id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
eurjchem-518	El-Ziaty, Ahmed; Abdalh, Abdelaal; Hamed, Ashraf; Shiba, Sayed; Abdullha, Abdelhafed	Synthesis of novel 2-propenoyl amides, esters, heterocyclic compounds and their screening as antifungal and antibacterial agents	2012	6	.pdf	application/pdf	3785	251	78	El‐Ziaty et al. / European Journal of Chemistry 3 (1) (2012) 65‐70 67 3 Ar H Cl O CN Ar H X O NC Ar/ 4, X = O; Ar/ = C6H5 5, X = S; Ar/ = C6H4(4-Cl) 6, X = NH; Ar/ = C6H4(P-OCH3) 7, X = NH; Ar/ = C6H4(P-CH3) 8, X = NH;.Ar/ = C6H4 (P-Cl) 9, X = NH; Ar/ = 3-Pyridyl 4-9 Ph CO NH NH 2 Ar H N H O CN 10 PO Cl 3 NN O Ph NC 11 Ar H NH 2CSNHCH 3 2-aminpryidine N N OH NC Ar CH3 S 12 Ar H N H O CN O 13 Ar H CN O N H N 14 + N N Ar NC HO 15 Ar = C6H3Cl2(2,4) N H Ph H N Ph O Scheme 2 4‐(2,4‐dichlorophenyl)‐2‐hydroxy‐4H‐pyrimido[1,2‐a] pyrimidine‐3‐carbonitrile (15): Yellow. 65‐70 69 H Ar C N NH O S HN H3C -H/+H N NH CN Ar H3C S O N NH CN O S H3C Ar 12 CN H Ar COCl H2N N H S CH3 T.E.A -HCl 3 -H2 N N CN OH S H3C Ar Scheme 4 Scheme 5 3. Results and discussion In continuation of our efforts to study the reactivity of 2‐ propenoyl chlorides towards some nitrogen and oxygen nucleophilic reagents [20‐23], we reported herein, the synthesis of a new compound, (E)2‐cyano‐3‐(2,4‐dichloro phenyl)acryloyl chloride 3 via the common route condensation of 2,4‐dichlorobenzaldehyde with ethyl cyanoacetate in the presence of piperidine, to give the corresponding (E)‐ethyl 2‐ cyano‐3‐(2,4‐dichlorophenyl) acrylate, 1,	cache/eurjchem-518.pdf	txt/eurjchem-518.txt