id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
cord-335198-qp964238	Kotsimbos, T.	Pandemic Treatments on Trial: The bigger picture	2020-08-03		.txt	text/plain	2728	92	35	Negotiating the deep chasm between frameworks is a key challenge for treating clinicians so that we don't get lost in a multitude of poorly controlled studies but leap towards a hierarchy of larger clinical trials arranged according to likelihood of success based on early but uncertain signals in smaller numbers of patients. From early, uncontrolled results that reported a clinical improvement in 68% of 53 analyzable patients (10) through to a negative RCT study result involving 236 patients which was stopped early due to reduced case numbers in China resulting in a trial with reduced power to detect any smaller clinically significant benefit with any certainty (11) to further preliminary reports of potentially positive results in larger trials sponsored by the remdisivir patent holder (12) .	cache/cord-335198-qp964238.txt	txt/cord-335198-qp964238.txt
