2021 UNC Greensboro PDE Conference, Electronic Journal of Differential Equations, Conference 26 (2022), pp. 139–149. ISSN: 1072-6691. URL: http://ejde.math.txstate.edu or http://ejde.math.unt.edu WELLPOSEDNESS OF KELLER-SEGEL SYSTEMS IN MIXED NORM SPACES TIMOTHY ROBERTSON Abstract. We study the well-posedness of the Cauchy problem for the Keller- Segal system in the setting of mixed norm spaces. We prove existence of mild solutions in scaling invariant spaces and uniqueness in a special case. These results allow for existence and uniqueness when the initial data has anisotropic properties. In particular, persistence of anisotropic properties under the evo- lution is demonstrated which could be of biological interest. 1. Introduction In this article, we study the following Cauchy problem for the Keller-Segel system of parabolic equations ut = ∆u−∇ · (u∇v), in Rn × (0, T ), vt = ∆v −A(t)v +B(x, t)u in Rn × (0, T ), u(0, ·) = u0(·) in Rn, v(0, ·) = v0(·) in Rn, (1.1) where in (1.1) the functions u, v : Rn × (0, T ) → R are unknown solutions with T ∈ (0,∞] and n ∈ N, the functions u0, v0 : Rn → (0,∞) are given measurable initial data, and the functions A : (0, T ) → [0,∞) and B : Rn × (0, T ) → (0,∞) are given and measurable. The Keller-Segel system was proposed in [7] to describe chemotactic aggregation of cellular slime molds which move preferentially towards relatively high concentrations of a chemical secreted by the amoebae themselves. In this context, u(x, t) represents the cell density of the slime molds at position x and time t, and similarly the concentration of the chemical substance at position x and time t is represented by v(x, t). Our goal is to develop the existence and uniqueness of solutions of (1.1) in the setting of anisotropic spaces. The motivation of the study comes from applications where initial data and solutions can concentrate and behave differently in differ- ent spatial variables. Mathematically, our results demonstrate the persistence of anisotropic properties under the evolution of the Keller-Segal system, which does not seem to be trivial. To put our study into perspective, we recall the definition of the anisotropic (mixed norm) space. For a given ~p = (p1, . . . , pn) ∈ [1,∞)n, 2020 Mathematics Subject Classification. 35A01, 35A02, 92C17. Key words and phrases. Mixed norm spaces; Keller-Segel model; semigroup methods. ©2022 This work is licensed under a CC BY 4.0 license. Published August 25, 2022. 139 140 T. ROBERTSON EJDE-2022/CONF/26 the mixed norm Lebesgue space L~p(Rn) is the set of all measurable functions f : Rn → R such that the mixed norm ‖f‖~p = (∫ R · · · (∫ R (∫ R |f(x1, x2, . . . , xn)|p1dx1 ) p2 p1 dx2 ) p3 p2 · · · dxn )1/pn <∞. A similar definition can be formed if pi =∞ for some i = 1, 2, . . . , n. Similarly, for q ∈ [1,∞) and ~p = (p1, . . . , pn) ∈ [1,∞)n, we write Lq((0, T );L~p(Rn)) to represent the space consisting of all u : (0, T )→ L~p(Rn) such that ‖u‖T,q,~p = (∫ T 0 ‖u(·, t)‖q~pdt )1/q <∞. The definition of mixed norm Sobolev space follows naturally from the definition of the mixed norm. Definition 1.1. Let ~I = (I1, . . . , In) ∈ [1,∞)n. The Sobolev space H ~I(Rn) con- sists of all measurable functions f : Rn → R such that the weak derivative Df exists and ‖f‖H~I(Rn) := ‖f‖L~I(Rn) + ‖Df‖L~I(Rn) <∞. Now, the mild solutions to (1.1) are defined as follows. Definition 1.2. A pair of functions (u, v) : Rn × (0,∞)→ R2 is said to be a mild solution to (1.1) if u(x, t) = et∆u0 − ∫ t 0 ∇ · e(t−s)∆(u · ∇v)ds, v(x, t) = e−tet∆v0 + ∫ t 0 e−Ā(t−s)e(t−s)∆(Bu(s))ds for all t ∈ (0, T ), provided the integrals are well-defined. We note that the following assumption on the coefficients A,B are used through- out this article: there is Λ > 0 such that The coefficients A,B are assumed to satisfy the condition that there is Λ > 0 such that 0 ≤ Ā(t) := ∫ t 0 A(s) ds and 0 ≤ B(x, t) ≤ Λ, ∀(x, t) ∈ Rn × (0, T ). (1.2) We now state our main results. Our first result is on the local time existence of solutions in the mixed-norm space. Theorem 1.3. Let ~I = (I1, . . . , In), ~J = (J1, . . . , Jn) ∈ (1,∞)n satisfy 1 2 n∑ k=1 1 Ik = n∑ k=1 1 Jk = 1. Also let ~r = (r1, . . . , rn), ~R = (R1, . . . , Rn) be in (1,∞)n and 1 < q < Q <∞ such that 1 < rk < Rk <∞, Ik < rk, Jk < Rk for k = 1, 2, . . . , n and 1 q + 1 2 n∑ k=1 1 rk = 1, 1 Q + 1 2 n∑ k=1 1 Rk = 1 2 . (1.3) Then under assumption (1.2) and for a pair functions u0, v0 : Rn → R satisfying u0 ∈ L~I(R n), v0 ∈ H ~J(Rn) EJDE-2018/CONF/26 MIXED NORM WELLPOSEDNESS 141 there exist T > 0 and a pair of functions u ∈ Lq((0, T );L~r(Rn)) and v ∈ LQ((0, T );H ~R(Rn)) that solves (1.1) in the mild sense. Observe that the conditions on q,Q,~r and ~R in Theorem 1.3 gives invariance under the heat scaling. Precisely, for a given pair of solutions (u, v) and for λ > 0, let uλ(x, t) = λ2u(λx, λ2t), vλ(t, x) = v(λx, λ2t), x ∈ Rn, t ∈ (0, T/λ). Then ‖uλ‖T/λ,q,~r = ‖u‖T,q,~r, ‖∇vλ‖T/λ,Q,~R = ‖∇v‖T,Q,~R, ∀λ > 0 (1.4) if and only if 1 = 1 q + 1 2 n∑ k=1 1 rk , 1 2 = 1 Q + 1 2 n∑ k=1 1 Rk . Observe that the condition (1.4) must be the correct scaling condition since (uλ, vλ) is a solution of (1.1) when A(t) is replaced by A(λ2t)/λ2 and B(x, t) is replaced by B(λx, λ2t). For a more extensive discussion of scaling see [5]. Our second result Theorem 1.4 shows uniqueness of mild solutions under a special case of Theorem 1.3. Theorem 1.4. Suppose ~I = (I1, . . . , In), ~J = (J1, . . . , Jn) in (1,∞)n satisfy 1 =∑n k=1 1/Jk with Ik = 1 2Jk for k = 1, . . . , n and u0 ∈ L~I(R n), ∇v0 ∈ L ~J(Rn). If (u, v) is a mild solution of (1.1) and satisfies u ∈ C((0, T );L~I(R n)), ∇v ∈ C((0, T );L ~J(Rn)) (1.5) then (u, v) is the only mild solution that satisfies (1.5) on Rn × (0, T ). The wellposedness of the Keller-Segel model in its various forms has been ex- tensively studied in the literature. Perhaps the most notable result thus far is the classical result that for n = 2 the Keller-Segel system has a solution if and only if the critical mass is less than 8π, as discussed in [3] and [4]. Unfortunately, the problem of existence is not so clear when n ≥ 3. We do not present an exhaustive review here and refer interested readers to the recent review paper [1]. However, we do highlight several pertinent results. Global existence for small initial data u0 ∈ Ln/2w and v0 ∈ BMO was shown in [8]. Small time existence was shown for initial data u0 ∈ Ln/2 and v0 ∈ H1,n/2 in [9]. Our results extend the latter result to mixed norm spaces using techniques established in [12, 13]. The proof of Theorem 1.3 follows from the standard fixed point argument using Picard’s iteration technique. To implement this method, we need to derive several estimates of the heat semi-group in mixed norm spaces which could be of indepen- dent interest. In Section 2 we introduce and review several analysis results and estimates on Sobolev imbedding theorems and semi-groups in mixed-norm spaces. In particular, in Lemma 2.2 below, the smoothing estimate of the heat semi-group in mixed-norm spaces is introduced, and this result seems to be new. The proof of Lemma 2.2 follows from the Marcinkiewicz interpolation theorem. The proof of Theorem 1.3 is then given in Section 3. To prove Theorem 1.4, we take the 142 T. ROBERTSON EJDE-2022/CONF/26 difference between the two solutions and then control it. The challenging part is to control the nonlinear terms in the mixed-norm spaces. Delicate details with algebra in mixed-norms are then required and all are presented in Section 4. 2. Preliminary inequalities and estimates in mixed-norm spaces The proofs of Theorems 1.3, 3.1 rely on several technical lemmas stated below. The proof of Lemma 2.1 is given in [12] so it is omitted here. Lemma 2.1. Let ~p = (p1, . . . , pn) and ~q = (q1, . . . , qn) be in [1,∞]n such that pk ≤ qk for k = 1, 2, . . . , n. Then there exists C = C(~p, ~q, n) > 0 such that ‖et∆f‖~q ≤ Ct− 1 2 ∑n k=1( 1 pk − 1 qk )‖f‖~p, ‖∇et∆f‖~q ≤ Ct− 1 2− 1 2 ∑n k=1( 1 pk − 1 qk )‖f‖~p, (2.1) for all f ∈ L~p(Rn) and for all t > 0. Lemma 2.2 is an interpolation result yielding control of norms of semi-group operators. Here we follow the approach of the recent work [13, Lemma 3.2]. The proof is included for completeness. Lemma 2.2. Let q ∈ (1,∞), ~p = (p1, . . . , pn) and ~r = (r1, . . . , rn) be in (1,∞)n satisfying pk < rk for k = 1, . . . , n and 1 q = l 2 + 1 2 n∑ k=1 ( 1 pk − 1 rk ) . Then for l = 0, 1 there is Cl = C(~p, q, n, l) > 0 such that(∫ t 0 ‖Dles∆f‖q~rds )1/q ≤ Cl‖f‖~p, for all f ∈ L~p(Rn). Proof. Let ~p′ = (p1, . . . , pn−1). To employ the Marcinkiewicz interpolation theorem consider the space X = {f : measurable f : R→ L~p′(R n−1)}, with ‖ · ‖X := ‖ · ‖L~p′ , and the operator Tl : L~r(X)→ Lαw defined by Tlf : f → ‖Dlet∆f‖~r, where Lαw is the weak Lebesgue space with parameter α. For fixed l Lemma 2.1 yields ‖Tl(f)‖Lαw <∞ if 1 α = l 2 − 1 2 n∑ k=1 ( 1 pk − 1 rk ) . We define α(pn) = ( l 2 − 1 2 n−1∑ k=1 ( 1 pk − 1 rk ) + 1 2rn − 1 2pn )−1 . Note that p̂ and p̃ may be chosen such that 1 < p̂ < pn < p̃ < rn, EJDE-2018/CONF/26 MIXED NORM WELLPOSEDNESS 143 and by an appropriate choice of θ ∈ (0, 1) the equality 1 pn = 1− θ p̂ + θ p̃ holds. Clearly, 1 q = 1 α(pn) = 1− θ α(p̂) + θ α(p̃) . Since Tl is of weak type (p̂, α(p̂)) and (p̃, ˆ̃p), by Marcinkiewicz interpolation Tl must be of strong type (pn, q). Observing that ‖Tl‖q ≤ C‖f‖Lpn (X) = C‖f‖~p completes the proof. � Finally, this section concludes by recalling several function space inequalities that will be used in the uniqueness proof. Lemma 2.3 generalizes Hölder’s inequality, while Lemma 2.4 generalizes Young’s inequality to the Lorentz space setting. Recall that Lp,q is the Lorentz space with parameters p and q, with norm ‖f‖Lp,q = (∫ ∞ 0 p1/qsq−1m({x : |f(x)| ≥ s}) q p ds )1/q . The proof for both lemmas is given in [10]. Lemma 2.3. Let q,Q ∈ [1,∞] and p, P ∈ (1,∞) such that 1 p + 1 P < 1. Then there exists C = C(p, P, q,Q) > 0 such that ‖fg‖ L 1 p + 1 P ,min{q,Q} ≤ C‖f‖Lp,q‖g‖LP,Q for f ∈ Lp,q and g ∈ LP,Q. Lemma 2.4. Let z, Z ∈ [1,∞] and p, q ∈ (1,∞) such that 1 < 1 p + 1 q < 2. Then for r defined by 1 r = 1 p + 1 q − 1 there exists C = C(p, q, z, Z) > 0 such that ‖f ∗ g‖Lr,min{z,Z} ≤ C‖f‖Lp,z‖g‖Lp,Z . for f ∈ Lp,z and g ∈ Lq,Z . The last lemma is a special case of the Sobolev Embedding Theorem in the mixed norm setting found in [2]. Lemma 2.5. Let ~I, ~J ∈ (1,∞)n and ~p = (p1, . . . , pn) be defined by pk = ( 1 Ik + 1 Jk )−1. Then there exists a constant C = C(n, ~I, ~J) > 0 such that ‖f‖~I ≤ C [ ‖∇f‖~p + ‖f‖~p ] for all f ∈ H~p(Rn). 144 T. ROBERTSON EJDE-2022/CONF/26 3. Proof of Theorem 1.3 The proof of Theorem 1.3 combines Picard iteration with estimates of the heat semigroup. Concluding the iteration argument requires the following elementary lemma, the proof of which is provided in the appendix. Lemma 3.1. Let a1, b1, C,K > 0 be given real numbers. Suppose 0 < a1 < (b1C−1)2 4BC2 and 0 < b1 < 1 C . Then the sequences {an}n and {bn}n defined recursively by an+1 = a1 + Canbn bn+1 = b1 + CKan (3.1) converge. We now turn to the proof of Theorem 1.3. Proof. We define ~p = (p1, . . . , pn) by pk = ( 1 rk + 1 Rk )−1 for k = 1, . . . , n and z by z = ( 1 q + 1 Q )−1. Let a1 = ‖et∆u0‖q,~r. Then it follows from Lemma 2.2 that a1 ≤ N‖u0‖~p for N = N(n,~r, q). Let um+1 = et∆u0 − ∫ t 0 ∇ · e(t−s)∆(um · ∇vm)ds, vm+1(x, t) = e−tet∆v0 + ∫ t 0 e−Ā(t−s)e(t−s)∆(Bum(s))ds. Note that the initial data u0 and v0 are the first terms of the sequences {um}∞m=0 and {vm}∞m=0, respectively. Applying Minkowski’s inequality and Lemma 2.1 yields∥∥∫ t 0 ∇ · e(t−s)∆(um∇vm)ds‖~r ≤ ∫ t 0 ‖∇ · e(t−s)∆(um∇vm)‖~rds ≤ ∫ t 0 (t− s)− 1 2− 1 2 ∑n k=1( 1 pk − 1 rk )‖um∇vm‖~pds ≤ ∫ t 0 (t− s)− 1 2− 1 2 ∑n k=1 1 Rk ‖um‖~r‖∇vm‖~Rds Recalling that 1 q = 1 2 − 1 2 n∑ k=1 ( 1 pk − 1 rk ) , the Hardy-Littlewood-Sobolev inequality and Hölder’s inequality give∥∥∫ t 0 ∇ · e(t−s)∆(um∇vm)ds ∥∥ q,~r ≤ ∥∥ ∫ t 0 (t− s)− 1 2− 1 2 ∑n k=1 1 Rk ‖um‖~r‖∇vm‖~Rds ∥∥ q ≤ C‖‖um‖~r‖∇vm‖~R‖z ≤ C‖um‖q,~r‖∇vm‖Q,~R for some C = C(n, q,Q, ~R). Letting am = ‖um‖q,~r and bm = ‖∇vm‖Q,~R it follows that ‖um+1‖q,~r ≤ a1 + C‖um‖q,~r‖∇vm‖Q,~R ≤ a1 + Cambm. Similarly, we observe that b1 = ‖∇e−Ātet∆v0‖Q,~R = ∥∥e−Āt∇et∆v0 ∥∥ Q,~R ≤ ‖∇et∆v0‖Q,~R ≤ N‖v0‖~P . EJDE-2018/CONF/26 MIXED NORM WELLPOSEDNESS 145 Using the same estimation scheme as above we obtain that ‖vm+1‖Q,~R ≤ b1 + CΛ‖um‖q,~r. In detail ‖vm+1‖Q,~R ≤ b1 + ∥∥∫ t 0 ‖∇e−Ā(t−s)e(t−s)∆(Bum)‖~Rds ∥∥ Q ≤ b1 + ΛC ∥∥∫ t 0 (t− s)− 1 2− 1 2 ∑n k=1( 1 rk − 1 Rk )‖um‖~rds ∥∥ Q ≤ b1 + ΛC‖um‖q,~r ≤ b1 + ΛCam. where the Hardy-Littlewood inequality justifies the second inequality. The constant C may not be the same constant as in the estimate for um, but we take C to be the maximum of the two constants. Applying Lemma 3.1 gives the convergence of {‖um‖q,~r}m and {‖∇vm‖Q,~R}m. Let X = sup m ‖um‖T∗,q,~r, Y = sup m ‖∇vm‖T∗,Q,~R. Observe that for T = T ∗ > 0 small enough X < 1 4C2B and Y < 1 4C . Thus, for each m ≥ 2, ‖um+1 − um‖T∗,q,~r = ‖ ∫ t 0 ∇ · e(t−s)∆(um∇vm − um−1∇vm−1)ds‖T∗,~r ≤ CY ‖um − um−1‖T∗,q,~r + CX‖∇vm −∇vm−1‖T∗,Q,~R) ≤ CY ‖um − um−1‖T∗,q,~r + C2BX‖um − um−1‖T∗,q,~r) ≤ 1 2 ‖um − um−1‖T∗,q,~r. Clearly, {um}m is Cauchy in Lq((0, T ∗), L~r(Rn)), which in turn implies that {vm}m is Cauchy in LQ((0, T ∗), L~R(Rn)). Replacing um with its limit in the above estimate and using a similar strategy for vm shows that the limits are indeed mild solutions. Recall that this scheme holds provided that 0 < b1 < 1 C and 0 < a1 < (b1C−1)2 4ΛC2 , which holds if T ∗ is chosen sufficiently small. Although there are many choices, it suffices for to T ∗ small enough that b1 < 1 2C and a1 < 1 16Λ . � To demonstrate the utility of this result we now give a short example. Example 3.2. Choose Ik > 1 such that ∑n k=1 1 Ik < 4 and Ik 6= Ij for k 6= j. Then we have q = ( 1− 1 4 1 Ik )−1 > 1 and by Theorem 1.3 the existence of solutions u ∈ Lq((0, T );L2~I(R n)) v ∈ L2q((0, T );H4~I(Rn)) for initial data u0 ∈ L~I(R n) and v0 ∈ H2~I(Rn). This example case compares naturally to [9, Theorem 1], but covers a distinctly different class of initial data. 146 T. ROBERTSON EJDE-2022/CONF/26 4. Proof of uniqueness In this section the second main result Theorem 1.4 is proved. The idea of the proof is to obtain an inequality of the form ‖u2 − u1‖T,p,~I ≤ F (T )‖u2 − u1‖T,p,~I where F (T ) is a continuous function of T and u1, u2 are any two solutions to (1.1). Provided F (T ) < 1 for small enough T , we obtain uniqueness for small time. Extending the local uniqueness to the entire interval of existence is then possible using a contradiction argument. Proof. Our strategy is to estimate the difference between two solutions satisfying (1.5) and show that it must be zero. Namely, let (u1, v1) and (u2, v2) be two mild solutions that satisfy (1.5). It is convenient to define the following: (1) G(t; f, g) = ∫ t 0 ∇e(t−s)∆(fg)ds for f : Rn×(0, T )→ R and g : Rn×(0, T )→ Rn (2) w1(t) = ∫ t 0 e−Ā(t−s)e(t−s)∆(∇(Bu1))ds (3) w2(t) = −G(t;u2, v2) (4) u = u1 − u2 (5) v = v1 − v2 Since u1 and u2 are both mild solutions subtraction and substitution yields: u(x, t) = −G(t;u1,∇v1) +G(t;u2,∇v2) = −G(t;u1,∇v1) +G(t;u2,∇v1)−G(t;u2,∇v1) +G(t;u2,∇v2) = −G(t;u1 − u2,∇v1)−G(t;u2,∇v1 −∇v2) = −G(t;u,∇v1)−G(t;u2,∇v) = −G(t;u, e−Ātet∆∇v0 + w1(t))−G(t; et∆u0 + w2(t)) = −G(t;u, e−Ātet∆∇v0)−G(t;u,w1(t)) −G(t; et∆u0,∇v)−G(t;w2(t),∇v) := T1 + T2 + T3 + T4. (4.1) It remains to estimate each Tk. Formally, for p ∈ (2,∞) with ~z = (z1, . . . , zn) given by zk = ( 1 Ik + 1 Jk )−1 for k = 1, . . . , n: ‖(−∆)−1/2(uw1)‖T,p,~I ≤ C‖uw1‖T,p,~z ≤ C‖‖u‖~I‖w1‖ ~J‖Lp ≤ C‖u‖T,p,~I ( sup s∈(0,T ) ‖w1‖ ~J ) . (4.2) The first inequality is justified by Lemma 2.5 and the fact that uw1 is integrable, and the second by Hölder’s inequality. To justify the third inequality note that ‖u‖T,p,~I ≤ T‖u‖C((0,T );L~I(Rn)) <∞. Since ‖e−Ātet∆v0‖ ~J ≤ C‖Gt‖L∞(Rn)‖∇v0‖ ~J ≤ C‖∇v0‖ ~J , it follows that ‖w1‖C((0,T ),L~I(Rn)) <∞. EJDE-2018/CONF/26 MIXED NORM WELLPOSEDNESS 147 Applying the results found in [6], [11] and using (4.2) to estimate T2 yields: ‖G(t;u,w1)‖T,p,~I ≤ ∥∥ ∫ t 0 (−∆)1/2e(t−s)∆(uw1)ds ∥∥ T,p,~I ≤ ∥∥ ∫ t 0 (−∆)e(t−s)∆(−∆)−1/2(uw1)ds ∥∥ T,p,~I ≤ C‖(−∆)−1/2(uw1)‖T,p,~I ≤ C‖u‖Lp((0,T );L~I) ( sup s∈(0,T ) ‖w1‖ ~J ) (4.3) Now applying the same process to T4 it follows that w2(t) ∈ C((0, T );L~I(R n)), and ‖∇v‖T,p, ~J <∞, and so ‖(−∆)−1/2w2∇v‖T,p,~I ≤ C‖∇v‖T,p, ~J ( sup s∈(0,T ) ‖w2‖~I ) . Hence, ‖G(t;w2,∇v)‖T,p,~I ≤ C‖∇v‖T,p, ~J ( sup s∈(0,T ) ‖w2‖~I ) . (4.4) Turning our attention to T1, Lemma 2.1 yields sup s∈(0,∞) s1/2 ∥∥es∆∇v0 ∥∥ L∞(Rn) ≤ C sup s∈(0,∞) s1/2s−1/2‖∇v0‖ ~J = C‖∇v0‖ ~J . Using Minkowski’s inequality, and the Hölder and Young inequalities for Lorentz spaces we find that ‖G(t;u, e−Ātet∆∇v0)‖T,p,~I ≤ ∥∥∫ t 0 ‖∇e(t−s)∆(ue−Āses∆∇v0)‖~Ids ∥∥ Lp ≤ C ∥∥∫ t 0 s−1/2(t− s)−1/2‖s1/2es∆∇v0‖L∞‖u‖~Ids ∥∥ Lp ≤ C‖∇v0‖ ~J ∥∥ ∫ t 0 s−1/2(t− s)−1/2‖u‖~Ids ∥∥ Lp ≤ C‖s−1/2‖u‖~I‖L 2p p+2 ,p ≤ C‖‖u‖~I‖Lp,p = C‖u‖Lp((0,T );L~I(Rn)). (4.5) To estimate T3 observe that because 1 = ∑n k=1 ( 1 Ik − 1 Jk ) , Lemma 2.1 gives sup s∈(0,∞) s1/2‖es∆u0‖ ~J ≤ C‖u0‖~I . Estimating as before yields ‖G(t; et∆u0,∇v)‖T,p,~I ≤ C ∥∥∫ ‖es∆u0‖ ~J‖∇v‖ ~J(t− s)−1/2s1/2s−1/2ds ∥∥ Lp ≤ C‖u0‖~I‖∇v‖ ~J ≤ C‖u0‖~I‖u‖L~I (4.6) 148 T. ROBERTSON EJDE-2022/CONF/26 where the integral representation of v in terms of u and the Sobolev embedding theorem to obtain the last inequality. Altogether, (4.5), (4.3), (4.6) and (4.4) give ‖u‖T,p,~I ≤ C(n, p)f(T )‖u‖T,p,~I . Observing that f(T ) → 0 as T → 0 it follows that for T1 ≤ Tmax small enough u = 0 and so v = 0, where Tmax is the maximal existence time. Let T1 be the maximal value for which u = 0. By a linear shift the calculation above applies equally well when the time interval (T1, T1 + δ) with T1 + δ ≤ Tmax, which is a contradiction to the definition of T1. Hence T1 = Tmax, proving the theorem. � 5. Appendix We provide the proof of Lemma 3.1 via induction and the Monotone Convergence theorem. Proof. Limiting values (a, b) = limn→∞(an, bn) must satisfy a = a1 + Cab b = b1 + CKa. Thus, a solves the quadratic equation 0 = a1 + (b1C − 1)a+ CK2a2, and so a = −(b1C − 1)± √ (b1C − 1)2 − 4a1KC2 2KC2 . Provided that −(b1C − 1) > 0 and (b1C − 1)2 − 4a1KC 2 > 0, it is clear that both values of a are positive. Choose the smaller value of a, setting a = −(b1C − 1)− √ (b1C − 1)2 − 4a1KC2 2KC2 . Then b = b1 +KC (−(b1C − 1)− √ (b1C − 1)2 − 4a1KC2 2KC2 ) Note that both {an}n and {bn}n are monotonically increasing if a1, b1 > 0, giving (a, b) = limn→∞(an, bn) if an ≤ a and bn ≤ b for all n ∈ N. Observe that if ak ≤ a and bk ≤ b for all k ≤ n then an+1 = a1 + Canbn ≤ a1 + Cab = a, bn+1 = b1 +KCan ≤ b1 +KCa = b. By mathematical induction it suffices to show that a1 ≤ a and b1 ≤ b. The inequality for b1 is trivially true, so all that remains is to show that a1 ≤ a. A straightforward calculation shows that this inequality holds if 0 ≤ a2 1(2KC2)2, which is clearly true. Observe that −(b1C − 1) > 0 iff b1 < 1 C and (b1C − 1)2 − 4a1KC 2 > 0 if and only if a1 < (b1C−1)2 4KC2 . � EJDE-2018/CONF/26 MIXED NORM WELLPOSEDNESS 149 References [1] G. Arumugam, J. Tyagi; Keller-Segel Chemotaxis Models: A Review Acta Applied Math, (2021) 171:6. [2] O. V. Besov, V. P. Il’In, S. M. Nikol’skii; Integral Representations of Functions and Imbedding Theorems, Volume I. V. H. Winston & Sons, 1978. [3] Biler et al.; The 8π-problem for radially symmetric solutions of a chemotaxis model in the plane, Mathematical Methods in the Applied Sciences, 2006 29, 1563–1583. [4] A. Blanchet, J. Dolbeault, B. Perthame; Two-dimensional Keller-Segel model: Optimal crit- ical mass and qualitative properties of the solutions, Electronic Journal of Differential Equa- tions, 2006 (2006) No. 44, 1–33. [5] L. Corrias, B. Perthame, H. Zaag; Global solutions of some chemotaxis and angiogenesis systems in high space dimensions, Milan Journal of Mathematics, 72 (2004), 611–616. [6] H. Dong, D. Kim; On lp-estimates for elliptic and parabolic equations with ap weights, Trans- missions of the American Mathematical Society, Volume 307, Number 7, (2018), 5081–5130. [7] E.F. Keller, L.A. Segel; Initiation of Slime Mold Aggregation Viewed as an Instability Journal of Theoretical Biology, (1970) 26, 399–415. [8] H. Kozono, Y. Sugiyama; Keller-Segel system of parabolic-parabolic type with initial data in weak Ln/2(Rn) and its application to self-similar solutions, Indiana University Mathematics Journal, 57 (2008) 1467–1500. [9] H. Kozono, Y. Sugiyama, T. Wachi; Existence and uniqueness theorem on mild solutions to the Keller-Segel system in the scaling invariant space, Journal of Differential Equations 252 (2012), 1213–1228. [10] H. Kozono, M. Yamazaki; Uniqueness criterion of weak solutions to the stationary Navier- Stokes equations in exterior domains, Nonlinear Analysis, 38 (1999), 959–970. [11] N. V. Krylov; Rubio de Francia extrapolation theorem and related topics in the theory of elliptic and parabolic equations. A survey, Algebra i Analiz, 2020, Volume 32, Issue 3, 5–38. [12] T. Phan; Well-Posedness for the Navier-Stokes equations in critical mixed-norm Lebesgue spaces, Journal of Evolution Equations (2019), 1–24. [13] T. Phan, T. Robertson; On Masuda uniqueness theorem for Leray–Hopf weak solutions in mixed-norm spaces, European Journal of Mechanics - B/Fluids 90 (2021), 18–28. Timothy Robertson Department of Mathematics, University of Tennessee, Knoxville, USA Email address: trober41@vols.utk.edu 1. Introduction 2. Preliminary inequalities and estimates in mixed-norm spaces 3. Proof of Theorem ?? 4. Proof of uniqueness 5. Appendix References