id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
eurjchem-1096	Nguyen, Van Hung; Pham, Van Cuong; Mai, Huong Doan Thi; Le, Thanh Nguyen; Nguyen, Thi Minh Hang; Vu, Van Nam; Tran, Huu Giap; Do, Thi Thao; Dehaen, Wim; Chau, Van Minh	Synthesis and biological evaluation of shikimic acid derivatives	2014	6	.pdf	application/pdf	6098	271	74	Compounds IC50 (μg/mL) Compounds IC50 (μg/mL) KB MCF‐7 LU‐1 KB MCF‐7 LU‐1 4a 72.0 38.2 40.1 7c 98.7 97.6 99.8 4b 9.6 8.0 8.8 7d >100 >100 >100 4c 39.7 42.9 45.0 7e 84.6 72.7 74.1 4d >100 >100 >100 7f 15.7 15.0 15.3 4e 79.7 62.5 82.9 Ellipticine 1.1 0.9 0.9 7a 84.9 80.0 79.7 Oseltamivir phosphate >100 >100 >100 7b 27.6 24.1 25.8 1H NMR (500 MHz, CDCl3, δ, ppm): 0.84 (d, J = 6.5 Hz, 3H, CH3‐3″), 0.88 (d, J = 6.5 Hz, 3H, CH3‐4″), 1.27 (t, J = 7.0 Hz, 3H, CH3‐2′), 1.77 (m, 1H, H‐2″), 2.01 (s, 3H, Ac), 2.12 (m, 1H, Ha‐6), 2.75 (dd, J = 5.0, 17.5 Hz, 1H, Hb‐6), 2.99 (m, 1H, H‐5), 3.10 (dd, J = 8.0, 15.0 Hz, 1H, Ha‐1″), 3.36 (dd, J = 8.0, 15.0 Hz, 1H, Hb‐1″), 3.74 (q, J = 9.0 Hz, 1H, H‐4), 4.06 (m, 1H, H‐3), 4.17 (q, J = 6.5 Hz, 2H, CH2‐1′), 6.03 (br. s, 1H, NH), 6.79 (br. s, 1H, H‐2). As oseltamivir had no cytotoxicity against different cell lines such as MCF‐7, LU‐1, KB, MDCK, MRC‐5, VERO, MK and 293, the modification of alkyl groups at C‐3 of the oseltamivir ring framework could significantly increase the cytotoxicity for this class of compounds.	cache/eurjchem-1096.pdf	txt/eurjchem-1096.txt