id	sid	tid	token	lemma	pos
ecj-10810	1	1	hrev_master	hrev_master	NOUN
ecj-10810	2	1	[	[	X
ecj-10810	2	2	page	page	NOUN
ecj-10810	2	3	10	10	NUM
ecj-10810	2	4	]	]	PUNCT
ecj-10810	3	1	[	[	X
ecj-10810	3	2	emergency	emergency	NOUN
ecj-10810	3	3	care	care	NOUN
ecj-10810	3	4	journal	journal	NOUN
ecj-10810	3	5	2023	2023	NUM
ecj-10810	3	6	;	;	PUNCT
ecj-10810	3	7	19:10810	19:10810	X
ecj-10810	3	8	]	]	X
ecj-10810	3	9	emergency	emergency	NOUN
ecj-10810	3	10	care	care	NOUN
ecj-10810	3	11	journal	journal	PROPN
ecj-10810	3	12	2023	2023	NUM
ecj-10810	3	13	;	;	PUNCT
ecj-10810	3	14	volume	volume	NOUN
ecj-10810	3	15	19:10810	19:10810	NUM
ecj-10810	3	16	abstract	abstract	ADJ
ecj-10810	3	17	much	much	ADJ
ecj-10810	3	18	research	research	NOUN
ecj-10810	3	19	,	,	PUNCT
ecj-10810	3	20	both	both	CCONJ
ecj-10810	3	21	pathophysiological	pathophysiological	ADJ
ecj-10810	3	22	and	and	CCONJ
ecj-10810	3	23	clinical	clinical	ADJ
ecj-10810	3	24	,	,	PUNCT
ecj-10810	3	25	has	have	AUX
ecj-10810	3	26	been	be	AUX
ecj-10810	3	27	produced	produce	VERB
ecj-10810	3	28	on	on	ADP
ecj-10810	3	29	septic	septic	ADJ
ecj-10810	3	30	shock	shock	NOUN
ecj-10810	3	31	during	during	ADP
ecj-10810	3	32	the	the	DET
ecj-10810	3	33	last	last	ADJ
ecj-10810	3	34	20	20	NUM
ecj-10810	3	35	years	year	NOUN
ecj-10810	3	36	.	.	PUNCT
ecj-10810	4	1	nevertheless	nevertheless	ADV
ecj-10810	4	2	,	,	PUNCT
ecj-10810	4	3	many	many	ADJ
ecj-10810	4	4	aspects	aspect	NOUN
ecj-10810	4	5	of	of	ADP
ecj-10810	4	6	treatment	treatment	NOUN
ecj-10810	4	7	are	be	AUX
ecj-10810	4	8	still	still	ADV
ecj-10810	4	9	controversial	controversial	ADJ
ecj-10810	4	10	,	,	PUNCT
ecj-10810	4	11	among	among	ADP
ecj-10810	4	12	these	these	DET
ecj-10810	4	13	the	the	DET
ecj-10810	4	14	approach	approach	NOUN
ecj-10810	4	15	to	to	ADP
ecj-10810	4	16	the	the	DET
ecj-10810	4	17	administration	administration	NOUN
ecj-10810	4	18	of	of	ADP
ecj-10810	4	19	fluids	fluid	NOUN
ecj-10810	4	20	and	and	CCONJ
ecj-10810	4	21	vasopressors	vasopressor	NOUN
ecj-10810	4	22	.	.	PUNCT
ecj-10810	5	1	moreover	moreover	ADV
ecj-10810	5	2	,	,	PUNCT
ecj-10810	5	3	most	most	ADV
ecj-10810	5	4	clinical	clinical	ADJ
ecj-10810	5	5	research	research	NOUN
ecj-10810	5	6	on	on	ADP
ecj-10810	5	7	septic	septic	ADJ
ecj-10810	5	8	shock	shock	NOUN
ecj-10810	5	9	was	be	AUX
ecj-10810	5	10	produced	produce	VERB
ecj-10810	5	11	in	in	ADP
ecj-10810	5	12	the	the	DET
ecj-10810	5	13	icu	icu	PROPN
ecj-10810	5	14	setting	set	VERB
ecj-10810	5	15	on	on	ADP
ecj-10810	5	16	mechanically	mechanically	ADV
ecj-10810	5	17	ventilated	ventilate	VERB
ecj-10810	5	18	and	and	CCONJ
ecj-10810	5	19	invasively	invasively	ADV
ecj-10810	5	20	monitored	monitored	ADJ
ecj-10810	5	21	patients	patient	NOUN
ecj-10810	5	22	,	,	PUNCT
ecj-10810	5	23	a	a	DET
ecj-10810	5	24	situation	situation	NOUN
ecj-10810	5	25	hardly	hardly	ADV
ecj-10810	5	26	comparable	comparable	ADJ
ecj-10810	5	27	to	to	ADP
ecj-10810	5	28	that	that	PRON
ecj-10810	5	29	of	of	ADP
ecj-10810	5	30	most	most	ADJ
ecj-10810	5	31	emergency	emergency	NOUN
ecj-10810	5	32	rooms	room	NOUN
ecj-10810	5	33	throughout	throughout	ADP
ecj-10810	5	34	the	the	DET
ecj-10810	5	35	world	world	NOUN
ecj-10810	5	36	.	.	PUNCT
ecj-10810	6	1	in	in	ADP
ecj-10810	6	2	this	this	DET
ecj-10810	6	3	non	non	ADJ
ecj-10810	6	4	-	-	ADJ
ecj-10810	6	5	systematic	systematic	ADJ
ecj-10810	6	6	review	review	NOUN
ecj-10810	6	7	,	,	PUNCT
ecj-10810	6	8	the	the	DET
ecj-10810	6	9	basic	basic	ADJ
ecj-10810	6	10	pathophysiological	pathophysiological	ADJ
ecj-10810	6	11	concepts	concept	NOUN
ecj-10810	6	12	and	and	CCONJ
ecj-10810	6	13	the	the	DET
ecj-10810	6	14	most	most	ADV
ecj-10810	6	15	important	important	ADJ
ecj-10810	6	16	messages	message	NOUN
ecj-10810	6	17	from	from	ADP
ecj-10810	6	18	clinical	clinical	ADJ
ecj-10810	6	19	studies	study	NOUN
ecj-10810	6	20	will	will	AUX
ecj-10810	6	21	be	be	AUX
ecj-10810	6	22	summarized	summarize	VERB
ecj-10810	6	23	,	,	PUNCT
ecj-10810	6	24	with	with	ADP
ecj-10810	6	25	the	the	DET
ecj-10810	6	26	aim	aim	NOUN
ecj-10810	6	27	to	to	PART
ecj-10810	6	28	identify	identify	VERB
ecj-10810	6	29	the	the	DET
ecj-10810	6	30	baseline	baseline	NOUN
ecj-10810	6	31	skills	skill	NOUN
ecj-10810	6	32	and	and	CCONJ
ecj-10810	6	33	knowledge	knowledge	NOUN
ecj-10810	6	34	necessary	necessary	ADJ
ecj-10810	6	35	for	for	ADP
ecj-10810	6	36	a	a	DET
ecj-10810	6	37	first	first	ADJ
ecj-10810	6	38	approach	approach	NOUN
ecj-10810	6	39	to	to	ADP
ecj-10810	6	40	septic	septic	ADJ
ecj-10810	6	41	shock	shock	NOUN
ecj-10810	6	42	patients	patient	NOUN
ecj-10810	6	43	in	in	ADP
ecj-10810	6	44	the	the	DET
ecj-10810	6	45	emergency	emergency	NOUN
ecj-10810	6	46	room	room	NOUN
ecj-10810	6	47	.	.	PUNCT
ecj-10810	7	1	introduction	introduction	NOUN
ecj-10810	7	2	knowledge	knowledge	NOUN
ecj-10810	7	3	of	of	ADP
ecj-10810	7	4	pathophysiology	pathophysiology	NOUN
ecj-10810	7	5	and	and	CCONJ
ecj-10810	7	6	clinical	clinical	ADJ
ecj-10810	7	7	trials	trial	NOUN
ecj-10810	7	8	are	be	AUX
ecj-10810	7	9	the	the	DET
ecj-10810	7	10	landmarks	landmark	NOUN
ecj-10810	7	11	of	of	ADP
ecj-10810	7	12	modern	modern	ADJ
ecj-10810	7	13	medical	medical	ADJ
ecj-10810	7	14	practice	practice	NOUN
ecj-10810	7	15	.	.	PUNCT
ecj-10810	8	1	unfortunately	unfortunately	ADV
ecj-10810	8	2	,	,	PUNCT
ecj-10810	8	3	pathophysiological	pathophysiological	ADJ
ecj-10810	8	4	knowledge	knowledge	NOUN
ecj-10810	8	5	is	be	AUX
ecj-10810	8	6	often	often	ADV
ecj-10810	8	7	incomplete	incomplete	ADJ
ecj-10810	8	8	,	,	PUNCT
ecj-10810	8	9	and	and	CCONJ
ecj-10810	8	10	the	the	DET
ecj-10810	8	11	results	result	NOUN
ecj-10810	8	12	of	of	ADP
ecj-10810	8	13	clinical	clinical	ADJ
ecj-10810	8	14	trials	trial	NOUN
ecj-10810	8	15	may	may	AUX
ecj-10810	8	16	be	be	AUX
ecj-10810	8	17	at	at	ADP
ecj-10810	8	18	odds	odd	NOUN
ecj-10810	8	19	with	with	ADP
ecj-10810	8	20	each	each	DET
ecj-10810	8	21	other	other	ADJ
ecj-10810	8	22	.	.	PUNCT
ecj-10810	9	1	the	the	DET
ecj-10810	9	2	practicing	practice	VERB
ecj-10810	9	3	physician	physician	NOUN
ecj-10810	9	4	must	must	AUX
ecj-10810	9	5	therefore	therefore	ADV
ecj-10810	9	6	strive	strive	VERB
ecj-10810	9	7	to	to	PART
ecj-10810	9	8	critically	critically	ADV
ecj-10810	9	9	use	use	VERB
ecj-10810	9	10	the	the	DET
ecj-10810	9	11	information	information	NOUN
ecj-10810	9	12	derived	derive	VERB
ecj-10810	9	13	from	from	ADP
ecj-10810	9	14	these	these	DET
ecj-10810	9	15	two	two	NUM
ecj-10810	9	16	branches	branch	NOUN
ecj-10810	9	17	of	of	ADP
ecj-10810	9	18	research	research	NOUN
ecj-10810	9	19	to	to	PART
ecj-10810	9	20	respond	respond	VERB
ecj-10810	9	21	as	as	ADV
ecj-10810	9	22	well	well	ADV
ecj-10810	9	23	as	as	ADP
ecj-10810	9	24	possible	possible	ADJ
ecj-10810	9	25	to	to	ADP
ecj-10810	9	26	each	each	DET
ecj-10810	9	27	patient	patient	NOUN
ecj-10810	9	28	’s	’s	PART
ecj-10810	9	29	needs	need	NOUN
ecj-10810	9	30	.	.	PUNCT
ecj-10810	10	1	many	many	ADJ
ecj-10810	10	2	important	important	ADJ
ecj-10810	10	3	studies	study	NOUN
ecj-10810	10	4	,	,	PUNCT
ecj-10810	10	5	both	both	CCONJ
ecj-10810	10	6	pathophysiological	pathophysiological	ADJ
ecj-10810	10	7	and	and	CCONJ
ecj-10810	10	8	clinical	clinical	ADJ
ecj-10810	10	9	,	,	PUNCT
ecj-10810	10	10	have	have	AUX
ecj-10810	10	11	been	be	AUX
ecj-10810	10	12	conducted	conduct	VERB
ecj-10810	10	13	over	over	ADP
ecj-10810	10	14	the	the	DET
ecj-10810	10	15	past	past	ADJ
ecj-10810	10	16	twenty	twenty	NUM
ecj-10810	10	17	years	year	NOUN
ecj-10810	10	18	.	.	PUNCT
ecj-10810	11	1	consequently	consequently	ADV
ecj-10810	11	2	,	,	PUNCT
ecj-10810	11	3	the	the	DET
ecj-10810	11	4	approach	approach	NOUN
ecj-10810	11	5	to	to	ADP
ecj-10810	11	6	patients	patient	NOUN
ecj-10810	11	7	in	in	ADP
ecj-10810	11	8	septic	septic	ADJ
ecj-10810	11	9	shock	shock	NOUN
ecj-10810	11	10	has	have	AUX
ecj-10810	11	11	improved	improve	VERB
ecj-10810	11	12	and	and	CCONJ
ecj-10810	11	13	mortality	mortality	NOUN
ecj-10810	11	14	has	have	VERB
ecj-10810	11	15	fallen,1	fallen,1	NOUN
ecj-10810	11	16	yet	yet	ADV
ecj-10810	11	17	controversies	controversy	NOUN
ecj-10810	11	18	are	be	AUX
ecj-10810	11	19	still	still	ADV
ecj-10810	11	20	open	open	ADJ
ecj-10810	11	21	as	as	ADP
ecj-10810	11	22	many	many	ADJ
ecj-10810	11	23	important	important	ADJ
ecj-10810	11	24	questions	question	NOUN
ecj-10810	11	25	need	need	VERB
ecj-10810	11	26	answers	answer	NOUN
ecj-10810	11	27	and	and	CCONJ
ecj-10810	11	28	additional	additional	ADJ
ecj-10810	11	29	research.2	research.2	NOUN
ecj-10810	11	30	moreover	moreover	ADV
ecj-10810	11	31	,	,	PUNCT
ecj-10810	11	32	most	most	ADV
ecj-10810	11	33	clinical	clinical	ADJ
ecj-10810	11	34	research	research	NOUN
ecj-10810	11	35	on	on	ADP
ecj-10810	11	36	septic	septic	ADJ
ecj-10810	11	37	shock	shock	NOUN
ecj-10810	11	38	was	be	AUX
ecj-10810	11	39	produced	produce	VERB
ecj-10810	11	40	in	in	ADP
ecj-10810	11	41	the	the	DET
ecj-10810	11	42	icu	icu	PROPN
ecj-10810	11	43	setting	set	VERB
ecj-10810	11	44	on	on	ADP
ecj-10810	11	45	mechanically	mechanically	ADV
ecj-10810	11	46	ventilated	ventilate	VERB
ecj-10810	11	47	and	and	CCONJ
ecj-10810	11	48	invasively	invasively	ADV
ecj-10810	11	49	monitored	monitored	ADJ
ecj-10810	11	50	patients	patient	NOUN
ecj-10810	11	51	,	,	PUNCT
ecj-10810	11	52	a	a	DET
ecj-10810	11	53	situation	situation	NOUN
ecj-10810	11	54	hardly	hardly	ADV
ecj-10810	11	55	comparable	comparable	ADJ
ecj-10810	11	56	to	to	ADP
ecj-10810	11	57	that	that	PRON
ecj-10810	11	58	of	of	ADP
ecj-10810	11	59	most	most	ADJ
ecj-10810	11	60	emergency	emergency	NOUN
ecj-10810	11	61	departments	department	NOUN
ecj-10810	11	62	(	(	PUNCT
ecj-10810	11	63	ed	ed	NOUN
ecj-10810	11	64	)	)	PUNCT
ecj-10810	11	65	throughout	throughout	ADP
ecj-10810	11	66	the	the	DET
ecj-10810	11	67	world	world	NOUN
ecj-10810	11	68	.	.	PUNCT
ecj-10810	12	1	this	this	DET
ecj-10810	12	2	article	article	NOUN
ecj-10810	12	3	summarizes	summarize	VERB
ecj-10810	12	4	the	the	DET
ecj-10810	12	5	most	most	ADV
ecj-10810	12	6	important	important	ADJ
ecj-10810	12	7	aspects	aspect	NOUN
ecj-10810	12	8	of	of	ADP
ecj-10810	12	9	the	the	DET
ecj-10810	12	10	administration	administration	NOUN
ecj-10810	12	11	of	of	ADP
ecj-10810	12	12	fluids	fluid	NOUN
ecj-10810	12	13	and	and	CCONJ
ecj-10810	12	14	vasopressors	vasopressor	NOUN
ecj-10810	12	15	,	,	PUNCT
ecj-10810	12	16	based	base	VERB
ecj-10810	12	17	on	on	ADP
ecj-10810	12	18	a	a	DET
ecj-10810	12	19	personal	personal	ADJ
ecj-10810	12	20	selection	selection	NOUN
ecj-10810	12	21	from	from	ADP
ecj-10810	12	22	the	the	DET
ecj-10810	12	23	endless	endless	ADJ
ecj-10810	12	24	literature	literature	NOUN
ecj-10810	12	25	on	on	ADP
ecj-10810	12	26	the	the	DET
ecj-10810	12	27	topic	topic	NOUN
ecj-10810	12	28	,	,	PUNCT
ecj-10810	12	29	to	to	PART
ecj-10810	12	30	propose	propose	VERB
ecj-10810	12	31	as	as	ADP
ecj-10810	12	32	a	a	DET
ecj-10810	12	33	conclusion	conclusion	NOUN
ecj-10810	12	34	some	some	DET
ecj-10810	12	35	operational	operational	ADJ
ecj-10810	12	36	suggestions	suggestion	NOUN
ecj-10810	12	37	for	for	ADP
ecj-10810	12	38	daily	daily	ADJ
ecj-10810	12	39	medical	medical	ADJ
ecj-10810	12	40	practice	practice	NOUN
ecj-10810	12	41	in	in	ADP
ecj-10810	12	42	the	the	DET
ecj-10810	12	43	ed	ed	NOUN
ecj-10810	12	44	.	.	PUNCT
ecj-10810	13	1	macro	macro	NOUN
ecj-10810	13	2	and	and	CCONJ
ecj-10810	13	3	microcirculation	microcirculation	NOUN
ecj-10810	13	4	in	in	ADP
ecj-10810	13	5	septic	septic	ADJ
ecj-10810	13	6	shock	shock	NOUN
ecj-10810	13	7	sepsis	sepsis	NOUN
ecj-10810	13	8	is	be	AUX
ecj-10810	13	9	a	a	DET
ecj-10810	13	10	life	life	NOUN
ecj-10810	13	11	-	-	PUNCT
ecj-10810	13	12	threatening	threaten	VERB
ecj-10810	13	13	organ	organ	NOUN
ecj-10810	13	14	dysfunction	dysfunction	NOUN
ecj-10810	13	15	caused	cause	VERB
ecj-10810	13	16	by	by	ADP
ecj-10810	13	17	a	a	DET
ecj-10810	13	18	dysregulated	dysregulated	ADJ
ecj-10810	13	19	host	host	NOUN
ecj-10810	13	20	response	response	NOUN
ecj-10810	13	21	to	to	ADP
ecj-10810	13	22	infection	infection	NOUN
ecj-10810	13	23	.	.	PUNCT
ecj-10810	14	1	from	from	ADP
ecj-10810	14	2	the	the	DET
ecj-10810	14	3	perspective	perspective	NOUN
ecj-10810	14	4	of	of	ADP
ecj-10810	14	5	macrocirculation	macrocirculation	NOUN
ecj-10810	14	6	,	,	PUNCT
ecj-10810	14	7	septic	septic	ADJ
ecj-10810	14	8	shock	shock	NOUN
ecj-10810	14	9	is	be	AUX
ecj-10810	14	10	a	a	DET
ecj-10810	14	11	distributive	distributive	ADJ
ecj-10810	14	12	shock	shock	NOUN
ecj-10810	14	13	characterized	characterize	VERB
ecj-10810	14	14	by	by	ADP
ecj-10810	14	15	increased	increase	VERB
ecj-10810	14	16	venous	venous	ADJ
ecj-10810	14	17	capacitance	capacitance	NOUN
ecj-10810	14	18	and	and	CCONJ
ecj-10810	14	19	decreased	decrease	VERB
ecj-10810	14	20	systemic	systemic	ADJ
ecj-10810	14	21	vascular	vascular	ADJ
ecj-10810	14	22	resistance	resistance	NOUN
ecj-10810	14	23	(	(	PUNCT
ecj-10810	14	24	svr	svr	PROPN
ecj-10810	14	25	)	)	PUNCT
ecj-10810	14	26	.	.	PUNCT
ecj-10810	15	1	the	the	DET
ecj-10810	15	2	reduction	reduction	NOUN
ecj-10810	15	3	in	in	ADP
ecj-10810	15	4	parietal	parietal	ADJ
ecj-10810	15	5	tone	tone	NOUN
ecj-10810	15	6	and	and	CCONJ
ecj-10810	15	7	increased	increase	VERB
ecj-10810	15	8	capacitance	capacitance	NOUN
ecj-10810	15	9	of	of	ADP
ecj-10810	15	10	the	the	DET
ecj-10810	15	11	venous	venous	ADJ
ecj-10810	15	12	circulation	circulation	NOUN
ecj-10810	15	13	has	have	VERB
ecj-10810	15	14	the	the	DET
ecj-10810	15	15	most	most	ADV
ecj-10810	15	16	significant	significant	ADJ
ecj-10810	15	17	hemodynamic	hemodynamic	NOUN
ecj-10810	15	18	effect,3,4	effect,3,4	ADJ
ecj-10810	15	19	because	because	SCONJ
ecj-10810	15	20	about	about	ADV
ecj-10810	15	21	75	75	NUM
ecj-10810	15	22	%	%	NOUN
ecj-10810	15	23	of	of	ADP
ecj-10810	15	24	the	the	DET
ecj-10810	15	25	blood	blood	NOUN
ecj-10810	15	26	volume	volume	NOUN
ecj-10810	15	27	circulates	circulate	VERB
ecj-10810	15	28	in	in	ADP
ecj-10810	15	29	the	the	DET
ecj-10810	15	30	veins	vein	NOUN
ecj-10810	15	31	.	.	PUNCT
ecj-10810	16	1	as	as	SCONJ
ecj-10810	16	2	the	the	DET
ecj-10810	16	3	disease	disease	NOUN
ecj-10810	16	4	advances	advance	VERB
ecj-10810	16	5	,	,	PUNCT
ecj-10810	16	6	almost	almost	ADV
ecj-10810	16	7	half	half	DET
ecj-10810	16	8	the	the	DET
ecj-10810	16	9	patients	patient	NOUN
ecj-10810	16	10	with	with	ADP
ecj-10810	16	11	septic	septic	ADJ
ecj-10810	16	12	shock	shock	NOUN
ecj-10810	16	13	develop	develop	VERB
ecj-10810	16	14	a	a	DET
ecj-10810	16	15	cardiomyopathy5,6	cardiomyopathy5,6	NOUN
ecj-10810	16	16	which	which	PRON
ecj-10810	16	17	can	can	AUX
ecj-10810	16	18	significantly	significantly	ADV
ecj-10810	16	19	impair	impair	VERB
ecj-10810	16	20	ventricular	ventricular	ADJ
ecj-10810	16	21	function	function	NOUN
ecj-10810	16	22	,	,	PUNCT
ecj-10810	16	23	affecting	affect	VERB
ecj-10810	16	24	the	the	DET
ecj-10810	16	25	cardiac	cardiac	ADJ
ecj-10810	16	26	output	output	NOUN
ecj-10810	16	27	(	(	PUNCT
ecj-10810	16	28	co	co	NOUN
ecj-10810	16	29	)	)	PUNCT
ecj-10810	16	30	.	.	PUNCT
ecj-10810	17	1	turning	turn	VERB
ecj-10810	17	2	to	to	ADP
ecj-10810	17	3	microcirculation	microcirculation	NOUN
ecj-10810	17	4	,	,	PUNCT
ecj-10810	17	5	a	a	DET
ecj-10810	17	6	complex	complex	ADJ
ecj-10810	17	7	interaction	interaction	NOUN
ecj-10810	17	8	between	between	ADP
ecj-10810	17	9	pro	pro	ADJ
ecj-10810	17	10	and	and	CCONJ
ecj-10810	17	11	anti	anti	ADJ
ecj-10810	17	12	-	-	ADJ
ecj-10810	17	13	inflammatory	inflammatory	ADJ
ecj-10810	17	14	and	and	CCONJ
ecj-10810	17	15	coagulative	coagulative	ADJ
ecj-10810	17	16	phenomena7	phenomena7	NOUN
ecj-10810	17	17	produces	produce	VERB
ecj-10810	17	18	endothelial	endothelial	ADJ
ecj-10810	17	19	dysfunction	dysfunction	NOUN
ecj-10810	17	20	,	,	PUNCT
ecj-10810	17	21	glycocalyx	glycocalyx	PROPN
ecj-10810	17	22	degradation	degradation	NOUN
ecj-10810	17	23	,	,	PUNCT
ecj-10810	17	24	altered	alter	VERB
ecj-10810	17	25	blood	blood	NOUN
ecj-10810	17	26	cell	cell	NOUN
ecj-10810	17	27	rheology	rheology	NOUN
ecj-10810	17	28	,	,	PUNCT
ecj-10810	17	29	and	and	CCONJ
ecj-10810	17	30	imbalance	imbalance	NOUN
ecj-10810	17	31	between	between	ADP
ecj-10810	17	32	the	the	DET
ecj-10810	17	33	levels	level	NOUN
ecj-10810	17	34	of	of	ADP
ecj-10810	17	35	vasodilating	vasodilate	VERB
ecj-10810	17	36	and	and	CCONJ
ecj-10810	17	37	vasoconstricting	vasoconstricte	VERB
ecj-10810	17	38	substances	substance	NOUN
ecj-10810	17	39	,	,	PUNCT
ecj-10810	17	40	altering	alter	VERB
ecj-10810	17	41	the	the	DET
ecj-10810	17	42	matching	matching	NOUN
ecj-10810	17	43	of	of	ADP
ecj-10810	17	44	blood	blood	NOUN
ecj-10810	17	45	flow	flow	NOUN
ecj-10810	17	46	to	to	ADP
ecj-10810	17	47	tissue	tissue	NOUN
ecj-10810	17	48	demand.8	demand.8	NOUN
ecj-10810	17	49	it	it	PRON
ecj-10810	17	50	has	have	AUX
ecj-10810	17	51	been	be	AUX
ecj-10810	17	52	demonstrated	demonstrate	VERB
ecj-10810	17	53	that	that	SCONJ
ecj-10810	17	54	sepsis	sepsis	NOUN
ecj-10810	17	55	is	be	AUX
ecj-10810	17	56	associated	associate	VERB
ecj-10810	17	57	with	with	ADP
ecj-10810	17	58	reduced	reduced	ADJ
ecj-10810	17	59	microvascular	microvascular	ADJ
ecj-10810	17	60	density	density	NOUN
ecj-10810	17	61	,	,	PUNCT
ecj-10810	17	62	an	an	DET
ecj-10810	17	63	increased	increase	VERB
ecj-10810	17	64	number	number	NOUN
ecj-10810	17	65	of	of	ADP
ecj-10810	17	66	nonperfused	nonperfuse	VERB
ecj-10810	17	67	small	small	ADJ
ecj-10810	17	68	vessels	vessel	NOUN
ecj-10810	17	69	,	,	PUNCT
ecj-10810	17	70	and	and	CCONJ
ecj-10810	17	71	heterogeneity	heterogeneity	NOUN
ecj-10810	17	72	among	among	ADP
ecj-10810	17	73	microcirculatory	microcirculatory	ADJ
ecj-10810	17	74	areas	area	NOUN
ecj-10810	17	75	.	.	PUNCT
ecj-10810	18	1	the	the	DET
ecj-10810	18	2	direction	direction	NOUN
ecj-10810	18	3	,	,	PUNCT
ecj-10810	18	4	extent	extent	NOUN
ecj-10810	18	5	,	,	PUNCT
ecj-10810	18	6	and	and	CCONJ
ecj-10810	18	7	duration	duration	NOUN
ecj-10810	18	8	of	of	ADP
ecj-10810	18	9	these	these	DET
ecj-10810	18	10	reactions	reaction	NOUN
ecj-10810	18	11	are	be	AUX
ecj-10810	18	12	determined	determine	VERB
ecj-10810	18	13	by	by	ADP
ecj-10810	18	14	factors	factor	NOUN
ecj-10810	18	15	related	relate	VERB
ecj-10810	18	16	to	to	ADP
ecj-10810	18	17	the	the	DET
ecj-10810	18	18	host	host	NOUN
ecj-10810	18	19	(	(	PUNCT
ecj-10810	18	20	genetics	genetics	NOUN
ecj-10810	18	21	,	,	PUNCT
ecj-10810	18	22	age	age	NOUN
ecj-10810	18	23	,	,	PUNCT
ecj-10810	18	24	co	co	NOUN
ecj-10810	18	25	-	-	NOUN
ecj-10810	18	26	pathology	pathology	NOUN
ecj-10810	18	27	,	,	PUNCT
ecj-10810	18	28	immunodepression	immunodepression	NOUN
ecj-10810	18	29	)	)	PUNCT
ecj-10810	18	30	and	and	CCONJ
ecj-10810	18	31	the	the	DET
ecj-10810	18	32	pathogen	pathogen	NOUN
ecj-10810	18	33	(	(	PUNCT
ecj-10810	18	34	microbial	microbial	ADJ
ecj-10810	18	35	load	load	NOUN
ecj-10810	18	36	and	and	CCONJ
ecj-10810	18	37	virulence	virulence	NOUN
ecj-10810	18	38	)	)	PUNCT
ecj-10810	18	39	.	.	PUNCT
ecj-10810	19	1	macrocirculatory	macrocirculatory	ADJ
ecj-10810	19	2	status	status	NOUN
ecj-10810	19	3	can	can	AUX
ecj-10810	19	4	be	be	AUX
ecj-10810	19	5	assessed	assess	VERB
ecj-10810	19	6	by	by	ADP
ecj-10810	19	7	the	the	DET
ecj-10810	19	8	direct	direct	ADJ
ecj-10810	19	9	or	or	CCONJ
ecj-10810	19	10	indirect	indirect	ADJ
ecj-10810	19	11	measurement	measurement	NOUN
ecj-10810	19	12	of	of	ADP
ecj-10810	19	13	parameters	parameter	NOUN
ecj-10810	19	14	such	such	ADJ
ecj-10810	19	15	as	as	ADP
ecj-10810	19	16	stroke	stroke	NOUN
ecj-10810	19	17	volume	volume	NOUN
ecj-10810	19	18	(	(	PUNCT
ecj-10810	19	19	sv	sv	PROPN
ecj-10810	19	20	)	)	PUNCT
ecj-10810	19	21	,	,	PUNCT
ecj-10810	19	22	central	central	ADJ
ecj-10810	19	23	venous	venous	ADJ
ecj-10810	19	24	pressure	pressure	NOUN
ecj-10810	19	25	(	(	PUNCT
ecj-10810	19	26	cvp	cvp	NOUN
ecj-10810	19	27	)	)	PUNCT
ecj-10810	19	28	,	,	PUNCT
ecj-10810	19	29	and	and	CCONJ
ecj-10810	19	30	blood	blood	NOUN
ecj-10810	19	31	pressure	pressure	NOUN
ecj-10810	19	32	(	(	PUNCT
ecj-10810	19	33	bp).9	bp).9	VERB
ecj-10810	19	34	however	however	ADV
ecj-10810	19	35	,	,	PUNCT
ecj-10810	19	36	cvp	cvp	PROPN
ecj-10810	19	37	and	and	CCONJ
ecj-10810	19	38	bp	bp	PROPN
ecj-10810	19	39	have	have	VERB
ecj-10810	19	40	only	only	ADV
ecj-10810	19	41	a	a	DET
ecj-10810	19	42	low	low	ADJ
ecj-10810	19	43	to	to	PART
ecj-10810	19	44	moderate	moderate	ADJ
ecj-10810	19	45	predictive	predictive	ADJ
ecj-10810	19	46	correspondence	correspondence	NOUN
ecj-10810	19	47	:	:	PUNCT
ecj-10810	19	48	daniele	daniele	PROPN
ecj-10810	19	49	coen	coen	PROPN
ecj-10810	19	50	,	,	PUNCT
ecj-10810	19	51	emergency	emergency	NOUN
ecj-10810	19	52	department	department	NOUN
ecj-10810	19	53	,	,	PUNCT
ecj-10810	19	54	grande	grande	X
ecj-10810	19	55	ospedale	ospedale	PROPN
ecj-10810	19	56	metropolitano	metropolitano	PROPN
ecj-10810	19	57	niguarda	niguarda	PROPN
ecj-10810	19	58	,	,	PUNCT
ecj-10810	19	59	milan	milan	PROPN
ecj-10810	19	60	,	,	PUNCT
ecj-10810	19	61	italy	italy	PROPN
ecj-10810	19	62	.	.	PUNCT
ecj-10810	20	1	tel	tel	PROPN
ecj-10810	20	2	.	.	PUNCT
ecj-10810	20	3	:	:	PUNCT
ecj-10810	21	1	+39.339.8954101	+39.339.8954101	X
ecj-10810	21	2	.	.	PUNCT
ecj-10810	22	1	e	e	X
ecj-10810	22	2	-	-	NOUN
ecj-10810	22	3	mail	mail	NOUN
ecj-10810	22	4	:	:	PUNCT
ecj-10810	23	1	dacoen53@gmail.com	dacoen53@gmail.com	X
ecj-10810	23	2	key	key	ADJ
ecj-10810	23	3	words	word	NOUN
ecj-10810	23	4	:	:	PUNCT
ecj-10810	23	5	fluid	fluid	ADJ
ecj-10810	23	6	resuscitation	resuscitation	NOUN
ecj-10810	23	7	;	;	PUNCT
ecj-10810	23	8	vasopressors	vasopressor	NOUN
ecj-10810	23	9	;	;	PUNCT
ecj-10810	23	10	septic	septic	ADJ
ecj-10810	23	11	shock	shock	NOUN
ecj-10810	23	12	;	;	PUNCT
ecj-10810	23	13	preload	preload	NOUN
ecj-10810	23	14	;	;	PUNCT
ecj-10810	23	15	stressed	stress	VERB
ecj-10810	23	16	volume	volume	NOUN
ecj-10810	23	17	;	;	PUNCT
ecj-10810	23	18	emergency	emergency	NOUN
ecj-10810	23	19	department	department	NOUN
ecj-10810	23	20	.	.	PUNCT
ecj-10810	24	1	financial	financial	ADJ
ecj-10810	24	2	support	support	NOUN
ecj-10810	24	3	:	:	PUNCT
ecj-10810	24	4	this	this	DET
ecj-10810	24	5	research	research	NOUN
ecj-10810	24	6	did	do	AUX
ecj-10810	24	7	not	not	PART
ecj-10810	24	8	receive	receive	VERB
ecj-10810	24	9	any	any	DET
ecj-10810	24	10	specific	specific	ADJ
ecj-10810	24	11	grant	grant	NOUN
ecj-10810	24	12	from	from	ADP
ecj-10810	24	13	funding	fund	VERB
ecj-10810	24	14	agencies	agency	NOUN
ecj-10810	24	15	in	in	ADP
ecj-10810	24	16	the	the	DET
ecj-10810	24	17	public	public	ADJ
ecj-10810	24	18	,	,	PUNCT
ecj-10810	24	19	commercial	commercial	ADJ
ecj-10810	24	20	,	,	PUNCT
ecj-10810	24	21	or	or	CCONJ
ecj-10810	24	22	not	not	PART
ecj-10810	24	23	-	-	PUNCT
ecj-10810	24	24	for	for	ADP
ecj-10810	24	25	-	-	PUNCT
ecj-10810	24	26	profit	profit	NOUN
ecj-10810	24	27	sectors	sector	NOUN
ecj-10810	24	28	.	.	PUNCT
ecj-10810	25	1	conflict	conflict	NOUN
ecj-10810	25	2	of	of	ADP
ecj-10810	25	3	interest	interest	NOUN
ecj-10810	25	4	:	:	PUNCT
ecj-10810	25	5	the	the	DET
ecj-10810	25	6	author	author	NOUN
ecj-10810	25	7	declares	declare	VERB
ecj-10810	25	8	no	no	DET
ecj-10810	25	9	conflict	conflict	NOUN
ecj-10810	25	10	of	of	ADP
ecj-10810	25	11	interest	interest	NOUN
ecj-10810	25	12	.	.	PUNCT
ecj-10810	26	1	availability	availability	NOUN
ecj-10810	26	2	of	of	ADP
ecj-10810	26	3	data	datum	NOUN
ecj-10810	26	4	and	and	CCONJ
ecj-10810	26	5	materials	material	NOUN
ecj-10810	26	6	:	:	PUNCT
ecj-10810	26	7	all	all	DET
ecj-10810	26	8	data	datum	NOUN
ecj-10810	26	9	generated	generate	VERB
ecj-10810	26	10	or	or	CCONJ
ecj-10810	26	11	analyzed	analyze	VERB
ecj-10810	26	12	during	during	ADP
ecj-10810	26	13	this	this	DET
ecj-10810	26	14	study	study	NOUN
ecj-10810	26	15	are	be	AUX
ecj-10810	26	16	included	include	VERB
ecj-10810	26	17	in	in	ADP
ecj-10810	26	18	this	this	DET
ecj-10810	26	19	published	publish	VERB
ecj-10810	26	20	article	article	NOUN
ecj-10810	26	21	.	.	PUNCT
ecj-10810	27	1	ethics	ethic	NOUN
ecj-10810	27	2	approval	approval	NOUN
ecj-10810	27	3	and	and	CCONJ
ecj-10810	27	4	consent	consent	NOUN
ecj-10810	27	5	to	to	PART
ecj-10810	27	6	participate	participate	VERB
ecj-10810	27	7	:	:	PUNCT
ecj-10810	27	8	not	not	PART
ecj-10810	27	9	applicable	applicable	ADJ
ecj-10810	27	10	.	.	PUNCT
ecj-10810	28	1	informed	informed	ADJ
ecj-10810	28	2	consent	consent	NOUN
ecj-10810	28	3	:	:	PUNCT
ecj-10810	28	4	not	not	PART
ecj-10810	28	5	applicable	applicable	ADJ
ecj-10810	28	6	.	.	PUNCT
ecj-10810	29	1	received	receive	VERB
ecj-10810	29	2	for	for	ADP
ecj-10810	29	3	publication	publication	NOUN
ecj-10810	29	4	:	:	PUNCT
ecj-10810	29	5	22	22	NUM
ecj-10810	29	6	august	august	PROPN
ecj-10810	29	7	2022	2022	NUM
ecj-10810	29	8	.	.	PUNCT
ecj-10810	30	1	revision	revision	NOUN
ecj-10810	30	2	received	receive	VERB
ecj-10810	30	3	:	:	PUNCT
ecj-10810	30	4	5	5	NUM
ecj-10810	30	5	february	february	NOUN
ecj-10810	30	6	2022	2022	NUM
ecj-10810	30	7	.	.	PUNCT
ecj-10810	31	1	accepted	accept	VERB
ecj-10810	31	2	for	for	ADP
ecj-10810	31	3	publication	publication	NOUN
ecj-10810	31	4	:	:	PUNCT
ecj-10810	31	5	14	14	NUM
ecj-10810	31	6	february	february	NOUN
ecj-10810	31	7	2022	2022	NUM
ecj-10810	31	8	.	.	PUNCT
ecj-10810	32	1	this	this	DET
ecj-10810	32	2	work	work	NOUN
ecj-10810	32	3	is	be	AUX
ecj-10810	32	4	licensed	license	VERB
ecj-10810	32	5	under	under	ADP
ecj-10810	32	6	a	a	DET
ecj-10810	32	7	creative	creative	ADJ
ecj-10810	32	8	commons	common	NOUN
ecj-10810	32	9	attribution	attribution	NOUN
ecj-10810	32	10	4.0	4.0	NUM
ecj-10810	32	11	license	license	NOUN
ecj-10810	32	12	(	(	PUNCT
ecj-10810	32	13	by	by	ADP
ecj-10810	32	14	-	-	PUNCT
ecj-10810	32	15	nc	nc	PROPN
ecj-10810	32	16	4.0	4.0	NUM
ecj-10810	32	17	)	)	PUNCT
ecj-10810	32	18	.	.	PUNCT
ecj-10810	33	1	©	©	PROPN
ecj-10810	33	2	copyright	copyright	NOUN
ecj-10810	33	3	:	:	PUNCT
ecj-10810	33	4	the	the	DET
ecj-10810	33	5	author(s	author(s	PROPN
ecj-10810	33	6	)	)	PUNCT
ecj-10810	33	7	,	,	PUNCT
ecj-10810	33	8	2023	2023	NUM
ecj-10810	33	9	licensee	licensee	NOUN
ecj-10810	33	10	pagepress	pagepress	NOUN
ecj-10810	33	11	,	,	PUNCT
ecj-10810	33	12	italy	italy	PROPN
ecj-10810	33	13	emergency	emergency	PROPN
ecj-10810	33	14	care	care	PROPN
ecj-10810	33	15	journal	journal	PROPN
ecj-10810	33	16	2023	2023	NUM
ecj-10810	33	17	;	;	PUNCT
ecj-10810	33	18	19:10810	19:10810	NUM
ecj-10810	33	19	doi:10.4081	doi:10.4081	NOUN
ecj-10810	33	20	/	/	SYM
ecj-10810	33	21	ecj.2023.10810	ecj.2023.10810	PROPN
ecj-10810	33	22	publisher	publisher	NOUN
ecj-10810	33	23	's	's	PART
ecj-10810	33	24	note	note	NOUN
ecj-10810	33	25	:	:	PUNCT
ecj-10810	33	26	all	all	DET
ecj-10810	33	27	claims	claim	NOUN
ecj-10810	33	28	expressed	express	VERB
ecj-10810	33	29	in	in	ADP
ecj-10810	33	30	this	this	DET
ecj-10810	33	31	article	article	NOUN
ecj-10810	33	32	are	be	AUX
ecj-10810	33	33	solely	solely	ADV
ecj-10810	33	34	those	those	PRON
ecj-10810	33	35	of	of	ADP
ecj-10810	33	36	the	the	DET
ecj-10810	33	37	authors	author	NOUN
ecj-10810	33	38	and	and	CCONJ
ecj-10810	33	39	do	do	AUX
ecj-10810	33	40	not	not	PART
ecj-10810	33	41	necessarily	necessarily	ADV
ecj-10810	33	42	represent	represent	VERB
ecj-10810	33	43	those	those	PRON
ecj-10810	33	44	of	of	ADP
ecj-10810	33	45	their	their	PRON
ecj-10810	33	46	affiliated	affiliated	ADJ
ecj-10810	33	47	organizations	organization	NOUN
ecj-10810	33	48	,	,	PUNCT
ecj-10810	33	49	or	or	CCONJ
ecj-10810	33	50	those	those	PRON
ecj-10810	33	51	of	of	ADP
ecj-10810	33	52	the	the	DET
ecj-10810	33	53	publisher	publisher	NOUN
ecj-10810	33	54	,	,	PUNCT
ecj-10810	33	55	the	the	DET
ecj-10810	33	56	editors	editor	NOUN
ecj-10810	33	57	and	and	CCONJ
ecj-10810	33	58	the	the	DET
ecj-10810	33	59	reviewers	reviewer	NOUN
ecj-10810	33	60	.	.	PUNCT
ecj-10810	34	1	any	any	DET
ecj-10810	34	2	product	product	NOUN
ecj-10810	34	3	that	that	PRON
ecj-10810	34	4	may	may	AUX
ecj-10810	34	5	be	be	AUX
ecj-10810	34	6	evaluated	evaluate	VERB
ecj-10810	34	7	in	in	ADP
ecj-10810	34	8	this	this	DET
ecj-10810	34	9	article	article	NOUN
ecj-10810	34	10	or	or	CCONJ
ecj-10810	34	11	claim	claim	NOUN
ecj-10810	34	12	that	that	PRON
ecj-10810	34	13	may	may	AUX
ecj-10810	34	14	be	be	AUX
ecj-10810	34	15	made	make	VERB
ecj-10810	34	16	by	by	ADP
ecj-10810	34	17	its	its	PRON
ecj-10810	34	18	manufacturer	manufacturer	NOUN
ecj-10810	34	19	is	be	AUX
ecj-10810	34	20	not	not	PART
ecj-10810	34	21	guaranteed	guarantee	VERB
ecj-10810	34	22	or	or	CCONJ
ecj-10810	34	23	endorsed	endorse	VERB
ecj-10810	34	24	by	by	ADP
ecj-10810	34	25	the	the	DET
ecj-10810	34	26	publisher	publisher	NOUN
ecj-10810	34	27	.	.	PUNCT
ecj-10810	35	1	fluids	fluid	NOUN
ecj-10810	35	2	and	and	CCONJ
ecj-10810	35	3	vasopressors	vasopressor	NOUN
ecj-10810	35	4	in	in	ADP
ecj-10810	35	5	septic	septic	ADJ
ecj-10810	35	6	shock	shock	NOUN
ecj-10810	35	7	:	:	PUNCT
ecj-10810	35	8	basic	basic	ADJ
ecj-10810	35	9	knowledge	knowledge	NOUN
ecj-10810	35	10	for	for	ADP
ecj-10810	35	11	a	a	DET
ecj-10810	35	12	first	first	ADJ
ecj-10810	35	13	approach	approach	NOUN
ecj-10810	35	14	in	in	ADP
ecj-10810	35	15	the	the	DET
ecj-10810	35	16	emergency	emergency	NOUN
ecj-10810	35	17	department	department	NOUN
ecj-10810	35	18	daniele	daniele	PROPN
ecj-10810	35	19	coen	coen	PROPN
ecj-10810	35	20	emergency	emergency	PROPN
ecj-10810	35	21	department	department	PROPN
ecj-10810	35	22	,	,	PUNCT
ecj-10810	35	23	grande	grande	X
ecj-10810	35	24	ospedale	ospedale	PROPN
ecj-10810	35	25	metropolitano	metropolitano	PROPN
ecj-10810	35	26	niguarda	niguarda	PROPN
ecj-10810	35	27	,	,	PUNCT
ecj-10810	35	28	milan	milan	PROPN
ecj-10810	35	29	,	,	PUNCT
ecj-10810	35	30	italy	italy	PROPN
ecj-10810	35	31	non	non	PROPN
ecj-10810	36	1	-co	-co	PROPN
ecj-10810	36	2	mmerc	mmerc	PROPN
ecj-10810	36	3	ial	ial	PROPN
ecj-10810	36	4	us	us	PROPN
ecj-10810	36	5	e	e	NOUN
ecj-10810	36	6	o	o	NOUN
ecj-10810	36	7	nly	nly	ADV
ecj-10810	36	8	power	power	NOUN
ecj-10810	36	9	in	in	ADP
ecj-10810	36	10	assessing	assess	VERB
ecj-10810	36	11	response	response	NOUN
ecj-10810	36	12	to	to	ADP
ecj-10810	36	13	treatment	treatment	NOUN
ecj-10810	36	14	,	,	PUNCT
ecj-10810	36	15	being	be	AUX
ecj-10810	36	16	reliable	reliable	ADJ
ecj-10810	36	17	only	only	ADV
ecj-10810	36	18	for	for	ADP
ecj-10810	36	19	very	very	ADV
ecj-10810	36	20	significant	significant	ADJ
ecj-10810	36	21	variations	variation	NOUN
ecj-10810	36	22	of	of	ADP
ecj-10810	36	23	their	their	PRON
ecj-10810	36	24	values.10,11	values.10,11	NOUN
ecj-10810	36	25	although	although	SCONJ
ecj-10810	36	26	sv	sv	PROPN
ecj-10810	36	27	is	be	AUX
ecj-10810	36	28	a	a	DET
ecj-10810	36	29	much	much	ADV
ecj-10810	36	30	better	well	ADJ
ecj-10810	36	31	indicator	indicator	NOUN
ecj-10810	36	32	,	,	PUNCT
ecj-10810	36	33	its	its	PRON
ecj-10810	36	34	measurement	measurement	NOUN
ecj-10810	36	35	requires	require	VERB
ecj-10810	36	36	expertise	expertise	NOUN
ecj-10810	36	37	,	,	PUNCT
ecj-10810	36	38	and	and	CCONJ
ecj-10810	36	39	its	its	PRON
ecj-10810	36	40	accuracy	accuracy	NOUN
ecj-10810	36	41	in	in	ADP
ecj-10810	36	42	predicting	predict	VERB
ecj-10810	36	43	response	response	NOUN
ecj-10810	36	44	to	to	ADP
ecj-10810	36	45	treatment	treatment	NOUN
ecj-10810	36	46	is	be	AUX
ecj-10810	36	47	higher	high	ADJ
ecj-10810	36	48	for	for	ADP
ecj-10810	36	49	sedated	sedated	ADJ
ecj-10810	36	50	and	and	CCONJ
ecj-10810	36	51	mechanically	mechanically	ADV
ecj-10810	36	52	ventilated	ventilate	VERB
ecj-10810	36	53	patients	patient	NOUN
ecj-10810	36	54	for	for	ADP
ecj-10810	36	55	whom	whom	PRON
ecj-10810	36	56	hemodynamic	hemodynamic	ADJ
ecj-10810	36	57	and	and	CCONJ
ecj-10810	36	58	respiratory	respiratory	ADJ
ecj-10810	36	59	parameters	parameter	NOUN
ecj-10810	36	60	can	can	AUX
ecj-10810	36	61	be	be	AUX
ecj-10810	36	62	more	more	ADV
ecj-10810	36	63	precisely	precisely	ADV
ecj-10810	36	64	evaluated	evaluated	ADJ
ecj-10810	36	65	.	.	PUNCT
ecj-10810	37	1	microcirculatory	microcirculatory	ADJ
ecj-10810	37	2	alterations	alteration	NOUN
ecj-10810	37	3	are	be	AUX
ecj-10810	37	4	more	more	ADV
ecj-10810	37	5	difficult	difficult	ADJ
ecj-10810	37	6	to	to	PART
ecj-10810	37	7	assess	assess	VERB
ecj-10810	37	8	because	because	SCONJ
ecj-10810	37	9	their	their	PRON
ecj-10810	37	10	assessment	assessment	NOUN
ecj-10810	37	11	relies	rely	VERB
ecj-10810	37	12	on	on	ADP
ecj-10810	37	13	semiquantitative	semiquantitative	ADJ
ecj-10810	37	14	measurements	measurement	NOUN
ecj-10810	37	15	that	that	PRON
ecj-10810	37	16	are	be	AUX
ecj-10810	37	17	difficult	difficult	ADJ
ecj-10810	37	18	to	to	PART
ecj-10810	37	19	apply	apply	VERB
ecj-10810	37	20	in	in	ADP
ecj-10810	37	21	emergency	emergency	NOUN
ecj-10810	37	22	,	,	PUNCT
ecj-10810	37	23	such	such	ADJ
ecj-10810	37	24	like	like	ADP
ecj-10810	37	25	the	the	DET
ecj-10810	37	26	direct	direct	ADJ
ecj-10810	37	27	visualization	visualization	NOUN
ecj-10810	37	28	of	of	ADP
ecj-10810	37	29	the	the	DET
ecj-10810	37	30	sublingual	sublingual	ADJ
ecj-10810	37	31	capillary	capillary	ADJ
ecj-10810	37	32	network.12	network.12	NOUN
ecj-10810	37	33	because	because	SCONJ
ecj-10810	37	34	an	an	DET
ecj-10810	37	35	improvement	improvement	NOUN
ecj-10810	37	36	in	in	ADP
ecj-10810	37	37	macrocirculation	macrocirculation	NOUN
ecj-10810	37	38	does	do	AUX
ecj-10810	37	39	not	not	PART
ecj-10810	37	40	necessarily	necessarily	ADV
ecj-10810	37	41	correspond	correspond	VERB
ecj-10810	37	42	to	to	ADP
ecj-10810	37	43	an	an	DET
ecj-10810	37	44	improvement	improvement	NOUN
ecj-10810	37	45	in	in	ADP
ecj-10810	37	46	microcirculation	microcirculation	NOUN
ecj-10810	37	47	and	and	CCONJ
ecj-10810	37	48	peripheral	peripheral	ADJ
ecj-10810	37	49	perfusion	perfusion	NOUN
ecj-10810	37	50	,	,	PUNCT
ecj-10810	37	51	the	the	DET
ecj-10810	37	52	most	most	ADV
ecj-10810	37	53	useful	useful	ADJ
ecj-10810	37	54	parameters	parameter	NOUN
ecj-10810	37	55	for	for	ADP
ecj-10810	37	56	guiding	guide	VERB
ecj-10810	37	57	therapy	therapy	NOUN
ecj-10810	37	58	remain	remain	VERB
ecj-10810	37	59	,	,	PUNCT
ecj-10810	37	60	despite	despite	SCONJ
ecj-10810	37	61	some	some	DET
ecj-10810	37	62	controversy,13	controversy,13	NOUN
ecj-10810	37	63	-	-	PUNCT
ecj-10810	37	64	15	15	NUM
ecj-10810	37	65	those	those	PRON
ecj-10810	37	66	that	that	PRON
ecj-10810	37	67	assess	assess	VERB
ecj-10810	37	68	tissue	tissue	NOUN
ecj-10810	37	69	oxygenation	oxygenation	NOUN
ecj-10810	37	70	trends	trend	NOUN
ecj-10810	37	71	(	(	PUNCT
ecj-10810	37	72	lactate	lactate	NOUN
ecj-10810	37	73	,	,	PUNCT
ecj-10810	37	74	scvo2	scvo2	NOUN
ecj-10810	37	75	,	,	PUNCT
ecj-10810	37	76	veno	veno	NOUN
ecj-10810	37	77	-	-	PUNCT
ecj-10810	37	78	arterial	arterial	NOUN
ecj-10810	37	79	pco2	pco2	NOUN
ecj-10810	37	80	gradient)16	gradient)16	NOUN
ecj-10810	37	81	in	in	ADP
ecj-10810	37	82	addition	addition	NOUN
ecj-10810	37	83	to	to	ADP
ecj-10810	37	84	clinical	clinical	ADJ
ecj-10810	37	85	parameters	parameter	NOUN
ecj-10810	37	86	(	(	PUNCT
ecj-10810	37	87	level	level	NOUN
ecj-10810	37	88	of	of	ADP
ecj-10810	37	89	consciousness	consciousness	NOUN
ecj-10810	37	90	,	,	PUNCT
ecj-10810	37	91	urinary	urinary	ADJ
ecj-10810	37	92	output	output	NOUN
ecj-10810	37	93	,	,	PUNCT
ecj-10810	37	94	and	and	CCONJ
ecj-10810	37	95	capillary	capillary	ADJ
ecj-10810	37	96	refill	refill	NOUN
ecj-10810	37	97	time	time	NOUN
ecj-10810	37	98	crt).17	crt).17	NOUN
ecj-10810	37	99	-	-	SYM
ecj-10810	37	100	18	18	NUM
ecj-10810	37	101	in	in	ADP
ecj-10810	37	102	a	a	DET
ecj-10810	37	103	recent	recent	ADJ
ecj-10810	37	104	trial	trial	NOUN
ecj-10810	37	105	,	,	PUNCT
ecj-10810	37	106	patients	patient	NOUN
ecj-10810	37	107	randomized	randomize	VERB
ecj-10810	37	108	to	to	ADP
ecj-10810	37	109	crt	crt	ADJ
ecj-10810	37	110	-	-	PUNCT
ecj-10810	37	111	guided	guide	VERB
ecj-10810	37	112	resuscitation	resuscitation	NOUN
ecj-10810	37	113	fared	fare	VERB
ecj-10810	37	114	as	as	ADV
ecj-10810	37	115	well	well	ADV
ecj-10810	37	116	or	or	CCONJ
ecj-10810	37	117	better	well	ADJ
ecj-10810	37	118	compared	compare	VERB
ecj-10810	37	119	with	with	ADP
ecj-10810	37	120	patients	patient	NOUN
ecj-10810	37	121	randomized	randomize	VERB
ecj-10810	37	122	to	to	ADP
ecj-10810	37	123	lactate	lactate	NOUN
ecj-10810	37	124	-	-	PUNCT
ecj-10810	37	125	guided	guide	VERB
ecj-10810	37	126	therapy.19	therapy.19	NOUN
ecj-10810	37	127	in	in	ADP
ecj-10810	37	128	conclusion	conclusion	NOUN
ecj-10810	37	129	,	,	PUNCT
ecj-10810	37	130	no	no	DET
ecj-10810	37	131	single	single	ADJ
ecj-10810	37	132	measurement	measurement	NOUN
ecj-10810	37	133	best	well	ADV
ecj-10810	37	134	identifies	identify	VERB
ecj-10810	37	135	the	the	DET
ecj-10810	37	136	severity	severity	NOUN
ecj-10810	37	137	of	of	ADP
ecj-10810	37	138	the	the	DET
ecj-10810	37	139	shock	shock	NOUN
ecj-10810	37	140	,	,	PUNCT
ecj-10810	37	141	nor	nor	CCONJ
ecj-10810	37	142	how	how	SCONJ
ecj-10810	37	143	an	an	DET
ecj-10810	37	144	individual	individual	ADJ
ecj-10810	37	145	patient	patient	NOUN
ecj-10810	37	146	will	will	AUX
ecj-10810	37	147	respond	respond	VERB
ecj-10810	37	148	to	to	ADP
ecj-10810	37	149	fluid	fluid	ADJ
ecj-10810	37	150	administration	administration	NOUN
ecj-10810	37	151	and	and	CCONJ
ecj-10810	37	152	other	other	ADJ
ecj-10810	37	153	treatments	treatment	NOUN
ecj-10810	37	154	.	.	PUNCT
ecj-10810	38	1	a	a	DET
ecj-10810	38	2	combination	combination	NOUN
ecj-10810	38	3	of	of	ADP
ecj-10810	38	4	clinical	clinical	ADJ
ecj-10810	38	5	signs	sign	NOUN
ecj-10810	38	6	,	,	PUNCT
ecj-10810	38	7	hemodynamic	hemodynamic	ADJ
ecj-10810	38	8	parameters	parameter	NOUN
ecj-10810	38	9	,	,	PUNCT
ecj-10810	38	10	and	and	CCONJ
ecj-10810	38	11	laboratory	laboratory	NOUN
ecj-10810	38	12	tests	test	NOUN
ecj-10810	38	13	will	will	AUX
ecj-10810	38	14	continue	continue	VERB
ecj-10810	38	15	to	to	PART
ecj-10810	38	16	be	be	AUX
ecj-10810	38	17	used	use	VERB
ecj-10810	38	18	by	by	ADP
ecj-10810	38	19	physicians	physician	NOUN
ecj-10810	38	20	according	accord	VERB
ecj-10810	38	21	to	to	ADP
ecj-10810	38	22	their	their	PRON
ecj-10810	38	23	level	level	NOUN
ecj-10810	38	24	of	of	ADP
ecj-10810	38	25	expertise	expertise	NOUN
ecj-10810	38	26	and	and	CCONJ
ecj-10810	38	27	the	the	DET
ecj-10810	38	28	availability	availability	NOUN
ecj-10810	38	29	of	of	ADP
ecj-10810	38	30	diagnostic	diagnostic	ADJ
ecj-10810	38	31	instruments	instrument	NOUN
ecj-10810	38	32	.	.	PUNCT
ecj-10810	39	1	the	the	DET
ecj-10810	39	2	determinants	determinant	NOUN
ecj-10810	39	3	of	of	ADP
ecj-10810	39	4	cardiac	cardiac	ADJ
ecj-10810	39	5	output	output	NOUN
ecj-10810	39	6	cardiac	cardiac	ADJ
ecj-10810	39	7	output	output	NOUN
ecj-10810	39	8	is	be	AUX
ecj-10810	39	9	determined	determine	VERB
ecj-10810	39	10	by	by	ADP
ecj-10810	39	11	preload	preload	NOUN
ecj-10810	39	12	,	,	PUNCT
ecj-10810	39	13	inotropism	inotropism	NOUN
ecj-10810	39	14	,	,	PUNCT
ecj-10810	39	15	and	and	CCONJ
ecj-10810	39	16	afterload	afterload	NOUN
ecj-10810	39	17	.	.	PUNCT
ecj-10810	40	1	inotropism	inotropism	NOUN
ecj-10810	40	2	and	and	CCONJ
ecj-10810	40	3	preload	preload	NOUN
ecj-10810	40	4	are	be	AUX
ecj-10810	40	5	directly	directly	ADV
ecj-10810	40	6	related	relate	VERB
ecj-10810	40	7	to	to	PART
ecj-10810	40	8	co	co	VERB
ecj-10810	40	9	,	,	PUNCT
ecj-10810	40	10	while	while	SCONJ
ecj-10810	40	11	afterload	afterload	NOUN
ecj-10810	40	12	has	have	VERB
ecj-10810	40	13	an	an	DET
ecj-10810	40	14	inverse	inverse	NOUN
ecj-10810	40	15	relation	relation	NOUN
ecj-10810	40	16	.	.	PUNCT
ecj-10810	41	1	therefore	therefore	ADV
ecj-10810	41	2	,	,	PUNCT
ecj-10810	41	3	when	when	SCONJ
ecj-10810	41	4	bp	bp	PROPN
ecj-10810	41	5	falls	fall	VERB
ecj-10810	41	6	in	in	ADP
ecj-10810	41	7	front	front	NOUN
ecj-10810	41	8	of	of	ADP
ecj-10810	41	9	no	no	DET
ecj-10810	41	10	change	change	NOUN
ecj-10810	41	11	(	(	PUNCT
ecj-10810	41	12	or	or	CCONJ
ecj-10810	41	13	an	an	DET
ecj-10810	41	14	increase	increase	NOUN
ecj-10810	41	15	)	)	PUNCT
ecj-10810	41	16	in	in	ADP
ecj-10810	41	17	co	co	NOUN
ecj-10810	41	18	,	,	PUNCT
ecj-10810	41	19	the	the	DET
ecj-10810	41	20	primary	primary	ADJ
ecj-10810	41	21	problem	problem	NOUN
ecj-10810	41	22	must	must	AUX
ecj-10810	41	23	be	be	AUX
ecj-10810	41	24	a	a	DET
ecj-10810	41	25	decrease	decrease	NOUN
ecj-10810	41	26	in	in	ADP
ecj-10810	41	27	svr	svr	PROPN
ecj-10810	41	28	.	.	PUNCT
ecj-10810	42	1	on	on	ADP
ecj-10810	42	2	the	the	DET
ecj-10810	42	3	contrary	contrary	NOUN
ecj-10810	42	4	,	,	PUNCT
ecj-10810	42	5	when	when	SCONJ
ecj-10810	42	6	bp	bp	PROPN
ecj-10810	42	7	falls	fall	VERB
ecj-10810	42	8	and	and	CCONJ
ecj-10810	42	9	co	co	NOUN
ecj-10810	42	10	falls	fall	VERB
ecj-10810	42	11	too	too	ADV
ecj-10810	42	12	,	,	PUNCT
ecj-10810	42	13	the	the	DET
ecj-10810	42	14	primary	primary	ADJ
ecj-10810	42	15	problem	problem	NOUN
ecj-10810	42	16	stays	stay	VERB
ecj-10810	42	17	with	with	ADP
ecj-10810	42	18	co	co	NOUN
ecj-10810	42	19	and	and	CCONJ
ecj-10810	42	20	the	the	DET
ecj-10810	42	21	next	next	ADJ
ecj-10810	42	22	question	question	NOUN
ecj-10810	42	23	is	be	AUX
ecj-10810	42	24	whether	whether	SCONJ
ecj-10810	42	25	co	co	PRON
ecj-10810	42	26	fell	fall	VERB
ecj-10810	42	27	because	because	SCONJ
ecj-10810	42	28	of	of	ADP
ecj-10810	42	29	a	a	DET
ecj-10810	42	30	decrease	decrease	NOUN
ecj-10810	42	31	in	in	ADP
ecj-10810	42	32	inotropism	inotropism	NOUN
ecj-10810	42	33	or	or	CCONJ
ecj-10810	42	34	in	in	ADP
ecj-10810	42	35	venous	venous	ADJ
ecj-10810	42	36	return.3,20	return.3,20	NOUN
ecj-10810	42	37	it	it	PRON
ecj-10810	42	38	is	be	AUX
ecj-10810	42	39	unanimously	unanimously	ADV
ecj-10810	42	40	agreed	agree	VERB
ecj-10810	42	41	that	that	SCONJ
ecj-10810	42	42	the	the	DET
ecj-10810	42	43	administration	administration	NOUN
ecj-10810	42	44	of	of	ADP
ecj-10810	42	45	fluids	fluid	NOUN
ecj-10810	42	46	and	and	CCONJ
ecj-10810	42	47	vasopressors	vasopressor	NOUN
ecj-10810	42	48	has	have	VERB
ecj-10810	42	49	the	the	DET
ecj-10810	42	50	main	main	ADJ
ecj-10810	42	51	clinical	clinical	ADJ
ecj-10810	42	52	goal	goal	NOUN
ecj-10810	42	53	of	of	ADP
ecj-10810	42	54	enhancing	enhance	VERB
ecj-10810	42	55	co	co	NOUN
ecj-10810	42	56	through	through	ADP
ecj-10810	42	57	an	an	DET
ecj-10810	42	58	increase	increase	NOUN
ecj-10810	42	59	of	of	ADP
ecj-10810	42	60	preload	preload	NOUN
ecj-10810	42	61	.	.	PUNCT
ecj-10810	43	1	when	when	SCONJ
ecj-10810	43	2	this	this	PRON
ecj-10810	43	3	is	be	AUX
ecj-10810	43	4	not	not	PART
ecj-10810	43	5	the	the	DET
ecj-10810	43	6	case	case	NOUN
ecj-10810	43	7	,	,	PUNCT
ecj-10810	43	8	they	they	PRON
ecj-10810	43	9	are	be	AUX
ecj-10810	43	10	at	at	ADP
ecj-10810	43	11	best	well	ADV
ecj-10810	43	12	useless	useless	ADJ
ecj-10810	43	13	and	and	CCONJ
ecj-10810	43	14	can	can	AUX
ecj-10810	43	15	be	be	AUX
ecj-10810	43	16	detrimental	detrimental	ADJ
ecj-10810	43	17	.	.	PUNCT
ecj-10810	44	1	the	the	DET
ecj-10810	44	2	return	return	NOUN
ecj-10810	44	3	of	of	ADP
ecj-10810	44	4	systemic	systemic	ADJ
ecj-10810	44	5	venous	venous	ADJ
ecj-10810	44	6	blood	blood	NOUN
ecj-10810	44	7	to	to	ADP
ecj-10810	44	8	the	the	DET
ecj-10810	44	9	heart	heart	NOUN
ecj-10810	44	10	is	be	AUX
ecj-10810	44	11	determined	determine	VERB
ecj-10810	44	12	by	by	ADP
ecj-10810	44	13	the	the	DET
ecj-10810	44	14	difference	difference	NOUN
ecj-10810	44	15	between	between	ADP
ecj-10810	44	16	mean	mean	ADJ
ecj-10810	44	17	venous	venous	ADJ
ecj-10810	44	18	filling	filling	NOUN
ecj-10810	44	19	pressure	pressure	NOUN
ecj-10810	44	20	(	(	PUNCT
ecj-10810	44	21	msfp	msfp	ADJ
ecj-10810	44	22	)	)	PUNCT
ecj-10810	44	23	and	and	CCONJ
ecj-10810	44	24	central	central	ADJ
ecj-10810	44	25	venous	venous	ADJ
ecj-10810	44	26	pressure	pressure	NOUN
ecj-10810	44	27	(	(	PUNCT
ecj-10810	44	28	cvp).3,12	cvp).3,12	PROPN
ecj-10810	44	29	msfp	msfp	PROPN
ecj-10810	44	30	is	be	AUX
ecj-10810	44	31	the	the	DET
ecj-10810	44	32	pressure	pressure	NOUN
ecj-10810	44	33	that	that	PRON
ecj-10810	44	34	would	would	AUX
ecj-10810	44	35	be	be	AUX
ecj-10810	44	36	measured	measure	VERB
ecj-10810	44	37	at	at	ADP
ecj-10810	44	38	each	each	DET
ecj-10810	44	39	point	point	NOUN
ecj-10810	44	40	in	in	ADP
ecj-10810	44	41	the	the	DET
ecj-10810	44	42	circulatory	circulatory	ADJ
ecj-10810	44	43	system	system	NOUN
ecj-10810	44	44	(	(	PUNCT
ecj-10810	44	45	excluding	exclude	VERB
ecj-10810	44	46	the	the	DET
ecj-10810	44	47	heart	heart	NOUN
ecj-10810	44	48	and	and	CCONJ
ecj-10810	44	49	pulmonary	pulmonary	ADJ
ecj-10810	44	50	circulation	circulation	NOUN
ecj-10810	44	51	)	)	PUNCT
ecj-10810	44	52	if	if	SCONJ
ecj-10810	44	53	the	the	DET
ecj-10810	44	54	heart	heart	NOUN
ecj-10810	44	55	stopped	stop	VERB
ecj-10810	44	56	and	and	CCONJ
ecj-10810	44	57	blood	blood	NOUN
ecj-10810	44	58	was	be	AUX
ecj-10810	44	59	redistributed	redistribute	VERB
ecj-10810	44	60	instantaneously	instantaneously	ADV
ecj-10810	44	61	so	so	SCONJ
ecj-10810	44	62	that	that	SCONJ
ecj-10810	44	63	the	the	DET
ecj-10810	44	64	pressure	pressure	NOUN
ecj-10810	44	65	was	be	AUX
ecj-10810	44	66	the	the	DET
ecj-10810	44	67	same	same	ADJ
ecj-10810	44	68	at	at	ADP
ecj-10810	44	69	each	each	DET
ecj-10810	44	70	point	point	NOUN
ecj-10810	44	71	.	.	PUNCT
ecj-10810	45	1	mean	mean	VERB
ecj-10810	45	2	venous	venous	ADJ
ecj-10810	45	3	filling	filling	NOUN
ecj-10810	45	4	pressure	pressure	NOUN
ecj-10810	45	5	tends	tend	VERB
ecj-10810	45	6	to	to	PART
ecj-10810	45	7	remain	remain	VERB
ecj-10810	45	8	constant	constant	ADJ
ecj-10810	45	9	even	even	ADV
ecj-10810	45	10	for	for	ADP
ecj-10810	45	11	large	large	ADJ
ecj-10810	45	12	changes	change	NOUN
ecj-10810	45	13	in	in	ADP
ecj-10810	45	14	co	co	NOUN
ecj-10810	45	15	,	,	PUNCT
ecj-10810	45	16	is	be	AUX
ecj-10810	45	17	not	not	PART
ecj-10810	45	18	clinically	clinically	ADV
ecj-10810	45	19	measurable	measurable	ADJ
ecj-10810	45	20	,	,	PUNCT
ecj-10810	45	21	and	and	CCONJ
ecj-10810	45	22	is	be	AUX
ecj-10810	45	23	estimated	estimate	VERB
ecj-10810	45	24	to	to	PART
ecj-10810	45	25	be	be	AUX
ecj-10810	45	26	between	between	ADP
ecj-10810	45	27	7	7	NUM
ecj-10810	45	28	and	and	CCONJ
ecj-10810	45	29	12	12	NUM
ecj-10810	45	30	mmhg	mmhg	NOUN
ecj-10810	45	31	in	in	ADP
ecj-10810	45	32	humans.3	humans.3	ADJ
ecj-10810	45	33	msfp	msfp	ADJ
ecj-10810	45	34	is	be	AUX
ecj-10810	45	35	determined	determine	VERB
ecj-10810	45	36	by	by	ADP
ecj-10810	45	37	intravascular	intravascular	ADJ
ecj-10810	45	38	volume	volume	NOUN
ecj-10810	45	39	and	and	CCONJ
ecj-10810	45	40	venous	venous	ADJ
ecj-10810	45	41	tone	tone	NOUN
ecj-10810	45	42	.	.	PUNCT
ecj-10810	46	1	intravascular	intravascular	ADJ
ecj-10810	46	2	volume	volume	NOUN
ecj-10810	46	3	can	can	AUX
ecj-10810	46	4	be	be	AUX
ecj-10810	46	5	considered	consider	VERB
ecj-10810	46	6	as	as	ADP
ecj-10810	46	7	consisting	consist	VERB
ecj-10810	46	8	of	of	ADP
ecj-10810	46	9	two	two	NUM
ecj-10810	46	10	parts	part	NOUN
ecj-10810	46	11	.	.	PUNCT
ecj-10810	47	1	the	the	DET
ecj-10810	47	2	first	first	ADJ
ecj-10810	47	3	one	one	NUM
ecj-10810	47	4	,	,	PUNCT
ecj-10810	47	5	which	which	PRON
ecj-10810	47	6	represents	represent	VERB
ecj-10810	47	7	about	about	ADP
ecj-10810	47	8	85	85	NUM
ecj-10810	47	9	%	%	NOUN
ecj-10810	47	10	of	of	ADP
ecj-10810	47	11	the	the	DET
ecj-10810	47	12	total	total	ADJ
ecj-10810	47	13	volume	volume	NOUN
ecj-10810	47	14	(	(	PUNCT
ecj-10810	47	15	vt	vt	NOUN
ecj-10810	47	16	)	)	PUNCT
ecj-10810	47	17	exerts	exert	VERB
ecj-10810	47	18	no	no	DET
ecj-10810	47	19	pressure	pressure	NOUN
ecj-10810	47	20	on	on	ADP
ecj-10810	47	21	the	the	DET
ecj-10810	47	22	vascular	vascular	ADJ
ecj-10810	47	23	walls	wall	NOUN
ecj-10810	47	24	and	and	CCONJ
ecj-10810	47	25	theoretically	theoretically	ADV
ecj-10810	47	26	represents	represent	VERB
ecj-10810	47	27	the	the	DET
ecj-10810	47	28	volume	volume	NOUN
ecj-10810	47	29	that	that	PRON
ecj-10810	47	30	corresponds	correspond	VERB
ecj-10810	47	31	to	to	ADP
ecj-10810	47	32	an	an	DET
ecj-10810	47	33	msfp=0	msfp=0	PROPN
ecj-10810	47	34	.	.	PROPN
ecj-10810	48	1	for	for	ADP
ecj-10810	48	2	this	this	DET
ecj-10810	48	3	reason	reason	NOUN
ecj-10810	48	4	,	,	PUNCT
ecj-10810	48	5	it	it	PRON
ecj-10810	48	6	is	be	AUX
ecj-10810	48	7	referred	refer	VERB
ecj-10810	48	8	to	to	ADP
ecj-10810	48	9	as	as	ADP
ecj-10810	48	10	the	the	DET
ecj-10810	48	11	unstressed	unstressed	ADJ
ecj-10810	48	12	volume	volume	NOUN
ecj-10810	48	13	(	(	PUNCT
ecj-10810	48	14	vu	vu	NOUN
ecj-10810	48	15	)	)	PUNCT
ecj-10810	48	16	.	.	PUNCT
ecj-10810	49	1	the	the	DET
ecj-10810	49	2	second	second	ADJ
ecj-10810	49	3	one	one	NOUN
ecj-10810	49	4	,	,	PUNCT
ecj-10810	49	5	representing	represent	VERB
ecj-10810	49	6	the	the	DET
ecj-10810	49	7	remaining	remain	VERB
ecj-10810	49	8	15	15	NUM
ecj-10810	49	9	%	%	NOUN
ecj-10810	49	10	of	of	ADP
ecj-10810	49	11	vt	vt	PROPN
ecj-10810	49	12	,	,	PUNCT
ecj-10810	49	13	exerts	exert	VERB
ecj-10810	49	14	the	the	DET
ecj-10810	49	15	hydrostatic	hydrostatic	ADJ
ecj-10810	49	16	pressure	pressure	NOUN
ecj-10810	49	17	responsible	responsible	ADJ
ecj-10810	49	18	for	for	ADP
ecj-10810	49	19	msfp	msfp	ADJ
ecj-10810	49	20	and	and	CCONJ
ecj-10810	49	21	is	be	AUX
ecj-10810	49	22	consequently	consequently	ADV
ecj-10810	49	23	referred	refer	VERB
ecj-10810	49	24	to	to	ADP
ecj-10810	49	25	as	as	ADP
ecj-10810	49	26	the	the	DET
ecj-10810	49	27	stressed	stressed	ADJ
ecj-10810	49	28	volume	volume	NOUN
ecj-10810	49	29	(	(	PUNCT
ecj-10810	49	30	vs).21	vs).21	NOUN
ecj-10810	49	31	as	as	SCONJ
ecj-10810	49	32	we	we	PRON
ecj-10810	49	33	will	will	AUX
ecj-10810	49	34	see	see	VERB
ecj-10810	49	35	later	later	ADV
ecj-10810	49	36	,	,	PUNCT
ecj-10810	49	37	fluids	fluid	NOUN
ecj-10810	49	38	increase	increase	VERB
ecj-10810	49	39	vs	vs	ADP
ecj-10810	49	40	replenishing	replenish	VERB
ecj-10810	49	41	the	the	DET
ecj-10810	49	42	venous	venous	ADJ
ecj-10810	49	43	circulation	circulation	NOUN
ecj-10810	49	44	,	,	PUNCT
ecj-10810	49	45	while	while	SCONJ
ecj-10810	49	46	vasopressors	vasopressor	NOUN
ecj-10810	49	47	act	act	VERB
ecj-10810	49	48	on	on	ADP
ecj-10810	49	49	vs	vs	ADP
ecj-10810	49	50	inducing	induce	VERB
ecj-10810	49	51	venous	venous	ADJ
ecj-10810	49	52	constriction	constriction	NOUN
ecj-10810	49	53	.	.	PUNCT
ecj-10810	50	1	the	the	DET
ecj-10810	50	2	role	role	NOUN
ecj-10810	50	3	of	of	ADP
ecj-10810	50	4	blood	blood	NOUN
ecj-10810	50	5	pressure	pressure	NOUN
ecj-10810	50	6	and	and	CCONJ
ecj-10810	50	7	peripheral	peripheral	ADJ
ecj-10810	50	8	resistance	resistance	NOUN
ecj-10810	50	9	bp	bp	PROPN
ecj-10810	50	10	plays	play	VERB
ecj-10810	50	11	an	an	DET
ecj-10810	50	12	important	important	ADJ
ecj-10810	50	13	role	role	NOUN
ecj-10810	50	14	in	in	ADP
ecj-10810	50	15	determining	determine	VERB
ecj-10810	50	16	organ	organ	NOUN
ecj-10810	50	17	blood	blood	NOUN
ecj-10810	50	18	flow	flow	NOUN
ecj-10810	50	19	and	and	CCONJ
ecj-10810	50	20	therefore	therefore	ADV
ecj-10810	50	21	it	it	PRON
ecj-10810	50	22	is	be	AUX
ecj-10810	50	23	often	often	ADV
ecj-10810	50	24	used	use	VERB
ecj-10810	50	25	as	as	ADP
ecj-10810	50	26	a	a	DET
ecj-10810	50	27	surrogate	surrogate	ADJ
ecj-10810	50	28	index	index	NOUN
ecj-10810	50	29	of	of	ADP
ecj-10810	50	30	tissue	tissue	NOUN
ecj-10810	50	31	perfusion	perfusion	NOUN
ecj-10810	50	32	,	,	PUNCT
ecj-10810	50	33	although	although	SCONJ
ecj-10810	50	34	this	this	PRON
ecj-10810	50	35	can	can	AUX
ecj-10810	50	36	not	not	PART
ecj-10810	50	37	be	be	AUX
ecj-10810	50	38	considered	consider	VERB
ecj-10810	50	39	a	a	DET
ecj-10810	50	40	reliable	reliable	ADJ
ecj-10810	50	41	practice.22	practice.22	NOUN
ecj-10810	50	42	blood	blood	NOUN
ecj-10810	50	43	pressure	pressure	NOUN
ecj-10810	50	44	is	be	AUX
ecj-10810	50	45	the	the	DET
ecj-10810	50	46	product	product	NOUN
ecj-10810	50	47	of	of	ADP
ecj-10810	50	48	co	co	NOUN
ecj-10810	50	49	and	and	CCONJ
ecj-10810	50	50	systemic	systemic	ADJ
ecj-10810	50	51	vascular	vascular	ADJ
ecj-10810	50	52	resistances	resistance	NOUN
ecj-10810	50	53	,	,	PUNCT
ecj-10810	50	54	but	but	CCONJ
ecj-10810	50	55	it	it	PRON
ecj-10810	50	56	is	be	AUX
ecj-10810	50	57	the	the	DET
ecj-10810	50	58	vascular	vascular	ADJ
ecj-10810	50	59	resistances	resistance	NOUN
ecj-10810	50	60	of	of	ADP
ecj-10810	50	61	each	each	DET
ecj-10810	50	62	specific	specific	ADJ
ecj-10810	50	63	organ	organ	NOUN
ecj-10810	50	64	that	that	PRON
ecj-10810	50	65	determine	determine	VERB
ecj-10810	50	66	regional	regional	ADJ
ecj-10810	50	67	flows	flow	NOUN
ecj-10810	50	68	.	.	PUNCT
ecj-10810	51	1	thus	thus	ADV
ecj-10810	51	2	,	,	PUNCT
ecj-10810	51	3	the	the	DET
ecj-10810	51	4	distribution	distribution	NOUN
ecj-10810	51	5	of	of	ADP
ecj-10810	51	6	local	local	ADJ
ecj-10810	51	7	arterial	arterial	ADJ
ecj-10810	51	8	resistances	resistance	NOUN
ecj-10810	51	9	is	be	AUX
ecj-10810	51	10	the	the	DET
ecj-10810	51	11	major	major	ADJ
ecj-10810	51	12	determinant	determinant	NOUN
ecj-10810	51	13	of	of	ADP
ecj-10810	51	14	where	where	SCONJ
ecj-10810	51	15	blood	blood	NOUN
ecj-10810	51	16	goes	go	VERB
ecj-10810	51	17	.	.	PUNCT
ecj-10810	52	1	if	if	SCONJ
ecj-10810	52	2	the	the	DET
ecj-10810	52	3	distribution	distribution	NOUN
ecj-10810	52	4	of	of	ADP
ecj-10810	52	5	vascular	vascular	ADJ
ecj-10810	52	6	resistances	resistance	NOUN
ecj-10810	52	7	changes	change	NOUN
ecj-10810	52	8	,	,	PUNCT
ecj-10810	52	9	blood	blood	NOUN
ecj-10810	52	10	flow	flow	NOUN
ecj-10810	52	11	will	will	AUX
ecj-10810	52	12	perfuse	perfuse	VERB
ecj-10810	52	13	the	the	DET
ecj-10810	52	14	different	different	ADJ
ecj-10810	52	15	organs	organ	NOUN
ecj-10810	52	16	proportionally	proportionally	ADV
ecj-10810	52	17	to	to	ADP
ecj-10810	52	18	the	the	DET
ecj-10810	52	19	dilation	dilation	NOUN
ecj-10810	52	20	of	of	ADP
ecj-10810	52	21	their	their	PRON
ecj-10810	52	22	arteriolar	arteriolar	ADJ
ecj-10810	52	23	circulation	circulation	NOUN
ecj-10810	52	24	.	.	PUNCT
ecj-10810	53	1	the	the	DET
ecj-10810	53	2	use	use	NOUN
ecj-10810	53	3	of	of	ADP
ecj-10810	53	4	vasopressors	vasopressor	NOUN
ecj-10810	53	5	to	to	PART
ecj-10810	53	6	induce	induce	VERB
ecj-10810	53	7	constriction	constriction	NOUN
ecj-10810	53	8	in	in	ADP
ecj-10810	53	9	the	the	DET
ecj-10810	53	10	arterioles	arteriole	NOUN
ecj-10810	53	11	is	be	AUX
ecj-10810	53	12	based	base	VERB
ecj-10810	53	13	on	on	ADP
ecj-10810	53	14	the	the	DET
ecj-10810	53	15	assumption	assumption	NOUN
ecj-10810	53	16	that	that	SCONJ
ecj-10810	53	17	resistance	resistance	NOUN
ecj-10810	53	18	will	will	AUX
ecj-10810	53	19	increase	increase	VERB
ecj-10810	53	20	less	less	ADV
ecj-10810	53	21	in	in	ADP
ecj-10810	53	22	vital	vital	ADJ
ecj-10810	53	23	organs	organ	NOUN
ecj-10810	53	24	,	,	PUNCT
ecj-10810	53	25	such	such	ADJ
ecj-10810	53	26	as	as	ADP
ecj-10810	53	27	the	the	DET
ecj-10810	53	28	brain	brain	NOUN
ecj-10810	53	29	,	,	PUNCT
ecj-10810	53	30	kidney	kidney	NOUN
ecj-10810	53	31	,	,	PUNCT
ecj-10810	53	32	and	and	CCONJ
ecj-10810	53	33	heart	heart	NOUN
ecj-10810	53	34	,	,	PUNCT
ecj-10810	53	35	because	because	SCONJ
ecj-10810	53	36	of	of	ADP
ecj-10810	53	37	the	the	DET
ecj-10810	53	38	play	play	NOUN
ecj-10810	53	39	of	of	ADP
ecj-10810	53	40	local	local	ADJ
ecj-10810	53	41	neuronal	neuronal	ADJ
ecj-10810	53	42	and	and	CCONJ
ecj-10810	53	43	hormonal	hormonal	ADJ
ecj-10810	53	44	signals	signal	NOUN
ecj-10810	53	45	,	,	PUNCT
ecj-10810	53	46	thus	thus	ADV
ecj-10810	53	47	favouring	favour	VERB
ecj-10810	53	48	the	the	DET
ecj-10810	53	49	flow	flow	NOUN
ecj-10810	53	50	to	to	ADP
ecj-10810	53	51	these	these	DET
ecj-10810	53	52	districts	district	NOUN
ecj-10810	53	53	.	.	PUNCT
ecj-10810	54	1	unfortunately	unfortunately	ADV
ecj-10810	54	2	,	,	PUNCT
ecj-10810	54	3	however	however	ADV
ecj-10810	54	4	,	,	PUNCT
ecj-10810	54	5	in	in	ADP
ecj-10810	54	6	septic	septic	ADJ
ecj-10810	54	7	patients	patient	NOUN
ecj-10810	54	8	the	the	DET
ecj-10810	54	9	ability	ability	NOUN
ecj-10810	54	10	to	to	PART
ecj-10810	54	11	autoregulate	autoregulate	VERB
ecj-10810	54	12	vascular	vascular	ADJ
ecj-10810	54	13	tone	tone	NOUN
ecj-10810	54	14	is	be	AUX
ecj-10810	54	15	often	often	ADV
ecj-10810	54	16	impaired.23	impaired.23	ADJ
ecj-10810	54	17	thus	thus	ADV
ecj-10810	54	18	,	,	PUNCT
ecj-10810	54	19	it	it	PRON
ecj-10810	54	20	is	be	AUX
ecj-10810	54	21	difficult	difficult	ADJ
ecj-10810	54	22	to	to	PART
ecj-10810	54	23	foresee	foresee	VERB
ecj-10810	54	24	the	the	DET
ecj-10810	54	25	effects	effect	NOUN
ecj-10810	54	26	that	that	PRON
ecj-10810	54	27	the	the	DET
ecj-10810	54	28	administration	administration	NOUN
ecj-10810	54	29	of	of	ADP
ecj-10810	54	30	adrenergic	adrenergic	ADJ
ecj-10810	54	31	agents	agent	NOUN
ecj-10810	54	32	may	may	AUX
ecj-10810	54	33	have	have	VERB
ecj-10810	54	34	on	on	ADP
ecj-10810	54	35	regional	regional	ADJ
ecj-10810	54	36	flows	flow	NOUN
ecj-10810	54	37	.	.	PUNCT
ecj-10810	55	1	moreover	moreover	ADV
ecj-10810	55	2	,	,	PUNCT
ecj-10810	55	3	while	while	SCONJ
ecj-10810	55	4	systemic	systemic	ADJ
ecj-10810	55	5	resistances	resistance	NOUN
ecj-10810	55	6	can	can	AUX
ecj-10810	55	7	be	be	AUX
ecj-10810	55	8	calculated	calculate	VERB
ecj-10810	55	9	by	by	ADP
ecj-10810	55	10	invasive	invasive	ADJ
ecj-10810	55	11	methods	method	NOUN
ecj-10810	55	12	or	or	CCONJ
ecj-10810	55	13	derived	derive	VERB
ecj-10810	55	14	by	by	ADP
ecj-10810	55	15	sv	sv	NOUN
ecj-10810	55	16	and	and	CCONJ
ecj-10810	55	17	cvp	cvp	PROPN
ecj-10810	55	18	,	,	PUNCT
ecj-10810	55	19	regional	regional	ADJ
ecj-10810	55	20	vascular	vascular	ADJ
ecj-10810	55	21	resistances	resistance	NOUN
ecj-10810	55	22	can	can	AUX
ecj-10810	55	23	not	not	PART
ecj-10810	55	24	be	be	AUX
ecj-10810	55	25	measured	measure	VERB
ecj-10810	55	26	nor	nor	CCONJ
ecj-10810	55	27	calculated	calculate	VERB
ecj-10810	55	28	in	in	ADP
ecj-10810	55	29	the	the	DET
ecj-10810	55	30	clinical	clinical	ADJ
ecj-10810	55	31	setting	setting	NOUN
ecj-10810	55	32	.	.	PUNCT
ecj-10810	56	1	the	the	DET
ecj-10810	56	2	physiological	physiological	ADJ
ecj-10810	56	3	and	and	CCONJ
ecj-10810	56	4	pharmacological	pharmacological	ADJ
ecj-10810	56	5	basis	basis	NOUN
ecj-10810	56	6	of	of	ADP
ecj-10810	56	7	treatment	treatment	NOUN
ecj-10810	56	8	with	with	ADP
ecj-10810	56	9	fluids	fluid	NOUN
ecj-10810	56	10	and	and	CCONJ
ecj-10810	56	11	vasoactive	vasoactive	ADJ
ecj-10810	56	12	drugs	drug	NOUN
ecj-10810	56	13	the	the	DET
ecj-10810	56	14	generalized	generalized	ADJ
ecj-10810	56	15	vasoplegia	vasoplegia	NOUN
ecj-10810	56	16	that	that	PRON
ecj-10810	56	17	characterizes	characterize	VERB
ecj-10810	56	18	septic	septic	ADJ
ecj-10810	56	19	shock	shock	NOUN
ecj-10810	56	20	causes	cause	VERB
ecj-10810	56	21	a	a	DET
ecj-10810	56	22	reduction	reduction	NOUN
ecj-10810	56	23	in	in	ADP
ecj-10810	56	24	venous	venous	ADJ
ecj-10810	56	25	tone	tone	NOUN
ecj-10810	56	26	with	with	ADP
ecj-10810	56	27	an	an	DET
ecj-10810	56	28	increase	increase	NOUN
ecj-10810	56	29	in	in	ADP
ecj-10810	56	30	vascular	vascular	ADJ
ecj-10810	56	31	bed	bed	NOUN
ecj-10810	56	32	capacitance	capacitance	NOUN
ecj-10810	56	33	.	.	PUNCT
ecj-10810	57	1	as	as	ADP
ecj-10810	57	2	a	a	DET
ecj-10810	57	3	consequence	consequence	NOUN
ecj-10810	57	4	,	,	PUNCT
ecj-10810	57	5	when	when	SCONJ
ecj-10810	57	6	physiological	physiological	ADJ
ecj-10810	57	7	compensation	compensation	NOUN
ecj-10810	57	8	mechanisms	mechanism	NOUN
ecj-10810	57	9	are	be	AUX
ecj-10810	57	10	inadequate	inadequate	ADJ
ecj-10810	57	11	,	,	PUNCT
ecj-10810	57	12	both	both	PRON
ecj-10810	57	13	stressed	stress	VERB
ecj-10810	57	14	volume	volume	NOUN
ecj-10810	57	15	and	and	CCONJ
ecj-10810	57	16	preload	preload	NOUN
ecj-10810	57	17	are	be	AUX
ecj-10810	57	18	reduced	reduce	VERB
ecj-10810	57	19	.	.	PUNCT
ecj-10810	58	1	this	this	DET
ecj-10810	58	2	situation	situation	NOUN
ecj-10810	58	3	can	can	AUX
ecj-10810	58	4	be	be	AUX
ecj-10810	58	5	managed	manage	VERB
ecj-10810	58	6	in	in	ADP
ecj-10810	58	7	one	one	NUM
ecj-10810	58	8	of	of	ADP
ecj-10810	58	9	two	two	NUM
ecj-10810	58	10	ways	way	NOUN
ecj-10810	58	11	:	:	PUNCT
ecj-10810	58	12	increasing	increase	VERB
ecj-10810	58	13	intravascular	intravascular	ADJ
ecj-10810	58	14	volume	volume	NOUN
ecj-10810	58	15	with	with	ADP
ecj-10810	58	16	fluids	fluid	NOUN
ecj-10810	58	17	or	or	CCONJ
ecj-10810	58	18	increasing	increase	VERB
ecj-10810	58	19	venous	venous	ADJ
ecj-10810	58	20	tone	tone	NOUN
ecj-10810	58	21	with	with	ADP
ecj-10810	58	22	vasopressors	vasopressor	NOUN
ecj-10810	58	23	.	.	PUNCT
ecj-10810	59	1	more	more	ADV
ecj-10810	59	2	often	often	ADV
ecj-10810	59	3	,	,	PUNCT
ecj-10810	59	4	the	the	DET
ecj-10810	59	5	decision	decision	NOUN
ecj-10810	59	6	is	be	AUX
ecj-10810	59	7	made	make	VERB
ecj-10810	59	8	to	to	PART
ecj-10810	59	9	administer	administer	VERB
ecj-10810	59	10	both	both	PRON
ecj-10810	59	11	,	,	PUNCT
ecj-10810	59	12	to	to	PART
ecj-10810	59	13	balance	balance	VERB
ecj-10810	59	14	the	the	DET
ecj-10810	59	15	positive	positive	ADJ
ecj-10810	59	16	and	and	CCONJ
ecj-10810	59	17	undesirable	undesirable	ADJ
ecj-10810	59	18	effects	effect	NOUN
ecj-10810	59	19	of	of	ADP
ecj-10810	59	20	the	the	DET
ecj-10810	59	21	two	two	NUM
ecj-10810	59	22	interventions	intervention	NOUN
ecj-10810	59	23	.	.	PUNCT
ecj-10810	60	1	fluids	fluid	NOUN
ecj-10810	60	2	crystalloids	crystalloid	NOUN
ecj-10810	60	3	are	be	AUX
ecj-10810	60	4	the	the	DET
ecj-10810	60	5	fluids	fluid	NOUN
ecj-10810	60	6	of	of	ADP
ecj-10810	60	7	choice	choice	NOUN
ecj-10810	60	8	because	because	SCONJ
ecj-10810	60	9	they	they	PRON
ecj-10810	60	10	have	have	VERB
ecj-10810	60	11	a	a	DET
ecj-10810	60	12	better	well	ADJ
ecj-10810	60	13	benefit	benefit	NOUN
ecj-10810	60	14	/	/	SYM
ecj-10810	60	15	risk	risk	NOUN
ecj-10810	60	16	ratio	ratio	NOUN
ecj-10810	60	17	than	than	ADP
ecj-10810	60	18	colloids.24	colloids.24	ADJ
ecj-10810	60	19	recent	recent	ADJ
ecj-10810	60	20	meta	meta	NOUN
ecj-10810	60	21	-	-	PUNCT
ecj-10810	60	22	analyses	analysis	NOUN
ecj-10810	60	23	are	be	AUX
ecj-10810	60	24	conflicting	conflict	VERB
ecj-10810	60	25	as	as	ADP
ecj-10810	60	26	to	to	ADP
ecj-10810	60	27	whether	whether	SCONJ
ecj-10810	60	28	balanced	balanced	ADJ
ecj-10810	60	29	crystalloid	crystalloid	PROPN
ecj-10810	60	30	solutions	solution	NOUN
ecj-10810	60	31	are	be	AUX
ecj-10810	60	32	superior	superior	ADJ
ecj-10810	60	33	to	to	PART
ecj-10810	60	34	saline	saline	VERB
ecj-10810	60	35	,	,	PUNCT
ecj-10810	60	36	but	but	CCONJ
ecj-10810	60	37	most	most	ADJ
ecj-10810	60	38	authors	author	NOUN
ecj-10810	60	39	recommend	recommend	VERB
ecj-10810	60	40	their	their	PRON
ecj-10810	60	41	use	use	NOUN
ecj-10810	60	42	since	since	SCONJ
ecj-10810	60	43	saline	saline	NOUN
ecj-10810	60	44	causes	cause	VERB
ecj-10810	60	45	hyperchloremic	hyperchloremic	ADJ
ecj-10810	60	46	metabolic	metabolic	NOUN
ecj-10810	60	47	acidosis	acidosis	NOUN
ecj-10810	60	48	when	when	SCONJ
ecj-10810	60	49	given	give	VERB
ecj-10810	60	50	rapidly	rapidly	ADV
ecj-10810	60	51	or	or	CCONJ
ecj-10810	60	52	in	in	ADP
ecj-10810	60	53	large	large	ADJ
ecj-10810	60	54	volumes	volume	NOUN
ecj-10810	60	55	and	and	CCONJ
ecj-10810	60	56	may	may	AUX
ecj-10810	60	57	increase	increase	VERB
ecj-10810	60	58	the	the	DET
ecj-10810	60	59	risk	risk	NOUN
ecj-10810	60	60	of	of	ADP
ecj-10810	60	61	acute	acute	ADJ
ecj-10810	60	62	kidney	kidney	NOUN
ecj-10810	60	63	injury.25	injury.25	PROPN
ecj-10810	60	64	-	-	PUNCT
ecj-10810	60	65	27	27	NUM
ecj-10810	60	66	the	the	DET
ecj-10810	60	67	main	main	ADJ
ecj-10810	60	68	problem	problem	NOUN
ecj-10810	60	69	with	with	ADP
ecj-10810	60	70	crystalloids	crystalloid	NOUN
ecj-10810	60	71	is	be	AUX
ecj-10810	60	72	their	their	PRON
ecj-10810	60	73	limited	limited	ADJ
ecj-10810	60	74	stay	stay	NOUN
ecj-10810	60	75	in	in	ADP
ecj-10810	60	76	the	the	DET
ecj-10810	60	77	intravascular	intravascular	ADJ
ecj-10810	60	78	space	space	NOUN
ecj-10810	60	79	and	and	CCONJ
ecj-10810	60	80	rapid	rapid	ADJ
ecj-10810	60	81	passage	passage	NOUN
ecj-10810	60	82	into	into	ADP
ecj-10810	60	83	the	the	DET
ecj-10810	60	84	interstitium	interstitium	NOUN
ecj-10810	60	85	of	of	ADP
ecj-10810	60	86	more	more	ADJ
ecj-10810	60	87	than	than	ADP
ecj-10810	60	88	three	three	NUM
ecj-10810	60	89	-	-	PUNCT
ecj-10810	60	90	quarters	quarter	NOUN
ecj-10810	60	91	of	of	ADP
ecj-10810	60	92	the	the	DET
ecj-10810	60	93	administered	administer	VERB
ecj-10810	60	94	volume	volume	NOUN
ecj-10810	60	95	.	.	PUNCT
ecj-10810	61	1	this	this	PRON
ecj-10810	61	2	is	be	AUX
ecj-10810	61	3	further	far	ADV
ecj-10810	61	4	promoted	promote	VERB
ecj-10810	61	5	by	by	ADP
ecj-10810	61	6	sepsis	sepsis	NOUN
ecj-10810	61	7	-	-	PUNCT
ecj-10810	61	8	induced	induce	VERB
ecj-10810	61	9	alterations	alteration	NOUN
ecj-10810	61	10	in	in	ADP
ecj-10810	61	11	endothelial	endothelial	ADJ
ecj-10810	61	12	permeability.28	permeability.28	ADJ
ecj-10810	61	13	interstitial	interstitial	ADJ
ecj-10810	61	14	edema	edema	NOUN
ecj-10810	61	15	hampers	hamper	VERB
ecj-10810	61	16	oxygen	oxygen	NOUN
ecj-10810	61	17	transport	transport	NOUN
ecj-10810	61	18	to	to	ADP
ecj-10810	61	19	the	the	DET
ecj-10810	61	20	tissues	tissue	NOUN
ecj-10810	61	21	and	and	CCONJ
ecj-10810	61	22	can	can	AUX
ecj-10810	61	23	be	be	AUX
ecj-10810	61	24	a	a	DET
ecj-10810	61	25	serious	serious	ADJ
ecj-10810	61	26	clinical	clinical	ADJ
ecj-10810	61	27	problem	problem	NOUN
ecj-10810	61	28	because	because	SCONJ
ecj-10810	61	29	it	it	PRON
ecj-10810	61	30	may	may	AUX
ecj-10810	61	31	affect	affect	VERB
ecj-10810	61	32	the	the	DET
ecj-10810	61	33	lung	lung	NOUN
ecj-10810	61	34	parenchyma	parenchyma	NOUN
ecj-10810	61	35	and	and	CCONJ
ecj-10810	61	36	increase	increase	VERB
ecj-10810	61	37	intra	intra	ADJ
ecj-10810	61	38	-	-	ADJ
ecj-10810	61	39	abdominal	abdominal	ADJ
ecj-10810	61	40	pressure	pressure	NOUN
ecj-10810	61	41	.	.	PUNCT
ecj-10810	62	1	finally	finally	ADV
ecj-10810	62	2	,	,	PUNCT
ecj-10810	62	3	fluid	fluid	ADJ
ecj-10810	62	4	administration	administration	NOUN
ecj-10810	62	5	may	may	AUX
ecj-10810	62	6	be	be	AUX
ecj-10810	62	7	ineffective	ineffective	ADJ
ecj-10810	62	8	in	in	ADP
ecj-10810	62	9	patients	patient	NOUN
ecj-10810	62	10	with	with	ADP
ecj-10810	62	11	left	left	ADJ
ecj-10810	62	12	ventricular	ventricular	ADJ
ecj-10810	62	13	failure	failure	NOUN
ecj-10810	62	14	who	who	PRON
ecj-10810	62	15	reach	reach	VERB
ecj-10810	62	16	the	the	DET
ecj-10810	62	17	plateau	plateau	NOUN
ecj-10810	62	18	phase	phase	NOUN
ecj-10810	62	19	of	of	ADP
ecj-10810	62	20	the	the	DET
ecj-10810	62	21	frank	frank	ADJ
ecj-10810	62	22	-	-	PUNCT
ecj-10810	62	23	starling	starle	VERB
ecj-10810	62	24	curve	curve	NOUN
ecj-10810	62	25	very	very	ADV
ecj-10810	62	26	early	early	ADV
ecj-10810	62	27	(	(	PUNCT
ecj-10810	62	28	figure	figure	NOUN
ecj-10810	62	29	1	1	NUM
ecj-10810	62	30	)	)	PUNCT
ecj-10810	62	31	.	.	PUNCT
ecj-10810	63	1	in	in	ADP
ecj-10810	63	2	this	this	DET
ecj-10810	63	3	case	case	NOUN
ecj-10810	63	4	,	,	PUNCT
ecj-10810	63	5	the	the	DET
ecj-10810	63	6	effect	effect	NOUN
ecj-10810	63	7	of	of	ADP
ecj-10810	63	8	preload	preload	NOUN
ecj-10810	63	9	on	on	ADP
ecj-10810	63	10	stroke	stroke	NOUN
ecj-10810	63	11	volume	volume	NOUN
ecj-10810	63	12	may	may	AUX
ecj-10810	63	13	be	be	AUX
ecj-10810	63	14	little	little	ADJ
ecj-10810	63	15	or	or	CCONJ
ecj-10810	63	16	absent	absent	ADJ
ecj-10810	63	17	,	,	PUNCT
ecj-10810	63	18	when	when	SCONJ
ecj-10810	63	19	not	not	PART
ecj-10810	63	20	counterproductive	counterproductive	ADJ
ecj-10810	63	21	.	.	PUNCT
ecj-10810	64	1	the	the	DET
ecj-10810	64	2	evaluation	evaluation	NOUN
ecj-10810	64	3	of	of	ADP
ecj-10810	64	4	fluid	fluid	ADJ
ecj-10810	64	5	responsiveness	responsiveness	NOUN
ecj-10810	64	6	,	,	PUNCT
ecj-10810	64	7	especially	especially	ADV
ecj-10810	64	8	outside	outside	ADP
ecj-10810	64	9	the	the	DET
ecj-10810	64	10	icu	icu	PROPN
ecj-10810	64	11	,	,	PUNCT
ecj-10810	64	12	is	be	AUX
ecj-10810	64	13	a	a	DET
ecj-10810	64	14	much	much	ADV
ecj-10810	64	15	-	-	PUNCT
ecj-10810	64	16	discussed	discuss	VERB
ecj-10810	64	17	item	item	NOUN
ecj-10810	64	18	that	that	PRON
ecj-10810	64	19	goes	go	VERB
ecj-10810	64	20	beyond	beyond	ADP
ecj-10810	64	21	the	the	DET
ecj-10810	64	22	aims	aim	NOUN
ecj-10810	64	23	of	of	ADP
ecj-10810	64	24	this	this	DET
ecj-10810	64	25	review.29	review.29	NOUN
ecj-10810	64	26	measuring	measure	VERB
ecj-10810	64	27	sv	sv	NOUN
ecj-10810	64	28	modification	modification	NOUN
ecj-10810	64	29	after	after	ADP
ecj-10810	64	30	passive	passive	ADJ
ecj-10810	64	31	leg	leg	NOUN
ecj-10810	64	32	raising	raising	NOUN
ecj-10810	64	33	or	or	CCONJ
ecj-10810	64	34	a	a	DET
ecj-10810	64	35	fluid	fluid	ADJ
ecj-10810	64	36	bolus	bolus	ADJ
ecj-10810	64	37	administration	administration	NOUN
ecj-10810	64	38	is	be	AUX
ecj-10810	64	39	the	the	DET
ecj-10810	64	40	preferred	preferred	ADJ
ecj-10810	64	41	method	method	NOUN
ecj-10810	64	42	when	when	SCONJ
ecj-10810	64	43	instrumentation	instrumentation	NOUN
ecj-10810	64	44	and	and	CCONJ
ecj-10810	64	45	expertise	expertise	NOUN
ecj-10810	64	46	are	be	AUX
ecj-10810	64	47	available	available	ADJ
ecj-10810	64	48	.	.	PUNCT
ecj-10810	65	1	echocardiography	echocardiography	NOUN
ecj-10810	65	2	is	be	AUX
ecj-10810	65	3	probably	probably	ADV
ecj-10810	65	4	the	the	DET
ecj-10810	65	5	best	good	ADJ
ecj-10810	65	6	option	option	NOUN
ecj-10810	65	7	to	to	PART
ecj-10810	65	8	measure	measure	VERB
ecj-10810	65	9	sv	sv	INTJ
ecj-10810	65	10	in	in	ADP
ecj-10810	65	11	the	the	DET
ecj-10810	65	12	ed	ed	NOUN
ecj-10810	65	13	setting	setting	NOUN
ecj-10810	65	14	,	,	PUNCT
ecj-10810	65	15	since	since	SCONJ
ecj-10810	65	16	the	the	DET
ecj-10810	65	17	number	number	NOUN
ecj-10810	65	18	review	review	NOUN
ecj-10810	65	19	[	[	X
ecj-10810	65	20	emergency	emergency	NOUN
ecj-10810	65	21	care	care	NOUN
ecj-10810	65	22	journal	journal	NOUN
ecj-10810	65	23	2023	2023	NUM
ecj-10810	65	24	;	;	PUNCT
ecj-10810	65	25	19:10810	19:10810	NUM
ecj-10810	65	26	]	]	X
ecj-10810	66	1	[	[	X
ecj-10810	66	2	page	page	NOUN
ecj-10810	66	3	11	11	NUM
ecj-10810	66	4	]	]	PUNCT
ecj-10810	66	5	non	non	ADJ
ecj-10810	66	6	-co	-co	PROPN
ecj-10810	66	7	mmerc	mmerc	PROPN
ecj-10810	66	8	ial	ial	PROPN
ecj-10810	66	9	us	us	PROPN
ecj-10810	66	10	e	e	NOUN
ecj-10810	66	11	o	o	NOUN
ecj-10810	66	12	nly	nly	ADV
ecj-10810	66	13	of	of	ADP
ecj-10810	66	14	emergency	emergency	NOUN
ecj-10810	66	15	doctors	doctor	NOUN
ecj-10810	66	16	trained	train	VERB
ecj-10810	66	17	in	in	ADP
ecj-10810	66	18	this	this	DET
ecj-10810	66	19	technique	technique	NOUN
ecj-10810	66	20	is	be	AUX
ecj-10810	66	21	growing	grow	VERB
ecj-10810	66	22	,	,	PUNCT
ecj-10810	66	23	while	while	SCONJ
ecj-10810	66	24	other	other	ADJ
ecj-10810	66	25	non	non	ADJ
ecj-10810	66	26	-	-	ADJ
ecj-10810	66	27	invasive	invasive	ADJ
ecj-10810	66	28	approaches	approach	NOUN
ecj-10810	66	29	are	be	AUX
ecj-10810	66	30	either	either	CCONJ
ecj-10810	66	31	too	too	ADV
ecj-10810	66	32	clumsy	clumsy	ADJ
ecj-10810	66	33	to	to	PART
ecj-10810	66	34	use	use	VERB
ecj-10810	66	35	or	or	CCONJ
ecj-10810	66	36	simply	simply	ADV
ecj-10810	66	37	too	too	ADV
ecj-10810	66	38	little	little	ADJ
ecj-10810	66	39	diffused	diffused	ADJ
ecj-10810	66	40	.	.	PUNCT
ecj-10810	67	1	other	other	ADJ
ecj-10810	67	2	measures	measure	NOUN
ecj-10810	67	3	,	,	PUNCT
ecj-10810	67	4	like	like	ADP
ecj-10810	67	5	respiratory	respiratory	ADJ
ecj-10810	67	6	diameter	diameter	NOUN
ecj-10810	67	7	variation	variation	NOUN
ecj-10810	67	8	of	of	ADP
ecj-10810	67	9	the	the	DET
ecj-10810	67	10	inferior	inferior	ADJ
ecj-10810	67	11	vena	vena	NOUN
ecj-10810	67	12	cava	cava	NOUN
ecj-10810	67	13	,	,	PUNCT
ecj-10810	67	14	require	require	VERB
ecj-10810	67	15	confirmatory	confirmatory	ADJ
ecj-10810	67	16	studies	study	NOUN
ecj-10810	67	17	and	and	CCONJ
ecj-10810	67	18	are	be	AUX
ecj-10810	67	19	reliable	reliable	ADJ
ecj-10810	67	20	in	in	ADP
ecj-10810	67	21	non	non	ADJ
ecj-10810	67	22	-	-	ADJ
ecj-10810	67	23	ventilated	ventilated	ADJ
ecj-10810	67	24	patients	patient	NOUN
ecj-10810	67	25	only	only	ADV
ecj-10810	67	26	for	for	ADP
ecj-10810	67	27	very	very	ADV
ecj-10810	67	28	significant	significant	ADJ
ecj-10810	67	29	changes.30	changes.30	NOUN
ecj-10810	67	30	yet	yet	ADV
ecj-10810	67	31	,	,	PUNCT
ecj-10810	67	32	most	most	ADJ
ecj-10810	67	33	patients	patient	NOUN
ecj-10810	67	34	in	in	ADP
ecj-10810	67	35	septic	septic	ADJ
ecj-10810	67	36	shock	shock	NOUN
ecj-10810	67	37	do	do	AUX
ecj-10810	67	38	show	show	VERB
ecj-10810	67	39	a	a	DET
ecj-10810	67	40	complete	complete	ADJ
ecj-10810	67	41	inspiratory	inspiratory	NOUN
ecj-10810	67	42	collapse	collapse	NOUN
ecj-10810	67	43	of	of	ADP
ecj-10810	67	44	the	the	DET
ecj-10810	67	45	inferior	inferior	ADJ
ecj-10810	67	46	vena	vena	NOUN
ecj-10810	67	47	cava	cava	NOUN
ecj-10810	67	48	,	,	PUNCT
ecj-10810	67	49	and	and	CCONJ
ecj-10810	67	50	this	this	PRON
ecj-10810	67	51	can	can	AUX
ecj-10810	67	52	be	be	AUX
ecj-10810	67	53	used	use	VERB
ecj-10810	67	54	as	as	ADP
ecj-10810	67	55	a	a	DET
ecj-10810	67	56	proxy	proxy	ADJ
ecj-10810	67	57	indicator	indicator	NOUN
ecj-10810	67	58	of	of	ADP
ecj-10810	67	59	fluid	fluid	ADJ
ecj-10810	67	60	responsiveness	responsiveness	NOUN
ecj-10810	67	61	,	,	PUNCT
ecj-10810	67	62	or	or	CCONJ
ecj-10810	67	63	at	at	ADP
ecj-10810	67	64	least	least	ADJ
ecj-10810	67	65	of	of	ADP
ecj-10810	67	66	the	the	DET
ecj-10810	67	67	patient	patient	NOUN
ecj-10810	67	68	’s	’s	PART
ecj-10810	67	69	capability	capability	NOUN
ecj-10810	67	70	to	to	PART
ecj-10810	67	71	tolerate	tolerate	VERB
ecj-10810	67	72	a	a	DET
ecj-10810	67	73	further	further	ADJ
ecj-10810	67	74	fluid	fluid	ADJ
ecj-10810	67	75	bolus	bolus	NOUN
ecj-10810	67	76	.	.	PUNCT
ecj-10810	68	1	lastly	lastly	ADV
ecj-10810	68	2	,	,	PUNCT
ecj-10810	68	3	it	it	PRON
ecj-10810	68	4	is	be	AUX
ecj-10810	68	5	important	important	ADJ
ecj-10810	68	6	to	to	PART
ecj-10810	68	7	point	point	VERB
ecj-10810	68	8	out	out	ADP
ecj-10810	68	9	that	that	SCONJ
ecj-10810	68	10	being	be	AUX
ecj-10810	68	11	a	a	DET
ecj-10810	68	12	fluid	fluid	ADJ
ecj-10810	68	13	responder	responder	NOUN
ecj-10810	68	14	does	do	AUX
ecj-10810	68	15	n’t	not	PART
ecj-10810	68	16	necessarily	necessarily	ADV
ecj-10810	68	17	mean	mean	VERB
ecj-10810	68	18	requiring	require	VERB
ecj-10810	68	19	fluids	fluid	NOUN
ecj-10810	68	20	.	.	PUNCT
ecj-10810	69	1	most	most	ADJ
ecj-10810	69	2	people	people	NOUN
ecj-10810	69	3	who	who	PRON
ecj-10810	69	4	are	be	AUX
ecj-10810	69	5	well	well	ADJ
ecj-10810	69	6	and	and	CCONJ
ecj-10810	69	7	in	in	ADP
ecj-10810	69	8	hemodynamic	hemodynamic	ADJ
ecj-10810	69	9	equilibrium	equilibrium	NOUN
ecj-10810	69	10	will	will	AUX
ecj-10810	69	11	respond	respond	VERB
ecj-10810	69	12	to	to	ADP
ecj-10810	69	13	fluids	fluid	NOUN
ecj-10810	69	14	,	,	PUNCT
ecj-10810	69	15	but	but	CCONJ
ecj-10810	69	16	this	this	PRON
ecj-10810	69	17	is	be	AUX
ecj-10810	69	18	not	not	PART
ecj-10810	69	19	a	a	DET
ecj-10810	69	20	good	good	ADJ
ecj-10810	69	21	reason	reason	NOUN
ecj-10810	69	22	to	to	PART
ecj-10810	69	23	treat	treat	VERB
ecj-10810	69	24	them	they	PRON
ecj-10810	69	25	.	.	PUNCT
ecj-10810	70	1	vasopressors	vasopressor	NOUN
ecj-10810	70	2	the	the	DET
ecj-10810	70	3	choice	choice	NOUN
ecj-10810	70	4	generally	generally	ADV
ecj-10810	70	5	falls	fall	VERB
ecj-10810	70	6	on	on	ADP
ecj-10810	70	7	norepinephrine31	norepinephrine31	NOUN
ecj-10810	70	8	which	which	PRON
ecj-10810	70	9	has	have	VERB
ecj-10810	70	10	a	a	DET
ecj-10810	70	11	higher	high	ADJ
ecj-10810	70	12	a1	a1	NOUN
ecj-10810	70	13	-	-	PUNCT
ecj-10810	70	14	receptor	receptor	NOUN
ecj-10810	70	15	affinity	affinity	NOUN
ecj-10810	70	16	and	and	CCONJ
ecj-10810	70	17	safety	safety	NOUN
ecj-10810	70	18	profile	profile	NOUN
ecj-10810	70	19	than	than	SCONJ
ecj-10810	70	20	dopamine	dopamine	NOUN
ecj-10810	70	21	and	and	CCONJ
ecj-10810	70	22	adrenaline.32,33	adrenaline.32,33	NOUN
ecj-10810	70	23	noradrenaline	noradrenaline	NOUN
ecj-10810	70	24	mainly	mainly	ADV
ecj-10810	70	25	affects	affect	VERB
ecj-10810	70	26	co	co	VERB
ecj-10810	70	27	by	by	ADP
ecj-10810	70	28	reducing	reduce	VERB
ecj-10810	70	29	the	the	DET
ecj-10810	70	30	capacitance	capacitance	NOUN
ecj-10810	70	31	of	of	ADP
ecj-10810	70	32	the	the	DET
ecj-10810	70	33	venous	venous	ADJ
ecj-10810	70	34	circulation	circulation	NOUN
ecj-10810	70	35	,	,	PUNCT
ecj-10810	70	36	thus	thus	ADV
ecj-10810	70	37	increasing	increase	VERB
ecj-10810	70	38	stressed	stressed	ADJ
ecj-10810	70	39	volume	volume	NOUN
ecj-10810	70	40	and	and	CCONJ
ecj-10810	70	41	venous	venous	ADJ
ecj-10810	70	42	return	return	NOUN
ecj-10810	70	43	.	.	PUNCT
ecj-10810	71	1	the	the	DET
ecj-10810	71	2	problem	problem	NOUN
ecj-10810	71	3	with	with	ADP
ecj-10810	71	4	noradrenaline	noradrenaline	NOUN
ecj-10810	71	5	(	(	PUNCT
ecj-10810	71	6	especially	especially	ADV
ecj-10810	71	7	at	at	ADP
ecj-10810	71	8	the	the	DET
ecj-10810	71	9	higher	high	ADJ
ecj-10810	71	10	doses	dose	NOUN
ecj-10810	71	11	)	)	PUNCT
ecj-10810	71	12	is	be	AUX
ecj-10810	71	13	an	an	DET
ecj-10810	71	14	increase	increase	NOUN
ecj-10810	71	15	in	in	ADP
ecj-10810	71	16	svr	svr	PROPN
ecj-10810	71	17	which	which	PRON
ecj-10810	71	18	could	could	AUX
ecj-10810	71	19	cause	cause	VERB
ecj-10810	71	20	an	an	DET
ecj-10810	71	21	excessive	excessive	ADJ
ecj-10810	71	22	load	load	NOUN
ecj-10810	71	23	for	for	ADP
ecj-10810	71	24	a	a	DET
ecj-10810	71	25	failing	fail	VERB
ecj-10810	71	26	heart	heart	NOUN
ecj-10810	71	27	,	,	PUNCT
ecj-10810	71	28	despite	despite	SCONJ
ecj-10810	71	29	the	the	DET
ecj-10810	71	30	positive	positive	ADJ
ecj-10810	71	31	inotropic	inotropic	ADJ
ecj-10810	71	32	effect	effect	NOUN
ecj-10810	71	33	of	of	ADP
ecj-10810	71	34	this	this	DET
ecj-10810	71	35	drug.34	drug.34	NOUN
ecj-10810	71	36	lastly	lastly	ADV
ecj-10810	71	37	,	,	PUNCT
ecj-10810	71	38	the	the	DET
ecj-10810	71	39	effect	effect	NOUN
ecj-10810	71	40	of	of	ADP
ecj-10810	71	41	vasopressors	vasopressor	NOUN
ecj-10810	71	42	on	on	ADP
ecj-10810	71	43	septic	septic	ADJ
ecj-10810	71	44	shock	shock	NOUN
ecj-10810	71	45	is	be	AUX
ecj-10810	71	46	difficult	difficult	ADJ
ecj-10810	71	47	to	to	PART
ecj-10810	71	48	foresee	foresee	VERB
ecj-10810	71	49	,	,	PUNCT
ecj-10810	71	50	considering	consider	VERB
ecj-10810	71	51	that	that	SCONJ
ecj-10810	71	52	an	an	DET
ecj-10810	71	53	altered	altered	ADJ
ecj-10810	71	54	response	response	NOUN
ecj-10810	71	55	to	to	ADP
ecj-10810	71	56	adrenergic	adrenergic	ADJ
ecj-10810	71	57	stimulation	stimulation	NOUN
ecj-10810	71	58	is	be	AUX
ecj-10810	71	59	often	often	ADV
ecj-10810	71	60	encountered	encounter	VERB
ecj-10810	71	61	in	in	ADP
ecj-10810	71	62	patients	patient	NOUN
ecj-10810	71	63	with	with	ADP
ecj-10810	71	64	overwhelming	overwhelming	ADJ
ecj-10810	71	65	bacterial	bacterial	ADJ
ecj-10810	71	66	infections.35	infections.35	PROPN
ecj-10810	71	67	inotropes	inotropes	PROPN
ecj-10810	71	68	administration	administration	NOUN
ecj-10810	71	69	of	of	ADP
ecj-10810	71	70	dobutamine	dobutamine	PROPN
ecj-10810	71	71	has	have	VERB
ecj-10810	71	72	a	a	DET
ecj-10810	71	73	sound	sound	ADJ
ecj-10810	71	74	pathophysiological	pathophysiological	ADJ
ecj-10810	71	75	basis	basis	NOUN
ecj-10810	71	76	and	and	CCONJ
ecj-10810	71	77	is	be	AUX
ecj-10810	71	78	employed	employ	VERB
ecj-10810	71	79	in	in	ADP
ecj-10810	71	80	patients	patient	NOUN
ecj-10810	71	81	with	with	ADP
ecj-10810	71	82	septic	septic	ADJ
ecj-10810	71	83	shock	shock	NOUN
ecj-10810	71	84	that	that	PRON
ecj-10810	71	85	persists	persist	VERB
ecj-10810	71	86	after	after	ADP
ecj-10810	71	87	adequate	adequate	ADJ
ecj-10810	71	88	fluid	fluid	ADJ
ecj-10810	71	89	loading	loading	NOUN
ecj-10810	71	90	and	and	CCONJ
ecj-10810	71	91	administration	administration	NOUN
ecj-10810	71	92	of	of	ADP
ecj-10810	71	93	noradrenaline	noradrenaline	NOUN
ecj-10810	71	94	,	,	PUNCT
ecj-10810	71	95	because	because	SCONJ
ecj-10810	71	96	of	of	ADP
ecj-10810	71	97	its	its	PRON
ecj-10810	71	98	important	important	ADJ
ecj-10810	71	99	inotropic	inotropic	ADJ
ecj-10810	71	100	effect.36	effect.36	NOUN
ecj-10810	71	101	undesirable	undesirable	ADJ
ecj-10810	71	102	effects	effect	NOUN
ecj-10810	71	103	of	of	ADP
ecj-10810	71	104	dobutamine	dobutamine	NOUN
ecj-10810	71	105	include	include	VERB
ecj-10810	71	106	increased	increase	VERB
ecj-10810	71	107	myocardial	myocardial	ADJ
ecj-10810	71	108	o2	o2	ADJ
ecj-10810	71	109	consumption	consumption	NOUN
ecj-10810	71	110	and	and	CCONJ
ecj-10810	71	111	its	its	PRON
ecj-10810	71	112	action	action	NOUN
ecj-10810	71	113	on	on	ADP
ecj-10810	71	114	the	the	DET
ecj-10810	71	115	av	av	PROPN
ecj-10810	71	116	node	node	NOUN
ecj-10810	71	117	that	that	PRON
ecj-10810	71	118	can	can	AUX
ecj-10810	71	119	increase	increase	VERB
ecj-10810	71	120	heart	heart	NOUN
ecj-10810	71	121	rate	rate	NOUN
ecj-10810	71	122	in	in	ADP
ecj-10810	71	123	patients	patient	NOUN
ecj-10810	71	124	with	with	ADP
ecj-10810	71	125	af.37	af.37	PROPN
ecj-10810	71	126	before	before	ADP
ecj-10810	71	127	moving	move	VERB
ecj-10810	71	128	on	on	ADP
ecj-10810	71	129	to	to	ADP
ecj-10810	71	130	clinical	clinical	ADJ
ecj-10810	71	131	studies	study	NOUN
ecj-10810	71	132	,	,	PUNCT
ecj-10810	71	133	it	it	PRON
ecj-10810	71	134	may	may	AUX
ecj-10810	71	135	be	be	AUX
ecj-10810	71	136	helpful	helpful	ADJ
ecj-10810	71	137	to	to	PART
ecj-10810	71	138	summarize	summarize	VERB
ecj-10810	71	139	the	the	DET
ecj-10810	71	140	main	main	ADJ
ecj-10810	71	141	messages	message	NOUN
ecj-10810	71	142	of	of	ADP
ecj-10810	71	143	this	this	DET
ecj-10810	71	144	very	very	ADV
ecj-10810	71	145	concise	concise	ADJ
ecj-10810	71	146	overview	overview	NOUN
ecj-10810	71	147	on	on	ADP
ecj-10810	71	148	the	the	DET
ecj-10810	71	149	pathophysiology	pathophysiology	NOUN
ecj-10810	71	150	and	and	CCONJ
ecj-10810	71	151	pharmacology	pharmacology	NOUN
ecj-10810	71	152	of	of	ADP
ecj-10810	71	153	septic	septic	ADJ
ecj-10810	71	154	shock	shock	NOUN
ecj-10810	71	155	.	.	PUNCT
ecj-10810	72	1	data	datum	NOUN
ecj-10810	72	2	on	on	ADP
ecj-10810	72	3	macrocirculation	macrocirculation	NOUN
ecj-10810	72	4	and	and	CCONJ
ecj-10810	72	5	hemodynamics	hemodynamic	NOUN
ecj-10810	72	6	corroborate	corroborate	VERB
ecj-10810	72	7	the	the	DET
ecj-10810	72	8	importance	importance	NOUN
ecj-10810	72	9	of	of	ADP
ecj-10810	72	10	both	both	DET
ecj-10810	72	11	fluids	fluid	NOUN
ecj-10810	72	12	and	and	CCONJ
ecj-10810	72	13	vasopressor	vasopressor	NOUN
ecj-10810	72	14	drugs	drug	NOUN
ecj-10810	72	15	in	in	ADP
ecj-10810	72	16	improving	improve	VERB
ecj-10810	72	17	preload	preload	NOUN
ecj-10810	72	18	and	and	CCONJ
ecj-10810	72	19	co.	co.	PROPN
ecj-10810	72	20	however	however	ADV
ecj-10810	72	21	,	,	PUNCT
ecj-10810	72	22	they	they	PRON
ecj-10810	72	23	also	also	ADV
ecj-10810	72	24	show	show	VERB
ecj-10810	72	25	that	that	SCONJ
ecj-10810	72	26	the	the	DET
ecj-10810	72	27	efficacy	efficacy	NOUN
ecj-10810	72	28	of	of	ADP
ecj-10810	72	29	fluids	fluid	NOUN
ecj-10810	72	30	on	on	ADP
ecj-10810	72	31	preload	preload	NOUN
ecj-10810	72	32	decreases	decrease	NOUN
ecj-10810	72	33	approaching	approach	VERB
ecj-10810	72	34	the	the	DET
ecj-10810	72	35	plateau	plateau	NOUN
ecj-10810	72	36	phase	phase	NOUN
ecj-10810	72	37	of	of	ADP
ecj-10810	72	38	the	the	DET
ecj-10810	72	39	frank	frank	ADJ
ecj-10810	72	40	-	-	PUNCT
ecj-10810	72	41	starling	starle	VERB
ecj-10810	72	42	curve	curve	NOUN
ecj-10810	72	43	and	and	CCONJ
ecj-10810	72	44	that	that	SCONJ
ecj-10810	72	45	this	this	PRON
ecj-10810	72	46	happens	happen	VERB
ecj-10810	72	47	much	much	ADV
ecj-10810	72	48	earlier	early	ADV
ecj-10810	72	49	in	in	ADP
ecj-10810	72	50	patients	patient	NOUN
ecj-10810	72	51	with	with	ADP
ecj-10810	72	52	left	left	ADJ
ecj-10810	72	53	ventricular	ventricular	ADJ
ecj-10810	72	54	failure	failure	NOUN
ecj-10810	72	55	.	.	PUNCT
ecj-10810	73	1	because	because	SCONJ
ecj-10810	73	2	of	of	ADP
ecj-10810	73	3	the	the	DET
ecj-10810	73	4	risk	risk	NOUN
ecj-10810	73	5	of	of	ADP
ecj-10810	73	6	pulmonary	pulmonary	ADJ
ecj-10810	73	7	edema	edema	NOUN
ecj-10810	73	8	,	,	PUNCT
ecj-10810	73	9	fluid	fluid	ADJ
ecj-10810	73	10	administration	administration	NOUN
ecj-10810	73	11	to	to	ADP
ecj-10810	73	12	these	these	DET
ecj-10810	73	13	patients	patient	NOUN
ecj-10810	73	14	should	should	AUX
ecj-10810	73	15	be	be	AUX
ecj-10810	73	16	particularly	particularly	ADV
ecj-10810	73	17	careful	careful	ADJ
ecj-10810	73	18	.	.	PUNCT
ecj-10810	74	1	noradrenaline	noradrenaline	PROPN
ecj-10810	74	2	finds	find	VERB
ecj-10810	74	3	a	a	DET
ecj-10810	74	4	strong	strong	ADJ
ecj-10810	74	5	rationale	rationale	NOUN
ecj-10810	74	6	in	in	ADP
ecj-10810	74	7	its	its	PRON
ecj-10810	74	8	positive	positive	ADJ
ecj-10810	74	9	effects	effect	NOUN
ecj-10810	74	10	on	on	ADP
ecj-10810	74	11	preload	preload	NOUN
ecj-10810	74	12	and	and	CCONJ
ecj-10810	74	13	there	there	PRON
ecj-10810	74	14	are	be	VERB
ecj-10810	74	15	sound	sound	ADJ
ecj-10810	74	16	reasons	reason	NOUN
ecj-10810	74	17	to	to	PART
ecj-10810	74	18	support	support	VERB
ecj-10810	74	19	its	its	PRON
ecj-10810	74	20	use	use	NOUN
ecj-10810	74	21	in	in	ADP
ecj-10810	74	22	the	the	DET
ecj-10810	74	23	early	early	ADJ
ecj-10810	74	24	stage	stage	NOUN
ecj-10810	74	25	of	of	ADP
ecj-10810	74	26	septic	septic	ADJ
ecj-10810	74	27	shock	shock	NOUN
ecj-10810	74	28	,	,	PUNCT
ecj-10810	74	29	following	follow	VERB
ecj-10810	74	30	initial	initial	ADJ
ecj-10810	74	31	fluid	fluid	ADJ
ecj-10810	74	32	replenishment	replenishment	NOUN
ecj-10810	74	33	.	.	PUNCT
ecj-10810	75	1	lastly	lastly	ADV
ecj-10810	75	2	,	,	PUNCT
ecj-10810	75	3	the	the	DET
ecj-10810	75	4	analysis	analysis	NOUN
ecj-10810	75	5	of	of	ADP
ecj-10810	75	6	microcirculatory	microcirculatory	ADJ
ecj-10810	75	7	changes	change	NOUN
ecj-10810	75	8	,	,	PUNCT
ecj-10810	75	9	which	which	PRON
ecj-10810	75	10	are	be	AUX
ecj-10810	75	11	complex	complex	ADJ
ecj-10810	75	12	,	,	PUNCT
ecj-10810	75	13	variable	variable	ADJ
ecj-10810	75	14	,	,	PUNCT
ecj-10810	75	15	and	and	CCONJ
ecj-10810	75	16	not	not	PART
ecj-10810	75	17	directly	directly	ADV
ecj-10810	75	18	measurable	measurable	ADJ
ecj-10810	75	19	,	,	PUNCT
ecj-10810	75	20	cautions	caution	VERB
ecj-10810	75	21	against	against	ADP
ecj-10810	75	22	the	the	DET
ecj-10810	75	23	illusion	illusion	NOUN
ecj-10810	75	24	that	that	SCONJ
ecj-10810	75	25	a	a	DET
ecj-10810	75	26	standardized	standardized	ADJ
ecj-10810	75	27	(	(	PUNCT
ecj-10810	75	28	“	"	PUNCT
ecj-10810	75	29	one	one	NOUN
ecj-10810	75	30	fits	fit	VERB
ecj-10810	75	31	all	all	PRON
ecj-10810	75	32	”	"	PUNCT
ecj-10810	75	33	)	)	PUNCT
ecj-10810	75	34	treatment	treatment	NOUN
ecj-10810	75	35	can	can	AUX
ecj-10810	75	36	be	be	AUX
ecj-10810	75	37	used	use	VERB
ecj-10810	75	38	,	,	PUNCT
ecj-10810	75	39	and	and	CCONJ
ecj-10810	75	40	reminds	remind	VERB
ecj-10810	75	41	us	we	PRON
ecj-10810	75	42	of	of	ADP
ecj-10810	75	43	the	the	DET
ecj-10810	75	44	importance	importance	NOUN
ecj-10810	75	45	of	of	ADP
ecj-10810	75	46	an	an	DET
ecj-10810	75	47	individualized	individualized	ADJ
ecj-10810	75	48	therapeutic	therapeutic	ADJ
ecj-10810	75	49	approach	approach	NOUN
ecj-10810	75	50	.	.	PUNCT
ecj-10810	76	1	epidemiological	epidemiological	ADJ
ecj-10810	76	2	data	datum	NOUN
ecj-10810	76	3	epidemiological	epidemiological	ADJ
ecj-10810	76	4	data	datum	NOUN
ecj-10810	76	5	clearly	clearly	ADV
ecj-10810	76	6	show	show	VERB
ecj-10810	76	7	that	that	SCONJ
ecj-10810	76	8	mortality	mortality	NOUN
ecj-10810	76	9	from	from	ADP
ecj-10810	76	10	sepsis	sepsis	NOUN
ecj-10810	76	11	has	have	AUX
ecj-10810	76	12	fallen	fall	VERB
ecj-10810	76	13	over	over	ADP
ecj-10810	76	14	the	the	DET
ecj-10810	76	15	past	past	ADJ
ecj-10810	76	16	two	two	NUM
ecj-10810	76	17	decades	decade	NOUN
ecj-10810	76	18	,	,	PUNCT
ecj-10810	76	19	although	although	SCONJ
ecj-10810	76	20	the	the	DET
ecj-10810	76	21	incidence	incidence	NOUN
ecj-10810	76	22	of	of	ADP
ecj-10810	76	23	this	this	DET
ecj-10810	76	24	syndrome	syndrome	NOUN
ecj-10810	76	25	has	have	AUX
ecj-10810	76	26	not	not	PART
ecj-10810	76	27	declined.1	declined.1	PROPN
ecj-10810	76	28	they	they	PRON
ecj-10810	76	29	also	also	ADV
ecj-10810	76	30	show	show	VERB
ecj-10810	76	31	that	that	SCONJ
ecj-10810	76	32	mortality	mortality	NOUN
ecj-10810	76	33	is	be	AUX
ecj-10810	76	34	related	relate	VERB
ecj-10810	76	35	to	to	ADP
ecj-10810	76	36	factors	factor	NOUN
ecj-10810	76	37	such	such	ADJ
ecj-10810	76	38	as	as	ADP
ecj-10810	76	39	the	the	DET
ecj-10810	76	40	site	site	NOUN
ecj-10810	76	41	of	of	ADP
ecj-10810	76	42	infection	infection	NOUN
ecj-10810	76	43	(	(	PUNCT
ecj-10810	76	44	e.g.	e.g.	ADV
ecj-10810	76	45	,	,	PUNCT
ecj-10810	76	46	lung	lung	NOUN
ecj-10810	76	47	more	more	ADJ
ecj-10810	76	48	than	than	ADP
ecj-10810	76	49	urinary	urinary	ADJ
ecj-10810	76	50	tract	tract	NOUN
ecj-10810	76	51	)	)	PUNCT
ecj-10810	76	52	,	,	PUNCT
ecj-10810	76	53	age	age	NOUN
ecj-10810	76	54	(	(	PUNCT
ecj-10810	76	55	in	in	ADP
ecj-10810	76	56	england	england	PROPN
ecj-10810	76	57	,	,	PUNCT
ecj-10810	76	58	nearly	nearly	ADV
ecj-10810	76	59	80	80	NUM
ecj-10810	76	60	%	%	NOUN
ecj-10810	76	61	of	of	ADP
ecj-10810	76	62	patients	patient	NOUN
ecj-10810	76	63	who	who	PRON
ecj-10810	76	64	die	die	VERB
ecj-10810	76	65	from	from	ADP
ecj-10810	76	66	sepsis	sepsis	NOUN
ecj-10810	76	67	are	be	AUX
ecj-10810	76	68	over	over	ADP
ecj-10810	76	69	75	75	NUM
ecj-10810	76	70	years	year	NOUN
ecj-10810	76	71	old	old	ADJ
ecj-10810	76	72	)	)	PUNCT
ecj-10810	76	73	,	,	PUNCT
ecj-10810	76	74	and	and	CCONJ
ecj-10810	76	75	a	a	DET
ecj-10810	76	76	state	state	NOUN
ecj-10810	76	77	of	of	ADP
ecj-10810	76	78	fragility	fragility	NOUN
ecj-10810	76	79	.	.	PUNCT
ecj-10810	77	1	an	an	DET
ecj-10810	77	2	interesting	interesting	ADJ
ecj-10810	77	3	editorial	editorial	NOUN
ecj-10810	77	4	from	from	ADP
ecj-10810	77	5	a	a	DET
ecj-10810	77	6	few	few	ADJ
ecj-10810	77	7	years	year	NOUN
ecj-10810	77	8	ago	ago	ADV
ecj-10810	77	9	,	,	PUNCT
ecj-10810	77	10	based	base	VERB
ecj-10810	77	11	on	on	ADP
ecj-10810	77	12	english	english	PROPN
ecj-10810	77	13	data	datum	NOUN
ecj-10810	77	14	,	,	PUNCT
ecj-10810	77	15	points	point	VERB
ecj-10810	77	16	out	out	ADP
ecj-10810	77	17	that	that	DET
ecj-10810	77	18	sepsis	sepsis	NOUN
ecj-10810	77	19	is	be	AUX
ecj-10810	77	20	often	often	ADV
ecj-10810	77	21	the	the	DET
ecj-10810	77	22	terminal	terminal	ADJ
ecj-10810	77	23	event	event	NOUN
ecj-10810	77	24	of	of	ADP
ecj-10810	77	25	a	a	DET
ecj-10810	77	26	severe	severe	ADJ
ecj-10810	77	27	and	and	CCONJ
ecj-10810	77	28	debilitating	debilitate	VERB
ecj-10810	77	29	chronic	chronic	ADJ
ecj-10810	77	30	disease.38	disease.38	PROPN
ecj-10810	77	31	however	however	ADV
ecj-10810	77	32	,	,	PUNCT
ecj-10810	77	33	epidemiological	epidemiological	ADJ
ecj-10810	77	34	data	datum	NOUN
ecj-10810	77	35	suffer	suffer	VERB
ecj-10810	77	36	from	from	ADP
ecj-10810	77	37	important	important	ADJ
ecj-10810	77	38	limitations	limitation	NOUN
ecj-10810	77	39	.	.	PUNCT
ecj-10810	78	1	firstly	firstly	ADV
ecj-10810	78	2	,	,	PUNCT
ecj-10810	78	3	they	they	PRON
ecj-10810	78	4	relate	relate	VERB
ecj-10810	78	5	mostly	mostly	ADV
ecj-10810	78	6	to	to	ADP
ecj-10810	78	7	western	western	ADJ
ecj-10810	78	8	countries	country	NOUN
ecj-10810	78	9	with	with	ADP
ecj-10810	78	10	advanced	advanced	ADJ
ecj-10810	78	11	healthcare	healthcare	NOUN
ecj-10810	78	12	systems	system	NOUN
ecj-10810	78	13	and	and	CCONJ
ecj-10810	78	14	are	be	AUX
ecj-10810	78	15	based	base	VERB
ecj-10810	78	16	mainly	mainly	ADV
ecj-10810	78	17	on	on	ADP
ecj-10810	78	18	registers	register	NOUN
ecj-10810	78	19	of	of	ADP
ecj-10810	78	20	deaths	death	NOUN
ecj-10810	78	21	from	from	ADP
ecj-10810	78	22	the	the	DET
ecj-10810	78	23	hospital	hospital	NOUN
ecj-10810	78	24	settings	setting	NOUN
ecj-10810	78	25	.	.	PUNCT
ecj-10810	79	1	secondly	secondly	ADV
ecj-10810	79	2	,	,	PUNCT
ecj-10810	79	3	following	follow	VERB
ecj-10810	79	4	major	major	ADJ
ecj-10810	79	5	international	international	ADJ
ecj-10810	79	6	initiatives	initiative	NOUN
ecj-10810	79	7	to	to	PART
ecj-10810	79	8	combat	combat	NOUN
ecj-10810	79	9	sepsis	sepsis	NOUN
ecj-10810	79	10	(	(	PUNCT
ecj-10810	79	11	e.g.	e.g.	ADV
ecj-10810	79	12	,	,	PUNCT
ecj-10810	79	13	surviving	survive	VERB
ecj-10810	79	14	sepsis	sepsis	NOUN
ecj-10810	79	15	campaign	campaign	NOUN
ecj-10810	79	16	)	)	PUNCT
ecj-10810	79	17	,	,	PUNCT
ecj-10810	79	18	attention	attention	NOUN
ecj-10810	79	19	to	to	ADP
ecj-10810	79	20	the	the	DET
ecj-10810	79	21	problem	problem	NOUN
ecj-10810	79	22	has	have	AUX
ecj-10810	79	23	increased	increase	VERB
ecj-10810	79	24	and	and	CCONJ
ecj-10810	79	25	many	many	ADJ
ecj-10810	79	26	more	more	ADJ
ecj-10810	79	27	patients	patient	NOUN
ecj-10810	79	28	have	have	AUX
ecj-10810	79	29	been	be	AUX
ecj-10810	79	30	recognized	recognize	VERB
ecj-10810	79	31	as	as	ADP
ecj-10810	79	32	septic	septic	NOUN
ecj-10810	79	33	.	.	PUNCT
ecj-10810	80	1	a	a	DET
ecj-10810	80	2	higher	high	ADJ
ecj-10810	80	3	denominator	denominator	NOUN
ecj-10810	80	4	may	may	AUX
ecj-10810	80	5	therefore	therefore	ADV
ecj-10810	80	6	be	be	AUX
ecj-10810	80	7	responsible	responsible	ADJ
ecj-10810	80	8	for	for	ADP
ecj-10810	80	9	an	an	DET
ecj-10810	80	10	apparent	apparent	ADJ
ecj-10810	80	11	reduction	reduction	NOUN
ecj-10810	80	12	in	in	ADP
ecj-10810	80	13	mortality.39	mortality.39	PROPN
ecj-10810	80	14	to	to	PART
ecj-10810	80	15	better	well	ADV
ecj-10810	80	16	understand	understand	VERB
ecj-10810	80	17	the	the	DET
ecj-10810	80	18	role	role	NOUN
ecj-10810	80	19	that	that	SCONJ
ecj-10810	80	20	fluids	fluid	NOUN
ecj-10810	80	21	and	and	CCONJ
ecj-10810	80	22	vasopressor	vasopressor	NOUN
ecj-10810	80	23	drugs	drug	NOUN
ecj-10810	80	24	have	have	AUX
ecj-10810	80	25	played	play	VERB
ecj-10810	80	26	in	in	ADP
ecj-10810	80	27	improving	improve	VERB
ecj-10810	80	28	mortality	mortality	NOUN
ecj-10810	80	29	from	from	ADP
ecj-10810	80	30	septic	septic	ADJ
ecj-10810	80	31	shock	shock	NOUN
ecj-10810	80	32	,	,	PUNCT
ecj-10810	80	33	it	it	PRON
ecj-10810	80	34	is	be	AUX
ecj-10810	80	35	then	then	ADV
ecj-10810	80	36	necessary	necessary	ADJ
ecj-10810	80	37	to	to	PART
ecj-10810	80	38	examine	examine	VERB
ecj-10810	80	39	the	the	DET
ecj-10810	80	40	results	result	NOUN
ecj-10810	80	41	of	of	ADP
ecj-10810	80	42	clinical	clinical	ADJ
ecj-10810	80	43	trials	trial	NOUN
ecj-10810	80	44	.	.	PUNCT
ecj-10810	81	1	observational	observational	ADJ
ecj-10810	81	2	studies	study	NOUN
ecj-10810	81	3	and	and	CCONJ
ecj-10810	81	4	controlled	control	VERB
ecj-10810	81	5	clinical	clinical	ADJ
ecj-10810	81	6	trials	trial	NOUN
ecj-10810	81	7	fluids	fluid	NOUN
ecj-10810	81	8	most	most	ADJ
ecj-10810	81	9	studies	study	NOUN
ecj-10810	81	10	on	on	ADP
ecj-10810	81	11	fluids	fluid	NOUN
ecj-10810	81	12	in	in	ADP
ecj-10810	81	13	the	the	DET
ecj-10810	81	14	treatment	treatment	NOUN
ecj-10810	81	15	of	of	ADP
ecj-10810	81	16	sepsis	sepsis	NOUN
ecj-10810	81	17	and	and	CCONJ
ecj-10810	81	18	septic	septic	ADJ
ecj-10810	81	19	shock	shock	NOUN
ecj-10810	81	20	are	be	AUX
ecj-10810	81	21	observational	observational	ADJ
ecj-10810	81	22	studies	study	NOUN
ecj-10810	81	23	and	and	CCONJ
ecj-10810	81	24	as	as	ADP
ecj-10810	81	25	such	such	ADJ
ecj-10810	81	26	suffer	suffer	VERB
ecj-10810	81	27	from	from	ADP
ecj-10810	81	28	important	important	ADJ
ecj-10810	81	29	limitations	limitation	NOUN
ecj-10810	81	30	.	.	PUNCT
ecj-10810	82	1	the	the	DET
ecj-10810	82	2	populations	population	NOUN
ecj-10810	82	3	studied	study	VERB
ecj-10810	82	4	are	be	AUX
ecj-10810	82	5	often	often	ADV
ecj-10810	82	6	not	not	PART
ecj-10810	82	7	homogeneous	homogeneous	ADJ
ecj-10810	82	8	with	with	ADP
ecj-10810	82	9	each	each	DET
ecj-10810	82	10	other	other	ADJ
ecj-10810	82	11	(	(	PUNCT
ecj-10810	82	12	in	in	ADP
ecj-10810	82	13	terms	term	NOUN
ecj-10810	82	14	of	of	ADP
ecj-10810	82	15	age	age	NOUN
ecj-10810	82	16	,	,	PUNCT
ecj-10810	82	17	site	site	NOUN
ecj-10810	82	18	of	of	ADP
ecj-10810	82	19	infection	infection	NOUN
ecj-10810	82	20	,	,	PUNCT
ecj-10810	82	21	co	co	NOUN
ecj-10810	82	22	-	-	NOUN
ecj-10810	82	23	pathologies	pathology	NOUN
ecj-10810	82	24	,	,	PUNCT
ecj-10810	82	25	and	and	CCONJ
ecj-10810	82	26	the	the	DET
ecj-10810	82	27	severity	severity	NOUN
ecj-10810	82	28	of	of	ADP
ecj-10810	82	29	septic	septic	ADJ
ecj-10810	82	30	picture	picture	NOUN
ecj-10810	82	31	)	)	PUNCT
ecj-10810	82	32	and	and	CCONJ
ecj-10810	82	33	have	have	AUX
ecj-10810	82	34	been	be	AUX
ecj-10810	82	35	enrolled	enrol	VERB
ecj-10810	82	36	predominantly	predominantly	ADV
ecj-10810	82	37	in	in	ADP
ecj-10810	82	38	intensive	intensive	ADJ
ecj-10810	82	39	care	care	NOUN
ecj-10810	82	40	units	unit	NOUN
ecj-10810	82	41	.	.	PUNCT
ecj-10810	83	1	consequently	consequently	ADV
ecj-10810	83	2	,	,	PUNCT
ecj-10810	83	3	many	many	ADJ
ecj-10810	83	4	studies	study	NOUN
ecj-10810	83	5	exclude	exclude	VERB
ecj-10810	83	6	the	the	DET
ecj-10810	83	7	large	large	ADJ
ecj-10810	83	8	proportion	proportion	NOUN
ecj-10810	83	9	of	of	ADP
ecj-10810	83	10	subjects	subject	NOUN
ecj-10810	83	11	who	who	PRON
ecj-10810	83	12	,	,	PUNCT
ecj-10810	83	13	for	for	ADP
ecj-10810	83	14	various	various	ADJ
ecj-10810	83	15	reasons	reason	NOUN
ecj-10810	83	16	,	,	PUNCT
ecj-10810	83	17	are	be	AUX
ecj-10810	83	18	treated	treat	VERB
ecj-10810	83	19	outside	outside	ADP
ecj-10810	83	20	the	the	DET
ecj-10810	83	21	icu	icu	PROPN
ecj-10810	83	22	and	and	CCONJ
ecj-10810	83	23	who	who	PRON
ecj-10810	83	24	account	account	VERB
ecj-10810	83	25	for	for	ADP
ecj-10810	83	26	most	most	ADJ
ecj-10810	83	27	cases	case	NOUN
ecj-10810	83	28	in	in	ADP
ecj-10810	83	29	daily	daily	ADJ
ecj-10810	83	30	practice	practice	NOUN
ecj-10810	83	31	.	.	PUNCT
ecj-10810	84	1	analysing	analyse	VERB
ecj-10810	84	2	these	these	DET
ecj-10810	84	3	studies	study	NOUN
ecj-10810	84	4	in	in	ADP
ecj-10810	84	5	chronological	chronological	ADJ
ecj-10810	84	6	order	order	NOUN
ecj-10810	84	7	,	,	PUNCT
ecj-10810	84	8	one	one	PRON
ecj-10810	84	9	can	can	AUX
ecj-10810	84	10	recognize	recognize	VERB
ecj-10810	84	11	first	first	ADV
ecj-10810	84	12	of	of	ADP
ecj-10810	84	13	all	all	DET
ecj-10810	84	14	a	a	DET
ecj-10810	84	15	long	long	ADJ
ecj-10810	84	16	series	series	NOUN
ecj-10810	84	17	of	of	ADP
ecj-10810	84	18	papers	paper	NOUN
ecj-10810	84	19	with	with	ADP
ecj-10810	84	20	historical	historical	ADJ
ecj-10810	84	21	controls	control	NOUN
ecj-10810	84	22	that	that	PRON
ecj-10810	84	23	,	,	PUNCT
ecj-10810	84	24	referring	refer	VERB
ecj-10810	84	25	to	to	ADP
ecj-10810	84	26	the	the	DET
ecj-10810	84	27	pivotal	pivotal	ADJ
ecj-10810	84	28	study	study	NOUN
ecj-10810	84	29	by	by	ADP
ecj-10810	84	30	rivers	river	NOUN
ecj-10810	84	31	in	in	ADP
ecj-10810	84	32	2001	2001	NUM
ecj-10810	84	33	(	(	PUNCT
ecj-10810	84	34	see	see	VERB
ecj-10810	84	35	below),40	below),40	NOUN
ecj-10810	84	36	confirm	confirm	VERB
ecj-10810	84	37	that	that	SCONJ
ecj-10810	84	38	patients	patient	NOUN
ecj-10810	84	39	treated	treat	VERB
ecj-10810	84	40	according	accord	VERB
ecj-10810	84	41	to	to	ADP
ecj-10810	84	42	the	the	DET
ecj-10810	84	43	early	early	ADJ
ecj-10810	84	44	goal	goal	NOUN
ecj-10810	84	45	-	-	PUNCT
ecj-10810	84	46	directed	direct	VERB
ecj-10810	84	47	therapy	therapy	NOUN
ecj-10810	84	48	(	(	PUNCT
ecj-10810	84	49	egdt	egdt	ADJ
ecj-10810	84	50	)	)	PUNCT
ecj-10810	84	51	have	have	VERB
ecj-10810	84	52	lower	low	ADJ
ecj-10810	84	53	mortality	mortality	NOUN
ecj-10810	84	54	than	than	ADP
ecj-10810	84	55	patients	patient	NOUN
ecj-10810	84	56	treated	treat	VERB
ecj-10810	84	57	with	with	ADP
ecj-10810	84	58	a	a	DET
ecj-10810	84	59	“	"	PUNCT
ecj-10810	84	60	traditional	traditional	ADJ
ecj-10810	84	61	”	"	PUNCT
ecj-10810	84	62	approach.41	approach.41	NOUN
ecj-10810	84	63	-	-	PUNCT
ecj-10810	84	64	44	44	NUM
ecj-10810	84	65	without	without	ADP
ecj-10810	84	66	going	go	VERB
ecj-10810	84	67	into	into	ADP
ecj-10810	84	68	too	too	ADV
ecj-10810	84	69	much	much	ADJ
ecj-10810	84	70	detail	detail	NOUN
ecj-10810	84	71	,	,	PUNCT
ecj-10810	84	72	suffice	suffice	VERB
ecj-10810	84	73	it	it	PRON
ecj-10810	84	74	to	to	PART
ecj-10810	84	75	say	say	VERB
ecj-10810	84	76	that	that	SCONJ
ecj-10810	84	77	the	the	DET
ecj-10810	84	78	egdt	egdt	ADJ
ecj-10810	84	79	protocol	protocol	NOUN
ecj-10810	84	80	required	require	VERB
ecj-10810	84	81	the	the	DET
ecj-10810	84	82	administration	administration	NOUN
ecj-10810	84	83	of	of	ADP
ecj-10810	84	84	fluids	fluid	NOUN
ecj-10810	84	85	until	until	ADP
ecj-10810	84	86	cvp	cvp	NOUN
ecj-10810	84	87	values	value	NOUN
ecj-10810	84	88	=	=	SYM
ecj-10810	84	89	8	8	NUM
ecj-10810	84	90	-	-	SYM
ecj-10810	84	91	12	12	NUM
ecj-10810	84	92	mmhg	mmhg	NOUN
ecj-10810	84	93	were	be	AUX
ecj-10810	84	94	reached	reach	VERB
ecj-10810	84	95	and	and	CCONJ
ecj-10810	84	96	considered	consider	VERB
ecj-10810	84	97	the	the	DET
ecj-10810	84	98	administration	administration	NOUN
ecj-10810	84	99	of	of	ADP
ecj-10810	84	100	vasopressors	vasopressor	NOUN
ecj-10810	84	101	only	only	ADV
ecj-10810	84	102	after	after	SCONJ
ecj-10810	84	103	this	this	DET
ecj-10810	84	104	step	step	NOUN
ecj-10810	84	105	was	be	AUX
ecj-10810	84	106	completed	complete	VERB
ecj-10810	84	107	.	.	PUNCT
ecj-10810	85	1	an	an	DET
ecj-10810	85	2	adequate	adequate	ADJ
ecj-10810	85	3	central	central	ADJ
ecj-10810	85	4	venous	venous	ADJ
ecj-10810	85	5	saturation	saturation	NOUN
ecj-10810	85	6	was	be	AUX
ecj-10810	85	7	the	the	DET
ecj-10810	85	8	ultimate	ultimate	ADJ
ecj-10810	85	9	review	review	NOUN
ecj-10810	86	1	[	[	X
ecj-10810	86	2	page	page	NOUN
ecj-10810	86	3	12	12	NUM
ecj-10810	86	4	]	]	PUNCT
ecj-10810	87	1	[	[	X
ecj-10810	87	2	emergency	emergency	NOUN
ecj-10810	87	3	care	care	NOUN
ecj-10810	87	4	journal	journal	NOUN
ecj-10810	87	5	2023	2023	NUM
ecj-10810	87	6	;	;	PUNCT
ecj-10810	87	7	19:10810	19:10810	NUM
ecj-10810	87	8	]	]	PUNCT
ecj-10810	87	9	figure	figure	NOUN
ecj-10810	87	10	1	1	NUM
ecj-10810	87	11	.	.	PUNCT
ecj-10810	87	12	frank	frank	ADJ
ecj-10810	87	13	-	-	PUNCT
ecj-10810	87	14	starling	starle	VERB
ecj-10810	87	15	curve	curve	NOUN
ecj-10810	87	16	in	in	ADP
ecj-10810	87	17	the	the	DET
ecj-10810	87	18	normal	normal	ADJ
ecj-10810	87	19	and	and	CCONJ
ecj-10810	87	20	insufficient	insufficient	ADJ
ecj-10810	87	21	heart	heart	NOUN
ecj-10810	87	22	.	.	PUNCT
ecj-10810	88	1	non	non	ADJ
ecj-10810	89	1	-co	-co	PROPN
ecj-10810	89	2	mmerc	mmerc	PROPN
ecj-10810	89	3	ial	ial	PROPN
ecj-10810	89	4	us	us	PROPN
ecj-10810	89	5	e	e	NOUN
ecj-10810	89	6	o	o	NOUN
ecj-10810	89	7	nly	nly	ADV
ecj-10810	89	8	goal	goal	NOUN
ecj-10810	89	9	.	.	PUNCT
ecj-10810	90	1	the	the	DET
ecj-10810	90	2	egdt	egdt	ADJ
ecj-10810	90	3	approach	approach	NOUN
ecj-10810	90	4	was	be	AUX
ecj-10810	90	5	strongly	strongly	ADV
ecj-10810	90	6	criticized	criticize	VERB
ecj-10810	90	7	in	in	ADP
ecj-10810	90	8	later	later	ADV
ecj-10810	90	9	years,4548	years,4548	ADV
ecj-10810	91	1	but	but	CCONJ
ecj-10810	91	2	this	this	PRON
ecj-10810	91	3	did	do	AUX
ecj-10810	91	4	not	not	PART
ecj-10810	91	5	prevent	prevent	VERB
ecj-10810	91	6	it	it	PRON
ecj-10810	91	7	from	from	ADP
ecj-10810	91	8	becoming	become	VERB
ecj-10810	91	9	the	the	DET
ecj-10810	91	10	reference	reference	NOUN
ecj-10810	91	11	for	for	ADP
ecj-10810	91	12	international	international	ADJ
ecj-10810	91	13	guidelines	guideline	NOUN
ecj-10810	91	14	for	for	ADP
ecj-10810	91	15	almost	almost	ADV
ecj-10810	91	16	15	15	NUM
ecj-10810	91	17	years.49	years.49	NOUN
ecj-10810	91	18	in	in	ADP
ecj-10810	91	19	2017	2017	NUM
ecj-10810	91	20	,	,	PUNCT
ecj-10810	91	21	though	though	ADV
ecj-10810	91	22	,	,	PUNCT
ecj-10810	91	23	an	an	DET
ecj-10810	91	24	important	important	ADJ
ecj-10810	91	25	paper	paper	NOUN
ecj-10810	91	26	documented	document	VERB
ecj-10810	91	27	that	that	SCONJ
ecj-10810	91	28	almost	almost	ADV
ecj-10810	91	29	all	all	DET
ecj-10810	91	30	the	the	DET
ecj-10810	91	31	benefits	benefit	NOUN
ecj-10810	91	32	shown	show	VERB
ecj-10810	91	33	by	by	ADP
ecj-10810	91	34	the	the	DET
ecj-10810	91	35	observational	observational	ADJ
ecj-10810	91	36	studies	study	NOUN
ecj-10810	91	37	on	on	ADP
ecj-10810	91	38	egdt	egdt	ADJ
ecj-10810	91	39	could	could	AUX
ecj-10810	91	40	be	be	AUX
ecj-10810	91	41	attributed	attribute	VERB
ecj-10810	91	42	to	to	ADP
ecj-10810	91	43	the	the	DET
ecj-10810	91	44	earlier	early	ADJ
ecj-10810	91	45	administration	administration	NOUN
ecj-10810	91	46	of	of	ADP
ecj-10810	91	47	antibiotic	antibiotic	ADJ
ecj-10810	91	48	treatment	treatment	NOUN
ecj-10810	91	49	,	,	PUNCT
ecj-10810	91	50	a	a	DET
ecj-10810	91	51	likely	likely	ADJ
ecj-10810	91	52	by	by	NOUN
ecj-10810	91	53	-	-	PUNCT
ecj-10810	91	54	product	product	NOUN
ecj-10810	91	55	of	of	ADP
ecj-10810	91	56	the	the	DET
ecj-10810	91	57	growing	grow	VERB
ecj-10810	91	58	attention	attention	NOUN
ecj-10810	91	59	to	to	PART
ecj-10810	91	60	speed	speed	VERB
ecj-10810	91	61	up	up	ADP
ecj-10810	91	62	all	all	DET
ecj-10810	91	63	therapeutic	therapeutic	ADJ
ecj-10810	91	64	interventions.50	interventions.50	PROPN
ecj-10810	91	65	a	a	DET
ecj-10810	91	66	second	second	ADJ
ecj-10810	91	67	set	set	NOUN
ecj-10810	91	68	of	of	ADP
ecj-10810	91	69	observational	observational	ADJ
ecj-10810	91	70	studies	study	NOUN
ecj-10810	91	71	grew	grow	VERB
ecj-10810	91	72	out	out	ADP
ecj-10810	91	73	of	of	ADP
ecj-10810	91	74	concern	concern	NOUN
ecj-10810	91	75	that	that	SCONJ
ecj-10810	91	76	the	the	DET
ecj-10810	91	77	egdt	egdt	ADJ
ecj-10810	91	78	approach	approach	NOUN
ecj-10810	91	79	could	could	AUX
ecj-10810	91	80	lead	lead	VERB
ecj-10810	91	81	to	to	ADP
ecj-10810	91	82	the	the	DET
ecj-10810	91	83	harmful	harmful	ADJ
ecj-10810	91	84	overuse	overuse	NOUN
ecj-10810	91	85	of	of	ADP
ecj-10810	91	86	fluids	fluid	NOUN
ecj-10810	91	87	.	.	PUNCT
ecj-10810	92	1	these	these	DET
ecj-10810	92	2	studies	study	NOUN
ecj-10810	92	3	collectively	collectively	ADV
ecj-10810	92	4	documented	document	VERB
ecj-10810	92	5	that	that	SCONJ
ecj-10810	92	6	a	a	DET
ecj-10810	92	7	positive	positive	ADJ
ecj-10810	92	8	fluid	fluid	NOUN
ecj-10810	92	9	balance	balance	NOUN
ecj-10810	92	10	at	at	ADP
ecj-10810	92	11	12	12	NUM
ecj-10810	92	12	-	-	SYM
ecj-10810	92	13	48	48	NUM
ecj-10810	92	14	hours	hour	NOUN
ecj-10810	92	15	after	after	SCONJ
ecj-10810	92	16	diagnosis	diagnosis	NOUN
ecj-10810	92	17	is	be	AUX
ecj-10810	92	18	associated	associate	VERB
ecj-10810	92	19	with	with	ADP
ecj-10810	92	20	increased	increase	VERB
ecj-10810	92	21	mortality.51,52	mortality.51,52	ADJ
ecj-10810	92	22	other	other	ADJ
ecj-10810	92	23	studies	study	NOUN
ecj-10810	92	24	showed	show	VERB
ecj-10810	92	25	that	that	SCONJ
ecj-10810	92	26	a	a	DET
ecj-10810	92	27	higher	high	ADJ
ecj-10810	92	28	cumulative	cumulative	ADJ
ecj-10810	92	29	fluid	fluid	NOUN
ecj-10810	92	30	balance	balance	NOUN
ecj-10810	92	31	was	be	AUX
ecj-10810	92	32	associated	associate	VERB
ecj-10810	92	33	with	with	ADP
ecj-10810	92	34	the	the	DET
ecj-10810	92	35	subsequent	subsequent	ADJ
ecj-10810	92	36	development	development	NOUN
ecj-10810	92	37	of	of	ADP
ecj-10810	92	38	major	major	ADJ
ecj-10810	92	39	adverse	adverse	ADJ
ecj-10810	92	40	kidney	kidney	NOUN
ecj-10810	92	41	events.53,54	events.53,54	NOUN
ecj-10810	92	42	this	this	DET
ecj-10810	92	43	new	new	ADJ
ecj-10810	92	44	awareness	awareness	NOUN
ecj-10810	92	45	stimulated	stimulate	VERB
ecj-10810	92	46	a	a	DET
ecj-10810	92	47	progressive	progressive	ADJ
ecj-10810	92	48	reversal	reversal	NOUN
ecj-10810	92	49	of	of	ADP
ecj-10810	92	50	fluid	fluid	ADJ
ecj-10810	92	51	administration	administration	NOUN
ecj-10810	92	52	protocols	protocol	NOUN
ecj-10810	92	53	in	in	ADP
ecj-10810	92	54	septic	septic	ADJ
ecj-10810	92	55	shock	shock	NOUN
ecj-10810	92	56	and	and	CCONJ
ecj-10810	92	57	renewed	renew	VERB
ecj-10810	92	58	interest	interest	NOUN
ecj-10810	92	59	in	in	ADP
ecj-10810	92	60	the	the	DET
ecj-10810	92	61	early	early	ADJ
ecj-10810	92	62	administration	administration	NOUN
ecj-10810	92	63	of	of	ADP
ecj-10810	92	64	vasopressor	vasopressor	NOUN
ecj-10810	92	65	drugs	drug	NOUN
ecj-10810	92	66	.	.	PUNCT
ecj-10810	93	1	among	among	ADP
ecj-10810	93	2	randomized	randomized	ADJ
ecj-10810	93	3	clinical	clinical	ADJ
ecj-10810	93	4	trials	trial	NOUN
ecj-10810	93	5	(	(	PUNCT
ecj-10810	93	6	rct	rct	PROPN
ecj-10810	93	7	)	)	PUNCT
ecj-10810	93	8	,	,	PUNCT
ecj-10810	93	9	three	three	NUM
ecj-10810	93	10	large	large	ADJ
ecj-10810	93	11	studies	study	NOUN
ecj-10810	93	12	which	which	PRON
ecj-10810	93	13	challenged	challenge	VERB
ecj-10810	93	14	the	the	DET
ecj-10810	93	15	results	result	NOUN
ecj-10810	93	16	of	of	ADP
ecj-10810	93	17	the	the	DET
ecj-10810	93	18	original	original	ADJ
ecj-10810	93	19	egdt	egdt	ADJ
ecj-10810	93	20	trial	trial	NOUN
ecj-10810	93	21	should	should	AUX
ecj-10810	93	22	be	be	AUX
ecj-10810	93	23	mentioned	mention	VERB
ecj-10810	93	24	,	,	PUNCT
ecj-10810	93	25	if	if	SCONJ
ecj-10810	93	26	only	only	ADV
ecj-10810	93	27	for	for	ADP
ecj-10810	93	28	their	their	PRON
ecj-10810	93	29	size	size	NOUN
ecj-10810	93	30	.	.	PUNCT
ecj-10810	94	1	all	all	DET
ecj-10810	94	2	three	three	NUM
ecj-10810	94	3	studies	study	NOUN
ecj-10810	94	4	(	(	PUNCT
ecj-10810	94	5	arise	arise	NOUN
ecj-10810	94	6	,	,	PUNCT
ecj-10810	94	7	promise	promise	NOUN
ecj-10810	94	8	,	,	PUNCT
ecj-10810	94	9	and	and	CCONJ
ecj-10810	94	10	process)55	process)55	PROPN
ecj-10810	94	11	-	-	SYM
ecj-10810	94	12	57	57	NUM
ecj-10810	94	13	failed	fail	VERB
ecj-10810	94	14	to	to	PART
ecj-10810	94	15	demonstrate	demonstrate	VERB
ecj-10810	94	16	a	a	DET
ecj-10810	94	17	benefit	benefit	NOUN
ecj-10810	94	18	with	with	ADP
ecj-10810	94	19	egdt	egdt	ADJ
ecj-10810	94	20	.	.	PUNCT
ecj-10810	95	1	nevertheless	nevertheless	ADV
ecj-10810	95	2	,	,	PUNCT
ecj-10810	95	3	their	their	PRON
ecj-10810	95	4	results	result	NOUN
ecj-10810	95	5	are	be	AUX
ecj-10810	95	6	difficult	difficult	ADJ
ecj-10810	95	7	to	to	PART
ecj-10810	95	8	interpret	interpret	VERB
ecj-10810	95	9	since	since	SCONJ
ecj-10810	95	10	they	they	PRON
ecj-10810	95	11	were	be	AUX
ecj-10810	95	12	conducted	conduct	VERB
ecj-10810	95	13	about	about	ADP
ecj-10810	95	14	15	15	NUM
ecj-10810	95	15	years	year	NOUN
ecj-10810	95	16	after	after	ADP
ecj-10810	95	17	the	the	DET
ecj-10810	95	18	original	original	ADJ
ecj-10810	95	19	study	study	NOUN
ecj-10810	95	20	by	by	ADP
ecj-10810	95	21	rivers	river	NOUN
ecj-10810	95	22	,	,	PUNCT
ecj-10810	95	23	when	when	SCONJ
ecj-10810	95	24	the	the	DET
ecj-10810	95	25	general	general	ADJ
ecj-10810	95	26	approach	approach	NOUN
ecj-10810	95	27	to	to	ADP
ecj-10810	95	28	septic	septic	ADJ
ecj-10810	95	29	patients	patient	NOUN
ecj-10810	95	30	had	have	AUX
ecj-10810	95	31	already	already	ADV
ecj-10810	95	32	changed	change	VERB
ecj-10810	95	33	profoundly	profoundly	ADV
ecj-10810	95	34	.	.	PUNCT
ecj-10810	96	1	it	it	PRON
ecj-10810	96	2	is	be	AUX
ecj-10810	96	3	important	important	ADJ
ecj-10810	96	4	to	to	PART
ecj-10810	96	5	notice	notice	VERB
ecj-10810	96	6	that	that	SCONJ
ecj-10810	96	7	in	in	ADP
ecj-10810	96	8	all	all	DET
ecj-10810	96	9	egdt	egdt	ADJ
ecj-10810	96	10	studies	study	NOUN
ecj-10810	96	11	,	,	PUNCT
ecj-10810	96	12	patients	patient	NOUN
ecj-10810	96	13	received	receive	VERB
ecj-10810	96	14	more	more	ADJ
ecj-10810	96	15	than	than	ADP
ecj-10810	96	16	2	2	NUM
ecj-10810	96	17	l	l	NOUN
ecj-10810	96	18	of	of	ADP
ecj-10810	96	19	fluids	fluid	NOUN
ecj-10810	96	20	before	before	ADP
ecj-10810	96	21	randomization	randomization	NOUN
ecj-10810	96	22	,	,	PUNCT
ecj-10810	96	23	and	and	CCONJ
ecj-10810	96	24	at	at	ADV
ecj-10810	96	25	least	least	ADV
ecj-10810	96	26	2	2	NUM
ecj-10810	96	27	l	l	NOUN
ecj-10810	96	28	more	more	ADJ
ecj-10810	96	29	during	during	ADP
ecj-10810	96	30	the	the	DET
ecj-10810	96	31	first	first	ADJ
ecj-10810	96	32	6	6	NUM
ecj-10810	96	33	hours	hour	NOUN
ecj-10810	96	34	of	of	ADP
ecj-10810	96	35	treatment	treatment	NOUN
ecj-10810	96	36	(	(	PUNCT
ecj-10810	96	37	table	table	NOUN
ecj-10810	96	38	1	1	NUM
ecj-10810	96	39	)	)	PUNCT
ecj-10810	96	40	.	.	PUNCT
ecj-10810	97	1	more	more	ADV
ecj-10810	97	2	interesting	interesting	ADJ
ecj-10810	97	3	,	,	PUNCT
ecj-10810	97	4	with	with	ADP
ecj-10810	97	5	regard	regard	NOUN
ecj-10810	97	6	to	to	ADP
ecj-10810	97	7	our	our	PRON
ecj-10810	97	8	topic	topic	NOUN
ecj-10810	97	9	,	,	PUNCT
ecj-10810	97	10	are	be	AUX
ecj-10810	97	11	several	several	ADJ
ecj-10810	97	12	smaller	small	ADJ
ecj-10810	97	13	studies	study	NOUN
ecj-10810	97	14	that	that	PRON
ecj-10810	97	15	specifically	specifically	ADV
ecj-10810	97	16	investigated	investigate	VERB
ecj-10810	97	17	the	the	DET
ecj-10810	97	18	amount	amount	NOUN
ecj-10810	97	19	of	of	ADP
ecj-10810	97	20	fluids	fluid	NOUN
ecj-10810	97	21	to	to	PART
ecj-10810	97	22	be	be	AUX
ecj-10810	97	23	given	give	VERB
ecj-10810	97	24	in	in	ADP
ecj-10810	97	25	the	the	DET
ecj-10810	97	26	acute	acute	ADJ
ecj-10810	97	27	phase	phase	NOUN
ecj-10810	97	28	of	of	ADP
ecj-10810	97	29	septic	septic	ADJ
ecj-10810	97	30	shock.58,59	shock.58,59	NOUN
ecj-10810	97	31	most	most	ADJ
ecj-10810	97	32	studies	study	NOUN
ecj-10810	97	33	that	that	SCONJ
ecj-10810	97	34	compared	compare	VERB
ecj-10810	97	35	a	a	DET
ecj-10810	97	36	restrictive	restrictive	ADJ
ecj-10810	97	37	versus	versus	ADP
ecj-10810	97	38	a	a	DET
ecj-10810	97	39	liberal	liberal	ADJ
ecj-10810	97	40	use	use	NOUN
ecj-10810	97	41	of	of	ADP
ecj-10810	97	42	fluids	fluid	NOUN
ecj-10810	97	43	pointed	point	VERB
ecj-10810	97	44	towards	towards	ADP
ecj-10810	97	45	a	a	DET
ecj-10810	97	46	beneficial	beneficial	ADJ
ecj-10810	97	47	effect	effect	NOUN
ecj-10810	97	48	of	of	ADP
ecj-10810	97	49	fluid	fluid	ADJ
ecj-10810	97	50	restriction	restriction	NOUN
ecj-10810	97	51	,	,	PUNCT
ecj-10810	97	52	but	but	CCONJ
ecj-10810	97	53	they	they	PRON
ecj-10810	97	54	were	be	AUX
ecj-10810	97	55	not	not	PART
ecj-10810	97	56	powered	power	VERB
ecj-10810	97	57	to	to	PART
ecj-10810	97	58	reach	reach	VERB
ecj-10810	97	59	statistical	statistical	ADJ
ecj-10810	97	60	significance	significance	NOUN
ecj-10810	97	61	.	.	PUNCT
ecj-10810	98	1	in	in	ADP
ecj-10810	98	2	most	most	ADJ
ecj-10810	98	3	cases	case	NOUN
ecj-10810	98	4	,	,	PUNCT
ecj-10810	98	5	however	however	ADV
ecj-10810	98	6	,	,	PUNCT
ecj-10810	98	7	these	these	DET
ecj-10810	98	8	studies	study	NOUN
ecj-10810	98	9	enrolled	enrol	VERB
ecj-10810	98	10	patients	patient	NOUN
ecj-10810	98	11	who	who	PRON
ecj-10810	98	12	had	have	AUX
ecj-10810	98	13	already	already	ADV
ecj-10810	98	14	been	be	AUX
ecj-10810	98	15	admitted	admit	VERB
ecj-10810	98	16	to	to	ADP
ecj-10810	98	17	the	the	DET
ecj-10810	98	18	icu	icu	PROPN
ecj-10810	98	19	and	and	CCONJ
ecj-10810	98	20	for	for	ADP
ecj-10810	98	21	whom	whom	PRON
ecj-10810	98	22	the	the	DET
ecj-10810	98	23	quantity	quantity	NOUN
ecj-10810	98	24	of	of	ADP
ecj-10810	98	25	fluids	fluid	NOUN
ecj-10810	98	26	administered	administer	VERB
ecj-10810	98	27	before	before	ADP
ecj-10810	98	28	admission	admission	NOUN
ecj-10810	98	29	was	be	AUX
ecj-10810	98	30	not	not	PART
ecj-10810	98	31	always	always	ADV
ecj-10810	98	32	clearly	clearly	ADV
ecj-10810	98	33	reported	report	VERB
ecj-10810	98	34	.	.	PUNCT
ecj-10810	99	1	of	of	ADP
ecj-10810	99	2	particular	particular	ADJ
ecj-10810	99	3	interest	interest	NOUN
ecj-10810	99	4	is	be	AUX
ecj-10810	99	5	a	a	DET
ecj-10810	99	6	pilot	pilot	NOUN
ecj-10810	99	7	study	study	NOUN
ecj-10810	99	8	that	that	PRON
ecj-10810	99	9	enrolled	enrol	VERB
ecj-10810	99	10	patients	patient	NOUN
ecj-10810	99	11	at	at	ADP
ecj-10810	99	12	the	the	DET
ecj-10810	99	13	time	time	NOUN
ecj-10810	99	14	of	of	ADP
ecj-10810	99	15	their	their	PRON
ecj-10810	99	16	arrival	arrival	NOUN
ecj-10810	99	17	at	at	ADP
ecj-10810	99	18	the	the	DET
ecj-10810	99	19	emergency	emergency	NOUN
ecj-10810	99	20	department	department	NOUN
ecj-10810	99	21	.	.	PUNCT
ecj-10810	100	1	in	in	ADP
ecj-10810	100	2	this	this	DET
ecj-10810	100	3	study	study	NOUN
ecj-10810	100	4	,	,	PUNCT
ecj-10810	100	5	patients	patient	NOUN
ecj-10810	100	6	in	in	ADP
ecj-10810	100	7	both	both	DET
ecj-10810	100	8	groups	group	NOUN
ecj-10810	100	9	had	have	AUX
ecj-10810	100	10	received	receive	VERB
ecj-10810	100	11	approximately	approximately	ADV
ecj-10810	100	12	35	35	NUM
ecj-10810	100	13	/	/	SYM
ecj-10810	100	14	ml	ml	NOUN
ecj-10810	100	15	/	/	SYM
ecj-10810	100	16	hg	hg	NOUN
ecj-10810	100	17	of	of	ADP
ecj-10810	100	18	crystalloids	crystalloid	NOUN
ecj-10810	100	19	at	at	ADP
ecj-10810	100	20	the	the	DET
ecj-10810	100	21	time	time	NOUN
ecj-10810	100	22	of	of	ADP
ecj-10810	100	23	enrolment	enrolment	NOUN
ecj-10810	100	24	and	and	CCONJ
ecj-10810	100	25	remained	remain	VERB
ecj-10810	100	26	in	in	ADP
ecj-10810	100	27	shock	shock	NOUN
ecj-10810	100	28	,	,	PUNCT
ecj-10810	100	29	so	so	CCONJ
ecj-10810	100	30	the	the	DET
ecj-10810	100	31	difference	difference	NOUN
ecj-10810	100	32	between	between	ADP
ecj-10810	100	33	the	the	DET
ecj-10810	100	34	two	two	NUM
ecj-10810	100	35	groups	group	NOUN
ecj-10810	100	36	was	be	AUX
ecj-10810	100	37	limited	limit	VERB
ecj-10810	100	38	to	to	ADP
ecj-10810	100	39	the	the	DET
ecj-10810	100	40	hours	hour	NOUN
ecj-10810	100	41	following	follow	VERB
ecj-10810	100	42	randomization	randomization	NOUN
ecj-10810	100	43	.	.	PUNCT
ecj-10810	101	1	patients	patient	NOUN
ecj-10810	101	2	randomized	randomize	VERB
ecj-10810	101	3	to	to	ADP
ecj-10810	101	4	restrictive	restrictive	ADJ
ecj-10810	101	5	treatment	treatment	NOUN
ecj-10810	101	6	received	receive	VERB
ecj-10810	101	7	,	,	PUNCT
ecj-10810	101	8	in	in	ADP
ecj-10810	101	9	the	the	DET
ecj-10810	101	10	first	first	ADJ
ecj-10810	101	11	24	24	NUM
ecj-10810	101	12	hours	hour	NOUN
ecj-10810	101	13	,	,	PUNCT
ecj-10810	101	14	half	half	DET
ecj-10810	101	15	the	the	DET
ecj-10810	101	16	fluids	fluid	NOUN
ecj-10810	101	17	that	that	PRON
ecj-10810	101	18	were	be	AUX
ecj-10810	101	19	administered	administer	VERB
ecj-10810	101	20	to	to	ADP
ecj-10810	101	21	controls	control	NOUN
ecj-10810	101	22	,	,	PUNCT
ecj-10810	101	23	with	with	ADP
ecj-10810	101	24	no	no	DET
ecj-10810	101	25	difference	difference	NOUN
ecj-10810	101	26	in	in	ADP
ecj-10810	101	27	mortality	mortality	NOUN
ecj-10810	101	28	and	and	CCONJ
ecj-10810	101	29	with	with	ADP
ecj-10810	101	30	a	a	DET
ecj-10810	101	31	suggestive	suggestive	ADJ
ecj-10810	101	32	reduction	reduction	NOUN
ecj-10810	101	33	(	(	PUNCT
ecj-10810	101	34	although	although	SCONJ
ecj-10810	101	35	not	not	PART
ecj-10810	101	36	statistically	statistically	ADV
ecj-10810	101	37	significant	significant	ADJ
ecj-10810	101	38	)	)	PUNCT
ecj-10810	101	39	in	in	ADP
ecj-10810	101	40	icu	icu	PROPN
ecj-10810	101	41	stay	stay	NOUN
ecj-10810	101	42	and	and	CCONJ
ecj-10810	101	43	hours	hour	NOUN
ecj-10810	101	44	of	of	ADP
ecj-10810	101	45	mechanical	mechanical	ADJ
ecj-10810	101	46	ventilation	ventilation	NOUN
ecj-10810	101	47	and	and	CCONJ
ecj-10810	101	48	amine	amine	ADJ
ecj-10810	101	49	administration	administration	NOUN
ecj-10810	101	50	.	.	PUNCT
ecj-10810	102	1	it	it	PRON
ecj-10810	102	2	must	must	AUX
ecj-10810	102	3	be	be	AUX
ecj-10810	102	4	emphasized	emphasize	VERB
ecj-10810	102	5	,	,	PUNCT
ecj-10810	102	6	however	however	ADV
ecj-10810	102	7	,	,	PUNCT
ecj-10810	102	8	that	that	SCONJ
ecj-10810	102	9	in	in	ADP
ecj-10810	102	10	this	this	DET
ecj-10810	102	11	study	study	NOUN
ecj-10810	102	12	patients	patient	NOUN
ecj-10810	102	13	both	both	CCONJ
ecj-10810	102	14	in	in	ADP
ecj-10810	102	15	the	the	DET
ecj-10810	102	16	treated	treat	VERB
ecj-10810	102	17	and	and	CCONJ
ecj-10810	102	18	in	in	ADP
ecj-10810	102	19	the	the	DET
ecj-10810	102	20	control	control	NOUN
ecj-10810	102	21	group	group	NOUN
ecj-10810	102	22	received	receive	VERB
ecj-10810	102	23	much	much	ADV
ecj-10810	102	24	less	less	ADJ
ecj-10810	102	25	fluid	fluid	NOUN
ecj-10810	102	26	(	(	PUNCT
ecj-10810	102	27	respectively	respectively	ADV
ecj-10810	102	28	7.8	7.8	NUM
ecj-10810	102	29	±	±	NUM
ecj-10810	102	30	13.3	13.3	NUM
ecj-10810	102	31	and	and	CCONJ
ecj-10810	102	32	16.6	16.6	NUM
ecj-10810	102	33	±	±	NUM
ecj-10810	102	34	23.2	23.2	NUM
ecj-10810	102	35	ml	ml	NOUN
ecj-10810	102	36	/	/	SYM
ecj-10810	102	37	kg	kg	PROPN
ecj-10810	102	38	in	in	ADP
ecj-10810	102	39	the	the	DET
ecj-10810	102	40	first	first	ADJ
ecj-10810	102	41	24	24	NUM
ecj-10810	102	42	hours	hour	NOUN
ecj-10810	102	43	)	)	PUNCT
ecj-10810	102	44	than	than	ADP
ecj-10810	102	45	in	in	ADP
ecj-10810	102	46	each	each	PRON
ecj-10810	102	47	of	of	ADP
ecj-10810	102	48	the	the	DET
ecj-10810	102	49	four	four	NUM
ecj-10810	102	50	randomized	randomized	ADJ
ecj-10810	102	51	egdt	egdt	ADJ
ecj-10810	102	52	studies	study	NOUN
ecj-10810	102	53	(	(	PUNCT
ecj-10810	102	54	table	table	NOUN
ecj-10810	102	55	1	1	NUM
ecj-10810	102	56	)	)	PUNCT
ecj-10810	102	57	.	.	PUNCT
ecj-10810	103	1	two	two	NUM
ecj-10810	103	2	recent	recent	ADJ
ecj-10810	103	3	,	,	PUNCT
ecj-10810	103	4	randomized	randomize	VERB
ecj-10810	103	5	studies	study	NOUN
ecj-10810	103	6	of	of	ADP
ecj-10810	103	7	adequate	adequate	ADJ
ecj-10810	103	8	numerosity	numerosity	NOUN
ecj-10810	103	9	have	have	AUX
ecj-10810	103	10	given	give	VERB
ecj-10810	103	11	a	a	DET
ecj-10810	103	12	very	very	ADV
ecj-10810	103	13	important	important	ADJ
ecj-10810	103	14	contribution	contribution	NOUN
ecj-10810	103	15	to	to	ADP
ecj-10810	103	16	settling	settle	VERB
ecj-10810	103	17	the	the	DET
ecj-10810	103	18	problem	problem	NOUN
ecj-10810	103	19	since	since	SCONJ
ecj-10810	103	20	neither	neither	CCONJ
ecj-10810	103	21	demonstrated	demonstrate	VERB
ecj-10810	103	22	any	any	DET
ecj-10810	103	23	clinically	clinically	ADV
ecj-10810	103	24	significant	significant	ADJ
ecj-10810	103	25	advantage	advantage	NOUN
ecj-10810	103	26	(	(	PUNCT
ecj-10810	103	27	or	or	CCONJ
ecj-10810	103	28	disadvantage	disadvantage	NOUN
ecj-10810	103	29	)	)	PUNCT
ecj-10810	103	30	for	for	ADP
ecj-10810	103	31	patients	patient	NOUN
ecj-10810	103	32	treated	treat	VERB
ecj-10810	103	33	with	with	ADP
ecj-10810	103	34	a	a	DET
ecj-10810	103	35	restrictive	restrictive	ADJ
ecj-10810	103	36	fluid	fluid	NOUN
ecj-10810	103	37	approach.60,61	approach.60,61	NOUN
ecj-10810	103	38	considering	consider	VERB
ecj-10810	103	39	that	that	SCONJ
ecj-10810	103	40	in	in	ADP
ecj-10810	103	41	both	both	DET
ecj-10810	103	42	studies	study	NOUN
ecj-10810	103	43	patients	patient	NOUN
ecj-10810	103	44	had	have	AUX
ecj-10810	103	45	received	receive	VERB
ecj-10810	103	46	1	1	NUM
ecj-10810	103	47	to	to	PART
ecj-10810	103	48	3	3	NUM
ecj-10810	103	49	l	l	NOUN
ecj-10810	103	50	crystalloids	crystalloid	NOUN
ecj-10810	103	51	before	before	ADP
ecj-10810	103	52	randomization	randomization	NOUN
ecj-10810	103	53	,	,	PUNCT
ecj-10810	103	54	the	the	DET
ecj-10810	103	55	message	message	NOUN
ecj-10810	103	56	seems	seem	VERB
ecj-10810	103	57	to	to	PART
ecj-10810	103	58	be	be	AUX
ecj-10810	103	59	that	that	SCONJ
ecj-10810	103	60	after	after	ADP
ecj-10810	103	61	an	an	DET
ecj-10810	103	62	initial	initial	ADJ
ecj-10810	103	63	resuscitative	resuscitative	NOUN
ecj-10810	103	64	bolus	bolus	NOUN
ecj-10810	103	65	,	,	PUNCT
ecj-10810	103	66	and	and	CCONJ
ecj-10810	103	67	as	as	ADV
ecj-10810	103	68	far	far	ADV
ecj-10810	103	69	as	as	SCONJ
ecj-10810	103	70	the	the	DET
ecj-10810	103	71	first	first	ADJ
ecj-10810	103	72	24	24	NUM
ecj-10810	103	73	hrs	hrs	NOUN
ecj-10810	103	74	of	of	ADP
ecj-10810	103	75	treatment	treatment	NOUN
ecj-10810	103	76	are	be	AUX
ecj-10810	103	77	concerned	concern	VERB
ecj-10810	103	78	,	,	PUNCT
ecj-10810	103	79	the	the	DET
ecj-10810	103	80	amount	amount	NOUN
ecj-10810	103	81	of	of	ADP
ecj-10810	103	82	fluids	fluid	NOUN
ecj-10810	103	83	administered	administer	VERB
ecj-10810	103	84	is	be	AUX
ecj-10810	103	85	not	not	PART
ecj-10810	103	86	such	such	DET
ecj-10810	103	87	an	an	DET
ecj-10810	103	88	important	important	ADJ
ecj-10810	103	89	determinant	determinant	NOUN
ecj-10810	103	90	of	of	ADP
ecj-10810	103	91	outcome	outcome	NOUN
ecj-10810	103	92	.	.	PUNCT
ecj-10810	104	1	the	the	DET
ecj-10810	104	2	surviving	survive	VERB
ecj-10810	104	3	sepsis	sepsis	NOUN
ecj-10810	104	4	campaign	campaign	NOUN
ecj-10810	104	5	guidelines	guideline	NOUN
ecj-10810	104	6	recommend	recommend	VERB
ecj-10810	104	7	initiating	initiate	VERB
ecj-10810	104	8	30	30	NUM
ecj-10810	104	9	ml	ml	NOUN
ecj-10810	104	10	/	/	SYM
ecj-10810	104	11	kg	kg	PROPN
ecj-10810	104	12	of	of	ADP
ecj-10810	104	13	iv	iv	NUM
ecj-10810	104	14	crystalloids	crystalloid	NOUN
ecj-10810	104	15	to	to	ADP
ecj-10810	104	16	patients	patient	NOUN
ecj-10810	104	17	with	with	ADP
ecj-10810	104	18	suspected	suspect	VERB
ecj-10810	104	19	sepsis	sepsis	NOUN
ecj-10810	104	20	within	within	ADP
ecj-10810	104	21	1	1	NUM
ecj-10810	104	22	-	-	SYM
ecj-10810	104	23	3	3	NUM
ecj-10810	104	24	hours	hour	NOUN
ecj-10810	104	25	in	in	ADP
ecj-10810	104	26	case	case	NOUN
ecj-10810	104	27	of	of	ADP
ecj-10810	104	28	hypotension	hypotension	NOUN
ecj-10810	104	29	or	or	CCONJ
ecj-10810	104	30	lactate	lactate	NOUN
ecj-10810	104	31	level	level	NOUN
ecj-10810	104	32	greater	great	ADJ
ecj-10810	104	33	than	than	ADP
ecj-10810	104	34	or	or	CCONJ
ecj-10810	104	35	equal	equal	ADJ
ecj-10810	104	36	to	to	ADP
ecj-10810	104	37	4	4	NUM
ecj-10810	104	38	µmol	µmol	ADV
ecj-10810	104	39	/	/	SYM
ecj-10810	104	40	l.	l.	NOUN
ecj-10810	104	41	although	although	SCONJ
ecj-10810	104	42	this	this	PRON
ecj-10810	104	43	is	be	AUX
ecj-10810	104	44	a	a	DET
ecj-10810	104	45	strong	strong	ADJ
ecj-10810	104	46	recommendation	recommendation	NOUN
ecj-10810	104	47	,	,	PUNCT
ecj-10810	104	48	it	it	PRON
ecj-10810	104	49	is	be	AUX
ecj-10810	104	50	based	base	VERB
ecj-10810	104	51	upon	upon	SCONJ
ecj-10810	104	52	evidence	evidence	NOUN
ecj-10810	104	53	of	of	ADP
ecj-10810	104	54	low	low	ADJ
ecj-10810	104	55	quality	quality	NOUN
ecj-10810	104	56	.	.	PUNCT
ecj-10810	105	1	moreover	moreover	ADV
ecj-10810	105	2	,	,	PUNCT
ecj-10810	105	3	specific	specific	ADJ
ecj-10810	105	4	subpopulations	subpopulation	NOUN
ecj-10810	105	5	might	might	AUX
ecj-10810	105	6	need	need	VERB
ecj-10810	105	7	different	different	ADJ
ecj-10810	105	8	approaches	approach	NOUN
ecj-10810	105	9	.	.	PUNCT
ecj-10810	106	1	for	for	ADP
ecj-10810	106	2	instance	instance	NOUN
ecj-10810	106	3	,	,	PUNCT
ecj-10810	106	4	patients	patient	NOUN
ecj-10810	106	5	with	with	ADP
ecj-10810	106	6	hypotension	hypotension	NOUN
ecj-10810	106	7	but	but	CCONJ
ecj-10810	106	8	normal	normal	ADJ
ecj-10810	106	9	lactate	lactate	NOUN
ecj-10810	106	10	(	(	PUNCT
ecj-10810	106	11	which	which	PRON
ecj-10810	106	12	should	should	AUX
ecj-10810	106	13	not	not	PART
ecj-10810	106	14	be	be	AUX
ecj-10810	106	15	considered	consider	VERB
ecj-10810	106	16	in	in	ADP
ecj-10810	106	17	septic	septic	ADJ
ecj-10810	106	18	shock	shock	NOUN
ecj-10810	106	19	according	accord	VERB
ecj-10810	106	20	to	to	ADP
ecj-10810	106	21	the	the	DET
ecj-10810	106	22	sepsis	sepsis	NOUN
ecj-10810	106	23	3	3	NUM
ecj-10810	106	24	definitions	definition	NOUN
ecj-10810	106	25	)	)	PUNCT
ecj-10810	106	26	have	have	VERB
ecj-10810	106	27	a	a	DET
ecj-10810	106	28	better	well	ADJ
ecj-10810	106	29	outcome	outcome	NOUN
ecj-10810	106	30	and	and	CCONJ
ecj-10810	106	31	might	might	AUX
ecj-10810	106	32	need	need	VERB
ecj-10810	106	33	a	a	DET
ecj-10810	106	34	less	less	ADV
ecj-10810	106	35	aggressive	aggressive	ADJ
ecj-10810	106	36	approach.62	approach.62	NOUN
ecj-10810	106	37	on	on	ADP
ecj-10810	106	38	the	the	DET
ecj-10810	106	39	other	other	ADJ
ecj-10810	106	40	hand	hand	NOUN
ecj-10810	106	41	,	,	PUNCT
ecj-10810	106	42	studies	study	NOUN
ecj-10810	106	43	aiming	aim	VERB
ecj-10810	106	44	to	to	PART
ecj-10810	106	45	normalize	normalize	VERB
ecj-10810	106	46	lactate	lactate	NOUN
ecj-10810	106	47	levels	level	NOUN
ecj-10810	106	48	in	in	ADP
ecj-10810	106	49	normotensive	normotensive	ADJ
ecj-10810	106	50	patients	patient	NOUN
ecj-10810	106	51	have	have	AUX
ecj-10810	106	52	given	give	VERB
ecj-10810	106	53	conflicting	conflicting	ADJ
ecj-10810	106	54	results.63,64	results.63,64	NOUN
ecj-10810	106	55	in	in	ADP
ecj-10810	106	56	clinical	clinical	ADJ
ecj-10810	106	57	practice	practice	NOUN
ecj-10810	106	58	,	,	PUNCT
ecj-10810	106	59	determining	determine	VERB
ecj-10810	106	60	the	the	DET
ecj-10810	106	61	optimal	optimal	ADJ
ecj-10810	106	62	amount	amount	NOUN
ecj-10810	106	63	of	of	ADP
ecj-10810	106	64	fluid	fluid	NOUN
ecj-10810	106	65	to	to	PART
ecj-10810	106	66	be	be	AUX
ecj-10810	106	67	administered	administer	VERB
ecj-10810	106	68	remains	remain	VERB
ecj-10810	106	69	a	a	DET
ecj-10810	106	70	critical	critical	ADJ
ecj-10810	106	71	issue	issue	NOUN
ecj-10810	106	72	that	that	PRON
ecj-10810	106	73	might	might	AUX
ecj-10810	106	74	never	never	ADV
ecj-10810	106	75	find	find	VERB
ecj-10810	106	76	a	a	DET
ecj-10810	106	77	solution	solution	NOUN
ecj-10810	106	78	appropriate	appropriate	ADJ
ecj-10810	106	79	for	for	ADP
ecj-10810	106	80	every	every	DET
ecj-10810	106	81	case.64	case.64	NOUN
ecj-10810	106	82	there	there	PRON
ecj-10810	106	83	is	be	VERB
ecj-10810	106	84	growing	grow	VERB
ecj-10810	106	85	agreement	agreement	NOUN
ecj-10810	106	86	that	that	PRON
ecj-10810	106	87	a	a	DET
ecj-10810	106	88	four	four	NUM
ecj-10810	106	89	-	-	PUNCT
ecj-10810	106	90	step	step	NOUN
ecj-10810	106	91	protocol	protocol	NOUN
ecj-10810	106	92	(	(	PUNCT
ecj-10810	106	93	figure	figure	NOUN
ecj-10810	106	94	2	2	NUM
ecj-10810	106	95	)	)	PUNCT
ecj-10810	106	96	should	should	AUX
ecj-10810	106	97	be	be	AUX
ecj-10810	106	98	adopted	adopt	VERB
ecj-10810	106	99	in	in	ADP
ecj-10810	106	100	most	most	ADJ
ecj-10810	106	101	situations	situation	NOUN
ecj-10810	106	102	,	,	PUNCT
ecj-10810	106	103	with	with	ADP
ecj-10810	106	104	an	an	DET
ecj-10810	106	105	aggressive	aggressive	ADJ
ecj-10810	106	106	initial	initial	ADJ
ecj-10810	106	107	approach	approach	NOUN
ecj-10810	106	108	,	,	PUNCT
ecj-10810	106	109	followed	follow	VERB
ecj-10810	106	110	by	by	ADP
ecj-10810	106	111	optimization	optimization	NOUN
ecj-10810	106	112	and	and	CCONJ
ecj-10810	106	113	quick	quick	ADJ
ecj-10810	106	114	reduction	reduction	NOUN
ecj-10810	106	115	in	in	ADP
ecj-10810	106	116	the	the	DET
ecj-10810	106	117	subsequent	subsequent	ADJ
ecj-10810	106	118	hours	hour	NOUN
ecj-10810	106	119	and	and	CCONJ
ecj-10810	106	120	days.65,66	days.65,66	VERB
ecj-10810	106	121	vasopressors	vasopressor	NOUN
ecj-10810	106	122	studies	study	NOUN
ecj-10810	106	123	on	on	ADP
ecj-10810	106	124	vasopressors	vasopressor	NOUN
ecj-10810	106	125	are	be	AUX
ecj-10810	106	126	far	far	ADV
ecj-10810	106	127	fewer	few	ADJ
ecj-10810	106	128	in	in	ADP
ecj-10810	106	129	number	number	NOUN
ecj-10810	106	130	and	and	CCONJ
ecj-10810	106	131	even	even	ADV
ecj-10810	106	132	less	less	ADV
ecj-10810	106	133	conclusive	conclusive	ADJ
ecj-10810	106	134	than	than	ADP
ecj-10810	106	135	those	those	PRON
ecj-10810	106	136	on	on	ADP
ecj-10810	106	137	volemic	volemic	ADJ
ecj-10810	106	138	replenishment	replenishment	NOUN
ecj-10810	106	139	.	.	PUNCT
ecj-10810	107	1	as	as	ADP
ecj-10810	107	2	in	in	ADP
ecj-10810	107	3	the	the	DET
ecj-10810	107	4	case	case	NOUN
ecj-10810	107	5	of	of	ADP
ecj-10810	107	6	fluids	fluid	NOUN
ecj-10810	107	7	,	,	PUNCT
ecj-10810	107	8	there	there	PRON
ecj-10810	107	9	are	be	VERB
ecj-10810	107	10	no	no	DET
ecj-10810	107	11	clinical	clinical	ADJ
ecj-10810	107	12	studies	study	NOUN
ecj-10810	107	13	comparing	compare	VERB
ecj-10810	107	14	patients	patient	NOUN
ecj-10810	107	15	treated	treat	VERB
ecj-10810	107	16	or	or	CCONJ
ecj-10810	107	17	untreated	untreate	VERB
ecj-10810	107	18	with	with	ADP
ecj-10810	107	19	vasopressors	vasopressor	NOUN
ecj-10810	107	20	,	,	PUNCT
ecj-10810	107	21	but	but	CCONJ
ecj-10810	107	22	only	only	ADV
ecj-10810	107	23	comparisons	comparison	NOUN
ecj-10810	107	24	between	between	ADP
ecj-10810	107	25	different	different	ADJ
ecj-10810	107	26	drugs	drug	NOUN
ecj-10810	107	27	and	and	CCONJ
ecj-10810	107	28	timing	timing	NOUN
ecj-10810	107	29	of	of	ADP
ecj-10810	107	30	treatment	treatment	NOUN
ecj-10810	107	31	.	.	PUNCT
ecj-10810	108	1	noradrenaline	noradrenaline	PROPN
ecj-10810	108	2	is	be	AUX
ecj-10810	108	3	the	the	DET
ecj-10810	108	4	drug	drug	NOUN
ecj-10810	108	5	of	of	ADP
ecj-10810	108	6	choice	choice	NOUN
ecj-10810	108	7	according	accord	VERB
ecj-10810	108	8	to	to	ADP
ecj-10810	108	9	the	the	DET
ecj-10810	108	10	surviving	survive	VERB
ecj-10810	108	11	sepsis	sepsis	NOUN
ecj-10810	108	12	campaign	campaign	NOUN
ecj-10810	108	13	guidelines	guideline	NOUN
ecj-10810	108	14	and	and	CCONJ
ecj-10810	108	15	this	this	DET
ecj-10810	108	16	advice	advice	NOUN
ecj-10810	108	17	is	be	AUX
ecj-10810	108	18	compatible	compatible	ADJ
ecj-10810	108	19	with	with	ADP
ecj-10810	108	20	available	available	ADJ
ecj-10810	108	21	data	datum	NOUN
ecj-10810	108	22	on	on	ADP
ecj-10810	108	23	the	the	DET
ecj-10810	108	24	efficacy	efficacy	NOUN
ecj-10810	108	25	and	and	CCONJ
ecj-10810	108	26	side	side	NOUN
ecj-10810	108	27	effects	effect	NOUN
ecj-10810	108	28	of	of	ADP
ecj-10810	108	29	different	different	ADJ
ecj-10810	108	30	vasopressors.67	vasopressors.67	PROPN
ecj-10810	108	31	vasopressin	vasopressin	NOUN
ecj-10810	108	32	has	have	AUX
ecj-10810	108	33	also	also	ADV
ecj-10810	108	34	been	be	AUX
ecj-10810	108	35	studied	study	VERB
ecj-10810	108	36	as	as	ADP
ecj-10810	108	37	an	an	DET
ecj-10810	108	38	adjunctive	adjunctive	ADJ
ecj-10810	108	39	treatment	treatment	NOUN
ecj-10810	108	40	or	or	CCONJ
ecj-10810	108	41	first	first	ADJ
ecj-10810	108	42	-	-	PUNCT
ecj-10810	108	43	line	line	NOUN
ecj-10810	108	44	therapy	therapy	NOUN
ecj-10810	108	45	,	,	PUNCT
ecj-10810	108	46	with	with	ADP
ecj-10810	108	47	uneven	uneven	ADJ
ecj-10810	108	48	results	result	NOUN
ecj-10810	108	49	.	.	PUNCT
ecj-10810	109	1	as	as	ADP
ecj-10810	109	2	to	to	ADP
ecj-10810	109	3	the	the	DET
ecj-10810	109	4	timing	timing	NOUN
ecj-10810	109	5	of	of	ADP
ecj-10810	109	6	administration	administration	NOUN
ecj-10810	109	7	,	,	PUNCT
ecj-10810	109	8	provisional	provisional	ADJ
ecj-10810	109	9	conclusions	conclusion	NOUN
ecj-10810	109	10	from	from	ADP
ecj-10810	109	11	the	the	DET
ecj-10810	109	12	scanty	scanty	ADJ
ecj-10810	109	13	available	available	ADJ
ecj-10810	109	14	evidence	evidence	NOUN
ecj-10810	109	15	can	can	AUX
ecj-10810	109	16	be	be	AUX
ecj-10810	109	17	summarized	summarize	VERB
ecj-10810	109	18	by	by	ADP
ecj-10810	109	19	saying	say	VERB
ecj-10810	109	20	that	that	SCONJ
ecj-10810	109	21	early	early	ADJ
ecj-10810	109	22	treatment	treatment	NOUN
ecj-10810	109	23	with	with	ADP
ecj-10810	109	24	vasopressors	vasopressor	NOUN
ecj-10810	109	25	(	(	PUNCT
ecj-10810	109	26	<	<	X
ecj-10810	109	27	2h	2h	NUM
ecj-10810	109	28	from	from	ADP
ecj-10810	109	29	the	the	DET
ecj-10810	109	30	onset	onset	NOUN
ecj-10810	109	31	of	of	ADP
ecj-10810	109	32	shock	shock	NOUN
ecj-10810	109	33	)	)	PUNCT
ecj-10810	109	34	seems	seem	VERB
ecj-10810	109	35	to	to	PART
ecj-10810	109	36	be	be	AUX
ecj-10810	109	37	associated	associate	VERB
ecj-10810	109	38	with	with	ADP
ecj-10810	109	39	review	review	NOUN
ecj-10810	109	40	table	table	NOUN
ecj-10810	109	41	1	1	NUM
ecj-10810	109	42	.	.	PUNCT
ecj-10810	109	43	fluid	fluid	ADJ
ecj-10810	109	44	administration	administration	NOUN
ecj-10810	109	45	in	in	ADP
ecj-10810	109	46	the	the	DET
ecj-10810	109	47	4	4	NUM
ecj-10810	109	48	randomized	randomized	ADJ
ecj-10810	109	49	trials	trial	NOUN
ecj-10810	109	50	on	on	ADP
ecj-10810	109	51	egdt	egdt	ADJ
ecj-10810	109	52	.	.	PUNCT
ecj-10810	110	1	fluids	fluid	NOUN
ecj-10810	110	2	(	(	PUNCT
ecj-10810	110	3	ml	ml	NOUN
ecj-10810	110	4	)	)	PUNCT
ecj-10810	110	5	rivers	river	NOUN
ecj-10810	110	6	(	(	PUNCT
ecj-10810	110	7	2001	2001	NUM
ecj-10810	110	8	)	)	PUNCT
ecj-10810	110	9	arise	arise	NOUN
ecj-10810	110	10	(	(	PUNCT
ecj-10810	110	11	2014	2014	NUM
ecj-10810	110	12	)	)	PUNCT
ecj-10810	110	13	process	process	NOUN
ecj-10810	110	14	(	(	PUNCT
ecj-10810	110	15	2014	2014	NUM
ecj-10810	110	16	)	)	PUNCT
ecj-10810	110	17	promise	promise	NOUN
ecj-10810	110	18	(	(	PUNCT
ecj-10810	110	19	2015	2015	NUM
ecj-10810	110	20	)	)	PUNCT
ecj-10810	110	21	pre	pre	ADJ
ecj-10810	110	22	-	-	ADJ
ecj-10810	110	23	random	random	ADJ
ecj-10810	110	24	?	?	PUNCT
ecj-10810	111	1	2515±1244	2515±1244	PROPN
ecj-10810	111	2	2254±1472	2254±1472	NUM
ecj-10810	111	3	1950	1950	NUM
ecj-10810	111	4	0	0	NUM
ecj-10810	111	5	-	-	SYM
ecj-10810	111	6	6h	6h	NUM
ecj-10810	111	7	4981±2984	4981±2984	PROPN
ecj-10810	111	8	2226±1363	2226±1363	NUM
ecj-10810	111	9	2805±1957	2805±1957	NOUN
ecj-10810	111	10	2000	2000	NUM
ecj-10810	111	11	6	6	NUM
ecj-10810	111	12	-	-	SYM
ecj-10810	111	13	72	72	NUM
ecj-10810	111	14	8625±5162	8625±5162	NUM
ecj-10810	111	15	4274±3071	4274±3071	PROPN
ecj-10810	112	1	4458±3878	4458±3878	PROPN
ecj-10810	112	2	3623	3623	NUM
ecj-10810	112	3	total	total	ADJ
ecj-10810	112	4	13606±8146	13606±8146	PROPN
ecj-10810	112	5	8753±5730	8753±5730	PROPN
ecj-10810	112	6	9517±7307	9517±7307	NUM
ecj-10810	112	7	7573	7573	NUM
ecj-10810	113	1	[	[	X
ecj-10810	113	2	emergency	emergency	NOUN
ecj-10810	113	3	care	care	NOUN
ecj-10810	113	4	journal	journal	NOUN
ecj-10810	113	5	2023	2023	NUM
ecj-10810	113	6	;	;	PUNCT
ecj-10810	113	7	19:10810	19:10810	NUM
ecj-10810	113	8	]	]	X
ecj-10810	113	9	[	[	X
ecj-10810	113	10	page	page	NOUN
ecj-10810	113	11	13	13	NUM
ecj-10810	113	12	]	]	PUNCT
ecj-10810	113	13	figure	figure	NOUN
ecj-10810	113	14	2	2	NUM
ecj-10810	113	15	.	.	NUM
ecj-10810	113	16	four	four	NUM
ecj-10810	113	17	-	-	PUNCT
ecj-10810	113	18	step	step	NOUN
ecj-10810	113	19	approach	approach	NOUN
ecj-10810	113	20	to	to	ADP
ecj-10810	113	21	fluid	fluid	ADJ
ecj-10810	113	22	administration	administration	NOUN
ecj-10810	113	23	in	in	ADP
ecj-10810	113	24	shock	shock	NOUN
ecj-10810	113	25	.	.	PUNCT
ecj-10810	114	1	non	non	ADJ
ecj-10810	115	1	-co	-co	PROPN
ecj-10810	115	2	mmerc	mmerc	PROPN
ecj-10810	115	3	ial	ial	PROPN
ecj-10810	115	4	us	us	PROPN
ecj-10810	115	5	e	e	NOUN
ecj-10810	115	6	o	o	X
ecj-10810	115	7	nly	nly	ADV
ecj-10810	115	8	a	a	DET
ecj-10810	115	9	more	more	ADV
ecj-10810	115	10	favorable	favorable	ADJ
ecj-10810	115	11	prognosis.68,69	prognosis.68,69	NOUN
ecj-10810	115	12	an	an	DET
ecj-10810	115	13	interesting	interesting	ADJ
ecj-10810	115	14	retrospective	retrospective	ADJ
ecj-10810	115	15	large	large	ADJ
ecj-10810	115	16	study	study	NOUN
ecj-10810	115	17	suggests	suggest	VERB
ecj-10810	115	18	that	that	SCONJ
ecj-10810	115	19	the	the	DET
ecj-10810	115	20	best	good	ADJ
ecj-10810	115	21	effect	effect	NOUN
ecj-10810	115	22	of	of	ADP
ecj-10810	115	23	vasoactive	vasoactive	ADJ
ecj-10810	115	24	amines	amine	NOUN
ecj-10810	115	25	can	can	AUX
ecj-10810	115	26	be	be	AUX
ecj-10810	115	27	obtained	obtain	VERB
ecj-10810	115	28	by	by	ADP
ecj-10810	115	29	starting	start	VERB
ecj-10810	115	30	their	their	PRON
ecj-10810	115	31	administration	administration	NOUN
ecj-10810	115	32	no	no	ADV
ecj-10810	115	33	earlier	early	ADV
ecj-10810	115	34	than	than	ADP
ecj-10810	115	35	1	1	NUM
ecj-10810	115	36	hour	hour	NOUN
ecj-10810	115	37	and	and	CCONJ
ecj-10810	115	38	no	no	ADV
ecj-10810	115	39	later	later	ADV
ecj-10810	115	40	than	than	ADP
ecj-10810	115	41	6	6	NUM
ecj-10810	115	42	hours	hour	NOUN
ecj-10810	115	43	after	after	ADP
ecj-10810	115	44	the	the	DET
ecj-10810	115	45	diagnosis	diagnosis	NOUN
ecj-10810	115	46	and	and	CCONJ
ecj-10810	115	47	following	follow	VERB
ecj-10810	115	48	an	an	DET
ecj-10810	115	49	initial	initial	ADJ
ecj-10810	115	50	fluid	fluid	ADJ
ecj-10810	115	51	replenishment	replenishment	NOUN
ecj-10810	115	52	of	of	ADP
ecj-10810	115	53	at	at	ADV
ecj-10810	115	54	least	least	ADV
ecj-10810	115	55	1000	1000	NUM
ecj-10810	115	56	ml.70	ml.70	NOUN
ecj-10810	115	57	other	other	ADJ
ecj-10810	115	58	studies	study	NOUN
ecj-10810	115	59	document	document	NOUN
ecj-10810	115	60	that	that	SCONJ
ecj-10810	115	61	higher	high	ADJ
ecj-10810	115	62	doses	dose	NOUN
ecj-10810	115	63	or	or	CCONJ
ecj-10810	115	64	a	a	DET
ecj-10810	115	65	more	more	ADV
ecj-10810	115	66	protracted	protracted	ADJ
ecj-10810	115	67	time	time	NOUN
ecj-10810	115	68	of	of	ADP
ecj-10810	115	69	treatment	treatment	NOUN
ecj-10810	115	70	are	be	AUX
ecj-10810	115	71	associated	associate	VERB
ecj-10810	115	72	with	with	ADP
ecj-10810	115	73	higher	high	ADJ
ecj-10810	115	74	mortality,71,72	mortality,71,72	PROPN
ecj-10810	115	75	but	but	CCONJ
ecj-10810	115	76	this	this	DET
ecj-10810	115	77	evidence	evidence	NOUN
ecj-10810	115	78	is	be	AUX
ecj-10810	115	79	affected	affect	VERB
ecj-10810	115	80	by	by	ADP
ecj-10810	115	81	the	the	DET
ecj-10810	115	82	fact	fact	NOUN
ecj-10810	115	83	that	that	SCONJ
ecj-10810	115	84	it	it	PRON
ecj-10810	115	85	is	be	AUX
ecj-10810	115	86	generally	generally	ADV
ecj-10810	115	87	the	the	DET
ecj-10810	115	88	most	most	ADV
ecj-10810	115	89	severe	severe	ADJ
ecj-10810	115	90	patients	patient	NOUN
ecj-10810	115	91	who	who	PRON
ecj-10810	115	92	receive	receive	VERB
ecj-10810	115	93	the	the	DET
ecj-10810	115	94	most	most	ADV
ecj-10810	115	95	intense	intense	ADJ
ecj-10810	115	96	and	and	CCONJ
ecj-10810	115	97	prolonged	prolonged	ADJ
ecj-10810	115	98	drug	drug	NOUN
ecj-10810	115	99	treatment	treatment	NOUN
ecj-10810	115	100	.	.	PUNCT
ecj-10810	116	1	finally	finally	ADV
ecj-10810	116	2	,	,	PUNCT
ecj-10810	116	3	a	a	DET
ecj-10810	116	4	possible	possible	ADJ
ecj-10810	116	5	negative	negative	ADJ
ecj-10810	116	6	immunomodulatory	immunomodulatory	ADJ
ecj-10810	116	7	effect	effect	NOUN
ecj-10810	116	8	of	of	ADP
ecj-10810	116	9	noradrenaline	noradrenaline	NOUN
ecj-10810	116	10	has	have	AUX
ecj-10810	116	11	been	be	AUX
ecj-10810	116	12	discussed.73	discussed.73	ADJ
ecj-10810	116	13	clinical	clinical	ADJ
ecj-10810	116	14	documentation	documentation	NOUN
ecj-10810	116	15	for	for	ADP
ecj-10810	116	16	dobutamine	dobutamine	NOUN
ecj-10810	116	17	is	be	AUX
ecj-10810	116	18	also	also	ADV
ecj-10810	116	19	sparse	sparse	ADJ
ecj-10810	116	20	and	and	CCONJ
ecj-10810	116	21	inconclusive	inconclusive	ADJ
ecj-10810	116	22	although	although	SCONJ
ecj-10810	116	23	guidelines	guideline	NOUN
ecj-10810	116	24	continue	continue	VERB
ecj-10810	116	25	to	to	PART
ecj-10810	116	26	recommend	recommend	VERB
ecj-10810	116	27	it	it	PRON
ecj-10810	116	28	in	in	ADP
ecj-10810	116	29	patients	patient	NOUN
ecj-10810	116	30	with	with	ADP
ecj-10810	116	31	impaired	impaired	ADJ
ecj-10810	116	32	inotropism	inotropism	NOUN
ecj-10810	116	33	and	and	CCONJ
ecj-10810	116	34	poor	poor	ADJ
ecj-10810	116	35	response	response	NOUN
ecj-10810	116	36	to	to	ADP
ecj-10810	116	37	fluids	fluid	NOUN
ecj-10810	116	38	and	and	CCONJ
ecj-10810	116	39	noradrenaline	noradrenaline	NOUN
ecj-10810	116	40	.	.	PUNCT
ecj-10810	117	1	in	in	ADP
ecj-10810	117	2	the	the	DET
ecj-10810	117	3	large	large	ADJ
ecj-10810	117	4	egdt	egdt	ADJ
ecj-10810	117	5	studies	study	NOUN
ecj-10810	117	6	,	,	PUNCT
ecj-10810	117	7	dobutamine	dobutamine	NOUN
ecj-10810	117	8	was	be	AUX
ecj-10810	117	9	used	use	VERB
ecj-10810	117	10	in	in	ADP
ecj-10810	117	11	about	about	ADV
ecj-10810	117	12	1	1	NUM
ecj-10810	117	13	%	%	NOUN
ecj-10810	117	14	of	of	ADP
ecj-10810	117	15	patients	patient	NOUN
ecj-10810	117	16	in	in	ADP
ecj-10810	117	17	the	the	DET
ecj-10810	117	18	control	control	NOUN
ecj-10810	117	19	group	group	NOUN
ecj-10810	117	20	and	and	CCONJ
ecj-10810	117	21	10	10	NUM
ecj-10810	117	22	-	-	SYM
ecj-10810	117	23	15	15	NUM
ecj-10810	117	24	%	%	NOUN
ecj-10810	117	25	of	of	ADP
ecj-10810	117	26	patients	patient	NOUN
ecj-10810	117	27	in	in	ADP
ecj-10810	117	28	the	the	DET
ecj-10810	117	29	egdt	egdt	ADJ
ecj-10810	117	30	group	group	NOUN
ecj-10810	117	31	with	with	ADP
ecj-10810	117	32	no	no	DET
ecj-10810	117	33	difference	difference	NOUN
ecj-10810	117	34	in	in	ADP
ecj-10810	117	35	mortality	mortality	NOUN
ecj-10810	117	36	.	.	PUNCT
ecj-10810	118	1	moreover	moreover	ADV
ecj-10810	118	2	,	,	PUNCT
ecj-10810	118	3	several	several	ADJ
ecj-10810	118	4	studies	study	NOUN
ecj-10810	118	5	seem	seem	VERB
ecj-10810	118	6	to	to	PART
ecj-10810	118	7	document	document	VERB
ecj-10810	118	8	a	a	DET
ecj-10810	118	9	positive	positive	ADJ
ecj-10810	118	10	effect	effect	NOUN
ecj-10810	118	11	of	of	ADP
ecj-10810	118	12	b	b	NOUN
ecj-10810	118	13	-	-	PUNCT
ecj-10810	118	14	blockers	blocker	NOUN
ecj-10810	118	15	in	in	ADP
ecj-10810	118	16	patients	patient	NOUN
ecj-10810	118	17	with	with	ADP
ecj-10810	118	18	septic	septic	ADJ
ecj-10810	118	19	shock	shock	NOUN
ecj-10810	118	20	,	,	PUNCT
ecj-10810	118	21	making	make	VERB
ecj-10810	118	22	it	it	PRON
ecj-10810	118	23	even	even	ADV
ecj-10810	118	24	more	more	ADV
ecj-10810	118	25	problematic	problematic	ADJ
ecj-10810	118	26	to	to	PART
ecj-10810	118	27	employ	employ	VERB
ecj-10810	118	28	a	a	DET
ecj-10810	118	29	drug	drug	NOUN
ecj-10810	118	30	with	with	ADP
ecj-10810	118	31	a	a	DET
ecj-10810	118	32	strong	strong	ADJ
ecj-10810	118	33	b	b	NOUN
ecj-10810	118	34	-	-	PUNCT
ecj-10810	118	35	agonist	agonist	NOUN
ecj-10810	118	36	activity.74	activity.74	NOUN
ecj-10810	118	37	sepsis	sepsis	NOUN
ecj-10810	118	38	at	at	ADP
ecj-10810	118	39	the	the	DET
ecj-10810	118	40	end	end	NOUN
ecj-10810	118	41	of	of	ADP
ecj-10810	118	42	life	life	NOUN
ecj-10810	118	43	although	although	SCONJ
ecj-10810	118	44	sepsis	sepsis	NOUN
ecj-10810	118	45	and	and	CCONJ
ecj-10810	118	46	septic	septic	ADJ
ecj-10810	118	47	shock	shock	NOUN
ecj-10810	118	48	can	can	AUX
ecj-10810	118	49	occur	occur	VERB
ecj-10810	118	50	at	at	ADP
ecj-10810	118	51	any	any	DET
ecj-10810	118	52	age	age	NOUN
ecj-10810	118	53	,	,	PUNCT
ecj-10810	118	54	almost	almost	ADV
ecj-10810	118	55	80	80	NUM
ecj-10810	118	56	%	%	NOUN
ecj-10810	118	57	of	of	ADP
ecj-10810	118	58	deaths	death	NOUN
ecj-10810	118	59	in	in	ADP
ecj-10810	118	60	british	british	ADJ
ecj-10810	118	61	hospitals	hospital	NOUN
ecj-10810	118	62	concern	concern	NOUN
ecj-10810	118	63	patients	patient	NOUN
ecj-10810	118	64	>	>	PUNCT
ecj-10810	118	65	75	75	NUM
ecj-10810	118	66	years	year	NOUN
ecj-10810	118	67	of	of	ADP
ecj-10810	118	68	age	age	NOUN
ecj-10810	118	69	.	.	PUNCT
ecj-10810	119	1	the	the	DET
ecj-10810	119	2	high	high	ADJ
ecj-10810	119	3	incidence	incidence	NOUN
ecj-10810	119	4	of	of	ADP
ecj-10810	119	5	frailty	frailty	NOUN
ecj-10810	119	6	and	and	CCONJ
ecj-10810	119	7	severe	severe	ADJ
ecj-10810	119	8	comorbidities	comorbiditie	NOUN
ecj-10810	119	9	makes	make	VERB
ecj-10810	119	10	most	most	ADJ
ecj-10810	119	11	sepsis	sepsis	NOUN
ecj-10810	119	12	-	-	PUNCT
ecj-10810	119	13	related	relate	VERB
ecj-10810	119	14	deaths	death	NOUN
ecj-10810	119	15	not	not	PART
ecj-10810	119	16	directly	directly	ADV
ecj-10810	119	17	attributable	attributable	ADJ
ecj-10810	119	18	to	to	ADP
ecj-10810	119	19	sepsis	sepsis	NOUN
ecj-10810	119	20	,	,	PUNCT
ecj-10810	119	21	nor	nor	CCONJ
ecj-10810	119	22	preventable	preventable	ADJ
ecj-10810	119	23	through	through	ADP
ecj-10810	119	24	timely	timely	ADJ
ecj-10810	119	25	therapeutic	therapeutic	ADJ
ecj-10810	119	26	interventions	intervention	NOUN
ecj-10810	119	27	.	.	PUNCT
ecj-10810	120	1	in	in	ADP
ecj-10810	120	2	a	a	DET
ecj-10810	120	3	point	point	NOUN
ecj-10810	120	4	prevalence	prevalence	NOUN
ecj-10810	120	5	study	study	NOUN
ecj-10810	120	6	in	in	ADP
ecj-10810	120	7	british	british	ADJ
ecj-10810	120	8	hospitals	hospital	NOUN
ecj-10810	120	9	including	include	VERB
ecj-10810	120	10	521	521	NUM
ecj-10810	120	11	patients	patient	NOUN
ecj-10810	120	12	with	with	ADP
ecj-10810	120	13	sepsis	sepsis	NOUN
ecj-10810	120	14	and	and	CCONJ
ecj-10810	120	15	136	136	NUM
ecj-10810	120	16	deaths	death	NOUN
ecj-10810	120	17	,	,	PUNCT
ecj-10810	120	18	only	only	ADV
ecj-10810	120	19	40	40	NUM
ecj-10810	120	20	deaths	death	NOUN
ecj-10810	120	21	were	be	AUX
ecj-10810	120	22	directly	directly	ADV
ecj-10810	120	23	or	or	CCONJ
ecj-10810	120	24	possibly	possibly	ADV
ecj-10810	120	25	attributable	attributable	ADJ
ecj-10810	120	26	to	to	ADP
ecj-10810	120	27	sepsis.75	sepsis.75	PROPN
ecj-10810	120	28	of	of	ADP
ecj-10810	120	29	these	these	PRON
ecj-10810	120	30	,	,	PUNCT
ecj-10810	120	31	77.5	77.5	NUM
ecj-10810	120	32	%	%	NOUN
ecj-10810	120	33	were	be	AUX
ecj-10810	120	34	in	in	ADP
ecj-10810	120	35	patients	patient	NOUN
ecj-10810	120	36	who	who	PRON
ecj-10810	120	37	had	have	VERB
ecj-10810	120	38	substantial	substantial	ADJ
ecj-10810	120	39	frailty	frailty	NOUN
ecj-10810	120	40	,	,	PUNCT
ecj-10810	120	41	and	and	CCONJ
ecj-10810	120	42	70	70	NUM
ecj-10810	120	43	%	%	NOUN
ecj-10810	120	44	were	be	AUX
ecj-10810	120	45	in	in	ADP
ecj-10810	120	46	patients	patient	NOUN
ecj-10810	120	47	who	who	PRON
ecj-10810	120	48	were	be	AUX
ecj-10810	120	49	considered	consider	VERB
ecj-10810	120	50	not	not	PART
ecj-10810	120	51	to	to	PART
ecj-10810	120	52	resuscitate	resuscitate	VERB
ecj-10810	120	53	in	in	ADP
ecj-10810	120	54	the	the	DET
ecj-10810	120	55	event	event	NOUN
ecj-10810	120	56	of	of	ADP
ecj-10810	120	57	cardiac	cardiac	ADJ
ecj-10810	120	58	arrest	arrest	NOUN
ecj-10810	120	59	.	.	PUNCT
ecj-10810	121	1	a	a	DET
ecj-10810	121	2	us	us	PROPN
ecj-10810	121	3	study	study	NOUN
ecj-10810	121	4	estimated	estimate	VERB
ecj-10810	121	5	that	that	SCONJ
ecj-10810	121	6	only	only	ADV
ecj-10810	121	7	12	12	NUM
ecj-10810	121	8	%	%	NOUN
ecj-10810	121	9	of	of	ADP
ecj-10810	121	10	sepsis	sepsis	NOUN
ecj-10810	121	11	deaths	death	NOUN
ecj-10810	121	12	were	be	AUX
ecj-10810	121	13	possibly	possibly	ADV
ecj-10810	121	14	-	-	PUNCT
ecj-10810	121	15	to	to	AUX
ecj-10810	121	16	-	-	PUNCT
ecj-10810	121	17	definitely	definitely	ADV
ecj-10810	121	18	preventable.76	preventable.76	NOUN
ecj-10810	121	19	although	although	SCONJ
ecj-10810	121	20	it	it	PRON
ecj-10810	121	21	is	be	AUX
ecj-10810	121	22	difficult	difficult	ADJ
ecj-10810	121	23	to	to	PART
ecj-10810	121	24	retrieve	retrieve	VERB
ecj-10810	121	25	data	datum	NOUN
ecj-10810	121	26	on	on	ADP
ecj-10810	121	27	the	the	DET
ecj-10810	121	28	percentage	percentage	NOUN
ecj-10810	121	29	of	of	ADP
ecj-10810	121	30	patients	patient	NOUN
ecj-10810	121	31	with	with	ADP
ecj-10810	121	32	septic	septic	ADJ
ecj-10810	121	33	shock	shock	NOUN
ecj-10810	121	34	who	who	PRON
ecj-10810	121	35	are	be	AUX
ecj-10810	121	36	directly	directly	ADV
ecj-10810	121	37	admitted	admit	VERB
ecj-10810	121	38	from	from	ADP
ecj-10810	121	39	the	the	DET
ecj-10810	121	40	ed	ed	NOUN
ecj-10810	121	41	to	to	ADP
ecj-10810	121	42	the	the	DET
ecj-10810	121	43	icu	icu	NOUN
ecj-10810	121	44	,	,	PUNCT
ecj-10810	121	45	it	it	PRON
ecj-10810	121	46	is	be	AUX
ecj-10810	121	47	a	a	DET
ecj-10810	121	48	common	common	ADJ
ecj-10810	121	49	experience	experience	NOUN
ecj-10810	121	50	that	that	SCONJ
ecj-10810	121	51	the	the	DET
ecj-10810	121	52	very	very	ADV
ecj-10810	121	53	elderly	elderly	ADJ
ecj-10810	121	54	and	and	CCONJ
ecj-10810	121	55	frailest	frail	ADJ
ecj-10810	121	56	patients	patient	NOUN
ecj-10810	121	57	are	be	AUX
ecj-10810	121	58	often	often	ADV
ecj-10810	121	59	admitted	admit	VERB
ecj-10810	121	60	to	to	ADP
ecj-10810	121	61	general	general	ADJ
ecj-10810	121	62	wards	ward	NOUN
ecj-10810	121	63	.	.	PUNCT
ecj-10810	122	1	this	this	PRON
ecj-10810	122	2	limits	limit	VERB
ecj-10810	122	3	the	the	DET
ecj-10810	122	4	monitoring	monitoring	NOUN
ecj-10810	122	5	capability	capability	NOUN
ecj-10810	122	6	as	as	ADV
ecj-10810	122	7	well	well	ADV
ecj-10810	122	8	as	as	ADP
ecj-10810	122	9	the	the	DET
ecj-10810	122	10	aggressiveness	aggressiveness	NOUN
ecj-10810	122	11	of	of	ADP
ecj-10810	122	12	therapy	therapy	NOUN
ecj-10810	122	13	.	.	PUNCT
ecj-10810	123	1	a	a	DET
ecj-10810	123	2	practical	practical	ADJ
ecj-10810	123	3	approach	approach	NOUN
ecj-10810	123	4	to	to	ADP
ecj-10810	123	5	the	the	DET
ecj-10810	123	6	early	early	ADJ
ecj-10810	123	7	therapy	therapy	NOUN
ecj-10810	123	8	of	of	ADP
ecj-10810	123	9	septic	septic	ADJ
ecj-10810	123	10	shock	shock	NOUN
ecj-10810	123	11	in	in	ADP
ecj-10810	123	12	the	the	DET
ecj-10810	123	13	ed	ed	NOUN
ecj-10810	123	14	as	as	SCONJ
ecj-10810	123	15	we	we	PRON
ecj-10810	123	16	have	have	AUX
ecj-10810	123	17	seen	see	VERB
ecj-10810	123	18	,	,	PUNCT
ecj-10810	123	19	a	a	DET
ecj-10810	123	20	substantial	substantial	ADJ
ecj-10810	123	21	number	number	NOUN
ecj-10810	123	22	of	of	ADP
ecj-10810	123	23	patients	patient	NOUN
ecj-10810	123	24	with	with	ADP
ecj-10810	123	25	septic	septic	ADJ
ecj-10810	123	26	shock	shock	NOUN
ecj-10810	123	27	are	be	AUX
ecj-10810	123	28	not	not	PART
ecj-10810	123	29	admitted	admit	VERB
ecj-10810	123	30	to	to	ADP
ecj-10810	123	31	the	the	DET
ecj-10810	123	32	icu	icu	PROPN
ecj-10810	123	33	because	because	SCONJ
ecj-10810	123	34	of	of	ADP
ecj-10810	123	35	frailty	frailty	NOUN
ecj-10810	123	36	and	and	CCONJ
ecj-10810	123	37	severe	severe	ADJ
ecj-10810	123	38	comorbidities	comorbiditie	NOUN
ecj-10810	123	39	.	.	PUNCT
ecj-10810	124	1	it	it	PRON
ecj-10810	124	2	is	be	AUX
ecj-10810	124	3	thus	thus	ADV
ecj-10810	124	4	of	of	ADP
ecj-10810	124	5	the	the	DET
ecj-10810	124	6	utmost	utmost	ADJ
ecj-10810	124	7	importance	importance	NOUN
ecj-10810	124	8	that	that	SCONJ
ecj-10810	124	9	the	the	DET
ecj-10810	124	10	chance	chance	NOUN
ecj-10810	124	11	of	of	ADP
ecj-10810	124	12	a	a	DET
ecj-10810	124	13	patient	patient	NOUN
ecj-10810	124	14	being	be	AUX
ecj-10810	124	15	admitted	admit	VERB
ecj-10810	124	16	to	to	ADP
ecj-10810	124	17	the	the	DET
ecj-10810	124	18	icu	icu	PROPN
ecj-10810	124	19	is	be	AUX
ecj-10810	124	20	evaluated	evaluate	VERB
ecj-10810	124	21	early	early	ADV
ecj-10810	124	22	.	.	PUNCT
ecj-10810	125	1	when	when	SCONJ
ecj-10810	125	2	icu	icu	PROPN
ecj-10810	125	3	seems	seem	VERB
ecj-10810	125	4	a	a	DET
ecj-10810	125	5	concrete	concrete	ADJ
ecj-10810	125	6	possibility	possibility	NOUN
ecj-10810	125	7	,	,	PUNCT
ecj-10810	125	8	the	the	DET
ecj-10810	125	9	intensivists	intensivist	NOUN
ecj-10810	125	10	should	should	AUX
ecj-10810	125	11	be	be	AUX
ecj-10810	125	12	informed	inform	VERB
ecj-10810	125	13	and	and	CCONJ
ecj-10810	125	14	involved	involve	VERB
ecj-10810	125	15	from	from	ADP
ecj-10810	125	16	the	the	DET
ecj-10810	125	17	very	very	ADV
ecj-10810	125	18	early	early	ADJ
ecj-10810	125	19	stages	stage	NOUN
ecj-10810	125	20	of	of	ADP
ecj-10810	125	21	therapy	therapy	NOUN
ecj-10810	125	22	.	.	PUNCT
ecj-10810	126	1	when	when	SCONJ
ecj-10810	126	2	icu	icu	PROPN
ecj-10810	126	3	admission	admission	NOUN
ecj-10810	126	4	is	be	AUX
ecj-10810	126	5	not	not	PART
ecj-10810	126	6	envisaged	envisage	VERB
ecj-10810	126	7	,	,	PUNCT
ecj-10810	126	8	the	the	DET
ecj-10810	126	9	clinical	clinical	ADJ
ecj-10810	126	10	approach	approach	NOUN
ecj-10810	126	11	must	must	AUX
ecj-10810	126	12	be	be	AUX
ecj-10810	126	13	carried	carry	VERB
ecj-10810	126	14	out	out	ADP
ecj-10810	126	15	within	within	ADP
ecj-10810	126	16	the	the	DET
ecj-10810	126	17	frame	frame	NOUN
ecj-10810	126	18	of	of	ADP
ecj-10810	126	19	the	the	DET
ecj-10810	126	20	available	available	ADJ
ecj-10810	126	21	monitoring	monitoring	NOUN
ecj-10810	126	22	equipment	equipment	NOUN
ecj-10810	126	23	and	and	CCONJ
ecj-10810	126	24	physicians	physician	NOUN
ecj-10810	126	25	’	'	PUNCT
ecj-10810	126	26	expertise	expertise	NOUN
ecj-10810	126	27	.	.	PUNCT
ecj-10810	127	1	basic	basic	ADJ
ecj-10810	127	2	competence	competence	NOUN
ecj-10810	127	3	in	in	ADP
ecj-10810	127	4	sonography	sonography	NOUN
ecj-10810	127	5	is	be	AUX
ecj-10810	127	6	the	the	DET
ecj-10810	127	7	minimum	minimum	ADJ
ecj-10810	127	8	standard	standard	NOUN
ecj-10810	127	9	acceptable	acceptable	ADJ
ecj-10810	127	10	for	for	ADP
ecj-10810	127	11	ed	ed	PROPN
ecj-10810	127	12	physicians	physician	NOUN
ecj-10810	127	13	called	call	VERB
ecj-10810	127	14	to	to	PART
ecj-10810	127	15	treat	treat	VERB
ecj-10810	127	16	patients	patient	NOUN
ecj-10810	127	17	in	in	ADP
ecj-10810	127	18	septic	septic	ADJ
ecj-10810	127	19	shock	shock	NOUN
ecj-10810	127	20	.	.	PUNCT
ecj-10810	128	1	competence	competence	NOUN
ecj-10810	128	2	in	in	ADP
ecj-10810	128	3	echocardiography	echocardiography	NOUN
ecj-10810	128	4	to	to	PART
ecj-10810	128	5	estimate	estimate	VERB
ecj-10810	128	6	sv	sv	PROPN
ecj-10810	128	7	would	would	AUX
ecj-10810	128	8	be	be	AUX
ecj-10810	128	9	a	a	DET
ecj-10810	128	10	welcome	welcome	ADJ
ecj-10810	128	11	addition	addition	NOUN
ecj-10810	128	12	.	.	PUNCT
ecj-10810	129	1	both	both	CCONJ
ecj-10810	129	2	the	the	DET
ecj-10810	129	3	physiology	physiology	NOUN
ecj-10810	129	4	of	of	ADP
ecj-10810	129	5	macrocirculation	macrocirculation	NOUN
ecj-10810	129	6	and	and	CCONJ
ecj-10810	129	7	microcirculation	microcirculation	NOUN
ecj-10810	129	8	and	and	CCONJ
ecj-10810	129	9	the	the	DET
ecj-10810	129	10	results	result	NOUN
ecj-10810	129	11	of	of	ADP
ecj-10810	129	12	clinical	clinical	ADJ
ecj-10810	129	13	trials	trial	NOUN
ecj-10810	129	14	confirm	confirm	VERB
ecj-10810	129	15	that	that	SCONJ
ecj-10810	129	16	fluids	fluid	NOUN
ecj-10810	129	17	and	and	CCONJ
ecj-10810	129	18	vasopressors	vasopressor	NOUN
ecj-10810	129	19	are	be	AUX
ecj-10810	129	20	indicated	indicate	VERB
ecj-10810	129	21	and	and	CCONJ
ecj-10810	129	22	effective	effective	ADJ
ecj-10810	129	23	in	in	ADP
ecj-10810	129	24	the	the	DET
ecj-10810	129	25	treatment	treatment	NOUN
ecj-10810	129	26	of	of	ADP
ecj-10810	129	27	septic	septic	ADJ
ecj-10810	129	28	shock	shock	NOUN
ecj-10810	129	29	.	.	PUNCT
ecj-10810	130	1	as	as	SCONJ
ecj-10810	130	2	we	we	PRON
ecj-10810	130	3	have	have	AUX
ecj-10810	130	4	seen	see	VERB
ecj-10810	130	5	,	,	PUNCT
ecj-10810	130	6	the	the	DET
ecj-10810	130	7	most	most	ADV
ecj-10810	130	8	recent	recent	ADJ
ecj-10810	130	9	data	datum	NOUN
ecj-10810	130	10	tend	tend	VERB
ecj-10810	130	11	to	to	PART
ecj-10810	130	12	favour	favour	VERB
ecj-10810	130	13	an	an	DET
ecj-10810	130	14	earlier	early	ADJ
ecj-10810	130	15	initiation	initiation	NOUN
ecj-10810	130	16	of	of	ADP
ecj-10810	130	17	vasopressors	vasopressor	NOUN
ecj-10810	130	18	than	than	SCONJ
ecj-10810	130	19	previously	previously	ADV
ecj-10810	130	20	advised	advise	VERB
ecj-10810	130	21	.	.	PUNCT
ecj-10810	131	1	in	in	ADP
ecj-10810	131	2	evaluating	evaluate	VERB
ecj-10810	131	3	the	the	DET
ecj-10810	131	4	approach	approach	NOUN
ecj-10810	131	5	to	to	ADP
ecj-10810	131	6	fluid	fluid	ADJ
ecj-10810	131	7	administration	administration	NOUN
ecj-10810	131	8	,	,	PUNCT
ecj-10810	131	9	one	one	PRON
ecj-10810	131	10	must	must	AUX
ecj-10810	131	11	consider	consider	VERB
ecj-10810	131	12	that	that	SCONJ
ecj-10810	131	13	ed	ed	PROPN
ecj-10810	131	14	physicians	physician	NOUN
ecj-10810	131	15	face	face	VERB
ecj-10810	131	16	septic	septic	ADJ
ecj-10810	131	17	patients	patient	NOUN
ecj-10810	131	18	with	with	ADP
ecj-10810	131	19	hypotension	hypotension	NOUN
ecj-10810	131	20	that	that	PRON
ecj-10810	131	21	are	be	AUX
ecj-10810	131	22	not	not	PART
ecj-10810	131	23	always	always	ADV
ecj-10810	131	24	similar	similar	ADJ
ecj-10810	131	25	to	to	ADP
ecj-10810	131	26	those	those	PRON
ecj-10810	131	27	treated	treat	VERB
ecj-10810	131	28	in	in	ADP
ecj-10810	131	29	clinical	clinical	ADJ
ecj-10810	131	30	trials	trial	NOUN
ecj-10810	131	31	(	(	PUNCT
ecj-10810	131	32	that	that	SCONJ
ecj-10810	131	33	by	by	ADP
ecj-10810	131	34	definition	definition	NOUN
ecj-10810	131	35	are	be	AUX
ecj-10810	131	36	enrolled	enrol	VERB
ecj-10810	131	37	only	only	ADV
ecj-10810	131	38	after	after	ADP
ecj-10810	131	39	a	a	DET
ecj-10810	131	40	first	first	ADJ
ecj-10810	131	41	ineffective	ineffective	ADJ
ecj-10810	131	42	bolus	bolus	NOUN
ecj-10810	131	43	of	of	ADP
ecj-10810	131	44	crystalloids	crystalloid	NOUN
ecj-10810	131	45	)	)	PUNCT
ecj-10810	131	46	.	.	PUNCT
ecj-10810	132	1	as	as	ADP
ecj-10810	132	2	a	a	DET
ecj-10810	132	3	consequence	consequence	NOUN
ecj-10810	132	4	,	,	PUNCT
ecj-10810	132	5	although	although	SCONJ
ecj-10810	132	6	the	the	DET
ecj-10810	132	7	administration	administration	NOUN
ecj-10810	132	8	of	of	ADP
ecj-10810	132	9	30	30	NUM
ecj-10810	132	10	ml	ml	NOUN
ecj-10810	132	11	/	/	SYM
ecj-10810	132	12	kg	kg	NOUN
ecj-10810	132	13	of	of	ADP
ecj-10810	132	14	crystalloids	crystalloid	NOUN
ecj-10810	132	15	in	in	ADP
ecj-10810	132	16	the	the	DET
ecj-10810	132	17	first	first	ADJ
ecj-10810	132	18	3	3	NUM
ecj-10810	132	19	hours	hour	NOUN
ecj-10810	132	20	is	be	AUX
ecj-10810	132	21	still	still	ADV
ecj-10810	132	22	recommended	recommend	VERB
ecj-10810	132	23	by	by	ADP
ecj-10810	132	24	the	the	DET
ecj-10810	132	25	surviving	survive	VERB
ecj-10810	132	26	sepsis	sepsis	NOUN
ecj-10810	132	27	campaign	campaign	NOUN
ecj-10810	132	28	guidelines	guideline	NOUN
ecj-10810	132	29	and	and	CCONJ
ecj-10810	132	30	sounds	sound	VERB
ecj-10810	132	31	reasonable	reasonable	ADJ
ecj-10810	132	32	as	as	ADP
ecj-10810	132	33	a	a	DET
ecj-10810	132	34	first	first	ADJ
ecj-10810	132	35	approach	approach	NOUN
ecj-10810	132	36	,	,	PUNCT
ecj-10810	132	37	it	it	PRON
ecj-10810	132	38	might	might	AUX
ecj-10810	132	39	be	be	AUX
ecj-10810	132	40	appropriate	appropriate	ADJ
ecj-10810	132	41	to	to	PART
ecj-10810	132	42	evaluate	evaluate	VERB
ecj-10810	132	43	the	the	DET
ecj-10810	132	44	efficacy	efficacy	NOUN
ecj-10810	132	45	of	of	ADP
ecj-10810	132	46	volume	volume	NOUN
ecj-10810	132	47	expansion	expansion	NOUN
ecj-10810	132	48	as	as	ADV
ecj-10810	132	49	early	early	ADV
ecj-10810	132	50	as	as	ADP
ecj-10810	132	51	after	after	ADP
ecj-10810	132	52	the	the	DET
ecj-10810	132	53	first	first	ADJ
ecj-10810	132	54	1000	1000	NUM
ecj-10810	132	55	ml	ml	NOUN
ecj-10810	132	56	of	of	ADP
ecj-10810	132	57	crystalloids	crystalloid	NOUN
ecj-10810	132	58	.	.	PUNCT
ecj-10810	133	1	particular	particular	ADJ
ecj-10810	133	2	attention	attention	NOUN
ecj-10810	133	3	should	should	AUX
ecj-10810	133	4	be	be	AUX
ecj-10810	133	5	paid	pay	VERB
ecj-10810	133	6	to	to	ADP
ecj-10810	133	7	patients	patient	NOUN
ecj-10810	133	8	with	with	ADP
ecj-10810	133	9	left	left	ADJ
ecj-10810	133	10	ventricular	ventricular	ADJ
ecj-10810	133	11	failure	failure	NOUN
ecj-10810	133	12	,	,	PUNCT
ecj-10810	133	13	in	in	ADP
ecj-10810	133	14	whom	whom	PRON
ecj-10810	133	15	volemic	volemic	ADJ
ecj-10810	133	16	expansion	expansion	NOUN
ecj-10810	133	17	has	have	VERB
ecj-10810	133	18	little	little	ADJ
ecj-10810	133	19	effect	effect	NOUN
ecj-10810	133	20	on	on	ADP
ecj-10810	133	21	preload	preload	NOUN
ecj-10810	133	22	and	and	CCONJ
ecj-10810	133	23	may	may	AUX
ecj-10810	133	24	cause	cause	VERB
ecj-10810	133	25	pulmonary	pulmonary	ADJ
ecj-10810	133	26	edema	edema	NOUN
ecj-10810	133	27	.	.	PUNCT
ecj-10810	134	1	a	a	DET
ecj-10810	134	2	respiratory	respiratory	ADJ
ecj-10810	134	3	collapse	collapse	NOUN
ecj-10810	134	4	>	>	PUNCT
ecj-10810	134	5	50	50	NUM
ecj-10810	134	6	%	%	NOUN
ecj-10810	134	7	of	of	ADP
ecj-10810	134	8	the	the	DET
ecj-10810	134	9	inferior	inferior	ADJ
ecj-10810	134	10	vena	vena	NOUN
ecj-10810	134	11	cava	cava	NOUN
ecj-10810	134	12	is	be	AUX
ecj-10810	134	13	an	an	DET
ecj-10810	134	14	acceptable	acceptable	ADJ
ecj-10810	134	15	sign	sign	NOUN
ecj-10810	134	16	that	that	SCONJ
ecj-10810	134	17	the	the	DET
ecj-10810	134	18	patient	patient	NOUN
ecj-10810	134	19	will	will	AUX
ecj-10810	134	20	tolerate	tolerate	VERB
ecj-10810	134	21	a	a	DET
ecj-10810	134	22	further	further	ADJ
ecj-10810	134	23	fluid	fluid	ADJ
ecj-10810	134	24	bolus	bolus	NOUN
ecj-10810	134	25	,	,	PUNCT
ecj-10810	134	26	though	though	SCONJ
ecj-10810	134	27	not	not	PART
ecj-10810	134	28	the	the	DET
ecj-10810	134	29	best	good	ADJ
ecj-10810	134	30	way	way	NOUN
ecj-10810	134	31	to	to	PART
ecj-10810	134	32	evaluate	evaluate	VERB
ecj-10810	134	33	fluid	fluid	ADJ
ecj-10810	134	34	responsiveness	responsiveness	NOUN
ecj-10810	134	35	.	.	PUNCT
ecj-10810	135	1	repeated	repeat	VERB
ecj-10810	135	2	pulmonary	pulmonary	ADJ
ecj-10810	135	3	ultrasound	ultrasound	NOUN
ecj-10810	135	4	may	may	AUX
ecj-10810	135	5	help	help	VERB
ecj-10810	135	6	identify	identify	VERB
ecj-10810	135	7	the	the	DET
ecj-10810	135	8	early	early	ADJ
ecj-10810	135	9	signs	sign	NOUN
ecj-10810	135	10	of	of	ADP
ecj-10810	135	11	interstitial	interstitial	ADJ
ecj-10810	135	12	edema	edema	NOUN
ecj-10810	135	13	.	.	PUNCT
ecj-10810	136	1	the	the	DET
ecj-10810	136	2	lack	lack	NOUN
ecj-10810	136	3	of	of	ADP
ecj-10810	136	4	a	a	DET
ecj-10810	136	5	consistent	consistent	ADJ
ecj-10810	136	6	correlation	correlation	NOUN
ecj-10810	136	7	between	between	ADP
ecj-10810	136	8	improved	improve	VERB
ecj-10810	136	9	hemodynamic	hemodynamic	ADJ
ecj-10810	136	10	values	value	NOUN
ecj-10810	136	11	and	and	CCONJ
ecj-10810	136	12	tissue	tissue	NOUN
ecj-10810	136	13	oxygenation	oxygenation	NOUN
ecj-10810	136	14	status	status	NOUN
ecj-10810	136	15	suggests	suggest	VERB
ecj-10810	136	16	that	that	SCONJ
ecj-10810	136	17	macrocirculation	macrocirculation	NOUN
ecj-10810	136	18	-	-	PUNCT
ecj-10810	136	19	related	relate	VERB
ecj-10810	136	20	parameters	parameter	NOUN
ecj-10810	136	21	(	(	PUNCT
ecj-10810	136	22	pa	pa	PROPN
ecj-10810	136	23	,	,	PUNCT
ecj-10810	136	24	cvp	cvp	PROPN
ecj-10810	136	25	,	,	PUNCT
ecj-10810	136	26	sv	sv	X
ecj-10810	136	27	when	when	SCONJ
ecj-10810	136	28	available	available	ADJ
ecj-10810	136	29	)	)	PUNCT
ecj-10810	136	30	be	be	AUX
ecj-10810	136	31	always	always	ADV
ecj-10810	136	32	evaluated	evaluate	VERB
ecj-10810	136	33	in	in	ADP
ecj-10810	136	34	the	the	DET
ecj-10810	136	35	light	light	NOUN
ecj-10810	136	36	of	of	ADP
ecj-10810	136	37	tissue	tissue	NOUN
ecj-10810	136	38	perfusion	perfusion	NOUN
ecj-10810	136	39	sensitive	sensitive	ADJ
ecj-10810	136	40	parameters	parameter	NOUN
ecj-10810	136	41	(	(	PUNCT
ecj-10810	136	42	level	level	NOUN
ecj-10810	136	43	of	of	ADP
ecj-10810	136	44	consciousness	consciousness	NOUN
ecj-10810	136	45	,	,	PUNCT
ecj-10810	136	46	urinary	urinary	ADJ
ecj-10810	136	47	output	output	NOUN
ecj-10810	136	48	,	,	PUNCT
ecj-10810	136	49	crt	crt	ADJ
ecj-10810	136	50	,	,	PUNCT
ecj-10810	136	51	lactates	lactate	NOUN
ecj-10810	136	52	,	,	PUNCT
ecj-10810	136	53	svco2	svco2	NOUN
ecj-10810	136	54	)	)	PUNCT
ecj-10810	136	55	.	.	PUNCT
ecj-10810	137	1	crt	crt	PROPN
ecj-10810	137	2	is	be	AUX
ecj-10810	137	3	an	an	DET
ecj-10810	137	4	old	old	ADJ
ecj-10810	137	5	,	,	PUNCT
ecj-10810	137	6	but	but	CCONJ
ecj-10810	137	7	recently	recently	ADV
ecj-10810	137	8	revaluated	revaluate	VERB
ecj-10810	137	9	assessment	assessment	NOUN
ecj-10810	137	10	that	that	PRON
ecj-10810	137	11	is	be	AUX
ecj-10810	137	12	easy	easy	ADJ
ecj-10810	137	13	to	to	PART
ecj-10810	137	14	perform	perform	VERB
ecj-10810	137	15	,	,	PUNCT
ecj-10810	137	16	can	can	AUX
ecj-10810	137	17	be	be	AUX
ecj-10810	137	18	repeated	repeat	VERB
ecj-10810	137	19	frequently	frequently	ADV
ecj-10810	137	20	,	,	PUNCT
ecj-10810	137	21	and	and	CCONJ
ecj-10810	137	22	might	might	AUX
ecj-10810	137	23	be	be	AUX
ecj-10810	137	24	particularly	particularly	ADV
ecj-10810	137	25	appropriate	appropriate	ADJ
ecj-10810	137	26	for	for	ADP
ecj-10810	137	27	the	the	DET
ecj-10810	137	28	ed	ed	NOUN
ecj-10810	137	29	setting	setting	NOUN
ecj-10810	137	30	.	.	PUNCT
ecj-10810	138	1	after	after	ADP
ecj-10810	138	2	the	the	DET
ecj-10810	138	3	first	first	ADJ
ecj-10810	138	4	1000	1000	NUM
ecj-10810	138	5	ml	ml	NOUN
ecj-10810	138	6	,	,	PUNCT
ecj-10810	138	7	crystalloids	crystalloid	NOUN
ecj-10810	138	8	should	should	AUX
ecj-10810	138	9	be	be	AUX
ecj-10810	138	10	preferentially	preferentially	ADV
ecj-10810	138	11	administered	administer	VERB
ecj-10810	138	12	in	in	ADP
ecj-10810	138	13	boluses	bolus	NOUN
ecj-10810	138	14	of	of	ADP
ecj-10810	138	15	250	250	NUM
ecj-10810	138	16	-	-	SYM
ecj-10810	138	17	500	500	NUM
ecj-10810	138	18	ml	ml	NOUN
ecj-10810	138	19	followed	follow	VERB
ecj-10810	138	20	by	by	ADP
ecj-10810	138	21	the	the	DET
ecj-10810	138	22	revaluation	revaluation	NOUN
ecj-10810	138	23	of	of	ADP
ecj-10810	138	24	the	the	DET
ecj-10810	138	25	patient	patient	NOUN
ecj-10810	138	26	’s	’s	PART
ecj-10810	138	27	vital	vital	ADJ
ecj-10810	138	28	parameters	parameter	NOUN
ecj-10810	138	29	and	and	CCONJ
ecj-10810	138	30	one	one	NUM
ecj-10810	138	31	or	or	CCONJ
ecj-10810	138	32	more	more	ADJ
ecj-10810	138	33	among	among	ADP
ecj-10810	138	34	ivc	ivc	NOUN
ecj-10810	138	35	and	and	CCONJ
ecj-10810	138	36	pulmonary	pulmonary	ADJ
ecj-10810	138	37	sonography	sonography	NOUN
ecj-10810	138	38	,	,	PUNCT
ecj-10810	138	39	sv	sv	PROPN
ecj-10810	138	40	,	,	PUNCT
ecj-10810	138	41	crt	crt	PROPN
ecj-10810	138	42	.	.	PUNCT
ecj-10810	139	1	as	as	ADP
ecj-10810	139	2	a	a	DET
ecj-10810	139	3	rough	rough	ADJ
ecj-10810	139	4	guide	guide	NOUN
ecj-10810	139	5	,	,	PUNCT
ecj-10810	139	6	it	it	PRON
ecj-10810	139	7	could	could	AUX
ecj-10810	139	8	be	be	AUX
ecj-10810	139	9	kept	keep	VERB
ecj-10810	139	10	in	in	ADP
ecj-10810	139	11	mind	mind	NOUN
ecj-10810	139	12	that	that	SCONJ
ecj-10810	139	13	patients	patient	NOUN
ecj-10810	139	14	enrolled	enrol	VERB
ecj-10810	139	15	in	in	ADP
ecj-10810	139	16	the	the	DET
ecj-10810	139	17	major	major	ADJ
ecj-10810	139	18	clinical	clinical	ADJ
ecj-10810	139	19	studies	study	NOUN
ecj-10810	139	20	on	on	ADP
ecj-10810	139	21	septic	septic	ADJ
ecj-10810	139	22	shock	shock	NOUN
ecj-10810	139	23	received	receive	VERB
ecj-10810	139	24	an	an	DET
ecj-10810	139	25	average	average	NOUN
ecj-10810	139	26	of	of	ADP
ecj-10810	139	27	4	4	NUM
ecj-10810	139	28	l	l	NOUN
ecj-10810	139	29	of	of	ADP
ecj-10810	139	30	crystalloids	crystalloid	NOUN
ecj-10810	139	31	in	in	ADP
ecj-10810	139	32	the	the	DET
ecj-10810	139	33	first	first	ADJ
ecj-10810	139	34	6	6	NUM
ecj-10810	139	35	hours	hour	NOUN
ecj-10810	139	36	,	,	PUNCT
ecj-10810	139	37	with	with	ADP
ecj-10810	139	38	a	a	DET
ecj-10810	139	39	rapid	rapid	ADJ
ecj-10810	139	40	reduction	reduction	NOUN
ecj-10810	139	41	thereafter	thereafter	ADV
ecj-10810	139	42	.	.	PUNCT
ecj-10810	140	1	noradrenaline	noradrenaline	PROPN
ecj-10810	140	2	is	be	AUX
ecj-10810	140	3	the	the	DET
ecj-10810	140	4	vasopressor	vasopressor	NOUN
ecj-10810	140	5	of	of	ADP
ecj-10810	140	6	choice	choice	NOUN
ecj-10810	140	7	and	and	CCONJ
ecj-10810	140	8	,	,	PUNCT
ecj-10810	140	9	when	when	SCONJ
ecj-10810	140	10	necessary	necessary	ADJ
ecj-10810	140	11	,	,	PUNCT
ecj-10810	140	12	it	it	PRON
ecj-10810	140	13	can	can	AUX
ecj-10810	140	14	be	be	AUX
ecj-10810	140	15	first	first	ADV
ecj-10810	140	16	administered	administer	VERB
ecj-10810	140	17	in	in	ADP
ecj-10810	140	18	a	a	DET
ecj-10810	140	19	peripheral	peripheral	ADJ
ecj-10810	140	20	vein.77	vein.77	NOUN
ecj-10810	140	21	the	the	DET
ecj-10810	140	22	addition	addition	NOUN
ecj-10810	140	23	of	of	ADP
ecj-10810	140	24	other	other	ADJ
ecj-10810	140	25	vasopressors	vasopressor	NOUN
ecj-10810	140	26	(	(	PUNCT
ecj-10810	140	27	adrenaline	adrenaline	NOUN
ecj-10810	140	28	or	or	CCONJ
ecj-10810	140	29	vasopressin	vasopressin	NOUN
ecj-10810	140	30	)	)	PUNCT
ecj-10810	140	31	is	be	AUX
ecj-10810	140	32	acceptable	acceptable	ADJ
ecj-10810	140	33	in	in	ADP
ecj-10810	140	34	patients	patient	NOUN
ecj-10810	140	35	who	who	PRON
ecj-10810	140	36	do	do	AUX
ecj-10810	140	37	not	not	PART
ecj-10810	140	38	respond	respond	VERB
ecj-10810	140	39	to	to	ADP
ecj-10810	140	40	noradrenaline	noradrenaline	NOUN
ecj-10810	140	41	.	.	PUNCT
ecj-10810	141	1	the	the	DET
ecj-10810	141	2	use	use	NOUN
ecj-10810	141	3	of	of	ADP
ecj-10810	141	4	inotropic	inotropic	ADJ
ecj-10810	141	5	drugs	drug	NOUN
ecj-10810	141	6	has	have	VERB
ecj-10810	141	7	a	a	DET
ecj-10810	141	8	rationale	rationale	NOUN
ecj-10810	141	9	in	in	ADP
ecj-10810	141	10	case	case	NOUN
ecj-10810	141	11	of	of	ADP
ecj-10810	141	12	left	left	ADJ
ecj-10810	141	13	ventricular	ventricular	ADJ
ecj-10810	141	14	insufficiency	insufficiency	NOUN
ecj-10810	141	15	and	and	CCONJ
ecj-10810	141	16	an	an	DET
ecj-10810	141	17	inadequate	inadequate	ADJ
ecj-10810	141	18	response	response	NOUN
ecj-10810	141	19	to	to	ADP
ecj-10810	141	20	fluids	fluid	NOUN
ecj-10810	141	21	and	and	CCONJ
ecj-10810	141	22	noradrenaline	noradrenaline	NOUN
ecj-10810	141	23	,	,	PUNCT
ecj-10810	141	24	although	although	SCONJ
ecj-10810	141	25	it	it	PRON
ecj-10810	141	26	is	be	AUX
ecj-10810	141	27	not	not	PART
ecj-10810	141	28	supported	support	VERB
ecj-10810	141	29	by	by	ADP
ecj-10810	141	30	appropriate	appropriate	ADJ
ecj-10810	141	31	clinical	clinical	ADJ
ecj-10810	141	32	trials	trial	NOUN
ecj-10810	141	33	.	.	PUNCT
ecj-10810	142	1	echocardiography	echocardiography	NOUN
ecj-10810	142	2	may	may	AUX
ecj-10810	142	3	help	help	VERB
ecj-10810	142	4	identify	identify	VERB
ecj-10810	142	5	patients	patient	NOUN
ecj-10810	142	6	that	that	PRON
ecj-10810	142	7	could	could	AUX
ecj-10810	142	8	better	well	ADV
ecj-10810	142	9	respond	respond	VERB
ecj-10810	142	10	to	to	ADP
ecj-10810	142	11	inotropes.78	inotropes.78	VERB
ecj-10810	142	12	this	this	DET
ecj-10810	142	13	treatment	treatment	NOUN
ecj-10810	142	14	,	,	PUNCT
ecj-10810	142	15	as	as	ADV
ecj-10810	142	16	well	well	ADV
ecj-10810	142	17	as	as	ADP
ecj-10810	142	18	the	the	DET
ecj-10810	142	19	administration	administration	NOUN
ecj-10810	142	20	of	of	ADP
ecj-10810	142	21	adrenaline	adrenaline	PROPN
ecj-10810	142	22	,	,	PUNCT
ecj-10810	142	23	should	should	AUX
ecj-10810	142	24	be	be	AUX
ecj-10810	142	25	constantly	constantly	ADV
ecj-10810	142	26	monitored	monitor	VERB
ecj-10810	142	27	and	and	CCONJ
ecj-10810	142	28	reserved	reserve	VERB
ecj-10810	142	29	for	for	ADP
ecj-10810	142	30	patients	patient	NOUN
ecj-10810	142	31	followed	follow	VERB
ecj-10810	142	32	in	in	ADP
ecj-10810	142	33	an	an	DET
ecj-10810	142	34	intensive	intensive	ADJ
ecj-10810	142	35	care	care	NOUN
ecj-10810	142	36	setting	setting	NOUN
ecj-10810	142	37	.	.	PUNCT
ecj-10810	143	1	since	since	SCONJ
ecj-10810	143	2	an	an	DET
ecj-10810	143	3	early	early	ADJ
ecj-10810	143	4	and	and	CCONJ
ecj-10810	143	5	appropriate	appropriate	ADJ
ecj-10810	143	6	antimicrobial	antimicrobial	ADJ
ecj-10810	143	7	treatment	treatment	NOUN
ecj-10810	143	8	has	have	VERB
ecj-10810	143	9	the	the	DET
ecj-10810	143	10	best	good	ADJ
ecj-10810	143	11	correlation	correlation	NOUN
ecj-10810	143	12	with	with	ADP
ecj-10810	143	13	prognosis	prognosis	NOUN
ecj-10810	143	14	,	,	PUNCT
ecj-10810	143	15	ed	ed	NOUN
ecj-10810	143	16	physicians	physician	NOUN
ecj-10810	143	17	should	should	AUX
ecj-10810	143	18	pay	pay	VERB
ecj-10810	143	19	the	the	DET
ecj-10810	143	20	utmost	utmost	ADJ
ecj-10810	143	21	attention	attention	NOUN
ecj-10810	143	22	to	to	ADP
ecj-10810	143	23	identifying	identify	VERB
ecj-10810	143	24	and	and	CCONJ
ecj-10810	143	25	possibly	possibly	ADV
ecj-10810	143	26	removing	remove	VERB
ecj-10810	143	27	the	the	DET
ecj-10810	143	28	source	source	NOUN
ecj-10810	143	29	of	of	ADP
ecj-10810	143	30	infection	infection	NOUN
ecj-10810	143	31	.	.	PUNCT
ecj-10810	144	1	early	early	ADJ
ecj-10810	144	2	cultures	culture	NOUN
ecj-10810	144	3	and	and	CCONJ
ecj-10810	144	4	initiation	initiation	NOUN
ecj-10810	144	5	of	of	ADP
ecj-10810	144	6	antibiotic	antibiotic	ADJ
ecj-10810	144	7	treatment	treatment	NOUN
ecj-10810	144	8	are	be	AUX
ecj-10810	144	9	also	also	ADV
ecj-10810	144	10	of	of	ADP
ecj-10810	144	11	paramount	paramount	ADJ
ecj-10810	144	12	importance	importance	NOUN
ecj-10810	144	13	.	.	PUNCT
ecj-10810	145	1	finally	finally	ADV
ecj-10810	145	2	,	,	PUNCT
ecj-10810	145	3	the	the	DET
ecj-10810	145	4	very	very	ADV
ecj-10810	145	5	frail	frail	ADJ
ecj-10810	145	6	patients	patient	NOUN
ecj-10810	145	7	in	in	ADP
ecj-10810	145	8	whom	whom	PRON
ecj-10810	145	9	sepsis	sepsis	NOUN
ecj-10810	145	10	is	be	AUX
ecj-10810	145	11	the	the	DET
ecj-10810	145	12	final	final	ADJ
ecj-10810	145	13	event	event	NOUN
ecj-10810	145	14	of	of	ADP
ecj-10810	145	15	advanced	advanced	ADJ
ecj-10810	145	16	chronic	chronic	ADJ
ecj-10810	145	17	disease	disease	NOUN
ecj-10810	145	18	should	should	AUX
ecj-10810	145	19	be	be	AUX
ecj-10810	145	20	spared	spare	VERB
ecj-10810	145	21	unnecessary	unnecessary	ADJ
ecj-10810	145	22	clinical	clinical	ADJ
ecj-10810	145	23	aggressiveness	aggressiveness	NOUN
ecj-10810	145	24	and	and	CCONJ
ecj-10810	145	25	be	be	AUX
ecj-10810	145	26	started	start	VERB
ecj-10810	145	27	on	on	ADP
ecj-10810	145	28	palliative	palliative	ADJ
ecj-10810	145	29	care	care	NOUN
ecj-10810	145	30	early	early	ADV
ecj-10810	145	31	.	.	PUNCT
ecj-10810	146	1	references	reference	NOUN
ecj-10810	146	2	1	1	NUM
ecj-10810	146	3	.	.	PUNCT
ecj-10810	146	4	bauer	bauer	PROPN
ecj-10810	146	5	m	m	PROPN
ecj-10810	146	6	,	,	PUNCT
ecj-10810	146	7	gerlach	gerlach	PROPN
ecj-10810	146	8	h	h	PROPN
ecj-10810	146	9	,	,	PUNCT
ecj-10810	146	10	vogelmann	vogelmann	PROPN
ecj-10810	146	11	t	t	PROPN
ecj-10810	146	12	,	,	PUNCT
ecj-10810	146	13	preissing	preisse	VERB
ecj-10810	146	14	f	f	PROPN
ecj-10810	146	15	,	,	PUNCT
ecj-10810	146	16	stiefel	stiefel	PROPN
ecj-10810	146	17	j	j	PROPN
ecj-10810	146	18	,	,	PUNCT
ecj-10810	146	19	adam	adam	PROPN
ecj-10810	146	20	d.	d.	PROPN
ecj-10810	146	21	mortality	mortality	PROPN
ecj-10810	146	22	in	in	ADP
ecj-10810	146	23	sepsis	sepsis	NOUN
ecj-10810	146	24	and	and	CCONJ
ecj-10810	146	25	septic	septic	ADJ
ecj-10810	146	26	shock	shock	NOUN
ecj-10810	146	27	in	in	ADP
ecj-10810	146	28	europe	europe	PROPN
ecj-10810	146	29	,	,	PUNCT
ecj-10810	146	30	north	north	PROPN
ecj-10810	146	31	america	america	PROPN
ecj-10810	146	32	and	and	CCONJ
ecj-10810	146	33	australia	australia	PROPN
ecj-10810	146	34	between	between	ADP
ecj-10810	146	35	2009	2009	NUM
ecj-10810	146	36	and	and	CCONJ
ecj-10810	146	37	2019results	2019results	NUM
ecj-10810	146	38	from	from	ADP
ecj-10810	146	39	a	a	DET
ecj-10810	146	40	systematic	systematic	ADJ
ecj-10810	146	41	review	review	NOUN
ecj-10810	146	42	and	and	CCONJ
ecj-10810	146	43	meta	meta	ADJ
ecj-10810	146	44	-	-	PUNCT
ecj-10810	146	45	analysis	analysis	NOUN
ecj-10810	146	46	.	.	PUNCT
ecj-10810	147	1	crit	crit	PROPN
ecj-10810	147	2	care	care	PROPN
ecj-10810	147	3	2020;24:239	2020;24:239	NUM
ecj-10810	147	4	.	.	NOUN
ecj-10810	148	1	2	2	NUM
ecj-10810	148	2	.	.	X
ecj-10810	149	1	lat	lat	INTJ
ecj-10810	150	1	i	i	PRON
ecj-10810	150	2	,	,	PUNCT
ecj-10810	150	3	coopersmith	coopersmith	PROPN
ecj-10810	150	4	cm	cm	PROPN
ecj-10810	150	5	,	,	PUNCT
ecj-10810	150	6	de	de	PROPN
ecj-10810	150	7	backer	backer	NOUN
ecj-10810	150	8	d.	d.	PROPN
ecj-10810	150	9	the	the	DET
ecj-10810	150	10	surviving	surviving	NOUN
ecj-10810	150	11	sepsis	sepsis	NOUN
ecj-10810	150	12	campaign	campaign	NOUN
ecj-10810	150	13	:	:	PUNCT
ecj-10810	150	14	fluid	fluid	ADJ
ecj-10810	150	15	resuscitation	resuscitation	NOUN
ecj-10810	150	16	and	and	CCONJ
ecj-10810	150	17	vasopressor	vasopressor	NOUN
ecj-10810	150	18	therapy	therapy	NOUN
ecj-10810	150	19	research	research	NOUN
ecj-10810	150	20	priorities	priority	NOUN
ecj-10810	150	21	in	in	ADP
ecj-10810	150	22	adult	adult	NOUN
ecj-10810	150	23	patients	patient	NOUN
ecj-10810	150	24	.	.	PUNCT
ecj-10810	151	1	crit	crit	PROPN
ecj-10810	151	2	care	care	PROPN
ecj-10810	151	3	med	med	PROPN
ecj-10810	151	4	2021;49	2021;49	NUM
ecj-10810	151	5	:	:	PUNCT
ecj-10810	151	6	review	review	NOUN
ecj-10810	152	1	[	[	X
ecj-10810	152	2	page	page	NOUN
ecj-10810	152	3	14	14	NUM
ecj-10810	152	4	]	]	PUNCT
ecj-10810	153	1	[	[	X
ecj-10810	153	2	emergency	emergency	NOUN
ecj-10810	153	3	care	care	NOUN
ecj-10810	153	4	journal	journal	NOUN
ecj-10810	153	5	2023	2023	NUM
ecj-10810	153	6	;	;	PUNCT
ecj-10810	153	7	19:10810	19:10810	X
ecj-10810	153	8	]	]	X
ecj-10810	153	9	non	non	ADJ
ecj-10810	153	10	-co	-co	PROPN
ecj-10810	153	11	mmerc	mmerc	PROPN
ecj-10810	153	12	ial	ial	PROPN
ecj-10810	153	13	us	us	PROPN
ecj-10810	153	14	e	e	NOUN
ecj-10810	153	15	o	o	NOUN
ecj-10810	153	16	nly	nly	ADV
ecj-10810	153	17	623	623	NUM
ecj-10810	153	18	-	-	SYM
ecj-10810	153	19	35	35	NUM
ecj-10810	153	20	.	.	PUNCT
ecj-10810	153	21	3	3	X
ecj-10810	153	22	.	.	X
ecj-10810	153	23	magder	magder	NOUN
ecj-10810	153	24	s.	s.	PROPN
ecj-10810	153	25	bench	bench	PROPN
ecj-10810	153	26	-	-	PUNCT
ecj-10810	153	27	to	to	ADP
ecj-10810	153	28	-	-	PUNCT
ecj-10810	153	29	bedside	bedside	NOUN
ecj-10810	153	30	review	review	NOUN
ecj-10810	153	31	:	:	PUNCT
ecj-10810	153	32	an	an	DET
ecj-10810	153	33	approach	approach	NOUN
ecj-10810	153	34	to	to	ADP
ecj-10810	153	35	hemodynamic	hemodynamic	ADJ
ecj-10810	153	36	monitoring	monitoring	NOUN
ecj-10810	153	37	--	--	PUNCT
ecj-10810	153	38	guyton	guyton	PROPN
ecj-10810	153	39	at	at	ADP
ecj-10810	153	40	the	the	DET
ecj-10810	153	41	bedside	bedside	NOUN
ecj-10810	153	42	.	.	PUNCT
ecj-10810	154	1	crit	crit	PROPN
ecj-10810	154	2	care	care	PROPN
ecj-10810	154	3	2012;16:236	2012;16:236	PROPN
ecj-10810	154	4	.	.	PROPN
ecj-10810	155	1	4	4	NUM
ecj-10810	155	2	.	.	X
ecj-10810	155	3	persichini	persichini	PROPN
ecj-10810	155	4	r	r	PROPN
ecj-10810	155	5	,	,	PUNCT
ecj-10810	155	6	lai	lai	NOUN
ecj-10810	155	7	c	c	AUX
ecj-10810	155	8	,	,	PUNCT
ecj-10810	155	9	teboul	teboul	PROPN
ecj-10810	155	10	jl	jl	PROPN
ecj-10810	155	11	,	,	PUNCT
ecj-10810	155	12	et	et	PROPN
ecj-10810	155	13	al	al	PROPN
ecj-10810	155	14	.	.	PUNCT
ecj-10810	156	1	venous	venous	ADJ
ecj-10810	156	2	return	return	NOUN
ecj-10810	156	3	and	and	CCONJ
ecj-10810	156	4	mean	mean	VERB
ecj-10810	156	5	systemic	systemic	ADJ
ecj-10810	156	6	filling	filling	NOUN
ecj-10810	156	7	pressure	pressure	NOUN
ecj-10810	156	8	:	:	PUNCT
ecj-10810	156	9	physiology	physiology	NOUN
ecj-10810	156	10	and	and	CCONJ
ecj-10810	156	11	clinical	clinical	ADJ
ecj-10810	156	12	applications	application	NOUN
ecj-10810	156	13	.	.	PUNCT
ecj-10810	157	1	crit	crit	PROPN
ecj-10810	157	2	care	care	PROPN
ecj-10810	157	3	2022;26:150	2022;26:150	PROPN
ecj-10810	157	4	.	.	PUNCT
ecj-10810	158	1	5	5	NUM
ecj-10810	158	2	.	.	X
ecj-10810	158	3	sato	sato	PROPN
ecj-10810	158	4	r	r	PROPN
ecj-10810	158	5	,	,	PUNCT
ecj-10810	158	6	nasu	nasu	PROPN
ecj-10810	158	7	m.	m.	NOUN
ecj-10810	158	8	a	a	DET
ecj-10810	158	9	review	review	NOUN
ecj-10810	158	10	of	of	ADP
ecj-10810	158	11	sepsis	sepsis	NOUN
ecj-10810	158	12	-	-	PUNCT
ecj-10810	158	13	induced	induce	VERB
ecj-10810	158	14	cardiomyopathy	cardiomyopathy	ADJ
ecj-10810	158	15	.	.	PUNCT
ecj-10810	159	1	j	j	PROPN
ecj-10810	159	2	intensive	intensive	ADJ
ecj-10810	159	3	care	care	NOUN
ecj-10810	159	4	2015;3:48	2015;3:48	NUM
ecj-10810	159	5	.	.	PUNCT
ecj-10810	160	1	6	6	NUM
ecj-10810	160	2	.	.	PUNCT
ecj-10810	160	3	l’heureux	l’heureux	PROPN
ecj-10810	160	4	m	m	PROPN
ecj-10810	160	5	,	,	PUNCT
ecj-10810	160	6	sternberg	sternberg	PROPN
ecj-10810	160	7	m	m	PROPN
ecj-10810	160	8	,	,	PUNCT
ecj-10810	160	9	brath	brath	PROPN
ecj-10810	160	10	l	l	PROPN
ecj-10810	160	11	,	,	PUNCT
ecj-10810	160	12	et	et	PROPN
ecj-10810	160	13	al	al	PROPN
ecj-10810	160	14	.	.	PROPN
ecj-10810	160	15	sepsis	sepsis	NOUN
ecj-10810	160	16	-	-	PUNCT
ecj-10810	160	17	induced	induce	VERB
ecj-10810	160	18	cardiomyopathy	cardiomyopathy	ADJ
ecj-10810	160	19	:	:	PUNCT
ecj-10810	160	20	a	a	DET
ecj-10810	160	21	comprehensive	comprehensive	ADJ
ecj-10810	160	22	review	review	NOUN
ecj-10810	160	23	.	.	PUNCT
ecj-10810	161	1	curr	curr	PROPN
ecj-10810	161	2	cardiol	cardiol	PROPN
ecj-10810	161	3	rep	rep	PROPN
ecj-10810	161	4	2020;22:35	2020;22:35	NUM
ecj-10810	161	5	.	.	PUNCT
ecj-10810	162	1	7	7	X
ecj-10810	162	2	.	.	X
ecj-10810	162	3	yadav	yadav	PROPN
ecj-10810	162	4	h	h	PROPN
ecj-10810	162	5	,	,	PUNCT
ecj-10810	162	6	cartin	cartin	NOUN
ecj-10810	162	7	-	-	PUNCT
ecj-10810	162	8	ceba	ceba	PROPN
ecj-10810	162	9	r.	r.	PROPN
ecj-10810	162	10	balance	balance	NOUN
ecj-10810	162	11	between	between	ADP
ecj-10810	162	12	hyperinflammation	hyperinflammation	NOUN
ecj-10810	162	13	and	and	CCONJ
ecj-10810	162	14	immunosuppression	immunosuppression	NOUN
ecj-10810	162	15	in	in	ADP
ecj-10810	162	16	sepsis	sepsis	NOUN
ecj-10810	162	17	.	.	PUNCT
ecj-10810	163	1	semin	semin	PROPN
ecj-10810	163	2	respir	respir	VERB
ecj-10810	163	3	crit	crit	PROPN
ecj-10810	163	4	care	care	NOUN
ecj-10810	163	5	med	me	VERB
ecj-10810	163	6	2016;37:42–50	2016;37:42–50	NUM
ecj-10810	163	7	.	.	PUNCT
ecj-10810	164	1	8	8	X
ecj-10810	164	2	.	.	X
ecj-10810	164	3	lee	lee	PROPN
ecj-10810	164	4	wl	wl	PROPN
ecj-10810	164	5	,	,	PUNCT
ecj-10810	164	6	slutsky	slutsky	PROPN
ecj-10810	164	7	as	as	ADP
ecj-10810	164	8	.	.	PROPN
ecj-10810	164	9	sepsis	sepsis	NOUN
ecj-10810	164	10	and	and	CCONJ
ecj-10810	164	11	endothelial	endothelial	NOUN
ecj-10810	164	12	permeability	permeability	NOUN
ecj-10810	164	13	.	.	PUNCT
ecj-10810	165	1	n	n	PROPN
ecj-10810	165	2	engl	engl	PROPN
ecj-10810	165	3	j	j	PROPN
ecj-10810	165	4	med	med	PROPN
ecj-10810	165	5	2010;363:689	2010;363:689	NUM
ecj-10810	165	6	-	-	SYM
ecj-10810	165	7	91	91	NUM
ecj-10810	165	8	.	.	PUNCT
ecj-10810	166	1	9	9	X
ecj-10810	166	2	.	.	X
ecj-10810	166	3	bentzer	bentzer	NOUN
ecj-10810	166	4	p	p	NOUN
ecj-10810	166	5	,	,	PUNCT
ecj-10810	166	6	griesdale	griesdale	ADJ
ecj-10810	166	7	de	de	PROPN
ecj-10810	166	8	,	,	PUNCT
ecj-10810	166	9	boyd	boyd	PROPN
ecj-10810	166	10	j	j	PROPN
ecj-10810	166	11	,	,	PUNCT
ecj-10810	166	12	et	et	PROPN
ecj-10810	166	13	al	al	PROPN
ecj-10810	166	14	.	.	PROPN
ecj-10810	166	15	will	will	AUX
ecj-10810	166	16	this	this	DET
ecj-10810	166	17	hemodynamically	hemodynamically	ADV
ecj-10810	166	18	unstable	unstable	ADJ
ecj-10810	166	19	patient	patient	NOUN
ecj-10810	166	20	respond	respond	NOUN
ecj-10810	166	21	to	to	ADP
ecj-10810	166	22	a	a	DET
ecj-10810	166	23	bolus	bolus	NOUN
ecj-10810	166	24	of	of	ADP
ecj-10810	166	25	intravenous	intravenous	ADJ
ecj-10810	166	26	fluids	fluid	NOUN
ecj-10810	166	27	?	?	PUNCT
ecj-10810	167	1	jama	jama	PROPN
ecj-10810	167	2	2016;316:1298	2016;316:1298	NUM
ecj-10810	167	3	-	-	PUNCT
ecj-10810	167	4	1309	1309	NUM
ecj-10810	167	5	.	.	PUNCT
ecj-10810	168	1	10	10	NUM
ecj-10810	168	2	.	.	X
ecj-10810	169	1	eskesen	eskesen	PROPN
ecj-10810	169	2	tg	tg	ADP
ecj-10810	169	3	,	,	PUNCT
ecj-10810	169	4	wetterslev	wetterslev	NOUN
ecj-10810	169	5	m	m	PROPN
ecj-10810	169	6	,	,	PUNCT
ecj-10810	169	7	perner	perner	NOUN
ecj-10810	169	8	a	a	DET
ecj-10810	169	9	:	:	PUNCT
ecj-10810	169	10	systematic	systematic	ADJ
ecj-10810	169	11	review	review	NOUN
ecj-10810	169	12	including	include	VERB
ecj-10810	169	13	re	re	NOUN
ecj-10810	169	14	-	-	NOUN
ecj-10810	169	15	analyses	analysis	NOUN
ecj-10810	169	16	of	of	ADP
ecj-10810	169	17	1148	1148	NUM
ecj-10810	169	18	individual	individual	ADJ
ecj-10810	169	19	data	datum	NOUN
ecj-10810	169	20	sets	set	NOUN
ecj-10810	169	21	of	of	ADP
ecj-10810	169	22	central	central	ADJ
ecj-10810	169	23	venous	venous	ADJ
ecj-10810	169	24	pressure	pressure	NOUN
ecj-10810	169	25	as	as	ADP
ecj-10810	169	26	a	a	DET
ecj-10810	169	27	predictor	predictor	NOUN
ecj-10810	169	28	of	of	ADP
ecj-10810	169	29	fluid	fluid	ADJ
ecj-10810	169	30	responsiveness	responsiveness	NOUN
ecj-10810	169	31	.	.	PUNCT
ecj-10810	170	1	intensive	intensive	ADJ
ecj-10810	170	2	care	care	NOUN
ecj-10810	170	3	med	me	VERB
ecj-10810	170	4	2016;42:324–32	2016;42:324–32	NUM
ecj-10810	170	5	.	.	PROPN
ecj-10810	171	1	11	11	NUM
ecj-10810	171	2	.	.	PUNCT
ecj-10810	172	1	airapetian	airapetian	PROPN
ecj-10810	172	2	n	n	CCONJ
ecj-10810	172	3	,	,	PUNCT
ecj-10810	172	4	maizel	maizel	PROPN
ecj-10810	172	5	j	j	PROPN
ecj-10810	172	6	,	,	PUNCT
ecj-10810	172	7	alyamani	alyamani	PROPN
ecj-10810	172	8	o	o	PROPN
ecj-10810	172	9	,	,	PUNCT
ecj-10810	172	10	et	et	PROPN
ecj-10810	172	11	al	al	PROPN
ecj-10810	172	12	.	.	PROPN
ecj-10810	172	13	does	do	AUX
ecj-10810	172	14	inferior	inferior	ADJ
ecj-10810	172	15	vena	vena	NOUN
ecj-10810	172	16	cava	cava	NOUN
ecj-10810	172	17	respiratory	respiratory	ADJ
ecj-10810	172	18	variability	variability	NOUN
ecj-10810	172	19	predict	predict	VERB
ecj-10810	172	20	fluid	fluid	ADJ
ecj-10810	172	21	responsiveness	responsiveness	NOUN
ecj-10810	172	22	in	in	ADP
ecj-10810	172	23	spontaneously	spontaneously	ADV
ecj-10810	172	24	breathing	breathe	VERB
ecj-10810	172	25	patients	patient	NOUN
ecj-10810	172	26	?	?	PUNCT
ecj-10810	173	1	critical	critical	ADJ
ecj-10810	173	2	care	care	NOUN
ecj-10810	173	3	2015;19:400	2015;19:400	NUM
ecj-10810	173	4	12	12	NUM
ecj-10810	173	5	.	.	PUNCT
ecj-10810	174	1	assessment	assessment	NOUN
ecj-10810	174	2	of	of	ADP
ecj-10810	174	3	sublingual	sublingual	ADJ
ecj-10810	174	4	microcirculation	microcirculation	NOUN
ecj-10810	174	5	in	in	ADP
ecj-10810	174	6	critically	critically	ADV
ecj-10810	174	7	ill	ill	ADJ
ecj-10810	174	8	patients	patient	NOUN
ecj-10810	174	9	:	:	PUNCT
ecj-10810	174	10	consensus	consensus	NOUN
ecj-10810	174	11	and	and	CCONJ
ecj-10810	174	12	debate	debate	NOUN
ecj-10810	174	13	.	.	PUNCT
ecj-10810	175	1	dilken	dilken	PROPN
ecj-10810	175	2	o	o	NOUN
ecj-10810	175	3	,	,	PUNCT
ecj-10810	175	4	ergin	ergin	NOUN
ecj-10810	175	5	b	b	NOUN
ecj-10810	175	6	,	,	PUNCT
ecj-10810	175	7	ince	ince	PROPN
ecj-10810	175	8	c.	c.	PROPN
ecj-10810	175	9	ann	ann	PROPN
ecj-10810	175	10	transl	transl	PROPN
ecj-10810	175	11	med	me	VERB
ecj-10810	175	12	2020;8:793	2020;8:793	NUM
ecj-10810	175	13	13	13	NUM
ecj-10810	175	14	.	.	PUNCT
ecj-10810	176	1	hernandez	hernandez	PROPN
ecj-10810	176	2	g	g	PROPN
ecj-10810	176	3	,	,	PUNCT
ecj-10810	176	4	bellomo	bellomo	PROPN
ecj-10810	176	5	r	r	PROPN
ecj-10810	176	6	,	,	PUNCT
ecj-10810	176	7	bakker	bakker	PROPN
ecj-10810	176	8	j.	j.	PROPN
ecj-10810	176	9	the	the	DET
ecj-10810	176	10	ten	ten	NUM
ecj-10810	176	11	pitfalls	pitfall	NOUN
ecj-10810	176	12	of	of	ADP
ecj-10810	176	13	lactate	lactate	NOUN
ecj-10810	176	14	clearance	clearance	NOUN
ecj-10810	176	15	in	in	ADP
ecj-10810	176	16	sepsis	sepsis	NOUN
ecj-10810	176	17	.	.	PUNCT
ecj-10810	177	1	intensive	intensive	ADJ
ecj-10810	177	2	care	care	NOUN
ecj-10810	177	3	med	med	ADJ
ecj-10810	177	4	2019;45:82	2019;45:82	NUM
ecj-10810	177	5	-	-	SYM
ecj-10810	177	6	85	85	NUM
ecj-10810	177	7	14	14	NUM
ecj-10810	177	8	.	.	PUNCT
ecj-10810	178	1	textoris	textoris	PROPN
ecj-10810	178	2	j	j	PROPN
ecj-10810	178	3	,	,	PUNCT
ecj-10810	178	4	fouché	fouché	ADJ
ecj-10810	178	5	l	l	NOUN
ecj-10810	178	6	,	,	PUNCT
ecj-10810	178	7	wiramus	wiramus	PROPN
ecj-10810	178	8	s	s	PROPN
ecj-10810	178	9	,	,	PUNCT
ecj-10810	178	10	et	et	PROPN
ecj-10810	178	11	al	al	PROPN
ecj-10810	178	12	.	.	PROPN
ecj-10810	179	1	high	high	ADJ
ecj-10810	179	2	central	central	ADJ
ecj-10810	179	3	venous	venous	ADJ
ecj-10810	179	4	oxygen	oxygen	NOUN
ecj-10810	179	5	saturation	saturation	NOUN
ecj-10810	179	6	in	in	ADP
ecj-10810	179	7	the	the	DET
ecj-10810	179	8	latter	latter	ADJ
ecj-10810	179	9	stages	stage	NOUN
ecj-10810	179	10	of	of	ADP
ecj-10810	179	11	septic	septic	ADJ
ecj-10810	179	12	shock	shock	NOUN
ecj-10810	179	13	is	be	AUX
ecj-10810	179	14	associated	associate	VERB
ecj-10810	179	15	with	with	ADP
ecj-10810	179	16	increased	increase	VERB
ecj-10810	179	17	mortality	mortality	NOUN
ecj-10810	179	18	.	.	PUNCT
ecj-10810	180	1	crit	crit	PROPN
ecj-10810	180	2	care	care	PROPN
ecj-10810	180	3	2011;15	2011;15	NUM
ecj-10810	180	4	:	:	PUNCT
ecj-10810	180	5	r176	r176	PROPN
ecj-10810	180	6	.	.	PROPN
ecj-10810	181	1	15	15	NUM
ecj-10810	181	2	.	.	PUNCT
ecj-10810	181	3	gattinoni	gattinoni	PROPN
ecj-10810	181	4	l	l	PROPN
ecj-10810	181	5	,	,	PUNCT
ecj-10810	181	6	vasques	vasque	NOUN
ecj-10810	181	7	f	f	NOUN
ecj-10810	181	8	,	,	PUNCT
ecj-10810	181	9	camporota	camporota	ADJ
ecj-10810	181	10	l	l	NOUN
ecj-10810	181	11	,	,	PUNCT
ecj-10810	181	12	et	et	PROPN
ecj-10810	181	13	al	al	PROPN
ecj-10810	181	14	.	.	PUNCT
ecj-10810	182	1	understanding	understand	VERB
ecj-10810	182	2	lactatemia	lactatemia	NOUN
ecj-10810	182	3	in	in	ADP
ecj-10810	182	4	human	human	ADJ
ecj-10810	182	5	sepsis	sepsis	NOUN
ecj-10810	182	6	:	:	PUNCT
ecj-10810	182	7	potential	potential	ADJ
ecj-10810	182	8	impact	impact	NOUN
ecj-10810	182	9	for	for	ADP
ecj-10810	182	10	marly	marly	ADJ
ecj-10810	182	11	management	management	NOUN
ecj-10810	182	12	.	.	PUNCT
ecj-10810	183	1	am	be	AUX
ecj-10810	183	2	j	j	PROPN
ecj-10810	183	3	respir	respir	NOUN
ecj-10810	183	4	crit	crit	PROPN
ecj-10810	183	5	care	care	NOUN
ecj-10810	183	6	med	me	VERB
ecj-10810	183	7	2019;200:582	2019;200:582	NUM
ecj-10810	183	8	-	-	SYM
ecj-10810	183	9	9	9	NUM
ecj-10810	183	10	.	.	NOUN
ecj-10810	183	11	16	16	NUM
ecj-10810	183	12	.	.	PUNCT
ecj-10810	184	1	vincent	vincent	PROPN
ecj-10810	184	2	jl	jl	PROPN
ecj-10810	184	3	,	,	PUNCT
ecj-10810	184	4	quintairos	quintairos	PROPN
ecj-10810	184	5	esa	esa	PROPN
ecj-10810	184	6	,	,	PUNCT
ecj-10810	184	7	couto	couto	PROPN
ecj-10810	184	8	l	l	PROPN
ecj-10810	184	9	jr	jr	PROPN
ecj-10810	184	10	,	,	PUNCT
ecj-10810	184	11	taccone	taccone	NOUN
ecj-10810	184	12	fs	fs	PROPN
ecj-10810	184	13	.	.	PUNCT
ecj-10810	185	1	the	the	DET
ecj-10810	185	2	value	value	NOUN
ecj-10810	185	3	of	of	ADP
ecj-10810	185	4	blood	blood	NOUN
ecj-10810	185	5	lactate	lactate	NOUN
ecj-10810	185	6	kinetics	kinetic	NOUN
ecj-10810	185	7	in	in	ADP
ecj-10810	185	8	critically	critically	ADV
ecj-10810	185	9	ill	ill	ADJ
ecj-10810	185	10	patients	patient	NOUN
ecj-10810	185	11	:	:	PUNCT
ecj-10810	185	12	a	a	DET
ecj-10810	185	13	systematic	systematic	ADJ
ecj-10810	185	14	review	review	NOUN
ecj-10810	185	15	.	.	PUNCT
ecj-10810	186	1	crit	crit	PROPN
ecj-10810	186	2	care	care	PROPN
ecj-10810	186	3	2016;20:257	2016;20:257	NUM
ecj-10810	186	4	17	17	NUM
ecj-10810	186	5	.	.	PUNCT
ecj-10810	187	1	yasufumi	yasufumi	PROPN
ecj-10810	187	2	o	o	PROPN
ecj-10810	187	3	,	,	PUNCT
ecj-10810	187	4	morimura	morimura	NOUN
ecj-10810	187	5	n	n	CCONJ
ecj-10810	187	6	,	,	PUNCT
ecj-10810	187	7	shirasawa	shirasawa	PROPN
ecj-10810	187	8	a	a	X
ecj-10810	187	9	,	,	PUNCT
ecj-10810	187	10	et	et	PROPN
ecj-10810	187	11	al	al	PROPN
ecj-10810	187	12	.	.	PROPN
ecj-10810	188	1	quantitative	quantitative	ADJ
ecj-10810	188	2	capillary	capillary	ADJ
ecj-10810	188	3	refill	refill	NOUN
ecj-10810	188	4	time	time	NOUN
ecj-10810	188	5	predicts	predict	NOUN
ecj-10810	188	6	sepsis	sepsis	NOUN
ecj-10810	188	7	in	in	ADP
ecj-10810	188	8	patients	patient	NOUN
ecj-10810	188	9	with	with	ADP
ecj-10810	188	10	suspected	suspect	VERB
ecj-10810	188	11	infection	infection	NOUN
ecj-10810	188	12	in	in	ADP
ecj-10810	188	13	the	the	DET
ecj-10810	188	14	emergency	emergency	NOUN
ecj-10810	188	15	department	department	NOUN
ecj-10810	188	16	:	:	PUNCT
ecj-10810	188	17	an	an	DET
ecj-10810	188	18	observational	observational	ADJ
ecj-10810	188	19	study	study	NOUN
ecj-10810	188	20	.	.	PUNCT
ecj-10810	189	1	j	j	PROPN
ecj-10810	189	2	intensive	intensive	ADJ
ecj-10810	189	3	care	care	PROPN
ecj-10810	189	4	2019;7:29	2019;7:29	NOUN
ecj-10810	189	5	18	18	NUM
ecj-10810	189	6	.	.	PUNCT
ecj-10810	190	1	castro	castro	PROPN
ecj-10810	190	2	r	r	PROPN
ecj-10810	190	3	,	,	PUNCT
ecj-10810	190	4	kattan	kattan	PROPN
ecj-10810	190	5	e	e	NOUN
ecj-10810	190	6	,	,	PUNCT
ecj-10810	190	7	ferri	ferri	PROPN
ecj-10810	190	8	g	g	PROPN
ecj-10810	190	9	,	,	PUNCT
ecj-10810	190	10	et	et	PROPN
ecj-10810	190	11	al	al	PROPN
ecj-10810	190	12	.	.	PUNCT
ecj-10810	190	13	effects	effect	NOUN
ecj-10810	190	14	of	of	ADP
ecj-10810	190	15	capillary	capillary	ADJ
ecj-10810	190	16	refill	refill	NOUN
ecj-10810	190	17	time	time	NOUN
ecj-10810	190	18	-	-	PUNCT
ecj-10810	190	19	vs.	vs.	NOUN
ecj-10810	190	20	lactate	lactate	NOUN
ecj-10810	190	21	-	-	PUNCT
ecj-10810	190	22	targeted	target	VERB
ecj-10810	190	23	fluid	fluid	ADJ
ecj-10810	190	24	resuscitation	resuscitation	NOUN
ecj-10810	190	25	on	on	ADP
ecj-10810	190	26	regional	regional	ADJ
ecj-10810	190	27	,	,	PUNCT
ecj-10810	190	28	microcirculatory	microcirculatory	ADJ
ecj-10810	190	29	and	and	CCONJ
ecj-10810	190	30	hypoxia	hypoxia	NOUN
ecj-10810	190	31	-	-	PUNCT
ecj-10810	190	32	related	relate	VERB
ecj-10810	190	33	perfusion	perfusion	NOUN
ecj-10810	190	34	parameters	parameter	NOUN
ecj-10810	190	35	in	in	ADP
ecj-10810	190	36	septic	septic	ADJ
ecj-10810	190	37	shock	shock	NOUN
ecj-10810	190	38	:	:	PUNCT
ecj-10810	190	39	a	a	DET
ecj-10810	190	40	randomized	randomized	ADJ
ecj-10810	190	41	controlled	control	VERB
ecj-10810	190	42	trial	trial	NOUN
ecj-10810	190	43	.	.	PUNCT
ecj-10810	191	1	ann	ann	PROPN
ecj-10810	191	2	intensive	intensive	ADJ
ecj-10810	191	3	care	care	NOUN
ecj-10810	191	4	2020;10:150	2020;10:150	PRON
ecj-10810	191	5	.	.	PUNCT
ecj-10810	192	1	19	19	NUM
ecj-10810	192	2	.	.	PUNCT
ecj-10810	192	3	zampieri	zampieri	PROPN
ecj-10810	192	4	fg	fg	PROPN
ecj-10810	192	5	,	,	PUNCT
ecj-10810	192	6	damiani	damiani	PROPN
ecj-10810	192	7	lp	lp	PROPN
ecj-10810	192	8	,	,	PUNCT
ecj-10810	192	9	bakker	bakker	PROPN
ecj-10810	192	10	j	j	PROPN
ecj-10810	192	11	,	,	PUNCT
ecj-10810	192	12	et	et	PROPN
ecj-10810	192	13	al	al	PROPN
ecj-10810	192	14	:	:	PUNCT
ecj-10810	192	15	effect	effect	NOUN
ecj-10810	192	16	of	of	ADP
ecj-10810	192	17	a	a	DET
ecj-10810	192	18	resuscitation	resuscitation	NOUN
ecj-10810	192	19	strategy	strategy	NOUN
ecj-10810	192	20	targeting	target	VERB
ecj-10810	192	21	peripheral	peripheral	ADJ
ecj-10810	192	22	perfusion	perfusion	NOUN
ecj-10810	192	23	status	status	NOUN
ecj-10810	192	24	vs	vs	ADP
ecj-10810	192	25	serum	serum	NOUN
ecj-10810	192	26	lactate	lactate	NOUN
ecj-10810	192	27	levels	level	NOUN
ecj-10810	192	28	on	on	ADP
ecj-10810	192	29	28	28	NUM
ecj-10810	192	30	-	-	PUNCT
ecj-10810	192	31	day	day	NOUN
ecj-10810	192	32	mortality	mortality	NOUN
ecj-10810	192	33	among	among	ADP
ecj-10810	192	34	patients	patient	NOUN
ecj-10810	192	35	with	with	ADP
ecj-10810	192	36	septic	septic	ADJ
ecj-10810	192	37	shock	shock	NOUN
ecj-10810	192	38	:	:	PUNCT
ecj-10810	192	39	a	a	DET
ecj-10810	192	40	bayesian	bayesian	NOUN
ecj-10810	192	41	reanalysis	reanalysis	NOUN
ecj-10810	192	42	of	of	ADP
ecj-10810	192	43	the	the	DET
ecj-10810	192	44	andromeda	andromeda	NOUN
ecj-10810	192	45	-	-	PUNCT
ecj-10810	192	46	shock	shock	NOUN
ecj-10810	192	47	trial	trial	NOUN
ecj-10810	192	48	.	.	PUNCT
ecj-10810	193	1	am	be	AUX
ecj-10810	193	2	j	j	PROPN
ecj-10810	193	3	respir	respir	NOUN
ecj-10810	193	4	crit	crit	PROPN
ecj-10810	193	5	care	care	NOUN
ecj-10810	193	6	med	med	PROPN
ecj-10810	193	7	2020;201:423–29	2020;201:423–29	PROPN
ecj-10810	193	8	.	.	PROPN
ecj-10810	193	9	20	20	NUM
ecj-10810	193	10	.	.	PUNCT
ecj-10810	194	1	magder	magder	PROPN
ecj-10810	194	2	s	s	PROPN
ecj-10810	194	3	,	,	PUNCT
ecj-10810	194	4	brengelmann	brengelmann	PROPN
ecj-10810	194	5	gl	gl	PROPN
ecj-10810	194	6	.	.	PROPN
ecj-10810	194	7	point	point	NOUN
ecj-10810	194	8	:	:	PUNCT
ecj-10810	194	9	counterpoint	counterpoint	NOUN
ecj-10810	194	10	:	:	PUNCT
ecj-10810	194	11	the	the	DET
ecj-10810	194	12	classic	classic	ADJ
ecj-10810	194	13	guyton	guyton	PROPN
ecj-10810	194	14	view	view	NOUN
ecj-10810	194	15	that	that	SCONJ
ecj-10810	194	16	mean	mean	VERB
ecj-10810	194	17	systemic	systemic	ADJ
ecj-10810	194	18	pressure	pressure	NOUN
ecj-10810	194	19	,	,	PUNCT
ecj-10810	194	20	right	right	ADJ
ecj-10810	194	21	atrial	atrial	ADJ
ecj-10810	194	22	pressure	pressure	NOUN
ecj-10810	194	23	,	,	PUNCT
ecj-10810	194	24	and	and	CCONJ
ecj-10810	194	25	venous	venous	ADJ
ecj-10810	194	26	resistance	resistance	NOUN
ecj-10810	194	27	govern	govern	VERB
ecj-10810	194	28	venous	venous	ADJ
ecj-10810	194	29	return	return	NOUN
ecj-10810	194	30	is	be	AUX
ecj-10810	194	31	/	/	PUNCT
ecj-10810	194	32	is	be	AUX
ecj-10810	194	33	not	not	PART
ecj-10810	194	34	correct	correct	ADJ
ecj-10810	194	35	.	.	PUNCT
ecj-10810	195	1	j	j	PROPN
ecj-10810	195	2	appl	appl	PROPN
ecj-10810	195	3	physiol	physiol	PROPN
ecj-10810	195	4	2006;101:1523–27	2006;101:1523–27	NUM
ecj-10810	195	5	.	.	PUNCT
ecj-10810	196	1	21	21	NUM
ecj-10810	196	2	.	.	PUNCT
ecj-10810	196	3	spiegel	spiegel	PROPN
ecj-10810	196	4	r.	r.	PROPN
ecj-10810	196	5	stressed	stress	VERB
ecj-10810	196	6	vs.	vs.	ADP
ecj-10810	196	7	unstressed	unstressed	ADJ
ecj-10810	196	8	volume	volume	NOUN
ecj-10810	196	9	and	and	CCONJ
ecj-10810	196	10	its	its	PRON
ecj-10810	196	11	relevance	relevance	NOUN
ecj-10810	196	12	to	to	ADP
ecj-10810	196	13	critical	critical	ADJ
ecj-10810	196	14	care	care	NOUN
ecj-10810	196	15	practitioners	practitioner	NOUN
ecj-10810	196	16	.	.	PUNCT
ecj-10810	197	1	clin	clin	PROPN
ecj-10810	197	2	exp	exp	PROPN
ecj-10810	197	3	emerg	emerg	PROPN
ecj-10810	197	4	med	med	ADJ
ecj-10810	197	5	2016;3:52	2016;3:52	NUM
ecj-10810	197	6	-	-	SYM
ecj-10810	197	7	4	4	NUM
ecj-10810	197	8	.	.	NOUN
ecj-10810	197	9	22	22	NUM
ecj-10810	197	10	.	.	PUNCT
ecj-10810	198	1	magder	magder	PROPN
ecj-10810	198	2	sa	sa	PROPN
ecj-10810	198	3	.	.	PUNCT
ecj-10810	199	1	the	the	DET
ecj-10810	199	2	highs	high	NOUN
ecj-10810	199	3	and	and	CCONJ
ecj-10810	199	4	lows	low	NOUN
ecj-10810	199	5	of	of	ADP
ecj-10810	199	6	blood	blood	NOUN
ecj-10810	199	7	pressure	pressure	NOUN
ecj-10810	199	8	:	:	PUNCT
ecj-10810	199	9	toward	toward	ADP
ecj-10810	199	10	meaningful	meaningful	ADJ
ecj-10810	199	11	clinical	clinical	ADJ
ecj-10810	199	12	targets	target	NOUN
ecj-10810	199	13	in	in	ADP
ecj-10810	199	14	patients	patient	NOUN
ecj-10810	199	15	with	with	ADP
ecj-10810	199	16	shock	shock	NOUN
ecj-10810	199	17	.	.	PUNCT
ecj-10810	200	1	crit	crit	PROPN
ecj-10810	200	2	care	care	PROPN
ecj-10810	200	3	med	med	PROPN
ecj-10810	200	4	2014;42:1241–51	2014;42:1241–51	NUM
ecj-10810	200	5	.	.	PUNCT
ecj-10810	201	1	23	23	NUM
ecj-10810	201	2	.	.	PUNCT
ecj-10810	202	1	carrara	carrara	PROPN
ecj-10810	202	2	m	m	PROPN
ecj-10810	202	3	,	,	PUNCT
ecj-10810	202	4	herpain	herpain	VERB
ecj-10810	202	5	a	a	PRON
ecj-10810	202	6	,	,	PUNCT
ecj-10810	202	7	baselli	baselli	PROPN
ecj-10810	202	8	g	g	PROPN
ecj-10810	202	9	,	,	PUNCT
ecj-10810	202	10	ferrario	ferrario	ADJ
ecj-10810	202	11	m.	m.	NOUN
ecj-10810	202	12	vascular	vascular	NOUN
ecj-10810	202	13	decoupling	decoupling	NOUN
ecj-10810	202	14	in	in	ADP
ecj-10810	202	15	septic	septic	ADJ
ecj-10810	202	16	shock	shock	NOUN
ecj-10810	202	17	:	:	PUNCT
ecj-10810	202	18	the	the	DET
ecj-10810	202	19	combined	combined	ADJ
ecj-10810	202	20	role	role	NOUN
ecj-10810	202	21	of	of	ADP
ecj-10810	202	22	autonomic	autonomic	ADJ
ecj-10810	202	23	nervous	nervous	ADJ
ecj-10810	202	24	system	system	NOUN
ecj-10810	202	25	,	,	PUNCT
ecj-10810	202	26	arterial	arterial	NOUN
ecj-10810	202	27	stiffness	stiffness	NOUN
ecj-10810	202	28	,	,	PUNCT
ecj-10810	202	29	and	and	CCONJ
ecj-10810	202	30	peripheral	peripheral	ADJ
ecj-10810	202	31	vascular	vascular	ADJ
ecj-10810	202	32	tone	tone	NOUN
ecj-10810	202	33	.	.	PUNCT
ecj-10810	203	1	front	front	ADJ
ecj-10810	203	2	physiol	physiol	PROPN
ecj-10810	203	3	2020;11:594	2020;11:594	PROPN
ecj-10810	203	4	.	.	PUNCT
ecj-10810	204	1	24	24	NUM
ecj-10810	204	2	.	.	PUNCT
ecj-10810	205	1	bayer	bayer	PROPN
ecj-10810	205	2	o	o	PROPN
ecj-10810	205	3	,	,	PUNCT
ecj-10810	205	4	reinhart	reinhart	PROPN
ecj-10810	205	5	k	k	PROPN
ecj-10810	205	6	,	,	PUNCT
ecj-10810	205	7	sakr	sakr	PROPN
ecj-10810	205	8	y	y	PROPN
ecj-10810	205	9	,	,	PUNCT
ecj-10810	205	10	et	et	PROPN
ecj-10810	205	11	al	al	PROPN
ecj-10810	205	12	.	.	PUNCT
ecj-10810	206	1	renal	renal	ADJ
ecj-10810	206	2	effects	effect	NOUN
ecj-10810	206	3	of	of	ADP
ecj-10810	206	4	synthetic	synthetic	ADJ
ecj-10810	206	5	colloids	colloid	NOUN
ecj-10810	206	6	and	and	CCONJ
ecj-10810	206	7	crystalloids	crystalloid	NOUN
ecj-10810	206	8	in	in	ADP
ecj-10810	206	9	patients	patient	NOUN
ecj-10810	206	10	with	with	ADP
ecj-10810	206	11	severe	severe	ADJ
ecj-10810	206	12	sepsis	sepsis	NOUN
ecj-10810	206	13	:	:	PUNCT
ecj-10810	206	14	a	a	DET
ecj-10810	206	15	prospective	prospective	ADJ
ecj-10810	206	16	sequential	sequential	ADJ
ecj-10810	206	17	comparison	comparison	NOUN
ecj-10810	206	18	.	.	PUNCT
ecj-10810	207	1	crit	crit	PROPN
ecj-10810	207	2	care	care	PROPN
ecj-10810	207	3	med	med	PROPN
ecj-10810	207	4	2011;39	2011;39	NUM
ecj-10810	207	5	:	:	PUNCT
ecj-10810	207	6	1335–42	1335–42	NUM
ecj-10810	207	7	.	.	PUNCT
ecj-10810	208	1	25	25	NUM
ecj-10810	208	2	.	.	PUNCT
ecj-10810	208	3	hammond	hammond	PROPN
ecj-10810	208	4	da	da	PROPN
ecj-10810	208	5	,	,	PUNCT
ecj-10810	208	6	lam	lam	PROPN
ecj-10810	208	7	sw	sw	PROPN
ecj-10810	208	8	,	,	PUNCT
ecj-10810	208	9	rech	rech	PROPN
ecj-10810	208	10	ma	ma	PROPN
ecj-10810	208	11	,	,	PUNCT
ecj-10810	208	12	et	et	PROPN
ecj-10810	208	13	al	al	PROPN
ecj-10810	208	14	.	.	PROPN
ecj-10810	209	1	balanced	balanced	ADJ
ecj-10810	209	2	crystalloids	crystalloid	NOUN
ecj-10810	209	3	versus	versus	ADP
ecj-10810	209	4	saline	saline	VERB
ecj-10810	209	5	in	in	ADP
ecj-10810	209	6	critically	critically	ADV
ecj-10810	209	7	ill	ill	ADJ
ecj-10810	209	8	adults	adult	NOUN
ecj-10810	209	9	:	:	PUNCT
ecj-10810	209	10	a	a	DET
ecj-10810	209	11	systematic	systematic	ADJ
ecj-10810	209	12	review	review	NOUN
ecj-10810	209	13	and	and	CCONJ
ecj-10810	209	14	meta	meta	ADJ
ecj-10810	209	15	-	-	PUNCT
ecj-10810	209	16	analysis	analysis	NOUN
ecj-10810	209	17	.	.	PUNCT
ecj-10810	210	1	ann	ann	PROPN
ecj-10810	210	2	pharmacother	pharmacother	PROPN
ecj-10810	210	3	2020;54:5–13	2020;54:5–13	NUM
ecj-10810	210	4	26	26	NUM
ecj-10810	210	5	.	.	PUNCT
ecj-10810	211	1	xue	xue	PROPN
ecj-10810	211	2	m	m	PROPN
ecj-10810	211	3	,	,	PUNCT
ecj-10810	211	4	zhang	zhang	PROPN
ecj-10810	211	5	x	x	PROPN
ecj-10810	211	6	,	,	PUNCT
ecj-10810	211	7	liu	liu	PROPN
ecj-10810	211	8	f	f	PROPN
ecj-10810	211	9	,	,	PUNCT
ecj-10810	211	10	et	et	PROPN
ecj-10810	211	11	al	al	PROPN
ecj-10810	211	12	:	:	PUNCT
ecj-10810	211	13	effects	effect	NOUN
ecj-10810	211	14	of	of	ADP
ecj-10810	211	15	chloride	chloride	NOUN
ecj-10810	211	16	content	content	NOUN
ecj-10810	211	17	of	of	ADP
ecj-10810	211	18	intravenous	intravenous	ADJ
ecj-10810	211	19	crystalloid	crystalloid	PROPN
ecj-10810	211	20	solutions	solution	NOUN
ecj-10810	211	21	in	in	ADP
ecj-10810	211	22	critically	critically	ADV
ecj-10810	211	23	ill	ill	ADJ
ecj-10810	211	24	adult	adult	NOUN
ecj-10810	211	25	patients	patient	NOUN
ecj-10810	211	26	:	:	PUNCT
ecj-10810	211	27	a	a	DET
ecj-10810	211	28	meta	meta	ADJ
ecj-10810	211	29	-	-	PUNCT
ecj-10810	211	30	analysis	analysis	NOUN
ecj-10810	211	31	with	with	ADP
ecj-10810	211	32	trial	trial	NOUN
ecj-10810	211	33	sequential	sequential	ADJ
ecj-10810	211	34	analysis	analysis	NOUN
ecj-10810	211	35	of	of	ADP
ecj-10810	211	36	randomized	randomized	ADJ
ecj-10810	211	37	trials	trial	NOUN
ecj-10810	211	38	.	.	PUNCT
ecj-10810	212	1	ann	ann	PROPN
ecj-10810	212	2	intensive	intensive	ADJ
ecj-10810	212	3	care	care	NOUN
ecj-10810	212	4	2019;9:30	2019;9:30	NOUN
ecj-10810	212	5	27	27	NUM
ecj-10810	212	6	.	.	PUNCT
ecj-10810	213	1	hammond	hammond	PROPN
ecj-10810	213	2	da	da	PROPN
ecj-10810	213	3	,	,	PUNCT
ecj-10810	213	4	lam	lam	PROPN
ecj-10810	213	5	sw	sw	PROPN
ecj-10810	213	6	,	,	PUNCT
ecj-10810	213	7	rech	rech	PROPN
ecj-10810	213	8	ma	ma	PROPN
ecj-10810	213	9	,	,	PUNCT
ecj-10810	213	10	et	et	PROPN
ecj-10810	213	11	al	al	PROPN
ecj-10810	213	12	.	.	PROPN
ecj-10810	214	1	balanced	balanced	ADJ
ecj-10810	214	2	crystalloids	crystalloid	NOUN
ecj-10810	214	3	versus	versus	ADP
ecj-10810	214	4	saline	saline	VERB
ecj-10810	214	5	in	in	ADP
ecj-10810	214	6	critically	critically	ADV
ecj-10810	214	7	ill	ill	ADJ
ecj-10810	214	8	adults	adult	NOUN
ecj-10810	214	9	:	:	PUNCT
ecj-10810	214	10	a	a	DET
ecj-10810	214	11	systematic	systematic	ADJ
ecj-10810	214	12	review	review	NOUN
ecj-10810	214	13	and	and	CCONJ
ecj-10810	214	14	meta	meta	ADJ
ecj-10810	214	15	-	-	PUNCT
ecj-10810	214	16	analysis	analysis	NOUN
ecj-10810	214	17	.	.	PUNCT
ecj-10810	215	1	ann	ann	PROPN
ecj-10810	215	2	pharmacother	pharmacother	PROPN
ecj-10810	215	3	2020;54:5	2020;54:5	PROPN
ecj-10810	215	4	-	-	SYM
ecj-10810	215	5	13	13	NUM
ecj-10810	215	6	.	.	PUNCT
ecj-10810	216	1	28	28	NUM
ecj-10810	216	2	.	.	PUNCT
ecj-10810	217	1	nunes	nunes	PROPN
ecj-10810	217	2	ts	ts	PROPN
ecj-10810	217	3	,	,	PUNCT
ecj-10810	217	4	ladeira	ladeira	PROPN
ecj-10810	217	5	rt	rt	PROPN
ecj-10810	217	6	,	,	PUNCT
ecj-10810	217	7	bafi	bafi	VERB
ecj-10810	217	8	at	at	ADP
ecj-10810	217	9	,	,	PUNCT
ecj-10810	217	10	et	et	PROPN
ecj-10810	217	11	al	al	PROPN
ecj-10810	217	12	.	.	PUNCT
ecj-10810	218	1	duration	duration	NOUN
ecj-10810	218	2	of	of	ADP
ecj-10810	218	3	hemodynamic	hemodynamic	ADJ
ecj-10810	218	4	effects	effect	NOUN
ecj-10810	218	5	of	of	ADP
ecj-10810	218	6	crystalloids	crystalloid	NOUN
ecj-10810	218	7	in	in	ADP
ecj-10810	218	8	patients	patient	NOUN
ecj-10810	218	9	with	with	ADP
ecj-10810	218	10	circulatory	circulatory	ADJ
ecj-10810	218	11	shock	shock	NOUN
ecj-10810	218	12	after	after	ADP
ecj-10810	218	13	initial	initial	ADJ
ecj-10810	218	14	resuscitation	resuscitation	NOUN
ecj-10810	218	15	.	.	PUNCT
ecj-10810	219	1	ann	ann	PROPN
ecj-10810	219	2	intensive	intensive	PROPN
ecj-10810	219	3	care	care	PROPN
ecj-10810	219	4	2014;4:25	2014;4:25	NOUN
ecj-10810	219	5	29	29	NUM
ecj-10810	219	6	.	.	PUNCT
ecj-10810	220	1	bentzer	bentzer	NOUN
ecj-10810	220	2	p	p	NOUN
ecj-10810	220	3	,	,	PUNCT
ecj-10810	220	4	griesdale	griesdale	ADJ
ecj-10810	220	5	de	de	PROPN
ecj-10810	220	6	,	,	PUNCT
ecj-10810	220	7	boyd	boyd	PROPN
ecj-10810	220	8	,	,	PUNCT
ecj-10810	220	9	j	j	PROPN
ecj-10810	220	10	,	,	PUNCT
ecj-10810	220	11	et	et	PROPN
ecj-10810	220	12	al	al	PROPN
ecj-10810	220	13	.	.	PROPN
ecj-10810	221	1	will	will	AUX
ecj-10810	221	2	this	this	DET
ecj-10810	221	3	hemodynamically	hemodynamically	ADV
ecj-10810	221	4	unstable	unstable	ADJ
ecj-10810	221	5	patient	patient	NOUN
ecj-10810	221	6	respond	respond	NOUN
ecj-10810	221	7	to	to	ADP
ecj-10810	221	8	a	a	DET
ecj-10810	221	9	bolus	bolus	NOUN
ecj-10810	221	10	of	of	ADP
ecj-10810	221	11	intravenous	intravenous	ADJ
ecj-10810	221	12	fluids	fluid	NOUN
ecj-10810	221	13	?	?	PUNCT
ecj-10810	222	1	jama	jama	PROPN
ecj-10810	222	2	2016;316:1298	2016;316:1298	NUM
ecj-10810	222	3	-	-	PUNCT
ecj-10810	222	4	1309	1309	NUM
ecj-10810	222	5	.	.	PUNCT
ecj-10810	223	1	30	30	NUM
ecj-10810	223	2	.	.	PUNCT
ecj-10810	224	1	preau	preau	PROPN
ecj-10810	224	2	s	s	PROPN
ecj-10810	224	3	,	,	PUNCT
ecj-10810	224	4	bortolotti	bortolotti	PROPN
ecj-10810	224	5	p	p	NOUN
ecj-10810	224	6	,	,	PUNCT
ecj-10810	224	7	colling	colling	NOUN
ecj-10810	224	8	d	d	PROPN
ecj-10810	224	9	,	,	PUNCT
ecj-10810	224	10	et	et	PROPN
ecj-10810	224	11	al.diagnostic	al.diagnostic	ADJ
ecj-10810	224	12	accuracy	accuracy	NOUN
ecj-10810	224	13	of	of	ADP
ecj-10810	224	14	the	the	DET
ecj-10810	224	15	inferior	inferior	ADJ
ecj-10810	224	16	vena	vena	NOUN
ecj-10810	224	17	cava	cava	NOUN
ecj-10810	224	18	collapsibility	collapsibility	NOUN
ecj-10810	224	19	to	to	PART
ecj-10810	224	20	predict	predict	VERB
ecj-10810	224	21	fluid	fluid	ADJ
ecj-10810	224	22	responsiveness	responsiveness	NOUN
ecj-10810	224	23	in	in	ADP
ecj-10810	224	24	spontaneously	spontaneously	ADV
ecj-10810	224	25	breathing	breathe	VERB
ecj-10810	224	26	patients	patient	NOUN
ecj-10810	224	27	with	with	ADP
ecj-10810	224	28	sepsis	sepsis	NOUN
ecj-10810	224	29	and	and	CCONJ
ecj-10810	224	30	acute	acute	ADJ
ecj-10810	224	31	circulatory	circulatory	ADJ
ecj-10810	224	32	failure	failure	NOUN
ecj-10810	224	33	.	.	PUNCT
ecj-10810	225	1	crit	crit	PROPN
ecj-10810	225	2	care	care	NOUN
ecj-10810	225	3	med	me	VERB
ecj-10810	225	4	2017;45	2017;45	NUM
ecj-10810	225	5	:	:	PUNCT
ecj-10810	225	6	e290–7	e290–7	PROPN
ecj-10810	225	7	.	.	PUNCT
ecj-10810	226	1	31	31	NUM
ecj-10810	226	2	.	.	PUNCT
ecj-10810	227	1	hernandez	hernandez	PROPN
ecj-10810	227	2	g	g	PROPN
ecj-10810	227	3	,	,	PUNCT
ecj-10810	227	4	teboul	teboul	PROPN
ecj-10810	227	5	jl	jl	PROPN
ecj-10810	227	6	,	,	PUNCT
ecj-10810	227	7	bakker	bakker	PROPN
ecj-10810	227	8	j.	j.	PROPN
ecj-10810	227	9	norepinephrine	norepinephrine	PROPN
ecj-10810	227	10	in	in	ADP
ecj-10810	227	11	septic	septic	ADJ
ecj-10810	227	12	shock	shock	NOUN
ecj-10810	227	13	.	.	PUNCT
ecj-10810	228	1	intensive	intensive	ADJ
ecj-10810	228	2	care	care	NOUN
ecj-10810	228	3	med	me	VERB
ecj-10810	228	4	2019;45:687–9	2019;45:687–9	NUM
ecj-10810	228	5	.	.	PUNCT
ecj-10810	229	1	32	32	NUM
ecj-10810	229	2	.	.	PUNCT
ecj-10810	230	1	avni	avni	PROPN
ecj-10810	230	2	t	t	PROPN
ecj-10810	230	3	,	,	PUNCT
ecj-10810	230	4	lador	lador	NOUN
ecj-10810	230	5	a	a	NOUN
ecj-10810	230	6	,	,	PUNCT
ecj-10810	230	7	lev	lev	NOUN
ecj-10810	230	8	s	s	PROPN
ecj-10810	230	9	,	,	PUNCT
ecj-10810	230	10	et	et	PROPN
ecj-10810	230	11	al	al	PROPN
ecj-10810	230	12	.	.	PROPN
ecj-10810	231	1	vasopressors	vasopressor	NOUN
ecj-10810	231	2	for	for	ADP
ecj-10810	231	3	the	the	DET
ecj-10810	231	4	treatment	treatment	NOUN
ecj-10810	231	5	of	of	ADP
ecj-10810	231	6	septic	septic	ADJ
ecj-10810	231	7	shock	shock	NOUN
ecj-10810	231	8	:	:	PUNCT
ecj-10810	231	9	systematic	systematic	ADJ
ecj-10810	231	10	review	review	NOUN
ecj-10810	231	11	and	and	CCONJ
ecj-10810	231	12	meta	meta	ADJ
ecj-10810	231	13	-	-	PUNCT
ecj-10810	231	14	analysis	analysis	NOUN
ecj-10810	231	15	.	.	PUNCT
ecj-10810	232	1	plos	plos	PROPN
ecj-10810	232	2	one	one	NUM
ecj-10810	232	3	2015;10	2015;10	NUM
ecj-10810	232	4	:	:	PUNCT
ecj-10810	232	5	e0129305	e0129305	ADJ
ecj-10810	232	6	.	.	PUNCT
ecj-10810	232	7	33	33	NUM
ecj-10810	232	8	.	.	PUNCT
ecj-10810	233	1	vasu	vasu	PROPN
ecj-10810	233	2	ts	ts	PROPN
ecj-10810	233	3	,	,	PUNCT
ecj-10810	233	4	cavallazzi	cavallazzi	ADJ
ecj-10810	233	5	r	r	NOUN
ecj-10810	233	6	,	,	PUNCT
ecj-10810	233	7	hirani	hirani	X
ecj-10810	233	8	a	a	PRON
ecj-10810	233	9	,	,	PUNCT
ecj-10810	233	10	et	et	PROPN
ecj-10810	233	11	al	al	PROPN
ecj-10810	233	12	.	.	PUNCT
ecj-10810	234	1	norepinephrine	norepinephrine	NOUN
ecj-10810	234	2	or	or	CCONJ
ecj-10810	234	3	dopamine	dopamine	VERB
ecj-10810	234	4	for	for	ADP
ecj-10810	234	5	septic	septic	ADJ
ecj-10810	234	6	shock	shock	NOUN
ecj-10810	234	7	:	:	PUNCT
ecj-10810	234	8	systematic	systematic	ADJ
ecj-10810	234	9	review	review	NOUN
ecj-10810	234	10	of	of	ADP
ecj-10810	234	11	randomized	randomized	ADJ
ecj-10810	234	12	clinical	clinical	ADJ
ecj-10810	234	13	trials	trial	NOUN
ecj-10810	234	14	.	.	PUNCT
ecj-10810	235	1	j	j	PROPN
ecj-10810	235	2	intensive	intensive	ADJ
ecj-10810	235	3	care	care	NOUN
ecj-10810	235	4	med	me	VERB
ecj-10810	235	5	2012;27:172	2012;27:172	NUM
ecj-10810	235	6	-	-	SYM
ecj-10810	235	7	8	8	NUM
ecj-10810	235	8	.	.	PUNCT
ecj-10810	236	1	34	34	NUM
ecj-10810	236	2	.	.	PUNCT
ecj-10810	237	1	uhel	uhel	PROPN
ecj-10810	238	1	f	f	PROPN
ecj-10810	238	2	,	,	PUNCT
ecj-10810	238	3	van	van	PROPN
ecj-10810	238	4	der	der	PROPN
ecj-10810	238	5	poll	poll	NOUN
ecj-10810	238	6	t.	t.	NOUN
ecj-10810	238	7	norepinephrine	norepinephrine	NOUN
ecj-10810	238	8	in	in	ADP
ecj-10810	238	9	septic	septic	ADJ
ecj-10810	238	10	shock	shock	NOUN
ecj-10810	238	11	:	:	PUNCT
ecj-10810	238	12	a	a	DET
ecj-10810	238	13	mixed	mixed	ADJ
ecj-10810	238	14	blessing	blessing	NOUN
ecj-10810	238	15	.	.	PUNCT
ecj-10810	239	1	am	be	AUX
ecj-10810	239	2	j	j	PROPN
ecj-10810	239	3	respir	respir	NOUN
ecj-10810	239	4	crit	crit	PROPN
ecj-10810	239	5	care	care	NOUN
ecj-10810	239	6	med	med	PROPN
ecj-10810	239	7	2020;202:788–9	2020;202:788–9	NUM
ecj-10810	239	8	.	.	PUNCT
ecj-10810	240	1	35	35	NUM
ecj-10810	240	2	.	.	PUNCT
ecj-10810	241	1	levy	levy	PROPN
ecj-10810	241	2	b	b	PROPN
ecj-10810	241	3	,	,	PUNCT
ecj-10810	241	4	collin	collin	PROPN
ecj-10810	241	5	s	s	PART
ecj-10810	241	6	,	,	PUNCT
ecj-10810	241	7	sennoun	sennoun	NOUN
ecj-10810	241	8	n	n	CCONJ
ecj-10810	241	9	,	,	PUNCT
ecj-10810	241	10	et	et	PROPN
ecj-10810	241	11	al	al	PROPN
ecj-10810	241	12	.	.	PUNCT
ecj-10810	242	1	vascular	vascular	ADJ
ecj-10810	242	2	hyporesponsiveness	hyporesponsiveness	NOUN
ecj-10810	242	3	to	to	ADP
ecj-10810	242	4	vasopressors	vasopressor	NOUN
ecj-10810	242	5	in	in	ADP
ecj-10810	242	6	septic	septic	ADJ
ecj-10810	242	7	shock	shock	NOUN
ecj-10810	242	8	:	:	PUNCT
ecj-10810	242	9	from	from	ADP
ecj-10810	242	10	bench	bench	NOUN
ecj-10810	242	11	to	to	ADP
ecj-10810	242	12	bedside	bedside	NOUN
ecj-10810	242	13	.	.	PUNCT
ecj-10810	243	1	intensive	intensive	ADJ
ecj-10810	243	2	care	care	NOUN
ecj-10810	243	3	med	med	PROPN
ecj-10810	243	4	2010;36:2019–29	2010;36:2019–29	NUM
ecj-10810	243	5	.	.	PUNCT
ecj-10810	244	1	36	36	NUM
ecj-10810	244	2	.	.	PUNCT
ecj-10810	245	1	hernandez	hernandez	PROPN
ecj-10810	245	2	g	g	PROPN
ecj-10810	245	3	,	,	PUNCT
ecj-10810	245	4	bruhn	bruhn	VERB
ecj-10810	245	5	a	a	X
ecj-10810	245	6	,	,	PUNCT
ecj-10810	245	7	luengo	luengo	PROPN
ecj-10810	245	8	c	c	NOUN
ecj-10810	245	9	,	,	PUNCT
ecj-10810	245	10	et	et	PROPN
ecj-10810	245	11	al	al	PROPN
ecj-10810	245	12	.	.	PUNCT
ecj-10810	246	1	effects	effect	NOUN
ecj-10810	246	2	of	of	ADP
ecj-10810	246	3	dobutamine	dobutamine	NOUN
ecj-10810	246	4	on	on	ADP
ecj-10810	246	5	systemic	systemic	ADJ
ecj-10810	246	6	,	,	PUNCT
ecj-10810	246	7	regional	regional	ADJ
ecj-10810	246	8	and	and	CCONJ
ecj-10810	246	9	microcirculatory	microcirculatory	ADJ
ecj-10810	246	10	perfusion	perfusion	NOUN
ecj-10810	246	11	parameters	parameter	NOUN
ecj-10810	246	12	.	.	PUNCT
ecj-10810	247	1	intensive	intensive	ADJ
ecj-10810	247	2	care	care	NOUN
ecj-10810	247	3	med	med	PROPN
ecj-10810	247	4	2013;39:1435–43	2013;39:1435–43	NUM
ecj-10810	247	5	.	.	PUNCT
ecj-10810	247	6	37	37	NUM
ecj-10810	247	7	.	.	PUNCT
ecj-10810	248	1	sato	sato	PROPN
ecj-10810	248	2	r	r	PROPN
ecj-10810	248	3	,	,	PUNCT
ecj-10810	248	4	nasu	nasu	PROPN
ecj-10810	248	5	m.	m.	NOUN
ecj-10810	248	6	time	time	NOUN
ecj-10810	248	7	to	to	PART
ecj-10810	248	8	re	re	VERB
ecj-10810	248	9	-	-	VERB
ecj-10810	248	10	think	think	VERB
ecj-10810	248	11	the	the	DET
ecj-10810	248	12	use	use	NOUN
ecj-10810	248	13	of	of	ADP
ecj-10810	248	14	dobutamine	dobutamine	NOUN
ecj-10810	248	15	in	in	ADP
ecj-10810	248	16	sepsis	sepsis	NOUN
ecj-10810	248	17	.	.	PUNCT
ecj-10810	249	1	j	j	PROPN
ecj-10810	249	2	intensive	intensive	ADJ
ecj-10810	249	3	care	care	NOUN
ecj-10810	249	4	2017;5:65	2017;5:65	NOUN
ecj-10810	249	5	.	.	PUNCT
ecj-10810	250	1	38	38	NUM
ecj-10810	250	2	.	.	PUNCT
ecj-10810	251	1	singer	singer	NOUN
ecj-10810	251	2	m	m	PROPN
ecj-10810	251	3	,	,	PUNCT
ecj-10810	251	4	inada	inada	PROPN
ecj-10810	251	5	-	-	PUNCT
ecj-10810	251	6	kim	kim	PROPN
ecj-10810	251	7	m	m	PROPN
ecj-10810	251	8	,	,	PUNCT
ecj-10810	251	9	shankar	shankar	PROPN
ecj-10810	251	10	-	-	PUNCT
ecj-10810	251	11	hari	hari	PROPN
ecj-10810	251	12	m.	m.	NOUN
ecj-10810	251	13	sepsis	sepsis	NOUN
ecj-10810	251	14	hysteria	hysteria	NOUN
ecj-10810	251	15	:	:	PUNCT
ecj-10810	251	16	excess	excess	ADJ
ecj-10810	251	17	hype	hype	NOUN
ecj-10810	251	18	and	and	CCONJ
ecj-10810	251	19	unrealistic	unrealistic	ADJ
ecj-10810	251	20	expectations	expectation	NOUN
ecj-10810	251	21	.	.	PUNCT
ecj-10810	252	1	lancet	lancet	NOUN
ecj-10810	252	2	2019;394	2019;394	NUM
ecj-10810	252	3	:	:	PUNCT
ecj-10810	252	4	1513	1513	NUM
ecj-10810	252	5	-	-	SYM
ecj-10810	252	6	14	14	NUM
ecj-10810	252	7	.	.	PUNCT
ecj-10810	253	1	39	39	NUM
ecj-10810	253	2	.	.	PUNCT
ecj-10810	254	1	rhee	rhee	PROPN
ecj-10810	254	2	c	c	PROPN
ecj-10810	254	3	,	,	PUNCT
ecj-10810	254	4	klompas	klompa	VERB
ecj-10810	254	5	m.	m.	NOUN
ecj-10810	254	6	sepsis	sepsis	NOUN
ecj-10810	254	7	trends	trend	NOUN
ecj-10810	254	8	:	:	PUNCT
ecj-10810	254	9	increasing	increase	VERB
ecj-10810	254	10	incidence	incidence	NOUN
ecj-10810	254	11	and	and	CCONJ
ecj-10810	254	12	decreasing	decrease	VERB
ecj-10810	254	13	mortality	mortality	NOUN
ecj-10810	254	14	,	,	PUNCT
ecj-10810	254	15	or	or	CCONJ
ecj-10810	254	16	changing	change	VERB
ecj-10810	254	17	denominator	denominator	NOUN
ecj-10810	254	18	?	?	PUNCT
ecj-10810	255	1	j	j	PROPN
ecj-10810	255	2	thorac	thorac	PROPN
ecj-10810	255	3	dis	dis	PROPN
ecj-10810	255	4	2020;12	2020;12	NUM
ecj-10810	255	5	:	:	PUNCT
ecj-10810	255	6	s89	s89	PROPN
ecj-10810	255	7	-	-	PUNCT
ecj-10810	255	8	s100	s100	PROPN
ecj-10810	255	9	.	.	PROPN
ecj-10810	256	1	40	40	NUM
ecj-10810	256	2	.	.	PUNCT
ecj-10810	257	1	rivers	river	NOUN
ecj-10810	257	2	e	e	PROPN
ecj-10810	257	3	,	,	PUNCT
ecj-10810	257	4	nguyen	nguyen	PROPN
ecj-10810	257	5	b	b	NUM
ecj-10810	257	6	,	,	PUNCT
ecj-10810	257	7	havstad	havstad	NOUN
ecj-10810	257	8	s	s	PROPN
ecj-10810	257	9	,	,	PUNCT
ecj-10810	257	10	et	et	PROPN
ecj-10810	257	11	al	al	PROPN
ecj-10810	257	12	.	.	PUNCT
ecj-10810	258	1	early	early	ADJ
ecj-10810	258	2	goal	goal	NOUN
ecj-10810	258	3	-	-	PUNCT
ecj-10810	258	4	directed	direct	VERB
ecj-10810	258	5	therapy	therapy	NOUN
ecj-10810	258	6	in	in	ADP
ecj-10810	258	7	the	the	DET
ecj-10810	258	8	treatment	treatment	NOUN
ecj-10810	258	9	of	of	ADP
ecj-10810	258	10	severe	severe	ADJ
ecj-10810	258	11	sepsis	sepsis	NOUN
ecj-10810	258	12	and	and	CCONJ
ecj-10810	258	13	septic	septic	ADJ
ecj-10810	258	14	shock	shock	NOUN
ecj-10810	258	15	.	.	PUNCT
ecj-10810	259	1	n	n	PROPN
ecj-10810	259	2	engl	engl	PROPN
ecj-10810	259	3	j	j	PROPN
ecj-10810	259	4	med	me	VERB
ecj-10810	259	5	2001;345:1368	2001;345:1368	PROPN
ecj-10810	259	6	-	-	SYM
ecj-10810	259	7	77	77	NUM
ecj-10810	259	8	.	.	PUNCT
ecj-10810	260	1	41	41	NUM
ecj-10810	260	2	.	.	PUNCT
ecj-10810	261	1	gao	gao	PROPN
ecj-10810	261	2	f	f	PROPN
ecj-10810	261	3	,	,	PUNCT
ecj-10810	261	4	melody	melody	PROPN
ecj-10810	261	5	t	t	PROPN
ecj-10810	261	6	,	,	PUNCT
ecj-10810	261	7	daniels	daniels	PROPN
ecj-10810	261	8	df	df	PROPN
ecj-10810	261	9	,	,	PUNCT
ecj-10810	261	10	et	et	PROPN
ecj-10810	261	11	al	al	PROPN
ecj-10810	261	12	.	.	PUNCT
ecj-10810	262	1	the	the	DET
ecj-10810	262	2	impact	impact	NOUN
ecj-10810	262	3	of	of	ADP
ecj-10810	262	4	compliance	compliance	NOUN
ecj-10810	262	5	with	with	ADP
ecj-10810	262	6	6	6	NUM
ecj-10810	262	7	-	-	PUNCT
ecj-10810	262	8	hour	hour	NOUN
ecj-10810	262	9	and24	and24	NOUN
ecj-10810	262	10	-	-	PUNCT
ecj-10810	262	11	hour	hour	NOUN
ecj-10810	262	12	sepsis	sepsis	NOUN
ecj-10810	262	13	bundles	bundle	NOUN
ecj-10810	262	14	on	on	ADP
ecj-10810	262	15	hospital	hospital	NOUN
ecj-10810	262	16	mortality	mortality	NOUN
ecj-10810	262	17	in	in	ADP
ecj-10810	262	18	patients	patient	NOUN
ecj-10810	262	19	with	with	ADP
ecj-10810	262	20	severe	severe	ADJ
ecj-10810	262	21	sepsis	sepsis	NOUN
ecj-10810	262	22	:	:	PUNCT
ecj-10810	262	23	a	a	DET
ecj-10810	262	24	prospective	prospective	ADJ
ecj-10810	262	25	observational	observational	ADJ
ecj-10810	262	26	study	study	NOUN
ecj-10810	262	27	.	.	PUNCT
ecj-10810	263	1	crit	crit	PROPN
ecj-10810	263	2	care	care	NOUN
ecj-10810	263	3	2005;9	2005;9	NUM
ecj-10810	263	4	:	:	PUNCT
ecj-10810	263	5	r764	r764	NUM
ecj-10810	263	6	-	-	SYM
ecj-10810	263	7	r770	r770	PROPN
ecj-10810	263	8	.	.	PROPN
ecj-10810	264	1	42	42	NUM
ecj-10810	264	2	.	.	PUNCT
ecj-10810	265	1	levy	levy	PROPN
ecj-10810	265	2	mm	mm	PROPN
ecj-10810	265	3	,	,	PUNCT
ecj-10810	265	4	dellinger	dellinger	NOUN
ecj-10810	265	5	rp	rp	NOUN
ecj-10810	265	6	,	,	PUNCT
ecj-10810	265	7	townsend	townsend	PROPN
ecj-10810	265	8	sr	sr	PROPN
ecj-10810	265	9	,	,	PUNCT
ecj-10810	265	10	et	et	PROPN
ecj-10810	265	11	al	al	PROPN
ecj-10810	265	12	.	.	PUNCT
ecj-10810	266	1	the	the	DET
ecj-10810	266	2	surviving	survive	VERB
ecj-10810	266	3	sepsis	sepsis	NOUN
ecj-10810	266	4	campaign	campaign	NOUN
ecj-10810	266	5	:	:	PUNCT
ecj-10810	266	6	results	result	NOUN
ecj-10810	266	7	of	of	ADP
ecj-10810	266	8	an	an	DET
ecj-10810	266	9	international	international	ADJ
ecj-10810	266	10	guideline	guideline	NOUN
ecj-10810	266	11	-	-	PUNCT
ecj-10810	266	12	based	base	VERB
ecj-10810	266	13	performance	performance	NOUN
ecj-10810	266	14	improvement	improvement	NOUN
ecj-10810	266	15	program	program	NOUN
ecj-10810	266	16	targeting	target	VERB
ecj-10810	266	17	severe	severe	ADJ
ecj-10810	266	18	sepsis	sepsis	NOUN
ecj-10810	266	19	.	.	PUNCT
ecj-10810	267	1	review	review	NOUN
ecj-10810	268	1	[	[	X
ecj-10810	268	2	emergency	emergency	NOUN
ecj-10810	268	3	care	care	NOUN
ecj-10810	268	4	journal	journal	NOUN
ecj-10810	268	5	2023	2023	NUM
ecj-10810	268	6	;	;	PUNCT
ecj-10810	268	7	19:10810	19:10810	NUM
ecj-10810	268	8	]	]	X
ecj-10810	269	1	[	[	X
ecj-10810	269	2	page	page	NOUN
ecj-10810	269	3	15	15	NUM
ecj-10810	269	4	]	]	X
ecj-10810	269	5	non	non	ADJ
ecj-10810	269	6	-co	-co	PROPN
ecj-10810	269	7	mmerc	mmerc	PROPN
ecj-10810	269	8	ial	ial	PROPN
ecj-10810	269	9	us	us	PROPN
ecj-10810	269	10	e	e	NOUN
ecj-10810	269	11	o	o	NOUN
ecj-10810	269	12	nly	nly	ADV
ecj-10810	269	13	crit	crit	VERB
ecj-10810	269	14	care	care	NOUN
ecj-10810	269	15	med	me	VERB
ecj-10810	269	16	2010;38:367	2010;38:367	NUM
ecj-10810	269	17	-	-	SYM
ecj-10810	269	18	74	74	NUM
ecj-10810	269	19	.	.	PUNCT
ecj-10810	269	20	43	43	NUM
ecj-10810	269	21	.	.	PUNCT
ecj-10810	270	1	rivers	river	NOUN
ecj-10810	270	2	e.	e.	PROPN
ecj-10810	270	3	implementation	implementation	NOUN
ecj-10810	270	4	of	of	ADP
ecj-10810	270	5	an	an	DET
ecj-10810	270	6	evidence	evidence	NOUN
ecj-10810	270	7	-	-	PUNCT
ecj-10810	270	8	based	base	VERB
ecj-10810	270	9	“	"	PUNCT
ecj-10810	270	10	standard	standard	ADJ
ecj-10810	270	11	operating	operating	NOUN
ecj-10810	270	12	procedure	procedure	NOUN
ecj-10810	270	13	”	"	PUNCT
ecj-10810	270	14	and	and	CCONJ
ecj-10810	270	15	outcome	outcome	VERB
ecj-10810	270	16	in	in	ADP
ecj-10810	270	17	septic	septic	ADJ
ecj-10810	270	18	shock	shock	NOUN
ecj-10810	270	19	:	:	PUNCT
ecj-10810	270	20	what	what	PRON
ecj-10810	270	21	a	a	DET
ecj-10810	270	22	sepsis	sepsis	NOUN
ecj-10810	270	23	pilot	pilot	NOUN
ecj-10810	270	24	must	must	AUX
ecj-10810	270	25	consider	consider	VERB
ecj-10810	270	26	before	before	ADP
ecj-10810	270	27	taking	take	VERB
ecj-10810	270	28	flight	flight	NOUN
ecj-10810	270	29	with	with	ADP
ecj-10810	270	30	your	your	PRON
ecj-10810	270	31	next	next	ADJ
ecj-10810	270	32	patient	patient	NOUN
ecj-10810	270	33	.	.	PUNCT
ecj-10810	271	1	crit	crit	PROPN
ecj-10810	271	2	care	care	PROPN
ecj-10810	271	3	med	med	PROPN
ecj-10810	271	4	2006;34:1247	2006;34:1247	NUM
ecj-10810	271	5	.	.	PROPN
ecj-10810	271	6	44	44	NUM
ecj-10810	271	7	.	.	PUNCT
ecj-10810	272	1	prasad	prasad	PROPN
ecj-10810	272	2	pa	pa	PROPN
ecj-10810	272	3	,	,	PUNCT
ecj-10810	272	4	shea	shea	PROPN
ecj-10810	272	5	er	er	INTJ
ecj-10810	272	6	,	,	PUNCT
ecj-10810	272	7	shiboski	shiboski	NOUN
ecj-10810	272	8	s	s	PROPN
ecj-10810	272	9	,	,	PUNCT
ecj-10810	272	10	et	et	PROPN
ecj-10810	272	11	al	al	PROPN
ecj-10810	272	12	.	.	PROPN
ecj-10810	272	13	relationship	relationship	NOUN
ecj-10810	272	14	between	between	ADP
ecj-10810	272	15	a	a	DET
ecj-10810	272	16	sepsis	sepsis	NOUN
ecj-10810	272	17	intervention	intervention	NOUN
ecj-10810	272	18	bundle	bundle	NOUN
ecj-10810	272	19	and	and	CCONJ
ecj-10810	272	20	in	in	ADP
ecj-10810	272	21	-	-	PUNCT
ecj-10810	272	22	hospital	hospital	NOUN
ecj-10810	272	23	mortality	mortality	NOUN
ecj-10810	272	24	among	among	ADP
ecj-10810	272	25	hospitalized	hospitalize	VERB
ecj-10810	272	26	patients	patient	NOUN
ecj-10810	272	27	:	:	PUNCT
ecj-10810	272	28	a	a	DET
ecj-10810	272	29	retrospective	retrospective	ADJ
ecj-10810	272	30	analysis	analysis	NOUN
ecj-10810	272	31	of	of	ADP
ecj-10810	272	32	real	real	ADJ
ecj-10810	272	33	-	-	PUNCT
ecj-10810	272	34	world	world	NOUN
ecj-10810	272	35	data	datum	NOUN
ecj-10810	272	36	.	.	PUNCT
ecj-10810	273	1	anesth	anesth	PROPN
ecj-10810	273	2	analg	analg	PROPN
ecj-10810	273	3	2017;125:507	2017;125:507	NUM
ecj-10810	273	4	-	-	SYM
ecj-10810	273	5	13	13	NUM
ecj-10810	273	6	.	.	PUNCT
ecj-10810	274	1	45	45	NUM
ecj-10810	274	2	.	.	PUNCT
ecj-10810	275	1	marik	marik	PROPN
ecj-10810	275	2	pe	pe	PROPN
ecj-10810	275	3	,	,	PUNCT
ecj-10810	275	4	cavallazzi	cavallazzi	PROPN
ecj-10810	275	5	r.	r.	PROPN
ecj-10810	275	6	does	do	AUX
ecj-10810	275	7	the	the	DET
ecj-10810	275	8	central	central	ADJ
ecj-10810	275	9	venous	venous	ADJ
ecj-10810	275	10	pressure	pressure	NOUN
ecj-10810	275	11	predict	predict	VERB
ecj-10810	275	12	fluid	fluid	ADJ
ecj-10810	275	13	responsiveness	responsiveness	NOUN
ecj-10810	275	14	?	?	PUNCT
ecj-10810	276	1	an	an	DET
ecj-10810	276	2	updated	update	VERB
ecj-10810	276	3	meta	meta	ADJ
ecj-10810	276	4	-	-	PUNCT
ecj-10810	276	5	analysis	analysis	NOUN
ecj-10810	276	6	and	and	CCONJ
ecj-10810	276	7	a	a	DET
ecj-10810	276	8	plea	plea	NOUN
ecj-10810	276	9	for	for	ADP
ecj-10810	276	10	some	some	DET
ecj-10810	276	11	common	common	ADJ
ecj-10810	276	12	sense	sense	NOUN
ecj-10810	276	13	.	.	PUNCT
ecj-10810	277	1	crit	crit	PROPN
ecj-10810	277	2	care	care	PROPN
ecj-10810	277	3	med	me	VERB
ecj-10810	277	4	2013;41:1774–81	2013;41:1774–81	NUM
ecj-10810	277	5	.	.	PUNCT
ecj-10810	278	1	46	46	NUM
ecj-10810	278	2	.	.	PUNCT
ecj-10810	279	1	kumar	kumar	PROPN
ecj-10810	279	2	a	a	PROPN
ecj-10810	279	3	,	,	PUNCT
ecj-10810	279	4	anel	anel	ADJ
ecj-10810	279	5	r	r	NOUN
ecj-10810	279	6	,	,	PUNCT
ecj-10810	279	7	bunnell	bunnell	PROPN
ecj-10810	279	8	e	e	PROPN
ecj-10810	279	9	,	,	PUNCT
ecj-10810	279	10	et	et	PROPN
ecj-10810	279	11	al	al	PROPN
ecj-10810	279	12	.	.	PUNCT
ecj-10810	279	13	pulmonary	pulmonary	ADJ
ecj-10810	279	14	artery	artery	NOUN
ecj-10810	279	15	occlusion	occlusion	NOUN
ecj-10810	279	16	pressure	pressure	NOUN
ecj-10810	279	17	and	and	CCONJ
ecj-10810	279	18	central	central	ADJ
ecj-10810	279	19	venous	venous	ADJ
ecj-10810	279	20	pressure	pressure	NOUN
ecj-10810	279	21	fail	fail	VERB
ecj-10810	279	22	to	to	PART
ecj-10810	279	23	predict	predict	VERB
ecj-10810	279	24	ventricular	ventricular	ADJ
ecj-10810	279	25	filling	filling	NOUN
ecj-10810	279	26	volume	volume	NOUN
ecj-10810	279	27	,	,	PUNCT
ecj-10810	279	28	cardiac	cardiac	ADJ
ecj-10810	279	29	performance	performance	NOUN
ecj-10810	279	30	,	,	PUNCT
ecj-10810	279	31	or	or	CCONJ
ecj-10810	279	32	the	the	DET
ecj-10810	279	33	response	response	NOUN
ecj-10810	279	34	to	to	PART
ecj-10810	279	35	volume	volume	VERB
ecj-10810	279	36	infusion	infusion	NOUN
ecj-10810	279	37	in	in	ADP
ecj-10810	279	38	normal	normal	ADJ
ecj-10810	279	39	subjects	subject	NOUN
ecj-10810	279	40	.	.	PUNCT
ecj-10810	280	1	crit	crit	PROPN
ecj-10810	280	2	care	care	PROPN
ecj-10810	280	3	med	med	PROPN
ecj-10810	280	4	2004;32:691–9	2004;32:691–9	NUM
ecj-10810	280	5	.	.	PUNCT
ecj-10810	281	1	47	47	NUM
ecj-10810	281	2	.	.	PUNCT
ecj-10810	282	1	delaney	delaney	PROPN
ecj-10810	282	2	a.	a.	PROPN
ecj-10810	282	3	protocolized	protocolized	PROPN
ecj-10810	282	4	sepsis	sepsis	NOUN
ecj-10810	282	5	care	care	NOUN
ecj-10810	282	6	is	be	AUX
ecj-10810	282	7	not	not	PART
ecj-10810	282	8	helpful	helpful	ADJ
ecj-10810	282	9	for	for	ADP
ecj-10810	282	10	patients	patient	NOUN
ecj-10810	282	11	.	.	PUNCT
ecj-10810	283	1	crit	crit	PROPN
ecj-10810	283	2	care	care	PROPN
ecj-10810	283	3	med	me	VERB
ecj-10810	283	4	2017;45:473	2017;45:473	PROPN
ecj-10810	283	5	-	-	SYM
ecj-10810	283	6	5	5	NUM
ecj-10810	283	7	.	.	NUM
ecj-10810	283	8	48	48	NUM
ecj-10810	283	9	.	.	PUNCT
ecj-10810	284	1	jones	jones	PROPN
ecj-10810	284	2	ae	ae	PROPN
ecj-10810	284	3	.	.	PUNCT
ecj-10810	285	1	unbundling	unbundle	VERB
ecj-10810	285	2	early	early	ADJ
ecj-10810	285	3	sepsis	sepsis	NOUN
ecj-10810	285	4	resuscitation	resuscitation	NOUN
ecj-10810	285	5	.	.	PUNCT
ecj-10810	286	1	ann	ann	PROPN
ecj-10810	286	2	emerg	emerg	PROPN
ecj-10810	286	3	med	me	VERB
ecj-10810	286	4	2014;63:654	2014;63:654	PROPN
ecj-10810	286	5	-	-	SYM
ecj-10810	286	6	5	5	NUM
ecj-10810	286	7	.	.	NUM
ecj-10810	286	8	49	49	NUM
ecj-10810	286	9	.	.	PUNCT
ecj-10810	287	1	rhodes	rhodes	PROPN
ecj-10810	287	2	a	a	PROPN
ecj-10810	287	3	,	,	PUNCT
ecj-10810	287	4	evans	evans	PROPN
ecj-10810	287	5	le	le	X
ecj-10810	287	6	,	,	PUNCT
ecj-10810	287	7	alhazzani	alhazzani	PROPN
ecj-10810	287	8	w	w	PROPN
ecj-10810	287	9	,	,	PUNCT
ecj-10810	287	10	et	et	PROPN
ecj-10810	287	11	al	al	PROPN
ecj-10810	287	12	.	.	PUNCT
ecj-10810	288	1	surviving	survive	VERB
ecj-10810	288	2	sepsis	sepsis	NOUN
ecj-10810	288	3	campaign	campaign	NOUN
ecj-10810	288	4	:	:	PUNCT
ecj-10810	288	5	international	international	ADJ
ecj-10810	288	6	guidelines	guideline	NOUN
ecj-10810	288	7	for	for	ADP
ecj-10810	288	8	the	the	DET
ecj-10810	288	9	management	management	NOUN
ecj-10810	288	10	of	of	ADP
ecj-10810	288	11	sepsis	sepsis	NOUN
ecj-10810	288	12	and	and	CCONJ
ecj-10810	288	13	septic	septic	ADJ
ecj-10810	288	14	shock	shock	NOUN
ecj-10810	288	15	:	:	PUNCT
ecj-10810	288	16	2016	2016	NUM
ecj-10810	288	17	.	.	PUNCT
ecj-10810	289	1	crit	crit	PROPN
ecj-10810	289	2	care	care	PROPN
ecj-10810	289	3	med	me	VERB
ecj-10810	289	4	2017;43:304–77	2017;43:304–77	NUM
ecj-10810	289	5	.	.	PROPN
ecj-10810	290	1	50	50	NUM
ecj-10810	290	2	.	.	PUNCT
ecj-10810	291	1	kalil	kalil	PROPN
ecj-10810	291	2	ac	ac	PROPN
ecj-10810	291	3	,	,	PUNCT
ecj-10810	291	4	johnson	johnson	PROPN
ecj-10810	291	5	dv	dv	PROPN
ecj-10810	291	6	,	,	PUNCT
ecj-10810	291	7	lisco	lisco	PROPN
ecj-10810	291	8	sj	sj	PROPN
ecj-10810	291	9	,	,	PUNCT
ecj-10810	291	10	su	su	PROPN
ecj-10810	291	11	jn	jn	PROPN
ecj-10810	291	12	.	.	PROPN
ecj-10810	292	1	early	early	ADJ
ecj-10810	292	2	goal	goal	NOUN
ecj-10810	292	3	-	-	PUNCT
ecj-10810	292	4	directed	direct	VERB
ecj-10810	292	5	therapy	therapy	NOUN
ecj-10810	292	6	for	for	ADP
ecj-10810	292	7	sepsis	sepsis	NOUN
ecj-10810	292	8	:	:	PUNCT
ecj-10810	292	9	a	a	DET
ecj-10810	292	10	novel	novel	ADJ
ecj-10810	292	11	solution	solution	NOUN
ecj-10810	292	12	for	for	ADP
ecj-10810	292	13	discordant	discordant	ADJ
ecj-10810	292	14	survival	survival	NOUN
ecj-10810	292	15	outcomes	outcome	NOUN
ecj-10810	292	16	in	in	ADP
ecj-10810	292	17	clinical	clinical	ADJ
ecj-10810	292	18	trials	trial	NOUN
ecj-10810	292	19	.	.	PUNCT
ecj-10810	293	1	crit	crit	PROPN
ecj-10810	293	2	care	care	PROPN
ecj-10810	293	3	med	med	PROPN
ecj-10810	293	4	2017;45:607–14	2017;45:607–14	PROPN
ecj-10810	293	5	.	.	PUNCT
ecj-10810	294	1	51	51	NUM
ecj-10810	294	2	.	.	PUNCT
ecj-10810	294	3	sakr	sakr	PROPN
ecj-10810	294	4	y	y	PROPN
ecj-10810	294	5	,	,	PUNCT
ecj-10810	294	6	rubatto	rubatto	ADJ
ecj-10810	294	7	birri	birri	NOUN
ecj-10810	294	8	pn	pn	PROPN
ecj-10810	294	9	,	,	PUNCT
ecj-10810	294	10	kotfis	kotfis	PROPN
ecj-10810	295	1	k	k	PROPN
ecj-10810	295	2	,	,	PUNCT
ecj-10810	295	3	et	et	PROPN
ecj-10810	295	4	al	al	PROPN
ecj-10810	295	5	.	.	PROPN
ecj-10810	295	6	intensive	intensive	ADJ
ecj-10810	295	7	care	care	NOUN
ecj-10810	295	8	over	over	ADP
ecj-10810	295	9	nations	nation	NOUN
ecj-10810	295	10	investigators	investigator	NOUN
ecj-10810	295	11	:	:	PUNCT
ecj-10810	295	12	higher	high	ADJ
ecj-10810	295	13	fluid	fluid	NOUN
ecj-10810	295	14	balance	balance	NOUN
ecj-10810	295	15	increases	increase	VERB
ecj-10810	295	16	the	the	DET
ecj-10810	295	17	risk	risk	NOUN
ecj-10810	295	18	of	of	ADP
ecj-10810	295	19	death	death	NOUN
ecj-10810	295	20	from	from	ADP
ecj-10810	295	21	sepsis	sepsis	NOUN
ecj-10810	295	22	:	:	PUNCT
ecj-10810	295	23	results	result	VERB
ecj-10810	295	24	from	from	ADP
ecj-10810	295	25	a	a	DET
ecj-10810	295	26	large	large	ADJ
ecj-10810	295	27	international	international	ADJ
ecj-10810	295	28	audit	audit	NOUN
ecj-10810	295	29	.	.	PUNCT
ecj-10810	296	1	crit	crit	PROPN
ecj-10810	296	2	care	care	PROPN
ecj-10810	296	3	med	med	PROPN
ecj-10810	296	4	2017;45:386–94	2017;45:386–94	X
ecj-10810	296	5	.	.	PROPN
ecj-10810	296	6	52	52	NUM
ecj-10810	296	7	.	.	PUNCT
ecj-10810	297	1	boyd	boyd	PROPN
ecj-10810	297	2	jh	jh	PROPN
ecj-10810	297	3	,	,	PUNCT
ecj-10810	297	4	forbes	forbes	PROPN
ecj-10810	297	5	j	j	PROPN
ecj-10810	297	6	,	,	PUNCT
ecj-10810	297	7	nakada	nakada	PROPN
ecj-10810	297	8	ta	ta	PROPN
ecj-10810	297	9	,	,	PUNCT
ecj-10810	297	10	et	et	PROPN
ecj-10810	297	11	al	al	PROPN
ecj-10810	297	12	.	.	PUNCT
ecj-10810	297	13	fluid	fluid	ADJ
ecj-10810	297	14	resuscitation	resuscitation	NOUN
ecj-10810	297	15	in	in	ADP
ecj-10810	297	16	septic	septic	ADJ
ecj-10810	297	17	shock	shock	NOUN
ecj-10810	297	18	:	:	PUNCT
ecj-10810	297	19	a	a	DET
ecj-10810	297	20	positive	positive	ADJ
ecj-10810	297	21	fluid	fluid	NOUN
ecj-10810	297	22	balance	balance	NOUN
ecj-10810	297	23	and	and	CCONJ
ecj-10810	297	24	elevated	elevated	ADJ
ecj-10810	297	25	central	central	ADJ
ecj-10810	297	26	venous	venous	ADJ
ecj-10810	297	27	pressure	pressure	NOUN
ecj-10810	297	28	are	be	AUX
ecj-10810	297	29	associated	associate	VERB
ecj-10810	297	30	with	with	ADP
ecj-10810	297	31	increased	increase	VERB
ecj-10810	297	32	mortality	mortality	NOUN
ecj-10810	297	33	.	.	PUNCT
ecj-10810	298	1	crit	crit	PROPN
ecj-10810	298	2	care	care	PROPN
ecj-10810	298	3	med	med	PROPN
ecj-10810	298	4	2011;39:259–265	2011;39:259–265	NOUN
ecj-10810	298	5	.	.	PUNCT
ecj-10810	299	1	53	53	NUM
ecj-10810	299	2	.	.	PUNCT
ecj-10810	299	3	kellum	kellum	PROPN
ecj-10810	299	4	ja	ja	PROPN
ecj-10810	299	5	,	,	PUNCT
ecj-10810	299	6	chawla	chawla	PROPN
ecj-10810	299	7	ls	ls	PROPN
ecj-10810	299	8	,	,	PUNCT
ecj-10810	299	9	keener	keener	NOUN
ecj-10810	299	10	c	c	NOUN
ecj-10810	299	11	,	,	PUNCT
ecj-10810	299	12	et	et	PROPN
ecj-10810	299	13	al	al	PROPN
ecj-10810	299	14	.	.	PROPN
ecj-10810	299	15	process	process	NOUN
ecj-10810	299	16	and	and	CCONJ
ecj-10810	299	17	progress	progress	NOUN
ecj-10810	299	18	-	-	PUNCT
ecj-10810	299	19	aki	aki	NOUN
ecj-10810	299	20	investigators.the	investigators.the	DET
ecj-10810	299	21	effects	effect	NOUN
ecj-10810	299	22	of	of	ADP
ecj-10810	299	23	alternative	alternative	ADJ
ecj-10810	299	24	resuscitation	resuscitation	NOUN
ecj-10810	299	25	strategies	strategy	NOUN
ecj-10810	299	26	on	on	ADP
ecj-10810	299	27	acute	acute	ADJ
ecj-10810	299	28	kidney	kidney	NOUN
ecj-10810	299	29	injury	injury	NOUN
ecj-10810	299	30	in	in	ADP
ecj-10810	299	31	patients	patient	NOUN
ecj-10810	299	32	with	with	ADP
ecj-10810	299	33	septic	septic	ADJ
ecj-10810	299	34	shock	shock	NOUN
ecj-10810	299	35	.	.	PUNCT
ecj-10810	300	1	am	be	AUX
ecj-10810	300	2	j	j	PROPN
ecj-10810	300	3	respir	respir	NOUN
ecj-10810	300	4	crit	crit	PROPN
ecj-10810	300	5	care	care	NOUN
ecj-10810	300	6	med	me	VERB
ecj-10810	300	7	2016;193:281	2016;193:281	NUM
ecj-10810	300	8	-	-	SYM
ecj-10810	300	9	7	7	NUM
ecj-10810	300	10	.	.	NUM
ecj-10810	300	11	54	54	NUM
ecj-10810	300	12	.	.	PUNCT
ecj-10810	301	1	mele	mele	PROPN
ecj-10810	301	2	a	a	DET
ecj-10810	301	3	,	,	PUNCT
ecj-10810	301	4	cerminara	cerminara	ADJ
ecj-10810	301	5	e	e	NOUN
ecj-10810	301	6	,	,	PUNCT
ecj-10810	301	7	häbel	häbel	PROPN
ecj-10810	301	8	h	h	PROPN
ecj-10810	301	9	,	,	PUNCT
ecj-10810	301	10	et	et	PROPN
ecj-10810	301	11	al	al	PROPN
ecj-10810	301	12	.	.	PUNCT
ecj-10810	301	13	fluid	fluid	ADJ
ecj-10810	301	14	accumulation	accumulation	NOUN
ecj-10810	301	15	and	and	CCONJ
ecj-10810	301	16	major	major	ADJ
ecj-10810	301	17	adverse	adverse	ADJ
ecj-10810	301	18	kidney	kidney	NOUN
ecj-10810	301	19	events	event	NOUN
ecj-10810	301	20	in	in	ADP
ecj-10810	301	21	sepsis	sepsis	NOUN
ecj-10810	301	22	:	:	PUNCT
ecj-10810	301	23	a	a	DET
ecj-10810	301	24	multicenter	multicenter	ADJ
ecj-10810	301	25	observational	observational	ADJ
ecj-10810	301	26	study	study	NOUN
ecj-10810	301	27	.	.	PUNCT
ecj-10810	302	1	ann	ann	PROPN
ecj-10810	302	2	intensive	intensive	ADJ
ecj-10810	302	3	care	care	PROPN
ecj-10810	302	4	2022;12:62	2022;12:62	NUM
ecj-10810	302	5	.	.	PUNCT
ecj-10810	303	1	55	55	NUM
ecj-10810	303	2	.	.	PUNCT
ecj-10810	304	1	arise	arise	VERB
ecj-10810	304	2	investigators	investigator	NOUN
ecj-10810	304	3	and	and	CCONJ
ecj-10810	304	4	the	the	DET
ecj-10810	304	5	anzics	anzic	NOUN
ecj-10810	304	6	clinical	clinical	ADJ
ecj-10810	304	7	trials	trial	NOUN
ecj-10810	304	8	group	group	NOUN
ecj-10810	304	9	.	.	PUNCT
ecj-10810	305	1	goal	goal	NOUN
ecj-10810	305	2	-	-	PUNCT
ecj-10810	305	3	directed	direct	VERB
ecj-10810	305	4	resuscitation	resuscitation	NOUN
ecj-10810	305	5	for	for	ADP
ecj-10810	305	6	patients	patient	NOUN
ecj-10810	305	7	with	with	ADP
ecj-10810	305	8	early	early	ADJ
ecj-10810	305	9	septic	septic	ADJ
ecj-10810	305	10	shock	shock	NOUN
ecj-10810	305	11	.	.	PUNCT
ecj-10810	306	1	n	n	PROPN
ecj-10810	306	2	engl	engl	PROPN
ecj-10810	306	3	j	j	PROPN
ecj-10810	306	4	med	me	VERB
ecj-10810	306	5	2014;371:1496	2014;371:1496	NOUN
ecj-10810	306	6	-	-	PUNCT
ecj-10810	306	7	506	506	NUM
ecj-10810	306	8	.	.	PUNCT
ecj-10810	307	1	56	56	NUM
ecj-10810	307	2	.	.	NOUN
ecj-10810	307	3	mouncey	mouncey	PROPN
ecj-10810	307	4	pr	pr	PROPN
ecj-10810	307	5	,	,	PUNCT
ecj-10810	307	6	osborn	osborn	PROPN
ecj-10810	307	7	tm	tm	PROPN
ecj-10810	307	8	,	,	PUNCT
ecj-10810	307	9	power	power	NOUN
ecj-10810	307	10	gs	gs	NOUN
ecj-10810	307	11	trial	trial	NOUN
ecj-10810	307	12	of	of	ADP
ecj-10810	307	13	early	early	ADJ
ecj-10810	307	14	,	,	PUNCT
ecj-10810	307	15	goaldirected	goaldirecte	VERB
ecj-10810	307	16	resuscitation	resuscitation	NOUN
ecj-10810	307	17	for	for	ADP
ecj-10810	307	18	septic	septic	ADJ
ecj-10810	307	19	shock	shock	NOUN
ecj-10810	307	20	.	.	PUNCT
ecj-10810	308	1	n	n	PROPN
ecj-10810	309	1	engl	engl	PROPN
ecj-10810	309	2	j	j	PROPN
ecj-10810	309	3	med	med	PROPN
ecj-10810	309	4	2015	2015	NUM
ecj-10810	309	5	;	;	PUNCT
ecj-10810	309	6	372:1301	372:1301	NUM
ecj-10810	309	7	-	-	SYM
ecj-10810	309	8	11	11	NUM
ecj-10810	309	9	.	.	PUNCT
ecj-10810	309	10	57	57	NUM
ecj-10810	309	11	.	.	PUNCT
ecj-10810	310	1	the	the	DET
ecj-10810	310	2	process	process	NOUN
ecj-10810	310	3	investigators	investigator	NOUN
ecj-10810	310	4	.	.	PUNCT
ecj-10810	311	1	a	a	DET
ecj-10810	311	2	randomized	randomized	ADJ
ecj-10810	311	3	trial	trial	NOUN
ecj-10810	311	4	of	of	ADP
ecj-10810	311	5	protocolbased	protocolbased	ADJ
ecj-10810	311	6	care	care	NOUN
ecj-10810	311	7	for	for	ADP
ecj-10810	311	8	early	early	ADJ
ecj-10810	311	9	septic	septic	ADJ
ecj-10810	311	10	shock	shock	NOUN
ecj-10810	311	11	.	.	PUNCT
ecj-10810	312	1	n	n	PROPN
ecj-10810	312	2	engl	engl	PROPN
ecj-10810	312	3	j	j	PROPN
ecj-10810	312	4	med	med	PROPN
ecj-10810	312	5	2014;370	2014;370	PROPN
ecj-10810	312	6	:	:	PUNCT
ecj-10810	312	7	1683	1683	NUM
ecj-10810	312	8	-	-	SYM
ecj-10810	312	9	93	93	NUM
ecj-10810	312	10	.	.	PUNCT
ecj-10810	313	1	58	58	NUM
ecj-10810	313	2	.	.	PUNCT
ecj-10810	314	1	meyhoff	meyhoff	PROPN
ecj-10810	314	2	ts	ts	PROPN
ecj-10810	314	3	,	,	PUNCT
ecj-10810	314	4	møller	møller	PROPN
ecj-10810	314	5	mh	mh	PROPN
ecj-10810	314	6	,	,	PUNCT
ecj-10810	314	7	hjortrup	hjortrup	NOUN
ecj-10810	314	8	pb	pb	PROPN
ecj-10810	314	9	,	,	PUNCT
ecj-10810	314	10	et	et	PROPN
ecj-10810	314	11	al	al	PROPN
ecj-10810	314	12	.	.	PROPN
ecj-10810	315	1	lower	low	ADJ
ecj-10810	315	2	vs	vs	ADP
ecj-10810	315	3	higher	high	ADJ
ecj-10810	315	4	fluid	fluid	ADJ
ecj-10810	315	5	volumes	volume	NOUN
ecj-10810	315	6	during	during	ADP
ecj-10810	315	7	initial	initial	ADJ
ecj-10810	315	8	management	management	NOUN
ecj-10810	315	9	of	of	ADP
ecj-10810	315	10	sepsis	sepsis	NOUN
ecj-10810	315	11	:	:	PUNCT
ecj-10810	315	12	a	a	DET
ecj-10810	315	13	systematic	systematic	ADJ
ecj-10810	315	14	review	review	NOUN
ecj-10810	315	15	with	with	ADP
ecj-10810	315	16	meta	meta	ADJ
ecj-10810	315	17	-	-	PUNCT
ecj-10810	315	18	analysis	analysis	NOUN
ecj-10810	315	19	and	and	CCONJ
ecj-10810	315	20	trial	trial	NOUN
ecj-10810	315	21	sequential	sequential	ADJ
ecj-10810	315	22	analysis	analysis	NOUN
ecj-10810	315	23	.	.	PUNCT
ecj-10810	316	1	chest	chest	NOUN
ecj-10810	316	2	2020;157:1478–96	2020;157:1478–96	NUM
ecj-10810	316	3	.	.	PUNCT
ecj-10810	317	1	59	59	NUM
ecj-10810	317	2	.	.	PUNCT
ecj-10810	318	1	hjortrup	hjortrup	PROPN
ecj-10810	318	2	pb	pb	PROPN
ecj-10810	318	3	,	,	PUNCT
ecj-10810	318	4	haase	haase	NOUN
ecj-10810	318	5	n	n	CCONJ
ecj-10810	318	6	,	,	PUNCT
ecj-10810	318	7	bundgaard	bundgaard	PROPN
ecj-10810	318	8	h	h	PROPN
ecj-10810	318	9	,	,	PUNCT
ecj-10810	318	10	et	et	PROPN
ecj-10810	318	11	al	al	PROPN
ecj-10810	318	12	.	.	PROPN
ecj-10810	318	13	classic	classic	ADJ
ecj-10810	318	14	trial	trial	NOUN
ecj-10810	318	15	group	group	NOUN
ecj-10810	318	16	;	;	PUNCT
ecj-10810	318	17	scandinavian	scandinavian	ADJ
ecj-10810	318	18	critical	critical	ADJ
ecj-10810	318	19	care	care	NOUN
ecj-10810	318	20	trials	trial	NOUN
ecj-10810	318	21	group	group	NOUN
ecj-10810	318	22	.	.	PUNCT
ecj-10810	319	1	restricting	restrict	VERB
ecj-10810	319	2	volumes	volume	NOUN
ecj-10810	319	3	of	of	ADP
ecj-10810	319	4	resuscitation	resuscitation	NOUN
ecj-10810	319	5	fluid	fluid	NOUN
ecj-10810	319	6	in	in	ADP
ecj-10810	319	7	adults	adult	NOUN
ecj-10810	319	8	with	with	ADP
ecj-10810	319	9	septic	septic	ADJ
ecj-10810	319	10	shock	shock	NOUN
ecj-10810	319	11	after	after	ADP
ecj-10810	319	12	initial	initial	ADJ
ecj-10810	319	13	management	management	NOUN
ecj-10810	319	14	:	:	PUNCT
ecj-10810	319	15	the	the	DET
ecj-10810	319	16	classic	classic	NOUN
ecj-10810	319	17	randomised	randomise	VERB
ecj-10810	319	18	,	,	PUNCT
ecj-10810	319	19	parallel	parallel	NOUN
ecj-10810	319	20	-	-	PUNCT
ecj-10810	319	21	group	group	NOUN
ecj-10810	319	22	,	,	PUNCT
ecj-10810	319	23	multicentre	multicentre	NOUN
ecj-10810	319	24	feasibility	feasibility	NOUN
ecj-10810	319	25	trial	trial	NOUN
ecj-10810	319	26	.	.	PUNCT
ecj-10810	320	1	intensive	intensive	ADJ
ecj-10810	320	2	care	care	NOUN
ecj-10810	320	3	med	me	VERB
ecj-10810	320	4	2016;42:1695	2016;42:1695	PROPN
ecj-10810	320	5	-	-	SYM
ecj-10810	320	6	705	705	NUM
ecj-10810	320	7	.	.	PUNCT
ecj-10810	321	1	60	60	NUM
ecj-10810	321	2	.	.	PUNCT
ecj-10810	322	1	meyhoff	meyhoff	PROPN
ecj-10810	322	2	ts	ts	PROPN
ecj-10810	322	3	,	,	PUNCT
ecj-10810	322	4	hjortrup	hjortrup	NOUN
ecj-10810	322	5	pb	pb	ADP
ecj-10810	322	6	,	,	PUNCT
ecj-10810	322	7	wetterslev	wetterslev	ADJ
ecj-10810	322	8	j	j	PROPN
ecj-10810	322	9	,	,	PUNCT
ecj-10810	322	10	et	et	PROPN
ecj-10810	322	11	al	al	PROPN
ecj-10810	322	12	.	.	PROPN
ecj-10810	322	13	restriction	restriction	NOUN
ecj-10810	322	14	of	of	ADP
ecj-10810	322	15	intravenous	intravenous	ADJ
ecj-10810	322	16	fluid	fluid	NOUN
ecj-10810	322	17	in	in	ADP
ecj-10810	322	18	icu	icu	PROPN
ecj-10810	322	19	patients	patient	NOUN
ecj-10810	322	20	with	with	ADP
ecj-10810	322	21	septic	septic	ADJ
ecj-10810	322	22	shock	shock	NOUN
ecj-10810	322	23	.	.	PUNCT
ecj-10810	323	1	n	n	PROPN
ecj-10810	323	2	engl	engl	PROPN
ecj-10810	323	3	j	j	PROPN
ecj-10810	323	4	med	med	PROPN
ecj-10810	323	5	2022;386:2459	2022;386:2459	PROPN
ecj-10810	323	6	-	-	SYM
ecj-10810	323	7	70	70	NUM
ecj-10810	323	8	.	.	PUNCT
ecj-10810	323	9	61	61	NUM
ecj-10810	323	10	.	.	PUNCT
ecj-10810	324	1	national	national	ADJ
ecj-10810	324	2	heart	heart	NOUN
ecj-10810	324	3	,	,	PUNCT
ecj-10810	324	4	lung	lung	NOUN
ecj-10810	324	5	,	,	PUNCT
ecj-10810	324	6	and	and	CCONJ
ecj-10810	324	7	blood	blood	NOUN
ecj-10810	324	8	institute	institute	PROPN
ecj-10810	324	9	prevention	prevention	PROPN
ecj-10810	324	10	and	and	CCONJ
ecj-10810	324	11	early	early	ADJ
ecj-10810	324	12	treatment	treatment	NOUN
ecj-10810	324	13	of	of	ADP
ecj-10810	324	14	acute	acute	ADJ
ecj-10810	324	15	lung	lung	NOUN
ecj-10810	324	16	injury	injury	NOUN
ecj-10810	324	17	clinical	clinical	ADJ
ecj-10810	324	18	trials	trial	NOUN
ecj-10810	324	19	network	network	NOUN
ecj-10810	324	20	;	;	PUNCT
ecj-10810	324	21	shapiro	shapiro	PROPN
ecj-10810	324	22	ni	ni	PROPN
ecj-10810	324	23	,	,	PUNCT
ecj-10810	324	24	douglas	douglas	PROPN
ecj-10810	324	25	is	be	AUX
ecj-10810	324	26	,	,	PUNCT
ecj-10810	324	27	et	et	PROPN
ecj-10810	324	28	al	al	PROPN
ecj-10810	324	29	.	.	PROPN
ecj-10810	325	1	early	early	ADV
ecj-10810	325	2	restrictive	restrictive	ADJ
ecj-10810	325	3	or	or	CCONJ
ecj-10810	325	4	liberal	liberal	ADJ
ecj-10810	325	5	fluid	fluid	ADJ
ecj-10810	325	6	management	management	NOUN
ecj-10810	325	7	for	for	ADP
ecj-10810	325	8	sepsis	sepsis	NOUN
ecj-10810	325	9	-	-	PUNCT
ecj-10810	325	10	induced	induce	VERB
ecj-10810	325	11	hypotension	hypotension	NOUN
ecj-10810	325	12	.	.	PUNCT
ecj-10810	326	1	n	n	CCONJ
ecj-10810	326	2	engl	engl	PROPN
ecj-10810	326	3	j	j	PROPN
ecj-10810	326	4	med	med	PROPN
ecj-10810	326	5	.	.	PUNCT
ecj-10810	327	1	2023;388:499	2023;388:499	NUM
ecj-10810	327	2	-	-	SYM
ecj-10810	327	3	510	510	NUM
ecj-10810	327	4	.	.	PUNCT
ecj-10810	327	5	62	62	NUM
ecj-10810	327	6	.	.	PUNCT
ecj-10810	328	1	hernandez	hernandez	PROPN
ecj-10810	328	2	g	g	PROPN
ecj-10810	328	3	,	,	PUNCT
ecj-10810	328	4	bruhn	bruhn	VERB
ecj-10810	328	5	a	a	PRON
ecj-10810	328	6	,	,	PUNCT
ecj-10810	328	7	castro	castro	PROPN
ecj-10810	328	8	r	r	NOUN
ecj-10810	328	9	,	,	PUNCT
ecj-10810	328	10	pedreros	pedrero	NOUN
ecj-10810	328	11	c	c	NOUN
ecj-10810	328	12	,	,	PUNCT
ecj-10810	328	13	et	et	PROPN
ecj-10810	328	14	al	al	PROPN
ecj-10810	328	15	.	.	PUNCT
ecj-10810	329	1	persistent	persistent	ADJ
ecj-10810	329	2	sepsis	sepsis	NOUN
ecj-10810	329	3	-	-	PUNCT
ecj-10810	329	4	induced	induce	VERB
ecj-10810	329	5	hypotension	hypotension	NOUN
ecj-10810	329	6	without	without	ADP
ecj-10810	329	7	hyperlactatemia	hyperlactatemia	ADV
ecj-10810	329	8	:	:	PUNCT
ecj-10810	329	9	a	a	DET
ecj-10810	329	10	distinct	distinct	ADJ
ecj-10810	329	11	clinical	clinical	ADJ
ecj-10810	329	12	and	and	CCONJ
ecj-10810	329	13	physiological	physiological	ADJ
ecj-10810	329	14	profile	profile	NOUN
ecj-10810	329	15	within	within	ADP
ecj-10810	329	16	the	the	DET
ecj-10810	329	17	spectrum	spectrum	NOUN
ecj-10810	329	18	of	of	ADP
ecj-10810	329	19	septic	septic	ADJ
ecj-10810	329	20	shock	shock	NOUN
ecj-10810	329	21	.	.	PUNCT
ecj-10810	330	1	crit	crit	PROPN
ecj-10810	330	2	care	care	PROPN
ecj-10810	330	3	res	res	PROPN
ecj-10810	330	4	pract	pract	PROPN
ecj-10810	330	5	2012;2012:536852	2012;2012:536852	NUM
ecj-10810	330	6	.	.	PUNCT
ecj-10810	331	1	63	63	NUM
ecj-10810	331	2	.	.	PUNCT
ecj-10810	332	1	jansen	jansen	PROPN
ecj-10810	332	2	tc	tc	PROPN
ecj-10810	332	3	,	,	PUNCT
ecj-10810	332	4	van	van	PROPN
ecj-10810	332	5	bommel	bommel	PROPN
ecj-10810	332	6	j	j	PROPN
ecj-10810	332	7	,	,	PUNCT
ecj-10810	332	8	schoonderbeek	schoonderbeek	VERB
ecj-10810	332	9	fj	fj	PROPN
ecj-10810	332	10	,	,	PUNCT
ecj-10810	332	11	et	et	PROPN
ecj-10810	332	12	al	al	PROPN
ecj-10810	332	13	.	.	PROPN
ecj-10810	333	1	early	early	ADJ
ecj-10810	333	2	lactate	lactate	NOUN
ecj-10810	333	3	-	-	PUNCT
ecj-10810	333	4	guided	guide	VERB
ecj-10810	333	5	therapy	therapy	NOUN
ecj-10810	333	6	in	in	ADP
ecj-10810	333	7	intensive	intensive	ADJ
ecj-10810	333	8	care	care	NOUN
ecj-10810	333	9	unit	unit	NOUN
ecj-10810	333	10	patients	patient	NOUN
ecj-10810	333	11	:	:	PUNCT
ecj-10810	333	12	a	a	DET
ecj-10810	333	13	multicenter	multicenter	NOUN
ecj-10810	333	14	,	,	PUNCT
ecj-10810	333	15	open	open	ADJ
ecj-10810	333	16	-	-	PUNCT
ecj-10810	333	17	label	label	NOUN
ecj-10810	333	18	,	,	PUNCT
ecj-10810	333	19	randomized	randomize	VERB
ecj-10810	333	20	controlled	control	VERB
ecj-10810	333	21	trial	trial	NOUN
ecj-10810	333	22	.	.	PUNCT
ecj-10810	334	1	am	be	AUX
ecj-10810	334	2	j	j	PROPN
ecj-10810	334	3	respir	respir	NOUN
ecj-10810	334	4	crit	crit	PROPN
ecj-10810	334	5	care	care	NOUN
ecj-10810	334	6	med	me	VERB
ecj-10810	334	7	2010;182:752	2010;182:752	NUM
ecj-10810	334	8	-	-	SYM
ecj-10810	334	9	61	61	NUM
ecj-10810	334	10	.	.	PUNCT
ecj-10810	335	1	64	64	NUM
ecj-10810	335	2	.	.	PUNCT
ecj-10810	336	1	hernandez	hernandez	PROPN
ecj-10810	336	2	g	g	PROPN
ecj-10810	336	3	,	,	PUNCT
ecj-10810	336	4	luengo	luengo	PROPN
ecj-10810	336	5	c	c	NOUN
ecj-10810	336	6	,	,	PUNCT
ecj-10810	336	7	bruhn	bruhn	VERB
ecj-10810	336	8	a	a	PRON
ecj-10810	336	9	,	,	PUNCT
ecj-10810	336	10	et	et	PROPN
ecj-10810	336	11	al	al	PROPN
ecj-10810	336	12	.	.	PUNCT
ecj-10810	337	1	when	when	SCONJ
ecj-10810	337	2	to	to	PART
ecj-10810	337	3	stop	stop	VERB
ecj-10810	337	4	septic	septic	ADJ
ecj-10810	337	5	shock	shock	NOUN
ecj-10810	337	6	resuscitation	resuscitation	NOUN
ecj-10810	337	7	:	:	PUNCT
ecj-10810	337	8	clues	clue	NOUN
ecj-10810	337	9	from	from	ADP
ecj-10810	337	10	a	a	DET
ecj-10810	337	11	dynamic	dynamic	ADJ
ecj-10810	337	12	perfusion	perfusion	NOUN
ecj-10810	337	13	monitoring	monitoring	NOUN
ecj-10810	337	14	.	.	PUNCT
ecj-10810	338	1	ann	ann	PROPN
ecj-10810	338	2	intensive	intensive	ADJ
ecj-10810	338	3	care	care	NOUN
ecj-10810	338	4	2014,4:30	2014,4:30	NOUN
ecj-10810	338	5	.	.	PUNCT
ecj-10810	339	1	65	65	NUM
ecj-10810	339	2	.	.	PUNCT
ecj-10810	340	1	hoste	hoste	PROPN
ecj-10810	340	2	ea	ea	PROPN
ecj-10810	340	3	,	,	PUNCT
ecj-10810	340	4	maitland	maitland	PROPN
ecj-10810	340	5	k	k	PROPN
ecj-10810	340	6	,	,	PUNCT
ecj-10810	340	7	brudney	brudney	PROPN
ecj-10810	340	8	cs	cs	PROPN
ecj-10810	340	9	,	,	PUNCT
ecj-10810	340	10	et	et	PROPN
ecj-10810	340	11	al	al	PROPN
ecj-10810	340	12	.	.	PROPN
ecj-10810	341	1	four	four	NUM
ecj-10810	341	2	phases	phase	NOUN
ecj-10810	341	3	of	of	ADP
ecj-10810	341	4	intravenous	intravenous	ADJ
ecj-10810	341	5	fluid	fluid	NOUN
ecj-10810	341	6	therapy	therapy	NOUN
ecj-10810	341	7	:	:	PUNCT
ecj-10810	341	8	a	a	DET
ecj-10810	341	9	conceptual	conceptual	ADJ
ecj-10810	341	10	model	model	NOUN
ecj-10810	341	11	.	.	PUNCT
ecj-10810	342	1	br	br	PROPN
ecj-10810	342	2	j	j	PROPN
ecj-10810	342	3	anaesth	anaesth	PROPN
ecj-10810	342	4	2014;113:740	2014;113:740	PROPN
ecj-10810	342	5	-	-	PUNCT
ecj-10810	342	6	7	7	NUM
ecj-10810	342	7	.	.	NUM
ecj-10810	342	8	66	66	NUM
ecj-10810	342	9	.	.	PUNCT
ecj-10810	343	1	malbrain	malbrain	PROPN
ecj-10810	343	2	mlng	mlng	PROPN
ecj-10810	343	3	,	,	PUNCT
ecj-10810	343	4	langer	langer	PROPN
ecj-10810	343	5	t	t	PROPN
ecj-10810	343	6	,	,	PUNCT
ecj-10810	343	7	annane	annane	NOUN
ecj-10810	343	8	d	d	PROPN
ecj-10810	343	9	,	,	PUNCT
ecj-10810	343	10	et	et	PROPN
ecj-10810	343	11	al	al	PROPN
ecj-10810	343	12	.	.	PROPN
ecj-10810	343	13	intravenous	intravenous	ADJ
ecj-10810	343	14	fluid	fluid	NOUN
ecj-10810	343	15	therapy	therapy	NOUN
ecj-10810	343	16	in	in	ADP
ecj-10810	343	17	the	the	DET
ecj-10810	343	18	perioperative	perioperative	ADJ
ecj-10810	343	19	and	and	CCONJ
ecj-10810	343	20	critical	critical	ADJ
ecj-10810	343	21	care	care	NOUN
ecj-10810	343	22	setting	setting	NOUN
ecj-10810	343	23	:	:	PUNCT
ecj-10810	343	24	executive	executive	ADJ
ecj-10810	343	25	summary	summary	NOUN
ecj-10810	343	26	of	of	ADP
ecj-10810	343	27	the	the	DET
ecj-10810	343	28	international	international	ADJ
ecj-10810	343	29	fluid	fluid	ADJ
ecj-10810	343	30	academy	academy	NOUN
ecj-10810	343	31	(	(	PUNCT
ecj-10810	343	32	ifa	ifa	PROPN
ecj-10810	343	33	)	)	PUNCT
ecj-10810	343	34	.	.	PUNCT
ecj-10810	344	1	ann	ann	PROPN
ecj-10810	344	2	intensive	intensive	PROPN
ecj-10810	344	3	care	care	PROPN
ecj-10810	344	4	2020;10:64	2020;10:64	NUM
ecj-10810	344	5	.	.	PUNCT
ecj-10810	345	1	67	67	NUM
ecj-10810	345	2	.	.	PUNCT
ecj-10810	346	1	avni	avni	PROPN
ecj-10810	346	2	t	t	PROPN
ecj-10810	346	3	,	,	PUNCT
ecj-10810	346	4	lador	lador	NOUN
ecj-10810	346	5	a	a	NOUN
ecj-10810	346	6	,	,	PUNCT
ecj-10810	346	7	lev	lev	NOUN
ecj-10810	346	8	s	s	PROPN
ecj-10810	346	9	,	,	PUNCT
ecj-10810	346	10	et	et	PROPN
ecj-10810	346	11	al	al	PROPN
ecj-10810	346	12	.	.	PROPN
ecj-10810	347	1	vasopressors	vasopressor	NOUN
ecj-10810	347	2	for	for	ADP
ecj-10810	347	3	the	the	DET
ecj-10810	347	4	treatment	treatment	NOUN
ecj-10810	347	5	of	of	ADP
ecj-10810	347	6	septic	septic	ADJ
ecj-10810	347	7	shock	shock	NOUN
ecj-10810	347	8	:	:	PUNCT
ecj-10810	347	9	systematic	systematic	ADJ
ecj-10810	347	10	review	review	NOUN
ecj-10810	347	11	and	and	CCONJ
ecj-10810	347	12	meta	meta	ADJ
ecj-10810	347	13	-	-	PUNCT
ecj-10810	347	14	analysis	analysis	NOUN
ecj-10810	347	15	.	.	PUNCT
ecj-10810	348	1	plos	plos	PROPN
ecj-10810	348	2	one	one	NUM
ecj-10810	348	3	2015;10	2015;10	NUM
ecj-10810	348	4	:	:	PUNCT
ecj-10810	348	5	e0129305	e0129305	ADJ
ecj-10810	348	6	.	.	PUNCT
ecj-10810	348	7	68	68	NUM
ecj-10810	348	8	.	.	PUNCT
ecj-10810	349	1	permpikul	permpikul	PROPN
ecj-10810	349	2	c	c	NOUN
ecj-10810	349	3	,	,	PUNCT
ecj-10810	349	4	tongyoo	tongyoo	PROPN
ecj-10810	349	5	s	s	PART
ecj-10810	349	6	,	,	PUNCT
ecj-10810	349	7	viarasilpa	viarasilpa	PROPN
ecj-10810	349	8	t	t	PROPN
ecj-10810	349	9	,	,	PUNCT
ecj-10810	349	10	et	et	PROPN
ecj-10810	349	11	al	al	PROPN
ecj-10810	349	12	.	.	PUNCT
ecj-10810	350	1	early	early	ADJ
ecj-10810	350	2	use	use	NOUN
ecj-10810	350	3	of	of	ADP
ecj-10810	350	4	norepinephrine	norepinephrine	NOUN
ecj-10810	350	5	in	in	ADP
ecj-10810	350	6	septic	septic	ADJ
ecj-10810	350	7	shock	shock	NOUN
ecj-10810	350	8	resuscitation	resuscitation	NOUN
ecj-10810	350	9	(	(	PUNCT
ecj-10810	350	10	censer	censer	NOUN
ecj-10810	350	11	):	):	PUNCT
ecj-10810	350	12	a	a	DET
ecj-10810	350	13	randomized	randomized	ADJ
ecj-10810	350	14	trial	trial	NOUN
ecj-10810	350	15	.	.	PUNCT
ecj-10810	351	1	am	be	AUX
ecj-10810	351	2	j	j	PROPN
ecj-10810	351	3	resp	resp	PROPN
ecj-10810	351	4	crit	crit	PROPN
ecj-10810	351	5	care	care	PROPN
ecj-10810	351	6	medicine	medicine	NOUN
ecj-10810	351	7	2019;199:1097	2019;199:1097	NUM
ecj-10810	351	8	-	-	SYM
ecj-10810	351	9	05	05	NUM
ecj-10810	351	10	.	.	PROPN
ecj-10810	352	1	69	69	NUM
ecj-10810	352	2	.	.	PUNCT
ecj-10810	353	1	li	li	PROPN
ecj-10810	353	2	y	y	PROPN
ecj-10810	353	3	,	,	PUNCT
ecj-10810	353	4	li	li	PROPN
ecj-10810	353	5	h	h	PROPN
ecj-10810	353	6	,	,	PUNCT
ecj-10810	353	7	zhang	zhang	PROPN
ecj-10810	353	8	d.	d.	PROPN
ecj-10810	353	9	timing	timing	PROPN
ecj-10810	353	10	of	of	ADP
ecj-10810	353	11	norepinephrine	norepinephrine	ADJ
ecj-10810	353	12	initiation	initiation	NOUN
ecj-10810	353	13	in	in	ADP
ecj-10810	353	14	patients	patient	NOUN
ecj-10810	353	15	with	with	ADP
ecj-10810	353	16	septic	septic	ADJ
ecj-10810	353	17	shock	shock	NOUN
ecj-10810	353	18	:	:	PUNCT
ecj-10810	353	19	a	a	DET
ecj-10810	353	20	systematic	systematic	ADJ
ecj-10810	353	21	review	review	NOUN
ecj-10810	353	22	and	and	CCONJ
ecj-10810	353	23	meta	meta	ADJ
ecj-10810	353	24	-	-	PUNCT
ecj-10810	353	25	analysis	analysis	NOUN
ecj-10810	353	26	.	.	PUNCT
ecj-10810	354	1	critical	critical	ADJ
ecj-10810	354	2	care	care	NOUN
ecj-10810	354	3	2020;24:488	2020;24:488	NUM
ecj-10810	354	4	.	.	PUNCT
ecj-10810	355	1	70	70	NUM
ecj-10810	355	2	.	.	PUNCT
ecj-10810	356	1	waechter	waechter	PROPN
ecj-10810	356	2	j	j	PROPN
ecj-10810	356	3	,	,	PUNCT
ecj-10810	356	4	kumar	kumar	PROPN
ecj-10810	356	5	a	a	PROPN
ecj-10810	356	6	,	,	PUNCT
ecj-10810	356	7	lapinsky	lapinsky	ADJ
ecj-10810	356	8	se	se	PROPN
ecj-10810	356	9	,	,	PUNCT
ecj-10810	356	10	et	et	PROPN
ecj-10810	356	11	al	al	PROPN
ecj-10810	356	12	.	.	PROPN
ecj-10810	357	1	for	for	ADP
ecj-10810	357	2	the	the	DET
ecj-10810	357	3	cooperative	cooperative	ADJ
ecj-10810	357	4	antimicrobial	antimicrobial	ADJ
ecj-10810	357	5	therapy	therapy	NOUN
ecj-10810	357	6	of	of	ADP
ecj-10810	357	7	septic	septic	ADJ
ecj-10810	357	8	shock	shock	NOUN
ecj-10810	357	9	database	database	NOUN
ecj-10810	357	10	research	research	NOUN
ecj-10810	357	11	group	group	NOUN
ecj-10810	357	12	.	.	PUNCT
ecj-10810	358	1	interaction	interaction	NOUN
ecj-10810	358	2	between	between	ADP
ecj-10810	358	3	fluids	fluid	NOUN
ecj-10810	358	4	and	and	CCONJ
ecj-10810	358	5	vasoactive	vasoactive	ADJ
ecj-10810	358	6	agents	agent	NOUN
ecj-10810	358	7	on	on	ADP
ecj-10810	358	8	mortality	mortality	NOUN
ecj-10810	358	9	in	in	ADP
ecj-10810	358	10	septic	septic	ADJ
ecj-10810	358	11	shock	shock	NOUN
ecj-10810	358	12	:	:	PUNCT
ecj-10810	358	13	a	a	DET
ecj-10810	358	14	multicenter	multicenter	NOUN
ecj-10810	358	15	,	,	PUNCT
ecj-10810	358	16	observational	observational	ADJ
ecj-10810	358	17	study	study	NOUN
ecj-10810	358	18	.	.	PUNCT
ecj-10810	359	1	crit	crit	PROPN
ecj-10810	359	2	care	care	PROPN
ecj-10810	359	3	med	med	PROPN
ecj-10810	359	4	2014;42:2158	2014;42:2158	NUM
ecj-10810	359	5	-	-	SYM
ecj-10810	359	6	68	68	NUM
ecj-10810	359	7	.	.	PUNCT
ecj-10810	360	1	71	71	NUM
ecj-10810	360	2	.	.	PUNCT
ecj-10810	361	1	takala	takala	PROPN
ecj-10810	361	2	j.	j.	PROPN
ecj-10810	361	3	should	should	AUX
ecj-10810	361	4	we	we	PRON
ecj-10810	361	5	target	target	VERB
ecj-10810	361	6	blood	blood	NOUN
ecj-10810	361	7	pressure	pressure	NOUN
ecj-10810	361	8	in	in	ADP
ecj-10810	361	9	sepsis	sepsis	NOUN
ecj-10810	361	10	?	?	PUNCT
ecj-10810	362	1	crit	crit	PROPN
ecj-10810	362	2	care	care	NOUN
ecj-10810	362	3	med	med	ADJ
ecj-10810	362	4	2010;38	2010;38	NUM
ecj-10810	362	5	:	:	PUNCT
ecj-10810	362	6	s613	s613	PROPN
ecj-10810	362	7	–	–	PUNCT
ecj-10810	362	8	s619	s619	NUM
ecj-10810	362	9	.	.	PUNCT
ecj-10810	363	1	72	72	NUM
ecj-10810	363	2	.	.	PUNCT
ecj-10810	364	1	martin	martin	PROPN
ecj-10810	364	2	c	c	PROPN
ecj-10810	364	3	,	,	PUNCT
ecj-10810	364	4	medam	medam	NOUN
ecj-10810	364	5	s	s	PROPN
ecj-10810	364	6	,	,	PUNCT
ecj-10810	364	7	antonini	antonini	PROPN
ecj-10810	364	8	f	f	PROPN
ecj-10810	364	9	,	,	PUNCT
ecj-10810	364	10	et	et	PROPN
ecj-10810	364	11	al	al	PROPN
ecj-10810	364	12	.	.	PUNCT
ecj-10810	364	13	norepinephrine	norepinephrine	NOUN
ecj-10810	364	14	:	:	PUNCT
ecj-10810	364	15	not	not	PART
ecj-10810	364	16	too	too	ADV
ecj-10810	364	17	much	much	ADJ
ecj-10810	364	18	,	,	PUNCT
ecj-10810	364	19	too	too	ADV
ecj-10810	364	20	long	long	ADV
ecj-10810	364	21	.	.	PUNCT
ecj-10810	365	1	shock	shock	NOUN
ecj-10810	365	2	2015;44:305–9	2015;44:305–9	NUM
ecj-10810	365	3	.	.	PUNCT
ecj-10810	366	1	73	73	NUM
ecj-10810	366	2	.	.	PUNCT
ecj-10810	367	1	stolk	stolk	PROPN
ecj-10810	367	2	rf	rf	PROPN
ecj-10810	367	3	,	,	PUNCT
ecj-10810	367	4	van	van	PROPN
ecj-10810	367	5	der	der	PROPN
ecj-10810	367	6	poll	poll	PROPN
ecj-10810	367	7	t	t	PROPN
ecj-10810	367	8	,	,	PUNCT
ecj-10810	367	9	angus	angus	PROPN
ecj-10810	367	10	dc	dc	PROPN
ecj-10810	367	11	,	,	PUNCT
ecj-10810	367	12	et	et	PROPN
ecj-10810	367	13	al	al	PROPN
ecj-10810	367	14	.	.	PUNCT
ecj-10810	368	1	potentially	potentially	ADV
ecj-10810	368	2	inadvertent	inadvertent	ADJ
ecj-10810	368	3	immunomodulation	immunomodulation	NOUN
ecj-10810	368	4	:	:	PUNCT
ecj-10810	368	5	norepinephrine	norepinephrine	NOUN
ecj-10810	368	6	use	use	NOUN
ecj-10810	368	7	in	in	ADP
ecj-10810	368	8	sepsis	sepsis	NOUN
ecj-10810	368	9	.	.	PUNCT
ecj-10810	369	1	am	be	AUX
ecj-10810	369	2	j	j	PROPN
ecj-10810	369	3	respir	respir	NOUN
ecj-10810	369	4	crit	crit	PROPN
ecj-10810	369	5	care	care	NOUN
ecj-10810	369	6	med	med	PROPN
ecj-10810	369	7	2016;194:550–8	2016;194:550–8	NOUN
ecj-10810	369	8	.	.	PUNCT
ecj-10810	370	1	74	74	NUM
ecj-10810	370	2	.	.	X
ecj-10810	371	1	morelli	morelli	PROPN
ecj-10810	371	2	a	a	PROPN
ecj-10810	371	3	,	,	PUNCT
ecj-10810	371	4	ertmer	ertmer	PROPN
ecj-10810	371	5	c	c	PROPN
ecj-10810	371	6	,	,	PUNCT
ecj-10810	371	7	westphal	westphal	PROPN
ecj-10810	371	8	m	m	PROPN
ecj-10810	371	9	,	,	PUNCT
ecj-10810	371	10	et	et	PROPN
ecj-10810	371	11	al	al	PROPN
ecj-10810	371	12	.	.	PROPN
ecj-10810	371	13	effect	effect	NOUN
ecj-10810	371	14	of	of	ADP
ecj-10810	371	15	heart	heart	NOUN
ecj-10810	371	16	rate	rate	NOUN
ecj-10810	371	17	control	control	NOUN
ecj-10810	371	18	with	with	ADP
ecj-10810	371	19	esmolol	esmolol	PROPN
ecj-10810	371	20	on	on	ADP
ecj-10810	371	21	hemodynamic	hemodynamic	ADJ
ecj-10810	371	22	and	and	CCONJ
ecj-10810	371	23	clinical	clinical	ADJ
ecj-10810	371	24	outcomes	outcome	NOUN
ecj-10810	371	25	in	in	ADP
ecj-10810	371	26	patients	patient	NOUN
ecj-10810	371	27	with	with	ADP
ecj-10810	371	28	septic	septic	ADJ
ecj-10810	371	29	shock	shock	NOUN
ecj-10810	371	30	:	:	PUNCT
ecj-10810	371	31	a	a	DET
ecj-10810	371	32	randomized	randomized	ADJ
ecj-10810	371	33	clinical	clinical	ADJ
ecj-10810	371	34	trial	trial	NOUN
ecj-10810	371	35	.	.	PUNCT
ecj-10810	372	1	jama	jama	PROPN
ecj-10810	372	2	2013;310:1683–91	2013;310:1683–91	NUM
ecj-10810	372	3	.	.	PUNCT
ecj-10810	373	1	75	75	NUM
ecj-10810	373	2	.	.	PUNCT
ecj-10810	374	1	kopczynska	kopczynska	PROPN
ecj-10810	374	2	m	m	PROPN
ecj-10810	374	3	,	,	PUNCT
ecj-10810	374	4	sharif	sharif	PROPN
ecj-10810	374	5	b	b	PROPN
ecj-10810	374	6	,	,	PUNCT
ecj-10810	374	7	cleaver	cleaver	NOUN
ecj-10810	374	8	s	s	PROPN
ecj-10810	374	9	,	,	PUNCT
ecj-10810	374	10	et	et	PROPN
ecj-10810	374	11	al	al	PROPN
ecj-10810	374	12	.	.	PROPN
ecj-10810	374	13	sepsis	sepsis	NOUN
ecj-10810	374	14	-	-	PUNCT
ecj-10810	374	15	related	relate	VERB
ecj-10810	374	16	deaths	death	NOUN
ecj-10810	374	17	in	in	ADP
ecj-10810	374	18	the	the	DET
ecj-10810	374	19	at	at	ADP
ecj-10810	374	20	-	-	PUNCT
ecj-10810	374	21	risk	risk	NOUN
ecj-10810	374	22	population	population	NOUN
ecj-10810	374	23	on	on	ADP
ecj-10810	374	24	the	the	DET
ecj-10810	374	25	wards	ward	NOUN
ecj-10810	374	26	:	:	PUNCT
ecj-10810	374	27	attributable	attributable	ADJ
ecj-10810	374	28	fraction	fraction	NOUN
ecj-10810	374	29	of	of	ADP
ecj-10810	374	30	mortality	mortality	NOUN
ecj-10810	374	31	in	in	ADP
ecj-10810	374	32	a	a	DET
ecj-10810	374	33	large	large	ADJ
ecj-10810	374	34	point	point	NOUN
ecj-10810	374	35	-	-	PUNCT
ecj-10810	374	36	prevalence	prevalence	NOUN
ecj-10810	374	37	study	study	NOUN
ecj-10810	374	38	.	.	PUNCT
ecj-10810	375	1	bmc	bmc	ADJ
ecj-10810	375	2	res	re	NOUN
ecj-10810	375	3	notes	note	NOUN
ecj-10810	375	4	2018;11:720	2018;11:720	PRON
ecj-10810	375	5	.	.	PROPN
ecj-10810	375	6	76	76	NUM
ecj-10810	375	7	.	.	PUNCT
ecj-10810	376	1	rhee	rhee	PROPN
ecj-10810	376	2	c	c	PROPN
ecj-10810	376	3	,	,	PUNCT
ecj-10810	376	4	jones	jones	PROPN
ecj-10810	376	5	tm	tm	PROPN
ecj-10810	376	6	,	,	PUNCT
ecj-10810	376	7	hamad	hamad	PROPN
ecj-10810	376	8	y	y	PROPN
ecj-10810	376	9	,	,	PUNCT
ecj-10810	376	10	et	et	PROPN
ecj-10810	376	11	al	al	PROPN
ecj-10810	376	12	.	.	PUNCT
ecj-10810	376	13	prevalence	prevalence	NOUN
ecj-10810	376	14	,	,	PUNCT
ecj-10810	376	15	underlying	underlie	VERB
ecj-10810	376	16	causes	cause	NOUN
ecj-10810	376	17	,	,	PUNCT
ecj-10810	376	18	and	and	CCONJ
ecj-10810	376	19	preventability	preventability	NOUN
ecj-10810	376	20	of	of	ADP
ecj-10810	376	21	sepsis	sepsis	NOUN
ecj-10810	376	22	-	-	PUNCT
ecj-10810	376	23	associated	associate	VERB
ecj-10810	376	24	mortality	mortality	NOUN
ecj-10810	376	25	in	in	ADP
ecj-10810	376	26	us	us	PROPN
ecj-10810	376	27	acute	acute	PROPN
ecj-10810	376	28	care	care	NOUN
ecj-10810	376	29	hospitals	hospital	NOUN
ecj-10810	376	30	.	.	PUNCT
ecj-10810	377	1	jama	jama	PROPN
ecj-10810	377	2	netw	netw	PROPN
ecj-10810	377	3	open	open	ADJ
ecj-10810	377	4	2019;2	2019;2	NUM
ecj-10810	377	5	:	:	PUNCT
ecj-10810	377	6	e187571	e187571	NOUN
ecj-10810	377	7	.	.	PUNCT
ecj-10810	378	1	77	77	NUM
ecj-10810	378	2	.	.	PUNCT
ecj-10810	379	1	loubani	loubani	PROPN
ecj-10810	379	2	om	om	PROPN
ecj-10810	379	3	,	,	PUNCT
ecj-10810	379	4	green	green	ADJ
ecj-10810	379	5	rs	rs	NOUN
ecj-10810	379	6	.	.	PUNCT
ecj-10810	380	1	a	a	DET
ecj-10810	380	2	systematic	systematic	ADJ
ecj-10810	380	3	review	review	NOUN
ecj-10810	380	4	of	of	ADP
ecj-10810	380	5	extravasation	extravasation	NOUN
ecj-10810	380	6	and	and	CCONJ
ecj-10810	380	7	local	local	ADJ
ecj-10810	380	8	tissue	tissue	NOUN
ecj-10810	380	9	injury	injury	NOUN
ecj-10810	380	10	from	from	ADP
ecj-10810	380	11	administration	administration	NOUN
ecj-10810	380	12	of	of	ADP
ecj-10810	380	13	vasopressors	vasopressor	NOUN
ecj-10810	380	14	through	through	ADP
ecj-10810	380	15	peripheral	peripheral	ADJ
ecj-10810	380	16	intravenous	intravenous	ADJ
ecj-10810	380	17	catheters	catheter	NOUN
ecj-10810	380	18	and	and	CCONJ
ecj-10810	380	19	central	central	ADJ
ecj-10810	380	20	venous	venous	ADJ
ecj-10810	380	21	catheters	catheter	NOUN
ecj-10810	380	22	.	.	PUNCT
ecj-10810	381	1	j	j	PROPN
ecj-10810	381	2	crit	crit	PROPN
ecj-10810	381	3	care	care	PROPN
ecj-10810	381	4	2015;30:653.e9–653.e17	2015;30:653.e9–653.e17	PROPN
ecj-10810	381	5	78	78	NUM
ecj-10810	381	6	.	.	PUNCT
ecj-10810	382	1	corradi	corradi	PROPN
ecj-10810	382	2	f	f	PROPN
ecj-10810	382	3	,	,	PUNCT
ecj-10810	382	4	via	via	ADP
ecj-10810	382	5	g	g	NOUN
ecj-10810	382	6	,	,	PUNCT
ecj-10810	383	1	tavazzi	tavazzi	ADJ
ecj-10810	383	2	g.	g.	PROPN
ecj-10810	384	1	what	what	PRON
ecj-10810	384	2	's	be	AUX
ecj-10810	384	3	new	new	ADJ
ecj-10810	384	4	in	in	ADP
ecj-10810	384	5	ultrasound	ultrasound	NOUN
ecj-10810	384	6	-	-	PUNCT
ecj-10810	384	7	based	base	VERB
ecj-10810	384	8	assessment	assessment	NOUN
ecj-10810	384	9	of	of	ADP
ecj-10810	384	10	organ	organ	NOUN
ecj-10810	384	11	perfusion	perfusion	NOUN
ecj-10810	384	12	in	in	ADP
ecj-10810	384	13	the	the	DET
ecj-10810	384	14	critically	critically	ADV
ecj-10810	384	15	ill	ill	ADJ
ecj-10810	384	16	:	:	PUNCT
ecj-10810	384	17	expanding	expand	VERB
ecj-10810	384	18	the	the	DET
ecj-10810	384	19	bedside	bedside	NOUN
ecj-10810	384	20	clinical	clinical	ADJ
ecj-10810	384	21	monitoring	monitoring	NOUN
ecj-10810	384	22	window	window	NOUN
ecj-10810	384	23	for	for	ADP
ecj-10810	384	24	hypoperfusion	hypoperfusion	NOUN
ecj-10810	384	25	in	in	ADP
ecj-10810	384	26	shock	shock	NOUN
ecj-10810	384	27	.	.	PUNCT
ecj-10810	385	1	intensive	intensive	ADJ
ecj-10810	385	2	care	care	NOUN
ecj-10810	385	3	med	med	PROPN
ecj-10810	385	4	2020;46:775	2020;46:775	NOUN
ecj-10810	385	5	-	-	SYM
ecj-10810	385	6	9	9	NUM
ecj-10810	385	7	.	.	PUNCT
ecj-10810	386	1	review	review	NOUN
ecj-10810	387	1	[	[	X
ecj-10810	387	2	page	page	NOUN
ecj-10810	387	3	16	16	NUM
ecj-10810	387	4	]	]	PUNCT
ecj-10810	388	1	[	[	X
ecj-10810	388	2	emergency	emergency	NOUN
ecj-10810	388	3	care	care	NOUN
ecj-10810	388	4	journal	journal	NOUN
ecj-10810	388	5	2023	2023	NUM
ecj-10810	388	6	;	;	PUNCT
ecj-10810	388	7	19:10810	19:10810	X
ecj-10810	388	8	]	]	X
ecj-10810	388	9	non	non	ADJ
ecj-10810	388	10	-co	-co	PROPN
ecj-10810	388	11	mmerc	mmerc	PROPN
ecj-10810	388	12	ial	ial	PROPN
ecj-10810	388	13	us	us	PROPN
ecj-10810	388	14	e	e	NOUN
ecj-10810	388	15	o	o	NOUN
ecj-10810	388	16	nly	nly	ADV