obesity	NOUN
easat-2730	448	42	-	-	PUNCT
easat-2730	448	43	associated	associate	VERB
easat-2730	448	44	hypertension	hypertension	NOUN
easat-2730	448	45	mechanisms	mechanism	NOUN
easat-2730	448	46	of	of	ADP
easat-2730	448	47	endothelial	endothelial	ADJ
easat-2730	448	48	dysfunction	dysfunction	NOUN
easat-2730	448	49	in	in	ADP
easat-2730	448	50	obesityassociated	obesityassociated	ADJ
easat-2730	448	51	hypertension	hypertension	NOUN
easat-2730	448	52	.	.	PUNCT
easat-2730	449	1	2012;45(may	2012;45(may	NUM
easat-2730	449	2	)	)	PUNCT
easat-2730	449	3	.	.	PUNCT
easat-2730	450	1	[	[	X
easat-2730	450	2	36	36	NUM
easat-2730	450	3	]	]	SYM
easat-2730	450	4	.	.	PUNCT
easat-2730	450	5	ahluwalia	ahluwalia	PROPN
easat-2730	450	6	,	,	PUNCT
easat-2730	450	7	a.	a.	NOUN
easat-2730	450	8	;	;	PUNCT
easat-2730	450	9	foster	foster	ADJ
easat-2730	450	10	,	,	PUNCT
easat-2730	450	11	p.	p.	NOUN
easat-2730	450	12	;	;	PUNCT
easat-2730	450	13	scotland	scotland	PROPN
easat-2730	450	14	,	,	PUNCT
easat-2730	450	15	r.	r.	PROPN
easat-2730	450	16	s	s	PROPN
easat-2730	450	17	,	,	PUNCT
easat-2730	450	18	et	et	PROPN
easat-2730	450	19	al	al	PROPN
easat-2730	450	20	.	.	PROPN
easat-2730	450	21	antiinflammatory	antiinflammatory	NOUN
easat-2730	450	22	activity	activity	NOUN
easat-2730	450	23	of	of	ADP
easat-2730	450	24	soluble	soluble	ADJ
easat-2730	450	25	guanylate	guanylate	NOUN
easat-2730	450	26	cyclase	cyclase	NOUN
easat-2730	450	27	:	:	PUNCT
easat-2730	450	28	cgmpdependent	cgmpdependent	VERB
easat-2730	450	29	down	down	ADP
easat-2730	450	30	-	-	PUNCT
easat-2730	450	31	regulation	regulation	NOUN
easat-2730	450	32	of	of	ADP
easat-2730	450	33	p	p	NOUN
easat-2730	450	34	-	-	PUNCT
easat-2730	450	35	selectin	selectin	ADJ
easat-2730	450	36	expression	expression	NOUN
easat-2730	450	37	and	and	CCONJ
easat-2730	450	38	leukocyte	leukocyte	NOUN
easat-2730	450	39	recruitment	recruitment	NOUN
easat-2730	450	40	.	.	PUNCT
easat-2730	451	1	proc	proc	PROPN
easat-2730	451	2	natl	natl	PROPN
easat-2730	451	3	acad	acad	PROPN
easat-2730	451	4	sci	sci	PROPN
easat-2730	451	5	usa	usa	PROPN
easat-2730	451	6	.	.	PROPN
easat-2730	451	7	2004;101:1386–91	2004;101:1386–91	NUM
easat-2730	451	8	.	.	PUNCT
easat-2730	452	1	[	[	X
easat-2730	452	2	37	37	NUM
easat-2730	452	3	]	]	PUNCT
easat-2730	452	4	.	.	PUNCT
easat-2730	453	1	blokhin	blokhin	PROPN
easat-2730	453	2	,	,	PUNCT
easat-2730	453	3	i.	i.	PROPN
easat-2730	453	4	o.	o.	PROPN
easat-2730	453	5	;	;	PUNCT
easat-2730	453	6	lentz	lentz	PROPN
easat-2730	453	7	,	,	PUNCT
easat-2730	453	8	s.	s.	PROPN
easat-2730	453	9	r.	r.	PROPN
easat-2730	453	10	;	;	PUNCT
easat-2730	453	11	and	and	CCONJ
easat-2730	453	12	city	city	NOUN
easat-2730	453	13	,	,	PUNCT
easat-2730	453	14	i.	i.	NOUN
easat-2730	453	15	mechanisms	mechanism	NOUN
easat-2730	453	16	of	of	ADP
easat-2730	453	17	thrombosis	thrombosis	NOUN
easat-2730	453	18	in	in	ADP
easat-2730	453	19	obesity	obesity	NOUN
easat-2730	453	20	.	.	PUNCT
easat-2730	454	1	2015;20(5):437–44	2015;20(5):437–44	NUM
easat-2730	454	2	.	.	PUNCT
easat-2730	455	1	[	[	X
easat-2730	455	2	38	38	NUM
easat-2730	455	3	]	]	PUNCT
easat-2730	455	4	.	.	PUNCT
easat-2730	456	1	gilchrist	gilchrist	PROPN
easat-2730	456	2	,	,	PUNCT
easat-2730	456	3	m.	m.	NOUN
easat-2730	456	4	;	;	PUNCT
easat-2730	456	5	and	and	CCONJ
easat-2730	456	6	hesslinger	hesslinger	PROPN
easat-2730	456	7	,	,	PUNCT
easat-2730	456	8	c.	c.	PROPN
easat-2730	456	9	b.	b.	PROPN
easat-2730	456	10	a.	a.	PROPN
easat-2730	456	11	tetrahydrobiopterin	tetrahydrobiopterin	PROPN
easat-2730	456	12	,	,	PUNCT
easat-2730	456	13	a	a	DET
easat-2730	456	14	critical	critical	ADJ
easat-2730	456	15	factor	factor	NOUN
easat-2730	456	16	in	in	ADP
easat-2730	456	17	the	the	DET
easat-2730	456	18	production	production	NOUN
easat-2730	456	19	and	and	CCONJ
easat-2730	456	20	role	role	NOUN
easat-2730	456	21	of	of	ADP
easat-2730	456	22	nitric	nitric	ADJ
easat-2730	456	23	oxide	oxide	NOUN
easat-2730	456	24	in	in	ADP
easat-2730	456	25	mast	mast	NOUN
easat-2730	456	26	cells	cell	NOUN
easat-2730	456	27	.	.	PUNCT
easat-2730	457	1	j	j	PROPN
easat-2730	457	2	biol	biol	PROPN
easat-2730	457	3	chem	chem	NOUN
easat-2730	457	4	.	.	PUNCT
easat-2730	458	1	2003;278:50607–14	2003;278:50607–14	X
easat-2730	458	2	.	.	PUNCT
easat-2730	459	1	[	[	X
easat-2730	459	2	39	39	NUM
easat-2730	459	3	]	]	PUNCT
easat-2730	459	4	.	.	PUNCT
easat-2730	459	5	viles	vile	NOUN
easat-2730	459	6	-	-	PUNCT
easat-2730	459	7	gonzalez	gonzalez	PROPN
easat-2730	459	8	,	,	PUNCT
easat-2730	459	9	j.	j.	PROPN
easat-2730	459	10	f.	f.	PROPN
easat-2730	459	11	;	;	PUNCT
easat-2730	459	12	fuster	fuster	PROPN
easat-2730	459	13	,	,	PUNCT
easat-2730	459	14	v.	v.	ADV
easat-2730	459	15	;	;	PUNCT
easat-2730	459	16	and	and	CCONJ
easat-2730	459	17	badimon	badimon	NOUN
easat-2730	459	18	,	,	PUNCT
easat-2730	459	19	j.	j.	PROPN
easat-2730	459	20	j.	j.	PROPN
easat-2730	459	21	atherothrombosis	atherothrombosis	PROPN
easat-2730	459	22	:	:	PUNCT
easat-2730	459	23	a	a	DET
easat-2730	459	24	widespread	widespread	ADJ
easat-2730	459	25	disease	disease	NOUN
easat-2730	459	26	with	with	ADP
easat-2730	459	27	unpredictable	unpredictable	ADJ
easat-2730	459	28	and	and	CCONJ
easat-2730	459	29	life	life	NOUN
easat-2730	459	30	-	-	PUNCT
easat-2730	459	31	threatening	threaten	VERB
easat-2730	459	32	consequences	consequence	NOUN
easat-2730	459	33	.	.	PUNCT
easat-2730	460	1	eur	eur	ADJ
easat-2730	460	2	heart	heart	NOUN
easat-2730	460	3	j.	j.	PROPN
easat-2730	460	4	2004;25(14):1197–207	2004;25(14):1197–207	PROPN
easat-2730	460	5	.	.	PUNCT
easat-2730	461	1	[	[	X
easat-2730	461	2	40	40	NUM
easat-2730	461	3	]	]	PUNCT
easat-2730	461	4	.	.	PUNCT
easat-2730	462	1	jia	jia	PROPN
easat-2730	462	2	,	,	PUNCT
easat-2730	462	3	g.	g.	PROPN
easat-2730	462	4	;	;	PUNCT
easat-2730	462	5	aroor	aroor	ADJ
easat-2730	462	6	,	,	PUNCT
easat-2730	462	7	a.	a.	PROPN
easat-2730	462	8	r.	r.	PROPN
easat-2730	462	9	;	;	PUNCT
easat-2730	462	10	jia	jia	PROPN
easat-2730	462	11	,	,	PUNCT
easat-2730	462	12	c.	c.	PROPN
easat-2730	462	13	;	;	PUNCT
easat-2730	462	14	abd	abd	PROPN
easat-2730	462	15	sowers	sower	NOUN
easat-2730	462	16	,	,	PUNCT
easat-2730	462	17	j.	j.	PROPN
easat-2730	462	18	r.	r.	PROPN
easat-2730	462	19	endothelial	endothelial	PROPN
easat-2730	462	20	cell	cell	NOUN
easat-2730	462	21	senescence	senescence	NOUN
easat-2730	462	22	in	in	ADP
easat-2730	462	23	aging	age	VERB
easat-2730	462	24	-	-	PUNCT
easat-2730	462	25	related	relate	VERB
easat-2730	462	26	vascular	vascular	ADJ
easat-2730	462	27	dysfunction	dysfunction	NOUN
easat-2730	462	28	.	.	PUNCT
easat-2730	463	1	biochim	biochim	PROPN
easat-2730	463	2	biophys	biophy	NOUN
easat-2730	463	3	acta	acta	PROPN
easat-2730	463	4	mol	mol	ADP
easat-2730	463	5	basis	basis	NOUN
easat-2730	463	6	dis	dis	PROPN
easat-2730	464	1	[	[	X
easat-2730	464	2	internet	internet	NOUN
easat-2730	464	3	]	]	PUNCT
easat-2730	464	4	.	.	PUNCT
easat-2730	465	1	2019;1865(7):1802–9	2019;1865(7):1802–9	X
easat-2730	465	2	.	.	PUNCT
easat-2730	465	3	available	available	ADJ
easat-2730	465	4	from	from	ADP
easat-2730	465	5	:	:	PUNCT
easat-2730	465	6	https://doi.org/10.1016/j.bbadis.2018.08.008	https://doi.org/10.1016/j.bbadis.2018.08.008	NOUN
easat-2730	465	7	[	[	X
easat-2730	465	8	41	41	NUM
easat-2730	465	9	]	]	PUNCT
easat-2730	465	10	.	.	PUNCT
easat-2730	466	1	hansel	hansel	PROPN
easat-2730	466	2	,	,	PUNCT
easat-2730	466	3	b.	b.	PROPN
easat-2730	466	4	;	;	PUNCT
easat-2730	466	5	roussel	roussel	PROPN
easat-2730	466	6	,	,	PUNCT
easat-2730	466	7	r.	r.	PROPN
easat-2730	466	8	;	;	PUNCT
easat-2730	466	9	elbez	elbez	PROPN
easat-2730	466	10	,	,	PUNCT
easat-2730	466	11	y.	y.	PROPN
easat-2730	466	12	;	;	PUNCT
easat-2730	466	13	marre	marre	X
easat-2730	466	14	,	,	PUNCT
easat-2730	466	15	m.	m.	NOUN
easat-2730	466	16	;	;	PUNCT
easat-2730	466	17	krempf	krempf	NOUN
easat-2730	466	18	,	,	PUNCT
easat-2730	466	19	m.	m.	NOUN
easat-2730	466	20	;	;	PUNCT
easat-2730	466	21	ikeda	ikeda	PROPN
easat-2730	466	22	,	,	PUNCT
easat-2730	466	23	y	y	PROPN
easat-2730	466	24	,	,	PUNCT
easat-2730	466	25	et	et	PROPN
easat-2730	466	26	al	al	PROPN
easat-2730	466	27	.	.	PUNCT
easat-2730	467	1	cardiovascular	cardiovascular	ADJ
easat-2730	467	2	risk	risk	NOUN
easat-2730	467	3	in	in	ADP
easat-2730	467	4	relation	relation	NOUN
easat-2730	467	5	to	to	ADP
easat-2730	467	6	body	body	NOUN
easat-2730	467	7	mass	mass	NOUN
easat-2730	467	8	index	index	NOUN
easat-2730	467	9	and	and	CCONJ
easat-2730	467	10	use	use	NOUN
easat-2730	467	11	of	of	ADP
easat-2730	467	12	evidence	evidence	NOUN
easat-2730	467	13	-	-	PUNCT
easat-2730	467	14	based	base	VERB
easat-2730	467	15	preventive	preventive	ADJ
easat-2730	467	16	medications	medication	NOUN
easat-2730	467	17	in	in	ADP
easat-2730	467	18	patients	patient	NOUN
easat-2730	467	19	with	with	ADP
easat-2730	467	20	or	or	CCONJ
easat-2730	467	21	at	at	ADP
easat-2730	467	22	risk	risk	NOUN
easat-2730	467	23	of	of	ADP
easat-2730	467	24	atherothrombosis	atherothrombosis	NOUN
easat-2730	467	25	.	.	PUNCT
easat-2730	468	1	eur	eur	PROPN
easat-2730	468	2	heart	heart	NOUN
easat-2730	468	3	j.	j.	PROPN
easat-2730	468	4	2015;36(40):2716–28	2015;36(40):2716–28	NUM
easat-2730	468	5	.	.	PUNCT
easat-2730	469	1	[	[	X
easat-2730	469	2	42	42	NUM
easat-2730	469	3	]	]	PUNCT
easat-2730	469	4	.	.	PUNCT
easat-2730	470	1	yau	yau	PROPN
easat-2730	470	2	,	,	PUNCT
easat-2730	470	3	j.	j.	PROPN
easat-2730	470	4	w.	w.	PROPN
easat-2730	470	5	;	;	PUNCT
easat-2730	470	6	teoh	teoh	PROPN
easat-2730	470	7	,	,	PUNCT
easat-2730	470	8	h.	h.	PROPN
easat-2730	470	9	;	;	PUNCT
easat-2730	470	10	and	and	CCONJ
easat-2730	470	11	verma	verma	PROPN
easat-2730	470	12	,	,	PUNCT
easat-2730	470	13	s.	s.	PROPN
easat-2730	470	14	endothelial	endothelial	ADJ
easat-2730	470	15	cell	cell	NOUN
easat-2730	470	16	control	control	NOUN
easat-2730	470	17	of	of	ADP
easat-2730	470	18	thrombosis	thrombosis	NOUN
easat-2730	470	19	.	.	PUNCT
easat-2730	471	1	bmc	bmc	PROPN
easat-2730	471	2	cardiovasc	cardiovasc	PROPN
easat-2730	471	3	disord	disord	PROPN
easat-2730	472	1	[	[	X
easat-2730	472	2	internet	internet	NOUN
easat-2730	472	3	]	]	PUNCT
easat-2730	472	4	.	.	PUNCT
easat-2730	473	1	2015;15(1):1–11	2015;15(1):1–11	X
easat-2730	473	2	.	.	PUNCT
easat-2730	473	3	available	available	ADJ
easat-2730	473	4	from	from	ADP
easat-2730	473	5	:	:	PUNCT
easat-2730	473	6	http://dx.doi.org/10.1186/s12872-015-0124-z	http://dx.doi.org/10.1186/s12872-015-0124-z	PROPN
easat-2730	473	7	3456	3456	NUM
easat-2730	473	8	edelweiss	edelweiss	PROPN
easat-2730	473	9	applied	apply	VERB
easat-2730	473	10	science	science	NOUN
easat-2730	473	11	and	and	CCONJ
easat-2730	473	12	technology	technology	NOUN
easat-2730	473	13	issn	issn	PROPN
easat-2730	473	14	:	:	PUNCT
easat-2730	473	15	2576	2576	NUM
easat-2730	473	16	-	-	SYM
easat-2730	473	17	8484	8484	NUM
easat-2730	473	18	vol	vol	NOUN
easat-2730	473	19	.	.	PROPN
easat-2730	473	20	8	8	NUM
easat-2730	473	21	,	,	PUNCT
easat-2730	473	22	no	no	INTJ
easat-2730	473	23	.	.	NOUN
easat-2730	474	1	6	6	NUM
easat-2730	474	2	:	:	SYM
easat-2730	474	3	3441	3441	NUM
easat-2730	474	4	-	-	SYM
easat-2730	474	5	3456	3456	NUM
easat-2730	474	6	,	,	PUNCT
easat-2730	474	7	2024	2024	NUM
easat-2730	474	8	doi	doi	NOUN
easat-2730	474	9	:	:	PUNCT
easat-2730	474	10	10.55214/25768484.v8i6.2730	10.55214/25768484.v8i6.2730	NUM
easat-2730	474	11	©	©	ADP
easat-2730	474	12	2024	2024	NUM
easat-2730	474	13	by	by	ADP
easat-2730	474	14	the	the	DET
easat-2730	474	15	authors	author	NOUN
easat-2730	474	16	;	;	PUNCT
easat-2730	474	17	licensee	licensee	PROPN
easat-2730	474	18	learning	learning	NOUN
easat-2730	474	19	gate	gate	NOUN
easat-2730	475	1	[	[	X
easat-2730	475	2	43	43	NUM
easat-2730	475	3	]	]	PUNCT
easat-2730	475	4	.	.	PUNCT
easat-2730	476	1	lundberg	lundberg	PROPN
easat-2730	476	2	,	,	PUNCT
easat-2730	476	3	j.	j.	PROPN
easat-2730	476	4	o.	o.	PROPN
easat-2730	476	5	;	;	PUNCT
easat-2730	476	6	gladwin	gladwin	PROPN
easat-2730	476	7	,	,	PUNCT
easat-2730	476	8	m.	m.	NOUN
easat-2730	476	9	t.	t.	PROPN
easat-2730	476	10	;	;	PUNCT
easat-2730	476	11	and	and	CCONJ
easat-2730	476	12	weitzberg	weitzberg	PROPN
easat-2730	476	13	,	,	PUNCT
easat-2730	476	14	e.	e.	PROPN
easat-2730	476	15	“	"	PUNCT
easat-2730	476	16	strategies	strategy	NOUN
easat-2730	476	17	to	to	PART
easat-2730	476	18	increase	increase	VERB
easat-2730	476	19	nitric	nitric	ADJ
easat-2730	476	20	oxide	oxide	NOUN
easat-2730	476	21	signalling	signal	VERB
easat-2730	476	22	in	in	ADP
easat-2730	476	23	cardiovascular	cardiovascular	ADJ
easat-2730	476	24	disease	disease	NOUN
easat-2730	476	25	,	,	PUNCT
easat-2730	476	26	.	.	PUNCT
easat-2730	476	27	”	"	PUNCT
easat-2730	477	1	nat	nat	PROPN
easat-2730	477	2	rev	rev	VERB
easat-2730	477	3	drug	drug	NOUN
easat-2730	477	4	discov	discov	NOUN
easat-2730	477	5	.	.	PUNCT
easat-2730	478	1	2015;14(9):623–41	2015;14(9):623–41	NUM
easat-2730	478	2	.	.	PUNCT
easat-2730	479	1	[	[	X
easat-2730	479	2	44	44	NUM
easat-2730	479	3	]	]	PUNCT
easat-2730	479	4	.	.	PUNCT
easat-2730	480	1	ghiadoni	ghiadoni	PROPN
easat-2730	480	2	,	,	PUNCT
easat-2730	480	3	l.	l.	PROPN
easat-2730	480	4	;	;	PUNCT
easat-2730	480	5	taddei	taddei	PROPN
easat-2730	480	6	,	,	PUNCT
easat-2730	480	7	s.	s.	PROPN
easat-2730	480	8	;	;	PUNCT
easat-2730	480	9	and	and	CCONJ
easat-2730	480	10	virdis	virdis	PROPN
easat-2730	480	11	,	,	PUNCT
easat-2730	480	12	a.	a.	NOUN
easat-2730	480	13	hypertension	hypertension	NOUN
easat-2730	480	14	and	and	CCONJ
easat-2730	480	15	endothelial	endothelial	ADJ
easat-2730	480	16	dysfunction	dysfunction	NOUN
easat-2730	480	17	:	:	PUNCT
easat-2730	480	18	therapeutic	therapeutic	ADJ
easat-2730	480	19	approach	approach	NOUN
easat-2730	480	20	,	,	PUNCT
easat-2730	480	21	.	.	PUNCT
easat-2730	481	1	curr	curr	PROPN
easat-2730	481	2	vasc	vasc	PROPN
easat-2730	481	3	pharmacol	pharmacol	PROPN
easat-2730	481	4	.	.	PUNCT
easat-2730	482	1	2012;10(1):42–60	2012;10(1):42–60	X
easat-2730	482	2	.	.	PUNCT
easat-2730	483	1	[	[	X
easat-2730	483	2	45	45	NUM
easat-2730	483	3	]	]	PUNCT
easat-2730	483	4	.	.	PUNCT
easat-2730	483	5	antoniades	antoniade	NOUN
easat-2730	483	6	,	,	PUNCT
easat-2730	483	7	c.	c.	PROPN
easat-2730	483	8	;	;	PUNCT
easat-2730	483	9	bakogiannis	bakogiannis	PROPN
easat-2730	483	10	,	,	PUNCT
easat-2730	483	11	c.	c.	PROPN
easat-2730	483	12	;	;	PUNCT
easat-2730	483	13	leeson	leeson	PROPN
easat-2730	483	14	,	,	PUNCT
easat-2730	483	15	p.	p.	NOUN
easat-2730	483	16	et	et	NOUN
easat-2730	484	1	al	al	PROPN
easat-2730	484	2	.	.	PUNCT
easat-2730	485	1	“	"	PUNCT
easat-2730	485	2	rapid	rapid	ADJ
easat-2730	485	3	,	,	PUNCT
easat-2730	485	4	direct	direct	ADJ
easat-2730	485	5	effects	effect	NOUN
easat-2730	485	6	of	of	ADP
easat-2730	485	7	statin	statin	ADJ
easat-2730	485	8	treatment	treatment	NOUN
easat-2730	485	9	on	on	ADP
easat-2730	485	10	arterial	arterial	ADJ
easat-2730	485	11	redox	redox	ADJ
easat-2730	485	12	state	state	NOUN
easat-2730	485	13	and	and	CCONJ
easat-2730	485	14	nitric	nitric	ADJ
easat-2730	485	15	oxide	oxide	NOUN
easat-2730	485	16	bioavailability	bioavailability	NOUN
easat-2730	485	17	in	in	ADP
easat-2730	485	18	human	human	ADJ
easat-2730	485	19	atherosclerosis	atherosclerosis	NOUN
easat-2730	485	20	via	via	ADP
easat-2730	485	21	tetrahydrobiopterinmediated	tetrahydrobiopterinmediate	VERB
easat-2730	485	22	endothelial	endothelial	ADJ
easat-2730	485	23	nitric	nitric	ADJ
easat-2730	485	24	oxide	oxide	NOUN
easat-2730	485	25	synthase	synthase	NOUN
easat-2730	485	26	coupling	coupling	NOUN
easat-2730	485	27	,	,	PUNCT
easat-2730	485	28	.	.	PUNCT
easat-2730	485	29	”	"	PUNCT
easat-2730	485	30	circulation	circulation	NOUN
easat-2730	485	31	.	.	PUNCT
easat-2730	486	1	2011;124(3):335–45	2011;124(3):335–45	NUM
easat-2730	486	2	.	.	PUNCT
easat-2730	487	1	[	[	X
easat-2730	487	2	46	46	NUM
easat-2730	487	3	]	]	PUNCT
easat-2730	487	4	.	.	PUNCT
easat-2730	488	1	conti	conti	PROPN
easat-2730	488	2	,	,	PUNCT
easat-2730	488	3	v.	v.	PROPN
easat-2730	488	4	;	;	PUNCT
easat-2730	488	5	russomanno	russomanno	ADV
easat-2730	488	6	,	,	PUNCT
easat-2730	488	7	g.	g.	PROPN
easat-2730	488	8	;	;	PUNCT
easat-2730	488	9	corbi	corbi	PROPN
easat-2730	488	10	,	,	PUNCT
easat-2730	488	11	g.	g.	PROPN
easat-2730	488	12	;	;	PUNCT
easat-2730	488	13	izzo	izzo	PROPN
easat-2730	488	14	,	,	PUNCT
easat-2730	488	15	v.	v.	PROPN
easat-2730	488	16	;	;	PUNCT
easat-2730	488	17	vecchione	vecchione	NOUN
easat-2730	488	18	,	,	PUNCT
easat-2730	488	19	c.	c.	NOUN
easat-2730	488	20	;	;	PUNCT
easat-2730	488	21	and	and	CCONJ
easat-2730	488	22	filippelli	filippelli	PROPN
easat-2730	488	23	,	,	PUNCT
easat-2730	488	24	a.	a.	NOUN
easat-2730	488	25	“	"	PUNCT
easat-2730	488	26	adrenoreceptors	adrenoreceptor	NOUN
easat-2730	488	27	and	and	CCONJ
easat-2730	488	28	nitric	nitric	ADJ
easat-2730	488	29	oxide	oxide	NOUN
easat-2730	488	30	in	in	ADP
easat-2730	488	31	the	the	DET
easat-2730	488	32	cardiovascular	cardiovascular	ADJ
easat-2730	488	33	system	system	NOUN
easat-2730	488	34	,	,	PUNCT
easat-2730	488	35	.	.	PUNCT
easat-2730	489	1	front	front	ADJ
easat-2730	489	2	physiol	physiol	PROPN
easat-2730	489	3	.	.	PUNCT
easat-2730	490	1	2013;4(321	2013;4(321	NUM
easat-2730	490	2	)	)	PUNCT
easat-2730	490	3	.	.	PUNCT
easat-2730	491	1	[	[	X
easat-2730	491	2	47	47	NUM
easat-2730	491	3	]	]	PUNCT
easat-2730	491	4	.	.	PUNCT
easat-2730	492	1	conti	conti	PROPN
easat-2730	492	2	,	,	PUNCT
easat-2730	492	3	v.	v.	PROPN
easat-2730	492	4	;	;	PUNCT
easat-2730	492	5	corbi	corbi	NOUN
easat-2730	492	6	,	,	PUNCT
easat-2730	492	7	g.	g.	PROPN
easat-2730	492	8	;	;	PUNCT
easat-2730	492	9	russomanno	russomanno	PROPN
easat-2730	492	10	,	,	PUNCT
easat-2730	492	11	g	g	PROPN
easat-2730	492	12	,	,	PUNCT
easat-2730	492	13	et	et	PROPN
easat-2730	492	14	al	al	PROPN
easat-2730	492	15	.	.	PUNCT
easat-2730	492	16	“	"	PUNCT
easat-2730	492	17	oxidative	oxidative	ADJ
easat-2730	492	18	stress	stress	NOUN
easat-2730	492	19	effects	effect	NOUN
easat-2730	492	20	on	on	ADP
easat-2730	492	21	endothelial	endothelial	ADJ
easat-2730	492	22	cells	cell	NOUN
easat-2730	492	23	treated	treat	VERB
easat-2730	492	24	with	with	ADP
easat-2730	492	25	different	different	ADJ
easat-2730	492	26	athletes	athlete	NOUN
easat-2730	492	27	’	'	PUNCT
easat-2730	492	28	sera	sera	NOUN
easat-2730	492	29	,	,	PUNCT
easat-2730	492	30	”	"	PUNCT
easat-2730	492	31	.	.	PUNCT
easat-2730	492	32	med	med	ADJ
easat-2730	492	33	sport	sport	NOUN
easat-2730	492	34	.	.	PUNCT
easat-2730	493	1	2012;44(1):39–49	2012;44(1):39–49	NUM
easat-2730	493	2	.	.	PUNCT
easat-2730	494	1	[	[	X
easat-2730	494	2	48	48	NUM
easat-2730	494	3	]	]	PUNCT
easat-2730	494	4	.	.	PUNCT
easat-2730	495	1	puca	puca	PROPN
easat-2730	495	2	,	,	PUNCT
easat-2730	495	3	a.	a.	NOUN
easat-2730	495	4	a.	a.	PROPN
easat-2730	495	5	;	;	PUNCT
easat-2730	495	6	carrizzo	carrizzo	VERB
easat-2730	495	7	,	,	PUNCT
easat-2730	495	8	a.	a.	NOUN
easat-2730	495	9	;	;	PUNCT
easat-2730	495	10	villa	villa	PROPN
easat-2730	495	11	,	,	PUNCT
easat-2730	495	12	e	e	PROPN
easat-2730	495	13	,	,	PUNCT
easat-2730	495	14	et	et	PROPN
easat-2730	495	15	al	al	PROPN
easat-2730	495	16	.	.	PUNCT
easat-2730	496	1	“	"	PUNCT
easat-2730	496	2	vascular	vascular	ADJ
easat-2730	496	3	ageing	ageing	NOUN
easat-2730	496	4	:	:	PUNCT
easat-2730	496	5	the	the	DET
easat-2730	496	6	role	role	NOUN
easat-2730	496	7	of	of	ADP
easat-2730	496	8	oxidative	oxidative	ADJ
easat-2730	496	9	stress	stress	NOUN
easat-2730	496	10	,	,	PUNCT
easat-2730	496	11	.	.	PUNCT
easat-2730	496	12	”	"	PUNCT
easat-2730	497	1	int	int	PROPN
easat-2730	497	2	j	j	PROPN
easat-2730	497	3	biochem	biochem	PROPN
easat-2730	497	4	cell	cell	NOUN
easat-2730	497	5	biol	biol	NOUN
easat-2730	497	6	.	.	PUNCT
easat-2730	498	1	2013;45(3):556–9	2013;45(3):556–9	NUM
easat-2730	498	2	.	.	PUNCT
easat-2730	499	1	[	[	X
easat-2730	499	2	49	49	NUM
easat-2730	499	3	]	]	PUNCT
easat-2730	499	4	.	.	PUNCT
easat-2730	500	1	farah	farah	PROPN
easat-2730	500	2	,	,	PUNCT
easat-2730	500	3	c.	c.	PROPN
easat-2730	500	4	;	;	PUNCT
easat-2730	500	5	kleindienst	kleindienst	PROPN
easat-2730	500	6	,	,	PUNCT
easat-2730	500	7	a.	a.	PROPN
easat-2730	500	8	b.	b.	PROPN
easat-2730	500	9	g	g	PROPN
easat-2730	500	10	,	,	PUNCT
easat-2730	500	11	et	et	PROPN
easat-2730	500	12	al	al	PROPN
easat-2730	500	13	.	.	PUNCT
easat-2730	501	1	“	"	PUNCT
easat-2730	501	2	exercise	exercise	NOUN
easat-2730	501	3	-	-	PUNCT
easat-2730	501	4	induced	induce	VERB
easat-2730	501	5	cardioprotection	cardioprotection	NOUN
easat-2730	501	6	:	:	PUNCT
easat-2730	501	7	a	a	DET
easat-2730	501	8	role	role	NOUN
easat-2730	501	9	for	for	ADP
easat-2730	501	10	enos	eno	NOUN
easat-2730	501	11	uncoupling	uncouple	VERB
easat-2730	501	12	and	and	CCONJ
easat-2730	501	13	no	no	DET
easat-2730	501	14	metabolites	metabolite	NOUN
easat-2730	501	15	,	,	PUNCT
easat-2730	501	16	.	.	PUNCT
easat-2730	501	17	”	"	PUNCT
easat-2730	502	1	basic	basic	ADJ
easat-2730	502	2	res	re	NOUN
easat-2730	502	3	cardiol	cardiol	NOUN
easat-2730	502	4	.	.	PUNCT
easat-2730	503	1	2013;108(6):389	2013;108(6):389	NUM
easat-2730	503	2	.	.	PUNCT
easat-2730	504	1	[	[	X
easat-2730	504	2	50	50	NUM
easat-2730	504	3	]	]	PUNCT
easat-2730	504	4	.	.	PUNCT
easat-2730	504	5	soccio	soccio	PROPN
easat-2730	504	6	,	,	PUNCT
easat-2730	504	7	m.	m.	NOUN
easat-2730	504	8	;	;	PUNCT
easat-2730	504	9	laus	laus	NOUN
easat-2730	504	10	,	,	PUNCT
easat-2730	504	11	m.	m.	NOUN
easat-2730	504	12	n.	n.	NOUN
easat-2730	504	13	;	;	PUNCT
easat-2730	504	14	flagella	flagella	NOUN
easat-2730	504	15	,	,	PUNCT
easat-2730	504	16	z	z	NOUN
easat-2730	504	17	;	;	PUNCT
easat-2730	504	18	and	and	CCONJ
easat-2730	504	19	pastore	pastore	NOUN
easat-2730	504	20	,	,	PUNCT
easat-2730	504	21	d.	d.	PROPN
easat-2730	504	22	assessment	assessment	NOUN
easat-2730	504	23	of	of	ADP
easat-2730	504	24	antioxidant	antioxidant	ADJ
easat-2730	504	25	capacity	capacity	NOUN
easat-2730	504	26	and	and	CCONJ
easat-2730	504	27	putative	putative	ADJ
easat-2730	504	28	healthy	healthy	ADJ
easat-2730	504	29	effects	effect	NOUN
easat-2730	504	30	of	of	ADP
easat-2730	504	31	natural	natural	ADJ
easat-2730	504	32	plant	plant	NOUN
easat-2730	504	33	products	product	NOUN
easat-2730	504	34	using	use	VERB
easat-2730	504	35	soybean	soybean	NOUN
easat-2730	504	36	lipoxygenase	lipoxygenase	NOUN
easat-2730	504	37	-	-	PUNCT
easat-2730	504	38	based	base	VERB
easat-2730	504	39	methods	method	NOUN
easat-2730	504	40	.	.	PUNCT
easat-2730	505	1	an	an	DET
easat-2730	505	2	overview	overview	NOUN
easat-2730	505	3	.	.	PUNCT
easat-2730	506	1	molecules	molecule	NOUN
easat-2730	506	2	.	.	PUNCT
easat-2730	507	1	2018;23(12):3244	2018;23(12):3244	X
easat-2730	507	2	.	.	PUNCT
easat-2730	508	1	[	[	X
easat-2730	508	2	51	51	NUM
easat-2730	508	3	]	]	PUNCT
easat-2730	508	4	.	.	PUNCT
easat-2730	509	1	micheletta	micheletta	PROPN
easat-2730	509	2	,	,	PUNCT
easat-2730	509	3	f.	f.	PROPN
easat-2730	509	4	;	;	PUNCT
easat-2730	509	5	natoli	natoli	PROPN
easat-2730	509	6	,	,	PUNCT
easat-2730	509	7	s.	s.	PROPN
easat-2730	509	8	;	;	PUNCT
easat-2730	509	9	misuraca	misuraca	NOUN
easat-2730	509	10	,	,	PUNCT
easat-2730	509	11	m.	m.	NOUN
easat-2730	509	12	;	;	PUNCT
easat-2730	509	13	sbarigia	sbarigia	X
easat-2730	509	14	,	,	PUNCT
easat-2730	509	15	e.	e.	PROPN
easat-2730	509	16	;	;	PUNCT
easat-2730	509	17	and	and	CCONJ
easat-2730	509	18	diczfalusy	diczfalusy	PROPN
easat-2730	509	19	,	,	PUNCT
easat-2730	509	20	u.	u.	PROPN
easat-2730	509	21	i.	i.	PROPN
easat-2730	509	22	l.	l.	PROPN
easat-2730	509	23	vitamin	vitamin	PROPN
easat-2730	509	24	e	e	PROPN
easat-2730	509	25	supplementation	supplementation	NOUN
easat-2730	509	26	in	in	ADP
easat-2730	509	27	patients	patient	NOUN
easat-2730	509	28	with	with	ADP
easat-2730	509	29	carotid	carotid	NOUN
easat-2730	509	30	atherosclerosis	atherosclerosis	NOUN
easat-2730	509	31	:	:	PUNCT
easat-2730	509	32	reversal	reversal	NOUN
easat-2730	509	33	of	of	ADP
easat-2730	509	34	altered	altered	ADJ
easat-2730	509	35	oxidative	oxidative	ADJ
easat-2730	509	36	stress	stress	NOUN
easat-2730	509	37	status	status	NOUN
easat-2730	509	38	in	in	ADP
easat-2730	509	39	plasma	plasma	NOUN
easat-2730	509	40	but	but	CCONJ
easat-2730	509	41	not	not	PART
easat-2730	509	42	in	in	ADP
easat-2730	509	43	plaque	plaque	NOUN
easat-2730	509	44	.	.	PUNCT
easat-2730	510	1	arter	arter	NOUN
easat-2730	510	2	thromb	thromb	PROPN
easat-2730	510	3	vasc	vasc	PROPN
easat-2730	510	4	biol	biol	PROPN
easat-2730	510	5	.	.	PUNCT
easat-2730	511	1	2004;24:136–40	2004;24:136–40	X
easat-2730	511	2	.	.	PUNCT