id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
eurjchem-1434	Abou-El Alamin, Maha Mahmoud	Ultra-performance liquid chromatography coupled to electrospray ionization-tandem mass spectrometric method for simultaneous determination of acemetacin in presence of its metabolite indomethacin and degradation products	2016	4	.pdf	application/pdf	2614	122	45	ARTICLE INFORMATION ABSTRACT DOI: 10.5155/eurjchem.7.2.213‐216.1434 Received: 02 April 2016 Received in revised form: 23 April 2016 Accepted: 29 April 2016 Published online: 30 June 2016 Printed: 30 June 2016 Selective and sensitive ultra‐performance liquid chromatography‐tandem mass spectrometric technique (UPLC‐MS/MS) was investigated for simultaneous determination of acemetacin (ACM) in presence of its metabolite (indomethacin) and degradation products in 3 min run time. The column employed was a Hypersil gold 50 mm × 2.1 mm (1.9 μm) with an isocratic mobile phase consisted of 0.1% formic acid aqueous solution and acetonitrile (10:90, v:v) with flow rate 250 µL/min. Detection of the cited drug was carried out using multiple reaction monitoring (MRM) mode on a triple quadrupole mass spectrometer coupled with electrospray ionization (ESI) m/z 416.44 → 139.24 for ACM and m/z 256.31 → 167.00 for diphenhydramine internal standard.	cache/eurjchem-1434.pdf	txt/eurjchem-1434.txt