id	sid	tid	token	lemma	pos
ecj-1449	1	1	hrev_master	hrev_master	NOUN
ecj-1449	2	1	[	[	X
ecj-1449	2	2	page	page	NOUN
ecj-1449	2	3	24	24	NUM
ecj-1449	2	4	]	]	PUNCT
ecj-1449	3	1	[	[	X
ecj-1449	3	2	emergency	emergency	NOUN
ecj-1449	3	3	care	care	NOUN
ecj-1449	3	4	journal	journal	NOUN
ecj-1449	3	5	2013	2013	NUM
ecj-1449	3	6	;	;	PUNCT
ecj-1449	3	7	9	9	NUM
ecj-1449	3	8	:	:	SYM
ecj-1449	3	9	e9	e9	NUM
ecj-1449	3	10	]	]	PUNCT
ecj-1449	3	11	hyperlactatemia	hyperlactatemia	ADV
ecj-1449	3	12	and	and	CCONJ
ecj-1449	3	13	hypotension	hypotension	NOUN
ecj-1449	3	14	:	:	PUNCT
ecj-1449	3	15	looking	look	VERB
ecj-1449	3	16	at	at	ADP
ecj-1449	3	17	septic	septic	ADJ
ecj-1449	3	18	shock	shock	NOUN
ecj-1449	3	19	from	from	ADP
ecj-1449	3	20	different	different	ADJ
ecj-1449	3	21	perspectives	perspective	NOUN
ecj-1449	3	22	daniele	daniele	PROPN
ecj-1449	3	23	coen	coen	PROPN
ecj-1449	3	24	emergency	emergency	PROPN
ecj-1449	3	25	department	department	PROPN
ecj-1449	3	26	,	,	PUNCT
ecj-1449	3	27	niguarda	niguarda	PROPN
ecj-1449	3	28	ca	can	AUX
ecj-1449	3	29	’	'	PUNCT
ecj-1449	3	30	granda	granda	PROPN
ecj-1449	3	31	hospital	hospital	PROPN
ecj-1449	3	32	,	,	PUNCT
ecj-1449	3	33	milan	milan	PROPN
ecj-1449	3	34	,	,	PUNCT
ecj-1449	3	35	italy	italy	PROPN
ecj-1449	3	36	abstract	abstract	ADV
ecj-1449	3	37	the	the	DET
ecj-1449	3	38	last	last	ADJ
ecj-1449	3	39	decade	decade	NOUN
ecj-1449	3	40	has	have	AUX
ecj-1449	3	41	witnessed	witness	VERB
ecj-1449	3	42	significant	significant	ADJ
ecj-1449	3	43	improvements	improvement	NOUN
ecj-1449	3	44	in	in	ADP
ecj-1449	3	45	the	the	DET
ecj-1449	3	46	treatment	treatment	NOUN
ecj-1449	3	47	of	of	ADP
ecj-1449	3	48	patients	patient	NOUN
ecj-1449	3	49	with	with	ADP
ecj-1449	3	50	severe	severe	ADJ
ecj-1449	3	51	sepsis	sepsis	NOUN
ecj-1449	3	52	and	and	CCONJ
ecj-1449	3	53	septic	septic	ADJ
ecj-1449	3	54	shock	shock	NOUN
ecj-1449	3	55	,	,	PUNCT
ecj-1449	3	56	and	and	CCONJ
ecj-1449	3	57	a	a	DET
ecj-1449	3	58	reduction	reduction	NOUN
ecj-1449	3	59	in	in	ADP
ecj-1449	3	60	mortality	mortality	NOUN
ecj-1449	3	61	from	from	ADP
ecj-1449	3	62	septic	septic	ADJ
ecj-1449	3	63	syndromes	syndrome	NOUN
ecj-1449	3	64	has	have	AUX
ecj-1449	3	65	been	be	AUX
ecj-1449	3	66	described	describe	VERB
ecj-1449	3	67	by	by	ADP
ecj-1449	3	68	several	several	ADJ
ecj-1449	3	69	epidemiological	epidemiological	ADJ
ecj-1449	3	70	studies	study	NOUN
ecj-1449	3	71	.	.	PUNCT
ecj-1449	4	1	nevertheless	nevertheless	ADV
ecj-1449	4	2	,	,	PUNCT
ecj-1449	4	3	different	different	ADJ
ecj-1449	4	4	inclusion	inclusion	NOUN
ecj-1449	4	5	criteria	criterion	NOUN
ecj-1449	4	6	make	make	VERB
ecj-1449	4	7	it	it	PRON
ecj-1449	4	8	difficult	difficult	ADJ
ecj-1449	4	9	to	to	PART
ecj-1449	4	10	interpret	interpret	VERB
ecj-1449	4	11	and	and	CCONJ
ecj-1449	4	12	compare	compare	VERB
ecj-1449	4	13	the	the	DET
ecj-1449	4	14	data	datum	NOUN
ecj-1449	4	15	of	of	ADP
ecj-1449	4	16	the	the	DET
ecj-1449	4	17	literature	literature	NOUN
ecj-1449	4	18	.	.	PUNCT
ecj-1449	5	1	introduction	introduction	NOUN
ecj-1449	5	2	among	among	ADP
ecj-1449	5	3	the	the	DET
ecj-1449	5	4	most	most	ADV
ecj-1449	5	5	relevant	relevant	ADJ
ecj-1449	5	6	breakthroughs	breakthrough	NOUN
ecj-1449	5	7	in	in	ADP
ecj-1449	5	8	septic	septic	ADJ
ecj-1449	5	9	syndromes	syndrome	NOUN
ecj-1449	5	10	research	research	NOUN
ecj-1449	5	11	,	,	PUNCT
ecj-1449	5	12	many	many	ADJ
ecj-1449	5	13	would	would	AUX
ecj-1449	5	14	consider	consider	VERB
ecj-1449	5	15	early	early	ADJ
ecj-1449	5	16	goal	goal	NOUN
ecj-1449	5	17	directed	direct	VERB
ecj-1449	5	18	therapy	therapy	NOUN
ecj-1449	5	19	(	(	PUNCT
ecj-1449	5	20	egdt	egdt	ADJ
ecj-1449	5	21	)	)	PUNCT
ecj-1449	5	22	.	.	PUNCT
ecj-1449	6	1	under	under	ADP
ecj-1449	6	2	this	this	DET
ecj-1449	6	3	name	name	NOUN
ecj-1449	6	4	goes	go	VERB
ecj-1449	6	5	a	a	DET
ecj-1449	6	6	bundle	bundle	NOUN
ecj-1449	6	7	of	of	ADP
ecj-1449	6	8	interventions	intervention	NOUN
ecj-1449	6	9	that	that	PRON
ecj-1449	6	10	,	,	PUNCT
ecj-1449	6	11	when	when	SCONJ
ecj-1449	6	12	applied	apply	VERB
ecj-1449	6	13	within	within	ADP
ecj-1449	6	14	6	6	NUM
ecj-1449	6	15	h	h	NOUN
ecj-1449	6	16	from	from	ADP
ecj-1449	6	17	patients	patient	NOUN
ecj-1449	6	18	’	'	PUNCT
ecj-1449	6	19	arrival	arrival	NOUN
ecj-1449	6	20	to	to	ADP
ecj-1449	6	21	the	the	DET
ecj-1449	6	22	emergency	emergency	NOUN
ecj-1449	6	23	department	department	NOUN
ecj-1449	6	24	(	(	PUNCT
ecj-1449	6	25	ed	ed	NOUN
ecj-1449	6	26	)	)	PUNCT
ecj-1449	6	27	,	,	PUNCT
ecj-1449	6	28	has	have	AUX
ecj-1449	6	29	shown	show	VERB
ecj-1449	6	30	to	to	PART
ecj-1449	6	31	decrease	decrease	VERB
ecj-1449	6	32	absolute	absolute	ADJ
ecj-1449	6	33	in	in	ADP
ecj-1449	6	34	-	-	PUNCT
ecj-1449	6	35	hospital	hospital	NOUN
ecj-1449	6	36	mortality	mortality	NOUN
ecj-1449	6	37	by	by	ADP
ecj-1449	6	38	15%.1	15%.1	NUM
ecj-1449	6	39	although	although	SCONJ
ecj-1449	6	40	the	the	DET
ecj-1449	6	41	efficacy	efficacy	NOUN
ecj-1449	6	42	of	of	ADP
ecj-1449	6	43	egdt	egdt	PROPN
ecj-1449	6	44	has	have	AUX
ecj-1449	6	45	been	be	AUX
ecj-1449	6	46	proven	prove	VERB
ecj-1449	6	47	by	by	ADP
ecj-1449	6	48	a	a	DET
ecj-1449	6	49	single	single	ADJ
ecj-1449	6	50	randomized	randomized	ADJ
ecj-1449	6	51	clinical	clinical	ADJ
ecj-1449	6	52	trial	trial	NOUN
ecj-1449	6	53	,	,	PUNCT
ecj-1449	6	54	its	its	PRON
ecj-1449	6	55	results	result	NOUN
ecj-1449	6	56	have	have	AUX
ecj-1449	6	57	been	be	AUX
ecj-1449	6	58	supported	support	VERB
ecj-1449	6	59	by	by	ADP
ecj-1449	6	60	many	many	ADJ
ecj-1449	6	61	historically	historically	ADV
ecj-1449	6	62	-	-	PUNCT
ecj-1449	6	63	controlled	control	VERB
ecj-1449	6	64	studies2	studies2	NOUN
ecj-1449	6	65	-	-	SYM
ecj-1449	6	66	5	5	NUM
ecj-1449	6	67	that	that	DET
ecj-1449	6	68	document	document	NOUN
ecj-1449	6	69	similar	similar	ADJ
ecj-1449	6	70	improvements	improvement	NOUN
ecj-1449	6	71	in	in	ADP
ecj-1449	6	72	mortality	mortality	NOUN
ecj-1449	6	73	after	after	SCONJ
ecj-1449	6	74	a	a	DET
ecj-1449	6	75	switch	switch	NOUN
ecj-1449	6	76	from	from	ADP
ecj-1449	6	77	previous	previous	ADJ
ecj-1449	6	78	practices	practice	NOUN
ecj-1449	6	79	to	to	PART
ecj-1449	6	80	egdt	egdt	VERB
ecj-1449	6	81	.	.	PUNCT
ecj-1449	7	1	early	early	ADJ
ecj-1449	7	2	goal	goal	NOUN
ecj-1449	7	3	directed	direct	VERB
ecj-1449	7	4	therapy	therapy	NOUN
ecj-1449	7	5	aims	aim	VERB
ecj-1449	7	6	at	at	ADP
ecj-1449	7	7	restoring	restore	VERB
ecj-1449	7	8	tissue	tissue	NOUN
ecj-1449	7	9	perfusion	perfusion	NOUN
ecj-1449	7	10	in	in	ADP
ecj-1449	7	11	the	the	DET
ecj-1449	7	12	shortest	short	ADJ
ecj-1449	7	13	time	time	NOUN
ecj-1449	7	14	possible	possible	ADJ
ecj-1449	7	15	so	so	SCONJ
ecj-1449	7	16	that	that	SCONJ
ecj-1449	7	17	adequate	adequate	ADJ
ecj-1449	7	18	oxygen	oxygen	NOUN
ecj-1449	7	19	delivery	delivery	NOUN
ecj-1449	7	20	to	to	ADP
ecj-1449	7	21	essential	essential	ADJ
ecj-1449	7	22	organs	organ	NOUN
ecj-1449	7	23	may	may	AUX
ecj-1449	7	24	be	be	AUX
ecj-1449	7	25	maintained	maintain	VERB
ecj-1449	7	26	,	,	PUNCT
ecj-1449	7	27	irreversible	irreversible	ADJ
ecj-1449	7	28	mitochondrial	mitochondrial	ADJ
ecj-1449	7	29	energy	energy	NOUN
ecj-1449	7	30	failure	failure	NOUN
ecj-1449	7	31	may	may	AUX
ecj-1449	7	32	be	be	AUX
ecj-1449	7	33	averted	avert	VERB
ecj-1449	7	34	and	and	CCONJ
ecj-1449	7	35	the	the	DET
ecj-1449	7	36	development	development	NOUN
ecj-1449	7	37	of	of	ADP
ecj-1449	7	38	multi	multi	ADJ
ecj-1449	7	39	-	-	ADJ
ecj-1449	7	40	organ	organ	ADJ
ecj-1449	7	41	failure	failure	NOUN
ecj-1449	7	42	(	(	PUNCT
ecj-1449	7	43	mof	mof	X
ecj-1449	7	44	)	)	PUNCT
ecj-1449	7	45	prevented	prevent	VERB
ecj-1449	7	46	.	.	PUNCT
ecj-1449	8	1	in	in	ADP
ecj-1449	8	2	practice	practice	NOUN
ecj-1449	8	3	,	,	PUNCT
ecj-1449	8	4	the	the	DET
ecj-1449	8	5	reference	reference	NOUN
ecj-1449	8	6	study	study	NOUN
ecj-1449	8	7	by	by	ADP
ecj-1449	8	8	rivers	river	NOUN
ecj-1449	9	1	et	et	PROPN
ecj-1449	9	2	al.1	al.1	PROPN
ecj-1449	9	3	reached	reach	VERB
ecj-1449	9	4	these	these	DET
ecj-1449	9	5	results	result	NOUN
ecj-1449	9	6	administering	administer	VERB
ecj-1449	9	7	the	the	DET
ecj-1449	9	8	treatment	treatment	NOUN
ecj-1449	9	9	group	group	NOUN
ecj-1449	9	10	a	a	DET
ecj-1449	9	11	higher	high	ADJ
ecj-1449	9	12	volume	volume	NOUN
ecj-1449	9	13	of	of	ADP
ecj-1449	9	14	fluids	fluid	NOUN
ecj-1449	9	15	and	and	CCONJ
ecj-1449	9	16	a	a	DET
ecj-1449	9	17	much	much	ADV
ecj-1449	9	18	higher	high	ADJ
ecj-1449	9	19	rate	rate	NOUN
ecj-1449	9	20	of	of	ADP
ecj-1449	9	21	red	red	ADJ
ecj-1449	9	22	blood	blood	NOUN
ecj-1449	9	23	cells	cell	NOUN
ecj-1449	9	24	(	(	PUNCT
ecj-1449	9	25	rbc	rbc	PROPN
ecj-1449	9	26	)	)	PUNCT
ecj-1449	9	27	transfusions	transfusion	NOUN
ecj-1449	9	28	than	than	ADP
ecj-1449	9	29	those	those	PRON
ecj-1449	9	30	delivered	deliver	VERB
ecj-1449	9	31	to	to	ADP
ecj-1449	9	32	the	the	DET
ecj-1449	9	33	control	control	NOUN
ecj-1449	9	34	group	group	NOUN
ecj-1449	9	35	.	.	PUNCT
ecj-1449	10	1	after	after	ADP
ecj-1449	10	2	an	an	DET
ecj-1449	10	3	initial	initial	ADJ
ecj-1449	10	4	fluid	fluid	ADJ
ecj-1449	10	5	challenge	challenge	NOUN
ecj-1449	10	6	,	,	PUNCT
ecj-1449	10	7	further	further	ADJ
ecj-1449	10	8	fluid	fluid	ADJ
ecj-1449	10	9	administration	administration	NOUN
ecj-1449	10	10	and	and	CCONJ
ecj-1449	10	11	the	the	DET
ecj-1449	10	12	use	use	NOUN
ecj-1449	10	13	of	of	ADP
ecj-1449	10	14	vasoactive	vasoactive	ADJ
ecj-1449	10	15	drugs	drug	NOUN
ecj-1449	10	16	,	,	PUNCT
ecj-1449	10	17	inotropes	inotrope	NOUN
ecj-1449	10	18	and	and	CCONJ
ecj-1449	10	19	rbc	rbc	PROPN
ecj-1449	10	20	transfusion	transfusion	NOUN
ecj-1449	10	21	was	be	AUX
ecj-1449	10	22	guided	guide	VERB
ecj-1449	10	23	by	by	ADP
ecj-1449	10	24	predefined	predefine	VERB
ecj-1449	10	25	goals	goal	NOUN
ecj-1449	10	26	expressed	express	VERB
ecj-1449	10	27	as	as	ADP
ecj-1449	10	28	values	value	NOUN
ecj-1449	10	29	of	of	ADP
ecj-1449	10	30	central	central	ADJ
ecj-1449	10	31	venous	venous	ADJ
ecj-1449	10	32	pressure	pressure	NOUN
ecj-1449	10	33	(	(	PUNCT
ecj-1449	10	34	cvp	cvp	NOUN
ecj-1449	10	35	)	)	PUNCT
ecj-1449	10	36	,	,	PUNCT
ecj-1449	10	37	mean	mean	VERB
ecj-1449	10	38	arterial	arterial	ADJ
ecj-1449	10	39	pressure	pressure	NOUN
ecj-1449	10	40	(	(	PUNCT
ecj-1449	10	41	map	map	NOUN
ecj-1449	10	42	)	)	PUNCT
ecj-1449	10	43	and	and	CCONJ
ecj-1449	10	44	central	central	ADJ
ecj-1449	10	45	venous	venous	ADJ
ecj-1449	10	46	oxygen	oxygen	NOUN
ecj-1449	10	47	saturation	saturation	NOUN
ecj-1449	10	48	(	(	PUNCT
ecj-1449	10	49	scvo2	scvo2	NOUN
ecj-1449	10	50	)	)	PUNCT
ecj-1449	10	51	.	.	PUNCT
ecj-1449	11	1	this	this	DET
ecj-1449	11	2	study	study	NOUN
ecj-1449	11	3	has	have	AUX
ecj-1449	11	4	been	be	AUX
ecj-1449	11	5	criticized	criticize	VERB
ecj-1449	11	6	under	under	ADP
ecj-1449	11	7	many	many	ADJ
ecj-1449	11	8	aspects	aspect	NOUN
ecj-1449	11	9	,	,	PUNCT
ecj-1449	11	10	for	for	ADP
ecj-1449	11	11	instance	instance	NOUN
ecj-1449	11	12	the	the	DET
ecj-1449	11	13	characteristics	characteristic	NOUN
ecj-1449	11	14	of	of	ADP
ecj-1449	11	15	the	the	DET
ecj-1449	11	16	enrolled	enrol	VERB
ecj-1449	11	17	population	population	NOUN
ecj-1449	11	18	,	,	PUNCT
ecj-1449	11	19	the	the	DET
ecj-1449	11	20	use	use	NOUN
ecj-1449	11	21	of	of	ADP
ecj-1449	11	22	cvp	cvp	NOUN
ecj-1449	11	23	as	as	ADP
ecj-1449	11	24	an	an	DET
ecj-1449	11	25	indicator	indicator	NOUN
ecj-1449	11	26	for	for	ADP
ecj-1449	11	27	fluid	fluid	ADJ
ecj-1449	11	28	responsiveness	responsiveness	NOUN
ecj-1449	11	29	,	,	PUNCT
ecj-1449	11	30	the	the	DET
ecj-1449	11	31	liberal	liberal	ADJ
ecj-1449	11	32	use	use	NOUN
ecj-1449	11	33	of	of	ADP
ecj-1449	11	34	transfusions.6,7	transfusions.6,7	NOUN
ecj-1449	11	35	apart	apart	ADV
ecj-1449	11	36	from	from	ADP
ecj-1449	11	37	controversies	controversy	NOUN
ecj-1449	11	38	about	about	ADP
ecj-1449	11	39	the	the	DET
ecj-1449	11	40	specific	specific	ADJ
ecj-1449	11	41	components	component	NOUN
ecj-1449	11	42	of	of	ADP
ecj-1449	11	43	egdt	egdt	ADJ
ecj-1449	11	44	,	,	PUNCT
ecj-1449	11	45	it	it	PRON
ecj-1449	11	46	must	must	AUX
ecj-1449	11	47	be	be	AUX
ecj-1449	11	48	recognized	recognize	VERB
ecj-1449	11	49	that	that	SCONJ
ecj-1449	11	50	egdt	egdt	ADJ
ecj-1449	11	51	is	be	AUX
ecj-1449	11	52	a	a	DET
ecj-1449	11	53	bundle	bundle	NOUN
ecj-1449	11	54	of	of	ADP
ecj-1449	11	55	interventions	intervention	NOUN
ecj-1449	11	56	and	and	CCONJ
ecj-1449	11	57	that	that	SCONJ
ecj-1449	11	58	it	it	PRON
ecj-1449	11	59	is	be	AUX
ecj-1449	11	60	not	not	PART
ecj-1449	11	61	yet	yet	ADV
ecj-1449	11	62	known	know	VERB
ecj-1449	11	63	which	which	PRON
ecj-1449	11	64	of	of	ADP
ecj-1449	11	65	these	these	PRON
ecj-1449	11	66	are	be	AUX
ecj-1449	11	67	essential	essential	ADJ
ecj-1449	11	68	to	to	ADP
ecj-1449	11	69	its	its	PRON
ecj-1449	11	70	efficacy	efficacy	NOUN
ecj-1449	11	71	,	,	PUNCT
ecj-1449	11	72	which	which	PRON
ecj-1449	11	73	could	could	AUX
ecj-1449	11	74	be	be	AUX
ecj-1449	11	75	avoided	avoid	VERB
ecj-1449	11	76	or	or	CCONJ
ecj-1449	11	77	substituted	substitute	VERB
ecj-1449	11	78	,	,	PUNCT
ecj-1449	11	79	which	which	PRON
ecj-1449	11	80	might	might	AUX
ecj-1449	11	81	even	even	ADV
ecj-1449	11	82	prove	prove	VERB
ecj-1449	11	83	detrimental	detrimental	ADJ
ecj-1449	11	84	.	.	PUNCT
ecj-1449	12	1	in	in	ADP
ecj-1449	12	2	order	order	NOUN
ecj-1449	12	3	to	to	PART
ecj-1449	12	4	answer	answer	VERB
ecj-1449	12	5	the	the	DET
ecj-1449	12	6	many	many	ADJ
ecj-1449	12	7	questions	question	NOUN
ecj-1449	12	8	that	that	PRON
ecj-1449	12	9	are	be	AUX
ecj-1449	12	10	still	still	ADV
ecj-1449	12	11	open	open	ADJ
ecj-1449	12	12	,	,	PUNCT
ecj-1449	12	13	it	it	PRON
ecj-1449	12	14	is	be	AUX
ecj-1449	12	15	foreseeable	foreseeable	ADJ
ecj-1449	12	16	that	that	SCONJ
ecj-1449	12	17	many	many	ADJ
ecj-1449	12	18	studies	study	NOUN
ecj-1449	12	19	will	will	AUX
ecj-1449	12	20	be	be	AUX
ecj-1449	12	21	produced	produce	VERB
ecj-1449	12	22	in	in	ADP
ecj-1449	12	23	the	the	DET
ecj-1449	12	24	near	near	ADJ
ecj-1449	12	25	future	future	NOUN
ecj-1449	12	26	.	.	PUNCT
ecj-1449	13	1	to	to	PART
ecj-1449	13	2	produce	produce	VERB
ecj-1449	13	3	results	result	NOUN
ecj-1449	13	4	capable	capable	ADJ
ecj-1449	13	5	of	of	ADP
ecj-1449	13	6	changing	change	VERB
ecj-1449	13	7	clinical	clinical	ADJ
ecj-1449	13	8	practice	practice	NOUN
ecj-1449	13	9	,	,	PUNCT
ecj-1449	13	10	it	it	PRON
ecj-1449	13	11	is	be	AUX
ecj-1449	13	12	fundamental	fundamental	ADJ
ecj-1449	13	13	that	that	SCONJ
ecj-1449	13	14	these	these	DET
ecj-1449	13	15	studies	study	NOUN
ecj-1449	13	16	share	share	VERB
ecj-1449	13	17	common	common	ADJ
ecj-1449	13	18	definitions	definition	NOUN
ecj-1449	13	19	,	,	PUNCT
ecj-1449	13	20	select	select	VERB
ecj-1449	13	21	their	their	PRON
ecj-1449	13	22	populations	population	NOUN
ecj-1449	13	23	adequately	adequately	ADV
ecj-1449	13	24	and	and	CCONJ
ecj-1449	13	25	express	express	VERB
ecj-1449	13	26	their	their	PRON
ecj-1449	13	27	results	result	NOUN
ecj-1449	13	28	in	in	ADP
ecj-1449	13	29	such	such	DET
ecj-1449	13	30	a	a	DET
ecj-1449	13	31	way	way	NOUN
ecj-1449	13	32	that	that	SCONJ
ecj-1449	13	33	comparisons	comparison	NOUN
ecj-1449	13	34	can	can	AUX
ecj-1449	13	35	be	be	AUX
ecj-1449	13	36	easier	easy	ADJ
ecj-1449	13	37	.	.	PUNCT
ecj-1449	14	1	in	in	ADP
ecj-1449	14	2	this	this	DET
ecj-1449	14	3	paper	paper	NOUN
ecj-1449	14	4	we	we	PRON
ecj-1449	14	5	shall	shall	AUX
ecj-1449	14	6	discuss	discuss	VERB
ecj-1449	14	7	one	one	NUM
ecj-1449	14	8	of	of	ADP
ecj-1449	14	9	the	the	DET
ecj-1449	14	10	aspects	aspect	NOUN
ecj-1449	14	11	that	that	PRON
ecj-1449	14	12	make	make	VERB
ecj-1449	14	13	it	it	PRON
ecj-1449	14	14	difficult	difficult	ADJ
ecj-1449	14	15	to	to	PART
ecj-1449	14	16	read	read	VERB
ecj-1449	14	17	and	and	CCONJ
ecj-1449	14	18	compare	compare	VERB
ecj-1449	14	19	clinical	clinical	ADJ
ecj-1449	14	20	literature	literature	NOUN
ecj-1449	14	21	on	on	ADP
ecj-1449	14	22	severe	severe	ADJ
ecj-1449	14	23	sepsis	sepsis	NOUN
ecj-1449	14	24	and	and	CCONJ
ecj-1449	14	25	septic	septic	ADJ
ecj-1449	14	26	shock	shock	NOUN
ecj-1449	14	27	,	,	PUNCT
ecj-1449	14	28	namely	namely	ADV
ecj-1449	14	29	the	the	DET
ecj-1449	14	30	criteria	criterion	NOUN
ecj-1449	14	31	utilized	utilize	VERB
ecj-1449	14	32	to	to	PART
ecj-1449	14	33	define	define	VERB
ecj-1449	14	34	septic	septic	ADJ
ecj-1449	14	35	shock	shock	NOUN
ecj-1449	14	36	.	.	PUNCT
ecj-1449	15	1	opinion	opinion	NOUN
ecj-1449	15	2	report	report	NOUN
ecj-1449	15	3	during	during	ADP
ecj-1449	15	4	the	the	DET
ecj-1449	15	5	conference	conference	NOUN
ecj-1449	15	6	on	on	ADP
ecj-1449	15	7	international	international	ADJ
ecj-1449	15	8	sepsis	sepsis	NOUN
ecj-1449	15	9	definitions	definition	NOUN
ecj-1449	15	10	organized	organize	VERB
ecj-1449	15	11	in	in	ADP
ecj-1449	15	12	2001	2001	NUM
ecj-1449	15	13	by	by	ADP
ecj-1449	15	14	the	the	DET
ecj-1449	15	15	society	society	NOUN
ecj-1449	15	16	of	of	ADP
ecj-1449	15	17	critical	critical	ADJ
ecj-1449	15	18	care	care	NOUN
ecj-1449	15	19	medicine	medicine	NOUN
ecj-1449	15	20	(	(	PUNCT
ecj-1449	15	21	sccm	sccm	PROPN
ecj-1449	15	22	)	)	PUNCT
ecj-1449	15	23	,	,	PUNCT
ecj-1449	15	24	the	the	DET
ecj-1449	15	25	european	european	ADJ
ecj-1449	15	26	society	society	NOUN
ecj-1449	15	27	of	of	ADP
ecj-1449	15	28	intensive	intensive	ADJ
ecj-1449	15	29	care	care	NOUN
ecj-1449	15	30	medicine	medicine	NOUN
ecj-1449	15	31	(	(	PUNCT
ecj-1449	15	32	esicm	esicm	NOUN
ecj-1449	15	33	)	)	PUNCT
ecj-1449	15	34	,	,	PUNCT
ecj-1449	15	35	the	the	DET
ecj-1449	15	36	american	american	PROPN
ecj-1449	15	37	college	college	PROPN
ecj-1449	15	38	of	of	ADP
ecj-1449	15	39	chest	chest	NOUN
ecj-1449	15	40	physicians	physician	NOUN
ecj-1449	15	41	(	(	PUNCT
ecj-1449	15	42	accp	accp	PROPN
ecj-1449	15	43	)	)	PUNCT
ecj-1449	15	44	,	,	PUNCT
ecj-1449	15	45	the	the	DET
ecj-1449	15	46	american	american	PROPN
ecj-1449	15	47	thoracic	thoracic	PROPN
ecj-1449	15	48	society	society	PROPN
ecj-1449	15	49	(	(	PUNCT
ecj-1449	15	50	ats	ats	PROPN
ecj-1449	15	51	)	)	PUNCT
ecj-1449	15	52	,	,	PUNCT
ecj-1449	15	53	and	and	CCONJ
ecj-1449	15	54	the	the	DET
ecj-1449	15	55	surgical	surgical	ADJ
ecj-1449	15	56	infection	infection	NOUN
ecj-1449	15	57	society	society	NOUN
ecj-1449	15	58	(	(	PUNCT
ecj-1449	15	59	sis),8	sis),8	VERB
ecj-1449	15	60	severe	severe	ADJ
ecj-1449	15	61	sepsis	sepsis	NOUN
ecj-1449	15	62	was	be	AUX
ecj-1449	15	63	defined	define	VERB
ecj-1449	15	64	as	as	ADP
ecj-1449	15	65	sepsis	sepsis	NOUN
ecj-1449	15	66	complicated	complicate	VERB
ecj-1449	15	67	by	by	ADP
ecj-1449	15	68	organ	organ	NOUN
ecj-1449	15	69	dysfunction	dysfunction	NOUN
ecj-1449	15	70	and	and	CCONJ
ecj-1449	15	71	septic	septic	ADJ
ecj-1449	15	72	shock	shock	NOUN
ecj-1449	15	73	as	as	ADP
ecj-1449	15	74	a	a	DET
ecj-1449	15	75	state	state	NOUN
ecj-1449	15	76	of	of	ADP
ecj-1449	15	77	acute	acute	ADJ
ecj-1449	15	78	circulatory	circulatory	ADJ
ecj-1449	15	79	failure	failure	NOUN
ecj-1449	15	80	characterized	characterize	VERB
ecj-1449	15	81	by	by	ADP
ecj-1449	15	82	persistent	persistent	ADJ
ecj-1449	15	83	arterial	arterial	ADJ
ecj-1449	15	84	hypotension	hypotension	NOUN
ecj-1449	15	85	unexplained	unexplaine	VERB
ecj-1449	15	86	by	by	ADP
ecj-1449	15	87	other	other	ADJ
ecj-1449	15	88	causes	cause	NOUN
ecj-1449	15	89	.	.	PUNCT
ecj-1449	16	1	hypotension	hypotension	NOUN
ecj-1449	16	2	is	be	AUX
ecj-1449	16	3	defined	define	VERB
ecj-1449	16	4	by	by	ADP
ecj-1449	16	5	a	a	DET
ecj-1449	16	6	systolic	systolic	ADJ
ecj-1449	16	7	arterial	arterial	NOUN
ecj-1449	16	8	pressure	pressure	NOUN
ecj-1449	16	9	below	below	ADP
ecj-1449	16	10	90	90	NUM
ecj-1449	16	11	mm	mm	NUM
ecj-1449	16	12	hg	hg	NOUN
ecj-1449	16	13	(	(	PUNCT
ecj-1449	16	14	or	or	CCONJ
ecj-1449	16	15	,	,	PUNCT
ecj-1449	16	16	in	in	ADP
ecj-1449	16	17	children	child	NOUN
ecj-1449	16	18	,	,	PUNCT
ecj-1449	16	19	<	<	X
ecj-1449	16	20	2	2	NUM
ecj-1449	16	21	sd	sd	NOUN
ecj-1449	16	22	below	below	ADP
ecj-1449	16	23	normal	normal	ADJ
ecj-1449	16	24	for	for	ADP
ecj-1449	16	25	their	their	PRON
ecj-1449	16	26	age	age	NOUN
ecj-1449	16	27	)	)	PUNCT
ecj-1449	16	28	,	,	PUNCT
ecj-1449	16	29	a	a	DET
ecj-1449	16	30	map	map	NOUN
ecj-1449	16	31	<	<	X
ecj-1449	16	32	60	60	NUM
ecj-1449	16	33	,	,	PUNCT
ecj-1449	16	34	or	or	CCONJ
ecj-1449	16	35	a	a	DET
ecj-1449	16	36	reduction	reduction	NOUN
ecj-1449	16	37	in	in	ADP
ecj-1449	16	38	systolic	systolic	ADJ
ecj-1449	16	39	blood	blood	NOUN
ecj-1449	16	40	pressure	pressure	NOUN
ecj-1449	16	41	of	of	ADP
ecj-1449	16	42	>	>	SYM
ecj-1449	16	43	40	40	NUM
ecj-1449	16	44	mm	mm	NOUN
ecj-1449	16	45	hg	hg	NOUN
ecj-1449	16	46	from	from	ADP
ecj-1449	16	47	baseline	baseline	NOUN
ecj-1449	16	48	,	,	PUNCT
ecj-1449	16	49	despite	despite	SCONJ
ecj-1449	16	50	adequate	adequate	ADJ
ecj-1449	16	51	volume	volume	NOUN
ecj-1449	16	52	resuscitation	resuscitation	NOUN
ecj-1449	16	53	,	,	PUNCT
ecj-1449	16	54	in	in	ADP
ecj-1449	16	55	the	the	DET
ecj-1449	16	56	absence	absence	NOUN
ecj-1449	16	57	of	of	ADP
ecj-1449	16	58	other	other	ADJ
ecj-1449	16	59	causes	cause	NOUN
ecj-1449	16	60	for	for	ADP
ecj-1449	16	61	hypotension	hypotension	NOUN
ecj-1449	16	62	.	.	PUNCT
ecj-1449	17	1	although	although	SCONJ
ecj-1449	17	2	still	still	ADV
ecj-1449	17	3	valid	valid	ADJ
ecj-1449	17	4	in	in	ADP
ecj-1449	17	5	essence	essence	NOUN
ecj-1449	17	6	,	,	PUNCT
ecj-1449	17	7	this	this	DET
ecj-1449	17	8	definition	definition	NOUN
ecj-1449	17	9	is	be	AUX
ecj-1449	17	10	not	not	PART
ecj-1449	17	11	sufficiently	sufficiently	ADV
ecj-1449	17	12	precise	precise	ADJ
ecj-1449	17	13	to	to	PART
ecj-1449	17	14	guarantee	guarantee	VERB
ecj-1449	17	15	uniform	uniform	ADJ
ecj-1449	17	16	inclusion	inclusion	NOUN
ecj-1449	17	17	criteria	criterion	NOUN
ecj-1449	17	18	into	into	ADP
ecj-1449	17	19	clinical	clinical	ADJ
ecj-1449	17	20	trials	trial	NOUN
ecj-1449	17	21	.	.	PUNCT
ecj-1449	18	1	let	let	VERB
ecj-1449	18	2	us	we	PRON
ecj-1449	18	3	leave	leave	VERB
ecj-1449	18	4	severe	severe	ADJ
ecj-1449	18	5	sepsis	sepsis	NOUN
ecj-1449	18	6	aside	aside	ADV
ecj-1449	18	7	for	for	ADP
ecj-1449	18	8	a	a	DET
ecj-1449	18	9	moment	moment	NOUN
ecj-1449	18	10	and	and	CCONJ
ecj-1449	18	11	concentrate	concentrate	VERB
ecj-1449	18	12	on	on	ADP
ecj-1449	18	13	septic	septic	ADJ
ecj-1449	18	14	shock	shock	NOUN
ecj-1449	18	15	.	.	PUNCT
ecj-1449	19	1	what	what	PRON
ecj-1449	19	2	should	should	AUX
ecj-1449	19	3	we	we	PRON
ecj-1449	19	4	consider	consider	VERB
ecj-1449	19	5	as	as	ADP
ecj-1449	19	6	an	an	DET
ecj-1449	19	7	adequate	adequate	ADJ
ecj-1449	19	8	volume	volume	NOUN
ecj-1449	19	9	resuscitation	resuscitation	NOUN
ecj-1449	19	10	?	?	PUNCT
ecj-1449	20	1	in	in	ADP
ecj-1449	20	2	2006	2006	NUM
ecj-1449	20	3	,	,	PUNCT
ecj-1449	20	4	the	the	DET
ecj-1449	20	5	emergency	emergency	NOUN
ecj-1449	20	6	department	department	PROPN
ecj-1449	20	7	sepsis	sepsis	NOUN
ecj-1449	20	8	education	education	NOUN
ecj-1449	20	9	program	program	NOUN
ecj-1449	20	10	and	and	CCONJ
ecj-1449	20	11	strategies	strategy	NOUN
ecj-1449	20	12	to	to	PART
ecj-1449	20	13	improve	improve	VERB
ecj-1449	20	14	survival	survival	NOUN
ecj-1449	20	15	(	(	PUNCT
ecj-1449	20	16	ed	ed	NOUN
ecj-1449	20	17	-	-	PUNCT
ecj-1449	20	18	sepsis	sepsis	NOUN
ecj-1449	20	19	)	)	PUNCT
ecj-1449	20	20	working	working	NOUN
ecj-1449	20	21	group	group	NOUN
ecj-1449	20	22	of	of	ADP
ecj-1449	20	23	the	the	DET
ecj-1449	20	24	american	american	PROPN
ecj-1449	20	25	college	college	PROPN
ecj-1449	20	26	of	of	ADP
ecj-1449	20	27	emergency	emergency	NOUN
ecj-1449	20	28	physicians9	physicians9	NOUN
ecj-1449	20	29	stated	state	VERB
ecj-1449	20	30	that	that	SCONJ
ecj-1449	20	31	we	we	PRON
ecj-1449	20	32	should	should	AUX
ecj-1449	20	33	consider	consider	VERB
ecj-1449	20	34	a	a	DET
ecj-1449	20	35	patient	patient	NOUN
ecj-1449	20	36	in	in	ADP
ecj-1449	20	37	septic	septic	ADJ
ecj-1449	20	38	shock	shock	NOUN
ecj-1449	20	39	when	when	SCONJ
ecj-1449	20	40	his	his	PRON
ecj-1449	20	41	/	/	SYM
ecj-1449	20	42	her	her	PRON
ecj-1449	20	43	hypotension	hypotension	NOUN
ecj-1449	20	44	is	be	AUX
ecj-1449	20	45	unresponsive	unresponsive	ADJ
ecj-1449	20	46	to	to	ADP
ecj-1449	20	47	a	a	DET
ecj-1449	20	48	crystalloid	crystalloid	ADJ
ecj-1449	20	49	fluid	fluid	ADJ
ecj-1449	20	50	challenge	challenge	NOUN
ecj-1449	20	51	of	of	ADP
ecj-1449	20	52	20	20	NUM
ecj-1449	20	53	to	to	PART
ecj-1449	20	54	40	40	NUM
ecj-1449	20	55	ml	ml	NOUN
ecj-1449	20	56	/	/	SYM
ecj-1449	20	57	kg	kg	PROPN
ecj-1449	20	58	.	.	PUNCT
ecj-1449	21	1	although	although	SCONJ
ecj-1449	21	2	this	this	PRON
ecj-1449	21	3	is	be	AUX
ecj-1449	21	4	a	a	DET
ecj-1449	21	5	much	much	ADV
ecj-1449	21	6	more	more	ADJ
ecj-1449	21	7	operative	operative	ADJ
ecj-1449	21	8	indication	indication	NOUN
ecj-1449	21	9	,	,	PUNCT
ecj-1449	21	10	it	it	PRON
ecj-1449	21	11	still	still	ADV
ecj-1449	21	12	leaves	leave	VERB
ecj-1449	21	13	us	we	PRON
ecj-1449	21	14	with	with	ADP
ecj-1449	21	15	two	two	NUM
ecj-1449	21	16	problems	problem	NOUN
ecj-1449	21	17	.	.	PUNCT
ecj-1449	22	1	first	first	ADV
ecj-1449	22	2	:	:	PUNCT
ecj-1449	22	3	20	20	NUM
ecj-1449	22	4	to	to	PART
ecj-1449	22	5	40	40	NUM
ecj-1449	22	6	ml	ml	NOUN
ecj-1449	22	7	/	/	SYM
ecj-1449	22	8	kg	kg	PROPN
ecj-1449	22	9	means	mean	VERB
ecj-1449	22	10	anything	anything	PRON
ecj-1449	22	11	between	between	ADP
ecj-1449	22	12	1500	1500	NUM
ecj-1449	22	13	and	and	CCONJ
ecj-1449	22	14	3000	3000	NUM
ecj-1449	22	15	ml	ml	NOUN
ecj-1449	22	16	of	of	ADP
ecj-1449	22	17	saline	saline	NOUN
ecj-1449	22	18	rapidly	rapidly	ADV
ecj-1449	22	19	administered	administer	VERB
ecj-1449	22	20	to	to	ADP
ecj-1449	22	21	an	an	DET
ecj-1449	22	22	average	average	ADJ
ecj-1449	22	23	70	70	NUM
ecj-1449	22	24	kg	kg	NOUN
ecj-1449	22	25	man	man	NOUN
ecj-1449	22	26	.	.	PUNCT
ecj-1449	23	1	not	not	PART
ecj-1449	23	2	a	a	DET
ecj-1449	23	3	little	little	ADJ
ecj-1449	23	4	difference	difference	NOUN
ecj-1449	23	5	.	.	PUNCT
ecj-1449	24	1	second	second	ADV
ecj-1449	24	2	:	:	PUNCT
ecj-1449	24	3	how	how	SCONJ
ecj-1449	24	4	should	should	AUX
ecj-1449	24	5	we	we	PRON
ecj-1449	24	6	consider	consider	VERB
ecj-1449	24	7	colloids	colloid	NOUN
ecj-1449	24	8	,	,	PUNCT
ecj-1449	24	9	which	which	PRON
ecj-1449	24	10	are	be	AUX
ecj-1449	24	11	still	still	ADV
ecj-1449	24	12	widely	widely	ADV
ecj-1449	24	13	used	use	VERB
ecj-1449	24	14	in	in	ADP
ecj-1449	24	15	the	the	DET
ecj-1449	24	16	resuscitation	resuscitation	NOUN
ecj-1449	24	17	of	of	ADP
ecj-1449	24	18	shocked	shocked	ADJ
ecj-1449	24	19	patients	patient	NOUN
ecj-1449	24	20	?	?	PUNCT
ecj-1449	25	1	rules	rule	NOUN
ecj-1449	25	2	of	of	ADP
ecj-1449	25	3	thumb	thumb	NOUN
ecj-1449	25	4	(	(	PUNCT
ecj-1449	25	5	i.e	i.e	ADP
ecj-1449	25	6	100	100	NUM
ecj-1449	25	7	ml	ml	NOUN
ecj-1449	25	8	of	of	ADP
ecj-1449	25	9	colloids	colloid	NOUN
ecj-1449	25	10	equal	equal	VERB
ecj-1449	25	11	300	300	NUM
ecj-1449	25	12	ml	ml	NOUN
ecj-1449	25	13	crystalloids	crystalloid	NOUN
ecj-1449	25	14	)	)	PUNCT
ecj-1449	25	15	do	do	AUX
ecj-1449	25	16	not	not	PART
ecj-1449	25	17	hold	hold	VERB
ecj-1449	25	18	true	true	ADJ
ecj-1449	25	19	in	in	ADP
ecj-1449	25	20	the	the	DET
ecj-1449	25	21	setting	setting	NOUN
ecj-1449	25	22	of	of	ADP
ecj-1449	25	23	microcirculatory	microcirculatory	ADJ
ecj-1449	25	24	and	and	CCONJ
ecj-1449	25	25	endothelial	endothelial	ADJ
ecj-1449	25	26	derangement	derangement	NOUN
ecj-1449	25	27	typical	typical	ADJ
ecj-1449	25	28	of	of	ADP
ecj-1449	25	29	sepsis	sepsis	NOUN
ecj-1449	25	30	and	and	CCONJ
ecj-1449	25	31	have	have	AUX
ecj-1449	25	32	not	not	PART
ecj-1449	25	33	been	be	AUX
ecj-1449	25	34	supported	support	VERB
ecj-1449	25	35	by	by	ADP
ecj-1449	25	36	clinical	clinical	ADJ
ecj-1449	25	37	evidence	evidence	NOUN
ecj-1449	25	38	.	.	PUNCT
ecj-1449	26	1	a	a	DET
ecj-1449	26	2	smaller	small	ADJ
ecj-1449	26	3	span	span	NOUN
ecj-1449	26	4	in	in	ADP
ecj-1449	26	5	fluid	fluid	ADJ
ecj-1449	26	6	deliverance	deliverance	NOUN
ecj-1449	26	7	(	(	PUNCT
ecj-1449	26	8	i.e.	i.e.	X
ecj-1449	26	9	20	20	NUM
ecj-1449	26	10	to	to	PART
ecj-1449	26	11	30	30	NUM
ecj-1449	26	12	ml	ml	NOUN
ecj-1449	26	13	/	/	SYM
ecj-1449	26	14	kg	kg	NOUN
ecj-1449	26	15	)	)	PUNCT
ecj-1449	26	16	and	and	CCONJ
ecj-1449	26	17	a	a	DET
ecj-1449	26	18	clear	clear	ADJ
ecj-1449	26	19	indication	indication	NOUN
ecj-1449	26	20	of	of	ADP
ecj-1449	26	21	crystalloids	crystalloid	NOUN
ecj-1449	26	22	as	as	SCONJ
ecj-1449	26	23	the	the	DET
ecj-1449	26	24	only	only	ADJ
ecj-1449	26	25	fluids	fluid	NOUN
ecj-1449	26	26	to	to	PART
ecj-1449	26	27	use	use	VERB
ecj-1449	26	28	in	in	ADP
ecj-1449	26	29	the	the	DET
ecj-1449	26	30	resuscitation	resuscitation	NOUN
ecj-1449	26	31	phase	phase	NOUN
ecj-1449	26	32	of	of	ADP
ecj-1449	26	33	egdt	egdt	ADJ
ecj-1449	26	34	should	should	AUX
ecj-1449	26	35	be	be	AUX
ecj-1449	26	36	used	use	VERB
ecj-1449	26	37	in	in	ADP
ecj-1449	26	38	the	the	DET
ecj-1449	26	39	future	future	NOUN
ecj-1449	26	40	to	to	PART
ecj-1449	26	41	ease	ease	VERB
ecj-1449	26	42	the	the	DET
ecj-1449	26	43	comparison	comparison	NOUN
ecj-1449	26	44	between	between	ADP
ecj-1449	26	45	clinical	clinical	ADJ
ecj-1449	26	46	studies	study	NOUN
ecj-1449	26	47	.	.	PUNCT
ecj-1449	27	1	one	one	NUM
ecj-1449	27	2	more	more	ADJ
ecj-1449	27	3	problem	problem	NOUN
ecj-1449	27	4	must	must	AUX
ecj-1449	27	5	now	now	ADV
ecj-1449	27	6	be	be	AUX
ecj-1449	27	7	considered	consider	VERB
ecj-1449	27	8	.	.	PUNCT
ecj-1449	28	1	if	if	SCONJ
ecj-1449	28	2	the	the	DET
ecj-1449	28	3	essence	essence	NOUN
ecj-1449	28	4	of	of	ADP
ecj-1449	28	5	shock	shock	NOUN
ecj-1449	28	6	is	be	AUX
ecj-1449	28	7	an	an	DET
ecj-1449	28	8	inadequate	inadequate	ADJ
ecj-1449	28	9	tissue	tissue	NOUN
ecj-1449	28	10	delivery	delivery	NOUN
ecj-1449	28	11	of	of	ADP
ecj-1449	28	12	oxygen	oxygen	NOUN
ecj-1449	28	13	,	,	PUNCT
ecj-1449	28	14	should	should	AUX
ecj-1449	28	15	not	not	PART
ecj-1449	28	16	a	a	DET
ecj-1449	28	17	marker	marker	NOUN
ecj-1449	28	18	of	of	ADP
ecj-1449	28	19	hypoperfusion	hypoperfusion	NOUN
ecj-1449	28	20	be	be	AUX
ecj-1449	28	21	included	include	VERB
ecj-1449	28	22	in	in	ADP
ecj-1449	28	23	the	the	DET
ecj-1449	28	24	definition	definition	NOUN
ecj-1449	28	25	of	of	ADP
ecj-1449	28	26	septic	septic	ADJ
ecj-1449	28	27	shock	shock	NOUN
ecj-1449	28	28	?	?	PUNCT
ecj-1449	29	1	in	in	ADP
ecj-1449	29	2	fact	fact	NOUN
ecj-1449	29	3	,	,	PUNCT
ecj-1449	29	4	this	this	PRON
ecj-1449	29	5	was	be	AUX
ecj-1449	29	6	first	first	ADV
ecj-1449	29	7	done	do	VERB
ecj-1449	29	8	by	by	ADP
ecj-1449	29	9	emmanuel	emmanuel	PROPN
ecj-1449	29	10	rivers	river	NOUN
ecj-1449	29	11	in	in	ADP
ecj-1449	29	12	his	his	PRON
ecj-1449	29	13	reference	reference	NOUN
ecj-1449	29	14	study	study	NOUN
ecj-1449	29	15	published	publish	VERB
ecj-1449	29	16	on	on	ADP
ecj-1449	29	17	the	the	DET
ecj-1449	29	18	new	new	PROPN
ecj-1449	29	19	england	england	PROPN
ecj-1449	29	20	journal	journal	PROPN
ecj-1449	29	21	of	of	ADP
ecj-1449	29	22	medicine	medicine	NOUN
ecj-1449	29	23	in	in	ADP
ecj-1449	29	24	20011	20011	NUM
ecj-1449	29	25	and	and	CCONJ
ecj-1449	29	26	was	be	AUX
ecj-1449	29	27	then	then	ADV
ecj-1449	29	28	taken	take	VERB
ecj-1449	29	29	over	over	ADP
ecj-1449	29	30	by	by	ADP
ecj-1449	29	31	the	the	DET
ecj-1449	29	32	surviving	survive	VERB
ecj-1449	29	33	sepsis	sepsis	NOUN
ecj-1449	29	34	campaign	campaign	NOUN
ecj-1449	29	35	which	which	PRON
ecj-1449	29	36	,	,	PUNCT
ecj-1449	29	37	in	in	ADP
ecj-1449	29	38	its	its	PRON
ecj-1449	29	39	2008	2008	NUM
ecj-1449	29	40	international	international	ADJ
ecj-1449	29	41	guidelines,10	guidelines,10	NOUN
ecj-1449	29	42	stated	state	VERB
ecj-1449	29	43	that	that	SCONJ
ecj-1449	29	44	sepsis	sepsis	NOUN
ecj-1449	29	45	induced	induce	VERB
ecj-1449	29	46	shock	shock	NOUN
ecj-1449	29	47	should	should	AUX
ecj-1449	29	48	be	be	AUX
ecj-1449	29	49	defined	define	VERB
ecj-1449	29	50	as	as	ADP
ecj-1449	29	51	tissue	tissue	NOUN
ecj-1449	29	52	hypoperfusion	hypoperfusion	NOUN
ecj-1449	29	53	(	(	PUNCT
ecj-1449	29	54	hypotension	hypotension	NOUN
ecj-1449	29	55	persisting	persist	VERB
ecj-1449	29	56	after	after	ADP
ecj-1449	29	57	initial	initial	ADJ
ecj-1449	29	58	fluid	fluid	ADJ
ecj-1449	29	59	challenge	challenge	NOUN
ecj-1449	29	60	or	or	CCONJ
ecj-1449	29	61	blood	blood	NOUN
ecj-1449	29	62	lactate	lactate	NOUN
ecj-1449	29	63	concentration	concentration	NOUN
ecj-1449	29	64	>	>	SYM
ecj-1449	29	65	4	4	NUM
ecj-1449	29	66	mmol	mmol	NOUN
ecj-1449	29	67	/	/	SYM
ecj-1449	29	68	l	l	NOUN
ecj-1449	29	69	)	)	PUNCT
ecj-1449	29	70	.	.	PUNCT
ecj-1449	30	1	this	this	PRON
ecj-1449	30	2	would	would	AUX
ecj-1449	30	3	sound	sound	VERB
ecj-1449	30	4	reasonable	reasonable	ADJ
ecj-1449	30	5	if	if	SCONJ
ecj-1449	30	6	high	high	ADJ
ecj-1449	30	7	blood	blood	NOUN
ecj-1449	30	8	lactates	lactate	NOUN
ecj-1449	30	9	were	be	AUX
ecj-1449	30	10	added	add	VERB
ecj-1449	30	11	to	to	ADP
ecj-1449	30	12	unresponsive	unresponsive	ADJ
ecj-1449	30	13	hypotension	hypotension	NOUN
ecj-1449	30	14	in	in	ADP
ecj-1449	30	15	the	the	DET
ecj-1449	30	16	definition	definition	NOUN
ecj-1449	30	17	of	of	ADP
ecj-1449	30	18	septic	septic	ADJ
ecj-1449	30	19	shock	shock	NOUN
ecj-1449	30	20	,	,	PUNCT
ecj-1449	30	21	while	while	SCONJ
ecj-1449	30	22	it	it	PRON
ecj-1449	30	23	leaves	leave	VERB
ecj-1449	30	24	us	we	PRON
ecj-1449	30	25	with	with	ADP
ecj-1449	30	26	some	some	DET
ecj-1449	30	27	open	open	ADJ
ecj-1449	30	28	questions	question	NOUN
ecj-1449	30	29	when	when	SCONJ
ecj-1449	30	30	the	the	DET
ecj-1449	30	31	two	two	NUM
ecj-1449	30	32	conditions	condition	NOUN
ecj-1449	30	33	are	be	AUX
ecj-1449	30	34	proposed	propose	VERB
ecj-1449	30	35	as	as	ADP
ecj-1449	30	36	possible	possible	ADJ
ecj-1449	30	37	alternatives	alternative	NOUN
ecj-1449	30	38	:	:	PUNCT
ecj-1449	30	39	how	how	SCONJ
ecj-1449	30	40	should	should	AUX
ecj-1449	30	41	we	we	PRON
ecj-1449	30	42	consider	consider	VERB
ecj-1449	30	43	hypotensive	hypotensive	ADJ
ecj-1449	30	44	patients	patient	NOUN
ecj-1449	30	45	with	with	ADP
ecj-1449	30	46	normal	normal	ADJ
ecj-1449	30	47	lactates	lactate	NOUN
ecj-1449	30	48	?	?	PUNCT
ecj-1449	31	1	would	would	AUX
ecj-1449	31	2	patients	patient	NOUN
ecj-1449	31	3	who	who	PRON
ecj-1449	31	4	are	be	AUX
ecj-1449	31	5	just	just	ADV
ecj-1449	31	6	hypotensive	hypotensive	ADJ
ecj-1449	31	7	have	have	VERB
ecj-1449	31	8	the	the	DET
ecj-1449	31	9	same	same	ADJ
ecj-1449	31	10	prognosis	prognosis	NOUN
ecj-1449	31	11	of	of	ADP
ecj-1449	31	12	those	those	PRON
ecj-1449	31	13	who	who	PRON
ecj-1449	31	14	are	be	AUX
ecj-1449	31	15	just	just	ADV
ecj-1449	31	16	hyperlactacidemic	hyperlactacidemic	ADJ
ecj-1449	31	17	?	?	PUNCT
ecj-1449	32	1	and	and	CCONJ
ecj-1449	32	2	would	would	AUX
ecj-1449	32	3	the	the	DET
ecj-1449	32	4	combination	combination	NOUN
ecj-1449	32	5	of	of	ADP
ecj-1449	32	6	the	the	DET
ecj-1449	32	7	two	two	NUM
ecj-1449	32	8	add	add	NOUN
ecj-1449	32	9	to	to	ADP
ecj-1449	32	10	global	global	ADJ
ecj-1449	32	11	mortality	mortality	NOUN
ecj-1449	32	12	?	?	PUNCT
ecj-1449	33	1	some	some	DET
ecj-1449	33	2	studies	study	NOUN
ecj-1449	33	3	have	have	AUX
ecj-1449	33	4	tried	try	VERB
ecj-1449	33	5	to	to	PART
ecj-1449	33	6	answer	answer	VERB
ecj-1449	33	7	these	these	DET
ecj-1449	33	8	questions	question	NOUN
ecj-1449	33	9	,	,	PUNCT
ecj-1449	33	10	but	but	CCONJ
ecj-1449	33	11	unfortunately	unfortunately	ADV
ecj-1449	33	12	they	they	PRON
ecj-1449	33	13	have	have	AUX
ecj-1449	33	14	not	not	PART
ecj-1449	33	15	brought	bring	VERB
ecj-1449	33	16	much	much	ADJ
ecj-1449	33	17	light	light	NOUN
ecj-1449	33	18	to	to	ADP
ecj-1449	33	19	the	the	DET
ecj-1449	33	20	scene	scene	NOUN
ecj-1449	33	21	.	.	PUNCT
ecj-1449	34	1	to	to	PART
ecj-1449	34	2	start	start	VERB
ecj-1449	34	3	again	again	ADV
ecj-1449	34	4	from	from	ADP
ecj-1449	34	5	the	the	DET
ecj-1449	34	6	reference	reference	NOUN
ecj-1449	34	7	study	study	NOUN
ecj-1449	34	8	by	by	ADP
ecj-1449	34	9	rivers	river	NOUN
ecj-1449	34	10	et	et	PROPN
ecj-1449	34	11	al	al	PROPN
ecj-1449	34	12	.	.	PROPN
ecj-1449	34	13	,1	,1	PROPN
ecj-1449	35	1	patients	patient	NOUN
ecj-1449	35	2	treated	treat	VERB
ecj-1449	35	3	with	with	ADP
ecj-1449	35	4	egdt	egdt	PROPN
ecj-1449	35	5	had	have	VERB
ecj-1449	35	6	a	a	DET
ecj-1449	35	7	mortality	mortality	NOUN
ecj-1449	35	8	of	of	ADP
ecj-1449	35	9	15	15	NUM
ecj-1449	35	10	%	%	NOUN
ecj-1449	35	11	if	if	SCONJ
ecj-1449	35	12	they	they	PRON
ecj-1449	35	13	had	have	VERB
ecj-1449	35	14	high	high	ADJ
ecj-1449	35	15	lactates	lactate	NOUN
ecj-1449	35	16	but	but	CCONJ
ecj-1449	35	17	no	no	DET
ecj-1449	35	18	hypotension	hypotension	NOUN
ecj-1449	35	19	(	(	PUNCT
ecj-1449	35	20	cryptic	cryptic	ADJ
ecj-1449	35	21	shock	shock	NOUN
ecj-1449	35	22	)	)	PUNCT
ecj-1449	35	23	,	,	PUNCT
ecj-1449	35	24	and	and	CCONJ
ecj-1449	35	25	a	a	DET
ecj-1449	35	26	much	much	ADV
ecj-1449	35	27	higher	high	ADJ
ecj-1449	35	28	moremergency	moremergency	NOUN
ecj-1449	35	29	care	care	NOUN
ecj-1449	35	30	journal	journal	NOUN
ecj-1449	35	31	;	;	PUNCT
ecj-1449	35	32	volume	volume	NOUN
ecj-1449	35	33	9	9	NUM
ecj-1449	35	34	:	:	PUNCT
ecj-1449	35	35	e9	e9	NUM
ecj-1449	35	36	correspondence	correspondence	NOUN
ecj-1449	35	37	:	:	PUNCT
ecj-1449	35	38	daniele	daniele	PROPN
ecj-1449	35	39	coen	coen	PROPN
ecj-1449	35	40	,	,	PUNCT
ecj-1449	35	41	emergency	emergency	NOUN
ecj-1449	35	42	department	department	NOUN
ecj-1449	35	43	,	,	PUNCT
ecj-1449	35	44	niguarda	niguarda	PROPN
ecj-1449	35	45	ca	can	AUX
ecj-1449	35	46	’	'	PUNCT
ecj-1449	35	47	granda	granda	PROPN
ecj-1449	35	48	hospital	hospital	NOUN
ecj-1449	35	49	,	,	PUNCT
ecj-1449	35	50	piazza	piazza	NOUN
ecj-1449	35	51	ospedale	ospedale	NOUN
ecj-1449	35	52	maggiore	maggiore	NOUN
ecj-1449	35	53	3	3	NUM
ecj-1449	35	54	,	,	PUNCT
ecj-1449	35	55	20162	20162	NUM
ecj-1449	35	56	milan	milan	PROPN
ecj-1449	35	57	,	,	PUNCT
ecj-1449	35	58	italy	italy	PROPN
ecj-1449	35	59	.	.	PUNCT
ecj-1449	36	1	tel	tel	PROPN
ecj-1449	36	2	.	.	PUNCT
ecj-1449	37	1	+39.02.64447433	+39.02.64447433	NUM
ecj-1449	37	2	fax	fax	NOUN
ecj-1449	37	3	:	:	PUNCT
ecj-1449	37	4	+39.02.64442825	+39.02.64442825	NUM
ecj-1449	37	5	.	.	PUNCT
ecj-1449	38	1	e	e	X
ecj-1449	38	2	-	-	NOUN
ecj-1449	38	3	mail	mail	NOUN
ecj-1449	38	4	:	:	PUNCT
ecj-1449	38	5	daniele.coen@ospedaleniguarda.it	daniele.coen@ospedaleniguarda.it	PROPN
ecj-1449	38	6	key	key	ADJ
ecj-1449	38	7	words	word	NOUN
ecj-1449	38	8	:	:	PUNCT
ecj-1449	38	9	hyperlactatemia	hyperlactatemia	ADV
ecj-1449	38	10	,	,	PUNCT
ecj-1449	38	11	hypotension	hypotension	NOUN
ecj-1449	38	12	,	,	PUNCT
ecj-1449	38	13	septic	septic	ADJ
ecj-1449	38	14	shock	shock	NOUN
ecj-1449	38	15	,	,	PUNCT
ecj-1449	38	16	early	early	ADJ
ecj-1449	38	17	goal	goal	NOUN
ecj-1449	38	18	directed	direct	VERB
ecj-1449	38	19	therapy	therapy	NOUN
ecj-1449	38	20	.	.	PUNCT
ecj-1449	39	1	conflict	conflict	NOUN
ecj-1449	39	2	of	of	ADP
ecj-1449	39	3	interests	interest	NOUN
ecj-1449	39	4	:	:	PUNCT
ecj-1449	39	5	the	the	DET
ecj-1449	39	6	author	author	NOUN
ecj-1449	39	7	declares	declare	VERB
ecj-1449	39	8	no	no	DET
ecj-1449	39	9	potential	potential	ADJ
ecj-1449	39	10	conflict	conflict	NOUN
ecj-1449	39	11	of	of	ADP
ecj-1449	39	12	interests	interest	NOUN
ecj-1449	39	13	.	.	PUNCT
ecj-1449	40	1	received	receive	VERB
ecj-1449	40	2	for	for	ADP
ecj-1449	40	3	publication	publication	NOUN
ecj-1449	40	4	:	:	PUNCT
ecj-1449	40	5	17	17	NUM
ecj-1449	40	6	march	march	NOUN
ecj-1449	40	7	2013	2013	NUM
ecj-1449	40	8	.	.	PUNCT
ecj-1449	41	1	accepted	accept	VERB
ecj-1449	41	2	for	for	ADP
ecj-1449	41	3	publication	publication	NOUN
ecj-1449	41	4	:	:	PUNCT
ecj-1449	41	5	13	13	NUM
ecj-1449	41	6	may	may	PROPN
ecj-1449	41	7	2013	2013	NUM
ecj-1449	41	8	.	.	PUNCT
ecj-1449	42	1	this	this	DET
ecj-1449	42	2	work	work	NOUN
ecj-1449	42	3	is	be	AUX
ecj-1449	42	4	licensed	license	VERB
ecj-1449	42	5	under	under	ADP
ecj-1449	42	6	a	a	DET
ecj-1449	42	7	creative	creative	ADJ
ecj-1449	42	8	commons	common	NOUN
ecj-1449	42	9	attribution	attribution	NOUN
ecj-1449	42	10	3.0	3.0	NUM
ecj-1449	42	11	license	license	NOUN
ecj-1449	42	12	(	(	PUNCT
ecj-1449	42	13	by	by	ADP
ecj-1449	42	14	-	-	PUNCT
ecj-1449	42	15	nc	nc	PROPN
ecj-1449	42	16	3.0	3.0	NUM
ecj-1449	42	17	)	)	PUNCT
ecj-1449	42	18	.	.	PUNCT
ecj-1449	43	1	©	©	PROPN
ecj-1449	43	2	copyright	copyright	PROPN
ecj-1449	43	3	d.	d.	PROPN
ecj-1449	43	4	coen	coen	PROPN
ecj-1449	43	5	,	,	PUNCT
ecj-1449	43	6	2013	2013	NUM
ecj-1449	43	7	licensee	licensee	NOUN
ecj-1449	43	8	pagepress	pagepress	NOUN
ecj-1449	43	9	,	,	PUNCT
ecj-1449	43	10	italy	italy	PROPN
ecj-1449	43	11	emergency	emergency	PROPN
ecj-1449	43	12	care	care	PROPN
ecj-1449	43	13	journal	journal	PROPN
ecj-1449	43	14	2013	2013	NUM
ecj-1449	43	15	;	;	PUNCT
ecj-1449	43	16	9	9	NUM
ecj-1449	43	17	:	:	PUNCT
ecj-1449	43	18	e9	e9	PROPN
ecj-1449	43	19	doi:10.4081	doi:10.4081	PROPN
ecj-1449	43	20	/	/	SYM
ecj-1449	43	21	ecj.2013.e9	ecj.2013.e9	PROPN
ecj-1449	43	22	non	non	ADJ
ecj-1449	43	23	-co	-co	PROPN
ecj-1449	43	24	mmerc	mmerc	PROPN
ecj-1449	43	25	ial	ial	PROPN
ecj-1449	43	26	us	us	PROPN
ecj-1449	43	27	e	e	NOUN
ecj-1449	43	28	o	o	X
ecj-1449	44	1	nly	nly	ADV
ecj-1449	44	2	[	[	X
ecj-1449	44	3	emergency	emergency	NOUN
ecj-1449	44	4	care	care	NOUN
ecj-1449	44	5	journal	journal	NOUN
ecj-1449	44	6	2013	2013	NUM
ecj-1449	44	7	;	;	PUNCT
ecj-1449	44	8	9	9	NUM
ecj-1449	44	9	:	:	SYM
ecj-1449	44	10	e9	e9	NUM
ecj-1449	44	11	]	]	X
ecj-1449	45	1	[	[	X
ecj-1449	45	2	page	page	NOUN
ecj-1449	45	3	25	25	NUM
ecj-1449	45	4	]	]	PUNCT
ecj-1449	45	5	tality	tality	NOUN
ecj-1449	45	6	(	(	PUNCT
ecj-1449	45	7	42	42	NUM
ecj-1449	45	8	%	%	NOUN
ecj-1449	45	9	)	)	PUNCT
ecj-1449	45	10	if	if	SCONJ
ecj-1449	45	11	they	they	PRON
ecj-1449	45	12	were	be	AUX
ecj-1449	45	13	hypotensive	hypotensive	ADJ
ecj-1449	45	14	(	(	PUNCT
ecj-1449	45	15	this	this	DET
ecj-1449	45	16	group	group	NOUN
ecj-1449	45	17	included	include	VERB
ecj-1449	45	18	both	both	DET
ecj-1449	45	19	patients	patient	NOUN
ecj-1449	45	20	with	with	ADP
ecj-1449	45	21	high	high	ADJ
ecj-1449	45	22	and	and	CCONJ
ecj-1449	45	23	low	low	ADJ
ecj-1449	45	24	levels	level	NOUN
ecj-1449	45	25	of	of	ADP
ecj-1449	45	26	lactate	lactate	NOUN
ecj-1449	45	27	)	)	PUNCT
ecj-1449	45	28	.	.	PUNCT
ecj-1449	46	1	in	in	ADP
ecj-1449	46	2	2011	2011	NUM
ecj-1449	46	3	,	,	PUNCT
ecj-1449	46	4	puskarich	puskarich	PROPN
ecj-1449	46	5	et	et	PROPN
ecj-1449	46	6	al.11	al.11	PROPN
ecj-1449	46	7	addressed	address	VERB
ecj-1449	46	8	the	the	DET
ecj-1449	46	9	problem	problem	NOUN
ecj-1449	46	10	comparing	compare	VERB
ecj-1449	46	11	two	two	NUM
ecj-1449	46	12	groups	group	NOUN
ecj-1449	46	13	of	of	ADP
ecj-1449	46	14	patients	patient	NOUN
ecj-1449	46	15	of	of	ADP
ecj-1449	46	16	similar	similar	ADJ
ecj-1449	46	17	severity	severity	NOUN
ecj-1449	46	18	who	who	PRON
ecj-1449	46	19	differed	differ	VERB
ecj-1449	46	20	in	in	ADP
ecj-1449	46	21	the	the	DET
ecj-1449	46	22	definition	definition	NOUN
ecj-1449	46	23	of	of	ADP
ecj-1449	46	24	shock	shock	NOUN
ecj-1449	46	25	(	(	PUNCT
ecj-1449	46	26	53	53	NUM
ecj-1449	46	27	had	have	VERB
ecj-1449	46	28	cryptic	cryptic	ADJ
ecj-1449	46	29	shock	shock	NOUN
ecj-1449	46	30	with	with	ADP
ecj-1449	46	31	average	average	ADJ
ecj-1449	46	32	lactate	lactate	NOUN
ecj-1449	46	33	values	value	NOUN
ecj-1449	46	34	of	of	ADP
ecj-1449	46	35	5.8	5.8	NUM
ecj-1449	46	36	mmol	mmol	NOUN
ecj-1449	46	37	/	/	SYM
ecj-1449	46	38	l	l	NOUN
ecj-1449	46	39	,	,	PUNCT
ecj-1449	46	40	and	and	CCONJ
ecj-1449	46	41	247	247	NUM
ecj-1449	46	42	had	have	VERB
ecj-1449	46	43	overt	overt	ADJ
ecj-1449	46	44	hypotensive	hypotensive	ADJ
ecj-1449	46	45	shock	shock	NOUN
ecj-1449	46	46	after	after	ADP
ecj-1449	46	47	the	the	DET
ecj-1449	46	48	administration	administration	NOUN
ecj-1449	46	49	of	of	ADP
ecj-1449	46	50	20	20	NUM
ecj-1449	46	51	ml	ml	NOUN
ecj-1449	46	52	/	/	SYM
ecj-1449	46	53	kg	kg	NOUN
ecj-1449	46	54	of	of	ADP
ecj-1449	46	55	fluids	fluid	NOUN
ecj-1449	46	56	with	with	ADP
ecj-1449	46	57	average	average	ADJ
ecj-1449	46	58	lactate	lactate	NOUN
ecj-1449	46	59	values	value	NOUN
ecj-1449	46	60	of	of	ADP
ecj-1449	46	61	2.6	2.6	NUM
ecj-1449	46	62	mmol	mmol	NOUN
ecj-1449	46	63	/	/	SYM
ecj-1449	46	64	l	l	NOUN
ecj-1449	46	65	)	)	PUNCT
ecj-1449	46	66	.	.	PUNCT
ecj-1449	47	1	comparison	comparison	NOUN
ecj-1449	47	2	was	be	AUX
ecj-1449	47	3	made	make	VERB
ecj-1449	47	4	according	accord	VERB
ecj-1449	47	5	to	to	ADP
ecj-1449	47	6	the	the	DET
ecj-1449	47	7	sequential	sequential	ADJ
ecj-1449	47	8	organ	organ	NOUN
ecj-1449	47	9	failure	failure	NOUN
ecj-1449	47	10	assessment	assessment	NOUN
ecj-1449	47	11	(	(	PUNCT
ecj-1449	47	12	sofa	sofa	NOUN
ecj-1449	47	13	)	)	PUNCT
ecj-1449	47	14	and	and	CCONJ
ecj-1449	47	15	simplified	simplify	VERB
ecj-1449	47	16	acute	acute	NOUN
ecj-1449	47	17	physiology	physiology	NOUN
ecj-1449	47	18	score	score	PROPN
ecj-1449	47	19	ii	ii	PROPN
ecj-1449	47	20	(	(	PUNCT
ecj-1449	47	21	saps	sap	NOUN
ecj-1449	47	22	ii	ii	NOUN
ecj-1449	47	23	)	)	PUNCT
ecj-1449	47	24	scores	score	NOUN
ecj-1449	47	25	.	.	PUNCT
ecj-1449	48	1	mortality	mortality	NOUN
ecj-1449	48	2	was	be	AUX
ecj-1449	48	3	around	around	ADV
ecj-1449	48	4	20	20	NUM
ecj-1449	48	5	%	%	NOUN
ecj-1449	48	6	in	in	ADP
ecj-1449	48	7	both	both	DET
ecj-1449	48	8	groups	group	NOUN
ecj-1449	48	9	at	at	ADP
ecj-1449	48	10	variance	variance	NOUN
ecj-1449	48	11	with	with	ADP
ecj-1449	48	12	the	the	DET
ecj-1449	48	13	results	result	NOUN
ecj-1449	48	14	by	by	ADP
ecj-1449	48	15	rivers	river	NOUN
ecj-1449	48	16	et	et	PROPN
ecj-1449	48	17	al	al	PROPN
ecj-1449	48	18	.	.	PUNCT
ecj-1449	49	1	who	who	PRON
ecj-1449	49	2	,	,	PUNCT
ecj-1449	49	3	as	as	SCONJ
ecj-1449	49	4	we	we	PRON
ecj-1449	49	5	said	say	VERB
ecj-1449	49	6	before	before	ADV
ecj-1449	49	7	,	,	PUNCT
ecj-1449	49	8	documented	document	VERB
ecj-1449	49	9	a	a	DET
ecj-1449	49	10	much	much	ADV
ecj-1449	49	11	higher	high	ADJ
ecj-1449	49	12	mortality	mortality	NOUN
ecj-1449	49	13	for	for	ADP
ecj-1449	49	14	hypotensive	hypotensive	ADJ
ecj-1449	49	15	patients	patient	NOUN
ecj-1449	49	16	and	and	CCONJ
ecj-1449	49	17	a	a	DET
ecj-1449	49	18	clear	clear	ADJ
ecj-1449	49	19	difference	difference	NOUN
ecj-1449	49	20	in	in	ADP
ecj-1449	49	21	prognosis	prognosis	NOUN
ecj-1449	49	22	for	for	ADP
ecj-1449	49	23	patients	patient	NOUN
ecj-1449	49	24	in	in	ADP
ecj-1449	49	25	the	the	DET
ecj-1449	49	26	two	two	NUM
ecj-1449	49	27	groups	group	NOUN
ecj-1449	49	28	.	.	PUNCT
ecj-1449	50	1	to	to	PART
ecj-1449	50	2	add	add	VERB
ecj-1449	50	3	confusion	confusion	NOUN
ecj-1449	50	4	to	to	ADP
ecj-1449	50	5	the	the	DET
ecj-1449	50	6	whole	whole	ADJ
ecj-1449	50	7	story	story	NOUN
ecj-1449	50	8	,	,	PUNCT
ecj-1449	50	9	hernandez	hernandez	PROPN
ecj-1449	50	10	et	et	PROPN
ecj-1449	50	11	al.12	al.12	PROPN
ecj-1449	50	12	recently	recently	ADV
ecj-1449	50	13	published	publish	VERB
ecj-1449	50	14	an	an	DET
ecj-1449	50	15	observational	observational	ADJ
ecj-1449	50	16	study	study	NOUN
ecj-1449	50	17	enrolling	enrol	VERB
ecj-1449	50	18	124	124	NUM
ecj-1449	50	19	patients	patient	NOUN
ecj-1449	50	20	admitted	admit	VERB
ecj-1449	50	21	to	to	ADP
ecj-1449	50	22	intensive	intensive	ADJ
ecj-1449	50	23	care	care	NOUN
ecj-1449	50	24	unit	unit	NOUN
ecj-1449	50	25	(	(	PUNCT
ecj-1449	50	26	icu	icu	PROPN
ecj-1449	50	27	)	)	PUNCT
ecj-1449	50	28	for	for	ADP
ecj-1449	50	29	fluid	fluid	ADJ
ecj-1449	50	30	unresponsive	unresponsive	ADJ
ecj-1449	50	31	septic	septic	ADJ
ecj-1449	50	32	shock	shock	NOUN
ecj-1449	50	33	and	and	CCONJ
ecj-1449	50	34	treated	treat	VERB
ecj-1449	50	35	with	with	ADP
ecj-1449	50	36	vasopressors	vasopressor	NOUN
ecj-1449	50	37	.	.	PUNCT
ecj-1449	51	1	among	among	ADP
ecj-1449	51	2	the	the	DET
ecj-1449	51	3	38	38	NUM
ecj-1449	51	4	patients	patient	NOUN
ecj-1449	51	5	with	with	ADP
ecj-1449	51	6	lactates	lactate	NOUN
ecj-1449	51	7	<	<	X
ecj-1449	51	8	2.5	2.5	NUM
ecj-1449	51	9	mmol	mmol	NOUN
ecj-1449	51	10	/	/	SYM
ecj-1449	51	11	l	l	NOUN
ecj-1449	51	12	,	,	PUNCT
ecj-1449	51	13	in	in	ADP
ecj-1449	51	14	-	-	PUNCT
ecj-1449	51	15	hospital	hospital	NOUN
ecj-1449	51	16	mortality	mortality	NOUN
ecj-1449	51	17	was	be	AUX
ecj-1449	51	18	7.9	7.9	NUM
ecj-1449	51	19	%	%	NOUN
ecj-1449	51	20	while	while	SCONJ
ecj-1449	51	21	it	it	PRON
ecj-1449	51	22	was	be	AUX
ecj-1449	51	23	20.9	20.9	NUM
ecj-1449	51	24	%	%	NOUN
ecj-1449	51	25	among	among	ADP
ecj-1449	51	26	the	the	DET
ecj-1449	51	27	86	86	NUM
ecj-1449	51	28	with	with	ADP
ecj-1449	51	29	lactates	lactate	NOUN
ecj-1449	51	30	>	>	SYM
ecj-1449	51	31	2.5	2.5	NUM
ecj-1449	51	32	mmol	mmol	NOUN
ecj-1449	51	33	/	/	SYM
ecj-1449	51	34	l.	l.	NOUN
ecj-1449	51	35	in	in	ADP
ecj-1449	51	36	an	an	DET
ecj-1449	51	37	earlier	early	ADJ
ecj-1449	51	38	retrospective	retrospective	ADJ
ecj-1449	51	39	study	study	NOUN
ecj-1449	51	40	,	,	PUNCT
ecj-1449	51	41	the	the	DET
ecj-1449	51	42	same	same	ADJ
ecj-1449	51	43	authors	author	NOUN
ecj-1449	51	44	had	have	AUX
ecj-1449	51	45	shown	show	VERB
ecj-1449	51	46	even	even	ADV
ecj-1449	51	47	wider	wide	ADJ
ecj-1449	51	48	differences	difference	NOUN
ecj-1449	51	49	in	in	ADP
ecj-1449	51	50	a	a	DET
ecj-1449	51	51	group	group	NOUN
ecj-1449	51	52	of	of	ADP
ecj-1449	51	53	302	302	NUM
ecj-1449	51	54	patients	patient	NOUN
ecj-1449	51	55	adimitted	adimitte	VERB
ecj-1449	51	56	to	to	ADP
ecj-1449	51	57	icu	icu	PROPN
ecj-1449	51	58	for	for	ADP
ecj-1449	51	59	septic	septic	ADJ
ecj-1449	51	60	shock	shock	NOUN
ecj-1449	51	61	.	.	PUNCT
ecj-1449	52	1	mortality	mortality	NOUN
ecj-1449	52	2	was	be	AUX
ecj-1449	52	3	7.7	7.7	NUM
ecj-1449	52	4	%	%	NOUN
ecj-1449	52	5	among	among	ADP
ecj-1449	52	6	the	the	DET
ecj-1449	52	7	104	104	NUM
ecj-1449	52	8	patients	patient	NOUN
ecj-1449	52	9	who	who	PRON
ecj-1449	52	10	never	never	ADV
ecj-1449	52	11	developed	develop	VERB
ecj-1449	52	12	lactates	lactate	NOUN
ecj-1449	52	13	>	>	PUNCT
ecj-1449	52	14	2.4	2.4	NUM
ecj-1449	52	15	mmol	mmol	NOUN
ecj-1449	52	16	/	/	SYM
ecj-1449	52	17	l	l	NOUN
ecj-1449	52	18	,	,	PUNCT
ecj-1449	52	19	and	and	CCONJ
ecj-1449	52	20	42.9	42.9	NUM
ecj-1449	52	21	%	%	NOUN
ecj-1449	52	22	among	among	ADP
ecj-1449	52	23	the	the	DET
ecj-1449	52	24	198	198	NUM
ecj-1449	52	25	patients	patient	NOUN
ecj-1449	52	26	who	who	PRON
ecj-1449	52	27	had	have	VERB
ecj-1449	52	28	a	a	DET
ecj-1449	52	29	value	value	NOUN
ecj-1449	52	30	of	of	ADP
ecj-1449	52	31	lactates	lactate	NOUN
ecj-1449	52	32	>	>	PUNCT
ecj-1449	52	33	2.4	2.4	NUM
ecj-1449	52	34	mmol	mmol	NOUN
ecj-1449	52	35	/	/	SYM
ecj-1449	52	36	l	l	NOUN
ecj-1449	52	37	at	at	ADP
ecj-1449	52	38	least	least	ADJ
ecj-1449	52	39	once	once	ADV
ecj-1449	52	40	in	in	ADP
ecj-1449	52	41	the	the	DET
ecj-1449	52	42	first	first	ADJ
ecj-1449	52	43	24	24	NUM
ecj-1449	52	44	h.13	h.13	NOUN
ecj-1449	52	45	from	from	ADP
ecj-1449	52	46	these	these	DET
ecj-1449	52	47	studies	study	NOUN
ecj-1449	52	48	we	we	PRON
ecj-1449	52	49	can	can	AUX
ecj-1449	52	50	infer	infer	VERB
ecj-1449	52	51	that	that	SCONJ
ecj-1449	52	52	,	,	PUNCT
ecj-1449	52	53	in	in	ADP
ecj-1449	52	54	accordance	accordance	NOUN
ecj-1449	52	55	with	with	ADP
ecj-1449	52	56	a	a	DET
ecj-1449	52	57	wider	wide	ADJ
ecj-1449	52	58	literature	literature	NOUN
ecj-1449	52	59	,	,	PUNCT
ecj-1449	52	60	patients	patient	NOUN
ecj-1449	52	61	with	with	ADP
ecj-1449	52	62	higher	high	ADJ
ecj-1449	52	63	lactates	lactate	NOUN
ecj-1449	52	64	have	have	VERB
ecj-1449	52	65	a	a	DET
ecj-1449	52	66	worse	bad	ADJ
ecj-1449	52	67	prognosis	prognosis	NOUN
ecj-1449	52	68	.	.	PUNCT
ecj-1449	53	1	it	it	PRON
ecj-1449	53	2	seems	seem	VERB
ecj-1449	53	3	also	also	ADV
ecj-1449	53	4	clear	clear	ADJ
ecj-1449	53	5	that	that	SCONJ
ecj-1449	53	6	the	the	DET
ecj-1449	53	7	group	group	NOUN
ecj-1449	53	8	of	of	ADP
ecj-1449	53	9	hypotensive	hypotensive	ADJ
ecj-1449	53	10	patients	patient	NOUN
ecj-1449	53	11	is	be	AUX
ecj-1449	53	12	a	a	DET
ecj-1449	53	13	very	very	ADV
ecj-1449	53	14	heterogeneous	heterogeneous	ADJ
ecj-1449	53	15	one	one	NOUN
ecj-1449	53	16	since	since	SCONJ
ecj-1449	53	17	it	it	PRON
ecj-1449	53	18	may	may	AUX
ecj-1449	53	19	contain	contain	VERB
ecj-1449	53	20	patients	patient	NOUN
ecj-1449	53	21	who	who	PRON
ecj-1449	53	22	are	be	AUX
ecj-1449	53	23	just	just	ADV
ecj-1449	53	24	hypovolemic	hypovolemic	ADJ
ecj-1449	53	25	and	and	CCONJ
ecj-1449	53	26	patients	patient	NOUN
ecj-1449	53	27	who	who	PRON
ecj-1449	53	28	are	be	AUX
ecj-1449	53	29	more	more	ADV
ecj-1449	53	30	or	or	CCONJ
ecj-1449	53	31	less	less	ADV
ecj-1449	53	32	severely	severely	ADV
ecj-1449	53	33	underperfused	underperfused	ADJ
ecj-1449	53	34	.	.	PUNCT
ecj-1449	54	1	these	these	DET
ecj-1449	54	2	groups	group	NOUN
ecj-1449	54	3	of	of	ADP
ecj-1449	54	4	patients	patient	NOUN
ecj-1449	54	5	are	be	AUX
ecj-1449	54	6	likely	likely	ADJ
ecj-1449	54	7	to	to	PART
ecj-1449	54	8	have	have	VERB
ecj-1449	54	9	different	different	ADJ
ecj-1449	54	10	mortality	mortality	NOUN
ecj-1449	54	11	rates	rate	NOUN
ecj-1449	54	12	,	,	PUNCT
ecj-1449	54	13	so	so	SCONJ
ecj-1449	54	14	future	future	ADJ
ecj-1449	54	15	intervention	intervention	NOUN
ecj-1449	54	16	studies	study	NOUN
ecj-1449	54	17	on	on	ADP
ecj-1449	54	18	sepsis	sepsis	NOUN
ecj-1449	54	19	should	should	AUX
ecj-1449	54	20	probably	probably	ADV
ecj-1449	54	21	analyze	analyze	VERB
ecj-1449	54	22	separately	separately	ADV
ecj-1449	54	23	the	the	DET
ecj-1449	54	24	results	result	NOUN
ecj-1449	54	25	obtained	obtain	VERB
ecj-1449	54	26	for	for	ADP
ecj-1449	54	27	the	the	DET
ecj-1449	54	28	groups	group	NOUN
ecj-1449	54	29	of	of	ADP
ecj-1449	54	30	normotensive	normotensive	ADJ
ecj-1449	54	31	/	/	SYM
ecj-1449	54	32	high	high	ADJ
ecj-1449	54	33	lactates	lactate	NOUN
ecj-1449	54	34	,	,	PUNCT
ecj-1449	54	35	hypotensive	hypotensive	ADJ
ecj-1449	54	36	/	/	SYM
ecj-1449	54	37	high	high	ADJ
ecj-1449	54	38	lactates	lactate	NOUN
ecj-1449	54	39	and	and	CCONJ
ecj-1449	54	40	hypotensive	hypotensive	ADJ
ecj-1449	54	41	/	/	SYM
ecj-1449	54	42	low	low	ADJ
ecj-1449	54	43	lactates	lactate	NOUN
ecj-1449	54	44	patients	patient	NOUN
ecj-1449	54	45	.	.	PUNCT
ecj-1449	55	1	conclusions	conclusion	NOUN
ecj-1449	55	2	in	in	ADP
ecj-1449	55	3	conclusion	conclusion	NOUN
ecj-1449	55	4	,	,	PUNCT
ecj-1449	55	5	the	the	DET
ecj-1449	55	6	last	last	ADJ
ecj-1449	55	7	decade	decade	NOUN
ecj-1449	55	8	has	have	AUX
ecj-1449	55	9	seen	see	VERB
ecj-1449	55	10	significant	significant	ADJ
ecj-1449	55	11	advances	advance	NOUN
ecj-1449	55	12	in	in	ADP
ecj-1449	55	13	the	the	DET
ecj-1449	55	14	treatment	treatment	NOUN
ecj-1449	55	15	of	of	ADP
ecj-1449	55	16	septic	septic	ADJ
ecj-1449	55	17	shock	shock	NOUN
ecj-1449	55	18	.	.	PUNCT
ecj-1449	56	1	in	in	ADP
ecj-1449	56	2	the	the	DET
ecj-1449	56	3	near	near	ADJ
ecj-1449	56	4	future	future	NOUN
ecj-1449	56	5	it	it	PRON
ecj-1449	56	6	will	will	AUX
ecj-1449	56	7	be	be	AUX
ecj-1449	56	8	our	our	PRON
ecj-1449	56	9	task	task	NOUN
ecj-1449	56	10	to	to	PART
ecj-1449	56	11	investigate	investigate	VERB
ecj-1449	56	12	more	more	ADV
ecj-1449	56	13	deeply	deeply	ADV
ecj-1449	56	14	the	the	DET
ecj-1449	56	15	different	different	ADJ
ecj-1449	56	16	presentations	presentation	NOUN
ecj-1449	56	17	of	of	ADP
ecj-1449	56	18	this	this	DET
ecj-1449	56	19	syndrome	syndrome	NOUN
ecj-1449	56	20	.	.	PUNCT
ecj-1449	57	1	hopefully	hopefully	ADV
ecj-1449	57	2	,	,	PUNCT
ecj-1449	57	3	this	this	PRON
ecj-1449	57	4	will	will	AUX
ecj-1449	57	5	help	help	VERB
ecj-1449	57	6	us	we	PRON
ecj-1449	57	7	better	well	ADV
ecj-1449	57	8	appreciate	appreciate	VERB
ecj-1449	57	9	the	the	DET
ecj-1449	57	10	studies	study	NOUN
ecj-1449	57	11	that	that	PRON
ecj-1449	57	12	have	have	AUX
ecj-1449	57	13	adopted	adopt	VERB
ecj-1449	57	14	the	the	DET
ecj-1449	57	15	egdt	egdt	ADJ
ecj-1449	57	16	bundle	bundle	NOUN
ecj-1449	57	17	in	in	ADP
ecj-1449	57	18	order	order	NOUN
ecj-1449	57	19	to	to	PART
ecj-1449	57	20	explore	explore	VERB
ecj-1449	57	21	which	which	PRON
ecj-1449	57	22	of	of	ADP
ecj-1449	57	23	its	its	PRON
ecj-1449	57	24	components	component	NOUN
ecj-1449	57	25	are	be	AUX
ecj-1449	57	26	really	really	ADV
ecj-1449	57	27	beneficial	beneficial	ADJ
ecj-1449	57	28	and	and	CCONJ
ecj-1449	57	29	for	for	ADP
ecj-1449	57	30	which	which	DET
ecj-1449	57	31	patients	patient	NOUN
ecj-1449	57	32	.	.	PUNCT
ecj-1449	58	1	references	reference	NOUN
ecj-1449	58	2	1	1	NUM
ecj-1449	58	3	.	.	PUNCT
ecj-1449	59	1	rivers	river	NOUN
ecj-1449	59	2	e	e	PROPN
ecj-1449	59	3	,	,	PUNCT
ecj-1449	59	4	nguyen	nguyen	PROPN
ecj-1449	59	5	b	b	NUM
ecj-1449	59	6	,	,	PUNCT
ecj-1449	59	7	havstad	havstad	NOUN
ecj-1449	59	8	s	s	PROPN
ecj-1449	59	9	,	,	PUNCT
ecj-1449	59	10	et	et	PROPN
ecj-1449	59	11	al	al	PROPN
ecj-1449	59	12	.	.	PUNCT
ecj-1449	60	1	early	early	ADJ
ecj-1449	60	2	goal	goal	NOUN
ecj-1449	60	3	-	-	PUNCT
ecj-1449	60	4	directed	direct	VERB
ecj-1449	60	5	therapy	therapy	NOUN
ecj-1449	60	6	in	in	ADP
ecj-1449	60	7	the	the	DET
ecj-1449	60	8	treatment	treatment	NOUN
ecj-1449	60	9	of	of	ADP
ecj-1449	60	10	severe	severe	ADJ
ecj-1449	60	11	sepsis	sepsis	NOUN
ecj-1449	60	12	and	and	CCONJ
ecj-1449	60	13	septic	septic	ADJ
ecj-1449	60	14	shock	shock	NOUN
ecj-1449	60	15	.	.	PUNCT
ecj-1449	61	1	new	new	ADJ
ecj-1449	61	2	engl	engl	PROPN
ecj-1449	61	3	j	j	PROPN
ecj-1449	61	4	med	me	VERB
ecj-1449	61	5	2001;345:1368	2001;345:1368	PROPN
ecj-1449	61	6	-	-	SYM
ecj-1449	61	7	77	77	NUM
ecj-1449	61	8	.	.	PUNCT
ecj-1449	62	1	2	2	X
ecj-1449	62	2	.	.	X
ecj-1449	62	3	trzeciak	trzeciak	PROPN
ecj-1449	62	4	s	s	PROPN
ecj-1449	62	5	,	,	PUNCT
ecj-1449	62	6	dellinger	dellinger	NOUN
ecj-1449	62	7	rp	rp	NOUN
ecj-1449	62	8	,	,	PUNCT
ecj-1449	62	9	abate	abate	VERB
ecj-1449	62	10	nl	nl	PROPN
ecj-1449	62	11	,	,	PUNCT
ecj-1449	62	12	et	et	PROPN
ecj-1449	62	13	al	al	PROPN
ecj-1449	62	14	.	.	PUNCT
ecj-1449	63	1	translating	translate	VERB
ecj-1449	63	2	research	research	NOUN
ecj-1449	63	3	to	to	ADP
ecj-1449	63	4	clinical	clinical	ADJ
ecj-1449	63	5	practice	practice	NOUN
ecj-1449	63	6	:	:	PUNCT
ecj-1449	63	7	a	a	DET
ecj-1449	63	8	1	1	NUM
ecj-1449	63	9	-	-	PUNCT
ecj-1449	63	10	year	year	NOUN
ecj-1449	63	11	experience	experience	NOUN
ecj-1449	63	12	with	with	ADP
ecj-1449	63	13	implementing	implement	VERB
ecj-1449	63	14	early	early	ADJ
ecj-1449	63	15	goal	goal	NOUN
ecj-1449	63	16	-	-	PUNCT
ecj-1449	63	17	directed	direct	VERB
ecj-1449	63	18	therapy	therapy	NOUN
ecj-1449	63	19	for	for	ADP
ecj-1449	63	20	septic	septic	ADJ
ecj-1449	63	21	shock	shock	NOUN
ecj-1449	63	22	in	in	ADP
ecj-1449	63	23	the	the	DET
ecj-1449	63	24	emergency	emergency	NOUN
ecj-1449	63	25	department	department	NOUN
ecj-1449	63	26	.	.	PUNCT
ecj-1449	64	1	chest	chest	NOUN
ecj-1449	64	2	2006;129:225	2006;129:225	NUM
ecj-1449	64	3	-	-	SYM
ecj-1449	64	4	32	32	NUM
ecj-1449	64	5	.	.	PUNCT
ecj-1449	65	1	3	3	X
ecj-1449	65	2	.	.	X
ecj-1449	65	3	micek	micek	PROPN
ecj-1449	65	4	st	st	PROPN
ecj-1449	65	5	,	,	PUNCT
ecj-1449	65	6	roubinian	roubinian	ADJ
ecj-1449	65	7	h	h	NOUN
ecj-1449	65	8	,	,	PUNCT
ecj-1449	65	9	heuring	heuring	PROPN
ecj-1449	65	10	t	t	PROPN
ecj-1449	65	11	,	,	PUNCT
ecj-1449	65	12	et	et	PROPN
ecj-1449	65	13	al	al	PROPN
ecj-1449	65	14	.	.	PUNCT
ecj-1449	66	1	before	before	ADP
ecj-1449	66	2	-	-	PUNCT
ecj-1449	66	3	after	after	ADP
ecj-1449	66	4	study	study	NOUN
ecj-1449	66	5	of	of	ADP
ecj-1449	66	6	a	a	DET
ecj-1449	66	7	standardized	standardized	ADJ
ecj-1449	66	8	hospital	hospital	NOUN
ecj-1449	66	9	order	order	NOUN
ecj-1449	66	10	set	set	VERB
ecj-1449	66	11	for	for	ADP
ecj-1449	66	12	the	the	DET
ecj-1449	66	13	management	management	NOUN
ecj-1449	66	14	of	of	ADP
ecj-1449	66	15	septic	septic	ADJ
ecj-1449	66	16	shock	shock	NOUN
ecj-1449	66	17	.	.	PUNCT
ecj-1449	67	1	crit	crit	PROPN
ecj-1449	67	2	care	care	PROPN
ecj-1449	67	3	med	me	VERB
ecj-1449	67	4	2006;34:2707	2006;34:2707	PROPN
ecj-1449	67	5	-	-	SYM
ecj-1449	67	6	13	13	NUM
ecj-1449	67	7	.	.	PUNCT
ecj-1449	68	1	4	4	NUM
ecj-1449	68	2	.	.	X
ecj-1449	68	3	jones	jones	PROPN
ecj-1449	68	4	ae	ae	PROPN
ecj-1449	68	5	,	,	PUNCT
ecj-1449	68	6	fochton	fochton	PROPN
ecj-1449	68	7	a	a	PROPN
ecj-1449	68	8	,	,	PUNCT
ecj-1449	68	9	horton	horton	PROPN
ecj-1449	68	10	jm	jm	PROPN
ecj-1449	68	11	,	,	PUNCT
ecj-1449	68	12	et	et	PROPN
ecj-1449	68	13	al	al	PROPN
ecj-1449	68	14	.	.	PROPN
ecj-1449	68	15	prospective	prospective	ADJ
ecj-1449	68	16	external	external	ADJ
ecj-1449	68	17	validation	validation	NOUN
ecj-1449	68	18	of	of	ADP
ecj-1449	68	19	the	the	DET
ecj-1449	68	20	clinical	clinical	ADJ
ecj-1449	68	21	effectiveness	effectiveness	NOUN
ecj-1449	68	22	of	of	ADP
ecj-1449	68	23	an	an	DET
ecj-1449	68	24	emergency	emergency	NOUN
ecj-1449	68	25	department	department	NOUN
ecj-1449	68	26	-	-	PUNCT
ecj-1449	68	27	based	base	VERB
ecj-1449	68	28	early	early	ADJ
ecj-1449	68	29	goal	goal	NOUN
ecj-1449	68	30	-	-	PUNCT
ecj-1449	68	31	directed	direct	VERB
ecj-1449	68	32	therapy	therapy	NOUN
ecj-1449	68	33	protocol	protocol	NOUN
ecj-1449	68	34	for	for	ADP
ecj-1449	68	35	severe	severe	ADJ
ecj-1449	68	36	sepsis	sepsis	NOUN
ecj-1449	68	37	and	and	CCONJ
ecj-1449	68	38	septic	septic	ADJ
ecj-1449	68	39	shock	shock	NOUN
ecj-1449	68	40	.	.	PUNCT
ecj-1449	69	1	chest	chest	NOUN
ecj-1449	69	2	2007;132:425	2007;132:425	NUM
ecj-1449	69	3	-	-	SYM
ecj-1449	69	4	32	32	NUM
ecj-1449	69	5	.	.	PUNCT
ecj-1449	69	6	5	5	NUM
ecj-1449	69	7	.	.	X
ecj-1449	69	8	puskarich	puskarich	PROPN
ecj-1449	69	9	ma	ma	PROPN
ecj-1449	69	10	,	,	PUNCT
ecj-1449	69	11	marchick	marchick	PROPN
ecj-1449	69	12	mr	mr	PROPN
ecj-1449	69	13	,	,	PUNCT
ecj-1449	69	14	kline	kline	PROPN
ecj-1449	69	15	ja	ja	PROPN
ecj-1449	69	16	,	,	PUNCT
ecj-1449	69	17	et	et	PROPN
ecj-1449	69	18	al	al	PROPN
ecj-1449	69	19	.	.	PROPN
ecj-1449	70	1	one	one	NUM
ecj-1449	70	2	year	year	NOUN
ecj-1449	70	3	mortality	mortality	NOUN
ecj-1449	70	4	of	of	ADP
ecj-1449	70	5	patients	patient	NOUN
ecj-1449	70	6	treated	treat	VERB
ecj-1449	70	7	with	with	ADP
ecj-1449	70	8	an	an	DET
ecj-1449	70	9	emergency	emergency	NOUN
ecj-1449	70	10	department	department	NOUN
ecj-1449	70	11	based	base	VERB
ecj-1449	70	12	early	early	ADJ
ecj-1449	70	13	goal	goal	NOUN
ecj-1449	70	14	directed	direct	VERB
ecj-1449	70	15	therapy	therapy	NOUN
ecj-1449	70	16	protocol	protocol	NOUN
ecj-1449	70	17	for	for	ADP
ecj-1449	70	18	severe	severe	ADJ
ecj-1449	70	19	sepsis	sepsis	NOUN
ecj-1449	70	20	and	and	CCONJ
ecj-1449	70	21	septic	septic	ADJ
ecj-1449	70	22	shock	shock	NOUN
ecj-1449	70	23	:	:	PUNCT
ecj-1449	70	24	a	a	DET
ecj-1449	70	25	before	before	ADP
ecj-1449	70	26	and	and	CCONJ
ecj-1449	70	27	after	after	ADP
ecj-1449	70	28	study	study	NOUN
ecj-1449	70	29	.	.	PUNCT
ecj-1449	71	1	crit	crit	PROPN
ecj-1449	71	2	care	care	NOUN
ecj-1449	71	3	2009;13	2009;13	NUM
ecj-1449	71	4	:	:	PUNCT
ecj-1449	71	5	r167	r167	NUM
ecj-1449	71	6	.	.	PROPN
ecj-1449	72	1	6	6	NUM
ecj-1449	72	2	.	.	PUNCT
ecj-1449	72	3	marik	marik	PROPN
ecj-1449	72	4	pe	pe	PROPN
ecj-1449	72	5	,	,	PUNCT
ecj-1449	72	6	baram	baram	PROPN
ecj-1449	72	7	m	m	PROPN
ecj-1449	72	8	,	,	PUNCT
ecj-1449	72	9	vahid	vahid	PROPN
ecj-1449	72	10	b.	b.	PROPN
ecj-1449	72	11	does	do	AUX
ecj-1449	72	12	central	central	ADJ
ecj-1449	72	13	venous	venous	ADJ
ecj-1449	72	14	pressure	pressure	NOUN
ecj-1449	72	15	predict	predict	VERB
ecj-1449	72	16	fluid	fluid	ADJ
ecj-1449	72	17	responsiveness	responsiveness	NOUN
ecj-1449	72	18	?	?	PUNCT
ecj-1449	73	1	a	a	DET
ecj-1449	73	2	systematic	systematic	ADJ
ecj-1449	73	3	review	review	NOUN
ecj-1449	73	4	of	of	ADP
ecj-1449	73	5	the	the	DET
ecj-1449	73	6	literature	literature	NOUN
ecj-1449	73	7	and	and	CCONJ
ecj-1449	73	8	the	the	DET
ecj-1449	73	9	tale	tale	NOUN
ecj-1449	73	10	of	of	ADP
ecj-1449	73	11	seven	seven	NUM
ecj-1449	73	12	mares	mare	NOUN
ecj-1449	73	13	.	.	PUNCT
ecj-1449	74	1	chest	chest	NOUN
ecj-1449	74	2	2008;134:172	2008;134:172	NUM
ecj-1449	74	3	-	-	SYM
ecj-1449	74	4	8	8	NUM
ecj-1449	74	5	.	.	NOUN
ecj-1449	74	6	7	7	X
ecj-1449	74	7	.	.	PUNCT
ecj-1449	74	8	schmidt	schmidt	PROPN
ecj-1449	74	9	ga	ga	PROPN
ecj-1449	74	10	.	.	PROPN
ecj-1449	74	11	counterpoint	counterpoint	NOUN
ecj-1449	74	12	:	:	PUNCT
ecj-1449	74	13	adherence	adherence	NOUN
ecj-1449	74	14	to	to	ADP
ecj-1449	74	15	early	early	ADJ
ecj-1449	74	16	goal	goal	NOUN
ecj-1449	74	17	-	-	PUNCT
ecj-1449	74	18	directed	direct	VERB
ecj-1449	74	19	therapy	therapy	NOUN
ecj-1449	74	20	:	:	PUNCT
ecj-1449	74	21	does	do	AUX
ecj-1449	74	22	it	it	PRON
ecj-1449	74	23	really	really	ADV
ecj-1449	74	24	matter	matter	VERB
ecj-1449	74	25	?	?	PUNCT
ecj-1449	75	1	no	no	INTJ
ecj-1449	75	2	.	.	PUNCT
ecj-1449	76	1	both	both	DET
ecj-1449	76	2	risks	risk	NOUN
ecj-1449	76	3	and	and	CCONJ
ecj-1449	76	4	benefits	benefit	NOUN
ecj-1449	76	5	require	require	VERB
ecj-1449	76	6	further	further	ADJ
ecj-1449	76	7	study	study	NOUN
ecj-1449	76	8	.	.	PUNCT
ecj-1449	77	1	chest	chest	NOUN
ecj-1449	77	2	2010;138:4803	2010;138:4803	NUM
ecj-1449	77	3	.	.	PUNCT
ecj-1449	78	1	8	8	NUM
ecj-1449	78	2	.	.	X
ecj-1449	78	3	levy	levy	NOUN
ecj-1449	78	4	mm	mm	PROPN
ecj-1449	78	5	,	,	PUNCT
ecj-1449	78	6	fink	fink	PROPN
ecj-1449	78	7	mp	mp	PROPN
ecj-1449	78	8	,	,	PUNCT
ecj-1449	78	9	marshall	marshall	PROPN
ecj-1449	78	10	jc	jc	PROPN
ecj-1449	78	11	,	,	PUNCT
ecj-1449	78	12	et	et	PROPN
ecj-1449	78	13	al	al	PROPN
ecj-1449	78	14	.	.	PROPN
ecj-1449	78	15	2001	2001	NUM
ecj-1449	78	16	sccm	sccm	PROPN
ecj-1449	78	17	/	/	SYM
ecj-1449	78	18	esicm	esicm	NOUN
ecj-1449	78	19	/	/	SYM
ecj-1449	78	20	accp	accp	PROPN
ecj-1449	78	21	/	/	SYM
ecj-1449	78	22	ats	ats	PROPN
ecj-1449	78	23	/	/	SYM
ecj-1449	78	24	sis	sis	NOUN
ecj-1449	78	25	international	international	ADJ
ecj-1449	78	26	sepsis	sepsis	NOUN
ecj-1449	78	27	definitions	definition	NOUN
ecj-1449	78	28	conference	conference	NOUN
ecj-1449	78	29	.	.	PUNCT
ecj-1449	79	1	crit	crit	PROPN
ecj-1449	79	2	care	care	PROPN
ecj-1449	79	3	med	me	VERB
ecj-1449	79	4	2003;31:1250	2003;31:1250	NUM
ecj-1449	79	5	-	-	SYM
ecj-1449	79	6	6	6	NUM
ecj-1449	79	7	.	.	NOUN
ecj-1449	79	8	9	9	NUM
ecj-1449	79	9	.	.	PUNCT
ecj-1449	80	1	nguyen	nguyen	PROPN
ecj-1449	80	2	hb	hb	PROPN
ecj-1449	80	3	,	,	PUNCT
ecj-1449	80	4	rivers	river	NOUN
ecj-1449	80	5	ep	ep	PROPN
ecj-1449	80	6	,	,	PUNCT
ecj-1449	80	7	abrahamian	abrahamian	PROPN
ecj-1449	80	8	fm	fm	PROPN
ecj-1449	80	9	,	,	PUNCT
ecj-1449	80	10	et	et	PROPN
ecj-1449	80	11	al	al	PROPN
ecj-1449	80	12	.	.	PROPN
ecj-1449	81	1	severe	severe	ADJ
ecj-1449	81	2	sepsis	sepsis	NOUN
ecj-1449	81	3	and	and	CCONJ
ecj-1449	81	4	septic	septic	ADJ
ecj-1449	81	5	shock	shock	NOUN
ecj-1449	81	6	:	:	PUNCT
ecj-1449	81	7	review	review	NOUN
ecj-1449	81	8	of	of	ADP
ecj-1449	81	9	the	the	DET
ecj-1449	81	10	literature	literature	NOUN
ecj-1449	81	11	and	and	CCONJ
ecj-1449	81	12	emergency	emergency	PROPN
ecj-1449	81	13	department	department	NOUN
ecj-1449	81	14	management	management	NOUN
ecj-1449	81	15	guidelines	guideline	NOUN
ecj-1449	81	16	.	.	PUNCT
ecj-1449	82	1	ann	ann	PROPN
ecj-1449	82	2	emerg	emerg	PROPN
ecj-1449	82	3	med	med	PROPN
ecj-1449	82	4	2006;48:28	2006;48:28	PROPN
ecj-1449	82	5	-	-	PUNCT
ecj-1449	82	6	54	54	NUM
ecj-1449	82	7	.	.	PUNCT
ecj-1449	82	8	10	10	NUM
ecj-1449	82	9	.	.	PUNCT
ecj-1449	83	1	dellinger	dellinger	NOUN
ecj-1449	83	2	rp	rp	NOUN
ecj-1449	83	3	,	,	PUNCT
ecj-1449	83	4	levy	levy	NOUN
ecj-1449	83	5	mm	mm	PROPN
ecj-1449	83	6	,	,	PUNCT
ecj-1449	83	7	carlet	carlet	PROPN
ecj-1449	83	8	jm	jm	PROPN
ecj-1449	83	9	,	,	PUNCT
ecj-1449	83	10	et	et	PROPN
ecj-1449	83	11	al	al	PROPN
ecj-1449	83	12	.	.	PUNCT
ecj-1449	84	1	surviving	survive	VERB
ecj-1449	84	2	sepsis	sepsis	NOUN
ecj-1449	84	3	campaign	campaign	NOUN
ecj-1449	84	4	:	:	PUNCT
ecj-1449	84	5	international	international	ADJ
ecj-1449	84	6	guidelines	guideline	NOUN
ecj-1449	84	7	for	for	ADP
ecj-1449	84	8	management	management	NOUN
ecj-1449	84	9	of	of	ADP
ecj-1449	84	10	severe	severe	ADJ
ecj-1449	84	11	sepsis	sepsis	NOUN
ecj-1449	84	12	and	and	CCONJ
ecj-1449	84	13	septic	septic	ADJ
ecj-1449	84	14	shock	shock	NOUN
ecj-1449	84	15	:	:	PUNCT
ecj-1449	84	16	2008	2008	NUM
ecj-1449	84	17	.	.	PUNCT
ecj-1449	85	1	intens	inten	NOUN
ecj-1449	85	2	care	care	VERB
ecj-1449	85	3	med	med	ADJ
ecj-1449	85	4	2008;34:17	2008;34:17	NUM
ecj-1449	85	5	-	-	SYM
ecj-1449	85	6	60	60	NUM
ecj-1449	85	7	.	.	PUNCT
ecj-1449	86	1	11	11	NUM
ecj-1449	86	2	.	.	X
ecj-1449	87	1	puskarich	puskarich	PROPN
ecj-1449	87	2	ma	ma	PROPN
ecj-1449	87	3	,	,	PUNCT
ecj-1449	87	4	trzeciak	trzeciak	PROPN
ecj-1449	87	5	s	s	PROPN
ecj-1449	87	6	,	,	PUNCT
ecj-1449	87	7	shapiro	shapiro	PROPN
ecj-1449	87	8	ni	ni	PROPN
ecj-1449	87	9	,	,	PUNCT
ecj-1449	87	10	et	et	PROPN
ecj-1449	87	11	al	al	PROPN
ecj-1449	87	12	.	.	PUNCT
ecj-1449	88	1	outcomes	outcome	NOUN
ecj-1449	88	2	of	of	ADP
ecj-1449	88	3	patients	patient	NOUN
ecj-1449	88	4	undergoing	undergo	VERB
ecj-1449	88	5	early	early	ADJ
ecj-1449	88	6	sepsis	sepsis	NOUN
ecj-1449	88	7	resuscitation	resuscitation	NOUN
ecj-1449	88	8	for	for	ADP
ecj-1449	88	9	cryptic	cryptic	ADJ
ecj-1449	88	10	shock	shock	NOUN
ecj-1449	88	11	compared	compare	VERB
ecj-1449	88	12	with	with	ADP
ecj-1449	88	13	overt	overt	ADJ
ecj-1449	88	14	shock	shock	NOUN
ecj-1449	88	15	.	.	PUNCT
ecj-1449	89	1	resuscitation	resuscitation	NOUN
ecj-1449	89	2	2011;82:1289	2011;82:1289	PROPN
ecj-1449	89	3	-	-	SYM
ecj-1449	89	4	93	93	NUM
ecj-1449	89	5	.	.	PUNCT
ecj-1449	90	1	12	12	NUM
ecj-1449	90	2	.	.	PUNCT
ecj-1449	91	1	hernandez	hernandez	PROPN
ecj-1449	91	2	g	g	PROPN
ecj-1449	91	3	,	,	PUNCT
ecj-1449	91	4	bruhn	bruhn	VERB
ecj-1449	91	5	a	a	PRON
ecj-1449	91	6	,	,	PUNCT
ecj-1449	91	7	castro	castro	PROPN
ecj-1449	91	8	r	r	NOUN
ecj-1449	91	9	,	,	PUNCT
ecj-1449	91	10	et	et	PROPN
ecj-1449	91	11	al	al	PROPN
ecj-1449	91	12	.	.	PUNCT
ecj-1449	92	1	persistent	persistent	ADJ
ecj-1449	92	2	sepsis	sepsis	NOUN
ecj-1449	92	3	-	-	PUNCT
ecj-1449	92	4	induced	induce	VERB
ecj-1449	92	5	hypotension	hypotension	NOUN
ecj-1449	92	6	without	without	ADP
ecj-1449	92	7	hyperlactatemia	hyperlactatemia	ADV
ecj-1449	92	8	:	:	PUNCT
ecj-1449	92	9	a	a	DET
ecj-1449	92	10	distinct	distinct	ADJ
ecj-1449	92	11	clinical	clinical	ADJ
ecj-1449	92	12	and	and	CCONJ
ecj-1449	92	13	physiological	physiological	ADJ
ecj-1449	92	14	profile	profile	NOUN
ecj-1449	92	15	within	within	ADP
ecj-1449	92	16	the	the	DET
ecj-1449	92	17	spectrum	spectrum	NOUN
ecj-1449	92	18	of	of	ADP
ecj-1449	92	19	septic	septic	ADJ
ecj-1449	92	20	shock	shock	NOUN
ecj-1449	92	21	.	.	PUNCT
ecj-1449	93	1	crit	crit	PROPN
ecj-1449	93	2	care	care	PROPN
ecj-1449	93	3	res	res	PROPN
ecj-1449	93	4	pract	pract	PROPN
ecj-1449	93	5	2012;2012	2012;2012	PROPN
ecj-1449	93	6	:	:	PUNCT
ecj-1449	93	7	id536852	id536852	NOUN
ecj-1449	93	8	.	.	PUNCT
ecj-1449	94	1	available	available	ADJ
ecj-1449	94	2	from	from	ADP
ecj-1449	94	3	:	:	PUNCT
ecj-1449	94	4	http://www.hindawi.com/journals/ccrp/201	http://www.hindawi.com/journals/ccrp/201	NOUN
ecj-1449	94	5	2/536852/	2/536852/	NUM
ecj-1449	94	6	13	13	NUM
ecj-1449	94	7	.	.	PUNCT
ecj-1449	95	1	hernandez	hernandez	PROPN
ecj-1449	95	2	g	g	PROPN
ecj-1449	95	3	,	,	PUNCT
ecj-1449	95	4	castro	castro	PROPN
ecj-1449	95	5	r	r	PROPN
ecj-1449	95	6	,	,	PUNCT
ecj-1449	95	7	romero	romero	PROPN
ecj-1449	95	8	c	c	PROPN
ecj-1449	95	9	,	,	PUNCT
ecj-1449	95	10	et	et	PROPN
ecj-1449	95	11	al	al	PROPN
ecj-1449	95	12	.	.	PUNCT
ecj-1449	96	1	persistent	persistent	ADJ
ecj-1449	96	2	sepsis	sepsis	NOUN
ecj-1449	96	3	-	-	PUNCT
ecj-1449	96	4	induced	induce	VERB
ecj-1449	96	5	hypotension	hypotension	NOUN
ecj-1449	96	6	without	without	ADP
ecj-1449	96	7	hyperlactatemia	hyperlactatemia	ADV
ecj-1449	96	8	:	:	PUNCT
ecj-1449	96	9	is	be	AUX
ecj-1449	96	10	it	it	PRON
ecj-1449	96	11	really	really	ADV
ecj-1449	96	12	septic	septic	ADJ
ecj-1449	96	13	shock	shock	NOUN
ecj-1449	96	14	?	?	PUNCT
ecj-1449	97	1	j	j	PROPN
ecj-1449	97	2	crit	crit	PROPN
ecj-1449	97	3	care	care	PROPN
ecj-1449	97	4	2011;26:435.e9	2011;26:435.e9	NUM
ecj-1449	97	5	-	-	PUNCT
ecj-1449	97	6	e14	e14	NOUN
ecj-1449	97	7	.	.	PUNCT
ecj-1449	98	1	opinion	opinion	PROPN
ecj-1449	98	2	report	report	PROPN
ecj-1449	98	3	non	non	ADJ
ecj-1449	98	4	-co	-co	PROPN
ecj-1449	98	5	mmerc	mmerc	PROPN
ecj-1449	98	6	ial	ial	PROPN
ecj-1449	99	1	us	us	PROPN
ecj-1449	99	2	e	e	NOUN
ecj-1449	99	3	o	o	NOUN
ecj-1449	100	1	nly	nly	ADV