id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
ecj-8119	Riccardi, Alessandro; Spinola, Beatrice; Minuto, Pierangela; Licenziato, Marco; Ghiglione, Valeria; Lerza, Roberto	Efficacy and tolerability of fixed association of oxycodone and naloxone in elderly patients with ribs fracture: An 18-month retrospective study	2019	4	.pdf	application/pdf	3133	169	59	When physicians decided to administer NSAIDs or Acetaminophen, due to a lower NPS value reported by patients, we demonstrated a slight increase in NPS at 24 hours, after an initial reduction, and these data confirm that such analgesic could be inappropriate for treatment of a painful condition like rib fractures.2,3 The conse- quences of oligoanalgesia in the elderly are well-known and docu- mented,21,22 and opiophobia (especially in older patients) lead to over-prescription of NSAIDs,6 even when they are contraindicated or ineffective,3-5 with increased renal and gastrointestinal toxicity.27 Acetaminophen has been recommended by most societies and by the World Health Organization as the first-line agent in the treat- ment of mild-to-moderate pain, given its tolerability, nevertheless its poor analgesic efficacy in severe pain limits its utilization.28 The efficacy of oxycodone-naloxone are well documented, even in eld- erly people.23,24 Our study confirms also the good tolerability of the association of oxycodone-naloxone, as seen in literature:16,23,26 [page 79] Efficacy and tolerability of fixed association of oxycodone and naloxone in elderly patients with ribs fracture: An 18-month retrospective study Alessandro Riccardi, Beatrice Spinola, Pierangela Minuto, Marco Licenziato, Valeria Ghiglione, Roberto Lerza Emergency Department, San Paolo Hospital, Savona, Italy Non -co mmerc ial us e o nly [page 80]	cache/ecj-8119.pdf	txt/ecj-8119.txt