id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
eurjchem-1059	Samala, Ganesh; Madhuri, Chunduri; Sridevi, Jonnalagadda Padma; Nallangi, Radhika; Perumal, Yogeeswari; Dharmarajan, Sriram	Synthesis and antitubercular evaluation of 2-iminothiazolidine-4-ones	2014	7	.pdf	application/pdf	7314	362	75	Samala et al. / European Journal of Chemistry 5 (3) (2014) 550‐556 555 Table 1. Biological activities of synthesized compounds. Compound R2 Yield (%) M.p. (°C) C log P MTB MIC (µM) MTB MIC (µM) (in presence of verapamil) Cytotoxicity at 100 µM (RAW 264.7 cells) % Inhibition 4a 2‐Hydroxyphenyl 90 208‐209 4.64 65.24 ND * ND 4b 4‐Hydroxyphenyl 88 221‐222 4.64 16.31 ND 22.60 4c 4‐Methoxyphenyl 79 189‐190 5.22 4.12 2.06 17.82 4d 4‐Benzyloxyphenyl 93 218‐220 6.99 6.88 6.88 19.04 4e 4‐Methylphenyl 81 205‐207 5.80 138.12 ND ND 4f 4‐(Dimethylamino)phenyl 84 234‐235 5.47 110.13 ND ND 4g 3,4,5‐Trimethoxyphenyl 89 208‐209 4.61 7.11 1.77 21.64 4h 2‐Fluorophenyl 80 201‐203 5.45 4.25 1.06 22.80 4i 4‐Chlorophenyl 79 209‐211 6.02 130.54 ND ND 4j 3‐Nitrophenyl 76 180‐181 5.05 63.45 ND ND 4k 5‐Nitrofuran‐2‐yl 92 231‐232 4.22 4.07 4.07 26.72 4l 5‐Nitrothiophen‐2‐yl 72 241‐243 4.78 12.53 ND 24.62 5a 2‐Hydroxyphenyl 88 218‐220 1.99 117.3 ND 12.86 5b 4‐Hydroxyphenyl 79 213‐214 1.99 39.1 ND 18.98 5c 4‐Methoxyphenyl 84 204‐205 2.58 3.78 1.89 14.56 5d 4‐Benzyloxyphenyl 93 241‐243 4.35 6.40 1.60 16.40 5e 4‐Methylphenyl 89 260‐262 3.16 63.12 ND ND 5f 4‐(Dimethylamino)phenyl 76 290‐291 2.82 118.48 ND ND 5g 3,4,5‐Trimethoxyphenyl 88 207‐208 1.96 3.31 0.82 12.40 5h 2‐Fluorophenyl 78 236‐238 2.80 3.90 3.90 16.86 5i 4‐Chlorphenyl 81 222‐223 3.37 59.95 ND ND 5j 3‐Nitrophenyl 88 196‐198 2.41 14.63 ND 20.62 5k 5‐Nitrofuran‐2‐yl 69 232‐233 1.58 7.49 3.74 24.62 5l 5‐Nitrothiophen‐2‐yl 76 241‐242 2.14 7.21 3.60 18.72 6a 2‐Hydroxyphenyl 83 218‐220 3.54 44.85 ND 28.72 6b 4‐Hydroxyphenyl 81 227‐228 3.54 22.42 ND 16.32 6c 4‐Methoxyphenyl 84 232‐233 4.13 17.22 ND 22.30 6d 4‐Benzyloxyphenyl 91 208‐210 5.89 15.26 ND 20.63 6e 4‐Methylphenyl 88 249‐250 4.71 54.18 ND ND 6f 4‐(Dimethylamino)phenyl 72 281‐283 4.37 132.62 ND ND 6g 3,4,5‐Trimethoxyphenyl 83 210‐213 3.51 7.40 3.7 14.80 6h 2‐Fluorophenyl 79 223‐225 4.35 4.26 2.13 20.62 6i 4‐Chlorphenyl 72 243‐244 4.92 85.30 ND ND 6j 3‐Nitrophenyl 84 204‐206 3.95 66.31 ND ND 6k 5‐Nitrofuran‐2‐yl 70 254‐255 3.13 6.81 1.70 18.92 6l 5‐Nitrothiophen‐2‐yl 72 241‐243 3.69 6.52 1.63 23.26 Isoniazid 0.72 0.72 ND Rifampicin 0.24 0.24 ND Ethambutol 7.64 3.82 ND Pyrazinamide 50.77 ND ND Ciprofloxacin 4.71 4.71 ND * ND indicates not determined. MS (EI, m/z (%)): 238 [M+H]+. 2‐Chloro‐N‐(5‐nitrothiazol‐2‐yl)acetamide (2b): 5‐Nitro thiazol‐2‐amine (3.0 g, 20.80 mmol) and chloroacetyl chloride (1.64 mL, 20.80 mmol) were taken in benzene (25 mL) and the reaction mixture was refluxed for 6 h.	cache/eurjchem-1059.pdf	txt/eurjchem-1059.txt