id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
ecj-10037	Sartori, Simone; Brilli, Valentina; Lanzi, Cecilia; Pratticò, Luca; Sarcoli, Elisabetta; Di Milia, Maria Grazia; Gambassi, Francesco; Mannaioni, Guido	Acute intoxication following massive bupropion sniffing: A case report	2021	3	.pdf	application/pdf	2181	148	47	Discussion This case of intranasal bupropion misuse shared only some of the most common clinical features of a classical bupropion inges- tion overdose (considering comparable amounts of medication).14 Therapeutic daily doses for bupropion are usually up to 300 mg/day15 reaching peak concentration after 1.5 hours and 3-5 hours for immediate or modified-release formulations, respectively.16 Half-life is about 21 hours in chronic users and it can be even longer for the presence of active metabolites.14 Therapeutic win- dow is considered between 5 to 100 ng/mL.17 Bupropion misuse might rapidly become a concerning issue and monitoring by healthcare professionals is needed.	cache/ecj-10037.pdf	txt/ecj-10037.txt