id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
ecj-13110	Venuso, Luigi; Ricciardi, Francesco; Del Prete, Antonio; Virgolesi, Michele; Pucciarelli, Gianluca; Langella, Luigi; Rea, Teresa	Efficacy of intranasal naloxone compared to other administration routes in prehospital opioid overdose management and beyond: a narrative review	2025	7	.pdf	application/pdf	5425	317	46	In the study by McDonald et al.,17 three main objectives were pursued: i) to describe the pharmacokinetic profile of intranasal naloxone; ii) to compare early systemic exposure between intranasal and intramuscular naloxone; and iii) to estimate the bioavailability of intranasal naloxone. Intranasal naloxone at 1 mg, 2 mg, and 4 mg achieved peak plasma concentrations of approximately 0.95 ng/mL, 1.72 ng/mL, and 3.5 ng/mL, respectively, within 15-30 minutes, consistently surpassing those achieved with intramuscular naloxone in terms of total exposure.	cache/ecj-13110.pdf	txt/ecj-13110.txt