id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
ecj-1636	Nicosia, Francesco; Savelli, Francesco; Lari, Federico; Di Luzio, Raffaella; Giostra, Fabrizio; Di Battista, Nicola	The determinants for oxygen delivery: is increased fraction of inspired oxygen always crucial?	2014	4	.pdf	application/pdf	3288	203	56	However, its hemodynamic effects and the consequences on tissue oxygenation are still not entirely clear.4 Methods and Results In this paper we analized the data originally collected from Leach,6 and subsequently ana- lyzed by Huang,7 as a pretext to try to provide an explanation of the physiopathological effects of O2 administration on tissue oxygena- tion; and to frame in a pathophysiological con- text the revisions that are involving several guidelines on the administration of O2. In addition, O2 increases the production of tumor necrosis factor alpha (TNF�) and iso- prostane and the activation of caspase 3 and 9.31 There are clinical observations that show that serious hypoxemia is tolerated without evidence of inadequate tissue oxygenation.32,33 In a study of patients with exacerbation of COPD with severe hypoxemia (<40 mmHg) there was no evidence of dysoxia, even with levels of PaO2 equal to 22 mmHg.34 In patients at rest, even the most severe form of hypox- emia from lung failure in itself does not involve generalized tissue anaerobiosis.23 Directions and guidelines Therefore, O2 administration is used for many disorders causing hypoxia.	cache/ecj-1636.pdf	txt/ecj-1636.txt