id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
ecj-2241	Monti, Manuel; Stefanecchia, Lucia; Fusco Moffa, Igino; Fioriti, Luciano; Filippucci, Manolo; Vincentelli, Giovanni Maria; Borgognoni, Francesco	Management of the patient with sepsis in emergency department: a new alternative protocol	2014	4	.pdf	application/pdf	2799	161	55	Point: should lactate clearance be substituted for central venous oxygen saturation as goals of early severe sepsis and septic shock therapy? Introduction The progression of sepsis towards an unfa- vorable outcome depends mainly on delayed diagnosis and treatment, on the virulence of the pathogen and on the immune status of the patient.1 Jones has recently defined sepsis as a complex puzzle, where the host response to the infection is characterized by different reac- tions such as inflammation, endothelial dys- function, alterations to the coagulation-fibri- nolysis system and others.2 The course of the disease can lead to severe sepsis, multiple organs failure, hypotension, and septic shock.3 The hospitalization rate of people with a principal diagnosis of septicemia or sepsis more than doubled from 2000 through 2008, increasing from 11.6 to 24.0 per 10,000 people with a prevalence of gram-negative infections.4 Patterns of infecting organisms were similar to those in previous studies, with predominant organisms being Staphylococcus aureus (20.5%), Pseudomonas species (19.9%), Enterobacteriacae (mainly E. coli, 16.0%), and fungi (19%).5 The early goal-directed therapy (EGDT) is often underused partly due to the difficulty in invasive procedures.	cache/ecj-2241.pdf	txt/ecj-2241.txt