id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
eurjchem-201	Saeed, Aamer	Synthesis of 8-hydroxy-6-methoxy-3-pentyl-1H-isochromen-1-one from Tessmannia densiflora	2011	3	.pdf	application/pdf	1672	109	61	Isocoumarins are isomeric to coumarins with an inverted lactone ring. The construction of isocoumarin 3 from the anhydride 2 may be visualized by the loss of a benzylic proton to base to afford the resonance stabilized anionic species (2a and 2b), which attacks the hexanoyl chloride to give the 4‐ hexanoyl‐6,8‐dimethoxyisochroman‐1,3‐dione intermediate I. Loss of proton to the base affords the species II a, b, which upon intramolecular O‐acylation furnishes the tricyclic intermediate III, which under basic influence undergoes ring opening to afford IV.	cache/eurjchem-201.pdf	txt/eurjchem-201.txt