Hrev_master [Emergency Care Journal 2013; 9:e20] [page 59] Emergency Care Journal; volume 9:e20 A multicenter study on reliability and validity of a new triage system: the Triage Emergency Method version 2 Nicola Parenti,1 Diego Sangiorgi,2 Gianfranco Cervellin,3 Roberta Petrino,4 Gianni Rastelli,5 Gianni Ghetti,3 Mario Cavazza6 1School of Healthcare, University of Parma; 2Biostatistic Research Department, University of Bologna; 3Department of Emergency Medicine, Parma University Hospital; 4Department of Emergency Medicine, Sant’Andrea Hospital, Vercelli; 5Department of Emergency Medicine, Fidenza Hospital; 6Emergency Department, S. Orsola- Malpighi University Hospital, Bologna, Italy Abstract In Italy there are many triage guidelines and methods based on consensus. But, to our knowledge, there are few data on the reliabili- ty and predictive validity of triage systems adopted by Italian emergency departments. The Triage Emergency Method version 2 (TEM v2) is a new four-level in-hospital triage sys- tem. This paper presentes a before-and-after observational study performed using triage scenarios from June 2008 to September 2009 in 6 Italian emergency departments. Twelve nurses who received a 5-h training on TEM and a panel of experts on TEM assigned prior- ity code to 66 scenarios. To test the inter-rater reliability among participants and the panel of experts (before and after the course), we used the weighted K statistic. We assessed the validity of TEM by calculating sensitivity, speci- ficity and accuracy for predicting the reference standard’s triage score. The TEM v2 showed good and very-good agreement among all 6 groups of nurses with a K range=0.61-1. Also, sensitivity, specificity and accuracy of nurses’ triage rating for predicting the reference stan- dard’s triage code was good (accuracy range=78-90%). In this multicenter study, TEM v2 has a good inter-rater reliability for rat- ing triage acuity among all groups of partici- pating nurses, with a K value similar to the ref- erence standard reliability (K=0.75). Thus, the Triage Emergency Method version 2 seems to be valid and accurate in predicting a reference standard rating. Introduction The Triage Emergency Method (TEM), is a new in-hospital triage method based on Italian guidelines.1 It was developed in 2006. In a pre- vious study, it showed a good inter- and intra- rater reliability for rating triage acuity and good accuracy in patient-admission predic- tion.2 TEM v2 contains one flowchart (Figure 1) and a table (Table 1). As shown in Figure 1, this new system is based on an acuity scale, resources used, the time the patient waits to be evaluated, and nursing procedures. It has 4 urgency categories (UC): 1 (Red), immediate assessment; 2 (Yellow), assessment within 20 min; 3 (Green), assessment within 60 min; and 4 (White), assessment within 120 min. In 2008 TEM version 12 was reviewed by 25 Italian experts of triage: 19 nurses and 6 emer- gency physicians.3 After this study, following the experts’ suggestions, TEM version 2 was developed.3 The new TEM v2 showed a good inter-rater reliability for rating triage acuity and good accuracy in predicting the rating of the reference standard also in a group of nurs- ing students.4,5 The aim of this study was to test whether TEM v2 shows a good inter-rater reliability for rating triage acuity and good accuracy in pre- dicting the triage code rating of the reference standard in six groups of nurses from several Italian emergency departments. Materials and Methods Study design and setting This is an observational study performed using triage scenarios from June 2008 to September 2009. Fundamental concepts of triage and the new Triage Emergency Method v2 (Figure 1) were shown, during a 5-h course, to 6 groups of nurses enrolled from 6 Italian emergency departments: Sant’Orsola University Hospital, Bologna; Santa Maria della Scaletta Hospital, Imola; Sant’Andrea Hospital, Vercelli; SS. Pietro e Paolo Hospital, Borgosesia; Parma University Hospital, Parma; and S. Secondo Hospital, Fidenza. Data collection We used 66 triage scenarios from a database used in previous studies.2,4,5 We recorded the following data: demographic and clinical char- acteristics, original nurse’s triage category, admission status and site, and the data on triage forms completed by the nurse, namely, presenting complaint, mode and time of arrival, past diseases, vital signs, and pain score. Each case given to the study partici- pants included the patient’s age and gender, presenting complaint, a brief case scenario with mode and time of arrival, past diseases, vital signs, and pain score. Study participants Twelve nurses (2 for each hospital) who worked in the emergency departments were assigned to undergo a five-hour training in triage and TEM. Four senior triage nurses and one doctor, who had emergency nursing and teaching triage certification, more than 15 years of emergency nursing experience, and prolonged training in the new triage method (TEM), comprised the panel of triage experts. The panel independently assigned, using TEM, triage scores to the 66 scenarios. Their triage codes were the reference standard (RS) for the triage level in this study. They were blinded to the triage category assigned both by the origi- nal triage nurse and by the nurses involved in this study. The nurses enrolled in the study completed a questionnaire related to their demographics, education, and work experi- ence. Study protocol Between June 2008 and September 2009 a 5- h course on triage (1 h) and TEM (4 h) was per- formed in the hospitals enrolled. Each partici- pant independently assigned triage scores to the 66 scenarios before the course (T0) and three months after the course (T1). To prevent communication between participants, the stu- dents assigned triage codes in different rooms and in the presence of two investigators. The triage scenarios were given randomly to the participants. During the second test, three Correspondence: Nicola Parenti, School of Healthcare, University of Parma, via Gramsci 14, 43100 Parma, Italy. Tel./Fax: +39.051.9912065. E-mail: nipar71@yahoo.it Key words: triage, emergency department, relia- bility, predictive validity. Contributions: NP conceived the study, designed it, collected and managed the data. Other authors contributed equally. Conflict of interests: the authors declare no potential conflict of interest. Received for publication: 27 June 2013. Revision received: 26 August 2013. Accepted for publication: 26 August 2013. This work is licensed under a Creative Commons Attribution 3.0 License (by-nc 3.0). ©Copyright N. Parenti et al., 2013 Licensee PAGEPress, Italy Emergency Care Journal 2013; 9:e20 doi:10.4081/ecj.2013.e20 Non -co mmerc ial us e o nly [page 60] [Emergency Care Journal 2013; 9:e20] Article months after the course, participants could con- sult the TEM flowchart (Figure 1 and Table 1). The data were collected and entered on a spreadsheet by an investigator who was blind to the aim of the study. The nurses’ group remained concealed during data entry and analysis. Being a quality assurance investiga- tion, without access to patient’s data, the insti- tutions exempted the study from formal review. The nurses involved in the study gave informed consent and permission to access their data. Data analysis To test the quality of rating triage code by the group of participants, we choose the inter- rater reliability before and after the course and we assessed the validity of TEM. Reliability was measured with weighted K by comparing the triage nurses’ rating (inter- rater) at T0 and T1. We also measured the inter-rater reliability between the group and its reference standard by measuring the weighted K against the urgency category assigned by the panel of triage experts. In accordance with the literature,6 we consider a K value between 0.00 to 0.20 to be poor agreement, a K value between 0.20 and 0.60 to be fair to moderate agreement, a K value between 0.60 and 0.80 to be good agreement, and a K value between 0.80 and 1 to be very good agreement. We evaluated the validity of TEM by calculat- ing sensitivity, specificity and accuracy for pre- diction of the reference standard’s triage score. To analyze the predictive validity for the reference standard’s triage score, for each sce- nario we considered the mode of the urgency category assigned by the nurses, and we used this code in all validity calculations. We evalu- ated the validity by calculating sensitivity and specificity for prediction of reference stan- dard’s triage score using the following cut-offs: true codes 1 and 2=patient sick and likely to be admitted; true code 3 and 4=less urgency. We calculated participant and scenarios sample size according to Rotondi et al.,7 antic- ipating a standard error of 0.05. Statistical sig- nificance was tested at an alpha level=0.05. We used the STATA v9.2 software (Statacorp, College Station Texas, USA) for statistical analysis. Results Of the 66 patients included in triage scenar- ios, 44% were women, and the mean age was 39 years (SD±27.5). The most frequent symp- toms were minor trauma (19%) and pain (14%). Seven hospital admissions were recorded: six in non-intensive wards and one in intensive care units. The group of twelve participants had good experience in nursing (median: 6 years; range 3-15) with a median of 4 years in emergency triage. The rate of urgency categories at T0 (with- out TEM v2) and T1 (with TEM v2) assigned to each scenario was similar between the triage panel experts and the nurses enrolled (Figure 2). The green code (code 3) was most preva- lent. There was an overtriage and undertriage (with respect to the reference standard assign- ment) of 8 and 11% among nurses who used TEM v2. In particular, 2 of the 7 undertriage cases were for code 2, and 1 of the 7 were for code 1. All overtriage cases were for code 4. Table 1. Triage emergency method patient’s main complaints. Code Situation guide Symptom Red Very high risk situations Severe acute pain (VAS=9-10); shock; AMI arrhythmia: actual chest pain with syncope and/or arrhythmia and/or dyspnea; aphasia and/or numbness <3 h; dyspnea with wheeze or laryngospasm; major trauma: pen trating injury, severe facial trauma or cranial trauma with GCS≤14, thoracic trauma with volet or dyspnea, abdominal trauma with SBP ≤90 mmHg, rachis trauma with sensitive-motor deficit, amputation of long bones, open fractures of long bones, 2nd or 3rd degree skin burns (>30% adult or >20% babies), eyes or airway burns, RTS≤10; multiple trauma with major mechanisms (fall from 5 m; ejection outside a vehicle, or pedestrian run down, age <5 years); severe intoxication (quantity or kind of substance or substance unknown) with dysphonia, dysphagia, chest or abdominal pain; status epilepticus; headache with altered level of consciousness or meningism, seizures or syncope; hematemesis or other severe haemorrhage in action; severe allergic reactions with dyspnea, dysphonia or severe hypotension; emergency delivery; eclampsia; severe vaginal bleeding Children: severe dehydration, headache with GCS≤14 or lethargy or hypotonia, abuse Yellow High risk situations Cardiac: chest pain≤6 h, syncope, arrhythmia, limbs ischemia, hypertension crisis (SBP>200 mmHg), unstable hypotension (SBP<100mmHg) Pneumology: mild dyspnea (SaO2 88-92%) Abdomen: acute abdominal pain, vomit and diarrhea with dehydration, hypovolemia (hypotension-tachycardia), hematemesis, melena, severe rectal bleeding in action Neurology: headache or with SBP>200 mmHg, headache after cranial trauma if anticoagulants; consciousness alterations (agitation, drowsiness, acute confusion), GCS 8-14, aphasia or sensitive-motor deficit <3 h, convulsions; alcohol or drug abuse; severe dizziness/vertigo or with headache or motor deficit; moderate pain (VAS=7-8); minor intoxication, severe allergic reactions (extensive nettle rash, dysphonia, angioedema, multiple hymenoptera stings in history of anaphylaxis) Infections: fever with lethargy, severe infection (rash or purpura), temperature >39°C, fever in immunodeficiency; trauma: concussive cranial trauma or anticoagulants, long bones, dislocation, bone deformation, open fractures, severe lacerations, crush syndrome, limb trauma without pulse, multiple trauma, major dynamic; acute lumbar pain (if age >40yrs or in case of hypertension); severe glycemic failure in diabetes (40 mg/dL300 mg/dL); sexual assault, severe or painful haemorrhage or mild but persistent in anticoagulants or hypertension crisis; renal-genitourinary: scrotum pain, anuria or oliguria Gynaecology and obstetrics: vaginal bleeding in the elderly or pregnancy with pain, delivery with active contractions <5 min, pre-eclampsia, pelvic pain Eye: eye injury with alkali or acid, visual deficit; psychiatric symptoms in patient suffering from mental illness; severe or mild haemorrhage (any cause) Child: newborn <3 months; moderate dehydration, severe vomiting or diarrhea; recent trauma <12 h; neonatal crying, recent convulsion VAS, visual analogic scale; AMI, acute myocardial ischemia; GCS, Glasgow coma score; SBP, systolic blood pressure; RTS, revised trauma score; SaO2 (%), percentage of oxygen saturation. Non -co mmerc ial us e o nly [Emergency Care Journal 2013; 9:e20] [page 61] Article Complete disagreement (when nurses of the same group assigned to the same scenario triage codes that differed in more than two pri- ority levels, e.g. one nurse assigned level 4, and another, level 1) and complete agreement (when all nurses enrolled assigned the same triage code) occurred in 8 and 17%, respective- ly, of scenarios evaluated with TEM v2. Inter-rater reliability among nurses who assigned priority code to 66 scenarios using the triage systems of their emergency depart- ments and TEM v2 is shown in Table 2. TEM v2 showed good and very good agreement among all emergency departments with a K range=0.61-1 (Table 2). Also sensitivity, speci- ficity and accuracy of nurses’ triage rating for predicting the reference standard’s triage code was good (Table 3). Discussion In all six groups of nurses, TEM v2 showed good to very good inter-rater reliability and good accuracy in predicting the reference stan- dard’s rating. Its performance was good despite the nurses’ lack of experience using TEM. In addition, the Triage Emergency Method has the advantage of predicting resource utiliza- tion in the emergency department. After a brief course, TEM v2 reached reliabil- ity performances similar to those of traditional triage systems (Table 2). The six groups of nurses who used TEM proved accurate in predicting the reference standard’s triage code: accuracy range=78-90% (Table 3). Few previous studies used a refer- ence standard to test the validity of a triage system.8,9 However, it’s very difficult to estab- lish validity criteria for triage acuity classifica- tion in the absence of a clear reference stan- dard. For this reason we tried to develop a sur- rogate gold standard based on a panel consen- sus, and we tested the predictive validity of our triage system against this gold standard. It is difficult to compare our results on valid- ity with previous studies because of the differ- ences in the setting and the type of triage sys- tem (five levels compared to four levels). Nevertheless, our results on validity and relia- bility of TEM are similar to previous studies on emergency severity index v410-12 and the Canadian triage acuity scale.13 In accordance with a previous Italian study, the most frequent priority code was green. TEM is a four-level acuity triage system, based on Italian guidelines.1 It was developed by 25 Italian experts of triage (emergency doctors and nurses). It is original because its sample struc- ture (one flow chart and one table) is clear and sample to teach, memorize and consult.2-5 Moreover, it is the first Italian triage model that includes a resources evaluation; it is simple and Figure 1. Flowchart of the Triage Emergency Method version 2. Figure 2. Rate of urgency categories assigned to each scenario. Non -co mmerc ial us e o nly [page 62] [Emergency Care Journal 2013; 9:e20] Article fast to assign the lower priority codes because the assignment is based on the estimation of resources necessary to the patient evaluated at triage. Finally, to our knowledge, the TEM v2 is the first Italian triage model who showed a good validity and reliability in more studies conduct- ed with several kind of participants (student, nurses) in more settings. The main limitation of our study is that it was conducted with paper scenarios and not with patients; however, this procedure has been used and validated in other studies on inter-rater reliability of triage tools.10- 13 The main limits of TEM v2 are that it is a the- oretical model without feasibility studies and that the table for higher priority codes (red and yellow) could slow down the assignment. Conclusions In conclusion, to our knowledge, this is the first Italian multicenter study that tests the reliability and validity of a 4-level triage sys- tem. It seems that TEM v2 has good inter-rater reliability for rating triage acuity among all groups of nurses enrolled (K inter range=0.6- 1). This K value is similar to the reference standard reliability (K=0.75). In this study, the TEM v2 seems to be valid and accurate in pre- dicting a reference standard rating. Other studies with a wider sample of triage scenarios and more nurses (raters) participating would be necessary to confirm these results. References 1. Italian Ministry of Health. [Triage intrao- spedaliero nel sistema dell’emergenza- urgenza sanitaria]. [Regulation in Italian]. Regulation n. 285/7712/2001. Rome: Italian Ministry of Health ed.; 2001. 2. Parenti N, Ferrara L, Bacchi Reggiani ML, et al. Reliability and validity of two four- level emergency triage systems. Eur J Emerg Med 2009;16:115-20. 3. Parenti N, Serventi V, Miglio R, et al. [Il Triage Emergency Method versione 2 (TEM v2). Un nuovo modello di triage intraospedaliero]. Emerg Care J 2011;3:27-34. 4. Parenti N, Bacchi Reggiani ML, Sangiorgi D, et al. [Affidabilità e validità di un nuovo metodo di triage intraospedaliero: il Triage Emergency Method in un gruppo di stu- denti universitari]. [Article in Italian]. SIMEU Journal 2011;3:20-1. 5. Parenti N, Bacchi Reggiani ML, Sangiorgi D, et al. Effect of a triage course on quali- ty of rating triage codes in a group of uni- versity nursing students: a before-after observational study. World J Emerg Med 2013;4:20-5. 6. Fernandes C, Tanabe P, Gilboy N, et al. Five-level triage: a report from the ACEP/ENA five-level triage task force. J Emerg Nurs 2005;31:39-50. 7. Rotondi MA, Donner A. A confidence inter- val approach to sample size estimation for interobserver agreement studies with multiple raters and outcomes. J Clin Epidemiol 2012;65:778-84. 8. Storm-Versloot MN, Ubbink DT, Chin a Choi V, et al. Observer agreement of the Manchester triage system and the emer- gency severity index: a simulation study. Emerg Med J 2009;26:556-60. 9. van der Wulp I, Schrijvers A JP, van Stel HF. Predicting admission and mortality with the emergency severity index and the Manchester triage system: a retrospective observational study. Emerg Med J 2009;26:506-9. 10. Eitel DR, Travers DA, Rosenau AM, et al. The emergency severity index triage algo- rithm version 2 is reliable and valid. Acad Emerg Med 2003;10:1070-80. 11. Tanabe P, Gimbel R, Yarnold PR, et al. Reliability and validity of scores on the emergency severity index version 3. Acad Emerg Med 2004;11:59-65. 12. Wuerz RC, Milne LW, Eitel DR, et al. Reliability and validity of a new five-level triage instrument. Acad Emerg Med 2000;7:236-42. 13. Beveridge R. CAEP issues. The Canadian triage and acuity scale: a new and critical element in health care reform. J Emerg Med 1998;16:507-11. Table 2. Inter-rater reliability of triage methods and Triage Emergency Method version 2. Group 1 Group 2 Group 3 Group 4 Group 5 Group 6 Met 1 TEM Met 2 TEM Met 3 TEM Met 4 TEM Met 5 TEM Met 6 TEM Weighted K inter-range* 0.71 0.75 0.80 1 0.69 0.61 0.76 1 0.98 0.84 0.25 0.79 Complete agreement (%)° 64 73 68 100 68 35 74 100 94 83 41 82 Complete disagreement (%)# 2 0 4 0 0 3 0 0 0 0 2 2 Met, triage method used in 12 emergency departments; TEM, triage emergency method version 2. *K inter-range 0-1 (0= scarse agreement, 1=maximum agreement); °when all 12 nurses enrolled assigned the same triage code; #when nurses of the same group assigned to the same scenario triage codes that differed in more than two priority levels, e.g. one nurse assigned level 4 and another assigned level 1. Table 3. Validity of the Triage Emergency Method version 2 for prediction of the reference standard’s rating. Group 1 Group 2 Group 3 Group 4 Group 5 Group 6 Accuracy (95% CI) 0.78 (0.51-1.05) 0.79 (0.57-1.00) 0.90 (0.71-1.09) 0.79 (0.57-1.00) 0.83 (0.62-1.04) 0.86 (0.67-1.04) Sensitivity (95% CI) 1 .00 (1.00-1.00) 1.00 (1.00-1.00) 1.00 (1.00-1.00) 0.98 (0.94-1.02) 1.00 (1.00-1.00) 1.00 (1.00-1.00) Specificity (95% CI) 0.97 (0.92-1.01) 0.95 (0.90-1.00) 0.98 (0.94-1.02) 0.94 (0.88-1.00) 0.97 (0.92-1.01) 0.97 (0.92-1.01) PPV (95% CI) 1 .00 (1.00-1.00) 1.00 (1.00-1.00) 1.00 (1.00-1.00) 0.92 (0.76-1.07) 1.00 (1.00-1.00) 1.00 (1.00-1.00) NPV (95% CI) 0.96 (0.91-1.01) 0.94 (0.88-1.01) 0.97 (0.92-1.02) 0.94 (0.88-1.01) 0.96 (0.91-1.01) 0.96 (0.91-1.01) CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value. We tested the accuracy, sensitivity, specificity, PPV, and NPV among groups of nurses in each emergency department using TEM v2 to predict the reference standard’s rating. Non -co mmerc ial us e o nly