id	sid	tid	token	lemma	pos
ecj-13110	1	1	hrev_master	hrev_master	NOUN
ecj-13110	1	2	abstract	abstract	ADJ
ecj-13110	1	3	drug	drug	NOUN
ecj-13110	1	4	-	-	PUNCT
ecj-13110	1	5	related	relate	VERB
ecj-13110	1	6	deaths	death	NOUN
ecj-13110	1	7	in	in	ADP
ecj-13110	1	8	italy	italy	PROPN
ecj-13110	1	9	,	,	PUNCT
ecj-13110	1	10	especially	especially	ADV
ecj-13110	1	11	from	from	ADP
ecj-13110	1	12	opioid	opioid	ADJ
ecj-13110	1	13	overdoses	overdose	NOUN
ecj-13110	1	14	,	,	PUNCT
ecj-13110	1	15	increased	increase	VERB
ecj-13110	1	16	by	by	ADP
ecj-13110	1	17	6	6	NUM
ecj-13110	1	18	%	%	NOUN
ecj-13110	1	19	among	among	ADP
ecj-13110	1	20	individuals	individual	NOUN
ecj-13110	1	21	aged	age	VERB
ecj-13110	1	22	15	15	NUM
ecj-13110	1	23	-	-	SYM
ecj-13110	1	24	34	34	NUM
ecj-13110	1	25	from	from	ADP
ecj-13110	1	26	2014	2014	NUM
ecj-13110	1	27	to	to	ADP
ecj-13110	1	28	2018	2018	NUM
ecj-13110	1	29	.	.	PUNCT
ecj-13110	2	1	opioid	opioid	NOUN
ecj-13110	2	2	-	-	PUNCT
ecj-13110	2	3	related	relate	VERB
ecj-13110	2	4	deaths	death	NOUN
ecj-13110	2	5	rose	rise	VERB
ecj-13110	2	6	by	by	ADP
ecj-13110	2	7	6.6	6.6	NUM
ecj-13110	2	8	%	%	NOUN
ecj-13110	2	9	in	in	ADP
ecj-13110	2	10	the	the	DET
ecj-13110	2	11	15	15	NUM
ecj-13110	2	12	-	-	SYM
ecj-13110	2	13	24	24	NUM
ecj-13110	2	14	age	age	NOUN
ecj-13110	2	15	group	group	NOUN
ecj-13110	2	16	and	and	CCONJ
ecj-13110	2	17	by	by	ADP
ecj-13110	2	18	5.4	5.4	NUM
ecj-13110	2	19	%	%	NOUN
ecj-13110	2	20	in	in	ADP
ecj-13110	2	21	the	the	DET
ecj-13110	2	22	25	25	NUM
ecj-13110	2	23	-	-	SYM
ecj-13110	2	24	34	34	NUM
ecj-13110	2	25	age	age	NOUN
ecj-13110	2	26	group	group	NOUN
ecj-13110	2	27	during	during	ADP
ecj-13110	2	28	this	this	DET
ecj-13110	2	29	period	period	NOUN
ecj-13110	2	30	.	.	PUNCT
ecj-13110	3	1	there	there	PRON
ecj-13110	3	2	is	be	VERB
ecj-13110	3	3	limited	limited	ADJ
ecj-13110	3	4	data	datum	NOUN
ecj-13110	3	5	on	on	ADP
ecj-13110	3	6	the	the	DET
ecj-13110	3	7	effectiveness	effectiveness	NOUN
ecj-13110	3	8	of	of	ADP
ecj-13110	3	9	different	different	ADJ
ecj-13110	3	10	naloxone	naloxone	ADJ
ecj-13110	3	11	administration	administration	NOUN
ecj-13110	3	12	routes	route	NOUN
ecj-13110	3	13	—	—	PUNCT
ecj-13110	3	14	intranasal	intranasal	NOUN
ecj-13110	3	15	(	(	PUNCT
ecj-13110	3	16	in	in	ADP
ecj-13110	3	17	)	)	PUNCT
ecj-13110	3	18	,	,	PUNCT
ecj-13110	3	19	intramuscular	intramuscular	ADV
ecj-13110	3	20	(	(	PUNCT
ecj-13110	3	21	i	i	NOUN
ecj-13110	3	22	m	m	PROPN
ecj-13110	3	23	)	)	PUNCT
ecj-13110	3	24	,	,	PUNCT
ecj-13110	3	25	and	and	CCONJ
ecj-13110	3	26	intravenous	intravenous	ADJ
ecj-13110	3	27	(	(	PUNCT
ecj-13110	3	28	iv)—and	iv)—and	NOUN
ecj-13110	3	29	no	no	PRON
ecj-13110	3	30	established	establish	VERB
ecj-13110	3	31	guidelines	guideline	NOUN
ecj-13110	3	32	for	for	ADP
ecj-13110	3	33	prehospital	prehospital	ADJ
ecj-13110	3	34	overdose	overdose	NOUN
ecj-13110	3	35	management	management	NOUN
ecj-13110	3	36	.	.	PUNCT
ecj-13110	4	1	timely	timely	ADJ
ecj-13110	4	2	intervention	intervention	NOUN
ecj-13110	4	3	is	be	AUX
ecj-13110	4	4	crucial	crucial	ADJ
ecj-13110	4	5	to	to	PART
ecj-13110	4	6	reduce	reduce	VERB
ecj-13110	4	7	overdose	overdose	ADJ
ecj-13110	4	8	mortality	mortality	NOUN
ecj-13110	4	9	.	.	PUNCT
ecj-13110	5	1	this	this	DET
ecj-13110	5	2	review	review	NOUN
ecj-13110	5	3	aims	aim	VERB
ecj-13110	5	4	to	to	PART
ecj-13110	5	5	assess	assess	VERB
ecj-13110	5	6	the	the	DET
ecj-13110	5	7	effectiveness	effectiveness	NOUN
ecj-13110	5	8	of	of	ADP
ecj-13110	5	9	naloxone	naloxone	ADJ
ecj-13110	5	10	administration	administration	NOUN
ecj-13110	5	11	methods	method	NOUN
ecj-13110	5	12	in	in	ADP
ecj-13110	5	13	opioid	opioid	ADJ
ecj-13110	5	14	overdoses	overdose	NOUN
ecj-13110	5	15	,	,	PUNCT
ecj-13110	5	16	focusing	focus	VERB
ecj-13110	5	17	on	on	ADP
ecj-13110	5	18	prehospital	prehospital	ADJ
ecj-13110	5	19	settings	setting	NOUN
ecj-13110	5	20	and	and	CCONJ
ecj-13110	5	21	comparing	compare	VERB
ecj-13110	5	22	in	in	ADP
ecj-13110	5	23	,	,	PUNCT
ecj-13110	5	24	i	i	PRON
ecj-13110	5	25	m	m	PROPN
ecj-13110	5	26	,	,	PUNCT
ecj-13110	5	27	and	and	CCONJ
ecj-13110	5	28	iv	iv	NUM
ecj-13110	5	29	routes	route	NOUN
ecj-13110	5	30	.	.	PUNCT
ecj-13110	6	1	a	a	DET
ecj-13110	6	2	narrative	narrative	ADJ
ecj-13110	6	3	review	review	NOUN
ecj-13110	6	4	was	be	AUX
ecj-13110	6	5	conducted	conduct	VERB
ecj-13110	6	6	in	in	ADP
ecj-13110	6	7	accordance	accordance	NOUN
ecj-13110	6	8	with	with	ADP
ecj-13110	6	9	prisma	prisma	PROPN
ecj-13110	6	10	guidelines	guideline	NOUN
ecj-13110	6	11	.	.	PUNCT
ecj-13110	7	1	the	the	DET
ecj-13110	7	2	search	search	NOUN
ecj-13110	7	3	included	include	VERB
ecj-13110	7	4	terms	term	NOUN
ecj-13110	7	5	such	such	ADJ
ecj-13110	7	6	as	as	ADP
ecj-13110	7	7	“	"	PUNCT
ecj-13110	7	8	naloxone	naloxone	NOUN
ecj-13110	7	9	,	,	PUNCT
ecj-13110	7	10	”	"	PUNCT
ecj-13110	7	11	“	"	PUNCT
ecj-13110	7	12	opioid	opioid	ADJ
ecj-13110	7	13	overdose	overdose	ADV
ecj-13110	7	14	,	,	PUNCT
ecj-13110	7	15	”	"	PUNCT
ecj-13110	7	16	“	"	PUNCT
ecj-13110	7	17	intranasal	intranasal	ADJ
ecj-13110	7	18	administration	administration	NOUN
ecj-13110	7	19	,	,	PUNCT
ecj-13110	7	20	”	"	PUNCT
ecj-13110	7	21	and	and	CCONJ
ecj-13110	7	22	“	"	PUNCT
ecj-13110	7	23	prehospital	prehospital	ADJ
ecj-13110	7	24	emergency	emergency	NOUN
ecj-13110	7	25	care	care	NOUN
ecj-13110	7	26	,	,	PUNCT
ecj-13110	7	27	”	"	PUNCT
ecj-13110	7	28	with	with	ADP
ecj-13110	7	29	boolean	boolean	ADJ
ecj-13110	7	30	operators	operator	NOUN
ecj-13110	7	31	to	to	PART
ecj-13110	7	32	refine	refine	VERB
ecj-13110	7	33	the	the	DET
ecj-13110	7	34	scope	scope	NOUN
ecj-13110	7	35	.	.	PUNCT
ecj-13110	8	1	the	the	DET
ecj-13110	8	2	study	study	NOUN
ecj-13110	8	3	selection	selection	NOUN
ecj-13110	8	4	was	be	AUX
ecj-13110	8	5	guided	guide	VERB
ecj-13110	8	6	by	by	ADP
ecj-13110	8	7	the	the	DET
ecj-13110	8	8	pico	pico	NOUN
ecj-13110	8	9	framework	framework	NOUN
ecj-13110	8	10	(	(	PUNCT
ecj-13110	8	11	population	population	NOUN
ecj-13110	8	12	,	,	PUNCT
ecj-13110	8	13	intervention	intervention	NOUN
ecj-13110	8	14	,	,	PUNCT
ecj-13110	8	15	comparison	comparison	NOUN
ecj-13110	8	16	,	,	PUNCT
ecj-13110	8	17	outcome	outcome	NOUN
ecj-13110	8	18	)	)	PUNCT
ecj-13110	8	19	.	.	PUNCT
ecj-13110	9	1	studies	study	NOUN
ecj-13110	9	2	were	be	AUX
ecj-13110	9	3	assessed	assess	VERB
ecj-13110	9	4	for	for	ADP
ecj-13110	9	5	quality	quality	NOUN
ecj-13110	9	6	using	use	VERB
ecj-13110	9	7	the	the	DET
ecj-13110	9	8	dixon	dixon	NOUN
ecj-13110	9	9	-	-	PUNCT
ecj-13110	9	10	woods	wood	NOUN
ecj-13110	9	11	tool	tool	NOUN
ecj-13110	9	12	,	,	PUNCT
ecj-13110	9	13	and	and	CCONJ
ecj-13110	9	14	inclusion	inclusion	NOUN
ecj-13110	9	15	/	/	SYM
ecj-13110	9	16	exclusion	exclusion	NOUN
ecj-13110	9	17	criteria	criterion	NOUN
ecj-13110	9	18	were	be	AUX
ecj-13110	9	19	applied	apply	VERB
ecj-13110	9	20	.	.	PUNCT
ecj-13110	10	1	studies	study	NOUN
ecj-13110	10	2	will	will	AUX
ecj-13110	10	3	be	be	AUX
ecj-13110	10	4	selected	select	VERB
ecj-13110	10	5	based	base	VERB
ecj-13110	10	6	on	on	ADP
ecj-13110	10	7	populations	population	NOUN
ecj-13110	10	8	treated	treat	VERB
ecj-13110	10	9	with	with	ADP
ecj-13110	10	10	naloxone	naloxone	NOUN
ecj-13110	10	11	administered	administer	VERB
ecj-13110	10	12	via	via	ADP
ecj-13110	10	13	intranasal	intranasal	NOUN
ecj-13110	10	14	,	,	PUNCT
ecj-13110	10	15	intramuscular	intramuscular	ADJ
ecj-13110	10	16	,	,	PUNCT
ecj-13110	10	17	or	or	CCONJ
ecj-13110	10	18	intravenous	intravenous	ADJ
ecj-13110	10	19	routes	route	NOUN
ecj-13110	10	20	,	,	PUNCT
ecj-13110	10	21	focusing	focus	VERB
ecj-13110	10	22	on	on	ADP
ecj-13110	10	23	comparisons	comparison	NOUN
ecj-13110	10	24	between	between	ADP
ecj-13110	10	25	these	these	DET
ecj-13110	10	26	formulations	formulation	NOUN
ecj-13110	10	27	in	in	ADP
ecj-13110	10	28	terms	term	NOUN
ecj-13110	10	29	of	of	ADP
ecj-13110	10	30	onset	onset	NOUN
ecj-13110	10	31	time	time	NOUN
ecj-13110	10	32	and	and	CCONJ
ecj-13110	10	33	intervention	intervention	NOUN
ecj-13110	10	34	effectiveness	effectiveness	NOUN
ecj-13110	10	35	.	.	PUNCT
ecj-13110	11	1	out	out	ADP
ecj-13110	11	2	of	of	ADP
ecj-13110	11	3	111	111	NUM
ecj-13110	11	4	studies	study	NOUN
ecj-13110	11	5	,	,	PUNCT
ecj-13110	11	6	five	five	NUM
ecj-13110	11	7	met	meet	VERB
ecj-13110	11	8	the	the	DET
ecj-13110	11	9	eligibility	eligibility	NOUN
ecj-13110	11	10	criteria	criterion	NOUN
ecj-13110	11	11	.	.	PUNCT
ecj-13110	12	1	these	these	DET
ecj-13110	12	2	studies	study	NOUN
ecj-13110	12	3	showed	show	VERB
ecj-13110	12	4	that	that	SCONJ
ecj-13110	12	5	intranasal	intranasal	NOUN
ecj-13110	12	6	naloxone	naloxone	NOUN
ecj-13110	12	7	achieves	achieve	VERB
ecj-13110	12	8	higher	high	ADJ
ecj-13110	12	9	plasma	plasma	NOUN
ecj-13110	12	10	concentrations	concentration	NOUN
ecj-13110	12	11	than	than	ADP
ecj-13110	12	12	intramuscular	intramuscular	ADJ
ecj-13110	12	13	doses	dose	NOUN
ecj-13110	12	14	but	but	CCONJ
ecj-13110	12	15	with	with	ADP
ecj-13110	12	16	slower	slow	ADJ
ecj-13110	12	17	absorption	absorption	NOUN
ecj-13110	12	18	and	and	CCONJ
ecj-13110	12	19	longer	long	ADJ
ecj-13110	12	20	peak	peak	VERB
ecj-13110	12	21	times	time	NOUN
ecj-13110	12	22	.	.	PUNCT
ecj-13110	13	1	additionally	additionally	ADV
ecj-13110	13	2	,	,	PUNCT
ecj-13110	13	3	intramuscular	intramuscular	ADJ
ecj-13110	13	4	naloxone	naloxone	ADJ
ecj-13110	13	5	results	result	NOUN
ecj-13110	13	6	in	in	ADP
ecj-13110	13	7	faster	fast	ADJ
ecj-13110	13	8	respiratory	respiratory	ADJ
ecj-13110	13	9	recovery	recovery	NOUN
ecj-13110	13	10	and	and	CCONJ
ecj-13110	13	11	requires	require	VERB
ecj-13110	13	12	fewer	few	ADJ
ecj-13110	13	13	doses	dose	NOUN
ecj-13110	13	14	.	.	PUNCT
ecj-13110	14	1	intranasal	intranasal	ADJ
ecj-13110	14	2	naloxone	naloxone	NOUN
ecj-13110	14	3	has	have	VERB
ecj-13110	14	4	a	a	DET
ecj-13110	14	5	bioavailability	bioavailability	NOUN
ecj-13110	14	6	of	of	ADP
ecj-13110	14	7	46.8	46.8	NUM
ecj-13110	14	8	%	%	NOUN
ecj-13110	14	9	to	to	ADP
ecj-13110	14	10	50.8	50.8	NUM
ecj-13110	14	11	%	%	NOUN
ecj-13110	14	12	compared	compare	VERB
ecj-13110	14	13	to	to	ADP
ecj-13110	14	14	intravenous	intravenous	ADJ
ecj-13110	14	15	naloxone	naloxone	NOUN
ecj-13110	14	16	,	,	PUNCT
ecj-13110	14	17	with	with	ADP
ecj-13110	14	18	efficacy	efficacy	NOUN
ecj-13110	14	19	outcomes	outcome	NOUN
ecj-13110	14	20	varying	vary	VERB
ecj-13110	14	21	by	by	ADP
ecj-13110	14	22	administration	administration	NOUN
ecj-13110	14	23	route	route	NOUN
ecj-13110	14	24	.	.	PUNCT
ecj-13110	15	1	the	the	DET
ecj-13110	15	2	review	review	NOUN
ecj-13110	15	3	shows	show	VERB
ecj-13110	15	4	that	that	SCONJ
ecj-13110	15	5	intranasal	intranasal	ADJ
ecj-13110	15	6	naloxone	naloxone	NOUN
ecj-13110	15	7	,	,	PUNCT
ecj-13110	15	8	especially	especially	ADV
ecj-13110	15	9	at	at	ADP
ecj-13110	15	10	a	a	DET
ecj-13110	15	11	2	2	NUM
ecj-13110	15	12	mg	mg	NOUN
ecj-13110	15	13	dose	dose	NOUN
ecj-13110	15	14	,	,	PUNCT
ecj-13110	15	15	achieves	achieve	VERB
ecj-13110	15	16	plasma	plasma	NOUN
ecj-13110	15	17	levels	level	NOUN
ecj-13110	15	18	similar	similar	ADJ
ecj-13110	15	19	to	to	ADP
ecj-13110	15	20	intramuscular	intramuscular	ADJ
ecj-13110	15	21	formulations	formulation	NOUN
ecj-13110	15	22	and	and	CCONJ
ecj-13110	15	23	has	have	AUX
ecj-13110	15	24	linear	linear	ADJ
ecj-13110	15	25	pharmacokinetics	pharmacokinetic	NOUN
ecj-13110	15	26	across	across	ADP
ecj-13110	15	27	dosages	dosage	NOUN
ecj-13110	15	28	.	.	PUNCT
ecj-13110	16	1	while	while	SCONJ
ecj-13110	16	2	its	its	PRON
ecj-13110	16	3	bioavailability	bioavailability	NOUN
ecj-13110	16	4	is	be	AUX
ecj-13110	16	5	lower	low	ADJ
ecj-13110	16	6	(	(	PUNCT
ecj-13110	16	7	46	46	NUM
ecj-13110	16	8	%	%	NOUN
ecj-13110	16	9	to	to	PART
ecj-13110	16	10	50	50	NUM
ecj-13110	16	11	%	%	NOUN
ecj-13110	16	12	)	)	PUNCT
ecj-13110	16	13	compared	compare	VERB
ecj-13110	16	14	to	to	ADP
ecj-13110	16	15	intravenous	intravenous	ADJ
ecj-13110	16	16	administration	administration	NOUN
ecj-13110	16	17	,	,	PUNCT
ecj-13110	16	18	it	it	PRON
ecj-13110	16	19	is	be	AUX
ecj-13110	16	20	a	a	DET
ecj-13110	16	21	safer	safe	ADJ
ecj-13110	16	22	and	and	CCONJ
ecj-13110	16	23	more	more	ADV
ecj-13110	16	24	practical	practical	ADJ
ecj-13110	16	25	option	option	NOUN
ecj-13110	16	26	for	for	ADP
ecj-13110	16	27	non	non	ADJ
ecj-13110	16	28	-	-	ADJ
ecj-13110	16	29	clinical	clinical	ADJ
ecj-13110	16	30	settings	setting	NOUN
ecj-13110	16	31	.	.	PUNCT
ecj-13110	17	1	although	although	SCONJ
ecj-13110	17	2	intramuscular	intramuscular	ADJ
ecj-13110	17	3	and	and	CCONJ
ecj-13110	17	4	intravenous	intravenous	ADJ
ecj-13110	17	5	routes	route	NOUN
ecj-13110	17	6	work	work	VERB
ecj-13110	17	7	faster	fast	ADV
ecj-13110	17	8	,	,	PUNCT
ecj-13110	17	9	the	the	DET
ecj-13110	17	10	slower	slow	ADJ
ecj-13110	17	11	absorption	absorption	NOUN
ecj-13110	17	12	of	of	ADP
ecj-13110	17	13	intranasal	intranasal	ADJ
ecj-13110	17	14	naloxone	naloxone	NOUN
ecj-13110	17	15	may	may	AUX
ecj-13110	17	16	help	help	VERB
ecj-13110	17	17	reduce	reduce	VERB
ecj-13110	17	18	withdrawal	withdrawal	NOUN
ecj-13110	17	19	symptoms	symptom	NOUN
ecj-13110	17	20	,	,	PUNCT
ecj-13110	17	21	supporting	support	VERB
ecj-13110	17	22	gradual	gradual	ADJ
ecj-13110	17	23	dosing	dosing	ADJ
ecj-13110	17	24	strategies	strategy	NOUN
ecj-13110	17	25	.	.	PUNCT
ecj-13110	18	1	these	these	DET
ecj-13110	18	2	findings	finding	NOUN
ecj-13110	18	3	emphasize	emphasize	VERB
ecj-13110	18	4	the	the	DET
ecj-13110	18	5	need	need	NOUN
ecj-13110	18	6	for	for	ADP
ecj-13110	18	7	further	further	ADJ
ecj-13110	18	8	research	research	NOUN
ecj-13110	18	9	on	on	ADP
ecj-13110	18	10	optimizing	optimize	VERB
ecj-13110	18	11	naloxone	naloxone	NOUN
ecj-13110	18	12	dosing	dose	VERB
ecj-13110	18	13	for	for	ADP
ecj-13110	18	14	synthetic	synthetic	ADJ
ecj-13110	18	15	opioid	opioid	ADJ
ecj-13110	18	16	emergencies	emergency	NOUN
ecj-13110	18	17	.	.	PUNCT
ecj-13110	19	1	this	this	DET
ecj-13110	19	2	review	review	NOUN
ecj-13110	19	3	highlights	highlight	VERB
ecj-13110	19	4	intravenous	intravenous	ADJ
ecj-13110	19	5	naloxone	naloxone	NOUN
ecj-13110	19	6	as	as	ADP
ecj-13110	19	7	the	the	DET
ecj-13110	19	8	most	most	ADV
ecj-13110	19	9	effective	effective	ADJ
ecj-13110	19	10	route	route	NOUN
ecj-13110	19	11	for	for	ADP
ecj-13110	19	12	opioid	opioid	ADJ
ecj-13110	19	13	overdose	overdose	ADJ
ecj-13110	19	14	treatment	treatment	NOUN
ecj-13110	19	15	,	,	PUNCT
ecj-13110	19	16	with	with	ADP
ecj-13110	19	17	intramuscular	intramuscular	ADJ
ecj-13110	19	18	and	and	CCONJ
ecj-13110	19	19	intranasal	intranasal	ADJ
ecj-13110	19	20	routes	route	NOUN
ecj-13110	19	21	offering	offer	VERB
ecj-13110	19	22	practical	practical	ADJ
ecj-13110	19	23	alternatives	alternative	NOUN
ecj-13110	19	24	in	in	ADP
ecj-13110	19	25	prehospital	prehospital	ADJ
ecj-13110	19	26	settings	setting	NOUN
ecj-13110	19	27	.	.	PUNCT
ecj-13110	20	1	intranasal	intranasal	ADJ
ecj-13110	20	2	naloxone	naloxone	NOUN
ecj-13110	20	3	,	,	PUNCT
ecj-13110	20	4	despite	despite	SCONJ
ecj-13110	20	5	its	its	PRON
ecj-13110	20	6	lower	low	ADJ
ecj-13110	20	7	bioavailability	bioavailability	NOUN
ecj-13110	20	8	,	,	PUNCT
ecj-13110	20	9	provides	provide	VERB
ecj-13110	20	10	a	a	DET
ecj-13110	20	11	non	non	ADJ
ecj-13110	20	12	-	-	ADJ
ecj-13110	20	13	invasive	invasive	ADJ
ecj-13110	20	14	option	option	NOUN
ecj-13110	20	15	suitable	suitable	ADJ
ecj-13110	20	16	for	for	ADP
ecj-13110	20	17	lay	lie	VERB
ecj-13110	20	18	responders	responder	NOUN
ecj-13110	20	19	.	.	PUNCT
ecj-13110	21	1	gradual	gradual	ADJ
ecj-13110	21	2	dose	dose	NOUN
ecj-13110	21	3	escalation	escalation	NOUN
ecj-13110	21	4	is	be	AUX
ecj-13110	21	5	recommended	recommend	VERB
ecj-13110	21	6	to	to	PART
ecj-13110	21	7	minimize	minimize	VERB
ecj-13110	21	8	withdrawal	withdrawal	NOUN
ecj-13110	21	9	symptoms	symptom	NOUN
ecj-13110	21	10	.	.	PUNCT
ecj-13110	22	1	the	the	DET
ecj-13110	22	2	increasing	increase	VERB
ecj-13110	22	3	prevalence	prevalence	NOUN
ecj-13110	22	4	of	of	ADP
ecj-13110	22	5	synthetic	synthetic	ADJ
ecj-13110	22	6	opioids	opioid	NOUN
ecj-13110	22	7	underscores	underscore	VERB
ecj-13110	22	8	the	the	DET
ecj-13110	22	9	need	need	NOUN
ecj-13110	22	10	for	for	ADP
ecj-13110	22	11	updated	update	VERB
ecj-13110	22	12	clinical	clinical	ADJ
ecj-13110	22	13	guidelines	guideline	NOUN
ecj-13110	22	14	on	on	ADP
ecj-13110	22	15	naloxone	naloxone	ADJ
ecj-13110	22	16	dosing	dosing	NOUN
ecj-13110	22	17	and	and	CCONJ
ecj-13110	22	18	administration	administration	NOUN
ecj-13110	22	19	routes	route	NOUN
ecj-13110	22	20	.	.	PUNCT
ecj-13110	23	1	emergency	emergency	NOUN
ecj-13110	23	2	care	care	PROPN
ecj-13110	23	3	journal	journal	PROPN
ecj-13110	23	4	2025	2025	NUM
ecj-13110	23	5	;	;	PUNCT
ecj-13110	23	6	volume	volume	NOUN
ecj-13110	23	7	21:13110	21:13110	NUM
ecj-13110	24	1	[	[	X
ecj-13110	24	2	emergency	emergency	NOUN
ecj-13110	24	3	care	care	NOUN
ecj-13110	24	4	journal	journal	NOUN
ecj-13110	24	5	2025	2025	NUM
ecj-13110	24	6	;	;	PUNCT
ecj-13110	24	7	21:13110	21:13110	NUM
ecj-13110	24	8	]	]	X
ecj-13110	25	1	[	[	X
ecj-13110	25	2	page	page	NOUN
ecj-13110	25	3	41	41	NUM
ecj-13110	25	4	]	]	SYM
ecj-13110	25	5	efficacy	efficacy	NOUN
ecj-13110	25	6	of	of	ADP
ecj-13110	25	7	intranasal	intranasal	ADJ
ecj-13110	25	8	naloxone	naloxone	NOUN
ecj-13110	25	9	compared	compare	VERB
ecj-13110	25	10	to	to	ADP
ecj-13110	25	11	other	other	ADJ
ecj-13110	25	12	administration	administration	NOUN
ecj-13110	25	13	routes	route	NOUN
ecj-13110	25	14	in	in	ADP
ecj-13110	25	15	prehospital	prehospital	ADJ
ecj-13110	25	16	opioid	opioid	NOUN
ecj-13110	25	17	overdose	overdose	ADJ
ecj-13110	25	18	management	management	NOUN
ecj-13110	25	19	and	and	CCONJ
ecj-13110	25	20	beyond	beyond	ADP
ecj-13110	25	21	:	:	PUNCT
ecj-13110	25	22	a	a	DET
ecj-13110	25	23	narrative	narrative	NOUN
ecj-13110	25	24	review	review	NOUN
ecj-13110	25	25	luigi	luigi	PROPN
ecj-13110	25	26	venuso,1	venuso,1	VERB
ecj-13110	25	27	francesco	francesco	PROPN
ecj-13110	25	28	ricciardi,2	ricciardi,2	PROPN
ecj-13110	25	29	antonio	antonio	PROPN
ecj-13110	25	30	del	del	PROPN
ecj-13110	25	31	prete,1	prete,1	PROPN
ecj-13110	25	32	michele	michele	PROPN
ecj-13110	25	33	virgolesi,3	virgolesi,3	VERB
ecj-13110	25	34	gianluca	gianluca	PROPN
ecj-13110	25	35	pucciarelli,4	pucciarelli,4	PROPN
ecj-13110	25	36	luigi	luigi	PROPN
ecj-13110	25	37	langella,1	langella,1	PROPN
ecj-13110	25	38	teresa	teresa	PROPN
ecj-13110	25	39	rea3	rea3	PROPN
ecj-13110	25	40	1department	1department	NUM
ecj-13110	25	41	of	of	ADP
ecj-13110	25	42	emergency	emergency	NOUN
ecj-13110	25	43	and	and	CCONJ
ecj-13110	25	44	critical	critical	ADJ
ecj-13110	25	45	care	care	NOUN
ecj-13110	25	46	,	,	PUNCT
ecj-13110	25	47	a.s.l	a.s.l	NOUN
ecj-13110	25	48	.	.	PUNCT
ecj-13110	26	1	napoli	napoli	PROPN
ecj-13110	26	2	2	2	NUM
ecj-13110	26	3	nord	nord	NOUN
ecj-13110	26	4	,	,	PUNCT
ecj-13110	26	5	frattamaggiore	frattamaggiore	NOUN
ecj-13110	26	6	;	;	PUNCT
ecj-13110	26	7	2department	2department	NUM
ecj-13110	26	8	of	of	ADP
ecj-13110	26	9	emergency	emergency	NOUN
ecj-13110	26	10	and	and	CCONJ
ecj-13110	26	11	critical	critical	ADJ
ecj-13110	26	12	care	care	NOUN
ecj-13110	26	13	,	,	PUNCT
ecj-13110	26	14	a.o.r.n	a.o.r.n	PROPN
ecj-13110	26	15	antonio	antonio	PROPN
ecj-13110	26	16	cardarelli	cardarelli	PROPN
ecj-13110	26	17	,	,	PUNCT
ecj-13110	26	18	naples	naples	PROPN
ecj-13110	26	19	;	;	PUNCT
ecj-13110	27	1	3department	3department	NUM
ecj-13110	27	2	of	of	ADP
ecj-13110	27	3	public	public	ADJ
ecj-13110	27	4	health	health	NOUN
ecj-13110	27	5	,	,	PUNCT
ecj-13110	27	6	university	university	PROPN
ecj-13110	27	7	federico	federico	PROPN
ecj-13110	27	8	ii	ii	PROPN
ecj-13110	27	9	,	,	PUNCT
ecj-13110	27	10	naples	naples	PROPN
ecj-13110	27	11	;	;	PUNCT
ecj-13110	27	12	4department	4department	NUM
ecj-13110	27	13	of	of	ADP
ecj-13110	27	14	biomedicine	biomedicine	NOUN
ecj-13110	27	15	and	and	CCONJ
ecj-13110	27	16	prevention	prevention	NOUN
ecj-13110	27	17	,	,	PUNCT
ecj-13110	27	18	university	university	PROPN
ecj-13110	27	19	of	of	ADP
ecj-13110	27	20	rome	rome	PROPN
ecj-13110	27	21	tor	tor	PROPN
ecj-13110	27	22	vergata	vergata	PROPN
ecj-13110	27	23	,	,	PUNCT
ecj-13110	27	24	italy	italy	PROPN
ecj-13110	27	25	correspondence	correspondence	NOUN
ecj-13110	27	26	:	:	PUNCT
ecj-13110	28	1	michele	michele	PROPN
ecj-13110	28	2	virgolesi	virgolesi	PROPN
ecj-13110	28	3	,	,	PUNCT
ecj-13110	28	4	department	department	NOUN
ecj-13110	28	5	of	of	ADP
ecj-13110	28	6	public	public	ADJ
ecj-13110	28	7	health	health	NOUN
ecj-13110	28	8	,	,	PUNCT
ecj-13110	28	9	university	university	PROPN
ecj-13110	28	10	federico	federico	PROPN
ecj-13110	28	11	ii	ii	PROPN
ecj-13110	28	12	,	,	PUNCT
ecj-13110	28	13	naples	naples	PROPN
ecj-13110	28	14	,	,	PUNCT
ecj-13110	28	15	italy	italy	PROPN
ecj-13110	28	16	.	.	PUNCT
ecj-13110	29	1	e	e	X
ecj-13110	29	2	-	-	NOUN
ecj-13110	29	3	mail	mail	NOUN
ecj-13110	29	4	:	:	PUNCT
ecj-13110	29	5	michele.virgolesi@unina.it	michele.virgolesi@unina.it	PROPN
ecj-13110	29	6	key	key	ADJ
ecj-13110	29	7	words	word	NOUN
ecj-13110	29	8	:	:	PUNCT
ecj-13110	29	9	opioid	opioid	ADJ
ecj-13110	29	10	overdose	overdose	ADV
ecj-13110	29	11	;	;	PUNCT
ecj-13110	29	12	naloxone	naloxone	NOUN
ecj-13110	29	13	;	;	PUNCT
ecj-13110	29	14	prehospital	prehospital	ADJ
ecj-13110	29	15	emergency	emergency	NOUN
ecj-13110	29	16	care	care	NOUN
ecj-13110	29	17	;	;	PUNCT
ecj-13110	29	18	emergency	emergency	NOUN
ecj-13110	29	19	medical	medical	ADJ
ecj-13110	29	20	services	service	NOUN
ecj-13110	29	21	.	.	PUNCT
ecj-13110	30	1	contributions	contribution	NOUN
ecj-13110	30	2	:	:	PUNCT
ecj-13110	30	3	lv	lv	PROPN
ecj-13110	30	4	,	,	PUNCT
ecj-13110	30	5	adp	adp	PROPN
ecj-13110	30	6	,	,	PUNCT
ecj-13110	30	7	mv	mv	PROPN
ecj-13110	30	8	,	,	PUNCT
ecj-13110	30	9	contributed	contribute	VERB
ecj-13110	30	10	to	to	ADP
ecj-13110	30	11	the	the	DET
ecj-13110	30	12	conception	conception	NOUN
ecj-13110	30	13	and	and	CCONJ
ecj-13110	30	14	design	design	NOUN
ecj-13110	30	15	of	of	ADP
ecj-13110	30	16	the	the	DET
ecj-13110	30	17	study	study	NOUN
ecj-13110	30	18	;	;	PUNCT
ecj-13110	30	19	lv	lv	PROPN
ecj-13110	30	20	,	,	PUNCT
ecj-13110	30	21	fr	fr	PROPN
ecj-13110	30	22	,	,	PUNCT
ecj-13110	30	23	drafted	draft	VERB
ecj-13110	30	24	the	the	DET
ecj-13110	30	25	article	article	NOUN
ecj-13110	30	26	;	;	PUNCT
ecj-13110	30	27	tr	tr	VERB
ecj-13110	30	28	,	,	PUNCT
ecj-13110	30	29	gp	gp	NOUN
ecj-13110	30	30	,	,	PUNCT
ecj-13110	30	31	analyzed	analyze	VERB
ecj-13110	30	32	and	and	CCONJ
ecj-13110	30	33	interpreted	interpret	VERB
ecj-13110	30	34	the	the	DET
ecj-13110	30	35	data	datum	NOUN
ecj-13110	30	36	;	;	PUNCT
ecj-13110	30	37	ll	ll	AUX
ecj-13110	30	38	,	,	PUNCT
ecj-13110	30	39	critically	critically	ADV
ecj-13110	30	40	revised	revise	VERB
ecj-13110	30	41	the	the	DET
ecj-13110	30	42	manuscript	manuscript	NOUN
ecj-13110	30	43	for	for	ADP
ecj-13110	30	44	important	important	ADJ
ecj-13110	30	45	intellectual	intellectual	ADJ
ecj-13110	30	46	content	content	NOUN
ecj-13110	30	47	.	.	PUNCT
ecj-13110	31	1	all	all	DET
ecj-13110	31	2	authors	author	NOUN
ecj-13110	31	3	provided	provide	VERB
ecj-13110	31	4	final	final	ADJ
ecj-13110	31	5	approval	approval	NOUN
ecj-13110	31	6	of	of	ADP
ecj-13110	31	7	the	the	DET
ecj-13110	31	8	version	version	NOUN
ecj-13110	31	9	to	to	PART
ecj-13110	31	10	be	be	AUX
ecj-13110	31	11	published	publish	VERB
ecj-13110	31	12	and	and	CCONJ
ecj-13110	31	13	agreed	agree	VERB
ecj-13110	31	14	to	to	PART
ecj-13110	31	15	be	be	AUX
ecj-13110	31	16	accountable	accountable	ADJ
ecj-13110	31	17	for	for	ADP
ecj-13110	31	18	all	all	DET
ecj-13110	31	19	aspects	aspect	NOUN
ecj-13110	31	20	of	of	ADP
ecj-13110	31	21	the	the	DET
ecj-13110	31	22	work	work	NOUN
ecj-13110	31	23	.	.	PUNCT
ecj-13110	32	1	conflict	conflict	NOUN
ecj-13110	32	2	of	of	ADP
ecj-13110	32	3	interest	interest	NOUN
ecj-13110	32	4	:	:	PUNCT
ecj-13110	32	5	the	the	DET
ecj-13110	32	6	authors	author	NOUN
ecj-13110	32	7	report	report	VERB
ecj-13110	32	8	no	no	DET
ecj-13110	32	9	conflict	conflict	NOUN
ecj-13110	32	10	of	of	ADP
ecj-13110	32	11	interest	interest	NOUN
ecj-13110	32	12	.	.	PUNCT
ecj-13110	33	1	ethics	ethic	NOUN
ecj-13110	33	2	approval	approval	NOUN
ecj-13110	33	3	and	and	CCONJ
ecj-13110	33	4	consent	consent	NOUN
ecj-13110	33	5	to	to	PART
ecj-13110	33	6	participate	participate	VERB
ecj-13110	33	7	:	:	PUNCT
ecj-13110	33	8	not	not	PART
ecj-13110	33	9	applicable	applicable	ADJ
ecj-13110	33	10	.	.	PUNCT
ecj-13110	34	1	consent	consent	NOUN
ecj-13110	34	2	for	for	ADP
ecj-13110	34	3	publication	publication	NOUN
ecj-13110	34	4	:	:	PUNCT
ecj-13110	34	5	not	not	PART
ecj-13110	34	6	applicable	applicable	ADJ
ecj-13110	34	7	.	.	PUNCT
ecj-13110	35	1	availability	availability	NOUN
ecj-13110	35	2	of	of	ADP
ecj-13110	35	3	data	datum	NOUN
ecj-13110	35	4	and	and	CCONJ
ecj-13110	35	5	materials	material	NOUN
ecj-13110	35	6	:	:	PUNCT
ecj-13110	35	7	all	all	DET
ecj-13110	35	8	data	datum	NOUN
ecj-13110	35	9	generated	generate	VERB
ecj-13110	35	10	or	or	CCONJ
ecj-13110	35	11	analyzed	analyze	VERB
ecj-13110	35	12	during	during	ADP
ecj-13110	35	13	this	this	DET
ecj-13110	35	14	study	study	NOUN
ecj-13110	35	15	are	be	AUX
ecj-13110	35	16	included	include	VERB
ecj-13110	35	17	in	in	ADP
ecj-13110	35	18	this	this	DET
ecj-13110	35	19	published	publish	VERB
ecj-13110	35	20	article	article	NOUN
ecj-13110	35	21	.	.	PUNCT
ecj-13110	36	1	funding	funding	NOUN
ecj-13110	36	2	:	:	PUNCT
ecj-13110	36	3	this	this	DET
ecj-13110	36	4	research	research	NOUN
ecj-13110	36	5	did	do	AUX
ecj-13110	36	6	not	not	PART
ecj-13110	36	7	receive	receive	VERB
ecj-13110	36	8	any	any	DET
ecj-13110	36	9	specific	specific	ADJ
ecj-13110	36	10	grant	grant	NOUN
ecj-13110	36	11	from	from	ADP
ecj-13110	36	12	funding	fund	VERB
ecj-13110	36	13	agencies	agency	NOUN
ecj-13110	36	14	in	in	ADP
ecj-13110	36	15	the	the	DET
ecj-13110	36	16	public	public	ADJ
ecj-13110	36	17	,	,	PUNCT
ecj-13110	36	18	commercial	commercial	ADJ
ecj-13110	36	19	,	,	PUNCT
ecj-13110	36	20	or	or	CCONJ
ecj-13110	36	21	not	not	PART
ecj-13110	36	22	-	-	PUNCT
ecj-13110	36	23	for	for	ADP
ecj-13110	36	24	-	-	PUNCT
ecj-13110	36	25	profit	profit	NOUN
ecj-13110	36	26	sectors	sector	NOUN
ecj-13110	36	27	.	.	PUNCT
ecj-13110	37	1	received	receive	VERB
ecj-13110	37	2	:	:	PUNCT
ecj-13110	37	3	15	15	NUM
ecj-13110	37	4	september	september	PROPN
ecj-13110	37	5	2024	2024	NUM
ecj-13110	37	6	.	.	PUNCT
ecj-13110	38	1	accepted	accept	VERB
ecj-13110	38	2	:	:	PUNCT
ecj-13110	38	3	21	21	NUM
ecj-13110	38	4	november	november	PROPN
ecj-13110	38	5	2024	2024	NUM
ecj-13110	38	6	.	.	PUNCT
ecj-13110	39	1	early	early	ADJ
ecj-13110	39	2	view	view	NOUN
ecj-13110	39	3	:	:	PUNCT
ecj-13110	39	4	22	22	NUM
ecj-13110	39	5	january	january	NOUN
ecj-13110	39	6	2025	2025	NUM
ecj-13110	39	7	.	.	PUNCT
ecj-13110	40	1	this	this	DET
ecj-13110	40	2	work	work	NOUN
ecj-13110	40	3	is	be	AUX
ecj-13110	40	4	licensed	license	VERB
ecj-13110	40	5	under	under	ADP
ecj-13110	40	6	a	a	DET
ecj-13110	40	7	creative	creative	ADJ
ecj-13110	40	8	commons	common	NOUN
ecj-13110	40	9	attribution	attribution	NOUN
ecj-13110	40	10	4.0	4.0	NUM
ecj-13110	40	11	license	license	NOUN
ecj-13110	40	12	(	(	PUNCT
ecj-13110	40	13	by	by	ADP
ecj-13110	40	14	-	-	PUNCT
ecj-13110	40	15	nc	nc	PROPN
ecj-13110	40	16	4.0	4.0	NUM
ecj-13110	40	17	)	)	PUNCT
ecj-13110	40	18	.	.	PUNCT
ecj-13110	41	1	©	©	PROPN
ecj-13110	41	2	copyright	copyright	NOUN
ecj-13110	41	3	:	:	PUNCT
ecj-13110	41	4	the	the	DET
ecj-13110	41	5	author(s	author(s	PROPN
ecj-13110	41	6	)	)	PUNCT
ecj-13110	41	7	,	,	PUNCT
ecj-13110	41	8	2025	2025	NUM
ecj-13110	41	9	licensee	licensee	NOUN
ecj-13110	41	10	pagepress	pagepress	NOUN
ecj-13110	41	11	,	,	PUNCT
ecj-13110	41	12	italy	italy	PROPN
ecj-13110	41	13	emergency	emergency	PROPN
ecj-13110	41	14	care	care	PROPN
ecj-13110	41	15	journal	journal	PROPN
ecj-13110	41	16	2025	2025	NUM
ecj-13110	41	17	;	;	PUNCT
ecj-13110	41	18	21:13110	21:13110	NUM
ecj-13110	41	19	doi:10.4081	doi:10.4081	NOUN
ecj-13110	41	20	/	/	SYM
ecj-13110	41	21	ecj.2025.13110	ecj.2025.13110	PROPN
ecj-13110	41	22	publisher	publisher	NOUN
ecj-13110	41	23	's	's	PART
ecj-13110	41	24	note	note	NOUN
ecj-13110	41	25	:	:	PUNCT
ecj-13110	41	26	all	all	DET
ecj-13110	41	27	claims	claim	NOUN
ecj-13110	41	28	expressed	express	VERB
ecj-13110	41	29	in	in	ADP
ecj-13110	41	30	this	this	DET
ecj-13110	41	31	article	article	NOUN
ecj-13110	41	32	are	be	AUX
ecj-13110	41	33	solely	solely	ADV
ecj-13110	41	34	those	those	PRON
ecj-13110	41	35	of	of	ADP
ecj-13110	41	36	the	the	DET
ecj-13110	41	37	authors	author	NOUN
ecj-13110	41	38	and	and	CCONJ
ecj-13110	41	39	do	do	AUX
ecj-13110	41	40	not	not	PART
ecj-13110	41	41	necessarily	necessarily	ADV
ecj-13110	41	42	represent	represent	VERB
ecj-13110	41	43	those	those	PRON
ecj-13110	41	44	of	of	ADP
ecj-13110	41	45	their	their	PRON
ecj-13110	41	46	affiliated	affiliated	ADJ
ecj-13110	41	47	organizations	organization	NOUN
ecj-13110	41	48	,	,	PUNCT
ecj-13110	41	49	or	or	CCONJ
ecj-13110	41	50	those	those	PRON
ecj-13110	41	51	of	of	ADP
ecj-13110	41	52	the	the	DET
ecj-13110	41	53	publisher	publisher	NOUN
ecj-13110	41	54	,	,	PUNCT
ecj-13110	41	55	the	the	DET
ecj-13110	41	56	editors	editor	NOUN
ecj-13110	41	57	and	and	CCONJ
ecj-13110	41	58	the	the	DET
ecj-13110	41	59	reviewers	reviewer	NOUN
ecj-13110	41	60	.	.	PUNCT
ecj-13110	42	1	any	any	DET
ecj-13110	42	2	product	product	NOUN
ecj-13110	42	3	that	that	PRON
ecj-13110	42	4	may	may	AUX
ecj-13110	42	5	be	be	AUX
ecj-13110	42	6	evaluated	evaluate	VERB
ecj-13110	42	7	in	in	ADP
ecj-13110	42	8	this	this	DET
ecj-13110	42	9	article	article	NOUN
ecj-13110	42	10	or	or	CCONJ
ecj-13110	42	11	claim	claim	NOUN
ecj-13110	42	12	that	that	PRON
ecj-13110	42	13	may	may	AUX
ecj-13110	42	14	be	be	AUX
ecj-13110	42	15	made	make	VERB
ecj-13110	42	16	by	by	ADP
ecj-13110	42	17	its	its	PRON
ecj-13110	42	18	manufacturer	manufacturer	NOUN
ecj-13110	42	19	is	be	AUX
ecj-13110	42	20	not	not	PART
ecj-13110	42	21	guaranteed	guarantee	VERB
ecj-13110	42	22	or	or	CCONJ
ecj-13110	42	23	endorsed	endorse	VERB
ecj-13110	42	24	by	by	ADP
ecj-13110	42	25	the	the	DET
ecj-13110	42	26	publisher	publisher	NOUN
ecj-13110	42	27	.	.	PUNCT
ecj-13110	43	1	introduction	introduction	NOUN
ecj-13110	43	2	the	the	DET
ecj-13110	43	3	consumption	consumption	NOUN
ecj-13110	43	4	of	of	ADP
ecj-13110	43	5	illicit	illicit	ADJ
ecj-13110	43	6	drugs	drug	NOUN
ecj-13110	43	7	can	can	AUX
ecj-13110	43	8	be	be	AUX
ecj-13110	43	9	considered	consider	VERB
ecj-13110	43	10	a	a	DET
ecj-13110	43	11	global	global	ADJ
ecj-13110	43	12	scourge	scourge	NOUN
ecj-13110	43	13	.	.	PUNCT
ecj-13110	44	1	according	accord	VERB
ecj-13110	44	2	to	to	ADP
ecj-13110	44	3	the	the	DET
ecj-13110	44	4	world	world	NOUN
ecj-13110	44	5	drug	drug	NOUN
ecj-13110	44	6	report,1	report,1	NOUN
ecj-13110	44	7	approximately	approximately	ADV
ecj-13110	44	8	61	61	NUM
ecj-13110	44	9	million	million	NUM
ecj-13110	44	10	people	people	NOUN
ecj-13110	44	11	worldwide	worldwide	ADV
ecj-13110	44	12	used	use	VERB
ecj-13110	44	13	opioids	opioid	NOUN
ecj-13110	44	14	for	for	ADP
ecj-13110	44	15	non	non	ADJ
ecj-13110	44	16	-	-	ADJ
ecj-13110	44	17	medical	medical	ADJ
ecj-13110	44	18	purposes	purpose	NOUN
ecj-13110	44	19	in	in	ADP
ecj-13110	44	20	2020	2020	NUM
ecj-13110	44	21	,	,	PUNCT
ecj-13110	44	22	with	with	ADP
ecj-13110	44	23	31	31	NUM
ecj-13110	44	24	million	million	NUM
ecj-13110	44	25	being	be	AUX
ecj-13110	44	26	regular	regular	ADJ
ecj-13110	44	27	opioid	opioid	ADJ
ecj-13110	44	28	users	user	NOUN
ecj-13110	44	29	(	(	PUNCT
ecj-13110	44	30	mainly	mainly	ADV
ecj-13110	44	31	heroin	heroin	NOUN
ecj-13110	44	32	)	)	PUNCT
ecj-13110	44	33	.	.	PUNCT
ecj-13110	45	1	while	while	SCONJ
ecj-13110	45	2	opioid	opioid	ADJ
ecj-13110	45	3	use	use	NOUN
ecj-13110	45	4	remained	remain	VERB
ecj-13110	45	5	stable	stable	ADJ
ecj-13110	45	6	between	between	ADP
ecj-13110	45	7	2019	2019	NUM
ecj-13110	45	8	and	and	CCONJ
ecj-13110	45	9	2020	2020	NUM
ecj-13110	45	10	,	,	PUNCT
ecj-13110	45	11	there	there	PRON
ecj-13110	45	12	is	be	VERB
ecj-13110	45	13	concern	concern	NOUN
ecj-13110	45	14	about	about	ADP
ecj-13110	45	15	the	the	DET
ecj-13110	45	16	upward	upward	ADJ
ecj-13110	45	17	trend	trend	NOUN
ecj-13110	45	18	observed	observe	VERB
ecj-13110	45	19	between	between	ADP
ecj-13110	45	20	2010	2010	NUM
ecj-13110	45	21	and	and	CCONJ
ecj-13110	45	22	2020	2020	NUM
ecj-13110	45	23	,	,	PUNCT
ecj-13110	45	24	during	during	ADP
ecj-13110	45	25	which	which	PRON
ecj-13110	45	26	the	the	DET
ecj-13110	45	27	number	number	NOUN
ecj-13110	45	28	of	of	ADP
ecj-13110	45	29	opioid	opioid	NOUN
ecj-13110	45	30	users	user	NOUN
ecj-13110	45	31	doubled	double	VERB
ecj-13110	45	32	.	.	PUNCT
ecj-13110	46	1	in	in	ADP
ecj-13110	46	2	2019	2019	NUM
ecj-13110	46	3	,	,	PUNCT
ecj-13110	46	4	opioid	opioid	ADJ
ecj-13110	46	5	use	use	VERB
ecj-13110	46	6	disorders	disorder	NOUN
ecj-13110	46	7	accounted	account	VERB
ecj-13110	46	8	for	for	ADP
ecj-13110	46	9	approximately	approximately	ADV
ecj-13110	46	10	12.9	12.9	NUM
ecj-13110	46	11	million	million	NUM
ecj-13110	46	12	healthy	healthy	ADJ
ecj-13110	46	13	years	year	NOUN
ecj-13110	46	14	of	of	ADP
ecj-13110	46	15	life	life	NOUN
ecj-13110	46	16	lost	lose	VERB
ecj-13110	46	17	due	due	ADJ
ecj-13110	46	18	to	to	ADP
ecj-13110	46	19	disability	disability	NOUN
ecj-13110	46	20	and	and	CCONJ
ecj-13110	46	21	premature	premature	ADJ
ecj-13110	46	22	death	death	NOUN
ecj-13110	46	23	.	.	PUNCT
ecj-13110	47	1	intravenous	intravenous	ADJ
ecj-13110	47	2	drug	drug	NOUN
ecj-13110	47	3	use	use	NOUN
ecj-13110	47	4	remains	remain	VERB
ecj-13110	47	5	particularly	particularly	ADV
ecj-13110	47	6	widespread	widespread	ADJ
ecj-13110	47	7	in	in	ADP
ecj-13110	47	8	eastern	eastern	PROPN
ecj-13110	47	9	europe	europe	PROPN
ecj-13110	47	10	and	and	CCONJ
ecj-13110	47	11	,	,	PUNCT
ecj-13110	47	12	to	to	ADP
ecj-13110	47	13	a	a	DET
ecj-13110	47	14	lesser	less	ADJ
ecj-13110	47	15	extent	extent	NOUN
ecj-13110	47	16	,	,	PUNCT
ecj-13110	47	17	in	in	ADP
ecj-13110	47	18	central	central	ADJ
ecj-13110	47	19	europe.2	europe.2	PROPN
ecj-13110	47	20	in	in	ADP
ecj-13110	47	21	italy	italy	PROPN
ecj-13110	47	22	,	,	PUNCT
ecj-13110	47	23	according	accord	VERB
ecj-13110	47	24	to	to	ADP
ecj-13110	47	25	the	the	DET
ecj-13110	47	26	2022	2022	NUM
ecj-13110	47	27	report	report	NOUN
ecj-13110	47	28	to	to	ADP
ecj-13110	47	29	parliament,3	parliament,3	NOUN
ecj-13110	47	30	wastewater	wastewater	NOUN
ecj-13110	47	31	analyses	analysis	NOUN
ecj-13110	47	32	revealed	reveal	VERB
ecj-13110	47	33	that	that	SCONJ
ecj-13110	47	34	heroin	heroin	NOUN
ecj-13110	47	35	use	use	NOUN
ecj-13110	47	36	follows	follow	VERB
ecj-13110	47	37	that	that	PRON
ecj-13110	47	38	of	of	ADP
ecj-13110	47	39	cannabis	cannabis	NOUN
ecj-13110	47	40	and	and	CCONJ
ecj-13110	47	41	cocaine	cocaine	NOUN
ecj-13110	47	42	,	,	PUNCT
ecj-13110	47	43	with	with	ADP
ecj-13110	47	44	an	an	DET
ecj-13110	47	45	average	average	NOUN
ecj-13110	47	46	of	of	ADP
ecj-13110	47	47	3.2	3.2	NUM
ecj-13110	47	48	daily	daily	ADJ
ecj-13110	47	49	doses	dose	NOUN
ecj-13110	47	50	per	per	ADP
ecj-13110	47	51	1000	1000	NUM
ecj-13110	47	52	inhabitants	inhabitant	NOUN
ecj-13110	47	53	.	.	PUNCT
ecj-13110	48	1	heroin	heroin	NOUN
ecj-13110	48	2	consumption	consumption	NOUN
ecj-13110	48	3	is	be	AUX
ecj-13110	48	4	particularly	particularly	ADV
ecj-13110	48	5	high	high	ADJ
ecj-13110	48	6	in	in	ADP
ecj-13110	48	7	the	the	DET
ecj-13110	48	8	city	city	NOUN
ecj-13110	48	9	of	of	ADP
ecj-13110	48	10	perugia	perugia	PROPN
ecj-13110	48	11	,	,	PUNCT
ecj-13110	48	12	with	with	ADP
ecj-13110	48	13	12	12	NUM
ecj-13110	48	14	doses	dose	NOUN
ecj-13110	48	15	per	per	ADP
ecj-13110	48	16	1000	1000	NUM
ecj-13110	48	17	inhabitants	inhabitant	NOUN
ecj-13110	48	18	per	per	ADP
ecj-13110	48	19	day	day	NOUN
ecj-13110	48	20	,	,	PUNCT
ecj-13110	48	21	and	and	CCONJ
ecj-13110	48	22	ranges	range	VERB
ecj-13110	48	23	from	from	ADP
ecj-13110	48	24	6	6	NUM
ecj-13110	48	25	to	to	PART
ecj-13110	48	26	8	8	NUM
ecj-13110	48	27	doses	dose	NOUN
ecj-13110	48	28	per	per	ADP
ecj-13110	48	29	day	day	NOUN
ecj-13110	48	30	in	in	ADP
ecj-13110	48	31	cities	city	NOUN
ecj-13110	48	32	such	such	ADJ
ecj-13110	48	33	as	as	ADP
ecj-13110	48	34	bologna	bologna	NOUN
ecj-13110	48	35	,	,	PUNCT
ecj-13110	48	36	fidenza	fidenza	ADJ
ecj-13110	48	37	,	,	PUNCT
ecj-13110	48	38	ancona	ancona	PROPN
ecj-13110	48	39	,	,	PUNCT
ecj-13110	48	40	terni	terni	PROPN
ecj-13110	48	41	,	,	PUNCT
ecj-13110	48	42	trieste	trieste	NOUN
ecj-13110	48	43	,	,	PUNCT
ecj-13110	48	44	and	and	CCONJ
ecj-13110	48	45	campobasso.4,5	campobasso.4,5	NOUN
ecj-13110	48	46	despite	despite	SCONJ
ecj-13110	48	47	the	the	DET
ecj-13110	48	48	critical	critical	ADJ
ecj-13110	48	49	importance	importance	NOUN
ecj-13110	48	50	of	of	ADP
ecj-13110	48	51	timely	timely	ADJ
ecj-13110	48	52	intervention	intervention	NOUN
ecj-13110	48	53	in	in	ADP
ecj-13110	48	54	opioid	opioid	ADJ
ecj-13110	48	55	overdose	overdose	ADJ
ecj-13110	48	56	cases	case	NOUN
ecj-13110	48	57	,	,	PUNCT
ecj-13110	48	58	comprehensive	comprehensive	ADJ
ecj-13110	48	59	and	and	CCONJ
ecj-13110	48	60	up	up	ADP
ecj-13110	48	61	-	-	PUNCT
ecj-13110	48	62	to	to	ADP
ecj-13110	48	63	-	-	PUNCT
ecj-13110	48	64	date	date	NOUN
ecj-13110	48	65	guidelines	guideline	NOUN
ecj-13110	48	66	on	on	ADP
ecj-13110	48	67	prehospital	prehospital	ADJ
ecj-13110	48	68	management	management	NOUN
ecj-13110	48	69	remain	remain	VERB
ecj-13110	48	70	scarce	scarce	ADJ
ecj-13110	48	71	.	.	PUNCT
ecj-13110	49	1	a	a	DET
ecj-13110	49	2	preliminary	preliminary	ADJ
ecj-13110	49	3	review	review	NOUN
ecj-13110	49	4	of	of	ADP
ecj-13110	49	5	the	the	DET
ecj-13110	49	6	literature	literature	NOUN
ecj-13110	49	7	identified	identify	VERB
ecj-13110	49	8	three	three	NUM
ecj-13110	49	9	key	key	ADJ
ecj-13110	49	10	documents	document	NOUN
ecj-13110	49	11	addressing	address	VERB
ecj-13110	49	12	this	this	DET
ecj-13110	49	13	topic	topic	NOUN
ecj-13110	49	14	.	.	PUNCT
ecj-13110	50	1	the	the	DET
ecj-13110	50	2	2014	2014	NUM
ecj-13110	50	3	who	who	PRON
ecj-13110	50	4	recommendations	recommendation	NOUN
ecj-13110	50	5	provide	provide	VERB
ecj-13110	50	6	general	general	ADJ
ecj-13110	50	7	guidance	guidance	NOUN
ecj-13110	50	8	but	but	CCONJ
ecj-13110	50	9	are	be	AUX
ecj-13110	50	10	now	now	ADV
ecj-13110	50	11	outdated	outdate	VERB
ecj-13110	50	12	,	,	PUNCT
ecj-13110	50	13	failing	fail	VERB
ecj-13110	50	14	to	to	PART
ecj-13110	50	15	incorporate	incorporate	VERB
ecj-13110	50	16	recent	recent	ADJ
ecj-13110	50	17	advances	advance	NOUN
ecj-13110	50	18	in	in	ADP
ecj-13110	50	19	naloxone	naloxone	NOUN
ecj-13110	50	20	administration.6	administration.6	NOUN
ecj-13110	50	21	similarly	similarly	ADV
ecj-13110	50	22	,	,	PUNCT
ecj-13110	50	23	a	a	DET
ecj-13110	50	24	systematic	systematic	ADJ
ecj-13110	50	25	review	review	NOUN
ecj-13110	50	26	titled	title	VERB
ecj-13110	50	27	“	"	PUNCT
ecj-13110	50	28	management	management	NOUN
ecj-13110	50	29	of	of	ADP
ecj-13110	50	30	suspected	suspect	VERB
ecj-13110	50	31	opioid	opioid	ADJ
ecj-13110	50	32	overdose	overdose	NOUN
ecj-13110	50	33	with	with	ADP
ecj-13110	50	34	naloxone	naloxone	NOUN
ecj-13110	50	35	by	by	ADP
ecj-13110	50	36	emergency	emergency	NOUN
ecj-13110	50	37	services	service	NOUN
ecj-13110	50	38	,	,	PUNCT
ecj-13110	50	39	”	"	PUNCT
ecj-13110	50	40	focusing	focus	VERB
ecj-13110	50	41	on	on	ADP
ecj-13110	50	42	out	out	ADP
ecj-13110	50	43	-	-	PUNCT
ecj-13110	50	44	of	of	ADP
ecj-13110	50	45	-	-	PUNCT
ecj-13110	50	46	hospital	hospital	NOUN
ecj-13110	50	47	overdoses	overdose	NOUN
ecj-13110	50	48	,	,	PUNCT
ecj-13110	50	49	confirms	confirm	VERB
ecj-13110	50	50	naloxone	naloxone	PROPN
ecj-13110	50	51	’s	’s	PART
ecj-13110	50	52	efficacy	efficacy	NOUN
ecj-13110	50	53	as	as	ADP
ecj-13110	50	54	a	a	DET
ecj-13110	50	55	critical	critical	ADJ
ecj-13110	50	56	treatment	treatment	NOUN
ecj-13110	50	57	but	but	CCONJ
ecj-13110	50	58	is	be	AUX
ecj-13110	50	59	limited	limit	VERB
ecj-13110	50	60	by	by	ADP
ecj-13110	50	61	data	datum	NOUN
ecj-13110	50	62	variability	variability	NOUN
ecj-13110	50	63	and	and	CCONJ
ecj-13110	50	64	a	a	DET
ecj-13110	50	65	lack	lack	NOUN
ecj-13110	50	66	of	of	ADP
ecj-13110	50	67	long	long	ADJ
ecj-13110	50	68	-	-	PUNCT
ecj-13110	50	69	term	term	NOUN
ecj-13110	50	70	follow	follow	NOUN
ecj-13110	50	71	-	-	PUNCT
ecj-13110	50	72	up.7	up.7	NOUN
ecj-13110	50	73	lastly	lastly	ADV
ecj-13110	50	74	,	,	PUNCT
ecj-13110	50	75	the	the	DET
ecj-13110	50	76	american	american	ADJ
ecj-13110	50	77	heart	heart	PROPN
ecj-13110	50	78	association	association	PROPN
ecj-13110	50	79	(	(	PUNCT
ecj-13110	50	80	aha	aha	INTJ
ecj-13110	50	81	)	)	PUNCT
ecj-13110	50	82	scientific	scientific	ADJ
ecj-13110	50	83	statement	statement	NOUN
ecj-13110	50	84	emphasizes	emphasize	VERB
ecj-13110	50	85	naloxone	naloxone	ADJ
ecj-13110	50	86	administration	administration	NOUN
ecj-13110	50	87	alongside	alongside	ADP
ecj-13110	50	88	conventional	conventional	ADJ
ecj-13110	50	89	cpr	cpr	PROPN
ecj-13110	50	90	for	for	ADP
ecj-13110	50	91	opioid	opioid	NOUN
ecj-13110	50	92	-	-	PUNCT
ecj-13110	50	93	associated	associate	VERB
ecj-13110	50	94	out	out	ADP
ecj-13110	50	95	-	-	PUNCT
ecj-13110	50	96	of	of	ADP
ecj-13110	50	97	-	-	PUNCT
ecj-13110	50	98	hospital	hospital	NOUN
ecj-13110	50	99	cardiac	cardiac	ADJ
ecj-13110	50	100	arrest	arrest	NOUN
ecj-13110	50	101	(	(	PUNCT
ecj-13110	50	102	oa	oa	NOUN
ecj-13110	50	103	-	-	ADJ
ecj-13110	50	104	ohca	ohca	ADJ
ecj-13110	50	105	)	)	PUNCT
ecj-13110	50	106	yet	yet	ADV
ecj-13110	50	107	lacks	lack	VERB
ecj-13110	50	108	actionable	actionable	ADJ
ecj-13110	50	109	guidelines	guideline	NOUN
ecj-13110	50	110	on	on	ADP
ecj-13110	50	111	the	the	DET
ecj-13110	50	112	practical	practical	ADJ
ecj-13110	50	113	use	use	NOUN
ecj-13110	50	114	of	of	ADP
ecj-13110	50	115	intranasal	intranasal	NOUN
ecj-13110	50	116	(	(	PUNCT
ecj-13110	50	117	in	in	ADP
ecj-13110	50	118	)	)	PUNCT
ecj-13110	50	119	naloxone	naloxone	NOUN
ecj-13110	50	120	in	in	ADP
ecj-13110	50	121	prehospital	prehospital	NOUN
ecj-13110	50	122	settings.8	settings.8	VERB
ecj-13110	50	123	these	these	DET
ecj-13110	50	124	documents	document	NOUN
ecj-13110	50	125	offer	offer	VERB
ecj-13110	50	126	valuable	valuable	ADJ
ecj-13110	50	127	insights	insight	NOUN
ecj-13110	50	128	but	but	CCONJ
ecj-13110	50	129	underscore	underscore	VERB
ecj-13110	50	130	the	the	DET
ecj-13110	50	131	absence	absence	NOUN
ecj-13110	50	132	of	of	ADP
ecj-13110	50	133	specific	specific	ADJ
ecj-13110	50	134	,	,	PUNCT
ecj-13110	50	135	evidence	evidence	NOUN
ecj-13110	50	136	-	-	PUNCT
ecj-13110	50	137	based	base	VERB
ecj-13110	50	138	guidelines	guideline	NOUN
ecj-13110	50	139	.	.	PUNCT
ecj-13110	51	1	recent	recent	ADJ
ecj-13110	51	2	studies	study	NOUN
ecj-13110	51	3	have	have	AUX
ecj-13110	51	4	highlighted	highlight	VERB
ecj-13110	51	5	the	the	DET
ecj-13110	51	6	growing	grow	VERB
ecj-13110	51	7	role	role	NOUN
ecj-13110	51	8	of	of	ADP
ecj-13110	51	9	intranasal	intranasal	ADJ
ecj-13110	51	10	naloxone	naloxone	NOUN
ecj-13110	51	11	as	as	ADP
ecj-13110	51	12	a	a	DET
ecj-13110	51	13	practical	practical	ADJ
ecj-13110	51	14	,	,	PUNCT
ecj-13110	51	15	effective	effective	ADJ
ecj-13110	51	16	tool	tool	NOUN
ecj-13110	51	17	for	for	ADP
ecj-13110	51	18	prehospital	prehospital	ADJ
ecj-13110	51	19	overdose	overdose	NOUN
ecj-13110	51	20	interventions	intervention	NOUN
ecj-13110	51	21	,	,	PUNCT
ecj-13110	51	22	particularly	particularly	ADV
ecj-13110	51	23	in	in	ADP
ecj-13110	51	24	non	non	ADJ
ecj-13110	51	25	-	-	ADJ
ecj-13110	51	26	medical	medical	ADJ
ecj-13110	51	27	settings.9	settings.9	PROPN
ecj-13110	51	28	this	this	DET
ecj-13110	51	29	gap	gap	NOUN
ecj-13110	51	30	in	in	ADP
ecj-13110	51	31	the	the	DET
ecj-13110	51	32	literature	literature	NOUN
ecj-13110	51	33	emphasizes	emphasize	VERB
ecj-13110	51	34	the	the	DET
ecj-13110	51	35	need	need	NOUN
ecj-13110	51	36	for	for	ADP
ecj-13110	51	37	a	a	DET
ecj-13110	51	38	comprehensive	comprehensive	ADJ
ecj-13110	51	39	review	review	NOUN
ecj-13110	51	40	of	of	ADP
ecj-13110	51	41	current	current	ADJ
ecj-13110	51	42	evidence	evidence	NOUN
ecj-13110	51	43	to	to	PART
ecj-13110	51	44	inform	inform	VERB
ecj-13110	51	45	best	good	ADJ
ecj-13110	51	46	practices	practice	NOUN
ecj-13110	51	47	.	.	PUNCT
ecj-13110	52	1	therefore	therefore	ADV
ecj-13110	52	2	,	,	PUNCT
ecj-13110	52	3	this	this	DET
ecj-13110	52	4	review	review	NOUN
ecj-13110	52	5	aims	aim	VERB
ecj-13110	52	6	to	to	PART
ecj-13110	52	7	examine	examine	VERB
ecj-13110	52	8	the	the	DET
ecj-13110	52	9	latest	late	ADJ
ecj-13110	52	10	data	datum	NOUN
ecj-13110	52	11	,	,	PUNCT
ecj-13110	52	12	offering	offer	VERB
ecj-13110	52	13	a	a	DET
ecj-13110	52	14	methodologically	methodologically	ADV
ecj-13110	52	15	rigorous	rigorous	ADJ
ecj-13110	52	16	assessment	assessment	NOUN
ecj-13110	52	17	of	of	ADP
ecj-13110	52	18	the	the	DET
ecj-13110	52	19	current	current	ADJ
ecj-13110	52	20	state	state	NOUN
ecj-13110	52	21	of	of	ADP
ecj-13110	52	22	knowledge	knowledge	NOUN
ecj-13110	52	23	and	and	CCONJ
ecj-13110	52	24	identifying	identify	VERB
ecj-13110	52	25	optimal	optimal	ADJ
ecj-13110	52	26	strategies	strategy	NOUN
ecj-13110	52	27	for	for	ADP
ecj-13110	52	28	opioid	opioid	ADJ
ecj-13110	52	29	overdose	overdose	ADJ
ecj-13110	52	30	management	management	NOUN
ecj-13110	52	31	,	,	PUNCT
ecj-13110	52	32	with	with	ADP
ecj-13110	52	33	a	a	DET
ecj-13110	52	34	primary	primary	ADJ
ecj-13110	52	35	focus	focus	NOUN
ecj-13110	52	36	on	on	ADP
ecj-13110	52	37	prehospital	prehospital	ADJ
ecj-13110	52	38	environments	environment	NOUN
ecj-13110	52	39	.	.	PUNCT
ecj-13110	53	1	however	however	ADV
ecj-13110	53	2	,	,	PUNCT
ecj-13110	53	3	if	if	SCONJ
ecj-13110	53	4	the	the	DET
ecj-13110	53	5	availability	availability	NOUN
ecj-13110	53	6	of	of	ADP
ecj-13110	53	7	studies	study	NOUN
ecj-13110	53	8	solely	solely	ADV
ecj-13110	53	9	addressing	address	VERB
ecj-13110	53	10	prehospital	prehospital	NOUN
ecj-13110	53	11	care	care	NOUN
ecj-13110	53	12	is	be	AUX
ecj-13110	53	13	limited	limited	ADJ
ecj-13110	53	14	,	,	PUNCT
ecj-13110	53	15	relevant	relevant	ADJ
ecj-13110	53	16	data	datum	NOUN
ecj-13110	53	17	from	from	ADP
ecj-13110	53	18	other	other	ADJ
ecj-13110	53	19	settings	setting	NOUN
ecj-13110	53	20	may	may	AUX
ecj-13110	53	21	be	be	AUX
ecj-13110	53	22	considered	consider	VERB
ecj-13110	53	23	to	to	PART
ecj-13110	53	24	provide	provide	VERB
ecj-13110	53	25	a	a	DET
ecj-13110	53	26	more	more	ADV
ecj-13110	53	27	comprehensive	comprehensive	ADJ
ecj-13110	53	28	view	view	NOUN
ecj-13110	53	29	.	.	PUNCT
ecj-13110	54	1	the	the	DET
ecj-13110	54	2	aim	aim	NOUN
ecj-13110	54	3	of	of	ADP
ecj-13110	54	4	this	this	DET
ecj-13110	54	5	review	review	NOUN
ecj-13110	54	6	is	be	AUX
ecj-13110	54	7	to	to	PART
ecj-13110	54	8	examine	examine	VERB
ecj-13110	54	9	the	the	DET
ecj-13110	54	10	available	available	ADJ
ecj-13110	54	11	evidence	evidence	NOUN
ecj-13110	54	12	on	on	ADP
ecj-13110	54	13	the	the	DET
ecj-13110	54	14	effectiveness	effectiveness	NOUN
ecj-13110	54	15	of	of	ADP
ecj-13110	54	16	different	different	ADJ
ecj-13110	54	17	routes	route	NOUN
ecj-13110	54	18	of	of	ADP
ecj-13110	54	19	naloxone	naloxone	ADJ
ecj-13110	54	20	administration	administration	NOUN
ecj-13110	54	21	in	in	ADP
ecj-13110	54	22	opioid	opioid	ADJ
ecj-13110	54	23	overdoses	overdose	NOUN
ecj-13110	54	24	,	,	PUNCT
ecj-13110	54	25	with	with	ADP
ecj-13110	54	26	a	a	DET
ecj-13110	54	27	primary	primary	ADJ
ecj-13110	54	28	focus	focus	NOUN
ecj-13110	54	29	on	on	ADP
ecj-13110	54	30	prehospital	prehospital	ADJ
ecj-13110	54	31	settings	setting	NOUN
ecj-13110	54	32	and	and	CCONJ
ecj-13110	54	33	a	a	DET
ecj-13110	54	34	particular	particular	ADJ
ecj-13110	54	35	emphasis	emphasis	NOUN
ecj-13110	54	36	on	on	ADP
ecj-13110	54	37	comparing	compare	VERB
ecj-13110	54	38	intranasal	intranasal	NOUN
ecj-13110	54	39	,	,	PUNCT
ecj-13110	54	40	intramuscular	intramuscular	ADV
ecj-13110	54	41	(	(	PUNCT
ecj-13110	54	42	i	i	NOUN
ecj-13110	54	43	m	m	PROPN
ecj-13110	54	44	)	)	PUNCT
ecj-13110	54	45	,	,	PUNCT
ecj-13110	54	46	and	and	CCONJ
ecj-13110	54	47	intravenous	intravenous	ADJ
ecj-13110	54	48	(	(	PUNCT
ecj-13110	54	49	iv	iv	X
ecj-13110	54	50	)	)	PUNCT
ecj-13110	54	51	routes	route	NOUN
ecj-13110	54	52	.	.	PUNCT
ecj-13110	55	1	to	to	PART
ecj-13110	55	2	address	address	VERB
ecj-13110	55	3	this	this	PRON
ecj-13110	55	4	,	,	PUNCT
ecj-13110	55	5	a	a	DET
ecj-13110	55	6	search	search	NOUN
ecj-13110	55	7	was	be	AUX
ecj-13110	55	8	conducted	conduct	VERB
ecj-13110	55	9	on	on	ADP
ecj-13110	55	10	pubmed	pubmed	PROPN
ecj-13110	55	11	,	,	PUNCT
ecj-13110	55	12	including	include	VERB
ecj-13110	55	13	articles	article	NOUN
ecj-13110	55	14	published	publish	VERB
ecj-13110	55	15	up	up	ADP
ecj-13110	55	16	to	to	ADP
ecj-13110	55	17	march	march	PROPN
ecj-13110	55	18	28	28	NUM
ecj-13110	55	19	,	,	PUNCT
ecj-13110	55	20	2023	2023	NUM
ecj-13110	55	21	.	.	PUNCT
ecj-13110	56	1	materials	material	NOUN
ecj-13110	56	2	and	and	CCONJ
ecj-13110	56	3	methods	method	NOUN
ecj-13110	56	4	a	a	DET
ecj-13110	56	5	narrative	narrative	NOUN
ecj-13110	56	6	review	review	NOUN
ecj-13110	56	7	was	be	AUX
ecj-13110	56	8	conducted	conduct	VERB
ecj-13110	56	9	in	in	ADP
ecj-13110	56	10	compliance	compliance	NOUN
ecj-13110	56	11	with	with	ADP
ecj-13110	56	12	the	the	DET
ecj-13110	56	13	preferred	preferred	ADJ
ecj-13110	56	14	reporting	reporting	NOUN
ecj-13110	56	15	items	item	NOUN
ecj-13110	56	16	for	for	ADP
ecj-13110	56	17	systematic	systematic	ADJ
ecj-13110	56	18	reviews	review	NOUN
ecj-13110	56	19	and	and	CCONJ
ecj-13110	56	20	meta	meta	ADJ
ecj-13110	56	21	-	-	PUNCT
ecj-13110	56	22	analyses	analysis	NOUN
ecj-13110	56	23	statement	statement	NOUN
ecj-13110	56	24	(	(	PUNCT
ecj-13110	56	25	prisma)10	prisma)10	NOUN
ecj-13110	56	26	and	and	CCONJ
ecj-13110	56	27	the	the	DET
ecj-13110	56	28	guidelines	guideline	NOUN
ecj-13110	56	29	for	for	ADP
ecj-13110	56	30	writing	write	VERB
ecj-13110	56	31	a	a	DET
ecj-13110	56	32	narrative	narrative	NOUN
ecj-13110	56	33	review	review	NOUN
ecj-13110	56	34	to	to	PART
ecj-13110	56	35	be	be	AUX
ecj-13110	56	36	published	publish	VERB
ecj-13110	56	37	in	in	ADP
ecj-13110	56	38	peer	peer	NOUN
ecj-13110	56	39	-	-	PUNCT
ecj-13110	56	40	reviewed	review	VERB
ecj-13110	56	41	journals.11	journals.11	PROPN
ecj-13110	56	42	search	search	NOUN
ecj-13110	56	43	strategy	strategy	NOUN
ecj-13110	56	44	initially	initially	ADV
ecj-13110	56	45	,	,	PUNCT
ecj-13110	56	46	several	several	ADJ
ecj-13110	56	47	key	key	ADJ
ecj-13110	56	48	words	word	NOUN
ecj-13110	56	49	were	be	AUX
ecj-13110	56	50	selected	select	VERB
ecj-13110	56	51	based	base	VERB
ecj-13110	56	52	on	on	ADP
ecj-13110	56	53	the	the	DET
ecj-13110	56	54	recommendations	recommendation	NOUN
ecj-13110	56	55	of	of	ADP
ecj-13110	56	56	experts	expert	NOUN
ecj-13110	56	57	in	in	ADP
ecj-13110	56	58	prehospital	prehospital	ADJ
ecj-13110	56	59	emergency	emergency	NOUN
ecj-13110	56	60	care	care	NOUN
ecj-13110	56	61	and	and	CCONJ
ecj-13110	56	62	verified	verify	VERB
ecj-13110	56	63	using	use	VERB
ecj-13110	56	64	the	the	DET
ecj-13110	56	65	mesh	mesh	NOUN
ecj-13110	56	66	thesaurus	thesaurus	NOUN
ecj-13110	56	67	.	.	PUNCT
ecj-13110	57	1	pubmed	pubmed	PROPN
ecj-13110	57	2	was	be	AUX
ecj-13110	57	3	used	use	VERB
ecj-13110	57	4	as	as	ADP
ecj-13110	57	5	the	the	DET
ecj-13110	57	6	primary	primary	ADJ
ecj-13110	57	7	source	source	NOUN
ecj-13110	57	8	for	for	ADP
ecj-13110	57	9	the	the	DET
ecj-13110	57	10	search	search	NOUN
ecj-13110	57	11	.	.	PUNCT
ecj-13110	58	1	the	the	DET
ecj-13110	58	2	search	search	NOUN
ecj-13110	58	3	included	include	VERB
ecj-13110	58	4	terms	term	NOUN
ecj-13110	58	5	such	such	ADJ
ecj-13110	58	6	as	as	ADP
ecj-13110	58	7	“	"	PUNCT
ecj-13110	58	8	naloxone	naloxone	NOUN
ecj-13110	58	9	,	,	PUNCT
ecj-13110	58	10	”	"	PUNCT
ecj-13110	58	11	“	"	PUNCT
ecj-13110	58	12	opioid	opioid	ADJ
ecj-13110	58	13	overdose	overdose	ADV
ecj-13110	58	14	,	,	PUNCT
ecj-13110	58	15	”	"	PUNCT
ecj-13110	58	16	“	"	PUNCT
ecj-13110	58	17	intranasal	intranasal	ADJ
ecj-13110	58	18	administration	administration	NOUN
ecj-13110	58	19	,	,	PUNCT
ecj-13110	58	20	”	"	PUNCT
ecj-13110	58	21	and	and	CCONJ
ecj-13110	58	22	“	"	PUNCT
ecj-13110	58	23	prehospital	prehospital	ADJ
ecj-13110	58	24	emergency	emergency	NOUN
ecj-13110	58	25	care	care	NOUN
ecj-13110	58	26	,	,	PUNCT
ecj-13110	58	27	”	"	PUNCT
ecj-13110	58	28	with	with	ADP
ecj-13110	58	29	boolean	boolean	ADJ
ecj-13110	58	30	operators	operator	NOUN
ecj-13110	58	31	to	to	PART
ecj-13110	58	32	refine	refine	VERB
ecj-13110	58	33	the	the	DET
ecj-13110	58	34	scope	scope	NOUN
ecj-13110	58	35	.	.	PUNCT
ecj-13110	59	1	the	the	DET
ecj-13110	59	2	search	search	NOUN
ecj-13110	59	3	was	be	AUX
ecj-13110	59	4	completed	complete	VERB
ecj-13110	59	5	on	on	ADP
ecj-13110	59	6	march	march	PROPN
ecj-13110	59	7	28	28	NUM
ecj-13110	59	8	,	,	PUNCT
ecj-13110	59	9	2023	2023	NUM
ecj-13110	59	10	,	,	PUNCT
ecj-13110	59	11	and	and	CCONJ
ecj-13110	59	12	all	all	DET
ecj-13110	59	13	primary	primary	ADJ
ecj-13110	59	14	-	-	PUNCT
ecj-13110	59	15	level	level	NOUN
ecj-13110	59	16	studies	study	NOUN
ecj-13110	59	17	published	publish	VERB
ecj-13110	59	18	up	up	ADP
ecj-13110	59	19	to	to	ADP
ecj-13110	59	20	that	that	DET
ecj-13110	59	21	date	date	NOUN
ecj-13110	59	22	were	be	AUX
ecj-13110	59	23	retrieved	retrieve	VERB
ecj-13110	59	24	,	,	PUNCT
ecj-13110	59	25	with	with	ADP
ecj-13110	59	26	a	a	DET
ecj-13110	59	27	filter	filter	NOUN
ecj-13110	59	28	set	set	VERB
ecj-13110	59	29	for	for	ADP
ecj-13110	59	30	no	no	DET
ecj-13110	59	31	more	more	ADJ
ecj-13110	59	32	than	than	ADP
ecj-13110	59	33	6	6	NUM
ecj-13110	59	34	years	year	NOUN
ecj-13110	59	35	back	back	ADV
ecj-13110	59	36	(	(	PUNCT
ecj-13110	59	37	2017	2017	NUM
ecj-13110	59	38	-	-	SYM
ecj-13110	59	39	2023	2023	NUM
ecj-13110	59	40	)	)	PUNCT
ecj-13110	59	41	.	.	PUNCT
ecj-13110	60	1	no	no	DET
ecj-13110	60	2	contact	contact	NOUN
ecj-13110	60	3	with	with	ADP
ecj-13110	60	4	authors	author	NOUN
ecj-13110	60	5	was	be	AUX
ecj-13110	60	6	necessary	necessary	ADJ
ecj-13110	60	7	.	.	PUNCT
ecj-13110	61	1	additional	additional	ADJ
ecj-13110	61	2	filters	filter	NOUN
ecj-13110	61	3	applied	apply	VERB
ecj-13110	61	4	included	include	VERB
ecj-13110	61	5	study	study	NOUN
ecj-13110	61	6	types	type	NOUN
ecj-13110	61	7	such	such	ADJ
ecj-13110	61	8	as	as	ADP
ecj-13110	61	9	“	"	PUNCT
ecj-13110	61	10	clinical	clinical	ADJ
ecj-13110	61	11	trial	trial	NOUN
ecj-13110	61	12	,	,	PUNCT
ecj-13110	61	13	”	"	PUNCT
ecj-13110	61	14	“	"	PUNCT
ecj-13110	61	15	controlled	control	VERB
ecj-13110	61	16	clinical	clinical	ADJ
ecj-13110	61	17	trial	trial	NOUN
ecj-13110	61	18	,	,	PUNCT
ecj-13110	61	19	”	"	PUNCT
ecj-13110	61	20	“	"	PUNCT
ecj-13110	61	21	multicenter	multicenter	ADJ
ecj-13110	61	22	study	study	NOUN
ecj-13110	61	23	,	,	PUNCT
ecj-13110	61	24	”	"	PUNCT
ecj-13110	61	25	“	"	PUNCT
ecj-13110	61	26	observational	observational	ADJ
ecj-13110	61	27	study	study	NOUN
ecj-13110	61	28	,	,	PUNCT
ecj-13110	61	29	”	"	PUNCT
ecj-13110	61	30	and	and	CCONJ
ecj-13110	61	31	“	"	PUNCT
ecj-13110	61	32	randomized	randomize	VERB
ecj-13110	61	33	controlled	control	VERB
ecj-13110	61	34	trial	trial	NOUN
ecj-13110	61	35	.	.	PUNCT
ecj-13110	61	36	”	"	PUNCT
ecj-13110	62	1	using	use	VERB
ecj-13110	62	2	this	this	DET
ecj-13110	62	3	search	search	NOUN
ecj-13110	62	4	strategy	strategy	NOUN
ecj-13110	62	5	,	,	PUNCT
ecj-13110	62	6	111	111	NUM
ecj-13110	62	7	results	result	NOUN
ecj-13110	62	8	were	be	AUX
ecj-13110	62	9	available	available	ADJ
ecj-13110	62	10	as	as	ADP
ecj-13110	62	11	of	of	ADP
ecj-13110	62	12	march	march	PROPN
ecj-13110	62	13	28	28	NUM
ecj-13110	62	14	,	,	PUNCT
ecj-13110	62	15	2023	2023	NUM
ecj-13110	62	16	.	.	PUNCT
ecj-13110	63	1	all	all	DET
ecj-13110	63	2	studies	study	NOUN
ecj-13110	63	3	relevant	relevant	ADJ
ecj-13110	63	4	to	to	ADP
ecj-13110	63	5	the	the	DET
ecj-13110	63	6	research	research	NOUN
ecj-13110	63	7	questions	question	NOUN
ecj-13110	63	8	were	be	AUX
ecj-13110	63	9	selected	select	VERB
ecj-13110	63	10	.	.	PUNCT
ecj-13110	64	1	eligibility	eligibility	NOUN
ecj-13110	64	2	criteria	criteria	VERB
ecj-13110	64	3	the	the	DET
ecj-13110	64	4	research	research	NOUN
ecj-13110	64	5	question	question	NOUN
ecj-13110	64	6	was	be	AUX
ecj-13110	64	7	constructed	construct	VERB
ecj-13110	64	8	using	use	VERB
ecj-13110	64	9	the	the	DET
ecj-13110	64	10	pico	pico	NOUN
ecj-13110	64	11	framework	framework	NOUN
ecj-13110	64	12	(	(	PUNCT
ecj-13110	64	13	table	table	NOUN
ecj-13110	64	14	1	1	NUM
ecj-13110	64	15	)	)	PUNCT
ecj-13110	64	16	.	.	PUNCT
ecj-13110	65	1	to	to	PART
ecj-13110	65	2	ensure	ensure	VERB
ecj-13110	65	3	a	a	DET
ecj-13110	65	4	comprehensive	comprehensive	ADJ
ecj-13110	65	5	analysis	analysis	NOUN
ecj-13110	65	6	,	,	PUNCT
ecj-13110	65	7	studies	study	NOUN
ecj-13110	65	8	focusing	focus	VERB
ecj-13110	65	9	on	on	ADP
ecj-13110	65	10	cases	case	NOUN
ecj-13110	65	11	of	of	ADP
ecj-13110	65	12	opioid	opioid	ADJ
ecj-13110	65	13	overdose	overdose	NOUN
ecj-13110	65	14	in	in	ADP
ecj-13110	65	15	a	a	DET
ecj-13110	65	16	prehospital	prehospital	NOUN
ecj-13110	65	17	setting	setting	NOUN
ecj-13110	65	18	were	be	AUX
ecj-13110	65	19	prioritized	prioritize	VERB
ecj-13110	65	20	.	.	PUNCT
ecj-13110	66	1	additionally	additionally	ADV
ecj-13110	66	2	,	,	PUNCT
ecj-13110	66	3	studies	study	NOUN
ecj-13110	66	4	conducted	conduct	VERB
ecj-13110	66	5	in	in	ADP
ecj-13110	66	6	community	community	NOUN
ecj-13110	66	7	or	or	CCONJ
ecj-13110	66	8	controlled	control	VERB
ecj-13110	66	9	research	research	NOUN
ecj-13110	66	10	settings	setting	NOUN
ecj-13110	66	11	were	be	AUX
ecj-13110	66	12	included	include	VERB
ecj-13110	66	13	to	to	PART
ecj-13110	66	14	encompass	encompass	VERB
ecj-13110	66	15	a	a	DET
ecj-13110	66	16	broad	broad	ADJ
ecj-13110	66	17	range	range	NOUN
ecj-13110	66	18	of	of	ADP
ecj-13110	66	19	evidence	evidence	NOUN
ecj-13110	66	20	.	.	PUNCT
ecj-13110	67	1	this	this	DET
ecj-13110	67	2	approach	approach	NOUN
ecj-13110	67	3	provides	provide	VERB
ecj-13110	67	4	a	a	DET
ecj-13110	67	5	balance	balance	NOUN
ecj-13110	67	6	between	between	ADP
ecj-13110	67	7	controlled	control	VERB
ecj-13110	67	8	experimental	experimental	ADJ
ecj-13110	67	9	data	datum	NOUN
ecj-13110	67	10	,	,	PUNCT
ecj-13110	67	11	which	which	PRON
ecj-13110	67	12	offer	offer	VERB
ecj-13110	67	13	robust	robust	ADJ
ecj-13110	67	14	pharmacological	pharmacological	ADJ
ecj-13110	67	15	insights	insight	NOUN
ecj-13110	67	16	,	,	PUNCT
ecj-13110	67	17	and	and	CCONJ
ecj-13110	67	18	real	real	ADJ
ecj-13110	67	19	-	-	PUNCT
ecj-13110	67	20	world	world	NOUN
ecj-13110	67	21	studies	study	NOUN
ecj-13110	67	22	,	,	PUNCT
ecj-13110	67	23	which	which	PRON
ecj-13110	67	24	capture	capture	VERB
ecj-13110	67	25	the	the	DET
ecj-13110	67	26	practical	practical	ADJ
ecj-13110	67	27	challenges	challenge	NOUN
ecj-13110	67	28	of	of	ADP
ecj-13110	67	29	managing	manage	VERB
ecj-13110	67	30	opioid	opioid	ADJ
ecj-13110	67	31	overdose	overdose	ADV
ecj-13110	67	32	.	.	PUNCT
ecj-13110	68	1	the	the	DET
ecj-13110	68	2	intervention	intervention	NOUN
ecj-13110	68	3	studied	study	VERB
ecj-13110	68	4	was	be	AUX
ecj-13110	68	5	intranasal	intranasal	ADJ
ecj-13110	68	6	naloxone	naloxone	ADJ
ecj-13110	68	7	administration	administration	NOUN
ecj-13110	68	8	,	,	PUNCT
ecj-13110	68	9	and	and	CCONJ
ecj-13110	68	10	the	the	DET
ecj-13110	68	11	comparison	comparison	NOUN
ecj-13110	68	12	was	be	AUX
ecj-13110	68	13	made	make	VERB
ecj-13110	68	14	with	with	ADP
ecj-13110	68	15	intramuscular	intramuscular	ADJ
ecj-13110	68	16	or	or	CCONJ
ecj-13110	68	17	intravenous	intravenous	ADJ
ecj-13110	68	18	naloxone	naloxone	ADJ
ecj-13110	68	19	administration	administration	NOUN
ecj-13110	68	20	.	.	PUNCT
ecj-13110	69	1	the	the	DET
ecj-13110	69	2	primary	primary	ADJ
ecj-13110	69	3	outcomes	outcome	NOUN
ecj-13110	69	4	observed	observe	VERB
ecj-13110	69	5	were	be	AUX
ecj-13110	69	6	the	the	DET
ecj-13110	69	7	restoration	restoration	NOUN
ecj-13110	69	8	of	of	ADP
ecj-13110	69	9	spontaneous	spontaneous	ADJ
ecj-13110	69	10	breathing	breathing	NOUN
ecj-13110	69	11	,	,	PUNCT
ecj-13110	69	12	improvement	improvement	NOUN
ecj-13110	69	13	in	in	ADP
ecj-13110	69	14	the	the	DET
ecj-13110	69	15	glasgow	glasgow	PROPN
ecj-13110	69	16	coma	coma	NOUN
ecj-13110	69	17	scale	scale	NOUN
ecj-13110	69	18	(	(	PUNCT
ecj-13110	69	19	gcs	gcs	PROPN
ecj-13110	69	20	)	)	PUNCT
ecj-13110	69	21	score	score	NOUN
ecj-13110	69	22	to	to	ADP
ecj-13110	69	23	at	at	ADV
ecj-13110	69	24	least	least	ADJ
ecj-13110	69	25	8	8	NUM
ecj-13110	69	26	,	,	PUNCT
ecj-13110	69	27	and	and	CCONJ
ecj-13110	69	28	the	the	DET
ecj-13110	69	29	onset	onset	NOUN
ecj-13110	69	30	of	of	ADP
ecj-13110	69	31	action	action	NOUN
ecj-13110	69	32	of	of	ADP
ecj-13110	69	33	naloxone	naloxone	NOUN
ecj-13110	69	34	,	,	PUNCT
ecj-13110	69	35	defined	define	VERB
ecj-13110	69	36	by	by	ADP
ecj-13110	69	37	the	the	DET
ecj-13110	69	38	time	time	NOUN
ecj-13110	69	39	to	to	PART
ecj-13110	69	40	improvement	improvement	VERB
ecj-13110	69	41	in	in	ADP
ecj-13110	69	42	respiratory	respiratory	ADJ
ecj-13110	69	43	rate	rate	NOUN
ecj-13110	69	44	and	and	CCONJ
ecj-13110	69	45	peripheral	peripheral	ADJ
ecj-13110	69	46	oxygen	oxygen	NOUN
ecj-13110	69	47	saturation	saturation	NOUN
ecj-13110	69	48	.	.	PUNCT
ecj-13110	70	1	secondary	secondary	ADJ
ecj-13110	70	2	outcomes	outcome	NOUN
ecj-13110	70	3	included	include	VERB
ecj-13110	70	4	clinical	clinical	ADJ
ecj-13110	70	5	stabilization	stabilization	NOUN
ecj-13110	70	6	and	and	CCONJ
ecj-13110	70	7	the	the	DET
ecj-13110	70	8	need	need	NOUN
ecj-13110	70	9	for	for	ADP
ecj-13110	70	10	additional	additional	ADJ
ecj-13110	70	11	naloxone	naloxone	ADJ
ecj-13110	70	12	administration	administration	NOUN
ecj-13110	70	13	.	.	PUNCT
ecj-13110	71	1	descriptive	descriptive	ADJ
ecj-13110	71	2	clinical	clinical	ADJ
ecj-13110	71	3	studies	study	NOUN
ecj-13110	71	4	and	and	CCONJ
ecj-13110	71	5	randomized	randomize	VERB
ecj-13110	71	6	controlled	control	VERB
ecj-13110	71	7	trials	trial	NOUN
ecj-13110	71	8	(	(	PUNCT
ecj-13110	71	9	rcts	rct	NOUN
ecj-13110	71	10	)	)	PUNCT
ecj-13110	71	11	involving	involve	VERB
ecj-13110	71	12	adult	adult	NOUN
ecj-13110	71	13	patients	patient	NOUN
ecj-13110	71	14	were	be	AUX
ecj-13110	71	15	included	include	VERB
ecj-13110	71	16	.	.	PUNCT
ecj-13110	72	1	exclusion	exclusion	NOUN
ecj-13110	72	2	criteria	criterion	NOUN
ecj-13110	72	3	were	be	AUX
ecj-13110	72	4	the	the	DET
ecj-13110	72	5	absence	absence	NOUN
ecj-13110	72	6	of	of	ADP
ecj-13110	72	7	data	datum	NOUN
ecj-13110	72	8	on	on	ADP
ecj-13110	72	9	naloxone	naloxone	ADJ
ecj-13110	72	10	route	route	NOUN
ecj-13110	72	11	and	and	CCONJ
ecj-13110	72	12	dosage	dosage	NOUN
ecj-13110	72	13	and	and	CCONJ
ecj-13110	72	14	studies	study	NOUN
ecj-13110	72	15	focusing	focus	VERB
ecj-13110	72	16	on	on	ADP
ecj-13110	72	17	the	the	DET
ecj-13110	72	18	treatment	treatment	NOUN
ecj-13110	72	19	of	of	ADP
ecj-13110	72	20	chronic	chronic	ADJ
ecj-13110	72	21	opioid	opioid	ADJ
ecj-13110	72	22	dependence	dependence	NOUN
ecj-13110	72	23	.	.	PUNCT
ecj-13110	73	1	full	full	ADJ
ecj-13110	73	2	-	-	PUNCT
ecj-13110	73	3	text	text	NOUN
ecj-13110	73	4	articles	article	NOUN
ecj-13110	73	5	of	of	ADP
ecj-13110	73	6	selected	select	VERB
ecj-13110	73	7	records	record	NOUN
ecj-13110	73	8	were	be	AUX
ecj-13110	73	9	retrieved	retrieve	VERB
ecj-13110	73	10	,	,	PUNCT
ecj-13110	73	11	and	and	CCONJ
ecj-13110	73	12	relevant	relevant	ADJ
ecj-13110	73	13	articles	article	NOUN
ecj-13110	73	14	were	be	AUX
ecj-13110	73	15	summarized	summarize	VERB
ecj-13110	73	16	using	use	VERB
ecj-13110	73	17	a	a	DET
ecj-13110	73	18	checklist	checklist	NOUN
ecj-13110	73	19	designed	design	VERB
ecj-13110	73	20	based	base	VERB
ecj-13110	73	21	on	on	ADP
ecj-13110	73	22	prisma	prisma	PROPN
ecj-13110	73	23	protocols	protocol	NOUN
ecj-13110	73	24	.	.	PUNCT
ecj-13110	74	1	the	the	DET
ecj-13110	74	2	data	datum	NOUN
ecj-13110	74	3	collected	collect	VERB
ecj-13110	74	4	in	in	ADP
ecj-13110	74	5	the	the	DET
ecj-13110	74	6	checklist	checklist	NOUN
ecj-13110	74	7	included	include	VERB
ecj-13110	74	8	the	the	DET
ecj-13110	74	9	name	name	NOUN
ecj-13110	74	10	of	of	ADP
ecj-13110	74	11	the	the	DET
ecj-13110	74	12	first	first	ADJ
ecj-13110	74	13	author	author	NOUN
ecj-13110	74	14	,	,	PUNCT
ecj-13110	74	15	publication	publication	NOUN
ecj-13110	74	16	year	year	NOUN
ecj-13110	74	17	,	,	PUNCT
ecj-13110	74	18	patient	patient	ADJ
ecj-13110	74	19	characteristics	characteristic	NOUN
ecj-13110	74	20	,	,	PUNCT
ecj-13110	74	21	naloxone	naloxone	ADJ
ecj-13110	74	22	administration	administration	NOUN
ecj-13110	74	23	route	route	NOUN
ecj-13110	74	24	,	,	PUNCT
ecj-13110	74	25	dosage	dosage	NOUN
ecj-13110	74	26	,	,	PUNCT
ecj-13110	74	27	and	and	CCONJ
ecj-13110	74	28	outcomes	outcome	NOUN
ecj-13110	74	29	.	.	PUNCT
ecj-13110	75	1	studies	study	NOUN
ecj-13110	75	2	selection	selection	NOUN
ecj-13110	75	3	records	record	NOUN
ecj-13110	75	4	were	be	AUX
ecj-13110	75	5	identified	identify	VERB
ecj-13110	75	6	,	,	PUNCT
ecj-13110	75	7	screened	screen	VERB
ecj-13110	75	8	,	,	PUNCT
ecj-13110	75	9	and	and	CCONJ
ecj-13110	75	10	assessed	assess	VERB
ecj-13110	75	11	for	for	ADP
ecj-13110	75	12	eligibility	eligibility	NOUN
ecj-13110	75	13	.	.	PUNCT
ecj-13110	76	1	review	review	NOUN
ecj-13110	77	1	[	[	X
ecj-13110	77	2	page	page	NOUN
ecj-13110	77	3	42	42	NUM
ecj-13110	77	4	]	]	PUNCT
ecj-13110	78	1	[	[	X
ecj-13110	78	2	emergency	emergency	NOUN
ecj-13110	78	3	care	care	NOUN
ecj-13110	78	4	journal	journal	NOUN
ecj-13110	78	5	2025	2025	NUM
ecj-13110	78	6	;	;	PUNCT
ecj-13110	78	7	21:13110	21:13110	NUM
ecj-13110	78	8	]	]	PUNCT
ecj-13110	78	9	table	table	NOUN
ecj-13110	78	10	1	1	NUM
ecj-13110	78	11	.	.	PUNCT
ecj-13110	78	12	question	question	NOUN
ecj-13110	78	13	according	accord	VERB
ecj-13110	78	14	to	to	ADP
ecj-13110	78	15	the	the	DET
ecj-13110	78	16	pico	pico	NOUN
ecj-13110	78	17	method	method	NOUN
ecj-13110	78	18	.	.	PUNCT
ecj-13110	79	1	pico	pico	NOUN
ecj-13110	79	2	structure	structure	NOUN
ecj-13110	79	3	problem	problem	NOUN
ecj-13110	79	4	(	(	PUNCT
ecj-13110	79	5	p	p	NOUN
ecj-13110	79	6	)	)	PUNCT
ecj-13110	79	7	opioid	opioid	ADJ
ecj-13110	79	8	overdose	overdose	NOUN
ecj-13110	79	9	in	in	ADP
ecj-13110	79	10	a	a	DET
ecj-13110	79	11	prehospital	prehospital	NOUN
ecj-13110	79	12	setting	set	VERB
ecj-13110	79	13	intervention	intervention	NOUN
ecj-13110	79	14	(	(	PUNCT
ecj-13110	79	15	i	i	NOUN
ecj-13110	79	16	)	)	PUNCT
ecj-13110	79	17	intranasal	intranasal	ADJ
ecj-13110	79	18	naloxone	naloxone	ADJ
ecj-13110	79	19	administration	administration	NOUN
ecj-13110	79	20	comparison	comparison	NOUN
ecj-13110	79	21	(	(	PUNCT
ecj-13110	79	22	c	c	NOUN
ecj-13110	79	23	)	)	PUNCT
ecj-13110	79	24	intramuscular	intramuscular	ADJ
ecj-13110	79	25	/	/	SYM
ecj-13110	79	26	intravenous	intravenous	ADJ
ecj-13110	79	27	naloxone	naloxone	ADJ
ecj-13110	79	28	administration	administration	NOUN
ecj-13110	79	29	/	/	SYM
ecj-13110	79	30	other	other	ADJ
ecj-13110	79	31	outcome	outcome	NOUN
ecj-13110	79	32	(	(	PUNCT
ecj-13110	79	33	o	o	NOUN
ecj-13110	79	34	)	)	PUNCT
ecj-13110	79	35	success	success	NOUN
ecj-13110	79	36	rate	rate	NOUN
ecj-13110	79	37	and	and	CCONJ
ecj-13110	79	38	onset	onset	NOUN
ecj-13110	79	39	of	of	ADP
ecj-13110	79	40	action	action	NOUN
ecj-13110	79	41	the	the	DET
ecj-13110	79	42	screening	screening	NOUN
ecj-13110	79	43	process	process	NOUN
ecj-13110	79	44	involved	involve	VERB
ecj-13110	79	45	reviewing	review	VERB
ecj-13110	79	46	abstracts	abstract	NOUN
ecj-13110	79	47	and	and	CCONJ
ecj-13110	79	48	full	full	ADJ
ecj-13110	79	49	-	-	PUNCT
ecj-13110	79	50	text	text	NOUN
ecj-13110	79	51	articles	article	NOUN
ecj-13110	79	52	to	to	PART
ecj-13110	79	53	exclude	exclude	VERB
ecj-13110	79	54	studies	study	NOUN
ecj-13110	79	55	not	not	PART
ecj-13110	79	56	aligned	align	VERB
ecj-13110	79	57	with	with	ADP
ecj-13110	79	58	the	the	DET
ecj-13110	79	59	research	research	NOUN
ecj-13110	79	60	objectives	objective	NOUN
ecj-13110	79	61	.	.	PUNCT
ecj-13110	80	1	studies	study	NOUN
ecj-13110	80	2	were	be	AUX
ecj-13110	80	3	excluded	exclude	VERB
ecj-13110	80	4	if	if	SCONJ
ecj-13110	80	5	they	they	PRON
ecj-13110	80	6	focused	focus	VERB
ecj-13110	80	7	on	on	ADP
ecj-13110	80	8	chronic	chronic	ADJ
ecj-13110	80	9	opioid	opioid	NOUN
ecj-13110	80	10	use	use	VERB
ecj-13110	80	11	disorder	disorder	NOUN
ecj-13110	80	12	,	,	PUNCT
ecj-13110	80	13	economic	economic	ADJ
ecj-13110	80	14	analyses	analysis	NOUN
ecj-13110	80	15	of	of	ADP
ecj-13110	80	16	the	the	DET
ecj-13110	80	17	opioid	opioid	ADJ
ecj-13110	80	18	epidemic	epidemic	NOUN
ecj-13110	80	19	,	,	PUNCT
ecj-13110	80	20	or	or	CCONJ
ecj-13110	80	21	overdose	overdose	NOUN
ecj-13110	80	22	prevention	prevention	NOUN
ecj-13110	80	23	programs	program	NOUN
ecj-13110	80	24	unrelated	unrelated	ADJ
ecj-13110	80	25	to	to	ADP
ecj-13110	80	26	naloxone	naloxone	ADJ
ecj-13110	80	27	administration	administration	NOUN
ecj-13110	80	28	.	.	PUNCT
ecj-13110	81	1	to	to	PART
ecj-13110	81	2	assess	assess	VERB
ecj-13110	81	3	the	the	DET
ecj-13110	81	4	methodological	methodological	ADJ
ecj-13110	81	5	quality	quality	NOUN
ecj-13110	81	6	and	and	CCONJ
ecj-13110	81	7	homogeneity	homogeneity	NOUN
ecj-13110	81	8	of	of	ADP
ecj-13110	81	9	the	the	DET
ecj-13110	81	10	studies	study	NOUN
ecj-13110	81	11	included	include	VERB
ecj-13110	81	12	in	in	ADP
ecj-13110	81	13	the	the	DET
ecj-13110	81	14	review	review	NOUN
ecj-13110	81	15	,	,	PUNCT
ecj-13110	81	16	the	the	DET
ecj-13110	81	17	method	method	NOUN
ecj-13110	81	18	proposed	propose	VERB
ecj-13110	81	19	by	by	ADP
ecj-13110	81	20	dixon	dixon	PROPN
ecj-13110	81	21	-	-	PUNCT
ecj-13110	81	22	woods	wood	NOUN
ecj-13110	81	23	was	be	AUX
ecj-13110	81	24	used	use	VERB
ecj-13110	81	25	by	by	ADP
ecj-13110	81	26	means	mean	NOUN
ecj-13110	81	27	of	of	ADP
ecj-13110	81	28	a	a	DET
ecj-13110	81	29	specific	specific	ADJ
ecj-13110	81	30	checklist.12	checklist.12	NOUN
ecj-13110	81	31	this	this	DET
ecj-13110	81	32	checklist	checklist	NOUN
ecj-13110	81	33	comprises	comprise	VERB
ecj-13110	81	34	five	five	NUM
ecj-13110	81	35	domains	domain	NOUN
ecj-13110	81	36	to	to	PART
ecj-13110	81	37	assess	assess	VERB
ecj-13110	81	38	the	the	DET
ecj-13110	81	39	methodological	methodological	ADJ
ecj-13110	81	40	quality	quality	NOUN
ecj-13110	81	41	of	of	ADP
ecj-13110	81	42	the	the	DET
ecj-13110	81	43	studies	study	NOUN
ecj-13110	81	44	,	,	PUNCT
ecj-13110	81	45	and	and	CCONJ
ecj-13110	81	46	each	each	DET
ecj-13110	81	47	article	article	NOUN
ecj-13110	81	48	was	be	AUX
ecj-13110	81	49	assigned	assign	VERB
ecj-13110	81	50	an	an	DET
ecj-13110	81	51	overall	overall	ADJ
ecj-13110	81	52	rating	rating	NOUN
ecj-13110	81	53	based	base	VERB
ecj-13110	81	54	on	on	ADP
ecj-13110	81	55	the	the	DET
ecj-13110	81	56	assessment	assessment	NOUN
ecj-13110	81	57	of	of	ADP
ecj-13110	81	58	these	these	DET
ecj-13110	81	59	domains	domain	NOUN
ecj-13110	81	60	.	.	PUNCT
ecj-13110	82	1	studies	study	NOUN
ecj-13110	82	2	that	that	PRON
ecj-13110	82	3	received	receive	VERB
ecj-13110	82	4	a	a	DET
ecj-13110	82	5	score	score	NOUN
ecj-13110	82	6	of	of	ADP
ecj-13110	82	7	less	less	ADJ
ecj-13110	82	8	than	than	ADP
ecj-13110	82	9	3	3	NUM
ecj-13110	82	10	“	"	PUNCT
ecj-13110	82	11	yes	yes	INTJ
ecj-13110	82	12	”	"	PUNCT
ecj-13110	82	13	answers	answer	NOUN
ecj-13110	82	14	were	be	AUX
ecj-13110	82	15	excluded	exclude	VERB
ecj-13110	82	16	from	from	ADP
ecj-13110	82	17	the	the	DET
ecj-13110	82	18	analysis	analysis	NOUN
ecj-13110	82	19	.	.	PUNCT
ecj-13110	83	1	those	those	PRON
ecj-13110	83	2	with	with	ADP
ecj-13110	83	3	3	3	NUM
ecj-13110	83	4	“	"	PUNCT
ecj-13110	83	5	yes	yes	INTJ
ecj-13110	83	6	”	"	PUNCT
ecj-13110	83	7	answers	answer	NOUN
ecj-13110	83	8	were	be	AUX
ecj-13110	83	9	considered	consider	VERB
ecj-13110	83	10	discrete	discrete	ADJ
ecj-13110	83	11	,	,	PUNCT
ecj-13110	83	12	while	while	SCONJ
ecj-13110	83	13	studies	study	NOUN
ecj-13110	83	14	with	with	ADP
ecj-13110	83	15	4	4	NUM
ecj-13110	83	16	“	"	PUNCT
ecj-13110	83	17	yes	yes	INTJ
ecj-13110	83	18	”	"	PUNCT
ecj-13110	83	19	answers	answer	NOUN
ecj-13110	83	20	were	be	AUX
ecj-13110	83	21	classified	classify	VERB
ecj-13110	83	22	as	as	ADP
ecj-13110	83	23	good	good	ADJ
ecj-13110	83	24	,	,	PUNCT
ecj-13110	83	25	and	and	CCONJ
ecj-13110	83	26	those	those	PRON
ecj-13110	83	27	with	with	ADP
ecj-13110	83	28	5	5	NUM
ecj-13110	83	29	“	"	PUNCT
ecj-13110	83	30	yes	yes	INTJ
ecj-13110	83	31	”	"	PUNCT
ecj-13110	83	32	answers	answer	NOUN
ecj-13110	83	33	were	be	AUX
ecj-13110	83	34	considered	consider	VERB
ecj-13110	83	35	to	to	PART
ecj-13110	83	36	be	be	AUX
ecj-13110	83	37	of	of	ADP
ecj-13110	83	38	excellent	excellent	ADJ
ecj-13110	83	39	quality	quality	NOUN
ecj-13110	83	40	(	(	PUNCT
ecj-13110	83	41	table	table	NOUN
ecj-13110	83	42	2	2	NUM
ecj-13110	83	43	)	)	PUNCT
ecj-13110	83	44	.	.	PUNCT
ecj-13110	84	1	two	two	NUM
ecj-13110	84	2	authors	author	NOUN
ecj-13110	84	3	independently	independently	ADV
ecj-13110	84	4	conducted	conduct	VERB
ecj-13110	84	5	the	the	DET
ecj-13110	84	6	critical	critical	ADJ
ecj-13110	84	7	quality	quality	NOUN
ecj-13110	84	8	assessment	assessment	NOUN
ecj-13110	84	9	.	.	PUNCT
ecj-13110	85	1	in	in	ADP
ecj-13110	85	2	cases	case	NOUN
ecj-13110	85	3	of	of	ADP
ecj-13110	85	4	disagreement	disagreement	NOUN
ecj-13110	85	5	on	on	ADP
ecj-13110	85	6	evaluations	evaluation	NOUN
ecj-13110	85	7	,	,	PUNCT
ecj-13110	85	8	a	a	DET
ecj-13110	85	9	further	further	ADJ
ecj-13110	85	10	comparison	comparison	NOUN
ecj-13110	85	11	was	be	AUX
ecj-13110	85	12	made	make	VERB
ecj-13110	85	13	to	to	PART
ecj-13110	85	14	reach	reach	VERB
ecj-13110	85	15	a	a	DET
ecj-13110	85	16	consensus	consensus	NOUN
ecj-13110	85	17	.	.	PUNCT
ecj-13110	86	1	results	result	VERB
ecj-13110	86	2	the	the	DET
ecj-13110	86	3	initial	initial	ADJ
ecj-13110	86	4	search	search	NOUN
ecj-13110	86	5	identified	identify	VERB
ecj-13110	86	6	111	111	NUM
ecj-13110	86	7	results	result	NOUN
ecj-13110	86	8	screened	screen	VERB
ecj-13110	86	9	by	by	ADP
ecj-13110	86	10	reviewing	review	VERB
ecj-13110	86	11	the	the	DET
ecj-13110	86	12	abstracts	abstract	NOUN
ecj-13110	86	13	.	.	PUNCT
ecj-13110	87	1	this	this	DET
ecj-13110	87	2	process	process	NOUN
ecj-13110	87	3	led	lead	VERB
ecj-13110	87	4	to	to	ADP
ecj-13110	87	5	the	the	DET
ecj-13110	87	6	exclusion	exclusion	NOUN
ecj-13110	87	7	of	of	ADP
ecj-13110	87	8	9	9	NUM
ecj-13110	87	9	studies	study	NOUN
ecj-13110	87	10	focused	focus	VERB
ecj-13110	87	11	on	on	ADP
ecj-13110	87	12	hiv	hiv	PROPN
ecj-13110	87	13	and/or	and/or	CCONJ
ecj-13110	87	14	overdose	overdose	ADJ
ecj-13110	87	15	prevention	prevention	NOUN
ecj-13110	87	16	.	.	PUNCT
ecj-13110	88	1	the	the	DET
ecj-13110	88	2	full	full	ADJ
ecj-13110	88	3	-	-	PUNCT
ecj-13110	88	4	text	text	NOUN
ecj-13110	88	5	review	review	NOUN
ecj-13110	88	6	of	of	ADP
ecj-13110	88	7	the	the	DET
ecj-13110	88	8	remaining	remain	VERB
ecj-13110	88	9	102	102	NUM
ecj-13110	88	10	articles	article	NOUN
ecj-13110	88	11	was	be	AUX
ecj-13110	88	12	then	then	ADV
ecj-13110	88	13	conducted	conduct	VERB
ecj-13110	88	14	.	.	PUNCT
ecj-13110	89	1	of	of	ADP
ecj-13110	89	2	these	these	PRON
ecj-13110	89	3	,	,	PUNCT
ecj-13110	89	4	24	24	NUM
ecj-13110	89	5	studies	study	NOUN
ecj-13110	89	6	related	relate	VERB
ecj-13110	89	7	to	to	ADP
ecj-13110	89	8	the	the	DET
ecj-13110	89	9	“	"	PUNCT
ecj-13110	89	10	take	take	VERB
ecj-13110	89	11	-	-	PUNCT
ecj-13110	89	12	home	home	NOUN
ecj-13110	89	13	”	"	PUNCT
ecj-13110	89	14	naloxone	naloxone	ADJ
ecj-13110	89	15	strategy	strategy	NOUN
ecj-13110	89	16	,	,	PUNCT
ecj-13110	89	17	involving	involve	VERB
ecj-13110	89	18	layperson	layperson	ADJ
ecj-13110	89	19	administration	administration	NOUN
ecj-13110	89	20	in	in	ADP
ecj-13110	89	21	case	case	NOUN
ecj-13110	89	22	of	of	ADP
ecj-13110	89	23	opioid	opioid	NOUN
ecj-13110	89	24	overdose	overdose	NOUN
ecj-13110	89	25	,	,	PUNCT
ecj-13110	89	26	were	be	AUX
ecj-13110	89	27	excluded	exclude	VERB
ecj-13110	89	28	.	.	PUNCT
ecj-13110	90	1	additionally	additionally	ADV
ecj-13110	90	2	,	,	PUNCT
ecj-13110	90	3	11	11	NUM
ecj-13110	90	4	studies	study	NOUN
ecj-13110	90	5	focusing	focus	VERB
ecj-13110	90	6	on	on	ADP
ecj-13110	90	7	hospital	hospital	NOUN
ecj-13110	90	8	-	-	PUNCT
ecj-13110	90	9	based	base	VERB
ecj-13110	90	10	overdoses	overdose	NOUN
ecj-13110	90	11	,	,	PUNCT
ecj-13110	90	12	38	38	NUM
ecj-13110	90	13	discussing	discuss	VERB
ecj-13110	90	14	chronic	chronic	ADJ
ecj-13110	90	15	opioid	opioid	NOUN
ecj-13110	90	16	use	use	VERB
ecj-13110	90	17	disorder	disorder	NOUN
ecj-13110	90	18	,	,	PUNCT
ecj-13110	90	19	4	4	NUM
ecj-13110	90	20	addressing	address	VERB
ecj-13110	90	21	the	the	DET
ecj-13110	90	22	medical	medical	ADJ
ecj-13110	90	23	use	use	NOUN
ecj-13110	90	24	of	of	ADP
ecj-13110	90	25	opioids	opioid	NOUN
ecj-13110	90	26	for	for	ADP
ecj-13110	90	27	other	other	ADJ
ecj-13110	90	28	conditions	condition	NOUN
ecj-13110	90	29	,	,	PUNCT
ecj-13110	90	30	4	4	NUM
ecj-13110	90	31	on	on	ADP
ecj-13110	90	32	the	the	DET
ecj-13110	90	33	economic	economic	ADJ
ecj-13110	90	34	impact	impact	NOUN
ecj-13110	90	35	of	of	ADP
ecj-13110	90	36	the	the	DET
ecj-13110	90	37	opioid	opioid	ADJ
ecj-13110	90	38	epidemic	epidemic	NOUN
ecj-13110	90	39	,	,	PUNCT
ecj-13110	90	40	and	and	CCONJ
ecj-13110	90	41	8	8	NUM
ecj-13110	90	42	discussing	discuss	VERB
ecj-13110	90	43	opioid	opioid	ADJ
ecj-13110	90	44	overdose	overdose	ADJ
ecj-13110	90	45	monitoring	monitoring	NOUN
ecj-13110	90	46	techniques	technique	NOUN
ecj-13110	90	47	were	be	AUX
ecj-13110	90	48	excluded	exclude	VERB
ecj-13110	90	49	,	,	PUNCT
ecj-13110	90	50	along	along	ADP
ecj-13110	90	51	with	with	ADP
ecj-13110	90	52	other	other	ADJ
ecj-13110	90	53	studies	study	NOUN
ecj-13110	90	54	addressing	address	VERB
ecj-13110	90	55	topics	topic	NOUN
ecj-13110	90	56	unrelated	unrelated	ADJ
ecj-13110	90	57	to	to	ADP
ecj-13110	90	58	the	the	DET
ecj-13110	90	59	research	research	NOUN
ecj-13110	90	60	question	question	NOUN
ecj-13110	90	61	.	.	PUNCT
ecj-13110	91	1	this	this	DET
ecj-13110	91	2	process	process	NOUN
ecj-13110	91	3	left	leave	VERB
ecj-13110	91	4	13	13	NUM
ecj-13110	91	5	studies	study	NOUN
ecj-13110	91	6	for	for	ADP
ecj-13110	91	7	more	more	ADV
ecj-13110	91	8	detailed	detailed	ADJ
ecj-13110	91	9	analysis	analysis	NOUN
ecj-13110	91	10	.	.	PUNCT
ecj-13110	92	1	the	the	DET
ecj-13110	92	2	populations	population	NOUN
ecj-13110	92	3	,	,	PUNCT
ecj-13110	92	4	research	research	NOUN
ecj-13110	92	5	questions	question	NOUN
ecj-13110	92	6	,	,	PUNCT
ecj-13110	92	7	and	and	CCONJ
ecj-13110	92	8	treatment	treatment	NOUN
ecj-13110	92	9	techniques	technique	NOUN
ecj-13110	92	10	for	for	ADP
ecj-13110	92	11	opioid	opioid	ADJ
ecj-13110	92	12	overdose	overdose	NOUN
ecj-13110	92	13	were	be	AUX
ecj-13110	92	14	compared	compare	VERB
ecj-13110	92	15	to	to	PART
ecj-13110	92	16	identify	identify	VERB
ecj-13110	92	17	any	any	DET
ecj-13110	92	18	discrepancies	discrepancy	NOUN
ecj-13110	92	19	.	.	PUNCT
ecj-13110	93	1	further	further	ADJ
ecj-13110	93	2	exclusions	exclusion	NOUN
ecj-13110	93	3	resulted	result	VERB
ecj-13110	93	4	in	in	ADP
ecj-13110	93	5	the	the	DET
ecj-13110	93	6	removal	removal	NOUN
ecj-13110	93	7	of	of	ADP
ecj-13110	93	8	7	7	NUM
ecj-13110	93	9	studies	study	NOUN
ecj-13110	93	10	that	that	PRON
ecj-13110	93	11	were	be	AUX
ecj-13110	93	12	not	not	PART
ecj-13110	93	13	directly	directly	ADV
ecj-13110	93	14	relevant	relevant	ADJ
ecj-13110	93	15	to	to	ADP
ecj-13110	93	16	the	the	DET
ecj-13110	93	17	research	research	NOUN
ecj-13110	93	18	question	question	NOUN
ecj-13110	93	19	.	.	PUNCT
ecj-13110	94	1	specifically	specifically	ADV
ecj-13110	94	2	,	,	PUNCT
ecj-13110	94	3	2	2	NUM
ecj-13110	94	4	studies	study	NOUN
ecj-13110	94	5	compared	compare	VERB
ecj-13110	94	6	different	different	ADJ
ecj-13110	94	7	formulations	formulation	NOUN
ecj-13110	94	8	of	of	ADP
ecj-13110	94	9	intranasal	intranasal	ADJ
ecj-13110	94	10	naloxone	naloxone	NOUN
ecj-13110	94	11	,	,	PUNCT
ecj-13110	94	12	1	1	NUM
ecj-13110	94	13	investigated	investigate	VERB
ecj-13110	94	14	opioid	opioid	ADJ
ecj-13110	94	15	receptor	receptor	NOUN
ecj-13110	94	16	occupancy	occupancy	NOUN
ecj-13110	94	17	by	by	ADP
ecj-13110	94	18	naloxone	naloxone	NOUN
ecj-13110	94	19	,	,	PUNCT
ecj-13110	94	20	2	2	NUM
ecj-13110	94	21	examined	examine	VERB
ecj-13110	94	22	the	the	DET
ecj-13110	94	23	bioavailability	bioavailability	NOUN
ecj-13110	94	24	of	of	ADP
ecj-13110	94	25	a	a	DET
ecj-13110	94	26	2	2	NUM
ecj-13110	94	27	mg	mg	PROPN
ecj-13110	94	28	naloxone	naloxone	NOUN
ecj-13110	94	29	spray	spray	NOUN
ecj-13110	94	30	,	,	PUNCT
ecj-13110	94	31	and	and	CCONJ
ecj-13110	94	32	the	the	DET
ecj-13110	94	33	other	other	ADJ
ecj-13110	94	34	studies	study	NOUN
ecj-13110	94	35	focused	focus	VERB
ecj-13110	94	36	on	on	ADP
ecj-13110	94	37	the	the	DET
ecj-13110	94	38	adverse	adverse	ADJ
ecj-13110	94	39	effects	effect	NOUN
ecj-13110	94	40	of	of	ADP
ecj-13110	94	41	naloxone	naloxone	ADJ
ecj-13110	94	42	post	post	ADJ
ecj-13110	94	43	-	-	ADJ
ecj-13110	94	44	overdose	overdose	ADJ
ecj-13110	94	45	treatment	treatment	NOUN
ecj-13110	94	46	,	,	PUNCT
ecj-13110	94	47	regardless	regardless	ADV
ecj-13110	94	48	of	of	ADP
ecj-13110	94	49	formulation	formulation	NOUN
ecj-13110	94	50	.	.	PUNCT
ecj-13110	95	1	ultimately	ultimately	ADV
ecj-13110	95	2	,	,	PUNCT
ecj-13110	95	3	five	five	NUM
ecj-13110	95	4	studies	study	NOUN
ecj-13110	95	5	met	meet	VERB
ecj-13110	95	6	the	the	DET
ecj-13110	95	7	eligibility	eligibility	NOUN
ecj-13110	95	8	criteria	criterion	NOUN
ecj-13110	95	9	and	and	CCONJ
ecj-13110	95	10	were	be	AUX
ecj-13110	95	11	included	include	VERB
ecj-13110	95	12	in	in	ADP
ecj-13110	95	13	the	the	DET
ecj-13110	95	14	review	review	NOUN
ecj-13110	95	15	(	(	PUNCT
ecj-13110	95	16	figure	figure	NOUN
ecj-13110	95	17	1	1	NUM
ecj-13110	95	18	)	)	PUNCT
ecj-13110	95	19	.	.	PUNCT
ecj-13110	96	1	the	the	DET
ecj-13110	96	2	quality	quality	NOUN
ecj-13110	96	3	assessment	assessment	NOUN
ecj-13110	96	4	,	,	PUNCT
ecj-13110	96	5	based	base	VERB
ecj-13110	96	6	on	on	ADP
ecj-13110	96	7	the	the	DET
ecj-13110	96	8	dixon	dixon	NOUN
ecj-13110	96	9	-	-	PUNCT
ecj-13110	96	10	woods	wood	NOUN
ecj-13110	96	11	checklist	checklist	NOUN
ecj-13110	96	12	,	,	PUNCT
ecj-13110	96	13	revealed	reveal	VERB
ecj-13110	96	14	that	that	SCONJ
ecj-13110	96	15	the	the	DET
ecj-13110	96	16	included	include	VERB
ecj-13110	96	17	studies	study	NOUN
ecj-13110	96	18	achieved	achieve	VERB
ecj-13110	96	19	a	a	DET
ecj-13110	96	20	minimum	minimum	NOUN
ecj-13110	96	21	rating	rating	NOUN
ecj-13110	96	22	of	of	ADP
ecj-13110	96	23	review	review	NOUN
ecj-13110	96	24	figure	figure	NOUN
ecj-13110	96	25	1	1	NUM
ecj-13110	96	26	.	.	PUNCT
ecj-13110	97	1	summary	summary	NOUN
ecj-13110	97	2	of	of	ADP
ecj-13110	97	3	the	the	DET
ecj-13110	97	4	study	study	NOUN
ecj-13110	97	5	selection	selection	NOUN
ecj-13110	97	6	.	.	PUNCT
ecj-13110	98	1	[	[	X
ecj-13110	98	2	emergency	emergency	NOUN
ecj-13110	98	3	care	care	NOUN
ecj-13110	98	4	journal	journal	NOUN
ecj-13110	98	5	2025	2025	NUM
ecj-13110	98	6	;	;	PUNCT
ecj-13110	98	7	21:13110	21:13110	NUM
ecj-13110	98	8	]	]	X
ecj-13110	98	9	[	[	X
ecj-13110	98	10	page	page	NOUN
ecj-13110	98	11	43	43	NUM
ecj-13110	98	12	]	]	PUNCT
ecj-13110	98	13	“	"	PUNCT
ecj-13110	98	14	discrete	discrete	NOUN
ecj-13110	98	15	”	"	PUNCT
ecj-13110	98	16	and	and	CCONJ
ecj-13110	98	17	were	be	AUX
ecj-13110	98	18	considered	consider	VERB
ecj-13110	98	19	sufficiently	sufficiently	ADV
ecj-13110	98	20	robust	robust	ADJ
ecj-13110	98	21	for	for	ADP
ecj-13110	98	22	inclusion	inclusion	NOUN
ecj-13110	98	23	(	(	PUNCT
ecj-13110	98	24	table	table	NOUN
ecj-13110	98	25	2	2	NUM
ecj-13110	98	26	)	)	PUNCT
ecj-13110	98	27	.	.	PUNCT
ecj-13110	99	1	the	the	DET
ecj-13110	99	2	studies	study	NOUN
ecj-13110	99	3	included	include	VERB
ecj-13110	99	4	in	in	ADP
ecj-13110	99	5	this	this	DET
ecj-13110	99	6	review	review	NOUN
ecj-13110	99	7	involved	involve	VERB
ecj-13110	99	8	different	different	ADJ
ecj-13110	99	9	populations	population	NOUN
ecj-13110	99	10	,	,	PUNCT
ecj-13110	99	11	from	from	ADP
ecj-13110	99	12	healthy	healthy	ADJ
ecj-13110	99	13	volunteers	volunteer	NOUN
ecj-13110	99	14	with	with	ADP
ecj-13110	99	15	no	no	DET
ecj-13110	99	16	history	history	NOUN
ecj-13110	99	17	of	of	ADP
ecj-13110	99	18	drug	drug	NOUN
ecj-13110	99	19	use	use	NOUN
ecj-13110	99	20	to	to	ADP
ecj-13110	99	21	patients	patient	NOUN
ecj-13110	99	22	with	with	ADP
ecj-13110	99	23	active	active	ADJ
ecj-13110	99	24	drug	drug	NOUN
ecj-13110	99	25	use	use	NOUN
ecj-13110	99	26	.	.	PUNCT
ecj-13110	100	1	these	these	DET
ecj-13110	100	2	differences	difference	NOUN
ecj-13110	100	3	in	in	ADP
ecj-13110	100	4	participant	participant	ADJ
ecj-13110	100	5	characteristics	characteristic	NOUN
ecj-13110	100	6	,	,	PUNCT
ecj-13110	100	7	including	include	VERB
ecj-13110	100	8	their	their	PRON
ecj-13110	100	9	previous	previous	ADJ
ecj-13110	100	10	exposure	exposure	NOUN
ecj-13110	100	11	to	to	ADP
ecj-13110	100	12	opioids	opioid	NOUN
ecj-13110	100	13	or	or	CCONJ
ecj-13110	100	14	other	other	ADJ
ecj-13110	100	15	substances	substance	NOUN
ecj-13110	100	16	,	,	PUNCT
ecj-13110	100	17	influence	influence	VERB
ecj-13110	100	18	the	the	DET
ecj-13110	100	19	outcomes	outcome	NOUN
ecj-13110	100	20	and	and	CCONJ
ecj-13110	100	21	should	should	AUX
ecj-13110	100	22	be	be	AUX
ecj-13110	100	23	considered	consider	VERB
ecj-13110	100	24	when	when	SCONJ
ecj-13110	100	25	interpreting	interpret	VERB
ecj-13110	100	26	the	the	DET
ecj-13110	100	27	results	result	NOUN
ecj-13110	100	28	of	of	ADP
ecj-13110	100	29	the	the	DET
ecj-13110	100	30	comparison	comparison	NOUN
ecj-13110	100	31	between	between	ADP
ecj-13110	100	32	different	different	ADJ
ecj-13110	100	33	naloxone	naloxone	ADJ
ecj-13110	100	34	formulations	formulation	NOUN
ecj-13110	100	35	.	.	PUNCT
ecj-13110	101	1	a	a	DET
ecj-13110	101	2	summary	summary	NOUN
ecj-13110	101	3	of	of	ADP
ecj-13110	101	4	the	the	DET
ecj-13110	101	5	study	study	NOUN
ecj-13110	101	6	characteristics	characteristic	NOUN
ecj-13110	101	7	,	,	PUNCT
ecj-13110	101	8	including	include	VERB
ecj-13110	101	9	objectives	objective	NOUN
ecj-13110	101	10	and	and	CCONJ
ecj-13110	101	11	key	key	ADJ
ecj-13110	101	12	findings	finding	NOUN
ecj-13110	101	13	,	,	PUNCT
ecj-13110	101	14	is	be	AUX
ecj-13110	101	15	provided	provide	VERB
ecj-13110	101	16	in	in	ADP
ecj-13110	101	17	supplementary	supplementary	ADJ
ecj-13110	101	18	materials	material	NOUN
ecj-13110	101	19	table	table	NOUN
ecj-13110	101	20	1	1	NUM
ecj-13110	101	21	.	.	PUNCT
ecj-13110	102	1	the	the	DET
ecj-13110	102	2	studies	study	NOUN
ecj-13110	102	3	can	can	AUX
ecj-13110	102	4	be	be	AUX
ecj-13110	102	5	divided	divide	VERB
ecj-13110	102	6	into	into	ADP
ecj-13110	102	7	“	"	PUNCT
ecj-13110	102	8	pre	pre	ADJ
ecj-13110	102	9	-	-	NOUN
ecj-13110	102	10	hospital	hospital	ADJ
ecj-13110	102	11	”	"	PUNCT
ecj-13110	102	12	and	and	CCONJ
ecj-13110	102	13	“	"	PUNCT
ecj-13110	102	14	other	other	ADJ
ecj-13110	102	15	settings	setting	NOUN
ecj-13110	102	16	.	.	PUNCT
ecj-13110	102	17	”	"	PUNCT
ecj-13110	103	1	the	the	DET
ecj-13110	103	2	studies	study	NOUN
ecj-13110	103	3	by	by	ADP
ecj-13110	103	4	skulberg	skulberg	PROPN
ecj-13110	103	5	et	et	PROPN
ecj-13110	103	6	al	al	PROPN
ecj-13110	103	7	.	.	PUNCT
ecj-13110	104	1	(	(	PUNCT
ecj-13110	104	2	2022)13	2022)13	NUM
ecj-13110	104	3	and	and	CCONJ
ecj-13110	104	4	dietze	dietze	PROPN
ecj-13110	104	5	et	et	PROPN
ecj-13110	104	6	al.14	al.14	PROPN
ecj-13110	104	7	were	be	AUX
ecj-13110	104	8	conducted	conduct	VERB
ecj-13110	104	9	in	in	ADP
ecj-13110	104	10	prehospital	prehospital	ADJ
ecj-13110	104	11	settings	setting	NOUN
ecj-13110	104	12	,	,	PUNCT
ecj-13110	104	13	with	with	ADP
ecj-13110	104	14	skulberg	skulberg	ADJ
ecj-13110	104	15	taking	take	VERB
ecj-13110	104	16	place	place	NOUN
ecj-13110	104	17	in	in	ADP
ecj-13110	104	18	an	an	DET
ecj-13110	104	19	ambulance	ambulance	NOUN
ecj-13110	104	20	during	during	ADP
ecj-13110	104	21	opioid	opioid	ADJ
ecj-13110	104	22	overdose	overdose	ADJ
ecj-13110	104	23	emergencies	emergency	NOUN
ecj-13110	104	24	and	and	CCONJ
ecj-13110	104	25	dietze	dietze	VERB
ecj-13110	104	26	et	et	PROPN
ecj-13110	104	27	al	al	PROPN
ecj-13110	104	28	.	.	PROPN
ecj-13110	104	29	carried	carry	VERB
ecj-13110	104	30	out	out	ADP
ecj-13110	104	31	in	in	ADP
ecj-13110	104	32	a	a	DET
ecj-13110	104	33	community	community	NOUN
ecj-13110	104	34	setting	set	VERB
ecj-13110	104	35	involving	involve	VERB
ecj-13110	104	36	individuals	individual	NOUN
ecj-13110	104	37	with	with	ADP
ecj-13110	104	38	a	a	DET
ecj-13110	104	39	history	history	NOUN
ecj-13110	104	40	of	of	ADP
ecj-13110	104	41	opioid	opioid	ADJ
ecj-13110	104	42	use	use	NOUN
ecj-13110	104	43	.	.	PUNCT
ecj-13110	105	1	the	the	DET
ecj-13110	105	2	studies	study	NOUN
ecj-13110	105	3	by	by	ADP
ecj-13110	105	4	skulberg	skulberg	PROPN
ecj-13110	105	5	et	et	PROPN
ecj-13110	105	6	al	al	PROPN
ecj-13110	105	7	.	.	PUNCT
ecj-13110	106	1	(	(	PUNCT
ecj-13110	106	2	2019),15	2019),15	NUM
ecj-13110	106	3	skulberg	skulberg	PROPN
ecj-13110	106	4	et	et	PROPN
ecj-13110	106	5	al	al	PROPN
ecj-13110	106	6	.	.	PUNCT
ecj-13110	107	1	(	(	PUNCT
ecj-13110	107	2	2018),16	2018),16	NUM
ecj-13110	107	3	and	and	CCONJ
ecj-13110	107	4	mcdonald	mcdonald	PROPN
ecj-13110	107	5	et	et	PROPN
ecj-13110	107	6	al.17	al.17	PROPN
ecj-13110	107	7	were	be	AUX
ecj-13110	107	8	conducted	conduct	VERB
ecj-13110	107	9	in	in	ADP
ecj-13110	107	10	controlled	control	VERB
ecj-13110	107	11	clinical	clinical	ADJ
ecj-13110	107	12	settings	setting	NOUN
ecj-13110	107	13	with	with	ADP
ecj-13110	107	14	healthy	healthy	ADJ
ecj-13110	107	15	volunteers	volunteer	NOUN
ecj-13110	107	16	.	.	PUNCT
ecj-13110	108	1	while	while	SCONJ
ecj-13110	108	2	most	most	ADJ
ecj-13110	108	3	studies	study	NOUN
ecj-13110	108	4	focused	focus	VERB
ecj-13110	108	5	on	on	ADP
ecj-13110	108	6	prehospital	prehospital	ADJ
ecj-13110	108	7	environments	environment	NOUN
ecj-13110	108	8	,	,	PUNCT
ecj-13110	108	9	additional	additional	ADJ
ecj-13110	108	10	data	datum	NOUN
ecj-13110	108	11	from	from	ADP
ecj-13110	108	12	other	other	ADJ
ecj-13110	108	13	healthcare	healthcare	NOUN
ecj-13110	108	14	settings	setting	NOUN
ecj-13110	108	15	were	be	AUX
ecj-13110	108	16	also	also	ADV
ecj-13110	108	17	incorporated	incorporate	VERB
ecj-13110	108	18	to	to	PART
ecj-13110	108	19	address	address	VERB
ecj-13110	108	20	gaps	gap	NOUN
ecj-13110	108	21	in	in	ADP
ecj-13110	108	22	pre	pre	ADJ
ecj-13110	108	23	-	-	ADJ
ecj-13110	108	24	hospital	hospital	ADJ
ecj-13110	108	25	-	-	PUNCT
ecj-13110	108	26	specific	specific	ADJ
ecj-13110	108	27	evidence	evidence	NOUN
ecj-13110	108	28	.	.	PUNCT
ecj-13110	109	1	in	in	ADP
ecj-13110	109	2	the	the	DET
ecj-13110	109	3	study	study	NOUN
ecj-13110	109	4	by	by	ADP
ecj-13110	109	5	mcdonald	mcdonald	PROPN
ecj-13110	109	6	et	et	PROPN
ecj-13110	109	7	al	al	PROPN
ecj-13110	109	8	.	.	PROPN
ecj-13110	109	9	,17	,17	PUNCT
ecj-13110	109	10	three	three	NUM
ecj-13110	109	11	main	main	ADJ
ecj-13110	109	12	objectives	objective	NOUN
ecj-13110	109	13	were	be	AUX
ecj-13110	109	14	pursued	pursue	VERB
ecj-13110	109	15	:	:	PUNCT
ecj-13110	109	16	i	i	X
ecj-13110	109	17	)	)	PUNCT
ecj-13110	109	18	to	to	PART
ecj-13110	109	19	describe	describe	VERB
ecj-13110	109	20	the	the	DET
ecj-13110	109	21	pharmacokinetic	pharmacokinetic	ADJ
ecj-13110	109	22	profile	profile	NOUN
ecj-13110	109	23	of	of	ADP
ecj-13110	109	24	intranasal	intranasal	ADJ
ecj-13110	109	25	naloxone	naloxone	NOUN
ecj-13110	109	26	;	;	PUNCT
ecj-13110	109	27	ii	ii	X
ecj-13110	109	28	)	)	PUNCT
ecj-13110	109	29	to	to	PART
ecj-13110	109	30	compare	compare	VERB
ecj-13110	109	31	early	early	ADJ
ecj-13110	109	32	systemic	systemic	ADJ
ecj-13110	109	33	exposure	exposure	NOUN
ecj-13110	109	34	between	between	ADP
ecj-13110	109	35	intranasal	intranasal	NOUN
ecj-13110	109	36	and	and	CCONJ
ecj-13110	109	37	intramuscular	intramuscular	ADJ
ecj-13110	109	38	naloxone	naloxone	NOUN
ecj-13110	109	39	;	;	PUNCT
ecj-13110	109	40	and	and	CCONJ
ecj-13110	109	41	iii	iii	X
ecj-13110	109	42	)	)	PUNCT
ecj-13110	109	43	to	to	PART
ecj-13110	109	44	estimate	estimate	VERB
ecj-13110	109	45	the	the	DET
ecj-13110	109	46	bioavailability	bioavailability	NOUN
ecj-13110	109	47	of	of	ADP
ecj-13110	109	48	intranasal	intranasal	ADJ
ecj-13110	109	49	naloxone	naloxone	NOUN
ecj-13110	109	50	.	.	PUNCT
ecj-13110	110	1	the	the	DET
ecj-13110	110	2	pharmacokinetic	pharmacokinetic	ADJ
ecj-13110	110	3	parameters	parameter	NOUN
ecj-13110	110	4	revealed	reveal	VERB
ecj-13110	110	5	that	that	SCONJ
ecj-13110	110	6	intravenous	intravenous	ADJ
ecj-13110	110	7	naloxone	naloxone	NOUN
ecj-13110	110	8	at	at	ADP
ecj-13110	110	9	0.4	0.4	NUM
ecj-13110	110	10	mg	mg	PROPN
ecj-13110	110	11	showed	show	VERB
ecj-13110	110	12	a	a	DET
ecj-13110	110	13	rapid	rapid	ADJ
ecj-13110	110	14	increase	increase	NOUN
ecj-13110	110	15	in	in	ADP
ecj-13110	110	16	plasma	plasma	NOUN
ecj-13110	110	17	concentration	concentration	NOUN
ecj-13110	110	18	,	,	PUNCT
ecj-13110	110	19	peaking	peak	VERB
ecj-13110	110	20	at	at	ADP
ecj-13110	110	21	5.94	5.94	NUM
ecj-13110	110	22	ng	ng	NOUN
ecj-13110	110	23	/	/	SYM
ecj-13110	110	24	ml	ml	NOUN
ecj-13110	110	25	within	within	ADP
ecj-13110	110	26	2	2	NUM
ecj-13110	110	27	minutes	minute	NOUN
ecj-13110	110	28	,	,	PUNCT
ecj-13110	110	29	followed	follow	VERB
ecj-13110	110	30	by	by	ADP
ecj-13110	110	31	a	a	DET
ecj-13110	110	32	quick	quick	ADJ
ecj-13110	110	33	decline	decline	NOUN
ecj-13110	110	34	.	.	PUNCT
ecj-13110	111	1	in	in	ADP
ecj-13110	111	2	contrast	contrast	NOUN
ecj-13110	111	3	,	,	PUNCT
ecj-13110	111	4	intramuscular	intramuscular	ADJ
ecj-13110	111	5	naloxone	naloxone	NOUN
ecj-13110	111	6	at	at	ADP
ecj-13110	111	7	0.4	0.4	NUM
ecj-13110	111	8	mg	mg	PROPN
ecj-13110	111	9	had	have	VERB
ecj-13110	111	10	a	a	DET
ecj-13110	111	11	slower	slow	ADJ
ecj-13110	111	12	absorption	absorption	NOUN
ecj-13110	111	13	rate	rate	NOUN
ecj-13110	111	14	,	,	PUNCT
ecj-13110	111	15	with	with	ADP
ecj-13110	111	16	a	a	DET
ecj-13110	111	17	peak	peak	NOUN
ecj-13110	111	18	concentration	concentration	NOUN
ecj-13110	111	19	of	of	ADP
ecj-13110	111	20	1.27	1.27	NUM
ecj-13110	111	21	ng	ng	NOUN
ecj-13110	111	22	/	/	SYM
ecj-13110	111	23	ml	ml	NOUN
ecj-13110	111	24	at	at	ADP
ecj-13110	111	25	10	10	NUM
ecj-13110	111	26	minutes	minute	NOUN
ecj-13110	111	27	and	and	CCONJ
ecj-13110	111	28	a	a	DET
ecj-13110	111	29	more	more	ADV
ecj-13110	111	30	gradual	gradual	ADJ
ecj-13110	111	31	decline	decline	NOUN
ecj-13110	111	32	.	.	PUNCT
ecj-13110	112	1	intranasal	intranasal	ADJ
ecj-13110	112	2	naloxone	naloxone	NOUN
ecj-13110	112	3	at	at	ADP
ecj-13110	112	4	1	1	NUM
ecj-13110	112	5	mg	mg	NOUN
ecj-13110	112	6	,	,	PUNCT
ecj-13110	112	7	2	2	NUM
ecj-13110	112	8	mg	mg	NOUN
ecj-13110	112	9	,	,	PUNCT
ecj-13110	112	10	and	and	CCONJ
ecj-13110	112	11	4	4	NUM
ecj-13110	112	12	mg	mg	NOUN
ecj-13110	112	13	achieved	achieve	VERB
ecj-13110	112	14	peak	peak	NOUN
ecj-13110	112	15	plasma	plasma	NOUN
ecj-13110	112	16	concentrations	concentration	NOUN
ecj-13110	112	17	of	of	ADP
ecj-13110	112	18	approximately	approximately	ADV
ecj-13110	112	19	0.95	0.95	NUM
ecj-13110	112	20	ng	ng	PROPN
ecj-13110	112	21	/	/	SYM
ecj-13110	112	22	ml	ml	PROPN
ecj-13110	112	23	,	,	PUNCT
ecj-13110	112	24	1.72	1.72	NUM
ecj-13110	112	25	ng	ng	PROPN
ecj-13110	112	26	/	/	SYM
ecj-13110	112	27	ml	ml	PROPN
ecj-13110	112	28	,	,	PUNCT
ecj-13110	112	29	and	and	CCONJ
ecj-13110	112	30	3.5	3.5	NUM
ecj-13110	112	31	ng	ng	NOUN
ecj-13110	112	32	/	/	SYM
ecj-13110	112	33	ml	ml	PROPN
ecj-13110	112	34	,	,	PUNCT
ecj-13110	112	35	respectively	respectively	ADV
ecj-13110	112	36	,	,	PUNCT
ecj-13110	112	37	within	within	ADP
ecj-13110	112	38	15	15	NUM
ecj-13110	112	39	-	-	SYM
ecj-13110	112	40	30	30	NUM
ecj-13110	112	41	minutes	minute	NOUN
ecj-13110	112	42	,	,	PUNCT
ecj-13110	112	43	consistently	consistently	ADV
ecj-13110	112	44	surpassing	surpass	VERB
ecj-13110	112	45	those	those	PRON
ecj-13110	112	46	achieved	achieve	VERB
ecj-13110	112	47	with	with	ADP
ecj-13110	112	48	intramuscular	intramuscular	ADJ
ecj-13110	112	49	naloxone	naloxone	NOUN
ecj-13110	112	50	in	in	ADP
ecj-13110	112	51	terms	term	NOUN
ecj-13110	112	52	of	of	ADP
ecj-13110	112	53	total	total	ADJ
ecj-13110	112	54	exposure	exposure	NOUN
ecj-13110	112	55	.	.	PUNCT
ecj-13110	113	1	among	among	ADP
ecj-13110	113	2	the	the	DET
ecj-13110	113	3	intranasal	intranasal	ADJ
ecj-13110	113	4	doses	dose	NOUN
ecj-13110	113	5	,	,	PUNCT
ecj-13110	113	6	the	the	DET
ecj-13110	113	7	2	2	NUM
ecj-13110	113	8	mg	mg	NOUN
ecj-13110	113	9	spray	spray	VERB
ecj-13110	113	10	closely	closely	ADV
ecj-13110	113	11	mirrored	mirror	VERB
ecj-13110	113	12	the	the	DET
ecj-13110	113	13	intramuscular	intramuscular	ADJ
ecj-13110	113	14	naloxone	naloxone	ADJ
ecj-13110	113	15	curve	curve	NOUN
ecj-13110	113	16	within	within	ADP
ecj-13110	113	17	the	the	DET
ecj-13110	113	18	first	first	ADJ
ecj-13110	113	19	10	10	NUM
ecj-13110	113	20	minutes	minute	NOUN
ecj-13110	113	21	post	post	ADJ
ecj-13110	113	22	-	-	ADJ
ecj-13110	113	23	dose	dose	ADJ
ecj-13110	113	24	and	and	CCONJ
ecj-13110	113	25	maintained	maintain	VERB
ecj-13110	113	26	higher	high	ADJ
ecj-13110	113	27	plasma	plasma	NOUN
ecj-13110	113	28	levels	level	NOUN
ecj-13110	113	29	for	for	ADP
ecj-13110	113	30	two	two	NUM
ecj-13110	113	31	hours	hour	NOUN
ecj-13110	113	32	.	.	PUNCT
ecj-13110	114	1	the	the	DET
ecj-13110	114	2	bioavailability	bioavailability	NOUN
ecj-13110	114	3	of	of	ADP
ecj-13110	114	4	intranasal	intranasal	ADJ
ecj-13110	114	5	naloxone	naloxone	NOUN
ecj-13110	114	6	was	be	AUX
ecj-13110	114	7	estimated	estimate	VERB
ecj-13110	114	8	as	as	ADP
ecj-13110	114	9	50.2	50.2	NUM
ecj-13110	114	10	%	%	NOUN
ecj-13110	114	11	for	for	ADP
ecj-13110	114	12	1	1	NUM
ecj-13110	114	13	mg	mg	PROPN
ecj-13110	114	14	,	,	PUNCT
ecj-13110	114	15	46.8	46.8	NUM
ecj-13110	114	16	%	%	NOUN
ecj-13110	114	17	for	for	ADP
ecj-13110	114	18	2	2	NUM
ecj-13110	114	19	mg	mg	NOUN
ecj-13110	114	20	,	,	PUNCT
ecj-13110	114	21	and	and	CCONJ
ecj-13110	114	22	48.1	48.1	NUM
ecj-13110	114	23	%	%	NOUN
ecj-13110	114	24	for	for	ADP
ecj-13110	114	25	4	4	NUM
ecj-13110	114	26	mg	mg	NOUN
ecj-13110	114	27	,	,	PUNCT
ecj-13110	114	28	relative	relative	ADJ
ecj-13110	114	29	to	to	ADP
ecj-13110	114	30	intravenous	intravenous	ADJ
ecj-13110	114	31	administration	administration	NOUN
ecj-13110	114	32	.	.	PUNCT
ecj-13110	115	1	relative	relative	ADJ
ecj-13110	115	2	bioavailability	bioavailability	NOUN
ecj-13110	115	3	compared	compare	VERB
ecj-13110	115	4	to	to	ADP
ecj-13110	115	5	intramuscular	intramuscular	ADJ
ecj-13110	115	6	naloxone	naloxone	NOUN
ecj-13110	115	7	was	be	AUX
ecj-13110	115	8	50.8	50.8	NUM
ecj-13110	115	9	%	%	NOUN
ecj-13110	115	10	for	for	ADP
ecj-13110	115	11	1	1	NUM
ecj-13110	115	12	mg	mg	PROPN
ecj-13110	115	13	,	,	PUNCT
ecj-13110	115	14	47.1	47.1	NUM
ecj-13110	115	15	%	%	NOUN
ecj-13110	115	16	for	for	ADP
ecj-13110	115	17	2	2	NUM
ecj-13110	115	18	mg	mg	NOUN
ecj-13110	115	19	,	,	PUNCT
ecj-13110	115	20	and	and	CCONJ
ecj-13110	115	21	48.3	48.3	NUM
ecj-13110	115	22	%	%	NOUN
ecj-13110	115	23	for	for	ADP
ecj-13110	115	24	4	4	NUM
ecj-13110	115	25	mg	mg	NOUN
ecj-13110	115	26	.	.	PUNCT
ecj-13110	116	1	in	in	ADP
ecj-13110	116	2	the	the	DET
ecj-13110	116	3	study	study	NOUN
ecj-13110	116	4	by	by	ADP
ecj-13110	116	5	skulberg	skulberg	PROPN
ecj-13110	116	6	et	et	PROPN
ecj-13110	116	7	al	al	PROPN
ecj-13110	116	8	.	.	PUNCT
ecj-13110	117	1	(	(	PUNCT
ecj-13110	117	2	2018),16	2018),16	NUM
ecj-13110	117	3	the	the	DET
ecj-13110	117	4	primary	primary	ADJ
ecj-13110	117	5	endpoint	endpoint	NOUN
ecj-13110	117	6	was	be	AUX
ecj-13110	117	7	to	to	PART
ecj-13110	117	8	evaluate	evaluate	VERB
ecj-13110	117	9	the	the	DET
ecj-13110	117	10	pharmacodynamic	pharmacodynamic	ADJ
ecj-13110	117	11	profile	profile	NOUN
ecj-13110	117	12	of	of	ADP
ecj-13110	117	13	intranasal	intranasal	NOUN
ecj-13110	117	14	versus	versus	ADP
ecj-13110	117	15	intramuscular	intramuscular	ADJ
ecj-13110	117	16	naloxone	naloxone	NOUN
ecj-13110	117	17	.	.	PUNCT
ecj-13110	118	1	twelve	twelve	NUM
ecj-13110	118	2	healthy	healthy	ADJ
ecj-13110	118	3	volunteers	volunteer	NOUN
ecj-13110	118	4	received	receive	VERB
ecj-13110	118	5	remifentanil	remifentanil	NOUN
ecj-13110	118	6	and	and	CCONJ
ecj-13110	118	7	were	be	AUX
ecj-13110	118	8	subsequently	subsequently	ADV
ecj-13110	118	9	assessed	assess	VERB
ecj-13110	118	10	for	for	ADP
ecj-13110	118	11	changes	change	NOUN
ecj-13110	118	12	in	in	ADP
ecj-13110	118	13	pupillary	pupillary	ADJ
ecj-13110	118	14	diameter	diameter	NOUN
ecj-13110	118	15	and	and	CCONJ
ecj-13110	118	16	heat	heat	NOUN
ecj-13110	118	17	pain	pain	NOUN
ecj-13110	118	18	threshold	threshold	NOUN
ecj-13110	118	19	after	after	ADP
ecj-13110	118	20	naloxone	naloxone	ADJ
ecj-13110	118	21	administration	administration	NOUN
ecj-13110	118	22	.	.	PUNCT
ecj-13110	119	1	the	the	DET
ecj-13110	119	2	baseline	baseline	ADJ
ecj-13110	119	3	average	average	ADJ
ecj-13110	119	4	pupillary	pupillary	ADJ
ecj-13110	119	5	diameter	diameter	NOUN
ecj-13110	119	6	was	be	AUX
ecj-13110	119	7	similar	similar	ADJ
ecj-13110	119	8	between	between	ADP
ecj-13110	119	9	groups	group	NOUN
ecj-13110	119	10	(	(	PUNCT
ecj-13110	119	11	6.6	6.6	NUM
ecj-13110	119	12	mm	mm	NOUN
ecj-13110	119	13	in	in	ADP
ecj-13110	119	14	the	the	DET
ecj-13110	119	15	intranasal	intranasal	ADJ
ecj-13110	119	16	group	group	NOUN
ecj-13110	119	17	and	and	CCONJ
ecj-13110	119	18	6.8	6.8	NUM
ecj-13110	119	19	mm	mm	NOUN
ecj-13110	119	20	in	in	ADP
ecj-13110	119	21	the	the	DET
ecj-13110	119	22	intramuscular	intramuscular	ADJ
ecj-13110	119	23	group	group	NOUN
ecj-13110	119	24	)	)	PUNCT
ecj-13110	119	25	.	.	PUNCT
ecj-13110	120	1	after	after	ADP
ecj-13110	120	2	remifentanil	remifentanil	PROPN
ecj-13110	120	3	administration	administration	PROPN
ecj-13110	120	4	,	,	PUNCT
ecj-13110	120	5	both	both	DET
ecj-13110	120	6	groups	group	NOUN
ecj-13110	120	7	showed	show	VERB
ecj-13110	120	8	a	a	DET
ecj-13110	120	9	decrease	decrease	NOUN
ecj-13110	120	10	in	in	ADP
ecj-13110	120	11	pupillary	pupillary	ADJ
ecj-13110	120	12	diameter	diameter	NOUN
ecj-13110	120	13	(	(	PUNCT
ecj-13110	120	14	nadir	nadir	NOUN
ecj-13110	120	15	at	at	ADP
ecj-13110	120	16	2.9	2.9	NUM
ecj-13110	120	17	mm	mm	NOUN
ecj-13110	120	18	)	)	PUNCT
ecj-13110	120	19	.	.	PUNCT
ecj-13110	121	1	postnaloxone	postnaloxone	NOUN
ecj-13110	121	2	,	,	PUNCT
ecj-13110	121	3	miosis	miosis	ADJ
ecj-13110	121	4	reversal	reversal	NOUN
ecj-13110	121	5	was	be	AUX
ecj-13110	121	6	more	more	ADV
ecj-13110	121	7	pronounced	pronounce	VERB
ecj-13110	121	8	in	in	ADP
ecj-13110	121	9	the	the	DET
ecj-13110	121	10	intramuscular	intramuscular	ADJ
ecj-13110	121	11	group	group	NOUN
ecj-13110	121	12	.	.	PUNCT
ecj-13110	122	1	three	three	NUM
ecj-13110	122	2	remifentanil	remifentanil	NOUN
ecj-13110	122	3	doses	dose	NOUN
ecj-13110	122	4	(	(	PUNCT
ecj-13110	122	5	1	1	NUM
ecj-13110	122	6	ng	ng	PROPN
ecj-13110	122	7	/	/	SYM
ecj-13110	122	8	ml	ml	PROPN
ecj-13110	122	9	,	,	PUNCT
ecj-13110	122	10	1.3	1.3	NUM
ecj-13110	122	11	ng	ng	NOUN
ecj-13110	122	12	/	/	SYM
ecj-13110	122	13	ml	ml	PROPN
ecj-13110	122	14	,	,	PUNCT
ecj-13110	122	15	and	and	CCONJ
ecj-13110	122	16	2.5	2.5	NUM
ecj-13110	122	17	ng	ng	NOUN
ecj-13110	122	18	/	/	SYM
ecj-13110	122	19	ml	ml	PROPN
ecj-13110	122	20	)	)	PUNCT
ecj-13110	122	21	were	be	AUX
ecj-13110	122	22	tested	test	VERB
ecj-13110	122	23	with	with	ADP
ecj-13110	122	24	naloxone	naloxone	NOUN
ecj-13110	122	25	administered	administer	VERB
ecj-13110	122	26	at	at	ADP
ecj-13110	122	27	0.8	0.8	NUM
ecj-13110	122	28	mg	mg	NOUN
ecj-13110	122	29	for	for	ADP
ecj-13110	122	30	both	both	DET
ecj-13110	122	31	routes	route	NOUN
ecj-13110	122	32	.	.	PUNCT
ecj-13110	123	1	the	the	DET
ecj-13110	123	2	curves	curve	NOUN
ecj-13110	123	3	for	for	ADP
ecj-13110	123	4	intranasal	intranasal	ADJ
ecj-13110	123	5	and	and	CCONJ
ecj-13110	123	6	intramuscular	intramuscular	ADJ
ecj-13110	123	7	naloxone	naloxone	NOUN
ecj-13110	123	8	diverged	diverge	VERB
ecj-13110	123	9	immediately	immediately	ADV
ecj-13110	123	10	after	after	ADP
ecj-13110	123	11	dosing	dose	VERB
ecj-13110	123	12	but	but	CCONJ
ecj-13110	123	13	converged	converge	VERB
ecj-13110	123	14	at	at	ADP
ecj-13110	123	15	45	45	NUM
ecj-13110	123	16	minutes	minute	NOUN
ecj-13110	123	17	.	.	PUNCT
ecj-13110	124	1	miosis	miosis	NOUN
ecj-13110	124	2	reversal	reversal	NOUN
ecj-13110	124	3	peaked	peak	VERB
ecj-13110	124	4	at	at	ADP
ecj-13110	124	5	15	15	NUM
ecj-13110	124	6	minutes	minute	NOUN
ecj-13110	124	7	for	for	ADP
ecj-13110	124	8	intramuscular	intramuscular	ADJ
ecj-13110	124	9	naloxone	naloxone	NOUN
ecj-13110	124	10	and	and	CCONJ
ecj-13110	124	11	at	at	ADP
ecj-13110	124	12	30	30	NUM
ecj-13110	124	13	minutes	minute	NOUN
ecj-13110	124	14	for	for	ADP
ecj-13110	124	15	intranasal	intranasal	ADJ
ecj-13110	124	16	naloxone	naloxone	NOUN
ecj-13110	124	17	.	.	PUNCT
ecj-13110	125	1	heat	heat	NOUN
ecj-13110	125	2	pain	pain	NOUN
ecj-13110	125	3	thresholds	threshold	NOUN
ecj-13110	125	4	did	do	AUX
ecj-13110	125	5	not	not	PART
ecj-13110	125	6	differ	differ	VERB
ecj-13110	125	7	significantly	significantly	ADV
ecj-13110	125	8	between	between	ADP
ecj-13110	125	9	the	the	DET
ecj-13110	125	10	two	two	NUM
ecj-13110	125	11	administration	administration	NOUN
ecj-13110	125	12	routes	route	NOUN
ecj-13110	125	13	.	.	PUNCT
ecj-13110	126	1	the	the	DET
ecj-13110	126	2	pharmacokinetic	pharmacokinetic	ADJ
ecj-13110	126	3	analysis	analysis	NOUN
ecj-13110	126	4	revealed	reveal	VERB
ecj-13110	126	5	that	that	SCONJ
ecj-13110	126	6	the	the	DET
ecj-13110	126	7	average	average	NOUN
ecj-13110	126	8	dose	dose	NOUN
ecj-13110	126	9	for	for	ADP
ecj-13110	126	10	intranasal	intranasal	NOUN
ecj-13110	126	11	was	be	AUX
ecj-13110	126	12	0.75	0.75	NUM
ecj-13110	126	13	mg	mg	PROPN
ecj-13110	126	14	,	,	PUNCT
ecj-13110	126	15	and	and	CCONJ
ecj-13110	126	16	for	for	ADP
ecj-13110	126	17	intramuscular	intramuscular	ADJ
ecj-13110	126	18	was	be	AUX
ecj-13110	126	19	0.82	0.82	NUM
ecj-13110	126	20	mg	mg	NOUN
ecj-13110	126	21	.	.	PUNCT
ecj-13110	127	1	the	the	DET
ecj-13110	127	2	relative	relative	ADJ
ecj-13110	127	3	bioavailability	bioavailability	NOUN
ecj-13110	127	4	of	of	ADP
ecj-13110	127	5	intranasal	intranasal	NOUN
ecj-13110	127	6	versus	versus	ADP
ecj-13110	127	7	intramuscular	intramuscular	ADJ
ecj-13110	127	8	naloxone	naloxone	NOUN
ecj-13110	127	9	was	be	AUX
ecj-13110	127	10	0.75	0.75	NUM
ecj-13110	127	11	(	(	PUNCT
ecj-13110	127	12	95	95	NUM
ecj-13110	127	13	%	%	NOUN
ecj-13110	127	14	ci	ci	NOUN
ecj-13110	127	15	0.63	0.63	NUM
ecj-13110	127	16	-	-	PUNCT
ecj-13110	127	17	0.87	0.87	NUM
ecj-13110	127	18	)	)	PUNCT
ecj-13110	127	19	,	,	PUNCT
ecj-13110	127	20	with	with	ADP
ecj-13110	127	21	intranasal	intranasal	ADJ
ecj-13110	127	22	naloxone	naloxone	NOUN
ecj-13110	127	23	achieving	achieve	VERB
ecj-13110	127	24	a	a	DET
ecj-13110	127	25	tmax	tmax	ADJ
ecj-13110	127	26	three	three	NUM
ecj-13110	127	27	times	time	NOUN
ecj-13110	127	28	faster	fast	ADJ
ecj-13110	127	29	(	(	PUNCT
ecj-13110	127	30	7.75	7.75	NUM
ecj-13110	127	31	minutes	minute	NOUN
ecj-13110	127	32	)	)	PUNCT
ecj-13110	127	33	compared	compare	VERB
ecj-13110	127	34	to	to	ADP
ecj-13110	127	35	intramuscular	intramuscular	ADJ
ecj-13110	127	36	naloxone	naloxone	NOUN
ecj-13110	127	37	(	(	PUNCT
ecj-13110	127	38	28	28	NUM
ecj-13110	127	39	minutes	minute	NOUN
ecj-13110	127	40	)	)	PUNCT
ecj-13110	127	41	.	.	PUNCT
ecj-13110	128	1	however	however	ADV
ecj-13110	128	2	,	,	PUNCT
ecj-13110	128	3	cmax	cmax	NOUN
ecj-13110	128	4	and	and	CCONJ
ecj-13110	128	5	auclast	auclast	ADJ
ecj-13110	128	6	were	be	AUX
ecj-13110	128	7	approximately	approximately	ADV
ecj-13110	128	8	double	double	ADJ
ecj-13110	128	9	for	for	ADP
ecj-13110	128	10	intramuscular	intramuscular	ADJ
ecj-13110	128	11	naloxone	naloxone	NOUN
ecj-13110	128	12	.	.	PUNCT
ecj-13110	129	1	the	the	DET
ecj-13110	129	2	study	study	NOUN
ecj-13110	129	3	by	by	ADP
ecj-13110	129	4	dietze	dietze	PROPN
ecj-13110	129	5	et	et	PROPN
ecj-13110	129	6	al.14	al.14	PROPN
ecj-13110	129	7	aimed	aim	VERB
ecj-13110	129	8	to	to	PART
ecj-13110	129	9	compare	compare	VERB
ecj-13110	129	10	the	the	DET
ecj-13110	129	11	efficacy	efficacy	NOUN
ecj-13110	129	12	of	of	ADP
ecj-13110	129	13	0.8	0.8	NUM
ecj-13110	129	14	mg	mg	NOUN
ecj-13110	129	15	intramuscular	intramuscular	ADV
ecj-13110	129	16	versus	versus	X
ecj-13110	129	17	intranasal	intranasal	ADJ
ecj-13110	129	18	naloxone	naloxone	NOUN
ecj-13110	129	19	.	.	PUNCT
ecj-13110	130	1	the	the	DET
ecj-13110	130	2	results	result	NOUN
ecj-13110	130	3	showed	show	VERB
ecj-13110	130	4	that	that	SCONJ
ecj-13110	130	5	intramuscular	intramuscular	ADJ
ecj-13110	130	6	naloxone	naloxone	NOUN
ecj-13110	130	7	was	be	AUX
ecj-13110	130	8	associated	associate	VERB
ecj-13110	130	9	with	with	ADP
ecj-13110	130	10	a	a	DET
ecj-13110	130	11	lower	low	ADJ
ecj-13110	130	12	likelihood	likelihood	NOUN
ecj-13110	130	13	of	of	ADP
ecj-13110	130	14	requiring	require	VERB
ecj-13110	130	15	additional	additional	ADJ
ecj-13110	130	16	doses	dose	NOUN
ecj-13110	130	17	compared	compare	VERB
ecj-13110	130	18	to	to	ADP
ecj-13110	130	19	intranasal	intranasal	ADJ
ecj-13110	130	20	naloxone	naloxone	NOUN
ecj-13110	130	21	(	(	PUNCT
ecj-13110	130	22	8.6	8.6	NUM
ecj-13110	130	23	%	%	NOUN
ecj-13110	130	24	vs.	vs.	ADP
ecj-13110	130	25	23.1	23.1	NUM
ecj-13110	130	26	%	%	NOUN
ecj-13110	130	27	;	;	PUNCT
ecj-13110	130	28	or	or	CCONJ
ecj-13110	130	29	0.35	0.35	NUM
ecj-13110	130	30	;	;	PUNCT
ecj-13110	130	31	95	95	NUM
ecj-13110	130	32	%	%	NOUN
ecj-13110	130	33	ci	ci	NOUN
ecj-13110	130	34	0.15	0.15	NUM
ecj-13110	130	35	-	-	SYM
ecj-13110	130	36	0.66	0.66	NUM
ecj-13110	130	37	;	;	PUNCT
ecj-13110	130	38	p=0.002	p=0.002	X
ecj-13110	130	39	)	)	PUNCT
ecj-13110	130	40	.	.	PUNCT
ecj-13110	131	1	for	for	ADP
ecj-13110	131	2	the	the	DET
ecj-13110	131	3	endpoint	endpoint	NOUN
ecj-13110	131	4	of	of	ADP
ecj-13110	131	5	achieving	achieve	VERB
ecj-13110	131	6	a	a	DET
ecj-13110	131	7	respiratory	respiratory	ADJ
ecj-13110	131	8	rate	rate	NOUN
ecj-13110	131	9	of	of	ADP
ecj-13110	131	10	at	at	ADV
ecj-13110	131	11	least	least	ADV
ecj-13110	131	12	10	10	NUM
ecj-13110	131	13	breaths	breath	NOUN
ecj-13110	131	14	per	per	ADP
ecj-13110	131	15	minute	minute	NOUN
ecj-13110	131	16	,	,	PUNCT
ecj-13110	131	17	the	the	DET
ecj-13110	131	18	median	median	ADJ
ecj-13110	131	19	time	time	NOUN
ecj-13110	131	20	to	to	PART
ecj-13110	131	21	achieve	achieve	VERB
ecj-13110	131	22	a	a	DET
ecj-13110	131	23	respiratory	respiratory	ADJ
ecj-13110	131	24	rate	rate	NOUN
ecj-13110	131	25	of	of	ADP
ecj-13110	131	26	at	at	ADV
ecj-13110	131	27	least	least	ADV
ecj-13110	131	28	10	10	NUM
ecj-13110	131	29	breaths	breath	NOUN
ecj-13110	131	30	per	per	ADP
ecj-13110	131	31	minute	minute	NOUN
ecj-13110	131	32	was	be	AUX
ecj-13110	131	33	8.0	8.0	NUM
ecj-13110	131	34	minutes	minute	NOUN
ecj-13110	131	35	for	for	ADP
ecj-13110	131	36	intramuscular	intramuscular	ADJ
ecj-13110	131	37	and	and	CCONJ
ecj-13110	131	38	17.0	17.0	NUM
ecj-13110	131	39	minutes	minute	NOUN
ecj-13110	131	40	for	for	ADP
ecj-13110	131	41	intranasal	intranasal	ADJ
ecj-13110	131	42	naloxone	naloxone	NOUN
ecj-13110	131	43	,	,	PUNCT
ecj-13110	131	44	reflecting	reflect	VERB
ecj-13110	131	45	an	an	DET
ecj-13110	131	46	81	81	NUM
ecj-13110	131	47	%	%	NOUN
ecj-13110	131	48	increased	increase	VERB
ecj-13110	131	49	hazard	hazard	NOUN
ecj-13110	131	50	for	for	ADP
ecj-13110	131	51	intranasal	intranasal	ADJ
ecj-13110	131	52	administration	administration	NOUN
ecj-13110	131	53	(	(	PUNCT
ecj-13110	131	54	hr	hr	NOUN
ecj-13110	131	55	1.81	1.81	NUM
ecj-13110	131	56	;	;	PUNCT
ecj-13110	131	57	95	95	NUM
ecj-13110	131	58	%	%	NOUN
ecj-13110	131	59	ci	ci	NOUN
ecj-13110	131	60	1.28	1.28	NUM
ecj-13110	131	61	-	-	NUM
ecj-13110	131	62	2.56	2.56	NUM
ecj-13110	131	63	;	;	PUNCT
ecj-13110	131	64	p=0.001	p=0.001	NUM
ecj-13110	131	65	)	)	PUNCT
ecj-13110	131	66	.	.	PUNCT
ecj-13110	132	1	similarly	similarly	ADV
ecj-13110	132	2	,	,	PUNCT
ecj-13110	132	3	for	for	ADP
ecj-13110	132	4	the	the	DET
ecj-13110	132	5	endpoint	endpoint	NOUN
ecj-13110	132	6	of	of	ADP
ecj-13110	132	7	achieving	achieve	VERB
ecj-13110	132	8	a	a	DET
ecj-13110	132	9	glasgow	glasgow	ADJ
ecj-13110	132	10	coma	coma	NOUN
ecj-13110	132	11	scale	scale	NOUN
ecj-13110	132	12	score	score	NOUN
ecj-13110	132	13	of	of	ADP
ecj-13110	132	14	at	at	ADV
ecj-13110	132	15	least	least	ADV
ecj-13110	132	16	13	13	NUM
ecj-13110	132	17	,	,	PUNCT
ecj-13110	132	18	the	the	DET
ecj-13110	132	19	median	median	ADJ
ecj-13110	132	20	time	time	NOUN
ecj-13110	132	21	was	be	AUX
ecj-13110	132	22	shorter	short	ADJ
ecj-13110	132	23	for	for	ADP
ecj-13110	132	24	intramuscular	intramuscular	ADJ
ecj-13110	132	25	naloxone	naloxone	NOUN
ecj-13110	132	26	(	(	PUNCT
ecj-13110	132	27	8.0	8.0	NUM
ecj-13110	132	28	minutes	minute	NOUN
ecj-13110	132	29	)	)	PUNCT
ecj-13110	132	30	compared	compare	VERB
ecj-13110	132	31	to	to	ADP
ecj-13110	132	32	intranasal	intranasal	ADJ
ecj-13110	132	33	naloxone	naloxone	NOUN
ecj-13110	132	34	(	(	PUNCT
ecj-13110	132	35	15.0	15.0	NUM
ecj-13110	132	36	minutes	minute	NOUN
ecj-13110	132	37	)	)	PUNCT
ecj-13110	132	38	,	,	PUNCT
ecj-13110	132	39	indicating	indicate	VERB
ecj-13110	132	40	a	a	DET
ecj-13110	132	41	65	65	NUM
ecj-13110	132	42	%	%	NOUN
ecj-13110	132	43	increased	increase	VERB
ecj-13110	132	44	hazard	hazard	NOUN
ecj-13110	132	45	for	for	ADP
ecj-13110	132	46	intranasal	intranasal	ADJ
ecj-13110	132	47	naloxone	naloxone	NOUN
ecj-13110	132	48	(	(	PUNCT
ecj-13110	132	49	hr	hr	NOUN
ecj-13110	132	50	1.65	1.65	NUM
ecj-13110	132	51	;	;	PUNCT
ecj-13110	132	52	95	95	NUM
ecj-13110	132	53	%	%	NOUN
ecj-13110	132	54	ci	ci	NOUN
ecj-13110	132	55	1.21	1.21	NUM
ecj-13110	132	56	-	-	SYM
ecj-13110	132	57	2.25	2.25	NUM
ecj-13110	132	58	;	;	PUNCT
ecj-13110	132	59	p=0.002	p=0.002	X
ecj-13110	132	60	)	)	PUNCT
ecj-13110	132	61	.	.	PUNCT
ecj-13110	133	1	in	in	ADP
ecj-13110	133	2	skulberg	skulberg	PROPN
ecj-13110	133	3	et	et	PROPN
ecj-13110	133	4	al	al	PROPN
ecj-13110	133	5	.	.	PUNCT
ecj-13110	134	1	(	(	PUNCT
ecj-13110	134	2	2019),15	2019),15	NUM
ecj-13110	134	3	22	22	NUM
ecj-13110	134	4	healthy	healthy	ADJ
ecj-13110	134	5	volunteers	volunteer	NOUN
ecj-13110	134	6	received	receive	VERB
ecj-13110	134	7	naloxone	naloxone	NOUN
ecj-13110	134	8	via	via	ADP
ecj-13110	134	9	three	three	NUM
ecj-13110	134	10	routes	route	NOUN
ecj-13110	134	11	:	:	PUNCT
ecj-13110	134	12	intranasal	intranasal	NOUN
ecj-13110	134	13	(	(	PUNCT
ecj-13110	134	14	1.4	1.4	NUM
ecj-13110	134	15	mg	mg	NUM
ecj-13110	134	16	)	)	PUNCT
ecj-13110	134	17	,	,	PUNCT
ecj-13110	134	18	intramuscular	intramuscular	ADV
ecj-13110	134	19	(	(	PUNCT
ecj-13110	134	20	0.8	0.8	NUM
ecj-13110	134	21	mg	mg	NOUN
ecj-13110	134	22	)	)	PUNCT
ecj-13110	134	23	,	,	PUNCT
ecj-13110	134	24	and	and	CCONJ
ecj-13110	134	25	intravenous	intravenous	ADJ
ecj-13110	134	26	(	(	PUNCT
ecj-13110	134	27	0.4	0.4	NUM
ecj-13110	134	28	mg	mg	NUM
ecj-13110	134	29	)	)	PUNCT
ecj-13110	134	30	.	.	PUNCT
ecj-13110	135	1	the	the	DET
ecj-13110	135	2	study	study	NOUN
ecj-13110	135	3	aimed	aim	VERB
ecj-13110	135	4	to	to	PART
ecj-13110	135	5	compare	compare	VERB
ecj-13110	135	6	the	the	DET
ecj-13110	135	7	systemic	systemic	ADJ
ecj-13110	135	8	distribution	distribution	NOUN
ecj-13110	135	9	of	of	ADP
ecj-13110	135	10	1.4	1.4	NUM
ecj-13110	135	11	mg	mg	NOUN
ecj-13110	135	12	intranasal	intranasal	ADJ
ecj-13110	135	13	naloxone	naloxone	NOUN
ecj-13110	135	14	to	to	ADP
ecj-13110	135	15	0.8	0.8	NUM
ecj-13110	135	16	mg	mg	NOUN
ecj-13110	135	17	intramuscular	intramuscular	ADV
ecj-13110	135	18	and	and	CCONJ
ecj-13110	135	19	0.4	0.4	NUM
ecj-13110	135	20	mg	mg	PROPN
ecj-13110	135	21	intravenous	intravenous	ADJ
ecj-13110	135	22	doses	dose	NOUN
ecj-13110	135	23	.	.	PUNCT
ecj-13110	136	1	absorption	absorption	NOUN
ecj-13110	136	2	rates	rate	NOUN
ecj-13110	136	3	were	be	AUX
ecj-13110	136	4	higher	high	ADJ
ecj-13110	136	5	for	for	ADP
ecj-13110	136	6	intramuscular	intramuscular	ADJ
ecj-13110	136	7	naloxone	naloxone	NOUN
ecj-13110	136	8	,	,	PUNCT
ecj-13110	136	9	but	but	CCONJ
ecj-13110	136	10	intranasal	intranasal	ADJ
ecj-13110	136	11	naloxone	naloxone	NOUN
ecj-13110	136	12	achieved	achieve	VERB
ecj-13110	136	13	higher	high	ADJ
ecj-13110	136	14	plasma	plasma	NOUN
ecj-13110	136	15	concentrations	concentration	NOUN
ecj-13110	136	16	by	by	ADP
ecj-13110	136	17	15	15	NUM
ecj-13110	136	18	minutes	minute	NOUN
ecj-13110	136	19	post	post	ADJ
ecj-13110	136	20	-	-	ADJ
ecj-13110	136	21	dose	dose	ADJ
ecj-13110	136	22	.	.	PUNCT
ecj-13110	137	1	the	the	DET
ecj-13110	137	2	maximum	maximum	ADJ
ecj-13110	137	3	concentrations	concentration	NOUN
ecj-13110	137	4	(	(	PUNCT
ecj-13110	137	5	cmax	cmax	NOUN
ecj-13110	137	6	)	)	PUNCT
ecj-13110	137	7	of	of	ADP
ecj-13110	137	8	1.4	1.4	NUM
ecj-13110	137	9	mg	mg	NOUN
ecj-13110	137	10	intranasal	intranasal	ADJ
ecj-13110	137	11	naloxone	naloxone	NOUN
ecj-13110	137	12	and	and	CCONJ
ecj-13110	137	13	0.8	0.8	NUM
ecj-13110	137	14	mg	mg	NOUN
ecj-13110	137	15	intramuscular	intramuscular	ADJ
ecj-13110	137	16	naloxone	naloxone	NOUN
ecj-13110	137	17	were	be	AUX
ecj-13110	137	18	comparable	comparable	ADJ
ecj-13110	137	19	,	,	PUNCT
ecj-13110	137	20	with	with	ADP
ecj-13110	137	21	tmax	tmax	ADV
ecj-13110	137	22	being	be	AUX
ecj-13110	137	23	similar	similar	ADJ
ecj-13110	137	24	(	(	PUNCT
ecj-13110	137	25	p=0.098	p=0.098	NOUN
ecj-13110	137	26	)	)	PUNCT
ecj-13110	137	27	.	.	PUNCT
ecj-13110	138	1	the	the	DET
ecj-13110	138	2	time	time	NOUN
ecj-13110	138	3	to	to	ADP
ecj-13110	138	4	50	50	NUM
ecj-13110	138	5	%	%	NOUN
ecj-13110	138	6	of	of	ADP
ecj-13110	138	7	cmax	cmax	NOUN
ecj-13110	138	8	was	be	AUX
ecj-13110	138	9	10.1	10.1	NUM
ecj-13110	138	10	minutes	minute	NOUN
ecj-13110	138	11	for	for	ADP
ecj-13110	138	12	intranasal	intranasal	ADJ
ecj-13110	138	13	naloxone	naloxone	NOUN
ecj-13110	138	14	and	and	CCONJ
ecj-13110	138	15	6.5	6.5	NUM
ecj-13110	138	16	minutes	minute	NOUN
ecj-13110	138	17	for	for	ADP
ecj-13110	138	18	intramuscular	intramuscular	ADJ
ecj-13110	138	19	naloxone	naloxone	NOUN
ecj-13110	138	20	(	(	PUNCT
ecj-13110	138	21	p=0.061	p=0.061	NOUN
ecj-13110	138	22	)	)	PUNCT
ecj-13110	138	23	.	.	PUNCT
ecj-13110	139	1	in	in	ADP
ecj-13110	139	2	skulberg	skulberg	PROPN
ecj-13110	139	3	et	et	PROPN
ecj-13110	139	4	al	al	PROPN
ecj-13110	139	5	.	.	PUNCT
ecj-13110	140	1	(	(	PUNCT
ecj-13110	140	2	2022),13	2022),13	NUM
ecj-13110	140	3	201	201	NUM
ecj-13110	140	4	opioid	opioid	ADJ
ecj-13110	140	5	overdose	overdose	ADJ
ecj-13110	140	6	patients	patient	NOUN
ecj-13110	140	7	were	be	AUX
ecj-13110	140	8	randomized	randomize	VERB
ecj-13110	140	9	to	to	PART
ecj-13110	140	10	receive	receive	VERB
ecj-13110	140	11	either	either	CCONJ
ecj-13110	140	12	intramuscular	intramuscular	ADJ
ecj-13110	140	13	(	(	PUNCT
ecj-13110	140	14	147	147	NUM
ecj-13110	140	15	participants	participant	NOUN
ecj-13110	140	16	)	)	PUNCT
ecj-13110	140	17	review	review	NOUN
ecj-13110	140	18	table	table	NOUN
ecj-13110	140	19	2	2	NUM
ecj-13110	140	20	.	.	PUNCT
ecj-13110	140	21	quality	quality	NOUN
ecj-13110	140	22	appraisal	appraisal	NOUN
ecj-13110	140	23	according	accord	VERB
ecj-13110	140	24	to	to	ADP
ecj-13110	140	25	the	the	DET
ecj-13110	140	26	dixon	dixon	NOUN
ecj-13110	140	27	-	-	PUNCT
ecj-13110	140	28	woods	wood	NOUN
ecj-13110	140	29	scale	scale	NOUN
ecj-13110	140	30	.	.	PUNCT
ecj-13110	141	1	author(s	author(s	NOUN
ecj-13110	141	2	)	)	PUNCT
ecj-13110	141	3	(	(	PUNCT
ecj-13110	141	4	year	year	NOUN
ecj-13110	141	5	)	)	PUNCT
ecj-13110	141	6	are	be	AUX
ecj-13110	141	7	the	the	DET
ecj-13110	141	8	aims	aim	NOUN
ecj-13110	141	9	and	and	CCONJ
ecj-13110	141	10	is	be	AUX
ecj-13110	141	11	the	the	DET
ecj-13110	141	12	research	research	NOUN
ecj-13110	141	13	design	design	NOUN
ecj-13110	141	14	clearly	clearly	ADV
ecj-13110	141	15	do	do	VERB
ecj-13110	141	16	the	the	DET
ecj-13110	141	17	researchers	researcher	NOUN
ecj-13110	141	18	provide	provide	VERB
ecj-13110	141	19	do	do	AUX
ecj-13110	141	20	the	the	DET
ecj-13110	141	21	researchers	researcher	NOUN
ecj-13110	141	22	display	display	VERB
ecj-13110	141	23	is	be	AUX
ecj-13110	141	24	the	the	DET
ecj-13110	141	25	method	method	NOUN
ecj-13110	141	26	of	of	ADP
ecj-13110	141	27	score	score	NOUN
ecj-13110	141	28	objectives	objective	NOUN
ecj-13110	141	29	of	of	ADP
ecj-13110	141	30	the	the	DET
ecj-13110	141	31	specified	specified	ADJ
ecj-13110	141	32	and	and	CCONJ
ecj-13110	141	33	appropriate	appropriate	ADJ
ecj-13110	141	34	a	a	DET
ecj-13110	141	35	clear	clear	ADJ
ecj-13110	141	36	account	account	NOUN
ecj-13110	141	37	of	of	ADP
ecj-13110	141	38	enough	enough	ADJ
ecj-13110	141	39	data	datum	NOUN
ecj-13110	141	40	to	to	PART
ecj-13110	141	41	support	support	VERB
ecj-13110	141	42	analysis	analysis	NOUN
ecj-13110	141	43	appropriate	appropriate	ADJ
ecj-13110	141	44	research	research	NOUN
ecj-13110	141	45	for	for	ADP
ecj-13110	141	46	the	the	DET
ecj-13110	141	47	aims	aim	NOUN
ecj-13110	141	48	and	and	CCONJ
ecj-13110	141	49	objectives	objective	VERB
ecj-13110	141	50	the	the	DET
ecj-13110	141	51	process	process	NOUN
ecj-13110	141	52	by	by	ADP
ecj-13110	141	53	the	the	DET
ecj-13110	141	54	which	which	PRON
ecj-13110	141	55	their	their	PRON
ecj-13110	141	56	interpretations	interpretation	NOUN
ecj-13110	141	57	and	and	CCONJ
ecj-13110	141	58	adequately	adequately	ADV
ecj-13110	141	59	clearly	clearly	ADV
ecj-13110	141	60	stated	state	VERB
ecj-13110	141	61	?	?	PUNCT
ecj-13110	142	1	of	of	ADP
ecj-13110	142	2	the	the	DET
ecj-13110	142	3	research	research	NOUN
ecj-13110	142	4	?	?	PUNCT
ecj-13110	143	1	their	their	PRON
ecj-13110	143	2	findings	finding	NOUN
ecj-13110	143	3	were	be	AUX
ecj-13110	143	4	reproduced	reproduce	VERB
ecj-13110	143	5	?	?	PUNCT
ecj-13110	144	1	and	and	CCONJ
ecj-13110	144	2	conclusions	conclusion	NOUN
ecj-13110	144	3	?	?	PUNCT
ecj-13110	144	4	explicated	explicate	VERB
ecj-13110	144	5	?	?	PUNCT
ecj-13110	145	1	mcdonald	mcdonald	PROPN
ecj-13110	145	2	et	et	PROPN
ecj-13110	145	3	al	al	PROPN
ecj-13110	145	4	.	.	PROPN
ecj-13110	146	1	(	(	PUNCT
ecj-13110	146	2	2018	2018	NUM
ecj-13110	146	3	)	)	PUNCT
ecj-13110	147	1	yes	yes	INTJ
ecj-13110	148	1	yes	yes	INTJ
ecj-13110	149	1	yes	yes	INTJ
ecj-13110	150	1	yes	yes	INTJ
ecj-13110	151	1	yes	yes	INTJ
ecj-13110	151	2	excellent	excellent	ADJ
ecj-13110	151	3	skulberg	skulberg	PROPN
ecj-13110	151	4	et	et	PROPN
ecj-13110	151	5	al	al	PROPN
ecj-13110	151	6	.	.	PROPN
ecj-13110	152	1	(	(	PUNCT
ecj-13110	152	2	2018	2018	NUM
ecj-13110	152	3	)	)	PUNCT
ecj-13110	153	1	yes	yes	INTJ
ecj-13110	154	1	yes	yes	INTJ
ecj-13110	155	1	yes	yes	INTJ
ecj-13110	156	1	yes	yes	INTJ
ecj-13110	157	1	yes	yes	INTJ
ecj-13110	157	2	excellent	excellent	INTJ
ecj-13110	157	3	dietze	dietze	NOUN
ecj-13110	157	4	et	et	PROPN
ecj-13110	157	5	al	al	PROPN
ecj-13110	157	6	.	.	PROPN
ecj-13110	158	1	(	(	PUNCT
ecj-13110	158	2	2019	2019	NUM
ecj-13110	158	3	)	)	PUNCT
ecj-13110	159	1	yes	yes	INTJ
ecj-13110	160	1	yes	yes	INTJ
ecj-13110	161	1	yes	yes	INTJ
ecj-13110	162	1	yes	yes	INTJ
ecj-13110	163	1	yes	yes	INTJ
ecj-13110	163	2	excellent	excellent	ADJ
ecj-13110	163	3	skulberg	skulberg	PROPN
ecj-13110	163	4	et	et	PROPN
ecj-13110	163	5	al	al	PROPN
ecj-13110	163	6	.	.	PROPN
ecj-13110	164	1	(	(	PUNCT
ecj-13110	164	2	2019	2019	NUM
ecj-13110	164	3	)	)	PUNCT
ecj-13110	165	1	yes	yes	INTJ
ecj-13110	166	1	yes	yes	INTJ
ecj-13110	167	1	yes	yes	INTJ
ecj-13110	168	1	yes	yes	INTJ
ecj-13110	169	1	yes	yes	INTJ
ecj-13110	169	2	excellent	excellent	ADJ
ecj-13110	169	3	skulberg	skulberg	PROPN
ecj-13110	169	4	et	et	PROPN
ecj-13110	169	5	al	al	PROPN
ecj-13110	169	6	.	.	PROPN
ecj-13110	170	1	(	(	PUNCT
ecj-13110	170	2	2022	2022	NUM
ecj-13110	170	3	)	)	PUNCT
ecj-13110	171	1	yes	yes	INTJ
ecj-13110	172	1	yes	yes	INTJ
ecj-13110	173	1	yes	yes	INTJ
ecj-13110	174	1	yes	yes	INTJ
ecj-13110	175	1	yes	yes	INTJ
ecj-13110	175	2	excellent	excellent	ADJ
ecj-13110	176	1	[	[	X
ecj-13110	176	2	page	page	NOUN
ecj-13110	176	3	44	44	NUM
ecj-13110	176	4	]	]	PUNCT
ecj-13110	177	1	[	[	X
ecj-13110	177	2	emergency	emergency	NOUN
ecj-13110	177	3	care	care	NOUN
ecj-13110	177	4	journal	journal	NOUN
ecj-13110	177	5	2025	2025	NUM
ecj-13110	177	6	;	;	PUNCT
ecj-13110	177	7	21:13110	21:13110	NUM
ecj-13110	177	8	]	]	PUNCT
ecj-13110	177	9	or	or	CCONJ
ecj-13110	177	10	intranasal	intranasal	NOUN
ecj-13110	177	11	(	(	PUNCT
ecj-13110	177	12	139	139	NUM
ecj-13110	177	13	participants	participant	NOUN
ecj-13110	177	14	)	)	PUNCT
ecj-13110	177	15	naloxone	naloxone	NOUN
ecj-13110	177	16	.	.	PUNCT
ecj-13110	178	1	the	the	DET
ecj-13110	178	2	intramuscular	intramuscular	ADJ
ecj-13110	178	3	group	group	NOUN
ecj-13110	178	4	had	have	VERB
ecj-13110	178	5	a	a	DET
ecj-13110	178	6	higher	high	ADJ
ecj-13110	178	7	rate	rate	NOUN
ecj-13110	178	8	of	of	ADP
ecj-13110	178	9	achieving	achieve	VERB
ecj-13110	178	10	spontaneous	spontaneous	ADJ
ecj-13110	178	11	respiration	respiration	NOUN
ecj-13110	178	12	within	within	ADP
ecj-13110	178	13	10	10	NUM
ecj-13110	178	14	minutes	minute	NOUN
ecj-13110	178	15	(	(	PUNCT
ecj-13110	178	16	97.2	97.2	NUM
ecj-13110	178	17	%	%	NOUN
ecj-13110	178	18	)	)	PUNCT
ecj-13110	178	19	compared	compare	VERB
ecj-13110	178	20	to	to	ADP
ecj-13110	178	21	the	the	DET
ecj-13110	178	22	intranasal	intranasal	ADJ
ecj-13110	178	23	group	group	NOUN
ecj-13110	178	24	(	(	PUNCT
ecj-13110	178	25	79.6	79.6	NUM
ecj-13110	178	26	%	%	NOUN
ecj-13110	178	27	)	)	PUNCT
ecj-13110	178	28	.	.	PUNCT
ecj-13110	179	1	intramuscular	intramuscular	ADJ
ecj-13110	179	2	naloxone	naloxone	NOUN
ecj-13110	179	3	led	lead	VERB
ecj-13110	179	4	to	to	ADP
ecj-13110	179	5	a	a	DET
ecj-13110	179	6	faster	fast	ADJ
ecj-13110	179	7	return	return	NOUN
ecj-13110	179	8	to	to	ADP
ecj-13110	179	9	spontaneous	spontaneous	ADJ
ecj-13110	179	10	respiration	respiration	NOUN
ecj-13110	179	11	,	,	PUNCT
ecj-13110	179	12	with	with	ADP
ecj-13110	179	13	an	an	DET
ecj-13110	179	14	average	average	NOUN
ecj-13110	179	15	of	of	ADP
ecj-13110	179	16	2.3	2.3	NUM
ecj-13110	179	17	minutes	minute	NOUN
ecj-13110	179	18	(	(	PUNCT
ecj-13110	179	19	95	95	NUM
ecj-13110	179	20	%	%	NOUN
ecj-13110	179	21	ci	ci	NOUN
ecj-13110	179	22	1.6	1.6	NUM
ecj-13110	179	23	-	-	SYM
ecj-13110	179	24	3.0	3.0	NUM
ecj-13110	179	25	)	)	PUNCT
ecj-13110	179	26	compared	compare	VERB
ecj-13110	179	27	to	to	ADP
ecj-13110	179	28	6.4	6.4	NUM
ecj-13110	179	29	minutes	minute	NOUN
ecj-13110	179	30	for	for	ADP
ecj-13110	179	31	intranasal	intranasal	ADJ
ecj-13110	179	32	naloxone	naloxone	NOUN
ecj-13110	179	33	.	.	PUNCT
ecj-13110	180	1	additional	additional	ADJ
ecj-13110	180	2	naloxone	naloxone	NOUN
ecj-13110	180	3	was	be	AUX
ecj-13110	180	4	administered	administer	VERB
ecj-13110	180	5	to	to	ADP
ecj-13110	180	6	9.3	9.3	NUM
ecj-13110	180	7	%	%	NOUN
ecj-13110	180	8	of	of	ADP
ecj-13110	180	9	the	the	DET
ecj-13110	180	10	patients	patient	NOUN
ecj-13110	180	11	in	in	ADP
ecj-13110	180	12	the	the	DET
ecj-13110	180	13	intramuscular	intramuscular	ADJ
ecj-13110	180	14	group	group	NOUN
ecj-13110	180	15	and	and	CCONJ
ecj-13110	180	16	29.0	29.0	NUM
ecj-13110	180	17	%	%	NOUN
ecj-13110	180	18	of	of	ADP
ecj-13110	180	19	the	the	DET
ecj-13110	180	20	intranasal	intranasal	NOUN
ecj-13110	180	21	group	group	NOUN
ecj-13110	180	22	.	.	PUNCT
ecj-13110	181	1	withdrawal	withdrawal	NOUN
ecj-13110	181	2	symptoms	symptom	NOUN
ecj-13110	181	3	occurred	occur	VERB
ecj-13110	181	4	in	in	ADP
ecj-13110	181	5	7.5	7.5	NUM
ecj-13110	181	6	%	%	NOUN
ecj-13110	181	7	of	of	ADP
ecj-13110	181	8	the	the	DET
ecj-13110	181	9	patients	patient	NOUN
ecj-13110	181	10	in	in	ADP
ecj-13110	181	11	the	the	DET
ecj-13110	181	12	intramuscular	intramuscular	ADJ
ecj-13110	181	13	group	group	NOUN
ecj-13110	181	14	and	and	CCONJ
ecj-13110	181	15	5.4	5.4	NUM
ecj-13110	181	16	%	%	NOUN
ecj-13110	181	17	of	of	ADP
ecj-13110	181	18	the	the	DET
ecj-13110	181	19	intranasal	intranasal	NOUN
ecj-13110	181	20	group	group	NOUN
ecj-13110	181	21	.	.	PUNCT
ecj-13110	182	1	discussion	discussion	NOUN
ecj-13110	182	2	as	as	SCONJ
ecj-13110	182	3	indicated	indicate	VERB
ecj-13110	182	4	in	in	ADP
ecj-13110	182	5	the	the	DET
ecj-13110	182	6	results	result	NOUN
ecj-13110	182	7	section	section	NOUN
ecj-13110	182	8	,	,	PUNCT
ecj-13110	182	9	the	the	DET
ecj-13110	182	10	majority	majority	NOUN
ecj-13110	182	11	of	of	ADP
ecj-13110	182	12	the	the	DET
ecj-13110	182	13	selected	select	VERB
ecj-13110	182	14	studies	study	NOUN
ecj-13110	182	15	emphasize	emphasize	VERB
ecj-13110	182	16	the	the	DET
ecj-13110	182	17	benefits	benefit	NOUN
ecj-13110	182	18	of	of	ADP
ecj-13110	182	19	using	use	VERB
ecj-13110	182	20	intranasal	intranasal	ADJ
ecj-13110	182	21	naloxone	naloxone	NOUN
ecj-13110	182	22	for	for	ADP
ecj-13110	182	23	overdose	overdose	ADJ
ecj-13110	182	24	cases	case	NOUN
ecj-13110	182	25	in	in	ADP
ecj-13110	182	26	out	out	ADV
ecj-13110	182	27	-	-	PUNCT
ecj-13110	182	28	of	of	ADP
ecj-13110	182	29	-	-	PUNCT
ecj-13110	182	30	hospital	hospital	NOUN
ecj-13110	182	31	settings	setting	NOUN
ecj-13110	182	32	,	,	PUNCT
ecj-13110	182	33	an	an	DET
ecj-13110	182	34	issue	issue	NOUN
ecj-13110	182	35	of	of	ADP
ecj-13110	182	36	growing	grow	VERB
ecj-13110	182	37	urgency	urgency	NOUN
ecj-13110	182	38	due	due	ADP
ecj-13110	182	39	to	to	ADP
ecj-13110	182	40	the	the	DET
ecj-13110	182	41	rise	rise	NOUN
ecj-13110	182	42	in	in	ADP
ecj-13110	182	43	opioid	opioid	ADJ
ecj-13110	182	44	overdoses	overdose	NOUN
ecj-13110	182	45	,	,	PUNCT
ecj-13110	182	46	particularly	particularly	ADV
ecj-13110	182	47	those	those	PRON
ecj-13110	182	48	caused	cause	VERB
ecj-13110	182	49	by	by	ADP
ecj-13110	182	50	synthetic	synthetic	ADJ
ecj-13110	182	51	opioids	opioid	NOUN
ecj-13110	182	52	.	.	PUNCT
ecj-13110	183	1	the	the	DET
ecj-13110	183	2	inclusion	inclusion	NOUN
ecj-13110	183	3	of	of	ADP
ecj-13110	183	4	studies	study	NOUN
ecj-13110	183	5	from	from	ADP
ecj-13110	183	6	alternative	alternative	ADJ
ecj-13110	183	7	settings	setting	NOUN
ecj-13110	183	8	highlights	highlight	VERB
ecj-13110	183	9	the	the	DET
ecj-13110	183	10	limited	limited	ADJ
ecj-13110	183	11	availability	availability	NOUN
ecj-13110	183	12	of	of	ADP
ecj-13110	183	13	evidence	evidence	NOUN
ecj-13110	183	14	specific	specific	ADJ
ecj-13110	183	15	to	to	ADP
ecj-13110	183	16	prehospital	prehospital	NOUN
ecj-13110	183	17	care	care	NOUN
ecj-13110	183	18	.	.	PUNCT
ecj-13110	184	1	this	this	DET
ecj-13110	184	2	approach	approach	NOUN
ecj-13110	184	3	provided	provide	VERB
ecj-13110	184	4	a	a	DET
ecj-13110	184	5	more	more	ADV
ecj-13110	184	6	comprehensive	comprehensive	ADJ
ecj-13110	184	7	understanding	understanding	NOUN
ecj-13110	184	8	of	of	ADP
ecj-13110	184	9	naloxone	naloxone	NOUN
ecj-13110	184	10	’s	’s	PART
ecj-13110	184	11	effectiveness	effectiveness	NOUN
ecj-13110	184	12	while	while	SCONJ
ecj-13110	184	13	stressing	stress	VERB
ecj-13110	184	14	the	the	DET
ecj-13110	184	15	need	need	NOUN
ecj-13110	184	16	for	for	ADP
ecj-13110	184	17	further	further	ADJ
ecj-13110	184	18	research	research	NOUN
ecj-13110	184	19	in	in	ADP
ecj-13110	184	20	prehospital	prehospital	ADJ
ecj-13110	184	21	contexts	context	NOUN
ecj-13110	184	22	.	.	PUNCT
ecj-13110	185	1	these	these	DET
ecj-13110	185	2	findings	finding	NOUN
ecj-13110	185	3	align	align	VERB
ecj-13110	185	4	with	with	ADP
ecj-13110	185	5	those	those	PRON
ecj-13110	185	6	from	from	ADP
ecj-13110	185	7	previous	previous	ADJ
ecj-13110	185	8	reviews	review	NOUN
ecj-13110	185	9	,	,	PUNCT
ecj-13110	185	10	particularly	particularly	ADV
ecj-13110	185	11	yousefifard	yousefifard	VERB
ecj-13110	185	12	et	et	PROPN
ecj-13110	185	13	al	al	PROPN
ecj-13110	185	14	.	.	PROPN
ecj-13110	185	15	,18	,18	PUNCT
ecj-13110	186	1	but	but	CCONJ
ecj-13110	186	2	several	several	ADJ
ecj-13110	186	3	factors	factor	NOUN
ecj-13110	186	4	need	need	VERB
ecj-13110	186	5	to	to	PART
ecj-13110	186	6	be	be	AUX
ecj-13110	186	7	considered	consider	VERB
ecj-13110	186	8	,	,	PUNCT
ecj-13110	186	9	as	as	SCONJ
ecj-13110	186	10	they	they	PRON
ecj-13110	186	11	may	may	AUX
ecj-13110	186	12	obscure	obscure	VERB
ecj-13110	186	13	the	the	DET
ecj-13110	186	14	efficacy	efficacy	NOUN
ecj-13110	186	15	of	of	ADP
ecj-13110	186	16	in	in	ADP
ecj-13110	186	17	naloxone	naloxone	NOUN
ecj-13110	186	18	compared	compare	VERB
ecj-13110	186	19	to	to	ADP
ecj-13110	186	20	the	the	DET
ecj-13110	186	21	intramuscular	intramuscular	ADJ
ecj-13110	186	22	formulation	formulation	NOUN
ecj-13110	186	23	,	,	PUNCT
ecj-13110	186	24	particularly	particularly	ADV
ecj-13110	186	25	regarding	regard	VERB
ecj-13110	186	26	the	the	DET
ecj-13110	186	27	balance	balance	NOUN
ecj-13110	186	28	between	between	ADP
ecj-13110	186	29	the	the	DET
ecj-13110	186	30	dosages	dosage	NOUN
ecj-13110	186	31	of	of	ADP
ecj-13110	186	32	the	the	DET
ecj-13110	186	33	two	two	NUM
ecj-13110	186	34	different	different	ADJ
ecj-13110	186	35	formulations	formulation	NOUN
ecj-13110	186	36	.	.	PUNCT
ecj-13110	187	1	in	in	ADP
ecj-13110	187	2	particular	particular	ADJ
ecj-13110	187	3	,	,	PUNCT
ecj-13110	187	4	it	it	PRON
ecj-13110	187	5	is	be	AUX
ecj-13110	187	6	noteworthy	noteworthy	ADJ
ecj-13110	187	7	that	that	SCONJ
ecj-13110	187	8	mcdonald	mcdonald	PROPN
ecj-13110	187	9	et	et	PROPN
ecj-13110	187	10	al.17	al.17	PROPN
ecj-13110	187	11	demonstrated	demonstrate	VERB
ecj-13110	187	12	that	that	SCONJ
ecj-13110	187	13	a	a	DET
ecj-13110	187	14	2	2	NUM
ecj-13110	187	15	mg	mg	NOUN
ecj-13110	187	16	in	in	ADP
ecj-13110	187	17	dose	dose	PROPN
ecj-13110	187	18	of	of	ADP
ecj-13110	187	19	naloxone	naloxone	NOUN
ecj-13110	187	20	can	can	AUX
ecj-13110	187	21	achieve	achieve	VERB
ecj-13110	187	22	plasma	plasma	NOUN
ecj-13110	187	23	levels	level	NOUN
ecj-13110	187	24	comparable	comparable	ADJ
ecj-13110	187	25	to	to	ADP
ecj-13110	187	26	those	those	PRON
ecj-13110	187	27	obtained	obtain	VERB
ecj-13110	187	28	with	with	ADP
ecj-13110	187	29	five	five	NUM
ecj-13110	187	30	0.4	0.4	NUM
ecj-13110	187	31	mg	mg	PROPN
ecj-13110	188	1	i	i	PROPN
ecj-13110	188	2	m	m	VERB
ecj-13110	188	3	doses	dose	NOUN
ecj-13110	188	4	,	,	PUNCT
ecj-13110	188	5	totaling	total	VERB
ecj-13110	188	6	2	2	NUM
ecj-13110	188	7	mg	mg	NOUN
ecj-13110	188	8	.	.	PUNCT
ecj-13110	189	1	despite	despite	SCONJ
ecj-13110	189	2	the	the	DET
ecj-13110	189	3	lower	low	ADJ
ecj-13110	189	4	bioavailability	bioavailability	NOUN
ecj-13110	189	5	of	of	ADP
ecj-13110	189	6	in	in	ADP
ecj-13110	189	7	naloxone	naloxone	NOUN
ecj-13110	189	8	,	,	PUNCT
ecj-13110	189	9	this	this	PRON
ecj-13110	189	10	was	be	AUX
ecj-13110	189	11	in	in	ADP
ecj-13110	189	12	line	line	NOUN
ecj-13110	189	13	with	with	ADP
ecj-13110	189	14	our	our	PRON
ecj-13110	189	15	results	result	NOUN
ecj-13110	189	16	,	,	PUNCT
ecj-13110	189	17	where	where	SCONJ
ecj-13110	189	18	in	in	ADP
ecj-13110	189	19	naloxone	naloxone	NOUN
ecj-13110	189	20	demonstrated	demonstrate	VERB
ecj-13110	189	21	comparable	comparable	ADJ
ecj-13110	189	22	,	,	PUNCT
ecj-13110	189	23	if	if	SCONJ
ecj-13110	189	24	not	not	PART
ecj-13110	189	25	higher	high	ADJ
ecj-13110	189	26	,	,	PUNCT
ecj-13110	189	27	plasma	plasma	NOUN
ecj-13110	189	28	levels	level	NOUN
ecj-13110	189	29	over	over	ADP
ecj-13110	189	30	a	a	DET
ecj-13110	189	31	longer	long	ADJ
ecj-13110	189	32	duration	duration	NOUN
ecj-13110	189	33	.	.	PUNCT
ecj-13110	190	1	however	however	ADV
ecj-13110	190	2	,	,	PUNCT
ecj-13110	190	3	high	high	ADJ
ecj-13110	190	4	doses	dose	NOUN
ecj-13110	190	5	of	of	ADP
ecj-13110	190	6	naloxone	naloxone	NOUN
ecj-13110	190	7	may	may	AUX
ecj-13110	190	8	induce	induce	VERB
ecj-13110	190	9	severe	severe	ADJ
ecj-13110	190	10	withdrawal	withdrawal	NOUN
ecj-13110	190	11	symptoms,19	symptoms,19	NOUN
ecj-13110	190	12	-	-	PUNCT
ecj-13110	190	13	21	21	NUM
ecj-13110	190	14	and	and	CCONJ
ecj-13110	190	15	therefore	therefore	ADV
ecj-13110	190	16	,	,	PUNCT
ecj-13110	190	17	it	it	PRON
ecj-13110	190	18	is	be	AUX
ecj-13110	190	19	advisable	advisable	ADJ
ecj-13110	190	20	to	to	PART
ecj-13110	190	21	gradually	gradually	ADV
ecj-13110	190	22	escalate	escalate	VERB
ecj-13110	190	23	the	the	DET
ecj-13110	190	24	dose	dose	NOUN
ecj-13110	190	25	to	to	ADP
ecj-13110	190	26	2	2	NUM
ecj-13110	190	27	mg	mg	NOUN
ecj-13110	190	28	,	,	PUNCT
ecj-13110	190	29	as	as	SCONJ
ecj-13110	190	30	recommended	recommend	VERB
ecj-13110	190	31	by	by	ADP
ecj-13110	190	32	who	who	PRON
ecj-13110	190	33	guidelines.9	guidelines.9	ADJ
ecj-13110	190	34	repeated	repeat	VERB
ecj-13110	190	35	simulations	simulation	NOUN
ecj-13110	190	36	of	of	ADP
ecj-13110	190	37	2	2	NUM
ecj-13110	190	38	mg	mg	NOUN
ecj-13110	190	39	in	in	ADP
ecj-13110	190	40	doses	dose	NOUN
ecj-13110	190	41	produced	produce	VERB
ecj-13110	190	42	plasma	plasma	NOUN
ecj-13110	190	43	levels	level	NOUN
ecj-13110	190	44	comparable	comparable	ADJ
ecj-13110	190	45	to	to	ADP
ecj-13110	190	46	a	a	DET
ecj-13110	190	47	single	single	ADJ
ecj-13110	190	48	4	4	NUM
ecj-13110	190	49	mg	mg	NOUN
ecj-13110	190	50	in	in	ADP
ecj-13110	190	51	dose	dose	PROPN
ecj-13110	190	52	,	,	PUNCT
ecj-13110	190	53	suggesting	suggest	VERB
ecj-13110	190	54	that	that	SCONJ
ecj-13110	190	55	an	an	DET
ecj-13110	190	56	initial	initial	ADJ
ecj-13110	190	57	2	2	NUM
ecj-13110	190	58	mg	mg	NOUN
ecj-13110	190	59	dose	dose	NOUN
ecj-13110	190	60	followed	follow	VERB
ecj-13110	190	61	by	by	ADP
ecj-13110	190	62	a	a	DET
ecj-13110	190	63	second	second	ADJ
ecj-13110	190	64	dose	dose	NOUN
ecj-13110	190	65	,	,	PUNCT
ecj-13110	190	66	if	if	SCONJ
ecj-13110	190	67	necessary	necessary	ADJ
ecj-13110	190	68	,	,	PUNCT
ecj-13110	190	69	could	could	AUX
ecj-13110	190	70	mitigate	mitigate	VERB
ecj-13110	190	71	the	the	DET
ecj-13110	190	72	risk	risk	NOUN
ecj-13110	190	73	of	of	ADP
ecj-13110	190	74	adverse	adverse	ADJ
ecj-13110	190	75	effects	effect	NOUN
ecj-13110	190	76	and	and	CCONJ
ecj-13110	190	77	enhance	enhance	VERB
ecj-13110	190	78	safety	safety	NOUN
ecj-13110	190	79	for	for	ADP
ecj-13110	190	80	overdose	overdose	ADJ
ecj-13110	190	81	victims	victim	NOUN
ecj-13110	190	82	and	and	CCONJ
ecj-13110	190	83	responders.17	responders.17	NOUN
ecj-13110	190	84	these	these	DET
ecj-13110	190	85	findings	finding	NOUN
ecj-13110	190	86	highlight	highlight	VERB
ecj-13110	190	87	the	the	DET
ecj-13110	190	88	concern	concern	NOUN
ecj-13110	190	89	about	about	ADP
ecj-13110	190	90	withdrawal	withdrawal	NOUN
ecj-13110	190	91	symptoms	symptom	NOUN
ecj-13110	190	92	,	,	PUNCT
ecj-13110	190	93	which	which	PRON
ecj-13110	190	94	may	may	AUX
ecj-13110	190	95	negatively	negatively	ADV
ecj-13110	190	96	influence	influence	VERB
ecj-13110	190	97	naloxone	naloxone	NOUN
ecj-13110	190	98	’s	’s	PART
ecj-13110	190	99	perception	perception	NOUN
ecj-13110	190	100	among	among	ADP
ecj-13110	190	101	opioid	opioid	ADJ
ecj-13110	190	102	users	user	NOUN
ecj-13110	190	103	,	,	PUNCT
ecj-13110	190	104	underscoring	underscore	VERB
ecj-13110	190	105	the	the	DET
ecj-13110	190	106	need	need	NOUN
ecj-13110	190	107	for	for	ADP
ecj-13110	190	108	a	a	DET
ecj-13110	190	109	cautious	cautious	ADJ
ecj-13110	190	110	approach	approach	NOUN
ecj-13110	190	111	in	in	ADP
ecj-13110	190	112	its	its	PRON
ecj-13110	190	113	administration.22	administration.22	NOUN
ecj-13110	190	114	furthermore	furthermore	ADV
ecj-13110	190	115	,	,	PUNCT
ecj-13110	190	116	skulberg	skulberg	PROPN
ecj-13110	190	117	et	et	PROPN
ecj-13110	190	118	al	al	PROPN
ecj-13110	190	119	.	.	PUNCT
ecj-13110	191	1	(	(	PUNCT
ecj-13110	191	2	2018)13	2018)13	NUM
ecj-13110	191	3	emphasized	emphasize	VERB
ecj-13110	191	4	that	that	SCONJ
ecj-13110	191	5	a	a	DET
ecj-13110	191	6	targetcontrolled	targetcontrolle	VERB
ecj-13110	191	7	infusion	infusion	NOUN
ecj-13110	191	8	of	of	ADP
ecj-13110	191	9	remifentanil	remifentanil	NOUN
ecj-13110	191	10	serves	serve	VERB
ecj-13110	191	11	as	as	ADP
ecj-13110	191	12	an	an	DET
ecj-13110	191	13	effective	effective	ADJ
ecj-13110	191	14	model	model	NOUN
ecj-13110	191	15	for	for	ADP
ecj-13110	191	16	studying	study	VERB
ecj-13110	191	17	naloxone	naloxone	ADJ
ecj-13110	191	18	pharmacodynamics	pharmacodynamic	NOUN
ecj-13110	191	19	.	.	PUNCT
ecj-13110	192	1	their	their	PRON
ecj-13110	192	2	findings	finding	NOUN
ecj-13110	192	3	indicated	indicate	VERB
ecj-13110	192	4	that	that	SCONJ
ecj-13110	192	5	0.8	0.8	NUM
ecj-13110	192	6	mg	mg	NOUN
ecj-13110	192	7	of	of	ADP
ecj-13110	192	8	naloxone	naloxone	NOUN
ecj-13110	192	9	administered	administer	VERB
ecj-13110	192	10	intramuscularly	intramuscularly	ADV
ecj-13110	192	11	had	have	VERB
ecj-13110	192	12	a	a	DET
ecj-13110	192	13	more	more	ADV
ecj-13110	192	14	rapid	rapid	ADJ
ecj-13110	192	15	and	and	CCONJ
ecj-13110	192	16	pronounced	pronounced	ADJ
ecj-13110	192	17	effect	effect	NOUN
ecj-13110	192	18	compared	compare	VERB
ecj-13110	192	19	to	to	ADP
ecj-13110	192	20	the	the	DET
ecj-13110	192	21	same	same	ADJ
ecj-13110	192	22	dose	dose	NOUN
ecj-13110	192	23	administered	administer	VERB
ecj-13110	192	24	intranasally	intranasally	ADV
ecj-13110	192	25	.	.	PUNCT
ecj-13110	193	1	despite	despite	SCONJ
ecj-13110	193	2	the	the	DET
ecj-13110	193	3	lower	low	ADJ
ecj-13110	193	4	intranasal	intranasal	ADJ
ecj-13110	193	5	bioavailability	bioavailability	NOUN
ecj-13110	193	6	,	,	PUNCT
ecj-13110	193	7	in	in	ADP
ecj-13110	193	8	naloxone	naloxone	NOUN
ecj-13110	193	9	can	can	AUX
ecj-13110	193	10	still	still	ADV
ecj-13110	193	11	be	be	AUX
ecj-13110	193	12	advantageous	advantageous	ADJ
ecj-13110	193	13	for	for	ADP
ecj-13110	193	14	reducing	reduce	VERB
ecj-13110	193	15	withdrawal	withdrawal	NOUN
ecj-13110	193	16	symptoms	symptom	NOUN
ecj-13110	193	17	,	,	PUNCT
ecj-13110	193	18	primarily	primarily	ADV
ecj-13110	193	19	due	due	ADP
ecj-13110	193	20	to	to	ADP
ecj-13110	193	21	its	its	PRON
ecj-13110	193	22	ease	ease	NOUN
ecj-13110	193	23	of	of	ADP
ecj-13110	193	24	administration	administration	NOUN
ecj-13110	193	25	in	in	ADP
ecj-13110	193	26	emergency	emergency	NOUN
ecj-13110	193	27	situations	situation	NOUN
ecj-13110	193	28	.	.	PUNCT
ecj-13110	194	1	however	however	ADV
ecj-13110	194	2	,	,	PUNCT
ecj-13110	194	3	it	it	PRON
ecj-13110	194	4	is	be	AUX
ecj-13110	194	5	important	important	ADJ
ecj-13110	194	6	to	to	PART
ecj-13110	194	7	consider	consider	VERB
ecj-13110	194	8	the	the	DET
ecj-13110	194	9	slower	slow	ADJ
ecj-13110	194	10	absorption	absorption	NOUN
ecj-13110	194	11	of	of	ADP
ecj-13110	194	12	in	in	ADP
ecj-13110	194	13	naloxone	naloxone	NOUN
ecj-13110	194	14	and	and	CCONJ
ecj-13110	194	15	its	its	PRON
ecj-13110	194	16	implications	implication	NOUN
ecj-13110	194	17	for	for	ADP
ecj-13110	194	18	the	the	DET
ecj-13110	194	19	timely	timely	ADJ
ecj-13110	194	20	management	management	NOUN
ecj-13110	194	21	of	of	ADP
ecj-13110	194	22	opioid	opioid	PROPN
ecj-13110	194	23	overdose.23	overdose.23	PROPN
ecj-13110	194	24	despite	despite	SCONJ
ecj-13110	194	25	the	the	DET
ecj-13110	194	26	lower	low	ADJ
ecj-13110	194	27	bioavailability	bioavailability	NOUN
ecj-13110	194	28	of	of	ADP
ecj-13110	194	29	in	in	ADP
ecj-13110	194	30	naloxone	naloxone	NOUN
ecj-13110	194	31	,	,	PUNCT
ecj-13110	194	32	in	in	ADP
ecj-13110	194	33	cases	case	NOUN
ecj-13110	194	34	of	of	ADP
ecj-13110	194	35	shock	shock	NOUN
ecj-13110	194	36	,	,	PUNCT
ecj-13110	194	37	the	the	DET
ecj-13110	194	38	i	i	PROPN
ecj-13110	194	39	m	m	PROPN
ecj-13110	194	40	route	route	NOUN
ecj-13110	194	41	may	may	AUX
ecj-13110	194	42	also	also	ADV
ecj-13110	194	43	encounter	encounter	VERB
ecj-13110	194	44	similar	similar	ADJ
ecj-13110	194	45	issues	issue	NOUN
ecj-13110	194	46	related	relate	VERB
ecj-13110	194	47	to	to	ADP
ecj-13110	194	48	compromised	compromise	VERB
ecj-13110	194	49	circulation	circulation	NOUN
ecj-13110	194	50	.	.	PUNCT
ecj-13110	195	1	in	in	ADP
ecj-13110	195	2	patients	patient	NOUN
ecj-13110	195	3	with	with	ADP
ecj-13110	195	4	severe	severe	ADJ
ecj-13110	195	5	opioid	opioid	ADJ
ecj-13110	195	6	intoxication	intoxication	NOUN
ecj-13110	195	7	or	or	CCONJ
ecj-13110	195	8	shock	shock	NOUN
ecj-13110	195	9	,	,	PUNCT
ecj-13110	195	10	both	both	DET
ecj-13110	195	11	routes	route	NOUN
ecj-13110	195	12	can	can	AUX
ecj-13110	195	13	be	be	AUX
ecj-13110	195	14	less	less	ADV
ecj-13110	195	15	effective	effective	ADJ
ecj-13110	195	16	due	due	ADJ
ecj-13110	195	17	to	to	ADP
ecj-13110	195	18	reduced	reduce	VERB
ecj-13110	195	19	absorption	absorption	NOUN
ecj-13110	195	20	caused	cause	VERB
ecj-13110	195	21	by	by	ADP
ecj-13110	195	22	hypotension	hypotension	NOUN
ecj-13110	195	23	and	and	CCONJ
ecj-13110	195	24	vasoconstriction	vasoconstriction	NOUN
ecj-13110	195	25	,	,	PUNCT
ecj-13110	195	26	which	which	PRON
ecj-13110	195	27	affect	affect	VERB
ecj-13110	195	28	circulation	circulation	NOUN
ecj-13110	195	29	.	.	PUNCT
ecj-13110	196	1	this	this	DET
ecj-13110	196	2	highlights	highlight	VERB
ecj-13110	196	3	the	the	DET
ecj-13110	196	4	complexity	complexity	NOUN
ecj-13110	196	5	of	of	ADP
ecj-13110	196	6	naloxone	naloxone	ADJ
ecj-13110	196	7	administration	administration	NOUN
ecj-13110	196	8	in	in	ADP
ecj-13110	196	9	such	such	ADJ
ecj-13110	196	10	critical	critical	ADJ
ecj-13110	196	11	conditions	condition	NOUN
ecj-13110	196	12	,	,	PUNCT
ecj-13110	196	13	where	where	SCONJ
ecj-13110	196	14	both	both	PRON
ecj-13110	196	15	i	i	PRON
ecj-13110	196	16	m	m	VERB
ecj-13110	196	17	and	and	CCONJ
ecj-13110	196	18	in	in	ADP
ecj-13110	196	19	routes	route	NOUN
ecj-13110	196	20	may	may	AUX
ecj-13110	196	21	face	face	VERB
ecj-13110	196	22	challenges	challenge	NOUN
ecj-13110	196	23	in	in	ADP
ecj-13110	196	24	ensuring	ensure	VERB
ecj-13110	196	25	optimal	optimal	ADJ
ecj-13110	196	26	drug	drug	NOUN
ecj-13110	196	27	absorption	absorption	NOUN
ecj-13110	196	28	.	.	PUNCT
ecj-13110	197	1	additionally	additionally	ADV
ecj-13110	197	2	,	,	PUNCT
ecj-13110	197	3	intranasal	intranasal	ADJ
ecj-13110	197	4	naloxone	naloxone	NOUN
ecj-13110	197	5	offers	offer	VERB
ecj-13110	197	6	an	an	DET
ecj-13110	197	7	important	important	ADJ
ecj-13110	197	8	pharmacokinetic	pharmacokinetic	ADJ
ecj-13110	197	9	advantage	advantage	NOUN
ecj-13110	197	10	:	:	PUNCT
ecj-13110	197	11	it	it	PRON
ecj-13110	197	12	enters	enter	VERB
ecj-13110	197	13	the	the	DET
ecj-13110	197	14	central	central	ADJ
ecj-13110	197	15	venous	venous	ADJ
ecj-13110	197	16	circulation	circulation	NOUN
ecj-13110	197	17	immediately	immediately	ADV
ecj-13110	197	18	,	,	PUNCT
ecj-13110	197	19	bypassing	bypass	VERB
ecj-13110	197	20	the	the	DET
ecj-13110	197	21	first	first	ADJ
ecj-13110	197	22	hepatic	hepatic	ADJ
ecj-13110	197	23	pass	pass	NOUN
ecj-13110	197	24	and	and	CCONJ
ecj-13110	197	25	exploiting	exploit	VERB
ecj-13110	197	26	the	the	DET
ecj-13110	197	27	highly	highly	ADV
ecj-13110	197	28	vascularized	vascularized	ADJ
ecj-13110	197	29	mucosa	mucosa	NOUN
ecj-13110	197	30	in	in	ADP
ecj-13110	197	31	the	the	DET
ecj-13110	197	32	nasal	nasal	ADJ
ecj-13110	197	33	cavity	cavity	NOUN
ecj-13110	197	34	.	.	PUNCT
ecj-13110	198	1	this	this	PRON
ecj-13110	198	2	allows	allow	VERB
ecj-13110	198	3	for	for	ADP
ecj-13110	198	4	faster	fast	ADJ
ecj-13110	198	5	systemic	systemic	ADJ
ecj-13110	198	6	absorption	absorption	NOUN
ecj-13110	198	7	compared	compare	VERB
ecj-13110	198	8	to	to	ADP
ecj-13110	198	9	intramuscular	intramuscular	ADJ
ecj-13110	198	10	administration	administration	NOUN
ecj-13110	198	11	.	.	PUNCT
ecj-13110	199	1	moreover	moreover	ADV
ecj-13110	199	2	,	,	PUNCT
ecj-13110	199	3	absorption	absorption	NOUN
ecj-13110	199	4	at	at	ADP
ecj-13110	199	5	the	the	DET
ecj-13110	199	6	level	level	NOUN
ecj-13110	199	7	of	of	ADP
ecj-13110	199	8	the	the	DET
ecj-13110	199	9	olfactory	olfactory	ADJ
ecj-13110	199	10	mucosa	mucosa	NOUN
ecj-13110	199	11	can	can	AUX
ecj-13110	199	12	facilitate	facilitate	VERB
ecj-13110	199	13	the	the	DET
ecj-13110	199	14	immediate	immediate	ADJ
ecj-13110	199	15	passage	passage	NOUN
ecj-13110	199	16	of	of	ADP
ecj-13110	199	17	naloxone	naloxone	NOUN
ecj-13110	199	18	into	into	ADP
ecj-13110	199	19	the	the	DET
ecj-13110	199	20	central	central	ADJ
ecj-13110	199	21	nervous	nervous	ADJ
ecj-13110	199	22	system	system	NOUN
ecj-13110	199	23	,	,	PUNCT
ecj-13110	199	24	which	which	PRON
ecj-13110	199	25	is	be	AUX
ecj-13110	199	26	particularly	particularly	ADV
ecj-13110	199	27	beneficial	beneficial	ADJ
ecj-13110	199	28	in	in	ADP
ecj-13110	199	29	the	the	DET
ecj-13110	199	30	rapid	rapid	ADJ
ecj-13110	199	31	reversal	reversal	NOUN
ecj-13110	199	32	of	of	ADP
ecj-13110	199	33	opioid	opioid	ADJ
ecj-13110	199	34	toxicity.24	toxicity.24	NOUN
ecj-13110	199	35	skulberg	skulberg	PROPN
ecj-13110	199	36	et	et	PROPN
ecj-13110	199	37	al	al	PROPN
ecj-13110	199	38	.	.	PUNCT
ecj-13110	200	1	(	(	PUNCT
ecj-13110	200	2	2019)15	2019)15	NUM
ecj-13110	200	3	highlighted	highlight	VERB
ecj-13110	200	4	that	that	SCONJ
ecj-13110	200	5	the	the	DET
ecj-13110	200	6	absorption	absorption	NOUN
ecj-13110	200	7	of	of	ADP
ecj-13110	200	8	0.8	0.8	NUM
ecj-13110	200	9	mg	mg	PROPN
ecj-13110	200	10	naloxone	naloxone	NOUN
ecj-13110	201	1	i	i	PRON
ecj-13110	201	2	m	m	VERB
ecj-13110	201	3	was	be	AUX
ecj-13110	201	4	slightly	slightly	ADV
ecj-13110	201	5	faster	fast	ADJ
ecj-13110	201	6	than	than	ADP
ecj-13110	201	7	that	that	PRON
ecj-13110	201	8	of	of	ADP
ecj-13110	201	9	1.4	1.4	NUM
ecj-13110	201	10	mg	mg	NOUN
ecj-13110	201	11	naloxone	naloxone	NOUN
ecj-13110	201	12	in	in	ADP
ecj-13110	201	13	,	,	PUNCT
ecj-13110	201	14	with	with	ADP
ecj-13110	201	15	no	no	DET
ecj-13110	201	16	significant	significant	ADJ
ecj-13110	201	17	differences	difference	NOUN
ecj-13110	201	18	in	in	ADP
ecj-13110	201	19	cmax	cmax	NOUN
ecj-13110	201	20	,	,	PUNCT
ecj-13110	201	21	tmax	tmax	ADV
ecj-13110	201	22	,	,	PUNCT
ecj-13110	201	23	or	or	CCONJ
ecj-13110	201	24	auc0	auc0	NOUN
ecj-13110	201	25	-	-	PUNCT
ecj-13110	201	26	last	last	ADJ
ecj-13110	201	27	between	between	ADP
ecj-13110	201	28	the	the	DET
ecj-13110	201	29	two	two	NUM
ecj-13110	201	30	routes	route	NOUN
ecj-13110	201	31	.	.	PUNCT
ecj-13110	202	1	the	the	DET
ecj-13110	202	2	linear	linear	ADJ
ecj-13110	202	3	increase	increase	NOUN
ecj-13110	202	4	in	in	ADP
ecj-13110	202	5	systemic	systemic	ADJ
ecj-13110	202	6	exposure	exposure	NOUN
ecj-13110	202	7	with	with	ADP
ecj-13110	202	8	intranasal	intranasal	ADJ
ecj-13110	202	9	doses	dose	NOUN
ecj-13110	202	10	suggests	suggest	VERB
ecj-13110	202	11	that	that	SCONJ
ecj-13110	202	12	in	in	ADP
ecj-13110	202	13	naloxone	naloxone	NOUN
ecj-13110	202	14	is	be	AUX
ecj-13110	202	15	suitable	suitable	ADJ
ecj-13110	202	16	for	for	ADP
ecj-13110	202	17	repeated	repeat	VERB
ecj-13110	202	18	administrations.25	administrations.25	ADJ
ecj-13110	202	19	new	new	ADJ
ecj-13110	202	20	naloxone	naloxone	NOUN
ecj-13110	202	21	formulations	formulation	NOUN
ecj-13110	202	22	,	,	PUNCT
ecj-13110	202	23	such	such	ADJ
ecj-13110	202	24	as	as	ADP
ecj-13110	202	25	nyxoid	nyxoid	NOUN
ecj-13110	202	26	and	and	CCONJ
ecj-13110	202	27	narcan	narcan	ADJ
ecj-13110	202	28	nasal	nasal	NOUN
ecj-13110	202	29	,	,	PUNCT
ecj-13110	202	30	exhibit	exhibit	VERB
ecj-13110	202	31	similar	similar	ADJ
ecj-13110	202	32	pharmacokinetic	pharmacokinetic	ADJ
ecj-13110	202	33	profiles	profile	NOUN
ecj-13110	202	34	and	and	CCONJ
ecj-13110	202	35	offer	offer	VERB
ecj-13110	202	36	higher	high	ADJ
ecj-13110	202	37	serum	serum	NOUN
ecj-13110	202	38	concentrations	concentration	NOUN
ecj-13110	202	39	than	than	ADP
ecj-13110	202	40	those	those	PRON
ecj-13110	202	41	achieved	achieve	VERB
ecj-13110	202	42	with	with	ADP
ecj-13110	202	43	0.4	0.4	NUM
ecj-13110	202	44	mg	mg	PROPN
ecj-13110	202	45	i	i	PRON
ecj-13110	202	46	m.	m.	NOUN
ecj-13110	202	47	when	when	SCONJ
ecj-13110	202	48	administered	administer	VERB
ecj-13110	202	49	2.25	2.25	NUM
ecj-13110	202	50	minutes	minute	NOUN
ecj-13110	202	51	prior	prior	ADV
ecj-13110	202	52	to	to	ADP
ecj-13110	202	53	an	an	DET
ecj-13110	202	54	i	i	PROPN
ecj-13110	202	55	m	m	PROPN
ecj-13110	202	56	dose	dose	VERB
ecj-13110	202	57	,	,	PUNCT
ecj-13110	202	58	1.4	1.4	NUM
ecj-13110	202	59	mg	mg	NOUN
ecj-13110	202	60	in	in	ADP
ecj-13110	202	61	naloxone	naloxone	NOUN
ecj-13110	202	62	can	can	AUX
ecj-13110	202	63	still	still	ADV
ecj-13110	202	64	provide	provide	VERB
ecj-13110	202	65	higher	high	ADJ
ecj-13110	202	66	blood	blood	NOUN
ecj-13110	202	67	concentrations	concentration	NOUN
ecj-13110	202	68	,	,	PUNCT
ecj-13110	202	69	indicating	indicate	VERB
ecj-13110	202	70	a	a	DET
ecj-13110	202	71	clinical	clinical	ADJ
ecj-13110	202	72	benefit.26	benefit.26	ADJ
ecj-13110	202	73	dietze	dietze	NOUN
ecj-13110	202	74	et	et	PROPN
ecj-13110	202	75	al.14	al.14	PROPN
ecj-13110	202	76	confirmed	confirm	VERB
ecj-13110	202	77	that	that	SCONJ
ecj-13110	202	78	while	while	SCONJ
ecj-13110	202	79	intranasal	intranasal	ADJ
ecj-13110	202	80	naloxone	naloxone	NOUN
ecj-13110	202	81	is	be	AUX
ecj-13110	202	82	less	less	ADV
ecj-13110	202	83	effective	effective	ADJ
ecj-13110	202	84	than	than	ADP
ecj-13110	202	85	intramuscular	intramuscular	ADJ
ecj-13110	202	86	naloxone	naloxone	NOUN
ecj-13110	202	87	at	at	ADP
ecj-13110	202	88	equivalent	equivalent	ADJ
ecj-13110	202	89	doses	dose	NOUN
ecj-13110	202	90	,	,	PUNCT
ecj-13110	202	91	it	it	PRON
ecj-13110	202	92	offers	offer	VERB
ecj-13110	202	93	several	several	ADJ
ecj-13110	202	94	advantages	advantage	NOUN
ecj-13110	202	95	,	,	PUNCT
ecj-13110	202	96	including	include	VERB
ecj-13110	202	97	the	the	DET
ecj-13110	202	98	elimination	elimination	NOUN
ecj-13110	202	99	of	of	ADP
ecj-13110	202	100	accidental	accidental	ADJ
ecj-13110	202	101	needle	needle	PROPN
ecj-13110	202	102	stick	stick	PROPN
ecj-13110	202	103	injuries	injury	NOUN
ecj-13110	202	104	and	and	CCONJ
ecj-13110	202	105	the	the	DET
ecj-13110	202	106	need	need	NOUN
ecj-13110	202	107	for	for	ADP
ecj-13110	202	108	less	less	ADV
ecj-13110	202	109	extensive	extensive	ADJ
ecj-13110	202	110	training	training	NOUN
ecj-13110	202	111	.	.	PUNCT
ecj-13110	203	1	these	these	DET
ecj-13110	203	2	benefits	benefit	NOUN
ecj-13110	203	3	support	support	VERB
ecj-13110	203	4	public	public	ADJ
ecj-13110	203	5	health	health	NOUN
ecj-13110	203	6	policies	policy	NOUN
ecj-13110	203	7	aimed	aim	VERB
ecj-13110	203	8	at	at	ADP
ecj-13110	203	9	expanding	expand	VERB
ecj-13110	203	10	immediate	immediate	ADJ
ecj-13110	203	11	access	access	NOUN
ecj-13110	203	12	and	and	CCONJ
ecj-13110	203	13	use	use	NOUN
ecj-13110	203	14	of	of	ADP
ecj-13110	203	15	naloxone	naloxone	NOUN
ecj-13110	203	16	by	by	ADP
ecj-13110	203	17	both	both	CCONJ
ecj-13110	203	18	laypeople	laypeople	NOUN
ecj-13110	203	19	and	and	CCONJ
ecj-13110	203	20	first	first	ADJ
ecj-13110	203	21	responders	responder	NOUN
ecj-13110	203	22	in	in	ADP
ecj-13110	203	23	community	community	NOUN
ecj-13110	203	24	settings.27	settings.27	PROPN
ecj-13110	203	25	-	-	PROPN
ecj-13110	203	26	29	29	NUM
ecj-13110	203	27	however	however	ADV
ecj-13110	203	28	,	,	PUNCT
ecj-13110	203	29	further	further	ADJ
ecj-13110	203	30	research	research	NOUN
ecj-13110	203	31	is	be	AUX
ecj-13110	203	32	required	require	VERB
ecj-13110	203	33	to	to	PART
ecj-13110	203	34	determine	determine	VERB
ecj-13110	203	35	whether	whether	SCONJ
ecj-13110	203	36	higher	high	ADJ
ecj-13110	203	37	doses	dose	NOUN
ecj-13110	203	38	of	of	ADP
ecj-13110	203	39	in	in	ADP
ecj-13110	203	40	naloxone	naloxone	NOUN
ecj-13110	203	41	could	could	AUX
ecj-13110	203	42	achieve	achieve	VERB
ecj-13110	203	43	the	the	DET
ecj-13110	203	44	same	same	ADJ
ecj-13110	203	45	level	level	NOUN
ecj-13110	203	46	of	of	ADP
ecj-13110	203	47	efficacy	efficacy	NOUN
ecj-13110	203	48	as	as	ADP
ecj-13110	203	49	i	i	PROPN
ecj-13110	203	50	m	m	VERB
ecj-13110	203	51	administration.29	administration.29	ADJ
ecj-13110	203	52	skulberg	skulberg	PROPN
ecj-13110	203	53	et	et	PROPN
ecj-13110	203	54	al	al	PROPN
ecj-13110	203	55	.	.	PUNCT
ecj-13110	204	1	(	(	PUNCT
ecj-13110	204	2	2022)13	2022)13	NUM
ecj-13110	204	3	found	find	VERB
ecj-13110	204	4	that	that	SCONJ
ecj-13110	204	5	a	a	DET
ecj-13110	204	6	single	single	ADJ
ecj-13110	204	7	1.4	1.4	NUM
ecj-13110	204	8	mg	mg	NOUN
ecj-13110	204	9	in	in	ADP
ecj-13110	204	10	dose	dose	PROPN
ecj-13110	204	11	of	of	ADP
ecj-13110	204	12	naloxone	naloxone	NOUN
ecj-13110	204	13	was	be	AUX
ecj-13110	204	14	less	less	ADV
ecj-13110	204	15	effective	effective	ADJ
ecj-13110	204	16	than	than	ADP
ecj-13110	204	17	0.8	0.8	NUM
ecj-13110	204	18	mg	mg	PROPN
ecj-13110	205	1	i	i	PRON
ecj-13110	205	2	m	m	VERB
ecj-13110	205	3	naloxone	naloxone	ADJ
ecj-13110	205	4	in	in	ADP
ecj-13110	205	5	achieving	achieve	VERB
ecj-13110	205	6	spontaneous	spontaneous	ADJ
ecj-13110	205	7	respiration	respiration	NOUN
ecj-13110	205	8	within	within	ADP
ecj-13110	205	9	10	10	NUM
ecj-13110	205	10	minutes	minute	NOUN
ecj-13110	205	11	of	of	ADP
ecj-13110	205	12	administration	administration	NOUN
ecj-13110	205	13	.	.	PUNCT
ecj-13110	206	1	nevertheless	nevertheless	ADV
ecj-13110	206	2	,	,	PUNCT
ecj-13110	206	3	in	in	ADP
ecj-13110	206	4	naloxone	naloxone	NOUN
ecj-13110	206	5	exhibited	exhibit	VERB
ecj-13110	206	6	slower	slow	ADJ
ecj-13110	206	7	absorption	absorption	NOUN
ecj-13110	206	8	,	,	PUNCT
ecj-13110	206	9	which	which	PRON
ecj-13110	206	10	may	may	AUX
ecj-13110	206	11	reduce	reduce	VERB
ecj-13110	206	12	the	the	DET
ecj-13110	206	13	risk	risk	NOUN
ecj-13110	206	14	of	of	ADP
ecj-13110	206	15	withdrawal	withdrawal	NOUN
ecj-13110	206	16	symptoms	symptom	NOUN
ecj-13110	206	17	.	.	PUNCT
ecj-13110	207	1	while	while	SCONJ
ecj-13110	207	2	i	i	PRON
ecj-13110	207	3	m	m	PROPN
ecj-13110	207	4	formulations	formulation	NOUN
ecj-13110	207	5	have	have	VERB
ecj-13110	207	6	a	a	DET
ecj-13110	207	7	faster	fast	ADJ
ecj-13110	207	8	onset	onset	NOUN
ecj-13110	207	9	,	,	PUNCT
ecj-13110	207	10	they	they	PRON
ecj-13110	207	11	are	be	AUX
ecj-13110	207	12	associated	associate	VERB
ecj-13110	207	13	with	with	ADP
ecj-13110	207	14	a	a	DET
ecj-13110	207	15	higher	high	ADJ
ecj-13110	207	16	risk	risk	NOUN
ecj-13110	207	17	of	of	ADP
ecj-13110	207	18	adverse	adverse	ADJ
ecj-13110	207	19	reactions.3133	reactions.3133	PROPN
ecj-13110	207	20	given	give	VERB
ecj-13110	207	21	the	the	DET
ecj-13110	207	22	increasing	increase	VERB
ecj-13110	207	23	prevalence	prevalence	NOUN
ecj-13110	207	24	of	of	ADP
ecj-13110	207	25	synthetic	synthetic	ADJ
ecj-13110	207	26	opioids	opioid	NOUN
ecj-13110	207	27	,	,	PUNCT
ecj-13110	207	28	including	include	VERB
ecj-13110	207	29	illicitly	illicitly	ADV
ecj-13110	207	30	manufactured	manufacture	VERB
ecj-13110	207	31	fentanyl	fentanyl	ADJ
ecj-13110	207	32	and	and	CCONJ
ecj-13110	207	33	fentanyl	fentanyl	NOUN
ecj-13110	207	34	analogs	analog	NOUN
ecj-13110	207	35	(	(	PUNCT
ecj-13110	207	36	f	f	X
ecj-13110	207	37	/	/	SYM
ecj-13110	207	38	fa),34	fa),34	PROPN
ecj-13110	207	39	it	it	PRON
ecj-13110	207	40	is	be	AUX
ecj-13110	207	41	critical	critical	ADJ
ecj-13110	207	42	to	to	PART
ecj-13110	207	43	evaluate	evaluate	VERB
ecj-13110	207	44	the	the	DET
ecj-13110	207	45	efficacy	efficacy	NOUN
ecj-13110	207	46	and	and	CCONJ
ecj-13110	207	47	optimal	optimal	ADJ
ecj-13110	207	48	dosage	dosage	NOUN
ecj-13110	207	49	of	of	ADP
ecj-13110	207	50	both	both	PRON
ecj-13110	207	51	in	in	ADP
ecj-13110	207	52	and	and	CCONJ
ecj-13110	207	53	i	i	PRON
ecj-13110	207	54	m	m	VERB
ecj-13110	207	55	naloxone	naloxone	ADJ
ecj-13110	207	56	formulations	formulation	NOUN
ecj-13110	207	57	in	in	ADP
ecj-13110	207	58	reversing	reverse	VERB
ecj-13110	207	59	overdoses	overdose	NOUN
ecj-13110	207	60	caused	cause	VERB
ecj-13110	207	61	by	by	ADP
ecj-13110	207	62	these	these	DET
ecj-13110	207	63	substances	substance	NOUN
ecj-13110	207	64	.	.	PUNCT
ecj-13110	208	1	in	in	ADP
ecj-13110	208	2	emergency	emergency	NOUN
ecj-13110	208	3	situations	situation	NOUN
ecj-13110	208	4	,	,	PUNCT
ecj-13110	208	5	it	it	PRON
ecj-13110	208	6	is	be	AUX
ecj-13110	208	7	often	often	ADV
ecj-13110	208	8	not	not	PART
ecj-13110	208	9	possible	possible	ADJ
ecj-13110	208	10	to	to	PART
ecj-13110	208	11	distinguish	distinguish	VERB
ecj-13110	208	12	between	between	ADP
ecj-13110	208	13	overdoses	overdose	NOUN
ecj-13110	208	14	caused	cause	VERB
ecj-13110	208	15	by	by	ADP
ecj-13110	208	16	prescription	prescription	NOUN
ecj-13110	208	17	opioids	opioid	NOUN
ecj-13110	208	18	,	,	PUNCT
ecj-13110	208	19	synthetic	synthetic	ADJ
ecj-13110	208	20	opioids	opioid	NOUN
ecj-13110	208	21	,	,	PUNCT
ecj-13110	208	22	and	and	CCONJ
ecj-13110	208	23	fentanyl.35	fentanyl.35	NOUN
ecj-13110	208	24	limitations	limitation	NOUN
ecj-13110	208	25	the	the	DET
ecj-13110	208	26	limitations	limitation	NOUN
ecj-13110	208	27	of	of	ADP
ecj-13110	208	28	this	this	DET
ecj-13110	208	29	review	review	NOUN
ecj-13110	208	30	stem	stem	VERB
ecj-13110	208	31	primarily	primarily	ADV
ecj-13110	208	32	from	from	ADP
ecj-13110	208	33	the	the	DET
ecj-13110	208	34	small	small	ADJ
ecj-13110	208	35	number	number	NOUN
ecj-13110	208	36	of	of	ADP
ecj-13110	208	37	studies	study	NOUN
ecj-13110	208	38	included	include	VERB
ecj-13110	208	39	and	and	CCONJ
ecj-13110	208	40	the	the	DET
ecj-13110	208	41	use	use	NOUN
ecj-13110	208	42	of	of	ADP
ecj-13110	208	43	a	a	DET
ecj-13110	208	44	single	single	ADJ
ecj-13110	208	45	database	database	NOUN
ecj-13110	208	46	,	,	PUNCT
ecj-13110	208	47	pubmed	pubmed	PROPN
ecj-13110	208	48	.	.	PUNCT
ecj-13110	209	1	the	the	DET
ecj-13110	209	2	search	search	NOUN
ecj-13110	209	3	strategy	strategy	NOUN
ecj-13110	209	4	yielded	yield	VERB
ecj-13110	209	5	111	111	NUM
ecj-13110	209	6	results	result	NOUN
ecj-13110	209	7	,	,	PUNCT
ecj-13110	209	8	but	but	CCONJ
ecj-13110	209	9	only	only	ADV
ecj-13110	209	10	5	5	NUM
ecj-13110	209	11	met	meet	VERB
ecj-13110	209	12	the	the	DET
ecj-13110	209	13	initial	initial	ADJ
ecj-13110	209	14	pico	pico	NOUN
ecj-13110	209	15	criteria	criterion	NOUN
ecj-13110	209	16	and	and	CCONJ
ecj-13110	209	17	demonstrated	demonstrate	VERB
ecj-13110	209	18	robust	robust	ADJ
ecj-13110	209	19	methodological	methodological	ADJ
ecj-13110	209	20	quality	quality	NOUN
ecj-13110	209	21	.	.	PUNCT
ecj-13110	210	1	additionally	additionally	ADV
ecj-13110	210	2	,	,	PUNCT
ecj-13110	210	3	the	the	DET
ecj-13110	210	4	temporal	temporal	ADJ
ecj-13110	210	5	filter	filter	NOUN
ecj-13110	210	6	,	,	PUNCT
ecj-13110	210	7	restricting	restrict	VERB
ecj-13110	210	8	the	the	DET
ecj-13110	210	9	search	search	NOUN
ecj-13110	210	10	to	to	ADP
ecj-13110	210	11	studies	study	NOUN
ecj-13110	210	12	from	from	ADP
ecj-13110	210	13	the	the	DET
ecj-13110	210	14	past	past	ADJ
ecj-13110	210	15	6	6	NUM
ecj-13110	210	16	years	year	NOUN
ecj-13110	210	17	,	,	PUNCT
ecj-13110	210	18	further	far	ADV
ecj-13110	210	19	limited	limit	VERB
ecj-13110	210	20	the	the	DET
ecj-13110	210	21	scope	scope	NOUN
ecj-13110	210	22	.	.	PUNCT
ecj-13110	211	1	despite	despite	SCONJ
ecj-13110	211	2	these	these	DET
ecj-13110	211	3	constraints	constraint	NOUN
ecj-13110	211	4	,	,	PUNCT
ecj-13110	211	5	efforts	effort	NOUN
ecj-13110	211	6	were	be	AUX
ecj-13110	211	7	made	make	VERB
ecj-13110	211	8	to	to	PART
ecj-13110	211	9	identify	identify	VERB
ecj-13110	211	10	other	other	ADJ
ecj-13110	211	11	relevant	relevant	ADJ
ecj-13110	211	12	reviews	review	NOUN
ecj-13110	211	13	,	,	PUNCT
ecj-13110	211	14	including	include	VERB
ecj-13110	211	15	the	the	DET
ecj-13110	211	16	recent	recent	ADJ
ecj-13110	211	17	work	work	NOUN
ecj-13110	211	18	by	by	ADP
ecj-13110	211	19	yousefifard	yousefifard	PROPN
ecj-13110	211	20	et	et	PROPN
ecj-13110	211	21	al	al	PROPN
ecj-13110	211	22	.	.	PROPN
ecj-13110	211	23	,18	,18	PUNCT
ecj-13110	211	24	which	which	PRON
ecj-13110	211	25	covered	cover	VERB
ecj-13110	211	26	studies	study	NOUN
ecj-13110	211	27	excluded	exclude	VERB
ecj-13110	211	28	due	due	ADP
ecj-13110	211	29	to	to	ADP
ecj-13110	211	30	the	the	DET
ecj-13110	211	31	time	time	NOUN
ecj-13110	211	32	filter	filter	NOUN
ecj-13110	211	33	.	.	PUNCT
ecj-13110	212	1	furthermore	furthermore	ADV
ecj-13110	212	2	,	,	PUNCT
ecj-13110	212	3	the	the	DET
ecj-13110	212	4	heterogeneity	heterogeneity	NOUN
ecj-13110	212	5	of	of	ADP
ecj-13110	212	6	the	the	DET
ecj-13110	212	7	populations	population	NOUN
ecj-13110	212	8	included	include	VERB
ecj-13110	212	9	in	in	ADP
ecj-13110	212	10	the	the	DET
ecj-13110	212	11	studies	study	NOUN
ecj-13110	212	12	—	—	PUNCT
ecj-13110	212	13	ranging	range	VERB
ecj-13110	212	14	from	from	ADP
ecj-13110	212	15	healthy	healthy	ADJ
ecj-13110	212	16	volunteers	volunteer	NOUN
ecj-13110	212	17	to	to	ADP
ecj-13110	212	18	patients	patient	NOUN
ecj-13110	212	19	with	with	ADP
ecj-13110	212	20	active	active	ADJ
ecj-13110	212	21	opioid	opioid	ADJ
ecj-13110	212	22	use	use	NOUN
ecj-13110	212	23	—	—	PUNCT
ecj-13110	212	24	limits	limit	VERB
ecj-13110	212	25	the	the	DET
ecj-13110	212	26	generalizability	generalizability	NOUN
ecj-13110	212	27	of	of	ADP
ecj-13110	212	28	the	the	DET
ecj-13110	212	29	findings	finding	NOUN
ecj-13110	212	30	and	and	CCONJ
ecj-13110	212	31	highlights	highlight	NOUN
ecj-13110	212	32	the	the	DET
ecj-13110	212	33	need	need	NOUN
ecj-13110	212	34	for	for	ADP
ecj-13110	212	35	further	further	ADJ
ecj-13110	212	36	research	research	NOUN
ecj-13110	212	37	with	with	ADP
ecj-13110	212	38	more	more	ADV
ecj-13110	212	39	homogeneous	homogeneous	ADJ
ecj-13110	212	40	groups	group	NOUN
ecj-13110	212	41	to	to	PART
ecj-13110	212	42	better	well	ADV
ecj-13110	212	43	assess	assess	VERB
ecj-13110	212	44	the	the	DET
ecj-13110	212	45	efficacy	efficacy	NOUN
ecj-13110	212	46	of	of	ADP
ecj-13110	212	47	different	different	ADJ
ecj-13110	212	48	naloxone	naloxone	ADJ
ecj-13110	212	49	formulations	formulation	NOUN
ecj-13110	212	50	in	in	ADP
ecj-13110	212	51	specific	specific	ADJ
ecj-13110	212	52	patient	patient	ADJ
ecj-13110	212	53	populations	population	NOUN
ecj-13110	212	54	.	.	PUNCT
ecj-13110	213	1	review	review	NOUN
ecj-13110	213	2	[	[	X
ecj-13110	213	3	emergency	emergency	NOUN
ecj-13110	213	4	care	care	NOUN
ecj-13110	213	5	journal	journal	NOUN
ecj-13110	213	6	2025	2025	NUM
ecj-13110	213	7	;	;	PUNCT
ecj-13110	213	8	21:13110	21:13110	NUM
ecj-13110	213	9	]	]	X
ecj-13110	214	1	[	[	X
ecj-13110	214	2	page	page	NOUN
ecj-13110	214	3	45	45	NUM
ecj-13110	214	4	]	]	PUNCT
ecj-13110	214	5	conclusions	conclusion	NOUN
ecj-13110	214	6	this	this	DET
ecj-13110	214	7	review	review	NOUN
ecj-13110	214	8	underscores	underscore	VERB
ecj-13110	214	9	that	that	SCONJ
ecj-13110	214	10	intravenous	intravenous	ADJ
ecj-13110	214	11	naloxone	naloxone	NOUN
ecj-13110	214	12	remains	remain	VERB
ecj-13110	214	13	the	the	DET
ecj-13110	214	14	first	first	ADJ
ecj-13110	214	15	-	-	PUNCT
ecj-13110	214	16	line	line	NOUN
ecj-13110	214	17	treatment	treatment	NOUN
ecj-13110	214	18	for	for	ADP
ecj-13110	214	19	opioid	opioid	ADJ
ecj-13110	214	20	overdoses	overdose	NOUN
ecj-13110	214	21	due	due	ADP
ecj-13110	214	22	to	to	ADP
ecj-13110	214	23	its	its	PRON
ecj-13110	214	24	superior	superior	ADJ
ecj-13110	214	25	efficacy	efficacy	NOUN
ecj-13110	214	26	.	.	PUNCT
ecj-13110	215	1	however	however	ADV
ecj-13110	215	2	,	,	PUNCT
ecj-13110	215	3	in	in	ADP
ecj-13110	215	4	prehospital	prehospital	ADJ
ecj-13110	215	5	settings	setting	NOUN
ecj-13110	215	6	,	,	PUNCT
ecj-13110	215	7	where	where	SCONJ
ecj-13110	215	8	establishing	establish	VERB
ecj-13110	215	9	iv	iv	NUM
ecj-13110	215	10	access	access	NOUN
ecj-13110	215	11	is	be	AUX
ecj-13110	215	12	challenging	challenging	ADJ
ecj-13110	215	13	,	,	PUNCT
ecj-13110	216	1	i	i	PRON
ecj-13110	216	2	m	m	VERB
ecj-13110	216	3	and	and	CCONJ
ecj-13110	216	4	in	in	ADP
ecj-13110	216	5	routes	route	NOUN
ecj-13110	216	6	serve	serve	VERB
ecj-13110	216	7	as	as	ADP
ecj-13110	216	8	practical	practical	ADJ
ecj-13110	216	9	alternatives	alternative	NOUN
ecj-13110	216	10	.	.	PUNCT
ecj-13110	217	1	among	among	ADP
ecj-13110	217	2	these	these	PRON
ecj-13110	217	3	,	,	PUNCT
ecj-13110	217	4	i	i	PRON
ecj-13110	217	5	m	m	VERB
ecj-13110	217	6	naloxone	naloxone	NOUN
ecj-13110	217	7	demonstrates	demonstrate	VERB
ecj-13110	217	8	a	a	DET
ecj-13110	217	9	faster	fast	ADJ
ecj-13110	217	10	onset	onset	NOUN
ecj-13110	217	11	of	of	ADP
ecj-13110	217	12	action	action	NOUN
ecj-13110	217	13	,	,	PUNCT
ecj-13110	217	14	while	while	SCONJ
ecj-13110	217	15	in	in	ADP
ecj-13110	217	16	naloxone	naloxone	NOUN
ecj-13110	217	17	offers	offer	VERB
ecj-13110	217	18	the	the	DET
ecj-13110	217	19	advantage	advantage	NOUN
ecj-13110	217	20	of	of	ADP
ecj-13110	217	21	being	be	AUX
ecj-13110	217	22	non	non	ADJ
ecj-13110	217	23	-	-	ADJ
ecj-13110	217	24	invasive	invasive	ADJ
ecj-13110	217	25	and	and	CCONJ
ecj-13110	217	26	easier	easy	ADJ
ecj-13110	217	27	to	to	PART
ecj-13110	217	28	administer	administer	VERB
ecj-13110	217	29	,	,	PUNCT
ecj-13110	217	30	particularly	particularly	ADV
ecj-13110	217	31	by	by	ADP
ecj-13110	217	32	lay	lie	VERB
ecj-13110	217	33	responders	responder	NOUN
ecj-13110	217	34	.	.	PUNCT
ecj-13110	218	1	the	the	DET
ecj-13110	218	2	findings	finding	NOUN
ecj-13110	218	3	suggest	suggest	VERB
ecj-13110	218	4	that	that	SCONJ
ecj-13110	218	5	in	in	ADP
ecj-13110	218	6	naloxone	naloxone	NOUN
ecj-13110	218	7	may	may	AUX
ecj-13110	218	8	achieve	achieve	VERB
ecj-13110	218	9	comparable	comparable	ADJ
ecj-13110	218	10	plasma	plasma	NOUN
ecj-13110	218	11	concentrations	concentration	NOUN
ecj-13110	218	12	to	to	ADP
ecj-13110	218	13	i	i	PRON
ecj-13110	218	14	m	m	VERB
ecj-13110	218	15	naloxone	naloxone	ADJ
ecj-13110	218	16	over	over	ADP
ecj-13110	218	17	time	time	NOUN
ecj-13110	218	18	,	,	PUNCT
ecj-13110	218	19	despite	despite	SCONJ
ecj-13110	218	20	its	its	PRON
ecj-13110	218	21	lower	low	ADJ
ecj-13110	218	22	bioavailability	bioavailability	NOUN
ecj-13110	218	23	,	,	PUNCT
ecj-13110	218	24	and	and	CCONJ
ecj-13110	218	25	highlight	highlight	VERB
ecj-13110	218	26	its	its	PRON
ecj-13110	218	27	potential	potential	NOUN
ecj-13110	218	28	for	for	SCONJ
ecj-13110	218	29	repeated	repeat	VERB
ecj-13110	218	30	administration	administration	NOUN
ecj-13110	218	31	to	to	PART
ecj-13110	218	32	balance	balance	VERB
ecj-13110	218	33	efficacy	efficacy	NOUN
ecj-13110	218	34	and	and	CCONJ
ecj-13110	218	35	safety	safety	NOUN
ecj-13110	218	36	.	.	PUNCT
ecj-13110	219	1	gradual	gradual	ADJ
ecj-13110	219	2	dose	dose	NOUN
ecj-13110	219	3	escalation	escalation	NOUN
ecj-13110	219	4	,	,	PUNCT
ecj-13110	219	5	rather	rather	ADV
ecj-13110	219	6	than	than	ADP
ecj-13110	219	7	a	a	DET
ecj-13110	219	8	single	single	ADJ
ecj-13110	219	9	high	high	ADJ
ecj-13110	219	10	dose	dose	NOUN
ecj-13110	219	11	,	,	PUNCT
ecj-13110	219	12	appears	appear	VERB
ecj-13110	219	13	to	to	PART
ecj-13110	219	14	minimize	minimize	VERB
ecj-13110	219	15	the	the	DET
ecj-13110	219	16	risk	risk	NOUN
ecj-13110	219	17	of	of	ADP
ecj-13110	219	18	severe	severe	ADJ
ecj-13110	219	19	withdrawal	withdrawal	NOUN
ecj-13110	219	20	symptoms	symptom	NOUN
ecj-13110	219	21	,	,	PUNCT
ecj-13110	219	22	aligning	align	VERB
ecj-13110	219	23	with	with	ADP
ecj-13110	219	24	who	who	PRON
ecj-13110	219	25	recommendations	recommendation	NOUN
ecj-13110	219	26	.	.	PUNCT
ecj-13110	220	1	given	give	VERB
ecj-13110	220	2	the	the	DET
ecj-13110	220	3	increasing	increase	VERB
ecj-13110	220	4	prevalence	prevalence	NOUN
ecj-13110	220	5	of	of	ADP
ecj-13110	220	6	synthetic	synthetic	ADJ
ecj-13110	220	7	opioids	opioid	NOUN
ecj-13110	220	8	such	such	ADJ
ecj-13110	220	9	as	as	ADP
ecj-13110	220	10	fentanyl	fentanyl	NOUN
ecj-13110	220	11	,	,	PUNCT
ecj-13110	220	12	this	this	DET
ecj-13110	220	13	review	review	NOUN
ecj-13110	220	14	emphasizes	emphasize	VERB
ecj-13110	220	15	the	the	DET
ecj-13110	220	16	urgent	urgent	ADJ
ecj-13110	220	17	need	need	NOUN
ecj-13110	220	18	for	for	ADP
ecj-13110	220	19	updated	update	VERB
ecj-13110	220	20	clinical	clinical	ADJ
ecj-13110	220	21	guidelines	guideline	NOUN
ecj-13110	220	22	to	to	PART
ecj-13110	220	23	address	address	VERB
ecj-13110	220	24	optimal	optimal	ADJ
ecj-13110	220	25	dosing	dosing	NOUN
ecj-13110	220	26	and	and	CCONJ
ecj-13110	220	27	administration	administration	NOUN
ecj-13110	220	28	routes	route	NOUN
ecj-13110	220	29	for	for	ADP
ecj-13110	220	30	naloxone	naloxone	NOUN
ecj-13110	220	31	in	in	ADP
ecj-13110	220	32	prehospital	prehospital	ADJ
ecj-13110	220	33	settings	setting	NOUN
ecj-13110	220	34	.	.	PUNCT
ecj-13110	221	1	further	further	ADJ
ecj-13110	221	2	research	research	NOUN
ecj-13110	221	3	is	be	AUX
ecj-13110	221	4	crucial	crucial	ADJ
ecj-13110	221	5	to	to	PART
ecj-13110	221	6	evaluate	evaluate	VERB
ecj-13110	221	7	the	the	DET
ecj-13110	221	8	comparative	comparative	ADJ
ecj-13110	221	9	effectiveness	effectiveness	NOUN
ecj-13110	221	10	of	of	ADP
ecj-13110	221	11	in	in	ADP
ecj-13110	222	1	and	and	CCONJ
ecj-13110	222	2	i	i	PRON
ecj-13110	222	3	m	m	VERB
ecj-13110	222	4	formulations	formulation	NOUN
ecj-13110	222	5	in	in	ADP
ecj-13110	222	6	reversing	reverse	VERB
ecj-13110	222	7	overdoses	overdose	NOUN
ecj-13110	222	8	caused	cause	VERB
ecj-13110	222	9	by	by	ADP
ecj-13110	222	10	synthetic	synthetic	ADJ
ecj-13110	222	11	opioids	opioid	NOUN
ecj-13110	222	12	,	,	PUNCT
ecj-13110	222	13	ensuring	ensure	VERB
ecj-13110	222	14	timely	timely	ADJ
ecj-13110	222	15	and	and	CCONJ
ecj-13110	222	16	safe	safe	ADJ
ecj-13110	222	17	interventions	intervention	NOUN
ecj-13110	222	18	.	.	PUNCT
ecj-13110	223	1	references	reference	NOUN
ecj-13110	223	2	1	1	NUM
ecj-13110	223	3	.	.	PUNCT
ecj-13110	223	4	unodc	unodc	ADJ
ecj-13110	223	5	.	.	PUNCT
ecj-13110	224	1	world	world	NOUN
ecj-13110	224	2	drug	drug	PROPN
ecj-13110	224	3	report	report	PROPN
ecj-13110	224	4	2021	2021	NUM
ecj-13110	224	5	.	.	PUNCT
ecj-13110	225	1	united	united	PROPN
ecj-13110	225	2	nations	nations	PROPN
ecj-13110	225	3	office	office	PROPN
ecj-13110	225	4	on	on	ADP
ecj-13110	225	5	drugs	drug	NOUN
ecj-13110	225	6	and	and	CCONJ
ecj-13110	225	7	crime	crime	NOUN
ecj-13110	225	8	.	.	PUNCT
ecj-13110	226	1	available	available	ADJ
ecj-13110	226	2	from	from	ADP
ecj-13110	226	3	:	:	PUNCT
ecj-13110	226	4	https://www	https://www	PROPN
ecj-13110	226	5	.	.	PUNCT
ecj-13110	226	6	unodc.org/unodc/en/data-and-analysis/wdr2021.html	unodc.org/unodc/en/data-and-analysis/wdr2021.html	PROPN
ecj-13110	226	7	2	2	NUM
ecj-13110	226	8	.	.	PUNCT
ecj-13110	226	9	gbd	gbd	NOUN
ecj-13110	226	10	2019	2019	NUM
ecj-13110	226	11	diseases	disease	NOUN
ecj-13110	226	12	and	and	CCONJ
ecj-13110	226	13	injuries	injury	NOUN
ecj-13110	226	14	collaborators	collaborator	NOUN
ecj-13110	226	15	.	.	PUNCT
ecj-13110	227	1	global	global	ADJ
ecj-13110	227	2	burden	burden	NOUN
ecj-13110	227	3	of	of	ADP
ecj-13110	227	4	disease	disease	NOUN
ecj-13110	227	5	study	study	NOUN
ecj-13110	227	6	2019	2019	NUM
ecj-13110	227	7	(	(	PUNCT
ecj-13110	227	8	gbd	gbd	NOUN
ecj-13110	227	9	2019	2019	NUM
ecj-13110	227	10	)	)	PUNCT
ecj-13110	227	11	.	.	PUNCT
ecj-13110	228	1	lancet	lancet	PROPN
ecj-13110	228	2	2020	2020	NUM
ecj-13110	228	3	.	.	PUNCT
ecj-13110	229	1	available	available	ADJ
ecj-13110	229	2	from	from	ADP
ecj-13110	229	3	:	:	PUNCT
ecj-13110	229	4	https://www.thelancet.com/gbd	https://www.thelancet.com/gbd	PROPN
ecj-13110	229	5	3	3	NUM
ecj-13110	229	6	.	.	NOUN
ecj-13110	229	7	presidenza	presidenza	PROPN
ecj-13110	229	8	del	del	PROPN
ecj-13110	229	9	consiglio	consiglio	PROPN
ecj-13110	229	10	dei	dei	PROPN
ecj-13110	229	11	ministri	ministri	PROPN
ecj-13110	229	12	,	,	PUNCT
ecj-13110	229	13	dipartimento	dipartimento	ADP
ecj-13110	229	14	per	per	X
ecj-13110	229	15	le	le	X
ecj-13110	229	16	politiche	politiche	PROPN
ecj-13110	229	17	antidroga	antidroga	PROPN
ecj-13110	229	18	.	.	PUNCT
ecj-13110	230	1	relazione	relazione	NOUN
ecj-13110	230	2	al	al	PROPN
ecj-13110	230	3	parlamento	parlamento	PROPN
ecj-13110	230	4	2022	2022	NUM
ecj-13110	230	5	.	.	PUNCT
ecj-13110	231	1	available	available	ADJ
ecj-13110	231	2	from	from	ADP
ecj-13110	231	3	:	:	PUNCT
ecj-13110	231	4	http://www.politicheantidroga.gov.it	http://www.politicheantidroga.gov.it	PRON
ecj-13110	231	5	4	4	NUM
ecj-13110	231	6	.	.	PUNCT
ecj-13110	232	1	istituto	istituto	PROPN
ecj-13110	232	2	nazionale	nazionale	PROPN
ecj-13110	232	3	di	di	PROPN
ecj-13110	232	4	statistica	statistica	PROPN
ecj-13110	232	5	(	(	PUNCT
ecj-13110	232	6	istat	istat	PROPN
ecj-13110	232	7	)	)	PUNCT
ecj-13110	232	8	.	.	PUNCT
ecj-13110	233	1	official	official	ADJ
ecj-13110	233	2	data	datum	NOUN
ecj-13110	233	3	on	on	ADP
ecj-13110	233	4	mortality	mortality	NOUN
ecj-13110	233	5	causes	cause	NOUN
ecj-13110	233	6	in	in	ADP
ecj-13110	233	7	italy	italy	PROPN
ecj-13110	233	8	including	include	VERB
ecj-13110	233	9	drug	drug	NOUN
ecj-13110	233	10	-	-	PUNCT
ecj-13110	233	11	related	relate	VERB
ecj-13110	233	12	deaths	death	NOUN
ecj-13110	233	13	.	.	PUNCT
ecj-13110	234	1	2021	2021	NUM
ecj-13110	234	2	.	.	PUNCT
ecj-13110	235	1	5	5	NUM
ecj-13110	235	2	.	.	X
ecj-13110	235	3	european	european	ADJ
ecj-13110	235	4	monitoring	monitoring	NOUN
ecj-13110	235	5	centre	centre	NOUN
ecj-13110	235	6	for	for	ADP
ecj-13110	235	7	drugs	drug	NOUN
ecj-13110	235	8	and	and	CCONJ
ecj-13110	235	9	drug	drug	NOUN
ecj-13110	235	10	addiction	addiction	NOUN
ecj-13110	235	11	(	(	PUNCT
ecj-13110	235	12	emcdda	emcdda	PROPN
ecj-13110	235	13	)	)	PUNCT
ecj-13110	235	14	.	.	PUNCT
ecj-13110	236	1	report	report	NOUN
ecj-13110	236	2	on	on	ADP
ecj-13110	236	3	drug	drug	NOUN
ecj-13110	236	4	-	-	PUNCT
ecj-13110	236	5	related	relate	VERB
ecj-13110	236	6	deaths	death	NOUN
ecj-13110	236	7	in	in	ADP
ecj-13110	236	8	europe	europe	PROPN
ecj-13110	236	9	.	.	PUNCT
ecj-13110	237	1	2019	2019	NUM
ecj-13110	237	2	.	.	X
ecj-13110	238	1	6	6	NUM
ecj-13110	238	2	.	.	X
ecj-13110	238	3	world	world	PROPN
ecj-13110	238	4	health	health	PROPN
ecj-13110	238	5	organization	organization	PROPN
ecj-13110	238	6	.	.	PUNCT
ecj-13110	239	1	community	community	NOUN
ecj-13110	239	2	management	management	NOUN
ecj-13110	239	3	of	of	ADP
ecj-13110	239	4	opioid	opioid	ADJ
ecj-13110	239	5	overdose	overdose	NOUN
ecj-13110	240	1	[	[	X
ecj-13110	240	2	internet	internet	NOUN
ecj-13110	240	3	]	]	PUNCT
ecj-13110	240	4	.	.	PUNCT
ecj-13110	241	1	geneva	geneva	PROPN
ecj-13110	241	2	:	:	PUNCT
ecj-13110	241	3	world	world	PROPN
ecj-13110	241	4	health	health	NOUN
ecj-13110	241	5	organization	organization	NOUN
ecj-13110	241	6	;	;	PUNCT
ecj-13110	241	7	2014	2014	NUM
ecj-13110	241	8	.	.	PUNCT
ecj-13110	242	1	available	available	ADJ
ecj-13110	242	2	from	from	ADP
ecj-13110	242	3	:	:	PUNCT
ecj-13110	242	4	https://www.who.int/publications	https://www.who.int/publication	NOUN
ecj-13110	242	5	/i	/i	NOUN
ecj-13110	242	6	/	/	SYM
ecj-13110	242	7	item/9789241548816	item/9789241548816	PROPN
ecj-13110	242	8	7	7	NUM
ecj-13110	242	9	.	.	PUNCT
ecj-13110	243	1	chou	chou	PROPN
ecj-13110	243	2	r	r	PROPN
ecj-13110	243	3	,	,	PUNCT
ecj-13110	243	4	korthuis	korthuis	PROPN
ecj-13110	243	5	pt	pt	PROPN
ecj-13110	243	6	,	,	PUNCT
ecj-13110	243	7	mccarty	mccarty	PROPN
ecj-13110	243	8	d	d	PROPN
ecj-13110	243	9	,	,	PUNCT
ecj-13110	243	10	et	et	PROPN
ecj-13110	243	11	al	al	PROPN
ecj-13110	243	12	.	.	PUNCT
ecj-13110	243	13	management	management	NOUN
ecj-13110	243	14	of	of	ADP
ecj-13110	243	15	suspected	suspect	VERB
ecj-13110	243	16	opioid	opioid	ADJ
ecj-13110	243	17	overdose	overdose	NOUN
ecj-13110	243	18	with	with	ADP
ecj-13110	243	19	naloxone	naloxone	NOUN
ecj-13110	243	20	by	by	ADP
ecj-13110	243	21	emergency	emergency	NOUN
ecj-13110	243	22	medical	medical	PROPN
ecj-13110	243	23	services	service	NOUN
ecj-13110	243	24	personnel	personnel	NOUN
ecj-13110	244	1	[	[	X
ecj-13110	244	2	internet	internet	NOUN
ecj-13110	244	3	]	]	PUNCT
ecj-13110	244	4	.	.	PUNCT
ecj-13110	245	1	rockville	rockville	PROPN
ecj-13110	245	2	(	(	PUNCT
ecj-13110	245	3	md	md	PROPN
ecj-13110	245	4	):	):	PUNCT
ecj-13110	245	5	agency	agency	PROPN
ecj-13110	245	6	for	for	ADP
ecj-13110	245	7	healthcare	healthcare	PROPN
ecj-13110	245	8	research	research	NOUN
ecj-13110	245	9	and	and	CCONJ
ecj-13110	245	10	quality	quality	NOUN
ecj-13110	245	11	(	(	PUNCT
ecj-13110	245	12	us	us	PROPN
ecj-13110	245	13	)	)	PUNCT
ecj-13110	245	14	;	;	PUNCT
ecj-13110	245	15	2017	2017	NUM
ecj-13110	245	16	(	(	PUNCT
ecj-13110	245	17	comparative	comparative	ADJ
ecj-13110	245	18	effectiveness	effectiveness	NOUN
ecj-13110	245	19	reviews	review	NOUN
ecj-13110	245	20	,	,	PUNCT
ecj-13110	245	21	no	no	INTJ
ecj-13110	245	22	.	.	NOUN
ecj-13110	245	23	193	193	NUM
ecj-13110	245	24	)	)	PUNCT
ecj-13110	245	25	.	.	PUNCT
ecj-13110	246	1	available	available	ADJ
ecj-13110	246	2	from	from	ADP
ecj-13110	246	3	:	:	PUNCT
ecj-13110	246	4	https://www.ncbi.nlm.nih.gov/books/nbk487477/	https://www.ncbi.nlm.nih.gov/books/nbk487477/	ADJ
ecj-13110	246	5	8	8	NUM
ecj-13110	246	6	.	.	PUNCT
ecj-13110	247	1	dezfulian	dezfulian	PROPN
ecj-13110	247	2	c	c	PROPN
ecj-13110	247	3	,	,	PUNCT
ecj-13110	247	4	orkin	orkin	PROPN
ecj-13110	247	5	am	am	PROPN
ecj-13110	247	6	,	,	PUNCT
ecj-13110	247	7	maron	maron	PROPN
ecj-13110	247	8	ba	ba	PROPN
ecj-13110	247	9	,	,	PUNCT
ecj-13110	247	10	et	et	PROPN
ecj-13110	247	11	al	al	PROPN
ecj-13110	247	12	.	.	PROPN
ecj-13110	248	1	american	american	PROPN
ecj-13110	248	2	heart	heart	PROPN
ecj-13110	248	3	association	association	PROPN
ecj-13110	248	4	council	council	PROPN
ecj-13110	248	5	on	on	ADP
ecj-13110	248	6	cardiopulmonary	cardiopulmonary	ADJ
ecj-13110	248	7	,	,	PUNCT
ecj-13110	248	8	critical	critical	ADJ
ecj-13110	248	9	care	care	NOUN
ecj-13110	248	10	,	,	PUNCT
ecj-13110	248	11	perioperative	perioperative	ADJ
ecj-13110	248	12	and	and	CCONJ
ecj-13110	248	13	resuscitation	resuscitation	NOUN
ecj-13110	248	14	;	;	PUNCT
ecj-13110	248	15	council	council	NOUN
ecj-13110	248	16	on	on	ADP
ecj-13110	248	17	arteriosclerosis	arteriosclerosis	NOUN
ecj-13110	248	18	,	,	PUNCT
ecj-13110	248	19	thrombosis	thrombosis	NOUN
ecj-13110	248	20	and	and	CCONJ
ecj-13110	248	21	vascular	vascular	ADJ
ecj-13110	248	22	biology	biology	NOUN
ecj-13110	248	23	;	;	PUNCT
ecj-13110	248	24	council	council	NOUN
ecj-13110	248	25	on	on	ADP
ecj-13110	248	26	cardiovascular	cardiovascular	ADJ
ecj-13110	248	27	and	and	CCONJ
ecj-13110	248	28	stroke	stroke	NOUN
ecj-13110	248	29	nursing	nursing	NOUN
ecj-13110	248	30	;	;	PUNCT
ecj-13110	248	31	council	council	NOUN
ecj-13110	248	32	on	on	ADP
ecj-13110	248	33	quality	quality	NOUN
ecj-13110	248	34	of	of	ADP
ecj-13110	248	35	care	care	NOUN
ecj-13110	248	36	and	and	CCONJ
ecj-13110	248	37	outcomes	outcome	NOUN
ecj-13110	248	38	research	research	NOUN
ecj-13110	248	39	;	;	PUNCT
ecj-13110	248	40	and	and	CCONJ
ecj-13110	248	41	council	council	NOUN
ecj-13110	248	42	on	on	ADP
ecj-13110	248	43	clinical	clinical	ADJ
ecj-13110	248	44	cardiology	cardiology	NOUN
ecj-13110	248	45	.	.	PUNCT
ecj-13110	249	1	opioidassociated	opioidassociate	VERB
ecj-13110	249	2	out	out	ADP
ecj-13110	249	3	-	-	PUNCT
ecj-13110	249	4	of	of	ADP
ecj-13110	249	5	-	-	PUNCT
ecj-13110	249	6	hospital	hospital	NOUN
ecj-13110	249	7	cardiac	cardiac	ADJ
ecj-13110	249	8	arrest	arrest	NOUN
ecj-13110	249	9	:	:	PUNCT
ecj-13110	249	10	distinctive	distinctive	ADJ
ecj-13110	249	11	clinical	clinical	ADJ
ecj-13110	249	12	features	feature	NOUN
ecj-13110	249	13	and	and	CCONJ
ecj-13110	249	14	implications	implication	NOUN
ecj-13110	249	15	for	for	ADP
ecj-13110	249	16	health	health	NOUN
ecj-13110	249	17	care	care	NOUN
ecj-13110	249	18	and	and	CCONJ
ecj-13110	249	19	public	public	ADJ
ecj-13110	249	20	responses	response	NOUN
ecj-13110	249	21	:	:	PUNCT
ecj-13110	249	22	a	a	DET
ecj-13110	249	23	scientific	scientific	ADJ
ecj-13110	249	24	statement	statement	NOUN
ecj-13110	249	25	from	from	ADP
ecj-13110	249	26	the	the	DET
ecj-13110	249	27	american	american	PROPN
ecj-13110	249	28	heart	heart	PROPN
ecj-13110	249	29	association	association	PROPN
ecj-13110	249	30	.	.	PUNCT
ecj-13110	250	1	circulation	circulation	NOUN
ecj-13110	250	2	2021;143	2021;143	NUM
ecj-13110	250	3	:	:	PUNCT
ecj-13110	250	4	e836	e836	NOUN
ecj-13110	250	5	-	-	SYM
ecj-13110	250	6	70	70	NUM
ecj-13110	250	7	.	.	PUNCT
ecj-13110	251	1	9	9	NUM
ecj-13110	251	2	.	.	X
ecj-13110	251	3	world	world	PROPN
ecj-13110	251	4	health	health	PROPN
ecj-13110	251	5	organization	organization	NOUN
ecj-13110	251	6	(	(	PUNCT
ecj-13110	251	7	who	who	PRON
ecj-13110	251	8	)	)	PUNCT
ecj-13110	251	9	.	.	PUNCT
ecj-13110	252	1	report	report	NOUN
ecj-13110	252	2	on	on	ADP
ecj-13110	252	3	the	the	DET
ecj-13110	252	4	global	global	ADJ
ecj-13110	252	5	opioid	opioid	ADJ
ecj-13110	252	6	overdose	overdose	NOUN
ecj-13110	252	7	crisis	crisis	NOUN
ecj-13110	252	8	.	.	PUNCT
ecj-13110	253	1	2021	2021	NUM
ecj-13110	253	2	.	.	PUNCT
ecj-13110	254	1	10	10	NUM
ecj-13110	254	2	.	.	PUNCT
ecj-13110	255	1	tricco	tricco	PROPN
ecj-13110	255	2	ac	ac	PROPN
ecj-13110	255	3	,	,	PUNCT
ecj-13110	255	4	lillie	lillie	PROPN
ecj-13110	255	5	e	e	PROPN
ecj-13110	255	6	,	,	PUNCT
ecj-13110	255	7	zarin	zarin	PROPN
ecj-13110	255	8	w	w	PROPN
ecj-13110	255	9	,	,	PUNCT
ecj-13110	255	10	et	et	PROPN
ecj-13110	255	11	al	al	PROPN
ecj-13110	255	12	.	.	PUNCT
ecj-13110	256	1	prisma	prisma	PROPN
ecj-13110	256	2	extension	extension	NOUN
ecj-13110	256	3	for	for	ADP
ecj-13110	256	4	scoping	scope	VERB
ecj-13110	256	5	reviews	review	NOUN
ecj-13110	256	6	(	(	PUNCT
ecj-13110	256	7	prisma	prisma	NOUN
ecj-13110	256	8	-	-	PUNCT
ecj-13110	256	9	scr	scr	NOUN
ecj-13110	256	10	):	):	PUNCT
ecj-13110	256	11	checklist	checklist	NOUN
ecj-13110	256	12	and	and	CCONJ
ecj-13110	256	13	explanation	explanation	NOUN
ecj-13110	256	14	.	.	PUNCT
ecj-13110	257	1	ann	ann	PROPN
ecj-13110	257	2	intern	intern	PROPN
ecj-13110	257	3	med	me	VERB
ecj-13110	257	4	2018;169:467	2018;169:467	NUM
ecj-13110	257	5	-	-	SYM
ecj-13110	257	6	73	73	NUM
ecj-13110	257	7	.	.	PUNCT
ecj-13110	258	1	11	11	NUM
ecj-13110	258	2	.	.	PUNCT
ecj-13110	259	1	green	green	PROPN
ecj-13110	259	2	bn	bn	PROPN
ecj-13110	259	3	,	,	PUNCT
ecj-13110	259	4	johnson	johnson	PROPN
ecj-13110	259	5	cd	cd	PROPN
ecj-13110	259	6	,	,	PUNCT
ecj-13110	259	7	adams	adams	PROPN
ecj-13110	259	8	a.	a.	NOUN
ecj-13110	259	9	writing	write	VERB
ecj-13110	259	10	narrative	narrative	NOUN
ecj-13110	259	11	literature	literature	NOUN
ecj-13110	259	12	reviews	review	NOUN
ecj-13110	259	13	for	for	ADP
ecj-13110	259	14	peer	peer	NOUN
ecj-13110	259	15	-	-	PUNCT
ecj-13110	259	16	reviewed	review	VERB
ecj-13110	259	17	journals	journal	NOUN
ecj-13110	259	18	:	:	PUNCT
ecj-13110	259	19	secrets	secret	NOUN
ecj-13110	259	20	of	of	ADP
ecj-13110	259	21	the	the	DET
ecj-13110	259	22	trade	trade	NOUN
ecj-13110	259	23	.	.	PUNCT
ecj-13110	260	1	j	j	PROPN
ecj-13110	260	2	chiropr	chiropr	PROPN
ecj-13110	260	3	med	med	PROPN
ecj-13110	260	4	2006;5:101	2006;5:101	PROPN
ecj-13110	260	5	-	-	SYM
ecj-13110	260	6	17	17	NUM
ecj-13110	260	7	.	.	PUNCT
ecj-13110	260	8	12	12	NUM
ecj-13110	260	9	.	.	PUNCT
ecj-13110	261	1	dixon	dixon	PROPN
ecj-13110	261	2	-	-	PUNCT
ecj-13110	261	3	woods	woods	PROPN
ecj-13110	261	4	m	m	PROPN
ecj-13110	261	5	,	,	PUNCT
ecj-13110	261	6	cavers	caver	NOUN
ecj-13110	261	7	d	d	PROPN
ecj-13110	261	8	,	,	PUNCT
ecj-13110	261	9	agarwal	agarwal	PROPN
ecj-13110	261	10	s	s	PROPN
ecj-13110	261	11	,	,	PUNCT
ecj-13110	261	12	et	et	PROPN
ecj-13110	261	13	al	al	PROPN
ecj-13110	261	14	.	.	PROPN
ecj-13110	261	15	conducting	conduct	VERB
ecj-13110	261	16	a	a	DET
ecj-13110	261	17	critical	critical	ADJ
ecj-13110	261	18	interpretive	interpretive	ADJ
ecj-13110	261	19	synthesis	synthesis	NOUN
ecj-13110	261	20	of	of	ADP
ecj-13110	261	21	the	the	DET
ecj-13110	261	22	literature	literature	NOUN
ecj-13110	261	23	on	on	ADP
ecj-13110	261	24	access	access	NOUN
ecj-13110	261	25	to	to	ADP
ecj-13110	261	26	healthcare	healthcare	NOUN
ecj-13110	261	27	by	by	ADP
ecj-13110	261	28	vulnerable	vulnerable	ADJ
ecj-13110	261	29	groups	group	NOUN
ecj-13110	261	30	.	.	PUNCT
ecj-13110	262	1	bmc	bmc	ADJ
ecj-13110	262	2	med	med	ADJ
ecj-13110	262	3	res	re	NOUN
ecj-13110	262	4	methodol	methodol	NOUN
ecj-13110	262	5	2006;6:35	2006;6:35	NOUN
ecj-13110	262	6	.	.	PUNCT
ecj-13110	263	1	13	13	NUM
ecj-13110	263	2	.	.	PUNCT
ecj-13110	263	3	skulberg	skulberg	PROPN
ecj-13110	263	4	ak	ak	PROPN
ecj-13110	263	5	,	,	PUNCT
ecj-13110	263	6	tylleskär	tylleskär	PROPN
ecj-13110	263	7	i	i	PROPN
ecj-13110	263	8	,	,	PUNCT
ecj-13110	263	9	valberg	valberg	PROPN
ecj-13110	263	10	m	m	PROPN
ecj-13110	263	11	,	,	PUNCT
ecj-13110	263	12	et	et	PROPN
ecj-13110	263	13	al	al	PROPN
ecj-13110	263	14	.	.	PROPN
ecj-13110	263	15	comparison	comparison	NOUN
ecj-13110	263	16	of	of	ADP
ecj-13110	263	17	intranasal	intranasal	NOUN
ecj-13110	263	18	and	and	CCONJ
ecj-13110	263	19	intramuscular	intramuscular	ADJ
ecj-13110	263	20	naloxone	naloxone	NOUN
ecj-13110	263	21	in	in	ADP
ecj-13110	263	22	opioid	opioid	ADJ
ecj-13110	263	23	overdoses	overdose	NOUN
ecj-13110	263	24	managed	manage	VERB
ecj-13110	263	25	by	by	ADP
ecj-13110	263	26	ambulance	ambulance	NOUN
ecj-13110	263	27	staff	staff	NOUN
ecj-13110	263	28	:	:	PUNCT
ecj-13110	263	29	a	a	DET
ecj-13110	263	30	double	double	ADJ
ecj-13110	263	31	-	-	PUNCT
ecj-13110	263	32	dummy	dummy	NOUN
ecj-13110	263	33	randomised	randomise	VERB
ecj-13110	263	34	controlled	control	VERB
ecj-13110	263	35	trial	trial	NOUN
ecj-13110	263	36	.	.	PUNCT
ecj-13110	264	1	addiction	addiction	NOUN
ecj-13110	264	2	2022;117:1658	2022;117:1658	NUM
ecj-13110	264	3	-	-	SYM
ecj-13110	264	4	67	67	NUM
ecj-13110	264	5	.	.	PUNCT
ecj-13110	264	6	14	14	NUM
ecj-13110	264	7	.	.	PUNCT
ecj-13110	265	1	dietze	dietze	PROPN
ecj-13110	265	2	p	p	NOUN
ecj-13110	265	3	,	,	PUNCT
ecj-13110	265	4	jauncey	jauncey	PROPN
ecj-13110	265	5	m	m	PROPN
ecj-13110	265	6	,	,	PUNCT
ecj-13110	265	7	salmon	salmon	PROPN
ecj-13110	265	8	a	a	X
ecj-13110	265	9	,	,	PUNCT
ecj-13110	265	10	et	et	PROPN
ecj-13110	265	11	al	al	PROPN
ecj-13110	265	12	.	.	PROPN
ecj-13110	265	13	effect	effect	NOUN
ecj-13110	265	14	of	of	ADP
ecj-13110	265	15	intranasal	intranasal	NOUN
ecj-13110	265	16	vs	vs	ADP
ecj-13110	265	17	intramuscular	intramuscular	ADJ
ecj-13110	265	18	naloxone	naloxone	NOUN
ecj-13110	265	19	on	on	ADP
ecj-13110	265	20	opioid	opioid	ADJ
ecj-13110	265	21	overdose	overdose	NOUN
ecj-13110	265	22	:	:	PUNCT
ecj-13110	265	23	a	a	DET
ecj-13110	265	24	randomized	randomized	ADJ
ecj-13110	265	25	clinical	clinical	ADJ
ecj-13110	265	26	trial	trial	NOUN
ecj-13110	265	27	.	.	PUNCT
ecj-13110	266	1	jama	jama	PROPN
ecj-13110	266	2	netw	netw	PROPN
ecj-13110	266	3	open	open	ADJ
ecj-13110	266	4	2019;2	2019;2	NUM
ecj-13110	266	5	:	:	PUNCT
ecj-13110	266	6	e1914977	e1914977	NOUN
ecj-13110	266	7	.	.	PUNCT
ecj-13110	267	1	erratum	erratum	PROPN
ecj-13110	267	2	in	in	ADP
ecj-13110	267	3	:	:	PUNCT
ecj-13110	267	4	jama	jama	PROPN
ecj-13110	267	5	netw	netw	PROPN
ecj-13110	267	6	open	open	ADJ
ecj-13110	267	7	2020;3	2020;3	PROPN
ecj-13110	267	8	:	:	PUNCT
ecj-13110	267	9	e206593	e206593	PROPN
ecj-13110	267	10	.	.	NOUN
ecj-13110	268	1	15	15	NUM
ecj-13110	268	2	.	.	PUNCT
ecj-13110	269	1	skulberg	skulberg	PROPN
ecj-13110	269	2	a	a	PROPN
ecj-13110	269	3	,	,	PUNCT
ecj-13110	269	4	åsberg	åsberg	PROPN
ecj-13110	269	5	a	a	PRON
ecj-13110	269	6	,	,	PUNCT
ecj-13110	269	7	khiabani	khiabani	PROPN
ecj-13110	269	8	hz	hz	PROPN
ecj-13110	269	9	,	,	PUNCT
ecj-13110	269	10	et	et	PROPN
ecj-13110	269	11	al	al	PROPN
ecj-13110	269	12	.	.	PUNCT
ecj-13110	270	1	pharmacokinetics	pharmacokinetic	NOUN
ecj-13110	270	2	of	of	ADP
ecj-13110	270	3	a	a	DET
ecj-13110	270	4	novel	novel	NOUN
ecj-13110	270	5	,	,	PUNCT
ecj-13110	270	6	approved	approve	VERB
ecj-13110	270	7	,	,	PUNCT
ecj-13110	270	8	1.4	1.4	NUM
ecj-13110	270	9	mg	mg	NOUN
ecj-13110	270	10	intranasal	intranasal	ADJ
ecj-13110	270	11	naloxone	naloxone	ADJ
ecj-13110	270	12	formulation	formulation	NOUN
ecj-13110	270	13	for	for	ADP
ecj-13110	270	14	reversal	reversal	NOUN
ecj-13110	270	15	of	of	ADP
ecj-13110	270	16	opioid	opioid	ADJ
ecj-13110	270	17	overdose	overdose	NOUN
ecj-13110	270	18	:	:	PUNCT
ecj-13110	270	19	a	a	DET
ecj-13110	270	20	randomized	randomized	ADJ
ecj-13110	270	21	controlled	control	VERB
ecj-13110	270	22	trial	trial	NOUN
ecj-13110	270	23	.	.	PUNCT
ecj-13110	271	1	addiction	addiction	NOUN
ecj-13110	271	2	2019;114:859	2019;114:859	NUM
ecj-13110	271	3	-	-	SYM
ecj-13110	271	4	67	67	NUM
ecj-13110	271	5	.	.	PUNCT
ecj-13110	271	6	16	16	NUM
ecj-13110	271	7	.	.	PUNCT
ecj-13110	272	1	skulberg	skulberg	PROPN
ecj-13110	272	2	a	a	PROPN
ecj-13110	272	3	,	,	PUNCT
ecj-13110	272	4	tylleskär	tylleskär	PROPN
ecj-13110	272	5	i	i	PROPN
ecj-13110	272	6	,	,	PUNCT
ecj-13110	272	7	nilsen	nilsen	PROPN
ecj-13110	272	8	t	t	PROPN
ecj-13110	272	9	,	,	PUNCT
ecj-13110	272	10	et	et	PROPN
ecj-13110	272	11	al	al	PROPN
ecj-13110	272	12	.	.	PUNCT
ecj-13110	272	13	pharmacokinetics	pharmacokinetic	NOUN
ecj-13110	272	14	and	and	CCONJ
ecj-13110	272	15	-dynamics	-dynamic	NOUN
ecj-13110	272	16	of	of	ADP
ecj-13110	272	17	intramuscular	intramuscular	ADJ
ecj-13110	272	18	and	and	CCONJ
ecj-13110	272	19	intranasal	intranasal	ADJ
ecj-13110	272	20	naloxone	naloxone	NOUN
ecj-13110	272	21	:	:	PUNCT
ecj-13110	272	22	an	an	DET
ecj-13110	272	23	explorative	explorative	ADJ
ecj-13110	272	24	study	study	NOUN
ecj-13110	272	25	in	in	ADP
ecj-13110	272	26	healthy	healthy	ADJ
ecj-13110	272	27	volunteers	volunteer	NOUN
ecj-13110	272	28	.	.	PUNCT
ecj-13110	273	1	eur	eur	PROPN
ecj-13110	273	2	j	j	PROPN
ecj-13110	273	3	clin	clin	PROPN
ecj-13110	273	4	pharmacol	pharmacol	PROPN
ecj-13110	273	5	2018	2018	NUM
ecj-13110	273	6	;	;	PUNCT
ecj-13110	273	7	74:873	74:873	NUM
ecj-13110	273	8	-	-	SYM
ecj-13110	273	9	83	83	NUM
ecj-13110	273	10	.	.	PUNCT
ecj-13110	273	11	17	17	NUM
ecj-13110	273	12	.	.	PUNCT
ecj-13110	274	1	mcdonald	mcdonald	PROPN
ecj-13110	274	2	r	r	PROPN
ecj-13110	274	3	,	,	PUNCT
ecj-13110	274	4	lorch	lorch	VERB
ecj-13110	274	5	u	u	PROPN
ecj-13110	274	6	,	,	PUNCT
ecj-13110	274	7	woodward	woodward	PROPN
ecj-13110	274	8	j	j	PROPN
ecj-13110	274	9	,	,	PUNCT
ecj-13110	274	10	et	et	PROPN
ecj-13110	274	11	al	al	PROPN
ecj-13110	274	12	.	.	PUNCT
ecj-13110	275	1	pharmacokinetics	pharmacokinetic	NOUN
ecj-13110	275	2	of	of	ADP
ecj-13110	275	3	concentrated	concentrate	VERB
ecj-13110	275	4	naloxone	naloxone	ADJ
ecj-13110	275	5	nasal	nasal	NOUN
ecj-13110	275	6	spray	spray	NOUN
ecj-13110	275	7	for	for	ADP
ecj-13110	275	8	opioid	opioid	ADJ
ecj-13110	275	9	overdose	overdose	ADJ
ecj-13110	275	10	reversal	reversal	NOUN
ecj-13110	275	11	:	:	PUNCT
ecj-13110	275	12	phase	phase	NOUN
ecj-13110	275	13	i	i	PRON
ecj-13110	275	14	healthy	healthy	ADJ
ecj-13110	275	15	volunteer	volunteer	NOUN
ecj-13110	275	16	study	study	NOUN
ecj-13110	275	17	.	.	PUNCT
ecj-13110	276	1	addiction	addiction	NOUN
ecj-13110	276	2	2018;113:484	2018;113:484	NUM
ecj-13110	276	3	-	-	SYM
ecj-13110	276	4	93	93	NUM
ecj-13110	276	5	.	.	PUNCT
ecj-13110	276	6	18	18	NUM
ecj-13110	276	7	.	.	PUNCT
ecj-13110	277	1	yousefifard	yousefifard	PROPN
ecj-13110	277	2	m	m	PROPN
ecj-13110	277	3	,	,	PUNCT
ecj-13110	277	4	vazirizadeh	vazirizadeh	NOUN
ecj-13110	277	5	-	-	PUNCT
ecj-13110	277	6	mahabadi	mahabadi	PROPN
ecj-13110	277	7	mh	mh	PROPN
ecj-13110	277	8	,	,	PUNCT
ecj-13110	277	9	neishaboori	neishaboori	PROPN
ecj-13110	277	10	am	be	AUX
ecj-13110	277	11	,	,	PUNCT
ecj-13110	277	12	et	et	PROPN
ecj-13110	277	13	al	al	PROPN
ecj-13110	277	14	.	.	PROPN
ecj-13110	277	15	intranasal	intranasal	NOUN
ecj-13110	277	16	versus	versus	ADP
ecj-13110	277	17	intramuscular	intramuscular	ADJ
ecj-13110	277	18	/	/	SYM
ecj-13110	277	19	intravenous	intravenous	ADJ
ecj-13110	277	20	naloxone	naloxone	NOUN
ecj-13110	277	21	for	for	ADP
ecj-13110	277	22	pre	pre	ADJ
ecj-13110	277	23	-	-	ADJ
ecj-13110	277	24	hospital	hospital	ADJ
ecj-13110	277	25	opioid	opioid	NOUN
ecj-13110	277	26	overdose	overdose	NOUN
ecj-13110	277	27	:	:	PUNCT
ecj-13110	277	28	a	a	DET
ecj-13110	277	29	systematic	systematic	ADJ
ecj-13110	277	30	review	review	NOUN
ecj-13110	277	31	and	and	CCONJ
ecj-13110	277	32	meta	meta	ADJ
ecj-13110	277	33	-	-	PUNCT
ecj-13110	277	34	analysis	analysis	NOUN
ecj-13110	277	35	.	.	PUNCT
ecj-13110	278	1	adv	adv	PROPN
ecj-13110	279	1	j	j	PROPN
ecj-13110	279	2	emerg	emerg	PROPN
ecj-13110	279	3	med	med	ADJ
ecj-13110	279	4	2019;4	2019;4	NOUN
ecj-13110	279	5	:	:	PUNCT
ecj-13110	279	6	e27	e27	NOUN
ecj-13110	279	7	.	.	PUNCT
ecj-13110	280	1	19	19	NUM
ecj-13110	280	2	.	.	PUNCT
ecj-13110	281	1	banerjee	banerjee	PROPN
ecj-13110	281	2	s	s	PROPN
ecj-13110	281	3	,	,	PUNCT
ecj-13110	281	4	wright	wright	PROPN
ecj-13110	281	5	md	md	PROPN
ecj-13110	281	6	.	.	PUNCT
ecj-13110	282	1	injectable	injectable	PROPN
ecj-13110	282	2	opioid	opioid	ADJ
ecj-13110	282	3	agonist	agonist	NOUN
ecj-13110	282	4	treatment	treatment	NOUN
ecj-13110	282	5	for	for	ADP
ecj-13110	282	6	patients	patient	NOUN
ecj-13110	282	7	with	with	ADP
ecj-13110	282	8	opioid	opioid	ADJ
ecj-13110	282	9	dependence	dependence	NOUN
ecj-13110	282	10	:	:	PUNCT
ecj-13110	282	11	a	a	DET
ecj-13110	282	12	review	review	NOUN
ecj-13110	282	13	of	of	ADP
ecj-13110	282	14	clinical	clinical	ADJ
ecj-13110	282	15	and	and	CCONJ
ecj-13110	282	16	cost	cost	NOUN
ecj-13110	282	17	-	-	PUNCT
ecj-13110	282	18	effectiveness	effectiveness	NOUN
ecj-13110	282	19	[	[	X
ecj-13110	282	20	internet	internet	NOUN
ecj-13110	282	21	]	]	PUNCT
ecj-13110	282	22	.	.	PUNCT
ecj-13110	283	1	ottawa	ottawa	PROPN
ecj-13110	283	2	(	(	PUNCT
ecj-13110	283	3	on	on	ADP
ecj-13110	283	4	):	):	PUNCT
ecj-13110	283	5	canadian	canadian	ADJ
ecj-13110	283	6	agency	agency	NOUN
ecj-13110	283	7	for	for	ADP
ecj-13110	283	8	drugs	drug	NOUN
ecj-13110	283	9	and	and	CCONJ
ecj-13110	283	10	technologies	technology	NOUN
ecj-13110	283	11	in	in	ADP
ecj-13110	283	12	health	health	NOUN
ecj-13110	283	13	;	;	PUNCT
ecj-13110	283	14	2020	2020	NUM
ecj-13110	283	15	.	.	X
ecj-13110	284	1	20	20	NUM
ecj-13110	284	2	.	.	X
ecj-13110	285	1	wermeling	wermele	VERB
ecj-13110	285	2	dp	dp	PROPN
ecj-13110	285	3	.	.	PUNCT
ecj-13110	285	4	review	review	NOUN
ecj-13110	285	5	of	of	ADP
ecj-13110	285	6	naloxone	naloxone	ADJ
ecj-13110	285	7	safety	safety	NOUN
ecj-13110	285	8	for	for	ADP
ecj-13110	285	9	opioid	opioid	ADJ
ecj-13110	285	10	overdose	overdose	NOUN
ecj-13110	285	11	:	:	PUNCT
ecj-13110	285	12	practical	practical	ADJ
ecj-13110	285	13	considerations	consideration	NOUN
ecj-13110	285	14	for	for	ADP
ecj-13110	285	15	new	new	ADJ
ecj-13110	285	16	technology	technology	NOUN
ecj-13110	285	17	and	and	CCONJ
ecj-13110	285	18	expanded	expand	VERB
ecj-13110	285	19	public	public	ADJ
ecj-13110	285	20	access	access	NOUN
ecj-13110	285	21	.	.	PUNCT
ecj-13110	286	1	ther	ther	VERB
ecj-13110	286	2	adv	adv	PROPN
ecj-13110	286	3	drug	drug	PROPN
ecj-13110	286	4	saf	saf	PROPN
ecj-13110	286	5	2015;6:20	2015;6:20	NOUN
ecj-13110	286	6	-	-	SYM
ecj-13110	286	7	31	31	NUM
ecj-13110	286	8	.	.	PUNCT
ecj-13110	287	1	21	21	NUM
ecj-13110	287	2	.	.	PUNCT
ecj-13110	287	3	gowing	gowing	PROPN
ecj-13110	287	4	l	l	PROPN
ecj-13110	287	5	,	,	PUNCT
ecj-13110	287	6	ali	ali	PROPN
ecj-13110	287	7	r	r	PROPN
ecj-13110	287	8	,	,	PUNCT
ecj-13110	287	9	white	white	PROPN
ecj-13110	287	10	jm	jm	PROPN
ecj-13110	287	11	.	.	PROPN
ecj-13110	288	1	opioid	opioid	PROPN
ecj-13110	288	2	antagonists	antagonist	NOUN
ecj-13110	288	3	with	with	ADP
ecj-13110	288	4	minimal	minimal	ADJ
ecj-13110	288	5	sedation	sedation	NOUN
ecj-13110	288	6	for	for	ADP
ecj-13110	288	7	opioid	opioid	ADJ
ecj-13110	288	8	withdrawal	withdrawal	NOUN
ecj-13110	288	9	.	.	PUNCT
ecj-13110	289	1	cochrane	cochrane	PROPN
ecj-13110	289	2	database	database	PROPN
ecj-13110	289	3	syst	syst	PROPN
ecj-13110	289	4	rev	rev	PROPN
ecj-13110	289	5	.	.	PUNCT
ecj-13110	290	1	2017;5	2017;5	PRON
ecj-13110	290	2	:	:	PUNCT
ecj-13110	290	3	cd002021	cd002021	NOUN
ecj-13110	290	4	.	.	PUNCT
ecj-13110	291	1	22	22	NUM
ecj-13110	291	2	.	.	X
ecj-13110	291	3	bennett	bennett	PROPN
ecj-13110	291	4	as	as	ADP
ecj-13110	291	5	,	,	PUNCT
ecj-13110	291	6	freeman	freeman	PROPN
ecj-13110	291	7	r	r	PROPN
ecj-13110	291	8	,	,	PUNCT
ecj-13110	291	9	des	des	PROPN
ecj-13110	291	10	jarlais	jarlais	PROPN
ecj-13110	291	11	dc	dc	PROPN
ecj-13110	291	12	,	,	PUNCT
ecj-13110	291	13	aronson	aronson	PROPN
ecj-13110	291	14	i	i	PROPN
ecj-13110	291	15	d.	d.	PROPN
ecj-13110	291	16	reasons	reason	VERB
ecj-13110	291	17	people	people	NOUN
ecj-13110	291	18	who	who	PRON
ecj-13110	291	19	use	use	VERB
ecj-13110	291	20	opioids	opioid	NOUN
ecj-13110	291	21	do	do	AUX
ecj-13110	291	22	not	not	PART
ecj-13110	291	23	accept	accept	VERB
ecj-13110	291	24	or	or	CCONJ
ecj-13110	291	25	carry	carry	VERB
ecj-13110	291	26	no	no	DET
ecj-13110	291	27	-	-	PUNCT
ecj-13110	291	28	cost	cost	NOUN
ecj-13110	291	29	naloxone	naloxone	NOUN
ecj-13110	291	30	:	:	PUNCT
ecj-13110	291	31	qualitative	qualitative	ADJ
ecj-13110	291	32	interview	interview	NOUN
ecj-13110	291	33	study	study	NOUN
ecj-13110	291	34	.	.	PUNCT
ecj-13110	292	1	jmir	jmir	PROPN
ecj-13110	292	2	form	form	PROPN
ecj-13110	292	3	res	re	NOUN
ecj-13110	292	4	2020;4	2020;4	NUM
ecj-13110	292	5	.	.	PUNCT
ecj-13110	293	1	23	23	NUM
ecj-13110	293	2	.	.	PUNCT
ecj-13110	294	1	lewis	lewis	PROPN
ecj-13110	294	2	cr	cr	PROPN
ecj-13110	294	3	,	,	PUNCT
ecj-13110	294	4	vo	vo	PROPN
ecj-13110	294	5	ht	ht	PROPN
ecj-13110	294	6	,	,	PUNCT
ecj-13110	294	7	fishman	fishman	PROPN
ecj-13110	294	8	m.	m.	PROPN
ecj-13110	294	9	intranasal	intranasal	NOUN
ecj-13110	294	10	naloxone	naloxone	NOUN
ecj-13110	294	11	and	and	CCONJ
ecj-13110	294	12	related	related	ADJ
ecj-13110	294	13	strategies	strategy	NOUN
ecj-13110	294	14	for	for	ADP
ecj-13110	294	15	opioid	opioid	ADJ
ecj-13110	294	16	overdose	overdose	NOUN
ecj-13110	294	17	intervention	intervention	NOUN
ecj-13110	294	18	by	by	ADP
ecj-13110	294	19	nonmedical	nonmedical	ADJ
ecj-13110	294	20	personnel	personnel	NOUN
ecj-13110	294	21	:	:	PUNCT
ecj-13110	294	22	a	a	DET
ecj-13110	294	23	review	review	NOUN
ecj-13110	294	24	.	.	PUNCT
ecj-13110	295	1	subst	subst	NOUN
ecj-13110	295	2	abuse	abuse	NOUN
ecj-13110	295	3	rehabil	rehabil	VERB
ecj-13110	295	4	2017;8:79	2017;8:79	NOUN
ecj-13110	295	5	-	-	SYM
ecj-13110	295	6	95	95	NUM
ecj-13110	295	7	.	.	PUNCT
ecj-13110	296	1	24	24	NUM
ecj-13110	296	2	.	.	PUNCT
ecj-13110	296	3	grassin	grassin	NOUN
ecj-13110	296	4	-	-	PUNCT
ecj-13110	296	5	delyle	delyle	NOUN
ecj-13110	296	6	s	s	NOUN
ecj-13110	296	7	,	,	PUNCT
ecj-13110	296	8	buenestado	buenestado	VERB
ecj-13110	296	9	a	a	DET
ecj-13110	296	10	,	,	PUNCT
ecj-13110	296	11	naline	naline	ADJ
ecj-13110	296	12	e	e	NOUN
ecj-13110	296	13	,	,	PUNCT
ecj-13110	296	14	et	et	PROPN
ecj-13110	296	15	al	al	PROPN
ecj-13110	296	16	.	.	PROPN
ecj-13110	296	17	intranasal	intranasal	ADJ
ecj-13110	296	18	drug	drug	NOUN
ecj-13110	296	19	delivery	delivery	NOUN
ecj-13110	296	20	:	:	PUNCT
ecj-13110	296	21	an	an	DET
ecj-13110	296	22	efficient	efficient	ADJ
ecj-13110	296	23	and	and	CCONJ
ecj-13110	296	24	non	non	ADJ
ecj-13110	296	25	-	-	ADJ
ecj-13110	296	26	invasive	invasive	ADJ
ecj-13110	296	27	route	route	NOUN
ecj-13110	296	28	for	for	ADP
ecj-13110	296	29	systemic	systemic	ADJ
ecj-13110	296	30	administration	administration	NOUN
ecj-13110	296	31	:	:	PUNCT
ecj-13110	296	32	focus	focus	VERB
ecj-13110	296	33	on	on	ADP
ecj-13110	296	34	opioids	opioid	NOUN
ecj-13110	296	35	.	.	PUNCT
ecj-13110	297	1	pharmacol	pharmacol	NOUN
ecj-13110	297	2	ther	ther	ADV
ecj-13110	297	3	2012;134	2012;134	NUM
ecj-13110	297	4	:	:	PUNCT
ecj-13110	297	5	366	366	NUM
ecj-13110	297	6	-	-	SYM
ecj-13110	297	7	79	79	NUM
ecj-13110	297	8	.	.	PUNCT
ecj-13110	298	1	25	25	NUM
ecj-13110	298	2	.	.	PUNCT
ecj-13110	298	3	rock	rock	PROPN
ecj-13110	298	4	p	p	PROPN
ecj-13110	298	5	,	,	PUNCT
ecj-13110	298	6	slavova	slavova	PROPN
ecj-13110	298	7	s	s	PROPN
ecj-13110	298	8	,	,	PUNCT
ecj-13110	298	9	westgate	westgate	PROPN
ecj-13110	298	10	pm	pm	PROPN
ecj-13110	298	11	,	,	PUNCT
ecj-13110	298	12	et	et	PROPN
ecj-13110	298	13	al	al	PROPN
ecj-13110	298	14	.	.	PROPN
ecj-13110	298	15	examination	examination	NOUN
ecj-13110	298	16	of	of	ADP
ecj-13110	298	17	naloxone	naloxone	ADJ
ecj-13110	298	18	dosing	dose	VERB
ecj-13110	298	19	patterns	pattern	NOUN
ecj-13110	298	20	for	for	ADP
ecj-13110	298	21	opioid	opioid	ADJ
ecj-13110	298	22	overdose	overdose	NOUN
ecj-13110	298	23	by	by	ADP
ecj-13110	298	24	emergency	emergency	NOUN
ecj-13110	298	25	medical	medical	ADJ
ecj-13110	298	26	services	service	NOUN
ecj-13110	298	27	in	in	ADP
ecj-13110	298	28	kentucky	kentucky	PROPN
ecj-13110	298	29	during	during	ADP
ecj-13110	298	30	increased	increase	VERB
ecj-13110	298	31	fentanyl	fentanyl	ADJ
ecj-13110	298	32	use	use	NOUN
ecj-13110	298	33	from	from	ADP
ecj-13110	298	34	2018	2018	NUM
ecj-13110	298	35	to	to	ADP
ecj-13110	298	36	2021	2021	NUM
ecj-13110	298	37	.	.	PUNCT
ecj-13110	299	1	drug	drug	NOUN
ecj-13110	299	2	alcohol	alcohol	NOUN
ecj-13110	299	3	depend	depend	VERB
ecj-13110	299	4	2024;255:111062	2024;255:111062	NUM
ecj-13110	299	5	.	.	PUNCT
ecj-13110	300	1	26	26	NUM
ecj-13110	300	2	.	.	PUNCT
ecj-13110	301	1	saari	saari	PROPN
ecj-13110	301	2	ti	ti	PROPN
ecj-13110	301	3	,	,	PUNCT
ecj-13110	301	4	strang	strang	PROPN
ecj-13110	301	5	j	j	PROPN
ecj-13110	301	6	,	,	PUNCT
ecj-13110	301	7	dale	dale	PROPN
ecj-13110	301	8	o.	o.	PROPN
ecj-13110	301	9	clinical	clinical	ADJ
ecj-13110	301	10	pharmacokinetics	pharmacokinetic	NOUN
ecj-13110	301	11	and	and	CCONJ
ecj-13110	301	12	pharmacodynamics	pharmacodynamic	NOUN
ecj-13110	301	13	of	of	ADP
ecj-13110	301	14	naloxone	naloxone	NOUN
ecj-13110	301	15	.	.	PUNCT
ecj-13110	302	1	clin	clin	PROPN
ecj-13110	302	2	pharmacokinet	pharmacokinet	PROPN
ecj-13110	302	3	2024;63:397422	2024;63:397422	PROPN
ecj-13110	302	4	.	.	PUNCT
ecj-13110	302	5	27	27	NUM
ecj-13110	302	6	.	.	PUNCT
ecj-13110	303	1	walsh	walsh	PROPN
ecj-13110	303	2	sl	sl	PROPN
ecj-13110	303	3	,	,	PUNCT
ecj-13110	303	4	el	el	PROPN
ecj-13110	303	5	-	-	PROPN
ecj-13110	303	6	bassel	bassel	PROPN
ecj-13110	303	7	n	n	CCONJ
ecj-13110	303	8	,	,	PUNCT
ecj-13110	303	9	jackson	jackson	PROPN
ecj-13110	303	10	rd	rd	PROPN
ecj-13110	303	11	,	,	PUNCT
ecj-13110	303	12	et	et	PROPN
ecj-13110	303	13	al	al	PROPN
ecj-13110	303	14	.	.	PUNCT
ecj-13110	304	1	the	the	DET
ecj-13110	304	2	healing	heal	VERB
ecj-13110	304	3	communities	community	NOUN
ecj-13110	304	4	study	study	NOUN
ecj-13110	304	5	:	:	PUNCT
ecj-13110	304	6	protocol	protocol	NOUN
ecj-13110	304	7	for	for	ADP
ecj-13110	304	8	a	a	DET
ecj-13110	304	9	cluster	cluster	NOUN
ecj-13110	304	10	randomized	randomize	VERB
ecj-13110	304	11	trial	trial	NOUN
ecj-13110	304	12	to	to	PART
ecj-13110	304	13	review	review	VERB
ecj-13110	304	14	[	[	X
ecj-13110	304	15	page	page	NOUN
ecj-13110	304	16	46	46	NUM
ecj-13110	304	17	]	]	PUNCT
ecj-13110	305	1	[	[	X
ecj-13110	305	2	emergency	emergency	NOUN
ecj-13110	305	3	care	care	NOUN
ecj-13110	305	4	journal	journal	NOUN
ecj-13110	305	5	2025	2025	NUM
ecj-13110	305	6	;	;	PUNCT
ecj-13110	305	7	21:13110	21:13110	NUM
ecj-13110	305	8	]	]	PUNCT
ecj-13110	305	9	reduce	reduce	VERB
ecj-13110	305	10	opioid	opioid	ADJ
ecj-13110	305	11	overdose	overdose	ADJ
ecj-13110	305	12	deaths	death	NOUN
ecj-13110	305	13	.	.	PUNCT
ecj-13110	306	1	drug	drug	NOUN
ecj-13110	306	2	alcohol	alcohol	NOUN
ecj-13110	306	3	depend	depend	VERB
ecj-13110	306	4	2020;217:108335	2020;217:108335	NUM
ecj-13110	306	5	.	.	PUNCT
ecj-13110	307	1	28	28	NUM
ecj-13110	307	2	.	.	PUNCT
ecj-13110	308	1	oesterle	oesterle	PROPN
ecj-13110	308	2	s	s	PART
ecj-13110	308	3	,	,	PUNCT
ecj-13110	308	4	kuklinski	kuklinski	VERB
ecj-13110	308	5	mr	mr	PROPN
ecj-13110	308	6	,	,	PUNCT
ecj-13110	308	7	hawkins	hawkins	PROPN
ecj-13110	308	8	jd	jd	PROPN
ecj-13110	308	9	,	,	PUNCT
ecj-13110	308	10	et	et	PROPN
ecj-13110	308	11	al	al	PROPN
ecj-13110	308	12	.	.	PUNCT
ecj-13110	309	1	long	long	ADJ
ecj-13110	309	2	-	-	PUNCT
ecj-13110	309	3	term	term	NOUN
ecj-13110	309	4	effects	effect	NOUN
ecj-13110	309	5	of	of	ADP
ecj-13110	309	6	the	the	DET
ecj-13110	309	7	communities	community	NOUN
ecj-13110	309	8	that	that	PRON
ecj-13110	309	9	care	care	VERB
ecj-13110	309	10	trial	trial	NOUN
ecj-13110	309	11	on	on	ADP
ecj-13110	309	12	substance	substance	NOUN
ecj-13110	309	13	use	use	NOUN
ecj-13110	309	14	,	,	PUNCT
ecj-13110	309	15	antisocial	antisocial	ADJ
ecj-13110	309	16	behavior	behavior	NOUN
ecj-13110	309	17	,	,	PUNCT
ecj-13110	309	18	and	and	CCONJ
ecj-13110	309	19	violence	violence	NOUN
ecj-13110	309	20	through	through	ADP
ecj-13110	309	21	age	age	NOUN
ecj-13110	309	22	21	21	NUM
ecj-13110	309	23	years	year	NOUN
ecj-13110	309	24	.	.	PUNCT
ecj-13110	310	1	am	be	AUX
ecj-13110	310	2	j	j	PROPN
ecj-13110	310	3	public	public	ADJ
ecj-13110	310	4	health	health	PROPN
ecj-13110	310	5	2018;108:659	2018;108:659	PROPN
ecj-13110	310	6	-	-	SYM
ecj-13110	310	7	65	65	NUM
ecj-13110	310	8	.	.	PUNCT
ecj-13110	311	1	29	29	NUM
ecj-13110	311	2	.	.	PUNCT
ecj-13110	312	1	irvine	irvine	PROPN
ecj-13110	312	2	ma	ma	PROPN
ecj-13110	312	3	,	,	PUNCT
ecj-13110	312	4	oller	oller	PROPN
ecj-13110	312	5	d	d	PROPN
ecj-13110	312	6	,	,	PUNCT
ecj-13110	312	7	boggis	boggis	ADJ
ecj-13110	312	8	j	j	PROPN
ecj-13110	312	9	,	,	PUNCT
ecj-13110	312	10	et	et	PROPN
ecj-13110	312	11	al	al	PROPN
ecj-13110	312	12	.	.	PUNCT
ecj-13110	312	13	estimating	estimate	VERB
ecj-13110	312	14	naloxone	naloxone	ADJ
ecj-13110	312	15	need	need	NOUN
ecj-13110	312	16	in	in	ADP
ecj-13110	312	17	the	the	DET
ecj-13110	312	18	usa	usa	PROPN
ecj-13110	312	19	across	across	ADP
ecj-13110	312	20	fentanyl	fentanyl	NOUN
ecj-13110	312	21	,	,	PUNCT
ecj-13110	312	22	heroin	heroin	NOUN
ecj-13110	312	23	,	,	PUNCT
ecj-13110	312	24	and	and	CCONJ
ecj-13110	312	25	prescription	prescription	NOUN
ecj-13110	312	26	opioid	opioid	ADJ
ecj-13110	312	27	epidemics	epidemic	NOUN
ecj-13110	312	28	:	:	PUNCT
ecj-13110	312	29	a	a	DET
ecj-13110	312	30	modelling	model	VERB
ecj-13110	312	31	study	study	NOUN
ecj-13110	312	32	.	.	PUNCT
ecj-13110	313	1	lancet	lancet	PROPN
ecj-13110	313	2	public	public	ADJ
ecj-13110	313	3	health	health	NOUN
ecj-13110	313	4	2022;7	2022;7	NOUN
ecj-13110	313	5	.	.	PUNCT
ecj-13110	314	1	30	30	NUM
ecj-13110	314	2	.	.	PUNCT
ecj-13110	315	1	rzasa	rzasa	PROPN
ecj-13110	315	2	lynn	lynn	PROPN
ecj-13110	315	3	r	r	PROPN
ecj-13110	315	4	,	,	PUNCT
ecj-13110	315	5	galinkin	galinkin	ADJ
ecj-13110	315	6	jl	jl	NOUN
ecj-13110	315	7	.	.	PUNCT
ecj-13110	316	1	naloxone	naloxone	ADJ
ecj-13110	316	2	dosage	dosage	NOUN
ecj-13110	316	3	for	for	ADP
ecj-13110	316	4	opioid	opioid	ADJ
ecj-13110	316	5	reversal	reversal	NOUN
ecj-13110	316	6	:	:	PUNCT
ecj-13110	316	7	current	current	ADJ
ecj-13110	316	8	evidence	evidence	NOUN
ecj-13110	316	9	and	and	CCONJ
ecj-13110	316	10	clinical	clinical	ADJ
ecj-13110	316	11	implications	implication	NOUN
ecj-13110	316	12	.	.	PUNCT
ecj-13110	317	1	ther	ther	VERB
ecj-13110	317	2	adv	adv	PROPN
ecj-13110	318	1	drug	drug	PROPN
ecj-13110	318	2	saf	saf	PROPN
ecj-13110	318	3	2018;9:63	2018;9:63	PROPN
ecj-13110	318	4	-	-	SYM
ecj-13110	318	5	88	88	NUM
ecj-13110	318	6	.	.	PUNCT
ecj-13110	318	7	31	31	NUM
ecj-13110	318	8	.	.	PUNCT
ecj-13110	319	1	lemen	lemen	PROPN
ecj-13110	319	2	pm	pm	PROPN
ecj-13110	319	3	,	,	PUNCT
ecj-13110	319	4	garrett	garrett	PROPN
ecj-13110	319	5	dp	dp	PROPN
ecj-13110	319	6	,	,	PUNCT
ecj-13110	319	7	thompson	thompson	PROPN
ecj-13110	319	8	e	e	PROPN
ecj-13110	319	9	,	,	PUNCT
ecj-13110	319	10	et	et	PROPN
ecj-13110	319	11	al	al	PROPN
ecj-13110	319	12	.	.	PROPN
ecj-13110	319	13	high	high	ADJ
ecj-13110	319	14	-	-	PUNCT
ecj-13110	319	15	dose	dose	NOUN
ecj-13110	319	16	naloxone	naloxone	ADJ
ecj-13110	319	17	formulations	formulation	NOUN
ecj-13110	319	18	are	be	AUX
ecj-13110	319	19	not	not	PART
ecj-13110	319	20	as	as	ADV
ecj-13110	319	21	essential	essential	ADJ
ecj-13110	319	22	as	as	SCONJ
ecj-13110	319	23	we	we	PRON
ecj-13110	319	24	thought	think	VERB
ecj-13110	319	25	.	.	PUNCT
ecj-13110	320	1	harm	harm	NOUN
ecj-13110	320	2	reduct	reduct	PROPN
ecj-13110	320	3	j	j	PROPN
ecj-13110	320	4	2024;21:93	2024;21:93	NUM
ecj-13110	320	5	.	.	PUNCT
ecj-13110	321	1	32	32	NUM
ecj-13110	321	2	.	.	PUNCT
ecj-13110	322	1	moe	moe	PROPN
ecj-13110	322	2	j	j	PROPN
ecj-13110	322	3	,	,	PUNCT
ecj-13110	322	4	godwin	godwin	PROPN
ecj-13110	322	5	j	j	PROPN
ecj-13110	322	6	,	,	PUNCT
ecj-13110	322	7	purssell	purssell	PROPN
ecj-13110	322	8	r	r	NOUN
ecj-13110	322	9	,	,	PUNCT
ecj-13110	322	10	et	et	PROPN
ecj-13110	322	11	al	al	PROPN
ecj-13110	322	12	.	.	PUNCT
ecj-13110	323	1	naloxone	naloxone	PROPN
ecj-13110	323	2	dosing	dose	VERB
ecj-13110	323	3	in	in	ADP
ecj-13110	323	4	the	the	DET
ecj-13110	323	5	era	era	NOUN
ecj-13110	323	6	of	of	ADP
ecj-13110	323	7	ultra	ultra	ADJ
ecj-13110	323	8	-	-	ADJ
ecj-13110	323	9	potent	potent	ADJ
ecj-13110	323	10	opioid	opioid	NOUN
ecj-13110	323	11	overdoses	overdose	NOUN
ecj-13110	323	12	:	:	PUNCT
ecj-13110	323	13	a	a	DET
ecj-13110	323	14	systematic	systematic	ADJ
ecj-13110	323	15	review	review	NOUN
ecj-13110	323	16	.	.	PUNCT
ecj-13110	324	1	cjem	cjem	PROPN
ecj-13110	324	2	2020;22:178	2020;22:178	NUM
ecj-13110	324	3	-	-	SYM
ecj-13110	324	4	86	86	NUM
ecj-13110	324	5	.	.	PUNCT
ecj-13110	325	1	33	33	NUM
ecj-13110	325	2	.	.	PUNCT
ecj-13110	326	1	weaver	weaver	NOUN
ecj-13110	326	2	l	l	PROPN
ecj-13110	326	3	,	,	PUNCT
ecj-13110	326	4	palombi	palombi	PROPN
ecj-13110	326	5	l	l	PROPN
ecj-13110	326	6	,	,	PUNCT
ecj-13110	326	7	bastianelli	bastianelli	PROPN
ecj-13110	326	8	kms	kms	PROPN
ecj-13110	326	9	.	.	PUNCT
ecj-13110	327	1	naloxone	naloxone	ADJ
ecj-13110	327	2	administration	administration	NOUN
ecj-13110	327	3	for	for	ADP
ecj-13110	327	4	opioid	opioid	ADJ
ecj-13110	327	5	overdose	overdose	ADJ
ecj-13110	327	6	reversal	reversal	NOUN
ecj-13110	327	7	in	in	ADP
ecj-13110	327	8	the	the	DET
ecj-13110	327	9	prehospital	prehospital	NOUN
ecj-13110	327	10	setting	setting	NOUN
ecj-13110	327	11	:	:	PUNCT
ecj-13110	327	12	implications	implication	NOUN
ecj-13110	327	13	for	for	ADP
ecj-13110	327	14	pharmacists	pharmacist	NOUN
ecj-13110	327	15	.	.	PUNCT
ecj-13110	328	1	j	j	PROPN
ecj-13110	328	2	pharm	pharm	PROPN
ecj-13110	328	3	pract	pract	PROPN
ecj-13110	328	4	2018;31:91	2018;31:91	NUM
ecj-13110	328	5	-	-	SYM
ecj-13110	328	6	8	8	NUM
ecj-13110	328	7	.	.	PUNCT
ecj-13110	328	8	34	34	NUM
ecj-13110	328	9	.	.	PUNCT
ecj-13110	328	10	d'orsogna	d'orsogna	PROPN
ecj-13110	329	1	mr	mr	PROPN
ecj-13110	329	2	,	,	PUNCT
ecj-13110	329	3	böttcher	böttcher	PROPN
ecj-13110	329	4	l	l	PROPN
ecj-13110	329	5	,	,	PUNCT
ecj-13110	329	6	chou	chou	PROPN
ecj-13110	329	7	t.	t.	PROPN
ecj-13110	329	8	fentanyl	fentanyl	NOUN
ecj-13110	329	9	-	-	PUNCT
ecj-13110	329	10	driven	drive	VERB
ecj-13110	329	11	acceleration	acceleration	NOUN
ecj-13110	329	12	of	of	ADP
ecj-13110	329	13	racial	racial	ADJ
ecj-13110	329	14	,	,	PUNCT
ecj-13110	329	15	gender	gender	NOUN
ecj-13110	329	16	and	and	CCONJ
ecj-13110	329	17	geographical	geographical	ADJ
ecj-13110	329	18	disparities	disparity	NOUN
ecj-13110	329	19	in	in	ADP
ecj-13110	329	20	drug	drug	NOUN
ecj-13110	329	21	overdose	overdose	NOUN
ecj-13110	329	22	deaths	death	NOUN
ecj-13110	329	23	in	in	ADP
ecj-13110	329	24	the	the	DET
ecj-13110	329	25	united	united	PROPN
ecj-13110	329	26	states	states	PROPN
ecj-13110	329	27	.	.	PUNCT
ecj-13110	330	1	plos	plos	PROPN
ecj-13110	330	2	glob	glob	PROPN
ecj-13110	330	3	public	public	ADJ
ecj-13110	330	4	health	health	NOUN
ecj-13110	330	5	2023;3	2023;3	NOUN
ecj-13110	330	6	:	:	PUNCT
ecj-13110	330	7	e0000769	e0000769	NOUN
ecj-13110	330	8	.	.	PUNCT
ecj-13110	331	1	35	35	NUM
ecj-13110	331	2	.	.	PUNCT
ecj-13110	332	1	prekupec	prekupec	PROPN
ecj-13110	332	2	mp	mp	PROPN
ecj-13110	332	3	,	,	PUNCT
ecj-13110	332	4	mansky	mansky	PROPN
ecj-13110	332	5	pa	pa	PROPN
ecj-13110	332	6	,	,	PUNCT
ecj-13110	332	7	baumann	baumann	PROPN
ecj-13110	332	8	mh	mh	PROPN
ecj-13110	332	9	.	.	PUNCT
ecj-13110	332	10	misuse	misuse	NOUN
ecj-13110	332	11	of	of	ADP
ecj-13110	332	12	novel	novel	ADJ
ecj-13110	332	13	synthetic	synthetic	ADJ
ecj-13110	332	14	opioids	opioid	NOUN
ecj-13110	332	15	:	:	PUNCT
ecj-13110	332	16	a	a	DET
ecj-13110	332	17	deadly	deadly	ADJ
ecj-13110	332	18	new	new	ADJ
ecj-13110	332	19	trend	trend	NOUN
ecj-13110	332	20	.	.	PUNCT
ecj-13110	333	1	j	j	PROPN
ecj-13110	333	2	addict	addict	NOUN
ecj-13110	333	3	med	me	VERB
ecj-13110	333	4	2017;11:256	2017;11:256	PROPN
ecj-13110	333	5	-	-	SYM
ecj-13110	333	6	65	65	NUM
ecj-13110	333	7	.	.	PUNCT
ecj-13110	334	1	review	review	NOUN
ecj-13110	335	1	[	[	X
ecj-13110	335	2	emergency	emergency	NOUN
ecj-13110	335	3	care	care	NOUN
ecj-13110	335	4	journal	journal	NOUN
ecj-13110	335	5	2025	2025	NUM
ecj-13110	335	6	;	;	PUNCT
ecj-13110	335	7	21:13110	21:13110	NUM
ecj-13110	335	8	]	]	X
ecj-13110	336	1	[	[	X
ecj-13110	336	2	page	page	NOUN
ecj-13110	336	3	47	47	NUM
ecj-13110	336	4	]	]	PUNCT
ecj-13110	336	5	online	online	PROPN
ecj-13110	336	6	supplementary	supplementary	ADJ
ecj-13110	336	7	materials	material	NOUN
ecj-13110	336	8	table	table	NOUN
ecj-13110	336	9	1	1	NUM
ecj-13110	336	10	.	.	PUNCT
ecj-13110	336	11	summary	summary	NOUN
ecj-13110	336	12	of	of	ADP
ecj-13110	336	13	the	the	DET
ecj-13110	336	14	study	study	NOUN
ecj-13110	336	15	characteristics	characteristic	NOUN
ecj-13110	336	16	.	.	PUNCT