id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
eurjchem-1324	Abdelwahab, Nada Sayed; Abdelrahman, Maha Mohammed; Salama, Fathy Mahmoud; Ahmed, Amal Badawy	Determination of dimenhydrinate and cinnarizine in combined dosage form in presence of cinnarizine impurity	2015	7	.pdf	application/pdf	4581	195	49	Ratio of CIN:DMH % Impurity Concentration taken (µg/mL) % Recovery CIN DMH IMP CIN DMH IMP Method A 3:1 10 27 10 3 100.97 101.25 98.64 1:2 30 14 40 6 99.84 101.51 100.04 1:1 40 9 30 6 101.70 98.06 99.69 1:1 50 10 20 10 101.35 101.59 101.30 1:1 70 6 20 14 101.12 101.41 101.50 1:2 80 4 10 16 99.24 98.00 98.26 Mean±SD 100.14±1.177 99.60±1.404 100.12±1.237 Method B 3:1 10 27 10 3 99.36 101.36 100.26 1:2 30 14 40 6 101.21 99.54 101.11 1:1 40 9 30 6 99.83 99.31 98.66 1:1 50 10 20 10 99.99 99.45 99.26 1:1 70 6 20 14 100.78 101.59 99.80 1:2 80 4 10 16 101.78 99.31 100.32 Mean±SD 99.90±0.863 100.09±1.076 100.49±0.919 Method C 3:1 10 27 10 3 100.39 98.13 100.38 1:2 30 14 40 6 99.63 98.26 98.68 1:1 40 9 30 6 101.06 99.51 99.39 1:1 50 10 20 10 101.87 99.23 101.28 1:1 70 6 20 14 99.34 100.83 101.68 1:2 80 4 10 16 98.45 101.66 99.43 Mean ± SD 99.90±1.331 100.30±1.764 100.70±0.953 For determination of CIN, the recorded spectra of CIN were divided by the standard spectrum of 20 µg/mL DMH to obtain the first ratio spectra which were then mean centered. The work in this manuscript concerned with the development and validation of three accurate, selective and precise spectro‐ photometric methods for resolving the overlapped spectra of DMH, CIN and IMP (Figure 2) with minimum sample prepa‐ ration and data manipulation. 4.1. Method development and validation There are many factors that affect selectivity and sensitivity of the developed methods such as: the used solvent, the divisor concentration and the chosen wavelength.	cache/eurjchem-1324.pdf	txt/eurjchem-1324.txt