# bib

id: cord-293500-z28bws23
author: Guan, Wei-jie
title: Cardiovascular comorbidity and its impact on patients with Covid-19
date: 2020-04-27
extension: .txt
mime: text/plain
words: 463
sentence: 17
flesch: 27
cache: cache/cord-293500-z28bws23.txt
txt: txt/cord-293500-z28bws23.txt
summary:
  We truly appreciate the comments from Sisnieguez et al., who have performed a further analysis on the potential association between cardiovascular comorbidities and the clinical outcomes of Covid-19 (in particular, the mortality) We also applaud the suggestion to thoroughly adjust for the potential confounding factors when interpreting the association between specific categories of cardiovascular comorbidities (e.g., hypertension) and the clinical outcomes of Covid-19.


id: cord-290378-h4cof32m
author: Guy, Tiphaine
title: High-flow nasal oxygen: a safe, efficient treatment for COVID-19 patients not in an ICU
date: 2020-08-28
extension: .txt
mime: text/plain
words: 1396
sentence: 55
flesch: 47
cache: cache/cord-290378-h4cof32m.txt
txt: txt/cord-290378-h4cof32m.txt
summary:
  Of the 4 unweaned patients, 2 remained on HFNO unit and 2 were transferred to the ICU. Above all, the experience of HCWs with HFNO management and continued training in anti-airborne precautions undoubtedly help minimize the risk of contamination in the respiratory unit.


id: cord-316058-eh4m5jqz
author: Long, Li
title: Short-term Outcomes of Coronavirus Disease 2019 and Risk Factors for Progression
date: 2020-04-20
extension: .txt
mime: text/plain
words: 1564
sentence: 62
flesch: 48
cache: cache/cord-316058-eh4m5jqz.txt
txt: txt/cord-316058-eh4m5jqz.txt
summary:
  Moderate cases were defined when patients presented with fever and/or respiratory symptoms and have a radiographic appearance of pneumonia. As far as we know, this is the first study that focuses on clinical outcomes of COVID-19 patients rated as different severities on admission.


id: cord-325565-cz9f65ca
author: Heederik, Dick J.J.
date: 2020-06-25
extension: .txt
mime: text/plain
words: 2063
sentence: 64
flesch: 36
cache: cache/cord-325565-cz9f65ca.txt
txt: txt/cord-325565-cz9f65ca.txt
title:
  Go slow to go fast: A plea for sustained scientific rigor in air pollution research during the COVID-19 pandemic

summary:
  Thus, there seems little reason to abandon the rigorous peer review process and expedite manuscript publication for COVID-19 air pollution studies. This far exceeds the granularity of the data used in air pollution studies and most infectious disease outbreak studies.


id: cord-333131-affb4yln
author: Jacob, Joseph
date: 2020
extension: .txt
mime: text/plain
words: 1668
sentence: 57
flesch: 33
cache: cache/cord-333131-affb4yln.txt
txt: txt/cord-333131-affb4yln.txt
title:
  Using imaging to combat a pandemic: rationale for developing the UK National COVID-19 Chest Imaging Database

summary:
  key: cord-333131-affb4yln authors: Jacob, Joseph; Alexander, Daniel; Baillie, J. Kenneth; Berka, Rosalind; Bertolli, Ottavia; Blackwood, James; Buchan, Iain; Bloomfield, Claire; Cushnan, Dominic; Docherty, Annemarie; Edey, Anthony; Favaro, Alberto; Gleeson, Fergus; Halling-Brown, Mark; Hare, Samanjit; Jefferson, Emily; Johnstone, Annette; Kirby, Myles; Mcstay, Ruth; Nair, Arjun; Openshaw, Peter J.M.; Parker, Geoff; Reilly, Gerry; Robinson, Graham; Roditi, Giles; Rodrigues, Jonathan C.L.; Sebire, Neil; Semple, Malcolm G.; Sudlow, Catherine; Woznitza, Nick; Joshi, Indra title: Using imaging to combat a pandemic: rationale for developing the UK National COVID-19 Chest Imaging Database date: 2020 journal: Eur Respir J DOI: 10.1183/13993003.01809-2020 sha: doc_id: 333131 cord_uid: affb4yln The National COVID-19 Chest Imaging Database (NCCID) is a repository of chest X-Ray, CT and MRI images and clinical data from COVID-19 patients across the UK, to support research and development of AI technology that may proffer insights into the disease. The scale of the COVID-19 pandemic has resulted in the acquisition of huge volumes of imaging data.


id: cord-290490-u3mkfvxw
author: Armstrong-James, Darius
title: Confronting and mitigating the risk of COVID-19 Associated Pulmonary Aspergillosis (CAPA)
date: 2020-07-23
extension: .txt
mime: text/plain
words: 2299
sentence: 58
flesch: 20
cache: cache/cord-290490-u3mkfvxw.txt
txt: txt/cord-290490-u3mkfvxw.txt
summary:
  Although performance might be superior to serum Aspergillus antigen testing for the detection of IPA in the ICU (28), BDG negativity cannot be used to rule out infection, with a 77% sensitivity determined across a heterogeneous population of IA patients, and performance in CAPA as yet to be determined. Fungal infections present an additional threat in the challenging task of managing COVID-19 patients in outbreak conditions.


id: cord-281193-sb7kgu24
author: Yang, Hai-Jun
date: 2020-08-03
extension: .txt
mime: text/plain
words: 227
sentence: 6
flesch: 42
cache: cache/cord-281193-sb7kgu24.txt
txt: txt/cord-281193-sb7kgu24.txt
title:
  Re: Predictors of mortality for patients with COVID-19 pneumonia caused by SARSCoV-2: a prospective cohort study

summary:
  We hope our comments will be helpful to improve the expression and increase the quality of the paper published by Du R et al. Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study Methods for estimating the case fatality ratio for a novel, emerging infectious disease [2] . Taken together, the findings of the study reported by Du R et al are of great significance, though some possible error and inappropriate expression were found.


id: cord-307732-sdstnm9i
author: Yang, Kai
title: The influence of preventive strategies on COVID-2019 epidemic in Shenzhen, China
date: 2020-04-16
extension: .txt
mime: text/plain
words: 1046
sentence: 36
flesch: 45
cache: cache/cord-307732-sdstnm9i.txt
txt: txt/cord-307732-sdstnm9i.txt
summary:
  In the decline phase, the number of daily new confirmed cases decreased All medical staff involved in the management of COVID-19 patients implemented infection control procedures. key: cord-307732-sdstnm9i authors: Yang, Kai; Wang, Lingwei; Li, Furong; Chen, Dandan; Li, Xi; Qiu, Chen; Chen, Rongchang title: The influence of preventive strategies on COVID-2019 epidemic in Shenzhen, China date: 2020-04-16 journal: Eur Respir J DOI: 10.1183/13993003.00599-2020 sha: doc_id: 307732 cord_uid: sdstnm9i Early identification of imported cases, prevention of family clustering transmission, preventive measures in the public area and strict infection control procedure in hospitals were crucial for successful prevention of COVID-19 in Shenzhen, China.


id: cord-327169-sz4ildnd
author: Mondoni, Michele
date: 2020-08-28
extension: .txt
mime: text/plain
words: 1348
sentence: 60
flesch: 35
cache: cache/cord-327169-sz4ildnd.txt
txt: txt/cord-327169-sz4ildnd.txt
title:
  Utility and safety of bronchoscopy during SARS-CoV-2 outbreak in Italy: a retrospective, multicenter study

summary:
  The indications of bronchoscopy were: -diagnosis of SARS-CoV-2 pneumonia in patients with previously negative nasopharyngeal swab (clinical and radiological suspicion of pneumonia); -need for undelayable procedures in COVID-19 patients (e.g., massive hemoptysis, post-obstructive atelectasis). Similar findings were recently described by Torrego et al. in a Spanish cohort of COVID-19 patients who underwent bronchoscopy in ICU


id: cord-296694-2js639bk
author: Price, Laura C
title: Thrombosis and COVID-19 pneumonia: the clot thickens!
date: 2020-06-18
extension: .txt
mime: text/plain
words: 2397
sentence: 102
flesch: 34
cache: cache/cord-296694-2js639bk.txt
txt: txt/cord-296694-2js639bk.txt
summary:
  Patients: Awareness of an Increased Prevalence High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study Acute respiratory distress syndrome in critically ill patients with severe acute respiratory syndrome Analysis of deaths during the severe acute respiratory syndrome (SARS) epidemic in Singapore: challenges in determining a SARS diagnosis VTE Incidence and Risk Factors in Patients With Severe Sepsis and Septic Shock Endothelial cell infection and endotheliitis in COVID-19 Clinical and immunological features of severe and moderate coronavirus disease 2019 COVID-19 and its implications for thrombosis and anticoagulation Hypercoagulability of COVID-19 patients in Intensive Care Unit. In this edition of the European Respiratory Journal, Bompard et al. refine this further by describing a 50% cumulative incidence of pulmonary embolism (PE), diagnosed by CT-pulmonary angiogram (PA), in COVID-19 patients admitted to ICU in two hospitals of the University of Paris (ERJ ref Bompard).


id: cord-299679-6z9e5gi6
author: Rello, Jordi
title: Clinical phenotypes of SARS-CoV-2: implications for clinicians and researchers
date: 2020-05-21
extension: .txt
mime: text/plain
words: 1965
sentence: 92
flesch: 34
cache: cache/cord-299679-6z9e5gi6.txt
txt: txt/cord-299679-6z9e5gi6.txt
summary:
  The facts during the third epidemic Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Coagulopathy and antiphospholipid antibodies in patients with covid-19 Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease in patients with coagulopathy Endemic human coronaviruses in hospitalized adults with community-acquired pneumonia: results from the Louisville Pneumonia Study Towards precision medicine in sepsis: a position paper from the European Society of Clinical Microbiology and Infectious Diseases Coronavirus disease 2019 (COVID-19): a critical care perspective beyond China Utility of point-of-care lung ultrasound for initial assessment of acute respiratory distress syndrome patients in the emergency department COVID-19 pneumonia different respiratory treatment for different phenotypes? Testing for respiratory viruses in adults with severe lower respiratory infections Clinical and CT features in pediatric patients with COVID-19 infection: different points from adults Severe 2009 A/H1N1v influenza in pregnant women in Spain Coronaviruses and immunosuppressed patients.


id: cord-301318-9g547s2n
author: Zhang, Zhi-Jiang
title: Novel Coronavirus Infection in Newborn Babies Under 28 Days in China
date: 2020-04-09
extension: .txt
mime: text/plain
words: 1729
sentence: 110
flesch: 55
cache: cache/cord-301318-9g547s2n.txt
txt: txt/cord-301318-9g547s2n.txt
summary:
  Little is known about features, outcomes and intrauterine transmission potential in newborn babies aged 28 days or less. Through systematical searching, we identified 4 infections in newborn babies in China as of March 13.


id: cord-274282-hvx5m2bx
author: Liu, Yang
title: Association between ages and clinical characteristics and outcomes of coronavirus disease 2019
date: 2020-04-27
extension: .txt
mime: text/plain
words: 1543
sentence: 59
flesch: 45
cache: cache/cord-274282-hvx5m2bx.txt
txt: txt/cord-274282-hvx5m2bx.txt
summary:
  However, the ages related clinical characteristics, diseases courses and outcomes other than death in COVID-19 patients remain unclear. This is the first study to systematically evaluate the impact of age on the clinical characteristics and important outcomes for COVID-19 patients, thus helping clinicians to establish risk stratification of COVID-19 patients as early as possible.


id: cord-290080-hxte1gc1
author: Tadolini, Marina
title: On Tuberculosis and COVID-19 co-infection
date: 2020-06-25
extension: .txt
mime: text/plain
words: 757
sentence: 28
flesch: 39
cache: cache/cord-290080-hxte1gc1.txt
txt: txt/cord-290080-hxte1gc1.txt
summary:
  In their correspondence, the Authors raised two important issues, namely the possible association between tuberculosis (TB) and COVID-19 (can infection by SARS-CoV-2 reactivate TB?) and the effects of TB on early mortality in co-infected patients. Our research letter reported the first cohort of patients with diagnosis of TB (including posttreatment sequelae) and COVID-19.


id: cord-322075-e6whegrf
author: Guglielmetti, Lorenzo
title: COVID-19 in Italy - Passing through bitter waters
date: 2020-05-22
extension: .txt
mime: text/plain
words: 758
sentence: 33
flesch: 43
cache: cache/cord-322075-e6whegrf.txt
txt: txt/cord-322075-e6whegrf.txt
summary:
  [7] Other major shortfalls stem, in our opinion, from the extreme regionalization of health care, which has led to fragmentation of the decision-making process, increased inequalities, and lack of national coordination. Faced with exhausting shifts and often without adequate personal protective equipment, health care workers have been unsurprisingly affected by high rates of infection and death.


id: cord-323480-h6z3vim0
author: Li, Shao-Qiang
title: Clinical Application of Intelligent Oropharyngeal-swab Robot: Implication for COVID-19 Pandemic
date: 2020-07-16
extension: .txt
mime: text/plain
words: 1450
sentence: 60
flesch: 52
cache: cache/cord-323480-h6z3vim0.txt
txt: txt/cord-323480-h6z3vim0.txt
summary:
  OP swab samples were subjected to pathogen testing. Lastly, OP swabs were collected using MS and RS in 20 suspected COVID-19 patients, including 8 males and 12 females with the mean age of 45 ±15 years.


id: cord-277603-hpn1ovgo
author: Strapazzon, Giacomo
title: To compare the incomparable: COVID-19 pneumonia and high-altitude disease
date: 2020-06-25
extension: .txt
mime: text/plain
words: 1056
sentence: 40
flesch: 30
cache: cache/cord-277603-hpn1ovgo.txt
txt: txt/cord-277603-hpn1ovgo.txt
summary:
  In contrast to classic ARDS, lung volume and dead space in COVID-19 patients are often normal, consolidations absent and pulmonary and chest wall elastance preserved, but a severe capillary leak dominates the initial phase. [1] may rely on the initial clinical presentation of COVID-19 patients, showing profound hypoxaemia with no respiratory distress, similar to patients with acute high-altitude disease that have a chemoreceptor dysfunction.


id: cord-331497-mipg4mg7
author: McQuaid, C. Finn
title: The potential impact of COVID-19-related disruption on tuberculosis burden
date: 2020-06-08
extension: .txt
mime: text/plain
words: 1533
sentence: 48
flesch: 38
cache: cache/cord-331497-mipg4mg7.txt
txt: txt/cord-331497-mipg4mg7.txt
summary:
  We also considered three scenarios for TB health service disruption, which could be a result of a number of factors such as decreases in diagnostic activities and clinic visits, delays in diagnosis and treatment initiation, and reduced treatment support. In our worst case scenario, where COVID-19 interventions to reduce social contacts are minimal, but TB health services are badly affected, results suggest an increase in TB deaths of 23,516 (range 18,560-27,940), 149,448 (85,000-233,602) and 28,631 (19,963-40,011) in China, India and South Africa, respectively between 2020-2024, totalling 201,595 (123,523-301,553) additional TB deaths in these three countries alone.


id: cord-339934-g6ufz29l
author: Yu, Hai-qiong
title: Distinct features of SARS-CoV-2-specific IgA response in COVID-19 patients
date: 2020-05-13
extension: .txt
mime: text/plain
words: 996
sentence: 32
flesch: 32
cache: cache/cord-339934-g6ufz29l.txt
txt: txt/cord-339934-g6ufz29l.txt
summary:
  As highlighted by our study, enhanced IgA responses observed in severe COVID-19 might confer damaging effects in severe COVID-19. However, as highlighted by our study, enhanced IgA responses observed in severe COVID-19 might confer damaging effects in severe COVID-19.


id: cord-290712-flj352ql
author: Bi, Jianping
title: Does Chemotherapy Reactivate SARS-CoV-2 in Cancer Patients Recovered from Prior COVID-19 Infection?
date: 2020-09-04
extension: .txt
mime: text/plain
words: 1347
sentence: 53
flesch: 38
cache: cache/cord-290712-flj352ql.txt
txt: txt/cord-290712-flj352ql.txt
summary:
  key: cord-290712-flj352ql authors: Bi, Jianping; Ma, Hong; Zhang, Dongsheng; Huang, Jing; Yang, Dongqin; Wang, Yajie; Verma, Vivek; Zhang, Tao; Hu, Desheng; Mei, Qi; Han, Guang; Li, Jian title: Does Chemotherapy Reactivate SARS-CoV-2 in Cancer Patients Recovered from Prior COVID-19 Infection? date: 2020-09-04 journal: Eur Respir J DOI: 10.1183/13993003.02672-2020 sha: doc_id: 290712 cord_uid: flj352ql Recovered COVID-19 cancer patients remain negative for SARS-CoV-2 after delivery of chemotherapy To the Editor: Cancer patients are particularly vulnerable to coronavirus disease 2019 (COVID-19) (1) (2) (3) . To our knowledge, this is the first study reporting that recovered COVID-19 cancer patients remain negative in the short-term for SARS-CoV-2 after delivery of chemotherapy.


id: cord-307279-1yei5ifs
author: Nagra, Deepak
date: 2020-10-02
extension: .txt
mime: text/plain
words: 642
sentence: 33
flesch: 48
cache: cache/cord-307279-1yei5ifs.txt
txt: txt/cord-307279-1yei5ifs.txt
title:
  Covid-19: Opacification score is higher in the right lung and right lung involvement is a better predictor of ICU admission

summary:
  Subsequent review of between lung scores demonstrated moderate agreement (r = 0.72; κ=0.52). Opacification score is higher in the right lung and right lung involvement is a better predictor of ICU admission date: 2020-10-02 journal: Eur Respir J DOI: 10.1183/13993003.02340-2020 sha: doc_id: 307279 cord_uid: 1yei5ifs


id: cord-322580-7ohso8hl
author: Stochino, Claudia
date: 2020-06-01
extension: .txt
mime: text/plain
words: 1321
sentence: 55
flesch: 46
cache: cache/cord-322580-7ohso8hl.txt
txt: txt/cord-322580-7ohso8hl.txt
title:
  Clinical characteristics of COVID-19 and active tuberculosis co-infection in an Italian reference hospital

summary:
  This study describes clinical, radiological, and laboratory characteristics of a series of COVID-19 patients with concurrent active TB in a hospital in Sondrio province, Region Lombardy in northern Italy. key: cord-322580-7ohso8hl authors: Stochino, Claudia; Villa, Simone; Zucchi, Patrizia; Parravicini, Pierpaolo; Gori, Andrea; Raviglione, Mario Carlo title: Clinical characteristics of COVID-19 and active tuberculosis co-infection in an Italian reference hospital date: 2020-06-01 journal: Eur Respir J DOI: 10.1183/13993003.01708-2020 sha: doc_id: 322580 cord_uid: 7ohso8hl The COVID-19 infection rate was high in patient with active tuberculosis.


id: cord-330093-asba80bi
author: Leung, Janice M.
title: Smoking, ACE-2 and COVID-19: ongoing controversies
date: 2020-07-16
extension: .txt
mime: text/plain
words: 2785
sentence: 101
flesch: 40
cache: cache/cord-330093-asba80bi.txt
txt: txt/cord-330093-asba80bi.txt
summary:
  K. Farsalinos and co-workers, through analysis of the pooled prevalence of current smoking across 11 case series determined that current smoking status was significantly lower than expected gender-and age-adjusted prevalence in COVID-19 patients. [2] , of 220 hospitalised and 311 nonhospitalised patients with COVID-19 patients across six acute care hospitals and associated outpatient clinics in metropolitan Atlanta, Georgia, for instance, demonstrated that smoking was an independent risk factor for COVID-19 hospitalisation, carrying an odds ratio of 2.3 (95% CI 1.2-4.5).


id: cord-275858-46jzw94p
author: Leung, Janice M.
title: COVID-19 and COPD
date: 2020-08-13
extension: .txt
mime: text/plain
words: 3026
sentence: 83
flesch: 23
cache: cache/cord-275858-46jzw94p.txt
txt: txt/cord-275858-46jzw94p.txt
summary:
  The epidemiological data emerging from China and other early epicentres have not yet provided the necessary granularity required to determine whether these medications are harmful or beneficial in COVID-19 patients with COPD. Because of the results of the RECOVERY trial, however, it is likely that dexamethasone will become standard of care treatment for COVID-19 patients including those with COPD.


id: cord-259453-1njd0c0x
author: Nusair, Samir
title: Abnormal carbon monoxide diffusion capacity in COVID-19 patients at time of hospital discharge
date: 2020-07-23
extension: .txt
mime: text/plain
words: 2014
sentence: 87
flesch: 45
cache: cache/cord-259453-1njd0c0x.txt
txt: txt/cord-259453-1njd0c0x.txt
summary:
  Abnormal pulmonary function in COVID-19 patients at time of hospital discharge Pulmonary fibrosis secondary to COVID-19: a call to arms? Examination of the carbon monoxide diffusing capacity (DLCO) in relation to its KCO and VA components Diffusing capacity, specific diffusing capacity and interpretation of diffusion defects Immune mechanisms of pulmonary intravascular coagulopathy in COVID-19 pneumonia Pulmonary pathology of early-phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Abnormal pulmonary function in COVID-19 patients at time of hospital discharge ERS/ATS standards for single-breath carbon monoxide uptake in the lung Incorporating lung diffusing capacity for carbon monoxide in clinical decision making in chest medicine 1-year pulmonary function and health status in survivors of severe acute respiratory syndrome Follow-up study on pulmonary function and lung radiographic changes in rehabilitating severe acute respiratory syndrome patients after discharge Standardisation and application of the single-breath determination of nitric oxide uptake in the lung Endothelial cell infection and endotheliitis in COVID-19 Acute pulmonary embolism and COVID-19 pneumonia: a random association? Neuropathology of COVID-19: a spectrum of vascular and acute disseminated encephalomyelitis (ADEM)-like pathology Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19 Six month radiological and physiological outcomes in severe acute respiratory syndrome (SARS) survivors The 1-year impact of severe acute respiratory syndrome on pulmonary function, exercise capacity, and quality of life in a cohort of survivors The long-term impact of severe acute respiratory syndrome on pulmonary function, exercise capacity and health status Pulmonary sequelae in convalescent patients after severe acute respiratory syndrome: evaluation with thin-section CT Temporal changes of CT findings in 90 patients with COVID-19 pneumonia: a longitudinal study This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4 key: cord-259453-1njd0c0x authors: Nusair, Samir title: Abnormal carbon monoxide diffusion capacity in COVID-19 patients at time of hospital discharge date: 2020-07-23 journal: Eur Respir J DOI: 10.1183/13993003.01832-2020 sha: doc_id: 259453 cord_uid: 1njd0c0x On recovery from COVID-19 it is important to draw attention to the CO diffusion test and the actual meaning of the findings when considering the values of D(LCO) and D(LCO)/V(A) put together https://bit.ly/36k2O2Q


id: cord-335198-qp964238
author: Kotsimbos, T.
title: Pandemic Treatments on Trial: The bigger picture
date: 2020-08-03
extension: .txt
mime: text/plain
words: 2728
sentence: 92
flesch: 35
cache: cache/cord-335198-qp964238.txt
txt: txt/cord-335198-qp964238.txt
summary:
  Negotiating the deep chasm between frameworks is a key challenge for treating clinicians so that we don't get lost in a multitude of poorly controlled studies but leap towards a hierarchy of larger clinical trials arranged according to likelihood of success based on early but uncertain signals in smaller numbers of patients. From early, uncontrolled results that reported a clinical improvement in 68% of 53 analyzable patients (10) through to a negative RCT study result involving 236 patients which was stopped early due to reduced case numbers in China resulting in a trial with reduced power to detect any smaller clinically significant benefit with any certainty (11) to further preliminary reports of potentially positive results in larger trials sponsored by the remdisivir patent holder (12) .


id: cord-293691-ewerquin
author: Sauerhering, Lucie
date: 2020-07-02
extension: .txt
mime: text/plain
words: 3438
sentence: 146
flesch: 38
cache: cache/cord-293691-ewerquin.txt
txt: txt/cord-293691-ewerquin.txt
title:
  Cyclophilin Inhibitors Restrict Middle East Respiratory Syndrome Coronavirus Via Interferon λ In Vitro And In Mice

summary:
  Moreover, we for the first time provide evidence that CsA triggered the activation of an antiviral defense state in lung epithelial cells. These data indicate that CsA treatment mounts a distinct interferon-driven antiviral response in lung epithelial cells.


id: cord-285897-ahysay2l
author: Wu, Guangyao
date: 2020-07-02
extension: .txt
mime: text/plain
words: 3809
sentence: 149
flesch: 38
cache: cache/cord-285897-ahysay2l.txt
txt: txt/cord-285897-ahysay2l.txt
title:
  Development of a Clinical Decision Support System for Severity Risk Prediction and Triage of COVID-19 Patients at Hospital Admission: an International Multicenter Study

summary:
  General quarantine and symptomatic treatment at home or mobile hospital can be used for most non-severe patients, while a higher level of care and fast track to the intensive care unit (ICU) is needed for severe patients. There were significant difference for the proportion of severe patients among low, medium, and high-risk groups in the five test datasets (Figure 5 ).


id: cord-296440-18vpg419
author: Beurnier, Antoine
date: 2020-07-30
extension: .txt
mime: text/plain
words: 3554
sentence: 159
flesch: 44
cache: cache/cord-296440-18vpg419.txt
txt: txt/cord-296440-18vpg419.txt
title:
  Characteristics and outcomes of asthmatic patients with COVID-19 pneumonia who require hospitalisation

summary:
  Indeed, sputum analysis showed that ACE2 expression levels are significantly lower in asthma patients taking ICS than in those not taking ICS, especially when high doses are administrated [19] . However, more concern has been recently raised about thrombosis and pulmonary embolism in COVID-19 patients [28] , underscoring that this complication may be more prevalent in this patient population.


id: cord-337889-90q4py0j
author: Guan, Wei-jie
title: Comorbidity and its impact on 1590 patients with Covid-19 in China: A Nationwide Analysis
date: 2020-03-26
extension: .txt
mime: text/plain
words: 4722
sentence: 182
flesch: 36
cache: cache/cord-337889-90q4py0j.txt
txt: txt/cord-337889-90q4py0j.txt
summary:
  Tujia Autonomous County People's Hospital, The first people's Hospital of Wanzhou District, Chongqing, Yongchuan Hospital Affiliated to Chongqing Medical University, Anguo hospital, The Third Hospital of Peking University, peking university shenzhen hospital , BOLUO people's Hospital, Changde Lixian people's Hospital, Changde Second People's Hospital, Chenzhou Central Hospital, Chengjiang people's Hospital, Dalian Central Hospital, Danzhou people's Hospital, Dengzhou Central Hospital Hangzhou first people's Hospital, Hangzhou Lin'an District People's Hospital, Nanpi County Hospital of traditional Chinese medicine of Hebei Province, Henan people's Hospital, Hefeng County Central Hospital, Hohhot First Hospital, Huludao Central Hospital, The First Affiliated Hospital of Hunan Medical College, Shenzhen Union Hospital of Huazhong University of science and technology, Huaibei people's Hospital, Huangshi Second Hospital, Huangchuan people's Hospital Jiangyou infectious diseases hospital, Jieyang people's Hospital, Jinhua Central Hospital, Jinzhong Pingyao people's Hospital, Jingjiang people's Hospital, The Second Affiliated Hospital of Kunming Medical University, Laifeng County Central Hospital, Yueqing people's Hospital, Lijiang people's Hospital, Lixin people's Hospital, The Fourth People's Hospital of Lianyungang, Linqu County People's Hospital Xuanwu Hospital of Capital Medical University, Sichuan Mianyang 404 hospital, Sixian Hospital of traditional Chinese Medicine, Suihua First Hospital, Suiping County People's Hospital, Tianjin Fourth Central Hospital, Tianjin Haihe hospital, Tiantai County People's Hospital, Tongchuan Mining Bureau Central Hospital, Tongren people's Hospital, Weihai Central Hospital, The First Affiliated Hospital of Wenzhou Medical University, Wuzhou Third People's Hospital, Armed police Hubei provincial general team hospital, Xixian people's Hospital, Longshan County People's The First Affiliated Hospital of Xinjiang Medical University, Xinmi Hospital of traditional Chinese Medicine, Xinxiang County People's Hospital, Xinye people's Changsha eighth hospital, Changsha first people's Hospital, 921st Hospital of the joint service support force of the Chinese people's Liberation Army, Central theater General Hospital of the Chinese people's Liberation Army, The First Affiliated Hospital of China Medical University, The Third Affiliated Hospital of Zhongshan University, Zhongshan Second People's Hospital, Chongqing Chengkou people's Hospital, Chongqing Hechuan District People's Hospital, Chongqing Red Cross Hospital, Zhoushan women's and children's Hospital, Zhoukou infectious diseases hospital, Zhuzhou first people's Hospital, Zhumadian Central Hospital, Anlong people's Hospital, Anxi County Hospital, Anyang Fifth People's Hospital, Anyang People's Hospital, Anyuan people's Hospital, Badong County Ethnic hospital, Wuyuan County People's Hospital of Bayannur City, Baise people's Hospital, The First Affiliated Hospital of Bengbu Medical College, Baoding first Central Hospital, Changping District Hospital of Beijing Municipality, Changping District Hospital of traditional Chinese and Western medicine of Beijing Chizhou people's Hospital, Chongxin County People's Hospital, Chongyi people's Hospital, Affiliated Hospital of North Sichuan Medical College, Dazhou Central Hospital, Dali first people's Hospital, The Second Affiliated Hospital of Dalian Medical University, The First Affiliated Hospital of Dalian Medical University, Danyang people's Hospital, Daocheng people's Hospital, Deqing people's Hospital, Dezhou Second People's Hospital, Dezhou people's Hospital, Dezhou Qingyun people's Hospital Fuzhou Fifth People's Hospital, Fuzhou Dongxiang District People's Hospital, Fuyang District First People's Hospital, Ganzhou Longnan County People's Hospital, Gaolan County People's Hospital, Gongcheng Yao Autonomous County People's Hospital, Gushi people's Hospital, Guang'an people's Hospital, Guangdong Hospital of traditional Chinese Medicine, Guangzhou Eighth People's Hospital, Guangzhou 12th Novel Coronavirus (2019-nCoV) situation reports Clinical features of patients with 2019 novel coronavirus in Wuhan Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case studies A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster High-resolution CT features of 17 cases of Corona Virus Disease 2019 in Sichuan province, China The clinical dynamics of 18 cases of COVID-19 outside of Wuhan, China Epidemiological characteristics of 2019-ncoV infections in Shaanxi Clinical Characteristics of Coronavirus Disease 2019 in China Clinical findings in 111 cases of influenza A (H7N9) virus infection Association of age and comorbidity on 2009 influenza A pandemic H1N1-related intensive care unit stay in Massachusetts The burden of influenza complications in different high-risk groups Differences in the epidemiological characteristics and clinical outcomes of pandemic (H1N1) 2009 influenza, compared with seasonal influenza Risk factors associated with severe outcomes in adult hospitalized patients according to influenza type and subtype Effect of vaccination, comorbidities and age on mortality and severe disease associated with influenza during the season 2016-2017 in a Spanish tertiary hospital Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area Prevalence of comorbidities in cases of Middle East respiratory syndrome coronavirus: a retrospective study Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV) Risk Factors for Fatal Middle East Respiratory Syndrome Coronavirus Infections in Saudi Arabia: Analysis of the WHO Line List Diabetes Mellitus, Hypertension, and Death among 32 Patients with MERS-CoV Infection, Saudi Arabia Impact of Comorbidity on Fatality Rate of Patients with Middle East Respiratory Syndrome A Comparative Study of Clinical Presentation and Risk Factors for Adverse Outcome in Patients Hospitalised with Acute Respiratory Disease Due to MERS Coronavirus or Other Causes Chongqing Yunyang County People's Hospital, Ankang Central Hospital, Chenzhou Second People's Hospital, Datong Fourth People's Hospital, Dengzhou people's Hospital, Fengjie people's Hospital, Foshan first people's Hospital, Fuyang Second People's Hospital, Gongyi people's Hospital, Guangshan people's Hospital, Guoyao Dongfeng General Hospital, Hainan people's Hospital, The Second Affiliated Hospital of Hainan Medical College, The first people's Hospital of Xiaoshan District, Hangzhou, Huaihua first people's Hospital, Jiashan first people's Hospital, Lu'an people's Hospital, Affiliated Hospital of Qingdao University, Qingyuan people's Hospital, Quanzhou County People's Hospital, Rizhao people's Hospital, Shaodong people's Hospital, Shiyan Xiyuan Hospital, Tongling people's Hospital, Wenzhou People's Hospital, Wenzhou Central Hospital, The Second Affiliated Hospital of Wenzhou Medical University, Wuxi Fifth People's Hospital Zhijiang people's Hospital, People's Hospital of Dianjiang County, Chongqing, Chongqing Jiulongpo first people's Hospital, Chongqing Shizhu


id: cord-012010-5h2ox3hu
author: Bos, Lieuwe D.J.
date: 2020-08-03
extension: .txt
mime: text/plain
words: 2154
sentence: 81
flesch: 31
cache: cache/cord-012010-5h2ox3hu.txt
txt: txt/cord-012010-5h2ox3hu.txt
title:
  Response to “COVID-19 conundrum: Clinical phenotyping based on pathophysiology as a promising approach to guide therapy in a novel illness” and “Strengthening the foundation of the house of CARDS by phenotyping on the fly” and “COVID-19 phenotypes: leading or misleading?”

summary:
  Further, a recent report from Haudebourg et al. demonstrated no correlation between duration of symptoms and respiratory compliance in COVID-19 patients ( Figure 1a ) We merely disagree with the correspondent's conclusions regarding the prevalence of these theoretical patients based on data from 16 patients [20] , as well as their subsequent recommendations to deviate from safe ventilatory practice for COVID-19 patients based on this limited data.


id: cord-335465-sckfkciz
author: Gupta, Rishi K.
date: 2020-09-25
extension: .txt
mime: text/plain
words: 5056
sentence: 190
flesch: 27
cache: cache/cord-335465-sckfkciz.txt
txt: txt/cord-335465-sckfkciz.txt
title:
  Systematic evaluation and external validation of 22 prognostic models among hospitalised adults with COVID-19: An observational cohort study

summary:
  The most discriminating univariable predictor is admission oxygen saturation (SpO2) on room air for deterioration models and patient age for mortality models. Importantly, prognostic models may have additional value in patient stratification for emerging drug therapies [6, 7] .


id: cord-347046-u764muk6
author: Morice, Alyn H.
title: Correlation and Causality: a Covid Conundrum
date: 2020-08-28
extension: .txt
mime: text/plain
words: 578
sentence: 24
flesch: 55
cache: cache/cord-347046-u764muk6.txt
txt: txt/cord-347046-u764muk6.txt
summary:
  If the mortality curves have a similar shape despite large differences in social measures adopted then this must infer that such measures can only have had a minor effect on the epidemiology of this phase of the pandemic. They assume the current fall in the rate of COVID-19 related mortality is a consequence of lockdown; but is it?


id: cord-352502-vdm55zvq
author: Salton, Francesco
title: Response to: Factors limiting the utility of bronchoalveolar lavage in the diagnosis of COVID-19
date: 2020-09-17
extension: .txt
mime: text/plain
words: 646
sentence: 22
flesch: 39
cache: cache/cord-352502-vdm55zvq.txt
txt: txt/cord-352502-vdm55zvq.txt
summary:
  Factors limiting the utility of bronchoalveolar lavage in the diagnosis of COVID-19 date: 2020-09-17 journal: Eur Respir J DOI: 10.1183/13993003.03383-2020 sha: doc_id: 352502 cord_uid: vdm55zvq We aimed at evaluating not the diagnostic yield of BAL in COVID-19, but the agreement between negative upper respiratory tract swabs and BAL to exclude COVID-19, stressing that BAL is likely negative if swabs and chest CT are concordantly negative. These findings support our main observation that BAL is likely to be negative if one or more upper respiratory tract specimens and thoracic imaging are concordantly negative, therefore it should be only reserved for those cases in which a high clinical and radiological suspicion for COVID-19 stands despite negative upper respiratory tract swabs.


id: cord-349440-jxigsdzh
author: Gattinoni, Luciano
title: COVID-19 phenotypes: leading or misleading?
date: 2020-07-02
extension: .txt
mime: text/plain
words: 565
sentence: 19
flesch: 39
cache: cache/cord-349440-jxigsdzh.txt
txt: txt/cord-349440-jxigsdzh.txt
summary:
  The fact that COVID-19 patients with similar oxygenation efficiency may have markedly different compliance (and VILI risk) is apparent to any clinician who has ever looked after a number of these patients. The perils of premature phenotyping in COVID: a call for caution COVID-19 pneumonia: different respiratory treatments for different phenotypes? Management of COVID-19 Respiratory Distress


id: cord-351349-ypaevb8b
author: van Koningsbruggen-Rietschel, Silke
title: SARS-CoV2 disrupts clinical research - the role of a rare disease-specific trial network
date: 2020-08-07
extension: .txt
mime: text/plain
words: 894
sentence: 38
flesch: 43
cache: cache/cord-351349-ypaevb8b.txt
txt: txt/cord-351349-ypaevb8b.txt
summary:
  We believe that disease specific CTNs are an effective way for rare disease clinical trial sites to learn from each other and overcome obstacles such as the current pandemic, while working towards the goals of effective treatments for rare diseases. key: cord-351349-ypaevb8b authors: van Koningsbruggen-Rietschel, Silke; Dunlevy, Fiona; Bulteel, Veerle; Downey, Damian; Dupont, Lieven title: SARS-CoV2 disrupts clinical research - the role of a rare disease-specific trial network date: 2020-08-07 journal: Eur Respir J DOI: 10.1183/13993003.02114-2020 sha: doc_id: 351349 cord_uid: ypaevb8b Rare disease patients may suffer delayed access to new drugs as SARS-CoV-2 is disrupting clinical trials.


id: cord-338351-y1t9emu1
author: Ora, Josuel
title: Does bronchoscopy help the diagnosis in Covid-19 infection?
date: 2020-06-11
extension: .txt
mime: text/plain
words: 973
sentence: 29
flesch: 30
cache: cache/cord-338351-y1t9emu1.txt
txt: txt/cord-338351-y1t9emu1.txt
summary:
  There are two main problems in negative swab patients with CT scans and clinical picture suggestive for COVID-19: firstly, according to the sensitivity of the swabs, misdiagnosing a SARS-CoV-2 positive patient may be a great risk for public health, secondly, an alternative diagnosis may be required for patients' appropriate treatment. However the role of bronchoscopy in ruling out suspected COVID-19 patients is under debate.


id: cord-351407-7vx9lzi0
author: Mehta, Puja
title: JAK inhibitors in COVID-19: need for vigilance regarding increased inherent thrombotic risk
date: 2020-07-06
extension: .txt
mime: text/plain
words: 1252
sentence: 45
flesch: 24
cache: cache/cord-351407-7vx9lzi0.txt
txt: txt/cord-351407-7vx9lzi0.txt
summary:
  We recommend risk mitigation strategies including consideration of exclusion of patients with high thrombotic risk, treatment with standard or intermediate-dose low molecular weight heparin prophlyaxis 7 during hospitalisation and consideration of increased thrombotic risk associated with JAKi, given the hypercoagulability of COVID-19. Although it was initially thought that insidious venous thromboembolic events (VTE) were mainly confined to ventilated patients [3], we now understand thrombotic risk to be a wider problem in COVID-19.


id: cord-354290-o5i4a7nl
author: Li, Jie
title: Author's Reply on High-Flow Nasal Cannula for COVID-19 Patients: Low Risk of Bio-Aerosol Dispersion
date: 2020-08-28
extension: .txt
mime: text/plain
words: 1233
sentence: 46
flesch: 48
cache: cache/cord-354290-o5i4a7nl.txt
txt: txt/cord-354290-o5i4a7nl.txt
summary:
  The presented in vitro data [2] from a light detection of smoke dispersion distance and velocity model suggesting that high-flow nasal cannula (HFNC) generates larger dispersion distance than nonbreather mask and venturi mask is in contrast to reports from Hui et al., using a similar model [3]. The presented in vitro data 2 from a light detection of smoke dispersion distance and velocity model suggesting that high-flow nasal cannula (HFNC) generates larger dispersion distance than nonbreather mask and venturi mask is in contrast to reports from Hui et al, using a similar model 3 .


id: cord-355753-muefay2n
author: Garner, Justin L.
title: Challenges of evaluating lung function as part of cancer care during the COVID-19 pandemic
date: 2020-07-02
extension: .txt
mime: text/plain
words: 1264
sentence: 38
flesch: 22
cache: cache/cord-355753-muefay2n.txt
txt: txt/cord-355753-muefay2n.txt
summary:
  Total lung capacity and residual volumes, estimated on CT scans respectively made in maximum inspiration and expiration have also been shown to correlate well with plethysmographic-derived measurements (17) . The Lancet Oncology Guidelines on the radical management of patients with lung cancer Pulmonary Function Laboratories: Advice Regarding COVID-19 Peak-flow or portable spirometry as a replacement for Spirometry in the diagnosis of COPD and Asthma The Use of Home Spirometry in Pediatric Cystic Fibrosis Patients: Results of a Feasibility Study Development of quantitative computed tomography lung protocols Relationships between airflow obstruction and quantitative CT measurements of emphysema, air trapping, and airways in subjects with and without chronic obstructive pulmonary disease Prediction of postoperative lung function in patients with lung cancer: comparison of quantitative CT with perfusion scintigraphy A randomized study using functional respiratory imaging to characterize bronchodilator effects of glycopyrrolate/formoterol fumarate delivered by a metered dose inhaler using cosuspension delivery technology in patients with COPD Quantitative Evaluation of Lobar Pulmonary Function of Emphysema Patients with Endobronchial Coils.


id: cord-349958-126yb5se
author: Raskin, Jo
title: CANCER IN THE TIME OF COVID: Expert opinion on how to adapt current practice
date: 2020-04-16
extension: .txt
mime: text/plain
words: 1591
sentence: 86
flesch: 45
cache: cache/cord-349958-126yb5se.txt
txt: txt/cord-349958-126yb5se.txt
summary:
  349958 cord_uid: 126yb5se The susceptibility of cancer patients to adverse outcome of viral infections is well known from past experiences, e.g. Influenza increasing the risk of hospital admission with respiratory distress four times, and the risk of death ten times, compared to patients without cancer [1]. To the editor: The susceptibility of cancer patients to adverse outcome of viral infections is well known from past experiences, e.g. Influenza increasing the risk of hospital admission with respiratory distress four times, and the risk of death ten times, compared to patients without cancer [1] .


id: cord-344641-rog2h4g7
author: Franco, Cosimo
date: 2020-08-03
extension: .txt
mime: text/plain
words: 3704
sentence: 131
flesch: 43
cache: cache/cord-344641-rog2h4g7.txt
txt: txt/cord-344641-rog2h4g7.txt
title:
  Feasibility and clinical impact of out-of-ICU non-invasive respiratory support in patients with COVID-19 related pneumonia

summary:
  The overall rate of workers infected, in personnel not specifically involved in the care of COVID-19 patients, in the nine hospitals was 3.8±1.9%. Nevertheless, WHO advocate using CPAP or NIV for the management of respiratory failure in COVID-19 patients, provided that appropriate PPE is worn by the personnel (9) .


id: cord-350166-loxe11d6
author: Garmendia, Onintza
date: 2020-04-20
extension: .txt
mime: text/plain
words: 4275
sentence: 127
flesch: 28
cache: cache/cord-350166-loxe11d6.txt
txt: txt/cord-350166-loxe11d6.txt
title:
  Low-cost, easy-to-build non-invasive pressure support ventilator for under-resourced regions: open source hardware description, performance and feasibility testing

summary:
  Although tidal volume was not a direct outcome variable controlled by pressure support ventilators, it is interesting to note that the prototype ventilator resulted in tidal volumes that were similar to the ones generated by the commercial device ( Figure 5.B) , adding further support to the suitability of the prototype ventilator for generating inspiratory pressure waveforms and adequate tidal volumes in a wide spectrum of simulated patients ( Table 1 ). In this context, alternative solutions that are based on in-house manufacturing of pressure support devices (7, 8) could reduce the serious shortage of ventilators in LMICs.


