id	sid	tid	token	lemma	pos
ecj-12166	1	1	hrev_master	hrev_master	NOUN
ecj-12166	2	1	[	[	X
ecj-12166	2	2	page	page	NOUN
ecj-12166	2	3	30	30	NUM
ecj-12166	2	4	]	]	PUNCT
ecj-12166	3	1	[	[	X
ecj-12166	3	2	emergency	emergency	NOUN
ecj-12166	3	3	care	care	NOUN
ecj-12166	3	4	journal	journal	PROPN
ecj-12166	3	5	2024	2024	NUM
ecj-12166	3	6	;	;	PUNCT
ecj-12166	3	7	20:12166	20:12166	X
ecj-12166	3	8	]	]	X
ecj-12166	3	9	emergency	emergency	NOUN
ecj-12166	3	10	care	care	NOUN
ecj-12166	3	11	journal	journal	PROPN
ecj-12166	3	12	2024	2024	NUM
ecj-12166	3	13	volume	volume	NOUN
ecj-12166	3	14	20:12166	20:12166	NUM
ecj-12166	4	1	abstract	abstract	ADJ
ecj-12166	4	2	ketamine	ketamine	PROPN
ecj-12166	4	3	is	be	AUX
ecj-12166	4	4	a	a	DET
ecj-12166	4	5	fast	fast	ADV
ecj-12166	4	6	-	-	PUNCT
ecj-12166	4	7	acting	act	VERB
ecj-12166	4	8	n	n	CCONJ
ecj-12166	4	9	-	-	PUNCT
ecj-12166	4	10	methyl	methyl	NOUN
ecj-12166	4	11	-	-	PUNCT
ecj-12166	4	12	d	d	NOUN
ecj-12166	4	13	-	-	NOUN
ecj-12166	4	14	aspartate	aspartate	ADJ
ecj-12166	4	15	(	(	PUNCT
ecj-12166	4	16	nmda	nmda	ADJ
ecj-12166	4	17	)	)	PUNCT
ecj-12166	4	18	receptor	receptor	NOUN
ecj-12166	4	19	antagonist	antagonist	NOUN
ecj-12166	4	20	that	that	PRON
ecj-12166	4	21	can	can	AUX
ecj-12166	4	22	be	be	AUX
ecj-12166	4	23	used	use	VERB
ecj-12166	4	24	in	in	ADP
ecj-12166	4	25	a	a	DET
ecj-12166	4	26	range	range	NOUN
ecj-12166	4	27	of	of	ADP
ecj-12166	4	28	clinical	clinical	ADJ
ecj-12166	4	29	scenarios	scenario	NOUN
ecj-12166	4	30	in	in	ADP
ecj-12166	4	31	the	the	DET
ecj-12166	4	32	pre	pre	ADJ
ecj-12166	4	33	-	-	ADJ
ecj-12166	4	34	hospital	hospital	ADJ
ecj-12166	4	35	setting	setting	NOUN
ecj-12166	4	36	and	and	CCONJ
ecj-12166	4	37	emergency	emergency	NOUN
ecj-12166	4	38	department	department	NOUN
ecj-12166	4	39	(	(	PUNCT
ecj-12166	4	40	ed	ed	NOUN
ecj-12166	4	41	)	)	PUNCT
ecj-12166	4	42	.	.	PUNCT
ecj-12166	5	1	when	when	SCONJ
ecj-12166	5	2	compared	compare	VERB
ecj-12166	5	3	with	with	ADP
ecj-12166	5	4	other	other	ADJ
ecj-12166	5	5	anesthetic	anesthetic	ADJ
ecj-12166	5	6	agents	agent	NOUN
ecj-12166	5	7	,	,	PUNCT
ecj-12166	5	8	ketamine	ketamine	PROPN
ecj-12166	5	9	has	have	VERB
ecj-12166	5	10	many	many	ADJ
ecj-12166	5	11	unique	unique	ADJ
ecj-12166	5	12	properties	property	NOUN
ecj-12166	5	13	,	,	PUNCT
ecj-12166	5	14	such	such	ADJ
ecj-12166	5	15	as	as	ADP
ecj-12166	5	16	the	the	DET
ecj-12166	5	17	ability	ability	NOUN
ecj-12166	5	18	to	to	PART
ecj-12166	5	19	produce	produce	VERB
ecj-12166	5	20	dose	dose	NOUN
ecj-12166	5	21	-	-	PUNCT
ecj-12166	5	22	dependent	dependent	ADJ
ecj-12166	5	23	analgesic	analgesic	ADJ
ecj-12166	5	24	and	and	CCONJ
ecj-12166	5	25	anesthetic	anesthetic	ADJ
ecj-12166	5	26	effects	effect	NOUN
ecj-12166	5	27	with	with	ADP
ecj-12166	5	28	a	a	DET
ecj-12166	5	29	wide	wide	ADJ
ecj-12166	5	30	margin	margin	NOUN
ecj-12166	5	31	of	of	ADP
ecj-12166	5	32	safety	safety	NOUN
ecj-12166	5	33	.	.	PUNCT
ecj-12166	6	1	ketamine	ketamine	PROPN
ecj-12166	6	2	may	may	AUX
ecj-12166	6	3	be	be	AUX
ecj-12166	6	4	used	use	VERB
ecj-12166	6	5	in	in	ADP
ecj-12166	6	6	the	the	DET
ecj-12166	6	7	ed	ed	NOUN
ecj-12166	6	8	for	for	ADP
ecj-12166	6	9	sedation	sedation	NOUN
ecj-12166	6	10	,	,	PUNCT
ecj-12166	6	11	pain	pain	NOUN
ecj-12166	6	12	management	management	NOUN
ecj-12166	6	13	,	,	PUNCT
ecj-12166	6	14	and	and	CCONJ
ecj-12166	6	15	acute	acute	ADJ
ecj-12166	6	16	agitation	agitation	NOUN
ecj-12166	6	17	treatment	treatment	NOUN
ecj-12166	6	18	in	in	ADP
ecj-12166	6	19	the	the	DET
ecj-12166	6	20	cases	case	NOUN
ecj-12166	6	21	of	of	ADP
ecj-12166	6	22	benzodiazepine	benzodiazepine	NOUN
ecj-12166	6	23	(	(	PUNCT
ecj-12166	6	24	bdz)-resistant	bdz)-resistant	ADJ
ecj-12166	6	25	alcohol	alcohol	NOUN
ecj-12166	6	26	withdrawal	withdrawal	NOUN
ecj-12166	6	27	syndrome	syndrome	PROPN
ecj-12166	6	28	(	(	PUNCT
ecj-12166	6	29	aws	aws	NOUN
ecj-12166	6	30	)	)	PUNCT
ecj-12166	6	31	and	and	CCONJ
ecj-12166	6	32	substance	substance	NOUN
ecj-12166	6	33	use	use	NOUN
ecj-12166	6	34	disorder	disorder	NOUN
ecj-12166	6	35	.	.	PUNCT
ecj-12166	7	1	to	to	PART
ecj-12166	7	2	highlight	highlight	VERB
ecj-12166	7	3	the	the	DET
ecj-12166	7	4	efficacy	efficacy	NOUN
ecj-12166	7	5	and	and	CCONJ
ecj-12166	7	6	safety	safety	NOUN
ecj-12166	7	7	of	of	ADP
ecj-12166	7	8	ketamine	ketamine	PROPN
ecj-12166	7	9	,	,	PUNCT
ecj-12166	7	10	we	we	PRON
ecj-12166	7	11	reviewed	review	VERB
ecj-12166	7	12	the	the	DET
ecj-12166	7	13	literature	literature	NOUN
ecj-12166	7	14	,	,	PUNCT
ecj-12166	7	15	starting	start	VERB
ecj-12166	7	16	with	with	ADP
ecj-12166	7	17	a	a	DET
ecj-12166	7	18	description	description	NOUN
ecj-12166	7	19	of	of	ADP
ecj-12166	7	20	four	four	NUM
ecj-12166	7	21	different	different	ADJ
ecj-12166	7	22	cases	case	NOUN
ecj-12166	7	23	of	of	ADP
ecj-12166	7	24	patients	patient	NOUN
ecj-12166	7	25	who	who	PRON
ecj-12166	7	26	presented	present	VERB
ecj-12166	7	27	to	to	ADP
ecj-12166	7	28	our	our	PRON
ecj-12166	7	29	ed	ed	NOUN
ecj-12166	7	30	and	and	CCONJ
ecj-12166	7	31	were	be	AUX
ecj-12166	7	32	treated	treat	VERB
ecj-12166	7	33	with	with	ADP
ecj-12166	7	34	ketamine	ketamine	PROPN
ecj-12166	7	35	.	.	PUNCT
ecj-12166	8	1	case	case	NOUN
ecj-12166	8	2	reports	report	VERB
ecj-12166	8	3	we	we	PRON
ecj-12166	8	4	briefly	briefly	ADV
ecj-12166	8	5	present	present	VERB
ecj-12166	8	6	four	four	NUM
ecj-12166	8	7	cases	case	NOUN
ecj-12166	8	8	of	of	ADP
ecj-12166	8	9	patients	patient	NOUN
ecj-12166	8	10	who	who	PRON
ecj-12166	8	11	were	be	AUX
ecj-12166	8	12	admitted	admit	VERB
ecj-12166	8	13	to	to	ADP
ecj-12166	8	14	the	the	DET
ecj-12166	8	15	ed	ed	NOUN
ecj-12166	8	16	of	of	ADP
ecj-12166	8	17	guglielmo	guglielmo	PROPN
ecj-12166	8	18	da	da	PROPN
ecj-12166	8	19	saliceto	saliceto	PROPN
ecj-12166	8	20	hospital	hospital	NOUN
ecj-12166	8	21	,	,	PUNCT
ecj-12166	8	22	piacenza	piacenza	PROPN
ecj-12166	8	23	,	,	PUNCT
ecj-12166	8	24	italy	italy	PROPN
ecj-12166	8	25	,	,	PUNCT
ecj-12166	8	26	and	and	CCONJ
ecj-12166	8	27	treated	treat	VERB
ecj-12166	8	28	with	with	ADP
ecj-12166	8	29	ketamine	ketamine	PROPN
ecj-12166	8	30	for	for	ADP
ecj-12166	8	31	four	four	NUM
ecj-12166	8	32	different	different	ADJ
ecj-12166	8	33	causes	cause	NOUN
ecj-12166	8	34	.	.	PUNCT
ecj-12166	9	1	case	case	NOUN
ecj-12166	9	2	#	#	SYM
ecj-12166	9	3	1	1	NUM
ecj-12166	9	4	as	as	ADP
ecj-12166	9	5	a	a	DET
ecj-12166	9	6	result	result	NOUN
ecj-12166	9	7	of	of	ADP
ecj-12166	9	8	acute	acute	ADJ
ecj-12166	9	9	alcohol	alcohol	NOUN
ecj-12166	9	10	withdrawal	withdrawal	NOUN
ecj-12166	9	11	syndrome	syndrome	PROPN
ecj-12166	9	12	(	(	PUNCT
ecj-12166	9	13	aws	aws	PROPN
ecj-12166	9	14	)	)	PUNCT
ecj-12166	9	15	,	,	PUNCT
ecj-12166	9	16	a	a	DET
ecj-12166	9	17	48year	48year	NUM
ecj-12166	9	18	-	-	PUNCT
ecj-12166	9	19	old	old	ADJ
ecj-12166	9	20	man	man	NOUN
ecj-12166	9	21	developed	develop	VERB
ecj-12166	9	22	delirium	delirium	NOUN
ecj-12166	9	23	tremens	tremen	NOUN
ecj-12166	9	24	with	with	ADP
ecj-12166	9	25	tachycardia	tachycardia	NOUN
ecj-12166	9	26	,	,	PUNCT
ecj-12166	9	27	hypertension	hypertension	NOUN
ecj-12166	9	28	,	,	PUNCT
ecj-12166	9	29	diaphoresis	diaphoresis	NOUN
ecj-12166	9	30	,	,	PUNCT
ecj-12166	9	31	agitation	agitation	NOUN
ecj-12166	9	32	,	,	PUNCT
ecj-12166	9	33	and	and	CCONJ
ecj-12166	9	34	hallucinations	hallucination	NOUN
ecj-12166	9	35	while	while	SCONJ
ecj-12166	9	36	recovering	recover	VERB
ecj-12166	9	37	in	in	ADP
ecj-12166	9	38	our	our	PRON
ecj-12166	9	39	observational	observational	ADJ
ecj-12166	9	40	unit	unit	NOUN
ecj-12166	9	41	.	.	PUNCT
ecj-12166	10	1	he	he	PRON
ecj-12166	10	2	was	be	AUX
ecj-12166	10	3	immediately	immediately	ADV
ecj-12166	10	4	treated	treat	VERB
ecj-12166	10	5	with	with	ADP
ecj-12166	10	6	benzodiazepines	benzodiazepine	NOUN
ecj-12166	10	7	,	,	PUNCT
ecj-12166	10	8	using	use	VERB
ecj-12166	10	9	delorazepam	delorazepam	NOUN
ecj-12166	10	10	5	5	NUM
ecj-12166	10	11	mg	mg	NOUN
ecj-12166	10	12	intravenous	intravenous	ADJ
ecj-12166	10	13	(	(	PUNCT
ecj-12166	10	14	iv	iv	NUM
ecj-12166	10	15	)	)	PUNCT
ecj-12166	10	16	and	and	CCONJ
ecj-12166	10	17	midazolam	midazolam	PROPN
ecj-12166	10	18	5	5	NUM
ecj-12166	10	19	mg	mg	PROPN
ecj-12166	10	20	bolus	bolus	PROPN
ecj-12166	10	21	iv	iv	PROPN
ecj-12166	10	22	,	,	PUNCT
ecj-12166	10	23	followed	follow	VERB
ecj-12166	10	24	by	by	ADP
ecj-12166	10	25	a	a	DET
ecj-12166	10	26	continuous	continuous	ADJ
ecj-12166	10	27	infusion	infusion	NOUN
ecj-12166	10	28	of	of	ADP
ecj-12166	10	29	midazolam	midazolam	PROPN
ecj-12166	10	30	without	without	ADP
ecj-12166	10	31	benefits	benefit	NOUN
ecj-12166	10	32	.	.	PUNCT
ecj-12166	11	1	a	a	DET
ecj-12166	11	2	diagnosis	diagnosis	NOUN
ecj-12166	11	3	of	of	ADP
ecj-12166	11	4	benzodiazepine	benzodiazepine	NOUN
ecj-12166	11	5	-	-	PUNCT
ecj-12166	11	6	resistant	resistant	ADJ
ecj-12166	11	7	aws	aw	NOUN
ecj-12166	11	8	was	be	AUX
ecj-12166	11	9	correspondence	correspondence	NOUN
ecj-12166	11	10	:	:	PUNCT
ecj-12166	11	11	andrea	andrea	PROPN
ecj-12166	11	12	vercelli	vercelli	PROPN
ecj-12166	11	13	,	,	PUNCT
ecj-12166	11	14	emergency	emergency	NOUN
ecj-12166	11	15	department	department	NOUN
ecj-12166	11	16	,	,	PUNCT
ecj-12166	11	17	guglielmo	guglielmo	PROPN
ecj-12166	11	18	da	da	PROPN
ecj-12166	11	19	saliceto	saliceto	PROPN
ecj-12166	11	20	hospital	hospital	NOUN
ecj-12166	11	21	,	,	PUNCT
ecj-12166	11	22	via	via	ADP
ecj-12166	11	23	taverna	taverna	NOUN
ecj-12166	11	24	49	49	NUM
ecj-12166	11	25	,	,	PUNCT
ecj-12166	11	26	29121	29121	NUM
ecj-12166	11	27	,	,	PUNCT
ecj-12166	11	28	piacenza	piacenza	PROPN
ecj-12166	11	29	,	,	PUNCT
ecj-12166	11	30	italy	italy	PROPN
ecj-12166	11	31	.	.	PUNCT
ecj-12166	12	1	tel	tel	PROPN
ecj-12166	12	2	.	.	PUNCT
ecj-12166	12	3	:	:	PUNCT
ecj-12166	13	1	+39.0523.303044	+39.0523.303044	X
ecj-12166	13	2	e	e	NOUN
ecj-12166	13	3	-	-	NOUN
ecj-12166	13	4	mail	mail	NOUN
ecj-12166	13	5	:	:	PUNCT
ecj-12166	13	6	a.vercelli@ausl.pc.it	a.vercelli@ausl.pc.it	DET
ecj-12166	13	7	key	key	ADJ
ecj-12166	13	8	words	word	NOUN
ecj-12166	13	9	:	:	PUNCT
ecj-12166	13	10	ketamine	ketamine	PROPN
ecj-12166	13	11	,	,	PUNCT
ecj-12166	13	12	pain	pain	NOUN
ecj-12166	13	13	management	management	NOUN
ecj-12166	13	14	,	,	PUNCT
ecj-12166	13	15	renal	renal	ADJ
ecj-12166	13	16	colic	colic	NOUN
ecj-12166	13	17	,	,	PUNCT
ecj-12166	13	18	alcohol	alcohol	NOUN
ecj-12166	13	19	withdrawal	withdrawal	NOUN
ecj-12166	13	20	,	,	PUNCT
ecj-12166	13	21	emergency	emergency	NOUN
ecj-12166	13	22	department	department	NOUN
ecj-12166	13	23	,	,	PUNCT
ecj-12166	13	24	emergency	emergency	NOUN
ecj-12166	13	25	medicine	medicine	NOUN
ecj-12166	13	26	.	.	PUNCT
ecj-12166	14	1	contributions	contribution	NOUN
ecj-12166	14	2	:	:	PUNCT
ecj-12166	14	3	ef	ef	PROPN
ecj-12166	14	4	and	and	CCONJ
ecj-12166	14	5	ep	ep	PROPN
ecj-12166	14	6	collected	collect	VERB
ecj-12166	14	7	details	detail	NOUN
ecj-12166	14	8	of	of	ADP
ecj-12166	14	9	the	the	DET
ecj-12166	14	10	case	case	NOUN
ecj-12166	14	11	and	and	CCONJ
ecj-12166	14	12	drafted	draft	VERB
ecj-12166	14	13	the	the	DET
ecj-12166	14	14	manuscript	manuscript	NOUN
ecj-12166	14	15	.	.	PUNCT
ecj-12166	15	1	ep	ep	PROPN
ecj-12166	15	2	,	,	PUNCT
ecj-12166	15	3	fb	fb	INTJ
ecj-12166	15	4	,	,	PUNCT
ecj-12166	15	5	ei	ei	NOUN
ecj-12166	15	6	,	,	PUNCT
ecj-12166	15	7	and	and	CCONJ
ecj-12166	15	8	db	db	AUX
ecj-12166	15	9	cared	care	VERB
ecj-12166	15	10	for	for	ADP
ecj-12166	15	11	the	the	DET
ecj-12166	15	12	patient	patient	NOUN
ecj-12166	15	13	.	.	PUNCT
ecj-12166	16	1	ar	ar	PROPN
ecj-12166	16	2	and	and	CCONJ
ecj-12166	16	3	av	av	PROPN
ecj-12166	16	4	critically	critically	ADV
ecj-12166	16	5	revised	revise	VERB
ecj-12166	16	6	the	the	DET
ecj-12166	16	7	manuscript	manuscript	NOUN
ecj-12166	16	8	.	.	PUNCT
ecj-12166	17	1	all	all	DET
ecj-12166	17	2	the	the	DET
ecj-12166	17	3	authors	author	NOUN
ecj-12166	17	4	approved	approve	VERB
ecj-12166	17	5	the	the	DET
ecj-12166	17	6	final	final	ADJ
ecj-12166	17	7	version	version	NOUN
ecj-12166	17	8	.	.	PUNCT
ecj-12166	18	1	conflicts	conflict	NOUN
ecj-12166	18	2	of	of	ADP
ecj-12166	18	3	interest	interest	NOUN
ecj-12166	18	4	:	:	PUNCT
ecj-12166	18	5	ep	ep	PROPN
ecj-12166	18	6	is	be	AUX
ecj-12166	18	7	a	a	DET
ecj-12166	18	8	member	member	NOUN
ecj-12166	18	9	of	of	ADP
ecj-12166	18	10	the	the	DET
ecj-12166	18	11	editorial	editorial	ADJ
ecj-12166	18	12	board	board	NOUN
ecj-12166	18	13	of	of	ADP
ecj-12166	18	14	emergency	emergency	NOUN
ecj-12166	18	15	care	care	NOUN
ecj-12166	18	16	journal	journal	NOUN
ecj-12166	18	17	.	.	PUNCT
ecj-12166	19	1	the	the	DET
ecj-12166	19	2	authors	author	NOUN
ecj-12166	19	3	declare	declare	VERB
ecj-12166	19	4	no	no	DET
ecj-12166	19	5	conflict	conflict	NOUN
ecj-12166	19	6	of	of	ADP
ecj-12166	19	7	interest	interest	NOUN
ecj-12166	19	8	.	.	PUNCT
ecj-12166	20	1	availability	availability	NOUN
ecj-12166	20	2	of	of	ADP
ecj-12166	20	3	data	datum	NOUN
ecj-12166	20	4	and	and	CCONJ
ecj-12166	20	5	materials	material	NOUN
ecj-12166	20	6	:	:	PUNCT
ecj-12166	20	7	all	all	DET
ecj-12166	20	8	data	datum	NOUN
ecj-12166	20	9	underlying	underlie	VERB
ecj-12166	20	10	the	the	DET
ecj-12166	20	11	findings	finding	NOUN
ecj-12166	20	12	are	be	AUX
ecj-12166	20	13	fully	fully	ADV
ecj-12166	20	14	available	available	ADJ
ecj-12166	20	15	upon	upon	SCONJ
ecj-12166	20	16	reasonable	reasonable	ADJ
ecj-12166	20	17	request	request	NOUN
ecj-12166	20	18	to	to	ADP
ecj-12166	20	19	andrea	andrea	PROPN
ecj-12166	20	20	vercelli	vercelli	PROPN
ecj-12166	20	21	,	,	PUNCT
ecj-12166	20	22	a.vercelli@ausl.pc.it	a.vercelli@ausl.pc.it	X
ecj-12166	20	23	.	.	PUNCT
ecj-12166	20	24	ethics	ethic	NOUN
ecj-12166	20	25	approval	approval	NOUN
ecj-12166	20	26	and	and	CCONJ
ecj-12166	20	27	consent	consent	NOUN
ecj-12166	20	28	to	to	PART
ecj-12166	20	29	participate	participate	VERB
ecj-12166	20	30	:	:	PUNCT
ecj-12166	20	31	as	as	SCONJ
ecj-12166	20	32	this	this	PRON
ecj-12166	20	33	was	be	AUX
ecj-12166	20	34	a	a	DET
ecj-12166	20	35	descriptive	descriptive	ADJ
ecj-12166	20	36	case	case	NOUN
ecj-12166	20	37	series	series	NOUN
ecj-12166	20	38	and	and	CCONJ
ecj-12166	20	39	a	a	DET
ecj-12166	20	40	literature	literature	NOUN
ecj-12166	20	41	review	review	NOUN
ecj-12166	20	42	data	datum	NOUN
ecj-12166	20	43	was	be	AUX
ecj-12166	20	44	collected	collect	VERB
ecj-12166	20	45	without	without	ADP
ecj-12166	20	46	patient	patient	ADJ
ecj-12166	20	47	identifiers	identifier	NOUN
ecj-12166	20	48	,	,	PUNCT
ecj-12166	20	49	ethics	ethic	NOUN
ecj-12166	20	50	approval	approval	NOUN
ecj-12166	20	51	was	be	AUX
ecj-12166	20	52	not	not	PART
ecj-12166	20	53	required	require	VERB
ecj-12166	20	54	under	under	ADP
ecj-12166	20	55	our	our	PRON
ecj-12166	20	56	hospital	hospital	NOUN
ecj-12166	20	57	’s	’s	PART
ecj-12166	20	58	institutional	institutional	PROPN
ecj-12166	20	59	review	review	NOUN
ecj-12166	20	60	board	board	NOUN
ecj-12166	20	61	guidelines	guideline	NOUN
ecj-12166	20	62	.	.	PUNCT
ecj-12166	21	1	received	receive	VERB
ecj-12166	21	2	:	:	PUNCT
ecj-12166	21	3	8	8	NUM
ecj-12166	21	4	decembeer	decembeer	NOUN
ecj-12166	21	5	2023	2023	NUM
ecj-12166	21	6	.	.	PUNCT
ecj-12166	22	1	accepted	accept	VERB
ecj-12166	22	2	:	:	PUNCT
ecj-12166	22	3	19	19	NUM
ecj-12166	22	4	january	january	NOUN
ecj-12166	22	5	2024	2024	NUM
ecj-12166	22	6	.	.	PUNCT
ecj-12166	23	1	early	early	ADJ
ecj-12166	23	2	view	view	NOUN
ecj-12166	23	3	:	:	PUNCT
ecj-12166	23	4	1	1	NUM
ecj-12166	23	5	february	february	NOUN
ecj-12166	23	6	2024	2024	NUM
ecj-12166	23	7	.	.	PUNCT
ecj-12166	24	1	this	this	DET
ecj-12166	24	2	work	work	NOUN
ecj-12166	24	3	is	be	AUX
ecj-12166	24	4	licensed	license	VERB
ecj-12166	24	5	under	under	ADP
ecj-12166	24	6	a	a	DET
ecj-12166	24	7	creative	creative	ADJ
ecj-12166	24	8	commons	common	NOUN
ecj-12166	24	9	attribution	attribution	NOUN
ecj-12166	24	10	4.0	4.0	NUM
ecj-12166	24	11	license	license	NOUN
ecj-12166	24	12	(	(	PUNCT
ecj-12166	24	13	by	by	ADP
ecj-12166	24	14	-	-	PUNCT
ecj-12166	24	15	nc	nc	PROPN
ecj-12166	24	16	4.0	4.0	NUM
ecj-12166	24	17	)	)	PUNCT
ecj-12166	24	18	.	.	PUNCT
ecj-12166	25	1	©	©	PROPN
ecj-12166	25	2	copyright	copyright	NOUN
ecj-12166	25	3	:	:	PUNCT
ecj-12166	25	4	the	the	DET
ecj-12166	25	5	author(s	author(s	PROPN
ecj-12166	25	6	)	)	PUNCT
ecj-12166	25	7	,	,	PUNCT
ecj-12166	25	8	2024	2024	NUM
ecj-12166	25	9	licensee	licensee	NOUN
ecj-12166	25	10	pagepress	pagepress	NOUN
ecj-12166	25	11	,	,	PUNCT
ecj-12166	25	12	italy	italy	PROPN
ecj-12166	25	13	emergency	emergency	PROPN
ecj-12166	25	14	care	care	PROPN
ecj-12166	25	15	journal	journal	PROPN
ecj-12166	25	16	2024	2024	NUM
ecj-12166	25	17	;	;	PUNCT
ecj-12166	25	18	20:12166	20:12166	NUM
ecj-12166	25	19	doi:10.4081	doi:10.4081	ADJ
ecj-12166	25	20	/	/	SYM
ecj-12166	25	21	ecj.2024.12166	ecj.2024.12166	PROPN
ecj-12166	25	22	publisher	publisher	NOUN
ecj-12166	25	23	's	's	PART
ecj-12166	25	24	note	note	NOUN
ecj-12166	25	25	:	:	PUNCT
ecj-12166	25	26	all	all	DET
ecj-12166	25	27	claims	claim	NOUN
ecj-12166	25	28	expressed	express	VERB
ecj-12166	25	29	in	in	ADP
ecj-12166	25	30	this	this	DET
ecj-12166	25	31	article	article	NOUN
ecj-12166	25	32	are	be	AUX
ecj-12166	25	33	solely	solely	ADV
ecj-12166	25	34	those	those	PRON
ecj-12166	25	35	of	of	ADP
ecj-12166	25	36	the	the	DET
ecj-12166	25	37	authors	author	NOUN
ecj-12166	25	38	and	and	CCONJ
ecj-12166	25	39	do	do	AUX
ecj-12166	25	40	not	not	PART
ecj-12166	25	41	necessarily	necessarily	ADV
ecj-12166	25	42	represent	represent	VERB
ecj-12166	25	43	those	those	PRON
ecj-12166	25	44	of	of	ADP
ecj-12166	25	45	their	their	PRON
ecj-12166	25	46	affiliated	affiliated	ADJ
ecj-12166	25	47	organizations	organization	NOUN
ecj-12166	25	48	,	,	PUNCT
ecj-12166	25	49	or	or	CCONJ
ecj-12166	25	50	those	those	PRON
ecj-12166	25	51	of	of	ADP
ecj-12166	25	52	the	the	DET
ecj-12166	25	53	publisher	publisher	NOUN
ecj-12166	25	54	,	,	PUNCT
ecj-12166	25	55	the	the	DET
ecj-12166	25	56	editors	editor	NOUN
ecj-12166	25	57	and	and	CCONJ
ecj-12166	25	58	the	the	DET
ecj-12166	25	59	reviewers	reviewer	NOUN
ecj-12166	25	60	.	.	PUNCT
ecj-12166	26	1	any	any	DET
ecj-12166	26	2	product	product	NOUN
ecj-12166	26	3	that	that	PRON
ecj-12166	26	4	may	may	AUX
ecj-12166	26	5	be	be	AUX
ecj-12166	26	6	evaluated	evaluate	VERB
ecj-12166	26	7	in	in	ADP
ecj-12166	26	8	this	this	DET
ecj-12166	26	9	article	article	NOUN
ecj-12166	26	10	or	or	CCONJ
ecj-12166	26	11	claim	claim	NOUN
ecj-12166	26	12	that	that	PRON
ecj-12166	26	13	may	may	AUX
ecj-12166	26	14	be	be	AUX
ecj-12166	26	15	made	make	VERB
ecj-12166	26	16	by	by	ADP
ecj-12166	26	17	its	its	PRON
ecj-12166	26	18	manufacturer	manufacturer	NOUN
ecj-12166	26	19	is	be	AUX
ecj-12166	26	20	not	not	PART
ecj-12166	26	21	guaranteed	guarantee	VERB
ecj-12166	26	22	or	or	CCONJ
ecj-12166	26	23	endorsed	endorse	VERB
ecj-12166	26	24	by	by	ADP
ecj-12166	26	25	the	the	DET
ecj-12166	26	26	publisher	publisher	NOUN
ecj-12166	26	27	.	.	PUNCT
ecj-12166	27	1	four	four	NUM
ecj-12166	27	2	good	good	ADJ
ecj-12166	27	3	reasons	reason	NOUN
ecj-12166	27	4	to	to	PART
ecj-12166	27	5	choose	choose	VERB
ecj-12166	27	6	ketamine	ketamine	PROPN
ecj-12166	27	7	in	in	ADP
ecj-12166	27	8	the	the	DET
ecj-12166	27	9	emergency	emergency	NOUN
ecj-12166	27	10	department	department	NOUN
ecj-12166	27	11	.	.	PUNCT
ecj-12166	28	1	a	a	DET
ecj-12166	28	2	case	case	NOUN
ecj-12166	28	3	series	series	NOUN
ecj-12166	28	4	and	and	CCONJ
ecj-12166	28	5	literature	literature	PROPN
ecj-12166	28	6	review	review	NOUN
ecj-12166	28	7	fabiana	fabiana	PROPN
ecj-12166	28	8	belviso,1	belviso,1	PROPN
ecj-12166	28	9	*	*	PUNCT
ecj-12166	28	10	erika	erika	PROPN
ecj-12166	28	11	poggiali,2	poggiali,2	PROPN
ecj-12166	28	12	*	*	PROPN
ecj-12166	28	13	eva	eva	PROPN
ecj-12166	28	14	ioannilli,2	ioannilli,2	PROPN
ecj-12166	28	15	davide	davide	PROPN
ecj-12166	28	16	bastoni,2	bastoni,2	PROPN
ecj-12166	28	17	monica	monica	PROPN
ecj-12166	28	18	stamate,2	stamate,2	VERB
ecj-12166	28	19	andrea	andrea	PROPN
ecj-12166	28	20	vercelli,2	vercelli,2	VERB
ecj-12166	28	21	alessandro	alessandro	PROPN
ecj-12166	28	22	riccardi3	riccardi3	VERB
ecj-12166	28	23	1vita	1vita	NUM
ecj-12166	28	24	-	-	PUNCT
ecj-12166	28	25	salute	salute	NOUN
ecj-12166	28	26	san	san	PROPN
ecj-12166	28	27	raffaele	raffaele	PROPN
ecj-12166	28	28	university	university	PROPN
ecj-12166	28	29	and	and	CCONJ
ecj-12166	28	30	emergency	emergency	PROPN
ecj-12166	28	31	department	department	NOUN
ecj-12166	28	32	,	,	PUNCT
ecj-12166	28	33	san	san	PROPN
ecj-12166	28	34	raffaele	raffaele	PROPN
ecj-12166	28	35	irccs	irccs	PROPN
ecj-12166	28	36	hospital	hospital	PROPN
ecj-12166	28	37	,	,	PUNCT
ecj-12166	28	38	milan	milan	PROPN
ecj-12166	28	39	;	;	PUNCT
ecj-12166	28	40	2emergency	2emergency	NUM
ecj-12166	28	41	department	department	NOUN
ecj-12166	28	42	,	,	PUNCT
ecj-12166	28	43	guglielmo	guglielmo	PROPN
ecj-12166	28	44	da	da	PROPN
ecj-12166	28	45	saliceto	saliceto	PROPN
ecj-12166	28	46	hospital	hospital	NOUN
ecj-12166	28	47	,	,	PUNCT
ecj-12166	28	48	piacenza	piacenza	NOUN
ecj-12166	28	49	;	;	PUNCT
ecj-12166	28	50	3emergency	3emergency	NUM
ecj-12166	28	51	services	service	NOUN
ecj-12166	28	52	and	and	CCONJ
ecj-12166	28	53	emergency	emergency	NOUN
ecj-12166	28	54	medicine	medicine	PROPN
ecj-12166	28	55	department	department	PROPN
ecj-12166	28	56	,	,	PUNCT
ecj-12166	28	57	santa	santa	PROPN
ecj-12166	28	58	corona	corona	PROPN
ecj-12166	28	59	hospital	hospital	NOUN
ecj-12166	28	60	,	,	PUNCT
ecj-12166	28	61	pietra	pietra	NOUN
ecj-12166	28	62	ligure	ligure	NOUN
ecj-12166	28	63	(	(	PUNCT
ecj-12166	28	64	sv	sv	PROPN
ecj-12166	28	65	)	)	PUNCT
ecj-12166	28	66	,	,	PUNCT
ecj-12166	28	67	italy	italy	PROPN
ecj-12166	28	68	*	*	PUNCT
ecj-12166	28	69	equally	equally	ADV
ecj-12166	28	70	contributed	contribute	VERB
ecj-12166	28	71	to	to	ADP
ecj-12166	28	72	the	the	DET
ecj-12166	28	73	work	work	NOUN
ecj-12166	28	74	highlights	highlight	NOUN
ecj-12166	28	75	ketamine	ketamine	PROPN
ecj-12166	28	76	is	be	AUX
ecj-12166	28	77	a	a	DET
ecj-12166	28	78	fast	fast	ADV
ecj-12166	28	79	-	-	PUNCT
ecj-12166	28	80	acting	act	VERB
ecj-12166	28	81	nmda	nmda	ADJ
ecj-12166	28	82	receptor	receptor	NOUN
ecj-12166	28	83	antagonist	antagonist	NOUN
ecj-12166	28	84	with	with	ADP
ecj-12166	28	85	a	a	DET
ecj-12166	28	86	dose	dose	NOUN
ecj-12166	28	87	-	-	PUNCT
ecj-12166	28	88	dependent	dependent	ADJ
ecj-12166	28	89	effect	effect	NOUN
ecj-12166	28	90	but	but	CCONJ
ecj-12166	28	91	with	with	ADP
ecj-12166	28	92	a	a	DET
ecj-12166	28	93	very	very	ADV
ecj-12166	28	94	broad	broad	ADJ
ecj-12166	28	95	action	action	NOUN
ecj-12166	28	96	on	on	ADP
ecj-12166	28	97	different	different	ADJ
ecj-12166	28	98	receptor	receptor	NOUN
ecj-12166	28	99	sites	site	NOUN
ecj-12166	28	100	.	.	PUNCT
ecj-12166	29	1	ketamine	ketamine	PROPN
ecj-12166	29	2	can	can	AUX
ecj-12166	29	3	be	be	AUX
ecj-12166	29	4	safely	safely	ADV
ecj-12166	29	5	used	use	VERB
ecj-12166	29	6	by	by	ADP
ecj-12166	29	7	emergency	emergency	NOUN
ecj-12166	29	8	clinicians	clinician	NOUN
ecj-12166	29	9	for	for	ADP
ecj-12166	29	10	procedural	procedural	ADJ
ecj-12166	29	11	sedation	sedation	NOUN
ecj-12166	29	12	,	,	PUNCT
ecj-12166	29	13	and	and	CCONJ
ecj-12166	29	14	pain	pain	NOUN
ecj-12166	29	15	management	management	NOUN
ecj-12166	29	16	,	,	PUNCT
ecj-12166	29	17	including	include	VERB
ecj-12166	29	18	pain	pain	NOUN
ecj-12166	29	19	unresponsive	unresponsive	ADJ
ecj-12166	29	20	to	to	ADP
ecj-12166	29	21	opioids	opioid	NOUN
ecj-12166	29	22	,	,	PUNCT
ecj-12166	29	23	neuropathic	neuropathic	ADJ
ecj-12166	29	24	pain	pain	NOUN
ecj-12166	29	25	,	,	PUNCT
ecj-12166	29	26	opioid	opioid	NOUN
ecj-12166	29	27	-	-	PUNCT
ecj-12166	29	28	induced	induce	VERB
ecj-12166	29	29	hyperalgesia	hyperalgesia	NOUN
ecj-12166	29	30	,	,	PUNCT
ecj-12166	29	31	and	and	CCONJ
ecj-12166	29	32	rapid	rapid	ADJ
ecj-12166	29	33	agitation	agitation	NOUN
ecj-12166	29	34	control	control	NOUN
ecj-12166	29	35	in	in	ADP
ecj-12166	29	36	benzodiazepine	benzodiazepine	NOUN
ecj-12166	29	37	resistant	resistant	ADJ
ecj-12166	29	38	alcohol	alcohol	NOUN
ecj-12166	29	39	withdrawal	withdrawal	NOUN
ecj-12166	29	40	syndrome	syndrome	NOUN
ecj-12166	29	41	and	and	CCONJ
ecj-12166	29	42	substance	substance	NOUN
ecj-12166	29	43	use	use	NOUN
ecj-12166	29	44	disorder	disorder	NOUN
ecj-12166	29	45	.	.	PUNCT
ecj-12166	30	1	other	other	ADJ
ecj-12166	30	2	indications	indication	NOUN
ecj-12166	30	3	include	include	VERB
ecj-12166	30	4	hyperactive	hyperactive	ADJ
ecj-12166	30	5	delirium	delirium	NOUN
ecj-12166	30	6	with	with	ADP
ecj-12166	30	7	severe	severe	ADJ
ecj-12166	30	8	agitation	agitation	NOUN
ecj-12166	30	9	,	,	PUNCT
ecj-12166	30	10	acute	acute	ADJ
ecj-12166	30	11	life	life	NOUN
ecj-12166	30	12	-	-	PUNCT
ecj-12166	30	13	threatening	threaten	VERB
ecj-12166	30	14	refractory	refractory	NOUN
ecj-12166	30	15	asthma	asthma	NOUN
ecj-12166	30	16	,	,	PUNCT
ecj-12166	30	17	refractory	refractory	NOUN
ecj-12166	30	18	status	status	NOUN
ecj-12166	30	19	epilepticus	epilepticus	NOUN
ecj-12166	30	20	,	,	PUNCT
ecj-12166	30	21	sedation	sedation	NOUN
ecj-12166	30	22	during	during	ADP
ecj-12166	30	23	non	non	ADJ
ecj-12166	30	24	-	-	ADJ
ecj-12166	30	25	invasive	invasive	ADJ
ecj-12166	30	26	ventilation	ventilation	NOUN
ecj-12166	30	27	,	,	PUNCT
ecj-12166	30	28	and	and	CCONJ
ecj-12166	30	29	palliative	palliative	ADJ
ecj-12166	30	30	sedation	sedation	NOUN
ecj-12166	30	31	in	in	ADP
ecj-12166	30	32	the	the	DET
ecj-12166	30	33	end	end	NOUN
ecj-12166	30	34	-	-	PUNCT
ecj-12166	30	35	of	of	ADP
ecj-12166	30	36	-	-	PUNCT
ecj-12166	30	37	life	life	NOUN
ecj-12166	30	38	.	.	PUNCT
ecj-12166	31	1	the	the	DET
ecj-12166	31	2	most	most	ADV
ecj-12166	31	3	common	common	ADJ
ecj-12166	31	4	routes	route	NOUN
ecj-12166	31	5	of	of	ADP
ecj-12166	31	6	administration	administration	NOUN
ecj-12166	31	7	are	be	AUX
ecj-12166	31	8	intramuscular	intramuscular	ADJ
ecj-12166	31	9	and	and	CCONJ
ecj-12166	31	10	intravenously	intravenously	ADV
ecj-12166	31	11	.	.	PUNCT
ecj-12166	32	1	caution	caution	NOUN
ecj-12166	32	2	must	must	AUX
ecj-12166	32	3	be	be	AUX
ecj-12166	32	4	maintained	maintain	VERB
ecj-12166	32	5	in	in	ADP
ecj-12166	32	6	patients	patient	NOUN
ecj-12166	32	7	with	with	ADP
ecj-12166	32	8	severe	severe	ADJ
ecj-12166	32	9	and	and	CCONJ
ecj-12166	32	10	uncontrolled	uncontrolled	ADJ
ecj-12166	32	11	hypertension	hypertension	NOUN
ecj-12166	32	12	and/or	and/or	CCONJ
ecj-12166	32	13	persistent	persistent	ADJ
ecj-12166	32	14	cardiovascular	cardiovascular	ADJ
ecj-12166	32	15	diseases	disease	NOUN
ecj-12166	32	16	.	.	PUNCT
ecj-12166	33	1	absolute	absolute	ADJ
ecj-12166	33	2	contraindications	contraindication	NOUN
ecj-12166	33	3	to	to	PART
ecj-12166	33	4	ketamine	ketamine	PROPN
ecj-12166	33	5	administration	administration	PROPN
ecj-12166	33	6	are	be	AUX
ecj-12166	33	7	pregnancy	pregnancy	NOUN
ecj-12166	33	8	,	,	PUNCT
ecj-12166	33	9	hepatic	hepatic	ADJ
ecj-12166	33	10	porphyria	porphyria	NOUN
ecj-12166	33	11	,	,	PUNCT
ecj-12166	33	12	and	and	CCONJ
ecj-12166	33	13	the	the	DET
ecj-12166	33	14	first	first	ADJ
ecj-12166	33	15	three	three	NUM
ecj-12166	33	16	months	month	NOUN
ecj-12166	33	17	of	of	ADP
ecj-12166	33	18	life	life	NOUN
ecj-12166	33	19	.	.	PUNCT
ecj-12166	34	1	non	non	ADJ
ecj-12166	35	1	-co	-co	PROPN
ecj-12166	35	2	mmerc	mmerc	PROPN
ecj-12166	35	3	ial	ial	PROPN
ecj-12166	35	4	us	us	PROPN
ecj-12166	35	5	e	e	NOUN
ecj-12166	35	6	o	o	NOUN
ecj-12166	35	7	nly	nly	ADV
ecj-12166	35	8	made	make	VERB
ecj-12166	35	9	,	,	PUNCT
ecj-12166	35	10	and	and	CCONJ
ecj-12166	35	11	ketamine	ketamine	PROPN
ecj-12166	35	12	was	be	AUX
ecj-12166	35	13	started	start	VERB
ecj-12166	35	14	at	at	ADP
ecj-12166	35	15	a	a	DET
ecj-12166	35	16	sub	sub	ADJ
ecj-12166	35	17	-	-	ADJ
ecj-12166	35	18	dissociative	dissociative	ADJ
ecj-12166	35	19	dose	dose	NOUN
ecj-12166	35	20	of	of	ADP
ecj-12166	35	21	0.5	0.5	NUM
ecj-12166	35	22	mg	mg	PROPN
ecj-12166	35	23	/	/	SYM
ecj-12166	35	24	kg	kg	PROPN
ecj-12166	35	25	/	/	SYM
ecj-12166	35	26	h	h	NOUN
ecj-12166	35	27	iv	iv	NOUN
ecj-12166	35	28	with	with	ADP
ecj-12166	35	29	complete	complete	ADJ
ecj-12166	35	30	symptom	symptom	NOUN
ecj-12166	35	31	management	management	NOUN
ecj-12166	35	32	.	.	PUNCT
ecj-12166	36	1	case	case	NOUN
ecj-12166	36	2	#	#	SYM
ecj-12166	36	3	2	2	NUM
ecj-12166	36	4	a	a	DET
ecj-12166	36	5	29	29	NUM
ecj-12166	36	6	-	-	PUNCT
ecj-12166	36	7	year	year	NOUN
ecj-12166	36	8	-	-	PUNCT
ecj-12166	36	9	old	old	ADJ
ecj-12166	36	10	man	man	NOUN
ecj-12166	36	11	was	be	AUX
ecj-12166	36	12	found	find	VERB
ecj-12166	36	13	agitated	agitated	ADJ
ecj-12166	36	14	on	on	ADP
ecj-12166	36	15	the	the	DET
ecj-12166	36	16	street	street	NOUN
ecj-12166	36	17	as	as	ADP
ecj-12166	36	18	a	a	DET
ecj-12166	36	19	result	result	NOUN
ecj-12166	36	20	of	of	ADP
ecj-12166	36	21	an	an	DET
ecj-12166	36	22	alcohol	alcohol	NOUN
ecj-12166	36	23	and	and	CCONJ
ecj-12166	36	24	substance	substance	NOUN
ecj-12166	36	25	use	use	NOUN
ecj-12166	36	26	disorder	disorder	NOUN
ecj-12166	36	27	.	.	PUNCT
ecj-12166	37	1	he	he	PRON
ecj-12166	37	2	was	be	AUX
ecj-12166	37	3	sent	send	VERB
ecj-12166	37	4	to	to	ADP
ecj-12166	37	5	our	our	PRON
ecj-12166	37	6	ed	ed	NOUN
ecj-12166	37	7	with	with	ADP
ecj-12166	37	8	a	a	DET
ecj-12166	37	9	diagnosis	diagnosis	NOUN
ecj-12166	37	10	of	of	ADP
ecj-12166	37	11	severe	severe	ADJ
ecj-12166	37	12	bdz	bdz	NOUN
ecj-12166	37	13	-	-	PUNCT
ecj-12166	37	14	resistant	resistant	ADJ
ecj-12166	37	15	psychomotor	psychomotor	NOUN
ecj-12166	37	16	agitation	agitation	NOUN
ecj-12166	37	17	after	after	ADP
ecj-12166	37	18	being	be	AUX
ecj-12166	37	19	treated	treat	VERB
ecj-12166	37	20	with	with	ADP
ecj-12166	37	21	midazolam	midazolam	PROPN
ecj-12166	37	22	(	(	PUNCT
ecj-12166	37	23	15	15	NUM
ecj-12166	37	24	mg	mg	NOUN
ecj-12166	37	25	i	i	PRON
ecj-12166	37	26	m	m	VERB
ecj-12166	37	27	plus	plus	CCONJ
ecj-12166	37	28	10	10	NUM
ecj-12166	37	29	mg	mg	NUM
ecj-12166	37	30	iv	iv	NUM
ecj-12166	37	31	)	)	PUNCT
ecj-12166	37	32	by	by	ADP
ecj-12166	37	33	the	the	DET
ecj-12166	37	34	emergency	emergency	NOUN
ecj-12166	37	35	medical	medical	ADJ
ecj-12166	37	36	service	service	NOUN
ecj-12166	37	37	.	.	PUNCT
ecj-12166	38	1	in	in	ADP
ecj-12166	38	2	the	the	DET
ecj-12166	38	3	ed	ed	NOUN
ecj-12166	38	4	,	,	PUNCT
ecj-12166	38	5	ketamine	ketamine	PROPN
ecj-12166	38	6	was	be	AUX
ecj-12166	38	7	started	start	VERB
ecj-12166	38	8	at	at	ADP
ecj-12166	38	9	a	a	DET
ecj-12166	38	10	dissociative	dissociative	ADJ
ecj-12166	38	11	dose	dose	NOUN
ecj-12166	38	12	of	of	ADP
ecj-12166	38	13	1	1	NUM
ecj-12166	38	14	mg	mg	PROPN
ecj-12166	38	15	/	/	SYM
ecj-12166	38	16	kg	kg	PROPN
ecj-12166	38	17	/	/	SYM
ecj-12166	38	18	h	h	NOUN
ecj-12166	38	19	iv	iv	NOUN
ecj-12166	38	20	,	,	PUNCT
ecj-12166	38	21	with	with	ADP
ecj-12166	38	22	optimal	optimal	ADJ
ecj-12166	38	23	symptom	symptom	NOUN
ecj-12166	38	24	management	management	NOUN
ecj-12166	38	25	.	.	PUNCT
ecj-12166	39	1	case	case	NOUN
ecj-12166	39	2	#	#	SYM
ecj-12166	39	3	3	3	NUM
ecj-12166	39	4	a	a	DET
ecj-12166	39	5	51	51	NUM
ecj-12166	39	6	-	-	PUNCT
ecj-12166	39	7	year	year	NOUN
ecj-12166	39	8	-	-	PUNCT
ecj-12166	39	9	old	old	ADJ
ecj-12166	39	10	woman	woman	NOUN
ecj-12166	39	11	with	with	ADP
ecj-12166	39	12	a	a	DET
ecj-12166	39	13	history	history	NOUN
ecj-12166	39	14	of	of	ADP
ecj-12166	39	15	obesity	obesity	NOUN
ecj-12166	39	16	and	and	CCONJ
ecj-12166	39	17	bipolar	bipolar	ADJ
ecj-12166	39	18	disorder	disorder	NOUN
ecj-12166	39	19	was	be	AUX
ecj-12166	39	20	brought	bring	VERB
ecj-12166	39	21	to	to	ADP
ecj-12166	39	22	our	our	PRON
ecj-12166	39	23	ed	ed	NOUN
ecj-12166	39	24	by	by	ADP
ecj-12166	39	25	the	the	DET
ecj-12166	39	26	police	police	NOUN
ecj-12166	39	27	for	for	ADP
ecj-12166	39	28	psychotic	psychotic	ADJ
ecj-12166	39	29	delirium	delirium	NOUN
ecj-12166	39	30	.	.	PUNCT
ecj-12166	40	1	she	she	PRON
ecj-12166	40	2	was	be	AUX
ecj-12166	40	3	immediately	immediately	ADV
ecj-12166	40	4	treated	treat	VERB
ecj-12166	40	5	with	with	ADP
ecj-12166	40	6	ketamine	ketamine	PROPN
ecj-12166	40	7	at	at	ADP
ecj-12166	40	8	a	a	DET
ecj-12166	40	9	dissociative	dissociative	ADJ
ecj-12166	40	10	dose	dose	NOUN
ecj-12166	40	11	of	of	ADP
ecj-12166	40	12	5	5	NUM
ecj-12166	40	13	mg	mg	NOUN
ecj-12166	40	14	/	/	SYM
ecj-12166	40	15	kg	kg	PROPN
ecj-12166	41	1	i	i	PRON
ecj-12166	41	2	m	m	VERB
ecj-12166	41	3	with	with	ADP
ecj-12166	41	4	immediate	immediate	ADJ
ecj-12166	41	5	sedation	sedation	NOUN
ecj-12166	41	6	.	.	PUNCT
ecj-12166	42	1	when	when	SCONJ
ecj-12166	42	2	the	the	DET
ecj-12166	42	3	patient	patient	NOUN
ecj-12166	42	4	was	be	AUX
ecj-12166	42	5	dissociated	dissociate	VERB
ecj-12166	42	6	,	,	PUNCT
ecj-12166	42	7	delorazepam	delorazepam	VERB
ecj-12166	42	8	5	5	NUM
ecj-12166	42	9	mg	mg	NOUN
ecj-12166	42	10	iv	iv	NUM
ecj-12166	42	11	was	be	AUX
ecj-12166	42	12	infused	infuse	VERB
ecj-12166	42	13	,	,	PUNCT
ecj-12166	42	14	and	and	CCONJ
ecj-12166	42	15	she	she	PRON
ecj-12166	42	16	was	be	AUX
ecj-12166	42	17	transferred	transfer	VERB
ecj-12166	42	18	to	to	ADP
ecj-12166	42	19	the	the	DET
ecj-12166	42	20	psychiatric	psychiatric	ADJ
ecj-12166	42	21	inpatient	inpatient	PROPN
ecj-12166	42	22	clinic	clinic	PROPN
ecj-12166	42	23	.	.	PUNCT
ecj-12166	43	1	case	case	NOUN
ecj-12166	43	2	#	#	SYM
ecj-12166	43	3	4	4	NUM
ecj-12166	43	4	a	a	DET
ecj-12166	43	5	50	50	NUM
ecj-12166	43	6	-	-	PUNCT
ecj-12166	43	7	year	year	NOUN
ecj-12166	43	8	-	-	PUNCT
ecj-12166	43	9	old	old	ADJ
ecj-12166	43	10	man	man	NOUN
ecj-12166	43	11	with	with	ADP
ecj-12166	43	12	surgical	surgical	ADJ
ecj-12166	43	13	monokidney	monokidney	NOUN
ecj-12166	43	14	presented	present	VERB
ecj-12166	43	15	to	to	ADP
ecj-12166	43	16	our	our	PRON
ecj-12166	43	17	ed	ed	NOUN
ecj-12166	43	18	complaining	complain	VERB
ecj-12166	43	19	of	of	ADP
ecj-12166	43	20	renal	renal	ADJ
ecj-12166	43	21	colic	colic	NOUN
ecj-12166	43	22	.	.	PUNCT
ecj-12166	44	1	despite	despite	SCONJ
ecj-12166	44	2	receiving	receive	VERB
ecj-12166	44	3	massive	massive	ADJ
ecj-12166	44	4	doses	dose	NOUN
ecj-12166	44	5	of	of	ADP
ecj-12166	44	6	morphine	morphine	NOUN
ecj-12166	44	7	iv	iv	NUM
ecj-12166	44	8	(	(	PUNCT
ecj-12166	44	9	3	3	NUM
ecj-12166	44	10	consecutive	consecutive	ADJ
ecj-12166	44	11	boluses	bolus	NOUN
ecj-12166	44	12	of	of	ADP
ecj-12166	44	13	0.1	0.1	NUM
ecj-12166	44	14	mg	mg	PROPN
ecj-12166	44	15	/	/	SYM
ecj-12166	44	16	kg	kg	PROPN
ecj-12166	44	17	iv	iv	NUM
ecj-12166	44	18	)	)	PUNCT
ecj-12166	44	19	,	,	PUNCT
ecj-12166	44	20	he	he	PRON
ecj-12166	44	21	continued	continue	VERB
ecj-12166	44	22	to	to	PART
ecj-12166	44	23	suffer	suffer	VERB
ecj-12166	44	24	intense	intense	ADJ
ecj-12166	44	25	pain	pain	NOUN
ecj-12166	44	26	(	(	PUNCT
ecj-12166	44	27	nrs	nrs	NOUN
ecj-12166	44	28	10/10	10/10	NUM
ecj-12166	44	29	)	)	PUNCT
ecj-12166	44	30	.	.	PUNCT
ecj-12166	45	1	ketamine	ketamine	PROPN
ecj-12166	45	2	was	be	AUX
ecj-12166	45	3	given	give	VERB
ecj-12166	45	4	intravenously	intravenously	ADV
ecj-12166	45	5	at	at	ADP
ecj-12166	45	6	an	an	DET
ecj-12166	45	7	analgesic	analgesic	ADJ
ecj-12166	45	8	bolus	bolus	NOUN
ecj-12166	45	9	dose	dose	NOUN
ecj-12166	45	10	of	of	ADP
ecj-12166	45	11	0.2	0.2	NUM
ecj-12166	45	12	mg	mg	PROPN
ecj-12166	45	13	/	/	SYM
ecj-12166	45	14	kg	kg	PROPN
ecj-12166	45	15	,	,	PUNCT
ecj-12166	45	16	which	which	PRON
ecj-12166	45	17	provided	provide	VERB
ecj-12166	45	18	immediate	immediate	ADJ
ecj-12166	45	19	pain	pain	NOUN
ecj-12166	45	20	relief	relief	NOUN
ecj-12166	45	21	.	.	PUNCT
ecj-12166	46	1	except	except	SCONJ
ecj-12166	46	2	for	for	ADP
ecj-12166	46	3	patient	patient	NOUN
ecj-12166	46	4	4	4	NUM
ecj-12166	46	5	,	,	PUNCT
ecj-12166	46	6	who	who	PRON
ecj-12166	46	7	experienced	experience	VERB
ecj-12166	46	8	moderate	moderate	ADJ
ecj-12166	46	9	anxiety	anxiety	NOUN
ecj-12166	46	10	,	,	PUNCT
ecj-12166	46	11	which	which	PRON
ecj-12166	46	12	was	be	AUX
ecj-12166	46	13	treated	treat	VERB
ecj-12166	46	14	immediately	immediately	ADV
ecj-12166	46	15	and	and	CCONJ
ecj-12166	46	16	successfully	successfully	ADV
ecj-12166	46	17	with	with	ADP
ecj-12166	46	18	midazolam	midazolam	PROPN
ecj-12166	46	19	2	2	NUM
ecj-12166	46	20	mg	mg	NUM
ecj-12166	46	21	iv	iv	NUM
ecj-12166	46	22	,	,	PUNCT
ecj-12166	46	23	none	none	NOUN
ecj-12166	46	24	of	of	ADP
ecj-12166	46	25	the	the	DET
ecj-12166	46	26	patients	patient	NOUN
ecj-12166	46	27	experienced	experience	VERB
ecj-12166	46	28	side	side	NOUN
ecj-12166	46	29	effects	effect	NOUN
ecj-12166	46	30	.	.	PUNCT
ecj-12166	47	1	discussion	discussion	NOUN
ecj-12166	47	2	ketamine	ketamine	PROPN
ecj-12166	47	3	is	be	AUX
ecj-12166	47	4	a	a	DET
ecj-12166	47	5	stereoselective	stereoselective	ADJ
ecj-12166	47	6	non	non	ADJ
ecj-12166	47	7	-	-	ADJ
ecj-12166	47	8	competitive	competitive	ADJ
ecj-12166	47	9	antagonist	antagonist	NOUN
ecj-12166	47	10	of	of	ADP
ecj-12166	47	11	the	the	DET
ecj-12166	47	12	ionotropic	ionotropic	ADJ
ecj-12166	47	13	receptor	receptor	NOUN
ecj-12166	47	14	of	of	ADP
ecj-12166	47	15	nmda	nmda	NOUN
ecj-12166	47	16	that	that	PRON
ecj-12166	47	17	reduces	reduce	VERB
ecj-12166	47	18	calcium	calcium	NOUN
ecj-12166	47	19	ion	ion	NOUN
ecj-12166	47	20	influx	influx	NOUN
ecj-12166	47	21	through	through	ADP
ecj-12166	47	22	this	this	DET
ecj-12166	47	23	channel	channel	NOUN
ecj-12166	47	24	and	and	CCONJ
ecj-12166	47	25	therefore	therefore	ADV
ecj-12166	47	26	prevents	prevent	VERB
ecj-12166	47	27	neuronal	neuronal	ADJ
ecj-12166	47	28	activation	activation	NOUN
ecj-12166	47	29	required	require	VERB
ecj-12166	47	30	for	for	ADP
ecj-12166	47	31	conscious	conscious	ADJ
ecj-12166	47	32	state,1	state,1	NOUN
ecj-12166	47	33	resulting	result	VERB
ecj-12166	47	34	in	in	ADP
ecj-12166	47	35	a	a	DET
ecj-12166	47	36	non	non	ADJ
ecj-12166	47	37	-	-	ADJ
ecj-12166	47	38	competitively	competitively	ADV
ecj-12166	47	39	block	block	NOUN
ecj-12166	47	40	of	of	ADP
ecj-12166	47	41	the	the	DET
ecj-12166	47	42	opening	opening	NOUN
ecj-12166	47	43	of	of	ADP
ecj-12166	47	44	glutamatergic	glutamatergic	ADJ
ecj-12166	47	45	channels	channel	NOUN
ecj-12166	47	46	,	,	PUNCT
ecj-12166	47	47	mainly	mainly	ADV
ecj-12166	47	48	in	in	ADP
ecj-12166	47	49	the	the	DET
ecj-12166	47	50	prefrontal	prefrontal	ADJ
ecj-12166	47	51	cortex	cortex	NOUN
ecj-12166	47	52	and	and	CCONJ
ecj-12166	47	53	hippocampus	hippocampus	NOUN
ecj-12166	47	54	.	.	PUNCT
ecj-12166	48	1	however	however	ADV
ecj-12166	48	2	,	,	PUNCT
ecj-12166	48	3	the	the	DET
ecj-12166	48	4	analgesic	analgesic	ADJ
ecj-12166	48	5	effects	effect	NOUN
ecj-12166	48	6	of	of	ADP
ecj-12166	48	7	ketamine	ketamine	PROPN
ecj-12166	48	8	are	be	AUX
ecj-12166	48	9	diverse	diverse	ADJ
ecj-12166	48	10	and	and	CCONJ
ecj-12166	48	11	multifaceted	multifaceted	ADJ
ecj-12166	48	12	,	,	PUNCT
ecj-12166	48	13	with	with	ADP
ecj-12166	48	14	effects	effect	NOUN
ecj-12166	48	15	on	on	ADP
ecj-12166	48	16	dopaminergic	dopaminergic	ADJ
ecj-12166	48	17	,	,	PUNCT
ecj-12166	48	18	adrenergic	adrenergic	ADJ
ecj-12166	48	19	,	,	PUNCT
ecj-12166	48	20	serotoninergic	serotoninergic	ADJ
ecj-12166	48	21	,	,	PUNCT
ecj-12166	48	22	opioid	opioid	ADJ
ecj-12166	48	23	,	,	PUNCT
ecj-12166	48	24	and	and	CCONJ
ecj-12166	48	25	cholinergic	cholinergic	ADJ
ecj-12166	48	26	receptors	receptor	NOUN
ecj-12166	48	27	,	,	PUNCT
ecj-12166	48	28	α	α	NOUN
ecj-12166	48	29	-	-	PUNCT
ecj-12166	48	30	amino-3	amino-3	ADJ
ecj-12166	48	31	-	-	PUNCT
ecj-12166	48	32	hydroxy-5	hydroxy-5	NUM
ecj-12166	48	33	-	-	PUNCT
ecj-12166	48	34	methyl-4	methyl-4	NOUN
ecj-12166	48	35	-	-	PUNCT
ecj-12166	48	36	isoxazolepropionic	isoxazolepropionic	NOUN
ecj-12166	48	37	acid	acid	NOUN
ecj-12166	48	38	receptor	receptor	NOUN
ecj-12166	48	39	(	(	PUNCT
ecj-12166	48	40	ampar	ampar	NOUN
ecj-12166	48	41	)	)	PUNCT
ecj-12166	48	42	and	and	CCONJ
ecj-12166	48	43	on	on	ADP
ecj-12166	48	44	spinal	spinal	ADJ
ecj-12166	48	45	gaba	gaba	NOUN
ecj-12166	48	46	interneurons	interneuron	NOUN
ecj-12166	48	47	:	:	PUNCT
ecj-12166	48	48	ketamine	ketamine	PROPN
ecj-12166	48	49	modulates	modulate	VERB
ecj-12166	48	50	the	the	DET
ecj-12166	48	51	reuptake	reuptake	NOUN
ecj-12166	48	52	of	of	ADP
ecj-12166	48	53	serotonin	serotonin	NOUN
ecj-12166	48	54	,	,	PUNCT
ecj-12166	48	55	dopamine	dopamine	NOUN
ecj-12166	48	56	,	,	PUNCT
ecj-12166	48	57	and	and	CCONJ
ecj-12166	48	58	norepinephrine	norepinephrine	NOUN
ecj-12166	48	59	,	,	PUNCT
ecj-12166	48	60	causing	cause	VERB
ecj-12166	48	61	a	a	DET
ecj-12166	48	62	paradoxical	paradoxical	ADJ
ecj-12166	48	63	increase	increase	NOUN
ecj-12166	48	64	in	in	ADP
ecj-12166	48	65	glutamate	glutamate	NOUN
ecj-12166	48	66	with	with	ADP
ecj-12166	48	67	stimulation	stimulation	NOUN
ecj-12166	48	68	of	of	ADP
ecj-12166	48	69	the	the	DET
ecj-12166	48	70	descending	descend	VERB
ecj-12166	48	71	inhibitory	inhibitory	ADJ
ecj-12166	48	72	pathways	pathway	NOUN
ecj-12166	48	73	,	,	PUNCT
ecj-12166	48	74	and	and	CCONJ
ecj-12166	48	75	having	have	VERB
ecj-12166	48	76	an	an	DET
ecj-12166	48	77	antidepressant	antidepressant	ADJ
ecj-12166	48	78	action	action	NOUN
ecj-12166	48	79	caused	cause	VERB
ecj-12166	48	80	by	by	ADP
ecj-12166	48	81	actions	action	NOUN
ecj-12166	48	82	on	on	ADP
ecj-12166	48	83	several	several	ADJ
ecj-12166	48	84	levels.2	levels.2	NOUN
ecj-12166	48	85	it	it	PRON
ecj-12166	48	86	was	be	AUX
ecj-12166	48	87	first	first	ADV
ecj-12166	48	88	synthesized	synthesize	VERB
ecj-12166	48	89	by	by	ADP
ecj-12166	48	90	calvin	calvin	PROPN
ecj-12166	48	91	stevens	stevens	PROPN
ecj-12166	48	92	of	of	ADP
ecj-12166	48	93	the	the	DET
ecj-12166	48	94	parke	parke	PROPN
ecj-12166	48	95	-	-	PUNCT
ecj-12166	48	96	davis	davis	PROPN
ecj-12166	48	97	pharmaceutical	pharmaceutical	NOUN
ecj-12166	48	98	company	company	NOUN
ecj-12166	48	99	in	in	ADP
ecj-12166	48	100	1962	1962	NUM
ecj-12166	48	101	(	(	PUNCT
ecj-12166	48	102	ann	ann	PROPN
ecj-12166	48	103	arbor	arbor	PROPN
ecj-12166	48	104	,	,	PUNCT
ecj-12166	48	105	michigan	michigan	PROPN
ecj-12166	48	106	)	)	PUNCT
ecj-12166	48	107	while	while	SCONJ
ecj-12166	48	108	searching	search	VERB
ecj-12166	48	109	for	for	ADP
ecj-12166	48	110	an	an	DET
ecj-12166	48	111	alternative	alternative	NOUN
ecj-12166	48	112	to	to	ADP
ecj-12166	48	113	the	the	DET
ecj-12166	48	114	potent	potent	ADJ
ecj-12166	48	115	hallucinogenic	hallucinogenic	ADJ
ecj-12166	48	116	agent	agent	NOUN
ecj-12166	48	117	phencyclidine,3	phencyclidine,3	NOUN
ecj-12166	48	118	and	and	CCONJ
ecj-12166	48	119	later	later	ADV
ecj-12166	48	120	,	,	PUNCT
ecj-12166	48	121	it	it	PRON
ecj-12166	48	122	was	be	AUX
ecj-12166	48	123	approved	approve	VERB
ecj-12166	48	124	by	by	ADP
ecj-12166	48	125	the	the	DET
ecj-12166	48	126	fda	fda	PROPN
ecj-12166	48	127	as	as	ADP
ecj-12166	48	128	an	an	DET
ecj-12166	48	129	anesthetic	anesthetic	ADJ
ecj-12166	48	130	agent	agent	NOUN
ecj-12166	48	131	in	in	ADP
ecj-12166	48	132	1970.4	1970.4	NUM
ecj-12166	48	133	ketamine	ketamine	NOUN
ecj-12166	48	134	is	be	AUX
ecj-12166	48	135	unique	unique	ADJ
ecj-12166	48	136	among	among	ADP
ecj-12166	48	137	drugs	drug	NOUN
ecj-12166	48	138	for	for	ADP
ecj-12166	48	139	its	its	PRON
ecj-12166	48	140	ability	ability	NOUN
ecj-12166	48	141	to	to	PART
ecj-12166	48	142	produce	produce	VERB
ecj-12166	48	143	different	different	ADJ
ecj-12166	48	144	effects	effect	NOUN
ecj-12166	48	145	,	,	PUNCT
ecj-12166	48	146	from	from	ADP
ecj-12166	48	147	analgesic	analgesic	ADJ
ecj-12166	48	148	to	to	ADP
ecj-12166	48	149	dissociative	dissociative	ADJ
ecj-12166	48	150	,	,	PUNCT
ecj-12166	48	151	depending	depend	VERB
ecj-12166	48	152	on	on	ADP
ecj-12166	48	153	the	the	DET
ecj-12166	48	154	dosage2	dosage2	NOUN
ecj-12166	48	155	(	(	PUNCT
ecj-12166	48	156	tables	table	NOUN
ecj-12166	48	157	1	1	NUM
ecj-12166	48	158	and	and	CCONJ
ecj-12166	48	159	2	2	NUM
ecj-12166	48	160	)	)	PUNCT
ecj-12166	48	161	.	.	PUNCT
ecj-12166	49	1	its	its	PRON
ecj-12166	49	2	potential	potential	ADJ
ecj-12166	49	3	benefits	benefit	NOUN
ecj-12166	49	4	are	be	AUX
ecj-12166	49	5	evident	evident	ADJ
ecj-12166	49	6	in	in	ADP
ecj-12166	49	7	mini	mini	ADJ
ecj-12166	49	8	review	review	NOUN
ecj-12166	49	9	table	table	NOUN
ecj-12166	49	10	1	1	NUM
ecj-12166	49	11	.	.	PUNCT
ecj-12166	49	12	dosages	dosage	NOUN
ecj-12166	49	13	and	and	CCONJ
ecj-12166	49	14	effects	effect	NOUN
ecj-12166	49	15	of	of	ADP
ecj-12166	49	16	ketamine	ketamine	PROPN
ecj-12166	49	17	in	in	ADP
ecj-12166	49	18	adults	adult	NOUN
ecj-12166	49	19	.	.	PUNCT
ecj-12166	50	1	adult	adult	NOUN
ecj-12166	50	2	dose	dose	NOUN
ecj-12166	50	3	analgesia	analgesia	NOUN
ecj-12166	50	4	•	•	ADV
ecj-12166	50	5	0.15	0.15	NUM
ecj-12166	50	6	-	-	SYM
ecj-12166	50	7	0.3	0.3	NUM
ecj-12166	50	8	mg	mg	PROPN
ecj-12166	50	9	/	/	SYM
ecj-12166	50	10	kg	kg	PROPN
ecj-12166	50	11	iv	iv	PROPN
ecj-12166	50	12	/	/	SYM
ecj-12166	50	13	io	io	X
ecj-12166	50	14	(	(	PUNCT
ecj-12166	50	15	slow	slow	ADJ
ecj-12166	50	16	push	push	NOUN
ecj-12166	50	17	)	)	PUNCT
ecj-12166	50	18	,	,	PUNCT
ecj-12166	50	19	followed	follow	VERB
ecj-12166	50	20	by	by	ADP
ecj-12166	50	21	0.15	0.15	NUM
ecj-12166	50	22	-	-	SYM
ecj-12166	50	23	0.3	0.3	NUM
ecj-12166	50	24	mg	mg	PROPN
ecj-12166	50	25	/	/	SYM
ecj-12166	50	26	kg	kg	PROPN
ecj-12166	50	27	/	/	SYM
ecj-12166	50	28	h	h	NOUN
ecj-12166	50	29	iv	iv	PROPN
ecj-12166	50	30	/	/	SYM
ecj-12166	50	31	io	io	X
ecj-12166	50	32	(	(	PUNCT
ecj-12166	50	33	continuous	continuous	ADJ
ecj-12166	50	34	infusion	infusion	NOUN
ecj-12166	50	35	)	)	PUNCT
ecj-12166	50	36	•	•	ADV
ecj-12166	50	37	0.5	0.5	NUM
ecj-12166	50	38	mg	mg	PROPN
ecj-12166	50	39	/	/	SYM
ecj-12166	50	40	kg	kg	PROPN
ecj-12166	50	41	i	i	NOUN
ecj-12166	50	42	m	m	PROPN
ecj-12166	50	43	,	,	PUNCT
ecj-12166	50	44	repeat	repeat	VERB
ecj-12166	50	45	0.3	0.3	NUM
ecj-12166	50	46	mg	mg	PROPN
ecj-12166	50	47	/	/	SYM
ecj-12166	50	48	kg	kg	PROPN
ecj-12166	50	49	after	after	SCONJ
ecj-12166	50	50	45	45	NUM
ecj-12166	50	51	min	min	NOUN
ecj-12166	50	52	•	•	ADP
ecj-12166	50	53	1	1	NUM
ecj-12166	50	54	mg	mg	NUM
ecj-12166	50	55	/	/	SYM
ecj-12166	50	56	kg	kg	PROPN
ecj-12166	50	57	in	in	ADP
ecj-12166	50	58	procedural	procedural	ADJ
ecj-12166	50	59	sedation	sedation	NOUN
ecj-12166	50	60	•	•	NOUN
ecj-12166	50	61	1	1	NUM
ecj-12166	50	62	-	-	SYM
ecj-12166	50	63	2	2	NUM
ecj-12166	50	64	mg	mg	PROPN
ecj-12166	50	65	/	/	SYM
ecj-12166	50	66	kg	kg	PROPN
ecj-12166	50	67	(	(	PUNCT
ecj-12166	50	68	iv	iv	PROPN
ecj-12166	50	69	/	/	SYM
ecj-12166	50	70	io	io	NOUN
ecj-12166	50	71	)	)	PUNCT
ecj-12166	50	72	dissociative	dissociative	NOUN
ecj-12166	50	73	dose	dose	VERB
ecj-12166	50	74	•	•	NUM
ecj-12166	50	75	1	1	NUM
ecj-12166	50	76	-	-	SYM
ecj-12166	50	77	2	2	NUM
ecj-12166	50	78	mg	mg	PROPN
ecj-12166	50	79	/	/	SYM
ecj-12166	50	80	kg	kg	PROPN
ecj-12166	50	81	iv	iv	PROPN
ecj-12166	50	82	/	/	SYM
ecj-12166	50	83	io	io	NOUN
ecj-12166	50	84	•	•	NUM
ecj-12166	51	1	5	5	NUM
ecj-12166	51	2	mg	mg	PROPN
ecj-12166	51	3	/	/	SYM
ecj-12166	51	4	kg	kg	NOUN
ecj-12166	52	1	i	i	PRON
ecj-12166	52	2	m	m	VERB
ecj-12166	52	3	(	(	PUNCT
ecj-12166	52	4	max	max	PROPN
ecj-12166	52	5	single	single	ADJ
ecj-12166	52	6	/	/	SYM
ecj-12166	52	7	cumulative	cumulative	ADJ
ecj-12166	52	8	dose	dose	NOUN
ecj-12166	52	9	500	500	NUM
ecj-12166	52	10	mg	mg	NOUN
ecj-12166	52	11	)	)	PUNCT
ecj-12166	52	12	maximum	maximum	ADJ
ecj-12166	52	13	volume	volume	NOUN
ecj-12166	52	14	of	of	ADP
ecj-12166	52	15	administration	administration	NOUN
ecj-12166	52	16	:	:	PUNCT
ecj-12166	52	17	deltoid	deltoid	NOUN
ecj-12166	52	18	:	:	PUNCT
ecj-12166	52	19	2	2	NUM
ecj-12166	52	20	ml	ml	ADP
ecj-12166	52	21	lateral	lateral	ADJ
ecj-12166	52	22	thigh	thigh	NOUN
ecj-12166	52	23	:	:	PUNCT
ecj-12166	52	24	4	4	NUM
ecj-12166	52	25	-	-	SYM
ecj-12166	52	26	5	5	NUM
ecj-12166	52	27	ml	ml	NOUN
ecj-12166	52	28	gluteal	gluteal	NOUN
ecj-12166	52	29	:	:	PUNCT
ecj-12166	52	30	5	5	NUM
ecj-12166	52	31	ml	ml	NOUN
ecj-12166	52	32	sub	sub	ADJ
ecj-12166	52	33	-	-	ADJ
ecj-12166	52	34	dissociative	dissociative	ADJ
ecj-12166	52	35	dose	dose	VERB
ecj-12166	52	36	•	•	NUM
ecj-12166	52	37	0.5	0.5	NUM
ecj-12166	52	38	-	-	SYM
ecj-12166	52	39	0.7	0.7	NUM
ecj-12166	52	40	mg	mg	PROPN
ecj-12166	52	41	/	/	SYM
ecj-12166	52	42	kg	kg	PROPN
ecj-12166	52	43	iv	iv	PROPN
ecj-12166	52	44	/	/	SYM
ecj-12166	52	45	io	io	X
ecj-12166	52	46	iv	iv	PROPN
ecj-12166	52	47	,	,	PUNCT
ecj-12166	52	48	intravenous	intravenous	NOUN
ecj-12166	52	49	.	.	PUNCT
ecj-12166	53	1	io	io	NOUN
ecj-12166	53	2	,	,	PUNCT
ecj-12166	53	3	intraosseus	intraosseus	NOUN
ecj-12166	53	4	.	.	PUNCT
ecj-12166	54	1	i	i	PRON
ecj-12166	54	2	m	m	VERB
ecj-12166	54	3	,	,	PUNCT
ecj-12166	54	4	intramuscular	intramuscular	ADJ
ecj-12166	54	5	.	.	PUNCT
ecj-12166	55	1	table	table	NOUN
ecj-12166	55	2	2	2	NUM
ecj-12166	55	3	.	.	PUNCT
ecj-12166	55	4	dosages	dosage	NOUN
ecj-12166	55	5	and	and	CCONJ
ecj-12166	55	6	effects	effect	NOUN
ecj-12166	55	7	of	of	ADP
ecj-12166	55	8	ketamine	ketamine	NOUN
ecj-12166	55	9	in	in	ADP
ecj-12166	55	10	pediatrics	pediatric	NOUN
ecj-12166	55	11	.	.	PUNCT
ecj-12166	56	1	pediatric	pediatric	ADJ
ecj-12166	56	2	dose	dose	PROPN
ecj-12166	56	3	(	(	PUNCT
ecj-12166	56	4	aged	aged	ADJ
ecj-12166	56	5	>	>	X
ecj-12166	56	6	6	6	NUM
ecj-12166	56	7	months	month	NOUN
ecj-12166	56	8	)	)	PUNCT
ecj-12166	56	9	analgesia	analgesia	PROPN
ecj-12166	56	10	intravenous	intravenous	ADJ
ecj-12166	56	11	/	/	SYM
ecj-12166	56	12	intraosseous	intraosseous	ADJ
ecj-12166	56	13	•	•	NOUN
ecj-12166	56	14	0.15	0.15	NUM
ecj-12166	56	15	-	-	SYM
ecj-12166	56	16	0.33	0.33	NUM
ecj-12166	56	17	mg	mg	NUM
ecj-12166	56	18	/	/	SYM
ecj-12166	56	19	kg	kg	PROPN
ecj-12166	56	20	slow	slow	ADJ
ecj-12166	56	21	push	push	VERB
ecj-12166	56	22	•	•	NUM
ecj-12166	56	23	maximum	maximum	ADJ
ecj-12166	56	24	single	single	ADJ
ecj-12166	56	25	dose	dose	NOUN
ecj-12166	56	26	20	20	NUM
ecj-12166	56	27	mg	mg	NUM
ecj-12166	56	28	•	•	NUM
ecj-12166	56	29	repeat	repeat	VERB
ecj-12166	56	30	every	every	DET
ecj-12166	56	31	2	2	NUM
ecj-12166	56	32	-	-	SYM
ecj-12166	56	33	3	3	NUM
ecj-12166	56	34	minutes	minute	NOUN
ecj-12166	56	35	to	to	ADP
ecj-12166	56	36	a	a	DET
ecj-12166	56	37	total	total	ADJ
ecj-12166	56	38	cumulative	cumulative	ADJ
ecj-12166	56	39	dose	dose	NOUN
ecj-12166	56	40	of	of	ADP
ecj-12166	56	41	0.6	0.6	NUM
ecj-12166	56	42	mg	mg	PROPN
ecj-12166	56	43	/	/	SYM
ecj-12166	56	44	kg	kg	NOUN
ecj-12166	56	45	intramuscular	intramuscular	ADJ
ecj-12166	56	46	•	•	NUM
ecj-12166	56	47	0.5	0.5	NUM
ecj-12166	56	48	mg	mg	PROPN
ecj-12166	56	49	/	/	SYM
ecj-12166	56	50	kg	kg	PROPN
ecj-12166	56	51	•	•	NOUN
ecj-12166	56	52	may	may	AUX
ecj-12166	56	53	repeat	repeat	VERB
ecj-12166	56	54	0.3	0.3	NUM
ecj-12166	56	55	mg	mg	PROPN
ecj-12166	56	56	/	/	SYM
ecj-12166	56	57	kg	kg	PROPN
ecj-12166	56	58	at	at	ADP
ecj-12166	56	59	45	45	NUM
ecj-12166	56	60	min	min	NOUN
ecj-12166	56	61	intranasal	intranasal	ADJ
ecj-12166	56	62	•	•	NOUN
ecj-12166	56	63	1.5	1.5	NUM
ecj-12166	56	64	mg	mg	NUM
ecj-12166	56	65	/	/	SYM
ecj-12166	56	66	kg	kg	PROPN
ecj-12166	56	67	•	•	NOUN
ecj-12166	56	68	may	may	AUX
ecj-12166	56	69	repeat	repeat	VERB
ecj-12166	56	70	1	1	NUM
ecj-12166	56	71	mg	mg	PROPN
ecj-12166	56	72	/	/	SYM
ecj-12166	56	73	kg	kg	PROPN
ecj-12166	56	74	at	at	ADP
ecj-12166	56	75	20	20	NUM
ecj-12166	56	76	min	min	NOUN
ecj-12166	56	77	•	•	ADP
ecj-12166	56	78	maximum	maximum	PROPN
ecj-12166	56	79	single	single	ADJ
ecj-12166	56	80	dose	dose	NOUN
ecj-12166	56	81	100	100	NUM
ecj-12166	56	82	mg	mg	ADP
ecj-12166	56	83	procedural	procedural	ADJ
ecj-12166	56	84	sedation	sedation	NOUN
ecj-12166	56	85	see	see	VERB
ecj-12166	56	86	adult	adult	NOUN
ecj-12166	56	87	dosing	dosing	NOUN
ecj-12166	56	88	guidelines	guideline	NOUN
ecj-12166	56	89	and	and	CCONJ
ecj-12166	56	90	follow	follow	VERB
ecj-12166	56	91	a	a	DET
ecj-12166	56	92	weight	weight	NOUN
ecj-12166	56	93	-	-	PUNCT
ecj-12166	56	94	based	base	VERB
ecj-12166	56	95	dosing	dose	VERB
ecj-12166	56	96	regimen	regiman	NOUN
ecj-12166	56	97	[	[	X
ecj-12166	56	98	emergency	emergency	NOUN
ecj-12166	56	99	care	care	NOUN
ecj-12166	56	100	journal	journal	PROPN
ecj-12166	56	101	2024	2024	NUM
ecj-12166	56	102	;	;	PUNCT
ecj-12166	57	1	20:12166	20:12166	NUM
ecj-12166	57	2	]	]	X
ecj-12166	58	1	[	[	X
ecj-12166	58	2	page	page	NOUN
ecj-12166	58	3	31	31	NUM
ecj-12166	58	4	]	]	PUNCT
ecj-12166	58	5	non	non	ADJ
ecj-12166	58	6	-co	-co	PROPN
ecj-12166	58	7	mmerc	mmerc	PROPN
ecj-12166	58	8	ial	ial	PROPN
ecj-12166	58	9	us	us	PROPN
ecj-12166	58	10	e	e	NOUN
ecj-12166	58	11	o	o	NOUN
ecj-12166	58	12	nly	nly	ADV
ecj-12166	58	13	patients	patient	NOUN
ecj-12166	58	14	suffering	suffer	VERB
ecj-12166	58	15	from	from	ADP
ecj-12166	58	16	depression,5,6	depression,5,6	NOUN
ecj-12166	58	17	pain,7	pain,7	NOUN
ecj-12166	58	18	status	status	NOUN
ecj-12166	58	19	epilepticus,8	epilepticus,8	X
ecj-12166	58	20	alcoholism,9	alcoholism,9	NOUN
ecj-12166	58	21	and	and	CCONJ
ecj-12166	58	22	substance	substance	NOUN
ecj-12166	58	23	abuse	abuse	NOUN
ecj-12166	58	24	disorders,10	disorders,10	NOUN
ecj-12166	58	25	hyperactive	hyperactive	ADJ
ecj-12166	58	26	delirium	delirium	NOUN
ecj-12166	58	27	with	with	ADP
ecj-12166	58	28	severe	severe	ADJ
ecj-12166	58	29	agitation,11	agitation,11	NOUN
ecj-12166	58	30	but	but	CCONJ
ecj-12166	58	31	it	it	PRON
ecj-12166	58	32	may	may	AUX
ecj-12166	58	33	also	also	ADV
ecj-12166	58	34	be	be	AUX
ecj-12166	58	35	useful	useful	ADJ
ecj-12166	58	36	in	in	ADP
ecj-12166	58	37	treating	treat	VERB
ecj-12166	58	38	severe	severe	ADJ
ecj-12166	58	39	acute	acute	ADJ
ecj-12166	58	40	pain	pain	NOUN
ecj-12166	58	41	in	in	ADP
ecj-12166	58	42	the	the	DET
ecj-12166	58	43	presence	presence	NOUN
ecj-12166	58	44	of	of	ADP
ecj-12166	58	45	hemodynamic	hemodynamic	ADJ
ecj-12166	58	46	instability	instability	NOUN
ecj-12166	58	47	,	,	PUNCT
ecj-12166	58	48	such	such	ADJ
ecj-12166	58	49	as	as	ADP
ecj-12166	58	50	prehospital	prehospital	NOUN
ecj-12166	58	51	trauma,12	trauma,12	NOUN
ecj-12166	58	52	and	and	CCONJ
ecj-12166	58	53	for	for	ADP
ecj-12166	58	54	sedation	sedation	NOUN
ecj-12166	58	55	during	during	ADP
ecj-12166	58	56	non	non	ADJ
ecj-12166	58	57	-	-	ADJ
ecj-12166	58	58	invasive	invasive	ADJ
ecj-12166	58	59	ventilation	ventilation	NOUN
ecj-12166	58	60	alone	alone	ADV
ecj-12166	58	61	or	or	CCONJ
ecj-12166	58	62	combined	combine	VERB
ecj-12166	58	63	with	with	ADP
ecj-12166	58	64	other	other	ADJ
ecj-12166	58	65	drugs.13–16	drugs.13–16	NOUN
ecj-12166	58	66	drug	drug	NOUN
ecj-12166	58	67	characteristics	characteristic	NOUN
ecj-12166	58	68	ketamine	ketamine	PROPN
ecj-12166	58	69	is	be	AUX
ecj-12166	58	70	a	a	DET
ecj-12166	58	71	highly	highly	ADV
ecj-12166	58	72	lipophilic	lipophilic	ADJ
ecj-12166	58	73	drug	drug	NOUN
ecj-12166	58	74	with	with	ADP
ecj-12166	58	75	a	a	DET
ecj-12166	58	76	rapid	rapid	ADJ
ecj-12166	58	77	and	and	CCONJ
ecj-12166	58	78	large	large	ADJ
ecj-12166	58	79	steady	steady	ADJ
ecj-12166	58	80	-	-	PUNCT
ecj-12166	58	81	state	state	NOUN
ecj-12166	58	82	volume	volume	NOUN
ecj-12166	58	83	of	of	ADP
ecj-12166	58	84	distribution.1,17	distribution.1,17	NOUN
ecj-12166	58	85	acting	act	VERB
ecj-12166	58	86	as	as	ADP
ecj-12166	58	87	an	an	DET
ecj-12166	58	88	antagonist	antagonist	NOUN
ecj-12166	58	89	on	on	ADP
ecj-12166	58	90	nmda	nmda	ADJ
ecj-12166	58	91	receptors	receptor	NOUN
ecj-12166	58	92	,	,	PUNCT
ecj-12166	58	93	it	it	PRON
ecj-12166	58	94	can	can	AUX
ecj-12166	58	95	reverse	reverse	VERB
ecj-12166	58	96	the	the	DET
ecj-12166	58	97	enhanced	enhanced	ADJ
ecj-12166	58	98	pain	pain	NOUN
ecj-12166	58	99	sensitivity	sensitivity	NOUN
ecj-12166	58	100	that	that	PRON
ecj-12166	58	101	is	be	AUX
ecj-12166	58	102	frequently	frequently	ADV
ecj-12166	58	103	present	present	ADJ
ecj-12166	58	104	in	in	ADP
ecj-12166	58	105	major	major	ADJ
ecj-12166	58	106	trauma	trauma	NOUN
ecj-12166	58	107	or	or	CCONJ
ecj-12166	58	108	surgical	surgical	ADJ
ecj-12166	58	109	injury	injury	NOUN
ecj-12166	58	110	and	and	CCONJ
ecj-12166	58	111	increases	increase	VERB
ecj-12166	58	112	the	the	DET
ecj-12166	58	113	anti	anti	ADJ
ecj-12166	58	114	-	-	ADJ
ecj-12166	58	115	nociceptive	nociceptive	ADJ
ecj-12166	58	116	effects	effect	NOUN
ecj-12166	58	117	of	of	ADP
ecj-12166	58	118	conventional	conventional	ADJ
ecj-12166	58	119	opioid	opioid	NOUN
ecj-12166	58	120	and	and	CCONJ
ecj-12166	58	121	nonsteroidal	nonsteroidal	ADJ
ecj-12166	58	122	anti	anti	ADJ
ecj-12166	58	123	-	-	ADJ
ecj-12166	58	124	inflammatory	inflammatory	ADJ
ecj-12166	58	125	drugs	drug	NOUN
ecj-12166	58	126	,	,	PUNCT
ecj-12166	58	127	but	but	CCONJ
ecj-12166	58	128	ketamine	ketamine	PROPN
ecj-12166	58	129	can	can	AUX
ecj-12166	58	130	also	also	ADV
ecj-12166	58	131	interact	interact	VERB
ecj-12166	58	132	with	with	ADP
ecj-12166	58	133	several	several	ADJ
ecj-12166	58	134	other	other	ADJ
ecj-12166	58	135	receptors	receptor	NOUN
ecj-12166	58	136	,	,	PUNCT
ecj-12166	58	137	including	include	VERB
ecj-12166	58	138	μ	μ	NUM
ecj-12166	58	139	,	,	PUNCT
ecj-12166	58	140	κ	κ	PROPN
ecj-12166	58	141	and	and	CCONJ
ecj-12166	58	142	δ	δ	PROPN
ecj-12166	58	143	opioid	opioid	ADJ
ecj-12166	58	144	receptors	receptor	NOUN
ecj-12166	58	145	,	,	PUNCT
ecj-12166	58	146	that	that	PRON
ecj-12166	58	147	contributes	contribute	VERB
ecj-12166	58	148	to	to	ADP
ecj-12166	58	149	its	its	PRON
ecj-12166	58	150	analgesic	analgesic	ADJ
ecj-12166	58	151	effects	effect	NOUN
ecj-12166	58	152	.	.	PUNCT
ecj-12166	59	1	in	in	ADP
ecj-12166	59	2	addition	addition	NOUN
ecj-12166	59	3	,	,	PUNCT
ecj-12166	59	4	ketamine	ketamine	PROPN
ecj-12166	59	5	can	can	AUX
ecj-12166	59	6	inhibit	inhibit	VERB
ecj-12166	59	7	muscarinic	muscarinic	ADJ
ecj-12166	59	8	and	and	CCONJ
ecj-12166	59	9	nicotinic	nicotinic	ADJ
ecj-12166	59	10	receptors	receptor	NOUN
ecj-12166	59	11	,	,	PUNCT
ecj-12166	59	12	l	l	NOUN
ecj-12166	59	13	-	-	PUNCT
ecj-12166	59	14	type	type	NOUN
ecj-12166	59	15	calcium	calcium	NOUN
ecj-12166	59	16	and	and	CCONJ
ecj-12166	59	17	sodium	sodium	NOUN
ecj-12166	59	18	channels	channel	NOUN
ecj-12166	59	19	current	current	ADJ
ecj-12166	59	20	,	,	PUNCT
ecj-12166	59	21	adrenergic	adrenergic	ADJ
ecj-12166	59	22	and	and	CCONJ
ecj-12166	59	23	serotonin	serotonin	NOUN
ecj-12166	59	24	receptors	receptor	NOUN
ecj-12166	59	25	,	,	PUNCT
ecj-12166	59	26	and	and	CCONJ
ecj-12166	59	27	dopaminergic	dopaminergic	ADJ
ecj-12166	59	28	d2	d2	NOUN
ecj-12166	59	29	receptors,1	receptors,1	NOUN
ecj-12166	59	30	and	and	CCONJ
ecj-12166	59	31	it	it	PRON
ecj-12166	59	32	can	can	AUX
ecj-12166	59	33	have	have	VERB
ecj-12166	59	34	anti	anti	ADJ
ecj-12166	59	35	-	-	ADJ
ecj-12166	59	36	inflammatory	inflammatory	ADJ
ecj-12166	59	37	effects	effect	NOUN
ecj-12166	59	38	by	by	ADP
ecj-12166	59	39	decreasing	decrease	VERB
ecj-12166	59	40	il-6	il-6	NUM
ecj-12166	59	41	,	,	PUNCT
ecj-12166	59	42	tnf	tnf	PROPN
ecj-12166	59	43	alpha	alpha	PROPN
ecj-12166	59	44	,	,	PUNCT
ecj-12166	59	45	crp	crp	PROPN
ecj-12166	59	46	,	,	PUNCT
ecj-12166	59	47	and	and	CCONJ
ecj-12166	59	48	no	no	DET
ecj-12166	59	49	synthase	synthase	NOUN
ecj-12166	59	50	levels	level	NOUN
ecj-12166	59	51	,	,	PUNCT
ecj-12166	59	52	particularly	particularly	ADV
ecj-12166	59	53	in	in	ADP
ecj-12166	59	54	the	the	DET
ecj-12166	59	55	post	post	ADJ
ecj-12166	59	56	-	-	ADJ
ecj-12166	59	57	operative	operative	ADJ
ecj-12166	59	58	setting.2	setting.2	PROPN
ecj-12166	59	59	metabolism	metabolism	NOUN
ecj-12166	59	60	ketamine	ketamine	PROPN
ecj-12166	59	61	undergoes	undergo	VERB
ecj-12166	59	62	liver	liver	NOUN
ecj-12166	59	63	metabolism	metabolism	NOUN
ecj-12166	59	64	via	via	ADP
ecj-12166	59	65	the	the	DET
ecj-12166	59	66	cytochromes	cytochrome	NOUN
ecj-12166	59	67	cyp2b6	cyp2b6	NOUN
ecj-12166	59	68	and	and	CCONJ
ecj-12166	59	69	cyp3a4	cyp3a4	NOUN
ecj-12166	59	70	,	,	PUNCT
ecj-12166	59	71	producing	produce	VERB
ecj-12166	59	72	the	the	DET
ecj-12166	59	73	active	active	ADJ
ecj-12166	59	74	metabolite	metabolite	NOUN
ecj-12166	59	75	(	(	PUNCT
ecj-12166	59	76	r	r	NOUN
ecj-12166	59	77	,	,	PUNCT
ecj-12166	59	78	s)norketamine	s)norketamine	NOUN
ecj-12166	59	79	,	,	PUNCT
ecj-12166	59	80	which	which	PRON
ecj-12166	59	81	has	have	VERB
ecj-12166	59	82	psychoactive	psychoactive	ADJ
ecj-12166	59	83	properties	property	NOUN
ecj-12166	59	84	and	and	CCONJ
ecj-12166	59	85	anesthetic	anesthetic	ADJ
ecj-12166	59	86	effects	effect	NOUN
ecj-12166	59	87	.	.	PUNCT
ecj-12166	60	1	the	the	DET
ecj-12166	60	2	major	major	ADJ
ecj-12166	60	3	metabolic	metabolic	NOUN
ecj-12166	60	4	pathway	pathway	NOUN
ecj-12166	60	5	is	be	AUX
ecj-12166	60	6	n	n	NOUN
ecj-12166	60	7	-	-	PUNCT
ecj-12166	60	8	demethylation	demethylation	NOUN
ecj-12166	60	9	.	.	PUNCT
ecj-12166	61	1	depending	depend	VERB
ecj-12166	61	2	on	on	ADP
ecj-12166	61	3	the	the	DET
ecj-12166	61	4	expression	expression	NOUN
ecj-12166	61	5	of	of	ADP
ecj-12166	61	6	p450	p450	PROPN
ecj-12166	61	7	enzymes,18,19	enzymes,18,19	NOUN
ecj-12166	61	8	the	the	DET
ecj-12166	61	9	metabolism	metabolism	NOUN
ecj-12166	61	10	of	of	ADP
ecj-12166	61	11	ketamine	ketamine	PROPN
ecj-12166	61	12	varies	vary	VERB
ecj-12166	61	13	individually	individually	ADV
ecj-12166	61	14	.	.	PUNCT
ecj-12166	62	1	absorption	absorption	NOUN
ecj-12166	62	2	,	,	PUNCT
ecj-12166	62	3	distribution	distribution	NOUN
ecj-12166	62	4	,	,	PUNCT
ecj-12166	62	5	and	and	CCONJ
ecj-12166	62	6	excretion	excretion	NOUN
ecj-12166	62	7	after	after	ADP
ecj-12166	62	8	being	be	AUX
ecj-12166	62	9	metabolized	metabolize	VERB
ecj-12166	62	10	in	in	ADP
ecj-12166	62	11	the	the	DET
ecj-12166	62	12	liver	liver	NOUN
ecj-12166	62	13	,	,	PUNCT
ecj-12166	62	14	ketamine	ketamine	PROPN
ecj-12166	62	15	is	be	AUX
ecj-12166	62	16	rapidly	rapidly	ADV
ecj-12166	62	17	distributed	distribute	VERB
ecj-12166	62	18	into	into	ADP
ecj-12166	62	19	highly	highly	ADV
ecj-12166	62	20	perfused	perfuse	VERB
ecj-12166	62	21	tissues	tissue	NOUN
ecj-12166	62	22	with	with	ADP
ecj-12166	62	23	an	an	DET
ecj-12166	62	24	immediate	immediate	ADJ
ecj-12166	62	25	passage	passage	NOUN
ecj-12166	62	26	through	through	ADP
ecj-12166	62	27	the	the	DET
ecj-12166	62	28	central	central	ADJ
ecj-12166	62	29	nervous	nervous	ADJ
ecj-12166	62	30	system,20,21	system,20,21	NOUN
ecj-12166	62	31	crossing	cross	VERB
ecj-12166	62	32	the	the	DET
ecj-12166	62	33	blood	blood	NOUN
ecj-12166	62	34	-	-	PUNCT
ecj-12166	62	35	brain	brain	NOUN
ecj-12166	62	36	barrier	barrier	NOUN
ecj-12166	62	37	.	.	PUNCT
ecj-12166	63	1	since	since	SCONJ
ecj-12166	63	2	ketamine	ketamine	PROPN
ecj-12166	63	3	is	be	AUX
ecj-12166	63	4	very	very	ADV
ecj-12166	63	5	lipid	lipid	NOUN
ecj-12166	63	6	-	-	PUNCT
ecj-12166	63	7	soluble	soluble	ADJ
ecj-12166	63	8	and	and	CCONJ
ecj-12166	63	9	has	have	VERB
ecj-12166	63	10	a	a	DET
ecj-12166	63	11	relatively	relatively	ADV
ecj-12166	63	12	low	low	ADJ
ecj-12166	63	13	protein	protein	NOUN
ecj-12166	63	14	binding	bind	VERB
ecj-12166	63	15	(	(	PUNCT
ecj-12166	63	16	ranging	range	VERB
ecj-12166	63	17	from	from	ADP
ecj-12166	63	18	10	10	NUM
ecj-12166	63	19	%	%	NOUN
ecj-12166	63	20	to	to	ADP
ecj-12166	63	21	50%),22	50%),22	NOUN
ecj-12166	63	22	it	it	PRON
ecj-12166	63	23	has	have	VERB
ecj-12166	63	24	a	a	DET
ecj-12166	63	25	large	large	ADJ
ecj-12166	63	26	volume	volume	NOUN
ecj-12166	63	27	of	of	ADP
ecj-12166	63	28	distribution	distribution	NOUN
ecj-12166	63	29	(	(	PUNCT
ecj-12166	63	30	3	3	NUM
ecj-12166	63	31	-	-	SYM
ecj-12166	63	32	5	5	NUM
ecj-12166	63	33	l	l	NOUN
ecj-12166	63	34	/	/	SYM
ecj-12166	63	35	kg	kg	NOUN
ecj-12166	63	36	)	)	PUNCT
ecj-12166	63	37	.	.	PUNCT
ecj-12166	64	1	ketamine	ketamine	PROPN
ecj-12166	64	2	has	have	VERB
ecj-12166	64	3	a	a	DET
ecj-12166	64	4	faster	fast	ADJ
ecj-12166	64	5	onset	onset	NOUN
ecj-12166	64	6	of	of	ADP
ecj-12166	64	7	action	action	NOUN
ecj-12166	64	8	but	but	CCONJ
ecj-12166	64	9	a	a	DET
ecj-12166	64	10	shorter	short	ADJ
ecj-12166	64	11	half	half	ADJ
ecj-12166	64	12	-	-	PUNCT
ecj-12166	64	13	life:2,20	life:2,20	VERB
ecj-12166	64	14	its	its	PRON
ecj-12166	64	15	onset	onset	NOUN
ecj-12166	64	16	of	of	ADP
ecj-12166	64	17	action	action	NOUN
ecj-12166	64	18	is	be	AUX
ecj-12166	64	19	2	2	NUM
ecj-12166	64	20	-	-	SYM
ecj-12166	64	21	3	3	NUM
ecj-12166	64	22	min	min	NOUN
ecj-12166	64	23	,	,	PUNCT
ecj-12166	64	24	with	with	ADP
ecj-12166	64	25	a	a	DET
ecj-12166	64	26	duration	duration	NOUN
ecj-12166	64	27	of	of	ADP
ecj-12166	64	28	effect	effect	NOUN
ecj-12166	64	29	ranging	range	VERB
ecj-12166	64	30	from	from	ADP
ecj-12166	64	31	5	5	NUM
ecj-12166	64	32	-	-	SYM
ecj-12166	64	33	30	30	NUM
ecj-12166	64	34	minutes.23	minutes.23	PROPN
ecj-12166	64	35	therefore	therefore	ADV
ecj-12166	64	36	,	,	PUNCT
ecj-12166	64	37	for	for	ADP
ecj-12166	64	38	prolonged	prolonged	ADJ
ecj-12166	64	39	activity	activity	NOUN
ecj-12166	64	40	sometimes	sometimes	ADV
ecj-12166	64	41	continuous	continuous	ADJ
ecj-12166	64	42	infusions	infusion	NOUN
ecj-12166	64	43	may	may	AUX
ecj-12166	64	44	be	be	AUX
ecj-12166	64	45	required	require	VERB
ecj-12166	64	46	.	.	PUNCT
ecj-12166	65	1	due	due	ADP
ecj-12166	65	2	to	to	ADP
ecj-12166	65	3	its	its	PRON
ecj-12166	65	4	quick	quick	ADJ
ecj-12166	65	5	onset	onset	NOUN
ecj-12166	65	6	and	and	CCONJ
ecj-12166	65	7	short	short	ADJ
ecj-12166	65	8	duration	duration	NOUN
ecj-12166	65	9	of	of	ADP
ecj-12166	65	10	action	action	NOUN
ecj-12166	65	11	with	with	ADP
ecj-12166	65	12	only	only	ADJ
ecj-12166	65	13	slight	slight	ADJ
ecj-12166	65	14	cardio	cardio	ADJ
ecj-12166	65	15	-	-	PUNCT
ecj-12166	65	16	respiratory	respiratory	ADJ
ecj-12166	65	17	depression	depression	NOUN
ecj-12166	65	18	,	,	PUNCT
ecj-12166	65	19	ketamine	ketamine	PROPN
ecj-12166	65	20	is	be	AUX
ecj-12166	65	21	a	a	DET
ecj-12166	65	22	preferred	preferred	ADJ
ecj-12166	65	23	drug	drug	NOUN
ecj-12166	65	24	for	for	ADP
ecj-12166	65	25	short	short	ADJ
ecj-12166	65	26	-	-	PUNCT
ecj-12166	65	27	term	term	NOUN
ecj-12166	65	28	surgical	surgical	ADJ
ecj-12166	65	29	procedures	procedure	NOUN
ecj-12166	65	30	,	,	PUNCT
ecj-12166	65	31	especially	especially	ADV
ecj-12166	65	32	in	in	ADP
ecj-12166	65	33	children.24	children.24	NOUN
ecj-12166	65	34	duration	duration	NOUN
ecj-12166	65	35	of	of	ADP
ecj-12166	65	36	action	action	NOUN
ecj-12166	65	37	and	and	CCONJ
ecj-12166	65	38	bioavailability	bioavailability	NOUN
ecj-12166	65	39	may	may	AUX
ecj-12166	65	40	vary	vary	VERB
ecj-12166	65	41	depending	depend	VERB
ecj-12166	65	42	on	on	ADP
ecj-12166	65	43	the	the	DET
ecj-12166	65	44	route	route	NOUN
ecj-12166	65	45	of	of	ADP
ecj-12166	65	46	administration.25	administration.25	PROPN
ecj-12166	65	47	ketamine	ketamine	PROPN
ecj-12166	65	48	can	can	AUX
ecj-12166	65	49	be	be	AUX
ecj-12166	65	50	administered	administer	VERB
ecj-12166	65	51	via	via	ADP
ecj-12166	65	52	almost	almost	ADV
ecj-12166	65	53	any	any	PRON
ecj-12166	65	54	route	route	NOUN
ecj-12166	65	55	depending	depend	VERB
ecj-12166	65	56	on	on	ADP
ecj-12166	65	57	the	the	DET
ecj-12166	65	58	intent	intent	NOUN
ecj-12166	65	59	.	.	PUNCT
ecj-12166	66	1	bioavailability	bioavailability	NOUN
ecj-12166	66	2	largely	largely	ADV
ecj-12166	66	3	depends	depend	VERB
ecj-12166	66	4	on	on	ADP
ecj-12166	66	5	the	the	DET
ecj-12166	66	6	route	route	NOUN
ecj-12166	66	7	of	of	ADP
ecj-12166	66	8	administration.1	administration.1	PROPN
ecj-12166	66	9	it	it	PRON
ecj-12166	66	10	showed	show	VERB
ecj-12166	66	11	a	a	DET
ecj-12166	66	12	limited	limited	ADJ
ecj-12166	66	13	bioavailability	bioavailability	NOUN
ecj-12166	66	14	after	after	ADP
ecj-12166	66	15	oral	oral	ADJ
ecj-12166	66	16	,	,	PUNCT
ecj-12166	66	17	sublingual	sublingual	ADJ
ecj-12166	66	18	,	,	PUNCT
ecj-12166	66	19	and	and	CCONJ
ecj-12166	66	20	rectal	rectal	ADJ
ecj-12166	66	21	administration	administration	NOUN
ecj-12166	66	22	,	,	PUNCT
ecj-12166	66	23	because	because	SCONJ
ecj-12166	66	24	of	of	ADP
ecj-12166	66	25	the	the	DET
ecj-12166	66	26	first	first	ADJ
ecj-12166	66	27	-	-	PUNCT
ecj-12166	66	28	pass	pass	NOUN
ecj-12166	66	29	effect.26	effect.26	NOUN
ecj-12166	66	30	after	after	ADP
ecj-12166	66	31	oral	oral	ADJ
ecj-12166	66	32	administration	administration	NOUN
ecj-12166	66	33	,	,	PUNCT
ecj-12166	66	34	bioavailability	bioavailability	NOUN
ecj-12166	66	35	is	be	AUX
ecj-12166	66	36	16	16	NUM
ecj-12166	66	37	-	-	SYM
ecj-12166	66	38	29	29	NUM
ecj-12166	66	39	%	%	NOUN
ecj-12166	66	40	,	,	PUNCT
ecj-12166	66	41	the	the	DET
ecj-12166	66	42	action	action	NOUN
ecj-12166	66	43	onset	onset	NOUN
ecj-12166	66	44	typically	typically	ADV
ecj-12166	66	45	occurs	occur	VERB
ecj-12166	66	46	within	within	ADP
ecj-12166	66	47	20	20	NUM
ecj-12166	66	48	-	-	SYM
ecj-12166	66	49	30	30	NUM
ecj-12166	66	50	min	min	NOUN
ecj-12166	66	51	,	,	PUNCT
ecj-12166	66	52	and	and	CCONJ
ecj-12166	66	53	the	the	DET
ecj-12166	66	54	duration	duration	NOUN
ecj-12166	66	55	of	of	ADP
ecj-12166	66	56	effect	effect	NOUN
ecj-12166	66	57	is	be	AUX
ecj-12166	66	58	between	between	ADP
ecj-12166	66	59	60	60	NUM
ecj-12166	66	60	and	and	CCONJ
ecj-12166	66	61	90	90	NUM
ecj-12166	66	62	min	min	NOUN
ecj-12166	66	63	.	.	PUNCT
ecj-12166	67	1	the	the	DET
ecj-12166	67	2	most	most	ADV
ecj-12166	67	3	common	common	ADJ
ecj-12166	67	4	routes	route	NOUN
ecj-12166	67	5	of	of	ADP
ecj-12166	67	6	administration	administration	NOUN
ecj-12166	67	7	are	be	AUX
ecj-12166	67	8	intravenous	intravenous	ADJ
ecj-12166	67	9	(	(	PUNCT
ecj-12166	67	10	iv	iv	NUM
ecj-12166	67	11	)	)	PUNCT
ecj-12166	67	12	and	and	CCONJ
ecj-12166	67	13	intramuscular	intramuscular	ADJ
ecj-12166	67	14	(	(	PUNCT
ecj-12166	67	15	im)27	im)27	PROPN
ecj-12166	67	16	with	with	ADP
ecj-12166	67	17	bioavailability	bioavailability	NOUN
ecj-12166	67	18	higher	high	ADJ
ecj-12166	67	19	and	and	CCONJ
ecj-12166	67	20	rapid	rapid	ADJ
ecj-12166	67	21	achievement	achievement	NOUN
ecj-12166	67	22	of	of	ADP
ecj-12166	67	23	maximum	maximum	ADJ
ecj-12166	67	24	plasma	plasma	NOUN
ecj-12166	67	25	concentrations.28	concentrations.28	NOUN
ecj-12166	67	26	when	when	SCONJ
ecj-12166	67	27	administered	administer	VERB
ecj-12166	67	28	intravenously	intravenously	ADV
ecj-12166	67	29	,	,	PUNCT
ecj-12166	67	30	the	the	DET
ecj-12166	67	31	bioavailability	bioavailability	NOUN
ecj-12166	67	32	is	be	AUX
ecj-12166	67	33	100	100	NUM
ecj-12166	67	34	%	%	NOUN
ecj-12166	67	35	and	and	CCONJ
ecj-12166	67	36	the	the	DET
ecj-12166	67	37	onset	onset	NOUN
ecj-12166	67	38	of	of	ADP
ecj-12166	67	39	action	action	NOUN
ecj-12166	67	40	typically	typically	ADV
ecj-12166	67	41	occurs	occur	VERB
ecj-12166	67	42	within	within	ADP
ecj-12166	67	43	1	1	NUM
ecj-12166	67	44	-	-	SYM
ecj-12166	67	45	2	2	NUM
ecj-12166	67	46	min	min	NOUN
ecj-12166	67	47	,	,	PUNCT
ecj-12166	67	48	and	and	CCONJ
ecj-12166	67	49	anesthesia	anesthesia	PROPN
ecj-12166	67	50	lasts	last	VERB
ecj-12166	67	51	for	for	ADP
ecj-12166	67	52	approximately	approximately	ADV
ecj-12166	67	53	20	20	NUM
ecj-12166	67	54	-	-	SYM
ecj-12166	67	55	60	60	NUM
ecj-12166	67	56	min	min	NOUN
ecj-12166	67	57	.	.	PROPN
ecj-12166	67	58	after	after	SCONJ
ecj-12166	67	59	i	i	PRON
ecj-12166	67	60	m	m	VERB
ecj-12166	67	61	injection	injection	NOUN
ecj-12166	67	62	,	,	PUNCT
ecj-12166	67	63	bioavailability	bioavailability	NOUN
ecj-12166	67	64	is	be	AUX
ecj-12166	67	65	93	93	NUM
ecj-12166	67	66	%	%	NOUN
ecj-12166	67	67	,	,	PUNCT
ecj-12166	67	68	and	and	CCONJ
ecj-12166	67	69	maximum	maximum	ADJ
ecj-12166	67	70	effect	effect	NOUN
ecj-12166	67	71	is	be	AUX
ecj-12166	67	72	achieved	achieve	VERB
ecj-12166	67	73	within	within	ADP
ecj-12166	67	74	5	5	NUM
ecj-12166	67	75	-	-	SYM
ecj-12166	67	76	10	10	NUM
ecj-12166	67	77	min	min	NOUN
ecj-12166	67	78	and	and	CCONJ
ecj-12166	67	79	typically	typically	ADV
ecj-12166	67	80	lasts	last	VERB
ecj-12166	67	81	for	for	ADP
ecj-12166	67	82	30	30	NUM
ecj-12166	67	83	-	-	SYM
ecj-12166	67	84	120	120	NUM
ecj-12166	67	85	min	min	NOUN
ecj-12166	67	86	.	.	PUNCT
ecj-12166	68	1	i	i	PRON
ecj-12166	68	2	m	m	PROPN
ecj-12166	68	3	administration	administration	NOUN
ecj-12166	68	4	is	be	AUX
ecj-12166	68	5	used	use	VERB
ecj-12166	68	6	in	in	ADP
ecj-12166	68	7	emergency	emergency	NOUN
ecj-12166	68	8	cases	case	NOUN
ecj-12166	68	9	of	of	ADP
ecj-12166	68	10	uncooperative	uncooperative	ADJ
ecj-12166	68	11	and	and	CCONJ
ecj-12166	68	12	agitated	agitated	ADJ
ecj-12166	68	13	patients	patient	NOUN
ecj-12166	68	14	and	and	CCONJ
ecj-12166	68	15	neonates	neonate	NOUN
ecj-12166	68	16	,	,	PUNCT
ecj-12166	68	17	even	even	ADV
ecj-12166	68	18	if	if	SCONJ
ecj-12166	68	19	intranasal	intranasal	ADJ
ecj-12166	68	20	(	(	PUNCT
ecj-12166	68	21	in	in	ADP
ecj-12166	68	22	)	)	PUNCT
ecj-12166	68	23	is	be	AUX
ecj-12166	68	24	less	less	ADV
ecj-12166	68	25	invasive	invasive	ADJ
ecj-12166	68	26	in	in	ADP
ecj-12166	68	27	children	child	NOUN
ecj-12166	68	28	and	and	CCONJ
ecj-12166	68	29	easier	easy	ADJ
ecj-12166	68	30	in	in	ADP
ecj-12166	68	31	critically	critically	ADV
ecj-12166	68	32	ill	ill	ADJ
ecj-12166	68	33	patients.29	patients.29	NOUN
ecj-12166	68	34	in	in	ADP
ecj-12166	68	35	administration	administration	NOUN
ecj-12166	68	36	for	for	ADP
ecj-12166	68	37	analgesic	analgesic	ADJ
ecj-12166	68	38	purposes	purpose	NOUN
ecj-12166	68	39	is	be	AUX
ecj-12166	68	40	a	a	DET
ecj-12166	68	41	good	good	ADJ
ecj-12166	68	42	alternative	alternative	NOUN
ecj-12166	68	43	to	to	ADP
ecj-12166	68	44	iv	iv	NUM
ecj-12166	68	45	administration	administration	NOUN
ecj-12166	68	46	for	for	ADP
ecj-12166	68	47	its	its	PRON
ecj-12166	68	48	rapid	rapid	ADJ
ecj-12166	68	49	systemic	systemic	ADJ
ecj-12166	68	50	absorption	absorption	NOUN
ecj-12166	68	51	and	and	CCONJ
ecj-12166	68	52	because	because	SCONJ
ecj-12166	68	53	it	it	PRON
ecj-12166	68	54	bypasses	bypass	VERB
ecj-12166	68	55	first	first	ADJ
ecj-12166	68	56	-	-	PUNCT
ecj-12166	68	57	pass	pass	VERB
ecj-12166	68	58	hepatic	hepatic	ADJ
ecj-12166	68	59	metabolism,30	metabolism,30	NOUN
ecj-12166	68	60	especially	especially	ADV
ecj-12166	68	61	in	in	ADP
ecj-12166	68	62	children.6,31	children.6,31	PROPN
ecj-12166	68	63	in	in	ADP
ecj-12166	68	64	administration	administration	NOUN
ecj-12166	68	65	shows	show	VERB
ecj-12166	68	66	a	a	DET
ecj-12166	68	67	bioavailability	bioavailability	NOUN
ecj-12166	68	68	of	of	ADP
ecj-12166	68	69	35	35	NUM
ecj-12166	68	70	-	-	SYM
ecj-12166	68	71	50	50	NUM
ecj-12166	68	72	%	%	NOUN
ecj-12166	68	73	,	,	PUNCT
ecj-12166	68	74	an	an	DET
ecj-12166	68	75	analgesic	analgesic	ADJ
ecj-12166	68	76	effect	effect	NOUN
ecj-12166	68	77	with	with	ADP
ecj-12166	68	78	the	the	DET
ecj-12166	68	79	onset	onset	NOUN
ecj-12166	68	80	of	of	ADP
ecj-12166	68	81	action	action	NOUN
ecj-12166	68	82	within	within	ADP
ecj-12166	68	83	10	10	NUM
ecj-12166	68	84	min	min	NOUN
ecj-12166	68	85	,	,	PUNCT
ecj-12166	68	86	a	a	DET
ecj-12166	68	87	timeto	timeto	NOUN
ecj-12166	68	88	-	-	PUNCT
ecj-12166	68	89	peak	peak	NOUN
ecj-12166	68	90	effect	effect	NOUN
ecj-12166	68	91	of	of	ADP
ecj-12166	68	92	10	10	NUM
ecj-12166	68	93	-	-	SYM
ecj-12166	68	94	14	14	NUM
ecj-12166	68	95	min	min	NOUN
ecj-12166	68	96	,	,	PUNCT
ecj-12166	68	97	and	and	CCONJ
ecj-12166	68	98	a	a	DET
ecj-12166	68	99	duration	duration	NOUN
ecj-12166	68	100	of	of	ADP
ecj-12166	68	101	up	up	ADP
ecj-12166	68	102	to	to	PART
ecj-12166	68	103	60	60	NUM
ecj-12166	68	104	min.2	min.2	PROPN
ecj-12166	68	105	elimination	elimination	NOUN
ecj-12166	68	106	of	of	ADP
ecj-12166	68	107	ketamine	ketamine	PROPN
ecj-12166	68	108	and	and	CCONJ
ecj-12166	68	109	metabolites	metabolite	NOUN
ecj-12166	68	110	is	be	AUX
ecj-12166	68	111	performed	perform	VERB
ecj-12166	68	112	by	by	ADP
ecj-12166	68	113	the	the	DET
ecj-12166	68	114	kidneys,17	kidneys,17	ADJ
ecj-12166	68	115	thorough	thorough	NOUN
ecj-12166	68	116	the	the	DET
ecj-12166	68	117	conversion	conversion	NOUN
ecj-12166	68	118	of	of	ADP
ecj-12166	68	119	ketamine	ketamine	PROPN
ecj-12166	68	120	and	and	CCONJ
ecj-12166	68	121	norketamine	norketamine	VERB
ecj-12166	68	122	to	to	ADP
ecj-12166	68	123	6	6	NUM
ecj-12166	68	124	-	-	PUNCT
ecj-12166	68	125	hydroxynorketamine	hydroxynorketamine	NOUN
ecj-12166	68	126	and	and	CCONJ
ecj-12166	68	127	5,6	5,6	NUM
ecj-12166	68	128	-	-	PUNCT
ecj-12166	68	129	dehydronorketamine,18,32	dehydronorketamine,18,32	VERB
ecj-12166	68	130	both	both	CCONJ
ecj-12166	68	131	inactive	inactive	ADJ
ecj-12166	68	132	free	free	ADJ
ecj-12166	68	133	and	and	CCONJ
ecj-12166	68	134	glucuronidated	glucuronidate	VERB
ecj-12166	68	135	hydroxylated	hydroxylated	ADJ
ecj-12166	68	136	derivatives	derivative	NOUN
ecj-12166	68	137	,	,	PUNCT
ecj-12166	68	138	which	which	PRON
ecj-12166	68	139	are	be	AUX
ecj-12166	68	140	more	more	ADJ
ecj-12166	68	141	water	water	NOUN
ecj-12166	68	142	-	-	PUNCT
ecj-12166	68	143	soluble	soluble	ADJ
ecj-12166	68	144	compounds	compound	NOUN
ecj-12166	68	145	to	to	PART
ecj-12166	68	146	facilitate	facilitate	VERB
ecj-12166	68	147	urinary	urinary	ADJ
ecj-12166	68	148	excretion	excretion	NOUN
ecj-12166	68	149	.	.	PUNCT
ecj-12166	69	1	due	due	ADP
ecj-12166	69	2	to	to	ADP
ecj-12166	69	3	its	its	PRON
ecj-12166	69	4	shorter	short	ADJ
ecj-12166	69	5	half	half	ADJ
ecj-12166	69	6	-	-	PUNCT
ecj-12166	69	7	life	life	NOUN
ecj-12166	69	8	,	,	PUNCT
ecj-12166	69	9	no	no	DET
ecj-12166	69	10	dosage	dosage	NOUN
ecj-12166	69	11	adjustment	adjustment	NOUN
ecj-12166	69	12	is	be	AUX
ecj-12166	69	13	required	require	VERB
ecj-12166	69	14	for	for	ADP
ecj-12166	69	15	patients	patient	NOUN
ecj-12166	69	16	with	with	ADP
ecj-12166	69	17	impaired	impaired	ADJ
ecj-12166	69	18	renal	renal	ADJ
ecj-12166	69	19	function.33	function.33	NOUN
ecj-12166	69	20	clinical	clinical	ADJ
ecj-12166	69	21	settings	setting	NOUN
ecj-12166	69	22	in	in	ADP
ecj-12166	69	23	the	the	DET
ecj-12166	69	24	pre	pre	ADJ
ecj-12166	69	25	-	-	ADJ
ecj-12166	69	26	hospital	hospital	ADJ
ecj-12166	69	27	setting	setting	NOUN
ecj-12166	69	28	,	,	PUNCT
ecj-12166	69	29	ketamine	ketamine	PROPN
ecj-12166	69	30	is	be	AUX
ecj-12166	69	31	particularly	particularly	ADV
ecj-12166	69	32	effective	effective	ADJ
ecj-12166	69	33	in	in	ADP
ecj-12166	69	34	the	the	DET
ecj-12166	69	35	treatment	treatment	NOUN
ecj-12166	69	36	of	of	ADP
ecj-12166	69	37	trauma	trauma	NOUN
ecj-12166	69	38	patients	patient	NOUN
ecj-12166	69	39	who	who	PRON
ecj-12166	69	40	have	have	VERB
ecj-12166	69	41	hemodynamic	hemodynamic	ADJ
ecj-12166	69	42	instability	instability	NOUN
ecj-12166	69	43	or	or	CCONJ
ecj-12166	69	44	head	head	NOUN
ecj-12166	69	45	injuries	injury	NOUN
ecj-12166	69	46	because	because	SCONJ
ecj-12166	69	47	of	of	ADP
ecj-12166	69	48	its	its	PRON
ecj-12166	69	49	favorable	favorable	ADJ
ecj-12166	69	50	cardiovascular	cardiovascular	ADJ
ecj-12166	69	51	characteristics	characteristic	NOUN
ecj-12166	69	52	of	of	ADP
ecj-12166	69	53	stimulating	stimulate	VERB
ecj-12166	69	54	the	the	DET
ecj-12166	69	55	central	central	ADJ
ecj-12166	69	56	sympathetic	sympathetic	ADJ
ecj-12166	69	57	system	system	NOUN
ecj-12166	69	58	and	and	CCONJ
ecj-12166	69	59	inhibiting	inhibit	VERB
ecj-12166	69	60	neuronal	neuronal	ADJ
ecj-12166	69	61	catecholamine	catecholamine	NOUN
ecj-12166	69	62	uptake,20	uptake,20	NOUN
ecj-12166	69	63	increasing	increase	VERB
ecj-12166	69	64	blood	blood	NOUN
ecj-12166	69	65	pressure	pressure	NOUN
ecj-12166	69	66	and	and	CCONJ
ecj-12166	69	67	cardiac	cardiac	ADJ
ecj-12166	69	68	rate	rate	NOUN
ecj-12166	69	69	but	but	CCONJ
ecj-12166	69	70	not	not	PART
ecj-12166	69	71	intracranial	intracranial	ADJ
ecj-12166	69	72	pressure.34,35	pressure.34,35	NOUN
ecj-12166	69	73	ketamine	ketamine	NOUN
ecj-12166	69	74	is	be	AUX
ecj-12166	69	75	safe	safe	ADJ
ecj-12166	69	76	in	in	ADP
ecj-12166	69	77	head	head	NOUN
ecj-12166	69	78	trauma	trauma	NOUN
ecj-12166	69	79	,	,	PUNCT
ecj-12166	69	80	and	and	CCONJ
ecj-12166	69	81	the	the	DET
ecj-12166	69	82	myth	myth	NOUN
ecj-12166	69	83	of	of	ADP
ecj-12166	69	84	this	this	DET
ecj-12166	69	85	contraindication	contraindication	NOUN
ecj-12166	69	86	has	have	AUX
ecj-12166	69	87	been	be	AUX
ecj-12166	69	88	overcome	overcome	VERB
ecj-12166	69	89	:	:	PUNCT
ecj-12166	69	90	its	its	PRON
ecj-12166	69	91	action	action	NOUN
ecj-12166	69	92	of	of	ADP
ecj-12166	69	93	increasing	increase	VERB
ecj-12166	69	94	intracranial	intracranial	ADJ
ecj-12166	69	95	pressure	pressure	NOUN
ecj-12166	69	96	is	be	AUX
ecj-12166	69	97	entirely	entirely	ADV
ecj-12166	69	98	negligible	negligible	ADJ
ecj-12166	69	99	,	,	PUNCT
ecj-12166	69	100	and	and	CCONJ
ecj-12166	69	101	its	its	PRON
ecj-12166	69	102	neuroprotective	neuroprotective	ADJ
ecj-12166	69	103	action	action	NOUN
ecj-12166	69	104	due	due	ADP
ecj-12166	69	105	to	to	ADP
ecj-12166	69	106	blockade	blockade	NOUN
ecj-12166	69	107	of	of	ADP
ecj-12166	69	108	nmdar	nmdar	NOUN
ecj-12166	69	109	neurons	neuron	NOUN
ecj-12166	69	110	with	with	ADP
ecj-12166	69	111	glutamate	glutamate	NOUN
ecj-12166	69	112	-	-	PUNCT
ecj-12166	69	113	induced	induce	VERB
ecj-12166	69	114	inhibition	inhibition	NOUN
ecj-12166	69	115	of	of	ADP
ecj-12166	69	116	neural	neural	ADJ
ecj-12166	69	117	edema	edema	NOUN
ecj-12166	69	118	prevails.36–38	prevails.36–38	X
ecj-12166	69	119	in	in	ADP
ecj-12166	69	120	the	the	DET
ecj-12166	69	121	ed	ed	NOUN
ecj-12166	69	122	,	,	PUNCT
ecj-12166	69	123	ketamine	ketamine	PROPN
ecj-12166	69	124	plays	play	VERB
ecj-12166	69	125	an	an	DET
ecj-12166	69	126	important	important	ADJ
ecj-12166	69	127	role	role	NOUN
ecj-12166	69	128	in	in	ADP
ecj-12166	69	129	procedural	procedural	ADJ
ecj-12166	69	130	sedation	sedation	NOUN
ecj-12166	69	131	,	,	PUNCT
ecj-12166	69	132	in	in	ADP
ecj-12166	69	133	the	the	DET
ecj-12166	69	134	management	management	NOUN
ecj-12166	69	135	of	of	ADP
ecj-12166	69	136	acute	acute	ADJ
ecj-12166	69	137	and	and	CCONJ
ecj-12166	69	138	chronic	chronic	ADJ
ecj-12166	69	139	pain	pain	NOUN
ecj-12166	69	140	,	,	PUNCT
ecj-12166	69	141	and	and	CCONJ
ecj-12166	69	142	in	in	ADP
ecj-12166	69	143	acute	acute	ADJ
ecj-12166	69	144	agitation	agitation	NOUN
ecj-12166	69	145	in	in	ADP
ecj-12166	69	146	the	the	DET
ecj-12166	69	147	case	case	NOUN
ecj-12166	69	148	of	of	ADP
ecj-12166	69	149	bdz	bdz	NOUN
ecj-12166	69	150	-	-	PUNCT
ecj-12166	69	151	resistant	resistant	ADJ
ecj-12166	69	152	acute	acute	NOUN
ecj-12166	69	153	aws,39	aws,39	NOUN
ecj-12166	69	154	and	and	CCONJ
ecj-12166	69	155	substance	substance	NOUN
ecj-12166	69	156	-	-	PUNCT
ecj-12166	69	157	use	use	NOUN
ecj-12166	69	158	disorder,10	disorder,10	NOUN
ecj-12166	69	159	but	but	CCONJ
ecj-12166	69	160	also	also	ADV
ecj-12166	69	161	in	in	ADP
ecj-12166	69	162	psychotic	psychotic	ADJ
ecj-12166	69	163	delirium40	delirium40	NOUN
ecj-12166	69	164	or	or	CCONJ
ecj-12166	69	165	hyperactive	hyperactive	ADJ
ecj-12166	69	166	delirium	delirium	NOUN
ecj-12166	69	167	with	with	ADP
ecj-12166	69	168	severe	severe	ADJ
ecj-12166	69	169	agitation,11	agitation,11	NOUN
ecj-12166	69	170	as	as	SCONJ
ecj-12166	69	171	reported	report	VERB
ecj-12166	69	172	in	in	ADP
ecj-12166	69	173	our	our	PRON
ecj-12166	69	174	experience	experience	NOUN
ecj-12166	69	175	.	.	PUNCT
ecj-12166	70	1	aws	aw	NOUN
ecj-12166	70	2	is	be	AUX
ecj-12166	70	3	a	a	DET
ecj-12166	70	4	potentially	potentially	ADV
ecj-12166	70	5	life	life	NOUN
ecj-12166	70	6	-	-	PUNCT
ecj-12166	70	7	threatening	threaten	VERB
ecj-12166	70	8	condition	condition	NOUN
ecj-12166	70	9	that	that	PRON
ecj-12166	70	10	requires	require	VERB
ecj-12166	70	11	immediate	immediate	ADJ
ecj-12166	70	12	treatment	treatment	NOUN
ecj-12166	70	13	to	to	PART
ecj-12166	70	14	avoid	avoid	VERB
ecj-12166	70	15	progression	progression	NOUN
ecj-12166	70	16	to	to	ADP
ecj-12166	70	17	delirium	delirium	NOUN
ecj-12166	70	18	tremens.41	tremens.41	ADP
ecj-12166	70	19	the	the	DET
ecj-12166	70	20	withdrawal	withdrawal	NOUN
ecj-12166	70	21	symptoms	symptom	NOUN
ecj-12166	70	22	vary	vary	VERB
ecj-12166	70	23	from	from	ADP
ecj-12166	70	24	hallucinations	hallucination	NOUN
ecj-12166	70	25	and	and	CCONJ
ecj-12166	70	26	seizures	seizure	NOUN
ecj-12166	70	27	to	to	ADP
ecj-12166	70	28	delirium	delirium	NOUN
ecj-12166	70	29	tremens	tremen	NOUN
ecj-12166	70	30	.	.	PUNCT
ecj-12166	71	1	although	although	SCONJ
ecj-12166	71	2	bzds	bzds	ADJ
ecj-12166	71	3	have	have	AUX
ecj-12166	71	4	been	be	AUX
ecj-12166	71	5	considered	consider	VERB
ecj-12166	71	6	firstline	firstline	ADJ
ecj-12166	71	7	agents	agent	NOUN
ecj-12166	71	8	for	for	ADP
ecj-12166	71	9	the	the	DET
ecj-12166	71	10	prevention	prevention	NOUN
ecj-12166	71	11	and/or	and/or	CCONJ
ecj-12166	71	12	the	the	DET
ecj-12166	71	13	treatment	treatment	NOUN
ecj-12166	71	14	of	of	ADP
ecj-12166	71	15	aws	aw	NOUN
ecj-12166	71	16	,	,	PUNCT
ecj-12166	71	17	lowering	lower	VERB
ecj-12166	71	18	mortality	mortality	NOUN
ecj-12166	71	19	and	and	CCONJ
ecj-12166	71	20	symptoms	symptom	NOUN
ecj-12166	71	21	,	,	PUNCT
ecj-12166	71	22	they	they	PRON
ecj-12166	71	23	are	be	AUX
ecj-12166	71	24	associated	associate	VERB
ecj-12166	71	25	with	with	ADP
ecj-12166	71	26	respiratory	respiratory	ADJ
ecj-12166	71	27	depression	depression	NOUN
ecj-12166	71	28	,	,	PUNCT
ecj-12166	71	29	and	and	CCONJ
ecj-12166	71	30	some	some	DET
ecj-12166	71	31	patients	patient	NOUN
ecj-12166	71	32	may	may	AUX
ecj-12166	71	33	experience	experience	VERB
ecj-12166	71	34	bzd	bzd	NOUN
ecj-12166	71	35	-	-	PUNCT
ecj-12166	71	36	resistant	resistant	ADJ
ecj-12166	71	37	alcohol	alcohol	NOUN
ecj-12166	71	38	withdrawal.39,42	withdrawal.39,42	VERB
ecj-12166	71	39	the	the	DET
ecj-12166	71	40	first	first	ADJ
ecj-12166	71	41	case	case	NOUN
ecj-12166	71	42	report	report	NOUN
ecj-12166	71	43	of	of	ADP
ecj-12166	71	44	this	this	DET
ecj-12166	71	45	manuscript	manuscript	NOUN
ecj-12166	71	46	depicts	depict	VERB
ecj-12166	71	47	a	a	DET
ecj-12166	71	48	male	male	ADJ
ecj-12166	71	49	patient	patient	NOUN
ecj-12166	71	50	who	who	PRON
ecj-12166	71	51	is	be	AUX
ecj-12166	71	52	still	still	ADV
ecj-12166	71	53	agitated	agitated	ADJ
ecj-12166	71	54	and	and	CCONJ
ecj-12166	71	55	hyperdynamic	hyperdynamic	ADJ
ecj-12166	71	56	after	after	ADP
ecj-12166	71	57	receiving	receive	VERB
ecj-12166	71	58	large	large	ADJ
ecj-12166	71	59	doses	dose	NOUN
ecj-12166	71	60	of	of	ADP
ecj-12166	71	61	bzd	bzd	NOUN
ecj-12166	71	62	.	.	PUNCT
ecj-12166	72	1	as	as	SCONJ
ecj-12166	72	2	demonstrated	demonstrate	VERB
ecj-12166	72	3	by	by	ADP
ecj-12166	72	4	the	the	DET
ecj-12166	72	5	case	case	NOUN
ecj-12166	72	6	,	,	PUNCT
ecj-12166	72	7	ketamine	ketamine	PROPN
ecj-12166	72	8	at	at	ADP
ecj-12166	72	9	a	a	DET
ecj-12166	72	10	sub	sub	ADJ
ecj-12166	72	11	-	-	ADJ
ecj-12166	72	12	dissociative	dissociative	ADJ
ecj-12166	72	13	dose	dose	NOUN
ecj-12166	72	14	becomes	become	VERB
ecj-12166	72	15	an	an	DET
ecj-12166	72	16	attractive	attractive	ADJ
ecj-12166	72	17	agent	agent	NOUN
ecj-12166	72	18	for	for	ADP
ecj-12166	72	19	the	the	DET
ecj-12166	72	20	treatment	treatment	NOUN
ecj-12166	72	21	of	of	ADP
ecj-12166	72	22	bzd	bzd	NOUN
ecj-12166	72	23	-	-	PUNCT
ecj-12166	72	24	resistant	resistant	ADJ
ecj-12166	72	25	aws	aw	NOUN
ecj-12166	72	26	,	,	PUNCT
ecj-12166	72	27	with	with	ADP
ecj-12166	72	28	earlier	early	ADJ
ecj-12166	72	29	resolution	resolution	NOUN
ecj-12166	72	30	of	of	ADP
ecj-12166	72	31	delirium	delirium	NOUN
ecj-12166	72	32	tremens	tremen	NOUN
ecj-12166	72	33	,	,	PUNCT
ecj-12166	72	34	not	not	PART
ecj-12166	72	35	inducing	induce	VERB
ecj-12166	72	36	respiratory	respiratory	ADJ
ecj-12166	72	37	depression	depression	NOUN
ecj-12166	72	38	and	and	CCONJ
ecj-12166	72	39	preserving	preserve	VERB
ecj-12166	72	40	the	the	DET
ecj-12166	72	41	patient	patient	NOUN
ecj-12166	72	42	’s	’s	PART
ecj-12166	72	43	protective	protective	ADJ
ecj-12166	72	44	reflexes	reflex	NOUN
ecj-12166	72	45	and	and	CCONJ
ecj-12166	72	46	vital	vital	ADJ
ecj-12166	72	47	functions.43	functions.43	ADJ
ecj-12166	72	48	ketamine	ketamine	NOUN
ecj-12166	72	49	,	,	PUNCT
ecj-12166	72	50	as	as	ADP
ecj-12166	72	51	an	an	DET
ecj-12166	72	52	nmda	nmda	ADJ
ecj-12166	72	53	antagonist	antagonist	NOUN
ecj-12166	72	54	,	,	PUNCT
ecj-12166	72	55	stimulates	stimulate	VERB
ecj-12166	72	56	the	the	DET
ecj-12166	72	57	gaba	gaba	NOUN
ecj-12166	72	58	receptors	receptor	NOUN
ecj-12166	72	59	and	and	CCONJ
ecj-12166	72	60	inhibits	inhibit	VERB
ecj-12166	72	61	the	the	DET
ecj-12166	72	62	nmda	nmda	ADJ
ecj-12166	72	63	-	-	PUNCT
ecj-12166	72	64	glutamate	glutamate	NOUN
ecj-12166	72	65	receptors	receptor	NOUN
ecj-12166	72	66	,	,	PUNCT
ecj-12166	72	67	miming	mime	VERB
ecj-12166	72	68	the	the	DET
ecj-12166	72	69	action	action	NOUN
ecj-12166	72	70	of	of	ADP
ecj-12166	72	71	alcohol	alcohol	NOUN
ecj-12166	72	72	and	and	CCONJ
ecj-12166	72	73	reducing	reduce	VERB
ecj-12166	72	74	alcohol	alcohol	NOUN
ecj-12166	72	75	cravings.44	cravings.44	NOUN
ecj-12166	72	76	according	accord	VERB
ecj-12166	72	77	to	to	ADP
ecj-12166	72	78	garel	garel	NOUN
ecj-12166	72	79	et	et	PROPN
ecj-12166	72	80	al	al	PROPN
ecj-12166	72	81	.	.	PROPN
ecj-12166	72	82	,45	,45	PROPN
ecj-12166	72	83	ketamine	ketamine	PROPN
ecj-12166	72	84	can	can	AUX
ecj-12166	72	85	help	help	VERB
ecj-12166	72	86	to	to	PART
ecj-12166	72	87	manage	manage	VERB
ecj-12166	72	88	both	both	DET
ecj-12166	72	89	aws	aws	NOUN
ecj-12166	72	90	and	and	CCONJ
ecj-12166	72	91	substance	substance	NOUN
ecj-12166	72	92	use	use	NOUN
ecj-12166	72	93	disorder	disorder	NOUN
ecj-12166	72	94	by	by	ADP
ecj-12166	72	95	reducing	reduce	VERB
ecj-12166	72	96	withdrawal	withdrawal	NOUN
ecj-12166	72	97	symptoms	symptom	NOUN
ecj-12166	72	98	,	,	PUNCT
ecj-12166	72	99	promoting	promote	VERB
ecj-12166	72	100	abstinence	abstinence	NOUN
ecj-12166	72	101	,	,	PUNCT
ecj-12166	72	102	and	and	CCONJ
ecj-12166	72	103	decreasing	decrease	VERB
ecj-12166	72	104	cravings	craving	NOUN
ecj-12166	72	105	in	in	ADP
ecj-12166	72	106	alcohol	alcohol	NOUN
ecj-12166	72	107	and	and	CCONJ
ecj-12166	72	108	cocaine	cocaine	NOUN
ecj-12166	72	109	use	use	NOUN
ecj-12166	72	110	disorders.46	disorders.46	PROPN
ecj-12166	72	111	jones	jones	PROPN
ecj-12166	72	112	et	et	PROPN
ecj-12166	72	113	al.10	al.10	PROPN
ecj-12166	72	114	also	also	ADV
ecj-12166	72	115	demonstrated	demonstrate	VERB
ecj-12166	72	116	that	that	SCONJ
ecj-12166	72	117	ketamine	ketamine	PROPN
ecj-12166	72	118	may	may	AUX
ecj-12166	72	119	play	play	VERB
ecj-12166	72	120	a	a	DET
ecj-12166	72	121	therapeutic	therapeutic	ADJ
ecj-12166	72	122	role	role	NOUN
ecj-12166	72	123	in	in	ADP
ecj-12166	72	124	enhancing	enhance	VERB
ecj-12166	72	125	long	long	ADJ
ecj-12166	72	126	-	-	PUNCT
ecj-12166	72	127	term	term	NOUN
ecj-12166	72	128	complete	complete	ADJ
ecj-12166	72	129	abstinence	abstinence	NOUN
ecj-12166	72	130	from	from	ADP
ecj-12166	72	131	alcohol	alcohol	NOUN
ecj-12166	72	132	and	and	CCONJ
ecj-12166	72	133	cocaine	cocaine	NOUN
ecj-12166	72	134	.	.	PUNCT
ecj-12166	73	1	in	in	ADP
ecj-12166	73	2	the	the	DET
ecj-12166	73	3	position	position	NOUN
ecj-12166	73	4	paper	paper	NOUN
ecj-12166	73	5	of	of	ADP
ecj-12166	73	6	the	the	DET
ecj-12166	73	7	american	american	PROPN
ecj-12166	73	8	academy	academy	PROPN
ecj-12166	73	9	of	of	ADP
ecj-12166	73	10	emergency	emergency	NOUN
ecj-12166	73	11	medicine	medicine	NOUN
ecj-12166	73	12	,	,	PUNCT
ecj-12166	73	13	ketamine	ketamine	PROPN
ecj-12166	73	14	is	be	AUX
ecj-12166	73	15	mentioned	mention	VERB
ecj-12166	73	16	in	in	ADP
ecj-12166	73	17	the	the	DET
ecj-12166	73	18	list	list	NOUN
ecj-12166	73	19	of	of	ADP
ecj-12166	73	20	medications	medication	NOUN
ecj-12166	73	21	for	for	ADP
ecj-12166	73	22	treating	treat	VERB
ecj-12166	73	23	agitation	agitation	NOUN
ecj-12166	73	24	in	in	ADP
ecj-12166	73	25	patients	patient	NOUN
ecj-12166	73	26	with	with	ADP
ecj-12166	73	27	alcohol	alcohol	NOUN
ecj-12166	73	28	intoxication	intoxication	NOUN
ecj-12166	73	29	,	,	PUNCT
ecj-12166	73	30	alcohol	alcohol	NOUN
ecj-12166	73	31	withdrawal	withdrawal	NOUN
ecj-12166	73	32	,	,	PUNCT
ecj-12166	73	33	and	and	CCONJ
ecj-12166	73	34	alcohol	alcohol	NOUN
ecj-12166	73	35	use	use	NOUN
ecj-12166	73	36	disorder	disorder	NOUN
ecj-12166	73	37	in	in	ADP
ecj-12166	73	38	the	the	DET
ecj-12166	73	39	eds.42	eds.42	NOUN
ecj-12166	73	40	according	accord	VERB
ecj-12166	73	41	to	to	ADP
ecj-12166	73	42	the	the	DET
ecj-12166	73	43	authors	author	NOUN
ecj-12166	73	44	,	,	PUNCT
ecj-12166	73	45	for	for	ADP
ecj-12166	73	46	agitated	agitated	ADJ
ecj-12166	73	47	patients	patient	NOUN
ecj-12166	73	48	who	who	PRON
ecj-12166	73	49	are	be	AUX
ecj-12166	73	50	uncontrollably	uncontrollably	ADV
ecj-12166	73	51	violent	violent	ADJ
ecj-12166	73	52	with	with	ADP
ecj-12166	73	53	concern	concern	NOUN
ecj-12166	73	54	for	for	ADP
ecj-12166	73	55	immediate	immediate	ADJ
ecj-12166	73	56	harm	harm	NOUN
ecj-12166	73	57	to	to	ADP
ecj-12166	73	58	self	self	NOUN
ecj-12166	73	59	or	or	CCONJ
ecj-12166	73	60	others	other	NOUN
ecj-12166	73	61	,	,	PUNCT
ecj-12166	73	62	or	or	CCONJ
ecj-12166	73	63	if	if	SCONJ
ecj-12166	73	64	there	there	PRON
ecj-12166	73	65	is	be	VERB
ecj-12166	73	66	a	a	DET
ecj-12166	73	67	concern	concern	NOUN
ecj-12166	73	68	for	for	ADP
ecj-12166	73	69	an	an	DET
ecj-12166	73	70	immediately	immediately	ADV
ecj-12166	73	71	life	life	NOUN
ecj-12166	73	72	-	-	PUNCT
ecj-12166	73	73	threatening	threaten	VERB
ecj-12166	73	74	medical	medical	ADJ
ecj-12166	73	75	condition	condition	NOUN
ecj-12166	73	76	whose	whose	DET
ecj-12166	73	77	diagnosis	diagnosis	NOUN
ecj-12166	73	78	and	and	CCONJ
ecj-12166	73	79	management	management	NOUN
ecj-12166	73	80	is	be	AUX
ecj-12166	73	81	hindered	hinder	VERB
ecj-12166	73	82	by	by	ADP
ecj-12166	73	83	agitation	agitation	NOUN
ecj-12166	73	84	,	,	PUNCT
ecj-12166	73	85	dissociative	dissociative	ADJ
ecj-12166	73	86	-	-	PUNCT
ecj-12166	73	87	dose	dose	NOUN
ecj-12166	73	88	ketamine	ketamine	NOUN
ecj-12166	73	89	(	(	PUNCT
ecj-12166	73	90	4	4	NUM
ecj-12166	73	91	-	-	SYM
ecj-12166	73	92	5	5	NUM
ecj-12166	73	93	mg	mg	NUM
ecj-12166	73	94	/	/	SYM
ecj-12166	73	95	kg	kg	PROPN
ecj-12166	74	1	i	i	PRON
ecj-12166	74	2	m	m	VERB
ecj-12166	74	3	or	or	CCONJ
ecj-12166	74	4	1	1	NUM
ecj-12166	74	5	-	-	SYM
ecj-12166	74	6	2	2	NUM
ecj-12166	74	7	mg	mg	PROPN
ecj-12166	74	8	/	/	SYM
ecj-12166	74	9	kg	kg	NOUN
ecj-12166	74	10	iv	iv	NOUN
ecj-12166	74	11	)	)	PUNCT
ecj-12166	74	12	mini	mini	ADJ
ecj-12166	74	13	review	review	NOUN
ecj-12166	75	1	[	[	X
ecj-12166	75	2	page	page	NOUN
ecj-12166	75	3	32	32	NUM
ecj-12166	75	4	]	]	PUNCT
ecj-12166	76	1	[	[	X
ecj-12166	76	2	emergency	emergency	NOUN
ecj-12166	76	3	care	care	NOUN
ecj-12166	76	4	journal	journal	PROPN
ecj-12166	76	5	2024	2024	NUM
ecj-12166	76	6	;	;	PUNCT
ecj-12166	76	7	20:12166	20:12166	NUM
ecj-12166	76	8	]	]	X
ecj-12166	76	9	non	non	ADJ
ecj-12166	76	10	-co	-co	PROPN
ecj-12166	76	11	mmerc	mmerc	PROPN
ecj-12166	76	12	ial	ial	PROPN
ecj-12166	76	13	us	us	PROPN
ecj-12166	76	14	e	e	NOUN
ecj-12166	76	15	o	o	NOUN
ecj-12166	76	16	nly	nly	ADV
ecj-12166	76	17	should	should	AUX
ecj-12166	76	18	be	be	AUX
ecj-12166	76	19	considered	consider	VERB
ecj-12166	76	20	.	.	PUNCT
ecj-12166	77	1	these	these	DET
ecj-12166	77	2	patients	patient	NOUN
ecj-12166	77	3	require	require	VERB
ecj-12166	77	4	procedural	procedural	ADJ
ecj-12166	77	5	sedationlevel	sedationlevel	NOUN
ecj-12166	77	6	care	care	NOUN
ecj-12166	77	7	with	with	ADP
ecj-12166	77	8	an	an	DET
ecj-12166	77	9	airway	airway	NOUN
ecj-12166	77	10	-	-	PUNCT
ecj-12166	77	11	capable	capable	ADJ
ecj-12166	77	12	clinician	clinician	NOUN
ecj-12166	77	13	available	available	ADJ
ecj-12166	77	14	and	and	CCONJ
ecj-12166	77	15	vigilant	vigilant	ADJ
ecj-12166	77	16	attention	attention	NOUN
ecj-12166	77	17	paid	pay	VERB
ecj-12166	77	18	to	to	ADP
ecj-12166	77	19	ventilation	ventilation	NOUN
ecj-12166	77	20	until	until	ADP
ecj-12166	77	21	dissociation	dissociation	NOUN
ecj-12166	77	22	resolves	resolve	NOUN
ecj-12166	77	23	or	or	CCONJ
ecj-12166	77	24	the	the	DET
ecj-12166	77	25	patient	patient	NOUN
ecj-12166	77	26	is	be	AUX
ecj-12166	77	27	intubated.42	intubated.42	NOUN
ecj-12166	77	28	in	in	ADP
ecj-12166	77	29	the	the	DET
ecj-12166	77	30	case	case	NOUN
ecj-12166	77	31	of	of	ADP
ecj-12166	77	32	bdz	bdz	NOUN
ecj-12166	77	33	-	-	PUNCT
ecj-12166	77	34	resistant	resistant	ADJ
ecj-12166	77	35	psychomotor	psychomotor	NOUN
ecj-12166	77	36	agitation	agitation	NOUN
ecj-12166	77	37	,	,	PUNCT
ecj-12166	77	38	psychiatric	psychiatric	ADJ
ecj-12166	77	39	disorders	disorder	NOUN
ecj-12166	77	40	,	,	PUNCT
ecj-12166	77	41	or	or	CCONJ
ecj-12166	77	42	hyperactive	hyperactive	ADJ
ecj-12166	77	43	delirium	delirium	NOUN
ecj-12166	77	44	with	with	ADP
ecj-12166	77	45	severe	severe	ADJ
ecj-12166	77	46	agitation	agitation	NOUN
ecj-12166	77	47	,	,	PUNCT
ecj-12166	77	48	as	as	SCONJ
ecj-12166	77	49	in	in	ADP
ecj-12166	77	50	cases	case	NOUN
ecj-12166	77	51	2	2	NUM
ecj-12166	77	52	and	and	CCONJ
ecj-12166	77	53	3	3	NUM
ecj-12166	77	54	,	,	PUNCT
ecj-12166	77	55	ketamine	ketamine	PROPN
ecj-12166	77	56	becomes	become	VERB
ecj-12166	77	57	an	an	DET
ecj-12166	77	58	important	important	ADJ
ecj-12166	77	59	alternative	alternative	NOUN
ecj-12166	77	60	for	for	ADP
ecj-12166	77	61	the	the	DET
ecj-12166	77	62	acute	acute	ADJ
ecj-12166	77	63	management	management	NOUN
ecj-12166	77	64	of	of	ADP
ecj-12166	77	65	agitation	agitation	NOUN
ecj-12166	77	66	at	at	ADP
ecj-12166	77	67	a	a	DET
ecj-12166	77	68	dissociative	dissociative	ADJ
ecj-12166	77	69	dose	dose	NOUN
ecj-12166	77	70	of	of	ADP
ecj-12166	77	71	2	2	NUM
ecj-12166	77	72	mg	mg	PROPN
ecj-12166	77	73	/	/	SYM
ecj-12166	77	74	kg	kg	NOUN
ecj-12166	77	75	iv	iv	ADP
ecj-12166	77	76	or	or	CCONJ
ecj-12166	77	77	5	5	NUM
ecj-12166	77	78	mg	mg	PROPN
ecj-12166	77	79	/	/	SYM
ecj-12166	77	80	kg	kg	PROPN
ecj-12166	77	81	im.11,40	im.11,40	VERB
ecj-12166	77	82	the	the	DET
ecj-12166	77	83	optimal	optimal	ADJ
ecj-12166	77	84	management	management	NOUN
ecj-12166	77	85	strategy	strategy	NOUN
ecj-12166	77	86	for	for	ADP
ecj-12166	77	87	these	these	DET
ecj-12166	77	88	patients	patient	NOUN
ecj-12166	77	89	includes	include	VERB
ecj-12166	77	90	immediate	immediate	ADJ
ecj-12166	77	91	i	i	PROPN
ecj-12166	77	92	m	m	PROPN
ecj-12166	77	93	administration	administration	NOUN
ecj-12166	77	94	and	and	CCONJ
ecj-12166	77	95	rapid	rapid	ADJ
ecj-12166	77	96	sedation	sedation	NOUN
ecj-12166	77	97	,	,	PUNCT
ecj-12166	77	98	followed	follow	VERB
ecj-12166	77	99	by	by	ADP
ecj-12166	77	100	airway	airway	NOUN
ecj-12166	77	101	protection	protection	NOUN
ecj-12166	77	102	,	,	PUNCT
ecj-12166	77	103	supportive	supportive	ADJ
ecj-12166	77	104	measures	measure	NOUN
ecj-12166	77	105	,	,	PUNCT
ecj-12166	77	106	and	and	CCONJ
ecj-12166	77	107	cooling	cool	VERB
ecj-12166	77	108	of	of	ADP
ecj-12166	77	109	hyperthermic	hyperthermic	ADJ
ecj-12166	77	110	patients	patient	NOUN
ecj-12166	77	111	.	.	PUNCT
ecj-12166	78	1	ketamine	ketamine	PROPN
ecj-12166	78	2	has	have	VERB
ecj-12166	78	3	a	a	DET
ecj-12166	78	4	rapid	rapid	ADJ
ecj-12166	78	5	onset	onset	NOUN
ecj-12166	78	6	of	of	ADP
ecj-12166	78	7	action	action	NOUN
ecj-12166	78	8	(	(	PUNCT
ecj-12166	78	9	30	30	NUM
ecj-12166	78	10	sec	sec	PROPN
ecj-12166	78	11	iv	iv	NUM
ecj-12166	78	12	,	,	PUNCT
ecj-12166	78	13	2	2	NUM
ecj-12166	78	14	-	-	SYM
ecj-12166	78	15	15	15	NUM
ecj-12166	78	16	min	min	NOUN
ecj-12166	78	17	im),11	im),11	NOUN
ecj-12166	78	18	a	a	DET
ecj-12166	78	19	short	short	ADJ
ecj-12166	78	20	transit	transit	NOUN
ecj-12166	78	21	time	time	NOUN
ecj-12166	78	22	,	,	PUNCT
ecj-12166	78	23	and	and	CCONJ
ecj-12166	78	24	a	a	DET
ecj-12166	78	25	safety	safety	NOUN
ecj-12166	78	26	profile	profile	NOUN
ecj-12166	78	27	for	for	ADP
ecj-12166	78	28	its	its	PRON
ecj-12166	78	29	ability	ability	NOUN
ecj-12166	78	30	to	to	PART
ecj-12166	78	31	maintain	maintain	VERB
ecj-12166	78	32	airway	airway	NOUN
ecj-12166	78	33	reflexes	reflex	NOUN
ecj-12166	78	34	,	,	PUNCT
ecj-12166	78	35	as	as	SCONJ
ecj-12166	78	36	demonstrated	demonstrate	VERB
ecj-12166	78	37	in	in	ADP
ecj-12166	78	38	case	case	NOUN
ecj-12166	78	39	3	3	NUM
ecj-12166	78	40	,	,	PUNCT
ecj-12166	78	41	in	in	ADP
ecj-12166	78	42	which	which	PRON
ecj-12166	78	43	our	our	PRON
ecj-12166	78	44	patient	patient	NOUN
ecj-12166	78	45	maintained	maintain	VERB
ecj-12166	78	46	spontaneous	spontaneous	ADJ
ecj-12166	78	47	respiration	respiration	NOUN
ecj-12166	78	48	after	after	ADP
ecj-12166	78	49	receiving	receive	VERB
ecj-12166	78	50	a	a	DET
ecj-12166	78	51	high	high	ADJ
ecj-12166	78	52	dose	dose	NOUN
ecj-12166	78	53	of	of	ADP
ecj-12166	78	54	ketamine	ketamine	PROPN
ecj-12166	78	55	.	.	PUNCT
ecj-12166	79	1	for	for	ADP
ecj-12166	79	2	these	these	DET
ecj-12166	79	3	reasons	reason	NOUN
ecj-12166	79	4	,	,	PUNCT
ecj-12166	79	5	ketamine	ketamine	PROPN
ecj-12166	79	6	can	can	AUX
ecj-12166	79	7	be	be	AUX
ecj-12166	79	8	considered	consider	VERB
ecj-12166	79	9	the	the	DET
ecj-12166	79	10	ideal	ideal	ADJ
ecj-12166	79	11	first	first	ADJ
ecj-12166	79	12	-	-	PUNCT
ecj-12166	79	13	line	line	NOUN
ecj-12166	79	14	medication	medication	NOUN
ecj-12166	79	15	for	for	ADP
ecj-12166	79	16	hyperactive	hyperactive	ADJ
ecj-12166	79	17	delirium	delirium	NOUN
ecj-12166	79	18	in	in	ADP
ecj-12166	79	19	the	the	DET
ecj-12166	79	20	pre	pre	NOUN
ecj-12166	79	21	-	-	NOUN
ecj-12166	79	22	hospital	hospital	ADJ
ecj-12166	79	23	or	or	CCONJ
ecj-12166	79	24	ed	ed	NOUN
ecj-12166	79	25	setting	setting	NOUN
ecj-12166	79	26	.	.	PUNCT
ecj-12166	80	1	even	even	ADV
ecj-12166	80	2	if	if	SCONJ
ecj-12166	80	3	ketamine	ketamine	PROPN
ecj-12166	80	4	has	have	VERB
ecj-12166	80	5	a	a	DET
ecj-12166	80	6	well	well	ADV
ecj-12166	80	7	-	-	PUNCT
ecj-12166	80	8	known	know	VERB
ecj-12166	80	9	effect	effect	NOUN
ecj-12166	80	10	on	on	ADP
ecj-12166	80	11	the	the	DET
ecj-12166	80	12	nmda	nmda	ADJ
ecj-12166	80	13	receptors	receptor	NOUN
ecj-12166	80	14	,	,	PUNCT
ecj-12166	80	15	it	it	PRON
ecj-12166	80	16	is	be	AUX
ecj-12166	80	17	involved	involve	VERB
ecj-12166	80	18	in	in	ADP
ecj-12166	80	19	multiple	multiple	ADJ
ecj-12166	80	20	other	other	ADJ
ecj-12166	80	21	pathways	pathway	NOUN
ecj-12166	80	22	like	like	ADP
ecj-12166	80	23	opioid	opioid	ADJ
ecj-12166	80	24	receptors	receptor	NOUN
ecj-12166	80	25	,	,	PUNCT
ecj-12166	80	26	nicotinic	nicotinic	ADJ
ecj-12166	80	27	and	and	CCONJ
ecj-12166	80	28	muscarinic	muscarinic	ADJ
ecj-12166	80	29	receptors	receptor	NOUN
ecj-12166	80	30	,	,	PUNCT
ecj-12166	80	31	and	and	CCONJ
ecj-12166	80	32	dopamine	dopamine	NOUN
ecj-12166	80	33	receptors	receptor	NOUN
ecj-12166	80	34	,	,	PUNCT
ecj-12166	80	35	with	with	SCONJ
ecj-12166	80	36	an	an	DET
ecj-12166	80	37	analgesic	analgesic	ADJ
ecj-12166	80	38	activity.47,48	activity.47,48	ADJ
ecj-12166	80	39	opioids	opioid	NOUN
ecj-12166	80	40	are	be	AUX
ecj-12166	80	41	considered	consider	VERB
ecj-12166	80	42	the	the	DET
ecj-12166	80	43	cornerstone	cornerstone	NOUN
ecj-12166	80	44	for	for	ADP
ecj-12166	80	45	the	the	DET
ecj-12166	80	46	treatment	treatment	NOUN
ecj-12166	80	47	of	of	ADP
ecj-12166	80	48	severe	severe	ADJ
ecj-12166	80	49	pain	pain	NOUN
ecj-12166	80	50	,	,	PUNCT
ecj-12166	80	51	but	but	CCONJ
ecj-12166	80	52	the	the	DET
ecj-12166	80	53	analgesic	analgesic	ADJ
ecj-12166	80	54	dose	dose	NOUN
ecj-12166	80	55	of	of	ADP
ecj-12166	80	56	ketamine	ketamine	PROPN
ecj-12166	80	57	(	(	PUNCT
ecj-12166	80	58	0.15	0.15	NUM
ecj-12166	80	59	-	-	SYM
ecj-12166	80	60	0.3	0.3	NUM
ecj-12166	80	61	mg	mg	PROPN
ecj-12166	80	62	/	/	SYM
ecj-12166	80	63	kg	kg	PROPN
ecj-12166	80	64	bolus	bolus	NOUN
ecj-12166	80	65	,	,	PUNCT
ecj-12166	80	66	followed	follow	VERB
ecj-12166	80	67	or	or	CCONJ
ecj-12166	80	68	not	not	PART
ecj-12166	80	69	by	by	ADP
ecj-12166	80	70	0.15	0.15	NUM
ecj-12166	80	71	-	-	SYM
ecj-12166	80	72	0.3	0.3	NUM
ecj-12166	80	73	mg	mg	PROPN
ecj-12166	80	74	/	/	SYM
ecj-12166	80	75	kg	kg	PROPN
ecj-12166	80	76	/	/	SYM
ecj-12166	80	77	h	h	NOUN
ecj-12166	80	78	continuous	continuous	ADJ
ecj-12166	80	79	infusion	infusion	NOUN
ecj-12166	80	80	)	)	PUNCT
ecj-12166	80	81	is	be	AUX
ecj-12166	80	82	an	an	DET
ecj-12166	80	83	attractive	attractive	ADJ
ecj-12166	80	84	option.17	option.17	NOUN
ecj-12166	80	85	ketamine	ketamine	PROPN
ecj-12166	80	86	is	be	AUX
ecj-12166	80	87	a	a	DET
ecj-12166	80	88	safe	safe	ADJ
ecj-12166	80	89	and	and	CCONJ
ecj-12166	80	90	effective	effective	ADJ
ecj-12166	80	91	non	non	ADJ
ecj-12166	80	92	-	-	ADJ
ecj-12166	80	93	opioid	opioid	ADJ
ecj-12166	80	94	alternative	alternative	NOUN
ecj-12166	80	95	for	for	ADP
ecj-12166	80	96	a	a	DET
ecj-12166	80	97	variety	variety	NOUN
ecj-12166	80	98	of	of	ADP
ecj-12166	80	99	painful	painful	ADJ
ecj-12166	80	100	conditions	condition	NOUN
ecj-12166	80	101	,	,	PUNCT
ecj-12166	80	102	like	like	ADP
ecj-12166	80	103	acute	acute	NOUN
ecj-12166	80	104	,	,	PUNCT
ecj-12166	80	105	chronic	chronic	ADJ
ecj-12166	80	106	,	,	PUNCT
ecj-12166	80	107	oncologic	oncologic	NOUN
ecj-12166	80	108	,	,	PUNCT
ecj-12166	80	109	and	and	CCONJ
ecj-12166	80	110	refractory	refractory	NOUN
ecj-12166	80	111	pain.49	pain.49	NOUN
ecj-12166	80	112	the	the	DET
ecj-12166	80	113	use	use	NOUN
ecj-12166	80	114	of	of	ADP
ecj-12166	80	115	ketamine	ketamine	PROPN
ecj-12166	80	116	for	for	ADP
ecj-12166	80	117	the	the	DET
ecj-12166	80	118	treatment	treatment	NOUN
ecj-12166	80	119	of	of	ADP
ecj-12166	80	120	acute	acute	ADJ
ecj-12166	80	121	pain	pain	NOUN
ecj-12166	80	122	can	can	AUX
ecj-12166	80	123	have	have	VERB
ecj-12166	80	124	opioid	opioid	NOUN
ecj-12166	80	125	-	-	PUNCT
ecj-12166	80	126	sparing	spare	VERB
ecj-12166	80	127	effects	effect	NOUN
ecj-12166	80	128	without	without	ADP
ecj-12166	80	129	increasing	increase	VERB
ecj-12166	80	130	sedation,4,50	sedation,4,50	PROPN
ecj-12166	80	131	especially	especially	ADV
ecj-12166	80	132	in	in	ADP
ecj-12166	80	133	patients	patient	NOUN
ecj-12166	80	134	at	at	ADP
ecj-12166	80	135	risk	risk	NOUN
ecj-12166	80	136	of	of	ADP
ecj-12166	80	137	opiate	opiate	ADJ
ecj-12166	80	138	-	-	PUNCT
ecj-12166	80	139	related	relate	VERB
ecj-12166	80	140	respiratory	respiratory	ADJ
ecj-12166	80	141	failure	failure	NOUN
ecj-12166	80	142	(	(	PUNCT
ecj-12166	80	143	such	such	ADJ
ecj-12166	80	144	as	as	ADP
ecj-12166	80	145	those	those	PRON
ecj-12166	80	146	with	with	ADP
ecj-12166	80	147	obstructive	obstructive	ADJ
ecj-12166	80	148	sleep	sleep	NOUN
ecj-12166	80	149	apnea	apnea	NOUN
ecj-12166	80	150	)	)	PUNCT
ecj-12166	80	151	since	since	SCONJ
ecj-12166	80	152	it	it	PRON
ecj-12166	80	153	can	can	AUX
ecj-12166	80	154	provide	provide	VERB
ecj-12166	80	155	adequate	adequate	ADJ
ecj-12166	80	156	analgesia	analgesia	NOUN
ecj-12166	80	157	without	without	ADP
ecj-12166	80	158	compromising	compromise	VERB
ecj-12166	80	159	the	the	DET
ecj-12166	80	160	cardiorespiratory	cardiorespiratory	NOUN
ecj-12166	80	161	drive.51	drive.51	NOUN
ecj-12166	80	162	in	in	ADP
ecj-12166	80	163	case	case	NOUN
ecj-12166	80	164	4	4	NUM
ecj-12166	80	165	,	,	PUNCT
ecj-12166	80	166	ketamine	ketamine	PROPN
ecj-12166	80	167	was	be	AUX
ecj-12166	80	168	administered	administer	VERB
ecj-12166	80	169	intravenously	intravenously	ADV
ecj-12166	80	170	at	at	ADP
ecj-12166	80	171	an	an	DET
ecj-12166	80	172	analgesic	analgesic	ADJ
ecj-12166	80	173	dose	dose	NOUN
ecj-12166	80	174	of	of	ADP
ecj-12166	80	175	0.2	0.2	NUM
ecj-12166	80	176	mg	mg	PROPN
ecj-12166	80	177	/	/	SYM
ecj-12166	80	178	kg	kg	PROPN
ecj-12166	80	179	,	,	PUNCT
ecj-12166	80	180	providing	provide	VERB
ecj-12166	80	181	rapid	rapid	ADJ
ecj-12166	80	182	pain	pain	NOUN
ecj-12166	80	183	relief	relief	NOUN
ecj-12166	80	184	,	,	PUNCT
ecj-12166	80	185	after	after	ADP
ecj-12166	80	186	a	a	DET
ecj-12166	80	187	massive	massive	ADJ
ecj-12166	80	188	dose	dose	NOUN
ecj-12166	80	189	of	of	ADP
ecj-12166	80	190	morphine	morphine	NOUN
ecj-12166	80	191	(	(	PUNCT
ecj-12166	80	192	3	3	NUM
ecj-12166	80	193	consecutive	consecutive	ADJ
ecj-12166	80	194	boluses	bolus	NOUN
ecj-12166	80	195	of	of	ADP
ecj-12166	80	196	0.1	0.1	NUM
ecj-12166	80	197	mg	mg	PROPN
ecj-12166	80	198	/	/	SYM
ecj-12166	80	199	kg	kg	PROPN
ecj-12166	80	200	iv	iv	NUM
ecj-12166	80	201	)	)	PUNCT
ecj-12166	80	202	.	.	PUNCT
ecj-12166	81	1	in	in	ADP
ecj-12166	81	2	chronic	chronic	ADJ
ecj-12166	81	3	pain	pain	NOUN
ecj-12166	81	4	,	,	PUNCT
ecj-12166	81	5	the	the	DET
ecj-12166	81	6	nmdar	nmdar	NOUN
ecj-12166	81	7	is	be	AUX
ecj-12166	81	8	upregulated	upregulate	VERB
ecj-12166	81	9	in	in	ADP
ecj-12166	81	10	the	the	DET
ecj-12166	81	11	dorsal	dorsal	NOUN
ecj-12166	81	12	horn	horn	NOUN
ecj-12166	81	13	of	of	ADP
ecj-12166	81	14	the	the	DET
ecj-12166	81	15	spinal	spinal	NOUN
ecj-12166	81	16	cord	cord	NOUN
ecj-12166	81	17	,	,	PUNCT
ecj-12166	81	18	enhancing	enhance	VERB
ecj-12166	81	19	signal	signal	NOUN
ecj-12166	81	20	transmission	transmission	NOUN
ecj-12166	81	21	in	in	ADP
ecj-12166	81	22	the	the	DET
ecj-12166	81	23	pain	pain	NOUN
ecj-12166	81	24	circuitry	circuitry	NOUN
ecj-12166	81	25	and	and	CCONJ
ecj-12166	81	26	leading	lead	VERB
ecj-12166	81	27	to	to	ADP
ecj-12166	81	28	chronic	chronic	ADJ
ecj-12166	81	29	pain	pain	NOUN
ecj-12166	81	30	.	.	PUNCT
ecj-12166	82	1	ketamine	ketamine	PROPN
ecj-12166	82	2	may	may	AUX
ecj-12166	82	3	be	be	AUX
ecj-12166	82	4	able	able	ADJ
ecj-12166	82	5	to	to	PART
ecj-12166	82	6	block	block	VERB
ecj-12166	82	7	this	this	DET
ecj-12166	82	8	sensitization	sensitization	NOUN
ecj-12166	82	9	and	and	CCONJ
ecj-12166	82	10	briefly	briefly	ADV
ecj-12166	82	11	relieve	relieve	VERB
ecj-12166	82	12	chronic	chronic	ADJ
ecj-12166	82	13	pain.52	pain.52	NOUN
ecj-12166	82	14	it	it	PRON
ecj-12166	82	15	is	be	AUX
ecj-12166	82	16	also	also	ADV
ecj-12166	82	17	interesting	interesting	ADJ
ecj-12166	82	18	how	how	SCONJ
ecj-12166	82	19	the	the	DET
ecj-12166	82	20	combination	combination	NOUN
ecj-12166	82	21	of	of	ADP
ecj-12166	82	22	ketamine	ketamine	PROPN
ecj-12166	82	23	with	with	ADP
ecj-12166	82	24	midazolam	midazolam	PROPN
ecj-12166	82	25	or	or	CCONJ
ecj-12166	82	26	propofol	propofol	NOUN
ecj-12166	82	27	(	(	PUNCT
ecj-12166	82	28	“	"	PUNCT
ecj-12166	82	29	ketofol	ketofol	ADJ
ecj-12166	82	30	”	"	PUNCT
ecj-12166	82	31	)	)	PUNCT
ecj-12166	82	32	or	or	CCONJ
ecj-12166	82	33	dexmedetomidine	dexmedetomidine	ADJ
ecj-12166	82	34	(	(	PUNCT
ecj-12166	82	35	“	"	PUNCT
ecj-12166	82	36	ketadex	ketadex	NOUN
ecj-12166	82	37	”	"	PUNCT
ecj-12166	82	38	)	)	PUNCT
ecj-12166	82	39	can	can	AUX
ecj-12166	82	40	be	be	AUX
ecj-12166	82	41	extremely	extremely	ADV
ecj-12166	82	42	useful	useful	ADJ
ecj-12166	82	43	and	and	CCONJ
ecj-12166	82	44	safe	safe	ADJ
ecj-12166	82	45	for	for	ADP
ecj-12166	82	46	sedation	sedation	NOUN
ecj-12166	82	47	and	and	CCONJ
ecj-12166	82	48	pain	pain	NOUN
ecj-12166	82	49	relief	relief	NOUN
ecj-12166	82	50	in	in	ADP
ecj-12166	82	51	intensive	intensive	ADJ
ecj-12166	82	52	care	care	NOUN
ecj-12166	82	53	patients	patient	NOUN
ecj-12166	82	54	,	,	PUNCT
ecj-12166	82	55	especially	especially	ADV
ecj-12166	82	56	during	during	ADP
ecj-12166	82	57	sepsis	sepsis	NOUN
ecj-12166	82	58	,	,	PUNCT
ecj-12166	82	59	cardiovascular	cardiovascular	ADJ
ecj-12166	82	60	instability,21	instability,21	NOUN
ecj-12166	82	61	and	and	CCONJ
ecj-12166	82	62	non	non	ADJ
ecj-12166	82	63	-	-	ADJ
ecj-12166	82	64	invasive	invasive	ADJ
ecj-12166	82	65	ventilation.13–16	ventilation.13–16	NOUN
ecj-12166	82	66	when	when	SCONJ
ecj-12166	82	67	treating	treat	VERB
ecj-12166	82	68	patients	patient	NOUN
ecj-12166	82	69	who	who	PRON
ecj-12166	82	70	have	have	VERB
ecj-12166	82	71	refractory	refractory	NOUN
ecj-12166	82	72	pain	pain	NOUN
ecj-12166	82	73	,	,	PUNCT
ecj-12166	82	74	particularly	particularly	ADV
ecj-12166	82	75	those	those	PRON
ecj-12166	82	76	who	who	PRON
ecj-12166	82	77	are	be	AUX
ecj-12166	82	78	nearing	near	VERB
ecj-12166	82	79	the	the	DET
ecj-12166	82	80	end	end	NOUN
ecj-12166	82	81	of	of	ADP
ecj-12166	82	82	their	their	PRON
ecj-12166	82	83	lives	life	NOUN
ecj-12166	82	84	(	(	PUNCT
ecj-12166	82	85	eol	eol	PROPN
ecj-12166	82	86	)	)	PUNCT
ecj-12166	82	87	and	and	CCONJ
ecj-12166	82	88	have	have	VERB
ecj-12166	82	89	uncontrolled	uncontrolled	ADJ
ecj-12166	82	90	pain	pain	NOUN
ecj-12166	82	91	,	,	PUNCT
ecj-12166	82	92	emergency	emergency	NOUN
ecj-12166	82	93	clinicians	clinician	NOUN
ecj-12166	82	94	should	should	AUX
ecj-12166	82	95	remember	remember	VERB
ecj-12166	82	96	to	to	PART
ecj-12166	82	97	use	use	VERB
ecj-12166	82	98	ketamine	ketamine	PROPN
ecj-12166	82	99	as	as	ADP
ecj-12166	82	100	a	a	DET
ecj-12166	82	101	painkiller	painkiller	NOUN
ecj-12166	82	102	and/or	and/or	CCONJ
ecj-12166	82	103	sedative	sedative	ADJ
ecj-12166	82	104	agent	agent	NOUN
ecj-12166	82	105	.	.	PUNCT
ecj-12166	83	1	as	as	SCONJ
ecj-12166	83	2	reported	report	VERB
ecj-12166	83	3	by	by	ADP
ecj-12166	83	4	serra	serra	PROPN
ecj-12166	83	5	et	et	PROPN
ecj-12166	83	6	al	al	PROPN
ecj-12166	83	7	.	.	PROPN
ecj-12166	83	8	,53	,53	PUNCT
ecj-12166	83	9	ketamine	ketamine	PROPN
ecj-12166	83	10	(	(	PUNCT
ecj-12166	83	11	iv	iv	NUM
ecj-12166	83	12	:	:	PUNCT
ecj-12166	83	13	0.1	0.1	NUM
ecj-12166	83	14	-	-	SYM
ecj-12166	83	15	0.3	0.3	NUM
ecj-12166	83	16	mg	mg	PROPN
ecj-12166	83	17	/	/	SYM
ecj-12166	83	18	kg	kg	PROPN
ecj-12166	83	19	bolus	bolus	NOUN
ecj-12166	83	20	;	;	PUNCT
ecj-12166	83	21	0.1	0.1	NUM
ecj-12166	83	22	-	-	SYM
ecj-12166	83	23	0.3	0.3	NUM
ecj-12166	83	24	mg	mg	PROPN
ecj-12166	83	25	/	/	SYM
ecj-12166	83	26	kg	kg	PROPN
ecj-12166	83	27	/	/	SYM
ecj-12166	83	28	h	h	NOUN
ecj-12166	83	29	via	via	ADP
ecj-12166	83	30	continuous	continuous	ADJ
ecj-12166	83	31	infusion	infusion	NOUN
ecj-12166	83	32	)	)	PUNCT
ecj-12166	83	33	may	may	AUX
ecj-12166	83	34	have	have	VERB
ecj-12166	83	35	a	a	DET
ecj-12166	83	36	role	role	NOUN
ecj-12166	83	37	in	in	ADP
ecj-12166	83	38	the	the	DET
ecj-12166	83	39	management	management	NOUN
ecj-12166	83	40	of	of	ADP
ecj-12166	83	41	pain	pain	NOUN
ecj-12166	83	42	unresponsive	unresponsive	ADJ
ecj-12166	83	43	to	to	ADP
ecj-12166	83	44	opioids	opioid	NOUN
ecj-12166	83	45	,	,	PUNCT
ecj-12166	83	46	in	in	ADP
ecj-12166	83	47	neuropathic	neuropathic	ADJ
ecj-12166	83	48	pain	pain	NOUN
ecj-12166	83	49	,	,	PUNCT
ecj-12166	83	50	in	in	ADP
ecj-12166	83	51	opioid	opioid	NOUN
ecj-12166	83	52	-	-	PUNCT
ecj-12166	83	53	induced	induce	VERB
ecj-12166	83	54	hyperalgesia	hyperalgesia	NOUN
ecj-12166	83	55	,	,	PUNCT
ecj-12166	83	56	and	and	CCONJ
ecj-12166	83	57	could	could	AUX
ecj-12166	83	58	also	also	ADV
ecj-12166	83	59	have	have	VERB
ecj-12166	83	60	a	a	DET
ecj-12166	83	61	future	future	ADJ
ecj-12166	83	62	role	role	NOUN
ecj-12166	83	63	in	in	ADP
ecj-12166	83	64	palliative	palliative	ADJ
ecj-12166	83	65	sedation	sedation	NOUN
ecj-12166	83	66	in	in	ADP
ecj-12166	83	67	the	the	DET
ecj-12166	83	68	eol.54	eol.54	PROPN
ecj-12166	83	69	ketamine	ketamine	PROPN
ecj-12166	83	70	shows	show	NOUN
ecj-12166	83	71	also	also	ADV
ecj-12166	83	72	potential	potential	ADJ
ecj-12166	83	73	as	as	ADP
ecj-12166	83	74	a	a	DET
ecj-12166	83	75	bronchodilator	bronchodilator	NOUN
ecj-12166	83	76	for	for	ADP
ecj-12166	83	77	pediatric	pediatric	ADJ
ecj-12166	83	78	patients	patient	NOUN
ecj-12166	83	79	with	with	ADP
ecj-12166	83	80	acute	acute	ADJ
ecj-12166	83	81	asthma	asthma	NOUN
ecj-12166	83	82	exacerbation	exacerbation	NOUN
ecj-12166	83	83	and	and	CCONJ
ecj-12166	83	84	has	have	AUX
ecj-12166	83	85	emerged	emerge	VERB
ecj-12166	83	86	as	as	ADP
ecj-12166	83	87	a	a	DET
ecj-12166	83	88	treatment	treatment	NOUN
ecj-12166	83	89	option	option	NOUN
ecj-12166	83	90	for	for	ADP
ecj-12166	83	91	pediatric	pediatric	ADJ
ecj-12166	83	92	patients	patient	NOUN
ecj-12166	83	93	with	with	ADP
ecj-12166	83	94	acute	acute	ADJ
ecj-12166	83	95	asthma	asthma	NOUN
ecj-12166	83	96	exacerbation	exacerbation	NOUN
ecj-12166	83	97	who	who	PRON
ecj-12166	83	98	do	do	AUX
ecj-12166	83	99	not	not	PART
ecj-12166	83	100	respond	respond	VERB
ecj-12166	83	101	to	to	ADP
ecj-12166	83	102	standard	standard	ADJ
ecj-12166	83	103	therapy	therapy	NOUN
ecj-12166	83	104	as	as	ADP
ecj-12166	83	105	a	a	DET
ecj-12166	83	106	temporizing	temporizing	ADJ
ecj-12166	83	107	measure	measure	NOUN
ecj-12166	83	108	to	to	PART
ecj-12166	83	109	prevent	prevent	VERB
ecj-12166	83	110	mechanical	mechanical	ADJ
ecj-12166	83	111	ventilation.55,56	ventilation.55,56	NOUN
ecj-12166	83	112	in	in	ADP
ecj-12166	83	113	the	the	DET
ecj-12166	83	114	review	review	NOUN
ecj-12166	83	115	by	by	ADP
ecj-12166	83	116	garner	garner	NOUN
ecj-12166	83	117	et	et	PROPN
ecj-12166	83	118	al	al	PROPN
ecj-12166	83	119	.	.	PROPN
ecj-12166	83	120	,57	,57	PUNCT
ecj-12166	84	1	the	the	DET
ecj-12166	84	2	authors	author	NOUN
ecj-12166	84	3	outline	outline	VERB
ecj-12166	84	4	strategies	strategy	NOUN
ecj-12166	84	5	for	for	ADP
ecj-12166	84	6	the	the	DET
ecj-12166	84	7	assessment	assessment	NOUN
ecj-12166	84	8	and	and	CCONJ
ecj-12166	84	9	management	management	NOUN
ecj-12166	84	10	of	of	ADP
ecj-12166	84	11	patients	patient	NOUN
ecj-12166	84	12	with	with	ADP
ecj-12166	84	13	acute	acute	ADJ
ecj-12166	84	14	life	life	NOUN
ecj-12166	84	15	-	-	PUNCT
ecj-12166	84	16	threatening	threaten	VERB
ecj-12166	84	17	asthma	asthma	NOUN
ecj-12166	84	18	focusing	focus	VERB
ecj-12166	84	19	on	on	ADP
ecj-12166	84	20	those	those	PRON
ecj-12166	84	21	requiring	require	VERB
ecj-12166	84	22	admission	admission	NOUN
ecj-12166	84	23	to	to	ADP
ecj-12166	84	24	the	the	DET
ecj-12166	84	25	icu	icu	PROPN
ecj-12166	84	26	and	and	CCONJ
ecj-12166	84	27	they	they	PRON
ecj-12166	84	28	suggest	suggest	VERB
ecj-12166	84	29	using	use	VERB
ecj-12166	84	30	ketamine	ketamine	PROPN
ecj-12166	84	31	or	or	CCONJ
ecj-12166	84	32	propofol	propofol	NOUN
ecj-12166	84	33	as	as	ADP
ecj-12166	84	34	sedative	sedative	ADJ
ecj-12166	84	35	agents	agent	NOUN
ecj-12166	84	36	for	for	ADP
ecj-12166	84	37	non	non	ADJ
ecj-12166	84	38	-	-	ADJ
ecj-12166	84	39	invasive	invasive	ADJ
ecj-12166	84	40	mechanical	mechanical	ADJ
ecj-12166	84	41	ventilation	ventilation	NOUN
ecj-12166	84	42	because	because	SCONJ
ecj-12166	84	43	of	of	ADP
ecj-12166	84	44	their	their	PRON
ecj-12166	84	45	potential	potential	ADJ
ecj-12166	84	46	bronchodilation	bronchodilation	NOUN
ecj-12166	84	47	properties	property	NOUN
ecj-12166	84	48	.	.	PUNCT
ecj-12166	85	1	finally	finally	ADV
ecj-12166	85	2	,	,	PUNCT
ecj-12166	85	3	ketamine	ketamine	PROPN
ecj-12166	85	4	is	be	AUX
ecj-12166	85	5	useful	useful	ADJ
ecj-12166	85	6	to	to	PART
ecj-12166	85	7	treat	treat	VERB
ecj-12166	85	8	refractory	refractory	NOUN
ecj-12166	85	9	status	status	NOUN
ecj-12166	85	10	epilepticus	epilepticus	VERB
ecj-12166	85	11	by	by	ADP
ecj-12166	85	12	antagonizing	antagonize	VERB
ecj-12166	85	13	nmda	nmda	ADJ
ecj-12166	85	14	receptors	receptor	NOUN
ecj-12166	85	15	and	and	CCONJ
ecj-12166	85	16	inhibiting	inhibit	VERB
ecj-12166	85	17	glutamatergic	glutamatergic	ADJ
ecj-12166	85	18	transmission.58	transmission.58	ADJ
ecj-12166	85	19	adverse	adverse	ADJ
ecj-12166	85	20	events	event	NOUN
ecj-12166	85	21	,	,	PUNCT
ecj-12166	85	22	drug	drug	NOUN
ecj-12166	85	23	-	-	PUNCT
ecj-12166	85	24	drug	drug	NOUN
ecj-12166	85	25	interactions	interaction	NOUN
ecj-12166	85	26	,	,	PUNCT
ecj-12166	85	27	and	and	CCONJ
ecj-12166	85	28	contraindications	contraindication	NOUN
ecj-12166	85	29	although	although	SCONJ
ecj-12166	85	30	ketamine	ketamine	PROPN
ecj-12166	85	31	is	be	AUX
ecj-12166	85	32	generally	generally	ADV
ecj-12166	85	33	considered	consider	VERB
ecj-12166	85	34	safe	safe	ADJ
ecj-12166	85	35	,	,	PUNCT
ecj-12166	85	36	it	it	PRON
ecj-12166	85	37	can	can	AUX
ecj-12166	85	38	cause	cause	VERB
ecj-12166	85	39	different	different	ADJ
ecj-12166	85	40	dose	dose	NOUN
ecj-12166	85	41	-	-	PUNCT
ecj-12166	85	42	dependent	dependent	ADJ
ecj-12166	85	43	side	side	NOUN
ecj-12166	85	44	effects	effect	NOUN
ecj-12166	85	45	and	and	CCONJ
ecj-12166	85	46	are	be	AUX
ecj-12166	85	47	most	most	ADV
ecj-12166	85	48	observed	observe	VERB
ecj-12166	85	49	at	at	ADP
ecj-12166	85	50	doses	dose	NOUN
ecj-12166	85	51	above	above	ADP
ecj-12166	85	52	0.35	0.35	NUM
ecj-12166	85	53	mg	mg	PROPN
ecj-12166	85	54	/	/	SYM
ecj-12166	85	55	kg	kg	PROPN
ecj-12166	85	56	(	(	PUNCT
ecj-12166	85	57	especially	especially	ADV
ecj-12166	85	58	at	at	ADP
ecj-12166	85	59	doses	dose	NOUN
ecj-12166	85	60	between	between	ADP
ecj-12166	85	61	0.4	0.4	NUM
ecj-12166	85	62	and	and	CCONJ
ecj-12166	85	63	0.7	0.7	NUM
ecj-12166	85	64	mg	mg	PROPN
ecj-12166	85	65	/	/	SYM
ecj-12166	85	66	kg).2	kg).2	PROPN
ecj-12166	85	67	at	at	ADP
ecj-12166	85	68	lower	low	ADJ
ecj-12166	85	69	doses	dose	NOUN
ecj-12166	85	70	it	it	PRON
ecj-12166	85	71	can	can	AUX
ecj-12166	85	72	cause	cause	VERB
ecj-12166	85	73	dreamy	dreamy	ADJ
ecj-12166	85	74	thinking	thinking	NOUN
ecj-12166	85	75	,	,	PUNCT
ecj-12166	85	76	alterations	alteration	NOUN
ecj-12166	85	77	of	of	ADP
ecj-12166	85	78	speech	speech	NOUN
ecj-12166	85	79	,	,	PUNCT
ecj-12166	85	80	hearing	hearing	NOUN
ecj-12166	85	81	and	and	CCONJ
ecj-12166	85	82	seeing	see	VERB
ecj-12166	85	83	,	,	PUNCT
ecj-12166	85	84	muscular	muscular	ADJ
ecj-12166	85	85	discoordination	discoordination	NOUN
ecj-12166	85	86	,	,	PUNCT
ecj-12166	85	87	disorientation	disorientation	NOUN
ecj-12166	85	88	,	,	PUNCT
ecj-12166	85	89	anxiety	anxiety	NOUN
ecj-12166	85	90	,	,	PUNCT
ecj-12166	85	91	disinhibition	disinhibition	NOUN
ecj-12166	85	92	,	,	PUNCT
ecj-12166	85	93	euphoria	euphoria	NOUN
ecj-12166	85	94	,	,	PUNCT
ecj-12166	85	95	seeing	see	VERB
ecj-12166	85	96	the	the	DET
ecj-12166	85	97	world	world	NOUN
ecj-12166	85	98	differently	differently	ADV
ecj-12166	85	99	,	,	PUNCT
ecj-12166	85	100	and	and	CCONJ
ecj-12166	85	101	irrational	irrational	ADJ
ecj-12166	85	102	behavior;2,59	behavior;2,59	NOUN
ecj-12166	85	103	higher	high	ADJ
ecj-12166	85	104	doses	dose	NOUN
ecj-12166	85	105	can	can	AUX
ecj-12166	85	106	cause	cause	VERB
ecj-12166	85	107	great	great	ADJ
ecj-12166	85	108	difficulty	difficulty	NOUN
ecj-12166	85	109	in	in	ADP
ecj-12166	85	110	moving	move	VERB
ecj-12166	85	111	,	,	PUNCT
ecj-12166	85	112	seizures	seizure	NOUN
ecj-12166	85	113	,	,	PUNCT
ecj-12166	85	114	nausea	nausea	NOUN
ecj-12166	85	115	,	,	PUNCT
ecj-12166	85	116	and	and	CCONJ
ecj-12166	85	117	vomiting	vomiting	NOUN
ecj-12166	85	118	;	;	PUNCT
ecj-12166	85	119	extreme	extreme	ADJ
ecj-12166	85	120	doses	dose	NOUN
ecj-12166	85	121	can	can	AUX
ecj-12166	85	122	produce	produce	VERB
ecj-12166	85	123	complete	complete	ADJ
ecj-12166	85	124	dissociation	dissociation	NOUN
ecj-12166	85	125	from	from	ADP
ecj-12166	85	126	reality	reality	NOUN
ecj-12166	85	127	and	and	CCONJ
ecj-12166	85	128	loss	loss	NOUN
ecj-12166	85	129	of	of	ADP
ecj-12166	85	130	consciousness	consciousness	NOUN
ecj-12166	85	131	,	,	PUNCT
ecj-12166	85	132	hallucinations	hallucination	NOUN
ecj-12166	85	133	,	,	PUNCT
ecj-12166	85	134	out	out	ADV
ecj-12166	85	135	-	-	PUNCT
ecj-12166	85	136	of	of	ADP
ecj-12166	85	137	-	-	PUNCT
ecj-12166	85	138	body	body	NOUN
ecj-12166	85	139	experiences	experience	NOUN
ecj-12166	85	140	,	,	PUNCT
ecj-12166	85	141	and	and	CCONJ
ecj-12166	85	142	so	so	ADV
ecj-12166	85	143	-	-	PUNCT
ecj-12166	85	144	called	call	VERB
ecj-12166	85	145	“	"	PUNCT
ecj-12166	85	146	neardeath	neardeath	ADJ
ecj-12166	85	147	experiences	experience	NOUN
ecj-12166	85	148	”	"	PUNCT
ecj-12166	85	149	or	or	CCONJ
ecj-12166	85	150	the	the	DET
ecj-12166	85	151	“	"	PUNCT
ecj-12166	85	152	k	k	ADJ
ecj-12166	85	153	-	-	NOUN
ecj-12166	85	154	hole	hole	NOUN
ecj-12166	85	155	”	"	PUNCT
ecj-12166	85	156	.	.	PUNCT
ecj-12166	86	1	these	these	DET
ecj-12166	86	2	side	side	NOUN
ecj-12166	86	3	effects	effect	NOUN
ecj-12166	86	4	can	can	AUX
ecj-12166	86	5	be	be	AUX
ecj-12166	86	6	well	well	ADV
ecj-12166	86	7	controlled	control	VERB
ecj-12166	86	8	by	by	ADP
ecj-12166	86	9	benzodiazepines,60	benzodiazepines,60	NUM
ecj-12166	86	10	such	such	ADJ
ecj-12166	86	11	as	as	ADP
ecj-12166	86	12	diazepam	diazepam	NOUN
ecj-12166	86	13	,	,	PUNCT
ecj-12166	86	14	bromazepam	bromazepam	NOUN
ecj-12166	86	15	,	,	PUNCT
ecj-12166	86	16	or	or	CCONJ
ecj-12166	86	17	midazolam	midazolam	PROPN
ecj-12166	86	18	,	,	PUNCT
ecj-12166	86	19	and	and	CCONJ
ecj-12166	86	20	they	they	PRON
ecj-12166	86	21	usually	usually	ADV
ecj-12166	86	22	disappear	disappear	VERB
ecj-12166	86	23	within	within	ADP
ecj-12166	86	24	30	30	NUM
ecj-12166	86	25	min	min	NOUN
ecj-12166	86	26	after	after	ADP
ecj-12166	86	27	the	the	DET
ecj-12166	86	28	first	first	ADJ
ecj-12166	86	29	dose	dose	NOUN
ecj-12166	86	30	,	,	PUNCT
ecj-12166	86	31	especially	especially	ADV
ecj-12166	86	32	at	at	ADP
ecj-12166	86	33	high	high	ADJ
ecj-12166	86	34	doses	dose	NOUN
ecj-12166	86	35	,	,	PUNCT
ecj-12166	86	36	or	or	CCONJ
ecj-12166	86	37	after	after	SCONJ
ecj-12166	86	38	the	the	DET
ecj-12166	86	39	start	start	NOUN
ecj-12166	86	40	of	of	ADP
ecj-12166	86	41	a	a	DET
ecj-12166	86	42	continuous	continuous	ADJ
ecj-12166	86	43	infusion.2	infusion.2	PROPN
ecj-12166	86	44	nausea	nausea	NOUN
ecj-12166	86	45	and	and	CCONJ
ecj-12166	86	46	vomiting	vomiting	NOUN
ecj-12166	86	47	can	can	AUX
ecj-12166	86	48	be	be	AUX
ecj-12166	86	49	adequately	adequately	ADV
ecj-12166	86	50	controlled	control	VERB
ecj-12166	86	51	with	with	ADP
ecj-12166	86	52	ondansetron	ondansetron	NOUN
ecj-12166	86	53	.	.	PUNCT
ecj-12166	87	1	other	other	ADJ
ecj-12166	87	2	side	side	NOUN
ecj-12166	87	3	effects	effect	NOUN
ecj-12166	87	4	are	be	AUX
ecj-12166	87	5	sialorrhea	sialorrhea	ADJ
ecj-12166	87	6	(	(	PUNCT
ecj-12166	87	7	treated	treat	VERB
ecj-12166	87	8	with	with	ADP
ecj-12166	87	9	atropine	atropine	NOUN
ecj-12166	87	10	0.5	0.5	NUM
ecj-12166	87	11	mg	mg	NUM
ecj-12166	87	12	iv	iv	PROPN
ecj-12166	87	13	)	)	PUNCT
ecj-12166	87	14	and	and	CCONJ
ecj-12166	87	15	very	very	ADV
ecj-12166	87	16	rarely	rarely	ADV
ecj-12166	87	17	laryngospasm.61	laryngospasm.61	ADJ
ecj-12166	87	18	laryngospasm	laryngospasm	NOUN
ecj-12166	87	19	occurs	occur	VERB
ecj-12166	87	20	more	more	ADV
ecj-12166	87	21	frequently	frequently	ADV
ecj-12166	87	22	and	and	CCONJ
ecj-12166	87	23	with	with	ADP
ecj-12166	87	24	greater	great	ADJ
ecj-12166	87	25	severity	severity	NOUN
ecj-12166	87	26	in	in	ADP
ecj-12166	87	27	pediatric	pediatric	ADJ
ecj-12166	87	28	patients	patient	NOUN
ecj-12166	87	29	.	.	PUNCT
ecj-12166	88	1	in	in	ADP
ecj-12166	88	2	one	one	NUM
ecj-12166	88	3	meta	meta	ADJ
ecj-12166	88	4	-	-	PUNCT
ecj-12166	88	5	analysis	analysis	NOUN
ecj-12166	88	6	,	,	PUNCT
ecj-12166	88	7	adults	adult	NOUN
ecj-12166	88	8	have	have	VERB
ecj-12166	88	9	an	an	DET
ecj-12166	88	10	incidence	incidence	NOUN
ecj-12166	88	11	of	of	ADP
ecj-12166	88	12	4.2	4.2	NUM
ecj-12166	88	13	per	per	ADP
ecj-12166	88	14	1000	1000	NUM
ecj-12166	88	15	.	.	PUNCT
ecj-12166	89	1	children	child	NOUN
ecj-12166	89	2	up	up	ADP
ecj-12166	89	3	to	to	ADP
ecj-12166	89	4	the	the	DET
ecj-12166	89	5	age	age	NOUN
ecj-12166	89	6	of	of	ADP
ecj-12166	89	7	9	9	NUM
ecj-12166	89	8	years	year	NOUN
ecj-12166	89	9	have	have	VERB
ecj-12166	89	10	an	an	DET
ecj-12166	89	11	incidence	incidence	NOUN
ecj-12166	89	12	of	of	ADP
ecj-12166	89	13	17	17	NUM
ecj-12166	89	14	in	in	ADP
ecj-12166	89	15	1000	1000	NUM
ecj-12166	89	16	cases	case	NOUN
ecj-12166	89	17	.	.	PUNCT
ecj-12166	90	1	children	child	NOUN
ecj-12166	90	2	between	between	ADP
ecj-12166	90	3	3	3	NUM
ecj-12166	90	4	and	and	CCONJ
ecj-12166	90	5	6	6	NUM
ecj-12166	90	6	months	month	NOUN
ecj-12166	90	7	have	have	VERB
ecj-12166	90	8	an	an	DET
ecj-12166	90	9	incidence	incidence	NOUN
ecj-12166	90	10	three	three	NUM
ecj-12166	90	11	times	time	NOUN
ecj-12166	90	12	greater.62	greater.62	PROPN
ecj-12166	90	13	laryngospasm	laryngospasm	PROPN
ecj-12166	90	14	is	be	AUX
ecj-12166	90	15	a	a	DET
ecj-12166	90	16	life	life	NOUN
ecj-12166	90	17	-	-	PUNCT
ecj-12166	90	18	threatening	threaten	VERB
ecj-12166	90	19	condition	condition	NOUN
ecj-12166	90	20	that	that	PRON
ecj-12166	90	21	requires	require	VERB
ecj-12166	90	22	prompt	prompt	ADJ
ecj-12166	90	23	recognition	recognition	NOUN
ecj-12166	90	24	and	and	CCONJ
ecj-12166	90	25	treatment	treatment	NOUN
ecj-12166	90	26	to	to	PART
ecj-12166	90	27	avoid	avoid	VERB
ecj-12166	90	28	morbidity	morbidity	NOUN
ecj-12166	90	29	and	and	CCONJ
ecj-12166	90	30	mortality	mortality	NOUN
ecj-12166	90	31	.	.	PUNCT
ecj-12166	91	1	since	since	SCONJ
ecj-12166	91	2	ketamine	ketamine	NOUN
ecj-12166	91	3	-	-	PUNCT
ecj-12166	91	4	associated	associate	VERB
ecj-12166	91	5	laryngospasm	laryngospasm	NOUN
ecj-12166	91	6	seems	seem	VERB
ecj-12166	91	7	to	to	PART
ecj-12166	91	8	be	be	AUX
ecj-12166	91	9	idiosyncratic	idiosyncratic	ADJ
ecj-12166	91	10	and	and	CCONJ
ecj-12166	91	11	without	without	ADP
ecj-12166	91	12	evidence	evidence	NOUN
ecj-12166	91	13	of	of	ADP
ecj-12166	91	14	correlation	correlation	NOUN
ecj-12166	91	15	with	with	ADP
ecj-12166	91	16	age	age	NOUN
ecj-12166	91	17	,	,	PUNCT
ecj-12166	91	18	dose	dose	NOUN
ecj-12166	91	19	,	,	PUNCT
ecj-12166	91	20	or	or	CCONJ
ecj-12166	91	21	other	other	ADJ
ecj-12166	91	22	clinical	clinical	ADJ
ecj-12166	91	23	variables	variable	NOUN
ecj-12166	91	24	,	,	PUNCT
ecj-12166	91	25	emergency	emergency	NOUN
ecj-12166	91	26	clinicians	clinician	NOUN
ecj-12166	91	27	administering	administer	VERB
ecj-12166	91	28	ketamine	ketamine	PROPN
ecj-12166	91	29	must	must	AUX
ecj-12166	91	30	be	be	AUX
ecj-12166	91	31	prepared	prepare	VERB
ecj-12166	91	32	for	for	ADP
ecj-12166	91	33	its	its	PRON
ecj-12166	91	34	rapid	rapid	ADJ
ecj-12166	91	35	identification	identification	NOUN
ecj-12166	91	36	and	and	CCONJ
ecj-12166	91	37	management.63	management.63	NOUN
ecj-12166	91	38	a	a	DET
ecj-12166	91	39	unique	unique	ADJ
ecj-12166	91	40	case	case	NOUN
ecj-12166	91	41	of	of	ADP
ecj-12166	91	42	opisthotonos	opisthotonos	PROPN
ecj-12166	91	43	has	have	AUX
ecj-12166	91	44	been	be	AUX
ecj-12166	91	45	reported	report	VERB
ecj-12166	91	46	after	after	ADP
ecj-12166	91	47	the	the	DET
ecj-12166	91	48	administration	administration	NOUN
ecj-12166	91	49	of	of	ADP
ecj-12166	91	50	250	250	NUM
ecj-12166	91	51	mg	mg	PROPN
ecj-12166	91	52	intramuscular	intramuscular	ADJ
ecj-12166	91	53	ketamine	ketamine	PROPN
ecj-12166	91	54	by	by	ADP
ecj-12166	91	55	paramedics	paramedic	NOUN
ecj-12166	91	56	in	in	ADP
ecj-12166	91	57	a	a	DET
ecj-12166	91	58	24	24	NUM
ecj-12166	91	59	-	-	PUNCT
ecj-12166	91	60	year	year	NOUN
ecj-12166	91	61	-	-	PUNCT
ecj-12166	91	62	old	old	ADJ
ecj-12166	91	63	male	male	ADJ
ecj-12166	91	64	patient	patient	NOUN
ecj-12166	91	65	with	with	ADP
ecj-12166	91	66	a	a	DET
ecj-12166	91	67	history	history	NOUN
ecj-12166	91	68	of	of	ADP
ecj-12166	91	69	schizophrenia	schizophrenia	NOUN
ecj-12166	91	70	to	to	PART
ecj-12166	91	71	control	control	VERB
ecj-12166	91	72	severe	severe	ADJ
ecj-12166	91	73	agitation.64	agitation.64	PROPN
ecj-12166	91	74	opisthotonos	opisthotonos	PROPN
ecj-12166	91	75	was	be	AUX
ecj-12166	91	76	completely	completely	ADV
ecj-12166	91	77	solved	solve	VERB
ecj-12166	91	78	after	after	ADP
ecj-12166	91	79	intravenous	intravenous	ADJ
ecj-12166	91	80	midazolam	midazolam	PROPN
ecj-12166	91	81	(	(	PUNCT
ecj-12166	91	82	2	2	NUM
ecj-12166	91	83	consecutive	consecutive	ADJ
ecj-12166	91	84	boluses	bolus	NOUN
ecj-12166	91	85	of	of	ADP
ecj-12166	91	86	2.5	2.5	NUM
ecj-12166	91	87	mg	mg	NUM
ecj-12166	91	88	iv	iv	NUM
ecj-12166	91	89	)	)	PUNCT
ecj-12166	91	90	and	and	CCONJ
ecj-12166	91	91	probably	probably	ADV
ecj-12166	91	92	related	relate	VERB
ecj-12166	91	93	to	to	ADP
ecj-12166	91	94	the	the	DET
ecj-12166	91	95	sub	sub	ADJ
ecj-12166	91	96	-	-	ADJ
ecj-12166	91	97	dissociative	dissociative	ADJ
ecj-12166	91	98	dose	dose	NOUN
ecj-12166	91	99	.	.	PUNCT
ecj-12166	92	1	no	no	DET
ecj-12166	92	2	medical	medical	ADJ
ecj-12166	92	3	deaths	death	NOUN
ecj-12166	92	4	from	from	ADP
ecj-12166	92	5	ketamine	ketamine	PROPN
ecj-12166	92	6	are	be	AUX
ecj-12166	92	7	reported	report	VERB
ecj-12166	92	8	in	in	ADP
ecj-12166	92	9	the	the	DET
ecj-12166	92	10	literature	literature	NOUN
ecj-12166	92	11	,	,	PUNCT
ecj-12166	92	12	probably	probably	ADV
ecj-12166	92	13	due	due	ADP
ecj-12166	92	14	to	to	ADP
ecj-12166	92	15	the	the	DET
ecj-12166	92	16	very	very	ADV
ecj-12166	92	17	wide	wide	ADJ
ecj-12166	92	18	therapeutic	therapeutic	ADJ
ecj-12166	92	19	range	range	NOUN
ecj-12166	92	20	of	of	ADP
ecj-12166	92	21	ketamine	ketamine	NOUN
ecj-12166	92	22	.	.	PUNCT
ecj-12166	93	1	the	the	DET
ecj-12166	93	2	lethal	lethal	ADJ
ecj-12166	93	3	dose	dose	NOUN
ecj-12166	93	4	of	of	ADP
ecj-12166	93	5	ketamine	ketamine	PROPN
ecj-12166	93	6	is	be	AUX
ecj-12166	93	7	about	about	ADV
ecj-12166	93	8	60	60	NUM
ecj-12166	93	9	mg	mg	NUM
ecj-12166	93	10	/	/	SYM
ecj-12166	93	11	kg.48	kg.48	PROPN
ecj-12166	93	12	ketamine	ketamine	PROPN
ecj-12166	93	13	inhibits	inhibit	VERB
ecj-12166	93	14	the	the	DET
ecj-12166	93	15	reuptake	reuptake	NOUN
ecj-12166	93	16	of	of	ADP
ecj-12166	93	17	catecholamines	catecholamine	NOUN
ecj-12166	93	18	leading	lead	VERB
ecj-12166	93	19	to	to	ADP
ecj-12166	93	20	a	a	DET
ecj-12166	93	21	modest	modest	ADJ
ecj-12166	93	22	increase	increase	NOUN
ecj-12166	93	23	in	in	ADP
ecj-12166	93	24	blood	blood	NOUN
ecj-12166	93	25	pressure	pressure	NOUN
ecj-12166	93	26	and	and	CCONJ
ecj-12166	93	27	heart	heart	NOUN
ecj-12166	93	28	rate	rate	NOUN
ecj-12166	93	29	,	,	PUNCT
ecj-12166	93	30	through	through	ADP
ecj-12166	93	31	sympathetic	sympathetic	ADJ
ecj-12166	93	32	activation.65	activation.65	ADV
ecj-12166	93	33	even	even	ADV
ecj-12166	93	34	if	if	SCONJ
ecj-12166	93	35	the	the	DET
ecj-12166	93	36	stimulation	stimulation	NOUN
ecj-12166	93	37	of	of	ADP
ecj-12166	93	38	cardiac	cardiac	ADJ
ecj-12166	93	39	output	output	NOUN
ecj-12166	93	40	is	be	AUX
ecj-12166	93	41	considered	consider	VERB
ecj-12166	93	42	an	an	DET
ecj-12166	93	43	advantage	advantage	NOUN
ecj-12166	93	44	in	in	ADP
ecj-12166	93	45	the	the	DET
ecj-12166	93	46	case	case	NOUN
ecj-12166	93	47	of	of	ADP
ecj-12166	93	48	a	a	DET
ecj-12166	93	49	hypotensive	hypotensive	ADJ
ecj-12166	93	50	patient,66	patient,66	NOUN
ecj-12166	93	51	and	and	CCONJ
ecj-12166	93	52	it	it	PRON
ecj-12166	93	53	usually	usually	ADV
ecj-12166	93	54	does	do	AUX
ecj-12166	93	55	not	not	PART
ecj-12166	93	56	impair	impair	VERB
ecj-12166	93	57	airway	airway	NOUN
ecj-12166	93	58	maintenance	maintenance	NOUN
ecj-12166	93	59	and	and	CCONJ
ecj-12166	93	60	spontaneous	spontaneous	ADJ
ecj-12166	93	61	respiration	respiration	NOUN
ecj-12166	93	62	,	,	PUNCT
ecj-12166	93	63	caution	caution	NOUN
ecj-12166	93	64	must	must	AUX
ecj-12166	93	65	be	be	AUX
ecj-12166	93	66	maintained	maintain	VERB
ecj-12166	93	67	in	in	ADP
ecj-12166	93	68	patients	patient	NOUN
ecj-12166	93	69	with	with	ADP
ecj-12166	93	70	severe	severe	ADJ
ecj-12166	93	71	and	and	CCONJ
ecj-12166	93	72	uncontrolled	uncontrolled	ADJ
ecj-12166	93	73	hypertension	hypertension	NOUN
ecj-12166	93	74	and/or	and/or	CCONJ
ecj-12166	93	75	persistent	persistent	ADJ
ecj-12166	93	76	cardiovascular	cardiovascular	ADJ
ecj-12166	93	77	diseases.4,26,50	diseases.4,26,50	NOUN
ecj-12166	93	78	ecg	ecg	PROPN
ecj-12166	93	79	monitoring	monitoring	NOUN
ecj-12166	93	80	before	before	ADV
ecj-12166	93	81	and	and	CCONJ
ecj-12166	93	82	,	,	PUNCT
ecj-12166	93	83	if	if	SCONJ
ecj-12166	93	84	necessary	necessary	ADJ
ecj-12166	93	85	,	,	PUNCT
ecj-12166	93	86	during	during	SCONJ
ecj-12166	93	87	administration	administration	NOUN
ecj-12166	93	88	is	be	AUX
ecj-12166	93	89	recommended	recommend	VERB
ecj-12166	93	90	,	,	PUNCT
ecj-12166	93	91	as	as	SCONJ
ecj-12166	93	92	is	be	AUX
ecj-12166	93	93	blood	blood	NOUN
ecj-12166	93	94	pressure	pressure	NOUN
ecj-12166	93	95	monitoring	monitoring	NOUN
ecj-12166	93	96	before	before	ADV
ecj-12166	93	97	and	and	CCONJ
ecj-12166	93	98	,	,	PUNCT
ecj-12166	93	99	at	at	ADP
ecj-12166	93	100	intervals	interval	NOUN
ecj-12166	93	101	during	during	ADP
ecj-12166	93	102	treatment	treatment	NOUN
ecj-12166	93	103	.	.	PUNCT
ecj-12166	94	1	ketamine	ketamine	PROPN
ecj-12166	94	2	administration	administration	PROPN
ecj-12166	94	3	is	be	AUX
ecj-12166	94	4	contraindicated	contraindicate	VERB
ecj-12166	94	5	in	in	ADP
ecj-12166	94	6	the	the	DET
ecj-12166	94	7	first	first	ADJ
ecj-12166	94	8	three	three	NUM
ecj-12166	94	9	months	month	NOUN
ecj-12166	94	10	of	of	ADP
ecj-12166	94	11	life,17	life,17	NOUN
ecj-12166	94	12	during	during	ADP
ecj-12166	94	13	pregnancy,49	pregnancy,49	NOUN
ecj-12166	94	14	and	and	CCONJ
ecj-12166	94	15	in	in	ADP
ecj-12166	94	16	patients	patient	NOUN
ecj-12166	94	17	affected	affect	VERB
ecj-12166	94	18	by	by	ADP
ecj-12166	94	19	hepatic	hepatic	ADJ
ecj-12166	94	20	porphyria.67	porphyria.67	NOUN
ecj-12166	94	21	conclusions	conclusion	NOUN
ecj-12166	94	22	our	our	PRON
ecj-12166	94	23	experience	experience	NOUN
ecj-12166	94	24	confirms	confirm	VERB
ecj-12166	94	25	that	that	SCONJ
ecj-12166	94	26	ketamine	ketamine	PROPN
ecj-12166	94	27	is	be	AUX
ecj-12166	94	28	a	a	DET
ecj-12166	94	29	safe	safe	ADJ
ecj-12166	94	30	drug	drug	NOUN
ecj-12166	94	31	that	that	PRON
ecj-12166	94	32	can	can	AUX
ecj-12166	94	33	be	be	AUX
ecj-12166	94	34	used	use	VERB
ecj-12166	94	35	for	for	ADP
ecj-12166	94	36	multiple	multiple	ADJ
ecj-12166	94	37	purposes	purpose	NOUN
ecj-12166	94	38	.	.	PUNCT
ecj-12166	95	1	our	our	PRON
ecj-12166	95	2	case	case	NOUN
ecj-12166	95	3	studies	study	NOUN
ecj-12166	95	4	cover	cover	VERB
ecj-12166	95	5	a	a	DET
ecj-12166	95	6	variety	variety	NOUN
ecj-12166	95	7	of	of	ADP
ecj-12166	95	8	mini	mini	ADJ
ecj-12166	95	9	review	review	NOUN
ecj-12166	95	10	[	[	X
ecj-12166	95	11	emergency	emergency	NOUN
ecj-12166	95	12	care	care	NOUN
ecj-12166	95	13	journal	journal	PROPN
ecj-12166	95	14	2024	2024	NUM
ecj-12166	95	15	;	;	PUNCT
ecj-12166	95	16	20:12166	20:12166	NUM
ecj-12166	95	17	]	]	X
ecj-12166	96	1	[	[	X
ecj-12166	96	2	page	page	NOUN
ecj-12166	96	3	33	33	NUM
ecj-12166	96	4	]	]	PUNCT
ecj-12166	96	5	non	non	ADJ
ecj-12166	96	6	-co	-co	PROPN
ecj-12166	96	7	mmerc	mmerc	PROPN
ecj-12166	96	8	ial	ial	PROPN
ecj-12166	96	9	us	us	PROPN
ecj-12166	96	10	e	e	NOUN
ecj-12166	96	11	o	o	NOUN
ecj-12166	96	12	nly	nly	ADV
ecj-12166	96	13	indications	indication	NOUN
ecj-12166	96	14	for	for	ADP
ecj-12166	96	15	ketamine	ketamine	NOUN
ecj-12166	96	16	in	in	ADP
ecj-12166	96	17	the	the	DET
ecj-12166	96	18	ed	ed	NOUN
ecj-12166	96	19	,	,	PUNCT
ecj-12166	96	20	such	such	ADJ
ecj-12166	96	21	as	as	ADP
ecj-12166	96	22	treating	treat	VERB
ecj-12166	96	23	delirium	delirium	NOUN
ecj-12166	96	24	tremens	tremen	NOUN
ecj-12166	96	25	in	in	ADP
ecj-12166	96	26	cases	case	NOUN
ecj-12166	96	27	of	of	ADP
ecj-12166	96	28	aws	aw	NOUN
ecj-12166	96	29	at	at	ADP
ecj-12166	96	30	a	a	DET
ecj-12166	96	31	sub	sub	ADJ
ecj-12166	96	32	-	-	ADJ
ecj-12166	96	33	dissociative	dissociative	ADJ
ecj-12166	96	34	dose	dose	NOUN
ecj-12166	96	35	,	,	PUNCT
ecj-12166	96	36	controlling	control	VERB
ecj-12166	96	37	psychomotor	psychomotor	NOUN
ecj-12166	96	38	acute	acute	NOUN
ecj-12166	96	39	agitation	agitation	NOUN
ecj-12166	96	40	due	due	ADP
ecj-12166	96	41	to	to	ADP
ecj-12166	96	42	substance	substance	NOUN
ecj-12166	96	43	use	use	NOUN
ecj-12166	96	44	disorder	disorder	NOUN
ecj-12166	96	45	or	or	CCONJ
ecj-12166	96	46	psychotic	psychotic	ADJ
ecj-12166	96	47	delirium	delirium	NOUN
ecj-12166	96	48	at	at	ADP
ecj-12166	96	49	a	a	DET
ecj-12166	96	50	dissociative	dissociative	ADJ
ecj-12166	96	51	dose	dose	NOUN
ecj-12166	96	52	,	,	PUNCT
ecj-12166	96	53	and	and	CCONJ
ecj-12166	96	54	managing	manage	VERB
ecj-12166	96	55	pain	pain	NOUN
ecj-12166	96	56	as	as	ADP
ecj-12166	96	57	a	a	DET
ecj-12166	96	58	valid	valid	ADJ
ecj-12166	96	59	opioid	opioid	ADJ
ecj-12166	96	60	alternative	alternative	NOUN
ecj-12166	96	61	.	.	PUNCT
ecj-12166	97	1	all	all	PRON
ecj-12166	97	2	of	of	ADP
ecj-12166	97	3	the	the	DET
ecj-12166	97	4	patients	patient	NOUN
ecj-12166	97	5	were	be	AUX
ecj-12166	97	6	successfully	successfully	ADV
ecj-12166	97	7	treated	treat	VERB
ecj-12166	97	8	by	by	ADP
ecj-12166	97	9	emergency	emergency	NOUN
ecj-12166	97	10	clinicians	clinician	NOUN
ecj-12166	97	11	,	,	PUNCT
ecj-12166	97	12	avoiding	avoid	VERB
ecj-12166	97	13	fatal	fatal	ADJ
ecj-12166	97	14	outcomes	outcome	NOUN
ecj-12166	97	15	in	in	ADP
ecj-12166	97	16	the	the	DET
ecj-12166	97	17	case	case	NOUN
ecj-12166	97	18	of	of	ADP
ecj-12166	97	19	bdzresistant	bdzresistant	ADJ
ecj-12166	97	20	aws	aw	NOUN
ecj-12166	97	21	,	,	PUNCT
ecj-12166	97	22	and	and	CCONJ
ecj-12166	97	23	ensuring	ensure	VERB
ecj-12166	97	24	good	good	ADJ
ecj-12166	97	25	pain	pain	NOUN
ecj-12166	97	26	control	control	NOUN
ecj-12166	97	27	in	in	ADP
ecj-12166	97	28	the	the	DET
ecj-12166	97	29	other	other	ADJ
ecj-12166	97	30	cases	case	NOUN
ecj-12166	97	31	.	.	PUNCT
ecj-12166	98	1	as	as	ADP
ecj-12166	98	2	a	a	DET
ecj-12166	98	3	result	result	NOUN
ecj-12166	98	4	,	,	PUNCT
ecj-12166	98	5	we	we	PRON
ecj-12166	98	6	strongly	strongly	ADV
ecj-12166	98	7	recommend	recommend	VERB
ecj-12166	98	8	emergency	emergency	NOUN
ecj-12166	98	9	clinicians	clinician	NOUN
ecj-12166	98	10	consider	consider	VERB
ecj-12166	98	11	ketamine	ketamine	NOUN
ecj-12166	98	12	as	as	ADP
ecj-12166	98	13	a	a	DET
ecj-12166	98	14	valid	valid	ADJ
ecj-12166	98	15	option	option	NOUN
ecj-12166	98	16	for	for	ADP
ecj-12166	98	17	pain	pain	NOUN
ecj-12166	98	18	management	management	NOUN
ecj-12166	98	19	and	and	CCONJ
ecj-12166	98	20	acute	acute	ADJ
ecj-12166	98	21	agitation	agitation	NOUN
ecj-12166	98	22	treatment	treatment	NOUN
ecj-12166	98	23	in	in	ADP
ecj-12166	98	24	cases	case	NOUN
ecj-12166	98	25	of	of	ADP
ecj-12166	98	26	alcohol	alcohol	NOUN
ecj-12166	98	27	withdrawal	withdrawal	NOUN
ecj-12166	98	28	syndrome	syndrome	NOUN
ecj-12166	98	29	and	and	CCONJ
ecj-12166	98	30	substance	substance	NOUN
ecj-12166	98	31	use	use	NOUN
ecj-12166	98	32	disorders	disorder	NOUN
ecj-12166	98	33	.	.	PUNCT
ecj-12166	99	1	references	reference	NOUN
ecj-12166	99	2	1	1	NUM
ecj-12166	99	3	.	.	PUNCT
ecj-12166	99	4	dinis	dinis	PROPN
ecj-12166	99	5	-	-	PUNCT
ecj-12166	99	6	oliveira	oliveira	PROPN
ecj-12166	99	7	rj	rj	PROPN
ecj-12166	99	8	.	.	PUNCT
ecj-12166	99	9	metabolism	metabolism	NOUN
ecj-12166	99	10	and	and	CCONJ
ecj-12166	99	11	metabolomics	metabolomic	NOUN
ecj-12166	99	12	of	of	ADP
ecj-12166	99	13	ketamine	ketamine	NOUN
ecj-12166	99	14	:	:	PUNCT
ecj-12166	99	15	a	a	DET
ecj-12166	99	16	toxicological	toxicological	ADJ
ecj-12166	99	17	approach	approach	NOUN
ecj-12166	99	18	.	.	PUNCT
ecj-12166	100	1	forensic	forensic	ADJ
ecj-12166	100	2	sci	sci	PROPN
ecj-12166	100	3	res	re	NOUN
ecj-12166	100	4	2017;2:2	2017;2:2	NOUN
ecj-12166	100	5	-	-	SYM
ecj-12166	100	6	10	10	NUM
ecj-12166	100	7	.	.	PUNCT
ecj-12166	101	1	2	2	X
ecj-12166	101	2	.	.	X
ecj-12166	101	3	riccardi	riccardi	VERB
ecj-12166	101	4	a	a	PRON
ecj-12166	101	5	,	,	PUNCT
ecj-12166	101	6	guarino	guarino	PROPN
ecj-12166	101	7	m	m	PROPN
ecj-12166	101	8	,	,	PUNCT
ecj-12166	101	9	serra	serra	PROPN
ecj-12166	101	10	s	s	PROPN
ecj-12166	101	11	,	,	PUNCT
ecj-12166	101	12	et	et	PROPN
ecj-12166	101	13	al	al	PROPN
ecj-12166	101	14	.	.	PROPN
ecj-12166	101	15	narrative	narrative	PROPN
ecj-12166	101	16	review	review	PROPN
ecj-12166	101	17	:	:	PUNCT
ecj-12166	101	18	lowdose	lowdose	PROPN
ecj-12166	101	19	ketamine	ketamine	PROPN
ecj-12166	101	20	for	for	ADP
ecj-12166	101	21	pain	pain	NOUN
ecj-12166	101	22	management	management	NOUN
ecj-12166	101	23	.	.	PUNCT
ecj-12166	102	1	j	j	PROPN
ecj-12166	102	2	clin	clin	PROPN
ecj-12166	102	3	med	me	VERB
ecj-12166	102	4	2023;12	2023;12	NOUN
ecj-12166	102	5	:	:	PUNCT
ecj-12166	102	6	3256	3256	NUM
ecj-12166	102	7	.	.	PUNCT
ecj-12166	103	1	3	3	X
ecj-12166	103	2	.	.	X
ecj-12166	103	3	domino	domino	NOUN
ecj-12166	103	4	ef	ef	PROPN
ecj-12166	103	5	,	,	PUNCT
ecj-12166	103	6	chodoff	chodoff	NOUN
ecj-12166	103	7	p	p	NOUN
ecj-12166	103	8	,	,	PUNCT
ecj-12166	103	9	corssen	corssen	PROPN
ecj-12166	103	10	g.	g.	PROPN
ecj-12166	103	11	pharmacologic	pharmacologic	ADJ
ecj-12166	103	12	effects	effect	NOUN
ecj-12166	103	13	of	of	ADP
ecj-12166	103	14	ci-581	ci-581	PROPN
ecj-12166	103	15	,	,	PUNCT
ecj-12166	103	16	a	a	DET
ecj-12166	103	17	new	new	ADJ
ecj-12166	103	18	dissociative	dissociative	ADJ
ecj-12166	103	19	anesthetic	anesthetic	NOUN
ecj-12166	103	20	,	,	PUNCT
ecj-12166	103	21	in	in	ADP
ecj-12166	103	22	man	man	NOUN
ecj-12166	103	23	.	.	PUNCT
ecj-12166	104	1	clin	clin	PROPN
ecj-12166	104	2	pharmacol	pharmacol	PROPN
ecj-12166	104	3	ther	ther	PROPN
ecj-12166	104	4	1965;6:279	1965;6:279	PROPN
ecj-12166	104	5	-	-	PUNCT
ecj-12166	104	6	91	91	NUM
ecj-12166	104	7	.	.	PUNCT
ecj-12166	105	1	4	4	X
ecj-12166	105	2	.	.	X
ecj-12166	105	3	silverstein	silverstein	PROPN
ecj-12166	105	4	wk	wk	PROPN
ecj-12166	105	5	,	,	PUNCT
ecj-12166	105	6	juurlink	juurlink	PROPN
ecj-12166	105	7	dn	dn	PROPN
ecj-12166	105	8	,	,	PUNCT
ecj-12166	105	9	zipursky	zipursky	PROPN
ecj-12166	105	10	js	js	PROPN
ecj-12166	105	11	.	.	PUNCT
ecj-12166	106	1	ketamine	ketamine	PROPN
ecj-12166	106	2	for	for	ADP
ecj-12166	106	3	the	the	DET
ecj-12166	106	4	treatment	treatment	NOUN
ecj-12166	106	5	of	of	ADP
ecj-12166	106	6	acute	acute	ADJ
ecj-12166	106	7	pain	pain	NOUN
ecj-12166	106	8	.	.	PUNCT
ecj-12166	107	1	cmaj	cmaj	PROPN
ecj-12166	107	2	2021;193	2021;193	NUM
ecj-12166	107	3	:	:	PUNCT
ecj-12166	107	4	e1663	e1663	NUM
ecj-12166	107	5	.	.	PUNCT
ecj-12166	108	1	5	5	NUM
ecj-12166	108	2	.	.	X
ecj-12166	108	3	corriger	corriger	PROPN
ecj-12166	108	4	a	a	PROPN
ecj-12166	108	5	,	,	PUNCT
ecj-12166	108	6	pickering	pickere	VERB
ecj-12166	108	7	g.	g.	PROPN
ecj-12166	108	8	ketamine	ketamine	PROPN
ecj-12166	108	9	and	and	CCONJ
ecj-12166	108	10	depression	depression	NOUN
ecj-12166	108	11	:	:	PUNCT
ecj-12166	108	12	a	a	DET
ecj-12166	108	13	narrative	narrative	NOUN
ecj-12166	108	14	review	review	NOUN
ecj-12166	108	15	.	.	PUNCT
ecj-12166	109	1	drug	drug	NOUN
ecj-12166	109	2	des	des	PROPN
ecj-12166	109	3	devel	devel	NOUN
ecj-12166	109	4	ther	ther	NOUN
ecj-12166	109	5	2019;13:3051	2019;13:3051	NUM
ecj-12166	109	6	-	-	SYM
ecj-12166	109	7	67	67	NUM
ecj-12166	109	8	.	.	NOUN
ecj-12166	109	9	6	6	NUM
ecj-12166	109	10	.	.	X
ecj-12166	109	11	frestadius	frestadius	PROPN
ecj-12166	109	12	a	a	NOUN
ecj-12166	109	13	,	,	PUNCT
ecj-12166	109	14	grehn	grehn	ADJ
ecj-12166	109	15	f	f	PROPN
ecj-12166	109	16	,	,	PUNCT
ecj-12166	109	17	kildal	kildal	PROPN
ecj-12166	109	18	m	m	PROPN
ecj-12166	109	19	,	,	PUNCT
ecj-12166	109	20	et	et	PROPN
ecj-12166	109	21	al	al	PROPN
ecj-12166	109	22	.	.	PROPN
ecj-12166	109	23	intranasal	intranasal	PROPN
ecj-12166	109	24	dexmedetomidine	dexmedetomidine	PROPN
ecj-12166	109	25	and	and	CCONJ
ecj-12166	109	26	rectal	rectal	ADJ
ecj-12166	109	27	ketamine	ketamine	NOUN
ecj-12166	109	28	for	for	ADP
ecj-12166	109	29	young	young	ADJ
ecj-12166	109	30	children	child	NOUN
ecj-12166	109	31	undergoing	undergo	VERB
ecj-12166	109	32	burn	burn	NOUN
ecj-12166	109	33	wound	wound	NOUN
ecj-12166	109	34	procedures	procedure	NOUN
ecj-12166	109	35	.	.	PUNCT
ecj-12166	110	1	burns	burn	VERB
ecj-12166	110	2	2022;48:1445	2022;48:1445	NUM
ecj-12166	110	3	-	-	SYM
ecj-12166	110	4	51	51	NUM
ecj-12166	110	5	.	.	PUNCT
ecj-12166	111	1	7	7	X
ecj-12166	111	2	.	.	X
ecj-12166	111	3	laskowski	laskowski	PROPN
ecj-12166	111	4	k	k	PROPN
ecj-12166	111	5	,	,	PUNCT
ecj-12166	111	6	stirling	stirling	NOUN
ecj-12166	111	7	a	a	PRON
ecj-12166	111	8	,	,	PUNCT
ecj-12166	111	9	mckay	mckay	PROPN
ecj-12166	111	10	wp	wp	PROPN
ecj-12166	111	11	,	,	PUNCT
ecj-12166	111	12	lim	lim	PROPN
ecj-12166	111	13	hj	hj	PROPN
ecj-12166	111	14	.	.	PUNCT
ecj-12166	112	1	a	a	DET
ecj-12166	112	2	systematic	systematic	ADJ
ecj-12166	112	3	review	review	NOUN
ecj-12166	112	4	of	of	ADP
ecj-12166	112	5	intravenous	intravenous	ADJ
ecj-12166	112	6	ketamine	ketamine	PROPN
ecj-12166	112	7	for	for	ADP
ecj-12166	112	8	postoperative	postoperative	ADJ
ecj-12166	112	9	analgesia	analgesia	NOUN
ecj-12166	112	10	.	.	PUNCT
ecj-12166	113	1	can	can	AUX
ecj-12166	113	2	j	j	PROPN
ecj-12166	113	3	anaesth	anaesth	PROPN
ecj-12166	113	4	2011;58:911	2011;58:911	PROPN
ecj-12166	113	5	-	-	SYM
ecj-12166	113	6	23	23	NUM
ecj-12166	113	7	.	.	NOUN
ecj-12166	113	8	8	8	X
ecj-12166	113	9	.	.	X
ecj-12166	113	10	fang	fang	PROPN
ecj-12166	113	11	y	y	PROPN
ecj-12166	113	12	,	,	PUNCT
ecj-12166	113	13	wang	wang	PROPN
ecj-12166	113	14	x.	x.	PROPN
ecj-12166	113	15	ketamine	ketamine	PROPN
ecj-12166	113	16	for	for	ADP
ecj-12166	113	17	the	the	DET
ecj-12166	113	18	treatment	treatment	NOUN
ecj-12166	113	19	of	of	ADP
ecj-12166	113	20	refractory	refractory	NOUN
ecj-12166	113	21	status	status	NOUN
ecj-12166	113	22	epilepticus	epilepticus	VERB
ecj-12166	113	23	.	.	PUNCT
ecj-12166	114	1	seizure	seizure	VERB
ecj-12166	114	2	2015;30:14	2015;30:14	NUM
ecj-12166	114	3	-	-	SYM
ecj-12166	114	4	20	20	NUM
ecj-12166	114	5	.	.	NOUN
ecj-12166	115	1	9	9	NUM
ecj-12166	115	2	.	.	X
ecj-12166	116	1	petrakis	petrakis	PROPN
ecj-12166	116	2	il	il	PROPN
ecj-12166	116	3	,	,	PUNCT
ecj-12166	116	4	limoncelli	limoncelli	PROPN
ecj-12166	116	5	d	d	PROPN
ecj-12166	116	6	,	,	PUNCT
ecj-12166	116	7	gueorguieva	gueorguieva	ADJ
ecj-12166	116	8	r	r	NOUN
ecj-12166	116	9	,	,	PUNCT
ecj-12166	116	10	et	et	PROPN
ecj-12166	116	11	al	al	PROPN
ecj-12166	116	12	.	.	PROPN
ecj-12166	116	13	altered	alter	VERB
ecj-12166	116	14	nmda	nmda	ADJ
ecj-12166	116	15	glutamate	glutamate	ADJ
ecj-12166	116	16	receptor	receptor	NOUN
ecj-12166	116	17	antagonist	antagonist	NOUN
ecj-12166	116	18	response	response	NOUN
ecj-12166	116	19	in	in	ADP
ecj-12166	116	20	individuals	individual	NOUN
ecj-12166	116	21	with	with	ADP
ecj-12166	116	22	a	a	DET
ecj-12166	116	23	family	family	NOUN
ecj-12166	116	24	vulnerability	vulnerability	NOUN
ecj-12166	116	25	to	to	ADP
ecj-12166	116	26	alcoholism	alcoholism	NOUN
ecj-12166	116	27	.	.	PUNCT
ecj-12166	117	1	am	be	AUX
ecj-12166	117	2	j	j	PROPN
ecj-12166	117	3	psychiatry	psychiatry	PROPN
ecj-12166	117	4	2004;161:1776	2004;161:1776	PROPN
ecj-12166	117	5	-	-	SYM
ecj-12166	117	6	82	82	NUM
ecj-12166	117	7	.	.	PUNCT
ecj-12166	117	8	10	10	NUM
ecj-12166	117	9	.	.	PUNCT
ecj-12166	118	1	jones	jones	PROPN
ecj-12166	118	2	jl	jl	PROPN
ecj-12166	118	3	,	,	PUNCT
ecj-12166	118	4	mateus	mateus	PROPN
ecj-12166	118	5	cf	cf	PROPN
ecj-12166	118	6	,	,	PUNCT
ecj-12166	118	7	malcolm	malcolm	PROPN
ecj-12166	118	8	rj	rj	PROPN
ecj-12166	118	9	,	,	PUNCT
ecj-12166	118	10	et	et	PROPN
ecj-12166	118	11	al	al	PROPN
ecj-12166	118	12	.	.	PROPN
ecj-12166	118	13	efficacy	efficacy	PROPN
ecj-12166	118	14	of	of	ADP
ecj-12166	118	15	ketamine	ketamine	PROPN
ecj-12166	118	16	in	in	ADP
ecj-12166	118	17	the	the	DET
ecj-12166	118	18	treatment	treatment	NOUN
ecj-12166	118	19	of	of	ADP
ecj-12166	118	20	substance	substance	NOUN
ecj-12166	118	21	use	use	NOUN
ecj-12166	118	22	disorders	disorder	NOUN
ecj-12166	118	23	:	:	PUNCT
ecj-12166	118	24	a	a	DET
ecj-12166	118	25	systematic	systematic	ADJ
ecj-12166	118	26	review	review	NOUN
ecj-12166	118	27	.	.	PUNCT
ecj-12166	119	1	front	front	ADJ
ecj-12166	119	2	psychiatry	psychiatry	NOUN
ecj-12166	119	3	2018;9:277	2018;9:277	NOUN
ecj-12166	119	4	.	.	PUNCT
ecj-12166	120	1	11	11	NUM
ecj-12166	120	2	.	.	X
ecj-12166	121	1	springer	springer	PROPN
ecj-12166	121	2	b.	b.	PROPN
ecj-12166	121	3	hyperactive	hyperactive	PROPN
ecj-12166	121	4	delirium	delirium	NOUN
ecj-12166	121	5	with	with	ADP
ecj-12166	121	6	severe	severe	ADJ
ecj-12166	121	7	agitation	agitation	NOUN
ecj-12166	121	8	.	.	PUNCT
ecj-12166	122	1	emerg	emerg	PROPN
ecj-12166	122	2	med	med	PROPN
ecj-12166	122	3	clin	clin	PROPN
ecj-12166	122	4	north	north	PROPN
ecj-12166	122	5	am	be	AUX
ecj-12166	122	6	2024;42:41	2024;42:41	NUM
ecj-12166	122	7	-	-	SYM
ecj-12166	122	8	52	52	NUM
ecj-12166	122	9	.	.	PUNCT
ecj-12166	123	1	12	12	NUM
ecj-12166	123	2	.	.	PUNCT
ecj-12166	124	1	morgan	morgan	PROPN
ecj-12166	124	2	mm	mm	PROPN
ecj-12166	124	3	,	,	PUNCT
ecj-12166	124	4	perina	perina	PROPN
ecj-12166	124	5	dg	dg	PROPN
ecj-12166	124	6	,	,	PUNCT
ecj-12166	124	7	acquisto	acquisto	PROPN
ecj-12166	124	8	nm	nm	PROPN
ecj-12166	124	9	,	,	PUNCT
ecj-12166	124	10	et	et	PROPN
ecj-12166	124	11	al	al	PROPN
ecj-12166	124	12	.	.	PROPN
ecj-12166	125	1	ketamine	ketamine	PROPN
ecj-12166	125	2	use	use	NOUN
ecj-12166	125	3	in	in	ADP
ecj-12166	125	4	prehospital	prehospital	NOUN
ecj-12166	125	5	and	and	CCONJ
ecj-12166	125	6	hospital	hospital	NOUN
ecj-12166	125	7	treatment	treatment	NOUN
ecj-12166	125	8	of	of	ADP
ecj-12166	125	9	the	the	DET
ecj-12166	125	10	acute	acute	ADJ
ecj-12166	125	11	trauma	trauma	NOUN
ecj-12166	125	12	patient	patient	NOUN
ecj-12166	125	13	:	:	PUNCT
ecj-12166	125	14	a	a	DET
ecj-12166	125	15	joint	joint	ADJ
ecj-12166	125	16	position	position	NOUN
ecj-12166	125	17	statement	statement	NOUN
ecj-12166	125	18	.	.	PUNCT
ecj-12166	126	1	prehosp	prehosp	PROPN
ecj-12166	126	2	emerg	emerg	PROPN
ecj-12166	126	3	care	care	NOUN
ecj-12166	126	4	2021;25:588	2021;25:588	PROPN
ecj-12166	126	5	-	-	SYM
ecj-12166	126	6	92	92	NUM
ecj-12166	126	7	.	.	PUNCT
ecj-12166	126	8	13	13	NUM
ecj-12166	126	9	.	.	PUNCT
ecj-12166	127	1	verma	verma	PROPN
ecj-12166	127	2	a	a	PROPN
ecj-12166	127	3	,	,	PUNCT
ecj-12166	127	4	snehy	snehy	PROPN
ecj-12166	127	5	a	a	PRON
ecj-12166	127	6	,	,	PUNCT
ecj-12166	127	7	vishen	vishen	ADV
ecj-12166	127	8	a	a	X
ecj-12166	127	9	,	,	PUNCT
ecj-12166	127	10	et	et	PROPN
ecj-12166	127	11	al	al	PROPN
ecj-12166	127	12	.	.	PROPN
ecj-12166	128	1	ketamine	ketamine	PROPN
ecj-12166	128	2	use	use	NOUN
ecj-12166	128	3	allows	allow	VERB
ecj-12166	128	4	noninvasive	noninvasive	ADJ
ecj-12166	128	5	ventilation	ventilation	NOUN
ecj-12166	128	6	in	in	ADP
ecj-12166	128	7	distressed	distressed	ADJ
ecj-12166	128	8	patients	patient	NOUN
ecj-12166	128	9	with	with	ADP
ecj-12166	128	10	acute	acute	ADJ
ecj-12166	128	11	decompensated	decompensate	VERB
ecj-12166	128	12	heart	heart	NOUN
ecj-12166	128	13	failure	failure	NOUN
ecj-12166	128	14	.	.	PUNCT
ecj-12166	129	1	indian	indian	PROPN
ecj-12166	129	2	j	j	PROPN
ecj-12166	129	3	crit	crit	PROPN
ecj-12166	129	4	care	care	NOUN
ecj-12166	129	5	med	me	VERB
ecj-12166	129	6	2019;23:191	2019;23:191	PROPN
ecj-12166	129	7	-	-	SYM
ecj-12166	129	8	2	2	NUM
ecj-12166	129	9	.	.	NOUN
ecj-12166	129	10	14	14	NUM
ecj-12166	129	11	.	.	PUNCT
ecj-12166	130	1	kiureghian	kiureghian	PROPN
ecj-12166	130	2	e	e	PROPN
ecj-12166	130	3	,	,	PUNCT
ecj-12166	130	4	kowalski	kowalski	PROPN
ecj-12166	130	5	jm	jm	PROPN
ecj-12166	130	6	.	.	PROPN
ecj-12166	130	7	intravenous	intravenous	PROPN
ecj-12166	130	8	ketamine	ketamine	PROPN
ecj-12166	130	9	to	to	PART
ecj-12166	130	10	facilitate	facilitate	VERB
ecj-12166	130	11	noninvasive	noninvasive	ADJ
ecj-12166	130	12	ventilation	ventilation	NOUN
ecj-12166	130	13	in	in	ADP
ecj-12166	130	14	a	a	DET
ecj-12166	130	15	patient	patient	NOUN
ecj-12166	130	16	with	with	ADP
ecj-12166	130	17	a	a	DET
ecj-12166	130	18	severe	severe	ADJ
ecj-12166	130	19	asthma	asthma	NOUN
ecj-12166	130	20	exacerbation	exacerbation	NOUN
ecj-12166	130	21	.	.	PUNCT
ecj-12166	131	1	am	be	AUX
ecj-12166	131	2	j	j	PROPN
ecj-12166	131	3	emerg	emerg	PROPN
ecj-12166	131	4	med	med	PROPN
ecj-12166	131	5	2015;33:1720.e1	2015;33:1720.e1	PROPN
ecj-12166	131	6	-	-	PUNCT
ecj-12166	131	7	2	2	NUM
ecj-12166	131	8	.	.	NOUN
ecj-12166	131	9	15	15	NUM
ecj-12166	131	10	.	.	X
ecj-12166	132	1	riccardi	riccardi	VERB
ecj-12166	132	2	a	a	PRON
ecj-12166	132	3	,	,	PUNCT
ecj-12166	132	4	serra	serra	PROPN
ecj-12166	132	5	s	s	PROPN
ecj-12166	132	6	,	,	PUNCT
ecj-12166	132	7	de	de	X
ecj-12166	132	8	iaco	iaco	PROPN
ecj-12166	132	9	f	f	PROPN
ecj-12166	132	10	,	,	PUNCT
ecj-12166	132	11	et	et	PROPN
ecj-12166	132	12	al	al	PROPN
ecj-12166	132	13	.	.	PUNCT
ecj-12166	133	1	uncovering	uncover	VERB
ecj-12166	133	2	the	the	DET
ecj-12166	133	3	benefits	benefit	NOUN
ecj-12166	133	4	of	of	ADP
ecj-12166	133	5	the	the	DET
ecj-12166	133	6	ketamine	ketamine	PROPN
ecj-12166	133	7	-	-	PUNCT
ecj-12166	133	8	dexmedetomidine	dexmedetomidine	NOUN
ecj-12166	133	9	combination	combination	NOUN
ecj-12166	133	10	for	for	ADP
ecj-12166	133	11	procedural	procedural	ADJ
ecj-12166	133	12	sedation	sedation	NOUN
ecj-12166	133	13	during	during	ADP
ecj-12166	133	14	the	the	DET
ecj-12166	133	15	italian	italian	ADJ
ecj-12166	133	16	covid-19	covid-19	PROPN
ecj-12166	133	17	pandemic	pandemic	NOUN
ecj-12166	133	18	.	.	PUNCT
ecj-12166	134	1	j	j	PROPN
ecj-12166	134	2	clin	clin	PROPN
ecj-12166	134	3	med	med	PROPN
ecj-12166	134	4	2023;12:3124	2023;12:3124	PROPN
ecj-12166	134	5	.	.	PROPN
ecj-12166	135	1	16	16	NUM
ecj-12166	135	2	.	.	PUNCT
ecj-12166	136	1	karim	karim	PROPN
ecj-12166	136	2	hm	hm	INTJ
ecj-12166	136	3	,	,	PUNCT
ecj-12166	136	4	šarc	šarc	PROPN
ecj-12166	136	5	i	i	PROPN
ecj-12166	136	6	,	,	PUNCT
ecj-12166	136	7	calandra	calandra	PROPN
ecj-12166	136	8	c	c	PROPN
ecj-12166	136	9	,	,	PUNCT
ecj-12166	136	10	et	et	PROPN
ecj-12166	136	11	al	al	PROPN
ecj-12166	136	12	.	.	PUNCT
ecj-12166	137	1	role	role	NOUN
ecj-12166	137	2	of	of	ADP
ecj-12166	137	3	sedation	sedation	NOUN
ecj-12166	137	4	and	and	CCONJ
ecj-12166	137	5	analgesia	analgesia	NOUN
ecj-12166	137	6	during	during	ADP
ecj-12166	137	7	noninvasive	noninvasive	ADJ
ecj-12166	137	8	ventilation	ventilation	NOUN
ecj-12166	137	9	:	:	PUNCT
ecj-12166	137	10	systematic	systematic	ADJ
ecj-12166	137	11	review	review	NOUN
ecj-12166	137	12	of	of	ADP
ecj-12166	137	13	recent	recent	ADJ
ecj-12166	137	14	evidence	evidence	NOUN
ecj-12166	137	15	and	and	CCONJ
ecj-12166	137	16	recommendations	recommendation	NOUN
ecj-12166	137	17	.	.	PUNCT
ecj-12166	138	1	indian	indian	PROPN
ecj-12166	138	2	j	j	PROPN
ecj-12166	138	3	crit	crit	PROPN
ecj-12166	138	4	care	care	PROPN
ecj-12166	138	5	med	med	PROPN
ecj-12166	138	6	2022;26:938	2022;26:938	PROPN
ecj-12166	138	7	-	-	SYM
ecj-12166	138	8	48	48	NUM
ecj-12166	138	9	.	.	PUNCT
ecj-12166	139	1	17	17	NUM
ecj-12166	139	2	.	.	PUNCT
ecj-12166	140	1	zanos	zanos	PROPN
ecj-12166	140	2	p	p	PROPN
ecj-12166	140	3	,	,	PUNCT
ecj-12166	140	4	moaddel	moaddel	NOUN
ecj-12166	140	5	r	r	PROPN
ecj-12166	140	6	,	,	PUNCT
ecj-12166	140	7	morris	morris	PROPN
ecj-12166	140	8	pj	pj	PROPN
ecj-12166	140	9	,	,	PUNCT
ecj-12166	140	10	et	et	PROPN
ecj-12166	140	11	al	al	PROPN
ecj-12166	140	12	.	.	PROPN
ecj-12166	141	1	ketamine	ketamine	PROPN
ecj-12166	141	2	and	and	CCONJ
ecj-12166	141	3	ketamine	ketamine	PROPN
ecj-12166	141	4	metabolite	metabolite	PROPN
ecj-12166	141	5	pharmacology	pharmacology	NOUN
ecj-12166	141	6	:	:	PUNCT
ecj-12166	141	7	insights	insight	NOUN
ecj-12166	141	8	into	into	ADP
ecj-12166	141	9	therapeutic	therapeutic	ADJ
ecj-12166	141	10	mechanisms	mechanism	NOUN
ecj-12166	141	11	.	.	PUNCT
ecj-12166	142	1	pharmacol	pharmacol	PROPN
ecj-12166	142	2	rev	rev	VERB
ecj-12166	142	3	2018;70:621	2018;70:621	NUM
ecj-12166	142	4	-	-	SYM
ecj-12166	142	5	60	60	NUM
ecj-12166	142	6	.	.	PUNCT
ecj-12166	143	1	18	18	NUM
ecj-12166	143	2	.	.	PUNCT
ecj-12166	144	1	desta	desta	PROPN
ecj-12166	144	2	z	z	PROPN
ecj-12166	144	3	,	,	PUNCT
ecj-12166	144	4	moaddel	moaddel	PROPN
ecj-12166	144	5	r	r	NOUN
ecj-12166	144	6	,	,	PUNCT
ecj-12166	144	7	ogburn	ogburn	NOUN
ecj-12166	144	8	et	et	PROPN
ecj-12166	144	9	,	,	PUNCT
ecj-12166	144	10	et	et	PROPN
ecj-12166	144	11	al	al	PROPN
ecj-12166	144	12	.	.	PROPN
ecj-12166	144	13	stereoselective	stereoselective	PROPN
ecj-12166	144	14	and	and	CCONJ
ecj-12166	144	15	regiospecific	regiospecific	NOUN
ecj-12166	144	16	hydroxylation	hydroxylation	NOUN
ecj-12166	144	17	of	of	ADP
ecj-12166	144	18	ketamine	ketamine	PROPN
ecj-12166	144	19	and	and	CCONJ
ecj-12166	144	20	norketamine	norketamine	PROPN
ecj-12166	144	21	.	.	PUNCT
ecj-12166	145	1	xenobiotica	xenobiotica	PROPN
ecj-12166	146	1	2012;42:1076	2012;42:1076	PROPN
ecj-12166	146	2	-	-	SYM
ecj-12166	146	3	87	87	NUM
ecj-12166	146	4	.	.	PUNCT
ecj-12166	147	1	19	19	NUM
ecj-12166	147	2	.	.	PUNCT
ecj-12166	147	3	hijazi	hijazi	PROPN
ecj-12166	147	4	y	y	PROPN
ecj-12166	147	5	,	,	PUNCT
ecj-12166	147	6	boulieu	boulieu	PROPN
ecj-12166	147	7	r.	r.	PROPN
ecj-12166	147	8	contribution	contribution	NOUN
ecj-12166	147	9	of	of	ADP
ecj-12166	147	10	cyp3a4	cyp3a4	PROPN
ecj-12166	147	11	,	,	PUNCT
ecj-12166	147	12	cyp2b6	cyp2b6	NOUN
ecj-12166	147	13	,	,	PUNCT
ecj-12166	147	14	and	and	CCONJ
ecj-12166	147	15	cyp2c9	cyp2c9	NOUN
ecj-12166	147	16	isoforms	isoform	NOUN
ecj-12166	147	17	to	to	ADP
ecj-12166	147	18	n	n	CCONJ
ecj-12166	147	19	-	-	PUNCT
ecj-12166	147	20	demethylation	demethylation	NOUN
ecj-12166	147	21	of	of	ADP
ecj-12166	147	22	ketamine	ketamine	PROPN
ecj-12166	147	23	in	in	ADP
ecj-12166	147	24	human	human	ADJ
ecj-12166	147	25	liver	liver	NOUN
ecj-12166	147	26	microsomes	microsome	NOUN
ecj-12166	147	27	.	.	PUNCT
ecj-12166	148	1	drug	drug	NOUN
ecj-12166	148	2	metab	metab	PROPN
ecj-12166	148	3	dispos	dispos	PROPN
ecj-12166	148	4	2002;30:853	2002;30:853	NUM
ecj-12166	148	5	-	-	SYM
ecj-12166	148	6	8	8	NUM
ecj-12166	148	7	.	.	NOUN
ecj-12166	148	8	20	20	NUM
ecj-12166	148	9	.	.	PUNCT
ecj-12166	149	1	peltoniemi	peltoniemi	PROPN
ecj-12166	149	2	ma	ma	PROPN
ecj-12166	149	3	,	,	PUNCT
ecj-12166	149	4	hagelberg	hagelberg	PROPN
ecj-12166	149	5	nm	nm	PROPN
ecj-12166	149	6	,	,	PUNCT
ecj-12166	149	7	olkkola	olkkola	PROPN
ecj-12166	149	8	kt	kt	PROPN
ecj-12166	149	9	,	,	PUNCT
ecj-12166	149	10	saari	saari	PROPN
ecj-12166	149	11	ti	ti	PROPN
ecj-12166	149	12	.	.	PROPN
ecj-12166	149	13	ketamine	ketamine	PROPN
ecj-12166	149	14	:	:	PUNCT
ecj-12166	149	15	a	a	DET
ecj-12166	149	16	review	review	NOUN
ecj-12166	149	17	of	of	ADP
ecj-12166	149	18	clinical	clinical	ADJ
ecj-12166	149	19	pharmacokinetics	pharmacokinetic	NOUN
ecj-12166	149	20	and	and	CCONJ
ecj-12166	149	21	pharmacodynamics	pharmacodynamic	NOUN
ecj-12166	149	22	in	in	ADP
ecj-12166	149	23	anesthesia	anesthesia	NOUN
ecj-12166	149	24	and	and	CCONJ
ecj-12166	149	25	pain	pain	NOUN
ecj-12166	149	26	therapy	therapy	NOUN
ecj-12166	149	27	.	.	PUNCT
ecj-12166	150	1	clin	clin	PROPN
ecj-12166	150	2	pharmacokinet	pharmacokinet	PROPN
ecj-12166	150	3	2016;55:1059	2016;55:1059	PROPN
ecj-12166	150	4	-	-	SYM
ecj-12166	150	5	77	77	NUM
ecj-12166	150	6	.	.	PUNCT
ecj-12166	150	7	21	21	NUM
ecj-12166	150	8	.	.	PUNCT
ecj-12166	151	1	sinner	sinner	PROPN
ecj-12166	151	2	b	b	PROPN
ecj-12166	151	3	,	,	PUNCT
ecj-12166	151	4	graf	graf	PROPN
ecj-12166	151	5	bm	bm	PROPN
ecj-12166	151	6	.	.	PROPN
ecj-12166	151	7	ketamine	ketamine	PROPN
ecj-12166	151	8	.	.	PUNCT
ecj-12166	152	1	handb	handb	PROPN
ecj-12166	152	2	exp	exp	NOUN
ecj-12166	152	3	pharmacol	pharmacol	PROPN
ecj-12166	152	4	2008	2008	NUM
ecj-12166	152	5	,	,	PUNCT
ecj-12166	152	6	p.	p.	NOUN
ecj-12166	152	7	313	313	NUM
ecj-12166	152	8	-	-	SYM
ecj-12166	152	9	333	333	NUM
ecj-12166	152	10	.	.	PUNCT
ecj-12166	153	1	22	22	NUM
ecj-12166	153	2	.	.	PUNCT
ecj-12166	154	1	dayton	dayton	PROPN
ecj-12166	154	2	pg	pg	PROPN
ecj-12166	154	3	,	,	PUNCT
ecj-12166	154	4	stiller	stiller	PROPN
ecj-12166	154	5	rl	rl	PROPN
ecj-12166	154	6	,	,	PUNCT
ecj-12166	154	7	cook	cook	PROPN
ecj-12166	154	8	dr	dr	PROPN
ecj-12166	154	9	,	,	PUNCT
ecj-12166	154	10	perel	perel	PROPN
ecj-12166	154	11	jm	jm	PROPN
ecj-12166	154	12	.	.	PUNCT
ecj-12166	155	1	the	the	DET
ecj-12166	155	2	binding	binding	NOUN
ecj-12166	155	3	of	of	ADP
ecj-12166	155	4	ketamine	ketamine	PROPN
ecj-12166	155	5	to	to	ADP
ecj-12166	155	6	plasma	plasma	NOUN
ecj-12166	155	7	proteins	protein	NOUN
ecj-12166	155	8	:	:	PUNCT
ecj-12166	155	9	emphasis	emphasis	NOUN
ecj-12166	155	10	on	on	ADP
ecj-12166	155	11	human	human	ADJ
ecj-12166	155	12	plasma	plasma	NOUN
ecj-12166	155	13	.	.	PUNCT
ecj-12166	156	1	eur	eur	PROPN
ecj-12166	156	2	j	j	PROPN
ecj-12166	156	3	clin	clin	PROPN
ecj-12166	156	4	pharmacol	pharmacol	PROPN
ecj-12166	156	5	1983;24:825	1983;24:825	PROPN
ecj-12166	156	6	-	-	PUNCT
ecj-12166	156	7	31	31	NUM
ecj-12166	156	8	.	.	PUNCT
ecj-12166	156	9	23	23	NUM
ecj-12166	156	10	.	.	PUNCT
ecj-12166	157	1	gottlieb	gottlieb	PROPN
ecj-12166	157	2	m	m	PROPN
ecj-12166	157	3	,	,	PUNCT
ecj-12166	157	4	long	long	ADJ
ecj-12166	157	5	b	b	NOUN
ecj-12166	157	6	,	,	PUNCT
ecj-12166	157	7	koyfman	koyfman	ADJ
ecj-12166	157	8	a.	a.	NOUN
ecj-12166	157	9	approach	approach	NOUN
ecj-12166	157	10	to	to	ADP
ecj-12166	157	11	the	the	DET
ecj-12166	157	12	agitated	agitated	ADJ
ecj-12166	157	13	emergency	emergency	NOUN
ecj-12166	157	14	department	department	NOUN
ecj-12166	157	15	patient	patient	NOUN
ecj-12166	157	16	.	.	PUNCT
ecj-12166	158	1	j	j	PROPN
ecj-12166	158	2	emerg	emerg	PROPN
ecj-12166	158	3	med	med	PROPN
ecj-12166	158	4	2018;54:44757	2018;54:44757	NUM
ecj-12166	158	5	.	.	PROPN
ecj-12166	158	6	24	24	NUM
ecj-12166	158	7	.	.	PUNCT
ecj-12166	159	1	poonai	poonai	PROPN
ecj-12166	159	2	n	n	PROPN
ecj-12166	159	3	,	,	PUNCT
ecj-12166	159	4	canton	canton	PROPN
ecj-12166	159	5	k	k	PROPN
ecj-12166	159	6	,	,	PUNCT
ecj-12166	159	7	ali	ali	PROPN
ecj-12166	159	8	s	s	PROPN
ecj-12166	159	9	,	,	PUNCT
ecj-12166	159	10	et	et	PROPN
ecj-12166	159	11	al	al	PROPN
ecj-12166	159	12	.	.	PROPN
ecj-12166	159	13	intranasal	intranasal	PROPN
ecj-12166	159	14	ketamine	ketamine	PROPN
ecj-12166	159	15	for	for	ADP
ecj-12166	159	16	procedural	procedural	ADJ
ecj-12166	159	17	sedation	sedation	NOUN
ecj-12166	159	18	and	and	CCONJ
ecj-12166	159	19	analgesia	analgesia	NOUN
ecj-12166	159	20	in	in	ADP
ecj-12166	159	21	children	child	NOUN
ecj-12166	159	22	:	:	PUNCT
ecj-12166	159	23	a	a	DET
ecj-12166	159	24	systematic	systematic	ADJ
ecj-12166	159	25	review	review	NOUN
ecj-12166	159	26	.	.	PUNCT
ecj-12166	160	1	plos	plos	PROPN
ecj-12166	160	2	one	one	NUM
ecj-12166	160	3	2017;12	2017;12	NOUN
ecj-12166	160	4	:	:	PUNCT
ecj-12166	160	5	e0173253	e0173253	ADJ
ecj-12166	160	6	.	.	PROPN
ecj-12166	161	1	25	25	NUM
ecj-12166	161	2	.	.	PUNCT
ecj-12166	162	1	choi	choi	PROPN
ecj-12166	162	2	e	e	PROPN
ecj-12166	162	3	-	-	PROPN
ecj-12166	162	4	j	j	PROPN
ecj-12166	162	5	,	,	PUNCT
ecj-12166	162	6	kim	kim	PROPN
ecj-12166	162	7	c	c	PROPN
ecj-12166	162	8	-	-	PUNCT
ecj-12166	162	9	h	h	PROPN
ecj-12166	162	10	,	,	PUNCT
ecj-12166	162	11	yoon	yoon	PROPN
ecj-12166	162	12	j	j	PROPN
ecj-12166	162	13	-	-	PROPN
ecj-12166	162	14	y	y	PROPN
ecj-12166	162	15	,	,	PUNCT
ecj-12166	162	16	kim	kim	PROPN
ecj-12166	162	17	e	e	PROPN
ecj-12166	162	18	-	-	PROPN
ecj-12166	162	19	j.	j.	PROPN
ecj-12166	162	20	ketamine	ketamine	PROPN
ecj-12166	162	21	-	-	PUNCT
ecj-12166	162	22	propofol	propofol	NOUN
ecj-12166	162	23	(	(	PUNCT
ecj-12166	162	24	ketofol	ketofol	ADJ
ecj-12166	162	25	)	)	PUNCT
ecj-12166	162	26	in	in	ADP
ecj-12166	162	27	procedural	procedural	ADJ
ecj-12166	162	28	sedation	sedation	NOUN
ecj-12166	162	29	:	:	PUNCT
ecj-12166	162	30	a	a	DET
ecj-12166	162	31	narrative	narrative	NOUN
ecj-12166	162	32	review	review	NOUN
ecj-12166	162	33	.	.	PUNCT
ecj-12166	163	1	j	j	PROPN
ecj-12166	163	2	dent	dent	PROPN
ecj-12166	163	3	anesth	anesth	VERB
ecj-12166	163	4	pain	pain	NOUN
ecj-12166	163	5	med	me	VERB
ecj-12166	163	6	2023;23:123	2023;23:123	PROPN
ecj-12166	163	7	-	-	SYM
ecj-12166	163	8	33	33	NUM
ecj-12166	163	9	.	.	NOUN
ecj-12166	164	1	26	26	NUM
ecj-12166	164	2	.	.	PUNCT
ecj-12166	165	1	noppers	nopper	NOUN
ecj-12166	165	2	i	i	PROPN
ecj-12166	165	3	,	,	PUNCT
ecj-12166	165	4	niesters	niesters	PROPN
ecj-12166	165	5	m	m	PROPN
ecj-12166	165	6	,	,	PUNCT
ecj-12166	165	7	aarts	aarts	PROPN
ecj-12166	165	8	l	l	NOUN
ecj-12166	165	9	,	,	PUNCT
ecj-12166	165	10	et	et	PROPN
ecj-12166	165	11	al	al	PROPN
ecj-12166	165	12	.	.	PROPN
ecj-12166	165	13	ketamine	ketamine	PROPN
ecj-12166	165	14	for	for	ADP
ecj-12166	165	15	the	the	DET
ecj-12166	165	16	treatment	treatment	NOUN
ecj-12166	165	17	of	of	ADP
ecj-12166	165	18	chronic	chronic	ADJ
ecj-12166	165	19	non	non	ADJ
ecj-12166	165	20	-	-	ADJ
ecj-12166	165	21	cancer	cancer	ADJ
ecj-12166	165	22	pain	pain	NOUN
ecj-12166	165	23	.	.	PUNCT
ecj-12166	166	1	expert	expert	NOUN
ecj-12166	166	2	opin	opin	NOUN
ecj-12166	166	3	pharmacother	pharmacother	NOUN
ecj-12166	166	4	2010;11:2417	2010;11:2417	NUM
ecj-12166	166	5	-	-	SYM
ecj-12166	166	6	29	29	NUM
ecj-12166	166	7	.	.	PUNCT
ecj-12166	166	8	27	27	NUM
ecj-12166	166	9	.	.	PUNCT
ecj-12166	167	1	fabbri	fabbri	NOUN
ecj-12166	167	2	a	a	PRON
ecj-12166	167	3	,	,	PUNCT
ecj-12166	167	4	voza	voza	NOUN
ecj-12166	167	5	a	a	PRON
ecj-12166	167	6	,	,	PUNCT
ecj-12166	167	7	riccardi	riccardi	VERB
ecj-12166	167	8	a	a	X
ecj-12166	167	9	,	,	PUNCT
ecj-12166	167	10	et	et	PROPN
ecj-12166	167	11	al	al	PROPN
ecj-12166	167	12	.	.	PUNCT
ecj-12166	168	1	the	the	DET
ecj-12166	168	2	pain	pain	NOUN
ecj-12166	168	3	management	management	NOUN
ecj-12166	168	4	of	of	ADP
ecj-12166	168	5	trauma	trauma	NOUN
ecj-12166	168	6	patients	patient	NOUN
ecj-12166	168	7	in	in	ADP
ecj-12166	168	8	the	the	DET
ecj-12166	168	9	emergency	emergency	NOUN
ecj-12166	168	10	department	department	NOUN
ecj-12166	168	11	.	.	PUNCT
ecj-12166	169	1	j	j	PROPN
ecj-12166	169	2	clin	clin	PROPN
ecj-12166	169	3	med	med	PROPN
ecj-12166	169	4	2023;12:3289	2023;12:3289	PROPN
ecj-12166	169	5	.	.	PUNCT
ecj-12166	170	1	28	28	NUM
ecj-12166	170	2	.	.	PUNCT
ecj-12166	171	1	weber	weber	PROPN
ecj-12166	171	2	f	f	PROPN
ecj-12166	171	3	,	,	PUNCT
ecj-12166	171	4	wulf	wulf	PROPN
ecj-12166	171	5	h	h	PROPN
ecj-12166	171	6	,	,	PUNCT
ecj-12166	171	7	gruber	gruber	PROPN
ecj-12166	171	8	m	m	PROPN
ecj-12166	171	9	,	,	PUNCT
ecj-12166	171	10	biallas	biallas	PROPN
ecj-12166	171	11	r.	r.	PROPN
ecj-12166	171	12	s	s	PROPN
ecj-12166	171	13	-	-	PUNCT
ecj-12166	171	14	ketamine	ketamine	PROPN
ecj-12166	171	15	and	and	CCONJ
ecj-12166	171	16	s	s	NOUN
ecj-12166	171	17	-	-	ADJ
ecj-12166	171	18	norketamine	norketamine	ADJ
ecj-12166	171	19	plasma	plasma	NOUN
ecj-12166	171	20	concentrations	concentration	NOUN
ecj-12166	171	21	after	after	ADP
ecj-12166	171	22	nasal	nasal	NOUN
ecj-12166	171	23	and	and	CCONJ
ecj-12166	171	24	i.v	i.v	PROPN
ecj-12166	171	25	.	.	PROPN
ecj-12166	171	26	administration	administration	PROPN
ecj-12166	171	27	in	in	ADP
ecj-12166	171	28	anesthetized	anesthetized	ADJ
ecj-12166	171	29	children	child	NOUN
ecj-12166	171	30	.	.	PUNCT
ecj-12166	172	1	paediatr	paediatr	NOUN
ecj-12166	172	2	anaesth	anaesth	PROPN
ecj-12166	172	3	2004;14:983	2004;14:983	PROPN
ecj-12166	172	4	-	-	PUNCT
ecj-12166	172	5	8	8	NUM
ecj-12166	172	6	.	.	NOUN
ecj-12166	172	7	29	29	NUM
ecj-12166	172	8	.	.	PUNCT
ecj-12166	173	1	buonsenso	buonsenso	PROPN
ecj-12166	173	2	d	d	PROPN
ecj-12166	173	3	,	,	PUNCT
ecj-12166	173	4	barone	barone	PROPN
ecj-12166	173	5	g	g	PROPN
ecj-12166	173	6	,	,	PUNCT
ecj-12166	173	7	valentini	valentini	PROPN
ecj-12166	173	8	p	p	NOUN
ecj-12166	173	9	,	,	PUNCT
ecj-12166	173	10	et	et	PROPN
ecj-12166	173	11	al	al	PROPN
ecj-12166	173	12	.	.	PUNCT
ecj-12166	173	13	utility	utility	NOUN
ecj-12166	173	14	of	of	ADP
ecj-12166	173	15	intranasal	intranasal	NOUN
ecj-12166	173	16	ketamine	ketamine	PROPN
ecj-12166	173	17	and	and	CCONJ
ecj-12166	173	18	midazolam	midazolam	PRON
ecj-12166	173	19	to	to	PART
ecj-12166	173	20	perform	perform	VERB
ecj-12166	173	21	gastric	gastric	ADJ
ecj-12166	173	22	aspirates	aspirate	NOUN
ecj-12166	173	23	in	in	ADP
ecj-12166	173	24	children	child	NOUN
ecj-12166	173	25	:	:	PUNCT
ecj-12166	173	26	a	a	PRON
ecj-12166	173	27	double	double	ADJ
ecj-12166	173	28	-	-	PUNCT
ecj-12166	173	29	blind	blind	ADJ
ecj-12166	173	30	,	,	PUNCT
ecj-12166	173	31	placebo	placebo	NOUN
ecj-12166	173	32	controlled	control	VERB
ecj-12166	173	33	,	,	PUNCT
ecj-12166	173	34	randomized	randomized	ADJ
ecj-12166	173	35	study	study	NOUN
ecj-12166	173	36	.	.	PUNCT
ecj-12166	174	1	bmc	bmc	ADJ
ecj-12166	174	2	pediatr	pediatr	ADJ
ecj-12166	174	3	2014;14:67	2014;14:67	NUM
ecj-12166	174	4	.	.	PUNCT
ecj-12166	175	1	30	30	NUM
ecj-12166	175	2	.	.	PUNCT
ecj-12166	176	1	huge	huge	ADJ
ecj-12166	176	2	v	v	NOUN
ecj-12166	176	3	,	,	PUNCT
ecj-12166	176	4	lauchart	lauchart	PROPN
ecj-12166	176	5	m	m	PROPN
ecj-12166	176	6	,	,	PUNCT
ecj-12166	176	7	magerl	magerl	VERB
ecj-12166	176	8	w	w	PROPN
ecj-12166	176	9	,	,	PUNCT
ecj-12166	176	10	et	et	PROPN
ecj-12166	176	11	al	al	PROPN
ecj-12166	176	12	.	.	PUNCT
ecj-12166	177	1	effects	effect	NOUN
ecj-12166	177	2	of	of	ADP
ecj-12166	177	3	low	low	ADJ
ecj-12166	177	4	-	-	PUNCT
ecj-12166	177	5	dose	dose	NOUN
ecj-12166	177	6	intranasal	intranasal	NOUN
ecj-12166	177	7	(	(	PUNCT
ecj-12166	177	8	s)-ketamine	s)-ketamine	PUNCT
ecj-12166	177	9	in	in	ADP
ecj-12166	177	10	patients	patient	NOUN
ecj-12166	177	11	with	with	ADP
ecj-12166	177	12	neuropathic	neuropathic	ADJ
ecj-12166	177	13	pain	pain	NOUN
ecj-12166	177	14	.	.	PUNCT
ecj-12166	178	1	eur	eur	PROPN
ecj-12166	178	2	j	j	PROPN
ecj-12166	178	3	pain	pain	PROPN
ecj-12166	178	4	2010;14:387	2010;14:387	PROPN
ecj-12166	178	5	-	-	PUNCT
ecj-12166	178	6	94	94	NUM
ecj-12166	178	7	.	.	PUNCT
ecj-12166	179	1	31	31	NUM
ecj-12166	179	2	.	.	PUNCT
ecj-12166	180	1	oliveira	oliveira	PROPN
ecj-12166	180	2	je	je	PROPN
ecj-12166	180	3	silva	silva	PROPN
ecj-12166	180	4	l	l	PROPN
ecj-12166	180	5	,	,	PUNCT
ecj-12166	180	6	lee	lee	PROPN
ecj-12166	180	7	jy	jy	PROPN
ecj-12166	180	8	,	,	PUNCT
ecj-12166	180	9	bellolio	bellolio	NOUN
ecj-12166	180	10	f	f	NOUN
ecj-12166	180	11	,	,	PUNCT
ecj-12166	180	12	et	et	PROPN
ecj-12166	180	13	al	al	PROPN
ecj-12166	180	14	.	.	PROPN
ecj-12166	180	15	intranasal	intranasal	PROPN
ecj-12166	180	16	ketamine	ketamine	PROPN
ecj-12166	180	17	for	for	ADP
ecj-12166	180	18	acute	acute	ADJ
ecj-12166	180	19	pain	pain	NOUN
ecj-12166	180	20	management	management	NOUN
ecj-12166	180	21	in	in	ADP
ecj-12166	180	22	children	child	NOUN
ecj-12166	180	23	:	:	PUNCT
ecj-12166	180	24	a	a	DET
ecj-12166	180	25	systematic	systematic	ADJ
ecj-12166	180	26	review	review	NOUN
ecj-12166	180	27	and	and	CCONJ
ecj-12166	180	28	meta	meta	ADJ
ecj-12166	180	29	-	-	PUNCT
ecj-12166	180	30	analysis	analysis	NOUN
ecj-12166	180	31	.	.	PUNCT
ecj-12166	181	1	am	be	AUX
ecj-12166	181	2	j	j	PROPN
ecj-12166	181	3	emerg	emerg	PROPN
ecj-12166	181	4	med	med	PROPN
ecj-12166	181	5	2020;38:1860	2020;38:1860	PROPN
ecj-12166	181	6	-	-	SYM
ecj-12166	181	7	6	6	NUM
ecj-12166	181	8	.	.	NOUN
ecj-12166	181	9	32	32	NUM
ecj-12166	181	10	.	.	PUNCT
ecj-12166	182	1	rao	rao	PROPN
ecj-12166	182	2	lk	lk	PROPN
ecj-12166	182	3	,	,	PUNCT
ecj-12166	182	4	flaker	flaker	PROPN
ecj-12166	182	5	am	am	PROPN
ecj-12166	182	6	,	,	PUNCT
ecj-12166	182	7	friedel	friedel	PROPN
ecj-12166	182	8	cc	cc	PROPN
ecj-12166	182	9	,	,	PUNCT
ecj-12166	182	10	kharasch	kharasch	PROPN
ecj-12166	182	11	ed	ed	PROPN
ecj-12166	182	12	.	.	PUNCT
ecj-12166	183	1	role	role	NOUN
ecj-12166	183	2	of	of	ADP
ecj-12166	183	3	cytochrome	cytochrome	ADJ
ecj-12166	183	4	p4502b6	p4502b6	NOUN
ecj-12166	183	5	polymorphisms	polymorphism	NOUN
ecj-12166	183	6	in	in	ADP
ecj-12166	183	7	ketamine	ketamine	PROPN
ecj-12166	183	8	metabolism	metabolism	NOUN
ecj-12166	183	9	and	and	CCONJ
ecj-12166	183	10	clearance	clearance	NOUN
ecj-12166	183	11	.	.	PUNCT
ecj-12166	184	1	anesthesiology	anesthesiology	NOUN
ecj-12166	184	2	2016;125:110312	2016;125:110312	NUM
ecj-12166	184	3	.	.	PUNCT
ecj-12166	185	1	33	33	NUM
ecj-12166	185	2	.	.	PUNCT
ecj-12166	186	1	visser	visser	PROPN
ecj-12166	186	2	e	e	PROPN
ecj-12166	186	3	,	,	PUNCT
ecj-12166	186	4	schug	schug	NOUN
ecj-12166	186	5	sa	sa	PROPN
ecj-12166	186	6	.	.	PUNCT
ecj-12166	187	1	the	the	DET
ecj-12166	187	2	role	role	NOUN
ecj-12166	187	3	of	of	ADP
ecj-12166	187	4	ketamine	ketamine	PROPN
ecj-12166	187	5	in	in	ADP
ecj-12166	187	6	pain	pain	NOUN
ecj-12166	187	7	management	management	NOUN
ecj-12166	187	8	.	.	PUNCT
ecj-12166	187	9	biomed	biome	VERB
ecj-12166	187	10	pharmacother	pharmacother	ADJ
ecj-12166	187	11	2006;60:341	2006;60:341	NOUN
ecj-12166	187	12	-	-	X
ecj-12166	187	13	8	8	NUM
ecj-12166	187	14	.	.	PUNCT
ecj-12166	188	1	34	34	NUM
ecj-12166	188	2	.	.	PUNCT
ecj-12166	189	1	tran	tran	PROPN
ecj-12166	189	2	kp	kp	PROPN
ecj-12166	189	3	,	,	PUNCT
ecj-12166	189	4	nguyen	nguyen	PROPN
ecj-12166	189	5	q	q	X
ecj-12166	189	6	,	,	PUNCT
ecj-12166	189	7	truong	truong	PROPN
ecj-12166	189	8	xn	xn	PROPN
ecj-12166	189	9	,	,	PUNCT
ecj-12166	189	10	et	et	PROPN
ecj-12166	189	11	al	al	PROPN
ecj-12166	189	12	.	.	PUNCT
ecj-12166	190	1	a	a	DET
ecj-12166	190	2	comparison	comparison	NOUN
ecj-12166	190	3	of	of	ADP
ecj-12166	190	4	ketamine	ketamine	PROPN
ecj-12166	190	5	and	and	CCONJ
ecj-12166	190	6	morphine	morphine	VERB
ecj-12166	190	7	analgesia	analgesia	NOUN
ecj-12166	190	8	in	in	ADP
ecj-12166	190	9	prehospital	prehospital	ADJ
ecj-12166	190	10	trauma	trauma	NOUN
ecj-12166	190	11	care	care	NOUN
ecj-12166	190	12	:	:	PUNCT
ecj-12166	190	13	a	a	DET
ecj-12166	190	14	cluster	cluster	NOUN
ecj-12166	190	15	randomized	randomize	VERB
ecj-12166	190	16	clinical	clinical	ADJ
ecj-12166	190	17	trial	trial	NOUN
ecj-12166	190	18	in	in	ADP
ecj-12166	190	19	rural	rural	PROPN
ecj-12166	190	20	quang	quang	PROPN
ecj-12166	190	21	tri	tri	PROPN
ecj-12166	190	22	province	province	PROPN
ecj-12166	190	23	,	,	PUNCT
ecj-12166	190	24	vietnam	vietnam	PROPN
ecj-12166	190	25	.	.	PUNCT
ecj-12166	191	1	prehosp	prehosp	PROPN
ecj-12166	191	2	emerg	emerg	PROPN
ecj-12166	191	3	care	care	NOUN
ecj-12166	191	4	2014;18:257	2014;18:257	PROPN
ecj-12166	191	5	-	-	SYM
ecj-12166	191	6	64	64	NUM
ecj-12166	191	7	.	.	PUNCT
ecj-12166	191	8	35	35	NUM
ecj-12166	191	9	.	.	PUNCT
ecj-12166	192	1	green	green	PROPN
ecj-12166	192	2	sm	sm	PROPN
ecj-12166	192	3	,	,	PUNCT
ecj-12166	192	4	andolfatto	andolfatto	NOUN
ecj-12166	192	5	g	g	PROPN
ecj-12166	192	6	,	,	PUNCT
ecj-12166	192	7	krauss	krauss	PROPN
ecj-12166	192	8	bs	bs	PROPN
ecj-12166	192	9	.	.	PROPN
ecj-12166	192	10	ketamine	ketamine	PROPN
ecj-12166	192	11	and	and	CCONJ
ecj-12166	192	12	intracranial	intracranial	ADJ
ecj-12166	192	13	pressure	pressure	NOUN
ecj-12166	192	14	:	:	PUNCT
ecj-12166	192	15	no	no	DET
ecj-12166	192	16	contraindication	contraindication	NOUN
ecj-12166	192	17	except	except	SCONJ
ecj-12166	192	18	hydrocephalus	hydrocephalus	X
ecj-12166	192	19	.	.	PUNCT
ecj-12166	193	1	ann	ann	PROPN
ecj-12166	193	2	emerg	emerg	PROPN
ecj-12166	193	3	med	med	ADJ
ecj-12166	193	4	2015;65:52	2015;65:52	NUM
ecj-12166	193	5	-	-	SYM
ecj-12166	193	6	4	4	NUM
ecj-12166	193	7	.	.	NUM
ecj-12166	193	8	36	36	NUM
ecj-12166	193	9	.	.	PUNCT
ecj-12166	194	1	zeiler	zeiler	PROPN
ecj-12166	195	1	fa	fa	PROPN
ecj-12166	195	2	,	,	PUNCT
ecj-12166	195	3	teitelbaum	teitelbaum	PROPN
ecj-12166	195	4	j	j	PROPN
ecj-12166	195	5	,	,	PUNCT
ecj-12166	195	6	west	west	PROPN
ecj-12166	195	7	m	m	PROPN
ecj-12166	195	8	,	,	PUNCT
ecj-12166	195	9	gillman	gillman	PROPN
ecj-12166	195	10	lm	lm	PROPN
ecj-12166	195	11	.	.	PUNCT
ecj-12166	196	1	the	the	DET
ecj-12166	196	2	ketamine	ketamine	PROPN
ecj-12166	196	3	effect	effect	NOUN
ecj-12166	196	4	on	on	ADP
ecj-12166	196	5	icp	icp	PROPN
ecj-12166	196	6	in	in	ADP
ecj-12166	196	7	traumatic	traumatic	ADJ
ecj-12166	196	8	brain	brain	NOUN
ecj-12166	196	9	injury	injury	NOUN
ecj-12166	196	10	.	.	PUNCT
ecj-12166	197	1	neurocrit	neurocrit	NUM
ecj-12166	197	2	care	care	NOUN
ecj-12166	197	3	2014;21:163	2014;21:163	NUM
ecj-12166	197	4	-	-	SYM
ecj-12166	197	5	73	73	NUM
ecj-12166	197	6	.	.	PUNCT
ecj-12166	198	1	mini	mini	ADJ
ecj-12166	198	2	review	review	NOUN
ecj-12166	198	3	[	[	X
ecj-12166	198	4	page	page	NOUN
ecj-12166	198	5	34	34	NUM
ecj-12166	198	6	]	]	PUNCT
ecj-12166	199	1	[	[	X
ecj-12166	199	2	emergency	emergency	NOUN
ecj-12166	199	3	care	care	NOUN
ecj-12166	199	4	journal	journal	PROPN
ecj-12166	199	5	2024	2024	NUM
ecj-12166	199	6	;	;	PUNCT
ecj-12166	199	7	20:12166	20:12166	NUM
ecj-12166	199	8	]	]	X
ecj-12166	199	9	non	non	ADJ
ecj-12166	199	10	-co	-co	PROPN
ecj-12166	199	11	mmerc	mmerc	PROPN
ecj-12166	199	12	ial	ial	PROPN
ecj-12166	199	13	us	us	PROPN
ecj-12166	199	14	e	e	NOUN
ecj-12166	199	15	o	o	NOUN
ecj-12166	199	16	nly	nly	ADV
ecj-12166	199	17	37	37	NUM
ecj-12166	199	18	.	.	PUNCT
ecj-12166	200	1	godoy	godoy	PROPN
ecj-12166	200	2	da	da	PROPN
ecj-12166	200	3	,	,	PUNCT
ecj-12166	200	4	badenes	badene	VERB
ecj-12166	200	5	r	r	NOUN
ecj-12166	200	6	,	,	PUNCT
ecj-12166	200	7	pelosi	pelosi	PROPN
ecj-12166	200	8	p	p	NOUN
ecj-12166	200	9	,	,	PUNCT
ecj-12166	200	10	robba	robba	PROPN
ecj-12166	200	11	c.	c.	PROPN
ecj-12166	200	12	ketamine	ketamine	PROPN
ecj-12166	200	13	in	in	ADP
ecj-12166	200	14	acute	acute	ADJ
ecj-12166	200	15	phase	phase	NOUN
ecj-12166	200	16	of	of	ADP
ecj-12166	200	17	severe	severe	ADJ
ecj-12166	200	18	traumatic	traumatic	ADJ
ecj-12166	200	19	brain	brain	NOUN
ecj-12166	200	20	injury	injury	NOUN
ecj-12166	200	21	‘	'	PUNCT
ecj-12166	200	22	an	an	DET
ecj-12166	200	23	old	old	ADJ
ecj-12166	200	24	drug	drug	NOUN
ecj-12166	200	25	for	for	ADP
ecj-12166	200	26	new	new	ADJ
ecj-12166	200	27	uses	use	NOUN
ecj-12166	200	28	?	?	PUNCT
ecj-12166	200	29	’	'	PUNCT
ecj-12166	200	30	.	.	PUNCT
ecj-12166	201	1	crit	crit	PROPN
ecj-12166	201	2	care	care	PROPN
ecj-12166	201	3	2021;25:19	2021;25:19	NUM
ecj-12166	201	4	.	.	PUNCT
ecj-12166	202	1	38	38	NUM
ecj-12166	202	2	.	.	PUNCT
ecj-12166	203	1	laws	law	NOUN
ecj-12166	203	2	jc	jc	PROPN
ecj-12166	203	3	,	,	PUNCT
ecj-12166	203	4	vance	vance	PROPN
ecj-12166	203	5	eh	eh	INTJ
ecj-12166	203	6	,	,	PUNCT
ecj-12166	203	7	betters	betters	PROPN
ecj-12166	203	8	ka	ka	PROPN
ecj-12166	203	9	,	,	PUNCT
ecj-12166	203	10	et	et	PROPN
ecj-12166	203	11	al	al	PROPN
ecj-12166	203	12	.	.	PUNCT
ecj-12166	204	1	acute	acute	PROPN
ecj-12166	204	2	effects	effect	NOUN
ecj-12166	204	3	of	of	ADP
ecj-12166	204	4	ketamine	ketamine	PROPN
ecj-12166	204	5	on	on	ADP
ecj-12166	204	6	intracranial	intracranial	ADJ
ecj-12166	204	7	pressure	pressure	NOUN
ecj-12166	204	8	in	in	ADP
ecj-12166	204	9	children	child	NOUN
ecj-12166	204	10	with	with	ADP
ecj-12166	204	11	severe	severe	ADJ
ecj-12166	204	12	traumatic	traumatic	ADJ
ecj-12166	204	13	brain	brain	NOUN
ecj-12166	204	14	injury	injury	NOUN
ecj-12166	204	15	.	.	PUNCT
ecj-12166	205	1	crit	crit	PROPN
ecj-12166	205	2	care	care	PROPN
ecj-12166	205	3	med	me	VERB
ecj-12166	205	4	2023;51:563	2023;51:563	NUM
ecj-12166	205	5	-	-	SYM
ecj-12166	205	6	72	72	NUM
ecj-12166	205	7	.	.	NOUN
ecj-12166	205	8	39	39	NUM
ecj-12166	205	9	.	.	PUNCT
ecj-12166	206	1	dyal	dyal	PROPN
ecj-12166	206	2	s	s	PROPN
ecj-12166	206	3	,	,	PUNCT
ecj-12166	206	4	maclaren	maclaren	PROPN
ecj-12166	206	5	r.	r.	PROPN
ecj-12166	206	6	the	the	DET
ecj-12166	206	7	assessment	assessment	NOUN
ecj-12166	206	8	and	and	CCONJ
ecj-12166	206	9	management	management	NOUN
ecj-12166	206	10	practices	practice	NOUN
ecj-12166	206	11	of	of	ADP
ecj-12166	206	12	acute	acute	ADJ
ecj-12166	206	13	alcohol	alcohol	NOUN
ecj-12166	206	14	withdrawal	withdrawal	NOUN
ecj-12166	206	15	:	:	PUNCT
ecj-12166	206	16	results	result	NOUN
ecj-12166	206	17	of	of	ADP
ecj-12166	206	18	a	a	DET
ecj-12166	206	19	nationwide	nationwide	ADJ
ecj-12166	206	20	survey	survey	NOUN
ecj-12166	206	21	of	of	ADP
ecj-12166	206	22	critical	critical	ADJ
ecj-12166	206	23	care	care	NOUN
ecj-12166	206	24	pharmacists	pharmacist	NOUN
ecj-12166	206	25	.	.	PUNCT
ecj-12166	207	1	hosp	hosp	PROPN
ecj-12166	207	2	pharm	pharm	PROPN
ecj-12166	207	3	2019;54:22	2019;54:22	NUM
ecj-12166	207	4	-	-	SYM
ecj-12166	207	5	31	31	NUM
ecj-12166	207	6	.	.	PUNCT
ecj-12166	207	7	40	40	NUM
ecj-12166	207	8	.	.	PUNCT
ecj-12166	208	1	linder	linder	PROPN
ecj-12166	208	2	lm	lm	PROPN
ecj-12166	208	3	,	,	PUNCT
ecj-12166	208	4	ross	ross	PROPN
ecj-12166	208	5	ca	ca	PROPN
ecj-12166	208	6	,	,	PUNCT
ecj-12166	208	7	weant	weant	ADJ
ecj-12166	208	8	ka	ka	PROPN
ecj-12166	208	9	.	.	PROPN
ecj-12166	208	10	ketamine	ketamine	PROPN
ecj-12166	208	11	for	for	ADP
ecj-12166	208	12	the	the	DET
ecj-12166	208	13	acute	acute	ADJ
ecj-12166	208	14	management	management	NOUN
ecj-12166	208	15	of	of	ADP
ecj-12166	208	16	excited	excited	ADJ
ecj-12166	208	17	delirium	delirium	NOUN
ecj-12166	208	18	and	and	CCONJ
ecj-12166	208	19	agitation	agitation	NOUN
ecj-12166	208	20	in	in	ADP
ecj-12166	208	21	the	the	DET
ecj-12166	208	22	prehospital	prehospital	NOUN
ecj-12166	208	23	setting	setting	NOUN
ecj-12166	208	24	.	.	PUNCT
ecj-12166	209	1	pharmacotherapy	pharmacotherapy	NOUN
ecj-12166	209	2	2018;38:139	2018;38:139	NOUN
ecj-12166	209	3	-	-	SYM
ecj-12166	209	4	51	51	NUM
ecj-12166	209	5	.	.	NOUN
ecj-12166	209	6	41	41	NUM
ecj-12166	209	7	.	.	PUNCT
ecj-12166	210	1	long	long	ADJ
ecj-12166	210	2	d	d	NOUN
ecj-12166	210	3	,	,	PUNCT
ecj-12166	210	4	long	long	ADJ
ecj-12166	210	5	b	b	NOUN
ecj-12166	210	6	,	,	PUNCT
ecj-12166	210	7	koyfman	koyfman	ADJ
ecj-12166	210	8	a.	a.	NOUN
ecj-12166	210	9	the	the	DET
ecj-12166	210	10	emergency	emergency	NOUN
ecj-12166	210	11	medicine	medicine	NOUN
ecj-12166	210	12	management	management	NOUN
ecj-12166	210	13	of	of	ADP
ecj-12166	210	14	severe	severe	ADJ
ecj-12166	210	15	alcohol	alcohol	NOUN
ecj-12166	210	16	withdrawal	withdrawal	NOUN
ecj-12166	210	17	.	.	PUNCT
ecj-12166	211	1	am	be	AUX
ecj-12166	211	2	j	j	PROPN
ecj-12166	211	3	emerg	emerg	PROPN
ecj-12166	211	4	med	med	PROPN
ecj-12166	211	5	2017;35:1005	2017;35:1005	PROPN
ecj-12166	211	6	-	-	SYM
ecj-12166	211	7	11	11	NUM
ecj-12166	211	8	.	.	PUNCT
ecj-12166	212	1	42	42	NUM
ecj-12166	212	2	.	.	PUNCT
ecj-12166	213	1	strayer	strayer	PROPN
ecj-12166	213	2	rj	rj	PROPN
ecj-12166	213	3	,	,	PUNCT
ecj-12166	213	4	friedman	friedman	PROPN
ecj-12166	213	5	bw	bw	PROPN
ecj-12166	213	6	,	,	PUNCT
ecj-12166	213	7	haroz	haroz	ADV
ecj-12166	213	8	r	r	NOUN
ecj-12166	213	9	,	,	PUNCT
ecj-12166	213	10	et	et	PROPN
ecj-12166	213	11	al	al	PROPN
ecj-12166	213	12	.	.	PUNCT
ecj-12166	213	13	emergency	emergency	PROPN
ecj-12166	213	14	department	department	PROPN
ecj-12166	213	15	management	management	NOUN
ecj-12166	213	16	of	of	ADP
ecj-12166	213	17	patients	patient	NOUN
ecj-12166	213	18	with	with	ADP
ecj-12166	213	19	alcohol	alcohol	NOUN
ecj-12166	213	20	intoxication	intoxication	NOUN
ecj-12166	213	21	,	,	PUNCT
ecj-12166	213	22	alcohol	alcohol	NOUN
ecj-12166	213	23	withdrawal	withdrawal	NOUN
ecj-12166	213	24	,	,	PUNCT
ecj-12166	213	25	and	and	CCONJ
ecj-12166	213	26	alcohol	alcohol	NOUN
ecj-12166	213	27	use	use	NOUN
ecj-12166	213	28	disorder	disorder	NOUN
ecj-12166	213	29	:	:	PUNCT
ecj-12166	213	30	a	a	DET
ecj-12166	213	31	white	white	ADJ
ecj-12166	213	32	paper	paper	NOUN
ecj-12166	213	33	prepared	prepare	VERB
ecj-12166	213	34	for	for	ADP
ecj-12166	213	35	the	the	DET
ecj-12166	213	36	american	american	PROPN
ecj-12166	213	37	academy	academy	PROPN
ecj-12166	213	38	of	of	ADP
ecj-12166	213	39	emergency	emergency	NOUN
ecj-12166	213	40	medicine	medicine	NOUN
ecj-12166	213	41	.	.	PUNCT
ecj-12166	214	1	j	j	PROPN
ecj-12166	214	2	emerg	emerg	PROPN
ecj-12166	214	3	med	med	ADJ
ecj-12166	214	4	2023;64:517	2023;64:517	PROPN
ecj-12166	214	5	-	-	SYM
ecj-12166	214	6	40	40	NUM
ecj-12166	214	7	.	.	PUNCT
ecj-12166	215	1	43	43	NUM
ecj-12166	215	2	.	.	PUNCT
ecj-12166	216	1	goldfine	goldfine	PROPN
ecj-12166	216	2	ce	ce	PROPN
ecj-12166	216	3	,	,	PUNCT
ecj-12166	216	4	tom	tom	PROPN
ecj-12166	216	5	jj	jj	PROPN
ecj-12166	216	6	,	,	PUNCT
ecj-12166	216	7	i	i	PRON
ecj-12166	216	8	m	m	VERB
ecj-12166	216	9	dd	dd	ADJ
ecj-12166	216	10	,	,	PUNCT
ecj-12166	216	11	et	et	PROPN
ecj-12166	216	12	al	al	PROPN
ecj-12166	216	13	.	.	PUNCT
ecj-12166	217	1	the	the	DET
ecj-12166	217	2	therapeutic	therapeutic	ADJ
ecj-12166	217	3	use	use	NOUN
ecj-12166	217	4	and	and	CCONJ
ecj-12166	217	5	efficacy	efficacy	NOUN
ecj-12166	217	6	of	of	ADP
ecj-12166	217	7	ketamine	ketamine	PROPN
ecj-12166	217	8	in	in	ADP
ecj-12166	217	9	alcohol	alcohol	NOUN
ecj-12166	217	10	use	use	NOUN
ecj-12166	217	11	disorder	disorder	NOUN
ecj-12166	217	12	and	and	CCONJ
ecj-12166	217	13	alcohol	alcohol	NOUN
ecj-12166	217	14	withdrawal	withdrawal	NOUN
ecj-12166	217	15	syndrome	syndrome	PROPN
ecj-12166	217	16	:	:	PUNCT
ecj-12166	217	17	a	a	DET
ecj-12166	217	18	scoping	scope	VERB
ecj-12166	217	19	review	review	NOUN
ecj-12166	217	20	.	.	PUNCT
ecj-12166	218	1	front	front	ADJ
ecj-12166	218	2	psychiatry	psychiatry	NOUN
ecj-12166	218	3	2023;14:1141836	2023;14:1141836	NUM
ecj-12166	218	4	.	.	PROPN
ecj-12166	218	5	44	44	NUM
ecj-12166	218	6	.	.	PUNCT
ecj-12166	219	1	shah	shah	PROPN
ecj-12166	219	2	p	p	PROPN
ecj-12166	219	3	,	,	PUNCT
ecj-12166	219	4	mcdowell	mcdowell	PROPN
ecj-12166	219	5	m	m	PROPN
ecj-12166	219	6	,	,	PUNCT
ecj-12166	219	7	ebisu	ebisu	PROPN
ecj-12166	219	8	r	r	PROPN
ecj-12166	219	9	,	,	PUNCT
ecj-12166	219	10	et	et	PROPN
ecj-12166	219	11	al	al	PROPN
ecj-12166	219	12	.	.	PROPN
ecj-12166	219	13	adjunctive	adjunctive	ADJ
ecj-12166	219	14	use	use	NOUN
ecj-12166	219	15	of	of	ADP
ecj-12166	219	16	ketamine	ketamine	PROPN
ecj-12166	219	17	for	for	ADP
ecj-12166	219	18	benzodiazepine	benzodiazepine	NOUN
ecj-12166	219	19	-	-	PUNCT
ecj-12166	219	20	resistant	resistant	ADJ
ecj-12166	219	21	severe	severe	ADJ
ecj-12166	219	22	alcohol	alcohol	NOUN
ecj-12166	219	23	withdrawal	withdrawal	NOUN
ecj-12166	219	24	:	:	PUNCT
ecj-12166	219	25	a	a	DET
ecj-12166	219	26	retrospective	retrospective	ADJ
ecj-12166	219	27	evaluation	evaluation	NOUN
ecj-12166	219	28	.	.	PUNCT
ecj-12166	220	1	j	j	PROPN
ecj-12166	220	2	med	med	PROPN
ecj-12166	220	3	toxicol	toxicol	PROPN
ecj-12166	220	4	2018;14:229	2018;14:229	NUM
ecj-12166	220	5	-	-	SYM
ecj-12166	220	6	36	36	NUM
ecj-12166	220	7	.	.	PUNCT
ecj-12166	221	1	45	45	NUM
ecj-12166	221	2	.	.	NOUN
ecj-12166	221	3	garel	garel	PROPN
ecj-12166	221	4	n	n	CCONJ
ecj-12166	221	5	,	,	PUNCT
ecj-12166	221	6	mcanulty	mcanulty	NOUN
ecj-12166	221	7	c	c	NOUN
ecj-12166	221	8	,	,	PUNCT
ecj-12166	221	9	greenway	greenway	PROPN
ecj-12166	221	10	kt	kt	PROPN
ecj-12166	221	11	,	,	PUNCT
ecj-12166	221	12	et	et	PROPN
ecj-12166	221	13	al	al	PROPN
ecj-12166	221	14	.	.	PROPN
ecj-12166	221	15	efficacy	efficacy	PROPN
ecj-12166	221	16	of	of	ADP
ecj-12166	221	17	ketamine	ketamine	PROPN
ecj-12166	221	18	intervention	intervention	NOUN
ecj-12166	221	19	to	to	PART
ecj-12166	221	20	decrease	decrease	VERB
ecj-12166	221	21	alcohol	alcohol	NOUN
ecj-12166	221	22	use	use	NOUN
ecj-12166	221	23	,	,	PUNCT
ecj-12166	221	24	cravings	craving	NOUN
ecj-12166	221	25	,	,	PUNCT
ecj-12166	221	26	and	and	CCONJ
ecj-12166	221	27	withdrawal	withdrawal	NOUN
ecj-12166	221	28	symptoms	symptom	NOUN
ecj-12166	221	29	in	in	ADP
ecj-12166	221	30	adults	adult	NOUN
ecj-12166	221	31	with	with	ADP
ecj-12166	221	32	problematic	problematic	ADJ
ecj-12166	221	33	alcohol	alcohol	NOUN
ecj-12166	221	34	use	use	NOUN
ecj-12166	221	35	or	or	CCONJ
ecj-12166	221	36	alcohol	alcohol	NOUN
ecj-12166	221	37	use	use	NOUN
ecj-12166	221	38	disorder	disorder	NOUN
ecj-12166	221	39	:	:	PUNCT
ecj-12166	221	40	a	a	DET
ecj-12166	221	41	systematic	systematic	ADJ
ecj-12166	221	42	review	review	NOUN
ecj-12166	221	43	and	and	CCONJ
ecj-12166	221	44	comprehensive	comprehensive	ADJ
ecj-12166	221	45	analysis	analysis	NOUN
ecj-12166	221	46	of	of	ADP
ecj-12166	221	47	mechanism	mechanism	NOUN
ecj-12166	221	48	of	of	ADP
ecj-12166	221	49	actions	action	NOUN
ecj-12166	221	50	.	.	PUNCT
ecj-12166	222	1	drug	drug	NOUN
ecj-12166	222	2	alcohol	alcohol	NOUN
ecj-12166	222	3	depend	depend	VERB
ecj-12166	222	4	2022;239:109606	2022;239:109606	NUM
ecj-12166	222	5	.	.	PUNCT
ecj-12166	223	1	46	46	NUM
ecj-12166	223	2	.	.	PUNCT
ecj-12166	224	1	kelson	kelson	PROPN
ecj-12166	224	2	m	m	PROPN
ecj-12166	224	3	,	,	PUNCT
ecj-12166	224	4	burnett	burnett	PROPN
ecj-12166	224	5	jm	jm	PROPN
ecj-12166	224	6	,	,	PUNCT
ecj-12166	224	7	matthews	matthews	PROPN
ecj-12166	224	8	a	a	PRON
ecj-12166	224	9	,	,	PUNCT
ecj-12166	224	10	juneja	juneja	ADJ
ecj-12166	224	11	t.	t.	PROPN
ecj-12166	224	12	ketamine	ketamine	PROPN
ecj-12166	224	13	treatment	treatment	NOUN
ecj-12166	224	14	for	for	ADP
ecj-12166	224	15	alcohol	alcohol	NOUN
ecj-12166	224	16	use	use	NOUN
ecj-12166	224	17	disorder	disorder	NOUN
ecj-12166	224	18	:	:	PUNCT
ecj-12166	224	19	a	a	DET
ecj-12166	224	20	systematic	systematic	ADJ
ecj-12166	224	21	review	review	NOUN
ecj-12166	224	22	.	.	PUNCT
ecj-12166	225	1	cureus	cureus	PROPN
ecj-12166	225	2	2023;15	2023;15	NUM
ecj-12166	225	3	:	:	PUNCT
ecj-12166	225	4	e38498	e38498	PROPN
ecj-12166	225	5	.	.	PUNCT
ecj-12166	226	1	47	47	NUM
ecj-12166	226	2	.	.	PUNCT
ecj-12166	227	1	cohen	cohen	PROPN
ecj-12166	227	2	sp	sp	PROPN
ecj-12166	227	3	,	,	PUNCT
ecj-12166	227	4	bhatia	bhatia	PROPN
ecj-12166	227	5	a	a	PRON
ecj-12166	227	6	,	,	PUNCT
ecj-12166	227	7	buvanendran	buvanendran	VERB
ecj-12166	227	8	a	a	PRON
ecj-12166	227	9	,	,	PUNCT
ecj-12166	227	10	et	et	PROPN
ecj-12166	227	11	al	al	PROPN
ecj-12166	227	12	.	.	PUNCT
ecj-12166	228	1	consensus	consensus	NOUN
ecj-12166	228	2	guidelines	guideline	NOUN
ecj-12166	228	3	on	on	ADP
ecj-12166	228	4	the	the	DET
ecj-12166	228	5	use	use	NOUN
ecj-12166	228	6	of	of	ADP
ecj-12166	228	7	intravenous	intravenous	ADJ
ecj-12166	228	8	ketamine	ketamine	PROPN
ecj-12166	228	9	infusions	infusion	NOUN
ecj-12166	228	10	for	for	ADP
ecj-12166	228	11	chronic	chronic	ADJ
ecj-12166	228	12	pain	pain	NOUN
ecj-12166	228	13	from	from	ADP
ecj-12166	228	14	the	the	DET
ecj-12166	228	15	american	american	ADJ
ecj-12166	228	16	society	society	NOUN
ecj-12166	228	17	of	of	ADP
ecj-12166	228	18	regional	regional	ADJ
ecj-12166	228	19	anesthesia	anesthesia	NOUN
ecj-12166	228	20	and	and	CCONJ
ecj-12166	228	21	pain	pain	NOUN
ecj-12166	228	22	medicine	medicine	NOUN
ecj-12166	228	23	,	,	PUNCT
ecj-12166	228	24	the	the	DET
ecj-12166	228	25	american	american	PROPN
ecj-12166	228	26	academy	academy	PROPN
ecj-12166	228	27	of	of	ADP
ecj-12166	228	28	pain	pain	NOUN
ecj-12166	228	29	medicine	medicine	NOUN
ecj-12166	228	30	,	,	PUNCT
ecj-12166	228	31	and	and	CCONJ
ecj-12166	228	32	the	the	DET
ecj-12166	228	33	american	american	ADJ
ecj-12166	228	34	society	society	NOUN
ecj-12166	228	35	of	of	ADP
ecj-12166	228	36	anesthesiologists	anesthesiologists	PROPN
ecj-12166	228	37	.	.	PUNCT
ecj-12166	229	1	reg	reg	PROPN
ecj-12166	229	2	anesth	anesth	PROPN
ecj-12166	229	3	pain	pain	NOUN
ecj-12166	229	4	med	med	ADJ
ecj-12166	229	5	2018;43:521	2018;43:521	PROPN
ecj-12166	229	6	-	-	SYM
ecj-12166	229	7	46	46	NUM
ecj-12166	229	8	48	48	NUM
ecj-12166	229	9	.	.	PUNCT
ecj-12166	230	1	schwenk	schwenk	PROPN
ecj-12166	230	2	es	es	PROPN
ecj-12166	230	3	,	,	PUNCT
ecj-12166	230	4	pradhan	pradhan	PROPN
ecj-12166	230	5	b	b	PROPN
ecj-12166	230	6	,	,	PUNCT
ecj-12166	230	7	nalamasu	nalamasu	NOUN
ecj-12166	230	8	r	r	NOUN
ecj-12166	230	9	,	,	PUNCT
ecj-12166	230	10	et	et	PROPN
ecj-12166	230	11	al	al	PROPN
ecj-12166	230	12	.	.	PROPN
ecj-12166	230	13	ketamine	ketamine	PROPN
ecj-12166	230	14	in	in	ADP
ecj-12166	230	15	the	the	DET
ecj-12166	230	16	past	past	NOUN
ecj-12166	230	17	,	,	PUNCT
ecj-12166	230	18	present	present	ADJ
ecj-12166	230	19	,	,	PUNCT
ecj-12166	230	20	and	and	CCONJ
ecj-12166	230	21	future	future	ADJ
ecj-12166	230	22	:	:	PUNCT
ecj-12166	230	23	mechanisms	mechanism	NOUN
ecj-12166	230	24	,	,	PUNCT
ecj-12166	230	25	metabolites	metabolite	NOUN
ecj-12166	230	26	,	,	PUNCT
ecj-12166	230	27	and	and	CCONJ
ecj-12166	230	28	toxicity	toxicity	NOUN
ecj-12166	230	29	.	.	PUNCT
ecj-12166	231	1	curr	curr	PROPN
ecj-12166	231	2	pain	pain	PROPN
ecj-12166	231	3	headache	headache	PROPN
ecj-12166	231	4	rep	rep	PROPN
ecj-12166	231	5	2021;25:57	2021;25:57	PROPN
ecj-12166	231	6	.	.	PROPN
ecj-12166	232	1	49	49	NUM
ecj-12166	232	2	.	.	PUNCT
ecj-12166	233	1	pourmand	pourmand	PROPN
ecj-12166	233	2	a	a	X
ecj-12166	233	3	,	,	PUNCT
ecj-12166	233	4	mazer	mazer	PROPN
ecj-12166	233	5	-	-	PUNCT
ecj-12166	233	6	amirshahi	amirshahi	PROPN
ecj-12166	233	7	m	m	PROPN
ecj-12166	233	8	,	,	PUNCT
ecj-12166	233	9	royall	royall	NOUN
ecj-12166	233	10	c	c	PROPN
ecj-12166	233	11	,	,	PUNCT
ecj-12166	233	12	alhawas	alhawas	ADJ
ecj-12166	233	13	r	r	NOUN
ecj-12166	233	14	,	,	PUNCT
ecj-12166	233	15	shesser	shesser	PROPN
ecj-12166	233	16	r.	r.	PROPN
ecj-12166	233	17	low	low	PROPN
ecj-12166	233	18	dose	dose	PROPN
ecj-12166	233	19	ketamine	ketamine	PROPN
ecj-12166	233	20	use	use	NOUN
ecj-12166	233	21	in	in	ADP
ecj-12166	233	22	the	the	DET
ecj-12166	233	23	emergency	emergency	NOUN
ecj-12166	233	24	department	department	NOUN
ecj-12166	233	25	,	,	PUNCT
ecj-12166	233	26	a	a	DET
ecj-12166	233	27	new	new	ADJ
ecj-12166	233	28	direction	direction	NOUN
ecj-12166	233	29	in	in	ADP
ecj-12166	233	30	pain	pain	NOUN
ecj-12166	233	31	management	management	NOUN
ecj-12166	233	32	.	.	PUNCT
ecj-12166	234	1	am	be	AUX
ecj-12166	234	2	j	j	PROPN
ecj-12166	234	3	emerg	emerg	PROPN
ecj-12166	234	4	med	med	PROPN
ecj-12166	234	5	2017;35:918	2017;35:918	PROPN
ecj-12166	234	6	-	-	SYM
ecj-12166	234	7	21	21	NUM
ecj-12166	234	8	.	.	PUNCT
ecj-12166	235	1	50	50	NUM
ecj-12166	235	2	.	.	PUNCT
ecj-12166	236	1	subramanian	subramanian	PROPN
ecj-12166	236	2	s	s	PROPN
ecj-12166	236	3	,	,	PUNCT
ecj-12166	236	4	haroutounian	haroutounian	PROPN
ecj-12166	236	5	s	s	PROPN
ecj-12166	236	6	,	,	PUNCT
ecj-12166	236	7	palanca	palanca	PROPN
ecj-12166	236	8	bja	bja	PROPN
ecj-12166	236	9	,	,	PUNCT
ecj-12166	236	10	lenze	lenze	PROPN
ecj-12166	236	11	ej	ej	PROPN
ecj-12166	236	12	.	.	PROPN
ecj-12166	236	13	ketamine	ketamine	PROPN
ecj-12166	236	14	as	as	ADP
ecj-12166	236	15	a	a	DET
ecj-12166	236	16	therapeutic	therapeutic	ADJ
ecj-12166	236	17	agent	agent	NOUN
ecj-12166	236	18	for	for	ADP
ecj-12166	236	19	depression	depression	NOUN
ecj-12166	236	20	and	and	CCONJ
ecj-12166	236	21	pain	pain	NOUN
ecj-12166	236	22	:	:	PUNCT
ecj-12166	236	23	mechanisms	mechanism	NOUN
ecj-12166	236	24	and	and	CCONJ
ecj-12166	236	25	evidence	evidence	NOUN
ecj-12166	236	26	.	.	PUNCT
ecj-12166	237	1	j	j	PROPN
ecj-12166	237	2	neurol	neurol	PROPN
ecj-12166	237	3	sci	sci	PROPN
ecj-12166	237	4	2022;434:120152	2022;434:120152	NUM
ecj-12166	237	5	.	.	PUNCT
ecj-12166	238	1	51	51	NUM
ecj-12166	238	2	.	.	PUNCT
ecj-12166	239	1	orhurhu	orhurhu	PROPN
ecj-12166	239	2	vj	vj	PROPN
ecj-12166	239	3	,	,	PUNCT
ecj-12166	239	4	roberts	roberts	PROPN
ecj-12166	239	5	js	js	PROPN
ecj-12166	239	6	,	,	PUNCT
ecj-12166	239	7	ly	ly	ADP
ecj-12166	239	8	n	n	CCONJ
ecj-12166	239	9	,	,	PUNCT
ecj-12166	239	10	cohen	cohen	PROPN
ecj-12166	239	11	sp	sp	PROPN
ecj-12166	239	12	.	.	PROPN
ecj-12166	239	13	ketamine	ketamine	PROPN
ecj-12166	239	14	in	in	ADP
ecj-12166	239	15	acute	acute	ADJ
ecj-12166	239	16	and	and	CCONJ
ecj-12166	239	17	chronic	chronic	ADJ
ecj-12166	239	18	pain	pain	NOUN
ecj-12166	239	19	management	management	NOUN
ecj-12166	239	20	.	.	PUNCT
ecj-12166	240	1	statpearls	statpearl	NOUN
ecj-12166	240	2	2023	2023	NUM
ecj-12166	240	3	.	.	PUNCT
ecj-12166	241	1	52	52	NUM
ecj-12166	241	2	.	.	PUNCT
ecj-12166	242	1	childers	childer	NOUN
ecj-12166	242	2	we	we	PRON
ecj-12166	242	3	,	,	PUNCT
ecj-12166	242	4	baudy	baudy	PROPN
ecj-12166	242	5	rb	rb	PROPN
ecj-12166	242	6	.	.	PROPN
ecj-12166	242	7	n	n	CCONJ
ecj-12166	242	8	-	-	PUNCT
ecj-12166	242	9	methyl	methyl	NOUN
ecj-12166	242	10	-	-	PUNCT
ecj-12166	242	11	d	d	NOUN
ecj-12166	242	12	-	-	PUNCT
ecj-12166	242	13	aspartate	aspartate	ADJ
ecj-12166	242	14	antagonists	antagonist	NOUN
ecj-12166	242	15	and	and	CCONJ
ecj-12166	242	16	neuropathic	neuropathic	ADJ
ecj-12166	242	17	pain	pain	NOUN
ecj-12166	242	18	:	:	PUNCT
ecj-12166	242	19	the	the	DET
ecj-12166	242	20	search	search	NOUN
ecj-12166	242	21	for	for	ADP
ecj-12166	242	22	relief	relief	NOUN
ecj-12166	242	23	.	.	PUNCT
ecj-12166	243	1	j	j	PROPN
ecj-12166	243	2	med	med	ADJ
ecj-12166	243	3	chem	chem	NOUN
ecj-12166	243	4	2007;50:2557	2007;50:2557	NUM
ecj-12166	243	5	-	-	SYM
ecj-12166	243	6	62	62	NUM
ecj-12166	243	7	.	.	PUNCT
ecj-12166	244	1	53	53	NUM
ecj-12166	244	2	.	.	PUNCT
ecj-12166	245	1	serra	serra	PROPN
ecj-12166	245	2	s	s	PROPN
ecj-12166	245	3	,	,	PUNCT
ecj-12166	245	4	spampinato	spampinato	PROPN
ecj-12166	245	5	md	md	PROPN
ecj-12166	245	6	,	,	PUNCT
ecj-12166	245	7	riccardi	riccardi	VERB
ecj-12166	245	8	a	a	PRON
ecj-12166	245	9	,	,	PUNCT
ecj-12166	245	10	et	et	PROPN
ecj-12166	245	11	al	al	PROPN
ecj-12166	245	12	.	.	PUNCT
ecj-12166	245	13	pain	pain	NOUN
ecj-12166	245	14	management	management	NOUN
ecj-12166	245	15	at	at	ADP
ecj-12166	245	16	the	the	DET
ecj-12166	245	17	end	end	NOUN
ecj-12166	245	18	of	of	ADP
ecj-12166	245	19	life	life	NOUN
ecj-12166	245	20	in	in	ADP
ecj-12166	245	21	the	the	DET
ecj-12166	245	22	emergency	emergency	NOUN
ecj-12166	245	23	department	department	NOUN
ecj-12166	245	24	:	:	PUNCT
ecj-12166	245	25	a	a	DET
ecj-12166	245	26	narrative	narrative	NOUN
ecj-12166	245	27	review	review	NOUN
ecj-12166	245	28	of	of	ADP
ecj-12166	245	29	the	the	DET
ecj-12166	245	30	literature	literature	NOUN
ecj-12166	245	31	and	and	CCONJ
ecj-12166	245	32	a	a	DET
ecj-12166	245	33	practical	practical	ADJ
ecj-12166	245	34	clinical	clinical	ADJ
ecj-12166	245	35	approach	approach	NOUN
ecj-12166	245	36	.	.	PUNCT
ecj-12166	246	1	j	j	PROPN
ecj-12166	246	2	clin	clin	PROPN
ecj-12166	246	3	med	me	VERB
ecj-12166	246	4	2023;12:4357	2023;12:4357	NUM
ecj-12166	246	5	.	.	PROPN
ecj-12166	247	1	54	54	NUM
ecj-12166	247	2	.	.	PUNCT
ecj-12166	248	1	goldman	goldman	PROPN
ecj-12166	248	2	n	n	PROPN
ecj-12166	248	3	,	,	PUNCT
ecj-12166	248	4	frankenthaler	frankenthaler	PROPN
ecj-12166	248	5	m	m	PROPN
ecj-12166	248	6	,	,	PUNCT
ecj-12166	248	7	klepacz	klepacz	PROPN
ecj-12166	248	8	l.	l.	PROPN
ecj-12166	248	9	the	the	DET
ecj-12166	248	10	efficacy	efficacy	NOUN
ecj-12166	248	11	of	of	ADP
ecj-12166	248	12	ketamine	ketamine	PROPN
ecj-12166	248	13	in	in	ADP
ecj-12166	248	14	the	the	DET
ecj-12166	248	15	palliative	palliative	ADJ
ecj-12166	248	16	care	care	NOUN
ecj-12166	248	17	setting	set	VERB
ecj-12166	248	18	:	:	PUNCT
ecj-12166	248	19	a	a	DET
ecj-12166	248	20	comprehensive	comprehensive	ADJ
ecj-12166	248	21	review	review	NOUN
ecj-12166	248	22	of	of	ADP
ecj-12166	248	23	the	the	DET
ecj-12166	248	24	literature	literature	NOUN
ecj-12166	248	25	.	.	PUNCT
ecj-12166	249	1	j	j	PROPN
ecj-12166	249	2	palliat	palliat	VERB
ecj-12166	249	3	med	med	PROPN
ecj-12166	249	4	2019;22:1154	2019;22:1154	PROPN
ecj-12166	249	5	-	-	SYM
ecj-12166	249	6	61	61	NUM
ecj-12166	249	7	.	.	PUNCT
ecj-12166	250	1	55	55	NUM
ecj-12166	250	2	.	.	PUNCT
ecj-12166	250	3	binsaeedu	binsaeedu	VERB
ecj-12166	250	4	as	as	ADP
ecj-12166	250	5	,	,	PUNCT
ecj-12166	250	6	prabakar	prabakar	NOUN
ecj-12166	250	7	d	d	PROPN
ecj-12166	250	8	,	,	PUNCT
ecj-12166	250	9	ashkar	ashkar	PROPN
ecj-12166	250	10	m	m	PROPN
ecj-12166	250	11	,	,	PUNCT
ecj-12166	250	12	et	et	PROPN
ecj-12166	250	13	al	al	PROPN
ecj-12166	250	14	.	.	PUNCT
ecj-12166	250	15	evaluating	evaluate	VERB
ecj-12166	250	16	the	the	DET
ecj-12166	250	17	safety	safety	NOUN
ecj-12166	250	18	and	and	CCONJ
ecj-12166	250	19	efficacy	efficacy	NOUN
ecj-12166	250	20	of	of	ADP
ecj-12166	250	21	ketamine	ketamine	PROPN
ecj-12166	250	22	as	as	ADP
ecj-12166	250	23	a	a	DET
ecj-12166	250	24	bronchodilator	bronchodilator	NOUN
ecj-12166	250	25	in	in	ADP
ecj-12166	250	26	pediatric	pediatric	ADJ
ecj-12166	250	27	patients	patient	NOUN
ecj-12166	250	28	with	with	ADP
ecj-12166	250	29	acute	acute	ADJ
ecj-12166	250	30	asthma	asthma	NOUN
ecj-12166	250	31	exacerbation	exacerbation	NOUN
ecj-12166	250	32	:	:	PUNCT
ecj-12166	250	33	a	a	DET
ecj-12166	250	34	review	review	NOUN
ecj-12166	250	35	.	.	PUNCT
ecj-12166	251	1	cureus	cureus	PROPN
ecj-12166	251	2	2023;15	2023;15	NUM
ecj-12166	251	3	:	:	PUNCT
ecj-12166	251	4	e40789	e40789	PROPN
ecj-12166	251	5	.	.	NOUN
ecj-12166	251	6	56	56	NUM
ecj-12166	251	7	.	.	PUNCT
ecj-12166	252	1	pardue	pardue	PROPN
ecj-12166	252	2	jones	jones	PROPN
ecj-12166	252	3	b	b	PROPN
ecj-12166	252	4	,	,	PUNCT
ecj-12166	252	5	fleming	fleming	PROPN
ecj-12166	252	6	gm	gm	PROPN
ecj-12166	252	7	,	,	PUNCT
ecj-12166	252	8	otillio	otillio	PROPN
ecj-12166	252	9	jk	jk	PROPN
ecj-12166	252	10	,	,	PUNCT
ecj-12166	252	11	et	et	PROPN
ecj-12166	252	12	al	al	PROPN
ecj-12166	252	13	.	.	PROPN
ecj-12166	252	14	pediatric	pediatric	ADJ
ecj-12166	252	15	acute	acute	PROPN
ecj-12166	252	16	asthma	asthma	NOUN
ecj-12166	252	17	exacerbations	exacerbation	NOUN
ecj-12166	252	18	:	:	PUNCT
ecj-12166	252	19	evaluation	evaluation	NOUN
ecj-12166	252	20	and	and	CCONJ
ecj-12166	252	21	management	management	NOUN
ecj-12166	252	22	from	from	ADP
ecj-12166	252	23	emergency	emergency	NOUN
ecj-12166	252	24	department	department	NOUN
ecj-12166	252	25	to	to	ADP
ecj-12166	252	26	intensive	intensive	ADJ
ecj-12166	252	27	care	care	NOUN
ecj-12166	252	28	unit	unit	NOUN
ecj-12166	252	29	.	.	PUNCT
ecj-12166	253	1	j	j	PROPN
ecj-12166	253	2	asthma	asthma	PROPN
ecj-12166	253	3	2016;53	2016;53	NUM
ecj-12166	253	4	:	:	PUNCT
ecj-12166	253	5	607	607	NUM
ecj-12166	253	6	-	-	SYM
ecj-12166	253	7	17	17	NUM
ecj-12166	253	8	.	.	PUNCT
ecj-12166	253	9	57	57	NUM
ecj-12166	253	10	.	.	PUNCT
ecj-12166	254	1	garner	garner	NOUN
ecj-12166	254	2	o	o	PROPN
ecj-12166	254	3	,	,	PUNCT
ecj-12166	254	4	ramey	ramey	PROPN
ecj-12166	254	5	js	js	PROPN
ecj-12166	254	6	,	,	PUNCT
ecj-12166	254	7	hanania	hanania	PROPN
ecj-12166	254	8	na	na	PROPN
ecj-12166	254	9	.	.	PUNCT
ecj-12166	254	10	management	management	NOUN
ecj-12166	254	11	of	of	ADP
ecj-12166	254	12	lifethreatening	lifethreatene	VERB
ecj-12166	254	13	asthma	asthma	NOUN
ecj-12166	254	14	:	:	PUNCT
ecj-12166	254	15	severe	severe	ADJ
ecj-12166	254	16	asthma	asthma	PROPN
ecj-12166	254	17	series	series	PROPN
ecj-12166	254	18	.	.	PUNCT
ecj-12166	255	1	chest	chest	PROPN
ecj-12166	255	2	2022;162:747	2022;162:747	NUM
ecj-12166	255	3	-	-	SYM
ecj-12166	255	4	56	56	NUM
ecj-12166	255	5	.	.	PUNCT
ecj-12166	255	6	58	58	NUM
ecj-12166	255	7	.	.	PUNCT
ecj-12166	256	1	alkhachroum	alkhachroum	PROPN
ecj-12166	256	2	a	a	DET
ecj-12166	256	3	,	,	PUNCT
ecj-12166	256	4	der	der	NOUN
ecj-12166	256	5	-	-	PUNCT
ecj-12166	256	6	nigoghossian	nigoghossian	NOUN
ecj-12166	256	7	ca	ca	NOUN
ecj-12166	256	8	,	,	PUNCT
ecj-12166	256	9	mathews	mathews	PROPN
ecj-12166	256	10	e	e	PROPN
ecj-12166	256	11	,	,	PUNCT
ecj-12166	256	12	et	et	PROPN
ecj-12166	256	13	al	al	PROPN
ecj-12166	256	14	.	.	PROPN
ecj-12166	256	15	ketamine	ketamine	PROPN
ecj-12166	256	16	to	to	PART
ecj-12166	256	17	treat	treat	VERB
ecj-12166	256	18	super	super	ADJ
ecj-12166	256	19	-	-	ADJ
ecj-12166	256	20	refractory	refractory	ADJ
ecj-12166	256	21	status	status	NOUN
ecj-12166	256	22	epilepticus	epilepticus	VERB
ecj-12166	256	23	.	.	PUNCT
ecj-12166	257	1	neurology	neurology	NOUN
ecj-12166	257	2	2020;95	2020;95	NUM
ecj-12166	257	3	:	:	PUNCT
ecj-12166	257	4	e2286	e2286	PROPN
ecj-12166	257	5	-	-	SYM
ecj-12166	257	6	94	94	NUM
ecj-12166	257	7	.	.	PUNCT
ecj-12166	258	1	59	59	NUM
ecj-12166	258	2	.	.	X
ecj-12166	259	1	lahti	lahti	PROPN
ecj-12166	259	2	ac	ac	PROPN
ecj-12166	259	3	,	,	PUNCT
ecj-12166	259	4	weiler	weiler	PROPN
ecj-12166	259	5	ma	ma	PROPN
ecj-12166	259	6	,	,	PUNCT
ecj-12166	259	7	tamara	tamara	PROPN
ecj-12166	259	8	michaelidis	michaelidis	PROPN
ecj-12166	259	9	ba	ba	PROPN
ecj-12166	259	10	,	,	PUNCT
ecj-12166	259	11	et	et	PROPN
ecj-12166	259	12	al	al	PROPN
ecj-12166	259	13	.	.	PUNCT
ecj-12166	259	14	effects	effect	NOUN
ecj-12166	259	15	of	of	ADP
ecj-12166	259	16	ketamine	ketamine	PROPN
ecj-12166	259	17	in	in	ADP
ecj-12166	259	18	normal	normal	ADJ
ecj-12166	259	19	and	and	CCONJ
ecj-12166	259	20	schizophrenic	schizophrenic	ADJ
ecj-12166	259	21	volunteers	volunteer	NOUN
ecj-12166	259	22	.	.	PUNCT
ecj-12166	260	1	neuropsychopharmacology	neuropsychopharmacology	PROPN
ecj-12166	260	2	2001;25:455	2001;25:455	PROPN
ecj-12166	260	3	-	-	PUNCT
ecj-12166	260	4	67	67	NUM
ecj-12166	260	5	.	.	PUNCT
ecj-12166	260	6	60	60	NUM
ecj-12166	260	7	.	.	PUNCT
ecj-12166	261	1	coppel	coppel	PROPN
ecj-12166	261	2	dl	dl	PROPN
ecj-12166	261	3	,	,	PUNCT
ecj-12166	261	4	bovill	bovill	PROPN
ecj-12166	261	5	jg	jg	PROPN
ecj-12166	261	6	,	,	PUNCT
ecj-12166	261	7	dundee	dundee	PROPN
ecj-12166	261	8	jw	jw	PROPN
ecj-12166	261	9	.	.	PUNCT
ecj-12166	262	1	the	the	DET
ecj-12166	262	2	taming	taming	NOUN
ecj-12166	262	3	of	of	ADP
ecj-12166	262	4	ketamine	ketamine	NOUN
ecj-12166	262	5	.	.	PUNCT
ecj-12166	263	1	anaesthesia	anaesthesia	PROPN
ecj-12166	263	2	1973;28:293	1973;28:293	NUM
ecj-12166	263	3	-	-	SYM
ecj-12166	263	4	6	6	NUM
ecj-12166	263	5	.	.	NOUN
ecj-12166	263	6	61	61	NUM
ecj-12166	263	7	.	.	PUNCT
ecj-12166	264	1	schep	schep	PROPN
ecj-12166	264	2	lj	lj	PROPN
ecj-12166	264	3	,	,	PUNCT
ecj-12166	264	4	slaughter	slaughter	PROPN
ecj-12166	264	5	rj	rj	PROPN
ecj-12166	264	6	,	,	PUNCT
ecj-12166	264	7	watts	watts	PROPN
ecj-12166	264	8	m	m	PROPN
ecj-12166	264	9	,	,	PUNCT
ecj-12166	264	10	mackenzie	mackenzie	NOUN
ecj-12166	264	11	e	e	PROPN
ecj-12166	264	12	,	,	PUNCT
ecj-12166	264	13	gee	gee	INTJ
ecj-12166	265	1	p.	p.	NOUN
ecj-12166	265	2	the	the	DET
ecj-12166	265	3	clinical	clinical	ADJ
ecj-12166	265	4	toxicology	toxicology	NOUN
ecj-12166	265	5	of	of	ADP
ecj-12166	265	6	ketamine	ketamine	PROPN
ecj-12166	265	7	.	.	PUNCT
ecj-12166	266	1	clin	clin	PROPN
ecj-12166	266	2	toxicol	toxicol	PROPN
ecj-12166	266	3	(	(	PUNCT
ecj-12166	266	4	phila	phila	PROPN
ecj-12166	266	5	)	)	PUNCT
ecj-12166	267	1	2023;61:415	2023;61:415	NUM
ecj-12166	267	2	-	-	SYM
ecj-12166	267	3	28	28	NUM
ecj-12166	267	4	.	.	PUNCT
ecj-12166	268	1	62	62	NUM
ecj-12166	268	2	.	.	PUNCT
ecj-12166	269	1	bellolio	bellolio	NOUN
ecj-12166	269	2	mf	mf	PROPN
ecj-12166	269	3	,	,	PUNCT
ecj-12166	269	4	gilani	gilani	PROPN
ecj-12166	269	5	wi	wi	PROPN
ecj-12166	269	6	,	,	PUNCT
ecj-12166	269	7	barrionuevo	barrionuevo	VERB
ecj-12166	269	8	p	p	PRON
ecj-12166	269	9	,	,	PUNCT
ecj-12166	269	10	et	et	PROPN
ecj-12166	269	11	al	al	PROPN
ecj-12166	269	12	.	.	PROPN
ecj-12166	269	13	incidence	incidence	NOUN
ecj-12166	269	14	of	of	ADP
ecj-12166	269	15	adverse	adverse	ADJ
ecj-12166	269	16	events	event	NOUN
ecj-12166	269	17	in	in	ADP
ecj-12166	269	18	adults	adult	NOUN
ecj-12166	269	19	undergoing	undergo	VERB
ecj-12166	269	20	procedural	procedural	ADJ
ecj-12166	269	21	sedation	sedation	NOUN
ecj-12166	269	22	in	in	ADP
ecj-12166	269	23	the	the	DET
ecj-12166	269	24	emergency	emergency	NOUN
ecj-12166	269	25	department	department	NOUN
ecj-12166	269	26	:	:	PUNCT
ecj-12166	269	27	a	a	DET
ecj-12166	269	28	systematic	systematic	ADJ
ecj-12166	269	29	review	review	NOUN
ecj-12166	269	30	and	and	CCONJ
ecj-12166	269	31	metaanalysis	metaanalysis	NOUN
ecj-12166	269	32	.	.	PUNCT
ecj-12166	270	1	acad	acad	PROPN
ecj-12166	270	2	emerg	emerg	PROPN
ecj-12166	270	3	med	med	ADJ
ecj-12166	270	4	2016;23:119	2016;23:119	PROPN
ecj-12166	270	5	-	-	SYM
ecj-12166	270	6	34	34	NUM
ecj-12166	270	7	.	.	PUNCT
ecj-12166	270	8	63	63	NUM
ecj-12166	270	9	.	.	PUNCT
ecj-12166	270	10	green	green	PROPN
ecj-12166	270	11	sm	sm	PROPN
ecj-12166	270	12	,	,	PUNCT
ecj-12166	270	13	roback	roback	VERB
ecj-12166	270	14	mg	mg	PROPN
ecj-12166	270	15	,	,	PUNCT
ecj-12166	270	16	krauss	krauss	PROPN
ecj-12166	270	17	b	b	PROPN
ecj-12166	270	18	,	,	PUNCT
ecj-12166	270	19	emergency	emergency	PROPN
ecj-12166	270	20	department	department	NOUN
ecj-12166	270	21	ketamine	ketamine	PROPN
ecj-12166	270	22	meta	meta	ADJ
ecj-12166	270	23	-	-	PUNCT
ecj-12166	270	24	analysis	analysis	NOUN
ecj-12166	270	25	study	study	NOUN
ecj-12166	270	26	group	group	NOUN
ecj-12166	270	27	.	.	PUNCT
ecj-12166	271	1	laryngospasm	laryngospasm	PROPN
ecj-12166	271	2	during	during	ADP
ecj-12166	271	3	emergency	emergency	PROPN
ecj-12166	271	4	department	department	PROPN
ecj-12166	271	5	ketamine	ketamine	PROPN
ecj-12166	271	6	sedation	sedation	NOUN
ecj-12166	271	7	:	:	PUNCT
ecj-12166	271	8	a	a	DET
ecj-12166	271	9	case	case	NOUN
ecj-12166	271	10	-	-	PUNCT
ecj-12166	271	11	control	control	NOUN
ecj-12166	271	12	study	study	NOUN
ecj-12166	271	13	.	.	PUNCT
ecj-12166	272	1	pediatr	pediatr	PROPN
ecj-12166	272	2	emerg	emerg	PROPN
ecj-12166	272	3	care	care	NOUN
ecj-12166	272	4	2010;26:798	2010;26:798	NOUN
ecj-12166	272	5	-	-	SYM
ecj-12166	272	6	802	802	NUM
ecj-12166	272	7	.	.	PUNCT
ecj-12166	272	8	64	64	NUM
ecj-12166	272	9	.	.	PUNCT
ecj-12166	273	1	morgan	morgan	PROPN
ecj-12166	273	2	mw	mw	PROPN
ecj-12166	273	3	,	,	PUNCT
ecj-12166	273	4	dore	dore	PROPN
ecj-12166	273	5	e.	e.	PROPN
ecj-12166	273	6	a	a	DET
ecj-12166	273	7	case	case	NOUN
ecj-12166	273	8	report	report	NOUN
ecj-12166	273	9	of	of	ADP
ecj-12166	273	10	opisthotonos	opisthotonos	PROPN
ecj-12166	273	11	associated	associate	VERB
ecj-12166	273	12	with	with	ADP
ecj-12166	273	13	administration	administration	NOUN
ecj-12166	273	14	of	of	ADP
ecj-12166	273	15	intramuscular	intramuscular	ADJ
ecj-12166	273	16	ketamine	ketamine	PROPN
ecj-12166	273	17	.	.	PUNCT
ecj-12166	274	1	clin	clin	PROPN
ecj-12166	274	2	pract	pract	PROPN
ecj-12166	274	3	cases	case	NOUN
ecj-12166	274	4	emerg	emerg	VERB
ecj-12166	274	5	med	med	ADJ
ecj-12166	274	6	2021;5:429	2021;5:429	PROPN
ecj-12166	274	7	-	-	SYM
ecj-12166	274	8	31	31	NUM
ecj-12166	274	9	.	.	PUNCT
ecj-12166	275	1	65	65	NUM
ecj-12166	275	2	.	.	PUNCT
ecj-12166	276	1	strayer	strayer	PROPN
ecj-12166	276	2	rj	rj	PROPN
ecj-12166	276	3	,	,	PUNCT
ecj-12166	276	4	nelson	nelson	PROPN
ecj-12166	276	5	ls	ls	PROPN
ecj-12166	276	6	.	.	PROPN
ecj-12166	277	1	adverse	adverse	ADJ
ecj-12166	277	2	events	event	NOUN
ecj-12166	277	3	associated	associate	VERB
ecj-12166	277	4	with	with	ADP
ecj-12166	277	5	ketamine	ketamine	PROPN
ecj-12166	277	6	for	for	ADP
ecj-12166	277	7	procedural	procedural	ADJ
ecj-12166	277	8	sedation	sedation	NOUN
ecj-12166	277	9	in	in	ADP
ecj-12166	277	10	adults	adult	NOUN
ecj-12166	277	11	.	.	PUNCT
ecj-12166	278	1	am	be	AUX
ecj-12166	278	2	j	j	PROPN
ecj-12166	278	3	emerg	emerg	PROPN
ecj-12166	278	4	med	med	ADJ
ecj-12166	278	5	2008;26:985	2008;26:985	NOUN
ecj-12166	278	6	-	-	SYM
ecj-12166	278	7	1028	1028	NUM
ecj-12166	278	8	.	.	PUNCT
ecj-12166	279	1	66	66	NUM
ecj-12166	279	2	.	.	PUNCT
ecj-12166	280	1	maneglia	maneglia	PROPN
ecj-12166	280	2	r	r	PROPN
ecj-12166	280	3	,	,	PUNCT
ecj-12166	280	4	cousin	cousin	PROPN
ecj-12166	280	5	mt	mt	PROPN
ecj-12166	280	6	.	.	PROPN
ecj-12166	281	1	a	a	DET
ecj-12166	281	2	comparison	comparison	NOUN
ecj-12166	281	3	between	between	ADP
ecj-12166	281	4	propofol	propofol	NOUN
ecj-12166	281	5	and	and	CCONJ
ecj-12166	281	6	ketamine	ketamine	NOUN
ecj-12166	281	7	for	for	ADP
ecj-12166	281	8	anaesthesia	anaesthesia	NOUN
ecj-12166	281	9	in	in	ADP
ecj-12166	281	10	the	the	DET
ecj-12166	281	11	elderly	elderly	ADJ
ecj-12166	281	12	.	.	PUNCT
ecj-12166	282	1	haemodynamic	haemodynamic	ADJ
ecj-12166	282	2	effects	effect	NOUN
ecj-12166	282	3	during	during	ADP
ecj-12166	282	4	induction	induction	NOUN
ecj-12166	282	5	and	and	CCONJ
ecj-12166	282	6	maintenance	maintenance	NOUN
ecj-12166	282	7	.	.	PUNCT
ecj-12166	283	1	anaesthesia	anaesthesia	PROPN
ecj-12166	284	1	1988;43:10911	1988;43:10911	NUM
ecj-12166	284	2	.	.	PROPN
ecj-12166	285	1	67	67	NUM
ecj-12166	285	2	.	.	PUNCT
ecj-12166	286	1	kanbak	kanbak	PROPN
ecj-12166	286	2	m.	m.	PROPN
ecj-12166	286	3	ketamine	ketamine	PROPN
ecj-12166	286	4	in	in	ADP
ecj-12166	286	5	porphyria	porphyria	PROPN
ecj-12166	286	6	.	.	PUNCT
ecj-12166	287	1	anesth	anesth	PROPN
ecj-12166	287	2	analg	analg	PROPN
ecj-12166	287	3	1997;84:1395	1997;84:1395	NUM
ecj-12166	287	4	.	.	PUNCT
ecj-12166	287	5	mini	mini	ADJ
ecj-12166	287	6	review	review	NOUN
ecj-12166	287	7	[	[	X
ecj-12166	287	8	emergency	emergency	NOUN
ecj-12166	287	9	care	care	NOUN
ecj-12166	287	10	journal	journal	PROPN
ecj-12166	287	11	2024	2024	NUM
ecj-12166	287	12	;	;	PUNCT
ecj-12166	287	13	20:12166	20:12166	NUM
ecj-12166	287	14	]	]	X
ecj-12166	288	1	[	[	X
ecj-12166	288	2	page	page	NOUN
ecj-12166	288	3	35	35	NUM
ecj-12166	288	4	]	]	PUNCT
ecj-12166	288	5	non	non	ADJ
ecj-12166	288	6	-co	-co	PROPN
ecj-12166	288	7	mmerc	mmerc	PROPN
ecj-12166	288	8	ial	ial	PROPN
ecj-12166	288	9	us	us	PROPN
ecj-12166	288	10	e	e	NOUN
ecj-12166	288	11	o	o	NOUN
ecj-12166	288	12	nly	nly	ADV