id	sid	tid	token	lemma	pos
easat-3738	1	1	edelweiss	edelweiss	PROPN
easat-3738	1	2	applied	apply	VERB
easat-3738	1	3	science	science	NOUN
easat-3738	1	4	and	and	CCONJ
easat-3738	1	5	technology	technology	NOUN
easat-3738	1	6	issn	issn	PROPN
easat-3738	1	7	:	:	PUNCT
easat-3738	1	8	2576	2576	NUM
easat-3738	1	9	-	-	SYM
easat-3738	1	10	8484	8484	NUM
easat-3738	1	11	vol	vol	NOUN
easat-3738	1	12	.	.	PROPN
easat-3738	1	13	8	8	NUM
easat-3738	1	14	,	,	PUNCT
easat-3738	1	15	no	no	INTJ
easat-3738	1	16	.	.	NOUN
easat-3738	1	17	5	5	NUM
easat-3738	1	18	,	,	PUNCT
easat-3738	1	19	2536	2536	NUM
easat-3738	1	20	-	-	SYM
easat-3738	1	21	2541	2541	NUM
easat-3738	1	22	2024	2024	NUM
easat-3738	1	23	publisher	publisher	NOUN
easat-3738	1	24	:	:	PUNCT
easat-3738	1	25	learning	learn	VERB
easat-3738	1	26	gate	gate	NOUN
easat-3738	1	27	doi	doi	PROPN
easat-3738	1	28	:	:	PUNCT
easat-3738	1	29	10.55214/25768484.v8i6.3738	10.55214/25768484.v8i6.3738	NUM
easat-3738	1	30	©	©	PROPN
easat-3738	1	31	2024	2024	NUM
easat-3738	1	32	by	by	ADP
easat-3738	1	33	the	the	DET
easat-3738	1	34	authors	author	NOUN
easat-3738	1	35	;	;	PUNCT
easat-3738	1	36	licensee	licensee	PROPN
easat-3738	1	37	learning	learning	NOUN
easat-3738	1	38	gate	gate	NOUN
easat-3738	1	39	©	©	PROPN
easat-3738	1	40	2024	2024	NUM
easat-3738	1	41	by	by	ADP
easat-3738	1	42	the	the	DET
easat-3738	1	43	authors	author	NOUN
easat-3738	1	44	;	;	PUNCT
easat-3738	1	45	licensee	licensee	PROPN
easat-3738	1	46	learning	learn	VERB
easat-3738	1	47	gate	gate	NOUN
easat-3738	1	48	*	*	PUNCT
easat-3738	1	49	correspondence	correspondence	NOUN
easat-3738	1	50	:	:	PUNCT
easat-3738	1	51	ahmed.mohammed@nbu.edu.sa	ahmed.mohammed@nbu.edu.sa	PROPN
easat-3738	1	52	inflammatory	inflammatory	ADJ
easat-3738	1	53	immune	immune	ADJ
easat-3738	1	54	response	response	NOUN
easat-3738	1	55	and	and	CCONJ
easat-3738	1	56	its	its	PRON
easat-3738	1	57	key	key	ADJ
easat-3738	1	58	roles	role	NOUN
easat-3738	1	59	in	in	ADP
easat-3738	1	60	the	the	DET
easat-3738	1	61	process	process	NOUN
easat-3738	1	62	of	of	ADP
easat-3738	1	63	bone	bone	NOUN
easat-3738	1	64	fractures	fracture	NOUN
easat-3738	1	65	healing	heal	VERB
easat-3738	1	66	ahmad	ahmad	PROPN
easat-3738	1	67	m.	m.	PROPN
easat-3738	1	68	abdel	abdel	PROPN
easat-3738	1	69	-	-	PUNCT
easat-3738	1	70	mageed1	mageed1	PROPN
easat-3738	1	71	*	*	PROPN
easat-3738	1	72	,	,	PUNCT
easat-3738	1	73	abdellatif	abdellatif	NOUN
easat-3738	1	74	,	,	PUNCT
easat-3738	1	75	m.	m.	NOUN
easat-3738	1	76	m2	m2	PROPN
easat-3738	1	77	,	,	PUNCT
easat-3738	1	78	ali	ali	PROPN
easat-3738	1	79	y.	y.	PROPN
easat-3738	1	80	h1,3	h1,3	PROPN
easat-3738	1	81	,	,	PUNCT
easat-3738	1	82	intisar	intisar	PROPN
easat-3738	1	83	k.s2,3	k.s2,3	PROPN
easat-3738	1	84	,	,	PUNCT
easat-3738	1	85	ismail	ismail	PROPN
easat-3738	1	86	m.	m.	PROPN
easat-3738	1	87	a.	a.	PROPN
easat-3738	1	88	m.	m.	PROPN
easat-3738	1	89	shahhat1	shahhat1	PROPN
easat-3738	1	90	,	,	PUNCT
easat-3738	1	91	medhat	medhat	PROPN
easat-3738	1	92	ahmed	ahme	VERB
easat-3738	1	93	abu	abu	PROPN
easat-3738	1	94	-	-	PUNCT
easat-3738	1	95	tahon1,4	tahon1,4	PROPN
easat-3738	1	96	,	,	PUNCT
easat-3738	1	97	mohamed	mohamed	PROPN
easat-3738	1	98	a.	a.	PROPN
easat-3738	1	99	abdein5	abdein5	PROPN
easat-3738	1	100	,	,	PUNCT
easat-3738	1	101	mohammad	mohammad	PROPN
easat-3738	1	102	m.	m.	NOUN
easat-3738	1	103	aljameeli1	aljameeli1	PROPN
easat-3738	1	104	,	,	PUNCT
easat-3738	1	105	salma	salma	PROPN
easat-3738	1	106	yousif	yousif	PROPN
easat-3738	1	107	sidahmed	sidahme	VERB
easat-3738	1	108	elsheikh1	elsheikh1	PROPN
easat-3738	1	109	,	,	PUNCT
easat-3738	1	110	shereen	shereen	PROPN
easat-3738	1	111	ahmed	ahme	VERB
easat-3738	1	112	elwasefy6,7	elwasefy6,7	PROPN
easat-3738	1	113	,	,	PUNCT
easat-3738	1	114	sihem	sihem	PROPN
easat-3738	1	115	mahrouki2	mahrouki2	PROPN
easat-3738	1	116	,	,	PUNCT
easat-3738	1	117	zeinab	zeinab	PROPN
easat-3738	1	118	a.	a.	PROPN
easat-3738	1	119	ali8,9	ali8,9	PROPN
easat-3738	1	120	1department	1department	NUM
easat-3738	1	121	of	of	ADP
easat-3738	1	122	biological	biological	ADJ
easat-3738	1	123	sciences	science	NOUN
easat-3738	1	124	,	,	PUNCT
easat-3738	1	125	college	college	NOUN
easat-3738	1	126	of	of	ADP
easat-3738	1	127	science	science	NOUN
easat-3738	1	128	,	,	PUNCT
easat-3738	1	129	northern	northern	ADJ
easat-3738	1	130	border	border	NOUN
easat-3738	1	131	university	university	PROPN
easat-3738	1	132	,	,	PUNCT
easat-3738	1	133	arar	arar	PROPN
easat-3738	1	134	,	,	PUNCT
easat-3738	1	135	saudi	saudi	PROPN
easat-3738	1	136	arabia	arabia	PROPN
easat-3738	1	137	;	;	PUNCT
easat-3738	1	138	ahmed.mohammed@nbu.edu.sa	ahmed.mohammed@nbu.edu.sa	PROPN
easat-3738	1	139	,	,	PUNCT
easat-3738	1	140	ahmad1172@yahoo.com	ahmad1172@yahoo.com	X
easat-3738	2	1	(	(	PUNCT
easat-3738	2	2	a.m.a.m	a.m.a.m	PROPN
easat-3738	2	3	.	.	PROPN
easat-3738	2	4	)	)	PUNCT
easat-3738	2	5	.	.	PUNCT
easat-3738	3	1	2biology	2biology	NUM
easat-3738	3	2	department	department	NOUN
easat-3738	3	3	,	,	PUNCT
easat-3738	3	4	college	college	NOUN
easat-3738	3	5	of	of	ADP
easat-3738	3	6	science	science	NOUN
easat-3738	3	7	and	and	CCONJ
easat-3738	3	8	arts	art	NOUN
easat-3738	3	9	,	,	PUNCT
easat-3738	3	10	northern	northern	ADJ
easat-3738	3	11	border	border	NOUN
easat-3738	3	12	university	university	PROPN
easat-3738	3	13	,	,	PUNCT
easat-3738	3	14	rafha	rafha	PROPN
easat-3738	3	15	,	,	PUNCT
easat-3738	3	16	saudi	saudi	PROPN
easat-3738	3	17	arabia	arabia	PROPN
easat-3738	3	18	.	.	PUNCT
easat-3738	4	1	3department	3department	NUM
easat-3738	4	2	of	of	ADP
easat-3738	4	3	virology	virology	NOUN
easat-3738	4	4	,	,	PUNCT
easat-3738	4	5	central	central	ADJ
easat-3738	4	6	veterinary	veterinary	NOUN
easat-3738	4	7	,	,	PUNCT
easat-3738	4	8	research	research	NOUN
easat-3738	4	9	laboratory	laboratory	NOUN
easat-3738	4	10	p.	p.	PROPN
easat-3738	4	11	o.	o.	PROPN
easat-3738	4	12	box	box	PROPN
easat-3738	4	13	8067	8067	NUM
easat-3738	4	14	khartoum	khartoum	PROPN
easat-3738	4	15	,	,	PUNCT
easat-3738	4	16	sudan	sudan	PROPN
easat-3738	4	17	.	.	PUNCT
easat-3738	5	1	4biological	4biological	ADJ
easat-3738	5	2	and	and	CCONJ
easat-3738	5	3	geological	geological	ADJ
easat-3738	5	4	sciences	sciences	PROPN
easat-3738	5	5	department	department	NOUN
easat-3738	5	6	,	,	PUNCT
easat-3738	5	7	faculty	faculty	NOUN
easat-3738	5	8	of	of	ADP
easat-3738	5	9	education	education	NOUN
easat-3738	5	10	,	,	PUNCT
easat-3738	5	11	ain	ain	PROPN
easat-3738	5	12	shams	sham	NOUN
easat-3738	5	13	university	university	NOUN
easat-3738	5	14	.	.	PUNCT
easat-3738	6	1	5seeds	5seeds	NUM
easat-3738	6	2	development	development	NOUN
easat-3738	6	3	department	department	NOUN
easat-3738	6	4	,	,	PUNCT
easat-3738	6	5	el	el	PROPN
easat-3738	6	6	-	-	PUNCT
easat-3738	6	7	nada	nada	PROPN
easat-3738	6	8	misr	misr	PROPN
easat-3738	6	9	scientific	scientific	ADJ
easat-3738	6	10	research	research	NOUN
easat-3738	6	11	and	and	CCONJ
easat-3738	6	12	development	development	NOUN
easat-3738	6	13	projects	project	NOUN
easat-3738	6	14	,	,	PUNCT
easat-3738	6	15	mansoura	mansoura	PROPN
easat-3738	6	16	,	,	PUNCT
easat-3738	6	17	egypt	egypt	PROPN
easat-3738	6	18	6assistant	6assistant	NUM
easat-3738	6	19	professor	professor	NOUN
easat-3738	6	20	of	of	ADP
easat-3738	6	21	pediatric	pediatric	ADJ
easat-3738	6	22	nursing	nursing	NOUN
easat-3738	6	23	,	,	PUNCT
easat-3738	6	24	department	department	NOUN
easat-3738	6	25	of	of	ADP
easat-3738	6	26	nursing	nursing	NOUN
easat-3738	6	27	,	,	PUNCT
easat-3738	6	28	college	college	NOUN
easat-3738	6	29	of	of	ADP
easat-3738	6	30	applied	apply	VERB
easat-3738	6	31	medical	medical	ADJ
easat-3738	6	32	science	science	NOUN
easat-3738	6	33	,	,	PUNCT
easat-3738	6	34	jouf	jouf	PROPN
easat-3738	6	35	university	university	NOUN
easat-3738	6	36	.	.	PUNCT
easat-3738	7	1	7assistant	7assistant	NUM
easat-3738	7	2	professor	professor	NOUN
easat-3738	7	3	of	of	ADP
easat-3738	7	4	pediatric	pediatric	ADJ
easat-3738	7	5	nursing	nursing	NOUN
easat-3738	7	6	,	,	PUNCT
easat-3738	7	7	faculty	faculty	NOUN
easat-3738	7	8	of	of	ADP
easat-3738	7	9	nursing	nursing	NOUN
easat-3738	7	10	,	,	PUNCT
easat-3738	7	11	mansoura	mansoura	ADJ
easat-3738	7	12	university	university	NOUN
easat-3738	7	13	.	.	PUNCT
easat-3738	8	1	cairo	cairo	PROPN
easat-3738	8	2	,	,	PUNCT
easat-3738	8	3	egypt	egypt	PROPN
easat-3738	8	4	.	.	PUNCT
easat-3738	9	1	8department	8department	NUM
easat-3738	9	2	of	of	ADP
easat-3738	9	3	physical	physical	ADJ
easat-3738	9	4	therapy	therapy	NOUN
easat-3738	9	5	and	and	CCONJ
easat-3738	9	6	health	health	NOUN
easat-3738	9	7	rehabilitation	rehabilitation	NOUN
easat-3738	9	8	,	,	PUNCT
easat-3738	9	9	college	college	NOUN
easat-3738	9	10	of	of	ADP
easat-3738	9	11	applied	apply	VERB
easat-3738	9	12	medical	medical	ADJ
easat-3738	9	13	science	science	NOUN
easat-3738	9	14	,	,	PUNCT
easat-3738	9	15	jouf	jouf	PROPN
easat-3738	9	16	university	university	PROPN
easat-3738	9	17	,	,	PUNCT
easat-3738	9	18	saudi	saudi	PROPN
easat-3738	9	19	arabia	arabia	PROPN
easat-3738	9	20	.	.	PUNCT
easat-3738	10	1	9department	9department	NUM
easat-3738	10	2	of	of	ADP
easat-3738	10	3	physical	physical	ADJ
easat-3738	10	4	therapy	therapy	NOUN
easat-3738	10	5	for	for	ADP
easat-3738	10	6	surgery	surgery	NOUN
easat-3738	10	7	,	,	PUNCT
easat-3738	10	8	faculty	faculty	NOUN
easat-3738	10	9	of	of	ADP
easat-3738	10	10	physical	physical	ADJ
easat-3738	10	11	therapy	therapy	NOUN
easat-3738	10	12	,	,	PUNCT
easat-3738	10	13	cairo	cairo	PROPN
easat-3738	10	14	university	university	PROPN
easat-3738	10	15	,	,	PUNCT
easat-3738	10	16	cairo	cairo	PROPN
easat-3738	10	17	,	,	PUNCT
easat-3738	10	18	egypt	egypt	PROPN
easat-3738	10	19	.	.	PUNCT
easat-3738	11	1	abstract	abstract	ADJ
easat-3738	11	2	:	:	PUNCT
easat-3738	11	3	bone	bone	NOUN
easat-3738	11	4	fractures	fracture	NOUN
easat-3738	11	5	,	,	PUNCT
easat-3738	11	6	which	which	PRON
easat-3738	11	7	represent	represent	VERB
easat-3738	11	8	2	2	NUM
easat-3738	11	9	%	%	NOUN
easat-3738	11	10	5	5	NUM
easat-3738	11	11	%	%	NOUN
easat-3738	11	12	of	of	ADP
easat-3738	11	13	adults	adult	NOUN
easat-3738	11	14	annually	annually	ADV
easat-3738	11	15	,	,	PUNCT
easat-3738	11	16	are	be	AUX
easat-3738	11	17	considered	consider	VERB
easat-3738	11	18	a	a	DET
easat-3738	11	19	significant	significant	ADJ
easat-3738	11	20	health	health	NOUN
easat-3738	11	21	concern	concern	NOUN
easat-3738	11	22	,	,	PUNCT
easat-3738	11	23	particularly	particularly	ADV
easat-3738	11	24	as	as	SCONJ
easat-3738	11	25	their	their	PRON
easat-3738	11	26	incidence	incidence	NOUN
easat-3738	11	27	has	have	AUX
easat-3738	11	28	recently	recently	ADV
easat-3738	11	29	increased	increase	VERB
easat-3738	11	30	.	.	PUNCT
easat-3738	12	1	bones	bone	NOUN
easat-3738	12	2	are	be	AUX
easat-3738	12	3	composed	compose	VERB
easat-3738	12	4	of	of	ADP
easat-3738	12	5	minerals	mineral	NOUN
easat-3738	12	6	such	such	ADJ
easat-3738	12	7	as	as	ADP
easat-3738	12	8	calcium	calcium	NOUN
easat-3738	12	9	and	and	CCONJ
easat-3738	12	10	phosphate	phosphate	NOUN
easat-3738	12	11	,	,	PUNCT
easat-3738	12	12	and	and	CCONJ
easat-3738	12	13	organic	organic	ADJ
easat-3738	12	14	components	component	NOUN
easat-3738	12	15	like	like	ADP
easat-3738	12	16	type	type	NOUN
easat-3738	12	17	i	i	PRON
easat-3738	12	18	collagen	collagen	VERB
easat-3738	12	19	,	,	PUNCT
easat-3738	12	20	provide	provide	VERB
easat-3738	12	21	structural	structural	ADJ
easat-3738	12	22	integrity	integrity	NOUN
easat-3738	12	23	and	and	CCONJ
easat-3738	12	24	strength	strength	NOUN
easat-3738	12	25	.	.	PUNCT
easat-3738	13	1	the	the	DET
easat-3738	13	2	periosteum	periosteum	NOUN
easat-3738	13	3	plays	play	VERB
easat-3738	13	4	a	a	DET
easat-3738	13	5	vital	vital	ADJ
easat-3738	13	6	role	role	NOUN
easat-3738	13	7	in	in	ADP
easat-3738	13	8	bone	bone	NOUN
easat-3738	13	9	healing	healing	NOUN
easat-3738	13	10	,	,	PUNCT
easat-3738	13	11	with	with	ADP
easat-3738	13	12	children	child	NOUN
easat-3738	13	13	's	's	PART
easat-3738	13	14	thicker	thick	ADJ
easat-3738	13	15	periosteum	periosteum	NOUN
easat-3738	13	16	contributing	contribute	VERB
easat-3738	13	17	to	to	ADP
easat-3738	13	18	faster	fast	ADJ
easat-3738	13	19	recovery	recovery	NOUN
easat-3738	13	20	compared	compare	VERB
easat-3738	13	21	to	to	ADP
easat-3738	13	22	adults	adult	NOUN
easat-3738	13	23	.	.	PUNCT
easat-3738	14	1	this	this	DET
easat-3738	14	2	review	review	NOUN
easat-3738	14	3	emphasizes	emphasize	VERB
easat-3738	14	4	the	the	DET
easat-3738	14	5	critical	critical	ADJ
easat-3738	14	6	role	role	NOUN
easat-3738	14	7	of	of	ADP
easat-3738	14	8	the	the	DET
easat-3738	14	9	immune	immune	ADJ
easat-3738	14	10	system	system	NOUN
easat-3738	14	11	in	in	ADP
easat-3738	14	12	bone	bone	NOUN
easat-3738	14	13	fracture	fracture	NOUN
easat-3738	14	14	healing	healing	NOUN
easat-3738	14	15	,	,	PUNCT
easat-3738	14	16	highlighting	highlight	VERB
easat-3738	14	17	the	the	DET
easat-3738	14	18	inflammatory	inflammatory	ADJ
easat-3738	14	19	response	response	NOUN
easat-3738	14	20	as	as	ADP
easat-3738	14	21	a	a	DET
easat-3738	14	22	key	key	ADJ
easat-3738	14	23	factor	factor	NOUN
easat-3738	14	24	in	in	ADP
easat-3738	14	25	bone	bone	NOUN
easat-3738	14	26	healing	healing	NOUN
easat-3738	14	27	.	.	PUNCT
easat-3738	15	1	immediately	immediately	ADV
easat-3738	15	2	after	after	ADP
easat-3738	15	3	the	the	DET
easat-3738	15	4	occurrence	occurrence	NOUN
easat-3738	15	5	of	of	ADP
easat-3738	15	6	a	a	DET
easat-3738	15	7	fracture	fracture	NOUN
easat-3738	15	8	,	,	PUNCT
easat-3738	15	9	immune	immune	ADJ
easat-3738	15	10	cells	cell	NOUN
easat-3738	15	11	are	be	AUX
easat-3738	15	12	recruited	recruit	VERB
easat-3738	15	13	to	to	ADP
easat-3738	15	14	the	the	DET
easat-3738	15	15	site	site	NOUN
easat-3738	15	16	of	of	ADP
easat-3738	15	17	the	the	DET
easat-3738	15	18	fracture	fracture	NOUN
easat-3738	15	19	,	,	PUNCT
easat-3738	15	20	initiating	initiate	VERB
easat-3738	15	21	a	a	DET
easat-3738	15	22	cascade	cascade	NOUN
easat-3738	15	23	of	of	ADP
easat-3738	15	24	healing	healing	NOUN
easat-3738	15	25	processes	process	NOUN
easat-3738	15	26	that	that	PRON
easat-3738	15	27	include	include	VERB
easat-3738	15	28	angiogenesis	angiogenesis	NOUN
easat-3738	15	29	and	and	CCONJ
easat-3738	15	30	tissue	tissue	NOUN
easat-3738	15	31	repair	repair	NOUN
easat-3738	15	32	scenarios	scenario	NOUN
easat-3738	15	33	.	.	PUNCT
easat-3738	16	1	the	the	DET
easat-3738	16	2	healing	healing	NOUN
easat-3738	16	3	process	process	NOUN
easat-3738	16	4	is	be	AUX
easat-3738	16	5	classified	classify	VERB
easat-3738	16	6	into	into	ADP
easat-3738	16	7	primary	primary	ADJ
easat-3738	16	8	and	and	CCONJ
easat-3738	16	9	secondary	secondary	ADJ
easat-3738	16	10	healing	healing	NOUN
easat-3738	16	11	,	,	PUNCT
easat-3738	16	12	each	each	PRON
easat-3738	16	13	with	with	ADP
easat-3738	16	14	distinct	distinct	ADJ
easat-3738	16	15	mechanisms	mechanism	NOUN
easat-3738	16	16	.	.	PUNCT
easat-3738	17	1	factors	factor	NOUN
easat-3738	17	2	influencing	influence	VERB
easat-3738	17	3	healing	healing	NOUN
easat-3738	17	4	include	include	VERB
easat-3738	17	5	fracture	fracture	NOUN
easat-3738	17	6	location	location	NOUN
easat-3738	17	7	,	,	PUNCT
easat-3738	17	8	patient	patient	ADJ
easat-3738	17	9	age	age	NOUN
easat-3738	17	10	,	,	PUNCT
easat-3738	17	11	physical	physical	ADJ
easat-3738	17	12	activity	activity	NOUN
easat-3738	17	13	levels	level	NOUN
easat-3738	17	14	,	,	PUNCT
easat-3738	17	15	medical	medical	ADJ
easat-3738	17	16	conditions	condition	NOUN
easat-3738	17	17	,	,	PUNCT
easat-3738	17	18	medication	medication	NOUN
easat-3738	17	19	use	use	NOUN
easat-3738	17	20	,	,	PUNCT
easat-3738	17	21	smoking	smoking	NOUN
easat-3738	17	22	,	,	PUNCT
easat-3738	17	23	and	and	CCONJ
easat-3738	17	24	the	the	DET
easat-3738	17	25	biomechanical	biomechanical	ADJ
easat-3738	17	26	environment	environment	NOUN
easat-3738	17	27	.	.	PUNCT
easat-3738	18	1	the	the	DET
easat-3738	18	2	healing	healing	NOUN
easat-3738	18	3	phases	phase	NOUN
easat-3738	18	4	—	—	PUNCT
easat-3738	18	5	inflammatory	inflammatory	ADJ
easat-3738	18	6	,	,	PUNCT
easat-3738	18	7	repair	repair	NOUN
easat-3738	18	8	,	,	PUNCT
easat-3738	18	9	and	and	CCONJ
easat-3738	18	10	remodeling	remodeling	NOUN
easat-3738	18	11	—	—	PUNCT
easat-3738	18	12	are	be	AUX
easat-3738	18	13	regulated	regulate	VERB
easat-3738	18	14	by	by	ADP
easat-3738	18	15	the	the	DET
easat-3738	18	16	immune	immune	ADJ
easat-3738	18	17	cells	cell	NOUN
easat-3738	18	18	,	,	PUNCT
easat-3738	18	19	particularly	particularly	ADV
easat-3738	18	20	macrophages	macrophage	NOUN
easat-3738	18	21	and	and	CCONJ
easat-3738	18	22	t	t	NOUN
easat-3738	18	23	-	-	PUNCT
easat-3738	18	24	cells	cell	NOUN
easat-3738	18	25	,	,	PUNCT
easat-3738	18	26	which	which	PRON
easat-3738	18	27	can	can	AUX
easat-3738	18	28	either	either	CCONJ
easat-3738	18	29	facilitate	facilitate	VERB
easat-3738	18	30	or	or	CCONJ
easat-3738	18	31	hinder	hinder	NOUN
easat-3738	18	32	recovery	recovery	NOUN
easat-3738	18	33	.	.	PUNCT
easat-3738	19	1	understanding	understand	VERB
easat-3738	19	2	the	the	DET
easat-3738	19	3	immune	immune	ADJ
easat-3738	19	4	response	response	NOUN
easat-3738	19	5	is	be	AUX
easat-3738	19	6	essential	essential	ADJ
easat-3738	19	7	to	to	ADP
easat-3738	19	8	developing	develop	VERB
easat-3738	19	9	effective	effective	ADJ
easat-3738	19	10	therapeutic	therapeutic	ADJ
easat-3738	19	11	strategies	strategy	NOUN
easat-3738	19	12	for	for	ADP
easat-3738	19	13	the	the	DET
easat-3738	19	14	healing	healing	NOUN
easat-3738	19	15	of	of	ADP
easat-3738	19	16	the	the	DET
easat-3738	19	17	bone	bone	NOUN
easat-3738	19	18	structures	structure	NOUN
easat-3738	19	19	.	.	PUNCT
easat-3738	20	1	keywords	keyword	NOUN
easat-3738	20	2	:	:	PUNCT
easat-3738	20	3	bone	bone	NOUN
easat-3738	20	4	fractures	fracture	NOUN
easat-3738	20	5	,	,	PUNCT
easat-3738	20	6	bone	bone	NOUN
easat-3738	20	7	healing	healing	NOUN
easat-3738	20	8	,	,	PUNCT
easat-3738	20	9	immune	immune	ADJ
easat-3738	20	10	response	response	NOUN
easat-3738	20	11	,	,	PUNCT
easat-3738	20	12	inflammation	inflammation	NOUN
easat-3738	20	13	.	.	PUNCT
easat-3738	21	1	1	1	X
easat-3738	21	2	.	.	X
easat-3738	21	3	introduction	introduction	NOUN
easat-3738	21	4	bones	bone	NOUN
easat-3738	21	5	represent	represent	VERB
easat-3738	21	6	15	15	NUM
easat-3738	21	7	%	%	NOUN
easat-3738	21	8	of	of	ADP
easat-3738	21	9	the	the	DET
easat-3738	21	10	total	total	ADJ
easat-3738	21	11	body	body	NOUN
easat-3738	21	12	weight	weight	NOUN
easat-3738	21	13	of	of	ADP
easat-3738	21	14	an	an	DET
easat-3738	21	15	adult	adult	NOUN
easat-3738	21	16	.	.	PUNCT
easat-3738	22	1	the	the	DET
easat-3738	22	2	percentage	percentage	NOUN
easat-3738	22	3	of	of	ADP
easat-3738	22	4	the	the	DET
easat-3738	22	5	fracture	fracture	NOUN
easat-3738	22	6	ranges	range	VERB
easat-3738	22	7	from	from	ADP
easat-3738	22	8	2	2	NUM
easat-3738	22	9	%	%	NOUN
easat-3738	22	10	to	to	PART
easat-3738	22	11	5	5	NUM
easat-3738	22	12	%	%	NOUN
easat-3738	22	13	per	per	ADP
easat-3738	22	14	year	year	NOUN
easat-3738	22	15	.	.	PUNCT
easat-3738	23	1	recently	recently	ADV
easat-3738	23	2	,	,	PUNCT
easat-3738	23	3	significant	significant	ADJ
easat-3738	23	4	increase	increase	NOUN
easat-3738	23	5	in	in	ADP
easat-3738	23	6	the	the	DET
easat-3738	23	7	fracture	fracture	NOUN
easat-3738	23	8	percentage	percentage	NOUN
easat-3738	23	9	was	be	AUX
easat-3738	23	10	obviously	obviously	ADV
easat-3738	23	11	noticed	notice	VERB
easat-3738	23	12	[	[	X
easat-3738	23	13	2	2	NUM
easat-3738	23	14	,	,	PUNCT
easat-3738	23	15	3	3	NUM
easat-3738	23	16	]	]	PUNCT
easat-3738	23	17	.	.	PUNCT
easat-3738	24	1	bones	bone	NOUN
easat-3738	24	2	are	be	AUX
easat-3738	24	3	a	a	DET
easat-3738	24	4	mixture	mixture	NOUN
easat-3738	24	5	of	of	ADP
easat-3738	24	6	minerals	mineral	NOUN
easat-3738	24	7	and	and	CCONJ
easat-3738	24	8	organic	organic	ADJ
easat-3738	24	9	substances	substance	NOUN
easat-3738	24	10	;	;	PUNCT
easat-3738	24	11	the	the	DET
easat-3738	24	12	minerals	mineral	NOUN
easat-3738	24	13	include	include	VERB
easat-3738	24	14	calcium	calcium	NOUN
easat-3738	24	15	,	,	PUNCT
easat-3738	24	16	phosphate	phosphate	NOUN
easat-3738	24	17	,	,	PUNCT
easat-3738	24	18	and	and	CCONJ
easat-3738	24	19	hydroxyl	hydroxyl	NOUN
easat-3738	24	20	ions	ion	NOUN
easat-3738	24	21	,	,	PUNCT
easat-3738	24	22	which	which	PRON
easat-3738	24	23	are	be	AUX
easat-3738	24	24	incorporated	incorporate	VERB
easat-3738	24	25	into	into	ADP
easat-3738	24	26	a	a	DET
easat-3738	24	27	compound	compound	NOUN
easat-3738	24	28	called	call	VERB
easat-3738	24	29	hydroxyapatite	hydroxyapatite	NOUN
easat-3738	24	30	(	(	PUNCT
easat-3738	24	31	ca5(po4)3(oh	ca5(po4)3(oh	NOUN
easat-3738	24	32	)	)	PUNCT
easat-3738	24	33	)	)	PUNCT
easat-3738	24	34	.	.	PUNCT
easat-3738	25	1	this	this	DET
easat-3738	25	2	skeletal	skeletal	ADJ
easat-3738	25	3	structure	structure	NOUN
easat-3738	25	4	provides	provide	VERB
easat-3738	25	5	the	the	DET
easat-3738	25	6	strength	strength	NOUN
easat-3738	25	7	,	,	PUNCT
easat-3738	25	8	hardness	hardness	NOUN
easat-3738	25	9	,	,	PUNCT
easat-3738	25	10	and	and	CCONJ
easat-3738	25	11	rigidity	rigidity	NOUN
easat-3738	25	12	of	of	ADP
easat-3738	25	13	bone	bone	NOUN
easat-3738	25	14	.	.	PUNCT
easat-3738	26	1	the	the	DET
easat-3738	26	2	organic	organic	ADJ
easat-3738	26	3	or	or	CCONJ
easat-3738	26	4	protein	protein	NOUN
easat-3738	26	5	component	component	NOUN
easat-3738	26	6	consists	consist	VERB
easat-3738	26	7	of	of	ADP
easat-3738	26	8	type	type	NOUN
easat-3738	26	9	i	i	PRON
easat-3738	26	10	collagen	collagen	NOUN
easat-3738	26	11	,	,	PUNCT
easat-3738	26	12	which	which	PRON
easat-3738	26	13	provides	provide	VERB
easat-3738	26	14	elasticity	elasticity	NOUN
easat-3738	26	15	and	and	CCONJ
easat-3738	26	16	tensile	tensile	NOUN
easat-3738	26	17	strength	strength	NOUN
easat-3738	26	18	.	.	PUNCT
easat-3738	27	1	the	the	DET
easat-3738	27	2	periosteum	periosteum	NOUN
easat-3738	27	3	,	,	PUNCT
easat-3738	27	4	which	which	PRON
easat-3738	27	5	is	be	AUX
easat-3738	27	6	the	the	DET
easat-3738	27	7	outer	outer	ADJ
easat-3738	27	8	layer	layer	NOUN
easat-3738	27	9	of	of	ADP
easat-3738	27	10	bone	bone	NOUN
easat-3738	27	11	,	,	PUNCT
easat-3738	27	12	provides	provide	VERB
easat-3738	27	13	blood	blood	NOUN
easat-3738	27	14	supply	supply	NOUN
easat-3738	27	15	and	and	CCONJ
easat-3738	27	16	plays	play	VERB
easat-3738	27	17	a	a	DET
easat-3738	27	18	crucial	crucial	ADJ
easat-3738	27	19	role	role	NOUN
easat-3738	27	20	in	in	ADP
easat-3738	27	21	bone	bone	NOUN
easat-3738	27	22	healing	healing	NOUN
easat-3738	27	23	.	.	PUNCT
easat-3738	28	1	children	child	NOUN
easat-3738	28	2	's	's	PART
easat-3738	28	3	periosteum	periosteum	NOUN
easat-3738	28	4	is	be	AUX
easat-3738	28	5	thicker	thick	ADJ
easat-3738	28	6	and	and	CCONJ
easat-3738	28	7	stronger	strong	ADJ
easat-3738	28	8	than	than	ADP
easat-3738	28	9	that	that	PRON
easat-3738	28	10	of	of	ADP
easat-3738	28	11	adults	adult	NOUN
easat-3738	28	12	,	,	PUNCT
easat-3738	28	13	which	which	PRON
easat-3738	28	14	explains	explain	VERB
easat-3738	28	15	reason	reason	NOUN
easat-3738	28	16	why	why	SCONJ
easat-3738	28	17	bone	bone	NOUN
easat-3738	28	18	healing	healing	NOUN
easat-3738	28	19	in	in	ADP
easat-3738	28	20	children	child	NOUN
easat-3738	28	21	is	be	AUX
easat-3738	28	22	faster	fast	ADJ
easat-3738	28	23	than	than	ADP
easat-3738	28	24	adults[4	adults[4	PROPN
easat-3738	28	25	,	,	PUNCT
easat-3738	28	26	5	5	NUM
easat-3738	28	27	]	]	PUNCT
easat-3738	28	28	.	.	PUNCT
easat-3738	29	1	as	as	ADP
easat-3738	29	2	hard	hard	ADJ
easat-3738	29	3	and	and	CCONJ
easat-3738	29	4	rigid	rigid	ADJ
easat-3738	29	5	tissue	tissue	NOUN
easat-3738	29	6	lacking	lack	VERB
easat-3738	29	7	elasticity	elasticity	NOUN
easat-3738	29	8	,	,	PUNCT
easat-3738	29	9	bones	bone	NOUN
easat-3738	29	10	may	may	AUX
easat-3738	29	11	be	be	AUX
easat-3738	29	12	subjected	subject	VERB
easat-3738	29	13	to	to	ADP
easat-3738	29	14	fracture	fracture	NOUN
easat-3738	29	15	,	,	PUNCT
easat-3738	29	16	which	which	PRON
easat-3738	29	17	must	must	AUX
easat-3738	29	18	be	be	AUX
easat-3738	29	19	repaired	repair	VERB
easat-3738	29	20	to	to	PART
easat-3738	29	21	perform	perform	VERB
easat-3738	29	22	the	the	DET
easat-3738	29	23	normal	normal	ADJ
easat-3738	29	24	functions	function	NOUN
easat-3738	29	25	of	of	ADP
easat-3738	29	26	the	the	DET
easat-3738	29	27	bones	bone	NOUN
easat-3738	29	28	.	.	PUNCT
easat-3738	30	1	2537	2537	NUM
easat-3738	30	2	edelweiss	edelweiss	PROPN
easat-3738	30	3	applied	apply	VERB
easat-3738	30	4	science	science	NOUN
easat-3738	30	5	and	and	CCONJ
easat-3738	30	6	technology	technology	NOUN
easat-3738	30	7	issn	issn	PROPN
easat-3738	30	8	:	:	PUNCT
easat-3738	30	9	2576	2576	NUM
easat-3738	30	10	-	-	SYM
easat-3738	30	11	8484	8484	NUM
easat-3738	30	12	vol	vol	NOUN
easat-3738	30	13	.	.	PROPN
easat-3738	30	14	8	8	NUM
easat-3738	30	15	,	,	PUNCT
easat-3738	30	16	no	no	INTJ
easat-3738	30	17	.	.	NOUN
easat-3738	30	18	5	5	NUM
easat-3738	30	19	:	:	SYM
easat-3738	30	20	2536	2536	NUM
easat-3738	30	21	-	-	SYM
easat-3738	30	22	2541	2541	NUM
easat-3738	30	23	,	,	PUNCT
easat-3738	30	24	2024	2024	NUM
easat-3738	30	25	doi	doi	NOUN
easat-3738	30	26	:	:	PUNCT
easat-3738	30	27	10.55214/25768484.v8i6.3738	10.55214/25768484.v8i6.3738	NUM
easat-3738	30	28	©	©	NOUN
easat-3738	30	29	2024	2024	NUM
easat-3738	30	30	by	by	ADP
easat-3738	30	31	the	the	DET
easat-3738	30	32	authors	author	NOUN
easat-3738	30	33	;	;	PUNCT
easat-3738	30	34	licensee	licensee	PROPN
easat-3738	30	35	learning	learning	NOUN
easat-3738	30	36	gate	gate	VERB
easat-3738	30	37	the	the	DET
easat-3738	30	38	immune	immune	ADJ
easat-3738	30	39	system	system	NOUN
easat-3738	30	40	has	have	VERB
easat-3738	30	41	a	a	DET
easat-3738	30	42	crucial	crucial	ADJ
easat-3738	30	43	role	role	NOUN
easat-3738	30	44	in	in	ADP
easat-3738	30	45	the	the	DET
easat-3738	30	46	process	process	NOUN
easat-3738	30	47	of	of	ADP
easat-3738	30	48	bone	bone	NOUN
easat-3738	30	49	fracture	fracture	NOUN
easat-3738	30	50	healing	healing	NOUN
easat-3738	30	51	.	.	PUNCT
easat-3738	31	1	the	the	DET
easat-3738	31	2	body	body	NOUN
easat-3738	31	3	initiates	initiate	VERB
easat-3738	31	4	a	a	DET
easat-3738	31	5	complex	complex	ADJ
easat-3738	31	6	healing	healing	NOUN
easat-3738	31	7	process	process	NOUN
easat-3738	31	8	just	just	ADV
easat-3738	31	9	after	after	SCONJ
easat-3738	31	10	the	the	DET
easat-3738	31	11	bone	bone	NOUN
easat-3738	31	12	is	be	AUX
easat-3738	31	13	fractured	fractured	ADJ
easat-3738	31	14	,	,	PUNCT
easat-3738	31	15	such	such	ADJ
easat-3738	31	16	process	process	NOUN
easat-3738	31	17	includes	include	VERB
easat-3738	31	18	several	several	ADJ
easat-3738	31	19	stages	stage	NOUN
easat-3738	31	20	.	.	PUNCT
easat-3738	32	1	the	the	DET
easat-3738	32	2	immune	immune	ADJ
easat-3738	32	3	system	system	NOUN
easat-3738	32	4	is	be	AUX
easat-3738	32	5	actively	actively	ADV
easat-3738	32	6	incorporated	incorporate	VERB
easat-3738	32	7	in	in	ADP
easat-3738	32	8	each	each	PRON
easat-3738	32	9	of	of	ADP
easat-3738	32	10	these	these	DET
easat-3738	32	11	stages	stage	NOUN
easat-3738	32	12	.	.	PUNCT
easat-3738	33	1	the	the	DET
easat-3738	33	2	current	current	ADJ
easat-3738	33	3	review	review	NOUN
easat-3738	33	4	aimed	aim	VERB
easat-3738	33	5	to	to	PART
easat-3738	33	6	highlight	highlight	VERB
easat-3738	33	7	the	the	DET
easat-3738	33	8	role	role	NOUN
easat-3738	33	9	of	of	ADP
easat-3738	33	10	the	the	DET
easat-3738	33	11	inflammatory	inflammatory	ADJ
easat-3738	33	12	immune	immune	ADJ
easat-3738	33	13	response	response	NOUN
easat-3738	33	14	mediated	mediate	VERB
easat-3738	33	15	by	by	ADP
easat-3738	33	16	the	the	DET
easat-3738	33	17	presence	presence	NOUN
easat-3738	33	18	of	of	ADP
easat-3738	33	19	inflammation	inflammation	NOUN
easat-3738	33	20	and	and	CCONJ
easat-3738	33	21	cellular	cellular	ADJ
easat-3738	33	22	responses	response	NOUN
easat-3738	33	23	as	as	ADP
easat-3738	33	24	critical	critical	ADJ
easat-3738	33	25	factors	factor	NOUN
easat-3738	33	26	in	in	ADP
easat-3738	33	27	the	the	DET
easat-3738	33	28	process	process	NOUN
easat-3738	33	29	of	of	ADP
easat-3738	33	30	fractured	fractured	ADJ
easat-3738	33	31	bone	bone	NOUN
easat-3738	33	32	healing	healing	NOUN
easat-3738	33	33	.	.	PUNCT
easat-3738	34	1	when	when	SCONJ
easat-3738	34	2	the	the	DET
easat-3738	34	3	bone	bone	NOUN
easat-3738	34	4	is	be	AUX
easat-3738	34	5	injured	injure	VERB
easat-3738	34	6	and	and	CCONJ
easat-3738	34	7	fractured	fracture	VERB
easat-3738	34	8	,	,	PUNCT
easat-3738	34	9	the	the	DET
easat-3738	34	10	cellular	cellular	ADJ
easat-3738	34	11	inflammatory	inflammatory	ADJ
easat-3738	34	12	response	response	NOUN
easat-3738	34	13	is	be	AUX
easat-3738	34	14	triggered	trigger	VERB
easat-3738	34	15	by	by	ADP
easat-3738	34	16	recruiting	recruiting	NOUN
easat-3738	34	17	and	and	CCONJ
easat-3738	34	18	accumulation	accumulation	NOUN
easat-3738	34	19	of	of	ADP
easat-3738	34	20	the	the	DET
easat-3738	34	21	immune	immune	ADJ
easat-3738	34	22	cells	cell	NOUN
easat-3738	34	23	at	at	ADP
easat-3738	34	24	the	the	DET
easat-3738	34	25	fracture	fracture	PROPN
easat-3738	34	26	site	site	NOUN
easat-3738	34	27	.	.	PUNCT
easat-3738	35	1	those	those	DET
easat-3738	35	2	cells	cell	NOUN
easat-3738	35	3	are	be	AUX
easat-3738	35	4	activated	activate	VERB
easat-3738	35	5	and	and	CCONJ
easat-3738	35	6	secrete	secrete	VERB
easat-3738	35	7	a	a	DET
easat-3738	35	8	variety	variety	NOUN
easat-3738	35	9	of	of	ADP
easat-3738	35	10	factors	factor	NOUN
easat-3738	35	11	including	include	VERB
easat-3738	35	12	inflammatory	inflammatory	ADJ
easat-3738	35	13	molecules	molecule	NOUN
easat-3738	35	14	.	.	PUNCT
easat-3738	36	1	inflammatory	inflammatory	ADJ
easat-3738	36	2	response	response	NOUN
easat-3738	36	3	is	be	AUX
easat-3738	36	4	essential	essential	ADJ
easat-3738	36	5	to	to	PART
easat-3738	36	6	obtain	obtain	VERB
easat-3738	36	7	normal	normal	ADJ
easat-3738	36	8	healing	healing	NOUN
easat-3738	36	9	of	of	ADP
easat-3738	36	10	the	the	DET
easat-3738	36	11	fractured	fractured	ADJ
easat-3738	36	12	bone	bone	NOUN
easat-3738	36	13	through	through	ADP
easat-3738	36	14	the	the	DET
easat-3738	36	15	process	process	NOUN
easat-3738	36	16	of	of	ADP
easat-3738	36	17	angiogenesis	angiogenesis	NOUN
easat-3738	36	18	of	of	ADP
easat-3738	36	19	the	the	DET
easat-3738	36	20	surrounding	surround	VERB
easat-3738	36	21	blood	blood	NOUN
easat-3738	36	22	vasculature	vasculature	NOUN
easat-3738	36	23	and	and	CCONJ
easat-3738	36	24	repair	repair	NOUN
easat-3738	36	25	of	of	ADP
easat-3738	36	26	the	the	DET
easat-3738	36	27	surrounding	surround	VERB
easat-3738	36	28	injured	injure	VERB
easat-3738	36	29	tissues	tissue	NOUN
easat-3738	36	30	until	until	SCONJ
easat-3738	36	31	new	new	ADJ
easat-3738	36	32	bone	bone	NOUN
easat-3738	36	33	is	be	AUX
easat-3738	36	34	formed	form	VERB
easat-3738	36	35	.	.	PUNCT
easat-3738	37	1	this	this	DET
easat-3738	37	2	strong	strong	ADJ
easat-3738	37	3	inflammatory	inflammatory	ADJ
easat-3738	37	4	action	action	NOUN
easat-3738	37	5	is	be	AUX
easat-3738	37	6	required	require	VERB
easat-3738	37	7	to	to	PART
easat-3738	37	8	achieve	achieve	VERB
easat-3738	37	9	normal	normal	ADJ
easat-3738	37	10	healing	healing	NOUN
easat-3738	37	11	through	through	ADP
easat-3738	37	12	angiogenesis	angiogenesis	NOUN
easat-3738	37	13	of	of	ADP
easat-3738	37	14	new	new	ADJ
easat-3738	37	15	blood	blood	NOUN
easat-3738	37	16	vessels	vessel	NOUN
easat-3738	37	17	,	,	PUNCT
easat-3738	37	18	repair	repair	NOUN
easat-3738	37	19	of	of	ADP
easat-3738	37	20	the	the	DET
easat-3738	37	21	surrounding	surround	VERB
easat-3738	37	22	injured	injured	ADJ
easat-3738	37	23	tissue	tissue	NOUN
easat-3738	37	24	until	until	SCONJ
easat-3738	37	25	remodeling	remodeling	NOUN
easat-3738	37	26	is	be	AUX
easat-3738	37	27	completely	completely	ADV
easat-3738	37	28	achieved	achieve	VERB
easat-3738	37	29	[	[	PUNCT
easat-3738	37	30	6	6	NUM
easat-3738	37	31	-	-	SYM
easat-3738	37	32	9	9	NUM
easat-3738	37	33	]	]	PUNCT
easat-3738	37	34	.	.	PUNCT
easat-3738	38	1	although	although	SCONJ
easat-3738	38	2	the	the	DET
easat-3738	38	3	immune	immune	ADJ
easat-3738	38	4	response	response	NOUN
easat-3738	38	5	is	be	AUX
easat-3738	38	6	short	short	ADV
easat-3738	38	7	-	-	PUNCT
easat-3738	38	8	lived	live	VERB
easat-3738	38	9	,	,	PUNCT
easat-3738	38	10	the	the	DET
easat-3738	38	11	effects	effect	NOUN
easat-3738	38	12	of	of	ADP
easat-3738	38	13	the	the	DET
easat-3738	38	14	recruited	recruit	VERB
easat-3738	38	15	immune	immune	ADJ
easat-3738	38	16	cells	cell	NOUN
easat-3738	38	17	extend	extend	VERB
easat-3738	38	18	beyond	beyond	ADP
easat-3738	38	19	the	the	DET
easat-3738	38	20	early	early	ADJ
easat-3738	38	21	stages	stage	NOUN
easat-3738	38	22	of	of	ADP
easat-3738	38	23	fracture	fracture	ADJ
easat-3738	38	24	healing	healing	NOUN
easat-3738	38	25	.	.	PUNCT
easat-3738	39	1	the	the	DET
easat-3738	39	2	effects	effect	NOUN
easat-3738	39	3	of	of	ADP
easat-3738	39	4	inflammation	inflammation	NOUN
easat-3738	39	5	are	be	AUX
easat-3738	39	6	a	a	DET
easat-3738	39	7	key	key	ADJ
easat-3738	39	8	factor	factor	NOUN
easat-3738	39	9	in	in	ADP
easat-3738	39	10	the	the	DET
easat-3738	39	11	recruitment	recruitment	NOUN
easat-3738	39	12	of	of	ADP
easat-3738	39	13	the	the	DET
easat-3738	39	14	mesenchymal	mesenchymal	ADJ
easat-3738	39	15	stem	stem	NOUN
easat-3738	39	16	cells	cell	NOUN
easat-3738	39	17	.	.	PUNCT
easat-3738	40	1	hence	hence	ADV
easat-3738	40	2	,	,	PUNCT
easat-3738	40	3	cellular	cellular	ADJ
easat-3738	40	4	immunity	immunity	NOUN
easat-3738	40	5	is	be	AUX
easat-3738	40	6	integral	integral	ADJ
easat-3738	40	7	to	to	ADP
easat-3738	40	8	the	the	DET
easat-3738	40	9	healing	healing	NOUN
easat-3738	40	10	of	of	ADP
easat-3738	40	11	the	the	DET
easat-3738	40	12	fractured	fractured	ADJ
easat-3738	40	13	bone	bone	NOUN
easat-3738	40	14	.	.	PUNCT
easat-3738	41	1	the	the	DET
easat-3738	41	2	healing	healing	NOUN
easat-3738	41	3	process	process	NOUN
easat-3738	41	4	can	can	AUX
easat-3738	41	5	be	be	AUX
easat-3738	41	6	classified	classify	VERB
easat-3738	41	7	into	into	ADP
easat-3738	41	8	primary	primary	ADJ
easat-3738	41	9	and	and	CCONJ
easat-3738	41	10	secondary	secondary	ADJ
easat-3738	41	11	healing	healing	NOUN
easat-3738	41	12	,	,	PUNCT
easat-3738	41	13	each	each	PRON
easat-3738	41	14	has	have	VERB
easat-3738	41	15	its	its	PRON
easat-3738	41	16	own	own	ADJ
easat-3738	41	17	distinct	distinct	ADJ
easat-3738	41	18	mechanisms	mechanism	NOUN
easat-3738	41	19	and	and	CCONJ
easat-3738	41	20	requirements	requirement	NOUN
easat-3738	41	21	for	for	ADP
easat-3738	41	22	healing	healing	NOUN
easat-3738	41	23	.	.	PUNCT
easat-3738	42	1	1.1	1.1	NUM
easat-3738	42	2	.	.	PUNCT
easat-3738	42	3	primary	primary	ADJ
easat-3738	42	4	bone	bone	NOUN
easat-3738	42	5	healing	healing	NOUN
easat-3738	42	6	primary	primary	ADJ
easat-3738	42	7	healing	healing	NOUN
easat-3738	42	8	is	be	AUX
easat-3738	42	9	known	know	VERB
easat-3738	42	10	as	as	ADP
easat-3738	42	11	direct	direct	ADJ
easat-3738	42	12	bone	bone	NOUN
easat-3738	42	13	healing	healing	NOUN
easat-3738	42	14	,	,	PUNCT
easat-3738	42	15	it	it	PRON
easat-3738	42	16	occurs	occur	VERB
easat-3738	42	17	when	when	SCONJ
easat-3738	42	18	the	the	DET
easat-3738	42	19	fractured	fractured	ADJ
easat-3738	42	20	bone	bone	NOUN
easat-3738	42	21	fragments	fragment	NOUN
easat-3738	42	22	are	be	AUX
easat-3738	42	23	precisely	precisely	ADV
easat-3738	42	24	reduced	reduce	VERB
easat-3738	42	25	,	,	PUNCT
easat-3738	42	26	aligned	align	VERB
easat-3738	42	27	,	,	PUNCT
easat-3738	42	28	and	and	CCONJ
easat-3738	42	29	fixed	fix	VERB
easat-3738	42	30	under	under	ADP
easat-3738	42	31	compression	compression	NOUN
easat-3738	42	32	,	,	PUNCT
easat-3738	42	33	ensuring	ensure	VERB
easat-3738	42	34	no	no	DET
easat-3738	42	35	movement	movement	NOUN
easat-3738	42	36	at	at	ADP
easat-3738	42	37	the	the	DET
easat-3738	42	38	fracture	fracture	PROPN
easat-3738	42	39	site	site	NOUN
easat-3738	42	40	.	.	PUNCT
easat-3738	43	1	under	under	ADP
easat-3738	43	2	these	these	DET
easat-3738	43	3	conditions	condition	NOUN
easat-3738	43	4	,	,	PUNCT
easat-3738	43	5	the	the	DET
easat-3738	43	6	bone	bone	NOUN
easat-3738	43	7	heals	heal	VERB
easat-3738	43	8	through	through	ADP
easat-3738	43	9	direct	direct	ADJ
easat-3738	43	10	remodeling	remodeling	NOUN
easat-3738	43	11	of	of	ADP
easat-3738	43	12	lamellar	lamellar	ADJ
easat-3738	43	13	bone	bone	NOUN
easat-3738	43	14	and	and	CCONJ
easat-3738	43	15	haversian	haversian	ADJ
easat-3738	43	16	canals	canal	NOUN
easat-3738	43	17	.	.	PUNCT
easat-3738	44	1	,	,	PUNCT
easat-3738	44	2	the	the	DET
easat-3738	44	3	bone	bone	NOUN
easat-3738	44	4	can	can	AUX
easat-3738	44	5	heal	heal	VERB
easat-3738	44	6	through	through	ADP
easat-3738	44	7	direct	direct	ADJ
easat-3738	44	8	remodeling	remodeling	NOUN
easat-3738	44	9	of	of	ADP
easat-3738	44	10	lamellar	lamellar	ADJ
easat-3738	44	11	bone	bone	NOUN
easat-3738	44	12	and	and	CCONJ
easat-3738	44	13	haversian	haversian	ADJ
easat-3738	44	14	canals	canal	NOUN
easat-3738	44	15	[	[	X
easat-3738	44	16	3	3	NUM
easat-3738	44	17	,	,	PUNCT
easat-3738	44	18	10	10	NUM
easat-3738	44	19	]	]	PUNCT
easat-3738	44	20	.	.	PUNCT
easat-3738	45	1	bone	bone	NOUN
easat-3738	45	2	on	on	ADP
easat-3738	45	3	one	one	NUM
easat-3738	45	4	side	side	NOUN
easat-3738	45	5	of	of	ADP
easat-3738	45	6	the	the	DET
easat-3738	45	7	cortex	cortex	NOUN
easat-3738	45	8	must	must	AUX
easat-3738	45	9	connect	connect	VERB
easat-3738	45	10	physically	physically	ADV
easat-3738	45	11	with	with	ADP
easat-3738	45	12	bone	bone	NOUN
easat-3738	45	13	on	on	ADP
easat-3738	45	14	the	the	DET
easat-3738	45	15	other	other	ADJ
easat-3738	45	16	side	side	NOUN
easat-3738	45	17	to	to	PART
easat-3738	45	18	re	re	VERB
easat-3738	45	19	-	-	VERB
easat-3738	45	20	establish	establish	VERB
easat-3738	45	21	the	the	DET
easat-3738	45	22	mechanical	mechanical	ADJ
easat-3738	45	23	and	and	CCONJ
easat-3738	45	24	physical	physical	ADJ
easat-3738	45	25	continuity	continuity	NOUN
easat-3738	45	26	.	.	PUNCT
easat-3738	46	1	cutting	cut	VERB
easat-3738	46	2	cones	cone	NOUN
easat-3738	46	3	are	be	AUX
easat-3738	46	4	formed	form	VERB
easat-3738	46	5	at	at	ADP
easat-3738	46	6	the	the	DET
easat-3738	46	7	ends	end	NOUN
easat-3738	46	8	of	of	ADP
easat-3738	46	9	the	the	DET
easat-3738	46	10	osteons	osteon	NOUN
easat-3738	46	11	nearest	near	ADJ
easat-3738	46	12	to	to	ADP
easat-3738	46	13	the	the	DET
easat-3738	46	14	fracture	fracture	NOUN
easat-3738	46	15	site	site	NOUN
easat-3738	46	16	[	[	X
easat-3738	46	17	10	10	NUM
easat-3738	46	18	]	]	PUNCT
easat-3738	46	19	.	.	PUNCT
easat-3738	47	1	these	these	DET
easat-3738	47	2	cones	cone	NOUN
easat-3738	47	3	cross	cross	VERB
easat-3738	47	4	the	the	DET
easat-3738	47	5	fracture	fracture	PROPN
easat-3738	47	6	line	line	NOUN
easat-3738	47	7	,	,	PUNCT
easat-3738	47	8	forming	form	VERB
easat-3738	47	9	longitudinal	longitudinal	ADJ
easat-3738	47	10	cavities	cavity	NOUN
easat-3738	47	11	via	via	ADP
easat-3738	47	12	the	the	DET
easat-3738	47	13	activity	activity	NOUN
easat-3738	47	14	of	of	ADP
easat-3738	47	15	osteoclasts	osteoclast	NOUN
easat-3738	47	16	,	,	PUNCT
easat-3738	47	17	then	then	ADV
easat-3738	47	18	these	these	DET
easat-3738	47	19	cavities	cavity	NOUN
easat-3738	47	20	are	be	AUX
easat-3738	47	21	filled	fill	VERB
easat-3738	47	22	with	with	ADP
easat-3738	47	23	bone	bone	NOUN
easat-3738	47	24	matrix	matrix	NOUN
easat-3738	47	25	,	,	PUNCT
easat-3738	47	26	leading	lead	VERB
easat-3738	47	27	to	to	ADP
easat-3738	47	28	formation	formation	NOUN
easat-3738	47	29	of	of	ADP
easat-3738	47	30	bony	bony	NOUN
easat-3738	47	31	union	union	NOUN
easat-3738	47	32	and	and	CCONJ
easat-3738	47	33	restoration	restoration	NOUN
easat-3738	47	34	of	of	ADP
easat-3738	47	35	haversian	haversian	ADJ
easat-3738	47	36	systems	system	NOUN
easat-3738	47	37	and	and	CCONJ
easat-3738	47	38	re	re	VERB
easat-3738	47	39	-	-	VERB
easat-3738	47	40	establishing	establish	VERB
easat-3738	47	41	blood	blood	NOUN
easat-3738	47	42	supply	supply	NOUN
easat-3738	48	1	[	[	X
easat-3738	48	2	11	11	NUM
easat-3738	48	3	]	]	PUNCT
easat-3738	48	4	.	.	PUNCT
easat-3738	49	1	eventually	eventually	ADV
easat-3738	49	2	,	,	PUNCT
easat-3738	49	3	the	the	DET
easat-3738	49	4	osteons	osteon	NOUN
easat-3738	49	5	mature	mature	VERB
easat-3738	49	6	and	and	CCONJ
easat-3738	49	7	remodel	remodel	VERB
easat-3738	49	8	into	into	ADP
easat-3738	49	9	lamellar	lamellar	ADJ
easat-3738	49	10	bone	bone	NOUN
easat-3738	49	11	,	,	PUNCT
easat-3738	49	12	healing	heal	VERB
easat-3738	49	13	the	the	DET
easat-3738	49	14	fracture	fracture	NOUN
easat-3738	49	15	site	site	NOUN
easat-3738	49	16	without	without	ADP
easat-3738	49	17	the	the	DET
easat-3738	49	18	formation	formation	NOUN
easat-3738	49	19	of	of	ADP
easat-3738	49	20	callus	callus	ADJ
easat-3738	49	21	or	or	CCONJ
easat-3738	49	22	inflammation	inflammation	NOUN
easat-3738	49	23	[	[	X
easat-3738	49	24	12	12	NUM
easat-3738	49	25	]	]	PUNCT
easat-3738	49	26	.	.	PUNCT
easat-3738	50	1	1.2	1.2	NUM
easat-3738	50	2	.	.	PUNCT
easat-3738	50	3	secondary	secondary	ADJ
easat-3738	50	4	bone	bone	NOUN
easat-3738	50	5	healing	heal	VERB
easat-3738	50	6	the	the	DET
easat-3738	50	7	secondary	secondary	ADJ
easat-3738	50	8	bone	bone	NOUN
easat-3738	50	9	healing	healing	NOUN
easat-3738	50	10	is	be	AUX
easat-3738	50	11	called	call	VERB
easat-3738	50	12	indirect	indirect	ADJ
easat-3738	50	13	bone	bone	NOUN
easat-3738	50	14	healing	healing	NOUN
easat-3738	50	15	,	,	PUNCT
easat-3738	50	16	it	it	PRON
easat-3738	50	17	is	be	AUX
easat-3738	50	18	the	the	DET
easat-3738	50	19	most	most	ADV
easat-3738	50	20	common	common	ADJ
easat-3738	50	21	method	method	NOUN
easat-3738	50	22	of	of	ADP
easat-3738	50	23	bone	bone	NOUN
easat-3738	50	24	healing	healing	NOUN
easat-3738	50	25	to	to	PART
easat-3738	50	26	exist	exist	VERB
easat-3738	50	27	,	,	PUNCT
easat-3738	50	28	including	include	VERB
easat-3738	50	29	both	both	CCONJ
easat-3738	50	30	endochondral	endochondral	ADJ
easat-3738	50	31	and	and	CCONJ
easat-3738	50	32	intramembranous	intramembranous	ADJ
easat-3738	50	33	processes	process	NOUN
easat-3738	50	34	[	[	X
easat-3738	50	35	13	13	NUM
easat-3738	50	36	]	]	PUNCT
easat-3738	50	37	.	.	PUNCT
easat-3738	51	1	anatomical	anatomical	ADJ
easat-3738	51	2	reduction	reduction	NOUN
easat-3738	51	3	or	or	CCONJ
easat-3738	51	4	rigid	rigid	ADJ
easat-3738	51	5	stability	stability	NOUN
easat-3738	51	6	are	be	AUX
easat-3738	51	7	not	not	PART
easat-3738	51	8	required	require	VERB
easat-3738	51	9	in	in	ADP
easat-3738	51	10	such	such	ADJ
easat-3738	51	11	types	type	NOUN
easat-3738	51	12	of	of	ADP
easat-3738	51	13	healing	healing	NOUN
easat-3738	51	14	but	but	CCONJ
easat-3738	51	15	enhanced	enhance	VERB
easat-3738	51	16	by	by	ADP
easat-3738	51	17	micro	micro	NOUN
easat-3738	51	18	-	-	NOUN
easat-3738	51	19	motion	motion	NOUN
easat-3738	51	20	and	and	CCONJ
easat-3738	51	21	weight	weight	NOUN
easat-3738	51	22	-	-	PUNCT
easat-3738	51	23	bearing	bear	VERB
easat-3738	51	24	activities	activity	NOUN
easat-3738	51	25	.	.	PUNCT
easat-3738	52	1	however	however	ADV
easat-3738	52	2	,	,	PUNCT
easat-3738	52	3	excessive	excessive	ADJ
easat-3738	52	4	movement	movement	NOUN
easat-3738	52	5	or	or	CCONJ
easat-3738	52	6	load	load	NOUN
easat-3738	52	7	can	can	AUX
easat-3738	52	8	result	result	VERB
easat-3738	52	9	in	in	ADP
easat-3738	52	10	delayed	delay	VERB
easat-3738	52	11	healing	healing	NOUN
easat-3738	52	12	or	or	CCONJ
easat-3738	52	13	nonunion	nonunion	NOUN
easat-3738	52	14	[	[	X
easat-3738	52	15	14	14	NUM
easat-3738	52	16	]	]	PUNCT
easat-3738	52	17	.	.	PUNCT
easat-3738	53	1	secondary	secondary	ADJ
easat-3738	53	2	bone	bone	NOUN
easat-3738	53	3	healing	healing	NOUN
easat-3738	53	4	typically	typically	ADV
easat-3738	53	5	occurs	occur	VERB
easat-3738	53	6	in	in	ADP
easat-3738	53	7	non	non	ADJ
easat-3738	53	8	-	-	ADJ
easat-3738	53	9	operative	operative	ADJ
easat-3738	53	10	treatments	treatment	NOUN
easat-3738	53	11	and	and	CCONJ
easat-3738	53	12	certain	certain	ADJ
easat-3738	53	13	surgical	surgical	ADJ
easat-3738	53	14	procedures	procedure	NOUN
easat-3738	53	15	that	that	PRON
easat-3738	53	16	allow	allow	VERB
easat-3738	53	17	some	some	DET
easat-3738	53	18	movement	movement	NOUN
easat-3738	53	19	at	at	ADP
easat-3738	53	20	the	the	DET
easat-3738	53	21	fracture	fracture	PROPN
easat-3738	53	22	site	site	NOUN
easat-3738	53	23	,	,	PUNCT
easat-3738	53	24	such	such	ADJ
easat-3738	53	25	as	as	ADP
easat-3738	53	26	intramedullary	intramedullary	ADJ
easat-3738	53	27	nailing	nailing	NOUN
easat-3738	53	28	,	,	PUNCT
easat-3738	53	29	external	external	ADJ
easat-3738	53	30	fixation	fixation	NOUN
easat-3738	53	31	,	,	PUNCT
easat-3738	53	32	or	or	CCONJ
easat-3738	53	33	internal	internal	ADJ
easat-3738	53	34	fixation	fixation	NOUN
easat-3738	53	35	of	of	ADP
easat-3738	53	36	complex	complex	ADJ
easat-3738	53	37	comminuted	comminuted	ADJ
easat-3738	53	38	fractures	fracture	NOUN
easat-3738	53	39	[	[	X
easat-3738	53	40	15	15	NUM
easat-3738	53	41	-	-	SYM
easat-3738	53	42	17	17	NUM
easat-3738	53	43	]	]	PUNCT
easat-3738	53	44	.	.	PUNCT
easat-3738	54	1	1.3	1.3	NUM
easat-3738	54	2	.	.	PUNCT
easat-3738	54	3	stages	stage	NOUN
easat-3738	54	4	of	of	ADP
easat-3738	54	5	bone	bone	NOUN
easat-3738	54	6	healing	heal	VERB
easat-3738	54	7	the	the	DET
easat-3738	54	8	bone	bone	NOUN
easat-3738	54	9	fracture	fracture	NOUN
easat-3738	54	10	healing	healing	NOUN
easat-3738	54	11	can	can	AUX
easat-3738	54	12	be	be	AUX
easat-3738	54	13	classified	classify	VERB
easat-3738	54	14	into	into	ADP
easat-3738	54	15	3	3	NUM
easat-3738	54	16	or	or	CCONJ
easat-3738	54	17	4	4	NUM
easat-3738	54	18	phases	phase	NOUN
easat-3738	54	19	as	as	SCONJ
easat-3738	54	20	seen	see	VERB
easat-3738	54	21	in	in	ADP
easat-3738	54	22	figure	figure	NOUN
easat-3738	54	23	1	1	NUM
easat-3738	54	24	,	,	PUNCT
easat-3738	54	25	those	those	DET
easat-3738	54	26	phases	phase	NOUN
easat-3738	54	27	are	be	AUX
easat-3738	54	28	:	:	PUNCT
easat-3738	54	29	1.3.1	1.3.1	X
easat-3738	54	30	.	.	PUNCT
easat-3738	54	31	inflammatory	inflammatory	ADJ
easat-3738	54	32	phase	phase	NOUN
easat-3738	54	33	(	(	PUNCT
easat-3738	54	34	hematoma	hematoma	NOUN
easat-3738	54	35	formation	formation	NOUN
easat-3738	54	36	)	)	PUNCT
easat-3738	54	37	immediately	immediately	ADV
easat-3738	54	38	after	after	ADP
easat-3738	54	39	a	a	DET
easat-3738	54	40	fracture	fracture	NOUN
easat-3738	54	41	,	,	PUNCT
easat-3738	54	42	blood	blood	NOUN
easat-3738	54	43	vessels	vessel	NOUN
easat-3738	54	44	at	at	ADP
easat-3738	54	45	the	the	DET
easat-3738	54	46	injury	injury	NOUN
easat-3738	54	47	site	site	NOUN
easat-3738	54	48	are	be	AUX
easat-3738	54	49	damaged	damage	VERB
easat-3738	54	50	,	,	PUNCT
easat-3738	54	51	leading	lead	VERB
easat-3738	54	52	to	to	ADP
easat-3738	54	53	the	the	DET
easat-3738	54	54	formation	formation	NOUN
easat-3738	54	55	of	of	ADP
easat-3738	54	56	hematoma	hematoma	NOUN
easat-3738	54	57	(	(	PUNCT
easat-3738	54	58	blood	blood	NOUN
easat-3738	54	59	clot	clot	NOUN
easat-3738	54	60	)	)	PUNCT
easat-3738	54	61	.	.	PUNCT
easat-3738	55	1	this	this	DET
easat-3738	55	2	hematoma	hematoma	NOUN
easat-3738	55	3	acts	act	VERB
easat-3738	55	4	as	as	ADP
easat-3738	55	5	a	a	DET
easat-3738	55	6	scaffold	scaffold	NOUN
easat-3738	55	7	for	for	ADP
easat-3738	55	8	the	the	DET
easat-3738	55	9	healing	healing	NOUN
easat-3738	55	10	process	process	NOUN
easat-3738	55	11	.	.	PUNCT
easat-3738	56	1	the	the	DET
easat-3738	56	2	immune	immune	ADJ
easat-3738	56	3	system	system	NOUN
easat-3738	56	4	responds	respond	VERB
easat-3738	56	5	by	by	ADP
easat-3738	56	6	sending	send	VERB
easat-3738	56	7	immune	immune	ADJ
easat-3738	56	8	cells	cell	NOUN
easat-3738	56	9	,	,	PUNCT
easat-3738	56	10	such	such	ADJ
easat-3738	56	11	as	as	ADP
easat-3738	56	12	macrophages	macrophage	NOUN
easat-3738	56	13	and	and	CCONJ
easat-3738	56	14	neutrophils	neutrophil	NOUN
easat-3738	56	15	as	as	ADV
easat-3738	56	16	well	well	ADV
easat-3738	56	17	as	as	ADP
easat-3738	56	18	blood	blood	NOUN
easat-3738	56	19	platelets	platelet	NOUN
easat-3738	56	20	,	,	PUNCT
easat-3738	56	21	to	to	ADP
easat-3738	56	22	the	the	DET
easat-3738	56	23	fracture	fracture	PROPN
easat-3738	56	24	site	site	NOUN
easat-3738	56	25	.	.	PUNCT
easat-3738	57	1	these	these	DET
easat-3738	57	2	cells	cell	NOUN
easat-3738	57	3	help	help	VERB
easat-3738	57	4	to	to	PART
easat-3738	57	5	clear	clear	VERB
easat-3738	57	6	debris	debris	NOUN
easat-3738	57	7	and	and	CCONJ
easat-3738	57	8	release	release	NOUN
easat-3738	57	9	interleukins	interleukin	VERB
easat-3738	57	10	cytokines	cytokine	NOUN
easat-3738	57	11	such	such	ADJ
easat-3738	57	12	as	as	ADP
easat-3738	57	13	(	(	PUNCT
easat-3738	57	14	il-1	il-1	NUM
easat-3738	57	15	,	,	PUNCT
easat-3738	57	16	il-6	il-6	NUM
easat-3738	57	17	,	,	PUNCT
easat-3738	57	18	il-10	il-10	PRON
easat-3738	57	19	,	,	PUNCT
easat-3738	57	20	il-11	il-11	PRON
easat-3738	57	21	,	,	PUNCT
easat-3738	57	22	il	il	PROPN
easat-3738	57	23	12	12	NUM
easat-3738	57	24	,	,	PUNCT
easat-3738	57	25	il-23	il-23	NOUN
easat-3738	57	26	)	)	PUNCT
easat-3738	57	27	,	,	PUNCT
easat-3738	57	28	transforming	transform	VERB
easat-3738	57	29	growth	growth	NOUN
easat-3738	57	30	factor	factor	NOUN
easat-3738	57	31	beta	beta	NOUN
easat-3738	57	32	(	(	PUNCT
easat-3738	57	33	tgf	tgf	NOUN
easat-3738	57	34	-	-	PUNCT
easat-3738	57	35	beta	beta	NOUN
easat-3738	57	36	)	)	PUNCT
easat-3738	57	37	,	,	PUNCT
easat-3738	57	38	tumor	tumor	NOUN
easat-3738	57	39	necrosis	necrosis	NOUN
easat-3738	57	40	factor	factor	NOUN
easat-3738	57	41	-	-	PUNCT
easat-3738	57	42	alpha	alpha	NOUN
easat-3738	57	43	(	(	PUNCT
easat-3738	57	44	tnf	tnf	PROPN
easat-3738	57	45	-	-	PUNCT
easat-3738	57	46	α	α	NOUN
easat-3738	57	47	)	)	PUNCT
easat-3738	57	48	,	,	PUNCT
easat-3738	57	49	vascular	vascular	ADJ
easat-3738	57	50	endothelial	endothelial	ADJ
easat-3738	57	51	growth	growth	NOUN
easat-3738	57	52	factor	factor	NOUN
easat-3738	57	53	(	(	PUNCT
easat-3738	57	54	vegf	vegf	PROPN
easat-3738	57	55	)	)	PUNCT
easat-3738	57	56	,	,	PUNCT
easat-3738	57	57	bone	bone	NOUN
easat-3738	57	58	morphogenetic	morphogenetic	ADJ
easat-3738	57	59	proteins	protein	NOUN
easat-3738	57	60	(	(	PUNCT
easat-3738	57	61	bmps	bmp	NOUN
easat-3738	57	62	)	)	PUNCT
easat-3738	57	63	and	and	CCONJ
easat-3738	57	64	platelet	platelet	ADJ
easat-3738	57	65	-	-	PUNCT
easat-3738	57	66	derived	derive	VERB
easat-3738	57	67	growth	growth	NOUN
easat-3738	57	68	factors	factor	NOUN
easat-3738	57	69	(	(	PUNCT
easat-3738	57	70	pdgf	pdgf	NOUN
easat-3738	57	71	)	)	PUNCT
easat-3738	58	1	[	[	X
easat-3738	58	2	18	18	NUM
easat-3738	58	3	]	]	PUNCT
easat-3738	58	4	.	.	PUNCT
easat-3738	59	1	furthermore	furthermore	ADV
easat-3738	59	2	,	,	PUNCT
easat-3738	59	3	these	these	DET
easat-3738	59	4	cytokines	cytokine	NOUN
easat-3738	59	5	stimulate	stimulate	VERB
easat-3738	59	6	the	the	DET
easat-3738	59	7	essential	essential	ADJ
easat-3738	59	8	2538	2538	NUM
easat-3738	59	9	edelweiss	edelweiss	PROPN
easat-3738	59	10	applied	apply	VERB
easat-3738	59	11	science	science	NOUN
easat-3738	59	12	and	and	CCONJ
easat-3738	59	13	technology	technology	NOUN
easat-3738	59	14	issn	issn	PROPN
easat-3738	59	15	:	:	PUNCT
easat-3738	59	16	2576	2576	NUM
easat-3738	59	17	-	-	SYM
easat-3738	59	18	8484	8484	NUM
easat-3738	59	19	vol	vol	NOUN
easat-3738	59	20	.	.	PROPN
easat-3738	60	1	8	8	NUM
easat-3738	60	2	,	,	PUNCT
easat-3738	60	3	no	no	INTJ
easat-3738	60	4	.	.	NOUN
easat-3738	60	5	5	5	NUM
easat-3738	60	6	:	:	SYM
easat-3738	60	7	2536	2536	NUM
easat-3738	60	8	-	-	SYM
easat-3738	60	9	2541	2541	NUM
easat-3738	60	10	,	,	PUNCT
easat-3738	60	11	2024	2024	NUM
easat-3738	60	12	doi	doi	NOUN
easat-3738	60	13	:	:	PUNCT
easat-3738	60	14	10.55214/25768484.v8i6.3738	10.55214/25768484.v8i6.3738	NUM
easat-3738	60	15	©	©	NOUN
easat-3738	60	16	2024	2024	NUM
easat-3738	60	17	by	by	ADP
easat-3738	60	18	the	the	DET
easat-3738	60	19	authors	author	NOUN
easat-3738	60	20	;	;	PUNCT
easat-3738	61	1	licensee	licensee	PROPN
easat-3738	61	2	learning	learn	VERB
easat-3738	61	3	gate	gate	VERB
easat-3738	61	4	cellular	cellular	ADJ
easat-3738	61	5	biological	biological	ADJ
easat-3738	61	6	sense	sense	NOUN
easat-3738	61	7	at	at	ADP
easat-3738	61	8	the	the	DET
easat-3738	61	9	fracture	fracture	NOUN
easat-3738	61	10	site	site	NOUN
easat-3738	61	11	to	to	PART
easat-3738	61	12	promote	promote	VERB
easat-3738	61	13	inflammation	inflammation	NOUN
easat-3738	61	14	and	and	CCONJ
easat-3738	61	15	attract	attract	VERB
easat-3738	61	16	other	other	ADJ
easat-3738	61	17	cells	cell	NOUN
easat-3738	61	18	necessary	necessary	ADJ
easat-3738	61	19	for	for	ADP
easat-3738	61	20	healing	heal	VERB
easat-3738	61	21	[	[	X
easat-3738	61	22	19	19	NUM
easat-3738	61	23	]	]	PUNCT
easat-3738	61	24	.	.	PUNCT
easat-3738	62	1	1.3.2	1.3.2	X
easat-3738	62	2	.	.	PUNCT
easat-3738	62	3	repair	repair	NOUN
easat-3738	62	4	phase	phase	NOUN
easat-3738	62	5	(	(	PUNCT
easat-3738	62	6	formation	formation	NOUN
easat-3738	62	7	of	of	ADP
easat-3738	62	8	cartilaginous	cartilaginous	ADJ
easat-3738	62	9	and	and	CCONJ
easat-3738	62	10	bony	bony	NOUN
easat-3738	62	11	callus	callus	NOUN
easat-3738	62	12	)	)	PUNCT
easat-3738	62	13	during	during	ADP
easat-3738	62	14	this	this	DET
easat-3738	62	15	phase	phase	NOUN
easat-3738	62	16	,	,	PUNCT
easat-3738	62	17	the	the	DET
easat-3738	62	18	immune	immune	ADJ
easat-3738	62	19	cells	cell	NOUN
easat-3738	62	20	continue	continue	VERB
easat-3738	62	21	to	to	PART
easat-3738	62	22	play	play	VERB
easat-3738	62	23	a	a	DET
easat-3738	62	24	role	role	NOUN
easat-3738	62	25	by	by	ADP
easat-3738	62	26	secreting	secrete	VERB
easat-3738	62	27	factors	factor	NOUN
easat-3738	62	28	that	that	PRON
easat-3738	62	29	promote	promote	VERB
easat-3738	62	30	the	the	DET
easat-3738	62	31	formation	formation	NOUN
easat-3738	62	32	of	of	ADP
easat-3738	62	33	a	a	DET
easat-3738	62	34	soft	soft	ADJ
easat-3738	62	35	callus	callus	NOUN
easat-3738	62	36	made	make	VERB
easat-3738	62	37	of	of	ADP
easat-3738	62	38	fibrocartilage	fibrocartilage	NOUN
easat-3738	62	39	anastomosis	anastomosis	NOUN
easat-3738	62	40	.	.	PUNCT
easat-3738	63	1	this	this	DET
easat-3738	63	2	callus	callus	NOUN
easat-3738	63	3	gradually	gradually	ADV
easat-3738	63	4	transforms	transform	VERB
easat-3738	63	5	into	into	ADP
easat-3738	63	6	a	a	DET
easat-3738	63	7	hard	hard	ADJ
easat-3738	63	8	bony	bony	NOUN
easat-3738	63	9	callus	callus	NOUN
easat-3738	63	10	through	through	ADP
easat-3738	63	11	endochondral	endochondral	ADJ
easat-3738	63	12	ossification	ossification	NOUN
easat-3738	63	13	[	[	X
easat-3738	63	14	20	20	NUM
easat-3738	63	15	]	]	PUNCT
easat-3738	63	16	as	as	SCONJ
easat-3738	63	17	new	new	ADJ
easat-3738	63	18	bone	bone	NOUN
easat-3738	63	19	tissue	tissue	NOUN
easat-3738	63	20	begins	begin	VERB
easat-3738	63	21	to	to	PART
easat-3738	63	22	form	form	VERB
easat-3738	63	23	.	.	PUNCT
easat-3738	64	1	immune	immune	ADJ
easat-3738	64	2	cells	cell	NOUN
easat-3738	64	3	like	like	ADP
easat-3738	64	4	macrophages	macrophage	NOUN
easat-3738	64	5	help	help	NOUN
easat-3738	64	6	in	in	ADP
easat-3738	64	7	the	the	DET
easat-3738	64	8	transformation	transformation	NOUN
easat-3738	64	9	of	of	ADP
easat-3738	64	10	progenitor	progenitor	NOUN
easat-3738	64	11	cells	cell	NOUN
easat-3738	64	12	(	(	PUNCT
easat-3738	64	13	mesenchymal	mesenchymal	ADJ
easat-3738	64	14	stem	stem	NOUN
easat-3738	64	15	cells	cell	NOUN
easat-3738	64	16	)	)	PUNCT
easat-3738	64	17	into	into	ADP
easat-3738	64	18	chondroblasts	chondroblast	NOUN
easat-3738	64	19	,	,	PUNCT
easat-3738	64	20	fibroblasts	fibroblast	NOUN
easat-3738	64	21	and	and	CCONJ
easat-3738	64	22	osteoblasts	osteoblast	NOUN
easat-3738	64	23	,	,	PUNCT
easat-3738	64	24	which	which	PRON
easat-3738	64	25	are	be	AUX
easat-3738	64	26	cells	cell	NOUN
easat-3738	64	27	responsible	responsible	ADJ
easat-3738	64	28	for	for	ADP
easat-3738	64	29	bone	bone	NOUN
easat-3738	64	30	formation	formation	NOUN
easat-3738	64	31	[	[	X
easat-3738	64	32	21	21	NUM
easat-3738	64	33	,	,	PUNCT
easat-3738	64	34	22	22	NUM
easat-3738	64	35	]	]	PUNCT
easat-3738	64	36	.	.	PUNCT
easat-3738	65	1	1.3.3	1.3.3	X
easat-3738	65	2	.	.	PUNCT
easat-3738	65	3	remodeling	remodeling	NOUN
easat-3738	65	4	phase	phase	NOUN
easat-3738	65	5	in	in	ADP
easat-3738	65	6	the	the	DET
easat-3738	65	7	final	final	ADJ
easat-3738	65	8	phase	phase	NOUN
easat-3738	65	9	,	,	PUNCT
easat-3738	65	10	the	the	DET
easat-3738	65	11	newly	newly	ADV
easat-3738	65	12	formed	form	VERB
easat-3738	65	13	bone	bone	NOUN
easat-3738	65	14	is	be	AUX
easat-3738	65	15	remodeled	remodel	VERB
easat-3738	65	16	to	to	PART
easat-3738	65	17	restore	restore	VERB
easat-3738	65	18	its	its	PRON
easat-3738	65	19	original	original	ADJ
easat-3738	65	20	shape	shape	NOUN
easat-3738	65	21	and	and	CCONJ
easat-3738	65	22	strength	strength	NOUN
easat-3738	65	23	through	through	ADP
easat-3738	65	24	transformation	transformation	NOUN
easat-3738	65	25	of	of	ADP
easat-3738	65	26	the	the	DET
easat-3738	65	27	bony	bony	NOUN
easat-3738	65	28	callus	callus	NOUN
easat-3738	65	29	by	by	ADP
easat-3738	65	30	osteoclasts	osteoclast	NOUN
easat-3738	65	31	and	and	CCONJ
easat-3738	65	32	osteoblasts	osteoblast	NOUN
easat-3738	65	33	into	into	ADP
easat-3738	65	34	compact	compact	ADJ
easat-3738	65	35	bone	bone	NOUN
easat-3738	65	36	in	in	ADP
easat-3738	65	37	the	the	DET
easat-3738	65	38	center	center	NOUN
easat-3738	65	39	,	,	PUNCT
easat-3738	65	40	and	and	CCONJ
easat-3738	65	41	lamellar	lamellar	ADJ
easat-3738	65	42	bone	bone	NOUN
easat-3738	65	43	at	at	ADP
easat-3738	65	44	the	the	DET
easat-3738	65	45	peripheral	peripheral	ADJ
easat-3738	65	46	side	side	NOUN
easat-3738	65	47	of	of	ADP
easat-3738	65	48	the	the	DET
easat-3738	65	49	callus	callus	NOUN
easat-3738	65	50	[	[	X
easat-3738	65	51	23	23	NUM
easat-3738	65	52	]	]	SYM
easat-3738	65	53	.	.	PUNCT
easat-3738	66	1	immune	immune	ADJ
easat-3738	66	2	cells	cell	NOUN
easat-3738	66	3	continue	continue	VERB
easat-3738	66	4	to	to	PART
easat-3738	66	5	regulate	regulate	VERB
easat-3738	66	6	this	this	DET
easat-3738	66	7	process	process	NOUN
easat-3738	66	8	by	by	ADP
easat-3738	66	9	balancing	balance	VERB
easat-3738	66	10	bone	bone	NOUN
easat-3738	66	11	formation	formation	NOUN
easat-3738	66	12	and	and	CCONJ
easat-3738	66	13	resorption	resorption	NOUN
easat-3738	66	14	.	.	PUNCT
easat-3738	67	1	dysregulation	dysregulation	NOUN
easat-3738	67	2	of	of	ADP
easat-3738	67	3	the	the	DET
easat-3738	67	4	immune	immune	ADJ
easat-3738	67	5	response	response	NOUN
easat-3738	67	6	can	can	AUX
easat-3738	67	7	lead	lead	VERB
easat-3738	67	8	to	to	ADP
easat-3738	67	9	complications	complication	NOUN
easat-3738	67	10	such	such	ADJ
easat-3738	67	11	as	as	ADP
easat-3738	67	12	delay	delay	NOUN
easat-3738	67	13	in	in	ADP
easat-3738	67	14	the	the	DET
easat-3738	67	15	expected	expect	VERB
easat-3738	67	16	healing	healing	NOUN
easat-3738	67	17	time	time	NOUN
easat-3738	67	18	or	or	CCONJ
easat-3738	67	19	non	non	NOUN
easat-3738	67	20	-	-	NOUN
easat-3738	67	21	union	union	NOUN
easat-3738	67	22	of	of	ADP
easat-3738	67	23	the	the	DET
easat-3738	67	24	fracture	fracture	NOUN
easat-3738	67	25	[	[	X
easat-3738	67	26	21	21	NUM
easat-3738	67	27	]	]	PUNCT
easat-3738	67	28	.	.	PUNCT
easat-3738	68	1	1.4	1.4	NUM
easat-3738	68	2	.	.	PUNCT
easat-3738	68	3	factors	factor	NOUN
easat-3738	68	4	influencing	influence	VERB
easat-3738	68	5	healing	heal	VERB
easat-3738	68	6	1.4.1	1.4.1	NUM
easat-3738	68	7	.	.	PUNCT
easat-3738	69	1	the	the	DET
easat-3738	69	2	location	location	NOUN
easat-3738	69	3	of	of	ADP
easat-3738	69	4	the	the	DET
easat-3738	69	5	fracture	fracture	NOUN
easat-3738	69	6	the	the	DET
easat-3738	69	7	location	location	NOUN
easat-3738	69	8	of	of	ADP
easat-3738	69	9	bone	bone	NOUN
easat-3738	69	10	fracture	fracture	NOUN
easat-3738	69	11	is	be	AUX
easat-3738	69	12	a	a	DET
easat-3738	69	13	key	key	ADJ
easat-3738	69	14	factor	factor	NOUN
easat-3738	69	15	in	in	ADP
easat-3738	69	16	predicting	predict	VERB
easat-3738	69	17	healing	healing	NOUN
easat-3738	69	18	time	time	NOUN
easat-3738	69	19	owing	owe	VERB
easat-3738	69	20	to	to	ADP
easat-3738	69	21	varying	vary	VERB
easat-3738	69	22	blood	blood	NOUN
easat-3738	69	23	flow	flow	NOUN
easat-3738	69	24	bone	bone	NOUN
easat-3738	69	25	fractures	fracture	NOUN
easat-3738	69	26	close	close	ADJ
easat-3738	69	27	to	to	ADP
easat-3738	69	28	the	the	DET
easat-3738	69	29	center	center	NOUN
easat-3738	69	30	–	–	PUNCT
easat-3738	69	31	like	like	ADP
easat-3738	69	32	the	the	DET
easat-3738	69	33	shaft	shaft	NOUN
easat-3738	69	34	–	–	PUNCT
easat-3738	69	35	heal	heal	VERB
easat-3738	69	36	quicker	quick	ADV
easat-3738	69	37	than	than	ADP
easat-3738	69	38	those	those	PRON
easat-3738	69	39	at	at	ADP
easat-3738	69	40	the	the	DET
easat-3738	69	41	edges	edge	NOUN
easat-3738	69	42	or	or	CCONJ
easat-3738	69	43	articular	articular	ADJ
easat-3738	69	44	regions	region	NOUN
easat-3738	69	45	.	.	PUNCT
easat-3738	70	1	the	the	DET
easat-3738	70	2	latter	latter	ADJ
easat-3738	70	3	present	present	NOUN
easat-3738	70	4	with	with	ADP
easat-3738	70	5	less	less	ADJ
easat-3738	70	6	blood	blood	NOUN
easat-3738	70	7	supply	supply	NOUN
easat-3738	70	8	causing	cause	VERB
easat-3738	70	9	delayed	delayed	ADJ
easat-3738	70	10	healing	healing	NOUN
easat-3738	70	11	[	[	X
easat-3738	70	12	24	24	NUM
easat-3738	70	13	]	]	PUNCT
easat-3738	70	14	.	.	PUNCT
easat-3738	71	1	figure	figure	NOUN
easat-3738	71	2	1	1	NUM
easat-3738	71	3	.	.	PUNCT
easat-3738	71	4	shows	show	VERB
easat-3738	71	5	the	the	DET
easat-3738	71	6	phases	phase	NOUN
easat-3738	71	7	of	of	ADP
easat-3738	71	8	the	the	DET
easat-3738	71	9	bone	bone	NOUN
easat-3738	71	10	fracture	fracture	NOUN
easat-3738	71	11	healing	healing	NOUN
easat-3738	72	1	[	[	X
easat-3738	72	2	1	1	NUM
easat-3738	72	3	]	]	PUNCT
easat-3738	72	4	.	.	PUNCT
easat-3738	73	1	1.4.2	1.4.2	X
easat-3738	73	2	.	.	PUNCT
easat-3738	74	1	patients	patient	NOUN
easat-3738	74	2	’	'	PUNCT
easat-3738	74	3	age	age	NOUN
easat-3738	74	4	the	the	DET
easat-3738	74	5	process	process	NOUN
easat-3738	74	6	of	of	ADP
easat-3738	74	7	fracture	fracture	NOUN
easat-3738	74	8	healing	healing	NOUN
easat-3738	74	9	is	be	AUX
easat-3738	74	10	influenced	influence	VERB
easat-3738	74	11	by	by	ADP
easat-3738	74	12	aging	age	VERB
easat-3738	74	13	,	,	PUNCT
easat-3738	74	14	which	which	PRON
easat-3738	74	15	alters	alter	VERB
easat-3738	74	16	the	the	DET
easat-3738	74	17	inflammatory	inflammatory	ADJ
easat-3738	74	18	response	response	NOUN
easat-3738	74	19	.	.	PUNCT
easat-3738	75	1	this	this	DET
easat-3738	75	2	alteration	alteration	NOUN
easat-3738	75	3	is	be	AUX
easat-3738	75	4	attributed	attribute	VERB
easat-3738	75	5	to	to	ADP
easat-3738	75	6	the	the	DET
easat-3738	75	7	aging	age	VERB
easat-3738	75	8	immune	immune	ADJ
easat-3738	75	9	system	system	NOUN
easat-3738	75	10	itself	itself	PRON
easat-3738	75	11	and	and	CCONJ
easat-3738	75	12	an	an	DET
easat-3738	75	13	increased	increase	VERB
easat-3738	75	14	systemic	systemic	ADJ
easat-3738	75	15	pro	pro	ADJ
easat-3738	75	16	-	-	ADJ
easat-3738	75	17	inflammatory	inflammatory	ADJ
easat-3738	75	18	state	state	NOUN
easat-3738	75	19	.	.	PUNCT
easat-3738	76	1	immune	immune	ADJ
easat-3738	76	2	key	key	ADJ
easat-3738	76	3	cells	cell	NOUN
easat-3738	76	4	involved	involve	VERB
easat-3738	76	5	in	in	ADP
easat-3738	76	6	inflammatory	inflammatory	ADJ
easat-3738	76	7	response	response	NOUN
easat-3738	76	8	,	,	PUNCT
easat-3738	76	9	including	include	VERB
easat-3738	76	10	macrophages	macrophage	NOUN
easat-3738	76	11	,	,	PUNCT
easat-3738	76	12	t	t	NOUN
easat-3738	76	13	cells	cell	NOUN
easat-3738	76	14	,	,	PUNCT
easat-3738	76	15	and	and	CCONJ
easat-3738	76	16	mesenchymal	mesenchymal	ADJ
easat-3738	76	17	stem	stem	NOUN
easat-3738	76	18	cells	cell	NOUN
easat-3738	76	19	,	,	PUNCT
easat-3738	76	20	undergo	undergo	VERB
easat-3738	76	21	age	age	NOUN
easat-3738	76	22	-	-	PUNCT
easat-3738	76	23	related	relate	VERB
easat-3738	76	24	changes	change	NOUN
easat-3738	76	25	that	that	PRON
easat-3738	76	26	can	can	AUX
easat-3738	76	27	affect	affect	VERB
easat-3738	76	28	healing	heal	VERB
easat-3738	76	29	negatively	negatively	ADV
easat-3738	76	30	.	.	PUNCT
easat-3738	77	1	furthermore	furthermore	ADV
easat-3738	77	2	,	,	PUNCT
easat-3738	77	3	older	old	ADJ
easat-3738	77	4	adult	adult	NOUN
easat-3738	77	5	patients	patient	NOUN
easat-3738	77	6	encounter	encounter	VERB
easat-3738	77	7	difficulties	difficulty	NOUN
easat-3738	77	8	with	with	ADP
easat-3738	77	9	vascularization	vascularization	NOUN
easat-3738	77	10	and	and	CCONJ
easat-3738	77	11	angiogenesis	angiogenesis	NOUN
easat-3738	77	12	during	during	ADP
easat-3738	77	13	fracture	fracture	PROPN
easat-3738	77	14	repair	repair	NOUN
easat-3738	77	15	.	.	PUNCT
easat-3738	78	1	2539	2539	NUM
easat-3738	78	2	edelweiss	edelweiss	PROPN
easat-3738	78	3	applied	apply	VERB
easat-3738	78	4	science	science	NOUN
easat-3738	78	5	and	and	CCONJ
easat-3738	78	6	technology	technology	NOUN
easat-3738	78	7	issn	issn	PROPN
easat-3738	78	8	:	:	PUNCT
easat-3738	78	9	2576	2576	NUM
easat-3738	78	10	-	-	SYM
easat-3738	78	11	8484	8484	NUM
easat-3738	78	12	vol	vol	NOUN
easat-3738	78	13	.	.	PROPN
easat-3738	78	14	8	8	NUM
easat-3738	78	15	,	,	PUNCT
easat-3738	78	16	no	no	INTJ
easat-3738	78	17	.	.	NOUN
easat-3738	78	18	5	5	NUM
easat-3738	78	19	:	:	SYM
easat-3738	78	20	2536	2536	NUM
easat-3738	78	21	-	-	SYM
easat-3738	78	22	2541	2541	NUM
easat-3738	78	23	,	,	PUNCT
easat-3738	78	24	2024	2024	NUM
easat-3738	78	25	doi	doi	NOUN
easat-3738	78	26	:	:	PUNCT
easat-3738	78	27	10.55214/25768484.v8i6.3738	10.55214/25768484.v8i6.3738	NUM
easat-3738	78	28	©	©	NOUN
easat-3738	78	29	2024	2024	NUM
easat-3738	78	30	by	by	ADP
easat-3738	78	31	the	the	DET
easat-3738	78	32	authors	author	NOUN
easat-3738	78	33	;	;	PUNCT
easat-3738	78	34	licensee	licensee	PROPN
easat-3738	78	35	learning	learning	NOUN
easat-3738	78	36	gate	gate	NOUN
easat-3738	78	37	finally	finally	ADV
easat-3738	78	38	,	,	PUNCT
easat-3738	78	39	there	there	PRON
easat-3738	78	40	is	be	VERB
easat-3738	78	41	a	a	DET
easat-3738	78	42	reduction	reduction	NOUN
easat-3738	78	43	in	in	ADP
easat-3738	78	44	the	the	DET
easat-3738	78	45	activity	activity	NOUN
easat-3738	78	46	and	and	CCONJ
easat-3738	78	47	number	number	NOUN
easat-3738	78	48	of	of	ADP
easat-3738	78	49	osteochondral	osteochondral	ADJ
easat-3738	78	50	cells	cell	NOUN
easat-3738	78	51	and	and	CCONJ
easat-3738	78	52	their	their	PRON
easat-3738	78	53	progenitors	progenitor	NOUN
easat-3738	78	54	within	within	ADP
easat-3738	78	55	the	the	DET
easat-3738	78	56	callus	callus	NOUN
easat-3738	78	57	[	[	X
easat-3738	78	58	25	25	NUM
easat-3738	78	59	]	]	PUNCT
easat-3738	78	60	.	.	PUNCT
easat-3738	79	1	1.4.3	1.4.3	NUM
easat-3738	79	2	.	.	PUNCT
easat-3738	79	3	level	level	NOUN
easat-3738	79	4	of	of	ADP
easat-3738	79	5	physical	physical	ADJ
easat-3738	79	6	activity	activity	NOUN
easat-3738	79	7	the	the	DET
easat-3738	79	8	impact	impact	NOUN
easat-3738	79	9	of	of	ADP
easat-3738	79	10	physical	physical	ADJ
easat-3738	79	11	activity	activity	NOUN
easat-3738	79	12	on	on	ADP
easat-3738	79	13	the	the	DET
easat-3738	79	14	healing	healing	NOUN
easat-3738	79	15	process	process	NOUN
easat-3738	79	16	is	be	AUX
easat-3738	79	17	well	well	ADV
easat-3738	79	18	studied	study	VERB
easat-3738	79	19	.	.	PUNCT
easat-3738	80	1	patients	patient	NOUN
easat-3738	80	2	who	who	PRON
easat-3738	80	3	have	have	AUX
easat-3738	80	4	become	become	VERB
easat-3738	80	5	bedridden	bedridden	ADJ
easat-3738	80	6	have	have	VERB
easat-3738	80	7	a	a	DET
easat-3738	80	8	significantly	significantly	ADV
easat-3738	80	9	increased	increase	VERB
easat-3738	80	10	risk	risk	NOUN
easat-3738	80	11	of	of	ADP
easat-3738	80	12	both	both	CCONJ
easat-3738	80	13	muscular	muscular	ADJ
easat-3738	80	14	atrophy	atrophy	NOUN
easat-3738	80	15	and	and	CCONJ
easat-3738	80	16	impaired	impaired	ADJ
easat-3738	80	17	bone	bone	NOUN
easat-3738	80	18	density	density	NOUN
easat-3738	80	19	.	.	PUNCT
easat-3738	81	1	conversely	conversely	ADV
easat-3738	81	2	,	,	PUNCT
easat-3738	81	3	high	high	ADJ
easat-3738	81	4	levels	level	NOUN
easat-3738	81	5	of	of	ADP
easat-3738	81	6	physical	physical	ADJ
easat-3738	81	7	activity	activity	NOUN
easat-3738	81	8	might	might	AUX
easat-3738	81	9	cause	cause	VERB
easat-3738	81	10	the	the	DET
easat-3738	81	11	fracture	fracture	NOUN
easat-3738	81	12	site	site	NOUN
easat-3738	81	13	to	to	PART
easat-3738	81	14	become	become	VERB
easat-3738	81	15	more	more	ADV
easat-3738	81	16	stressful	stressful	ADJ
easat-3738	81	17	,	,	PUNCT
easat-3738	81	18	leading	lead	VERB
easat-3738	81	19	to	to	PART
easat-3738	81	20	delay	delay	VERB
easat-3738	81	21	in	in	ADP
easat-3738	81	22	healing	healing	NOUN
easat-3738	81	23	time	time	NOUN
easat-3738	81	24	.	.	PUNCT
easat-3738	82	1	optimum	optimum	ADJ
easat-3738	82	2	healing	healing	NOUN
easat-3738	82	3	occurs	occur	VERB
easat-3738	82	4	as	as	ADV
easat-3738	82	5	best	good	ADJ
easat-3738	82	6	when	when	SCONJ
easat-3738	82	7	the	the	DET
easat-3738	82	8	condition	condition	NOUN
easat-3738	82	9	of	of	ADP
easat-3738	82	10	patients	patient	NOUN
easat-3738	82	11	is	be	AUX
easat-3738	82	12	stable	stable	ADJ
easat-3738	82	13	and	and	CCONJ
easat-3738	82	14	balanced	balanced	ADJ
easat-3738	82	15	[	[	X
easat-3738	82	16	26	26	NUM
easat-3738	82	17	]	]	PUNCT
easat-3738	82	18	.	.	PUNCT
easat-3738	83	1	1.4.4	1.4.4	X
easat-3738	83	2	.	.	PUNCT
easat-3738	84	1	medical	medical	ADJ
easat-3738	84	2	conditions	condition	NOUN
easat-3738	84	3	chronic	chronic	VERB
easat-3738	84	4	high	high	ADJ
easat-3738	84	5	blood	blood	NOUN
easat-3738	84	6	sugar	sugar	NOUN
easat-3738	84	7	levels	level	NOUN
easat-3738	84	8	can	can	AUX
easat-3738	84	9	lead	lead	VERB
easat-3738	84	10	to	to	ADP
easat-3738	84	11	oxidative	oxidative	ADJ
easat-3738	84	12	stress	stress	NOUN
easat-3738	84	13	,	,	PUNCT
easat-3738	84	14	inflammatory	inflammatory	ADJ
easat-3738	84	15	reactions	reaction	NOUN
easat-3738	84	16	,	,	PUNCT
easat-3738	84	17	and	and	CCONJ
easat-3738	84	18	an	an	DET
easat-3738	84	19	imbalance	imbalance	NOUN
easat-3738	84	20	between	between	ADP
easat-3738	84	21	adipocytes	adipocyte	NOUN
easat-3738	84	22	and	and	CCONJ
easat-3738	84	23	osteocytes	osteocyte	VERB
easat-3738	84	24	formation	formation	NOUN
easat-3738	84	25	.	.	PUNCT
easat-3738	85	1	this	this	DET
easat-3738	85	2	condition	condition	NOUN
easat-3738	85	3	can	can	AUX
easat-3738	85	4	also	also	ADV
easat-3738	85	5	lead	lead	VERB
easat-3738	85	6	to	to	ADP
easat-3738	85	7	altering	alter	VERB
easat-3738	85	8	in	in	ADP
easat-3738	85	9	the	the	DET
easat-3738	85	10	signaling	signal	VERB
easat-3738	85	11	pathways	pathway	NOUN
easat-3738	85	12	and	and	CCONJ
easat-3738	85	13	bone	bone	NOUN
easat-3738	85	14	microvasculature	microvasculature	NOUN
easat-3738	85	15	[	[	X
easat-3738	85	16	27	27	NUM
easat-3738	85	17	]	]	PUNCT
easat-3738	85	18	.	.	PUNCT
easat-3738	86	1	the	the	DET
easat-3738	86	2	early	early	ADJ
easat-3738	86	3	accumulation	accumulation	NOUN
easat-3738	86	4	of	of	ADP
easat-3738	86	5	aging	age	VERB
easat-3738	86	6	cells	cell	NOUN
easat-3738	86	7	may	may	AUX
easat-3738	86	8	accelerate	accelerate	VERB
easat-3738	86	9	bone	bone	NOUN
easat-3738	86	10	aging	aging	NOUN
easat-3738	86	11	,	,	PUNCT
easat-3738	86	12	resulting	result	VERB
easat-3738	86	13	in	in	ADP
easat-3738	86	14	reduced	reduce	VERB
easat-3738	86	15	bone	bone	NOUN
easat-3738	86	16	strength	strength	NOUN
easat-3738	86	17	and	and	CCONJ
easat-3738	86	18	impaired	impaired	ADJ
easat-3738	86	19	bone	bone	NOUN
easat-3738	86	20	formation	formation	NOUN
easat-3738	87	1	[	[	X
easat-3738	87	2	28	28	NUM
easat-3738	87	3	]	]	PUNCT
easat-3738	87	4	.	.	PUNCT
easat-3738	88	1	furthermore	furthermore	ADV
easat-3738	88	2	,	,	PUNCT
easat-3738	88	3	high	high	ADJ
easat-3738	88	4	blood	blood	NOUN
easat-3738	88	5	sugar	sugar	NOUN
easat-3738	88	6	is	be	AUX
easat-3738	88	7	linked	link	VERB
easat-3738	88	8	to	to	ADP
easat-3738	88	9	the	the	DET
easat-3738	88	10	formation	formation	NOUN
easat-3738	88	11	of	of	ADP
easat-3738	88	12	advanced	advanced	ADJ
easat-3738	88	13	glycation	glycation	NOUN
easat-3738	88	14	end	end	NOUN
easat-3738	88	15	-	-	PUNCT
easat-3738	88	16	products	product	NOUN
easat-3738	88	17	(	(	PUNCT
easat-3738	88	18	ages	age	NOUN
easat-3738	88	19	)	)	PUNCT
easat-3738	88	20	,	,	PUNCT
easat-3738	88	21	which	which	PRON
easat-3738	88	22	play	play	VERB
easat-3738	88	23	important	important	ADJ
easat-3738	88	24	roles	role	NOUN
easat-3738	88	25	in	in	ADP
easat-3738	88	26	the	the	DET
easat-3738	88	27	impaired	impaired	ADJ
easat-3738	88	28	healing	healing	NOUN
easat-3738	88	29	of	of	ADP
easat-3738	88	30	bones	bone	NOUN
easat-3738	88	31	in	in	ADP
easat-3738	88	32	diabetic	diabetic	ADJ
easat-3738	88	33	patients	patient	NOUN
easat-3738	88	34	and	and	CCONJ
easat-3738	88	35	may	may	AUX
easat-3738	88	36	increase	increase	VERB
easat-3738	88	37	the	the	DET
easat-3738	88	38	risk	risk	NOUN
easat-3738	88	39	of	of	ADP
easat-3738	88	40	fractures	fracture	NOUN
easat-3738	88	41	in	in	ADP
easat-3738	88	42	type	type	NOUN
easat-3738	88	43	1	1	NUM
easat-3738	88	44	diabetes	diabetes	NOUN
easat-3738	88	45	mellitus	mellitus	NOUN
easat-3738	88	46	(	(	PUNCT
easat-3738	88	47	t1	t1	NOUN
easat-3738	88	48	dm	dm	PROPN
easat-3738	88	49	)	)	PUNCT
easat-3738	88	50	and	and	CCONJ
easat-3738	88	51	type	type	NOUN
easat-3738	88	52	2	2	NUM
easat-3738	88	53	diabetes	diabetes	NOUN
easat-3738	88	54	mellitus	mellitus	NOUN
easat-3738	88	55	(	(	PUNCT
easat-3738	88	56	t2	t2	NOUN
easat-3738	88	57	dm	dm	PROPN
easat-3738	88	58	)	)	PUNCT
easat-3738	89	1	[	[	X
easat-3738	89	2	27	27	NUM
easat-3738	89	3	-	-	SYM
easat-3738	89	4	31	31	NUM
easat-3738	89	5	]	]	PUNCT
easat-3738	89	6	.	.	PUNCT
easat-3738	90	1	therefore	therefore	ADV
easat-3738	90	2	,	,	PUNCT
easat-3738	90	3	managing	manage	VERB
easat-3738	90	4	these	these	DET
easat-3738	90	5	conditions	condition	NOUN
easat-3738	90	6	is	be	AUX
easat-3738	90	7	essential	essential	ADJ
easat-3738	90	8	alongside	alongside	ADP
easat-3738	90	9	treating	treat	VERB
easat-3738	90	10	fractures	fracture	NOUN
easat-3738	90	11	.	.	PUNCT
easat-3738	91	1	1.4.5	1.4.5	X
easat-3738	91	2	.	.	PUNCT
easat-3738	92	1	use	use	NOUN
easat-3738	92	2	of	of	ADP
easat-3738	92	3	medication	medication	NOUN
easat-3738	92	4	the	the	DET
easat-3738	92	5	use	use	NOUN
easat-3738	92	6	of	of	ADP
easat-3738	92	7	some	some	DET
easat-3738	92	8	commonly	commonly	ADV
easat-3738	92	9	prescribed	prescribe	VERB
easat-3738	92	10	medications	medication	NOUN
easat-3738	92	11	can	can	AUX
easat-3738	92	12	influence	influence	VERB
easat-3738	92	13	healing	healing	NOUN
easat-3738	92	14	.	.	PUNCT
easat-3738	93	1	non	non	ADJ
easat-3738	93	2	-	-	ADJ
easat-3738	93	3	steroid	steroid	ADJ
easat-3738	93	4	medications	medication	NOUN
easat-3738	93	5	for	for	ADP
easat-3738	93	6	example	example	NOUN
easat-3738	93	7	can	can	AUX
easat-3738	93	8	delay	delay	VERB
easat-3738	93	9	bone	bone	NOUN
easat-3738	93	10	repair	repair	NOUN
easat-3738	93	11	by	by	ADP
easat-3738	93	12	inhibiting	inhibit	VERB
easat-3738	93	13	cell	cell	NOUN
easat-3738	93	14	activity	activity	NOUN
easat-3738	93	15	and	and	CCONJ
easat-3738	93	16	impairing	impair	VERB
easat-3738	93	17	the	the	DET
easat-3738	93	18	granulated	granulate	VERB
easat-3738	93	19	tissue	tissue	NOUN
easat-3738	93	20	and	and	CCONJ
easat-3738	93	21	callus	callus	ADJ
easat-3738	93	22	formation	formation	NOUN
easat-3738	93	23	through	through	ADP
easat-3738	93	24	inhibiting	inhibit	VERB
easat-3738	93	25	the	the	DET
easat-3738	93	26	inflammatory	inflammatory	ADJ
easat-3738	93	27	response	response	NOUN
easat-3738	93	28	which	which	PRON
easat-3738	93	29	may	may	AUX
easat-3738	93	30	delay	delay	VERB
easat-3738	93	31	the	the	DET
easat-3738	93	32	bone	bone	NOUN
easat-3738	93	33	delay	delay	NOUN
easat-3738	93	34	[	[	X
easat-3738	93	35	32	32	NUM
easat-3738	93	36	]	]	PUNCT
easat-3738	93	37	.	.	PUNCT
easat-3738	94	1	hence	hence	ADV
easat-3738	94	2	the	the	DET
easat-3738	94	3	consideration	consideration	NOUN
easat-3738	94	4	of	of	ADP
easat-3738	94	5	a	a	DET
easat-3738	94	6	patient	patient	NOUN
easat-3738	94	7	's	's	PART
easat-3738	94	8	medication	medication	NOUN
easat-3738	94	9	history	history	NOUN
easat-3738	94	10	is	be	AUX
easat-3738	94	11	important	important	ADJ
easat-3738	94	12	in	in	ADP
easat-3738	94	13	the	the	DET
easat-3738	94	14	formulation	formulation	NOUN
easat-3738	94	15	of	of	ADP
easat-3738	94	16	treatment	treatment	NOUN
easat-3738	94	17	plans	plan	NOUN
easat-3738	94	18	.	.	PUNCT
easat-3738	95	1	1.4.6	1.4.6	X
easat-3738	95	2	.	.	PUNCT
easat-3738	95	3	smoking	smoking	NOUN
easat-3738	95	4	smoking	smoking	NOUN
easat-3738	95	5	is	be	AUX
easat-3738	95	6	known	know	VERB
easat-3738	95	7	to	to	PART
easat-3738	95	8	prolong	prolong	VERB
easat-3738	95	9	the	the	DET
easat-3738	95	10	healing	healing	NOUN
easat-3738	95	11	process	process	NOUN
easat-3738	95	12	.	.	PUNCT
easat-3738	96	1	nicotine	nicotine	NOUN
easat-3738	96	2	and	and	CCONJ
easat-3738	96	3	other	other	ADJ
easat-3738	96	4	chemicals	chemical	NOUN
easat-3738	96	5	in	in	ADP
easat-3738	96	6	tobacco	tobacco	NOUN
easat-3738	96	7	smoke	smoke	NOUN
easat-3738	96	8	reduce	reduce	VERB
easat-3738	96	9	blood	blood	NOUN
easat-3738	96	10	flow	flow	NOUN
easat-3738	96	11	to	to	ADP
easat-3738	96	12	the	the	DET
easat-3738	96	13	bones	bone	NOUN
easat-3738	96	14	[	[	X
easat-3738	96	15	33	33	NUM
easat-3738	96	16	]	]	PUNCT
easat-3738	96	17	.	.	PUNCT
easat-3738	97	1	this	this	PRON
easat-3738	97	2	significantly	significantly	ADV
easat-3738	97	3	decreases	decrease	VERB
easat-3738	97	4	the	the	DET
easat-3738	97	5	nutrients	nutrient	NOUN
easat-3738	97	6	and	and	CCONJ
easat-3738	97	7	oxygen	oxygen	NOUN
easat-3738	97	8	required	require	VERB
easat-3738	97	9	for	for	ADP
easat-3738	97	10	proper	proper	ADJ
easat-3738	97	11	healing	healing	NOUN
easat-3738	97	12	and	and	CCONJ
easat-3738	97	13	consequently	consequently	ADV
easat-3738	97	14	delay	delay	VERB
easat-3738	97	15	in	in	ADP
easat-3738	97	16	the	the	DET
easat-3738	97	17	healing	healing	NOUN
easat-3738	97	18	capacity	capacity	NOUN
easat-3738	97	19	[	[	X
easat-3738	97	20	34	34	NUM
easat-3738	97	21	]	]	PUNCT
easat-3738	97	22	.	.	PUNCT
easat-3738	98	1	therefore	therefore	ADV
easat-3738	98	2	,	,	PUNCT
easat-3738	98	3	quitting	quit	VERB
easat-3738	98	4	smoking	smoking	NOUN
easat-3738	98	5	is	be	AUX
easat-3738	98	6	essential	essential	ADJ
easat-3738	98	7	for	for	ADP
easat-3738	98	8	optimal	optimal	ADJ
easat-3738	98	9	fracture	fracture	NOUN
easat-3738	98	10	healing	healing	NOUN
easat-3738	98	11	.	.	PUNCT
easat-3738	99	1	1.4.7	1.4.7	NOUN
easat-3738	99	2	.	.	PUNCT
easat-3738	99	3	biomechanical	biomechanical	ADJ
easat-3738	99	4	environment	environment	NOUN
easat-3738	99	5	the	the	DET
easat-3738	99	6	significance	significance	NOUN
easat-3738	99	7	of	of	ADP
easat-3738	99	8	the	the	DET
easat-3738	99	9	stability	stability	NOUN
easat-3738	99	10	of	of	ADP
easat-3738	99	11	the	the	DET
easat-3738	99	12	fracture	fracture	NOUN
easat-3738	99	13	greatly	greatly	ADV
easat-3738	99	14	affects	affect	VERB
easat-3738	99	15	the	the	DET
easat-3738	99	16	healing	healing	NOUN
easat-3738	99	17	.	.	PUNCT
easat-3738	100	1	healing	heal	VERB
easat-3738	100	2	with	with	ADP
easat-3738	100	3	rigidity	rigidity	NOUN
easat-3738	100	4	stabilization	stabilization	NOUN
easat-3738	100	5	occurs	occur	VERB
easat-3738	100	6	in	in	ADP
easat-3738	100	7	primary	primary	ADJ
easat-3738	100	8	healing	healing	NOUN
easat-3738	100	9	[	[	X
easat-3738	100	10	35	35	NUM
easat-3738	100	11	,	,	PUNCT
easat-3738	100	12	36	36	NUM
easat-3738	100	13	]	]	PUNCT
easat-3738	100	14	.	.	PUNCT
easat-3738	101	1	whereas	whereas	SCONJ
easat-3738	101	2	healing	heal	VERB
easat-3738	101	3	in	in	ADP
easat-3738	101	4	the	the	DET
easat-3738	101	5	secondary	secondary	ADJ
easat-3738	101	6	fracture	fracture	NOUN
easat-3738	101	7	type	type	NOUN
easat-3738	101	8	needs	need	VERB
easat-3738	101	9	some	some	DET
easat-3738	101	10	motion	motion	NOUN
easat-3738	101	11	to	to	PART
easat-3738	101	12	enhance	enhance	VERB
easat-3738	101	13	callus	callus	ADJ
easat-3738	101	14	formation	formation	NOUN
easat-3738	101	15	[	[	X
easat-3738	101	16	37	37	NUM
easat-3738	101	17	,	,	PUNCT
easat-3738	101	18	38	38	NUM
easat-3738	101	19	]	]	PUNCT
easat-3738	101	20	.	.	PUNCT
easat-3738	102	1	1.4.8	1.4.8	NUM
easat-3738	102	2	.	.	X
easat-3738	102	3	cellular	cellular	ADJ
easat-3738	102	4	mechanisms	mechanism	NOUN
easat-3738	102	5	various	various	ADJ
easat-3738	102	6	skeletal	skeletal	ADJ
easat-3738	102	7	cells	cell	NOUN
easat-3738	102	8	and	and	CCONJ
easat-3738	102	9	biochemical	biochemical	ADJ
easat-3738	102	10	factors	factor	NOUN
easat-3738	102	11	play	play	VERB
easat-3738	102	12	essential	essential	ADJ
easat-3738	102	13	roles	role	NOUN
easat-3738	102	14	in	in	ADP
easat-3738	102	15	the	the	DET
easat-3738	102	16	healing	healing	NOUN
easat-3738	102	17	process	process	NOUN
easat-3738	102	18	,	,	PUNCT
easat-3738	102	19	influencing	influence	VERB
easat-3738	102	20	outcomes	outcome	NOUN
easat-3738	102	21	and	and	CCONJ
easat-3738	102	22	potential	potential	ADJ
easat-3738	102	23	complications	complication	NOUN
easat-3738	102	24	.	.	PUNCT
easat-3738	103	1	[	[	X
easat-3738	103	2	39	39	NUM
easat-3738	103	3	]	]	PUNCT
easat-3738	103	4	.	.	PUNCT
easat-3738	104	1	bone	bone	NOUN
easat-3738	104	2	fracture	fracture	NOUN
easat-3738	104	3	healing	healing	NOUN
easat-3738	104	4	is	be	AUX
easat-3738	104	5	a	a	DET
easat-3738	104	6	complex	complex	ADJ
easat-3738	104	7	physiological	physiological	ADJ
easat-3738	104	8	process	process	NOUN
easat-3738	104	9	that	that	PRON
easat-3738	104	10	involves	involve	VERB
easat-3738	104	11	multiple	multiple	ADJ
easat-3738	104	12	stages	stage	NOUN
easat-3738	104	13	and	and	CCONJ
easat-3738	104	14	factors	factor	NOUN
easat-3738	104	15	.	.	PUNCT
easat-3738	105	1	understanding	understand	VERB
easat-3738	105	2	these	these	DET
easat-3738	105	3	stages	stage	NOUN
easat-3738	105	4	is	be	AUX
easat-3738	105	5	crucial	crucial	ADJ
easat-3738	105	6	for	for	ADP
easat-3738	105	7	effective	effective	ADJ
easat-3738	105	8	treatment	treatment	NOUN
easat-3738	105	9	and	and	CCONJ
easat-3738	105	10	management	management	NOUN
easat-3738	105	11	of	of	ADP
easat-3738	105	12	fractures	fracture	NOUN
easat-3738	105	13	.	.	PUNCT
easat-3738	106	1	1.4.9	1.4.9	NUM
easat-3738	106	2	.	.	PUNCT
easat-3738	107	1	role	role	NOUN
easat-3738	107	2	of	of	ADP
easat-3738	107	3	specific	specific	ADJ
easat-3738	107	4	immune	immune	ADJ
easat-3738	107	5	cells	cell	NOUN
easat-3738	107	6	in	in	ADP
easat-3738	107	7	bone	bone	NOUN
easat-3738	107	8	healing	heal	VERB
easat-3738	107	9	certain	certain	ADJ
easat-3738	107	10	immune	immune	ADJ
easat-3738	107	11	cells	cell	NOUN
easat-3738	107	12	,	,	PUNCT
easat-3738	107	13	specifically	specifically	ADV
easat-3738	107	14	macrophages	macrophage	NOUN
easat-3738	107	15	and	and	CCONJ
easat-3738	107	16	t	t	NOUN
easat-3738	107	17	-	-	PUNCT
easat-3738	107	18	cells	cell	NOUN
easat-3738	107	19	,	,	PUNCT
easat-3738	107	20	are	be	AUX
easat-3738	107	21	particularly	particularly	ADV
easat-3738	107	22	important	important	ADJ
easat-3738	107	23	.	.	PUNCT
easat-3738	108	1	macrophages	macrophage	NOUN
easat-3738	108	2	help	help	VERB
easat-3738	108	3	clear	clear	ADJ
easat-3738	108	4	debris	debris	NOUN
easat-3738	108	5	and	and	CCONJ
easat-3738	108	6	secrete	secrete	NOUN
easat-3738	108	7	factors	factor	NOUN
easat-3738	108	8	that	that	PRON
easat-3738	108	9	promote	promote	VERB
easat-3738	108	10	tissue	tissue	NOUN
easat-3738	108	11	repair	repair	NOUN
easat-3738	108	12	[	[	X
easat-3738	108	13	40	40	NUM
easat-3738	108	14	]	]	PUNCT
easat-3738	108	15	.	.	PUNCT
easat-3738	109	1	t	t	NOUN
easat-3738	109	2	-	-	PUNCT
easat-3738	109	3	cells	cell	NOUN
easat-3738	109	4	,	,	PUNCT
easat-3738	109	5	especially	especially	ADV
easat-3738	109	6	cd8	cd8	PROPN
easat-3738	109	7	+	+	PROPN
easat-3738	109	8	t	t	PROPN
easat-3738	109	9	-	-	PUNCT
easat-3738	109	10	cells	cell	NOUN
easat-3738	109	11	,	,	PUNCT
easat-3738	109	12	can	can	AUX
easat-3738	109	13	influence	influence	VERB
easat-3738	109	14	the	the	DET
easat-3738	109	15	healing	healing	NOUN
easat-3738	109	16	process	process	NOUN
easat-3738	109	17	,	,	PUNCT
easat-3738	109	18	whereas	whereas	SCONJ
easat-3738	109	19	those	those	DET
easat-3738	109	20	cells	cell	NOUN
easat-3738	109	21	negatively	negatively	ADV
easat-3738	109	22	impact	impact	VERB
easat-3738	109	23	bone	bone	NOUN
easat-3738	109	24	healing	healing	NOUN
easat-3738	109	25	if	if	SCONJ
easat-3738	109	26	they	they	PRON
easat-3738	109	27	misinterpret	misinterpret	VERB
easat-3738	109	28	the	the	DET
easat-3738	109	29	fracture	fracture	NOUN
easat-3738	109	30	as	as	ADP
easat-3738	109	31	an	an	DET
easat-3738	109	32	infection	infection	NOUN
easat-3738	109	33	and	and	CCONJ
easat-3738	109	34	release	release	VERB
easat-3738	109	35	inflammatory	inflammatory	ADJ
easat-3738	109	36	cytokines	cytokine	NOUN
easat-3738	109	37	[	[	X
easat-3738	109	38	41	41	NUM
easat-3738	109	39	]	]	PUNCT
easat-3738	109	40	.	.	PUNCT
easat-3738	110	1	2540	2540	NUM
easat-3738	110	2	edelweiss	edelweiss	PROPN
easat-3738	110	3	applied	apply	VERB
easat-3738	110	4	science	science	NOUN
easat-3738	110	5	and	and	CCONJ
easat-3738	110	6	technology	technology	NOUN
easat-3738	110	7	issn	issn	PROPN
easat-3738	110	8	:	:	PUNCT
easat-3738	110	9	2576	2576	NUM
easat-3738	110	10	-	-	SYM
easat-3738	110	11	8484	8484	NUM
easat-3738	110	12	vol	vol	NOUN
easat-3738	110	13	.	.	PROPN
easat-3738	110	14	8	8	NUM
easat-3738	110	15	,	,	PUNCT
easat-3738	110	16	no	no	INTJ
easat-3738	110	17	.	.	NOUN
easat-3738	110	18	5	5	NUM
easat-3738	110	19	:	:	SYM
easat-3738	110	20	2536	2536	NUM
easat-3738	110	21	-	-	SYM
easat-3738	110	22	2541	2541	NUM
easat-3738	110	23	,	,	PUNCT
easat-3738	110	24	2024	2024	NUM
easat-3738	110	25	doi	doi	NOUN
easat-3738	110	26	:	:	PUNCT
easat-3738	110	27	10.55214/25768484.v8i6.3738	10.55214/25768484.v8i6.3738	NUM
easat-3738	110	28	©	©	NOUN
easat-3738	110	29	2024	2024	NUM
easat-3738	110	30	by	by	ADP
easat-3738	110	31	the	the	DET
easat-3738	110	32	authors	author	NOUN
easat-3738	110	33	;	;	PUNCT
easat-3738	110	34	licensee	licensee	PROPN
easat-3738	110	35	learning	learn	VERB
easat-3738	110	36	gate	gate	PROPN
easat-3738	110	37	1.4.10	1.4.10	NUM
easat-3738	110	38	.	.	PUNCT
easat-3738	111	1	balanced	balanced	ADJ
easat-3738	111	2	immune	immune	ADJ
easat-3738	111	3	response	response	NOUN
easat-3738	111	4	the	the	DET
easat-3738	111	5	balanced	balanced	ADJ
easat-3738	111	6	immune	immune	ADJ
easat-3738	111	7	response	response	NOUN
easat-3738	111	8	is	be	AUX
easat-3738	111	9	very	very	ADV
easat-3738	111	10	important	important	ADJ
easat-3738	111	11	for	for	ADP
easat-3738	111	12	effective	effective	ADJ
easat-3738	111	13	bone	bone	NOUN
easat-3738	111	14	healing	healing	NOUN
easat-3738	111	15	,	,	PUNCT
easat-3738	111	16	it	it	PRON
easat-3738	111	17	should	should	AUX
easat-3738	111	18	in	in	ADP
easat-3738	111	19	the	the	DET
easat-3738	111	20	optimum	optimum	ADJ
easat-3738	111	21	manner	manner	NOUN
easat-3738	111	22	,	,	PUNCT
easat-3738	111	23	attenuated	attenuate	VERB
easat-3738	111	24	or	or	CCONJ
easat-3738	111	25	too	too	ADV
easat-3738	111	26	much	much	ADV
easat-3738	111	27	active	active	ADJ
easat-3738	111	28	immune	immune	ADJ
easat-3738	111	29	responses	response	NOUN
easat-3738	111	30	affect	affect	VERB
easat-3738	111	31	the	the	DET
easat-3738	111	32	healing	healing	NOUN
easat-3738	111	33	negatively	negatively	ADV
easat-3738	111	34	,	,	PUNCT
easat-3738	111	35	for	for	ADP
easat-3738	111	36	example	example	NOUN
easat-3738	111	37	hiv	hiv	PROPN
easat-3738	111	38	patients	patient	NOUN
easat-3738	111	39	with	with	ADP
easat-3738	111	40	bone	bone	NOUN
easat-3738	111	41	fractures	fracture	NOUN
easat-3738	111	42	show	show	VERB
easat-3738	111	43	low	low	ADJ
easat-3738	111	44	rate	rate	NOUN
easat-3738	111	45	of	of	ADP
easat-3738	111	46	healing	healing	NOUN
easat-3738	111	47	[	[	X
easat-3738	111	48	6	6	NUM
easat-3738	111	49	,	,	PUNCT
easat-3738	111	50	42	42	NUM
easat-3738	111	51	]	]	PUNCT
easat-3738	111	52	.	.	PUNCT
easat-3738	112	1	on	on	ADP
easat-3738	112	2	the	the	DET
easat-3738	112	3	other	other	ADJ
easat-3738	112	4	hand	hand	NOUN
easat-3738	112	5	,	,	PUNCT
easat-3738	112	6	patients	patient	NOUN
easat-3738	112	7	with	with	ADP
easat-3738	112	8	autoimmune	autoimmune	ADJ
easat-3738	112	9	diseases	disease	NOUN
easat-3738	112	10	with	with	ADP
easat-3738	112	11	high	high	ADJ
easat-3738	112	12	level	level	NOUN
easat-3738	112	13	of	of	ADP
easat-3738	112	14	inflammatory	inflammatory	ADJ
easat-3738	112	15	response	response	NOUN
easat-3738	112	16	such	such	ADJ
easat-3738	112	17	as	as	ADP
easat-3738	112	18	rheumatoid	rheumatoid	NOUN
easat-3738	112	19	arthritis	arthritis	NOUN
easat-3738	112	20	are	be	AUX
easat-3738	112	21	suffering	suffer	VERB
easat-3738	112	22	from	from	ADP
easat-3738	112	23	inhibition	inhibition	NOUN
easat-3738	112	24	of	of	ADP
easat-3738	112	25	the	the	DET
easat-3738	112	26	bone	bone	NOUN
easat-3738	112	27	fracture	fracture	NOUN
easat-3738	112	28	healing	healing	NOUN
easat-3738	112	29	[	[	X
easat-3738	112	30	43	43	NUM
easat-3738	112	31	,	,	PUNCT
easat-3738	112	32	44	44	NUM
easat-3738	112	33	]	]	PUNCT
easat-3738	112	34	.	.	PUNCT
easat-3738	113	1	in	in	ADP
easat-3738	113	2	diabetic	diabetic	ADJ
easat-3738	113	3	patients	patient	NOUN
easat-3738	113	4	who	who	PRON
easat-3738	113	5	have	have	VERB
easat-3738	113	6	a	a	DET
easat-3738	113	7	chronic	chronic	ADJ
easat-3738	113	8	high	high	ADJ
easat-3738	113	9	level	level	NOUN
easat-3738	113	10	of	of	ADP
easat-3738	113	11	inflammation	inflammation	NOUN
easat-3738	113	12	and	and	CCONJ
easat-3738	113	13	increased	increase	VERB
easat-3738	113	14	tnfα	tnfα	NOUN
easat-3738	113	15	with	with	ADP
easat-3738	113	16	increasing	increase	VERB
easat-3738	113	17	the	the	DET
easat-3738	113	18	apoptotic	apoptotic	ADJ
easat-3738	113	19	activity	activity	NOUN
easat-3738	113	20	of	of	ADP
easat-3738	113	21	the	the	DET
easat-3738	113	22	cartilage	cartilage	NOUN
easat-3738	113	23	forming	form	VERB
easat-3738	113	24	cells	cell	NOUN
easat-3738	113	25	,	,	PUNCT
easat-3738	113	26	thus	thus	ADV
easat-3738	113	27	leading	lead	VERB
easat-3738	113	28	to	to	ADP
easat-3738	113	29	the	the	DET
easat-3738	113	30	disappearing	disappearing	NOUN
easat-3738	113	31	of	of	ADP
easat-3738	113	32	the	the	DET
easat-3738	113	33	formed	form	VERB
easat-3738	113	34	cartilaginous	cartilaginous	ADJ
easat-3738	113	35	callus	callus	NOUN
easat-3738	113	36	at	at	ADP
easat-3738	113	37	the	the	DET
easat-3738	113	38	site	site	NOUN
easat-3738	113	39	of	of	ADP
easat-3738	113	40	the	the	DET
easat-3738	113	41	fractures	fracture	NOUN
easat-3738	113	42	and	and	CCONJ
easat-3738	113	43	hence	hence	ADV
easat-3738	113	44	,	,	PUNCT
easat-3738	113	45	failing	fail	VERB
easat-3738	113	46	of	of	ADP
easat-3738	113	47	the	the	DET
easat-3738	113	48	fracture	fracture	NOUN
easat-3738	113	49	healing	healing	NOUN
easat-3738	113	50	[	[	PUNCT
easat-3738	113	51	45	45	NUM
easat-3738	113	52	-	-	SYM
easat-3738	113	53	47	47	NUM
easat-3738	113	54	]	]	PUNCT
easat-3738	113	55	.	.	PUNCT
easat-3738	114	1	2	2	X
easat-3738	114	2	.	.	X
easat-3738	114	3	conclusion	conclusion	NOUN
easat-3738	114	4	the	the	DET
easat-3738	114	5	immunity	immunity	NOUN
easat-3738	114	6	of	of	ADP
easat-3738	114	7	the	the	DET
easat-3738	114	8	body	body	NOUN
easat-3738	114	9	is	be	AUX
easat-3738	114	10	a	a	DET
easat-3738	114	11	key	key	ADJ
easat-3738	114	12	factor	factor	NOUN
easat-3738	114	13	in	in	ADP
easat-3738	114	14	the	the	DET
easat-3738	114	15	process	process	NOUN
easat-3738	114	16	of	of	ADP
easat-3738	114	17	bone	bone	NOUN
easat-3738	114	18	fracture	fracture	NOUN
easat-3738	114	19	healing	healing	NOUN
easat-3738	114	20	,	,	PUNCT
easat-3738	114	21	healthy	healthy	ADJ
easat-3738	114	22	patients	patient	NOUN
easat-3738	114	23	with	with	ADP
easat-3738	114	24	normal	normal	ADJ
easat-3738	114	25	and	and	CCONJ
easat-3738	114	26	balanced	balanced	ADJ
easat-3738	114	27	immune	immune	ADJ
easat-3738	114	28	response	response	NOUN
easat-3738	114	29	showed	show	VERB
easat-3738	114	30	normal	normal	ADJ
easat-3738	114	31	rates	rate	NOUN
easat-3738	114	32	of	of	ADP
easat-3738	114	33	fracture	fracture	NOUN
easat-3738	114	34	healing	healing	NOUN
easat-3738	114	35	.	.	PUNCT
easat-3738	115	1	on	on	ADP
easat-3738	115	2	the	the	DET
easat-3738	115	3	other	other	ADJ
easat-3738	115	4	hand	hand	NOUN
easat-3738	115	5	,	,	PUNCT
easat-3738	115	6	those	those	PRON
easat-3738	115	7	with	with	ADP
easat-3738	115	8	over	over	ADP
easat-3738	115	9	expressed	express	VERB
easat-3738	115	10	inflammatory	inflammatory	ADJ
easat-3738	115	11	immune	immune	ADJ
easat-3738	115	12	response	response	NOUN
easat-3738	115	13	or	or	CCONJ
easat-3738	115	14	immunocompromised	immunocompromise	VERB
easat-3738	115	15	patients	patient	NOUN
easat-3738	115	16	may	may	AUX
easat-3738	115	17	show	show	VERB
easat-3738	115	18	delay	delay	NOUN
easat-3738	115	19	or	or	CCONJ
easat-3738	115	20	inhibition	inhibition	NOUN
easat-3738	115	21	in	in	ADP
easat-3738	115	22	the	the	DET
easat-3738	115	23	fracture	fracture	NOUN
easat-3738	115	24	healing	healing	NOUN
easat-3738	115	25	.	.	PUNCT
easat-3738	116	1	thus	thus	ADV
easat-3738	116	2	,	,	PUNCT
easat-3738	116	3	understanding	understand	VERB
easat-3738	116	4	the	the	DET
easat-3738	116	5	roles	role	NOUN
easat-3738	116	6	of	of	ADP
easat-3738	116	7	the	the	DET
easat-3738	116	8	inflammatory	inflammatory	ADJ
easat-3738	116	9	immune	immune	ADJ
easat-3738	116	10	response	response	NOUN
easat-3738	116	11	in	in	ADP
easat-3738	116	12	bone	bone	NOUN
easat-3738	116	13	healing	healing	NOUN
easat-3738	116	14	can	can	AUX
easat-3738	116	15	help	help	VERB
easat-3738	116	16	in	in	ADP
easat-3738	116	17	developing	develop	VERB
easat-3738	116	18	successful	successful	ADJ
easat-3738	116	19	therapy	therapy	NOUN
easat-3738	116	20	to	to	PART
easat-3738	116	21	improve	improve	VERB
easat-3738	116	22	fracture	fracture	NOUN
easat-3738	116	23	healing	heal	VERB
easat-3738	116	24	outcomes	outcome	NOUN
easat-3738	116	25	.	.	PUNCT
easat-3738	117	1	acknowledgement	acknowledgement	NOUN
easat-3738	117	2	:	:	PUNCT
easat-3738	117	3	the	the	DET
easat-3738	117	4	authors	author	NOUN
easat-3738	117	5	extend	extend	VERB
easat-3738	117	6	their	their	PRON
easat-3738	117	7	appreciation	appreciation	NOUN
easat-3738	117	8	to	to	ADP
easat-3738	117	9	the	the	DET
easat-3738	117	10	deanship	deanship	NOUN
easat-3738	117	11	of	of	ADP
easat-3738	117	12	scientific	scientific	ADJ
easat-3738	117	13	research	research	NOUN
easat-3738	117	14	at	at	ADP
easat-3738	117	15	northern	northern	ADJ
easat-3738	117	16	border	border	NOUN
easat-3738	117	17	university	university	PROPN
easat-3738	117	18	,	,	PUNCT
easat-3738	117	19	arar	arar	PROPN
easat-3738	117	20	,	,	PUNCT
easat-3738	117	21	saudi	saudi	PROPN
easat-3738	117	22	arabia	arabia	PROPN
easat-3738	117	23	.	.	PUNCT
easat-3738	118	1	copyright	copyright	NOUN
easat-3738	118	2	:	:	PUNCT
easat-3738	118	3	©	©	PROPN
easat-3738	118	4	2024	2024	NUM
easat-3738	118	5	by	by	ADP
easat-3738	118	6	the	the	DET
easat-3738	118	7	authors	author	NOUN
easat-3738	118	8	.	.	PUNCT
easat-3738	119	1	this	this	DET
easat-3738	119	2	article	article	NOUN
easat-3738	119	3	is	be	AUX
easat-3738	119	4	an	an	DET
easat-3738	119	5	open	open	ADJ
easat-3738	119	6	access	access	NOUN
easat-3738	119	7	article	article	NOUN
easat-3738	119	8	distributed	distribute	VERB
easat-3738	119	9	under	under	ADP
easat-3738	119	10	the	the	DET
easat-3738	119	11	terms	term	NOUN
easat-3738	119	12	and	and	CCONJ
easat-3738	119	13	conditions	condition	NOUN
easat-3738	119	14	of	of	ADP
easat-3738	119	15	the	the	DET
easat-3738	119	16	creative	creative	ADJ
easat-3738	119	17	commons	common	NOUN
easat-3738	119	18	attribution	attribution	NOUN
easat-3738	119	19	(	(	PUNCT
easat-3738	119	20	cc	cc	NOUN
easat-3738	119	21	by	by	ADP
easat-3738	119	22	)	)	PUNCT
easat-3738	119	23	license	license	NOUN
easat-3738	119	24	(	(	PUNCT
easat-3738	119	25	https://creativecommons.org/licenses/by/4.0/	https://creativecommons.org/licenses/by/4.0/	PROPN
easat-3738	119	26	)	)	PUNCT
easat-3738	119	27	.	.	PUNCT
easat-3738	120	1	references	reference	NOUN
easat-3738	120	2	[	[	X
easat-3738	120	3	1	1	NUM
easat-3738	120	4	]	]	PUNCT
easat-3738	120	5	toosi	toosi	NOUN
easat-3738	120	6	,	,	PUNCT
easat-3738	120	7	s.	s.	PROPN
easat-3738	120	8	,	,	PUNCT
easat-3738	120	9	et	et	PROPN
easat-3738	120	10	al	al	PROPN
easat-3738	120	11	.	.	PROPN
easat-3738	120	12	,	,	PUNCT
easat-3738	120	13	additively	additively	ADV
easat-3738	120	14	manufactured	manufacture	VERB
easat-3738	120	15	porous	porous	ADJ
easat-3738	120	16	scaffolds	scaffold	NOUN
easat-3738	120	17	by	by	ADP
easat-3738	120	18	design	design	NOUN
easat-3738	120	19	for	for	ADP
easat-3738	120	20	treatment	treatment	NOUN
easat-3738	120	21	of	of	ADP
easat-3738	120	22	bone	bone	NOUN
easat-3738	120	23	defects	defect	NOUN
easat-3738	120	24	.	.	PUNCT
easat-3738	121	1	frontiers	frontier	NOUN
easat-3738	121	2	in	in	ADP
easat-3738	121	3	bioengineering	bioengineering	NOUN
easat-3738	121	4	and	and	CCONJ
easat-3738	121	5	biotechnology	biotechnology	NOUN
easat-3738	121	6	,	,	PUNCT
easat-3738	121	7	2024	2024	NUM
easat-3738	121	8	.	.	PUNCT
easat-3738	122	1	11	11	NUM
easat-3738	122	2	:	:	PUNCT
easat-3738	123	1	p.	p.	NOUN
easat-3738	123	2	1252636	1252636	NUM
easat-3738	123	3	.	.	PUNCT
easat-3738	124	1	[	[	X
easat-3738	124	2	2	2	NUM
easat-3738	124	3	]	]	X
easat-3738	124	4	amin	amin	NOUN
easat-3738	124	5	,	,	PUNCT
easat-3738	124	6	s.	s.	PROPN
easat-3738	124	7	,	,	PUNCT
easat-3738	124	8	et	et	PROPN
easat-3738	124	9	al	al	PROPN
easat-3738	124	10	.	.	PROPN
easat-3738	124	11	,	,	PUNCT
easat-3738	124	12	trends	trend	NOUN
easat-3738	124	13	in	in	ADP
easat-3738	124	14	fracture	fracture	ADJ
easat-3738	124	15	incidence	incidence	NOUN
easat-3738	124	16	:	:	PUNCT
easat-3738	124	17	a	a	DET
easat-3738	124	18	population‐based	population‐base	VERB
easat-3738	124	19	study	study	NOUN
easat-3738	124	20	over	over	ADP
easat-3738	124	21	20	20	NUM
easat-3738	124	22	years	year	NOUN
easat-3738	124	23	.	.	PUNCT
easat-3738	125	1	journal	journal	NOUN
easat-3738	125	2	of	of	ADP
easat-3738	125	3	bone	bone	NOUN
easat-3738	125	4	and	and	CCONJ
easat-3738	125	5	mineral	mineral	NOUN
easat-3738	125	6	research	research	NOUN
easat-3738	125	7	,	,	PUNCT
easat-3738	125	8	2014	2014	NUM
easat-3738	125	9	.	.	PUNCT
easat-3738	126	1	29(3	29(3	NUM
easat-3738	126	2	):	):	PUNCT
easat-3738	126	3	p.	p.	NOUN
easat-3738	126	4	581	581	NUM
easat-3738	126	5	-	-	SYM
easat-3738	126	6	589	589	NUM
easat-3738	126	7	.	.	PUNCT
easat-3738	127	1	[	[	X
easat-3738	127	2	3	3	NUM
easat-3738	127	3	]	]	X
easat-3738	127	4	bergh	bergh	PROPN
easat-3738	127	5	,	,	PUNCT
easat-3738	127	6	c.	c.	PROPN
easat-3738	127	7	,	,	PUNCT
easat-3738	127	8	et	et	PROPN
easat-3738	127	9	al	al	PROPN
easat-3738	127	10	.	.	PROPN
easat-3738	127	11	,	,	PUNCT
easat-3738	127	12	fracture	fracture	ADJ
easat-3738	127	13	incidence	incidence	NOUN
easat-3738	127	14	in	in	ADP
easat-3738	127	15	adults	adult	NOUN
easat-3738	127	16	in	in	ADP
easat-3738	127	17	relation	relation	NOUN
easat-3738	127	18	to	to	ADP
easat-3738	127	19	age	age	NOUN
easat-3738	127	20	and	and	CCONJ
easat-3738	127	21	gender	gender	NOUN
easat-3738	127	22	:	:	PUNCT
easat-3738	127	23	a	a	DET
easat-3738	127	24	study	study	NOUN
easat-3738	127	25	of	of	ADP
easat-3738	127	26	27,169	27,169	NUM
easat-3738	127	27	fractures	fracture	NOUN
easat-3738	127	28	in	in	ADP
easat-3738	127	29	the	the	DET
easat-3738	127	30	swedish	swedish	ADJ
easat-3738	127	31	fracture	fracture	PROPN
easat-3738	127	32	register	register	VERB
easat-3738	127	33	in	in	ADP
easat-3738	127	34	a	a	DET
easat-3738	127	35	well	well	ADV
easat-3738	127	36	-	-	PUNCT
easat-3738	127	37	defined	define	VERB
easat-3738	127	38	catchment	catchment	NOUN
easat-3738	127	39	area	area	NOUN
easat-3738	127	40	.	.	PUNCT
easat-3738	128	1	plos	plos	PROPN
easat-3738	128	2	one	one	NUM
easat-3738	128	3	,	,	PUNCT
easat-3738	128	4	2020	2020	NUM
easat-3738	128	5	.	.	PUNCT
easat-3738	129	1	15(12	15(12	NUM
easat-3738	129	2	):	):	PUNCT
easat-3738	129	3	p.	p.	PROPN
easat-3738	129	4	e0244291	e0244291	PROPN
easat-3738	129	5	.	.	PUNCT
easat-3738	130	1	[	[	X
easat-3738	130	2	4	4	NUM
easat-3738	130	3	]	]	X
easat-3738	130	4	eiff	eiff	ADJ
easat-3738	130	5	,	,	PUNCT
easat-3738	130	6	m.p	m.p	PROPN
easat-3738	130	7	.	.	PROPN
easat-3738	130	8	and	and	CCONJ
easat-3738	130	9	r.l	r.l	PROPN
easat-3738	130	10	.	.	PROPN
easat-3738	130	11	hatch	hatch	PROPN
easat-3738	130	12	,	,	PUNCT
easat-3738	130	13	fracture	fracture	NOUN
easat-3738	130	14	management	management	NOUN
easat-3738	130	15	for	for	ADP
easat-3738	130	16	primary	primary	ADJ
easat-3738	130	17	care	care	NOUN
easat-3738	130	18	and	and	CCONJ
easat-3738	130	19	emergency	emergency	NOUN
easat-3738	130	20	medicine	medicine	NOUN
easat-3738	130	21	.	.	PUNCT
easat-3738	131	1	2018	2018	NUM
easat-3738	131	2	:	:	PUNCT
easat-3738	131	3	elsevier	elsevier	PROPN
easat-3738	131	4	health	health	PROPN
easat-3738	131	5	sciences	sciences	PROPN
easat-3738	131	6	.	.	PUNCT
easat-3738	132	1	[	[	X
easat-3738	132	2	5	5	NUM
easat-3738	132	3	]	]	X
easat-3738	132	4	wilkins	wilkins	PROPN
easat-3738	132	5	,	,	PUNCT
easat-3738	132	6	k.e	k.e	PROPN
easat-3738	132	7	.	.	PROPN
easat-3738	132	8	,	,	PUNCT
easat-3738	132	9	principles	principle	NOUN
easat-3738	132	10	of	of	ADP
easat-3738	132	11	fracture	fracture	NOUN
easat-3738	132	12	remodeling	remodeling	NOUN
easat-3738	132	13	in	in	ADP
easat-3738	132	14	children	child	NOUN
easat-3738	132	15	.	.	PUNCT
easat-3738	133	1	injury	injury	NOUN
easat-3738	133	2	,	,	PUNCT
easat-3738	133	3	2005	2005	NUM
easat-3738	133	4	.	.	PUNCT
easat-3738	134	1	36(1	36(1	NUM
easat-3738	134	2	):	):	PUNCT
easat-3738	134	3	p.	p.	PROPN
easat-3738	134	4	s3	s3	PROPN
easat-3738	134	5	-	-	PUNCT
easat-3738	134	6	s11	s11	PROPN
easat-3738	134	7	.	.	PUNCT
easat-3738	135	1	[	[	X
easat-3738	135	2	6	6	NUM
easat-3738	135	3	]	]	SYM
easat-3738	135	4	baht	baht	NOUN
easat-3738	135	5	,	,	PUNCT
easat-3738	135	6	g.s	g.s	PROPN
easat-3738	135	7	.	.	PROPN
easat-3738	135	8	,	,	PUNCT
easat-3738	135	9	l.	l.	PROPN
easat-3738	135	10	vi	vi	PROPN
easat-3738	135	11	,	,	PUNCT
easat-3738	135	12	and	and	CCONJ
easat-3738	135	13	b.a	b.a	PROPN
easat-3738	135	14	.	.	PROPN
easat-3738	135	15	alman	alman	PROPN
easat-3738	135	16	,	,	PUNCT
easat-3738	135	17	the	the	DET
easat-3738	135	18	role	role	NOUN
easat-3738	135	19	of	of	ADP
easat-3738	135	20	the	the	DET
easat-3738	135	21	immune	immune	ADJ
easat-3738	135	22	cells	cell	NOUN
easat-3738	135	23	in	in	ADP
easat-3738	135	24	fracture	fracture	NOUN
easat-3738	135	25	healing	healing	NOUN
easat-3738	135	26	.	.	PUNCT
easat-3738	136	1	current	current	ADJ
easat-3738	136	2	osteoporosis	osteoporosis	NOUN
easat-3738	136	3	reports	report	NOUN
easat-3738	136	4	,	,	PUNCT
easat-3738	136	5	2018	2018	NUM
easat-3738	136	6	.	.	PUNCT
easat-3738	137	1	16	16	NUM
easat-3738	137	2	:	:	PUNCT
easat-3738	137	3	p.	p.	NOUN
easat-3738	137	4	138	138	NUM
easat-3738	137	5	-	-	SYM
easat-3738	137	6	145	145	NUM
easat-3738	137	7	.	.	PUNCT
easat-3738	138	1	[	[	X
easat-3738	138	2	7	7	X
easat-3738	138	3	]	]	X
easat-3738	138	4	schmidt	schmidt	ADJ
easat-3738	138	5	-	-	PUNCT
easat-3738	138	6	bleek	bleek	NOUN
easat-3738	138	7	,	,	PUNCT
easat-3738	138	8	k.	k.	PROPN
easat-3738	138	9	,	,	PUNCT
easat-3738	138	10	et	et	PROPN
easat-3738	138	11	al	al	PROPN
easat-3738	138	12	.	.	PROPN
easat-3738	138	13	,	,	PUNCT
easat-3738	138	14	inflammatory	inflammatory	ADJ
easat-3738	138	15	phase	phase	NOUN
easat-3738	138	16	of	of	ADP
easat-3738	138	17	bone	bone	NOUN
easat-3738	138	18	healing	healing	NOUN
easat-3738	138	19	initiates	initiate	VERB
easat-3738	138	20	the	the	DET
easat-3738	138	21	regenerative	regenerative	ADJ
easat-3738	138	22	healing	healing	NOUN
easat-3738	138	23	cascade	cascade	NOUN
easat-3738	138	24	.	.	PUNCT
easat-3738	139	1	cell	cell	NOUN
easat-3738	139	2	and	and	CCONJ
easat-3738	139	3	tissue	tissue	NOUN
easat-3738	139	4	research	research	NOUN
easat-3738	139	5	,	,	PUNCT
easat-3738	139	6	2012	2012	NUM
easat-3738	139	7	.	.	PUNCT
easat-3738	140	1	347	347	NUM
easat-3738	140	2	:	:	PUNCT
easat-3738	141	1	p.	p.	NOUN
easat-3738	141	2	567	567	NUM
easat-3738	141	3	-	-	SYM
easat-3738	141	4	573	573	NUM
easat-3738	141	5	.	.	PUNCT
easat-3738	142	1	[	[	X
easat-3738	142	2	8	8	NUM
easat-3738	142	3	]	]	X
easat-3738	142	4	lienau	lienau	PROPN
easat-3738	142	5	,	,	PUNCT
easat-3738	142	6	j.	j.	PROPN
easat-3738	142	7	,	,	PUNCT
easat-3738	142	8	et	et	PROPN
easat-3738	142	9	al	al	PROPN
easat-3738	142	10	.	.	PROPN
easat-3738	142	11	,	,	PUNCT
easat-3738	142	12	differential	differential	ADJ
easat-3738	142	13	regulation	regulation	NOUN
easat-3738	142	14	of	of	ADP
easat-3738	142	15	blood	blood	NOUN
easat-3738	142	16	vessel	vessel	NOUN
easat-3738	142	17	formation	formation	NOUN
easat-3738	142	18	between	between	ADP
easat-3738	142	19	standard	standard	ADJ
easat-3738	142	20	and	and	CCONJ
easat-3738	142	21	delayed	delay	VERB
easat-3738	142	22	bone	bone	NOUN
easat-3738	142	23	healing	healing	NOUN
easat-3738	142	24	.	.	PUNCT
easat-3738	143	1	journal	journal	NOUN
easat-3738	143	2	of	of	ADP
easat-3738	143	3	orthopaedic	orthopaedic	ADJ
easat-3738	143	4	research	research	NOUN
easat-3738	143	5	,	,	PUNCT
easat-3738	143	6	2009	2009	NUM
easat-3738	143	7	.	.	PUNCT
easat-3738	144	1	27(9	27(9	NUM
easat-3738	144	2	):	):	PUNCT
easat-3738	144	3	p.	p.	NOUN
easat-3738	144	4	1133	1133	NUM
easat-3738	144	5	-	-	SYM
easat-3738	144	6	1140	1140	NUM
easat-3738	144	7	.	.	PUNCT
easat-3738	145	1	[	[	X
easat-3738	145	2	9	9	NUM
easat-3738	145	3	]	]	X
easat-3738	145	4	schindeler	schindeler	NOUN
easat-3738	145	5	,	,	PUNCT
easat-3738	145	6	a.	a.	PROPN
easat-3738	145	7	,	,	PUNCT
easat-3738	145	8	et	et	PROPN
easat-3738	145	9	al	al	PROPN
easat-3738	145	10	.	.	PUNCT
easat-3738	145	11	bone	bone	NOUN
easat-3738	145	12	remodeling	remodeling	NOUN
easat-3738	145	13	during	during	ADP
easat-3738	145	14	fracture	fracture	PROPN
easat-3738	145	15	repair	repair	NOUN
easat-3738	145	16	:	:	PUNCT
easat-3738	145	17	the	the	DET
easat-3738	145	18	cellular	cellular	ADJ
easat-3738	145	19	picture	picture	NOUN
easat-3738	145	20	.	.	PUNCT
easat-3738	146	1	in	in	ADP
easat-3738	146	2	seminars	seminar	NOUN
easat-3738	146	3	in	in	ADP
easat-3738	146	4	cell	cell	NOUN
easat-3738	146	5	&	&	CCONJ
easat-3738	146	6	developmental	developmental	ADJ
easat-3738	146	7	biology	biology	NOUN
easat-3738	146	8	.	.	PUNCT
easat-3738	146	9	2008	2008	NUM
easat-3738	146	10	.	.	PUNCT
easat-3738	147	1	elsevier	elsevier	NOUN
easat-3738	147	2	.	.	PUNCT
easat-3738	148	1	[	[	X
easat-3738	148	2	10	10	NUM
easat-3738	148	3	]	]	X
easat-3738	148	4	elhawary	elhawary	ADJ
easat-3738	148	5	,	,	PUNCT
easat-3738	148	6	h.	h.	PROPN
easat-3738	148	7	,	,	PUNCT
easat-3738	148	8	et	et	PROPN
easat-3738	148	9	al	al	PROPN
easat-3738	148	10	.	.	PUNCT
easat-3738	148	11	bone	bone	NOUN
easat-3738	148	12	healing	healing	NOUN
easat-3738	148	13	and	and	CCONJ
easat-3738	148	14	inflammation	inflammation	NOUN
easat-3738	148	15	:	:	PUNCT
easat-3738	148	16	principles	principle	NOUN
easat-3738	148	17	of	of	ADP
easat-3738	148	18	fracture	fracture	NOUN
easat-3738	148	19	and	and	CCONJ
easat-3738	148	20	repair	repair	NOUN
easat-3738	148	21	.	.	PUNCT
easat-3738	149	1	in	in	ADP
easat-3738	149	2	seminars	seminar	NOUN
easat-3738	149	3	in	in	ADP
easat-3738	149	4	plastic	plastic	ADJ
easat-3738	149	5	surgery	surgery	NOUN
easat-3738	149	6	.	.	PUNCT
easat-3738	150	1	2021	2021	NUM
easat-3738	150	2	.	.	PUNCT
easat-3738	151	1	thieme	thieme	NOUN
easat-3738	151	2	medical	medical	ADJ
easat-3738	151	3	publishers	publisher	NOUN
easat-3738	151	4	,	,	PUNCT
easat-3738	151	5	inc	inc	PROPN
easat-3738	151	6	.	.	PUNCT
easat-3738	152	1	[	[	X
easat-3738	152	2	11	11	NUM
easat-3738	152	3	]	]	X
easat-3738	152	4	greenbaum	greenbaum	PROPN
easat-3738	152	5	,	,	PUNCT
easat-3738	152	6	m.	m.	NOUN
easat-3738	152	7	and	and	CCONJ
easat-3738	152	8	i.	i.	PROPN
easat-3738	152	9	kanat	kanat	PROPN
easat-3738	152	10	,	,	PUNCT
easat-3738	152	11	current	current	ADJ
easat-3738	152	12	concepts	concept	NOUN
easat-3738	152	13	in	in	ADP
easat-3738	152	14	bone	bone	NOUN
easat-3738	152	15	healing	healing	NOUN
easat-3738	152	16	.	.	PUNCT
easat-3738	153	1	review	review	NOUN
easat-3738	153	2	of	of	ADP
easat-3738	153	3	the	the	DET
easat-3738	153	4	literature	literature	NOUN
easat-3738	153	5	.	.	PUNCT
easat-3738	154	1	journal	journal	PROPN
easat-3738	154	2	of	of	ADP
easat-3738	154	3	the	the	DET
easat-3738	154	4	american	american	ADJ
easat-3738	154	5	podiatric	podiatric	PROPN
easat-3738	154	6	medical	medical	PROPN
easat-3738	154	7	association	association	PROPN
easat-3738	154	8	,	,	PUNCT
easat-3738	154	9	1993	1993	NUM
easat-3738	154	10	.	.	PUNCT
easat-3738	155	1	83(3	83(3	VERB
easat-3738	155	2	):	):	PUNCT
easat-3738	155	3	p.	p.	NOUN
easat-3738	155	4	123	123	NUM
easat-3738	155	5	-	-	SYM
easat-3738	155	6	129	129	NUM
easat-3738	155	7	.	.	PUNCT
easat-3738	156	1	[	[	X
easat-3738	156	2	12	12	NUM
easat-3738	156	3	]	]	X
easat-3738	156	4	einhorn	einhorn	PROPN
easat-3738	156	5	,	,	PUNCT
easat-3738	156	6	t.a	t.a	PROPN
easat-3738	156	7	.	.	PROPN
easat-3738	156	8	,	,	PUNCT
easat-3738	156	9	the	the	DET
easat-3738	156	10	cell	cell	NOUN
easat-3738	156	11	and	and	CCONJ
easat-3738	156	12	molecular	molecular	ADJ
easat-3738	156	13	biology	biology	NOUN
easat-3738	156	14	of	of	ADP
easat-3738	156	15	fracture	fracture	NOUN
easat-3738	156	16	healing	healing	NOUN
easat-3738	156	17	.	.	PUNCT
easat-3738	157	1	clinical	clinical	ADJ
easat-3738	157	2	orthopaedics	orthopaedic	NOUN
easat-3738	157	3	and	and	CCONJ
easat-3738	157	4	related	related	ADJ
easat-3738	157	5	research	research	NOUN
easat-3738	157	6	®	®	NOUN
easat-3738	157	7	,	,	PUNCT
easat-3738	157	8	1998	1998	NUM
easat-3738	157	9	.	.	PUNCT
easat-3738	158	1	355	355	NUM
easat-3738	158	2	:	:	PUNCT
easat-3738	158	3	p.	p.	NOUN
easat-3738	158	4	s7	s7	NOUN
easat-3738	158	5	-	-	PUNCT
easat-3738	158	6	s21	s21	NOUN
easat-3738	158	7	.	.	PUNCT
easat-3738	159	1	[	[	X
easat-3738	159	2	13	13	NUM
easat-3738	159	3	]	]	PUNCT
easat-3738	159	4	gerstenfeld	gerstenfeld	PROPN
easat-3738	159	5	,	,	PUNCT
easat-3738	159	6	l.c	l.c	PROPN
easat-3738	159	7	.	.	PROPN
easat-3738	159	8	,	,	PUNCT
easat-3738	159	9	et	et	PROPN
easat-3738	159	10	al	al	PROPN
easat-3738	159	11	.	.	PROPN
easat-3738	159	12	,	,	PUNCT
easat-3738	159	13	three	three	NUM
easat-3738	159	14	-	-	PUNCT
easat-3738	159	15	dimensional	dimensional	ADJ
easat-3738	159	16	reconstruction	reconstruction	NOUN
easat-3738	159	17	of	of	ADP
easat-3738	159	18	fracture	fracture	ADJ
easat-3738	159	19	callus	callus	ADJ
easat-3738	159	20	morphogenesis	morphogenesis	NOUN
easat-3738	159	21	.	.	PUNCT
easat-3738	160	1	journal	journal	PROPN
easat-3738	160	2	of	of	ADP
easat-3738	160	3	histochemistry	histochemistry	PROPN
easat-3738	160	4	&	&	CCONJ
easat-3738	160	5	cytochemistry	cytochemistry	PROPN
easat-3738	160	6	,	,	PUNCT
easat-3738	160	7	2006	2006	NUM
easat-3738	160	8	.	.	PUNCT
easat-3738	161	1	54(11	54(11	NUM
easat-3738	161	2	):	):	PUNCT
easat-3738	161	3	p.	p.	NOUN
easat-3738	161	4	1215	1215	NUM
easat-3738	161	5	-	-	SYM
easat-3738	161	6	1228	1228	NUM
easat-3738	161	7	.	.	PUNCT
easat-3738	162	1	[	[	X
easat-3738	162	2	14	14	NUM
easat-3738	162	3	]	]	X
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easat-3738	162	5	,	,	PUNCT
easat-3738	162	6	e.	e.	PROPN
easat-3738	162	7	,	,	PUNCT
easat-3738	162	8	j.d	j.d	PROPN
easat-3738	162	9	.	.	PROPN
easat-3738	162	10	lubahn	lubahn	PROPN
easat-3738	162	11	,	,	PUNCT
easat-3738	162	12	and	and	CCONJ
easat-3738	162	13	j.	j.	PROPN
easat-3738	162	14	evans	evans	PROPN
easat-3738	162	15	,	,	PUNCT
easat-3738	162	16	risk	risk	NOUN
easat-3738	162	17	factors	factor	NOUN
easat-3738	162	18	,	,	PUNCT
easat-3738	162	19	treatment	treatment	NOUN
easat-3738	162	20	,	,	PUNCT
easat-3738	162	21	and	and	CCONJ
easat-3738	162	22	outcomes	outcome	NOUN
easat-3738	162	23	associated	associate	VERB
easat-3738	162	24	with	with	ADP
easat-3738	162	25	nonunion	nonunion	NOUN
easat-3738	162	26	of	of	ADP
easat-3738	162	27	the	the	DET
easat-3738	162	28	midshaft	midshaft	PROPN
easat-3738	162	29	humerus	humerus	PROPN
easat-3738	162	30	fracture	fracture	PROPN
easat-3738	162	31	.	.	PUNCT
easat-3738	163	1	journal	journal	NOUN
easat-3738	163	2	of	of	ADP
easat-3738	163	3	surgical	surgical	ADJ
easat-3738	163	4	orthopaedic	orthopaedic	ADJ
easat-3738	163	5	advances	advance	NOUN
easat-3738	163	6	,	,	PUNCT
easat-3738	163	7	2005	2005	NUM
easat-3738	163	8	.	.	PUNCT
easat-3738	164	1	14(2	14(2	NUM
easat-3738	164	2	):	):	PUNCT
easat-3738	164	3	p.	p.	NOUN
easat-3738	164	4	64	64	NUM
easat-3738	164	5	-	-	SYM
easat-3738	164	6	72	72	NUM
easat-3738	164	7	.	.	PUNCT
easat-3738	165	1	[	[	X
easat-3738	165	2	15	15	NUM
easat-3738	165	3	]	]	X
easat-3738	165	4	pape	pape	NOUN
easat-3738	165	5	,	,	PUNCT
easat-3738	165	6	h.-c	h.-c	PROPN
easat-3738	165	7	.	.	PUNCT
easat-3738	165	8	,	,	PUNCT
easat-3738	165	9	et	et	PROPN
easat-3738	165	10	al	al	PROPN
easat-3738	165	11	.	.	PROPN
easat-3738	165	12	,	,	PUNCT
easat-3738	165	13	effects	effect	NOUN
easat-3738	165	14	of	of	ADP
easat-3738	165	15	intramedullary	intramedullary	ADJ
easat-3738	165	16	femoral	femoral	ADJ
easat-3738	165	17	fracture	fracture	NOUN
easat-3738	165	18	fixation	fixation	NOUN
easat-3738	165	19	:	:	PUNCT
easat-3738	165	20	what	what	PRON
easat-3738	165	21	is	be	AUX
easat-3738	165	22	the	the	DET
easat-3738	165	23	impact	impact	NOUN
easat-3738	165	24	of	of	ADP
easat-3738	165	25	experimental	experimental	ADJ
easat-3738	165	26	studies	study	NOUN
easat-3738	165	27	in	in	ADP
easat-3738	165	28	regards	regard	NOUN
easat-3738	165	29	to	to	ADP
easat-3738	165	30	the	the	DET
easat-3738	165	31	clinical	clinical	ADJ
easat-3738	165	32	knowledge	knowledge	NOUN
easat-3738	165	33	?	?	PUNCT
easat-3738	166	1	shock	shock	NOUN
easat-3738	166	2	,	,	PUNCT
easat-3738	166	3	2002	2002	NUM
easat-3738	166	4	.	.	PUNCT
easat-3738	167	1	18(4	18(4	NUM
easat-3738	167	2	):	):	PUNCT
easat-3738	168	1	p.	p.	NOUN
easat-3738	168	2	291	291	NUM
easat-3738	168	3	-	-	SYM
easat-3738	168	4	300	300	NUM
easat-3738	168	5	.	.	PUNCT
easat-3738	169	1	https://creativecommons.org/licenses/by/4.0/	https://creativecommons.org/licenses/by/4.0/	PROPN
easat-3738	169	2	2541	2541	PROPN
easat-3738	169	3	edelweiss	edelweiss	PROPN
easat-3738	169	4	applied	apply	VERB
easat-3738	169	5	science	science	NOUN
easat-3738	169	6	and	and	CCONJ
easat-3738	169	7	technology	technology	NOUN
easat-3738	169	8	issn	issn	PROPN
easat-3738	169	9	:	:	PUNCT
easat-3738	169	10	2576	2576	NUM
easat-3738	169	11	-	-	SYM
easat-3738	169	12	8484	8484	NUM
easat-3738	169	13	vol	vol	NOUN
easat-3738	169	14	.	.	PROPN
easat-3738	169	15	8	8	NUM
easat-3738	169	16	,	,	PUNCT
easat-3738	169	17	no	no	INTJ
easat-3738	169	18	.	.	NOUN
easat-3738	169	19	5	5	NUM
easat-3738	169	20	:	:	SYM
easat-3738	169	21	2536	2536	NUM
easat-3738	169	22	-	-	SYM
easat-3738	169	23	2541	2541	NUM
easat-3738	169	24	,	,	PUNCT
easat-3738	169	25	2024	2024	NUM
easat-3738	169	26	doi	doi	NOUN
easat-3738	169	27	:	:	PUNCT
easat-3738	169	28	10.55214/25768484.v8i6.3738	10.55214/25768484.v8i6.3738	NUM
easat-3738	169	29	©	©	NOUN
easat-3738	169	30	2024	2024	NUM
easat-3738	169	31	by	by	ADP
easat-3738	169	32	the	the	DET
easat-3738	169	33	authors	author	NOUN
easat-3738	169	34	;	;	PUNCT
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easat-3738	169	37	gate	gate	NOUN
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easat-3738	170	2	16	16	NUM
easat-3738	170	3	]	]	X
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easat-3738	170	5	,	,	PUNCT
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easat-3738	170	8	,	,	PUNCT
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easat-3738	170	12	internal	internal	ADJ
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easat-3738	170	14	of	of	ADP
easat-3738	170	15	long	long	ADJ
easat-3738	170	16	bone	bone	NOUN
easat-3738	170	17	fractures	fracture	NOUN
easat-3738	170	18	:	:	PUNCT
easat-3738	170	19	the	the	DET
easat-3738	170	20	scientific	scientific	ADJ
easat-3738	170	21	basis	basis	NOUN
easat-3738	170	22	of	of	ADP
easat-3738	170	23	biological	biological	ADJ
easat-3738	170	24	internal	internal	ADJ
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easat-3738	170	26	:	:	PUNCT
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easat-3738	170	28	a	a	DET
easat-3738	170	29	new	new	ADJ
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easat-3738	170	31	between	between	ADP
easat-3738	170	32	stability	stability	NOUN
easat-3738	170	33	and	and	CCONJ
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easat-3738	170	35	.	.	PUNCT
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easat-3738	171	10	,	,	PUNCT
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easat-3738	172	2	):	):	PUNCT
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easat-3738	172	5	.	.	PUNCT
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easat-3738	173	2	17	17	NUM
easat-3738	173	3	]	]	X
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easat-3738	173	5	,	,	PUNCT
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easat-3738	174	2	,	,	PUNCT
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easat-3738	175	2	):	):	PUNCT
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easat-3738	175	5	-	-	SYM
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easat-3738	175	7	.	.	PUNCT
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easat-3738	176	3	]	]	PUNCT
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easat-3738	176	5	,	,	PUNCT
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easat-3738	176	18	healing	healing	NOUN
easat-3738	176	19	overview	overview	NOUN
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easat-3738	176	23	[	[	X
easat-3738	176	24	internet	internet	NOUN
easat-3738	176	25	]	]	PUNCT
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easat-3738	177	2	,	,	PUNCT
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easat-3738	177	5	.	.	PUNCT
easat-3738	178	1	[	[	X
easat-3738	178	2	19	19	NUM
easat-3738	178	3	]	]	PUNCT
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easat-3738	178	5	from	from	ADP
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easat-3738	179	2	20	20	NUM
easat-3738	179	3	]	]	X
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easat-3738	179	25	bone	bone	NOUN
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easat-3738	180	7	.	.	PUNCT
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easat-3738	181	2	):	):	PUNCT
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easat-3738	182	3	-	-	SYM
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easat-3738	182	5	.	.	PUNCT
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easat-3738	183	2	21	21	NUM
easat-3738	183	3	]	]	X
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easat-3738	183	5	,	,	PUNCT
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easat-3738	183	8	,	,	PUNCT
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easat-3738	183	21	.	.	PUNCT
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easat-3738	184	6	:	:	PUNCT
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easat-3738	184	9	-	-	SYM
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easat-3738	184	11	.	.	PUNCT
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easat-3738	185	3	]	]	X
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easat-3738	185	5	-	-	PUNCT
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easat-3738	185	24	.	.	PUNCT
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easat-3738	186	5	.	.	PUNCT
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easat-3738	187	2	):	):	PUNCT
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easat-3738	187	5	-	-	SYM
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easat-3738	187	7	.	.	PUNCT
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easat-3738	188	3	]	]	SYM
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easat-3738	189	7	.	.	PUNCT
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easat-3738	190	2	):	):	PUNCT
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easat-3738	190	5	-	-	SYM
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easat-3738	191	3	]	]	PUNCT
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easat-3738	191	5	,	,	PUNCT
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easat-3738	191	16	:	:	PUNCT
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easat-3738	192	2	.	.	PUNCT
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easat-3738	195	2	:	:	PUNCT
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easat-3738	199	2	):	):	PUNCT
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easat-3738	199	5	-	-	SYM
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easat-3738	199	7	.	.	PUNCT
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easat-3738	200	20	.	.	PUNCT
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easat-3738	201	6	.	.	PUNCT
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easat-3738	202	2	):	):	PUNCT
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easat-3738	203	3	-	-	SYM
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easat-3738	203	5	.	.	PUNCT
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easat-3738	205	6	.	.	PUNCT
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easat-3738	206	2	):	):	PUNCT
easat-3738	206	3	p.	p.	NOUN
easat-3738	206	4	685	685	NUM
easat-3738	206	5	-	-	SYM
easat-3738	206	6	697	697	NUM
easat-3738	206	7	.	.	PUNCT
easat-3738	207	1	[	[	X
easat-3738	207	2	29	29	NUM
easat-3738	207	3	]	]	X
easat-3738	207	4	chen	chen	PROPN
easat-3738	207	5	,	,	PUNCT
easat-3738	207	6	y.	y.	PROPN
easat-3738	207	7	,	,	PUNCT
easat-3738	207	8	et	et	PROPN
easat-3738	207	9	al	al	PROPN
easat-3738	207	10	.	.	PROPN
easat-3738	207	11	,	,	PUNCT
easat-3738	207	12	challenges	challenge	NOUN
easat-3738	207	13	to	to	PART
easat-3738	207	14	improve	improve	VERB
easat-3738	207	15	bone	bone	NOUN
easat-3738	207	16	healing	healing	NOUN
easat-3738	207	17	under	under	ADP
easat-3738	207	18	diabetic	diabetic	ADJ
easat-3738	207	19	conditions	condition	NOUN
easat-3738	207	20	.	.	PUNCT
easat-3738	208	1	frontiers	frontier	NOUN
easat-3738	208	2	in	in	ADP
easat-3738	208	3	endocrinology	endocrinology	NOUN
easat-3738	208	4	,	,	PUNCT
easat-3738	208	5	2022	2022	NUM
easat-3738	208	6	.	.	PUNCT
easat-3738	209	1	13	13	NUM
easat-3738	209	2	:	:	PUNCT
easat-3738	209	3	p.	p.	NOUN
easat-3738	209	4	861878	861878	NUM
easat-3738	209	5	.	.	PUNCT
easat-3738	210	1	[	[	X
easat-3738	210	2	30	30	NUM
easat-3738	210	3	]	]	X
easat-3738	210	4	santana	santana	PROPN
easat-3738	210	5	,	,	PUNCT
easat-3738	210	6	r.b	r.b	PROPN
easat-3738	210	7	.	.	PROPN
easat-3738	210	8	,	,	PUNCT
easat-3738	210	9	et	et	PROPN
easat-3738	210	10	al	al	PROPN
easat-3738	210	11	.	.	PROPN
easat-3738	210	12	,	,	PUNCT
easat-3738	210	13	a	a	DET
easat-3738	210	14	role	role	NOUN
easat-3738	210	15	for	for	ADP
easat-3738	210	16	advanced	advanced	ADJ
easat-3738	210	17	glycation	glycation	NOUN
easat-3738	210	18	end	end	NOUN
easat-3738	210	19	products	product	NOUN
easat-3738	210	20	in	in	ADP
easat-3738	210	21	diminished	diminish	VERB
easat-3738	210	22	bone	bone	NOUN
easat-3738	210	23	healing	healing	NOUN
easat-3738	210	24	in	in	ADP
easat-3738	210	25	type	type	NOUN
easat-3738	210	26	1	1	NUM
easat-3738	210	27	diabetes	diabetes	NOUN
easat-3738	210	28	.	.	PUNCT
easat-3738	211	1	diabetes	diabetes	NOUN
easat-3738	211	2	,	,	PUNCT
easat-3738	211	3	2003	2003	NUM
easat-3738	211	4	.	.	PUNCT
easat-3738	212	1	52(6	52(6	NUM
easat-3738	212	2	):	):	PUNCT
easat-3738	212	3	p.	p.	NOUN
easat-3738	212	4	1502	1502	NUM
easat-3738	212	5	-	-	SYM
easat-3738	212	6	1510	1510	NUM
easat-3738	212	7	.	.	PUNCT
easat-3738	213	1	[	[	X
easat-3738	213	2	31	31	NUM
easat-3738	213	3	]	]	X
easat-3738	213	4	furst	furst	PROPN
easat-3738	213	5	,	,	PUNCT
easat-3738	213	6	j.r	j.r	PROPN
easat-3738	213	7	.	.	PROPN
easat-3738	213	8	,	,	PUNCT
easat-3738	213	9	et	et	PROPN
easat-3738	213	10	al	al	PROPN
easat-3738	213	11	.	.	PROPN
easat-3738	213	12	,	,	PUNCT
easat-3738	213	13	advanced	advanced	ADJ
easat-3738	213	14	glycation	glycation	NOUN
easat-3738	213	15	endproducts	endproduct	NOUN
easat-3738	213	16	and	and	CCONJ
easat-3738	213	17	bone	bone	NOUN
easat-3738	213	18	material	material	NOUN
easat-3738	213	19	strength	strength	NOUN
easat-3738	213	20	in	in	ADP
easat-3738	213	21	type	type	NOUN
easat-3738	213	22	2	2	NUM
easat-3738	213	23	diabetes	diabetes	NOUN
easat-3738	213	24	.	.	PUNCT
easat-3738	214	1	the	the	DET
easat-3738	214	2	journal	journal	NOUN
easat-3738	214	3	of	of	ADP
easat-3738	214	4	clinical	clinical	ADJ
easat-3738	214	5	endocrinology	endocrinology	NOUN
easat-3738	214	6	&	&	CCONJ
easat-3738	214	7	metabolism	metabolism	NOUN
easat-3738	214	8	,	,	PUNCT
easat-3738	214	9	2016	2016	NUM
easat-3738	214	10	.	.	PUNCT
easat-3738	214	11	101(6	101(6	NUM
easat-3738	214	12	):	):	PUNCT
easat-3738	214	13	p.	p.	NOUN
easat-3738	214	14	2502	2502	NUM
easat-3738	214	15	-	-	SYM
easat-3738	214	16	2510	2510	NUM
easat-3738	214	17	.	.	PUNCT
easat-3738	215	1	[	[	X
easat-3738	215	2	32	32	NUM
easat-3738	215	3	]	]	X
easat-3738	215	4	chow	chow	PROPN
easat-3738	215	5	,	,	PUNCT
easat-3738	215	6	s.k.-h	s.k.-h	PROPN
easat-3738	215	7	.	.	PROPN
easat-3738	215	8	,	,	PUNCT
easat-3738	215	9	et	et	PROPN
easat-3738	215	10	al	al	PROPN
easat-3738	215	11	.	.	PROPN
easat-3738	215	12	,	,	PUNCT
easat-3738	215	13	the	the	DET
easat-3738	215	14	advantages	advantage	NOUN
easat-3738	215	15	and	and	CCONJ
easat-3738	215	16	shortcomings	shortcoming	NOUN
easat-3738	215	17	of	of	ADP
easat-3738	215	18	stem	stem	NOUN
easat-3738	215	19	cell	cell	NOUN
easat-3738	215	20	therapy	therapy	NOUN
easat-3738	215	21	for	for	ADP
easat-3738	215	22	enhanced	enhanced	ADJ
easat-3738	215	23	bone	bone	NOUN
easat-3738	215	24	healing	healing	NOUN
easat-3738	215	25	.	.	PUNCT
easat-3738	216	1	tissue	tissue	NOUN
easat-3738	216	2	engineering	engineering	NOUN
easat-3738	216	3	,	,	PUNCT
easat-3738	216	4	2024(ja	2024(ja	NUM
easat-3738	216	5	)	)	PUNCT
easat-3738	216	6	.	.	PUNCT
easat-3738	217	1	[	[	X
easat-3738	217	2	33	33	NUM
easat-3738	217	3	]	]	PUNCT
easat-3738	217	4	robles	roble	NOUN
easat-3738	217	5	,	,	PUNCT
easat-3738	217	6	n.	n.	NOUN
easat-3738	217	7	,	,	PUNCT
easat-3738	217	8	impact	impact	NOUN
easat-3738	217	9	of	of	ADP
easat-3738	217	10	e	e	NOUN
easat-3738	217	11	-	-	NOUN
easat-3738	217	12	cigarettes	cigarette	NOUN
easat-3738	217	13	on	on	ADP
easat-3738	217	14	oral	oral	ADJ
easat-3738	217	15	wound	wound	NOUN
easat-3738	217	16	healing	healing	NOUN
easat-3738	217	17	.	.	PUNCT
easat-3738	218	1	2023	2023	NUM
easat-3738	218	2	,	,	PUNCT
easat-3738	218	3	the	the	DET
easat-3738	218	4	ohio	ohio	PROPN
easat-3738	218	5	state	state	PROPN
easat-3738	218	6	university	university	PROPN
easat-3738	218	7	.	.	PUNCT
easat-3738	219	1	[	[	X
easat-3738	219	2	34	34	NUM
easat-3738	219	3	]	]	X
easat-3738	219	4	rinderknecht	rinderknecht	NOUN
easat-3738	219	5	,	,	PUNCT
easat-3738	219	6	h.s	h.s	PROPN
easat-3738	219	7	.	.	PROPN
easat-3738	219	8	,	,	PUNCT
easat-3738	219	9	establishment	establishment	NOUN
easat-3738	219	10	of	of	ADP
easat-3738	219	11	a	a	DET
easat-3738	219	12	3d	3d	NOUN
easat-3738	219	13	-	-	PUNCT
easat-3738	219	14	co	co	NOUN
easat-3738	219	15	-	-	NOUN
easat-3738	219	16	culture	culture	ADJ
easat-3738	219	17	approach	approach	NOUN
easat-3738	219	18	for	for	ADP
easat-3738	219	19	studying	study	VERB
easat-3738	219	20	early	early	ADJ
easat-3738	219	21	fracture	fracture	NOUN
easat-3738	219	22	healing	healing	NOUN
easat-3738	219	23	of	of	ADP
easat-3738	219	24	smokers	smoker	NOUN
easat-3738	219	25	in	in	ADP
easat-3738	219	26	vitro	vitro	X
easat-3738	219	27	.	.	PUNCT
easat-3738	220	1	2024	2024	NUM
easat-3738	220	2	.	.	PUNCT
easat-3738	221	1	[	[	X
easat-3738	221	2	35	35	NUM
easat-3738	221	3	]	]	SYM
easat-3738	221	4	ma	ma	PROPN
easat-3738	221	5	,	,	PUNCT
easat-3738	221	6	q.	q.	PROPN
easat-3738	221	7	,	,	PUNCT
easat-3738	221	8	et	et	PROPN
easat-3738	221	9	al	al	PROPN
easat-3738	221	10	.	.	PROPN
easat-3738	221	11	,	,	PUNCT
easat-3738	221	12	significance	significance	NOUN
easat-3738	221	13	of	of	ADP
easat-3738	221	14	mechanical	mechanical	ADJ
easat-3738	221	15	loading	loading	NOUN
easat-3738	221	16	in	in	ADP
easat-3738	221	17	bone	bone	NOUN
easat-3738	221	18	fracture	fracture	NOUN
easat-3738	221	19	healing	healing	NOUN
easat-3738	221	20	,	,	PUNCT
easat-3738	221	21	bone	bone	NOUN
easat-3738	221	22	regeneration	regeneration	NOUN
easat-3738	221	23	,	,	PUNCT
easat-3738	221	24	and	and	CCONJ
easat-3738	221	25	vascularization	vascularization	NOUN
easat-3738	221	26	.	.	PUNCT
easat-3738	222	1	journal	journal	NOUN
easat-3738	222	2	of	of	ADP
easat-3738	222	3	tissue	tissue	NOUN
easat-3738	222	4	engineering	engineering	NOUN
easat-3738	222	5	,	,	PUNCT
easat-3738	222	6	2023	2023	NUM
easat-3738	222	7	.	.	PUNCT
easat-3738	223	1	14	14	NUM
easat-3738	223	2	:	:	PUNCT
easat-3738	224	1	p.	p.	NOUN
easat-3738	224	2	20417314231172573	20417314231172573	NUM
easat-3738	224	3	.	.	PUNCT
easat-3738	225	1	[	[	X
easat-3738	225	2	36	36	NUM
easat-3738	225	3	]	]	X
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easat-3738	225	5	,	,	PUNCT
easat-3738	225	6	d.	d.	PROPN
easat-3738	225	7	,	,	PUNCT
easat-3738	225	8	et	et	PROPN
easat-3738	225	9	al	al	PROPN
easat-3738	225	10	.	.	PROPN
easat-3738	225	11	,	,	PUNCT
easat-3738	225	12	bone	bone	NOUN
easat-3738	225	13	healing	healing	NOUN
easat-3738	225	14	gone	go	VERB
easat-3738	225	15	wrong	wrong	ADJ
easat-3738	225	16	:	:	PUNCT
easat-3738	225	17	pathological	pathological	ADJ
easat-3738	225	18	fracture	fracture	NOUN
easat-3738	225	19	healing	healing	NOUN
easat-3738	225	20	and	and	CCONJ
easat-3738	225	21	non	non	NOUN
easat-3738	225	22	-	-	NOUN
easat-3738	225	23	unions	union	NOUN
easat-3738	225	24	—	—	PUNCT
easat-3738	225	25	overview	overview	NOUN
easat-3738	225	26	of	of	ADP
easat-3738	225	27	basic	basic	ADJ
easat-3738	225	28	and	and	CCONJ
easat-3738	225	29	clinical	clinical	ADJ
easat-3738	225	30	aspects	aspect	NOUN
easat-3738	225	31	and	and	CCONJ
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easat-3738	225	33	review	review	NOUN
easat-3738	225	34	of	of	ADP
easat-3738	225	35	risk	risk	NOUN
easat-3738	225	36	factors	factor	NOUN
easat-3738	225	37	.	.	PUNCT
easat-3738	226	1	bioengineering	bioengineering	NOUN
easat-3738	226	2	,	,	PUNCT
easat-3738	226	3	2023	2023	NUM
easat-3738	226	4	.	.	PUNCT
easat-3738	227	1	10(1	10(1	NUM
easat-3738	227	2	):	):	PUNCT
easat-3738	227	3	p.	p.	NOUN
easat-3738	227	4	85	85	NUM
easat-3738	227	5	.	.	PUNCT
easat-3738	228	1	[	[	X
easat-3738	228	2	37	37	NUM
easat-3738	228	3	]	]	X
easat-3738	228	4	barcik	barcik	PROPN
easat-3738	228	5	,	,	PUNCT
easat-3738	228	6	j.	j.	PROPN
easat-3738	228	7	,	,	PUNCT
easat-3738	228	8	et	et	PROPN
easat-3738	228	9	al	al	PROPN
easat-3738	228	10	.	.	PROPN
easat-3738	228	11	,	,	PUNCT
easat-3738	228	12	the	the	DET
easat-3738	228	13	absence	absence	NOUN
easat-3738	228	14	of	of	ADP
easat-3738	228	15	immediate	immediate	ADJ
easat-3738	228	16	stimulation	stimulation	NOUN
easat-3738	228	17	delays	delay	NOUN
easat-3738	228	18	bone	bone	NOUN
easat-3738	228	19	healing	healing	NOUN
easat-3738	228	20	.	.	PUNCT
easat-3738	229	1	bone	bone	NOUN
easat-3738	229	2	,	,	PUNCT
easat-3738	229	3	2023	2023	NUM
easat-3738	229	4	.	.	PUNCT
easat-3738	230	1	175	175	NUM
easat-3738	230	2	:	:	PUNCT
easat-3738	231	1	p.	p.	NOUN
easat-3738	231	2	116834	116834	NUM
easat-3738	231	3	.	.	PUNCT
easat-3738	232	1	[	[	X
easat-3738	232	2	38	38	NUM
easat-3738	232	3	]	]	PUNCT
easat-3738	232	4	borrelli	borrelli	PROPN
easat-3738	232	5	,	,	PUNCT
easat-3738	232	6	j.	j.	PROPN
easat-3738	232	7	and	and	CCONJ
easat-3738	232	8	b.l	b.l	PROPN
easat-3738	232	9	.	.	PROPN
easat-3738	232	10	norris	norris	PROPN
easat-3738	232	11	,	,	PUNCT
easat-3738	232	12	case	case	NOUN
easat-3738	232	13	studies	study	NOUN
easat-3738	232	14	in	in	ADP
easat-3738	232	15	fracture	fracture	NOUN
easat-3738	232	16	healing	healing	NOUN
easat-3738	232	17	and	and	CCONJ
easat-3738	232	18	nonunions	nonunion	NOUN
easat-3738	232	19	.	.	PUNCT
easat-3738	233	1	essential	essential	ADJ
easat-3738	233	2	biomechanics	biomechanic	NOUN
easat-3738	233	3	for	for	ADP
easat-3738	233	4	orthopedic	orthopedic	ADJ
easat-3738	233	5	trauma	trauma	NOUN
easat-3738	233	6	:	:	PUNCT
easat-3738	233	7	a	a	DET
easat-3738	233	8	case	case	NOUN
easat-3738	233	9	-	-	PUNCT
easat-3738	233	10	based	base	VERB
easat-3738	233	11	guide	guide	NOUN
easat-3738	233	12	,	,	PUNCT
easat-3738	233	13	2020	2020	NUM
easat-3738	233	14	:	:	PUNCT
easat-3738	233	15	p.	p.	NOUN
easat-3738	233	16	27	27	NUM
easat-3738	233	17	-	-	SYM
easat-3738	233	18	42	42	NUM
easat-3738	233	19	.	.	PUNCT
easat-3738	234	1	[	[	X
easat-3738	234	2	39	39	NUM
easat-3738	234	3	]	]	X
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easat-3738	234	5	,	,	PUNCT
easat-3738	234	6	d.j	d.j	PROPN
easat-3738	234	7	.	.	PROPN
easat-3738	234	8	,	,	PUNCT
easat-3738	234	9	et	et	PROPN
easat-3738	234	10	al	al	PROPN
easat-3738	234	11	.	.	PROPN
easat-3738	234	12	,	,	PUNCT
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easat-3738	234	14	into	into	ADP
easat-3738	234	15	the	the	DET
easat-3738	234	16	cellular	cellular	ADJ
easat-3738	234	17	and	and	CCONJ
easat-3738	234	18	molecular	molecular	ADJ
easat-3738	234	19	mechanisms	mechanism	NOUN
easat-3738	234	20	that	that	PRON
easat-3738	234	21	govern	govern	VERB
easat-3738	234	22	the	the	DET
easat-3738	234	23	fracture	fracture	NOUN
easat-3738	234	24	-	-	PUNCT
easat-3738	234	25	healing	healing	NOUN
easat-3738	234	26	process	process	NOUN
easat-3738	234	27	:	:	PUNCT
easat-3738	234	28	a	a	DET
easat-3738	234	29	narrative	narrative	NOUN
easat-3738	234	30	review	review	NOUN
easat-3738	234	31	.	.	PUNCT
easat-3738	235	1	journal	journal	NOUN
easat-3738	235	2	of	of	ADP
easat-3738	235	3	clinical	clinical	ADJ
easat-3738	235	4	medicine	medicine	NOUN
easat-3738	235	5	,	,	PUNCT
easat-3738	235	6	2021	2021	NUM
easat-3738	235	7	.	.	PUNCT
easat-3738	236	1	10(16	10(16	NUM
easat-3738	236	2	):	):	PUNCT
easat-3738	236	3	p.	p.	NOUN
easat-3738	236	4	3554	3554	NUM
easat-3738	236	5	.	.	PUNCT
easat-3738	237	1	[	[	X
easat-3738	237	2	40	40	NUM
easat-3738	237	3	]	]	X
easat-3738	237	4	zhao	zhao	PROPN
easat-3738	237	5	,	,	PUNCT
easat-3738	237	6	c.	c.	PROPN
easat-3738	237	7	,	,	PUNCT
easat-3738	237	8	et	et	PROPN
easat-3738	237	9	al	al	PROPN
easat-3738	237	10	.	.	PROPN
easat-3738	237	11	,	,	PUNCT
easat-3738	237	12	macrophages	macrophage	NOUN
easat-3738	237	13	in	in	ADP
easat-3738	237	14	tissue	tissue	NOUN
easat-3738	237	15	repair	repair	NOUN
easat-3738	237	16	and	and	CCONJ
easat-3738	237	17	regeneration	regeneration	NOUN
easat-3738	237	18	:	:	PUNCT
easat-3738	237	19	insights	insight	NOUN
easat-3738	237	20	from	from	ADP
easat-3738	237	21	zebrafish	zebrafish	ADJ
easat-3738	237	22	.	.	PUNCT
easat-3738	238	1	cell	cell	NOUN
easat-3738	238	2	regeneration	regeneration	NOUN
easat-3738	238	3	,	,	PUNCT
easat-3738	238	4	2024	2024	NUM
easat-3738	238	5	.	.	PUNCT
easat-3738	239	1	13(1	13(1	NUM
easat-3738	239	2	):	):	PUNCT
easat-3738	240	1	p.	p.	NOUN
easat-3738	240	2	12	12	NUM
easat-3738	240	3	.	.	PUNCT
easat-3738	241	1	[	[	X
easat-3738	241	2	41	41	NUM
easat-3738	241	3	]	]	PUNCT
easat-3738	241	4	immune	immune	ADJ
easat-3738	241	5	system	system	NOUN
easat-3738	241	6	can	can	AUX
easat-3738	241	7	delay	delay	VERB
easat-3738	241	8	healing	healing	NOUN
easat-3738	241	9	of	of	ADP
easat-3738	241	10	bone	bone	NOUN
easat-3738	241	11	fractures	fracture	NOUN
easat-3738	241	12	.	.	PUNCT
easat-3738	241	13	2013	2013	NUM
easat-3738	241	14	;	;	PUNCT
easat-3738	241	15	available	available	ADJ
easat-3738	241	16	from	from	ADP
easat-3738	241	17	:	:	PUNCT
easat-3738	241	18	https://www.sciencedaily.com/releases/2013/03/130321092945.htm	https://www.sciencedaily.com/releases/2013/03/130321092945.htm	NOUN
easat-3738	241	19	.	.	PUNCT
easat-3738	242	1	[	[	X
easat-3738	242	2	42	42	NUM
easat-3738	242	3	]	]	X
easat-3738	242	4	richardson	richardson	PROPN
easat-3738	242	5	,	,	PUNCT
easat-3738	242	6	j.	j.	PROPN
easat-3738	242	7	,	,	PUNCT
easat-3738	242	8	et	et	PROPN
easat-3738	242	9	al	al	PROPN
easat-3738	242	10	.	.	PROPN
easat-3738	242	11	,	,	PUNCT
easat-3738	242	12	fracture	fracture	NOUN
easat-3738	242	13	healing	healing	NOUN
easat-3738	242	14	in	in	ADP
easat-3738	242	15	hiv	hiv	PROPN
easat-3738	242	16	-	-	PUNCT
easat-3738	242	17	positive	positive	ADJ
easat-3738	242	18	populations	population	NOUN
easat-3738	242	19	.	.	PUNCT
easat-3738	243	1	the	the	DET
easat-3738	243	2	journal	journal	NOUN
easat-3738	243	3	of	of	ADP
easat-3738	243	4	bone	bone	NOUN
easat-3738	243	5	&	&	CCONJ
easat-3738	243	6	joint	joint	ADJ
easat-3738	243	7	surgery	surgery	NOUN
easat-3738	243	8	british	british	ADJ
easat-3738	243	9	volume	volume	NOUN
easat-3738	243	10	,	,	PUNCT
easat-3738	243	11	2008	2008	NUM
easat-3738	243	12	.	.	PUNCT
easat-3738	244	1	90(8	90(8	NUM
easat-3738	244	2	):	):	PUNCT
easat-3738	245	1	p.	p.	NOUN
easat-3738	245	2	988	988	NUM
easat-3738	245	3	-	-	SYM
easat-3738	245	4	994	994	NUM
easat-3738	245	5	.	.	PUNCT
easat-3738	246	1	[	[	X
easat-3738	246	2	43	43	NUM
easat-3738	246	3	]	]	X
easat-3738	246	4	al‐sebaei	al‐sebaei	PROPN
easat-3738	246	5	,	,	PUNCT
easat-3738	246	6	m.o	m.o	PROPN
easat-3738	246	7	.	.	PROPN
easat-3738	246	8	,	,	PUNCT
easat-3738	246	9	et	et	PROPN
easat-3738	246	10	al	al	PROPN
easat-3738	246	11	.	.	PROPN
easat-3738	246	12	,	,	PUNCT
easat-3738	246	13	role	role	NOUN
easat-3738	246	14	of	of	ADP
easat-3738	246	15	fas	fas	PROPN
easat-3738	246	16	and	and	CCONJ
easat-3738	246	17	treg	treg	PROPN
easat-3738	246	18	cells	cell	NOUN
easat-3738	246	19	in	in	ADP
easat-3738	246	20	fracture	fracture	NOUN
easat-3738	246	21	healing	healing	NOUN
easat-3738	246	22	as	as	ADV
easat-3738	246	23	characterized	characterize	VERB
easat-3738	246	24	in	in	ADP
easat-3738	246	25	the	the	DET
easat-3738	246	26	fas‐deficient	fas‐deficient	NOUN
easat-3738	246	27	(	(	PUNCT
easat-3738	246	28	lpr	lpr	PROPN
easat-3738	246	29	)	)	PUNCT
easat-3738	246	30	mouse	mouse	NOUN
easat-3738	246	31	model	model	NOUN
easat-3738	246	32	of	of	ADP
easat-3738	246	33	lupus	lupus	PROPN
easat-3738	246	34	.	.	PUNCT
easat-3738	247	1	journal	journal	NOUN
easat-3738	247	2	of	of	ADP
easat-3738	247	3	bone	bone	NOUN
easat-3738	247	4	and	and	CCONJ
easat-3738	247	5	mineral	mineral	NOUN
easat-3738	247	6	research	research	NOUN
easat-3738	247	7	,	,	PUNCT
easat-3738	247	8	2014	2014	NUM
easat-3738	247	9	.	.	PUNCT
easat-3738	248	1	29(6	29(6	NUM
easat-3738	248	2	):	):	PUNCT
easat-3738	248	3	p.	p.	NOUN
easat-3738	248	4	1478	1478	NUM
easat-3738	248	5	-	-	SYM
easat-3738	248	6	1491	1491	NUM
easat-3738	248	7	.	.	PUNCT
easat-3738	249	1	[	[	X
easat-3738	249	2	44	44	NUM
easat-3738	249	3	]	]	SYM
easat-3738	249	4	briot	briot	NOUN
easat-3738	249	5	,	,	PUNCT
easat-3738	249	6	k.	k.	PROPN
easat-3738	249	7	,	,	PUNCT
easat-3738	249	8	et	et	PROPN
easat-3738	249	9	al	al	PROPN
easat-3738	249	10	.	.	PROPN
easat-3738	249	11	,	,	PUNCT
easat-3738	249	12	inflammatory	inflammatory	ADJ
easat-3738	249	13	diseases	disease	NOUN
easat-3738	249	14	and	and	CCONJ
easat-3738	249	15	bone	bone	NOUN
easat-3738	249	16	fragility	fragility	NOUN
easat-3738	249	17	.	.	PUNCT
easat-3738	250	1	osteoporosis	osteoporosis	NOUN
easat-3738	250	2	international	international	ADJ
easat-3738	250	3	,	,	PUNCT
easat-3738	250	4	2017	2017	NUM
easat-3738	250	5	.	.	PUNCT
easat-3738	251	1	28	28	NUM
easat-3738	251	2	:	:	PUNCT
easat-3738	252	1	p.	p.	NOUN
easat-3738	252	2	3301	3301	NUM
easat-3738	252	3	-	-	SYM
easat-3738	252	4	3314	3314	NUM
easat-3738	252	5	.	.	PUNCT
easat-3738	253	1	[	[	X
easat-3738	253	2	45	45	NUM
easat-3738	253	3	]	]	X
easat-3738	253	4	claes	claes	PROPN
easat-3738	253	5	,	,	PUNCT
easat-3738	253	6	l.	l.	PROPN
easat-3738	253	7	,	,	PUNCT
easat-3738	253	8	s.	s.	PROPN
easat-3738	253	9	recknagel	recknagel	PROPN
easat-3738	253	10	,	,	PUNCT
easat-3738	253	11	and	and	CCONJ
easat-3738	253	12	a.	a.	NOUN
easat-3738	253	13	ignatius	ignatius	PROPN
easat-3738	253	14	,	,	PUNCT
easat-3738	253	15	fracture	fracture	NOUN
easat-3738	253	16	healing	healing	NOUN
easat-3738	253	17	under	under	ADP
easat-3738	253	18	healthy	healthy	ADJ
easat-3738	253	19	and	and	CCONJ
easat-3738	253	20	inflammatory	inflammatory	ADJ
easat-3738	253	21	conditions	condition	NOUN
easat-3738	253	22	.	.	PUNCT
easat-3738	254	1	nature	nature	NOUN
easat-3738	254	2	reviews	review	VERB
easat-3738	254	3	rheumatology	rheumatology	NOUN
easat-3738	254	4	,	,	PUNCT
easat-3738	254	5	2012	2012	NUM
easat-3738	254	6	.	.	PUNCT
easat-3738	255	1	8(3	8(3	NUM
easat-3738	255	2	):	):	PUNCT
easat-3738	256	1	p.	p.	NOUN
easat-3738	256	2	133	133	NUM
easat-3738	256	3	-	-	SYM
easat-3738	256	4	143	143	NUM
easat-3738	256	5	.	.	PUNCT
easat-3738	257	1	[	[	X
easat-3738	257	2	46	46	NUM
easat-3738	257	3	]	]	X
easat-3738	257	4	kayal	kayal	PROPN
easat-3738	257	5	,	,	PUNCT
easat-3738	257	6	r.a	r.a	PROPN
easat-3738	257	7	.	.	PROPN
easat-3738	257	8	,	,	PUNCT
easat-3738	257	9	et	et	PROPN
easat-3738	257	10	al	al	PROPN
easat-3738	257	11	.	.	PROPN
easat-3738	257	12	,	,	PUNCT
easat-3738	258	1	tnf‐α	tnf‐α	NUM
easat-3738	258	2	mediates	mediate	NOUN
easat-3738	258	3	diabetes‐enhanced	diabetes‐enhance	VERB
easat-3738	258	4	chondrocyte	chondrocyte	PROPN
easat-3738	258	5	apoptosis	apoptosis	NOUN
easat-3738	258	6	during	during	ADP
easat-3738	258	7	fracture	fracture	NOUN
easat-3738	258	8	healing	healing	NOUN
easat-3738	258	9	and	and	CCONJ
easat-3738	258	10	stimulates	stimulate	VERB
easat-3738	258	11	chondrocyte	chondrocyte	NOUN
easat-3738	258	12	apoptosis	apoptosis	NOUN
easat-3738	258	13	through	through	ADP
easat-3738	258	14	foxo1	foxo1	PROPN
easat-3738	258	15	.	.	PUNCT
easat-3738	259	1	journal	journal	PROPN
easat-3738	259	2	of	of	ADP
easat-3738	259	3	bone	bone	NOUN
easat-3738	259	4	and	and	CCONJ
easat-3738	259	5	mineral	mineral	NOUN
easat-3738	259	6	research	research	NOUN
easat-3738	259	7	,	,	PUNCT
easat-3738	259	8	2010	2010	NUM
easat-3738	259	9	.	.	PUNCT
easat-3738	260	1	25(7	25(7	NUM
easat-3738	260	2	):	):	PUNCT
easat-3738	261	1	p.	p.	NOUN
easat-3738	261	2	1604	1604	NUM
easat-3738	261	3	-	-	SYM
easat-3738	261	4	1615	1615	NUM
easat-3738	261	5	.	.	PUNCT
easat-3738	262	1	[	[	X
easat-3738	262	2	47	47	NUM
easat-3738	262	3	]	]	X
easat-3738	262	4	kayal	kayal	PROPN
easat-3738	262	5	,	,	PUNCT
easat-3738	262	6	r.a	r.a	PROPN
easat-3738	262	7	.	.	PROPN
easat-3738	262	8	,	,	PUNCT
easat-3738	262	9	et	et	PROPN
easat-3738	262	10	al	al	PROPN
easat-3738	262	11	.	.	PROPN
easat-3738	262	12	,	,	PUNCT
easat-3738	262	13	diminished	diminish	VERB
easat-3738	262	14	bone	bone	NOUN
easat-3738	262	15	formation	formation	NOUN
easat-3738	262	16	during	during	ADP
easat-3738	262	17	diabetic	diabetic	ADJ
easat-3738	262	18	fracture	fracture	NOUN
easat-3738	262	19	healing	healing	NOUN
easat-3738	262	20	is	be	AUX
easat-3738	262	21	related	relate	VERB
easat-3738	262	22	to	to	ADP
easat-3738	262	23	the	the	DET
easat-3738	262	24	premature	premature	ADJ
easat-3738	262	25	resorption	resorption	NOUN
easat-3738	262	26	of	of	ADP
easat-3738	262	27	cartilage	cartilage	NOUN
easat-3738	262	28	associated	associate	VERB
easat-3738	262	29	with	with	ADP
easat-3738	262	30	increased	increase	VERB
easat-3738	262	31	osteoclast	osteoclast	ADJ
easat-3738	262	32	activity	activity	NOUN
easat-3738	262	33	.	.	PUNCT
easat-3738	263	1	journal	journal	NOUN
easat-3738	263	2	of	of	ADP
easat-3738	263	3	bone	bone	NOUN
easat-3738	263	4	and	and	CCONJ
easat-3738	263	5	mineral	mineral	NOUN
easat-3738	263	6	research	research	NOUN
easat-3738	263	7	,	,	PUNCT
easat-3738	263	8	2007	2007	NUM
easat-3738	263	9	.	.	PUNCT
easat-3738	264	1	22(4	22(4	NUM
easat-3738	264	2	):	):	PUNCT
easat-3738	265	1	p.	p.	NOUN
easat-3738	265	2	560	560	NUM
easat-3738	265	3	-	-	SYM
easat-3738	265	4	568	568	NUM
easat-3738	265	5	.	.	PUNCT
easat-3738	266	1	https://www.medicalnewstoday.com/articles/318961	https://www.medicalnewstoday.com/articles/318961	ADJ
easat-3738	266	2	https://www.sciencedaily.com/releases/2013/03/130321092945.htm	https://www.sciencedaily.com/releases/2013/03/130321092945.htm	NOUN