id	sid	tid	token	lemma	pos
easat-8472	1	1	edelweiss	edelweiss	PROPN
easat-8472	1	2	applied	apply	VERB
easat-8472	1	3	science	science	NOUN
easat-8472	1	4	and	and	CCONJ
easat-8472	1	5	technology	technology	NOUN
easat-8472	1	6	issn	issn	PROPN
easat-8472	1	7	:	:	PUNCT
easat-8472	1	8	2576	2576	NUM
easat-8472	1	9	-	-	SYM
easat-8472	1	10	8484	8484	NUM
easat-8472	1	11	vol	vol	NOUN
easat-8472	1	12	.	.	PROPN
easat-8472	2	1	9	9	NUM
easat-8472	2	2	,	,	PUNCT
easat-8472	2	3	no	no	INTJ
easat-8472	2	4	.	.	NOUN
easat-8472	2	5	6	6	NUM
easat-8472	2	6	,	,	PUNCT
easat-8472	2	7	2774	2774	NUM
easat-8472	2	8	-	-	SYM
easat-8472	2	9	2778	2778	NUM
easat-8472	2	10	2025	2025	NUM
easat-8472	2	11	publisher	publisher	NOUN
easat-8472	2	12	:	:	PUNCT
easat-8472	2	13	learning	learn	VERB
easat-8472	2	14	gate	gate	NOUN
easat-8472	2	15	doi	doi	PROPN
easat-8472	2	16	:	:	PUNCT
easat-8472	2	17	10.55214/25768484.v9i6.8472	10.55214/25768484.v9i6.8472	NUM
easat-8472	2	18	©	©	PROPN
easat-8472	2	19	2025	2025	NUM
easat-8472	2	20	by	by	ADP
easat-8472	2	21	the	the	DET
easat-8472	2	22	authors	author	NOUN
easat-8472	2	23	;	;	PUNCT
easat-8472	2	24	licensee	licensee	PROPN
easat-8472	2	25	learning	learning	NOUN
easat-8472	2	26	gate	gate	NOUN
easat-8472	3	1	©	©	PROPN
easat-8472	3	2	2025	2025	NUM
easat-8472	3	3	by	by	ADP
easat-8472	3	4	the	the	DET
easat-8472	3	5	authors	author	NOUN
easat-8472	3	6	;	;	PUNCT
easat-8472	3	7	licensee	licensee	PROPN
easat-8472	3	8	learning	learning	NOUN
easat-8472	3	9	gate	gate	NOUN
easat-8472	3	10	history	history	NOUN
easat-8472	3	11	:	:	PUNCT
easat-8472	3	12	received	receive	VERB
easat-8472	3	13	:	:	PUNCT
easat-8472	3	14	29	29	NUM
easat-8472	3	15	april	april	PROPN
easat-8472	3	16	2025	2025	NUM
easat-8472	3	17	;	;	PUNCT
easat-8472	3	18	revised	revise	VERB
easat-8472	3	19	:	:	PUNCT
easat-8472	3	20	13	13	NUM
easat-8472	3	21	june	june	PROPN
easat-8472	3	22	2025	2025	NUM
easat-8472	3	23	;	;	PUNCT
easat-8472	3	24	accepted	accept	VERB
easat-8472	3	25	:	:	PUNCT
easat-8472	3	26	16	16	NUM
easat-8472	3	27	june	june	PROPN
easat-8472	3	28	2025	2025	NUM
easat-8472	3	29	;	;	PUNCT
easat-8472	3	30	published	publish	VERB
easat-8472	3	31	:	:	PUNCT
easat-8472	3	32	30	30	NUM
easat-8472	3	33	june	june	PROPN
easat-8472	3	34	2025	2025	NUM
easat-8472	3	35	*	*	PUNCT
easat-8472	3	36	correspondence	correspondence	NOUN
easat-8472	3	37	:	:	PUNCT
easat-8472	3	38	budhi_suryaadnyana@yahoo.com	budhi_suryaadnyana@yahoo.com	X
easat-8472	3	39	short	short	ADJ
easat-8472	3	40	-	-	PUNCT
easat-8472	3	41	term	term	NOUN
easat-8472	3	42	clinical	clinical	ADJ
easat-8472	3	43	outcome	outcome	NOUN
easat-8472	3	44	of	of	ADP
easat-8472	3	45	early	early	ADJ
easat-8472	3	46	onset	onset	VERB
easat-8472	3	47	colorectal	colorectal	ADJ
easat-8472	3	48	cancer	cancer	NOUN
easat-8472	3	49	and	and	CCONJ
easat-8472	3	50	bone	bone	NOUN
easat-8472	3	51	metastasis	metastasis	NOUN
easat-8472	3	52	progression	progression	NOUN
easat-8472	3	53	:	:	PUNCT
easat-8472	3	54	evaluation	evaluation	NOUN
easat-8472	3	55	of	of	ADP
easat-8472	3	56	zoledronic	zoledronic	ADJ
easat-8472	3	57	acid	acid	NOUN
easat-8472	3	58	effectivity	effectivity	NOUN
easat-8472	3	59	in	in	ADP
easat-8472	3	60	controlling	control	VERB
easat-8472	3	61	the	the	DET
easat-8472	3	62	skeletal	skeletal	ADJ
easat-8472	3	63	related	related	ADJ
easat-8472	3	64	events	event	NOUN
easat-8472	3	65	budhi	budhi	PROPN
easat-8472	3	66	ida	ida	PROPN
easat-8472	3	67	bagus1	bagus1	PROPN
easat-8472	3	68	*	*	PUNCT
easat-8472	3	69	,	,	PUNCT
easat-8472	3	70	hanis	hanis	NOUN
easat-8472	3	71	setyono1	setyono1	NOUN
easat-8472	3	72	,	,	PUNCT
easat-8472	3	73	wibisono1	wibisono1	PROPN
easat-8472	3	74	,	,	PUNCT
easat-8472	3	75	suwardi2	suwardi2	NOUN
easat-8472	4	1	1department	1department	NUM
easat-8472	4	2	of	of	ADP
easat-8472	4	3	surgery	surgery	NOUN
easat-8472	4	4	,	,	PUNCT
easat-8472	4	5	sebelas	sebelas	PROPN
easat-8472	4	6	maret	maret	PROPN
easat-8472	4	7	university	university	PROPN
easat-8472	4	8	,	,	PUNCT
easat-8472	4	9	indonesia	indonesia	PROPN
easat-8472	4	10	;	;	PUNCT
easat-8472	4	11	budhi_suryaadnyana@yahoo.com	budhi_suryaadnyana@yahoo.com	X
easat-8472	4	12	(	(	PUNCT
easat-8472	4	13	b.i.b	b.i.b	PROPN
easat-8472	4	14	.	.	PUNCT
easat-8472	4	15	)	)	PUNCT
easat-8472	4	16	.	.	PUNCT
easat-8472	5	1	2department	2department	NUM
easat-8472	5	2	of	of	ADP
easat-8472	5	3	surgery	surgery	NOUN
easat-8472	5	4	,	,	PUNCT
easat-8472	5	5	moewardi	moewardi	NOUN
easat-8472	5	6	general	general	ADJ
easat-8472	5	7	hospital	hospital	PROPN
easat-8472	5	8	,	,	PUNCT
easat-8472	5	9	indonesia	indonesia	PROPN
easat-8472	5	10	.	.	PUNCT
easat-8472	6	1	abstract	abstract	PROPN
easat-8472	6	2	:	:	PUNCT
easat-8472	6	3	the	the	DET
easat-8472	6	4	incidence	incidence	NOUN
easat-8472	6	5	of	of	ADP
easat-8472	6	6	early	early	ADJ
easat-8472	6	7	-	-	PUNCT
easat-8472	6	8	onset	onset	NOUN
easat-8472	6	9	colorectal	colorectal	ADJ
easat-8472	6	10	cancer	cancer	NOUN
easat-8472	6	11	(	(	PUNCT
easat-8472	6	12	eocrc	eocrc	NOUN
easat-8472	6	13	)	)	PUNCT
easat-8472	6	14	,	,	PUNCT
easat-8472	6	15	which	which	PRON
easat-8472	6	16	affects	affect	VERB
easat-8472	6	17	people	people	NOUN
easat-8472	6	18	under	under	ADP
easat-8472	6	19	50	50	NUM
easat-8472	6	20	worldwide	worldwide	ADV
easat-8472	6	21	,	,	PUNCT
easat-8472	6	22	has	have	AUX
easat-8472	6	23	increased	increase	VERB
easat-8472	6	24	by	by	ADP
easat-8472	6	25	nearly	nearly	ADV
easat-8472	6	26	30	30	NUM
easat-8472	6	27	%	%	NOUN
easat-8472	6	28	over	over	ADP
easat-8472	6	29	the	the	DET
easat-8472	6	30	past	past	ADJ
easat-8472	6	31	20	20	NUM
easat-8472	6	32	years	year	NOUN
easat-8472	6	33	,	,	PUNCT
easat-8472	6	34	particularly	particularly	ADV
easat-8472	6	35	in	in	ADP
easat-8472	6	36	high	high	ADJ
easat-8472	6	37	-	-	PUNCT
easat-8472	6	38	income	income	NOUN
easat-8472	6	39	nations	nation	NOUN
easat-8472	6	40	.	.	PUNCT
easat-8472	7	1	fifty	fifty	NUM
easat-8472	7	2	percent	percent	NOUN
easat-8472	7	3	of	of	ADP
easat-8472	7	4	patients	patient	NOUN
easat-8472	7	5	will	will	AUX
easat-8472	7	6	experience	experience	VERB
easat-8472	7	7	metastases	metastasis	NOUN
easat-8472	7	8	following	follow	VERB
easat-8472	7	9	surgical	surgical	ADJ
easat-8472	7	10	treatment	treatment	NOUN
easat-8472	7	11	of	of	ADP
easat-8472	7	12	the	the	DET
easat-8472	7	13	primary	primary	ADJ
easat-8472	7	14	tumor	tumor	NOUN
easat-8472	7	15	,	,	PUNCT
easat-8472	7	16	and	and	CCONJ
easat-8472	7	17	20	20	NUM
easat-8472	7	18	%	%	NOUN
easat-8472	7	19	have	have	VERB
easat-8472	7	20	metastatic	metastatic	ADJ
easat-8472	7	21	disease	disease	NOUN
easat-8472	7	22	at	at	ADP
easat-8472	7	23	the	the	DET
easat-8472	7	24	time	time	NOUN
easat-8472	7	25	of	of	ADP
easat-8472	7	26	diagnosis	diagnosis	NOUN
easat-8472	7	27	.	.	PUNCT
easat-8472	8	1	the	the	DET
easat-8472	8	2	main	main	ADJ
easat-8472	8	3	factors	factor	NOUN
easat-8472	8	4	associated	associate	VERB
easat-8472	8	5	with	with	ADP
easat-8472	8	6	patient	patient	ADJ
easat-8472	8	7	morbidity	morbidity	NOUN
easat-8472	8	8	are	be	AUX
easat-8472	8	9	skeletal	skeletal	ADJ
easat-8472	8	10	-	-	PUNCT
easat-8472	8	11	related	relate	VERB
easat-8472	8	12	events	event	NOUN
easat-8472	8	13	(	(	PUNCT
easat-8472	8	14	sres	sre	NOUN
easat-8472	8	15	)	)	PUNCT
easat-8472	8	16	,	,	PUNCT
easat-8472	8	17	which	which	PRON
easat-8472	8	18	frequently	frequently	ADV
easat-8472	8	19	manifest	manifest	VERB
easat-8472	8	20	as	as	ADP
easat-8472	8	21	spinal	spinal	ADJ
easat-8472	8	22	cord	cord	NOUN
easat-8472	8	23	compression	compression	NOUN
easat-8472	8	24	,	,	PUNCT
easat-8472	8	25	bone	bone	NOUN
easat-8472	8	26	pain	pain	NOUN
easat-8472	8	27	,	,	PUNCT
easat-8472	8	28	pathological	pathological	ADJ
easat-8472	8	29	fractures	fracture	NOUN
easat-8472	8	30	,	,	PUNCT
easat-8472	8	31	and	and	CCONJ
easat-8472	8	32	hypercalcemia	hypercalcemia	NOUN
easat-8472	8	33	.	.	PUNCT
easat-8472	9	1	this	this	DET
easat-8472	9	2	study	study	NOUN
easat-8472	9	3	aims	aim	VERB
easat-8472	9	4	to	to	PART
easat-8472	9	5	evaluate	evaluate	VERB
easat-8472	9	6	the	the	DET
easat-8472	9	7	short	short	ADJ
easat-8472	9	8	-	-	PUNCT
easat-8472	9	9	term	term	NOUN
easat-8472	9	10	clinical	clinical	ADJ
easat-8472	9	11	outcomes	outcome	NOUN
easat-8472	9	12	of	of	ADP
easat-8472	9	13	pharmacologic	pharmacologic	ADJ
easat-8472	9	14	treatment	treatment	NOUN
easat-8472	9	15	options	option	NOUN
easat-8472	9	16	for	for	ADP
easat-8472	9	17	bone	bone	NOUN
easat-8472	9	18	metastasis	metastasis	NOUN
easat-8472	9	19	related	relate	VERB
easat-8472	9	20	to	to	ADP
easat-8472	9	21	early	early	ADJ
easat-8472	9	22	-	-	PUNCT
easat-8472	9	23	onset	onset	NOUN
easat-8472	9	24	colorectal	colorectal	ADJ
easat-8472	9	25	cancer	cancer	NOUN
easat-8472	9	26	undergoing	undergo	VERB
easat-8472	9	27	definitive	definitive	ADJ
easat-8472	9	28	surgical	surgical	ADJ
easat-8472	9	29	resection	resection	NOUN
easat-8472	9	30	and	and	CCONJ
easat-8472	9	31	adjuvant	adjuvant	ADJ
easat-8472	9	32	chemotherapy	chemotherapy	NOUN
easat-8472	9	33	,	,	PUNCT
easat-8472	9	34	which	which	PRON
easat-8472	9	35	progresses	progress	VERB
easat-8472	9	36	to	to	ADP
easat-8472	9	37	skeletal	skeletal	ADJ
easat-8472	9	38	-	-	PUNCT
easat-8472	9	39	related	relate	VERB
easat-8472	9	40	events	event	NOUN
easat-8472	9	41	.	.	PUNCT
easat-8472	10	1	the	the	DET
easat-8472	10	2	study	study	NOUN
easat-8472	10	3	will	will	AUX
easat-8472	10	4	include	include	VERB
easat-8472	10	5	both	both	PRON
easat-8472	10	6	resectable	resectable	VERB
easat-8472	10	7	colorectal	colorectal	ADJ
easat-8472	10	8	adenocarcinomas	adenocarcinoma	NOUN
easat-8472	10	9	.	.	PUNCT
easat-8472	11	1	patients	patient	NOUN
easat-8472	11	2	with	with	ADP
easat-8472	11	3	a	a	DET
easat-8472	11	4	prior	prior	ADJ
easat-8472	11	5	history	history	NOUN
easat-8472	11	6	of	of	ADP
easat-8472	11	7	neoadjuvant	neoadjuvant	ADJ
easat-8472	11	8	chemotherapy	chemotherapy	NOUN
easat-8472	11	9	will	will	AUX
easat-8472	11	10	be	be	AUX
easat-8472	11	11	excluded	exclude	VERB
easat-8472	11	12	.	.	PUNCT
easat-8472	12	1	the	the	DET
easat-8472	12	2	primary	primary	ADJ
easat-8472	12	3	clinical	clinical	ADJ
easat-8472	12	4	outcome	outcome	NOUN
easat-8472	12	5	to	to	PART
easat-8472	12	6	be	be	AUX
easat-8472	12	7	assessed	assess	VERB
easat-8472	12	8	is	be	AUX
easat-8472	12	9	pain	pain	NOUN
easat-8472	12	10	reduction	reduction	NOUN
easat-8472	12	11	associated	associate	VERB
easat-8472	12	12	with	with	ADP
easat-8472	12	13	bone	bone	NOUN
easat-8472	12	14	metastasis	metastasis	NOUN
easat-8472	12	15	after	after	ADP
easat-8472	12	16	zoledronic	zoledronic	ADJ
easat-8472	12	17	acid	acid	NOUN
easat-8472	12	18	treatment	treatment	NOUN
easat-8472	12	19	over	over	ADP
easat-8472	12	20	six	six	NUM
easat-8472	12	21	months	month	NOUN
easat-8472	12	22	.	.	PUNCT
easat-8472	13	1	from	from	ADP
easat-8472	13	2	january	january	PROPN
easat-8472	13	3	2023	2023	NUM
easat-8472	13	4	to	to	ADP
easat-8472	13	5	january	january	PROPN
easat-8472	13	6	2025	2025	NUM
easat-8472	13	7	,	,	PUNCT
easat-8472	13	8	we	we	PRON
easat-8472	13	9	reported	report	VERB
easat-8472	13	10	15	15	NUM
easat-8472	13	11	cases	case	NOUN
easat-8472	13	12	of	of	ADP
easat-8472	13	13	early	early	ADJ
easat-8472	13	14	-	-	PUNCT
easat-8472	13	15	onset	onset	NOUN
easat-8472	13	16	colorectal	colorectal	ADJ
easat-8472	13	17	cancer	cancer	NOUN
easat-8472	13	18	that	that	PRON
easat-8472	13	19	progressed	progress	VERB
easat-8472	13	20	to	to	AUX
easat-8472	13	21	bone	bone	NOUN
easat-8472	13	22	metastasis	metastasis	NOUN
easat-8472	13	23	after	after	ADP
easat-8472	13	24	resection	resection	NOUN
easat-8472	13	25	and	and	CCONJ
easat-8472	13	26	adjuvant	adjuvant	ADJ
easat-8472	13	27	treatment	treatment	NOUN
easat-8472	13	28	.	.	PUNCT
easat-8472	14	1	seven	seven	NUM
easat-8472	14	2	cases	case	NOUN
easat-8472	14	3	involved	involve	VERB
easat-8472	14	4	sigmoid	sigmoid	NOUN
easat-8472	14	5	adenocarcinoma	adenocarcinoma	NOUN
easat-8472	14	6	.	.	PUNCT
easat-8472	15	1	the	the	DET
easat-8472	15	2	most	most	ADV
easat-8472	15	3	common	common	ADJ
easat-8472	15	4	symptom	symptom	NOUN
easat-8472	15	5	was	be	AUX
easat-8472	15	6	chronic	chronic	ADJ
easat-8472	15	7	pain	pain	NOUN
easat-8472	15	8	.	.	PUNCT
easat-8472	16	1	pain	pain	NOUN
easat-8472	16	2	levels	level	NOUN
easat-8472	16	3	,	,	PUNCT
easat-8472	16	4	measured	measure	VERB
easat-8472	16	5	by	by	ADP
easat-8472	16	6	the	the	DET
easat-8472	16	7	visual	visual	ADJ
easat-8472	16	8	analog	analog	NOUN
easat-8472	16	9	scale	scale	NOUN
easat-8472	16	10	(	(	PUNCT
easat-8472	16	11	vas	vas	NOUN
easat-8472	16	12	)	)	PUNCT
easat-8472	16	13	,	,	PUNCT
easat-8472	16	14	improved	improve	VERB
easat-8472	16	15	after	after	ADP
easat-8472	16	16	six	six	NUM
easat-8472	16	17	cycles	cycle	NOUN
easat-8472	16	18	of	of	ADP
easat-8472	16	19	zoledronic	zoledronic	ADJ
easat-8472	16	20	acid	acid	NOUN
easat-8472	16	21	treatment	treatment	NOUN
easat-8472	16	22	,	,	PUNCT
easat-8472	16	23	with	with	ADP
easat-8472	16	24	no	no	DET
easat-8472	16	25	further	further	ADJ
easat-8472	16	26	reports	report	NOUN
easat-8472	16	27	of	of	ADP
easat-8472	16	28	worsening	worsen	VERB
easat-8472	16	29	skeletal	skeletal	ADJ
easat-8472	16	30	-	-	PUNCT
easat-8472	16	31	related	relate	VERB
easat-8472	16	32	events	event	NOUN
easat-8472	16	33	.	.	PUNCT
easat-8472	17	1	early	early	ADJ
easat-8472	17	2	diagnosis	diagnosis	NOUN
easat-8472	17	3	of	of	ADP
easat-8472	17	4	colorectal	colorectal	ADJ
easat-8472	17	5	cancer	cancer	NOUN
easat-8472	17	6	is	be	AUX
easat-8472	17	7	crucial	crucial	ADJ
easat-8472	17	8	,	,	PUNCT
easat-8472	17	9	as	as	SCONJ
easat-8472	17	10	early	early	ADJ
easat-8472	17	11	-	-	PUNCT
easat-8472	17	12	onset	onset	NOUN
easat-8472	17	13	cases	case	NOUN
easat-8472	17	14	have	have	VERB
easat-8472	17	15	a	a	DET
easat-8472	17	16	higher	high	ADJ
easat-8472	17	17	likelihood	likelihood	NOUN
easat-8472	17	18	of	of	ADP
easat-8472	17	19	spreading	spread	VERB
easat-8472	17	20	to	to	ADP
easat-8472	17	21	the	the	DET
easat-8472	17	22	bones	bone	NOUN
easat-8472	17	23	.	.	PUNCT
easat-8472	18	1	pharmacologic	pharmacologic	ADJ
easat-8472	18	2	therapy	therapy	NOUN
easat-8472	18	3	demonstrates	demonstrate	VERB
easat-8472	18	4	a	a	DET
easat-8472	18	5	favorable	favorable	ADJ
easat-8472	18	6	clinical	clinical	ADJ
easat-8472	18	7	outcome	outcome	NOUN
easat-8472	18	8	in	in	ADP
easat-8472	18	9	controlling	control	VERB
easat-8472	18	10	symptoms	symptom	NOUN
easat-8472	18	11	related	relate	VERB
easat-8472	18	12	to	to	ADP
easat-8472	18	13	skeletal	skeletal	ADJ
easat-8472	18	14	-	-	PUNCT
easat-8472	18	15	related	relate	VERB
easat-8472	18	16	events	event	NOUN
easat-8472	18	17	.	.	PUNCT
easat-8472	19	1	keywords	keyword	NOUN
easat-8472	19	2	:	:	PUNCT
easat-8472	19	3	bone	bone	NOUN
easat-8472	19	4	metastasis	metastasis	NOUN
easat-8472	19	5	,	,	PUNCT
easat-8472	19	6	clinical	clinical	ADJ
easat-8472	19	7	outcome	outcome	NOUN
easat-8472	19	8	,	,	PUNCT
easat-8472	19	9	early	early	ADJ
easat-8472	19	10	onset	onset	VERB
easat-8472	19	11	colorectal	colorectal	ADJ
easat-8472	19	12	cancer	cancer	NOUN
easat-8472	19	13	,	,	PUNCT
easat-8472	19	14	zoledronic	zoledronic	ADJ
easat-8472	19	15	acid	acid	NOUN
easat-8472	19	16	.	.	PUNCT
easat-8472	20	1	1	1	X
easat-8472	20	2	.	.	X
easat-8472	20	3	introduction	introduction	NOUN
easat-8472	20	4	according	accord	VERB
easat-8472	20	5	to	to	ADP
easat-8472	20	6	fornetti	fornetti	PROPN
easat-8472	20	7	,	,	PUNCT
easat-8472	20	8	et	et	PROPN
easat-8472	20	9	al	al	PROPN
easat-8472	20	10	.	.	PUNCT
easat-8472	21	1	[	[	X
easat-8472	21	2	1	1	X
easat-8472	21	3	]	]	PUNCT
easat-8472	21	4	the	the	DET
easat-8472	21	5	incidence	incidence	NOUN
easat-8472	21	6	of	of	ADP
easat-8472	21	7	early	early	ADJ
easat-8472	21	8	-	-	PUNCT
easat-8472	21	9	onset	onset	NOUN
easat-8472	21	10	colorectal	colorectal	ADJ
easat-8472	21	11	cancer	cancer	NOUN
easat-8472	21	12	(	(	PUNCT
easat-8472	21	13	eocrc	eocrc	NOUN
easat-8472	21	14	)	)	PUNCT
easat-8472	21	15	has	have	AUX
easat-8472	21	16	climbed	climb	VERB
easat-8472	21	17	by	by	ADP
easat-8472	21	18	nearly	nearly	ADV
easat-8472	21	19	30	30	NUM
easat-8472	21	20	%	%	NOUN
easat-8472	21	21	in	in	ADP
easat-8472	21	22	the	the	DET
easat-8472	21	23	past	past	ADJ
easat-8472	21	24	20	20	NUM
easat-8472	21	25	years	year	NOUN
easat-8472	21	26	,	,	PUNCT
easat-8472	21	27	particularly	particularly	ADV
easat-8472	21	28	in	in	ADP
easat-8472	21	29	high	high	ADJ
easat-8472	21	30	-	-	PUNCT
easat-8472	21	31	income	income	NOUN
easat-8472	21	32	nations	nation	NOUN
easat-8472	21	33	such	such	ADJ
easat-8472	21	34	as	as	ADP
easat-8472	21	35	the	the	DET
easat-8472	21	36	us	us	PROPN
easat-8472	21	37	,	,	PUNCT
easat-8472	21	38	australia	australia	PROPN
easat-8472	21	39	,	,	PUNCT
easat-8472	21	40	and	and	CCONJ
easat-8472	21	41	canada	canada	PROPN
easat-8472	21	42	,	,	PUNCT
easat-8472	21	43	and	and	CCONJ
easat-8472	21	44	it	it	PRON
easat-8472	21	45	affects	affect	VERB
easat-8472	21	46	individuals	individual	NOUN
easat-8472	21	47	under	under	ADP
easat-8472	21	48	the	the	DET
easat-8472	21	49	age	age	NOUN
easat-8472	21	50	of	of	ADP
easat-8472	21	51	50	50	NUM
easat-8472	21	52	all	all	ADV
easat-8472	21	53	over	over	ADP
easat-8472	21	54	the	the	DET
easat-8472	21	55	globe	globe	NOUN
easat-8472	21	56	.	.	PUNCT
easat-8472	22	1	these	these	DET
easat-8472	22	2	incidence	incidence	ADJ
easat-8472	22	3	rates	rate	NOUN
easat-8472	22	4	of	of	ADP
easat-8472	22	5	eocrc	eocrc	NOUN
easat-8472	22	6	have	have	AUX
easat-8472	22	7	been	be	AUX
easat-8472	22	8	increasing	increase	VERB
easat-8472	22	9	at	at	ADP
easat-8472	22	10	a	a	DET
easat-8472	22	11	pace	pace	NOUN
easat-8472	22	12	of	of	ADP
easat-8472	22	13	about	about	ADV
easat-8472	22	14	2	2	NUM
easat-8472	22	15	%	%	NOUN
easat-8472	22	16	per	per	ADP
easat-8472	22	17	year	year	NOUN
easat-8472	22	18	since	since	SCONJ
easat-8472	22	19	1994	1994	NUM
easat-8472	22	20	.	.	PUNCT
easat-8472	23	1	although	although	SCONJ
easat-8472	23	2	colorectal	colorectal	ADJ
easat-8472	23	3	cancer	cancer	NOUN
easat-8472	23	4	incidence	incidence	NOUN
easat-8472	23	5	and	and	CCONJ
easat-8472	23	6	mortality	mortality	NOUN
easat-8472	23	7	rates	rate	NOUN
easat-8472	23	8	have	have	AUX
easat-8472	23	9	been	be	AUX
easat-8472	23	10	on	on	ADP
easat-8472	23	11	the	the	DET
easat-8472	23	12	decline	decline	NOUN
easat-8472	23	13	,	,	PUNCT
easat-8472	23	14	the	the	DET
easat-8472	23	15	fact	fact	NOUN
easat-8472	23	16	that	that	SCONJ
easat-8472	23	17	eocrc	eocrc	NOUN
easat-8472	23	18	is	be	AUX
easat-8472	23	19	more	more	ADV
easat-8472	23	20	common	common	ADJ
easat-8472	23	21	in	in	ADP
easat-8472	23	22	older	old	ADJ
easat-8472	23	23	adults	adult	NOUN
easat-8472	23	24	is	be	AUX
easat-8472	23	25	cause	cause	NOUN
easat-8472	23	26	for	for	ADP
easat-8472	23	27	grave	grave	ADJ
easat-8472	23	28	concern	concern	NOUN
easat-8472	23	29	,	,	PUNCT
easat-8472	23	30	as	as	SCONJ
easat-8472	23	31	indicated	indicate	VERB
easat-8472	23	32	by	by	ADP
easat-8472	23	33	holladay	holladay	PROPN
easat-8472	23	34	,	,	PUNCT
easat-8472	23	35	et	et	PROPN
easat-8472	23	36	al	al	PROPN
easat-8472	23	37	.	.	PUNCT
easat-8472	24	1	[	[	X
easat-8472	24	2	2	2	NUM
easat-8472	24	3	]	]	PUNCT
easat-8472	24	4	.	.	PUNCT
easat-8472	25	1	additionally	additionally	ADV
easat-8472	25	2	,	,	PUNCT
easat-8472	25	3	suresh	suresh	PROPN
easat-8472	25	4	,	,	PUNCT
easat-8472	25	5	et	et	PROPN
easat-8472	25	6	al	al	PROPN
easat-8472	25	7	.	.	PUNCT
easat-8472	26	1	[	[	X
easat-8472	26	2	3	3	X
easat-8472	26	3	]	]	PUNCT
easat-8472	26	4	agree	agree	VERB
easat-8472	26	5	that	that	SCONJ
easat-8472	26	6	the	the	DET
easat-8472	26	7	features	feature	NOUN
easat-8472	26	8	of	of	ADP
easat-8472	26	9	eocrc	eocrc	NOUN
easat-8472	26	10	,	,	PUNCT
easat-8472	26	11	including	include	VERB
easat-8472	26	12	its	its	PRON
easat-8472	26	13	disease	disease	NOUN
easat-8472	26	14	patterns	pattern	NOUN
easat-8472	26	15	,	,	PUNCT
easat-8472	26	16	causes	cause	NOUN
easat-8472	26	17	,	,	PUNCT
easat-8472	26	18	body	body	NOUN
easat-8472	26	19	structure	structure	NOUN
easat-8472	26	20	,	,	PUNCT
easat-8472	26	21	metabolism	metabolism	NOUN
easat-8472	26	22	,	,	PUNCT
easat-8472	26	23	and	and	CCONJ
easat-8472	26	24	biological	biological	ADJ
easat-8472	26	25	behaviour	behaviour	NOUN
easat-8472	26	26	,	,	PUNCT
easat-8472	26	27	set	set	VERB
easat-8472	26	28	it	it	PRON
easat-8472	26	29	apart	apart	ADV
easat-8472	26	30	from	from	ADP
easat-8472	26	31	late	late	ADJ
easat-8472	26	32	-	-	PUNCT
easat-8472	26	33	onset	onset	NOUN
easat-8472	26	34	colorectal	colorectal	ADJ
easat-8472	26	35	cancer	cancer	NOUN
easat-8472	26	36	(	(	PUNCT
easat-8472	26	37	locrc	locrc	NOUN
easat-8472	26	38	)	)	PUNCT
easat-8472	26	39	,	,	PUNCT
easat-8472	26	40	which	which	PRON
easat-8472	26	41	usually	usually	ADV
easat-8472	26	42	occurs	occur	VERB
easat-8472	26	43	in	in	ADP
easat-8472	26	44	people	people	NOUN
easat-8472	26	45	over	over	ADP
easat-8472	26	46	50	50	NUM
easat-8472	26	47	.	.	PUNCT
easat-8472	27	1	most	most	ADJ
easat-8472	27	2	eocrc	eocrc	NOUN
easat-8472	27	3	cases	case	NOUN
easat-8472	27	4	localise	localise	VERB
easat-8472	27	5	in	in	ADP
easat-8472	27	6	the	the	DET
easat-8472	27	7	rectum	rectum	NOUN
easat-8472	27	8	.	.	PUNCT
easat-8472	28	1	the	the	DET
easat-8472	28	2	distal	distal	ADJ
easat-8472	28	3	colon	colon	NOUN
easat-8472	28	4	is	be	AUX
easat-8472	28	5	a	a	DET
easat-8472	28	6	close	close	ADJ
easat-8472	28	7	second	second	NOUN
easat-8472	28	8	,	,	PUNCT
easat-8472	28	9	and	and	CCONJ
easat-8472	28	10	when	when	SCONJ
easat-8472	28	11	these	these	DET
easat-8472	28	12	cancers	cancer	NOUN
easat-8472	28	13	are	be	AUX
easat-8472	28	14	diagnosed	diagnose	VERB
easat-8472	28	15	,	,	PUNCT
easat-8472	28	16	more	more	ADJ
easat-8472	28	17	than	than	ADP
easat-8472	28	18	70	70	NUM
easat-8472	28	19	%	%	NOUN
easat-8472	28	20	of	of	ADP
easat-8472	28	21	them	they	PRON
easat-8472	28	22	are	be	AUX
easat-8472	28	23	found	find	VERB
easat-8472	28	24	on	on	ADP
easat-8472	28	25	the	the	DET
easat-8472	28	26	left	left	ADJ
easat-8472	28	27	side	side	NOUN
easat-8472	28	28	of	of	ADP
easat-8472	28	29	the	the	DET
easat-8472	28	30	colon	colon	NOUN
easat-8472	28	31	.	.	PUNCT
easat-8472	29	1	cancers	cancer	NOUN
easat-8472	29	2	on	on	ADP
easat-8472	29	3	the	the	DET
easat-8472	29	4	left	left	ADJ
easat-8472	29	5	side	side	NOUN
easat-8472	29	6	of	of	ADP
easat-8472	29	7	the	the	DET
easat-8472	29	8	body	body	NOUN
easat-8472	29	9	follow	follow	VERB
easat-8472	29	10	different	different	ADJ
easat-8472	29	11	treatment	treatment	NOUN
easat-8472	29	12	protocols	protocol	NOUN
easat-8472	29	13	,	,	PUNCT
easat-8472	29	14	are	be	AUX
easat-8472	29	15	smaller	small	ADJ
easat-8472	29	16	,	,	PUNCT
easat-8472	29	17	and	and	CCONJ
easat-8472	29	18	have	have	VERB
easat-8472	29	19	longer	long	ADJ
easat-8472	29	20	periods	period	NOUN
easat-8472	29	21	of	of	ADP
easat-8472	29	22	disease	disease	NOUN
easat-8472	29	23	-	-	PUNCT
easat-8472	29	24	free	free	ADJ
easat-8472	29	25	https://orcid.org/0000-0002-0310-7415	https://orcid.org/0000-0002-0310-7415	ADP
easat-8472	29	26	2775	2775	NUM
easat-8472	29	27	edelweiss	edelweiss	PROPN
easat-8472	29	28	applied	apply	VERB
easat-8472	29	29	science	science	NOUN
easat-8472	29	30	and	and	CCONJ
easat-8472	29	31	technology	technology	NOUN
easat-8472	29	32	issn	issn	PROPN
easat-8472	29	33	:	:	PUNCT
easat-8472	29	34	2576	2576	NUM
easat-8472	29	35	-	-	SYM
easat-8472	29	36	8484	8484	NUM
easat-8472	29	37	vol	vol	NOUN
easat-8472	29	38	.	.	PROPN
easat-8472	30	1	9	9	NUM
easat-8472	30	2	,	,	PUNCT
easat-8472	30	3	no	no	INTJ
easat-8472	30	4	.	.	NOUN
easat-8472	31	1	6	6	NUM
easat-8472	31	2	:	:	SYM
easat-8472	31	3	2774	2774	NUM
easat-8472	31	4	-	-	SYM
easat-8472	31	5	2778	2778	NUM
easat-8472	31	6	,	,	PUNCT
easat-8472	31	7	2025	2025	NUM
easat-8472	31	8	doi	doi	NOUN
easat-8472	31	9	:	:	PUNCT
easat-8472	31	10	10.55214/25768484.v9i6.8472	10.55214/25768484.v9i6.8472	NUM
easat-8472	31	11	©	©	PROPN
easat-8472	31	12	2025	2025	NUM
easat-8472	31	13	by	by	ADP
easat-8472	31	14	the	the	DET
easat-8472	31	15	authors	author	NOUN
easat-8472	31	16	;	;	PUNCT
easat-8472	31	17	licensee	licensee	PROPN
easat-8472	31	18	learning	learning	PROPN
easat-8472	31	19	gate	gate	PROPN
easat-8472	31	20	survival	survival	NOUN
easat-8472	31	21	than	than	ADP
easat-8472	31	22	cancers	cancer	NOUN
easat-8472	31	23	on	on	ADP
easat-8472	31	24	the	the	DET
easat-8472	31	25	right	right	ADJ
easat-8472	31	26	side	side	NOUN
easat-8472	31	27	.	.	PUNCT
easat-8472	32	1	they	they	PRON
easat-8472	32	2	also	also	ADV
easat-8472	32	3	have	have	VERB
easat-8472	32	4	lower	low	ADJ
easat-8472	32	5	recurrence	recurrence	NOUN
easat-8472	32	6	rates	rate	NOUN
easat-8472	32	7	,	,	PUNCT
easat-8472	32	8	according	accord	VERB
easat-8472	32	9	to	to	ADP
easat-8472	32	10	fornetti	fornetti	PROPN
easat-8472	32	11	,	,	PUNCT
easat-8472	32	12	et	et	PROPN
easat-8472	32	13	al	al	PROPN
easat-8472	32	14	.	.	PUNCT
easat-8472	33	1	[	[	X
easat-8472	33	2	1	1	X
easat-8472	33	3	]	]	PUNCT
easat-8472	33	4	and	and	CCONJ
easat-8472	33	5	suresh	suresh	PROPN
easat-8472	33	6	,	,	PUNCT
easat-8472	33	7	et	et	PROPN
easat-8472	33	8	al	al	PROPN
easat-8472	33	9	.	.	PUNCT
easat-8472	34	1	[	[	X
easat-8472	34	2	3	3	NUM
easat-8472	34	3	]	]	PUNCT
easat-8472	34	4	.	.	PUNCT
easat-8472	35	1	when	when	SCONJ
easat-8472	35	2	it	it	PRON
easat-8472	35	3	comes	come	VERB
easat-8472	35	4	to	to	ADP
easat-8472	35	5	nonspecific	nonspecific	ADJ
easat-8472	35	6	clinical	clinical	ADJ
easat-8472	35	7	symptoms	symptom	NOUN
easat-8472	35	8	,	,	PUNCT
easat-8472	35	9	younger	young	ADJ
easat-8472	35	10	patients	patient	NOUN
easat-8472	35	11	are	be	AUX
easat-8472	35	12	more	more	ADV
easat-8472	35	13	likely	likely	ADJ
easat-8472	35	14	to	to	PART
easat-8472	35	15	be	be	AUX
easat-8472	35	16	dismissive	dismissive	ADJ
easat-8472	35	17	.	.	PUNCT
easat-8472	36	1	most	most	ADJ
easat-8472	36	2	people	people	NOUN
easat-8472	36	3	do	do	AUX
easat-8472	36	4	n't	not	PART
easat-8472	36	5	pay	pay	VERB
easat-8472	36	6	much	much	ADJ
easat-8472	36	7	attention	attention	NOUN
easat-8472	36	8	to	to	ADP
easat-8472	36	9	common	common	ADJ
easat-8472	36	10	ones	one	NOUN
easat-8472	36	11	that	that	PRON
easat-8472	36	12	are	be	AUX
easat-8472	36	13	linked	link	VERB
easat-8472	36	14	to	to	ADP
easat-8472	36	15	colorectal	colorectal	ADJ
easat-8472	36	16	cancer	cancer	NOUN
easat-8472	36	17	,	,	PUNCT
easat-8472	36	18	like	like	ADP
easat-8472	36	19	a	a	DET
easat-8472	36	20	loss	loss	NOUN
easat-8472	36	21	of	of	ADP
easat-8472	36	22	appetite	appetite	NOUN
easat-8472	36	23	,	,	PUNCT
easat-8472	36	24	stomach	stomach	NOUN
easat-8472	36	25	pain	pain	NOUN
easat-8472	36	26	,	,	PUNCT
easat-8472	36	27	and	and	CCONJ
easat-8472	36	28	weight	weight	NOUN
easat-8472	36	29	loss	loss	NOUN
easat-8472	36	30	.	.	PUNCT
easat-8472	37	1	this	this	DET
easat-8472	37	2	procedure	procedure	NOUN
easat-8472	37	3	delays	delay	VERB
easat-8472	37	4	the	the	DET
easat-8472	37	5	diagnosis	diagnosis	NOUN
easat-8472	37	6	by	by	ADP
easat-8472	37	7	approximately	approximately	ADV
easat-8472	37	8	6	6	NUM
easat-8472	37	9	to	to	PART
easat-8472	37	10	9	9	NUM
easat-8472	37	11	months	month	NOUN
easat-8472	37	12	.	.	PUNCT
easat-8472	38	1	colorectal	colorectal	ADJ
easat-8472	38	2	cancer	cancer	NOUN
easat-8472	38	3	symptoms	symptom	NOUN
easat-8472	38	4	typically	typically	ADV
easat-8472	38	5	signal	signal	VERB
easat-8472	38	6	a	a	DET
easat-8472	38	7	more	more	ADV
easat-8472	38	8	advanced	advanced	ADJ
easat-8472	38	9	stage	stage	NOUN
easat-8472	38	10	of	of	ADP
easat-8472	38	11	the	the	DET
easat-8472	38	12	disease	disease	NOUN
easat-8472	38	13	,	,	PUNCT
easat-8472	38	14	which	which	PRON
easat-8472	38	15	is	be	AUX
easat-8472	38	16	associated	associate	VERB
easat-8472	38	17	with	with	ADP
easat-8472	38	18	a	a	DET
easat-8472	38	19	worse	bad	ADJ
easat-8472	38	20	prognosis	prognosis	NOUN
easat-8472	38	21	.	.	PUNCT
easat-8472	39	1	a	a	DET
easat-8472	39	2	study	study	NOUN
easat-8472	39	3	by	by	ADP
easat-8472	39	4	assi	assi	NOUN
easat-8472	39	5	,	,	PUNCT
easat-8472	39	6	et	et	PROPN
easat-8472	39	7	al	al	PROPN
easat-8472	39	8	.	.	PUNCT
easat-8472	40	1	[	[	X
easat-8472	40	2	4	4	X
easat-8472	40	3	]	]	PUNCT
easat-8472	40	4	found	find	VERB
easat-8472	40	5	that	that	SCONJ
easat-8472	40	6	more	more	ADJ
easat-8472	40	7	than	than	ADP
easat-8472	40	8	61	61	NUM
easat-8472	40	9	%	%	NOUN
easat-8472	40	10	of	of	ADP
easat-8472	40	11	eocrc	eocrc	NOUN
easat-8472	40	12	patients	patient	NOUN
easat-8472	40	13	had	have	VERB
easat-8472	40	14	metastatic	metastatic	ADJ
easat-8472	40	15	disease	disease	NOUN
easat-8472	40	16	,	,	PUNCT
easat-8472	40	17	which	which	PRON
easat-8472	40	18	is	be	AUX
easat-8472	40	19	higher	high	ADJ
easat-8472	40	20	than	than	ADP
easat-8472	40	21	in	in	ADP
easat-8472	40	22	locrc	locrc	NOUN
easat-8472	40	23	patients	patient	NOUN
easat-8472	40	24	.	.	PUNCT
easat-8472	41	1	finally	finally	ADV
easat-8472	41	2	,	,	PUNCT
easat-8472	41	3	holladay	holladay	PROPN
easat-8472	41	4	,	,	PUNCT
easat-8472	41	5	et	et	PROPN
easat-8472	41	6	al	al	PROPN
easat-8472	41	7	.	.	PUNCT
easat-8472	42	1	[	[	X
easat-8472	42	2	2	2	X
easat-8472	42	3	]	]	PUNCT
easat-8472	42	4	reported	report	VERB
easat-8472	42	5	on	on	ADP
easat-8472	42	6	the	the	DET
easat-8472	42	7	treatment	treatment	NOUN
easat-8472	42	8	aspect	aspect	NOUN
easat-8472	42	9	.	.	PUNCT
easat-8472	43	1	eocrc	eocrc	NOUN
easat-8472	43	2	and	and	CCONJ
easat-8472	43	3	locrc	locrc	NOUN
easat-8472	43	4	are	be	AUX
easat-8472	43	5	very	very	ADV
easat-8472	43	6	similar	similar	ADJ
easat-8472	43	7	;	;	PUNCT
easat-8472	43	8	the	the	DET
easat-8472	43	9	only	only	ADJ
easat-8472	43	10	difference	difference	NOUN
easat-8472	43	11	is	be	AUX
easat-8472	43	12	that	that	SCONJ
easat-8472	43	13	patients	patient	NOUN
easat-8472	43	14	under	under	ADP
easat-8472	43	15	the	the	DET
easat-8472	43	16	age	age	NOUN
easat-8472	43	17	of	of	ADP
easat-8472	43	18	50	50	NUM
easat-8472	43	19	are	be	AUX
easat-8472	43	20	more	more	ADV
easat-8472	43	21	likely	likely	ADJ
easat-8472	43	22	to	to	PART
easat-8472	43	23	receive	receive	VERB
easat-8472	43	24	and	and	CCONJ
easat-8472	43	25	have	have	VERB
easat-8472	43	26	better	well	ADJ
easat-8472	43	27	postoperative	postoperative	ADJ
easat-8472	43	28	tolerance	tolerance	NOUN
easat-8472	43	29	of	of	ADP
easat-8472	43	30	treatment	treatment	NOUN
easat-8472	43	31	.	.	PUNCT
easat-8472	44	1	the	the	DET
easat-8472	44	2	goal	goal	NOUN
easat-8472	44	3	of	of	ADP
easat-8472	44	4	the	the	DET
easat-8472	44	5	international	international	ADJ
easat-8472	44	6	multidisciplinary	multidisciplinary	ADJ
easat-8472	44	7	team	team	NOUN
easat-8472	44	8	known	know	VERB
easat-8472	44	9	as	as	ADP
easat-8472	44	10	direct	direct	ADJ
easat-8472	44	11	was	be	AUX
easat-8472	44	12	to	to	PART
easat-8472	44	13	help	help	VERB
easat-8472	44	14	clinicians	clinician	NOUN
easat-8472	44	15	treat	treat	VERB
easat-8472	44	16	patients	patient	NOUN
easat-8472	44	17	with	with	ADP
easat-8472	44	18	eocrc	eocrc	NOUN
easat-8472	44	19	by	by	ADP
easat-8472	44	20	compiling	compile	VERB
easat-8472	44	21	evidence	evidence	NOUN
easat-8472	44	22	-	-	PUNCT
easat-8472	44	23	based	base	VERB
easat-8472	44	24	guidelines	guideline	NOUN
easat-8472	44	25	.	.	PUNCT
easat-8472	45	1	compared	compare	VERB
easat-8472	45	2	to	to	ADP
easat-8472	45	3	cancers	cancer	NOUN
easat-8472	45	4	of	of	ADP
easat-8472	45	5	the	the	DET
easat-8472	45	6	prostate	prostate	NOUN
easat-8472	45	7	or	or	CCONJ
easat-8472	45	8	breast	breast	NOUN
easat-8472	45	9	,	,	PUNCT
easat-8472	45	10	colorectal	colorectal	ADJ
easat-8472	45	11	cancer	cancer	NOUN
easat-8472	45	12	has	have	VERB
easat-8472	45	13	a	a	DET
easat-8472	45	14	far	far	ADV
easat-8472	45	15	lower	low	ADJ
easat-8472	45	16	incidence	incidence	NOUN
easat-8472	45	17	of	of	ADP
easat-8472	45	18	bone	bone	NOUN
easat-8472	45	19	metastasis	metastasis	NOUN
easat-8472	45	20	(	(	PUNCT
easat-8472	45	21	less	less	ADJ
easat-8472	45	22	than	than	ADP
easat-8472	45	23	10	10	NUM
easat-8472	45	24	%	%	NOUN
easat-8472	45	25	of	of	ADP
easat-8472	45	26	patients	patient	NOUN
easat-8472	45	27	)	)	PUNCT
easat-8472	45	28	.	.	PUNCT
easat-8472	46	1	the	the	DET
easat-8472	46	2	most	most	ADV
easat-8472	46	3	common	common	ADJ
easat-8472	46	4	places	place	NOUN
easat-8472	46	5	for	for	ADP
easat-8472	46	6	bone	bone	NOUN
easat-8472	46	7	metastasis	metastasis	NOUN
easat-8472	46	8	caused	cause	VERB
easat-8472	46	9	by	by	ADP
easat-8472	46	10	colorectal	colorectal	ADJ
easat-8472	46	11	cancer	cancer	NOUN
easat-8472	46	12	to	to	PART
easat-8472	46	13	occur	occur	VERB
easat-8472	46	14	are	be	AUX
easat-8472	46	15	the	the	DET
easat-8472	46	16	spine	spine	NOUN
easat-8472	46	17	(	(	PUNCT
easat-8472	46	18	65	65	NUM
easat-8472	46	19	%	%	NOUN
easat-8472	46	20	)	)	PUNCT
easat-8472	46	21	,	,	PUNCT
easat-8472	46	22	pelvis	pelvi	NOUN
easat-8472	46	23	or	or	CCONJ
easat-8472	46	24	hip	hip	NOUN
easat-8472	46	25	(	(	PUNCT
easat-8472	46	26	34	34	NUM
easat-8472	46	27	%	%	NOUN
easat-8472	46	28	)	)	PUNCT
easat-8472	46	29	,	,	PUNCT
easat-8472	46	30	long	long	ADJ
easat-8472	46	31	bones	bone	NOUN
easat-8472	46	32	(	(	PUNCT
easat-8472	46	33	26	26	NUM
easat-8472	46	34	%	%	NOUN
easat-8472	46	35	)	)	PUNCT
easat-8472	46	36	,	,	PUNCT
easat-8472	46	37	and	and	CCONJ
easat-8472	46	38	other	other	ADJ
easat-8472	46	39	bone	bone	NOUN
easat-8472	46	40	sites	site	NOUN
easat-8472	46	41	(	(	PUNCT
easat-8472	46	42	17	17	NUM
easat-8472	46	43	%	%	NOUN
easat-8472	46	44	)	)	PUNCT
easat-8472	46	45	,	,	PUNCT
easat-8472	46	46	as	as	SCONJ
easat-8472	46	47	indicated	indicate	VERB
easat-8472	46	48	by	by	ADP
easat-8472	46	49	park	park	NOUN
easat-8472	46	50	,	,	PUNCT
easat-8472	46	51	et	et	PROPN
easat-8472	46	52	al	al	PROPN
easat-8472	46	53	.	.	PUNCT
easat-8472	47	1	[	[	X
easat-8472	47	2	5	5	NUM
easat-8472	47	3	]	]	PUNCT
easat-8472	47	4	.	.	PUNCT
easat-8472	48	1	furthermore	furthermore	ADV
easat-8472	48	2	,	,	PUNCT
easat-8472	48	3	according	accord	VERB
easat-8472	48	4	to	to	ADP
easat-8472	48	5	li	li	PROPN
easat-8472	48	6	,	,	PUNCT
easat-8472	48	7	et	et	PROPN
easat-8472	48	8	al	al	PROPN
easat-8472	48	9	.	.	PUNCT
easat-8472	49	1	[	[	X
easat-8472	49	2	6	6	NUM
easat-8472	49	3	]	]	PUNCT
easat-8472	49	4	individuals	individual	NOUN
easat-8472	49	5	under	under	ADP
easat-8472	49	6	the	the	DET
easat-8472	49	7	age	age	NOUN
easat-8472	49	8	of	of	ADP
easat-8472	49	9	60	60	NUM
easat-8472	49	10	may	may	AUX
easat-8472	49	11	also	also	ADV
easat-8472	49	12	face	face	VERB
easat-8472	49	13	an	an	DET
easat-8472	49	14	elevated	elevated	ADJ
easat-8472	49	15	risk	risk	NOUN
easat-8472	49	16	,	,	PUNCT
easat-8472	49	17	although	although	SCONJ
easat-8472	49	18	the	the	DET
easat-8472	49	19	increase	increase	NOUN
easat-8472	49	20	may	may	AUX
easat-8472	49	21	be	be	AUX
easat-8472	49	22	linked	link	VERB
easat-8472	49	23	to	to	ADP
easat-8472	49	24	a	a	DET
easat-8472	49	25	more	more	ADV
easat-8472	49	26	aggressive	aggressive	ADJ
easat-8472	49	27	form	form	NOUN
easat-8472	49	28	of	of	ADP
easat-8472	49	29	colorectal	colorectal	ADJ
easat-8472	49	30	cancer	cancer	NOUN
easat-8472	49	31	rather	rather	ADV
easat-8472	49	32	than	than	ADP
easat-8472	49	33	solely	solely	ADV
easat-8472	49	34	to	to	ADP
easat-8472	49	35	age	age	NOUN
easat-8472	49	36	.	.	PUNCT
easat-8472	50	1	research	research	NOUN
easat-8472	50	2	indicates	indicate	VERB
easat-8472	50	3	that	that	SCONJ
easat-8472	50	4	the	the	DET
easat-8472	50	5	emergence	emergence	NOUN
easat-8472	50	6	of	of	ADP
easat-8472	50	7	bone	bone	NOUN
easat-8472	50	8	metastasis	metastasis	NOUN
easat-8472	50	9	is	be	AUX
easat-8472	50	10	associated	associate	VERB
easat-8472	50	11	with	with	ADP
easat-8472	50	12	resistant	resistant	ADJ
easat-8472	50	13	lung	lung	NOUN
easat-8472	50	14	metastasis	metastasis	NOUN
easat-8472	50	15	.	.	PUNCT
easat-8472	51	1	risk	risk	NOUN
easat-8472	51	2	factors	factor	NOUN
easat-8472	51	3	include	include	VERB
easat-8472	51	4	rectal	rectal	ADJ
easat-8472	51	5	cancer	cancer	NOUN
easat-8472	51	6	,	,	PUNCT
easat-8472	51	7	signet	signet	NOUN
easat-8472	51	8	-	-	PUNCT
easat-8472	51	9	ring	ring	NOUN
easat-8472	51	10	cell	cell	NOUN
easat-8472	51	11	carcinoma	carcinoma	NOUN
easat-8472	51	12	,	,	PUNCT
easat-8472	51	13	the	the	DET
easat-8472	51	14	size	size	NOUN
easat-8472	51	15	of	of	ADP
easat-8472	51	16	crc	crc	NOUN
easat-8472	51	17	tumours	tumour	NOUN
easat-8472	51	18	,	,	PUNCT
easat-8472	51	19	and	and	CCONJ
easat-8472	51	20	spread	spread	VERB
easat-8472	51	21	to	to	ADP
easat-8472	51	22	lymph	lymph	NOUN
easat-8472	51	23	nodes	node	NOUN
easat-8472	51	24	,	,	PUNCT
easat-8472	51	25	liver	liver	NOUN
easat-8472	51	26	,	,	PUNCT
easat-8472	51	27	and	and	CCONJ
easat-8472	51	28	brain	brain	NOUN
easat-8472	51	29	,	,	PUNCT
easat-8472	51	30	as	as	ADV
easat-8472	51	31	well	well	ADV
easat-8472	51	32	as	as	ADP
easat-8472	51	33	high	high	ADJ
easat-8472	51	34	levels	level	NOUN
easat-8472	51	35	of	of	ADP
easat-8472	51	36	carcinoembryonic	carcinoembryonic	ADJ
easat-8472	51	37	antigen	antigen	NOUN
easat-8472	51	38	(	(	PUNCT
easat-8472	51	39	cea	cea	PROPN
easat-8472	51	40	)	)	PUNCT
easat-8472	51	41	.	.	PUNCT
easat-8472	52	1	a	a	DET
easat-8472	52	2	patient	patient	NOUN
easat-8472	52	3	's	's	PART
easat-8472	52	4	morbidity	morbidity	NOUN
easat-8472	52	5	is	be	AUX
easat-8472	52	6	mainly	mainly	ADV
easat-8472	52	7	influenced	influence	VERB
easat-8472	52	8	by	by	ADP
easat-8472	52	9	skeletal	skeletal	ADJ
easat-8472	52	10	-	-	PUNCT
easat-8472	52	11	related	relate	VERB
easat-8472	52	12	events	event	NOUN
easat-8472	52	13	(	(	PUNCT
easat-8472	52	14	sres	sre	NOUN
easat-8472	52	15	)	)	PUNCT
easat-8472	52	16	.	.	PUNCT
easat-8472	53	1	compression	compression	NOUN
easat-8472	53	2	of	of	ADP
easat-8472	53	3	the	the	DET
easat-8472	53	4	spinal	spinal	NOUN
easat-8472	53	5	cord	cord	NOUN
easat-8472	53	6	,	,	PUNCT
easat-8472	53	7	bone	bone	NOUN
easat-8472	53	8	pain	pain	NOUN
easat-8472	53	9	,	,	PUNCT
easat-8472	53	10	pathologic	pathologic	ADJ
easat-8472	53	11	nail	nail	NOUN
easat-8472	53	12	fractures	fracture	NOUN
easat-8472	53	13	,	,	PUNCT
easat-8472	53	14	and	and	CCONJ
easat-8472	53	15	hypercalcemia	hypercalcemia	NOUN
easat-8472	53	16	are	be	AUX
easat-8472	53	17	common	common	ADJ
easat-8472	53	18	symptoms	symptom	NOUN
easat-8472	53	19	of	of	ADP
easat-8472	53	20	sres	sre	NOUN
easat-8472	53	21	in	in	ADP
easat-8472	53	22	the	the	DET
easat-8472	53	23	metastasis	metastasis	NOUN
easat-8472	53	24	of	of	ADP
easat-8472	53	25	colorectal	colorectal	ADJ
easat-8472	53	26	cancer	cancer	NOUN
easat-8472	53	27	.	.	PUNCT
easat-8472	54	1	these	these	DET
easat-8472	54	2	occurrences	occurrence	NOUN
easat-8472	54	3	are	be	AUX
easat-8472	54	4	all	all	PRON
easat-8472	54	5	associated	associate	VERB
easat-8472	54	6	with	with	ADP
easat-8472	54	7	a	a	DET
easat-8472	54	8	decline	decline	NOUN
easat-8472	54	9	in	in	ADP
easat-8472	54	10	quality	quality	NOUN
easat-8472	54	11	of	of	ADP
easat-8472	54	12	life	life	NOUN
easat-8472	54	13	,	,	PUNCT
easat-8472	54	14	the	the	DET
easat-8472	54	15	need	need	NOUN
easat-8472	54	16	for	for	ADP
easat-8472	54	17	supportive	supportive	ADJ
easat-8472	54	18	care	care	NOUN
easat-8472	54	19	,	,	PUNCT
easat-8472	54	20	a	a	DET
easat-8472	54	21	drop	drop	NOUN
easat-8472	54	22	in	in	ADP
easat-8472	54	23	survival	survival	NOUN
easat-8472	54	24	rate	rate	NOUN
easat-8472	54	25	,	,	PUNCT
easat-8472	54	26	and	and	CCONJ
easat-8472	54	27	the	the	DET
easat-8472	54	28	end	end	NOUN
easat-8472	54	29	of	of	ADP
easat-8472	54	30	systemic	systemic	ADJ
easat-8472	54	31	chemotherapy	chemotherapy	NOUN
easat-8472	54	32	.	.	PUNCT
easat-8472	55	1	nerves	nerve	NOUN
easat-8472	55	2	close	close	ADJ
easat-8472	55	3	to	to	ADP
easat-8472	55	4	a	a	DET
easat-8472	55	5	bone	bone	NOUN
easat-8472	55	6	tumour	tumour	NOUN
easat-8472	55	7	may	may	AUX
easat-8472	55	8	overreact	overreact	VERB
easat-8472	55	9	to	to	PART
easat-8472	55	10	stimuli	stimulus	NOUN
easat-8472	55	11	,	,	PUNCT
easat-8472	55	12	leading	lead	VERB
easat-8472	55	13	to	to	ADP
easat-8472	55	14	excruciating	excruciating	ADJ
easat-8472	55	15	pain	pain	NOUN
easat-8472	55	16	,	,	PUNCT
easat-8472	55	17	because	because	SCONJ
easat-8472	55	18	the	the	DET
easat-8472	55	19	tumour	tumour	NOUN
easat-8472	55	20	alters	alter	VERB
easat-8472	55	21	the	the	DET
easat-8472	55	22	environment	environment	NOUN
easat-8472	55	23	around	around	ADP
easat-8472	55	24	it	it	PRON
easat-8472	55	25	.	.	PUNCT
easat-8472	56	1	kawamura	kawamura	PROPN
easat-8472	56	2	,	,	PUNCT
easat-8472	56	3	et	et	PROPN
easat-8472	56	4	al	al	PROPN
easat-8472	56	5	.	.	PUNCT
easat-8472	57	1	[	[	X
easat-8472	57	2	7	7	X
easat-8472	57	3	]	]	PUNCT
easat-8472	57	4	state	state	NOUN
easat-8472	57	5	that	that	SCONJ
easat-8472	57	6	the	the	DET
easat-8472	57	7	initial	initial	ADJ
easat-8472	57	8	indication	indication	NOUN
easat-8472	57	9	of	of	ADP
easat-8472	57	10	bone	bone	NOUN
easat-8472	57	11	metastasis	metastasis	NOUN
easat-8472	57	12	is	be	AUX
easat-8472	57	13	usually	usually	ADV
easat-8472	57	14	the	the	DET
easat-8472	57	15	presence	presence	NOUN
easat-8472	57	16	of	of	ADP
easat-8472	57	17	pain	pain	NOUN
easat-8472	57	18	.	.	PUNCT
easat-8472	58	1	osteolytic	osteolytic	ADJ
easat-8472	58	2	,	,	PUNCT
easat-8472	58	3	osteoblastic	osteoblastic	ADJ
easat-8472	58	4	,	,	PUNCT
easat-8472	58	5	and	and	CCONJ
easat-8472	58	6	mixed	mixed	ADJ
easat-8472	58	7	metastatic	metastatic	ADJ
easat-8472	58	8	bone	bone	NOUN
easat-8472	58	9	lesions	lesion	NOUN
easat-8472	58	10	are	be	AUX
easat-8472	58	11	the	the	DET
easat-8472	58	12	three	three	NUM
easat-8472	58	13	main	main	ADJ
easat-8472	58	14	types	type	NOUN
easat-8472	58	15	.	.	PUNCT
easat-8472	59	1	typically	typically	ADV
easat-8472	59	2	,	,	PUNCT
easat-8472	59	3	osteolytic	osteolytic	ADJ
easat-8472	59	4	lesions	lesion	NOUN
easat-8472	59	5	are	be	AUX
easat-8472	59	6	found	find	VERB
easat-8472	59	7	in	in	ADP
easat-8472	59	8	cases	case	NOUN
easat-8472	59	9	of	of	ADP
easat-8472	59	10	colorectal	colorectal	ADJ
easat-8472	59	11	cancer	cancer	NOUN
easat-8472	59	12	.	.	PUNCT
easat-8472	60	1	osteoclasts	osteoclast	NOUN
easat-8472	60	2	cause	cause	VERB
easat-8472	60	3	these	these	DET
easat-8472	60	4	lesions	lesion	NOUN
easat-8472	60	5	.	.	PUNCT
easat-8472	61	1	increased	increase	VERB
easat-8472	61	2	numbers	number	NOUN
easat-8472	61	3	of	of	ADP
easat-8472	61	4	osteoclasts	osteoclast	NOUN
easat-8472	61	5	and	and	CCONJ
easat-8472	61	6	progenitor	progenitor	NOUN
easat-8472	61	7	osteoclast	osteoclast	ADJ
easat-8472	61	8	cells	cell	NOUN
easat-8472	61	9	,	,	PUNCT
easat-8472	61	10	a	a	DET
easat-8472	61	11	process	process	NOUN
easat-8472	61	12	known	know	VERB
easat-8472	61	13	as	as	ADP
easat-8472	61	14	osteoclastogenesis	osteoclastogenesis	NOUN
easat-8472	61	15	,	,	PUNCT
easat-8472	61	16	exacerbate	exacerbate	VERB
easat-8472	61	17	bone	bone	NOUN
easat-8472	61	18	resorption	resorption	NOUN
easat-8472	61	19	.	.	PUNCT
easat-8472	62	1	patients	patient	NOUN
easat-8472	62	2	whose	whose	DET
easat-8472	62	3	cancer	cancer	NOUN
easat-8472	62	4	has	have	AUX
easat-8472	62	5	spread	spread	VERB
easat-8472	62	6	to	to	ADP
easat-8472	62	7	their	their	PRON
easat-8472	62	8	bones	bone	NOUN
easat-8472	62	9	can	can	AUX
easat-8472	62	10	receive	receive	VERB
easat-8472	62	11	treatment	treatment	NOUN
easat-8472	62	12	based	base	VERB
easat-8472	62	13	on	on	ADP
easat-8472	62	14	either	either	CCONJ
easat-8472	62	15	systemic	systemic	ADJ
easat-8472	62	16	or	or	CCONJ
easat-8472	62	17	local	local	ADJ
easat-8472	62	18	control	control	NOUN
easat-8472	62	19	.	.	PUNCT
easat-8472	63	1	reducing	reduce	VERB
easat-8472	63	2	skeletal	skeletal	ADJ
easat-8472	63	3	-	-	PUNCT
easat-8472	63	4	related	relate	VERB
easat-8472	63	5	events	event	NOUN
easat-8472	63	6	(	(	PUNCT
easat-8472	63	7	sres	sre	NOUN
easat-8472	63	8	)	)	PUNCT
easat-8472	63	9	and	and	CCONJ
easat-8472	63	10	controlling	control	VERB
easat-8472	63	11	the	the	DET
easat-8472	63	12	progression	progression	NOUN
easat-8472	63	13	of	of	ADP
easat-8472	63	14	metastasis	metastasis	NOUN
easat-8472	63	15	are	be	AUX
easat-8472	63	16	the	the	DET
easat-8472	63	17	goals	goal	NOUN
easat-8472	63	18	of	of	ADP
easat-8472	63	19	systemic	systemic	ADJ
easat-8472	63	20	treatment	treatment	NOUN
easat-8472	63	21	.	.	PUNCT
easat-8472	64	1	patients	patient	NOUN
easat-8472	64	2	with	with	ADP
easat-8472	64	3	a	a	DET
easat-8472	64	4	prognosis	prognosis	NOUN
easat-8472	64	5	of	of	ADP
easat-8472	64	6	at	at	ADV
easat-8472	64	7	least	least	ADV
easat-8472	64	8	six	six	NUM
easat-8472	64	9	weeks	week	NOUN
easat-8472	64	10	can	can	AUX
easat-8472	64	11	benefit	benefit	VERB
easat-8472	64	12	from	from	ADP
easat-8472	64	13	localised	localised	ADJ
easat-8472	64	14	treatment	treatment	NOUN
easat-8472	64	15	,	,	PUNCT
easat-8472	64	16	which	which	PRON
easat-8472	64	17	focusses	focusse	VERB
easat-8472	64	18	on	on	ADP
easat-8472	64	19	stabilising	stabilise	VERB
easat-8472	64	20	bones	bone	NOUN
easat-8472	64	21	and	and	CCONJ
easat-8472	64	22	seeks	seek	VERB
easat-8472	64	23	to	to	PART
easat-8472	64	24	improve	improve	VERB
easat-8472	64	25	localised	localised	ADJ
easat-8472	64	26	lesions	lesion	NOUN
easat-8472	64	27	.	.	PUNCT
easat-8472	65	1	a	a	DET
easat-8472	65	2	patient	patient	NOUN
easat-8472	65	3	's	's	PART
easat-8472	65	4	prognosis	prognosis	NOUN
easat-8472	65	5	,	,	PUNCT
easat-8472	65	6	pain	pain	NOUN
easat-8472	65	7	management	management	NOUN
easat-8472	65	8	capabilities	capability	NOUN
easat-8472	65	9	,	,	PUNCT
easat-8472	65	10	life	life	NOUN
easat-8472	65	11	expectancy	expectancy	NOUN
easat-8472	65	12	,	,	PUNCT
easat-8472	65	13	tumour	tumour	ADJ
easat-8472	65	14	localisation	localisation	NOUN
easat-8472	65	15	,	,	PUNCT
easat-8472	65	16	staging	staging	NOUN
easat-8472	65	17	,	,	PUNCT
easat-8472	65	18	and	and	CCONJ
easat-8472	65	19	other	other	ADJ
easat-8472	65	20	relevant	relevant	ADJ
easat-8472	65	21	factors	factor	NOUN
easat-8472	65	22	should	should	AUX
easat-8472	65	23	inform	inform	VERB
easat-8472	65	24	treatment	treatment	NOUN
easat-8472	65	25	decisions	decision	NOUN
easat-8472	65	26	,	,	PUNCT
easat-8472	65	27	as	as	SCONJ
easat-8472	65	28	indicated	indicate	VERB
easat-8472	65	29	by	by	ADP
easat-8472	65	30	kawamura	kawamura	PROPN
easat-8472	65	31	,	,	PUNCT
easat-8472	65	32	et	et	PROPN
easat-8472	65	33	al	al	PROPN
easat-8472	65	34	.	.	PUNCT
easat-8472	66	1	[	[	X
easat-8472	66	2	7	7	NUM
easat-8472	66	3	]	]	PUNCT
easat-8472	66	4	;	;	PUNCT
easat-8472	66	5	ma	ma	PROPN
easat-8472	66	6	,	,	PUNCT
easat-8472	66	7	et	et	PROPN
easat-8472	66	8	al	al	PROPN
easat-8472	66	9	.	.	PUNCT
easat-8472	67	1	[	[	X
easat-8472	67	2	8	8	NUM
easat-8472	67	3	]	]	PUNCT
easat-8472	67	4	and	and	CCONJ
easat-8472	67	5	li	li	PROPN
easat-8472	67	6	,	,	PUNCT
easat-8472	67	7	et	et	PROPN
easat-8472	67	8	al	al	PROPN
easat-8472	67	9	.	.	PUNCT
easat-8472	68	1	[	[	X
easat-8472	68	2	9	9	NUM
easat-8472	68	3	]	]	SYM
easat-8472	68	4	.	.	PUNCT
easat-8472	69	1	2	2	X
easat-8472	69	2	.	.	X
easat-8472	69	3	methods	method	NOUN
easat-8472	69	4	the	the	DET
easat-8472	69	5	surgery	surgery	NOUN
easat-8472	69	6	department	department	NOUN
easat-8472	69	7	of	of	ADP
easat-8472	69	8	moewardi	moewardi	PROPN
easat-8472	69	9	general	general	PROPN
easat-8472	69	10	hospital	hospital	PROPN
easat-8472	69	11	in	in	ADP
easat-8472	69	12	indonesia	indonesia	PROPN
easat-8472	69	13	conducted	conduct	VERB
easat-8472	69	14	this	this	DET
easat-8472	69	15	observational	observational	ADJ
easat-8472	69	16	study	study	NOUN
easat-8472	69	17	.	.	PUNCT
easat-8472	70	1	we	we	PRON
easat-8472	70	2	collected	collect	VERB
easat-8472	70	3	data	datum	NOUN
easat-8472	70	4	from	from	ADP
easat-8472	70	5	january	january	PROPN
easat-8472	70	6	2023	2023	NUM
easat-8472	70	7	to	to	ADP
easat-8472	70	8	2025	2025	NUM
easat-8472	70	9	.	.	PUNCT
easat-8472	71	1	the	the	DET
easat-8472	71	2	inclusion	inclusion	NOUN
easat-8472	71	3	criteria	criterion	NOUN
easat-8472	71	4	are	be	AUX
easat-8472	71	5	both	both	PRON
easat-8472	71	6	resected	resect	VERB
easat-8472	71	7	adenocarsinoma	adenocarsinoma	ADJ
easat-8472	71	8	colon	colon	NOUN
easat-8472	71	9	and	and	CCONJ
easat-8472	71	10	rectum	rectum	NOUN
easat-8472	71	11	and	and	CCONJ
easat-8472	71	12	patients	patient	NOUN
easat-8472	71	13	younger	young	ADJ
easat-8472	71	14	than	than	ADP
easat-8472	71	15	50	50	NUM
easat-8472	71	16	years	year	NOUN
easat-8472	71	17	old	old	ADJ
easat-8472	71	18	who	who	PRON
easat-8472	71	19	progressed	progress	VERB
easat-8472	71	20	to	to	ADP
easat-8472	71	21	bone	bone	NOUN
easat-8472	71	22	metastasis	metastasis	NOUN
easat-8472	71	23	after	after	ADP
easat-8472	71	24	curative	curative	ADJ
easat-8472	71	25	resection	resection	NOUN
easat-8472	71	26	and	and	CCONJ
easat-8472	71	27	adjuvant	adjuvant	ADJ
easat-8472	71	28	treatment	treatment	NOUN
easat-8472	71	29	.	.	PUNCT
easat-8472	72	1	this	this	DET
easat-8472	72	2	study	study	NOUN
easat-8472	72	3	will	will	AUX
easat-8472	72	4	exclude	exclude	VERB
easat-8472	72	5	cases	case	NOUN
easat-8472	72	6	with	with	ADP
easat-8472	72	7	a	a	DET
easat-8472	72	8	history	history	NOUN
easat-8472	72	9	of	of	ADP
easat-8472	72	10	neoadjuvant	neoadjuvant	ADJ
easat-8472	72	11	chemotherapy	chemotherapy	NOUN
easat-8472	72	12	.	.	PUNCT
easat-8472	73	1	patients	patient	NOUN
easat-8472	73	2	with	with	ADP
easat-8472	73	3	adenocarsinoma	adenocarsinoma	ADJ
easat-8472	73	4	colon	colon	NOUN
easat-8472	73	5	and	and	CCONJ
easat-8472	73	6	rectum	rectum	NOUN
easat-8472	73	7	already	already	ADV
easat-8472	73	8	diagnosed	diagnose	VERB
easat-8472	73	9	with	with	ADP
easat-8472	73	10	bone	bone	NOUN
easat-8472	73	11	metastasis	metastasis	NOUN
easat-8472	73	12	from	from	ADP
easat-8472	73	13	the	the	DET
easat-8472	73	14	clinical	clinical	ADJ
easat-8472	73	15	symptom	symptom	NOUN
easat-8472	73	16	of	of	ADP
easat-8472	73	17	pain	pain	NOUN
easat-8472	73	18	and	and	CCONJ
easat-8472	73	19	already	already	ADV
easat-8472	73	20	confirmed	confirm	VERB
easat-8472	73	21	by	by	ADP
easat-8472	73	22	a	a	DET
easat-8472	73	23	bone	bone	NOUN
easat-8472	73	24	survey	survey	NOUN
easat-8472	73	25	exam	exam	NOUN
easat-8472	73	26	will	will	AUX
easat-8472	73	27	be	be	AUX
easat-8472	73	28	recorded	record	VERB
easat-8472	73	29	and	and	CCONJ
easat-8472	73	30	categorised	categorise	VERB
easat-8472	73	31	based	base	VERB
easat-8472	73	32	on	on	ADP
easat-8472	73	33	the	the	DET
easat-8472	73	34	visual	visual	ADJ
easat-8472	73	35	analogue	analogue	NOUN
easat-8472	73	36	score	score	NOUN
easat-8472	73	37	(	(	PUNCT
easat-8472	73	38	vas	vas	NOUN
easat-8472	73	39	)	)	PUNCT
easat-8472	73	40	pain	pain	NOUN
easat-8472	73	41	scoring	scoring	NOUN
easat-8472	73	42	system	system	NOUN
easat-8472	73	43	.	.	PUNCT
easat-8472	74	1	2776	2776	NUM
easat-8472	74	2	edelweiss	edelweiss	PROPN
easat-8472	74	3	applied	apply	VERB
easat-8472	74	4	science	science	NOUN
easat-8472	74	5	and	and	CCONJ
easat-8472	74	6	technology	technology	NOUN
easat-8472	74	7	issn	issn	PROPN
easat-8472	74	8	:	:	PUNCT
easat-8472	74	9	2576	2576	NUM
easat-8472	74	10	-	-	SYM
easat-8472	74	11	8484	8484	NUM
easat-8472	74	12	vol	vol	NOUN
easat-8472	74	13	.	.	PROPN
easat-8472	75	1	9	9	NUM
easat-8472	75	2	,	,	PUNCT
easat-8472	75	3	no	no	INTJ
easat-8472	75	4	.	.	NOUN
easat-8472	76	1	6	6	NUM
easat-8472	76	2	:	:	SYM
easat-8472	76	3	2774	2774	NUM
easat-8472	76	4	-	-	SYM
easat-8472	76	5	2778	2778	NUM
easat-8472	76	6	,	,	PUNCT
easat-8472	76	7	2025	2025	NUM
easat-8472	76	8	doi	doi	NOUN
easat-8472	76	9	:	:	PUNCT
easat-8472	76	10	10.55214/25768484.v9i6.8472	10.55214/25768484.v9i6.8472	NUM
easat-8472	76	11	©	©	PROPN
easat-8472	76	12	2025	2025	NUM
easat-8472	76	13	by	by	ADP
easat-8472	76	14	the	the	DET
easat-8472	76	15	authors	author	NOUN
easat-8472	76	16	;	;	PUNCT
easat-8472	76	17	licensee	licensee	PROPN
easat-8472	76	18	learning	learning	NOUN
easat-8472	76	19	gate	gate	NOUN
easat-8472	76	20	both	both	DET
easat-8472	76	21	patients	patient	NOUN
easat-8472	76	22	were	be	AUX
easat-8472	76	23	included	include	VERB
easat-8472	76	24	in	in	ADP
easat-8472	76	25	this	this	DET
easat-8472	76	26	study	study	NOUN
easat-8472	76	27	and	and	CCONJ
easat-8472	76	28	treated	treat	VERB
easat-8472	76	29	with	with	ADP
easat-8472	76	30	6	6	NUM
easat-8472	76	31	cycles	cycle	NOUN
easat-8472	76	32	of	of	ADP
easat-8472	76	33	intravenous	intravenous	ADJ
easat-8472	76	34	zoledronic	zoledronic	ADJ
easat-8472	76	35	acid	acid	NOUN
easat-8472	76	36	infusion	infusion	NOUN
easat-8472	76	37	at	at	ADP
easat-8472	76	38	4	4	NUM
easat-8472	76	39	-	-	PUNCT
easat-8472	76	40	week	week	NOUN
easat-8472	76	41	intervals	interval	NOUN
easat-8472	76	42	.	.	PUNCT
easat-8472	77	1	vas	vas	NOUN
easat-8472	77	2	scores	score	NOUN
easat-8472	77	3	of	of	ADP
easat-8472	77	4	each	each	DET
easat-8472	77	5	patient	patient	NOUN
easat-8472	77	6	will	will	AUX
easat-8472	77	7	be	be	AUX
easat-8472	77	8	reported	report	VERB
easat-8472	77	9	and	and	CCONJ
easat-8472	77	10	compared	compare	VERB
easat-8472	77	11	with	with	ADP
easat-8472	77	12	the	the	DET
easat-8472	77	13	posttreatment	posttreatment	NOUN
easat-8472	77	14	after	after	ADP
easat-8472	77	15	finishing	finish	VERB
easat-8472	77	16	the	the	DET
easat-8472	77	17	6	6	NUM
easat-8472	77	18	cycles	cycle	NOUN
easat-8472	77	19	of	of	ADP
easat-8472	77	20	za	za	PROPN
easat-8472	77	21	.	.	PUNCT
easat-8472	78	1	the	the	DET
easat-8472	78	2	clinical	clinical	ADJ
easat-8472	78	3	symptom	symptom	NOUN
easat-8472	78	4	which	which	PRON
easat-8472	78	5	is	be	AUX
easat-8472	78	6	to	to	PART
easat-8472	78	7	be	be	AUX
easat-8472	78	8	evaluated	evaluate	VERB
easat-8472	78	9	is	be	AUX
easat-8472	78	10	the	the	DET
easat-8472	78	11	decreasing	decreasing	NOUN
easat-8472	78	12	of	of	ADP
easat-8472	78	13	the	the	DET
easat-8472	78	14	vas	vas	X
easat-8472	78	15	score	score	NOUN
easat-8472	78	16	after	after	ADP
easat-8472	78	17	the	the	DET
easat-8472	78	18	za	za	PROPN
easat-8472	78	19	treatment	treatment	NOUN
easat-8472	78	20	.	.	PUNCT
easat-8472	79	1	3	3	X
easat-8472	79	2	.	.	X
easat-8472	79	3	results	result	NOUN
easat-8472	79	4	during	during	ADP
easat-8472	79	5	the	the	DET
easat-8472	79	6	course	course	NOUN
easat-8472	79	7	of	of	ADP
easat-8472	79	8	our	our	PRON
easat-8472	79	9	research	research	NOUN
easat-8472	79	10	,	,	PUNCT
easat-8472	79	11	we	we	PRON
easat-8472	79	12	documented	document	VERB
easat-8472	79	13	fifteen	fifteen	NUM
easat-8472	79	14	instances	instance	NOUN
easat-8472	79	15	of	of	ADP
easat-8472	79	16	colorectal	colorectal	ADJ
easat-8472	79	17	cancer	cancer	NOUN
easat-8472	79	18	with	with	ADP
easat-8472	79	19	an	an	DET
easat-8472	79	20	early	early	ADJ
easat-8472	79	21	onset	onset	NOUN
easat-8472	79	22	that	that	PRON
easat-8472	79	23	developed	develop	VERB
easat-8472	79	24	bone	bone	NOUN
easat-8472	79	25	metastasis	metastasis	NOUN
easat-8472	79	26	following	follow	VERB
easat-8472	79	27	resection	resection	NOUN
easat-8472	79	28	and	and	CCONJ
easat-8472	79	29	adjuvant	adjuvant	ADJ
easat-8472	79	30	treatment	treatment	NOUN
easat-8472	79	31	.	.	PUNCT
easat-8472	80	1	it	it	PRON
easat-8472	80	2	has	have	AUX
easat-8472	80	3	been	be	AUX
easat-8472	80	4	reported	report	VERB
easat-8472	80	5	that	that	SCONJ
easat-8472	80	6	there	there	PRON
easat-8472	80	7	have	have	AUX
easat-8472	80	8	been	be	AUX
easat-8472	80	9	seven	seven	NUM
easat-8472	80	10	cases	case	NOUN
easat-8472	80	11	of	of	ADP
easat-8472	80	12	sigmoid	sigmoid	NOUN
easat-8472	80	13	adenocarcinoma	adenocarcinoma	NOUN
easat-8472	80	14	.	.	PUNCT
easat-8472	81	1	there	there	PRON
easat-8472	81	2	are	be	VERB
easat-8472	81	3	two	two	NUM
easat-8472	81	4	other	other	ADJ
easat-8472	81	5	sites	site	NOUN
easat-8472	81	6	,	,	PUNCT
easat-8472	81	7	which	which	PRON
easat-8472	81	8	are	be	AUX
easat-8472	81	9	the	the	DET
easat-8472	81	10	rectum	rectum	NOUN
easat-8472	81	11	and	and	CCONJ
easat-8472	81	12	the	the	DET
easat-8472	81	13	ascending	ascend	VERB
easat-8472	81	14	colon	colon	NOUN
easat-8472	81	15	.	.	PUNCT
easat-8472	82	1	chronic	chronic	ADJ
easat-8472	82	2	and	and	CCONJ
easat-8472	82	3	persistent	persistent	ADJ
easat-8472	82	4	pain	pain	NOUN
easat-8472	82	5	is	be	AUX
easat-8472	82	6	the	the	DET
easat-8472	82	7	most	most	ADV
easat-8472	82	8	typical	typical	ADJ
easat-8472	82	9	symptom	symptom	NOUN
easat-8472	82	10	.	.	PUNCT
easat-8472	83	1	following	follow	VERB
easat-8472	83	2	the	the	DET
easat-8472	83	3	completion	completion	NOUN
easat-8472	83	4	of	of	ADP
easat-8472	83	5	six	six	NUM
easat-8472	83	6	cycles	cycle	NOUN
easat-8472	83	7	of	of	ADP
easat-8472	83	8	treatment	treatment	NOUN
easat-8472	83	9	with	with	ADP
easat-8472	83	10	zoledronic	zoledronic	ADJ
easat-8472	83	11	acid	acid	NOUN
easat-8472	83	12	,	,	PUNCT
easat-8472	83	13	the	the	DET
easat-8472	83	14	vas	vas	NOUN
easat-8472	83	15	was	be	AUX
easat-8472	83	16	found	find	VERB
easat-8472	83	17	to	to	PART
easat-8472	83	18	have	have	AUX
easat-8472	83	19	improved	improve	VERB
easat-8472	83	20	,	,	PUNCT
easat-8472	83	21	and	and	CCONJ
easat-8472	83	22	there	there	PRON
easat-8472	83	23	have	have	AUX
easat-8472	83	24	been	be	AUX
easat-8472	83	25	no	no	DET
easat-8472	83	26	further	further	ADJ
easat-8472	83	27	reports	report	NOUN
easat-8472	83	28	of	of	ADP
easat-8472	83	29	skeletal	skeletal	ADJ
easat-8472	83	30	-	-	PUNCT
easat-8472	83	31	related	relate	VERB
easat-8472	83	32	events	event	NOUN
easat-8472	83	33	becoming	become	VERB
easat-8472	83	34	more	more	ADV
easat-8472	83	35	severe	severe	ADJ
easat-8472	83	36	.	.	PUNCT
easat-8472	84	1	the	the	DET
easat-8472	84	2	average	average	NOUN
easat-8472	84	3	of	of	ADP
easat-8472	84	4	the	the	DET
easat-8472	84	5	vas	vas	X
easat-8472	84	6	scores	score	NOUN
easat-8472	84	7	of	of	ADP
easat-8472	84	8	the	the	DET
easat-8472	84	9	patients	patient	NOUN
easat-8472	84	10	with	with	ADP
easat-8472	84	11	bone	bone	NOUN
easat-8472	84	12	metastasis	metastasis	NOUN
easat-8472	84	13	is	be	AUX
easat-8472	84	14	6	6	NUM
easat-8472	84	15	,	,	PUNCT
easat-8472	84	16	and	and	CCONJ
easat-8472	84	17	those	those	PRON
easat-8472	84	18	who	who	PRON
easat-8472	84	19	were	be	AUX
easat-8472	84	20	previously	previously	ADV
easat-8472	84	21	already	already	ADV
easat-8472	84	22	treated	treat	VERB
easat-8472	84	23	with	with	ADP
easat-8472	84	24	nsaids	nsaid	NOUN
easat-8472	84	25	before	before	ADP
easat-8472	84	26	being	be	AUX
easat-8472	84	27	diagnosed	diagnose	VERB
easat-8472	84	28	had	have	VERB
easat-8472	84	29	4	4	NUM
easat-8472	84	30	mg	mg	NOUN
easat-8472	84	31	of	of	ADP
easat-8472	84	32	intravenous	intravenous	ADJ
easat-8472	84	33	zoledronic	zoledronic	ADJ
easat-8472	84	34	acid	acid	NOUN
easat-8472	84	35	administered	administer	VERB
easat-8472	84	36	at	at	ADP
easat-8472	84	37	4	4	NUM
easat-8472	84	38	-	-	PUNCT
easat-8472	84	39	week	week	NOUN
easat-8472	84	40	intervals	interval	NOUN
easat-8472	84	41	.	.	PUNCT
easat-8472	85	1	during	during	ADP
easat-8472	85	2	the	the	DET
easat-8472	85	3	follow	follow	NOUN
easat-8472	85	4	-	-	PUNCT
easat-8472	85	5	up	up	NOUN
easat-8472	85	6	of	of	ADP
easat-8472	85	7	these	these	DET
easat-8472	85	8	cases	case	NOUN
easat-8472	85	9	,	,	PUNCT
easat-8472	85	10	all	all	PRON
easat-8472	85	11	of	of	ADP
easat-8472	85	12	the	the	DET
easat-8472	85	13	patients	patient	NOUN
easat-8472	85	14	had	have	VERB
easat-8472	85	15	improvement	improvement	NOUN
easat-8472	85	16	of	of	ADP
easat-8472	85	17	the	the	DET
easat-8472	85	18	chronic	chronic	ADJ
easat-8472	85	19	pain	pain	NOUN
easat-8472	85	20	regarding	regard	VERB
easat-8472	85	21	the	the	DET
easat-8472	85	22	decreasing	decreasing	NOUN
easat-8472	85	23	of	of	ADP
easat-8472	85	24	the	the	DET
easat-8472	85	25	vas	vas	X
easat-8472	85	26	score	score	NOUN
easat-8472	85	27	to	to	ADP
easat-8472	85	28	1	1	NUM
easat-8472	85	29	-	-	SYM
easat-8472	85	30	2	2	NUM
easat-8472	85	31	after	after	ADP
easat-8472	85	32	completing	complete	VERB
easat-8472	85	33	the	the	DET
easat-8472	85	34	6	6	NUM
easat-8472	85	35	cycles	cycle	NOUN
easat-8472	85	36	of	of	ADP
easat-8472	85	37	zoledronic	zoledronic	ADJ
easat-8472	85	38	acid	acid	NOUN
easat-8472	85	39	.	.	PUNCT
easat-8472	86	1	no	no	DET
easat-8472	86	2	patients	patient	NOUN
easat-8472	86	3	required	require	VERB
easat-8472	86	4	opioid	opioid	ADJ
easat-8472	86	5	analgesia	analgesia	NOUN
easat-8472	86	6	,	,	PUNCT
easat-8472	86	7	and	and	CCONJ
easat-8472	86	8	no	no	DET
easat-8472	86	9	patient	patient	NOUN
easat-8472	86	10	has	have	AUX
easat-8472	86	11	experienced	experience	VERB
easat-8472	86	12	progressive	progressive	ADJ
easat-8472	86	13	disease	disease	NOUN
easat-8472	86	14	or	or	CCONJ
easat-8472	86	15	skeletal	skeletal	ADJ
easat-8472	86	16	-	-	PUNCT
easat-8472	86	17	related	relate	VERB
easat-8472	86	18	events	event	NOUN
easat-8472	86	19	associated	associate	VERB
easat-8472	86	20	with	with	ADP
easat-8472	86	21	the	the	DET
easat-8472	86	22	bone	bone	NOUN
easat-8472	86	23	metastasis	metastasis	NOUN
easat-8472	86	24	of	of	ADP
easat-8472	86	25	colorectal	colorectal	ADJ
easat-8472	86	26	cancer	cancer	NOUN
easat-8472	86	27	.	.	PUNCT
easat-8472	87	1	even	even	ADV
easat-8472	87	2	in	in	ADP
easat-8472	87	3	the	the	DET
easat-8472	87	4	early	early	ADJ
easat-8472	87	5	onset	onset	NOUN
easat-8472	87	6	of	of	ADP
easat-8472	87	7	the	the	DET
easat-8472	87	8	colorectal	colorectal	ADJ
easat-8472	87	9	cancer	cancer	NOUN
easat-8472	87	10	,	,	PUNCT
easat-8472	87	11	both	both	PRON
easat-8472	87	12	of	of	ADP
easat-8472	87	13	the	the	DET
easat-8472	87	14	patients	patient	NOUN
easat-8472	87	15	could	could	AUX
easat-8472	87	16	tolerate	tolerate	VERB
easat-8472	87	17	well	well	INTJ
easat-8472	87	18	these	these	DET
easat-8472	87	19	treatments	treatment	NOUN
easat-8472	87	20	,	,	PUNCT
easat-8472	87	21	and	and	CCONJ
easat-8472	87	22	there	there	PRON
easat-8472	87	23	were	be	VERB
easat-8472	87	24	no	no	DET
easat-8472	87	25	side	side	NOUN
easat-8472	87	26	effects	effect	NOUN
easat-8472	87	27	to	to	PART
easat-8472	87	28	be	be	AUX
easat-8472	87	29	reported	report	VERB
easat-8472	87	30	.	.	PUNCT
easat-8472	88	1	table	table	NOUN
easat-8472	88	2	1	1	NUM
easat-8472	88	3	.	.	PUNCT
easat-8472	89	1	data	datum	NOUN
easat-8472	89	2	characteristic	characteristic	PROPN
easat-8472	89	3	.	.	PUNCT
easat-8472	90	1	characteristics	characteristic	NOUN
easat-8472	90	2	n	n	PRON
easat-8472	90	3	percentage	percentage	NOUN
easat-8472	90	4	(	(	PUNCT
easat-8472	90	5	%	%	NOUN
easat-8472	90	6	)	)	PUNCT
easat-8472	90	7	sex	sex	NOUN
easat-8472	90	8	male	male	NOUN
easat-8472	90	9	7	7	NUM
easat-8472	90	10	47	47	NUM
easat-8472	90	11	%	%	NOUN
easat-8472	90	12	female	female	ADJ
easat-8472	90	13	8	8	NUM
easat-8472	90	14	53	53	NUM
easat-8472	90	15	%	%	NOUN
easat-8472	90	16	tumor	tumor	NOUN
easat-8472	90	17	location	location	NOUN
easat-8472	90	18	ascending	ascend	VERB
easat-8472	90	19	1	1	NUM
easat-8472	90	20	7	7	NUM
easat-8472	90	21	%	%	NOUN
easat-8472	90	22	transverse	transverse	NOUN
easat-8472	90	23	1	1	NUM
easat-8472	90	24	7	7	NUM
easat-8472	90	25	%	%	NOUN
easat-8472	90	26	descendens	descenden	NOUN
easat-8472	90	27	1	1	NUM
easat-8472	90	28	7	7	NUM
easat-8472	90	29	%	%	NOUN
easat-8472	90	30	sigmoid	sigmoid	NOUN
easat-8472	90	31	7	7	NUM
easat-8472	90	32	47	47	NUM
easat-8472	90	33	%	%	NOUN
easat-8472	90	34	rectum	rectum	NOUN
easat-8472	90	35	5	5	NUM
easat-8472	90	36	33	33	NUM
easat-8472	90	37	%	%	NOUN
easat-8472	90	38	vas	vas	NOUN
easat-8472	90	39	score	score	NOUN
easat-8472	90	40	(	(	PUNCT
easat-8472	90	41	mean	mean	NOUN
easat-8472	90	42	)	)	PUNCT
easat-8472	90	43	p	p	NOUN
easat-8472	90	44	value	value	NOUN
easat-8472	90	45	vas	vas	X
easat-8472	90	46	pre	pre	X
easat-8472	90	47	6	6	NUM
easat-8472	90	48	0.000a	0.000a	ADV
easat-8472	90	49	vas	vas	X
easat-8472	90	50	post	post	NOUN
easat-8472	90	51	2	2	NUM
easat-8472	90	52	note	note	NOUN
easat-8472	90	53	:	:	PUNCT
easat-8472	90	54	apaired	apaire	VERB
easat-8472	90	55	t	t	NOUN
easat-8472	90	56	-	-	PUNCT
easat-8472	90	57	test	test	NOUN
easat-8472	90	58	.	.	PUNCT
easat-8472	91	1	4	4	X
easat-8472	91	2	.	.	X
easat-8472	91	3	discussion	discussion	PROPN
easat-8472	91	4	li	li	PROPN
easat-8472	91	5	,	,	PUNCT
easat-8472	91	6	et	et	PROPN
easat-8472	91	7	al	al	PROPN
easat-8472	91	8	.	.	PUNCT
easat-8472	92	1	[	[	X
easat-8472	92	2	6	6	NUM
easat-8472	92	3	]	]	PUNCT
easat-8472	92	4	and	and	CCONJ
easat-8472	92	5	ma	ma	PROPN
easat-8472	92	6	,	,	PUNCT
easat-8472	92	7	et	et	PROPN
easat-8472	92	8	al	al	PROPN
easat-8472	92	9	.	.	PUNCT
easat-8472	93	1	[	[	X
easat-8472	93	2	8	8	NUM
easat-8472	93	3	]	]	X
easat-8472	93	4	state	state	NOUN
easat-8472	93	5	that	that	SCONJ
easat-8472	93	6	metastatic	metastatic	ADJ
easat-8472	93	7	bone	bone	NOUN
easat-8472	93	8	lesions	lesion	NOUN
easat-8472	93	9	are	be	AUX
easat-8472	93	10	classified	classify	VERB
easat-8472	93	11	into	into	ADP
easat-8472	93	12	three	three	NUM
easat-8472	93	13	categories	category	NOUN
easat-8472	93	14	:	:	PUNCT
easat-8472	93	15	osteolytic	osteolytic	ADJ
easat-8472	93	16	,	,	PUNCT
easat-8472	93	17	osteoblastic	osteoblastic	ADJ
easat-8472	93	18	,	,	PUNCT
easat-8472	93	19	and	and	CCONJ
easat-8472	93	20	mixed	mixed	ADJ
easat-8472	93	21	.	.	PUNCT
easat-8472	94	1	osteolytic	osteolytic	ADJ
easat-8472	94	2	lesions	lesion	NOUN
easat-8472	94	3	are	be	AUX
easat-8472	94	4	predominantly	predominantly	ADV
easat-8472	94	5	observed	observe	VERB
easat-8472	94	6	in	in	ADP
easat-8472	94	7	cases	case	NOUN
easat-8472	94	8	of	of	ADP
easat-8472	94	9	crc	crc	NOUN
easat-8472	94	10	.	.	PUNCT
easat-8472	95	1	osteoclasts	osteoclast	NOUN
easat-8472	95	2	are	be	AUX
easat-8472	95	3	responsible	responsible	ADJ
easat-8472	95	4	for	for	ADP
easat-8472	95	5	the	the	DET
easat-8472	95	6	formation	formation	NOUN
easat-8472	95	7	of	of	ADP
easat-8472	95	8	these	these	DET
easat-8472	95	9	lesions	lesion	NOUN
easat-8472	95	10	.	.	PUNCT
easat-8472	96	1	the	the	DET
easat-8472	96	2	process	process	NOUN
easat-8472	96	3	of	of	ADP
easat-8472	96	4	osteoclastogenesis	osteoclastogenesis	NOUN
easat-8472	96	5	,	,	PUNCT
easat-8472	96	6	characterised	characterise	VERB
easat-8472	96	7	by	by	ADP
easat-8472	96	8	an	an	DET
easat-8472	96	9	increase	increase	NOUN
easat-8472	96	10	in	in	ADP
easat-8472	96	11	osteoclasts	osteoclast	NOUN
easat-8472	96	12	and	and	CCONJ
easat-8472	96	13	progenitor	progenitor	NOUN
easat-8472	96	14	osteoclast	osteoclast	ADJ
easat-8472	96	15	cells	cell	NOUN
easat-8472	96	16	,	,	PUNCT
easat-8472	96	17	exacerbates	exacerbate	VERB
easat-8472	96	18	bone	bone	NOUN
easat-8472	96	19	resorption	resorption	NOUN
easat-8472	96	20	.	.	PUNCT
easat-8472	97	1	crc	crc	NOUN
easat-8472	97	2	cells	cell	NOUN
easat-8472	97	3	disseminate	disseminate	VERB
easat-8472	97	4	to	to	ADP
easat-8472	97	5	bone	bone	NOUN
easat-8472	97	6	tissue	tissue	NOUN
easat-8472	97	7	through	through	ADP
easat-8472	97	8	the	the	DET
easat-8472	97	9	expression	expression	NOUN
easat-8472	97	10	of	of	ADP
easat-8472	97	11	ccl3	ccl3	PROPN
easat-8472	97	12	,	,	PUNCT
easat-8472	97	13	a	a	DET
easat-8472	97	14	chemokine	chemokine	NOUN
easat-8472	97	15	that	that	PRON
easat-8472	97	16	directly	directly	ADV
easat-8472	97	17	promotes	promote	VERB
easat-8472	97	18	osteoclastogenesis	osteoclastogenesis	NOUN
easat-8472	97	19	,	,	PUNCT
easat-8472	97	20	thereby	thereby	ADV
easat-8472	97	21	facilitating	facilitate	VERB
easat-8472	97	22	the	the	DET
easat-8472	97	23	progression	progression	NOUN
easat-8472	97	24	of	of	ADP
easat-8472	97	25	the	the	DET
easat-8472	97	26	malignancy	malignancy	NOUN
easat-8472	97	27	,	,	PUNCT
easat-8472	97	28	as	as	SCONJ
easat-8472	97	29	indicated	indicate	VERB
easat-8472	97	30	by	by	ADP
easat-8472	97	31	li	li	PROPN
easat-8472	97	32	,	,	PUNCT
easat-8472	97	33	et	et	PROPN
easat-8472	97	34	al	al	PROPN
easat-8472	97	35	.	.	PUNCT
easat-8472	98	1	[	[	X
easat-8472	98	2	6	6	NUM
easat-8472	98	3	]	]	PUNCT
easat-8472	98	4	and	and	CCONJ
easat-8472	98	5	ma	ma	PROPN
easat-8472	98	6	,	,	PUNCT
easat-8472	98	7	et	et	PROPN
easat-8472	98	8	al	al	PROPN
easat-8472	98	9	.	.	PUNCT
easat-8472	99	1	[	[	X
easat-8472	99	2	8	8	NUM
easat-8472	99	3	]	]	PUNCT
easat-8472	99	4	.	.	PUNCT
easat-8472	100	1	as	as	ADP
easat-8472	100	2	state	state	NOUN
easat-8472	100	3	by	by	ADP
easat-8472	100	4	li	li	PROPN
easat-8472	100	5	,	,	PUNCT
easat-8472	100	6	et	et	PROPN
easat-8472	100	7	al	al	PROPN
easat-8472	100	8	.	.	PUNCT
easat-8472	101	1	[	[	X
easat-8472	101	2	9	9	NUM
easat-8472	101	3	]	]	X
easat-8472	101	4	skeletal	skeletal	ADJ
easat-8472	101	5	-	-	PUNCT
easat-8472	101	6	related	relate	VERB
easat-8472	101	7	events	event	NOUN
easat-8472	101	8	(	(	PUNCT
easat-8472	101	9	sres	sre	NOUN
easat-8472	101	10	)	)	PUNCT
easat-8472	101	11	are	be	AUX
easat-8472	101	12	primarily	primarily	ADV
easat-8472	101	13	associated	associate	VERB
easat-8472	101	14	with	with	ADP
easat-8472	101	15	a	a	DET
easat-8472	101	16	patient	patient	NOUN
easat-8472	101	17	's	's	PART
easat-8472	101	18	morbidity	morbidity	NOUN
easat-8472	101	19	.	.	PUNCT
easat-8472	102	1	bone	bone	NOUN
easat-8472	102	2	metastasis	metastasis	NOUN
easat-8472	102	3	of	of	ADP
easat-8472	102	4	colorectal	colorectal	ADJ
easat-8472	102	5	cancer	cancer	NOUN
easat-8472	102	6	(	(	PUNCT
easat-8472	102	7	crc	crc	NOUN
easat-8472	102	8	)	)	PUNCT
easat-8472	102	9	frequently	frequently	ADV
easat-8472	102	10	manifests	manifest	VERB
easat-8472	102	11	as	as	ADP
easat-8472	102	12	spinal	spinal	ADJ
easat-8472	102	13	cord	cord	NOUN
easat-8472	102	14	compression	compression	NOUN
easat-8472	102	15	,	,	PUNCT
easat-8472	102	16	bone	bone	NOUN
easat-8472	102	17	pain	pain	NOUN
easat-8472	102	18	,	,	PUNCT
easat-8472	102	19	pathologic	pathologic	ADJ
easat-8472	102	20	fractures	fracture	NOUN
easat-8472	102	21	,	,	PUNCT
easat-8472	102	22	and	and	CCONJ
easat-8472	102	23	hypercalcemia	hypercalcemia	NOUN
easat-8472	102	24	.	.	PUNCT
easat-8472	103	1	the	the	DET
easat-8472	103	2	events	event	NOUN
easat-8472	103	3	are	be	AUX
easat-8472	103	4	associated	associate	VERB
easat-8472	103	5	with	with	ADP
easat-8472	103	6	diminished	diminished	ADJ
easat-8472	103	7	quality	quality	NOUN
easat-8472	103	8	of	of	ADP
easat-8472	103	9	life	life	NOUN
easat-8472	103	10	,	,	PUNCT
easat-8472	103	11	increased	increase	VERB
easat-8472	103	12	need	need	NOUN
easat-8472	103	13	for	for	ADP
easat-8472	103	14	supportive	supportive	ADJ
easat-8472	103	15	care	care	NOUN
easat-8472	103	16	,	,	PUNCT
easat-8472	103	17	reduced	reduce	VERB
easat-8472	103	18	survival	survival	NOUN
easat-8472	103	19	rates	rate	NOUN
easat-8472	103	20	,	,	PUNCT
easat-8472	103	21	and	and	CCONJ
easat-8472	103	22	discontinuation	discontinuation	NOUN
easat-8472	103	23	of	of	ADP
easat-8472	103	24	systemic	systemic	ADJ
easat-8472	103	25	2777	2777	NUM
easat-8472	103	26	edelweiss	edelweiss	PROPN
easat-8472	103	27	applied	apply	VERB
easat-8472	103	28	science	science	NOUN
easat-8472	103	29	and	and	CCONJ
easat-8472	103	30	technology	technology	NOUN
easat-8472	103	31	issn	issn	PROPN
easat-8472	103	32	:	:	PUNCT
easat-8472	103	33	2576	2576	NUM
easat-8472	103	34	-	-	SYM
easat-8472	103	35	8484	8484	NUM
easat-8472	103	36	vol	vol	NOUN
easat-8472	103	37	.	.	PROPN
easat-8472	104	1	9	9	NUM
easat-8472	104	2	,	,	PUNCT
easat-8472	104	3	no	no	INTJ
easat-8472	104	4	.	.	NOUN
easat-8472	105	1	6	6	NUM
easat-8472	105	2	:	:	SYM
easat-8472	105	3	2774	2774	NUM
easat-8472	105	4	-	-	SYM
easat-8472	105	5	2778	2778	NUM
easat-8472	105	6	,	,	PUNCT
easat-8472	105	7	2025	2025	NUM
easat-8472	105	8	doi	doi	NOUN
easat-8472	105	9	:	:	PUNCT
easat-8472	105	10	10.55214/25768484.v9i6.8472	10.55214/25768484.v9i6.8472	NUM
easat-8472	105	11	©	©	PROPN
easat-8472	105	12	2025	2025	NUM
easat-8472	105	13	by	by	ADP
easat-8472	105	14	the	the	DET
easat-8472	105	15	authors	author	NOUN
easat-8472	105	16	;	;	PUNCT
easat-8472	105	17	licensee	licensee	PROPN
easat-8472	105	18	learning	learn	VERB
easat-8472	105	19	gate	gate	PROPN
easat-8472	105	20	chemotherapy	chemotherapy	PROPN
easat-8472	105	21	.	.	PUNCT
easat-8472	106	1	bone	bone	NOUN
easat-8472	106	2	tumours	tumours	PROPN
easat-8472	106	3	can	can	AUX
easat-8472	106	4	influence	influence	VERB
easat-8472	106	5	the	the	DET
easat-8472	106	6	surrounding	surround	VERB
easat-8472	106	7	environment	environment	NOUN
easat-8472	106	8	,	,	PUNCT
easat-8472	106	9	leading	lead	VERB
easat-8472	106	10	to	to	ADP
easat-8472	106	11	heightened	heighten	VERB
easat-8472	106	12	sensitivity	sensitivity	NOUN
easat-8472	106	13	of	of	ADP
easat-8472	106	14	nearby	nearby	ADJ
easat-8472	106	15	nerves	nerve	NOUN
easat-8472	106	16	and	and	CCONJ
easat-8472	106	17	resulting	result	VERB
easat-8472	106	18	in	in	ADP
easat-8472	106	19	significant	significant	ADJ
easat-8472	106	20	pain	pain	NOUN
easat-8472	106	21	.	.	PUNCT
easat-8472	107	1	pain	pain	NOUN
easat-8472	107	2	is	be	AUX
easat-8472	107	3	often	often	ADV
easat-8472	107	4	the	the	DET
easat-8472	107	5	initial	initial	ADJ
easat-8472	107	6	symptom	symptom	NOUN
easat-8472	107	7	that	that	PRON
easat-8472	107	8	indicates	indicate	VERB
easat-8472	107	9	the	the	DET
easat-8472	107	10	presence	presence	NOUN
easat-8472	107	11	of	of	ADP
easat-8472	107	12	bone	bone	NOUN
easat-8472	107	13	metastasis	metastasis	NOUN
easat-8472	107	14	.	.	PUNCT
easat-8472	108	1	there	there	PRON
easat-8472	108	2	is	be	VERB
easat-8472	108	3	a	a	DET
easat-8472	108	4	concern	concern	NOUN
easat-8472	108	5	that	that	SCONJ
easat-8472	108	6	the	the	DET
easat-8472	108	7	rise	rise	NOUN
easat-8472	108	8	in	in	ADP
easat-8472	108	9	colorectal	colorectal	ADJ
easat-8472	108	10	cancer	cancer	NOUN
easat-8472	108	11	survivability	survivability	NOUN
easat-8472	108	12	may	may	AUX
easat-8472	108	13	lead	lead	VERB
easat-8472	108	14	to	to	ADP
easat-8472	108	15	an	an	DET
easat-8472	108	16	increase	increase	NOUN
easat-8472	108	17	in	in	ADP
easat-8472	108	18	the	the	DET
easat-8472	108	19	incidence	incidence	NOUN
easat-8472	108	20	of	of	ADP
easat-8472	108	21	bone	bone	NOUN
easat-8472	108	22	metastasis	metastasis	NOUN
easat-8472	108	23	associated	associate	VERB
easat-8472	108	24	with	with	ADP
easat-8472	108	25	this	this	DET
easat-8472	108	26	disease	disease	NOUN
easat-8472	108	27	.	.	PUNCT
easat-8472	109	1	treatment	treatment	NOUN
easat-8472	109	2	strategies	strategy	NOUN
easat-8472	109	3	for	for	ADP
easat-8472	109	4	patients	patient	NOUN
easat-8472	109	5	with	with	ADP
easat-8472	109	6	colorectal	colorectal	ADJ
easat-8472	109	7	cancer	cancer	NOUN
easat-8472	109	8	bone	bone	NOUN
easat-8472	109	9	metastasis	metastasis	NOUN
easat-8472	109	10	focus	focus	VERB
easat-8472	109	11	on	on	ADP
easat-8472	109	12	systemic	systemic	ADJ
easat-8472	109	13	or	or	CCONJ
easat-8472	109	14	local	local	ADJ
easat-8472	109	15	control	control	NOUN
easat-8472	109	16	methods	method	NOUN
easat-8472	109	17	.	.	PUNCT
easat-8472	110	1	systemic	systemic	ADJ
easat-8472	110	2	treatment	treatment	NOUN
easat-8472	110	3	seeks	seek	VERB
easat-8472	110	4	to	to	PART
easat-8472	110	5	manage	manage	VERB
easat-8472	110	6	the	the	DET
easat-8472	110	7	advancement	advancement	NOUN
easat-8472	110	8	of	of	ADP
easat-8472	110	9	metastasis	metastasis	NOUN
easat-8472	110	10	and	and	CCONJ
easat-8472	110	11	diminish	diminish	VERB
easat-8472	110	12	skeletal	skeletal	ADJ
easat-8472	110	13	-	-	PUNCT
easat-8472	110	14	related	relate	VERB
easat-8472	110	15	events	event	NOUN
easat-8472	110	16	(	(	PUNCT
easat-8472	110	17	sres	sre	NOUN
easat-8472	110	18	)	)	PUNCT
easat-8472	110	19	.	.	PUNCT
easat-8472	111	1	localised	localise	VERB
easat-8472	111	2	treatment	treatment	NOUN
easat-8472	111	3	seeks	seek	VERB
easat-8472	111	4	to	to	PART
easat-8472	111	5	enhance	enhance	VERB
easat-8472	111	6	localised	localised	ADJ
easat-8472	111	7	lesions	lesion	NOUN
easat-8472	111	8	in	in	ADP
easat-8472	111	9	patients	patient	NOUN
easat-8472	111	10	with	with	ADP
easat-8472	111	11	a	a	DET
easat-8472	111	12	minimum	minimum	ADJ
easat-8472	111	13	life	life	NOUN
easat-8472	111	14	expectancy	expectancy	NOUN
easat-8472	111	15	of	of	ADP
easat-8472	111	16	six	six	NUM
easat-8472	111	17	weeks	week	NOUN
easat-8472	111	18	,	,	PUNCT
easat-8472	111	19	emphasising	emphasise	VERB
easat-8472	111	20	the	the	DET
easat-8472	111	21	stabilisation	stabilisation	NOUN
easat-8472	111	22	of	of	ADP
easat-8472	111	23	bone	bone	NOUN
easat-8472	111	24	.	.	PUNCT
easat-8472	112	1	treatment	treatment	NOUN
easat-8472	112	2	methods	method	NOUN
easat-8472	112	3	must	must	AUX
easat-8472	112	4	take	take	VERB
easat-8472	112	5	into	into	ADP
easat-8472	112	6	account	account	NOUN
easat-8472	112	7	a	a	DET
easat-8472	112	8	patient	patient	NOUN
easat-8472	112	9	's	's	PART
easat-8472	112	10	prognosis	prognosis	NOUN
easat-8472	112	11	,	,	PUNCT
easat-8472	112	12	pain	pain	NOUN
easat-8472	112	13	management	management	NOUN
easat-8472	112	14	capabilities	capability	NOUN
easat-8472	112	15	,	,	PUNCT
easat-8472	112	16	life	life	NOUN
easat-8472	112	17	expectancy	expectancy	NOUN
easat-8472	112	18	,	,	PUNCT
easat-8472	112	19	tumour	tumour	NOUN
easat-8472	112	20	staging	staging	NOUN
easat-8472	112	21	,	,	PUNCT
easat-8472	112	22	and	and	CCONJ
easat-8472	112	23	localisation	localisation	NOUN
easat-8472	112	24	,	,	PUNCT
easat-8472	112	25	among	among	ADP
easat-8472	112	26	other	other	ADJ
easat-8472	112	27	factors	factor	NOUN
easat-8472	112	28	.	.	PUNCT
easat-8472	113	1	individuals	individual	NOUN
easat-8472	113	2	with	with	ADP
easat-8472	113	3	colorectal	colorectal	ADJ
easat-8472	113	4	cancer	cancer	NOUN
easat-8472	113	5	metastasising	metastasising	NOUN
easat-8472	113	6	to	to	ADP
easat-8472	113	7	the	the	DET
easat-8472	113	8	bone	bone	NOUN
easat-8472	113	9	exhibit	exhibit	VERB
easat-8472	113	10	an	an	DET
easat-8472	113	11	increased	increased	ADJ
easat-8472	113	12	risk	risk	NOUN
easat-8472	113	13	of	of	ADP
easat-8472	113	14	skeletalrelated	skeletalrelate	VERB
easat-8472	113	15	events	event	NOUN
easat-8472	113	16	(	(	PUNCT
easat-8472	113	17	sres	sre	NOUN
easat-8472	113	18	)	)	PUNCT
easat-8472	113	19	as	as	SCONJ
easat-8472	113	20	indicated	indicate	VERB
easat-8472	113	21	by	by	ADP
easat-8472	113	22	baek	baek	NOUN
easat-8472	113	23	,	,	PUNCT
easat-8472	113	24	et	et	PROPN
easat-8472	113	25	al	al	PROPN
easat-8472	113	26	.	.	PUNCT
easat-8472	114	1	[	[	X
easat-8472	114	2	10	10	NUM
easat-8472	114	3	]	]	PUNCT
easat-8472	114	4	.	.	PUNCT
easat-8472	115	1	as	as	ADP
easat-8472	115	2	state	state	NOUN
easat-8472	115	3	by	by	ADP
easat-8472	115	4	kawamura	kawamura	PROPN
easat-8472	115	5	,	,	PUNCT
easat-8472	115	6	et	et	PROPN
easat-8472	115	7	al	al	PROPN
easat-8472	115	8	.	.	PUNCT
easat-8472	116	1	[	[	X
easat-8472	116	2	7	7	X
easat-8472	116	3	]	]	PUNCT
easat-8472	116	4	and	and	CCONJ
easat-8472	116	5	liu	liu	PROPN
easat-8472	116	6	,	,	PUNCT
easat-8472	116	7	et	et	PROPN
easat-8472	116	8	al	al	PROPN
easat-8472	116	9	.	.	PUNCT
easat-8472	117	1	[	[	X
easat-8472	117	2	11	11	NUM
easat-8472	117	3	]	]	PUNCT
easat-8472	117	4	.	.	PUNCT
easat-8472	118	1	patients	patient	NOUN
easat-8472	118	2	may	may	AUX
easat-8472	118	3	exhibit	exhibit	VERB
easat-8472	118	4	compromised	compromise	VERB
easat-8472	118	5	bone	bone	NOUN
easat-8472	118	6	integrity	integrity	NOUN
easat-8472	118	7	,	,	PUNCT
easat-8472	118	8	resulting	result	VERB
easat-8472	118	9	in	in	ADP
easat-8472	118	10	spinal	spinal	ADJ
easat-8472	118	11	cord	cord	NOUN
easat-8472	118	12	compression	compression	NOUN
easat-8472	118	13	and	and	CCONJ
easat-8472	118	14	pathological	pathological	ADJ
easat-8472	118	15	fractures	fracture	NOUN
easat-8472	118	16	.	.	PUNCT
easat-8472	119	1	the	the	DET
easat-8472	119	2	process	process	NOUN
easat-8472	119	3	of	of	ADP
easat-8472	119	4	bone	bone	NOUN
easat-8472	119	5	resorption	resorption	NOUN
easat-8472	119	6	releases	release	VERB
easat-8472	119	7	calcium	calcium	NOUN
easat-8472	119	8	into	into	ADP
easat-8472	119	9	the	the	DET
easat-8472	119	10	bloodstream	bloodstream	NOUN
easat-8472	119	11	,	,	PUNCT
easat-8472	119	12	which	which	PRON
easat-8472	119	13	may	may	AUX
easat-8472	119	14	result	result	VERB
easat-8472	119	15	in	in	ADP
easat-8472	119	16	hypercalcemia	hypercalcemia	NOUN
easat-8472	119	17	associated	associate	VERB
easat-8472	119	18	with	with	ADP
easat-8472	119	19	malignancy	malignancy	NOUN
easat-8472	119	20	.	.	PUNCT
easat-8472	120	1	the	the	DET
easat-8472	120	2	results	result	NOUN
easat-8472	120	3	support	support	VERB
easat-8472	120	4	the	the	DET
easat-8472	120	5	application	application	NOUN
easat-8472	120	6	of	of	ADP
easat-8472	120	7	pharmacological	pharmacological	ADJ
easat-8472	120	8	interventions	intervention	NOUN
easat-8472	120	9	to	to	PART
easat-8472	120	10	suppress	suppress	VERB
easat-8472	120	11	osteoclast	osteoclast	ADJ
easat-8472	120	12	activity	activity	NOUN
easat-8472	120	13	,	,	PUNCT
easat-8472	120	14	including	include	VERB
easat-8472	120	15	bisphosphonates	bisphosphonate	NOUN
easat-8472	120	16	(	(	PUNCT
easat-8472	120	17	bps	bps	NOUN
easat-8472	120	18	)	)	PUNCT
easat-8472	120	19	and	and	CCONJ
easat-8472	120	20	denosumab	denosumab	NOUN
easat-8472	120	21	.	.	PUNCT
easat-8472	121	1	bisphosphonates	bisphosphonate	NOUN
easat-8472	121	2	inhibit	inhibit	VERB
easat-8472	121	3	farnesyl	farnesyl	ADJ
easat-8472	121	4	pyrophosphate	pyrophosphate	NOUN
easat-8472	121	5	synthase	synthase	NOUN
easat-8472	121	6	,	,	PUNCT
easat-8472	121	7	thereby	thereby	ADV
easat-8472	121	8	suppressing	suppress	VERB
easat-8472	121	9	osteoclast	osteoclast	ADJ
easat-8472	121	10	proliferation	proliferation	NOUN
easat-8472	121	11	and	and	CCONJ
easat-8472	121	12	promoting	promote	VERB
easat-8472	121	13	their	their	PRON
easat-8472	121	14	apoptosis	apoptosis	NOUN
easat-8472	121	15	.	.	PUNCT
easat-8472	122	1	zoledronic	zoledronic	ADJ
easat-8472	122	2	acid	acid	NOUN
easat-8472	122	3	(	(	PUNCT
easat-8472	122	4	za	za	PROPN
easat-8472	122	5	)	)	PUNCT
easat-8472	122	6	is	be	AUX
easat-8472	122	7	a	a	DET
easat-8472	122	8	widely	widely	ADV
easat-8472	122	9	used	use	VERB
easat-8472	122	10	bisphosphonate	bisphosphonate	NOUN
easat-8472	122	11	for	for	ADP
easat-8472	122	12	the	the	DET
easat-8472	122	13	prevention	prevention	NOUN
easat-8472	122	14	of	of	ADP
easat-8472	122	15	skeletal	skeletal	ADJ
easat-8472	122	16	-	-	PUNCT
easat-8472	122	17	related	relate	VERB
easat-8472	122	18	events	event	NOUN
easat-8472	122	19	(	(	PUNCT
easat-8472	122	20	sres	sre	NOUN
easat-8472	122	21	)	)	PUNCT
easat-8472	122	22	and	and	CCONJ
easat-8472	122	23	the	the	DET
easat-8472	122	24	correction	correction	NOUN
easat-8472	122	25	of	of	ADP
easat-8472	122	26	hypercalcemia	hypercalcemia	NOUN
easat-8472	122	27	associated	associate	VERB
easat-8472	122	28	with	with	ADP
easat-8472	122	29	malignancy	malignancy	NOUN
easat-8472	122	30	.	.	PUNCT
easat-8472	123	1	the	the	DET
easat-8472	123	2	systemic	systemic	ADJ
easat-8472	123	3	treatment	treatment	NOUN
easat-8472	123	4	of	of	ADP
easat-8472	123	5	bone	bone	NOUN
easat-8472	123	6	metastases	metastasis	NOUN
easat-8472	123	7	may	may	AUX
easat-8472	123	8	involve	involve	VERB
easat-8472	123	9	the	the	DET
easat-8472	123	10	supplementation	supplementation	NOUN
easat-8472	123	11	of	of	ADP
easat-8472	123	12	vitamin	vitamin	NOUN
easat-8472	123	13	d	d	NOUN
easat-8472	123	14	and	and	CCONJ
easat-8472	123	15	calcium	calcium	NOUN
easat-8472	123	16	to	to	PART
easat-8472	123	17	prevent	prevent	VERB
easat-8472	123	18	drug	drug	NOUN
easat-8472	123	19	-	-	PUNCT
easat-8472	123	20	induced	induce	VERB
easat-8472	123	21	hypocalcaemia	hypocalcaemia	NOUN
easat-8472	123	22	associated	associate	VERB
easat-8472	123	23	with	with	ADP
easat-8472	123	24	bisphosphonates	bisphosphonate	NOUN
easat-8472	123	25	and	and	CCONJ
easat-8472	123	26	denosumab	denosumab	NOUN
easat-8472	123	27	.	.	PUNCT
easat-8472	124	1	dexamethasone	dexamethasone	PROPN
easat-8472	124	2	,	,	PUNCT
easat-8472	124	3	a	a	DET
easat-8472	124	4	glucocorticoid	glucocorticoid	NOUN
easat-8472	124	5	that	that	PRON
easat-8472	124	6	inhibits	inhibit	VERB
easat-8472	124	7	inflammatory	inflammatory	ADJ
easat-8472	124	8	processes	process	NOUN
easat-8472	124	9	,	,	PUNCT
easat-8472	124	10	is	be	AUX
easat-8472	124	11	also	also	ADV
easat-8472	124	12	employed	employ	VERB
easat-8472	124	13	for	for	ADP
easat-8472	124	14	the	the	DET
easat-8472	124	15	prophylaxis	prophylaxis	NOUN
easat-8472	124	16	of	of	ADP
easat-8472	124	17	bone	bone	NOUN
easat-8472	124	18	pain	pain	NOUN
easat-8472	124	19	resulting	result	VERB
easat-8472	124	20	from	from	ADP
easat-8472	124	21	radiation	radiation	NOUN
easat-8472	124	22	exposure	exposure	NOUN
easat-8472	124	23	.	.	PUNCT
easat-8472	125	1	5	5	X
easat-8472	125	2	.	.	X
easat-8472	125	3	conclusion	conclusion	NOUN
easat-8472	125	4	although	although	SCONJ
easat-8472	125	5	it	it	PRON
easat-8472	125	6	might	might	AUX
easat-8472	125	7	be	be	AUX
easat-8472	125	8	to	to	PART
easat-8472	125	9	early	early	ADV
easat-8472	125	10	,	,	PUNCT
easat-8472	125	11	from	from	ADP
easat-8472	125	12	this	this	DET
easat-8472	125	13	observational	observational	ADJ
easat-8472	125	14	study	study	NOUN
easat-8472	125	15	it	it	PRON
easat-8472	125	16	will	will	AUX
easat-8472	125	17	be	be	AUX
easat-8472	125	18	decided	decide	VERB
easat-8472	125	19	that	that	SCONJ
easat-8472	125	20	the	the	DET
easat-8472	125	21	administration	administration	NOUN
easat-8472	125	22	of	of	ADP
easat-8472	125	23	zoledronic	zoledronic	ADJ
easat-8472	125	24	acid	acid	NOUN
easat-8472	125	25	4	4	NUM
easat-8472	125	26	weekly	weekly	NOUN
easat-8472	125	27	for	for	ADP
easat-8472	125	28	another	another	DET
easat-8472	125	29	6	6	NUM
easat-8472	125	30	cycles	cycle	NOUN
easat-8472	125	31	as	as	ADP
easat-8472	125	32	adjuvant	adjuvant	ADJ
easat-8472	125	33	treatment	treatment	NOUN
easat-8472	125	34	could	could	AUX
easat-8472	125	35	prevent	prevent	VERB
easat-8472	125	36	the	the	DET
easat-8472	125	37	future	future	ADJ
easat-8472	125	38	skeletal	skeletal	ADJ
easat-8472	125	39	related	relate	VERB
easat-8472	125	40	events	event	NOUN
easat-8472	125	41	and	and	CCONJ
easat-8472	125	42	these	these	PRON
easat-8472	125	43	the	the	DET
easat-8472	125	44	patients	patient	NOUN
easat-8472	125	45	could	could	AUX
easat-8472	125	46	tolerated	tolerate	VERB
easat-8472	125	47	well	well	ADV
easat-8472	125	48	with	with	ADP
easat-8472	125	49	these	these	DET
easat-8472	125	50	treatment	treatment	NOUN
easat-8472	125	51	.	.	PUNCT
easat-8472	126	1	institutional	institutional	ADJ
easat-8472	126	2	review	review	PROPN
easat-8472	126	3	board	board	NOUN
easat-8472	126	4	statement	statement	NOUN
easat-8472	126	5	:	:	PUNCT
easat-8472	126	6	this	this	DET
easat-8472	126	7	case	case	NOUN
easat-8472	126	8	study	study	NOUN
easat-8472	126	9	has	have	AUX
easat-8472	126	10	already	already	ADV
easat-8472	126	11	been	be	AUX
easat-8472	126	12	approved	approve	VERB
easat-8472	126	13	the	the	DET
easat-8472	126	14	institutional	institutional	ADJ
easat-8472	126	15	review	review	NOUN
easat-8472	126	16	board	board	NOUN
easat-8472	126	17	by	by	ADP
easat-8472	126	18	health	health	PROPN
easat-8472	126	19	research	research	PROPN
easat-8472	126	20	ethic	ethic	PROPN
easat-8472	126	21	committee	committee	NOUN
easat-8472	126	22	of	of	ADP
easat-8472	126	23	moewardi	moewardi	PROPN
easat-8472	126	24	general	general	ADJ
easat-8472	126	25	hospital	hospital	PROPN
easat-8472	126	26	,	,	PUNCT
easat-8472	126	27	surakarta	surakarta	NOUN
easat-8472	126	28	,	,	PUNCT
easat-8472	126	29	indonesia	indonesia	PROPN
easat-8472	126	30	.	.	PUNCT
easat-8472	127	1	funding	funding	PROPN
easat-8472	127	2	:	:	PUNCT
easat-8472	127	3	this	this	DET
easat-8472	127	4	research	research	NOUN
easat-8472	127	5	is	be	AUX
easat-8472	127	6	supported	support	VERB
easat-8472	127	7	by	by	ADP
easat-8472	127	8	sebelas	sebelas	PROPN
easat-8472	127	9	maret	maret	PROPN
easat-8472	127	10	university	university	PROPN
easat-8472	127	11	research	research	NOUN
easat-8472	127	12	grant	grant	NOUN
easat-8472	127	13	2025371	2025371	NUM
easat-8472	127	14	/	/	SYM
easat-8472	127	15	un27.22	un27.22	NOUN
easat-8472	127	16	/	/	SYM
easat-8472	127	17	pt.01.03/2025	pt.01.03/2025	ADJ
easat-8472	127	18	(	(	PUNCT
easat-8472	127	19	grant	grant	NOUN
easat-8472	127	20	number	number	NOUN
easat-8472	127	21	:	:	PUNCT
easat-8472	127	22	371	371	NUM
easat-8472	127	23	/	/	SYM
easat-8472	127	24	un27.22	un27.22	NOUN
easat-8472	127	25	/	/	SYM
easat-8472	127	26	pt.01.03/2025	pt.01.03/2025	ADJ
easat-8472	127	27	)	)	PUNCT
easat-8472	127	28	.	.	PUNCT
easat-8472	128	1	transparency	transparency	NOUN
easat-8472	128	2	:	:	PUNCT
easat-8472	128	3	the	the	DET
easat-8472	128	4	authors	author	NOUN
easat-8472	128	5	confirm	confirm	VERB
easat-8472	128	6	that	that	SCONJ
easat-8472	128	7	the	the	DET
easat-8472	128	8	manuscript	manuscript	NOUN
easat-8472	128	9	is	be	AUX
easat-8472	128	10	an	an	DET
easat-8472	128	11	honest	honest	ADJ
easat-8472	128	12	,	,	PUNCT
easat-8472	128	13	accurate	accurate	ADJ
easat-8472	128	14	,	,	PUNCT
easat-8472	128	15	and	and	CCONJ
easat-8472	128	16	transparent	transparent	ADJ
easat-8472	128	17	account	account	NOUN
easat-8472	128	18	of	of	ADP
easat-8472	128	19	the	the	DET
easat-8472	128	20	study	study	NOUN
easat-8472	128	21	;	;	PUNCT
easat-8472	128	22	that	that	SCONJ
easat-8472	128	23	no	no	DET
easat-8472	128	24	vital	vital	ADJ
easat-8472	128	25	features	feature	NOUN
easat-8472	128	26	of	of	ADP
easat-8472	128	27	the	the	DET
easat-8472	128	28	study	study	NOUN
easat-8472	128	29	have	have	AUX
easat-8472	128	30	been	be	AUX
easat-8472	128	31	omitted	omit	VERB
easat-8472	128	32	;	;	PUNCT
easat-8472	128	33	and	and	CCONJ
easat-8472	128	34	that	that	SCONJ
easat-8472	128	35	any	any	DET
easat-8472	128	36	discrepancies	discrepancy	NOUN
easat-8472	128	37	from	from	ADP
easat-8472	128	38	the	the	DET
easat-8472	128	39	study	study	NOUN
easat-8472	128	40	as	as	SCONJ
easat-8472	128	41	planned	plan	VERB
easat-8472	128	42	have	have	AUX
easat-8472	128	43	been	be	AUX
easat-8472	128	44	explained	explain	VERB
easat-8472	128	45	.	.	PUNCT
easat-8472	129	1	this	this	DET
easat-8472	129	2	study	study	NOUN
easat-8472	129	3	followed	follow	VERB
easat-8472	129	4	all	all	DET
easat-8472	129	5	ethical	ethical	ADJ
easat-8472	129	6	practices	practice	NOUN
easat-8472	129	7	during	during	ADP
easat-8472	129	8	writing	writing	NOUN
easat-8472	129	9	.	.	PUNCT
easat-8472	130	1	acknowledgment	acknowledgment	NOUN
easat-8472	130	2	:	:	PUNCT
easat-8472	131	1	authors	author	NOUN
easat-8472	131	2	would	would	AUX
easat-8472	131	3	like	like	VERB
easat-8472	131	4	to	to	ADP
easat-8472	131	5	thanks	thank	NOUN
easat-8472	131	6	the	the	DET
easat-8472	131	7	sebelas	sebelas	PROPN
easat-8472	131	8	maret	maret	PROPN
easat-8472	131	9	university	university	PROPN
easat-8472	131	10	research	research	NOUN
easat-8472	131	11	unit	unit	NOUN
easat-8472	131	12	which	which	PRON
easat-8472	131	13	already	already	ADV
easat-8472	131	14	supported	support	VERB
easat-8472	131	15	this	this	DET
easat-8472	131	16	study	study	NOUN
easat-8472	131	17	with	with	ADP
easat-8472	131	18	research	research	NOUN
easat-8472	131	19	grant	grant	NOUN
easat-8472	131	20	2025	2025	NUM
easat-8472	131	21	.	.	PUNCT
easat-8472	132	1	2778	2778	NUM
easat-8472	132	2	edelweiss	edelweiss	PROPN
easat-8472	132	3	applied	apply	VERB
easat-8472	132	4	science	science	NOUN
easat-8472	132	5	and	and	CCONJ
easat-8472	132	6	technology	technology	NOUN
easat-8472	132	7	issn	issn	PROPN
easat-8472	132	8	:	:	PUNCT
easat-8472	132	9	2576	2576	NUM
easat-8472	132	10	-	-	SYM
easat-8472	132	11	8484	8484	NUM
easat-8472	132	12	vol	vol	NOUN
easat-8472	132	13	.	.	PROPN
easat-8472	133	1	9	9	NUM
easat-8472	133	2	,	,	PUNCT
easat-8472	133	3	no	no	INTJ
easat-8472	133	4	.	.	NOUN
easat-8472	134	1	6	6	NUM
easat-8472	134	2	:	:	SYM
easat-8472	134	3	2774	2774	NUM
easat-8472	134	4	-	-	SYM
easat-8472	134	5	2778	2778	NUM
easat-8472	134	6	,	,	PUNCT
easat-8472	134	7	2025	2025	NUM
easat-8472	134	8	doi	doi	NOUN
easat-8472	134	9	:	:	PUNCT
easat-8472	134	10	10.55214/25768484.v9i6.8472	10.55214/25768484.v9i6.8472	NUM
easat-8472	134	11	©	©	PROPN
easat-8472	134	12	2025	2025	NUM
easat-8472	134	13	by	by	ADP
easat-8472	134	14	the	the	DET
easat-8472	134	15	authors	author	NOUN
easat-8472	134	16	;	;	PUNCT
easat-8472	135	1	licensee	licensee	PROPN
easat-8472	135	2	learning	learn	VERB
easat-8472	135	3	gate	gate	NOUN
easat-8472	135	4	copyright	copyright	NOUN
easat-8472	135	5	:	:	PUNCT
easat-8472	135	6	©	©	PROPN
easat-8472	135	7	2025	2025	NUM
easat-8472	135	8	by	by	ADP
easat-8472	135	9	the	the	DET
easat-8472	135	10	authors	author	NOUN
easat-8472	135	11	.	.	PUNCT
easat-8472	136	1	this	this	DET
easat-8472	136	2	open	open	ADJ
easat-8472	136	3	-	-	PUNCT
easat-8472	136	4	access	access	NOUN
easat-8472	136	5	article	article	NOUN
easat-8472	136	6	is	be	AUX
easat-8472	136	7	distributed	distribute	VERB
easat-8472	136	8	under	under	ADP
easat-8472	136	9	the	the	DET
easat-8472	136	10	terms	term	NOUN
easat-8472	136	11	and	and	CCONJ
easat-8472	136	12	conditions	condition	NOUN
easat-8472	136	13	of	of	ADP
easat-8472	136	14	the	the	DET
easat-8472	136	15	creative	creative	ADJ
easat-8472	136	16	commons	common	NOUN
easat-8472	136	17	attribution	attribution	NOUN
easat-8472	136	18	(	(	PUNCT
easat-8472	136	19	cc	cc	NOUN
easat-8472	136	20	by	by	ADP
easat-8472	136	21	)	)	PUNCT
easat-8472	136	22	license	license	NOUN
easat-8472	136	23	(	(	PUNCT
easat-8472	136	24	https://creativecommons.org/licenses/by/4.0/	https://creativecommons.org/licenses/by/4.0/	PROPN
easat-8472	136	25	)	)	PUNCT
easat-8472	136	26	.	.	PUNCT
easat-8472	137	1	references	reference	NOUN
easat-8472	137	2	[	[	X
easat-8472	137	3	1	1	X
easat-8472	137	4	]	]	PUNCT
easat-8472	137	5	j.	j.	PROPN
easat-8472	137	6	fornetti	fornetti	PROPN
easat-8472	137	7	,	,	PUNCT
easat-8472	137	8	a.	a.	PROPN
easat-8472	137	9	l.	l.	PROPN
easat-8472	137	10	welm	welm	PROPN
easat-8472	137	11	,	,	PUNCT
easat-8472	137	12	and	and	CCONJ
easat-8472	137	13	s.	s.	PROPN
easat-8472	137	14	a.	a.	PROPN
easat-8472	137	15	stewart	stewart	PROPN
easat-8472	137	16	,	,	PUNCT
easat-8472	137	17	"	"	PUNCT
easat-8472	137	18	understanding	understand	VERB
easat-8472	137	19	the	the	DET
easat-8472	137	20	bone	bone	NOUN
easat-8472	137	21	in	in	ADP
easat-8472	137	22	cancer	cancer	NOUN
easat-8472	137	23	metastasis	metastasis	NOUN
easat-8472	137	24	,	,	PUNCT
easat-8472	137	25	"	"	PUNCT
easat-8472	137	26	journal	journal	NOUN
easat-8472	137	27	of	of	ADP
easat-8472	137	28	bone	bone	NOUN
easat-8472	137	29	and	and	CCONJ
easat-8472	137	30	mineral	mineral	NOUN
easat-8472	137	31	research	research	NOUN
easat-8472	137	32	,	,	PUNCT
easat-8472	137	33	vol	vol	NOUN
easat-8472	137	34	.	.	PROPN
easat-8472	137	35	33	33	NUM
easat-8472	137	36	,	,	PUNCT
easat-8472	137	37	no	no	INTJ
easat-8472	137	38	.	.	NOUN
easat-8472	137	39	12	12	NUM
easat-8472	137	40	,	,	PUNCT
easat-8472	137	41	pp	pp	ADJ
easat-8472	137	42	.	.	PUNCT
easat-8472	137	43	2099	2099	NUM
easat-8472	137	44	-	-	SYM
easat-8472	137	45	2113	2113	NUM
easat-8472	137	46	,	,	PUNCT
easat-8472	137	47	2018	2018	NUM
easat-8472	137	48	.	.	PUNCT
easat-8472	138	1	[	[	X
easat-8472	138	2	2	2	NUM
easat-8472	138	3	]	]	X
easat-8472	138	4	l.	l.	PROPN
easat-8472	138	5	holladay	holladay	PROPN
easat-8472	138	6	,	,	PUNCT
easat-8472	138	7	j.	j.	PROPN
easat-8472	138	8	luu	luu	PROPN
easat-8472	138	9	,	,	PUNCT
easat-8472	138	10	v.	v.	ADP
easat-8472	138	11	balendra	balendra	NOUN
easat-8472	138	12	,	,	PUNCT
easat-8472	138	13	and	and	CCONJ
easat-8472	138	14	k.	k.	PROPN
easat-8472	138	15	kmetz	kmetz	PROPN
easat-8472	138	16	,	,	PUNCT
easat-8472	138	17	"	"	PUNCT
easat-8472	138	18	current	current	ADJ
easat-8472	138	19	and	and	CCONJ
easat-8472	138	20	potential	potential	ADJ
easat-8472	138	21	treatment	treatment	NOUN
easat-8472	138	22	of	of	ADP
easat-8472	138	23	colorectal	colorectal	ADJ
easat-8472	138	24	cancer	cancer	NOUN
easat-8472	138	25	metastasis	metastasis	NOUN
easat-8472	138	26	to	to	ADP
easat-8472	138	27	bone	bone	NOUN
easat-8472	138	28	,	,	PUNCT
easat-8472	138	29	"	"	PUNCT
easat-8472	138	30	cancer	cancer	NOUN
easat-8472	138	31	treatment	treatment	NOUN
easat-8472	138	32	and	and	CCONJ
easat-8472	138	33	research	research	NOUN
easat-8472	138	34	communications	communication	NOUN
easat-8472	138	35	,	,	PUNCT
easat-8472	138	36	vol	vol	NOUN
easat-8472	138	37	.	.	PROPN
easat-8472	138	38	37	37	NUM
easat-8472	138	39	,	,	PUNCT
easat-8472	138	40	p.	p.	NOUN
easat-8472	138	41	100763	100763	NUM
easat-8472	138	42	,	,	PUNCT
easat-8472	138	43	2023	2023	NUM
easat-8472	138	44	.	.	PUNCT
easat-8472	139	1	https://doi.org/10.1016/j.ctarc.2023.100763	https://doi.org/10.1016/j.ctarc.2023.100763	PROPN
easat-8472	139	2	[	[	X
easat-8472	139	3	3	3	X
easat-8472	139	4	]	]	X
easat-8472	139	5	b.	b.	PROPN
easat-8472	139	6	suresh	suresh	PROPN
easat-8472	139	7	,	,	PUNCT
easat-8472	139	8	mc	mc	PROPN
easat-8472	139	9	et	et	PROPN
easat-8472	139	10	al	al	PROPN
easat-8472	139	11	.	.	PROPN
easat-8472	139	12	,	,	PUNCT
easat-8472	139	13	"	"	PUNCT
easat-8472	139	14	colorectal	colorectal	ADJ
easat-8472	139	15	cancer	cancer	NOUN
easat-8472	139	16	presenting	presenting	NOUN
easat-8472	139	17	as	as	ADP
easat-8472	139	18	bone	bone	NOUN
easat-8472	139	19	metastasis	metastasis	NOUN
easat-8472	139	20	,	,	PUNCT
easat-8472	139	21	"	"	PUNCT
easat-8472	139	22	journal	journal	NOUN
easat-8472	139	23	of	of	ADP
easat-8472	139	24	cancer	cancer	NOUN
easat-8472	139	25	research	research	NOUN
easat-8472	139	26	and	and	CCONJ
easat-8472	139	27	therapeutics	therapeutic	NOUN
easat-8472	139	28	,	,	PUNCT
easat-8472	139	29	vol	vol	NOUN
easat-8472	139	30	.	.	PROPN
easat-8472	139	31	13	13	NUM
easat-8472	139	32	,	,	PUNCT
easat-8472	139	33	no	no	INTJ
easat-8472	139	34	.	.	NOUN
easat-8472	139	35	1	1	NUM
easat-8472	139	36	,	,	PUNCT
easat-8472	139	37	pp	pp	ADJ
easat-8472	139	38	.	.	PUNCT
easat-8472	140	1	80	80	NUM
easat-8472	140	2	-	-	SYM
easat-8472	140	3	83	83	NUM
easat-8472	140	4	,	,	PUNCT
easat-8472	140	5	2017	2017	NUM
easat-8472	140	6	.	.	PUNCT
easat-8472	141	1	https://doi.org/10.4103/0973-1482.181177	https://doi.org/10.4103/0973-1482.181177	PROPN
easat-8472	142	1	[	[	X
easat-8472	142	2	4	4	NUM
easat-8472	142	3	]	]	X
easat-8472	142	4	r.	r.	PROPN
easat-8472	142	5	assi	assi	PROPN
easat-8472	142	6	,	,	PUNCT
easat-8472	142	7	d.	d.	PROPN
easat-8472	142	8	mukherji	mukherji	PROPN
easat-8472	142	9	,	,	PUNCT
easat-8472	142	10	a.	a.	PROPN
easat-8472	142	11	haydar	haydar	PROPN
easat-8472	142	12	,	,	PUNCT
easat-8472	142	13	m.	m.	NOUN
easat-8472	142	14	saroufim	saroufim	PROPN
easat-8472	142	15	,	,	PUNCT
easat-8472	142	16	s.	s.	PROPN
easat-8472	142	17	temraz	temraz	PROPN
easat-8472	142	18	,	,	PUNCT
easat-8472	142	19	and	and	CCONJ
easat-8472	142	20	a.	a.	NOUN
easat-8472	142	21	shamseddine	shamseddine	NOUN
easat-8472	142	22	,	,	PUNCT
easat-8472	142	23	"	"	PUNCT
easat-8472	142	24	metastatic	metastatic	ADJ
easat-8472	142	25	colorectal	colorectal	ADJ
easat-8472	142	26	cancer	cancer	NOUN
easat-8472	142	27	presenting	present	VERB
easat-8472	142	28	with	with	ADP
easat-8472	142	29	bone	bone	NOUN
easat-8472	142	30	marrow	marrow	NOUN
easat-8472	142	31	metastasis	metastasis	NOUN
easat-8472	142	32	:	:	PUNCT
easat-8472	142	33	a	a	DET
easat-8472	142	34	case	case	NOUN
easat-8472	142	35	series	series	NOUN
easat-8472	142	36	and	and	CCONJ
easat-8472	142	37	review	review	NOUN
easat-8472	142	38	of	of	ADP
easat-8472	142	39	literature	literature	NOUN
easat-8472	142	40	,	,	PUNCT
easat-8472	142	41	"	"	PUNCT
easat-8472	142	42	journal	journal	NOUN
easat-8472	142	43	of	of	ADP
easat-8472	142	44	gastrointestinal	gastrointestinal	ADJ
easat-8472	142	45	oncology	oncology	NOUN
easat-8472	142	46	,	,	PUNCT
easat-8472	142	47	vol	vol	NOUN
easat-8472	142	48	.	.	PROPN
easat-8472	142	49	7	7	NUM
easat-8472	142	50	,	,	PUNCT
easat-8472	142	51	no	no	INTJ
easat-8472	142	52	.	.	NOUN
easat-8472	142	53	2	2	NUM
easat-8472	142	54	,	,	PUNCT
easat-8472	142	55	p.	p.	NOUN
easat-8472	142	56	284	284	NUM
easat-8472	142	57	,	,	PUNCT
easat-8472	142	58	2016	2016	NUM
easat-8472	142	59	.	.	PUNCT
easat-8472	143	1	https://doi.org/10.3978/j.issn.2078-6891.2015.092	https://doi.org/10.3978/j.issn.2078-6891.2015.092	NOUN
easat-8472	144	1	[	[	X
easat-8472	144	2	5	5	NUM
easat-8472	144	3	]	]	PUNCT
easat-8472	144	4	h.	h.	PROPN
easat-8472	144	5	s.	s.	PROPN
easat-8472	144	6	park	park	PROPN
easat-8472	144	7	et	et	PROPN
easat-8472	144	8	al	al	PROPN
easat-8472	144	9	.	.	PROPN
easat-8472	144	10	,	,	PUNCT
easat-8472	144	11	"	"	PUNCT
easat-8472	144	12	clinical	clinical	ADJ
easat-8472	144	13	features	feature	NOUN
easat-8472	144	14	and	and	CCONJ
easat-8472	144	15	kras	kras	PROPN
easat-8472	144	16	mutation	mutation	NOUN
easat-8472	144	17	in	in	ADP
easat-8472	144	18	colorectal	colorectal	ADJ
easat-8472	144	19	cancer	cancer	NOUN
easat-8472	144	20	with	with	ADP
easat-8472	144	21	bone	bone	NOUN
easat-8472	144	22	metastasis	metastasis	NOUN
easat-8472	144	23	,	,	PUNCT
easat-8472	144	24	"	"	PUNCT
easat-8472	144	25	scientific	scientific	ADJ
easat-8472	144	26	reports	report	NOUN
easat-8472	144	27	,	,	PUNCT
easat-8472	144	28	vol	vol	NOUN
easat-8472	144	29	.	.	PROPN
easat-8472	145	1	10	10	NUM
easat-8472	145	2	,	,	PUNCT
easat-8472	145	3	no	no	INTJ
easat-8472	145	4	.	.	NOUN
easat-8472	145	5	1	1	NUM
easat-8472	145	6	,	,	PUNCT
easat-8472	145	7	p.	p.	NOUN
easat-8472	145	8	21180	21180	NUM
easat-8472	145	9	,	,	PUNCT
easat-8472	145	10	2020	2020	NUM
easat-8472	145	11	.	.	PUNCT
easat-8472	146	1	[	[	X
easat-8472	146	2	6	6	NUM
easat-8472	146	3	]	]	PUNCT
easat-8472	146	4	x.	x.	NOUN
easat-8472	146	5	li	li	PROPN
easat-8472	146	6	,	,	PUNCT
easat-8472	146	7	w.	w.	PROPN
easat-8472	146	8	hu	hu	PROPN
easat-8472	146	9	,	,	PUNCT
easat-8472	146	10	h.	h.	PROPN
easat-8472	146	11	sun	sun	PROPN
easat-8472	146	12	,	,	PUNCT
easat-8472	146	13	and	and	CCONJ
easat-8472	146	14	h.	h.	PROPN
easat-8472	146	15	gou	gou	PROPN
easat-8472	146	16	,	,	PUNCT
easat-8472	146	17	"	"	PUNCT
easat-8472	146	18	survival	survival	NOUN
easat-8472	146	19	outcome	outcome	NOUN
easat-8472	146	20	and	and	CCONJ
easat-8472	146	21	prognostic	prognostic	ADJ
easat-8472	146	22	factors	factor	NOUN
easat-8472	146	23	for	for	ADP
easat-8472	146	24	colorectal	colorectal	ADJ
easat-8472	146	25	cancer	cancer	NOUN
easat-8472	146	26	with	with	ADP
easat-8472	146	27	synchronous	synchronous	ADJ
easat-8472	146	28	bone	bone	NOUN
easat-8472	146	29	metastasis	metastasis	NOUN
easat-8472	146	30	:	:	PUNCT
easat-8472	146	31	a	a	DET
easat-8472	146	32	population	population	NOUN
easat-8472	146	33	-	-	PUNCT
easat-8472	146	34	based	base	VERB
easat-8472	146	35	study	study	NOUN
easat-8472	146	36	,	,	PUNCT
easat-8472	146	37	"	"	PUNCT
easat-8472	146	38	clinical	clinical	ADJ
easat-8472	146	39	&	&	CCONJ
easat-8472	146	40	experimental	experimental	ADJ
easat-8472	146	41	metastasis	metastasis	NOUN
easat-8472	146	42	,	,	PUNCT
easat-8472	146	43	vol	vol	NOUN
easat-8472	146	44	.	.	PROPN
easat-8472	147	1	38	38	NUM
easat-8472	147	2	,	,	PUNCT
easat-8472	147	3	pp	pp	ADJ
easat-8472	147	4	.	.	PUNCT
easat-8472	148	1	89	89	NUM
easat-8472	148	2	-	-	SYM
easat-8472	148	3	95	95	NUM
easat-8472	148	4	,	,	PUNCT
easat-8472	148	5	2021	2021	NUM
easat-8472	148	6	.	.	PUNCT
easat-8472	149	1	https://doi.org/10.1007/s10585-020-10069-5	https://doi.org/10.1007/s10585-020-10069-5	X
easat-8472	150	1	[	[	X
easat-8472	150	2	7	7	X
easat-8472	150	3	]	]	X
easat-8472	150	4	h.	h.	PROPN
easat-8472	150	5	kawamura	kawamura	PROPN
easat-8472	150	6	et	et	PROPN
easat-8472	150	7	al	al	PROPN
easat-8472	150	8	.	.	PROPN
easat-8472	150	9	,	,	PUNCT
easat-8472	150	10	"	"	PUNCT
easat-8472	150	11	characteristics	characteristic	NOUN
easat-8472	150	12	and	and	CCONJ
easat-8472	150	13	prognostic	prognostic	ADJ
easat-8472	150	14	factors	factor	NOUN
easat-8472	150	15	of	of	ADP
easat-8472	150	16	bone	bone	NOUN
easat-8472	150	17	metastasis	metastasis	NOUN
easat-8472	150	18	in	in	ADP
easat-8472	150	19	patients	patient	NOUN
easat-8472	150	20	with	with	ADP
easat-8472	150	21	colorectal	colorectal	ADJ
easat-8472	150	22	cancer	cancer	NOUN
easat-8472	150	23	,	,	PUNCT
easat-8472	150	24	"	"	PUNCT
easat-8472	150	25	diseases	disease	NOUN
easat-8472	150	26	of	of	ADP
easat-8472	150	27	the	the	DET
easat-8472	150	28	colon	colon	NOUN
easat-8472	150	29	&	&	CCONJ
easat-8472	150	30	rectum	rectum	NOUN
easat-8472	150	31	,	,	PUNCT
easat-8472	150	32	vol	vol	NOUN
easat-8472	150	33	.	.	PROPN
easat-8472	150	34	61	61	NUM
easat-8472	150	35	,	,	PUNCT
easat-8472	150	36	no	no	INTJ
easat-8472	150	37	.	.	NOUN
easat-8472	150	38	6	6	NUM
easat-8472	150	39	,	,	PUNCT
easat-8472	150	40	pp	pp	ADJ
easat-8472	150	41	.	.	PUNCT
easat-8472	150	42	673	673	NUM
easat-8472	150	43	-	-	SYM
easat-8472	150	44	678	678	NUM
easat-8472	150	45	,	,	PUNCT
easat-8472	150	46	2018	2018	NUM
easat-8472	150	47	.	.	PUNCT
easat-8472	151	1	https://doi.org/10.1097/dcr.0000000000001071	https://doi.org/10.1097/dcr.0000000000001071	NOUN
easat-8472	151	2	[	[	X
easat-8472	151	3	8	8	NUM
easat-8472	151	4	]	]	PUNCT
easat-8472	151	5	x.	x.	NOUN
easat-8472	151	6	ma	ma	PROPN
easat-8472	151	7	et	et	PROPN
easat-8472	151	8	al	al	PROPN
easat-8472	151	9	.	.	PROPN
easat-8472	151	10	,	,	PUNCT
easat-8472	151	11	"	"	PUNCT
easat-8472	151	12	a	a	DET
easat-8472	151	13	novel	novel	ADJ
easat-8472	151	14	risk	risk	NOUN
easat-8472	151	15	stratification	stratification	NOUN
easat-8472	151	16	for	for	ADP
easat-8472	151	17	predicting	predict	VERB
easat-8472	151	18	prognosis	prognosis	NOUN
easat-8472	151	19	of	of	ADP
easat-8472	151	20	colorectal	colorectal	ADJ
easat-8472	151	21	cancer	cancer	NOUN
easat-8472	151	22	patients	patient	NOUN
easat-8472	151	23	with	with	ADP
easat-8472	151	24	bone	bone	NOUN
easat-8472	151	25	metastasis	metastasis	NOUN
easat-8472	151	26	,	,	PUNCT
easat-8472	151	27	"	"	PUNCT
easat-8472	151	28	journal	journal	NOUN
easat-8472	151	29	of	of	ADP
easat-8472	151	30	gastrointestinal	gastrointestinal	ADJ
easat-8472	151	31	oncology	oncology	NOUN
easat-8472	151	32	,	,	PUNCT
easat-8472	151	33	vol	vol	NOUN
easat-8472	151	34	.	.	PROPN
easat-8472	151	35	12	12	NUM
easat-8472	151	36	,	,	PUNCT
easat-8472	151	37	no	no	INTJ
easat-8472	151	38	.	.	NOUN
easat-8472	151	39	3	3	NUM
easat-8472	151	40	,	,	PUNCT
easat-8472	151	41	p.	p.	NOUN
easat-8472	151	42	933	933	NUM
easat-8472	151	43	,	,	PUNCT
easat-8472	151	44	2021	2021	NUM
easat-8472	151	45	.	.	PUNCT
easat-8472	152	1	https://doi.org/10.21037/jgo-20-586	https://doi.org/10.21037/jgo-20-586	VERB
easat-8472	153	1	[	[	X
easat-8472	153	2	9	9	NUM
easat-8472	153	3	]	]	X
easat-8472	153	4	y.	y.	PROPN
easat-8472	153	5	li	li	PROPN
easat-8472	153	6	,	,	PUNCT
easat-8472	153	7	x.	x.	PROPN
easat-8472	153	8	cheng	cheng	PROPN
easat-8472	153	9	,	,	PUNCT
easat-8472	153	10	c.	c.	PROPN
easat-8472	153	11	zhong	zhong	PROPN
easat-8472	153	12	,	,	PUNCT
easat-8472	153	13	and	and	CCONJ
easat-8472	153	14	y.	y.	PROPN
easat-8472	153	15	yuan	yuan	PROPN
easat-8472	153	16	,	,	PUNCT
easat-8472	153	17	"	"	PUNCT
easat-8472	153	18	primary	primary	ADJ
easat-8472	153	19	tumor	tumor	NOUN
easat-8472	153	20	resection	resection	NOUN
easat-8472	153	21	plus	plus	CCONJ
easat-8472	153	22	chemotherapy	chemotherapy	NOUN
easat-8472	153	23	versus	versus	ADP
easat-8472	153	24	chemotherapy	chemotherapy	NOUN
easat-8472	153	25	alone	alone	ADV
easat-8472	153	26	for	for	ADP
easat-8472	153	27	colorectal	colorectal	ADJ
easat-8472	153	28	cancer	cancer	NOUN
easat-8472	153	29	patients	patient	NOUN
easat-8472	153	30	with	with	ADP
easat-8472	153	31	synchronous	synchronous	ADJ
easat-8472	153	32	bone	bone	NOUN
easat-8472	153	33	metastasis	metastasis	NOUN
easat-8472	153	34	,	,	PUNCT
easat-8472	153	35	"	"	PUNCT
easat-8472	153	36	medicina	medicina	NOUN
easat-8472	153	37	,	,	PUNCT
easat-8472	153	38	vol	vol	NOUN
easat-8472	153	39	.	.	PROPN
easat-8472	154	1	59	59	NUM
easat-8472	154	2	,	,	PUNCT
easat-8472	154	3	no	no	INTJ
easat-8472	154	4	.	.	NOUN
easat-8472	154	5	8	8	NUM
easat-8472	154	6	,	,	PUNCT
easat-8472	154	7	p.	p.	NOUN
easat-8472	154	8	1384	1384	NUM
easat-8472	154	9	,	,	PUNCT
easat-8472	154	10	2023	2023	NUM
easat-8472	154	11	.	.	PUNCT
easat-8472	155	1	https://doi.org/10.3390/medicina59081384	https://doi.org/10.3390/medicina59081384	PROPN
easat-8472	155	2	[	[	X
easat-8472	155	3	10	10	NUM
easat-8472	155	4	]	]	PUNCT
easat-8472	155	5	s.-j	s.-j	PROPN
easat-8472	155	6	.	.	PUNCT
easat-8472	156	1	baek	baek	PROPN
easat-8472	156	2	,	,	PUNCT
easat-8472	156	3	h.	h.	PROPN
easat-8472	156	4	hur	hur	PROPN
easat-8472	156	5	,	,	PUNCT
easat-8472	156	6	b.-s	b.-s	PROPN
easat-8472	156	7	.	.	PUNCT
easat-8472	157	1	min	min	PROPN
easat-8472	157	2	,	,	PUNCT
easat-8472	157	3	s.-h	s.-h	NOUN
easat-8472	157	4	.	.	PUNCT
easat-8472	158	1	baik	baik	NOUN
easat-8472	158	2	,	,	PUNCT
easat-8472	158	3	k.-y	k.-y	PROPN
easat-8472	158	4	.	.	PUNCT
easat-8472	159	1	lee	lee	PROPN
easat-8472	159	2	,	,	PUNCT
easat-8472	159	3	and	and	CCONJ
easat-8472	159	4	n.-k	n.-k	PROPN
easat-8472	159	5	.	.	PUNCT
easat-8472	160	1	kim	kim	PROPN
easat-8472	160	2	,	,	PUNCT
easat-8472	160	3	"	"	PUNCT
easat-8472	160	4	the	the	DET
easat-8472	160	5	characteristics	characteristic	NOUN
easat-8472	160	6	of	of	ADP
easat-8472	160	7	bone	bone	NOUN
easat-8472	160	8	metastasis	metastasis	NOUN
easat-8472	160	9	in	in	ADP
easat-8472	160	10	patients	patient	NOUN
easat-8472	160	11	with	with	ADP
easat-8472	160	12	colorectal	colorectal	ADJ
easat-8472	160	13	cancer	cancer	NOUN
easat-8472	160	14	:	:	PUNCT
easat-8472	160	15	a	a	DET
easat-8472	160	16	long	long	ADJ
easat-8472	160	17	-	-	PUNCT
easat-8472	160	18	term	term	NOUN
easat-8472	160	19	report	report	NOUN
easat-8472	160	20	from	from	ADP
easat-8472	160	21	a	a	DET
easat-8472	160	22	single	single	ADJ
easat-8472	160	23	institution	institution	NOUN
easat-8472	160	24	,	,	PUNCT
easat-8472	160	25	"	"	PUNCT
easat-8472	160	26	world	world	NOUN
easat-8472	160	27	journal	journal	NOUN
easat-8472	160	28	of	of	ADP
easat-8472	160	29	surgery	surgery	NOUN
easat-8472	160	30	,	,	PUNCT
easat-8472	160	31	vol	vol	NOUN
easat-8472	160	32	.	.	PROPN
easat-8472	160	33	40	40	NUM
easat-8472	160	34	,	,	PUNCT
easat-8472	160	35	pp	pp	ADJ
easat-8472	160	36	.	.	PUNCT
easat-8472	161	1	982	982	NUM
easat-8472	161	2	-	-	PUNCT
easat-8472	161	3	986	986	NUM
easat-8472	161	4	,	,	PUNCT
easat-8472	161	5	2016	2016	NUM
easat-8472	161	6	.	.	PUNCT
easat-8472	162	1	https://doi.org/10.1007/s00268-015-3296-x	https://doi.org/10.1007/s00268-015-3296-x	PRON
easat-8472	163	1	[	[	X
easat-8472	163	2	11	11	NUM
easat-8472	163	3	]	]	X
easat-8472	163	4	f.	f.	PROPN
easat-8472	163	5	liu	liu	PROPN
easat-8472	163	6	et	et	PROPN
easat-8472	163	7	al	al	PROPN
easat-8472	163	8	.	.	PROPN
easat-8472	163	9	,	,	PUNCT
easat-8472	163	10	"	"	PUNCT
easat-8472	163	11	prognostic	prognostic	ADJ
easat-8472	163	12	risk	risk	NOUN
easat-8472	163	13	factors	factor	NOUN
easat-8472	163	14	in	in	ADP
easat-8472	163	15	patients	patient	NOUN
easat-8472	163	16	with	with	ADP
easat-8472	163	17	bone	bone	NOUN
easat-8472	163	18	metastasis	metastasis	NOUN
easat-8472	163	19	from	from	ADP
easat-8472	163	20	colorectal	colorectal	ADJ
easat-8472	163	21	cancer	cancer	NOUN
easat-8472	163	22	,	,	PUNCT
easat-8472	163	23	"	"	PUNCT
easat-8472	163	24	tumor	tumor	NOUN
easat-8472	163	25	biology	biology	NOUN
easat-8472	163	26	,	,	PUNCT
easat-8472	163	27	vol	vol	NOUN
easat-8472	163	28	.	.	PROPN
easat-8472	163	29	37	37	NUM
easat-8472	163	30	,	,	PUNCT
easat-8472	163	31	pp	pp	ADJ
easat-8472	163	32	.	.	PUNCT
easat-8472	164	1	16127	16127	NUM
easat-8472	164	2	-	-	SYM
easat-8472	164	3	16134	16134	NUM
easat-8472	164	4	,	,	PUNCT
easat-8472	164	5	2016	2016	NUM
easat-8472	164	6	.	.	PUNCT
easat-8472	165	1	https://doi.org/10.1007/s13277-016-5465-4	https://doi.org/10.1007/s13277-016-5465-4	NUM
easat-8472	165	2	https://creativecommons.org/licenses/by/4.0/	https://creativecommons.org/licenses/by/4.0/	PROPN
easat-8472	165	3	https://doi.org/10.1016/j.ctarc.2023.100763	https://doi.org/10.1016/j.ctarc.2023.100763	PROPN
easat-8472	165	4	https://doi.org/10.4103/0973-1482.181177	https://doi.org/10.4103/0973-1482.181177	PROPN
easat-8472	165	5	https://doi.org/10.3978/j.issn.2078-6891.2015.092	https://doi.org/10.3978/j.issn.2078-6891.2015.092	VERB
easat-8472	165	6	https://doi.org/10.1007/s10585-020-10069-5	https://doi.org/10.1007/s10585-020-10069-5	NUM
easat-8472	165	7	https://doi.org/10.1097/dcr.0000000000001071	https://doi.org/10.1097/dcr.0000000000001071	PROPN
easat-8472	165	8	https://doi.org/10.21037/jgo-20-586	https://doi.org/10.21037/jgo-20-586	NOUN
easat-8472	165	9	https://doi.org/10.3390/medicina59081384	https://doi.org/10.3390/medicina59081384	PROPN
easat-8472	165	10	https://doi.org/10.1007/s00268-015-3296-x	https://doi.org/10.1007/s00268-015-3296-x	PROPN
easat-8472	165	11	https://doi.org/10.1007/s13277-016-5465-4	https://doi.org/10.1007/s13277-016-5465-4	NUM