id	sid	tid	token	lemma	pos
ecj-12310	1	1	hrev_master	hrev_master	NOUN
ecj-12310	2	1	[	[	X
ecj-12310	2	2	page	page	NOUN
ecj-12310	2	3	31	31	NUM
ecj-12310	2	4	]	]	PUNCT
ecj-12310	3	1	[	[	X
ecj-12310	3	2	emergency	emergency	NOUN
ecj-12310	3	3	care	care	NOUN
ecj-12310	3	4	journal	journal	PROPN
ecj-12310	3	5	2024	2024	NUM
ecj-12310	3	6	;	;	PUNCT
ecj-12310	3	7	20:12310	20:12310	NUM
ecj-12310	3	8	]	]	X
ecj-12310	3	9	emergency	emergency	NOUN
ecj-12310	3	10	care	care	NOUN
ecj-12310	3	11	journal	journal	PROPN
ecj-12310	3	12	2024	2024	NUM
ecj-12310	3	13	volume	volume	NOUN
ecj-12310	3	14	20:12310	20:12310	NUM
ecj-12310	3	15	abstract	abstract	NOUN
ecj-12310	3	16	in	in	ADP
ecj-12310	3	17	the	the	DET
ecj-12310	3	18	management	management	NOUN
ecj-12310	3	19	of	of	ADP
ecj-12310	3	20	severe	severe	ADJ
ecj-12310	3	21	traumatic	traumatic	ADJ
ecj-12310	3	22	brain	brain	NOUN
ecj-12310	3	23	injuries	injury	NOUN
ecj-12310	3	24	(	(	PUNCT
ecj-12310	3	25	tbis	tbis	PROPN
ecj-12310	3	26	)	)	PUNCT
ecj-12310	3	27	,	,	PUNCT
ecj-12310	3	28	controlling	control	VERB
ecj-12310	3	29	intracranial	intracranial	ADJ
ecj-12310	3	30	pressure	pressure	NOUN
ecj-12310	3	31	(	(	PUNCT
ecj-12310	3	32	icp	icp	PROPN
ecj-12310	3	33	)	)	PUNCT
ecj-12310	3	34	is	be	AUX
ecj-12310	3	35	a	a	DET
ecj-12310	3	36	pivotal	pivotal	ADJ
ecj-12310	3	37	therapeutic	therapeutic	ADJ
ecj-12310	3	38	goal	goal	NOUN
ecj-12310	3	39	.	.	PUNCT
ecj-12310	4	1	historically	historically	ADV
ecj-12310	4	2	,	,	PUNCT
ecj-12310	4	3	mannitol	mannitol	NOUN
ecj-12310	4	4	has	have	AUX
ecj-12310	4	5	been	be	AUX
ecj-12310	4	6	the	the	DET
ecj-12310	4	7	recommended	recommend	VERB
ecj-12310	4	8	first	first	ADJ
ecj-12310	4	9	-	-	PUNCT
ecj-12310	4	10	line	line	NOUN
ecj-12310	4	11	osmotic	osmotic	ADJ
ecj-12310	4	12	agent	agent	NOUN
ecj-12310	4	13	;	;	PUNCT
ecj-12310	4	14	however	however	ADV
ecj-12310	4	15	,	,	PUNCT
ecj-12310	4	16	concerns	concern	NOUN
ecj-12310	4	17	surrounding	surround	VERB
ecj-12310	4	18	its	its	PRON
ecj-12310	4	19	use	use	NOUN
ecj-12310	4	20	,	,	PUNCT
ecj-12310	4	21	including	include	VERB
ecj-12310	4	22	hypotension	hypotension	NOUN
ecj-12310	4	23	,	,	PUNCT
ecj-12310	4	24	rebound	rebound	VERB
ecj-12310	4	25	icp	icp	PROPN
ecj-12310	4	26	elevation	elevation	NOUN
ecj-12310	4	27	,	,	PUNCT
ecj-12310	4	28	and	and	CCONJ
ecj-12310	4	29	renal	renal	ADJ
ecj-12310	4	30	toxicity	toxicity	NOUN
ecj-12310	4	31	,	,	PUNCT
ecj-12310	4	32	have	have	AUX
ecj-12310	4	33	prompted	prompt	VERB
ecj-12310	4	34	a	a	DET
ecj-12310	4	35	quest	quest	NOUN
ecj-12310	4	36	for	for	ADP
ecj-12310	4	37	alternative	alternative	ADJ
ecj-12310	4	38	strategies	strategy	NOUN
ecj-12310	4	39	.	.	PUNCT
ecj-12310	5	1	hypertonic	hypertonic	ADJ
ecj-12310	5	2	saline	saline	NOUN
ecj-12310	5	3	(	(	PUNCT
ecj-12310	5	4	hs	hs	X
ecj-12310	5	5	)	)	PUNCT
ecj-12310	5	6	has	have	AUX
ecj-12310	5	7	emerged	emerge	VERB
ecj-12310	5	8	as	as	ADP
ecj-12310	5	9	a	a	DET
ecj-12310	5	10	promising	promising	ADJ
ecj-12310	5	11	substitute	substitute	NOUN
ecj-12310	5	12	,	,	PUNCT
ecj-12310	5	13	demonstrating	demonstrate	VERB
ecj-12310	5	14	efficacy	efficacy	NOUN
ecj-12310	5	15	in	in	ADP
ecj-12310	5	16	reducing	reduce	VERB
ecj-12310	5	17	icp	icp	PROPN
ecj-12310	5	18	without	without	ADP
ecj-12310	5	19	compromising	compromise	VERB
ecj-12310	5	20	cerebral	cerebral	ADJ
ecj-12310	5	21	perfusion	perfusion	NOUN
ecj-12310	5	22	.	.	PUNCT
ecj-12310	6	1	this	this	DET
ecj-12310	6	2	comprehensive	comprehensive	ADJ
ecj-12310	6	3	analysis	analysis	NOUN
ecj-12310	6	4	explores	explore	VERB
ecj-12310	6	5	the	the	DET
ecj-12310	6	6	comparative	comparative	ADJ
ecj-12310	6	7	effectiveness	effectiveness	NOUN
ecj-12310	6	8	of	of	ADP
ecj-12310	6	9	mannitol	mannitol	NOUN
ecj-12310	6	10	and	and	CCONJ
ecj-12310	6	11	hypertonic	hypertonic	ADJ
ecj-12310	6	12	saline	saline	NOUN
ecj-12310	6	13	in	in	ADP
ecj-12310	6	14	the	the	DET
ecj-12310	6	15	context	context	NOUN
ecj-12310	6	16	of	of	ADP
ecj-12310	6	17	severe	severe	ADJ
ecj-12310	6	18	tbis	tbi	NOUN
ecj-12310	6	19	.	.	PUNCT
ecj-12310	7	1	while	while	SCONJ
ecj-12310	7	2	mannitol	mannitol	NOUN
ecj-12310	7	3	has	have	AUX
ecj-12310	7	4	been	be	AUX
ecj-12310	7	5	a	a	DET
ecj-12310	7	6	longstanding	longstanding	ADJ
ecj-12310	7	7	choice	choice	NOUN
ecj-12310	7	8	,	,	PUNCT
ecj-12310	7	9	recent	recent	ADJ
ecj-12310	7	10	attention	attention	NOUN
ecj-12310	7	11	has	have	AUX
ecj-12310	7	12	shifted	shift	VERB
ecj-12310	7	13	towards	towards	ADP
ecj-12310	7	14	hs	hs	PROPN
ecj-12310	7	15	due	due	ADP
ecj-12310	7	16	to	to	ADP
ecj-12310	7	17	its	its	PRON
ecj-12310	7	18	reported	report	VERB
ecj-12310	7	19	superiority	superiority	NOUN
ecj-12310	7	20	in	in	ADP
ecj-12310	7	21	icp	icp	PROPN
ecj-12310	7	22	reduction	reduction	NOUN
ecj-12310	7	23	.	.	PUNCT
ecj-12310	8	1	concerns	concern	NOUN
ecj-12310	8	2	associated	associate	VERB
ecj-12310	8	3	with	with	ADP
ecj-12310	8	4	mannitol	mannitol	NOUN
ecj-12310	8	5	,	,	PUNCT
ecj-12310	8	6	such	such	ADJ
ecj-12310	8	7	as	as	ADP
ecj-12310	8	8	hypotension	hypotension	NOUN
ecj-12310	8	9	and	and	CCONJ
ecj-12310	8	10	rebound	rebound	VERB
ecj-12310	8	11	icp	icp	PROPN
ecj-12310	8	12	,	,	PUNCT
ecj-12310	8	13	are	be	AUX
ecj-12310	8	14	juxtaposed	juxtapose	VERB
ecj-12310	8	15	against	against	ADP
ecj-12310	8	16	the	the	DET
ecj-12310	8	17	potential	potential	ADJ
ecj-12310	8	18	advantages	advantage	NOUN
ecj-12310	8	19	offered	offer	VERB
ecj-12310	8	20	by	by	ADP
ecj-12310	8	21	hs	hs	PROPN
ecj-12310	8	22	.	.	PUNCT
ecj-12310	9	1	the	the	DET
ecj-12310	9	2	scarcity	scarcity	NOUN
ecj-12310	9	3	of	of	ADP
ecj-12310	9	4	clinical	clinical	ADJ
ecj-12310	9	5	studies	study	NOUN
ecj-12310	9	6	focusing	focus	VERB
ecj-12310	9	7	on	on	ADP
ecj-12310	9	8	tbirelated	tbirelate	VERB
ecj-12310	9	9	outcomes	outcome	NOUN
ecj-12310	9	10	,	,	PUNCT
ecj-12310	9	11	such	such	ADJ
ecj-12310	9	12	as	as	ADP
ecj-12310	9	13	patient	patient	ADJ
ecj-12310	9	14	survival	survival	NOUN
ecj-12310	9	15	and	and	CCONJ
ecj-12310	9	16	long	long	ADJ
ecj-12310	9	17	-	-	PUNCT
ecj-12310	9	18	term	term	NOUN
ecj-12310	9	19	benefits	benefit	NOUN
ecj-12310	9	20	,	,	PUNCT
ecj-12310	9	21	is	be	AUX
ecj-12310	9	22	highlighted	highlight	VERB
ecj-12310	9	23	,	,	PUNCT
ecj-12310	9	24	underscoring	underscore	VERB
ecj-12310	9	25	a	a	DET
ecj-12310	9	26	critical	critical	ADJ
ecj-12310	9	27	gap	gap	NOUN
ecj-12310	9	28	in	in	ADP
ecj-12310	9	29	the	the	DET
ecj-12310	9	30	current	current	ADJ
ecj-12310	9	31	knowledge	knowledge	NOUN
ecj-12310	9	32	landscape	landscape	NOUN
ecj-12310	9	33	.	.	PUNCT
ecj-12310	10	1	the	the	DET
ecj-12310	10	2	review	review	NOUN
ecj-12310	10	3	aims	aim	VERB
ecj-12310	10	4	to	to	PART
ecj-12310	10	5	provide	provide	VERB
ecj-12310	10	6	a	a	DET
ecj-12310	10	7	nuanced	nuanced	ADJ
ecj-12310	10	8	understanding	understanding	NOUN
ecj-12310	10	9	of	of	ADP
ecj-12310	10	10	the	the	DET
ecj-12310	10	11	comparative	comparative	ADJ
ecj-12310	10	12	effectiveness	effectiveness	NOUN
ecj-12310	10	13	of	of	ADP
ecj-12310	10	14	mannitol	mannitol	NOUN
ecj-12310	10	15	and	and	CCONJ
ecj-12310	10	16	hypertonic	hypertonic	ADJ
ecj-12310	10	17	saline	saline	NOUN
ecj-12310	10	18	,	,	PUNCT
ecj-12310	10	19	considering	consider	VERB
ecj-12310	10	20	not	not	PART
ecj-12310	10	21	only	only	ADV
ecj-12310	10	22	icp	icp	PROPN
ecj-12310	10	23	control	control	NOUN
ecj-12310	10	24	but	but	CCONJ
ecj-12310	10	25	also	also	ADV
ecj-12310	10	26	broader	broad	ADJ
ecj-12310	10	27	patient	patient	ADJ
ecj-12310	10	28	outcomes	outcome	NOUN
ecj-12310	10	29	.	.	PUNCT
ecj-12310	11	1	by	by	ADP
ecj-12310	11	2	addressing	address	VERB
ecj-12310	11	3	the	the	DET
ecj-12310	11	4	suitability	suitability	NOUN
ecj-12310	11	5	of	of	ADP
ecj-12310	11	6	these	these	DET
ecj-12310	11	7	agents	agent	NOUN
ecj-12310	11	8	in	in	ADP
ecj-12310	11	9	diverse	diverse	ADJ
ecj-12310	11	10	clinical	clinical	ADJ
ecj-12310	11	11	settings	setting	NOUN
ecj-12310	11	12	,	,	PUNCT
ecj-12310	11	13	this	this	DET
ecj-12310	11	14	analysis	analysis	NOUN
ecj-12310	11	15	seeks	seek	VERB
ecj-12310	11	16	to	to	PART
ecj-12310	11	17	guide	guide	VERB
ecj-12310	11	18	clinicians	clinician	NOUN
ecj-12310	11	19	in	in	ADP
ecj-12310	11	20	making	make	VERB
ecj-12310	11	21	informed	informed	ADJ
ecj-12310	11	22	decisions	decision	NOUN
ecj-12310	11	23	tailored	tailor	VERB
ecj-12310	11	24	to	to	ADP
ecj-12310	11	25	individual	individual	ADJ
ecj-12310	11	26	patient	patient	NOUN
ecj-12310	11	27	needs	need	NOUN
ecj-12310	11	28	.	.	PUNCT
ecj-12310	12	1	introduction	introduction	NOUN
ecj-12310	12	2	traumatic	traumatic	ADJ
ecj-12310	12	3	brain	brain	NOUN
ecj-12310	12	4	injury	injury	NOUN
ecj-12310	12	5	(	(	PUNCT
ecj-12310	12	6	tbi	tbi	NOUN
ecj-12310	12	7	)	)	PUNCT
ecj-12310	12	8	is	be	AUX
ecj-12310	12	9	on	on	ADP
ecj-12310	12	10	the	the	DET
ecj-12310	12	11	rise	rise	NOUN
ecj-12310	12	12	as	as	ADP
ecj-12310	12	13	a	a	DET
ecj-12310	12	14	leading	lead	VERB
ecj-12310	12	15	cause	cause	NOUN
ecj-12310	12	16	of	of	ADP
ecj-12310	12	17	death	death	NOUN
ecj-12310	12	18	and	and	CCONJ
ecj-12310	12	19	an	an	DET
ecj-12310	12	20	important	important	ADJ
ecj-12310	12	21	contributor	contributor	NOUN
ecj-12310	12	22	to	to	ADP
ecj-12310	12	23	morbidity	morbidity	NOUN
ecj-12310	12	24	and	and	CCONJ
ecj-12310	12	25	mortality	mortality	NOUN
ecj-12310	12	26	.	.	PUNCT
ecj-12310	13	1	as	as	SCONJ
ecj-12310	13	2	seen	see	VERB
ecj-12310	13	3	by	by	ADP
ecj-12310	13	4	declining	decline	VERB
ecj-12310	13	5	mortality	mortality	NOUN
ecj-12310	13	6	rates	rate	NOUN
ecj-12310	13	7	,	,	PUNCT
ecj-12310	13	8	medical	medical	ADJ
ecj-12310	13	9	treatment	treatment	NOUN
ecj-12310	13	10	for	for	ADP
ecj-12310	13	11	severe	severe	ADJ
ecj-12310	13	12	tbi	tbi	PROPN
ecj-12310	13	13	has	have	AUX
ecj-12310	13	14	advanced	advance	VERB
ecj-12310	13	15	significantly	significantly	ADV
ecj-12310	13	16	in	in	ADP
ecj-12310	13	17	recent	recent	ADJ
ecj-12310	13	18	years.1	years.1	NOUN
ecj-12310	13	19	the	the	DET
ecj-12310	13	20	“	"	PUNCT
ecj-12310	13	21	silent	silent	ADJ
ecj-12310	13	22	epidemic	epidemic	NOUN
ecj-12310	13	23	”	"	PUNCT
ecj-12310	13	24	of	of	ADP
ecj-12310	13	25	increased	increase	VERB
ecj-12310	13	26	icp	icp	PROPN
ecj-12310	13	27	is	be	AUX
ecj-12310	13	28	a	a	DET
ecj-12310	13	29	prevalent	prevalent	ADJ
ecj-12310	13	30	life	life	NOUN
ecj-12310	13	31	-	-	PUNCT
ecj-12310	13	32	threatening	threaten	VERB
ecj-12310	13	33	illness.2	illness.2	ADP
ecj-12310	13	34	most	most	ADJ
ecj-12310	13	35	neurological	neurological	ADJ
ecj-12310	13	36	ailments	ailment	NOUN
ecj-12310	13	37	principally	principally	ADV
ecj-12310	13	38	traumatic	traumatic	ADJ
ecj-12310	13	39	brain	brain	NOUN
ecj-12310	13	40	injury	injury	NOUN
ecj-12310	13	41	can	can	AUX
ecj-12310	13	42	cause	cause	VERB
ecj-12310	13	43	cerebral	cerebral	ADJ
ecj-12310	13	44	edema	edema	NOUN
ecj-12310	13	45	which	which	PRON
ecj-12310	13	46	eventually	eventually	ADV
ecj-12310	13	47	leads	lead	VERB
ecj-12310	13	48	to	to	ADP
ecj-12310	13	49	the	the	DET
ecj-12310	13	50	condition	condition	NOUN
ecj-12310	13	51	of	of	ADP
ecj-12310	13	52	increased	increase	VERB
ecj-12310	13	53	intracranial	intracranial	ADJ
ecj-12310	13	54	pressure	pressure	NOUN
ecj-12310	13	55	(	(	PUNCT
ecj-12310	13	56	icp	icp	PROPN
ecj-12310	13	57	)	)	PUNCT
ecj-12310	13	58	.	.	PUNCT
ecj-12310	14	1	the	the	DET
ecj-12310	14	2	main	main	ADJ
ecj-12310	14	3	factor	factor	NOUN
ecj-12310	14	4	that	that	PRON
ecj-12310	14	5	causes	cause	VERB
ecj-12310	14	6	death	death	NOUN
ecj-12310	14	7	in	in	ADP
ecj-12310	14	8	patients	patient	NOUN
ecj-12310	14	9	with	with	ADP
ecj-12310	14	10	acute	acute	ADJ
ecj-12310	14	11	cerebral	cerebral	ADJ
ecj-12310	14	12	edema	edema	NOUN
ecj-12310	14	13	is	be	AUX
ecj-12310	14	14	thought	think	VERB
ecj-12310	14	15	to	to	PART
ecj-12310	14	16	be	be	AUX
ecj-12310	14	17	elevated	elevate	VERB
ecj-12310	14	18	intracranial	intracranial	ADJ
ecj-12310	14	19	pressure	pressure	NOUN
ecj-12310	14	20	also	also	ADV
ecj-12310	14	21	known	know	VERB
ecj-12310	14	22	as	as	ADP
ecj-12310	14	23	intracranial	intracranial	ADJ
ecj-12310	14	24	hypertension	hypertension	NOUN
ecj-12310	14	25	(	(	PUNCT
ecj-12310	14	26	ih).3	ih).3	DET
ecj-12310	14	27	intracranial	intracranial	ADJ
ecj-12310	14	28	hypertension	hypertension	NOUN
ecj-12310	14	29	is	be	AUX
ecj-12310	14	30	one	one	NUM
ecj-12310	14	31	of	of	ADP
ecj-12310	14	32	the	the	DET
ecj-12310	14	33	commonly	commonly	ADV
ecj-12310	14	34	seen	see	VERB
ecj-12310	14	35	clinical	clinical	ADJ
ecj-12310	14	36	conditions	condition	NOUN
ecj-12310	14	37	in	in	ADP
ecj-12310	14	38	the	the	DET
ecj-12310	14	39	intensive	intensive	ADJ
ecj-12310	14	40	care	care	NOUN
ecj-12310	14	41	unit	unit	NOUN
ecj-12310	14	42	which	which	PRON
ecj-12310	14	43	requires	require	VERB
ecj-12310	14	44	instant	instant	ADJ
ecj-12310	14	45	treatment	treatment	NOUN
ecj-12310	14	46	.	.	PUNCT
ecj-12310	15	1	the	the	DET
ecj-12310	15	2	major	major	ADJ
ecj-12310	15	3	goal	goal	NOUN
ecj-12310	15	4	of	of	ADP
ecj-12310	15	5	care	care	NOUN
ecj-12310	15	6	is	be	AUX
ecj-12310	15	7	to	to	PART
ecj-12310	15	8	maintain	maintain	VERB
ecj-12310	15	9	normal	normal	ADJ
ecj-12310	15	10	cerebral	cerebral	ADJ
ecj-12310	15	11	perfusion	perfusion	NOUN
ecj-12310	15	12	pressure	pressure	NOUN
ecj-12310	15	13	and	and	CCONJ
ecj-12310	15	14	intracranial	intracranial	ADJ
ecj-12310	15	15	pressure	pressure	NOUN
ecj-12310	15	16	(	(	PUNCT
ecj-12310	15	17	icp	icp	NOUN
ecj-12310	15	18	)	)	PUNCT
ecj-12310	15	19	to	to	PART
ecj-12310	15	20	avoid	avoid	VERB
ecj-12310	15	21	secondary	secondary	ADJ
ecj-12310	15	22	brain	brain	NOUN
ecj-12310	15	23	injury.4	injury.4	NOUN
ecj-12310	15	24	ih	ih	PROPN
ecj-12310	15	25	is	be	AUX
ecj-12310	15	26	caused	cause	VERB
ecj-12310	15	27	by	by	ADP
ecj-12310	15	28	a	a	DET
ecj-12310	15	29	major	major	ADJ
ecj-12310	15	30	central	central	ADJ
ecj-12310	15	31	nervous	nervous	ADJ
ecj-12310	15	32	system	system	NOUN
ecj-12310	15	33	(	(	PUNCT
ecj-12310	15	34	cns	cns	NOUN
ecj-12310	15	35	)	)	PUNCT
ecj-12310	15	36	injury	injury	NOUN
ecj-12310	15	37	or	or	CCONJ
ecj-12310	15	38	a	a	DET
ecj-12310	15	39	side	side	ADJ
ecj-12310	15	40	effect	effect	NOUN
ecj-12310	15	41	of	of	ADP
ecj-12310	15	42	a	a	DET
ecj-12310	15	43	concurrent	concurrent	ADJ
ecj-12310	15	44	systemic	systemic	ADJ
ecj-12310	15	45	illness	illness	NOUN
ecj-12310	15	46	.	.	PUNCT
ecj-12310	16	1	acute	acute	ADJ
ecj-12310	16	2	brain	brain	NOUN
ecj-12310	16	3	injury	injury	NOUN
ecj-12310	16	4	(	(	PUNCT
ecj-12310	16	5	abi	abi	PROPN
ecj-12310	16	6	)	)	PUNCT
ecj-12310	16	7	,	,	PUNCT
ecj-12310	16	8	which	which	PRON
ecj-12310	16	9	is	be	AUX
ecj-12310	16	10	defined	define	VERB
ecj-12310	16	11	as	as	ADP
ecj-12310	16	12	any	any	DET
ecj-12310	16	13	condition	condition	NOUN
ecj-12310	16	14	affecting	affect	VERB
ecj-12310	16	15	the	the	DET
ecj-12310	16	16	central	central	ADJ
ecj-12310	16	17	nervous	nervous	ADJ
ecj-12310	16	18	system	system	NOUN
ecj-12310	16	19	,	,	PUNCT
ecj-12310	16	20	consists	consist	VERB
ecj-12310	16	21	of	of	ADP
ecj-12310	16	22	two	two	NUM
ecj-12310	16	23	parts	part	NOUN
ecj-12310	16	24	:	:	PUNCT
ecj-12310	16	25	a	a	DET
ecj-12310	16	26	primary	primary	ADJ
ecj-12310	16	27	brain	brain	NOUN
ecj-12310	16	28	damage	damage	NOUN
ecj-12310	16	29	that	that	PRON
ecj-12310	16	30	can	can	AUX
ecj-12310	16	31	not	not	PART
ecj-12310	16	32	be	be	AUX
ecj-12310	16	33	restored	restore	VERB
ecj-12310	16	34	and	and	CCONJ
ecj-12310	16	35	a	a	DET
ecj-12310	16	36	secondary	secondary	ADJ
ecj-12310	16	37	brain	brain	NOUN
ecj-12310	16	38	injury	injury	NOUN
ecj-12310	16	39	(	(	PUNCT
ecj-12310	16	40	sbi	sbi	PROPN
ecj-12310	16	41	)	)	PUNCT
ecj-12310	16	42	.	.	PUNCT
ecj-12310	17	1	any	any	DET
ecj-12310	17	2	physiological	physiological	ADJ
ecj-12310	17	3	occurrence	occurrence	NOUN
ecj-12310	17	4	that	that	PRON
ecj-12310	17	5	can	can	AUX
ecj-12310	17	6	happen	happen	VERB
ecj-12310	17	7	minutes	minute	NOUN
ecj-12310	17	8	,	,	PUNCT
ecj-12310	17	9	hours	hour	NOUN
ecj-12310	17	10	,	,	PUNCT
ecj-12310	17	11	or	or	CCONJ
ecj-12310	17	12	days	day	NOUN
ecj-12310	17	13	after	after	ADP
ecj-12310	17	14	the	the	DET
ecj-12310	17	15	initial	initial	ADJ
ecj-12310	17	16	insult	insult	NOUN
ecj-12310	17	17	and	and	CCONJ
ecj-12310	17	18	causes	cause	VERB
ecj-12310	17	19	additional	additional	ADJ
ecj-12310	17	20	nerve	nerve	NOUN
ecj-12310	17	21	damage	damage	NOUN
ecj-12310	17	22	is	be	AUX
ecj-12310	17	23	referred	refer	VERB
ecj-12310	17	24	to	to	ADP
ecj-12310	17	25	as	as	ADP
ecj-12310	17	26	a	a	DET
ecj-12310	17	27	sbi	sbi	NOUN
ecj-12310	17	28	.	.	PUNCT
ecj-12310	18	1	since	since	SCONJ
ecj-12310	18	2	it	it	PRON
ecj-12310	18	3	is	be	AUX
ecj-12310	18	4	primarily	primarily	ADV
ecj-12310	18	5	caused	cause	VERB
ecj-12310	18	6	by	by	ADP
ecj-12310	18	7	elevated	elevated	ADJ
ecj-12310	18	8	icp	icp	PROPN
ecj-12310	18	9	,	,	PUNCT
ecj-12310	18	10	it	it	PRON
ecj-12310	18	11	can	can	AUX
ecj-12310	18	12	be	be	AUX
ecj-12310	18	13	identified	identify	VERB
ecj-12310	18	14	through	through	ADP
ecj-12310	18	15	medical	medical	ADJ
ecj-12310	18	16	evaluation	evaluation	NOUN
ecj-12310	18	17	and	and	CCONJ
ecj-12310	18	18	icp	icp	PROPN
ecj-12310	18	19	monitoring	monitoring	NOUN
ecj-12310	18	20	,	,	PUNCT
ecj-12310	18	21	and	and	CCONJ
ecj-12310	18	22	verified	verify	VERB
ecj-12310	18	23	by	by	ADP
ecj-12310	18	24	imaging	image	VERB
ecj-12310	18	25	testing.5	testing.5	NOUN
ecj-12310	18	26	several	several	ADJ
ecj-12310	18	27	significant	significant	ADJ
ecj-12310	18	28	neurologic	neurologic	ADJ
ecj-12310	18	29	disorders	disorder	NOUN
ecj-12310	18	30	share	share	VERB
ecj-12310	18	31	the	the	DET
ecj-12310	18	32	pathologic	pathologic	ADJ
ecj-12310	18	33	state	state	NOUN
ecj-12310	18	34	of	of	ADP
ecj-12310	18	35	elevated	elevated	ADJ
ecj-12310	18	36	intracranial	intracranial	ADJ
ecj-12310	18	37	pressure	pressure	NOUN
ecj-12310	18	38	,	,	PUNCT
ecj-12310	18	39	which	which	PRON
ecj-12310	18	40	is	be	AUX
ecj-12310	18	41	characterized	characterize	VERB
ecj-12310	18	42	by	by	ADP
ecj-12310	18	43	the	the	DET
ecj-12310	18	44	addition	addition	NOUN
ecj-12310	18	45	of	of	ADP
ecj-12310	18	46	volume	volume	NOUN
ecj-12310	18	47	to	to	ADP
ecj-12310	18	48	the	the	DET
ecj-12310	18	49	cranial	cranial	NOUN
ecj-12310	18	50	vault.5	vault.5	NOUN
ecj-12310	18	51	the	the	DET
ecj-12310	18	52	brain	brain	NOUN
ecj-12310	18	53	,	,	PUNCT
ecj-12310	18	54	cerebrospinal	cerebrospinal	ADJ
ecj-12310	18	55	fluid	fluid	NOUN
ecj-12310	18	56	,	,	PUNCT
ecj-12310	18	57	and	and	CCONJ
ecj-12310	18	58	blood	blood	NOUN
ecj-12310	18	59	are	be	AUX
ecj-12310	18	60	the	the	DET
ecj-12310	18	61	three	three	NUM
ecj-12310	18	62	basic	basic	ADJ
ecj-12310	18	63	elements	element	NOUN
ecj-12310	18	64	of	of	ADP
ecj-12310	18	65	the	the	DET
ecj-12310	18	66	stiff	stiff	ADJ
ecj-12310	18	67	structure	structure	NOUN
ecj-12310	18	68	known	know	VERB
ecj-12310	18	69	as	as	ADP
ecj-12310	18	70	the	the	DET
ecj-12310	18	71	cranium	cranium	NOUN
ecj-12310	18	72	.	.	PUNCT
ecj-12310	19	1	the	the	DET
ecj-12310	19	2	pressure	pressure	NOUN
ecj-12310	19	3	inside	inside	ADP
ecj-12310	19	4	the	the	DET
ecj-12310	19	5	cranial	cranial	ADJ
ecj-12310	19	6	vault	vault	NOUN
ecj-12310	19	7	will	will	AUX
ecj-12310	19	8	rise	rise	VERB
ecj-12310	19	9	with	with	ADP
ecj-12310	19	10	any	any	DET
ecj-12310	19	11	increase	increase	NOUN
ecj-12310	19	12	in	in	ADP
ecj-12310	19	13	the	the	DET
ecj-12310	19	14	volume	volume	NOUN
ecj-12310	19	15	of	of	ADP
ecj-12310	19	16	its	its	PRON
ecj-12310	19	17	contents.6	contents.6	NOUN
ecj-12310	19	18	the	the	DET
ecj-12310	19	19	capacity	capacity	NOUN
ecj-12310	19	20	of	of	ADP
ecj-12310	19	21	the	the	DET
ecj-12310	19	22	human	human	ADJ
ecj-12310	19	23	skull	skull	NOUN
ecj-12310	19	24	ranges	range	VERB
ecj-12310	19	25	from	from	ADP
ecj-12310	19	26	1400	1400	NUM
ecj-12310	19	27	to	to	ADP
ecj-12310	19	28	1700	1700	NUM
ecj-12310	19	29	ml	ml	NOUN
ecj-12310	19	30	,	,	PUNCT
ecj-12310	19	31	and	and	CCONJ
ecj-12310	19	32	it	it	PRON
ecj-12310	19	33	is	be	AUX
ecj-12310	19	34	a	a	DET
ecj-12310	19	35	rather	rather	ADV
ecj-12310	19	36	unchanging	unchanging	ADJ
ecj-12310	19	37	structure	structure	NOUN
ecj-12310	19	38	.	.	PUNCT
ecj-12310	20	1	according	accord	VERB
ecj-12310	20	2	to	to	ADP
ecj-12310	20	3	biology	biology	NOUN
ecj-12310	20	4	,	,	PUNCT
ecj-12310	20	5	it	it	PRON
ecj-12310	20	6	is	be	AUX
ecj-12310	20	7	made	make	VERB
ecj-12310	20	8	up	up	ADP
ecj-12310	20	9	of	of	ADP
ecj-12310	20	10	80	80	NUM
ecj-12310	20	11	%	%	NOUN
ecj-12310	20	12	brain	brain	NOUN
ecj-12310	20	13	parenchyma	parenchyma	NOUN
ecj-12310	20	14	,	,	PUNCT
ecj-12310	20	15	10	10	NUM
ecj-12310	20	16	%	%	NOUN
ecj-12310	20	17	cerebrospinal	cerebrospinal	ADJ
ecj-12310	20	18	fluid	fluid	NOUN
ecj-12310	20	19	,	,	PUNCT
ecj-12310	20	20	and	and	CCONJ
ecj-12310	20	21	10	10	NUM
ecj-12310	20	22	%	%	NOUN
ecj-12310	20	23	blood	blood	NOUN
ecj-12310	20	24	.	.	PUNCT
ecj-12310	21	1	since	since	SCONJ
ecj-12310	21	2	the	the	DET
ecj-12310	21	3	correspondence	correspondence	NOUN
ecj-12310	21	4	:	:	PUNCT
ecj-12310	21	5	nagaraju	nagaraju	PROPN
ecj-12310	21	6	kishore	kishore	PROPN
ecj-12310	21	7	,	,	PUNCT
ecj-12310	21	8	department	department	NOUN
ecj-12310	21	9	of	of	ADP
ecj-12310	21	10	pharmacy	pharmacy	NOUN
ecj-12310	21	11	practice	practice	NOUN
ecj-12310	21	12	,	,	PUNCT
ecj-12310	21	13	faculty	faculty	NOUN
ecj-12310	21	14	of	of	ADP
ecj-12310	21	15	pharmaceutical	pharmaceutical	NOUN
ecj-12310	21	16	sciences	science	NOUN
ecj-12310	21	17	,	,	PUNCT
ecj-12310	21	18	pes	pes	PROPN
ecj-12310	21	19	university	university	PROPN
ecj-12310	21	20	,	,	PUNCT
ecj-12310	21	21	560050	560050	NUM
ecj-12310	21	22	bangalore	bangalore	NOUN
ecj-12310	21	23	,	,	PUNCT
ecj-12310	21	24	india	india	PROPN
ecj-12310	21	25	.	.	PUNCT
ecj-12310	21	26	e	e	X
ecj-12310	21	27	-	-	NOUN
ecj-12310	21	28	mail	mail	NOUN
ecj-12310	21	29	:	:	PUNCT
ecj-12310	21	30	nkishore2468@gmail.com	nkishore2468@gmail.com	X
ecj-12310	22	1	key	key	ADJ
ecj-12310	22	2	words	word	NOUN
ecj-12310	22	3	:	:	PUNCT
ecj-12310	22	4	traumatic	traumatic	ADJ
ecj-12310	22	5	brain	brain	NOUN
ecj-12310	22	6	injury	injury	NOUN
ecj-12310	22	7	,	,	PUNCT
ecj-12310	22	8	mannitol	mannitol	NOUN
ecj-12310	22	9	,	,	PUNCT
ecj-12310	22	10	hypertonic	hypertonic	ADJ
ecj-12310	22	11	saline	saline	NOUN
ecj-12310	22	12	,	,	PUNCT
ecj-12310	22	13	cerebral	cerebral	ADJ
ecj-12310	22	14	edema	edema	NOUN
ecj-12310	22	15	,	,	PUNCT
ecj-12310	22	16	intracranial	intracranial	ADJ
ecj-12310	22	17	pressure	pressure	NOUN
ecj-12310	22	18	,	,	PUNCT
ecj-12310	22	19	brain	brain	NOUN
ecj-12310	22	20	trauma	trauma	NOUN
ecj-12310	22	21	,	,	PUNCT
ecj-12310	22	22	osmotherapy	osmotherapy	NOUN
ecj-12310	22	23	,	,	PUNCT
ecj-12310	22	24	fluid	fluid	ADJ
ecj-12310	22	25	management	management	NOUN
ecj-12310	22	26	.	.	PUNCT
ecj-12310	23	1	contributions	contribution	NOUN
ecj-12310	23	2	:	:	PUNCT
ecj-12310	23	3	nk	nk	PROPN
ecj-12310	23	4	and	and	CCONJ
ecj-12310	23	5	ll	ll	AUX
ecj-12310	23	6	,	,	PUNCT
ecj-12310	23	7	conceived	conceive	VERB
ecj-12310	23	8	and	and	CCONJ
ecj-12310	23	9	designed	design	VERB
ecj-12310	23	10	this	this	DET
ecj-12310	23	11	systematic	systematic	ADJ
ecj-12310	23	12	review	review	NOUN
ecj-12310	23	13	,	,	PUNCT
ecj-12310	23	14	analyzed	analyze	VERB
ecj-12310	23	15	the	the	DET
ecj-12310	23	16	data	datum	NOUN
ecj-12310	23	17	,	,	PUNCT
ecj-12310	23	18	and	and	CCONJ
ecj-12310	23	19	drafted	draft	VERB
ecj-12310	23	20	the	the	DET
ecj-12310	23	21	content	content	NOUN
ecj-12310	23	22	accordingly	accordingly	ADV
ecj-12310	23	23	;	;	PUNCT
ecj-12310	23	24	nk	nk	PROPN
ecj-12310	23	25	,	,	PUNCT
ecj-12310	23	26	ll	ll	AUX
ecj-12310	23	27	,	,	PUNCT
ecj-12310	23	28	and	and	CCONJ
ecj-12310	23	29	ms	ms	PROPN
ecj-12310	23	30	performed	perform	VERB
ecj-12310	23	31	the	the	DET
ecj-12310	23	32	literature	literature	NOUN
ecj-12310	23	33	search	search	NOUN
ecj-12310	23	34	;	;	PUNCT
ecj-12310	23	35	ms	ms	PROPN
ecj-12310	23	36	,	,	PUNCT
ecj-12310	23	37	edited	edit	VERB
ecj-12310	23	38	and	and	CCONJ
ecj-12310	23	39	revised	revise	VERB
ecj-12310	23	40	the	the	DET
ecj-12310	23	41	drafted	drafted	ADJ
ecj-12310	23	42	content	content	NOUN
ecj-12310	23	43	.	.	PUNCT
ecj-12310	24	1	all	all	DET
ecj-12310	24	2	authors	author	NOUN
ecj-12310	24	3	approved	approve	VERB
ecj-12310	24	4	the	the	DET
ecj-12310	24	5	final	final	ADJ
ecj-12310	24	6	version	version	NOUN
ecj-12310	24	7	of	of	ADP
ecj-12310	24	8	the	the	DET
ecj-12310	24	9	paper	paper	NOUN
ecj-12310	24	10	.	.	PUNCT
ecj-12310	25	1	conflict	conflict	NOUN
ecj-12310	25	2	of	of	ADP
ecj-12310	25	3	interest	interest	NOUN
ecj-12310	25	4	:	:	PUNCT
ecj-12310	25	5	the	the	DET
ecj-12310	25	6	authors	author	NOUN
ecj-12310	25	7	declare	declare	VERB
ecj-12310	25	8	no	no	DET
ecj-12310	25	9	potential	potential	ADJ
ecj-12310	25	10	conflict	conflict	NOUN
ecj-12310	25	11	of	of	ADP
ecj-12310	25	12	interest	interest	NOUN
ecj-12310	25	13	,	,	PUNCT
ecj-12310	25	14	and	and	CCONJ
ecj-12310	25	15	all	all	DET
ecj-12310	25	16	authors	author	NOUN
ecj-12310	25	17	confirm	confirm	VERB
ecj-12310	25	18	accuracy	accuracy	NOUN
ecj-12310	25	19	.	.	PUNCT
ecj-12310	26	1	ethics	ethic	NOUN
ecj-12310	26	2	approval	approval	NOUN
ecj-12310	26	3	and	and	CCONJ
ecj-12310	26	4	informed	informed	ADJ
ecj-12310	26	5	consent	consent	NOUN
ecj-12310	26	6	:	:	PUNCT
ecj-12310	26	7	not	not	PART
ecj-12310	26	8	applicable	applicable	ADJ
ecj-12310	26	9	.	.	PUNCT
ecj-12310	27	1	availability	availability	NOUN
ecj-12310	27	2	of	of	ADP
ecj-12310	27	3	data	datum	NOUN
ecj-12310	27	4	and	and	CCONJ
ecj-12310	27	5	materials	material	NOUN
ecj-12310	27	6	:	:	PUNCT
ecj-12310	27	7	all	all	DET
ecj-12310	27	8	data	datum	NOUN
ecj-12310	27	9	generated	generate	VERB
ecj-12310	27	10	or	or	CCONJ
ecj-12310	27	11	analyzed	analyze	VERB
ecj-12310	27	12	during	during	ADP
ecj-12310	27	13	this	this	DET
ecj-12310	27	14	study	study	NOUN
ecj-12310	27	15	are	be	AUX
ecj-12310	27	16	included	include	VERB
ecj-12310	27	17	in	in	ADP
ecj-12310	27	18	this	this	DET
ecj-12310	27	19	published	publish	VERB
ecj-12310	27	20	article	article	NOUN
ecj-12310	27	21	.	.	PUNCT
ecj-12310	28	1	received	receive	VERB
ecj-12310	28	2	:	:	PUNCT
ecj-12310	28	3	25	25	NUM
ecj-12310	28	4	january	january	PROPN
ecj-12310	28	5	2024	2024	NUM
ecj-12310	28	6	.	.	PUNCT
ecj-12310	29	1	accepted	accept	VERB
ecj-12310	29	2	:	:	PUNCT
ecj-12310	29	3	29	29	NUM
ecj-12310	29	4	april	april	PROPN
ecj-12310	29	5	2024	2024	NUM
ecj-12310	29	6	.	.	PUNCT
ecj-12310	30	1	early	early	ADJ
ecj-12310	30	2	view	view	NOUN
ecj-12310	30	3	:	:	PUNCT
ecj-12310	30	4	27	27	NUM
ecj-12310	30	5	may	may	PROPN
ecj-12310	30	6	2024	2024	NUM
ecj-12310	30	7	.	.	PUNCT
ecj-12310	31	1	this	this	DET
ecj-12310	31	2	work	work	NOUN
ecj-12310	31	3	is	be	AUX
ecj-12310	31	4	licensed	license	VERB
ecj-12310	31	5	under	under	ADP
ecj-12310	31	6	a	a	DET
ecj-12310	31	7	creative	creative	ADJ
ecj-12310	31	8	commons	common	NOUN
ecj-12310	31	9	attribution	attribution	NOUN
ecj-12310	31	10	4.0	4.0	NUM
ecj-12310	31	11	license	license	NOUN
ecj-12310	31	12	(	(	PUNCT
ecj-12310	31	13	by	by	ADP
ecj-12310	31	14	-	-	PUNCT
ecj-12310	31	15	nc	nc	PROPN
ecj-12310	31	16	4.0	4.0	NUM
ecj-12310	31	17	)	)	PUNCT
ecj-12310	31	18	.	.	PUNCT
ecj-12310	32	1	©	©	PROPN
ecj-12310	32	2	copyright	copyright	NOUN
ecj-12310	32	3	:	:	PUNCT
ecj-12310	32	4	the	the	DET
ecj-12310	32	5	author(s	author(s	PROPN
ecj-12310	32	6	)	)	PUNCT
ecj-12310	32	7	,	,	PUNCT
ecj-12310	32	8	2024	2024	NUM
ecj-12310	32	9	licensee	licensee	NOUN
ecj-12310	32	10	pagepress	pagepress	NOUN
ecj-12310	32	11	,	,	PUNCT
ecj-12310	32	12	italy	italy	PROPN
ecj-12310	32	13	emergency	emergency	PROPN
ecj-12310	32	14	care	care	PROPN
ecj-12310	32	15	journal	journal	PROPN
ecj-12310	32	16	2024	2024	NUM
ecj-12310	32	17	;	;	PUNCT
ecj-12310	32	18	20:12310	20:12310	NUM
ecj-12310	32	19	doi:10.4081	doi:10.4081	NOUN
ecj-12310	32	20	/	/	SYM
ecj-12310	32	21	ecj.2024.12310	ecj.2024.12310	PROPN
ecj-12310	32	22	publisher	publisher	NOUN
ecj-12310	32	23	's	's	PART
ecj-12310	32	24	note	note	NOUN
ecj-12310	32	25	:	:	PUNCT
ecj-12310	32	26	all	all	DET
ecj-12310	32	27	claims	claim	NOUN
ecj-12310	32	28	expressed	express	VERB
ecj-12310	32	29	in	in	ADP
ecj-12310	32	30	this	this	DET
ecj-12310	32	31	article	article	NOUN
ecj-12310	32	32	are	be	AUX
ecj-12310	32	33	solely	solely	ADV
ecj-12310	32	34	those	those	PRON
ecj-12310	32	35	of	of	ADP
ecj-12310	32	36	the	the	DET
ecj-12310	32	37	authors	author	NOUN
ecj-12310	32	38	and	and	CCONJ
ecj-12310	32	39	do	do	AUX
ecj-12310	32	40	not	not	PART
ecj-12310	32	41	necessarily	necessarily	ADV
ecj-12310	32	42	represent	represent	VERB
ecj-12310	32	43	those	those	PRON
ecj-12310	32	44	of	of	ADP
ecj-12310	32	45	their	their	PRON
ecj-12310	32	46	affiliated	affiliated	ADJ
ecj-12310	32	47	organizations	organization	NOUN
ecj-12310	32	48	,	,	PUNCT
ecj-12310	32	49	or	or	CCONJ
ecj-12310	32	50	those	those	PRON
ecj-12310	32	51	of	of	ADP
ecj-12310	32	52	the	the	DET
ecj-12310	32	53	publisher	publisher	NOUN
ecj-12310	32	54	,	,	PUNCT
ecj-12310	32	55	the	the	DET
ecj-12310	32	56	editors	editor	NOUN
ecj-12310	32	57	and	and	CCONJ
ecj-12310	32	58	the	the	DET
ecj-12310	32	59	reviewers	reviewer	NOUN
ecj-12310	32	60	.	.	PUNCT
ecj-12310	33	1	any	any	DET
ecj-12310	33	2	product	product	NOUN
ecj-12310	33	3	that	that	PRON
ecj-12310	33	4	may	may	AUX
ecj-12310	33	5	be	be	AUX
ecj-12310	33	6	evaluated	evaluate	VERB
ecj-12310	33	7	in	in	ADP
ecj-12310	33	8	this	this	DET
ecj-12310	33	9	article	article	NOUN
ecj-12310	33	10	or	or	CCONJ
ecj-12310	33	11	claim	claim	NOUN
ecj-12310	33	12	that	that	PRON
ecj-12310	33	13	may	may	AUX
ecj-12310	33	14	be	be	AUX
ecj-12310	33	15	made	make	VERB
ecj-12310	33	16	by	by	ADP
ecj-12310	33	17	its	its	PRON
ecj-12310	33	18	manufacturer	manufacturer	NOUN
ecj-12310	33	19	is	be	AUX
ecj-12310	33	20	not	not	PART
ecj-12310	33	21	guaranteed	guarantee	VERB
ecj-12310	33	22	or	or	CCONJ
ecj-12310	33	23	endorsed	endorse	VERB
ecj-12310	33	24	by	by	ADP
ecj-12310	33	25	the	the	DET
ecj-12310	33	26	publisher	publisher	NOUN
ecj-12310	33	27	.	.	PUNCT
ecj-12310	34	1	comparative	comparative	ADJ
ecj-12310	34	2	efficacy	efficacy	NOUN
ecj-12310	34	3	analysis	analysis	NOUN
ecj-12310	34	4	of	of	ADP
ecj-12310	34	5	mannitol	mannitol	NOUN
ecj-12310	34	6	and	and	CCONJ
ecj-12310	34	7	hypertonic	hypertonic	ADJ
ecj-12310	34	8	saline	saline	NOUN
ecj-12310	34	9	in	in	ADP
ecj-12310	34	10	the	the	DET
ecj-12310	34	11	management	management	NOUN
ecj-12310	34	12	of	of	ADP
ecj-12310	34	13	traumatic	traumatic	ADJ
ecj-12310	34	14	brain	brain	NOUN
ecj-12310	34	15	injury	injury	NOUN
ecj-12310	34	16	:	:	PUNCT
ecj-12310	34	17	a	a	DET
ecj-12310	34	18	scientific	scientific	ADJ
ecj-12310	34	19	exploration	exploration	NOUN
ecj-12310	34	20	of	of	ADP
ecj-12310	34	21	neuroprotective	neuroprotective	ADJ
ecj-12310	34	22	strategies	strategy	NOUN
ecj-12310	34	23	nagaraju	nagaraju	PROPN
ecj-12310	34	24	kishore	kishore	PROPN
ecj-12310	34	25	,	,	PUNCT
ecj-12310	34	26	leema	leema	PROPN
ecj-12310	34	27	lobo	lobo	PROPN
ecj-12310	34	28	,	,	PUNCT
ecj-12310	34	29	manjari	manjari	PROPN
ecj-12310	34	30	sharma	sharma	PROPN
ecj-12310	34	31	department	department	PROPN
ecj-12310	34	32	of	of	ADP
ecj-12310	34	33	pharmacy	pharmacy	NOUN
ecj-12310	34	34	practice	practice	NOUN
ecj-12310	34	35	,	,	PUNCT
ecj-12310	34	36	faculty	faculty	NOUN
ecj-12310	34	37	of	of	ADP
ecj-12310	34	38	pharmaceutical	pharmaceutical	NOUN
ecj-12310	34	39	sciences	science	NOUN
ecj-12310	34	40	,	,	PUNCT
ecj-12310	34	41	pes	pes	PROPN
ecj-12310	34	42	university	university	PROPN
ecj-12310	34	43	,	,	PUNCT
ecj-12310	34	44	bangalore	bangalore	PROPN
ecj-12310	34	45	,	,	PUNCT
ecj-12310	34	46	india	india	PROPN
ecj-12310	34	47	non	non	PROPN
ecj-12310	34	48	-co	-co	PROPN
ecj-12310	34	49	mmerc	mmerc	PROPN
ecj-12310	34	50	ial	ial	PROPN
ecj-12310	34	51	us	us	PROPN
ecj-12310	34	52	e	e	NOUN
ecj-12310	34	53	o	o	PROPN
ecj-12310	34	54	nly	nly	ADV
ecj-12310	34	55	skull	skull	NOUN
ecj-12310	34	56	is	be	AUX
ecj-12310	34	57	thought	think	VERB
ecj-12310	34	58	to	to	PART
ecj-12310	34	59	be	be	AUX
ecj-12310	34	60	an	an	DET
ecj-12310	34	61	immutable	immutable	ADJ
ecj-12310	34	62	volume	volume	NOUN
ecj-12310	34	63	,	,	PUNCT
ecj-12310	34	64	any	any	DET
ecj-12310	34	65	rise	rise	NOUN
ecj-12310	34	66	in	in	ADP
ecj-12310	34	67	the	the	DET
ecj-12310	34	68	volume	volume	NOUN
ecj-12310	34	69	of	of	ADP
ecj-12310	34	70	its	its	PRON
ecj-12310	34	71	constituent	constituent	ADJ
ecj-12310	34	72	parts	part	NOUN
ecj-12310	34	73	or	or	CCONJ
ecj-12310	34	74	the	the	DET
ecj-12310	34	75	inclusion	inclusion	NOUN
ecj-12310	34	76	of	of	ADP
ecj-12310	34	77	a	a	DET
ecj-12310	34	78	pathologic	pathologic	ADJ
ecj-12310	34	79	component	component	NOUN
ecj-12310	34	80	will	will	AUX
ecj-12310	34	81	lead	lead	VERB
ecj-12310	34	82	to	to	ADP
ecj-12310	34	83	an	an	DET
ecj-12310	34	84	increase	increase	NOUN
ecj-12310	34	85	in	in	ADP
ecj-12310	34	86	pressure	pressure	NOUN
ecj-12310	34	87	inside	inside	ADP
ecj-12310	34	88	the	the	DET
ecj-12310	34	89	skull.7	skull.7	NOUN
ecj-12310	34	90	increased	increase	VERB
ecj-12310	34	91	icp	icp	PROPN
ecj-12310	34	92	may	may	AUX
ecj-12310	34	93	result	result	VERB
ecj-12310	34	94	from	from	ADP
ecj-12310	34	95	cerebral	cerebral	ADJ
ecj-12310	34	96	edema	edema	NOUN
ecj-12310	34	97	or	or	CCONJ
ecj-12310	34	98	mass	mass	ADJ
ecj-12310	34	99	lesions	lesion	NOUN
ecj-12310	34	100	in	in	ADP
ecj-12310	34	101	patients	patient	NOUN
ecj-12310	34	102	with	with	ADP
ecj-12310	34	103	traumatic	traumatic	ADJ
ecj-12310	34	104	brain	brain	NOUN
ecj-12310	34	105	injury	injury	NOUN
ecj-12310	34	106	(	(	PUNCT
ecj-12310	34	107	tbi	tbi	NOUN
ecj-12310	34	108	)	)	PUNCT
ecj-12310	34	109	.	.	PUNCT
ecj-12310	35	1	ischemia	ischemia	NOUN
ecj-12310	35	2	and	and	CCONJ
ecj-12310	35	3	subsequent	subsequent	ADJ
ecj-12310	35	4	brain	brain	NOUN
ecj-12310	35	5	damage	damage	NOUN
ecj-12310	35	6	may	may	AUX
ecj-12310	35	7	result	result	VERB
ecj-12310	35	8	from	from	ADP
ecj-12310	35	9	elevated	elevated	ADJ
ecj-12310	35	10	icp	icp	PROPN
ecj-12310	35	11	because	because	SCONJ
ecj-12310	35	12	it	it	PRON
ecj-12310	35	13	lowers	lower	VERB
ecj-12310	35	14	cerebral	cerebral	ADJ
ecj-12310	35	15	perfusion	perfusion	NOUN
ecj-12310	35	16	pressure	pressure	NOUN
ecj-12310	35	17	(	(	PUNCT
ecj-12310	35	18	cpp	cpp	NOUN
ecj-12310	35	19	)	)	PUNCT
ecj-12310	35	20	to	to	ADP
ecj-12310	35	21	the	the	DET
ecj-12310	35	22	point	point	NOUN
ecj-12310	35	23	where	where	SCONJ
ecj-12310	35	24	cerebral	cerebral	ADJ
ecj-12310	35	25	blood	blood	NOUN
ecj-12310	35	26	flow	flow	NOUN
ecj-12310	35	27	(	(	PUNCT
ecj-12310	35	28	cbf	cbf	PROPN
ecj-12310	35	29	)	)	PUNCT
ecj-12310	35	30	may	may	AUX
ecj-12310	35	31	deteriorate	deteriorate	VERB
ecj-12310	35	32	significantly.8	significantly.8	PROPN
ecj-12310	35	33	tbi	tbi	PROPN
ecj-12310	35	34	,	,	PUNCT
ecj-12310	35	35	stroke	stroke	NOUN
ecj-12310	35	36	,	,	PUNCT
ecj-12310	35	37	intracranial	intracranial	ADJ
ecj-12310	35	38	hemorrhage	hemorrhage	NOUN
ecj-12310	35	39	,	,	PUNCT
ecj-12310	35	40	intracranial	intracranial	ADJ
ecj-12310	35	41	infection	infection	NOUN
ecj-12310	35	42	,	,	PUNCT
ecj-12310	35	43	hydrocephalus	hydrocephalus	X
ecj-12310	35	44	,	,	PUNCT
ecj-12310	35	45	brain	brain	NOUN
ecj-12310	35	46	tumor	tumor	NOUN
ecj-12310	35	47	,	,	PUNCT
ecj-12310	35	48	as	as	ADV
ecj-12310	35	49	well	well	ADV
ecj-12310	35	50	as	as	ADP
ecj-12310	35	51	other	other	ADJ
ecj-12310	35	52	neurological	neurological	ADJ
ecj-12310	35	53	diseases	disease	NOUN
ecj-12310	35	54	,	,	PUNCT
ecj-12310	35	55	can	can	AUX
ecj-12310	35	56	all	all	PRON
ecj-12310	35	57	result	result	VERB
ecj-12310	35	58	in	in	ADP
ecj-12310	35	59	raised	raise	VERB
ecj-12310	35	60	icp	icp	PROPN
ecj-12310	35	61	as	as	ADP
ecj-12310	35	62	a	a	DET
ecj-12310	35	63	consequence.9	consequence.9	NOUN
ecj-12310	35	64	the	the	DET
ecj-12310	35	65	location	location	NOUN
ecj-12310	35	66	and	and	CCONJ
ecj-12310	35	67	degree	degree	NOUN
ecj-12310	35	68	of	of	ADP
ecj-12310	35	69	brain	brain	NOUN
ecj-12310	35	70	damage	damage	NOUN
ecj-12310	35	71	due	due	ADP
ecj-12310	35	72	to	to	ADP
ecj-12310	35	73	increased	increase	VERB
ecj-12310	35	74	icp	icp	PROPN
ecj-12310	35	75	are	be	AUX
ecj-12310	35	76	related	relate	VERB
ecj-12310	35	77	to	to	ADP
ecj-12310	35	78	the	the	DET
ecj-12310	35	79	neurological	neurological	ADJ
ecj-12310	35	80	outcome	outcome	NOUN
ecj-12310	35	81	,	,	PUNCT
ecj-12310	35	82	although	although	SCONJ
ecj-12310	35	83	edema	edema	NOUN
ecj-12310	35	84	or	or	CCONJ
ecj-12310	35	85	infarction	infarction	NOUN
ecj-12310	35	86	of	of	ADP
ecj-12310	35	87	the	the	DET
ecj-12310	35	88	perilesional	perilesional	ADJ
ecj-12310	35	89	tissue	tissue	NOUN
ecj-12310	35	90	are	be	AUX
ecj-12310	35	91	also	also	ADV
ecj-12310	35	92	causally	causally	ADV
ecj-12310	35	93	related	relate	VERB
ecj-12310	35	94	to	to	ADP
ecj-12310	35	95	permanent	permanent	ADJ
ecj-12310	35	96	deterioration	deterioration	NOUN
ecj-12310	35	97	and	and	CCONJ
ecj-12310	35	98	death.10	death.10	VERB
ecj-12310	35	99	management	management	NOUN
ecj-12310	35	100	of	of	ADP
ecj-12310	35	101	the	the	DET
ecj-12310	35	102	intracranial	intracranial	ADJ
ecj-12310	35	103	hypertension	hypertension	NOUN
ecj-12310	35	104	after	after	ADP
ecj-12310	35	105	supportive	supportive	ADJ
ecj-12310	35	106	care	care	NOUN
ecj-12310	35	107	,	,	PUNCT
ecj-12310	35	108	which	which	PRON
ecj-12310	35	109	is	be	AUX
ecj-12310	35	110	crucial	crucial	ADJ
ecj-12310	35	111	for	for	ADP
ecj-12310	35	112	neuroprotection	neuroprotection	NOUN
ecj-12310	35	113	,	,	PUNCT
ecj-12310	35	114	hyperosmolar	hyperosmolar	ADJ
ecj-12310	35	115	treatment	treatment	NOUN
ecj-12310	35	116	is	be	AUX
ecj-12310	35	117	the	the	DET
ecj-12310	35	118	medical	medical	ADJ
ecj-12310	35	119	standard	standard	NOUN
ecj-12310	35	120	for	for	ADP
ecj-12310	35	121	treating	treat	VERB
ecj-12310	35	122	ich	ich	PROPN
ecj-12310	35	123	.	.	PUNCT
ecj-12310	36	1	mannitol	mannitol	NOUN
ecj-12310	36	2	and	and	CCONJ
ecj-12310	36	3	hypertonic	hypertonic	ADJ
ecj-12310	36	4	saline	saline	NOUN
ecj-12310	36	5	are	be	AUX
ecj-12310	36	6	the	the	DET
ecj-12310	36	7	two	two	NUM
ecj-12310	36	8	osmotic	osmotic	ADJ
ecj-12310	36	9	agents	agent	NOUN
ecj-12310	36	10	currently	currently	ADV
ecj-12310	36	11	used	use	VERB
ecj-12310	36	12	for	for	ADP
ecj-12310	36	13	this	this	DET
ecj-12310	36	14	purpose.11	purpose.11	PROPN
ecj-12310	36	15	the	the	DET
ecj-12310	36	16	application	application	NOUN
ecj-12310	36	17	of	of	ADP
ecj-12310	36	18	hyperosmolar	hyperosmolar	ADJ
ecj-12310	36	19	solutions	solution	NOUN
ecj-12310	36	20	has	have	AUX
ecj-12310	36	21	been	be	AUX
ecj-12310	36	22	one	one	NUM
ecj-12310	36	23	of	of	ADP
ecj-12310	36	24	the	the	DET
ecj-12310	36	25	main	main	ADJ
ecj-12310	36	26	medical	medical	ADJ
ecj-12310	36	27	treatments	treatment	NOUN
ecj-12310	36	28	for	for	ADP
ecj-12310	36	29	cerebral	cerebral	ADJ
ecj-12310	36	30	edema	edema	NOUN
ecj-12310	36	31	.	.	PUNCT
ecj-12310	37	1	over	over	ADP
ecj-12310	37	2	the	the	DET
ecj-12310	37	3	past	past	ADJ
ecj-12310	37	4	century	century	NOUN
ecj-12310	37	5	,	,	PUNCT
ecj-12310	37	6	there	there	PRON
ecj-12310	37	7	has	have	AUX
ecj-12310	37	8	been	be	AUX
ecj-12310	37	9	a	a	DET
ecj-12310	37	10	significant	significant	ADJ
ecj-12310	37	11	evolution	evolution	NOUN
ecj-12310	37	12	in	in	ADP
ecj-12310	37	13	the	the	DET
ecj-12310	37	14	therapeutic	therapeutic	ADJ
ecj-12310	37	15	targets	target	NOUN
ecj-12310	37	16	,	,	PUNCT
ecj-12310	37	17	the	the	DET
ecj-12310	37	18	medicines	medicine	NOUN
ecj-12310	37	19	utilized	utilize	VERB
ecj-12310	37	20	,	,	PUNCT
ecj-12310	37	21	and	and	CCONJ
ecj-12310	37	22	how	how	SCONJ
ecj-12310	37	23	they	they	PRON
ecj-12310	37	24	are	be	AUX
ecj-12310	37	25	administered	administer	VERB
ecj-12310	37	26	.	.	PUNCT
ecj-12310	38	1	the	the	DET
ecj-12310	38	2	first	first	ADJ
ecj-12310	38	3	to	to	PART
ecj-12310	38	4	describe	describe	VERB
ecj-12310	38	5	the	the	DET
ecj-12310	38	6	ability	ability	NOUN
ecj-12310	38	7	of	of	ADP
ecj-12310	38	8	hyperosmolar	hyperosmolar	ADJ
ecj-12310	38	9	liquids	liquid	NOUN
ecj-12310	38	10	to	to	PART
ecj-12310	38	11	reduce	reduce	VERB
ecj-12310	38	12	nerve	nerve	NOUN
ecj-12310	38	13	tissue	tissue	NOUN
ecj-12310	38	14	was	be	AUX
ecj-12310	38	15	weed	weed	NOUN
ecj-12310	38	16	and	and	CCONJ
ecj-12310	38	17	mckibbens	mckibben	NOUN
ecj-12310	38	18	in	in	ADP
ecj-12310	38	19	1919	1919	NUM
ecj-12310	38	20	.	.	PUNCT
ecj-12310	39	1	they	they	PRON
ecj-12310	39	2	discovered	discover	VERB
ecj-12310	39	3	that	that	SCONJ
ecj-12310	39	4	administering	administer	VERB
ecj-12310	39	5	free	free	ADJ
ecj-12310	39	6	water	water	NOUN
ecj-12310	39	7	caused	cause	VERB
ecj-12310	39	8	brain	brain	NOUN
ecj-12310	39	9	swelling	swell	VERB
ecj-12310	39	10	while	while	SCONJ
ecj-12310	39	11	infusing	infuse	VERB
ecj-12310	39	12	a	a	DET
ecj-12310	39	13	30	30	NUM
ecj-12310	39	14	%	%	NOUN
ecj-12310	39	15	saline	saline	NOUN
ecj-12310	39	16	solution	solution	NOUN
ecj-12310	39	17	significantly	significantly	ADV
ecj-12310	39	18	reduced	reduce	VERB
ecj-12310	39	19	brain	brain	NOUN
ecj-12310	39	20	volume.12	volume.12	NOUN
ecj-12310	39	21	several	several	ADJ
ecj-12310	39	22	substances	substance	NOUN
ecj-12310	39	23	,	,	PUNCT
ecj-12310	39	24	including	include	VERB
ecj-12310	39	25	50	50	NUM
ecj-12310	39	26	%	%	NOUN
ecj-12310	39	27	glucose	glucose	NOUN
ecj-12310	39	28	,	,	PUNCT
ecj-12310	39	29	50	50	NUM
ecj-12310	39	30	%	%	NOUN
ecj-12310	39	31	sucrose	sucrose	NOUN
ecj-12310	39	32	,	,	PUNCT
ecj-12310	39	33	25	25	NUM
ecj-12310	39	34	%	%	NOUN
ecj-12310	39	35	sodium	sodium	NOUN
ecj-12310	39	36	chloride	chloride	NOUN
ecj-12310	39	37	,	,	PUNCT
ecj-12310	39	38	25	25	NUM
ecj-12310	39	39	%	%	NOUN
ecj-12310	39	40	urea	urea	NOUN
ecj-12310	39	41	,	,	PUNCT
ecj-12310	39	42	50	50	NUM
ecj-12310	39	43	%	%	NOUN
ecj-12310	39	44	magnesium	magnesium	NOUN
ecj-12310	39	45	sulfate	sulfate	NOUN
ecj-12310	39	46	,	,	PUNCT
ecj-12310	39	47	glycerol	glycerol	NOUN
ecj-12310	39	48	,	,	PUNCT
ecj-12310	39	49	concentrated	concentrated	ADJ
ecj-12310	39	50	albumin	albumin	NOUN
ecj-12310	39	51	,	,	PUNCT
ecj-12310	39	52	and	and	CCONJ
ecj-12310	39	53	concentrated	concentrated	ADJ
ecj-12310	39	54	plasma	plasma	NOUN
ecj-12310	39	55	,	,	PUNCT
ecj-12310	39	56	were	be	AUX
ecj-12310	39	57	examined	examine	VERB
ecj-12310	39	58	for	for	ADP
ecj-12310	39	59	the	the	DET
ecj-12310	39	60	purpose	purpose	NOUN
ecj-12310	39	61	.	.	PUNCT
ecj-12310	40	1	the	the	DET
ecj-12310	40	2	warning	warning	NOUN
ecj-12310	40	3	that	that	SCONJ
ecj-12310	40	4	“	"	PUNCT
ecj-12310	40	5	most	most	ADJ
ecj-12310	40	6	of	of	ADP
ecj-12310	40	7	these	these	DET
ecj-12310	40	8	dehydrating	dehydrate	VERB
ecj-12310	40	9	substances	substance	NOUN
ecj-12310	40	10	have	have	AUX
ecj-12310	40	11	only	only	ADV
ecj-12310	40	12	a	a	DET
ecj-12310	40	13	transient	transient	ADJ
ecj-12310	40	14	effect	effect	NOUN
ecj-12310	40	15	,	,	PUNCT
ecj-12310	40	16	which	which	PRON
ecj-12310	40	17	may	may	AUX
ecj-12310	40	18	be	be	AUX
ecj-12310	40	19	followed	follow	VERB
ecj-12310	40	20	by	by	ADP
ecj-12310	40	21	a	a	DET
ecj-12310	40	22	“	"	PUNCT
ecj-12310	40	23	rebound	rebound	NOUN
ecj-12310	40	24	phenomenon	phenomenon	NOUN
ecj-12310	40	25	”	"	PUNCT
ecj-12310	40	26	during	during	ADP
ecj-12310	40	27	which	which	PRON
ecj-12310	40	28	the	the	DET
ecj-12310	40	29	intracranial	intracranial	ADJ
ecj-12310	40	30	pressure	pressure	NOUN
ecj-12310	40	31	can	can	AUX
ecj-12310	40	32	rise	rise	VERB
ecj-12310	40	33	above	above	ADP
ecj-12310	40	34	that	that	PRON
ecj-12310	40	35	which	which	PRON
ecj-12310	40	36	existed	exist	VERB
ecj-12310	40	37	before	before	ADP
ecj-12310	40	38	their	their	PRON
ecj-12310	40	39	administration	administration	NOUN
ecj-12310	40	40	”	"	PUNCT
ecj-12310	40	41	was	be	AUX
ecj-12310	40	42	included	include	VERB
ecj-12310	40	43	in	in	ADP
ecj-12310	40	44	the	the	DET
ecj-12310	40	45	literature	literature	NOUN
ecj-12310	40	46	used	use	VERB
ecj-12310	40	47	to	to	PART
ecj-12310	40	48	temper	temper	VERB
ecj-12310	40	49	its	its	PRON
ecj-12310	40	50	use.13	use.13	NOUN
ecj-12310	40	51	however	however	ADV
ecj-12310	40	52	,	,	PUNCT
ecj-12310	40	53	during	during	ADP
ecj-12310	40	54	neurosurgery	neurosurgery	NOUN
ecj-12310	40	55	or	or	CCONJ
ecj-12310	40	56	critical	critical	ADJ
ecj-12310	40	57	care	care	NOUN
ecj-12310	40	58	unit	unit	NOUN
ecj-12310	40	59	admissions	admission	NOUN
ecj-12310	40	60	,	,	PUNCT
ecj-12310	40	61	hyperosmolar	hyperosmolar	ADJ
ecj-12310	40	62	solutions	solution	NOUN
ecj-12310	40	63	are	be	AUX
ecj-12310	40	64	frequently	frequently	ADV
ecj-12310	40	65	used	use	VERB
ecj-12310	40	66	to	to	PART
ecj-12310	40	67	lower	lower	VERB
ecj-12310	40	68	icp	icp	PROPN
ecj-12310	40	69	and	and	CCONJ
ecj-12310	40	70	brain	brain	NOUN
ecj-12310	40	71	volume.14	volume.14	PROPN
ecj-12310	40	72	mannitol	mannitol	NOUN
ecj-12310	40	73	brain	brain	NOUN
ecj-12310	40	74	edema	edema	NOUN
ecj-12310	40	75	can	can	AUX
ecj-12310	40	76	be	be	AUX
ecj-12310	40	77	caused	cause	VERB
ecj-12310	40	78	by	by	ADP
ecj-12310	40	79	a	a	DET
ecj-12310	40	80	variety	variety	NOUN
ecj-12310	40	81	of	of	ADP
ecj-12310	40	82	neurosurgical	neurosurgical	ADJ
ecj-12310	40	83	conditions	condition	NOUN
ecj-12310	40	84	,	,	PUNCT
ecj-12310	40	85	most	most	ADV
ecj-12310	40	86	notably	notably	ADV
ecj-12310	40	87	craniocerebral	craniocerebral	ADJ
ecj-12310	40	88	trauma	trauma	NOUN
ecj-12310	40	89	,	,	PUNCT
ecj-12310	40	90	which	which	PRON
ecj-12310	40	91	can	can	AUX
ecj-12310	40	92	then	then	ADV
ecj-12310	40	93	increase	increase	VERB
ecj-12310	40	94	icp	icp	PROPN
ecj-12310	40	95	.	.	PUNCT
ecj-12310	41	1	the	the	DET
ecj-12310	41	2	main	main	ADJ
ecj-12310	41	3	factor	factor	NOUN
ecj-12310	41	4	that	that	PRON
ecj-12310	41	5	causes	cause	VERB
ecj-12310	41	6	mortality	mortality	NOUN
ecj-12310	41	7	among	among	ADP
ecj-12310	41	8	individuals	individual	NOUN
ecj-12310	41	9	with	with	ADP
ecj-12310	41	10	acute	acute	ADJ
ecj-12310	41	11	cerebral	cerebral	ADJ
ecj-12310	41	12	edema	edema	NOUN
ecj-12310	41	13	is	be	AUX
ecj-12310	41	14	thought	think	VERB
ecj-12310	41	15	to	to	PART
ecj-12310	41	16	be	be	AUX
ecj-12310	41	17	elevated	elevated	ADJ
ecj-12310	41	18	pressure	pressure	NOUN
ecj-12310	41	19	.	.	PUNCT
ecj-12310	42	1	mannitol	mannitol	NOUN
ecj-12310	42	2	’s	’s	PART
ecj-12310	42	3	usefulness	usefulness	NOUN
ecj-12310	42	4	as	as	ADP
ecj-12310	42	5	a	a	DET
ecj-12310	42	6	regularly	regularly	ADV
ecj-12310	42	7	used	use	VERB
ecj-12310	42	8	medication	medication	NOUN
ecj-12310	42	9	to	to	PART
ecj-12310	42	10	lower	low	ADJ
ecj-12310	42	11	icp	icp	PROPN
ecj-12310	42	12	has	have	AUX
ecj-12310	42	13	long	long	ADV
ecj-12310	42	14	been	be	AUX
ecj-12310	42	15	acknowledged.15	acknowledged.15	NOUN
ecj-12310	42	16	1,2,3,4,5,6	1,2,3,4,5,6	NUM
ecj-12310	42	17	-	-	PUNCT
ecj-12310	42	18	hexanehexol	hexanehexol	NOUN
ecj-12310	42	19	,	,	PUNCT
ecj-12310	42	20	often	often	ADV
ecj-12310	42	21	known	know	VERB
ecj-12310	42	22	as	as	ADP
ecj-12310	42	23	mannitol	mannitol	NOUN
ecj-12310	42	24	(	(	PUNCT
ecj-12310	42	25	c6h8(oh)6	c6h8(oh)6	PROPN
ecj-12310	42	26	)	)	PUNCT
ecj-12310	42	27	,	,	PUNCT
ecj-12310	42	28	is	be	AUX
ecj-12310	42	29	a	a	DET
ecj-12310	42	30	naturally	naturally	ADV
ecj-12310	42	31	occurring	occur	VERB
ecj-12310	42	32	polyol	polyol	NOUN
ecj-12310	42	33	that	that	PRON
ecj-12310	42	34	is	be	AUX
ecj-12310	42	35	largely	largely	ADV
ecj-12310	42	36	employed	employ	VERB
ecj-12310	42	37	for	for	ADP
ecj-12310	42	38	its	its	PRON
ecj-12310	42	39	osmotic	osmotic	ADJ
ecj-12310	42	40	diuretic	diuretic	ADJ
ecj-12310	42	41	characteristics	characteristic	NOUN
ecj-12310	42	42	.	.	PUNCT
ecj-12310	43	1	mannitol	mannitol	NOUN
ecj-12310	43	2	decreases	decrease	VERB
ecj-12310	43	3	icp	icp	PROPN
ecj-12310	43	4	by	by	ADP
ecj-12310	43	5	raising	raise	VERB
ecj-12310	43	6	intravascular	intravascular	ADJ
ecj-12310	43	7	osmotic	osmotic	ADJ
ecj-12310	43	8	pressure	pressure	NOUN
ecj-12310	43	9	,	,	PUNCT
ecj-12310	43	10	which	which	PRON
ecj-12310	43	11	draws	draw	VERB
ecj-12310	43	12	extracellular	extracellular	ADJ
ecj-12310	43	13	fluid	fluid	NOUN
ecj-12310	43	14	into	into	ADP
ecj-12310	43	15	the	the	DET
ecj-12310	43	16	intravascular	intravascular	ADJ
ecj-12310	43	17	compartment	compartment	NOUN
ecj-12310	43	18	since	since	SCONJ
ecj-12310	43	19	it	it	PRON
ecj-12310	43	20	can	can	AUX
ecj-12310	43	21	not	not	PART
ecj-12310	43	22	cross	cross	VERB
ecj-12310	43	23	the	the	DET
ecj-12310	43	24	endothelium	endothelium	NOUN
ecj-12310	43	25	membrane	membrane	NOUN
ecj-12310	43	26	.	.	PUNCT
ecj-12310	44	1	by	by	ADP
ecj-12310	44	2	increasing	increase	VERB
ecj-12310	44	3	plasma	plasma	NOUN
ecj-12310	44	4	volume	volume	NOUN
ecj-12310	44	5	,	,	PUNCT
ecj-12310	44	6	mannitol	mannitol	NOUN
ecj-12310	44	7	initially	initially	ADV
ecj-12310	44	8	reduces	reduce	VERB
ecj-12310	44	9	blood	blood	NOUN
ecj-12310	44	10	viscosity	viscosity	NOUN
ecj-12310	44	11	while	while	SCONJ
ecj-12310	44	12	also	also	ADV
ecj-12310	44	13	increasing	increase	VERB
ecj-12310	44	14	microvascular	microvascular	ADJ
ecj-12310	44	15	flow	flow	NOUN
ecj-12310	44	16	and	and	CCONJ
ecj-12310	44	17	tissue	tissue	NOUN
ecj-12310	44	18	oxygenation	oxygenation	NOUN
ecj-12310	44	19	.	.	PUNCT
ecj-12310	45	1	increased	increase	VERB
ecj-12310	45	2	tissue	tissue	NOUN
ecj-12310	45	3	perfusion	perfusion	NOUN
ecj-12310	45	4	causes	cause	VERB
ecj-12310	45	5	a	a	DET
ecj-12310	45	6	vasoconstriction	vasoconstriction	NOUN
ecj-12310	45	7	reflex	reflex	NOUN
ecj-12310	45	8	,	,	PUNCT
ecj-12310	45	9	which	which	PRON
ecj-12310	45	10	reduces	reduce	VERB
ecj-12310	45	11	blood	blood	NOUN
ecj-12310	45	12	flow	flow	NOUN
ecj-12310	45	13	to	to	ADP
ecj-12310	45	14	the	the	DET
ecj-12310	45	15	brain	brain	NOUN
ecj-12310	45	16	and	and	CCONJ
ecj-12310	45	17	lowers	lower	VERB
ecj-12310	45	18	icp	icp	PROPN
ecj-12310	45	19	.	.	PUNCT
ecj-12310	46	1	meanwhile	meanwhile	ADV
ecj-12310	46	2	,	,	PUNCT
ecj-12310	46	3	mannitol	mannitol	NOUN
ecj-12310	46	4	causes	cause	VERB
ecj-12310	46	5	a	a	DET
ecj-12310	46	6	rise	rise	NOUN
ecj-12310	46	7	in	in	ADP
ecj-12310	46	8	intravascular	intravascular	ADJ
ecj-12310	46	9	osmotic	osmotic	ADJ
ecj-12310	46	10	pressure	pressure	NOUN
ecj-12310	46	11	,	,	PUNCT
ecj-12310	46	12	widening	widen	VERB
ecj-12310	46	13	the	the	DET
ecj-12310	46	14	osmotic	osmotic	ADJ
ecj-12310	46	15	gradient	gradient	NOUN
ecj-12310	46	16	between	between	ADP
ecj-12310	46	17	the	the	DET
ecj-12310	46	18	intravascular	intravascular	ADJ
ecj-12310	46	19	and	and	CCONJ
ecj-12310	46	20	extravascular	extravascular	ADJ
ecj-12310	46	21	compartments	compartment	NOUN
ecj-12310	46	22	due	due	ADP
ecj-12310	46	23	to	to	ADP
ecj-12310	46	24	its	its	PRON
ecj-12310	46	25	size	size	NOUN
ecj-12310	46	26	and	and	CCONJ
ecj-12310	46	27	difficulty	difficulty	NOUN
ecj-12310	46	28	in	in	ADP
ecj-12310	46	29	permeating	permeate	VERB
ecj-12310	46	30	through	through	ADP
ecj-12310	46	31	the	the	DET
ecj-12310	46	32	endothelium	endothelium	NOUN
ecj-12310	46	33	barrier	barrier	NOUN
ecj-12310	46	34	.	.	PUNCT
ecj-12310	47	1	the	the	DET
ecj-12310	47	2	edematous	edematous	ADJ
ecj-12310	47	3	fluid	fluid	NOUN
ecj-12310	47	4	will	will	AUX
ecj-12310	47	5	eventually	eventually	ADV
ecj-12310	47	6	be	be	AUX
ecj-12310	47	7	pushed	push	VERB
ecj-12310	47	8	into	into	ADP
ecj-12310	47	9	blood	blood	NOUN
ecj-12310	47	10	vessels	vessel	NOUN
ecj-12310	47	11	and	and	CCONJ
ecj-12310	47	12	significantly	significantly	ADV
ecj-12310	47	13	aid	aid	VERB
ecj-12310	47	14	in	in	ADP
ecj-12310	47	15	decreasing	decrease	VERB
ecj-12310	47	16	icp.16	icp.16	ADV
ecj-12310	47	17	however	however	ADV
ecj-12310	47	18	,	,	PUNCT
ecj-12310	47	19	major	major	ADJ
ecj-12310	47	20	adverse	adverse	ADJ
ecj-12310	47	21	effects	effect	NOUN
ecj-12310	47	22	are	be	AUX
ecj-12310	47	23	becoming	become	VERB
ecj-12310	47	24	more	more	ADV
ecj-12310	47	25	and	and	CCONJ
ecj-12310	47	26	more	more	ADV
ecj-12310	47	27	evident	evident	ADJ
ecj-12310	47	28	,	,	PUNCT
ecj-12310	47	29	like	like	INTJ
ecj-12310	47	30	rebound	rebound	VERB
ecj-12310	47	31	cerebral	cerebral	ADJ
ecj-12310	47	32	edema	edema	NOUN
ecj-12310	47	33	and	and	CCONJ
ecj-12310	47	34	acute	acute	ADJ
ecj-12310	47	35	renal	renal	ADJ
ecj-12310	47	36	failure	failure	NOUN
ecj-12310	47	37	.	.	PUNCT
ecj-12310	48	1	the	the	DET
ecj-12310	48	2	potential	potential	ADJ
ecj-12310	48	3	negative	negative	ADJ
ecj-12310	48	4	effects	effect	NOUN
ecj-12310	48	5	of	of	ADP
ecj-12310	48	6	the	the	DET
ecj-12310	48	7	hyperosmolar	hyperosmolar	ADJ
ecj-12310	48	8	drug	drug	NOUN
ecj-12310	48	9	are	be	AUX
ecj-12310	48	10	to	to	PART
ecj-12310	48	11	be	be	AUX
ecj-12310	48	12	taken	take	VERB
ecj-12310	48	13	into	into	ADP
ecj-12310	48	14	account	account	NOUN
ecj-12310	48	15	while	while	SCONJ
ecj-12310	48	16	deciding	decide	VERB
ecj-12310	48	17	whether	whether	SCONJ
ecj-12310	48	18	to	to	PART
ecj-12310	48	19	administer	administer	VERB
ecj-12310	48	20	it	it	PRON
ecj-12310	48	21	.	.	PUNCT
ecj-12310	49	1	strong	strong	ADJ
ecj-12310	49	2	diuretics	diuretic	NOUN
ecj-12310	49	3	like	like	ADP
ecj-12310	49	4	mannitol	mannitol	NOUN
ecj-12310	49	5	can	can	AUX
ecj-12310	49	6	increase	increase	VERB
ecj-12310	49	7	the	the	DET
ecj-12310	49	8	potential	potential	NOUN
ecj-12310	49	9	of	of	ADP
ecj-12310	49	10	injury	injury	NOUN
ecj-12310	49	11	to	to	ADP
ecj-12310	49	12	the	the	DET
ecj-12310	49	13	kidneys	kidney	NOUN
ecj-12310	49	14	in	in	ADP
ecj-12310	49	15	hypovolemic	hypovolemic	ADJ
ecj-12310	49	16	patients	patient	NOUN
ecj-12310	49	17	.	.	PUNCT
ecj-12310	50	1	mannitol	mannitol	NOUN
ecj-12310	50	2	causes	cause	VERB
ecj-12310	50	3	osmotic	osmotic	ADJ
ecj-12310	50	4	diuresis	diuresis	NOUN
ecj-12310	50	5	,	,	PUNCT
ecj-12310	50	6	the	the	DET
ecj-12310	50	7	initial	initial	ADJ
ecj-12310	50	8	quick	quick	ADJ
ecj-12310	50	9	rise	rise	NOUN
ecj-12310	50	10	in	in	ADP
ecj-12310	50	11	intravascular	intravascular	ADJ
ecj-12310	50	12	volume	volume	NOUN
ecj-12310	50	13	paradoxically	paradoxically	ADV
ecj-12310	50	14	has	have	VERB
ecj-12310	50	15	the	the	DET
ecj-12310	50	16	potential	potential	NOUN
ecj-12310	50	17	to	to	PART
ecj-12310	50	18	lead	lead	VERB
ecj-12310	50	19	to	to	ADP
ecj-12310	50	20	acute	acute	ADJ
ecj-12310	50	21	hypervolemia	hypervolemia	NOUN
ecj-12310	50	22	and	and	CCONJ
ecj-12310	50	23	,	,	PUNCT
ecj-12310	50	24	can	can	AUX
ecj-12310	50	25	cause	cause	VERB
ecj-12310	50	26	cardiac	cardiac	ADJ
ecj-12310	50	27	failure	failure	NOUN
ecj-12310	50	28	or	or	CCONJ
ecj-12310	50	29	pulmonary	pulmonary	ADJ
ecj-12310	50	30	edema	edema	NOUN
ecj-12310	50	31	in	in	ADP
ecj-12310	50	32	vulnerable	vulnerable	ADJ
ecj-12310	50	33	patients.17	patients.17	NOUN
ecj-12310	50	34	in	in	ADP
ecj-12310	50	35	the	the	DET
ecj-12310	50	36	aftermath	aftermath	NOUN
ecj-12310	50	37	of	of	ADP
ecj-12310	50	38	brain	brain	NOUN
ecj-12310	50	39	damage	damage	NOUN
ecj-12310	50	40	,	,	PUNCT
ecj-12310	50	41	mannitol	mannitol	NOUN
ecj-12310	50	42	is	be	AUX
ecj-12310	50	43	frequently	frequently	ADV
ecj-12310	50	44	administered	administer	VERB
ecj-12310	50	45	to	to	PART
ecj-12310	50	46	lower	lower	VERB
ecj-12310	50	47	elevated	elevated	ADJ
ecj-12310	50	48	intracranial	intracranial	ADJ
ecj-12310	50	49	pressure	pressure	NOUN
ecj-12310	50	50	.	.	PUNCT
ecj-12310	51	1	initially	initially	ADV
ecj-12310	51	2	,	,	PUNCT
ecj-12310	51	3	mannitol	mannitol	NOUN
ecj-12310	51	4	reduces	reduce	VERB
ecj-12310	51	5	the	the	DET
ecj-12310	51	6	swelling	swelling	NOUN
ecj-12310	51	7	,	,	PUNCT
ecj-12310	51	8	but	but	CCONJ
ecj-12310	51	9	there	there	PRON
ecj-12310	51	10	is	be	VERB
ecj-12310	51	11	proof	proof	NOUN
ecj-12310	51	12	that	that	SCONJ
ecj-12310	51	13	continued	continue	VERB
ecj-12310	51	14	use	use	NOUN
ecj-12310	51	15	over	over	ADP
ecj-12310	51	16	time	time	NOUN
ecj-12310	51	17	can	can	AUX
ecj-12310	51	18	eventually	eventually	ADV
ecj-12310	51	19	make	make	VERB
ecj-12310	51	20	the	the	DET
ecj-12310	51	21	pressure	pressure	NOUN
ecj-12310	51	22	worse	worse	ADV
ecj-12310	51	23	.	.	PUNCT
ecj-12310	52	1	when	when	SCONJ
ecj-12310	52	2	it	it	PRON
ecj-12310	52	3	comes	come	VERB
ecj-12310	52	4	to	to	ADP
ecj-12310	52	5	the	the	DET
ecj-12310	52	6	pre	pre	ADJ
ecj-12310	52	7	-	-	ADJ
ecj-12310	52	8	operative	operative	ADJ
ecj-12310	52	9	treatment	treatment	NOUN
ecj-12310	52	10	of	of	ADP
ecj-12310	52	11	patients	patient	NOUN
ecj-12310	52	12	with	with	ADP
ecj-12310	52	13	acute	acute	ADJ
ecj-12310	52	14	cerebral	cerebral	ADJ
ecj-12310	52	15	hemorrhages	hemorrhage	NOUN
ecj-12310	52	16	,	,	PUNCT
ecj-12310	52	17	high	high	ADJ
ecj-12310	52	18	-	-	PUNCT
ecj-12310	52	19	dose	dose	NOUN
ecj-12310	52	20	mannitol	mannitol	NOUN
ecj-12310	52	21	seems	seem	VERB
ecj-12310	52	22	to	to	PART
ecj-12310	52	23	be	be	AUX
ecj-12310	52	24	preferred	prefer	VERB
ecj-12310	52	25	to	to	ADP
ecj-12310	52	26	conventional	conventional	ADJ
ecj-12310	52	27	-	-	PUNCT
ecj-12310	52	28	dose	dose	NOUN
ecj-12310	52	29	mannitol	mannitol	NOUN
ecj-12310	52	30	.	.	PUNCT
ecj-12310	53	1	the	the	DET
ecj-12310	53	2	use	use	NOUN
ecj-12310	53	3	of	of	ADP
ecj-12310	53	4	mannitol	mannitol	NOUN
ecj-12310	53	5	as	as	ADP
ecj-12310	53	6	a	a	DET
ecj-12310	53	7	continuous	continuous	ADJ
ecj-12310	53	8	infusion	infusion	NOUN
ecj-12310	53	9	in	in	ADP
ecj-12310	53	10	patients	patient	NOUN
ecj-12310	53	11	with	with	ADP
ecj-12310	53	12	elevated	elevated	ADJ
ecj-12310	53	13	intracranial	intracranial	ADJ
ecj-12310	53	14	pressure	pressure	NOUN
ecj-12310	53	15	who	who	PRON
ecj-12310	53	16	do	do	AUX
ecj-12310	53	17	not	not	PART
ecj-12310	53	18	have	have	VERB
ecj-12310	53	19	an	an	DET
ecj-12310	53	20	operative	operative	ADJ
ecj-12310	53	21	cerebral	cerebral	ADJ
ecj-12310	53	22	hemorrhage	hemorrhage	NOUN
ecj-12310	53	23	is	be	AUX
ecj-12310	53	24	,	,	PUNCT
ecj-12310	53	25	however	however	ADV
ecj-12310	53	26	,	,	PUNCT
ecj-12310	53	27	not	not	PART
ecj-12310	53	28	well	well	ADV
ecj-12310	53	29	supported	support	VERB
ecj-12310	53	30	by	by	ADP
ecj-12310	53	31	the	the	DET
ecj-12310	53	32	available	available	ADJ
ecj-12310	53	33	research	research	NOUN
ecj-12310	53	34	.	.	PUNCT
ecj-12310	54	1	the	the	DET
ecj-12310	54	2	ideal	ideal	ADJ
ecj-12310	54	3	administration	administration	NOUN
ecj-12310	54	4	of	of	ADP
ecj-12310	54	5	mannitol	mannitol	NOUN
ecj-12310	54	6	after	after	ADP
ecj-12310	54	7	an	an	DET
ecj-12310	54	8	acute	acute	ADJ
ecj-12310	54	9	traumatic	traumatic	ADJ
ecj-12310	54	10	brain	brain	NOUN
ecj-12310	54	11	injury	injury	NOUN
ecj-12310	54	12	is	be	AUX
ecj-12310	54	13	still	still	ADV
ecj-12310	54	14	a	a	DET
ecj-12310	54	15	subject	subject	NOUN
ecj-12310	54	16	of	of	ADP
ecj-12310	54	17	much	much	ADJ
ecj-12310	54	18	debate	debate	NOUN
ecj-12310	54	19	.	.	PUNCT
ecj-12310	55	1	mannitol	mannitol	NOUN
ecj-12310	55	2	’s	’s	PART
ecj-12310	55	3	present	present	ADJ
ecj-12310	55	4	widespread	widespread	ADJ
ecj-12310	55	5	use	use	NOUN
ecj-12310	55	6	and	and	CCONJ
ecj-12310	55	7	the	the	DET
ecj-12310	55	8	dearth	dearth	NOUN
ecj-12310	55	9	of	of	ADP
ecj-12310	55	10	knowledge	knowledge	NOUN
ecj-12310	55	11	when	when	SCONJ
ecj-12310	55	12	compared	compare	VERB
ecj-12310	55	13	with	with	ADP
ecj-12310	55	14	other	other	ADJ
ecj-12310	55	15	medicines	medicine	NOUN
ecj-12310	55	16	that	that	PRON
ecj-12310	55	17	lower	low	ADJ
ecj-12310	55	18	intracranial	intracranial	ADJ
ecj-12310	55	19	pressure	pressure	NOUN
ecj-12310	55	20	still	still	ADV
ecj-12310	55	21	require	require	VERB
ecj-12310	55	22	appropriate	appropriate	ADJ
ecj-12310	55	23	investigation.18	investigation.18	ADJ
ecj-12310	55	24	hypertonic	hypertonic	ADJ
ecj-12310	55	25	saline	saline	NOUN
ecj-12310	55	26	to	to	PART
ecj-12310	55	27	lower	low	ADJ
ecj-12310	55	28	intracranial	intracranial	ADJ
ecj-12310	55	29	pressure	pressure	NOUN
ecj-12310	55	30	after	after	ADP
ecj-12310	55	31	traumatic	traumatic	ADJ
ecj-12310	55	32	brain	brain	NOUN
ecj-12310	55	33	injury	injury	NOUN
ecj-12310	55	34	,	,	PUNCT
ecj-12310	55	35	hypertonic	hypertonic	ADJ
ecj-12310	55	36	saline	saline	NOUN
ecj-12310	55	37	is	be	AUX
ecj-12310	55	38	utilized	utilize	VERB
ecj-12310	55	39	as	as	ADP
ecj-12310	55	40	a	a	DET
ecj-12310	55	41	hyperosmolar	hyperosmolar	ADJ
ecj-12310	55	42	treatment	treatment	NOUN
ecj-12310	55	43	.	.	PUNCT
ecj-12310	56	1	it	it	PRON
ecj-12310	56	2	is	be	AUX
ecj-12310	56	3	still	still	ADV
ecj-12310	56	4	debatable	debatable	ADJ
ecj-12310	56	5	whether	whether	SCONJ
ecj-12310	56	6	hypertonic	hypertonic	ADJ
ecj-12310	56	7	saline	saline	NOUN
ecj-12310	56	8	is	be	AUX
ecj-12310	56	9	more	more	ADV
ecj-12310	56	10	successful	successful	ADJ
ecj-12310	56	11	than	than	ADP
ecj-12310	56	12	other	other	ADJ
ecj-12310	56	13	intracranial	intracranial	ADJ
ecj-12310	56	14	pressure	pressure	NOUN
ecj-12310	56	15	-	-	PUNCT
ecj-12310	56	16	lowering	lower	VERB
ecj-12310	56	17	medications	medication	NOUN
ecj-12310	56	18	in	in	ADP
ecj-12310	56	19	the	the	DET
ecj-12310	56	20	shortand	shortand	NOUN
ecj-12310	56	21	longterm	longterm	PROPN
ecj-12310	56	22	therapy	therapy	NOUN
ecj-12310	56	23	of	of	ADP
ecj-12310	56	24	acute	acute	ADJ
ecj-12310	56	25	traumatic	traumatic	ADJ
ecj-12310	56	26	brain	brain	NOUN
ecj-12310	56	27	injury.19	injury.19	PROPN
ecj-12310	56	28	still	still	ADV
ecj-12310	56	29	,	,	PUNCT
ecj-12310	56	30	there	there	PRON
ecj-12310	56	31	are	be	VERB
ecj-12310	56	32	several	several	ADJ
ecj-12310	56	33	potential	potential	ADJ
ecj-12310	56	34	ways	way	NOUN
ecj-12310	56	35	for	for	ADP
ecj-12310	56	36	how	how	SCONJ
ecj-12310	56	37	intracranial	intracranial	ADJ
ecj-12310	56	38	hypertension	hypertension	NOUN
ecj-12310	56	39	may	may	AUX
ecj-12310	56	40	be	be	AUX
ecj-12310	56	41	treated	treat	VERB
ecj-12310	56	42	with	with	ADP
ecj-12310	56	43	hypertonic	hypertonic	ADJ
ecj-12310	56	44	saline	saline	NOUN
ecj-12310	56	45	(	(	PUNCT
ecj-12310	56	46	hs	hs	X
ecj-12310	56	47	)	)	PUNCT
ecj-12310	56	48	.	.	PUNCT
ecj-12310	57	1	by	by	ADP
ecj-12310	57	2	establishing	establish	VERB
ecj-12310	57	3	a	a	DET
ecj-12310	57	4	pressure	pressure	NOUN
ecj-12310	57	5	gradient	gradient	NOUN
ecj-12310	57	6	within	within	ADP
ecj-12310	57	7	the	the	DET
ecj-12310	57	8	intracellular	intracellular	ADJ
ecj-12310	57	9	and	and	CCONJ
ecj-12310	57	10	intravascular	intravascular	ADJ
ecj-12310	57	11	spaces	space	NOUN
ecj-12310	57	12	and	and	CCONJ
ecj-12310	57	13	by	by	ADP
ecj-12310	57	14	exhibiting	exhibit	VERB
ecj-12310	57	15	some	some	DET
ecj-12310	57	16	rheological	rheological	ADJ
ecj-12310	57	17	effects	effect	NOUN
ecj-12310	57	18	,	,	PUNCT
ecj-12310	57	19	the	the	DET
ecj-12310	57	20	hs	hs	PROPN
ecj-12310	57	21	has	have	AUX
ecj-12310	57	22	demonstrated	demonstrate	VERB
ecj-12310	57	23	a	a	DET
ecj-12310	57	24	biphasic	biphasic	ADJ
ecj-12310	57	25	reduction	reduction	NOUN
ecj-12310	57	26	in	in	ADP
ecj-12310	57	27	icp	icp	PROPN
ecj-12310	57	28	.	.	PUNCT
ecj-12310	58	1	fluid	fluid	ADJ
ecj-12310	58	2	moves	move	NOUN
ecj-12310	58	3	osmotically	osmotically	ADV
ecj-12310	58	4	from	from	ADP
ecj-12310	58	5	the	the	DET
ecj-12310	58	6	intracellular	intracellular	NOUN
ecj-12310	58	7	into	into	ADP
ecj-12310	58	8	the	the	DET
ecj-12310	58	9	interstitial	interstitial	ADJ
ecj-12310	58	10	and	and	CCONJ
ecj-12310	58	11	intravascular	intravascular	ADJ
ecj-12310	58	12	area	area	NOUN
ecj-12310	58	13	as	as	ADP
ecj-12310	58	14	a	a	DET
ecj-12310	58	15	result	result	NOUN
ecj-12310	58	16	of	of	ADP
ecj-12310	58	17	this	this	DET
ecj-12310	58	18	gradient	gradient	NOUN
ecj-12310	58	19	.	.	PUNCT
ecj-12310	59	1	the	the	DET
ecj-12310	59	2	hypertonic	hypertonic	ADJ
ecj-12310	59	3	saline	saline	NOUN
ecj-12310	59	4	administered	administer	VERB
ecj-12310	59	5	must	must	AUX
ecj-12310	59	6	remain	remain	VERB
ecj-12310	59	7	in	in	ADP
ecj-12310	59	8	the	the	DET
ecj-12310	59	9	intravascular	intravascular	ADJ
ecj-12310	59	10	area	area	NOUN
ecj-12310	59	11	and	and	CCONJ
ecj-12310	59	12	not	not	PART
ecj-12310	59	13	penetrate	penetrate	VERB
ecj-12310	59	14	the	the	DET
ecj-12310	59	15	blood	blood	NOUN
ecj-12310	59	16	-	-	PUNCT
ecj-12310	59	17	brain	brain	NOUN
ecj-12310	59	18	barrier	barrier	NOUN
ecj-12310	59	19	to	to	PART
ecj-12310	59	20	sustain	sustain	VERB
ecj-12310	59	21	this	this	DET
ecj-12310	59	22	osmotic	osmotic	ADJ
ecj-12310	59	23	gradient.20	gradient.20	PROPN
ecj-12310	59	24	hs	hs	PROPN
ecj-12310	59	25	serves	serve	VERB
ecj-12310	59	26	as	as	ADP
ecj-12310	59	27	a	a	DET
ecj-12310	59	28	plasma	plasma	NOUN
ecj-12310	59	29	volume	volume	NOUN
ecj-12310	59	30	expander	expander	NOUN
ecj-12310	59	31	and	and	CCONJ
ecj-12310	59	32	has	have	VERB
ecj-12310	59	33	an	an	DET
ecj-12310	59	34	osmotic	osmotic	ADJ
ecj-12310	59	35	impact	impact	NOUN
ecj-12310	59	36	on	on	ADP
ecj-12310	59	37	the	the	DET
ecj-12310	59	38	cerebral	cerebral	ADJ
ecj-12310	59	39	interstitium	interstitium	NOUN
ecj-12310	59	40	.	.	PUNCT
ecj-12310	60	1	there	there	PRON
ecj-12310	60	2	is	be	VERB
ecj-12310	60	3	proof	proof	NOUN
ecj-12310	60	4	that	that	SCONJ
ecj-12310	60	5	hypertonic	hypertonic	ADJ
ecj-12310	60	6	saline	saline	NOUN
ecj-12310	60	7	has	have	AUX
ecj-12310	60	8	neurohumoral	neurohumoral	ADJ
ecj-12310	60	9	and	and	CCONJ
ecj-12310	60	10	vasoregulatory	vasoregulatory	ADJ
ecj-12310	60	11	effects	effect	NOUN
ecj-12310	60	12	as	as	ADV
ecj-12310	60	13	well	well	ADV
ecj-12310	60	14	.	.	PUNCT
ecj-12310	61	1	in	in	ADP
ecj-12310	61	2	the	the	DET
ecj-12310	61	3	context	context	NOUN
ecj-12310	61	4	of	of	ADP
ecj-12310	61	5	vasospasm	vasospasm	NOUN
ecj-12310	61	6	,	,	PUNCT
ecj-12310	61	7	it	it	PRON
ecj-12310	61	8	may	may	AUX
ecj-12310	61	9	also	also	ADV
ecj-12310	61	10	operate	operate	VERB
ecj-12310	61	11	as	as	ADP
ecj-12310	61	12	a	a	DET
ecj-12310	61	13	cerebral	cerebral	ADJ
ecj-12310	61	14	vasodilator.21	vasodilator.21	NOUN
ecj-12310	61	15	with	with	ADP
ecj-12310	61	16	the	the	DET
ecj-12310	61	17	administration	administration	NOUN
ecj-12310	61	18	of	of	ADP
ecj-12310	61	19	hts	hts	PROPN
ecj-12310	61	20	,	,	PUNCT
ecj-12310	61	21	icp	icp	PROPN
ecj-12310	61	22	reduction	reduction	NOUN
ecj-12310	61	23	is	be	AUX
ecj-12310	61	24	safe	safe	ADJ
ecj-12310	61	25	to	to	PART
ecj-12310	61	26	achieve	achieve	VERB
ecj-12310	61	27	.	.	PUNCT
ecj-12310	62	1	in	in	ADP
ecj-12310	62	2	those	those	PRON
ecj-12310	62	3	who	who	PRON
ecj-12310	62	4	have	have	VERB
ecj-12310	62	5	therapyresistant	therapyresistant	ADJ
ecj-12310	62	6	rise	rise	NOUN
ecj-12310	62	7	of	of	ADP
ecj-12310	62	8	icp	icp	PROPN
ecj-12310	62	9	,	,	PUNCT
ecj-12310	62	10	repeated	repeat	VERB
ecj-12310	62	11	bolus	bolus	ADJ
ecj-12310	62	12	administration	administration	NOUN
ecj-12310	62	13	of	of	ADP
ecj-12310	62	14	hts	hts	PROPN
ecj-12310	62	15	may	may	AUX
ecj-12310	62	16	result	result	VERB
ecj-12310	62	17	in	in	ADP
ecj-12310	62	18	a	a	DET
ecj-12310	62	19	considerable	considerable	ADJ
ecj-12310	62	20	reduction	reduction	NOUN
ecj-12310	62	21	in	in	ADP
ecj-12310	62	22	icp	icp	PROPN
ecj-12310	62	23	.	.	PUNCT
ecj-12310	63	1	a	a	DET
ecj-12310	63	2	proper	proper	ADJ
ecj-12310	63	3	icp	icp	PROPN
ecj-12310	63	4	reduction	reduction	NOUN
ecj-12310	63	5	can	can	AUX
ecj-12310	63	6	prevent	prevent	VERB
ecj-12310	63	7	subsequent	subsequent	ADJ
ecj-12310	63	8	damage	damage	NOUN
ecj-12310	63	9	and	and	CCONJ
ecj-12310	63	10	potentially	potentially	ADV
ecj-12310	63	11	life	life	NOUN
ecj-12310	63	12	-	-	PUNCT
ecj-12310	63	13	threatening	threaten	VERB
ecj-12310	63	14	consequences.22	consequences.22	NOUN
ecj-12310	63	15	when	when	SCONJ
ecj-12310	63	16	utilized	utilize	VERB
ecj-12310	63	17	for	for	ADP
ecj-12310	63	18	patients	patient	NOUN
ecj-12310	63	19	with	with	ADP
ecj-12310	63	20	head	head	NOUN
ecj-12310	63	21	injuries	injury	NOUN
ecj-12310	63	22	compounded	compound	VERB
ecj-12310	63	23	by	by	ADP
ecj-12310	63	24	hemorrhagic	hemorrhagic	NOUN
ecj-12310	63	25	shock	shock	NOUN
ecj-12310	63	26	,	,	PUNCT
ecj-12310	63	27	the	the	DET
ecj-12310	63	28	benefit	benefit	NOUN
ecj-12310	63	29	of	of	ADP
ecj-12310	63	30	improved	improved	ADJ
ecj-12310	63	31	survival	survival	NOUN
ecj-12310	63	32	was	be	AUX
ecj-12310	63	33	noted	note	VERB
ecj-12310	63	34	,	,	PUNCT
ecj-12310	63	35	leading	lead	VERB
ecj-12310	63	36	to	to	ADP
ecj-12310	63	37	the	the	DET
ecj-12310	63	38	initial	initial	ADJ
ecj-12310	63	39	recognition	recognition	NOUN
ecj-12310	63	40	of	of	ADP
ecj-12310	63	41	hts	hts	PROPN
ecj-12310	63	42	as	as	ADP
ecj-12310	63	43	a	a	DET
ecj-12310	63	44	potentially	potentially	ADV
ecj-12310	63	45	more	more	ADV
ecj-12310	63	46	successful	successful	ADJ
ecj-12310	63	47	alternative	alternative	NOUN
ecj-12310	63	48	for	for	ADP
ecj-12310	63	49	hemorrhagic	hemorrhagic	NOUN
ecj-12310	63	50	shock	shock	NOUN
ecj-12310	63	51	resuscitation	resuscitation	NOUN
ecj-12310	63	52	.	.	PUNCT
ecj-12310	64	1	hts	hts	PROPN
ecj-12310	64	2	is	be	AUX
ecj-12310	64	3	typically	typically	ADV
ecj-12310	64	4	administered	administer	VERB
ecj-12310	64	5	as	as	ADP
ecj-12310	64	6	a	a	DET
ecj-12310	64	7	bolus	bolus	ADJ
ecj-12310	64	8	or	or	CCONJ
ecj-12310	64	9	continuous	continuous	ADJ
ecj-12310	64	10	infusion	infusion	NOUN
ecj-12310	64	11	at	at	ADP
ecj-12310	64	12	dosages	dosage	NOUN
ecj-12310	64	13	of	of	ADP
ecj-12310	64	14	1.0	1.0	NUM
ecj-12310	64	15	to	to	PART
ecj-12310	64	16	4.0	4.0	NUM
ecj-12310	64	17	ml	ml	NOUN
ecj-12310	64	18	/	/	SYM
ecj-12310	64	19	kg	kg	PROPN
ecj-12310	64	20	,	,	PUNCT
ecj-12310	64	21	with	with	SCONJ
ecj-12310	64	22	a	a	DET
ecj-12310	64	23	concentration	concentration	NOUN
ecj-12310	64	24	range	range	NOUN
ecj-12310	64	25	of	of	ADP
ecj-12310	64	26	3.0	3.0	NUM
ecj-12310	64	27	%	%	NOUN
ecj-12310	64	28	to	to	ADP
ecj-12310	64	29	23.4%.23	23.4%.23	NUM
ecj-12310	64	30	the	the	DET
ecj-12310	64	31	administration	administration	NOUN
ecj-12310	64	32	of	of	ADP
ecj-12310	64	33	hs	hs	PROPN
ecj-12310	64	34	needs	need	VERB
ecj-12310	64	35	to	to	PART
ecj-12310	64	36	be	be	AUX
ecj-12310	64	37	taken	take	VERB
ecj-12310	64	38	into	into	ADP
ecj-12310	64	39	account	account	NOUN
ecj-12310	64	40	,	,	PUNCT
ecj-12310	64	41	it	it	PRON
ecj-12310	64	42	may	may	AUX
ecj-12310	64	43	result	result	VERB
ecj-12310	64	44	in	in	ADP
ecj-12310	64	45	demyelination	demyelination	NOUN
ecj-12310	64	46	syndrome	syndrome	NOUN
ecj-12310	64	47	in	in	ADP
ecj-12310	64	48	patients	patient	NOUN
ecj-12310	64	49	with	with	ADP
ecj-12310	64	50	a	a	DET
ecj-12310	64	51	chronic	chronic	ADJ
ecj-12310	64	52	condition	condition	NOUN
ecj-12310	64	53	of	of	ADP
ecj-12310	64	54	hypernatremia	hypernatremia	NOUN
ecj-12310	64	55	and	and	CCONJ
ecj-12310	64	56	hyponatremia.24	hyponatremia.24	VERB
ecj-12310	64	57	to	to	PART
ecj-12310	64	58	prevent	prevent	VERB
ecj-12310	64	59	the	the	DET
ecj-12310	64	60	negative	negative	ADJ
ecj-12310	64	61	effects	effect	NOUN
ecj-12310	64	62	,	,	PUNCT
ecj-12310	64	63	a	a	DET
ecj-12310	64	64	periodic	periodic	ADJ
ecj-12310	64	65	electrolyte	electrolyte	NOUN
ecj-12310	64	66	serum	serum	NOUN
ecj-12310	64	67	check	check	NOUN
ecj-12310	64	68	may	may	AUX
ecj-12310	64	69	be	be	AUX
ecj-12310	64	70	required	require	VERB
ecj-12310	64	71	.	.	PUNCT
ecj-12310	65	1	because	because	SCONJ
ecj-12310	65	2	hs	hs	PROPN
ecj-12310	65	3	has	have	VERB
ecj-12310	65	4	a	a	DET
ecj-12310	65	5	higher	high	ADJ
ecj-12310	65	6	coefficient	coefficient	NOUN
ecj-12310	65	7	to	to	PART
ecj-12310	65	8	cross	cross	VERB
ecj-12310	65	9	the	the	DET
ecj-12310	65	10	brain	brain	NOUN
ecj-12310	65	11	review	review	NOUN
ecj-12310	65	12	[	[	X
ecj-12310	65	13	emergency	emergency	NOUN
ecj-12310	65	14	care	care	NOUN
ecj-12310	65	15	journal	journal	PROPN
ecj-12310	65	16	2024	2024	NUM
ecj-12310	65	17	;	;	PUNCT
ecj-12310	65	18	20:12310	20:12310	NUM
ecj-12310	65	19	]	]	X
ecj-12310	66	1	[	[	X
ecj-12310	66	2	page	page	NOUN
ecj-12310	66	3	32	32	NUM
ecj-12310	66	4	]	]	PUNCT
ecj-12310	66	5	non	non	ADJ
ecj-12310	66	6	-co	-co	PROPN
ecj-12310	66	7	mmerc	mmerc	PROPN
ecj-12310	66	8	ial	ial	PROPN
ecj-12310	66	9	us	us	PROPN
ecj-12310	66	10	e	e	NOUN
ecj-12310	66	11	o	o	NOUN
ecj-12310	66	12	nly	nly	ADV
ecj-12310	66	13	barrier	barrier	NOUN
ecj-12310	66	14	than	than	ADP
ecj-12310	66	15	mannitol	mannitol	NOUN
ecj-12310	66	16	,	,	PUNCT
ecj-12310	66	17	the	the	DET
ecj-12310	66	18	rebound	rebound	NOUN
ecj-12310	66	19	phenomenon	phenomenon	NOUN
ecj-12310	66	20	is	be	AUX
ecj-12310	66	21	less	less	ADV
ecj-12310	66	22	frequent	frequent	ADJ
ecj-12310	66	23	when	when	SCONJ
ecj-12310	66	24	administered	administer	VERB
ecj-12310	66	25	with	with	ADP
ecj-12310	66	26	hs.21	hs.21	ADJ
ecj-12310	66	27	intracranial	intracranial	ADJ
ecj-12310	66	28	pressure	pressure	NOUN
ecj-12310	66	29	monitoring	monitoring	NOUN
ecj-12310	66	30	for	for	ADP
ecj-12310	66	31	most	most	ADJ
ecj-12310	66	32	healthcare	healthcare	NOUN
ecj-12310	66	33	workers	worker	NOUN
ecj-12310	66	34	,	,	PUNCT
ecj-12310	66	35	including	include	VERB
ecj-12310	66	36	neurological	neurological	ADJ
ecj-12310	66	37	surgeons	surgeon	NOUN
ecj-12310	66	38	and	and	CCONJ
ecj-12310	66	39	physicians	physician	NOUN
ecj-12310	66	40	,	,	PUNCT
ecj-12310	66	41	icp	icp	PROPN
ecj-12310	66	42	is	be	AUX
ecj-12310	66	43	equivalent	equivalent	ADJ
ecj-12310	66	44	to	to	ADP
ecj-12310	66	45	a	a	DET
ecj-12310	66	46	numerical	numerical	ADJ
ecj-12310	66	47	figure	figure	NOUN
ecj-12310	66	48	.	.	PUNCT
ecj-12310	67	1	it	it	PRON
ecj-12310	67	2	might	might	AUX
ecj-12310	67	3	be	be	AUX
ecj-12310	67	4	the	the	DET
ecj-12310	67	5	amount	amount	NOUN
ecj-12310	67	6	of	of	ADP
ecj-12310	67	7	fluid	fluid	NOUN
ecj-12310	67	8	in	in	ADP
ecj-12310	67	9	an	an	DET
ecj-12310	67	10	irrigation	irrigation	NOUN
ecj-12310	67	11	system	system	NOUN
ecj-12310	67	12	or	or	CCONJ
ecj-12310	67	13	the	the	DET
ecj-12310	67	14	value	value	NOUN
ecj-12310	67	15	displayed	display	VERB
ecj-12310	67	16	on	on	ADP
ecj-12310	67	17	the	the	DET
ecj-12310	67	18	display	display	NOUN
ecj-12310	67	19	of	of	ADP
ecj-12310	67	20	the	the	DET
ecj-12310	67	21	computer	computer	NOUN
ecj-12310	67	22	in	in	ADP
ecj-12310	67	23	millimeters	millimeter	NOUN
ecj-12310	67	24	of	of	ADP
ecj-12310	67	25	mercury	mercury	NOUN
ecj-12310	67	26	(	(	PUNCT
ecj-12310	67	27	mmhg).25	mmhg).25	X
ecj-12310	67	28	icp	icp	PROPN
ecj-12310	67	29	is	be	AUX
ecj-12310	67	30	much	much	ADV
ecj-12310	67	31	more	more	ADJ
ecj-12310	67	32	than	than	ADP
ecj-12310	67	33	just	just	ADV
ecj-12310	67	34	a	a	DET
ecj-12310	67	35	number	number	NOUN
ecj-12310	67	36	.	.	PUNCT
ecj-12310	68	1	to	to	PART
ecj-12310	68	2	enhance	enhance	VERB
ecj-12310	68	3	clinical	clinical	ADJ
ecj-12310	68	4	decision	decision	NOUN
ecj-12310	68	5	-	-	PUNCT
ecj-12310	68	6	making	making	NOUN
ecj-12310	68	7	,	,	PUNCT
ecj-12310	68	8	a	a	DET
ecj-12310	68	9	variety	variety	NOUN
ecj-12310	68	10	of	of	ADP
ecj-12310	68	11	icp	icp	PROPN
ecj-12310	68	12	ratings	rating	NOUN
ecj-12310	68	13	and	and	CCONJ
ecj-12310	68	14	icp	icp	NOUN
ecj-12310	68	15	-	-	PUNCT
ecj-12310	68	16	derived	derive	VERB
ecj-12310	68	17	assessments	assessment	NOUN
ecj-12310	68	18	have	have	AUX
ecj-12310	68	19	been	be	AUX
ecj-12310	68	20	investigated.26	investigated.26	ADJ
ecj-12310	68	21	normal	normal	ADJ
ecj-12310	68	22	mean	mean	NOUN
ecj-12310	68	23	icp	icp	PROPN
ecj-12310	68	24	readings	reading	NOUN
ecj-12310	68	25	have	have	AUX
ecj-12310	68	26	not	not	PART
ecj-12310	68	27	been	be	AUX
ecj-12310	68	28	determined	determine	VERB
ecj-12310	68	29	since	since	SCONJ
ecj-12310	68	30	icp	icp	PROPN
ecj-12310	68	31	assessments	assessment	NOUN
ecj-12310	68	32	in	in	ADP
ecj-12310	68	33	individuals	individual	NOUN
ecj-12310	68	34	in	in	ADP
ecj-12310	68	35	good	good	ADJ
ecj-12310	68	36	health	health	NOUN
ecj-12310	68	37	can	can	AUX
ecj-12310	68	38	not	not	PART
ecj-12310	68	39	be	be	AUX
ecj-12310	68	40	justified	justify	VERB
ecj-12310	68	41	ethically	ethically	ADV
ecj-12310	68	42	.	.	PUNCT
ecj-12310	69	1	only	only	ADV
ecj-12310	69	2	indirect	indirect	ADJ
ecj-12310	69	3	evidence	evidence	NOUN
ecj-12310	69	4	concerning	concern	VERB
ecj-12310	69	5	icp	icp	PROPN
ecj-12310	69	6	from	from	ADP
ecj-12310	69	7	people	people	NOUN
ecj-12310	69	8	who	who	PRON
ecj-12310	69	9	are	be	AUX
ecj-12310	69	10	“	"	PUNCT
ecj-12310	69	11	as	as	ADV
ecj-12310	69	12	normal	normal	ADJ
ecj-12310	69	13	as	as	ADP
ecj-12310	69	14	possible	possible	ADJ
ecj-12310	69	15	”	"	PUNCT
ecj-12310	69	16	is	be	AUX
ecj-12310	69	17	available	available	ADJ
ecj-12310	69	18	.	.	PUNCT
ecj-12310	70	1	the	the	DET
ecj-12310	70	2	aim	aim	NOUN
ecj-12310	70	3	,	,	PUNCT
ecj-12310	70	4	by	by	ADP
ecj-12310	70	5	tbi	tbi	PROPN
ecj-12310	70	6	guidelines	guideline	NOUN
ecj-12310	70	7	,	,	PUNCT
ecj-12310	70	8	is	be	AUX
ecj-12310	70	9	to	to	PART
ecj-12310	70	10	keep	keep	VERB
ecj-12310	70	11	mean	mean	VERB
ecj-12310	70	12	icp	icp	PROPN
ecj-12310	70	13	under	under	ADP
ecj-12310	70	14	20	20	NUM
ecj-12310	70	15	mmhg.27	mmhg.27	NOUN
ecj-12310	70	16	the	the	DET
ecj-12310	70	17	mean	mean	NOUN
ecj-12310	70	18	icp	icp	PROPN
ecj-12310	70	19	values	value	NOUN
ecj-12310	70	20	do	do	AUX
ecj-12310	70	21	n’t	not	PART
ecj-12310	70	22	seem	seem	VERB
ecj-12310	70	23	to	to	PART
ecj-12310	70	24	alter	alter	VERB
ecj-12310	70	25	between	between	ADP
ecj-12310	70	26	the	the	DET
ecj-12310	70	27	hours	hour	NOUN
ecj-12310	70	28	of	of	ADP
ecj-12310	70	29	day	day	NOUN
ecj-12310	70	30	and	and	CCONJ
ecj-12310	70	31	night.28	night.28	NOUN
ecj-12310	70	32	the	the	DET
ecj-12310	70	33	average	average	ADJ
ecj-12310	70	34	mean	mean	NOUN
ecj-12310	70	35	icp	icp	PROPN
ecj-12310	70	36	values	value	NOUN
ecj-12310	70	37	,	,	PUNCT
ecj-12310	70	38	on	on	ADP
ecj-12310	70	39	the	the	DET
ecj-12310	70	40	other	other	ADJ
ecj-12310	70	41	hand	hand	NOUN
ecj-12310	70	42	,	,	PUNCT
ecj-12310	70	43	are	be	AUX
ecj-12310	70	44	significantly	significantly	ADV
ecj-12310	70	45	dependent	dependent	ADJ
ecj-12310	70	46	on	on	ADP
ecj-12310	70	47	body	body	NOUN
ecj-12310	70	48	posture	posture	NOUN
ecj-12310	70	49	.	.	PUNCT
ecj-12310	71	1	the	the	DET
ecj-12310	71	2	mean	mean	PROPN
ecj-12310	71	3	icp	icp	PROPN
ecj-12310	71	4	decreases	decrease	VERB
ecj-12310	71	5	when	when	SCONJ
ecj-12310	71	6	a	a	DET
ecj-12310	71	7	person	person	NOUN
ecj-12310	71	8	stands	stand	VERB
ecj-12310	71	9	up	up	ADP
ecj-12310	71	10	straight	straight	ADV
ecj-12310	71	11	.	.	PUNCT
ecj-12310	72	1	reported	report	VERB
ecj-12310	72	2	that	that	SCONJ
ecj-12310	72	3	the	the	DET
ecj-12310	72	4	positional	positional	ADJ
ecj-12310	72	5	variation	variation	NOUN
ecj-12310	72	6	in	in	ADP
ecj-12310	72	7	mean	mean	PROPN
ecj-12310	72	8	icp	icp	PROPN
ecj-12310	72	9	might	might	AUX
ecj-12310	72	10	distinguish	distinguish	VERB
ecj-12310	72	11	healthy	healthy	ADJ
ecj-12310	72	12	persons	person	NOUN
ecj-12310	72	13	from	from	ADP
ecj-12310	72	14	csf	csf	ADJ
ecj-12310	72	15	disturbance	disturbance	NOUN
ecj-12310	72	16	patients	patient	NOUN
ecj-12310	72	17	.	.	PUNCT
ecj-12310	73	1	in	in	ADP
ecj-12310	73	2	our	our	PRON
ecj-12310	73	3	clinical	clinical	ADJ
ecj-12310	73	4	practice	practice	NOUN
ecj-12310	73	5	,	,	PUNCT
ecj-12310	73	6	mean	mean	VERB
ecj-12310	73	7	icp	icp	PROPN
ecj-12310	73	8	in	in	ADP
ecj-12310	73	9	a	a	DET
ecj-12310	73	10	standing	stand	VERB
ecj-12310	73	11	position	position	NOUN
ecj-12310	73	12	of	of	ADP
ecj-12310	73	13	less	less	ADJ
ecj-12310	73	14	than	than	ADP
ecj-12310	73	15	5	5	NUM
ecj-12310	73	16	mmhg	mmhg	NOUN
ecj-12310	73	17	is	be	AUX
ecj-12310	73	18	considered	consider	VERB
ecj-12310	73	19	abnormal.29,30	abnormal.29,30	NOUN
ecj-12310	73	20	to	to	PART
ecj-12310	73	21	add	add	VERB
ecj-12310	73	22	clinical	clinical	ADJ
ecj-12310	73	23	significance	significance	NOUN
ecj-12310	73	24	to	to	PART
ecj-12310	73	25	mean	mean	VERB
ecj-12310	73	26	icp	icp	PROPN
ecj-12310	73	27	alone	alone	ADV
ecj-12310	73	28	,	,	PUNCT
ecj-12310	73	29	it	it	PRON
ecj-12310	73	30	has	have	AUX
ecj-12310	73	31	been	be	AUX
ecj-12310	73	32	coupled	couple	VERB
ecj-12310	73	33	with	with	ADP
ecj-12310	73	34	additional	additional	ADJ
ecj-12310	73	35	variables	variable	NOUN
ecj-12310	73	36	to	to	PART
ecj-12310	73	37	form	form	VERB
ecj-12310	73	38	multiple	multiple	ADJ
ecj-12310	73	39	indices	index	NOUN
ecj-12310	73	40	.	.	PUNCT
ecj-12310	74	1	cpp	cpp	NOUN
ecj-12310	74	2	,	,	PUNCT
ecj-12310	74	3	which	which	PRON
ecj-12310	74	4	is	be	AUX
ecj-12310	74	5	the	the	DET
ecj-12310	74	6	variation	variation	NOUN
ecj-12310	74	7	between	between	ADP
ecj-12310	74	8	average	average	ADJ
ecj-12310	74	9	arterial	arterial	ADJ
ecj-12310	74	10	bp	bp	PROPN
ecj-12310	74	11	and	and	CCONJ
ecj-12310	74	12	average	average	ADJ
ecj-12310	74	13	icp	icp	PROPN
ecj-12310	74	14	(	(	PUNCT
ecj-12310	74	15	cpp	cpp	NOUN
ecj-12310	74	16	=	=	NOUN
ecj-12310	74	17	mean	mean	PROPN
ecj-12310	74	18	arterial	arterial	ADJ
ecj-12310	74	19	bp	bp	PROPN
ecj-12310	74	20	-	-	PUNCT
ecj-12310	74	21	mean	mean	PROPN
ecj-12310	74	22	icp	icp	PROPN
ecj-12310	74	23	)	)	PUNCT
ecj-12310	74	24	,	,	PUNCT
ecj-12310	74	25	is	be	AUX
ecj-12310	74	26	probably	probably	ADV
ecj-12310	74	27	the	the	DET
ecj-12310	74	28	most	most	ADV
ecj-12310	74	29	well	well	ADV
ecj-12310	74	30	-	-	PUNCT
ecj-12310	74	31	known	know	VERB
ecj-12310	74	32	icp	icp	NOUN
ecj-12310	74	33	-	-	PUNCT
ecj-12310	74	34	derived	derive	VERB
ecj-12310	74	35	measure.31	measure.31	NOUN
ecj-12310	74	36	other	other	ADJ
ecj-12310	74	37	indicators	indicator	NOUN
ecj-12310	74	38	employed	employ	VERB
ecj-12310	74	39	in	in	ADP
ecj-12310	74	40	certain	certain	ADJ
ecj-12310	74	41	centers	center	NOUN
ecj-12310	74	42	include	include	VERB
ecj-12310	74	43	the	the	DET
ecj-12310	74	44	rap	rap	NOUN
ecj-12310	74	45	,	,	PUNCT
ecj-12310	74	46	which	which	PRON
ecj-12310	74	47	stands	stand	VERB
ecj-12310	74	48	for	for	ADP
ecj-12310	74	49	the	the	DET
ecj-12310	74	50	relationship	relationship	NOUN
ecj-12310	74	51	between	between	ADP
ecj-12310	74	52	amplitude	amplitude	NOUN
ecj-12310	74	53	and	and	CCONJ
ecj-12310	74	54	pressure	pressure	NOUN
ecj-12310	74	55	,	,	PUNCT
ecj-12310	74	56	and	and	CCONJ
ecj-12310	74	57	the	the	DET
ecj-12310	74	58	pressure	pressure	NOUN
ecj-12310	74	59	reactivity	reactivity	NOUN
ecj-12310	74	60	index(prx).32	index(prx).32	PUNCT
ecj-12310	74	61	a	a	DET
ecj-12310	74	62	rap	rap	NOUN
ecj-12310	74	63	greater	great	ADJ
ecj-12310	74	64	than	than	ADP
ecj-12310	74	65	0.6	0.6	NUM
ecj-12310	74	66	has	have	AUX
ecj-12310	74	67	been	be	AUX
ecj-12310	74	68	regarded	regard	VERB
ecj-12310	74	69	as	as	ADP
ecj-12310	74	70	indicating	indicate	VERB
ecj-12310	74	71	a	a	DET
ecj-12310	74	72	deteriorated	deteriorated	ADJ
ecj-12310	74	73	pressure	pressure	NOUN
ecj-12310	74	74	-	-	PUNCT
ecj-12310	74	75	volume	volume	NOUN
ecj-12310	74	76	reserve.33	reserve.33	NOUN
ecj-12310	74	77	the	the	DET
ecj-12310	74	78	prx	prx	PROPN
ecj-12310	74	79	(	(	PUNCT
ecj-12310	74	80	moving	move	VERB
ecj-12310	74	81	association	association	NOUN
ecj-12310	74	82	of	of	ADP
ecj-12310	74	83	average	average	ADJ
ecj-12310	74	84	icp	icp	PROPN
ecj-12310	74	85	and	and	CCONJ
ecj-12310	74	86	average	average	ADJ
ecj-12310	74	87	arterial	arterial	ADJ
ecj-12310	74	88	bp	bp	PROPN
ecj-12310	74	89	)	)	PUNCT
ecj-12310	74	90	is	be	AUX
ecj-12310	74	91	thought	think	VERB
ecj-12310	74	92	to	to	PART
ecj-12310	74	93	be	be	AUX
ecj-12310	74	94	an	an	DET
ecj-12310	74	95	indicator	indicator	NOUN
ecj-12310	74	96	of	of	ADP
ecj-12310	74	97	auto	auto	NOUN
ecj-12310	74	98	-	-	PUNCT
ecj-12310	74	99	regulatory	regulatory	ADJ
ecj-12310	74	100	status	status	NOUN
ecj-12310	74	101	or	or	CCONJ
ecj-12310	74	102	a	a	DET
ecj-12310	74	103	measure	measure	NOUN
ecj-12310	74	104	of	of	ADP
ecj-12310	74	105	cerebrovascular	cerebrovascular	ADJ
ecj-12310	74	106	responsiveness.34	responsiveness.34	NOUN
ecj-12310	74	107	hyponatremia	hyponatremia	NOUN
ecj-12310	74	108	:	:	PUNCT
ecj-12310	74	109	an	an	DET
ecj-12310	74	110	emergency	emergency	NOUN
ecj-12310	74	111	in	in	ADP
ecj-12310	74	112	traumatic	traumatic	ADJ
ecj-12310	74	113	brain	brain	NOUN
ecj-12310	74	114	injury	injury	NOUN
ecj-12310	74	115	the	the	DET
ecj-12310	74	116	primary	primary	ADJ
ecj-12310	74	117	electrolyte	electrolyte	NOUN
ecj-12310	74	118	imbalance	imbalance	NOUN
ecj-12310	74	119	seen	see	VERB
ecj-12310	74	120	in	in	ADP
ecj-12310	74	121	individuals	individual	NOUN
ecj-12310	74	122	with	with	ADP
ecj-12310	74	123	tbi	tbi	PROPN
ecj-12310	74	124	is	be	AUX
ecj-12310	74	125	hyponatremia	hyponatremia	ADJ
ecj-12310	74	126	and	and	CCONJ
ecj-12310	74	127	is	be	AUX
ecj-12310	74	128	considered	consider	VERB
ecj-12310	74	129	as	as	ADP
ecj-12310	74	130	most	most	ADJ
ecj-12310	74	131	emergency	emergency	NOUN
ecj-12310	74	132	,	,	PUNCT
ecj-12310	74	133	which	which	PRON
ecj-12310	74	134	is	be	AUX
ecj-12310	74	135	defined	define	VERB
ecj-12310	74	136	as	as	ADP
ecj-12310	74	137	serum	serum	NOUN
ecj-12310	74	138	sodium	sodium	NOUN
ecj-12310	74	139	<	<	X
ecj-12310	74	140	135	135	NUM
ecj-12310	74	141	meq	meq	NOUN
ecj-12310	74	142	/	/	SYM
ecj-12310	74	143	l.	l.	PROPN
ecj-12310	74	144	hyponatremia	hyponatremia	PROPN
ecj-12310	74	145	has	have	AUX
ecj-12310	74	146	been	be	AUX
ecj-12310	74	147	documented	document	VERB
ecj-12310	74	148	to	to	PART
ecj-12310	74	149	occur	occur	VERB
ecj-12310	74	150	in	in	ADP
ecj-12310	74	151	9.6	9.6	NUM
ecj-12310	74	152	%	%	NOUN
ecj-12310	74	153	to	to	PART
ecj-12310	74	154	51	51	NUM
ecj-12310	74	155	%	%	NOUN
ecj-12310	74	156	of	of	ADP
ecj-12310	74	157	tbi	tbi	NOUN
ecj-12310	74	158	patients	patient	NOUN
ecj-12310	74	159	,	,	PUNCT
ecj-12310	74	160	and	and	CCONJ
ecj-12310	74	161	it	it	PRON
ecj-12310	74	162	is	be	AUX
ecj-12310	74	163	well	well	ADV
ecj-12310	74	164	-	-	PUNCT
ecj-12310	74	165	known	know	VERB
ecj-12310	74	166	that	that	SCONJ
ecj-12310	74	167	hyponatremia	hyponatremia	PROPN
ecj-12310	74	168	independently	independently	ADV
ecj-12310	74	169	predicts	predict	VERB
ecj-12310	74	170	a	a	DET
ecj-12310	74	171	poor	poor	ADJ
ecj-12310	74	172	neurologic	neurologic	ADJ
ecj-12310	74	173	prognosis	prognosis	NOUN
ecj-12310	74	174	in	in	ADP
ecj-12310	74	175	tbi	tbi	NOUN
ecj-12310	74	176	patients	patient	NOUN
ecj-12310	74	177	.	.	PUNCT
ecj-12310	75	1	the	the	DET
ecj-12310	75	2	syndrome	syndrome	NOUN
ecj-12310	75	3	of	of	ADP
ecj-12310	75	4	inappropriate	inappropriate	ADJ
ecj-12310	75	5	antidiuretic	antidiuretic	ADJ
ecj-12310	75	6	hormone	hormone	NOUN
ecj-12310	75	7	secretion	secretion	NOUN
ecj-12310	75	8	(	(	PUNCT
ecj-12310	75	9	siadh	siadh	NOUN
ecj-12310	75	10	)	)	PUNCT
ecj-12310	75	11	,	,	PUNCT
ecj-12310	75	12	hypopituitarism	hypopituitarism	NOUN
ecj-12310	75	13	,	,	PUNCT
ecj-12310	75	14	cerebral	cerebral	ADJ
ecj-12310	75	15	salt	salt	NOUN
ecj-12310	75	16	wasting	waste	VERB
ecj-12310	75	17	syndrome	syndrome	NOUN
ecj-12310	75	18	(	(	PUNCT
ecj-12310	75	19	csw	csw	PROPN
ecj-12310	75	20	)	)	PUNCT
ecj-12310	75	21	,	,	PUNCT
ecj-12310	75	22	and	and	CCONJ
ecj-12310	75	23	insufficient	insufficient	ADJ
ecj-12310	75	24	salt	salt	NOUN
ecj-12310	75	25	consumption	consumption	NOUN
ecj-12310	75	26	in	in	ADP
ecj-12310	75	27	the	the	DET
ecj-12310	75	28	diet	diet	NOUN
ecj-12310	75	29	are	be	AUX
ecj-12310	75	30	the	the	DET
ecj-12310	75	31	major	major	ADJ
ecj-12310	75	32	causes	cause	NOUN
ecj-12310	75	33	of	of	ADP
ecj-12310	75	34	hyponatremia	hyponatremia	NOUN
ecj-12310	75	35	in	in	ADP
ecj-12310	75	36	tbi	tbi	PROPN
ecj-12310	75	37	patients.35	patients.35	NOUN
ecj-12310	75	38	following	follow	VERB
ecj-12310	75	39	traumatic	traumatic	ADJ
ecj-12310	75	40	brain	brain	NOUN
ecj-12310	75	41	injury	injury	NOUN
ecj-12310	75	42	,	,	PUNCT
ecj-12310	75	43	dysregulation	dysregulation	NOUN
ecj-12310	75	44	of	of	ADP
ecj-12310	75	45	the	the	DET
ecj-12310	75	46	neuroendocrine	neuroendocrine	NOUN
ecj-12310	75	47	system	system	NOUN
ecj-12310	75	48	is	be	AUX
ecj-12310	75	49	a	a	DET
ecj-12310	75	50	common	common	ADJ
ecj-12310	75	51	consequence	consequence	NOUN
ecj-12310	75	52	(	(	PUNCT
ecj-12310	75	53	tbi	tbi	NOUN
ecj-12310	75	54	)	)	PUNCT
ecj-12310	75	55	.	.	PUNCT
ecj-12310	76	1	these	these	DET
ecj-12310	76	2	hormone	hormone	NOUN
ecj-12310	76	3	imbalances	imbalance	NOUN
ecj-12310	76	4	often	often	ADV
ecj-12310	76	5	have	have	VERB
ecj-12310	76	6	mild	mild	ADJ
ecj-12310	76	7	symptoms	symptom	NOUN
ecj-12310	76	8	that	that	PRON
ecj-12310	76	9	are	be	AUX
ecj-12310	76	10	simple	simple	ADJ
ecj-12310	76	11	to	to	PART
ecj-12310	76	12	overlook	overlook	VERB
ecj-12310	76	13	.	.	PUNCT
ecj-12310	77	1	usually	usually	ADV
ecj-12310	77	2	,	,	PUNCT
ecj-12310	77	3	hyponatremia	hyponatremia	PROPN
ecj-12310	77	4	is	be	AUX
ecj-12310	77	5	a	a	DET
ecj-12310	77	6	sign	sign	NOUN
ecj-12310	77	7	of	of	ADP
ecj-12310	77	8	underlying	underlie	VERB
ecj-12310	77	9	illnesses	illness	NOUN
ecj-12310	77	10	that	that	PRON
ecj-12310	77	11	interfere	interfere	VERB
ecj-12310	77	12	with	with	ADP
ecj-12310	77	13	fluid	fluid	ADJ
ecj-12310	77	14	homeostasis	homeostasis	NOUN
ecj-12310	77	15	.	.	PUNCT
ecj-12310	78	1	hyponatremia	hyponatremia	PROPN
ecj-12310	78	2	is	be	AUX
ecj-12310	78	3	a	a	DET
ecj-12310	78	4	characteristic	characteristic	NOUN
ecj-12310	78	5	of	of	ADP
ecj-12310	78	6	the	the	DET
ecj-12310	78	7	siadh	siadh	NOUN
ecj-12310	78	8	following	follow	VERB
ecj-12310	78	9	brain	brain	NOUN
ecj-12310	78	10	injury	injury	NOUN
ecj-12310	78	11	in	in	ADP
ecj-12310	78	12	the	the	DET
ecj-12310	78	13	majority	majority	NOUN
ecj-12310	78	14	of	of	ADP
ecj-12310	78	15	tbi	tbi	NOUN
ecj-12310	78	16	patients	patient	NOUN
ecj-12310	78	17	,	,	PUNCT
ecj-12310	78	18	which	which	PRON
ecj-12310	78	19	is	be	AUX
ecj-12310	78	20	caused	cause	VERB
ecj-12310	78	21	by	by	ADP
ecj-12310	78	22	pituitary	pituitary	ADJ
ecj-12310	78	23	failure	failure	NOUN
ecj-12310	78	24	.	.	PUNCT
ecj-12310	79	1	hyponatremia	hyponatremia	PROPN
ecj-12310	79	2	linked	link	VERB
ecj-12310	79	3	to	to	ADP
ecj-12310	79	4	traumatic	traumatic	ADJ
ecj-12310	79	5	brain	brain	NOUN
ecj-12310	79	6	injury	injury	NOUN
ecj-12310	79	7	is	be	AUX
ecj-12310	79	8	often	often	ADV
ecj-12310	79	9	temporary	temporary	ADJ
ecj-12310	79	10	and	and	CCONJ
ecj-12310	79	11	curable.36	curable.36	NOUN
ecj-12310	79	12	when	when	SCONJ
ecj-12310	79	13	mannitol	mannitol	NOUN
ecj-12310	79	14	is	be	AUX
ecj-12310	79	15	administered	administer	VERB
ecj-12310	79	16	to	to	PART
ecj-12310	79	17	reduce	reduce	VERB
ecj-12310	79	18	intracranial	intracranial	ADJ
ecj-12310	79	19	pressure	pressure	NOUN
ecj-12310	79	20	in	in	ADP
ecj-12310	79	21	traumatic	traumatic	ADJ
ecj-12310	79	22	brain	brain	NOUN
ecj-12310	79	23	injury	injury	NOUN
ecj-12310	79	24	intravascular	intravascular	ADJ
ecj-12310	79	25	free	free	ADJ
ecj-12310	79	26	water	water	NOUN
ecj-12310	79	27	content	content	NOUN
ecj-12310	79	28	is	be	AUX
ecj-12310	79	29	first	first	ADV
ecj-12310	79	30	raised	raise	VERB
ecj-12310	79	31	,	,	PUNCT
ecj-12310	79	32	which	which	PRON
ecj-12310	79	33	might	might	AUX
ecj-12310	79	34	exacerbate	exacerbate	VERB
ecj-12310	79	35	electrolyte	electrolyte	ADJ
ecj-12310	79	36	imbalances	imbalance	NOUN
ecj-12310	79	37	,	,	PUNCT
ecj-12310	79	38	such	such	ADJ
ecj-12310	79	39	as	as	ADP
ecj-12310	79	40	hyponatremia	hyponatremia	PROPN
ecj-12310	79	41	.	.	PUNCT
ecj-12310	80	1	the	the	DET
ecj-12310	80	2	second	second	ADJ
ecj-12310	80	3	phase	phase	NOUN
ecj-12310	80	4	of	of	ADP
ecj-12310	80	5	action	action	NOUN
ecj-12310	80	6	involves	involve	VERB
ecj-12310	80	7	the	the	DET
ecj-12310	80	8	excretion	excretion	NOUN
ecj-12310	80	9	of	of	ADP
ecj-12310	80	10	mannitol	mannitol	NOUN
ecj-12310	80	11	in	in	ADP
ecj-12310	80	12	the	the	DET
ecj-12310	80	13	urine	urine	NOUN
ecj-12310	80	14	together	together	ADV
ecj-12310	80	15	with	with	ADP
ecj-12310	80	16	an	an	DET
ecj-12310	80	17	excess	excess	NOUN
ecj-12310	80	18	of	of	ADP
ecj-12310	80	19	free	free	ADJ
ecj-12310	80	20	water	water	NOUN
ecj-12310	80	21	,	,	PUNCT
ecj-12310	80	22	which	which	PRON
ecj-12310	80	23	may	may	AUX
ecj-12310	80	24	lead	lead	VERB
ecj-12310	80	25	to	to	ADP
ecj-12310	80	26	hypernatremia	hypernatremia	NOUN
ecj-12310	80	27	because	because	SCONJ
ecj-12310	80	28	of	of	ADP
ecj-12310	80	29	the	the	DET
ecj-12310	80	30	induced	induced	ADJ
ecj-12310	80	31	diuresis.37	diuresis.37	NOUN
ecj-12310	80	32	mannitol	mannitol	NOUN
ecj-12310	80	33	also	also	ADV
ecj-12310	80	34	worsens	worsen	VERB
ecj-12310	80	35	the	the	DET
ecj-12310	80	36	cerebral	cerebral	ADJ
ecj-12310	80	37	edema	edema	NOUN
ecj-12310	80	38	.	.	PUNCT
ecj-12310	81	1	it	it	PRON
ecj-12310	81	2	partially	partially	ADV
ecj-12310	81	3	penetrates	penetrate	VERB
ecj-12310	81	4	the	the	DET
ecj-12310	81	5	vessel	vessel	NOUN
ecj-12310	81	6	wall	wall	NOUN
ecj-12310	81	7	,	,	PUNCT
ecj-12310	81	8	despite	despite	SCONJ
ecj-12310	81	9	its	its	PRON
ecj-12310	81	10	limited	limited	ADJ
ecj-12310	81	11	cross	cross	ADJ
ecj-12310	81	12	-	-	ADJ
ecj-12310	81	13	sectional	sectional	ADJ
ecj-12310	81	14	area	area	NOUN
ecj-12310	81	15	,	,	PUNCT
ecj-12310	81	16	in	in	ADP
ecj-12310	81	17	individuals	individual	NOUN
ecj-12310	81	18	with	with	ADP
ecj-12310	81	19	cerebral	cerebral	ADJ
ecj-12310	81	20	hemorrhage	hemorrhage	NOUN
ecj-12310	81	21	,	,	PUNCT
ecj-12310	81	22	mannitol	mannitol	NOUN
ecj-12310	81	23	crosses	crosse	NOUN
ecj-12310	81	24	the	the	DET
ecj-12310	81	25	vascular	vascular	ADJ
ecj-12310	81	26	wall	wall	NOUN
ecj-12310	81	27	more	more	ADV
ecj-12310	81	28	readily	readily	ADV
ecj-12310	81	29	.	.	PUNCT
ecj-12310	82	1	mannitol	mannitol	NOUN
ecj-12310	82	2	can	can	AUX
ecj-12310	82	3	penetrate	penetrate	VERB
ecj-12310	82	4	the	the	DET
ecj-12310	82	5	blood	blood	NOUN
ecj-12310	82	6	-	-	PUNCT
ecj-12310	82	7	brain	brain	NOUN
ecj-12310	82	8	barrier	barrier	NOUN
ecj-12310	82	9	when	when	SCONJ
ecj-12310	82	10	taken	take	VERB
ecj-12310	82	11	fequently	fequently	NOUN
ecj-12310	82	12	,	,	PUNCT
ecj-12310	82	13	which	which	PRON
ecj-12310	82	14	can	can	AUX
ecj-12310	82	15	exacerbate	exacerbate	VERB
ecj-12310	82	16	cerebral	cerebral	ADJ
ecj-12310	82	17	edema	edema	NOUN
ecj-12310	82	18	because	because	SCONJ
ecj-12310	82	19	the	the	DET
ecj-12310	82	20	mannitol	mannitol	NOUN
ecj-12310	82	21	draws	draw	VERB
ecj-12310	82	22	water	water	NOUN
ecj-12310	82	23	into	into	ADP
ecj-12310	82	24	the	the	DET
ecj-12310	82	25	brain	brain	NOUN
ecj-12310	82	26	rather	rather	ADV
ecj-12310	82	27	than	than	ADP
ecj-12310	82	28	out	out	ADP
ecj-12310	82	29	of	of	ADP
ecj-12310	82	30	it	it	PRON
ecj-12310	82	31	.	.	PUNCT
ecj-12310	83	1	mannitol	mannitol	NOUN
ecj-12310	83	2	treatment	treatment	NOUN
ecj-12310	83	3	may	may	AUX
ecj-12310	83	4	cause	cause	VERB
ecj-12310	83	5	patients	patient	NOUN
ecj-12310	83	6	’	'	PUNCT
ecj-12310	83	7	cerebral	cerebral	ADJ
ecj-12310	83	8	edema	edema	NOUN
ecj-12310	83	9	to	to	PART
ecj-12310	83	10	deteriorate	deteriorate	VERB
ecj-12310	83	11	,	,	PUNCT
ecj-12310	83	12	particularly	particularly	ADV
ecj-12310	83	13	in	in	ADP
ecj-12310	83	14	children	child	NOUN
ecj-12310	83	15	with	with	ADP
ecj-12310	83	16	cerebral	cerebral	ADJ
ecj-12310	83	17	hyperemia.38	hyperemia.38	NOUN
ecj-12310	83	18	hypertonic	hypertonic	ADJ
ecj-12310	83	19	saline	saline	NOUN
ecj-12310	83	20	solution	solution	NOUN
ecj-12310	83	21	(	(	PUNCT
ecj-12310	83	22	hss	hss	NOUN
ecj-12310	83	23	)	)	PUNCT
ecj-12310	83	24	restores	restore	VERB
ecj-12310	83	25	intracranial	intracranial	ADJ
ecj-12310	83	26	compliance	compliance	NOUN
ecj-12310	83	27	,	,	PUNCT
ecj-12310	83	28	extracts	extract	NOUN
ecj-12310	83	29	fluid	fluid	NOUN
ecj-12310	83	30	from	from	ADP
ecj-12310	83	31	the	the	DET
ecj-12310	83	32	interstitial	interstitial	ADJ
ecj-12310	83	33	space	space	NOUN
ecj-12310	83	34	,	,	PUNCT
ecj-12310	83	35	and	and	CCONJ
ecj-12310	83	36	lowers	lower	VERB
ecj-12310	83	37	intracranial	intracranial	ADJ
ecj-12310	83	38	pressure	pressure	NOUN
ecj-12310	83	39	,	,	PUNCT
ecj-12310	83	40	mostly	mostly	ADV
ecj-12310	83	41	by	by	ADP
ecj-12310	83	42	preventing	prevent	VERB
ecj-12310	83	43	the	the	DET
ecj-12310	83	44	buildup	buildup	NOUN
ecj-12310	83	45	of	of	ADP
ecj-12310	83	46	extracellular	extracellular	ADJ
ecj-12310	83	47	osmolytes	osmolyte	NOUN
ecj-12310	83	48	in	in	ADP
ecj-12310	83	49	the	the	DET
ecj-12310	83	50	brain	brain	NOUN
ecj-12310	83	51	that	that	PRON
ecj-12310	83	52	is	be	AUX
ecj-12310	83	53	associated	associate	VERB
ecj-12310	83	54	with	with	ADP
ecj-12310	83	55	blood	blood	NOUN
ecj-12310	83	56	-	-	PUNCT
ecj-12310	83	57	brain	brain	NOUN
ecj-12310	83	58	barrier	barrier	NOUN
ecj-12310	83	59	malfunction.39	malfunction.39	NOUN
ecj-12310	83	60	for	for	ADP
ecj-12310	83	61	the	the	DET
ecj-12310	83	62	treatment	treatment	NOUN
ecj-12310	83	63	of	of	ADP
ecj-12310	83	64	increased	increase	VERB
ecj-12310	83	65	icp	icp	PROPN
ecj-12310	83	66	,	,	PUNCT
ecj-12310	83	67	mannitol	mannitol	NOUN
ecj-12310	83	68	remains	remain	VERB
ecj-12310	83	69	the	the	DET
ecj-12310	83	70	cornerstone	cornerstone	NOUN
ecj-12310	83	71	of	of	ADP
ecj-12310	83	72	hyperosmolar	hyperosmolar	ADJ
ecj-12310	83	73	therapy	therapy	NOUN
ecj-12310	83	74	,	,	PUNCT
ecj-12310	83	75	however	however	ADV
ecj-12310	83	76	,	,	PUNCT
ecj-12310	83	77	a	a	DET
ecj-12310	83	78	bolus	bolus	ADJ
ecj-12310	83	79	infusion	infusion	NOUN
ecj-12310	83	80	of	of	ADP
ecj-12310	83	81	hss	hss	NOUN
ecj-12310	83	82	is	be	AUX
ecj-12310	83	83	more	more	ADJ
ecj-12310	83	84	effective.40	effective.40	NOUN
ecj-12310	83	85	thus	thus	ADV
ecj-12310	83	86	in	in	ADP
ecj-12310	83	87	tbi	tbi	NOUN
ecj-12310	83	88	patients	patient	NOUN
ecj-12310	83	89	without	without	ADP
ecj-12310	83	90	ich	ich	NOUN
ecj-12310	83	91	,	,	PUNCT
ecj-12310	83	92	continuous	continuous	ADJ
ecj-12310	83	93	hss	hss	NOUN
ecj-12310	83	94	infusion	infusion	NOUN
ecj-12310	83	95	enhanced	enhance	VERB
ecj-12310	83	96	cerebral	cerebral	ADJ
ecj-12310	83	97	perfusion	perfusion	NOUN
ecj-12310	83	98	pressure	pressure	NOUN
ecj-12310	83	99	(	(	PUNCT
ecj-12310	83	100	cpp	cpp	NOUN
ecj-12310	83	101	)	)	PUNCT
ecj-12310	83	102	,	,	PUNCT
ecj-12310	83	103	raised	raise	VERB
ecj-12310	83	104	natremia	natremia	NOUN
ecj-12310	83	105	and	and	CCONJ
ecj-12310	83	106	osmolarity	osmolarity	NOUN
ecj-12310	83	107	,	,	PUNCT
ecj-12310	83	108	and	and	CCONJ
ecj-12310	83	109	reduced	reduce	VERB
ecj-12310	83	110	the	the	DET
ecj-12310	83	111	likelihood	likelihood	NOUN
ecj-12310	83	112	of	of	ADP
ecj-12310	83	113	ich.41	ich.41	PRON
ecj-12310	83	114	comparison	comparison	NOUN
ecj-12310	83	115	of	of	ADP
ecj-12310	83	116	hypertonic	hypertonic	ADJ
ecj-12310	83	117	saline	saline	NOUN
ecj-12310	83	118	and	and	CCONJ
ecj-12310	83	119	mannitol	mannitol	NOUN
ecj-12310	83	120	intracranial	intracranial	ADJ
ecj-12310	83	121	pressure	pressure	NOUN
ecj-12310	83	122	is	be	AUX
ecj-12310	83	123	a	a	DET
ecj-12310	83	124	key	key	ADJ
ecj-12310	83	125	indicator	indicator	NOUN
ecj-12310	83	126	of	of	ADP
ecj-12310	83	127	decline	decline	NOUN
ecj-12310	83	128	in	in	ADP
ecj-12310	83	129	neurological	neurological	ADJ
ecj-12310	83	130	function	function	NOUN
ecj-12310	83	131	in	in	ADP
ecj-12310	83	132	patients	patient	NOUN
ecj-12310	83	133	with	with	ADP
ecj-12310	83	134	traumatic	traumatic	ADJ
ecj-12310	83	135	brain	brain	NOUN
ecj-12310	83	136	injury.42	injury.42	NOUN
ecj-12310	83	137	it	it	PRON
ecj-12310	83	138	has	have	AUX
ecj-12310	83	139	also	also	ADV
ecj-12310	83	140	been	be	AUX
ecj-12310	83	141	demonstrated	demonstrate	VERB
ecj-12310	83	142	that	that	SCONJ
ecj-12310	83	143	when	when	SCONJ
ecj-12310	83	144	cerebral	cerebral	ADJ
ecj-12310	83	145	perfusion	perfusion	NOUN
ecj-12310	83	146	pressure	pressure	NOUN
ecj-12310	83	147	is	be	AUX
ecj-12310	83	148	severely	severely	ADV
ecj-12310	83	149	low	low	ADJ
ecj-12310	83	150	(	(	PUNCT
ecj-12310	83	151	50	50	NUM
ecj-12310	83	152	mm	mm	NUM
ecj-12310	83	153	hg	hg	NOUN
ecj-12310	83	154	)	)	PUNCT
ecj-12310	83	155	,	,	PUNCT
ecj-12310	83	156	intracranial	intracranial	ADJ
ecj-12310	83	157	pressure	pressure	NOUN
ecj-12310	83	158	becomes	become	VERB
ecj-12310	83	159	an	an	DET
ecj-12310	83	160	indicator	indicator	NOUN
ecj-12310	83	161	of	of	ADP
ecj-12310	83	162	undesirable	undesirable	ADJ
ecj-12310	83	163	outcome	outcome	NOUN
ecj-12310	83	164	,	,	PUNCT
ecj-12310	83	165	and	and	CCONJ
ecj-12310	83	166	maintaining	maintain	VERB
ecj-12310	83	167	intracranial	intracranial	ADJ
ecj-12310	83	168	pressure	pressure	NOUN
ecj-12310	83	169	in	in	ADP
ecj-12310	83	170	the	the	DET
ecj-12310	83	171	range	range	NOUN
ecj-12310	83	172	of	of	ADP
ecj-12310	83	173	18	18	NUM
ecj-12310	83	174	to	to	PART
ecj-12310	83	175	23	23	NUM
ecj-12310	83	176	mmhg	mmhg	NOUN
ecj-12310	83	177	verifies	verifie	NOUN
ecj-12310	83	178	that	that	SCONJ
ecj-12310	83	179	cerebral	cerebral	ADJ
ecj-12310	83	180	perfusion	perfusion	NOUN
ecj-12310	83	181	pressure	pressure	NOUN
ecj-12310	83	182	remains	remain	VERB
ecj-12310	83	183	constant	constant	ADJ
ecj-12310	83	184	for	for	ADP
ecj-12310	83	185	a	a	DET
ecj-12310	83	186	longer	long	ADJ
ecj-12310	83	187	period.43	period.43	ADJ
ecj-12310	83	188	mannitol	mannitol	NOUN
ecj-12310	83	189	has	have	AUX
ecj-12310	83	190	been	be	AUX
ecj-12310	83	191	utilized	utilize	VERB
ecj-12310	83	192	for	for	ADP
ecj-12310	83	193	years	year	NOUN
ecj-12310	83	194	to	to	PART
ecj-12310	83	195	treat	treat	VERB
ecj-12310	83	196	elevated	elevate	VERB
ecj-12310	83	197	intracranial	intracranial	ADJ
ecj-12310	83	198	pressure	pressure	NOUN
ecj-12310	83	199	.	.	PUNCT
ecj-12310	84	1	recommendations	recommendation	NOUN
ecj-12310	84	2	recently	recently	ADV
ecj-12310	84	3	suggested	suggest	VERB
ecj-12310	84	4	that	that	SCONJ
ecj-12310	84	5	mannitol	mannitol	NOUN
ecj-12310	84	6	is	be	AUX
ecj-12310	84	7	more	more	ADV
ecj-12310	84	8	efficient	efficient	ADJ
ecj-12310	84	9	than	than	ADP
ecj-12310	84	10	barbiturates	barbiturate	NOUN
ecj-12310	84	11	in	in	ADP
ecj-12310	84	12	lowering	lower	VERB
ecj-12310	84	13	intracranial	intracranial	ADJ
ecj-12310	84	14	pressure	pressure	NOUN
ecj-12310	84	15	in	in	ADP
ecj-12310	84	16	people	people	NOUN
ecj-12310	84	17	with	with	ADP
ecj-12310	84	18	traumatic	traumatic	ADJ
ecj-12310	84	19	brain	brain	NOUN
ecj-12310	84	20	injury.44	injury.44	PROPN
ecj-12310	84	21	mannitol	mannitol	NOUN
ecj-12310	84	22	,	,	PUNCT
ecj-12310	84	23	causes	cause	VERB
ecj-12310	84	24	a	a	DET
ecj-12310	84	25	decrease	decrease	NOUN
ecj-12310	84	26	in	in	ADP
ecj-12310	84	27	cerebral	cerebral	ADJ
ecj-12310	84	28	perfusion	perfusion	NOUN
ecj-12310	84	29	pressure	pressure	NOUN
ecj-12310	84	30	due	due	ADP
ecj-12310	84	31	to	to	ADP
ecj-12310	84	32	its	its	PRON
ecj-12310	84	33	diuretic	diuretic	ADJ
ecj-12310	84	34	mechanism	mechanism	NOUN
ecj-12310	84	35	of	of	ADP
ecj-12310	84	36	action	action	NOUN
ecj-12310	84	37	,	,	PUNCT
ecj-12310	84	38	which	which	PRON
ecj-12310	84	39	can	can	AUX
ecj-12310	84	40	cause	cause	VERB
ecj-12310	84	41	the	the	DET
ecj-12310	84	42	development	development	NOUN
ecj-12310	84	43	of	of	ADP
ecj-12310	84	44	several	several	ADJ
ecj-12310	84	45	adverse	adverse	ADJ
ecj-12310	84	46	effects	effect	NOUN
ecj-12310	84	47	,	,	PUNCT
ecj-12310	84	48	including	include	VERB
ecj-12310	84	49	edema	edema	NOUN
ecj-12310	84	50	in	in	ADP
ecj-12310	84	51	the	the	DET
ecj-12310	84	52	lungs	lung	NOUN
ecj-12310	84	53	,	,	PUNCT
ecj-12310	84	54	acute	acute	ADJ
ecj-12310	84	55	kidney	kidney	NOUN
ecj-12310	84	56	dysfunction	dysfunction	NOUN
ecj-12310	84	57	,	,	PUNCT
ecj-12310	84	58	and	and	CCONJ
ecj-12310	84	59	arterial	arterial	ADJ
ecj-12310	84	60	hypotension	hypotension	NOUN
ecj-12310	84	61	,	,	PUNCT
ecj-12310	84	62	which	which	PRON
ecj-12310	84	63	causes	cause	VERB
ecj-12310	84	64	a	a	DET
ecj-12310	84	65	decrease	decrease	NOUN
ecj-12310	84	66	in	in	ADP
ecj-12310	84	67	cerebral	cerebral	ADJ
ecj-12310	84	68	perfusion	perfusion	NOUN
ecj-12310	84	69	pressure	pressure	NOUN
ecj-12310	84	70	due	due	ADP
ecj-12310	84	71	to	to	ADP
ecj-12310	84	72	its	its	PRON
ecj-12310	84	73	diuretic	diuretic	NOUN
ecj-12310	84	74	impact.45	impact.45	NOUN
ecj-12310	84	75	in	in	ADP
ecj-12310	84	76	a	a	DET
ecj-12310	84	77	randomised	randomised	ADJ
ecj-12310	84	78	prospective	prospective	ADJ
ecj-12310	84	79	trial	trial	NOUN
ecj-12310	84	80	conducted	conduct	VERB
ecj-12310	84	81	by	by	ADP
ecj-12310	84	82	vialet	vialet	NOUN
ecj-12310	84	83	et	et	PROPN
ecj-12310	84	84	al	al	PROPN
ecj-12310	84	85	.	.	PROPN
ecj-12310	84	86	,	,	PUNCT
ecj-12310	84	87	the	the	DET
ecj-12310	84	88	patients	patient	NOUN
ecj-12310	84	89	were	be	AUX
ecj-12310	84	90	randomly	randomly	ADV
ecj-12310	84	91	assigned	assign	VERB
ecj-12310	84	92	to	to	ADP
ecj-12310	84	93	one	one	NUM
ecj-12310	84	94	of	of	ADP
ecj-12310	84	95	the	the	DET
ecj-12310	84	96	two	two	NUM
ecj-12310	84	97	groups	group	NOUN
ecj-12310	84	98	:	:	PUNCT
ecj-12310	84	99	one	one	NUM
ecj-12310	84	100	that	that	PRON
ecj-12310	84	101	received	receive	VERB
ecj-12310	84	102	7.5	7.5	NUM
ecj-12310	84	103	%	%	NOUN
ecj-12310	84	104	hypertonic	hypertonic	ADJ
ecj-12310	84	105	saline	saline	NOUN
ecj-12310	84	106	(	(	PUNCT
ecj-12310	84	107	361	361	NUM
ecj-12310	84	108	mosm	mosm	NOUN
ecj-12310	84	109	)	)	PUNCT
ecj-12310	84	110	and	and	CCONJ
ecj-12310	84	111	one	one	NUM
ecj-12310	84	112	that	that	PRON
ecj-12310	84	113	received	receive	VERB
ecj-12310	84	114	20	20	NUM
ecj-12310	84	115	%	%	NOUN
ecj-12310	84	116	mannitol	mannitol	NOUN
ecj-12310	84	117	(	(	PUNCT
ecj-12310	84	118	175	175	NUM
ecj-12310	84	119	mosm	mosm	NOUN
ecj-12310	84	120	)	)	PUNCT
ecj-12310	84	121	in	in	ADP
ecj-12310	84	122	the	the	DET
ecj-12310	84	123	same	same	ADJ
ecj-12310	84	124	amount	amount	NOUN
ecj-12310	84	125	(	(	PUNCT
ecj-12310	84	126	2	2	NUM
ecj-12310	84	127	ml	ml	NOUN
ecj-12310	84	128	/	/	SYM
ecj-12310	84	129	kg	kg	NOUN
ecj-12310	84	130	)	)	PUNCT
ecj-12310	84	131	.	.	PUNCT
ecj-12310	85	1	in	in	ADP
ecj-12310	85	2	comparison	comparison	NOUN
ecj-12310	85	3	to	to	ADP
ecj-12310	85	4	hypertonic	hypertonic	ADJ
ecj-12310	85	5	saline	saline	NOUN
ecj-12310	85	6	,	,	PUNCT
ecj-12310	85	7	the	the	DET
ecj-12310	85	8	mannitol	mannitol	NOUN
ecj-12310	85	9	group	group	NOUN
ecj-12310	85	10	had	have	VERB
ecj-12310	85	11	greater	great	ADJ
ecj-12310	85	12	total	total	NOUN
ecj-12310	85	13	and	and	CCONJ
ecj-12310	85	14	duration	duration	NOUN
ecj-12310	85	15	of	of	ADP
ecj-12310	85	16	daily	daily	ADJ
ecj-12310	85	17	periods	period	NOUN
ecj-12310	85	18	of	of	ADP
ecj-12310	85	19	icp	icp	PROPN
ecj-12310	85	20	>	>	X
ecj-12310	85	21	25	25	NUM
ecj-12310	85	22	mmhg	mmhg	NOUN
ecj-12310	85	23	and	and	CCONJ
ecj-12310	85	24	needed	need	VERB
ecj-12310	85	25	more	more	ADJ
ecj-12310	85	26	csf	csf	ADJ
ecj-12310	85	27	fluid	fluid	ADJ
ecj-12310	85	28	drainage	drainage	NOUN
ecj-12310	85	29	.	.	PUNCT
ecj-12310	86	1	this	this	DET
ecj-12310	86	2	study	study	NOUN
ecj-12310	86	3	also	also	ADV
ecj-12310	86	4	found	find	VERB
ecj-12310	86	5	that	that	SCONJ
ecj-12310	86	6	treatment	treatment	NOUN
ecj-12310	86	7	failure	failure	NOUN
ecj-12310	86	8	was	be	AUX
ecj-12310	86	9	70	70	NUM
ecj-12310	86	10	%	%	NOUN
ecj-12310	86	11	higher	high	ADJ
ecj-12310	86	12	in	in	ADP
ecj-12310	86	13	the	the	DET
ecj-12310	86	14	mannitol	mannitol	NOUN
ecj-12310	86	15	group	group	NOUN
ecj-12310	86	16	compared	compare	VERB
ecj-12310	86	17	to	to	ADP
ecj-12310	86	18	10	10	NUM
ecj-12310	86	19	%	%	NOUN
ecj-12310	86	20	in	in	ADP
ecj-12310	86	21	the	the	DET
ecj-12310	86	22	hypertonic	hypertonic	ADJ
ecj-12310	86	23	saline	saline	NOUN
ecj-12310	86	24	group	group	NOUN
ecj-12310	86	25	.	.	PUNCT
ecj-12310	87	1	there	there	PRON
ecj-12310	87	2	was	be	VERB
ecj-12310	87	3	no	no	DET
ecj-12310	87	4	significant	significant	ADJ
ecj-12310	87	5	difference	difference	NOUN
ecj-12310	87	6	in	in	ADP
ecj-12310	87	7	mortality	mortality	NOUN
ecj-12310	87	8	or	or	CCONJ
ecj-12310	87	9	neurological	neurological	ADJ
ecj-12310	87	10	improvement	improvement	NOUN
ecj-12310	87	11	after	after	ADP
ecj-12310	87	12	90	90	NUM
ecj-12310	87	13	days	day	NOUN
ecj-12310	87	14	.	.	PUNCT
ecj-12310	88	1	it	it	PRON
ecj-12310	88	2	was	be	AUX
ecj-12310	88	3	noted	note	VERB
ecj-12310	88	4	that	that	SCONJ
ecj-12310	88	5	the	the	DET
ecj-12310	88	6	study	study	NOUN
ecj-12310	88	7	used	use	VERB
ecj-12310	88	8	both	both	DET
ecj-12310	88	9	fluids	fluid	NOUN
ecj-12310	88	10	with	with	ADP
ecj-12310	88	11	different	different	ADJ
ecj-12310	88	12	osmolarities.46	osmolarities.46	NOUN
ecj-12310	88	13	the	the	DET
ecj-12310	88	14	optimum	optimum	ADJ
ecj-12310	88	15	therapeutic	therapeutic	ADJ
ecj-12310	88	16	agent	agent	NOUN
ecj-12310	88	17	for	for	ADP
ecj-12310	88	18	controlling	control	VERB
ecj-12310	88	19	intracranial	intracranial	ADJ
ecj-12310	88	20	pressure	pressure	NOUN
ecj-12310	88	21	should	should	AUX
ecj-12310	88	22	reduce	reduce	VERB
ecj-12310	88	23	intracranial	intracranial	ADJ
ecj-12310	88	24	pressure	pressure	NOUN
ecj-12310	88	25	while	while	SCONJ
ecj-12310	88	26	maintaining	maintain	VERB
ecj-12310	88	27	cerebral	cerebral	ADJ
ecj-12310	88	28	perfusion	perfusion	NOUN
ecj-12310	88	29	.	.	PUNCT
ecj-12310	89	1	hypertonic	hypertonic	ADJ
ecj-12310	89	2	saline	saline	NOUN
ecj-12310	89	3	boosts	boost	VERB
ecj-12310	89	4	serum	serum	NOUN
ecj-12310	89	5	sodium	sodium	NOUN
ecj-12310	89	6	and	and	CCONJ
ecj-12310	89	7	osmolality	osmolality	NOUN
ecj-12310	89	8	considerably	considerably	ADV
ecj-12310	89	9	.	.	PUNCT
ecj-12310	90	1	excessive	excessive	ADJ
ecj-12310	90	2	salt	salt	NOUN
ecj-12310	90	3	levels	level	NOUN
ecj-12310	90	4	and	and	CCONJ
ecj-12310	90	5	osmolarity	osmolarity	NOUN
ecj-12310	90	6	produce	produce	VERB
ecj-12310	90	7	an	an	DET
ecj-12310	90	8	overload	overload	NOUN
ecj-12310	90	9	of	of	ADP
ecj-12310	90	10	volume	volume	NOUN
ecj-12310	90	11	,	,	PUNCT
ecj-12310	90	12	edema	edema	NOUN
ecj-12310	90	13	of	of	ADP
ecj-12310	90	14	the	the	DET
ecj-12310	90	15	lungs	lung	NOUN
ecj-12310	90	16	,	,	PUNCT
ecj-12310	90	17	and	and	CCONJ
ecj-12310	90	18	heart	heart	NOUN
ecj-12310	90	19	failure	failure	NOUN
ecj-12310	90	20	,	,	PUNCT
ecj-12310	90	21	or	or	CCONJ
ecj-12310	90	22	they	they	PRON
ecj-12310	90	23	might	might	AUX
ecj-12310	90	24	begin	begin	VERB
ecj-12310	90	25	coagulopathy	coagulopathy	ADJ
ecj-12310	90	26	and	and	CCONJ
ecj-12310	90	27	hyperchloremic	hyperchloremic	ADJ
ecj-12310	90	28	metabolic	metabolic	NOUN
ecj-12310	90	29	acidosis	acidosis	NOUN
ecj-12310	90	30	.	.	PUNCT
ecj-12310	91	1	thus	thus	ADV
ecj-12310	91	2	,	,	PUNCT
ecj-12310	91	3	hypertonic	hypertonic	ADJ
ecj-12310	91	4	solutions	solution	NOUN
ecj-12310	91	5	should	should	AUX
ecj-12310	91	6	be	be	AUX
ecj-12310	91	7	administered	administer	VERB
ecj-12310	91	8	with	with	ADP
ecj-12310	91	9	caution	caution	NOUN
ecj-12310	91	10	and	and	CCONJ
ecj-12310	91	11	under	under	ADP
ecj-12310	91	12	constant	constant	ADJ
ecj-12310	91	13	cardiac	cardiac	ADJ
ecj-12310	91	14	surveillance	surveillance	NOUN
ecj-12310	91	15	in	in	ADP
ecj-12310	91	16	individuals	individual	NOUN
ecj-12310	91	17	with	with	ADP
ecj-12310	91	18	impaired	impaired	ADJ
ecj-12310	91	19	cardiac	cardiac	ADJ
ecj-12310	91	20	function.47	function.47	NOUN
ecj-12310	91	21	-	-	PUNCT
ecj-12310	91	22	48	48	NUM
ecj-12310	91	23	in	in	ADP
ecj-12310	91	24	patients	patient	NOUN
ecj-12310	91	25	with	with	ADP
ecj-12310	91	26	head	head	NOUN
ecj-12310	91	27	trauma	trauma	NOUN
ecj-12310	91	28	(	(	PUNCT
ecj-12310	91	29	whether	whether	SCONJ
ecj-12310	91	30	single	single	ADJ
ecj-12310	91	31	or	or	CCONJ
ecj-12310	91	32	numerous	numerous	ADJ
ecj-12310	91	33	injuries	injury	NOUN
ecj-12310	91	34	)	)	PUNCT
ecj-12310	91	35	,	,	PUNCT
ecj-12310	91	36	it	it	PRON
ecj-12310	91	37	is	be	AUX
ecj-12310	91	38	important	important	ADJ
ecj-12310	91	39	to	to	PART
ecj-12310	91	40	avoid	avoid	VERB
ecj-12310	91	41	hypotension	hypotension	NOUN
ecj-12310	91	42	,	,	PUNCT
ecj-12310	91	43	since	since	SCONJ
ecj-12310	91	44	it	it	PRON
ecj-12310	91	45	boosts	boost	VERB
ecj-12310	91	46	the	the	DET
ecj-12310	91	47	incidence	incidence	NOUN
ecj-12310	91	48	of	of	ADP
ecj-12310	91	49	mortality	mortality	NOUN
ecj-12310	91	50	in	in	ADP
ecj-12310	91	51	this	this	DET
ecj-12310	91	52	context.49	context.49	NOUN
ecj-12310	91	53	in	in	ADP
ecj-12310	91	54	contrast	contrast	NOUN
ecj-12310	91	55	to	to	ADP
ecj-12310	91	56	mannitol	mannitol	NOUN
ecj-12310	91	57	,	,	PUNCT
ecj-12310	91	58	an	an	DET
ecj-12310	91	59	osmotic	osmotic	ADJ
ecj-12310	91	60	diuretic	diuretic	NOUN
ecj-12310	91	61	,	,	PUNCT
ecj-12310	91	62	hts	hts	PROPN
ecj-12310	91	63	preserves	preserve	NOUN
ecj-12310	91	64	and	and	CCONJ
ecj-12310	91	65	even	even	ADV
ecj-12310	91	66	improves	improve	VERB
ecj-12310	91	67	the	the	DET
ecj-12310	91	68	mean	mean	ADJ
ecj-12310	91	69	arterial	arterial	ADJ
ecj-12310	91	70	blood	blood	NOUN
ecj-12310	91	71	pressure	pressure	NOUN
ecj-12310	91	72	in	in	ADP
ecj-12310	91	73	various	various	ADJ
ecj-12310	91	74	review	review	NOUN
ecj-12310	91	75	[	[	X
ecj-12310	91	76	page	page	NOUN
ecj-12310	91	77	33	33	NUM
ecj-12310	91	78	]	]	PUNCT
ecj-12310	92	1	[	[	X
ecj-12310	92	2	emergency	emergency	NOUN
ecj-12310	92	3	care	care	NOUN
ecj-12310	92	4	journal	journal	PROPN
ecj-12310	92	5	2024	2024	NUM
ecj-12310	92	6	;	;	PUNCT
ecj-12310	92	7	20:12310	20:12310	NUM
ecj-12310	92	8	]	]	X
ecj-12310	92	9	non	non	ADJ
ecj-12310	92	10	-co	-co	PROPN
ecj-12310	92	11	mmerc	mmerc	PROPN
ecj-12310	92	12	ial	ial	PROPN
ecj-12310	92	13	us	us	PROPN
ecj-12310	92	14	e	e	NOUN
ecj-12310	92	15	o	o	NOUN
ecj-12310	92	16	nly	nly	ADV
ecj-12310	92	17	kinds	kind	NOUN
ecj-12310	92	18	of	of	ADP
ecj-12310	92	19	shock.50	shock.50	NOUN
ecj-12310	92	20	isotonic	isotonic	ADJ
ecj-12310	92	21	resuscitation	resuscitation	NOUN
ecj-12310	92	22	using	use	VERB
ecj-12310	92	23	fluids	fluid	NOUN
ecj-12310	92	24	in	in	ADP
ecj-12310	92	25	the	the	DET
ecj-12310	92	26	trauma	trauma	NOUN
ecj-12310	92	27	circumstance	circumstance	NOUN
ecj-12310	92	28	,	,	PUNCT
ecj-12310	92	29	necessitates	necessitate	VERB
ecj-12310	92	30	a	a	DET
ecj-12310	92	31	large	large	ADJ
ecj-12310	92	32	amount	amount	NOUN
ecj-12310	92	33	of	of	ADP
ecj-12310	92	34	fluid	fluid	NOUN
ecj-12310	92	35	,	,	PUNCT
ecj-12310	92	36	which	which	PRON
ecj-12310	92	37	can	can	AUX
ecj-12310	92	38	raise	raise	VERB
ecj-12310	92	39	icp	icp	PROPN
ecj-12310	92	40	.	.	PUNCT
ecj-12310	93	1	the	the	DET
ecj-12310	93	2	significant	significant	ADJ
ecj-12310	93	3	benefit	benefit	NOUN
ecj-12310	93	4	of	of	ADP
ecj-12310	93	5	hts	hts	PROPN
ecj-12310	93	6	in	in	ADP
ecj-12310	93	7	this	this	DET
ecj-12310	93	8	context	context	NOUN
ecj-12310	93	9	is	be	AUX
ecj-12310	93	10	that	that	SCONJ
ecj-12310	93	11	blood	blood	NOUN
ecj-12310	93	12	pressure	pressure	NOUN
ecj-12310	93	13	is	be	AUX
ecj-12310	93	14	maintained	maintain	VERB
ecj-12310	93	15	with	with	ADP
ecj-12310	93	16	minimal	minimal	ADJ
ecj-12310	93	17	volume	volume	NOUN
ecj-12310	93	18	resuscitation	resuscitation	NOUN
ecj-12310	93	19	,	,	PUNCT
ecj-12310	93	20	preventing	prevent	VERB
ecj-12310	93	21	possible	possible	ADJ
ecj-12310	93	22	iatrogenic	iatrogenic	ADJ
ecj-12310	93	23	icp	icp	PROPN
ecj-12310	93	24	elevations.51	elevations.51	PROPN
ecj-12310	93	25	intravenous	intravenous	PROPN
ecj-12310	93	26	administration	administration	NOUN
ecj-12310	93	27	of	of	ADP
ecj-12310	93	28	hypertonic	hypertonic	ADJ
ecj-12310	93	29	saline	saline	NOUN
ecj-12310	93	30	increased	increase	VERB
ecj-12310	93	31	cerebral	cerebral	ADJ
ecj-12310	93	32	perfusion	perfusion	NOUN
ecj-12310	93	33	and	and	CCONJ
ecj-12310	93	34	shifted	shift	VERB
ecj-12310	93	35	the	the	DET
ecj-12310	93	36	oxygen	oxygen	NOUN
ecj-12310	93	37	dissociation	dissociation	NOUN
ecj-12310	93	38	curve	curve	NOUN
ecj-12310	93	39	,	,	PUNCT
ecj-12310	93	40	thus	thus	ADV
ecj-12310	93	41	boosting	boost	VERB
ecj-12310	93	42	the	the	DET
ecj-12310	93	43	availability	availability	NOUN
ecj-12310	93	44	of	of	ADP
ecj-12310	93	45	oxygen	oxygen	NOUN
ecj-12310	93	46	and	and	CCONJ
ecj-12310	93	47	brain	brain	NOUN
ecj-12310	93	48	responsiveness	responsiveness	NOUN
ecj-12310	93	49	while	while	SCONJ
ecj-12310	93	50	decreasing	decrease	VERB
ecj-12310	93	51	intracranial	intracranial	ADJ
ecj-12310	93	52	pressure	pressure	NOUN
ecj-12310	93	53	and	and	CCONJ
ecj-12310	93	54	cerebral	cerebral	ADJ
ecj-12310	93	55	edema.52	edema.52	PROPN
ecj-12310	93	56	hts	hts	PROPN
ecj-12310	93	57	may	may	AUX
ecj-12310	93	58	have	have	VERB
ecj-12310	93	59	a	a	DET
ecj-12310	93	60	role	role	NOUN
ecj-12310	93	61	in	in	ADP
ecj-12310	93	62	brain	brain	NOUN
ecj-12310	93	63	cell	cell	NOUN
ecj-12310	93	64	immune	immune	ADJ
ecj-12310	93	65	system	system	NOUN
ecj-12310	93	66	regulation	regulation	NOUN
ecj-12310	93	67	,	,	PUNCT
ecj-12310	93	68	perhaps	perhaps	ADV
ecj-12310	93	69	leading	lead	VERB
ecj-12310	93	70	to	to	ADP
ecj-12310	93	71	beneficial	beneficial	ADJ
ecj-12310	93	72	effects	effect	NOUN
ecj-12310	93	73	on	on	ADP
ecj-12310	93	74	inflammation	inflammation	NOUN
ecj-12310	93	75	and	and	CCONJ
ecj-12310	93	76	a	a	DET
ecj-12310	93	77	better	well	ADJ
ecj-12310	93	78	prognosis	prognosis	NOUN
ecj-12310	93	79	for	for	ADP
ecj-12310	93	80	tbi	tbi	NOUN
ecj-12310	93	81	patients	patient	NOUN
ecj-12310	93	82	.	.	PUNCT
ecj-12310	94	1	the	the	DET
ecj-12310	94	2	inflammatory	inflammatory	ADJ
ecj-12310	94	3	cascade	cascade	NOUN
ecj-12310	94	4	is	be	AUX
ecj-12310	94	5	activated	activate	VERB
ecj-12310	94	6	by	by	ADP
ecj-12310	94	7	severe	severe	ADJ
ecj-12310	94	8	trauma	trauma	NOUN
ecj-12310	94	9	,	,	PUNCT
ecj-12310	94	10	resulting	result	VERB
ecj-12310	94	11	in	in	ADP
ecj-12310	94	12	systemic	systemic	ADJ
ecj-12310	94	13	allergic	allergic	ADJ
ecj-12310	94	14	reaction	reaction	NOUN
ecj-12310	94	15	syndrome	syndrome	NOUN
ecj-12310	94	16	.	.	PUNCT
ecj-12310	95	1	furthermore	furthermore	ADV
ecj-12310	95	2	,	,	PUNCT
ecj-12310	95	3	cerebral	cerebral	ADJ
ecj-12310	95	4	leukocytes	leukocyte	NOUN
ecj-12310	95	5	move	move	VERB
ecj-12310	95	6	to	to	ADP
ecj-12310	95	7	wounded	wound	VERB
ecj-12310	95	8	regions	region	NOUN
ecj-12310	95	9	in	in	ADP
ecj-12310	95	10	response	response	NOUN
ecj-12310	95	11	to	to	ADP
ecj-12310	95	12	tbi	tbi	PROPN
ecj-12310	95	13	,	,	PUNCT
ecj-12310	95	14	resulting	result	VERB
ecj-12310	95	15	in	in	ADP
ecj-12310	95	16	peroxidaseand	peroxidaseand	NOUN
ecj-12310	95	17	protease	protease	NOUN
ecj-12310	95	18	-	-	PUNCT
ecj-12310	95	19	mediated	mediate	VERB
ecj-12310	95	20	cell	cell	NOUN
ecj-12310	95	21	death.53	death.53	NOUN
ecj-12310	95	22	the	the	DET
ecj-12310	95	23	study	study	NOUN
ecj-12310	95	24	conducted	conduct	VERB
ecj-12310	95	25	by	by	ADP
ecj-12310	95	26	battison	battison	PROPN
ecj-12310	95	27	et	et	PROPN
ecj-12310	95	28	al	al	PROPN
ecj-12310	95	29	.	.	PROPN
ecj-12310	96	1	in	in	ADP
ecj-12310	96	2	2005	2005	NUM
ecj-12310	96	3	discovered	discover	VERB
ecj-12310	96	4	that	that	SCONJ
ecj-12310	96	5	both	both	PRON
ecj-12310	96	6	mannitol	mannitol	NOUN
ecj-12310	96	7	and	and	CCONJ
ecj-12310	96	8	hypertonic	hypertonic	ADJ
ecj-12310	96	9	saline	saline	NOUN
ecj-12310	96	10	considerably	considerably	ADV
ecj-12310	96	11	lowered	lower	VERB
ecj-12310	96	12	icp	icp	PROPN
ecj-12310	96	13	,	,	PUNCT
ecj-12310	96	14	however	however	ADV
ecj-12310	96	15	hypertonic	hypertonic	ADJ
ecj-12310	96	16	saline	saline	NOUN
ecj-12310	96	17	dramatically	dramatically	ADV
ecj-12310	96	18	reduced	reduce	VERB
ecj-12310	96	19	icp	icp	PROPN
ecj-12310	96	20	more	more	ADV
ecj-12310	96	21	strongly	strongly	ADV
ecj-12310	96	22	and	and	CCONJ
ecj-12310	96	23	for	for	ADP
ecj-12310	96	24	an	an	DET
ecj-12310	96	25	extended	extended	ADJ
ecj-12310	96	26	period	period	NOUN
ecj-12310	96	27	than	than	ADP
ecj-12310	96	28	mannitol	mannitol	NOUN
ecj-12310	96	29	.	.	PUNCT
ecj-12310	97	1	the	the	DET
ecj-12310	97	2	usage	usage	NOUN
ecj-12310	97	3	of	of	ADP
ecj-12310	97	4	the	the	DET
ecj-12310	97	5	identical	identical	ADJ
ecj-12310	97	6	osmolarity	osmolarity	NOUN
ecj-12310	97	7	between	between	ADP
ecj-12310	97	8	the	the	DET
ecj-12310	97	9	two	two	NUM
ecj-12310	97	10	fluids	fluid	NOUN
ecj-12310	97	11	is	be	AUX
ecj-12310	97	12	the	the	DET
ecj-12310	97	13	study	study	NOUN
ecj-12310	97	14	’s	’s	PART
ecj-12310	97	15	key	key	ADJ
ecj-12310	97	16	strength.54	strength.54	NOUN
ecj-12310	97	17	in	in	ADP
ecj-12310	97	18	the	the	DET
ecj-12310	97	19	final	final	ADJ
ecj-12310	97	20	analysis	analysis	NOUN
ecj-12310	97	21	,	,	PUNCT
ecj-12310	97	22	mannitol	mannitol	NOUN
ecj-12310	97	23	is	be	AUX
ecj-12310	97	24	regarded	regard	VERB
ecj-12310	97	25	as	as	ADP
ecj-12310	97	26	the	the	DET
ecj-12310	97	27	“	"	PUNCT
ecj-12310	97	28	standard	standard	NOUN
ecj-12310	97	29	of	of	ADP
ecj-12310	97	30	care	care	NOUN
ecj-12310	97	31	”	"	PUNCT
ecj-12310	97	32	treatment	treatment	NOUN
ecj-12310	97	33	for	for	ADP
ecj-12310	97	34	tbiinduced	tbiinduced	ADJ
ecj-12310	97	35	intracranial	intracranial	ADJ
ecj-12310	97	36	hypertension	hypertension	NOUN
ecj-12310	97	37	because	because	SCONJ
ecj-12310	97	38	of	of	ADP
ecj-12310	97	39	its	its	PRON
ecj-12310	97	40	historical	historical	ADJ
ecj-12310	97	41	use	use	NOUN
ecj-12310	97	42	rather	rather	ADV
ecj-12310	97	43	than	than	ADP
ecj-12310	97	44	its	its	PRON
ecj-12310	97	45	efficacy	efficacy	NOUN
ecj-12310	97	46	against	against	ADP
ecj-12310	97	47	hts	hts	PROPN
ecj-12310	97	48	.	.	PUNCT
ecj-12310	98	1	hts	hts	PROPN
ecj-12310	98	2	offers	offer	VERB
ecj-12310	98	3	numerous	numerous	ADJ
ecj-12310	98	4	theoretical	theoretical	ADJ
ecj-12310	98	5	benefits	benefit	NOUN
ecj-12310	98	6	over	over	ADP
ecj-12310	98	7	mannitol	mannitol	NOUN
ecj-12310	98	8	in	in	ADP
ecj-12310	98	9	terms	term	NOUN
ecj-12310	98	10	of	of	ADP
ecj-12310	98	11	physiology	physiology	NOUN
ecj-12310	98	12	.	.	PUNCT
ecj-12310	99	1	in	in	ADP
ecj-12310	99	2	clinical	clinical	ADJ
ecj-12310	99	3	terms	term	NOUN
ecj-12310	99	4	,	,	PUNCT
ecj-12310	99	5	hts	hts	PROPN
ecj-12310	99	6	appears	appear	VERB
ecj-12310	99	7	to	to	PART
ecj-12310	99	8	be	be	AUX
ecj-12310	99	9	more	more	ADV
ecj-12310	99	10	effective	effective	ADJ
ecj-12310	99	11	than	than	ADP
ecj-12310	99	12	mannitol	mannitol	NOUN
ecj-12310	99	13	in	in	ADP
ecj-12310	99	14	lowering	lower	VERB
ecj-12310	99	15	icp	icp	PROPN
ecj-12310	99	16	,	,	PUNCT
ecj-12310	99	17	both	both	CCONJ
ecj-12310	99	18	in	in	ADP
ecj-12310	99	19	terms	term	NOUN
ecj-12310	99	20	of	of	ADP
ecj-12310	99	21	degree	degree	NOUN
ecj-12310	99	22	and	and	CCONJ
ecj-12310	99	23	duration	duration	NOUN
ecj-12310	99	24	of	of	ADP
ecj-12310	99	25	decrease	decrease	NOUN
ecj-12310	99	26	.	.	PUNCT
ecj-12310	100	1	ultimately	ultimately	ADV
ecj-12310	100	2	,	,	PUNCT
ecj-12310	100	3	hts	hts	PROPN
ecj-12310	100	4	appears	appear	VERB
ecj-12310	100	5	to	to	PART
ecj-12310	100	6	promote	promote	VERB
ecj-12310	100	7	brain	brain	NOUN
ecj-12310	100	8	tissue	tissue	NOUN
ecj-12310	100	9	oxygenation	oxygenation	NOUN
ecj-12310	100	10	more	more	ADJ
ecj-12310	100	11	than	than	ADP
ecj-12310	100	12	mannitol	mannitol	NOUN
ecj-12310	100	13	.	.	PUNCT
ecj-12310	101	1	all	all	PRON
ecj-12310	101	2	of	of	ADP
ecj-12310	101	3	these	these	DET
ecj-12310	101	4	benefits	benefit	NOUN
ecj-12310	101	5	imply	imply	VERB
ecj-12310	101	6	that	that	SCONJ
ecj-12310	101	7	hts	hts	PROPN
ecj-12310	101	8	should	should	AUX
ecj-12310	101	9	be	be	AUX
ecj-12310	101	10	thoroughly	thoroughly	ADV
ecj-12310	101	11	researched	research	VERB
ecj-12310	101	12	so	so	SCONJ
ecj-12310	101	13	that	that	SCONJ
ecj-12310	101	14	it	it	PRON
ecj-12310	101	15	might	might	AUX
ecj-12310	101	16	potentially	potentially	ADV
ecj-12310	101	17	be	be	AUX
ecj-12310	101	18	utilized	utilize	VERB
ecj-12310	101	19	as	as	ADP
ecj-12310	101	20	an	an	DET
ecj-12310	101	21	alternative	alternative	NOUN
ecj-12310	101	22	to	to	ADP
ecj-12310	101	23	mannitol	mannitol	NOUN
ecj-12310	101	24	as	as	ADP
ecj-12310	101	25	a	a	DET
ecj-12310	101	26	first	first	ADJ
ecj-12310	101	27	-	-	PUNCT
ecj-12310	101	28	line	line	NOUN
ecj-12310	101	29	treatment	treatment	NOUN
ecj-12310	101	30	for	for	ADP
ecj-12310	101	31	the	the	DET
ecj-12310	101	32	management	management	NOUN
ecj-12310	101	33	of	of	ADP
ecj-12310	101	34	elevated	elevate	VERB
ecj-12310	101	35	icp	icp	PROPN
ecj-12310	101	36	in	in	ADP
ecj-12310	101	37	tbi	tbi	NOUN
ecj-12310	101	38	patients	patient	NOUN
ecj-12310	101	39	.	.	PUNCT
ecj-12310	102	1	it	it	PRON
ecj-12310	102	2	is	be	AUX
ecj-12310	102	3	uncertain	uncertain	ADJ
ecj-12310	102	4	if	if	SCONJ
ecj-12310	102	5	a	a	DET
ecj-12310	102	6	bolus	bolus	ADJ
ecj-12310	102	7	dosage	dosage	NOUN
ecj-12310	102	8	or	or	CCONJ
ecj-12310	102	9	an	an	DET
ecj-12310	102	10	infusion	infusion	NOUN
ecj-12310	102	11	is	be	AUX
ecj-12310	102	12	required	require	VERB
ecj-12310	102	13	.	.	PUNCT
ecj-12310	103	1	the	the	DET
ecj-12310	103	2	bolus	bolus	ADJ
ecj-12310	103	3	dosage	dosage	NOUN
ecj-12310	103	4	was	be	AUX
ecj-12310	103	5	administered	administer	VERB
ecj-12310	103	6	at	at	ADP
ecj-12310	103	7	various	various	ADJ
ecj-12310	103	8	proportions	proportion	NOUN
ecj-12310	103	9	with	with	ADP
ecj-12310	103	10	no	no	DET
ecj-12310	103	11	indication	indication	NOUN
ecj-12310	103	12	of	of	ADP
ecj-12310	103	13	superiority	superiority	NOUN
ecj-12310	103	14	of	of	ADP
ecj-12310	103	15	any	any	DET
ecj-12310	103	16	concentration	concentration	NOUN
ecj-12310	103	17	in	in	ADP
ecj-12310	103	18	particular	particular	ADJ
ecj-12310	103	19	,	,	PUNCT
ecj-12310	103	20	although	although	SCONJ
ecj-12310	103	21	total	total	ADJ
ecj-12310	103	22	osmolar	osmolar	ADJ
ecj-12310	103	23	load	load	NOUN
ecj-12310	103	24	must	must	AUX
ecj-12310	103	25	be	be	AUX
ecj-12310	103	26	considered	consider	VERB
ecj-12310	103	27	.	.	PUNCT
ecj-12310	104	1	infusions	infusion	NOUN
ecj-12310	104	2	with	with	ADP
ecj-12310	104	3	3	3	NUM
ecj-12310	104	4	%	%	NOUN
ecj-12310	104	5	hts	ht	NOUN
ecj-12310	104	6	at	at	ADP
ecj-12310	104	7	a	a	DET
ecj-12310	104	8	rate	rate	NOUN
ecj-12310	104	9	of	of	ADP
ecj-12310	104	10	0.1	0.1	NUM
ecj-12310	104	11	-	-	PUNCT
ecj-12310	104	12	2ml	2ml	NOUN
ecj-12310	104	13	/	/	SYM
ecj-12310	104	14	kg	kg	NOUN
ecj-12310	104	15	/	/	SYM
ecj-12310	104	16	h	h	NOUN
ecj-12310	104	17	have	have	AUX
ecj-12310	104	18	been	be	AUX
ecj-12310	104	19	proven	prove	VERB
ecj-12310	104	20	to	to	PART
ecj-12310	104	21	be	be	AUX
ecj-12310	104	22	successful	successful	ADJ
ecj-12310	104	23	,	,	PUNCT
ecj-12310	104	24	with	with	ADP
ecj-12310	104	25	step	step	NOUN
ecj-12310	104	26	-	-	PUNCT
ecj-12310	104	27	wise	wise	ADJ
ecj-12310	104	28	titration	titration	NOUN
ecj-12310	104	29	of	of	ADP
ecj-12310	104	30	the	the	DET
ecj-12310	104	31	dosage	dosage	NOUN
ecj-12310	104	32	to	to	ADP
ecj-12310	104	33	a	a	DET
ecj-12310	104	34	goal	goal	NOUN
ecj-12310	104	35	of	of	ADP
ecj-12310	104	36	145	145	NUM
ecj-12310	104	37	-	-	SYM
ecj-12310	104	38	155meq	155meq	NUM
ecj-12310	104	39	/	/	SYM
ecj-12310	104	40	l	l	NOUN
ecj-12310	104	41	na+	na+	NOUN
ecj-12310	104	42	(	(	PUNCT
ecj-12310	104	43	maximum	maximum	ADJ
ecj-12310	104	44	160meq	160meq	NUM
ecj-12310	104	45	/	/	SYM
ecj-12310	104	46	l	l	NOUN
ecj-12310	104	47	)	)	PUNCT
ecj-12310	104	48	and	and	CCONJ
ecj-12310	104	49	an	an	DET
ecj-12310	104	50	osmolality	osmolality	NOUN
ecj-12310	104	51	of	of	ADP
ecj-12310	104	52	320	320	NUM
ecj-12310	104	53	-	-	PUNCT
ecj-12310	104	54	330mosm	330mosm	NUM
ecj-12310	104	55	/	/	SYM
ecj-12310	104	56	l	l	NOUN
ecj-12310	104	57	(	(	PUNCT
ecj-12310	104	58	maximum	maximum	ADJ
ecj-12310	104	59	360meq	360meq	NUM
ecj-12310	104	60	/	/	SYM
ecj-12310	104	61	l	l	NOUN
ecj-12310	104	62	)	)	PUNCT
ecj-12310	104	63	.	.	PUNCT
ecj-12310	105	1	according	accord	VERB
ecj-12310	105	2	to	to	ADP
ecj-12310	105	3	the	the	DET
ecj-12310	105	4	literature	literature	NOUN
ecj-12310	105	5	,	,	PUNCT
ecj-12310	105	6	hts	hts	PROPN
ecj-12310	105	7	infusion	infusion	NOUN
ecj-12310	105	8	decreases	decrease	VERB
ecj-12310	105	9	icp	icp	PROPN
ecj-12310	105	10	over	over	ADP
ecj-12310	105	11	72	72	NUM
ecj-12310	105	12	hours	hour	NOUN
ecj-12310	105	13	,	,	PUNCT
ecj-12310	105	14	however	however	ADV
ecj-12310	105	15	,	,	PUNCT
ecj-12310	105	16	this	this	DET
ecj-12310	105	17	effect	effect	NOUN
ecj-12310	105	18	can	can	AUX
ecj-12310	105	19	not	not	PART
ecj-12310	105	20	be	be	AUX
ecj-12310	105	21	sustained	sustain	VERB
ecj-12310	105	22	with	with	ADP
ecj-12310	105	23	continued	continue	VERB
ecj-12310	105	24	treatment	treatment	NOUN
ecj-12310	105	25	.	.	PUNCT
ecj-12310	106	1	the	the	DET
ecj-12310	106	2	bolus	bolus	ADJ
ecj-12310	106	3	dosage	dosage	NOUN
ecj-12310	106	4	can	can	AUX
ecj-12310	106	5	be	be	AUX
ecj-12310	106	6	administered	administer	VERB
ecj-12310	106	7	alone	alone	ADJ
ecj-12310	106	8	or	or	CCONJ
ecj-12310	106	9	in	in	ADP
ecj-12310	106	10	conjunction	conjunction	NOUN
ecj-12310	106	11	with	with	ADP
ecj-12310	106	12	continuous	continuous	ADJ
ecj-12310	106	13	infusion	infusion	NOUN
ecj-12310	106	14	treatment	treatment	NOUN
ecj-12310	106	15	.	.	PUNCT
ecj-12310	107	1	it	it	PRON
ecj-12310	107	2	is	be	AUX
ecj-12310	107	3	also	also	ADV
ecj-12310	107	4	used	use	VERB
ecj-12310	107	5	to	to	PART
ecj-12310	107	6	reduce	reduce	VERB
ecj-12310	107	7	icp	icp	PROPN
ecj-12310	107	8	in	in	ADP
ecj-12310	107	9	people	people	NOUN
ecj-12310	107	10	who	who	PRON
ecj-12310	107	11	have	have	AUX
ecj-12310	107	12	not	not	PART
ecj-12310	107	13	had	have	VERB
ecj-12310	107	14	surgery.55	surgery.55	NOUN
ecj-12310	107	15	in	in	ADP
ecj-12310	107	16	the	the	DET
ecj-12310	107	17	study	study	NOUN
ecj-12310	107	18	conducted	conduct	VERB
ecj-12310	107	19	by	by	ADP
ecj-12310	107	20	de	de	X
ecj-12310	107	21	vivo	vivo	NOUN
ecj-12310	107	22	et	et	PROPN
ecj-12310	107	23	al	al	PROPN
ecj-12310	107	24	.	.	PUNCT
ecj-12310	108	1	the	the	DET
ecj-12310	108	2	first	first	ADJ
ecj-12310	108	3	group	group	NOUN
ecj-12310	108	4	received	receive	VERB
ecj-12310	108	5	mannitol	mannitol	NOUN
ecj-12310	108	6	,	,	PUNCT
ecj-12310	108	7	the	the	DET
ecj-12310	108	8	following	follow	VERB
ecj-12310	108	9	one	one	NUM
ecj-12310	108	10	received	receive	VERB
ecj-12310	108	11	mannitol+hts	mannitol+ht	NOUN
ecj-12310	108	12	,	,	PUNCT
ecj-12310	108	13	and	and	CCONJ
ecj-12310	108	14	the	the	DET
ecj-12310	108	15	third	third	ADJ
ecj-12310	108	16	group	group	NOUN
ecj-12310	108	17	received	receive	VERB
ecj-12310	108	18	solely	solely	ADV
ecj-12310	108	19	hts	ht	NOUN
ecj-12310	108	20	and	and	CCONJ
ecj-12310	108	21	the	the	DET
ecj-12310	108	22	treatment	treatment	NOUN
ecj-12310	108	23	continued	continue	VERB
ecj-12310	108	24	for	for	ADP
ecj-12310	108	25	72	72	NUM
ecj-12310	108	26	hours	hour	NOUN
ecj-12310	108	27	,	,	PUNCT
ecj-12310	108	28	utilizing	utilize	VERB
ecj-12310	108	29	boluses	bolus	NOUN
ecj-12310	108	30	three	three	NUM
ecj-12310	108	31	times	time	NOUN
ecj-12310	108	32	each	each	DET
ecj-12310	108	33	day	day	NOUN
ecj-12310	108	34	.	.	PUNCT
ecj-12310	109	1	they	they	PRON
ecj-12310	109	2	concluded	conclude	VERB
ecj-12310	109	3	that	that	SCONJ
ecj-12310	109	4	hts	hts	PROPN
ecj-12310	109	5	is	be	AUX
ecj-12310	109	6	a	a	DET
ecj-12310	109	7	viable	viable	ADJ
ecj-12310	109	8	option	option	NOUN
ecj-12310	109	9	for	for	ADP
ecj-12310	109	10	decreasing	decrease	VERB
ecj-12310	109	11	icp	icp	PROPN
ecj-12310	109	12	in	in	ADP
ecj-12310	109	13	humans	human	NOUN
ecj-12310	109	14	without	without	ADP
ecj-12310	109	15	affecting	affect	VERB
ecj-12310	109	16	cvp	cvp	NOUN
ecj-12310	109	17	or	or	CCONJ
ecj-12310	109	18	serum	serum	NOUN
ecj-12310	109	19	osmolality	osmolality	NOUN
ecj-12310	109	20	.	.	PUNCT
ecj-12310	110	1	it	it	PRON
ecj-12310	110	2	is	be	AUX
ecj-12310	110	3	unlikely	unlikely	ADJ
ecj-12310	110	4	to	to	PART
ecj-12310	110	5	cause	cause	VERB
ecj-12310	110	6	allergic	allergic	ADJ
ecj-12310	110	7	responses	response	NOUN
ecj-12310	110	8	or	or	CCONJ
ecj-12310	110	9	to	to	PART
ecj-12310	110	10	transfer	transfer	VERB
ecj-12310	110	11	infectious	infectious	ADJ
ecj-12310	110	12	agents	agent	NOUN
ecj-12310	110	13	,	,	PUNCT
ecj-12310	110	14	and	and	CCONJ
ecj-12310	110	15	it	it	PRON
ecj-12310	110	16	is	be	AUX
ecj-12310	110	17	readily	readily	ADV
ecj-12310	110	18	managed	manage	VERB
ecj-12310	110	19	by	by	ADP
ecj-12310	110	20	serum	serum	NOUN
ecj-12310	110	21	na	na	NOUN
ecj-12310	110	22	levels	level	NOUN
ecj-12310	110	23	.	.	PUNCT
ecj-12310	111	1	in	in	ADP
ecj-12310	111	2	intracranial	intracranial	ADJ
ecj-12310	111	3	surgery	surgery	NOUN
ecj-12310	111	4	,	,	PUNCT
ecj-12310	111	5	it	it	PRON
ecj-12310	111	6	is	be	AUX
ecj-12310	111	7	an	an	DET
ecj-12310	111	8	acceptable	acceptable	ADJ
ecj-12310	111	9	substitution	substitution	NOUN
ecj-12310	111	10	for	for	ADP
ecj-12310	111	11	mannitol.56	mannitol.56	NOUN
ecj-12310	111	12	following	follow	VERB
ecj-12310	111	13	elective	elective	ADJ
ecj-12310	111	14	craniotomy	craniotomy	NOUN
ecj-12310	111	15	,	,	PUNCT
ecj-12310	111	16	mannitol	mannitol	NOUN
ecj-12310	111	17	,	,	PUNCT
ecj-12310	111	18	and	and	CCONJ
ecj-12310	111	19	hts	hts	PROPN
ecj-12310	111	20	enhance	enhance	VERB
ecj-12310	111	21	csf	csf	ADJ
ecj-12310	111	22	osmolality	osmolality	NOUN
ecj-12310	111	23	and	and	CCONJ
ecj-12310	111	24	are	be	AUX
ecj-12310	111	25	associated	associate	VERB
ecj-12310	111	26	with	with	ADP
ecj-12310	111	27	comparable	comparable	ADJ
ecj-12310	111	28	levels	level	NOUN
ecj-12310	111	29	of	of	ADP
ecj-12310	111	30	cerebral	cerebral	ADJ
ecj-12310	111	31	relaxation	relaxation	NOUN
ecj-12310	111	32	,	,	PUNCT
ecj-12310	111	33	arteriovenous	arteriovenous	ADJ
ecj-12310	111	34	o2	o2	PROPN
ecj-12310	111	35	differential	differential	NOUN
ecj-12310	111	36	,	,	PUNCT
ecj-12310	111	37	and	and	CCONJ
ecj-12310	111	38	lactate	lactate	NOUN
ecj-12310	111	39	.	.	PUNCT
ecj-12310	112	1	they	they	PRON
ecj-12310	112	2	propose	propose	VERB
ecj-12310	112	3	that	that	SCONJ
ecj-12310	112	4	hts	hts	PROPN
ecj-12310	112	5	should	should	AUX
ecj-12310	112	6	be	be	AUX
ecj-12310	112	7	employed	employ	VERB
ecj-12310	112	8	instead	instead	ADV
ecj-12310	112	9	of	of	ADP
ecj-12310	112	10	mannitol	mannitol	NOUN
ecj-12310	112	11	to	to	PART
ecj-12310	112	12	reduce	reduce	VERB
ecj-12310	112	13	brain	brain	NOUN
ecj-12310	112	14	size	size	NOUN
ecj-12310	112	15	in	in	ADP
ecj-12310	112	16	patients	patient	NOUN
ecj-12310	112	17	with	with	ADP
ecj-12310	112	18	and	and	CCONJ
ecj-12310	112	19	without	without	ADP
ecj-12310	112	20	subarachnoid	subarachnoid	NOUN
ecj-12310	112	21	hemorrhage	hemorrhage	NOUN
ecj-12310	112	22	,	,	PUNCT
ecj-12310	112	23	especially	especially	ADV
ecj-12310	112	24	if	if	SCONJ
ecj-12310	112	25	they	they	PRON
ecj-12310	112	26	are	be	AUX
ecj-12310	112	27	hemodynamically	hemodynamically	ADV
ecj-12310	112	28	unstable.57	unstable.57	ADJ
ecj-12310	112	29	resuscitation	resuscitation	NOUN
ecj-12310	112	30	with	with	ADP
ecj-12310	112	31	fluids	fluid	NOUN
ecj-12310	112	32	is	be	AUX
ecj-12310	112	33	crucial	crucial	ADJ
ecj-12310	112	34	in	in	ADP
ecj-12310	112	35	tbi	tbi	NOUN
ecj-12310	112	36	patients	patient	NOUN
ecj-12310	112	37	because	because	SCONJ
ecj-12310	112	38	it	it	PRON
ecj-12310	112	39	prevents	prevent	VERB
ecj-12310	112	40	hypotension	hypotension	NOUN
ecj-12310	112	41	and	and	CCONJ
ecj-12310	112	42	subsequent	subsequent	ADJ
ecj-12310	112	43	brain	brain	NOUN
ecj-12310	112	44	damage	damage	NOUN
ecj-12310	112	45	,	,	PUNCT
ecj-12310	112	46	both	both	PRON
ecj-12310	112	47	of	of	ADP
ecj-12310	112	48	which	which	PRON
ecj-12310	112	49	increase	increase	VERB
ecj-12310	112	50	mortality	mortality	NOUN
ecj-12310	112	51	.	.	PUNCT
ecj-12310	113	1	the	the	DET
ecj-12310	113	2	brain	brain	NOUN
ecj-12310	113	3	trauma	trauma	PROPN
ecj-12310	113	4	foundation	foundation	PROPN
ecj-12310	113	5	’s	’s	PART
ecj-12310	113	6	care	care	NOUN
ecj-12310	113	7	recommendations	recommendation	NOUN
ecj-12310	113	8	for	for	ADP
ecj-12310	113	9	tbi	tbi	PROPN
ecj-12310	113	10	state	state	NOUN
ecj-12310	113	11	unequivocally	unequivocally	ADV
ecj-12310	113	12	that	that	SCONJ
ecj-12310	113	13	hypotension	hypotension	NOUN
ecj-12310	113	14	must	must	AUX
ecj-12310	113	15	be	be	AUX
ecj-12310	113	16	avoided	avoid	VERB
ecj-12310	113	17	since	since	SCONJ
ecj-12310	113	18	it	it	PRON
ecj-12310	113	19	is	be	AUX
ecj-12310	113	20	an	an	DET
ecj-12310	113	21	independent	independent	ADJ
ecj-12310	113	22	characteristic	characteristic	NOUN
ecj-12310	113	23	of	of	ADP
ecj-12310	113	24	poor	poor	ADJ
ecj-12310	113	25	prognosis	prognosis	NOUN
ecj-12310	113	26	.	.	PUNCT
ecj-12310	114	1	the	the	DET
ecj-12310	114	2	administration	administration	NOUN
ecj-12310	114	3	of	of	ADP
ecj-12310	114	4	fluids	fluid	NOUN
ecj-12310	114	5	in	in	ADP
ecj-12310	114	6	this	this	DET
ecj-12310	114	7	patient	patient	NOUN
ecj-12310	114	8	,	,	PUNCT
ecj-12310	114	9	particularly	particularly	ADV
ecj-12310	114	10	with	with	ADP
ecj-12310	114	11	hts	ht	NOUN
ecj-12310	114	12	alone	alone	ADV
ecj-12310	114	13	or	or	CCONJ
ecj-12310	114	14	in	in	ADP
ecj-12310	114	15	combination	combination	NOUN
ecj-12310	114	16	with	with	ADP
ecj-12310	114	17	dextran	dextran	NOUN
ecj-12310	114	18	,	,	PUNCT
ecj-12310	114	19	restores	restore	VERB
ecj-12310	114	20	intravascular	intravascular	ADJ
ecj-12310	114	21	volume	volume	NOUN
ecj-12310	114	22	with	with	ADP
ecj-12310	114	23	less	less	ADJ
ecj-12310	114	24	volume,58	volume,58	NOUN
ecj-12310	114	25	raises	raise	VERB
ecj-12310	114	26	cpp	cpp	NOUN
ecj-12310	114	27	,	,	PUNCT
ecj-12310	114	28	decreases	decrease	VERB
ecj-12310	114	29	icp,59	icp,59	NOUN
ecj-12310	114	30	and	and	CCONJ
ecj-12310	114	31	regulates	regulate	VERB
ecj-12310	114	32	the	the	DET
ecj-12310	114	33	inflammatory	inflammatory	ADJ
ecj-12310	114	34	response.60	response.60	NOUN
ecj-12310	114	35	-	-	PUNCT
ecj-12310	114	36	67	67	NUM
ecj-12310	114	37	the	the	DET
ecj-12310	114	38	beneficial	beneficial	ADJ
ecj-12310	114	39	effect	effect	NOUN
ecj-12310	114	40	of	of	ADP
ecj-12310	114	41	hts	hts	PROPN
ecj-12310	114	42	over	over	ADP
ecj-12310	114	43	mannitol	mannitol	NOUN
ecj-12310	114	44	in	in	ADP
ecj-12310	114	45	terms	term	NOUN
ecj-12310	114	46	of	of	ADP
ecj-12310	114	47	potential	potential	ADJ
ecj-12310	114	48	longterm	longterm	ADJ
ecj-12310	114	49	neurological	neurological	ADJ
ecj-12310	114	50	consequences	consequence	NOUN
ecj-12310	114	51	is	be	AUX
ecj-12310	114	52	still	still	ADV
ecj-12310	114	53	unknown	unknown	ADJ
ecj-12310	114	54	.	.	PUNCT
ecj-12310	115	1	to	to	PART
ecj-12310	115	2	solve	solve	VERB
ecj-12310	115	3	this	this	DET
ecj-12310	115	4	topic	topic	NOUN
ecj-12310	115	5	,	,	PUNCT
ecj-12310	115	6	a	a	DET
ecj-12310	115	7	substantial	substantial	ADJ
ecj-12310	115	8	prospective	prospective	ADJ
ecj-12310	115	9	randomized	randomized	ADJ
ecj-12310	115	10	investigation	investigation	NOUN
ecj-12310	115	11	is	be	AUX
ecj-12310	115	12	required	require	VERB
ecj-12310	115	13	.	.	PUNCT
ecj-12310	116	1	many	many	ADJ
ecj-12310	116	2	of	of	ADP
ecj-12310	116	3	the	the	DET
ecj-12310	116	4	issues	issue	NOUN
ecj-12310	116	5	have	have	VERB
ecj-12310	116	6	yet	yet	ADV
ecj-12310	116	7	to	to	PART
ecj-12310	116	8	be	be	AUX
ecj-12310	116	9	resolved	resolve	VERB
ecj-12310	116	10	,	,	PUNCT
ecj-12310	116	11	necessitating	necessitate	VERB
ecj-12310	116	12	more	more	ADJ
ecj-12310	116	13	studies	study	NOUN
ecj-12310	116	14	to	to	PART
ecj-12310	116	15	reach	reach	VERB
ecj-12310	116	16	a	a	DET
ecj-12310	116	17	firm	firm	ADJ
ecj-12310	116	18	judgment	judgment	NOUN
ecj-12310	116	19	on	on	ADP
ecj-12310	116	20	the	the	DET
ecj-12310	116	21	supremacy	supremacy	NOUN
ecj-12310	116	22	of	of	ADP
ecj-12310	116	23	these	these	DET
ecj-12310	116	24	hyperosmolar	hyperosmolar	ADJ
ecj-12310	116	25	drugs	drug	NOUN
ecj-12310	116	26	.	.	PUNCT
ecj-12310	117	1	evidence	evidence	NOUN
ecj-12310	117	2	linking	link	VERB
ecj-12310	117	3	management	management	NOUN
ecj-12310	117	4	of	of	ADP
ecj-12310	117	5	cerebral	cerebral	ADJ
ecj-12310	117	6	edema	edema	NOUN
ecj-12310	117	7	in	in	ADP
ecj-12310	117	8	traumatic	traumatic	ADJ
ecj-12310	117	9	brain	brain	NOUN
ecj-12310	117	10	injury	injury	NOUN
ecj-12310	117	11	there	there	PRON
ecj-12310	117	12	have	have	AUX
ecj-12310	117	13	been	be	AUX
ecj-12310	117	14	few	few	ADJ
ecj-12310	117	15	research	research	NOUN
ecj-12310	117	16	that	that	PRON
ecj-12310	117	17	compare	compare	VERB
ecj-12310	117	18	mannitol	mannitol	NOUN
ecj-12310	117	19	with	with	ADP
ecj-12310	117	20	hts	hts	PROPN
ecj-12310	117	21	in	in	ADP
ecj-12310	117	22	the	the	DET
ecj-12310	117	23	context	context	NOUN
ecj-12310	117	24	of	of	ADP
ecj-12310	117	25	pure	pure	ADJ
ecj-12310	117	26	cerebral	cerebral	ADJ
ecj-12310	117	27	relaxation	relaxation	NOUN
ecj-12310	117	28	in	in	ADP
ecj-12310	117	29	tumors	tumor	NOUN
ecj-12310	117	30	.	.	PUNCT
ecj-12310	118	1	de	de	ADV
ecj-12310	118	2	vivo	vivo	NOUN
ecj-12310	118	3	et	et	PROPN
ecj-12310	118	4	al	al	PROPN
ecj-12310	118	5	.	.	PROPN
ecj-12310	118	6	undertook	undertake	VERB
ecj-12310	118	7	a	a	DET
ecj-12310	118	8	prospective	prospective	ADJ
ecj-12310	118	9	,	,	PUNCT
ecj-12310	118	10	randomized	randomize	VERB
ecj-12310	118	11	comparative	comparative	ADJ
ecj-12310	118	12	analysis	analysis	NOUN
ecj-12310	118	13	of	of	ADP
ecj-12310	118	14	supratentorial	supratentorial	ADJ
ecj-12310	118	15	tumors	tumor	NOUN
ecj-12310	118	16	.	.	PUNCT
ecj-12310	119	1	the	the	DET
ecj-12310	119	2	study	study	NOUN
ecj-12310	119	3	concluded	conclude	VERB
ecj-12310	119	4	that	that	SCONJ
ecj-12310	119	5	hts	hts	PROPN
ecj-12310	119	6	is	be	AUX
ecj-12310	119	7	an	an	DET
ecj-12310	119	8	efficient	efficient	ADJ
ecj-12310	119	9	way	way	NOUN
ecj-12310	119	10	to	to	PART
ecj-12310	119	11	reduce	reduce	VERB
ecj-12310	119	12	icp	icp	PROPN
ecj-12310	119	13	in	in	ADP
ecj-12310	119	14	people	people	NOUN
ecj-12310	119	15	without	without	ADP
ecj-12310	119	16	affecting	affect	VERB
ecj-12310	119	17	cvp	cvp	NOUN
ecj-12310	119	18	or	or	CCONJ
ecj-12310	119	19	serum	serum	NOUN
ecj-12310	119	20	osmolality	osmolality	NOUN
ecj-12310	119	21	.	.	PUNCT
ecj-12310	120	1	it	it	PRON
ecj-12310	120	2	is	be	AUX
ecj-12310	120	3	unlikely	unlikely	ADJ
ecj-12310	120	4	to	to	PART
ecj-12310	120	5	cause	cause	VERB
ecj-12310	120	6	anaphylaxis	anaphylaxis	ADJ
ecj-12310	120	7	or	or	CCONJ
ecj-12310	120	8	spread	spread	VERB
ecj-12310	120	9	infectious	infectious	ADJ
ecj-12310	120	10	agents	agent	NOUN
ecj-12310	120	11	,	,	PUNCT
ecj-12310	120	12	and	and	CCONJ
ecj-12310	120	13	serum	serum	NOUN
ecj-12310	120	14	na	na	PROPN
ecj-12310	120	15	levels	level	NOUN
ecj-12310	120	16	can	can	AUX
ecj-12310	120	17	readily	readily	ADV
ecj-12310	120	18	regulate	regulate	VERB
ecj-12310	120	19	it	it	PRON
ecj-12310	120	20	.	.	PUNCT
ecj-12310	121	1	it	it	PRON
ecj-12310	121	2	is	be	AUX
ecj-12310	121	3	a	a	DET
ecj-12310	121	4	viable	viable	ADJ
ecj-12310	121	5	alternative	alternative	NOUN
ecj-12310	121	6	to	to	ADP
ecj-12310	121	7	mannitol	mannitol	NOUN
ecj-12310	121	8	in	in	ADP
ecj-12310	121	9	intracranial	intracranial	ADJ
ecj-12310	121	10	surgery.68	surgery.68	NOUN
ecj-12310	121	11	several	several	ADJ
ecj-12310	121	12	investigations	investigation	NOUN
ecj-12310	121	13	have	have	AUX
ecj-12310	121	14	examined	examine	VERB
ecj-12310	121	15	the	the	DET
ecj-12310	121	16	cerebral	cerebral	ADJ
ecj-12310	121	17	effects	effect	NOUN
ecj-12310	121	18	of	of	ADP
ecj-12310	121	19	mannitol	mannitol	NOUN
ecj-12310	121	20	and	and	CCONJ
ecj-12310	121	21	hts	hts	PROPN
ecj-12310	121	22	in	in	ADP
ecj-12310	121	23	patients	patient	NOUN
ecj-12310	121	24	with	with	ADP
ecj-12310	121	25	normal	normal	ADJ
ecj-12310	121	26	icp	icp	PROPN
ecj-12310	121	27	.	.	PUNCT
ecj-12310	122	1	gemma	gemma	PROPN
ecj-12310	122	2	et	et	PROPN
ecj-12310	122	3	al	al	PROPN
ecj-12310	122	4	.	.	PROPN
ecj-12310	122	5	found	find	VERB
ecj-12310	122	6	that	that	SCONJ
ecj-12310	122	7	hts	ht	NOUN
ecj-12310	122	8	and	and	CCONJ
ecj-12310	122	9	mannitol	mannitol	NOUN
ecj-12310	122	10	produce	produce	VERB
ecj-12310	122	11	acceptable	acceptable	ADJ
ecj-12310	122	12	cerebral	cerebral	ADJ
ecj-12310	122	13	relaxation	relaxation	NOUN
ecj-12310	122	14	in	in	ADP
ecj-12310	122	15	individuals	individual	NOUN
ecj-12310	122	16	undergoing	undergo	VERB
ecj-12310	122	17	elective	elective	ADJ
ecj-12310	122	18	craniotomy	craniotomy	NOUN
ecj-12310	122	19	.	.	PUNCT
ecj-12310	123	1	this	this	DET
ecj-12310	123	2	investigation	investigation	NOUN
ecj-12310	123	3	was	be	AUX
ecj-12310	123	4	carried	carry	VERB
ecj-12310	123	5	out	out	ADP
ecj-12310	123	6	using	use	VERB
ecj-12310	123	7	several	several	ADJ
ecj-12310	123	8	neurosurgical	neurosurgical	ADJ
ecj-12310	123	9	techniques	technique	NOUN
ecj-12310	123	10	and	and	CCONJ
ecj-12310	123	11	non	non	ADJ
ecj-12310	123	12	-	-	ADJ
ecj-12310	123	13	equimolar	equimolar	ADJ
ecj-12310	123	14	dosages	dosage	NOUN
ecj-12310	123	15	of	of	ADP
ecj-12310	123	16	hts	ht	NOUN
ecj-12310	123	17	and	and	CCONJ
ecj-12310	123	18	mannitol.69	mannitol.69	VERB
ecj-12310	123	19	the	the	DET
ecj-12310	123	20	clinical	clinical	ADJ
ecj-12310	123	21	evidence	evidence	NOUN
ecj-12310	123	22	comparing	compare	VERB
ecj-12310	123	23	hypertonic	hypertonic	ADJ
ecj-12310	123	24	saline	saline	NOUN
ecj-12310	123	25	and	and	CCONJ
ecj-12310	123	26	mannitol	mannitol	NOUN
ecj-12310	123	27	is	be	AUX
ecj-12310	123	28	discussed	discuss	VERB
ecj-12310	123	29	in	in	ADP
ecj-12310	123	30	the	the	DET
ecj-12310	123	31	supplementary	supplementary	ADJ
ecj-12310	123	32	materials	material	NOUN
ecj-12310	123	33	,	,	PUNCT
ecj-12310	123	34	table	table	NOUN
ecj-12310	123	35	1.70	1.70	NUM
ecj-12310	123	36	-	-	SYM
ecj-12310	123	37	77	77	NUM
ecj-12310	123	38	a	a	DET
ecj-12310	123	39	summary	summary	NOUN
ecj-12310	123	40	of	of	ADP
ecj-12310	123	41	the	the	DET
ecj-12310	123	42	comparison	comparison	NOUN
ecj-12310	123	43	of	of	ADP
ecj-12310	123	44	safety	safety	NOUN
ecj-12310	123	45	efficacy	efficacy	NOUN
ecj-12310	123	46	profile	profile	NOUN
ecj-12310	123	47	of	of	ADP
ecj-12310	123	48	mannitol	mannitol	NOUN
ecj-12310	123	49	and	and	CCONJ
ecj-12310	123	50	hypertonic	hypertonic	ADJ
ecj-12310	123	51	saline	saline	NOUN
ecj-12310	123	52	is	be	AUX
ecj-12310	123	53	available	available	ADJ
ecj-12310	123	54	in	in	ADP
ecj-12310	123	55	the	the	DET
ecj-12310	123	56	supplementary	supplementary	ADJ
ecj-12310	123	57	materials	material	NOUN
ecj-12310	123	58	,	,	PUNCT
ecj-12310	123	59	table	table	NOUN
ecj-12310	123	60	2	2	NUM
ecj-12310	123	61	.	.	PUNCT
ecj-12310	123	62	conclusions	conclusion	NOUN
ecj-12310	123	63	the	the	DET
ecj-12310	123	64	significance	significance	NOUN
ecj-12310	123	65	of	of	ADP
ecj-12310	123	66	intracranial	intracranial	ADJ
ecj-12310	123	67	pressure	pressure	NOUN
ecj-12310	123	68	(	(	PUNCT
ecj-12310	123	69	icp	icp	NOUN
ecj-12310	123	70	)	)	PUNCT
ecj-12310	123	71	in	in	ADP
ecj-12310	123	72	managing	manage	VERB
ecj-12310	123	73	conditions	condition	NOUN
ecj-12310	123	74	like	like	ADP
ecj-12310	123	75	traumatic	traumatic	ADJ
ecj-12310	123	76	head	head	NOUN
ecj-12310	123	77	injuries	injury	NOUN
ecj-12310	123	78	and	and	CCONJ
ecj-12310	123	79	various	various	ADJ
ecj-12310	123	80	neurologic	neurologic	ADJ
ecj-12310	123	81	diseases	disease	NOUN
ecj-12310	123	82	can	can	AUX
ecj-12310	123	83	not	not	PART
ecj-12310	123	84	be	be	AUX
ecj-12310	123	85	overstated	overstate	VERB
ecj-12310	123	86	.	.	PUNCT
ecj-12310	124	1	it	it	PRON
ecj-12310	124	2	is	be	AUX
ecj-12310	124	3	crucial	crucial	ADJ
ecj-12310	124	4	to	to	PART
ecj-12310	124	5	recognize	recognize	VERB
ecj-12310	124	6	that	that	SCONJ
ecj-12310	124	7	the	the	DET
ecj-12310	124	8	primary	primary	ADJ
ecj-12310	124	9	objective	objective	NOUN
ecj-12310	124	10	of	of	ADP
ecj-12310	124	11	icp	icp	PROPN
ecj-12310	124	12	management	management	NOUN
ecj-12310	124	13	is	be	AUX
ecj-12310	124	14	to	to	PART
ecj-12310	124	15	optimize	optimize	VERB
ecj-12310	124	16	cerebral	cerebral	ADJ
ecj-12310	124	17	perfusion	perfusion	NOUN
ecj-12310	124	18	pressure	pressure	NOUN
ecj-12310	124	19	(	(	PUNCT
ecj-12310	124	20	cpp	cpp	NOUN
ecj-12310	124	21	)	)	PUNCT
ecj-12310	124	22	for	for	ADP
ecj-12310	124	23	the	the	DET
ecj-12310	124	24	preservation	preservation	NOUN
ecj-12310	124	25	of	of	ADP
ecj-12310	124	26	cerebral	cerebral	ADJ
ecj-12310	124	27	metabolism	metabolism	NOUN
ecj-12310	124	28	and	and	CCONJ
ecj-12310	124	29	neurologic	neurologic	ADJ
ecj-12310	124	30	function	function	NOUN
ecj-12310	124	31	.	.	PUNCT
ecj-12310	125	1	solely	solely	ADV
ecj-12310	125	2	concentrating	concentrate	VERB
ecj-12310	125	3	on	on	ADP
ecj-12310	125	4	icp	icp	PROPN
ecj-12310	125	5	,	,	PUNCT
ecj-12310	125	6	without	without	ADP
ecj-12310	125	7	considering	consider	VERB
ecj-12310	125	8	other	other	ADJ
ecj-12310	125	9	relevant	relevant	ADJ
ecj-12310	125	10	physiologic	physiologic	ADJ
ecj-12310	125	11	variables	variable	NOUN
ecj-12310	125	12	such	such	ADJ
ecj-12310	125	13	as	as	ADP
ecj-12310	125	14	cpp	cpp	NOUN
ecj-12310	125	15	,	,	PUNCT
ecj-12310	125	16	oxygen	oxygen	NOUN
ecj-12310	125	17	utilization	utilization	NOUN
ecj-12310	125	18	,	,	PUNCT
ecj-12310	125	19	and	and	CCONJ
ecj-12310	125	20	clinical	clinical	ADJ
ecj-12310	125	21	outcomes	outcome	NOUN
ecj-12310	125	22	,	,	PUNCT
ecj-12310	125	23	is	be	AUX
ecj-12310	125	24	a	a	DET
ecj-12310	125	25	notable	notable	ADJ
ecj-12310	125	26	flaw	flaw	NOUN
ecj-12310	125	27	in	in	ADP
ecj-12310	125	28	numerous	numerous	ADJ
ecj-12310	125	29	published	publish	VERB
ecj-12310	125	30	randomized	randomize	VERB
ecj-12310	125	31	controlled	control	VERB
ecj-12310	125	32	trials	trial	NOUN
ecj-12310	125	33	(	(	PUNCT
ecj-12310	125	34	rcts	rct	NOUN
ecj-12310	125	35	)	)	PUNCT
ecj-12310	125	36	focusing	focus	VERB
ecj-12310	125	37	on	on	ADP
ecj-12310	125	38	hyperosmolar	hyperosmolar	ADJ
ecj-12310	125	39	therapy	therapy	NOUN
ecj-12310	125	40	.	.	PUNCT
ecj-12310	126	1	regardless	regardless	ADV
ecj-12310	126	2	of	of	ADP
ecj-12310	126	3	the	the	DET
ecj-12310	126	4	specific	specific	ADJ
ecj-12310	126	5	hyperosmolar	hyperosmolar	ADJ
ecj-12310	126	6	agent	agent	NOUN
ecj-12310	126	7	employed	employ	VERB
ecj-12310	126	8	,	,	PUNCT
ecj-12310	126	9	the	the	DET
ecj-12310	126	10	efficacy	efficacy	NOUN
ecj-12310	126	11	of	of	ADP
ecj-12310	126	12	hyperosmolar	hyperosmolar	ADJ
ecj-12310	126	13	therapy	therapy	NOUN
ecj-12310	126	14	for	for	ADP
ecj-12310	126	15	acute	acute	PROPN
ecj-12310	126	16	icp	icp	PROPN
ecj-12310	126	17	management	management	NOUN
ecj-12310	126	18	has	have	AUX
ecj-12310	126	19	been	be	AUX
ecj-12310	126	20	substantiated	substantiate	VERB
ecj-12310	126	21	by	by	ADP
ecj-12310	126	22	both	both	CCONJ
ecj-12310	126	23	clinical	clinical	ADJ
ecj-12310	126	24	experience	experience	NOUN
ecj-12310	126	25	and	and	CCONJ
ecj-12310	126	26	rcts	rct	NOUN
ecj-12310	126	27	.	.	PUNCT
ecj-12310	127	1	mannitol	mannitol	NOUN
ecj-12310	127	2	and	and	CCONJ
ecj-12310	127	3	hs	hs	PROPN
ecj-12310	127	4	are	be	AUX
ecj-12310	127	5	the	the	DET
ecj-12310	127	6	most	most	ADV
ecj-12310	127	7	commonly	commonly	ADV
ecj-12310	127	8	used	use	VERB
ecj-12310	127	9	hyperosmolar	hyperosmolar	ADJ
ecj-12310	127	10	agents	agent	NOUN
ecj-12310	127	11	,	,	PUNCT
ecj-12310	127	12	each	each	PRON
ecj-12310	127	13	with	with	ADP
ecj-12310	127	14	distinct	distinct	ADJ
ecj-12310	127	15	physiologic	physiologic	ADJ
ecj-12310	127	16	properties	property	NOUN
ecj-12310	127	17	affecting	affect	VERB
ecj-12310	127	18	blood	blood	NOUN
ecj-12310	127	19	rheology	rheology	NOUN
ecj-12310	127	20	,	,	PUNCT
ecj-12310	127	21	inflammation	inflammation	NOUN
ecj-12310	127	22	,	,	PUNCT
ecj-12310	127	23	neurochemistry	neurochemistry	NOUN
ecj-12310	127	24	,	,	PUNCT
ecj-12310	127	25	and	and	CCONJ
ecj-12310	127	26	hemodynamic	hemodynamic	ADJ
ecj-12310	127	27	regulation	regulation	NOUN
ecj-12310	127	28	.	.	PUNCT
ecj-12310	128	1	while	while	SCONJ
ecj-12310	128	2	the	the	DET
ecj-12310	128	3	idea	idea	NOUN
ecj-12310	128	4	of	of	ADP
ecj-12310	128	5	a	a	DET
ecj-12310	128	6	universally	universally	ADV
ecj-12310	128	7	applicable	applicable	ADJ
ecj-12310	128	8	,	,	PUNCT
ecj-12310	128	9	single	single	ADJ
ecj-12310	128	10	optimal	optimal	ADJ
ecj-12310	128	11	agent	agent	NOUN
ecj-12310	128	12	is	be	AUX
ecj-12310	128	13	appealing	appealing	ADJ
ecj-12310	128	14	,	,	PUNCT
ecj-12310	128	15	it	it	PRON
ecj-12310	128	16	is	be	AUX
ecj-12310	128	17	more	more	ADV
ecj-12310	128	18	plausible	plausible	ADJ
ecj-12310	128	19	that	that	SCONJ
ecj-12310	128	20	different	different	ADJ
ecj-12310	128	21	hyperosmolar	hyperosmolar	ADJ
ecj-12310	128	22	agents	agent	NOUN
ecj-12310	128	23	may	may	AUX
ecj-12310	128	24	exert	exert	VERB
ecj-12310	128	25	optimal	optimal	ADJ
ecj-12310	128	26	therapeutic	therapeutic	ADJ
ecj-12310	128	27	effects	effect	NOUN
ecj-12310	128	28	in	in	ADP
ecj-12310	128	29	diverse	diverse	ADJ
ecj-12310	128	30	clinical	clinical	ADJ
ecj-12310	128	31	contexts	contexts	NOUN
ecj-12310	128	32	.	.	PUNCT
ecj-12310	129	1	for	for	ADP
ecj-12310	129	2	example	example	NOUN
ecj-12310	129	3	,	,	PUNCT
ecj-12310	129	4	the	the	DET
ecj-12310	129	5	relative	relative	ADJ
ecj-12310	129	6	merit	merit	NOUN
ecj-12310	129	7	of	of	ADP
ecj-12310	129	8	using	use	VERB
ecj-12310	129	9	hs	hs	PRON
ecj-12310	129	10	,	,	PUNCT
ecj-12310	129	11	which	which	PRON
ecj-12310	129	12	expands	expand	VERB
ecj-12310	129	13	systemic	systemic	ADJ
ecj-12310	129	14	volume	volume	NOUN
ecj-12310	129	15	status	status	NOUN
ecj-12310	129	16	,	,	PUNCT
ecj-12310	129	17	versus	versus	ADP
ecj-12310	129	18	mannitol	mannitol	NOUN
ecj-12310	129	19	,	,	PUNCT
ecj-12310	129	20	which	which	PRON
ecj-12310	129	21	depletes	deplete	VERB
ecj-12310	129	22	it	it	PRON
ecj-12310	129	23	,	,	PUNCT
ecj-12310	129	24	needs	need	VERB
ecj-12310	129	25	exploration	exploration	NOUN
ecj-12310	129	26	in	in	ADP
ecj-12310	129	27	patients	patient	NOUN
ecj-12310	129	28	with	with	ADP
ecj-12310	129	29	congestive	congestive	ADJ
ecj-12310	129	30	heart	heart	NOUN
ecj-12310	129	31	failure	failure	NOUN
ecj-12310	129	32	experiencing	experience	VERB
ecj-12310	129	33	elevated	elevated	ADJ
ecj-12310	129	34	intracranial	intracranial	ADJ
ecj-12310	129	35	hypertension	hypertension	NOUN
ecj-12310	129	36	.	.	PUNCT
ecj-12310	130	1	trials	trial	NOUN
ecj-12310	130	2	should	should	AUX
ecj-12310	130	3	consider	consider	VERB
ecj-12310	130	4	testing	test	VERB
ecj-12310	130	5	equimolar	equimolar	NOUN
ecj-12310	130	6	agents	agent	NOUN
ecj-12310	130	7	infused	infuse	VERB
ecj-12310	130	8	over	over	ADP
ecj-12310	130	9	the	the	DET
ecj-12310	130	10	same	same	ADJ
ecj-12310	130	11	period	period	NOUN
ecj-12310	130	12	to	to	PART
ecj-12310	130	13	mitigate	mitigate	VERB
ecj-12310	130	14	the	the	DET
ecj-12310	130	15	effects	effect	NOUN
ecj-12310	130	16	of	of	ADP
ecj-12310	130	17	molarity	molarity	NOUN
ecj-12310	130	18	and	and	CCONJ
ecj-12310	130	19	infusion	infusion	NOUN
ecj-12310	130	20	time	time	NOUN
ecj-12310	130	21	,	,	PUNCT
ecj-12310	130	22	a	a	DET
ecj-12310	130	23	consideration	consideration	NOUN
ecj-12310	130	24	often	often	ADV
ecj-12310	130	25	absent	absent	ADJ
ecj-12310	130	26	in	in	ADP
ecj-12310	130	27	existing	exist	VERB
ecj-12310	130	28	literature	literature	NOUN
ecj-12310	130	29	.	.	PUNCT
ecj-12310	131	1	in	in	ADP
ecj-12310	131	2	conclusion	conclusion	NOUN
ecj-12310	131	3	,	,	PUNCT
ecj-12310	131	4	a	a	DET
ecj-12310	131	5	thoughtful	thoughtful	ADJ
ecj-12310	131	6	analysis	analysis	NOUN
ecj-12310	131	7	of	of	ADP
ecj-12310	131	8	individual	individual	ADJ
ecj-12310	131	9	clinical	clinical	ADJ
ecj-12310	131	10	scenarios	scenario	NOUN
ecj-12310	131	11	,	,	PUNCT
ecj-12310	131	12	coupled	couple	VERB
ecj-12310	131	13	with	with	ADP
ecj-12310	131	14	a	a	DET
ecj-12310	131	15	rigorous	rigorous	ADJ
ecj-12310	131	16	interpretation	interpretation	NOUN
ecj-12310	131	17	review	review	NOUN
ecj-12310	131	18	[	[	X
ecj-12310	131	19	emergency	emergency	NOUN
ecj-12310	131	20	care	care	NOUN
ecj-12310	131	21	journal	journal	PROPN
ecj-12310	131	22	2024	2024	NUM
ecj-12310	131	23	;	;	PUNCT
ecj-12310	131	24	20:12310	20:12310	NUM
ecj-12310	131	25	]	]	X
ecj-12310	132	1	[	[	X
ecj-12310	132	2	page	page	NOUN
ecj-12310	132	3	34	34	NUM
ecj-12310	132	4	]	]	X
ecj-12310	132	5	non	non	ADJ
ecj-12310	132	6	-co	-co	PROPN
ecj-12310	132	7	mmerc	mmerc	PROPN
ecj-12310	132	8	ial	ial	PROPN
ecj-12310	132	9	us	us	PROPN
ecj-12310	132	10	e	e	NOUN
ecj-12310	132	11	o	o	NOUN
ecj-12310	132	12	nly	nly	ADV
ecj-12310	132	13	of	of	ADP
ecj-12310	132	14	existing	exist	VERB
ecj-12310	132	15	literature	literature	NOUN
ecj-12310	132	16	,	,	PUNCT
ecj-12310	132	17	is	be	AUX
ecj-12310	132	18	essential	essential	ADJ
ecj-12310	132	19	for	for	ADP
ecj-12310	132	20	providing	provide	VERB
ecj-12310	132	21	optimal	optimal	ADJ
ecj-12310	132	22	patient	patient	ADJ
ecj-12310	132	23	care	care	NOUN
ecj-12310	132	24	.	.	PUNCT
ecj-12310	133	1	references	reference	NOUN
ecj-12310	133	2	1	1	NUM
ecj-12310	133	3	.	.	PUNCT
ecj-12310	133	4	mangat	mangat	PROPN
ecj-12310	133	5	hs	hs	PROPN
ecj-12310	133	6	,	,	PUNCT
ecj-12310	133	7	wu	wu	PROPN
ecj-12310	133	8	x	x	PROPN
ecj-12310	133	9	,	,	PUNCT
ecj-12310	133	10	gerber	gerber	PROPN
ecj-12310	133	11	lm	lm	PROPN
ecj-12310	133	12	,	,	PUNCT
ecj-12310	133	13	et	et	PROPN
ecj-12310	133	14	al	al	PROPN
ecj-12310	133	15	.	.	PUNCT
ecj-12310	134	1	hypertonic	hypertonic	ADJ
ecj-12310	134	2	saline	saline	NOUN
ecj-12310	134	3	is	be	AUX
ecj-12310	134	4	superior	superior	ADJ
ecj-12310	134	5	to	to	ADP
ecj-12310	134	6	mannitol	mannitol	NOUN
ecj-12310	134	7	for	for	ADP
ecj-12310	134	8	the	the	DET
ecj-12310	134	9	combined	combined	ADJ
ecj-12310	134	10	effect	effect	NOUN
ecj-12310	134	11	on	on	ADP
ecj-12310	134	12	intracranial	intracranial	ADJ
ecj-12310	134	13	pressure	pressure	NOUN
ecj-12310	134	14	and	and	CCONJ
ecj-12310	134	15	cerebral	cerebral	ADJ
ecj-12310	134	16	perfusion	perfusion	NOUN
ecj-12310	134	17	pressure	pressure	NOUN
ecj-12310	134	18	burdens	burden	NOUN
ecj-12310	134	19	in	in	ADP
ecj-12310	134	20	patients	patient	NOUN
ecj-12310	134	21	with	with	ADP
ecj-12310	134	22	severe	severe	ADJ
ecj-12310	134	23	traumatic	traumatic	ADJ
ecj-12310	134	24	brain	brain	NOUN
ecj-12310	134	25	injury	injury	NOUN
ecj-12310	134	26	.	.	PUNCT
ecj-12310	135	1	neurosurgery	neurosurgery	PROPN
ecj-12310	135	2	2020;86:22130	2020;86:22130	NUM
ecj-12310	135	3	.	.	PROPN
ecj-12310	136	1	2	2	NUM
ecj-12310	136	2	.	.	X
ecj-12310	136	3	dewan	dewan	PROPN
ecj-12310	136	4	mc	mc	PROPN
ecj-12310	136	5	,	,	PUNCT
ecj-12310	136	6	rattani	rattani	PROPN
ecj-12310	136	7	a	a	PROPN
ecj-12310	136	8	,	,	PUNCT
ecj-12310	136	9	gupta	gupta	PROPN
ecj-12310	136	10	s	s	PART
ecj-12310	136	11	,	,	PUNCT
ecj-12310	136	12	et	et	PROPN
ecj-12310	136	13	al	al	PROPN
ecj-12310	136	14	.	.	PUNCT
ecj-12310	137	1	estimating	estimate	VERB
ecj-12310	137	2	the	the	DET
ecj-12310	137	3	global	global	ADJ
ecj-12310	137	4	incidence	incidence	NOUN
ecj-12310	137	5	of	of	ADP
ecj-12310	137	6	traumatic	traumatic	ADJ
ecj-12310	137	7	brain	brain	NOUN
ecj-12310	137	8	injury	injury	NOUN
ecj-12310	137	9	.	.	PUNCT
ecj-12310	138	1	j	j	PROPN
ecj-12310	138	2	neurosurg	neurosurg	PROPN
ecj-12310	138	3	2019;130:1080–97	2019;130:1080–97	NUM
ecj-12310	138	4	.	.	PUNCT
ecj-12310	139	1	3	3	X
ecj-12310	139	2	.	.	X
ecj-12310	139	3	shi	shi	PROPN
ecj-12310	139	4	j	j	PROPN
ecj-12310	139	5	,	,	PUNCT
ecj-12310	139	6	tan	tan	PROPN
ecj-12310	139	7	l	l	NOUN
ecj-12310	139	8	,	,	PUNCT
ecj-12310	139	9	ye	ye	PROPN
ecj-12310	139	10	j	j	PROPN
ecj-12310	139	11	,	,	PUNCT
ecj-12310	139	12	hu	hu	PROPN
ecj-12310	139	13	l.	l.	PROPN
ecj-12310	139	14	hypertonic	hypertonic	PROPN
ecj-12310	139	15	saline	saline	NOUN
ecj-12310	139	16	and	and	CCONJ
ecj-12310	139	17	mannitol	mannitol	NOUN
ecj-12310	139	18	in	in	ADP
ecj-12310	139	19	patients	patient	NOUN
ecj-12310	139	20	with	with	ADP
ecj-12310	139	21	traumatic	traumatic	ADJ
ecj-12310	139	22	brain	brain	NOUN
ecj-12310	139	23	injury	injury	NOUN
ecj-12310	139	24	:	:	PUNCT
ecj-12310	139	25	a	a	DET
ecj-12310	139	26	systematic	systematic	ADJ
ecj-12310	139	27	and	and	CCONJ
ecj-12310	139	28	metaanalysis	metaanalysis	NOUN
ecj-12310	139	29	.	.	PUNCT
ecj-12310	140	1	medicine	medicine	NOUN
ecj-12310	140	2	(	(	PUNCT
ecj-12310	140	3	baltimore	baltimore	PROPN
ecj-12310	140	4	)	)	PUNCT
ecj-12310	140	5	2020;99	2020;99	NUM
ecj-12310	140	6	:	:	PUNCT
ecj-12310	140	7	e21655	e21655	NOUN
ecj-12310	140	8	.	.	PUNCT
ecj-12310	141	1	4	4	X
ecj-12310	141	2	.	.	X
ecj-12310	141	3	schizodimos	schizodimos	PROPN
ecj-12310	141	4	t	t	PROPN
ecj-12310	141	5	,	,	PUNCT
ecj-12310	141	6	soulountsi	soulountsi	PROPN
ecj-12310	141	7	v	v	NOUN
ecj-12310	141	8	,	,	PUNCT
ecj-12310	141	9	iasonidou	iasonidou	ADJ
ecj-12310	141	10	c	c	NOUN
ecj-12310	141	11	,	,	PUNCT
ecj-12310	141	12	kapravelos	kapravelos	PROPN
ecj-12310	141	13	n.	n.	VERB
ecj-12310	141	14	an	an	DET
ecj-12310	141	15	overview	overview	NOUN
ecj-12310	141	16	of	of	ADP
ecj-12310	141	17	management	management	NOUN
ecj-12310	141	18	of	of	ADP
ecj-12310	141	19	intracranial	intracranial	ADJ
ecj-12310	141	20	hypertension	hypertension	NOUN
ecj-12310	141	21	in	in	ADP
ecj-12310	141	22	the	the	DET
ecj-12310	141	23	intensive	intensive	ADJ
ecj-12310	141	24	care	care	NOUN
ecj-12310	141	25	unit	unit	NOUN
ecj-12310	141	26	.	.	PUNCT
ecj-12310	142	1	j	j	PROPN
ecj-12310	142	2	anesth	anesth	VERB
ecj-12310	142	3	2020;34:741	2020;34:741	NOUN
ecj-12310	142	4	-	-	SYM
ecj-12310	142	5	57	57	NUM
ecj-12310	142	6	.	.	PUNCT
ecj-12310	143	1	5	5	NUM
ecj-12310	143	2	.	.	X
ecj-12310	143	3	mayer	mayer	PROPN
ecj-12310	143	4	sa	sa	PROPN
ecj-12310	143	5	,	,	PUNCT
ecj-12310	143	6	chong	chong	PROPN
ecj-12310	143	7	jy	jy	PROPN
ecj-12310	143	8	.	.	PROPN
ecj-12310	144	1	critical	critical	ADJ
ecj-12310	144	2	care	care	NOUN
ecj-12310	144	3	management	management	NOUN
ecj-12310	144	4	of	of	ADP
ecj-12310	144	5	increased	increase	VERB
ecj-12310	144	6	intracranial	intracranial	ADJ
ecj-12310	144	7	pressure	pressure	NOUN
ecj-12310	144	8	.	.	PUNCT
ecj-12310	145	1	j	j	PROPN
ecj-12310	145	2	intens	inten	NOUN
ecj-12310	145	3	care	care	VERB
ecj-12310	145	4	med	med	ADJ
ecj-12310	145	5	2002;17:55	2002;17:55	PROPN
ecj-12310	145	6	-	-	SYM
ecj-12310	145	7	67	67	NUM
ecj-12310	145	8	.	.	NOUN
ecj-12310	146	1	6	6	NUM
ecj-12310	146	2	.	.	X
ecj-12310	146	3	pinto	pinto	NOUN
ecj-12310	146	4	vl	vl	PROPN
ecj-12310	146	5	,	,	PUNCT
ecj-12310	146	6	tadi	tadi	NOUN
ecj-12310	146	7	p	p	NOUN
ecj-12310	146	8	,	,	PUNCT
ecj-12310	146	9	adeyinka	adeyinka	PROPN
ecj-12310	146	10	a.	a.	NOUN
ecj-12310	146	11	increased	increase	VERB
ecj-12310	146	12	intracranial	intracranial	ADJ
ecj-12310	146	13	pressure	pressure	NOUN
ecj-12310	146	14	.	.	PUNCT
ecj-12310	147	1	in	in	ADP
ecj-12310	147	2	:	:	PUNCT
ecj-12310	147	3	statpearls	statpearl	NOUN
ecj-12310	147	4	.	.	PUNCT
ecj-12310	148	1	statpearls	statpearls	PROPN
ecj-12310	148	2	publishing	publishing	NOUN
ecj-12310	148	3	,	,	PUNCT
ecj-12310	148	4	treasure	treasure	NOUN
ecj-12310	148	5	island	island	NOUN
ecj-12310	148	6	(	(	PUNCT
ecj-12310	148	7	fl	fl	NOUN
ecj-12310	148	8	)	)	PUNCT
ecj-12310	148	9	;	;	PUNCT
ecj-12310	148	10	2022	2022	NUM
ecj-12310	148	11	.	.	PUNCT
ecj-12310	149	1	pmid	pmid	NOUN
ecj-12310	149	2	:	:	PUNCT
ecj-12310	149	3	29489250	29489250	NUM
ecj-12310	149	4	.	.	PUNCT
ecj-12310	150	1	7	7	X
ecj-12310	150	2	.	.	X
ecj-12310	150	3	sharma	sharma	PROPN
ecj-12310	150	4	s	s	PROPN
ecj-12310	150	5	,	,	PUNCT
ecj-12310	150	6	hashmi	hashmi	PROPN
ecj-12310	150	7	mf	mf	PROPN
ecj-12310	150	8	,	,	PUNCT
ecj-12310	150	9	kumar	kumar	PROPN
ecj-12310	150	10	a.	a.	NOUN
ecj-12310	150	11	intracranial	intracranial	PROPN
ecj-12310	150	12	hypertension	hypertension	NOUN
ecj-12310	150	13	.	.	PUNCT
ecj-12310	151	1	2023	2023	NUM
ecj-12310	151	2	may	may	AUX
ecj-12310	151	3	8	8	NUM
ecj-12310	151	4	.	.	PUNCT
ecj-12310	152	1	in	in	ADP
ecj-12310	152	2	:	:	PUNCT
ecj-12310	152	3	statpearls	statpearl	NOUN
ecj-12310	153	1	[	[	X
ecj-12310	153	2	internet	internet	NOUN
ecj-12310	153	3	]	]	PUNCT
ecj-12310	153	4	.	.	PUNCT
ecj-12310	154	1	treasure	treasure	NOUN
ecj-12310	154	2	island	island	NOUN
ecj-12310	154	3	(	(	PUNCT
ecj-12310	154	4	fl	fl	PROPN
ecj-12310	154	5	):	):	PUNCT
ecj-12310	154	6	statpearls	statpearl	NOUN
ecj-12310	154	7	publishing	publishing	NOUN
ecj-12310	154	8	;	;	PUNCT
ecj-12310	154	9	2023	2023	NUM
ecj-12310	154	10	jan–.	jan–.	PUNCT
ecj-12310	155	1	pmid	pmid	NOUN
ecj-12310	155	2	:	:	PUNCT
ecj-12310	155	3	29939588	29939588	NUM
ecj-12310	155	4	.	.	PUNCT
ecj-12310	156	1	8	8	NUM
ecj-12310	156	2	.	.	X
ecj-12310	156	3	scalfani	scalfani	PROPN
ecj-12310	156	4	mt	mt	PROPN
ecj-12310	156	5	,	,	PUNCT
ecj-12310	156	6	dhar	dhar	PROPN
ecj-12310	156	7	r	r	PROPN
ecj-12310	156	8	,	,	PUNCT
ecj-12310	156	9	zazulia	zazulia	PROPN
ecj-12310	156	10	ar	ar	PROPN
ecj-12310	156	11	,	,	PUNCT
ecj-12310	156	12	et	et	PROPN
ecj-12310	156	13	al	al	PROPN
ecj-12310	156	14	.	.	PROPN
ecj-12310	156	15	effect	effect	NOUN
ecj-12310	156	16	of	of	ADP
ecj-12310	156	17	osmotic	osmotic	ADJ
ecj-12310	156	18	agents	agent	NOUN
ecj-12310	156	19	on	on	ADP
ecj-12310	156	20	regional	regional	ADJ
ecj-12310	156	21	cerebral	cerebral	ADJ
ecj-12310	156	22	blood	blood	NOUN
ecj-12310	156	23	flow	flow	NOUN
ecj-12310	156	24	in	in	ADP
ecj-12310	156	25	traumatic	traumatic	ADJ
ecj-12310	156	26	brain	brain	NOUN
ecj-12310	156	27	injury	injury	NOUN
ecj-12310	156	28	.	.	PUNCT
ecj-12310	157	1	j	j	PROPN
ecj-12310	157	2	crit	crit	PROPN
ecj-12310	157	3	care	care	NOUN
ecj-12310	157	4	2012;27:526.e7	2012;27:526.e7	NOUN
ecj-12310	157	5	-	-	SYM
ecj-12310	157	6	12	12	NUM
ecj-12310	157	7	.	.	PUNCT
ecj-12310	158	1	9	9	NUM
ecj-12310	158	2	.	.	X
ecj-12310	158	3	kumar	kumar	PROPN
ecj-12310	158	4	g	g	PROPN
ecj-12310	158	5	,	,	PUNCT
ecj-12310	158	6	kalita	kalita	PROPN
ecj-12310	158	7	j	j	PROPN
ecj-12310	158	8	,	,	PUNCT
ecj-12310	158	9	misra	misra	PROPN
ecj-12310	158	10	uk	uk	PROPN
ecj-12310	158	11	.	.	PROPN
ecj-12310	158	12	raised	raise	VERB
ecj-12310	158	13	intracranial	intracranial	ADJ
ecj-12310	158	14	pressure	pressure	NOUN
ecj-12310	158	15	in	in	ADP
ecj-12310	158	16	acute	acute	ADJ
ecj-12310	158	17	viral	viral	ADJ
ecj-12310	158	18	encephalitis	encephalitis	NOUN
ecj-12310	158	19	.	.	PUNCT
ecj-12310	159	1	clin	clin	PROPN
ecj-12310	159	2	neurol	neurol	PROPN
ecj-12310	159	3	neurosurg	neurosurg	PROPN
ecj-12310	159	4	2009;111:399406	2009;111:399406	NUM
ecj-12310	159	5	.	.	PUNCT
ecj-12310	160	1	10	10	NUM
ecj-12310	160	2	.	.	PUNCT
ecj-12310	161	1	walcott	walcott	PROPN
ecj-12310	161	2	bp	bp	PROPN
ecj-12310	161	3	,	,	PUNCT
ecj-12310	161	4	kahle	kahle	PROPN
ecj-12310	161	5	kt	kt	PROPN
ecj-12310	161	6	,	,	PUNCT
ecj-12310	161	7	simard	simard	PROPN
ecj-12310	161	8	jm	jm	PROPN
ecj-12310	161	9	.	.	PROPN
ecj-12310	161	10	novel	novel	ADJ
ecj-12310	161	11	treatment	treatment	NOUN
ecj-12310	161	12	targets	target	NOUN
ecj-12310	161	13	for	for	ADP
ecj-12310	161	14	cerebral	cerebral	ADJ
ecj-12310	161	15	edema	edema	NOUN
ecj-12310	161	16	.	.	PUNCT
ecj-12310	162	1	neurotherapeutics	neurotherapeutics	PROPN
ecj-12310	162	2	2012;9:65	2012;9:65	PROPN
ecj-12310	162	3	-	-	PUNCT
ecj-12310	162	4	72	72	NUM
ecj-12310	162	5	.	.	PUNCT
ecj-12310	162	6	11	11	NUM
ecj-12310	162	7	.	.	PUNCT
ecj-12310	163	1	huang	huang	PROPN
ecj-12310	163	2	x	x	PROPN
ecj-12310	163	3	,	,	PUNCT
ecj-12310	163	4	yang	yang	PROPN
ecj-12310	163	5	l	l	PROPN
ecj-12310	163	6	,	,	PUNCT
ecj-12310	163	7	ye	ye	PROPN
ecj-12310	163	8	j	j	PROPN
ecj-12310	163	9	,	,	PUNCT
ecj-12310	163	10	et	et	PROPN
ecj-12310	163	11	al	al	PROPN
ecj-12310	163	12	.	.	PUNCT
ecj-12310	163	13	equimolar	equimolar	PROPN
ecj-12310	163	14	doses	dose	NOUN
ecj-12310	163	15	of	of	ADP
ecj-12310	163	16	hypertonic	hypertonic	ADJ
ecj-12310	163	17	agents	agent	NOUN
ecj-12310	163	18	(	(	PUNCT
ecj-12310	163	19	saline	saline	NOUN
ecj-12310	163	20	or	or	CCONJ
ecj-12310	163	21	mannitol	mannitol	NOUN
ecj-12310	163	22	)	)	PUNCT
ecj-12310	163	23	in	in	ADP
ecj-12310	163	24	the	the	DET
ecj-12310	163	25	treatment	treatment	NOUN
ecj-12310	163	26	of	of	ADP
ecj-12310	163	27	intracranial	intracranial	ADJ
ecj-12310	163	28	hypertension	hypertension	NOUN
ecj-12310	163	29	after	after	ADP
ecj-12310	163	30	severe	severe	ADJ
ecj-12310	163	31	traumatic	traumatic	ADJ
ecj-12310	163	32	brain	brain	NOUN
ecj-12310	163	33	injury	injury	NOUN
ecj-12310	163	34	.	.	PUNCT
ecj-12310	164	1	medicine	medicine	NOUN
ecj-12310	164	2	(	(	PUNCT
ecj-12310	164	3	baltimore	baltimore	PROPN
ecj-12310	164	4	)	)	PUNCT
ecj-12310	164	5	2020;99	2020;99	NUM
ecj-12310	164	6	:	:	PUNCT
ecj-12310	164	7	e22004	e22004	NOUN
ecj-12310	164	8	.	.	PUNCT
ecj-12310	165	1	12	12	NUM
ecj-12310	165	2	.	.	PUNCT
ecj-12310	166	1	pudenz	pudenz	PROPN
ecj-12310	166	2	rh	rh	PROPN
ecj-12310	166	3	,	,	PUNCT
ecj-12310	166	4	todd	todd	PROPN
ecj-12310	166	5	em	em	PRON
ecj-12310	166	6	,	,	PUNCT
ecj-12310	166	7	shelden	shelden	PROPN
ecj-12310	166	8	ch	ch	PROPN
ecj-12310	166	9	.	.	PROPN
ecj-12310	166	10	head	head	PROPN
ecj-12310	166	11	injuries	injury	NOUN
ecj-12310	166	12	in	in	ADP
ecj-12310	166	13	infants	infant	NOUN
ecj-12310	166	14	and	and	CCONJ
ecj-12310	166	15	young	young	ADJ
ecj-12310	166	16	children	child	NOUN
ecj-12310	166	17	.	.	PUNCT
ecj-12310	167	1	calif	calif	PROPN
ecj-12310	167	2	med	med	PROPN
ecj-12310	167	3	1961;94:66–71	1961;94:66–71	PROPN
ecj-12310	167	4	.	.	PROPN
ecj-12310	168	1	13	13	NUM
ecj-12310	168	2	.	.	PUNCT
ecj-12310	168	3	applegate	applegate	PROPN
ecj-12310	168	4	rl	rl	PROPN
ecj-12310	168	5	,	,	PUNCT
ecj-12310	168	6	chen	chen	PROPN
ecj-12310	168	7	g	g	PROPN
ecj-12310	168	8	,	,	PUNCT
ecj-12310	168	9	feng	feng	PROPN
ecj-12310	168	10	h	h	PROPN
ecj-12310	168	11	,	,	PUNCT
ecj-12310	168	12	zhang	zhang	PROPN
ecj-12310	168	13	jh	jh	PROPN
ecj-12310	168	14	(	(	PUNCT
ecj-12310	168	15	eds	eds	PROPN
ecj-12310	168	16	.	.	PUNCT
ecj-12310	168	17	)	)	PUNCT
ecj-12310	168	18	.	.	PUNCT
ecj-12310	169	1	brain	brain	NOUN
ecj-12310	169	2	edema	edema	PROPN
ecj-12310	169	3	xvi	xvi	NOUN
ecj-12310	169	4	:	:	PUNCT
ecj-12310	169	5	translate	translate	VERB
ecj-12310	169	6	basic	basic	ADJ
ecj-12310	169	7	science	science	NOUN
ecj-12310	169	8	into	into	ADP
ecj-12310	169	9	clinical	clinical	ADJ
ecj-12310	169	10	practice	practice	NOUN
ecj-12310	169	11	.	.	PUNCT
ecj-12310	170	1	acta	acta	PROPN
ecj-12310	170	2	neurochirurgica	neurochirurgica	PROPN
ecj-12310	170	3	supplement	supplement	VERB
ecj-12310	170	4	2016;121	2016;121	NUM
ecj-12310	170	5	.	.	PUNCT
ecj-12310	171	1	14	14	NUM
ecj-12310	171	2	.	.	PUNCT
ecj-12310	172	1	ali	ali	PROPN
ecj-12310	172	2	a	a	PROPN
ecj-12310	172	3	,	,	PUNCT
ecj-12310	172	4	tetik	tetik	ADV
ecj-12310	172	5	a	a	PRON
ecj-12310	172	6	,	,	PUNCT
ecj-12310	172	7	sabanci	sabanci	PROPN
ecj-12310	172	8	pa	pa	PROPN
ecj-12310	172	9	,	,	PUNCT
ecj-12310	172	10	et	et	PROPN
ecj-12310	172	11	al	al	PROPN
ecj-12310	172	12	.	.	PROPN
ecj-12310	172	13	comparison	comparison	NOUN
ecj-12310	172	14	of	of	ADP
ecj-12310	172	15	3	3	NUM
ecj-12310	172	16	%	%	NOUN
ecj-12310	172	17	hypertonic	hypertonic	ADJ
ecj-12310	172	18	saline	saline	NOUN
ecj-12310	172	19	and	and	CCONJ
ecj-12310	172	20	20	20	NUM
ecj-12310	172	21	%	%	NOUN
ecj-12310	172	22	mannitol	mannitol	NOUN
ecj-12310	172	23	for	for	ADP
ecj-12310	172	24	reducing	reduce	VERB
ecj-12310	172	25	intracranial	intracranial	ADJ
ecj-12310	172	26	pressure	pressure	NOUN
ecj-12310	172	27	in	in	ADP
ecj-12310	172	28	patients	patient	NOUN
ecj-12310	172	29	undergoing	undergo	VERB
ecj-12310	172	30	supratentorial	supratentorial	ADJ
ecj-12310	172	31	brain	brain	NOUN
ecj-12310	172	32	tumor	tumor	NOUN
ecj-12310	172	33	surgery	surgery	NOUN
ecj-12310	172	34	:	:	PUNCT
ecj-12310	172	35	a	a	DET
ecj-12310	172	36	randomized	randomized	ADJ
ecj-12310	172	37	,	,	PUNCT
ecj-12310	172	38	double	double	ADJ
ecj-12310	172	39	-	-	PUNCT
ecj-12310	172	40	blind	blind	ADJ
ecj-12310	172	41	clinical	clinical	ADJ
ecj-12310	172	42	trial	trial	NOUN
ecj-12310	172	43	.	.	PUNCT
ecj-12310	173	1	j	j	PROPN
ecj-12310	173	2	neurosurg	neurosurg	PROPN
ecj-12310	173	3	anesthesiol	anesthesiol	PROPN
ecj-12310	173	4	2018;30:171	2018;30:171	NUM
ecj-12310	173	5	-	-	SYM
ecj-12310	173	6	8	8	NUM
ecj-12310	173	7	.	.	NOUN
ecj-12310	173	8	15	15	NUM
ecj-12310	173	9	.	.	PUNCT
ecj-12310	174	1	diringer	diringer	PROPN
ecj-12310	174	2	mn	mn	PROPN
ecj-12310	174	3	.	.	PUNCT
ecj-12310	175	1	the	the	DET
ecj-12310	175	2	evolution	evolution	NOUN
ecj-12310	175	3	of	of	ADP
ecj-12310	175	4	the	the	DET
ecj-12310	175	5	clinical	clinical	ADJ
ecj-12310	175	6	use	use	NOUN
ecj-12310	175	7	of	of	ADP
ecj-12310	175	8	osmotic	osmotic	ADJ
ecj-12310	175	9	therapy	therapy	NOUN
ecj-12310	175	10	in	in	ADP
ecj-12310	175	11	the	the	DET
ecj-12310	175	12	treatment	treatment	NOUN
ecj-12310	175	13	of	of	ADP
ecj-12310	175	14	cerebral	cerebral	ADJ
ecj-12310	175	15	edema	edema	NOUN
ecj-12310	175	16	.	.	PUNCT
ecj-12310	176	1	acta	acta	PROPN
ecj-12310	176	2	neurochir	neurochir	PROPN
ecj-12310	176	3	suppl	suppl	PROPN
ecj-12310	177	1	2016;121:3	2016;121:3	NUM
ecj-12310	177	2	-	-	SYM
ecj-12310	177	3	6	6	NUM
ecj-12310	177	4	.	.	NOUN
ecj-12310	177	5	16	16	NUM
ecj-12310	177	6	.	.	PUNCT
ecj-12310	177	7	shawkat	shawkat	PROPN
ecj-12310	177	8	h	h	PROPN
ecj-12310	177	9	,	,	PUNCT
ecj-12310	177	10	westwood	westwood	PROPN
ecj-12310	177	11	m	m	PROPN
ecj-12310	177	12	-	-	PROPN
ecj-12310	177	13	m	m	PROPN
ecj-12310	177	14	,	,	PUNCT
ecj-12310	177	15	mortimer	mortimer	PROPN
ecj-12310	177	16	a.	a.	NOUN
ecj-12310	177	17	mannitol	mannitol	PROPN
ecj-12310	177	18	:	:	PUNCT
ecj-12310	177	19	a	a	DET
ecj-12310	177	20	review	review	NOUN
ecj-12310	177	21	of	of	ADP
ecj-12310	177	22	its	its	PRON
ecj-12310	177	23	clinical	clinical	ADJ
ecj-12310	177	24	uses	use	NOUN
ecj-12310	177	25	.	.	PUNCT
ecj-12310	178	1	cont	cont	PROPN
ecj-12310	178	2	educ	educ	PROPN
ecj-12310	178	3	anaesth	anaesth	PROPN
ecj-12310	178	4	critical	critical	ADJ
ecj-12310	178	5	care	care	NOUN
ecj-12310	178	6	pain	pain	PROPN
ecj-12310	178	7	2012;12:82–5	2012;12:82–5	PROPN
ecj-12310	178	8	.	.	PUNCT
ecj-12310	178	9	17	17	NUM
ecj-12310	178	10	.	.	PUNCT
ecj-12310	179	1	boone	boone	PROPN
ecj-12310	179	2	md	md	PROPN
ecj-12310	179	3	,	,	PUNCT
ecj-12310	179	4	oren	oren	PROPN
ecj-12310	179	5	-	-	PUNCT
ecj-12310	179	6	grinberg	grinberg	PROPN
ecj-12310	179	7	a	a	PROPN
ecj-12310	179	8	,	,	PUNCT
ecj-12310	179	9	robinson	robinson	PROPN
ecj-12310	179	10	tm	tm	PROPN
ecj-12310	179	11	,	,	PUNCT
ecj-12310	179	12	et	et	PROPN
ecj-12310	179	13	al	al	PROPN
ecj-12310	179	14	.	.	PROPN
ecj-12310	179	15	mannitol	mannitol	NOUN
ecj-12310	179	16	or	or	CCONJ
ecj-12310	179	17	hypertonic	hypertonic	ADJ
ecj-12310	179	18	saline	saline	NOUN
ecj-12310	179	19	in	in	ADP
ecj-12310	179	20	the	the	DET
ecj-12310	179	21	setting	setting	NOUN
ecj-12310	179	22	of	of	ADP
ecj-12310	179	23	traumatic	traumatic	ADJ
ecj-12310	179	24	brain	brain	NOUN
ecj-12310	179	25	injury	injury	NOUN
ecj-12310	179	26	:	:	PUNCT
ecj-12310	179	27	what	what	PRON
ecj-12310	179	28	have	have	AUX
ecj-12310	179	29	we	we	PRON
ecj-12310	179	30	learned	learn	VERB
ecj-12310	179	31	?	?	PUNCT
ecj-12310	180	1	surg	surg	PROPN
ecj-12310	180	2	neurol	neurol	PROPN
ecj-12310	180	3	int	int	PROPN
ecj-12310	180	4	2015;6:177	2015;6:177	NUM
ecj-12310	180	5	.	.	PROPN
ecj-12310	180	6	18	18	NUM
ecj-12310	180	7	.	.	PUNCT
ecj-12310	181	1	roberts	roberts	PROPN
ecj-12310	181	2	i	i	PROPN
ecj-12310	181	3	,	,	PUNCT
ecj-12310	181	4	schierhout	schierhout	NOUN
ecj-12310	181	5	g	g	NOUN
ecj-12310	181	6	,	,	PUNCT
ecj-12310	181	7	wakai	wakai	ADJ
ecj-12310	181	8	a.	a.	NOUN
ecj-12310	181	9	mannitol	mannitol	NOUN
ecj-12310	181	10	for	for	ADP
ecj-12310	181	11	acute	acute	ADJ
ecj-12310	181	12	traumatic	traumatic	ADJ
ecj-12310	181	13	brain	brain	NOUN
ecj-12310	181	14	injury	injury	NOUN
ecj-12310	181	15	.	.	PUNCT
ecj-12310	182	1	cochrane	cochrane	NOUN
ecj-12310	182	2	database	database	PROPN
ecj-12310	182	3	syst	syst	PROPN
ecj-12310	182	4	rev	rev	VERB
ecj-12310	182	5	2003;2	2003;2	NUM
ecj-12310	182	6	:	:	PUNCT
ecj-12310	182	7	cd001049	cd001049	PROPN
ecj-12310	182	8	.	.	PROPN
ecj-12310	183	1	19	19	NUM
ecj-12310	183	2	.	.	PUNCT
ecj-12310	184	1	chen	chen	PROPN
ecj-12310	184	2	h	h	PROPN
ecj-12310	184	3	,	,	PUNCT
ecj-12310	184	4	song	song	PROPN
ecj-12310	184	5	z	z	PROPN
ecj-12310	184	6	,	,	PUNCT
ecj-12310	184	7	dennis	dennis	PROPN
ecj-12310	184	8	ja	ja	PROPN
ecj-12310	184	9	.	.	PUNCT
ecj-12310	184	10	hypertonic	hypertonic	ADJ
ecj-12310	184	11	saline	saline	NOUN
ecj-12310	184	12	versus	versus	ADP
ecj-12310	184	13	other	other	ADJ
ecj-12310	184	14	intracranial	intracranial	ADJ
ecj-12310	184	15	pressure	pressure	NOUN
ecj-12310	184	16	–	–	PUNCT
ecj-12310	184	17	lowering	lower	VERB
ecj-12310	184	18	agents	agent	NOUN
ecj-12310	184	19	for	for	ADP
ecj-12310	184	20	people	people	NOUN
ecj-12310	184	21	with	with	ADP
ecj-12310	184	22	acute	acute	ADJ
ecj-12310	184	23	traumatic	traumatic	ADJ
ecj-12310	184	24	brain	brain	NOUN
ecj-12310	184	25	injury	injury	NOUN
ecj-12310	184	26	.	.	PUNCT
ecj-12310	185	1	cochrane	cochrane	NOUN
ecj-12310	185	2	database	database	PROPN
ecj-12310	185	3	syst	syst	PROPN
ecj-12310	185	4	rev	rev	PROPN
ecj-12310	185	5	2020;1	2020;1	NUM
ecj-12310	185	6	:	:	PUNCT
ecj-12310	185	7	cd010904	cd010904	ADJ
ecj-12310	185	8	.	.	PUNCT
ecj-12310	186	1	20	20	NUM
ecj-12310	186	2	.	.	PUNCT
ecj-12310	187	1	surani	surani	PROPN
ecj-12310	187	2	s	s	PROPN
ecj-12310	187	3	,	,	PUNCT
ecj-12310	187	4	lockwood	lockwood	PROPN
ecj-12310	187	5	g	g	PROPN
ecj-12310	187	6	,	,	PUNCT
ecj-12310	187	7	macias	macias	PROPN
ecj-12310	187	8	my	my	PRON
ecj-12310	187	9	,	,	PUNCT
ecj-12310	187	10	et	et	PROPN
ecj-12310	187	11	al	al	PROPN
ecj-12310	187	12	.	.	PUNCT
ecj-12310	188	1	hypertonic	hypertonic	ADJ
ecj-12310	188	2	saline	saline	NOUN
ecj-12310	188	3	in	in	ADP
ecj-12310	188	4	elevated	elevate	VERB
ecj-12310	188	5	intracranial	intracranial	ADJ
ecj-12310	188	6	pressure	pressure	NOUN
ecj-12310	188	7	:	:	PUNCT
ecj-12310	188	8	past	past	ADJ
ecj-12310	188	9	,	,	PUNCT
ecj-12310	188	10	present	present	ADJ
ecj-12310	188	11	,	,	PUNCT
ecj-12310	188	12	and	and	CCONJ
ecj-12310	188	13	future	future	NOUN
ecj-12310	188	14	.	.	PUNCT
ecj-12310	189	1	j	j	PROPN
ecj-12310	189	2	intens	inten	NOUN
ecj-12310	189	3	care	care	VERB
ecj-12310	189	4	med	med	ADJ
ecj-12310	189	5	2015;30:8–12	2015;30:8–12	NUM
ecj-12310	189	6	.	.	PUNCT
ecj-12310	190	1	21	21	NUM
ecj-12310	190	2	.	.	PUNCT
ecj-12310	190	3	seppelt	seppelt	PROPN
ecj-12310	190	4	i.	i.	PROPN
ecj-12310	190	5	intracranial	intracranial	PROPN
ecj-12310	190	6	hypertension	hypertension	NOUN
ecj-12310	190	7	after	after	ADP
ecj-12310	190	8	traumatic	traumatic	ADJ
ecj-12310	190	9	brain	brain	NOUN
ecj-12310	190	10	injury	injury	NOUN
ecj-12310	190	11	.	.	PUNCT
ecj-12310	191	1	indian	indian	PROPN
ecj-12310	191	2	j	j	PROPN
ecj-12310	191	3	crit	crit	PROPN
ecj-12310	191	4	care	care	NOUN
ecj-12310	191	5	2004;8:120	2004;8:120	PROPN
ecj-12310	191	6	-	-	SYM
ecj-12310	191	7	6	6	NUM
ecj-12310	191	8	.	.	NOUN
ecj-12310	191	9	22	22	NUM
ecj-12310	191	10	.	.	PUNCT
ecj-12310	192	1	horn	horn	PROPN
ecj-12310	192	2	p	p	NOUN
ecj-12310	192	3	,	,	PUNCT
ecj-12310	192	4	münch	münch	NOUN
ecj-12310	192	5	e	e	NOUN
ecj-12310	192	6	,	,	PUNCT
ecj-12310	192	7	vajkoczy	vajkoczy	PROPN
ecj-12310	192	8	p	p	X
ecj-12310	192	9	,	,	PUNCT
ecj-12310	192	10	et	et	PROPN
ecj-12310	192	11	al	al	PROPN
ecj-12310	192	12	.	.	PUNCT
ecj-12310	193	1	hypertonic	hypertonic	ADJ
ecj-12310	193	2	saline	saline	ADJ
ecj-12310	193	3	solution	solution	NOUN
ecj-12310	193	4	for	for	ADP
ecj-12310	193	5	control	control	NOUN
ecj-12310	193	6	of	of	ADP
ecj-12310	193	7	elevated	elevated	ADJ
ecj-12310	193	8	intracranial	intracranial	ADJ
ecj-12310	193	9	pressure	pressure	NOUN
ecj-12310	193	10	in	in	ADP
ecj-12310	193	11	patients	patient	NOUN
ecj-12310	193	12	with	with	ADP
ecj-12310	193	13	exhausted	exhausted	ADJ
ecj-12310	193	14	response	response	NOUN
ecj-12310	193	15	to	to	ADP
ecj-12310	193	16	mannitol	mannitol	NOUN
ecj-12310	193	17	and	and	CCONJ
ecj-12310	193	18	barbiturates	barbiturate	NOUN
ecj-12310	193	19	.	.	PUNCT
ecj-12310	194	1	neurol	neurol	PROPN
ecj-12310	194	2	res	re	VERB
ecj-12310	194	3	1999;21:758–64	1999;21:758–64	PROPN
ecj-12310	194	4	.	.	PROPN
ecj-12310	195	1	23	23	NUM
ecj-12310	195	2	.	.	X
ecj-12310	196	1	susanto	susanto	PROPN
ecj-12310	196	2	m	m	PROPN
ecj-12310	196	3	,	,	PUNCT
ecj-12310	196	4	riantri	riantri	ADJ
ecj-12310	196	5	i.	i.	PROPN
ecj-12310	196	6	optimal	optimal	PROPN
ecj-12310	196	7	dose	dose	NOUN
ecj-12310	196	8	and	and	CCONJ
ecj-12310	196	9	concentration	concentration	NOUN
ecj-12310	196	10	of	of	ADP
ecj-12310	196	11	hypertonic	hypertonic	ADJ
ecj-12310	196	12	saline	saline	NOUN
ecj-12310	196	13	in	in	ADP
ecj-12310	196	14	traumatic	traumatic	ADJ
ecj-12310	196	15	brain	brain	NOUN
ecj-12310	196	16	injury	injury	NOUN
ecj-12310	196	17	:	:	PUNCT
ecj-12310	196	18	a	a	DET
ecj-12310	196	19	systematic	systematic	ADJ
ecj-12310	196	20	review	review	NOUN
ecj-12310	196	21	.	.	PUNCT
ecj-12310	197	1	medeni	medeni	PROPN
ecj-12310	197	2	med	med	PROPN
ecj-12310	197	3	j	j	PROPN
ecj-12310	197	4	2022;37:203	2022;37:203	NUM
ecj-12310	197	5	-	-	SYM
ecj-12310	197	6	11	11	NUM
ecj-12310	197	7	.	.	PUNCT
ecj-12310	197	8	24	24	NUM
ecj-12310	197	9	.	.	PUNCT
ecj-12310	198	1	brophy	brophy	PROPN
ecj-12310	198	2	gm	gm	PROPN
ecj-12310	198	3	,	,	PUNCT
ecj-12310	198	4	human	human	PROPN
ecj-12310	198	5	t	t	PROPN
ecj-12310	198	6	,	,	PUNCT
ecj-12310	198	7	shutter	shutter	NOUN
ecj-12310	198	8	l.	l.	PROPN
ecj-12310	198	9	emergency	emergency	PROPN
ecj-12310	198	10	neurological	neurological	ADJ
ecj-12310	198	11	life	life	NOUN
ecj-12310	198	12	support	support	NOUN
ecj-12310	198	13	:	:	PUNCT
ecj-12310	198	14	pharmacotherapy	pharmacotherapy	NOUN
ecj-12310	198	15	.	.	PUNCT
ecj-12310	199	1	neurocrit	neurocrit	NUM
ecj-12310	199	2	care	care	NOUN
ecj-12310	199	3	2015;23	2015;23	NUM
ecj-12310	199	4	:	:	PUNCT
ecj-12310	199	5	s48	s48	PROPN
ecj-12310	199	6	-	-	PUNCT
ecj-12310	199	7	68	68	NUM
ecj-12310	199	8	.	.	PUNCT
ecj-12310	199	9	25	25	NUM
ecj-12310	199	10	.	.	PUNCT
ecj-12310	200	1	czosnyka	czosnyka	AUX
ecj-12310	200	2	m	m	PROPN
ecj-12310	200	3	,	,	PUNCT
ecj-12310	200	4	smielewski	smielewski	PROPN
ecj-12310	200	5	p	p	NOUN
ecj-12310	200	6	,	,	PUNCT
ecj-12310	200	7	timofeev	timofeev	NOUN
ecj-12310	200	8	i	i	PRON
ecj-12310	200	9	,	,	PUNCT
ecj-12310	200	10	et	et	PROPN
ecj-12310	200	11	al	al	PROPN
ecj-12310	200	12	.	.	PUNCT
ecj-12310	200	13	intracranial	intracranial	ADJ
ecj-12310	200	14	pressure	pressure	NOUN
ecj-12310	200	15	:	:	PUNCT
ecj-12310	200	16	more	more	ADJ
ecj-12310	200	17	than	than	ADP
ecj-12310	200	18	a	a	DET
ecj-12310	200	19	number	number	NOUN
ecj-12310	200	20	.	.	PUNCT
ecj-12310	201	1	neurosurg	neurosurg	ADJ
ecj-12310	201	2	focus	focus	VERB
ecj-12310	201	3	2007;22	2007;22	NOUN
ecj-12310	201	4	:	:	PUNCT
ecj-12310	201	5	e10	e10	NUM
ecj-12310	201	6	.	.	PUNCT
ecj-12310	202	1	26	26	NUM
ecj-12310	202	2	.	.	PUNCT
ecj-12310	202	3	czosnyka	czosnyka	AUX
ecj-12310	202	4	m	m	PROPN
ecj-12310	202	5	,	,	PUNCT
ecj-12310	202	6	pickard	pickard	PROPN
ecj-12310	202	7	jd	jd	PROPN
ecj-12310	202	8	.	.	PUNCT
ecj-12310	203	1	monitoring	monitoring	NOUN
ecj-12310	203	2	and	and	CCONJ
ecj-12310	203	3	interpretation	interpretation	NOUN
ecj-12310	203	4	of	of	ADP
ecj-12310	203	5	intracranial	intracranial	ADJ
ecj-12310	203	6	pressure	pressure	NOUN
ecj-12310	203	7	.	.	PUNCT
ecj-12310	204	1	j	j	PROPN
ecj-12310	204	2	neurol	neurol	PROPN
ecj-12310	204	3	neurosurg	neurosurg	VERB
ecj-12310	204	4	psychiatr	psychiatr	ADJ
ecj-12310	204	5	2004;75:813	2004;75:813	NUM
ecj-12310	204	6	-	-	SYM
ecj-12310	204	7	21	21	NUM
ecj-12310	204	8	.	.	PUNCT
ecj-12310	205	1	27	27	NUM
ecj-12310	205	2	.	.	PUNCT
ecj-12310	206	1	brain	brain	NOUN
ecj-12310	206	2	trauma	trauma	PROPN
ecj-12310	206	3	foundation	foundation	PROPN
ecj-12310	206	4	;	;	PUNCT
ecj-12310	206	5	american	american	PROPN
ecj-12310	206	6	association	association	PROPN
ecj-12310	206	7	of	of	ADP
ecj-12310	206	8	neurological	neurological	ADJ
ecj-12310	206	9	surgeons	surgeon	NOUN
ecj-12310	206	10	;	;	PUNCT
ecj-12310	206	11	congress	congress	PROPN
ecj-12310	206	12	of	of	ADP
ecj-12310	206	13	neurological	neurological	ADJ
ecj-12310	206	14	surgeons	surgeon	NOUN
ecj-12310	206	15	.	.	PUNCT
ecj-12310	207	1	guidelines	guideline	NOUN
ecj-12310	207	2	for	for	ADP
ecj-12310	207	3	the	the	DET
ecj-12310	207	4	management	management	NOUN
ecj-12310	207	5	of	of	ADP
ecj-12310	207	6	severe	severe	ADJ
ecj-12310	207	7	traumatic	traumatic	ADJ
ecj-12310	207	8	brain	brain	NOUN
ecj-12310	207	9	injury	injury	NOUN
ecj-12310	207	10	.	.	PUNCT
ecj-12310	208	1	j	j	PROPN
ecj-12310	208	2	neurotrauma	neurotrauma	PROPN
ecj-12310	208	3	2007;24	2007;24	NUM
ecj-12310	208	4	:	:	PUNCT
ecj-12310	208	5	s1	s1	NOUN
ecj-12310	208	6	-	-	PUNCT
ecj-12310	208	7	106	106	NUM
ecj-12310	208	8	.	.	PUNCT
ecj-12310	209	1	28	28	NUM
ecj-12310	209	2	.	.	PUNCT
ecj-12310	210	1	pedersen	pedersen	PROPN
ecj-12310	210	2	sh	sh	PROPN
ecj-12310	210	3	,	,	PUNCT
ecj-12310	210	4	lilja	lilja	NOUN
ecj-12310	210	5	-	-	PUNCT
ecj-12310	210	6	cyron	cyron	VERB
ecj-12310	210	7	a	a	PRON
ecj-12310	210	8	,	,	PUNCT
ecj-12310	210	9	andresen	andresen	PROPN
ecj-12310	210	10	m	m	PROPN
ecj-12310	210	11	,	,	PUNCT
ecj-12310	210	12	juhler	juhler	PROPN
ecj-12310	210	13	m.	m.	NOUN
ecj-12310	210	14	the	the	DET
ecj-12310	210	15	relationship	relationship	NOUN
ecj-12310	210	16	between	between	ADP
ecj-12310	210	17	intracranial	intracranial	ADJ
ecj-12310	210	18	pressure	pressure	NOUN
ecj-12310	210	19	and	and	CCONJ
ecj-12310	210	20	age	age	NOUN
ecj-12310	210	21	-	-	PUNCT
ecj-12310	210	22	chasing	chase	VERB
ecj-12310	210	23	agerelated	agerelate	VERB
ecj-12310	210	24	reference	reference	NOUN
ecj-12310	210	25	values	value	NOUN
ecj-12310	210	26	.	.	PUNCT
ecj-12310	211	1	world	world	PROPN
ecj-12310	211	2	neurosurg	neurosurg	PROPN
ecj-12310	211	3	2018;110	2018;110	NUM
ecj-12310	211	4	:	:	PUNCT
ecj-12310	211	5	e119	e119	PROPN
ecj-12310	211	6	-	-	SYM
ecj-12310	211	7	23	23	NUM
ecj-12310	211	8	.	.	PUNCT
ecj-12310	211	9	29	29	NUM
ecj-12310	211	10	.	.	PUNCT
ecj-12310	212	1	andresen	andresen	PROPN
ecj-12310	212	2	m	m	PROPN
ecj-12310	212	3	,	,	PUNCT
ecj-12310	212	4	hadi	hadi	PROPN
ecj-12310	212	5	a	a	PROPN
ecj-12310	212	6	,	,	PUNCT
ecj-12310	212	7	petersen	petersen	PROPN
ecj-12310	212	8	lg	lg	PROPN
ecj-12310	212	9	,	,	PUNCT
ecj-12310	212	10	et	et	PROPN
ecj-12310	212	11	al	al	PROPN
ecj-12310	212	12	.	.	PROPN
ecj-12310	212	13	effect	effect	NOUN
ecj-12310	212	14	of	of	ADP
ecj-12310	212	15	postural	postural	ADJ
ecj-12310	212	16	changes	change	NOUN
ecj-12310	212	17	on	on	ADP
ecj-12310	212	18	icp	icp	PROPN
ecj-12310	212	19	in	in	ADP
ecj-12310	212	20	healthy	healthy	ADJ
ecj-12310	212	21	and	and	CCONJ
ecj-12310	212	22	ill	ill	ADJ
ecj-12310	212	23	subjects	subject	NOUN
ecj-12310	212	24	.	.	PUNCT
ecj-12310	213	1	acta	acta	PROPN
ecj-12310	213	2	neurochir	neurochir	PROPN
ecj-12310	213	3	2015;157:109–13	2015;157:109–13	PROPN
ecj-12310	213	4	.	.	PUNCT
ecj-12310	214	1	30	30	NUM
ecj-12310	214	2	.	.	PUNCT
ecj-12310	214	3	eide	eide	PROPN
ecj-12310	214	4	pk	pk	PROPN
ecj-12310	214	5	,	,	PUNCT
ecj-12310	214	6	sroka	sroka	NOUN
ecj-12310	214	7	m	m	PROPN
ecj-12310	214	8	,	,	PUNCT
ecj-12310	214	9	wozniak	wozniak	PROPN
ecj-12310	214	10	a	a	X
ecj-12310	214	11	,	,	PUNCT
ecj-12310	214	12	sæhle	sæhle	NOUN
ecj-12310	214	13	t.	t.	NOUN
ecj-12310	214	14	morphological	morphological	ADJ
ecj-12310	214	15	characterization	characterization	NOUN
ecj-12310	214	16	of	of	ADP
ecj-12310	214	17	cardiac	cardiac	ADJ
ecj-12310	214	18	induced	induce	VERB
ecj-12310	214	19	intracranial	intracranial	ADJ
ecj-12310	214	20	pressure	pressure	NOUN
ecj-12310	214	21	(	(	PUNCT
ecj-12310	214	22	icp	icp	NOUN
ecj-12310	214	23	)	)	PUNCT
ecj-12310	214	24	waves	wave	NOUN
ecj-12310	214	25	in	in	ADP
ecj-12310	214	26	patients	patient	NOUN
ecj-12310	214	27	with	with	ADP
ecj-12310	214	28	overdrainage	overdrainage	NOUN
ecj-12310	214	29	of	of	ADP
ecj-12310	214	30	cerebrospinal	cerebrospinal	ADJ
ecj-12310	214	31	fluid	fluid	NOUN
ecj-12310	214	32	and	and	CCONJ
ecj-12310	214	33	negative	negative	ADJ
ecj-12310	214	34	icp	icp	PROPN
ecj-12310	214	35	.	.	PUNCT
ecj-12310	215	1	med	med	PROPN
ecj-12310	215	2	eng	eng	PROPN
ecj-12310	215	3	phys	phy	NOUN
ecj-12310	215	4	2012;34:1066	2012;34:1066	NUM
ecj-12310	215	5	-	-	SYM
ecj-12310	215	6	70	70	NUM
ecj-12310	215	7	.	.	PUNCT
ecj-12310	215	8	31	31	NUM
ecj-12310	215	9	.	.	PUNCT
ecj-12310	216	1	rosner	rosner	PROPN
ecj-12310	216	2	mj	mj	PROPN
ecj-12310	216	3	,	,	PUNCT
ecj-12310	216	4	rosner	rosner	PROPN
ecj-12310	216	5	sd	sd	PROPN
ecj-12310	216	6	,	,	PUNCT
ecj-12310	216	7	johnson	johnson	PROPN
ecj-12310	216	8	ah	ah	INTJ
ecj-12310	216	9	.	.	PUNCT
ecj-12310	217	1	cerebral	cerebral	ADJ
ecj-12310	217	2	perfusion	perfusion	NOUN
ecj-12310	217	3	pressure	pressure	NOUN
ecj-12310	217	4	:	:	PUNCT
ecj-12310	217	5	management	management	NOUN
ecj-12310	217	6	protocol	protocol	NOUN
ecj-12310	217	7	and	and	CCONJ
ecj-12310	217	8	clinical	clinical	ADJ
ecj-12310	217	9	results	result	NOUN
ecj-12310	217	10	.	.	PUNCT
ecj-12310	218	1	j	j	PROPN
ecj-12310	218	2	neurosurg	neurosurg	PROPN
ecj-12310	218	3	1995;83:949	1995;83:949	PROPN
ecj-12310	218	4	-	-	SYM
ecj-12310	218	5	62	62	NUM
ecj-12310	218	6	.	.	PUNCT
ecj-12310	219	1	32	32	NUM
ecj-12310	219	2	.	.	PUNCT
ecj-12310	220	1	czosnyka	czosnyka	AUX
ecj-12310	220	2	m	m	PROPN
ecj-12310	220	3	,	,	PUNCT
ecj-12310	220	4	price	price	NOUN
ecj-12310	220	5	dj	dj	NOUN
ecj-12310	220	6	,	,	PUNCT
ecj-12310	220	7	williamson	williamson	NOUN
ecj-12310	220	8	m.	m.	NOUN
ecj-12310	220	9	monitoring	monitoring	NOUN
ecj-12310	220	10	of	of	ADP
ecj-12310	220	11	cerebrospinal	cerebrospinal	ADJ
ecj-12310	220	12	dynamics	dynamic	NOUN
ecj-12310	220	13	using	use	VERB
ecj-12310	220	14	continuous	continuous	ADJ
ecj-12310	220	15	analysis	analysis	NOUN
ecj-12310	220	16	of	of	ADP
ecj-12310	220	17	intracranial	intracranial	ADJ
ecj-12310	220	18	pressure	pressure	NOUN
ecj-12310	220	19	and	and	CCONJ
ecj-12310	220	20	cerebral	cerebral	ADJ
ecj-12310	220	21	perfusion	perfusion	NOUN
ecj-12310	220	22	pressure	pressure	NOUN
ecj-12310	220	23	in	in	ADP
ecj-12310	220	24	head	head	NOUN
ecj-12310	220	25	injury	injury	NOUN
ecj-12310	220	26	.	.	PUNCT
ecj-12310	221	1	acta	acta	PROPN
ecj-12310	221	2	neurochir	neurochir	PROPN
ecj-12310	221	3	1994;126:113–9	1994;126:113–9	NUM
ecj-12310	221	4	.	.	PUNCT
ecj-12310	222	1	33	33	NUM
ecj-12310	222	2	.	.	PUNCT
ecj-12310	223	1	czosnyka	czosnyka	AUX
ecj-12310	223	2	m	m	PROPN
ecj-12310	223	3	,	,	PUNCT
ecj-12310	223	4	guazzo	guazzo	PROPN
ecj-12310	223	5	e	e	PROPN
ecj-12310	223	6	,	,	PUNCT
ecj-12310	223	7	whitehouse	whitehouse	NOUN
ecj-12310	223	8	m	m	PROPN
ecj-12310	223	9	,	,	PUNCT
ecj-12310	223	10	et	et	PROPN
ecj-12310	223	11	al	al	PROPN
ecj-12310	223	12	.	.	PROPN
ecj-12310	223	13	significance	significance	NOUN
ecj-12310	223	14	of	of	ADP
ecj-12310	223	15	intracranial	intracranial	ADJ
ecj-12310	223	16	pressure	pressure	NOUN
ecj-12310	223	17	waveform	waveform	VERB
ecj-12310	223	18	analysis	analysis	NOUN
ecj-12310	223	19	after	after	ADP
ecj-12310	223	20	head	head	NOUN
ecj-12310	223	21	injury	injury	NOUN
ecj-12310	223	22	.	.	PUNCT
ecj-12310	224	1	acta	acta	PROPN
ecj-12310	224	2	neurochir	neurochir	PROPN
ecj-12310	225	1	1996;138:531–42	1996;138:531–42	PROPN
ecj-12310	225	2	.	.	PROPN
ecj-12310	226	1	34	34	NUM
ecj-12310	226	2	.	.	PUNCT
ecj-12310	227	1	zweifel	zweifel	PROPN
ecj-12310	227	2	c	c	X
ecj-12310	227	3	,	,	PUNCT
ecj-12310	227	4	lavinio	lavinio	PROPN
ecj-12310	227	5	a	a	PRON
ecj-12310	227	6	,	,	PUNCT
ecj-12310	227	7	steiner	steiner	PROPN
ecj-12310	227	8	la	la	PROPN
ecj-12310	227	9	,	,	PUNCT
ecj-12310	227	10	et	et	PROPN
ecj-12310	227	11	al	al	PROPN
ecj-12310	227	12	.	.	PUNCT
ecj-12310	227	13	continuous	continuous	ADJ
ecj-12310	227	14	monitoring	monitoring	NOUN
ecj-12310	227	15	of	of	ADP
ecj-12310	227	16	cerebrovascular	cerebrovascular	ADJ
ecj-12310	227	17	pressure	pressure	NOUN
ecj-12310	227	18	reactivity	reactivity	NOUN
ecj-12310	227	19	in	in	ADP
ecj-12310	227	20	patients	patient	NOUN
ecj-12310	227	21	with	with	ADP
ecj-12310	227	22	head	head	NOUN
ecj-12310	227	23	injury	injury	NOUN
ecj-12310	227	24	.	.	PUNCT
ecj-12310	228	1	neurosurg	neurosurg	ADJ
ecj-12310	228	2	focus	focus	PROPN
ecj-12310	228	3	2008;25	2008;25	NUM
ecj-12310	228	4	:	:	PUNCT
ecj-12310	228	5	e2	e2	PROPN
ecj-12310	228	6	.	.	PUNCT
ecj-12310	229	1	35	35	NUM
ecj-12310	229	2	.	.	PUNCT
ecj-12310	230	1	rajagopal	rajagopal	PROPN
ecj-12310	230	2	r	r	NOUN
ecj-12310	230	3	,	,	PUNCT
ecj-12310	230	4	swaminathan	swaminathan	ADV
ecj-12310	230	5	g	g	PROPN
ecj-12310	230	6	,	,	PUNCT
ecj-12310	230	7	nair	nair	PROPN
ecj-12310	230	8	s	s	PROPN
ecj-12310	230	9	,	,	PUNCT
ecj-12310	230	10	joseph	joseph	PROPN
ecj-12310	230	11	m.	m.	PROPN
ecj-12310	230	12	hyponatremia	hyponatremia	PROPN
ecj-12310	230	13	in	in	ADP
ecj-12310	230	14	traumatic	traumatic	ADJ
ecj-12310	230	15	brain	brain	NOUN
ecj-12310	230	16	injury	injury	NOUN
ecj-12310	230	17	:	:	PUNCT
ecj-12310	230	18	a	a	DET
ecj-12310	230	19	practical	practical	ADJ
ecj-12310	230	20	management	management	NOUN
ecj-12310	230	21	protocol	protocol	NOUN
ecj-12310	230	22	.	.	PUNCT
ecj-12310	231	1	world	world	PROPN
ecj-12310	231	2	neurosurg	neurosurg	PROPN
ecj-12310	231	3	2017;108:529	2017;108:529	NUM
ecj-12310	231	4	-	-	SYM
ecj-12310	231	5	33	33	NUM
ecj-12310	231	6	.	.	PUNCT
ecj-12310	231	7	36	36	NUM
ecj-12310	231	8	.	.	PUNCT
ecj-12310	232	1	chang	chang	PROPN
ecj-12310	232	2	ch	ch	PROPN
ecj-12310	232	3	,	,	PUNCT
ecj-12310	232	4	liao	liao	PROPN
ecj-12310	232	5	jj	jj	PROPN
ecj-12310	232	6	,	,	PUNCT
ecj-12310	232	7	chuang	chuang	PROPN
ecj-12310	232	8	ch	ch	PROPN
ecj-12310	232	9	,	,	PUNCT
ecj-12310	232	10	lee	lee	PROPN
ecj-12310	232	11	ct	ct	PROPN
ecj-12310	232	12	.	.	PUNCT
ecj-12310	233	1	recurrent	recurrent	PROPN
ecj-12310	233	2	hyponatremia	hyponatremia	PROPN
ecj-12310	233	3	after	after	ADP
ecj-12310	233	4	traumatic	traumatic	ADJ
ecj-12310	233	5	brain	brain	NOUN
ecj-12310	233	6	injury	injury	NOUN
ecj-12310	233	7	.	.	PUNCT
ecj-12310	234	1	am	be	AUX
ecj-12310	234	2	j	j	PROPN
ecj-12310	234	3	med	med	PROPN
ecj-12310	234	4	sci	sci	PROPN
ecj-12310	234	5	2008;335:390	2008;335:390	PROPN
ecj-12310	234	6	-	-	SYM
ecj-12310	234	7	3	3	NUM
ecj-12310	234	8	.	.	NOUN
ecj-12310	234	9	37	37	NUM
ecj-12310	234	10	.	.	PUNCT
ecj-12310	235	1	koenig	koenig	PROPN
ecj-12310	235	2	ma	ma	PROPN
ecj-12310	235	3	.	.	PROPN
ecj-12310	235	4	cerebral	cerebral	PROPN
ecj-12310	235	5	edema	edema	PROPN
ecj-12310	235	6	and	and	CCONJ
ecj-12310	235	7	elevated	elevated	ADJ
ecj-12310	235	8	intracranial	intracranial	ADJ
ecj-12310	235	9	pressure	pressure	NOUN
ecj-12310	235	10	.	.	PUNCT
ecj-12310	236	1	continuum	continuum	PROPN
ecj-12310	236	2	(	(	PUNCT
ecj-12310	236	3	minneap	minneap	PROPN
ecj-12310	236	4	minn	minn	PROPN
ecj-12310	236	5	)	)	PUNCT
ecj-12310	237	1	2018;24:1588	2018;24:1588	NUM
ecj-12310	237	2	-	-	SYM
ecj-12310	237	3	602	602	NUM
ecj-12310	237	4	.	.	PUNCT
ecj-12310	238	1	38	38	NUM
ecj-12310	238	2	.	.	PUNCT
ecj-12310	239	1	rossi	rossi	PROPN
ecj-12310	239	2	s	s	PROPN
ecj-12310	239	3	,	,	PUNCT
ecj-12310	239	4	picetti	picetti	NOUN
ecj-12310	239	5	e	e	NOUN
ecj-12310	239	6	,	,	PUNCT
ecj-12310	239	7	zoerle	zoerle	PROPN
ecj-12310	239	8	t	t	PROPN
ecj-12310	239	9	,	,	PUNCT
ecj-12310	239	10	et	et	PROPN
ecj-12310	239	11	al	al	PROPN
ecj-12310	239	12	.	.	PUNCT
ecj-12310	239	13	fluid	fluid	ADJ
ecj-12310	239	14	management	management	NOUN
ecj-12310	239	15	in	in	ADP
ecj-12310	239	16	acute	acute	ADJ
ecj-12310	239	17	brain	brain	NOUN
ecj-12310	239	18	injury	injury	NOUN
ecj-12310	239	19	.	.	PUNCT
ecj-12310	240	1	curr	curr	PROPN
ecj-12310	240	2	neurol	neurol	PROPN
ecj-12310	240	3	neurosci	neurosci	PROPN
ecj-12310	240	4	rep	rep	PROPN
ecj-12310	240	5	2018;18:74	2018;18:74	PROPN
ecj-12310	240	6	.	.	PROPN
ecj-12310	241	1	39	39	NUM
ecj-12310	241	2	.	.	PUNCT
ecj-12310	242	1	hochwald	hochwald	ADJ
ecj-12310	242	2	gm	gm	PROPN
ecj-12310	242	3	,	,	PUNCT
ecj-12310	242	4	wald	wald	X
ecj-12310	242	5	a	a	X
ecj-12310	242	6	,	,	PUNCT
ecj-12310	242	7	dimattio	dimattio	PROPN
ecj-12310	242	8	j	j	PROPN
ecj-12310	242	9	,	,	PUNCT
ecj-12310	242	10	malhan	malhan	ADP
ecj-12310	242	11	c	c	NOUN
ecj-12310	242	12	:	:	PUNCT
ecj-12310	242	13	the	the	DET
ecj-12310	242	14	effects	effect	NOUN
ecj-12310	242	15	of	of	ADP
ecj-12310	242	16	serum	serum	NOUN
ecj-12310	242	17	osmolarity	osmolarity	NOUN
ecj-12310	242	18	on	on	ADP
ecj-12310	242	19	cerebrospinal	cerebrospinal	ADJ
ecj-12310	242	20	fluid	fluid	NOUN
ecj-12310	242	21	volume	volume	NOUN
ecj-12310	242	22	flow	flow	NOUN
ecj-12310	242	23	.	.	PUNCT
ecj-12310	243	1	life	life	NOUN
ecj-12310	243	2	sci	sci	PROPN
ecj-12310	243	3	1974;15:1309	1974;15:1309	NUM
ecj-12310	243	4	-	-	SYM
ecj-12310	243	5	16	16	NUM
ecj-12310	243	6	.	.	PUNCT
ecj-12310	244	1	review	review	NOUN
ecj-12310	245	1	[	[	X
ecj-12310	245	2	page	page	NOUN
ecj-12310	245	3	35	35	NUM
ecj-12310	245	4	]	]	PUNCT
ecj-12310	246	1	[	[	X
ecj-12310	246	2	emergency	emergency	NOUN
ecj-12310	246	3	care	care	NOUN
ecj-12310	246	4	journal	journal	PROPN
ecj-12310	246	5	2024	2024	NUM
ecj-12310	246	6	;	;	PUNCT
ecj-12310	246	7	20:12310	20:12310	NUM
ecj-12310	246	8	]	]	X
ecj-12310	246	9	non	non	ADJ
ecj-12310	246	10	-co	-co	PROPN
ecj-12310	246	11	mmerc	mmerc	PROPN
ecj-12310	246	12	ial	ial	PROPN
ecj-12310	246	13	us	us	PROPN
ecj-12310	246	14	e	e	NOUN
ecj-12310	246	15	o	o	NOUN
ecj-12310	246	16	nly	nly	ADV
ecj-12310	246	17	40	40	NUM
ecj-12310	246	18	.	.	PUNCT
ecj-12310	247	1	ichai	ichai	PROPN
ecj-12310	247	2	c	c	PROPN
ecj-12310	247	3	,	,	PUNCT
ecj-12310	247	4	armando	armando	PROPN
ecj-12310	247	5	g	g	PROPN
ecj-12310	247	6	,	,	PUNCT
ecj-12310	247	7	orban	orban	PROPN
ecj-12310	247	8	j	j	PROPN
ecj-12310	247	9	-	-	PUNCT
ecj-12310	247	10	c	c	PROPN
ecj-12310	247	11	,	,	PUNCT
ecj-12310	247	12	et	et	PROPN
ecj-12310	247	13	al	al	PROPN
ecj-12310	247	14	.	.	PROPN
ecj-12310	247	15	sodium	sodium	PROPN
ecj-12310	247	16	lactate	lactate	NOUN
ecj-12310	247	17	versus	versus	ADP
ecj-12310	247	18	mannitol	mannitol	NOUN
ecj-12310	247	19	in	in	ADP
ecj-12310	247	20	the	the	DET
ecj-12310	247	21	treatment	treatment	NOUN
ecj-12310	247	22	of	of	ADP
ecj-12310	247	23	intracranial	intracranial	ADJ
ecj-12310	247	24	hypertensive	hypertensive	ADJ
ecj-12310	247	25	episodes	episode	NOUN
ecj-12310	247	26	in	in	ADP
ecj-12310	247	27	severe	severe	ADJ
ecj-12310	247	28	traumatic	traumatic	ADJ
ecj-12310	247	29	brain	brain	NOUN
ecj-12310	247	30	-	-	PUNCT
ecj-12310	247	31	injured	injure	VERB
ecj-12310	247	32	patients	patient	NOUN
ecj-12310	247	33	.	.	PUNCT
ecj-12310	248	1	intens	inten	NOUN
ecj-12310	248	2	care	care	VERB
ecj-12310	248	3	med	med	ADJ
ecj-12310	248	4	2009;35:471	2009;35:471	PROPN
ecj-12310	248	5	-	-	SYM
ecj-12310	248	6	79	79	NUM
ecj-12310	248	7	.	.	PUNCT
ecj-12310	249	1	41	41	NUM
ecj-12310	249	2	.	.	PUNCT
ecj-12310	250	1	khanna	khanna	PROPN
ecj-12310	250	2	s	s	PROPN
ecj-12310	250	3	,	,	PUNCT
ecj-12310	250	4	davis	davis	PROPN
ecj-12310	250	5	d	d	PROPN
ecj-12310	250	6	,	,	PUNCT
ecj-12310	250	7	peterson	peterson	PROPN
ecj-12310	250	8	b	b	PROPN
ecj-12310	250	9	,	,	PUNCT
ecj-12310	250	10	et	et	PROPN
ecj-12310	250	11	al	al	PROPN
ecj-12310	250	12	.	.	PUNCT
ecj-12310	250	13	use	use	NOUN
ecj-12310	250	14	of	of	ADP
ecj-12310	250	15	hypertonic	hypertonic	ADJ
ecj-12310	250	16	saline	saline	NOUN
ecj-12310	250	17	in	in	ADP
ecj-12310	250	18	the	the	DET
ecj-12310	250	19	treatment	treatment	NOUN
ecj-12310	250	20	of	of	ADP
ecj-12310	250	21	severe	severe	ADJ
ecj-12310	250	22	refractory	refractory	NOUN
ecj-12310	250	23	post	post	VERB
ecj-12310	250	24	traumatic	traumatic	ADJ
ecj-12310	250	25	intracranial	intracranial	ADJ
ecj-12310	250	26	hypertension	hypertension	NOUN
ecj-12310	250	27	in	in	ADP
ecj-12310	250	28	pediatric	pediatric	ADJ
ecj-12310	250	29	traumatic	traumatic	ADJ
ecj-12310	250	30	brain	brain	NOUN
ecj-12310	250	31	injury	injury	NOUN
ecj-12310	250	32	.	.	PUNCT
ecj-12310	251	1	crit	crit	PROPN
ecj-12310	251	2	care	care	PROPN
ecj-12310	251	3	med	med	PROPN
ecj-12310	251	4	2000;28:1144	2000;28:1144	NUM
ecj-12310	251	5	-	-	SYM
ecj-12310	251	6	51	51	NUM
ecj-12310	251	7	.	.	PUNCT
ecj-12310	252	1	42	42	NUM
ecj-12310	252	2	.	.	PUNCT
ecj-12310	253	1	juul	juul	NOUN
ecj-12310	253	2	n	n	CCONJ
ecj-12310	253	3	,	,	PUNCT
ecj-12310	253	4	morris	morris	PROPN
ecj-12310	253	5	gf	gf	PROPN
ecj-12310	253	6	,	,	PUNCT
ecj-12310	253	7	marshall	marshall	PROPN
ecj-12310	253	8	sb	sb	PROPN
ecj-12310	253	9	,	,	PUNCT
ecj-12310	253	10	marshall	marshall	PROPN
ecj-12310	253	11	lf	lf	PROPN
ecj-12310	253	12	.	.	PROPN
ecj-12310	253	13	intracranial	intracranial	ADJ
ecj-12310	253	14	hypertension	hypertension	NOUN
ecj-12310	253	15	and	and	CCONJ
ecj-12310	253	16	cerebral	cerebral	ADJ
ecj-12310	253	17	perfusion	perfusion	NOUN
ecj-12310	253	18	pressure	pressure	NOUN
ecj-12310	253	19	:	:	PUNCT
ecj-12310	253	20	influence	influence	NOUN
ecj-12310	253	21	on	on	ADP
ecj-12310	253	22	neurological	neurological	ADJ
ecj-12310	253	23	deterioration	deterioration	NOUN
ecj-12310	253	24	and	and	CCONJ
ecj-12310	253	25	outcome	outcome	NOUN
ecj-12310	253	26	in	in	ADP
ecj-12310	253	27	severe	severe	ADJ
ecj-12310	253	28	head	head	NOUN
ecj-12310	253	29	injury	injury	NOUN
ecj-12310	253	30	.	.	PUNCT
ecj-12310	254	1	the	the	DET
ecj-12310	254	2	executive	executive	PROPN
ecj-12310	254	3	committee	committee	NOUN
ecj-12310	254	4	of	of	ADP
ecj-12310	254	5	the	the	DET
ecj-12310	254	6	international	international	ADJ
ecj-12310	254	7	selfotel	selfotel	NOUN
ecj-12310	254	8	trial	trial	NOUN
ecj-12310	254	9	.	.	PUNCT
ecj-12310	255	1	j	j	PROPN
ecj-12310	255	2	neurosurg	neurosurg	PROPN
ecj-12310	255	3	2000;92:1	2000;92:1	PROPN
ecj-12310	255	4	-	-	SYM
ecj-12310	255	5	6	6	NUM
ecj-12310	255	6	.	.	NOUN
ecj-12310	255	7	43	43	NUM
ecj-12310	255	8	.	.	PUNCT
ecj-12310	256	1	rangel	rangel	PROPN
ecj-12310	256	2	-	-	PUNCT
ecj-12310	256	3	castillo	castillo	PROPN
ecj-12310	256	4	l	l	PROPN
ecj-12310	256	5	,	,	PUNCT
ecj-12310	256	6	gopinath	gopinath	PROPN
ecj-12310	256	7	s	s	PART
ecj-12310	256	8	,	,	PUNCT
ecj-12310	256	9	robertson	robertson	PROPN
ecj-12310	256	10	cs	cs	PROPN
ecj-12310	256	11	.	.	PROPN
ecj-12310	256	12	management	management	NOUN
ecj-12310	256	13	of	of	ADP
ecj-12310	256	14	intracranial	intracranial	ADJ
ecj-12310	256	15	hypertension	hypertension	NOUN
ecj-12310	256	16	.	.	PUNCT
ecj-12310	257	1	neurol	neurol	PROPN
ecj-12310	257	2	clin	clin	PROPN
ecj-12310	257	3	2008;26:521–41	2008;26:521–41	PROPN
ecj-12310	257	4	.	.	PROPN
ecj-12310	257	5	44	44	NUM
ecj-12310	257	6	.	.	PUNCT
ecj-12310	257	7	carney	carney	PROPN
ecj-12310	257	8	n	n	PROPN
ecj-12310	257	9	,	,	PUNCT
ecj-12310	257	10	totten	totten	PROPN
ecj-12310	257	11	am	be	AUX
ecj-12310	257	12	,	,	PUNCT
ecj-12310	257	13	o'reilly	o'reilly	ADV
ecj-12310	257	14	c	c	X
ecj-12310	257	15	,	,	PUNCT
ecj-12310	257	16	et	et	PROPN
ecj-12310	257	17	al	al	PROPN
ecj-12310	257	18	.	.	PUNCT
ecj-12310	258	1	guidelines	guideline	NOUN
ecj-12310	258	2	for	for	ADP
ecj-12310	258	3	the	the	DET
ecj-12310	258	4	management	management	NOUN
ecj-12310	258	5	of	of	ADP
ecj-12310	258	6	severe	severe	ADJ
ecj-12310	258	7	traumatic	traumatic	ADJ
ecj-12310	258	8	brain	brain	NOUN
ecj-12310	258	9	injury	injury	NOUN
ecj-12310	258	10	.	.	PUNCT
ecj-12310	259	1	neurosurgery	neurosurgery	NOUN
ecj-12310	259	2	2017;80:6–15	2017;80:6–15	NUM
ecj-12310	259	3	.	.	PROPN
ecj-12310	260	1	45	45	NUM
ecj-12310	260	2	.	.	PUNCT
ecj-12310	260	3	schwimmbeck	schwimmbeck	PROPN
ecj-12310	260	4	f	f	PROPN
ecj-12310	260	5	,	,	PUNCT
ecj-12310	260	6	voellger	voellger	NOUN
ecj-12310	260	7	b	b	PROPN
ecj-12310	260	8	,	,	PUNCT
ecj-12310	260	9	chappell	chappell	NOUN
ecj-12310	260	10	d	d	NOUN
ecj-12310	260	11	,	,	PUNCT
ecj-12310	260	12	eberhart	eberhart	PROPN
ecj-12310	260	13	l.	l.	PROPN
ecj-12310	260	14	hypertonic	hypertonic	ADJ
ecj-12310	260	15	saline	saline	NOUN
ecj-12310	260	16	vs.	vs.	ADP
ecj-12310	260	17	mannitol	mannitol	NOUN
ecj-12310	260	18	for	for	ADP
ecj-12310	260	19	traumatic	traumatic	ADJ
ecj-12310	260	20	brain	brain	NOUN
ecj-12310	260	21	injury	injury	NOUN
ecj-12310	260	22	:	:	PUNCT
ecj-12310	260	23	a	a	DET
ecj-12310	260	24	systematic	systematic	ADJ
ecj-12310	260	25	review	review	NOUN
ecj-12310	260	26	and	and	CCONJ
ecj-12310	260	27	meta	meta	NOUN
ecj-12310	260	28	-	-	PUNCT
ecj-12310	260	29	analysis	analysis	NOUN
ecj-12310	260	30	with	with	ADP
ecj-12310	260	31	trial	trial	NOUN
ecj-12310	260	32	sequential	sequential	ADJ
ecj-12310	260	33	analysis	analysis	NOUN
ecj-12310	260	34	.	.	PUNCT
ecj-12310	261	1	j	j	PROPN
ecj-12310	261	2	neurosurg	neurosurg	PROPN
ecj-12310	261	3	anesthesiol	anesthesiol	VERB
ecj-12310	261	4	2021;33:10–20	2021;33:10–20	NUM
ecj-12310	261	5	.	.	PUNCT
ecj-12310	262	1	46	46	NUM
ecj-12310	262	2	.	.	PUNCT
ecj-12310	263	1	vialet	vialet	NOUN
ecj-12310	263	2	r	r	NOUN
ecj-12310	263	3	,	,	PUNCT
ecj-12310	263	4	albanèse	albanèse	PROPN
ecj-12310	263	5	j	j	PROPN
ecj-12310	263	6	,	,	PUNCT
ecj-12310	263	7	thomachot	thomachot	PROPN
ecj-12310	263	8	l	l	NOUN
ecj-12310	263	9	,	,	PUNCT
ecj-12310	263	10	et	et	PROPN
ecj-12310	263	11	al	al	PROPN
ecj-12310	263	12	.	.	PROPN
ecj-12310	263	13	isovolume	isovolume	ADJ
ecj-12310	263	14	hypertonic	hypertonic	ADJ
ecj-12310	263	15	solutes	solute	NOUN
ecj-12310	263	16	(	(	PUNCT
ecj-12310	263	17	sodium	sodium	NOUN
ecj-12310	263	18	chloride	chloride	NOUN
ecj-12310	263	19	or	or	CCONJ
ecj-12310	263	20	mannitol	mannitol	NOUN
ecj-12310	263	21	)	)	PUNCT
ecj-12310	263	22	in	in	ADP
ecj-12310	263	23	the	the	DET
ecj-12310	263	24	treatment	treatment	NOUN
ecj-12310	263	25	of	of	ADP
ecj-12310	263	26	refractory	refractory	NOUN
ecj-12310	263	27	posttraumatic	posttraumatic	ADJ
ecj-12310	263	28	intracranial	intracranial	ADJ
ecj-12310	263	29	hypertension	hypertension	NOUN
ecj-12310	263	30	:	:	PUNCT
ecj-12310	263	31	2	2	NUM
ecj-12310	263	32	ml	ml	NOUN
ecj-12310	263	33	/	/	SYM
ecj-12310	263	34	kg	kg	PROPN
ecj-12310	263	35	75	75	NUM
ecj-12310	263	36	%	%	NOUN
ecj-12310	263	37	saline	saline	NOUN
ecj-12310	263	38	is	be	AUX
ecj-12310	263	39	more	more	ADV
ecj-12310	263	40	effective	effective	ADJ
ecj-12310	263	41	than	than	ADP
ecj-12310	263	42	2	2	NUM
ecj-12310	263	43	ml	ml	NOUN
ecj-12310	263	44	/	/	SYM
ecj-12310	263	45	kg	kg	PROPN
ecj-12310	263	46	20	20	NUM
ecj-12310	263	47	%	%	NOUN
ecj-12310	263	48	mannitol	mannitol	NOUN
ecj-12310	263	49	.	.	PUNCT
ecj-12310	264	1	critical	critical	ADJ
ecj-12310	264	2	care	care	NOUN
ecj-12310	264	3	med	me	VERB
ecj-12310	264	4	2003;31:1683–7	2003;31:1683–7	NOUN
ecj-12310	264	5	.	.	PUNCT
ecj-12310	265	1	47	47	NUM
ecj-12310	265	2	.	.	PUNCT
ecj-12310	266	1	treib	treib	PROPN
ecj-12310	266	2	j	j	NOUN
ecj-12310	266	3	,	,	PUNCT
ecj-12310	266	4	haass	haass	VERB
ecj-12310	266	5	a	a	DET
ecj-12310	266	6	,	,	PUNCT
ecj-12310	266	7	pindur	pindur	PROPN
ecj-12310	266	8	g.	g.	PROPN
ecj-12310	266	9	coagulation	coagulation	NOUN
ecj-12310	266	10	disorders	disorder	NOUN
ecj-12310	266	11	caused	cause	VERB
ecj-12310	266	12	by	by	ADP
ecj-12310	266	13	hydroxyethyl	hydroxyethyl	NOUN
ecj-12310	266	14	starch	starch	NOUN
ecj-12310	266	15	.	.	PUNCT
ecj-12310	267	1	thromb	thromb	PROPN
ecj-12310	267	2	haemost	haemost	VERB
ecj-12310	267	3	1997;78:0974–83	1997;78:0974–83	NUM
ecj-12310	267	4	.	.	PUNCT
ecj-12310	268	1	48	48	NUM
ecj-12310	268	2	.	.	PUNCT
ecj-12310	269	1	moon	moon	PROPN
ecj-12310	269	2	pf	pf	PROPN
ecj-12310	269	3	,	,	PUNCT
ecj-12310	269	4	kramer	kramer	PROPN
ecj-12310	269	5	gc	gc	PROPN
ecj-12310	269	6	.	.	PROPN
ecj-12310	269	7	hypertonic	hypertonic	ADJ
ecj-12310	269	8	saline	saline	NOUN
ecj-12310	269	9	-	-	PUNCT
ecj-12310	269	10	dextran	dextran	NOUN
ecj-12310	269	11	resuscitation	resuscitation	NOUN
ecj-12310	269	12	from	from	ADP
ecj-12310	269	13	hemorrhagic	hemorrhagic	NOUN
ecj-12310	269	14	shock	shock	NOUN
ecj-12310	269	15	induces	induce	VERB
ecj-12310	269	16	transient	transient	ADJ
ecj-12310	269	17	mixed	mixed	ADJ
ecj-12310	269	18	acidosis	acidosis	NOUN
ecj-12310	269	19	.	.	PUNCT
ecj-12310	270	1	crit	crit	PROPN
ecj-12310	270	2	care	care	NOUN
ecj-12310	270	3	med	med	PROPN
ecj-12310	270	4	1995;23:323–1	1995;23:323–1	NUM
ecj-12310	270	5	.	.	PROPN
ecj-12310	271	1	49	49	NUM
ecj-12310	271	2	.	.	PUNCT
ecj-12310	272	1	mangat	mangat	PROPN
ecj-12310	272	2	hs	hs	PROPN
ecj-12310	272	3	,	,	PUNCT
ecj-12310	272	4	chiu	chiu	PROPN
ecj-12310	272	5	yl	yl	NOUN
ecj-12310	272	6	,	,	PUNCT
ecj-12310	272	7	gerber	gerber	PROPN
ecj-12310	272	8	lm	lm	PROPN
ecj-12310	272	9	,	,	PUNCT
ecj-12310	272	10	et	et	PROPN
ecj-12310	272	11	al	al	PROPN
ecj-12310	272	12	.	.	PUNCT
ecj-12310	273	1	hypertonic	hypertonic	ADJ
ecj-12310	273	2	saline	saline	NOUN
ecj-12310	273	3	reduces	reduce	VERB
ecj-12310	273	4	cumulative	cumulative	ADJ
ecj-12310	273	5	and	and	CCONJ
ecj-12310	273	6	daily	daily	ADJ
ecj-12310	273	7	intracranial	intracranial	ADJ
ecj-12310	273	8	pressure	pressure	NOUN
ecj-12310	273	9	burdens	burden	NOUN
ecj-12310	273	10	after	after	ADP
ecj-12310	273	11	severe	severe	ADJ
ecj-12310	273	12	traumatic	traumatic	ADJ
ecj-12310	273	13	brain	brain	NOUN
ecj-12310	273	14	injury	injury	NOUN
ecj-12310	273	15	.	.	PUNCT
ecj-12310	274	1	j	j	PROPN
ecj-12310	274	2	neurosurg	neurosurg	PROPN
ecj-12310	274	3	2015;122:2021	2015;122:2021	NUM
ecj-12310	274	4	.	.	PUNCT
ecj-12310	275	1	50	50	NUM
ecj-12310	275	2	.	.	PUNCT
ecj-12310	276	1	riou	riou	PROPN
ecj-12310	276	2	b	b	PROPN
ecj-12310	276	3	,	,	PUNCT
ecj-12310	276	4	carli	carli	PROPN
ecj-12310	276	5	p.	p.	PROPN
ecj-12310	276	6	chlorure	chlorure	NOUN
ecj-12310	276	7	de	de	PROPN
ecj-12310	276	8	sodium	sodium	NOUN
ecj-12310	276	9	hypertonique	hypertonique	NOUN
ecj-12310	276	10	et	et	PROPN
ecj-12310	276	11	choc	choc	NOUN
ecj-12310	276	12	hémorragique	hémorragique	NOUN
ecj-12310	277	1	[	[	X
ecj-12310	277	2	hypertonic	hypertonic	ADJ
ecj-12310	277	3	sodium	sodium	NOUN
ecj-12310	277	4	chloride	chloride	NOUN
ecj-12310	277	5	and	and	CCONJ
ecj-12310	277	6	hemorrhagic	hemorrhagic	NOUN
ecj-12310	277	7	shock	shock	NOUN
ecj-12310	277	8	]	]	PUNCT
ecj-12310	277	9	.	.	PUNCT
ecj-12310	278	1	ann	ann	PROPN
ecj-12310	278	2	fr	fr	PROPN
ecj-12310	278	3	anesth	anesth	VERB
ecj-12310	278	4	reanim	reanim	NOUN
ecj-12310	278	5	1990;9:536	1990;9:536	PROPN
ecj-12310	278	6	-	-	SYM
ecj-12310	278	7	46	46	NUM
ecj-12310	278	8	.	.	PUNCT
ecj-12310	279	1	french	french	PROPN
ecj-12310	279	2	.	.	PUNCT
ecj-12310	280	1	51	51	NUM
ecj-12310	280	2	.	.	PUNCT
ecj-12310	280	3	walsh	walsh	PROPN
ecj-12310	280	4	jc	jc	PROPN
ecj-12310	280	5	,	,	PUNCT
ecj-12310	280	6	zhuang	zhuang	PROPN
ecj-12310	280	7	j	j	PROPN
ecj-12310	280	8	,	,	PUNCT
ecj-12310	280	9	shackford	shackford	PROPN
ecj-12310	280	10	sr	sr	PROPN
ecj-12310	280	11	.	.	PUNCT
ecj-12310	281	1	a	a	DET
ecj-12310	281	2	comparison	comparison	NOUN
ecj-12310	281	3	of	of	ADP
ecj-12310	281	4	hypertonic	hypertonic	NOUN
ecj-12310	281	5	to	to	ADP
ecj-12310	281	6	isotonic	isotonic	ADJ
ecj-12310	281	7	fluid	fluid	NOUN
ecj-12310	281	8	in	in	ADP
ecj-12310	281	9	the	the	DET
ecj-12310	281	10	resuscitation	resuscitation	NOUN
ecj-12310	281	11	of	of	ADP
ecj-12310	281	12	brain	brain	NOUN
ecj-12310	281	13	injury	injury	NOUN
ecj-12310	281	14	and	and	CCONJ
ecj-12310	281	15	hemorrhagic	hemorrhagic	NOUN
ecj-12310	281	16	shock	shock	NOUN
ecj-12310	281	17	.	.	PUNCT
ecj-12310	282	1	j	j	PROPN
ecj-12310	282	2	surg	surg	PROPN
ecj-12310	282	3	res	re	VERB
ecj-12310	282	4	1991;50:284	1991;50:284	PROPN
ecj-12310	282	5	-	-	SYM
ecj-12310	282	6	92	92	NUM
ecj-12310	282	7	.	.	PUNCT
ecj-12310	282	8	52	52	NUM
ecj-12310	282	9	.	.	PUNCT
ecj-12310	283	1	kempski	kempski	PROPN
ecj-12310	283	2	o	o	PROPN
ecj-12310	283	3	,	,	PUNCT
ecj-12310	283	4	obert	obert	ADJ
ecj-12310	283	5	c	c	PROPN
ecj-12310	283	6	,	,	PUNCT
ecj-12310	283	7	mainka	mainka	PROPN
ecj-12310	283	8	t	t	PROPN
ecj-12310	283	9	,	,	PUNCT
ecj-12310	283	10	et	et	PROPN
ecj-12310	283	11	al	al	PROPN
ecj-12310	283	12	.	.	PUNCT
ecj-12310	284	1	“	"	PUNCT
ecj-12310	284	2	small	small	ADJ
ecj-12310	284	3	volume	volume	NOUN
ecj-12310	284	4	resuscitation	resuscitation	NOUN
ecj-12310	284	5	”	"	PUNCT
ecj-12310	284	6	as	as	ADP
ecj-12310	284	7	treatment	treatment	NOUN
ecj-12310	284	8	of	of	ADP
ecj-12310	284	9	cerebral	cerebral	ADJ
ecj-12310	284	10	blood	blood	NOUN
ecj-12310	284	11	flow	flow	NOUN
ecj-12310	284	12	disturbances	disturbance	NOUN
ecj-12310	284	13	and	and	CCONJ
ecj-12310	284	14	increased	increase	VERB
ecj-12310	284	15	icp	icp	PROPN
ecj-12310	284	16	in	in	ADP
ecj-12310	284	17	trauma	trauma	NOUN
ecj-12310	284	18	and	and	CCONJ
ecj-12310	284	19	ischemia	ischemia	NOUN
ecj-12310	284	20	.	.	PUNCT
ecj-12310	285	1	in	in	ADP
ecj-12310	285	2	mechanisms	mechanism	NOUN
ecj-12310	285	3	of	of	ADP
ecj-12310	285	4	secondary	secondary	ADJ
ecj-12310	285	5	brain	brain	NOUN
ecj-12310	285	6	damage	damage	NOUN
ecj-12310	285	7	in	in	ADP
ecj-12310	285	8	cerebral	cerebral	ADJ
ecj-12310	285	9	ischemia	ischemia	NOUN
ecj-12310	285	10	and	and	CCONJ
ecj-12310	285	11	trauma	trauma	NOUN
ecj-12310	285	12	.	.	PUNCT
ecj-12310	286	1	new	new	PROPN
ecj-12310	286	2	york	york	PROPN
ecj-12310	286	3	,	,	PUNCT
ecj-12310	286	4	ny	ny	PROPN
ecj-12310	286	5	:	:	PUNCT
ecj-12310	286	6	springer	springer	NOUN
ecj-12310	286	7	;	;	PUNCT
ecj-12310	286	8	1996	1996	NUM
ecj-12310	286	9	.	.	PUNCT
ecj-12310	287	1	p.	p.	NOUN
ecj-12310	287	2	114–117	114–117	NUM
ecj-12310	287	3	.	.	PUNCT
ecj-12310	288	1	53	53	NUM
ecj-12310	288	2	.	.	PUNCT
ecj-12310	289	1	doyle	doyle	PROPN
ecj-12310	289	2	ja	ja	PROPN
ecj-12310	289	3	,	,	PUNCT
ecj-12310	289	4	davis	davis	PROPN
ecj-12310	289	5	dp	dp	PROPN
ecj-12310	289	6	,	,	PUNCT
ecj-12310	289	7	hoyt	hoyt	PROPN
ecj-12310	289	8	db	db	PROPN
ecj-12310	289	9	.	.	PUNCT
ecj-12310	290	1	the	the	DET
ecj-12310	290	2	use	use	NOUN
ecj-12310	290	3	of	of	ADP
ecj-12310	290	4	hypertonic	hypertonic	ADJ
ecj-12310	290	5	saline	saline	NOUN
ecj-12310	290	6	in	in	ADP
ecj-12310	290	7	the	the	DET
ecj-12310	290	8	treatment	treatment	NOUN
ecj-12310	290	9	of	of	ADP
ecj-12310	290	10	traumatic	traumatic	ADJ
ecj-12310	290	11	brain	brain	NOUN
ecj-12310	290	12	injury	injury	NOUN
ecj-12310	290	13	.	.	PUNCT
ecj-12310	291	1	j	j	PROPN
ecj-12310	291	2	trauma	trauma	PROPN
ecj-12310	291	3	2001;50:36783	2001;50:36783	NUM
ecj-12310	291	4	.	.	PROPN
ecj-12310	291	5	54	54	NUM
ecj-12310	291	6	.	.	PUNCT
ecj-12310	292	1	battison	battison	PROPN
ecj-12310	292	2	c	c	PROPN
ecj-12310	292	3	,	,	PUNCT
ecj-12310	292	4	andrews	andrews	PROPN
ecj-12310	292	5	pj	pj	PROPN
ecj-12310	292	6	,	,	PUNCT
ecj-12310	292	7	graham	graham	PROPN
ecj-12310	292	8	c	c	PROPN
ecj-12310	292	9	,	,	PUNCT
ecj-12310	292	10	petty	petty	ADJ
ecj-12310	292	11	t.	t.	PROPN
ecj-12310	292	12	randomized	randomize	VERB
ecj-12310	292	13	,	,	PUNCT
ecj-12310	292	14	controlled	control	VERB
ecj-12310	292	15	trial	trial	NOUN
ecj-12310	292	16	on	on	ADP
ecj-12310	292	17	the	the	DET
ecj-12310	292	18	effect	effect	NOUN
ecj-12310	292	19	of	of	ADP
ecj-12310	292	20	a	a	DET
ecj-12310	292	21	20	20	NUM
ecj-12310	292	22	%	%	NOUN
ecj-12310	292	23	mannitol	mannitol	NOUN
ecj-12310	292	24	solution	solution	NOUN
ecj-12310	292	25	and	and	CCONJ
ecj-12310	292	26	a	a	DET
ecj-12310	292	27	7.5	7.5	NUM
ecj-12310	292	28	%	%	NOUN
ecj-12310	292	29	saline/6	saline/6	NUM
ecj-12310	292	30	%	%	NOUN
ecj-12310	292	31	dextran	dextran	NOUN
ecj-12310	292	32	solution	solution	NOUN
ecj-12310	292	33	on	on	ADP
ecj-12310	292	34	increased	increase	VERB
ecj-12310	292	35	intracranial	intracranial	ADJ
ecj-12310	292	36	pressure	pressure	NOUN
ecj-12310	292	37	after	after	ADP
ecj-12310	292	38	brain	brain	NOUN
ecj-12310	292	39	injury	injury	NOUN
ecj-12310	292	40	.	.	PUNCT
ecj-12310	293	1	critical	critical	ADJ
ecj-12310	293	2	care	care	NOUN
ecj-12310	293	3	med	me	VERB
ecj-12310	293	4	2005;33:196202	2005;33:196202	NUM
ecj-12310	293	5	;	;	PUNCT
ecj-12310	293	6	discussion	discussion	NOUN
ecj-12310	293	7	57	57	NUM
ecj-12310	293	8	-	-	SYM
ecj-12310	293	9	8	8	NUM
ecj-12310	293	10	.	.	PUNCT
ecj-12310	294	1	55	55	NUM
ecj-12310	294	2	.	.	PUNCT
ecj-12310	295	1	torre	torre	PROPN
ecj-12310	295	2	-	-	PUNCT
ecj-12310	295	3	healy	healy	PROPN
ecj-12310	295	4	a	a	PROPN
ecj-12310	295	5	,	,	PUNCT
ecj-12310	295	6	marko	marko	PROPN
ecj-12310	295	7	n	n	CCONJ
ecj-12310	295	8	,	,	PUNCT
ecj-12310	295	9	weil	weil	PROPN
ecj-12310	295	10	r.	r.	PROPN
ecj-12310	295	11	hyperosmolar	hyperosmolar	PROPN
ecj-12310	295	12	therapy	therapy	NOUN
ecj-12310	295	13	for	for	ADP
ecj-12310	295	14	intracranial	intracranial	ADJ
ecj-12310	295	15	hypertension	hypertension	NOUN
ecj-12310	295	16	.	.	PUNCT
ecj-12310	296	1	neurocrit	neurocrit	PROPN
ecj-12310	296	2	care	care	NOUN
ecj-12310	296	3	2012;117:117	2012;117:117	NUM
ecj-12310	296	4	-	-	SYM
ecj-12310	296	5	30	30	NUM
ecj-12310	296	6	.	.	PUNCT
ecj-12310	297	1	56	56	NUM
ecj-12310	297	2	.	.	X
ecj-12310	297	3	de	de	X
ecj-12310	297	4	vivo	vivo	NOUN
ecj-12310	297	5	p	p	NOUN
ecj-12310	297	6	,	,	PUNCT
ecj-12310	297	7	del	del	X
ecj-12310	297	8	gaudio	gaudio	PROPN
ecj-12310	297	9	a	a	X
ecj-12310	297	10	,	,	PUNCT
ecj-12310	297	11	ciritella	ciritella	PROPN
ecj-12310	297	12	p	p	X
ecj-12310	297	13	,	,	PUNCT
ecj-12310	297	14	et	et	PROPN
ecj-12310	297	15	al	al	PROPN
ecj-12310	297	16	.	.	PUNCT
ecj-12310	297	17	hypertonic	hypertonic	ADJ
ecj-12310	297	18	saline	saline	NOUN
ecj-12310	297	19	solution	solution	NOUN
ecj-12310	297	20	:	:	PUNCT
ecj-12310	297	21	a	a	DET
ecj-12310	297	22	safe	safe	ADJ
ecj-12310	297	23	alternative	alternative	NOUN
ecj-12310	297	24	to	to	ADP
ecj-12310	297	25	mannitol	mannitol	NOUN
ecj-12310	297	26	18	18	NUM
ecj-12310	297	27	%	%	NOUN
ecj-12310	297	28	in	in	ADP
ecj-12310	297	29	neurosurgery	neurosurgery	NOUN
ecj-12310	297	30	.	.	PUNCT
ecj-12310	298	1	miner	miner	NOUN
ecj-12310	298	2	anesthesiol	anesthesiol	PROPN
ecj-12310	298	3	2001;67:603	2001;67:603	PROPN
ecj-12310	298	4	-	-	SYM
ecj-12310	298	5	11	11	NUM
ecj-12310	298	6	.	.	PUNCT
ecj-12310	298	7	57	57	NUM
ecj-12310	298	8	.	.	PUNCT
ecj-12310	299	1	rozet	rozet	PROPN
ecj-12310	299	2	i	i	PRON
ecj-12310	299	3	,	,	PUNCT
ecj-12310	299	4	tontisirin	tontisirin	NOUN
ecj-12310	299	5	n	n	CCONJ
ecj-12310	299	6	,	,	PUNCT
ecj-12310	299	7	muangman	muangman	NOUN
ecj-12310	299	8	s	s	PART
ecj-12310	299	9	,	,	PUNCT
ecj-12310	299	10	et	et	PROPN
ecj-12310	299	11	al	al	PROPN
ecj-12310	299	12	.	.	PROPN
ecj-12310	299	13	effect	effect	NOUN
ecj-12310	299	14	of	of	ADP
ecj-12310	299	15	equiosmolar	equiosmolar	ADJ
ecj-12310	299	16	solutions	solution	NOUN
ecj-12310	299	17	of	of	ADP
ecj-12310	299	18	mannitol	mannitol	NOUN
ecj-12310	299	19	versus	versus	ADP
ecj-12310	299	20	hypertonic	hypertonic	ADJ
ecj-12310	299	21	saline	saline	NOUN
ecj-12310	299	22	on	on	ADP
ecj-12310	299	23	intraoperative	intraoperative	ADJ
ecj-12310	299	24	brain	brain	NOUN
ecj-12310	299	25	relaxation	relaxation	NOUN
ecj-12310	299	26	and	and	CCONJ
ecj-12310	299	27	electrolyte	electrolyte	NOUN
ecj-12310	299	28	balance	balance	NOUN
ecj-12310	299	29	.	.	PUNCT
ecj-12310	300	1	anesthesiol	anesthesiol	PROPN
ecj-12310	300	2	2007;107:697	2007;107:697	NUM
ecj-12310	300	3	-	-	SYM
ecj-12310	300	4	704	704	NUM
ecj-12310	300	5	.	.	PUNCT
ecj-12310	301	1	58	58	NUM
ecj-12310	301	2	.	.	PUNCT
ecj-12310	302	1	vassar	vassar	PROPN
ecj-12310	302	2	mj	mj	PROPN
ecj-12310	302	3	,	,	PUNCT
ecj-12310	302	4	perry	perry	PROPN
ecj-12310	302	5	ca	ca	PROPN
ecj-12310	302	6	,	,	PUNCT
ecj-12310	302	7	holcroft	holcroft	PROPN
ecj-12310	302	8	jw	jw	PROPN
ecj-12310	302	9	.	.	PROPN
ecj-12310	302	10	prehospital	prehospital	PROPN
ecj-12310	302	11	resuscitation	resuscitation	NOUN
ecj-12310	302	12	of	of	ADP
ecj-12310	302	13	hypotensive	hypotensive	ADJ
ecj-12310	302	14	trauma	trauma	NOUN
ecj-12310	302	15	patients	patient	NOUN
ecj-12310	302	16	with	with	ADP
ecj-12310	302	17	7.5	7.5	NUM
ecj-12310	302	18	%	%	NOUN
ecj-12310	302	19	nacl	nacl	NOUN
ecj-12310	302	20	versus	versus	ADP
ecj-12310	302	21	7.5	7.5	NUM
ecj-12310	302	22	%	%	NOUN
ecj-12310	302	23	nacl	nacl	NOUN
ecj-12310	302	24	with	with	ADP
ecj-12310	302	25	added	add	VERB
ecj-12310	302	26	dextran	dextran	NOUN
ecj-12310	302	27	:	:	PUNCT
ecj-12310	302	28	a	a	DET
ecj-12310	302	29	controlled	control	VERB
ecj-12310	302	30	trial	trial	NOUN
ecj-12310	302	31	.	.	PUNCT
ecj-12310	303	1	j	j	PROPN
ecj-12310	303	2	trauma	trauma	NOUN
ecj-12310	303	3	1993;34:622	1993;34:622	NUM
ecj-12310	303	4	-	-	SYM
ecj-12310	303	5	32	32	NUM
ecj-12310	303	6	.	.	PUNCT
ecj-12310	304	1	59	59	NUM
ecj-12310	304	2	.	.	PUNCT
ecj-12310	305	1	kamel	kamel	PROPN
ecj-12310	305	2	h	h	PROPN
ecj-12310	305	3	,	,	PUNCT
ecj-12310	305	4	navi	navi	PROPN
ecj-12310	305	5	bb	bb	PROPN
ecj-12310	305	6	,	,	PUNCT
ecj-12310	305	7	nakagawa	nakagawa	PROPN
ecj-12310	305	8	k	k	PROPN
ecj-12310	305	9	,	,	PUNCT
ecj-12310	305	10	et	et	PROPN
ecj-12310	305	11	al	al	PROPN
ecj-12310	305	12	.	.	PUNCT
ecj-12310	306	1	hypertonic	hypertonic	ADJ
ecj-12310	306	2	saline	saline	NOUN
ecj-12310	306	3	versus	versus	ADP
ecj-12310	306	4	mannitol	mannitol	NOUN
ecj-12310	306	5	for	for	ADP
ecj-12310	306	6	the	the	DET
ecj-12310	306	7	treatment	treatment	NOUN
ecj-12310	306	8	of	of	ADP
ecj-12310	306	9	elevated	elevated	ADJ
ecj-12310	306	10	intracranial	intracranial	ADJ
ecj-12310	306	11	pressure	pressure	NOUN
ecj-12310	306	12	:	:	PUNCT
ecj-12310	306	13	a	a	DET
ecj-12310	306	14	meta	meta	ADJ
ecj-12310	306	15	-	-	PUNCT
ecj-12310	306	16	analysis	analysis	NOUN
ecj-12310	306	17	of	of	ADP
ecj-12310	306	18	randomized	randomized	ADJ
ecj-12310	306	19	clinical	clinical	ADJ
ecj-12310	306	20	trials	trial	NOUN
ecj-12310	306	21	.	.	PUNCT
ecj-12310	307	1	crit	crit	PROPN
ecj-12310	307	2	care	care	PROPN
ecj-12310	307	3	med	me	VERB
ecj-12310	307	4	2011;39:554	2011;39:554	PROPN
ecj-12310	307	5	-	-	PROPN
ecj-12310	307	6	9	9	NUM
ecj-12310	307	7	.	.	NOUN
ecj-12310	307	8	60	60	NUM
ecj-12310	307	9	.	.	PUNCT
ecj-12310	308	1	bulger	bulger	PROPN
ecj-12310	308	2	em	em	PRON
ecj-12310	308	3	,	,	PUNCT
ecj-12310	308	4	cuschieri	cuschieri	PROPN
ecj-12310	308	5	j	j	PROPN
ecj-12310	308	6	,	,	PUNCT
ecj-12310	308	7	warner	warner	PROPN
ecj-12310	308	8	k	k	PROPN
ecj-12310	308	9	,	,	PUNCT
ecj-12310	309	1	maier	maier	PROPN
ecj-12310	309	2	rv	rv	PROPN
ecj-12310	309	3	.	.	PUNCT
ecj-12310	309	4	hypertonic	hypertonic	ADJ
ecj-12310	309	5	resuscitation	resuscitation	NOUN
ecj-12310	309	6	modulates	modulate	VERB
ecj-12310	309	7	the	the	DET
ecj-12310	309	8	inflammatory	inflammatory	ADJ
ecj-12310	309	9	response	response	NOUN
ecj-12310	309	10	in	in	ADP
ecj-12310	309	11	patients	patient	NOUN
ecj-12310	309	12	with	with	ADP
ecj-12310	309	13	traumatic	traumatic	ADJ
ecj-12310	309	14	hemorrhagic	hemorrhagic	NOUN
ecj-12310	309	15	shock	shock	NOUN
ecj-12310	309	16	.	.	PUNCT
ecj-12310	310	1	ann	ann	PROPN
ecj-12310	310	2	surg	surg	PROPN
ecj-12310	310	3	2007;245:63541	2007;245:63541	NUM
ecj-12310	310	4	.	.	PUNCT
ecj-12310	311	1	61	61	NUM
ecj-12310	311	2	.	.	PUNCT
ecj-12310	312	1	baker	baker	PROPN
ecj-12310	312	2	aj	aj	PROPN
ecj-12310	312	3	,	,	PUNCT
ecj-12310	312	4	rhind	rhind	NOUN
ecj-12310	312	5	sg	sg	PROPN
ecj-12310	312	6	,	,	PUNCT
ecj-12310	312	7	morrison	morrison	PROPN
ecj-12310	312	8	lj	lj	PROPN
ecj-12310	312	9	,	,	PUNCT
ecj-12310	312	10	et	et	PROPN
ecj-12310	312	11	al	al	PROPN
ecj-12310	312	12	.	.	PROPN
ecj-12310	312	13	resuscitation	resuscitation	PROPN
ecj-12310	312	14	with	with	ADP
ecj-12310	312	15	hypertonic	hypertonic	ADJ
ecj-12310	312	16	saline	saline	NOUN
ecj-12310	312	17	-	-	PUNCT
ecj-12310	312	18	dextran	dextran	NOUN
ecj-12310	312	19	reduces	reduce	VERB
ecj-12310	312	20	serum	serum	NOUN
ecj-12310	312	21	biomarker	biomarker	NOUN
ecj-12310	312	22	levels	level	NOUN
ecj-12310	312	23	and	and	CCONJ
ecj-12310	312	24	correlates	correlate	VERB
ecj-12310	312	25	with	with	ADP
ecj-12310	312	26	outcome	outcome	NOUN
ecj-12310	312	27	in	in	ADP
ecj-12310	312	28	severe	severe	ADJ
ecj-12310	312	29	traumatic	traumatic	ADJ
ecj-12310	312	30	brain	brain	NOUN
ecj-12310	312	31	injury	injury	NOUN
ecj-12310	312	32	patients	patient	NOUN
ecj-12310	312	33	.	.	PUNCT
ecj-12310	313	1	j	j	PROPN
ecj-12310	313	2	neurotrauma	neurotrauma	PROPN
ecj-12310	313	3	2009;26:1227	2009;26:1227	PROPN
ecj-12310	313	4	-	-	SYM
ecj-12310	313	5	40	40	NUM
ecj-12310	313	6	.	.	PUNCT
ecj-12310	314	1	62	62	NUM
ecj-12310	314	2	.	.	PUNCT
ecj-12310	315	1	bulger	bulger	PROPN
ecj-12310	315	2	em	em	PRON
ecj-12310	315	3	,	,	PUNCT
ecj-12310	315	4	may	may	PROPN
ecj-12310	315	5	s	s	PART
ecj-12310	315	6	,	,	PUNCT
ecj-12310	315	7	brasel	brasel	ADJ
ecj-12310	315	8	kj	kj	PROPN
ecj-12310	315	9	,	,	PUNCT
ecj-12310	315	10	et	et	PROPN
ecj-12310	315	11	al	al	PROPN
ecj-12310	315	12	.	.	PROPN
ecj-12310	316	1	out	out	ADP
ecj-12310	316	2	-	-	PUNCT
ecj-12310	316	3	of	of	ADP
ecj-12310	316	4	-	-	PUNCT
ecj-12310	316	5	hospital	hospital	NOUN
ecj-12310	316	6	hypertonic	hypertonic	ADJ
ecj-12310	316	7	resuscitation	resuscitation	NOUN
ecj-12310	316	8	following	follow	VERB
ecj-12310	316	9	severe	severe	ADJ
ecj-12310	316	10	traumatic	traumatic	ADJ
ecj-12310	316	11	brain	brain	NOUN
ecj-12310	316	12	injury	injury	NOUN
ecj-12310	316	13	:	:	PUNCT
ecj-12310	316	14	a	a	DET
ecj-12310	316	15	randomized	randomized	ADJ
ecj-12310	316	16	controlled	control	VERB
ecj-12310	316	17	trial	trial	NOUN
ecj-12310	316	18	.	.	PUNCT
ecj-12310	317	1	jama	jama	PROPN
ecj-12310	317	2	2010;30:1455	2010;30:1455	NUM
ecj-12310	317	3	-	-	SYM
ecj-12310	317	4	64	64	NUM
ecj-12310	317	5	.	.	PUNCT
ecj-12310	318	1	63	63	NUM
ecj-12310	318	2	.	.	PUNCT
ecj-12310	319	1	gupta	gupta	PROPN
ecj-12310	319	2	n	n	CCONJ
ecj-12310	319	3	,	,	PUNCT
ecj-12310	319	4	pandia	pandia	PROPN
ecj-12310	319	5	mp	mp	PROPN
ecj-12310	319	6	,	,	PUNCT
ecj-12310	319	7	desh	desh	PROPN
ecj-12310	319	8	hh	hh	PROPN
ecj-12310	319	9	.	.	PUNCT
ecj-12310	319	10	research	research	NOUN
ecj-12310	319	11	studies	study	NOUN
ecj-12310	319	12	that	that	PRON
ecj-12310	319	13	have	have	AUX
ecj-12310	319	14	influenced	influence	VERB
ecj-12310	319	15	practice	practice	NOUN
ecj-12310	319	16	of	of	ADP
ecj-12310	319	17	neuroanesthesiology	neuroanesthesiology	NOUN
ecj-12310	319	18	in	in	ADP
ecj-12310	319	19	recent	recent	ADJ
ecj-12310	319	20	years	year	NOUN
ecj-12310	319	21	:	:	PUNCT
ecj-12310	319	22	a	a	DET
ecj-12310	319	23	literature	literature	NOUN
ecj-12310	319	24	review	review	NOUN
ecj-12310	319	25	.	.	PUNCT
ecj-12310	320	1	indian	indian	PROPN
ecj-12310	320	2	j	j	PROPN
ecj-12310	320	3	anaesth	anaesth	PROPN
ecj-12310	320	4	2013;57:117	2013;57:117	PROPN
ecj-12310	320	5	-	-	SYM
ecj-12310	320	6	26	26	NUM
ecj-12310	320	7	.	.	PUNCT
ecj-12310	320	8	64	64	NUM
ecj-12310	320	9	.	.	PUNCT
ecj-12310	320	10	battison	battison	PROPN
ecj-12310	320	11	c	c	PROPN
ecj-12310	320	12	,	,	PUNCT
ecj-12310	320	13	andrews	andrews	PROPN
ecj-12310	320	14	pj	pj	PROPN
ecj-12310	320	15	,	,	PUNCT
ecj-12310	320	16	graham	graham	PROPN
ecj-12310	320	17	c	c	PROPN
ecj-12310	320	18	,	,	PUNCT
ecj-12310	320	19	petty	petty	ADJ
ecj-12310	320	20	t.	t.	PROPN
ecj-12310	320	21	randomized	randomize	VERB
ecj-12310	320	22	,	,	PUNCT
ecj-12310	320	23	controlled	control	VERB
ecj-12310	320	24	trial	trial	NOUN
ecj-12310	320	25	on	on	ADP
ecj-12310	320	26	the	the	DET
ecj-12310	320	27	effect	effect	NOUN
ecj-12310	320	28	of	of	ADP
ecj-12310	320	29	a	a	DET
ecj-12310	320	30	20	20	NUM
ecj-12310	320	31	%	%	NOUN
ecj-12310	320	32	mannitol	mannitol	NOUN
ecj-12310	320	33	solution	solution	NOUN
ecj-12310	320	34	and	and	CCONJ
ecj-12310	320	35	a	a	DET
ecj-12310	320	36	7.5	7.5	NUM
ecj-12310	320	37	%	%	NOUN
ecj-12310	320	38	saline/6	saline/6	NUM
ecj-12310	320	39	%	%	NOUN
ecj-12310	320	40	dextran	dextran	NOUN
ecj-12310	320	41	solution	solution	NOUN
ecj-12310	320	42	on	on	ADP
ecj-12310	320	43	increased	increase	VERB
ecj-12310	320	44	intracranial	intracranial	ADJ
ecj-12310	320	45	pressure	pressure	NOUN
ecj-12310	320	46	after	after	ADP
ecj-12310	320	47	brain	brain	NOUN
ecj-12310	320	48	injury	injury	NOUN
ecj-12310	320	49	.	.	PUNCT
ecj-12310	321	1	crit	crit	PROPN
ecj-12310	321	2	care	care	PROPN
ecj-12310	321	3	med	med	ADJ
ecj-12310	321	4	2005;33:196	2005;33:196	NUM
ecj-12310	321	5	-	-	SYM
ecj-12310	321	6	20	20	NUM
ecj-12310	321	7	.	.	PUNCT
ecj-12310	322	1	65	65	NUM
ecj-12310	322	2	.	.	PUNCT
ecj-12310	322	3	valadka	valadka	PROPN
ecj-12310	322	4	ab	ab	PROPN
ecj-12310	322	5	,	,	PUNCT
ecj-12310	322	6	gopinath	gopinath	PROPN
ecj-12310	322	7	sp	sp	PROPN
ecj-12310	322	8	,	,	PUNCT
ecj-12310	322	9	contant	contant	PROPN
ecj-12310	322	10	cf	cf	NOUN
ecj-12310	322	11	,	,	PUNCT
ecj-12310	322	12	et	et	PROPN
ecj-12310	322	13	al	al	PROPN
ecj-12310	322	14	.	.	PROPN
ecj-12310	322	15	relationship	relationship	NOUN
ecj-12310	322	16	of	of	ADP
ecj-12310	322	17	brain	brain	NOUN
ecj-12310	322	18	tissue	tissue	NOUN
ecj-12310	322	19	po2	po2	NOUN
ecj-12310	322	20	to	to	PART
ecj-12310	322	21	outcome	outcome	VERB
ecj-12310	322	22	after	after	ADP
ecj-12310	322	23	severe	severe	ADJ
ecj-12310	322	24	tbi	tbi	PROPN
ecj-12310	322	25	.	.	PUNCT
ecj-12310	323	1	crit	crit	PROPN
ecj-12310	323	2	care	care	PROPN
ecj-12310	323	3	med	me	VERB
ecj-12310	323	4	1998;26:1576	1998;26:1576	NUM
ecj-12310	323	5	-	-	SYM
ecj-12310	323	6	8	8	NUM
ecj-12310	323	7	.	.	PUNCT
ecj-12310	324	1	66	66	NUM
ecj-12310	324	2	.	.	PUNCT
ecj-12310	325	1	van	van	PROPN
ecj-12310	325	2	den	den	PROPN
ecj-12310	325	3	brink	brink	PROPN
ecj-12310	325	4	wa	wa	PROPN
ecj-12310	325	5	,	,	PUNCT
ecj-12310	325	6	van	van	PROPN
ecj-12310	325	7	santbrink	santbrink	NOUN
ecj-12310	325	8	h	h	PROPN
ecj-12310	325	9	,	,	PUNCT
ecj-12310	325	10	steyerberg	steyerberg	PROPN
ecj-12310	325	11	ew	ew	PROPN
ecj-12310	325	12	,	,	PUNCT
ecj-12310	325	13	et	et	PROPN
ecj-12310	325	14	al	al	PROPN
ecj-12310	325	15	.	.	PROPN
ecj-12310	325	16	brain	brain	NOUN
ecj-12310	325	17	oxygen	oxygen	NOUN
ecj-12310	325	18	tension	tension	NOUN
ecj-12310	325	19	in	in	ADP
ecj-12310	325	20	severe	severe	ADJ
ecj-12310	325	21	tbi	tbi	PROPN
ecj-12310	325	22	.	.	PUNCT
ecj-12310	326	1	neurosurgery	neurosurgery	PROPN
ecj-12310	326	2	2000;46:868	2000;46:868	PROPN
ecj-12310	326	3	-	-	SYM
ecj-12310	326	4	76	76	NUM
ecj-12310	326	5	.	.	PUNCT
ecj-12310	326	6	67	67	NUM
ecj-12310	326	7	.	.	PUNCT
ecj-12310	327	1	stiefel	stiefel	PROPN
ecj-12310	327	2	mf	mf	PROPN
ecj-12310	327	3	,	,	PUNCT
ecj-12310	327	4	spiotta	spiotta	VERB
ecj-12310	327	5	a	a	DET
ecj-12310	327	6	,	,	PUNCT
ecj-12310	327	7	gracias	gracias	PROPN
ecj-12310	327	8	vh	vh	PROPN
ecj-12310	327	9	,	,	PUNCT
ecj-12310	327	10	et	et	PROPN
ecj-12310	327	11	al	al	PROPN
ecj-12310	327	12	.	.	PROPN
ecj-12310	328	1	reduced	reduce	VERB
ecj-12310	328	2	mortality	mortality	NOUN
ecj-12310	328	3	rate	rate	NOUN
ecj-12310	328	4	in	in	ADP
ecj-12310	328	5	patients	patient	NOUN
ecj-12310	328	6	with	with	ADP
ecj-12310	328	7	severe	severe	ADJ
ecj-12310	328	8	traumatic	traumatic	ADJ
ecj-12310	328	9	brain	brain	NOUN
ecj-12310	328	10	injury	injury	NOUN
ecj-12310	328	11	treated	treat	VERB
ecj-12310	328	12	with	with	ADP
ecj-12310	328	13	brain	brain	NOUN
ecj-12310	328	14	tissue	tissue	NOUN
ecj-12310	328	15	oxygen	oxygen	NOUN
ecj-12310	328	16	monitoring	monitoring	NOUN
ecj-12310	328	17	.	.	PUNCT
ecj-12310	329	1	j	j	PROPN
ecj-12310	329	2	neurosurg	neurosurg	PROPN
ecj-12310	329	3	2005;103:805	2005;103:805	NUM
ecj-12310	329	4	-	-	SYM
ecj-12310	329	5	81	81	NUM
ecj-12310	329	6	.	.	PUNCT
ecj-12310	329	7	68	68	NUM
ecj-12310	329	8	.	.	X
ecj-12310	329	9	de	de	AUX
ecj-12310	329	10	vivo	vivo	NOUN
ecj-12310	329	11	a	a	PRON
ecj-12310	329	12	,	,	PUNCT
ecj-12310	329	13	del	del	X
ecj-12310	329	14	gaudio	gaudio	NOUN
ecj-12310	329	15	p	p	X
ecj-12310	329	16	,	,	PUNCT
ecj-12310	329	17	ciritella	ciritella	PROPN
ecj-12310	329	18	m	m	PROPN
ecj-12310	329	19	,	,	PUNCT
ecj-12310	329	20	et	et	PROPN
ecj-12310	329	21	al	al	PROPN
ecj-12310	329	22	.	.	PUNCT
ecj-12310	329	23	hypertonic	hypertonic	ADJ
ecj-12310	329	24	saline	saline	NOUN
ecj-12310	329	25	solution	solution	NOUN
ecj-12310	329	26	:	:	PUNCT
ecj-12310	329	27	a	a	DET
ecj-12310	329	28	safe	safe	ADJ
ecj-12310	329	29	alternative	alternative	NOUN
ecj-12310	329	30	to	to	ADP
ecj-12310	329	31	mannitol	mannitol	NOUN
ecj-12310	329	32	18	18	NUM
ecj-12310	329	33	%	%	NOUN
ecj-12310	329	34	in	in	ADP
ecj-12310	329	35	neurosurgery	neurosurgery	NOUN
ecj-12310	329	36	.	.	PUNCT
ecj-12310	330	1	miner	miner	NOUN
ecj-12310	330	2	anesthesiol	anesthesiol	PROPN
ecj-12310	330	3	2001;67:603	2001;67:603	PROPN
ecj-12310	330	4	-	-	SYM
ecj-12310	330	5	11	11	NUM
ecj-12310	330	6	.	.	PUNCT
ecj-12310	330	7	69	69	NUM
ecj-12310	330	8	.	.	PUNCT
ecj-12310	331	1	gemma	gemma	PROPN
ecj-12310	331	2	s	s	PROPN
ecj-12310	331	3	,	,	PUNCT
ecj-12310	331	4	cozzi	cozzi	NOUN
ecj-12310	331	5	c	c	NOUN
ecj-12310	331	6	,	,	PUNCT
ecj-12310	331	7	tommasino	tommasino	PROPN
ecj-12310	331	8	m	m	PROPN
ecj-12310	331	9	,	,	PUNCT
ecj-12310	331	10	et	et	PROPN
ecj-12310	331	11	al	al	PROPN
ecj-12310	331	12	.	.	PROPN
ecj-12310	331	13	75	75	NUM
ecj-12310	331	14	%	%	NOUN
ecj-12310	331	15	hypertonic	hypertonic	ADJ
ecj-12310	331	16	saline	saline	NOUN
ecj-12310	331	17	versus	versus	ADP
ecj-12310	331	18	20	20	NUM
ecj-12310	331	19	%	%	NOUN
ecj-12310	331	20	mannitol	mannitol	NOUN
ecj-12310	331	21	during	during	ADP
ecj-12310	331	22	elective	elective	ADJ
ecj-12310	331	23	neurosurgical	neurosurgical	ADJ
ecj-12310	331	24	supratentorial	supratentorial	ADJ
ecj-12310	331	25	procedures	procedure	NOUN
ecj-12310	331	26	.	.	PUNCT
ecj-12310	332	1	j	j	PROPN
ecj-12310	332	2	neurosurg	neurosurg	PROPN
ecj-12310	332	3	anesthesiol	anesthesiol	PROPN
ecj-12310	332	4	1997;9:329	1997;9:329	PROPN
ecj-12310	332	5	-	-	SYM
ecj-12310	332	6	34	34	NUM
ecj-12310	332	7	.	.	PUNCT
ecj-12310	332	8	70	70	NUM
ecj-12310	332	9	.	.	PUNCT
ecj-12310	333	1	vialet	vialet	NOUN
ecj-12310	333	2	r	r	NOUN
ecj-12310	333	3	,	,	PUNCT
ecj-12310	333	4	albanèse	albanèse	PROPN
ecj-12310	333	5	j	j	PROPN
ecj-12310	333	6	,	,	PUNCT
ecj-12310	333	7	thomachot	thomachot	PROPN
ecj-12310	333	8	l	l	NOUN
ecj-12310	333	9	,	,	PUNCT
ecj-12310	333	10	et	et	PROPN
ecj-12310	333	11	al	al	PROPN
ecj-12310	333	12	.	.	PROPN
ecj-12310	333	13	isovolume	isovolume	ADJ
ecj-12310	333	14	hypertonic	hypertonic	ADJ
ecj-12310	333	15	solutes	solute	NOUN
ecj-12310	333	16	(	(	PUNCT
ecj-12310	333	17	sodium	sodium	NOUN
ecj-12310	333	18	chloride	chloride	NOUN
ecj-12310	333	19	or	or	CCONJ
ecj-12310	333	20	mannitol	mannitol	NOUN
ecj-12310	333	21	)	)	PUNCT
ecj-12310	333	22	in	in	ADP
ecj-12310	333	23	the	the	DET
ecj-12310	333	24	treatment	treatment	NOUN
ecj-12310	333	25	of	of	ADP
ecj-12310	333	26	refractory	refractory	NOUN
ecj-12310	333	27	posttraumatic	posttraumatic	ADJ
ecj-12310	333	28	intracranial	intracranial	ADJ
ecj-12310	333	29	hypertension	hypertension	NOUN
ecj-12310	333	30	:	:	PUNCT
ecj-12310	333	31	2	2	NUM
ecj-12310	333	32	ml	ml	NOUN
ecj-12310	333	33	/	/	SYM
ecj-12310	333	34	kg	kg	PROPN
ecj-12310	333	35	75	75	NUM
ecj-12310	333	36	%	%	NOUN
ecj-12310	333	37	saline	saline	NOUN
ecj-12310	333	38	is	be	AUX
ecj-12310	333	39	more	more	ADV
ecj-12310	333	40	effective	effective	ADJ
ecj-12310	333	41	than	than	ADP
ecj-12310	333	42	2	2	NUM
ecj-12310	333	43	ml	ml	NOUN
ecj-12310	333	44	/	/	SYM
ecj-12310	333	45	kg	kg	PROPN
ecj-12310	333	46	20	20	NUM
ecj-12310	333	47	%	%	NOUN
ecj-12310	333	48	mannitol	mannitol	NOUN
ecj-12310	333	49	.	.	PUNCT
ecj-12310	334	1	critical	critical	ADJ
ecj-12310	334	2	care	care	NOUN
ecj-12310	334	3	med	me	VERB
ecj-12310	334	4	2003;31:1683–7	2003;31:1683–7	NOUN
ecj-12310	334	5	.	.	PUNCT
ecj-12310	335	1	71	71	NUM
ecj-12310	335	2	.	.	PUNCT
ecj-12310	335	3	harutjunyan	harutjunyan	ADJ
ecj-12310	335	4	l	l	PROPN
ecj-12310	335	5	,	,	PUNCT
ecj-12310	335	6	holz	holz	PROPN
ecj-12310	335	7	c	c	PROPN
ecj-12310	335	8	,	,	PUNCT
ecj-12310	335	9	rieger	rieger	PROPN
ecj-12310	335	10	a	a	PROPN
ecj-12310	335	11	,	,	PUNCT
ecj-12310	335	12	et	et	PROPN
ecj-12310	335	13	al	al	PROPN
ecj-12310	335	14	.	.	PUNCT
ecj-12310	335	15	efficiency	efficiency	NOUN
ecj-12310	335	16	of	of	ADP
ecj-12310	335	17	7.2	7.2	NUM
ecj-12310	335	18	%	%	NOUN
ecj-12310	335	19	hypertonic	hypertonic	ADJ
ecj-12310	335	20	saline	saline	NOUN
ecj-12310	335	21	hydroxyethyl	hydroxyethyl	NOUN
ecj-12310	335	22	starch	starch	NOUN
ecj-12310	335	23	200/0.5	200/0.5	NUM
ecj-12310	335	24	vs.	vs.	ADP
ecj-12310	335	25	mannitol	mannitol	NOUN
ecj-12310	335	26	15	15	NUM
ecj-12310	335	27	%	%	NOUN
ecj-12310	335	28	in	in	ADP
ecj-12310	335	29	the	the	DET
ecj-12310	335	30	treatment	treatment	NOUN
ecj-12310	335	31	of	of	ADP
ecj-12310	335	32	increased	increase	VERB
ecj-12310	335	33	intracranial	intracranial	ADJ
ecj-12310	335	34	pressure	pressure	NOUN
ecj-12310	335	35	in	in	ADP
ecj-12310	335	36	neurosurgical	neurosurgical	ADJ
ecj-12310	335	37	patients	patient	NOUN
ecj-12310	335	38	–	–	PUNCT
ecj-12310	335	39	a	a	DET
ecj-12310	335	40	randomized	randomized	ADJ
ecj-12310	335	41	clinical	clinical	ADJ
ecj-12310	335	42	trial	trial	NOUN
ecj-12310	335	43	[	[	X
ecj-12310	335	44	isrctn62699180	isrctn62699180	X
ecj-12310	335	45	]	]	PUNCT
ecj-12310	335	46	.	.	PUNCT
ecj-12310	336	1	critical	critical	ADJ
ecj-12310	336	2	care	care	NOUN
ecj-12310	336	3	2005;9:1–11	2005;9:1–11	NUM
ecj-12310	336	4	.	.	PUNCT
ecj-12310	336	5	72	72	NUM
ecj-12310	336	6	.	.	PUNCT
ecj-12310	337	1	francony	francony	PROPN
ecj-12310	337	2	g	g	PROPN
ecj-12310	337	3	,	,	PUNCT
ecj-12310	337	4	fauvage	fauvage	NOUN
ecj-12310	337	5	b	b	NOUN
ecj-12310	337	6	,	,	PUNCT
ecj-12310	337	7	falcon	falcon	PROPN
ecj-12310	337	8	d	d	PROPN
ecj-12310	337	9	,	,	PUNCT
ecj-12310	337	10	et	et	PROPN
ecj-12310	337	11	al	al	PROPN
ecj-12310	337	12	.	.	PUNCT
ecj-12310	337	13	equimolar	equimolar	PROPN
ecj-12310	337	14	doses	dose	NOUN
ecj-12310	337	15	of	of	ADP
ecj-12310	337	16	mannitol	mannitol	NOUN
ecj-12310	337	17	and	and	CCONJ
ecj-12310	337	18	hypertonic	hypertonic	ADJ
ecj-12310	337	19	saline	saline	NOUN
ecj-12310	337	20	in	in	ADP
ecj-12310	337	21	the	the	DET
ecj-12310	337	22	treatment	treatment	NOUN
ecj-12310	337	23	of	of	ADP
ecj-12310	337	24	increased	increase	VERB
ecj-12310	337	25	intracranial	intracranial	ADJ
ecj-12310	337	26	pressure	pressure	NOUN
ecj-12310	337	27	.	.	PUNCT
ecj-12310	338	1	crit	crit	PROPN
ecj-12310	338	2	care	care	NOUN
ecj-12310	338	3	med	med	PROPN
ecj-12310	338	4	2008;36:795–800	2008;36:795–800	NUM
ecj-12310	338	5	.	.	PUNCT
ecj-12310	339	1	73	73	NUM
ecj-12310	339	2	.	.	PUNCT
ecj-12310	340	1	oddo	oddo	PROPN
ecj-12310	340	2	m	m	PROPN
ecj-12310	340	3	,	,	PUNCT
ecj-12310	340	4	levine	levine	PROPN
ecj-12310	340	5	jm	jm	PROPN
ecj-12310	340	6	,	,	PUNCT
ecj-12310	340	7	frangos	frangos	PROPN
ecj-12310	340	8	s	s	PROPN
ecj-12310	340	9	,	,	PUNCT
ecj-12310	340	10	et	et	PROPN
ecj-12310	340	11	al	al	PROPN
ecj-12310	340	12	.	.	PROPN
ecj-12310	340	13	effect	effect	NOUN
ecj-12310	340	14	of	of	ADP
ecj-12310	340	15	mannitol	mannitol	NOUN
ecj-12310	340	16	and	and	CCONJ
ecj-12310	340	17	hypertonic	hypertonic	ADJ
ecj-12310	340	18	saline	saline	NOUN
ecj-12310	340	19	on	on	ADP
ecj-12310	340	20	cerebral	cerebral	ADJ
ecj-12310	340	21	oxygenation	oxygenation	NOUN
ecj-12310	340	22	in	in	ADP
ecj-12310	340	23	patients	patient	NOUN
ecj-12310	340	24	with	with	ADP
ecj-12310	340	25	severe	severe	ADJ
ecj-12310	340	26	traumatic	traumatic	ADJ
ecj-12310	340	27	brain	brain	NOUN
ecj-12310	340	28	injury	injury	NOUN
ecj-12310	340	29	and	and	CCONJ
ecj-12310	340	30	refractory	refractory	NOUN
ecj-12310	340	31	intracranial	intracranial	ADJ
ecj-12310	340	32	hypertension	hypertension	NOUN
ecj-12310	340	33	.	.	PUNCT
ecj-12310	341	1	j	j	PROPN
ecj-12310	341	2	neurol	neurol	PROPN
ecj-12310	341	3	neurosurg	neurosurg	PROPN
ecj-12310	341	4	psychiatry	psychiatry	PROPN
ecj-12310	341	5	2009;80:916–20	2009;80:916–20	PRON
ecj-12310	341	6	.	.	PROPN
ecj-12310	342	1	74	74	NUM
ecj-12310	342	2	.	.	PUNCT
ecj-12310	343	1	kerwin	kerwin	PROPN
ecj-12310	343	2	aj	aj	PROPN
ecj-12310	343	3	,	,	PUNCT
ecj-12310	343	4	schinco	schinco	PROPN
ecj-12310	343	5	ma	ma	PROPN
ecj-12310	343	6	,	,	PUNCT
ecj-12310	343	7	tepas	tepas	PROPN
ecj-12310	343	8	iii	iii	PROPN
ecj-12310	343	9	jj	jj	PROPN
ecj-12310	343	10	,	,	PUNCT
ecj-12310	343	11	et	et	PROPN
ecj-12310	343	12	al	al	PROPN
ecj-12310	343	13	.	.	PUNCT
ecj-12310	344	1	the	the	DET
ecj-12310	344	2	use	use	NOUN
ecj-12310	344	3	of	of	ADP
ecj-12310	344	4	234	234	NUM
ecj-12310	344	5	%	%	NOUN
ecj-12310	344	6	hypertonic	hypertonic	ADJ
ecj-12310	344	7	saline	saline	NOUN
ecj-12310	344	8	for	for	ADP
ecj-12310	344	9	the	the	DET
ecj-12310	344	10	management	management	NOUN
ecj-12310	344	11	of	of	ADP
ecj-12310	344	12	elevated	elevated	ADJ
ecj-12310	344	13	intracranial	intracranial	ADJ
ecj-12310	344	14	pressure	pressure	NOUN
ecj-12310	344	15	in	in	ADP
ecj-12310	344	16	patients	patient	NOUN
ecj-12310	344	17	with	with	ADP
ecj-12310	344	18	severe	severe	ADJ
ecj-12310	344	19	traumatic	traumatic	ADJ
ecj-12310	344	20	brain	brain	NOUN
ecj-12310	344	21	injury	injury	NOUN
ecj-12310	344	22	:	:	PUNCT
ecj-12310	344	23	a	a	DET
ecj-12310	344	24	pilot	pilot	NOUN
ecj-12310	344	25	review	review	NOUN
ecj-12310	344	26	[	[	X
ecj-12310	344	27	emergency	emergency	NOUN
ecj-12310	344	28	care	care	NOUN
ecj-12310	344	29	journal	journal	PROPN
ecj-12310	344	30	2024	2024	NUM
ecj-12310	344	31	;	;	PUNCT
ecj-12310	344	32	20:12310	20:12310	NUM
ecj-12310	344	33	]	]	X
ecj-12310	345	1	[	[	X
ecj-12310	345	2	page	page	NOUN
ecj-12310	345	3	36	36	NUM
ecj-12310	345	4	]	]	PUNCT
ecj-12310	345	5	non	non	ADJ
ecj-12310	345	6	-co	-co	PROPN
ecj-12310	345	7	mmerc	mmerc	PROPN
ecj-12310	345	8	ial	ial	PROPN
ecj-12310	345	9	us	us	PROPN
ecj-12310	346	1	e	e	NOUN
ecj-12310	346	2	o	o	NOUN
ecj-12310	346	3	nly	nly	ADV
ecj-12310	346	4	study	study	VERB
ecj-12310	346	5	.	.	PUNCT
ecj-12310	347	1	j	j	PROPN
ecj-12310	347	2	trauma	trauma	PROPN
ecj-12310	347	3	acute	acute	PROPN
ecj-12310	347	4	care	care	NOUN
ecj-12310	347	5	surg	surg	NOUN
ecj-12310	347	6	.	.	PUNCT
ecj-12310	348	1	(	(	PUNCT
ecj-12310	348	2	2009	2009	NUM
ecj-12310	348	3	)	)	PUNCT
ecj-12310	348	4	67:277–82	67:277–82	NOUN
ecj-12310	348	5	.	.	PUNCT
ecj-12310	349	1	75	75	NUM
ecj-12310	349	2	.	.	PUNCT
ecj-12310	349	3	mangat	mangat	PROPN
ecj-12310	349	4	hs	hs	PROPN
ecj-12310	349	5	,	,	PUNCT
ecj-12310	349	6	wu	wu	PROPN
ecj-12310	349	7	x	x	PROPN
ecj-12310	349	8	,	,	PUNCT
ecj-12310	349	9	gerber	gerber	PROPN
ecj-12310	349	10	lm	lm	PROPN
ecj-12310	349	11	,	,	PUNCT
ecj-12310	349	12	et	et	PROPN
ecj-12310	349	13	al	al	PROPN
ecj-12310	349	14	.	.	PUNCT
ecj-12310	350	1	hypertonic	hypertonic	ADJ
ecj-12310	350	2	saline	saline	NOUN
ecj-12310	350	3	is	be	AUX
ecj-12310	350	4	superior	superior	ADJ
ecj-12310	350	5	to	to	ADP
ecj-12310	350	6	mannitol	mannitol	NOUN
ecj-12310	350	7	for	for	ADP
ecj-12310	350	8	the	the	DET
ecj-12310	350	9	combined	combined	ADJ
ecj-12310	350	10	effect	effect	NOUN
ecj-12310	350	11	on	on	ADP
ecj-12310	350	12	intracranial	intracranial	ADJ
ecj-12310	350	13	pressure	pressure	NOUN
ecj-12310	350	14	and	and	CCONJ
ecj-12310	350	15	cerebral	cerebral	ADJ
ecj-12310	350	16	perfusion	perfusion	NOUN
ecj-12310	350	17	pressure	pressure	NOUN
ecj-12310	350	18	burdens	burden	NOUN
ecj-12310	350	19	in	in	ADP
ecj-12310	350	20	patients	patient	NOUN
ecj-12310	350	21	with	with	ADP
ecj-12310	350	22	severe	severe	ADJ
ecj-12310	350	23	traumatic	traumatic	ADJ
ecj-12310	350	24	brain	brain	NOUN
ecj-12310	350	25	injury	injury	NOUN
ecj-12310	350	26	.	.	PUNCT
ecj-12310	351	1	neurosurgery	neurosurgery	NOUN
ecj-12310	351	2	2020;86:221–30	2020;86:221–30	NUM
ecj-12310	351	3	.	.	PROPN
ecj-12310	352	1	76	76	NUM
ecj-12310	352	2	.	.	PUNCT
ecj-12310	353	1	huang	huang	PROPN
ecj-12310	353	2	x	x	PROPN
ecj-12310	353	3	,	,	PUNCT
ecj-12310	353	4	yang	yang	PROPN
ecj-12310	353	5	l	l	PROPN
ecj-12310	353	6	,	,	PUNCT
ecj-12310	353	7	ye	ye	PROPN
ecj-12310	353	8	j	j	PROPN
ecj-12310	353	9	,	,	PUNCT
ecj-12310	353	10	et	et	PROPN
ecj-12310	353	11	al	al	PROPN
ecj-12310	353	12	.	.	PUNCT
ecj-12310	353	13	equimolar	equimolar	PROPN
ecj-12310	353	14	doses	dose	NOUN
ecj-12310	353	15	of	of	ADP
ecj-12310	353	16	hypertonic	hypertonic	ADJ
ecj-12310	353	17	agents	agent	NOUN
ecj-12310	353	18	(	(	PUNCT
ecj-12310	353	19	saline	saline	NOUN
ecj-12310	353	20	or	or	CCONJ
ecj-12310	353	21	mannitol	mannitol	NOUN
ecj-12310	353	22	)	)	PUNCT
ecj-12310	353	23	in	in	ADP
ecj-12310	353	24	the	the	DET
ecj-12310	353	25	treatment	treatment	NOUN
ecj-12310	353	26	of	of	ADP
ecj-12310	353	27	intracranial	intracranial	ADJ
ecj-12310	353	28	hypertension	hypertension	NOUN
ecj-12310	353	29	after	after	ADP
ecj-12310	353	30	severe	severe	ADJ
ecj-12310	353	31	traumatic	traumatic	ADJ
ecj-12310	353	32	brain	brain	NOUN
ecj-12310	353	33	injury	injury	NOUN
ecj-12310	353	34	.	.	PUNCT
ecj-12310	354	1	medicine	medicine	NOUN
ecj-12310	354	2	2020;99:38	2020;99:38	NUM
ecj-12310	354	3	.	.	PUNCT
ecj-12310	355	1	77	77	NUM
ecj-12310	355	2	.	.	PUNCT
ecj-12310	356	1	jagannatha	jagannatha	PROPN
ecj-12310	356	2	at	at	ADP
ecj-12310	356	3	,	,	PUNCT
ecj-12310	356	4	sriganesh	sriganesh	ADJ
ecj-12310	356	5	k	k	PROPN
ecj-12310	356	6	,	,	PUNCT
ecj-12310	356	7	devi	devi	PROPN
ecj-12310	356	8	bi	bi	PROPN
ecj-12310	356	9	,	,	PUNCT
ecj-12310	356	10	rao	rao	PROPN
ecj-12310	356	11	gsu	gsu	NOUN
ecj-12310	356	12	.	.	PUNCT
ecj-12310	357	1	an	an	DET
ecj-12310	357	2	equiosmolar	equiosmolar	ADJ
ecj-12310	357	3	study	study	NOUN
ecj-12310	357	4	on	on	ADP
ecj-12310	357	5	early	early	ADJ
ecj-12310	357	6	intracranial	intracranial	ADJ
ecj-12310	357	7	physiology	physiology	NOUN
ecj-12310	357	8	and	and	CCONJ
ecj-12310	357	9	long	long	ADJ
ecj-12310	357	10	term	term	NOUN
ecj-12310	357	11	outcome	outcome	NOUN
ecj-12310	357	12	in	in	ADP
ecj-12310	357	13	severe	severe	ADJ
ecj-12310	357	14	traumatic	traumatic	ADJ
ecj-12310	357	15	brain	brain	NOUN
ecj-12310	357	16	injury	injury	NOUN
ecj-12310	357	17	comparing	compare	VERB
ecj-12310	357	18	mannitol	mannitol	NOUN
ecj-12310	357	19	and	and	CCONJ
ecj-12310	357	20	hypertonic	hypertonic	ADJ
ecj-12310	357	21	saline	saline	NOUN
ecj-12310	357	22	.	.	PUNCT
ecj-12310	358	1	j	j	PROPN
ecj-12310	358	2	clinic	clinic	PROPN
ecj-12310	358	3	neuroscience	neuroscience	NOUN
ecj-12310	358	4	2016;27:68–73	2016;27:68–73	NUM
ecj-12310	358	5	.	.	PUNCT
ecj-12310	359	1	review	review	NOUN
ecj-12310	360	1	[	[	X
ecj-12310	360	2	page	page	NOUN
ecj-12310	360	3	37	37	NUM
ecj-12310	360	4	]	]	PUNCT
ecj-12310	361	1	[	[	X
ecj-12310	361	2	emergency	emergency	NOUN
ecj-12310	361	3	care	care	NOUN
ecj-12310	361	4	journal	journal	PROPN
ecj-12310	361	5	2024	2024	NUM
ecj-12310	361	6	;	;	PUNCT
ecj-12310	361	7	20:12310	20:12310	NUM
ecj-12310	361	8	]	]	X
ecj-12310	361	9	online	online	ADJ
ecj-12310	361	10	supplementary	supplementary	ADJ
ecj-12310	361	11	material	material	NOUN
ecj-12310	361	12	:	:	PUNCT
ecj-12310	361	13	table	table	NOUN
ecj-12310	361	14	1	1	NUM
ecj-12310	361	15	.	.	PUNCT
ecj-12310	361	16	clinical	clinical	ADJ
ecj-12310	361	17	evidence	evidence	NOUN
ecj-12310	361	18	comparing	compare	VERB
ecj-12310	361	19	hypertonic	hypertonic	ADJ
ecj-12310	361	20	saline	saline	NOUN
ecj-12310	361	21	and	and	CCONJ
ecj-12310	361	22	mannitol	mannitol	NOUN
ecj-12310	361	23	.	.	PUNCT
ecj-12310	361	24	table	table	NOUN
ecj-12310	361	25	2	2	NUM
ecj-12310	361	26	.	.	PUNCT
ecj-12310	361	27	summarising	summarise	VERB
ecj-12310	361	28	the	the	DET
ecj-12310	361	29	comparison	comparison	NOUN
ecj-12310	361	30	of	of	ADP
ecj-12310	361	31	safety	safety	NOUN
ecj-12310	361	32	efficacy	efficacy	NOUN
ecj-12310	361	33	profile	profile	NOUN
ecj-12310	361	34	of	of	ADP
ecj-12310	361	35	mannitol	mannitol	NOUN
ecj-12310	361	36	and	and	CCONJ
ecj-12310	361	37	hypertonic	hypertonic	ADJ
ecj-12310	361	38	saline	saline	NOUN
ecj-12310	361	39	.	.	PUNCT
ecj-12310	362	1	non	non	ADJ
ecj-12310	362	2	-co	-co	PROPN
ecj-12310	362	3	mmerc	mmerc	PROPN
ecj-12310	362	4	ial	ial	PROPN
ecj-12310	362	5	us	us	PROPN
ecj-12310	362	6	e	e	NOUN
ecj-12310	362	7	o	o	NOUN
ecj-12310	362	8	nly	nly	ADV