id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
eurjchem-1072	Abdelmohsen, Shawkat Ahmed	A convenient synthesis and preparation of the derivatives of ethyl-6-(8-hydroxyquinolin-5-yl)-3-methylpyridazine-4-carboxylate as antimicrobial agents	2014	9	.pdf	application/pdf	6395	372	70	General procedure for the synthesis of compounds (10a,b) and (14a,b) A mixture of compound 9 or 13 (5 mmol), ethyl iodide and/or benzyl bromide (5 mmol) in ethanol (30 mL) was refluxed in the presence of anhydrous sodium acetate (5 mmol) for 4 h. 2.2.12. General procedure for the synthesis of compounds (19a‐c) A mixture of compound 8 (10 mmol) and the appropriate aromatic aldehyde (10 mmol) was stirred under reflux in ethanol (30 mL) in the presence of a few drops of piperidine for 5 h. The reaction mixture was allowed to cool to room temperature, poured into water, whereby a solid formed that was filtered off and crystallized from an appropriate solvent (Scheme 4). 6‐(8‐Hydroxyquinolin‐5‐yl)‐N'‐[phenylmethylidene]‐3‐methyl pyridazine‐4‐carbohydrazide (19a): Color: Pale white from acetic acid.	cache/eurjchem-1072.pdf	txt/eurjchem-1072.txt